diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/4Y3Fr6urRB4.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/4Y3Fr6urRB4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ee3ed42b1c6ff82ca5428f42fbfe69d45739cc25
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/4Y3Fr6urRB4.srt
@@ -0,0 +1,2443 @@
+1
+00:00:20,650 --> 00:00:22,790
+بسم الله والحمد لله والصلاة والسلام عليك بسم الله
+
+2
+00:00:22,790 --> 00:00:28,530
+كنا بدنا نتكلم الأسبوع الماضي عن الـ network
+
+3
+00:00:28,530 --> 00:00:32,170
+programming واخدنا بعض المصطلحات أو بعض المفاهيم 
+
+4
+00:00:32,170 --> 00:00:37,070
+المهمة للشبكات وكان أهمها أن شبكة الـ computer هي
+
+5
+00:00:37,070 --> 00:00:41,370
+عبارة عن interconnected devices مجموعة من الأجهزة
+
+6
+00:00:41,370 --> 00:00:45,910
+المتصلة تهدف إلى مشاركة الـ data sources أو الـ
+
+7
+00:00:45,910 --> 00:00:51,070
+resources اللي متوفرة عليها وقلنا الشبكات بتاخد
+
+8
+00:00:51,070 --> 00:00:53,710
+physical connection فيها physical connection وفيها
+
+9
+00:00:53,710 --> 00:00:57,410
+logical architecture في الـ physical connection قلت
+
+10
+00:00:57,410 --> 00:01:00,030
+أنا في عندها أو سميناها بين جثين الـ topology في
+
+11
+00:01:00,030 --> 00:01:02,450
+عندنا الـ star في عندنا الـ bus في عندنا الـ ring و
+
+12
+00:01:02,450 --> 00:01:04,970
+في عندنا الـ mesh اللي بتجمع ما بين الجامعات كلهم
+
+13
+00:01:04,970 --> 00:01:08,910
+لكن احنا مركزين في الـ .. هان لإن احنا بنشتغل
+
+14
+00:01:08,910 --> 00:01:12,070
+قاعدين على programming والـ concept اللي بدناياه
+
+15
+00:01:12,070 --> 00:01:15,240
+اللي بيعنينا هان واحد من التانية إما الـ peer-to
+
+16
+00:01:15,240 --> 00:01:19,380
+-peer و client-server network الـ peer-to-peer
+
+17
+00:01:19,380 --> 00:01:22,620
+اللي هي عبارة عن مجموعة من الأجهزة اللي عليها
+
+18
+00:01:22,620 --> 00:01:26,660
+مجموعة من الـ different resources وكل جهاز قائم
+
+19
+00:01:26,660 --> 00:01:30,840
+بذاته .. كل جهاز قائم بذاته وبده يعمل مشاركة
+
+20
+00:01:30,840 --> 00:01:36,460
+للأجهزة الأخرى في مقابل مشاركة هم يعملوها على الـ
+
+21
+00:01:36,460 --> 00:01:40,040
+resources اللي موجودة وقلنا مشكلة الـ peer-to-peer
+
+22
+00:01:40,040 --> 00:01:43,160
+أنه لما تكتر بيصير management بدها management أكتر
+
+23
+00:01:43,160 --> 00:01:46,180
+يعني الآن هضربنا مثلا لو كان في عندي عشر أجهزة
+
+24
+00:01:46,180 --> 00:01:49,580
+عليها different resources عشر different resources
+
+25
+00:01:49,580 --> 00:01:52,020
+معناته على كل جهاز أنا بدي أعمل تسعين sharing
+
+26
+00:01:52,020 --> 00:01:56,740
+للأجهزة الثانية وبالتالي فيها مشكلة مع الـ
+
+27
+00:01:56,740 --> 00:02:00,200
+management الـ client-server network بجمع كل الـ
+
+28
+00:02:00,200 --> 00:02:02,880
+service في dedicated computer والـ operating
+
+29
+00:02:02,880 --> 00:02:05,960
+system لازم يكون support لعملية الـ service ..
+
+30
+00:02:05,960 --> 00:02:10,180
+server عفوا مشكلتها .. مشكلتها أن لو صار في عندي
+
+31
+00:02:10,180 --> 00:02:14,860
+fail للـ server معاكتها فقط كل الـ resources اللي
+
+32
+00:02:14,860 --> 00:02:20,710
+موجودة عندها تمام ومرينا على مصطلحات مهمة بتعنينا
+
+33
+00:02:20,710 --> 00:02:25,610
+على مستوى الـ programming الـ host هو كل جهاز بياخد
+
+34
+00:02:25,610 --> 00:02:29,010
+IP address أو كل جهاز موجود على الشبكة وبياخد IP
+
+35
+00:02:29,010 --> 00:02:32,470
+address وإن كنا دائما بنتكلم بالدرجة الأولى على
+
+36
+00:02:32,470 --> 00:02:36,190
+جهاز الكمبيوتر لكن ممكن هذا الـ host يكون عبارة عن
+
+37
+00:02:36,190 --> 00:02:40,190
+router أو fax أو smartphone حسب الشبكة اللي موجودة
+
+38
+00:02:40,190 --> 00:02:44,850
+عندها كل host موجود على الشبكة له IP address
+
+39
+00:02:44,850 --> 00:02:46,150
+unique IP address
+
+40
+00:02:49,460 --> 00:02:52,460
+وقلنا في عندنا domain name system مهم تربط الـ IP
+
+41
+00:02:52,460 --> 00:02:56,160
+address مع الـ host name واتكلمنا إنه في عند الـ
+
+42
+00:02:56,160 --> 00:02:59,100
+board الآن الجهاز الواحد ممكن يكون عليه أكتر من 
+
+43
+00:02:59,100 --> 00:03:03,120
+service وهو بياخد IP address واحد على الشبكة عشان
+
+44
+00:03:03,120 --> 00:03:06,240
+يكون في عندي أكتر من service على نفس الـ IP address
+
+45
+00:03:06,240 --> 00:03:10,660
+نتكلم على إيش؟ على مصطلح الـ boards وطبعا عدد الـ
+
+46
+00:03:10,660 --> 00:03:14,520
+boards كبير جدا حوالي 65 ألف board ممكن يكون عندي
+
+47
+00:03:14,520 --> 00:03:18,510
+على الجهاز المصطلح الرابع والمهم هو الـ Protocol
+
+48
+00:03:18,510 --> 00:03:22,890
+الـ Protocol هو عبارة عن القانون اللي بيحكم تراسل
+
+49
+00:03:22,890 --> 00:03:26,570
+أو نقل البيانات بين الأجهزة أو بين الـ hosts اللي
+
+50
+00:03:26,570 --> 00:03:30,990
+موجودين عنده على الشبكة وشوفنا مجموعة من الـ ..
+
+51
+00:03:30,990 --> 00:03:33,930
+يعني احنا بيستخدم الـ HTTP الـ Hyper Text Transfer
+
+52
+00:03:33,930 --> 00:03:37,350
+Protocol بشكل يومي تقريبا، كمان؟ وهذا من أشهر الـ
+
+53
+00:03:37,350 --> 00:03:42,210
+protocols اللي موجودة وبدينا نتكلم على الـ Network
+
+54
+00:03:42,210 --> 00:03:45,490
+Programming قدمنا إليها لما أنا بدي أتكلم على
+
+55
+00:03:45,490 --> 00:03:50,150
+برمجة شبكات بتكلم على أنه أنا بدي أتكلم .. أو
+
+56
+00:03:50,150 --> 00:03:52,730
+بسميها في الـ Network Programming Security
+
+57
+00:03:52,730 --> 00:03:57,250
+Programming أو Client Server Programming على الرغم
+
+58
+00:03:57,250 --> 00:04:00,670
+أن الجهازين ممكن يكونوا مشبوكين ومافيش ولا واحد
+
+59
+00:04:00,670 --> 00:04:04,190
+يهم Server لكن من ناحية implementation للشغل تبعنا
+
+60
+00:04:04,190 --> 00:04:07,170
+اللي احنا بتتكلم عليه احنا بتتبع الـ Client Server
+
+61
+00:04:07,170 --> 00:04:11,700
+Architecture وبالتالي الـ connection عندي أو في الـ
+
+62
+00:04:11,700 --> 00:04:15,100
+network programming أما أنا بدي اروح باتجاه شغل
+
+63
+00:04:15,100 --> 00:04:19,120
+اسمه connection oriented تمام؟ أو connectionless
+
+64
+00:04:19,120 --> 00:04:22,260
+connection oriented يعني أنا بدائما الـ connection
+
+65
+00:04:22,260 --> 00:04:26,100
+يكون established مائة في المائة وبدي أتأكد أنه
+
+66
+00:04:26,100 --> 00:04:28,560
+دائما بدي احصل على acknowledgement أن الـ data وصلت
+
+67
+00:04:28,560 --> 00:04:32,520
+بشكلها الصحيح وطبعا هذا بهمني أنا موثوقية
+
+68
+00:04:32,520 --> 00:04:36,000
+البيانات أكثر من السرعة من الـ delivery time بينما
+
+69
+00:04:36,000 --> 00:04:39,980
+في الـ connectionless تمام؟ أنا بدور على الـ UDP
+
+70
+00:04:39,980 --> 00:04:43,640
+protocol وبهمني بالدرجة الأولى الـ delivery أكتر
+
+71
+00:04:43,640 --> 00:04:47,000
+من الـ quality تمام؟ تبع الـ data اللي موجودة عندنا
+
+72
+00:04:48,430 --> 00:04:51,490
+وبدأنا بما أنه الـ network programming يمكن تسمى
+
+73
+00:04:51,490 --> 00:04:55,510
+socket programming قلنا الـ socket هي عبارة عن end
+
+74
+00:04:55,510 --> 00:05:00,950
+point نقطة نهاية لإيش؟ of the bidirectional
+
+75
+00:05:00,950 --> 00:05:08,030
+communication flow يعني بنجوزين هي وصلة استقبال وإرسال 
+
+76
+00:05:08,030 --> 00:05:12,570
+للـ data هي مقطع أو الجزئية الخاصة بإرسال
+
+77
+00:05:12,570 --> 00:05:16,710
+واستقبال الـ data أو الطرفية الخاصة أو المسئولة عن
+
+78
+00:05:16,710 --> 00:05:20,190
+إرسال واستقبال الـ data في الجهاز أو في الشبكة اللي
+
+79
+00:05:20,190 --> 00:05:27,310
+موجودة عندها الآن لو احنا تخيلنا الجملة اللي بإيدي
+
+80
+00:05:27,310 --> 00:05:34,190
+هذا الآن high socket كل شغلة بتقدر توصليها في
+
+81
+00:05:34,190 --> 00:05:36,790
+بعضها بشكل محترم
+
+82
+00:05:37,870 --> 00:05:41,230
+Socket، الآن أحيانا لما بنقطع سلك الكهربا كتير من
+
+83
+00:05:41,230 --> 00:05:44,670
+الناس بروح بساوي، بروح بلفوا على بعض وهيك وب ..
+
+84
+00:05:44,670 --> 00:05:48,450
+وبال ..الـ plastic أو الـ tip أو اللاصق الـ
+
+85
+00:05:48,450 --> 00:05:50,990
+plastic عشان يعزل الكهربا وتمشي الحال لأن هذا
+
+86
+00:05:50,990 --> 00:05:53,810
+الشغل مش شغل professional الأصل أنه أنا فيه عندي
+
+87
+00:05:53,810 --> 00:05:56,830
+بعض القطع الصغيرة اللي بقدر أعمل من خلالها التوصيل
+
+88
+00:05:56,830 --> 00:05:59,910
+وأربط السلك بشكل محترم وأحافظ على سلامتي وسلامة
+
+89
+00:05:59,910 --> 00:06:03,110
+أهل البيت إلى آخرهم هذه الواصلات الصغيرة اللي
+
+90
+00:06:03,110 --> 00:06:06,330
+بالشكل هذه اللي تكون مكونة من مقطعين كلها تسمى
+
+91
+00:06:06,330 --> 00:06:09,730
+socket حتى فيشة الكهربا اللي بنتعامل معاها احنا في
+
+92
+00:06:09,730 --> 00:06:13,510
+البيوت هي socket والـ socket دائما مقطعين عشان هيك
+
+93
+00:06:13,510 --> 00:06:18,770
+هي اسمها يا شي Bidirectional يعني بترسل وبتستقبل
+
+94
+00:06:18,770 --> 00:06:23,670
+وإلا كان سميناها unidirectional لو كانت باتجاه واحد طبعا وإلا
+
+95
+00:06:23,670 --> 00:06:27,970
+كنا سميناها unidirectional الآن bidirectional معناته أن هذه
+
+96
+00:06:27,970 --> 00:06:31,350
+النقطة أو هذه الواصلة أنا بدي أشبكها مع الطرف
+
+97
+00:06:31,350 --> 00:06:36,110
+الثاني مع الـ end point الثانية عشان أقدر أرحل أنجل
+
+98
+00:06:36,110 --> 00:06:41,040
+بيانات بالاتجاهين بين الأجهزة اللي موجودة عندها الـ
+
+99
+00:06:41,040 --> 00:06:44,900
+socket هي عبارة عن ميكانيزم أو توفير لقالية من أجل
+
+100
+00:06:44,900 --> 00:06:49,720
+توصيل البيانات اللي جاية من الـ local device للـ
+
+101
+00:06:49,720 --> 00:06:53,220
+remote والعكس صحيح يعني هي عبارة عن ميكانيزم to
+
+102
+00:06:53,220 --> 00:07:01,500
+deliver data to deliver data الآن في مفهوم الـ
+
+103
+00:07:01,500 --> 00:07:08,400
+socket بدي أفهم كمان أن الـ socket بتخدش الـ data
+
+104
+00:07:08,400 --> 00:07:12,020
+كلها وبترميها مرة واحدة بدي أرجع معاك خطوتين للخلف
+
+105
+00:07:12,020 --> 00:07:16,160
+لما تكلمنا عن الـ files قلت أنا في عندي الـ memory
+
+106
+00:07:16,160 --> 00:07:21,320
+تبع الجهاز والـ application والـ data تبعها
+
+107
+00:07:21,320 --> 00:07:27,700
+موجودة فيها وفي عندي إيش الـ disk الـ hard disk من
+
+108
+00:07:27,700 --> 00:07:31,860
+أجل التخزين أقول لها أنا بتعامل مع الـ data chunk
+
+109
+00:07:33,400 --> 00:07:37,620
+مصبوط وهان بتعامل مع الـ byte أو الـ bit بيت خلينا
+
+110
+00:07:37,620 --> 00:07:41,740
+نسميها أسهل الـ chunk مجموعة من الـ bytes مجموعة
+
+111
+00:07:41,740 --> 00:07:45,020
+كبيرة من الـ bytes وهان بتتعامل مع byte بيت طيب
+
+112
+00:07:45,020 --> 00:07:50,500
+مافيش مجال أنا أرحل الـ data من هيك فكنت بحتاج
+
+113
+00:07:50,500 --> 00:07:56,160
+لوسيط هان فكنت بروح باستخدم buffered reader على سبيل
+
+114
+00:07:56,160 --> 00:08:04,630
+المثال عشان أتعامل مع الـ memory as a chunk والـ
+
+115
+00:08:04,630 --> 00:08:08,530
+buffer reader هذا كنت بقرأه أو بابنيه لما بدي أقرأ
+
+116
+00:08:08,530 --> 00:08:12,370
+من ملف بابنيه على إيش؟ على file input stream
+
+117
+00:08:12,370 --> 00:08:16,070
+مظبوط؟
+
+118
+00:08:16,070 --> 00:08:20,870
+إيش means الـ file input stream؟
+
+119
+00:08:20,870 --> 00:08:25,290
+كان بتعمل بكتب بالـ bytes يعني بين جثين كنت أنا
+
+120
+00:08:25,290 --> 00:08:28,650
+بروح أنا كـ application بكتب في الـ buffer بكتب الـ
+
+121
+00:08:28,650 --> 00:08:32,480
+chunk والـ buffer بيروح بمرر الـ data الـ chunk
+
+122
+00:08:32,480 --> 00:08:35,260
+تبعته للـ file input stream والـ file input stream
+
+123
+00:08:35,260 --> 00:08:38,940
+بيصير جدرهم byte byte على مين الـ disk حسب قدرته
+
+124
+00:08:38,940 --> 00:08:42,900
+تمامًا نفس الكلام الآن لو أنا افترض أن في عندي
+
+125
+00:08:42,900 --> 00:08:51,580
+جهازين host A وhost B موجودين على الشبكة وفي
+
+126
+00:08:51,580 --> 00:08:55,980
+بينهم خط physical connection طب ما هو الـ physical
+
+127
+00:08:55,980 --> 00:08:59,080
+connection كمان له limit بيسميها هنا الـ bandwidth
+
+128
+00:09:00,020 --> 00:09:03,700
+مصبوط وبتكلم على الـ data transfer rate تبعته قد ايش
+
+129
+00:09:03,700 --> 00:09:08,400
+بقدر أحسبها طيب تخيلي أن والله أنا ممكن أتكلم على
+
+130
+00:09:08,400 --> 00:09:12,700
+أن الـ data transfer rate تبع شبكتي 256
+
+131
+00:09:12,700 --> 00:09:19,940
+kilo byte per second والـ
+
+132
+00:09:19,940 --> 00:09:25,920
+data اللي أنا بده أرحلها 4 ميجا تقدرش اروح أرمل 4
+
+133
+00:09:25,920 --> 00:09:29,580
+ميجا مرة واحدة كـ application أنا أنا خلاص الـ data
+
+134
+00:09:29,580 --> 00:09:32,720
+عندي send يعني send انتهى أمرها طب مين مسئول أنه
+
+135
+00:09:32,720 --> 00:09:36,820
+يجزألي إياها ويتماشي بحيث أنها تتوافق مع الـ
+
+136
+00:09:36,820 --> 00:09:39,200
+bandwidth اللي موجودة على الشبكات؟ هذه شغل الـ
+
+137
+00:09:39,200 --> 00:09:42,120
+socket يعني هو كأنه الـ socket تبع الـ socket هي
+
+138
+00:09:42,120 --> 00:09:46,560
+صندوق البريد تبعي بيقول اتفضلي هي الـ data بعد هيك
+
+139
+00:09:46,560 --> 00:09:50,440
+بدها تطلع شوية شوية بدها تطلع كلها حسب قدرة الشبكة
+
+140
+00:09:50,440 --> 00:09:54,500
+والـ protocol اللي مستخدم أنا ما بعدنيش وبالتالي
+
+141
+00:09:54,500 --> 00:09:58,620
+هي عشان هي نسميها end point bidirectional
+
+142
+00:09:58,620 --> 00:10:03,560
+interconnection process الآن الـ data اللي ترسل
+
+143
+00:10:03,560 --> 00:10:10,520
+طبعا هاروح أنا باتجاه الـ TCP/IP protocol لأنه عندما
+
+144
+00:10:10,520 --> 00:10:15,640
+أتكلم عن الـ UDP نسميها الـ Data Gram Socket في
+
+145
+00:10:15,640 --> 00:10:20,420
+الـ UDP نسميها Data Gram Socket نذهب باتجاه الـ
+
+146
+00:10:20,420 --> 00:10:26,420
+TCP Socket الآن في الـ TCP Socket الـ Data Grant
+
+147
+00:10:26,420 --> 00:10:31,620
+أو مصطلح الـ Data Grant أن الـ Data تبعتي تتجسم
+
+148
+00:10:31,620 --> 00:10:37,540
+لمجموعة من الـ buckets نسميها Data Grants حجمها 
+
+149
+00:10:37,540 --> 00:10:38,820
+بيصير بيصير
+
+150
+00:10:41,890 --> 00:10:45,110
+وغالباً الـ sockets في الموضوع هذا بتتفاهم مع ال
+
+151
+00:10:45,110 --> 00:10:48,930
+transfer protocol أو مع الـ protocol المستخدم مش
+
+152
+00:10:48,930 --> 00:10:51,890
+إحنا اتفقنا سابقاً أن الـ protocol هو عبارة عن
+
+153
+00:10:51,890 --> 00:10:55,270
+الآلية التي تحكم عملية الاتصال أو ترسل البيانات
+
+154
+00:10:55,270 --> 00:11:01,390
+ما بين الأجهزة من ضمنها جداش حجم الـ data اللي بدها
+
+155
+00:11:01,390 --> 00:11:05,510
+تبعث أو ترسل من بين الطرفين وبالتالي الـ data
+
+156
+00:11:05,510 --> 00:11:10,390
+grams هي عبارة عن bucket with finite size with
+
+157
+00:11:10,390 --> 00:11:16,150
+finite size ليش vary؟ ممكن حجمها يختلف لأن لو كان
+
+158
+00:11:16,150 --> 00:11:20,430
+اللي عندي أنا واحد
+
+159
+00:11:20,430 --> 00:11:27,390
+على سبيل المثال فاصلة اثنين من عشرة تلاتة من عشرة
+
+160
+00:11:27,390 --> 00:11:34,630
+ميجا بايت وبدي أجسمهم على buckets أو data grams
+
+161
+00:11:34,630 --> 00:11:43,120
+حجمها 256 بايت كيلو بايت 256 كيلو بايت على 256
+
+162
+00:11:43,120 --> 00:11:49,600
+الواحد ميجا هتكون جداش؟ أربعة packets أربعة دلوقتي
+
+163
+00:11:49,600 --> 00:11:53,460
+gram packets، مظبوط؟ الألف و أربعة و عشرين، كم 256
+
+164
+00:11:53,460 --> 00:11:57,240
+فيها؟
+
+165
+00:11:57,240 --> 00:12:03,660
+ثمانية؟ أربعة،
+
+166
+00:12:03,660 --> 00:12:07,960
+أربعة packets، طيب، ضال عند التلاتة من عشرة الـ 3 من
+
+167
+00:12:07,960 --> 00:12:11,520
+10 فهيك صاروا كمان bucket خمسة وظل في عندي تقريباً
+
+168
+00:12:11,520 --> 00:12:17,540
+نص من مية، تمام؟ هذا بيجيش، يعني مش هيكسكر bucket
+
+169
+00:12:17,540 --> 00:12:22,200
+كاملة، عشان هيك بيقول إحنا ممكن إيش، تختلف بالحجم
+
+170
+00:12:22,200 --> 00:12:27,930
+لكن الحجم هذا إيش، finite، محدود أو محدد بشكل مؤقت.
+
+171
+00:12:28,110 --> 00:12:30,850
+إيش الميزة في التقسيم أو إيش الحكمة من تقسيم الـ
+
+172
+00:12:30,850 --> 00:12:34,110
+data هنا؟ لأنه هيتكلمنا مع الـ TCP protocol أو مع
+
+173
+00:12:34,110 --> 00:12:38,370
+الـ connection oriented بهمن لـ quality تبعت الـ data
+
+174
+00:12:38,370 --> 00:12:41,730
+بهمن الـ assurance إن أضمن إن الـ data وصلت بشكلها
+
+175
+00:12:41,730 --> 00:12:45,230
+الصحيح وبالتالي أنا مقدرش أرسل البيانات كلها مرة
+
+176
+00:12:45,230 --> 00:12:49,430
+واحدة وبعدها بيقولوا استلمت كل البيانات لا ما
+
+177
+00:12:49,430 --> 00:12:53,310
+استلمتش، بدو يرجع لسيرها مرة ثانية، حجمها كبير
+
+178
+00:12:53,310 --> 00:12:56,010
+يعني بدو .. في عندي data transfer time كبير جداً
+
+179
+00:12:56,010 --> 00:12:59,670
+لحجم الـ data فإيش الحل؟ الحل صير أبعثها bucket
+
+180
+00:12:59,670 --> 00:13:03,250
+bucket ومع كل bucket الـ bucket هاي استلمتها صحيحة
+
+181
+00:13:03,250 --> 00:13:05,950
+ولا مش صحيحة وهو الطرف الثاني بيبدأ يجمع ال
+
+182
+00:13:05,950 --> 00:13:09,880
+buckets بعد هيك وبيجمع الملف بشكل صحيح وهذا الـ
+
+183
+00:13:09,880 --> 00:13:14,320
+main advantage اللي موجودة يعني لو صار في loss في
+
+184
+00:13:14,320 --> 00:13:18,800
+الـ data وضريت أرسل مش هتضرر أرسل كل الـ data هرسل
+
+185
+00:13:18,800 --> 00:13:23,520
+الجزئية اللي صار فيها loss الـ socket فيها ميزة
+
+186
+00:13:23,520 --> 00:13:28,780
+ثانية كمان أنها بتعزل الـ programmer عن الـ network
+
+187
+00:13:28,780 --> 00:13:32,000
+architecture والـ implementation تبعتها كلها إحنا
+
+188
+00:13:32,000 --> 00:13:37,110
+هنشوف كمان شوية من خلال code أن أنا فعلياً مش
+
+189
+00:13:37,110 --> 00:13:41,230
+بتعاملش مع شبكات كل اللي بيلزمني أن أكون فاهم مصطلح
+
+190
+00:13:41,230 --> 00:13:44,770
+الشبكة شو يعني IP address شو يعني port شو يعني
+
+191
+00:13:44,770 --> 00:13:49,510
+socket وبيصير من خلال الـ socket أعمل create لـ input
+
+192
+00:13:49,510 --> 00:13:52,130
+stream وoutput stream وكان الله بالسر عليهم و
+
+193
+00:13:52,130 --> 00:13:55,510
+أصير أكتب على الـ input stream اللي موجود عندي أكتب
+
+194
+00:13:55,510 --> 00:14:01,650
+وأقرأ زي ما كنت أتعامل مع الملفات تمام وبالتالي
+
+195
+00:14:01,650 --> 00:14:04,150
+الـ socket isolated programming from details
+
+196
+00:14:04,150 --> 00:14:06,850
+bucket encoding ولا لسطه كل الشغلات هذه أنت
+
+197
+00:14:06,850 --> 00:14:10,890
+مابتعنيكيش ولا حاجة فيها الـ socket هي عبارة عن
+
+198
+00:14:10,890 --> 00:14:15,790
+reliable connection for transmission of data خط
+
+199
+00:14:15,790 --> 00:14:21,530
+صال موثوق ما بين العناصر الموجودة ولو طلعنا فعلياً
+
+200
+00:14:21,530 --> 00:14:24,750
+في الـ structure بين two hosts اللي بدهم يتراسلوا
+
+201
+00:14:24,750 --> 00:14:28,970
+في البيانات أنت هذه الـ application تبعك والنقطة
+
+202
+00:14:28,970 --> 00:14:29,770
+الزرقاء هي الـ socket
+
+203
+00:14:32,840 --> 00:14:37,180
+وهذا غالباً محكم بـ Developer أنت كـ برمجر أنت هاني
+
+204
+00:14:37,180 --> 00:14:41,100
+بتشتغلي وبتعملي الـ connection عشان يكسب منها end
+
+205
+00:14:41,100 --> 00:14:44,480
+point والجزئية الـ TCP والـ buffer والـ
+
+206
+00:14:44,480 --> 00:14:47,720
+communication الثانية شغل الـ operating system أنت
+
+207
+00:14:47,720 --> 00:14:51,580
+مالكيش عليها دخل أحيانا تتدخل بتفضل بتقول بدي أزيد
+
+208
+00:14:51,580 --> 00:14:55,280
+أو أقل الحجم للـ bucket كـ request والـ operating
+
+209
+00:14:55,280 --> 00:14:58,200
+system هو في الآخر المسؤول عن كل الـ implementation
+
+210
+00:14:58,200 --> 00:15:02,360
+كذلك الطرفين الثاني ليش أنا بتكلم الآن على طرفين؟
+
+211
+00:15:02,360 --> 00:15:04,840
+لأن الأصل واحد فيهم يكون client والثاني يكون
+
+212
+00:15:04,840 --> 00:15:09,390
+server يعني واحد يقدم خدمة والثاني يستفيد منها إيش
+
+213
+00:15:09,390 --> 00:15:12,790
+الشغلات اللي ممكن الـ developer يحاول يتعامل فيها
+
+214
+00:15:12,790 --> 00:15:16,690
+مع الـ TCP protocol الـ maximum buffer وجداش ال
+
+215
+00:15:16,690 --> 00:15:19,310
+segment size جداش حد من الـ segment أو الـ data
+
+216
+00:15:19,310 --> 00:15:22,550
+bucket اللي أنا بدي أتعامل معاها بشكل عام ال
+
+217
+00:15:22,550 --> 00:15:25,830
+secret operations أربع عمليات عملية connection
+
+218
+00:15:25,830 --> 00:15:28,890
+كنتوا رقم واحد زي ما شوفنا في الـ database
+
+219
+00:15:28,890 --> 00:15:33,730
+registration connection statement execution بصبت وبعد
+
+220
+00:15:33,730 --> 00:15:36,090
+هيك الـ fetching للـ data هي نفس الكلام
+
+221
+00:15:36,090 --> 00:15:41,860
+connection تمام؟ send يعني في عندي output stream،
+
+222
+00:15:41,860 --> 00:15:46,060
+receive يعني عندي input stream، مظبوط؟ والـ close
+
+223
+00:15:46,060 --> 00:15:50,520
+وخلصت العملية اللي موجودة عندي بكل بساطة يعني
+
+224
+00:15:50,520 --> 00:15:54,560
+عندي أربع عمليات المفروض تتوفر في الـ socket أو في
+
+225
+00:15:54,560 --> 00:15:56,740
+الـ server أو في الـ .. عفوا .. في الـ network
+
+226
+00:15:56,740 --> 00:16:02,350
+program تطبق العمليات اللي موجودة عندها الـ
+
+227
+00:16:02,350 --> 00:16:04,830
+connection بتتم من خلال الـ socket الـ connection
+
+228
+00:16:04,830 --> 00:16:08,570
+بتتم من خلال الـ socket والـ socket constructor
+
+229
+00:16:08,570 --> 00:16:12,930
+مش بس بينشغلي socket object ولأ بيحاول يعمل اتصال
+
+230
+00:16:12,930 --> 00:16:17,090
+مباشر مع الـ IP address اللي أنا بدي أحدده مع ال
+
+231
+00:16:17,090 --> 00:16:22,930
+server طيب إيش الـ programmer اللي بيلزمه عشان
+
+232
+00:16:22,930 --> 00:16:26,690
+ينشغل socket بيلزمني أعرف مين الـ server اللي أنا
+
+233
+00:16:26,690 --> 00:16:31,470
+بدي أتصل عليه من خلال اسمه أو الـ IP address وإيش
+
+234
+00:16:31,470 --> 00:16:35,290
+الـ port الـ service اللي أنا بدي إياها وبدي أعمل
+
+235
+00:16:35,290 --> 00:16:41,170
+عليها اتصال يعني بيلزمني remote host IP address أو
+
+236
+00:16:41,170 --> 00:16:45,410
+name وبيلزمني الـ port عشان أتصل معاه طبعاً الـ host
+
+237
+00:16:45,410 --> 00:16:50,450
+ممكن أستخدم الـ IP address وممكن أستخدم الـ name
+
+238
+00:16:50,450 --> 00:16:54,130
+تبعتها اسم الـ computer أو أستخدم الـ IP address حسب
+
+239
+00:16:54,130 --> 00:16:58,920
+الحاجة طبعاً في عندي الـ int address class Int
+
+240
+00:16:58,920 --> 00:17:03,200
+Address Class بيوفر لي مجموعة من الـ methods بحيث أو
+
+241
+00:17:03,200 --> 00:17:06,360
+two method بالدرجة الأولى بيشتغل شغل الـ DNS الـ
+
+242
+00:17:06,360 --> 00:17:11,240
+system بدي الـ IP address وبقول للـ DNS إيش هتلي
+
+243
+00:17:11,240 --> 00:17:16,060
+الـ name أو العكس صحيح أو العكس صحيح عشان أنشئ
+
+244
+00:17:16,060 --> 00:17:20,900
+socket بعرف socket الـ class اسم الـ socket new
+
+245
+00:17:20,900 --> 00:17:25,530
+socket وبزودها زي ما قلنا بشغلتين أساسيات بالـ
+
+246
+00:17:25,530 --> 00:17:29,390
+Remote IP Address اللي هو الـ Server IP Address أو
+
+247
+00:17:29,390 --> 00:17:33,290
+الـ Host Name تبع الـ Remote Address بالإضافة للـ
+
+248
+00:17:33,290 --> 00:17:38,170
+port اللي موجود عندها تعال
+
+249
+00:17:38,170 --> 00:17:41,710
+نشوف إيش المفروض أو إيش السيناريو اللي بيصير عندها
+
+250
+00:17:41,710 --> 00:17:45,370
+في الشغل إحنا اتفقنا أن الـ concept تبعتنا Client
+
+251
+00:17:45,370 --> 00:17:49,510
+-Server Architecture Client-Server Architecture
+
+252
+00:17:49,510 --> 00:17:54,550
+وأنا بتكلم على الـ socket أو الـ TCP socket هي الـ
+
+253
+00:17:54,550 --> 00:17:58,670
+server-side وهي الـ client-side المفروض أن الـ
+
+254
+00:17:58,670 --> 00:18:02,710
+server-side يكون موجود وشغال إيش يعني؟ يعني في
+
+255
+00:18:02,710 --> 00:18:06,130
+عنده server أو في عنده socket بينشئ socket ويعمل
+
+256
+00:18:06,130 --> 00:18:10,250
+bind يربطها بالـ port ويعمل listening بناء على
+
+257
+00:18:10,250 --> 00:18:15,330
+عملية الـ binding اللي صارت الـ client الآن بده يروح
+
+258
+00:18:15,330 --> 00:18:19,810
+ينشئ socket ويُزودها بالـ IP address ويحاول يعمل
+
+259
+00:18:19,810 --> 00:18:24,590
+connection connection مع مين؟ مع الـ server بناء
+
+260
+00:18:24,590 --> 00:18:27,630
+على الـ IP address تبع الـ server والـ port اللي
+
+261
+00:18:27,630 --> 00:18:32,430
+عمله by him فبعد بعد request لأن والله إذا ال
+
+262
+00:18:32,430 --> 00:18:38,850
+server هذا عمل accept تمام فبرجع له وبقول okay
+
+263
+00:18:38,850 --> 00:18:42,970
+accepted accepted معناته okay مسموح لكن أنت الآن
+
+264
+00:18:42,970 --> 00:18:48,560
+ترسل وتستقبل الـ data وبتصير كل عملية send في
+
+265
+00:18:48,560 --> 00:18:53,620
+مقابلها receive وكل عملية send من جهة الـ server
+
+266
+00:18:53,620 --> 00:19:00,040
+هتقبلها receive عند وين؟ عند الـ client وهكذا طيب،
+
+267
+00:19:00,040 --> 00:19:05,420
+الآن هذا الكلام تماماً زي لو أنت بدك تتصل على
+
+268
+00:19:05,420 --> 00:19:10,160
+زميلتك باستخدام مثل الـ mobile حطيت رقمها وبمثابة
+
+269
+00:19:10,160 --> 00:19:15,520
+الـ IP address وحددت الشريحة لو أنت فرض تستخدم جوال
+
+270
+00:19:15,520 --> 00:19:18,920
+أو موبايل أو وطنية تمام حددت الـ port اللي أنت
+
+271
+00:19:18,920 --> 00:19:24,400
+بتتصل من خلاله واتصال الآن
+
+272
+00:19:24,400 --> 00:19:30,020
+لأ أنت حددت رقمها وطنية أو جوال عشان ما ثابت الـ
+
+273
+00:19:30,020 --> 00:19:32,100
+port اللي أنت عمال بتتصل يا معاها شريحتين أن هي
+
+274
+00:19:32,100 --> 00:19:36,440
+وأنت عمالك بتحدد على أي شريحة بتتصلي لأن رن الجوال
+
+275
+00:19:36,440 --> 00:19:42,200
+عندها عندها الحق أن هي accept or reject مظبوط
+
+276
+00:19:42,200 --> 00:19:45,600
+مشغولة بتعمل cancel المكالمة يعني عملت reject بدها
+
+277
+00:19:45,600 --> 00:19:48,120
+تكمل الـ conversation أو تبني الحوار معاكي بتعمل
+
+278
+00:19:48,120 --> 00:19:52,680
+accept وبتبدأ ترسلوا البيانات أتوقع أن في الـ data
+
+279
+00:19:52,680 --> 00:19:57,870
+تطلع وبتُرسل في نفس الوجات إحنا أحيانا من كتر سرعة
+
+280
+00:19:57,870 --> 00:20:00,950
+نقل البيانات بنحسها synchronized بس يعني وفي 
+
+281
+00:20:00,950 --> 00:20:05,250
+delay بسيط بسيط جدا لأن الجهاز بدو يستجيب و بدو
+
+282
+00:20:05,250 --> 00:20:09,110
+يرسل و حسب يعمل ال process في كل اتجاه anyway هذا
+
+283
+00:20:09,110 --> 00:20:13,550
+الكلام هو اللي بصير هنا حتى في الشبكات الآن بعد ما
+
+284
+00:20:13,550 --> 00:20:16,410
+بنخلص الأصل أعمل close لكل ال socket اللي موجودة
+
+285
+00:20:16,410 --> 00:20:21,770
+عندهم ال application تبعي هذا احنا متعودين فيه أن
+
+286
+00:20:21,770 --> 00:20:27,280
+أنا هنا في عندي input stream من الـ keyboard صح؟
+
+287
+00:20:27,280 --> 00:20:33,790
+وفي عندي output stream على الـ monitor system. كنت
+
+288
+00:20:33,790 --> 00:20:37,450
+بتعامل مع الـ Scanner و في عندي System.out و بعمل
+
+289
+00:20:37,450 --> 00:20:41,570
+البرنت على الشاشة، مصبوط؟ و روحنا احنا لاحقا أضفنا
+
+290
+00:20:41,570 --> 00:20:45,290
+.. انسيلي هذا المكتوب .. أضفنا ال files و ببني
+
+291
+00:20:45,290 --> 00:20:47,810
+عليها input stream و output stream عشان أكتب على
+
+292
+00:20:47,810 --> 00:20:52,070
+ال file و input stream عشان أخد من ال file، الآن
+
+293
+00:20:52,070 --> 00:20:56,810
+شيلي مفهوم ال file تماما و بتحط مكانه مين؟ ال socket
+
+294
+00:20:56,810 --> 00:21:01,410
+بدي أحط مكانه ال socket مثال آخر للسكت صندوق البريد
+
+295
+00:21:01,410 --> 00:21:03,990
+اللي بيكون أو الصندوق اللي بيكون قدام الموظف على
+
+296
+00:21:03,990 --> 00:21:09,530
+مكتبه فيه رفين صغير صادر و وارد لو روحت عند العميد
+
+297
+00:21:09,530 --> 00:21:12,950
+أو عند رئيس جسمك بتلاقيه موجود غالبا الآن بيجي
+
+298
+00:21:12,950 --> 00:21:16,950
+بيكتب بيبعت رسالة بروح بكتب لمين الرسالة بكتب لمين
+
+299
+00:21:16,950 --> 00:21:20,190
+و بحطها في صندوق الصادر و بنتظر لما بيجي ساعي
+
+300
+00:21:20,190 --> 00:21:24,330
+البريد بياخدها و بروح بناء على العنوان لمين هدا
+
+301
+00:21:24,330 --> 00:21:28,830
+رايحة و بحقها وين في صندوق الوارد للشخص تبع المكتب
+
+302
+00:21:28,830 --> 00:21:32,930
+التاني والعكس صحيح لو كانت الرسائل الجاية وهو نفس
+
+303
+00:21:32,930 --> 00:21:37,570
+الكلام فأنتي لحد ال socket هيك و تمام معناته أنا
+
+304
+00:21:37,570 --> 00:21:40,770
+في عندي input و output stream على ال socket و بده
+
+305
+00:21:40,770 --> 00:21:46,090
+أصير اكتبها أني ايش بصير لاحقا؟ هدم الشغل لل
+
+306
+00:21:46,090 --> 00:21:49,090
+operating system وبالتالي أنا isolated عنه تماما
+
+307
+00:21:50,310 --> 00:21:54,490
+تعالى نشوف فعليا ايش اللي لازم يصير لو أنا بدي
+
+308
+00:21:54,490 --> 00:21:58,590
+اعمل implementation لأن أنا لازم ابدأ بال server
+
+309
+00:21:58,590 --> 00:22:01,750
+-side اعمله implementation لازم أبدأ بال server
+
+310
+00:22:01,750 --> 00:22:07,170
+-side ليش؟ لأنه من خلاله بدي احدد ال port اللي
+
+311
+00:22:07,170 --> 00:22:10,910
+بدي نعمل عليه على listening فبالتالي لازم يكون ال
+
+312
+00:22:10,910 --> 00:22:15,360
+server available قبل ما كل client طيب بروح بعمل
+
+313
+00:22:15,360 --> 00:22:19,300
+create لـ socket و بحدد port و عمال بعمل
+
+314
+00:22:19,300 --> 00:22:23,100
+listening لمين؟ لل request اللي جاية طبعا ال
+
+315
+00:22:23,100 --> 00:22:27,020
+server في عندي شغل اسمه server socket special
+
+316
+00:22:27,020 --> 00:22:31,080
+socket اسمه ال server socket تمام و بيعمل
+
+317
+00:22:31,080 --> 00:22:36,840
+listening تمام إذا إجا request و جبله تمام بروح
+
+318
+00:22:36,840 --> 00:22:41,020
+بعمل create ل socket جديدة والسكت هادي يعني وكأن
+
+319
+00:22:41,020 --> 00:22:44,960
+وكأن أنا جبلت اتصالك اروح شبكتك تماما مع مين؟ مع
+
+320
+00:22:44,960 --> 00:22:51,100
+الخاطر تماما مثل موظف البدالة لو أنت اتصلت من بيتك
+
+321
+00:22:51,100 --> 00:22:55,380
+أو من خارج الجامعة على رقم الجامعة الاتصال لمين
+
+322
+00:22:55,380 --> 00:22:58,400
+بيورد؟ بيرد للبدالة تبع الجامعة اللي هو مقسم
+
+323
+00:22:58,400 --> 00:23:01,800
+الاتصالات الداخلية الآن بقولك اديني الرقم
+
+324
+00:23:01,800 --> 00:23:06,300
+التليفوني الداخلي عشان احولك على الموظف اللي بدك
+
+325
+00:23:06,300 --> 00:23:11,310
+فيه اللي هو مثابة ال port الآن بمجرد أنت حددت ال
+
+326
+00:23:11,310 --> 00:23:13,690
+port أو ال connection بشكل صحيح و established
+
+327
+00:23:13,690 --> 00:23:19,130
+خلاص أنت صرت على خط مستقل في اتصال مباشر مع ال
+
+328
+00:23:19,130 --> 00:23:22,570
+target phone وبالتالي الـ Bad guy لسه ممكن تستقبل
+
+329
+00:23:22,570 --> 00:23:26,490
+كمان مكالمة وتالتة ورابعة وعشرة حسب قدرتها في
+
+330
+00:23:26,490 --> 00:23:30,330
+المكالمات اللي موجودة وبالتالي كل connection بيجي
+
+331
+00:23:30,330 --> 00:23:35,370
+بينعمل له data أو socket جديدة عشان تبدأ تقدر تكتب
+
+332
+00:23:35,370 --> 00:23:38,430
+وتلجأ بيانات لأن ال server socket هذه ما بترسلش و
+
+333
+00:23:38,430 --> 00:23:42,290
+مابتستقبلش بيانات ال server socket ما بتستقبل ولا
+
+334
+00:23:42,290 --> 00:23:46,030
+بترسل بيانات مهمتها بس تعمل listening لل income
+
+335
+00:23:46,030 --> 00:23:53,100
+request طيب وبعد هيك معناته أنا في المرحلة هذه بدي
+
+336
+00:23:53,100 --> 00:23:56,760
+أنا بهمني ال client صار هذا جاهز بغض النظر ايه ال
+
+337
+00:23:56,760 --> 00:23:59,700
+processing اللي بده يصير فبيجي بدور ال client بنشي
+
+338
+00:23:59,700 --> 00:24:05,660
+عليه socket و بحدد لل socket هذه ال host ID اللي
+
+339
+00:24:05,660 --> 00:24:09,800
+موجود مع ال server و ال port اللي أنا حددته عشان
+
+340
+00:24:09,800 --> 00:24:11,980
+ايه قلت لك ال server لازم يكون موجود قبل و شغال
+
+341
+00:24:11,980 --> 00:24:15,400
+عشان أقدر أطلب request بعد هيك و بروح بطلب
+
+342
+00:24:15,400 --> 00:24:18,690
+request الـ request هاد بتيجي لمين؟ للـ server
+
+343
+00:24:18,690 --> 00:24:22,990
+socket في حالة ال waiting اللي بتنتظر أي request جبلته
+
+344
+00:24:22,990 --> 00:24:26,970
+عاملة establish ل connection معناته هتروح هي تعمل
+
+345
+00:24:26,970 --> 00:24:31,330
+generate هنا ل connection و يصير في عندي real
+
+346
+00:24:31,330 --> 00:24:33,790
+communication لان ما بين ال socket تبعت ال client
+
+347
+00:24:34,600 --> 00:24:37,560
+والـ socket الجديدة اللي أنشئها الـ server طب و ال
+
+348
+00:24:37,560 --> 00:24:40,200
+server شوكة ال socket اللي موجودة سابقا هتظل
+
+349
+00:24:40,200 --> 00:24:45,460
+موجودة تسمع أو تنتظر أي income request تاني و بتظل
+
+350
+00:24:45,460 --> 00:24:47,560
+هذا established ما بين ال two circuits لحد ما
+
+351
+00:24:47,560 --> 00:24:55,860
+يطوله أنت أخذت BHP صح؟ لأن ال site تبعك كم
+
+352
+00:24:55,860 --> 00:25:03,710
+session ممكن يفتح؟ كثير حسب قدرية ال server السيرفر
+
+353
+00:25:03,710 --> 00:25:06,230
+socket هذه ممكن أنا احدد لها عدد ال session عدد ال
+
+354
+00:25:06,230 --> 00:25:10,470
+connection جديدة حجم ال queue تبعتي لو أتينا .. أنا
+
+355
+00:25:10,470 --> 00:25:13,910
+حددتها عشرة و أتينا 11 connection واحد منهم هضلاش
+
+356
+00:25:13,910 --> 00:25:17,550
+يعمل wait مش هينجبل لحد ما ال connection تبعتي
+
+357
+00:25:17,550 --> 00:25:20,970
+يعني بين جثين بصير بقول أن السيرفر socket تبعتي هذه
+
+358
+00:25:20,970 --> 00:25:25,570
+تقدر تعمل generate لعشرة sockets أو عشان يتخاطبوا
+
+359
+00:25:25,570 --> 00:25:31,160
+مع عشرة clients مختلفين تعال نشوف ما يمكنني
+
+360
+00:25:31,160 --> 00:25:33,000
+استفيده من الـ socket قبل أن أشاهد الـ code في
+
+361
+00:25:33,000 --> 00:25:38,060
+الآخر الـ socket هي ال constructor بياخد ال host
+
+362
+00:25:38,060 --> 00:25:42,960
+name و بياخد ال port من خلال ال socket object أنا
+
+363
+00:25:42,960 --> 00:25:46,720
+في عنده two methods get input stream و بترجع لي
+
+364
+00:25:46,720 --> 00:25:51,600
+input stream object تمام؟ و get output stream و
+
+365
+00:25:51,600 --> 00:25:56,440
+بترجع لي output stream object تمام؟ احنا لما بجينا
+
+366
+00:25:56,440 --> 00:25:57,760
+نعرف buffer write reader
+
+367
+00:26:05,370 --> 00:26:16,590
+أنا راح أقول له new file input stream وطبعا هذا
+
+368
+00:26:16,590 --> 00:26:19,670
+كان يأخذ من ال object تبع ال file مظبوط؟ ال file
+
+369
+00:26:19,670 --> 00:26:26,450
+object ولما بتعامل مع ال buffer writer نفس الكلام
+
+370
+00:26:26,450 --> 00:26:29,290
+ال buffer writer أبني على file output stream على
+
+371
+00:26:29,290 --> 00:26:32,820
+الفايل اللي موجود عندي  نفس الكلام وبالتالي أنا
+
+372
+00:26:32,820 --> 00:26:36,760
+حصلت اللي بدي أنا من ناحية كتابة ال data وخلصتها
+
+373
+00:26:36,760 --> 00:26:41,920
+السيرفر سوكيت
+
+374
+00:26:41,920 --> 00:26:46,320
+صحيح طب الحين أنا جزدك الحين لو كان عندي أكثر من
+
+375
+00:26:46,320 --> 00:26:50,380
+client أنه بتتعامل مع client واحد ولا ال session
+
+376
+00:26:50,380 --> 00:26:52,920
+هيكون أكثر من ال client عشان .. اه لا ايوا هو
+
+377
+00:26:52,920 --> 00:26:55,560
+مفهومة كم session بده يفتح هي كل session بتمثل
+
+378
+00:26:55,560 --> 00:27:00,450
+مين؟ client كل session بتمثل client وبالتالي لما
+
+379
+00:27:00,450 --> 00:27:04,110
+أنا بقوله أنا بدي اعمل عشرة sessions كحد أقصى يعني
+
+380
+00:27:04,110 --> 00:27:06,330
+أنا باختصار عشرة clients كحد أقصى هي اللي هي
+
+381
+00:27:06,330 --> 00:27:09,750
+المفهومة وبالتالي ال server socket handle أنا بتكلم
+
+382
+00:27:09,750 --> 00:27:13,410
+على عدد ال clients أو كل ال sessions اللي ممكن
+
+383
+00:27:13,410 --> 00:27:18,650
+أفتحها بس الآن في مفهوم الـ Client-Server
+
+384
+00:27:18,650 --> 00:27:21,710
+Programming كل session تساوي client وكل client
+
+385
+00:27:21,710 --> 00:27:26,630
+يساوي session و ال session تساوي وقت معالج و سبيس
+
+386
+00:27:26,630 --> 00:27:32,110
+في ال memory عشان هيك لازم تكون limited ال
+
+387
+00:27:32,110 --> 00:27:37,190
+connection socket اللي
+
+388
+00:27:37,190 --> 00:27:43,630
+في الرسم هنا ال connection socket هي عبارة عن
+
+389
+00:27:43,630 --> 00:27:47,780
+socket من هذه تمام؟ نفس النوع by directional عشان
+
+390
+00:27:47,780 --> 00:27:51,980
+تصير في عندي data هادي ما بترسلش ولا بتستقبل data
+
+391
+00:27:51,980 --> 00:27:56,440
+الآن هاديش مهمتها تستمع لل request اللي جاي من عند
+
+392
+00:27:56,440 --> 00:28:00,880
+ال client إذا عملت له accept تعمل connection socket
+
+393
+00:28:00,880 --> 00:28:04,660
+من نفس نوع هادي عشان تقدر ترسل .. تتنسل و تتخاطبوا
+
+394
+00:28:04,660 --> 00:28:08,900
+مع بعض لأ
+
+395
+00:28:08,900 --> 00:28:13,140
+مش ضروري بحل أنه يعني ال client هذا إذا ممكن يعمل
+
+396
+00:28:13,140 --> 00:28:17,160
+أكثر من connection الـ Client الواحد أكيد لأ لأنه
+
+397
+00:28:17,160 --> 00:28:20,000
+في الآخر أنت اللي application شوفي أنت الآن بالـ
+
+398
+00:28:20,000 --> 00:28:25,100
+Java لو أنت .. أسألني مثال مع ال graphical user
+
+399
+00:28:25,100 --> 00:28:29,540
+interface عندك عملت برنامج بسيط بعمل form معينة
+
+400
+00:28:29,540 --> 00:28:33,020
+وشغلتيه مرة واثنين وثلاثة أو أربع أو خمسة أو ستة
+
+401
+00:28:33,020 --> 00:28:37,080
+تمام؟ لأن كل ال .. كل المرة شغال قدامك على الجهاز
+
+402
+00:28:37,080 --> 00:28:41,380
+مظبوطا لأ كل واحد فيهم عبارة عن session مختلفة
+
+403
+00:28:41,380 --> 00:28:45,450
+لأنه أخذ وقت من وقت المعالج و memory من memory
+
+404
+00:28:45,450 --> 00:28:48,790
+الجهاز غير عن السابق وبالتالي أنت لما بتعمله م
+
+405
+00:28:48,790 --> 00:28:52,370
+closed بتعمله م closed كل واحد بشكل مستقل، بظبط؟
+
+406
+00:28:52,370 --> 00:28:57,300
+لأن هنا نفس الكلام كل client هنا بيشتغل بيعمل
+
+407
+00:28:57,300 --> 00:29:02,480
+request هو عبارة عن new completely client حتى لو
+
+408
+00:29:02,480 --> 00:29:04,760
+كان نفس ال application و أنا المرة الجاية احنا
+
+409
+00:29:04,760 --> 00:29:07,180
+اليوم مش هنشغل عملي احنا هنقفل المفهوم كله نظري و
+
+410
+00:29:07,180 --> 00:29:09,940
+نطلع على الكود المرة الجاية بنشغل فيه عملي هتروح لي
+
+411
+00:29:09,940 --> 00:29:13,960
+أن في كل مرة بشغل ال code تبع ال client أنا بعمل
+
+412
+00:29:13,960 --> 00:29:16,340
+request على نفس ال server بيعتبر أن هنا في عندي
+
+413
+00:29:16,340 --> 00:29:21,920
+request جديد و بيعمل سكة جديدة ب port جديد عشان
+
+414
+00:29:21,920 --> 00:29:24,140
+يصير ال connection من خلال ال port الموجود
+
+415
+00:29:28,160 --> 00:29:31,340
+ما هي اللي بنقوله، كل client فيقوله connection
+
+416
+00:29:31,340 --> 00:29:35,780
+socket ممكن أكثر من connection و socket كله لنفس
+
+417
+00:29:35,780 --> 00:29:40,560
+ال client؟ لأ لأ طب مش هو كل طلب من ال client؟
+
+418
+00:29:40,560 --> 00:29:44,160
+ممتاز ال client كم مرة بيعمل الطلب؟ يعني أصلا طلب
+
+419
+00:29:44,160 --> 00:29:48,640
+تاني؟ شوية، بس أصفر شوية، الآن وأنت قاعدة بتحكي
+
+420
+00:29:48,640 --> 00:29:52,580
+على التليفون، على الجوال لو حاولتي تروح تعمل ايه؟ 
+
+421
+00:29:52,580 --> 00:29:56,640
+كمان مكالمة واتصال، ترضى؟
+
+422
+00:29:59,340 --> 00:30:03,460
+ليش؟ لازم تسكر المكالمة لأنه أنت الآن already ك
+
+423
+00:30:03,460 --> 00:30:07,500
+client عندك بس الإمكانية تعمل associate لمدة
+
+424
+00:30:07,500 --> 00:30:10,480
+مكالمة واحدة الآن مع الـ smartphone واللي بيكون 
+
+425
+00:30:10,480 --> 00:30:15,240
+عليه شريحتين طبعا بس ما يحكيش يعمل المكالمة بس ممكن
+
+426
+00:30:15,240 --> 00:30:18,280
+يخليك تستقبل مكالمة ثانية وتحط الأولى في ال
+
+427
+00:30:18,280 --> 00:30:21,880
+weight، فتح لك two different sessions مفتوحات الآن
+
+428
+00:30:21,880 --> 00:30:25,420
+وهذا هو نفس الكلام اللي بيصير عندك هنا الـ client
+
+429
+00:30:25,420 --> 00:30:30,760
+هو one session وكل client له request واحدة فقط لو
+
+430
+00:30:30,760 --> 00:30:33,300
+أنا رحت كمان مرة في الكلام الكويس لو أنا رحت
+
+431
+00:30:33,300 --> 00:30:39,460
+شغلت برنامجي عشر مرات مختلفة معناته أنا عملت عشر
+
+432
+00:30:39,460 --> 00:30:43,800
+clients مختلفين، مالهاش داعي لأن كل connection
+
+433
+00:30:43,800 --> 00:30:49,980
+بمثابة session و client مختلف. طيب، الآن قلنا لـ
+
+434
+00:30:49,980 --> 00:30:52,840
+input stream والـ output stream خلصنا عليهم من عند
+
+435
+00:30:52,840 --> 00:30:56,640
+الـ server socket الـ server socket وأهم
+
+436
+00:30:56,640 --> 00:31:00,180
+constructor لازم ياخد من مين؟ الـ board ال
+
+437
+00:31:00,180 --> 00:31:02,680
+constructor الثاني ممكن يدّي الـ board والـ maximum
+
+438
+00:31:02,680 --> 00:31:07,400
+number of connections، الـ method accept هذه بترجع ب
+
+439
+00:31:07,400 --> 00:31:12,200
+object منه إيش؟ socket اللي كانت موجودة وين؟ اللي
+
+440
+00:31:12,200 --> 00:31:15,760
+كانت موجودة عند الـ client طبعا؟ طب وعشان يعمل
+
+441
+00:31:15,760 --> 00:31:19,800
+عليها connection إيش بيلزمها؟ بيلزمها الـ host و
+
+442
+00:31:19,800 --> 00:31:23,940
+بيلزمها الـ board، من أين جابهم؟ مش شغل الشبكات هذا
+
+443
+00:31:23,940 --> 00:31:28,120
+الآن لأن كل رسالة جايانة من الـ client بتحمل الـ IP 
+
+444
+00:31:28,120 --> 00:31:30,500
+address والـ board اللي اتصل عليه فهو بياخد و
+
+445
+00:31:30,500 --> 00:31:33,640
+بيقول اتفضل هاي الجهاز اعمل connection على ال
+
+446
+00:31:33,640 --> 00:31:36,020
+board، والسوقة اللي موجودة عندي هان بدي احاول بدي 
+
+447
+00:31:36,020 --> 00:31:39,760
+اعمل zoom out، zoom out للـ code اللي موجود عندي هان
+
+448
+00:31:39,760 --> 00:31:45,940
+الـ mouse ماله؟
+
+449
+00:31:49,500 --> 00:31:56,720
+مش راضي؟ ليش طيب؟
+
+450
+00:31:56,720 --> 00:32:09,480
+بلاش نشتغل بالطريقة اللي أصعب هذه
+
+451
+00:32:09,480 --> 00:32:14,280
+الـ server-side تعالى نشوف إيش بدأنا في code هنا
+
+452
+00:32:14,280 --> 00:32:20,780
+عرفت socketServer زي ما قلت هان أنا بنيت المقسم
+
+453
+00:32:20,780 --> 00:32:24,540
+تبع الاتصالات تبع جهازي تبع الـServer الآن وحددتله
+
+454
+00:32:24,540 --> 00:32:28,720
+الرقم 6,7,8,9 الـ Board هاي الـ Board بيعمل
+
+455
+00:32:28,720 --> 00:32:32,760
+Listening الآن أي Client .. أي Client عشان يتصل
+
+456
+00:32:32,760 --> 00:32:35,460
+على الـ Server هذا بلزمه شغلتين بلزم الـ IP
+
+457
+00:32:35,460 --> 00:32:40,340
+Address أو الـ Host Name واحدة من الاثنتين والـ
+
+458
+00:32:40,340 --> 00:32:42,760
+Board الآن
+
+459
+00:32:43,840 --> 00:32:50,100
+الـ port هاي محدد عندي 6,7,8,9 أو الـ IP address حسب
+
+460
+00:32:50,100 --> 00:32:53,580
+حسب الجهاز، حسب إيش اسم الجهاز إذا أنت بتشتغل على
+
+461
+00:32:53,580 --> 00:32:57,180
+نفس الجهاز زي ما أنا بجرب عندي في البيت وعلى جهازي
+
+462
+00:32:57,180 --> 00:33:04,200
+1,2,7,0,0,1 احنا بنسميه loop back IP address أو ال
+
+463
+00:33:04,200 --> 00:33:10,040
+local host IP address، كما هدف يظل يعمل listening
+
+464
+00:33:10,040 --> 00:33:15,760
+for any income connection، فلازم تظل في infinite
+
+465
+00:33:15,760 --> 00:33:20,080
+loop لازم تظل شغال في infinite loop، while true
+
+466
+00:33:20,080 --> 00:33:25,140
+الآن while true معناته الـ code هذا هتظل شغال و
+
+467
+00:33:25,140 --> 00:33:31,240
+واقف هنا متى بنفذ الـ code اللي تحت؟ لما يصير فيه
+
+468
+00:33:31,240 --> 00:33:34,320
+request وينعمله accept طبعا احنا مش عاملين ن
+
+469
+00:33:34,320 --> 00:33:36,280
+reject هنا لأي request، أي request بيجي من هنا
+
+470
+00:33:36,280 --> 00:33:40,280
+نعمله accept مباشرة، الـ accept راح ت .. إيش عملت
+
+471
+00:33:40,280 --> 00:33:45,600
+ليه؟ سكت تمام؟ Communication socket اللي هي ال
+
+472
+00:33:45,600 --> 00:33:48,140
+socket اللي احنا عرفناها، القانع يعني بين جسين هيك
+
+473
+00:33:48,140 --> 00:33:56,520
+تخيل هي الـ client عنده socket هيها من ثلاث مداخل
+
+474
+00:33:56,520 --> 00:34:01,640
+على فرض هيك وهي
+
+475
+00:34:01,640 --> 00:34:08,800
+الـ server، الـ server هي الـ server socket أشبه
+
+476
+00:34:08,800 --> 00:34:16,030
+بالودن وجاعداش بستنى الاتصالأتجى الـ request قال
+
+477
+00:34:16,030 --> 00:34:23,130
+okay أنا بدي اتصال، عمل accept وروح
+
+478
+00:34:23,130 --> 00:34:27,410
+بنشقلي الـ socket هان بالشكل
+
+479
+00:34:27,410 --> 00:34:33,830
+هذا وبقول يوصل معايا هيك وهذه خلصنا من هيك انتهى
+
+480
+00:34:33,830 --> 00:34:37,850
+القمر، اتحررت قاعدة بتعمل lesson لأي income request
+
+481
+00:34:37,850 --> 00:34:43,100
+ممكن الـ client ثاني يعمل request فبروح إذا accept
+
+482
+00:34:43,100 --> 00:34:48,060
+بروح بنشيله كمان socket مناسب إليه، بروح بحطهم في
+
+483
+00:34:48,060 --> 00:34:53,360
+اتصال مع بعض من أجل نقل البيانات، تمام الـ socket
+
+484
+00:34:53,360 --> 00:34:56,560
+معناته الـ method dot accept، تمام، الآن أنا بدي أبني
+
+485
+00:34:56,560 --> 00:35:02,560
+input و output reading بالمثال اللي أنا جايبه، بدي
+
+486
+00:35:02,560 --> 00:35:05,440
+أؤكد على الشغل ثاني ممكن تقراه text وممكن تقراه
+
+487
+00:35:05,440 --> 00:35:10,760
+binary، احنا شوفنا مع الـ file شوفنا في الكتابة على
+
+488
+00:35:10,760 --> 00:35:13,940
+الملفات كان في عندنا buffered writer وفي عندنا print
+
+489
+00:35:13,940 --> 00:35:17,840
+writer وفي عندنا output stream لنص، الـ text كان
+
+490
+00:35:17,840 --> 00:35:20,540
+في المقابل في عندي data output stream للـ binary
+
+491
+00:35:21,930 --> 00:35:25,730
+للقراءة كان في عندي الـ buffered reader والسكانر
+
+492
+00:35:25,730 --> 00:35:30,590
+والـ file input stream للـ text، في المقابل كان في عندي
+
+493
+00:35:30,590 --> 00:35:34,270
+data input stream عشان يتعمل input لـ binary data
+
+494
+00:35:34,270 --> 00:35:39,890
+على الـ file نفس الكلام أنا كهان عامل إيش بساوي وجبت
+
+495
+00:35:39,890 --> 00:35:43,710
+المثال متعمد أو متعمدين هيك عشان نوضح لك إن كل
+
+496
+00:35:43,710 --> 00:35:48,230
+عملية قراءة هان هتكون عملية كتابة من الناحية
+
+497
+00:35:48,230 --> 00:35:54,750
+الثانية والعكس صحيح، عرفت buffered reader، الـ new buffered
+
+498
+00:35:54,750 --> 00:35:57,390
+reader، طب الـ new buffered reader بدها تنبني على
+
+499
+00:35:57,390 --> 00:36:00,430
+input stream، الـ input stream هي اللي عرفت input
+
+500
+00:36:00,430 --> 00:36:06,250
+stream وحددتله الـ source تبعتها الـ socket client
+
+501
+00:36:06,250 --> 00:36:10,770
+-socket.git input stream، يعني الآن صارت ال
+
+502
+00:36:10,770 --> 00:36:13,940
+buffered reader هدي له الـ chunk تمام؟ أنا بقدر
+
+503
+00:36:13,940 --> 00:36:18,080
+أكتب وأقرأ منها chunks، هتوصل الـ data لمين؟ لل
+
+504
+00:36:18,080 --> 00:36:22,060
+socket dot input stream اللي موجودة عندها اللي هو
+
+505
+00:36:22,060 --> 00:36:33,780
+بجيت الـ code هذا get
+
+506
+00:36:33,780 --> 00:36:38,700
+input stream تمام؟ الآن عرفت الـ data output stream
+
+507
+00:36:39,740 --> 00:36:40,240
+out to
+
+508
+00:37:10,220 --> 00:37:14,680
+وبعد هيك السيرفر يعني في المرحلة هانعمل الـ process
+
+509
+00:37:14,680 --> 00:37:21,240
+المفروض وبعد هيك بيروح أكتب على السكت عشان أرد
+
+510
+00:37:21,240 --> 00:37:24,200
+السير للـ client اللي موجود عندي تعالي بس الـ code
+
+511
+00:37:24,200 --> 00:37:26,440
+أصلًا حدا هيك أنا مجرد عرفت الـ input والـ output
+
+512
+00:37:26,440 --> 00:37:31,760
+إيش راح نسوينا بعد هيك اللي أنا عرفته هان buffered
+
+513
+00:37:31,760 --> 00:37:35,240
+reader، مظبوط الـ buffered reader
+
+514
+00:37:37,970 --> 00:37:40,950
+خدت الـ String وهي الـ buffer دي اللي هي in from
+
+515
+00:37:40,950 --> 00:37:45,830
+الـ client read line، طب ما احنا شفنا ممكن اعمل
+
+516
+00:37:45,830 --> 00:37:48,810
+while كمان لما كان في عندي multi line ممكن أنا
+
+517
+00:37:48,810 --> 00:37:52,850
+أقرأه، طبعا هان احنا إننا نبرسل بس one line، عملنا
+
+518
+00:37:52,850 --> 00:37:56,010
+process هيه، والـ process اللي أنا عامله هو بشكل
+
+519
+00:37:56,010 --> 00:37:59,830
+بسيط بس حولت الـ string هذا لـ capital letter تمام؟
+
+520
+00:37:59,830 --> 00:38:04,320
+جاهز بقدره اعمل send، الآن السيرفر بدأ يعمل send
+
+521
+00:38:04,320 --> 00:38:09,740
+لمين؟ للـ client output dot output client dot بما
+
+522
+00:38:09,740 --> 00:38:12,660
+إنه أنا عرفته write output stream، فروحت استخدمت ال
+
+523
+00:38:12,660 --> 00:38:16,300
+method اسمها write bytes وديته الـ response text
+
+524
+00:38:16,300 --> 00:38:20,980
+اللي موجود عندها، خلصنا و closed، المفروض هذا ال
+
+525
+00:38:20,980 --> 00:38:26,420
+application ينعمله run وينتظر income request، تعالى
+
+526
+00:38:26,420 --> 00:38:30,340
+نشوف عند مين؟ عند الـ client إيش بده يكون موجود؟ هي
+
+527
+00:38:30,340 --> 00:38:34,740
+نفس الكلام عند الـ client، بدأت عرفت مين؟ عرفت ال
+
+528
+00:38:34,740 --> 00:38:40,440
+socket وحددتلها الـ ID address تبعت الـ server وال
+
+529
+00:38:40,440 --> 00:38:44,700
+board اللي احنا بنعمل عليه listening في ال
+
+530
+00:38:44,700 --> 00:38:47,460
+application تبعنا لأن الـ server شغال وتذكر ال
+
+531
+00:38:47,460 --> 00:38:52,420
+structure تبعته بشكل كويس، وعرفت input و output
+
+532
+00:38:52,420 --> 00:38:55,920
+وعرفت input و output بناء على الـ socket اللي عندي
+
+533
+00:38:55,920 --> 00:38:59,840
+هنا بنفس الكلام الـ data output، يعني أنا بدي أكتب
+
+534
+00:38:59,840 --> 00:39:04,380
+للـ server، out to server بناء على data output ال
+
+535
+00:39:04,380 --> 00:39:09,580
+stream، و buffered reader عشان أنا بدي أقرأ من ال
+
+536
+00:39:09,580 --> 00:39:16,640
+server، هاي الـ sentence سمعته سلام from client، أول
+
+537
+00:39:16,640 --> 00:39:20,240
+خطوة الـ client يسويها في الـ connection راح بعت
+
+538
+00:39:21,250 --> 00:39:26,530
+output to server اللي هي هذه اللي هي على الـ output
+
+539
+00:39:26,530 --> 00:39:30,710
+stream تبعية الـ socket اللي موجودة عندها، أكتب ال
+
+540
+00:39:30,710 --> 00:39:37,050
+sentence، فرح بعت الـ sentence فمقابلها كان مباشرة
+
+541
+00:39:37,050 --> 00:39:46,980
+الـ server in from client dot read line هذه كانت
+
+542
+00:39:46,980 --> 00:39:49,740
+مقابل الـ statement هذه بالتمام في الـ code كنت
+
+543
+00:39:49,740 --> 00:39:54,300
+بحطها مثلًا في الـ string اسمه str، أخذنا الـ str
+
+544
+00:39:54,300 --> 00:40:02,600
+عملنا uppercase وردناها من out to client dot
+
+545
+00:40:02,600 --> 00:40:09,300
+right bytes، والـ response فمقابلها تمامًا كنت عمالي
+
+546
+00:40:09,300 --> 00:40:12,380
+أنا باخد الـ input from server اللي هو ال buffered
+
+547
+00:40:12,380 --> 00:40:18,070
+reader dot readLine، هيك الـ process بتكون ناجحة 100%
+
+548
+00:40:18,070 --> 00:40:24,650
+كل عملية قراءة بتكون سبقها بعملية كتابة من الطرف
+
+549
+00:40:24,650 --> 00:40:31,110
+الثاني والعكس صحيح، والعكس صحيح وبتظل العملية لأن
+
+550
+00:40:31,110 --> 00:40:33,390
+أنا بدأت أدخل على سبيل المثال في الـ chat لو بدأت
+
+551
+00:40:33,390 --> 00:40:36,970
+أعمل برنامج الـ chat، إيش اللي بدو يصير هدول
+
+552
+00:40:36,970 --> 00:40:42,630
+الجملتين بدهم ينحقوا في loop وعالـ client وعال
+
+553
+00:40:42,630 --> 00:40:45,450
+server برضه بيكونوا موجودات في loop عشان تظهر
+
+554
+00:40:45,450 --> 00:40:46,510
+العملية عشان تظهر العملية عشان تظهر العملية عشان
+
+555
+00:40:46,510 --> 00:40:50,210
+تظهر العملية عشان تظهر العملية عشان تظهر العملية
+
+556
+00:40:50,210 --> 00:40:50,530
+عشان تظهر العملية عشان تظهر العملية عشان تظهر
+
+557
+00:40:50,530 --> 00:40:50,930
+العملية عشان تظهر العملية عشان تظهر العملية عشان
+
+558
+00:40:50,930 --> 00:40:51,430
+تظهر العملية عشان تظهر العملية عشان تظهر العملية
+
+559
+00:40:51,430 --> 00:40:55,290
+عشان تظهر العملية عشان تظهر العملية عشان تظهر
+
+560
+00:40:55,290 --> 00:40:57,290
+العملية عشان تظهر العملية عشان تظهر العملية عشان 
+
+561
+00:40:57,290 --> 00:41:02,910
+تظهر العملية عشان
+
+562
+00:41:03,730 --> 00:41:06,790
+أفحص الـ buffer و حسب الـ بن كتب فيه أبدأ عملية
+
+563
+00:41:06,790 --> 00:41:10,330
+القراءة و لا أعمل كتابة يعني دائما أفحص الـ buffer
+
+564
+00:41:10,330 --> 00:41:15,330
+فاضي و لا مليان و أصير إيش إما أعمل عملية الكتابة
+
+565
+00:41:15,330 --> 00:41:18,550
+أو أعمل عملية القراءة بالـ if الـ switch statement
+
+566
+00:41:18,550 --> 00:41:22,570
+أو حسب بعد ما بخلص بعمل close طبعا الـ file ليش
+
+567
+00:41:22,570 --> 00:41:25,590
+هتعقيد طيب أنت مستخدمة واحدة that واحدة binary و
+
+568
+00:41:25,590 --> 00:41:32,430
+واحدة ياش الـ text واحدة binary و واحدة text بس مجرد
+
+569
+00:41:32,430 --> 00:41:34,510
+أن أقول لك أن احنا متعاملين فيها handmeth الـ handmeth
+
+570
+00:41:34,510 --> 00:41:43,870
+الفايل الأصلي في البرنامج يكون بالشكل البسيط هذا يعني
+
+571
+00:41:43,870 --> 00:41:50,150
+أنا أعرف فوق buffer reader و أعرف buffer writer من
+
+572
+00:41:50,150 --> 00:41:53,670
+أجل الكتابة مش هتفرج معاكي ولا حاجة و طبعا بالـ
+
+573
+00:41:53,670 --> 00:41:57,130
+buffer reader زي ما شوفنا مع الـ file بعرف string
+
+574
+00:41:57,130 --> 00:42:02,320
+line وبعمل while عشان أكون في عندي أكتر من سطر أو 
+
+575
+00:42:02,320 --> 00:42:04,660
+ممكن إذا بدأ أقرأ كلمة كلمة أو character character
+
+576
+00:42:04,660 --> 00:42:08,100
+بالـ method read الأمر متروك إليك تماما إيش تعمل
+
+577
+00:42:08,100 --> 00:42:12,440
+implementation كذلك لما أنا بدي أكتب بدي أكتب dot
+
+578
+00:42:12,440 --> 00:42:18,260
+write بيت write byte بدي أكتب النص مباشرة buffer
+
+579
+00:42:18,260 --> 00:42:22,810
+writer هي.write هيك الـ method اللي احنا أخذناها
+
+580
+00:42:22,810 --> 00:42:26,670
+وإن شئتِ تستخدمي print write مافيش عندك مشكلة كمان
+
+581
+00:42:26,670 --> 00:42:30,150
+الفكرة وين أنه خلاص هصير أنا أتعامل مثل وكأني 
+
+582
+00:42:30,150 --> 00:42:34,290
+بأتعامل مع مع ملف هصير أتعامل وكأني بأتعامل مع 
+
+583
+00:42:34,290 --> 00:42:39,670
+ملف بعد هيك ما بخلص و بنسكر الـ code اللي موجود عندنا
+
+584
+00:42:39,670 --> 00:42:44,070
+أيه الآن كذلك لو أنا بدي كتابتي وقراءتي كلها تكون
+
+585
+00:42:44,070 --> 00:42:49,370
+binary data هصير أعتمد على مين على الـ Data Input
+
+586
+00:42:49,370 --> 00:42:52,610
+Stream والـ Data Output Stream مثلًا أنا كنت بدي
+
+587
+00:42:52,610 --> 00:42:56,510
+أكتب Double أو أقرأ Double لأن هذه ميزات الـ Data
+
+588
+00:42:56,510 --> 00:42:59,650
+Input Stream والتي بصير أنا بكتب حسب الـ Data Type
+
+589
+00:42:59,650 --> 00:43:05,510
+اللي موجودة عندي طبعًا الـ .. ممكن .. احنا نحتاج ..
+
+590
+00:43:05,510 --> 00:43:08,810
+يمكن يحتاج Multithreading المفهوم أنه أنا بدي أصير
+
+591
+00:43:08,810 --> 00:43:13,890
+الكود السابق هذا لو كان في جملة الكتابة هذه كنت
+
+592
+00:43:13,890 --> 00:43:18,510
+أنا بأخذ من ملف كبير حجم مثلًا 5 ميغا معناتها هو مش
+
+593
+00:43:18,510 --> 00:43:22,830
+هيخلص من هان وينتقل لهدي إلى إيش طيب طب إجاني
+
+594
+00:43:22,830 --> 00:43:27,190
+request جديد الـ request هيدل واقف هاد في الـ server
+
+595
+00:43:27,190 --> 00:43:32,150
+عفوا هيدل واقف هان لإنه عماله قاعد يبقى يقرأ يعني
+
+596
+00:43:32,150 --> 00:43:34,670
+هو لازم يخلص هذا ويكمل إيش يرجع للـ while عشان
+
+597
+00:43:34,670 --> 00:43:39,290
+يعمل الـ you accept إيش حلها عشان يخلّي كل الـ
+
+598
+00:43:39,290 --> 00:43:43,070
+session يبدو يشتغلوا بدي أستخدم الـ multitrading
+
+599
+00:43:43,070 --> 00:43:46,130
+اللي هنبدأ فيها المحاضرة أو الدرس الجاية الموضوع
+
+600
+00:43:46,130 --> 00:43:48,700
+اللي جاية عشان أعمل multi-threading بحيث يكون في
+
+601
+00:43:48,700 --> 00:43:51,300
+عندي زي هيك الـ client worker بدي يعمل implement
+
+602
+00:43:51,300 --> 00:43:54,840
+لشغل اسمه runnable وهو أنا بدي أعرف في الـ client
+
+603
+00:43:54,840 --> 00:43:57,760
+أن في عندي أيه الـ thread و أخلي الـ thread يشتغل
+
+604
+00:43:57,760 --> 00:44:01,740
+هيك عشان أصلا أصلا أخلي كل session أو كل clients
+
+605
+00:44:01,740 --> 00:44:05,550
+اللي دي يجوا يشتغلوا أيشوار بعض يشتغلوا في نفس
+
+606
+00:44:05,550 --> 00:44:09,350
+الوجود إن شاء الله تعالى هي كانت أخلصت تقريبا من
+
+607
+00:44:09,350 --> 00:44:12,290
+كل الشغلات اللي بدنا إياها الشبكات بضل إن إن شاء
+
+608
+00:44:12,290 --> 00:44:14,930
+الله المحاضرة اللي جاية بنحاول نشتغل شغل عملي عشان
+
+609
+00:44:14,930 --> 00:44:18,070
+نورّجيكي بعض الشغلات المفصلية اللي لها علاقة
+
+610
+00:44:18,070 --> 00:44:21,470
+بالشبكات وكيف ممكن تتجوزيها إن شاء الله تعالى، في
+
+611
+00:44:21,470 --> 00:44:24,690
+أي سؤال يا بنات؟ الله يعطيكوا العافية
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/6bcNAHnIxoc_postprocess.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/6bcNAHnIxoc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..7aab34422d15c75cbb5674cdbea4ab5bbe49d79f
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/6bcNAHnIxoc_postprocess.srt
@@ -0,0 +1,2048 @@
+1
+00:00:21,240 --> 00:00:22,960
+بسم الله الرحمن الرحيم الصلاة والسلام علي رسول
+
+2
+00:00:22,960 --> 00:00:26,720
+الله اليوم ان شاء الله هنكمل في موضوع ال thread ..
+
+3
+00:00:26,720 --> 00:00:29,800
+ال multi-threading و هنحاول نجمل الكلام اللي احنا
+
+4
+00:00:29,800 --> 00:00:36,560
+قلناه المحاضرة الماضية قلت سابقا كل برامجنا بال
+
+5
+00:00:36,560 --> 00:00:39,780
+Java لحد اللحظة .. لحد المحاضرة الماضية كانت
+
+6
+00:00:39,780 --> 00:00:44,680
+بتشتغل على single process أو single task أو حتى لو
+
+7
+00:00:44,680 --> 00:00:48,540
+كان في عندي multi-task فكانت execution تبعهم بتنهي
+
+8
+00:00:48,540 --> 00:00:52,940
+بشكل sequentialمع إنه المعالجات عندها قدرة عالية
+
+9
+00:00:52,940 --> 00:00:56,760
+إنها تشغل بأكتر أو تشغل بشكل parallel واتفقنا إنه
+
+10
+00:00:56,760 --> 00:01:01,020
+في عندي أنا process-based multitasking وفي عندي
+
+11
+00:01:01,020 --> 00:01:04,180
+thread-based multitasking لـ process-based قلنا
+
+12
+00:01:04,180 --> 00:01:06,520
+شغل ال operating system إنه يشغل أكتر من
+
+13
+00:01:06,520 --> 00:01:10,520
+application مع بعض وقلنا لـ thread-based شغل ال
+
+14
+00:01:10,520 --> 00:01:13,440
+application الواحد إنه يشغل أكتر من task بشكل
+
+15
+00:01:13,440 --> 00:01:17,840
+متزامنوبعدين نتكلم عن الـ Multithreading بالجاوة
+
+16
+00:01:17,840 --> 00:01:21,440
+نقول ان ال thread بشكل عام يعني أنا الآن بشتغل في
+
+17
+00:01:21,440 --> 00:01:25,260
+ال application تبعي بدون عمل branching حسب عدد ال
+
+18
+00:01:25,260 --> 00:01:28,300
+branches اللي ممكن تكون عندي و بعد هيك شغل كله
+
+19
+00:01:28,300 --> 00:01:33,360
+يتجمع مرة تانية يعني أنا فعليا جزء ال parallel او
+
+20
+00:01:33,360 --> 00:01:36,360
+ال concurrent بيكون في جزء من البرنامج وهذا
+
+21
+00:01:36,360 --> 00:01:39,320
+التقسيمة بدها تكون حسب ما انا جديش فاهم البرنامج
+
+22
+00:01:39,320 --> 00:01:43,600
+تبعيجديش الـdependency أو الـindependence الـ
+
+23
+00:01:43,600 --> 00:01:46,380
+independent parts موجودة في ال application تبعي
+
+24
+00:01:46,380 --> 00:01:50,800
+عشان أقدر أدي كل part ل thread معين وقولنا بشكل
+
+25
+00:01:50,800 --> 00:01:53,880
+عام ال thread لما أنا أنشئه يلو مجموعة من ال
+
+26
+00:01:53,880 --> 00:01:56,700
+states أو ال thread حياته بتدخل مجموعة من ال
+
+27
+00:01:56,700 --> 00:02:00,480
+states new, runnable, blocked, waiting, time
+
+28
+00:02:00,480 --> 00:02:04,960
+waiting و terminatedالـ new أنا أنشأته، بعدين
+
+29
+00:02:04,960 --> 00:02:08,960
+بنتقل لمرحلة تانية اللي بيناعمله run، execution،
+
+30
+00:02:08,960 --> 00:02:11,140
+blocked أثناء ال execution، بده resource، لكن ال
+
+31
+00:02:11,140 --> 00:02:14,240
+resource ده محجوز، هيعمل wait، الآن waiting هو
+
+32
+00:02:14,240 --> 00:02:18,020
+جاعد بيستنى task أو بيستنى result من ال thread
+
+33
+00:02:18,020 --> 00:02:21,740
+تاني إنها تجهزت، terminated و time waiting، أنا
+
+34
+00:02:21,740 --> 00:02:24,960
+عامله sleep، يستنى فترة زمنية محددة، ثم يشتغل
+
+35
+00:02:24,960 --> 00:02:27,360
+عليها و ال estate الأخيرة اللي بيسميها terminated
+
+36
+00:02:27,360 --> 00:02:32,450
+لما بينتهيوكنت عشان أنشئ الـ thread بالـ Java و
+
+37
+00:02:32,450 --> 00:02:36,650
+بالـ code تبعي عندي حالتين إما بدي أعمل extend للـ
+
+38
+00:02:36,650 --> 00:02:40,450
+thread class يعني بدي أتورث خصائص من ال thread
+
+39
+00:02:40,450 --> 00:02:44,770
+class أو بدي أعمل implement للـ runable interface
+
+40
+00:02:44,770 --> 00:02:49,550
+طب، هل في أفضلية لاتنتين؟ هادي ولا هادي؟ مابتفرجش
+
+41
+00:02:49,550 --> 00:02:54,550
+كتير معايا بس بيحكمني في الاستخدام .. عفوا موضوع
+
+42
+00:02:54,550 --> 00:02:56,470
+ال inheritance اللي اتعلمناه في ال object oriented
+
+43
+00:02:57,390 --> 00:03:00,030
+أنا لما بكون في عندي class و عامل extend من super
+
+44
+00:03:00,030 --> 00:03:02,890
+class زي ال employee أو ال student أو ال vehicle
+
+45
+00:03:02,890 --> 00:03:06,230
+إلى آخره أنا ماقدرش أروح أقوله كمان مرة extend
+
+46
+00:03:06,230 --> 00:03:10,490
+threadsلكن بروح بقدر اقول له implement runnable
+
+47
+00:03:10,490 --> 00:03:14,230
+فالان حسب الشغل او الاتجاه اللي انا بدي اشتغل فيه
+
+48
+00:03:14,230 --> 00:03:17,290
+حسب وضع ال application او ال application اللي انا
+
+49
+00:03:17,290 --> 00:03:19,890
+اعمل ال application اللي انا بقى اشتغل فيه وقولنا
+
+50
+00:03:19,890 --> 00:03:23,330
+في كل الحالتين بدي اعمل override او بدي اعمل
+
+51
+00:03:23,330 --> 00:03:26,230
+implementation للميثود اللي اسمها run هذا ال
+
+52
+00:03:26,230 --> 00:03:29,750
+example بشكل سريع اللي احنا شوفناه extends thread
+
+53
+00:03:30,890 --> 00:03:35,070
+الـ run طبعاً تبهي ال data type تبعتها void يعني
+
+54
+00:03:35,070 --> 00:03:37,990
+مافي return data وهي ال execution تبعتها عشان اعمل
+
+55
+00:03:37,990 --> 00:03:43,090
+time waiting sleep هيها لو انا بدروح اعمل
+
+56
+00:03:43,090 --> 00:03:49,590
+implement لل runnable نفس ال code run و برضه void
+
+57
+00:03:49,590 --> 00:03:54,390
+و نفس ال code السابق بدون اي مشاكل في داخل ال main
+
+58
+00:03:54,390 --> 00:03:59,070
+application تبعي اللي من البدايةmy thread واقتي
+
+59
+00:03:59,070 --> 00:04:02,710
+واحد my thread و اديته الزمن و اديته اسم و حددته
+
+60
+00:04:02,710 --> 00:04:06,910
+priority my thread اتنين و اديته زمن و اديته اسم و
+
+61
+00:04:06,910 --> 00:04:11,430
+حددته priority thread تلاتة و هان ضروري ان تنتبه
+
+62
+00:04:11,430 --> 00:04:15,110
+ان انا رجعت لل super class thread بينما هان كنت
+
+63
+00:04:15,110 --> 00:04:19,090
+بتعامل مع ال my thread اللي انا عملتله extend و
+
+64
+00:04:19,090 --> 00:04:23,570
+العلاقة بينهم is A طيب و روحت في الآخرة ايش قلتله
+
+65
+00:04:23,570 --> 00:04:28,160
+هان ال new thread و اديتهobject mail الـ my
+
+66
+00:04:28,160 --> 00:04:34,020
+runnable اللي انا اشتغلت عليه تمام وقلنا start
+
+67
+00:04:34,020 --> 00:04:41,460
+بتستدعي ال run method في كل واحد منهم و بمجرد انها
+
+68
+00:04:41,460 --> 00:04:45,620
+تبدأ الشغل تنتقلاش على اللي بعدها مابتستناش تخلص
+
+69
+00:04:45,620 --> 00:04:49,160
+وبهيك صار في عندي انا multi-threading اشتغل في ال
+
+70
+00:04:49,160 --> 00:04:54,440
+application تبعي وقلنا كلام مهم جدا ان ماحدش بيضمن
+
+71
+00:04:54,440 --> 00:05:00,030
+كيف شكل ال outputليش؟ لأن كل هذا بيعتمد على ال CPU
+
+72
+00:05:00,030 --> 00:05:03,230
+ال CPU scheduler و dispatcher جداش في عنده task
+
+73
+00:05:03,230 --> 00:05:07,170
+جداش ال CPU busy جداش idol فبروح بصير يعطي أو يجسم
+
+74
+00:05:07,170 --> 00:05:12,730
+الأوقات اللي موجودة عندنا أهم وقلنا بعد هيك أو
+
+75
+00:05:12,730 --> 00:05:15,610
+انتقلنا في نهاية المحاضرة اتكلمنا على شغل يسميناها
+
+76
+00:05:15,610 --> 00:05:19,150
+ال synchronization أو ال look على ال resources
+
+77
+00:05:19,150 --> 00:05:22,810
+اللي موجودة في داخل ال application تبعي يعني لو
+
+78
+00:05:22,810 --> 00:05:30,470
+كان في عندي data fileملف بدي أقرأ منه أو بدي أكتب
+
+79
+00:05:30,470 --> 00:05:35,230
+عليه إذا أنا بتكلم قراءة أو كتابة عملية القراءة
+
+80
+00:05:35,230 --> 00:05:37,910
+مافيش فيها مشكلة مابتستدعيش إنه هقنع مالك لأنه
+
+81
+00:05:37,910 --> 00:05:41,310
+أكتر من user ممكن يقرأ من نفس الملف بدون مشكلة لكن
+
+82
+00:05:41,310 --> 00:05:44,830
+المشكلة بتصير واضحة متى عند الكتابة إذا أنا بدي
+
+83
+00:05:44,830 --> 00:05:48,810
+أكتب على الملف فلازم أنا أغلق الملف ال thread على
+
+84
+00:05:48,810 --> 00:05:53,390
+فرض إنه أنا فيه عندي T1و T2 و T3 دول الـ different
+
+85
+00:05:53,390 --> 00:05:56,370
+threads و بدهم يصلوا للملف هذا عشان يكتبوا عليه
+
+86
+00:05:56,370 --> 00:06:00,410
+طبعا أثناء ال execution فيه فرق زمني ما بينهم
+
+87
+00:06:00,410 --> 00:06:07,650
+مصبوط الآن T3 وصل لمرحلة
+
+88
+00:06:07,650 --> 00:06:14,490
+قراءة الملف جبلالان بدنا نعمل lock لل file ال file
+
+89
+00:06:14,490 --> 00:06:18,710
+هذا ممكن يكون ال realist ممكن يكون ال vector ممكن
+
+90
+00:06:18,710 --> 00:06:23,370
+يكون اي شغل تانية اي object تاني موجود عندى فانا
+
+91
+00:06:23,370 --> 00:06:28,910
+بدروح اعمله lock ال lock كان معناته اتنين هدول هذا
+
+92
+00:06:28,910 --> 00:06:36,670
+لسه ماوصلش هذا وصل هيدخل في مرحلة blocked مغلق مش
+
+93
+00:06:36,670 --> 00:06:41,390
+هيقدر يشتغل ليش لأن ال resource اللى بدهمشغول أو
+
+94
+00:06:41,390 --> 00:06:47,650
+محجوز من خلال T1 أو T3 خلص T3 وحده هيدا بيكون وصل
+
+95
+00:06:47,650 --> 00:06:55,050
+الان واحد منهم فمجرد هدي يعمل release واحد منهم
+
+96
+00:06:55,050 --> 00:06:58,050
+هيمسك ال resource هيعمل lock والتاني هيدخل في
+
+97
+00:06:58,050 --> 00:07:02,870
+مرحلة ال blocked عشان أنفذ عملية ال blocked هذه في
+
+98
+00:07:02,870 --> 00:07:06,510
+عندي تلت حالات إما بروح باتجاه ال synchronized
+
+99
+00:07:06,510 --> 00:07:10,610
+methodو بالـ Synchronized method أنا بده أروح
+
+100
+00:07:10,610 --> 00:07:13,650
+أستخدم الـ keyword الـ keyword الموجود عندي
+
+101
+00:07:13,650 --> 00:07:16,750
+Synchronized في الـ definition تبعت الميثود أنا
+
+102
+00:07:16,750 --> 00:07:20,030
+بدي أقرأ ملف أو بدي أكتب على ملف الميثود هذه بروح
+
+103
+00:07:20,030 --> 00:07:24,990
+بعرفها public Synchronized public Synchronized
+
+104
+00:07:24,990 --> 00:07:29,750
+لاحظوا الميثود هذه مش static public Synchronized
+
+105
+00:07:29,750 --> 00:07:32,910
+مفهوم كلمة Synchronized هي موضوع الـ look أنه لازم
+
+106
+00:07:32,910 --> 00:07:35,490
+يكون فيه تزامن في التعامل مع الميثود هذه أطبقوا
+
+107
+00:07:36,600 --> 00:07:39,780
+Synchronized مفهومها Synchronized method بمجرد أن
+
+108
+00:07:39,780 --> 00:07:46,340
+ال thread الأول يعمل call لل method هذه ال method
+
+109
+00:07:46,340 --> 00:07:51,500
+هذه بيعملها look للكود اللي جاي نتبهي معايا لهذا
+
+110
+00:07:51,500 --> 00:07:55,360
+الشغل الآن هذا الكلام مهم بدي أرجع معاكي للمثال
+
+111
+00:07:55,360 --> 00:07:58,200
+السابق و أخلي ال function هذه حاضرة في ذهنك الآن
+
+112
+00:07:58,200 --> 00:08:07,820
+لو أنا جيت كتابة getdata file أو get data from
+
+113
+00:08:07,820 --> 00:08:13,780
+file اللي هي ال method تبعتنا ال execution هو
+
+114
+00:08:13,780 --> 00:08:18,920
+sequential ولا؟ تمام يعني هيبدأ ينفذ هنا هييجي على
+
+115
+00:08:18,920 --> 00:08:22,640
+ال method وينتقل جوا ال method sequential لما يخلص
+
+116
+00:08:22,640 --> 00:08:27,120
+يكمل اللي بعدها، بصبت؟ طيب ما هو ال code هذا مشترك
+
+117
+00:08:27,120 --> 00:08:29,900
+بين T1 وT2 وT3
+
+118
+00:08:32,050 --> 00:08:37,990
+T1 أو T3 عفوا وصل جابلهم وصل لـ method هان بمجرد
+
+119
+00:08:37,990 --> 00:08:43,170
+عمل call لـ method الان شخص ساوية بيمنع أي thread
+
+120
+00:08:43,170 --> 00:08:46,990
+يكمل execution هذه مفهومها يكمل execution على
+
+121
+00:08:46,990 --> 00:08:51,090
+الكود اللي جاي لأن كله بيمر بنفس المرحلة فهذا من
+
+122
+00:08:51,090 --> 00:08:54,770
+هان من بداية ال calling لـ method هذه حتى نهايتها
+
+123
+00:08:54,770 --> 00:09:00,060
+ال function هذه إيش locked يعني كلالـ threads اللي
+
+124
+00:09:00,060 --> 00:09:03,060
+بيمشوا وراه جاعدين أو متأخرين عنه شوية في ال
+
+125
+00:09:03,060 --> 00:09:07,220
+execution لما يصل المرحلة هذه هيجفوا لحد ما ..
+
+126
+00:09:07,220 --> 00:09:12,720
+يصيروا blocked لحد ما هذا يعمل release وبالتالي
+
+127
+00:09:12,720 --> 00:09:17,380
+متى بيخلص؟ لما يعمل return لل value المطلوب عنده
+
+128
+00:09:17,380 --> 00:09:21,290
+لحد ما يخلص كل ال functionفيها ميزة كويسة إنها
+
+129
+00:09:21,290 --> 00:09:24,870
+بتحافظ على الشغل كله consistent من أول الـ
+
+130
+00:09:24,870 --> 00:09:27,250
+function لأخريتها أنا ضامن إنه مافيش حد بيعمل
+
+131
+00:09:27,250 --> 00:09:31,390
+interference على الشغل اللي عندي ك thread لكن بعضه
+
+132
+00:09:31,390 --> 00:09:35,830
+فيها عيب طب لربما السطر أو الجزئية اللي أنا بدي
+
+133
+00:09:35,830 --> 00:09:41,050
+أكتب فيها سطر واحد موجود هان أعمل
+
+134
+00:09:41,050 --> 00:09:44,010
+wait لحد ما تخلص ال function أو أحط ل threads
+
+135
+00:09:44,010 --> 00:09:47,250
+التانية لحد ما تخلص ال function كل الفترة الطويلة
+
+136
+00:09:47,250 --> 00:09:54,360
+عادي طب ماما بروحبعمل block على قدر الجزئية اللي
+
+137
+00:09:54,360 --> 00:09:58,040
+أنا بدي إياها وبهيك بوفر وجد على ال threads
+
+138
+00:09:58,040 --> 00:10:01,200
+التانين بيبدوا يعملوا execution في ال method لحد
+
+139
+00:10:01,200 --> 00:10:05,500
+ما يصلوا الجزئية المحددة ال specific بيجفوا وبهيك
+
+140
+00:10:05,500 --> 00:10:08,580
+بصير في عندي أفضلية أو أديت وجد أو جلالة وجد
+
+141
+00:10:08,580 --> 00:10:13,200
+الانتظار أو وجد لمن؟ لل threads التانين واستفدت
+
+142
+00:10:13,200 --> 00:10:17,200
+بشكل أكبر مين اللي بيقرر أروح باتجاه synchronized
+
+143
+00:10:17,200 --> 00:10:21,550
+method ولا synchronized block؟أنت كـ Programmer أو
+
+144
+00:10:21,550 --> 00:10:24,610
+System Analyst اللي هو بيحدد الفقرة وين أنا بدي
+
+145
+00:10:24,610 --> 00:10:29,470
+أضيفهم Synchronized Block هي جزء من الـ Function
+
+146
+00:10:29,470 --> 00:10:35,760
+مش بالضرورة يكون كل الـ Function Synchronizedطبعا
+
+147
+00:10:35,760 --> 00:10:38,580
+هذه الـ method أنا في داخل الـ method بعرف الـ
+
+148
+00:10:38,580 --> 00:10:42,560
+synchronize مثلًا مثل الـ try و بحدد له ال object
+
+149
+00:10:42,560 --> 00:10:45,820
+اللي المفروض ايش بدي اعمل عليه انا بدي اعمل عليه
+
+150
+00:10:45,820 --> 00:10:48,800
+blocked و كل ال code اللي بدي نعمل عليه blocked
+
+151
+00:10:48,800 --> 00:10:53,300
+يكون في داخل ال curly braces الخاصة بمين بال
+
+152
+00:10:53,300 --> 00:10:58,180
+synchronize تبعتنا يعني هذا ال code هيكحسب المثال
+
+153
+00:10:58,180 --> 00:11:02,580
+هذا هينعمله closed block يعني فعليا أي thread
+
+154
+00:11:02,580 --> 00:11:06,420
+هيدخل و ال code اللي جاب لهذا هينفذه لحد ما يصل
+
+155
+00:11:06,420 --> 00:11:11,260
+لمين لـ synchronized block و قولنا الحالة التالتة
+
+156
+00:11:11,260 --> 00:11:17,200
+اللي عندنا static synchronization ان اعرف static
+
+157
+00:11:17,200 --> 00:11:22,960
+method تمام؟ في ال class اللي عندى as synchronized
+
+158
+00:11:22,960 --> 00:11:27,490
+يعني حصي في تعريفها publicstatic-synchronized
+
+159
+00:11:27,490 --> 00:11:31,810
+public-synchronized static والـ data type تبعتها
+
+160
+00:11:31,810 --> 00:11:35,990
+صار في عندي four modifiers موجودين من ال method
+
+161
+00:11:35,990 --> 00:11:40,930
+الآن إذا أنا عرفت ال method static عرفتها
+
+162
+00:11:40,930 --> 00:11:47,590
+synchronized مفهومها بمجرد أي object بغض النظر هل
+
+163
+00:11:47,590 --> 00:11:51,770
+ال object هذا common مع ال threads ولا different
+
+164
+00:11:51,770 --> 00:11:55,430
+threads يشتغلوا عليه بمجرد ينعمل كل ال method هذه
+
+165
+00:11:56,650 --> 00:12:00,130
+كل الـ objects اللي معمولة على ال class كل ال
+
+166
+00:12:00,130 --> 00:12:03,510
+instances اللي مبنية على ال class بنعملها Blocked
+
+167
+00:12:03,510 --> 00:12:07,270
+ماحدش مابدأ يشتغل، خلصنا طب هذا و هذا two
+
+168
+00:12:07,270 --> 00:12:10,050
+different المفروض هدول التانين جايين من نفس ال
+
+169
+00:12:10,050 --> 00:12:16,330
+class هدول different classes الحل خلاص انت معرف ال
+
+170
+00:12:16,330 --> 00:12:19,590
+method اللي عندنا هنا Synchronize او Static
+
+171
+00:12:19,590 --> 00:12:23,630
+Synchronization Synchronize Static Method معناته
+
+172
+00:12:23,630 --> 00:12:28,860
+انت هتعمل لكطيب و بهك كنا نهينا موضوع المحاضرة
+
+173
+00:12:28,860 --> 00:12:34,640
+الماضية كلها يا كما الان اللي ضايل عنا شغلة او
+
+174
+00:12:34,640 --> 00:12:39,640
+تنتين مهمات جدا فى موضوع ال threads عشان السبت
+
+175
+00:12:39,640 --> 00:12:45,640
+نشتغل عمله ان شاء الله تعالى الان فى
+
+176
+00:12:45,640 --> 00:12:46,280
+ال code هذا
+
+177
+00:12:49,720 --> 00:12:55,320
+T1, T2, T3, T4 طب لو أنا بدي أكتر من هيك بدي كله
+
+178
+00:12:55,320 --> 00:12:59,380
+مكتوب بالشكل هذا بيبقى اللي عارف فيهم؟ هل منطق؟ لأ
+
+179
+00:12:59,380 --> 00:13:03,640
+طب بدي أحطهم جوا loop بنفع أحط الصدر هذا جوا loop
+
+180
+00:13:03,640 --> 00:13:09,020
+من خمس iterations؟
+
+181
+00:13:09,020 --> 00:13:14,200
+لأ لأن كل مرة بينشي object يجيب بنفس الإسم كل مرة
+
+182
+00:13:14,200 --> 00:13:17,780
+بينشي object يجيب بنفس الإسم وبالتالي مش منطقية
+
+183
+00:13:17,780 --> 00:13:21,140
+الشغل هيكفلما بدوا يتفكروا في الـ Multithreading
+
+184
+00:13:21,140 --> 00:13:29,180
+لك ممكن انا اشتغل على شغلة اسمها thread pool pool
+
+185
+00:13:29,180 --> 00:13:32,480
+اللي هي المسبح او البركة تمام؟ و لما اتكلم على
+
+186
+00:13:32,480 --> 00:13:34,940
+thread pool يعني انا بتكلم عندي على مجموعة من ال
+
+187
+00:13:34,940 --> 00:13:41,400
+threads انا بانشئها دفعة واحدة بانشئها دفعة واحدة
+
+188
+00:13:41,400 --> 00:13:46,460
+الان thread pool is an instance of executor
+
+189
+00:13:46,460 --> 00:13:51,960
+serviceوهذا ال class هو اللي هنعتمد عليه في إنشاء
+
+190
+00:13:51,960 --> 00:13:59,760
+ال threads لاحقا تمام ال executor services هذا
+
+191
+00:13:59,760 --> 00:14:05,700
+بنشئ ليه خمس أنواع مختلفة من ال threads الأول
+
+192
+00:14:05,700 --> 00:14:10,820
+single thread executor من خلال ال executors.new
+
+193
+00:14:10,820 --> 00:14:15,040
+single executor يعني بنشئ انا ايش؟ thread واحد فقط
+
+194
+00:14:17,770 --> 00:14:24,190
+Cached Thread Ball ايش مفهوم الـ Cache؟ ان يكون
+
+195
+00:14:24,190 --> 00:14:27,330
+فيه عندى شغلاء جاهزة، مظبوط؟ انه فيه اشي جاهز
+
+196
+00:14:27,330 --> 00:14:30,930
+للاستخدام، مايروحش ينشقلي ايام جديدة لما انا بروح
+
+197
+00:14:30,930 --> 00:14:35,630
+بقوله Cached Thread Ball ال scooter هذا هيروح
+
+198
+00:14:35,630 --> 00:14:39,730
+ينشقلي مجموعة من ال threads انا بحدد عددهم وليكن
+
+199
+00:14:39,730 --> 00:14:43,730
+خمسة على سبيل المثال الخمسة هدول اذا انا ما
+
+200
+00:14:43,730 --> 00:14:49,190
+استغلتهمتمام؟ ضمن فترة معينة اللي هي سبتين second
+
+201
+00:14:49,190 --> 00:14:54,890
+هيروحوا الخنسة على ال terminated state ايش يعني
+
+202
+00:14:54,890 --> 00:14:58,890
+هيسرلهم؟ هيعملهم kill، هيموتهم، يحذفهم بمعنى آخر
+
+203
+00:14:58,890 --> 00:15:03,550
+يعني ممكن أنا أروح أنشق cashed thread pool من عشرة
+
+204
+00:15:03,550 --> 00:15:09,350
+thread و أبدأ عنده في الشغل تبعي خلال أول سبتين
+
+205
+00:15:09,350 --> 00:15:14,850
+ثانية استغلت فقط منهم أربعةالست التانية حينعملهم
+
+206
+00:15:14,850 --> 00:15:22,870
+كل ميزة وعيب في نفس الوجد ميزة ان انا بحافظ على ال
+
+207
+00:15:22,870 --> 00:15:27,150
+CPU تبعي و وضع ال state نيحة بحيث انه مابستغلغش او
+
+208
+00:15:27,150 --> 00:15:33,750
+مابحجزش وجد او space في ال memory بدون فايدة هذه
+
+209
+00:15:33,750 --> 00:15:38,690
+الميزة العيب ان هذا بفرض عليا challenge انا ك
+
+210
+00:15:38,690 --> 00:15:44,830
+developer ان اعرف فقط thread على حسبحاجتي على حسب
+
+211
+00:15:44,830 --> 00:15:51,230
+حاجتي النوع التالت fixed thread pool ال fixed
+
+212
+00:15:51,230 --> 00:15:57,210
+thread pool انا بنشي عدد طبعا الان fixed على خلافي
+
+213
+00:15:57,210 --> 00:16:02,410
+cash بنشي عدد ثابت خمسة عشرة استغلت منهم تلاتة
+
+214
+00:16:02,410 --> 00:16:07,450
+الباقي بيبقى اللي موجود هكذا انت حاجزت CPU وTime و
+
+215
+00:16:07,450 --> 00:16:11,890
+memory space بدون usageوبالتالي في الـ Fixed
+
+216
+00:16:11,890 --> 00:16:16,730
+Thread Pool انا بحدد العدد اللي انا بديه عيبها ان
+
+217
+00:16:16,730 --> 00:16:21,590
+لو انا احتجت اكبر من العدد ماقدرش أسوي حاجة ولو
+
+218
+00:16:21,590 --> 00:16:26,970
+احتجت اقل بكون في عندي waste في ال time Schedule
+
+219
+00:16:26,970 --> 00:16:30,550
+Thread Pool Schedule يعني انا بدي ال threads هتتم
+
+220
+00:16:30,550 --> 00:16:37,710
+إنشاءها عند فترة زمنية محددة تبع الجدول محددSingle
+
+221
+00:16:37,710 --> 00:16:42,230
+Thread Scheduled Pool Thread واحد لكنه يكون
+
+222
+00:16:42,230 --> 00:16:45,450
+Scheduled هنا نتكلم عن مجموعة وهنا نتكلم عن one
+
+223
+00:16:45,450 --> 00:16:49,770
+thread تعالى نشوف بالمثال ايش اللى هيفرق عن الكود
+
+224
+00:16:49,770 --> 00:16:55,050
+السابق روحك
+
+225
+00:16:55,050 --> 00:17:01,670
+بالمثال اللى عندنا هنا ومثال بسيط Executer
+
+226
+00:17:01,670 --> 00:17:02,130
+Service
+
+227
+00:17:04,890 --> 00:17:07,910
+executors.new fixed thread pool يعني أنا روح
+
+228
+00:17:07,910 --> 00:17:14,190
+بالاتجاه النوع التالت fixed
+
+229
+00:17:14,190 --> 00:17:16,750
+thread pool معناته أنا بديش fixed number of
+
+230
+00:17:16,750 --> 00:17:21,410
+threads و هيكون هدول موجودين لل task اللي بقى أنا
+
+231
+00:17:21,410 --> 00:17:27,570
+بدي أشتغل عليها الآن ايش قلتله؟ جديش العدد؟ تلاتي
+
+232
+00:17:27,570 --> 00:17:29,470
+يعني أنا بس بدي ال pool تبعتي مكونة من three
+
+233
+00:17:29,470 --> 00:17:35,810
+threads4 الـ I من واحد لخمسة هاي صار في عندي loop
+
+234
+00:17:35,810 --> 00:17:44,330
+في داخل ال loop أخدت counter سميته count وعطيته
+
+235
+00:17:44,330 --> 00:17:47,770
+قيمة ال I ويعني واحد، اتنين، تلاتة، اربعة، خمسة كل
+
+236
+00:17:47,770 --> 00:17:52,510
+مرة هيتغير ووراها مباشرة ال S اللي هي ال executor
+
+237
+00:17:52,510 --> 00:18:00,010
+service هاي dot execute أيوة
+
+238
+00:18:00,590 --> 00:18:07,630
+Execute هذه بتعمل creation أو بتعمل .. بتدّي ال
+
+239
+00:18:07,630 --> 00:18:12,390
+task لل thread يعني بتنشي ال thread و بتدّي إيش ال
+
+240
+00:18:12,390 --> 00:18:18,170
+task قبعته طيب إيش ال new runnable هذه؟
+
+241
+00:18:18,170 --> 00:18:20,850
+هي ال interface اللي احنا شفناها قبل هيك سابقاً بس
+
+242
+00:18:20,850 --> 00:18:25,070
+الآن هذه anonymous في المثال السابق object name
+
+243
+00:18:25,070 --> 00:18:29,830
+ديناها اسملما انا روحت عملت الـ implement للـ
+
+244
+00:18:29,830 --> 00:18:33,990
+runnable تمام؟ ال class تبعي my runnable أخدت منه
+
+245
+00:18:33,990 --> 00:18:41,050
+object هنا thread new my runnable بإمكاني كنت
+
+246
+00:18:41,050 --> 00:18:48,370
+أستغنى عنها و مباشرة أقوله new runnable تمام؟
+
+247
+00:18:48,370 --> 00:18:51,990
+و من ثم أنا بروح على object جديد أتعامل معاه و
+
+248
+00:18:51,990 --> 00:18:57,820
+سمنا احنا anonymous object تمام؟الان صار فى عندي
+
+249
+00:18:57,820 --> 00:19:01,940
+anonymous runnable صار
+
+250
+00:19:01,940 --> 00:19:07,580
+فى عندي runnable object بدون اسم انا بطلت يهمني
+
+251
+00:19:07,580 --> 00:19:12,020
+اجددش عدد مجرد احق العدد هان وانشي اللى بدك ياه من
+
+252
+00:19:12,020 --> 00:19:17,330
+ال runnable طيب لحتى الان الكلام generalفي داخل
+
+253
+00:19:17,330 --> 00:19:19,610
+الـ code هي implementation للـ run method اللي
+
+254
+00:19:19,610 --> 00:19:22,530
+احنا شوفناها سابقا اللي هي عند ال start بتتم عليها
+
+255
+00:19:22,530 --> 00:19:26,530
+الشغل مباشرة وال execute هتوجه ال run hand مباشرة
+
+256
+00:19:26,530 --> 00:19:30,610
+في داخلها كنت بعمل جملة اقطباعة او باطبع في لوبة
+
+257
+00:19:30,610 --> 00:19:37,950
+بتعمل جملة اقطباعة فقط thread text ال count اللي
+
+258
+00:19:37,950 --> 00:19:41,810
+انا عرفته فوق writes كتب وقيمة ال value تبع ال J
+
+259
+00:19:41,810 --> 00:19:46,430
+اللي هي من واحد لعشرة ووراها بيعمل sleep بمقدار100
+
+260
+00:19:46,430 --> 00:19:53,290
+ملي ساكند تمام بس خلصت ال definition تبعت ال
+
+261
+00:19:53,290 --> 00:20:01,770
+execute حيطلع error ليش؟ ايه؟ لأ هو ال error لإنه
+
+262
+00:20:01,770 --> 00:20:06,610
+هذه هيك لازم تكون .. اه هي موجودة بس أنا مضيع ال
+
+263
+00:20:06,610 --> 00:20:12,710
+ghost في ghost اه في ghost لازم تكون هنا طيب لأ مش
+
+264
+00:20:12,710 --> 00:20:18,170
+هيطلع error لأ لأ هذا تبعت ال mainالـ four لأن
+
+265
+00:20:18,170 --> 00:20:21,010
+هناك جملة تانية و هم اللي ورا الـ four فهي الناس
+
+266
+00:20:21,010 --> 00:20:30,070
+اللي جوز اكتبهم الآن مش هيطلع error الـ ball اللي
+
+267
+00:20:30,070 --> 00:20:34,850
+أنا أنشأت ساعته كام thread؟ تلاتة ثم ال task اللي
+
+268
+00:20:34,850 --> 00:20:42,190
+عندي لخمسة ايش هيساوي التنين ال two task التانيات
+
+269
+00:20:42,190 --> 00:20:46,470
+اللي أنشأليهم ال executorتمام؟ يعني هو الآن اللوب
+
+270
+00:20:46,470 --> 00:20:51,870
+هتشتغل هتشتغل هتنفذ الخمس مرات في كل مرة كانت
+
+271
+00:20:51,870 --> 00:20:55,870
+بتروح تحط للرنبل في مين؟ في الـ ball حطت الأول
+
+272
+00:20:55,870 --> 00:20:59,510
+والتاني والتالت الآن صار ال ball full انت لأ بصبوط
+
+273
+00:20:59,510 --> 00:21:05,390
+ساعته تلاتة راحت كمان مرة عملت generate للرابع طب
+
+274
+00:21:05,390 --> 00:21:09,070
+مافيش الوسع نحط في ال ball بنحط في Q في الامتدار
+
+275
+00:21:09,070 --> 00:21:14,330
+مجرد أن أول واحد منهم يخلصبدخل الرابع وين؟ على الـ
+
+276
+00:21:14,330 --> 00:21:20,810
+ball والخامس وراه وهكذا هذه ميزة ال ball دائما انا
+
+277
+00:21:20,810 --> 00:21:25,290
+بحدد عدد معين طبعا ليش العدد هدا؟ ليش انا محتاج ال
+
+278
+00:21:25,290 --> 00:21:29,340
+ball؟ اولا لان انا ممكن احتاج عدد ال threadsأكتر
+
+279
+00:21:29,340 --> 00:21:33,480
+من أني أروح أعرفهم الـ Static Threads في داخل ال
+
+280
+00:21:33,480 --> 00:21:35,760
+application تبعي صار في عيني الـ General
+
+281
+00:21:35,760 --> 00:21:40,460
+Definition للـ Thread هذه واحد اتنين لازم أحافظ
+
+282
+00:21:40,460 --> 00:21:44,020
+على قدرة المعالج اللي موجود عندها و أشغل ضمن قدرته
+
+283
+00:21:44,020 --> 00:21:48,260
+مر عليك أي application بدون ما يسألك أو يكون محدد
+
+284
+00:21:48,260 --> 00:21:52,100
+ال minimum requirement سواء نزلتي office و لا
+
+285
+00:21:52,100 --> 00:21:56,130
+operating systemولا براوزر ولا أي حد ولا حتى IDE
+
+286
+00:21:56,130 --> 00:21:59,890
+للبرمجة كل system مش ممكن تكتبليك ال minimum
+
+287
+00:21:59,890 --> 00:22:04,390
+requirement لل system هذا ان يكون المعالج كذا ال
+
+288
+00:22:04,390 --> 00:22:08,130
+memory كذا و ال space كذا هذا نفس الكلام بدي
+
+289
+00:22:08,130 --> 00:22:11,810
+اقراعيه انا هان لما اشتغل في ال application بشكل
+
+290
+00:22:11,810 --> 00:22:16,710
+عام طيب هذا البرنامج او التوجه هذا توجه عام انت
+
+291
+00:22:16,710 --> 00:22:21,390
+قاعد يا دكتورة بتطبع لنا جملة طباعة هانو بس، إيش
+
+292
+00:22:21,390 --> 00:22:25,470
+أنا المفروض أساوي؟ تخيل إيه إنه الآن أنت عندك
+
+293
+00:22:25,470 --> 00:22:34,950
+array من 100 ألف element integer مليون
+
+294
+00:22:34,950 --> 00:22:41,630
+element، مش هخسر ولا حاجة أنا أكيد في
+
+295
+00:22:41,630 --> 00:22:47,250
+عندي array حجمها مليون element integer وبتدرح أجيب
+
+296
+00:22:47,250 --> 00:22:53,200
+ال average تبعتهاماذا أفعل؟ إذا كنت تعمل على خطوة
+
+297
+00:22:53,200 --> 00:22:57,220
+واحدة يعني أنك تقول له هتاخد وجهة طيب ممكن انا
+
+298
+00:22:57,220 --> 00:23:02,260
+أروح أجسمهم على خمس خطوات انا بدي أحطك في صورة كيف
+
+299
+00:23:02,260 --> 00:23:06,000
+ممكن انا بدي أشتغل هنا طبعا في البداية هي القرية
+
+300
+00:23:06,000 --> 00:23:12,080
+تبعتي ال integer x
+
+301
+00:23:12,080 --> 00:23:14,980
+new integer
+
+302
+00:23:18,160 --> 00:23:20,580
+بغض النظر عن الـ syntax وكيف بدي أعملها
+
+303
+00:23:20,580 --> 00:23:25,220
+initialization زي ما بدك تسميها صارت الـ array
+
+304
+00:23:25,220 --> 00:23:29,440
+عندي جزء من ال application ال array جزء من ال
+
+305
+00:23:29,440 --> 00:23:33,760
+application و أروحنا أحنا ال array جزء من ال
+
+306
+00:23:33,760 --> 00:23:38,860
+application في داخل ال run هنا أنا عامل حسابي بدي
+
+307
+00:23:38,860 --> 00:23:42,000
+أعدل ال application تبعي هنا ل five threads عشان
+
+308
+00:23:42,000 --> 00:23:46,200
+كلهم يشتغلوا إيش بتتوقعي ممكن أسوي أنا؟ بدي أكتب
+
+309
+00:23:46,200 --> 00:23:51,790
+codeبدأ أجسم حجم الـ R على كل thread يعني الأول
+
+310
+00:23:51,790 --> 00:23:56,310
+يعني بالذنب أعمل switch case بالمناسبة مصبوط أو
+
+311
+00:23:56,310 --> 00:23:59,130
+بالذنب دائما أعمل iterator عشان أو عفوا counter
+
+312
+00:23:59,130 --> 00:24:04,150
+عشان أعرف من وين بدي يبدأ لما تكون ال I equal واحد
+
+313
+00:24:04,150 --> 00:24:10,450
+بدي أبدأ من وين ال thread الأول بدي أبدأ من صفر اه
+
+314
+00:24:10,450 --> 00:24:13,490
+يعني هدول مليون او مائة ألف مليون يعني بتكلم على
+
+315
+00:24:13,490 --> 00:24:19,400
+مائتين ألف مصبوط نصيب كل واحد فيهم من واحدلـ
+
+316
+00:24:19,400 --> 00:24:26,420
+199999 من صفر لـ 199999 هذا نصيب ال thread الأول
+
+317
+00:24:26,420 --> 00:24:30,980
+التاني يدرس ال counter اللي يبدأ فيه لما يشتغل
+
+318
+00:24:30,980 --> 00:24:35,200
+معلوق هي نفس القرية الموجودة عند التنين تمام؟
+
+319
+00:24:35,200 --> 00:24:38,680
+والتالت والرابع والخامس معناته أنا بلزم نهار اما
+
+320
+00:24:38,680 --> 00:24:42,420
+اعمل F statement او switch يعني switch لل count لل
+
+321
+00:24:42,420 --> 00:24:47,770
+count عشان احددجوا كل case من أين .. على الأقل الـ
+
+322
+00:24:47,770 --> 00:24:51,710
+pointer تبعها من أين بده يبدأ وبعد ال switch case
+
+323
+00:24:51,710 --> 00:24:56,190
+هذه ببدأ أروح أقوله أعمل summation هيك بده يبدأ
+
+324
+00:24:56,190 --> 00:25:01,690
+البرنامج تبعي يعني هيك، حرج أقوله مثلا switch ال
+
+325
+00:25:01,690 --> 00:25:05,630
+count case
+
+326
+00:25:05,630 --> 00:25:15,410
+1 ال index يساوي 0 ال index يساوي 0 وهي breakخلصنا
+
+327
+00:25:15,410 --> 00:25:24,930
+لو كانت ال case 2 ال index يساوي 200000 مصبوط و
+
+328
+00:25:24,930 --> 00:25:28,110
+التالتة و لما في الآخر بخلص هروح أقول له ال sum
+
+329
+00:25:28,110 --> 00:25:33,250
+equals 0 for عمّال iteration الآن من أين بدأت
+
+330
+00:25:33,250 --> 00:25:39,670
+تبدأي؟ من عند ال index ال integer I equal ال index
+
+331
+00:25:39,670 --> 00:25:41,170
+إلى
+
+332
+00:25:42,740 --> 00:25:44,940
+الـ maximum value اللي هتضيف عليهم الـ 200 ألف
+
+333
+00:25:44,940 --> 00:25:51,260
+التانيات نصيبه لحد آخر واحد ال sum plus ال S plus
+
+334
+00:25:51,260 --> 00:25:57,240
+equal ال array اللي هي X سميناها God of I وبعد هيك
+
+335
+00:25:57,240 --> 00:25:58,560
+بتروح ال A بتحسبيه لل average
+
+336
+00:26:02,250 --> 00:26:05,930
+لأ لأ for loop واحدة ليش تكتب اكتر من for loop انت
+
+337
+00:26:05,930 --> 00:26:10,470
+ال case بس عشان ياخد مين ياخد ال index و الآن بعد
+
+338
+00:26:10,470 --> 00:26:14,030
+هيك يبدأ كل loop بتبدأ من وين بناء على قيمة ال
+
+339
+00:26:14,030 --> 00:26:17,230
+index انت بحاجة ل code واحد لمرة واحدة هذا الكلام
+
+340
+00:26:17,230 --> 00:26:20,030
+انت اللي لازم تبدأ تفكر فيه لأنه حسب طبيعة ال
+
+341
+00:26:20,030 --> 00:26:23,890
+application هي اللي بتفرض عليكي مثلا انا في عندي
+
+342
+00:26:23,890 --> 00:26:28,890
+والله عشر ملفات أحجامهم مختلفة وكل مرة بدأ اقرأ
+
+343
+00:26:28,890 --> 00:26:32,950
+ملف مختلف تمام؟طب انا اخلهم ال thread واحد اللي
+
+344
+00:26:32,950 --> 00:26:35,470
+يقرأهم ولا اعمل عشرة thread كلهم يوم و كل واحد
+
+345
+00:26:35,470 --> 00:26:39,910
+يقرأ ملف عشرة thread ممكن ماصيرش بحاجة لأ ان اعمل
+
+346
+00:26:39,910 --> 00:26:44,130
+loop تمام؟ بس اعيد ضبط تسمية ال .. او ممكن اعمل ال
+
+347
+00:26:44,130 --> 00:26:48,870
+loop نفسها و اعيد ضبط اسم الملف و اضيف عليه الرقم
+
+348
+00:26:48,870 --> 00:26:52,670
+بس تبع ال index عشان اظل ماشية فانت كيف بدي تكون
+
+349
+00:26:52,670 --> 00:26:55,130
+البرنامج غير الصورة التقليدية او البسيطة اللي احنا
+
+350
+00:26:55,130 --> 00:26:59,560
+بنحن نوصلك الفكرة فيها؟هتكون الأمور تمام طيب نرجع
+
+351
+00:26:59,560 --> 00:27:03,320
+لمثالنا هذا عشان نكمل في مثالنا هذا ايش اللي
+
+352
+00:27:03,320 --> 00:27:10,760
+هيقبع؟ هيكتب ل thread ال count مثلا واحد write
+
+353
+00:27:10,760 --> 00:27:16,660
+واحد الان مش ضروري مباشرة اكتب ل thread واحد write
+
+354
+00:27:16,660 --> 00:27:22,810
+اتنين ويمكن يكتبها ممكنلكن بعدها هتلاقي thread 2
+
+355
+00:27:22,810 --> 00:27:28,230
+write 1 thread 3 write 1 thread 1 write 3 thread 2
+
+356
+00:27:28,230 --> 00:27:34,610
+write 4 write 5 و هكذا لكن اللي هتشوفيهم هان واحد
+
+357
+00:27:34,610 --> 00:27:40,490
+و اتنين و تلاتة فقط لمتى لحد ما تخلص ال loop هذه
+
+358
+00:27:40,490 --> 00:27:47,660
+بيكون واحد من ال threads هتخلص بتبدأ تشوف ميمأربعة
+
+359
+00:27:47,660 --> 00:27:52,800
+لأنه بمجرد أنه دخلهان حاول يعمل execute مالجهش
+
+360
+00:27:52,800 --> 00:27:56,180
+space في ال ball فاشرح سوا عمل pause ال counter
+
+361
+00:27:56,180 --> 00:28:01,640
+زاد فعمل و جفت pause وبالتالي مش حاجة يقدر أكمل أو
+
+362
+00:28:01,640 --> 00:28:04,380
+حطهم في ال queue فأربعة أو خمسة هتشوفيهم اتباعا
+
+363
+00:28:04,380 --> 00:28:09,060
+لكن بعد ما حد يخلص من هدول التلاتة اللي في الأول
+
+364
+00:28:09,060 --> 00:28:14,560
+الآن هذا الكلام هو
+
+365
+00:28:15,820 --> 00:28:20,480
+زبدة لـ threads تمام؟ و لازم احنا نحاول نفهمه بشكل
+
+366
+00:28:20,480 --> 00:28:25,720
+واضح في عيوب الآن العيب الأول .. العيب الأول في
+
+367
+00:28:25,720 --> 00:28:29,360
+حالة زي هذه أنا مافيش عند return data عشان اقدر
+
+368
+00:28:29,360 --> 00:28:33,680
+اخد القيمة اللي حسبتها وهذا بتدفعني ان اروح اعرف
+
+369
+00:28:33,680 --> 00:28:37,960
+global variable او اصير اخد ال value و احطه في ال
+
+370
+00:28:37,960 --> 00:28:39,700
+global variable طب احنا عارفين ان ال global
+
+371
+00:28:39,700 --> 00:28:43,340
+variable عليها مشاكل دايما و لا يحب تستخدامها
+
+372
+00:28:44,740 --> 00:28:51,140
+إتنين، لو صار في عندي أي مشكلة في داخل الـ run و
+
+373
+00:28:51,140 --> 00:28:55,200
+أنا مش عامل ا try و catch، مش هقدر أشوف .. مش هكمل
+
+374
+00:28:55,200 --> 00:29:01,240
+و مش هعرف أي thread اللي واجف، عشان هيك، راحوا
+
+375
+00:29:01,240 --> 00:29:05,680
+باتجاه interface مختلف تماما عن الـ runnableراحوا
+
+376
+00:29:05,680 --> 00:29:09,100
+باتجاه interface مختلف تماما عن الـ runnable حقق
+
+377
+00:29:09,100 --> 00:29:12,960
+فيه المستن أو عالجوا فيه اللعبين اللي قلنا عليهم
+
+378
+00:29:12,960 --> 00:29:23,160
+ال return data و ال exception handling الآن الشغل
+
+379
+00:29:23,160 --> 00:29:28,440
+السابق اللي هو في المثال هذا تقريبا نفسه مع فارق
+
+380
+00:29:28,440 --> 00:29:36,830
+بسيط جدا انه الآن هذا بيصير callableوالـ method
+
+381
+00:29:36,830 --> 00:29:41,770
+اسمها call بدل run بدل execute هتكون في عندي
+
+382
+00:29:41,770 --> 00:29:47,150
+submit وهتكون في عندي return data من نوع future
+
+383
+00:29:47,150 --> 00:29:50,710
+حلقة
+
+384
+00:29:50,710 --> 00:29:55,030
+نتكلم في التفاصيل يعني الآن ال code السابق هينضاف
+
+385
+00:29:55,030 --> 00:29:59,210
+عليه شغلات بسيطة تحقق أو تعالج العيبين اللي حاكينا
+
+386
+00:29:59,210 --> 00:30:03,370
+عليهم الأولى أن ال callable interface هو عبارة أو
+
+387
+00:30:03,370 --> 00:30:08,090
+استخدم genericعشان يعمل return ل data type ايش
+
+388
+00:30:08,090 --> 00:30:12,070
+generic؟ عام يعني بيظبط مع ال integer و بيظبط مع
+
+389
+00:30:12,070 --> 00:30:14,650
+ال string و بيظبط مع ال employee student .. ال
+
+390
+00:30:14,650 --> 00:30:17,110
+employee object و مع ال student object .. مع اي
+
+391
+00:30:17,110 --> 00:30:22,830
+حاجة ال executor هتنفذلي .. يوفرطلي مجموعة او
+
+392
+00:30:22,830 --> 00:30:27,810
+method عشان تنفذ ال callable اللي اسمها submit
+
+393
+00:30:27,810 --> 00:30:32,850
+هنشوفها في ال code كمان شوية في حين سابقا مع ال
+
+394
+00:30:32,850 --> 00:30:35,750
+runnable اسمها execute
+
+395
+00:30:38,360 --> 00:30:45,300
+one طيب الـ callable بعمل return ل object من نوع
+
+396
+00:30:45,300 --> 00:30:50,120
+future object من نوع future أول مرة نسمع عن data
+
+397
+00:30:50,120 --> 00:30:53,820
+type اسمها future صح؟ او ال future هذا هي عبارة عن
+
+398
+00:30:53,820 --> 00:30:57,800
+container بتحط فيه أي data type عشان هي اسمها
+
+399
+00:30:57,800 --> 00:31:01,560
+generic وحنشوف زي ما شوفنا مع ال array list أو مع
+
+400
+00:31:01,560 --> 00:31:04,780
+ال collections ايش كانت ميزة ال collections انها
+
+401
+00:31:04,780 --> 00:31:12,210
+generic بتاخد أيdata types هو كانت object غلط
+
+402
+00:31:12,210 --> 00:31:16,310
+تاخدش اللي غير reference data type ايوة ما بتاخد
+
+403
+00:31:16,310 --> 00:31:20,130
+ايوة بتاخد ال rubber class تبع ال primitive data
+
+404
+00:31:20,130 --> 00:31:23,750
+تعالى نشوف ال code ماضلش فيه كلام نظر كتير اه اذا
+
+405
+00:31:23,750 --> 00:31:27,230
+انا بدى ال value اللى موجودة او اللى تم تخزينها فى
+
+406
+00:31:27,230 --> 00:31:33,050
+ال future فى عندى method اسمها get و بترجع بال
+
+407
+00:31:33,050 --> 00:31:37,960
+data typeاللي تم إنشاء الـ future عليها تعالى نشوف
+
+408
+00:31:37,960 --> 00:31:44,360
+ال code البسيط هذا انسيلي ال future في الأول
+
+409
+00:31:44,360 --> 00:31:48,300
+executor dot new single thread executor نفس ال
+
+410
+00:31:48,300 --> 00:31:50,660
+code اللي احنا شوفناه سابقا بس كان مع thread pool
+
+411
+00:31:50,660 --> 00:31:57,380
+مظبوط من تلاتة الآن ايش نوعها future و بتعمل
+
+412
+00:31:57,380 --> 00:32:02,280
+rubbery class لل integer واسمه F dot
+
+413
+00:32:04,270 --> 00:32:07,570
+كمل الـ definition هذا dot submit يعني هذا كل ياته
+
+414
+00:32:07,570 --> 00:32:12,730
+ال code هذا اللي هان هو عبارة لحد اللي هان هيك في
+
+415
+00:32:12,730 --> 00:32:19,890
+تعريف ال future اللي عندي فوق الآن احنا قلنا سابقا
+
+416
+00:32:19,890 --> 00:32:27,590
+execute dot execute و
+
+417
+00:32:27,590 --> 00:32:32,230
+كنت بدّله new runnable مصبوط؟
+
+418
+00:32:33,200 --> 00:32:36,900
+الان انا روح تدخل الـ new callable و الـ callable
+
+419
+00:32:36,900 --> 00:32:39,560
+بده data type تتوافق مع ال future اللي انا بده اخد
+
+420
+00:32:39,560 --> 00:32:44,620
+منه ال data طيب ال callable عمل override او جال
+
+421
+00:32:44,620 --> 00:32:48,140
+يعمل override ل ال method اللي اسمها call و لازم
+
+422
+00:32:48,140 --> 00:32:51,620
+تتوافق مع نفس ال data type تبعت ال callable اللي
+
+423
+00:32:51,620 --> 00:32:55,470
+بتوافق مع ال data type الخاصةلأن في الآخر الـ
+
+424
+00:32:55,470 --> 00:32:58,550
+callable هي اللي هتعمل return لل data هيسلمها الـ
+
+425
+00:32:58,550 --> 00:33:01,770
+callable ويمررها لمين؟ لل future وانت بدك تاخد ال
+
+426
+00:33:01,770 --> 00:33:09,070
+result من ال future الآن في داخلها فقط أنا عملت
+
+427
+00:33:09,070 --> 00:33:13,830
+هنا مثال بسيط جدا بدي أعمل return ل 115 لي 23 ضرب
+
+428
+00:33:13,830 --> 00:33:20,720
+5و لا تنسى انها حدثت ان لدي hand صارت تعمل throw
+
+429
+00:33:20,720 --> 00:33:23,800
+لـ exception يعني لو حدث اي exception هنا في داخل
+
+430
+00:33:23,800 --> 00:33:27,560
+ال call بقى أشوفه بينما في ال run ماكنتش مقدر أسوي
+
+431
+00:33:27,560 --> 00:33:34,820
+هيك شغل تمام خلصنا هذا على one thread لو انا بدي
+
+432
+00:33:34,820 --> 00:33:38,960
+أعمل pool نفس الكلام مافيش مشكلة عندي هتعمل loop
+
+433
+00:33:38,960 --> 00:33:44,660
+وكل واحدة هترجع ب data type بد ال result الآن هاي
+
+434
+00:33:44,660 --> 00:33:49,140
+ال resultمش احنا اتفقنا ان ال result اللي هترجع
+
+435
+00:33:49,140 --> 00:33:55,320
+فيها ال call method هتتخزن وين؟ في ال future هي f
+
+436
+00:33:55,320 --> 00:34:00,960
+.get بترجعلي بال data type اللي تم تخزينها وين؟ في
+
+437
+00:34:00,960 --> 00:34:07,300
+داخل ال future الآن ليش حطيت integer أنا هنا؟ عادي
+
+438
+00:34:07,300 --> 00:34:11,300
+لأن هذا rubber class لهذه وفيها auto boxing و
+
+439
+00:34:11,300 --> 00:34:18,550
+unboxing، مظبوط؟ مية لميةطيب على مثال ال array ده
+
+440
+00:34:18,550 --> 00:34:22,050
+ايش المفروض ان انا اساوي لو انا بدي احسب عندي
+
+441
+00:34:22,050 --> 00:34:26,110
+array من مليون element و بدي اساوي ايش بدي اروح
+
+442
+00:34:26,110 --> 00:34:29,430
+اساوي هان؟ في ال call في داخل ال call بدي اعمل ليه
+
+443
+00:34:29,430 --> 00:34:33,590
+switch case عشان اجسم كمان و يحسب و اروح اعمل
+
+444
+00:34:33,590 --> 00:34:37,570
+return لمين؟ لل sum او لل average مش قضية كتير لل
+
+445
+00:34:37,570 --> 00:34:40,370
+sum او لل average هيعمل return و هيروح يضيفلي
+
+446
+00:34:40,370 --> 00:34:43,680
+اليوم في مين؟في ال future بس ال future فيها single
+
+447
+00:34:43,680 --> 00:34:46,400
+value هذا الآن معناته ال future هذا بيصير عبارة عن
+
+448
+00:34:46,400 --> 00:34:52,980
+ال ray بيصير عبارة عن ال ray أو ال ray list مصبوط؟
+
+449
+00:34:52,980 --> 00:34:56,560
+لأن كمان مرة انت تتخيل ان هان عامل احنا ايش هان؟
+
+450
+00:34:56,560 --> 00:35:01,780
+new single thread executor طب لأ أنا مابديش single
+
+451
+00:35:01,780 --> 00:35:06,750
+thread executor بيدوروح اقوله؟الـ New Fixed Thread
+
+452
+00:35:06,750 --> 00:35:11,770
+Pool بديش واحد بدي مجموعة انا خمسة عشان اجسمهم طب
+
+453
+00:35:11,770 --> 00:35:18,190
+ما هدول الخمسة New
+
+454
+00:35:18,190 --> 00:35:25,790
+Fixed Thread Pool خمسة
+
+455
+00:35:25,790 --> 00:35:28,890
+بدي
+
+456
+00:35:28,890 --> 00:35:34,010
+اعمل counter عشان الـ Submit تبعت عندي هنا صح؟ و
+
+457
+00:35:34,010 --> 00:35:37,960
+بدي اكملاللي انا بدي اجسم طب ما هي ال future هذي
+
+458
+00:35:37,960 --> 00:35:41,640
+بدنا معاهده في عندي five threads بدهم يشتغلوا كل
+
+459
+00:35:41,640 --> 00:35:47,640
+واحد له future فالحل اني اعمل array of futures او
+
+460
+00:35:47,640 --> 00:35:53,100
+array list of future و بعد هيك انا بروح باخداش ال
+
+461
+00:35:53,100 --> 00:35:56,100
+value من ال array list او من ال array تبعتي لكن في
+
+462
+00:35:56,100 --> 00:36:00,820
+شغل مهم جدا هنا مش ضروري ال array .. حفظك ال
+
+463
+00:36:00,820 --> 00:36:05,650
+thread الأوليخلص قبل ولا لا؟ اللي بيخلص أول هو
+
+464
+00:36:05,650 --> 00:36:09,010
+اللي بيضيف على ال future أو على ال array list
+
+465
+00:36:09,010 --> 00:36:11,810
+بتاعة ال future يعني ال index الأولى في ال array
+
+466
+00:36:11,810 --> 00:36:16,650
+لأول واحد بيخلص التاني على التاني و لا التالت و
+
+467
+00:36:16,650 --> 00:36:20,870
+هكذا، مصبوط؟ وبالتالي مافيش ضامن إيش الترتيب، بس
+
+468
+00:36:20,870 --> 00:36:24,390
+الشغل الوحيد اللي أنا بضمنها أن ال value اللي في
+
+469
+00:36:24,390 --> 00:36:28,380
+ال futureإذا كنت بتتكلم على average، الـ average
+
+470
+00:36:28,380 --> 00:36:31,600
+تبع الـ average value تاع ال future هي ال average
+
+471
+00:36:31,600 --> 00:36:35,420
+للarray كلها، وإذا كنت بتتكلم على ال sum، ال sum
+
+472
+00:36:35,420 --> 00:36:38,620
+لل values اللي موجودة في ال future بتمثل المجموع
+
+473
+00:36:38,620 --> 00:36:41,480
+تبع ال array كلها، ومن ثم أنا بدأ أكمل حسبتي
+
+474
+00:36:41,480 --> 00:36:44,760
+للآخر،
+
+475
+00:36:44,760 --> 00:36:50,940
+حتى هذا مثال هيني أنا بأجمع نفس المثال السابق، بس
+
+476
+00:36:50,940 --> 00:36:55,470
+أنا كنت بدون ال code هذاروحت جامعت و عملت return
+
+477
+00:36:55,470 --> 00:36:59,270
+للجامع فاتخزن وين؟ في ال future اللي موجود عندى
+
+478
+00:36:59,270 --> 00:37:02,510
+ليش انا هذا الكلام؟ عشان اوصلك لنفس المرحلة هذه
+
+479
+00:37:02,510 --> 00:37:08,010
+اللي انا عملت فيها ال loop هيها executor service
+
+480
+00:37:08,010 --> 00:37:14,470
+انا اجيت هنا executor service a new single بس مديش
+
+481
+00:37:14,470 --> 00:37:21,770
+a new single هنا a new fixed thread
+
+482
+00:37:21,770 --> 00:37:30,720
+boardالـ future هذا هيكون عبارة عن الـ realist من
+
+483
+00:37:30,720 --> 00:37:36,660
+ال future مصدورة او لا؟ و اصلا انا بدي اتعامل مع
+
+484
+00:37:36,660 --> 00:37:39,620
+ال element او مع العناصر اللي موجودة عندي هنا في
+
+485
+00:37:39,620 --> 00:37:44,020
+داخل ال array وهذا كل اللي عندنا في موضوع ال
+
+486
+00:37:44,020 --> 00:37:46,740
+threads يعني أو بين جسين هذه النقاط الأساسية
+
+487
+00:37:46,740 --> 00:37:50,790
+المهمة في موضوع ال threadsيوم السبت ان شاء الله
+
+488
+00:37:50,790 --> 00:37:53,750
+تبارك وتعالى .. ان شاء الله تكفينا الساعة ونحاول
+
+489
+00:37:53,750 --> 00:38:02,570
+نطبق كل الكلام ده إيش؟ بشكل عامل، نعم مرة
+
+490
+00:38:02,570 --> 00:38:06,410
+تانية، انشأتي threads أكتر من؟ أكتر من 100%
+
+491
+00:38:12,160 --> 00:38:17,740
+A K لأ لأ ما بديش هيك تخلطي تخلطي انه كل core
+
+492
+00:38:17,740 --> 00:38:23,540
+هياخد thread لأ ال thread هي هتكون ال process لل
+
+493
+00:38:23,540 --> 00:38:29,180
+core الواحد يعني انت في الآخر ال CPU عندك
+
+494
+00:38:29,180 --> 00:38:35,020
+different cores مظبوط حتى ال core الواحد ideal مثل
+
+495
+00:38:35,020 --> 00:38:38,980
+الأن مين اللي بتولّى تشغيل ال cores ال operating
+
+496
+00:38:38,980 --> 00:38:43,250
+systemانت كل اللي بتسويه في ال application بتقوليه
+
+497
+00:38:43,250 --> 00:38:46,210
+لل operating system انه انا في عندى different task
+
+498
+00:38:46,210 --> 00:38:49,090
+بدي أنفذها ال operating system اللي بياخدها و
+
+499
+00:38:49,090 --> 00:38:52,430
+بوزعها خلص ال core الأول هو اللي بيعطي ال core
+
+500
+00:38:52,430 --> 00:38:55,250
+التاني و بيعطي ال core التالت والرابع طب كل ال
+
+501
+00:38:55,250 --> 00:38:58,880
+cores busyالـ task تبعتك بتخش في الـ queue تبعت ال
+
+502
+00:38:58,880 --> 00:39:02,500
+operating system و بنفذها تباع لما بيجيها الدور
+
+503
+00:39:02,500 --> 00:39:07,120
+أما مالكيش دخل انت ممكن تقل ب 100 على single core
+
+504
+00:39:07,120 --> 00:39:10,960
+100 thread على single core احنا هي هي بالمثال هذا
+
+505
+00:39:10,960 --> 00:39:18,180
+إيش عملنا؟ عملت three threads بصبت و روحت قلتله
+
+506
+00:39:18,180 --> 00:39:23,880
+أنا في عندي خمسة taskوين الـ 1010 الأخرانيات دخلوا
+
+507
+00:39:23,880 --> 00:39:27,380
+في ال weight أو في ال Q لحد ما يخلص ال pool يصير
+
+508
+00:39:27,380 --> 00:39:29,700
+فيها متسع و نفس الكلام بيصير عندك على ال operating
+
+509
+00:39:29,700 --> 00:39:33,500
+system بس مش شغلك انت اللي تعملي له management لأن
+
+510
+00:39:33,500 --> 00:39:35,860
+ال operating system هو اللي بتدور عندك فانت ما
+
+511
+00:39:35,860 --> 00:39:40,140
+تقارن أو ما تربط بعدد ال thread بعدد ال cores اللي
+
+512
+00:39:40,140 --> 00:39:43,160
+موجودة عندك على المعالج أي سؤال تاني بنات؟
+
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/KTeCDkVljn0_raw.json b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/KTeCDkVljn0_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..3be07a9c49e8679ec58a192c56c67ec22cd5376a
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/KTeCDkVljn0_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 4491, "start": 21.21, "end": 44.91, "text": "بسم الله والحمد لله والصلاة والسلام على رسول الله طيب اليوم ان شاء الله بنات هنكمل في موضوع ال graphical user interface و هنكمل شغلنا هو نعمل review بسيطة لل layout و ننتقل ل three components جداد و هم هيكونوا اول components من ال graphical user interface اللي هنستخدمهم بعد ال frame و البناء كنا اتفقنا المرة الماضية ان انا في عندى لل frame", "tokens": [3555, 38251, 21984, 16070, 35571, 3215, 24976, 3224, 16070, 9381, 15040, 3660, 16070, 3794, 37440, 15844, 12602, 3794, 12610, 21984, 23032, 1829, 3555, 45595, 20498, 16472, 13412, 16606, 21984, 4724, 8315, 2655, 8032, 1863, 24793, 1211, 8978, 3714, 2407, 11242, 45367, 2423, 35942, 4195, 9226, 4032, 8032, 1863, 24793, 1211, 13412, 17082, 1211, 8315, 31439, 8717, 25957, 1211, 3131, 4724, 3794, 1829, 9566, 3660, 24976, 13333, 4032, 8717, 29399, 4587, 1211, 5296, 1045, 6677, 10874, 3215, 18513, 4032, 8032, 2304, 8032, 1829, 30544, 14407, 1975, 12610, 6677, 9154, 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{"start": 565.52, "end": 566.52, "word": " user", "probability": 0.82861328125}, {"start": 566.52, "end": 568.02, "word": " at", "probability": 0.2474365234375}], "temperature": 1.0}, {"id": 22, "seek": 58625, "start": 569.23, "end": 586.25, "text": "mail.com هاي ال user name لما انا بدي ارجع بالقيمة و افحصها لازم عبر ال method get و لو انا بدي اجيب من البرنامج و اعرض قيمة بدي استخدم ال set text تمام", "tokens": [11799, 13, 1112, 8032, 47302, 2423, 4195, 1315, 5296, 15042, 1975, 8315, 4724, 16254, 1975, 47341, 3615, 20666, 4587, 32640, 3660, 4032, 1975, 5172, 5016, 9381, 11296, 5296, 31377, 2304, 6225, 26890, 2423, 3170, 483, 4032, 45164, 1975, 8315, 4724, 16254, 1975, 7435, 1829, 3555, 9154, 2423, 26890, 8315, 2304, 7435, 4032, 1975, 3615, 43042, 12174, 32640, 3660, 4724, 16254, 44713, 9778, 40448, 2423, 992, 2487, 46811, 10943], "avg_logprob": -0.2276947524236596, "compression_ratio": 1.5, "no_speech_prob": 0.0, "words": [{"start": 569.23, "end": 569.61, "word": "mail", 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الـName تبعه لأ هذه الشغلات ممنوع يعدل عليها لأنه مش هو صاحب السلطة على تعديلها فإيش بروح بسوي أنا بروح بحدد", "tokens": [6027, 148, 48506, 5551, 5016, 1829, 7649, 14111, 995, 41850, 4724, 4587, 7578, 5551, 14851, 9778, 40448, 2423, 39184, 18643, 17952, 23758, 46599, 16254, 5551, 27842, 3615, 36632, 11331, 3215, 37495, 3215, 1211, 47356, 37495, 22653, 50113, 1211, 14111, 995, 41850, 4724, 28543, 2288, 5551, 32887, 5016, 5551, 3615, 43042, 46740, 9673, 14851, 9778, 40448, 12602, 4587, 2304, 3224, 2423, 2407, 19913, 33911, 1829, 4724, 3794, 37893, 8032, 38251, 5016, 43761, 7251, 32887, 5016, 37495, 3215, 1211, 8978, 12602, 4587, 2304, 3224, 2423, 2407, 19913, 33911, 1829, 34051, 37893, 8032, 38251, 5016, 43761, 37495, 3215, 1211, 8978, 2423, 39184, 47, 5830, 6055, 3555, 3615, 3224, 34051, 37893, 8032, 38251, 5016, 43761, 37495, 3215, 1211, 8978, 2423, 39184, 45, 529, 6055, 3555, 3615, 3224, 5296, 10721, 29538, 25124, 17082, 1211, 9307, 3714, 27842, 45367, 37495, 3215, 1211, 25894, 11296, 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الموجودة عندها لو أنا بدأ أسأل السؤال التالي لو أنا أتيت و رسمت لك forum بسيطة بالشكل هذا", "tokens": [1211, 39184, 20084, 346, 13821, 5296, 3615, 25708, 33427, 11622, 40228, 18863, 1863, 33546, 2288, 34051, 5296, 3615, 25708, 12602, 38251, 18863, 1863, 33546, 2288, 15844, 2423, 39184, 4831, 9673, 29245, 23328, 3660, 43242, 11296, 45164, 41850, 47525, 10721, 5551, 3794, 10721, 1211, 21136, 33604, 6027, 16712, 6027, 1829, 45164, 41850, 5551, 31371, 2655, 4032, 12602, 38251, 2655, 5296, 4117, 17542, 4724, 3794, 1829, 9566, 3660, 20666, 8592, 28820, 23758], "avg_logprob": -0.29445423626563916, "compression_ratio": 1.5433526011560694, "no_speech_prob": 0.0, "words": [{"start": 989.89, "end": 990.23, "word": "لـ", "probability": 0.5179443359375}, {"start": 990.23, "end": 990.63, "word": " Layout", "probability": 0.7568359375}, {"start": 990.63, "end": 991.03, "word": " Manager", "probability": 0.78564453125}, {"start": 991.03, "end": 991.91, "word": " لعيد", "probability": 0.60400390625}, 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انا بعمل click بيختفي انا بتكلم لأ default text لما انا بعمل place بيكون موجود وبيتظلل بالكامل عشان يمكنوا ان يمسحوا حسب حاجته طيب الآن معناته احنا متفقين ان ال text field هذا بدون بدون ال label هيكون", "tokens": [2655, 15042, 2304, 2423, 39184, 1081, 4104, 13672, 1829, 5296, 15042, 1975, 8315, 4724, 25957, 1211, 2052, 4724, 1829, 46456, 41185, 1975, 8315, 39894, 4117, 19528, 5296, 10721, 7576, 2487, 5296, 15042, 1975, 8315, 4724, 25957, 1211, 1081, 4724, 1829, 30544, 3714, 29245, 23328, 4032, 21292, 2655, 19913, 1211, 1211, 20666, 4117, 10943, 1211, 6225, 8592, 7649, 7251, 43020, 14407, 16472, 7251, 2304, 3794, 5016, 14407, 11331, 35457, 11331, 26108, 47395, 23032, 1829, 3555, 6024, 48506, 20449, 8315, 47395, 1975, 5016, 8315, 44650, 5172, 4587, 9957, 16472, 2423, 2487, 2519, 23758, 47525, 11536, 47525, 11536, 2423, 7645, 39896, 30544], "avg_logprob": -0.1742187559604645, "compression_ratio": 1.7452830188679245, "no_speech_prob": 0.0, "words": [{"start": 1220.82, "end": 1221.36, 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element تمام طب لو أنا بدي أكتب comment بحيث أنه لما أضغط enter أخد ال new line أو بين جسين لأن أنا بحتاج multiline text", "tokens": [49628, 35457, 8592, 2423, 39184, 3242, 23758, 2517, 8978, 2423, 11524, 4724, 32887, 5016, 9122, 33456, 4117, 6055, 17082, 9566, 1829, 15844, 3714, 5172, 2655, 39319, 2423, 24276, 5296, 33456, 31439, 6225, 3555, 9640, 3660, 18871, 958, 4846, 4478, 46811, 10943, 23032, 3555, 45164, 41850, 4724, 16254, 5551, 4117, 2655, 3555, 2871, 4724, 5016, 1829, 12984, 14739, 3224, 5296, 15042, 5551, 11242, 17082, 9566, 3242, 5551, 9778, 3215, 2423, 777, 1622, 34051, 49374, 10874, 3794, 9957, 5296, 33456, 41850, 4724, 33753, 26108, 2120, 388, 533, 2487], "avg_logprob": -0.2875359277615602, "compression_ratio": 1.4887892376681615, "no_speech_prob": 0.0, "words": [{"start": 2201.51, "end": 2202.09, "word": "بحسبش", "probability": 0.7498372395833334}, {"start": 2202.09, "end": 2202.25, "word": " الـ", "probability": 0.7685546875}, {"start": 2202.25, "end": 2202.47, "word": 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اللي موجودة عندها وكأنه .. أنا قاعد بقى أقوله حجم الـ text area تبعتها هي عبارة عن تمان أسطر و أربعين character في السطر الواحد حجم ال view تبعتها مش حجم ال data المدخلة نفس الكلام المطبق اللي يطبق على ال text field هو نفسه بيطبق .. طبق وين؟ على ال text area اللي موجودة عندها", "tokens": [6027, 39184, 1910, 13766, 6055, 3555, 34268, 3714, 9957, 22807, 6055, 3555, 34268, 2423, 39184, 2487, 1859, 13672, 1829, 3714, 29245, 23328, 3660, 43242, 11296, 4032, 4117, 33456, 3224, 4386, 41850, 12174, 995, 22488, 4724, 4587, 7578, 5551, 39648, 3224, 11331, 7435, 2304, 2423, 39184, 2487, 1859, 6055, 3555, 34268, 11296, 39896, 6225, 3555, 9640, 3660, 18871, 46811, 7649, 5551, 3794, 9566, 2288, 4032, 5551, 25513, 3615, 9957, 2517, 8978, 21136, 9566, 2288, 2423, 14407, 24401, 11331, 7435, 2304, 2423, 1910, 6055, 3555, 34268, 11296, 37893, 11331, 7435, 2304, 2423, 1412, 9673, 3215, 9778, 37977, 8717, 36178, 2423, 28820, 10943, 9673, 9566, 3555, 4587, 13672, 1829, 7251, 9566, 3555, 4587, 15844, 2423, 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new file mode 100644
index 0000000000000000000000000000000000000000..0c426a99ac8d9a52eeb46da4caff200797e015d3
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/O2ewNakCreI_raw.json
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"probability": 0.98291015625}, {"start": 795.7, "end": 795.78, "word": " ال", "probability": 0.65869140625}, {"start": 795.78, "end": 796.2, "word": " minimize", "probability": 0.7607421875}, {"start": 796.2, "end": 798.6, "word": " مظبوط؟", "probability": 0.7754313151041666}, {"start": 798.6, "end": 799.94, "word": " title", "probability": 0.77001953125}], "temperature": 1.0}, {"id": 29, "seek": 82933, "start": 801.73, "end": 829.33, "text": "الان الـ frame.normal هو الوضع التلقائي حسب الحجم و ال location اللي انت حددتيه لكن لو انا قلتله لل frame set extended side state و روحت قلتله frame maximized horizontal horizontal أفقي يعني احتل عرض الشاشة بالكامل و حافظ على الارتفاع اللي انا حددته إذا أنا قلتله maximize both", "tokens": [6027, 7649, 2423, 39184, 3920, 13, 23157, 31439, 2423, 2407, 11242, 3615, 16712, 1211, 4587, 16373, 1829, 11331, 35457, 21542, 7435, 2304, 4032, 2423, 4914, 13672, 1829, 16472, 2655, 11331, 3215, 3215, 31371, 3224, 44381, 45164, 1975, 8315, 12174, 1211, 2655, 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{"start": 810.79, "end": 811.25, "word": " قلتله", "probability": 0.84326171875}, {"start": 811.25, "end": 811.43, "word": " لل", "probability": 0.50146484375}, {"start": 811.43, "end": 811.75, "word": " frame", "probability": 0.6640625}, {"start": 811.75, "end": 812.11, "word": " set", "probability": 0.487060546875}, {"start": 812.11, "end": 812.67, "word": " extended", "probability": 0.57275390625}, {"start": 812.67, "end": 813.03, "word": " side", "probability": 0.1422119140625}, {"start": 813.03, "end": 813.63, "word": " state", "probability": 0.87548828125}, {"start": 813.63, "end": 814.09, "word": " و", "probability": 0.92041015625}, {"start": 814.09, "end": 814.35, "word": " روحت", "probability": 0.72265625}, {"start": 814.35, "end": 814.97, "word": " قلتله", "probability": 0.906005859375}, {"start": 814.97, "end": 816.05, "word": " frame", "probability": 0.8671875}, {"start": 816.05, "end": 817.01, "word": " maximized", "probability": 0.916259765625}, {"start": 817.01, "end": 817.69, "word": " horizontal", "probability": 0.62841796875}, {"start": 817.69, "end": 819.67, "word": " horizontal", "probability": 0.328857421875}, {"start": 819.67, "end": 820.11, "word": " أفقي", "probability": 0.88916015625}, {"start": 820.11, "end": 820.91, "word": " يعني", "probability": 0.960205078125}, {"start": 820.91, "end": 821.37, "word": " احتل", "probability": 0.9736328125}, {"start": 821.37, "end": 821.69, "word": " عرض", "probability": 0.986083984375}, {"start": 821.69, "end": 822.91, "word": " الشاشة", "probability": 0.98876953125}, {"start": 822.91, "end": 823.65, "word": " بالكامل", "probability": 0.976318359375}, {"start": 823.65, "end": 823.91, "word": " و", "probability": 0.974609375}, {"start": 823.91, "end": 824.25, "word": " حافظ", "probability": 0.9733072916666666}, {"start": 824.25, "end": 824.43, "word": " على", "probability": 0.71484375}, {"start": 824.43, "end": 824.93, "word": " الارتفاع", "probability": 0.95927734375}, {"start": 824.93, "end": 825.05, "word": " اللي", "probability": 0.982421875}, {"start": 825.05, "end": 825.19, "word": " انا", "probability": 0.830078125}, {"start": 825.19, "end": 825.69, "word": " حددته", "probability": 0.99072265625}, {"start": 825.69, "end": 827.65, "word": " إذا", "probability": 0.83251953125}, {"start": 827.65, "end": 827.83, "word": " أنا", "probability": 0.525390625}, {"start": 827.83, "end": 828.15, "word": " قلتله", "probability": 0.942626953125}, {"start": 828.15, "end": 828.59, "word": " maximize", "probability": 0.427978515625}, {"start": 828.59, "end": 829.33, "word": " both", "probability": 0.919921875}], "temperature": 1.0}, {"id": 30, "seek": 85965, "start": 830.43, "end": 859.65, "text": "وكأني اضغط على المفتاح هذا عشان يحتل الشاشة عملته Maximize iconified انه يعني عمله run لكنه مايظهرش ال frame لكنه بيظهر في ال taskbar وشريط المهام اللي موجود عندى خلينا نجربها على السريع ونكمل لو انا اجيت هان وروحت وقلت له jframe.setExtendedState", "tokens": [2407, 4117, 33456, 1829, 1975, 11242, 17082, 9566, 15844, 9673, 5172, 2655, 39319, 23758, 6225, 8592, 7649, 7251, 33753, 1211, 25124, 33599, 3660, 6225, 42213, 47395, 29076, 1125, 6528, 2587, 16472, 3224, 37495, 22653, 6225, 42213, 3224, 1190, 44381, 3224, 19446, 1829, 19913, 3224, 2288, 8592, 2423, 3920, 44381, 3224, 4724, 1829, 19913, 3224, 2288, 8978, 2423, 5633, 5356, 4032, 8592, 16572, 9566, 9673, 3224, 10943, 13672, 1829, 3714, 29245, 23328, 43242, 7578, 16490, 1211, 9957, 995, 8717, 7435, 25513, 11296, 15844, 21136, 16572, 3615, 4032, 1863, 24793, 1211, 45164, 1975, 8315, 1975, 7435, 36081, 8032, 7649, 4032, 32887, 33753, 4032, 4587, 1211, 2655, 46740, 361, 17265, 13, 3854, 36, 734, 3502, 4520, 473], "avg_logprob": -0.25027172980101214, "compression_ratio": 1.546875, "no_speech_prob": 0.0, "words": [{"start": 830.43, "end": 830.95, "word": "وكأني", "probability": 0.62933349609375}, {"start": 830.95, "end": 831.23, "word": " اضغط", "probability": 0.869140625}, {"start": 831.23, "end": 831.37, "word": " على", "probability": 0.71240234375}, {"start": 831.37, "end": 831.79, "word": " المفتاح", "probability": 0.985595703125}, {"start": 831.79, "end": 832.11, "word": " هذا", "probability": 0.6494140625}, {"start": 832.11, "end": 833.59, "word": " عشان", "probability": 0.87060546875}, {"start": 833.59, "end": 833.89, "word": " يحتل", "probability": 0.9615885416666666}, {"start": 833.89, "end": 834.41, "word": " الشاشة", "probability": 0.9923502604166666}, {"start": 834.41, "end": 834.71, "word": " عملته", "probability": 0.5774739583333334}, {"start": 834.71, "end": 835.35, "word": " Maximize", "probability": 0.6514892578125}, {"start": 835.35, "end": 836.81, "word": " iconified", "probability": 0.4296875}, {"start": 836.81, "end": 838.51, "word": " انه", "probability": 0.58935546875}, {"start": 838.51, "end": 838.75, "word": " يعني", "probability": 0.86474609375}, {"start": 838.75, "end": 839.13, "word": " عمله", "probability": 0.86474609375}, {"start": 839.13, "end": 839.27, "word": " run", "probability": 0.73388671875}, {"start": 839.27, "end": 839.93, "word": " لكنه", "probability": 0.88134765625}, {"start": 839.93, "end": 840.41, "word": " مايظهرش", "probability": 0.8611653645833334}, {"start": 840.41, "end": 840.53, "word": " ال", "probability": 0.783203125}, {"start": 840.53, "end": 840.79, "word": " frame", "probability": 0.74755859375}, {"start": 840.79, "end": 841.09, "word": " لكنه", "probability": 0.793701171875}, {"start": 841.09, "end": 841.37, "word": " بيظهر", "probability": 0.96748046875}, {"start": 841.37, "end": 841.53, "word": " في", "probability": 0.7216796875}, {"start": 841.53, "end": 841.71, "word": " ال", "probability": 0.6103515625}, {"start": 841.71, "end": 842.31, "word": " taskbar", "probability": 0.827392578125}, {"start": 842.31, "end": 843.45, "word": " وشريط", "probability": 0.744384765625}, {"start": 843.45, "end": 843.87, "word": " المهام", "probability": 0.9659830729166666}, {"start": 843.87, "end": 844.13, "word": " اللي", "probability": 0.917724609375}, {"start": 844.13, "end": 844.43, "word": " موجود", "probability": 0.9742838541666666}, {"start": 844.43, "end": 844.69, "word": " عندى", "probability": 0.667724609375}, {"start": 844.69, "end": 845.19, "word": " خلينا", "probability": 0.6448974609375}, {"start": 845.19, "end": 845.73, "word": " نجربها", "probability": 0.995849609375}, {"start": 845.73, "end": 846.23, "word": " على", "probability": 0.84228515625}, {"start": 846.23, "end": 846.71, "word": " السريع", "probability": 0.9762369791666666}, {"start": 846.71, "end": 848.69, "word": " ونكمل", "probability": 0.932373046875}, {"start": 848.69, "end": 850.29, "word": " لو", "probability": 0.74853515625}, {"start": 850.29, "end": 850.47, "word": " انا", "probability": 0.6822509765625}, {"start": 850.47, "end": 850.75, "word": " اجيت", "probability": 0.7833658854166666}, {"start": 850.75, "end": 851.11, "word": " هان", "probability": 0.6807861328125}, {"start": 851.11, "end": 852.31, "word": " وروحت", "probability": 0.6881510416666666}, {"start": 852.31, "end": 852.53, "word": " وقلت", "probability": 0.857666015625}, {"start": 852.53, "end": 852.81, "word": " له", "probability": 0.443359375}, {"start": 852.81, "end": 853.75, "word": " jframe", "probability": 0.5338134765625}, {"start": 853.75, "end": 859.65, "word": ".setExtendedState", "probability": 0.8420758928571429}], "temperature": 1.0}, {"id": 31, "seek": 88733, "start": 860.69, "end": 887.33, "text": "و JFrame Dot Maximized مثلا Horizontal لحالها هيرن Okay إيش لسه أنا عندها Maximize Horizontal صح Okay", "tokens": [2407, 508, 40305, 529, 38753, 29076, 1602, 50113, 15040, 42141, 896, 304, 5296, 5016, 6027, 11296, 8032, 13546, 1863, 1033, 11933, 1829, 8592, 5296, 3794, 3224, 41850, 43242, 11296, 29076, 1125, 42141, 896, 304, 20328, 5016, 1033], "avg_logprob": -0.37541119440605764, "compression_ratio": 1.1578947368421053, "no_speech_prob": 0.0, "words": [{"start": 860.69, "end": 860.91, "word": "و", "probability": 0.38818359375}, {"start": 860.91, "end": 861.67, "word": " JFrame", "probability": 0.66552734375}, {"start": 861.67, "end": 863.33, "word": " Dot", "probability": 0.302490234375}, {"start": 863.33, "end": 866.63, "word": " Maximized", "probability": 0.603759765625}, {"start": 866.63, "end": 868.43, "word": " مثلا", "probability": 0.931640625}, {"start": 868.43, "end": 869.87, "word": " Horizontal", "probability": 0.7317708333333334}, {"start": 869.87, "end": 870.47, "word": " لحالها", "probability": 0.948486328125}, {"start": 870.47, "end": 873.19, "word": " هيرن", "probability": 0.6903483072916666}, {"start": 873.19, "end": 875.33, "word": " Okay", "probability": 0.1571044921875}, {"start": 875.33, "end": 875.65, "word": " إيش", "probability": 0.7081705729166666}, {"start": 875.65, "end": 875.91, "word": " لسه", "probability": 0.8203125}, {"start": 875.91, "end": 876.05, "word": " أنا", "probability": 0.72998046875}, {"start": 876.05, "end": 876.89, "word": " عندها", "probability": 0.8662109375}, {"start": 876.89, "end": 883.45, "word": " Maximize", "probability": 0.779052734375}, {"start": 883.45, "end": 884.65, "word": " Horizontal", "probability": 0.8470052083333334}, {"start": 884.65, "end": 884.91, "word": " صح", "probability": 0.882080078125}, {"start": 884.91, "end": 887.33, "word": " Okay", "probability": 0.5224609375}], "temperature": 1.0}, {"id": 32, "seek": 90595, "start": 891.29, "end": 905.95, "text": "both غالبا ال set bound هى هى maximize طيب iconified ليش ال horizontal مش تغلقتش؟", "tokens": [18151, 32771, 6027, 3555, 995, 2423, 992, 5472, 8032, 7578, 8032, 7578, 19874, 23032, 1829, 3555, 6528, 2587, 32239, 8592, 2423, 12750, 37893, 6055, 17082, 1211, 4587, 2655, 8592, 22807], "avg_logprob": -0.37651209100600214, "compression_ratio": 1.0686274509803921, "no_speech_prob": 0.0, "words": [{"start": 891.2900000000001, "end": 892.21, "word": "both", "probability": 0.68603515625}, {"start": 892.21, "end": 893.13, "word": " غالبا", "probability": 0.872314453125}, {"start": 893.13, "end": 893.23, "word": " ال", "probability": 0.7705078125}, {"start": 893.23, "end": 893.39, "word": " set", "probability": 0.1904296875}, {"start": 893.39, "end": 893.73, "word": " bound", "probability": 0.791015625}, {"start": 893.73, "end": 896.41, "word": " هى", "probability": 0.6143798828125}, {"start": 896.41, "end": 896.85, "word": " هى", "probability": 0.6712646484375}, {"start": 896.85, "end": 897.99, "word": " maximize", "probability": 0.172607421875}, {"start": 897.99, "end": 901.59, "word": " طيب", "probability": 0.81103515625}, {"start": 901.59, "end": 903.37, "word": " iconified", "probability": 0.8642578125}, {"start": 903.37, "end": 904.55, "word": " ليش", "probability": 0.899658203125}, {"start": 904.55, "end": 904.63, "word": " ال", "probability": 0.962890625}, {"start": 904.63, "end": 904.97, "word": " horizontal", "probability": 0.8505859375}, {"start": 904.97, "end": 905.19, "word": " مش", "probability": 0.880859375}, {"start": 905.19, "end": 905.95, 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" frame", "probability": 0.494873046875}, {"start": 1030.67, "end": 1030.83, "word": " اللي", "probability": 0.986572265625}, {"start": 1030.83, "end": 1030.97, "word": " أنا", "probability": 0.6328125}, {"start": 1030.97, "end": 1031.53, "word": " عرفته", "probability": 0.9210611979166666}, {"start": 1031.53, "end": 1032.71, "word": " في", "probability": 0.92236328125}, {"start": 1032.71, "end": 1033.07, "word": " المثال", "probability": 0.986328125}, {"start": 1033.07, "end": 1033.49, "word": " تبعنا", "probability": 0.9049072265625}], "temperature": 1.0}, {"id": 37, "seek": 105996, "start": 1034.18, "end": 1059.96, "text": "لو أريد أن أضيف شيء سأقول له .add و هنا يجب أن أقول له أعطيه UI object حسب ما هو ال UI object اللي أريد أن أضيفه في النهاية لو أنا كلمت هل ال JFrame هو عبارة عن panel عبارة عن panel أنا بدي أرسم عليها العناصر اللي موجودة عندها كذلك في من ال panel في عندي ال class JPanel", "tokens": [1211, 2407, 5551, 16572, 3215, 14739, 5551, 11242, 33911, 44049, 38207, 8608, 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"probability": 0.98193359375}, {"start": 1056.62, "end": 1056.9, "word": " في", "probability": 0.48583984375}, {"start": 1056.9, "end": 1057.06, "word": " من", "probability": 0.81396484375}, {"start": 1057.06, "end": 1057.16, "word": " ال", "probability": 0.599609375}, {"start": 1057.16, "end": 1057.42, "word": " panel", "probability": 0.97119140625}, {"start": 1057.42, "end": 1057.86, "word": " في", "probability": 0.55322265625}, {"start": 1057.86, "end": 1058.28, "word": " عندي", "probability": 0.8369140625}, {"start": 1058.28, "end": 1059.34, "word": " ال", "probability": 0.45166015625}, {"start": 1059.34, "end": 1059.42, "word": " class", "probability": 0.556640625}, {"start": 1059.42, "end": 1059.96, "word": " JPanel", "probability": 0.802978515625}], "temperature": 1.0}, {"id": 38, "seek": 109073, "start": 1062.75, "end": 1090.73, "text": "وإذا بتذكري لما المرة الماضية اتكلمنا على العلاقة ما بين ال elements بشكل سريع نرجع لها الرسمة هيها قولت أنا في ال internal structure للجافة لل graphical user interface بالجافة أنا فيه عندي two containers ال frame اللي هي ال top level window والتانية فيه عندي ال panel و بعدين بالعلاقة بقدر أضيف عليهم ال button أو باج ال element وممكن أنا أضيفهم مباشرة علوين", "tokens": [2407, 28814, 15730, 39894, 8848, 4117, 16572, 5296, 15042, 9673, 25720, 9673, 46958, 10632, 1975, 2655, 4117, 19528, 8315, 15844, 18863, 15040, 28671, 19446, 49374, 2423, 4959, 4724, 8592, 28820, 8608, 16572, 3615, 8717, 47341, 3615, 5296, 11296, 34892, 38251, 3660, 39896, 11296, 12174, 12610, 2655, 41850, 8978, 2423, 6920, 3877, 24976, 7435, 31845, 3660, 24976, 35942, 4195, 9226, 20666, 7435, 31845, 3660, 41850, 8978, 3224, 18871, 16254, 732, 17089, 2423, 3920, 13672, 1829, 39896, 2423, 1192, 1496, 4910, 16070, 2655, 7649, 10632, 8978, 3224, 18871, 16254, 2423, 4831, 4032, 39182, 9957, 20666, 3615, 15040, 28671, 4724, 28543, 2288, 5551, 11242, 33911, 25894, 16095, 2423, 2960, 34051, 4724, 26108, 2423, 4478, 4032, 2304, 43020, 41850, 5551, 11242, 33911, 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"probability": 0.84765625}, {"start": 1082.63, "end": 1082.73, "word": " ال", "probability": 0.384765625}, {"start": 1082.73, "end": 1082.97, "word": " panel", "probability": 0.54052734375}, {"start": 1082.97, "end": 1083.25, "word": " و", "probability": 0.68701171875}, {"start": 1083.25, "end": 1083.55, "word": " بعدين", "probability": 0.815185546875}, {"start": 1083.55, "end": 1084.03, "word": " بالعلاقة", "probability": 0.8170166015625}, {"start": 1084.03, "end": 1084.39, "word": " بقدر", "probability": 0.9547526041666666}, {"start": 1084.39, "end": 1084.97, "word": " أضيف", "probability": 0.8504231770833334}, {"start": 1084.97, "end": 1086.37, "word": " عليهم", "probability": 0.982666015625}, {"start": 1086.37, "end": 1086.55, "word": " ال", "probability": 0.88330078125}, {"start": 1086.55, "end": 1086.85, "word": " button", "probability": 0.6337890625}, {"start": 1086.85, "end": 1087.33, "word": " أو", "probability": 0.5625}, {"start": 1087.33, "end": 1087.69, "word": " باج", 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0.64111328125}], "temperature": 1.0}, {"id": 64, "seek": 183713, "start": 1810.69, "end": 1837.13, "text": "محدد ال location مدنيش خطأ عليها السبب ان الاد تم تعريفها as overloading method ممكن تاخد ال location .. تاخد ال position لو كان ال default او ال layout manager اللي عندك border layout لو ماكنش موجود بتشتغل على ال argument الأول اللي بدها تضيفه تمام تعالى نشوف هنا high run راح اضاف ل button 1 و button 2", "tokens": [2304, 24401, 3215, 2423, 4914, 3714, 3215, 22653, 8592, 16490, 9566, 10721, 25894, 11296, 21136, 3555, 3555, 16472, 2423, 18513, 46811, 37279, 16572, 5172, 11296, 382, 28777, 278, 3170, 3714, 43020, 6055, 47283, 3215, 2423, 4914, 4386, 6055, 47283, 3215, 2423, 2535, 45164, 25961, 2423, 7576, 1975, 2407, 2423, 13333, 6598, 13672, 1829, 43242, 4117, 7838, 13333, 45164, 19446, 19452, 8592, 3714, 29245, 23328, 39894, 8592, 2655, 17082, 1211, 15844, 2423, 6770, 16247, 12610, 13672, 1829, 47525, 11296, 6055, 11242, 33911, 3224, 46811, 10943, 37279, 6027, 7578, 8717, 8592, 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"word": " تم", "probability": 0.98974609375}, {"start": 1814.79, "end": 1815.43, "word": " تعريفها", "probability": 0.9825439453125}, {"start": 1815.43, "end": 1815.65, "word": " as", "probability": 0.62646484375}, {"start": 1815.65, "end": 1816.37, "word": " overloading", "probability": 0.81103515625}, {"start": 1816.37, "end": 1816.75, "word": " method", "probability": 0.96728515625}, {"start": 1816.75, "end": 1817.23, "word": " ممكن", "probability": 0.9189453125}, {"start": 1817.23, "end": 1817.63, "word": " تاخد", "probability": 0.9143880208333334}, {"start": 1817.63, "end": 1817.71, "word": " ال", "probability": 0.8642578125}, {"start": 1817.71, "end": 1818.07, "word": " location", "probability": 0.837890625}, {"start": 1818.07, "end": 1818.15, "word": " ..", "probability": 0.31298828125}, {"start": 1818.15, "end": 1818.67, "word": " تاخد", "probability": 0.9715169270833334}, {"start": 1818.67, "end": 1819.53, "word": " ال", "probability": 0.9091796875}, {"start": 1819.53, "end": 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1824.31, "word": " layout", "probability": 0.94189453125}, {"start": 1824.31, "end": 1824.55, "word": " لو", "probability": 0.94580078125}, {"start": 1824.55, "end": 1824.95, "word": " ماكنش", "probability": 0.778076171875}, {"start": 1824.95, "end": 1825.47, "word": " موجود", "probability": 0.982421875}, {"start": 1825.47, "end": 1826.35, "word": " بتشتغل", "probability": 0.86962890625}, {"start": 1826.35, "end": 1826.49, "word": " على", "probability": 0.92529296875}, {"start": 1826.49, "end": 1826.61, "word": " ال", "probability": 0.955078125}, {"start": 1826.61, "end": 1826.99, "word": " argument", "probability": 0.9208984375}, {"start": 1826.99, "end": 1828.41, "word": " الأول", "probability": 0.8076171875}, {"start": 1828.41, "end": 1828.57, "word": " اللي", "probability": 0.970458984375}, {"start": 1828.57, "end": 1828.79, "word": " بدها", "probability": 0.6708984375}, {"start": 1828.79, "end": 1829.29, "word": " تضيفه", "probability": 0.9471435546875}, {"start": 1829.29, "end": 1829.73, "word": " تمام", "probability": 0.87548828125}, {"start": 1829.73, "end": 1831.85, "word": " تعالى", "probability": 0.8662109375}, {"start": 1831.85, "end": 1832.11, "word": " نشوف", "probability": 0.9973958333333334}, {"start": 1832.11, "end": 1832.39, "word": " هنا", "probability": 0.56494140625}, {"start": 1832.39, "end": 1832.95, "word": " high", "probability": 0.26025390625}, {"start": 1832.95, "end": 1833.21, "word": " run", "probability": 0.4423828125}, {"start": 1833.21, "end": 1835.65, "word": " راح", "probability": 0.902099609375}, {"start": 1835.65, "end": 1835.87, "word": " اضاف", "probability": 0.8898111979166666}, {"start": 1835.87, "end": 1835.97, "word": " ل", "probability": 0.83056640625}, {"start": 1835.97, "end": 1836.13, "word": " button", "probability": 0.61328125}, {"start": 1836.13, "end": 1836.47, "word": " 1", "probability": 0.7509765625}, {"start": 1836.47, "end": 1836.65, "word": " و", "probability": 0.9814453125}, {"start": 1836.65, "end": 1836.81, "word": " button", "probability": 0.84619140625}, {"start": 1836.81, "end": 1837.13, "word": " 2", "probability": 0.95751953125}], "temperature": 1.0}, {"id": 65, "seek": 186806, "start": 1838.8, "end": 1868.06, "text": "في السطر الأول و اعمل لهم alignment في الوسط لو انت بتغيري اول حاجة ال alignment تخليه اليامين او اليسار مباشرة من خلال ال constructor تابعت ال layout manager new flow layout هيه بروح مباشرة بقوله flow layout dot left ولا right ولا center left على سبيل المثال وبهيك انا بكون شغالة او حصلت على", "tokens": [41185, 21136, 9566, 2288, 16247, 12610, 4032, 1975, 25957, 1211, 5296, 16095, 18515, 8978, 2423, 41779, 9566, 45164, 16472, 2655, 39894, 17082, 13546, 1829, 1975, 12610, 11331, 26108, 3660, 2423, 18515, 6055, 9778, 20292, 3224, 45595, 10943, 9957, 1975, 2407, 45595, 3794, 9640, 3714, 3555, 33599, 25720, 9154, 16490, 1211, 6027, 2423, 47479, 6055, 16758, 34268, 2423, 13333, 6598, 777, 3095, 13333, 39896, 3224, 4724, 32887, 5016, 3714, 3555, 33599, 25720, 4724, 39648, 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اليسار", "probability": 0.9938151041666666}, {"start": 1847.08, "end": 1848.28, "word": " مباشرة", "probability": 0.9827880859375}, {"start": 1848.28, "end": 1848.42, "word": " من", "probability": 0.99462890625}, {"start": 1848.42, "end": 1848.7, "word": " خلال", "probability": 0.9943033854166666}, {"start": 1848.7, "end": 1848.84, "word": " ال", "probability": 0.796875}, {"start": 1848.84, "end": 1849.4, "word": " constructor", "probability": 0.751953125}, {"start": 1849.4, "end": 1851.0, "word": " تابعت", "probability": 0.7482096354166666}, {"start": 1851.0, "end": 1851.1, "word": " ال", "probability": 0.6884765625}, {"start": 1851.1, "end": 1851.38, "word": " layout", "probability": 0.7685546875}, {"start": 1851.38, "end": 1851.78, "word": " manager", "probability": 0.97509765625}, {"start": 1851.78, "end": 1852.1, "word": " new", "probability": 0.12939453125}, {"start": 1852.1, "end": 1852.56, "word": " flow", "probability": 0.80908203125}, {"start": 1852.56, "end": 1852.98, "word": " layout", "probability": 0.97802734375}, {"start": 1852.98, "end": 1853.5, "word": " هيه", "probability": 0.70947265625}, {"start": 1853.5, "end": 1855.08, "word": " بروح", "probability": 0.9261067708333334}, {"start": 1855.08, "end": 1855.48, "word": " مباشرة", "probability": 0.991943359375}, {"start": 1855.48, "end": 1856.1, "word": " بقوله", "probability": 0.7705078125}, {"start": 1856.1, "end": 1857.56, "word": " flow", "probability": 0.72705078125}, {"start": 1857.56, "end": 1858.92, "word": " layout", "probability": 0.94287109375}, {"start": 1858.92, "end": 1859.82, "word": " dot", "probability": 0.7880859375}, {"start": 1859.82, "end": 1860.68, "word": " left", "probability": 0.7919921875}, {"start": 1860.68, "end": 1860.9, "word": " ولا", "probability": 0.8515625}, {"start": 1860.9, "end": 1861.16, "word": " right", "probability": 0.958984375}, {"start": 1861.16, "end": 1861.38, "word": " ولا", "probability": 0.97314453125}, {"start": 1861.38, "end": 1861.82, "word": " center", "probability": 0.8125}, {"start": 1861.82, "end": 1863.16, "word": " left", "probability": 0.73193359375}, {"start": 1863.16, "end": 1863.38, "word": " على", "probability": 0.88818359375}, {"start": 1863.38, "end": 1863.68, "word": " سبيل", "probability": 0.9923502604166666}, {"start": 1863.68, "end": 1864.2, "word": " المثال", "probability": 0.9856770833333334}, {"start": 1864.2, "end": 1866.36, "word": " وبهيك", "probability": 0.8023681640625}, {"start": 1866.36, "end": 1866.5, "word": " انا", "probability": 0.868896484375}, {"start": 1866.5, "end": 1866.74, "word": " بكون", "probability": 0.953125}, {"start": 1866.74, "end": 1867.26, "word": " شغالة", "probability": 0.8240966796875}, {"start": 1867.26, "end": 1867.38, "word": " او", "probability": 0.900634765625}, {"start": 1867.38, "end": 1867.84, "word": " حصلت", "probability": 0.9264322916666666}, {"start": 1867.84, "end": 1868.06, "word": " على", "probability": 0.904296875}], "temperature": 1.0}, {"id": 66, "seek": 189687, "start": 1869.29, "end": 1896.87, "text": "أو قدرت أتحكم في الـ alignment المحاذاة تبع السطر في الـ flow layout لكن لاحظي الـ two buttons اللي هم نفس الحجم اللي هم نفس الحجم الآن بقدر أروح عليه السريع أضيف مجموعة من ال elements مجموعة من ال buttons لل frame اللي عندي Jframe.add", "tokens": [10721, 2407, 12174, 3215, 43500, 5551, 2655, 5016, 24793, 8978, 2423, 39184, 18515, 9673, 5016, 45636, 995, 3660, 6055, 3555, 3615, 21136, 9566, 2288, 8978, 2423, 39184, 3095, 13333, 44381, 20193, 5016, 19913, 1829, 2423, 39184, 732, 9905, 13672, 1829, 8032, 2304, 8717, 36178, 21542, 7435, 2304, 13672, 1829, 8032, 2304, 8717, 36178, 21542, 7435, 2304, 6024, 48506, 4724, 28543, 2288, 5551, 32887, 5016, 47356, 21136, 2288, 40228, 5551, 11242, 33911, 3714, 7435, 2304, 2407, 27884, 9154, 2423, 4959, 3714, 7435, 2304, 2407, 27884, 9154, 2423, 9905, 24976, 3920, 13672, 1829, 18871, 16254, 508, 17265, 13, 25224], "avg_logprob": -0.20089285805517312, "compression_ratio": 1.7476190476190476, 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flow", "probability": 0.37158203125}, {"start": 1873.93, "end": 1874.39, "word": " layout", "probability": 0.9521484375}, {"start": 1874.39, "end": 1875.75, "word": " لكن", "probability": 0.90185546875}, {"start": 1875.75, "end": 1876.27, "word": " لاحظي", "probability": 0.8414306640625}, {"start": 1876.27, "end": 1876.37, "word": " الـ", "probability": 0.78857421875}, {"start": 1876.37, "end": 1876.49, "word": " two", "probability": 0.80322265625}, {"start": 1876.49, "end": 1876.87, "word": " buttons", "probability": 0.87548828125}, {"start": 1876.87, "end": 1877.05, "word": " اللي", "probability": 0.8740234375}, {"start": 1877.05, "end": 1877.17, "word": " هم", "probability": 0.732666015625}, {"start": 1877.17, "end": 1877.47, "word": " نفس", "probability": 0.992431640625}, {"start": 1877.47, "end": 1879.09, "word": " الحجم", "probability": 0.9480794270833334}, {"start": 1879.09, "end": 1879.29, "word": " اللي", "probability": 0.961669921875}, {"start": 1879.29, "end": 1879.39, 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0.979736328125}, {"start": 1997.0, "end": 1997.44, "word": " يأثر", "probability": 0.8855794270833334}, {"start": 1997.44, "end": 1999.42, "word": " يعني", "probability": 0.744873046875}, {"start": 1999.42, "end": 1999.66, "word": " اجي", "probability": 0.79541015625}, {"start": 1999.66, "end": 1999.98, "word": " مثلا", "probability": 0.7366943359375}, {"start": 1999.98, "end": 2000.08, "word": " ل", "probability": 0.8740234375}, {"start": 2000.08, "end": 2000.3, "word": " button", "probability": 0.6923828125}, {"start": 2000.3, "end": 2000.76, "word": " 2", "probability": 0.72607421875}, {"start": 2000.76, "end": 2001.78, "word": " هان", "probability": 0.6903076171875}, {"start": 2001.78, "end": 2002.98, "word": " اقوله", "probability": 0.721923828125}, {"start": 2002.98, "end": 2003.62, "word": " dot", "probability": 0.462890625}, {"start": 2003.62, "end": 2004.48, "word": " set", "probability": 0.47216796875}, {"start": 2004.48, "end": 2005.02, "word": " size", "probability": 0.7802734375}, {"start": 2005.02, "end": 2006.16, "word": " أو", "probability": 0.65673828125}, {"start": 2006.16, "end": 2006.38, "word": " button", "probability": 0.8271484375}, {"start": 2006.38, "end": 2006.66, "word": " 1", "probability": 0.5458984375}, {"start": 2006.66, "end": 2007.74, "word": " عفوا", "probability": 0.8831380208333334}, {"start": 2007.74, "end": 2008.38, "word": " set", "probability": 0.75927734375}, {"start": 2008.38, "end": 2008.94, "word": " size", "probability": 0.83740234375}, {"start": 2008.94, "end": 2011.06, "word": " العرض", "probability": 0.9658203125}, {"start": 2011.06, "end": 2012.02, "word": " تبعه", "probability": 0.9056396484375}, {"start": 2012.02, "end": 2012.64, "word": " يكون", "probability": 0.988525390625}, {"start": 2012.64, "end": 2013.0, "word": " مثلا", "probability": 0.96533203125}, {"start": 2013.0, "end": 2014.02, "word": " 200", "probability": 0.8369140625}, {"start": 2014.02, "end": 2014.72, "word": " او", "probability": 0.893798828125}, {"start": 2014.72, "end": 2015.08, "word": " 100", "probability": 0.8056640625}], "temperature": 1.0}, {"id": 71, "seek": 204627, "start": 2019.23, "end": 2046.27, "text": "كما وهي الارتفاع عشرين الخطأ ليس من الـ two semicolon بالمناسبة الخطأ هنا من ال constructor عند ال constructor بيقول إيش ال type mismatched, could not convert انا بورجيكوا أن الخطأ ليس من ال two semicolon control X", "tokens": [4117, 15042, 37037, 1829, 2423, 9640, 2655, 5172, 45761, 6225, 46309, 9957, 33962, 9566, 10721, 32239, 3794, 9154, 2423, 39184, 732, 27515, 38780, 20666, 2304, 8315, 35457, 3660, 33962, 9566, 10721, 34105, 9154, 2423, 47479, 43242, 2423, 47479, 4724, 1829, 39648, 11933, 1829, 8592, 2423, 2010, 23220, 24102, 11, 727, 406, 7620, 1975, 8315, 4724, 13063, 7435, 1829, 4117, 14407, 14739, 33962, 9566, 10721, 32239, 3794, 9154, 2423, 732, 27515, 38780, 1969, 1783], "avg_logprob": -0.3642314112669713, "compression_ratio": 1.6329787234042554, "no_speech_prob": 0.0, "words": [{"start": 2019.23, "end": 2019.67, "word": "كما", "probability": 0.5498046875}, {"start": 2019.67, "end": 2020.55, "word": " وهي", "probability": 0.676025390625}, {"start": 2020.55, "end": 2021.01, "word": " الارتفاع", "probability": 0.89052734375}, {"start": 2021.01, "end": 2021.61, "word": " عشرين", "probability": 0.8502604166666666}, {"start": 2021.61, "end": 2030.97, "word": " الخطأ", "probability": 0.9567057291666666}, {"start": 2030.97, "end": 2031.11, "word": " ليس", "probability": 0.756103515625}, {"start": 2031.11, "end": 2031.23, "word": " من", "probability": 0.54345703125}, {"start": 2031.23, "end": 2031.31, "word": " الـ", "probability": 0.662841796875}, {"start": 2031.31, "end": 2031.41, "word": " two", "probability": 0.484130859375}, {"start": 2031.41, "end": 2031.91, "word": " semicolon", "probability": 0.66455078125}, {"start": 2031.91, "end": 2032.95, "word": " بالمناسبة", "probability": 0.98779296875}, {"start": 2032.95, "end": 2034.85, "word": " الخطأ", "probability": 0.9806315104166666}, {"start": 2034.85, "end": 2035.01, "word": " هنا", "probability": 0.29443359375}, {"start": 2035.01, "end": 2035.11, "word": " من", "probability": 0.66650390625}, {"start": 2035.11, "end": 2035.19, "word": " ال", "probability": 0.75927734375}, {"start": 2035.19, "end": 2035.69, "word": " constructor", "probability": 0.67626953125}, {"start": 2035.69, "end": 2035.93, "word": " عند", "probability": 0.425048828125}, {"start": 2035.93, "end": 2036.05, "word": " ال", "probability": 0.744140625}, {"start": 2036.05, "end": 2036.47, "word": " constructor", "probability": 0.9306640625}, {"start": 2036.47, "end": 2036.75, "word": " بيقول", "probability": 0.6554361979166666}, {"start": 2036.75, "end": 2037.57, "word": " إيش", "probability": 0.6219075520833334}, {"start": 2037.57, "end": 2038.05, "word": " ال", "probability": 0.56396484375}, {"start": 2038.05, "end": 2038.43, "word": " type", "probability": 0.8740234375}, {"start": 2038.43, "end": 2039.17, "word": " mismatched,", "probability": 0.7177734375}, {"start": 2039.23, "end": 2039.33, "word": " could", "probability": 0.71240234375}, {"start": 2039.33, "end": 2039.45, "word": " not", "probability": 0.962890625}, {"start": 2039.45, "end": 2040.19, "word": " convert", "probability": 0.92431640625}, {"start": 2040.19, "end": 2043.11, "word": " انا", "probability": 0.3243408203125}, {"start": 2043.11, "end": 2043.67, "word": " بورجيكوا", "probability": 0.6971842447916666}, {"start": 2043.67, "end": 2043.73, "word": " أن", "probability": 0.3388671875}, {"start": 2043.73, "end": 2044.03, "word": " الخطأ", "probability": 0.98779296875}, {"start": 2044.03, "end": 2044.15, "word": " ليس", "probability": 0.959228515625}, {"start": 2044.15, "end": 2044.27, "word": " من", "probability": 0.91162109375}, {"start": 2044.27, "end": 2044.35, "word": " ال", "probability": 0.921875}, {"start": 2044.35, "end": 2044.47, "word": " two", "probability": 0.74072265625}, {"start": 2044.47, "end": 2045.13, "word": " semicolon", "probability": 0.915283203125}, {"start": 2045.13, "end": 2045.73, "word": " control", "probability": 0.131103515625}, {"start": 2045.73, "end": 2046.27, "word": " X", "probability": 0.73486328125}], "temperature": 1.0}, {"id": 72, "seek": 206564, "start": 2048.08, "end": 2065.64, "text": "هي B dot control V بس ماشي .. المفروض .. okay أنا ويه الخطأ مستحيل يكون في ال two semicolon يعني ليش؟ ليش؟", "tokens": [3224, 1829, 363, 5893, 1969, 691, 4724, 3794, 3714, 33599, 1829, 4386, 9673, 5172, 32887, 11242, 4386, 1392, 41850, 4032, 1829, 3224, 33962, 9566, 10721, 3714, 14851, 5016, 26895, 7251, 30544, 8978, 2423, 732, 4361, 299, 38780, 37495, 22653, 32239, 8592, 22807, 32239, 8592, 22807], "avg_logprob": -0.40625000129575317, "compression_ratio": 1.144927536231884, "no_speech_prob": 0.0, "words": [{"start": 2048.08, "end": 2048.78, "word": "هي", "probability": 0.615478515625}, {"start": 2048.78, "end": 2049.2, "word": " B", "probability": 0.342529296875}, {"start": 2049.2, "end": 2049.94, "word": " dot", "probability": 0.343505859375}, {"start": 2049.94, "end": 2051.28, "word": " control", "probability": 0.369140625}, {"start": 2051.28, "end": 2056.32, "word": " V", "probability": 0.80712890625}, {"start": 2056.32, "end": 2057.62, "word": " بس", "probability": 0.562744140625}, {"start": 2057.62, "end": 2057.88, "word": " ماشي", "probability": 0.7195638020833334}, {"start": 2057.88, "end": 2058.1, "word": " ..", "probability": 0.184814453125}, {"start": 2058.1, "end": 2058.68, "word": " المفروض", "probability": 0.989990234375}, {"start": 2058.68, "end": 2058.78, "word": " ..", "probability": 0.5576171875}, {"start": 2058.78, "end": 2058.98, "word": " okay", "probability": 0.52294921875}, {"start": 2058.98, "end": 2059.26, "word": " أنا", "probability": 0.54150390625}, {"start": 2059.26, "end": 2059.92, "word": " ويه", "probability": 0.5953776041666666}, {"start": 2059.92, "end": 2060.58, "word": " الخطأ", "probability": 0.85009765625}, {"start": 2060.58, "end": 2061.38, "word": " مستحيل", "probability": 0.97265625}, {"start": 2061.38, "end": 2061.62, "word": " يكون", "probability": 0.994384765625}, {"start": 2061.62, "end": 2061.76, "word": " في", "probability": 0.9580078125}, {"start": 2061.76, "end": 2061.82, "word": " ال", "probability": 0.86376953125}, {"start": 2061.82, "end": 2061.92, "word": " two", "probability": 0.5361328125}, {"start": 2061.92, "end": 2062.5, "word": " semicolon", "probability": 0.5240478515625}, {"start": 2062.5, "end": 2062.74, "word": " يعني", "probability": 0.606689453125}, {"start": 2062.74, "end": 2065.0, "word": " ليش؟", "probability": 0.7259114583333334}, {"start": 2065.0, "end": 2065.64, "word": " ليش؟", "probability": 0.9563802083333334}], "temperature": 1.0}, {"id": 73, "seek": 209538, "start": 2067.68, "end": 2095.38, "text": "و بياخد واحدة semicolon بالنسبة إلى الجافة أو للغات البرمجة هي عبارة عن حالة أو نهاية الجملة يعني أنا بقول له أنها انتهيت إيش معنى الجملة السابقة الآن هسه من السيمي كولون فراح فحص الجملة هذه الأمورها تمام وراها سيمي كولون يعني إمتى statement بيعملها ignore و بيعمل move لل next element طيب الآن غيرت الحجم هي run تغير حجم بطولة واحد", "tokens": [2407, 4724, 1829, 47283, 3215, 36764, 24401, 3660, 27515, 38780, 20666, 1863, 35457, 3660, 30731, 25724, 31845, 3660, 34051, 5296, 1211, 17082, 9307, 2423, 26890, 2304, 7435, 3660, 39896, 6225, 3555, 9640, 3660, 18871, 11331, 6027, 3660, 34051, 8717, 11296, 10632, 25724, 2304, 37977, 37495, 22653, 41850, 4724, 39648, 46740, 14739, 11296, 16472, 47395, 36081, 11933, 1829, 8592, 20449, 1863, 7578, 25724, 2304, 37977, 21136, 16758, 28671, 6024, 48506, 8032, 3794, 3224, 9154, 21136, 32640, 1829, 9122, 12610, 11536, 6156, 23557, 5016, 6156, 5016, 9381, 25724, 2304, 37977, 29538, 16247, 2304, 13063, 11296, 46811, 10943, 4032, 23557, 11296, 8608, 32640, 1829, 9122, 12610, 11536, 37495, 22653, 11933, 2304, 49975, 5629, 4724, 1829, 25957, 1211, 11296, 11200, 4032, 4724, 1829, 25957, 1211, 1286, 24976, 958, 4478, 23032, 1829, 3555, 6024, 48506, 32771, 13546, 2655, 21542, 7435, 2304, 39896, 1190, 6055, 17082, 13546, 11331, 7435, 2304, 4724, 9566, 12610, 3660, 36764, 24401], "avg_logprob": -0.2781456965484366, "compression_ratio": 1.8825503355704698, "no_speech_prob": 0.0, "words": [{"start": 2067.68, "end": 2068.04, "word": "و", "probability": 0.2220458984375}, {"start": 2068.04, "end": 2068.44, "word": " بياخد", "probability": 0.735931396484375}, {"start": 2068.44, "end": 2068.88, "word": " واحدة", "probability": 0.91748046875}, {"start": 2068.88, "end": 2069.82, "word": " semicolon", "probability": 0.56402587890625}, {"start": 2069.82, "end": 2070.3, "word": " بالنسبة", "probability": 0.9688720703125}, {"start": 2070.3, "end": 2070.46, "word": " إلى", "probability": 0.347412109375}, {"start": 2070.46, "end": 2070.92, "word": " الجافة", "probability": 0.4642740885416667}, {"start": 2070.92, "end": 2071.06, "word": " أو", "probability": 0.8359375}, {"start": 2071.06, "end": 2071.34, "word": " للغات", "probability": 0.795166015625}, {"start": 2071.34, "end": 2071.86, "word": " البرمجة", "probability": 0.89755859375}, {"start": 2071.86, "end": 2072.4, "word": " هي", "probability": 0.77001953125}, {"start": 2072.4, "end": 2072.88, "word": " عبارة", "probability": 0.9647216796875}, {"start": 2072.88, "end": 2073.12, "word": " عن", "probability": 0.98779296875}, {"start": 2073.12, "end": 2073.58, "word": " حالة", "probability": 0.9415690104166666}, {"start": 2073.58, "end": 2073.72, "word": " أو", "probability": 0.8076171875}, {"start": 2073.72, "end": 2074.36, "word": " نهاية", "probability": 0.9674479166666666}, {"start": 2074.36, "end": 2075.4, "word": " الجملة", "probability": 0.9723307291666666}, {"start": 2075.4, "end": 2076.02, "word": " يعني", "probability": 0.92529296875}, {"start": 2076.02, "end": 2076.1, "word": " أنا", "probability": 0.64892578125}, {"start": 2076.1, "end": 2076.3, "word": " بقول", "probability": 0.8935546875}, {"start": 2076.3, "end": 2076.36, "word": " له", "probability": 0.368896484375}, {"start": 2076.36, "end": 2076.62, "word": " أنها", "probability": 0.42431640625}, {"start": 2076.62, "end": 2077.26, "word": " انتهيت", "probability": 0.8681640625}, {"start": 2077.26, "end": 2078.04, "word": " إيش", "probability": 0.7184651692708334}, {"start": 2078.04, "end": 2078.26, "word": " معنى", "probability": 0.7880859375}, {"start": 2078.26, "end": 2078.56, "word": " الجملة", "probability": 0.9700520833333334}, {"start": 2078.56, "end": 2079.08, "word": " السابقة", "probability": 0.98779296875}, {"start": 2079.08, "end": 2080.02, "word": " الآن", "probability": 0.7066650390625}, {"start": 2080.02, "end": 2080.46, "word": " هسه", "probability": 0.302978515625}, {"start": 2080.46, "end": 2080.52, "word": " من", "probability": 0.533203125}, {"start": 2080.52, "end": 2080.94, "word": " السيمي", "probability": 0.7522786458333334}, {"start": 2080.94, "end": 2081.24, "word": " كولون", "probability": 0.9147135416666666}, {"start": 2081.24, "end": 2081.56, "word": " فراح", "probability": 0.6878255208333334}, {"start": 2081.56, "end": 2081.84, "word": " فحص", "probability": 0.9371744791666666}, {"start": 2081.84, "end": 2082.18, "word": " الجملة", "probability": 0.9720052083333334}, {"start": 2082.18, "end": 2082.48, "word": " هذه", "probability": 0.7197265625}, {"start": 2082.48, "end": 2083.4, "word": " الأمورها", "probability": 0.7750244140625}, {"start": 2083.4, "end": 2083.68, "word": " تمام", "probability": 0.918701171875}, {"start": 2083.68, "end": 2084.62, "word": " وراها", "probability": 0.9710286458333334}, {"start": 2084.62, "end": 2084.94, "word": " سيمي", "probability": 0.788818359375}, {"start": 2084.94, "end": 2085.84, "word": " كولون", "probability": 0.9708658854166666}, {"start": 2085.84, "end": 2086.08, "word": " يعني", "probability": 0.97412109375}, {"start": 2086.08, "end": 2086.44, "word": " إمتى", "probability": 0.531982421875}, {"start": 2086.44, "end": 2087.0, "word": " statement", "probability": 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"probability": 0.8154296875}, {"start": 2412.8, "end": 2413.08, "word": " element", "probability": 0.98388671875}, {"start": 2413.08, "end": 2413.42, "word": " بتصير", "probability": 0.8681640625}, {"start": 2413.42, "end": 2413.8, "word": " أحددله", "probability": 0.90234375}, {"start": 2413.8, "end": 2414.22, "word": " حجم", "probability": 0.998046875}, {"start": 2414.22, "end": 2414.8, "word": " و", "probability": 0.98876953125}, {"start": 2414.8, "end": 2415.18, "word": " location", "probability": 0.98974609375}, {"start": 2415.18, "end": 2415.64, "word": " وهنا", "probability": 0.6986083984375}, {"start": 2415.64, "end": 2416.1, "word": " بتبرز", "probability": 0.9549153645833334}, {"start": 2416.1, "end": 2416.78, "word": " أهمية", "probability": 0.9860026041666666}, {"start": 2416.78, "end": 2417.38, "word": " ال", "probability": 0.93701171875}, {"start": 2417.38, "end": 2417.6, "word": " set", "probability": 0.20849609375}, {"start": 2417.6, "end": 2418.04, "word": " bound", "probability": 0.6142578125}, {"start": 2418.04, "end": 2418.64, "word": " method", "probability": 0.98974609375}], "temperature": 1.0}, {"id": 86, "seek": 244342, "start": 2419.94, "end": 2443.42, "text": "بنشوفها لاحقا إن شاء الله تعالى في أي سؤال يا بنات؟ لأنه افترض إن عدد الصفوف ثابت قدم عدد الصفوف على عدد الأعمدة وانت الآن بتضيفي عناصر أكتر من حجم ال grid الحل؟ راح أضافلي وين؟ صفة جديدة السؤال الأخير لو أنا غيرت حجم ال window هنا إيش اللي بتغير؟", "tokens": [3555, 1863, 8592, 38688, 11296, 20193, 5016, 4587, 995, 36145, 13412, 16606, 21984, 37279, 6027, 7578, 8978, 36632, 8608, 33604, 6027, 35186, 4724, 8315, 2655, 22807, 5296, 33456, 3224, 1975, 5172, 2655, 43042, 36145, 6225, 3215, 3215, 31767, 5172, 38688, 38637, 16758, 2655, 12174, 40448, 6225, 3215, 3215, 31767, 5172, 38688, 15844, 6225, 3215, 3215, 16247, 25957, 41891, 4032, 7649, 2655, 6024, 48506, 39894, 11242, 33911, 1829, 18871, 33546, 2288, 5551, 4117, 2655, 2288, 9154, 11331, 7435, 2304, 2423, 10748, 21542, 1211, 22807, 12602, 39319, 5551, 11242, 31845, 20292, 4032, 9957, 22807, 20328, 5172, 3660, 10874, 16254, 41891, 21136, 33604, 6027, 16247, 9778, 13546, 45164, 41850, 32771, 13546, 2655, 11331, 7435, 2304, 2423, 4910, 34105, 11933, 1829, 8592, 13672, 1829, 39894, 17082, 13546, 22807], "avg_logprob": -0.1655000047683716, "compression_ratio": 1.7901234567901234, "no_speech_prob": 0.0, "words": [{"start": 2419.94, "end": 2420.6, "word": "بنشوفها", "probability": 0.84873046875}, {"start": 2420.6, "end": 2420.94, "word": " لاحقا", "probability": 0.8826904296875}, {"start": 2420.94, "end": 2421.04, "word": " إن", "probability": 0.2138671875}, {"start": 2421.04, "end": 2421.12, "word": " شاء", "probability": 0.9658203125}, {"start": 2421.12, "end": 2421.2, "word": " الله", "probability": 0.96240234375}, {"start": 2421.2, "end": 2421.52, "word": " تعالى", "probability": 0.9283854166666666}, {"start": 2421.52, "end": 2421.82, "word": " في", "probability": 0.296875}, {"start": 2421.82, "end": 2421.96, "word": " أي", "probability": 0.7109375}, {"start": 2421.96, "end": 2422.18, "word": " سؤال", "probability": 0.9918619791666666}, {"start": 2422.18, "end": 2422.28, "word": " يا", "probability": 0.98046875}, {"start": 2422.28, "end": 2424.28, "word": " بنات؟", "probability": 0.81982421875}, {"start": 2424.28, "end": 2426.56, "word": " لأنه", "probability": 0.748046875}, {"start": 2426.56, "end": 2426.92, "word": " افترض", "probability": 0.96435546875}, {"start": 2426.92, "end": 2427.04, "word": " إن", "probability": 0.416015625}, {"start": 2427.04, "end": 2427.3, "word": " عدد", "probability": 0.86669921875}, {"start": 2427.3, "end": 2427.68, "word": " الصفوف", "probability": 0.9835611979166666}, {"start": 2427.68, "end": 2428.08, "word": " ثابت", "probability": 0.9923502604166666}, {"start": 2428.08, "end": 2428.44, "word": " قدم", "probability": 0.884765625}, {"start": 2428.44, "end": 2428.66, "word": " عدد", "probability": 0.9915364583333334}, {"start": 2428.66, "end": 2429.04, "word": " الصفوف", "probability": 0.9759114583333334}, {"start": 2429.04, "end": 2429.22, "word": " على", "probability": 0.7900390625}, {"start": 2429.22, "end": 2429.44, "word": " عدد", "probability": 0.9890950520833334}, {"start": 2429.44, "end": 2429.9, "word": " الأعمدة", "probability": 0.8831380208333334}, {"start": 2429.9, "end": 2430.36, "word": " وانت", "probability": 0.8282877604166666}, {"start": 2430.36, "end": 2430.6, "word": " الآن", "probability": 0.763916015625}, {"start": 2430.6, "end": 2431.42, "word": " بتضيفي", "probability": 0.958251953125}, {"start": 2431.42, "end": 2432.38, "word": " عناصر", "probability": 0.9894205729166666}, {"start": 2432.38, "end": 2432.76, "word": " أكتر", "probability": 0.9462890625}, {"start": 2432.76, "end": 2432.98, "word": " من", "probability": 0.99365234375}, {"start": 2432.98, "end": 2433.26, "word": " حجم", "probability": 0.9951171875}, {"start": 2433.26, "end": 2433.38, "word": " ال", "probability": 0.90869140625}, {"start": 2433.38, "end": 2433.72, "word": " grid", "probability": 0.6533203125}, {"start": 2433.72, "end": 2435.32, "word": " الحل؟", "probability": 0.8525390625}, {"start": 2435.32, "end": 2435.54, "word": " راح", "probability": 0.5816650390625}, {"start": 2435.54, "end": 2435.92, "word": " أضافلي", "probability": 0.7958984375}, {"start": 2435.92, "end": 2436.92, "word": " وين؟", "probability": 0.8487955729166666}, {"start": 2436.92, "end": 2437.3, "word": " صفة", "probability": 0.6868489583333334}, {"start": 2437.3, "end": 2437.56, "word": " جديدة", "probability": 0.9580078125}, {"start": 2437.56, "end": 2438.12, "word": " السؤال", "probability": 0.8225911458333334}, {"start": 2438.12, "end": 2438.4, "word": " الأخير", "probability": 0.8966471354166666}, {"start": 2438.4, "end": 2438.54, "word": " لو", "probability": 0.55419921875}, {"start": 2438.54, "end": 2438.76, "word": " أنا", "probability": 0.85595703125}, {"start": 2438.76, "end": 2439.36, "word": " غيرت", "probability": 0.9638671875}, {"start": 2439.36, "end": 2440.72, "word": " حجم", "probability": 0.9957682291666666}, {"start": 2440.72, "end": 2440.86, "word": " ال", "probability": 0.966796875}, {"start": 2440.86, "end": 2441.12, "word": " window", "probability": 0.75341796875}, {"start": 2441.12, "end": 2441.48, "word": " هنا", "probability": 0.324462890625}, {"start": 2441.48, "end": 2442.6, "word": " إيش", "probability": 0.792236328125}, {"start": 2442.6, "end": 2442.7, "word": " اللي", "probability": 0.990966796875}, {"start": 2442.7, "end": 2443.42, "word": " بتغير؟", "probability": 0.95068359375}], "temperature": 1.0}, {"id": 87, "seek": 245094, "start": 2446.6, "end": 2450.94, "text": "حجم العمود فقط فقط حجم العمود الله يعطيكم العافية", "tokens": [5016, 7435, 2304, 18863, 2304, 23328, 6156, 47432, 6156, 47432, 11331, 7435, 2304, 18863, 2304, 23328, 21984, 37495, 9566, 1829, 24793, 18863, 31845, 10632], "avg_logprob": -0.1871875047683716, "compression_ratio": 1.3846153846153846, "no_speech_prob": 0.0, "words": [{"start": 2446.6, "end": 2447.14, "word": "حجم", "probability": 0.9005533854166666}, {"start": 2447.14, "end": 2447.54, "word": " العمود", "probability": 0.9820963541666666}, {"start": 2447.54, "end": 2447.94, "word": " فقط", "probability": 0.972412109375}, {"start": 2447.94, "end": 2448.86, "word": " فقط", "probability": 0.7119140625}, {"start": 2448.86, "end": 2449.26, "word": " حجم", "probability": 0.9793294270833334}, {"start": 2449.26, "end": 2449.92, "word": " العمود", "probability": 0.98681640625}, {"start": 2449.92, "end": 2450.5, "word": " الله", "probability": 0.8232421875}, {"start": 2450.5, "end": 2450.72, "word": " يعطيكم", "probability": 0.764404296875}, {"start": 2450.72, "end": 2450.94, "word": " العافية", "probability": 0.8478190104166666}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2451.2145, "duration_after_vad": 2255.2843749999915}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/_otKGxh2IwU.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/_otKGxh2IwU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4936b54eadf140eceb733f556392ca3785bdb098
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/_otKGxh2IwU.srt
@@ -0,0 +1,1843 @@
+1
+00:00:20,650 --> 00:00:22,910
+باسم الله والحمد لله والصلاة والسلام على رسول الله
+
+2
+00:00:22,910 --> 00:00:29,970
+زي ما قعدتكم إن شاء الله اليوم هنشتغل الـ code
+
+3
+00:00:29,970 --> 00:00:34,350
+العاملي تبع الـ Java Networking مثل ما اشتغلنا مع
+
+4
+00:00:34,350 --> 00:00:39,090
+الـ database أو غيرها إن شاء الله بتكون بتحصل
+
+5
+00:00:39,090 --> 00:00:42,870
+الفايدة الموجودة وإذا كان في أي labs أو أي غموض في
+
+6
+00:00:42,870 --> 00:00:46,850
+موضوع الـ Java Networking بتزول اليوم بإذن الله
+
+7
+00:00:46,850 --> 00:00:49,950
+تعالى الـ socket
+
+8
+00:00:52,720 --> 00:00:58,200
+هاني بدأت شغلتي الـ eclipse وانشأت project
+
+9
+00:00:58,200 --> 00:01:06,740
+جديد سميته socket project وطبعًا اتفقنا من اللقاءات
+
+10
+00:01:06,740 --> 00:01:09,700
+السابقة أنه لو اتكلم على network programming
+
+11
+00:01:09,700 --> 00:01:13,040
+بلزمني أعمل implementation لـ two different
+
+12
+00:01:13,040 --> 00:01:19,240
+applications واحد للـ server و واحد للـ client يعني
+
+13
+00:01:19,240 --> 00:01:22,840
+إن أنا هروح أنشأ الـ two classes في الأول هي بدي
+
+14
+00:01:22,840 --> 00:01:30,980
+أسمي الـ server class و
+
+15
+00:01:30,980 --> 00:01:34,020
+بدي الـ void و بدي الـ main يكون موجودة و بدي أعمل
+
+16
+00:01:34,020 --> 00:01:39,460
+كمان واحد أسميه client لازم يكونوا في نفس الـ
+
+17
+00:01:39,460 --> 00:01:42,360
+application أو نفس الـ project مش ضروري يعني ممكن
+
+18
+00:01:42,360 --> 00:01:44,740
+يكونوا different applications و الأصل أن هدول
+
+19
+00:01:44,740 --> 00:01:47,400
+يكونوا على different machine على جهازين مختلفين
+
+20
+00:01:47,400 --> 00:01:50,200
+with different ip address و هذا بدي أسميه أنا
+
+21
+00:01:50,200 --> 00:01:51,180
+client
+
+22
+00:01:58,310 --> 00:02:06,970
+class and two applications موجودات عندنا قلنا الـ
+
+23
+00:02:06,970 --> 00:02:09,910
+server-side أو الـ server-class لازم يكون معمل له
+
+24
+00:02:09,910 --> 00:02:14,650
+coding بالبداية و أول سطر فيه إن أنا بتعرف شغلة
+
+25
+00:02:14,650 --> 00:02:17,710
+اسمها الـ server-socket و بهذه بهو بتميز فيها الـ
+
+26
+00:02:17,710 --> 00:02:22,010
+server-socket server
+
+27
+00:02:26,930 --> 00:02:33,530
+Socket الـ C ساوي الـ New Server Socket وقلنا إن
+
+28
+00:02:33,530 --> 00:02:38,530
+الـ Server Socket تلزم نحدد Port وهذه الـ Socket
+
+29
+00:02:38,530 --> 00:02:42,290
+مهمتها تخلّي الـ Server Side بيعمل Listening لأي
+
+30
+00:02:42,290 --> 00:02:47,110
+request يعني وكانوا بيخلّي الجوال شغال عشان لما أي
+
+31
+00:02:47,110 --> 00:02:51,110
+حد يتصل عليا يكون يكون جاهز لاستقبال الرسالة
+
+32
+00:02:51,110 --> 00:02:54,030
+اللى موجود عندي أو استقبال الاتصال اللي جاي طيب
+
+33
+00:02:54,030 --> 00:02:56,610
+ايش رقم الـ port اللي أنا أختاره أنا قلت لكم
+
+34
+00:02:56,610 --> 00:03:01,110
+بالحرف الواحد من واحد لحد الف واربع وعشرين هدول الـ
+
+35
+00:03:01,110 --> 00:03:04,610
+ports محجوزة للـ operating system وبالتالي أنت بدك
+
+36
+00:03:04,610 --> 00:03:08,350
+تختار Port برة الـ range هذا طيب يعني ممكن أنا
+
+37
+00:03:08,350 --> 00:03:13,870
+أختار مثلًا عشرين تلاتين as port بيمشي الحال واحنا
+
+38
+00:03:13,870 --> 00:03:18,510
+بيقول لك عدد الـ port بتوصل لحد 65 ألف قليل
+
+39
+00:03:18,510 --> 00:03:23,990
+وبالتالي هذا الـ port okay تمام أنا هيك عرفت الـ
+
+40
+00:03:23,990 --> 00:03:27,870
+server socket الـ server socket تعمل generation لـ
+
+41
+00:03:27,870 --> 00:03:30,550
+exception أو تعمل raise لـ exception هاي بدي أحطها
+
+42
+00:03:30,550 --> 00:03:35,770
+ضمن throw أو try to catch لأنها بتعمل throw لـ
+
+43
+00:03:35,770 --> 00:03:41,490
+input output exception تمام ما هي الخطوة التالية
+
+44
+00:03:41,490 --> 00:03:45,050
+بعد ذلك؟ المفروض أن أجعل الـ server يعمل الـ
+
+45
+00:03:45,050 --> 00:03:48,030
+listening والـ listening يتم خلال الـ method اسمها
+
+46
+00:03:48,030 --> 00:03:52,850
+accept هذه الـ socket طب أنا هقول عشان يظل ... شوفي
+
+47
+00:03:52,850 --> 00:03:56,930
+لو أنا كتبت له الـ socket أو الـ server socket dot
+
+48
+00:03:56,930 --> 00:04:04,390
+accept هيك هيعمل request أو يظل ينتظر connection
+
+49
+00:04:04,390 --> 00:04:10,040
+واحد فقط بمجرد إنه يقبل الـ connection مثلًا هاي
+
+50
+00:04:10,040 --> 00:04:24,680
+بتحط هنا جملة طباعة as out I end of server code
+
+51
+00:04:24,680 --> 00:04:29,580
+نهاية الـ server code اللي موجود عندها بمجرد تيجي
+
+52
+00:04:29,580 --> 00:04:34,180
+الـ connection و بتنقبل الـ accept كل هذه بترجع بـ
+
+53
+00:04:34,180 --> 00:04:39,380
+object من نوع socket معناته سأقول له socket client
+
+54
+00:04:39,380 --> 00:04:45,460
+equal و سنسميه sv هذا على أنها server sv sv وهذا
+
+55
+00:04:45,460 --> 00:04:56,300
+client import plus socket كمان الأيام قبل هي دي
+
+56
+00:04:56,300 --> 00:04:59,120
+المفروض ندخل في مرحلة الـ wait يعني هيواجه عند الـ
+
+57
+00:04:59,120 --> 00:05:06,780
+accept وليس هيكمل هي us out weighting
+
+58
+00:05:07,430 --> 00:05:16,550
+for new connection تمام
+
+59
+00:05:16,550 --> 00:05:22,470
+طيب هيك خلاص الـ socket جاهزة اه جاهزة تعالى نشوفها
+
+60
+00:05:22,470 --> 00:05:26,590
+في
+
+61
+00:05:26,590 --> 00:05:30,650
+الـ client هروح أعرف socket من البداية
+
+62
+00:05:33,650 --> 00:05:36,570
+الـ new socket و الـ socket object بتاخد مني
+
+63
+00:05:36,570 --> 00:05:42,950
+شغلتين بتاخد مني الـ host name أو الـ IP address
+
+64
+00:05:42,950 --> 00:05:46,270
+تبع الـ server ايش الـ server و الـ IP address تبعته
+
+65
+00:05:46,270 --> 00:05:50,130
+احنا بما إنه أنا الآن بشتغل على نفس الجهاز اما
+
+66
+00:05:50,130 --> 00:05:59,570
+بكتب له localhost تمام أو بأضيف الـ IP address 127
+
+67
+00:05:59,570 --> 00:06:01,910
+.0
+
+68
+00:06:02,640 --> 00:06:07,500
+.0.1 اللي احنا بيسميه الـ loopback address أو الـ
+
+69
+00:06:07,500 --> 00:06:13,140
+local IP address طب الـ port بدي أضيف الـ port اللي
+
+70
+00:06:13,140 --> 00:06:20,920
+أضفته عند الـ server اللي سميناه كتاب عشرين تلاتين و
+
+71
+00:06:20,920 --> 00:06:27,860
+طبعًا هذه بتعمل برضه raise the exception
+
+72
+00:06:32,530 --> 00:06:36,730
+لاحظي الآن الـ basics أو الـ component الخاصة بالـ
+
+73
+00:06:36,730 --> 00:06:40,630
+connection جاهزة وفيه أجربها أنا الآن أشغل الـ
+
+74
+00:06:40,630 --> 00:06:46,190
+server waiting for a new connection يعني وين هان؟
+
+75
+00:06:46,190 --> 00:06:50,990
+والآن لاحظي هو موصلش للنهاية لأنه واقف في مرحلة
+
+76
+00:06:50,990 --> 00:06:54,890
+accept لأنه قاعد يعمل wait هنتظر أروح أشغل الـ
+
+77
+00:06:54,890 --> 00:07:00,930
+client الـ client المفروض لاحظي
+
+78
+00:07:01,670 --> 00:07:04,730
+ايش طبعًا للـ server؟ end of server code اللي هي
+
+79
+00:07:04,730 --> 00:07:10,370
+الجملة الأخيرة بمعنى آخر هو accepted الـ connection
+
+80
+00:07:10,370 --> 00:07:16,450
+تبعي وكمل لنهاية الـ code اللي موجود طيب الآن هل لو
+
+81
+00:07:16,450 --> 00:07:19,090
+في عند كمان clients بدأ شغله كمان مرة حيشغل؟
+
+82
+00:07:20,150 --> 00:07:23,990
+الكل تأكيدًا لا connection refused ليش؟ لأن أنا عامل
+
+83
+00:07:23,990 --> 00:07:27,090
+الـ listening لمرة واحدة لأن أنا عامل الـ listening
+
+84
+00:07:27,090 --> 00:07:32,410
+لمرة واحدة قبل الحل بدي أعمل while تظل شغالة إلى
+
+85
+00:07:32,410 --> 00:07:34,710
+ما لا نهاية بدي أعمل while تظل شغالة إلى ما لا
+
+86
+00:07:34,710 --> 00:07:40,510
+نهاية while
+
+87
+00:07:40,510 --> 00:07:44,370
+true infinite loop
+
+88
+00:08:03,790 --> 00:08:13,710
+حاول اعمل format للـ code source format while while
+
+89
+00:08:13,710 --> 00:08:25,390
+true صحيح ايش في عندنا هان؟
+
+90
+00:08:25,390 --> 00:08:26,110
+نعم
+
+91
+00:08:30,050 --> 00:08:32,750
+أما هي أنا بدي إياها بقى لا مش بعد الـ try بعد الـ
+
+92
+00:08:32,750 --> 00:08:38,030
+while هي الـ ghost هي الـ ghost تبع الـ while هي بس
+
+93
+00:08:38,030 --> 00:08:42,310
+ليش مدي عليها خطأ مش .. لا حاول ولا قوة يا الله
+
+94
+00:08:42,310 --> 00:08:46,310
+بالله source
+
+95
+00:08:46,310 --> 00:08:51,390
+format name
+
+96
+00:08:51,390 --> 00:08:53,030
+end
+
+97
+00:08:59,370 --> 00:09:02,910
+unreachable code يعني وكأنه معتبرها برة الـ try
+
+98
+00:09:02,910 --> 00:09:06,810
+يعني
+
+99
+00:09:06,810 --> 00:09:10,410
+هاي الـ try و هي كانت جواها هي كانت جواها الـ try
+
+100
+00:09:10,410 --> 00:09:13,150
+أنا فاهمها بس ليش هو بيقول لي unreachable code
+
+101
+00:09:13,150 --> 00:09:16,210
+anyway
+
+102
+00:09:16,210 --> 00:09:20,330
+بدناش نظل واقفين هنا نحاول نشوف ايش المشكلة في
+
+103
+00:09:20,330 --> 00:09:27,630
+الخطأ اللي موجود هنا تمام الآن بدي أشغل الـ server و
+
+104
+00:09:27,630 --> 00:09:32,250
+بس عشان أتأكد إنه فعليًا صار في connection وأكد على
+
+105
+00:09:32,250 --> 00:09:34,870
+شغل تاني هلأ كنت بقول لك إياها هيبدأ يطبع الآن
+
+106
+00:09:34,870 --> 00:09:38,350
+connection
+
+107
+00:09:38,350 --> 00:09:43,290
+has
+
+108
+00:09:43,290 --> 00:09:49,810
+been established تمام الـ new connection has been
+
+109
+00:09:49,810 --> 00:09:53,010
+established تمام هيران؟
+
+110
+00:09:54,420 --> 00:09:59,060
+هي الآن الـ server بيعمل waiting لما أروح أشغل الـ
+
+111
+00:09:59,060 --> 00:10:04,060
+client اشرح قال لي connection has been established
+
+112
+00:10:04,060 --> 00:10:07,520
+ورجع مرة ثانية لـ while وعامل wait for income
+
+113
+00:10:07,520 --> 00:10:11,400
+request طب لو أنا بدي كمان client بقدر اه بقدر أشغل
+
+114
+00:10:11,400 --> 00:10:15,040
+الـ application تبع الـ client كمان مرة هاي كمان مرة
+
+115
+00:10:15,040 --> 00:10:18,400
+هاي قال لي a new connection has been established و
+
+116
+00:10:18,400 --> 00:10:23,100
+بعمل wait وهاي كمان مرة الآن أنا قاعد بقول إن في
+
+117
+00:10:23,100 --> 00:10:26,040
+عندي three different clients عاملة connect مع مين؟
+
+118
+00:10:26,040 --> 00:10:30,100
+مع الـ server الآن من المرة الماضية أو المحاضرة
+
+119
+00:10:30,100 --> 00:10:34,040
+الماضية قلت كلمة مهمة جدًا إن الـ server socket لا
+
+120
+00:10:34,040 --> 00:10:37,680
+تستخدم من أجل نقل البيانات فقط من أجل تحقيق
+
+121
+00:10:37,680 --> 00:10:41,140
+الاتصال طب مين الـ socket المسؤول عن نقل البيانات؟
+
+122
+00:10:41,140 --> 00:10:46,510
+الـ socket الـ socket هذه اللحظة اللي موجودة عند الـ
+
+123
+00:10:46,510 --> 00:10:50,130
+client و الـ socket هذه اللي كانت عملها creation
+
+124
+00:10:50,130 --> 00:10:54,630
+من خلال الـ accept method أو الـ server socket
+
+125
+00:10:54,630 --> 00:10:59,090
+هدولتين هما المسؤولية عن مين؟ عن نقل البيانات بين
+
+126
+00:10:59,090 --> 00:11:03,680
+الـ client و بين الـ server وقولت كمان إن هاد الـ
+
+127
+00:11:03,680 --> 00:11:06,980
+connection صار على new port مختلف تمامًا عن الـ
+
+128
+00:11:06,980 --> 00:11:10,640
+port اللي بينعمل عليه listening عشان أتأكد أكثر
+
+129
+00:11:10,640 --> 00:11:13,500
+بدي أروح أضيف على الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+130
+00:11:13,500 --> 00:11:13,640
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+131
+00:11:13,640 --> 00:11:14,260
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+132
+00:11:14,260 --> 00:11:14,600
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+133
+00:11:14,600 --> 00:11:15,540
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+134
+00:11:15,540 --> 00:11:16,980
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+135
+00:11:16,980 --> 00:11:17,120
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+136
+00:11:17,120 --> 00:11:17,420
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+137
+00:11:17,420 --> 00:11:18,800
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+138
+00:11:18,800 --> 00:11:21,440
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ
+
+139
+00:11:21,440 --> 00:11:27,910
+الـ .. الـ .. العن الـ method accept هروح أقول له
+
+140
+00:11:27,910 --> 00:11:34,510
+هنا أنا الـ client.getPort هات لي الـ port الأصل أن 
+
+141
+00:11:34,510 --> 00:11:38,370
+الـ board هذا يطلع رقم مختلف عن رقم العشرين تلاتين
+
+142
+00:11:38,370 --> 00:11:41,730
+اللي أنا بعمل عليه لسنين هاي بدو يجي في ال running
+
+143
+00:11:41,730 --> 00:11:48,270
+applications شغل ال server side دخل في مرحلة ال
+
+144
+00:11:48,270 --> 00:11:55,580
+wet الآن هاي ال client وبده أشغله أول مرة هيو راح
+
+145
+00:11:55,580 --> 00:12:01,780
+جالي إيش؟ connection has been established on 57253
+
+146
+00:12:01,780 --> 00:12:06,080
+الـ board الآن ال connection أو ال data هتترسل ما
+
+147
+00:12:06,080 --> 00:12:12,260
+بين ال client و ال server عبر الـ board 57253 طيب
+
+148
+00:12:12,260 --> 00:12:16,020
+لو أنا عملت كمان new connection  الأصل ياخد
+
+149
+00:12:16,020 --> 00:12:18,480
+different board لأن الـ board ده already حجز
+
+150
+00:12:18,480 --> 00:12:23,600
+للاتصال بين ال client أول و ال server هي كمان مرة
+
+151
+00:12:23,600 --> 00:12:26,760
+بدي أشغله، هاي الـ server راح تقابلها كمان مرة الـ
+
+152
+00:12:26,760 --> 00:12:29,820
+new connection has been established على board جديد
+
+153
+00:12:29,820 --> 00:12:37,180
+رقمه 56 وهكذا كل ما أعمل connection جديد بال
+
+154
+00:12:37,180 --> 00:12:40,620
+accept هتعمل generate a new socket بـ different new
+
+155
+00:12:40,620 --> 00:12:44,280
+board وهتعمل ربط ما بين ال client و ال socket
+
+156
+00:12:44,280 --> 00:12:47,500
+الجديدة اللي موجودة عندها من أجل نقلة البيانات
+
+157
+00:12:48,670 --> 00:12:51,530
+واضحة الجزئية هي يا بنات وبالتالي server socket
+
+158
+00:12:51,530 --> 00:12:54,990
+عشان أعمل listening socket عند ال client بتعمل
+
+159
+00:12:54,990 --> 00:12:58,870
+request في الأول accept بتعمل generate لسكت جديدة
+
+160
+00:12:58,870 --> 00:13:02,570
+عند ال server side وبتربط الـ two ما اسمناها ال
+
+161
+00:13:02,570 --> 00:13:05,630
+socket هي عبارة عن end point connection بتربط ال
+
+162
+00:13:05,630 --> 00:13:07,990
+end point connection لـ client مع ال server عبر ال
+
+163
+00:13:07,990 --> 00:13:12,710
+board لجديد هذا وبتظل تعمل listening على الـ board
+
+164
+00:13:12,710 --> 00:13:15,500
+اللي موجود مع ال server socket طبعا هذه الجزئية
+
+165
+00:13:15,500 --> 00:13:19,000
+المفروض أن اضحكت ومافيش فيها أي مشاكل في حد فيها
+
+166
+00:13:19,000 --> 00:13:23,060
+عنده أي سؤال يبقى يناظر في هذا الموضوع؟ طبعا ننتقل
+
+167
+00:13:23,060 --> 00:13:28,460
+لجزئية نقل البيانات أنا الآن بدي أبدأ أرحل بيانات
+
+168
+00:13:28,460 --> 00:13:31,440
+قلت أنا الشغل التاني اللي بتهمني في ال connection
+
+169
+00:13:31,440 --> 00:13:34,040
+أو لما تكلمنا عن ال networking قلنا في ال
+
+170
+00:13:34,040 --> 00:13:37,700
+connection أو بالزمن أنا إيش الأربع شغلات الأساسية مع ال
+
+171
+00:13:37,700 --> 00:13:41,100
+socket أن أعمل connection وهي حققناها من خلال مين؟
+
+172
+00:13:41,100 --> 00:13:45,150
+من خلال كلمة socket، مصبوط؟ الثانية والثالثة أن
+
+173
+00:13:45,150 --> 00:13:48,590
+يعمل input أو send و receive send و receive ميناته
+
+174
+00:13:48,590 --> 00:13:53,450
+أن أنا بدي أعمل input stream و output stream كمان
+
+175
+00:13:53,450 --> 00:14:00,530
+الآن بدي 
+
+176
+00:14:00,530 --> 00:14:04,450
+أشتغل على ال buffer reader على سبيل المثال buffer
+
+177
+00:14:04,450 --> 00:14:08,450
+reader هيمثل 
+
+178
+00:14:08,450 --> 00:14:12,390
+input stream بظبط يساوي new
+
+179
+00:14:13,840 --> 00:14:18,080
+buffered reader الآن 
+
+180
+00:14:18,080 --> 00:14:25,060
+سابقا كنت ببدل ال buffer reader file input stream
+
+181
+00:14:25,060 --> 00:14:29,640
+تمام؟ أو file reader بس الآن هنا ال source تبع مش
+
+182
+00:14:29,640 --> 00:14:33,600
+file ال source تبع مش file ال source تبع مين؟ ال
+
+183
+00:14:33,600 --> 00:14:37,380
+socket ال socket هي عشان أجيب ال input stream
+
+184
+00:14:37,380 --> 00:14:41,860
+تبعتها لازم أعمل ال new input
+
+185
+00:14:44,060 --> 00:14:47,900
+stream reader بدي أعمل reader لازم أعمل reader و
+
+186
+00:14:47,900 --> 00:14:51,080
+ال reader هذا بده ينبني على ال socket الخاص بال
+
+187
+00:14:51,080 --> 00:15:00,240
+client dot get input stream كمان 
+
+188
+00:15:00,240 --> 00:15:06,100
+مرة خلينا بس هي كده نعمل الشاشة بشكل أفضل عشان
+
+189
+00:15:06,100 --> 00:15:08,720
+تكون كلها إيش جدا من الصدر
+
+190
+00:15:14,180 --> 00:15:25,960
+بقي كمان واحد تمام الآن هاد هيك 100% إيش اللي أنا
+
+191
+00:15:25,960 --> 00:15:29,360
+عاملًا بقى أسوي ال buffer reader بنيتها على input
+
+192
+00:15:29,360 --> 00:15:32,620
+reader input stream reader وال input stream reader
+
+193
+00:15:32,620 --> 00:15:37,130
+هاد ربطها بال socket input stream ربطها بالسكت
+
+194
+00:15:37,130 --> 00:15:41,290
+input stream يعني الآن هصير أتعامل مع ال input
+
+195
+00:15:41,290 --> 00:15:45,490
+stream مع السكت وكإني بقرأ من file ال buffer
+
+196
+00:15:45,490 --> 00:15:50,310
+reader فيها method read و read line مظبوط مش هدول
+
+197
+00:15:50,310 --> 00:15:53,090
+اللي شفناهم مع ال buffer reader الآن أنا ممكن
+
+198
+00:15:53,090 --> 00:15:57,010
+أستفيد منهم في القراءة من الملف كذلك لما أنا بدي
+
+199
+00:15:57,010 --> 00:16:03,250
+أكتب على السكت هاي بدي أعتمد على ال buffer writer
+
+200
+00:16:03,250 --> 00:16:04,370
+على سبيل المثال
+
+201
+00:16:09,920 --> 00:16:14,560
+عندي أسميها out buffered
+
+202
+00:16:14,560 --> 00:16:21,480
+writer بنفس الكيفية السابقة هيكون في عندي هنا new
+
+203
+00:16:21,480 --> 00:16:24,620
+output 
+
+204
+00:16:24,620 --> 00:16:29,600
+streamwriter وفي داخل ال input streamwriter ال
+
+205
+00:16:29,600 --> 00:16:33,380
+output streamwriter هقول لك ال socket تبعتي هي ال
+
+206
+00:16:33,380 --> 00:16:54,050
+client socket هي dot getoutput stream وبهيك
+
+207
+00:16:54,050 --> 00:16:58,510
+صار في عندي أنا وفي
+
+208
+00:16:58,510 --> 00:17:02,690
+عندي buffer reader و buffer writer على مين؟ على ال
+
+209
+00:17:02,690 --> 00:17:05,670
+socket الآن وقت إيش ال plane بكتب على ال socket
+
+210
+00:17:05,670 --> 00:17:09,510
+بقدر أقرأ من خلال مين؟ الـ buffer reader وانتهيش
+
+211
+00:17:09,510 --> 00:17:14,330
+للسر اللي بدي أكتبه أنا بكتب من خلال ال buffer
+
+212
+00:17:14,330 --> 00:17:20,530
+writer نفس الكود هذا تمام؟ بدي يكون وين؟ عند ال
+
+213
+00:17:20,530 --> 00:17:26,230
+client بس على ال socket اللي موجود عند ال client
+
+214
+00:17:26,230 --> 00:17:35,870
+نعيده مرة ثانية مافيش مشكلة buffer reader input
+
+215
+00:17:35,870 --> 00:17:41,010
+هتكون هيكون الـ NewBufferedReader والـ
+
+216
+00:17:41,010 --> 00:17:42,270
+BufferedReader هذه هنبنيها على
+
+217
+00:17:42,270 --> 00:17:47,990
+NewInputStreamReader
+
+218
+00:17:47,990 --> 00:17:51,470
+والـ InputStreamReader هتاخد الـ object اللي بخاصة
+
+219
+00:17:51,470 --> 00:17:58,950
+بالـ socket.getInputStreamBufferedWriter
+
+220
+00:17:58,950 --> 00:18:03,910
+بنفس الكيفية BufferedWriter out
+
+221
+00:18:05,430 --> 00:18:08,810
+New Buffered Writer الـ Buffered Writer هتتبني على
+
+222
+00:18:08,810 --> 00:18:15,030
+Output Stream Writer والـ
+
+223
+00:18:15,030 --> 00:18:18,770
+Output Stream Writer هتاخد الـ Constructor تبعتها
+
+224
+00:18:18,770 --> 00:18:24,230
+هياخد Input Stream أو Output Stream الخاصة
+
+225
+00:18:24,230 --> 00:18:29,410
+بالسوكيت اللي موجود عندي Dot Get Output Stream
+
+226
+00:18:29,410 --> 00:18:33,450
+تمام
+
+227
+00:18:33,450 --> 00:18:39,740
+أنا الآن كل اللي عملته بعد ما عرفت ال socket
+
+228
+00:18:39,740 --> 00:18:44,380
+تمام أنشأت عليها buffer reader و buffer writer لسه
+
+229
+00:18:44,380 --> 00:18:49,160
+أما كتبتش data طيب هل أنا إيش اللي بيصير بعد هيك
+
+230
+00:18:49,160 --> 00:18:51,820
+عملية قراءة أو كتابة من ال buffer مثل ما كنت
+
+231
+00:18:51,820 --> 00:18:55,140
+بتعاملي مع الملفات بالتمام ولا إيش هتختلف عندك ولا
+
+232
+00:18:55,140 --> 00:19:00,380
+إيش هيختلف عندك الآن إذا ال server أو عفوا إذا ال
+
+233
+00:19:00,380 --> 00:19:04,710
+client بدي يكتب في الأول هيروح على الـ out اللي هي
+
+234
+00:19:04,710 --> 00:19:12,130
+ال buffer writer مصبوط dot write إيش بكتب كتبي؟ 
+
+235
+00:19:12,130 --> 00:19:19,270
+hello thanks
+
+236
+00:19:19,270 --> 00:19:26,770
+for accepting my request على سبيل المثال
+
+237
+00:19:33,150 --> 00:19:38,270
+الآن هذا الـ buffer انكتب على مين أنت كتبت وين
+
+238
+00:19:38,270 --> 00:19:41,550
+كمان مرة على الـ buffered writer انكتب على الـ
+
+239
+00:19:41,550 --> 00:19:46,250
+socket ولا ما انكتبش أنت بتلزميه من خلال الـ
+
+240
+00:19:46,250 --> 00:19:51,190
+method اسمها flush تتذكروها بقول الـ flush
+
+241
+00:19:51,190 --> 00:19:55,350
+method بتجبر ال content اللي في ال buffer أن وين
+
+242
+00:19:55,350 --> 00:19:58,190
+يكتب على ال target تبعته مين ال target تبعته ال
+
+243
+00:19:58,190 --> 00:20:02,950
+socket؟ وما تنسيش أن ال socket الآن تبع ال server
+
+244
+00:20:02,950 --> 00:20:06,250
+side اللي نفترضها بإيدي اليمين وال client side
+
+245
+00:20:06,250 --> 00:20:09,210
+إيدي اليسار already connected مع بعض وبالتالي هما 
+
+246
+00:20:09,210 --> 00:20:13,910
+socket واحدة أصبحت فأنت بتكتبي لما تعمل flush
+
+247
+00:20:13,910 --> 00:20:15,710
+بتجيب من ال buffer اللي عندك في ال application
+
+248
+00:20:15,710 --> 00:20:18,750
+يكتب عليه ال socket واللي موجود في ال socket
+
+249
+00:20:18,750 --> 00:20:23,610
+already هنكتب أو يتاخد من ال socket الثانية طيب
+
+250
+00:20:23,610 --> 00:20:27,070
+تعالى نشوف ال server-side بده يقرأ عشان ال
+
+251
+00:20:27,070 --> 00:20:29,970
+server-side يقرأ ال content اللي موجودة في ال
+
+252
+00:20:29,970 --> 00:20:38,370
+socket هاي هروح أقول له string ال text أو str يساوي
+
+253
+00:20:38,370 --> 00:20:47,010
+input dot read line اه
+
+254
+00:20:47,010 --> 00:20:47,630
+بس okay
+
+255
+00:20:50,270 --> 00:20:53,970
+هذا الموضوع يبدو مشكلة بسيطة ولكن بحلها الآن
+
+256
+00:20:53,970 --> 00:20:59,150
+سأشغل هذا الموضوع وعشان أتأكد أن السيرفر طبعا أو
+
+257
+00:20:59,150 --> 00:21:02,250
+السيرفر قرأت ال text اللي موجود سأقول له ال
+
+258
+00:21:02,250 --> 00:21:11,050
+String dot to upper لكي أحولها كتلة لكرم هذه
+
+259
+00:21:11,050 --> 00:21:16,670
+السيرفر اشتغل ويعمل ال weighting هذه الشركة شغلت 
+
+260
+00:21:16,670 --> 00:21:22,460
+ال client إيش صار فيه عندي؟ صار فيه عندي exception
+
+261
+00:21:22,460 --> 00:21:25,980
+تمام وقال لي connection reset وقال لي في ال
+
+262
+00:21:25,980 --> 00:21:30,540
+buffered read line في مشكلة في سطر 28 على ال
+
+263
+00:21:30,540 --> 00:21:34,940
+server-side 28 على ال server-side السطر هذا السبب
+
+264
+00:21:34,940 --> 00:21:39,980
+.. السبب أن ال method اللي أنا استخدمتها right إيش
+
+265
+00:21:39,980 --> 00:21:44,620
+بتساوي؟ أخدت النص اللي موجودة وكتبته ال buffered
+
+266
+00:21:44,620 --> 00:21:48,980
+reader اللي أنا استخدمت إيش استخدمت؟ read line هل
+
+267
+00:21:48,980 --> 00:21:53,040
+في slash n عشان ينهي نهاية السطر؟ لأن ماعنديش
+
+268
+00:21:53,040 --> 00:21:57,340
+slash n طيب لو أنا قلت له يعني لو استبدلتها بـ read
+
+269
+00:21:57,340 --> 00:22:01,820
+بالميثود
+
+270
+00:22:01,820 --> 00:22:09,180
+التانية ال
+
+271
+00:22:09,180 --> 00:22:14,450
+read دي إيش بترجع؟ عمالة بترجع بـ integer وإذا
+
+272
+00:22:14,450 --> 00:22:18,130
+بتذكري كنت لما كنت بعمل ال while مع ال read بقول
+
+273
+00:22:18,130 --> 00:22:22,030
+له لا يساوي نقص واحد، مصبوط؟ ومع ال read line كلها
+
+274
+00:22:22,030 --> 00:22:26,150
+تساوي null، صح؟ وبالتالي أنا بروح أعملها casting
+
+275
+00:22:26,150 --> 00:22:29,230
+خلاص،
+
+276
+00:22:29,230 --> 00:22:34,250
+بنحلها، بنرجع ال text هنا read line زي ما كانت وكل
+
+277
+00:22:34,250 --> 00:22:39,180
+المطلوب مني هنا في ال code هذا أن أحط slash n عشان
+
+278
+00:22:39,180 --> 00:22:47,060
+يصل نهاية السطر ارجع مرة ثانية أشغل أروح أشغل ال
+
+279
+00:22:47,060 --> 00:22:52,380
+client لاحظي اشتغل مافيش فيه أي مشكلة وهي ال
+
+280
+00:22:52,380 --> 00:22:57,780
+server side طبع النص اللي وصله من وين من ال client 
+
+281
+00:22:57,780 --> 00:23:00,820
+واحنا في ال server side قولنا له حاولوا لمين ل
+
+282
+00:23:00,820 --> 00:23:04,840
+uppercase فطبع ليها هي uppercase hello thanks for
+
+283
+00:23:04,840 --> 00:23:11,020
+accepting my request وبالتالي ال data انتقلت طيب، 
+
+284
+00:23:11,020 --> 00:23:16,400
+الآن لو هذا ال client ال server ما زال شغال و بدي 
+
+285
+00:23:16,400 --> 00:23:19,140
+أعمل ال new client و أغير في ال text اللي موجود
+
+286
+00:23:19,140 --> 00:23:27,880
+ممكن؟ اه ممكن هي save و بس طبعت كلمة hello لحالها
+
+287
+00:23:27,880 --> 00:23:35,160
+شغلت ال client كمان مرة أخد جالهاي في connection
+
+288
+00:23:35,160 --> 00:23:40,300
+جديد استابلش على ال board هذا و بعت منه يعني أنه
+
+289
+00:23:40,300 --> 00:23:43,100
+الآن اللي بعد ال accept هيظل في ال way لحد ما ال
+
+290
+00:23:43,100 --> 00:23:46,440
+accept تأخذ new connection و نشتغل فيها تبعا
+
+291
+00:23:46,440 --> 00:23:52,360
+ممتاز طيب الآن لو بدي أعمل العكس لو أنا بدي أخلي
+
+292
+00:23:52,360 --> 00:23:55,900
+ال client أو ال server يكتب ال text هذا أو بلاش
+
+293
+00:23:55,900 --> 00:24:01,430
+يرد له بال length تبع ال text اللي موجودة في ال server
+
+294
+00:24:01,430 --> 00:24:04,210
+الآن طبعا لما بدي أعدل على السيرفر حتى لو أوقف
+
+295
+00:24:04,210 --> 00:24:07,550
+لما بدي أعدل على ال server لازم أوقف ال connection
+
+296
+00:24:07,550 --> 00:24:11,390
+اللي موجود عشان أشوف إيش اللي بيحصل لاحقا طيب خلصنا
+
+297
+00:24:11,390 --> 00:24:16,610
+الآن ال server بده يكتب عند ال client بده يكتب عدد
+
+298
+00:24:16,610 --> 00:24:21,950
+يحوله إياها و يرد له مثلا بالعدد تبعها هاي out
+
+299
+00:24:21,950 --> 00:24:26,210
+اللي هي output stream تبعتنا ال output writer dot
+
+300
+00:24:26,210 --> 00:24:33,360
+write أنا بدي أخد ال string هذا و أطبع له كما هو باس
+
+301
+00:24:33,360 --> 00:24:38,880
+كابيتال letter هي plus عشان أكتبه as a new line
+
+302
+00:24:38,880 --> 00:24:48,380
+هاي slash n تمام و بدي أطبع كمان و كمان سطر out
+
+303
+00:24:48,380 --> 00:24:56,380
+dot write ال str dot length بس
+
+304
+00:24:56,380 --> 00:25:00,040
+بدي أكتب له text string length
+
+305
+00:25:02,900 --> 00:25:11,540
+equal plus str.length plus ما تنسى slash n عشان
+
+306
+00:25:11,540 --> 00:25:16,920
+أنا أقرأها إيش كسطر ثاني و الآن هروح أخلي يعمل out
+
+307
+00:25:16,920 --> 00:25:24,900
+عشان أتأكد أنه كتب هقول out.flush الآن ال client
+
+308
+00:25:24,900 --> 00:25:29,620
+أو ال server كتب سطرين على ال socket ال server كتب
+
+309
+00:25:29,620 --> 00:25:35,030
+سطرين كتب ال text as uppercase تمام؟ و السطر الثاني
+
+310
+00:25:35,030 --> 00:25:37,330
+رجع بقى كتاب لل text الثاني مع ال length اللي
+
+311
+00:25:37,330 --> 00:25:44,230
+موجودة اه الآن لو أنا ما كتبتش flush أو بين جوسين
+
+312
+00:25:44,230 --> 00:25:48,770
+هل ضروري أنا أكتب ال flush؟ مش ضروري بس ما فيش ضامن
+
+313
+00:25:48,770 --> 00:25:54,220
+إن ال data انتقلت من ال buffer لل socket ما فيش ضعيف
+
+314
+00:25:54,220 --> 00:25:57,060
+من إن ال data انتقلت من ال buffer لسه سكت عشان
+
+315
+00:25:57,060 --> 00:26:00,920
+أنا أضمن عملت الكتابة تمت لازم أعمل flush خلينا
+
+316
+00:26:00,920 --> 00:26:05,520
+نشغل بدون ال flush و نشوف شيء ما بيصير هل أنت مانت
+
+317
+00:26:05,520 --> 00:26:06,300
+مانت مانت مانت مانت مانت مانت مانت مانت مانت مانت
+
+318
+00:26:06,300 --> 00:26:12,280
+مانت مانت مانت
+
+319
+00:26:12,280 --> 00:26:16,700
+مانت
+
+320
+00:26:16,700 --> 00:26:20,680
+تمام
+
+321
+00:26:20,680 --> 00:26:22,620
+شغلت
+
+322
+00:26:28,250 --> 00:26:32,810
+لحظة أنا على مستوى ال client ما قرأت النص اللي 
+
+323
+00:26:32,810 --> 00:26:35,910
+كتبه ال client، ال server، مظبوط؟ خليني الآن بدي
+
+324
+00:26:35,910 --> 00:26:41,730
+أقرأه، هاي ال string اللي سميها ال data، دعنا
+
+325
+00:26:41,730 --> 00:26:48,570
+نسميه مثلا N dot read line، لحظة شوية، بس واحدة
+
+326
+00:26:48,570 --> 00:26:54,070
+واحدة، ال read line هذه إيش هتساوي؟ هتقبل أول سطر
+
+327
+00:26:57,330 --> 00:27:04,050
+100% هيرن؟ هيه قرأ ليه أول سطر؟ شفتي؟ ما قراهوش،
+
+328
+00:27:04,050 --> 00:27:07,230
+ما كتبهوش؟
+
+329
+00:27:07,230 --> 00:27:10,850
+ما كتبهوش؟ ال client ما كتبش ولا حاجة أو خليني ننتقل
+
+330
+00:27:10,850 --> 00:27:14,770
+لـ client فن ما كتبش ولا شيء، ليش؟ لأن أنا مش ضامن
+
+331
+00:27:14,770 --> 00:27:17,710
+إن ال flush فعليا كتبت ولا ما كتبتش، بس هذه الفكرة
+
+332
+00:27:17,710 --> 00:27:21,410
+عشان اللي قلت لك ما فيش ضامن لعملية الكتابة هو الأصل
+
+333
+00:27:21,410 --> 00:27:24,830
+الآن إن بعد ما أكتب أعمل close لأن خلصت من ال
+
+334
+00:27:24,830 --> 00:27:29,700
+socket ال close فيها auto flush بس أنا ما بديش أعمل
+
+335
+00:27:29,700 --> 00:27:31,700
+ال close بس أنا ما بدي أكتب مرة ثانية و ثالثة و
+
+336
+00:27:31,700 --> 00:27:33,440
+رابعة على نفسي ال software بتالة مش لازم أعملها
+
+337
+00:27:33,440 --> 00:27:41,260
+close هرجع عند ال server أفعل ال flush أشغل
+
+338
+00:27:41,260 --> 00:27:46,020
+من جديد شغلت ال server أروح على ال client هي run
+
+339
+00:27:46,020 --> 00:27:49,380
+okay
+
+340
+00:27:49,380 --> 00:27:55,080
+ما طبعش هنا خطأ
+
+341
+00:27:59,180 --> 00:28:02,920
+لأ هي طبعا okay بس دلت ال console الخاصة بال
+
+342
+00:28:02,920 --> 00:28:06,260
+server هي اللي قدامي أنا عمال يبقى اتقال هيها شوف
+
+343
+00:28:06,260 --> 00:28:10,800
+البنات هي شاشة ال server لأ ما فيش عليها حاجة لما
+
+344
+00:28:10,800 --> 00:28:13,360
+اتقالت لل console قبل شوية كانت فاضية لأ هي كاتب
+
+345
+00:28:13,360 --> 00:28:18,440
+بس كاتب سطر طبعا الحل أترق السطر الثاني ماشي الحل
+
+346
+00:28:18,440 --> 00:28:27,760
+okay يعني أنت قاعد بتقولي أعمل هيك كمان مرة بس
+
+347
+00:28:27,760 --> 00:28:34,110
+بدون تعريف ال data هي ران لـ client هاي جاب ليها طب
+
+348
+00:28:34,110 --> 00:28:38,210
+لو ال server كان بيقرأ من ملف و بيكتب على ال socket
+
+349
+00:28:38,210 --> 00:28:45,530
+بدي أعمل ال while loop لازم أعمل ال while loop
+
+350
+00:28:45,530 --> 00:28:50,900
+واضح لحد اللحظة تمام؟ كمان مرة أنا اللي قاعد بقى
+
+351
+00:28:50,900 --> 00:28:54,360
+أقوله هاي ال server راح يكتب تلت أسطر أو سطرين
+
+352
+00:28:54,360 --> 00:28:58,700
+مختلفات على ال socket عاجب .. جملتين بقدر أروح
+
+353
+00:28:58,700 --> 00:29:02,840
+أكتب مرتين أو أقرأ مرتين لأن أنا عارف كتب two line
+
+354
+00:29:02,840 --> 00:29:06,200
+لكن لو كان في line .. في .. بيقرأ .. بي .. عفوا
+
+355
+00:29:06,200 --> 00:29:09,760
+المفروض أن ال server الآن يقرأ ملف أنا بقى ما أعرفش
+
+356
+00:29:09,760 --> 00:29:13,740
+حجمه و بيقرأ سطر سطر و السطر اللي بيقرأه بيكتب
+
+357
+00:29:13,740 --> 00:29:22,000
+وين؟ بالكتب اللي هي على ال socket ماذا سأفعل؟ أقرأ
+
+358
+00:29:22,000 --> 00:29:36,180
+اللوب الخاص بي خليني أكتب كمان كمان سطر ال
+
+359
+00:29:36,180 --> 00:29:41,220
+new string و 
+
+360
+00:29:41,220 --> 00:29:42,740
+أحتفظ بس بال connection هذه
+
+361
+00:29:47,530 --> 00:29:51,170
+تمام، هيك صارت ال server بدي أكتب three lines
+
+362
+00:29:51,170 --> 00:29:57,710
+three different lines تمام الآن لما أنا بدي أعمل
+
+363
+00:29:57,710 --> 00:30:03,670
+loop عشان أنا أرتاح من هدول إيش المفروض أساوي؟
+
+364
+00:30:03,670 --> 00:30:07,310
+جاب لي ال why تتذكروا كيف كنا نقرأ من ال buffer
+
+365
+00:30:07,310 --> 00:30:16,190
+reader؟ كنا نقول له عفوا while ال
+
+366
+00:30:16,190 --> 00:30:24,180
+line يساوي ال input أو ال buffer الريدر dot read
+
+367
+00:30:24,180 --> 00:30:32,840
+line هذا لا يساوي null صح طالما هو لا يساوي null
+
+368
+00:30:32,840 --> 00:30:36,880
+كنت أروح أجمعه في ال data و كنت أنا من البداية كنت 
+
+369
+00:30:36,880 --> 00:30:45,660
+معرف string line equal فاضي صح و بعرف string بتجمع
+
+370
+00:30:45,660 --> 00:30:48,840
+عليه كل ال data هاي كمان string
+
+371
+00:30:52,080 --> 00:31:01,660
+Served Data أو SRV Data برضه تساوي فاضية والآن
+
+372
+00:31:01,660 --> 00:31:06,780
+طالما أن في أسطر موجودة في ال socket أو في ال 
+
+373
+00:31:06,780 --> 00:31:09,800
+buffered reader اللي عندي اقرأ ليهم سطر ورا الثاني
+
+374
+00:31:09,800 --> 00:31:19,980
+بظبط هروح أقول له أنا Served Data plus equal
+
+375
+00:31:21,610 --> 00:31:25,590
+ال line plus slash n عشان أحافظ إن كل سطر ينكتب
+
+376
+00:31:25,590 --> 00:31:35,510
+بشكل مستقل أظبط؟ و في الآخر بدي أروح أطبع ال
+
+377
+00:31:35,510 --> 00:31:40,170
+serve data كمان
+
+378
+00:31:40,170 --> 00:31:44,830
+مرة يا بنات هذه ال slash n أنا بأضيفها لأن ال
+
+379
+00:31:44,830 --> 00:31:47,810
+slash n مش هتطلع مع ال line اللي فوق مع هذا ال
+
+380
+00:31:47,810 --> 00:31:52,930
+line هتقرأ كل نص اللي جاب لي ال line صح؟ و بالتالي
+
+381
+00:31:52,930 --> 00:31:56,270
+أنا الآن بدي أشتغل بالمنطق هذا بدي أطبع لهم أسطر
+
+382
+00:31:56,270 --> 00:31:58,950
+تلت أسطر ورا بعض ما فيش عندي مشكلة بقى أضيف ال line
+
+383
+00:31:58,950 --> 00:32:03,850
+اللي موجودة عندي save أروح أشغل ال server ال
+
+384
+00:32:03,850 --> 00:32:05,910
+server waiting for a new request إنه new
+
+385
+00:32:05,910 --> 00:32:11,850
+connection شغلت ال client أروح
+
+386
+00:32:11,850 --> 00:32:12,650
+على ال client side
+
+387
+00:32:19,050 --> 00:32:25,150
+ما قرأش؟ ما دعمش ولا شيء؟
+
+388
+00:32:25,150 --> 00:32:34,730
+okay إيش في خطأ عندنا هنا؟ request طيب قعدوا أذنكم 
+
+389
+00:32:34,730 --> 00:32:40,730
+أنا بدي أقرأ أول سطر بس أتأكد أن الأمور تمام اللي 
+
+390
+00:32:40,730 --> 00:32:48,370
+هي ال in dot read line هيك بيظل سطرين
+
+391
+00:33:12,310 --> 00:33:15,490
+السطر الأول مصبوخ قبل ما يدخل في اللوب
+
+392
+00:33:28,040 --> 00:33:32,680
+و معناه هيك الكلام إنه اعتبر إنه Hades هو اتنال من
+
+393
+00:33:32,680 --> 00:33:33,740
+البداية
+
+394
+00:34:01,050 --> 00:34:04,650
+ال server ما زال شغال تمام، هيك بس عندنا ولا 
+
+395
+00:34:04,650 --> 00:34:16,290
+application للسيرفر، لا حول ولا قوة خليني
+
+396
+00:34:16,290 --> 00:34:17,050
+هاد هيك
+
+397
+00:34:31,200 --> 00:34:35,000
+readline readline readline جابهم 100% عدوا في ال
+
+398
+00:34:35,000 --> 00:34:41,360
+loop كان فيه مشكلة إن ال condition تبعتنا هي ما
+
+399
+00:34:41,360 --> 00:34:48,220
+اعتبرتهاش صحيحة طيب دعوني أشوف مشكلة ال loop اللي
+
+400
+00:34:48,220 --> 00:34:55,960
+عندنا هنا germinate
+
+401
+00:35:03,430 --> 00:35:07,710
+Okay تعال نشوف إيش فيه مشكلة في اللوب هنا سيرف
+
+402
+00:35:07,710 --> 00:35:13,490
+داتا يعني هو فعليا ما دخلش على اللوب اللي موجودة
+
+403
+00:35:13,490 --> 00:35:20,470
+عندي هنا scroll console clear نعم
+
+404
+00:35:32,980 --> 00:35:48,000
+debug as java application yes داخل
+
+405
+00:35:48,000 --> 00:35:50,920
+ال Y لحظة جملة جهة الطباعة ما دخلش ال Y المطلق
+
+406
+00:35:50,920 --> 00:35:56,960
+هنا يا أستاذ لو دخل لجهة قيمة ال data مش مشكلة هلأ 
+
+407
+00:35:56,960 --> 00:36:00,580
+بنحط جملة طباعة جوة هنا okay
+
+408
+00:36:16,200 --> 00:36:22,520
+ال server ما زال شغال تمام ال client أنا بدي أوقفه
+
+409
+00:36:22,520 --> 00:36:24,960
+بشغله كمان مرة
+
+410
+00:36:32,520 --> 00:36:37,940
+أولا، كونه طبع تلت مرات ما شاف ال text فعلا three
+
+411
+00:36:37,940 --> 00:36:43,780
+lines طيب طيب أنا بدي أروح أقول له اطبع لي ال line،
+
+412
+00:36:43,780 --> 00:36:48,500
+ما بديش تطبع لي test علشان بس أعرف، لأن الصحيح مش
+
+413
+00:36:48,500 --> 00:36:55,880
+شايف إن قدامي خطأ هاي كمان مرة هاي،
+
+414
+00:36:55,880 --> 00:36:59,960
+جاب؟ طب جملة ال concatenate دي هي خطأ؟
+
+415
+00:37:03,430 --> 00:37:13,730
+لحظة إنه قرأ السطر و جمعه صح ما فيش فيه مشكلة يعني 
+
+416
+00:37:13,730 --> 00:37:19,610
+بس المشكلة إحنا
+
+417
+00:37:19,610 --> 00:37:24,290
+بالطبع ما كناش نعرف الأسنان يعني نعم كنا كنا كنا
+
+418
+00:37:24,290 --> 00:37:31,130
+كنا كنا كنا
+
+419
+00:37:31,130 --> 00:37:34,510
+كنا كنا كنا كنا كنا كنا كنا كنا كنا كنا كنا الآن
+
+420
+00:37:34,510 --> 00:37:39,630
+shared data الله 
+
+421
+00:37:39,630 --> 00:37:44,350
+أكبر يعني حد جماعة الخير يقول إيه هو الخطأ أنا مش
+
+422
+00:37:44,350 --> 00:37:51,510
+قادر أمسكه الصحيحة يعني هاي بطبع الـ line ترميت
+
+423
+00:37:51,510 --> 00:37:57,650
+تمام هاي طبع الـ line 100% هاي الـ line طبعها جملة
+
+424
+00:37:57,650 --> 00:38:12,450
+طبعها جوا اللي هو غلط هذه اللوحة كانت تبع غلط، تنفعش 
+
+425
+00:38:23,760 --> 00:38:27,420
+بنفعش أضيف كله على سطر واحد، على الـ string واحد،
+
+426
+00:38:27,420 --> 00:38:32,360
+لأن هيك هيصير يحتفظ بس في آخر سطر، فأنا بدي كل الـ
+
+427
+00:38:32,360 --> 00:38:35,700
+texts فلازم يكون accumulative، تراكمي، أجمعه، و
+
+428
+00:38:35,700 --> 00:38:38,320
+تراكمي بالـ text .. بالـ code اللي أنا كاتبه هنا
+
+429
+00:38:53,370 --> 00:39:01,630
+جملة الطباعة كلها موصلهاش جملة
+
+430
+00:39:01,630 --> 00:39:06,190
+الطباعة كلها موصلهاش يعني و كانوا بقال شغالين في
+
+431
+00:39:06,190 --> 00:39:13,610
+اللوغ طيب هي out.close
+
+432
+00:39:50,280 --> 00:39:52,640
+Okay لأن السيرفر اضفها لا حاجة ولا غلط
+
+433
+00:40:10,900 --> 00:40:14,460
+الآن احنا فعليا خلصنا ما فيش فيها مشكلة لا في الـ
+
+434
+00:40:14,460 --> 00:40:17,740
+loop ولا كده بس في خطأ مش قادرين نحط إيدينا عليه أو
+
+435
+00:40:17,740 --> 00:40:22,580
+إيش مشكلته هلجت من هنا أو ممكن نخلص للمرة الجاية
+
+436
+00:40:22,580 --> 00:40:26,980
+بنزلكوا الـ code شغال على الأقل أحاول أو أعرف وين
+
+437
+00:40:26,980 --> 00:40:28,620
+الخطأ اللي موجود معانيه اللي مش قادرين نحط إيدينا
+
+438
+00:40:28,620 --> 00:40:36,020
+عليه حد فيكم شايف خطأ يا جماعة الخير؟ الخطأ في الـ
+
+439
+00:40:36,020 --> 00:40:43,300
+connection هاي لأن هاي شوف إيه آه آه آه طيب عشان
+
+440
+00:40:43,300 --> 00:40:47,380
+أنا أنهي بدي أروح أشتغل بالطريقة التقليدية جدا الـ
+
+441
+00:40:47,380 --> 00:40:54,460
+serve plus ما هي اللي كنت بدي أشتغل؟ serve data
+
+442
+00:40:54,460 --> 00:41:05,300
+plus line برضه
+
+443
+00:41:05,300 --> 00:41:10,680
+لأ anyway يعني هو مش .. الفكرة كيف؟ماطبعهاش آه 
+
+444
+00:41:10,680 --> 00:41:15,100
+anyway أحاول
+
+445
+00:41:15,100 --> 00:41:21,740
+على قوة اللي أقولها serve data آخر محاولة
+
+446
+00:41:26,610 --> 00:41:30,910
+طبعًا حاش في شغلة غلط ومش راضي تجمع أو تجمع الـ text
+
+447
+00:41:30,910 --> 00:41:34,450
+لو رجعتي لشغل الـ files هتلاقي إن الـ code شغال 100%
+
+448
+00:41:34,450 --> 00:41:38,970
+على كل حال من ناحية الـ socket و تنقل بيانات ما بين
+
+449
+00:41:38,970 --> 00:41:40,130
+الـ client و الـ server
+
+450
+00:41:57,940 --> 00:42:03,600
+مهمش اشتغلوا كمان مرة الـ client connection
+
+451
+00:42:03,600 --> 00:42:09,740
+refused احنا على كله نخلص وجهتنا كمان الاخر run هي
+
+452
+00:42:09,740 --> 00:42:18,180
+waiting هي الـ client run هذا الآن عند الـ client بس
+
+453
+00:42:18,180 --> 00:42:19,940
+ليش رجع طبع إيه طبع
+
+454
+00:42:30,170 --> 00:42:37,010
+سيرفر ريسبونس هاي هان عشان احنا نطبع هان
+
+455
+00:42:37,010 --> 00:42:45,470
+إيران سيرفر 
+
+456
+00:42:45,470 --> 00:42:53,650
+ريسبونس هاي هان طيب و هدول من وين جوا؟ طيب الله
+
+457
+00:42:53,650 --> 00:42:57,010
+يعطيكوا العافية و هو يا أنا يا الجهاز اللي فيه
+
+458
+00:42:57,010 --> 00:42:59,010
+مشكلة اليوم الله يعطيكوا العافية لهيك احنا من
+
+459
+00:42:59,010 --> 00:43:01,790
+ناحية شبكات أمورنا تمام إن شاء الله تبارك وتعالى و
+
+460
+00:43:01,790 --> 00:43:03,870
+نشوفكوا إن شاء الله في المحاضرة الجاية و نتكلم عن
+
+461
+00:43:03,870 --> 00:43:05,930
+الـ multi-threading الله يعطيكوا العافية بنات 
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/muf2InMW-gw_postprocess.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/muf2InMW-gw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..11a494947b824865d86c969bb43ea3d5d278eed1
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/muf2InMW-gw_postprocess.srt
@@ -0,0 +1,2056 @@
+1
+00:00:20,920 --> 00:00:22,940
+بسم الله الرحمن الرحيم الحمد لله والصلاة والسلام
+
+2
+00:00:22,940 --> 00:00:26,300
+على رسولنا اليوم ان شاء الله هنبدأ بأول موضوع في
+
+3
+00:00:26,300 --> 00:00:28,840
+الـ advanced programming بالنسبالنا بعد ال object
+
+4
+00:00:28,840 --> 00:00:33,060
+oriented ال exception handling أو معالجة الأخطاء
+
+5
+00:00:33,060 --> 00:00:37,900
+لما أنا بتكلم أو المصطلح exception قاعد باتكلم على
+
+6
+00:00:37,900 --> 00:00:42,560
+إشارة على إنه صار في عندي مشكلةأثناء تنفيذ
+
+7
+00:00:42,560 --> 00:00:46,840
+البرنامج أو احنا بنسميها أحيانا ال run-time error
+
+8
+00:00:46,840 --> 00:00:50,660
+يعني أنا قاعد بأتكلم أن الخطأ هذا بعيد عن ال
+
+9
+00:00:50,660 --> 00:00:55,260
+syntax code يعني أنت كتبت ال code تبعك و ال
+
+10
+00:00:55,260 --> 00:00:59,100
+compiler قالك ال code صحيح 100% اروح نعمل
+
+11
+00:00:59,100 --> 00:01:03,480
+execution تنفيذ هذا البرنامج أثناء ال run صار في
+
+12
+00:01:03,480 --> 00:01:08,880
+عندي مشكلة في البرنامج ووقف البرنامج طبعا لما أنا
+
+13
+00:01:08,880 --> 00:01:14,840
+بجي بتكلم exceptionمعناته بالعربي استثناء الحالة
+
+14
+00:01:14,840 --> 00:01:17,580
+اللي صارت هذه مش هي الحالة الأساسية تبع برنامجك
+
+15
+00:01:17,580 --> 00:01:21,520
+والدليل أنه كان من ناحية code تمام ال exception
+
+16
+00:01:21,520 --> 00:01:26,440
+هذه إما مفادها خطأ منطقي في تنفيذ ال code تبعك و
+
+17
+00:01:26,440 --> 00:01:30,260
+طبعا قلنا compiler مش هتيجي لكن في الآخر هي
+
+18
+00:01:30,260 --> 00:01:34,560
+المفروض infrequent error الخطأ هذا مش هيظهر كل مرة
+
+19
+00:01:34,560 --> 00:01:43,230
+الخطأ هذا مش هيظهر كل مرة طيب الآنلما انا اتكلم
+
+20
+00:01:43,230 --> 00:01:46,950
+على exception handling معناته البرنامج بيقدر يكمل
+
+21
+00:01:46,950 --> 00:01:51,210
+بعد ما اتصار الخطأ يعني في الوضع الطبيعي في الوضع
+
+22
+00:01:51,210 --> 00:01:54,830
+الطبيعي اي exception بيظهر في ال run-time run-time
+
+23
+00:01:54,830 --> 00:01:58,940
+error يعني البرنامج بده يقفالبرنامج بدي يقف لكن لو
+
+24
+00:01:58,940 --> 00:02:02,800
+أنا فعليا مهيئ برنامجي انه يتعامل مع الأخطاء او
+
+25
+00:02:02,800 --> 00:02:05,580
+يتعامل مع ال exception او الاستثناءات اللي بدها
+
+26
+00:02:05,580 --> 00:02:09,520
+تصير في ال one-time ومجهز نفسي ايش اللي ممكن يطلع
+
+27
+00:02:09,520 --> 00:02:13,780
+بقدر اتحكم في برنامجي واخلي برنامجي يظل شغال اخلي
+
+28
+00:02:13,780 --> 00:02:17,560
+برنامجي يظلشغّال طبعا طبعا البرنامج اللي احنا
+
+29
+00:02:17,560 --> 00:02:21,700
+بنقول عنها robust او fault tolerant programs هي
+
+30
+00:02:21,700 --> 00:02:26,380
+برنامج قوية برنامج قوية او مضمونة نركز عليها بحيث
+
+31
+00:02:26,380 --> 00:02:30,640
+انه تقدر تتعامل مع الأخطاء في ال run-time لو صارت
+
+32
+00:02:30,640 --> 00:02:35,260
+برجع و بأكد لو ال code free احنا بنتكلم على free
+
+33
+00:02:35,260 --> 00:02:39,300
+error طبعا run-time error أثناء التنفيذ صار في خطأ
+
+34
+00:02:39,300 --> 00:02:42,320
+في التنفيذ مش في البرنامج لأن لو في خطأ في ال code
+
+35
+00:02:44,160 --> 00:02:46,860
+هيكون compilation error وبالتالي البرنامج مش هيشغل
+
+36
+00:02:46,860 --> 00:02:54,880
+أساساً ال exception are thrown عادة لما بنجي نتكلم
+
+37
+00:02:54,880 --> 00:02:59,900
+على ال Java program بالتحديد هي في عندي ال Java
+
+38
+00:02:59,900 --> 00:03:06,880
+code اللاير الأولى وهنا انت مسئوليتك في عندي ال
+
+39
+00:03:06,880 --> 00:03:11,860
+Java virtual machine هذا اللاير التانيوهذا ليس
+
+40
+00:03:11,860 --> 00:03:15,400
+مسئوليتك بالمرة وفي عندك الـ Operating System
+
+41
+00:03:15,400 --> 00:03:19,820
+وبرضه هذا ليس من مسئوليتنا، تمام؟ الخطأ في الـ
+
+42
+00:03:19,820 --> 00:03:22,900
+Runtime On بيصير طبعا بعد ما احنا عملنا
+
+43
+00:03:22,900 --> 00:03:26,420
+compilation وكان صحيح 100% الآن الـ Java Virtual
+
+44
+00:03:26,420 --> 00:03:30,760
+Machine بتمسك البرنامج بتحوله للغة القالة وبتقول
+
+45
+00:03:30,760 --> 00:03:33,060
+ال Operating System اتفضل بما يفهمه ال Operating
+
+46
+00:03:33,060 --> 00:03:39,260
+System الآن أثناء التنفيذ لو صار في عندي خطأالـ
+
+47
+00:03:39,260 --> 00:03:42,640
+Java Virtual Machine قبل ما تاخد قرار إنها تعمل
+
+48
+00:03:42,640 --> 00:03:48,020
+Terminator للـ Application بتروح تعديني إشعار إنه
+
+49
+00:03:48,020 --> 00:03:51,840
+صار فيه خطأ يعني بترجع للبرنامج تبعي في الـ
+
+50
+00:03:51,840 --> 00:03:55,820
+Runtime إشعار إنه صار فيه خطأ معين الآن الإشعار
+
+51
+00:03:55,820 --> 00:04:01,410
+هذا إذا برنامجي جاهز يستقبلهويحلله وياخد action
+
+52
+00:04:01,410 --> 00:04:06,010
+تبعا له بيكمل الشغل الإشعار هذا بعتتلي ال Java
+
+53
+00:04:06,010 --> 00:04:10,010
+Virtual Machine وانا ماردتش عليه او مستلمتهش
+
+54
+00:04:10,010 --> 00:04:14,190
+الفاضي الحل ان ال Java Virtual Machine هتروح تعمل
+
+55
+00:04:14,190 --> 00:04:17,530
+terminate لل application تبعتنا واضح السيناريو
+
+56
+00:04:17,530 --> 00:04:23,960
+عندما تبعت ال Java Virtual Machine الإشعارأخلق ..
+
+57
+00:04:23,960 --> 00:04:25,900
+هو .. هو .. وين صار الخطأ؟ صار الخطأ عند الـ
+
+58
+00:04:25,900 --> 00:04:28,200
+Operating System لأن الـ Execution .. الـ
+
+59
+00:04:28,200 --> 00:04:30,740
+Execution هان الآن الـ Execution .. ال .. ال
+
+60
+00:04:30,740 --> 00:04:33,040
+Operating System قال فيه مشكلة الـ Java Virtual
+
+61
+00:04:33,040 --> 00:04:35,700
+Machine ردتها للـ Application تبعي هل الـ
+
+62
+00:04:35,700 --> 00:04:39,160
+Application الآن قادر يتعامل مع الإشعار .. إشعار
+
+63
+00:04:39,160 --> 00:04:42,340
+الخطأ هذا ولا لأ؟ بين جسين، جادر ياخد decision
+
+64
+00:04:42,340 --> 00:04:47,640
+ويكمل؟إذا أنا مش مهيئه إذا أنا مش مهيئه فبالتالي
+
+65
+00:04:47,640 --> 00:04:51,800
+الـ java virtual machine هتعمل terminate هتقول لل
+
+66
+00:04:51,800 --> 00:04:55,260
+operating system terminated خلاص أنا مابقدرش أعمل
+
+67
+00:04:55,260 --> 00:04:58,100
+response مع ال action أو مع الحدث اللي صار
+
+68
+00:05:01,050 --> 00:05:04,410
+استلام الإشعار ومعالجة الـ exception هذه مسئولية
+
+69
+00:05:04,410 --> 00:05:08,990
+من؟ مسئوليتك أنت كـ developer مسئوليتك أنت كـ
+
+70
+00:05:08,990 --> 00:05:13,450
+developer لماذا؟ لأن المفروض أنك أكثر واحد بيعرف
+
+71
+00:05:13,450 --> 00:05:18,110
+خبايا البرنامج يعني و بنقول بالمثال البسيط أنك لما
+
+72
+00:05:18,110 --> 00:05:21,650
+تروح تريد أن تسلمي assignment للأستاذ أو للمحاضرة
+
+73
+00:05:21,650 --> 00:05:26,590
+بغض النظر و أنت تكون عارف هل البرنامج شغال 100% و
+
+74
+00:05:26,590 --> 00:05:31,200
+لا نص نصليش؟ لأنك انت الكاتبان أو انت اللي جايبها
+
+75
+00:05:31,200 --> 00:05:33,380
+من زميلتك أو اللي انت جايبها من النت او او الاخري
+
+76
+00:05:33,380 --> 00:05:36,960
+بسوط انا لأ و بالتالي .. بالتالي انت اكثر واحدة
+
+77
+00:05:36,960 --> 00:05:43,740
+تفهم البرنامج هذا صح و عارفة وين خبايا الآن اضربت
+
+78
+00:05:43,740 --> 00:05:46,860
+مثال عند الشباب قبل شوية في مصانع أو في تصنيع
+
+79
+00:05:46,860 --> 00:05:50,600
+السيارات تصنيع السيارات عندهم ال trends او نسميهم
+
+80
+00:05:50,600 --> 00:05:55,650
+التوجهات حسب الأسواقيعني السيارة اللي تتصمم
+
+81
+00:05:55,650 --> 00:05:59,610
+لأوروبا غير السيارة اللي تتصمم للشرق الأوسط تمام
+
+82
+00:05:59,610 --> 00:06:02,410
+السيارة اللي مثلا اللي في مصر ممكن تكون غير
+
+83
+00:06:02,410 --> 00:06:07,090
+السيارة اللي تتصمم للسعودية ليش؟ لأننا نتكلم على
+
+84
+00:06:07,090 --> 00:06:10,950
+أجواء حارة أو أجواء مختلفة حتى الطرق ممكن تكون
+
+85
+00:06:10,950 --> 00:06:15,910
+مختلفة وبالتالي صاحق أو مصنع السيارة عامل حسابه
+
+86
+00:06:15,910 --> 00:06:19,130
+لكل التفاصيل هذه نظام التبريد بالسيارة نظام
+
+87
+00:06:19,130 --> 00:06:22,900
+العدلات المستخدم إلى آخر كل الشغلات هذهفبنفعش أنا
+
+88
+00:06:22,900 --> 00:06:25,680
+أجي في لحظة من اللحظات كإيد الشامي أقول والله
+
+89
+00:06:25,680 --> 00:06:30,720
+السيارة السيارة المفروض المصنعة لبلد للسويد بيدورح
+
+90
+00:06:30,720 --> 00:06:36,140
+أجيبها و أشغلها عندها في غزة ليش؟ لأن أجواء غزة لا
+
+91
+00:06:36,140 --> 00:06:40,060
+تتلقم أو مبردات السيارة أو مواصفات السيارة لا
+
+92
+00:06:40,060 --> 00:06:43,180
+تتلقم مع طبيعة الأجواء اللي أنا جايبها مين اللي
+
+93
+00:06:43,180 --> 00:06:46,980
+بيقدر ياخد decision يقول ليه بينفع ولا بينفعش؟اللي
+
+94
+00:06:46,980 --> 00:06:51,880
+صنعها لأنه عارف كل شغلة بتمشي ولا بتمشيش طيب، احنا
+
+95
+00:06:51,880 --> 00:06:54,860
+هالنفس الكلام انت اللي مسؤول عنه البرنامج هذا
+
+96
+00:06:54,860 --> 00:06:59,620
+الالترون هذا أو الإشعار اللي بديجيكي بالـ
+
+97
+00:06:59,620 --> 00:07:04,280
+exception اللي صار فيه معلومات كمان بنسميها احنا
+
+98
+00:07:04,280 --> 00:07:08,820
+stack trace فيه معلومات معلومات عن إيش؟ عن ال
+
+99
+00:07:08,820 --> 00:07:11,900
+exception إيش سبب الخطأ هذا؟ إيش هو الخطأ؟ وإيش
+
+100
+00:07:11,900 --> 00:07:15,660
+سببه؟ وأي سطر في ال code اتسبب بالخطأ اللي موجود
+
+101
+00:07:15,660 --> 00:07:20,860
+عندهم؟من المعلومات هذه أن name of exception اسم
+
+102
+00:07:20,860 --> 00:07:23,280
+الخطأ يعني الأخطاء اللي بتصير في ال run-time
+
+103
+00:07:23,280 --> 00:07:30,120
+معروفة معروفة أشي تكون هنا وفي نفس الوجهة بتديني
+
+104
+00:07:30,120 --> 00:07:35,480
+ال method call stack أنا الآن طبيعت برنامجي ممكن
+
+105
+00:07:35,480 --> 00:07:37,720
+يكون بيعتمد method على method على method يعني
+
+106
+00:07:37,720 --> 00:07:43,280
+بيعمل callingمن ضمن الـ stack trace هذه المعلومات
+
+107
+00:07:43,280 --> 00:07:46,380
+كل الـ method والاستدعاءات تبعتها بالـ Hierarchy
+
+108
+00:07:46,380 --> 00:07:51,780
+اللي صارت اللي نسميها ال stack الكلت stack لحد ما
+
+109
+00:07:51,780 --> 00:07:55,800
+يوصلني لـ method الأخيرة في السطر الفلاني صار في
+
+110
+00:07:55,800 --> 00:07:59,980
+عندي خطأ و هنشوف عندنا مثال عملية مع بعض وبالتالي
+
+111
+00:07:59,980 --> 00:08:04,260
+أنا بقدر استفيد مباشرة بشكل كويس من الـ throne أو
+
+112
+00:08:04,260 --> 00:08:07,940
+من الإشعار اللي بيوصلني عشان أتعامل مع الأخطاء
+
+113
+00:08:07,940 --> 00:08:11,900
+اللي موجودة عندهابالنسبة بال Java بالنسبة إلينا
+
+114
+00:08:11,900 --> 00:08:15,820
+بال Java فهي كل ال exceptions presented by classes
+
+115
+00:08:15,820 --> 00:08:19,300
+وبالتالي أنا بصير دكتور عالم ممل يعني هيك الإشعار
+
+116
+00:08:19,300 --> 00:08:23,580
+اللي بدي يجيني هو عبارة عن object object من class
+
+117
+00:08:23,580 --> 00:08:26,400
+الإشعار اللي بترد ليه ال Java virtual machine لل
+
+118
+00:08:26,400 --> 00:08:29,420
+application تبعي أو لل program تبعي عبارة عن
+
+119
+00:08:29,420 --> 00:08:34,660
+object طيب وكل ال exception هذه أو كل classes هي
+
+120
+00:08:34,660 --> 00:08:37,800
+عبارة عن sub classes أو derived من ال throwable
+
+121
+00:08:37,800 --> 00:08:45,860
+derived from throwableالـ Hierarchy تبعت الـ
+
+122
+00:08:45,860 --> 00:08:51,180
+exception هيها نقول
+
+123
+00:08:51,180 --> 00:08:54,460
+لك كلهم derived من مين؟ من الـ throwable في عندي
+
+124
+00:08:54,460 --> 00:08:58,180
+exception وفي عندي error لما أنا بتكلم على error
+
+125
+00:08:58,180 --> 00:09:05,820
+بتكلم على خطأ برنامج مالوش دخل فيهيعني هيك أن الـ
+
+126
+00:09:05,820 --> 00:09:09,060
+instructions تبعت صحيحة 100% الـ Java Virtual
+
+127
+00:09:09,060 --> 00:09:11,420
+Machine لما عملت Analysis لها و بعتتها لل
+
+128
+00:09:11,420 --> 00:09:15,980
+operating system الكلام كان صحيح 100% لكن ال
+
+129
+00:09:15,980 --> 00:09:21,560
+operating system افتقر أو ماقدرش يروح مثلا يرسم ال
+
+130
+00:09:21,560 --> 00:09:26,060
+button على الشاشة بشكل كويس أو ماقدرش يحدد أو يحط
+
+131
+00:09:26,060 --> 00:09:28,340
+ال button في المكان المحدد على الرغم انه available
+
+132
+00:09:28,340 --> 00:09:34,600
+فهذا الخطأبعيد عن برنامجك فهو مش من مسئوليتك انت
+
+133
+00:09:34,600 --> 00:09:39,500
+تعملي ليه handling وغالبا لما بتكلم على error لازم
+
+134
+00:09:39,500 --> 00:09:43,160
+البرنامج نعمله terminate خلاص إنه صار في عندي
+
+135
+00:09:43,160 --> 00:09:47,200
+error مش أنا مسئول عنه كبرنامج ممكن ال operating
+
+136
+00:09:47,200 --> 00:09:50,320
+system مش قادر يعمل allocation ل memory معينة
+
+137
+00:09:50,320 --> 00:09:53,800
+memory cell وبالتالي قرر يعمل termination ال
+
+138
+00:09:53,800 --> 00:09:57,300
+process أو ال thread اللي كنت أنا شغال عليها في
+
+139
+00:09:57,300 --> 00:09:59,820
+malware على ال system وراح يعمللها kill فهذه
+
+140
+00:09:59,820 --> 00:10:03,370
+الأخطاءمش من مسئوليتنا احنا كـ Programmer أو كـ
+
+141
+00:10:03,370 --> 00:10:08,870
+Developer طيب في المقابل في عند الـ exceptions
+
+142
+00:10:08,870 --> 00:10:14,650
+اللي هي بتكون ناتجة عن ال program activity عن نشاط
+
+143
+00:10:14,650 --> 00:10:20,810
+برنامجي مثلا علمونا في الرياضيات سالب واحد تحت
+
+144
+00:10:20,810 --> 00:10:26,090
+الجذر عملية غير معرفة مصبوط؟ كذلك لما بدأت أجسم
+
+145
+00:10:26,090 --> 00:10:31,250
+على صفر برضه عملية غير معرفةالان هدف الـ syntax
+
+146
+00:10:31,250 --> 00:10:35,650
+يعني لو انا جيت هيك و قلتله انا في عندي integer I
+
+147
+00:10:35,650 --> 00:10:43,450
+equal ناقص واحد و قلتله double X equal square root
+
+148
+00:10:43,450 --> 00:10:53,230
+لل I math dot square root لل I syntax صحيح مية في
+
+149
+00:10:53,230 --> 00:10:59,730
+المية لكن في ال runtime في error ناتج عن برنانجيهي
+
+150
+00:10:59,730 --> 00:11:01,570
+Error ناتجة عن برنامجي لأنه رصدنا في عندي
+
+151
+00:11:01,570 --> 00:11:05,830
+Undefined Value كذلك لو أنا جسمت على صفر في الحالة
+
+152
+00:11:05,830 --> 00:11:09,710
+هذه في الحالة هذه أنا لازم أنتبه أو برنامج يكون
+
+153
+00:11:09,710 --> 00:11:14,710
+جاهز يحل هيك مشكلة عشان برنامج يكون قوي لازم يكون
+
+154
+00:11:14,710 --> 00:11:18,390
+جاهز يحل هيك المشكلة والأمر بسيط جدا بما أن ال
+
+155
+00:11:18,390 --> 00:11:20,650
+system أو ال Java Virtual Machine هتبعت الإشعار
+
+156
+00:11:20,650 --> 00:11:25,110
+بالخطأ أنا بقدر أخد الخطأ هذا أجهز نفسي للخطأ هذا
+
+157
+00:11:25,110 --> 00:11:29,950
+وأتعامل معاه طيبيعني احنا الان بنتكلم على error و
+
+158
+00:11:29,950 --> 00:11:33,850
+exception ال error بعيد عن ال control طبعا احنا
+
+159
+00:11:33,850 --> 00:11:37,290
+مالاش ندخل فيه احنا بنتكلم على ال exception في ال
+
+160
+00:11:37,290 --> 00:11:41,850
+exception هان حسب ال hierarchy انا عندي نوعين في
+
+161
+00:11:41,850 --> 00:11:45,450
+عندي ال input output exception وهذا لما انا بأرتبط
+
+162
+00:11:45,450 --> 00:11:50,670
+في أي شغلة بعيدة عن البرنامج مثل قراءة ملفعفوا،
+
+163
+00:11:50,670 --> 00:11:55,270
+الكتابة على ملف، الاتصال بالإنترنت أو بالشبكة،
+
+164
+00:11:55,270 --> 00:11:59,450
+بتستخدم URL عشان مش عارف إيش، كل الشغلات هذه لها
+
+165
+00:11:59,450 --> 00:12:03,970
+علاقة بال input و output exception، بدي أطبع على
+
+166
+00:12:03,970 --> 00:12:08,150
+الطابع و مش جادر أو مش واصل للطابع أو ما شابه، إلى
+
+167
+00:12:08,150 --> 00:12:12,740
+آخرينالـ runtime exception أنه أنا أثناء تشغيل
+
+168
+00:12:12,740 --> 00:12:17,180
+البرنامج صار في عندي بعض الأخطاء اللي ممكن توقف
+
+169
+00:12:17,180 --> 00:12:23,520
+البرنامج مثل الـ casting إيش ال class casting؟
+
+170
+00:12:23,520 --> 00:12:28,420
+يعني أنا في عندي integer integer
+
+171
+00:12:28,420 --> 00:12:35,000
+X عندي integer X وعندي string شوية لأن اللي حالتها
+
+172
+00:12:35,000 --> 00:12:45,680
+شوية خاصة في عندي string تمام؟y equal hello بنفع
+
+173
+00:12:45,680 --> 00:12:54,240
+أروح أقوله x equal مش
+
+174
+00:12:54,240 --> 00:13:00,260
+هي cast؟ مصبوط، بنفع هذا الكلام؟ ليش؟ لأنه ال data
+
+175
+00:13:00,260 --> 00:13:03,660
+مختلفة تماماً طيب، هل أقلت بنفع أحط integer في
+
+176
+00:13:03,660 --> 00:13:08,020
+double أعمل casting؟ أه، بنفع، بنفع طيب لو العكس؟
+
+177
+00:13:08,850 --> 00:13:13,190
+الـ value والـ size تبع ال data يعني مانفعش أحطه
+
+178
+00:13:13,190 --> 00:13:18,210
+في integer لكن مانفع أحطه في long مانفعش أروح أخد
+
+179
+00:13:18,210 --> 00:13:22,610
+والله ال ال .. اللهم صلى الله عليه و سلم يا محمد
+
+180
+00:13:22,610 --> 00:13:28,640
+ال big sizeيعني مثلا نجي نقول والله عندى رقم اتنين
+
+181
+00:13:28,640 --> 00:13:30,960
+مليون وسبعة مية وخمسين ألف ومية ومش عارف كدهش
+
+182
+00:13:30,960 --> 00:13:34,480
+واروح بده أحطها في short طبما هي معروفة ال maximum
+
+183
+00:13:34,480 --> 00:13:37,680
+value تبعتها وبالتالي أنت عملك تعمل exceeding لل
+
+184
+00:13:37,680 --> 00:13:40,860
+value وبالتالي عملية ال cast تبعتناها مبتمش
+
+185
+00:13:40,860 --> 00:13:44,680
+وبالتالي لما أنا بتكلم على ال casting معناته لازم
+
+186
+00:13:44,680 --> 00:13:48,160
+يكون في عندي setup أو في عندي شكل أو بآخر اتنين
+
+187
+00:13:48,160 --> 00:13:51,740
+بيتقابلوا في مرحلة معينة عشان أقدر أعمل عليها
+
+188
+00:13:51,740 --> 00:13:53,580
+casting فضلي
+
+189
+00:14:00,760 --> 00:14:10,800
+لما ايش بتساوي تقوليله integer x equal 1.2 دي مش
+
+190
+00:14:10,800 --> 00:14:18,420
+هيك موقفين بمعرفة integer ومعرفة double طيب اه لإن
+
+191
+00:14:18,420 --> 00:14:25,610
+مجرد تقوليله هيك هاي double y equal واحد ونصX
+
+192
+00:14:25,610 --> 00:14:30,110
+equals Y هك انت بتقول ايه؟ هك الطبيعي Error Two
+
+193
+00:14:30,110 --> 00:14:33,510
+different data types بس لما أنا بدي أدخل موضوع ال
+
+194
+00:14:33,510 --> 00:14:36,930
+casting بيفرج وطبعا ال casting بعيد عن ال
+
+195
+00:14:36,930 --> 00:14:41,910
+primitive data أوضح الآن تعالي نتكلم تتذكر ال
+
+196
+00:14:41,910 --> 00:14:46,670
+employee كان في عند ال full-time employee وفي عند
+
+197
+00:14:46,670 --> 00:14:49,550
+ال part-time employee مظبوط؟
+
+198
+00:14:53,280 --> 00:14:57,780
+البيانات الرئيسية الـ ID والـ Name موجودة فوق هنا
+
+199
+00:14:57,780 --> 00:15:04,940
+الـ Hire Date والـ Grade وهنا
+
+200
+00:15:04,940 --> 00:15:11,740
+في عند الـ Working Hours ساعات العمل والـ
+
+201
+00:15:11,740 --> 00:15:16,940
+Hour Rate مظبوط؟
+
+202
+00:15:16,940 --> 00:15:24,530
+تخيل أنت الآن أنا عندي .. عنديobject من الـ part
+
+203
+00:15:24,530 --> 00:15:29,990
+-time و بدى أخزنه بالـ full-time بينفع؟ بينفعش
+
+204
+00:15:29,990 --> 00:15:37,470
+بينفعش بس بينفع أخزنه وين؟ في ال employee ليش؟ لأن
+
+205
+00:15:37,470 --> 00:15:41,990
+العلاقة بينهم is a subclass وبالتالي لازم يكون في
+
+206
+00:15:41,990 --> 00:15:45,890
+علاقة ما بين ال two objects لما أنا بدى أفكر
+
+207
+00:15:45,890 --> 00:15:51,070
+بعملية ال casting بغير هيك دائما حكون في عندك خطأ
+
+208
+00:15:51,070 --> 00:15:56,670
+في ال castingطيب، ننتقل للنقبة اللي بعديها الآن من
+
+209
+00:15:56,670 --> 00:15:59,530
+الـ exception في الـ runtime اللي في عندي null
+
+210
+00:15:59,530 --> 00:16:02,770
+pointer exception أنا قاعد بقرأ الـ data و بحللها
+
+211
+00:16:02,770 --> 00:16:09,110
+من الملف في لحظة لما قرأت رجعتلي null، فاضي أو
+
+212
+00:16:09,110 --> 00:16:11,810
+أجيت و أنا أثناء بقرا في ال array أنا معرف ال
+
+213
+00:16:11,810 --> 00:16:18,610
+array خمس عناصر integer خمسة وروحت وقلتله a of
+
+214
+00:16:18,610 --> 00:16:27,770
+خمسة equal سبعة، صح؟يعني انا اشي قلتله انتجار a
+
+215
+00:16:27,770 --> 00:16:35,230
+بيتساوى new انتجار خمسة ايش هدى؟ معناه ان هدى عندى
+
+216
+00:16:35,230 --> 00:16:38,830
+اعلى index اربعة وفي لحظة من اللحظات اللي جيت
+
+217
+00:16:38,830 --> 00:16:45,670
+قلتله f خمسة equal سبعة يعني
+
+218
+00:16:45,670 --> 00:16:50,400
+انا قاعد بدي عنوان او indexمش موجود أصلا فهذا
+
+219
+00:16:50,400 --> 00:16:54,300
+exception الآن ولا عمره البرنامج في ال compilation
+
+220
+00:16:54,300 --> 00:16:59,400
+حدك على هذا error ليش؟
+
+221
+00:16:59,400 --> 00:17:02,980
+لأنه هذا من ناحية syntax صحيح لكن في ال runtime
+
+222
+00:17:02,980 --> 00:17:05,680
+أنا فيه عندى مشكلة وبالتالي هذه الأخطاء اللى لازم
+
+223
+00:17:05,680 --> 00:17:11,360
+أنتبه للتعامل معاها ال
+
+224
+00:17:11,360 --> 00:17:14,500
+array index out of bounds لما بكون انا بحاول اعمل
+
+225
+00:17:14,500 --> 00:17:19,810
+access ل elementبعد جبل أو بعد ال array اللي
+
+226
+00:17:19,810 --> 00:17:23,630
+موجودة عندهم يعني بيبدأ ال index من صفر اروح أقوله
+
+227
+00:17:23,630 --> 00:17:28,470
+a of سالب واحد او اروح أقوله a خمسة او an اللي هو
+
+228
+00:17:28,470 --> 00:17:31,850
+اعلى انه ال index تبعتي ال casting لما يكون في
+
+229
+00:17:31,850 --> 00:17:35,590
+احاول بعمل casting ومافيش is a ك relation موجودة
+
+230
+00:17:35,590 --> 00:17:39,510
+بين ال two objects و null pointer exception لما
+
+231
+00:17:39,510 --> 00:17:43,150
+انا في الآخر ترجع ل null value بدل object انا مش
+
+232
+00:17:43,150 --> 00:17:45,870
+متوقع ان احللها طيب
+
+233
+00:17:54,200 --> 00:17:59,320
+ما هو عشان انت مش قادرة تعرفي ايش السبب او ايش ..
+
+234
+00:17:59,320 --> 00:18:02,580
+كيف تتعامل مع ال error اللي صار عندك و كان لان انا
+
+235
+00:18:02,580 --> 00:18:05,500
+لو انت بتقرأ من ملف على سبيل المثال و رجعلك null
+
+236
+00:18:05,500 --> 00:18:10,760
+المعناته اما في صدر فاضي في نص الملف في نص ال text
+
+237
+00:18:10,760 --> 00:18:15,120
+file اللي عندك و انا بدي اتحاول تشوف كيف ممكن
+
+238
+00:18:15,120 --> 00:18:20,650
+تستمريأو ممكن تكون في عندي والله ماعرفش ان القيمة
+
+239
+00:18:20,650 --> 00:18:22,970
+مش معملها initialization وانا أخدتها و بحاول ايش
+
+240
+00:18:22,970 --> 00:18:25,790
+بعمل لها parsing او بحاول اتعامل معاها فانت هان
+
+241
+00:18:25,790 --> 00:18:29,130
+ضروري تكون فاهم ال code تبعك حسب ايش البرنامج اللي
+
+242
+00:18:29,130 --> 00:18:32,570
+بتشتغل عليه طيب تعالى نجرب البرنامج البسيط هذا
+
+243
+00:18:32,570 --> 00:18:39,830
+اللي هيظهر فيه ال exception انا هان عامل class
+
+244
+00:18:40,890 --> 00:18:45,410
+Exception وعمل فيه main فاضي مش فيه حاجة بدأ اشتغل
+
+245
+00:18:45,410 --> 00:18:49,490
+فيه كتالي او بدأ اكتب فيه code و code بسيط جدا ال
+
+246
+00:18:49,490 --> 00:18:52,270
+code هذا عشان اشوف الخطأ او ال exception كيف بده
+
+247
+00:18:52,270 --> 00:18:58,710
+يظهر هاي
+
+248
+00:18:58,710 --> 00:19:07,590
+integer x equals 7 وهي كمان integer y equals 2 وهي
+
+249
+00:19:07,590 --> 00:19:09,510
+في عندى double
+
+250
+00:19:12,900 --> 00:19:21,340
+الـ result equal x على y و بدي أروح أقوله هان و
+
+251
+00:19:21,340 --> 00:19:30,100
+أطبع ليه اللي هي ال result من ناحية code لأن ال
+
+252
+00:19:30,100 --> 00:19:34,680
+code صحيح 100% ولا لا في أي مشكلة؟ لأ واحدة تقول
+
+253
+00:19:34,680 --> 00:19:38,320
+يا أستاذي أنت معرف double هان و بتجسم على integer
+
+254
+00:19:38,320 --> 00:19:41,700
+و هي أساسا انها integer و هيتخزن integer فنعمل run
+
+255
+00:19:45,340 --> 00:19:50,900
+Okay تلاتة منطق واحد يقول تلاتة و نص وراحت انتجار
+
+256
+00:19:50,900 --> 00:19:54,040
+مع انتجار فال result انتجار وبالتالي من البداية من
+
+257
+00:19:54,040 --> 00:20:00,000
+البداية انا ماعنديش مشكلة في الجسم تمام لو انا
+
+258
+00:20:00,000 --> 00:20:07,560
+اجيت و بدلت التنين هاد بصفر و انا شغلت البرنامج
+
+259
+00:20:07,560 --> 00:20:12,260
+هيظهر ال error اللي احنا بنتكلم عليه ظهر الخطأ
+
+260
+00:20:12,260 --> 00:20:17,920
+اللي احنا فعليافي الـ runtime لأن هذا الخطأ قبل ما
+
+261
+00:20:17,920 --> 00:20:23,240
+يظهر عندي على الشاشة تمام ال operating system رجع
+
+262
+00:20:23,240 --> 00:20:25,360
+إلى ال virtual machine ال virtual machine عمل
+
+263
+00:20:25,360 --> 00:20:31,000
+تثرون لل application هذه في خطأ مافيش handing عمل
+
+264
+00:20:31,000 --> 00:20:35,400
+terminate لل application وجملة الطباعة هذه ما تمتش
+
+265
+00:20:35,400 --> 00:20:44,280
+تمام احنا بدنا نطلع من هناOkay هذا هو البرنامج بكل
+
+266
+00:20:44,280 --> 00:20:49,120
+بساطة اللي انا كنتش اعمله اللي انا عشان اعمل
+
+267
+00:20:49,120 --> 00:20:54,240
+handling للخطاء اللي موجودة عندى بيلزمني مجموعة من
+
+268
+00:20:54,240 --> 00:21:00,380
+المفاهيم اول حاجة ال block احنا قبل شوية قلت لما
+
+269
+00:21:00,380 --> 00:21:05,460
+انا ال virtual machineتعمل الـ throne الـ
+
+270
+00:21:05,460 --> 00:21:09,320
+exception المفروض البرنامج التابع يكون قادر يمسك
+
+271
+00:21:09,320 --> 00:21:12,100
+الـ announcement الـ announcement هذا أو الـ
+
+272
+00:21:12,100 --> 00:21:15,240
+throne أو الـ exception هذا يعني قبل ما .. قبل ما
+
+273
+00:21:15,240 --> 00:21:17,660
+.. كمان مرة الـ virtual machine قبل ما بتوقف
+
+274
+00:21:17,660 --> 00:21:23,420
+البرنامج بتقوله هاي في خطأيعني بترد للبرنامج أهي
+
+275
+00:21:23,420 --> 00:21:27,360
+أن في خطأ بتتعامل معاه إذا بتعامل معاه بيعمل بكمل
+
+276
+00:21:27,360 --> 00:21:30,660
+execution غير هيك لأ عشان أتعامل مع الخطأ هذا
+
+277
+00:21:30,660 --> 00:21:36,400
+بيلزمني أتعامل أو في البداية أفهم أو أستخدم try ال
+
+278
+00:21:36,400 --> 00:21:39,860
+try هي عبارة عن ال block اللي المفروض تحتوي ال
+
+279
+00:21:39,860 --> 00:21:45,200
+code اللي ممكن يظهر من خلال الخطأ نرجع بشكل سريع
+
+280
+00:21:45,200 --> 00:21:50,160
+على البرنامج هذاهي البرنامج طبعا البرنامج بين هذا
+
+281
+00:21:50,160 --> 00:21:53,060
+و اللي أنا كتبته طبعا هذا كمان جربته سابقا انه
+
+282
+00:21:53,060 --> 00:21:58,200
+هنترك للمستخدم يدخل القيم تمام؟ هل في .. وين ممكن
+
+283
+00:21:58,200 --> 00:22:01,880
+انا احط او وين الخطأ اللي بدي أظهر عندي؟ ممكن انك
+
+284
+00:22:01,880 --> 00:22:06,320
+تدخل القيم و تدخل القيارات اه okay وبالتالي انا من
+
+285
+00:22:06,320 --> 00:22:10,220
+البداية ماعملتش validation على القيم المدخلة خصوصا
+
+286
+00:22:10,220 --> 00:22:14,910
+لما اتكلمت على denominator او ال divisorما دورتش
+
+287
+00:22:14,910 --> 00:22:19,670
+.. يعني ما فحصتش إن هو دخل صفر أو لأ عشان أقوله
+
+288
+00:22:19,670 --> 00:22:23,470
+بينفعش يدخلها مرة تانية طبعا هذه الطريقة صرت أنا
+
+289
+00:22:23,470 --> 00:22:27,350
+بأمنع ال error لا يظهر أساسا مش أنا بتعامل مع ال
+
+290
+00:22:27,350 --> 00:22:31,630
+error أنا بأمنعه لا يظهر من البداية لكن فعليا ال
+
+291
+00:22:31,630 --> 00:22:35,130
+statement الوحيد اللي بتطلع ال error هاي اللي هي
+
+292
+00:22:35,130 --> 00:22:40,610
+عملية القسمة يعني الخطأ فعليا لو أرجعنا هنا بشكل
+
+293
+00:22:40,610 --> 00:22:43,450
+سريع لل code اللي عندنا
+
+294
+00:22:47,230 --> 00:22:53,010
+في ال trace exception
+
+295
+00:22:53,010 --> 00:22:58,910
+ان ال thread من البرنامج الاساسي اللي حصل فيه عنده
+
+296
+00:22:58,910 --> 00:23:04,630
+خطأ هي نوعه arithmetic exception ال text تبعته
+
+297
+00:23:04,630 --> 00:23:10,670
+divided by zero divide قسم هاي when at exceptions
+
+298
+00:23:10,670 --> 00:23:15,430
+اسم ال class اللي عندي dot ال main method
+
+299
+00:23:16,670 --> 00:23:22,310
+exceptions.java الى اسم الملف كولون سطر رقم تسعة
+
+300
+00:23:22,310 --> 00:23:27,150
+وبالتالي بتديني تفاصيل واضحة عن ال error اللي صار
+
+301
+00:23:27,150 --> 00:23:32,050
+try
+
+302
+00:23:32,050 --> 00:23:36,010
+وبالتالي ال code اللي بده يحط في ال try اللي ممكن
+
+303
+00:23:36,010 --> 00:23:39,430
+يظهر الخطأ هو اللي حطه في ال try طبعا حط كل
+
+304
+00:23:39,430 --> 00:23:44,270
+برنامجي في ال try بينفع؟ أه بينفع بس بدك تفهم شغلة
+
+305
+00:23:44,270 --> 00:23:45,770
+في داخل ال try
+
+306
+00:23:49,070 --> 00:23:53,490
+لو افترضنا ان انا في عندى مجموعة من الأسطر وصار
+
+307
+00:23:53,490 --> 00:23:58,470
+الخطأ في السطر الرقم تلاتة بمجرد ال exception صار
+
+308
+00:23:58,470 --> 00:24:07,240
+هنا هيطلع براالـ try خلاص اللي جوا ال try هذا مش
+
+309
+00:24:07,240 --> 00:24:12,680
+هيتم تنفيظه عشان هيك مش صح تحط كل ال code في داخل
+
+310
+00:24:12,680 --> 00:24:17,280
+ال try مش صح تحط كل ال code في داخل ال try وإن
+
+311
+00:24:17,280 --> 00:24:22,880
+حطتي وإن حطتي دلالته واحدة فقط ان انت فعليا مش
+
+312
+00:24:22,880 --> 00:24:28,140
+قادر تعمل handling صح او مش فاهم برنامجك صح طيب
+
+313
+00:24:28,140 --> 00:24:34,030
+التانية catchوهو block بده ينخط تحت ل try مباشرة
+
+314
+00:24:34,030 --> 00:24:40,170
+يعني try catch
+
+315
+00:24:40,170 --> 00:24:46,810
+catch لإيش؟ احنا قبل شوية اتكلمنا على method بدها
+
+316
+00:24:46,810 --> 00:24:51,650
+تستلم تستلم ال announcement أو الإعلام لل java
+
+317
+00:24:51,650 --> 00:24:57,610
+virtual machine مين مسئولته؟ try استلمناها مين
+
+318
+00:24:57,610 --> 00:25:01,820
+اللي بده يفصف صلقان ويفهم إيش المحتويات؟الـ Catch
+
+319
+00:25:01,820 --> 00:25:06,980
+حسب الهيكلية السابقة لازم أنا أقوله لو كان هذا
+
+320
+00:25:06,980 --> 00:25:12,500
+الخطأ اللي صار arithmetic exception إيش بدي أخد
+
+321
+00:25:12,500 --> 00:25:18,280
+قرار؟ إيش بدي أعمل execution؟ لاحظي في ال code في
+
+322
+00:25:18,280 --> 00:25:22,180
+الأول كان
+
+323
+00:25:22,180 --> 00:25:25,600
+لما بظهر ال error بدون ال catch ال trial catch في
+
+324
+00:25:25,600 --> 00:25:31,140
+برنامج تبعيdrop خلاص بنعمله terminate طب لو أنا
+
+325
+00:25:31,140 --> 00:25:36,780
+عملت try و catch بقدر أكمل في بعض أو في بعض ال
+
+326
+00:25:36,780 --> 00:25:39,800
+code .. بعض ال code عفوا بعض ال code اللي موجود
+
+327
+00:25:39,800 --> 00:25:46,080
+عنده بعض ال catch طيب finally الآن ال finally هو
+
+328
+00:25:46,080 --> 00:25:51,050
+عبارة عن optional block بده ينحط بعدطبعا بالمناسبة
+
+329
+00:25:51,050 --> 00:25:55,070
+مافيش اي separator اي سطر of code بين ال try و بين
+
+330
+00:25:55,070 --> 00:25:58,790
+ال catch لأنه ممكن في داخل ال code تبعك تكتب اكتر
+
+331
+00:25:58,790 --> 00:26:02,810
+من try block فال catch تبعتها لازم تكون وراها
+
+332
+00:26:02,810 --> 00:26:07,450
+مباشرة طيب ال finally ال finally ال block as
+
+333
+00:26:07,450 --> 00:26:11,490
+optional بدي يكون بعد بعد ال catch في ال structure
+
+334
+00:26:11,490 --> 00:26:18,050
+ومهمته انه ينفذ اي codeتنفذ الـ code اللي موجود في
+
+335
+00:26:18,050 --> 00:26:22,510
+الـ finally سواء ظهر error ولا ماظهرش ان عمله
+
+336
+00:26:22,510 --> 00:26:25,670
+catch ولا ما عمللهوش بده يروح ينفذ اللي في الـ
+
+337
+00:26:25,670 --> 00:26:31,250
+finally ويطلع بعد هيك من البرنامج ال throw لما
+
+338
+00:26:31,250 --> 00:26:34,330
+احنا بنفكر نعمل generate لل application أو
+
+339
+00:26:34,330 --> 00:26:38,350
+generate عفوا لأي exception احنا بدناها يعني بده
+
+340
+00:26:38,350 --> 00:26:41,770
+اخل ال system هو اللي يعمل برنامجي هو اللي يعمل ال
+
+341
+00:26:41,770 --> 00:26:45,830
+throw لل exception مش ال java virtual machine طيب
+
+342
+00:26:47,870 --> 00:26:51,110
+وبالتالي لما انا بتكلم عن الـ exception handling
+
+343
+00:26:51,110 --> 00:26:57,590
+معناته انا بدي امسك الـ standard exceptions عشان
+
+344
+00:26:57,590 --> 00:27:02,630
+ارد على الأخطاء اللي بتصير أثناء برنامجي تمام؟
+
+345
+00:27:02,630 --> 00:27:06,490
+وامنع ان ال system ينعمله crash او ينعمله exit او
+
+346
+00:27:06,490 --> 00:27:07,350
+abnormal exit
+
+347
+00:27:11,090 --> 00:27:15,070
+وبالتالي اي exception من عمل الـ throne لازم امسكه
+
+348
+00:27:15,070 --> 00:27:19,490
+مين اللي بيعمل ال .. اللي بيعمل erase بشكل صحيح
+
+349
+00:27:19,490 --> 00:27:24,210
+لما انا شايف بقوله ايش قاعد بقوله لـ Java من خلال
+
+350
+00:27:24,210 --> 00:27:29,910
+الـ try انتبه هذا السطر هو اللي هيعمل الـ throne
+
+351
+00:27:29,910 --> 00:27:32,290
+هيعمل exception فأي message بتجهي منه
+
+352
+00:27:38,660 --> 00:27:43,760
+عشان تتفحص إيش ال action اللي بدك تاخديها طيب لو
+
+353
+00:27:43,760 --> 00:27:48,060
+أنا البرنامج تبعي عملت try و catch وظهر exception
+
+354
+00:27:48,060 --> 00:27:52,220
+أنا مش جادر أمسكه إيش بيصير؟ هو كأن ال try و catch
+
+355
+00:27:52,220 --> 00:27:56,300
+عالفاض مش موجودات وبالتالي بيعمل abnormal exit أو
+
+356
+00:27:56,300 --> 00:28:00,700
+terminate لل block اللي موجود عندها بس طبعا
+
+357
+00:28:00,700 --> 00:28:02,900
+البرنامج تبعي عمل try و catchإذا في try و catch و
+
+358
+00:28:02,900 --> 00:28:06,340
+finally قبل ما بعمل exit بروح بنفّذ وين اللي في
+
+359
+00:28:06,340 --> 00:28:10,560
+الـ finally بشكل عام ال try و ال catch بالشكل هذا
+
+360
+00:28:10,560 --> 00:28:15,400
+و ممكن أنا أستخدم أكتر من catch خلينا نروح نبدأ
+
+361
+00:28:15,400 --> 00:28:18,880
+نشتغل بعض ال code العملي مع ال try و ال catch على
+
+362
+00:28:18,880 --> 00:28:26,000
+المثال اللي احنا اشتغلنا عليها وين
+
+363
+00:28:26,000 --> 00:28:31,100
+الجملة اللي فيها error هي الجملة القسمة هي try
+
+364
+00:28:34,080 --> 00:28:39,180
+وبدأ أخلّي جملة الطباعة تبع القسمة هي موجودة معاها
+
+365
+00:28:39,180 --> 00:28:43,460
+أيضًا صار في عندي try مباشرة قاللي لـ try هد عليها
+
+366
+00:28:43,460 --> 00:28:46,780
+error بدها catch هاي catch نوع ال error اللي عندي
+
+367
+00:28:46,780 --> 00:28:51,960
+arithmetic exception
+
+368
+00:28:51,960 --> 00:28:59,360
+E ممكن أنا أروح أساوي أقول له ال object هذا لأنه
+
+369
+00:28:59,360 --> 00:29:05,200
+قبل شوية قولنا فيه ال stack مصبوطprint stack trace
+
+370
+00:29:05,200 --> 00:29:08,260
+وهذه الـ method بتطبع التفاصيل اللي احنا شايفينها
+
+371
+00:29:08,260 --> 00:29:12,300
+تحت في الخطأ السابق وعشان نتأكد بده راح اقوله هي
+
+372
+00:29:12,300 --> 00:29:19,860
+end أو كمان جملة اطباعة end
+
+373
+00:29:19,860 --> 00:29:27,340
+of ال arithmetic catch
+
+374
+00:29:27,340 --> 00:29:36,500
+وهي في انديهان endهذه كمان جملة out system out as
+
+375
+00:29:36,500 --> 00:29:42,480
+out وبدأ
+
+376
+00:29:42,480 --> 00:29:50,480
+أقول له هنا end of try وهذه هنا كمان بدأ أحط في
+
+377
+00:29:50,480 --> 00:29:56,020
+البداية عشان
+
+378
+00:29:56,020 --> 00:29:59,980
+نقدر نعمل tracing صح لل application تبعتنا ل start
+
+379
+00:29:59,980 --> 00:30:01,440
+of
+
+380
+00:30:04,100 --> 00:30:10,660
+الـ main اللي
+
+381
+00:30:10,660 --> 00:30:15,240
+عملناه بكل بساطة عملت print في بداية البرنامج أقول
+
+382
+00:30:15,240 --> 00:30:18,760
+له هذه البداية عرفت أخدت القيام جسمت طبعت ال
+
+383
+00:30:18,760 --> 00:30:24,580
+result هيها و قلت له في نهاية ال try في عندي جملة
+
+384
+00:30:24,580 --> 00:30:27,920
+print ال catch هيها
+
+385
+00:30:29,970 --> 00:30:32,910
+و حطيت فيها جملة print نهاية الـ catch و بدي أضع
+
+386
+00:30:32,910 --> 00:30:36,710
+نهاية ال application تبعي كمان أو نهاية ال main
+
+387
+00:30:36,710 --> 00:30:44,810
+method بسيطة وهي end of main خلصنا الآن بدي أجي
+
+388
+00:30:44,810 --> 00:30:51,950
+أعمل run بالقيم اللي موجودة، لاحظي الخطأ اللي ظهر
+
+389
+00:30:51,950 --> 00:30:58,400
+عندي هناليش؟ ليش ظهر بنفس النص السابق؟ لأن أنا كنت
+
+390
+00:30:58,400 --> 00:31:02,180
+عمالي بقوله print stack trace اللي هي بتحتوى على
+
+391
+00:31:02,180 --> 00:31:15,840
+المعلومات السابقة إذا أنا مابديش إياها هيك
+
+392
+00:31:15,840 --> 00:31:23,100
+بقوله cannot divide
+
+393
+00:31:27,200 --> 00:31:33,940
+by zero مثلا او اي code انت بدك تنفيه مافي مشكلة
+
+394
+00:31:33,940 --> 00:31:41,500
+وبالتالي هايه بداية نهاية او في داخل ال catch اخد
+
+395
+00:31:41,500 --> 00:31:46,100
+ال action وهي نهايتها وراح كمل بعد ال catch وراح
+
+396
+00:31:46,100 --> 00:31:50,420
+كمل بعد ال catch في الحالة الأولى بمجرد انه الخطأ
+
+397
+00:31:50,420 --> 00:31:53,840
+صار وما نعملهش catch ايش هصير في البرنامج هيروح
+
+398
+00:31:53,840 --> 00:32:01,800
+طيب الآنلو انا روحت بدل ال arithmetic قلتله ان
+
+399
+00:32:01,800 --> 00:32:09,500
+عندي input output exception كمان؟
+
+400
+00:32:09,500 --> 00:32:15,620
+معظم ال IDEs الآن ايش بتحطوا هتساوي؟ هتقول ان
+
+401
+00:32:15,620 --> 00:32:20,520
+الخطأ فعليا هنا بقعد بقوللي انت بتحاول تعمل input
+
+402
+00:32:20,520 --> 00:32:24,860
+output exception وانت فعليا في code تبعكمافيش ولا
+
+403
+00:32:24,860 --> 00:32:28,600
+حاجة علاقة بالـ input و الـ output خلّيني انا اروح
+
+404
+00:32:28,600 --> 00:32:34,820
+اشوف و اقوله null pointer exception مافيش مشكلة في
+
+405
+00:32:34,820 --> 00:32:41,240
+الموضوع الان لاحظي ان ال system هيعمل erase ل
+
+406
+00:32:41,240 --> 00:32:45,180
+error او ل exception اللي هو arithmetic exception
+
+407
+00:32:45,180 --> 00:32:48,980
+و انا عامل catch لمين؟يعني أنا فعلياً قاعد بحاول
+
+408
+00:32:48,980 --> 00:32:52,340
+أفسر أو بحاول أحل مشكلة Error مش هيطلع عندي
+
+409
+00:32:52,340 --> 00:32:56,620
+والـError اللي هيطلع مافيش ولا إله catch إيش بتوقع
+
+410
+00:32:56,620 --> 00:33:05,400
+البرنامج يساوي؟ Terminate، خلاص، هاي وانتهى الـHan
+
+411
+00:33:05,400 --> 00:33:11,460
+الآن هذه الخطأ اللي صار Han، نجله على الـCatch هل
+
+412
+00:33:11,460 --> 00:33:13,220
+هو null pointer exception؟ لأ هو arithmetic
+
+413
+00:33:13,220 --> 00:33:17,700
+exception، ماقدرش أسوي حاجةأعمل الـ Abnormal Exit
+
+414
+00:33:17,700 --> 00:33:22,960
+وخلصت طب مافيه catch ليش مكملش من بعدها لأ بيكمل
+
+415
+00:33:22,960 --> 00:33:25,580
+بعدها لو جدر يدخل لل block تبعت ال catch ويعمل
+
+416
+00:33:25,580 --> 00:33:28,160
+execution زي ما كان في الحالة الأولى في ال
+
+417
+00:33:28,160 --> 00:33:34,760
+arithmetic exception في الحالة الأولى الآن أنا
+
+418
+00:33:34,760 --> 00:33:37,680
+البرنامج ال execution انتقلت لل catch و بعد ال
+
+419
+00:33:37,680 --> 00:33:41,500
+catch كملت fluent بدون أي مشكلة طيب أنا ممكن
+
+420
+00:33:41,500 --> 00:33:42,660
+أستخدم أكتر من catch
+
+421
+00:33:46,400 --> 00:33:54,080
+الحالة هذه نعم لأ
+
+422
+00:33:54,080 --> 00:33:57,540
+لأ كان بيقول لي انت أساسا ما بتتعاملش في داخل ال
+
+423
+00:33:57,540 --> 00:34:01,020
+code داخل برنامجك مع أي input أو output ال process
+
+424
+00:34:01,020 --> 00:34:06,520
+وبالتالي انت بتحاول تعمل catching لأ exception مش
+
+425
+00:34:06,520 --> 00:34:11,480
+هيبين عندك بتسمي unquoted exception الحالة التانية
+
+426
+00:34:15,320 --> 00:34:25,800
+ماعملاش copy اللي
+
+427
+00:34:25,800 --> 00:34:30,180
+احنا سمناها ال null pointer ال null pointer
+
+428
+00:34:30,180 --> 00:34:35,940
+exception مافي مشكلة لأنه كونه لجل ال exception
+
+429
+00:34:35,940 --> 00:34:40,420
+سواء كانت في الأول أو في الآخر مش فارق كتير
+
+430
+00:34:44,330 --> 00:34:49,250
+null pointer exception arithmetic exception
+
+431
+00:34:49,250 --> 00:34:59,910
+وخلّينا بس ال code تبعتها دي عشان إيش نغيره null
+
+432
+00:34:59,910 --> 00:35:08,430
+pointer exception نفس
+
+433
+00:35:08,430 --> 00:35:13,520
+ال code ليش؟ راح فحص ال catchy الأولىمش هي في كمان
+
+434
+00:35:13,520 --> 00:35:18,140
+catch لجاها هي المطلوبة نفّذ فهذه الجزئية انتهينا
+
+435
+00:35:18,140 --> 00:35:24,420
+منها الآن حسب ال hierarchy السابقة في ال code اللي
+
+436
+00:35:24,420 --> 00:35:33,980
+موجود عندى كل exceptions
+
+437
+00:35:33,980 --> 00:35:38,970
+high جاء من مين؟من الـ super بالنسبة للـ runtime
+
+438
+00:35:38,970 --> 00:35:41,250
+ال exception هو عبارة عن super class و لا لا
+
+439
+00:35:41,250 --> 00:35:46,150
+جايبين من ال super لو أنا حققت ال super class عادي
+
+440
+00:35:46,150 --> 00:35:51,550
+بيعمل catch لأي runtime exception لأي runtime
+
+441
+00:35:51,550 --> 00:35:58,170
+exception يعني
+
+442
+00:35:58,170 --> 00:36:01,530
+لو أنا أجيت في لحظة من اللحظات وهذه بدي أعملها
+
+443
+00:36:01,530 --> 00:36:01,990
+comment
+
+444
+00:36:06,010 --> 00:36:11,910
+هي comment وهنا ده روح اقوله ايش exception
+
+445
+00:36:11,910 --> 00:36:17,470
+الان ال exception او كل ال subclasses derived من
+
+446
+00:36:17,470 --> 00:36:22,790
+ال exception فهيروح خلاص هايه الان اذا انت قررت
+
+447
+00:36:22,790 --> 00:36:25,850
+تستخدم واحد من ال super exception او عفوا من ال
+
+448
+00:36:25,850 --> 00:36:29,110
+super classes في ال exceptions انتبهي مايكونش في
+
+449
+00:36:29,110 --> 00:36:35,940
+البداية ليش؟ لأنه هيعمل matchمع كل ال subclasses
+
+450
+00:36:35,940 --> 00:36:43,980
+لأن العلاقة بينهم is a بين جثين أي أني sub is a
+
+451
+00:36:43,980 --> 00:36:50,020
+super مصبوخ ولا لأ؟ وبالتالي لما انا احطه هنا
+
+452
+00:36:50,020 --> 00:36:56,340
+معناته صار التحت unreachable catch مش حصلها ولا
+
+453
+00:36:56,340 --> 00:36:58,740
+بأي حال من الإحوال تعالى نشوف نشيل ال comments
+
+454
+00:36:58,740 --> 00:36:59,460
+اللي موجودة هنا
+
+455
+00:37:04,110 --> 00:37:09,030
+الداني خطأها للـ IDE راح يقول لي Unreachable Catch
+
+456
+00:37:09,030 --> 00:37:15,070
+Block مش هيصله بأي حال من الأحوال ليش؟ لأن فيه فوق
+
+457
+00:37:15,070 --> 00:37:18,770
+Super Exception حجب كل الوصول للي موجود عندها
+
+458
+00:37:18,770 --> 00:37:24,790
+تمام؟ وبالتالي الأصل إذا أنا بدي أشتغل هذه بيكون
+
+459
+00:37:24,790 --> 00:37:32,750
+في البداية يعني بدي أبدأ أرتب الـ Catch تبعتي للـ
+
+460
+00:37:32,750 --> 00:37:40,750
+SubException للـSubclass جابل الـSuperclass اللي
+
+461
+00:37:40,750 --> 00:37:47,730
+موجود عندها نعم تمام
+
+462
+00:37:47,730 --> 00:37:51,470
+هي
+
+463
+00:37:51,470 --> 00:37:57,570
+المعلومات اللي كنا نشوفها قبل شوية okay هانقصدك
+
+464
+00:37:57,570 --> 00:38:03,130
+okay معناته خلينا نوقف هذا هيكسأضع لك نفس التفاصيل
+
+465
+00:38:03,130 --> 00:38:06,330
+الموجودة سابقًا لأن ماهي التفاصيل؟ كانت عنوان الـ
+
+466
+00:38:06,330 --> 00:38:11,010
+exception عنوانه والـ callback method نظمه أو الـ
+
+467
+00:38:11,010 --> 00:38:14,910
+call method trace والـ line اللي كان فيها الخطأ
+
+468
+00:38:14,910 --> 00:38:25,250
+هذا هي نفس
+
+469
+00:38:25,250 --> 00:38:29,440
+البيانات المهمة اللي كانت تظهرعندك في الـ
+
+470
+00:38:29,440 --> 00:38:31,960
+arithmetic exception إذا بدك تشوفيه تاني هايو
+
+471
+00:38:31,960 --> 00:38:41,980
+المفروض okay بس منفعش ان انا اقولها كلها
+
+472
+00:38:41,980 --> 00:38:53,560
+Ctrl Z كمان واحدة وبعدين
+
+473
+00:38:53,560 --> 00:38:57,340
+هاي ال trace
+
+474
+00:39:02,970 --> 00:39:08,310
+نفس الخطأ بدون ولا فرق طيب عشان نروح باتجاه نخلص
+
+475
+00:39:08,310 --> 00:39:14,930
+من الـ finally الآن بالـ finally تعالى نشوف قلنا
+
+476
+00:39:14,930 --> 00:39:21,210
+ال final وين لازم تكون تكون آخر حاجة finally
+
+477
+00:39:21,210 --> 00:39:25,050
+system
+
+478
+00:39:25,050 --> 00:39:29,790
+out mandatory
+
+479
+00:39:29,790 --> 00:39:31,670
+execution
+
+480
+00:39:38,610 --> 00:39:41,130
+في كل الأحوال في كل الأحوال الانانس في عند
+
+481
+00:39:41,130 --> 00:39:47,190
+exception معامله quote صح هذا انا بدي احجبه بس لان
+
+482
+00:39:47,190 --> 00:39:56,350
+هو حمس كل ال exceptions ادي اعمل run-time لاحظي
+
+483
+00:39:56,350 --> 00:40:00,510
+تبع ال arithmetic اللي فوققال الـ Cannot divide by
+
+484
+00:40:00,510 --> 00:40:02,970
+zero ودينا تفاصيل على الـ exception end of
+
+485
+00:40:02,970 --> 00:40:06,210
+arithmetic خلصنا منه راح نتقل للـ finally
+
+486
+00:40:06,210 --> 00:40:09,450
+mandatory code execution أو mandatory execution
+
+487
+00:40:09,450 --> 00:40:14,670
+نفذوها وكمل برا البرنامج طيب تعالى نشوف الحالة هذه
+
+488
+00:40:14,670 --> 00:40:20,990
+لو أنا بدي أستبدل هذه بالـ null pointer exception
+
+489
+00:40:20,990 --> 00:40:27,710
+إيش اللي هيصير؟ اللي هيتنفذ جوا الـ finally طب و
+
+490
+00:40:27,710 --> 00:40:38,870
+اللي برا؟لأ مالوش قال
+
+491
+00:40:38,870 --> 00:40:42,330
+إنه صار في عندك exception هيو وبما إن الـ finally
+
+492
+00:40:42,330 --> 00:40:46,350
+هذه ال code لازم يتنفذ فرح نفذ ال code اللي في ال
+
+493
+00:40:46,350 --> 00:40:53,550
+finally وعمل إيه إيش exit لاحظ إن هو قال exception
+
+494
+00:40:53,550 --> 00:40:58,350
+in thread main صار في exceptionمصبوط وراح نفذ اللي
+
+495
+00:40:58,350 --> 00:41:03,770
+في الـ finally وطبعلي ال exception مش من خلال ال
+
+496
+00:41:03,770 --> 00:41:07,850
+catch من خلال ال Java virtual machine وبالتالي
+
+497
+00:41:07,850 --> 00:41:11,190
+برنامج عمل terminate لو ماعملش terminate كان راح
+
+498
+00:41:11,190 --> 00:41:15,350
+أوصل الجملة الأخيرة وكمل بمعنى آخر أن الـ finally
+
+499
+00:41:15,350 --> 00:41:20,810
+هذه لما تم وجد في كل الأحوال صار في error ولا
+
+500
+00:41:20,810 --> 00:41:24,130
+ماصارش طيب نشوف حالة ماصارش فيها error
+
+501
+00:41:30,950 --> 00:41:40,950
+يعني بدل ما اجسم على صفر اجسم على اتنين يعني
+
+502
+00:41:40,950 --> 00:41:44,810
+في كل الأحوال صار في error ماصارش ولا ماصارش في
+
+503
+00:41:44,810 --> 00:41:49,730
+حالة صار error ال catchإن اشتغلت ولا ما اشتغلتش
+
+504
+00:41:49,730 --> 00:41:54,250
+الـ finally must be executed و لازم تتنفذ وبهكسرت
+
+505
+00:41:54,250 --> 00:41:59,570
+أنا بقدر اتعامل مع ال error بشكل كويس جدا بس المهم
+
+506
+00:41:59,570 --> 00:42:03,410
+اكون فاهم ال structure اللي انا بدي اعمل فيها ال
+
+507
+00:42:03,410 --> 00:42:06,250
+handling تبع ال exception اللي موجودة عندي وهذه
+
+508
+00:42:06,250 --> 00:42:10,020
+الطريقة الأولى باعتمادنا على ال tryor catch إذا
+
+509
+00:42:10,020 --> 00:42:13,840
+كنت أنا برنامجي بناس تانية بتاخد منه instances أو
+
+510
+00:42:13,840 --> 00:42:17,000
+بتعمل عليه abstract class أو بتعمل extend أو
+
+511
+00:42:17,000 --> 00:42:22,520
+interface بقدر ألزمه بالـ try و ال catch عبر ال
+
+512
+00:42:22,520 --> 00:42:25,780
+term الأخير اللي هو ال throne وحنشوفه إن شاء الله
+
+513
+00:42:25,780 --> 00:42:29,400
+المحاضرة الجاية في أي سؤال يا بنات؟ الأمور تمام إن
+
+514
+00:42:29,400 --> 00:42:29,620
+شاء الله
+
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_postprocess.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..da5997e6825075e5727fe19e862ff0b19935365d
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_postprocess.srt
@@ -0,0 +1,2260 @@
+1
+00:00:20,750 --> 00:00:22,630
+بسم الله والحمد لله والصلاة والسلام علي رسول الله
+
+2
+00:00:22,630 --> 00:00:25,230
+اليوم ان شاء الله يا بنات هنتكلم على ال Java
+
+3
+00:00:25,230 --> 00:00:29,550
+collections موضوع مهم و من المواضيع اللي رفعت ال
+
+4
+00:00:29,550 --> 00:00:33,430
+Java لفوق و خصوصا لما نسينا ان نتكلم عن ال generic
+
+5
+00:00:33,430 --> 00:00:39,910
+program الآن ال Java collection بتكلم على واحدة من
+
+6
+00:00:39,910 --> 00:00:43,270
+ال data structures من تركيب البيانات و المفروض ان
+
+7
+00:00:43,270 --> 00:00:48,810
+انت اما خلصت data structure او تردسيها حالياإيش
+
+8
+00:00:48,810 --> 00:00:52,110
+فكرتها إن هذا ال object اللي هو ال collection بدي
+
+9
+00:00:52,110 --> 00:00:57,170
+شير لمين؟ reference ل object آخر وهذا الكلام
+
+10
+00:00:57,170 --> 00:01:02,250
+بيعطينا مفهوم مهم جدا إن ال contents تبع ال
+
+11
+00:01:02,250 --> 00:01:06,330
+collection عبارة عن reference data type not
+
+12
+00:01:06,330 --> 00:01:12,510
+primitive data type تمام؟ وبالتالي إيش نوع ال
+
+13
+00:01:12,510 --> 00:01:16,520
+object اللي أنا ممكن أشيرله؟أي object أبسطها الـ
+
+14
+00:01:16,520 --> 00:01:19,820
+string اللي بنعرفه لك ممكن يكون ال collection عنده
+
+15
+00:01:19,820 --> 00:01:22,180
+collection of employees collection of cars
+
+16
+00:01:22,180 --> 00:01:24,800
+collection of students حسب ال data type اللي
+
+17
+00:01:24,800 --> 00:01:32,260
+موجودة وبالتالي ال object هذا ممكن يكون من أي type
+
+18
+00:01:32,260 --> 00:01:41,080
+is a relationship يعني أنا فيه عندي employeeوفي
+
+19
+00:01:41,080 --> 00:01:43,680
+عندي part-time employee وفي عندي full-time
+
+20
+00:01:43,680 --> 00:01:47,240
+employee، مظبوط؟ إيش العلاقة بينهم؟ ال part-time
+
+21
+00:01:47,240 --> 00:01:51,280
+employee is a employee و ال full-time is an
+
+22
+00:01:51,280 --> 00:01:54,840
+employee يعني لو عملت collection .. collection من
+
+23
+00:01:54,840 --> 00:02:00,500
+ال employee بقدر يشير .. يشير لمين؟ يشير على full
+
+24
+00:02:00,500 --> 00:02:03,120
+-time و يقدر يشير على ال part-time لأن عبارة عن
+
+25
+00:02:03,120 --> 00:02:07,390
+العلاقة بينهم isdata structure إيش يعني generate
+
+26
+00:02:07,390 --> 00:02:10,710
+data structure؟ إنها مش مرتبطة بنوع معين من
+
+27
+00:02:10,710 --> 00:02:15,010
+البيانات مش مرتبطة بنوع معين من البيانات وبالتالي
+
+28
+00:02:15,010 --> 00:02:20,530
+بقدر ال list هذه تحتوي أي نوع من ال objects اللي
+
+29
+00:02:20,530 --> 00:02:24,490
+ممكن يخطر على بالك طيب السؤال اللي بيطرح نفسه لو
+
+30
+00:02:24,490 --> 00:02:28,410
+أنا بدي array أو بدي collection of integers شو بدي
+
+31
+00:02:28,410 --> 00:02:31,810
+أسوي؟
+
+32
+00:02:31,810 --> 00:02:36,320
+الآن أنا بدي على سبيل المثال بدي listوال data
+
+33
+00:02:36,320 --> 00:02:41,000
+تابعتها integer هذا
+
+34
+00:02:41,000 --> 00:02:46,140
+الكلام مستحيل يصير ليش؟ لأن هذا primitive data بس
+
+35
+00:02:46,140 --> 00:02:53,280
+مرت علينا في البداية ال rubber class اللي
+
+36
+00:02:53,280 --> 00:03:00,580
+هو integer وبالتالي ممكن انا اعمل collection of
+
+37
+00:03:00,580 --> 00:03:03,060
+integers لكن باعتمادي على ال rubber class تبع ال
+
+38
+00:03:03,060 --> 00:03:06,810
+integerمش على الـ Primitive Data اللي موجودة عندنا
+
+39
+00:03:06,810 --> 00:03:11,990
+تمام من
+
+40
+00:03:11,990 --> 00:03:14,730
+ال collections اللي موجودة عندى مجموعة ال
+
+41
+00:03:14,730 --> 00:03:20,670
+interfaces collection set list map و queue وانت
+
+42
+00:03:20,670 --> 00:03:23,130
+المفروض في ال data structure مرّت عليك شو يعني
+
+43
+00:03:23,130 --> 00:03:25,640
+queueواستخدمتيها بالـ Java وعملتي الـ
+
+44
+00:03:25,640 --> 00:03:28,560
+implementation بالـ Java و stack و link list إلى
+
+45
+00:03:28,560 --> 00:03:33,020
+آخرهم من العناصر الموجودة أنا هركز اليوم على أو في
+
+46
+00:03:33,020 --> 00:03:35,400
+محاضرة نهادة مع ال collections على التلات عناصر
+
+47
+00:03:35,400 --> 00:03:40,160
+الموجودة اللي هي ال set و ال list و ال map و هشوف
+
+48
+00:03:40,160 --> 00:03:43,280
+كيف ممكن أستفيد من ال route interface اللي موجود
+
+49
+00:03:43,280 --> 00:03:46,800
+عندي اللي هي ال collection و ال class او ال
+
+50
+00:03:46,800 --> 00:03:49,420
+general class اللي انبنى او ال super class اللي تم
+
+51
+00:03:49,420 --> 00:03:53,650
+بناءه على ال interface اللي موجود عندهاcollection
+
+52
+00:03:53,650 --> 00:03:58,490
+interface و collections class طبعا عادة انا مش هدق
+
+53
+00:03:58,490 --> 00:04:02,470
+معاكي على ال spelling كتير خصوصا عندما تكتب ..
+
+54
+00:04:02,470 --> 00:04:05,950
+خليك تكتب code بس بدك تنتبه من البداية ان انا في
+
+55
+00:04:05,950 --> 00:04:09,770
+عند collection بتمثل interface و في عند
+
+56
+00:04:09,770 --> 00:04:13,610
+collections بتمثل class وبالتالي ال calling لهذه
+
+57
+00:04:14,470 --> 00:04:17,470
+غير، يعني أنا الآن ممكن أstudy ال collections و
+
+58
+00:04:17,470 --> 00:04:20,110
+أstudy كل ال static method اللي في داخلها لكن
+
+59
+00:04:20,110 --> 00:04:23,130
+ماقدرش أستفيد من ال collection اللي جاريه من خلال
+
+60
+00:04:23,130 --> 00:04:28,410
+ال implementation طيب ال interface collection لأن
+
+61
+00:04:28,410 --> 00:04:31,910
+هو الأساس عامل implementation لمجموعة من ال method
+
+62
+00:04:31,910 --> 00:04:37,270
+اللي لها علاقة بعض بالاشبالإضافة والمسح والمقارنة
+
+63
+00:04:37,270 --> 00:04:40,750
+ما بين عناصر ال collection اللي موجودة يعني أنا
+
+64
+00:04:40,750 --> 00:04:47,590
+بتكلم على group of objects اول
+
+65
+00:04:47,590 --> 00:04:51,090
+حاجة ال collection can be converted to array
+
+66
+00:04:51,090 --> 00:04:59,510
+والعكس صحيح مرت عليك شغل اسمها arrays class dot في
+
+67
+00:04:59,510 --> 00:05:03,260
+عندنا شغل اسمها as listأو method اسمها as list
+
+68
+00:05:03,260 --> 00:05:08,500
+بتاخد مني array و بترجعلي الاش؟ بترجعلي list
+
+69
+00:05:08,500 --> 00:05:13,420
+بترجعلي list هنشوفها خلال ال code اللي موجود لكن
+
+70
+00:05:13,420 --> 00:05:17,160
+أهميتها أنه فعليا أنا بقدر أحول ال collection ل
+
+71
+00:05:17,160 --> 00:05:21,460
+array و العكس صحيح و بحور ال array ل collection
+
+72
+00:05:21,460 --> 00:05:21,960
+كذلك
+
+73
+00:05:27,930 --> 00:05:32,670
+الـ Interface Collection بيزودني بـ Iterator
+
+74
+00:05:32,670 --> 00:05:36,550
+بيزودني بـ Iterator إيش الـ Iterator؟ قولنا هو
+
+75
+00:05:36,550 --> 00:05:41,750
+عبارة عن application أو counter بيمكنني أني أمر
+
+76
+00:05:41,750 --> 00:05:45,330
+على عناصر الـ list أو ال collection اللي موجود
+
+77
+00:05:45,330 --> 00:05:50,390
+وشوفنا وين؟ مع ال scanner لمش قولنا كنا قوله while
+
+78
+00:05:50,390 --> 00:06:00,150
+ال scanner object dot hasnext أو has next line
+
+79
+00:06:00,150 --> 00:06:04,850
+الآن
+
+80
+00:06:04,850 --> 00:06:09,910
+هذا بنسميه iterator ايش ال iterator؟ هو عبارة عن
+
+81
+00:06:09,910 --> 00:06:14,290
+object بمور على كل عناصر ال collection على كل
+
+82
+00:06:14,290 --> 00:06:19,270
+عناصر ال collection ودر بالك هذه من أهم الميزات
+
+83
+00:06:19,270 --> 00:06:23,430
+اللي بتفرج بين ال scanner و ال buffered reader
+
+84
+00:06:25,610 --> 00:06:29,010
+وبالتالي وجود الـ iterator عشان انا أستفيد منه
+
+85
+00:06:29,010 --> 00:06:35,010
+ماهو الـ iterator؟ هو عبارة عن object بيخلّي
+
+86
+00:06:35,010 --> 00:06:38,770
+البرنامج يمر عبر عناصر الـ collection كلها element
+
+87
+00:06:38,770 --> 00:06:45,910
+إلى element وبقدر من خلاله أعمل remove لل element
+
+88
+00:06:45,910 --> 00:06:49,990
+يعني انت تخيلي ان في عندي list عليها مجموعة من
+
+89
+00:06:49,990 --> 00:06:54,270
+الألوان R أو Red أو Green
+
+90
+00:06:57,980 --> 00:07:02,060
+Blue هاي ال RGB وهاي في عندي مثلا ال white في
+
+91
+00:07:02,060 --> 00:07:05,680
+الآخر ال
+
+92
+00:07:05,680 --> 00:07:12,520
+iterator object عادة يشير لأول element في ال list
+
+93
+00:07:12,520 --> 00:07:16,560
+اللي موجودة عندي هنا في method الأصل تقول ليه في
+
+94
+00:07:16,560 --> 00:07:19,780
+data ولا مفيش يعني ال iterator الأصل يكون فيه dot
+
+95
+00:07:19,780 --> 00:07:23,360
+has next زي ما شوفنا مع ال scanner هذه Boolean
+
+96
+00:07:23,360 --> 00:07:28,820
+functionالان لما انا بقوله الـ iterator.next
+
+97
+00:07:28,820 --> 00:07:34,820
+مباشرة بيرجعلي ب object من نفس ال data type اللي
+
+98
+00:07:34,820 --> 00:07:39,200
+انبنت علي يمين ال collection hand string هيرجع
+
+99
+00:07:39,200 --> 00:07:44,280
+bred و مباشرة ال iterator هيتحرك للأمام خطوة عشان
+
+100
+00:07:44,280 --> 00:07:48,320
+هيك بنقول احنا ال walks through the collections
+
+101
+00:07:48,320 --> 00:07:51,920
+element بمشي من خلال ال element بظل يمشي لما متى
+
+102
+00:07:51,920 --> 00:07:56,910
+يصلالنغل اللي في الآخر مافيش element معناته هتكون
+
+103
+00:07:56,910 --> 00:08:02,930
+ال method has next ال iterator dot has next بترجع
+
+104
+00:08:02,930 --> 00:08:07,610
+ب false طيب ال current position اللي أنا بقشر عليه
+
+105
+00:08:07,610 --> 00:08:11,430
+بإمكاني زي ما بقرأه بال next ممكن أروح أقوله ال
+
+106
+00:08:11,430 --> 00:08:18,370
+iterator dotremove عشان يحذف ال element هذا من ال
+
+107
+00:08:18,370 --> 00:08:21,590
+collection عشان هيك بقول انه بقدر يمر على عناصر ال
+
+108
+00:08:21,590 --> 00:08:24,990
+collection and remove elements from the collection
+
+109
+00:08:24,990 --> 00:08:32,270
+during the iteration طيب تماممعناته أنا الآن صرت
+
+110
+00:08:32,270 --> 00:08:35,610
+بتكلم على ال data وصار بإمكاني أحصل على iterator
+
+111
+00:08:35,610 --> 00:08:39,770
+أمر عليها وبالطريقة التقليدية اللي إحنا بنعرفها في
+
+112
+00:08:39,770 --> 00:08:43,090
+عند list عدد العناصر اللي فيها خمسة بقدر أعمل for
+
+113
+00:08:43,090 --> 00:08:46,990
+loop و أمر عليهم، أه تقدر غالبا تشتغل من خلال ال
+
+114
+00:08:46,990 --> 00:08:54,670
+index اللي موجود ال collections class بزودني
+
+115
+00:08:54,670 --> 00:08:58,790
+بمجموعة من ال aesthetic methods إيش يعني aesthetic
+
+116
+00:08:58,790 --> 00:08:59,410
+methods؟
+
+117
+00:09:02,920 --> 00:09:06,460
+بقدر أستدعيها بدون مانشي object من ال class اللي
+
+118
+00:09:06,460 --> 00:09:12,560
+موجود عندي هذا يعني بصير أقوله أنا collections هذا
+
+119
+00:09:12,560 --> 00:09:20,320
+اسم ال class dot sort collection dot search حسب
+
+120
+00:09:20,320 --> 00:09:23,260
+إيش ال method اللي موجودة طبعا ما تاخديش اسم ال
+
+121
+00:09:23,260 --> 00:09:26,840
+search و ال sort بال spelling صحيح 100% قدر ما أن
+
+122
+00:09:26,840 --> 00:09:29,780
+عمالي بعبر على إيش ال methods اللي موجودة هذه من
+
+123
+00:09:29,780 --> 00:09:30,980
+أجل البحث وترتيب
+
+124
+00:09:33,730 --> 00:09:37,470
+والشغل اللي ممكن يلزمني على الـ collections start
+
+125
+00:09:37,470 --> 00:09:41,670
+ال sort هي موجودة لكن ال search بالمسمى نفسه شوية
+
+126
+00:09:41,670 --> 00:09:48,350
+هنشوفه تمام ال collections as a framework جمعت
+
+127
+00:09:48,350 --> 00:09:52,750
+مجموعة من ال element مع بعضهم واحنا فعليا هنشوفهم
+
+128
+00:09:52,750 --> 00:09:56,690
+في عند ال collection interface اللي حكينا عنه هيه
+
+129
+00:09:56,690 --> 00:10:04,570
+بنبني عليه interface آخر listو Interface Q ده مش
+
+130
+00:10:04,570 --> 00:10:09,350
+هنطرقله و Interface اسمه set و من ال interface
+
+131
+00:10:09,350 --> 00:10:14,010
+list في عندي array list وفي عندي stack المفروض
+
+132
+00:10:14,010 --> 00:10:17,210
+شوفتيها في ال data structure في عندك list شوفتيها
+
+133
+00:10:17,210 --> 00:10:20,430
+في ال data structure و priority queue شوفتيها في
+
+134
+00:10:20,430 --> 00:10:22,850
+ال data structure وبالتالي أنا مع ال list
+
+135
+00:10:22,850 --> 00:10:26,790
+interface فقط هعتمد على two classes اللي هي ال
+
+136
+00:10:26,790 --> 00:10:29,850
+array list فقط
+
+137
+00:10:30,890 --> 00:10:33,750
+الان في الـ hash أو في ال set في ال interface set
+
+138
+00:10:33,750 --> 00:10:38,190
+في عندي hash set و في عندي tree set طيب، هل في فرق
+
+139
+00:10:38,190 --> 00:10:42,610
+بين ال set و ال list؟ الأصل يكون فيه فرق مرت عليك
+
+140
+00:10:42,610 --> 00:10:46,470
+في ال data structure set؟ عفوا، في ال discrete
+
+141
+00:10:46,470 --> 00:10:50,790
+mathematics، اللي قضيت مفاصلة المجموعات ال sets
+
+142
+00:10:50,790 --> 00:10:58,940
+أهم تعريف فيها إيش كان؟ unordered groupof unique
+
+143
+00:10:58,940 --> 00:11:04,160
+elements عنصر واحد تمنع التكرار تمام؟ وبالتالي
+
+144
+00:11:04,160 --> 00:11:07,460
+فيها different implementation سواء باعتمادنا على
+
+145
+00:11:07,460 --> 00:11:11,480
+ال hash set أو ال tree set سنشوفهم بالاضافة لدي
+
+146
+00:11:11,480 --> 00:11:14,940
+واحد من ال collections اسمه map وانا بتكلم على
+
+147
+00:11:14,940 --> 00:11:22,140
+ordered pairs او ازواج بتكلم على keyو value بتكلم
+
+148
+00:11:22,140 --> 00:11:26,740
+على key و value هنتكلم في حينها على ال maps يعني
+
+149
+00:11:26,740 --> 00:11:30,600
+أنا فعليا هتكلم على three objects من ال
+
+150
+00:11:30,600 --> 00:11:33,840
+collections هتكلم على ال list أو ال array list
+
+151
+00:11:33,840 --> 00:11:41,540
+هتكلم على ال set و هتكلم على ال map هتكلم على ال
+
+152
+00:11:41,540 --> 00:11:48,820
+map الآن
+
+153
+00:11:48,820 --> 00:11:53,430
+لما أنا بتكلم أو نبدأ بال listال list هي عبارة عن
+
+154
+00:11:53,430 --> 00:12:00,350
+ordered collection ordered collection وبديش تفهمي
+
+155
+00:12:00,350 --> 00:12:06,390
+أو بديك تميزي بين sorted و ordered ايش يعني
+
+156
+00:12:06,390 --> 00:12:11,230
+sorted؟ مرتبة ordered مرتبة
+
+157
+00:12:12,230 --> 00:12:16,270
+أيوة، بس الآن أنا ببتكلم ordered يعني قاعد ببتكلم
+
+158
+00:12:16,270 --> 00:12:20,890
+على الترتيب، ترتيب العراصر حسب أو .. أو ليه وليت
+
+159
+00:12:20,890 --> 00:12:24,710
+قدومها أو حسب قدومها أو وجودها في ال list باشي
+
+160
+00:12:24,710 --> 00:12:28,450
+بقول العنصر الأول في ال list، الآن كمان مرة، نرجع
+
+161
+00:12:28,450 --> 00:12:37,390
+للألوان R أو Red، Green، Blue، اللي هي ال RGB
+
+162
+00:12:37,390 --> 00:12:42,820
+colorsالان لو انا هدول العناصر موجودين في list
+
+163
+00:12:42,820 --> 00:12:49,020
+بقول عنهم ordered العنصر الأول مين؟ Red، التاني
+
+164
+00:12:49,020 --> 00:12:53,460
+Green، التالت بلو و هكذا الأول، التاني، التالت،
+
+165
+00:12:53,460 --> 00:12:57,900
+هذه المفهوم في ordering عشان نعمل ترتيب أو ندّر
+
+166
+00:12:57,900 --> 00:13:02,940
+label لكن لما باجي بتكلم على sorted بدي ارتبهم
+
+167
+00:13:02,940 --> 00:13:07,240
+تبعا ل criteria معينةبدي أرتبهم على كريتيريا معينة
+
+168
+00:13:07,240 --> 00:13:11,300
+حسب .. هنا ممكن أقول الـ alphabetical character
+
+169
+00:13:11,300 --> 00:13:14,600
+بتيجي blue في الأول بعدين green بعدين red لأنه
+
+170
+00:13:14,600 --> 00:13:18,920
+بناء على الحرف لكن ممكن برضه أتكلم أنا بناء على ال
+
+171
+00:13:18,920 --> 00:13:22,600
+size ال string size أعملهم ordering تبع ال size
+
+172
+00:13:22,600 --> 00:13:27,320
+تيجي red تيجي blue بعدين تيجي وراها green في ال
+
+173
+00:13:27,320 --> 00:13:32,210
+sorted لازم يكون في sorting criteriaفي الـ ordered
+
+174
+00:13:32,210 --> 00:13:36,090
+كل element بيجي بياخد ال position وبياخد الترتيب
+
+175
+00:13:36,090 --> 00:13:46,110
+اللي هو إجا فيه بالإضافة
+
+176
+00:13:46,110 --> 00:13:50,410
+لـ inherited from ال collection ال list هتزود
+
+177
+00:13:50,410 --> 00:13:55,710
+مجموعة من العناصر اللي ممكن تعمل manipulate لل
+
+178
+00:13:55,710 --> 00:14:02,750
+elements من خلال ال indexأنا عندي list فيها خمس
+
+179
+00:14:02,750 --> 00:14:06,090
+عناصر بقدر أتعامل مع ال list من خلال ال index أه
+
+180
+00:14:06,090 --> 00:14:10,450
+بقدر لأن هي ordered لأن هي ordered يعني في عندي
+
+181
+00:14:10,450 --> 00:14:14,190
+position واحد اتنين تلاتة يعني في عندي index و
+
+182
+00:14:14,190 --> 00:14:19,030
+بقدر أستفيد منه search for element يعني بقدر أدور
+
+183
+00:14:19,030 --> 00:14:23,290
+لأن طالما في عندي index بقدر أعمل loopو بقدر امر
+
+184
+00:14:23,290 --> 00:14:27,450
+على العناصر اللي موجودة عندها بالاضافة بقدر احصل
+
+185
+00:14:27,450 --> 00:14:31,770
+على list iterator عشان امر على عناصر ال list اللي
+
+186
+00:14:31,770 --> 00:14:36,070
+موجودة عندها ال interface اللي اسمه list انه عمله
+
+187
+00:14:36,070 --> 00:14:40,670
+implementation من different classes الray list
+
+188
+00:14:40,670 --> 00:14:47,330
+link list و ال vector كلهم list كلهم عبارة عن list
+
+189
+00:14:48,600 --> 00:14:55,420
+الـ link list الأصل إنه كل object بيحتوي على ال
+
+190
+00:14:55,420 --> 00:14:59,940
+data اللي هي ال value ومؤشر أو pointer to next
+
+191
+00:14:59,940 --> 00:15:04,620
+object، مصبوط؟ يعني هيك بجنه نسميه كل object هو
+
+192
+00:15:04,620 --> 00:15:11,340
+عبارة عن node ال node بتحتوي على مشاقين data و
+
+193
+00:15:11,340 --> 00:15:18,600
+next node، مصبوط؟ و next node pointer، تمامالان
+
+194
+00:15:18,600 --> 00:15:23,260
+بقى عندى ال array list و ال vector ال array list و
+
+195
+00:15:23,260 --> 00:15:26,680
+ال vector هذه بتحتوي data و هذه بتحتوي data هذه
+
+196
+00:15:26,680 --> 00:15:31,500
+بتحتوي على pointers انا مابديش اياهم الان طيب الان
+
+197
+00:15:31,500 --> 00:15:36,360
+عشان اسأل او ايش الفرق اللى بين ال vector و ال
+
+198
+00:15:36,360 --> 00:15:44,920
+array list الفرق بكل بساطة ان ال data او ال vector
+
+199
+00:15:48,750 --> 00:15:54,530
+عادةً Synchronized ايش Synchronized؟ متزامن ومفهوم
+
+200
+00:15:54,530 --> 00:15:59,170
+التزامن في ال threading لحظة احنا روحنا علوان على
+
+201
+00:15:59,170 --> 00:16:06,490
+شغل اسمها multi threads او multi threading انه انا
+
+202
+00:16:06,490 --> 00:16:11,290
+اخلي ال application تبعي بدل ما كان بيشتغل ب one
+
+203
+00:16:11,290 --> 00:16:16,270
+flow في مرحلة من المراحل اروح اعمله اعمله split
+
+204
+00:16:19,760 --> 00:16:23,540
+يشتغل و بعد ذلك ممكن انا اجمع ال data في point
+
+205
+00:16:23,540 --> 00:16:27,800
+واحدة او اكمل هذه مرحلة ال split بنسميها ايش او كل
+
+206
+00:16:27,800 --> 00:16:34,320
+split بنسميها thread الفكرة فيها ان احصل على اداء
+
+207
+00:16:34,320 --> 00:16:38,420
+افضل لل application تبعي عبر اعطاء او خلال ال
+
+208
+00:16:38,420 --> 00:16:42,080
+application تبعي يدّي مهام اكتر لل CPU لان ال CPU
+
+209
+00:16:42,080 --> 00:16:46,520
+لان لما اتكلم البرنامج او اللي عندي core i7 و
+
+210
+00:16:46,520 --> 00:16:50,400
+جاعدين بتكلموا على تمانية coreأنا بالوضع التقييدي
+
+211
+00:16:50,400 --> 00:16:53,220
+في البرنامج تابع بشغل على one core هل في ممكن
+
+212
+00:16:53,220 --> 00:16:58,410
+أستفيد من ال course التانية؟ طيبهذه المفروضة الـ
+
+213
+00:16:58,410 --> 00:17:02,070
+Parallel الآن إذا أنا بدي أستفيد منها معناته بدي
+
+214
+00:17:02,070 --> 00:17:05,770
+يكون برنامجي عنده القدرة إنه ينفذ مجموعة من ال
+
+215
+00:17:05,770 --> 00:17:10,110
+task بشكل إيش متزامن عشان يقدر يستفيد من المعالج
+
+216
+00:17:10,110 --> 00:17:14,030
+بشكل كامل يستفيد من ال cores بشكل مكتمل الشغل
+
+217
+00:17:14,030 --> 00:17:17,530
+التاني حتى لو كان عندي one core عادة ال operating
+
+218
+00:17:17,530 --> 00:17:21,050
+system مش بروح بساوي بروح بيعمل scheduling لوقت
+
+219
+00:17:21,050 --> 00:17:24,950
+المعالج والمعالج سريع جدا، بصبت؟ وغالبا بكون
+
+220
+00:17:24,950 --> 00:17:30,830
+ideal، مابشتغلشأيش الحل؟ أن أخلّي برنامجي ينفذ
+
+221
+00:17:30,830 --> 00:17:34,330
+أكتر من task في نفس الواجهة فبصير بدل ما ال
+
+222
+00:17:34,330 --> 00:17:38,130
+operating system بدي ال application تبعي one slice
+
+223
+00:17:38,130 --> 00:17:41,630
+of thyme بروح بديتين، تين و تلاتة أو أربعة بس كل
+
+224
+00:17:41,630 --> 00:17:46,430
+واحدة اللحظة بتاخد different task هذا بنسمي multi
+
+225
+00:17:46,430 --> 00:17:50,450
+-threading الآن في الموضوع الـSynchronized لو كان
+
+226
+00:17:50,450 --> 00:17:53,950
+عندي thread أو two threads بدهم يصلوا لنفس ال
+
+227
+00:17:53,950 --> 00:17:58,490
+object of dataماذا سيحدث فيه؟ إذا قلت له
+
+228
+00:17:58,490 --> 00:18:04,530
+Synchronized فهو سيبحث عن الـ data هذه لحد ما ال
+
+229
+00:18:04,530 --> 00:18:07,970
+thread اللي مسكها في الأول يعمل release وهذا لما
+
+230
+00:18:07,970 --> 00:18:10,970
+تكون ال data critical والـ update عليها مهم لكل
+
+231
+00:18:10,970 --> 00:18:14,210
+يشوفه تخيّلي .. تخيّلي .. أنا في عندي two
+
+232
+00:18:14,210 --> 00:18:20,430
+different thread T1 و T2 هدولة بمثله teller في بنك
+
+233
+00:18:20,430 --> 00:18:26,410
+تمام؟ بمثله teller في بنك و بدهم يعملوا axisعلى
+
+234
+00:18:26,410 --> 00:18:33,450
+نفس الـ record في نفس الوقت الـ account و بدهم
+
+235
+00:18:33,450 --> 00:18:39,550
+يروحوا يعملوا with a draw بدهم يعملوا سحب هنا صاحب
+
+236
+00:18:39,550 --> 00:18:42,990
+الرصيد موجود في البنك اللي في الفرع المدينة اللي
+
+237
+00:18:42,990 --> 00:18:50,450
+موجود و عميل إله أو زبون آخر مع شيك بده يسحب و
+
+238
+00:18:50,450 --> 00:18:55,590
+ربنا قدر إن الاتنين دخلوا في نفس الوقتلأنه ممكن
+
+239
+00:18:55,590 --> 00:19:02,370
+يبقى في مشكلة لو كان الرصيد غير كافي ولا لأ تخيل
+
+240
+00:19:02,370 --> 00:19:07,730
+أن الرصيد فقط بيحتوي على ألف دولار وقيمة الشك هذا
+
+241
+00:19:07,730 --> 00:19:13,350
+معاها شك بـ 700 دولار وهذا بده يسحب 400 دولار
+
+242
+00:19:13,350 --> 00:19:19,970
+الأصل لو مافيش look أو مافيش synchronizationعلى
+
+243
+00:19:19,970 --> 00:19:22,930
+الـ record هذا، ماذا سيحدث؟ الـ tiller hand شاف
+
+244
+00:19:22,930 --> 00:19:26,870
+الرصيد ألف و ال tiller hand اللي شاف الرصيد ألف،
+
+245
+00:19:26,870 --> 00:19:31,730
+معناته العملية okay proved فسحب لهذا سبعمية و سحب
+
+246
+00:19:31,730 --> 00:19:36,970
+لهذا أربعمية فبيصير رصيد ال hand minus سالب مية،
+
+247
+00:19:36,970 --> 00:19:41,610
+بصبوط ولا لأ؟ بس هذا الكلام not allowed فإيش الحل؟
+
+248
+00:19:41,610 --> 00:19:45,190
+حتما في واحد من اتنين وصل لل resource قبل، صح؟
+
+249
+00:19:45,970 --> 00:19:48,950
+مفهوم الـ Synchronized أنه بمجرد تمسك ال data
+
+250
+00:19:48,950 --> 00:19:54,110
+source تعمل عليه lock يعني تمنع أي حد تاني يصلّه
+
+251
+00:19:54,110 --> 00:19:57,530
+لحد ما انا اعمله release وبالتالي الفرق .. احنا
+
+252
+00:19:57,530 --> 00:19:59,990
+بنعرف نشتغل ال system بنشتغل بال nano second
+
+253
+00:19:59,990 --> 00:20:04,370
+وبالتالي الفرق الزمني هيكون موجود بين ال tasks و
+
+254
+00:20:04,370 --> 00:20:07,930
+بقدر اعمل lock by default ال vector هو عبارة عن
+
+255
+00:20:07,930 --> 00:20:11,590
+Synchronized by default لكنه
+
+256
+00:20:13,060 --> 00:20:16,500
+الـ Unrealist، الـ Unrealist لأ طبعا لما أنا بتكلم
+
+257
+00:20:16,500 --> 00:20:19,920
+على الـ Synchronized و بدّي أعمل ال thread weight
+
+258
+00:20:19,920 --> 00:20:22,940
+معناته أنا فيه عندي ال time ال system تبعي مش
+
+259
+00:20:22,940 --> 00:20:26,380
+هيقدر يشتغل بالقدرة اللي كان بعته كاملة عشان هيك
+
+260
+00:20:26,380 --> 00:20:31,280
+بنقول في الـ Unsynchronized ال performance أفضل في
+
+261
+00:20:31,280 --> 00:20:35,660
+ال Unsynchronized بنقول ال performance أفضل لكنه
+
+262
+00:20:35,660 --> 00:20:38,880
+في ال Synchronized data أو ال Synchronized object
+
+263
+00:20:39,920 --> 00:20:42,980
+بكون متكلم على safer more safer ان ال data محمية
+
+264
+00:20:42,980 --> 00:20:45,920
+اكثر وبالتالي انا مافيش عندى مشكلة في ال system
+
+265
+00:20:45,920 --> 00:20:48,780
+هنتكلم عليها بالتفصيل ان شاء الله لما نتقل للموضوع
+
+266
+00:20:48,780 --> 00:20:53,500
+ال multi-threading احنا في ال collections هنركز
+
+267
+00:20:53,500 --> 00:21:00,790
+على ال unrealist هنركز على ال unrealistطيب من ال
+
+268
+00:21:00,790 --> 00:21:04,130
+array list interface أو عفوًا ال class أنا عندي
+
+269
+00:21:04,130 --> 00:21:10,310
+add و size و get add من اسمها تعمل إضافة لعنصر على
+
+270
+00:21:10,310 --> 00:21:15,390
+ال list يعني بروح بقوله ال list تبعتي او ال array
+
+271
+00:21:15,390 --> 00:21:24,430
+list dot add read الان أول element read dot add
+
+272
+00:21:24,430 --> 00:21:26,350
+white
+
+273
+00:21:27,830 --> 00:21:33,310
+الـ element التاني هيكون white size بترجعلي بحجم
+
+274
+00:21:33,310 --> 00:21:35,350
+ال list كام element في ال list الموجودة بترجع ب
+
+275
+00:21:35,350 --> 00:21:41,670
+integer get بترجع ب object من ال list اللي عندي
+
+276
+00:21:41,670 --> 00:21:47,850
+حسب ال index المُعضَى حسب ال index المُعضَى وبما
+
+277
+00:21:47,850 --> 00:21:51,930
+أن ال array list هي عبارة عاملة implementation لل
+
+278
+00:21:51,930 --> 00:21:56,430
+collection interface معناته أنا فيه عندي contents
+
+279
+00:21:58,540 --> 00:22:04,660
+بوليان فانكشن بترجع
+
+280
+00:22:04,660 --> 00:22:08,480
+بـ true لما بتكون ال element موجود زي ما شوفنا مع
+
+281
+00:22:08,480 --> 00:22:12,460
+ال folder و ال file مع ال file is a file is exist
+
+282
+00:22:12,460 --> 00:22:16,300
+او exist مظبوط الآن ال method التاني اسمها
+
+283
+00:22:16,300 --> 00:22:20,960
+iterator عشان ترجعلي ب iterator object على ال
+
+284
+00:22:20,960 --> 00:22:24,760
+lists اللي موجودة عندى هان ال iterator object
+
+285
+00:22:24,760 --> 00:22:31,320
+هيكون فيه عندىالـ main method هدول has next بوليان
+
+286
+00:22:31,320 --> 00:22:33,420
+function عشان تتأكد دائما في element في ال
+
+287
+00:22:33,420 --> 00:22:38,540
+iterator next عشان تعمل obtain لل current element
+
+288
+00:22:38,540 --> 00:22:41,540
+في ال iterator و remove تعمل remove لل current
+
+289
+00:22:41,540 --> 00:22:50,540
+element على ال iterator اللي موجود عندها نعم؟ تخيل
+
+290
+00:22:50,540 --> 00:22:51,160
+ال iterator
+
+291
+00:23:01,380 --> 00:23:08,920
+بدأت color list ولا array اللي فوق خالص اللي هي ال
+
+292
+00:23:08,920 --> 00:23:13,880
+colors array فيها تلت ألوان لأن أعرفت array list
+
+293
+00:23:13,880 --> 00:23:18,640
+هي color list سميتها array list من نوع string طب و
+
+294
+00:23:18,640 --> 00:23:21,640
+لاحظوا السطر اللي معموله ال comment فوق إيش نوعه
+
+295
+00:23:21,640 --> 00:23:27,900
+list correct أو color list equal new array list من
+
+296
+00:23:27,900 --> 00:23:33,500
+ال string لاحظوا إن في البدايةلازم اعرف ال data
+
+297
+00:23:33,500 --> 00:23:38,040
+type معاها، تمام؟ طيب السؤال ال commented line صح
+
+298
+00:23:38,040 --> 00:23:49,800
+ولا غلط؟ ال commented line هذا صح ولا غلط؟ ايوة،
+
+299
+00:23:49,800 --> 00:23:53,460
+هذه عبارة عن subclass من ال list وبالتالي العلاقة
+
+300
+00:23:53,460 --> 00:23:57,660
+بينهم is a وبالتالي مافيش فيها مشكلة، ال line صحيح
+
+301
+00:23:57,660 --> 00:24:07,110
+مئة في المئة، تمامبدي أضيف عناصر ال array على ال
+
+302
+00:24:07,110 --> 00:24:09,650
+list اللي موجودة عندي هنا ممكن أعمل ال loop
+
+303
+00:24:09,650 --> 00:24:15,030
+العادية iterator i equals 0 أقل من ال length من
+
+304
+00:24:15,030 --> 00:24:21,370
+تبع ال color بس plus color list dot add ال colors
+
+305
+00:24:21,370 --> 00:24:26,470
+of i طريقة تانية ممكن أروح أعمل for
+
+306
+00:24:32,270 --> 00:24:39,370
+string s في مين؟ أو الـ C في ال killers صح؟ ماشي
+
+307
+00:24:39,370 --> 00:24:46,690
+راح أقوله ال dot add ال C أو ال S مش قضية كتير
+
+308
+00:24:46,690 --> 00:24:49,470
+وبالتالي يعني اللوب هذا يقدر يعملها implementation
+
+309
+00:24:49,470 --> 00:24:53,690
+بال 4H contains
+
+310
+00:24:53,690 --> 00:24:57,280
+قلنا بترجع ب trueلو كان ال color موجود او لو كان
+
+311
+00:24:57,280 --> 00:25:00,760
+ال object موجود ال color list dot contains it true
+
+312
+00:25:00,760 --> 00:25:06,220
+white هترجع ب false نفي ال false true يعني لو كان
+
+313
+00:25:06,220 --> 00:25:13,700
+اللون مش موجود اضيفه لو
+
+314
+00:25:13,700 --> 00:25:17,460
+انا بدى اطبع ال array او ال array list اللى عندى
+
+315
+00:25:17,460 --> 00:25:22,160
+ممكن اطبعهم element element بناء على ال index و ال
+
+316
+00:25:22,160 --> 00:25:24,560
+size تبعتها لحظة انا ماتكلمتش على ال iterator لحد
+
+317
+00:25:24,560 --> 00:25:25,020
+اللحظة
+
+318
+00:25:28,470 --> 00:25:32,510
+ممكن اعتمد على ال 4H بداخل ال array list زي ما
+
+319
+00:25:32,510 --> 00:25:35,170
+كتبته قبل شوية مع ال array اللى موجودة عندى مافيش
+
+320
+00:25:35,170 --> 00:25:42,750
+مشكلة وممكن استفيد من ال iterator العرف iterator
+
+321
+00:25:42,750 --> 00:25:47,570
+object على string iterator object على string يساوي
+
+322
+00:25:47,570 --> 00:25:53,180
+color list dot iteratorwhile الـ iterator dot has
+
+323
+00:25:53,180 --> 00:25:57,680
+next مابهمنيش العدد جديش ولان مافيه element بدياهو
+
+324
+00:25:57,680 --> 00:26:01,320
+مانعيش كلهم system dot out dot print line
+
+325
+00:26:01,320 --> 00:26:04,660
+literator dot next عشان احصل على القيمة الموجودة
+
+326
+00:26:04,660 --> 00:26:08,340
+بالمناسبة لو احنا عملنا system dot out dot print
+
+327
+00:26:08,340 --> 00:26:15,940
+line او dot print ل ال colors فوق ايش ال output؟
+
+328
+00:26:15,940 --> 00:26:18,060
+هاي ال colors
+
+329
+00:26:21,520 --> 00:26:26,280
+أيوة بتديني ال reference address بتقولها طيب لو
+
+330
+00:26:26,280 --> 00:26:37,980
+أنا راح قلتله print ال color list نفس
+
+331
+00:26:37,980 --> 00:26:47,860
+الأشياء لأ هأضعلك الريب الشكل هذا red كما blue
+
+332
+00:26:47,860 --> 00:26:51,200
+green احنا حطيناه في البداية
+
+333
+00:26:54,640 --> 00:27:00,580
+green blue و white وهذا الفرق الأساسي بين ال array
+
+334
+00:27:00,580 --> 00:27:06,760
+و ال list لأنه في مجال أن أشوف ال data اللي موجودة
+
+335
+00:27:06,760 --> 00:27:10,720
+في الداخل ال list as one shot كأنها one element
+
+336
+00:27:10,720 --> 00:27:15,560
+أنا بأتعامل معاه طيب
+
+337
+00:27:15,560 --> 00:27:20,220
+في
+
+338
+00:27:20,220 --> 00:27:24,180
+طريقة تانية اللي حكيناها قبل شويةاللي هي arrays
+
+339
+00:27:24,180 --> 00:27:29,760
+.asList الـ arrays class في method aesthetic
+
+340
+00:27:29,760 --> 00:27:34,480
+method اسمها asList بترجع ب object من نوع list
+
+341
+00:27:34,480 --> 00:27:38,520
+وبالتالي أنا بقدر أستفيد منه أستفيد من ال array ..
+
+342
+00:27:38,520 --> 00:27:42,180
+من ال arrays.asList عشان أضيف ال element مرة واحدة
+
+343
+00:27:42,180 --> 00:27:44,980
+بدل ما أضيفهم element element من خلال .. أولا هقول
+
+344
+00:27:44,980 --> 00:27:49,820
+له ال list تبعتي بدأت ساوي arrays.asList colors
+
+345
+00:27:49,820 --> 00:27:55,620
+صارت في عندي listو أروح أستخدم ال list هذه as
+
+346
+00:27:55,620 --> 00:28:01,100
+argument لل constructor تبعت ال array list أو ممكن
+
+347
+00:28:01,100 --> 00:28:08,720
+بشكل مباشر أجيب ال line هذا بدون
+
+348
+00:28:08,720 --> 00:28:15,140
+ال semi colon طبعا و أجيبه مباشر أحطه مكان ال list
+
+349
+00:28:15,140 --> 00:28:17,840
+اللي عندي هان و بصير مباشر أخد كل عناصر ال array
+
+350
+00:28:17,840 --> 00:28:22,070
+بدون مضطر أكتب ال codeالطويل السابق اللي احنا
+
+351
+00:28:22,070 --> 00:28:26,790
+شوفناه قبل شوية هي
+
+352
+00:28:26,790 --> 00:28:31,990
+فعليا arrays as list عملت عاملة implementation
+
+353
+00:28:31,990 --> 00:28:34,590
+تماما لل code اللي احنا كتبناه قبل شوية عاملة
+
+354
+00:28:34,590 --> 00:28:38,170
+iterator او عاملة loop على عناصر ال array واضفتهم
+
+355
+00:28:38,170 --> 00:28:40,670
+بالترتيب السابق اللي احنا شوفناه
+
+356
+00:28:46,180 --> 00:28:49,540
+شوفنا الـ ArrayList وشوفنا الـ methods add و get و
+
+357
+00:28:49,540 --> 00:28:54,420
+contains و iterator مجموعة الـ method بما أن هذه
+
+358
+00:28:54,420 --> 00:28:59,240
+عاملة implementation ل ال collection class وفي
+
+359
+00:28:59,240 --> 00:29:02,980
+قلنا ال collections عاملة implementation ل ال
+
+360
+00:29:02,980 --> 00:29:06,460
+collection interface ال collection interface وقلنا
+
+361
+00:29:06,460 --> 00:29:10,360
+في عنا collection class collections class عامل
+
+362
+00:29:10,360 --> 00:29:13,730
+implementation ل الالـ interface اللي موجود عندى
+
+363
+00:29:13,730 --> 00:29:16,610
+وفيه عندى مجموعة من الـ static methods اللي ممكن
+
+364
+00:29:16,610 --> 00:29:23,510
+أنا أستفيد منها sort
+
+365
+00:29:23,510 --> 00:29:32,010
+يعني الأن هقول ال collections dot
+
+366
+00:29:32,010 --> 00:29:40,490
+sort عشان نكون واضحين من البداية لوالـ code أو
+
+367
+00:29:40,490 --> 00:29:46,170
+السؤال اللي جاكي كان بيقولك صحح الخطأ و كنت كاتب
+
+368
+00:29:46,170 --> 00:29:50,510
+لك collection تمام؟
+
+369
+00:29:50,510 --> 00:29:54,450
+انت مسئول اتحدد الخطأ هذا تمام؟ لكن لو قلت في
+
+370
+00:29:54,450 --> 00:29:57,790
+أثناء الامتحان قلت لك اكتبي code عشان تعملي صورة
+
+371
+00:29:57,790 --> 00:30:03,680
+القرية لو كتبت و نسيت ال Sأنا ممكن إيش؟ أمشيها
+
+372
+00:30:03,680 --> 00:30:08,100
+لأنه بفترض و للأسف هذا اللي بيصير أن معظمنا بيعتمد
+
+373
+00:30:08,100 --> 00:30:13,780
+على ال compiler يحددله الأخطاء فانت بدك تنتبه إذا
+
+374
+00:30:13,780 --> 00:30:18,000
+كان السؤال بيقول حدد الخطأمعناته بيتنتبهي للأسس
+
+375
+00:30:18,000 --> 00:30:21,920
+هذه مش تقولي والله الدكتور مابرحمش لاحقا لأ حسب
+
+376
+00:30:21,920 --> 00:30:25,000
+السؤال بيتتعاملي معاه لكن بوعدك إذا كانت السؤال
+
+377
+00:30:25,000 --> 00:30:28,300
+كتابة code و ال code اللي فيه طويل و محتاج يعني
+
+378
+00:30:28,300 --> 00:30:31,320
+تركيز عالي ممكن أسامح هنا في بعض الأخطاء اللي
+
+379
+00:30:31,320 --> 00:30:35,480
+املاقية أثناء الكتابة طيب collections قولنا that
+
+380
+00:30:35,480 --> 00:30:40,940
+sort إيش بتساوي تعمل ترتيب للعناصر ترتيب بناء على
+
+381
+00:30:40,940 --> 00:30:46,930
+إيش؟مباشرة مايخطرش على بالك إلا غير ترتيب Alpha
+
+382
+00:30:46,930 --> 00:30:51,410
+Numeric فقط إذا كل ال data اللي موجودة عند ال
+
+383
+00:30:51,410 --> 00:30:54,230
+string معناته بتتكلم على alphabetical ordering طب
+
+384
+00:30:54,230 --> 00:30:58,250
+تصعدي ولا تنازلي؟ لأ تصعدي، ترتيب by default
+
+385
+00:30:58,250 --> 00:31:04,590
+تصعدي، طب بتعمل ترتيب تنازلي؟ مافيشش، آه ال
+
+386
+00:31:04,590 --> 00:31:09,270
+reverse هي يا أستاذ اللي شدت نظرك هي بتعمل reverse
+
+387
+00:31:09,270 --> 00:31:13,040
+لل element يعني القارية تبعتي مثلا، فيها redو فيها
+
+388
+00:31:13,040 --> 00:31:17,720
+green و فيها blue إذا أنا قلتله reverse هتصير blue
+
+389
+00:31:17,720 --> 00:31:24,080
+green و red أنا بدي descending order sorting
+
+390
+00:31:24,080 --> 00:31:28,840
+descending sorting إيش بدي أساوي؟ بدي أروح أقوله
+
+391
+00:31:28,840 --> 00:31:33,480
+في الأول sort هيرتبلي إياها ترتيب تصعدي بعد هيك
+
+392
+00:31:33,480 --> 00:31:37,320
+إيش راح أقوله؟ أقول له أعملها reverse بروح بنعملي
+
+393
+00:31:37,320 --> 00:31:41,040
+إياها تنازلي فانا محتاج تجري ل two methods بالشكل
+
+394
+00:31:41,040 --> 00:31:47,280
+هذاbinary search مرت عليكي في ال data structure ان
+
+395
+00:31:47,280 --> 00:31:50,600
+ال array list هذه العناصر فيها مرتبة ترتيب sorted
+
+396
+00:31:50,600 --> 00:31:56,340
+ترتيب تصعدي وعملية ال search بتعتمد على halving ان
+
+397
+00:31:56,340 --> 00:32:00,240
+اجسم دائما ال list لرصين عشان اعمل skip لواحد من
+
+398
+00:32:00,240 --> 00:32:03,800
+ال half اللي موجودين عندى جولنا ال reverse ان انا
+
+399
+00:32:03,800 --> 00:32:05,920
+اروح اعمل reverse to the element of the list
+
+400
+00:32:05,920 --> 00:32:11,880
+shuffleترتيب عشوائي اعيد ترتيب العناصر ترتيب
+
+401
+00:32:11,880 --> 00:32:17,260
+عشوائي fill اعبّ القراية طبعا كمان مرة collections
+
+402
+00:32:17,260 --> 00:32:21,860
+dot
+
+403
+00:32:21,860 --> 00:32:28,180
+fill هذه هتاخد مني two objects او تاخد مني two
+
+404
+00:32:28,180 --> 00:32:34,070
+objects الأول اللي هي ال list تبعتنا والتانيالـ
+
+405
+00:32:34,070 --> 00:32:37,530
+object اللي أنا بدي أقعد بيه أضيفه تخيلي مثلا
+
+406
+00:32:37,530 --> 00:32:45,510
+white أو بلاش black عارفة
+
+407
+00:32:45,510 --> 00:32:48,990
+إيش هتصير في ال list اللي عندي هان؟ كل العناصر
+
+408
+00:32:48,990 --> 00:32:53,770
+اللي فيها هتصير black جداش هتضيف كام element؟ طب
+
+409
+00:32:53,770 --> 00:33:01,030
+لو كانت ال list فاضية مش هيعمل حاجةمش هيقدر يعبيها
+
+410
+00:33:01,030 --> 00:33:04,530
+ليش لأنه فعليا هو أنا جاعة بقوله fill فعشان ي fill
+
+411
+00:33:04,530 --> 00:33:07,570
+لازم يعمل list plus يكون already exist من خلال ال
+
+412
+00:33:07,570 --> 00:33:13,650
+add method اللي موجود عندها copy بنسخ
+
+413
+00:33:13,650 --> 00:33:18,190
+reference من list ل element ل list تانية minimum و
+
+414
+00:33:18,190 --> 00:33:23,910
+maximum معروفات add all يجيب كل العناصر اللي في
+
+415
+00:33:23,910 --> 00:33:29,020
+listويعملهم append لل list الموجودة عندي frequency
+
+416
+00:33:29,020 --> 00:33:34,800
+عشان يرجع ب number انتجة كم مرة ال element هذا
+
+417
+00:33:34,800 --> 00:33:39,760
+موجود في ال list كم مرة ال element هذا موجود في ال
+
+418
+00:33:39,760 --> 00:33:43,600
+list ولو كان في عندي two lists وبدأ أسأل هل في
+
+419
+00:33:43,600 --> 00:33:46,920
+بينهم تقاطع أو لأ؟ في عناصر مشتركة بينهم أو لأ؟
+
+420
+00:33:46,920 --> 00:33:53,420
+ممكن ألجأ للمتد اسمها disjoint بدي تنتبه أنه دائما
+
+421
+00:33:54,990 --> 00:34:00,490
+هذه الـ methods مابتعملش return مابتعملش return
+
+422
+00:34:00,490 --> 00:34:04,230
+مابتعملش
+
+423
+00:34:04,230 --> 00:34:11,610
+return مابتعملش return مابتعملش return مابتعملش
+
+424
+00:34:11,610 --> 00:34:12,010
+return مابتعملش return مابتعملش return مابتعملش
+
+425
+00:34:12,010 --> 00:34:12,230
+return مابتعملش return مابتعملش return مابتعملش
+
+426
+00:34:12,230 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+427
+00:34:12,250 --> 00:34:12,390
+return مابتعملش return مابتعملش return مابتعملش
+
+428
+00:34:12,390 --> 00:34:19,750
+return مابتعملش return
+
+429
+00:34:19,750 --> 00:34:24,490
+مابأنا هيك بقوله collections.sort و بتديه الـ
+
+430
+00:34:24,490 --> 00:34:28,390
+killer list التقييم مباشرة الالمتحدث ان عمل ترتيب
+
+431
+00:34:28,390 --> 00:34:33,470
+لمين للعناصر في داخل الـ array يعني انت لو طبعتها
+
+432
+00:34:33,470 --> 00:34:40,130
+جبل و طبعتها بعد تمام مباشرة هتلاقيها جبل جبل عملت
+
+433
+00:34:40,130 --> 00:34:43,290
+ال sort كانت غير مرتبة و بعد ال sort تم ترتيبها
+
+434
+00:34:43,290 --> 00:34:44,310
+ترتيب تصعدي
+
+435
+00:34:51,250 --> 00:34:55,850
+الـ set ال
+
+436
+00:34:55,850 --> 00:35:00,750
+class التاني بتفرج عن ال array list على أنها
+
+437
+00:35:00,750 --> 00:35:09,190
+unordered collection of unique elements، unordered
+
+438
+00:35:09,190 --> 00:35:16,020
+طيب، بدياك تنتبه لكلمة ordered و unorderedغاد
+
+439
+00:35:16,020 --> 00:35:19,600
+قولنا ال order يعني الآن تخيل ال list ال first
+
+440
+00:35:19,600 --> 00:35:26,300
+position ال second ال third ال fourth إلى آخره
+
+441
+00:35:26,300 --> 00:35:31,460
+هدولة بالنسبالك معروفات بناء على إيش؟ بناء على ال
+
+442
+00:35:31,460 --> 00:35:35,660
+add بناء على ال push اللي صوتيها للعناصر اللي
+
+443
+00:35:35,660 --> 00:35:40,380
+موجودة عندها وعشان هات قولت ordered بينما .. بينما
+
+444
+00:35:40,380 --> 00:35:47,750
+لو كانت عندي set وروحت قولت لل set.add وقلت له red
+
+445
+00:35:47,750 --> 00:35:54,990
+object ووراها green ووراها blue مش ضروري يطلع ليهم
+
+446
+00:35:54,990 --> 00:36:00,250
+نفس الترتيب عشان إيه قلت عنها unordered لو أنا
+
+447
+00:36:00,250 --> 00:36:07,350
+أضفت ال read كمان مرة مش هيقبله مدنيش syntax error
+
+448
+00:36:07,350 --> 00:36:12,130
+هو بياخد ال object و بروح بده يعمله add إذا هو
+
+449
+00:36:12,130 --> 00:36:17,520
+existخلاص موجود does not exist بيضيفه على عناصر ال
+
+450
+00:36:17,520 --> 00:36:20,600
+array اللي موجودة عندها ال implementation تبعت ال
+
+451
+00:36:20,600 --> 00:36:26,780
+set ها اما من ال hash set او tree set اما hash set
+
+452
+00:36:26,780 --> 00:36:33,120
+او tree set ايش الفرق بينهم؟ ايش ال hashing؟
+
+453
+00:36:33,120 --> 00:36:35,680
+معناته ال hashing هي عبارة عن schema او algorithm
+
+454
+00:36:35,680 --> 00:36:41,980
+تمام الفكرة فيه انه يعمل place لل items يضيفهم
+
+455
+00:36:42,740 --> 00:36:51,000
+اضيفهم وين على index بتتم تحديده من ال element
+
+456
+00:36:51,000 --> 00:36:54,580
+نفسه يعني لو مانا في الدياجي أقولك أنا عندي مجموعة
+
+457
+00:36:54,580 --> 00:37:06,220
+من الأسماء أحمد و خالد و .. بس لحظة شوية اه مش
+
+458
+00:37:06,220 --> 00:37:11,960
+collection في الآخر بس اصبر شوية اه اصبر اصبر بهاء
+
+459
+00:37:13,740 --> 00:37:22,500
+و رائد مثلا و أضفت هدول لست أضفت هدول لست بناء على
+
+460
+00:37:22,500 --> 00:37:29,100
+hash function تمام تحدد ال position بناء على عدد
+
+461
+00:37:29,100 --> 00:37:36,400
+ال characters بناء على عدد ال characters بهاء خمسة
+
+462
+00:37:36,400 --> 00:37:41,560
+أحمد أو خالد ستة أحمد خمسة رائد أربعة يعني انه
+
+463
+00:37:41,560 --> 00:37:42,300
+رائد في الأول
+
+464
+00:37:46,340 --> 00:37:52,320
+الان بهاء و أحمد نفس الأشياء الأولوية اللي ظهر في
+
+465
+00:37:52,320 --> 00:37:57,440
+الأول و
+
+466
+00:37:57,440 --> 00:38:03,540
+بعدين بتجيبلي خالد هذا بناء على إيش؟ بناء على الـ
+
+467
+00:38:03,540 --> 00:38:06,820
+string length لكن ممكن تكون ال hash code مبنية
+
+468
+00:38:06,820 --> 00:38:11,760
+بناء alphabetical هتروح تحقق ليه بهاء أو أحمد بهاء
+
+469
+00:38:11,760 --> 00:38:16,260
+خالدرائد، حسب إيش الـ hash core الـ function تبعتي
+
+470
+00:38:16,260 --> 00:38:19,460
+اللي موجودة، ممكن يكون في عندي hash function تانية
+
+471
+00:38:19,460 --> 00:38:22,860
+تبني بناءً على ال summation تبعتي ال binary value
+
+472
+00:38:22,860 --> 00:38:27,580
+لكل character، تمام؟ فحسب إيش ال hashing اللي أنا
+
+473
+00:38:27,580 --> 00:38:31,700
+بتقدر، في الآخر بتعمل generate لمين؟ لل index،
+
+474
+00:38:31,700 --> 00:38:34,960
+عشان أحدد ال position تبعتي، الآن، هل ال index
+
+475
+00:38:34,960 --> 00:38:39,980
+اللي تم إنشاه وأنا بقدر استفيد منه؟ لأالـ Index
+
+476
+00:38:39,980 --> 00:38:44,920
+موجود نعم لكنه من خلال الـ hash code تمام؟ ففيش
+
+477
+00:38:44,920 --> 00:38:48,820
+مجال أروح أستخدم صفر و واحد و اتنين اللي أنا
+
+478
+00:38:48,820 --> 00:38:54,340
+بعرفهم لأ لأ لأ هذا مع ال order لأن ال locationهو
+
+479
+00:38:54,340 --> 00:38:58,260
+اللي له الـ index تمام؟ بينما ال location هذا تم
+
+480
+00:38:58,260 --> 00:39:01,760
+تحديده أو تم تحديد ال address .. ال index بتاعته
+
+481
+00:39:01,760 --> 00:39:04,180
+بناءًا على مين؟ بناءًا على ال hash function اللي
+
+482
+00:39:04,180 --> 00:39:07,440
+موجود ده عندي وبالتالي بقدرش .. أنا مش عارف إيش ال
+
+483
+00:39:07,440 --> 00:39:10,220
+output تبعت ال hash function عشان أقدر أعتمد على
+
+484
+00:39:10,220 --> 00:39:15,260
+مين؟ على ال index اللي عندي فال index موجود، هل
+
+485
+00:39:15,260 --> 00:39:20,640
+أستفيد منه؟ طيب، الآن .. وبالتالي أنا فيه عندي
+
+486
+00:39:20,640 --> 00:39:26,150
+hashingفي عندي hash code ال hash code في ال system
+
+487
+00:39:26,150 --> 00:39:31,030
+عندي هي عبارة عن integer value تم حسابتها بناء على
+
+488
+00:39:31,030 --> 00:39:34,970
+ال object اللي هم زي ما قلنا قبل شوية و المفروض ان
+
+489
+00:39:34,970 --> 00:39:39,350
+ال different object تديني different hash code عشان
+
+490
+00:39:39,350 --> 00:39:42,090
+مايصيرش في عندي duplication و في عندي .. يصير في
+
+491
+00:39:42,090 --> 00:39:45,290
+عندي two elements في نفس ال .. نفس الم .. نفس ال
+
+492
+00:39:45,290 --> 00:39:48,610
+location او نفس ال place لان أحيانا بصير في عندي
+
+493
+00:39:48,610 --> 00:39:54,050
+collision لما بكون في عندي different objectوطلع
+
+494
+00:39:54,050 --> 00:39:57,310
+لهم نفس الـ hash code يعني .. أجي أقول .. زي ما
+
+495
+00:39:57,310 --> 00:40:03,470
+قلنا قبل شوية عندي أحمد و بهق تمام؟ لو كنت باعتمد
+
+496
+00:40:03,470 --> 00:40:08,550
+على عدد ال characters التنب طلع لهم خمسة أصبت؟ طب
+
+497
+00:40:08,550 --> 00:40:10,850
+معناه أن التنب دول بيكونوا في نفس ال position هانا
+
+498
+00:40:10,850 --> 00:40:13,350
+حابب أسميه إيه اللي صار في عندي؟ collision بحيث أن
+
+499
+00:40:13,350 --> 00:40:18,130
+ال two different objects طلع لهم same hash code
+
+500
+00:40:18,130 --> 00:40:23,700
+طبعا المفروض أن ال hash function الجيدةالـ hash
+
+501
+00:40:23,700 --> 00:40:27,440
+function الجيدة دائماً عدد الـ collection فيها
+
+502
+00:40:27,440 --> 00:40:33,000
+منخفض جداً من الأمثلة الفعالة جداً في موضوع الـ
+
+503
+00:40:33,000 --> 00:40:37,960
+hash code اللي بناخد عليها رقم الهوية أو الرقم
+
+504
+00:40:37,960 --> 00:40:42,760
+الوطني هو كيف بنعملها validation وهذه الشيء التاني
+
+505
+00:40:42,760 --> 00:40:46,460
+في الـ hash code المفروض إن الـ hash code هذا أقدر
+
+506
+00:40:46,460 --> 00:40:50,900
+من خلاله أصل ال data الحقيقية لما أعمل reverse
+
+507
+00:40:51,870 --> 00:40:55,850
+Engineering للـ code اللي موجود عندى anyway ففي
+
+508
+00:40:55,850 --> 00:41:00,010
+الآخر هذا هو ال hash code في عندى ال hash table هو
+
+509
+00:41:00,010 --> 00:41:05,450
+ال position او هو الجدول اللى بيبنى على مين على ال
+
+510
+00:41:05,450 --> 00:41:09,890
+hash code و ال index تبعته بتكون هي عبارة عن ال
+
+511
+00:41:09,890 --> 00:41:13,850
+hash code اللى موجود عندى عشان اضيفه طبعا في عندى
+
+512
+00:41:13,850 --> 00:41:18,950
+ال load factor جدش في عندى data موجودة وجدش في
+
+513
+00:41:18,950 --> 00:41:24,990
+عندى ال ratio بينعدد الخلايا الموجودة في الـ hash
+
+514
+00:41:24,990 --> 00:41:31,070
+table وعدد الخلايا المستخدمة من الجدول على عدد
+
+515
+00:41:31,070 --> 00:41:34,930
+الخلايا الكلي بنسميها ال load factor وليس قضية
+
+516
+00:41:34,930 --> 00:41:37,870
+كتير هيديلها علاقة بال performance كده ال hash
+
+517
+00:41:37,870 --> 00:41:41,790
+code تبعتي بتعمل generate صح أو allocation صح
+
+518
+00:41:41,790 --> 00:41:45,610
+للعناصر anyway تعالى نشوف بال Java بال code تبعنا
+
+519
+00:41:46,560 --> 00:41:49,420
+array list أو a b c array عبارة عن array of string
+
+520
+00:41:49,420 --> 00:41:51,740
+فيها مجموعة من ال characters ال b و ال c
+
+521
+00:41:51,740 --> 00:41:56,200
+duplicated values أنا روحت عرفت array list في
+
+522
+00:41:56,200 --> 00:42:00,640
+البداية اللي حشوفناها في الكود السابق و أضفت ال
+
+523
+00:42:00,640 --> 00:42:05,100
+array تبعتيها لل array list و روحت طبعتها مباشرة
+
+524
+00:42:05,100 --> 00:42:11,020
+هيطبعلي ال array list مثل ما أضفتها تماما ordered
+
+525
+00:42:11,020 --> 00:42:13,920
+و تسمح بال duplication هي ال list
+
+526
+00:42:17,800 --> 00:42:25,080
+عملت set هاش set وأضفت لها ال array list تبعتي أو
+
+527
+00:42:25,080 --> 00:42:27,500
+ال array عفوا اللي عندي أو ال array list فاش مشكلة
+
+528
+00:42:27,500 --> 00:42:34,980
+عندي وروحت طبعتها مباشرة إيش تتوقعي؟ أول حاجة مش
+
+529
+00:42:34,980 --> 00:42:39,830
+هيكون في duplication الشغل التاني الترتيبالترتيب
+
+530
+00:42:39,830 --> 00:42:42,450
+حسب الـ hash function حسب الـ hash function
+
+531
+00:42:42,450 --> 00:42:45,770
+المعتمدة الجافة في ال output اللي عندي فاطلع لي a
+
+532
+00:42:45,770 --> 00:42:50,370
+b c d e هيك أنا بفهم ان ال hash function اعتمدت
+
+533
+00:42:50,370 --> 00:42:56,310
+على ال alphabetical او alphabetical schema لترتيب
+
+534
+00:42:56,310 --> 00:43:00,930
+ال data اللي موجود عندها بقى عندي اخر شغلة خلال
+
+535
+00:43:00,930 --> 00:43:03,630
+دقيقة ان شاء الله بنخلصها و لو اضطرنا بنرجع لها
+
+536
+00:43:03,630 --> 00:43:09,100
+مرة تانية الآن بما انهبشكل أو باخر بدي أعمل
+
+537
+00:43:09,100 --> 00:43:11,880
+implementation للـ tree أو للـ set اللي موجودة
+
+538
+00:43:11,880 --> 00:43:16,060
+عندي هان قولنا احنا اما ب hash code او hash
+
+539
+00:43:16,060 --> 00:43:20,460
+function او hash set او tree set ايش مفهوم الـ
+
+540
+00:43:20,460 --> 00:43:23,800
+tree؟ انا بتكلم على مجموعة من الباخذ و لا لأ من
+
+541
+00:43:23,800 --> 00:43:28,960
+المسارات فالـ tree هي لازم تكون sorted مفهوم الـ
+
+542
+00:43:28,960 --> 00:43:33,060
+tree دائما إذا أنا بتكلم على ال roadالـ value اللي
+
+543
+00:43:33,060 --> 00:43:37,360
+على اليسار أقل والـ value اللي على اليمين أكبر
+
+544
+00:43:37,360 --> 00:43:41,160
+سواء كنت بتكلم على binary tree أو غيرها ففي الآخر
+
+545
+00:43:41,160 --> 00:43:50,040
+هتكون في عندي sorted وفعليا حتى ال hash ممكن أحصل
+
+546
+00:43:50,040 --> 00:43:52,740
+على sorted حسب ال scheme ال hash code ال hash
+
+547
+00:43:52,740 --> 00:43:56,580
+function اللي موجودة عندها طيب إذا كانت ال data
+
+548
+00:43:56,580 --> 00:44:01,070
+sortedفي الـ Tree اللي عندي معناته أنا بقدر ..
+
+549
+00:44:01,070 --> 00:44:04,810
+طبعا إذا كنت استخدمت الـ Tree set object عشان أنشئ
+
+550
+00:44:04,810 --> 00:44:08,770
+ال set تبعتي في عندي شغل اسمها ال head set و ال
+
+551
+00:44:08,770 --> 00:44:13,590
+tail set بالإضافة لل first و ال last ال method
+
+552
+00:44:13,590 --> 00:44:18,790
+الأولى ال head set بترجع ب subset تمام اللي موجودة
+
+553
+00:44:18,790 --> 00:44:24,730
+قبل يعني تخيلي A,B,C,D,E هاي العناصر اللي موجودة
+
+554
+00:44:24,730 --> 00:44:29,400
+عندي هنا و ال F يكنو جيت و قلت لك بدي الـ sub أو
+
+555
+00:44:29,400 --> 00:44:33,220
+الـ tail set لل set اللي موجود هذا بناء على ال D
+
+556
+00:44:33,220 --> 00:44:42,500
+هذه ال function هذه ABC بمثله head set المجموع
+
+557
+00:44:42,500 --> 00:44:46,860
+اللي هي sub set المجموع القبل وال tail set من ال D
+
+558
+00:44:46,860 --> 00:44:52,630
+للآخربتحتوى الـ D طب و ال first و ال last ال first
+
+559
+00:44:52,630 --> 00:44:55,130
+element و ال last element اللي موجودين على ال tree
+
+560
+00:44:55,130 --> 00:44:57,630
+تعالى نشوف ال code هذا على السريع المحاضرة الجاية
+
+561
+00:44:57,630 --> 00:45:01,670
+ان شاء الله تعالى لأن الوقت أدركنا بنبدأ من عند ال
+
+562
+00:45:01,670 --> 00:45:04,310
+sets و بنتكلم على ال tree set ان شاء الله تبارك
+
+563
+00:45:04,310 --> 00:45:07,910
+وتعالى تي اي سؤال يا بنات؟ بيبقى سهل ال tree set
+
+564
+00:45:07,910 --> 00:45:10,250
+انا بحدد من وين و من كده بناء على ال character
+
+565
+00:45:10,250 --> 00:45:12,970
+اللي بتحدي دي نعم الله تكل عافية
+
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.json b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..6bef7e8c4e9eb59e67e2d32721fccadb89b0b3d8
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.json
@@ -0,0 +1 @@
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{"start": 72.41, "end": 72.51, "word": " ال", "probability": 0.99560546875}, {"start": 72.51, "end": 72.85, "word": " object", "probability": 0.9833984375}, {"start": 72.85, "end": 73.01, "word": " اللي", "probability": 0.98486328125}, {"start": 73.01, "end": 73.11, "word": " أنا", "probability": 0.349609375}, {"start": 73.11, "end": 73.35, "word": " ممكن", "probability": 0.9921875}, {"start": 73.35, "end": 74.29, "word": " أشيرله؟", "probability": 0.803369140625}], "temperature": 1.0}, {"id": 3, "seek": 9980, "start": 74.62, "end": 99.8, "text": "أي object أبسطها الـ string اللي بنعرفه لك ممكن يكون ال collection عنده collection of employees collection of cars collection of students حسب ال data type اللي موجودة وبالتالي ال object هذا ممكن يكون من أي type is a relationship يعني أنا فيه عندي employee", "tokens": [10721, 1829, 2657, 5551, 3555, 3794, 9566, 11296, 2423, 39184, 6798, 13672, 1829, 44945, 3615, 28480, 3224, 5296, 4117, 3714, 43020, 7251, 30544, 2423, 5765, 43242, 3224, 5765, 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82.46, "end": 82.84, "word": " of", "probability": 0.97119140625}, {"start": 82.84, "end": 83.3, "word": " students", "probability": 0.94189453125}, {"start": 83.3, "end": 83.92, "word": " حسب", "probability": 0.962890625}, {"start": 83.92, "end": 84.06, "word": " ال", "probability": 0.962890625}, {"start": 84.06, "end": 84.18, "word": " data", "probability": 0.9638671875}, {"start": 84.18, "end": 84.54, "word": " type", "probability": 0.9375}, {"start": 84.54, "end": 84.8, "word": " اللي", "probability": 0.9541015625}, {"start": 84.8, "end": 85.84, "word": " موجودة", "probability": 0.989501953125}, {"start": 85.84, "end": 88.54, "word": " وبالتالي", "probability": 0.9392578125}, {"start": 88.54, "end": 89.18, "word": " ال", "probability": 0.9287109375}, {"start": 89.18, "end": 90.28, "word": " object", "probability": 0.94970703125}, {"start": 90.28, "end": 90.64, "word": " هذا", "probability": 0.75732421875}, {"start": 90.64, "end": 90.92, "word": " ممكن", "probability": 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"start": 100.76, "end": 124.06, "text": "وفي عندي part-time employee وفي عندي full-time employee، مظبوط؟ إيش العلاقة بينهم؟ ال part-time employee is a employee و ال full-time is an employee يعني لو عملت collection .. collection من ال employee بقدر يشير .. يشير لمين؟ يشير على full-time و يقدر يشير على ال part-time لأن عبارة عن العلاقة بينهم is", "tokens": [2407, 41185, 18871, 16254, 644, 12, 3766, 10738, 4032, 41185, 18871, 16254, 1577, 12, 3766, 10738, 12399, 3714, 19913, 3555, 2407, 9566, 22807, 11933, 1829, 8592, 18863, 15040, 28671, 49374, 16095, 22807, 2423, 644, 12, 3766, 10738, 307, 257, 10738, 4032, 2423, 1577, 12, 3766, 307, 364, 10738, 37495, 22653, 45164, 6225, 42213, 2655, 5765, 4386, 5765, 9154, 2423, 10738, 4724, 28543, 2288, 7251, 8592, 13546, 4386, 7251, 8592, 13546, 32767, 9957, 22807, 7251, 8592, 13546, 15844, 1577, 12, 3766, 4032, 7251, 28543, 2288, 7251, 8592, 13546, 15844, 2423, 644, 12, 3766, 5296, 33456, 6225, 3555, 9640, 3660, 18871, 18863, 15040, 28671, 49374, 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يقدر", "probability": 0.9191080729166666}, {"start": 121.44, "end": 121.7, "word": " يشير", "probability": 0.99072265625}, {"start": 121.7, "end": 121.94, "word": " على", "probability": 0.93359375}, {"start": 121.94, "end": 122.14, "word": " ال", "probability": 0.98974609375}, {"start": 122.14, "end": 122.36, "word": " part", "probability": 0.9638671875}, {"start": 122.36, "end": 122.56, "word": "-time", "probability": 0.98583984375}, {"start": 122.56, "end": 122.78, "word": " لأن", "probability": 0.85986328125}, {"start": 122.78, "end": 123.06, "word": " عبارة", "probability": 0.871337890625}, {"start": 123.06, "end": 123.12, "word": " عن", "probability": 0.662109375}, {"start": 123.12, "end": 123.38, "word": " العلاقة", "probability": 0.8767903645833334}, {"start": 123.38, "end": 123.72, "word": " بينهم", "probability": 0.988037109375}, {"start": 123.72, "end": 124.06, "word": " is", "probability": 0.92431640625}], "temperature": 1.0}, {"id": 5, "seek": 15461, "start": 125.63, "end": 154.61, "text": "data structure إيش يعني generate data structure؟ إنها مش مرتبطة بنوع معين من البيانات مش مرتبطة بنوع معين من البيانات وبالتالي بقدر ال list هذه تحتوي أي نوع من ال objects اللي ممكن يخطر على بالك طيب السؤال اللي بيطرح نفسه لو أنا بدي array أو بدي collection of integers شو بدي أسوي؟ الآن أنا بدي على سبيل المثال بدي list", "tokens": [67, 3274, 3877, 11933, 1829, 8592, 37495, 22653, 8460, 1412, 3877, 22807, 36145, 11296, 37893, 3714, 43500, 3555, 9566, 3660, 44945, 45367, 20449, 9957, 9154, 2423, 21292, 7649, 9307, 37893, 3714, 43500, 3555, 9566, 3660, 44945, 45367, 20449, 9957, 9154, 2423, 21292, 7649, 9307, 46599, 6027, 2655, 6027, 1829, 4724, 28543, 2288, 2423, 1329, 29538, 6055, 33753, 45865, 36632, 8717, 45367, 9154, 2423, 6565, 13672, 1829, 3714, 43020, 7251, 9778, 9566, 2288, 15844, 20666, 4117, 23032, 1829, 3555, 21136, 33604, 6027, 13672, 1829, 4724, 1829, 9566, 2288, 5016, 8717, 36178, 3224, 45164, 41850, 4724, 16254, 10225, 34051, 4724, 16254, 5765, 295, 41674, 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{"start": 135.01, "end": 135.77, "word": " بقدر", "probability": 0.9344075520833334}, {"start": 135.77, "end": 136.47, "word": " ال", "probability": 0.67529296875}, {"start": 136.47, "end": 136.85, "word": " list", "probability": 0.95263671875}, {"start": 136.85, "end": 137.27, "word": " هذه", "probability": 0.75048828125}, {"start": 137.27, "end": 138.17, "word": " تحتوي", "probability": 0.9791666666666666}, {"start": 138.17, "end": 138.55, "word": " أي", "probability": 0.89453125}, {"start": 138.55, "end": 139.03, "word": " نوع", "probability": 0.998291015625}, {"start": 139.03, "end": 139.91, "word": " من", "probability": 0.99267578125}, {"start": 139.91, "end": 140.03, "word": " ال", "probability": 0.9775390625}, {"start": 140.03, "end": 140.35, "word": " objects", "probability": 0.970703125}, {"start": 140.35, "end": 140.53, "word": " اللي", "probability": 0.975341796875}, {"start": 140.53, "end": 140.71, "word": " ممكن", "probability": 0.8564453125}, {"start": 140.71, "end": 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254.47, "end": 273.13, "text": "غير، يعني أنا الآن ممكن أstudy ال collections و أstudy كل ال static method اللي في داخلها لكن ماقدرش أستفيد من ال collection اللي جاريه من خلال ال implementation طيب ال interface collection لأن هو الأساس عامل implementation لمجموعة من ال method اللي لها علاقة بعض بالاش", "tokens": [17082, 13546, 12399, 37495, 22653, 41850, 6024, 48506, 3714, 43020, 5551, 28349, 88, 2423, 16641, 4032, 5551, 28349, 88, 28242, 2423, 13437, 3170, 13672, 1829, 8978, 11778, 47283, 1211, 11296, 44381, 19446, 28543, 2288, 8592, 5551, 14851, 5172, 25708, 9154, 2423, 5765, 13672, 1829, 10874, 9640, 1829, 3224, 9154, 16490, 1211, 6027, 2423, 11420, 23032, 1829, 3555, 2423, 9226, 5765, 5296, 33456, 31439, 16247, 3794, 32277, 6225, 10943, 1211, 11420, 32767, 7435, 2304, 2407, 27884, 9154, 2423, 3170, 13672, 1829, 5296, 11296, 11203, 995, 28671, 45030, 11242, 20666, 33599], "avg_logprob": -0.28715279036098057, "compression_ratio": 1.7444933920704846, "no_speech_prob": 0.0, "words": 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بين عناصر ال collection اللي موجودة يعني أنا بتكلم على group of objects اول حاجة ال collection can be converted to array والعكس صحيح مرت عليك شغل اسمها arrays class dot في عندنا شغل اسمها as list", "tokens": [3555, 6027, 28814, 11242, 31845, 3660, 16070, 2304, 3794, 5016, 16070, 2304, 4587, 9640, 1863, 3660, 19446, 49374, 18871, 33546, 2288, 2423, 5765, 13672, 1829, 3714, 29245, 23328, 3660, 37495, 22653, 41850, 39894, 4117, 19528, 15844, 1594, 295, 6565, 1975, 12610, 11331, 26108, 3660, 2423, 5765, 393, 312, 16424, 281, 10225, 16070, 3615, 4117, 3794, 20328, 5016, 1829, 5016, 3714, 43500, 25894, 4117, 13412, 17082, 1211, 24525, 2304, 11296, 41011, 1508, 5893, 8978, 43242, 8315, 13412, 17082, 1211, 24525, 2304, 11296, 382, 1329], "avg_logprob": -0.15048363627422423, "compression_ratio": 1.5416666666666667, "no_speech_prob": 0.0, "words": [{"start": 273.91, "end": 274.81, "word": "بالإضافة", "probability": 0.90087890625}, {"start": 274.81, "end": 275.97, "word": " والمسح", 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ال scanner object dot has", "tokens": [6027, 39184, 5751, 2868, 30981, 4724, 1829, 11622, 23328, 22653, 4724, 39184, 286, 391, 1639, 4724, 1829, 11622, 23328, 22653, 4724, 39184, 286, 391, 1639, 11933, 1829, 8592, 2423, 39184, 286, 391, 1639, 22807, 12174, 12610, 8315, 31439, 6225, 3555, 9640, 3660, 18871, 3861, 34051, 5682, 4724, 32640, 19452, 22653, 14739, 1829, 5551, 29973, 15844, 18871, 33546, 2288, 2423, 39184, 1329, 34051, 2423, 5765, 13672, 1829, 3714, 29245, 23328, 4032, 8592, 38688, 8315, 4032, 9957, 22807, 20449, 2423, 30211, 32767, 8592, 12174, 12610, 8315, 9122, 8315, 12174, 12610, 3224, 1339, 2423, 30211, 2657, 5893, 575], "avg_logprob": -0.23844401507327953, "compression_ratio": 1.7201834862385321, "no_speech_prob": 0.0, "words": [{"start": 327.93, "end": 328.25, "word": "الـ", "probability": 0.757080078125}, {"start": 328.25, "end": 328.73, "word": " Interface", "probability": 0.57940673828125}, {"start": 328.73, "end": 329.85, "word": " Collection", "probability": 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{"start": 349.57, "end": 349.85, "word": " قوله", "probability": 0.544189453125}, {"start": 349.85, "end": 350.39, "word": " while", "probability": 0.7392578125}, {"start": 350.39, "end": 352.31, "word": " ال", "probability": 0.85400390625}, {"start": 352.31, "end": 352.81, "word": " scanner", "probability": 0.90771484375}, {"start": 352.81, "end": 353.79, "word": " object", "probability": 0.95458984375}, {"start": 353.79, "end": 354.23, "word": " dot", "probability": 0.74853515625}, {"start": 354.23, "end": 355.67, "word": " has", "probability": 0.91943359375}], "temperature": 1.0}, {"id": 14, "seek": 38343, "start": 357.21, "end": 383.43, "text": "next أو has next line الآن هذا بنسميه iterator ايش ال iterator؟ هو عبارة عن object بمور على كل عناصر ال collection على كل عناصر ال collection ودر بالك هذه من أهم الميزات اللي بتفرج بين ال scanner و ال buffered reader", "tokens": [716, 734, 34051, 575, 958, 1622, 6024, 48506, 23758, 44945, 38251, 1829, 3224, 17138, 1639, 1975, 1829, 8592, 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{"start": 378.17, "end": 378.53, "word": " أهم", "probability": 0.829833984375}, {"start": 378.53, "end": 379.27, "word": " الميزات", "probability": 0.9625244140625}, {"start": 379.27, "end": 379.41, "word": " اللي", "probability": 0.896484375}, {"start": 379.41, "end": 379.87, "word": " بتفرج", "probability": 0.8038736979166666}, {"start": 379.87, "end": 380.21, "word": " بين", "probability": 0.97216796875}, {"start": 380.21, "end": 380.59, "word": " ال", "probability": 0.904296875}, {"start": 380.59, "end": 380.91, "word": " scanner", "probability": 0.912109375}, {"start": 380.91, "end": 381.91, "word": " و", "probability": 0.50439453125}, {"start": 381.91, "end": 382.01, "word": " ال", "probability": 0.82275390625}, {"start": 382.01, "end": 382.45, "word": " buffered", "probability": 0.77490234375}, {"start": 382.45, "end": 383.43, "word": " reader", "probability": 0.97705078125}], "temperature": 1.0}, {"id": 15, "seek": 41427, "start": 385.61, "end": 414.27, "text": "وبالتالي وجود الـ iterator عشان انا أستفيد منه ماهو الـ iterator؟ هو عبارة عن object بيخلّي البرنامج يمر عبر عناصر الـ collection كلها element إلى element وبقدر من خلاله أعمل remove لل element يعني انت تخيلي ان في عندي list عليها مجموعة من الألوان R أو Red أو Green", "tokens": [37746, 6027, 2655, 6027, 1829, 49610, 23328, 2423, 39184, 17138, 1639, 6225, 8592, 7649, 1975, 8315, 5551, 14851, 5172, 25708, 9154, 3224, 19446, 3224, 2407, 2423, 39184, 17138, 1639, 22807, 31439, 6225, 3555, 9640, 3660, 18871, 2657, 4724, 1829, 9778, 1211, 11703, 1829, 2423, 26890, 8315, 2304, 7435, 7251, 29973, 6225, 26890, 18871, 33546, 2288, 2423, 39184, 5765, 28242, 11296, 4478, 30731, 4478, 46599, 28543, 2288, 9154, 16490, 1211, 6027, 3224, 5551, 25957, 1211, 4159, 24976, 4478, 37495, 22653, 16472, 2655, 6055, 9778, 26895, 1829, 16472, 8978, 43242, 1829, 1329, 25894, 11296, 3714, 7435, 2304, 2407, 27884, 9154, 16247, 1211, 2407, 7649, 497, 34051, 4477, 34051, 6969], "avg_logprob": -0.25491896989168944, "compression_ratio": 1.6334661354581674, "no_speech_prob": 0.0, "words": [{"start": 385.61, "end": 386.13, "word": "وبالتالي", "probability": 0.96044921875}, {"start": 386.13, "end": 386.47, "word": " وجود", "probability": 0.953369140625}, {"start": 386.47, "end": 386.61, "word": " الـ", "probability": 0.917236328125}, {"start": 386.61, "end": 387.15, "word": " iterator", "probability": 0.716796875}, {"start": 387.15, "end": 387.81, "word": " عشان", "probability": 0.92626953125}, {"start": 387.81, "end": 387.97, "word": " انا", "probability": 0.69482421875}, {"start": 387.97, "end": 388.75, "word": " أستفيد", "probability": 0.76849365234375}, {"start": 388.75, "end": 389.01, "word": " منه", "probability": 0.982666015625}, {"start": 389.01, "end": 389.55, "word": " ماهو", "probability": 0.5796712239583334}, {"start": 389.55, "end": 389.69, "word": " الـ", "probability": 0.776611328125}, {"start": 389.69, "end": 390.59, "word": " iterator؟", "probability": 0.6766357421875}, {"start": 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"word": " تخيلي", "probability": 0.8543701171875}, {"start": 407.35, "end": 407.65, "word": " ان", "probability": 0.55029296875}, {"start": 407.65, "end": 407.95, "word": " في", "probability": 0.46044921875}, {"start": 407.95, "end": 408.31, "word": " عندي", "probability": 0.385498046875}, {"start": 408.31, "end": 408.63, "word": " list", "probability": 0.86279296875}, {"start": 408.63, "end": 409.47, "word": " عليها", "probability": 0.894287109375}, {"start": 409.47, "end": 409.85, "word": " مجموعة", "probability": 0.941796875}, {"start": 409.85, "end": 409.99, "word": " من", "probability": 0.91650390625}, {"start": 409.99, "end": 410.85, "word": " الألوان", "probability": 0.9808349609375}, {"start": 410.85, "end": 411.39, "word": " R", "probability": 0.69189453125}, {"start": 411.39, "end": 412.37, "word": " أو", "probability": 0.919921875}, {"start": 412.37, "end": 412.71, "word": " Red", "probability": 0.673828125}, {"start": 412.71, "end": 414.03, "word": " أو", "probability": 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"start": 473.85, "end": 492.41, "text": "النغل اللي في الآخر مافيش element معناته هتكون ال method has next ال iterator dot has next بترجع ب false طيب ال current position اللي أنا بقشر عليه بإمكاني زي ما بقرأه بال next ممكن أروح أقوله ال iterator dot", "tokens": [6027, 1863, 17082, 1211, 13672, 1829, 8978, 6024, 95, 34740, 19446, 41185, 8592, 4478, 20449, 8315, 47395, 8032, 2655, 30544, 2423, 3170, 575, 958, 2423, 17138, 1639, 5893, 575, 958, 39894, 47341, 3615, 4724, 7908, 23032, 1829, 3555, 2423, 2190, 2535, 13672, 1829, 41850, 4724, 4587, 8592, 2288, 47356, 4724, 28814, 2304, 41361, 1829, 30767, 1829, 19446, 4724, 4587, 2288, 10721, 3224, 20666, 958, 3714, 43020, 5551, 32887, 5016, 5551, 39648, 3224, 2423, 17138, 1639, 5893], "avg_logprob": -0.19287744203171173, "compression_ratio": 1.5431472081218274, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 473.85, "end": 474.31, "word": "النغل", "probability": 0.71551513671875}, {"start": 474.31, "end": 474.41, "word": " اللي", 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"word": " بقشر", "probability": 0.7303466796875}, {"start": 487.27, "end": 487.61, "word": " عليه", "probability": 0.9873046875}, {"start": 487.61, "end": 488.75, "word": " بإمكاني", "probability": 0.96142578125}, {"start": 488.75, "end": 488.97, "word": " زي", "probability": 0.96728515625}, {"start": 488.97, "end": 489.05, "word": " ما", "probability": 0.9775390625}, {"start": 489.05, "end": 489.63, "word": " بقرأه", "probability": 0.817138671875}, {"start": 489.63, "end": 489.79, "word": " بال", "probability": 0.98779296875}, {"start": 489.79, "end": 490.21, "word": " next", "probability": 0.9599609375}, {"start": 490.21, "end": 490.85, "word": " ممكن", "probability": 0.982421875}, {"start": 490.85, "end": 491.07, "word": " أروح", "probability": 0.8492838541666666}, {"start": 491.07, "end": 491.33, "word": " أقوله", "probability": 0.88037109375}, {"start": 491.33, "end": 491.43, "word": " ال", "probability": 0.947265625}, {"start": 491.43, "end": 491.99, "word": " iterator", 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"word": " يحذف", "probability": 0.9813232421875}, {"start": 496.59, "end": 496.71, "word": " ال", "probability": 0.83447265625}, {"start": 496.71, "end": 496.97, "word": " element", "probability": 0.4580078125}, {"start": 496.97, "end": 497.25, "word": " هذا", "probability": 0.40283203125}, {"start": 497.25, "end": 497.53, "word": " من", "probability": 0.982421875}, {"start": 497.53, "end": 498.37, "word": " ال", "probability": 0.85400390625}, {"start": 498.37, "end": 498.77, "word": " collection", "probability": 0.869140625}, {"start": 498.77, "end": 499.37, "word": " عشان", "probability": 0.9661458333333334}, {"start": 499.37, "end": 499.49, "word": " هيك", "probability": 0.8681640625}, {"start": 499.49, "end": 499.81, "word": " بقول", "probability": 0.941162109375}, {"start": 499.81, "end": 500.29, "word": " انه", "probability": 0.590087890625}, {"start": 500.29, "end": 500.59, "word": " بقدر", "probability": 0.943359375}, {"start": 500.59, "end": 500.81, "word": " يمر", 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149483, "start": 1472.27, "end": 1494.83, "text": "string s في مين؟ أو الـ C في ال killers صح؟ ماشي راح أقوله ال dot add ال C أو ال S مش قضية كتير وبالتالي يعني اللوب هذا يقدر يعملها implementation بال 4H contains قلنا بترجع ب true", "tokens": [37045, 262, 8978, 3714, 9957, 22807, 34051, 2423, 39184, 383, 8978, 2423, 39369, 20328, 5016, 22807, 3714, 33599, 1829, 12602, 39319, 5551, 39648, 3224, 2423, 5893, 909, 2423, 383, 34051, 2423, 318, 37893, 12174, 11242, 10632, 9122, 2655, 13546, 46599, 6027, 2655, 6027, 1829, 37495, 22653, 13672, 37746, 23758, 7251, 28543, 2288, 7251, 25957, 1211, 11296, 11420, 20666, 1017, 39, 8306, 12174, 1211, 8315, 39894, 47341, 3615, 4724, 2074], "avg_logprob": -0.31406249489103044, "compression_ratio": 1.3826530612244898, "no_speech_prob": 0.0, "words": [{"start": 1472.27, "end": 1472.79, "word": "string", "probability": 0.8173828125}, {"start": 1472.79, "end": 1473.21, "word": " s", "probability": 0.5068359375}, {"start": 1473.21, "end": 1473.41, "word": 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1494.83, "word": " true", "probability": 0.9189453125}], "temperature": 1.0}, {"id": 56, "seek": 152502, "start": 1495.7, "end": 1525.02, "text": "لو كان ال color موجود او لو كان ال object موجود ال color list dot contains it true white هترجع ب false نفي ال false true يعني لو كان اللون مش موجود اضيفه لو انا بدى اطبع ال array او ال array list اللى عندى ممكن اطبعهم element element بناء على ال index و ال size تبعتها لحظة انا ماتكلمتش على ال iterator لحد اللحظة", "tokens": [1211, 2407, 25961, 2423, 2017, 3714, 29245, 23328, 1975, 2407, 45164, 25961, 2423, 2657, 3714, 29245, 23328, 2423, 2017, 1329, 5893, 8306, 309, 2074, 2418, 8032, 2655, 47341, 3615, 4724, 7908, 8717, 41185, 2423, 7908, 2074, 37495, 22653, 45164, 25961, 13672, 11536, 37893, 3714, 29245, 23328, 1975, 11242, 33911, 3224, 45164, 1975, 8315, 47525, 7578, 1975, 9566, 3555, 3615, 2423, 10225, 1975, 2407, 2423, 10225, 1329, 13672, 7578, 43242, 7578, 3714, 43020, 1975, 9566, 3555, 3615, 16095, 4478, 4478, 44945, 16606, 15844, 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"word": " ال", "probability": 0.95947265625}, {"start": 1497.5, "end": 1497.76, "word": " object", "probability": 0.97265625}, {"start": 1497.76, "end": 1498.28, "word": " موجود", "probability": 0.9886067708333334}, {"start": 1498.28, "end": 1498.94, "word": " ال", "probability": 0.7744140625}, {"start": 1498.94, "end": 1499.2, "word": " color", "probability": 0.80126953125}, {"start": 1499.2, "end": 1499.56, "word": " list", "probability": 0.71484375}, {"start": 1499.56, "end": 1499.8, "word": " dot", "probability": 0.568359375}, {"start": 1499.8, "end": 1500.24, "word": " contains", "probability": 0.59814453125}, {"start": 1500.24, "end": 1500.5, "word": " it", "probability": 0.414794921875}, {"start": 1500.5, "end": 1500.76, "word": " true", "probability": 0.693359375}, {"start": 1500.76, "end": 1501.3, "word": " white", "probability": 0.65869140625}, {"start": 1501.3, "end": 1502.0, "word": " هترجع", "probability": 0.86279296875}, {"start": 1502.0, "end": 1502.12, "word": " ب", 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{"start": 1517.46, "end": 1518.84, "word": " ممكن", "probability": 0.98095703125}, {"start": 1518.84, "end": 1519.22, "word": " اطبعهم", "probability": 0.9357421875}, {"start": 1519.22, "end": 1519.56, "word": " element", "probability": 0.94287109375}, {"start": 1519.56, "end": 1519.88, "word": " element", "probability": 0.4775390625}, {"start": 1519.88, "end": 1520.16, "word": " بناء", "probability": 0.96435546875}, {"start": 1520.16, "end": 1520.36, "word": " على", "probability": 0.771484375}, {"start": 1520.36, "end": 1520.5, "word": " ال", "probability": 0.984375}, {"start": 1520.5, "end": 1520.94, "word": " index", "probability": 0.95458984375}, {"start": 1520.94, "end": 1522.02, "word": " و", "probability": 0.52783203125}, {"start": 1522.02, "end": 1522.16, "word": " ال", "probability": 0.90185546875}, {"start": 1522.16, "end": 1522.46, "word": " size", "probability": 0.9306640625}, {"start": 1522.46, "end": 1522.92, "word": " تبعتها", "probability": 0.79852294921875}, {"start": 1522.92, "end": 1523.22, "word": " لحظة", "probability": 0.9251708984375}, {"start": 1523.22, "end": 1523.32, "word": " انا", "probability": 0.765380859375}, {"start": 1523.32, "end": 1523.8, "word": " ماتكلمتش", "probability": 0.8812662760416666}, {"start": 1523.8, "end": 1523.9, "word": " على", "probability": 0.73095703125}, {"start": 1523.9, "end": 1524.0, "word": " ال", "probability": 0.96435546875}, {"start": 1524.0, "end": 1524.34, "word": " iterator", "probability": 0.90087890625}, {"start": 1524.34, "end": 1524.56, "word": " لحد", "probability": 0.537109375}, {"start": 1524.56, "end": 1525.02, "word": " اللحظة", "probability": 0.9761962890625}], "temperature": 1.0}, {"id": 57, "seek": 155029, "start": 1528.47, "end": 1550.29, "text": "ممكن اعتمد على ال 4H بداخل ال array list زي ما كتبته قبل شوية مع ال array اللى موجودة عندى مافيش مشكلة وممكن استفيد من ال iterator العرف iterator object على string iterator object على string يساوي color list dot iterator", "tokens": [2304, 43020, 1975, 34268, 2304, 3215, 15844, 2423, 1017, 39, 47525, 47283, 1211, 2423, 10225, 1329, 30767, 1829, 19446, 9122, 2655, 3555, 47395, 12174, 36150, 13412, 2407, 10632, 20449, 2423, 10225, 13672, 7578, 3714, 29245, 23328, 3660, 43242, 7578, 19446, 41185, 8592, 37893, 28820, 3660, 4032, 2304, 43020, 44713, 5172, 25708, 9154, 2423, 17138, 1639, 18863, 28480, 17138, 1639, 2657, 15844, 6798, 17138, 1639, 2657, 15844, 6798, 7251, 3794, 995, 45865, 2017, 1329, 5893, 17138, 1639], "avg_logprob": -0.24452109770341354, "compression_ratio": 1.6719576719576719, "no_speech_prob": 0.0, "words": [{"start": 1528.47, "end": 1528.81, "word": "ممكن", "probability": 0.81640625}, {"start": 1528.81, "end": 1529.23, "word": " اعتمد", "probability": 0.9345703125}, {"start": 1529.23, "end": 1529.45, "word": " على", "probability": 0.85546875}, {"start": 1529.45, "end": 1530.23, "word": " ال", "probability": 0.77978515625}, {"start": 1530.23, "end": 1530.89, "word": " 4H", "probability": 0.4705047607421875}, {"start": 1530.89, "end": 1531.73, "word": " بداخل", "probability": 0.7722981770833334}, {"start": 1531.73, "end": 1531.83, "word": " ال", "probability": 0.66015625}, {"start": 1531.83, "end": 1532.05, "word": " array", "probability": 0.56396484375}, {"start": 1532.05, "end": 1532.27, "word": " list", "probability": 0.884765625}, {"start": 1532.27, "end": 1532.45, "word": " زي", "probability": 0.73828125}, {"start": 1532.45, "end": 1532.51, "word": " ما", "probability": 0.7900390625}, {"start": 1532.51, "end": 1532.83, "word": " كتبته", "probability": 0.8072509765625}, {"start": 1532.83, "end": 1532.99, "word": " قبل", "probability": 0.96630859375}, {"start": 1532.99, "end": 1533.29, "word": " شوية", "probability": 0.8919270833333334}, {"start": 1533.29, "end": 1533.43, "word": " مع", "probability": 0.8388671875}, {"start": 1533.43, "end": 1533.53, "word": " ال", "probability": 0.8408203125}, {"start": 1533.53, "end": 1533.73, "word": " array", "probability": 0.89013671875}, {"start": 1533.73, "end": 1533.87, "word": " اللى", "probability": 0.6939697265625}, {"start": 1533.87, "end": 1534.17, "word": " موجودة", "probability": 0.9454345703125}, {"start": 1534.17, "end": 1534.55, "word": " عندى", "probability": 0.895263671875}, {"start": 1534.55, "end": 1535.17, "word": " مافيش", "probability": 0.8092447916666666}, {"start": 1535.17, "end": 1536.41, "word": " مشكلة", "probability": 0.98046875}, {"start": 1536.41, "end": 1537.23, "word": " وممكن", "probability": 0.7967122395833334}, {"start": 1537.23, "end": 1537.69, "word": " استفيد", "probability": 0.9303385416666666}, {"start": 1537.69, "end": 1537.93, "word": " من", "probability": 0.99560546875}, {"start": 1537.93, "end": 1539.07, "word": " ال", "probability": 0.9306640625}, {"start": 1539.07, "end": 1539.73, "word": " iterator", "probability": 0.8994140625}, {"start": 1539.73, "end": 1542.25, "word": " العرف", "probability": 0.574951171875}, {"start": 1542.25, "end": 1542.75, "word": " iterator", "probability": 0.822021484375}, {"start": 1542.75, "end": 1543.25, "word": " object", "probability": 0.9873046875}, {"start": 1543.25, "end": 1543.91, "word": " على", "probability": 0.74853515625}, {"start": 1543.91, "end": 1544.41, "word": " string", "probability": 0.89599609375}, {"start": 1544.41, "end": 1545.15, "word": " iterator", "probability": 0.64599609375}, {"start": 1545.15, "end": 1545.45, "word": " object", "probability": 0.97998046875}, {"start": 1545.45, "end": 1545.71, "word": " على", "probability": 0.900390625}, {"start": 1545.71, "end": 1546.19, "word": " string", "probability": 0.9326171875}, {"start": 1546.19, "end": 1547.57, "word": " يساوي", "probability": 0.79638671875}, {"start": 1547.57, "end": 1547.95, "word": " color", "probability": 0.433837890625}, {"start": 1547.95, "end": 1548.33, "word": " list", "probability": 0.583984375}, {"start": 1548.33, "end": 1548.87, "word": " dot", "probability": 0.685546875}, {"start": 1548.87, "end": 1550.29, "word": " iterator", "probability": 0.931884765625}], "temperature": 1.0}, {"id": 58, "seek": 157806, "start": 1551.44, "end": 1578.06, "text": "while الـ iterator dot has next مابهمنيش العدد جديش ولان مافيه element بدياهو مانعيش كلهم system dot out dot print line literator dot next عشان احصل على القيمة الموجودة بالمناسبة لو احنا عملنا system dot out dot print line او dot print ل ال colors فوق ايش ال output؟ هاي ال colors", "tokens": [7723, 2423, 39184, 17138, 1639, 5893, 575, 958, 3714, 16758, 16095, 22653, 8592, 18863, 3215, 3215, 10874, 16254, 8592, 35525, 7649, 19446, 41185, 3224, 4478, 4724, 16254, 40294, 2407, 3714, 7649, 3615, 1829, 8592, 28242, 16095, 1185, 5893, 484, 5893, 4482, 1622, 2733, 1639, 5893, 958, 6225, 8592, 7649, 1975, 5016, 36520, 15844, 25062, 32640, 3660, 9673, 29245, 23328, 3660, 20666, 2304, 8315, 35457, 3660, 45164, 1975, 5016, 8315, 6225, 42213, 8315, 1185, 5893, 484, 5893, 4482, 1622, 1975, 2407, 5893, 4482, 5296, 2423, 4577, 6156, 30543, 1975, 1829, 8592, 2423, 5598, 22807, 8032, 47302, 2423, 4577], "avg_logprob": -0.2651466709010455, "compression_ratio": 1.7443946188340806, "no_speech_prob": 0.0, "words": [{"start": 1551.44, "end": 1551.88, "word": "while", "probability": 0.703125}, {"start": 1551.88, "end": 1552.02, "word": " الـ", "probability": 0.3525390625}, {"start": 1552.02, "end": 1552.42, "word": " iterator", "probability": 0.77490234375}, {"start": 1552.42, "end": 1552.62, "word": " dot", "probability": 0.51171875}, {"start": 1552.62, "end": 1553.18, "word": " has", "probability": 0.9091796875}, {"start": 1553.18, "end": 1554.1, "word": " next", "probability": 0.460693359375}, {"start": 1554.1, "end": 1555.28, "word": " مابهمنيش", "probability": 0.7401611328125}, {"start": 1555.28, "end": 1555.58, "word": " العدد", "probability": 0.9484049479166666}, {"start": 1555.58, "end": 1556.04, "word": " جديش", "probability": 0.7757161458333334}, {"start": 1556.04, "end": 1556.32, "word": " ولان", "probability": 0.22674560546875}, {"start": 1556.32, "end": 1556.62, "word": " مافيه", "probability": 0.8621419270833334}, {"start": 1556.62, "end": 1557.06, "word": " element", "probability": 0.9443359375}, {"start": 1557.06, "end": 1557.68, "word": " بدياهو", "probability": 0.54052734375}, {"start": 1557.68, "end": 1558.12, "word": " مانعيش", "probability": 0.773046875}, {"start": 1558.12, "end": 1558.74, "word": " كلهم", "probability": 0.959716796875}, {"start": 1558.74, "end": 1559.92, "word": " system", "probability": 0.7646484375}, {"start": 1559.92, "end": 1560.16, "word": " dot", "probability": 0.92431640625}, {"start": 1560.16, "end": 1560.48, "word": " out", "probability": 0.88525390625}, {"start": 1560.48, "end": 1560.66, "word": " dot", "probability": 0.79833984375}, {"start": 1560.66, "end": 1560.92, "word": " print", "probability": 0.85986328125}, {"start": 1560.92, "end": 1561.32, "word": " line", "probability": 0.8916015625}, {"start": 1561.32, "end": 1562.3, "word": " literator", "probability": 0.376708984375}, {"start": 1562.3, "end": 1562.62, "word": " dot", "probability": 0.97900390625}, {"start": 1562.62, "end": 1563.1, "word": " next", "probability": 0.978515625}, {"start": 1563.1, "end": 1563.52, "word": " عشان", "probability": 0.9806315104166666}, {"start": 1563.52, "end": 1563.84, "word": " احصل", "probability": 0.8097330729166666}, {"start": 1563.84, "end": 1563.94, "word": " على", "probability": 0.69287109375}, {"start": 1563.94, "end": 1564.24, "word": " القيمة", "probability": 0.9676106770833334}, {"start": 1564.24, "end": 1564.66, "word": " الموجودة", "probability": 0.9677734375}, {"start": 1564.66, "end": 1565.94, "word": " بالمناسبة", "probability": 0.97255859375}, {"start": 1565.94, "end": 1566.16, "word": " لو", "probability": 0.859375}, {"start": 1566.16, "end": 1566.38, "word": " احنا", "probability": 0.9376627604166666}, {"start": 1566.38, "end": 1566.7, "word": " عملنا", "probability": 0.98193359375}, {"start": 1566.7, "end": 1567.1, "word": " system", "probability": 0.96923828125}, {"start": 1567.1, "end": 1567.44, "word": " dot", "probability": 0.974609375}, {"start": 1567.44, "end": 1567.8, "word": " out", "probability": 0.91845703125}, {"start": 1567.8, "end": 1568.04, "word": " dot", "probability": 0.9755859375}, {"start": 1568.04, "end": 1568.34, "word": " print", "probability": 0.96630859375}, {"start": 1568.34, "end": 1568.76, "word": " line", "probability": 0.9765625}, {"start": 1568.76, "end": 1569.76, "word": " او", "probability": 0.7042236328125}, {"start": 1569.76, "end": 1569.9, "word": " dot", "probability": 0.95654296875}, {"start": 1569.9, "end": 1570.4, "word": " print", "probability": 0.9755859375}, {"start": 1570.4, "end": 1571.44, "word": " ل", "probability": 0.64306640625}, {"start": 1571.44, "end": 1572.28, "word": " ال", "probability": 0.66015625}, {"start": 1572.28, "end": 1572.7, "word": " colors", "probability": 0.626953125}, {"start": 1572.7, "end": 1573.32, "word": " فوق", "probability": 0.77001953125}, {"start": 1573.32, "end": 1574.08, "word": " ايش", "probability": 0.76806640625}, {"start": 1574.08, "end": 1574.2, "word": " ال", "probability": 0.98095703125}, {"start": 1574.2, "end": 1575.94, "word": " output؟", "probability": 0.8349609375}, {"start": 1575.94, "end": 1577.74, "word": " هاي", "probability": 0.652587890625}, {"start": 1577.74, "end": 1577.84, "word": " ال", "probability": 0.9921875}, {"start": 1577.84, "end": 1578.06, "word": " colors", "probability": 0.87255859375}], "temperature": 1.0}, {"id": 59, "seek": 161120, "start": 1581.52, "end": 1611.2, "text": "أيوة بتديني ال reference address بتقولها طيب لو أنا راح قلتله print ال color list نفس الأشياء لأ هأضعلك الريب الشكل هذا red كما blue green احنا حطيناه في البداية", "tokens": [10721, 1829, 2407, 3660, 39894, 3215, 9957, 1829, 2423, 6408, 2985, 39894, 39648, 11296, 23032, 1829, 3555, 45164, 41850, 12602, 39319, 12174, 1211, 2655, 43761, 4482, 2423, 2017, 1329, 8717, 36178, 16247, 8592, 1829, 16606, 5296, 10721, 8032, 10721, 11242, 3615, 23275, 34892, 1829, 3555, 25124, 28820, 23758, 2182, 9122, 15042, 3344, 3092, 1975, 5016, 8315, 11331, 9566, 1829, 8315, 3224, 8978, 29739, 28259, 10632], "avg_logprob": -0.37263258840098523, "compression_ratio": 1.4022346368715084, "no_speech_prob": 0.0, "words": [{"start": 1581.52, "end": 1582.04, "word": "أيوة", "probability": 0.76385498046875}, {"start": 1582.04, "end": 1583.08, "word": " بتديني", "probability": 0.715545654296875}, {"start": 1583.08, "end": 1583.14, "word": " ال", "probability": 0.76611328125}, {"start": 1583.14, "end": 1583.48, "word": " reference", "probability": 0.80859375}, {"start": 1583.48, "end": 1584.44, "word": " address", "probability": 0.6923828125}, {"start": 1584.44, "end": 1584.96, "word": " بتقولها", "probability": 0.4782307942708333}, {"start": 1584.96, "end": 1585.86, "word": " طيب", "probability": 0.7672526041666666}, {"start": 1585.86, "end": 1586.28, "word": " لو", "probability": 0.8828125}, {"start": 1586.28, "end": 1586.46, "word": " أنا", "probability": 0.57666015625}, {"start": 1586.46, "end": 1586.58, "word": " راح", "probability": 0.70849609375}, {"start": 1586.58, "end": 1587.14, "word": " قلتله", "probability": 0.8668212890625}, {"start": 1587.14, "end": 1587.9, "word": " print", "probability": 0.253662109375}, {"start": 1587.9, "end": 1590.36, "word": " ال", "probability": 0.84716796875}, {"start": 1590.36, "end": 1590.64, "word": " color", "probability": 0.67041015625}, {"start": 1590.64, "end": 1591.54, "word": " list", "probability": 0.90966796875}, {"start": 1591.54, "end": 1597.98, "word": " نفس", "probability": 0.982666015625}, {"start": 1597.98, "end": 1598.42, "word": " الأشياء", "probability": 0.9105224609375}, {"start": 1598.42, "end": 1599.14, "word": " لأ", "probability": 0.796142578125}, {"start": 1599.14, "end": 1601.36, "word": " هأضعلك", "probability": 0.5934326171875}, {"start": 1601.36, "end": 1602.26, "word": " الريب", "probability": 0.5907389322916666}, {"start": 1602.26, "end": 1602.62, "word": " الشكل", "probability": 0.963134765625}, {"start": 1602.62, "end": 1603.04, "word": " هذا", "probability": 0.92529296875}, {"start": 1603.04, "end": 1605.02, "word": " red", "probability": 0.5703125}, {"start": 1605.02, "end": 1606.94, "word": " كما", "probability": 0.544921875}, {"start": 1606.94, "end": 1607.86, "word": " blue", "probability": 0.90478515625}, {"start": 1607.86, "end": 1609.8, "word": " green", "probability": 0.378662109375}, {"start": 1609.8, "end": 1610.0, "word": " احنا", "probability": 0.8017578125}, {"start": 1610.0, "end": 1610.62, "word": " حطيناه", "probability": 0.777001953125}, {"start": 1610.62, "end": 1610.74, "word": " في", "probability": 0.88525390625}, {"start": 1610.74, "end": 1611.2, "word": " البداية", "probability": 0.9890950520833334}], "temperature": 1.0}, {"id": 60, "seek": 164208, "start": 1614.64, "end": 1642.08, "text": "green blue و white وهذا الفرق الأساسي بين ال array و ال list لأنه في مجال أن أشوف ال data اللي موجودة في الداخل ال list as one shot كأنها one element أنا بأتعامل معاه طيب في طريقة تانية اللي حكيناها قبل شوية", "tokens": [27399, 3344, 4032, 2418, 37037, 15730, 27188, 2288, 4587, 16247, 3794, 32277, 1829, 49374, 2423, 10225, 4032, 2423, 1329, 5296, 33456, 3224, 8978, 3714, 7435, 6027, 14739, 5551, 8592, 38688, 2423, 1412, 13672, 1829, 3714, 29245, 23328, 3660, 8978, 32748, 47283, 1211, 2423, 1329, 382, 472, 3347, 9122, 33456, 11296, 472, 4478, 41850, 4724, 10721, 2655, 3615, 10943, 1211, 20449, 40294, 23032, 1829, 3555, 8978, 23032, 16572, 28671, 6055, 7649, 10632, 13672, 1829, 11331, 4117, 1829, 8315, 11296, 12174, 36150, 13412, 2407, 10632], "avg_logprob": -0.22507439890787714, "compression_ratio": 1.5707317073170732, "no_speech_prob": 0.0, "words": [{"start": 1614.64, "end": 1615.48, "word": "green", "probability": 0.4267578125}, {"start": 1615.48, "end": 1616.32, "word": " blue", "probability": 0.53564453125}, {"start": 1616.32, "end": 1617.8, "word": " و", "probability": 0.4560546875}, {"start": 1617.8, "end": 1618.1, "word": " white", "probability": 0.4921875}, {"start": 1618.1, "end": 1619.26, "word": " وهذا", "probability": 0.891845703125}, {"start": 1619.26, "end": 1619.56, "word": " الفرق", "probability": 0.8642578125}, {"start": 1619.56, "end": 1620.02, "word": " الأساسي", "probability": 0.9285888671875}, {"start": 1620.02, "end": 1620.2, "word": " بين", "probability": 0.87890625}, {"start": 1620.2, "end": 1620.32, "word": " ال", "probability": 0.64892578125}, {"start": 1620.32, "end": 1620.58, "word": " array", "probability": 0.33203125}, {"start": 1620.58, "end": 1620.98, "word": " و", "probability": 0.7021484375}, {"start": 1620.98, "end": 1622.62, "word": " ال", "probability": 0.37158203125}, {"start": 1622.62, "end": 1623.06, "word": " list", "probability": 0.912109375}, {"start": 1623.06, "end": 1623.62, "word": " لأنه", "probability": 0.5211588541666666}, {"start": 1623.62, "end": 1623.7, "word": " في", "probability": 0.67529296875}, {"start": 1623.7, "end": 1624.16, "word": " مجال", "probability": 0.9894205729166666}, {"start": 1624.16, "end": 1624.28, "word": " أن", "probability": 0.55615234375}, {"start": 1624.28, "end": 1624.7, "word": " أشوف", "probability": 0.7281087239583334}, {"start": 1624.7, "end": 1624.88, "word": " ال", "probability": 0.90380859375}, {"start": 1624.88, "end": 1625.3, "word": " data", "probability": 0.9814453125}, {"start": 1625.3, "end": 1626.24, "word": " اللي", "probability": 0.790771484375}, {"start": 1626.24, "end": 1626.76, "word": " موجودة", "probability": 0.97998046875}, {"start": 1626.76, "end": 1626.88, "word": " في", "probability": 0.80615234375}, {"start": 1626.88, "end": 1627.42, "word": " الداخل", "probability": 0.8435872395833334}, {"start": 1627.42, "end": 1628.38, "word": " ال", "probability": 0.7529296875}, {"start": 1628.38, "end": 1628.66, "word": " list", "probability": 0.97216796875}, {"start": 1628.66, "end": 1628.94, "word": " as", "probability": 0.69873046875}, {"start": 1628.94, "end": 1629.12, "word": " one", "probability": 0.9423828125}, {"start": 1629.12, "end": 1629.48, "word": " shot", "probability": 0.8720703125}, {"start": 1629.48, "end": 1630.06, "word": " كأنها", "probability": 0.861328125}, {"start": 1630.06, "end": 1630.24, "word": " one", "probability": 0.89892578125}, {"start": 1630.24, "end": 1630.72, "word": " element", "probability": 0.97998046875}, {"start": 1630.72, "end": 1630.96, "word": " أنا", "probability": 0.4501953125}, {"start": 1630.96, "end": 1631.46, "word": " بأتعامل", "probability": 0.8368326822916666}, {"start": 1631.46, "end": 1632.54, "word": " معاه", "probability": 0.84326171875}, {"start": 1632.54, "end": 1635.56, "word": " طيب", "probability": 0.8795572916666666}, {"start": 1635.56, "end": 1640.22, "word": " في", "probability": 0.6923828125}, {"start": 1640.22, "end": 1640.6, "word": " طريقة", "probability": 0.9861653645833334}, {"start": 1640.6, "end": 1640.9, "word": " تانية", "probability": 0.9908854166666666}, {"start": 1640.9, "end": 1641.04, "word": " اللي", "probability": 0.940185546875}, {"start": 1641.04, "end": 1641.48, "word": " حكيناها", "probability": 0.8865234375}, {"start": 1641.48, "end": 1641.68, "word": " قبل", "probability": 0.953857421875}, {"start": 1641.68, "end": 1642.08, "word": " شوية", "probability": 0.908203125}], "temperature": 1.0}, {"id": 61, "seek": 167106, "start": 1643.0, "end": 1671.06, "text": "اللي هي arrays.asList الـ arrays class في method aesthetic method اسمها asList بترجع ب object من نوع list وبالتالي أنا بقدر أستفيد منه أستفيد من ال array .. من ال arrays.asList عشان أضيف ال element مرة واحدة بدل ما أضيفهم element element من خلال .. أولا هقول له ال list تبعتي بدأت ساوي arrays.asList colors صارت في عندي list", "tokens": [6027, 20292, 39896, 41011, 13, 296, 43, 468, 2423, 39184, 41011, 1508, 8978, 3170, 20092, 3170, 24525, 2304, 11296, 382, 43, 468, 39894, 47341, 3615, 4724, 2657, 9154, 8717, 45367, 1329, 46599, 6027, 2655, 6027, 1829, 41850, 4724, 28543, 2288, 5551, 14851, 5172, 25708, 9154, 3224, 5551, 14851, 5172, 25708, 9154, 2423, 10225, 4386, 9154, 2423, 41011, 13, 296, 43, 468, 6225, 8592, 7649, 5551, 11242, 33911, 2423, 4478, 3714, 25720, 36764, 24401, 3660, 47525, 1211, 19446, 5551, 11242, 33911, 16095, 4478, 4478, 9154, 16490, 1211, 6027, 4386, 5551, 12610, 995, 8032, 39648, 46740, 2423, 1329, 6055, 3555, 3615, 31371, 47525, 10721, 2655, 8608, 995, 45865, 41011, 13, 296, 43, 468, 4577, 20328, 9640, 2655, 8978, 18871, 16254, 1329], "avg_logprob": -0.2204427053531011, "compression_ratio": 1.751908396946565, "no_speech_prob": 0.0, "words": [{"start": 1643.0, "end": 1643.28, "word": "اللي", "probability": 0.810546875}, {"start": 1643.28, "end": 1643.46, "word": " هي", "probability": 0.90771484375}, {"start": 1643.46, "end": 1644.18, "word": " arrays", "probability": 0.319580078125}, {"start": 1644.18, "end": 1646.22, "word": ".asList", "probability": 0.73577880859375}, {"start": 1646.22, "end": 1647.34, "word": " الـ", "probability": 0.33599853515625}, {"start": 1647.34, "end": 1647.62, "word": " arrays", "probability": 0.55810546875}, {"start": 1647.62, "end": 1648.2, "word": " class", "probability": 0.9609375}, {"start": 1648.2, "end": 1649.12, "word": " في", "probability": 0.5634765625}, {"start": 1649.12, "end": 1649.44, "word": " method", "probability": 0.70654296875}, {"start": 1649.44, "end": 1649.76, "word": " aesthetic", "probability": 0.264892578125}, {"start": 1649.76, "end": 1650.1, "word": " method", "probability": 0.96875}, {"start": 1650.1, "end": 1650.62, "word": " اسمها", "probability": 0.96142578125}, {"start": 1650.62, "end": 1651.86, "word": " asList", "probability": 0.8098958333333334}, {"start": 1651.86, "end": 1652.44, "word": " بترجع", "probability": 0.9388020833333334}, {"start": 1652.44, "end": 1652.56, "word": " ب", "probability": 0.5625}, {"start": 1652.56, "end": 1652.86, "word": " object", "probability": 0.82568359375}, {"start": 1652.86, "end": 1653.06, "word": " من", "probability": 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"probability": 0.8974609375}, {"start": 1662.4, "end": 1662.76, "word": " أضيفهم", "probability": 0.93408203125}, {"start": 1662.76, "end": 1663.02, "word": " element", "probability": 0.9814453125}, {"start": 1663.02, "end": 1663.52, "word": " element", "probability": 0.529296875}, {"start": 1663.52, "end": 1664.36, "word": " من", "probability": 0.99169921875}, {"start": 1664.36, "end": 1664.6, "word": " خلال", "probability": 0.9931640625}, {"start": 1664.6, "end": 1664.68, "word": " ..", "probability": 0.6728515625}, {"start": 1664.68, "end": 1664.8, "word": " أولا", "probability": 0.6542561848958334}, {"start": 1664.8, "end": 1664.98, "word": " هقول", "probability": 0.595458984375}, {"start": 1664.98, "end": 1665.06, "word": " له", "probability": 0.324951171875}, {"start": 1665.06, "end": 1665.16, "word": " ال", "probability": 0.7177734375}, {"start": 1665.16, "end": 1665.34, "word": " list", "probability": 0.9501953125}, {"start": 1665.34, "end": 1665.82, "word": " تبعتي", "probability": 0.8807373046875}, {"start": 1665.82, "end": 1666.72, "word": " بدأت", "probability": 0.7067057291666666}, {"start": 1666.72, "end": 1666.98, "word": " ساوي", "probability": 0.8356119791666666}, {"start": 1666.98, "end": 1667.56, "word": " arrays", "probability": 0.8701171875}, {"start": 1667.56, "end": 1668.76, "word": ".asList", "probability": 0.9493408203125}, {"start": 1668.76, "end": 1669.82, "word": " colors", "probability": 0.468994140625}, {"start": 1669.82, "end": 1670.46, "word": " صارت", "probability": 0.9436848958333334}, {"start": 1670.46, "end": 1670.56, "word": " في", "probability": 0.92431640625}, {"start": 1670.56, "end": 1670.78, "word": " عندي", "probability": 0.86572265625}, {"start": 1670.78, "end": 1671.06, "word": " list", "probability": 0.94873046875}], "temperature": 1.0}, {"id": 62, "seek": 169950, "start": 1672.04, "end": 1699.5, "text": "و أروح أستخدم ال list هذه as argument لل constructor تبعت ال array list أو ممكن بشكل مباشر أجيب ال line هذا بدون ال semi colon طبعا و أجيبه مباشر أحطه مكان ال list اللي عندي هان و بصير مباشر أخد كل عناصر ال array بدون مضطر أكتب ال code", "tokens": [2407, 5551, 32887, 5016, 5551, 14851, 9778, 40448, 2423, 1329, 29538, 382, 6770, 24976, 47479, 6055, 3555, 34268, 2423, 10225, 1329, 34051, 3714, 43020, 4724, 8592, 28820, 3714, 3555, 33599, 2288, 5551, 7435, 1829, 3555, 2423, 1622, 23758, 47525, 11536, 2423, 12909, 8255, 23032, 3555, 3615, 995, 4032, 5551, 7435, 1829, 3555, 3224, 3714, 3555, 33599, 2288, 5551, 5016, 9566, 3224, 3714, 41361, 2423, 1329, 13672, 1829, 18871, 16254, 8032, 7649, 4032, 4724, 9381, 13546, 3714, 3555, 33599, 2288, 5551, 9778, 3215, 28242, 18871, 33546, 2288, 2423, 10225, 47525, 11536, 3714, 11242, 9566, 2288, 5551, 4117, 2655, 3555, 2423, 3089], "avg_logprob": -0.1686262317223124, "compression_ratio": 1.7028301886792452, "no_speech_prob": 0.0, "words": [{"start": 1672.04, "end": 1672.26, "word": "و", "probability": 0.75341796875}, {"start": 1672.26, "end": 1672.5, "word": " أروح", "probability": 0.5796305338541666}, {"start": 1672.5, "end": 1672.96, "word": " أستخدم", "probability": 0.9066162109375}, {"start": 1672.96, "end": 1673.1, "word": " ال", "probability": 0.75830078125}, {"start": 1673.1, "end": 1673.28, "word": " list", "probability": 0.79638671875}, {"start": 1673.28, "end": 1673.74, "word": " هذه", "probability": 0.72021484375}, {"start": 1673.74, "end": 1675.62, "word": " as", "probability": 0.61865234375}, {"start": 1675.62, "end": 1676.14, "word": " argument", "probability": 0.720703125}, {"start": 1676.14, "end": 1676.42, "word": " لل", "probability": 0.5576171875}, {"start": 1676.42, "end": 1677.4, "word": " constructor", "probability": 0.75927734375}, {"start": 1677.4, "end": 1677.9, "word": " تبعت", "probability": 0.744873046875}, {"start": 1677.9, "end": 1679.48, "word": " ال", "probability": 0.82373046875}, {"start": 1679.48, "end": 1679.72, "word": " array", "probability": 0.9423828125}, {"start": 1679.72, "end": 1680.12, "word": " list", "probability": 0.90380859375}, {"start": 1680.12, "end": 1680.76, "word": " أو", "probability": 0.81640625}, {"start": 1680.76, "end": 1681.1, "word": " ممكن", "probability": 0.972412109375}, {"start": 1681.1, "end": 1681.46, "word": " بشكل", "probability": 0.9918619791666666}, {"start": 1681.46, "end": 1682.04, "word": " مباشر", "probability": 0.9931640625}, {"start": 1682.04, "end": 1684.58, "word": " أجيب", "probability": 0.95458984375}, {"start": 1684.58, "end": 1684.7, "word": " ال", "probability": 0.970703125}, {"start": 1684.7, "end": 1684.92, "word": " line", "probability": 0.9609375}, {"start": 1684.92, "end": 1685.4, "word": " هذا", "probability": 0.716796875}, {"start": 1685.4, "end": 1688.72, "word": " بدون", "probability": 0.927734375}, {"start": 1688.72, "end": 1688.86, "word": " ال", "probability": 0.75244140625}, {"start": 1688.86, "end": 1689.0, "word": " semi", "probability": 0.457275390625}, {"start": 1689.0, "end": 1689.26, "word": " colon", 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0.98095703125}], "temperature": 1.0}, {"id": 63, "seek": 172067, "start": 1700.75, "end": 1720.67, "text": "الطويل السابق اللي احنا شوفناه قبل شوية هي فعليا arrays as list عملت عاملة implementation تماما لل code اللي احنا كتبناه قبل شوية عاملة iterator او عاملة loop على عناصر ال array واضفتهم بالترتيب السابق اللي احنا شوفناه", "tokens": [6027, 9566, 2407, 26895, 21136, 16758, 4587, 13672, 1829, 1975, 5016, 8315, 13412, 38688, 8315, 3224, 12174, 36150, 13412, 2407, 10632, 39896, 6156, 3615, 20292, 995, 41011, 382, 1329, 6225, 42213, 2655, 6225, 10943, 37977, 11420, 46811, 10943, 995, 24976, 3089, 13672, 1829, 1975, 5016, 8315, 9122, 2655, 3555, 8315, 3224, 12174, 36150, 13412, 2407, 10632, 6225, 10943, 37977, 17138, 1639, 1975, 2407, 6225, 10943, 37977, 6367, 15844, 18871, 33546, 2288, 2423, 10225, 4032, 46958, 5172, 2655, 16095, 20666, 2655, 2288, 31371, 3555, 21136, 16758, 4587, 13672, 1829, 1975, 5016, 8315, 13412, 38688, 8315, 3224], "avg_logprob": -0.1545410129862527, 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2233.74, "end": 2262.3, "text": "و رائد مثلا و أضفت هدول لست أضفت هدول لست بناء على hash function تمام تحدد ال position بناء على عدد ال characters بناء على عدد ال characters بهاء خمسة أحمد أو خالد ستة أحمد خمسة رائد أربعة يعني انه رائد في الأول", "tokens": [2407, 12602, 16373, 3215, 50113, 15040, 4032, 5551, 11242, 5172, 2655, 8032, 3215, 12610, 5296, 14851, 5551, 11242, 5172, 2655, 8032, 3215, 12610, 5296, 14851, 44945, 16606, 15844, 22019, 2445, 46811, 10943, 6055, 24401, 3215, 2423, 2535, 44945, 16606, 15844, 6225, 3215, 3215, 2423, 4342, 44945, 16606, 15844, 6225, 3215, 3215, 2423, 4342, 39627, 16606, 16490, 2304, 3794, 3660, 5551, 35571, 3215, 34051, 16490, 6027, 3215, 8608, 2655, 3660, 5551, 35571, 3215, 16490, 2304, 3794, 3660, 12602, 16373, 3215, 5551, 25513, 27884, 37495, 22653, 16472, 3224, 12602, 16373, 3215, 8978, 16247, 12610], "avg_logprob": -0.1590221703693431, "compression_ratio": 1.9318181818181819, "no_speech_prob": 0.0, "words": [{"start": 2233.74, "end": 2234.4, 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hash", "probability": 0.81298828125}, {"start": 2244.08, "end": 2244.76, "word": " function", "probability": 0.9072265625}, {"start": 2244.76, "end": 2246.12, "word": " تمام", "probability": 0.90673828125}, {"start": 2246.12, "end": 2247.62, "word": " تحدد", "probability": 0.818359375}, {"start": 2247.62, "end": 2247.78, "word": " ال", "probability": 0.818359375}, {"start": 2247.78, "end": 2248.16, "word": " position", "probability": 0.94873046875}, {"start": 2248.16, "end": 2248.56, "word": " بناء", "probability": 0.959716796875}, {"start": 2248.56, "end": 2248.8, "word": " على", "probability": 0.83544921875}, {"start": 2248.8, "end": 2249.1, "word": " عدد", "probability": 0.9912109375}, {"start": 2249.1, "end": 2249.24, "word": " ال", "probability": 0.83251953125}, {"start": 2249.24, "end": 2249.76, "word": " characters", "probability": 0.83740234375}, {"start": 2249.76, "end": 2251.42, "word": " بناء", "probability": 0.909912109375}, {"start": 2251.42, "end": 2251.62, "word": " 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{"start": 2270.78, "end": 2271.24, "word": " الأشياء", "probability": 0.8095703125}, {"start": 2271.24, "end": 2271.76, "word": " الأولوية", "probability": 0.9207763671875}, {"start": 2271.76, "end": 2271.9, "word": " اللي", "probability": 0.708740234375}, {"start": 2271.9, "end": 2272.2, "word": " ظهر", "probability": 0.7103271484375}, {"start": 2272.2, "end": 2272.32, "word": " في", "probability": 0.8515625}, {"start": 2272.32, "end": 2272.64, "word": " الأول", "probability": 0.975341796875}, {"start": 2272.64, "end": 2277.44, "word": " و", "probability": 0.389892578125}, {"start": 2277.44, "end": 2278.3, "word": " بعدين", "probability": 0.957275390625}, {"start": 2278.3, "end": 2279.84, "word": " بتجيبلي", "probability": 0.84091796875}, {"start": 2279.84, "end": 2280.24, "word": " خالد", "probability": 0.9716796875}, {"start": 2280.24, "end": 2281.12, "word": " هذا", "probability": 0.703125}, {"start": 2281.12, "end": 2281.38, "word": " بناء", "probability": 0.912109375}, {"start": 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12174, 1211, 2655, 5296, 4117, 4724, 16254, 2423, 39184, 1422, 34051, 2423, 39184, 6838, 992, 24976, 992, 13672, 1829, 3714, 29245, 23328, 23758, 44945, 16606, 15844, 2423, 413, 29538, 2423, 2445, 29538, 22342, 4724, 2304, 12984, 43761, 1378, 992, 9673, 7435, 2304, 45367, 13672, 1829, 39896, 1422, 992, 9673, 7435, 2304, 45367, 25062, 36150, 16070, 6838, 992, 9154, 2423, 413, 24976, 148, 95, 34740], "avg_logprob": -0.3691123257512632, "compression_ratio": 1.6331360946745561, "no_speech_prob": 0.0, "words": [{"start": 2667.04, "end": 2667.3, "word": "و", "probability": 0.4873046875}, {"start": 2667.3, "end": 2667.52, "word": " جيت", "probability": 0.428436279296875}, {"start": 2667.52, "end": 2667.62, "word": " و", "probability": 0.467041015625}, {"start": 2667.62, "end": 2667.78, "word": " قلت", "probability": 0.8704427083333334}, {"start": 2667.78, "end": 2667.98, "word": " لك", "probability": 0.725830078125}, {"start": 2667.98, "end": 2668.44, "word": " بدي", "probability": 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0.83544921875}, {"start": 2672.64, "end": 2672.86, "word": " على", "probability": 0.701171875}, {"start": 2672.86, "end": 2673.02, "word": " ال", "probability": 0.77783203125}, {"start": 2673.02, "end": 2673.22, "word": " D", "probability": 0.69775390625}, {"start": 2673.22, "end": 2674.66, "word": " هذه", "probability": 0.5771484375}, {"start": 2674.66, "end": 2675.16, "word": " ال", "probability": 0.8984375}, {"start": 2675.16, "end": 2675.46, "word": " function", "probability": 0.54833984375}, {"start": 2675.46, "end": 2675.74, "word": " هذه", "probability": 0.22412109375}, {"start": 2675.74, "end": 2676.38, "word": " ABC", "probability": 0.333251953125}, {"start": 2676.38, "end": 2678.4, "word": " بمثله", "probability": 0.78271484375}, {"start": 2678.4, "end": 2679.22, "word": " head", "probability": 0.79638671875}, {"start": 2679.22, "end": 2679.68, "word": " set", "probability": 0.93310546875}, {"start": 2679.68, "end": 2682.5, "word": " المجموع", "probability": 0.875244140625}, {"start": 2682.5, "end": 2682.66, "word": " اللي", "probability": 0.6890869140625}, {"start": 2682.66, "end": 2682.72, "word": " هي", "probability": 0.464111328125}, {"start": 2682.72, "end": 2683.0, "word": " sub", "probability": 0.364990234375}, {"start": 2683.0, "end": 2683.34, "word": " set", "probability": 0.75}, {"start": 2683.34, "end": 2684.14, "word": " المجموع", "probability": 0.82012939453125}, {"start": 2684.14, "end": 2684.5, "word": " القبل", "probability": 0.942626953125}, {"start": 2684.5, "end": 2685.14, "word": " وال", "probability": 0.669921875}, {"start": 2685.14, "end": 2685.52, "word": " tail", "probability": 0.8125}, {"start": 2685.52, "end": 2685.96, "word": " set", "probability": 0.97119140625}, {"start": 2685.96, "end": 2686.32, "word": " من", "probability": 0.97998046875}, {"start": 2686.32, "end": 2686.5, "word": " ال", "probability": 0.92333984375}, {"start": 2686.5, "end": 2686.86, "word": " D", "probability": 0.95263671875}, {"start": 2686.86, "end": 2687.86, "word": " للآخر", "probability": 0.8623046875}], "temperature": 1.0}, {"id": 100, "seek": 271297, "start": 2689.05, "end": 2712.97, "text": "بتحتوى الـ D طب و ال first و ال last ال first element و ال last element اللي موجودين على ال tree تعالى نشوف ال code هذا على السريع المحاضرة الجاية ان شاء الله تعالى لأن الوقت أدركنا بنبدأ من عند ال sets و بنتكلم على ال tree set ان شاء الله تبارك وتعالى تي اي سؤال يا بنات؟ بيبقى سهل ال tree set انا بحدد من وين و من كده بناء على ال character اللي بتحدي دي نعم الله تكل عافية", "tokens": [3555, 2655, 33753, 2407, 7578, 2423, 39184, 413, 23032, 3555, 4032, 2423, 700, 4032, 2423, 1036, 2423, 700, 4478, 4032, 2423, 1036, 4478, 13672, 1829, 3714, 29245, 23328, 9957, 15844, 2423, 4230, 37279, 6027, 7578, 8717, 8592, 38688, 2423, 3089, 23758, 15844, 21136, 16572, 3615, 9673, 5016, 46958, 25720, 25724, 995, 10632, 16472, 13412, 16606, 21984, 37279, 6027, 7578, 5296, 33456, 2423, 30543, 2655, 5551, 3215, 31747, 8315, 44945, 44510, 10721, 9154, 43242, 2423, 6352, 4032, 44945, 2655, 4117, 19528, 15844, 2423, 4230, 992, 16472, 13412, 16606, 21984, 6055, 3555, 9640, 4117, 34683, 3615, 6027, 7578, 6055, 1829, 1975, 1829, 8608, 33604, 6027, 35186, 4724, 8315, 2655, 22807, 4724, 1829, 3555, 4587, 7578, 8608, 3224, 1211, 2423, 4230, 992, 1975, 8315, 4724, 24401, 3215, 9154, 4032, 9957, 4032, 9154, 9122, 3215, 3224, 44945, 16606, 15844, 2423, 2517, 13672, 1829, 39894, 5016, 16254, 11778, 1829, 8717, 25957, 21984, 6055, 28820, 6225, 31845, 10632], "avg_logprob": -0.25469770306855244, "compression_ratio": 2.044368600682594, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 2689.0499999999997, "end": 2689.49, "word": "بتحتوى", "probability": 0.75068359375}, {"start": 2689.49, "end": 2689.63, "word": " الـ", "probability": 0.57080078125}, {"start": 2689.63, "end": 2689.73, "word": " D", "probability": 0.4736328125}, {"start": 2689.73, "end": 2690.51, "word": " طب", "probability": 0.438720703125}, {"start": 2690.51, "end": 2690.59, "word": " و", "probability": 0.498291015625}, {"start": 2690.59, "end": 2690.69, "word": " ال", "probability": 0.96630859375}, {"start": 2690.69, "end": 2691.05, "word": " first", "probability": 0.83740234375}, {"start": 2691.05, "end": 2691.79, "word": " و", "probability": 0.74072265625}, {"start": 2691.79, "end": 2691.89, "word": " ال", "probability": 0.95849609375}, {"start": 2691.89, "end": 2692.15, "word": " last", "probability": 0.90576171875}, {"start": 2692.15, "end": 2692.33, "word": " ال", "probability": 0.51416015625}, {"start": 2692.33, "end": 2692.63, "word": " first", "probability": 0.787109375}, {"start": 2692.63, "end": 2693.05, "word": " element", "probability": 0.94287109375}, {"start": 2693.05, "end": 2693.23, "word": " و", "probability": 0.9609375}, {"start": 2693.23, "end": 2693.33, "word": " ال", "probability": 0.94580078125}, {"start": 2693.33, "end": 2693.55, "word": " last", "probability": 0.927734375}, {"start": 2693.55, "end": 2693.85, "word": " element", "probability": 0.96630859375}, {"start": 2693.85, "end": 2694.01, "word": " اللي", "probability": 0.938232421875}, {"start": 2694.01, "end": 2694.53, "word": " موجودين", "probability": 0.96533203125}, {"start": 2694.53, "end": 2694.91, "word": " على", "probability": 0.76611328125}, {"start": 2694.91, "end": 2695.03, "word": " ال", "probability": 0.947265625}, {"start": 2695.03, "end": 2695.13, "word": " tree", "probability": 0.7041015625}, {"start": 2695.13, "end": 2695.35, "word": " تعالى", "probability": 0.7950846354166666}, {"start": 2695.35, "end": 2695.55, "word": " نشوف", "probability": 0.9931640625}, {"start": 2695.55, "end": 2695.69, "word": " ال", "probability": 0.599609375}, {"start": 2695.69, "end": 2695.81, "word": " code", "probability": 0.96044921875}, {"start": 2695.81, "end": 2695.95, "word": " هذا", "probability": 0.62451171875}, {"start": 2695.95, "end": 2696.07, "word": " على", "probability": 0.86962890625}, {"start": 2696.07, "end": 2696.51, "word": " السريع", "probability": 0.9716796875}, {"start": 2696.51, "end": 2697.37, "word": " المحاضرة", "probability": 0.9794921875}, {"start": 2697.37, "end": 2697.63, "word": " الجاية", "probability": 0.7150065104166666}, {"start": 2697.63, "end": 2697.75, "word": " ان", "probability": 0.7998046875}, {"start": 2697.75, "end": 2697.89, "word": " شاء", "probability": 0.962890625}, {"start": 2697.89, "end": 2697.93, "word": " الله", "probability": 0.96630859375}, {"start": 2697.93, "end": 2698.29, "word": " تعالى", "probability": 0.9715169270833334}, {"start": 2698.29, "end": 2698.47, "word": " لأن", "probability": 0.735107421875}, {"start": 2698.47, "end": 2698.71, "word": " الوقت", "probability": 0.9361979166666666}, {"start": 2698.71, "end": 2699.25, "word": " أدركنا", "probability": 0.8558349609375}, {"start": 2699.25, "end": 2700.97, "word": " بنبدأ", "probability": 0.7845052083333334}, {"start": 2700.97, "end": 2701.11, "word": " من", "probability": 0.97900390625}, {"start": 2701.11, "end": 2701.39, "word": " عند", "probability": 0.990234375}, {"start": 2701.39, "end": 2701.67, "word": " ال", "probability": 0.9609375}, {"start": 2701.67, "end": 2701.89, "word": " sets", "probability": 0.908203125}, {"start": 2701.89, "end": 2701.97, "word": " و", "probability": 0.9677734375}, {"start": 2701.97, "end": 2702.35, "word": " بنتكلم", "probability": 0.9342041015625}, {"start": 2702.35, "end": 2702.61, "word": " على", "probability": 0.7333984375}, {"start": 2702.61, "end": 2702.77, "word": " ال", "probability": 0.9755859375}, {"start": 2702.77, "end": 2702.93, "word": " tree", "probability": 0.65576171875}, {"start": 2702.93, "end": 2703.35, "word": " set", "probability": 0.88330078125}, {"start": 2703.35, "end": 2703.75, "word": " ان", "probability": 0.783203125}, {"start": 2703.75, "end": 2703.89, "word": " شاء", "probability": 0.98095703125}, {"start": 2703.89, "end": 2703.97, "word": " الله", "probability": 0.9609375}, {"start": 2703.97, "end": 2704.31, "word": " تبارك", "probability": 0.8963623046875}, {"start": 2704.31, "end": 2704.87, "word": " وتعالى", "probability": 0.947998046875}, {"start": 2704.87, "end": 2705.15, "word": " تي", "probability": 0.2828369140625}, {"start": 2705.15, "end": 2705.25, "word": " اي", "probability": 0.752685546875}, {"start": 2705.25, "end": 2705.47, "word": " سؤال", "probability": 0.9899088541666666}, {"start": 2705.47, "end": 2705.55, "word": " يا", "probability": 0.8623046875}, {"start": 2705.55, "end": 2706.67, "word": " بنات؟", "probability": 0.76568603515625}, {"start": 2706.67, "end": 2706.97, "word": " بيبقى", "probability": 0.659521484375}, {"start": 2706.97, "end": 2707.33, "word": " سهل", "probability": 0.7705078125}, {"start": 2707.33, "end": 2707.47, "word": " ال", "probability": 0.900390625}, {"start": 2707.47, "end": 2707.67, "word": " tree", "probability": 0.78173828125}, {"start": 2707.67, "end": 2707.91, "word": " set", "probability": 0.92724609375}, {"start": 2707.91, "end": 2708.13, "word": " انا", 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a7a5ff354dbbd5a4d66befd1fdb4f08b23710868
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/py5PlkAfGdw_raw.srt
@@ -0,0 +1,2276 @@
+1
+00:00:20,750 --> 00:00:22,630
+بسم الله والحمد لله والصلاة والسلام علي رسول الله
+
+2
+00:00:22,630 --> 00:00:25,230
+اليوم ان شاء الله يا بنات هنتكلم على ال Java
+
+3
+00:00:25,230 --> 00:00:29,550
+collections موضوع مهم و من المواضيع اللي رفعت ال
+
+4
+00:00:29,550 --> 00:00:33,430
+Java لفوق و خصوصا لما نسينا ان نتكلم عن ال generic
+
+5
+00:00:33,430 --> 00:00:39,910
+program الآن ال Java collection بتكلم على واحدة من
+
+6
+00:00:39,910 --> 00:00:43,270
+ال data structures من تركيب البيانات و المفروض ان
+
+7
+00:00:43,270 --> 00:00:48,810
+انت اما خلصت data structure او تردسيها حالياإيش
+
+8
+00:00:48,810 --> 00:00:52,110
+فكرتها إن هذا ال object اللي هو ال collection بدي
+
+9
+00:00:52,110 --> 00:00:57,170
+شير لمين؟ reference ل object آخر وهذا الكلام
+
+10
+00:00:57,170 --> 00:01:02,250
+بيعطينا مفهوم مهم جدا إن ال contents تبع ال
+
+11
+00:01:02,250 --> 00:01:06,330
+collection عبارة عن reference data type not
+
+12
+00:01:06,330 --> 00:01:12,510
+primitive data type تمام؟ وبالتالي إيش نوع ال
+
+13
+00:01:12,510 --> 00:01:16,520
+object اللي أنا ممكن أشيرله؟أي object أبسطها الـ
+
+14
+00:01:16,520 --> 00:01:19,820
+string اللي بنعرفه لك ممكن يكون ال collection عنده
+
+15
+00:01:19,820 --> 00:01:22,180
+collection of employees collection of cars
+
+16
+00:01:22,180 --> 00:01:24,800
+collection of students حسب ال data type اللي
+
+17
+00:01:24,800 --> 00:01:32,260
+موجودة وبالتالي ال object هذا ممكن يكون من أي type
+
+18
+00:01:32,260 --> 00:01:41,080
+is a relationship يعني أنا فيه عندي employeeوفي
+
+19
+00:01:41,080 --> 00:01:43,680
+عندي part-time employee وفي عندي full-time
+
+20
+00:01:43,680 --> 00:01:47,240
+employee، مظبوط؟ إيش العلاقة بينهم؟ ال part-time
+
+21
+00:01:47,240 --> 00:01:51,280
+employee is a employee و ال full-time is an
+
+22
+00:01:51,280 --> 00:01:54,840
+employee يعني لو عملت collection .. collection من
+
+23
+00:01:54,840 --> 00:02:00,500
+ال employee بقدر يشير .. يشير لمين؟ يشير على full
+
+24
+00:02:00,500 --> 00:02:03,120
+-time و يقدر يشير على ال part-time لأن عبارة عن
+
+25
+00:02:03,120 --> 00:02:07,390
+العلاقة بينهم isdata structure إيش يعني generate
+
+26
+00:02:07,390 --> 00:02:10,710
+data structure؟ إنها مش مرتبطة بنوع معين من
+
+27
+00:02:10,710 --> 00:02:15,010
+البيانات مش مرتبطة بنوع معين من البيانات وبالتالي
+
+28
+00:02:15,010 --> 00:02:20,530
+بقدر ال list هذه تحتوي أي نوع من ال objects اللي
+
+29
+00:02:20,530 --> 00:02:24,490
+ممكن يخطر على بالك طيب السؤال اللي بيطرح نفسه لو
+
+30
+00:02:24,490 --> 00:02:28,410
+أنا بدي array أو بدي collection of integers شو بدي
+
+31
+00:02:28,410 --> 00:02:31,810
+أسوي؟
+
+32
+00:02:31,810 --> 00:02:36,320
+الآن أنا بدي على سبيل المثال بدي listوال data
+
+33
+00:02:36,320 --> 00:02:41,000
+تابعتها integer هذا
+
+34
+00:02:41,000 --> 00:02:46,140
+الكلام مستحيل يصير ليش؟ لأن هذا primitive data بس
+
+35
+00:02:46,140 --> 00:02:53,280
+مرت علينا في البداية ال rubber class اللي
+
+36
+00:02:53,280 --> 00:03:00,580
+هو integer وبالتالي ممكن انا اعمل collection of
+
+37
+00:03:00,580 --> 00:03:03,060
+integers لكن باعتمادي على ال rubber class تبع ال
+
+38
+00:03:03,060 --> 00:03:06,810
+integerمش على الـ Primitive Data اللي موجودة عندنا
+
+39
+00:03:06,810 --> 00:03:11,990
+تمام من
+
+40
+00:03:11,990 --> 00:03:14,730
+ال collections اللي موجودة عندى مجموعة ال
+
+41
+00:03:14,730 --> 00:03:20,670
+interfaces collection set list map و queue وانت
+
+42
+00:03:20,670 --> 00:03:23,130
+المفروض في ال data structure مرّت عليك شو يعني
+
+43
+00:03:23,130 --> 00:03:25,640
+queueواستخدمتيها بالـ Java وعملتي الـ
+
+44
+00:03:25,640 --> 00:03:28,560
+implementation بالـ Java و stack و link list إلى
+
+45
+00:03:28,560 --> 00:03:33,020
+آخرهم من العناصر الموجودة أنا هركز اليوم على أو في
+
+46
+00:03:33,020 --> 00:03:35,400
+محاضرة نهادة مع ال collections على التلات عناصر
+
+47
+00:03:35,400 --> 00:03:40,160
+الموجودة اللي هي ال set و ال list و ال map و هشوف
+
+48
+00:03:40,160 --> 00:03:43,280
+كيف ممكن أستفيد من ال route interface اللي موجود
+
+49
+00:03:43,280 --> 00:03:46,800
+عندي اللي هي ال collection و ال class او ال
+
+50
+00:03:46,800 --> 00:03:49,420
+general class اللي انبنى او ال super class اللي تم
+
+51
+00:03:49,420 --> 00:03:53,650
+بناءه على ال interface اللي موجود عندهاcollection
+
+52
+00:03:53,650 --> 00:03:58,490
+interface و collections class طبعا عادة انا مش هدق
+
+53
+00:03:58,490 --> 00:04:02,470
+معاكي على ال spelling كتير خصوصا عندما تكتب ..
+
+54
+00:04:02,470 --> 00:04:05,950
+خليك تكتب code بس بدك تنتبه من البداية ان انا في
+
+55
+00:04:05,950 --> 00:04:09,770
+عند collection بتمثل interface و في عند
+
+56
+00:04:09,770 --> 00:04:13,610
+collections بتمثل class وبالتالي ال calling لهذه
+
+57
+00:04:14,470 --> 00:04:17,470
+غير، يعني أنا الآن ممكن أstudy ال collections و
+
+58
+00:04:17,470 --> 00:04:20,110
+أstudy كل ال static method اللي في داخلها لكن
+
+59
+00:04:20,110 --> 00:04:23,130
+ماقدرش أستفيد من ال collection اللي جاريه من خلال
+
+60
+00:04:23,130 --> 00:04:28,410
+ال implementation طيب ال interface collection لأن
+
+61
+00:04:28,410 --> 00:04:31,910
+هو الأساس عامل implementation لمجموعة من ال method
+
+62
+00:04:31,910 --> 00:04:37,270
+اللي لها علاقة بعض بالاشبالإضافة والمسح والمقارنة
+
+63
+00:04:37,270 --> 00:04:40,750
+ما بين عناصر ال collection اللي موجودة يعني أنا
+
+64
+00:04:40,750 --> 00:04:47,590
+بتكلم على group of objects اول
+
+65
+00:04:47,590 --> 00:04:51,090
+حاجة ال collection can be converted to array
+
+66
+00:04:51,090 --> 00:04:59,510
+والعكس صحيح مرت عليك شغل اسمها arrays class dot في
+
+67
+00:04:59,510 --> 00:05:03,260
+عندنا شغل اسمها as listأو method اسمها as list
+
+68
+00:05:03,260 --> 00:05:08,500
+بتاخد مني array و بترجعلي الاش؟ بترجعلي list
+
+69
+00:05:08,500 --> 00:05:13,420
+بترجعلي list هنشوفها خلال ال code اللي موجود لكن
+
+70
+00:05:13,420 --> 00:05:17,160
+أهميتها أنه فعليا أنا بقدر أحول ال collection ل
+
+71
+00:05:17,160 --> 00:05:21,460
+array و العكس صحيح و بحور ال array ل collection
+
+72
+00:05:21,460 --> 00:05:21,960
+كذلك
+
+73
+00:05:27,930 --> 00:05:32,670
+الـ Interface Collection بيزودني بـ Iterator
+
+74
+00:05:32,670 --> 00:05:36,550
+بيزودني بـ Iterator إيش الـ Iterator؟ قولنا هو
+
+75
+00:05:36,550 --> 00:05:41,750
+عبارة عن application أو counter بيمكنني أني أمر
+
+76
+00:05:41,750 --> 00:05:45,330
+على عناصر الـ list أو ال collection اللي موجود
+
+77
+00:05:45,330 --> 00:05:50,390
+وشوفنا وين؟ مع ال scanner لمش قولنا كنا قوله while
+
+78
+00:05:50,390 --> 00:06:00,150
+ال scanner object dot hasnext أو has next line
+
+79
+00:06:00,150 --> 00:06:04,850
+الآن
+
+80
+00:06:04,850 --> 00:06:09,910
+هذا بنسميه iterator ايش ال iterator؟ هو عبارة عن
+
+81
+00:06:09,910 --> 00:06:14,290
+object بمور على كل عناصر ال collection على كل
+
+82
+00:06:14,290 --> 00:06:19,270
+عناصر ال collection ودر بالك هذه من أهم الميزات
+
+83
+00:06:19,270 --> 00:06:23,430
+اللي بتفرج بين ال scanner و ال buffered reader
+
+84
+00:06:25,610 --> 00:06:29,010
+وبالتالي وجود الـ iterator عشان انا أستفيد منه
+
+85
+00:06:29,010 --> 00:06:35,010
+ماهو الـ iterator؟ هو عبارة عن object بيخلّي
+
+86
+00:06:35,010 --> 00:06:38,770
+البرنامج يمر عبر عناصر الـ collection كلها element
+
+87
+00:06:38,770 --> 00:06:45,910
+إلى element وبقدر من خلاله أعمل remove لل element
+
+88
+00:06:45,910 --> 00:06:49,990
+يعني انت تخيلي ان في عندي list عليها مجموعة من
+
+89
+00:06:49,990 --> 00:06:54,270
+الألوان R أو Red أو Green
+
+90
+00:06:57,980 --> 00:07:02,060
+Blue هاي ال RGB وهاي في عندي مثلا ال white في
+
+91
+00:07:02,060 --> 00:07:05,680
+الآخر ال
+
+92
+00:07:05,680 --> 00:07:12,520
+iterator object عادة يشير لأول element في ال list
+
+93
+00:07:12,520 --> 00:07:16,560
+اللي موجودة عندي هنا في method الأصل تقول ليه في
+
+94
+00:07:16,560 --> 00:07:19,780
+data ولا مفيش يعني ال iterator الأصل يكون فيه dot
+
+95
+00:07:19,780 --> 00:07:23,360
+has next زي ما شوفنا مع ال scanner هذه Boolean
+
+96
+00:07:23,360 --> 00:07:28,820
+functionالان لما انا بقوله الـ iterator.next
+
+97
+00:07:28,820 --> 00:07:34,820
+مباشرة بيرجعلي ب object من نفس ال data type اللي
+
+98
+00:07:34,820 --> 00:07:39,200
+انبنت علي يمين ال collection hand string هيرجع
+
+99
+00:07:39,200 --> 00:07:44,280
+bred و مباشرة ال iterator هيتحرك للأمام خطوة عشان
+
+100
+00:07:44,280 --> 00:07:48,320
+هيك بنقول احنا ال walks through the collections
+
+101
+00:07:48,320 --> 00:07:51,920
+element بمشي من خلال ال element بظل يمشي لما متى
+
+102
+00:07:51,920 --> 00:07:56,910
+يصلالنغل اللي في الآخر مافيش element معناته هتكون
+
+103
+00:07:56,910 --> 00:08:02,930
+ال method has next ال iterator dot has next بترجع
+
+104
+00:08:02,930 --> 00:08:07,610
+ب false طيب ال current position اللي أنا بقشر عليه
+
+105
+00:08:07,610 --> 00:08:11,430
+بإمكاني زي ما بقرأه بال next ممكن أروح أقوله ال
+
+106
+00:08:11,430 --> 00:08:18,370
+iterator dotremove عشان يحذف ال element هذا من ال
+
+107
+00:08:18,370 --> 00:08:21,590
+collection عشان هيك بقول انه بقدر يمر على عناصر ال
+
+108
+00:08:21,590 --> 00:08:24,990
+collection and remove elements from the collection
+
+109
+00:08:24,990 --> 00:08:32,270
+during the iteration طيب تماممعناته أنا الآن صرت
+
+110
+00:08:32,270 --> 00:08:35,610
+بتكلم على ال data وصار بإمكاني أحصل على iterator
+
+111
+00:08:35,610 --> 00:08:39,770
+أمر عليها وبالطريقة التقليدية اللي إحنا بنعرفها في
+
+112
+00:08:39,770 --> 00:08:43,090
+عند list عدد العناصر اللي فيها خمسة بقدر أعمل for
+
+113
+00:08:43,090 --> 00:08:46,990
+loop و أمر عليهم، أه تقدر غالبا تشتغل من خلال ال
+
+114
+00:08:46,990 --> 00:08:54,670
+index اللي موجود ال collections class بزودني
+
+115
+00:08:54,670 --> 00:08:58,790
+بمجموعة من ال aesthetic methods إيش يعني aesthetic
+
+116
+00:08:58,790 --> 00:08:59,410
+methods؟
+
+117
+00:09:02,920 --> 00:09:06,460
+بقدر أستدعيها بدون مانشي object من ال class اللي
+
+118
+00:09:06,460 --> 00:09:12,560
+موجود عندي هذا يعني بصير أقوله أنا collections هذا
+
+119
+00:09:12,560 --> 00:09:20,320
+اسم ال class dot sort collection dot search حسب
+
+120
+00:09:20,320 --> 00:09:23,260
+إيش ال method اللي موجودة طبعا ما تاخديش اسم ال
+
+121
+00:09:23,260 --> 00:09:26,840
+search و ال sort بال spelling صحيح 100% قدر ما أن
+
+122
+00:09:26,840 --> 00:09:29,780
+عمالي بعبر على إيش ال methods اللي موجودة هذه من
+
+123
+00:09:29,780 --> 00:09:30,980
+أجل البحث وترتيب
+
+124
+00:09:33,730 --> 00:09:37,470
+والشغل اللي ممكن يلزمني على الـ collections start
+
+125
+00:09:37,470 --> 00:09:41,670
+ال sort هي موجودة لكن ال search بالمسمى نفسه شوية
+
+126
+00:09:41,670 --> 00:09:48,350
+هنشوفه تمام ال collections as a framework جمعت
+
+127
+00:09:48,350 --> 00:09:52,750
+مجموعة من ال element مع بعضهم واحنا فعليا هنشوفهم
+
+128
+00:09:52,750 --> 00:09:56,690
+في عند ال collection interface اللي حكينا عنه هيه
+
+129
+00:09:56,690 --> 00:10:04,570
+بنبني عليه interface آخر listو Interface Q ده مش
+
+130
+00:10:04,570 --> 00:10:09,350
+هنطرقله و Interface اسمه set و من ال interface
+
+131
+00:10:09,350 --> 00:10:14,010
+list في عندي array list وفي عندي stack المفروض
+
+132
+00:10:14,010 --> 00:10:17,210
+شوفتيها في ال data structure في عندك list شوفتيها
+
+133
+00:10:17,210 --> 00:10:20,430
+في ال data structure و priority queue شوفتيها في
+
+134
+00:10:20,430 --> 00:10:22,850
+ال data structure وبالتالي أنا مع ال list
+
+135
+00:10:22,850 --> 00:10:26,790
+interface فقط هعتمد على two classes اللي هي ال
+
+136
+00:10:26,790 --> 00:10:29,850
+array list فقط
+
+137
+00:10:30,890 --> 00:10:33,750
+الان في الـ hash أو في ال set في ال interface set
+
+138
+00:10:33,750 --> 00:10:38,190
+في عندي hash set و في عندي tree set طيب، هل في فرق
+
+139
+00:10:38,190 --> 00:10:42,610
+بين ال set و ال list؟ الأصل يكون فيه فرق مرت عليك
+
+140
+00:10:42,610 --> 00:10:46,470
+في ال data structure set؟ عفوا، في ال discrete
+
+141
+00:10:46,470 --> 00:10:50,790
+mathematics، اللي قضيت مفاصلة المجموعات ال sets
+
+142
+00:10:50,790 --> 00:10:58,940
+أهم تعريف فيها إيش كان؟ unordered groupof unique
+
+143
+00:10:58,940 --> 00:11:04,160
+elements عنصر واحد تمنع التكرار تمام؟ وبالتالي
+
+144
+00:11:04,160 --> 00:11:07,460
+فيها different implementation سواء باعتمادنا على
+
+145
+00:11:07,460 --> 00:11:11,480
+ال hash set أو ال tree set سنشوفهم بالاضافة لدي
+
+146
+00:11:11,480 --> 00:11:14,940
+واحد من ال collections اسمه map وانا بتكلم على
+
+147
+00:11:14,940 --> 00:11:22,140
+ordered pairs او ازواج بتكلم على keyو value بتكلم
+
+148
+00:11:22,140 --> 00:11:26,740
+على key و value هنتكلم في حينها على ال maps يعني
+
+149
+00:11:26,740 --> 00:11:30,600
+أنا فعليا هتكلم على three objects من ال
+
+150
+00:11:30,600 --> 00:11:33,840
+collections هتكلم على ال list أو ال array list
+
+151
+00:11:33,840 --> 00:11:41,540
+هتكلم على ال set و هتكلم على ال map هتكلم على ال
+
+152
+00:11:41,540 --> 00:11:48,820
+map الآن
+
+153
+00:11:48,820 --> 00:11:53,430
+لما أنا بتكلم أو نبدأ بال listال list هي عبارة عن
+
+154
+00:11:53,430 --> 00:12:00,350
+ordered collection ordered collection وبديش تفهمي
+
+155
+00:12:00,350 --> 00:12:06,390
+أو بديك تميزي بين sorted و ordered ايش يعني
+
+156
+00:12:06,390 --> 00:12:11,230
+sorted؟ مرتبة ordered مرتبة
+
+157
+00:12:12,230 --> 00:12:16,270
+أيوة، بس الآن أنا ببتكلم ordered يعني قاعد ببتكلم
+
+158
+00:12:16,270 --> 00:12:20,890
+على الترتيب، ترتيب العراصر حسب أو .. أو ليه وليت
+
+159
+00:12:20,890 --> 00:12:24,710
+قدومها أو حسب قدومها أو وجودها في ال list باشي
+
+160
+00:12:24,710 --> 00:12:28,450
+بقول العنصر الأول في ال list، الآن كمان مرة، نرجع
+
+161
+00:12:28,450 --> 00:12:37,390
+للألوان R أو Red، Green، Blue، اللي هي ال RGB
+
+162
+00:12:37,390 --> 00:12:42,820
+colorsالان لو انا هدول العناصر موجودين في list
+
+163
+00:12:42,820 --> 00:12:49,020
+بقول عنهم ordered العنصر الأول مين؟ Red، التاني
+
+164
+00:12:49,020 --> 00:12:53,460
+Green، التالت بلو و هكذا الأول، التاني، التالت،
+
+165
+00:12:53,460 --> 00:12:57,900
+هذه المفهوم في ordering عشان نعمل ترتيب أو ندّر
+
+166
+00:12:57,900 --> 00:13:02,940
+label لكن لما باجي بتكلم على sorted بدي ارتبهم
+
+167
+00:13:02,940 --> 00:13:07,240
+تبعا ل criteria معينةبدي أرتبهم على كريتيريا معينة
+
+168
+00:13:07,240 --> 00:13:11,300
+حسب .. هنا ممكن أقول الـ alphabetical character
+
+169
+00:13:11,300 --> 00:13:14,600
+بتيجي blue في الأول بعدين green بعدين red لأنه
+
+170
+00:13:14,600 --> 00:13:18,920
+بناء على الحرف لكن ممكن برضه أتكلم أنا بناء على ال
+
+171
+00:13:18,920 --> 00:13:22,600
+size ال string size أعملهم ordering تبع ال size
+
+172
+00:13:22,600 --> 00:13:27,320
+تيجي red تيجي blue بعدين تيجي وراها green في ال
+
+173
+00:13:27,320 --> 00:13:32,210
+sorted لازم يكون في sorting criteriaفي الـ ordered
+
+174
+00:13:32,210 --> 00:13:36,090
+كل element بيجي بياخد ال position وبياخد الترتيب
+
+175
+00:13:36,090 --> 00:13:46,110
+اللي هو إجا فيه بالإضافة
+
+176
+00:13:46,110 --> 00:13:50,410
+لـ inherited from ال collection ال list هتزود
+
+177
+00:13:50,410 --> 00:13:55,710
+مجموعة من العناصر اللي ممكن تعمل manipulate لل
+
+178
+00:13:55,710 --> 00:14:02,750
+elements من خلال ال indexأنا عندي list فيها خمس
+
+179
+00:14:02,750 --> 00:14:06,090
+عناصر بقدر أتعامل مع ال list من خلال ال index أه
+
+180
+00:14:06,090 --> 00:14:10,450
+بقدر لأن هي ordered لأن هي ordered يعني في عندي
+
+181
+00:14:10,450 --> 00:14:14,190
+position واحد اتنين تلاتة يعني في عندي index و
+
+182
+00:14:14,190 --> 00:14:19,030
+بقدر أستفيد منه search for element يعني بقدر أدور
+
+183
+00:14:19,030 --> 00:14:23,290
+لأن طالما في عندي index بقدر أعمل loopو بقدر امر
+
+184
+00:14:23,290 --> 00:14:27,450
+على العناصر اللي موجودة عندها بالاضافة بقدر احصل
+
+185
+00:14:27,450 --> 00:14:31,770
+على list iterator عشان امر على عناصر ال list اللي
+
+186
+00:14:31,770 --> 00:14:36,070
+موجودة عندها ال interface اللي اسمه list انه عمله
+
+187
+00:14:36,070 --> 00:14:40,670
+implementation من different classes الray list
+
+188
+00:14:40,670 --> 00:14:47,330
+link list و ال vector كلهم list كلهم عبارة عن list
+
+189
+00:14:48,600 --> 00:14:55,420
+الـ link list الأصل إنه كل object بيحتوي على ال
+
+190
+00:14:55,420 --> 00:14:59,940
+data اللي هي ال value ومؤشر أو pointer to next
+
+191
+00:14:59,940 --> 00:15:04,620
+object، مصبوط؟ يعني هيك بجنه نسميه كل object هو
+
+192
+00:15:04,620 --> 00:15:11,340
+عبارة عن node ال node بتحتوي على مشاقين data و
+
+193
+00:15:11,340 --> 00:15:18,600
+next node، مصبوط؟ و next node pointer، تمامالان
+
+194
+00:15:18,600 --> 00:15:23,260
+بقى عندى ال array list و ال vector ال array list و
+
+195
+00:15:23,260 --> 00:15:26,680
+ال vector هذه بتحتوي data و هذه بتحتوي data هذه
+
+196
+00:15:26,680 --> 00:15:31,500
+بتحتوي على pointers انا مابديش اياهم الان طيب الان
+
+197
+00:15:31,500 --> 00:15:36,360
+عشان اسأل او ايش الفرق اللى بين ال vector و ال
+
+198
+00:15:36,360 --> 00:15:44,920
+array list الفرق بكل بساطة ان ال data او ال vector
+
+199
+00:15:48,750 --> 00:15:54,530
+عادةً Synchronized ايش Synchronized؟ متزامن ومفهوم
+
+200
+00:15:54,530 --> 00:15:59,170
+التزامن في ال threading لحظة احنا روحنا علوان على
+
+201
+00:15:59,170 --> 00:16:06,490
+شغل اسمها multi threads او multi threading انه انا
+
+202
+00:16:06,490 --> 00:16:11,290
+اخلي ال application تبعي بدل ما كان بيشتغل ب one
+
+203
+00:16:11,290 --> 00:16:16,270
+flow في مرحلة من المراحل اروح اعمله اعمله split
+
+204
+00:16:19,760 --> 00:16:23,540
+يشتغل و بعد ذلك ممكن انا اجمع ال data في point
+
+205
+00:16:23,540 --> 00:16:27,800
+واحدة او اكمل هذه مرحلة ال split بنسميها ايش او كل
+
+206
+00:16:27,800 --> 00:16:34,320
+split بنسميها thread الفكرة فيها ان احصل على اداء
+
+207
+00:16:34,320 --> 00:16:38,420
+افضل لل application تبعي عبر اعطاء او خلال ال
+
+208
+00:16:38,420 --> 00:16:42,080
+application تبعي يدّي مهام اكتر لل CPU لان ال CPU
+
+209
+00:16:42,080 --> 00:16:46,520
+لان لما اتكلم البرنامج او اللي عندي core i7 و
+
+210
+00:16:46,520 --> 00:16:50,400
+جاعدين بتكلموا على تمانية coreأنا بالوضع التقييدي
+
+211
+00:16:50,400 --> 00:16:53,220
+في البرنامج تابع بشغل على one core هل في ممكن
+
+212
+00:16:53,220 --> 00:16:58,410
+أستفيد من ال course التانية؟ طيبهذه المفروضة الـ
+
+213
+00:16:58,410 --> 00:17:02,070
+Parallel الآن إذا أنا بدي أستفيد منها معناته بدي
+
+214
+00:17:02,070 --> 00:17:05,770
+يكون برنامجي عنده القدرة إنه ينفذ مجموعة من ال
+
+215
+00:17:05,770 --> 00:17:10,110
+task بشكل إيش متزامن عشان يقدر يستفيد من المعالج
+
+216
+00:17:10,110 --> 00:17:14,030
+بشكل كامل يستفيد من ال cores بشكل مكتمل الشغل
+
+217
+00:17:14,030 --> 00:17:17,530
+التاني حتى لو كان عندي one core عادة ال operating
+
+218
+00:17:17,530 --> 00:17:21,050
+system مش بروح بساوي بروح بيعمل scheduling لوقت
+
+219
+00:17:21,050 --> 00:17:24,950
+المعالج والمعالج سريع جدا، بصبت؟ وغالبا بكون
+
+220
+00:17:24,950 --> 00:17:30,830
+ideal، مابشتغلشأيش الحل؟ أن أخلّي برنامجي ينفذ
+
+221
+00:17:30,830 --> 00:17:34,330
+أكتر من task في نفس الواجهة فبصير بدل ما ال
+
+222
+00:17:34,330 --> 00:17:38,130
+operating system بدي ال application تبعي one slice
+
+223
+00:17:38,130 --> 00:17:41,630
+of thyme بروح بديتين، تين و تلاتة أو أربعة بس كل
+
+224
+00:17:41,630 --> 00:17:46,430
+واحدة اللحظة بتاخد different task هذا بنسمي multi
+
+225
+00:17:46,430 --> 00:17:50,450
+-threading الآن في الموضوع الـSynchronized لو كان
+
+226
+00:17:50,450 --> 00:17:53,950
+عندي thread أو two threads بدهم يصلوا لنفس ال
+
+227
+00:17:53,950 --> 00:17:58,490
+object of dataماذا سيحدث فيه؟ إذا قلت له
+
+228
+00:17:58,490 --> 00:18:04,530
+Synchronized فهو سيبحث عن الـ data هذه لحد ما ال
+
+229
+00:18:04,530 --> 00:18:07,970
+thread اللي مسكها في الأول يعمل release وهذا لما
+
+230
+00:18:07,970 --> 00:18:10,970
+تكون ال data critical والـ update عليها مهم لكل
+
+231
+00:18:10,970 --> 00:18:14,210
+يشوفه تخيّلي .. تخيّلي .. أنا في عندي two
+
+232
+00:18:14,210 --> 00:18:20,430
+different thread T1 و T2 هدولة بمثله teller في بنك
+
+233
+00:18:20,430 --> 00:18:26,410
+تمام؟ بمثله teller في بنك و بدهم يعملوا axisعلى
+
+234
+00:18:26,410 --> 00:18:33,450
+نفس الـ record في نفس الوقت الـ account و بدهم
+
+235
+00:18:33,450 --> 00:18:39,550
+يروحوا يعملوا with a draw بدهم يعملوا سحب هنا صاحب
+
+236
+00:18:39,550 --> 00:18:42,990
+الرصيد موجود في البنك اللي في الفرع المدينة اللي
+
+237
+00:18:42,990 --> 00:18:50,450
+موجود و عميل إله أو زبون آخر مع شيك بده يسحب و
+
+238
+00:18:50,450 --> 00:18:55,590
+ربنا قدر إن الاتنين دخلوا في نفس الوقتلأنه ممكن
+
+239
+00:18:55,590 --> 00:19:02,370
+يبقى في مشكلة لو كان الرصيد غير كافي ولا لأ تخيل
+
+240
+00:19:02,370 --> 00:19:07,730
+أن الرصيد فقط بيحتوي على ألف دولار وقيمة الشك هذا
+
+241
+00:19:07,730 --> 00:19:13,350
+معاها شك بـ 700 دولار وهذا بده يسحب 400 دولار
+
+242
+00:19:13,350 --> 00:19:19,970
+الأصل لو مافيش look أو مافيش synchronizationعلى
+
+243
+00:19:19,970 --> 00:19:22,930
+الـ record هذا، ماذا سيحدث؟ الـ tiller hand شاف
+
+244
+00:19:22,930 --> 00:19:26,870
+الرصيد ألف و ال tiller hand اللي شاف الرصيد ألف،
+
+245
+00:19:26,870 --> 00:19:31,730
+معناته العملية okay proved فسحب لهذا سبعمية و سحب
+
+246
+00:19:31,730 --> 00:19:36,970
+لهذا أربعمية فبيصير رصيد ال hand minus سالب مية،
+
+247
+00:19:36,970 --> 00:19:41,610
+بصبوط ولا لأ؟ بس هذا الكلام not allowed فإيش الحل؟
+
+248
+00:19:41,610 --> 00:19:45,190
+حتما في واحد من اتنين وصل لل resource قبل، صح؟
+
+249
+00:19:45,970 --> 00:19:48,950
+مفهوم الـ Synchronized أنه بمجرد تمسك ال data
+
+250
+00:19:48,950 --> 00:19:54,110
+source تعمل عليه lock يعني تمنع أي حد تاني يصلّه
+
+251
+00:19:54,110 --> 00:19:57,530
+لحد ما انا اعمله release وبالتالي الفرق .. احنا
+
+252
+00:19:57,530 --> 00:19:59,990
+بنعرف نشتغل ال system بنشتغل بال nano second
+
+253
+00:19:59,990 --> 00:20:04,370
+وبالتالي الفرق الزمني هيكون موجود بين ال tasks و
+
+254
+00:20:04,370 --> 00:20:07,930
+بقدر اعمل lock by default ال vector هو عبارة عن
+
+255
+00:20:07,930 --> 00:20:11,590
+Synchronized by default لكنه
+
+256
+00:20:13,060 --> 00:20:16,500
+الـ Unrealist، الـ Unrealist لأ طبعا لما أنا بتكلم
+
+257
+00:20:16,500 --> 00:20:19,920
+على الـ Synchronized و بدّي أعمل ال thread weight
+
+258
+00:20:19,920 --> 00:20:22,940
+معناته أنا فيه عندي ال time ال system تبعي مش
+
+259
+00:20:22,940 --> 00:20:26,380
+هيقدر يشتغل بالقدرة اللي كان بعته كاملة عشان هيك
+
+260
+00:20:26,380 --> 00:20:31,280
+بنقول في الـ Unsynchronized ال performance أفضل في
+
+261
+00:20:31,280 --> 00:20:35,660
+ال Unsynchronized بنقول ال performance أفضل لكنه
+
+262
+00:20:35,660 --> 00:20:38,880
+في ال Synchronized data أو ال Synchronized object
+
+263
+00:20:39,920 --> 00:20:42,980
+بكون متكلم على safer more safer ان ال data محمية
+
+264
+00:20:42,980 --> 00:20:45,920
+اكثر وبالتالي انا مافيش عندى مشكلة في ال system
+
+265
+00:20:45,920 --> 00:20:48,780
+هنتكلم عليها بالتفصيل ان شاء الله لما نتقل للموضوع
+
+266
+00:20:48,780 --> 00:20:53,500
+ال multi-threading احنا في ال collections هنركز
+
+267
+00:20:53,500 --> 00:21:00,790
+على ال unrealist هنركز على ال unrealistطيب من ال
+
+268
+00:21:00,790 --> 00:21:04,130
+array list interface أو عفوًا ال class أنا عندي
+
+269
+00:21:04,130 --> 00:21:10,310
+add و size و get add من اسمها تعمل إضافة لعنصر على
+
+270
+00:21:10,310 --> 00:21:15,390
+ال list يعني بروح بقوله ال list تبعتي او ال array
+
+271
+00:21:15,390 --> 00:21:24,430
+list dot add read الان أول element read dot add
+
+272
+00:21:24,430 --> 00:21:26,350
+white
+
+273
+00:21:27,830 --> 00:21:33,310
+الـ element التاني هيكون white size بترجعلي بحجم
+
+274
+00:21:33,310 --> 00:21:35,350
+ال list كام element في ال list الموجودة بترجع ب
+
+275
+00:21:35,350 --> 00:21:41,670
+integer get بترجع ب object من ال list اللي عندي
+
+276
+00:21:41,670 --> 00:21:47,850
+حسب ال index المُعضَى حسب ال index المُعضَى وبما
+
+277
+00:21:47,850 --> 00:21:51,930
+أن ال array list هي عبارة عاملة implementation لل
+
+278
+00:21:51,930 --> 00:21:56,430
+collection interface معناته أنا فيه عندي contents
+
+279
+00:21:58,540 --> 00:22:04,660
+بوليان فانكشن بترجع
+
+280
+00:22:04,660 --> 00:22:08,480
+بـ true لما بتكون ال element موجود زي ما شوفنا مع
+
+281
+00:22:08,480 --> 00:22:12,460
+ال folder و ال file مع ال file is a file is exist
+
+282
+00:22:12,460 --> 00:22:16,300
+او exist مظبوط الآن ال method التاني اسمها
+
+283
+00:22:16,300 --> 00:22:20,960
+iterator عشان ترجعلي ب iterator object على ال
+
+284
+00:22:20,960 --> 00:22:24,760
+lists اللي موجودة عندى هان ال iterator object
+
+285
+00:22:24,760 --> 00:22:31,320
+هيكون فيه عندىالـ main method هدول has next بوليان
+
+286
+00:22:31,320 --> 00:22:33,420
+function عشان تتأكد دائما في element في ال
+
+287
+00:22:33,420 --> 00:22:38,540
+iterator next عشان تعمل obtain لل current element
+
+288
+00:22:38,540 --> 00:22:41,540
+في ال iterator و remove تعمل remove لل current
+
+289
+00:22:41,540 --> 00:22:50,540
+element على ال iterator اللي موجود عندها نعم؟ تخيل
+
+290
+00:22:50,540 --> 00:22:51,160
+ال iterator
+
+291
+00:23:01,380 --> 00:23:08,920
+بدأت color list ولا array اللي فوق خالص اللي هي ال
+
+292
+00:23:08,920 --> 00:23:13,880
+colors array فيها تلت ألوان لأن أعرفت array list
+
+293
+00:23:13,880 --> 00:23:18,640
+هي color list سميتها array list من نوع string طب و
+
+294
+00:23:18,640 --> 00:23:21,640
+لاحظوا السطر اللي معموله ال comment فوق إيش نوعه
+
+295
+00:23:21,640 --> 00:23:27,900
+list correct أو color list equal new array list من
+
+296
+00:23:27,900 --> 00:23:33,500
+ال string لاحظوا إن في البدايةلازم اعرف ال data
+
+297
+00:23:33,500 --> 00:23:38,040
+type معاها، تمام؟ طيب السؤال ال commented line صح
+
+298
+00:23:38,040 --> 00:23:49,800
+ولا غلط؟ ال commented line هذا صح ولا غلط؟ ايوة،
+
+299
+00:23:49,800 --> 00:23:53,460
+هذه عبارة عن subclass من ال list وبالتالي العلاقة
+
+300
+00:23:53,460 --> 00:23:57,660
+بينهم is a وبالتالي مافيش فيها مشكلة، ال line صحيح
+
+301
+00:23:57,660 --> 00:24:07,110
+مئة في المئة، تمامبدي أضيف عناصر ال array على ال
+
+302
+00:24:07,110 --> 00:24:09,650
+list اللي موجودة عندي هنا ممكن أعمل ال loop
+
+303
+00:24:09,650 --> 00:24:15,030
+العادية iterator i equals 0 أقل من ال length من
+
+304
+00:24:15,030 --> 00:24:21,370
+تبع ال color بس plus color list dot add ال colors
+
+305
+00:24:21,370 --> 00:24:26,470
+of i طريقة تانية ممكن أروح أعمل for
+
+306
+00:24:32,270 --> 00:24:39,370
+string s في مين؟ أو الـ C في ال killers صح؟ ماشي
+
+307
+00:24:39,370 --> 00:24:46,690
+راح أقوله ال dot add ال C أو ال S مش قضية كتير
+
+308
+00:24:46,690 --> 00:24:49,470
+وبالتالي يعني اللوب هذا يقدر يعملها implementation
+
+309
+00:24:49,470 --> 00:24:53,690
+بال 4H contains
+
+310
+00:24:53,690 --> 00:24:57,280
+قلنا بترجع ب trueلو كان ال color موجود او لو كان
+
+311
+00:24:57,280 --> 00:25:00,760
+ال object موجود ال color list dot contains it true
+
+312
+00:25:00,760 --> 00:25:06,220
+white هترجع ب false نفي ال false true يعني لو كان
+
+313
+00:25:06,220 --> 00:25:13,700
+اللون مش موجود اضيفه لو
+
+314
+00:25:13,700 --> 00:25:17,460
+انا بدى اطبع ال array او ال array list اللى عندى
+
+315
+00:25:17,460 --> 00:25:22,160
+ممكن اطبعهم element element بناء على ال index و ال
+
+316
+00:25:22,160 --> 00:25:24,560
+size تبعتها لحظة انا ماتكلمتش على ال iterator لحد
+
+317
+00:25:24,560 --> 00:25:25,020
+اللحظة
+
+318
+00:25:28,470 --> 00:25:32,510
+ممكن اعتمد على ال 4H بداخل ال array list زي ما
+
+319
+00:25:32,510 --> 00:25:35,170
+كتبته قبل شوية مع ال array اللى موجودة عندى مافيش
+
+320
+00:25:35,170 --> 00:25:42,750
+مشكلة وممكن استفيد من ال iterator العرف iterator
+
+321
+00:25:42,750 --> 00:25:47,570
+object على string iterator object على string يساوي
+
+322
+00:25:47,570 --> 00:25:53,180
+color list dot iteratorwhile الـ iterator dot has
+
+323
+00:25:53,180 --> 00:25:57,680
+next مابهمنيش العدد جديش ولان مافيه element بدياهو
+
+324
+00:25:57,680 --> 00:26:01,320
+مانعيش كلهم system dot out dot print line
+
+325
+00:26:01,320 --> 00:26:04,660
+literator dot next عشان احصل على القيمة الموجودة
+
+326
+00:26:04,660 --> 00:26:08,340
+بالمناسبة لو احنا عملنا system dot out dot print
+
+327
+00:26:08,340 --> 00:26:15,940
+line او dot print ل ال colors فوق ايش ال output؟
+
+328
+00:26:15,940 --> 00:26:18,060
+هاي ال colors
+
+329
+00:26:21,520 --> 00:26:26,280
+أيوة بتديني ال reference address بتقولها طيب لو
+
+330
+00:26:26,280 --> 00:26:37,980
+أنا راح قلتله print ال color list نفس
+
+331
+00:26:37,980 --> 00:26:47,860
+الأشياء لأ هأضعلك الريب الشكل هذا red كما blue
+
+332
+00:26:47,860 --> 00:26:51,200
+green احنا حطيناه في البداية
+
+333
+00:26:54,640 --> 00:27:00,580
+green blue و white وهذا الفرق الأساسي بين ال array
+
+334
+00:27:00,580 --> 00:27:06,760
+و ال list لأنه في مجال أن أشوف ال data اللي موجودة
+
+335
+00:27:06,760 --> 00:27:10,720
+في الداخل ال list as one shot كأنها one element
+
+336
+00:27:10,720 --> 00:27:15,560
+أنا بأتعامل معاه طيب
+
+337
+00:27:15,560 --> 00:27:20,220
+في
+
+338
+00:27:20,220 --> 00:27:24,180
+طريقة تانية اللي حكيناها قبل شويةاللي هي arrays
+
+339
+00:27:24,180 --> 00:27:29,760
+.asList الـ arrays class في method aesthetic
+
+340
+00:27:29,760 --> 00:27:34,480
+method اسمها asList بترجع ب object من نوع list
+
+341
+00:27:34,480 --> 00:27:38,520
+وبالتالي أنا بقدر أستفيد منه أستفيد من ال array ..
+
+342
+00:27:38,520 --> 00:27:42,180
+من ال arrays.asList عشان أضيف ال element مرة واحدة
+
+343
+00:27:42,180 --> 00:27:44,980
+بدل ما أضيفهم element element من خلال .. أولا هقول
+
+344
+00:27:44,980 --> 00:27:49,820
+له ال list تبعتي بدأت ساوي arrays.asList colors
+
+345
+00:27:49,820 --> 00:27:55,620
+صارت في عندي listو أروح أستخدم ال list هذه as
+
+346
+00:27:55,620 --> 00:28:01,100
+argument لل constructor تبعت ال array list أو ممكن
+
+347
+00:28:01,100 --> 00:28:08,720
+بشكل مباشر أجيب ال line هذا بدون
+
+348
+00:28:08,720 --> 00:28:15,140
+ال semi colon طبعا و أجيبه مباشر أحطه مكان ال list
+
+349
+00:28:15,140 --> 00:28:17,840
+اللي عندي هان و بصير مباشر أخد كل عناصر ال array
+
+350
+00:28:17,840 --> 00:28:22,070
+بدون مضطر أكتب ال codeالطويل السابق اللي احنا
+
+351
+00:28:22,070 --> 00:28:26,790
+شوفناه قبل شوية هي
+
+352
+00:28:26,790 --> 00:28:31,990
+فعليا arrays as list عملت عاملة implementation
+
+353
+00:28:31,990 --> 00:28:34,590
+تماما لل code اللي احنا كتبناه قبل شوية عاملة
+
+354
+00:28:34,590 --> 00:28:38,170
+iterator او عاملة loop على عناصر ال array واضفتهم
+
+355
+00:28:38,170 --> 00:28:40,670
+بالترتيب السابق اللي احنا شوفناه
+
+356
+00:28:46,180 --> 00:28:49,540
+شوفنا الـ ArrayList وشوفنا الـ methods add و get و
+
+357
+00:28:49,540 --> 00:28:54,420
+contains و iterator مجموعة الـ method بما أن هذه
+
+358
+00:28:54,420 --> 00:28:59,240
+عاملة implementation ل ال collection class وفي
+
+359
+00:28:59,240 --> 00:29:02,980
+قلنا ال collections عاملة implementation ل ال
+
+360
+00:29:02,980 --> 00:29:06,460
+collection interface ال collection interface وقلنا
+
+361
+00:29:06,460 --> 00:29:10,360
+في عنا collection class collections class عامل
+
+362
+00:29:10,360 --> 00:29:13,730
+implementation ل الالـ interface اللي موجود عندى
+
+363
+00:29:13,730 --> 00:29:16,610
+وفيه عندى مجموعة من الـ static methods اللي ممكن
+
+364
+00:29:16,610 --> 00:29:23,510
+أنا أستفيد منها sort
+
+365
+00:29:23,510 --> 00:29:32,010
+يعني الأن هقول ال collections dot
+
+366
+00:29:32,010 --> 00:29:40,490
+sort عشان نكون واضحين من البداية لوالـ code أو
+
+367
+00:29:40,490 --> 00:29:46,170
+السؤال اللي جاكي كان بيقولك صحح الخطأ و كنت كاتب
+
+368
+00:29:46,170 --> 00:29:50,510
+لك collection تمام؟
+
+369
+00:29:50,510 --> 00:29:54,450
+انت مسئول اتحدد الخطأ هذا تمام؟ لكن لو قلت في
+
+370
+00:29:54,450 --> 00:29:57,790
+أثناء الامتحان قلت لك اكتبي code عشان تعملي صورة
+
+371
+00:29:57,790 --> 00:30:03,680
+القرية لو كتبت و نسيت ال Sأنا ممكن إيش؟ أمشيها
+
+372
+00:30:03,680 --> 00:30:08,100
+لأنه بفترض و للأسف هذا اللي بيصير أن معظمنا بيعتمد
+
+373
+00:30:08,100 --> 00:30:13,780
+على ال compiler يحددله الأخطاء فانت بدك تنتبه إذا
+
+374
+00:30:13,780 --> 00:30:18,000
+كان السؤال بيقول حدد الخطأمعناته بيتنتبهي للأسس
+
+375
+00:30:18,000 --> 00:30:21,920
+هذه مش تقولي والله الدكتور مابرحمش لاحقا لأ حسب
+
+376
+00:30:21,920 --> 00:30:25,000
+السؤال بيتتعاملي معاه لكن بوعدك إذا كانت السؤال
+
+377
+00:30:25,000 --> 00:30:28,300
+كتابة code و ال code اللي فيه طويل و محتاج يعني
+
+378
+00:30:28,300 --> 00:30:31,320
+تركيز عالي ممكن أسامح هنا في بعض الأخطاء اللي
+
+379
+00:30:31,320 --> 00:30:35,480
+املاقية أثناء الكتابة طيب collections قولنا that
+
+380
+00:30:35,480 --> 00:30:40,940
+sort إيش بتساوي تعمل ترتيب للعناصر ترتيب بناء على
+
+381
+00:30:40,940 --> 00:30:46,930
+إيش؟مباشرة مايخطرش على بالك إلا غير ترتيب Alpha
+
+382
+00:30:46,930 --> 00:30:51,410
+Numeric فقط إذا كل ال data اللي موجودة عند ال
+
+383
+00:30:51,410 --> 00:30:54,230
+string معناته بتتكلم على alphabetical ordering طب
+
+384
+00:30:54,230 --> 00:30:58,250
+تصعدي ولا تنازلي؟ لأ تصعدي، ترتيب by default
+
+385
+00:30:58,250 --> 00:31:04,590
+تصعدي، طب بتعمل ترتيب تنازلي؟ مافيشش، آه ال
+
+386
+00:31:04,590 --> 00:31:09,270
+reverse هي يا أستاذ اللي شدت نظرك هي بتعمل reverse
+
+387
+00:31:09,270 --> 00:31:13,040
+لل element يعني القارية تبعتي مثلا، فيها redو فيها
+
+388
+00:31:13,040 --> 00:31:17,720
+green و فيها blue إذا أنا قلتله reverse هتصير blue
+
+389
+00:31:17,720 --> 00:31:24,080
+green و red أنا بدي descending order sorting
+
+390
+00:31:24,080 --> 00:31:28,840
+descending sorting إيش بدي أساوي؟ بدي أروح أقوله
+
+391
+00:31:28,840 --> 00:31:33,480
+في الأول sort هيرتبلي إياها ترتيب تصعدي بعد هيك
+
+392
+00:31:33,480 --> 00:31:37,320
+إيش راح أقوله؟ أقول له أعملها reverse بروح بنعملي
+
+393
+00:31:37,320 --> 00:31:41,040
+إياها تنازلي فانا محتاج تجري ل two methods بالشكل
+
+394
+00:31:41,040 --> 00:31:47,280
+هذاbinary search مرت عليكي في ال data structure ان
+
+395
+00:31:47,280 --> 00:31:50,600
+ال array list هذه العناصر فيها مرتبة ترتيب sorted
+
+396
+00:31:50,600 --> 00:31:56,340
+ترتيب تصعدي وعملية ال search بتعتمد على halving ان
+
+397
+00:31:56,340 --> 00:32:00,240
+اجسم دائما ال list لرصين عشان اعمل skip لواحد من
+
+398
+00:32:00,240 --> 00:32:03,800
+ال half اللي موجودين عندى جولنا ال reverse ان انا
+
+399
+00:32:03,800 --> 00:32:05,920
+اروح اعمل reverse to the element of the list
+
+400
+00:32:05,920 --> 00:32:11,880
+shuffleترتيب عشوائي اعيد ترتيب العناصر ترتيب
+
+401
+00:32:11,880 --> 00:32:17,260
+عشوائي fill اعبّ القراية طبعا كمان مرة collections
+
+402
+00:32:17,260 --> 00:32:21,860
+dot
+
+403
+00:32:21,860 --> 00:32:28,180
+fill هذه هتاخد مني two objects او تاخد مني two
+
+404
+00:32:28,180 --> 00:32:34,070
+objects الأول اللي هي ال list تبعتنا والتانيالـ
+
+405
+00:32:34,070 --> 00:32:37,530
+object اللي أنا بدي أقعد بيه أضيفه تخيلي مثلا
+
+406
+00:32:37,530 --> 00:32:45,510
+white أو بلاش black عارفة
+
+407
+00:32:45,510 --> 00:32:48,990
+إيش هتصير في ال list اللي عندي هان؟ كل العناصر
+
+408
+00:32:48,990 --> 00:32:53,770
+اللي فيها هتصير black جداش هتضيف كام element؟ طب
+
+409
+00:32:53,770 --> 00:33:01,030
+لو كانت ال list فاضية مش هيعمل حاجةمش هيقدر يعبيها
+
+410
+00:33:01,030 --> 00:33:04,530
+ليش لأنه فعليا هو أنا جاعة بقوله fill فعشان ي fill
+
+411
+00:33:04,530 --> 00:33:07,570
+لازم يعمل list plus يكون already exist من خلال ال
+
+412
+00:33:07,570 --> 00:33:13,650
+add method اللي موجود عندها copy بنسخ
+
+413
+00:33:13,650 --> 00:33:18,190
+reference من list ل element ل list تانية minimum و
+
+414
+00:33:18,190 --> 00:33:23,910
+maximum معروفات add all يجيب كل العناصر اللي في
+
+415
+00:33:23,910 --> 00:33:29,020
+listويعملهم append لل list الموجودة عندي frequency
+
+416
+00:33:29,020 --> 00:33:34,800
+عشان يرجع ب number انتجة كم مرة ال element هذا
+
+417
+00:33:34,800 --> 00:33:39,760
+موجود في ال list كم مرة ال element هذا موجود في ال
+
+418
+00:33:39,760 --> 00:33:43,600
+list ولو كان في عندي two lists وبدأ أسأل هل في
+
+419
+00:33:43,600 --> 00:33:46,920
+بينهم تقاطع أو لأ؟ في عناصر مشتركة بينهم أو لأ؟
+
+420
+00:33:46,920 --> 00:33:53,420
+ممكن ألجأ للمتد اسمها disjoint بدي تنتبه أنه دائما
+
+421
+00:33:54,990 --> 00:34:00,490
+هذه الـ methods مابتعملش return مابتعملش return
+
+422
+00:34:00,490 --> 00:34:04,230
+مابتعملش
+
+423
+00:34:04,230 --> 00:34:11,610
+return مابتعملش return مابتعملش return مابتعملش
+
+424
+00:34:11,610 --> 00:34:12,010
+return مابتعملش return مابتعملش return مابتعملش
+
+425
+00:34:12,010 --> 00:34:12,230
+return مابتعملش return مابتعملش return مابتعملش
+
+426
+00:34:12,230 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+427
+00:34:12,250 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+428
+00:34:12,250 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+429
+00:34:12,250 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+430
+00:34:12,250 --> 00:34:12,250
+return مابتعملش return مابتعملش return مابتعملش
+
+431
+00:34:12,250 --> 00:34:12,390
+return مابتعملش return مابتعملش return مابتعملش
+
+432
+00:34:12,390 --> 00:34:19,750
+return مابتعملش return
+
+433
+00:34:19,750 --> 00:34:24,490
+مابأنا هيك بقوله collections.sort و بتديه الـ
+
+434
+00:34:24,490 --> 00:34:28,390
+killer list التقييم مباشرة الالمتحدث ان عمل ترتيب
+
+435
+00:34:28,390 --> 00:34:33,470
+لمين للعناصر في داخل الـ array يعني انت لو طبعتها
+
+436
+00:34:33,470 --> 00:34:40,130
+جبل و طبعتها بعد تمام مباشرة هتلاقيها جبل جبل عملت
+
+437
+00:34:40,130 --> 00:34:43,290
+ال sort كانت غير مرتبة و بعد ال sort تم ترتيبها
+
+438
+00:34:43,290 --> 00:34:44,310
+ترتيب تصعدي
+
+439
+00:34:51,250 --> 00:34:55,850
+الـ set ال
+
+440
+00:34:55,850 --> 00:35:00,750
+class التاني بتفرج عن ال array list على أنها
+
+441
+00:35:00,750 --> 00:35:09,190
+unordered collection of unique elements، unordered
+
+442
+00:35:09,190 --> 00:35:16,020
+طيب، بدياك تنتبه لكلمة ordered و unorderedغاد
+
+443
+00:35:16,020 --> 00:35:19,600
+قولنا ال order يعني الآن تخيل ال list ال first
+
+444
+00:35:19,600 --> 00:35:26,300
+position ال second ال third ال fourth إلى آخره
+
+445
+00:35:26,300 --> 00:35:31,460
+هدولة بالنسبالك معروفات بناء على إيش؟ بناء على ال
+
+446
+00:35:31,460 --> 00:35:35,660
+add بناء على ال push اللي صوتيها للعناصر اللي
+
+447
+00:35:35,660 --> 00:35:40,380
+موجودة عندها وعشان هات قولت ordered بينما .. بينما
+
+448
+00:35:40,380 --> 00:35:47,750
+لو كانت عندي set وروحت قولت لل set.add وقلت له red
+
+449
+00:35:47,750 --> 00:35:54,990
+object ووراها green ووراها blue مش ضروري يطلع ليهم
+
+450
+00:35:54,990 --> 00:36:00,250
+نفس الترتيب عشان إيه قلت عنها unordered لو أنا
+
+451
+00:36:00,250 --> 00:36:07,350
+أضفت ال read كمان مرة مش هيقبله مدنيش syntax error
+
+452
+00:36:07,350 --> 00:36:12,130
+هو بياخد ال object و بروح بده يعمله add إذا هو
+
+453
+00:36:12,130 --> 00:36:17,520
+existخلاص موجود does not exist بيضيفه على عناصر ال
+
+454
+00:36:17,520 --> 00:36:20,600
+array اللي موجودة عندها ال implementation تبعت ال
+
+455
+00:36:20,600 --> 00:36:26,780
+set ها اما من ال hash set او tree set اما hash set
+
+456
+00:36:26,780 --> 00:36:33,120
+او tree set ايش الفرق بينهم؟ ايش ال hashing؟
+
+457
+00:36:33,120 --> 00:36:35,680
+معناته ال hashing هي عبارة عن schema او algorithm
+
+458
+00:36:35,680 --> 00:36:41,980
+تمام الفكرة فيه انه يعمل place لل items يضيفهم
+
+459
+00:36:42,740 --> 00:36:51,000
+اضيفهم وين على index بتتم تحديده من ال element
+
+460
+00:36:51,000 --> 00:36:54,580
+نفسه يعني لو مانا في الدياجي أقولك أنا عندي مجموعة
+
+461
+00:36:54,580 --> 00:37:06,220
+من الأسماء أحمد و خالد و .. بس لحظة شوية اه مش
+
+462
+00:37:06,220 --> 00:37:11,960
+collection في الآخر بس اصبر شوية اه اصبر اصبر بهاء
+
+463
+00:37:13,740 --> 00:37:22,500
+و رائد مثلا و أضفت هدول لست أضفت هدول لست بناء على
+
+464
+00:37:22,500 --> 00:37:29,100
+hash function تمام تحدد ال position بناء على عدد
+
+465
+00:37:29,100 --> 00:37:36,400
+ال characters بناء على عدد ال characters بهاء خمسة
+
+466
+00:37:36,400 --> 00:37:41,560
+أحمد أو خالد ستة أحمد خمسة رائد أربعة يعني انه
+
+467
+00:37:41,560 --> 00:37:42,300
+رائد في الأول
+
+468
+00:37:46,340 --> 00:37:52,320
+الان بهاء و أحمد نفس الأشياء الأولوية اللي ظهر في
+
+469
+00:37:52,320 --> 00:37:57,440
+الأول و
+
+470
+00:37:57,440 --> 00:38:03,540
+بعدين بتجيبلي خالد هذا بناء على إيش؟ بناء على الـ
+
+471
+00:38:03,540 --> 00:38:06,820
+string length لكن ممكن تكون ال hash code مبنية
+
+472
+00:38:06,820 --> 00:38:11,760
+بناء alphabetical هتروح تحقق ليه بهاء أو أحمد بهاء
+
+473
+00:38:11,760 --> 00:38:16,260
+خالدرائد، حسب إيش الـ hash core الـ function تبعتي
+
+474
+00:38:16,260 --> 00:38:19,460
+اللي موجودة، ممكن يكون في عندي hash function تانية
+
+475
+00:38:19,460 --> 00:38:22,860
+تبني بناءً على ال summation تبعتي ال binary value
+
+476
+00:38:22,860 --> 00:38:27,580
+لكل character، تمام؟ فحسب إيش ال hashing اللي أنا
+
+477
+00:38:27,580 --> 00:38:31,700
+بتقدر، في الآخر بتعمل generate لمين؟ لل index،
+
+478
+00:38:31,700 --> 00:38:34,960
+عشان أحدد ال position تبعتي، الآن، هل ال index
+
+479
+00:38:34,960 --> 00:38:39,980
+اللي تم إنشاه وأنا بقدر استفيد منه؟ لأالـ Index
+
+480
+00:38:39,980 --> 00:38:44,920
+موجود نعم لكنه من خلال الـ hash code تمام؟ ففيش
+
+481
+00:38:44,920 --> 00:38:48,820
+مجال أروح أستخدم صفر و واحد و اتنين اللي أنا
+
+482
+00:38:48,820 --> 00:38:54,340
+بعرفهم لأ لأ لأ هذا مع ال order لأن ال locationهو
+
+483
+00:38:54,340 --> 00:38:58,260
+اللي له الـ index تمام؟ بينما ال location هذا تم
+
+484
+00:38:58,260 --> 00:39:01,760
+تحديده أو تم تحديد ال address .. ال index بتاعته
+
+485
+00:39:01,760 --> 00:39:04,180
+بناءًا على مين؟ بناءًا على ال hash function اللي
+
+486
+00:39:04,180 --> 00:39:07,440
+موجود ده عندي وبالتالي بقدرش .. أنا مش عارف إيش ال
+
+487
+00:39:07,440 --> 00:39:10,220
+output تبعت ال hash function عشان أقدر أعتمد على
+
+488
+00:39:10,220 --> 00:39:15,260
+مين؟ على ال index اللي عندي فال index موجود، هل
+
+489
+00:39:15,260 --> 00:39:20,640
+أستفيد منه؟ طيب، الآن .. وبالتالي أنا فيه عندي
+
+490
+00:39:20,640 --> 00:39:26,150
+hashingفي عندي hash code ال hash code في ال system
+
+491
+00:39:26,150 --> 00:39:31,030
+عندي هي عبارة عن integer value تم حسابتها بناء على
+
+492
+00:39:31,030 --> 00:39:34,970
+ال object اللي هم زي ما قلنا قبل شوية و المفروض ان
+
+493
+00:39:34,970 --> 00:39:39,350
+ال different object تديني different hash code عشان
+
+494
+00:39:39,350 --> 00:39:42,090
+مايصيرش في عندي duplication و في عندي .. يصير في
+
+495
+00:39:42,090 --> 00:39:45,290
+عندي two elements في نفس ال .. نفس الم .. نفس ال
+
+496
+00:39:45,290 --> 00:39:48,610
+location او نفس ال place لان أحيانا بصير في عندي
+
+497
+00:39:48,610 --> 00:39:54,050
+collision لما بكون في عندي different objectوطلع
+
+498
+00:39:54,050 --> 00:39:57,310
+لهم نفس الـ hash code يعني .. أجي أقول .. زي ما
+
+499
+00:39:57,310 --> 00:40:03,470
+قلنا قبل شوية عندي أحمد و بهق تمام؟ لو كنت باعتمد
+
+500
+00:40:03,470 --> 00:40:08,550
+على عدد ال characters التنب طلع لهم خمسة أصبت؟ طب
+
+501
+00:40:08,550 --> 00:40:10,850
+معناه أن التنب دول بيكونوا في نفس ال position هانا
+
+502
+00:40:10,850 --> 00:40:13,350
+حابب أسميه إيه اللي صار في عندي؟ collision بحيث أن
+
+503
+00:40:13,350 --> 00:40:18,130
+ال two different objects طلع لهم same hash code
+
+504
+00:40:18,130 --> 00:40:23,700
+طبعا المفروض أن ال hash function الجيدةالـ hash
+
+505
+00:40:23,700 --> 00:40:27,440
+function الجيدة دائماً عدد الـ collection فيها
+
+506
+00:40:27,440 --> 00:40:33,000
+منخفض جداً من الأمثلة الفعالة جداً في موضوع الـ
+
+507
+00:40:33,000 --> 00:40:37,960
+hash code اللي بناخد عليها رقم الهوية أو الرقم
+
+508
+00:40:37,960 --> 00:40:42,760
+الوطني هو كيف بنعملها validation وهذه الشيء التاني
+
+509
+00:40:42,760 --> 00:40:46,460
+في الـ hash code المفروض إن الـ hash code هذا أقدر
+
+510
+00:40:46,460 --> 00:40:50,900
+من خلاله أصل ال data الحقيقية لما أعمل reverse
+
+511
+00:40:51,870 --> 00:40:55,850
+Engineering للـ code اللي موجود عندى anyway ففي
+
+512
+00:40:55,850 --> 00:41:00,010
+الآخر هذا هو ال hash code في عندى ال hash table هو
+
+513
+00:41:00,010 --> 00:41:05,450
+ال position او هو الجدول اللى بيبنى على مين على ال
+
+514
+00:41:05,450 --> 00:41:09,890
+hash code و ال index تبعته بتكون هي عبارة عن ال
+
+515
+00:41:09,890 --> 00:41:13,850
+hash code اللى موجود عندى عشان اضيفه طبعا في عندى
+
+516
+00:41:13,850 --> 00:41:18,950
+ال load factor جدش في عندى data موجودة وجدش في
+
+517
+00:41:18,950 --> 00:41:24,990
+عندى ال ratio بينعدد الخلايا الموجودة في الـ hash
+
+518
+00:41:24,990 --> 00:41:31,070
+table وعدد الخلايا المستخدمة من الجدول على عدد
+
+519
+00:41:31,070 --> 00:41:34,930
+الخلايا الكلي بنسميها ال load factor وليس قضية
+
+520
+00:41:34,930 --> 00:41:37,870
+كتير هيديلها علاقة بال performance كده ال hash
+
+521
+00:41:37,870 --> 00:41:41,790
+code تبعتي بتعمل generate صح أو allocation صح
+
+522
+00:41:41,790 --> 00:41:45,610
+للعناصر anyway تعالى نشوف بال Java بال code تبعنا
+
+523
+00:41:46,560 --> 00:41:49,420
+array list أو a b c array عبارة عن array of string
+
+524
+00:41:49,420 --> 00:41:51,740
+فيها مجموعة من ال characters ال b و ال c
+
+525
+00:41:51,740 --> 00:41:56,200
+duplicated values أنا روحت عرفت array list في
+
+526
+00:41:56,200 --> 00:42:00,640
+البداية اللي حشوفناها في الكود السابق و أضفت ال
+
+527
+00:42:00,640 --> 00:42:05,100
+array تبعتيها لل array list و روحت طبعتها مباشرة
+
+528
+00:42:05,100 --> 00:42:11,020
+هيطبعلي ال array list مثل ما أضفتها تماما ordered
+
+529
+00:42:11,020 --> 00:42:13,920
+و تسمح بال duplication هي ال list
+
+530
+00:42:17,800 --> 00:42:25,080
+عملت set هاش set وأضفت لها ال array list تبعتي أو
+
+531
+00:42:25,080 --> 00:42:27,500
+ال array عفوا اللي عندي أو ال array list فاش مشكلة
+
+532
+00:42:27,500 --> 00:42:34,980
+عندي وروحت طبعتها مباشرة إيش تتوقعي؟ أول حاجة مش
+
+533
+00:42:34,980 --> 00:42:39,830
+هيكون في duplication الشغل التاني الترتيبالترتيب
+
+534
+00:42:39,830 --> 00:42:42,450
+حسب الـ hash function حسب الـ hash function
+
+535
+00:42:42,450 --> 00:42:45,770
+المعتمدة الجافة في ال output اللي عندي فاطلع لي a
+
+536
+00:42:45,770 --> 00:42:50,370
+b c d e هيك أنا بفهم ان ال hash function اعتمدت
+
+537
+00:42:50,370 --> 00:42:56,310
+على ال alphabetical او alphabetical schema لترتيب
+
+538
+00:42:56,310 --> 00:43:00,930
+ال data اللي موجود عندها بقى عندي اخر شغلة خلال
+
+539
+00:43:00,930 --> 00:43:03,630
+دقيقة ان شاء الله بنخلصها و لو اضطرنا بنرجع لها
+
+540
+00:43:03,630 --> 00:43:09,100
+مرة تانية الآن بما انهبشكل أو باخر بدي أعمل
+
+541
+00:43:09,100 --> 00:43:11,880
+implementation للـ tree أو للـ set اللي موجودة
+
+542
+00:43:11,880 --> 00:43:16,060
+عندي هان قولنا احنا اما ب hash code او hash
+
+543
+00:43:16,060 --> 00:43:20,460
+function او hash set او tree set ايش مفهوم الـ
+
+544
+00:43:20,460 --> 00:43:23,800
+tree؟ انا بتكلم على مجموعة من الباخذ و لا لأ من
+
+545
+00:43:23,800 --> 00:43:28,960
+المسارات فالـ tree هي لازم تكون sorted مفهوم الـ
+
+546
+00:43:28,960 --> 00:43:33,060
+tree دائما إذا أنا بتكلم على ال roadالـ value اللي
+
+547
+00:43:33,060 --> 00:43:37,360
+على اليسار أقل والـ value اللي على اليمين أكبر
+
+548
+00:43:37,360 --> 00:43:41,160
+سواء كنت بتكلم على binary tree أو غيرها ففي الآخر
+
+549
+00:43:41,160 --> 00:43:50,040
+هتكون في عندي sorted وفعليا حتى ال hash ممكن أحصل
+
+550
+00:43:50,040 --> 00:43:52,740
+على sorted حسب ال scheme ال hash code ال hash
+
+551
+00:43:52,740 --> 00:43:56,580
+function اللي موجودة عندها طيب إذا كانت ال data
+
+552
+00:43:56,580 --> 00:44:01,070
+sortedفي الـ Tree اللي عندي معناته أنا بقدر ..
+
+553
+00:44:01,070 --> 00:44:04,810
+طبعا إذا كنت استخدمت الـ Tree set object عشان أنشئ
+
+554
+00:44:04,810 --> 00:44:08,770
+ال set تبعتي في عندي شغل اسمها ال head set و ال
+
+555
+00:44:08,770 --> 00:44:13,590
+tail set بالإضافة لل first و ال last ال method
+
+556
+00:44:13,590 --> 00:44:18,790
+الأولى ال head set بترجع ب subset تمام اللي موجودة
+
+557
+00:44:18,790 --> 00:44:24,730
+قبل يعني تخيلي A,B,C,D,E هاي العناصر اللي موجودة
+
+558
+00:44:24,730 --> 00:44:29,400
+عندي هنا و ال F يكنو جيت و قلت لك بدي الـ sub أو
+
+559
+00:44:29,400 --> 00:44:33,220
+الـ tail set لل set اللي موجود هذا بناء على ال D
+
+560
+00:44:33,220 --> 00:44:42,500
+هذه ال function هذه ABC بمثله head set المجموع
+
+561
+00:44:42,500 --> 00:44:46,860
+اللي هي sub set المجموع القبل وال tail set من ال D
+
+562
+00:44:46,860 --> 00:44:52,630
+للآخربتحتوى الـ D طب و ال first و ال last ال first
+
+563
+00:44:52,630 --> 00:44:55,130
+element و ال last element اللي موجودين على ال tree
+
+564
+00:44:55,130 --> 00:44:57,630
+تعالى نشوف ال code هذا على السريع المحاضرة الجاية
+
+565
+00:44:57,630 --> 00:45:01,670
+ان شاء الله تعالى لأن الوقت أدركنا بنبدأ من عند ال
+
+566
+00:45:01,670 --> 00:45:04,310
+sets و بنتكلم على ال tree set ان شاء الله تبارك
+
+567
+00:45:04,310 --> 00:45:07,910
+وتعالى تي اي سؤال يا بنات؟ بيبقى سهل ال tree set
+
+568
+00:45:07,910 --> 00:45:10,250
+انا بحدد من وين و من كده بناء على ال character
+
+569
+00:45:10,250 --> 00:45:12,970
+اللي بتحدي دي نعم الله تكل عافية
+
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/vTdi76wdbPg_raw.json b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/vTdi76wdbPg_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..242435a286348e20b66dfbb93f935cd476691a1a
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/vTdi76wdbPg_raw.json
@@ -0,0 +1 @@
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{"start": 191.57, "end": 191.93, "word": " قلنا", "probability": 0.7874348958333334}, {"start": 191.93, "end": 192.59, "word": " set", "probability": 0.97900390625}, {"start": 192.59, "end": 193.09, "word": " editable", "probability": 0.8759765625}, {"start": 193.09, "end": 193.39, "word": " عشان", "probability": 0.9842122395833334}, {"start": 193.39, "end": 193.69, "word": " أمكن", "probability": 0.87060546875}, {"start": 193.69, "end": 193.87, "word": " ال", "probability": 0.89599609375}, {"start": 193.87, "end": 194.15, "word": " user", "probability": 0.9423828125}, {"start": 194.15, "end": 194.67, "word": " يكتب", "probability": 0.9864501953125}, {"start": 194.67, "end": 194.77, "word": " في", "probability": 0.93994140625}, {"start": 194.77, "end": 195.27, "word": " داخلها", "probability": 0.98974609375}, {"start": 195.27, "end": 196.27, "word": " باستعمالها", "probability": 0.8960774739583334}, {"start": 196.27, "end": 196.37, "word": " زي", "probability": 0.9072265625}, {"start": 196.37, "end": 196.45, "word": " ال", "probability": 0.7099609375}, {"start": 196.45, "end": 196.63, "word": " text", "probability": 0.97509765625}, {"start": 196.63, "end": 196.93, "word": " field", "probability": 0.91943359375}], "temperature": 1.0}, {"id": 9, "seek": 21863, "start": 197.97, "end": 218.63, "text": "والعناصر اللي أنا بدي أظهرهم في ال list بدي أضيفهم من خلال ال method إما add items اللي هي بتعمل دائما a bind لل list يعني الأخر عنصر أنا بضيفه بيديوين في نهاية القائمة أو لو أنا بدي أتحكم بال index وترتيب العناصر بصير بقوله insert item at في مقابل insert item at في عندي remove", "tokens": [2407, 6027, 3615, 8315, 9381, 2288, 13672, 1829, 41850, 4724, 16254, 5551, 19913, 3224, 2288, 16095, 8978, 2423, 1329, 4724, 16254, 5551, 11242, 33911, 16095, 9154, 16490, 1211, 6027, 2423, 3170, 11933, 15042, 909, 4754, 13672, 1829, 39896, 39894, 25957, 1211, 11778, 16373, 15042, 257, 14786, 24976, 1329, 37495, 22653, 16247, 34740, 18871, 9381, 2288, 41850, 4724, 11242, 33911, 3224, 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208.85, "word": " في", "probability": 0.87841796875}, {"start": 208.85, "end": 209.13, "word": " نهاية", "probability": 0.98291015625}, {"start": 209.13, "end": 209.63, "word": " القائمة", "probability": 0.99072265625}, {"start": 209.63, "end": 210.55, "word": " أو", "probability": 0.8388671875}, {"start": 210.55, "end": 210.69, "word": " لو", "probability": 0.98193359375}, {"start": 210.69, "end": 210.81, "word": " أنا", "probability": 0.88623046875}, {"start": 210.81, "end": 210.95, "word": " بدي", "probability": 0.75927734375}, {"start": 210.95, "end": 211.35, "word": " أتحكم", "probability": 0.9305419921875}, {"start": 211.35, "end": 211.53, "word": " بال", "probability": 0.9697265625}, {"start": 211.53, "end": 211.85, "word": " index", "probability": 0.8857421875}, {"start": 211.85, "end": 212.31, "word": " وترتيب", "probability": 0.8570556640625}, {"start": 212.31, "end": 212.89, "word": " العناصر", "probability": 0.8836669921875}, {"start": 212.89, "end": 213.49, "word": " بصير", "probability": 0.9606119791666666}, {"start": 213.49, "end": 213.79, "word": " بقوله", "probability": 0.6993001302083334}, {"start": 213.79, "end": 214.21, "word": " insert", "probability": 0.90966796875}, {"start": 214.21, "end": 215.05, "word": " item", "probability": 0.9482421875}, {"start": 215.05, "end": 215.73, "word": " at", "probability": 0.908203125}, {"start": 215.73, "end": 216.27, "word": " في", "probability": 0.65185546875}, {"start": 216.27, "end": 216.73, "word": " مقابل", "probability": 0.860107421875}, {"start": 216.73, "end": 217.09, "word": " insert", "probability": 0.6669921875}, {"start": 217.09, "end": 217.53, "word": " item", "probability": 0.96240234375}, {"start": 217.53, "end": 217.79, "word": " at", "probability": 0.9833984375}, {"start": 217.79, "end": 217.95, "word": " في", "probability": 0.669921875}, {"start": 217.95, "end": 218.21, "word": " عندي", "probability": 0.75146484375}, {"start": 218.21, "end": 218.63, "word": " remove", "probability": 0.95458984375}], "temperature": 1.0}, {"id": 10, "seek": 22808, "start": 219.8, "end": 228.08, "text": "item at وفي عند remove الأولى بتاخد ال index والتانية بتاخد ال object أو ال element اللي أنا بدي أحلفه", "tokens": [270, 443, 412, 4032, 41185, 43242, 4159, 16247, 12610, 7578, 39894, 47283, 3215, 2423, 8186, 16070, 2655, 7649, 10632, 39894, 47283, 3215, 2423, 2657, 34051, 2423, 4478, 13672, 1829, 41850, 4724, 16254, 5551, 5016, 46538, 3224], "avg_logprob": -0.2396537226599616, "compression_ratio": 1.3135593220338984, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 219.8, "end": 220.34, "word": "item", "probability": 0.840087890625}, {"start": 220.34, "end": 220.68, "word": " at", "probability": 0.4892578125}, {"start": 220.68, "end": 221.28, "word": " وفي", "probability": 0.27081298828125}, {"start": 221.28, "end": 221.48, "word": " عند", "probability": 0.93505859375}, {"start": 221.48, "end": 221.96, "word": " remove", "probability": 0.56298828125}, {"start": 221.96, "end": 222.84, "word": " الأولى", "probability": 0.81982421875}, {"start": 222.84, "end": 223.18, "word": " بتاخد", "probability": 0.9052734375}, {"start": 223.18, "end": 223.28, "word": " ال", "probability": 0.89453125}, {"start": 223.28, "end": 223.68, "word": " index", "probability": 0.8544921875}, {"start": 223.68, "end": 224.5, "word": " والتانية", "probability": 0.8807373046875}, {"start": 224.5, "end": 225.06, "word": " بتاخد", "probability": 0.98193359375}, {"start": 225.06, "end": 225.6, "word": " ال", "probability": 0.93701171875}, {"start": 225.6, "end": 225.96, "word": " object", "probability": 0.95458984375}, {"start": 225.96, "end": 226.16, "word": " أو", "probability": 0.81005859375}, {"start": 226.16, "end": 226.26, "word": " ال", "probability": 0.9609375}, {"start": 226.26, "end": 226.52, "word": " element", "probability": 0.9658203125}, {"start": 226.52, "end": 226.68, "word": " اللي", "probability": 0.82275390625}, {"start": 226.68, "end": 226.9, "word": " أنا", "probability": 0.428466796875}, {"start": 226.9, "end": 227.6, "word": " بدي", "probability": 0.6773681640625}, {"start": 227.6, "end": 228.08, "word": " أحلفه", "probability": 0.8896484375}], "temperature": 1.0}, {"id": 11, "seek": 25305, "start": 229.01, "end": 253.05, "text": "وفي عندى get selected item عشان ارجع بالعنصر اللى تم اختياره من ال combo box فى عندى method مهم جدا لأن في كتير من الأحيان في ال application أنا مضطر أظل أنسح العناصر اللى موجودة في ال combo box و أعبيها مرة تانية وضربنا المثال المرة الماضية في موضوع ال city أو الدولة أو عفوا ان المدينة تبقى الدولة لما بغير الدولة الاصل المدينة هذه بتتم مسحها و تتكتب", "tokens": [2407, 41185, 43242, 7578, 483, 8209, 3174, 6225, 8592, 7649, 1975, 47341, 3615, 20666, 3615, 1863, 9381, 2288, 13672, 7578, 46811, 1975, 9778, 31371, 9640, 3224, 9154, 2423, 16859, 2424, 6156, 7578, 43242, 7578, 3170, 3714, 16095, 10874, 28259, 5296, 33456, 8978, 9122, 2655, 13546, 9154, 16247, 5016, 1829, 7649, 8978, 2423, 3861, 41850, 3714, 11242, 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"probability": 0.7364501953125}, {"start": 234.57, "end": 234.81, "word": " عندى", "probability": 0.838623046875}, {"start": 234.81, "end": 235.05, "word": " method", "probability": 0.98681640625}, {"start": 235.05, "end": 235.37, "word": " مهم", "probability": 0.99072265625}, {"start": 235.37, "end": 235.83, "word": " جدا", "probability": 0.921630859375}, {"start": 235.83, "end": 236.41, "word": " لأن", "probability": 0.75927734375}, {"start": 236.41, "end": 236.51, "word": " في", "probability": 0.58544921875}, {"start": 236.51, "end": 236.71, "word": " كتير", "probability": 0.8126627604166666}, {"start": 236.71, "end": 236.83, "word": " من", "probability": 0.97802734375}, {"start": 236.83, "end": 237.21, "word": " الأحيان", "probability": 0.9417724609375}, {"start": 237.21, "end": 237.35, "word": " في", "probability": 0.79052734375}, {"start": 237.35, "end": 237.43, "word": " ال", "probability": 0.9638671875}, {"start": 237.43, "end": 237.89, "word": " application", "probability": 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"end": 242.13, "word": " أعبيها", "probability": 0.882080078125}, {"start": 242.13, "end": 242.41, "word": " مرة", "probability": 0.912109375}, {"start": 242.41, "end": 242.75, "word": " تانية", "probability": 0.9767252604166666}, {"start": 242.75, "end": 243.55, "word": " وضربنا", "probability": 0.9163818359375}, {"start": 243.55, "end": 243.87, "word": " المثال", "probability": 0.8741861979166666}, {"start": 243.87, "end": 244.15, "word": " المرة", "probability": 0.96533203125}, {"start": 244.15, "end": 244.67, "word": " الماضية", "probability": 0.9908854166666666}, {"start": 244.67, "end": 245.05, "word": " في", "probability": 0.81298828125}, {"start": 245.05, "end": 245.33, "word": " موضوع", "probability": 0.9949951171875}, {"start": 245.33, "end": 245.49, "word": " ال", "probability": 0.8759765625}, {"start": 245.49, "end": 245.75, "word": " city", "probability": 0.9658203125}, {"start": 245.75, "end": 246.11, "word": " أو", "probability": 0.72216796875}, {"start": 246.11, "end": 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"end": 251.83, "word": " هذه", "probability": 0.3056640625}, {"start": 251.83, "end": 252.19, "word": " بتتم", "probability": 0.5989990234375}, {"start": 252.19, "end": 252.53, "word": " مسحها", "probability": 0.6829427083333334}, {"start": 252.53, "end": 252.67, "word": " و", "probability": 0.409912109375}, {"start": 252.67, "end": 253.05, "word": " تتكتب", "probability": 0.831884765625}], "temperature": 1.0}, {"id": 12, "seek": 27800, "start": 253.88, "end": 278.0, "text": "من جديد في ال list وبالتالي انا محتاج ان ا remove all items عشان اعبيها مرة تانية بالمدن المناسبة للدولة حسب ال action اللي عندى وانتهينا من ال combo books وبدنا نبدأ اليوم مع ال slider بدنا نبدأ اليوم مع ال slider الآن في ال slider كل كو او غير لما ضمنا معانا smartphone", "tokens": [27842, 10874, 16254, 3215, 8978, 2423, 1329, 46599, 6027, 2655, 6027, 1829, 1975, 8315, 3714, 33753, 26108, 16472, 1975, 4159, 439, 4754, 6225, 8592, 7649, 1975, 3615, 21292, 11296, 3714, 25720, 6055, 7649, 10632, 20666, 2304, 3215, 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279.3, "end": 299.58, "text": "و ال slider هذا بنستخدمه باستمرار نستخدمه لما نتحكم بشدة الإضاءة و نتحكم فيه لما نتحدث أو لما نتحدث بشدة الصوت أو بالصوت وبالتالي هذا هو ال slider ال slider هو عبارة عن selector من خلال integer value من خلال integer value range بحدد ال range انت", "tokens": [2407, 2423, 26046, 23758, 44945, 14851, 9778, 40448, 3224, 4724, 995, 14851, 29973, 9640, 8717, 14851, 9778, 40448, 3224, 5296, 15042, 8717, 2655, 5016, 24793, 4724, 8592, 41891, 33688, 11242, 16606, 3660, 4032, 8717, 2655, 5016, 24793, 8978, 3224, 5296, 15042, 8717, 2655, 24401, 12984, 34051, 5296, 15042, 8717, 2655, 24401, 12984, 4724, 8592, 41891, 31767, 35473, 34051, 20666, 9381, 35473, 46599, 6027, 2655, 6027, 1829, 23758, 31439, 2423, 26046, 2423, 26046, 31439, 6225, 3555, 9640, 3660, 18871, 23264, 1672, 9154, 16490, 1211, 6027, 24922, 2158, 9154, 16490, 1211, 6027, 24922, 2158, 3613, 4724, 24401, 3215, 2423, 3613, 16472, 2655], "avg_logprob": -0.17435025460649245, "compression_ratio": 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في الصورة هذا label أنا أضافته أنا أضافته سابقا عشان بس أقول إيش القيمة اللي اللي عملها إيش selection معلنا ال constructor تبع ال slider بياخد مني تلت شغلات بياخد ال minimum value وبياخد ال maximum value وبياخد ال initial value by default لو أنا ماكتبتش الكلام هذا هتكون القيم اللي عندي صفر مية خمسين by default هتكون القيم اللي عندي هنا صفر", "tokens": [6027, 20292, 8978, 31767, 13063, 3660, 23758, 7645, 41850, 5551, 11242, 31845, 47395, 41850, 5551, 11242, 31845, 47395, 8608, 16758, 4587, 995, 6225, 8592, 7649, 4724, 3794, 5551, 39648, 11933, 1829, 8592, 25062, 32640, 3660, 13672, 1829, 13672, 1829, 6225, 42213, 11296, 11933, 1829, 8592, 9450, 20449, 1211, 8315, 2423, 47479, 6055, 3555, 3615, 2423, 26046, 4724, 1829, 47283, 3215, 9154, 1829, 6055, 1211, 2655, 13412, 17082, 1211, 9307, 4724, 1829, 47283, 3215, 2423, 7285, 2158, 4032, 21292, 47283, 3215, 2423, 6674, 2158, 4032, 21292, 47283, 3215, 2423, 5883, 2158, 538, 7576, 45164, 41850, 19446, 4117, 2655, 3555, 2655, 8592, 2423, 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Slider إذا كنت أنا متكلم على من 0 ل100 طيب هل أنا فعليا بدي ال Text هذي ولا بدي؟", "tokens": [6027, 39184, 18643, 8032, 47302, 39894, 19913, 3224, 2288, 2319, 18643, 44650, 3794, 995, 2407, 10632, 15844, 2423, 6187, 1438, 11933, 15730, 9122, 29399, 41850, 44650, 4117, 19528, 15844, 9154, 1958, 5296, 6879, 23032, 1829, 3555, 8032, 1211, 41850, 6156, 3615, 20292, 995, 4724, 16254, 2423, 18643, 8032, 8848, 1829, 49429, 4724, 16254, 22807], "avg_logprob": -0.31931819265538997, "compression_ratio": 1.3857142857142857, "no_speech_prob": 0.0, "words": [{"start": 521.03, "end": 521.31, "word": "الـ", "probability": 0.589599609375}, {"start": 521.31, "end": 521.49, "word": " Text", "probability": 0.434814453125}, {"start": 521.49, "end": 521.73, "word": " هاي", "probability": 0.5303955078125}, {"start": 521.73, "end": 522.65, "word": " بتظهر", "probability": 0.86749267578125}, {"start": 522.65, "end": 522.97, "word": " 100", "probability": 0.2440185546875}, {"start": 522.97, "end": 523.37, 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value", "probability": 0.990234375}, {"start": 1176.56, "end": 1176.92, "word": " zero", "probability": 0.274658203125}, {"start": 1176.92, "end": 1177.62, "word": " في", "probability": 0.6748046875}, {"start": 1177.62, "end": 1178.06, "word": " boundaries", "probability": 0.59814453125}, {"start": 1178.06, "end": 1178.42, "word": " في", "probability": 0.712890625}, {"start": 1178.42, "end": 1178.76, "word": " حدود", "probability": 0.9718424479166666}, {"start": 1178.76, "end": 1179.3, "word": " الأرقام", "probability": 0.946533203125}, {"start": 1179.3, "end": 1179.78, "word": " لأ", "probability": 0.673828125}], "temperature": 1.0}, {"id": 47, "seek": 120081, "start": 1182.13, "end": 1200.81, "text": "الـ model هذا التاني number model number limited بيبدأ من صفر لمية ال initial value خمسين ومقدار ال step عشرة بعد المية مافيش أرقام و تحت الصفر مافيش أرقام لما بتكلم على ال list list model", "tokens": [6027, 39184, 2316, 23758, 16712, 7649, 1829, 1230, 2316, 1230, 5567, 4724, 1829, 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"probability": 0.9930419921875}, {"start": 1248.97, "end": 1249.33, "word": " ما", "probability": 0.84619140625}, {"start": 1249.33, "end": 1249.47, "word": " بين", "probability": 0.970703125}, {"start": 1249.47, "end": 1249.91, "word": " التنتين", "probability": 0.6973470052083334}, {"start": 1249.91, "end": 1251.95, "word": " okay", "probability": 0.058990478515625}, {"start": 1251.95, "end": 1255.47, "word": " ال", "probability": 0.66796875}, {"start": 1255.47, "end": 1255.75, "word": " minimum", "probability": 0.6220703125}, {"start": 1255.75, "end": 1256.45, "word": " الصفر", "probability": 0.85791015625}, {"start": 1256.45, "end": 1256.69, "word": " هذه", "probability": 0.68310546875}, {"start": 1256.69, "end": 1257.25, "word": " بتمثل", "probability": 0.9505615234375}, {"start": 1257.25, "end": 1257.39, "word": " ال", "probability": 0.94482421875}, {"start": 1257.39, "end": 1257.75, "word": " minimum", "probability": 0.9853515625}, {"start": 1257.75, "end": 1259.85, "word": " value", "probability": 0.97509765625}], "temperature": 1.0}, {"id": 50, "seek": 126591, "start": 1260.51, "end": 1265.91, "text": "على الخط okay هاي صفر", "tokens": [3615, 23942, 33962, 9566, 1392, 8032, 47302, 20328, 5172, 2288], "avg_logprob": -0.4147727381099354, "compression_ratio": 0.7906976744186046, "no_speech_prob": 0.0, "words": [{"start": 1260.51, "end": 1260.91, "word": "على", "probability": 0.77001953125}, {"start": 1260.91, "end": 1261.37, "word": " الخط", "probability": 0.987060546875}, {"start": 1261.37, "end": 1262.25, "word": " okay", "probability": 0.09552001953125}, {"start": 1262.25, "end": 1265.55, "word": " هاي", "probability": 0.5072021484375}, {"start": 1265.55, "end": 1265.91, "word": " صفر", "probability": 0.9783528645833334}], "temperature": 1.0}, {"id": 51, "seek": 129469, "start": 1266.69, "end": 1294.69, "text": "أو okay هي مافيش صفر اللي احنا بدك spinner انت قلت على الخط اللي هتكون الان لما بفتح ال program بشغل برنامج تبعي اول ما بتظهر ال four بتظهر بالخمسين اللي هي ال initial value الان ايش ال minimum value لو انا ضليت انقص عشرة عشرة ايش ال minimum value تبعتي عند الصفر بعد الصفر مش هيرضى انقص ولا حاجة في ال list خلاص انتهت ال list تبعتي تمام بصير انا ممكن اشتغل بالاضافة", "tokens": [10721, 2407, 1392, 39896, 19446, 41185, 8592, 20328, 5172, 2288, 13672, 1829, 1975, 5016, 8315, 47525, 4117, 44849, 16472, 2655, 12174, 1211, 2655, 15844, 33962, 9566, 13672, 1829, 8032, 2655, 30544, 2423, 7649, 5296, 15042, 4724, 5172, 2655, 5016, 2423, 1461, 4724, 8592, 17082, 1211, 4724, 2288, 8315, 2304, 7435, 6055, 3555, 3615, 1829, 1975, 12610, 19446, 39894, 19913, 3224, 2288, 2423, 1451, 39894, 19913, 3224, 2288, 20666, 9778, 2304, 3794, 9957, 13672, 1829, 39896, 2423, 5883, 2158, 2423, 7649, 1975, 1829, 8592, 2423, 7285, 2158, 45164, 1975, 8315, 48812, 20292, 2655, 1975, 1863, 4587, 9381, 6225, 8592, 25720, 6225, 8592, 25720, 1975, 1829, 8592, 2423, 7285, 2158, 6055, 3555, 3615, 31371, 43242, 31767, 5172, 2288, 39182, 31767, 5172, 2288, 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"probability": 0.97021484375}, {"start": 1290.89, "end": 1291.33, "word": " تبعتي", "probability": 0.9752197265625}, {"start": 1291.33, "end": 1292.13, "word": " تمام", "probability": 0.760986328125}, {"start": 1292.13, "end": 1292.59, "word": " بصير", "probability": 0.806640625}, {"start": 1292.59, "end": 1292.71, "word": " انا", "probability": 0.924560546875}, {"start": 1292.71, "end": 1292.89, "word": " ممكن", "probability": 0.9892578125}, {"start": 1292.89, "end": 1294.07, "word": " اشتغل", "probability": 0.94765625}, {"start": 1294.07, "end": 1294.69, "word": " بالاضافة", "probability": 0.9666748046875}], "temperature": 1.0}, {"id": 52, "seek": 132055, "start": 1297.57, "end": 1320.55, "text": "ما تخرطيش بين ال slidder و بين ال spinner العنصر اللي بعده ال J list ال J list هي قائمة أقرب لل combo box لكنها قائمة غير منسدلة ظاهرة بس هل بظهر كل العناصر اللي فيها", "tokens": [15042, 6055, 9778, 2288, 9566, 1829, 8592, 49374, 2423, 1061, 327, 1068, 4032, 49374, 2423, 44849, 18863, 1863, 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"word": " بين", "probability": 0.814453125}, {"start": 1299.37, "end": 1300.13, "word": " ال", "probability": 0.9248046875}, {"start": 1300.13, "end": 1300.45, "word": " spinner", "probability": 0.8974609375}, {"start": 1300.45, "end": 1304.81, "word": " العنصر", "probability": 0.9669189453125}, {"start": 1304.81, "end": 1306.19, "word": " اللي", "probability": 0.846435546875}, {"start": 1306.19, "end": 1306.65, "word": " بعده", "probability": 0.93359375}, {"start": 1306.65, "end": 1307.97, "word": " ال", "probability": 0.67578125}, {"start": 1307.97, "end": 1308.13, "word": " J", "probability": 0.7255859375}, {"start": 1308.13, "end": 1308.47, "word": " list", "probability": 0.58935546875}, {"start": 1308.47, "end": 1310.49, "word": " ال", "probability": 0.61376953125}, {"start": 1310.49, "end": 1310.67, "word": " J", "probability": 0.93310546875}, {"start": 1310.67, "end": 1311.03, "word": " list", "probability": 0.94482421875}, {"start": 1311.03, "end": 1312.77, "word": " هي", "probability": 0.927734375}, {"start": 1312.77, "end": 1313.23, "word": " قائمة", "probability": 0.9803059895833334}, {"start": 1313.23, "end": 1314.31, "word": " أقرب", "probability": 0.87744140625}, {"start": 1314.31, "end": 1314.49, "word": " لل", "probability": 0.5615234375}, {"start": 1314.49, "end": 1314.81, "word": " combo", "probability": 0.76708984375}, {"start": 1314.81, "end": 1315.19, "word": " box", "probability": 0.92919921875}, {"start": 1315.19, "end": 1315.85, "word": " لكنها", "probability": 0.90673828125}, {"start": 1315.85, "end": 1316.09, "word": " قائمة", "probability": 0.9845377604166666}, {"start": 1316.09, "end": 1316.29, "word": " غير", "probability": 0.99609375}, {"start": 1316.29, "end": 1316.83, "word": " منسدلة", "probability": 0.68487548828125}, {"start": 1316.83, "end": 1318.71, "word": " ظاهرة", "probability": 0.80267333984375}, {"start": 1318.71, "end": 1319.11, "word": " بس", "probability": 0.663818359375}, {"start": 1319.11, "end": 1319.25, "word": " هل", "probability": 0.892333984375}, {"start": 1319.25, "end": 1319.53, "word": " بظهر", "probability": 0.8282470703125}, {"start": 1319.53, "end": 1319.71, "word": " كل", "probability": 0.93212890625}, {"start": 1319.71, "end": 1320.15, "word": " العناصر", "probability": 0.93798828125}, {"start": 1320.15, "end": 1320.27, "word": " اللي", "probability": 0.95556640625}, {"start": 1320.27, "end": 1320.55, "word": " فيها", "probability": 0.988525390625}], "temperature": 1.0}, {"id": 53, "seek": 134967, "start": 1321.75, "end": 1349.67, "text": "مش ضروري أنا بظهر بس حاسس .. لإن لو كنت أتكلم على قائمة فيها خمسين element فانت بدي أكبر من حجم الشاشة عشان أعرضها و بحتاج لمين لـ scroll الآن مع ال J list ال constructor بياخد مني list عشان إيش بدي أعرض list of colors السابقة اللي عرضناها في ال spinner هي اللي أنا بدي أضيفها لل list هي ال list و بدي أظهر عليها في داخلها الألوان الخمسة اللي احنا كاتبينهم", "tokens": [2304, 8592, 48812, 2288, 13063, 1829, 41850, 4724, 19913, 3224, 2288, 4724, 3794, 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0.969970703125}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.9921875}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.993896484375}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.96728515625}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.9921875}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.9940185546875}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.9638671875}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.99169921875}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.9940185546875}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.959716796875}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.990234375}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.993896484375}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.95654296875}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.98974609375}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.9937744140625}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.953369140625}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.98876953125}, {"start": 1801.14, "end": 1801.14, "word": " عنصر", "probability": 0.993408203125}, {"start": 1801.14, "end": 1801.14, "word": " واحد", "probability": 0.94873046875}, {"start": 1801.14, "end": 1801.14, "word": " من", "probability": 0.98779296875}, {"start": 1801.14, "end": 1801.16, "word": " عنصر", "probability": 0.9931640625}, {"start": 1801.16, "end": 1801.16, "word": " واحد", "probability": 0.94482421875}, {"start": 1801.16, "end": 1801.16, "word": " من", "probability": 0.986328125}, {"start": 1801.16, "end": 1801.16, "word": " عنصر", "probability": 0.992919921875}, {"start": 1801.16, "end": 1801.16, "word": " واحد", "probability": 0.940185546875}, {"start": 1801.16, "end": 1801.16, "word": " من", "probability": 0.9853515625}, {"start": 1801.16, "end": 1801.16, "word": " عنصر", "probability": 0.992919921875}, {"start": 1801.16, "end": 1801.16, "word": " واحد", "probability": 0.935546875}, {"start": 1801.16, "end": 1801.16, "word": " من", "probability": 0.982421875}, {"start": 1801.16, "end": 1801.16, "word": " عنصر", "probability": 0.99267578125}, {"start": 1801.16, "end": 1801.2, "word": " واحد", "probability": 0.927490234375}, {"start": 1801.2, "end": 1801.4, "word": " من", "probability": 0.982421875}], "temperature": 1.0}, {"id": 71, "seek": 183045, "start": 1801.51, "end": 1830.45, "text": "فاذا انت قلتله single او multiple selection معناته انت تسمح لل user يعمل click اول مرة على ال element وينتقل على element اخر يعمل كمان مرة click عشان يختار عنصرين عن القائمة يعني فيك تقول على سبيل المثال نحط ال hobbies الهوايات في list زي هيك و اقول له اختار انت ايش العناصر اللي عندك بدل ما يكون في عندك check box في اي سؤال تاني يا بنات؟", "tokens": [5172, 45636, 995, 16472, 2655, 12174, 1211, 2655, 43761, 2167, 1975, 2407, 3866, 9450, 20449, 8315, 47395, 16472, 2655, 6055, 38251, 5016, 24976, 4195, 7251, 25957, 1211, 2052, 1975, 12610, 3714, 25720, 15844, 2423, 4478, 4032, 9957, 2655, 4587, 1211, 15844, 4478, 1975, 34740, 7251, 25957, 1211, 9122, 2304, 7649, 3714, 25720, 2052, 6225, 8592, 7649, 7251, 46456, 9640, 18871, 9381, 2288, 9957, 18871, 25062, 16373, 46007, 37495, 22653, 8978, 4117, 6055, 39648, 15844, 8608, 21292, 1211, 9673, 12984, 6027, 8717, 5016, 9566, 2423, 35750, 2423, 3224, 14407, 1829, 9307, 8978, 1329, 30767, 1829, 39896, 4117, 4032, 1975, 39648, 46740, 1975, 46456, 9640, 16472, 2655, 1975, 1829, 8592, 18863, 1863, 33546, 2288, 13672, 1829, 43242, 4117, 47525, 1211, 19446, 7251, 30544, 8978, 43242, 4117, 1520, 2424, 8978, 1975, 1829, 8608, 33604, 6027, 6055, 7649, 1829, 35186, 4724, 8315, 2655, 22807], "avg_logprob": -0.19281915316345, "compression_ratio": 1.8154362416107384, "no_speech_prob": 0.0, "words": [{"start": 1801.51, "end": 1801.83, "word": "فاذا", "probability": 0.5664876302083334}, {"start": 1801.83, "end": 1802.03, "word": " انت", "probability": 0.7421875}, {"start": 1802.03, "end": 1802.55, "word": " قلتله", "probability": 0.8140869140625}, {"start": 1802.55, "end": 1803.15, "word": " single", "probability": 0.5146484375}, {"start": 1803.15, "end": 1803.87, "word": " او", "probability": 0.7398681640625}, {"start": 1803.87, "end": 1804.35, "word": " multiple", "probability": 0.82861328125}, {"start": 1804.35, "end": 1805.81, "word": " selection", "probability": 0.8837890625}, {"start": 1805.81, "end": 1806.65, "word": " معناته", "probability": 0.7820638020833334}, {"start": 1806.65, "end": 1806.83, "word": " انت", "probability": 0.7392578125}, {"start": 1806.83, "end": 1807.27, "word": " تسمح", "probability": 0.8527018229166666}, {"start": 1807.27, "end": 1807.49, "word": " لل", "probability": 0.52734375}, {"start": 1807.49, "end": 1807.87, "word": " user", "probability": 0.441162109375}, {"start": 1807.87, "end": 1808.67, "word": " يعمل", "probability": 0.97607421875}, {"start": 1808.67, "end": 1808.99, "word": " click", "probability": 0.6943359375}, {"start": 1808.99, "end": 1809.31, "word": " اول", "probability": 0.767822265625}, {"start": 1809.31, "end": 1809.57, "word": " مرة", "probability": 0.98779296875}, {"start": 1809.57, "end": 1809.75, "word": " على", "probability": 0.7998046875}, {"start": 1809.75, "end": 1809.87, "word": " ال", "probability": 0.93359375}, {"start": 1809.87, "end": 1810.23, "word": " element", "probability": 0.943359375}, {"start": 1810.23, "end": 1811.45, "word": " وينتقل", "probability": 0.937890625}, {"start": 1811.45, "end": 1811.59, "word": " على", "probability": 0.66552734375}, {"start": 1811.59, "end": 1811.93, "word": " element", "probability": 0.6015625}, {"start": 1811.93, "end": 1812.31, "word": " اخر", "probability": 0.8984375}, {"start": 1812.31, "end": 1812.59, "word": " يعمل", "probability": 0.92529296875}, {"start": 1812.59, "end": 1812.87, "word": " كمان", "probability": 0.9475911458333334}, {"start": 1812.87, "end": 1813.15, "word": " مرة", "probability": 0.9794921875}, {"start": 1813.15, "end": 1814.13, "word": " click", "probability": 0.470703125}, {"start": 1814.13, "end": 1814.41, "word": " عشان", "probability": 0.97216796875}, {"start": 1814.41, "end": 1814.85, "word": " يختار", "probability": 0.9973958333333334}, {"start": 1814.85, "end": 1816.31, "word": " عنصرين", "probability": 0.9808349609375}, {"start": 1816.31, "end": 1816.53, "word": " عن", "probability": 0.93701171875}, {"start": 1816.53, "end": 1817.69, "word": " القائمة", "probability": 0.9851888020833334}, {"start": 1817.69, "end": 1818.07, "word": " يعني", "probability": 0.940673828125}, {"start": 1818.07, "end": 1818.31, "word": " فيك", "probability": 0.89013671875}, {"start": 1818.31, "end": 1818.73, "word": " تقول", "probability": 0.9091796875}, {"start": 1818.73, "end": 1818.93, "word": " على", "probability": 0.1700439453125}, {"start": 1818.93, "end": 1819.23, "word": " سبيل", "probability": 0.9895833333333334}, {"start": 1819.23, "end": 1819.73, "word": " المثال", "probability": 0.9871419270833334}, {"start": 1819.73, "end": 1820.49, "word": " نحط", "probability": 0.6654052734375}, {"start": 1820.49, "end": 1820.65, "word": " ال", "probability": 0.95556640625}, {"start": 1820.65, "end": 1820.97, "word": " hobbies", "probability": 0.65234375}, {"start": 1820.97, "end": 1821.81, "word": " الهوايات", "probability": 0.92822265625}, {"start": 1821.81, "end": 1822.41, "word": " في", "probability": 0.85302734375}, {"start": 1822.41, "end": 1822.63, "word": " list", "probability": 0.8662109375}, {"start": 1822.63, "end": 1822.91, "word": " زي", "probability": 0.9814453125}, {"start": 1822.91, "end": 1823.45, "word": " هيك", "probability": 0.935546875}, {"start": 1823.45, "end": 1823.91, "word": " و", "probability": 0.92333984375}, {"start": 1823.91, "end": 1824.09, "word": " اقول", "probability": 0.6640625}, {"start": 1824.09, "end": 1824.19, "word": " له", "probability": 0.41845703125}, {"start": 1824.19, "end": 1824.51, "word": " اختار", "probability": 0.9763997395833334}, {"start": 1824.51, "end": 1824.79, "word": " انت", "probability": 0.753662109375}, {"start": 1824.79, "end": 1825.05, "word": " ايش", "probability": 0.778076171875}, {"start": 1825.05, "end": 1825.95, "word": " العناصر", "probability": 0.8426513671875}, {"start": 1825.95, "end": 1826.03, "word": " اللي", "probability": 0.84130859375}, {"start": 1826.03, "end": 1826.23, "word": " عندك", "probability": 0.9931640625}, {"start": 1826.23, "end": 1826.45, "word": " بدل", "probability": 0.965576171875}, {"start": 1826.45, "end": 1826.53, "word": " ما", "probability": 0.93701171875}, {"start": 1826.53, "end": 1826.65, "word": " يكون", "probability": 0.863037109375}, {"start": 1826.65, "end": 1826.73, "word": " في", "probability": 0.8408203125}, {"start": 1826.73, "end": 1826.89, "word": " عندك", "probability": 0.805908203125}, {"start": 1826.89, "end": 1827.05, "word": " check", "probability": 0.9287109375}, {"start": 1827.05, "end": 1827.31, "word": " box", "probability": 0.64404296875}, {"start": 1827.31, "end": 1829.29, "word": " في", "probability": 0.546875}, {"start": 1829.29, "end": 1829.39, "word": " اي", "probability": 0.898193359375}, {"start": 1829.39, "end": 1829.57, "word": " سؤال", "probability": 0.9957682291666666}, {"start": 1829.57, "end": 1829.79, "word": " تاني", "probability": 0.97265625}, {"start": 1829.79, "end": 1829.89, "word": " يا", "probability": 0.5068359375}, {"start": 1829.89, "end": 1830.45, "word": " بنات؟", "probability": 0.9205322265625}], "temperature": 1.0}, {"id": 72, "seek": 183188, "start": 1831.12, "end": 1831.88, "text": "في أي سؤال؟", "tokens": [41185, 36632, 8608, 33604, 6027, 22807], "avg_logprob": -0.27455357142857145, "compression_ratio": 0.7407407407407407, "no_speech_prob": 0.0, "words": [{"start": 1831.12, "end": 1831.34, "word": "في", "probability": 0.300048828125}, {"start": 1831.34, "end": 1831.42, "word": " أي", "probability": 0.5419921875}, {"start": 1831.42, "end": 1831.88, "word": " سؤال؟", "probability": 0.979248046875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1832.3795, "duration_after_vad": 1728.532499999994}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/xywTHerTtvo_postprocess.srt b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/xywTHerTtvo_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..535657017c5c8a95a36a097bae5442ae2edf5bb5
--- /dev/null
+++ b/PL9fwy3NUQKwZi1D8m-yUwwgUG3qk8h9pL/xywTHerTtvo_postprocess.srt
@@ -0,0 +1,1928 @@
+1
+00:00:21,510 --> 00:00:23,150
+بسم الله الرحمن الرحيم الصلاة والسلام عليك ورحمة
+
+2
+00:00:23,150 --> 00:00:26,610
+الله طيب أهلا وسهلا فيكم في المحاضرة الثانية في ال
+
+3
+00:00:26,610 --> 00:00:31,910
+exception كنا اللقاء الماضي اتكلمنا على exception
+
+4
+00:00:31,910 --> 00:00:35,730
+وقلنا هي عبارة عن الأخطاء اللي بتظهر أثناء ال run
+
+5
+00:00:35,730 --> 00:00:39,130
+-time أو بشكل عام الأخطاء بالجاذب بتندرج أو بتنقسم
+
+6
+00:00:39,130 --> 00:00:43,170
+لنوعين ال error و ال exception واتفقنا أن ال error
+
+7
+00:00:43,170 --> 00:00:46,830
+هو عبارة عن خطأالـ Java Virtual Machine أو في الـ
+
+8
+00:00:46,830 --> 00:00:50,850
+Operating System في الآخر مفاده خطأ إنه نتج لكن مش
+
+9
+00:00:50,850 --> 00:00:54,750
+أنت المسؤول عنه مش برنامجك المسؤول عنه وهنا مافيش
+
+10
+00:00:54,750 --> 00:00:59,320
+قدام الخياراتغالباً هنعمل terminate لل application
+
+11
+00:00:59,320 --> 00:01:03,560
+تبعي احنا بنتكلم عن ال exception اللي بينتج عن
+
+12
+00:01:03,560 --> 00:01:07,440
+نشاط البرنامج تبعك الخطأ المعين في ال code تقسيم
+
+13
+00:01:07,440 --> 00:01:11,420
+على صفر اذا دعيت index مش موجود الى اخره فهذا
+
+14
+00:01:11,420 --> 00:01:15,340
+الخطأ مسئوليتك انت وهذا هو الخطأ اللي احنا بنقدر
+
+15
+00:01:15,340 --> 00:01:20,670
+فعاليا نتحكم فيه ونحله واتفقناإن هاي الكلية اللي
+
+16
+00:01:20,670 --> 00:01:24,010
+بتوفرها الجاها من ناحية ال exception كل حاجة
+
+17
+00:01:24,010 --> 00:01:27,670
+extend from throwable و أنا بتكلم حتى ال error
+
+18
+00:01:27,670 --> 00:01:30,490
+كمان extend من ال throwable في الآخر أنا بحاجة
+
+19
+00:01:30,490 --> 00:01:33,410
+أعمل تحت ال exception وما ينطوي تحتها من ال run
+
+20
+00:01:33,410 --> 00:01:39,150
+-time و ال input output exception و لما اتكلمنا
+
+21
+00:01:39,150 --> 00:01:43,530
+على الأمثلة قلنا ممكن انا زي ما قلنا قبل شوية ممكن
+
+22
+00:01:43,530 --> 00:01:47,860
+أستدعي index مش موجودأو فيه أروح أعمل casting بشكل
+
+23
+00:01:47,860 --> 00:01:52,980
+غير موفق أو فعليا أجسم على صفر أو أحط سالب تحت
+
+24
+00:01:52,980 --> 00:01:56,580
+الجذر إلى آخره ففي الآخر سيظهر في عندي exception
+
+25
+00:01:56,580 --> 00:02:01,180
+ال exception هذا مفادق الان احنا متفقين أو ال
+
+26
+00:02:01,180 --> 00:02:03,620
+layers تبعتنا اللي رسلناها المرة الماضية قولنا ال
+
+27
+00:02:03,620 --> 00:02:10,100
+program code ال java virtual machine و ال
+
+28
+00:02:10,100 --> 00:02:13,920
+operating systemالان الـ Java Code أو الـ Java
+
+29
+00:02:13,920 --> 00:02:15,820
+Virtual Machine بتاخد الكود اللي عندك، الـ
+
+30
+00:02:15,820 --> 00:02:18,380
+instructions اللي عندك، و بتبعت لل operating
+
+31
+00:02:18,380 --> 00:02:21,420
+system نفذ، و ال output طبعا ضال ال response بين
+
+32
+00:02:21,420 --> 00:02:23,140
+البرنامج .. بين ال operating system و ال Java
+
+33
+00:02:23,140 --> 00:02:25,760
+Virtual Machine في لحظة من اللحظات صار في خطأ
+
+34
+00:02:25,760 --> 00:02:29,120
+بتروح ال Java Virtual Machine بتعمل erase لل
+
+35
+00:02:29,120 --> 00:02:33,300
+application تبعك، ان في عندي خطأعملت arrest يعني
+
+36
+00:02:33,300 --> 00:02:36,000
+عملت notification عملت notification إنه صار في
+
+37
+00:02:36,000 --> 00:02:40,720
+عندي خطأ الخطأ هذا إذا البرنامج تابعك جاهز يستقبله
+
+38
+00:02:40,720 --> 00:02:45,300
+و يشوف إيش المشكلة و يتجوزها كان بها مافيش فال
+
+39
+00:02:45,300 --> 00:02:47,940
+Java Virtual Machine هتعمل terminate لل
+
+40
+00:02:47,940 --> 00:02:52,950
+application اللي موجود عندناوقلنا بما أن الـ Java
+
+41
+00:02:52,950 --> 00:02:56,670
+Virtual Machine هتعمل Erase معناته أنه بحتاج لجملة
+
+42
+00:02:56,670 --> 00:03:01,370
+أو كلمة تمسك أو توضح وين ممكن يصير الخطأ اللي عندي
+
+43
+00:03:01,370 --> 00:03:04,490
+واتفقنا إنه لو في عندي أربع كلمات أساسية أو تلت
+
+44
+00:03:04,490 --> 00:03:06,990
+كلمات أساسية اللي احنا شوفناهم في المحاضرة الماضية
+
+45
+00:03:06,990 --> 00:03:12,970
+try و catch و finally و جينا قولنا في ترتيبهم أو
+
+46
+00:03:12,970 --> 00:03:18,370
+في التعامل معاهم كتالي try بكتب في داخلها الجملة
+
+47
+00:03:18,370 --> 00:03:23,180
+أو ال code اللي محتملهو اللي يصدر عنه الخطأ يعني
+
+48
+00:03:23,180 --> 00:03:27,500
+لو أنا ممكن أكون في عندي أكتر من جملة و الجملة هذه
+
+49
+00:03:27,500 --> 00:03:31,600
+هي اللي ممكن تصدر الخطأ اللي موجود و الله لو كانت
+
+50
+00:03:31,600 --> 00:03:34,620
+الجملة ال execution تابعي اشتغل تمام و هذه الجملة
+
+51
+00:03:34,620 --> 00:03:39,240
+ماصدرتش خطأ خلاص البرنامج بنفذ ال try بنفذ ال try
+
+52
+00:03:39,240 --> 00:03:45,120
+و باتجاه ال catch و بروح بنفذ ال finally
+
+53
+00:03:50,000 --> 00:03:55,180
+صار في عندي خطأ في الجملة 2 بيعمل ignore لكل ال
+
+54
+00:03:55,180 --> 00:03:58,900
+statements اللي بعد الخطأ هذا و بينتقل مباشرة
+
+55
+00:03:58,900 --> 00:04:04,060
+لوين؟ على ال catch إذا الخطأ موجود بعمله catch
+
+56
+00:04:04,060 --> 00:04:08,100
+بمعنى آخر فبروح بعمله hand to hand و بكمل
+
+57
+00:04:08,100 --> 00:04:11,200
+execution لنهاية البرنامج طبعا هذه نقول نهاية
+
+58
+00:04:11,200 --> 00:04:17,300
+برنامج ال code هنا statement طيب
+
+59
+00:04:18,000 --> 00:04:20,860
+أتي على الـ catch ولم يجد ماتش ماقدرش يمسك الخطأ
+
+60
+00:04:20,860 --> 00:04:25,160
+إيش هو؟ هيروح ينفذ الـ finally و بعدين يعمل
+
+61
+00:04:25,160 --> 00:04:28,280
+terminate لل application يعني ال statement هذه مش
+
+62
+00:04:28,280 --> 00:04:32,800
+هتتنفذ هكذا في الحالة الأولى مافيش خطأ هينفذ ال
+
+63
+00:04:32,800 --> 00:04:35,440
+try هينفذ ال finally و هينفذ ال statement اللي في
+
+64
+00:04:35,440 --> 00:04:41,230
+الآخرTry صار فيها خطأ، فهيعمل Ignore لباقي الـTry
+
+65
+00:04:41,230 --> 00:04:44,770
+ويروح على الـCatch في الـCatch عندي حالتين إذا
+
+66
+00:04:44,770 --> 00:04:50,210
+الـException تم مسكه هان أو عمله match، هيعمل
+
+67
+00:04:50,210 --> 00:04:56,290
+execution للـCatch ومن ثم ينتقل لـTry ويكمل
+
+68
+00:04:56,290 --> 00:05:01,030
+الـExecution للنقل الـFinal و النهايةطيب مامسكش ال
+
+69
+00:05:01,030 --> 00:05:05,490
+catch ال exception اللي طلع عندي بنفذ final و بعمل
+
+70
+00:05:05,490 --> 00:05:09,230
+exit من ال application اللي موجود عندي وهذا الكلام
+
+71
+00:05:09,230 --> 00:05:12,710
+احنا وصلناه وشوفناه اللقاء الماضي في حد عنده اي
+
+72
+00:05:12,710 --> 00:05:17,470
+سؤال يا بنات؟ من هناك في على هات كلام؟ اليوم
+
+73
+00:05:17,470 --> 00:05:20,810
+المصطلح الأخير اللي هنتكلم عليه اللي هو ال throw
+
+74
+00:05:20,810 --> 00:05:23,990
+لما
+
+75
+00:05:23,990 --> 00:05:29,270
+انا بجي بتكلم على ال throwمعناته أنا بدي أكون
+
+76
+00:05:29,270 --> 00:05:33,310
+مسئول أو بدي أعمل Erase لـException Manually احنا
+
+77
+00:05:33,310 --> 00:05:36,410
+قبل شوية لما رسمنا Hangul الخطأ المسئول عن إرسال
+
+78
+00:05:36,410 --> 00:05:40,710
+أو اظهار الخطأ الـJava Virtual Machine وبالتالي هو
+
+79
+00:05:40,710 --> 00:05:43,590
+Automatically Erased بتم الـ Announcement أو
+
+80
+00:05:43,590 --> 00:05:47,450
+الإعلان عنه بشكل تلقائي لكن لو أنا تدخلت ك
+
+81
+00:05:47,450 --> 00:05:52,950
+Programmer و بقدر أروح أعملException او Arrays لـ
+
+82
+00:05:52,950 --> 00:05:56,390
+Exception طيب انا بقدر اعمل Arrays لـ Exception
+
+83
+00:05:56,390 --> 00:06:00,270
+وبالتالي اذا ماكنتش حاط .. حاط الجملة ضمن ال try
+
+84
+00:06:00,270 --> 00:06:06,070
+معناته هاروح وين على exception و هعمل terminate لل
+
+85
+00:06:06,070 --> 00:06:08,850
+application تبعتي لكن جابل ما انا اروح باتجاه ال
+
+86
+00:06:08,850 --> 00:06:12,270
+throw تعالى نشوف الحالة اللى انا بدى اتكلم عليها
+
+87
+00:06:12,270 --> 00:06:17,470
+لان في داخل الجوانت كنت تشتغل برنامج لبنكبحيث أنه
+
+88
+00:06:17,470 --> 00:06:20,050
+بدك تنفذ ال execution تبع ال withdrawal السحب
+
+89
+00:06:20,050 --> 00:06:26,470
+عملية السحب الآن المنطق بيقول أنا بدي أسحب مبلغ من
+
+90
+00:06:26,470 --> 00:06:31,610
+الرصيد فلازم أفحص هل الكمية المطلوبة هذه أقل أو
+
+91
+00:06:31,610 --> 00:06:35,850
+تساوي الرصيد كحد قادة ولا لا؟ طيب فأنا ممكن أروح
+
+92
+00:06:35,850 --> 00:06:41,450
+أقوله if ال amount أقل أو equal ال balance أو أقل
+
+93
+00:06:41,450 --> 00:06:46,800
+من ال balance لو تحقق الشرط هذابنفذ طب لو ما تحققش
+
+94
+00:06:46,800 --> 00:06:50,780
+يعني كانت ال amount أكبر من ال balance إيش المفروض
+
+95
+00:06:50,780 --> 00:06:54,820
+يصير؟ هو خطأ أيوة هو المفروض يصير فيه خطأ بس شوية
+
+96
+00:06:54,820 --> 00:06:57,300
+هو exception و exception لأنه أنا اللي بدي أرمي
+
+97
+00:06:57,300 --> 00:07:01,860
+exception بس هل .. هل .. هل .. هل منطق هذا إنه أنا
+
+98
+00:07:01,860 --> 00:07:04,600
+أرمي error أو خلّي ال Java virtually تعمل
+
+99
+00:07:04,600 --> 00:07:07,960
+terminate؟ هذه العملية أساسا اسمها validation صح؟
+
+100
+00:07:12,290 --> 00:07:15,890
+أساسا بالـ validation أنا المفروض أتجنب وقوع الـ
+
+101
+00:07:15,890 --> 00:07:19,370
+error أتجنب الـ exception يعني إذا أنا بافحص أروح
+
+102
+00:07:19,370 --> 00:07:24,730
+أعمل terminate مشكلة يعني أنا جاعد بافحص و أقول له
+
+103
+00:07:24,730 --> 00:07:28,650
+ال amount اللي بتسحبها أكبر طيب تعالى نشوف مثال
+
+104
+00:07:28,650 --> 00:07:32,970
+تاني لأ لما أنا روحته قلتله A على B و كانت قيمة
+
+105
+00:07:32,970 --> 00:07:33,490
+الـ B 0
+
+106
+00:07:37,600 --> 00:07:43,620
+Integer X بدأ تساوي A على B أو 7 على B من المسئول
+
+107
+00:07:43,620 --> 00:07:47,960
+عن الجسم هاي؟ مش أنا؟ مش بإمكاني كنت أتجنب ظهور
+
+108
+00:07:47,960 --> 00:07:52,040
+الـ arithmetic exception لو أنا روحت و حصلت و قلت
+
+109
+00:07:52,040 --> 00:07:59,860
+له if ال B equal 0 معناته اطبع لل .. مقدرش أجسم
+
+110
+00:07:59,860 --> 00:08:04,060
+على صفر و أروح دخلها مرة تانية مش بصير؟ و هيك أنا
+
+111
+00:08:04,060 --> 00:08:09,530
+بكون تجنبت أساسا حدوة الخطأطيب، متى أنا ممكن ألجأ
+
+112
+00:08:09,530 --> 00:08:14,790
+أو أروح باتجاه إنه أعمل الـThrow للـException هذا
+
+113
+00:08:14,790 --> 00:08:19,690
+بدل ما أنا بدي أعالجه؟ في حالة واحدة، إذا أنا كان
+
+114
+00:08:19,690 --> 00:08:23,410
+فيه ناس هي المسؤولة عن العملية دي هيك أجوا قالولي،
+
+115
+00:08:23,410 --> 00:08:27,850
+وإحنا بدنا نعمل method مهمتها تسحب من الرصيد
+
+116
+00:08:27,850 --> 00:08:34,510
+مهمتها تسحب من الرصيدومدونيش تفاصيل، مدونيش تفاصيل
+
+117
+00:08:34,510 --> 00:08:38,710
+عشان أسحب من الرصيف بالدفحص لو كان ال balance أكبر
+
+118
+00:08:38,710 --> 00:08:43,070
+أو ساوى ال amount بقدر أسحب و أقول في الآخر ال
+
+119
+00:08:43,070 --> 00:08:46,570
+balance equal ال balance نقص ال amount و لا لا و
+
+120
+00:08:46,570 --> 00:08:49,370
+خلصنا لكن لو كانت ال amount أكبر من ال balance
+
+121
+00:08:49,370 --> 00:08:55,170
+مدونيش تفاصيل إيش ممكن يساوي في ال method هاي بهيك
+
+122
+00:08:55,170 --> 00:08:59,300
+أنا بروح بعمل eraseتمام؟ واللي هيستخدم ال
+
+123
+00:08:59,300 --> 00:09:01,880
+application بعدين هيفهم ان هذه الجملة ايش عمالة
+
+124
+00:09:01,880 --> 00:09:06,920
+بتعمل بتدي exception او فيها error وبالتالي هو
+
+125
+00:09:06,920 --> 00:09:11,680
+هيعمل catch لل error هذا وين؟ ويعمل handling في
+
+126
+00:09:11,680 --> 00:09:16,960
+داخل ال catch حسب اللي عنده طيب تمام تعالى نشوف او
+
+127
+00:09:16,960 --> 00:09:20,580
+ايش ممكن انا او كيف ممكن انا ا read me او اظهر
+
+128
+00:09:20,580 --> 00:09:24,440
+exception هستخدم throw
+
+129
+00:09:26,360 --> 00:09:32,180
+throw و بدي أخد object من exception و بدي أخد
+
+130
+00:09:32,180 --> 00:09:36,040
+object من exception و بدي أخد object من exception
+
+131
+00:09:36,040 --> 00:09:39,600
+الـ new إيش ما كان ال object اللي عندي كان بتقدر
+
+132
+00:09:39,600 --> 00:09:48,840
+تغيري ال code تبعتها من ناحية عملية هي
+
+133
+00:09:48,840 --> 00:09:54,870
+أنا الآن راح أقول له integera equals 7 مثلا زي
+
+134
+00:09:54,870 --> 00:09:59,010
+المثال التابع المرة الماضية integer b equals zero
+
+135
+00:09:59,010 --> 00:10:02,050
+الآن
+
+136
+00:10:02,050 --> 00:10:15,530
+هروح أقوله if ال b equals zero throw
+
+137
+00:10:15,530 --> 00:10:19,210
+new arithmetic
+
+138
+00:10:26,180 --> 00:10:30,860
+arithmetic exception وممكن انا اغير ال message
+
+139
+00:10:30,860 --> 00:10:36,020
+اللي انا بدي اياها cannot
+
+140
+00:10:36,020 --> 00:10:42,440
+divide
+
+141
+00:10:42,440 --> 00:10:46,160
+divide
+
+142
+00:10:46,160 --> 00:10:52,660
+by zero حيث if else
+
+143
+00:10:59,880 --> 00:11:06,760
+هروح أقول له system out أطبع لي اللي هي ال A على B
+
+144
+00:11:06,760 --> 00:11:10,440
+هاي
+
+145
+00:11:10,440 --> 00:11:17,460
+في حالة كانت اتنين سبعة على اتنين وعملت run كتب لي
+
+146
+00:11:17,460 --> 00:11:27,240
+تلاتة صح؟ حولت ال B لصفر هاي run save ايش راح
+
+147
+00:11:27,240 --> 00:11:31,760
+جليه؟اللي فيه عندك exception اللي فيه عند إيه
+
+148
+00:11:31,760 --> 00:11:38,080
+exception arithmetic exception cannot divide by
+
+149
+00:11:38,080 --> 00:11:42,400
+zero طبعا عشان أحل هيك المشكلة إيش بدي أساوي؟ بدي
+
+150
+00:11:42,400 --> 00:11:48,160
+أحط ال statement تبعتها دي في داخل try و catch
+
+151
+00:11:48,160 --> 00:11:55,480
+يعني هيك أقوله try وهي
+
+152
+00:11:55,480 --> 00:11:56,420
+نهاية ال else
+
+153
+00:11:59,210 --> 00:12:05,670
+catch و بال catch قولنا بنستخدم اي arithmetic اذا
+
+154
+00:12:05,670 --> 00:12:13,030
+احنا بدأنا نشتغل arithmetic exception اي اي مثلا
+
+155
+00:12:13,030 --> 00:12:25,670
+اقوله cess out cannot divide cannot
+
+156
+00:12:25,670 --> 00:12:27,750
+divide
+
+157
+00:12:29,350 --> 00:12:40,810
+by zero وبالتالي هي slash in enter new
+
+158
+00:12:40,810 --> 00:12:48,250
+b بصير؟ بصير، بس عشان أنفذ القيمة هذه بدي أكمل
+
+159
+00:12:48,250 --> 00:12:52,310
+تابعات الشغل اللي بتوصير عليها و الأمور بتكون في
+
+160
+00:12:52,310 --> 00:12:58,580
+ال save site القصد إذا أنا بدي أعمل throwمعناته
+
+161
+00:12:58,580 --> 00:13:02,740
+لازم أعمل handle exception والهدف كمان مرة أن
+
+162
+00:13:02,740 --> 00:13:05,780
+أورجيك أنه بإمكانك تعمل throw exception manually
+
+163
+00:13:05,780 --> 00:13:11,900
+تعمل throw exception manually طيب هذا الكلام حتى
+
+164
+00:13:11,900 --> 00:13:17,080
+الآن okay لكن برجع بنقول الأصل أن أنا ماعملش
+
+165
+00:13:17,080 --> 00:13:21,180
+exception manually الأصل أن أعمل validation واتأكد
+
+166
+00:13:21,180 --> 00:13:24,400
+من القيم تبعتي أفضل من أن أعمل exception
+
+167
+00:13:31,290 --> 00:13:34,210
+عارفة ليش؟ ما هي الكلام اللي أنا قاعد بقوله لإن
+
+168
+00:13:34,210 --> 00:13:38,450
+انت عاملة validation نصبوت؟
+
+169
+00:13:38,450 --> 00:13:43,190
+الأصل مايكونش ال action تبعي هيكوفي نفس الوقت ما
+
+170
+00:13:43,190 --> 00:13:48,230
+يمكنني أن أضع هذا الـ throw في نص الكود بدون أن
+
+171
+00:13:48,230 --> 00:13:50,330
+يكون عليها condition لأن كل ما أريد أن أقوم بالـ
+
+172
+00:13:50,330 --> 00:13:53,490
+execution ستعمل الـ throw كمان مرة الهدف الرئيسي
+
+173
+00:13:53,490 --> 00:13:57,790
+هنا هو أن أريك أن بإمكاني أعمل arrays لـ exception
+
+174
+00:13:57,790 --> 00:14:05,590
+manually أعمل arrays لـ exception manually أكيد
+
+175
+00:14:05,590 --> 00:14:10,970
+لأن .. ليش .. في أي .. ليش بتحط try و catch؟عشان
+
+176
+00:14:10,970 --> 00:14:13,590
+تضمن ان البرنامج سامعك حيستمر في ال execution لانه
+
+177
+00:14:13,590 --> 00:14:17,230
+لم يعمل ترمينات في الحالة .. هيها .. في الحالة
+
+178
+00:14:17,230 --> 00:14:20,530
+اللي مافيش عندي try و catch يعني أقصد مثلا لو أنا
+
+179
+00:14:20,530 --> 00:14:23,090
+في ال catch ماكنتش رميها بالأدب مافي ال execution
+
+180
+00:14:23,090 --> 00:14:26,110
+و أنا رميها في ال B و في ال F ده هيأثر من هناك
+
+181
+00:14:26,110 --> 00:14:31,330
+تمام؟ هي .. هي ال F ده هتشتغل ولا مش هتشتغل حسب ال
+
+182
+00:14:31,330 --> 00:14:34,190
+data اللي حسب ال B اللي عندي فوق هتشتغل يعني
+
+183
+00:14:34,190 --> 00:14:39,240
+أحيانا أعمل ال throw تمامتمام؟ لو أنا أجيت هنا
+
+184
+00:14:39,240 --> 00:14:51,060
+بعيدة عن الـ Else هاي system out end of main تمام؟
+
+185
+00:14:51,060 --> 00:14:54,200
+الآن هد عمرها هتتنفذ في الحالة الهادي ولا عمرها،
+
+186
+00:14:54,200 --> 00:14:58,740
+ليش؟ لأن فعليا البرنامج بمجرد بنعمله throw صار في
+
+187
+00:14:58,740 --> 00:15:02,180
+عنده exception مش معمول له handling فبنعمل crash
+
+188
+00:15:02,180 --> 00:15:06,680
+مبسوط ولا لأ؟ فعشان هيك أنا لجأت إش أساويأعمل
+
+189
+00:15:06,680 --> 00:15:10,160
+التركاتش لكن لو كانت الـ B مثلا equal واحد و نفذت
+
+190
+00:15:10,160 --> 00:15:16,080
+مافيش مشكلة لأن أساسا ماظهرش الخطأ اللي موجود عندك
+
+191
+00:15:16,080 --> 00:15:20,940
+و بنرجع بنقول كمان مرة لـ trend ل trend إذا أنا
+
+192
+00:15:20,940 --> 00:15:23,640
+بدي أعمل validation على ال value مافيش داعي أن
+
+193
+00:15:23,640 --> 00:15:27,670
+أروح أعمل throw an exceptionمافيش داعي ان انا اروح
+
+194
+00:15:27,670 --> 00:15:31,250
+اعمل throw ل exception لكن احنا بنقول هذه هي
+
+195
+00:15:31,250 --> 00:15:33,510
+الحالة اللي انا بعمل فيها throw ل exception
+
+196
+00:15:33,510 --> 00:15:36,870
+manually في حالة تانية بعمل throw ل exception
+
+197
+00:15:36,870 --> 00:15:42,570
+manually من خلال جملة اسمها throws هلا قد بنورجكوا
+
+198
+00:15:42,570 --> 00:15:47,130
+إياها بس قبل في عندي مثال بسيط ضال لاحظي لما انا
+
+199
+00:15:47,130 --> 00:15:51,990
+أخدت arithmetic object او من او أخدت new object من
+
+200
+00:15:51,990 --> 00:15:55,360
+ال arithmetic exception غيرت فيهفي الـ message
+
+201
+00:15:55,360 --> 00:15:59,740
+اللي موجودة عندها بإمكاني كذلك أروح أبني my own
+
+202
+00:15:59,740 --> 00:16:06,080
+exception كيف؟ بدي أعمل class و أعمل extend من
+
+203
+00:16:06,080 --> 00:16:10,060
+مين؟ من ال exception لأنه بما أنه كل ال .. حتى ال
+
+204
+00:16:10,060 --> 00:16:14,020
+arithmetic هذا هو based on ال exception معناه أنه
+
+205
+00:16:14,020 --> 00:16:17,220
+لما أنا بدي أبني my own exception بدي أبنيه على ال
+
+206
+00:16:17,220 --> 00:16:20,260
+exception الأساسي اللي موجود عندها هاي class بسيط
+
+207
+00:16:20,260 --> 00:16:22,840
+new class
+
+208
+00:16:25,410 --> 00:16:32,470
+my exception هاي
+
+209
+00:16:32,470 --> 00:16:41,330
+finish بروح أقول له my exception extends
+
+210
+00:16:41,330 --> 00:16:45,750
+exception طيب،
+
+211
+00:16:45,750 --> 00:16:48,330
+طبعا، بضل بدّي ال constructor
+
+212
+00:16:54,460 --> 00:17:00,360
+my exception بدي أديله string مثالية مثل ال
+
+213
+00:17:00,360 --> 00:17:05,660
+message تبعتي و هستدعي ال super constructor عشان
+
+214
+00:17:05,660 --> 00:17:10,260
+أمرر ال message سوبر
+
+215
+00:17:10,260 --> 00:17:13,920
+بدها ايه
+
+216
+00:17:13,920 --> 00:17:17,100
+تمام،
+
+217
+00:17:17,100 --> 00:17:20,880
+الآن بأقدر هنا أروح أقوله throw
+
+218
+00:17:23,770 --> 00:17:30,930
+my exception طيب،
+
+219
+00:17:30,930 --> 00:17:37,610
+لاحظة إيش جالي الآن؟ و
+
+220
+00:17:37,610 --> 00:17:44,230
+هالزمني أني أستخدم throw و catch و هخلينا نتكلم
+
+221
+00:17:44,230 --> 00:17:46,850
+على شغل كالمفروض أصل تكون في نهاية ال slide اليوم
+
+222
+00:17:46,850 --> 00:17:50,750
+أو في نهاية المحاضرة اليوم اللي هيبتوع النوعين أو
+
+223
+00:17:50,750 --> 00:17:54,230
+ال behavior تبعت ال Java compiler مع ال exception
+
+224
+00:17:54,230 --> 00:18:05,890
+على نوعين في عندي catch exception وفي
+
+225
+00:18:05,890 --> 00:18:10,670
+عندي uncatch exception
+
+226
+00:18:10,670 --> 00:18:17,670
+الآن في ال uncatch أو في ال catch الفكرة كانت
+
+227
+00:18:17,670 --> 00:18:24,520
+تاليةأي exception ممكن يكون ناتج عن خطأ في الـ
+
+228
+00:18:24,520 --> 00:18:29,660
+code هذا ال compiler مايقدر يمسكه يعني قسم على صفر
+
+229
+00:18:29,660 --> 00:18:34,140
+أنك تستخدم index مش موجود كل هذا خطأ أو defect
+
+230
+00:18:34,140 --> 00:18:38,840
+موجودة في ال code عندك طيب وبالتالي ال compiler
+
+231
+00:18:38,840 --> 00:18:42,020
+مايقدر يتعامل مع ال system أو مع ال statement هذه
+
+232
+00:18:42,020 --> 00:18:47,460
+بتدي exception أو لا مثل لو أنا أجيت هناروحت قولت
+
+233
+00:18:47,460 --> 00:18:55,640
+مباشرة هي عندي integer c equal a على b ال compiler
+
+234
+00:18:55,640 --> 00:19:00,660
+مقدرش يتنبأ ان هاد ال statement هتعمل exception
+
+235
+00:19:00,660 --> 00:19:06,930
+فبنقول فيها ان فيها unquot exceptionوبالتالي هذا
+
+236
+00:19:06,930 --> 00:19:11,730
+حيمور ويمكن أنا أسهى عنه ك programer لما يعمل
+
+237
+00:19:11,730 --> 00:19:14,810
+system تبعي أثناء ال test يعمل crash أروح أنتباه و
+
+238
+00:19:14,810 --> 00:19:18,910
+أعالج الخطأ لكن في حالة خطأ زي هذا ال system عرف
+
+239
+00:19:18,910 --> 00:19:23,390
+أنه في عندها exception و من البداية قبل ما يعمل ال
+
+240
+00:19:23,390 --> 00:19:28,430
+first run بروح يقول لي لأ لازم تعمل try و catch
+
+241
+00:19:28,430 --> 00:19:33,800
+لازم تعمل try و catchهذه برضه هنشوفها من خلال الـ
+
+242
+00:19:33,800 --> 00:19:36,820
+Musical Throws اللي موجودة عندهان وبالتالي أنا
+
+243
+00:19:36,820 --> 00:19:42,140
+الآن هذا الخطأ اللي صار عمري مش هقدر أتجاوزه لكن
+
+244
+00:19:42,140 --> 00:19:48,560
+لو أنا أجيت غيرت هان وقلتله arithmetic exception
+
+245
+00:19:48,560 --> 00:19:55,840
+راح الخطأ اللي هان لأنه أساسا الـ exception ال
+
+246
+00:19:55,840 --> 00:20:00,770
+arithmetic exception uncut يعني يعنيمش .. يعني مش
+
+247
+00:20:00,770 --> 00:20:03,970
+حتم الوقوع مش لازم يصير عندي هان هو بيصير في حالات
+
+248
+00:20:03,970 --> 00:20:08,010
+معينة تمام؟ وبالتالي صار ال system واضح الآن بين
+
+249
+00:20:08,010 --> 00:20:11,410
+ال quotes .. ال quotes exception او checked عفوا
+
+250
+00:20:11,410 --> 00:20:14,110
+.. it checked مش .. it checked كنت ال exception
+
+251
+00:20:14,110 --> 00:20:20,570
+وانا checked كنت exception طيب .. الآن وبالتالي
+
+252
+00:20:20,570 --> 00:20:25,250
+انا صرت انا برمي ال exception باسم انا بسمله يا و
+
+253
+00:20:25,250 --> 00:20:29,790
+بديله ال message اللي انامحتاجها الحالة التانية
+
+254
+00:20:29,790 --> 00:20:34,590
+والأهم في التعامل مع ال exception ممكن انا اروح
+
+255
+00:20:34,590 --> 00:20:42,390
+اشتغل بالشكل التالي a new class بدي اعمل my
+
+256
+00:20:42,390 --> 00:20:47,890
+methods وفي
+
+257
+00:20:47,890 --> 00:20:54,670
+ال my methods هنا بدي اروح اعرف public static
+
+258
+00:20:54,670 --> 00:20:56,330
+integer
+
+259
+00:20:58,050 --> 00:21:01,370
+method اسمها add طبعا خلّيني في البداية هاي
+
+260
+00:21:01,370 --> 00:21:08,630
+integer a وهي integer b إذا بلزموه، حتى لو ما
+
+261
+00:21:08,630 --> 00:21:13,870
+لزموش مش قضية كتير بالضبط وهي integer a وهي
+
+262
+00:21:13,870 --> 00:21:21,250
+integer b وهنبدأ راح أقوله return a plus ال b
+
+263
+00:21:21,250 --> 00:21:27,250
+السؤال كان التالي ال method هذه ال addهل ممكن يصير
+
+264
+00:21:27,250 --> 00:21:31,830
+منها أخطاء؟ ال code تبعتها هذا هل ممكن ينتج عنه أي
+
+265
+00:21:31,830 --> 00:21:35,110
+خطأ؟ لأ لأن في عنده قيمتين وبيجمعهم مافي مشكلة
+
+266
+00:21:35,110 --> 00:21:38,390
+طبعا هدلبوا المناسبة وممكن انا استغني عنهم
+
+267
+00:21:38,390 --> 00:21:48,550
+لازموناش بينما لو انا عملت كمان method integer
+
+268
+00:21:48,550 --> 00:21:50,110
+تسميها dev
+
+269
+00:21:55,830 --> 00:22:03,890
+integer a و integer b و روحت في ال method هنا end
+
+270
+00:22:03,890 --> 00:22:08,550
+و قلت له return a
+
+271
+00:22:08,550 --> 00:22:15,290
+على b ممكن يصير عندي exception؟ أه ممكن بس أنا
+
+272
+00:22:15,290 --> 00:22:21,420
+بديش أعالج ال exception هذابديش اعالج ال exception
+
+273
+00:22:21,420 --> 00:22:25,860
+هذا مين اللي بدي أخليه يعالجه ال main class هذا هو
+
+274
+00:22:25,860 --> 00:22:35,880
+بمثابة user لل classes اللي موجودة عندها يعني
+
+275
+00:22:35,880 --> 00:22:43,500
+انا بقدر اي جهان اروح اقوله my methods dot انا
+
+276
+00:22:43,500 --> 00:22:50,540
+عرفتهم static صح بروح بقوله dot add هاي واحدو
+
+277
+00:22:50,540 --> 00:22:56,200
+تلاتة أوحا
+
+278
+00:22:56,200 --> 00:23:02,120
+ممكن احنا ده نضغط في داخل system note out عشان
+
+279
+00:23:02,120 --> 00:23:09,780
+اطبعها مباشرة اوكي
+
+280
+00:23:09,780 --> 00:23:16,020
+هنا واحد لازم يكون مافيش عندى مشكلة صح؟ طيب بينما
+
+281
+00:23:16,020 --> 00:23:16,960
+لو استخدمت ال dev
+
+282
+00:23:21,010 --> 00:23:26,950
+هو جاب يخلنا نطن شغل البرنامج بس Ctrl-Z هبدأ أشغل
+
+283
+00:23:26,950 --> 00:23:34,190
+برنامجي طبعليه أربعة Dev حط
+
+284
+00:23:34,190 --> 00:23:38,650
+عليه صفر لإن واحد على تلاتة تلاتة من عشرة و بما إن
+
+285
+00:23:38,650 --> 00:23:43,250
+انتشار بحرر عليه صفر مافيش مشكلة واحد على صفر
+
+286
+00:23:45,820 --> 00:23:48,920
+هيديني exception في الأول خلّيني نشوف ال trace
+
+287
+00:23:48,920 --> 00:23:52,780
+اللي كان او ال printه تستاك ال tracer احنا قولنا
+
+288
+00:23:52,780 --> 00:23:55,920
+بتديني معلومات كاملة عن ال exception تعالى نشوفش
+
+289
+00:23:55,920 --> 00:24:00,900
+قاللي في عندك exceptions صار object من ال
+
+290
+00:24:00,900 --> 00:24:04,060
+arithmetic exception divided by zero ال original
+
+291
+00:24:04,060 --> 00:24:11,180
+message تبعته at my methods الخطأ هذا نتج عن
+
+292
+00:24:12,440 --> 00:24:16,380
+mymethods.dev الفنشن الاسمها dev وفي الصدر الرقم
+
+293
+00:24:16,380 --> 00:24:21,500
+11 وهذه تم استدعاءها الميثود هذه في ال main class
+
+294
+00:24:21,500 --> 00:24:28,680
+dot main الفنشن الاسمها main في الصدر 17 وهذا هو
+
+295
+00:24:28,680 --> 00:24:31,600
+ال trace وبالتالي بتديني معلومات دقيقة طيب الآن
+
+296
+00:24:31,600 --> 00:24:37,340
+إيش الحل أعمل أعمل try و catch أحط ال system out
+
+297
+00:24:37,340 --> 00:24:43,450
+هذه بين try و catchلكن أنا كـ developer أو خلّيني
+
+298
+00:24:43,450 --> 00:24:48,610
+أسميها ك senior developer ممكن إيش أروح أسوي؟ أروح
+
+299
+00:24:48,610 --> 00:24:52,610
+أخلّي ال statement هذه لل caller مانداته ليحطها في
+
+300
+00:24:52,610 --> 00:24:56,390
+ال domain ال try عبر ال .. ال .. ال .. ال clause
+
+301
+00:24:56,390 --> 00:25:05,190
+اللي اسمه throws throws throws إيش؟ exception ال
+
+302
+00:25:05,190 --> 00:25:09,090
+throws exception مباشرةصار في الـ main صار في عندي
+
+303
+00:25:09,090 --> 00:25:13,750
+خطأ هان صار في عندي catch او checked عفوا
+
+304
+00:25:13,750 --> 00:25:17,750
+exception يعني ال compiler قدر يتعرف انه في هان
+
+305
+00:25:17,750 --> 00:25:21,430
+exception ايش صار ايش لازم اساوي الآن لازم احطها
+
+306
+00:25:21,430 --> 00:25:26,070
+ضمن ال try و catch لازم احطها ضمن ال try و catch
+
+307
+00:25:26,070 --> 00:25:27,330
+هاي ال try
+
+308
+00:25:42,300 --> 00:25:53,260
+e dot print tracer أيوة
+
+309
+00:25:53,260 --> 00:25:58,580
+بنت شينكو الآن ال system ألزمني أحط ال statement
+
+310
+00:25:58,580 --> 00:26:02,520
+تبعتي هذه في داخل try و catch طبعا احنا كتبنا
+
+311
+00:26:02,520 --> 00:26:07,450
+كتابةكتبنا كتابة ال ID's غالبا ال clips و ال net
+
+312
+00:26:07,450 --> 00:26:14,130
+pins بإمكانك بمجرد أني أعلمك إياها حددك
+
+313
+00:26:14,130 --> 00:26:20,370
+الخطأ بإمكانك مفتاح الموسي اليمين surround by try
+
+314
+00:26:20,370 --> 00:26:23,630
+and catch فحطيلك إياها ضمن الكود تماما اللي أنا
+
+315
+00:26:23,630 --> 00:26:31,110
+كتبته بدون أي تغيير نعم جايين
+
+316
+00:26:31,110 --> 00:26:37,060
+هصبر عليه شوية هصبر عليه شويةالان في الحالة هدنة
+
+317
+00:26:37,060 --> 00:26:41,120
+تملة عالمين على ال super exception class مظبوط ولا
+
+318
+00:26:41,120 --> 00:26:45,000
+لأ؟ وبالتالي بيّن مباشرة وروحت لو عملت الان
+
+319
+00:26:45,000 --> 00:26:50,600
+execute هيروح يقوللي ان في عندك exception اتظهر
+
+320
+00:26:50,600 --> 00:26:53,740
+عندك exception نوع arithmetic وفي التفاصيل اللي
+
+321
+00:26:53,740 --> 00:26:59,140
+احنا شفناها قبل شوية الان في عندنا مشكلة مع
+
+322
+00:26:59,140 --> 00:27:02,480
+الاثراز في بعض ال exception اللي هي عادة بتكون
+
+323
+00:27:03,510 --> 00:27:07,330
+unchecked exceptions مثل الـ arithmetic و ال non
+
+324
+00:27:07,330 --> 00:27:10,310
+pointer exception يعني الأن لو أنا أتيت في اللحظة
+
+325
+00:27:10,310 --> 00:27:15,030
+هذه و قلت له arithmetic exception
+
+326
+00:27:15,030 --> 00:27:21,530
+و ديت على الكود هذا شيلت لي try و
+
+327
+00:27:21,530 --> 00:27:29,170
+catch مش هيلزمني ال system أني أستخدم try و catch
+
+328
+00:27:29,170 --> 00:27:33,660
+ليش؟ لأنه أساساالـ class اللي أنا اعتمدت عليه
+
+329
+00:27:33,660 --> 00:27:38,680
+unchecked الـ compiler ماقدرش يفحصه وبالتالي إيش
+
+330
+00:27:38,680 --> 00:27:42,500
+الحالة اللي قدامي إن أعتمد على أي class أعلى منه
+
+331
+00:27:42,500 --> 00:27:46,320
+رتبة العلاقة بينهم is A أو ال class هذا يكون هو ال
+
+332
+00:27:46,320 --> 00:27:49,060
+super تبعه طبعا ال arithmetic حسب الهيراريك اللي
+
+333
+00:27:49,060 --> 00:27:52,620
+احنا شفناها و بنعرفها من ال super تبعه؟ ال
+
+334
+00:27:52,620 --> 00:27:58,280
+exception الارثماتيك
+
+335
+00:28:00,830 --> 00:28:06,750
+Exception السوبر تبعه من الـ runtime أو من الـ
+
+336
+00:28:06,750 --> 00:28:09,930
+exception التانية طبعا هل ممكن أن أروح أستخدم الـ
+
+337
+00:28:09,930 --> 00:28:15,030
+null pointer بدله؟ لأ لأن في الأساس خطأين مختلفين
+
+338
+00:28:15,030 --> 00:28:18,570
+تماما وبالتالي بدك اتراع ال exception بشكل واضح
+
+339
+00:28:18,570 --> 00:28:26,630
+ايش ال exception اللي بتتعامل معاه؟ لأ
+
+340
+00:28:26,630 --> 00:28:35,220
+مش كلهم مش كلهمغالبا .. غالبا كل .. كل العمليات
+
+341
+00:28:35,220 --> 00:28:38,480
+اللي لها أو ال exception اللي لها علاقة بال memory
+
+342
+00:28:38,480 --> 00:28:43,280
+بال file input output أو بال input output كل هذه
+
+343
+00:28:43,280 --> 00:28:47,760
+checked الآن يعني لو أجيت عرفت buffer reader غالبا
+
+344
+00:28:47,760 --> 00:28:51,560
+هيقولك واجفي هذا ممكن يطلع error اتعرفت
+
+345
+00:28:52,960 --> 00:28:55,260
+الله يبقى مصالح على سمحه أي object يتعامل فيه مع
+
+346
+00:28:55,260 --> 00:28:59,380
+ال memory عرفت جربت collector بدك تتحكم بأي حاجة
+
+347
+00:28:59,380 --> 00:29:02,080
+في ال memory هيروح يقولك في عندك هان exception
+
+348
+00:29:02,080 --> 00:29:09,380
+وبالتالي القامش كلهم ممكن احنا ايش نتعامل معاهم as
+
+349
+00:29:09,380 --> 00:29:14,620
+unchecked exceptions طيب ايش ضال عندي هان اليوم
+
+350
+00:29:14,620 --> 00:29:22,280
+عملنا هاي في موضوع الاثراز ممكن انا استخدم اكترمن
+
+351
+00:29:22,280 --> 00:29:26,780
+exception ممكن أستخدم أكتر من exception بس السؤال
+
+352
+00:29:26,780 --> 00:29:30,520
+اللي بيطرح نفسه إذا أنا بدي أعمل rely على ال super
+
+353
+00:29:30,520 --> 00:29:35,760
+class أعمل extend لل super class هل في داعي أني
+
+354
+00:29:35,760 --> 00:29:44,700
+أعدد من ال sub أكيد لأ طيب هذا السؤال مهم الآن لو
+
+355
+00:29:44,700 --> 00:29:50,160
+أنا أجيك و قلتلك تمام أنا هان بعمل extend
+
+356
+00:29:54,230 --> 00:29:59,310
+للـ exception بعمل extend للـ exception هنلزمني
+
+357
+00:29:59,310 --> 00:30:04,530
+أعمل try و catch، مظبوط؟
+
+358
+00:30:04,530 --> 00:30:14,850
+هاي ال try لو
+
+359
+00:30:14,850 --> 00:30:20,290
+أنا عملت arithmetic exception،
+
+360
+00:30:20,290 --> 00:30:26,750
+إيش هيصير في ال code؟أيوة الآن أنا عملت هو قال لي
+
+361
+00:30:26,750 --> 00:30:31,630
+ان هذه ال method هتعمل erase ل exception الآن
+
+362
+00:30:31,630 --> 00:30:35,010
+بتطلع في ال method division غالبا هي arithmetic
+
+363
+00:30:35,010 --> 00:30:38,330
+فانا روح اتكملت ال code تبعي على انه arithmetic
+
+364
+00:30:38,330 --> 00:30:47,310
+exception arithmetic exception وهي
+
+365
+00:30:47,310 --> 00:30:50,870
+قلت له E dot print stack tracer
+
+366
+00:30:53,920 --> 00:31:00,400
+إيش صار عند هان؟ الخطأ بقى موجود لإيش؟ لأن ال
+
+367
+00:31:00,400 --> 00:31:08,640
+method تبع تهان بتعمل throws exception
+
+368
+00:31:08,640 --> 00:31:15,240
+اللي هو ال super class تمام؟ وبالتالي اسم ال class
+
+369
+00:31:15,240 --> 00:31:20,340
+هذا لازم يكون من ضمن ال catch تمام؟ طيب أنا بدي
+
+370
+00:31:20,340 --> 00:31:21,200
+أشرلك التالي
+
+371
+00:31:24,040 --> 00:31:30,220
+أنا راح بضعه بعده بصير؟
+
+372
+00:31:30,220 --> 00:31:35,460
+تمام،
+
+373
+00:31:35,460 --> 00:31:40,540
+زال الخطأ الآن،
+
+374
+00:31:40,540 --> 00:31:46,200
+لو أنا أعملي run كمان مرة، هنا هذه الـ my methods
+
+375
+00:31:46,200 --> 00:31:51,080
+عاملة extend لمين؟ لل exception وفي ال main class
+
+376
+00:31:52,900 --> 00:31:57,480
+عملت two-catch للـ try تبعتي arithmetic في الأول و
+
+377
+00:31:57,480 --> 00:32:02,340
+بعدين exception أنا بدي أنفذ ال code الآن أي
+
+378
+00:32:02,340 --> 00:32:07,320
+exception اللي هيطلع عندك يعني هيك أو بلاش عشان بس
+
+379
+00:32:07,320 --> 00:32:12,920
+نغير هان okay
+
+380
+00:32:12,920 --> 00:32:19,180
+احنا هذه الجملة نوقفها out
+
+381
+00:32:29,130 --> 00:32:40,530
+exception system out exception
+
+382
+00:32:40,530 --> 00:32:49,550
+الآن عند ال output إيش هيطبع؟
+
+383
+00:32:49,550 --> 00:32:52,370
+هيطبع arithmetic
+
+384
+00:32:54,950 --> 00:33:00,950
+exception ولا هيطبع ال close التاني التاني كام
+
+385
+00:33:00,950 --> 00:33:06,770
+واحدة بتقول التاني واحدة تنتين تلاتة اربعة طب كام
+
+386
+00:33:06,770 --> 00:33:11,350
+واحدة بتقول الاول واحدة
+
+387
+00:33:11,350 --> 00:33:17,030
+تنتين تلاتة والباقي ممتنعين عن التصويت طيب خلينا
+
+388
+00:33:17,030 --> 00:33:22,350
+نحللها بشكل منطقي الآن ال exception اللي هيطلع من
+
+389
+00:33:22,350 --> 00:33:30,580
+جملة ال division هذه شو نوعهشو نوعه؟ الـ N، الصبر
+
+390
+00:33:30,580 --> 00:33:34,780
+شوية ال division هي القسمة على صفر إيه نوع ال
+
+391
+00:33:34,780 --> 00:33:40,720
+exception تبعتها؟ arithmetic بيعمل catch هان؟
+
+392
+00:33:40,720 --> 00:33:46,200
+بيعمل catch وبالتالي حتنفذ الجزء الأول صبر عليها
+
+393
+00:33:46,200 --> 00:33:52,700
+شوية ليش الكلام هذا؟ كلمة throws ماغيرت إيش نوع ال
+
+394
+00:33:52,700 --> 00:33:58,850
+exceptionاللي بده يطلع throws كانت فيديوتها واحدة
+
+395
+00:33:58,850 --> 00:34:04,150
+فقط بتقول إن ال method هذه هترمي exception هتطلع
+
+396
+00:34:04,150 --> 00:34:11,470
+exception أنا عملتله throws exception تمام؟ عشان
+
+397
+00:34:11,470 --> 00:34:14,250
+أقول إن هذه بترمي exception اتشكت exception عشان
+
+398
+00:34:14,250 --> 00:34:19,230
+أمسكه طيب لكن هل أنا فعليا بتحكم في نوع ال
+
+399
+00:34:19,230 --> 00:34:23,270
+exception اللي بصير؟ لأ تعالى أورجيكي شغلة في داخل
+
+400
+00:34:23,270 --> 00:34:29,330
+ال div هنافي داخل الـ div بدي
+
+401
+00:34:29,330 --> 00:34:34,910
+أروح هاي home بدي
+
+402
+00:34:34,910 --> 00:34:47,630
+أعرف integer x equal 1 و 2 إيش أنا سويت هان؟ قرر
+
+403
+00:34:47,630 --> 00:35:02,910
+صح؟ طيب، ممتاز أروح تهان و قلتلهX of 2 على الـ B X
+
+404
+00:35:02,910 --> 00:35:11,790
+of 2 على ال B وهي ال main class تبعي run إيش اللي
+
+405
+00:35:11,790 --> 00:35:18,350
+اتنفذ؟ ال exception لأن ال error اللي طلع طلع جاب
+
+406
+00:35:18,350 --> 00:35:23,270
+الجسم على صفر أنا كتبتله كمان مرة X of 2 اللي مش
+
+407
+00:35:23,270 --> 00:35:29,090
+موجودة على صفرفصار في عنده exception وين مفاده؟
+
+408
+00:35:29,090 --> 00:35:34,010
+هان فلما راح ال exception اللي طلع نوعه إيش نوعه؟
+
+409
+00:35:34,010 --> 00:35:40,170
+out of bound هل بيعمل match هان؟ لأ طيب تعالى نشوف
+
+410
+00:35:40,170 --> 00:35:44,890
+هان لو أنا أجيت في لحظة من اللحظات قلتله هى catch
+
+411
+00:35:44,890 --> 00:35:49,490
+لل
+
+412
+00:35:49,490 --> 00:35:52,450
+out of bound
+
+413
+00:35:56,940 --> 00:36:06,820
+out of bound index
+
+414
+00:36:06,820 --> 00:36:12,920
+index out of bound exception ايه؟
+
+415
+00:36:12,920 --> 00:36:22,020
+في عندي system out وده روح اقوله index
+
+416
+00:36:22,020 --> 00:36:23,920
+exception
+
+417
+00:36:26,590 --> 00:36:33,770
+ماذا ستطبع الأن؟ index كمان
+
+418
+00:36:33,770 --> 00:36:39,110
+مرة بنأكد throws لا
+
+419
+00:36:39,110 --> 00:36:45,470
+تؤثر بأي حال من الأحوال في نوع ال exception اللي
+
+420
+00:36:45,470 --> 00:36:52,490
+بنعمله erase فقط بتأثران اعمل catch او لا لل
+
+421
+00:36:52,490 --> 00:36:56,270
+exception اللي موجود عندى هقولنا كمان مرة انه الآن
+
+422
+00:36:56,270 --> 00:36:59,450
+من خلال ال throws انا قاعد بقول ان هذه الجملة ممكن
+
+423
+00:36:59,450 --> 00:37:03,470
+ترمي exception او هذا الخطأ ممكن او هذه الجملة
+
+424
+00:37:03,470 --> 00:37:07,470
+ممكن يصير منها خطأ لكن هل لازم يصير خطأ؟ لأ
+
+425
+00:37:07,470 --> 00:37:11,390
+وبالتالي انا قاعد بقول ان هذه الجملة ممكن تظهر خطأ
+
+426
+00:37:11,390 --> 00:37:15,010
+وبالتالي هستخدم ال throws بعد ال definition او بعد
+
+427
+00:37:15,010 --> 00:37:21,760
+ال parameter تبعت الجملة وقبلالـ body تبعتها لما
+
+428
+00:37:21,760 --> 00:37:23,880
+يكون فيها أنا بدي أعمل list لأكتر من exception
+
+429
+00:37:23,880 --> 00:37:29,840
+بعملهم بعد وبستخدم الكمّة ما بينهم وبالتالي الخطأ
+
+430
+00:37:29,840 --> 00:37:33,900
+ممكن يتم من خلال الاستدعاء للميثود أو خلال ال
+
+431
+00:37:33,900 --> 00:37:38,960
+execution للميثود اللي بده يصير لكن بالمجمل أنا
+
+432
+00:37:38,960 --> 00:37:43,480
+الآن ك programmer أو ك senior developer بصدر بصدر
+
+433
+00:37:43,480 --> 00:37:47,260
+ال exception handing لمن؟للـ client عندى او لـ
+
+434
+00:37:47,260 --> 00:37:50,540
+method caller وبالتالي احنا الآن بنقول احنا ال
+
+435
+00:37:50,540 --> 00:37:54,120
+method أو الخطأ تبعه في المعالي throws الخطأ ممكن
+
+436
+00:37:54,120 --> 00:37:57,000
+يكون اثناء ال execution في ال body تبعتي ال method
+
+437
+00:37:57,000 --> 00:38:00,360
+او عند استدعاء ال method صار في خطأ اما وبالتالي
+
+438
+00:38:00,360 --> 00:38:03,800
+احصل الخطأ اللى موجود عندى هم في الآخر في الآخر
+
+439
+00:38:03,800 --> 00:38:07,860
+انا ك senior programmer او ك senior developer صدرت
+
+440
+00:38:07,860 --> 00:38:12,010
+الخطأ او exception handing لمين؟للـ client أو اللي
+
+441
+00:38:12,010 --> 00:38:15,050
+نسميه الـ method caller اللي هو ال class اللي
+
+442
+00:38:15,050 --> 00:38:17,210
+استدعى ال method تبعتي وعشان هي قبل شوية في ال
+
+443
+00:38:17,210 --> 00:38:22,190
+code استخدمتهم static عشان أسمح لأي class يستدعيهم
+
+444
+00:38:22,190 --> 00:38:26,710
+من برا طيب آخر شغل لو نووحناها أثناء البرنامج قلنا
+
+445
+00:38:26,710 --> 00:38:31,990
+لازم أنا أنتبه أنه لأن بعض ال exception زي ال
+
+446
+00:38:31,990 --> 00:38:35,910
+arithmetic exception مش ضروري أروح أعملها list لأن
+
+447
+00:38:35,910 --> 00:38:38,810
+هي أساسا unchecked
+
+448
+00:38:40,240 --> 00:38:43,840
+الـ exception وبالتالي بقدر أروح أستبدلها بأي
+
+449
+00:38:43,840 --> 00:38:49,180
+exception العلاقة بينهم is A وأفضل واحد هيكون عندي
+
+450
+00:38:49,180 --> 00:38:54,280
+ال exception شوفنا
+
+451
+00:38:54,280 --> 00:38:57,400
+ال code ال structure بيكون بالشكل هذا اشتغلنا
+
+452
+00:38:57,400 --> 00:39:01,640
+عاملين مع بعض وعندي ال calling طيب أخر شغلة عشان
+
+453
+00:39:01,640 --> 00:39:04,660
+ننهي المحاضرة واحنا قلناها أثناء الحديث ال checked
+
+454
+00:39:04,660 --> 00:39:09,620
+exception أو ال behavior تبعت ال Java compilerمع
+
+455
+00:39:09,620 --> 00:39:12,740
+فيما يتعلق في ال exception على نوعين في عند ال
+
+456
+00:39:12,740 --> 00:39:18,920
+checked exception تمام هي exception لكنها
+
+457
+00:39:18,920 --> 00:39:23,640
+مش من ال run-time مش من ال run-time exception
+
+458
+00:39:23,640 --> 00:39:26,980
+وغالبا هذه لها علاقة بال input أو output وليها
+
+459
+00:39:26,980 --> 00:39:32,050
+علاقة بأي axis مع ال memoryالفكرة إن الـ compiler
+
+460
+00:39:32,050 --> 00:39:36,890
+في الـ checked exception إن الـ compiler هيلزم ال
+
+461
+00:39:36,890 --> 00:39:40,950
+programmer إنه يستخدم ال catch ويستخدم ال
+
+462
+00:39:40,950 --> 00:39:44,690
+definition المناسبة للتعامل أو عشان يحل هيك خطأ
+
+463
+00:39:44,690 --> 00:39:48,970
+ممكن يظهر عندنا بينما في ال unchecked هي عبارة عن
+
+464
+00:39:48,970 --> 00:39:54,990
+runtime errorException وبالتالي مثل .. زي ما قلنا
+
+465
+00:39:54,990 --> 00:39:59,550
+ال arithmetic أو ال index out of bound وبالتالي ال
+
+466
+00:39:59,550 --> 00:40:03,090
+system هان مابفحصهاش وممكن يظهر ال exception متى
+
+467
+00:40:03,090 --> 00:40:05,790
+انا ممكن اتعرف على ال exception هتصير ولا مايصيرش
+
+468
+00:40:05,790 --> 00:40:09,530
+اما بالتجربة أثناء ال testing لل applicationأو من
+
+469
+00:40:09,530 --> 00:40:12,010
+خلال الـ experience بكون عارف إن هان ممكن يصير في
+
+470
+00:40:12,010 --> 00:40:16,850
+عندي شغلات لكن غالبا الـ unchecked هذا هدفه أو
+
+471
+00:40:16,850 --> 00:40:20,310
+عفوا بيكون ناتج عن defect أو في خطأ إما في
+
+472
+00:40:20,310 --> 00:40:24,690
+البرنامج ال programmer هذا إيش مانتبهلهوش مثل لما
+
+473
+00:40:24,690 --> 00:40:29,190
+عرفنا integer خمسة
+
+474
+00:40:29,190 --> 00:40:34,770
+تمام؟ وروح قلتله ال A of سبعة أو ستة أو خمسة حتى
+
+475
+00:40:34,770 --> 00:40:40,570
+الآن هذا الخطأولا عمره الـ compiler بيقدر يكتشفه
+
+476
+00:40:40,570 --> 00:40:45,610
+إلا بعد ال run-time وبهيك بنكون إحنا خلصنا ال
+
+477
+00:40:45,610 --> 00:40:49,730
+chapter الأول اللي له علاقة بال exception المحاضرة
+
+478
+00:40:49,730 --> 00:40:51,690
+اللي جاي ان شاء الله تعالى هنبلش في ال graphical
+
+479
+00:40:51,690 --> 00:40:54,470
+user interface في حد عنده أي سؤال يا بنات في ال
+
+480
+00:40:54,470 --> 00:41:01,910
+exception نزلتهم الصبح على الموديل ال basic موجود
+
+481
+00:41:01,910 --> 00:41:05,270
+بالإضافة هذا ال exception الله يعطيكوا العافية يا
+
+482
+00:41:05,270 --> 00:41:05,290
+بنات
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5788a819ae1151208c178431ff210b8f84685229
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU.srt
@@ -0,0 +1,1983 @@
+1
+00:00:01,820 --> 00:00:06,220
+بسم الله الرحمن الرحيم و به نستعين و عليه نتكل و
+
+2
+00:00:06,220 --> 00:00:10,100
+نجمعين اليوم إن شاء الله هنشتغل أو هنتكلم في 
+
+3
+00:00:10,100 --> 00:00:17,980
+المحاضرة رقم 4 اللي بتحكي عن الـ Hemoglobin 
+
+4
+00:00:17,980 --> 00:00:21,120
+synthesis structure and function
+
+5
+00:00:28,590 --> 00:00:32,650
+طيب هذه الصورة بتبين اللي هو الـ structure of
+
+6
+00:00:32,650 --> 00:00:37,150
+Hemoglobin وزي ما أنتم شايفين الـ Hemoglobin
+
+7
+00:00:37,150 --> 00:00:42,230
+بيتكون من two .. four polypeptide chain اثنتين
+
+8
+00:00:42,230 --> 00:00:45,570
+Alpha واثنتين Beta وكل واحدة من الـ polypeptide
+
+9
+00:00:45,570 --> 00:00:52,370
+chain مرتبطة بها جزيء مرتبطة بها جزيء
+
+10
+00:00:52,370 --> 00:00:55,450
+وبالتالي فينا four globin
+
+11
+00:00:57,020 --> 00:01:04,720
+مع four heme و الـ normal hemoglobin بيعتبر هو عبارة
+
+12
+00:01:04,720 --> 00:01:08,180
+عن الـ hemoglobin اللي له two dissimilar globin
+
+13
+00:01:08,180 --> 00:01:14,040
+chain introduction طبعاً الهيموجلوبين هو بروتين كروي أحمر
+
+14
+00:01:14,040 --> 00:01:16,680
+red globular protein which have molecular weight
+
+15
+00:01:16,680 --> 00:01:23,220
+64500 الهيموجلوبين بيشكل ثلث وزن الخلية ووظيفته 
+
+16
+00:01:23,220 --> 00:01:26,640
+الأساسية هي نقل الأكسجين من الـ lung للـ tissue
+
+17
+00:01:26,640 --> 00:01:31,000
+واللي اليوم نعرف حوالي أكثر من 500 different
+
+18
+00:01:31,000 --> 00:01:35,600
+hemoglobin variant كلهم لهم نفس الـ structure لكن 
+
+19
+00:01:35,600 --> 00:01:38,960
+اللي بدنا نأخذه في عين الاعتبار أنه الـ normal
+
+20
+00:01:38,960 --> 00:01:43,530
+hemoglobinnormal functioning hemoglobin هو عبارة 
+
+21
+00:01:43,530 --> 00:01:47,010
+عن الـ hemoglobin اللي بيحتوي أو بيتكون من two
+
+22
+00:01:47,010 --> 00:01:52,210
+pairs of dissimilar globin chain نبدأ بالـ
+
+23
+00:01:52,210 --> 00:01:57,810
+hemoglobin synthesis أول جزء من المحاضرة وطبعاً
+
+24
+00:01:57,810 --> 00:02:00,830
+كلكم بتعرفوا أن الـ hemoglobin بيتكون من hemoglobin
+
+25
+00:02:00,830 --> 00:02:06,790
+وكل واحد بيتصنع في منطقة أو في آلة واحدة في
+
+26
+00:02:06,790 --> 00:02:15,360
+developing RBCsdeveloping red cell precursor وعشان 
+
+27
+00:02:15,360 --> 00:02:21,580
+يطلع الـ hemoglobin بكمياته الطبيعية لابد من أن
+
+28
+00:02:21,580 --> 00:02:28,440
+يكون في Coordination يعني توازي في الـ hemoglobin
+
+29
+00:02:28,440 --> 00:02:33,720
+assembly hemoglobin assembly
+
+30
+00:02:38,880 --> 00:02:44,920
+تبدأ بالـ Heme Synthesis وهو كما تشاهدون في الفيجر
+
+31
+00:02:44,920 --> 00:02:52,320
+يمثل خطوات الـ Heme Synthesis ويبدأ أول خطواته رقم
+
+32
+00:02:52,320 --> 00:02:57,440
+1,2,3,4 بالأحمر لغاية سبعة خطوات يبدأ في الميتوكندرية
+
+33
+00:02:57,440 --> 00:03:02,590
+هذه عبارة عن الخلية الدائرة اللي في النص هي
+
+34
+00:03:02,590 --> 00:03:05,510
+عبارة عن ميتوكندرية وبره هي عبارة عن الـ cytoplasm
+
+35
+00:03:05,510 --> 00:03:10,310
+فالخطوات اللي هي مبتدأة في الميتوكندرية لأنها أول 
+
+36
+00:03:10,310 --> 00:03:13,990
+خطوة هي عبارة عن energy dependent process أو step
+
+37
+00:03:13,990 --> 00:03:18,370
+وبالتالي بدها ياش بدها تكون في الميتوكندرية فهي
+
+38
+00:03:18,370 --> 00:03:22,250
+عبارة عن Succinyl Coenzyme A مع Glycine بدينا Delta
+
+39
+00:03:22,250 --> 00:03:27,070
+-Amino-Levulinic Acid خطوة بتعتبر rate limiting
+
+40
+00:03:27,070 --> 00:03:33,070
+steps ومن خلالها نقدر نعمل Control كل العملية بتزيد
+
+41
+00:03:33,070 --> 00:03:45,250
+إذا كان فيه Iron كثير وبتقل
+
+42
+00:03:45,250 --> 00:03:53,110
+يوم ما يكون فيه Heme كثير إذا زاد الـ Heme بتقل هذه 
+
+43
+00:03:53,110 --> 00:03:57,690
+العملية وهكذا بتعتبر rate limiting steps خلّينا
+
+44
+00:03:57,690 --> 00:04:03,750
+نشوفها دي هي عبارة عن Succinyl Coenzyme A على Delta
+
+45
+00:04:03,750 --> 00:04:06,830
+Aminolevulinate Synthetase خطوة ثانية اثنين منه بيطلع على الـ
+
+46
+00:04:06,830 --> 00:04:10,290
+سايتوبلازم واثنين منه بيكونوا الـ porphobilinogen
+
+47
+00:04:10,290 --> 00:04:13,690
+اللي بتحول اليورو porphobilinogen
+
+48
+00:04:13,690 --> 00:04:17,630
+ثلاثة ثم كوبرو porphobilinogen ثلاثة اللي 
+
+49
+00:04:17,630 --> 00:04:20,410
+برجع مرة ثانية by unknown ميكانيزم على الـ
+
+50
+00:04:20,410 --> 00:04:25,610
+mitochondria وهناك بتحول لـ Protoporphyrin تسعة اللي
+
+51
+00:04:25,610 --> 00:04:29,050
+بتحول لـ Protoporphyrin تسعة اللي في النهاية بيخش الـ
+
+52
+00:04:29,050 --> 00:04:34,200
+Iron على في نص الجزيء بيكون الـ Heme ونبدأ نشوف
+
+53
+00:04:34,200 --> 00:04:42,340
+واحدة واحدة هذه الخطوات هذه
+
+54
+00:04:42,340 --> 00:04:46,780
+أول خطوة Succinyl Coenzyme A مع Glycine Delta Amino
+
+55
+00:04:46,780 --> 00:04:50,920
+Levulinic Acid Synthetase Enzyme بيدينا Delta Amino
+
+56
+00:04:50,920 --> 00:04:57,220
+Levulinic Acid أو الـ Levulinate في النهاية هذه إيه؟ زي
+
+57
+00:04:57,220 --> 00:05:03,180
+ما قلت لكم Energy Dependent والإنزيم
+
+58
+00:05:03,180 --> 00:05:07,160
+Delta Aminolevulinate Synthetase هو المسؤول عنها تعتبر 
+
+59
+00:05:07,160 --> 00:05:12,360
+فيها limiting steps في تصنيع الـ Heme وغالباً
+
+60
+00:05:12,360 --> 00:05:15,600
+stimulated in the presence of globin آسف و
+
+61
+00:05:15,600 --> 00:05:20,580
+inhibited in the presence of free heme تعتبر 
+
+62
+00:05:20,580 --> 00:05:24,500
+Control هذه الخطوة Control mechanism وبتحتاج إلى 
+
+63
+00:05:24,500 --> 00:05:28,720
+عدة عوامل منها Vitamin B6 في الرأس وCopper ion
+
+64
+00:05:30,020 --> 00:05:34,760
+والـ Synthesis of Delta Aminolevulinic Acid Synthetase
+
+65
+00:05:34,760 --> 00:05:38,520
+is also inhibited in the presence of free heme
+
+66
+00:05:38,520 --> 00:05:44,700
+يعني كمان الإنزيم بيهبط ودي بتعتبر فيرثال اللي هو
+
+67
+00:05:44,700 --> 00:05:48,560
+Feedback Inhibition Mechanism بقى الهبوط دايركت
+
+68
+00:05:48,560 --> 00:05:52,980
+ماركوتو جزيء of Delta Aminolevulinic Acid are
+
+69
+00:05:52,980 --> 00:05:54,320
+Dimerized
+
+70
+00:05:57,010 --> 00:06:08,250
+في وجود دلتا أمينو أو دلتا أمينو ديهيدراتيز أو
+
+71
+00:06:08,250 --> 00:06:14,510
+بيسموه الـ Porphobilinogen سينتيز تمام أنه
+
+72
+00:06:14,510 --> 00:06:20,430
+دياميرايز وبيكونوا الـ Porphobilinogen والـ next
+
+73
+00:06:20,430 --> 00:06:24,250
+step هي تكوين الـ Porphyrin ring والـ Porphyrin
+
+74
+00:06:24,250 --> 00:06:30,970
+ring هي one ringone unit of pyrrole ring وزي ما أنتم
+
+75
+00:06:30,970 --> 00:06:36,070
+شايفين بيتكون الـ uroporphyrinogen ثلاثة معايا
+
+76
+00:06:36,070 --> 00:06:42,670
+اللي بيصله Decarboxylase Decarboxylation by
+
+77
+00:06:42,670 --> 00:06:47,610
+Decarboxylase enzyme إلى coproporphyrinogen ثلاثة
+
+78
+00:06:47,610 --> 00:06:51,530
+وبعد
+
+79
+00:06:51,530 --> 00:06:57,620
+هيك الـ coproporphyrinogen ثلاثة بيصير بيكون أكسيديز 
+
+80
+00:06:57,620 --> 00:07:03,720
+إنزيم بيتحول لـ Protoporphyrin 9 في الميتوكندرية
+
+81
+00:07:03,720 --> 00:07:07,660
+يعني بيخش مرة ثانية عن الميتوكندرية والـ
+
+82
+00:07:07,660 --> 00:07:14,860
+Protoporphyrin 9 بيتحول بيض وايضاً بيكون أكسيديز إنزيم
+
+83
+00:07:14,860 --> 00:07:18,080
+إلى Protoporphyrin 9 وهي يصير الـ four parallel ring
+
+84
+00:07:18,080 --> 00:07:24,220
+تكوين ثم بعد ذلك لم يبقى إلا إلى ذرة الحديد أن
+
+85
+00:07:24,220 --> 00:07:29,630
+تخش في النص الـ Protoporphyrin 9 في نص الجزيء بيكون
+
+86
+00:07:29,630 --> 00:07:35,250
+نقاش الـ Heme الإنزيم المسؤول عن هذه العملية هو
+
+87
+00:07:35,250 --> 00:07:39,550
+الـ Ferrochelatase إنزيم التالي إحنا مرينا عليه في
+
+88
+00:07:39,550 --> 00:07:45,270
+الـ .. في الـ Sideroblastic Anemia إذا فاكرين هو والـ 
+
+89
+00:07:45,270 --> 00:07:48,770
+Delta Aminolevulinic Acid Synthetase اثنين إنزيم
+
+90
+00:07:48,770 --> 00:07:52,790
+مسؤولين عن اللي هو تصنيع الـ Heme
+
+91
+00:07:56,410 --> 00:08:00,290
+Globin Synthesis الثاني اللي هو جزء الثاني من الـ
+
+92
+00:08:00,290 --> 00:08:04,330
+Hemoglobin قالوا هذا Globin يعني جزء من البروتين 
+
+93
+00:08:04,330 --> 00:08:08,090
+يعني اللي مسؤول عنه تصنيع عن تصنيعه جينات قالوا 
+
+94
+00:08:08,090 --> 00:08:11,950
+غالباً في عندنا ثمانية functional Globin gene
+
+95
+00:08:11,950 --> 00:08:19,250
+مسؤولين عن تصنيع two-duplicate Globin molecule
+
+96
+00:08:19,250 --> 00:08:26,070
+موجودين in two-duplicate جيني cluster بيتا لايك
+
+97
+00:08:26,070 --> 00:08:29,550
+والألفا لايك الـ Beta like الـ cluster موجودة على
+
+98
+00:08:29,550 --> 00:08:36,090
+كروموسوم 11 والألفا لايك على كروموسوم 16 الثمانية جينات
+
+99
+00:08:36,090 --> 00:08:40,850
+هدول مسؤولين عن تصنيع ستة أنواع من الـ globin chain
+
+100
+00:08:40,850 --> 00:08:46,130
+أو polypeptide اللي هم ألفا وبيتا وجاما ودلتا
+
+101
+00:08:46,130 --> 00:08:52,280
+وإبسيلون وزيتا كيف يتم الـ ontogeny of globin tree
+
+102
+00:08:52,280 --> 00:08:57,240
+synthesis وهذه مهمة صحية طبعاً بيتم تصنيع الجلوبين
+
+103
+00:08:57,240 --> 00:09:08,320
+حسب اللي هو المراحل اللي بتمر فيها الجنين
+
+104
+00:09:09,330 --> 00:09:13,690
+يعني حسب مراحل تكوين الإنسان ففي الجنين على سبيل 
+
+105
+00:09:13,690 --> 00:09:19,170
+المثال أول مراحل تكوينه تبدأ في الـ yolk sac at two to
+
+106
+00:09:19,170 --> 00:09:23,930
+three weeks of gestation أول ما يبدأ يتصنع إلى الـ
+
+107
+00:09:23,930 --> 00:09:27,790
+زيتا والإبسيلون Globin chain ويكونوا الاثنين مع بعض
+
+108
+00:09:27,790 --> 00:09:33,230
+Hemoglobin اسمه Gower-1 زيتا إبسيلون كوربتو وby
+
+109
+00:09:33,230 --> 00:09:36,630
+five weeks of gestation أيضاً في الـ yolk sac الجامع
+
+110
+00:09:36,630 --> 00:09:41,870
+والألفا تبدأ تتصنع ويصير عندنا أربعة Globin chain
+
+111
+00:09:41,870 --> 00:09:46,510
+بتوافق والتباديل بيعملولنا كمان اثنين Hemoglobin
+
+112
+00:09:46,510 --> 00:09:50,510
+واحد اسمه Portland والثاني Gower-2 وبالتالي بيصير
+
+113
+00:09:50,510 --> 00:09:55,090
+عندنا ثلاثة أنواع من الـ Hemoglobin Portland زيتا
+
+114
+00:09:55,090 --> 00:10:00,890
+جامعة الكوربتو وجاور اللي هو two هو عبارة عن Alpha
+
+115
+00:10:00,890 --> 00:10:07,540
+Epsilon كوربتو طبعاً بيبدأ زيادة الجامع والألف على
+
+116
+00:10:07,540 --> 00:10:12,620
+حساب زيتا وإبسيلون نصل لمرحلة بيبدأ دور الـ Liver
+
+117
+00:10:12,620 --> 00:10:19,420
+وكل اللي بيتصنع هو Alpha Gamma وبتبدأ الـ Beta ثم 
+
+118
+00:10:19,420 --> 00:10:23,800
+تليها الـ Delta في التصنيع ففي الـ liver من ستة
+
+119
+00:10:23,800 --> 00:10:27,740
+لتلاتين weeks الـ main Hemoglobin اللي بيتصنع هو
+
+120
+00:10:27,740 --> 00:10:33,240
+Alpha Gamma Two ولما تبدأ تتصنع الـ Delta جزء منها
+
+121
+00:10:33,240 --> 00:10:39,400
+بيصنع لنا Alpha Delta 2 Hemoglobin A2 وبعد ذلك 
+
+122
+00:10:39,400 --> 00:10:47,700
+بعد الولادة الـ bone marrow هو الأساس في تصنيع الـ RBC's
+
+123
+00:10:47,700 --> 00:10:52,500
+أو الـ Hemopoiesis ودم الـ Hemoglobin الأساسي في هذا
+
+124
+00:10:52,500 --> 00:10:58,640
+الحالة بيكون Hemoglobin A وهو Alpha Beta 2 وهذا
+
+125
+00:10:58,640 --> 00:11:04,260
+عبارة عن الـ switching of hemoglobin في المراحل 
+
+126
+00:11:04,260 --> 00:11:11,660
+المختلفة تبعت اللي هو الـ embryonic life وبعدها في 
+
+127
+00:11:11,660 --> 00:11:16,220
+الـ neonatal life ففي الـ embryonic ده هو جوهر واحد 
+
+128
+00:11:16,220 --> 00:11:20,800
+نقول Portland جوهر two y, z, وإبسيلون أي شيء
+
+129
+00:11:20,800 --> 00:11:27,200
+بتكونوا embryo في الـ fetus بعد هيك بتبدأ الألفا
+
+130
+00:11:27,200 --> 00:11:33,070
+والجامع وبدو يزيدوا على حساب ياش الزيتا والإبسيلون
+
+131
+00:11:33,070 --> 00:11:36,430
+وفي هذه الحالة بيكون الـ liver هو الأساس والـ major
+
+132
+00:11:36,430 --> 00:11:40,470
+hemoglobin هو الـ Hemoglobin F وإذا دخلت ثالثة آدي 
+
+133
+00:11:40,470 --> 00:11:48,970
+على الخط بيصير Hemoglobin A2 على اللي بتصنع بعد
+
+134
+00:11:48,970 --> 00:11:54,510
+هيك الـ bone marrow هو الأساس في كل تصنيع الـ Hemoglobin
+
+135
+00:11:54,510 --> 00:11:58,380
+وزي ما أنتم شايفين الـ alpha والـ beta هي الأساس و
+
+136
+00:11:58,380 --> 00:12:06,220
+هناك قليل من Gamma طبعاً 
+
+137
+00:12:06,220 --> 00:12:09,520
+هذه الـ switching phenomena اللي بتصير دي هي أول 
+
+138
+00:12:09,520 --> 00:12:14,360
+شيء بيكون في زيتا تبدأ تزيد Alpha على حساب زيتا و
+
+139
+00:12:14,360 --> 00:12:20,800
+أنا ببدأ اللي هو يزيد Gamma على حساب إبسيلون فتنزل
+
+140
+00:12:20,800 --> 00:12:28,110
+الإبسيلون وبتزيد Gamma بعد الحل للولادة بيصير يعني 
+
+141
+00:12:28,110 --> 00:12:39,250
+after birth بيصير الـ beta و الـ alpha هي الأساس اه
+
+142
+00:12:39,250 --> 00:12:44,730
+sorry الـ beta بتزيد على حساب الـ gamma ده هي فكله
+
+143
+00:12:44,730 --> 00:12:49,470
+بيصير الـ alpha و الـ beta أَدلّ الهيموجلوبين في النهاية
+
+144
+00:12:49,470 --> 00:12:53,490
+بيكون عبارة عن مرمى، أَدلّ الهيموجلوبين بيكون عبارة
+
+145
+00:12:53,490 --> 00:12:59,970
+عن الـ hemoglobin A Alpha 2 Beta 2 96-98% و A2 Alpha
+
+146
+00:12:59,970 --> 00:13:04,750
+2 Delta الكل 2 و نص، واحد و نص لتلاتة، و 2، و ده
+
+147
+00:13:04,750 --> 00:13:08,010
+مهم جدا لتحديد أنواع مغينة من القديمة بالذات
+
+148
+00:13:08,010 --> 00:13:13,350
+الثلاثينية فهو الـ hemoglobin F وهو Alpha 2 Gamma 2 وهو 
+
+149
+00:13:13,350 --> 00:13:16,250
+أقل من واحد في المية point five to point eight
+
+150
+00:13:16,250 --> 00:13:21,340
+percentage وهذا الـ Global Synthesis قلنا على two
+
+151
+00:13:21,340 --> 00:13:25,620
+gene cluster واحد اللي هو كروموزوم رقم 11 والتاني 16
+
+152
+00:13:25,620 --> 00:13:29,620
+الكروموزوم رقم 11 موجود عليه الـ beta-like gene
+
+153
+00:13:29,620 --> 00:13:33,320
+cluster وزي ما تشوفين فينا Beta gene Delta gene
+
+154
+00:13:33,320 --> 00:13:37,780
+Gamma gene و Epsilon يعني أربع أنواع من إيه الشيء
+
+155
+00:13:37,780 --> 00:13:42,680
+الجينات الجامعة هن في عندنا نوعين بيختلفوا فقط في
+
+156
+00:13:42,680 --> 00:13:47,220
+أمينو أسيد واحد وهو الـ G والـ A الالنين والعيسين في
+
+157
+00:13:47,220 --> 00:13:50,780
+رقم
+
+158
+00:13:50,780 --> 00:13:57,660
+145 أمينو أسيد بينما
+
+159
+00:13:57,660 --> 00:14:03,800
+الـ Alpha Globin gene cluster موجودة على كروموزوم رقم
+
+160
+00:14:03,800 --> 00:14:08,320
+16 وزي ما تشوفون في عندنا زيتا نوعين they are
+
+161
+00:14:08,320 --> 00:14:11,530
+similar و Alpha نوعين يعني two types of globin
+
+162
+00:14:11,530 --> 00:14:17,130
+بيتصنعوا اثنين نفس الكمية ونفس النوع من Alpha
+
+163
+00:14:17,130 --> 00:14:24,510
+وبنوع الـ hemoglobin المختلفة وما يدخل في تركيبها
+
+164
+00:14:24,510 --> 00:14:31,850
+Structure الـ structure بيتكوّن
+
+165
+00:14:31,850 --> 00:14:34,510
+من أربع أشكال primary و secondary و tertiary و
+
+166
+00:14:34,510 --> 00:14:37,790
+quaternary الـ primary بيعتمد على
+
+167
+00:14:43,950 --> 00:14:48,010
+الله أبو صلى الله عليه و سلم و محمد الـ primary
+
+168
+00:14:48,010 --> 00:14:49,650
+structure of the globin reflected in the amino
+
+169
+00:14:49,650 --> 00:14:54,330
+acid sequence of the various chains أمينو أسل
+
+170
+00:14:54,330 --> 00:15:00,010
+سيكوانس يعني فقط بنعد واحد ورا التاني ماشي بينما
+
+171
+00:15:00,010 --> 00:15:06,030
+الـ secondary يبقى تكوّن من 9 non helical joined
+
+172
+00:15:06,030 --> 00:15:12,550
+with 8 helical الـ Helical بيعطوهم
+
+173
+00:15:12,550 --> 00:15:19,030
+أرقام A,B,C بينما الـ Non-helical هو عبارة عن يعني
+
+174
+00:15:19,030 --> 00:15:24,770
+وصلة ما بين two helical فبتاخد الرقمين قبل
+
+175
+00:15:24,770 --> 00:15:27,990
+واللي بعد يعني الـ helical اللي قبلها و الـ helical
+
+176
+00:15:27,990 --> 00:15:31,630
+اللي بعدها فبتصير لنا مثلًا على سبيل المثال الـ
+
+177
+00:15:31,630 --> 00:15:37,490
+Non-helical الأولى هي A B وهي ما بين الـ helix A و
+
+178
+00:15:37,490 --> 00:15:41,690
+الـ helix B وهذا هو مصمم الـ helix الـ helix الـ helix
+
+179
+00:15:41,690 --> 00:15:45,170
+الـ helix الـ helix الـ helix الـ helix الـ helix
+
+180
+00:15:45,170 --> 00:15:46,970
+الـ helix الـ helix الـ helix الـ helix الـ helix
+
+181
+00:15:46,970 --> 00:15:47,350
+الـ helix الـ helix الـ helix الـ helix الـ helix
+
+182
+00:15:47,350 --> 00:15:48,570
+الـ helix الـ helix الـ helix الـ helix الـ helix
+
+183
+00:15:48,570 --> 00:15:54,850
+الـ helix
+
+184
+00:15:54,850 --> 00:16:00,130
+الـ helix الـ helix الـ helix الـ helix الـ helix
+
+185
+00:16:00,130 --> 00:16:04,500
+الـ helix الـ helix الـ helix الـ helix مجلبة تأخذ
+
+186
+00:16:04,500 --> 00:16:14,160
+شكل الـ Sphere وبيتكلم عن Intramolecular Bonds هي
+
+187
+00:16:14,160 --> 00:16:18,780
+المسؤولة عن الـ helical part وهي مسؤولة عن الـ
+
+188
+00:16:18,780 --> 00:16:25,500
+agility of the molecule و بتؤدي إلى تصميم أنها
+
+189
+00:16:25,500 --> 00:16:29,520
+نهرك وجالوا في الـ tertiary في ثلاث مناطق مهمة جدا
+
+190
+00:16:29,520 --> 00:16:33,520
+ثلاث characteristic feature sorry مهمة جدا أما واحد
+
+191
+00:16:33,520 --> 00:16:42,580
+أن الـ polar or chart side الـ chain بتكون برا وهذه
+
+192
+00:16:42,580 --> 00:16:50,480
+بتؤكد على أنه على أن الموليكيول هيدروفوبك وبالتالي
+
+193
+00:16:50,480 --> 00:16:57,940
+صليبل بينما الـ non polar بتكون روابط داخلية وهذا
+
+194
+00:16:57,940 --> 00:17:02,900
+يعني على أن الموليكيول من جوا هو هيدروفوبك ما بده
+
+195
+00:17:02,900 --> 00:17:06,980
+ماء تخش جوا وبالتالي بدهش يتأكسد من جوا
+
+196
+00:17:11,030 --> 00:17:15,510
+الـ Heme Bucket is created بيصير فيه Opened Top
+
+197
+00:17:15,510 --> 00:17:21,610
+Left للموليكيول بنفتح من هنا وبيصير فيه إيش الـ
+
+198
+00:17:21,610 --> 00:17:24,890
+Heme Bucket due بالهيم موجودة في الـ Tertiary
+
+199
+00:17:24,890 --> 00:17:31,590
+Structure وطبعا الـ Due بالهيم موجودة عشان شغلتين
+
+200
+00:17:31,590 --> 00:17:38,510
+شغلة أولانية عشان تحمل الـ Oxygen في جواتها نمرا
+
+201
+00:17:38,510 --> 00:17:43,540
+اثنين عشان تتضمنتحت حماية الـ Ferrous-Ion اللي
+
+202
+00:17:43,540 --> 00:17:48,420
+موجودة في داخل الـ Globin. نبغى تلاتة الـ Amino Acid
+
+203
+00:17:48,420 --> 00:17:56,180
+اللي موجود سواء كان Inter-Subunit Bonding مسؤول عن
+
+204
+00:17:56,180 --> 00:18:00,020
+الـ Quaternary Structure اللي بدأت تكون بعد ذلك
+
+205
+00:18:00,020 --> 00:18:05,320
+وهذا الـ Quaternary Structure والـ Quaternary
+
+206
+00:18:05,320 --> 00:18:11,750
+Structure of Hemoglobin له أربع Subunits مرتبة في
+
+207
+00:18:11,750 --> 00:18:17,550
+الـ hemoglobin A بشكل رباعي المراوحة بتتكون روابط
+
+208
+00:18:17,550 --> 00:18:22,810
+Alpha 1 Beta 1 أو Alpha 2 Beta 2 وهذه روابط قوية
+
+209
+00:18:22,810 --> 00:18:28,470
+مسؤولة عن stability of the molecule بتشكل حوالي
+
+210
+00:18:28,470 --> 00:18:32,910
+تشترك في تكوينها حوالي 30 amino acids بينما الروابط
+
+211
+00:18:32,910 --> 00:18:37,370
+الثانية Alpha-1 Beta-2 Alpha-2 Beta-1 وهذه تقوم
+
+212
+00:18:37,370 --> 00:18:41,290
+بإعادة الـ Solubility روابط الامينواسد التي تشترك
+
+213
+00:18:41,290 --> 00:18:44,710
+فيها حوالي عشرين أمينواسد وأخر واحدة Alpha-1
+
+214
+00:18:44,710 --> 00:18:49,230
+ب Alpha-2 Beta-1 Beta-2 وهذه أضعفهم، أضعف الروابط
+
+215
+00:18:49,230 --> 00:18:52,670
+لأنها مسؤولة عن تعمل الـ Oxygenation و Deoxygenation
+
+216
+00:18:52,670 --> 00:18:59,050
+وبالتالي مقموض منها أنها تفتح وتتسكر Function of
+
+217
+00:18:59,050 --> 00:19:04,640
+Hemoglobin بتعرف أن Oxygen delivery to the tissue
+
+218
+00:19:04,640 --> 00:19:10,000
+وطبيعة التفاعل ما بين الـ Hemoglobin و الـ Oxygen
+
+219
+00:19:10,000 --> 00:19:14,300
+بيعتمد على الـ Oxygen نفسي Oxygenation وليس
+
+220
+00:19:14,300 --> 00:19:18,140
+Oxidation Oxygenation يعني حمل الاكسجين وليس
+
+221
+00:19:18,140 --> 00:19:24,230
+أكسدة الـ Hemoglobin يعني مش تفاعل كيميائي مرة
+
+222
+00:19:24,230 --> 00:19:28,810
+اثنين كل لن هيموجلوبين برتبط بأربع ذرات من
+
+223
+00:19:28,810 --> 00:19:35,530
+الأكسجين، نمرة تلاتة عملية الـ Oxygenation لا تتعدى
+
+224
+00:19:35,530 --> 00:19:41,050
+الـ point O one second يعني بس يخش الـ hemoglobin على
+
+225
+00:19:41,050 --> 00:19:45,690
+الـ لان يصير فيه Oxygenation للهيموجلوبين عملية الـ
+
+226
+00:19:45,690 --> 00:19:48,190
+Oxygenation بتتم من خلال تباعد
+
+227
+00:19:50,490 --> 00:19:53,890
+حركة الموليكيوسوري وجدوا أنه يوم ما يصير فيه
+
+228
+00:19:53,890 --> 00:20:00,170
+Oxygenation بيصير فيه Beta Chain Closing يعني الـ
+
+229
+00:20:00,170 --> 00:20:04,670
+Beta Chain بتقرب على بعض ويوم ما تقرب على بعض الـ
+
+230
+00:20:04,670 --> 00:20:10,130
+heme pocket مفتوحة فبتخش الـ Oxygen في داخل الـ heme يوم
+
+231
+00:20:10,130 --> 00:20:16,330
+ما تبعد الـ Beta Chain عن بعض ماشي أرض أرض يعني
+
+232
+00:20:16,870 --> 00:20:21,610
+بيصير فيه ضغط على الـ hem pocket فبتطلع الـ oxygen
+
+233
+00:20:21,610 --> 00:20:26,050
+اللي في جلبها عشان هيك بيصير في oxygen unloading
+
+234
+00:20:26,050 --> 00:20:30,650
+وفي نفس الوقت في مركب اسمه 2,3-DPG
+
+235
+00:20:30,650 --> 00:20:36,030
+2,3-diphosphoglycerate هو اللي بيدخل في داخل الـ
+
+236
+00:20:36,030 --> 00:20:41,430
+hemoglobin موليكيول وبالتالي بيعتبر الـ 2,3-DPG منافس
+
+237
+00:20:41,430 --> 00:20:49,700
+للأكسجين في دخوله
+
+238
+00:20:49,700 --> 00:20:55,000
+إلى الـ Hemoglobin أو تحميل الـ Hemoglobin فهذه
+
+239
+00:20:55,000 --> 00:20:59,380
+الصورة كما تشاهدون هي الـ Hembucket فاتحة فالـ
+
+240
+00:20:59,380 --> 00:21:06,380
+Oxygen داخلها وهذا معناه أن الـ Beta Chain قربت
+
+241
+00:21:06,380 --> 00:21:10,020
+على بعض سكرت
+
+242
+00:21:10,020 --> 00:21:11,740
+يعني ففتحت الـ Hembucket
+
+243
+00:21:18,430 --> 00:21:25,110
+الـ Hembucket تباعدت عن بعضها تباعدت عن بعضها تباعدت عن
+
+244
+00:21:25,110 --> 00:21:32,010
+بعضها تباعدت عن بعضها تباعدت عن بعضها تباعدت عن بعضها
+
+245
+00:21:32,010 --> 00:21:33,970
+بعضها تباعدت عن بعضها تباعدت عن بعضها تباعدت عن بعضها
+
+246
+00:21:33,970 --> 00:21:36,110
+بعضها تباعدت عن بعضها تباعدت عن بعضها تباعدت عن بعضها
+
+247
+00:21:36,110 --> 00:21:40,940
+تباعدت عن بعضها تب..مشي طلعت فضت الجوايه الجيوب الـ
+
+248
+00:21:40,940 --> 00:21:45,800
+oxygen اللي في جلبها ومين دخل دخل 2,3-DPG في النص
+
+249
+00:21:45,800 --> 00:21:53,280
+صار الـ hemoglobin دي oxygenated معروف
+
+250
+00:21:53,280 --> 00:21:58,780
+أن الـ normal hemoglobin في كل جرام منه بيرتبط بـ 1
+
+251
+00:21:58,780 --> 00:22:03,940
+.34 مل من الـ oxygen يعني واحد عنده hemoglobin 14
+
+252
+00:22:03,940 --> 00:22:09,950
+جرام تقريبا بيحمل 20 مل من الأكسجين 20 مل من
+
+253
+00:22:09,950 --> 00:22:13,590
+الـ .. بتحمل بـ 20 مل من الأكسجين تقريبا 19
+
+254
+00:22:13,590 --> 00:22:18,270
+نص لأنه ما بيصيرش complete اللي هو loading
+
+255
+00:22:18,270 --> 00:22:23,670
+للأكسجين الـ degree of saturation تعتمد على الـ
+
+256
+00:22:23,670 --> 00:22:30,070
+oxygen tension وكلنا بنعرف أن ضغط الأكسجين في الـ
+
+257
+00:22:30,070 --> 00:22:34,450
+lung حوالي 100 ملي متر زئبق بينما في الـ tissue
+
+258
+00:22:35,150 --> 00:22:38,750
+حوالي 35 ملي متر زئبق فالفرق في
+
+259
+00:22:38,750 --> 00:22:42,990
+الضغط بحد ذاته كمان هو عامل من العوامل أنه يصير
+
+260
+00:22:42,990 --> 00:22:48,930
+عملية تعبئة أو تفريغ للـ Hemoglobin العملية هذه
+
+261
+00:22:48,930 --> 00:22:54,410
+مثلوها رياضيا الـ curve سموه oxygen dissociation
+
+262
+00:22:54,410 --> 00:22:59,730
+curve of Hemoglobin وقالوا أن من صفاته
+
+263
+00:23:02,260 --> 00:23:05,880
+أنه بيعكس الـ properties of hemoglobin itself
+
+264
+00:23:05,880 --> 00:23:15,160
+وقالوا أنه بيتأثر بعوامل عدة هذه العوامل لا تؤثر
+
+265
+00:23:15,160 --> 00:23:19,980
+على شكل الـ curve وإنما تؤثر على موقع الـ curve
+
+266
+00:23:19,980 --> 00:23:27,460
+فبتحرك الـ curve إما يمينا وإما يسارا طبعا هي وكما
+
+267
+00:23:27,460 --> 00:23:30,180
+تشوفون العلاقة ما بين الـ lung و الـ tissue في الـ
+
+268
+00:23:30,180 --> 00:23:35,160
+lung ده هوبتحمل الـ hemoglobin بالأكسجين ولما بيروح
+
+269
+00:23:35,160 --> 00:23:38,560
+اتشه بيصير فيه release للـ hemoglobin للأكسجين من
+
+270
+00:23:38,560 --> 00:23:42,080
+الـ hemoglobin ومش بس release بتحمل ثاني أكسي
+
+271
+00:23:42,080 --> 00:23:44,640
+الكربون برجع تاني على الـ lung وهناك بيصير فيه
+
+272
+00:23:44,640 --> 00:23:50,780
+release للـ CO2 to the lung وهي الـ normal
+
+273
+00:23:50,780 --> 00:23:53,800
+hemoglobin oxygen dissociation curve اللي هو
+
+274
+00:23:53,800 --> 00:23:57,720
+الأزرق هذا اللي في النص وقلنا في بعض العوامل
+
+275
+00:23:57,720 --> 00:24:02,380
+اللي بتؤثر على موقع الـ curve فإما يأتي على اليمين
+
+276
+00:24:02,380 --> 00:24:07,460
+أو يذهب إلى الشمال لكن شكل الـ curve يبقى كما هو فإما
+
+277
+00:24:07,460 --> 00:24:14,020
+يصبح الـ hemoglobin right shifted أو left shifted بس
+
+278
+00:24:14,020 --> 00:24:20,220
+يجب أن نأخذ في هذا الاعتبار أنه عند 50% تقريبا أو
+
+279
+00:24:20,220 --> 00:24:26,060
+40% الـ hemoglobin
+
+280
+00:24:26,060 --> 00:24:27,500
+تشوفوا لحظة
+
+281
+00:24:30,380 --> 00:24:34,380
+الضغط الأكسجين 40% اللي هو في ال tissue بيكون ال
+
+282
+00:24:34,380 --> 00:24:42,040
+Hemoglobin محمل فقط ب 75% من ال oxygen وطب البذل
+
+283
+00:24:42,040 --> 00:24:45,460
+راح في ال tissue صار releasing في ال tissue ففي كل
+
+284
+00:24:45,460 --> 00:24:52,260
+مرة ال Hemoglobin لما دخل ال tissue ينزل حوال 12%
+
+285
+00:24:52,260 --> 00:24:58,120
+من اللي هو ال oxygen
+
+286
+00:25:04,190 --> 00:25:06,810
+ما هي العوامل اللي بتعمل اللي بتغير على شكل اللي
+
+287
+00:25:06,810 --> 00:25:09,730
+هو موقع ال Hemoglobin Oxygen Dissociation Curve
+
+288
+00:25:09,730 --> 00:25:13,790
+اللي عامل Hemoglobin Variant نوعه أنا هسوي مثال
+
+289
+00:25:13,790 --> 00:25:20,500
+Hemoglobin S هنمشي و ال decrease of oxygen
+
+290
+00:25:20,500 --> 00:25:27,340
+affinity و ال pH لما بتقل ال acidity ويوم يكون ال
+
+291
+00:25:27,340 --> 00:25:30,200
+2,3 DPG بيجي عالي بيكون ال CO2 عالي ال antimicrobial
+
+292
+00:25:30,200 --> 00:25:38,480
+عالية بيصير في shift ال curve to the right ماشي وده
+
+293
+00:25:38,480 --> 00:25:41,500
+وده فبيعني إن هذه الظروف اللي جعلنا نحكي عنها هي
+
+294
+00:25:41,500 --> 00:25:44,840
+عبارة عن ظروف بتصير فيهاش في ال tissue ففي ال
+
+295
+00:25:44,840 --> 00:25:48,980
+tissue بتصير في unloading يعني بتقل ال affinity of
+
+296
+00:25:48,980 --> 00:25:52,320
+Hemoglobin to bind with Oxygen فبتصير في releasing
+
+297
+00:25:52,320 --> 00:25:58,620
+unloading يعني ماشي وعلى العكس من ذلك يوم يكون في
+
+298
+00:25:58,620 --> 00:26:03,560
+Hemoglobin variant تاني زي Hemoglobin F إنه له
+
+299
+00:26:03,560 --> 00:26:07,590
+high affinity to Oxygen بتزيد ال affinity يوم يكون
+
+300
+00:26:07,590 --> 00:26:15,650
+زيادة في ال pH ماشي DPG قليل PCO2 قليل or
+
+301
+00:26:15,650 --> 00:26:20,270
+temperature is low بيصير في high affinity of 
+
+302
+00:26:20,270 --> 00:26:26,430
+oxygen وبالتالي بيصير shifting to the left وهي ال
+
+303
+00:26:26,430 --> 00:26:30,710
+Hemoglobin Oxygen Dissociation Curve وهي العوامل
+
+304
+00:26:30,710 --> 00:26:32,530
+اللي بتودي هيك و بتودي هيك
+
+305
+00:26:37,200 --> 00:26:44,040
+الهيموجلوبين عادي إن يتعامل
+
+306
+00:26:44,040 --> 00:26:45,240
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي بشكل عادي
+
+307
+00:26:45,240 --> 00:26:46,820
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي بشكل عادي
+
+308
+00:26:46,820 --> 00:26:47,040
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي بشكل عادي
+
+309
+00:26:47,040 --> 00:26:47,240
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي بشكل عادي
+
+310
+00:26:47,240 --> 00:26:48,340
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي بشكل عادي
+
+311
+00:26:48,340 --> 00:26:51,780
+بشكل عادي بشكل عادي بشكل عادي بشكل عادي ب
+
+312
+00:26:55,870 --> 00:27:02,330
+طبعا هذا الكلام بيحصل يوم يكون الضغط الأكسجين هو
+
+313
+00:27:02,330 --> 00:27:08,910
+27.1% و 27.5% في الفتاة وبالتالي
+
+314
+00:27:08,910 --> 00:27:11,990
+وإذا ازداد مرتبط الأكسجين الـ Dissociation Curve
+
+315
+00:27:11,990 --> 00:27:16,750
+is shifted leftward and value is reduced وإذا
+
+316
+00:27:16,750 --> 00:27:17,730
+ازداد مرتبط الأكسجين الـ Conversely decreased
+
+317
+00:27:17,730 --> 00:27:21,290
+oxygen affinity ال curve بيصير على ال right الكلام
+
+318
+00:27:21,290 --> 00:27:22,090
+هذا حاجة نحتوي
+
+319
+00:27:25,060 --> 00:27:27,960
+هذه العوامل اللي بتؤثر على ال oxygen dissociation
+
+320
+00:27:27,960 --> 00:27:35,380
+curve وهذه اللي بتعمله left shifting وهذه بتعمل
+
+321
+00:27:35,380 --> 00:27:41,120
+right shifting وهذه التانتين ونبدأ بأول هذه
+
+322
+00:27:41,120 --> 00:27:44,780
+العوامل وهي ال Bohr effect يا بنات يا شباب
+
+323
+00:27:44,780 --> 00:27:50,660
+افهموني ال Bohr effect يعني دور ال pH في علاقته
+
+324
+00:27:50,660 --> 00:27:55,720
+بال oxygen affinity ببساطة الهيموجلوبين ال oxygen
+
+325
+00:27:55,720 --> 00:28:01,920
+affinity is reduced كل مكان ال acidity أكثر طب
+
+326
+00:28:01,920 --> 00:28:06,720
+وكثيرش بيكون في acidity لما يكون الهيموجلوبين يفتشه
+
+327
+00:28:06,720 --> 00:28:10,500
+يعني فتشه بيزيد ال acidity طبعا مش بيصير في
+
+328
+00:28:10,500 --> 00:28:19,160
+metabolism ومحصلة ال metabolic pathway هي تكون ال
+
+329
+00:28:19,160 --> 00:28:23,460
+Lactate أو ال Lactic Acid ال Formation وCO2
+
+330
+00:28:23,460 --> 00:28:26,300
+والثاني يكونوا Hydrochloric Acid هو Carbonic Acid
+
+331
+00:28:26,300 --> 00:28:30,320
+والثاني عبارة عن Acid Medium فبالتالي في ال tissue
+
+332
+00:28:30,320 --> 00:28:36,920
+ال oxygen affinity is decreased مين أثرت عليه؟ ال
+
+333
+00:28:36,920 --> 00:28:44,070
+pH شو كان في دور ال pH؟ Acid طبعا هذا الكلام بيكون
+
+334
+00:28:44,070 --> 00:28:52,410
+عكسه موجود في ال Lung بيكون
+
+335
+00:28:52,410 --> 00:28:55,710
+عكسه موجود في ال Lung بيكون عكسه موجود في ال
+
+336
+00:28:55,710 --> 00:28:57,750
+Lung بيكون عكسه موجود في ال Lung بيكون عكسه موجود
+
+337
+00:28:57,750 --> 00:28:59,350
+في ال Lung بيكون عكسه موجود في ال Lung بيكون
+
+338
+00:28:59,350 --> 00:29:00,270
+عكسه موجود في ال Lung بيكون عكسه موجود في ال
+
+339
+00:29:00,270 --> 00:29:00,370
+Lung بيكون عكسه موجود في ال Lung بيكون عكسه موجود
+
+340
+00:29:00,370 --> 00:29:06,940
+في ال Lung دور الـ 2,3-DPG، وما هو الـ 2,3-DPG؟ قالوا
+
+341
+00:29:06,940 --> 00:29:09,880
+إن هذا عبارة عن مركب أحد نواتج ال glycolytic
+
+342
+00:29:09,880 --> 00:29:16,040
+pathway اللي موجودة في ال RBCs وين بتصنع في أي
+
+343
+00:29:16,040 --> 00:29:20,540
+جزء غيره، بتصنع في جزء الرابع بوصوله برينشان، وش
+
+344
+00:29:20,540 --> 00:29:26,520
+بيصير؟ بتصنع الـ 2,3-DPG في الـ glycolytic pathway،
+
+345
+00:29:26,520 --> 00:29:30,180
+طيب، إيش اللي بيصير؟ احنا بنحكي glycolytic pathway
+
+346
+00:29:30,690 --> 00:29:35,110
+يعني عمال ما بيحكي على طاقة، إنتاج طاقة وكأحد
+
+347
+00:29:35,110 --> 00:29:38,790
+المخلفات اللي بتنتج الـ 2,3-DPG اللي يوم ما ..
+
+348
+00:29:38,790 --> 00:29:44,090
+وكدهش محتاج الطاقة، فتشهر فتشهر وتزيد اللي هو ال
+
+349
+00:29:44,090 --> 00:29:48,250
+glycolytic activity فمزيد الـ 2,3-DPG ويوم ما يزيد
+
+350
+00:29:48,250 --> 00:29:52,830
+الـ 2,3-DPG قلنا هو عبارة عن منافس قوي لمين للـ
+
+351
+00:29:52,830 --> 00:29:56,850
+Hemoglobin في ارتباطه بالأكسجين فبيطلع الأكسجين،
+
+352
+00:29:56,850 --> 00:30:01,090
+بيعمل unloading للأكسجين وبيخش محل إلهاجفي نص الـ
+
+353
+00:30:01,090 --> 00:30:07,170
+Hemoglobin وبالتالي يوم يزيد الـ 2,3-DPG بيقل الـ
+
+354
+00:30:07,170 --> 00:30:12,910
+Oxygen loading بيصير Unloading بينجوسين بتقل ال
+
+355
+00:30:12,910 --> 00:30:19,270
+Affinity to Oxygen وبزيد ال Release وهي الـ 2,3
+
+356
+00:30:19,270 --> 00:30:25,350
+-DPG هي هذا اللي في النص Normal يوم زاد صار يوم قل
+
+357
+00:30:25,350 --> 00:30:27,030
+صار
+
+358
+00:30:29,700 --> 00:30:40,520
+صار سفر فوق في ال tissue اللي هو ال oxygen بي
+
+359
+00:30:40,520 --> 00:30:44,880
+بي جي بي بي جي بي بي بي بي بي بي بي بي بي بي بي بي
+
+360
+00:30:44,880 --> 00:30:46,460
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+361
+00:30:46,460 --> 00:30:47,300
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+362
+00:30:47,300 --> 00:30:47,420
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+363
+00:30:47,420 --> 00:30:53,520
+بي
+
+364
+00:30:53,520 --> 00:30:55,840
+ب
+
+365
+00:30:57,630 --> 00:31:01,510
+لما صار تمانية يعني زاد صار فيه قلة في ال oxygen
+
+366
+00:31:01,510 --> 00:31:08,170
+affinity وبالتالي shift to the right لما ال ox
+
+367
+00:31:08,170 --> 00:31:15,910
+hemoglobin stride of 2,3 DPG قل
+
+368
+00:31:15,910 --> 00:31:20,590
+فصار زيادة في ال oxygen affinity وبالتالي اتحمل ده
+
+369
+00:31:20,590 --> 00:31:24,110
+و shift to the left ماشي مرة ثانية اللي في النص
+
+370
+00:31:24,110 --> 00:31:29,300
+normal Hemoglobin L 2,3 DPG هو خمسة ملي مول per liter
+
+371
+00:31:29,300 --> 00:31:35,460
+لما زاد وصل لثمانية إيه الكيرف إيه الكيرف صار
+
+372
+00:31:35,460 --> 00:31:39,800
+على اليمين لما قلت 2,3 DPG صار الكيرف على الشمال
+
+373
+00:31:39,800 --> 00:31:44,040
+لأننا نعرف إن الكيرف لما يسير على اليمين يعني ال
+
+374
+00:31:44,040 --> 00:31:49,720
+affinity بتقل و ال release بيزيد ولما بسير نروح
+
+375
+00:31:49,720 --> 00:31:56,730
+على الشمال ال Affinity بتزيد وال Release بيقل وهي
+
+376
+00:31:56,730 --> 00:31:59,870
+زي ما قلت لكم وين بتصنع هذه ال glycolytic pathway
+
+377
+00:31:59,870 --> 00:32:03,010
+كله ال glycolytic pathway طبعا ليش؟ طبعا ال RBCs
+
+378
+00:32:03,010 --> 00:32:06,930
+وإن شاء الله هنتطرق إليه بـ .. اللي هي Glycolysis
+
+379
+00:32:06,930 --> 00:32:10,510
+قدام زي ما أنتم شايفين بيتكون من تلات أجزاء أساسية
+
+380
+00:32:10,510 --> 00:32:15,590
+الأولاني هذا هو الرئيسي ال glucose بتحول لمين؟ لـ
+
+381
+00:32:15,590 --> 00:32:20,840
+Lactate أو Lactic Acid وبتصنع في هذه العملية بيتكون
+
+382
+00:32:20,840 --> 00:32:26,760
+تلاتة ATP ثم في two pathways واحدة وهي واحدة ال pathways
+
+383
+00:32:26,760 --> 00:32:30,040
+الألمانية بيسموها Pentose Phosphate Pathway وكل اللي
+
+384
+00:32:30,040 --> 00:32:34,900
+بتصنع فيها ال NADPH اللي مطلوب for reduction of
+
+385
+00:32:34,900 --> 00:32:43,320
+oxygen و Pathway التانية زي Rapaport-Luebering Pathway  بتكون فيها
+
+386
+00:32:43,320 --> 00:32:47,860
+2,3 DPG ماشي واحدة قولنا منافس قوي
+
+387
+00:32:47,860 --> 00:32:51,320
+لمين؟ للهيموجلوبين للأكسجين في ارتباطه
+
+388
+00:32:51,320 --> 00:32:55,720
+بالهيموجلوبين دي
+
+389
+00:32:55,720 --> 00:33:00,520
+اللي هو كيف يتكون الأيام
+
+390
+00:33:00,520 --> 00:33:04,400
+يكون ال oxygen is unloaded with Hemoglobin by
+
+391
+00:33:04,400 --> 00:33:09,440
+Hemoglobin 2,3 DPG بيكون داخل ال Hemoglobin وبيسمو
+
+392
+00:33:09,440 --> 00:33:12,520
+ال Hemoglobin molecule في هذه الحالة Tense Form
+
+393
+00:33:12,520 --> 00:33:18,140
+Tense Form ليش؟ لإن هو فاضي أو فضة اللي مجلد محمل
+
+394
+00:33:18,140 --> 00:33:24,440
+الـ 2,3-DPG المحصلة ال Affinity to Oxygen is
+
+395
+00:33:24,440 --> 00:33:29,580
+lowered ولمّا يكون العكس الـ 2,3-DPG is expelled
+
+396
+00:33:29,580 --> 00:33:36,840
+out زاد ال Oxygen Affinity الـ PO2 Pressure of
+
+397
+00:33:36,840 --> 00:33:40,900
+Oxygen وهذا بيزيد في ال Lung الـ 2,3-DPG بيصل ال
+
+398
+00:33:40,900 --> 00:33:45,880
+Expelling out والهيموجلوبين بتحمل بالأكسجين وبيسموه
+
+399
+00:33:45,880 --> 00:33:49,640
+ال Relaxed Form وفي هذا الحال ال affinity to
+
+400
+00:33:49,640 --> 00:33:54,440
+oxygen is high وهذه العملية ما بتحول الهيموجلوبين من
+
+401
+00:33:54,440 --> 00:33:58,080
+Tense to Relax تينس توريلاكس تينس توريلاكس تينس
+
+402
+00:33:58,080 --> 00:33:59,700
+توريلاكس تينس توريلاكس تينس توريلاكس تينس توريلاكس
+
+403
+00:33:59,700 --> 00:34:02,220
+تينس توريلاكس تينس توريلاكس تينس توريلاكس تينس
+
+404
+00:34:02,220 --> 00:34:05,360
+توريلاكس تينس
+
+405
+00:34:05,360 --> 00:34:09,120
+توريلاكس
+
+406
+00:34:09,120 --> 00:34:14,060
+Tense to Relax Ability of Hemoglobin to bind to 2,3
+
+407
+00:34:14,060 --> 00:34:17,940
+-DPG وهذا الكلام بيحصل في ال Fetal Hemoglobin الـ
+
+408
+00:34:17,940 --> 00:34:22,520
+Fetal Hemoglobin ما عنده القدرة على الارتباط بالـ
+
+409
+00:34:22,520 --> 00:34:26,900
+2,3-DPG فبيضل محمل قصاد بالأكسجين وبالتالي ال
+
+410
+00:34:26,900 --> 00:34:33,620
+affinity to oxygen is high 
+
+411
+00:34:33,620 --> 00:34:36,640
+2,3-DPG concentration بتتأثر بعدة عوامل منها على
+
+412
+00:34:36,640 --> 00:34:41,670
+سبيل المثال ال Hypoxia فجالة في حالات ال Hypoxia بيصير
+
+413
+00:34:41,670 --> 00:34:50,810
+فيه زيادة في تركيز الـ 2,3 DPG وال Oxygen
+
+414
+00:34:50,810 --> 00:34:59,130
+Affinity بتقل كمان ال Delivery of Oxygen
+
+415
+00:34:59,130 --> 00:35:01,410
+to tissue is facilitating
+
+416
+00:35:04,240 --> 00:35:07,880
+على سبيل المثال في بعض حالات الـ Hypoxia زي الـ
+
+417
+00:35:07,880 --> 00:35:10,600
+High Altitude والـ Anoxia والـ Pulmonary or
+
+418
+00:35:10,600 --> 00:35:14,500
+Cardiac Disease or Blood Loss or Anemia ماشي هذا
+
+419
+00:35:14,500 --> 00:35:22,860
+الكلام بيصير لـ 2,3 DPG بيجي بيصير له زيادة
+
+420
+00:35:22,860 --> 00:35:26,640
+ويوم ما يزيد بقعد في ال Oxygen فبالتالي ال 
+
+421
+00:35:26,640 --> 00:35:29,440
+Affinity to Oxygen بيقعد في الـ Hemoglobin فبالتالي
+
+422
+00:35:29,440 --> 00:35:32,840
+الـ Affinity to Oxygen بتقل و Release of Oxygen 
+
+423
+00:35:32,840 --> 00:35:37,330
+كمان بتقل، هذا نوع من الـ adaptation نوع من الـ
+
+424
+00:35:37,330 --> 00:35:42,090
+adaptation، الزيادة في الـ 2,3-DPG بتلعب 
+
+425
+00:35:42,090 --> 00:35:45,230
+دور كبير في الـ adaptation to exercise also يوم
+
+426
+00:35:45,230 --> 00:35:50,010
+الواحد يجري ويفقد كميات كبيرة من أيش من اللي هو 
+
+427
+00:35:50,010 --> 00:35:56,330
+الطاقة، الحالة المطلوبة أن نعمل adaptation، كيف يحدث 
+
+428
+00:35:56,330 --> 00:35:59,050
+الـ adaptation؟ نريد أن نقلل كمية الـ oxygen اللي
+
+429
+00:35:59,050 --> 00:36:04,330
+نفقدها، فبتدخل تركيز الـ 2,3-DPG بيتحمل في 
+
+430
+00:36:04,330 --> 00:36:07,730
+الهيموجلوبين، بيقل الـ Hemoglobin affinity بيتقل 
+
+431
+00:36:07,730 --> 00:36:13,730
+الـ Hemoglobin release عامة
+
+432
+00:36:13,730 --> 00:36:16,330
+الآخر بيؤثر على الـ Hemoglobin، كاربون دايوكسايد، كاربون
+
+433
+00:36:16,330 --> 00:36:23,390
+دايوكسايد، طبعا ما بترتبط الشرطبات مباشر بالـ Hemoglobin 
+
+434
+00:36:23,390 --> 00:36:26,630
+وإنما بيصير الـ diffusion في داخل الـ RBCs و
+
+435
+00:36:26,630 --> 00:36:29,990
+diffusion في داخل الـ Hemoglobin، لكنه بيصير الـ
+
+436
+00:36:29,990 --> 00:36:34,610
+diffusion بالقاتل قبل ما يصير الـ Hemoglobin لو CO2
+
+437
+00:36:34,610 --> 00:36:39,510
+بيتعرض ده إيش لـ two reaction، أول reaction CO2 مع
+
+438
+00:36:39,510 --> 00:36:44,910
+ماء بيكون carbonic acid والـ carbonic acid يتحول
+
+439
+00:36:44,910 --> 00:36:47,250
+إلى بيكربونيت وهيدروجين
+
+440
+00:36:51,020 --> 00:36:55,320
+ماشي، أي الـ carbon dioxide diffuse freely into the
+
+441
+00:36:55,320 --> 00:37:02,100
+RBCs، و هذا بيشكل اللي هو أيش أنه الـ reaction
+
+442
+00:37:02,100 --> 00:37:07,660
+الأولاني أن الـ H+ liberated in reaction
+
+443
+00:37:07,660 --> 00:37:12,650
+two is accepted by deoxygenated hemoglobin، وهذه
+
+444
+00:37:12,650 --> 00:37:16,790
+طبعا اللي بيأثر فيها هو عبارة عن Bohr Effect الـ
+
+445
+00:37:16,790 --> 00:37:23,090
+Bicarbonate جثتها جثة، بس كل ما هناك أنه هي diffuse
+
+446
+00:37:23,090 --> 00:37:29,130
+freely across the red cell membrane، وجزء منها
+
+447
+00:37:29,130 --> 00:37:33,890
+بيصير exchange هو الـ chloride اللي موجود في
+
+448
+00:37:33,890 --> 00:37:39,870
+البلازما، بيسموها chloride shift، الـ bicarbonate بعد
+
+449
+00:37:39,870 --> 00:37:43,640
+ذلك بتنعمل in plasma to the lung، وهناك بيصلها
+
+450
+00:37:43,640 --> 00:37:49,480
+ventilation as PCO2 is low، وبيؤدي إلى الـ
+
+451
+00:37:49,480 --> 00:37:56,020
+excretion أو excretion of CO2، لأن 70% من الـ carbon
+
+452
+00:37:56,020 --> 00:38:02,240
+dioxide بيتم التخلص منه بهذه الطريقة، و 30% اللي 
+
+453
+00:38:02,240 --> 00:38:06,760
+دايرين 5% موجودين هنا simple solution، و 25%
+
+454
+00:38:06,760 --> 00:38:09,900
+برتبطوا بالـ Hemoglobin وبيكونوا Carb amino
+
+455
+00:38:09,900 --> 00:38:15,790
+Hemoglobin، مت-هيموجلوبين، احنا مطلوب منها أن 
+
+456
+00:38:15,790 --> 00:38:21,670
+الـ هيموجلوبين يظل دائما بحالة in reduced form و
+
+457
+00:38:21,670 --> 00:38:25,650
+reduced form اللي احنا نبسط فيه إن الفرس إن الـ
+
+458
+00:38:25,650 --> 00:38:30,830
+iron atom يظل in its ferrous form يعني reduced form
+
+459
+00:38:30,830 --> 00:38:36,430
+لما يتأكسد الحديد يبطل عنده القدرة على إيش على 
+
+460
+00:38:36,430 --> 00:38:42,810
+الارتباط بالـ هيموجلوبين أو حمل الـ هيموجلوبين، ليه؟ عشان يكلا
+
+461
+00:38:42,810 --> 00:38:45,450
+في داخل الكريات الدم الحمراء في عدة ميكانيزم
+
+462
+00:38:45,450 --> 00:38:50,850
+مسئولة عن إيش؟ عن الحفاظ بشكل دائم على الـ reduced
+
+463
+00:38:50,850 --> 00:38:55,790
+form of hemoglobin، وقت إيش بيحصل في مت-هيموجلوبين؟
+
+464
+00:38:55,790 --> 00:38:58,930
+قالوا فيه تلات حالات، الحالة الأولانية إذا كان الـ
+
+465
+00:38:58,930 --> 00:39:02,330
+RBCs is exposed to certain oxidant و لا كله مابخش
+
+466
+00:39:02,330 --> 00:39:05,910
+أكسيدانت، المطلوب من الـ RBCs أنه يخلصنا من الـ
+
+467
+00:39:05,910 --> 00:39:10,870
+oxidant، أول بول نمرة اتنين إذا كان الـ intrinsic
+
+468
+00:39:10,870 --> 00:39:13,450
+protective mechanism اللي هو الـ ميكانيزم الداخلي
+
+469
+00:39:13,450 --> 00:39:18,190
+هذا خرب اللي بيحافظ على الـ reduced form، نمرة تلاتة 
+
+470
+00:39:18,190 --> 00:39:21,370
+إذا كان فيه genetic abnormality؟ قالوا في بعض
+
+471
+00:39:21,370 --> 00:39:22,570
+النوع من الـ Hemoglobin
+
+472
+00:39:25,190 --> 00:39:31,370
+بـ affected اللي هو global stability أو اللي هو الـ 
+
+473
+00:39:31,370 --> 00:39:34,690
+Hemoglobin، طبعا هذه أدولة صورتين، الصورة هذه عبارة
+
+474
+00:39:34,690 --> 00:39:38,310
+عن ميكانيزم تبع الـ Intrapascular Hemolysis، وزي ما
+
+475
+00:39:38,310 --> 00:39:40,990
+أنتوا شايفين أنا مش راح آخد فيها، هتاخدها في الـ
+
+476
+00:39:40,990 --> 00:39:45,770
+clinical chemistry بالتفصيل في الـ Intrapascular
+
+477
+00:39:45,770 --> 00:39:49,090
+Hemolysis، بتسرع قوة الدم الحمرة، وبيزيد الـ Bilirubin
+
+478
+00:39:49,450 --> 00:39:52,190
+بيقل الـ Haptoglobin، الـ Haptoglobin هو عبارة عن
+
+479
+00:39:52,190 --> 00:39:58,390
+Hemoglobin Carrier Compound، فلما بيزيد الـ
+
+480
+00:39:58,390 --> 00:40:00,950
+Hemoglobin اللي طالع من داخل الخلايا مرتبط بالـ 
+
+481
+00:40:00,950 --> 00:40:03,510
+Haptoglobin، فبيقل الـ Hemoglobin الـ Haptoglobin
+
+482
+00:40:03,510 --> 00:40:09,290
+تركيزا، ماشي، و بضل فدي عندنا Free Hemoglobin موجود 
+
+483
+00:40:09,290 --> 00:40:12,790
+برضه، و أيضا الـ Extravascular زي ما أنتوا شايفين 
+
+484
+00:40:12,790 --> 00:40:16,370
+هاي الـ Hemoglobin بتتكسر، شره Hemoglobin اللي بناخد
+
+485
+00:40:16,370 --> 00:40:22,110
+من الـ Iron، بضل Globin، هو بيظل اللي هو الـ .. الـ ..
+
+486
+00:40:22,110 --> 00:40:22,950
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+487
+00:40:22,950 --> 00:40:23,310
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+488
+00:40:23,310 --> 00:40:23,370
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+489
+00:40:23,370 --> 00:40:24,130
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+490
+00:40:24,130 --> 00:40:25,910
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+491
+00:40:25,910 --> 00:40:26,230
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+492
+00:40:26,230 --> 00:40:31,410
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+493
+00:40:31,410 --> 00:40:32,270
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+494
+00:40:32,270 --> 00:40:32,350
+الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+495
+00:40:32,350 --> 00:40:36,330
+.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ ..
+
+496
+00:40:36,330 --> 00:40:43,350
+الـ .. الـ .. الـ .. الـ .. الـ 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8b722f59cb19520a9800b5840e1ac28188324e3e
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_postprocess.srt
@@ -0,0 +1,1984 @@
+1
+00:00:01,820 --> 00:00:06,220
+بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوقع و
+
+2
+00:00:06,220 --> 00:00:10,100
+نجمعين اليوم ان شاء الله هنشتغل او هنتكلم في
+
+3
+00:00:10,100 --> 00:00:17,980
+المحاضرة رقم 4 اللي بتحكي عن ال hemoglobin
+
+4
+00:00:17,980 --> 00:00:21,120
+synthesis structure and function
+
+5
+00:00:28,590 --> 00:00:32,650
+طيب هذه الصورة بتبين اللي هو ال structure of
+
+6
+00:00:32,650 --> 00:00:37,150
+Hemoglobin وزي ما انتوا شايفين ال Hemoglobin
+
+7
+00:00:37,150 --> 00:00:42,230
+بيتكوّن من two .. four polypeptide chain تنتين
+
+8
+00:00:42,230 --> 00:00:45,570
+Alpha وتنتين Beta وكل واحدة من ال polypeptide
+
+9
+00:00:45,570 --> 00:00:52,370
+chain مرتبطة بهم موليكيول مرتبطة بهم موليكيول
+
+10
+00:00:52,370 --> 00:00:55,450
+وبالتالي فينا four globin
+
+11
+00:00:57,020 --> 00:01:04,720
+مع فور هيم و ال normal hemoglobin بيعتبر هو عبارة
+
+12
+00:01:04,720 --> 00:01:08,180
+عن ال hemoglobin اللي له two dissimilar globin
+
+13
+00:01:08,180 --> 00:01:14,040
+chainintroduction طبعا الهيموجلوبين هو برعنة أه
+
+14
+00:01:14,040 --> 00:01:16,680
+red globular protein which have molecular weight
+
+15
+00:01:16,680 --> 00:01:23,220
+64500 الهيموجلوبين بيشكلوا تلت وزن الخلية ووظيفته
+
+16
+00:01:23,220 --> 00:01:26,640
+الأساسية هي نقل ال oxygen من ال lung لل tissue
+
+17
+00:01:26,640 --> 00:01:31,000
+واللي اليوم نعرف حوالي أكتر من 500 different
+
+18
+00:01:31,000 --> 00:01:35,600
+hemoglobin variant كلهم يلهم نفس ال structure لكن
+
+19
+00:01:35,600 --> 00:01:38,960
+اللي بدنا ناخده في عين الاعتبار أنه ال normal
+
+20
+00:01:38,960 --> 00:01:43,530
+hemoglobinnormal functioning hemoglobin هو عبارة
+
+21
+00:01:43,530 --> 00:01:47,010
+عن الـ hemoglobin اللي بيحتوي أو بيتكوّن من two
+
+22
+00:01:47,010 --> 00:01:52,210
+pairs of dissimilar globin chain نبدأ بال
+
+23
+00:01:52,210 --> 00:01:57,810
+hemoglobin synthesis أول جزء من المحاضرة و طبعا
+
+24
+00:01:57,810 --> 00:02:00,830
+كلكم بتعرف ان ال hemoglobin بيتكوّن من hemoglobin
+
+25
+00:02:00,830 --> 00:02:06,790
+و كل واحد بيتصنع في منطقة أو في لألة واحدة في
+
+26
+00:02:06,790 --> 00:02:15,360
+developing RBCsdeveloping red cell precursor وعشان
+
+27
+00:02:15,360 --> 00:02:21,580
+يطلع الـ hemoglobin بكمياته الطبيعية لابد من أن
+
+28
+00:02:21,580 --> 00:02:28,440
+يكون في coordination يعني توازي في ال hemoglobin
+
+29
+00:02:28,440 --> 00:02:33,720
+assembly hemoglobin assembly
+
+30
+00:02:38,880 --> 00:02:44,920
+تبدأ بالـ Heme Synthesis وهو كما تشاهدون الفيجر
+
+31
+00:02:44,920 --> 00:02:52,320
+يمثل خطوات الـ Heme Synthesis ويبدأ أول خطواته رقم
+
+32
+00:02:52,320 --> 00:02:57,440
+1,2,3,4 بالأحمر لغاية سبعة خطوات يبدأ في الميتر
+
+33
+00:02:57,440 --> 00:03:02,590
+كندرية هذه عبارة عن الخليةالدائرة اللي في النص هي
+
+34
+00:03:02,590 --> 00:03:05,510
+عبارة عن ميتوكندرية وبره هي عبارة عن الـ cytoplasm
+
+35
+00:03:05,510 --> 00:03:10,310
+فالخطوات اللي هي متبدأ في الميتوكندرية لإنها أول
+
+36
+00:03:10,310 --> 00:03:13,990
+خطوة هي عبارة عن energy dependent process أو step
+
+37
+00:03:13,990 --> 00:03:18,370
+وبالتالي بدها ياش بدها تكون في الميتوكندرية فهي
+
+38
+00:03:18,370 --> 00:03:22,250
+عبارة عن Saxon Neon-GME مع Glycine بدينا Delta
+
+39
+00:03:22,250 --> 00:03:27,070
+-Amino-Lavoranic Acid خطوة بتعتبر rate limiting
+
+40
+00:03:27,070 --> 00:03:33,070
+steps ومن خلالها نقدر نعملControl كل العملية بتزيد
+
+41
+00:03:33,070 --> 00:03:45,250
+إذا كان فيه Iron كتير و بتقل
+
+42
+00:03:45,250 --> 00:03:53,110
+يوم ما يكون فيه Hem كتير إذا زاد ال Hem بتقل هذه
+
+43
+00:03:53,110 --> 00:03:57,690
+العمليةوهكذا بتعتبر rate limiting steps خلّينا
+
+44
+00:03:57,690 --> 00:04:03,750
+نشوفها ده هي عبارة عن ساكسيني الكونزين Aعلى دلتا
+
+45
+00:04:03,750 --> 00:04:06,830
+امينورفلانكاسيتس خطوة تانية تنين منه بيطلع على ال
+
+46
+00:04:06,830 --> 00:04:10,290
+سايتو بلازم و اتنين منه بيكونوا ال power of a
+
+47
+00:04:10,290 --> 00:04:13,690
+pilonogen اللي بتحول اليارو power of a pilonogen
+
+48
+00:04:13,690 --> 00:04:17,630
+تلاتة ثم كوبرا power of a pilonogen تلاتة اللي
+
+49
+00:04:17,630 --> 00:04:20,410
+برجع مرة تانية by unknown ميكانيزم على ال
+
+50
+00:04:20,410 --> 00:04:25,610
+mitochondria وهناك بتحول ل protoporphrin تسعة اللي
+
+51
+00:04:25,610 --> 00:04:29,050
+بتحول لprotoporphrin تسعة اللي في النهاية بخش ال
+
+52
+00:04:29,050 --> 00:04:34,200
+iron علىفي نص المليكيورو بيكون الهيمين ونبدأ نشوف
+
+53
+00:04:34,200 --> 00:04:42,340
+واحدة واحدة هذه الخطوات هذه
+
+54
+00:04:42,340 --> 00:04:46,780
+أول خطوة سكسينيدكو انزيم A مع Glycine Delta Amino
+
+55
+00:04:46,780 --> 00:04:50,920
+Avorinic Acid Synthetase Enzyme بيدينا Delta Amino
+
+56
+00:04:50,920 --> 00:04:57,220
+Avorinic Acid أو الوفيرانيد في النهاية هذه ايه؟ زي
+
+57
+00:04:57,220 --> 00:05:03,180
+ما قلتلكم EnergyDependent و الانزيم
+
+58
+00:05:03,180 --> 00:05:07,160
+دلتامينورليكاسيدسينتريتس هو المسئول عنها تعتبر
+
+59
+00:05:07,160 --> 00:05:12,360
+فيها limiting steps في تصنيع الهيم و غالبا
+
+60
+00:05:12,360 --> 00:05:15,600
+stimulated in the presence of globin sorry و
+
+61
+00:05:15,600 --> 00:05:20,580
+inhibited in the presence of free heme تعتبر
+
+62
+00:05:20,580 --> 00:05:24,500
+control هذه الخطوة control mechanism و بتحتاج إلى
+
+63
+00:05:24,500 --> 00:05:28,720
+عدة عوامل منها vitamin b6 في الرأس و copper ion
+
+64
+00:05:30,020 --> 00:05:34,760
+والـ Synthesis of Delta Amino Uric Acid Synthetase
+
+65
+00:05:34,760 --> 00:05:38,520
+is also inhibited in the presence of free heme
+
+66
+00:05:38,520 --> 00:05:44,700
+يعني كمان الإنزيم بيهيجف ودي بتعتبر فيرثال اللي هو
+
+67
+00:05:44,700 --> 00:05:48,560
+Feedback Inhibition Mechanism بقى الهيجزة نادر
+
+68
+00:05:48,560 --> 00:05:52,980
+ماركوتو مليكيول of Delta Amino Uric Acid are
+
+69
+00:05:52,980 --> 00:05:54,320
+Diamerized
+
+70
+00:05:57,010 --> 00:06:08,250
+في وجود دلتا امينو أو دلتا امينو ديهيدرتيز او
+
+71
+00:06:08,250 --> 00:06:14,510
+بيسموه ال Porphopilenogen سينتيز تمام انه
+
+72
+00:06:14,510 --> 00:06:20,430
+ديامارايز و بيكونوا ال Porphopilenogen و ال next
+
+73
+00:06:20,430 --> 00:06:24,250
+step هي تكوين ال Porphyrin ring و ال Porphyrin
+
+74
+00:06:24,250 --> 00:06:30,970
+ring هي one ringone unit of pyroring وزي ما انتوا
+
+75
+00:06:30,970 --> 00:06:36,070
+شايفين بيتكون ال euro porphyrinogen تلاتة معايا
+
+76
+00:06:36,070 --> 00:06:42,670
+اللي بيصله decarboxylase decarboxylation by
+
+77
+00:06:42,670 --> 00:06:47,610
+decarboxylase enzyme إلى cobra porphyrinogen تلاتة
+
+78
+00:06:47,610 --> 00:06:51,530
+وبعد
+
+79
+00:06:51,530 --> 00:06:57,620
+هيك ال cobra porphyrinogen تلاتةبيصير بيوكسديز
+
+80
+00:06:57,620 --> 00:07:03,720
+انزايم بيتحول ل Protoporphin 9 في الميتوكندرية
+
+81
+00:07:03,720 --> 00:07:07,660
+يعني بيخش مرة تانية عن الميتوكندرية و ال
+
+82
+00:07:07,660 --> 00:07:14,860
+Protoporphin 9 بيتحول بيض و ايضا بيوكسديز انزايم
+
+83
+00:07:14,860 --> 00:07:18,080
+الى Protoporphin 9 و هي يصار ال four parallel ring
+
+84
+00:07:18,080 --> 00:07:24,220
+تكونات ثم بعد ذلك لم يبقى الا الى ذرة الحديد انها
+
+85
+00:07:24,220 --> 00:07:29,630
+تخش في النصالبروتوبرفين 9 في نص الموليكيولو يكون
+
+86
+00:07:29,630 --> 00:07:35,250
+نقاش الهيم الانزيمي المسؤول عن هذه العملية هو
+
+87
+00:07:35,250 --> 00:07:39,550
+الferrochelatase انزايم التالي احنا مرّين عليه في
+
+88
+00:07:39,550 --> 00:07:45,270
+ال .. في ال Sidroplastic Anemia إذا فاكرين هو و ال
+
+89
+00:07:45,270 --> 00:07:48,770
+Delta Aminolucric Acid Synthetase two انزايم
+
+90
+00:07:48,770 --> 00:07:52,790
+مسؤولين عن اللي هو تصنيع الهيم
+
+91
+00:07:56,410 --> 00:08:00,290
+Globin Synthesis التاني اللي هو جزء التاني من الـ
+
+92
+00:08:00,290 --> 00:08:04,330
+Hemoglobin قالوا هذا Globin يعني جزء من البروتين
+
+93
+00:08:04,330 --> 00:08:08,090
+يعني اللي مسؤول عنه تصنيع عن تصنيعه جينات قالوا
+
+94
+00:08:08,090 --> 00:08:11,950
+غالبا في عندنا تمانية functional Globin gene
+
+95
+00:08:11,950 --> 00:08:19,250
+مسؤولين عن تصنيع two-duplicate Globin molecule
+
+96
+00:08:19,250 --> 00:08:26,070
+موجودين in two-duplicate جيني clusterبيتا لايك
+
+97
+00:08:26,070 --> 00:08:29,550
+والفا لايك البيتا لايك ال cluster موجودة على
+
+98
+00:08:29,550 --> 00:08:36,090
+كرومزوم 11 والالفا لايك على كرومزوم 16 التمن دينات
+
+99
+00:08:36,090 --> 00:08:40,850
+هدول مسؤولين عن تصنيع ست أنواع من الoglobin chain
+
+100
+00:08:40,850 --> 00:08:46,130
+او polypeptide اللي هم الفا وبيتا وجاما ودلتا
+
+101
+00:08:46,130 --> 00:08:52,280
+وإبسلون وزيتاكيف يتم الانتوجيني of globin tree
+
+102
+00:08:52,280 --> 00:08:57,240
+synthesis وهذه مهمة صحية طبعا بيتم تصنيع الجلوبين
+
+103
+00:08:57,240 --> 00:09:08,320
+حسب اللي هو المراحل اللي بتمر فيها الجمين
+
+104
+00:09:09,330 --> 00:09:13,690
+يعني حسب مراحل تكوين الإنسان ففي الجنين على سبيل
+
+105
+00:09:13,690 --> 00:09:19,170
+المثال أول مراحل تكوينه تبدأ في اليكساك at two to
+
+106
+00:09:19,170 --> 00:09:23,930
+three weeks of gestation أول ما يبدأ يتصنع إلى الـ
+
+107
+00:09:23,930 --> 00:09:27,790
+zeta والإبسلون بلوبين chain ويكونون التنين مع بعض
+
+108
+00:09:27,790 --> 00:09:33,230
+Hemoglobin اسمه Gawar-1 زيتا إبسلون كوربتو و by
+
+109
+00:09:33,230 --> 00:09:36,630
+five weeks of gestation أيضا في اليكساك الجامع
+
+110
+00:09:36,630 --> 00:09:41,870
+والألفة تبدأ تتصنعوبصير عندنا أربعةoglobin chain
+
+111
+00:09:41,870 --> 00:09:46,510
+بتوافق والتباديل بيعملولنا كمان اتنين hemoglobin
+
+112
+00:09:46,510 --> 00:09:50,510
+واحد اسمه Portland والتاني جوار two وبالتالي بيصير
+
+113
+00:09:50,510 --> 00:09:55,090
+عندنا تلاتة أنواع من ال hemoglobin Portland زيتا
+
+114
+00:09:55,090 --> 00:10:00,890
+جامعة الكلتو و جوار اللي هو two هو عبارة عن Alpha
+
+115
+00:10:00,890 --> 00:10:07,540
+Epsilon كلتوطبعا بيبدأ زيادة الجامعة والألف على
+
+116
+00:10:07,540 --> 00:10:12,620
+حساب زيتا وإبسلون نصل لمرحلة بيبدأ دور ال liver
+
+117
+00:10:12,620 --> 00:10:19,420
+وكل اللي بيتصنع هو Alpha Gamma و بتبدأ ال Beta ثم
+
+118
+00:10:19,420 --> 00:10:23,800
+تليها ال Delta في التصنيع ففي ال liver من ستة
+
+119
+00:10:23,800 --> 00:10:27,740
+لتلاتين weeks ال main hemoglobin اللي بيتصنع هو
+
+120
+00:10:27,740 --> 00:10:33,240
+Alpha Gamma Twoولمّا تبدأ تصنع الـ Delta جزء منها
+
+121
+00:10:33,240 --> 00:10:39,400
+بيصنع لنا Alpha Delta 2 Hemoglobin A2 وبعد ذلك
+
+122
+00:10:39,400 --> 00:10:47,700
+ببعد الولادة البومارو هو الأساس في تصنيع ال RBC's
+
+123
+00:10:47,700 --> 00:10:52,500
+أو ال Hemopoiesis ودم ال Hemoglobin الأساسي في هذا
+
+124
+00:10:52,500 --> 00:10:58,640
+الحالة بيكون Hemoglobin A وهو Alpha Beta 2 وهذا
+
+125
+00:10:58,640 --> 00:11:04,260
+عبارة عنالـ switching of hemoglobin في المراحل
+
+126
+00:11:04,260 --> 00:11:11,660
+المختلفة تبعت اللي هو ال embryonic life و بعدها في
+
+127
+00:11:11,660 --> 00:11:16,220
+ال neonatal life ففي ال embryonic ده هو جوهر واحد
+
+128
+00:11:16,220 --> 00:11:20,800
+نقول Portland جوهر two y, z, و epsilon اي شي
+
+129
+00:11:20,800 --> 00:11:27,200
+بتكونوا embryo في ال fetus بعد هيك بتبدأ الجالفة
+
+130
+00:11:27,200 --> 00:11:33,070
+والجامعةوبدو يزيدوا على حساب ياش ال zeta والإبسلون
+
+131
+00:11:33,070 --> 00:11:36,430
+وفي هذه الحالة بيكون ال liver هو الأساس و ال major
+
+132
+00:11:36,430 --> 00:11:40,470
+hemoglobin هو ال hemoglobin F وإذا دخلت تالتة أدي
+
+133
+00:11:40,470 --> 00:11:48,970
+على الخط بيصير hemoglobin E2 على اللي بتصنع بعد
+
+134
+00:11:48,970 --> 00:11:54,510
+هيك ال bomber هو الأساس في كل تصنيع ال hemoglobin
+
+135
+00:11:54,510 --> 00:11:58,380
+وزي ما انتوا شايفين ال alpha و ال beta هي الأساسو
+
+136
+00:11:58,380 --> 00:12:06,220
+هناك قليل من Gamma طبعا
+
+137
+00:12:06,220 --> 00:12:09,520
+هذه الـ switching phenomena اللي بتصير ده هي أول
+
+138
+00:12:09,520 --> 00:12:14,360
+شي بيكون في زيتا تبدأ تزيد Alpha على حساب زيتا و
+
+139
+00:12:14,360 --> 00:12:20,800
+أنا ببدأ اللي هو يزيد Gamma على حساب إبسلون فتنزل
+
+140
+00:12:20,800 --> 00:12:28,110
+الإبسلون و بتزيد Gamma بعد الحل للولادة بيصيريعني
+
+141
+00:12:28,110 --> 00:12:39,250
+after birth بيصير ال beta و ال alpha هي الأساس اه
+
+142
+00:12:39,250 --> 00:12:44,730
+sorry ال beta بتزيد على حساب gamma ده هي فكله
+
+143
+00:12:44,730 --> 00:12:49,470
+بيصير alpha و betaأدل الهيموجلوبين في النهاية
+
+144
+00:12:49,470 --> 00:12:53,490
+بيكون عبارة عن مرمى الأدل الهيموجلوبين بيكون عبارة
+
+145
+00:12:53,490 --> 00:12:59,970
+عن الهيموجلوب A Alpha 2 Beta 2 96-98% وA2 Alpha
+
+146
+00:12:59,970 --> 00:13:04,750
+Delta الكل 2 و نص واحد و نص لتلاتة و اتنين و ده
+
+147
+00:13:04,750 --> 00:13:08,010
+مهم جدا لتحديد أنواع مغينة من القديمة بالذات
+
+148
+00:13:08,010 --> 00:13:13,350
+ثلاثينية فهو الهيموجلوب F وهو Alpha 2 Gamma 2 وهو
+
+149
+00:13:13,350 --> 00:13:16,250
+أقل من واحد في المية point five to point eight
+
+150
+00:13:16,250 --> 00:13:21,340
+percentageوهذا الـ Global Synthesis قلنا على two
+
+151
+00:13:21,340 --> 00:13:25,620
+gene cluster واحد اللي هو كرمزوم رقم 11 والتاني 16
+
+152
+00:13:25,620 --> 00:13:29,620
+الكرمزوم رقم 11 موجود عليه ال beta-like gene
+
+153
+00:13:29,620 --> 00:13:33,320
+cluster وزي ما تشايفين فينا Beta gene Delta gene
+
+154
+00:13:33,320 --> 00:13:37,780
+Magama gene و Epsilon يعني أربع أنواع من إيه الشيء
+
+155
+00:13:37,780 --> 00:13:42,680
+الجيناتالجامعة هن في عندنا نوعين بيختلفوا فقط في
+
+156
+00:13:42,680 --> 00:13:47,220
+أمينو أسد واحد وهو الـG والـA الألانين والعيسين في
+
+157
+00:13:47,220 --> 00:13:50,780
+رقم
+
+158
+00:13:50,780 --> 00:13:57,660
+145 أمينو أسد بينما
+
+159
+00:13:57,660 --> 00:14:03,800
+الـAlpha Globin gene cluster موجودة على كرمزوم رقم
+
+160
+00:14:03,800 --> 00:14:08,320
+16 وزي ما تشوفون في عندنا زيتا نوعين they are
+
+161
+00:14:08,320 --> 00:14:11,530
+similarوAlpha نوعين يعني two types of globin
+
+162
+00:14:11,530 --> 00:14:17,130
+بيتصنعوا اتنين نفس الكمية ونفس النوع من Alpha
+
+163
+00:14:17,130 --> 00:14:24,510
+وبنوع ال hemoglobin المختلفة وما يدخل في تركيبها
+
+164
+00:14:24,510 --> 00:14:31,850
+Structure ال structure بيتكوّن
+
+165
+00:14:31,850 --> 00:14:34,510
+من أربع أشكال primary و secondary و tertiary و
+
+166
+00:14:34,510 --> 00:14:37,790
+quaternary ال primary بيعتمد على
+
+167
+00:14:43,950 --> 00:14:48,010
+الله أبو صلى الله عليه و سلم و محمد الـ primary
+
+168
+00:14:48,010 --> 00:14:49,650
+structure of the global reflected in the amino
+
+169
+00:14:49,650 --> 00:14:54,330
+acid sequence of the various chains امينو أسل
+
+170
+00:14:54,330 --> 00:15:00,010
+سيكوانس يعني فقط بنعد واحد ورا التاني ماشي بينما
+
+171
+00:15:00,010 --> 00:15:06,030
+ال secondary يبقى تكوّن من 9 non helical joined
+
+172
+00:15:06,030 --> 00:15:12,550
+with 8 helicalالـ Helical بيعطوهم
+
+173
+00:15:12,550 --> 00:15:19,030
+أرقام A,B,C بينما الـ Non-helical هو عبارة عن يعني
+
+174
+00:15:19,030 --> 00:15:24,770
+وصلة ما بين two helical فبتاخد الرقامين القبل
+
+175
+00:15:24,770 --> 00:15:27,990
+واللي بعد يعني ال helical اللي جابلها و ال helical
+
+176
+00:15:27,990 --> 00:15:31,630
+اللي بعدها فبتصير لنا مثلًا على سبيل المثال الـ
+
+177
+00:15:31,630 --> 00:15:37,490
+Non-helicalالأولى هي A B وهي ما بين الهليكس A و
+
+178
+00:15:37,490 --> 00:15:41,690
+الهليكس B وهذا هو مصمم الهليكس الهليكس الانهليكس
+
+179
+00:15:41,690 --> 00:15:45,170
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+180
+00:15:45,170 --> 00:15:46,970
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+181
+00:15:46,970 --> 00:15:47,350
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+182
+00:15:47,350 --> 00:15:48,570
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+183
+00:15:48,570 --> 00:15:54,850
+الانهليكس
+
+184
+00:15:54,850 --> 00:16:00,130
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+185
+00:16:00,130 --> 00:16:04,500
+الانهليكس الانهليكس الانهليكس الانههي مجلبة تأخذ
+
+186
+00:16:04,500 --> 00:16:14,160
+شكل الـ Sphere وبيتكلم عن Intramolecular Bonds هي
+
+187
+00:16:14,160 --> 00:16:18,780
+المسؤولة عن الـ helical partوهي مسؤولة عن ال
+
+188
+00:16:18,780 --> 00:16:25,500
+agility of the molecule و بتؤدي إلى تصميم انها
+
+189
+00:16:25,500 --> 00:16:29,520
+نهرك و جالوا في ال tertiary في تلت مناطق مهمة جدا
+
+190
+00:16:29,520 --> 00:16:33,520
+تلت characteristic feature sorry مهمة جدا اما واحد
+
+191
+00:16:33,520 --> 00:16:42,580
+ان ال polar or chart side ال chain بتكون برا وهذه
+
+192
+00:16:42,580 --> 00:16:50,480
+بتؤكد على انهعلى ان الموليكيول هيدروفوبك وبالتالي
+
+193
+00:16:50,480 --> 00:16:57,940
+صليبل بينما ال non polar بتكون روابط داخلية وهذا
+
+194
+00:16:57,940 --> 00:17:02,900
+يعني على ان الموليكيول من جوا هو هيدروفوبك مابده
+
+195
+00:17:02,900 --> 00:17:06,980
+ميه تخش جوا وبالتالي بدهش يتأكسد من جوا
+
+196
+00:17:11,030 --> 00:17:15,510
+الـ Heme Bucket is created بيصير فيه Opened Top
+
+197
+00:17:15,510 --> 00:17:21,610
+Left للموليكيول بنفتح من هنا و بيصير فيه إيش الـ
+
+198
+00:17:21,610 --> 00:17:24,890
+Heme Bucket due بالهيم موجودة في الـ Tertiary
+
+199
+00:17:24,890 --> 00:17:31,590
+Structure و طبعا الـ Due بالهيم موجدت عشان شغلتين
+
+200
+00:17:31,590 --> 00:17:38,510
+شغل أولانية عشان تحمل ال Oxygen في جواتها نمرا
+
+201
+00:17:38,510 --> 00:17:43,540
+اتنين عشان تتضمنتحت حماية الـ Ferrous-Ion اللي
+
+202
+00:17:43,540 --> 00:17:48,420
+موجودة في داخل الـGlobin.نبغى تلاتة الـAmino Acid
+
+203
+00:17:48,420 --> 00:17:56,180
+اللي موجود سواء كان Inter-Subunit Bonding مسئول عن
+
+204
+00:17:56,180 --> 00:18:00,020
+الـQuaternary Structure اللي بدأت تكون بعد ذلك
+
+205
+00:18:00,020 --> 00:18:05,320
+وهذا الـQuaternary Structure والـQuaternary
+
+206
+00:18:05,320 --> 00:18:11,750
+Structure of Hemoglobin له أربع Subunitsمرتبة في
+
+207
+00:18:11,750 --> 00:18:17,550
+الـ hemoglobin A بشكل القاتل المراوحة بتتكون روابط
+
+208
+00:18:17,550 --> 00:18:22,810
+Alpha 1 Beta 1 أو Alpha 2 Beta 2 وهذه روابط قوية
+
+209
+00:18:22,810 --> 00:18:28,470
+مسؤولة عن stability of the molecule بتشكل حوالي
+
+210
+00:18:28,470 --> 00:18:32,910
+تشترك في تكوينها حوالي 30 amino acidsبينما الروابط
+
+211
+00:18:32,910 --> 00:18:37,370
+التانية Alpha-1 Beta-2 Alpha-2 Beta-1 وهذه تقوم
+
+212
+00:18:37,370 --> 00:18:41,290
+بإعادة الـ Solubility روابط الأمينواسد التي تشترك
+
+213
+00:18:41,290 --> 00:18:44,710
+فيها حوالي عشرين أمينواسد وأخر واحدة Alpha-1
+
+214
+00:18:44,710 --> 00:18:49,230
+بAlpha-2 Beta-1 Beta-2 وهذه أضعفهم، أضعف الروابط
+
+215
+00:18:49,230 --> 00:18:52,670
+لأنه مسئول عن تعمل ال Oxygenation وDeoxygenation
+
+216
+00:18:52,670 --> 00:18:59,050
+وبالتالي مقموض منها أنها تفتح وتتسكر Function of
+
+217
+00:18:59,050 --> 00:19:04,640
+Hemoglobinبتعرف انه Oxygen delivery to the tissue
+
+218
+00:19:04,640 --> 00:19:10,000
+وطبيعة التفاعل ما بين ال Hemoglobin و ال Oxygen
+
+219
+00:19:10,000 --> 00:19:14,300
+بيعتمد على ال Oxygen نفسي Oxygenation و ليس
+
+220
+00:19:14,300 --> 00:19:18,140
+Oxidation Oxygenation يعني حمل الأكسجين و ليس
+
+221
+00:19:18,140 --> 00:19:24,230
+أكسدة ال Hemoglobin يعني مش تفاعل كيميائينمرة
+
+222
+00:19:24,230 --> 00:19:28,810
+اتنين كل لن هيموجلوبين برتبط باربع ذرات من
+
+223
+00:19:28,810 --> 00:19:35,530
+الأكسجين نمرة تلاتة عملية ال Oxygenation لا تتعدى
+
+224
+00:19:35,530 --> 00:19:41,050
+ال point O one second يعني بس يخش الهيموجلوبين على
+
+225
+00:19:41,050 --> 00:19:45,690
+اللان يصير فيه Oxygenation للهيموجلوبين عملية ال
+
+226
+00:19:45,690 --> 00:19:48,190
+Oxygenation بتتم من خلال تباعد
+
+227
+00:19:50,490 --> 00:19:53,890
+حركة الموليكيوسوري وجدوا انه يوم ما يصير فيه
+
+228
+00:19:53,890 --> 00:20:00,170
+Oxygenation بيصير فيه Beta Chain Closing يعني ال
+
+229
+00:20:00,170 --> 00:20:04,670
+Beta Chain بتقرب على بعض و يوم ما تقرب على بعض ال
+
+230
+00:20:04,670 --> 00:20:10,130
+heme بوكت مفتحه فبخش ال Oxygen في داخل ال heme يوم
+
+231
+00:20:10,130 --> 00:20:16,330
+ما تبعد ال Beta Chain عن بعض ماشي أرض أرض يعني
+
+232
+00:20:16,870 --> 00:20:21,610
+بيصير فيه ضغط على الـ hem pocket فبتطلع ال oxygen
+
+233
+00:20:21,610 --> 00:20:26,050
+اللي في جلبها عشان هيك بيصير في oxygen unloading
+
+234
+00:20:26,050 --> 00:20:30,650
+وفي نفس الوقت في مركب اسمه 23dbg
+
+235
+00:20:30,650 --> 00:20:36,030
+-diphosphoglycerate هو اللي بيدخل في داخل ال
+
+236
+00:20:36,030 --> 00:20:41,430
+hemoglobin موليكيوم وبالتالي بيعتبر ال 23dbg منافس
+
+237
+00:20:41,430 --> 00:20:49,700
+لأكسجين في دخوله
+
+238
+00:20:49,700 --> 00:20:55,000
+إلى الـ Hemoglobin أو تحميل الـ Hemoglobin فهذه
+
+239
+00:20:55,000 --> 00:20:59,380
+الصورة كما تشاهدون هي الـ Hembucket فاتحة فالـ
+
+240
+00:20:59,380 --> 00:21:06,380
+Oxygen داخلها و هذا معناته ان الـ Beta Chain جربت
+
+241
+00:21:06,380 --> 00:21:10,020
+على بعض سكرت
+
+242
+00:21:10,020 --> 00:21:11,740
+يعني ففتحت الـ Hembucket
+
+243
+00:21:18,430 --> 00:21:25,110
+الهيمبوك تباعد عن بعضها تباعد عن بعضها تباعد عن
+
+244
+00:21:25,110 --> 00:21:32,010
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+245
+00:21:32,010 --> 00:21:33,970
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+246
+00:21:33,970 --> 00:21:36,110
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+247
+00:21:36,110 --> 00:21:40,940
+تباعد عن بعضها تبمشي طلعت فضت الجوايه الجيوب ال
+
+248
+00:21:40,940 --> 00:21:45,800
+oxygen اللي في جلبها ومين دخل دخل 23dbg في النص
+
+249
+00:21:45,800 --> 00:21:53,280
+صار الهمoglobin دي oxygenated معروف
+
+250
+00:21:53,280 --> 00:21:58,780
+ان ال normal hemoglobin في كل gram منه بيرتبط ب 1
+
+251
+00:21:58,780 --> 00:22:03,940
+.34 ميلي من ال oxygen يعني واحد عنده hemoglobin 14
+
+252
+00:22:03,940 --> 00:22:09,950
+gram تقريبا بيحملعشرين مل من الأكسجين عشرين مل من
+
+253
+00:22:09,950 --> 00:22:13,590
+ال .. بتحمل بعشرين مل من الأكسجين تقريبا تسعت عشر
+
+254
+00:22:13,590 --> 00:22:18,270
+نص لأنه ما بيصيرش complete اللي هو loading
+
+255
+00:22:18,270 --> 00:22:23,670
+للأكسجين ال degree of saturation تعتبد على ال
+
+256
+00:22:23,670 --> 00:22:30,070
+oxygen tension و كلنا بنعرف أن بغض الأكسجين في ال
+
+257
+00:22:30,070 --> 00:22:34,450
+lung حوالي نيت ملي متر ذئبق بينما في ال tissue
+
+258
+00:22:35,150 --> 00:22:38,750
+حوالي خمسة و تلاتين ملي متر زي ابقى فالفرق في
+
+259
+00:22:38,750 --> 00:22:42,990
+الضغط بحد ذاته كمان هو عامل من الهوامل انه يصير
+
+260
+00:22:42,990 --> 00:22:48,930
+عملية تعباية او تفضاية لل Hemoglobin العملية هذه
+
+261
+00:22:48,930 --> 00:22:54,410
+مثلوها رياضيا ال curve سموه oxygen dissociation
+
+262
+00:22:54,410 --> 00:22:59,730
+curve of Hemoglobin و قالوا ان من صفاته
+
+263
+00:23:02,260 --> 00:23:05,880
+إنه بيعكس ال properties of hemoglobin itself
+
+264
+00:23:05,880 --> 00:23:15,160
+وقالوا إنه بيتأثر بعوامل عدة هذي العوامل لاتؤثر
+
+265
+00:23:15,160 --> 00:23:19,980
+على شكل ال curve وإنما تؤثر على موقع ال curve
+
+266
+00:23:19,980 --> 00:23:27,460
+فبتحرك ال curve إما يمينا وإما يسارا طبعا هي و كما
+
+267
+00:23:27,460 --> 00:23:30,180
+تشوفون العلاقة ما بين ال lung و ال tissue في ال
+
+268
+00:23:30,180 --> 00:23:35,160
+lung ده هوبتحمل الهيموجلوبين بالأكسجين و لما بروح
+
+269
+00:23:35,160 --> 00:23:38,560
+اتشه بصير فيه release للهيموجلوبين للأكسجين من
+
+270
+00:23:38,560 --> 00:23:42,080
+الهيموجلوبين و مش بس release بتحمل بساني اكسي
+
+271
+00:23:42,080 --> 00:23:44,640
+الكربون برجع تاني على ال lung و هناك بصير فيه
+
+272
+00:23:44,640 --> 00:23:50,780
+release ل ال CO2 to the lung وهي ال normal
+
+273
+00:23:50,780 --> 00:23:53,800
+hemoglobin oxygen dissociation curve اللي هو
+
+274
+00:23:53,800 --> 00:23:57,720
+الأزرق هذا هو اللي في النص وقولنا في بعض العوامل
+
+275
+00:23:57,720 --> 00:24:02,380
+اللي بتؤثر على موقع ال curveفإما يأتي على اليمين
+
+276
+00:24:02,380 --> 00:24:07,460
+أو يذهب إلى الشمال لكن شكل الكيرب يبقى كما هو فإما
+
+277
+00:24:07,460 --> 00:24:14,020
+يصبح الهيموجلبي right shifted أو left shifted بس
+
+278
+00:24:14,020 --> 00:24:20,220
+يجب أن ناخد في هذا الاعتبار أنه عند 50% تقريبا أو
+
+279
+00:24:20,220 --> 00:24:26,060
+40% الهيموجلبي
+
+280
+00:24:26,060 --> 00:24:27,500
+تشوفوا لحظه
+
+281
+00:24:30,380 --> 00:24:34,380
+الضغط اكسوجين 40% اللي هو في ال tissue بيكون ال
+
+282
+00:24:34,380 --> 00:24:42,040
+hemoglobin محمل فقط ب 75% من ال oxygen و طب البذل
+
+283
+00:24:42,040 --> 00:24:45,460
+راح في ال tissue صار releasing في ال tissue ففي كل
+
+284
+00:24:45,460 --> 00:24:52,260
+مرة ال hemoglobin لما دخل ال tissue ينزل حوال 12%
+
+285
+00:24:52,260 --> 00:24:58,120
+من اللي هو ال oxygen
+
+286
+00:25:04,190 --> 00:25:06,810
+ما هي العاملة اللى بتعمل اللى بتغير على شكل اللى
+
+287
+00:25:06,810 --> 00:25:09,730
+هو موقع ال Hemoglobin Oxygen Dissociation Care
+
+288
+00:25:09,730 --> 00:25:13,790
+اللى عامل Hemoglobin Variant نوعه انا هسوي مثال
+
+289
+00:25:13,790 --> 00:25:20,500
+Hemoglobin S هناماشى و ال decrease of oxygen
+
+290
+00:25:20,500 --> 00:25:27,340
+affinity و ال pH لما بتقل ال acidity و يوم يكون ال
+
+291
+00:25:27,340 --> 00:25:30,200
+2 3 D بيجي عالى بيكون ال CO2 عالى ال antimicrobial
+
+292
+00:25:30,200 --> 00:25:38,480
+عالية بيصير في shift ال curve to the rightماشي وده
+
+293
+00:25:38,480 --> 00:25:41,500
+وده فبيعني ان هذا الظروف اللي جعلنا نحكي عنها هي
+
+294
+00:25:41,500 --> 00:25:44,840
+عبارة عن ظروف بتصير فيهاش في ال tissue ففي ال
+
+295
+00:25:44,840 --> 00:25:48,980
+tissue بتصير في unloading يعني بتقل ال affinity of
+
+296
+00:25:48,980 --> 00:25:52,320
+Hemoglobin to bind with Oxygen فبتصير في releasing
+
+297
+00:25:52,320 --> 00:25:58,620
+unloading يعني ماشي وعلى العكس من ذلك يوم يكون في
+
+298
+00:25:58,620 --> 00:26:03,560
+Hemoglobin variant تاني زي Hemoglobin F انه له
+
+299
+00:26:03,560 --> 00:26:07,590
+high affinity to Oxygenبتزيد ال affinity يوم يكون
+
+300
+00:26:07,590 --> 00:26:15,650
+زيادة في ال pH ماشي DBG قليل PCO2 قليل or
+
+301
+00:26:15,650 --> 00:26:20,270
+temperature is low بيصير في high affinity of two
+
+302
+00:26:20,270 --> 00:26:26,430
+oxygen وبالتالي بيصير shifting to the left وهي ال
+
+303
+00:26:26,430 --> 00:26:30,710
+hemoglobin oxygen dissociation curve وهي العوامل
+
+304
+00:26:30,710 --> 00:26:32,530
+اللي بتودي هيك و بتودي هيك
+
+305
+00:26:37,200 --> 00:26:44,040
+الهيموغلبن عادى ان يتعامل
+
+306
+00:26:44,040 --> 00:26:45,240
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+307
+00:26:45,240 --> 00:26:46,820
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+308
+00:26:46,820 --> 00:26:47,040
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+309
+00:26:47,040 --> 00:26:47,240
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+310
+00:26:47,240 --> 00:26:48,340
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+311
+00:26:48,340 --> 00:26:51,780
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بش
+
+312
+00:26:55,870 --> 00:27:02,330
+طبعا هذا الكلام بيحصل يوم يكون الضغط الأكسجين هو
+
+313
+00:27:02,330 --> 00:27:08,910
+27.1% و 27.5% في الفتاة وبالتالي
+
+314
+00:27:08,910 --> 00:27:11,990
+وإذا أزداد مرتبط الأكسجين الـ dissociation curve
+
+315
+00:27:11,990 --> 00:27:16,750
+is shifted leftward and value is reduced وإذا
+
+316
+00:27:16,750 --> 00:27:17,730
+أزداد مرتبط الأكسجين الـ Conversely decreased
+
+317
+00:27:17,730 --> 00:27:21,290
+oxygen affinity ال curve بيصير على ال right الكلام
+
+318
+00:27:21,290 --> 00:27:22,090
+هذا حاجة نحتوي
+
+319
+00:27:25,060 --> 00:27:27,960
+هذه العوامل اللي بتؤثر على ال oxygen dissociation
+
+320
+00:27:27,960 --> 00:27:35,380
+curve وهذه اللي بتعمله left shifting وهذه بتعمل
+
+321
+00:27:35,380 --> 00:27:41,120
+right shifting وهذه التانتين ونبدأ بأول هذه
+
+322
+00:27:41,120 --> 00:27:44,780
+العوامل وهي ال power effect يا بناته يا شباب
+
+323
+00:27:44,780 --> 00:27:50,660
+افهموني ال power effect يعني دور ال pH في علاقته
+
+324
+00:27:50,660 --> 00:27:55,720
+بال oxygen affinityببساطة الهيموجلوب ال oxygen
+
+325
+00:27:55,720 --> 00:28:01,920
+affinity is reduced كل مكان ال acidity اكتر طب
+
+326
+00:28:01,920 --> 00:28:06,720
+وكتيرش بيكون في acidity لما يكون الهيموجلوب يفتشه
+
+327
+00:28:06,720 --> 00:28:10,500
+يعني فتشه بزيد ال acidity طبعا مش بيصير في
+
+328
+00:28:10,500 --> 00:28:19,160
+metabolism ومحصلة ال metabolic pathway هي تكونالـ
+
+329
+00:28:19,160 --> 00:28:23,460
+Lactate أو الـ Lactic أسد الـ Formation وCO2
+
+330
+00:28:23,460 --> 00:28:26,300
+والتاني يكونوا Hydrochloric أدلة هو Carbonic أسد
+
+331
+00:28:26,300 --> 00:28:30,320
+والتاني عبارة عن أسدك Medium فبالتالي في ال tissue
+
+332
+00:28:30,320 --> 00:28:36,920
+ال oxygen affinity is decreased مين أثر عليها؟ ال
+
+333
+00:28:36,920 --> 00:28:44,070
+pH شو كان في دور ال pH؟ أسدك طبعا هذا الكلامبيكون
+
+334
+00:28:44,070 --> 00:28:52,410
+عكسه موجود في الـ Lung بيكون
+
+335
+00:28:52,410 --> 00:28:55,710
+عكسه موجود في الـ Lung بيكون عكسه موجود في الـ
+
+336
+00:28:55,710 --> 00:28:57,750
+Lung بيكون عكسه موجود في الـ Lung بيكون عكسه موجود
+
+337
+00:28:57,750 --> 00:28:59,350
+في الـ Lung بيكون عكسه موجود في الـ Lung بيكون
+
+338
+00:28:59,350 --> 00:29:00,270
+عكسه موجود في الـ Lung بيكون عكسه موجود في الـ
+
+339
+00:29:00,270 --> 00:29:00,370
+Lung بيكون عكسه موجود في الـ Lung بيكون عكسه موجود
+
+340
+00:29:00,370 --> 00:29:06,940
+في الـ Lدور الـ 2,3-DBG، وما هو الـ 2,3-DBG؟ قالوا
+
+341
+00:29:06,940 --> 00:29:09,880
+إن هذا عبارة عن مُركّب أحد نواتج الـ glycolytic
+
+342
+00:29:09,880 --> 00:29:16,040
+pathway اللي موجودة في الـ RBCs وين بتصنع في أي
+
+343
+00:29:16,040 --> 00:29:20,540
+جزء غيره، بتصنع في جزء الرابع بوصوله برينشان، وش
+
+344
+00:29:20,540 --> 00:29:26,520
+بصير؟ بتصنع الـ 2,3-DBG في الـ glycolytic pathway،
+
+345
+00:29:26,520 --> 00:29:30,180
+طيب، إيش اللي بصير؟ احنا بنحكي glycolytic pathway
+
+346
+00:29:30,690 --> 00:29:35,110
+يعني عمال ما بيحكي على طاقة، إنتاج طاقة وكأحد
+
+347
+00:29:35,110 --> 00:29:38,790
+المخلفات اللي بتنتج الـ 2,3-DPG اللي يوم ما ..
+
+348
+00:29:38,790 --> 00:29:44,090
+وكدهش محتاج الطاقة، فتشهر فتشهر و تزيد اللي هو الـ
+
+349
+00:29:44,090 --> 00:29:48,250
+glycolytic activity فمزيد الـ 2,3-DPG ويوم ما يزيد
+
+350
+00:29:48,250 --> 00:29:52,830
+الـ 2,3-DPG قلنا هو عبارة عن منافس قوي لمين للـ
+
+351
+00:29:52,830 --> 00:29:56,850
+Hemoglobin في ارتباطه بالأكسجين فبيطلع الأكسجين،
+
+352
+00:29:56,850 --> 00:30:01,090
+بيعمل unloading للأكسجين و بيخش محل إلهاجفي نص الـ
+
+353
+00:30:01,090 --> 00:30:07,170
+Hemoglobin وبالتالي يوم يزيد الـ 2,3-DBG بيقل الـ
+
+354
+00:30:07,170 --> 00:30:12,910
+Oxygen loading بيصير Unloading بينجوسين بتقل ال
+
+355
+00:30:12,910 --> 00:30:19,270
+Affinity to Oxygen وبزيد ال Release وهي الـ 2,3
+
+356
+00:30:19,270 --> 00:30:25,350
+-DBG هي هذا اللي في النص Normal يوم زاد صار يوم قل
+
+357
+00:30:25,350 --> 00:30:27,030
+صار
+
+358
+00:30:29,700 --> 00:30:40,520
+صار سفر فوق في ال tissue اللي هو ال oxygen بي
+
+359
+00:30:40,520 --> 00:30:44,880
+بي جي بي بي جي بي بي بي بي بي بي بي بي بي بي بي بي
+
+360
+00:30:44,880 --> 00:30:46,460
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+361
+00:30:46,460 --> 00:30:47,300
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+362
+00:30:47,300 --> 00:30:47,420
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+363
+00:30:47,420 --> 00:30:53,520
+بي
+
+364
+00:30:53,520 --> 00:30:55,840
+ب
+
+365
+00:30:57,630 --> 00:31:01,510
+لما صار تمانية يعني زاد صار فيه قلة في ال oxygen
+
+366
+00:31:01,510 --> 00:31:08,170
+affinity وبالتالي shift to the right لما ال ox
+
+367
+00:31:08,170 --> 00:31:15,910
+hemoglobin stride of 23 dbg قل
+
+368
+00:31:15,910 --> 00:31:20,590
+فصار زيادة في ال oxygen affinity وبالتالي اتحمل ده
+
+369
+00:31:20,590 --> 00:31:24,110
+و shift to the left ماشي مرة تانية اللي في النص
+
+370
+00:31:24,110 --> 00:31:29,300
+normalHemoglobin L23dBG هو خمسة ملي مول per liter
+
+371
+00:31:29,300 --> 00:31:35,460
+لما زاد وصل ل تمانية ايه الكيروف ايه الكيروف صار
+
+372
+00:31:35,460 --> 00:31:39,800
+على اليمين لما قلت L23dBG صار الكيروف على الشمال
+
+373
+00:31:39,800 --> 00:31:44,040
+لاننا نعرف ان الكيروف لما يسير على اليمين يعني ال
+
+374
+00:31:44,040 --> 00:31:49,720
+affinity بتقل و ال release بزيد و لما بسير نروح
+
+375
+00:31:49,720 --> 00:31:56,730
+على الشمالالـ Affinity بتزيد والـ Release بقل وهى
+
+376
+00:31:56,730 --> 00:31:59,870
+زى ما قلتلكوا وين بتصنع هذى ال glycolytic pathway
+
+377
+00:31:59,870 --> 00:32:03,010
+كله ال glycolytic pathway طبعا ليش؟ طبعا العربيسيز
+
+378
+00:32:03,010 --> 00:32:06,930
+وان شاء الله هنتطرق اليه ب .. اللى هي مولتكاليميا
+
+379
+00:32:06,930 --> 00:32:10,510
+قدام زى ما انتوا شايفين بيتكون من تلت أجزاء أساسية
+
+380
+00:32:10,510 --> 00:32:15,590
+الأولاني هذا هو الرئيسي ال glucose بتحول لمين؟ ل
+
+381
+00:32:15,590 --> 00:32:20,840
+Lactate او Lactic Acidوبتصنع في هذه العملية بيتكون
+
+382
+00:32:20,840 --> 00:32:26,760
+تلاتة ATP ثم في two شنط هي واحدة و هي واحدة الشنط
+
+383
+00:32:26,760 --> 00:32:30,040
+الألمانية بيسموها Pentose Phosphate شنط وكل اللي
+
+384
+00:32:30,040 --> 00:32:34,900
+بتصنع فيها الناد BH اللي مطلوب for reduction of
+
+385
+00:32:34,900 --> 00:32:43,320
+oxygen وشنط التانية ذي رابابورت لبريان شنط ذي ان
+
+386
+00:32:43,320 --> 00:32:47,860
+بيتكون فيها two 3 DBG ماشي واحدة قولنا منافس قوي
+
+387
+00:32:47,860 --> 00:32:51,320
+لميه؟للهيموجلوبين للأكسجين في ارتباطه
+
+388
+00:32:51,320 --> 00:32:55,720
+بالهيموجلوبين دي
+
+389
+00:32:55,720 --> 00:33:00,520
+اللي هو كيف يتكوّل الأيام
+
+390
+00:33:00,520 --> 00:33:04,400
+يكون ال oxygen is unloaded with hemoglobin by
+
+391
+00:33:04,400 --> 00:33:09,440
+hemoglobin 23DPG بيكون داخل ال hemoglobin وبيسمو
+
+392
+00:33:09,440 --> 00:33:12,520
+ال hemoglobin molecule في هذه الحالة tense form
+
+393
+00:33:12,520 --> 00:33:18,140
+tense form ليش؟ لإن هو فاض أو فضةاللي مجلد محمل
+
+394
+00:33:18,140 --> 00:33:24,440
+الـ 2,3-dBG المحصلة الـ Affinity to Oxygen is
+
+395
+00:33:24,440 --> 00:33:29,580
+lowered ولمّا يكون العكس الـ 2,3-dBG is expelled
+
+396
+00:33:29,580 --> 00:33:36,840
+out زاد الـ Oxygen Affinity الـ PO2 Pressure of
+
+397
+00:33:36,840 --> 00:33:40,900
+Oxygen وهذا بزيد في الـ Lung الـ 2,3-dBG بيصل الـ
+
+398
+00:33:40,900 --> 00:33:45,880
+Expelling outوالهيموجلبل بتحمل بالأكسجين وبيسموه
+
+399
+00:33:45,880 --> 00:33:49,640
+ال relaxed form وفي هذا الحال ال affinity to
+
+400
+00:33:49,640 --> 00:33:54,440
+oxygen is high وهذه العملية ما بتحول الهيموجلبل من
+
+401
+00:33:54,440 --> 00:33:58,080
+tense to relax تينس توريلاكس تينس توريلاكس تينس
+
+402
+00:33:58,080 --> 00:33:59,700
+توريلاكس تينس توريلاكس تينس توريلاكس تينس توريلاكس
+
+403
+00:33:59,700 --> 00:34:02,220
+تينس توريلاكس تينس توريلاكس تينس توريلاكس تينس
+
+404
+00:34:02,220 --> 00:34:05,360
+توريلاكس تينس
+
+405
+00:34:05,360 --> 00:34:09,120
+توريلاكس
+
+406
+00:34:09,120 --> 00:34:14,060
+تينس توريلاكability of hemoglobin to bind to 2,3
+
+407
+00:34:14,060 --> 00:34:17,940
+-DBG وهذا الكلام بيحصل في الـ fetal hemoglobin الـ
+
+408
+00:34:17,940 --> 00:34:22,520
+fetal hemoglobin ما عنده القدرة على الارتباط بالـ
+
+409
+00:34:22,520 --> 00:34:26,900
+2,3-DBG فبيضل محمل بقاش بالأكسجين وبالتالي ال
+
+410
+00:34:26,900 --> 00:34:33,620
+affinity to oxygen is high 2
+
+411
+00:34:33,620 --> 00:34:36,640
+,3-DBG concentration يتأثر بعدة عوامل منها على
+
+412
+00:34:36,640 --> 00:34:41,670
+سبيل المثال الhypoxia فجاله في حالات الhypoxiaبصير
+
+413
+00:34:41,670 --> 00:34:50,810
+فيه زيادة في تركيز الـ 2,3 dBG والـ Oxygen
+
+414
+00:34:50,810 --> 00:34:59,130
+Affinity بتقل كمان ال delivery of oxygen
+
+415
+00:34:59,130 --> 00:35:01,410
+to tissue is facilitating
+
+416
+00:35:04,240 --> 00:35:07,880
+على سبيل المثال في بعض حالات الـ Hypoxia زي الـ
+
+417
+00:35:07,880 --> 00:35:10,600
+High Attitude و الـ Anoxia و الـ Pulmonary or
+
+418
+00:35:10,600 --> 00:35:14,500
+Cardiac Disease or Blood Loss or Anemia ماشي هذا
+
+419
+00:35:14,500 --> 00:35:22,860
+الكلام بيصير to 3D بيجي بيصير له زيادة
+
+420
+00:35:22,860 --> 00:35:26,640
+و يوم ما يزيد بقعد في ال Oxygen فبالتالي ال
+
+421
+00:35:26,640 --> 00:35:29,440
+Affinity to Oxygen بيقعد في ال Hemoglobin فبالتالي
+
+422
+00:35:29,440 --> 00:35:32,840
+ال Affinity to Oxygen بتقل و Release of Oxygen
+
+423
+00:35:32,840 --> 00:35:37,330
+كمان بتقلوهذا نوع من ال adaptation نوع من ال
+
+424
+00:35:37,330 --> 00:35:42,090
+adaptation الزيادة في ال two three دي بيجيب تلعب
+
+425
+00:35:42,090 --> 00:35:45,230
+دور كبير في ال adaptation to exercise also يوم
+
+426
+00:35:45,230 --> 00:35:50,010
+الواحد يجري ويفقد كميات كبيرة من أياش من اللي هو
+
+427
+00:35:50,010 --> 00:35:56,330
+الطاقةالحالة المطلوبة أن نعمل adaptation كيف يحدث
+
+428
+00:35:56,330 --> 00:35:59,050
+ال adaptation؟ نريد أن نقلل كمية ال oxygen اللي
+
+429
+00:35:59,050 --> 00:36:04,330
+نفقدها فبتدخل تركيز الدوس الريدي بيتحمل في
+
+430
+00:36:04,330 --> 00:36:07,730
+الهيموجلوبين بيقل الهيموجلوبين affinity بيتقل
+
+431
+00:36:07,730 --> 00:36:13,730
+الهيموجلوبين release عام
+
+432
+00:36:13,730 --> 00:36:16,330
+الآخر بيؤثر على الهيموجلوبين كاربون ديكسايد كاربون
+
+433
+00:36:16,330 --> 00:36:23,390
+ديكسايد طبعابفتبط الشرطبات مباشر بال Hemoglobin
+
+434
+00:36:23,390 --> 00:36:26,630
+وإنما بيصير ال diffusion في داخل ال RBCs و
+
+435
+00:36:26,630 --> 00:36:29,990
+diffusion في داخل ال Hemoglobin لكنه بيصير ال
+
+436
+00:36:29,990 --> 00:36:34,610
+diffusion بالقاتل قبل ما يصير ال Hemoglobin لو CO2
+
+437
+00:36:34,610 --> 00:36:39,510
+بيتعرض ده إيش ل two reaction أول reaction CO2 مع
+
+438
+00:36:39,510 --> 00:36:44,910
+ميا بيكوّن carbonic acid وال carbonic acid يتحول
+
+439
+00:36:44,910 --> 00:36:47,250
+إلى بيكربونيت وهيدروجين
+
+440
+00:36:51,020 --> 00:36:55,320
+ماشي أي ال carbon dioxide diffuse freely into the
+
+441
+00:36:55,320 --> 00:37:02,100
+RBCs و هذا بيشكل اللي هو أيش انه ال reaction
+
+442
+00:37:02,100 --> 00:37:07,660
+الأولاني ان ال steel H plus liberated in reaction
+
+443
+00:37:07,660 --> 00:37:12,650
+two is accepted by deoxygenated hemoglobinوهذه
+
+444
+00:37:12,650 --> 00:37:16,790
+طبعا اللي بيأثر فيها هو عبارة عن Pohar Effect الـ
+
+445
+00:37:16,790 --> 00:37:23,090
+Bicarbonate جثتها جثة بس كل ما هناك انه هي diffuse
+
+446
+00:37:23,090 --> 00:37:29,130
+freely across the red cell membrane وجزء منها
+
+447
+00:37:29,130 --> 00:37:33,890
+بيصير exchange هو ال chloride اللي موجود في
+
+448
+00:37:33,890 --> 00:37:39,870
+البلازمة بيسموها chloride shift ال bicarbonate بعد
+
+449
+00:37:39,870 --> 00:37:43,640
+ذلك بتنعمل in plasma to the lungوهناك بيصلها
+
+450
+00:37:43,640 --> 00:37:49,480
+ventilation as PCO2 is low وانا بيقدي الى ال
+
+451
+00:37:49,480 --> 00:37:56,020
+exertion او excretion of CO2 لان 70% من ال carbon
+
+452
+00:37:56,020 --> 00:38:02,240
+dioxide بيتم التخلص منه بهذه الطريقة و 30% اللي
+
+453
+00:38:02,240 --> 00:38:06,760
+دايرين 5% موجودين هنا simple solution و 25%
+
+454
+00:38:06,760 --> 00:38:09,900
+برتبطوا بال Hemoglobin و بيكونوا Carb Amino
+
+455
+00:38:09,900 --> 00:38:15,790
+Hemoglobinمت هموبلبنينيا احنا مطلوب منها ان
+
+456
+00:38:15,790 --> 00:38:21,670
+الهموبلبن يظل دائما بحالة in reduced form و
+
+457
+00:38:21,670 --> 00:38:25,650
+reduced form اللي احنا نبسط فيه ان الفرس ان ال
+
+458
+00:38:25,650 --> 00:38:30,830
+iron atom يظل in its فرس form يعني reduced form
+
+459
+00:38:30,830 --> 00:38:36,430
+لما يتأكسد الحديد يبطل عنده القدرة على ايش على
+
+460
+00:38:36,430 --> 00:38:42,810
+الارتباط بالهموبلبن او حمل الهموبلبنليه؟ عشان يكلا
+
+461
+00:38:42,810 --> 00:38:45,450
+في داخل القرعات الدم الحمراء في عدة ميكانيزم
+
+462
+00:38:45,450 --> 00:38:50,850
+مسئولة عن إيش؟ عن الحفاف بشكل دايم على ال reduced
+
+463
+00:38:50,850 --> 00:38:55,790
+form of hemoglobinوقت ايش بيحصل في مت-همoglobin؟
+
+464
+00:38:55,790 --> 00:38:58,930
+قالوا فيه تلات حالات الحال الأولانية إذا كان ال
+
+465
+00:38:58,930 --> 00:39:02,330
+RBCs is exposed to certain oxidant و لا كله مابخش
+
+466
+00:39:02,330 --> 00:39:05,910
+اكسيدان المطلوب من ال RBCs انه يخلصنا من ال
+
+467
+00:39:05,910 --> 00:39:10,870
+oxidant أول بول نمرة اتنين إذا كان ال intrinsic
+
+468
+00:39:10,870 --> 00:39:13,450
+protective mechanism اللي هو الميكانيزم الداخلي
+
+469
+00:39:13,450 --> 00:39:18,190
+هذا خرب اللي بيحافظ على ال reduced form نمرة تلاتة
+
+470
+00:39:18,190 --> 00:39:21,370
+إذا كان فيه genetic abnormality؟ قالوا في بعض
+
+471
+00:39:21,370 --> 00:39:22,570
+النوع من ال hemoglobin
+
+472
+00:39:25,190 --> 00:39:31,370
+بـaffected اللي هو global stability أو اللي هو الـ
+
+473
+00:39:31,370 --> 00:39:34,690
+hemoglobin طبعا هذه أدولة صورتين الصورة هذه عبارة
+
+474
+00:39:34,690 --> 00:39:38,310
+عن ميكانيزم تبع الـ Intrapascular Hemolysis وزي ما
+
+475
+00:39:38,310 --> 00:39:40,990
+أنتوا شايفين أنا مش راح أخد فيها هتاخدها في ال
+
+476
+00:39:40,990 --> 00:39:45,770
+clinical chemistry بالتفصيل في ال Intrapascular
+
+477
+00:39:45,770 --> 00:39:49,090
+Hemolysis تسر قوة الدم الحوراء و بزيد ال بالروبين
+
+478
+00:39:49,450 --> 00:39:52,190
+بقل الـ Heptoglobin الـ Heptoglobin هو عبارة عن
+
+479
+00:39:52,190 --> 00:39:58,390
+Hemoglobin Carrier Compound فلما بيزيد الـ
+
+480
+00:39:58,390 --> 00:40:00,950
+Hemoglobin اللي طالع من داخل الخضرية مرتبط بالـ
+
+481
+00:40:00,950 --> 00:40:03,510
+Heptoglobin فبقل الـ Hemoglobin الـ Heptoglobin
+
+482
+00:40:03,510 --> 00:40:09,290
+تركيزا ماشي و بضل فدي عندنا Free Hemoglobin موجود
+
+483
+00:40:09,290 --> 00:40:12,790
+برضه و ايضا الـ Extravascular زي ما انتوا شايفين
+
+484
+00:40:12,790 --> 00:40:16,370
+هاي ال Hemoglobin بتكسر شره Hemoglobin اللي ناخد
+
+485
+00:40:16,370 --> 00:40:22,110
+من ال Iron بضل Globinهو بيظل اللي هو ال .. ال ..
+
+486
+00:40:22,110 --> 00:40:22,950
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+487
+00:40:22,950 --> 00:40:23,310
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+488
+00:40:23,310 --> 00:40:23,370
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+489
+00:40:23,370 --> 00:40:24,130
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+490
+00:40:24,130 --> 00:40:25,910
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+491
+00:40:25,910 --> 00:40:26,230
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+492
+00:40:26,230 --> 00:40:31,410
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+493
+00:40:31,410 --> 00:40:32,270
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+494
+00:40:32,270 --> 00:40:32,350
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+495
+00:40:32,350 --> 00:40:36,330
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+496
+00:40:36,330 --> 00:40:43,350
+ال .. ال .. ال .. ال .. ال
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..5e89f0ecdcf8d4674d8f5eb79baeac4ced7ffbc4
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/0ipY6gmGuxU_raw.srt
@@ -0,0 +1,2040 @@
+1
+00:00:01,820 --> 00:00:06,220
+بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوقع و
+
+2
+00:00:06,220 --> 00:00:10,100
+نجمعين اليوم ان شاء الله هنشتغل او هنتكلم في
+
+3
+00:00:10,100 --> 00:00:17,980
+المحاضرة رقم 4 اللي بتحكي عن ال hemoglobin
+
+4
+00:00:17,980 --> 00:00:21,120
+synthesis structure and function
+
+5
+00:00:28,590 --> 00:00:32,650
+طيب هذه الصورة بتبين اللي هو ال structure of
+
+6
+00:00:32,650 --> 00:00:37,150
+Hemoglobin وزي ما انتوا شايفين ال Hemoglobin
+
+7
+00:00:37,150 --> 00:00:42,230
+بيتكوّن من two .. four polypeptide chain تنتين
+
+8
+00:00:42,230 --> 00:00:45,570
+Alpha وتنتين Beta وكل واحدة من ال polypeptide
+
+9
+00:00:45,570 --> 00:00:52,370
+chain مرتبطة بهم موليكيول مرتبطة بهم موليكيول
+
+10
+00:00:52,370 --> 00:00:55,450
+وبالتالي فينا four globin
+
+11
+00:00:57,020 --> 00:01:04,720
+مع فور هيم و ال normal hemoglobin بيعتبر هو عبارة
+
+12
+00:01:04,720 --> 00:01:08,180
+عن ال hemoglobin اللي له two dissimilar globin
+
+13
+00:01:08,180 --> 00:01:14,040
+chainintroduction طبعا الهيموجلوبين هو برعنة أه
+
+14
+00:01:14,040 --> 00:01:16,680
+red globular protein which have molecular weight
+
+15
+00:01:16,680 --> 00:01:23,220
+64500 الهيموجلوبين بيشكلوا تلت وزن الخلية ووظيفته
+
+16
+00:01:23,220 --> 00:01:26,640
+الأساسية هي نقل ال oxygen من ال lung لل tissue
+
+17
+00:01:26,640 --> 00:01:31,000
+واللي اليوم نعرف حوالي أكتر من 500 different
+
+18
+00:01:31,000 --> 00:01:35,600
+hemoglobin variant كلهم يلهم نفس ال structure لكن
+
+19
+00:01:35,600 --> 00:01:38,960
+اللي بدنا ناخده في عين الاعتبار أنه ال normal
+
+20
+00:01:38,960 --> 00:01:43,530
+hemoglobinnormal functioning hemoglobin هو عبارة
+
+21
+00:01:43,530 --> 00:01:47,010
+عن الـ hemoglobin اللي بيحتوي أو بيتكوّن من two
+
+22
+00:01:47,010 --> 00:01:52,210
+pairs of dissimilar globin chain نبدأ بال
+
+23
+00:01:52,210 --> 00:01:57,810
+hemoglobin synthesis أول جزء من المحاضرة و طبعا
+
+24
+00:01:57,810 --> 00:02:00,830
+كلكم بتعرف ان ال hemoglobin بيتكوّن من hemoglobin
+
+25
+00:02:00,830 --> 00:02:06,790
+و كل واحد بيتصنع في منطقة أو في لألة واحدة في
+
+26
+00:02:06,790 --> 00:02:15,360
+developing RBCsdeveloping red cell precursor وعشان
+
+27
+00:02:15,360 --> 00:02:21,580
+يطلع الـ hemoglobin بكمياته الطبيعية لابد من أن
+
+28
+00:02:21,580 --> 00:02:28,440
+يكون في coordination يعني توازي في ال hemoglobin
+
+29
+00:02:28,440 --> 00:02:33,720
+assembly hemoglobin assembly
+
+30
+00:02:38,880 --> 00:02:44,920
+تبدأ بالـ Heme Synthesis وهو كما تشاهدون الفيجر
+
+31
+00:02:44,920 --> 00:02:52,320
+يمثل خطوات الـ Heme Synthesis ويبدأ أول خطواته رقم
+
+32
+00:02:52,320 --> 00:02:57,440
+1,2,3,4 بالأحمر لغاية سبعة خطوات يبدأ في الميتر
+
+33
+00:02:57,440 --> 00:03:02,590
+كندرية هذه عبارة عن الخليةالدائرة اللي في النص هي
+
+34
+00:03:02,590 --> 00:03:05,510
+عبارة عن ميتوكندرية وبره هي عبارة عن الـ cytoplasm
+
+35
+00:03:05,510 --> 00:03:10,310
+فالخطوات اللي هي متبدأ في الميتوكندرية لإنها أول
+
+36
+00:03:10,310 --> 00:03:13,990
+خطوة هي عبارة عن energy dependent process أو step
+
+37
+00:03:13,990 --> 00:03:18,370
+وبالتالي بدها ياش بدها تكون في الميتوكندرية فهي
+
+38
+00:03:18,370 --> 00:03:22,250
+عبارة عن Saxon Neon-GME مع Glycine بدينا Delta
+
+39
+00:03:22,250 --> 00:03:27,070
+-Amino-Lavoranic Acid خطوة بتعتبر rate limiting
+
+40
+00:03:27,070 --> 00:03:33,070
+steps ومن خلالها نقدر نعملControl كل العملية بتزيد
+
+41
+00:03:33,070 --> 00:03:45,250
+إذا كان فيه Iron كتير و بتقل
+
+42
+00:03:45,250 --> 00:03:53,110
+يوم ما يكون فيه Hem كتير إذا زاد ال Hem بتقل هذه
+
+43
+00:03:53,110 --> 00:03:57,690
+العمليةوهكذا بتعتبر rate limiting steps خلّينا
+
+44
+00:03:57,690 --> 00:04:03,750
+نشوفها ده هي عبارة عن ساكسيني الكونزين Aعلى دلتا
+
+45
+00:04:03,750 --> 00:04:06,830
+امينورفلانكاسيتس خطوة تانية تنين منه بيطلع على ال
+
+46
+00:04:06,830 --> 00:04:10,290
+سايتو بلازم و اتنين منه بيكونوا ال power of a
+
+47
+00:04:10,290 --> 00:04:13,690
+pilonogen اللي بتحول اليارو power of a pilonogen
+
+48
+00:04:13,690 --> 00:04:17,630
+تلاتة ثم كوبرا power of a pilonogen تلاتة اللي
+
+49
+00:04:17,630 --> 00:04:20,410
+برجع مرة تانية by unknown ميكانيزم على ال
+
+50
+00:04:20,410 --> 00:04:25,610
+mitochondria وهناك بتحول ل protoporphrin تسعة اللي
+
+51
+00:04:25,610 --> 00:04:29,050
+بتحول لprotoporphrin تسعة اللي في النهاية بخش ال
+
+52
+00:04:29,050 --> 00:04:34,200
+iron علىفي نص المليكيورو بيكون الهيمين ونبدأ نشوف
+
+53
+00:04:34,200 --> 00:04:42,340
+واحدة واحدة هذه الخطوات هذه
+
+54
+00:04:42,340 --> 00:04:46,780
+أول خطوة سكسينيدكو انزيم A مع Glycine Delta Amino
+
+55
+00:04:46,780 --> 00:04:50,920
+Avorinic Acid Synthetase Enzyme بيدينا Delta Amino
+
+56
+00:04:50,920 --> 00:04:57,220
+Avorinic Acid أو الوفيرانيد في النهاية هذه ايه؟ زي
+
+57
+00:04:57,220 --> 00:05:03,180
+ما قلتلكم EnergyDependent و الانزيم
+
+58
+00:05:03,180 --> 00:05:07,160
+دلتامينورليكاسيدسينتريتس هو المسئول عنها تعتبر
+
+59
+00:05:07,160 --> 00:05:12,360
+فيها limiting steps في تصنيع الهيم و غالبا
+
+60
+00:05:12,360 --> 00:05:15,600
+stimulated in the presence of globin sorry و
+
+61
+00:05:15,600 --> 00:05:20,580
+inhibited in the presence of free heme تعتبر
+
+62
+00:05:20,580 --> 00:05:24,500
+control هذه الخطوة control mechanism و بتحتاج إلى
+
+63
+00:05:24,500 --> 00:05:28,720
+عدة عوامل منها vitamin b6 في الرأس و copper ion
+
+64
+00:05:30,020 --> 00:05:34,760
+والـ Synthesis of Delta Amino Uric Acid Synthetase
+
+65
+00:05:34,760 --> 00:05:38,520
+is also inhibited in the presence of free heme
+
+66
+00:05:38,520 --> 00:05:44,700
+يعني كمان الإنزيم بيهيجف ودي بتعتبر فيرثال اللي هو
+
+67
+00:05:44,700 --> 00:05:48,560
+Feedback Inhibition Mechanism بقى الهيجزة نادر
+
+68
+00:05:48,560 --> 00:05:52,980
+ماركوتو مليكيول of Delta Amino Uric Acid are
+
+69
+00:05:52,980 --> 00:05:54,320
+Diamerized
+
+70
+00:05:57,010 --> 00:06:08,250
+في وجود دلتا امينو أو دلتا امينو ديهيدرتيز او
+
+71
+00:06:08,250 --> 00:06:14,510
+بيسموه ال Porphopilenogen سينتيز تمام انه
+
+72
+00:06:14,510 --> 00:06:20,430
+ديامارايز و بيكونوا ال Porphopilenogen و ال next
+
+73
+00:06:20,430 --> 00:06:24,250
+step هي تكوين ال Porphyrin ring و ال Porphyrin
+
+74
+00:06:24,250 --> 00:06:30,970
+ring هي one ringone unit of pyroring وزي ما انتوا
+
+75
+00:06:30,970 --> 00:06:36,070
+شايفين بيتكون ال euro porphyrinogen تلاتة معايا
+
+76
+00:06:36,070 --> 00:06:42,670
+اللي بيصله decarboxylase decarboxylation by
+
+77
+00:06:42,670 --> 00:06:47,610
+decarboxylase enzyme إلى cobra porphyrinogen تلاتة
+
+78
+00:06:47,610 --> 00:06:51,530
+وبعد
+
+79
+00:06:51,530 --> 00:06:57,620
+هيك ال cobra porphyrinogen تلاتةبيصير بيوكسديز
+
+80
+00:06:57,620 --> 00:07:03,720
+انزايم بيتحول ل Protoporphin 9 في الميتوكندرية
+
+81
+00:07:03,720 --> 00:07:07,660
+يعني بيخش مرة تانية عن الميتوكندرية و ال
+
+82
+00:07:07,660 --> 00:07:14,860
+Protoporphin 9 بيتحول بيض و ايضا بيوكسديز انزايم
+
+83
+00:07:14,860 --> 00:07:18,080
+الى Protoporphin 9 و هي يصار ال four parallel ring
+
+84
+00:07:18,080 --> 00:07:24,220
+تكونات ثم بعد ذلك لم يبقى الا الى ذرة الحديد انها
+
+85
+00:07:24,220 --> 00:07:29,630
+تخش في النصالبروتوبرفين 9 في نص الموليكيولو يكون
+
+86
+00:07:29,630 --> 00:07:35,250
+نقاش الهيم الانزيمي المسؤول عن هذه العملية هو
+
+87
+00:07:35,250 --> 00:07:39,550
+الferrochelatase انزايم التالي احنا مرّين عليه في
+
+88
+00:07:39,550 --> 00:07:45,270
+ال .. في ال Sidroplastic Anemia إذا فاكرين هو و ال
+
+89
+00:07:45,270 --> 00:07:48,770
+Delta Aminolucric Acid Synthetase two انزايم
+
+90
+00:07:48,770 --> 00:07:52,790
+مسؤولين عن اللي هو تصنيع الهيم
+
+91
+00:07:56,410 --> 00:08:00,290
+Globin Synthesis التاني اللي هو جزء التاني من الـ
+
+92
+00:08:00,290 --> 00:08:04,330
+Hemoglobin قالوا هذا Globin يعني جزء من البروتين
+
+93
+00:08:04,330 --> 00:08:08,090
+يعني اللي مسؤول عنه تصنيع عن تصنيعه جينات قالوا
+
+94
+00:08:08,090 --> 00:08:11,950
+غالبا في عندنا تمانية functional Globin gene
+
+95
+00:08:11,950 --> 00:08:19,250
+مسؤولين عن تصنيع two-duplicate Globin molecule
+
+96
+00:08:19,250 --> 00:08:26,070
+موجودين in two-duplicate جيني clusterبيتا لايك
+
+97
+00:08:26,070 --> 00:08:29,550
+والفا لايك البيتا لايك ال cluster موجودة على
+
+98
+00:08:29,550 --> 00:08:36,090
+كرومزوم 11 والالفا لايك على كرومزوم 16 التمن دينات
+
+99
+00:08:36,090 --> 00:08:40,850
+هدول مسؤولين عن تصنيع ست أنواع من الoglobin chain
+
+100
+00:08:40,850 --> 00:08:46,130
+او polypeptide اللي هم الفا وبيتا وجاما ودلتا
+
+101
+00:08:46,130 --> 00:08:52,280
+وإبسلون وزيتاكيف يتم الانتوجيني of globin tree
+
+102
+00:08:52,280 --> 00:08:57,240
+synthesis وهذه مهمة صحية طبعا بيتم تصنيع الجلوبين
+
+103
+00:08:57,240 --> 00:09:08,320
+حسب اللي هو المراحل اللي بتمر فيها الجمين
+
+104
+00:09:09,330 --> 00:09:13,690
+يعني حسب مراحل تكوين الإنسان ففي الجنين على سبيل
+
+105
+00:09:13,690 --> 00:09:19,170
+المثال أول مراحل تكوينه تبدأ في اليكساك at two to
+
+106
+00:09:19,170 --> 00:09:23,930
+three weeks of gestation أول ما يبدأ يتصنع إلى الـ
+
+107
+00:09:23,930 --> 00:09:27,790
+zeta والإبسلون بلوبين chain ويكونون التنين مع بعض
+
+108
+00:09:27,790 --> 00:09:33,230
+Hemoglobin اسمه Gawar-1 زيتا إبسلون كوربتو و by
+
+109
+00:09:33,230 --> 00:09:36,630
+five weeks of gestation أيضا في اليكساك الجامع
+
+110
+00:09:36,630 --> 00:09:41,870
+والألفة تبدأ تتصنعوبصير عندنا أربعةoglobin chain
+
+111
+00:09:41,870 --> 00:09:46,510
+بتوافق والتباديل بيعملولنا كمان اتنين hemoglobin
+
+112
+00:09:46,510 --> 00:09:50,510
+واحد اسمه Portland والتاني جوار two وبالتالي بيصير
+
+113
+00:09:50,510 --> 00:09:55,090
+عندنا تلاتة أنواع من ال hemoglobin Portland زيتا
+
+114
+00:09:55,090 --> 00:10:00,890
+جامعة الكلتو و جوار اللي هو two هو عبارة عن Alpha
+
+115
+00:10:00,890 --> 00:10:07,540
+Epsilon كلتوطبعا بيبدأ زيادة الجامعة والألف على
+
+116
+00:10:07,540 --> 00:10:12,620
+حساب زيتا وإبسلون نصل لمرحلة بيبدأ دور ال liver
+
+117
+00:10:12,620 --> 00:10:19,420
+وكل اللي بيتصنع هو Alpha Gamma و بتبدأ ال Beta ثم
+
+118
+00:10:19,420 --> 00:10:23,800
+تليها ال Delta في التصنيع ففي ال liver من ستة
+
+119
+00:10:23,800 --> 00:10:27,740
+لتلاتين weeks ال main hemoglobin اللي بيتصنع هو
+
+120
+00:10:27,740 --> 00:10:33,240
+Alpha Gamma Twoولمّا تبدأ تصنع الـ Delta جزء منها
+
+121
+00:10:33,240 --> 00:10:39,400
+بيصنع لنا Alpha Delta 2 Hemoglobin A2 وبعد ذلك
+
+122
+00:10:39,400 --> 00:10:47,700
+ببعد الولادة البومارو هو الأساس في تصنيع ال RBC's
+
+123
+00:10:47,700 --> 00:10:52,500
+أو ال Hemopoiesis ودم ال Hemoglobin الأساسي في هذا
+
+124
+00:10:52,500 --> 00:10:58,640
+الحالة بيكون Hemoglobin A وهو Alpha Beta 2 وهذا
+
+125
+00:10:58,640 --> 00:11:04,260
+عبارة عنالـ switching of hemoglobin في المراحل
+
+126
+00:11:04,260 --> 00:11:11,660
+المختلفة تبعت اللي هو ال embryonic life و بعدها في
+
+127
+00:11:11,660 --> 00:11:16,220
+ال neonatal life ففي ال embryonic ده هو جوهر واحد
+
+128
+00:11:16,220 --> 00:11:20,800
+نقول Portland جوهر two y, z, و epsilon اي شي
+
+129
+00:11:20,800 --> 00:11:27,200
+بتكونوا embryo في ال fetus بعد هيك بتبدأ الجالفة
+
+130
+00:11:27,200 --> 00:11:33,070
+والجامعةوبدو يزيدوا على حساب ياش ال zeta والإبسلون
+
+131
+00:11:33,070 --> 00:11:36,430
+وفي هذه الحالة بيكون ال liver هو الأساس و ال major
+
+132
+00:11:36,430 --> 00:11:40,470
+hemoglobin هو ال hemoglobin F وإذا دخلت تالتة أدي
+
+133
+00:11:40,470 --> 00:11:48,970
+على الخط بيصير hemoglobin E2 على اللي بتصنع بعد
+
+134
+00:11:48,970 --> 00:11:54,510
+هيك ال bomber هو الأساس في كل تصنيع ال hemoglobin
+
+135
+00:11:54,510 --> 00:11:58,380
+وزي ما انتوا شايفين ال alpha و ال beta هي الأساسو
+
+136
+00:11:58,380 --> 00:12:06,220
+هناك قليل من Gamma طبعا
+
+137
+00:12:06,220 --> 00:12:09,520
+هذه الـ switching phenomena اللي بتصير ده هي أول
+
+138
+00:12:09,520 --> 00:12:14,360
+شي بيكون في زيتا تبدأ تزيد Alpha على حساب زيتا و
+
+139
+00:12:14,360 --> 00:12:20,800
+أنا ببدأ اللي هو يزيد Gamma على حساب إبسلون فتنزل
+
+140
+00:12:20,800 --> 00:12:28,110
+الإبسلون و بتزيد Gamma بعد الحل للولادة بيصيريعني
+
+141
+00:12:28,110 --> 00:12:39,250
+after birth بيصير ال beta و ال alpha هي الأساس اه
+
+142
+00:12:39,250 --> 00:12:44,730
+sorry ال beta بتزيد على حساب gamma ده هي فكله
+
+143
+00:12:44,730 --> 00:12:49,470
+بيصير alpha و betaأدل الهيموجلوبين في النهاية
+
+144
+00:12:49,470 --> 00:12:53,490
+بيكون عبارة عن مرمى الأدل الهيموجلوبين بيكون عبارة
+
+145
+00:12:53,490 --> 00:12:59,970
+عن الهيموجلوب A Alpha 2 Beta 2 96-98% وA2 Alpha
+
+146
+00:12:59,970 --> 00:13:04,750
+Delta الكل 2 و نص واحد و نص لتلاتة و اتنين و ده
+
+147
+00:13:04,750 --> 00:13:08,010
+مهم جدا لتحديد أنواع مغينة من القديمة بالذات
+
+148
+00:13:08,010 --> 00:13:13,350
+ثلاثينية فهو الهيموجلوب F وهو Alpha 2 Gamma 2 وهو
+
+149
+00:13:13,350 --> 00:13:16,250
+أقل من واحد في المية point five to point eight
+
+150
+00:13:16,250 --> 00:13:21,340
+percentageوهذا الـ Global Synthesis قلنا على two
+
+151
+00:13:21,340 --> 00:13:25,620
+gene cluster واحد اللي هو كرمزوم رقم 11 والتاني 16
+
+152
+00:13:25,620 --> 00:13:29,620
+الكرمزوم رقم 11 موجود عليه ال beta-like gene
+
+153
+00:13:29,620 --> 00:13:33,320
+cluster وزي ما تشايفين فينا Beta gene Delta gene
+
+154
+00:13:33,320 --> 00:13:37,780
+Magama gene و Epsilon يعني أربع أنواع من إيه الشيء
+
+155
+00:13:37,780 --> 00:13:42,680
+الجيناتالجامعة هن في عندنا نوعين بيختلفوا فقط في
+
+156
+00:13:42,680 --> 00:13:47,220
+أمينو أسد واحد وهو الـG والـA الألانين والعيسين في
+
+157
+00:13:47,220 --> 00:13:50,780
+رقم
+
+158
+00:13:50,780 --> 00:13:57,660
+145 أمينو أسد بينما
+
+159
+00:13:57,660 --> 00:14:03,800
+الـAlpha Globin gene cluster موجودة على كرمزوم رقم
+
+160
+00:14:03,800 --> 00:14:08,320
+16 وزي ما تشوفون في عندنا زيتا نوعين they are
+
+161
+00:14:08,320 --> 00:14:11,530
+similarوAlpha نوعين يعني two types of globin
+
+162
+00:14:11,530 --> 00:14:17,130
+بيتصنعوا اتنين نفس الكمية ونفس النوع من Alpha
+
+163
+00:14:17,130 --> 00:14:24,510
+وبنوع ال hemoglobin المختلفة وما يدخل في تركيبها
+
+164
+00:14:24,510 --> 00:14:31,850
+Structure ال structure بيتكوّن
+
+165
+00:14:31,850 --> 00:14:34,510
+من أربع أشكال primary و secondary و tertiary و
+
+166
+00:14:34,510 --> 00:14:37,790
+quaternary ال primary بيعتمد على
+
+167
+00:14:43,950 --> 00:14:48,010
+الله أبو صلى الله عليه و سلم و محمد الـ primary
+
+168
+00:14:48,010 --> 00:14:49,650
+structure of the global reflected in the amino
+
+169
+00:14:49,650 --> 00:14:54,330
+acid sequence of the various chains امينو أسل
+
+170
+00:14:54,330 --> 00:15:00,010
+سيكوانس يعني فقط بنعد واحد ورا التاني ماشي بينما
+
+171
+00:15:00,010 --> 00:15:06,030
+ال secondary يبقى تكوّن من 9 non helical joined
+
+172
+00:15:06,030 --> 00:15:12,550
+with 8 helicalالـ Helical بيعطوهم
+
+173
+00:15:12,550 --> 00:15:19,030
+أرقام A,B,C بينما الـ Non-helical هو عبارة عن يعني
+
+174
+00:15:19,030 --> 00:15:24,770
+وصلة ما بين two helical فبتاخد الرقامين القبل
+
+175
+00:15:24,770 --> 00:15:27,990
+واللي بعد يعني ال helical اللي جابلها و ال helical
+
+176
+00:15:27,990 --> 00:15:31,630
+اللي بعدها فبتصير لنا مثلًا على سبيل المثال الـ
+
+177
+00:15:31,630 --> 00:15:37,490
+Non-helicalالأولى هي A B وهي ما بين الهليكس A و
+
+178
+00:15:37,490 --> 00:15:41,690
+الهليكس B وهذا هو مصمم الهليكس الهليكس الانهليكس
+
+179
+00:15:41,690 --> 00:15:45,170
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+180
+00:15:45,170 --> 00:15:46,970
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+181
+00:15:46,970 --> 00:15:47,350
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+182
+00:15:47,350 --> 00:15:48,570
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+183
+00:15:48,570 --> 00:15:54,850
+الانهليكس
+
+184
+00:15:54,850 --> 00:16:00,130
+الانهليكس الانهليكس الانهليكس الانهليكس الانهليكس
+
+185
+00:16:00,130 --> 00:16:04,500
+الانهليكس الانهليكس الانهليكس الانههي مجلبة تأخذ
+
+186
+00:16:04,500 --> 00:16:14,160
+شكل الـ Sphere وبيتكلم عن Intramolecular Bonds هي
+
+187
+00:16:14,160 --> 00:16:18,780
+المسؤولة عن الـ helical partوهي مسؤولة عن ال
+
+188
+00:16:18,780 --> 00:16:25,500
+agility of the molecule و بتؤدي إلى تصميم انها
+
+189
+00:16:25,500 --> 00:16:29,520
+نهرك و جالوا في ال tertiary في تلت مناطق مهمة جدا
+
+190
+00:16:29,520 --> 00:16:33,520
+تلت characteristic feature sorry مهمة جدا اما واحد
+
+191
+00:16:33,520 --> 00:16:42,580
+ان ال polar or chart side ال chain بتكون برا وهذه
+
+192
+00:16:42,580 --> 00:16:50,480
+بتؤكد على انهعلى ان الموليكيول هيدروفوبك وبالتالي
+
+193
+00:16:50,480 --> 00:16:57,940
+صليبل بينما ال non polar بتكون روابط داخلية وهذا
+
+194
+00:16:57,940 --> 00:17:02,900
+يعني على ان الموليكيول من جوا هو هيدروفوبك مابده
+
+195
+00:17:02,900 --> 00:17:06,980
+ميه تخش جوا وبالتالي بدهش يتأكسد من جوا
+
+196
+00:17:11,030 --> 00:17:15,510
+الـ Heme Bucket is created بيصير فيه Opened Top
+
+197
+00:17:15,510 --> 00:17:21,610
+Left للموليكيول بنفتح من هنا و بيصير فيه إيش الـ
+
+198
+00:17:21,610 --> 00:17:24,890
+Heme Bucket due بالهيم موجودة في الـ Tertiary
+
+199
+00:17:24,890 --> 00:17:31,590
+Structure و طبعا الـ Due بالهيم موجدت عشان شغلتين
+
+200
+00:17:31,590 --> 00:17:38,510
+شغل أولانية عشان تحمل ال Oxygen في جواتها نمرا
+
+201
+00:17:38,510 --> 00:17:43,540
+اتنين عشان تتضمنتحت حماية الـ Ferrous-Ion اللي
+
+202
+00:17:43,540 --> 00:17:48,420
+موجودة في داخل الـGlobin.نبغى تلاتة الـAmino Acid
+
+203
+00:17:48,420 --> 00:17:56,180
+اللي موجود سواء كان Inter-Subunit Bonding مسئول عن
+
+204
+00:17:56,180 --> 00:18:00,020
+الـQuaternary Structure اللي بدأت تكون بعد ذلك
+
+205
+00:18:00,020 --> 00:18:05,320
+وهذا الـQuaternary Structure والـQuaternary
+
+206
+00:18:05,320 --> 00:18:11,750
+Structure of Hemoglobin له أربع Subunitsمرتبة في
+
+207
+00:18:11,750 --> 00:18:17,550
+الـ hemoglobin A بشكل القاتل المراوحة بتتكون روابط
+
+208
+00:18:17,550 --> 00:18:22,810
+Alpha 1 Beta 1 أو Alpha 2 Beta 2 وهذه روابط قوية
+
+209
+00:18:22,810 --> 00:18:28,470
+مسؤولة عن stability of the molecule بتشكل حوالي
+
+210
+00:18:28,470 --> 00:18:32,910
+تشترك في تكوينها حوالي 30 amino acidsبينما الروابط
+
+211
+00:18:32,910 --> 00:18:37,370
+التانية Alpha-1 Beta-2 Alpha-2 Beta-1 وهذه تقوم
+
+212
+00:18:37,370 --> 00:18:41,290
+بإعادة الـ Solubility روابط الأمينواسد التي تشترك
+
+213
+00:18:41,290 --> 00:18:44,710
+فيها حوالي عشرين أمينواسد وأخر واحدة Alpha-1
+
+214
+00:18:44,710 --> 00:18:49,230
+بAlpha-2 Beta-1 Beta-2 وهذه أضعفهم، أضعف الروابط
+
+215
+00:18:49,230 --> 00:18:52,670
+لأنه مسئول عن تعمل ال Oxygenation وDeoxygenation
+
+216
+00:18:52,670 --> 00:18:59,050
+وبالتالي مقموض منها أنها تفتح وتتسكر Function of
+
+217
+00:18:59,050 --> 00:19:04,640
+Hemoglobinبتعرف انه Oxygen delivery to the tissue
+
+218
+00:19:04,640 --> 00:19:10,000
+وطبيعة التفاعل ما بين ال Hemoglobin و ال Oxygen
+
+219
+00:19:10,000 --> 00:19:14,300
+بيعتمد على ال Oxygen نفسي Oxygenation و ليس
+
+220
+00:19:14,300 --> 00:19:18,140
+Oxidation Oxygenation يعني حمل الأكسجين و ليس
+
+221
+00:19:18,140 --> 00:19:24,230
+أكسدة ال Hemoglobin يعني مش تفاعل كيميائينمرة
+
+222
+00:19:24,230 --> 00:19:28,810
+اتنين كل لن هيموجلوبين برتبط باربع ذرات من
+
+223
+00:19:28,810 --> 00:19:35,530
+الأكسجين نمرة تلاتة عملية ال Oxygenation لا تتعدى
+
+224
+00:19:35,530 --> 00:19:41,050
+ال point O one second يعني بس يخش الهيموجلوبين على
+
+225
+00:19:41,050 --> 00:19:45,690
+اللان يصير فيه Oxygenation للهيموجلوبين عملية ال
+
+226
+00:19:45,690 --> 00:19:48,190
+Oxygenation بتتم من خلال تباعد
+
+227
+00:19:50,490 --> 00:19:53,890
+حركة الموليكيوسوري وجدوا انه يوم ما يصير فيه
+
+228
+00:19:53,890 --> 00:20:00,170
+Oxygenation بيصير فيه Beta Chain Closing يعني ال
+
+229
+00:20:00,170 --> 00:20:04,670
+Beta Chain بتقرب على بعض و يوم ما تقرب على بعض ال
+
+230
+00:20:04,670 --> 00:20:10,130
+heme بوكت مفتحه فبخش ال Oxygen في داخل ال heme يوم
+
+231
+00:20:10,130 --> 00:20:16,330
+ما تبعد ال Beta Chain عن بعض ماشي أرض أرض يعني
+
+232
+00:20:16,870 --> 00:20:21,610
+بيصير فيه ضغط على الـ hem pocket فبتطلع ال oxygen
+
+233
+00:20:21,610 --> 00:20:26,050
+اللي في جلبها عشان هيك بيصير في oxygen unloading
+
+234
+00:20:26,050 --> 00:20:30,650
+وفي نفس الوقت في مركب اسمه 23dbg
+
+235
+00:20:30,650 --> 00:20:36,030
+-diphosphoglycerate هو اللي بيدخل في داخل ال
+
+236
+00:20:36,030 --> 00:20:41,430
+hemoglobin موليكيوم وبالتالي بيعتبر ال 23dbg منافس
+
+237
+00:20:41,430 --> 00:20:49,700
+لأكسجين في دخوله
+
+238
+00:20:49,700 --> 00:20:55,000
+إلى الـ Hemoglobin أو تحميل الـ Hemoglobin فهذه
+
+239
+00:20:55,000 --> 00:20:59,380
+الصورة كما تشاهدون هي الـ Hembucket فاتحة فالـ
+
+240
+00:20:59,380 --> 00:21:06,380
+Oxygen داخلها و هذا معناته ان الـ Beta Chain جربت
+
+241
+00:21:06,380 --> 00:21:10,020
+على بعض سكرت
+
+242
+00:21:10,020 --> 00:21:11,740
+يعني ففتحت الـ Hembucket
+
+243
+00:21:18,430 --> 00:21:25,110
+الهيمبوك تباعد عن بعضها تباعد عن بعضها تباعد عن
+
+244
+00:21:25,110 --> 00:21:32,010
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+245
+00:21:32,010 --> 00:21:32,010
+تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها تباعد
+
+246
+00:21:32,010 --> 00:21:32,010
+عن بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن
+
+247
+00:21:32,010 --> 00:21:33,970
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+248
+00:21:33,970 --> 00:21:33,970
+تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها تباعد
+
+249
+00:21:33,970 --> 00:21:33,970
+عن بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن
+
+250
+00:21:33,970 --> 00:21:36,110
+بعضها تباعد عن بعضها تباعد عن بعضها تباعد عن بعضها
+
+251
+00:21:36,110 --> 00:21:40,940
+تباعد عن بعضها تبمشي طلعت فضت الجوايه الجيوب ال
+
+252
+00:21:40,940 --> 00:21:45,800
+oxygen اللي في جلبها ومين دخل دخل 23dbg في النص
+
+253
+00:21:45,800 --> 00:21:53,280
+صار الهمoglobin دي oxygenated معروف
+
+254
+00:21:53,280 --> 00:21:58,780
+ان ال normal hemoglobin في كل gram منه بيرتبط ب 1
+
+255
+00:21:58,780 --> 00:22:03,940
+.34 ميلي من ال oxygen يعني واحد عنده hemoglobin 14
+
+256
+00:22:03,940 --> 00:22:09,950
+gram تقريبا بيحملعشرين مل من الأكسجين عشرين مل من
+
+257
+00:22:09,950 --> 00:22:13,590
+ال .. بتحمل بعشرين مل من الأكسجين تقريبا تسعت عشر
+
+258
+00:22:13,590 --> 00:22:18,270
+نص لأنه ما بيصيرش complete اللي هو loading
+
+259
+00:22:18,270 --> 00:22:23,670
+للأكسجين ال degree of saturation تعتبد على ال
+
+260
+00:22:23,670 --> 00:22:30,070
+oxygen tension و كلنا بنعرف أن بغض الأكسجين في ال
+
+261
+00:22:30,070 --> 00:22:34,450
+lung حوالي نيت ملي متر ذئبق بينما في ال tissue
+
+262
+00:22:35,150 --> 00:22:38,750
+حوالي خمسة و تلاتين ملي متر زي ابقى فالفرق في
+
+263
+00:22:38,750 --> 00:22:42,990
+الضغط بحد ذاته كمان هو عامل من الهوامل انه يصير
+
+264
+00:22:42,990 --> 00:22:48,930
+عملية تعباية او تفضاية لل Hemoglobin العملية هذه
+
+265
+00:22:48,930 --> 00:22:54,410
+مثلوها رياضيا ال curve سموه oxygen dissociation
+
+266
+00:22:54,410 --> 00:22:59,730
+curve of Hemoglobin و قالوا ان من صفاته
+
+267
+00:23:02,260 --> 00:23:05,880
+إنه بيعكس ال properties of hemoglobin itself
+
+268
+00:23:05,880 --> 00:23:15,160
+وقالوا إنه بيتأثر بعوامل عدة هذي العوامل لاتؤثر
+
+269
+00:23:15,160 --> 00:23:19,980
+على شكل ال curve وإنما تؤثر على موقع ال curve
+
+270
+00:23:19,980 --> 00:23:27,460
+فبتحرك ال curve إما يمينا وإما يسارا طبعا هي و كما
+
+271
+00:23:27,460 --> 00:23:30,180
+تشوفون العلاقة ما بين ال lung و ال tissue في ال
+
+272
+00:23:30,180 --> 00:23:35,160
+lung ده هوبتحمل الهيموجلوبين بالأكسجين و لما بروح
+
+273
+00:23:35,160 --> 00:23:38,560
+اتشه بصير فيه release للهيموجلوبين للأكسجين من
+
+274
+00:23:38,560 --> 00:23:42,080
+الهيموجلوبين و مش بس release بتحمل بساني اكسي
+
+275
+00:23:42,080 --> 00:23:44,640
+الكربون برجع تاني على ال lung و هناك بصير فيه
+
+276
+00:23:44,640 --> 00:23:50,780
+release ل ال CO2 to the lung وهي ال normal
+
+277
+00:23:50,780 --> 00:23:53,800
+hemoglobin oxygen dissociation curve اللي هو
+
+278
+00:23:53,800 --> 00:23:57,720
+الأزرق هذا هو اللي في النص وقولنا في بعض العوامل
+
+279
+00:23:57,720 --> 00:24:02,380
+اللي بتؤثر على موقع ال curveفإما يأتي على اليمين
+
+280
+00:24:02,380 --> 00:24:07,460
+أو يذهب إلى الشمال لكن شكل الكيرب يبقى كما هو فإما
+
+281
+00:24:07,460 --> 00:24:14,020
+يصبح الهيموجلبي right shifted أو left shifted بس
+
+282
+00:24:14,020 --> 00:24:20,220
+يجب أن ناخد في هذا الاعتبار أنه عند 50% تقريبا أو
+
+283
+00:24:20,220 --> 00:24:26,060
+40% الهيموجلبي
+
+284
+00:24:26,060 --> 00:24:27,500
+تشوفوا لحظه
+
+285
+00:24:30,380 --> 00:24:34,380
+الضغط اكسوجين 40% اللي هو في ال tissue بيكون ال
+
+286
+00:24:34,380 --> 00:24:42,040
+hemoglobin محمل فقط ب 75% من ال oxygen و طب البذل
+
+287
+00:24:42,040 --> 00:24:45,460
+راح في ال tissue صار releasing في ال tissue ففي كل
+
+288
+00:24:45,460 --> 00:24:52,260
+مرة ال hemoglobin لما دخل ال tissue ينزل حوال 12%
+
+289
+00:24:52,260 --> 00:24:58,120
+من اللي هو ال oxygen
+
+290
+00:25:04,190 --> 00:25:06,810
+ما هي العاملة اللى بتعمل اللى بتغير على شكل اللى
+
+291
+00:25:06,810 --> 00:25:09,730
+هو موقع ال Hemoglobin Oxygen Dissociation Care
+
+292
+00:25:09,730 --> 00:25:13,790
+اللى عامل Hemoglobin Variant نوعه انا هسوي مثال
+
+293
+00:25:13,790 --> 00:25:20,500
+Hemoglobin S هناماشى و ال decrease of oxygen
+
+294
+00:25:20,500 --> 00:25:27,340
+affinity و ال pH لما بتقل ال acidity و يوم يكون ال
+
+295
+00:25:27,340 --> 00:25:30,200
+2 3 D بيجي عالى بيكون ال CO2 عالى ال antimicrobial
+
+296
+00:25:30,200 --> 00:25:38,480
+عالية بيصير في shift ال curve to the rightماشي وده
+
+297
+00:25:38,480 --> 00:25:41,500
+وده فبيعني ان هذا الظروف اللي جعلنا نحكي عنها هي
+
+298
+00:25:41,500 --> 00:25:44,840
+عبارة عن ظروف بتصير فيهاش في ال tissue ففي ال
+
+299
+00:25:44,840 --> 00:25:48,980
+tissue بتصير في unloading يعني بتقل ال affinity of
+
+300
+00:25:48,980 --> 00:25:52,320
+Hemoglobin to bind with Oxygen فبتصير في releasing
+
+301
+00:25:52,320 --> 00:25:58,620
+unloading يعني ماشي وعلى العكس من ذلك يوم يكون في
+
+302
+00:25:58,620 --> 00:26:03,560
+Hemoglobin variant تاني زي Hemoglobin F انه له
+
+303
+00:26:03,560 --> 00:26:07,590
+high affinity to Oxygenبتزيد ال affinity يوم يكون
+
+304
+00:26:07,590 --> 00:26:15,650
+زيادة في ال pH ماشي DBG قليل PCO2 قليل or
+
+305
+00:26:15,650 --> 00:26:20,270
+temperature is low بيصير في high affinity of two
+
+306
+00:26:20,270 --> 00:26:26,430
+oxygen وبالتالي بيصير shifting to the left وهي ال
+
+307
+00:26:26,430 --> 00:26:30,710
+hemoglobin oxygen dissociation curve وهي العوامل
+
+308
+00:26:30,710 --> 00:26:32,530
+اللي بتودي هيك و بتودي هيك
+
+309
+00:26:37,200 --> 00:26:44,040
+الهيموغلبن عادى ان يتعامل
+
+310
+00:26:44,040 --> 00:26:45,240
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+311
+00:26:45,240 --> 00:26:46,820
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+312
+00:26:46,820 --> 00:26:47,040
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+313
+00:26:47,040 --> 00:26:47,240
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+314
+00:26:47,240 --> 00:26:47,240
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+315
+00:26:47,240 --> 00:26:48,340
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بشكل عادى
+
+316
+00:26:48,340 --> 00:26:51,780
+بشكل عادى بشكل عادى بشكل عادى بشكل عادى بش
+
+317
+00:26:55,870 --> 00:27:02,330
+طبعا هذا الكلام بيحصل يوم يكون الضغط الأكسجين هو
+
+318
+00:27:02,330 --> 00:27:08,910
+27.1% و 27.5% في الفتاة وبالتالي
+
+319
+00:27:08,910 --> 00:27:11,990
+وإذا أزداد مرتبط الأكسجين الـ dissociation curve
+
+320
+00:27:11,990 --> 00:27:16,750
+is shifted leftward and value is reduced وإذا
+
+321
+00:27:16,750 --> 00:27:17,730
+أزداد مرتبط الأكسجين الـ Conversely decreased
+
+322
+00:27:17,730 --> 00:27:21,290
+oxygen affinity ال curve بيصير على ال right الكلام
+
+323
+00:27:21,290 --> 00:27:22,090
+هذا حاجة نحتوي
+
+324
+00:27:25,060 --> 00:27:27,960
+هذه العوامل اللي بتؤثر على ال oxygen dissociation
+
+325
+00:27:27,960 --> 00:27:35,380
+curve وهذه اللي بتعمله left shifting وهذه بتعمل
+
+326
+00:27:35,380 --> 00:27:41,120
+right shifting وهذه التانتين ونبدأ بأول هذه
+
+327
+00:27:41,120 --> 00:27:44,780
+العوامل وهي ال power effect يا بناته يا شباب
+
+328
+00:27:44,780 --> 00:27:50,660
+افهموني ال power effect يعني دور ال pH في علاقته
+
+329
+00:27:50,660 --> 00:27:55,720
+بال oxygen affinityببساطة الهيموجلوب ال oxygen
+
+330
+00:27:55,720 --> 00:28:01,920
+affinity is reduced كل مكان ال acidity اكتر طب
+
+331
+00:28:01,920 --> 00:28:06,720
+وكتيرش بيكون في acidity لما يكون الهيموجلوب يفتشه
+
+332
+00:28:06,720 --> 00:28:10,500
+يعني فتشه بزيد ال acidity طبعا مش بيصير في
+
+333
+00:28:10,500 --> 00:28:19,160
+metabolism ومحصلة ال metabolic pathway هي تكونالـ
+
+334
+00:28:19,160 --> 00:28:23,460
+Lactate أو الـ Lactic أسد الـ Formation وCO2
+
+335
+00:28:23,460 --> 00:28:26,300
+والتاني يكونوا Hydrochloric أدلة هو Carbonic أسد
+
+336
+00:28:26,300 --> 00:28:30,320
+والتاني عبارة عن أسدك Medium فبالتالي في ال tissue
+
+337
+00:28:30,320 --> 00:28:36,920
+ال oxygen affinity is decreased مين أثر عليها؟ ال
+
+338
+00:28:36,920 --> 00:28:44,070
+pH شو كان في دور ال pH؟ أسدك طبعا هذا الكلامبيكون
+
+339
+00:28:44,070 --> 00:28:52,410
+عكسه موجود في الـ Lung بيكون
+
+340
+00:28:52,410 --> 00:28:55,710
+عكسه موجود في الـ Lung بيكون عكسه موجود في الـ
+
+341
+00:28:55,710 --> 00:28:57,750
+Lung بيكون عكسه موجود في الـ Lung بيكون عكسه موجود
+
+342
+00:28:57,750 --> 00:28:59,350
+في الـ Lung بيكون عكسه موجود في الـ Lung بيكون
+
+343
+00:28:59,350 --> 00:29:00,270
+عكسه موجود في الـ Lung بيكون عكسه موجود في الـ
+
+344
+00:29:00,270 --> 00:29:00,270
+Lung بيكون عكسه موجود في الـ Lung بيكون عكسه موجود
+
+345
+00:29:00,270 --> 00:29:00,270
+في الـ Lung بيكون عكسه موجود في الـ Lung بيكون
+
+346
+00:29:00,270 --> 00:29:00,270
+عكسه موجود في الـ Lung بيكون عكسه موجود في الـ
+
+347
+00:29:00,270 --> 00:29:00,370
+Lung بيكون عكسه موجود في الـ Lung بيكون عكسه موجود
+
+348
+00:29:00,370 --> 00:29:06,940
+في الـ Lدور الـ 2,3-DBG، وما هو الـ 2,3-DBG؟ قالوا
+
+349
+00:29:06,940 --> 00:29:09,880
+إن هذا عبارة عن مُركّب أحد نواتج الـ glycolytic
+
+350
+00:29:09,880 --> 00:29:16,040
+pathway اللي موجودة في الـ RBCs وين بتصنع في أي
+
+351
+00:29:16,040 --> 00:29:20,540
+جزء غيره، بتصنع في جزء الرابع بوصوله برينشان، وش
+
+352
+00:29:20,540 --> 00:29:26,520
+بصير؟ بتصنع الـ 2,3-DBG في الـ glycolytic pathway،
+
+353
+00:29:26,520 --> 00:29:30,180
+طيب، إيش اللي بصير؟ احنا بنحكي glycolytic pathway
+
+354
+00:29:30,690 --> 00:29:35,110
+يعني عمال ما بيحكي على طاقة، إنتاج طاقة وكأحد
+
+355
+00:29:35,110 --> 00:29:38,790
+المخلفات اللي بتنتج الـ 2,3-DPG اللي يوم ما ..
+
+356
+00:29:38,790 --> 00:29:44,090
+وكدهش محتاج الطاقة، فتشهر فتشهر و تزيد اللي هو الـ
+
+357
+00:29:44,090 --> 00:29:48,250
+glycolytic activity فمزيد الـ 2,3-DPG ويوم ما يزيد
+
+358
+00:29:48,250 --> 00:29:52,830
+الـ 2,3-DPG قلنا هو عبارة عن منافس قوي لمين للـ
+
+359
+00:29:52,830 --> 00:29:56,850
+Hemoglobin في ارتباطه بالأكسجين فبيطلع الأكسجين،
+
+360
+00:29:56,850 --> 00:30:01,090
+بيعمل unloading للأكسجين و بيخش محل إلهاجفي نص الـ
+
+361
+00:30:01,090 --> 00:30:07,170
+Hemoglobin وبالتالي يوم يزيد الـ 2,3-DBG بيقل الـ
+
+362
+00:30:07,170 --> 00:30:12,910
+Oxygen loading بيصير Unloading بينجوسين بتقل ال
+
+363
+00:30:12,910 --> 00:30:19,270
+Affinity to Oxygen وبزيد ال Release وهي الـ 2,3
+
+364
+00:30:19,270 --> 00:30:25,350
+-DBG هي هذا اللي في النص Normal يوم زاد صار يوم قل
+
+365
+00:30:25,350 --> 00:30:27,030
+صار
+
+366
+00:30:29,700 --> 00:30:40,520
+صار سفر فوق في ال tissue اللي هو ال oxygen بي
+
+367
+00:30:40,520 --> 00:30:44,880
+بي جي بي بي جي بي بي بي بي بي بي بي بي بي بي بي بي
+
+368
+00:30:44,880 --> 00:30:46,460
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+369
+00:30:46,460 --> 00:30:47,300
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+370
+00:30:47,300 --> 00:30:47,300
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+371
+00:30:47,300 --> 00:30:47,300
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+372
+00:30:47,300 --> 00:30:47,420
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+373
+00:30:47,420 --> 00:30:53,520
+بي
+
+374
+00:30:53,520 --> 00:30:55,840
+ب
+
+375
+00:30:57,630 --> 00:31:01,510
+لما صار تمانية يعني زاد صار فيه قلة في ال oxygen
+
+376
+00:31:01,510 --> 00:31:08,170
+affinity وبالتالي shift to the right لما ال ox
+
+377
+00:31:08,170 --> 00:31:15,910
+hemoglobin stride of 23 dbg قل
+
+378
+00:31:15,910 --> 00:31:20,590
+فصار زيادة في ال oxygen affinity وبالتالي اتحمل ده
+
+379
+00:31:20,590 --> 00:31:24,110
+و shift to the left ماشي مرة تانية اللي في النص
+
+380
+00:31:24,110 --> 00:31:29,300
+normalHemoglobin L23dBG هو خمسة ملي مول per liter
+
+381
+00:31:29,300 --> 00:31:35,460
+لما زاد وصل ل تمانية ايه الكيروف ايه الكيروف صار
+
+382
+00:31:35,460 --> 00:31:39,800
+على اليمين لما قلت L23dBG صار الكيروف على الشمال
+
+383
+00:31:39,800 --> 00:31:44,040
+لاننا نعرف ان الكيروف لما يسير على اليمين يعني ال
+
+384
+00:31:44,040 --> 00:31:49,720
+affinity بتقل و ال release بزيد و لما بسير نروح
+
+385
+00:31:49,720 --> 00:31:56,730
+على الشمالالـ Affinity بتزيد والـ Release بقل وهى
+
+386
+00:31:56,730 --> 00:31:59,870
+زى ما قلتلكوا وين بتصنع هذى ال glycolytic pathway
+
+387
+00:31:59,870 --> 00:32:03,010
+كله ال glycolytic pathway طبعا ليش؟ طبعا العربيسيز
+
+388
+00:32:03,010 --> 00:32:06,930
+وان شاء الله هنتطرق اليه ب .. اللى هي مولتكاليميا
+
+389
+00:32:06,930 --> 00:32:10,510
+قدام زى ما انتوا شايفين بيتكون من تلت أجزاء أساسية
+
+390
+00:32:10,510 --> 00:32:15,590
+الأولاني هذا هو الرئيسي ال glucose بتحول لمين؟ ل
+
+391
+00:32:15,590 --> 00:32:20,840
+Lactate او Lactic Acidوبتصنع في هذه العملية بيتكون
+
+392
+00:32:20,840 --> 00:32:26,760
+تلاتة ATP ثم في two شنط هي واحدة و هي واحدة الشنط
+
+393
+00:32:26,760 --> 00:32:30,040
+الألمانية بيسموها Pentose Phosphate شنط وكل اللي
+
+394
+00:32:30,040 --> 00:32:34,900
+بتصنع فيها الناد BH اللي مطلوب for reduction of
+
+395
+00:32:34,900 --> 00:32:43,320
+oxygen وشنط التانية ذي رابابورت لبريان شنط ذي ان
+
+396
+00:32:43,320 --> 00:32:47,860
+بيتكون فيها two 3 DBG ماشي واحدة قولنا منافس قوي
+
+397
+00:32:47,860 --> 00:32:51,320
+لميه؟للهيموجلوبين للأكسجين في ارتباطه
+
+398
+00:32:51,320 --> 00:32:55,720
+بالهيموجلوبين دي
+
+399
+00:32:55,720 --> 00:33:00,520
+اللي هو كيف يتكوّل الأيام
+
+400
+00:33:00,520 --> 00:33:04,400
+يكون ال oxygen is unloaded with hemoglobin by
+
+401
+00:33:04,400 --> 00:33:09,440
+hemoglobin 23DPG بيكون داخل ال hemoglobin وبيسمو
+
+402
+00:33:09,440 --> 00:33:12,520
+ال hemoglobin molecule في هذه الحالة tense form
+
+403
+00:33:12,520 --> 00:33:18,140
+tense form ليش؟ لإن هو فاض أو فضةاللي مجلد محمل
+
+404
+00:33:18,140 --> 00:33:24,440
+الـ 2,3-dBG المحصلة الـ Affinity to Oxygen is
+
+405
+00:33:24,440 --> 00:33:29,580
+lowered ولمّا يكون العكس الـ 2,3-dBG is expelled
+
+406
+00:33:29,580 --> 00:33:36,840
+out زاد الـ Oxygen Affinity الـ PO2 Pressure of
+
+407
+00:33:36,840 --> 00:33:40,900
+Oxygen وهذا بزيد في الـ Lung الـ 2,3-dBG بيصل الـ
+
+408
+00:33:40,900 --> 00:33:45,880
+Expelling outوالهيموجلبل بتحمل بالأكسجين وبيسموه
+
+409
+00:33:45,880 --> 00:33:49,640
+ال relaxed form وفي هذا الحال ال affinity to
+
+410
+00:33:49,640 --> 00:33:54,440
+oxygen is high وهذه العملية ما بتحول الهيموجلبل من
+
+411
+00:33:54,440 --> 00:33:58,080
+tense to relax تينس توريلاكس تينس توريلاكس تينس
+
+412
+00:33:58,080 --> 00:33:59,700
+توريلاكس تينس توريلاكس تينس توريلاكس تينس توريلاكس
+
+413
+00:33:59,700 --> 00:34:02,220
+تينس توريلاكس تينس توريلاكس تينس توريلاكس تينس
+
+414
+00:34:02,220 --> 00:34:02,220
+توريلاكس تينس توريلاكس تينس توريلاكس تينس توريلاكس
+
+415
+00:34:02,220 --> 00:34:02,220
+تينس توريلاكس تينس توريلاكس تينس توريلاكس تينس
+
+416
+00:34:02,220 --> 00:34:05,360
+توريلاكس تينس
+
+417
+00:34:05,360 --> 00:34:09,120
+توريلاكس
+
+418
+00:34:09,120 --> 00:34:14,060
+تينس توريلاكability of hemoglobin to bind to 2,3
+
+419
+00:34:14,060 --> 00:34:17,940
+-DBG وهذا الكلام بيحصل في الـ fetal hemoglobin الـ
+
+420
+00:34:17,940 --> 00:34:22,520
+fetal hemoglobin ما عنده القدرة على الارتباط بالـ
+
+421
+00:34:22,520 --> 00:34:26,900
+2,3-DBG فبيضل محمل بقاش بالأكسجين وبالتالي ال
+
+422
+00:34:26,900 --> 00:34:33,620
+affinity to oxygen is high 2
+
+423
+00:34:33,620 --> 00:34:36,640
+,3-DBG concentration يتأثر بعدة عوامل منها على
+
+424
+00:34:36,640 --> 00:34:41,670
+سبيل المثال الhypoxia فجاله في حالات الhypoxiaبصير
+
+425
+00:34:41,670 --> 00:34:50,810
+فيه زيادة في تركيز الـ 2,3 dBG والـ Oxygen
+
+426
+00:34:50,810 --> 00:34:59,130
+Affinity بتقل كمان ال delivery of oxygen
+
+427
+00:34:59,130 --> 00:35:01,410
+to tissue is facilitating
+
+428
+00:35:04,240 --> 00:35:07,880
+على سبيل المثال في بعض حالات الـ Hypoxia زي الـ
+
+429
+00:35:07,880 --> 00:35:10,600
+High Attitude و الـ Anoxia و الـ Pulmonary or
+
+430
+00:35:10,600 --> 00:35:14,500
+Cardiac Disease or Blood Loss or Anemia ماشي هذا
+
+431
+00:35:14,500 --> 00:35:22,860
+الكلام بيصير to 3D بيجي بيصير له زيادة
+
+432
+00:35:22,860 --> 00:35:26,640
+و يوم ما يزيد بقعد في ال Oxygen فبالتالي ال
+
+433
+00:35:26,640 --> 00:35:29,440
+Affinity to Oxygen بيقعد في ال Hemoglobin فبالتالي
+
+434
+00:35:29,440 --> 00:35:32,840
+ال Affinity to Oxygen بتقل و Release of Oxygen
+
+435
+00:35:32,840 --> 00:35:37,330
+كمان بتقلوهذا نوع من ال adaptation نوع من ال
+
+436
+00:35:37,330 --> 00:35:42,090
+adaptation الزيادة في ال two three دي بيجيب تلعب
+
+437
+00:35:42,090 --> 00:35:45,230
+دور كبير في ال adaptation to exercise also يوم
+
+438
+00:35:45,230 --> 00:35:50,010
+الواحد يجري ويفقد كميات كبيرة من أياش من اللي هو
+
+439
+00:35:50,010 --> 00:35:56,330
+الطاقةالحالة المطلوبة أن نعمل adaptation كيف يحدث
+
+440
+00:35:56,330 --> 00:35:59,050
+ال adaptation؟ نريد أن نقلل كمية ال oxygen اللي
+
+441
+00:35:59,050 --> 00:36:04,330
+نفقدها فبتدخل تركيز الدوس الريدي بيتحمل في
+
+442
+00:36:04,330 --> 00:36:07,730
+الهيموجلوبين بيقل الهيموجلوبين affinity بيتقل
+
+443
+00:36:07,730 --> 00:36:13,730
+الهيموجلوبين release عام
+
+444
+00:36:13,730 --> 00:36:16,330
+الآخر بيؤثر على الهيموجلوبين كاربون ديكسايد كاربون
+
+445
+00:36:16,330 --> 00:36:23,390
+ديكسايد طبعابفتبط الشرطبات مباشر بال Hemoglobin
+
+446
+00:36:23,390 --> 00:36:26,630
+وإنما بيصير ال diffusion في داخل ال RBCs و
+
+447
+00:36:26,630 --> 00:36:29,990
+diffusion في داخل ال Hemoglobin لكنه بيصير ال
+
+448
+00:36:29,990 --> 00:36:34,610
+diffusion بالقاتل قبل ما يصير ال Hemoglobin لو CO2
+
+449
+00:36:34,610 --> 00:36:39,510
+بيتعرض ده إيش ل two reaction أول reaction CO2 مع
+
+450
+00:36:39,510 --> 00:36:44,910
+ميا بيكوّن carbonic acid وال carbonic acid يتحول
+
+451
+00:36:44,910 --> 00:36:47,250
+إلى بيكربونيت وهيدروجين
+
+452
+00:36:51,020 --> 00:36:55,320
+ماشي أي ال carbon dioxide diffuse freely into the
+
+453
+00:36:55,320 --> 00:37:02,100
+RBCs و هذا بيشكل اللي هو أيش انه ال reaction
+
+454
+00:37:02,100 --> 00:37:07,660
+الأولاني ان ال steel H plus liberated in reaction
+
+455
+00:37:07,660 --> 00:37:12,650
+two is accepted by deoxygenated hemoglobinوهذه
+
+456
+00:37:12,650 --> 00:37:16,790
+طبعا اللي بيأثر فيها هو عبارة عن Pohar Effect الـ
+
+457
+00:37:16,790 --> 00:37:23,090
+Bicarbonate جثتها جثة بس كل ما هناك انه هي diffuse
+
+458
+00:37:23,090 --> 00:37:29,130
+freely across the red cell membrane وجزء منها
+
+459
+00:37:29,130 --> 00:37:33,890
+بيصير exchange هو ال chloride اللي موجود في
+
+460
+00:37:33,890 --> 00:37:39,870
+البلازمة بيسموها chloride shift ال bicarbonate بعد
+
+461
+00:37:39,870 --> 00:37:43,640
+ذلك بتنعمل in plasma to the lungوهناك بيصلها
+
+462
+00:37:43,640 --> 00:37:49,480
+ventilation as PCO2 is low وانا بيقدي الى ال
+
+463
+00:37:49,480 --> 00:37:56,020
+exertion او excretion of CO2 لان 70% من ال carbon
+
+464
+00:37:56,020 --> 00:38:02,240
+dioxide بيتم التخلص منه بهذه الطريقة و 30% اللي
+
+465
+00:38:02,240 --> 00:38:06,760
+دايرين 5% موجودين هنا simple solution و 25%
+
+466
+00:38:06,760 --> 00:38:09,900
+برتبطوا بال Hemoglobin و بيكونوا Carb Amino
+
+467
+00:38:09,900 --> 00:38:15,790
+Hemoglobinمت هموبلبنينيا احنا مطلوب منها ان
+
+468
+00:38:15,790 --> 00:38:21,670
+الهموبلبن يظل دائما بحالة in reduced form و
+
+469
+00:38:21,670 --> 00:38:25,650
+reduced form اللي احنا نبسط فيه ان الفرس ان ال
+
+470
+00:38:25,650 --> 00:38:30,830
+iron atom يظل in its فرس form يعني reduced form
+
+471
+00:38:30,830 --> 00:38:36,430
+لما يتأكسد الحديد يبطل عنده القدرة على ايش على
+
+472
+00:38:36,430 --> 00:38:42,810
+الارتباط بالهموبلبن او حمل الهموبلبنليه؟ عشان يكلا
+
+473
+00:38:42,810 --> 00:38:45,450
+في داخل القرعات الدم الحمراء في عدة ميكانيزم
+
+474
+00:38:45,450 --> 00:38:50,850
+مسئولة عن إيش؟ عن الحفاف بشكل دايم على ال reduced
+
+475
+00:38:50,850 --> 00:38:55,790
+form of hemoglobinوقت ايش بيحصل في مت-همoglobin؟
+
+476
+00:38:55,790 --> 00:38:58,930
+قالوا فيه تلات حالات الحال الأولانية إذا كان ال
+
+477
+00:38:58,930 --> 00:39:02,330
+RBCs is exposed to certain oxidant و لا كله مابخش
+
+478
+00:39:02,330 --> 00:39:05,910
+اكسيدان المطلوب من ال RBCs انه يخلصنا من ال
+
+479
+00:39:05,910 --> 00:39:10,870
+oxidant أول بول نمرة اتنين إذا كان ال intrinsic
+
+480
+00:39:10,870 --> 00:39:13,450
+protective mechanism اللي هو الميكانيزم الداخلي
+
+481
+00:39:13,450 --> 00:39:18,190
+هذا خرب اللي بيحافظ على ال reduced form نمرة تلاتة
+
+482
+00:39:18,190 --> 00:39:21,370
+إذا كان فيه genetic abnormality؟ قالوا في بعض
+
+483
+00:39:21,370 --> 00:39:22,570
+النوع من ال hemoglobin
+
+484
+00:39:25,190 --> 00:39:31,370
+بـaffected اللي هو global stability أو اللي هو الـ
+
+485
+00:39:31,370 --> 00:39:34,690
+hemoglobin طبعا هذه أدولة صورتين الصورة هذه عبارة
+
+486
+00:39:34,690 --> 00:39:38,310
+عن ميكانيزم تبع الـ Intrapascular Hemolysis وزي ما
+
+487
+00:39:38,310 --> 00:39:40,990
+أنتوا شايفين أنا مش راح أخد فيها هتاخدها في ال
+
+488
+00:39:40,990 --> 00:39:45,770
+clinical chemistry بالتفصيل في ال Intrapascular
+
+489
+00:39:45,770 --> 00:39:49,090
+Hemolysis تسر قوة الدم الحوراء و بزيد ال بالروبين
+
+490
+00:39:49,450 --> 00:39:52,190
+بقل الـ Heptoglobin الـ Heptoglobin هو عبارة عن
+
+491
+00:39:52,190 --> 00:39:58,390
+Hemoglobin Carrier Compound فلما بيزيد الـ
+
+492
+00:39:58,390 --> 00:40:00,950
+Hemoglobin اللي طالع من داخل الخضرية مرتبط بالـ
+
+493
+00:40:00,950 --> 00:40:03,510
+Heptoglobin فبقل الـ Hemoglobin الـ Heptoglobin
+
+494
+00:40:03,510 --> 00:40:09,290
+تركيزا ماشي و بضل فدي عندنا Free Hemoglobin موجود
+
+495
+00:40:09,290 --> 00:40:12,790
+برضه و ايضا الـ Extravascular زي ما انتوا شايفين
+
+496
+00:40:12,790 --> 00:40:16,370
+هاي ال Hemoglobin بتكسر شره Hemoglobin اللي ناخد
+
+497
+00:40:16,370 --> 00:40:22,110
+من ال Iron بضل Globinهو بيظل اللي هو ال .. ال ..
+
+498
+00:40:22,110 --> 00:40:22,950
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+499
+00:40:22,950 --> 00:40:23,310
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+500
+00:40:23,310 --> 00:40:23,370
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+501
+00:40:23,370 --> 00:40:24,130
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+502
+00:40:24,130 --> 00:40:25,910
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+503
+00:40:25,910 --> 00:40:26,230
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+504
+00:40:26,230 --> 00:40:31,410
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+505
+00:40:31,410 --> 00:40:32,270
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+506
+00:40:32,270 --> 00:40:32,350
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+507
+00:40:32,350 --> 00:40:36,330
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+508
+00:40:36,330 --> 00:40:36,330
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+509
+00:40:36,330 --> 00:40:36,330
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+510
+00:40:36,330 --> 00:40:43,350
+ال .. ال .. ال .. ال .. ال
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ef0640cb337b5b3e8ac7fd2055479cb4f0eca197
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_postprocess.srt
@@ -0,0 +1,512 @@
+1
+00:00:07,340 --> 00:00:15,060
+إكمالا للمحاضرة وصلنا إلى cycle of hemopoiesis
+
+2
+00:00:15,060 --> 00:00:22,040
+أماكن تصنيع غلايا الدم المختلفة و كما تشاهدون هناك
+
+3
+00:00:22,040 --> 00:00:23,400
+عدة أماكن
+
+4
+00:00:37,680 --> 00:00:48,880
+fatty tissue بيسموه yellow marrow بتزيد ال .. او
+
+5
+00:00:48,880 --> 00:00:51,880
+بيتحول ال yellow marrow الى red marrow عند الحاجة
+
+6
+00:00:51,880 --> 00:00:57,140
+وبالتالي بيعتبر ال yellow marrow هو عبارة عن مخزن
+
+7
+00:00:57,140 --> 00:01:01,920
+للدم
+
+8
+00:01:06,570 --> 00:01:15,490
+زى ما انتوا شايفين فى الصورة فى أول شهرين بيكون
+
+9
+00:01:15,490 --> 00:01:25,990
+اليوكساك هو الأساس فى عملية التصنيع ثم بعد تقريبا
+
+10
+00:01:25,990 --> 00:01:34,510
+الأسبوع السادس يبدأ تهاجر خلية من الاستمثال على ال
+
+11
+00:01:34,510 --> 00:01:34,730
+liver
+
+12
+00:01:41,520 --> 00:01:46,020
+الخلايا في ال liver شوية شوية بيقلل اليوكساك ثم
+
+13
+00:01:46,020 --> 00:01:52,600
+بيحل محله ال liver بشكل أساسي في هذه فترة فترة ال
+
+14
+00:01:52,600 --> 00:01:58,140
+liver زي ما تلاحظين ال spleen بيساهم في عملية
+
+15
+00:01:58,140 --> 00:02:06,700
+التصنيع لكن بشكل قليل في الشهر الرابع تقريبا بيبدأ
+
+16
+00:02:06,700 --> 00:02:15,500
+ال bone marrowكمصنع أساسي أو مصنع لتصنيع الخلايا
+
+17
+00:02:15,500 --> 00:02:22,060
+وبيبدأ يزيد ال bone marrow ويتناقص دور ال liver
+
+18
+00:02:22,060 --> 00:02:25,120
+لغاية
+
+19
+00:02:25,120 --> 00:02:26,000
+ما نصل إلى
+
+20
+00:02:38,180 --> 00:02:43,300
+من اليهش من اللي بيأثر وبالتالي و زي ما انتوا
+
+21
+00:02:43,300 --> 00:02:49,980
+شايفين ال bone marrow بيتكون من عدة أذعم أساسية زي
+
+22
+00:02:49,980 --> 00:02:54,320
+ال vertebrae و ال pelvis و ال sternum و اللي هي
+
+23
+00:02:54,320 --> 00:03:03,260
+عضمة القص ثم اللبس و الفيمر و التيبة اللي هو أذعم
+
+24
+00:03:03,260 --> 00:03:03,900
+القدم
+
+25
+00:03:06,910 --> 00:03:12,230
+وهذا تفصيل لل active hemopoietic marrow لانه بيكون
+
+26
+00:03:12,230 --> 00:03:17,330
+موجود في الأطفال in the axial skeleton زي ال
+
+27
+00:03:17,330 --> 00:03:21,170
+cranium و ال ribs و ال sternum و ال vertebrae و ال
+
+28
+00:03:21,170 --> 00:03:25,370
+pelvis بينما
+
+29
+00:03:25,370 --> 00:03:33,390
+شوى شوى في ال adult بيبدأ يتركز في العظم العريضة
+
+30
+00:03:44,500 --> 00:03:57,040
+Cranium والبلفش بشكل أساسي طبعا
+
+31
+00:03:57,040 --> 00:04:03,360
+يجي نشرح بالظبط هذه العملية كيف تتم اذا العملية
+
+32
+00:04:03,360 --> 00:04:10,260
+تتم أولا في الأول مواقع أو التي يتم فيها تصنيع
+
+33
+00:04:10,260 --> 00:04:18,740
+الدم هي ال Yorkshireوبيبدأ تصنيع اليوكساك في خلال
+
+34
+00:04:18,740 --> 00:04:25,740
+سبعين إلى تلت أسابيع of after fertilization و
+
+35
+00:04:25,740 --> 00:04:32,820
+اليوكساك بيتكون من تلت تلاتة layers اللي هي
+
+36
+00:04:32,820 --> 00:04:37,860
+الectoderm و ال mesoderm و الendoderm بتنشأ
+
+37
+00:04:37,860 --> 00:04:46,890
+الاستمثل للأمواللي بيسموها Hemangioplast في منطقة
+
+38
+00:04:46,890 --> 00:04:51,810
+الميزو ديرم من الميزو ديرم تطلع خلية ال
+
+39
+00:04:51,810 --> 00:04:55,210
+Hemangioplast اللي هي عبارة عن إيش الخلية
+
+40
+00:05:01,490 --> 00:05:06,990
+أساسيتين to stem cell واحدة مسئولة عن تصنيع blood
+
+41
+00:05:06,990 --> 00:05:12,470
+vessels والتانية مسئولة عن تصنيع blood cells طبيعي
+
+42
+00:05:12,470 --> 00:05:16,010
+ال blood cells بدؤون قنوات للبلد
+
+43
+00:05:18,380 --> 00:05:22,180
+مش راح تمشي و التاني بيتصنع ال blood vessels و
+
+44
+00:05:22,180 --> 00:05:28,120
+بيتصنع الخلايا مع بعض two stem cell واحدة مسئولة
+
+45
+00:05:28,120 --> 00:05:33,580
+عن تصنيع ال blood vessels و التانية مسئولة عن
+
+46
+00:05:33,580 --> 00:05:41,620
+تصنيع ال blood cells الكلام
+
+47
+00:05:41,620 --> 00:05:46,620
+هذا طبعا بيصير في ال embryo و بيبدأ
+
+48
+00:05:55,790 --> 00:06:01,910
+وأول الخلايا اللتي تصنع هي الارتروسايتز طبيعي جدا
+
+49
+00:06:01,910 --> 00:06:10,810
+لأنها هفر Oxygen Carrying وبعد شهرين تقريبا يوم ما
+
+50
+00:06:10,810 --> 00:06:16,010
+يصير الفيتس عمره شهرين تبدأ تتصنع ال Granulocyte
+
+51
+00:06:16,010 --> 00:06:20,910
+وميجا كارلوسايتزفي بداية الشهر الرابع بتبدأ ال
+
+52
+00:06:20,910 --> 00:06:25,570
+lymphocyte بالتصنيع يبقى أول الخلايا تصنيعا هي ال
+
+53
+00:06:25,570 --> 00:06:29,790
+erythrocyte ثم ال granulocyte و ال megakaryocyte
+
+54
+00:06:29,790 --> 00:06:37,150
+ثم ال lymphocyte آخر خلايا تصنع هي ال monocyte
+
+55
+00:06:37,150 --> 00:06:46,430
+تصنع في الشهر الخامس من الشهر التالد للشهر السابع
+
+56
+00:06:46,430 --> 00:06:46,990
+ال
+
+57
+00:06:52,950 --> 00:07:00,030
+Hemopoietic organ يعني بيخلص دور اليوكساج و بنتهي
+
+58
+00:07:00,030 --> 00:07:05,810
+الشهر التاني من الشهر التالت لشهر السابع بيبدأ
+
+59
+00:07:05,810 --> 00:07:13,730
+مصنع جديد بالتصنيع وهو liver بشكل أساسي ثم ال
+
+60
+00:07:13,730 --> 00:07:22,300
+spleen بشكلطبعا في هذه المرحلة الـ Erythropoietic
+
+61
+00:07:22,300 --> 00:07:30,480
+activity still هي الأساس ويكون معاها minimal
+
+62
+00:07:30,480 --> 00:07:35,760
+granulopoiesis وقلنا granulopoiesis يعني تصنيف لل
+
+63
+00:07:35,760 --> 00:07:44,850
+granulocytes فبسموها granulopoiesis بعد ذلك قلنافي
+
+64
+00:07:44,850 --> 00:07:49,970
+بداية الشهر الرابع بيبدأ ال bone marrow بالتصنيع
+
+65
+00:07:49,970 --> 00:07:57,610
+في وجود ال liver و بيبدأ يزيد شوي شوي على حساب ال
+
+66
+00:07:57,610 --> 00:08:01,670
+liver يعني بينقص ال liver و هو بيزيد و في ال bone
+
+67
+00:08:01,670 --> 00:08:02,690
+marrow بيبدأ
+
+68
+00:08:06,570 --> 00:08:09,110
+والـ Granulocytes اللي هي عبارة عن نيوتروفيل
+
+69
+00:08:09,110 --> 00:08:13,810
+الجينوفيل وبيزوفيل و ال lymphocytes و ال monocytes
+
+70
+00:08:13,810 --> 00:08:20,450
+اللي بتديناها ال macro phage و ال placulate تاني
+
+71
+00:08:20,450 --> 00:08:26,530
+في مصطلح تصنيع هذا اللي بيتم في ال boron maroon
+
+72
+00:08:26,530 --> 00:08:32,170
+بيسموه Intramedullary Hemopoiesis لكن في مصطلح
+
+73
+00:08:32,170 --> 00:08:38,660
+تاني بيسموه Extramedullary Hemopoiesisو هذا يوم
+
+74
+00:08:38,660 --> 00:08:48,400
+نحتاجه في الأزمات بيبدأ يتحول ال yellow marrow إلى
+
+75
+00:08:48,400 --> 00:08:57,200
+red marrow أو بيبدأ الاستعانة بال liver or spleen
+
+76
+00:08:57,200 --> 00:08:59,420
+كمصانع أولية
+
+77
+00:09:05,350 --> 00:09:09,530
+في الأزمات يوم ما يكون الإنترنت الإنسان محتاج
+
+78
+00:09:09,530 --> 00:09:15,550
+تصنيع خلايا أكتر من اللزوم طبعا هذه المواقع اللي
+
+79
+00:09:15,550 --> 00:09:20,730
+دخلت على الخط بتضاعف من إنتاج الخلايا قالوا أن
+
+80
+00:09:20,730 --> 00:09:29,450
+وجودها بيداعف من إنتاج الخلايا بست أضعف وبالتالي
+
+81
+00:09:31,080 --> 00:09:35,680
+هذه المواقع بيسموها extra-medallary ومش ننساه انه
+
+82
+00:09:35,680 --> 00:09:41,660
+في مصطلح تاني هو الـ intra-medallary وهو تصنيع
+
+83
+00:09:41,660 --> 00:09:45,540
+الخلايا في البرمال هي المراحل اللتي تمار فيها
+
+84
+00:09:45,540 --> 00:09:49,240
+limopoietic stem cell development تطور الخلايا
+
+85
+00:09:49,240 --> 00:09:54,160
+قلنا بس يكون عندنا في stem cell pool اللي عندها
+
+86
+00:09:54,160 --> 00:09:59,900
+القدرة على تجديد نفسها بستمرار Renewalلكنها أيضًا
+
+87
+00:09:59,900 --> 00:10:05,340
+عندها قدرة to differentiate بسلة differentiation و
+
+88
+00:10:05,340 --> 00:10:09,120
+بتديني حاجة بسمها lineage selection يعني بتبدأي
+
+89
+00:10:09,120 --> 00:10:16,100
+تختار خط صيرها بدها تديني اما RBCs او IPCs او
+
+90
+00:10:16,100 --> 00:10:22,100
+granulocytes يعني او الinfocytes whatever هي بتبدأ
+
+91
+00:10:22,100 --> 00:10:27,140
+تختار خط صيرها بسمها lineage من line selection
+
+92
+00:10:27,140 --> 00:10:34,110
+تختارثم بعد ما تحدد خط سيرة بتبدأ بالنضوج بتمر
+
+93
+00:10:34,110 --> 00:10:38,370
+الخلية في عدة مراحل لغاية ما تصل إلى ال mature
+
+94
+00:10:38,370 --> 00:10:42,890
+form و طبعا ال mature form يعني functioning form
+
+95
+00:10:42,890 --> 00:10:48,580
+بتعيش ال life span تبعتها ثم بتموت by apoptosisثم
+
+96
+00:10:48,580 --> 00:10:52,100
+بتموت by Apoptosis وبالتالي الخلية تمر في عدة
+
+97
+00:10:52,100 --> 00:10:57,120
+مراحل أول مرحلة هي differentiation ثم lineage
+
+98
+00:10:57,120 --> 00:11:02,800
+specific or selection ثم maturation ثم function
+
+99
+00:11:02,800 --> 00:11:11,340
+and death وده صورة بتؤدي أو بتبين ليس ال hierarchy
+
+100
+00:11:11,340 --> 00:11:15,060
+اللي قلناه اللي بيصير في ال hemopoiesis
+
+101
+00:11:17,730 --> 00:11:21,430
+المختلفة اللى بتمر فيها الخلية لو جينا شرحناها
+
+102
+00:11:21,430 --> 00:11:26,970
+هنقول ان فى خلية أم دهية فى خلية أم سمنها
+
+103
+00:11:26,970 --> 00:11:31,870
+pluripotent stem cell انقسمت وعتطنى نوعين من
+
+104
+00:11:31,870 --> 00:11:37,070
+الخلايا myeloid stem cell و lymphoid stem cell ال
+
+105
+00:11:37,070 --> 00:11:43,390
+myeloid قلناها هى أم كل الخلايا
+
+106
+00:11:46,180 --> 00:11:49,740
+و ال limphoid stem cell بتديني ال lymphocyte
+
+107
+00:11:49,740 --> 00:11:54,520
+بأنواع تبقى عندي pluripotent stem cell ده هي ده
+
+108
+00:11:54,520 --> 00:11:58,140
+اتنى myeloid stem cell و limphoid stem cell ال
+
+109
+00:11:58,140 --> 00:12:03,020
+myeloid هي بتديني كل أنواع الخلايا هي RBCs,
+
+110
+00:12:03,060 --> 00:12:05,580
+platelets, monocytes, neutrophils, eosinophils,
+
+111
+00:12:05,660 --> 00:12:08,720
+bezophils، كل ال myeloid series
+
+112
+00:12:14,110 --> 00:12:18,650
+اللي إلها stem cell خاصة فيها بتديني أنواع ال
+
+113
+00:12:18,650 --> 00:12:27,610
+lymphocytes وده يعني ال B cell وD cell بشكل مختلف
+
+114
+00:12:27,610 --> 00:12:34,670
+طبعا هذه الخلايا زي ما قلنا بتمر في قدة مراحل أول
+
+115
+00:12:34,670 --> 00:12:41,470
+مرحلة اللي ال stem cell ثم ال progenitor cell اللي
+
+116
+00:12:41,470 --> 00:12:46,590
+morphologically unrecognizableثم ال recognizable
+
+117
+00:12:46,590 --> 00:12:50,750
+form طبعا هي ال morphologically recognizable form
+
+118
+00:12:50,750 --> 00:12:55,030
+مانقدرش احنا نميز ثم بعد ذلك بيجي ال
+
+119
+00:12:55,030 --> 00:12:58,470
+morphologically recognizable هنا بدنا نسمي الخلايا
+
+120
+00:12:58,470 --> 00:13:03,330
+و يمر الخلية في عدة مراحل لغاية ما تصل ل mature
+
+121
+00:13:03,330 --> 00:13:13,910
+form ماشي هذه صورة تانية للخلايا بالمراحل المختلفة
+
+122
+00:13:23,160 --> 00:13:28,920
+mature very immature ثم تحت تصل الخلايا الى
+
+123
+00:13:28,920 --> 00:13:33,100
+recognizable form يعني سهل التعرف عليها سهل
+
+124
+00:13:33,100 --> 00:13:41,860
+تسميتها نتيجة اسمها وتتميز الخلايا بطريقة واضحة
+
+125
+00:13:41,860 --> 00:13:45,660
+وبالتالي كل خلية بتمر في عدة مراحل لغاية ما تصل في
+
+126
+00:13:45,660 --> 00:13:53,170
+النهاية ل mature form هذا كل ما يتعلق بالstem cell
+
+127
+00:13:53,170 --> 00:13:59,770
+اللى هو قولنا العامل الاول اللى يعتمد او تعتمد على
+
+128
+00:13:59,770 --> 00:14:01,810
+ال hemapoiesis process
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..ee67c7519a657e6304be7652c35c07dac546521a
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/2ayKGuSl8QY_raw.json
@@ -0,0 +1 @@
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ما انتوا شايفين ال bone marrow بيتكون من عدة أذعم أساسية زي ال vertebrae و ال pelvis و ال sternum و اللي هي عضمة القص ثم اللبس و الفيمر و التيبة اللي هو أذعم القدم", "tokens": [27842, 45595, 3224, 8592, 9154, 13672, 1829, 4724, 1829, 10721, 49115, 46599, 6027, 2655, 6027, 1829, 4032, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 2423, 9026, 47739, 4724, 36081, 4117, 11536, 9154, 6225, 41891, 5551, 8848, 3615, 2304, 5551, 3794, 32277, 10632, 30767, 1829, 2423, 16167, 6198, 68, 4032, 2423, 34617, 4032, 2423, 38312, 449, 4032, 13672, 1829, 39896, 6225, 11242, 46007, 25062, 9381, 38637, 2304, 13672, 3555, 3794, 4032, 27188, 32640, 2288, 4032, 16712, 1829, 49401, 13672, 1829, 31439, 5551, 8848, 3615, 2304, 25062, 40448], "avg_logprob": -0.29166665607028536, "compression_ratio": 1.706806282722513, "no_speech_prob": 1.1801719665527344e-05, "words": [{"start": 158.18, "end": 158.56, "word": "من", "probability": 0.459716796875}, {"start": 158.56, "end": 159.22, "word": " 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"end": 406.43, "word": " السابع", "probability": 0.9798177083333334}, {"start": 406.43, "end": 406.99, "word": " ال", "probability": 0.86767578125}], "temperature": 1.0}, {"id": 15, "seek": 43507, "start": 412.95, "end": 435.07, "text": "Hemopoietic organ يعني بيخلص دور اليوكساج و بنتهي الشهر التاني من الشهر التالت لشهر السابع بيبدأ مصنع جديد بالتصنيع وهو liver بشكل أساسي ثم ال spleen بشكل", "tokens": [39, 443, 404, 78, 1684, 299, 1798, 37495, 22653, 4724, 1829, 9778, 1211, 9381, 11778, 13063, 45595, 2407, 4117, 3794, 26108, 4032, 4724, 29399, 3224, 1829, 25124, 3224, 2288, 16712, 7649, 1829, 9154, 25124, 3224, 2288, 16712, 6027, 2655, 5296, 8592, 3224, 2288, 21136, 16758, 3615, 4724, 1829, 44510, 10721, 3714, 9381, 1863, 3615, 10874, 16254, 3215, 20666, 2655, 9381, 22653, 3615, 37037, 2407, 15019, 4724, 8592, 28820, 5551, 3794, 32277, 1829, 38637, 2304, 2423, 637, 28238, 4724, 8592, 28820], "avg_logprob": -0.2193286978168252, "compression_ratio": 1.5454545454545454, "no_speech_prob": 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"word": " الشهر", "probability": 0.9864908854166666}, {"start": 422.31, "end": 422.85, "word": " التالت", "probability": 0.9820963541666666}, {"start": 422.85, "end": 423.67, "word": " لشهر", "probability": 0.88134765625}, {"start": 423.67, "end": 424.31, "word": " السابع", "probability": 0.96826171875}, {"start": 424.31, "end": 425.81, "word": " بيبدأ", "probability": 0.94384765625}, {"start": 425.81, "end": 427.29, "word": " مصنع", "probability": 0.9901123046875}, {"start": 427.29, "end": 428.23, "word": " جديد", "probability": 0.9920247395833334}, {"start": 428.23, "end": 429.73, "word": " بالتصنيع", "probability": 0.91923828125}, {"start": 429.73, "end": 430.01, "word": " وهو", "probability": 0.695068359375}, {"start": 430.01, "end": 430.47, "word": " liver", "probability": 0.4833984375}, {"start": 430.47, "end": 431.15, "word": " بشكل", "probability": 0.9342447916666666}, {"start": 431.15, "end": 431.97, "word": " أساسي", "probability": 0.954345703125}, {"start": 431.97, "end": 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447.36, "end": 448.74, "word": " ويكون", "probability": 0.76513671875}, {"start": 448.74, "end": 449.4, "word": " معاها", "probability": 0.90478515625}, {"start": 449.4, "end": 450.48, "word": " minimal", "probability": 0.8330078125}, {"start": 450.48, "end": 451.96, "word": " granulopoiesis", "probability": 0.740234375}, {"start": 451.96, "end": 452.36, "word": " وقلنا", "probability": 0.69744873046875}, {"start": 452.36, "end": 453.76, "word": " granulopoiesis", "probability": 0.9181315104166666}, {"start": 453.76, "end": 454.02, "word": " يعني", "probability": 0.94287109375}, {"start": 454.02, "end": 455.2, "word": " تصنيف", "probability": 0.9095458984375}, {"start": 455.2, "end": 455.76, "word": " لل", "probability": 0.7705078125}, {"start": 455.76, "end": 457.02, "word": " granulocytes", "probability": 0.67169189453125}, {"start": 457.02, "end": 457.72, "word": " فبسموها", "probability": 0.7927734375}, {"start": 457.72, "end": 460.04, "word": " granulopoiesis", "probability": 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0.985595703125}, {"start": 471.19, "end": 471.35, "word": " ال", "probability": 0.7666015625}, {"start": 471.35, "end": 471.63, "word": " liver", "probability": 0.96728515625}, {"start": 471.63, "end": 473.75, "word": " و", "probability": 0.80712890625}, {"start": 473.75, "end": 474.27, "word": " بيبدأ", "probability": 0.80181884765625}, {"start": 474.27, "end": 474.81, "word": " يزيد", "probability": 0.9876302083333334}, {"start": 474.81, "end": 475.37, "word": " شوي", "probability": 0.772705078125}, {"start": 475.37, "end": 475.73, "word": " شوي", "probability": 0.8583984375}, {"start": 475.73, "end": 476.21, "word": " على", "probability": 0.87744140625}, {"start": 476.21, "end": 476.89, "word": " حساب", "probability": 0.869140625}, {"start": 476.89, "end": 477.61, "word": " ال", "probability": 0.68701171875}, {"start": 477.61, "end": 477.91, "word": " liver", "probability": 0.9912109375}, {"start": 477.91, "end": 478.25, "word": " يعني", "probability": 0.811767578125}, {"start": 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51557, "start": 486.57, "end": 515.57, "text": "والـ Granulocytes اللي هي عبارة عن نيوتروفيل الجينوفيل وبيزوفيل و ال lymphocytes و ال monocytes اللي بتديناها ال macro phage و ال placulate تاني في مصطلح تصنيع هذا اللي بيتم في ال boron maroon بيسموه Intramedullary Hemopoiesis لكن في مصطلح تاني بيسموه Extramedullary Hemopoiesis", "tokens": [2407, 6027, 39184, 23554, 425, 905, 43673, 13672, 1829, 39896, 6225, 3555, 9640, 3660, 18871, 8717, 1829, 35473, 32887, 5172, 26895, 25724, 9957, 38688, 26895, 4032, 21292, 11622, 38688, 26895, 4032, 2423, 31070, 905, 43673, 4032, 2423, 1108, 905, 43673, 13672, 1829, 39894, 16254, 8315, 11296, 2423, 18887, 903, 609, 4032, 2423, 20831, 5256, 6055, 7649, 1829, 8978, 3714, 9381, 9566, 1211, 5016, 6055, 9381, 22653, 3615, 23758, 13672, 1829, 4724, 36081, 2304, 8978, 2423, 14828, 266, 1849, 4106, 4724, 1829, 38251, 2407, 3224, 5681, 2356, 292, 858, 822, 18568, 404, 78, 530, 271, 44381, 8978, 3714, 9381, 9566, 1211, 5016, 6055, 7649, 1829, 4724, 1829, 38251, 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46599, 6027, 2655, 6027, 1829, 28242, 16490, 1211, 10632, 39894, 29973, 8978, 6225, 41891, 3714, 23557, 5016, 1211, 5296, 17082, 995, 10632, 19446, 6055, 36520, 8978, 28239, 11296, 10632, 5296, 14442, 1254, 23758, 28242, 19446, 7251, 2655, 30241, 4587, 20666], "avg_logprob": -0.17751289151378513, "compression_ratio": 1.7175925925925926, "no_speech_prob": 0.00014472007751464844, "words": [{"start": 803.16, "end": 803.74, "word": "mature", "probability": 0.53472900390625}, {"start": 803.74, "end": 804.18, "word": " very", "probability": 0.1497802734375}, {"start": 804.18, "end": 804.84, "word": " immature", "probability": 0.904296875}, {"start": 804.84, "end": 805.9, "word": " ثم", "probability": 0.9228515625}, {"start": 805.9, "end": 806.56, "word": " تحت", "probability": 0.94677734375}, {"start": 806.56, "end": 807.68, "word": " تصل", "probability": 0.59808349609375}, {"start": 807.68, "end": 808.4, "word": " الخلايا", "probability": 0.9436848958333334}, {"start": 808.4, "end": 808.92, 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"probability": 0.985595703125}, {"start": 825.54, "end": 825.66, "word": " في", "probability": 0.703125}, {"start": 825.66, "end": 826.04, "word": " النهاية", "probability": 0.8380533854166666}, {"start": 826.04, "end": 826.18, "word": " ل", "probability": 0.66259765625}, {"start": 826.18, "end": 826.58, "word": " mature", "probability": 0.2188720703125}, {"start": 826.58, "end": 827.76, "word": " form", "probability": 0.7978515625}, {"start": 827.76, "end": 829.4, "word": " هذا", "probability": 0.66357421875}, {"start": 829.4, "end": 829.68, "word": " كل", "probability": 0.98876953125}, {"start": 829.68, "end": 829.84, "word": " ما", "probability": 0.96630859375}, {"start": 829.84, "end": 830.46, "word": " يتعلق", "probability": 0.9893798828125}, {"start": 830.46, "end": 830.78, "word": " بال", "probability": 0.94384765625}], "temperature": 1.0}, {"id": 30, "seek": 84181, "start": 832.31, "end": 841.81, "text": "stem cell اللى هو قولنا العامل الاول اللى يعتمد او تعتمد على ال hemapoiesis process", "tokens": [1099, 2815, 13672, 7578, 31439, 12174, 12610, 8315, 18863, 10943, 1211, 42963, 12610, 13672, 7578, 7251, 34268, 2304, 3215, 1975, 2407, 6055, 34268, 2304, 3215, 15844, 2423, 8636, 569, 78, 530, 271, 1399], "avg_logprob": -0.3306525691467173, "compression_ratio": 1.2989690721649485, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 832.31, "end": 832.77, "word": "stem", "probability": 0.382568359375}, {"start": 832.77, "end": 833.17, "word": " cell", "probability": 0.88232421875}, {"start": 833.17, "end": 833.95, "word": " اللى", "probability": 0.60888671875}, {"start": 833.95, "end": 834.35, "word": " هو", "probability": 0.5888671875}, {"start": 834.35, "end": 835.25, "word": " قولنا", "probability": 0.7019856770833334}, {"start": 835.25, "end": 835.79, "word": " العامل", "probability": 0.9781901041666666}, {"start": 835.79, "end": 836.59, "word": " الاول", "probability": 0.7275390625}, {"start": 836.59, "end": 837.75, "word": " اللى", "probability": 0.960693359375}, {"start": 837.75, "end": 838.55, "word": " يعتمد", "probability": 0.87841796875}, {"start": 838.55, "end": 839.01, "word": " او", "probability": 0.830078125}, {"start": 839.01, "end": 839.59, "word": " تعتمد", "probability": 0.9599609375}, {"start": 839.59, "end": 839.77, "word": " على", "probability": 0.4208984375}, {"start": 839.77, "end": 839.97, "word": " ال", "probability": 0.8046875}, {"start": 839.97, "end": 841.15, "word": " hemapoiesis", "probability": 0.52216796875}, {"start": 841.15, "end": 841.81, "word": " process", "probability": 0.7421875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 845.6475625, "duration_after_vad": 725.7187500000014}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..75774414cc81650d94904fb65dc1a28ee09f98e5
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_postprocess.srt
@@ -0,0 +1,2772 @@
+1
+00:00:01,940 --> 00:00:04,480
+بسم الله الرحمن الرحيم الصلاة والسلام علي سيد
+
+2
+00:00:04,480 --> 00:00:10,260
+الخلق أجمعين سيدنا محمد الصادق الأمين وبعد نلتقي
+
+3
+00:00:10,260 --> 00:00:18,980
+اليوم في محاضرة جديدة بعنوان chronic leukemia و by
+
+4
+00:00:18,980 --> 00:00:24,580
+definition chronic leukemiaهي عبارة عن بلوكيميا
+
+5
+00:00:24,580 --> 00:00:28,800
+بتحدث فيها mutation على مستوى ال stem cell in a
+
+6
+00:00:28,800 --> 00:00:32,560
+single stem cell mutation حصلت in a single stem
+
+7
+00:00:32,560 --> 00:00:37,060
+cell و قد تكون هذه ال stem cell فى البضمرة او ال
+
+8
+00:00:37,060 --> 00:00:45,680
+tissue انما ما يتبع ذلك ان هذه الخدية تنقسم قسمات
+
+9
+00:00:45,680 --> 00:00:52,140
+عديدة Campyloferin و بتكون clonal populationاللي
+
+10
+00:00:52,140 --> 00:00:58,240
+لما بيكون ماس كبيرة بيعمل
+
+11
+00:00:58,240 --> 00:01:03,920
+المرض مافي أنواع ال chronic leukemia النوعين حسب
+
+12
+00:01:03,920 --> 00:01:06,860
+ال predominant cell type ال chronic myeloid
+
+13
+00:01:06,860 --> 00:01:10,800
+leukemia و chronic lymphoid leukemia و هنبدأ بال
+
+14
+00:01:10,800 --> 00:01:14,920
+chronic myeloid leukemiaواللي هي by definition هي
+
+15
+00:01:14,920 --> 00:01:18,460
+عبارة عن stem cell disorder زي ما اتفق نطوي شو
+
+16
+00:01:18,460 --> 00:01:21,400
+بيقولوا فيها؟ بيقولوا انه تتميز بوجود في الدليل
+
+17
+00:01:21,400 --> 00:01:27,040
+فيه chromosome positive موجود في كل stem cell شو
+
+18
+00:01:27,040 --> 00:01:30,280
+اللي بيصير فيها؟ ماديات بعد ذلك اللي بيصير فيها
+
+19
+00:01:30,280 --> 00:01:33,880
+replacement of normal bone marrow stem cell أو
+
+20
+00:01:33,880 --> 00:01:40,420
+cell with abnormalStem cell that have Philadelphia
+
+21
+00:01:40,420 --> 00:01:44,900
+chromosome positive شوف Philadelphia chromosome هو
+
+22
+00:01:44,900 --> 00:01:48,440
+برامج Translocation ما بين كرمزوم رقم تسعة واتنين
+
+23
+00:01:48,440 --> 00:01:55,600
+وعشرين في ال QR 34 مع ال QR 11
+
+24
+00:01:57,520 --> 00:02:02,260
+وهذه اللوكيميا تتكوّن من 6 نوعين مختلفة كرونيك
+
+25
+00:02:02,260 --> 00:02:06,440
+مايلويد لوكيميا فلادلفيا positive كرونيك
+
+26
+00:02:06,440 --> 00:02:11,140
+جرانيولاستيك لوكيميا كرونيك مايلويد لوكيميا
+
+27
+00:02:11,140 --> 00:02:16,740
+فلادلفيا negative كرونيك
+
+28
+00:02:16,740 --> 00:02:21,000
+مايلويد لوكيميا كرونيك مايلويد لوكيميامثلًا كرونك
+
+29
+00:02:21,000 --> 00:02:26,360
+نيتروفيلك لوكيميا وانكرونك إيزينوفيلك لوكيميا ثم
+
+30
+00:02:26,360 --> 00:02:32,300
+نوع السادس كرونك مايلومونوسيتك لوكيميا ما هي
+
+31
+00:02:32,300 --> 00:02:35,060
+الانسدانس لهذا المرض؟ كالكرونك مايلومونوسيتك
+
+32
+00:02:35,060 --> 00:02:40,880
+لوكيميا بتشكل 20% من كل أنواع اللوكيميا وهي أكثر
+
+33
+00:02:40,880 --> 00:02:45,960
+ندرة من كرونك رومفوسيتك لوكيميا انسدانس ريت تبعتها
+
+34
+00:02:45,960 --> 00:02:49,500
+واحد لحالة لحالتين بكل مائة ألف من ال population
+
+35
+00:02:50,640 --> 00:02:55,320
+والـ peak incidence فيها هو ال middle age people
+
+36
+00:02:55,320 --> 00:03:00,920
+طبعا ال male دايما نصيبهم أكبر من ال female ال
+
+37
+00:03:00,920 --> 00:03:05,990
+male to female ratio هي one point four to oneلكن
+
+38
+00:03:05,990 --> 00:03:09,670
+ايضا ممكن تشوف هذه في الأطفال في ال new-age and
+
+39
+00:03:09,670 --> 00:03:14,550
+very old people مش شرط ال middle-aged people لكن
+
+40
+00:03:14,550 --> 00:03:19,190
+بشكل عام ال peak incidence هو لل middle-aged
+
+41
+00:03:19,190 --> 00:03:22,610
+people شوف Philadelphia chromosome طبعا في
+
+42
+00:03:22,610 --> 00:03:26,130
+Philadelphia chromosome بتعرفوا انه هو بيصير في
+
+43
+00:03:26,130 --> 00:03:29,570
+translocation ما بين كرمزوم تسعة و اتنين و عشرين
+
+44
+00:03:29,570 --> 00:03:34,750
+ما بين ال Q arm لهذا و ال Q arm لهذاواللي بيصير
+
+45
+00:03:34,750 --> 00:03:38,670
+إنه بينتقل جزء من الـ Appelsauce بروتو أمكرجين
+
+46
+00:03:38,670 --> 00:03:46,290
+ماشي اللي موجود في كرمزوم رقم 9 إلى ال PCR region
+
+47
+00:03:46,290 --> 00:03:54,580
+اللي موجودة في كرمزوم رقم 22و أيضا جزء من ال PCR
+
+48
+00:03:54,580 --> 00:04:01,320
+تبع 22 بيروح على رقم 9 و المحصلة new chromosome و
+
+49
+00:04:01,320 --> 00:04:04,400
+ال chromosome ال abnormal ال chromosome هو بيطلع
+
+50
+00:04:04,400 --> 00:04:09,400
+22 بيكبر كتير و بيسموه Philadelphia chromosome
+
+51
+00:04:12,750 --> 00:04:20,490
+100% و طبعا هذا هو الشكل هذا تسع وهذا ماشي هذا تسع
+
+52
+00:04:20,490 --> 00:04:27,690
+وهذا اتنين و عشرين اي جزء ال APL وهي جزء ال PCR
+
+53
+00:04:27,690 --> 00:04:34,590
+ماشي ال شو اللي بيصير ان ال APL جزء منه يروح على
+
+54
+00:04:34,590 --> 00:04:42,690
+ال PCR region في اتنين و عشرينوطبعا جزء اللى هو
+
+55
+00:04:42,690 --> 00:04:48,510
+المتبقى من 22 بروح عالمين على كرمزوم رقم 9
+
+56
+00:04:48,510 --> 00:04:52,170
+وبالتالي بيصير فيه عندنا new abnormal كرمزوم اللى
+
+57
+00:04:52,170 --> 00:04:59,890
+هو رقم 22 كبير طيب ال pathogenesis يعني ال
+
+58
+00:04:59,890 --> 00:05:04,310
+hemipoietic abnormality بتاعته نتيجة expansion of
+
+59
+00:05:04,310 --> 00:05:05,810
+granulocytic progenitors
+
+60
+00:05:08,190 --> 00:05:12,530
+ماشي بتزيد عددها و بيصير فيه decrease لل
+
+61
+00:05:12,530 --> 00:05:18,550
+sensitivity of progenitor cell to regulation بتبطل
+
+62
+00:05:18,550 --> 00:05:22,690
+تتح .. يعني ترد على ال control .. ال regulatory
+
+63
+00:05:22,690 --> 00:05:27,610
+mechanism اللي موجودة decrease sensitivity للخلايا
+
+64
+00:05:27,610 --> 00:05:33,610
+البدائية to control mechanism هذا بيقضي إلى زيادة
+
+65
+00:05:33,610 --> 00:05:40,050
+في ال white cell countميجا كاليو سايتو بيويسيز
+
+66
+00:05:40,050 --> 00:05:46,710
+غالبا مثلا هي expansion لأنه مستمس الواحدة ثم
+
+67
+00:05:46,710 --> 00:05:50,970
+الارترو بيويسيز is usually deficient لإنه بيصير
+
+68
+00:05:50,970 --> 00:05:57,110
+فيه تفضيل نوع من الخلايا على حساب نوع آخر ثم ال
+
+69
+00:05:57,110 --> 00:06:00,350
+function of neutrophil and platelet is nearly
+
+70
+00:06:00,350 --> 00:06:05,450
+normal في البداية طيب من ناحية ال genetic
+
+71
+00:06:05,450 --> 00:06:12,360
+abnormality شو اللي صار؟اللي صار انه صار فيه
+
+72
+00:06:12,360 --> 00:06:17,840
+acquire genetic abnormality نتيجة ال translocation
+
+73
+00:06:17,840 --> 00:06:24,440
+ما بين كرمزوم تسعة و اتنين و عشرين و حصل انه صار
+
+74
+00:06:24,440 --> 00:06:30,790
+فيه تجمع ل PCR APL regionوعشان نعرف شو اللي صار
+
+75
+00:06:30,790 --> 00:06:36,570
+نعرف ال function of both PCR و APL these are
+
+76
+00:06:36,570 --> 00:06:43,310
+tyrosine phosphokinase enzyme they are
+
+77
+00:06:43,310 --> 00:06:50,310
+phosphokinase enzyme ماشي ومحصلة هذا الارتباط
+
+78
+00:06:50,310 --> 00:06:54,850
+تكوين protein بسموه protein 210 تحسب المملكة اللي
+
+79
+00:06:54,850 --> 00:06:59,240
+رويت تابع 210 دولاروهذا البروتين يلو function
+
+80
+00:06:59,240 --> 00:07:07,020
+جديدة في الوضع الطبيعي ال normal APL gene بيطلع
+
+81
+00:07:07,020 --> 00:07:11,480
+لنا بروتين اسم our encode for البروتين بيسمو بي
+
+82
+00:07:11,480 --> 00:07:17,300
+one four five APL مرة تانية بذكر الأقام هذه
+
+83
+00:07:17,300 --> 00:07:22,820
+denotes for the molecular weight يبقى ال APL
+
+84
+00:07:22,820 --> 00:07:26,760
+بيدينا بروتين one four five APL
+
+85
+00:07:29,180 --> 00:07:35,500
+عظيمته بشكل كامل مش مفهوم لكن بيقولوا انه بيشتغل
+
+86
+00:07:35,500 --> 00:07:41,310
+كتيروزين كاينيز activityبلعب دور كبير في
+
+87
+00:07:41,310 --> 00:07:43,690
+الregulation of several different growth factors
+
+88
+00:07:43,690 --> 00:07:48,670
+وبما فيها ال epidermal growth factor و ال platelet
+
+89
+00:07:48,670 --> 00:07:52,610
+growth factor و كل ال stimulating factor يبقى هو
+
+90
+00:07:52,610 --> 00:08:00,910
+من يتحكم بيه ال growth factor hormone او ال
+
+91
+00:08:00,910 --> 00:08:07,090
+cytokine اللي موجودة فيه في ال hemopoietic organ
+
+92
+00:08:12,800 --> 00:08:23,200
+ال PCR جين جاله ات كودز for a protein سموه P160
+
+93
+00:08:23,200 --> 00:08:29,440
+-PCR وده عبارة عن برضه كاينيز انزايم هو عبارة عن
+
+94
+00:08:29,440 --> 00:08:36,460
+serine-threonine كاينيز انزايم وتقريبا
+
+95
+00:08:37,810 --> 00:08:45,830
+يشبه كثير عدد من البروتينات الـ Cell Cycle يعني
+
+96
+00:08:45,830 --> 00:08:52,170
+Cell Cycling بروتين ويكون هناك عدو كبير في
+
+97
+00:08:52,170 --> 00:08:57,730
+Cellular Signal Transduction وبالتالي عندما تتكلم
+
+98
+00:08:57,730 --> 00:09:05,890
+عن PCR-ABL Fusion Gene هذا الكمبيونة تطلع لنا
+
+99
+00:09:05,890 --> 00:09:15,270
+بروتينملكة الويت تبع 210,000 و بيسموه P210 PCR APL
+
+100
+00:09:15,270 --> 00:09:21,850
+و بيقول ان البروتين هو كتيروزين
+
+101
+00:09:21,850 --> 00:09:29,360
+كينيز اكتر من ال P145 APLهو أيضًا يحتاج إلى عملية
+
+102
+00:09:29,360 --> 00:09:33,160
+التعامل
+
+103
+00:09:33,160 --> 00:09:41,960
+مع مجموعته بقوة أكبر تفقنا على أن البروتين اللي
+
+104
+00:09:41,960 --> 00:09:48,740
+يتكوّن من هذا الـ Translocation هو P210-PCR-ABL
+
+105
+00:09:48,740 --> 00:09:53,800
+اللي يحتاج إلى عملية التعامل مع مجموعتهوبالتالي
+
+106
+00:09:53,800 --> 00:09:56,040
+انها انزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+107
+00:09:56,040 --> 00:09:56,780
+وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+108
+00:09:56,780 --> 00:10:00,680
+وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+109
+00:10:00,680 --> 00:10:01,560
+وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+110
+00:10:01,560 --> 00:10:01,980
+وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+111
+00:10:01,980 --> 00:10:05,280
+وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج وانزعج
+
+112
+00:10:05,280 --> 00:10:11,280
+وانزعج وانزعج
+
+113
+00:10:11,280 --> 00:10:17,320
+وانزتو جيني cluster بالمناسبة بصار لهم مش fusion
+
+114
+00:10:17,320 --> 00:10:21,840
+واحد code for growth factor و growth factor
+
+115
+00:10:21,840 --> 00:10:27,400
+receptor والتاني code for a protein سلساكة لبروتين
+
+116
+00:10:27,400 --> 00:10:33,080
+لما التانين يجتمعوا مع بعض بتكونوا بروتين قوي جدا
+
+117
+00:10:33,080 --> 00:10:40,060
+وبيشتغل on both have both function وبالتالي
+
+118
+00:10:41,590 --> 00:10:45,170
+It can push the proliferation differentiation
+
+119
+00:10:45,170 --> 00:10:51,650
+process in a novel manner و بالذات في أول هذه
+
+120
+00:10:51,650 --> 00:10:56,650
+المراحل Translocation تسعة و اتنين و عشرين زي ما
+
+121
+00:10:56,650 --> 00:11:05,390
+انتوا شايفين اتنين و عشرين كان هدا هو ماشي و ساريك
+
+122
+00:11:05,390 --> 00:11:09,110
+بعد ال translocation
+
+123
+00:11:11,640 --> 00:11:16,720
+translocation أيضا صورة تانية بتوضح بالرسم الجزء
+
+124
+00:11:16,720 --> 00:11:22,060
+المنقول واحد الأجزاء هذه هي المنقولة هذه واحد
+
+125
+00:11:22,060 --> 00:11:27,240
+بروحان والتاني بجهان ماشي و هذا الجزء بروحان
+
+126
+00:11:27,240 --> 00:11:32,800
+فالتنين وعشرين واتنين وعشرين جزء بروح على على تسعة
+
+127
+00:11:32,800 --> 00:11:37,320
+طبعا
+
+128
+00:11:37,320 --> 00:11:43,990
+ال television كنيزوهو عبارة عن البروتينز بتلعب دور
+
+129
+00:11:43,990 --> 00:11:48,850
+كبير في ال signal transduction واللي بيصير في ال
+
+130
+00:11:48,850 --> 00:11:56,170
+BCR ABL هو عبارة عن تاريزين كاينيز activity و this
+
+131
+00:11:56,170 --> 00:12:01,250
+activity بتلعب دور كبير في growth advantage to the
+
+132
+00:12:01,250 --> 00:12:05,030
+lycanic cell شو بتعمل؟ يعني increase proliferation
+
+133
+00:12:05,030 --> 00:12:09,030
+and cytokine independent يعني بتبطر ترد على ال
+
+134
+00:12:09,030 --> 00:12:15,580
+growth factorبينمو نمو مطردون regulatory mechanism
+
+135
+00:12:15,580 --> 00:12:21,700
+بيصير فيه نوع من ال autonomy يعني الحكم الذاتي
+
+136
+00:12:21,700 --> 00:12:26,580
+للخلية تتحكم نفسها بنفسها أيضا بيعمل inhibition لل
+
+137
+00:12:26,580 --> 00:12:32,740
+-amortosis بيخفف
+
+138
+00:12:32,740 --> 00:12:37,020
+ال adhesion الموليكيوني وبالتالي تتحرر الخلية أكتر
+
+139
+00:12:37,020 --> 00:12:40,400
+في حركتها
+
+140
+00:12:43,500 --> 00:12:49,980
+كيف نشخص المريض الـCML؟ قالوا أول ما بيجي مريض
+
+141
+00:12:49,980 --> 00:12:55,480
+الـCML بيكون بيعاني من القادي بيبقى قاعد
+
+142
+00:12:55,480 --> 00:13:01,700
+increasing splenomegaly وطبعا لما بيكبر الـSpleen
+
+143
+00:13:01,700 --> 00:13:06,480
+بيصير فيه discomfort و pain و indigestion
+
+144
+00:13:09,040 --> 00:13:13,260
+مرة اتنين Defractory Anemia ومن صفات الانيميا ال
+
+145
+00:13:13,260 --> 00:13:17,560
+pallor و ال weakness و التاكيكارديا مرة تلاتة
+
+146
+00:13:17,560 --> 00:13:23,040
+Brosing و ممكن يصير عنده ابست بروزين يعني bleeding
+
+147
+00:13:23,040 --> 00:13:31,800
+under the skin او ابستaxis يعني
+
+148
+00:13:31,800 --> 00:13:37,620
+رعفة او bleeding from the noseنتيجة الـ Abnormal
+
+149
+00:13:37,620 --> 00:13:43,620
+Platelet Function بيصير فيه جاوت وهذا محصلة تورينا
+
+150
+00:13:43,620 --> 00:13:47,860
+ال impairment لإن فيها ايباريوريكيميا نتيجة تكسير
+
+151
+00:13:47,860 --> 00:13:56,460
+الخلائية يعني سلطانية ثم ال visual disturbances
+
+152
+00:13:56,460 --> 00:14:03,200
+اللي ممكن تحصل نتيجة الأنيميا وممكن تحصل نتيجةتجمع
+
+153
+00:14:03,200 --> 00:14:07,320
+اليوريك أسد في أماكن مختلفة من الجسم بما فيها
+
+154
+00:14:07,320 --> 00:14:14,780
+أملاح وصلة العين increase requirement to
+
+155
+00:14:14,780 --> 00:14:18,520
+chemotherapy to maintain remission كلما زاد العدد
+
+156
+00:14:18,520 --> 00:14:22,760
+تبع ال white blood cell abnormal لو كيميك سيل كلما
+
+157
+00:14:22,760 --> 00:14:28,440
+زى مريض يحتاج كيموثيرابي بكمية أكبر ثم massive
+
+158
+00:14:28,440 --> 00:14:31,780
+increase لل granulocytes
+
+159
+00:14:34,280 --> 00:14:38,220
+أكيد له كيميا انه دائما في increase في ال white
+
+160
+00:14:38,220 --> 00:14:44,480
+blood cell طيب كيف نشخص مريض ال CML يعني بنعمل CBC
+
+161
+00:14:44,480 --> 00:14:48,660
+و غالبا ال white blood cell بتكون اكتر من خمسين
+
+162
+00:14:48,660 --> 00:14:57,540
+الف وبعد مرات بتوصل اكتر من خمسمائة الف في كل
+
+163
+00:14:57,540 --> 00:15:03,700
+millimeter cube cubic millimeterوبتكون فيه انيميا
+
+164
+00:15:03,700 --> 00:15:08,880
+والانيميا هي normochromic والـ platelet في البداية
+
+165
+00:15:08,880 --> 00:15:13,920
+بتكون اما عالية واما normal واما واطية لو عملنا
+
+166
+00:15:13,920 --> 00:15:18,560
+peripheral blood هلاجي فيه زيادة في ال circulating
+
+167
+00:15:18,560 --> 00:15:23,620
+basophilوزي ما انتوا شايفين هدا هي ال glass
+
+168
+00:15:23,620 --> 00:15:29,940
+الموجودة وفيه ماتش ورسل متكلمة ده هي ماتش ورسل
+
+169
+00:15:29,940 --> 00:15:35,880
+انما ال glass ده هي موجودة في ال peripheral blood
+
+170
+00:15:35,880 --> 00:15:39,600
+و هذا في ال ambivalent blood و هذا برضه peripheral
+
+171
+00:15:39,600 --> 00:15:45,090
+bloodتشوفون نيوتروفيليا اللى موجود لكن بالاضافة
+
+172
+00:15:45,090 --> 00:15:51,450
+للنيوتروفيليا في اللى هو abnormal or immature cell
+
+173
+00:15:51,450 --> 00:16:00,170
+هى دى metamylocytes هى دى blast هى نبرو ميلو سايتس
+
+174
+00:16:00,170 --> 00:16:05,630
+وهكذا هى دول الخلايا برضه immature
+
+175
+00:16:07,160 --> 00:16:11,700
+ففيه عبارة عن فيلم بيكون mixed of mature and
+
+176
+00:16:11,700 --> 00:16:16,860
+immature self ومعظم مراحل ال maturation بتكون
+
+177
+00:16:16,860 --> 00:16:21,320
+موجودة طيب إيش فيها جواهر تشخيصية أخرى جانوا بنعمل
+
+178
+00:16:21,320 --> 00:16:27,190
+تترفيه لكلام فاسفاتيه scoringوغالبا ايش يعني يعني
+
+179
+00:16:27,190 --> 00:16:32,790
+بدأوا بسبوها بال alkaline phosphatase و ببدأ اعد
+
+180
+00:16:32,790 --> 00:16:40,450
+اللي هو الخلايا اللي ماخدة سبقها وغالبا لأنها
+
+181
+00:16:40,450 --> 00:16:45,470
+abnormal cell بيكون ال alkaline phosphatase
+
+182
+00:16:45,470 --> 00:16:49,530
+function واطيه مش موجود وبالتالي بتكون قدرتها قليل
+
+183
+00:16:49,530 --> 00:16:57,920
+البومبرو is hypercellularwith granulopoietic
+
+184
+00:16:57,920 --> 00:17:02,860
+predominance اكتر اشي لجرانيلو سايتس ولو عملنا
+
+185
+00:17:02,860 --> 00:17:09,920
+study of genetics سنشوف فلانلفيا كرومازون و ايضا
+
+186
+00:17:09,920 --> 00:17:16,820
+لو عملنا P12 and P12 binding capacity بتكون عالية
+
+187
+00:17:16,820 --> 00:17:23,350
+ليش؟هذه نقطة مهمة جدا لان اتفقنا ان ال career of
+
+188
+00:17:23,350 --> 00:17:30,190
+B12 هو من تلت أنواع النوع التاني هو significant
+
+189
+00:17:30,190 --> 00:17:38,110
+النوع الأول والتالت هدولة بيتصنعوا من ال white
+
+190
+00:17:38,110 --> 00:17:41,710
+blood cell جرانيال والجرانيال العالية فبالتالي
+
+191
+00:17:41,710 --> 00:17:45,170
+التركيز تبعهم بكون عالي وبالتالي بيمشكوا ال
+
+192
+00:17:45,170 --> 00:17:48,940
+vitamin B12 بكميات أكبرو هؤلاء هم الناس اللي
+
+193
+00:17:48,940 --> 00:17:53,140
+بيسموهم non significance اربعين دل وبالتالي
+
+194
+00:17:53,140 --> 00:17:59,120
+بيمشيكوا ال vitamin و بيبقوا مسكين فيه وبالتالي
+
+195
+00:17:59,120 --> 00:18:07,060
+تركيزهم عالي في استيران حاجة تانية نعمل يوريك أسد
+
+196
+00:18:07,060 --> 00:18:13,070
+و بيكون عالي نتيجة تكسر الخلاياما هي المراحل اللي
+
+197
+00:18:13,070 --> 00:18:17,130
+بتمر فيها الـCML؟ كانوا فيه تلت مراحل تلت مراحل
+
+198
+00:18:17,130 --> 00:18:18,230
+تلت مراحل تلت مراحل تلت مراحل تلت مراحل تلت مراحل
+
+199
+00:18:18,230 --> 00:18:21,070
+تلت مراحل تلت مراحل تلت مراحل تلت مراحل تلت مراحل
+
+200
+00:18:21,070 --> 00:18:21,690
+تلت مراحل تلت مراحل تلت مراحل تلت مراحل تلت مراحل
+
+201
+00:18:21,690 --> 00:18:21,730
+تلت مراحل تلت مراحل تلت مراحل تلت مراحل تلت مراحل
+
+202
+00:18:21,730 --> 00:18:21,790
+تلت مراحل تلت مراحل
+
+203
+00:18:40,850 --> 00:18:45,810
+الـ accelerated phase قالوا هنا بيصير في انتقال ل
+
+204
+00:18:45,810 --> 00:18:52,190
+phase تاني بيسموه accelerated متسارع و اللي بيصير
+
+205
+00:18:52,190 --> 00:18:53,970
+في هذا ال phase انه بيصير refractory
+
+206
+00:18:53,970 --> 00:18:59,450
+refractoriness to treatment بتزيد ال refractory to
+
+207
+00:18:59,450 --> 00:19:07,950
+treatment و هذا نتيجة يعني اللي هو اكتساب المريض
+
+208
+00:19:07,950 --> 00:19:12,110
+mutation جديدةوبالتالي صار فيه زيادة في ال
+
+209
+00:19:12,110 --> 00:19:17,470
+resistance to therapy ماذا يميز هذا المريض قالوا
+
+210
+00:19:17,470 --> 00:19:20,830
+في وجود 15% بلاست في ال bone marrow او ال
+
+211
+00:19:20,830 --> 00:19:25,570
+peripheral blood و اكتر وجود اكتر من 30% بلاست و
+
+212
+00:19:25,570 --> 00:19:30,470
+bromielocyte في ال peripheral blood اكتر من 20%
+
+213
+00:19:30,470 --> 00:19:38,850
+بيزوفيل و اقل من 100000 لبليتلتوهي كما قلنا اكتساب
+
+214
+00:19:38,850 --> 00:19:41,690
+لـ mutation جديدة ففي كرموزومة ال abnormality
+
+215
+00:19:41,690 --> 00:19:46,050
+جديدة ومن أشهر ال addition لكرموزومة ال
+
+216
+00:19:46,050 --> 00:19:51,610
+abnormality هي Trisomy 8 Increase
+
+217
+00:19:51,610 --> 00:19:56,130
+بيقوم معروفة في بروسس وفي
+
+218
+00:19:56,130 --> 00:20:01,930
+ال plastic phase ال plastic should exceed تلاتين
+
+219
+00:20:01,930 --> 00:20:03,430
+فالمية في البرفرالبط
+
+220
+00:20:07,560 --> 00:20:16,260
+وهذا غالبا عبارة عن evolution of CML وكأنها الـ
+
+221
+00:20:16,260 --> 00:20:21,980
+CML بتجلب لـ acute phase لأنه لما عرفنا ال acute
+
+222
+00:20:21,980 --> 00:20:26,660
+leukemia قلنا لازم يكون فيه blast بنسبة 30% فما
+
+223
+00:20:26,660 --> 00:20:31,180
+فوق في ال chronic leukemia يوم ما تجلب يوم ما يزيد
+
+224
+00:20:31,180 --> 00:20:34,320
+عدد ال blast ل 30% فما فوق تجلب ل
+
+225
+00:20:37,280 --> 00:20:42,160
+acute leukemia و بالتالي اذا وصلت لهذه المرحلة
+
+226
+00:20:42,160 --> 00:20:45,720
+بيكون المريض عنده anemia و عنده neutropenia و عنده
+
+227
+00:20:45,720 --> 00:20:51,240
+thrombocytopenia بشكل واضح plastic phase زي ما
+
+228
+00:20:51,240 --> 00:20:56,840
+قلنا في معظم الحالات ال accelerated phase بيتبعوا
+
+229
+00:20:56,840 --> 00:21:02,160
+plastic phase و طبعا في هذا ال phase بيكون
+
+230
+00:21:02,160 --> 00:21:07,440
+refractory to treatment sustained بمعنى دائمو الـ
+
+231
+00:21:07,440 --> 00:21:12,860
+Blast cell count بتزيد و ال physical symptoms
+
+232
+00:21:12,860 --> 00:21:19,880
+بتزيد شوء و ال diagnostic criteria for the blast
+
+233
+00:21:19,880 --> 00:21:22,720
+phase هو ال blast crisis
+
+234
+00:21:27,200 --> 00:21:30,980
+اللي Circulating Blast Cell Count Should Exceed 30
+
+235
+00:21:30,980 --> 00:21:36,440
+% من ال Total Leukocyte Count وزي ما قلتلكوا ده و
+
+236
+00:21:36,440 --> 00:21:40,320
+كأن ال anemia .. sorry و كأن ال chronic leukemia
+
+237
+00:21:40,320 --> 00:21:47,920
+بتجلب لمين؟ ل acute leukemia و في هذه الحالة ال
+
+238
+00:21:47,920 --> 00:21:55,250
+blast زيادة ال blast بهذا العدد المحوربيؤدي إلى
+
+239
+00:21:55,250 --> 00:22:02,110
+زيادة في الانيميا بسبب نتروبيني أو ثرومبوسيتوبيا
+
+240
+00:22:02,110 --> 00:22:09,030
+هذا جدول بيفرقلي ما بين ال تلاتة different phases
+
+241
+00:22:09,030 --> 00:22:12,650
+of chronic myeloid leukemia زي ما انتوا شايفين
+
+242
+00:22:12,650 --> 00:22:15,650
+median duration في ال chronic phase المريض ممكن
+
+243
+00:22:15,650 --> 00:22:20,010
+يعيش من خمسة لست سنوات بينما ال accelerated phase
+
+244
+00:22:20,010 --> 00:22:25,830
+تبدأ مرحلة قلو عمر ال phase هذا لا يتجاوز ستة
+
+245
+00:22:25,830 --> 00:22:32,090
+لتسعة شهور إذا دخل المريض في blast phase بصمدش
+
+246
+00:22:32,090 --> 00:22:38,630
+أكتر من تلاتة أسات شهورالـ White PCs هي عالية في
+
+247
+00:22:38,630 --> 00:22:42,370
+الـ Chronic Phase أكتر من 20 ألف وهي تستمر عالية
+
+248
+00:22:42,370 --> 00:22:47,290
+بس حسب المرحلة الزمنية اللي بتتم فيها الفحص بيكون
+
+249
+00:22:47,290 --> 00:22:50,570
+فيه زيادة في الـ White Blood Cell الـ Blast في
+
+250
+00:22:50,570 --> 00:22:55,730
+البداية بيكون سفر لكن بتبدأ تزيد لغاية ما تصل لـ
+
+251
+00:22:55,730 --> 00:23:00,550
+30% في الـ Plastic Phase اللي هو الـ Acute وكانها
+
+252
+00:23:00,550 --> 00:23:06,400
+جلبة لـ Acute بيظهر فيه العالية وهي بتستمر عاليةفي
+
+253
+00:23:06,400 --> 00:23:11,180
+البداية بتكون عالى او normal ثم في النهاية بتصير
+
+254
+00:23:11,180 --> 00:23:18,300
+decreased ال myeloid hyperplasia طبعا كل مره بيكون
+
+255
+00:23:18,300 --> 00:23:24,340
+hypercellularity of myeloid series ساتروجيناثيك في
+
+256
+00:23:24,340 --> 00:23:28,920
+لادلفيه كرمزوم في كل مراحل PCR APL positive في كل
+
+257
+00:23:28,920 --> 00:23:35,520
+ايش المراحلكيف مغالج الـCML كانوا يتعالجوا بأكتر
+
+258
+00:23:35,520 --> 00:23:40,180
+من تقنيات نمرا واحد كيموثيرابي نمرا اتنين تيروزين
+
+259
+00:23:40,180 --> 00:23:43,400
+كينيز انهيبتور نمرا تلاتة interferon alpha نمرا
+
+260
+00:23:43,400 --> 00:23:47,560
+أربع stem cell transplant والتيروزين كينيز
+
+261
+00:23:47,560 --> 00:23:52,700
+انهيبتور فده هو وبر عن علاج نعمل فيه plucking
+
+262
+00:23:52,700 --> 00:23:59,540
+للتيروزين كينيز اللي هو substrate
+
+263
+00:24:05,090 --> 00:24:11,390
+العلاج اسمه Glyvec اسمه Glyvec في الوضع الطبيعي ال
+
+264
+00:24:11,390 --> 00:24:17,130
+PCR APL ماشي ال substrate تبعه يحتاج إلى طاقة
+
+265
+00:24:17,130 --> 00:24:26,070
+تايروزينكانيز وبالتالي بيشتغل بشكل زي ما قلنا فلو
+
+266
+00:24:26,070 --> 00:24:30,460
+عملنا blocking للTyrosine Kinase Activity بمعنى
+
+267
+00:24:30,460 --> 00:24:36,320
+Blocking للـATP Source بمعنى أن البروتين لن يكون
+
+268
+00:24:36,320 --> 00:24:40,900
+فوسفوريلات وبالتالي مافيش function العلاج هذا أثبت
+
+269
+00:24:40,900 --> 00:24:47,080
+نجاعة جيدة جدا وما يميز هذا العلاج أنه هو بره عن
+
+270
+00:24:47,080 --> 00:24:52,240
+specific treatment بيشتغل لجلايفك ال receptor of
+
+271
+00:24:52,240 --> 00:24:54,880
+ash of kinase enzyme
+
+272
+00:24:57,670 --> 00:25:06,190
+البروميوزيز للـCML في الغالب تظهر تجارب
+
+273
+00:25:06,190 --> 00:25:11,110
+كيموثيرابية ممتازة في الفيز الكرونيكي لكن كل ما
+
+274
+00:25:11,110 --> 00:25:15,250
+تقدمنا في الفيزيات التانية بيصير فيها مقاومة
+
+275
+00:25:15,250 --> 00:25:21,350
+كيموثيرابية والموت عادة بيصير بسبب تغيير الأكيو
+
+276
+00:25:21,350 --> 00:25:24,970
+والهمراج
+
+277
+00:25:26,340 --> 00:25:30,740
+أو infection ونستوقف
+
+278
+00:25:30,740 --> 00:25:43,360
+ناخد استراحة زي ما انتوا شايفين في هذه النوع
+
+279
+00:25:43,360 --> 00:25:48,040
+التاني من ال chronic leukemia هو chronic
+
+280
+00:25:48,040 --> 00:25:52,570
+lymphocytic leukemiaو أنا بحكي على lymphocyte طبعا
+
+281
+00:25:52,570 --> 00:25:55,930
+chronic lymphocytic leukemia هي most common type
+
+282
+00:25:55,930 --> 00:25:59,610
+of chronic lymphoid leukemia طبعا دي يكن فرقه ما
+
+283
+00:25:59,610 --> 00:26:03,630
+بين ال chronic lymphoid و هي كل أنواع ال lympho ال
+
+284
+00:26:03,630 --> 00:26:06,610
+lymphoid leukemia و ما بين ال chronic lymphocytic
+
+285
+00:26:06,610 --> 00:26:12,910
+leukemia اللي هي ال بتخص
+
+286
+00:26:12,910 --> 00:26:19,680
+اللي احنا بنحكي عليها الآنبما ده تتميز By
+
+287
+00:26:19,680 --> 00:26:23,160
+accumulation of non-proliferative mature appearing
+
+288
+00:26:23,160 --> 00:26:29,100
+lymphocytes يعني فيه lymphocytosis accumulation of
+
+289
+00:26:29,100 --> 00:26:32,340
+non-proliferative ليش بنقول يعني ايش non
+
+290
+00:26:32,340 --> 00:26:36,420
+-proliferative or proliferationلأن الخلية يوم ما
+
+291
+00:26:36,420 --> 00:26:43,900
+تصير mature بتوقف انقساماتها mature appearing ما
+
+292
+00:26:43,900 --> 00:26:49,600
+هي mature مظهرها ك mature lymphocyte ومع انه في
+
+293
+00:26:49,600 --> 00:26:52,260
+accumulation يبقى فيه lymphocytosis وين بيصير ال
+
+294
+00:26:52,260 --> 00:26:57,020
+accumulation؟ اللي بيصير في ال blood في ال marrow
+
+295
+00:26:57,020 --> 00:27:02,000
+في ال lymph nodes في ال spleen ليش بيصير في هذه
+
+296
+00:27:02,000 --> 00:27:08,100
+المواقع؟ هذه خلية matureو هذه المواقع هي مواقع
+
+297
+00:27:08,100 --> 00:27:12,360
+وصول lymphocytes لها لأنه بعد ما تتكون في ال
+
+298
+00:27:12,360 --> 00:27:16,180
+primary lymphoid organs تنتقل هذه الخلايا إلى ال
+
+299
+00:27:16,180 --> 00:27:19,600
+secondary lymphoid organs وبالتالي من خلال ال
+
+300
+00:27:19,600 --> 00:27:23,200
+blood وبالتالي ممكن تصل ال spleen ممكن تصل ال
+
+301
+00:27:23,200 --> 00:27:30,030
+lymph nodes و هكذاماذا كاركترستيكز of CLL؟ قالوا
+
+302
+00:27:30,030 --> 00:27:36,230
+most cases the cell are monoclonal B lymphocyte
+
+303
+00:27:36,230 --> 00:27:42,210
+يعني من نوع B وعلى
+
+304
+00:27:42,210 --> 00:27:49,120
+سطحها CD5 positiveوهذا marker بيسموه marker غريب
+
+305
+00:27:49,120 --> 00:27:53,580
+موجود على سطح B lymphocyte لما حكينا المرة اللي
+
+306
+00:27:53,580 --> 00:27:56,560
+فاتت على ال markers اللي موجودة على ال B
+
+307
+00:27:56,560 --> 00:28:00,980
+lymphocytes كنا بتحمل أرقام عالية و ال T
+
+308
+00:28:00,980 --> 00:28:07,100
+lymphocyte تحمل أرقام واطية و هذا رقم أقل من عشر
+
+309
+00:28:07,100 --> 00:28:12,420
+فهو عبارة عن T cell marker لكنه موجود على سطح مين؟
+
+310
+00:28:12,420 --> 00:28:14,300
+على سطح B cell
+
+311
+00:28:17,340 --> 00:28:23,980
+الـ CLL هي عبارة عن mostly بي سل لكن ت سل ممكن تي
+
+312
+00:28:23,980 --> 00:28:26,940
+chronic lymphocytic leukemia كان okay لكنها rare
+
+313
+00:28:26,940 --> 00:28:32,740
+big incidence لل all people من ستين لتمانين سنة
+
+314
+00:28:32,740 --> 00:28:40,740
+فما فوقand it's mostly common في ال north America
+
+315
+00:28:40,740 --> 00:28:49,360
+و في أوروبا لكن it's very rare في الوسط العربي
+
+316
+00:28:49,360 --> 00:28:54,400
+اللي هو في الشرق الأوسط the orient people اللي هو
+
+317
+00:28:54,400 --> 00:29:00,140
+الناس الشرقيةaffect men twice as often as women
+
+318
+00:29:00,140 --> 00:29:04,660
+كالعادة ال male نصيبه أكتر و ال incidence rate
+
+319
+00:29:04,660 --> 00:29:09,460
+شوفوا قداش مخارنة بال chronic myeloid 300 حالة لكل
+
+320
+00:29:09,460 --> 00:29:13,900
+100 ألف حالة من ال population في ال chronic
+
+321
+00:29:13,900 --> 00:29:17,320
+myeloid leukemia دول من حالة لحالتين لكل 100 ألف
+
+322
+00:29:17,320 --> 00:29:24,080
+فهم 300 حالة لكل 100 ألف حالة من ال populationما
+
+323
+00:29:24,080 --> 00:29:27,560
+هي الكوموجينيسيا في هذه الحالة؟ قالوا ان الواقع
+
+324
+00:29:27,560 --> 00:29:35,760
+الجينيكي كان يستخدم لعبارة عن رول في عدد كبير من
+
+325
+00:29:35,760 --> 00:29:40,260
+الـ CLM. الواقع الجينيكي هو الأساس في اللي هو
+
+326
+00:29:40,260 --> 00:29:44,780
+الخلل في الكرومزومات هو الأساس للكوموجينيسيا اللي
+
+327
+00:29:44,780 --> 00:29:50,640
+بيصير. فواجهوا كلومة الكرومزومة الـ abnormality في
+
+328
+00:29:50,640 --> 00:29:56,970
+أكتر من 50% من الحالاتو أشهر هذه ال chromosome ال
+
+329
+00:29:56,970 --> 00:30:02,010
+abnormality هي عبارة عن trisomy 12 و أيضا في
+
+330
+00:30:02,010 --> 00:30:07,450
+structure abnormality chromosome 13 و 14 و 11 و
+
+331
+00:30:07,450 --> 00:30:14,730
+طبعا اي مريض بيكون عنده كاريوتيبي positive بي have
+
+332
+00:30:14,730 --> 00:30:16,670
+bad prognosis
+
+333
+00:30:23,390 --> 00:30:30,310
+المرض هو طبيعته slow progressive disease
+
+334
+00:30:32,150 --> 00:30:36,330
+و خمسة و عشرين فيلم لبنية من الحالات لما بتيجي
+
+335
+00:30:36,330 --> 00:30:41,370
+للتشخيص بتكون free of physical symptoms ما بتعاني
+
+336
+00:30:41,370 --> 00:30:46,350
+من أي physical symptoms و بتكتشف بالصدفة و لو ما
+
+337
+00:30:46,350 --> 00:30:53,730
+تكتشف بتكون فيه unexplained absolute unbearable
+
+338
+00:30:53,730 --> 00:30:59,650
+lymphocytosis يبقى هذه أول حاجة بنشوفهابكون المريض
+
+339
+00:30:59,650 --> 00:31:04,850
+عنده lymphocytosis بكون عنده either cervical or
+
+340
+00:31:04,850 --> 00:31:15,470
+subclavicular or axillary lymphadenopathy و غالبا
+
+341
+00:31:15,470 --> 00:31:20,730
+بيصاحب ال lymphadenopathy splenomegaly يعني بيكون
+
+342
+00:31:20,730 --> 00:31:25,150
+في enlargement لل lymph nodes اما في ال cervical
+
+343
+00:31:25,150 --> 00:31:33,340
+او ال subclavicular and orماشي auxiliary ماشي
+
+344
+00:31:33,340 --> 00:31:39,680
+lymph nodes مصاحب ذلك اللي هو splenomegaly يوم يخش
+
+345
+00:31:39,680 --> 00:31:44,660
+المريض في chronic fatigue طبعا في هذا الحالة خش
+
+346
+00:31:44,660 --> 00:31:50,580
+على أنيميا وبالتالي بدأ يتسوق المرض chronic
+
+347
+00:31:50,580 --> 00:31:56,580
+fatigue recurrent herb resistance infection فيor
+
+348
+00:31:56,580 --> 00:32:03,700
+neutrophil dysfunction and easy browsing لأنه فيه
+
+349
+00:32:03,700 --> 00:32:08,840
+thrombocytopenia هذه الشغلات يعني صار فيه bone
+
+350
+00:32:08,840 --> 00:32:15,080
+marrow failure طبعا نتيجة الانيميا neutropenia و
+
+351
+00:32:15,080 --> 00:32:19,340
+basal immunological dysfunction يعني تشتغلش اللي
+
+352
+00:32:19,340 --> 00:32:22,240
+بيه lymphocytes and thrombocytopenia
+
+353
+00:32:25,060 --> 00:32:31,060
+الـ hepatomegaly مرات بيكون مصاحب الـ splenomegaly
+
+354
+00:32:31,060 --> 00:32:37,620
+وال chemical lymphocytes ممكن تخزو أعضاء الجسم أو
+
+355
+00:32:37,620 --> 00:32:43,320
+أماكن في الجسم غريبة زي ال scalp اللي هو الصلع و
+
+356
+00:32:43,320 --> 00:32:48,980
+ال orbits الوجنتين subconjectiva تحت العين gums
+
+357
+00:32:48,980 --> 00:32:53,800
+pleural and lung parenchyma prostate and gonads
+
+358
+00:32:54,930 --> 00:33:04,870
+أماكن غريبة جدا ممكن تصل إليها اللي هو ال ال ال ال
+
+359
+00:33:04,870 --> 00:33:08,070
+ال ال ال ال ال
+
+360
+00:33:08,070 --> 00:33:08,230
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+361
+00:33:08,230 --> 00:33:08,650
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+362
+00:33:08,650 --> 00:33:11,710
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+363
+00:33:11,710 --> 00:33:12,450
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+364
+00:33:12,450 --> 00:33:12,550
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+365
+00:33:12,550 --> 00:33:14,610
+ال ال ال ال ال ال ال ال ال ال
+
+366
+00:33:25,070 --> 00:33:29,370
+بنسموها browsing خلّيني
+
+367
+00:33:29,370 --> 00:33:33,190
+أنا أسأل عن ال investigation of the patient يعني
+
+368
+00:33:33,190 --> 00:33:36,550
+لو بنعمل CBC بيكون الوقت blood cell عالية دايما في
+
+369
+00:33:36,550 --> 00:33:40,770
+ال chronic leukemia الوقت blood cell عالية تبقى
+
+370
+00:33:40,770 --> 00:33:44,330
+بنعمل differential و بنشوف فيه lymphocytosis و
+
+371
+00:33:44,330 --> 00:33:47,610
+بيكون فيه absolute lymphocyte count بيوصل عددها
+
+372
+00:33:47,610 --> 00:33:55,210
+لأكتر من خمسين ألف و ممكن يصل لتلاتميت ألفعند
+
+373
+00:33:55,210 --> 00:33:59,850
+المريض or even more مريض بيهاني من أنيميا
+
+374
+00:33:59,850 --> 00:34:05,650
+والأنيميا بتكون normochromic واللي ممكن تتطور في
+
+375
+00:34:05,650 --> 00:34:13,130
+مراحل قادمة مع المرض ثم بيكون في autoimmune
+
+376
+00:34:13,130 --> 00:34:19,300
+hemolysis يعني autoimmune hemolytic أنيمياالـ
+
+377
+00:34:19,300 --> 00:34:22,860
+Platelet و هذه من مضاعفات الـ Autoimmune
+
+378
+00:34:22,860 --> 00:34:25,300
+Hemorrhagic Anemia من مضاعفات هذا النوع من
+
+379
+00:34:25,300 --> 00:34:31,940
+اللوكيميا Platelet بيكون فواطية غالبا بيكون فيه
+
+380
+00:34:31,940 --> 00:34:36,420
+Thrombocytopenic status لو قبلنا blood film هنلاقي
+
+381
+00:34:36,420 --> 00:34:42,400
+70 ل 99% من الوقت blood cell هي mature lymphocytes
+
+382
+00:34:42,400 --> 00:34:48,440
+و هنلاحظفي حاجة بيسموها Smudge Cell او Smear Cell
+
+383
+00:34:48,440 --> 00:34:52,960
+خلايا مفغصة are present ليش؟ لأن الـ lymphocyte is
+
+384
+00:34:52,960 --> 00:34:58,240
+in fragile cell وبالتالي لما تيجي تعمل Smear ماشي
+
+385
+00:34:58,240 --> 00:35:04,000
+عدد كبير من الخلايا ستكون Smudged Immunopheno
+
+386
+00:35:04,000 --> 00:35:10,320
+typically بنلاحظ انه في بي cell marker زي CD19
+
+387
+00:35:10,320 --> 00:35:16,880
+positiveو أيضا في حاجة بيسموها Light Chain اللي هو
+
+388
+00:35:16,880 --> 00:35:20,580
+Light
+
+389
+00:35:20,580 --> 00:35:25,850
+Chain موجودة في الخلاياتعرفين انه Lighted Chain of
+
+390
+00:35:25,850 --> 00:35:28,550
+Immunoglobulin انت عارفين ان ال B lymphocytes
+
+391
+00:35:28,550 --> 00:35:33,010
+بتصنع antibody و بتصنع ال heavy chain ثم ال
+
+392
+00:35:33,010 --> 00:35:35,830
+lighted chain ثم بتجمعهم مع بعض و تكون antibody
+
+393
+00:35:35,830 --> 00:35:40,730
+ففي الاخر بيكون و هدي ماتش وسل في الاخر بيكون في
+
+394
+00:35:40,730 --> 00:35:46,310
+lighted chain كتيرة لسه ما اتجمعت في الخلية ايضا
+
+395
+00:35:46,310 --> 00:35:50,430
+من ال immunophenotyping بيكون في CD5 positive و
+
+396
+00:35:50,430 --> 00:35:57,530
+CD13 positiveوزادة فيلم ل .. اللي هو chronic
+
+397
+00:35:57,530 --> 00:36:00,790
+lymphocytic leukemia كلها انفسايد وهي الـ smudge
+
+398
+00:36:00,790 --> 00:36:05,730
+cell اللي احنا بنحكي عليها هي .. هي .. هي .. هيشي
+
+399
+00:36:05,730 --> 00:36:12,350
+.. هي .. هي ورا الخلايا .. فلص ال bone marrow
+
+400
+00:36:12,350 --> 00:36:15,650
+aspiration بيكون في lymphocytic replacement of
+
+401
+00:36:15,650 --> 00:36:19,230
+normal marrow ولو عملنا immunoglobulin
+
+402
+00:36:19,230 --> 00:36:21,750
+electrophoresis هنلاقي قلة في ال normal
+
+403
+00:36:21,750 --> 00:36:28,250
+immunoglobulinو بيتطور او بيزداد كل ما ازداد المرض
+
+404
+00:36:28,250 --> 00:36:34,090
+سايتو جيناتيكلي هيكون اربع most important
+
+405
+00:36:34,090 --> 00:36:37,370
+chromosome ال abnormality في اربع chromosome
+
+406
+00:36:37,370 --> 00:36:46,860
+deletion of 13Q14 عيزم 12 و 11Q23وغالبا يكونوا
+
+407
+00:36:46,860 --> 00:36:54,880
+مصحوبين ب structure abnormality ل 17P وهذا المكان
+
+408
+00:36:54,880 --> 00:37:03,460
+اللي في ال B53 جين هو tumor suppressor gene طيب
+
+409
+00:37:03,460 --> 00:37:11,120
+ايضا استكملا للتشخيص كيف نقرر ال clonality او نحدد
+
+410
+00:37:11,120 --> 00:37:17,750
+ال clonality of Bاللي بتمثل 99% من الحالات or T
+
+411
+00:37:17,750 --> 00:37:23,050
+اللي بتمثل 1% من الحالات جالو في ال B cell ال
+
+412
+00:37:23,050 --> 00:37:30,190
+Clonality بتؤكد بالآتي ماشي بدأت انا اقول ان والله
+
+413
+00:37:30,190 --> 00:37:34,570
+هذه الخلايا اللي موجودة هي برعنة B lymphocyte كيش
+
+414
+00:37:34,570 --> 00:37:38,960
+بتعمل عشان اؤكد هذا التشخيصأولا نمرة واحد بدي أدور
+
+415
+00:37:38,960 --> 00:37:44,240
+على ال expression of either كعبة or لمدة lighted
+
+416
+00:37:44,240 --> 00:37:48,620
+chain هذه أنواع ال lighted chain of immunoglobulin
+
+417
+00:37:48,620 --> 00:37:55,680
+وين on cell surface membrane نمرة اتنين طبعا هذا
+
+418
+00:37:55,680 --> 00:37:59,080
+الكلام موجود في ال B-lymphocyte مش موجود في ال D
+
+419
+00:37:59,080 --> 00:38:02,420
+-lymphocyte نمرة اتنين presence of unique
+
+420
+00:38:02,420 --> 00:38:07,290
+idiotypic specificityon the immunoglobulin
+
+421
+00:38:07,290 --> 00:38:10,630
+produced by CLL cells ايش يعني ايديوتيبيكي
+
+422
+00:38:10,630 --> 00:38:16,070
+specificity يعني ان الانتيبادي يتكون من جزئين جزء
+
+423
+00:38:16,070 --> 00:38:22,110
+بيسموه الفاب وجزء بيسموه ال Fc الفاب هو مناطق
+
+424
+00:38:22,110 --> 00:38:30,150
+ارتباط الانتيبادي بالانتيجن وكل انتيبادي موجود في
+
+425
+00:38:30,150 --> 00:38:35,440
+الجسمB is specific only for one antigen وبالتالي
+
+426
+00:38:35,440 --> 00:38:39,740
+الفئة الريجين بتختلف between antibody بيسموا هذه
+
+427
+00:38:39,740 --> 00:38:48,240
+الاختلافات Idiotypic specificity فانا بأكدها و
+
+428
+00:38:48,240 --> 00:38:51,840
+بدور عليها و بلاقي ان الينوغلابيلين are idiotypic
+
+429
+00:38:51,840 --> 00:38:54,200
+in their specificity
+
+430
+00:38:57,020 --> 00:38:59,540
+برضه بفحص ال immunoglobulin gene rearrangement
+
+431
+00:38:59,540 --> 00:39:05,340
+ماهي أصلا جينات تتصفت عن تكوين ال immunoglobulin
+
+432
+00:39:05,340 --> 00:39:09,980
+جينات ال immunoglobulin تتصفت في كل مرة تصفيتها
+
+433
+00:39:09,980 --> 00:39:13,380
+مختلفة وبالتالت تدينها antibody مختلف في كل مرة
+
+434
+00:39:14,450 --> 00:39:22,290
+نقرأ أربعة typical B-cell CLL على سطح C-D19
+
+435
+00:39:22,290 --> 00:39:26,110
+positive و C-D5 positive يبقى دول الأربع شغلات
+
+436
+00:39:26,110 --> 00:39:29,830
+اللي ممكن أنا أؤكد من خلالهم ال chronality أو B
+
+437
+00:39:29,830 --> 00:39:37,210
+-cell CLL عشر على خمسة و عشرين فمية من المرضى of
+
+438
+00:39:37,210 --> 00:39:42,760
+CLL بيصير عندهم autoimmune hemolytic anemiaولو
+
+439
+00:39:42,760 --> 00:39:47,820
+فحصنا ال cost test هنلاقي positive والحاجة التانية
+
+440
+00:39:47,820 --> 00:39:51,760
+انه ال marrow aspiration لما أسحب bone marrow
+
+441
+00:39:51,760 --> 00:39:57,600
+هلاقي فيه lymphoid plus الاكتر من تلاتين في المية
+
+442
+00:39:57,600 --> 00:40:05,580
+من الخلايا يعبر عن lymphoid ال classification جاني
+
+443
+00:40:05,580 --> 00:40:14,920
+ال PCLعلى سطح CD5 بوزيتف و CD19 و 21 و 22 بوزيتف و
+
+444
+00:40:14,920 --> 00:40:20,540
+HLA-DR بوزيتف HLA هو عبارة عن human leukocyte
+
+445
+00:40:20,540 --> 00:40:28,280
+antigen من نوع DR من نوع DR ايش هو هذا هذا عبارة
+
+446
+00:40:28,280 --> 00:40:35,540
+عن اللي هو human عبارة عن MHC gene MHC gene
+
+447
+00:40:35,540 --> 00:40:35,960
+product
+
+448
+00:40:39,330 --> 00:40:43,670
+طبعاً الـ Antigen Density على الـ BCL هو أسلوك
+
+449
+00:40:43,670 --> 00:40:47,130
+أكتر من الانفسايت الطبيعي جداً كلما تحولت الخلية
+
+450
+00:40:47,130 --> 00:40:53,910
+إلى لوكيمكسل كلما فقدت ماشي جزء كبير من اللي هو
+
+451
+00:40:53,910 --> 00:40:57,070
+الـ Antigen Density اللي هو الـ cell surface
+
+452
+00:40:57,070 --> 00:41:03,450
+molecule اللي على سطحها وهذه أحد الطرق التي يعني
+
+453
+00:41:03,450 --> 00:41:07,530
+تتهرب ال لوكيمكسل من ال immune response
+
+454
+00:41:09,820 --> 00:41:15,260
+نقطة تالتة الـ CLL سل على سطحها CD25 وده عبارة عن
+
+455
+00:41:15,260 --> 00:41:22,660
+IL-2 ريسبتور ماشي it will express it weakly احنا
+
+456
+00:41:22,660 --> 00:41:26,760
+قلنا هذه الخلية تتحرر من ال control mechanism ومن
+
+457
+00:41:26,760 --> 00:41:29,780
+يتحكم بال B-lymphocyte غالبا T-lymphocytes
+
+458
+00:41:29,780 --> 00:41:34,440
+وبالتالي من خلال ال receptor هذا وبالتالي لما بيقل
+
+459
+00:41:34,440 --> 00:41:38,080
+ال receptor هذا بتقطع ال T-lymphocyte تأثر في ال B
+
+460
+00:41:39,920 --> 00:41:47,440
+CD5 هو عبارة عن Pan T Cell Marker موجود على كل الـ
+
+461
+00:41:47,440 --> 00:41:51,980
+T-Lymphocytes وملعبون
+
+462
+00:41:51,980 --> 00:41:57,260
+كبير في الـ T Cell Activation ومن هذا المنطلق
+
+463
+00:41:57,260 --> 00:42:01,080
+وجوده على الـ T-Lymphocytes قالوا إنه من هذا
+
+464
+00:42:01,080 --> 00:42:06,700
+المنطلق بيصير فيه Autoimmune Disease as a
+
+465
+00:42:06,700 --> 00:42:08,860
+complication of BCLL
+
+466
+00:42:11,060 --> 00:42:17,280
+وهذا الفيجرر بيبين لي ال pathophysiology of CLL
+
+467
+00:42:17,280 --> 00:42:24,240
+ماشي هذا هو بيتميز بالهاتف كنا تعريف ال CLL بيصير
+
+468
+00:42:24,240 --> 00:42:27,960
+accumulation فيها of long lived and poorly
+
+469
+00:42:27,960 --> 00:42:32,240
+functioning lymphocyte هذا هي لما بيصير هذا الكلام
+
+470
+00:42:32,930 --> 00:42:36,470
+يعني اللي هو هذا بيضرب في أربع اتجاهات مختلفة
+
+471
+00:42:36,470 --> 00:42:41,810
+الأولاني هذه الخلايا بتتخذ ال lymph nodes فبصير
+
+472
+00:42:41,810 --> 00:42:46,290
+infiltration لل lymph nodes وقولنا هذه اول يعني
+
+473
+00:42:46,290 --> 00:42:49,370
+diagnostic tool ممكن نستخدمها انه نتحسس ال lymph
+
+474
+00:42:49,370 --> 00:42:54,070
+nodes بالاجهية الارش وبيصير فيه massive adenopathy
+
+475
+00:42:54,070 --> 00:43:01,080
+ماشي المرة اتنيناللي دايمًا بيبقى دينوباثي او ال
+
+476
+00:43:01,080 --> 00:43:03,820
+lymph node اللي عارف منك is associated with
+
+477
+00:43:03,820 --> 00:43:08,640
+splenomegaly ويوم يكون فيه splenomegaly بيكبر ال
+
+478
+00:43:08,640 --> 00:43:13,380
+splen ماشي بيصير ظاهرة بيسموها hypersplenism ايش
+
+479
+00:43:13,380 --> 00:43:17,260
+بيصير في ال hypersplenism؟كانوا بيخزن كميات كبيرة
+
+480
+00:43:17,260 --> 00:43:21,520
+من الخلايا لإن واحد وظائف الـSpleen هو التخزين
+
+481
+00:43:21,520 --> 00:43:25,800
+كمان بالإضافة ليه اللي هو العمل المناعي أو الوظيفة
+
+482
+00:43:25,800 --> 00:43:30,220
+المناعية له، اللي خمس، ست وظائف مختلفة طب لما
+
+483
+00:43:30,220 --> 00:43:33,440
+بيصير فيها hypersplenism، شو يعني؟ خزن خلايا زيدها
+
+484
+00:43:33,440 --> 00:43:36,360
+لجوه، فقل عددها في ال peripheral blood فصار في
+
+485
+00:43:36,360 --> 00:43:42,630
+أنهينيا، ثم بوسيطوبينيا، أنيوتروبيليوماشي و طبعا
+
+486
+00:43:42,630 --> 00:43:46,490
+هذه اذا صارت بيصير فيها hemorrhage و اذا صار فيها
+
+487
+00:43:46,490 --> 00:43:49,610
+hemorrhage بيتقل الخلايا اكتر و اكتر فبالتالي
+
+488
+00:43:49,610 --> 00:43:59,030
+بتزيد .. بتزيد سوء هذه المظاهر الاتجاه
+
+489
+00:43:59,030 --> 00:44:03,810
+التالت اللي بيضرب في المرض هذا انه بيصير فيه
+
+490
+00:44:03,810 --> 00:44:08,890
+bomber و replacement of the normal cell by
+
+491
+00:44:08,890 --> 00:44:13,570
+abnormal cellوطبعاً يعني بيصير فيه bomber و
+
+492
+00:44:13,570 --> 00:44:16,990
+failure يعني انهي من thrombocytopenia انيوتروبينيا
+
+493
+00:44:16,990 --> 00:44:23,290
+وبرضه اذا صارت هزير فيه hemorrhage وزيد قلة هذه
+
+494
+00:44:23,290 --> 00:44:29,530
+الخلايا فبزيد المظاهر سواء الذنب الرابع اللي بتدرد
+
+495
+00:44:29,530 --> 00:44:34,150
+فيه اللي هو بدرد في هذا المرض كنا بيصير فيه
+
+496
+00:44:34,150 --> 00:44:37,900
+autoimmune disease كيف؟بيصير فيه impairment لل
+
+497
+00:44:37,900 --> 00:44:40,860
+immunological activity بيبطل عنده مناعة للمريض
+
+498
+00:44:40,860 --> 00:44:45,360
+وبيبطل عنده مناعة لأنه بتقل ال immunoglobulin
+
+499
+00:44:45,360 --> 00:44:49,820
+الطبيعية بيصير فيه hypogamaglobulinemia ولأن
+
+500
+00:44:49,820 --> 00:44:52,720
+الخلايا اللي تحولت إلى cancer cell يعني non
+
+501
+00:44:52,720 --> 00:44:58,430
+functioning cell فبيصير المريض عنده infectionوبصير
+
+502
+00:44:58,430 --> 00:45:02,430
+عنده Autoimmune Phenomena وقلنا ممكن يكون Antibody
+
+503
+00:45:02,430 --> 00:45:06,250
+against his RBC's فبصير فيه Autoimmune Hemolytic
+
+504
+00:45:06,250 --> 00:45:12,750
+Anemia او Antibody against his Blatelet بصير فيه
+
+505
+00:45:12,750 --> 00:45:16,990
+حد بيسموها Idiopathic Thrombocytopenic Pairup او
+
+506
+00:45:16,990 --> 00:45:22,470
+Antibody ضد النيتروفيل تبعته وبصير فيه Immune
+
+507
+00:45:22,470 --> 00:45:24,390
+Neutropenia
+
+508
+00:45:26,590 --> 00:45:31,410
+وهي المراحل المرضية لهذا المرض قالوا الـ staging
+
+509
+00:45:31,410 --> 00:45:34,490
+is very important for the prognosis and treatment
+
+510
+00:45:34,490 --> 00:45:39,690
+بهم جدا يعرفوا في أي مرحلة من المراحل لأي مرحلة
+
+511
+00:45:39,690 --> 00:45:46,610
+وصل للمريض عند التشخيص في هذا المرض وبالتالي
+
+512
+00:45:46,610 --> 00:45:50,090
+اعتمدوا two staging system واحد اسمه Rhea والتاني
+
+513
+00:45:50,090 --> 00:45:57,450
+اسمه pilotوالمرض يمر في خمس مراحل مختلفة مرحلة
+
+514
+00:45:57,450 --> 00:46:02,310
+Zero فقط المريض بيجي نابل lymphocytosis بيكون أكتر
+
+515
+00:46:02,310 --> 00:46:11,690
+من 150 ألف نمرة واحد بيكون بيجي المريض ب Stage
+
+516
+00:46:11,690 --> 00:46:16,990
+Zero يعني lymphocytosis وفي lymph node enlargement
+
+517
+00:46:16,990 --> 00:46:22,430
+بيكون في مرحلة واحد مرحلة Stage Twoيكون هناك
+
+518
+00:46:22,430 --> 00:46:30,730
+lymphocytosis و liver or endisplane بالاضافة
+
+519
+00:46:30,730 --> 00:46:37,830
+للأدينوباتي lymph node enlargement Stage
+
+520
+00:46:37,830 --> 00:46:44,350
+3 يكون هناك lymphocytosis و أنيميا أورجانوميجا
+
+521
+00:46:44,350 --> 00:46:49,170
+لأور أدينوباتي Stage 4 يكون هناك Stage Zero
+
+522
+00:46:49,170 --> 00:46:54,810
+lymphocytosis يعنيمع Thrombocytopenia بالإضافة للـ
+
+523
+00:46:54,810 --> 00:46:59,110
+Organomegaly وRadenopathy يبقى خمس مراحل مختلفة
+
+524
+00:46:59,110 --> 00:47:06,850
+حكاها المجموعة RIA في بانية Classification قالوا
+
+525
+00:47:06,850 --> 00:47:10,230
+المرض بدنا نعمله Classification لتلت مراحل مش خمس
+
+526
+00:47:10,230 --> 00:47:16,430
+مراحل Stage A وB وC في A ومعظم المرضى بيتشخصوا في
+
+527
+00:47:16,430 --> 00:47:21,530
+هذه المرحلة خمسين لستين فالمية من المرضىبيتشخصوا
+
+528
+00:47:21,530 --> 00:47:26,990
+في هذه المرحلة بيكون عنده organomegaly ماشي في
+
+529
+00:47:26,990 --> 00:47:32,190
+stage zero او واحد او اتنين منطقة واحد سفر او واحد
+
+530
+00:47:32,190 --> 00:47:35,130
+او اتنين ايش يعني سفر يعني lymphocytosis ايش يعني
+
+531
+00:47:35,130 --> 00:47:38,910
+واحد يعني adenopathy او اتنين liver or spleen
+
+532
+00:47:38,910 --> 00:47:44,290
+والهيموجلبين وال platelets لسات ما اتأثروش بيه
+
+533
+00:47:44,290 --> 00:47:47,070
+تلاتين في المية من المرضى بيجوا في هذه المرحلة
+
+534
+00:47:47,530 --> 00:47:51,370
+بتشخصوا في هذه المرحلة وبيكون عنده تلاتة او اربعة
+
+535
+00:47:51,370 --> 00:48:00,730
+او خمس مناطق مصابة ماشي و ببدأ لسه ال anemia و ال
+
+536
+00:48:00,730 --> 00:48:04,470
+cytopenia و ال thrombocytopenia ما اتأثروش
+
+537
+00:48:04,470 --> 00:48:09,150
+فالهمغلوبين اكتر من عشرة و ال platelet اكتر من
+
+538
+00:48:09,150 --> 00:48:14,550
+مائة الف و stress ي اقل من عشرين فمية من الحالات
+
+539
+00:48:14,550 --> 00:48:19,560
+بتشخصوا في هذه الحالةبغض النظر عن مناطق الإصابة
+
+540
+00:48:19,560 --> 00:48:26,600
+بيكون ال hemoglobin بدأ يتأثر صار عنده anemia و
+
+541
+00:48:26,600 --> 00:48:30,580
+صار عنده thrombocytopenia ال platelet أقل من 100
+
+542
+00:48:30,580 --> 00:48:39,500
+ألف treatment يعني ال treatment مافي شفاقة في هذا
+
+543
+00:48:39,500 --> 00:48:48,920
+المرض و the only hopeفقط ال symptom control احنا
+
+544
+00:48:48,920 --> 00:48:54,640
+بنتحكم بنخفف ال symptoms عند المريض طيب ال
+
+545
+00:48:54,640 --> 00:48:58,880
+indication for treatment قالوا نمرا واحد اذا كان
+
+546
+00:48:58,880 --> 00:49:02,980
+بدى يعانى وقتش يعني لازم انا ابدأ علاج نمرا واحد
+
+547
+00:49:02,980 --> 00:49:07,160
+اذا كان في trouble sub organomegaly في عضو من
+
+548
+00:49:07,160 --> 00:49:12,930
+الأعضاء المصعبةبدأ يزعجوا نمرة اتنين في hemolytic
+
+549
+00:49:12,930 --> 00:49:17,910
+episodes يعني في autoimmune hemolytic anemia نمرة
+
+550
+00:49:17,910 --> 00:49:22,950
+تلاتة بعمل bone marrow suppression عشان اخفف من
+
+551
+00:49:22,950 --> 00:49:30,630
+زيادة او زيادة المهولة في ال white blood cell ال
+
+552
+00:49:30,630 --> 00:49:34,090
+modality of treatment انا مش راح ادبج كتير على
+
+553
+00:49:34,090 --> 00:49:39,750
+العلاجات اللي بياخدوهابس خلّينا نذكرهم فبيعتوا
+
+554
+00:49:39,750 --> 00:49:46,090
+chemotherapy تفصيلاته مش مطلوبة منك او منك بيعملوا
+
+555
+00:49:46,090 --> 00:49:51,150
+radiotherapy للعضو المصاب عشان يخففوا من حجمه سواء
+
+556
+00:49:51,150 --> 00:49:55,510
+كان lymph nodes او spleen او liver بيعملوا .. بدوا
+
+557
+00:49:55,510 --> 00:50:02,190
+monoclonal antibody يعني antibody against اللي هو
+
+558
+00:50:05,690 --> 00:50:10,830
+different types ماشي من الزيادات فبيعتوا Anti-CD
+
+559
+00:50:10,830 --> 00:50:21,770
+52 وبيعتوا Retoximab او Anti-CD 20 وهذا بيقلل من
+
+560
+00:50:21,770 --> 00:50:28,930
+ايش من ال effect of evolved
+
+561
+00:50:28,930 --> 00:50:31,810
+اللي هو cells or
+
+562
+00:50:34,560 --> 00:50:41,560
+بعد مرات بيكون فيه antibody abnormal antibody
+
+563
+00:50:41,560 --> 00:50:46,920
+بيعملوا splenectomy بيشيلوا ال spleen لإنه بيكون
+
+564
+00:50:46,920 --> 00:50:53,600
+فيه painful and bulky spleen عند المريض ويبعتوا
+
+565
+00:50:53,600 --> 00:50:56,840
+immunoglobulin replacement يعني بيزودوا المريض ب
+
+566
+00:50:56,840 --> 00:50:59,800
+immunoglobulin لإنه ماعنده immunoglobulin كل
+
+567
+00:50:59,800 --> 00:51:05,120
+الخلايا غير طبيعية ولا تستطيعتكون normal
+
+568
+00:51:05,120 --> 00:51:10,120
+immunoglobulin طبعا ال stem cell transplant هذا
+
+569
+00:51:10,120 --> 00:51:13,700
+under clinical trial في الغالب بيعملهوش للمرضى لأن
+
+570
+00:51:13,700 --> 00:51:17,020
+المريض بيكون قولنا هذا المرض بيصيب لاختيارية
+
+571
+00:51:17,020 --> 00:51:21,380
+وبالتالي المريض لن يستطيع ان يتحمل stem cell
+
+572
+00:51:21,380 --> 00:51:26,800
+transplantation برقموزز 50% من الحالات will
+
+573
+00:51:26,800 --> 00:51:31,940
+receive partial remission ويعني بيخش في شفاء جزئي
+
+574
+00:51:32,580 --> 00:51:39,880
+أقل من 30% من الحالات ستحصل على تمييل تمام و 30%
+
+575
+00:51:39,880 --> 00:51:43,920
+من الحالات ستحصل على تدخل لـ Pro-Lymphocytic
+
+576
+00:51:43,920 --> 00:51:48,640
+Leukemia 5% من الحالات ستدخلوا في سندروم يسمونه
+
+577
+00:51:48,640 --> 00:51:53,460
+ريختر سندروم وهذا عبارة عن عندما تدخل إلى مكان
+
+578
+00:51:53,460 --> 00:51:59,820
+الليمف نود وتعشش في الليمف نود يسمون هذه دائرة
+
+579
+00:51:59,820 --> 00:52:05,370
+ريختر سندرومبهيك بنكون خلصنا ال chronic myeloid
+
+580
+00:52:05,370 --> 00:52:09,150
+leukemia و chronic lymphocytic leukemia و ناخد لنا
+
+581
+00:52:09,150 --> 00:52:13,090
+مثال او مثالين على ال pro lymphocytic leukemia من
+
+582
+00:52:13,090 --> 00:52:15,710
+الاسم pro lymphocytic leukemia هذا عبارة عن ال
+
+583
+00:52:15,710 --> 00:52:18,630
+chronic types of leukemia طبعا ال pro lymphocytic
+
+584
+00:52:18,630 --> 00:52:21,970
+leukemia يعني اللي pro lymphocyte هي المصابة ال
+
+585
+00:52:21,970 --> 00:52:26,450
+pro lymphocyte يعني اللي في ال maturationmyelocyte
+
+586
+00:52:26,450 --> 00:52:30,410
+وقلنا هذه المرحلة هي مرحلة اكبر من ال myeloblast
+
+587
+00:52:30,410 --> 00:52:35,190
+وبالتالي severity of disease هيكون اكتر ماشي it's
+
+588
+00:52:35,190 --> 00:52:39,650
+the second most common بيمثل حوالي عشرة فمية من ال
+
+589
+00:52:39,650 --> 00:52:45,110
+B cell الاجنانسي و ال incidence في الميل اكتر من
+
+590
+00:52:45,110 --> 00:52:50,510
+الفيميل ال T type T problem في سنة الكليكيميا بشكل
+
+591
+00:52:50,510 --> 00:52:56,040
+حوالي ربع الحالةالـ Leukomagenesis طبعا في نفس
+
+592
+00:52:56,040 --> 00:52:59,700
+الكرمزومة الـ abnormality اللى توا حاكين عليها 11
+
+593
+00:52:59,700 --> 00:53:06,720
+و 14 و 13 ماشي حالي 50 ل 75% من ال translocation
+
+594
+00:53:06,720 --> 00:53:13,400
+بتوصيب ال BCL1 Oncogenمشي واحدة هو مكان تكوين ال
+
+595
+00:53:13,400 --> 00:53:19,480
+heavy chain gene اللي مسؤول عن ال heavy chain
+
+596
+00:53:19,480 --> 00:53:24,560
+immunoglobulin product
+
+597
+00:53:24,560 --> 00:53:32,280
+كمان في الأو كرمزوم 14Q332 هذه برضه منطقة بيصير
+
+598
+00:53:32,280 --> 00:53:37,540
+فيها expression ل بيه lymphocyte growth factor لما
+
+599
+00:53:37,540 --> 00:53:41,200
+بتنضرب يعني بيبطل فيه بيه lymphocyte growth factor
+
+600
+00:53:41,200 --> 00:53:45,520
+في other cytogenetic abnormality زي ما قلت لكوا في
+
+601
+00:53:45,520 --> 00:53:52,880
+Trisomy 12 في اللي هو rearrangement of 3B 11B and
+
+602
+00:53:52,880 --> 00:54:01,140
+12B بالمقارنةمابين الـ TBLL و الـ PBLL TBLL كرمزوم
+
+603
+00:54:01,140 --> 00:54:09,100
+الأبنرمالتي بنشوفها في الـ 14Q1111 في منطقة مسئولة
+
+604
+00:54:09,100 --> 00:54:15,040
+عن الـ T cell receptor Alpha chain geneو هذه الـ
+
+605
+00:54:15,040 --> 00:54:18,100
+Abnormality طبعاً هي هذه ال frequency of أكتر من
+
+606
+00:54:18,100 --> 00:54:23,260
+خمسين فمية من حاليات ال TBLL
+
+607
+00:54:23,260 --> 00:54:28,620
+recognition وجود أكتر من خمس و خمسين فمية فمه Pro
+
+608
+00:54:28,620 --> 00:54:32,560
+lymphocytes في ال peripheral blood at presentation
+
+609
+00:54:33,440 --> 00:54:36,880
+و طبعا هذه خلية عبارة عن خلية أكبر larger than
+
+610
+00:54:36,880 --> 00:54:42,200
+lymphocytes و abundance of cytoplasm و بيكون فيها
+
+611
+00:54:42,200 --> 00:54:46,900
+condensed chromatin material prominent nucleolus و
+
+612
+00:54:46,900 --> 00:54:54,960
+هذا هي شكل ال pro lymphocytic leukemia طبعا ال pro
+
+613
+00:54:54,960 --> 00:54:59,720
+lymphocytic leukemia بتتميز
+
+614
+00:54:59,720 --> 00:55:04,560
+بوجود raised white blood cellبوصل للعدد الاقل من
+
+615
+00:55:04,560 --> 00:55:12,660
+مائة الف لكن ممكن يصل لعشر مليون ماشي وبالتالي
+
+616
+00:55:12,660 --> 00:55:20,320
+طبعا معظمها Pro lymphocytes ال TBLL بتكون مشهورة
+
+617
+00:55:20,320 --> 00:55:25,620
+بزيادة white blood cell اكتر من BLLمعظم الحالات
+
+618
+00:55:25,620 --> 00:55:29,800
+عندهم Trombocytopenia and anemia secondary to P
+
+619
+00:55:29,800 --> 00:55:33,440
+bone marrow infiltration sphenomegaly where bone
+
+620
+00:55:33,440 --> 00:55:38,480
+marrow is characteristics it's
+
+621
+00:55:38,480 --> 00:55:42,160
+not needed في الغالب لا نحتاجه for diagnosis إلا
+
+622
+00:55:42,160 --> 00:55:48,310
+عشان أفرق بين ال P و البلال و Tblal جالوا في ال B
+
+623
+00:55:48,310 --> 00:55:53,610
+بلال
+
+624
+00:55:53,610 --> 00:55:57,430
+الخلية بتكون large و pale blue و not granular
+
+625
+00:55:57,430 --> 00:56:01,450
+cytoplasm و يكون في single nucleus و single
+
+626
+00:56:01,450 --> 00:56:07,380
+nucleusبينما الـ TPLL بتكون slightly smaller وفيه
+
+627
+00:56:07,380 --> 00:56:11,800
+regular nucleus وغالبا بيكون clifted and slightly
+
+628
+00:56:11,800 --> 00:56:15,020
+more mesophilic cytoplasm with a zoophilic
+
+629
+00:56:15,020 --> 00:56:19,320
+granules وهذه فروقات ما بين ال amino phenotyping
+
+630
+00:56:19,320 --> 00:56:24,800
+of P, PLL وTPLL زي ما انتوا شايفين ال P مخد
+
+631
+00:56:24,800 --> 00:56:29,360
+الأرقام العالية وT مخد الأرقام الواطيةالـ
+
+632
+00:56:29,360 --> 00:56:35,100
+Pathophysiology زيادة الـ lymphocyte count بزيادة
+
+633
+00:56:35,100 --> 00:56:37,060
+بشكل كبير بشكل كبير بشكل كبير بشكل كبير بشكل كبير
+
+634
+00:56:37,060 --> 00:56:38,400
+بشكل كبير بشكل كبير بشكل كبير بشكل كبير بشكل كبير
+
+635
+00:56:38,400 --> 00:56:41,260
+بشكل كبير بشكل كبير بشكل كبير بشكل كبير بشكل كبير
+
+636
+00:56:41,260 --> 00:56:43,640
+بشكل كبير بشكل كبير بشكل كبير بشكل كبير بشكل كبير
+
+637
+00:56:43,640 --> 00:56:48,380
+بشكل كبير بشكل كبير بشكل كبير بشكل كبير بشكل كبير
+
+638
+00:56:48,380 --> 00:56:54,590
+بشكل كبير بشكل كبير بشكل كبير بشكل كبلأن هذا المرض
+
+639
+00:56:54,590 --> 00:56:59,730
+أسوء وأكثر مضادًا لأن الـ lymph node ليس مرهقة ولا
+
+640
+00:56:59,730 --> 00:57:01,670
+نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها
+
+641
+00:57:01,670 --> 00:57:02,750
+ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا
+
+642
+00:57:02,750 --> 00:57:03,630
+نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها
+
+643
+00:57:03,630 --> 00:57:04,470
+ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا
+
+644
+00:57:04,470 --> 00:57:06,310
+نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها
+
+645
+00:57:06,310 --> 00:57:08,830
+ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا
+
+646
+00:57:08,830 --> 00:57:11,170
+ولا نشوفها ولا نشوفها ولا نشوفها ولا نشوفها ولا
+
+647
+00:57:11,170 --> 00:57:18,610
+نشوفها ولا نشوفها ولا نشوفها
+
+648
+00:57:19,120 --> 00:57:25,840
+الـ white blood cell بيقلل من ال mass bulk و ال
+
+649
+00:57:25,840 --> 00:57:31,720
+remission غالبا is only short term يعني فترات
+
+650
+00:57:31,720 --> 00:57:36,480
+قصيرة ممكن المريض يخش فيها في ال remission هيري
+
+651
+00:57:36,480 --> 00:57:42,500
+سلو كيميا من الإسم هيري يعني شعر سلو كيميا بتكون
+
+652
+00:57:42,500 --> 00:57:49,390
+خليةموجود في الـ cell membrane تبعها اللي هو الـ
+
+653
+00:57:49,390 --> 00:57:55,280
+Hairy-like structureالمرض بيصيب الاختيارية و ال
+
+654
+00:57:55,280 --> 00:57:58,840
+patient present with marked splenomygaly لكن مافي
+
+655
+00:57:58,840 --> 00:58:02,040
+lymphadenopathy و ال patient have fatigue and
+
+656
+00:58:02,040 --> 00:58:05,340
+malaise لإنه فيه أنيميا فيه pancytopenia ال
+
+657
+00:58:05,340 --> 00:58:09,380
+preference meal بيكون فيه mononuclear lymphocytoid
+
+658
+00:58:09,380 --> 00:58:14,080
+cell with hairy projection on their surface من
+
+659
+00:58:14,080 --> 00:58:19,040
+أسوأ الأمراض بالمناسبة لبوم مرو ييلد إدراي تبتدي
+
+660
+00:58:19,040 --> 00:58:21,600
+تسحب بون مرو و هذه من الصفات characteristic
+
+661
+00:58:21,600 --> 00:58:26,190
+featureبنتيجة تسحب بون مارو Aspiration تطلع
+
+662
+00:58:26,190 --> 00:58:30,230
+الأنبوبة فاضية أو sorry السيرنج فاضي نتيجة إيش
+
+663
+00:58:30,230 --> 00:58:34,670
+نتيجة ال fibrosis اللي صار في ال بون مارو وبالتالي
+
+664
+00:58:34,670 --> 00:58:38,680
+بيسموها dry tap phenomenonSplenectomy and
+
+665
+00:58:38,680 --> 00:58:43,980
+Interferon هو كمو ثيرابيوتك دراجس يعني ماعمله
+
+666
+00:58:43,980 --> 00:58:47,660
+successful is not يعني successful لكن it's not
+
+667
+00:58:47,660 --> 00:58:53,780
+long lasting ماشي هاي اللي هي رسالة والإيمين وفينو
+
+668
+00:58:53,780 --> 00:58:59,680
+تايبنج تبعها يبقى بيسل تايب هي كولة سيديهات عالية
+
+669
+00:59:00,440 --> 00:59:05,740
+والكرمزومة الادنارماليتي مافيش CD5 لكن فيه CD11C
+
+670
+00:59:05,740 --> 00:59:13,820
+CD25 IL-2 ريسبتور كلهم موجودين cytochemistry هذه
+
+671
+00:59:13,820 --> 00:59:17,460
+نقطة مهمة بالمناسبة بيكون عنده حاجة بيسموها trap
+
+672
+00:59:17,460 --> 00:59:21,920
+positive و trap اختصار التارتريت resistant acid
+
+673
+00:59:21,920 --> 00:59:26,400
+phosphataseماشي ايش يعني؟ في حوالي خمسة different
+
+674
+00:59:26,400 --> 00:59:31,260
+acid phosphatase في الجسم نجي بنعمل نسبخ بال acid
+
+675
+00:59:31,260 --> 00:59:35,720
+phosphatase stain عادة
+
+676
+00:59:35,720 --> 00:59:40,800
+it blocks positive ولمّا نضيف ال tartarate to
+
+677
+00:59:40,800 --> 00:59:45,520
+remove the stain في هذا المرض بتضل ال stain will
+
+678
+00:59:45,520 --> 00:59:52,980
+be resist هتضل وعشان هيك بيسموهاTrap Positive فيه
+
+679
+00:59:52,980 --> 00:59:56,500
+Resistance للسترين Pathophysiology، fatigue و easy
+
+680
+00:59:56,500 --> 01:00:01,260
+bruising و repeat infection عادة it's more common
+
+681
+01:00:01,260 --> 01:00:07,560
+than CLL فيه Large Spleen which is not minimal و
+
+682
+01:00:07,560 --> 01:00:13,120
+الرفنود is rare Treatment، بنشيل ال spleen مريح
+
+683
+01:00:13,120 --> 01:00:21,330
+المريض، هذي أول خطوة و خصوصا في Stage 1 و 2وال
+
+684
+01:00:21,330 --> 01:00:24,670
+treatment بتعتمد على اللي هو reaction of spleen
+
+685
+01:00:24,670 --> 01:00:29,130
+removal لو 40% من المرضى require chemotherapy
+
+686
+01:00:29,130 --> 01:00:34,490
+after splenectomy with long with and it will be
+
+687
+01:00:34,490 --> 01:00:41,890
+long term to maintain partial remission بيعتقوا
+
+688
+01:00:41,890 --> 01:00:44,690
+alpha interferon available
+
+689
+01:00:51,110 --> 01:00:57,090
+المشكلة ان هناك انتباد لألفا انترفيروم وبالتالي
+
+690
+01:00:57,090 --> 01:00:59,130
+استعمالته محدودة
+
+691
+01:01:01,000 --> 01:01:07,260
+بهيك بنكون خلصنا المحاضرة ومرّينا على different
+
+692
+01:01:07,260 --> 01:01:11,480
+types of chronic leukemia بما فيها ال myeloid و
+
+693
+01:01:11,480 --> 01:01:19,340
+أكام من نوع من ال lymphoid و شكرا
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..22ed40fe25682052d28d357cd530e9eed7253ed6
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/55EyPNzQ8fc_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2064, "start": 1.94, "end": 20.64, "text": "بسم الله الرحمن الرحيم الصلاة والسلام علي سيد الخلق أجمعين سيدنا محمد الصادق الأمين وبعد نلتقي اليوم في محاضرة جديدة بعنوان chronic leukemia و by definition chronic leukemia", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 31767, 15040, 3660, 16070, 3794, 37440, 25894, 8608, 25708, 33962, 1211, 4587, 5551, 7435, 2304, 3615, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 31767, 18513, 4587, 16247, 2304, 9957, 46599, 22488, 8717, 1211, 2655, 38436, 45595, 20498, 8978, 3714, 5016, 46958, 25720, 10874, 16254, 41891, 45030, 1863, 2407, 7649, 14493, 45970, 29958, 4032, 538, 7123, 14493, 45970, 29958], "avg_logprob": -0.12982536392176852, "compression_ratio": 1.5738636363636365, "no_speech_prob": 1.3649463653564453e-05, "words": [{"start": 1.94, "end": 2.18, "word": "بسم", "probability": 0.841796875}, {"start": 2.18, "end": 2.36, "word": " الله", "probability": 0.96630859375}, {"start": 2.36, "end": 2.7, "word": " الرحمن", "probability": 0.9645182291666666}, {"start": 2.7, "end": 3.12, "word": " الرحيم", "probability": 0.9934895833333334}, {"start": 3.12, "end": 3.52, "word": " الصلاة", "probability": 0.7920735677083334}, {"start": 3.52, "end": 3.94, "word": " والسلام", "probability": 0.9459635416666666}, {"start": 3.94, "end": 4.1, "word": " علي", "probability": 0.489990234375}, {"start": 4.1, "end": 4.48, "word": " سيد", "probability": 0.939697265625}, {"start": 4.48, "end": 4.86, "word": " الخلق", "probability": 0.9265950520833334}, {"start": 4.86, "end": 5.54, "word": " أجمعين", "probability": 0.93037109375}, {"start": 5.54, "end": 6.46, "word": " سيدنا", "probability": 0.9244791666666666}, {"start": 6.46, "end": 6.82, "word": " محمد", "probability": 0.9680989583333334}, {"start": 6.82, "end": 7.32, "word": " الصادق", "probability": 0.9138997395833334}, {"start": 7.32, "end": 7.84, "word": " الأمين", "probability": 0.8771158854166666}, {"start": 7.84, "end": 8.88, 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people", "probability": 0.461669921875}, {"start": 175.32, "end": 177.22, "word": " طبعا", "probability": 0.8729248046875}, {"start": 177.22, "end": 177.48, "word": " ال", "probability": 0.5791015625}, {"start": 177.48, "end": 177.74, "word": " male", "probability": 0.83935546875}, {"start": 177.74, "end": 178.22, "word": " دايما", "probability": 0.8487955729166666}, {"start": 178.22, "end": 179.06, "word": " نصيبهم", "probability": 0.835546875}, {"start": 179.06, "end": 179.6, "word": " أكبر", "probability": 0.8085123697916666}, {"start": 179.6, "end": 180.12, "word": " من", "probability": 0.96923828125}, {"start": 180.12, "end": 180.3, "word": " ال", "probability": 0.8115234375}, {"start": 180.3, "end": 180.7, "word": " female", "probability": 0.91748046875}, {"start": 180.7, "end": 180.92, "word": " ال", "probability": 0.29443359375}, {"start": 180.92, "end": 181.38, "word": " male", "probability": 0.2469482421875}, {"start": 181.38, "end": 181.7, "word": " to", "probability": 0.86572265625}, {"start": 181.7, "end": 182.28, "word": " female", "probability": 0.87255859375}, {"start": 182.28, "end": 182.78, "word": " ratio", "probability": 0.97412109375}, {"start": 182.78, "end": 182.98, "word": " هي", "probability": 0.2030029296875}, {"start": 182.98, "end": 183.16, "word": " one", "probability": 0.46630859375}, {"start": 183.16, "end": 183.38, "word": " point", "probability": 0.9833984375}, {"start": 183.38, "end": 183.7, "word": " four", "probability": 0.94482421875}, {"start": 183.7, "end": 183.86, "word": " to", "probability": 0.74169921875}, {"start": 183.86, "end": 184.16, "word": " one", "probability": 0.95849609375}], "temperature": 1.0}, {"id": 9, "seek": 21331, "start": 185.25, "end": 213.31, "text": "لكن ايضا ممكن تشوف هذه في الأطفال في ال new-age and very old people مش شرط ال middle-aged people لكن بشكل عام ال peak incidence هو لل middle-aged people شوف Philadelphia chromosome طبعا في Philadelphia chromosome بتعرفوا انه هو بيصير في translocation ما بين كرمزوم تسعة و اتنين و عشرين ما بين ال Q arm لهذا و ال Q arm لهذا", "tokens": [1211, 19452, 1975, 1829, 11242, 995, 3714, 43020, 6055, 8592, 38688, 29538, 8978, 16247, 9566, 5172, 6027, 8978, 2423, 777, 12, 609, 293, 588, 1331, 561, 37893, 13412, 2288, 9566, 2423, 2808, 12, 2980, 561, 44381, 4724, 8592, 28820, 6225, 10943, 2423, 10651, 41726, 31439, 24976, 2808, 12, 2980, 561, 13412, 38688, 21205, 42896, 23032, 3555, 3615, 995, 8978, 21205, 42896, 39894, 3615, 28480, 14407, 16472, 3224, 31439, 4724, 1829, 9381, 13546, 8978, 1145, 5842, 399, 19446, 49374, 9122, 2288, 2304, 11622, 20498, 6055, 3794, 27884, 4032, 1975, 2655, 1863, 9957, 4032, 6225, 46309, 9957, 19446, 49374, 2423, 1249, 3726, 46740, 15730, 4032, 2423, 1249, 3726, 46740, 15730], "avg_logprob": -0.29701833768722113, "compression_ratio": 1.726923076923077, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 185.24999999999997, "end": 185.98999999999998, "word": "لكن", "probability": 0.6927490234375}, {"start": 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"probability": 0.57861328125}, {"start": 202.89, "end": 203.57, "word": " chromosome", "probability": 0.97021484375}, {"start": 203.57, "end": 204.77, "word": " بتعرفوا", "probability": 0.9224853515625}, {"start": 204.77, "end": 205.33, "word": " انه", "probability": 0.79638671875}, {"start": 205.33, "end": 205.57, "word": " هو", "probability": 0.4892578125}, {"start": 205.57, "end": 205.95, "word": " بيصير", "probability": 0.9183349609375}, {"start": 205.95, "end": 206.13, "word": " في", "probability": 0.96923828125}, {"start": 206.13, "end": 206.93, "word": " translocation", "probability": 0.762939453125}, {"start": 206.93, "end": 207.11, "word": " ما", "probability": 0.74560546875}, {"start": 207.11, "end": 207.37, "word": " بين", "probability": 0.98046875}, {"start": 207.37, "end": 208.33, "word": " كرمزوم", "probability": 0.806103515625}, {"start": 208.33, "end": 208.69, "word": " تسعة", "probability": 0.8211263020833334}, {"start": 208.69, "end": 208.81, "word": " و", "probability": 0.90771484375}, {"start": 208.81, "end": 209.01, "word": " اتنين", "probability": 0.8546142578125}, {"start": 209.01, "end": 209.11, "word": " و", "probability": 0.978515625}, {"start": 209.11, "end": 209.57, "word": " عشرين", "probability": 0.9365234375}, {"start": 209.57, "end": 210.19, "word": " ما", "probability": 0.86865234375}, {"start": 210.19, "end": 210.37, "word": " بين", "probability": 0.99462890625}, {"start": 210.37, "end": 210.53, "word": " ال", "probability": 0.90966796875}, {"start": 210.53, "end": 210.69, "word": " Q", "probability": 0.54296875}, {"start": 210.69, "end": 211.13, "word": " arm", "probability": 0.482177734375}, {"start": 211.13, "end": 212.13, "word": " لهذا", "probability": 0.80517578125}, {"start": 212.13, "end": 212.27, "word": " و", "probability": 0.779296875}, {"start": 212.27, "end": 212.37, "word": " ال", "probability": 0.309326171875}, {"start": 212.37, "end": 212.55, "word": " Q", "probability": 0.85107421875}, {"start": 212.55, "end": 212.79, "word": " arm", "probability": 0.919921875}, {"start": 212.79, "end": 213.31, "word": " لهذا", "probability": 0.994384765625}], "temperature": 1.0}, {"id": 10, "seek": 22945, "start": 213.91, "end": 229.45, "text": "واللي بيصير إنه بينتقل جزء من الـ Appelsauce بروتو أمكرجين ماشي اللي موجود في كرمزوم رقم 9 إلى ال PCR region اللي موجودة في كرمزوم رقم 22", "tokens": [2407, 6027, 20292, 4724, 1829, 9381, 13546, 36145, 3224, 4724, 9957, 2655, 4587, 1211, 10874, 11622, 38207, 9154, 2423, 39184, 3132, 1625, 1459, 384, 4724, 32887, 2655, 2407, 5551, 2304, 37983, 7435, 9957, 3714, 33599, 1829, 13672, 1829, 3714, 29245, 23328, 8978, 9122, 2288, 2304, 11622, 20498, 12602, 4587, 2304, 1722, 30731, 2423, 44022, 4458, 13672, 1829, 3714, 29245, 23328, 3660, 8978, 9122, 2288, 2304, 11622, 20498, 12602, 4587, 2304, 5853], "avg_logprob": -0.28667536088162, "compression_ratio": 1.4675324675324675, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 213.91, "end": 214.31, "word": "واللي", "probability": 0.6111653645833334}, {"start": 214.31, "end": 214.75, "word": " بيصير", "probability": 0.79681396484375}, {"start": 214.75, "end": 215.05, "word": " إنه", "probability": 0.59063720703125}, {"start": 215.05, "end": 215.59, "word": " بينتقل", "probability": 0.8615234375}, {"start": 215.59, "end": 215.91, "word": " جزء", "probability": 0.9918619791666666}, {"start": 215.91, "end": 216.13, "word": " من", "probability": 0.98583984375}, {"start": 216.13, "end": 216.31, "word": " الـ", "probability": 0.597900390625}, {"start": 216.31, "end": 217.01, "word": " Appelsauce", "probability": 0.30499267578125}, {"start": 217.01, "end": 217.85, "word": " بروتو", "probability": 0.6912841796875}, {"start": 217.85, "end": 218.67, "word": " أمكرجين", "probability": 0.591552734375}, {"start": 218.67, "end": 220.27, "word": " ماشي", "probability": 0.7191569010416666}, {"start": 220.27, "end": 220.81, "word": " اللي", "probability": 0.92626953125}, {"start": 220.81, "end": 221.17, "word": " موجود", "probability": 0.9892578125}, {"start": 221.17, "end": 221.29, "word": " في", "probability": 0.9228515625}, {"start": 221.29, "end": 221.81, "word": " كرمزوم", "probability": 0.82587890625}, {"start": 221.81, "end": 222.17, "word": " رقم", "probability": 0.951171875}, {"start": 222.17, "end": 222.55, "word": " 9", "probability": 0.68310546875}, {"start": 222.55, "end": 223.37, "word": " إلى", "probability": 0.8466796875}, {"start": 223.37, "end": 224.19, "word": " ال", "probability": 0.8642578125}, {"start": 224.19, "end": 224.67, "word": " PCR", "probability": 0.87646484375}, {"start": 224.67, "end": 226.29, "word": " region", "probability": 0.67236328125}, {"start": 226.29, "end": 227.31, "word": " اللي", "probability": 0.9794921875}, {"start": 227.31, "end": 227.75, "word": " موجودة", "probability": 0.987548828125}, {"start": 227.75, "end": 227.89, "word": " في", "probability": 0.97314453125}, {"start": 227.89, "end": 228.43, "word": " كرمزوم", "probability": 0.9916015625}, {"start": 228.43, "end": 228.77, "word": " رقم", "probability": 0.9680989583333334}, {"start": 228.77, "end": 229.45, "word": " 22", "probability": 0.97900390625}], "temperature": 1.0}, {"id": 11, "seek": 24940, "start": 231.32, "end": 249.4, "text": "و أيضا جزء من ال PCR تبع 22 بيروح على رقم 9 و المحصلة new chromosome و ال chromosome ال abnormal ال chromosome هو بيطلع 22 بيكبر كتير و بيسموه Philadelphia chromosome", "tokens": [2407, 36632, 11242, 995, 10874, 11622, 38207, 9154, 2423, 44022, 6055, 3555, 3615, 5853, 4724, 13546, 2407, 5016, 15844, 12602, 4587, 2304, 1722, 4032, 9673, 5016, 9381, 37977, 777, 42896, 4032, 2423, 42896, 2423, 32847, 2423, 42896, 31439, 4724, 1829, 9566, 1211, 3615, 5853, 4724, 1829, 4117, 26890, 9122, 2655, 13546, 4032, 4724, 1829, 38251, 2407, 3224, 21205, 42896], "avg_logprob": -0.35364582637945813, "compression_ratio": 1.4285714285714286, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 231.32, "end": 231.8, "word": "و", 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"word": " المحصلة", "probability": 0.7413330078125}, {"start": 238.9, "end": 239.58, "word": " new", "probability": 0.2305908203125}, {"start": 239.58, "end": 240.42, "word": " chromosome", "probability": 0.9453125}, {"start": 240.42, "end": 241.32, "word": " و", "probability": 0.900390625}, {"start": 241.32, "end": 241.48, "word": " ال", "probability": 0.5}, {"start": 241.48, "end": 242.06, "word": " chromosome", "probability": 0.268798828125}, {"start": 242.06, "end": 242.32, "word": " ال", "probability": 0.424560546875}, {"start": 242.32, "end": 242.68, "word": " abnormal", "probability": 0.48583984375}, {"start": 242.68, "end": 242.92, "word": " ال", "probability": 0.302978515625}, {"start": 242.92, "end": 243.3, "word": " chromosome", "probability": 0.90478515625}, {"start": 243.3, "end": 243.54, "word": " هو", "probability": 0.81982421875}, {"start": 243.54, "end": 244.4, "word": " بيطلع", "probability": 0.8091796875}, {"start": 244.4, "end": 245.1, "word": " 22", "probability": 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abnormal cell بيكون ال alkaline phosphatase function واطيه مش موجود وبالتالي بتكون قدرتها قليل البومبرو is hypercellular", "tokens": [2407, 17082, 6027, 3555, 995, 1975, 1829, 8592, 37495, 22653, 37495, 22653, 47525, 10721, 14407, 4724, 35457, 2407, 11296, 20666, 44220, 533, 19775, 267, 651, 4032, 4724, 44510, 10721, 1975, 22488, 13672, 1829, 31439, 33962, 15040, 25528, 13672, 1829, 3714, 47283, 41891, 8608, 3555, 4587, 11296, 4032, 17082, 6027, 3555, 995, 5296, 33456, 11296, 32847, 2815, 4724, 1829, 30544, 2423, 44220, 533, 19775, 267, 651, 2445, 4032, 41193, 1829, 3224, 37893, 3714, 29245, 23328, 46599, 6027, 2655, 6027, 1829, 39894, 30544, 12174, 3215, 43500, 11296, 12174, 20292, 1211, 29739, 20498, 26890, 2407, 307, 9848, 4164, 1040], "avg_logprob": -0.31556056701030927, "compression_ratio": 1.672811059907834, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 985.09, "end": 985.93, "word": "وغالبا", "probability": 0.6663330078125}, {"start": 985.93, "end": 986.29, 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"word": " ash", "probability": 0.08343505859375}, {"start": 1492.68, "end": 1493.68, "word": " of", "probability": 0.82421875}, {"start": 1493.68, "end": 1494.36, "word": " kinase", "probability": 0.6572265625}, {"start": 1494.36, "end": 1494.88, "word": " enzyme", "probability": 0.93896484375}], "temperature": 1.0}, {"id": 59, "seek": 152497, "start": 1497.67, "end": 1524.97, "text": "البروميوزيز للـCML في الغالب تظهر تجارب كيموثيرابية ممتازة في الفيز الكرونيكي لكن كل ما تقدمنا في الفيزيات التانية بيصير فيها مقاومة كيموثيرابية والموت عادة بيصير بسبب تغيير الأكيو والهمراج", "tokens": [6027, 26890, 20498, 1829, 2407, 11622, 1829, 11622, 24976, 39184, 34, 12683, 8978, 6024, 118, 6027, 3555, 6055, 19913, 3224, 2288, 6055, 7435, 9640, 3555, 9122, 32640, 2407, 12984, 13546, 16758, 10632, 3714, 2304, 2655, 31377, 3660, 8978, 27188, 1829, 11622, 33251, 2288, 11536, 1829, 4117, 1829, 44381, 28242, 19446, 6055, 28543, 2304, 8315, 8978, 27188, 1829, 11622, 1829, 9307, 16712, 7649, 10632, 4724, 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{"start": 1507.55, "end": 1507.55, "word": " ممتازة", "probability": 0.729541015625}, {"start": 1507.55, "end": 1508.31, "word": " في", "probability": 0.75732421875}, {"start": 1508.31, "end": 1508.45, "word": " الفيز", "probability": 0.55267333984375}, {"start": 1508.45, "end": 1508.91, "word": " الكرونيكي", "probability": 0.6725667317708334}, {"start": 1508.91, "end": 1510.51, "word": " لكن", "probability": 0.40625}, {"start": 1510.51, "end": 1510.89, "word": " كل", "probability": 0.91552734375}, {"start": 1510.89, "end": 1511.11, "word": " ما", "probability": 0.75537109375}, {"start": 1511.11, "end": 1512.43, "word": " تقدمنا", "probability": 0.8834228515625}, {"start": 1512.43, "end": 1512.57, "word": " في", "probability": 0.9033203125}, {"start": 1512.57, "end": 1513.19, "word": " الفيزيات", "probability": 0.778466796875}, {"start": 1513.19, "end": 1513.73, "word": " التانية", "probability": 0.9630533854166666}, {"start": 1513.73, "end": 1514.29, "word": " بيصير", "probability": 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infection ونستوقف ناخد استراحة زي ما انتوا شايفين في هذه النوع التاني من ال chronic leukemia هو chronic lymphocytic leukemia", "tokens": [10721, 2407, 11764, 4032, 1863, 14851, 30543, 5172, 8717, 47283, 3215, 44713, 23557, 5016, 3660, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 8978, 29538, 28239, 45367, 16712, 7649, 1829, 9154, 2423, 14493, 45970, 29958, 31439, 14493, 31070, 905, 43658, 45970, 29958], "avg_logprob": -0.29756943384806317, "compression_ratio": 1.3142857142857143, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1526.34, "end": 1526.92, "word": "أو", "probability": 0.6707763671875}, {"start": 1526.92, "end": 1527.64, "word": " infection", "probability": 0.25732421875}, {"start": 1527.64, "end": 1530.74, "word": " ونستوقف", "probability": 0.5662109375}, {"start": 1530.74, "end": 1531.92, "word": " ناخد", "probability": 0.7529296875}, {"start": 1531.92, "end": 1532.7, "word": " استراحة", "probability": 0.974853515625}, {"start": 1532.7, 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marrow في ال lymph nodes في ال spleen ليش بيصير في هذه المواقع؟ هذه خلية mature", "tokens": [1211, 33456, 33962, 1211, 10632, 7251, 20498, 19446, 6055, 9381, 13546, 14442, 39894, 30543, 5172, 16472, 4587, 3794, 10943, 9307, 11296, 14442, 19870, 19446, 39896, 14442, 3714, 19913, 3224, 2288, 11296, 9122, 14442, 31070, 31078, 975, 4032, 2304, 3615, 16472, 3224, 8978, 35647, 7251, 3555, 4587, 7578, 8978, 3224, 31070, 905, 4328, 8211, 4032, 9957, 4724, 1829, 9381, 13546, 2423, 35647, 22807, 13672, 1829, 4724, 1829, 9381, 13546, 8978, 2423, 3390, 8978, 2423, 47739, 8978, 2423, 31070, 13891, 8978, 2423, 4732, 10685, 32239, 8592, 4724, 1829, 9381, 13546, 8978, 29538, 9673, 14407, 4587, 3615, 22807, 29538, 16490, 1211, 10632, 14442], "avg_logprob": -0.2908415723555159, "compression_ratio": 1.7860262008733625, "no_speech_prob": 0.0, "words": [{"start": 1594.96, "end": 1595.4, "word": "لأن", "probability": 0.75732421875}, {"start": 1595.4, "end": 1595.96, "word": " الخلية", "probability": 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{"start": 1799.03, "end": 1799.57, "word": " trisomy", "probability": 0.68585205078125}, {"start": 1799.57, "end": 1800.17, "word": " 12", "probability": 0.765625}, {"start": 1800.17, "end": 1801.37, "word": " و", "probability": 0.73583984375}, {"start": 1801.37, "end": 1801.85, "word": " أيضا", "probability": 0.8748372395833334}, {"start": 1801.85, "end": 1802.01, "word": " في", "probability": 0.8798828125}, {"start": 1802.01, "end": 1802.51, "word": " structure", "probability": 0.58935546875}, {"start": 1802.51, "end": 1803.51, "word": " abnormality", "probability": 0.716064453125}, {"start": 1803.51, "end": 1804.03, "word": " chromosome", "probability": 0.76220703125}, {"start": 1804.03, "end": 1804.67, "word": " 13", "probability": 0.908203125}, {"start": 1804.67, "end": 1804.87, "word": " و", "probability": 0.8759765625}, {"start": 1804.87, "end": 1805.19, "word": " 14", "probability": 0.69189453125}, {"start": 1805.19, "end": 1805.51, "word": " و", "probability": 0.9931640625}, {"start": 1805.51, "end": 1805.97, "word": " 11", "probability": 0.90087890625}, {"start": 1805.97, "end": 1807.45, "word": " و", "probability": 0.91552734375}, {"start": 1807.45, "end": 1808.39, "word": " طبعا", "probability": 0.984130859375}, {"start": 1808.39, "end": 1808.75, "word": " اي", "probability": 0.64892578125}, {"start": 1808.75, "end": 1809.13, "word": " مريض", "probability": 0.9285481770833334}, {"start": 1809.13, "end": 1809.99, "word": " بيكون", "probability": 0.9318033854166666}, {"start": 1809.99, "end": 1810.61, "word": " عنده", "probability": 0.98681640625}, {"start": 1810.61, "end": 1812.29, "word": " كاريوتيبي", "probability": 0.6495768229166666}, {"start": 1812.29, "end": 1813.03, "word": " positive", "probability": 0.55029296875}, {"start": 1813.03, "end": 1813.93, "word": " بي", "probability": 0.6953125}, {"start": 1813.93, "end": 1814.73, "word": " have", "probability": 0.4130859375}, {"start": 1814.73, "end": 1815.85, "word": " bad", "probability": 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"start": 1832.15, "end": 1858.37, "text": "و خمسة و عشرين فيلم لبنية من الحالات لما بتيجي للتشخيص بتكون free of physical symptoms ما بتعاني من أي physical symptoms و بتكتشف بالصدفة و لو ما تكتشف بتكون فيه unexplained absolute unbearable lymphocytosis يبقى هذه أول حاجة بنشوفها", "tokens": [2407, 16490, 2304, 3794, 3660, 4032, 6225, 46309, 9957, 8978, 19528, 5296, 3555, 1863, 10632, 9154, 21542, 6027, 9307, 5296, 15042, 39894, 1829, 7435, 1829, 24976, 2655, 8592, 9778, 1829, 9381, 39894, 30544, 1737, 295, 4001, 8332, 19446, 39894, 3615, 7649, 1829, 9154, 36632, 4001, 8332, 4032, 39894, 4117, 2655, 8592, 5172, 20666, 9381, 3215, 5172, 3660, 4032, 45164, 19446, 6055, 4117, 2655, 8592, 5172, 39894, 30544, 8978, 3224, 11572, 564, 3563, 8236, 517, 26738, 712, 31070, 905, 4328, 8211, 7251, 3555, 4587, 7578, 29538, 5551, 12610, 11331, 26108, 3660, 44945, 8592, 38688, 11296], "avg_logprob": -0.23585527005948517, "compression_ratio": 1.5422222222222222, "no_speech_prob": 5.960464477539063e-08, 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"probability": 0.97900390625}, {"start": 2050.73, "end": 2051.49, "word": " ثم", "probability": 0.94775390625}, {"start": 2051.49, "end": 2051.85, "word": " بيكون", "probability": 0.9287109375}, {"start": 2051.85, "end": 2052.07, "word": " في", "probability": 0.81884765625}, {"start": 2052.07, "end": 2053.13, "word": " autoimmune", "probability": 0.78759765625}, {"start": 2053.13, "end": 2054.01, "word": " hemolysis", "probability": 0.8917236328125}, {"start": 2054.01, "end": 2054.63, "word": " يعني", "probability": 0.892578125}, {"start": 2054.63, "end": 2055.79, "word": " autoimmune", "probability": 0.8896484375}, {"start": 2055.79, "end": 2056.53, "word": " hemolytic", "probability": 0.8817138671875}, {"start": 2056.53, "end": 2057.07, "word": " أنيميا", "probability": 0.8743489583333334}], "temperature": 1.0}, {"id": 81, "seek": 208423, "start": 2058.34, "end": 2084.24, "text": "الـ Platelet و هذه من مضاعفات الـ Autoimmune Hemorrhagic Anemia من مضاعفات هذا النوع من اللوكيميا Platelet بيكون فواطية غالبا بيكون فيه Thrombocytopenic status لو قبلنا blood film هنلاقي 70 ل 99% من الوقت blood cell هي mature lymphocytes و هنلاحظ", "tokens": [6027, 39184, 17461, 15966, 4032, 29538, 9154, 3714, 11242, 45761, 5172, 9307, 2423, 39184, 13738, 49031, 18568, 24362, 71, 559, 299, 1107, 14058, 9154, 3714, 11242, 45761, 5172, 9307, 23758, 28239, 45367, 9154, 13672, 2407, 4117, 32640, 25528, 17461, 15966, 4724, 1829, 30544, 6156, 2407, 41193, 10632, 32771, 6027, 3555, 995, 4724, 1829, 30544, 8978, 3224, 41645, 3548, 905, 4328, 15752, 299, 6558, 45164, 12174, 36150, 8315, 3390, 2007, 8032, 1863, 15040, 38436, 5285, 5296, 11803, 4, 9154, 2423, 30543, 2655, 3390, 2815, 39896, 14442, 31070, 905, 43673, 4032, 8032, 1863, 15040, 5016, 19913], "avg_logprob": -0.28815789724651136, "compression_ratio": 1.482905982905983, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2058.34, "end": 2059.3, "word": "الـ", "probability": 0.5408935546875}, {"start": 2059.3, "end": 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"probability": 0.625}, {"start": 2075.06, "end": 2075.36, "word": " قبلنا", "probability": 0.7444661458333334}, {"start": 2075.36, "end": 2075.6, "word": " blood", "probability": 0.6630859375}, {"start": 2075.6, "end": 2075.94, "word": " film", "probability": 0.84912109375}, {"start": 2075.94, "end": 2076.42, "word": " هنلاقي", "probability": 0.781982421875}, {"start": 2076.42, "end": 2077.02, "word": " 70", "probability": 0.62353515625}, {"start": 2077.02, "end": 2077.18, "word": " ل", "probability": 0.6513671875}, {"start": 2077.18, "end": 2077.98, "word": " 99", "probability": 0.60107421875}, {"start": 2077.98, "end": 2078.64, "word": "%", "probability": 0.8583984375}, {"start": 2078.64, "end": 2079.14, "word": " من", "probability": 0.97705078125}, {"start": 2079.14, "end": 2079.52, "word": " الوقت", "probability": 0.9171549479166666}, {"start": 2079.52, "end": 2079.78, "word": " blood", "probability": 0.6337890625}, {"start": 2079.78, "end": 2080.12, "word": " cell", "probability": 0.84716796875}, {"start": 2080.12, "end": 2080.38, "word": " هي", "probability": 0.6416015625}, {"start": 2080.38, "end": 2080.9, "word": " mature", "probability": 0.92041015625}, {"start": 2080.9, "end": 2082.4, "word": " lymphocytes", "probability": 0.8826497395833334}, {"start": 2082.4, "end": 2083.32, "word": " و", "probability": 0.8623046875}, {"start": 2083.32, "end": 2084.24, "word": " هنلاحظ", "probability": 0.96630859375}], "temperature": 1.0}, {"id": 82, "seek": 211096, "start": 2084.74, "end": 2110.96, "text": "في حاجة بيسموها Smudge Cell او Smear Cell خلايا مفغصة are present ليش؟ لأن الـ lymphocyte is in fragile cell وبالتالي لما تيجي تعمل Smear ماشي عدد كبير من الخلايا ستكون Smudged Immunopheno typically بنلاحظ انه في بي cell marker زي CD19 positive", "tokens": [41185, 11331, 26108, 3660, 4724, 1829, 38251, 2407, 11296, 3915, 16032, 28859, 1975, 2407, 3915, 14881, 28859, 16490, 15040, 25528, 3714, 5172, 17082, 9381, 3660, 366, 1974, 32239, 8592, 22807, 5296, 33456, 2423, 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0.6629638671875}, {"start": 2087.4, "end": 2087.9, "word": " Smear", "probability": 0.6875}, {"start": 2087.9, "end": 2088.44, "word": " Cell", "probability": 0.76025390625}, {"start": 2088.44, "end": 2088.98, "word": " خلايا", "probability": 0.9337565104166666}, {"start": 2088.98, "end": 2089.8, "word": " مفغصة", "probability": 0.8837890625}, {"start": 2089.8, "end": 2090.62, "word": " are", "probability": 0.2271728515625}, {"start": 2090.62, "end": 2091.16, "word": " present", "probability": 0.50146484375}, {"start": 2091.16, "end": 2091.8, "word": " ليش؟", "probability": 0.7027180989583334}, {"start": 2091.8, "end": 2092.06, "word": " لأن", "probability": 0.8662109375}, {"start": 2092.06, "end": 2092.24, "word": " الـ", "probability": 0.434967041015625}, {"start": 2092.24, "end": 2092.78, "word": " lymphocyte", "probability": 0.80419921875}, {"start": 2092.78, "end": 2092.96, "word": " is", "probability": 0.72021484375}, {"start": 2092.96, "end": 2093.26, "word": " in", "probability": 0.53369140625}, {"start": 2093.26, "end": 2093.86, "word": " fragile", "probability": 0.267578125}, {"start": 2093.86, "end": 2094.42, "word": " cell", "probability": 0.78173828125}, {"start": 2094.42, "end": 2095.42, "word": " وبالتالي", "probability": 0.914453125}, {"start": 2095.42, "end": 2095.64, "word": " لما", "probability": 0.8818359375}, {"start": 2095.64, "end": 2095.94, "word": " تيجي", "probability": 0.9580078125}, {"start": 2095.94, "end": 2096.34, "word": " تعمل", "probability": 0.9781901041666666}, {"start": 2096.34, "end": 2096.94, "word": " Smear", "probability": 0.7308349609375}, {"start": 2096.94, "end": 2098.24, "word": " ماشي", "probability": 0.84033203125}, {"start": 2098.24, "end": 2098.8, "word": " عدد", "probability": 0.91845703125}, {"start": 2098.8, "end": 2099.08, "word": " كبير", "probability": 0.9951171875}, {"start": 2099.08, "end": 2099.24, "word": " من", "probability": 0.98828125}, {"start": 2099.24, "end": 2099.9, "word": " الخلايا", "probability": 0.95849609375}, {"start": 2099.9, "end": 2101.52, "word": " ستكون", "probability": 0.4962565104166667}, {"start": 2101.52, "end": 2102.82, "word": " Smudged", "probability": 0.5975748697916666}, {"start": 2102.82, "end": 2104.0, "word": " Immunopheno", "probability": 0.5732177734375}, {"start": 2104.0, "end": 2104.54, "word": " typically", "probability": 0.343994140625}, {"start": 2104.54, "end": 2107.26, "word": " بنلاحظ", "probability": 0.8504638671875}, {"start": 2107.26, "end": 2107.56, "word": " انه", "probability": 0.483642578125}, {"start": 2107.56, "end": 2107.82, "word": " في", "probability": 0.90478515625}, {"start": 2107.82, "end": 2108.36, "word": " بي", "probability": 0.718994140625}, {"start": 2108.36, "end": 2108.6, "word": " cell", "probability": 0.2744140625}, {"start": 2108.6, "end": 2109.18, "word": " marker", "probability": 0.68408203125}, {"start": 2109.18, "end": 2109.58, "word": " زي", "probability": 0.906494140625}, {"start": 2109.58, "end": 2110.32, "word": " CD19", "probability": 0.759033203125}, {"start": 2110.32, "end": 2110.96, "word": " positive", "probability": 0.68017578125}], "temperature": 1.0}, {"id": 83, "seek": 212344, "start": 2112.04, "end": 2123.44, "text": "و أيضا في حاجة بيسموها Light Chain اللي هو Light Chain موجودة في الخلايا", "tokens": [2407, 36632, 11242, 995, 8978, 11331, 26108, 3660, 4724, 1829, 38251, 2407, 11296, 8279, 33252, 13672, 1829, 31439, 8279, 33252, 3714, 29245, 23328, 3660, 8978, 33962, 15040, 25528], "avg_logprob": -0.2403017282485962, "compression_ratio": 1.168421052631579, "no_speech_prob": 0.0, "words": [{"start": 2112.04, "end": 2112.3, "word": "و", "probability": 0.46337890625}, {"start": 2112.3, "end": 2112.76, "word": " أيضا", "probability": 0.69677734375}, {"start": 2112.76, "end": 2112.92, "word": " في", "probability": 0.54296875}, {"start": 2112.92, "end": 2113.3, "word": " حاجة", "probability": 0.9191080729166666}, {"start": 2113.3, "end": 2113.8, "word": " بيسموها", "probability": 0.87724609375}, {"start": 2113.8, "end": 2114.12, "word": " Light", "probability": 0.5419921875}, {"start": 2114.12, "end": 2114.8, "word": " Chain", "probability": 0.56591796875}, {"start": 2114.8, "end": 2116.36, "word": " اللي", "probability": 0.732177734375}, {"start": 2116.36, "end": 2116.88, "word": " هو", "probability": 0.94140625}, {"start": 2116.88, "end": 2120.58, "word": " Light", "probability": 0.53857421875}, {"start": 2120.58, "end": 2121.16, "word": " Chain", "probability": 0.94091796875}, {"start": 2121.16, "end": 2122.0, "word": " موجودة", "probability": 0.9498291015625}, {"start": 2122.0, "end": 2122.74, "word": " في", "probability": 0.953125}, {"start": 2122.74, "end": 2123.44, "word": " الخلايا", "probability": 0.9645182291666666}], "temperature": 1.0}, {"id": 84, "seek": 215289, "start": 2123.95, "end": 2152.89, "text": "تعرفين انه Lighted Chain of Immunoglobulin انت عارفين ان ال B lymphocytes بتصنع antibody و بتصنع ال heavy chain ثم ال lighted chain ثم بتجمعهم مع بعض و تكون antibody ففي الاخر بيكون و هدي ماتش وسل في الاخر بيكون في lighted chain كتيرة لسه ما اتجمعت في الخلية ايضا من ال immunophenotyping بيكون في CD5 positive و CD13 positive", "tokens": [2655, 3615, 28480, 9957, 16472, 3224, 8279, 292, 33252, 295, 17322, 409, 45841, 12176, 259, 16472, 2655, 6225, 9640, 5172, 9957, 16472, 2423, 363, 31070, 905, 43673, 39894, 9381, 1863, 3615, 34507, 4032, 39894, 9381, 1863, 3615, 2423, 4676, 5021, 38637, 2304, 2423, 1442, 292, 5021, 38637, 2304, 39894, 7435, 2304, 3615, 16095, 20449, 45030, 11242, 4032, 6055, 30544, 34507, 6156, 41185, 2423, 47283, 2288, 4724, 1829, 30544, 4032, 8032, 16254, 3714, 9307, 8592, 4032, 3794, 1211, 8978, 2423, 47283, 2288, 4724, 1829, 30544, 8978, 1442, 292, 5021, 9122, 2655, 48923, 5296, 3794, 3224, 19446, 1975, 2655, 7435, 2304, 34268, 8978, 33962, 1211, 10632, 1975, 1829, 11242, 995, 9154, 2423, 13154, 404, 2932, 6737, 3381, 4724, 1829, 30544, 8978, 6743, 20, 3353, 4032, 6743, 7668, 3353], 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كيش", "probability": 0.6475423177083334}, {"start": 2254.57, "end": 2255.15, "word": " بتعمل", "probability": 0.7764485677083334}, {"start": 2255.15, "end": 2255.53, "word": " عشان", "probability": 0.966796875}, {"start": 2255.53, "end": 2256.09, "word": " اؤكد", "probability": 0.9078369140625}, {"start": 2256.09, "end": 2256.31, "word": " هذا", "probability": 0.93994140625}, {"start": 2256.31, "end": 2257.01, "word": " التشخيص", "probability": 0.9447265625}], "temperature": 1.0}, {"id": 89, "seek": 228464, "start": 2257.5, "end": 2284.64, "text": "أولا نمرة واحد بدي أدور على ال expression of either كعبة or لمدة lighted chain هذه أنواع ال lighted chain of immunoglobulin وين on cell surface membrane نمرة اتنين طبعا هذا الكلام موجود في ال B-lymphocyte مش موجود في ال D-lymphocyte نمرة اتنين presence of unique idiotypic specificity", "tokens": [10721, 12610, 995, 8717, 2304, 25720, 36764, 24401, 4724, 16254, 5551, 3215, 13063, 15844, 2423, 6114, 295, 2139, 9122, 3615, 49401, 420, 32767, 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الفاب وجزء بيسموه ال Fc الفاب هو مناطق ارتباط الانتيبادي بالانتيجن وكل انتيبادي موجود في الجسم", "tokens": [266, 264, 13154, 45841, 12176, 259, 7126, 538, 12855, 43, 5438, 1975, 1829, 8592, 37495, 22653, 1975, 1829, 16254, 35473, 1829, 21292, 4117, 1829, 2685, 507, 37495, 22653, 16472, 2423, 7649, 31371, 3555, 995, 16254, 7251, 2655, 30544, 9154, 10874, 11622, 19986, 9957, 10874, 11622, 38207, 4724, 1829, 38251, 2407, 3224, 27188, 16758, 49610, 11622, 38207, 4724, 1829, 38251, 2407, 3224, 2423, 479, 66, 27188, 16758, 31439, 9154, 41193, 4587, 1975, 43500, 3555, 41193, 2423, 7649, 31371, 3555, 995, 16254, 20666, 7649, 31371, 7435, 1863, 4032, 28820, 16472, 31371, 3555, 995, 16254, 3714, 29245, 23328, 8978, 25724, 38251], "avg_logprob": -0.2403724744464412, "compression_ratio": 1.74, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2285.97, "end": 2286.39, "word": "on", "probability": 0.06756591796875}, {"start": 2286.39, "end": 2286.53, "word": " the", "probability": 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مختلفة طب لما بيصير فيها hypersplenism، شو يعني؟ خزن خلايا زيدها لجوه، فقل عددها في ال peripheral blood فصار في أنهينيا، ثم بوسيطوبينيا، أنيوتروبيليو", "tokens": [41361, 14407, 4724, 1829, 9778, 11622, 1863, 9122, 2304, 1829, 9307, 9122, 3555, 48923, 9154, 33962, 15040, 25528, 5296, 28814, 1863, 36764, 24401, 4032, 19913, 16373, 5172, 2423, 39184, 50, 781, 268, 31439, 16712, 9778, 11622, 9957, 9122, 2304, 7649, 20666, 28814, 11242, 31845, 3660, 32239, 3224, 13672, 1829, 31439, 18863, 42213, 9673, 8315, 3615, 1829, 34051, 2423, 2407, 19913, 33911, 3660, 9673, 8315, 3615, 10632, 46740, 12399, 13672, 1829, 16490, 2304, 3794, 12399, 8608, 2655, 4032, 19913, 16373, 5172, 3714, 46456, 46538, 3660, 23032, 3555, 5296, 15042, 4724, 1829, 9381, 13546, 8978, 11296, 9848, 46535, 268, 1434, 12399, 13412, 2407, 37495, 22653, 22807, 16490, 11622, 1863, 16490, 15040, 25528, 30767, 25708, 11296, 5296, 7435, 2407, 3224, 12399, 6156, 4587, 1211, 6225, 3215, 3215, 11296, 8978, 2423, 40235, 3390, 6156, 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"probability": 0.9384765625}, {"start": 2706.73, "end": 2707.89, "word": " او", "probability": 0.7281494140625}, {"start": 2707.89, "end": 2708.79, "word": " Antibody", "probability": 0.9402669270833334}, {"start": 2708.79, "end": 2709.39, "word": " against", "probability": 0.88232421875}, {"start": 2709.39, "end": 2710.69, "word": " his", "probability": 0.912109375}, {"start": 2710.69, "end": 2711.77, "word": " Blatelet", "probability": 0.4525553385416667}, {"start": 2711.77, "end": 2712.57, "word": " بصير", "probability": 0.7992350260416666}, {"start": 2712.57, "end": 2712.75, "word": " فيه", "probability": 0.78271484375}, {"start": 2712.75, "end": 2712.91, "word": " حد", "probability": 0.925537109375}, {"start": 2712.91, "end": 2713.37, "word": " بيسموها", "probability": 0.8123046875}, {"start": 2713.37, "end": 2714.07, "word": " Idiopathic", "probability": 0.7339680989583334}, {"start": 2714.07, "end": 2715.09, "word": " Thrombocytopenic", "probability": 0.9073893229166666}, {"start": 2715.09, "end": 2716.25, "word": " Pairup", "probability": 0.3413899739583333}, {"start": 2716.25, "end": 2716.99, "word": " او", "probability": 0.94287109375}, {"start": 2716.99, "end": 2718.81, "word": " Antibody", "probability": 0.9114583333333334}, {"start": 2718.81, "end": 2719.11, "word": " ضد", "probability": 0.9521484375}, {"start": 2719.11, "end": 2719.71, "word": " النيتروفيل", "probability": 0.6594645182291666}, {"start": 2719.71, "end": 2720.37, "word": " تبعته", "probability": 0.8436279296875}, {"start": 2720.37, "end": 2721.49, "word": " وبصير", "probability": 0.8181966145833334}, {"start": 2721.49, "end": 2721.89, "word": " فيه", "probability": 0.964111328125}, {"start": 2721.89, "end": 2722.47, "word": " Immune", "probability": 0.7509765625}, {"start": 2722.47, "end": 2724.39, "word": " Neutropenia", "probability": 0.87568359375}], "temperature": 1.0}, {"id": 107, "seek": 275073, "start": 2726.59, "end": 2750.73, "text": "وهي المراحل المرضية لهذا المرض قالوا الـ staging is very important for the prognosis and treatment بهم جدا يعرفوا في أي مرحلة من المراحل لأي مرحلة وصل للمريض عند التشخيص في هذا المرض وبالتالي اعتمدوا two staging system واحد اسمه Rhea والتاني اسمه pilot", "tokens": [2407, 3224, 1829, 9673, 23557, 5016, 1211, 9673, 43042, 10632, 46740, 15730, 9673, 43042, 12174, 6027, 14407, 2423, 39184, 41085, 307, 588, 1021, 337, 264, 447, 4568, 8211, 293, 5032, 4724, 16095, 10874, 28259, 37495, 28480, 14407, 8978, 36632, 3714, 2288, 5016, 37977, 9154, 9673, 23557, 5016, 1211, 5296, 10721, 1829, 3714, 2288, 5016, 37977, 4032, 36520, 5296, 19528, 16572, 11242, 43242, 16712, 8592, 9778, 1829, 9381, 8978, 23758, 9673, 43042, 46599, 6027, 2655, 6027, 1829, 1975, 34268, 2304, 3215, 14407, 732, 41085, 1185, 36764, 24401, 24525, 2304, 3224, 497, 27799, 16070, 2655, 7649, 1829, 24525, 2304, 3224, 9691], "avg_logprob": -0.21499999657273292, "compression_ratio": 1.6973684210526316, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 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two", "probability": 0.447998046875}, {"start": 2748.01, "end": 2748.43, "word": " staging", "probability": 0.9443359375}, {"start": 2748.43, "end": 2748.95, "word": " system", "probability": 0.5595703125}, {"start": 2748.95, "end": 2749.21, "word": " واحد", "probability": 0.974609375}, {"start": 2749.21, "end": 2749.45, "word": " اسمه", "probability": 0.9669596354166666}, {"start": 2749.45, "end": 2749.69, "word": " Rhea", "probability": 0.29986572265625}, {"start": 2749.69, "end": 2750.09, "word": " والتاني", "probability": 0.8179931640625}, {"start": 2750.09, "end": 2750.37, "word": " اسمه", "probability": 0.9248046875}, {"start": 2750.37, "end": 2750.73, "word": " pilot", "probability": 0.2354736328125}], "temperature": 1.0}, {"id": 108, "seek": 278099, "start": 2751.47, "end": 2780.99, "text": "والمرض يمر في خمس مراحل مختلفة مرحلة Zero فقط المريض بيجي نابل lymphocytosis بيكون أكتر من 150 ألف نمرة واحد بيكون بيجي المريض ب Stage Zero يعني lymphocytosis وفي lymph node enlargement بيكون في مرحلة واحد مرحلة Stage Two", "tokens": [2407, 6027, 29973, 11242, 7251, 29973, 8978, 16490, 2304, 3794, 3714, 23557, 5016, 1211, 3714, 46456, 46538, 3660, 3714, 2288, 5016, 37977, 17182, 6156, 47432, 9673, 16572, 11242, 4724, 1829, 7435, 1829, 8717, 16758, 1211, 31070, 905, 4328, 8211, 4724, 1829, 30544, 5551, 4117, 2655, 2288, 9154, 8451, 5551, 46538, 8717, 2304, 25720, 36764, 24401, 4724, 1829, 30544, 4724, 1829, 7435, 1829, 9673, 16572, 11242, 4724, 25907, 17182, 37495, 22653, 31070, 905, 4328, 8211, 4032, 41185, 31070, 9984, 31976, 48122, 4724, 1829, 30544, 8978, 3714, 2288, 5016, 37977, 36764, 24401, 3714, 2288, 5016, 37977, 25907, 4453], "avg_logprob": -0.2653028350515464, "compression_ratio": 1.7128205128205127, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2751.47, "end": 2752.25, "word": "والمرض", "probability": 0.369873046875}, {"start": 2752.25, "end": 2754.77, "word": " يمر", "probability": 0.76220703125}, {"start": 2754.77, "end": 2754.95, "word": 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2772.23, "end": 2773.05, "word": " يعني", "probability": 0.7587890625}, {"start": 2773.05, "end": 2774.09, "word": " lymphocytosis", "probability": 0.9205322265625}, {"start": 2774.09, "end": 2774.75, "word": " وفي", "probability": 0.88916015625}, {"start": 2774.75, "end": 2775.07, "word": " lymph", "probability": 0.64501953125}, {"start": 2775.07, "end": 2776.33, "word": " node", "probability": 0.66943359375}, {"start": 2776.33, "end": 2776.99, "word": " enlargement", "probability": 0.96435546875}, {"start": 2776.99, "end": 2777.33, "word": " بيكون", "probability": 0.9012044270833334}, {"start": 2777.33, "end": 2777.49, "word": " في", "probability": 0.88037109375}, {"start": 2777.49, "end": 2777.99, "word": " مرحلة", "probability": 0.97607421875}, {"start": 2777.99, "end": 2779.47, "word": " واحد", "probability": 0.967529296875}, {"start": 2779.47, "end": 2780.31, "word": " مرحلة", "probability": 0.945068359375}, {"start": 2780.31, "end": 2780.69, "word": " Stage", "probability": 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"text": "الـ Leukomagenesis طبعا في نفس الكرمزومة الـ abnormality اللى توا حاكين عليها 11 و 14 و 13 ماشي حالي 50 ل 75% من ال translocation بتوصيب ال BCL1 Oncogen", "tokens": [6027, 39184, 1456, 2034, 298, 4698, 9374, 23032, 3555, 3615, 995, 8978, 8717, 36178, 33251, 2288, 2304, 11622, 20498, 3660, 2423, 39184, 47104, 1860, 13672, 7578, 6055, 14407, 11331, 995, 4117, 9957, 25894, 11296, 2975, 4032, 3499, 4032, 3705, 3714, 33599, 1829, 11331, 6027, 1829, 2625, 5296, 9562, 4, 9154, 2423, 1145, 5842, 399, 39894, 2407, 9381, 1829, 3555, 2423, 14359, 43, 16, 1282, 66, 8799], "avg_logprob": -0.37943098260395564, "compression_ratio": 1.2203389830508475, "no_speech_prob": 8.940696716308594e-07, "words": [{"start": 3173.26, "end": 3173.98, "word": "الـ", "probability": 0.417236328125}, {"start": 3173.98, "end": 3174.88, "word": " Leukomagenesis", "probability": 0.619091796875}, {"start": 3174.88, "end": 3175.5, "word": " طبعا", "probability": 0.83038330078125}, {"start": 3175.5, "end": 3175.72, "word": " في", "probability": 0.77587890625}, {"start": 3175.72, "end": 3176.04, "word": " نفس", "probability": 0.972412109375}, {"start": 3176.04, "end": 3176.7, "word": " الكرمزومة", "probability": 0.6824951171875}, {"start": 3176.7, "end": 3176.76, "word": " الـ", "probability": 0.656005859375}, {"start": 3176.76, "end": 3177.3, "word": " abnormality", "probability": 0.82275390625}, {"start": 3177.3, "end": 3177.48, "word": " اللى", "probability": 0.6456298828125}, {"start": 3177.48, "end": 3177.66, "word": " توا", "probability": 0.37646484375}, {"start": 3177.66, "end": 3177.94, "word": " حاكين", "probability": 0.8265380859375}, {"start": 3177.94, "end": 3178.44, "word": " عليها", "probability": 0.984619140625}, {"start": 3178.44, "end": 3179.7, "word": " 11", "probability": 0.580078125}, {"start": 3179.7, "end": 3179.96, "word": " و", "probability": 0.67626953125}, {"start": 3179.96, "end": 3180.34, "word": " 14", "probability": 0.55712890625}, {"start": 3180.34, "end": 3180.68, "word": " و", "probability": 0.9130859375}, {"start": 3180.68, "end": 3181.08, "word": " 13", "probability": 0.83056640625}, {"start": 3181.08, "end": 3182.48, "word": " ماشي", "probability": 0.85498046875}, {"start": 3182.48, "end": 3183.14, "word": " حالي", "probability": 0.5006917317708334}, {"start": 3183.14, "end": 3183.54, "word": " 50", "probability": 0.8203125}, {"start": 3183.54, "end": 3183.8, "word": " ل", "probability": 0.7236328125}, {"start": 3183.8, "end": 3184.76, "word": " 75", "probability": 0.66552734375}, {"start": 3184.76, "end": 3185.42, "word": "%", "probability": 0.734375}, {"start": 3185.42, "end": 3185.72, "word": " من", "probability": 0.9814453125}, {"start": 3185.72, "end": 3185.88, "word": " ال", "probability": 0.5712890625}, {"start": 3185.88, "end": 3186.72, "word": " translocation", "probability": 0.6708170572916666}, {"start": 3186.72, "end": 3187.76, "word": " بتوصيب", "probability": 0.9494140625}, {"start": 3187.76, "end": 3187.88, "word": " ال", "probability": 0.85546875}, {"start": 3187.88, "end": 3189.48, "word": " BCL1", "probability": 0.763671875}, {"start": 3189.48, "end": 3190.26, "word": " Oncogen", "probability": 0.6746012369791666}], "temperature": 1.0}, {"id": 124, "seek": 320704, "start": 3190.94, "end": 3207.04, "text": "مشي واحدة هو مكان تكوين ال heavy chain gene اللي مسؤول عن ال heavy chain immunoglobulin product كمان في ال", "tokens": [2304, 8592, 1829, 36764, 24401, 3660, 31439, 3714, 41361, 6055, 4117, 2407, 9957, 2423, 4676, 5021, 12186, 13672, 1829, 47524, 33604, 12610, 18871, 2423, 4676, 5021, 13154, 45841, 12176, 259, 1674, 9122, 2304, 7649, 8978, 2423], "avg_logprob": -0.26583614220490326, "compression_ratio": 1.2131147540983607, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 3190.94, "end": 3191.48, "word": "مشي", "probability": 0.5030924479166666}, {"start": 3191.48, "end": 3191.78, "word": " واحدة", "probability": 0.8504231770833334}, {"start": 3191.78, "end": 3191.98, "word": " هو", "probability": 0.8125}, {"start": 3191.98, "end": 3192.52, "word": " مكان", "probability": 0.955078125}, {"start": 3192.52, "end": 3193.18, "word": " تكوين", "probability": 0.9342041015625}, {"start": 3193.18, "end": 3193.4, "word": " ال", "probability": 0.74658203125}, {"start": 3193.4, "end": 3193.58, "word": " heavy", "probability": 0.40625}, {"start": 3193.58, "end": 3194.12, "word": " chain", "probability": 0.489013671875}, {"start": 3194.12, "end": 3194.86, "word": " gene", "probability": 0.47607421875}, {"start": 3194.86, "end": 3196.2, "word": " اللي", "probability": 0.764404296875}, {"start": 3196.2, "end": 3196.66, "word": " مسؤول", "probability": 0.8095703125}, {"start": 3196.66, "end": 3197.1, "word": " عن", "probability": 0.98876953125}, {"start": 3197.1, "end": 3198.06, "word": " ال", "probability": 0.87890625}, {"start": 3198.06, "end": 3198.66, "word": " heavy", "probability": 0.7666015625}, {"start": 3198.66, "end": 3199.48, "word": " chain", "probability": 0.7900390625}, {"start": 3199.48, "end": 3200.84, "word": " immunoglobulin", "probability": 0.9771728515625}, {"start": 3200.84, "end": 3204.56, "word": " product", "probability": 0.9462890625}, {"start": 3204.56, "end": 3206.12, "word": " كمان", "probability": 0.8551432291666666}, {"start": 3206.12, "end": 3206.5, "word": " في", "probability": 0.97021484375}, {"start": 3206.5, "end": 3207.04, "word": " ال", "probability": 0.93017578125}], "temperature": 1.0}, {"id": 125, "seek": 323524, "start": 3207.8, "end": 3235.24, "text": "أو كرمزوم 14Q332 هذه برضه منطقة بيصير فيها expression ل بيه lymphocyte growth factor لما بتنضرب يعني بيبطل فيه بيه lymphocyte growth factor في other cytogenetic abnormality زي ما قلت لكوا في Trisomy 12 في اللي هو rearrangement of 3B 11B and 12B بالمقارنة", "tokens": [10721, 2407, 9122, 2288, 2304, 11622, 20498, 3499, 48, 10191, 17, 29538, 4724, 43042, 3224, 9154, 9566, 28671, 4724, 1829, 9381, 13546, 8978, 11296, 6114, 5296, 4724, 1829, 3224, 31070, 31078, 975, 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منطقة", "probability": 0.9205729166666666}, {"start": 3211.9, "end": 3212.28, "word": " بيصير", "probability": 0.8929443359375}, {"start": 3212.28, "end": 3212.7, "word": " فيها", "probability": 0.925048828125}, {"start": 3212.7, "end": 3213.58, "word": " expression", "probability": 0.55322265625}, {"start": 3213.58, "end": 3213.84, "word": " ل", "probability": 0.876953125}, {"start": 3213.84, "end": 3215.18, "word": " بيه", "probability": 0.4498494466145833}, {"start": 3215.18, "end": 3216.1, "word": " lymphocyte", "probability": 0.7913411458333334}, {"start": 3216.1, "end": 3216.36, "word": " growth", "probability": 0.92333984375}, {"start": 3216.36, "end": 3216.94, "word": " factor", "probability": 0.8662109375}, {"start": 3216.94, "end": 3217.54, "word": " لما", "probability": 0.77392578125}, {"start": 3217.54, "end": 3218.08, "word": " بتنضرب", "probability": 0.65643310546875}, {"start": 3218.08, "end": 3218.42, "word": " يعني", "probability": 0.917724609375}, {"start": 3218.42, "end": 3219.4, "word": " بيبطل", "probability": 0.87333984375}, {"start": 3219.4, "end": 3219.66, "word": " فيه", "probability": 0.7861328125}, {"start": 3219.66, "end": 3219.82, "word": " بيه", "probability": 0.8780924479166666}, {"start": 3219.82, "end": 3220.38, "word": " lymphocyte", "probability": 0.92138671875}, {"start": 3220.38, "end": 3220.6, "word": " growth", "probability": 0.95263671875}, {"start": 3220.6, "end": 3221.2, "word": " factor", "probability": 0.90380859375}, {"start": 3221.2, "end": 3222.46, "word": " في", "probability": 0.8544921875}, {"start": 3222.46, "end": 3222.92, "word": " other", "probability": 0.3701171875}, {"start": 3222.92, "end": 3223.8, "word": " cytogenetic", "probability": 0.7438151041666666}, {"start": 3223.8, "end": 3224.44, "word": " abnormality", "probability": 0.746826171875}, {"start": 3224.44, "end": 3224.68, "word": " زي", "probability": 0.6136474609375}, {"start": 3224.68, "end": 3224.76, "word": " ما", "probability": 0.59814453125}, {"start": 3224.76, "end": 3224.94, "word": " قلت", "probability": 0.7273763020833334}, {"start": 3224.94, "end": 3225.26, "word": " لكوا", "probability": 0.8072916666666666}, {"start": 3225.26, "end": 3225.52, "word": " في", "probability": 0.96826171875}, {"start": 3225.52, "end": 3227.18, "word": " Trisomy", "probability": 0.6770426432291666}, {"start": 3227.18, "end": 3227.86, "word": " 12", "probability": 0.8076171875}, {"start": 3227.86, "end": 3228.78, "word": " في", "probability": 0.873046875}, {"start": 3228.78, "end": 3229.26, "word": " اللي", "probability": 0.886962890625}, {"start": 3229.26, "end": 3229.48, "word": " هو", "probability": 0.97119140625}, {"start": 3229.48, "end": 3230.3, "word": " rearrangement", "probability": 0.796142578125}, {"start": 3230.3, "end": 3230.64, "word": " of", "probability": 0.89501953125}, {"start": 3230.64, "end": 3231.36, "word": " 3B", "probability": 0.6370849609375}, {"start": 3231.36, "end": 3232.6, "word": " 11B", "probability": 0.672607421875}, {"start": 3232.6, "end": 3232.88, "word": " and", "probability": 0.302490234375}, {"start": 3232.88, "end": 3233.58, "word": " 12B", "probability": 0.947509765625}, {"start": 3233.58, "end": 3235.24, "word": " بالمقارنة", "probability": 0.9662272135416666}], "temperature": 1.0}, {"id": 126, "seek": 325258, "start": 3235.78, "end": 3252.58, "text": "مابين الـ TBLL و الـ PBLL TBLL كرمزوم الأبنرمالتي بنشوفها في الـ 14Q1111 في منطقة مسئولة عن الـ T cell receptor Alpha chain gene", "tokens": [2304, 16758, 9957, 2423, 39184, 314, 17624, 43, 4032, 2423, 39184, 430, 17624, 43, 314, 17624, 43, 9122, 2288, 2304, 11622, 20498, 16247, 3555, 1863, 2288, 2304, 6027, 31371, 44945, 8592, 38688, 11296, 8978, 2423, 39184, 3499, 48, 5348, 5348, 8978, 9154, 9566, 28671, 47524, 19986, 12610, 3660, 18871, 2423, 39184, 314, 2815, 32264, 20588, 5021, 12186], "avg_logprob": -0.39924568965517243, "compression_ratio": 1.272108843537415, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 3235.78, "end": 3236.36, "word": "مابين", "probability": 0.59564208984375}, {"start": 3236.36, "end": 3236.6, "word": " الـ", "probability": 0.5994873046875}, {"start": 3236.6, "end": 3237.52, "word": " TBLL", "probability": 0.6279296875}, {"start": 3237.52, "end": 3237.66, "word": " و", "probability": 0.6865234375}, {"start": 3237.66, "end": 3237.82, "word": " الـ", "probability": 0.400146484375}, {"start": 3237.82, "end": 3238.88, "word": " PBLL", "probability": 0.7455240885416666}, {"start": 3238.88, "end": 3240.48, "word": " TBLL", "probability": 0.6888020833333334}, {"start": 3240.48, "end": 3241.14, "word": " كرمزوم", "probability": 0.6693359375}, {"start": 3241.14, "end": 3242.08, "word": " الأبنرمالتي", "probability": 0.6518205915178571}, {"start": 3242.08, "end": 3242.7, "word": " بنشوفها", "probability": 0.82550048828125}, {"start": 3242.7, "end": 3242.8, "word": " في", "probability": 0.794921875}, {"start": 3242.8, "end": 3242.98, "word": " الـ", "probability": 0.74560546875}, {"start": 3242.98, "end": 3244.6, "word": " 14Q1111", "probability": 0.764892578125}, {"start": 3244.6, "end": 3247.42, "word": " في", "probability": 0.85205078125}, {"start": 3247.42, "end": 3247.98, "word": " منطقة", "probability": 0.98046875}, {"start": 3247.98, "end": 3249.1, "word": " مسئولة", "probability": 0.88623046875}, {"start": 3249.1, "end": 3249.28, "word": " عن", "probability": 0.9951171875}, {"start": 3249.28, "end": 3249.46, "word": " الـ", "probability": 0.829345703125}, {"start": 3249.46, "end": 3249.62, "word": " T", "probability": 0.8828125}, {"start": 3249.62, "end": 3249.9, "word": " cell", "probability": 0.56640625}, {"start": 3249.9, "end": 3250.52, "word": " receptor", "probability": 0.8701171875}, {"start": 3250.52, "end": 3251.8, "word": " Alpha", "probability": 0.64599609375}, {"start": 3251.8, "end": 3252.28, "word": " chain", "probability": 0.296875}, {"start": 3252.28, "end": 3252.58, "word": " gene", "probability": 0.98095703125}], "temperature": 1.0}, {"id": 127, "seek": 327256, "start": 3254.34, "end": 3272.56, "text": "و هذه الـ Abnormality طبعاً هي هذه ال frequency of أكتر من خمسين فمية من حاليات ال TBLL recognition وجود أكتر من خمس و خمسين فمية فمه Pro lymphocytes في ال peripheral blood at presentation", "tokens": [2407, 29538, 2423, 39184, 2847, 13403, 1860, 23032, 3555, 3615, 995, 14111, 39896, 29538, 2423, 7893, 295, 5551, 4117, 2655, 2288, 9154, 16490, 2304, 3794, 9957, 6156, 2304, 10632, 9154, 11331, 6027, 1829, 9307, 2423, 29711, 24010, 11150, 49610, 23328, 5551, 4117, 2655, 2288, 9154, 16490, 2304, 3794, 4032, 16490, 2304, 3794, 9957, 6156, 2304, 10632, 6156, 2304, 3224, 1705, 31070, 905, 43673, 8978, 2423, 40235, 3390, 412, 5860], "avg_logprob": -0.3294642806053162, "compression_ratio": 1.4316939890710383, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3254.34, "end": 3254.6, "word": "و", "probability": 0.5078125}, {"start": 3254.6, "end": 3254.9, "word": " هذه", "probability": 0.42919921875}, {"start": 3254.9, "end": 3255.04, "word": " الـ", "probability": 0.5711669921875}, {"start": 3255.04, "end": 3255.66, "word": " Abnormality", "probability": 0.7568359375}, {"start": 3255.66, "end": 3256.04, "word": " طبعاً", "probability": 0.848681640625}, {"start": 3256.04, "end": 3256.16, "word": " هي", "probability": 0.38330078125}, {"start": 3256.16, "end": 3256.32, "word": " هذه", "probability": 0.354736328125}, {"start": 3256.32, "end": 3256.36, "word": " ال", "probability": 0.822265625}, {"start": 3256.36, "end": 3256.8, "word": " frequency", "probability": 0.68701171875}, {"start": 3256.8, "end": 3257.18, "word": " of", "probability": 0.256591796875}, {"start": 3257.18, "end": 3258.02, "word": " أكتر", "probability": 0.889404296875}, {"start": 3258.02, "end": 3258.1, "word": " من", "probability": 0.98876953125}, {"start": 3258.1, "end": 3258.5, "word": " خمسين", "probability": 0.8775634765625}, {"start": 3258.5, "end": 3258.96, "word": " فمية", "probability": 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condensed chromatin material prominent nucleolus و هذا هي شكل ال pro lymphocytic leukemia طبعا ال pro lymphocytic leukemia بتتميز بوجود raised white blood cell", "tokens": [2407, 23032, 3555, 3615, 995, 29538, 16490, 1211, 10632, 6225, 3555, 9640, 3660, 18871, 16490, 1211, 10632, 5551, 4117, 26890, 4833, 813, 31070, 905, 43673, 4032, 23391, 295, 3185, 19337, 7743, 76, 4032, 4724, 1829, 30544, 8978, 11296, 36398, 16209, 22685, 2527, 17034, 14962, 401, 301, 4032, 23758, 39896, 13412, 28820, 2423, 447, 31070, 905, 43658, 45970, 29958, 23032, 3555, 3615, 995, 2423, 447, 31070, 905, 43658, 45970, 29958, 39894, 39237, 1829, 11622, 4724, 29245, 23328, 6005, 2418, 3390, 2815], "avg_logprob": -0.17717978100717804, "compression_ratio": 1.5046728971962617, "no_speech_prob": 0.0, "words": [{"start": 3273.44, "end": 3273.7, "word": "و", "probability": 0.5048828125}, {"start": 3273.7, "end": 3274.0, "word": " طبعا", "probability": 0.82293701171875}, {"start": 3274.0, "end": 3274.18, "word": " هذه", 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minimal و الرفنود is rare Treatment، بنشيل ال spleen مريح المريض، هذي أول خطوة و خصوصا في Stage 1 و 2", "tokens": [51, 4007, 46326, 8978, 3224, 45647, 24976, 14851, 2288, 9957, 21914, 5317, 749, 46457, 12399, 20574, 4032, 1858, 25267, 3436, 4032, 7149, 11764, 6225, 18513, 3660, 309, 311, 544, 2689, 813, 12855, 43, 8978, 3224, 33092, 19788, 10685, 597, 307, 406, 13206, 4032, 2423, 28480, 1863, 23328, 307, 5892, 20298, 518, 12399, 44945, 8592, 26895, 2423, 4732, 10685, 3714, 16572, 5016, 9673, 16572, 11242, 12399, 8032, 8848, 1829, 5551, 12610, 16490, 9566, 2407, 3660, 4032, 16490, 9381, 2407, 9381, 995, 8978, 25907, 502, 4032, 568], "avg_logprob": -0.42405524226122127, "compression_ratio": 1.3, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 3590.26, "end": 3590.88, "word": "Trap", "probability": 0.29052734375}, {"start": 3590.88, "end": 3591.7, "word": " Positive", "probability": 0.38818359375}, {"start": 3591.7, "end": 3592.98, "word": " فيه", "probability": 0.4283447265625}, {"start": 3592.98, "end": 3593.52, "word": " Resistance", "probability": 0.423583984375}, {"start": 3593.52, "end": 3594.54, "word": " للسترين", "probability": 0.5491943359375}, {"start": 3594.54, "end": 3595.82, "word": " Pathophysiology،", "probability": 0.71552734375}, {"start": 3595.82, "end": 3596.14, "word": " fatigue", "probability": 0.475341796875}, {"start": 3596.14, "end": 3596.34, "word": " و", "probability": 0.7890625}, {"start": 3596.34, "end": 3596.5, "word": " easy", "probability": 0.67724609375}, {"start": 3596.5, "end": 3596.94, "word": " bruising", "probability": 0.898193359375}, {"start": 3596.94, "end": 3597.12, "word": " و", "probability": 0.89794921875}, {"start": 3597.12, "end": 3597.34, "word": " repeat", "probability": 0.39599609375}, {"start": 3597.34, "end": 3597.94, "word": " infection", "probability": 0.8798828125}, {"start": 3597.94, "end": 3600.18, "word": " عادة", "probability": 0.9772135416666666}, {"start": 3600.18, "end": 3600.62, "word": " it's", "probability": 0.45648193359375}, {"start": 3600.62, "end": 3600.84, "word": " more", "probability": 0.9365234375}, {"start": 3600.84, "end": 3601.26, "word": " common", "probability": 0.93115234375}, {"start": 3601.26, "end": 3601.88, "word": " than", "probability": 0.8935546875}, {"start": 3601.88, "end": 3602.74, "word": " CLL", "probability": 0.9287109375}, {"start": 3602.74, "end": 3603.54, "word": " فيه", "probability": 0.55908203125}, {"start": 3603.54, "end": 3603.9, "word": " Large", "probability": 0.342529296875}, {"start": 3603.9, "end": 3604.64, "word": " Spleen", "probability": 0.6368408203125}, {"start": 3604.64, "end": 3605.24, "word": " which", "probability": 0.76220703125}, {"start": 3605.24, "end": 3605.4, "word": " is", "probability": 0.94921875}, {"start": 3605.4, "end": 3605.6, "word": " not", "probability": 0.9404296875}, {"start": 3605.6, "end": 3606.08, "word": " minimal", "probability": 0.85986328125}, {"start": 3606.08, "end": 3607.56, "word": " و", "probability": 0.84228515625}, {"start": 3607.56, "end": 3608.38, "word": " الرفنود", "probability": 0.52703857421875}, {"start": 3608.38, "end": 3608.62, "word": " is", "probability": 0.447021484375}, {"start": 3608.62, "end": 3608.96, "word": " rare", "probability": 0.74609375}, {"start": 3608.96, "end": 3610.46, "word": " Treatment،", "probability": 0.6180013020833334}, {"start": 3610.46, "end": 3611.16, "word": " بنشيل", "probability": 0.7090657552083334}, {"start": 3611.16, "end": 3611.28, "word": " ال", "probability": 0.80126953125}, {"start": 3611.28, "end": 3611.84, "word": " spleen", "probability": 0.5904541015625}, {"start": 3611.84, "end": 3613.12, "word": " مريح", "probability": 0.7232259114583334}, {"start": 3613.12, "end": 3613.92, "word": " المريض،", "probability": 0.8472900390625}, {"start": 3613.92, "end": 3614.14, "word": " هذي", "probability": 0.54931640625}, {"start": 3614.14, "end": 3614.4, "word": " أول", "probability": 0.95556640625}, {"start": 3614.4, "end": 3615.28, "word": " خطوة", "probability": 0.993408203125}, {"start": 3615.28, "end": 3616.4, "word": " و", "probability": 0.8203125}, {"start": 3616.4, "end": 3617.2, "word": " خصوصا", "probability": 0.97587890625}, {"start": 3617.2, "end": 3617.34, "word": " في", "probability": 0.96728515625}, {"start": 3617.34, "end": 3617.66, "word": " Stage", "probability": 0.355224609375}, {"start": 3617.66, "end": 3617.92, "word": " 1", "probability": 0.66357421875}, {"start": 3617.92, "end": 3618.1, "word": " و", "probability": 0.97412109375}, {"start": 3618.1, "end": 3618.28, "word": " 2", "probability": 0.744140625}], "temperature": 1.0}, {"id": 143, "seek": 364469, "start": 3620.17, "end": 3644.69, "text": "وال treatment بتعتمد على اللي هو reaction of spleen removal لو 40% من المرضى require chemotherapy after splenectomy with long with and it will be long term to maintain partial remission بيعتقوا alpha interferon available", "tokens": [2407, 6027, 5032, 39894, 34268, 2304, 3215, 15844, 13672, 1829, 31439, 5480, 295, 637, 28238, 17933, 45164, 3356, 4, 9154, 9673, 43042, 7578, 3651, 39238, 934, 4732, 268, 557, 8488, 365, 938, 365, 293, 309, 486, 312, 938, 1433, 281, 6909, 14641, 890, 3106, 4724, 1829, 34268, 4587, 14407, 8961, 25799, 266, 2435], "avg_logprob": -0.3550347277411708, "compression_ratio": 1.3076923076923077, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 3620.17, "end": 3621.33, "word": "وال", "probability": 0.5888671875}, {"start": 3621.33, "end": 3621.71, "word": " treatment", "probability": 0.07330322265625}, {"start": 3621.71, "end": 3622.33, "word": " بتعتمد", "probability": 0.88134765625}, {"start": 3622.33, "end": 3622.67, "word": " على", "probability": 0.60791015625}, {"start": 3622.67, "end": 3623.19, "word": " اللي", "probability": 0.710205078125}, {"start": 3623.19, "end": 3623.37, "word": " هو", "probability": 0.92822265625}, {"start": 3623.37, "end": 3623.87, "word": " reaction", "probability": 0.78759765625}, {"start": 3623.87, "end": 3624.23, "word": " of", "probability": 0.8564453125}, {"start": 3624.23, "end": 3624.67, "word": " spleen", "probability": 0.746826171875}, {"start": 3624.67, "end": 3625.45, "word": " removal", "probability": 0.93408203125}, {"start": 3625.45, "end": 3626.31, "word": " لو", "probability": 0.2086181640625}, {"start": 3626.31, "end": 3626.57, "word": " 40", "probability": 0.7177734375}, {"start": 3626.57, "end": 3626.81, "word": "%", "probability": 0.88720703125}, {"start": 3626.81, "end": 3627.15, "word": " من", "probability": 0.970703125}, {"start": 3627.15, "end": 3627.83, "word": " المرضى", "probability": 0.98193359375}, {"start": 3627.83, "end": 3628.51, "word": " require", "probability": 0.6826171875}, {"start": 3628.51, "end": 3629.13, "word": " chemotherapy", "probability": 0.79248046875}, {"start": 3629.13, "end": 3629.57, "word": " after", "probability": 0.85888671875}, {"start": 3629.57, "end": 3631.27, "word": " splenectomy", "probability": 0.812744140625}, {"start": 3631.27, "end": 3632.11, "word": " with", "probability": 0.5986328125}, {"start": 3632.11, "end": 3632.65, "word": " long", "probability": 0.72802734375}, {"start": 3632.65, "end": 3633.07, "word": " with", "probability": 0.5048828125}, {"start": 3633.07, "end": 3634.03, "word": " and", "probability": 0.5263671875}, {"start": 3634.03, "end": 3634.19, "word": " it", "probability": 0.96337890625}, {"start": 3634.19, "end": 3634.31, "word": " will", "probability": 0.89697265625}, {"start": 3634.31, "end": 3634.49, "word": " be", "probability": 0.875}, {"start": 3634.49, "end": 3634.93, "word": " long", "probability": 0.87451171875}, {"start": 3634.93, "end": 3636.79, "word": " term", "probability": 0.56396484375}, {"start": 3636.79, "end": 3638.11, "word": " to", "probability": 0.95166015625}, {"start": 3638.11, "end": 3638.77, "word": " maintain", "probability": 0.87890625}, {"start": 3638.77, "end": 3640.29, "word": " partial", "probability": 0.94384765625}, {"start": 3640.29, "end": 3640.97, "word": " remission", "probability": 0.776611328125}, {"start": 3640.97, "end": 3641.89, "word": " بيعتقوا", "probability": 0.5318359375}, {"start": 3641.89, "end": 3642.19, "word": " alpha", "probability": 0.671875}, {"start": 3642.19, "end": 3643.11, "word": " interferon", "probability": 0.753173828125}, {"start": 3643.11, "end": 3644.69, "word": " available", "probability": 0.81298828125}], "temperature": 1.0}, {"id": 144, "seek": 365913, "start": 3651.11, "end": 3659.13, "text": "المشكلة ان هناك انتباد لألفا انترفيروم وبالتالي استعمالته محدودة", "tokens": [6027, 2304, 8592, 28820, 3660, 16472, 34105, 4117, 16472, 2655, 3555, 18513, 5296, 10721, 46538, 995, 16472, 2655, 28480, 13546, 20498, 46599, 6027, 2655, 6027, 1829, 44713, 25957, 6027, 47395, 3714, 24401, 23328, 3660], "avg_logprob": -0.37723214796611243, "compression_ratio": 1.3333333333333333, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3651.11, "end": 3652.51, "word": "المشكلة", "probability": 0.66500244140625}, {"start": 3652.51, "end": 3653.07, "word": " ان", "probability": 0.56396484375}, {"start": 3653.07, "end": 3654.41, "word": " هناك", "probability": 0.825927734375}, {"start": 3654.41, "end": 3654.99, "word": " انتباد", "probability": 0.5476226806640625}, {"start": 3654.99, "end": 3655.77, "word": " لألفا", "probability": 0.5750274658203125}, {"start": 3655.77, "end": 3656.59, "word": " انترفيروم", "probability": 0.80849609375}, {"start": 3656.59, "end": 3657.09, "word": " وبالتالي", "probability": 0.9314453125}, {"start": 3657.09, "end": 3657.91, "word": " استعمالته", "probability": 0.9522705078125}, {"start": 3657.91, "end": 3659.13, "word": " محدودة", "probability": 0.9656982421875}], "temperature": 1.0}, {"id": 145, "seek": 367934, "start": 3661.0, "end": 3679.34, "text": "بهيك بنكون خلصنا المحاضرة ومرّينا على different types of chronic leukemia بما فيها ال myeloid و أكام من نوع من ال lymphoid و شكرا", "tokens": [3555, 3224, 1829, 4117, 44945, 30544, 16490, 1211, 9381, 8315, 9673, 5016, 46958, 25720, 4032, 29973, 11703, 1829, 8315, 15844, 819, 3467, 295, 14493, 45970, 29958, 4724, 15042, 8978, 11296, 2423, 452, 10590, 327, 4032, 5551, 4117, 10943, 9154, 8717, 45367, 9154, 2423, 31070, 17079, 4032, 13412, 4117, 23557], "avg_logprob": -0.2318750062584877, "compression_ratio": 1.243421052631579, "no_speech_prob": 0.0, "words": [{"start": 3661.0, "end": 3661.5, "word": "بهيك", "probability": 0.6094970703125}, {"start": 3661.5, "end": 3662.08, "word": " بنكون", "probability": 0.671142578125}, {"start": 3662.08, "end": 3663.32, "word": " خلصنا", "probability": 0.99365234375}, {"start": 3663.32, "end": 3664.82, "word": " المحاضرة", "probability": 0.971435546875}, {"start": 3664.82, "end": 3666.56, "word": " ومرّينا", "probability": 0.74453125}, {"start": 3666.56, "end": 3666.88, "word": " على", "probability": 0.88330078125}, {"start": 3666.88, "end": 3667.26, "word": " different", "probability": 0.751953125}, {"start": 3667.26, "end": 3667.84, "word": " types", "probability": 0.83837890625}, {"start": 3667.84, "end": 3668.12, "word": " of", "probability": 0.97998046875}, {"start": 3668.12, "end": 3668.56, "word": " chronic", "probability": 0.77880859375}, {"start": 3668.56, "end": 3669.24, "word": " leukemia", "probability": 0.848388671875}, {"start": 3669.24, "end": 3669.96, "word": " بما", "probability": 0.9580078125}, {"start": 3669.96, "end": 3670.22, "word": " فيها", "probability": 0.9814453125}, {"start": 3670.22, "end": 3670.34, "word": " ال", "probability": 0.759765625}, {"start": 3670.34, "end": 3671.0, "word": " myeloid", "probability": 0.7884114583333334}, {"start": 3671.0, "end": 3671.48, "word": " و", "probability": 0.92236328125}, {"start": 3671.48, "end": 3671.86, "word": " أكام", "probability": 0.5624186197916666}, {"start": 3671.86, "end": 3672.04, "word": " من", "probability": 0.97607421875}, {"start": 3672.04, "end": 3672.3, "word": " نوع", "probability": 0.97900390625}, {"start": 3672.3, "end": 3672.68, "word": " من", "probability": 0.95849609375}, {"start": 3672.68, "end": 3673.56, "word": " ال", "probability": 0.95947265625}, {"start": 3673.56, "end": 3674.48, "word": " lymphoid", "probability": 0.9228515625}, {"start": 3674.48, "end": 3675.4, "word": " و", "probability": 0.57373046875}, {"start": 3675.4, "end": 3679.34, "word": " شكرا", "probability": 0.8123372395833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 3680.2003125, "duration_after_vad": 3543.694374999986}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M.srt
new file mode 100644
index 0000000000000000000000000000000000000000..585b47d83ec4cfa395e79360291be2a93f9a83e4
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M.srt
@@ -0,0 +1,1903 @@
+1
+00:00:01,570 --> 00:00:07,110
+بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة
+
+2
+00:00:07,110 --> 00:00:15,190
+بعنوان myelodysplastic syndrome و myelodysplastic
+
+3
+00:00:15,190 --> 00:00:22,060
+syndrome هي عبارة عن مجموعة من الـ Disorders التي 
+
+4
+00:00:22,060 --> 00:00:27,640
+تتميز بواحد أو أكثر من واحد من ال peripheral blood
+
+5
+00:00:27,640 --> 00:00:30,960
+cytopenia شو يعني peripheral blood cytopenia يعني
+
+6
+00:00:30,960 --> 00:00:37,060
+قلة في one cellular element or more cellular
+
+7
+00:00:37,060 --> 00:00:42,330
+elements, and this is reflected in peripheral blood
+
+8
+00:00:42,330 --> 00:00:50,930
+as قلة/less in count طبعًا هذا الكلام ليه جاله
+
+9
+00:00:50,930 --> 00:00:53,270
+secondary to bone marrow dysfunction لأن ال bone
+
+10
+00:00:53,270 --> 00:00:58,730
+marrow مشتغل صح ببساطة ال bone marrow ما بيشتغل صح
+
+11
+00:00:58,730 --> 00:01:04,610
+في ال MDS ال bone marrow لا يستطيع أن ينتج خلايا 
+
+12
+00:01:04,610 --> 00:01:10,250
+effectively يعني بشكل سليم، وبالتالي الخلايا التي
+
+13
+00:01:10,250 --> 00:01:13,990
+تتكون هي عبارة عن defective cells,  بنجوسين هي عبارة
+
+14
+00:01:13,990 --> 00:01:19,610
+عن خلايا مشوهة/الخلايا غير طبيعية الجسم أول بأول
+
+15
+00:01:19,610 --> 00:01:24,630
+بيحاول يقتللها/يتخلص منها في ال bone marrow أو بعد 
+
+16
+00:01:24,630 --> 00:01:28,330
+خروجها في ال peripheral blood بسرعة/بفترة قصيرة 
+
+17
+00:01:28,330 --> 00:01:33,210
+محصلة هذا الكلام مدام الخلايا بتتكسر، محصلة هذا
+
+18
+00:01:33,210 --> 00:01:39,120
+الكلام أنه بيصير في shortage في blood cells، وهذا
+
+19
+00:01:39,120 --> 00:01:42,940
+يمكن أن يتم تفكيره بـ low blood count 
+
+20
+00:01:42,940 --> 00:01:46,240
+characteristics
+
+21
+00:01:46,240 --> 00:01:49,560
+كانوا يتميز بـ/هذا المرض varying degree of 
+
+22
+00:01:49,560 --> 00:01:54,940
+trilineage cytopenia ثلاث أنواع من الخلايا RBCs 
+
+23
+00:01:54,940 --> 00:02:01,040
+وWBCs وPlatelets dysplasia تشوهات normocellular or
+
+24
+00:02:01,040 --> 00:02:06,460
+hypercellular bone marrow وهذه المرضية قد تتطور إلى
+
+25
+00:02:06,460 --> 00:02:11,020
+أكيدلوكيميا ممكن يقلب ببساطة لـ اكيوت لوكيميا
+
+26
+00:02:11,020 --> 00:02:14,860
+Symptoms, signs and symptoms طبيعي جدًا في ال bone marrow
+
+27
+00:02:14,860 --> 00:02:20,480
+failure وبالتالي في انيميا ونيوتروبينيا وانفكشن 
+
+28
+00:02:20,480 --> 00:02:25,760
+فالانيميا is manifested by excessive tiredness
+
+29
+00:02:25,760 --> 00:02:31,040
+shortness of breath, pale skin that is correlated
+
+30
+00:02:31,040 --> 00:02:35,790
+with anemia، وهي عبارة عن shortage of RBCs والـ
+
+31
+00:02:35,790 --> 00:02:39,510
+neutropenia أو الـ infection serious infection مع
+
+32
+00:02:39,510 --> 00:02:44,330
+high fever that also can be caused by leukopenia 
+
+33
+00:02:44,330 --> 00:02:50,150
+بمعنى أن ما فيش white blood cells كفاية وبالذات الـ
+
+34
+00:02:50,150 --> 00:02:58,650
+neutrophils وبالتالي في few mature granulocytes والـ
+
+35
+00:02:58,650 --> 00:03:03,470
+excessive bruising اللي هو ماشي مع/طبعًا بيصير
+
+36
+00:03:03,470 --> 00:03:06,270
+فيه severe nose bleeding أو bleeding from the
+
+37
+00:03:06,270 --> 00:03:10,930
+gums that can be due to thrombocytopenia بمعنى أنه
+
+38
+00:03:10,930 --> 00:03:16,290
+ما فيش platelets كفاية في الجسم عشان to plug the holes
+
+39
+00:03:16,290 --> 00:03:21,530
+in damaged blood vessels incidence هذا عبارة عن 
+
+40
+00:03:21,530 --> 00:03:24,790
+disease of elderly people median age خمسة وستين
+
+41
+00:03:24,790 --> 00:03:30,850
+سنة إذا كان كان 
+
+42
+00:03:30,850 --> 00:03:36,380
+طبعًا في أقل من 10% من الحالات بيكونوا في أقل من 50 
+
+43
+00:03:36,380 --> 00:03:42,520
+سنة، وبالتالي ال incidence rate بتكون واحد لكل 100
+
+44
+00:03:42,520 --> 00:03:49,820
+ألف في ال population لكنها تزيد إلى واحد لكل ألف
+
+45
+00:03:49,820 --> 00:03:53,900
+من ال population في الأعمار الكبيرة اللي هي أكبر
+
+46
+00:03:53,900 --> 00:03:58,360
+من 60 سنة، وال male is slightly higher than female 
+
+47
+00:03:59,910 --> 00:04:04,490
+أسباب حطوا سبببن لهذا الموضوع كانوا فيه نوعين من
+
+48
+00:04:04,490 --> 00:04:09,330
+ال MDS نوع بيسموه de novo اللي هو الأصلي/الأساسي
+
+49
+00:04:09,330 --> 00:04:11,930
+واللي غالبًا associated with benzene exposure 
+
+50
+00:04:11,930 --> 00:04:16,410
+cigarette smoking and viruses وفي نوع منه
+
+51
+00:04:16,410 --> 00:04:20,830
+congenital بيسموه Fanconi's anemia نوع من ال
+
+52
+00:04:20,830 --> 00:04:25,010
+congenital disease بيسموها Fanconi's anemia sorry
+
+53
+00:04:25,010 --> 00:04:29,810
+هذا aplastic anemia النوع الثاني هو therapy related
+
+54
+00:04:29,810 --> 00:04:32,970
+و therapy induced and usually associated with 
+
+55
+00:04:32,970 --> 00:04:37,270
+alkylating agents, chemotherapy or radiation بيحصل
+
+56
+00:04:37,270 --> 00:04:42,970
+نتيجة أخذ المريض هذه الكيمياء دي/هذه المواد 
+
+57
+00:04:42,970 --> 00:04:49,030
+الكيميائية و هذه العلاجات بيصير في عنده MDS هذه صورة
+
+58
+00:04:49,030 --> 00:04:55,170
+جيدة جدا بتوضح لنا أو بتفهمنا بالضبط أنواع اللي هو
+
+59
+00:04:55,850 --> 00:04:59,790
+الـ hematological malignancies إذا فهمناها بنفهم
+
+60
+00:04:59,790 --> 00:05:06,750
+بنقدر نعرف تقسيمتها لأنه بيوضح اللي هو أذرع أو 
+
+61
+00:05:06,750 --> 00:05:13,350
+أذرع ال hemapoiesis كنا بنعرف أن ال stem cell ب
+
+62
+00:05:13,350 --> 00:05:18,750
+... كان proliferate يعني الأذرع المطلوبين 
+
+63
+00:05:18,750 --> 00:05:22,610
+proliferation و differentiation ماشي
+
+64
+00:05:25,890 --> 00:05:32,110
+ففي ال MDS الخلل بيكون في ال differentiation 
+
+65
+00:05:32,110 --> 00:05:37,590
+وبالتالي المحصلة لإيش؟ هي dysplastic form of cells 
+
+66
+00:05:37,590 --> 00:05:43,710
+وبما أن الخلل في كل أنواع الخلايا يبقى بيصير فيه 
+
+67
+00:05:43,710 --> 00:05:49,650
+trilineage cytopenia بينما لو كان الخلل في ذراع 
+
+68
+00:05:49,650 --> 00:05:53,550
+ال proliferation بتعمل مرض بيسموه اللي هو Non 
+
+69
+00:05:53,550 --> 00:05:58,790
+Leukemic Myeloproliferative Diseases و لو كان الخلل في 
+
+70
+00:05:58,790 --> 00:06:05,650
+الأذرع بالإضافة إلى dominance of mutant cell type يعني في 
+
+71
+00:06:05,650 --> 00:06:11,230
+prominent cell type which
+
+72
+00:06:11,230 --> 00:06:15,050
+is dominant بيتكون
+
+73
+00:06:15,050 --> 00:06:18,970
+الحالة Leukemia يمكن في ال Leukemia الأذرع
+
+74
+00:06:18,970 --> 00:06:31,500
+مضروبين، وهي فيه mutant genes في ال MDS الذراع ال
+
+75
+00:06:31,500 --> 00:06:34,880
+differentiation بيكون مضروب في ال non-leukemic
+
+76
+00:06:34,880 --> 00:06:38,440
+myeloproliferative disorders ال proliferation بيكون
+
+77
+00:06:38,440 --> 00:06:39,420
+مضروب 
+
+78
+00:06:41,880 --> 00:06:45,460
+طبعًا الـ Etiological agents عنده قائمة طويلة وعريضة
+
+79
+00:06:45,460 --> 00:06:49,480
+جداً ممكن تكون سبب لهذه الأمراض/لهذا المرض زي الـ 
+
+80
+00:06:49,480 --> 00:06:52,000
+tobacco, ionizing radiation, organic chemicals 
+
+81
+00:06:52,000 --> 00:06:57,180
+بأنواعها، heavy metals, herbicides و pesticides و
+
+82
+00:06:57,180 --> 00:07:00,980
+fertilizers بمجموعة كثيرة من ال alkylating agents و
+
+83
+00:07:00,980 --> 00:07:07,340
+petroleum و هكذا طبعًا هذا محصلته كـ chromosome 
+
+84
+00:07:07,340 --> 00:07:11,060
+abnormality وسجلت حالات chromosome abnormality في
+
+85
+00:07:11,060 --> 00:07:15,380
+أكثر من 50% من الحالات وفي حوالي كل حالات 
+
+86
+00:07:15,380 --> 00:07:21,580
+ال secondary أو ال therapy related MDS طبعًا هذه 
+
+87
+00:07:21,580 --> 00:07:26,700
+عبارة عن أمثلة فقط لحالات ال chromosome ال
+
+88
+00:07:26,700 --> 00:07:30,660
+abnormality اللي بتتصاحب أو بتكون موجودة في ال MDS 
+
+89
+00:07:30,660 --> 00:07:37,120
+فهي زي ما أنتم شايفين 5q minus ماشي 7q
+
+90
+00:07:37,120 --> 00:07:45,490
+11q  منظومة/كذا عدد كبيرة من chromosome 
+
+91
+00:07:45,490 --> 00:07:48,550
+abnormality طبعًا من أشهرها deletion of the long
+
+92
+00:07:48,550 --> 00:07:57,010
+arm of chromosome 5 5q minus syndrome وحتى
+
+93
+00:07:57,010 --> 00:08:06,490
+اليوم في يعني نوع اسمه 5q minus syndrome أو 5q 
+
+94
+00:08:06,490 --> 00:08:12,800
+minus MDS هو مرتبط بشكل كبير بـ refractory anemia with
+
+95
+00:08:12,800 --> 00:08:14,580
+ring sideroblasts
+
+96
+00:08:18,460 --> 00:08:22,520
+ويشكل حوالي 70% هذا الـ cytogenetic abnormality
+
+97
+00:08:22,520 --> 00:08:27,520
+of this type طبعًا في منطقة الـ q arm of chromosome
+
+98
+00:08:27,520 --> 00:08:32,220
+number 7 وجدوا أنه في معظم الجينات اللي مسؤولة عنهم
+
+99
+00:08:32,220 --> 00:08:35,980
+growth and growth factors وبالتالي غيابها معناته
+
+100
+00:08:35,980 --> 00:08:40,440
+ما فيش growth factors زي IL 3 أو 4 أو 5 أو GM-CSF و
+
+101
+00:08:40,440 --> 00:08:46,190
+M-CSF وبالتالي ال receptors أيضًا كمان غائبة لأن هو
+
+102
+00:08:46,190 --> 00:08:50,090
+gene and receptor for growth factors and their receptors 
+
+103
+00:08:50,090 --> 00:08:55,910
+وبالتالي طبعًا فقد هذه المواد هيؤدي إلى
+
+104
+00:08:55,910 --> 00:09:01,810
+disruption or overdraft of hemopoiesis 
+
+105
+00:09:01,810 --> 00:09:09,190
+monosomy 7 and 7q- أيضًا associated with secondary
+
+106
+00:09:09,190 --> 00:09:16,490
+MDS ويوجدوا في هذه المنطقة في ال major surface
+
+107
+00:09:16,490 --> 00:09:23,750
+glycoprotein 130 وبالتالي غيابه معناته في غياب لـ 
+
+108
+00:09:23,750 --> 00:09:26,710
+neutrophil function and susceptibility to
+
+109
+00:09:26,710 --> 00:09:29,930
+bacterial infections غالبًا لأن 
+
+110
+00:09:29,930 --> 00:09:34,870
+ال granulocyte chemotactic activity is defected 
+
+111
+00:09:34,870 --> 00:09:39,310
+11q- deletion of 11q
+
+112
+00:09:41,750 --> 00:09:46,730
+يشكل هذا حوالي 20% من حالات refractory 
+
+113
+00:09:46,730 --> 00:09:50,630
+anemia with ringed sideroblasts و لسه abnormality
+
+114
+00:09:50,630 --> 00:09:55,030
+غالبًا associated with raised iron stores تلاقي الـ
+
+115
+00:09:55,030 --> 00:09:58,250
+iron stores عالية و بيصير فيها ringed sideroblasts
+
+116
+00:09:58,250 --> 00:10:06,030
+السبب في ذلك وجود الجين المسؤول عن ال H subunit of 
+
+117
+00:10:06,030 --> 00:10:12,510
+ferritin في هذه المنطقة وعلى chromosome رقم 11 وذلك 
+
+118
+00:10:12,510 --> 00:10:21,150
+أيضًا ما يفسر زيادة iron store abnormality في 
+
+119
+00:10:21,150 --> 00:10:28,830
+chromosome 17 طبعًا inversion of 17q قالوا في هذه
+
+120
+00:10:28,830 --> 00:10:35,310
+المنطقة يوجد ال p53 أو tumor suppressor gene اللى
+
+121
+00:10:35,310 --> 00:10:42,420
+موجود في كثير من الحالات من ال AML بالذات
+
+122
+00:10:42,420 --> 00:10:46,520
+لما تيجي في ال blast phase من ال plastic phase من ال
+
+123
+00:10:46,520 --> 00:10:53,480
+chronic phase لـ ال blast phase و تقريبًا حوالي 5% 
+
+124
+00:10:53,480 --> 00:11:03,680
+من حالات ال primary MDS طبعًا هذا بيدي إلى dysplastic 
+
+125
+00:11:03,680 --> 00:11:06,660
+features of cells and neutrophil 
+
+126
+00:11:06,660 --> 00:11:13,510
+vacuolization abnormality في chromosome 3 بعمل mega 
+
+127
+00:11:13,510 --> 00:11:20,210
+karyocytes وthrombocytosis وهذا غالبًا مصحوب بهذا
+
+128
+00:11:20,210 --> 00:11:25,230
+ال abnormality طيب شوفوا أهمية/importance of
+
+129
+00:11:25,230 --> 00:11:28,670
+indication of chromosome abnormality يقول رقم واحد
+
+130
+00:11:28,670 --> 00:11:32,270
+to confirm diagnosis رقم اثنين to know the stage
+
+131
+00:11:32,270 --> 00:11:36,090
+of disease رقم ثلاث to know the direction of 
+
+132
+00:11:36,090 --> 00:11:41,420
+progression of disease تطور الحالة المرضية رقم
+
+133
+00:11:41,420 --> 00:11:45,440
+أربعة Multiple Genetic Abnormalities معناته المريض في 
+
+134
+00:11:45,440 --> 00:11:53,760
+مراحله المتأخرة Pattern of MDS Evolution كيف يتطور
+
+135
+00:11:53,760 --> 00:11:59,340
+هذا المرض ومراحل تطوره جايبوا يبدأ ب stable group
+
+136
+00:11:59,340 --> 00:12:02,840
+with no increase in bone marrow blasts
+
+137
+00:12:08,420 --> 00:12:10,240
+والخلايا كانت مضروبة ولكن مستقلة والخلايا كانت 
+
+138
+00:12:10,240 --> 00:12:16,340
+مضروبة ولكن مستقلة والخلايا كانت مضروبة ولكن مستقلة
+
+139
+00:12:16,340 --> 00:12:19,840
+والخلايا كانت مضروبة ولكن مستقلة والخلايا كانت 
+
+140
+00:12:19,840 --> 00:12:20,040
+والخلايا كانت مضروبة ولكن مستقلة والخلايا كانت 
+
+141
+00:12:20,040 --> 00:12:20,660
+والخلايا كانت مضروبة ولكن مستقلة والخلايا كانت
+
+142
+00:12:20,660 --> 00:12:23,100
+مضروبة ولكن مستقلة والخلايا كانت مضروبة ولكن مستقلة
+
+143
+00:12:23,100 --> 00:12:27,720
+والخلايا كانت مضروبة ولكن مستقلة والخلايا كانت
+
+144
+00:12:27,720 --> 00:12:33,370
+مضروبة ولكن مستقلة .. نمرة تلاتة بيصير في زيادة في
+
+145
+00:12:33,370 --> 00:12:38,630
+ال blast count و .. طبعا حتى في غياب ال
+
+146
+00:12:38,630 --> 00:12:43,310
+cytogenetic changes و هذا هي المراحل المختلفة ده
+
+147
+00:12:43,310 --> 00:12:47,370
+هي normal stem cell لكنها تعرضت ل insult ومن ال
+
+148
+00:12:47,370 --> 00:12:51,610
+insult genetic insult ممكن يكون age or viral or
+
+149
+00:12:51,610 --> 00:12:58,690
+chemical or radiochemical ماذا يحصل؟ يحصل فيه
+
+150
+00:12:58,690 --> 00:13:02,910
+Stable New Abnormal Clone  Clue abnormal لكنها
+
+151
+00:13:02,910 --> 00:13:05,990
+مازالت مستقلة يعني المريض في هذه الحالة بيكون 
+
+152
+00:13:05,990 --> 00:13:12,090
+hematologically silent إذا اتعرضت الجينات للـ
+
+153
+00:13:12,090 --> 00:13:16,550
+mutation يحصل في growth advantage و يدخل المريض في
+
+154
+00:13:16,550 --> 00:13:20,420
+مرحلة بيسموها pre-leukemic status لو فحصنا ال
+
+155
+00:13:20,420 --> 00:13:24,220
+karyotype في هذه المرحلة بيلاقيها abnormal يعني
+
+156
+00:13:24,220 --> 00:13:27,740
+قبل هيك بيكون normal أو نعم قبل هيك بيكون normal
+
+157
+00:13:27,740 --> 00:13:33,720
+طبعا once the karyotype is abnormal يعني فيه
+
+158
+00:13:33,720 --> 00:13:36,720
+chromosomal abnormality بيصير فيه inhibition
+
+159
+00:13:36,720 --> 00:13:41,920
+لـ normal hemopoiesis وتنتهي غالبا منها بتجلب لمين؟
+
+160
+00:13:41,920 --> 00:13:45,360
+لللوكيميا بتجلب لللوكيميا بيصير في فلان لوكيميا
+
+161
+00:13:45,360 --> 00:13:50,320
+clone is produced يبقى هذه هي المراحل المختلفة
+
+162
+00:13:50,320 --> 00:13:54,920
+Normal stem cell تعرضت ل install تكوين new
+
+163
+00:13:54,920 --> 00:13:58,580
+abnormal clone لو فحصنا ال proto-oncogene أو ال
+
+164
+00:13:58,580 --> 00:14:02,820
+جينات بيكون by karyotyping sorry  للكروموسومات by
+
+165
+00:14:02,820 --> 00:14:05,860
+karyotyping بتكون normal ومافي blast cell في هذه
+
+166
+00:14:05,860 --> 00:14:09,300
+الحالة لكن once a mutation is occurred بيصير في
+
+167
+00:14:09,300 --> 00:14:12,960
+growth advantage بيخش المريض في preleukemic status
+
+168
+00:14:12,960 --> 00:14:16,690
+لو فحصنا ال karyotyping على جهة abnormal متى ما
+
+169
+00:14:16,690 --> 00:14:19,870
+صارت abnormal يعني فيه نهبش لـ normal hemopoiesis
+
+170
+00:14:19,870 --> 00:14:25,550
+يعني اللي في الغالب تجلب لللوكيميا classification
+
+171
+00:14:25,550 --> 00:14:30,910
+of FAP قسموها إلى خمس أنواع مختلفة هذا الجدول
+
+172
+00:14:30,910 --> 00:14:35,470
+بلخصنا الأنواع المختلفة كلها اللي إن شاء الله
+
+173
+00:14:35,470 --> 00:14:40,310
+بنجيها بالتفصيل قدامي بس هذا الجدول مهم ماشي إيش
+
+174
+00:14:40,310 --> 00:14:43,860
+بيقول الأنواع هي خمس أنواع Refractory Anemia
+
+175
+00:14:43,860 --> 00:14:46,180
+Refractory Anemia with Ringed Sideroblast
+
+176
+00:14:46,180 --> 00:14:48,800
+Refractory Anemia with Excess Blasts هاي
+
+177
+00:14:48,800 --> 00:14:51,780
+الاختصارات Refractory Anemia with Excess Blasts
+
+178
+00:14:51,780 --> 00:14:52,700
+and Transformation Refractory Anemia with
+
+179
+00:14:52,700 --> 00:14:53,860
+Excess Blasts and Transformation and Chronic
+
+180
+00:14:53,860 --> 00:14:55,400
+Myelomonocytic Leukemia
+
+181
+00:15:04,420 --> 00:15:08,400
+نقدر نشوف الـ Blast في الـ Peripheral Blood والـ
+
+182
+00:15:08,400 --> 00:15:11,580
+Bone Marrow ثم نشوف الـ Monocytes لإنه في النوع
+
+183
+00:15:11,580 --> 00:15:16,160
+فيه الـ Monocytes ثم Ringed Sideroblast لإنه في
+
+184
+00:15:16,160 --> 00:15:19,560
+النوع بيصير فيه Ringed Sideroblast ونشوف إذا كان
+
+185
+00:15:19,560 --> 00:15:24,000
+فيه other features can be compared فالـ Refractor
+
+186
+00:15:24,000 --> 00:15:26,560
+يقول إن الـ Blast في ال Peripheral Blood يكون أقل
+
+187
+00:15:26,560 --> 00:15:29,580
+من واحد في ال Bone Marrow أقل من خمسة وأنا واحدة
+
+188
+00:15:29,580 --> 00:15:35,750
+عبارة عن Normal Percentage النسبة أقل من واحد ال
+
+189
+00:15:35,750 --> 00:15:40,090
+ringed sideroblast بتكون أقل من خمسة عشر ويكون المريض
+
+190
+00:15:40,090 --> 00:15:44,870
+عنده أنيميا إنها اللي associated with يعني اللي
+
+191
+00:15:44,870 --> 00:15:48,910
+بيشبهه أو تطوره اللي هو النوع الثاني اللي هو
+
+192
+00:15:48,910 --> 00:15:53,100
+refractory anemia و ringed sideroblast الـ blast يكون
+
+193
+00:15:53,100 --> 00:15:55,720
+أقل من واحد في الـ peripheral blood وأقل من خمسة
+
+194
+00:15:55,720 --> 00:15:59,840
+في الـ bone marrow يعني still ال blast لم يتكون  monocyte
+
+195
+00:15:59,840 --> 00:16:05,360
+أيضا كذلك لكن اللي بيميزها وجود ringed sideroblast
+
+196
+00:16:05,360 --> 00:16:09,980
+اسمها with ringed sideroblast ماشي؟ يعني في زيادة
+
+197
+00:16:09,980 --> 00:16:15,340
+في إيش؟ في ال iron هو طبعا في هذه الحالة بيكون في
+
+198
+00:16:15,340 --> 00:16:22,800
+Anemia وفي Refractory Cytopenia لشيء بتدي علاج لا
+
+199
+00:16:22,800 --> 00:16:27,740
+يستجيب Refractory Anemia و Excessive Blasts هي بدت
+
+200
+00:16:27,740 --> 00:16:31,160
+تزيد ال blast يعني أقل من خمسة في ال peripheral
+
+201
+00:16:31,160 --> 00:16:35,880
+blood من خمسة لعشرين في ال bone marrow يعني لسه
+
+202
+00:16:35,880 --> 00:16:40,280
+ماوصلت لثلاثين ما نقدرش نسميه leukemia وأقل من واحد
+
+203
+00:16:40,280 --> 00:16:45,440
+ال monocyte أقل من خمسة عشر الـ Sidroblast وال
+
+204
+00:16:45,440 --> 00:16:49,960
+الأنيم .. وال .. ال .. طبعا ال other feature اللي
+
+205
+00:16:49,960 --> 00:16:54,000
+هو Cytopenia و Refractory Anemia والشغلات هذه
+
+206
+00:16:54,000 --> 00:16:58,640
+الرابع اللي هو Refractory Anemia و Excess
+
+207
+00:16:58,640 --> 00:17:03,780
+Blasts in Transformation إيش يعني؟ بدت تقلب فشفنا
+
+208
+00:17:03,780 --> 00:17:08,250
+ال blast في ال peripheral أكتر من خمسة بعد تجربة
+
+209
+00:17:08,250 --> 00:17:12,590
+الـ bone marrow من عشرين لثلاثين يعني تقريبا لكيميا
+
+210
+00:17:12,590 --> 00:17:17,650
+تقريبا في طريقة إلى اللوكيميا يعني خلاص بدأت تجلب
+
+211
+00:17:17,650 --> 00:17:22,450
+in transformation  الـ monocyte أقل من واحد Ringed cell
+
+212
+00:17:22,450 --> 00:17:27,110
+plus أقل من خمسة ونبدأ نشوف  our body in plus cell
+
+213
+00:17:27,110 --> 00:17:35,360
+وفي زيادة في ال granulocyte count  لـ Granulocyte
+
+214
+00:17:35,360 --> 00:17:40,860
+والـ pro وطبعا بشكل أساسي Chronic Myelomonocytic
+
+215
+00:17:40,860 --> 00:17:44,880
+leukemia  البلاستقال من خمسة ال .. في ال peripheral
+
+216
+00:17:44,880 --> 00:17:49,860
+blood أقل من عشرين في الـ bone marrow وأكثر من واحد لأن
+
+217
+00:17:49,860 --> 00:17:54,940
+هذا هو العامل اللي بيخصها يعني أكثر من ألف
+
+218
+00:17:54,940 --> 00:18:01,560
+monocytes في ال peripheral blood وأقل من 15 Ringed
+
+219
+00:18:01,560 --> 00:18:06,160
+Sideroblast وفي زيادة لـ promonocytes هذا جدول
+
+220
+00:18:06,160 --> 00:18:09,280
+تقريبا بوضح لي الأنواع المختلفة واللي إن شاء الله
+
+221
+00:18:09,280 --> 00:18:14,020
+هنجي إليها دائما بالتفصيل واحد ورا التانية وأول
+
+222
+00:18:14,020 --> 00:18:17,500
+هذه الأنواع اللي هو Refractory Anemia قلنا بيصير
+
+223
+00:18:17,500 --> 00:18:21,300
+فيها by definition dysplasia لـ erythroid series only
+
+224
+00:18:21,300 --> 00:18:25,400
+clinically في أنيميا which is refractory to
+
+225
+00:18:25,400 --> 00:18:29,590
+treatment تديها كل المقويات ما تستجيب للعلاج  ميرو
+
+226
+00:18:29,590 --> 00:18:32,790
+blast أقل من واحد في الـ peripheral blood أقل من خمسة في
+
+227
+00:18:32,790 --> 00:18:37,190
+الـ bone marrow ومافيش sideroblast أقل من خمسة عشر ومافيش
+
+228
+00:18:37,190 --> 00:18:42,970
+our body وكانوا you have to exclude other
+
+229
+00:18:42,970 --> 00:18:50,610
+etiological agents إيش يعني؟ أي أسباب أخرى بتعمل
+
+230
+00:18:50,610 --> 00:18:55,770
+هذه الصورة لازم تستثنيها منها drug or toxin
+
+231
+00:18:55,770 --> 00:18:59,650
+exposure Viral Infection, Vitamin Deficiency,
+
+232
+00:19:00,110 --> 00:19:04,090
+Congenital Disease استثناء هذه الشغلات ضد الـ
+
+233
+00:19:04,090 --> 00:19:09,830
+Refractory Anemia هي التشخيص الدنيا تجهي من خمسة
+
+234
+00:19:09,830 --> 00:19:14,190
+لعشر حالات في عشرة في المية من الـ MDS وهي تصيب
+
+235
+00:19:14,190 --> 00:19:18,230
+الاختيارية morphologically بنشوف anisocytosis poikilocytosis
+
+236
+00:19:18,230 --> 00:19:24,310
+في ال peripheral smear وفي dyserythropoiesis with
+
+237
+00:19:24,310 --> 00:19:28,650
+nuclear abnormality بنشوف أشهر حاجة megaloblastoid
+
+238
+00:19:28,650 --> 00:19:33,830
+changes megaloblastoid كبيرة blastoid من blast
+
+239
+00:19:33,830 --> 00:19:40,390
+ماشي يعني immature changes وهي أقل من 15% ringed
+
+240
+00:19:40,390 --> 00:19:46,850
+sideroblast  genetics 25% may have genetic abnormality
+
+241
+00:19:46,850 --> 00:19:50,190
+وليه ال diagnosis قالوا بيعيش ال median survival
+
+242
+00:19:50,920 --> 00:19:57,460
+time حوالي 66 شهر لكن 6% منهم بيجلبوا لـ acute
+
+243
+00:19:57,460 --> 00:20:02,840
+leukemia بيتطور المرض عندهم to acute leukemia وهذا
+
+244
+00:20:02,840 --> 00:20:08,100
+ال peripheral smear أي anisocytosis poikilocytosis طبعا
+
+245
+00:20:08,100 --> 00:20:10,920
+الـ anisocytosis اختلاف الحجوم poikilocytosis
+
+246
+00:20:10,920 --> 00:20:15,840
+اختلاف الأشكال وتخيلوا الـ bone marrow شايفين كيف
+
+247
+00:20:15,840 --> 00:20:21,900
+الخلايا تتكسر حتى في الـ bone marrow وهي بتكون خلايا
+
+248
+00:20:21,900 --> 00:20:26,240
+مشوهة معظم الخلايا اللي موجودة هي عبارة عن خلايا
+
+249
+00:20:26,240 --> 00:20:32,280
+مشوهة وهي megaloblastoid changes كبيرة لمن؟
+
+250
+00:20:32,280 --> 00:20:41,440
+لخلايا الـ RBCs megaloblastoid تكبر كتير المرة
+
+251
+00:20:41,440 --> 00:20:43,820
+الثانية الـ refractory يعني ما هو الـ Ring sideroblast
+
+252
+00:20:43,820 --> 00:20:46,480
+وهذا بيصير فيه dysplasia 
+
+253
+00:20:49,160 --> 00:20:52,060
+Clinically, anemia is refractory to hematinic
+
+254
+00:20:52,060 --> 00:20:56,080
+therapy زي الأولاني ونفس الحكاية ال myeloblast في
+
+255
+00:20:56,080 --> 00:20:59,320
+الـ peripheral blood أقل من خمسة وفي الـ bone
+
+256
+00:20:59,320 --> 00:21:03,540
+marrow أقل من واحد وأقل من خمسة في الـ bone marrow
+
+257
+00:21:03,540 --> 00:21:07,760
+في Ringed Sideroblast وفي sideroblast لكن you have
+
+258
+00:21:07,760 --> 00:21:12,540
+to exclude antituberculosis drug والـ alcohol و
+
+259
+00:21:12,540 --> 00:21:16,220
+الـ lead الدمولوجي من عشر أو اثنا عشر في المية من الـ MDS
+
+260
+00:21:16,220 --> 00:21:19,700
+حالات الـ MDS وبيصيب الاختيارية والـ males أكثر من
+
+261
+00:21:19,700 --> 00:21:22,700
+الـ females و morphologically بنشوف pattern
+
+262
+00:21:22,700 --> 00:21:27,460
+dimorphic يعني شكلين يعني الخلايا لها شكلين on
+
+263
+00:21:27,460 --> 00:21:32,740
+peripheral smears معظم الـ RBCs normochromic لكن في
+
+264
+00:21:32,740 --> 00:21:38,340
+second population وهو hypochromic طبعا في this
+
+265
+00:21:38,340 --> 00:21:42,140
+يعني abnormal erythropoiesis في nuclear
+
+266
+00:21:42,140 --> 00:21:46,460
+abnormalities وبنشوف ال megaloblastoid changes
+
+267
+00:21:48,130 --> 00:21:54,430
+مفروض يقل من 15% Ringed Sideroblast الـ Ringed Sideroblast
+
+268
+00:21:54,430 --> 00:21:58,130
+هي عبارة عن erythroid الـ precursor cell فيها أكثر
+
+269
+00:21:58,130 --> 00:22:05,170
+من عشرة Siderotic granules وهذه Siderotic granules
+
+270
+00:22:05,170 --> 00:22:12,730
+in circling تقريبا ثلث أو أكثر من ثلث الأنواع if
+
+271
+00:22:12,730 --> 00:22:21,080
+excess blast presence this dictates diagnosis حتى
+
+272
+00:22:21,080 --> 00:22:27,740
+بالرغم من ال percentage of ringed sideroblast ماشي
+
+273
+00:22:27,740 --> 00:22:32,700
+بغض النظر عن وجود ال ringed sideroblast إذا شفنا ال
+
+274
+00:22:32,700 --> 00:22:37,360
+blast موجودة هذا على
+
+275
+00:22:37,360 --> 00:22:43,500
+طول بيخلنا نفكر في اتجاه آخر genetically
+
+276
+00:22:45,410 --> 00:22:48,710
+في كلونة أو كروموسوم ال abnormality أقل من 10% من
+
+277
+00:22:48,710 --> 00:22:53,550
+الحالات develop such abnormality وبالتالي you have
+
+278
+00:22:53,550 --> 00:22:58,830
+to reassess their diagnoses ال median survival
+
+279
+00:22:58,830 --> 00:23:07,010
+time ست سنوات و 72 شهر و 1-2% من الحالات بيجلب لـ
+
+280
+00:23:07,010 --> 00:23:13,170
+acute leukemia وهي dimorphic شايفين الشكلين 
+
+281
+00:23:13,760 --> 00:23:22,680
+اللي موجودين للـ RBCs وهي Ringed Cedroplast كما 
+
+282
+00:23:22,680 --> 00:23:27,860
+تشايفين هي Ringed Cedroplast أكثر من تلت الخلايا is
+
+283
+00:23:27,860 --> 00:23:34,520
+ringed by cedrotic body وهذا هي Ringed Cedroplast
+
+284
+00:23:36,170 --> 00:23:39,870
+هو الـ megaloblastoid الاختلافات التي نشاهدها في
+
+285
+00:23:39,870 --> 00:23:45,370
+الـ RBC's تكبر و نيكلياسها غير طبيعية و كل شيء
+
+286
+00:23:45,370 --> 00:23:52,250
+فيها غير طبيعي نوع التالت reflector يعني ما with
+
+287
+00:23:52,250 --> 00:23:59,170
+excessive blast ياله by definition هذافي بيكون
+
+288
+00:23:59,170 --> 00:24:03,750
+خمسة لتسعة عشر في المئة من ال myeloplast present
+
+289
+00:24:03,750 --> 00:24:07,570
+في الـ bone marrow قسموها لنوعين قالوا إذا الـ blast
+
+290
+00:24:07,570 --> 00:24:12,590
+من خمسة لتسعة في المئة في الـ bone marrow وأقل من
+
+291
+00:24:12,590 --> 00:24:15,890
+خمسة في الـ blood بيسموها Refractory Anemia
+
+292
+00:24:15,890 --> 00:24:20,930
+Blast I وإذا الـ blast أقل من عشرة لتسعة عشر في
+
+293
+00:24:20,930 --> 00:24:25,590
+المئة في الـ bone marrow وفي أول root body بيسموها
+
+294
+00:24:25,590 --> 00:24:32,510
+Refractory Anemia Blast II الدينالوجيا بشكل
+
+295
+00:24:32,510 --> 00:24:36,570
+أربعين في المئة من حالات الـ MDS بتجيب الاختيارية و
+
+296
+00:24:36,570 --> 00:24:42,800
+morphologically في Dysplasia في كل أنواع الخلايا في
+
+297
+00:24:42,800 --> 00:24:49,380
+نتروفيل أبنرمالتي التي قد تشمل Hypogranulation
+
+298
+00:24:49,380 --> 00:24:55,180
+Hypersegmentation سودو بالكرهوت Anomaly اللي هو
+
+299
+00:24:55,180 --> 00:24:59,740
+عبارة عن Hypersegmentation مع بار بالـ shape
+
+300
+00:24:59,740 --> 00:25:03,620
+للنكلياس
+
+301
+00:25:03,620 --> 00:25:08,050
+بعدين سودو تشيديا كيجاشي Granulesفي abnormality
+
+302
+00:25:08,050 --> 00:25:11,130
+filigranous of neutrophil ميجا كاريوسايت
+
+303
+00:25:11,130 --> 00:25:14,970
+abnormality ممكن نشوف hybolobulation وممكن نشوف
+
+304
+00:25:14,970 --> 00:25:21,770
+micro ميجا كاريوسايت في هذا النوع الـ morphology
+
+305
+00:25:21,770 --> 00:25:26,210
+erythroid glucosal abnormality ممكن نشوف فيها
+
+306
+00:25:26,210 --> 00:25:29,270
+abnormal lobulation ميجا أروبلاستويد and
+
+307
+00:25:29,270 --> 00:25:35,390
+multinucleation وإذا كان الـ myeloblast ممكن
+
+308
+00:25:35,390 --> 00:25:40,870
+تكون من 0 لـ 19 في الـ blood أو من خمسة لتسعة عشر في 
+
+309
+00:25:40,870 --> 00:25:46,530
+الـ bone marrow غالبا الـ bone marrow is hypercellular فقط
+
+310
+00:25:46,530 --> 00:25:50,110
+عشر لخمسة عشر في المئة hypercellular وفى abnormal
+
+311
+00:25:50,110 --> 00:25:55,410
+localization of immature بكاسر اللى هو abnormal
+
+312
+00:25:55,410 --> 00:26:02,780
+localization of immature precursor cell may be
+
+313
+00:26:02,780 --> 00:26:07,500
+present المهم في أن خلايا بيكون عصرتها سنة ستة عشر
+
+314
+00:26:07,500 --> 00:26:14,640
+تقصدى ثلاثة عشر ثلاثة و ثلاثين ميو سبعة عشر و النوع
+
+315
+00:26:14,640 --> 00:26:20,480
+الوحيد من الـ من الـ myelodysplastic syndrome which
+
+316
+00:26:20,480 --> 00:26:27,580
+have relevant phenotype category
+
+317
+00:26:27,580 --> 00:26:33,440
+يعني Genetic طبعا سجلت حالات كثيرة منها كرموزومة
+
+318
+00:26:33,440 --> 00:26:36,820
+لأبنورماليتي من ثلاثين لخمسين في المئة من الحالات
+
+319
+00:26:36,820 --> 00:26:42,540
+Prognosis median survival time لـ type one طبعا ثلاثة عشر
+
+320
+00:26:42,540 --> 00:26:47,480
+شهر و type two عشر أشهر وخمسة وعشرين في المئة من
+
+321
+00:26:47,480 --> 00:26:50,520
+حالات type one تجلب لاللوكيميا بينما ثلاثة و ثلاثين
+
+322
+00:26:50,520 --> 00:26:56,020
+في المئة من اللي هو type two بجلب لاللوكيميا وهي
+
+323
+00:26:56,020 --> 00:27:00,690
+الـ hypercellular bone marrow مليان خلايا وهي الـ
+
+324
+00:27:00,690 --> 00:27:08,170
+Blast and hypogranulation اللي موجود وهي 
+
+325
+00:27:08,170 --> 00:27:13,210
+الـ megaloblastoid اللي ملاحظها with our sorry
+
+326
+00:27:13,210 --> 00:27:16,530
+myeloblast with our root body لأنه بنتحكي على
+
+327
+00:27:16,530 --> 00:27:21,390
+blast the excess blast وهي فيه vacuoles في الـ
+
+328
+00:27:21,390 --> 00:27:25,830
+cytoplasm وهي كل الـ abnormality بتاعة الـ
+
+329
+00:27:25,830 --> 00:27:31,980
+neutrophil سواء كانت Shiryak-Higashi بأنواع مختلفة
+
+330
+00:27:31,980 --> 00:27:35,300
+آخر هذه الأنواع اللي هو Refractory Anemia with
+
+331
+00:27:35,300 --> 00:27:40,660
+excess blast in transformation بشكل
+
+332
+00:27:40,660 --> 00:27:47,960
+21 لـ 30% من حالات اللي هو sorry في 21 لـ 30% من الـ
+
+333
+00:27:47,960 --> 00:27:52,620
+blast في الـ bone marrow و أكثر من 5% blast في الـ
+
+334
+00:27:52,620 --> 00:27:56,520
+peripheral blood و في excessive number و mono size
+
+335
+00:27:57,540 --> 00:28:02,040
+وهي normal hyper or hypercellular bone marrow
+
+336
+00:28:02,040 --> 00:28:05,960
+وبيشكل 25% من الحالات
+
+337
+00:28:11,280 --> 00:28:16,020
+اللي هو بيكون فيه خمسة لعشرين في المئة blast في الـ
+
+338
+00:28:16,020 --> 00:28:19,880
+bone marrow أقل من خمسة في المئة في الـ blood stream في
+
+339
+00:28:19,880 --> 00:28:24,960
+cytopenia في at least in at least two line وفي
+
+340
+00:28:24,960 --> 00:28:28,260
+normal or hypercellular bone marrow بشكل خمسة
+
+341
+00:28:28,260 --> 00:28:35,480
+وخمسة عشر لعشرين في المئة من حالات الـ MDS IUCMML
+
+342
+00:28:35,480 --> 00:28:40,370
+splenomegaly مايكيلوب popular skin infiltration
+
+343
+00:28:40,370 --> 00:28:46,250
+بيكون في monocytic plural أو pericardial effusion
+
+344
+00:28:46,250 --> 00:28:52,210
+وفي جوناع الـ myelomonocytic leukemia مرات بيكون في
+
+345
+00:28:52,210 --> 00:28:57,990
+myeloproliferative dysplasia أو myelodysplastic
+
+346
+00:28:57,990 --> 00:29:02,070
+syndrome pallor, bleeding, hepatosplenomegaly
+
+347
+00:29:02,070 --> 00:29:03,930
+و skin involvement
+
+348
+00:29:06,850 --> 00:29:13,910
+هذا ما يتعلق بالأنواع اللي هو الـ myelodysplasia
+
+349
+00:29:13,910 --> 00:29:19,070
+according to FAB classification لكن WHO إجت عملت
+
+350
+00:29:19,070 --> 00:29:24,070
+classification جديد للـ myelodysplastic syndrome
+
+351
+00:29:24,070 --> 00:29:29,050
+وقالت لأ احنا الأنواع بدنا نقسمها إلى ثمان أنواع
+
+352
+00:29:29,050 --> 00:29:34,090
+مش خمس أنواع زي ما قسموها في الفاب أيش الأنواع؟ هو
+
+353
+00:29:34,090 --> 00:29:37,470
+Refractory Anemia و Refractory Anemia with Ringed
+
+354
+00:29:37,470 --> 00:29:41,010
+Cedroblast ثم Refractory Cytopenia with
+
+355
+00:29:41,010 --> 00:29:45,530
+Multilineage Dysplasia و Refractory Cytopenia with
+
+356
+00:29:45,530 --> 00:29:49,770
+Multilineage Dysplasia and Ringed Cedroblast ثم
+
+357
+00:29:49,770 --> 00:29:53,930
+Refractory Anemia with Excessive Blast 1 و 2 ثم
+
+358
+00:29:53,930 --> 00:29:58,630
+Myelodysplastic Syndrome Unclassified ما له أية ثم
+
+359
+00:29:58,630 --> 00:30:09,430
+Associated with Isolated deletion of 5q. هو يجب أن
+
+360
+00:30:09,430 --> 00:30:12,110
+نقول إن الـ Refractory Anemia مصحوبة عادة
+
+361
+00:30:12,110 --> 00:30:15,730
+بالأنيميا وفي Erythroid dysplasia only، Ringed
+
+362
+00:30:15,730 --> 00:30:19,330
+Cedroblast في أنيميا وفي أكثر من 15% Ringed
+
+363
+00:30:19,330 --> 00:30:22,450
+Cedroblast، Refractory Cytopenia و Multilinear
+
+364
+00:30:22,450 --> 00:30:28,060
+Dysplasia في أي Bad Cytopenia، اثنين. والـ
+
+365
+00:30:28,060 --> 00:30:30,740
+Refractory Cytopenia with Multilinear Dysplasia
+
+366
+00:30:30,740 --> 00:30:34,060
+with Ringed Cedroblast بيكون فيه أكثر من 15%
+
+367
+00:30:34,060 --> 00:30:40,280
+Ringed Cedroblast و Excess Blast 1 بيكون لـ Blast
+
+368
+00:30:40,280 --> 00:30:44,260
+أقل من 5 في الـ blood وأقل من خمسة لتسعة في الـ bone
+
+369
+00:30:44,260 --> 00:30:48,500
+marrow وفي اثنين بيكون من خمسة لتسعة عشر في الـ
+
+370
+00:30:48,500 --> 00:30:51,540
+peripheral blood ومن عشر لتسعة عشر في الـ bone
+
+371
+00:30:51,540 --> 00:30:56,220
+marrow الـ unclassified بيكون فيه cytopenia في الـ
+
+372
+00:30:56,220 --> 00:31:01,320
+blood وفي myeloid أو megakaryocyte dysplasia الـ 5q
+
+373
+00:31:01,320 --> 00:31:07,820
+type بيكون فيه أنيميا و ... و بيكونش
+
+374
+00:31:10,480 --> 00:31:16,300
+أنيميا ولا في زيادة في الـ Platelet لكن بيكون في
+
+375
+00:31:16,300 --> 00:31:21,720
+ميجا كاريوسيتك
+
+376
+00:31:21,720 --> 00:31:28,680
+Cell with high poly related nuclei أو أقل من 5%
+
+377
+00:31:28,680 --> 00:31:34,210
+بالحصة شو اللي بيقابل إشي في WHO مع الرفاق؟ هو الـ
+
+378
+00:31:34,210 --> 00:31:36,790
+Refractory Anemia اللي بيقابلها في الـ WHO
+
+379
+00:31:36,790 --> 00:31:39,690
+Refractory Anemia with Refractory Cytopenia with
+
+380
+00:31:39,690 --> 00:31:44,410
+Multilineage Dysplasia 5q Syndrome Ring Syndrome
+
+381
+00:31:44,410 --> 00:31:53,650
+Blast برضه بيقابلها الرأس و رأس RCMDRS أو الرأس الـ
+
+382
+00:31:53,650 --> 00:31:56,910
+Excessive Blast 1 و 2 Transformation with
+
+383
+00:31:56,910 --> 00:32:02,060
+Multilineage Dysplasia وهي CML وهو myelodysplastic
+
+384
+00:32:02,060 --> 00:32:06,880
+myeloproliferative disease Prognostic group حتى
+
+385
+00:32:06,880 --> 00:32:11,700
+توجه لـ two prognostic group بناء على survival and
+
+386
+00:32:11,700 --> 00:32:17,160
+evolution to acute leukemia تجلب لـ acute leukemia
+
+387
+00:32:17,160 --> 00:32:21,660
+فجاله الجد group الناس اللي بيصير عندهم refractory
+
+388
+00:32:21,660 --> 00:32:25,040
+anemia أو refractory anemia with ring cedroblast
+
+389
+00:32:25,040 --> 00:32:29,370
+أو FAQ بينما الـ Body Group هي الـ Refractory
+
+390
+00:32:29,370 --> 00:32:32,010
+Anemia و Excessive Blast و Excessive Blast in
+
+391
+00:32:32,010 --> 00:32:37,490
+Transformation و CMML وهي طبعا النوع التالت اللي هو
+
+392
+00:32:37,490 --> 00:32:43,070
+الـ Unclassified ممكن يكون في group one ولا group
+
+393
+00:32:43,070 --> 00:32:46,450
+two عنده
+
+394
+00:32:46,450 --> 00:32:51,750
+Prognostic Scoring System يعني قطوا Scores لكل
+
+395
+00:32:51,750 --> 00:32:56,750
+نقطة من المقات وبناء على عدد الـ Scores حددوا
+
+396
+00:32:56,750 --> 00:33:03,430
+الـ prognosis فجأة الـ IPSS بيعتمد على percentage of
+
+397
+00:33:03,430 --> 00:33:08,450
+blast على إذا في كرموزومة abnormality ولا لأ وقداش
+
+398
+00:33:08,450 --> 00:33:13,710
+المريض عنده blood count وهدولة بنحطوا score زي ما
+
+399
+00:33:13,710 --> 00:33:17,570
+قلتلكوا كل ما قل الـ score كل ما كان جيد الـ prognosis
+
+400
+00:33:18,610 --> 00:33:23,590
+فايل بلاست يوم يكون أقل من خمسة بنعطى صفر لكن صار
+
+401
+00:33:23,590 --> 00:33:28,170
+خمسة لعشرة بسبب بياخد نص إذا كان أكثر من هيك بياخد
+
+402
+00:33:28,170 --> 00:33:32,570
+واحد من أحد عشر لعشرين واحد ونصف وهكذا كاريو تايب
+
+403
+00:33:32,570 --> 00:33:37,490
+إذا positive ولا لأ the opinion ماشي إذا من صفر
+
+404
+00:33:37,490 --> 00:33:42,870
+لواحد صفر إذا من اثنين لثلاثة نص وهكذا تجمع هذه
+
+405
+00:33:42,870 --> 00:33:50,100
+الأرقام وكل ما قل الرقم كل ما كان prognosis good
+
+406
+00:33:50,100 --> 00:33:55,080
+differential diagnosis several common diagnostic
+
+407
+00:33:55,080 --> 00:34:02,320
+considerations given these findings طبعا بدك تعمل
+
+408
+00:34:02,320 --> 00:34:06,760
+تستثني عشان تشخص الـ myelodysplasia تشخص تستثني
+
+409
+00:34:06,760 --> 00:34:10,920
+الحالات القاتلة نشوف أسباب الـ Bone Marrow Failure
+
+410
+00:34:10,920 --> 00:34:15,020
+الـ Diabetic أو الـ Drug Induced ونشيلها نشوف إذا
+
+411
+00:34:15,020 --> 00:34:20,260
+في Hypersplenism ولا لا ثم إذا في Vitamin B12 و
+
+412
+00:34:20,260 --> 00:34:25,500
+Folic Acid Deficiency وحالة الـ PNH ممكن يكون
+
+413
+00:34:25,500 --> 00:34:32,120
+عندها Similar Bone Marrow Finding مع الـ MDS طيب
+
+414
+00:34:32,120 --> 00:34:37,250
+كيف نعمل الـ Differentiation بين الـ Acute Non الـ
+
+415
+00:34:37,250 --> 00:34:39,570
+Lymphoblastic Leukemia أو الـ Myelodysplasia
+
+416
+00:34:39,570 --> 00:34:50,050
+ببساطة نعمل القاطع من جهة نجيب نعمل
+
+417
+00:34:50,050 --> 00:34:58,310
+برفرة blood ونشوف
+
+418
+00:34:58,310 --> 00:35:06,150
+نسبة الـ Nucleated Cell نسبة الـ RBCs بالنسبة لـ
+
+419
+00:35:06,150 --> 00:35:11,870
+Nucleated Cell طبعا
+
+420
+00:35:11,870 --> 00:35:14,770
+الـ ... عفوا احنا بنعمل ... ناخذ bone marrow وفي هذه 
+
+421
+00:35:14,770 --> 00:35:17,690
+الـ bone marrow هي اللي بتحدد ناخد bone marrow و
+
+422
+00:35:17,690 --> 00:35:21,430
+بنتطلع عليه بنشوف نسبة الـ RBCs بالنسبة للـ Total
+
+423
+00:35:21,430 --> 00:35:28,370
+Nucleated Cell فإذا كان الـ RBCs .. Nucleated RBCs
+
+424
+00:35:28,370 --> 00:35:33,040
+أكثر من 50% بندور، بنشوف جدّيش فيها Blast ولا إذا الـ
+
+425
+00:35:33,040 --> 00:35:38,400
+BLAST أكثر من 30% بيعنيته لوكيميا ومن نوع M6 وإذا 
+
+426
+00:35:38,400 --> 00:35:43,120
+كان الـ BLAST أقل من 30% بيعنيته MDS للحالة
+
+427
+00:35:43,120 --> 00:35:49,840
+التانية، نشوف نسبة الـ Nucleated RBCs بالنسبة للـ
+
+428
+00:35:49,840 --> 00:35:53,340
+Nucleated Cell إذا أقل من 50%، ندور على جدّيش فيها
+
+429
+00:35:53,340 --> 00:35:57,960
+BLAST ولا إذا الـ BLAST أكثر من 30% بيعنيته
+
+430
+00:35:57,960 --> 00:36:03,950
+لوكيميا لنوع آخر من اللوكيميا غير M6وإذا كان الـ
+
+431
+00:36:03,950 --> 00:36:09,650
+BLAST أقل من 30% فهي MDS وبهيك بنفرق ما بين الـ
+
+432
+00:36:09,650 --> 00:36:12,790
+Acute Non-Lymphoblastic Leukemia و الـ MDS
+
+433
+00:36:12,790 --> 00:36:20,370
+Pathophysiology أهم حاجة أنه ندور على .. نعرف إيش
+
+434
+00:36:20,370 --> 00:36:23,330
+السبب فالـ Initial Hemopoietic Stem Cell Injury هو
+
+435
+00:36:23,330 --> 00:36:28,290
+السبب وطبعا هذه ممكن تكون due to cytotoxic
+
+436
+00:36:28,290 --> 00:36:33,740
+chemotherapy، radiation، viralو chemical exposure
+
+437
+00:36:33,740 --> 00:36:38,080
+or genetic predisposition الكرونية الميوتيشن اللي
+
+438
+00:36:38,080 --> 00:36:45,620
+بتكوّن over the bone marrow طبعا هو اللي بيشكل ال
+
+439
+00:36:45,620 --> 00:36:50,260
+substance الـ healthy stem cell يعني هو اللي بيعيق
+
+440
+00:36:50,260 --> 00:36:56,810
+اللي هو نشاط الـ stem cellبالنسبة للبرفيرال بلد
+
+441
+00:36:56,810 --> 00:37:05,070
+الـ peripheral الـ peripheral
+
+442
+00:37:05,070 --> 00:37:06,710
+الـ peripheral الـ peripheral الـ peripheral الـ peripheral الـ peripheral
+
+443
+00:37:06,710 --> 00:37:07,550
+الـ peripheral الـ peripheral الـ peripheral الـ peripheral الـ peripheral
+
+444
+00:37:07,550 --> 00:37:07,650
+الـ peripheral الـ peripheral الـ peripheral الـ peripheral الـ peripheral
+
+445
+00:37:07,650 --> 00:37:11,410
+الـ peripheral الـ peripheral الـ peripheral الـ peripheral الـ peripheral
+
+446
+00:37:11,410 --> 00:37:15,950
+الـ peripheral الـ peripheral الـ peripheral الـ peripheral الـ peripheral
+
+447
+00:37:15,950 --> 00:37:20,990
+الـ peripheral برضه بنعمل cpc و blood film و بنشوف جدّاش
+
+448
+00:37:20,990 --> 00:37:24,370
+فيه premature RBC فيه عنينيا فيه macrovalocytosis
+
+449
+00:37:24,370 --> 00:37:27,750
+بيسبسه في الـ  stabling  و هكذا كل الـ abnormality
+
+450
+00:37:27,750 --> 00:37:31,470
+الـ erythro dysplasia تشوهات الـ white blood cells برضه
+
+451
+00:37:31,470 --> 00:37:36,390
+بنشوفها و thrombo dysplasia أيضا بتدور على
+
+452
+00:37:36,390 --> 00:37:39,530
+thrombocytopenia و إذا كان فيه large or tertiary
+
+453
+00:37:39,530 --> 00:37:43,340
+platelet هذا الكلام كله في الـ peripheral blood في
+
+454
+00:37:43,340 --> 00:37:44,920
+الـ bone marrow نعمل نفس الحكاية
+
+455
+00:37:44,920 --> 00:37:46,880
+erythrodysplasia, leukodysplasia, and
+
+456
+00:37:46,880 --> 00:37:51,640
+thrombodysplasia وهذا هو الجدول الذي يفرق ما بين
+
+457
+00:37:51,640 --> 00:37:56,700
+اللي هو الـ peripheral blood و الـ bone marrow في
+
+458
+00:37:56,700 --> 00:37:59,700
+الـ myelodysplastic syndrome morphological
+
+459
+00:37:59,700 --> 00:38:08,080
+abnormality of اللي هو الـ peripheral blood and bone
+
+460
+00:38:08,080 --> 00:38:12,130
+marrowفي myelodysplastic syndrome وطبعا بين أنواع
+
+461
+00:38:12,130 --> 00:38:14,670
+مختلفة من الخلايا اللي هي الـ erythroid وميليويد وميكا
+
+462
+00:38:14,670 --> 00:38:18,410
+كاريوسيت و هذا الجدول مش للحفظ لكن ضروري تعرفوا
+
+463
+00:38:18,410 --> 00:38:23,590
+أنه فيه تشوهات وأنواع هذه التشوهات survival time
+
+464
+00:38:23,590 --> 00:38:28,010
+جاله refractory anemia بعيش من سنتين لخمس سنوات
+
+465
+00:38:28,010 --> 00:38:31,230
+with ring syndrome blast زي الـ refractory anemia
+
+466
+00:38:31,230 --> 00:38:36,080
+with excessive blast حوالي عشر شهود وهو نمره اثنين
+
+467
+00:38:36,080 --> 00:38:41,580
+و with excess blast in transformation الـ survival
+
+468
+00:38:41,580 --> 00:38:48,760
+time is six month or less و طبعا هذه الـ median
+
+469
+00:38:48,760 --> 00:38:51,520
+survival time للميلودسبلاستيكس سندرما زي ما أنتم
+
+470
+00:38:51,520 --> 00:38:52,500
+شايفين ده هي
+
+471
+00:38:56,110 --> 00:39:00,750
+النسبة لعدد الأشهر Treatment بيعطوه كيبو ثيرابي و
+
+472
+00:39:00,750 --> 00:39:04,630
+بيعطوه supportive therapy زي الـ white cell PCR بيشيلوا
+
+473
+00:39:04,630 --> 00:39:11,350
+platelet transfusion و في الحالات الصغيرة الشباب
+
+474
+00:39:11,350 --> 00:39:16,590
+يعني بيعملوا bone marrow transplantation يا بيك
+
+475
+00:39:16,590 --> 00:39:21,530
+بنكون أنهينا المحاضرة الـ Milo dysplasia  نتمنى أن
+
+476
+00:39:21,530 --> 00:39:25,550
+تكونوا قد استفدتم و فهمتم و شكرا 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..11c48414b0594b6c045baeab1bf9493cdbcbb098
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_postprocess.srt
@@ -0,0 +1,1904 @@
+1
+00:00:01,570 --> 00:00:07,110
+بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة
+
+2
+00:00:07,110 --> 00:00:15,190
+بعنوان myelodysplastic syndrome وmyelodysplastic
+
+3
+00:00:15,190 --> 00:00:22,060
+syndrome هي عبارة عن مجموعة منالـ Disorders التي
+
+4
+00:00:22,060 --> 00:00:27,640
+تتميز بواحد او اكتر من واحد من ال peripheral blood
+
+5
+00:00:27,640 --> 00:00:30,960
+cytopenia شو يعني peripheral blood cytopenia يعني
+
+6
+00:00:30,960 --> 00:00:37,060
+قلة في one cellular element or more cellular
+
+7
+00:00:37,060 --> 00:00:42,330
+elementand this is reflected in peripheral blood
+
+8
+00:00:42,330 --> 00:00:50,930
+as قلة less in count طبعا هذا الكلام ليه جاله
+
+9
+00:00:50,930 --> 00:00:53,270
+secondary to bone marrow dysfunction لأن ال bone
+
+10
+00:00:53,270 --> 00:00:58,730
+marrow مشتغل صح ببساطة ال bone marrow مابشتغل صح
+
+11
+00:00:58,730 --> 00:01:04,610
+في ال MDS ال bone marrow لا يستطيع ان ينتج خلايا
+
+12
+00:01:04,610 --> 00:01:10,250
+effectively يعني بشكل سليموبالتالي الخلايا التي
+
+13
+00:01:10,250 --> 00:01:13,990
+تتكون هي عبارة عن defective cell بينجوسين هي عبارة
+
+14
+00:01:13,990 --> 00:01:19,610
+عن خلايا مشوهة للخلايا الغير طبيعية الجسم أول بول
+
+15
+00:01:19,610 --> 00:01:24,630
+بقتلها وتقتل من التخلص منها في البومارو أو بعد
+
+16
+00:01:24,630 --> 00:01:28,330
+خروجها في ال peripheral blood سمير بفترة قصيرة
+
+17
+00:01:28,330 --> 00:01:33,210
+محصلة هذا الكلام مدام الخلايا تتكسر محصلة هذا
+
+18
+00:01:33,210 --> 00:01:39,120
+الكلام أنه بيصير في shortage في blood cellوهذا
+
+19
+00:01:39,120 --> 00:01:42,940
+يمكن أن يتم تفكيره بـ No blood count
+
+20
+00:01:42,940 --> 00:01:46,240
+Characteristics
+
+21
+00:01:46,240 --> 00:01:49,560
+كانوا يتميز بالقادة هذا المرض varying degree of
+
+22
+00:01:49,560 --> 00:01:54,940
+trilineal cytopenia تلت أنواع من الخلايا RBCs
+
+23
+00:01:54,940 --> 00:02:01,040
+وHPCs وPlatelets dysplasia تشوهات normocellular or
+
+24
+00:02:01,040 --> 00:02:06,460
+hypercellular pulmonaryوهذه المرضية قد تتطور إلى
+
+25
+00:02:06,460 --> 00:02:11,020
+اكيدلوكيميا ممكن يقلب ببساطة لأكيدلوكيميا
+
+26
+00:02:11,020 --> 00:02:14,860
+Symptoms, Sign and Symptoms طبيعي جدا في بولمارو
+
+27
+00:02:14,860 --> 00:02:20,480
+فاليار فبالتالي في انيميا ونيوتروبينيا وانفكشن
+
+28
+00:02:20,480 --> 00:02:25,760
+فالانيميا is manifested by excessive tiredness
+
+29
+00:02:25,760 --> 00:02:31,040
+shortness of breath pale skin that is correlated
+
+30
+00:02:31,040 --> 00:02:35,790
+with anemiaوهي عبارة عن shortage of RBCs و ال
+
+31
+00:02:35,790 --> 00:02:39,510
+neutropenia او ال infection serious infection مع
+
+32
+00:02:39,510 --> 00:02:44,330
+high fever that also can be caused by leukopenia
+
+33
+00:02:44,330 --> 00:02:50,150
+بمعنى ان مافيش white blood cell كفاية وبالذات ال
+
+34
+00:02:50,150 --> 00:02:58,650
+neutrophil وبالتالي في few mature granulocytes و
+
+35
+00:02:58,650 --> 00:03:03,470
+ال excessive bruising اللي هو ماشية معطبعا بيصير
+
+36
+00:03:03,470 --> 00:03:06,270
+فيه severe nause bleeding او bleeding from the
+
+37
+00:03:06,270 --> 00:03:10,930
+gums that can be due to thrombocytopenia بمعنى انه
+
+38
+00:03:10,930 --> 00:03:16,290
+مافيش بليدلت كفاية في الجسم عشان to plug the holes
+
+39
+00:03:16,290 --> 00:03:21,530
+in damaged blood vessels incidence هذا عبارة عن
+
+40
+00:03:21,530 --> 00:03:24,790
+disease of elderly people median age خمسة وستين
+
+41
+00:03:24,790 --> 00:03:30,850
+سنة اذا كان كان
+
+42
+00:03:30,850 --> 00:03:36,380
+طبعا فيأقل من 10% من الحالات بيكونوا في أقل من 50
+
+43
+00:03:36,380 --> 00:03:42,520
+سنة وبالتالي ال incidence rate بتكون واحد لكل 100
+
+44
+00:03:42,520 --> 00:03:49,820
+ألف في ال population لكنها تزيد إلى واحد لكل ألف
+
+45
+00:03:49,820 --> 00:03:53,900
+من ال population في الأعمار الكبيرة اللي هي أكبر
+
+46
+00:03:53,900 --> 00:03:58,360
+من 60 سنة وال male is slightly higher than female
+
+47
+00:03:59,910 --> 00:04:04,490
+أسباب حطوا سببين لهذا الموضوع كانوا فيه نوعين من
+
+48
+00:04:04,490 --> 00:04:09,330
+ال MDS نوع بيسموه de novo اللي هو الأصلي الأساسي
+
+49
+00:04:09,330 --> 00:04:11,930
+واللي غالبا associated with benzene exposure
+
+50
+00:04:11,930 --> 00:04:16,410
+cigarette smoker and viruses وفي نوع منه
+
+51
+00:04:16,410 --> 00:04:20,830
+congenital بيسموه Fanconi's anemia نوع من ال
+
+52
+00:04:20,830 --> 00:04:25,010
+congenital disease بيسموها Fanconi's anemia sorry
+
+53
+00:04:25,010 --> 00:04:29,810
+هذا plastic anemiaالنوع التاني هو therapy related
+
+54
+00:04:29,810 --> 00:04:32,970
+و therapy induced and usually associated with
+
+55
+00:04:32,970 --> 00:04:37,270
+alkalizing agent chemotherapy or radiation بيحصل
+
+56
+00:04:37,270 --> 00:04:42,970
+نتيجة أخذ المريض هذه الكمياء دي لحالات هذه المواد
+
+57
+00:04:42,970 --> 00:04:49,030
+الكيموية و هذه العلاجات بيصير في عنده MDS هذه صورة
+
+58
+00:04:49,030 --> 00:04:55,170
+جيدة جدا بتودحنا أو بتفهمنا بالظبط أنواع اللي هو
+
+59
+00:04:55,850 --> 00:04:59,790
+الـ hematological ماليجنازي إذا فهمناها بنفهم
+
+60
+00:04:59,790 --> 00:05:06,750
+بنقدر نعرف تقسمتها فلأنه بيوضح اللي هو أضرع أو
+
+61
+00:05:06,750 --> 00:05:13,350
+ذراعي ال hemapoiesis كنا بنعرف أن ال stem cell ب
+
+62
+00:05:13,350 --> 00:05:18,750
+.. كان proliferate يعني الذراعين المطلوبين
+
+63
+00:05:18,750 --> 00:05:22,610
+proliferation و differentiation ماشي
+
+64
+00:05:25,890 --> 00:05:32,110
+ففي الـ MDS الخلل يكون في الـ differentiation
+
+65
+00:05:32,110 --> 00:05:37,590
+فبالتالي المحص لإيش؟ هي this plastic form of cell
+
+66
+00:05:37,590 --> 00:05:43,710
+وبما أن الخلل في كل أنواع الخلايا يبقى بيصير فيه
+
+67
+00:05:43,710 --> 00:05:49,650
+tri lineage cytopenia بينما لو كان الخلل في ذراع
+
+68
+00:05:49,650 --> 00:05:53,550
+ال proliferationبتعمل مرض بيسموه اللي هو Non
+
+69
+00:05:53,550 --> 00:05:58,790
+Leukemic Proliferative Disease و لو كان الخلل في
+
+70
+00:05:58,790 --> 00:06:05,650
+الذراعين إضافة إلى dominant of mutant type يعني في
+
+71
+00:06:05,650 --> 00:06:11,230
+prominent cell type which
+
+72
+00:06:11,230 --> 00:06:15,050
+is dominant بيتكون
+
+73
+00:06:15,050 --> 00:06:18,970
+الحالة Leukemia يمكن في ال Leukemia الذراعين
+
+74
+00:06:18,970 --> 00:06:31,500
+مضربينوهي فيه mutant agents في ال MDS الذراع ال
+
+75
+00:06:31,500 --> 00:06:34,880
+differentiation بيكون مضروب في ال non-logistic
+
+76
+00:06:34,880 --> 00:06:38,440
+proliferative disorders ال proliferation بيكون
+
+77
+00:06:38,440 --> 00:06:39,420
+مضروب
+
+78
+00:06:41,880 --> 00:06:45,460
+طبعا الـ Ethological agents عنده قائمة طويلة عريضة
+
+79
+00:06:45,460 --> 00:06:49,480
+جدا ممكن تكون سبب لهذه الأمراض على هذا المرض زي ال
+
+80
+00:06:49,480 --> 00:06:52,000
+tobacco, ionizing radiation, organic chemical
+
+81
+00:06:52,000 --> 00:06:57,180
+بأنواعها heavy metal, herbicides و pesticides و
+
+82
+00:06:57,180 --> 00:07:00,980
+fertilizers بجموعة كثيرة من ال calculating agent و
+
+83
+00:07:00,980 --> 00:07:07,340
+petroleum و هكذا طبعا هذا محصلته كرمزوم ال
+
+84
+00:07:07,340 --> 00:07:11,060
+abnormality وسجلت حالات كرمزوم ال abnormalityفي
+
+85
+00:07:11,060 --> 00:07:15,380
+أكتر من خمسين فمية من الدنوبة وفي حوالي كل حالات
+
+86
+00:07:15,380 --> 00:07:21,580
+ال secondary أو ال therapy related MDS طبعا هذه
+
+87
+00:07:21,580 --> 00:07:26,700
+عبارة عن أمثلة فقط لحالات ال chromosome ال
+
+88
+00:07:26,700 --> 00:07:30,660
+abnormality اللي بتتصاحب أو بتكون موجودة في ال MDS
+
+89
+00:07:30,660 --> 00:07:37,120
+فهي زي ما انتوا شايفين five U minus ماشي seven
+
+90
+00:07:37,120 --> 00:07:45,490
+elevenمنظومي سمن وكذا عدد كثيرة من كرومزومة ال
+
+91
+00:07:45,490 --> 00:07:48,550
+abnormality طبعا من أشهرها deletion of the long
+
+92
+00:07:48,550 --> 00:07:57,010
+arm of chromosome 5 5Q minus syndrome and حتى
+
+93
+00:07:57,010 --> 00:08:06,490
+اليوم في يعني نوع اسمه 5Q minus syndrome or 5Q
+
+94
+00:08:06,490 --> 00:08:12,800
+minus MDSهو مرتبط بشكل كبير بـRheumatoid with
+
+95
+00:08:12,800 --> 00:08:14,580
+refractory anemia
+
+96
+00:08:18,460 --> 00:08:22,520
+وبيشكل حوالي 70% هذا الـ Cytogenetic abnormality
+
+97
+00:08:22,520 --> 00:08:27,520
+of this type طبعا في منطقة الـ Q arm of chromosome
+
+98
+00:08:27,520 --> 00:08:32,220
+number 7 وجدوا انه في معظم الجينات اللي مسؤول عنهم
+
+99
+00:08:32,220 --> 00:08:35,980
+weight and growth factor وبالتالي غيابها معناته
+
+100
+00:08:35,980 --> 00:08:40,440
+مافيش growth factor زي IL 3 أو 4 أو 5 أو GM CSF و
+
+101
+00:08:40,440 --> 00:08:46,190
+MCSF وبالتالي ال receptorأيضًا كمان غايب لأن هو
+
+102
+00:08:46,190 --> 00:08:50,090
+gene and receptor growth factor and their receptor
+
+103
+00:08:50,090 --> 00:08:55,910
+وبالتالي طبعًا فقدر هذه المواد هيأدى الى
+
+104
+00:08:55,910 --> 00:09:01,810
+disruption or overdraft of overdraft hemopoiesis
+
+105
+00:09:01,810 --> 00:09:09,190
+monosomy 7 and 7q- أيضًا associated with secondary
+
+106
+00:09:09,190 --> 00:09:16,490
+MDS ويجروا في هذه المنطقةفي الـ major surface
+
+107
+00:09:16,490 --> 00:09:23,750
+glycoprotein 130 وبالتالي غيابه معناته في غياب لـ
+
+108
+00:09:23,750 --> 00:09:26,710
+neutrophil function and susceptibility to
+
+109
+00:09:26,710 --> 00:09:29,930
+bacterial infection غالبا لإن
+
+110
+00:09:29,930 --> 00:09:34,870
+الجرانيلوسيتمولوسيتكموتاكتك activity is defected
+
+111
+00:09:34,870 --> 00:09:39,310
+11Q- deletion of 11Q
+
+112
+00:09:41,750 --> 00:09:46,730
+شكل هذا حوالي عشرين فمية من حالات الراس Refractory
+
+113
+00:09:46,730 --> 00:09:50,630
+أنيمة with ringed cedroblast و لسه abnormality
+
+114
+00:09:50,630 --> 00:09:55,030
+غالبا associated with raised iron stores تلاقي ال
+
+115
+00:09:55,030 --> 00:09:58,250
+iron stores عالية و يصير فيها ringed cedroblast
+
+116
+00:09:58,250 --> 00:10:06,030
+السبب في ذلك وجود الجين المسؤول عن ال H subunit of
+
+117
+00:10:06,030 --> 00:10:12,510
+ferritinفي هذه المنطقة وعلى كرمزوم رقم 11 وذلك
+
+118
+00:10:12,510 --> 00:10:21,150
+ايضا ما يفسر زيادة iron store abnormality في
+
+119
+00:10:21,150 --> 00:10:28,830
+كرمزوم 17 طبعا a inversion of 17Q قالوا في هذه
+
+120
+00:10:28,830 --> 00:10:35,310
+المنطقة يوجد ال B53 او tumor saprosargen اللى
+
+121
+00:10:35,310 --> 00:10:42,420
+موجود في كثير من الحلات من الو بالذات
+
+122
+00:10:42,420 --> 00:10:46,520
+لما تجلب ل البلاستيك من ال plastic phase من ال
+
+123
+00:10:46,520 --> 00:10:53,480
+chronic phase ل البلاستيك phase و تقريبا حوالي 5%
+
+124
+00:10:53,480 --> 00:11:03,680
+من الحالات of primary MDS طبعا هذا بيدي الى this
+
+125
+00:11:03,680 --> 00:11:06,660
+plastic feature of cells and neutrophil
+
+126
+00:11:06,660 --> 00:11:13,510
+vacculationأب نورمالتي في كرمزوم تلاتة بعمل ميجا
+
+127
+00:11:13,510 --> 00:11:20,210
+كاريوبيسيس وthrombocytosis وهذا غالبا مصحوب بهذا
+
+128
+00:11:20,210 --> 00:11:25,230
+الاب نورمالتي طيب شوف ايديت importance of
+
+129
+00:11:25,230 --> 00:11:28,670
+indication of كرمزوم الاب نورمالتي يقول نمرة واحد
+
+130
+00:11:28,670 --> 00:11:32,270
+to confirm diagnosis نمرة اتنين to know the stage
+
+131
+00:11:32,270 --> 00:11:36,090
+of disease نمرة تلاتة to know the direction of
+
+132
+00:11:36,090 --> 00:11:41,420
+progression of diseaseتطور الحالة المرضية نمرة
+
+133
+00:11:41,420 --> 00:11:45,440
+أربع Multiple Genetic Abnormality معناته المريض في
+
+134
+00:11:45,440 --> 00:11:53,760
+مراحله المتأخرة Pattern of MDS Evolution كيف يتكون
+
+135
+00:11:53,760 --> 00:11:59,340
+هذا المرض و مراحل تكونه جابوا يبدأ ب stable group
+
+136
+00:11:59,340 --> 00:12:02,840
+with no increase in bone marrow blast
+
+137
+00:12:08,420 --> 00:12:10,240
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+138
+00:12:10,240 --> 00:12:16,340
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+139
+00:12:16,340 --> 00:12:19,840
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+140
+00:12:19,840 --> 00:12:20,040
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+141
+00:12:20,040 --> 00:12:20,660
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+142
+00:12:20,660 --> 00:12:23,100
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+143
+00:12:23,100 --> 00:12:27,720
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+144
+00:12:27,720 --> 00:12:33,370
+مضروبة ولكن مستقو .. نمرة تلاتة بيصير في زيادة في
+
+145
+00:12:33,370 --> 00:12:38,630
+ال blast count و .. طبعا حتى في غياب ال
+
+146
+00:12:38,630 --> 00:12:43,310
+cytogenetic changes و هدا هي المراحل المختلفة ده
+
+147
+00:12:43,310 --> 00:12:47,370
+هي normal stem cell لكنها تعرضت ل insult و من ال
+
+148
+00:12:47,370 --> 00:12:51,610
+insult genetic insult ممكن يكون age or viral or
+
+149
+00:12:51,610 --> 00:12:58,690
+chemical or radiochemicalماذا يحصل؟ يحصل فيه
+
+150
+00:12:58,690 --> 00:13:02,910
+Stable New Abnormal Clone Clue abnormal لكنها
+
+151
+00:13:02,910 --> 00:13:05,990
+مازالة مستقلة يعني المريض في هذا الحالة بيكون
+
+152
+00:13:05,990 --> 00:13:12,090
+hematologically silent إذا اتعرض الجينات للـ
+
+153
+00:13:12,090 --> 00:13:16,550
+mutation يحصل في growth advantage و يدخل المريض في
+
+154
+00:13:16,550 --> 00:13:20,420
+مرحلة بيسموها pre-leukemic statusلو فحصنا ال
+
+155
+00:13:20,420 --> 00:13:24,220
+career-type في هذه المرحلة بيلاقيها abnormal يعني
+
+156
+00:13:24,220 --> 00:13:27,740
+قبل هيك بيكون normal او نعم قبل هيك بيكون normal
+
+157
+00:13:27,740 --> 00:13:33,720
+طبعا once career-type is abnormal يعني فيه
+
+158
+00:13:33,720 --> 00:13:36,720
+chromosomal abnormality بيصير فيه inhibition
+
+159
+00:13:36,720 --> 00:13:41,920
+لnormal hemopoiesis وتنتهي غالبا منها بتجلب لمين؟
+
+160
+00:13:41,920 --> 00:13:45,360
+للوكيميا بتجلب للوكيميا بيصير في فلان لوكيميا
+
+161
+00:13:45,360 --> 00:13:50,320
+clone is producedيبقى هذه هي المراحل المختلفة
+
+162
+00:13:50,320 --> 00:13:54,920
+Normal stem cell تعرضت ل install تكوين new
+
+163
+00:13:54,920 --> 00:13:58,580
+abnormal clone لو فحصنا ال proto-oncogen او ال
+
+164
+00:13:58,580 --> 00:14:02,820
+جينات بيكون by karyotyping sorry لكروميزومات by
+
+165
+00:14:02,820 --> 00:14:05,860
+karyotyping بتكون normal ومافي blast cell في هذه
+
+166
+00:14:05,860 --> 00:14:09,300
+الحالة لكن once a mutation is occurred بيصير في
+
+167
+00:14:09,300 --> 00:14:12,960
+growth advantage بيخش المريض في prolaconic status
+
+168
+00:14:12,960 --> 00:14:16,690
+لو فحصنا ال karyotyping على جهة abnormalمتى ما
+
+169
+00:14:16,690 --> 00:14:19,870
+صارت abnormal يعني فيه نهبش لnormal hemopoiesis
+
+170
+00:14:19,870 --> 00:14:25,550
+يعني اللي في الغالب تجلب للوكيميا classification
+
+171
+00:14:25,550 --> 00:14:30,910
+of FAP قسموها إلى خمس أنواع مختلفة هذا الجدول
+
+172
+00:14:30,910 --> 00:14:35,470
+بلخصنا الأنواع المختلفة كلها اللي ان شاء الله
+
+173
+00:14:35,470 --> 00:14:40,310
+بنجيها بالتفصيل قدامي بس هذا الجدول مهم ماشي ايش
+
+174
+00:14:40,310 --> 00:14:43,860
+بيقولالانواع هي خمس انواع Refractory Anemia
+
+175
+00:14:43,860 --> 00:14:46,180
+Refractory Anemia with Ringed Cedroplast
+
+176
+00:14:46,180 --> 00:14:48,800
+Refractory Anemia with Excessive Lust هاي
+
+177
+00:14:48,800 --> 00:14:51,780
+الإختصارات Refractory Anemia with Excessive Lust
+
+178
+00:14:51,780 --> 00:14:52,700
+and Transformation Refractory Anemia with
+
+179
+00:14:52,700 --> 00:14:53,860
+Excessive Lust and Transformation and Chronic
+
+180
+00:14:53,860 --> 00:14:55,400
+Myelomonasitic Leukemia
+
+181
+00:15:04,420 --> 00:15:08,400
+نقدر نشوف الـ Blast في الـ Peripheral Blood و الـ
+
+182
+00:15:08,400 --> 00:15:11,580
+Bone Marrow ثم نشوف الـ Monocytes لإنه في النوع
+
+183
+00:15:11,580 --> 00:15:16,160
+فيه الـ Monocytes ثم Ringed Cedroblast لإنه في
+
+184
+00:15:16,160 --> 00:15:19,560
+النوع بيصير فيه Ringed Cedroblast و نشوف إذا كان
+
+185
+00:15:19,560 --> 00:15:24,000
+فيه other features can be compared فالـ Refractor
+
+186
+00:15:24,000 --> 00:15:26,560
+يقول إن الـ Blast في ال Peripheral Blood يكون أقل
+
+187
+00:15:26,560 --> 00:15:29,580
+من واحد في ال Bone Marrow أقل من خمسة و أنا واحدة
+
+188
+00:15:29,580 --> 00:15:35,750
+عبارة عن Normal Percentageالمنوسية اقل من واحد ال
+
+189
+00:15:35,750 --> 00:15:40,090
+ringcedroblast بتكون اقل من خمستاش و يكون المريض
+
+190
+00:15:40,090 --> 00:15:44,870
+عنده أنيميا انها اللي associated with يعني اللي
+
+191
+00:15:44,870 --> 00:15:48,910
+بيشبهه او تطوره اللي هو النوع التاني اللي هو
+
+192
+00:15:48,910 --> 00:15:53,100
+refractory anemia و ringcedroblastالـ blast يكون
+
+193
+00:15:53,100 --> 00:15:55,720
+أقل من واحد في الـ peripheral blood و أقل من خمسة
+
+194
+00:15:55,720 --> 00:15:59,840
+في البومارو يعني still ال blast لم يتكوّن مانوسايت
+
+195
+00:15:59,840 --> 00:16:05,360
+أيضا كذلك لكن اللي بيميزها وجود ringed cedroblast
+
+196
+00:16:05,360 --> 00:16:09,980
+اسمها with ringed cedroblast ماشي؟ يعني في زيادة
+
+197
+00:16:09,980 --> 00:16:15,340
+في إيش؟ في ال ironهو طبعا في هذا الحالة بيكون في
+
+198
+00:16:15,340 --> 00:16:22,800
+Anemia وفي Refractory Cytopenia لشي بتدي علاج لا
+
+199
+00:16:22,800 --> 00:16:27,740
+يستجيب Refractory Anemia وExcessive Blast هي بدت
+
+200
+00:16:27,740 --> 00:16:31,160
+تزيد ال blast يعني أقل من خمسة في ال peripheral
+
+201
+00:16:31,160 --> 00:16:35,880
+blood من خمسة لعشرين في ال bone marrow يعني لسه
+
+202
+00:16:35,880 --> 00:16:40,280
+ماوصل لتلاتين مايقدرش نسميه leukemia وأقل من واحد
+
+203
+00:16:40,280 --> 00:16:45,440
+ال monocyte أقل من خمستاشراللي هو الـ Sidroblast و
+
+204
+00:16:45,440 --> 00:16:49,960
+الانيم .. و ال .. ال .. طبعا ال other feature اللي
+
+205
+00:16:49,960 --> 00:16:54,000
+هو Cytopenia و Refractory Anemia و الشغلات هذه
+
+206
+00:16:54,000 --> 00:16:58,640
+المواحد الرابع اللي هو Refractory Anemia و Excess
+
+207
+00:16:58,640 --> 00:17:03,780
+Blast in Transformation إيش يعني؟ بدت تقلب فشوفنا
+
+208
+00:17:03,780 --> 00:17:08,250
+ال blast في ال preferable أكتر من خمسةبعد تجربة
+
+209
+00:17:08,250 --> 00:17:12,590
+البرمارو من عشرين لثلاثين يعني تقريبا لكيميا
+
+210
+00:17:12,590 --> 00:17:17,650
+تقريبا في طريقة إلى اللوكيميا يعني خلاص بدأت تجلب
+
+211
+00:17:17,650 --> 00:17:22,450
+in transformation المنو سايت أقل من واحد ring cell
+
+212
+00:17:22,450 --> 00:17:27,110
+plus أقل من خمسة ونبدأ نشوف our body in plus cell
+
+213
+00:17:27,110 --> 00:17:35,360
+وفي زيادة في ال granulocyte countللـ Granulocyte
+
+214
+00:17:35,360 --> 00:17:40,860
+والبرو وطبعا بشكل أساسي Chronic Myelomonasetic
+
+215
+00:17:40,860 --> 00:17:44,880
+leukemia البلاستقال من خمسة ال .. في ال peripheral
+
+216
+00:17:44,880 --> 00:17:49,860
+blood اقل من عشرين في البوماروم و اكتر من واحد لأن
+
+217
+00:17:49,860 --> 00:17:54,940
+هذا هو العامل اللي بيخصها يعني اكتر من الف
+
+218
+00:17:54,940 --> 00:18:01,560
+monocytes في ال peripheral blood وأقل من 15 Ringed
+
+219
+00:18:01,560 --> 00:18:06,160
+Cedroblast وفي زيادة لبرومونو سايتز هذا جدول
+
+220
+00:18:06,160 --> 00:18:09,280
+تقريبا بودح لي الأنواع المختلفة واللي ان شاء الله
+
+221
+00:18:09,280 --> 00:18:14,020
+هنجي إليها دايما بالتفصيل واحد ورا التانية وأول
+
+222
+00:18:14,020 --> 00:18:17,500
+هذي الأنواع اللي هو Refractory Anemia قلنا بيصير
+
+223
+00:18:17,500 --> 00:18:21,300
+فيها by definition dysplasia للارثرويد series only
+
+224
+00:18:21,300 --> 00:18:25,400
+clinically في أنيميا which is refractory to
+
+225
+00:18:25,400 --> 00:18:29,590
+treatment تديها كل المقويات لاستجيب للعلاجميرو
+
+226
+00:18:29,590 --> 00:18:32,790
+بلاستقال من واحد في البريفيرالبلاد وقال من خمسة في
+
+227
+00:18:32,790 --> 00:18:37,190
+البرومارو ومافيش صدروا بلاستقال من خمستاشر ومافيش
+
+228
+00:18:37,190 --> 00:18:42,970
+our root body وكانوا you have to exclude other
+
+229
+00:18:42,970 --> 00:18:50,610
+ideological agents ايش يعني؟ اي أسباب أخرى بتعمل
+
+230
+00:18:50,610 --> 00:18:55,770
+هذه الصورة لازم تستثنيها منها drug or toxin
+
+231
+00:18:55,770 --> 00:18:59,650
+exploderViral Infection, Vitamin Deficiency,
+
+232
+00:19:00,110 --> 00:19:04,090
+Congenital Disease استثناء هذه الشغلات ضد الـ
+
+233
+00:19:04,090 --> 00:19:09,830
+Refractory Anemia هي التشخيص الدنيا تجهي من خمسة
+
+234
+00:19:09,830 --> 00:19:14,190
+لعشر حالات في عشرة في المية من الـ MDS وهي بصيب
+
+235
+00:19:14,190 --> 00:19:18,230
+الإختيارية morphologically بنشوف أنيزو بويكيلو
+
+236
+00:19:18,230 --> 00:19:24,310
+سايتوسز في البرفرالسمين وفي dyserythropoiesis with
+
+237
+00:19:24,310 --> 00:19:28,650
+nuclear abnormalityبنشوف أشهر حاجة ميجالو
+
+238
+00:19:28,650 --> 00:19:33,830
+بلاستويدية changes ميجالو كبير بلاستويد من بلاست
+
+239
+00:19:33,830 --> 00:19:40,390
+ماشي يعني immature changes وهي أقل من 15% ringed
+
+240
+00:19:40,390 --> 00:19:46,850
+cedroblast جناتكس 25% may have genetic abnormality
+
+241
+00:19:46,850 --> 00:19:50,190
+وليه ال diagnosis قالوا بيعيش ال median survival
+
+242
+00:19:50,920 --> 00:19:57,460
+time حوالي 66 شهر لكن 6% منهم بيجلبوا ل acute
+
+243
+00:19:57,460 --> 00:20:02,840
+leukemia بيتطور المرض عندهم to acute leukemia وهذا
+
+244
+00:20:02,840 --> 00:20:08,100
+البرفر السمير أي أنيزو بويكيلو سايتوسي طبعا
+
+245
+00:20:08,100 --> 00:20:10,920
+الانيزو سايتوسي اختلاف الحجوم بويكيلو سايتوسي
+
+246
+00:20:10,920 --> 00:20:15,840
+اختلاف الأشكال وتخيلوا ال bone marrow شايفين كيف
+
+247
+00:20:15,840 --> 00:20:21,900
+الخلايا تتكسر حتى في ال bone marrowوهي بتكون خلايا
+
+248
+00:20:21,900 --> 00:20:26,240
+مشوّة معظم الخلايا اللي موجودة هي عبارة عن خلايا
+
+249
+00:20:26,240 --> 00:20:32,280
+مشوّة وهي ميجالو بلاستويد الـchanges كبيرة لمن؟
+
+250
+00:20:32,280 --> 00:20:41,440
+للخلايا الـRBCs ميجالو بلاستويد تكبر كتير المرة
+
+251
+00:20:41,440 --> 00:20:43,820
+التانية الـrefractor يعني ماهو الـRing سيدروبلاست
+
+252
+00:20:43,820 --> 00:20:46,480
+وهذا بيصير فيه display
+
+253
+00:20:49,160 --> 00:20:52,060
+Clinically, anemia is refractory to hematinic
+
+254
+00:20:52,060 --> 00:20:56,080
+therapy زي الأولاني و نفس الحكاية ال myeloplast في
+
+255
+00:20:56,080 --> 00:20:59,320
+ال preferable blood أقل من خمسة و في ال bone
+
+256
+00:20:59,320 --> 00:21:03,540
+marrow أقل من واحد و أقل من خمسة في ال bone marrow
+
+257
+00:21:03,540 --> 00:21:07,760
+فى شرينج سيدروبلاست وفى شاورو د بادي لكن you have
+
+258
+00:21:07,760 --> 00:21:12,540
+to exclude antituberculosis drug والالكولازيم
+
+259
+00:21:12,540 --> 00:21:16,220
+الدمونولوجي من عشر او اتناش في المية من ال MDS
+
+260
+00:21:16,220 --> 00:21:19,700
+حالات ال MDSو بيسيب الاختيارية و ال males أكتر من
+
+261
+00:21:19,700 --> 00:21:22,700
+ال females و morphologically بنشوف pattern
+
+262
+00:21:22,700 --> 00:21:27,460
+diamorphic يعني شكلين يعني الخلايا لها شكلين on
+
+263
+00:21:27,460 --> 00:21:32,740
+peripheral smears معظم ال RBCs normochromic لكن في
+
+264
+00:21:32,740 --> 00:21:38,340
+second population وهو hypochromic طبعا في this
+
+265
+00:21:38,340 --> 00:21:42,140
+يعني abnormal erythropoiesis في nuclear
+
+266
+00:21:42,140 --> 00:21:46,460
+abnormalities و بنشوف الميجالو blastoid changes
+
+267
+00:21:48,130 --> 00:21:54,430
+مفروض يقل من 15% Ringcedroblast الـ Ringcedroblast
+
+268
+00:21:54,430 --> 00:21:58,130
+هي عبارة عن إيراثرويد الـ precursor cell فيها أكتر
+
+269
+00:21:58,130 --> 00:22:05,170
+من عشرة Sidrotic granules وهذه Sidrotic granules
+
+270
+00:22:05,170 --> 00:22:12,730
+in circling تقريبا تلت أو أكتر من تلت أنواع if
+
+271
+00:22:12,730 --> 00:22:21,080
+excess blast presencethis dictate diagnosis حتى
+
+272
+00:22:21,080 --> 00:22:27,740
+بالرغم من ال percentage of ringed cedroblast ماشي
+
+273
+00:22:27,740 --> 00:22:32,700
+بغض النظر عن وجود ال ringed cedroblast اذا شفنا ال
+
+274
+00:22:32,700 --> 00:22:37,360
+ringed cedroblast اذا شفنا ال blast موجودة هذا على
+
+275
+00:22:37,360 --> 00:22:43,500
+طول بيخلنا نفكر في اتجاه اخر genetically
+
+276
+00:22:45,410 --> 00:22:48,710
+في كلونة او كرمزومة ال abnormality اقل من 10% من
+
+277
+00:22:48,710 --> 00:22:53,550
+الحالات develop such abnormality وبالتالي you have
+
+278
+00:22:53,550 --> 00:22:58,830
+to reassess their diagnoses ال median survival
+
+279
+00:22:58,830 --> 00:23:07,010
+time ست سنوات و 72 شهر و 1-2% من الحالات بيجلب ل
+
+280
+00:23:07,010 --> 00:23:13,170
+acute leukemia و هي ال biomorphic شايفين الشكلين
+
+281
+00:23:13,760 --> 00:23:22,680
+اللي موجودين لل RBCs وهي Ringed Cedroplast كما
+
+282
+00:23:22,680 --> 00:23:27,860
+تشايفين هي Ringed Cedroplast اكتر من تلت الخضية is
+
+283
+00:23:27,860 --> 00:23:34,520
+ringed by cedrotic body وهذا هي Ringed Cedroplast
+
+284
+00:23:36,170 --> 00:23:39,870
+هو الـ megaloblastoid الاختلافات التي نشاهدها في
+
+285
+00:23:39,870 --> 00:23:45,370
+الـ RBC's تكبر و نيكلياسها غير طبيعية و كل شيء
+
+286
+00:23:45,370 --> 00:23:52,250
+فيها غير طبيعي نوع التالت reflector يعني ما with
+
+287
+00:23:52,250 --> 00:23:59,170
+excessive blast ياله by definition هذافي بيكون
+
+288
+00:23:59,170 --> 00:24:03,750
+خمسة لتسعة تاش في المية من ال myeloplast present
+
+289
+00:24:03,750 --> 00:24:07,570
+في ال bone marrow قسموها لنوعين قالوا إذا ال blast
+
+290
+00:24:07,570 --> 00:24:12,590
+من خمسة لتسعة في المية في ال bone marrowوأقل من
+
+291
+00:24:12,590 --> 00:24:15,890
+خمسة في ال blood بيسموها Refractory Anemothesis
+
+292
+00:24:15,890 --> 00:24:20,930
+Blast I وإذا ال blast أقل من عشرة لتسعة عاشر في
+
+293
+00:24:20,930 --> 00:24:25,590
+المية في ال bone marrow وفي أول root body بيسموها
+
+294
+00:24:25,590 --> 00:24:32,510
+Refractory Anemothesis Blast II الدينالوجيا بشكل
+
+295
+00:24:32,510 --> 00:24:36,570
+أربعين في المية من حالات ال MDS بتجيب الاختيارية و
+
+296
+00:24:36,570 --> 00:24:42,800
+morphologicallyفي Dysplasia في كل أنواع الخلايا في
+
+297
+00:24:42,800 --> 00:24:49,380
+نتروفيل أبنرمالتي التي قد تشمل Hypogranulation
+
+298
+00:24:49,380 --> 00:24:55,180
+Hypersegmentation سودو بالكرهوت Anomaly اللي هو
+
+299
+00:24:55,180 --> 00:24:59,740
+عبارة عن Hypersegmentation مع بار بال shape
+
+300
+00:24:59,740 --> 00:25:03,620
+للنكلياس
+
+301
+00:25:03,620 --> 00:25:08,050
+بعدين سودو تشيديا كيجاشي Granulesفي abnormality
+
+302
+00:25:08,050 --> 00:25:11,130
+filigranous of neutrophil ميجا كاريوسايت
+
+303
+00:25:11,130 --> 00:25:14,970
+abnormality ممكن نشوف hybolobulation وممكن نشوف
+
+304
+00:25:14,970 --> 00:25:21,770
+micro ميجا كاريوسايت في هذا النوع ال morphology
+
+305
+00:25:21,770 --> 00:25:26,210
+erythroid glucosal abnormality ممكن نشوف فيها
+
+306
+00:25:26,210 --> 00:25:29,270
+abnormal lobulation ميجا أروبلاستويد and
+
+307
+00:25:29,270 --> 00:25:35,390
+multinucleation وإذا كان الورنة ال myeloblast ممكن
+
+308
+00:25:35,390 --> 00:25:40,870
+تكون من 0 ل19فى ال blood او من خمسة لتسعة عشر فى
+
+309
+00:25:40,870 --> 00:25:46,530
+البورمارو غالبا ال بورمارو is hypercellular فقط
+
+310
+00:25:46,530 --> 00:25:50,110
+عشر لخمستاشر فالمية hypercellular وفى abnormal
+
+311
+00:25:50,110 --> 00:25:55,410
+localization of immature بكاسر اللى هو abnormal
+
+312
+00:25:55,410 --> 00:26:02,780
+localization of immatureprecursor cell may be
+
+313
+00:26:02,780 --> 00:26:07,500
+present المهم في ان خلايا بيكون عصرتها سنة ستاشر
+
+314
+00:26:07,500 --> 00:26:14,640
+تقسيدي تلاتاشر تلاتة و تلاتين ميو سبعتار و النوع
+
+315
+00:26:14,640 --> 00:26:20,480
+الوحيد من ال من ال myelodysplastic syndrome which
+
+316
+00:26:20,480 --> 00:26:27,580
+have relevant phenotype category
+
+317
+00:26:27,580 --> 00:26:33,440
+يعنيGenetic طبعا سجلت حالات كثيرة منها كرموزومة
+
+318
+00:26:33,440 --> 00:26:36,820
+لأبنورماليتي من تلاتين لخمسين في المائة من الحالات
+
+319
+00:26:36,820 --> 00:26:42,540
+Prognosis median survival time لtype one طبعا تاشر
+
+320
+00:26:42,540 --> 00:26:47,480
+شهر وtype two عشر أشهر وخمسة وعشرين في المائة من
+
+321
+00:26:47,480 --> 00:26:50,520
+حالات type one تجلب لالوكيميا بينما تلاتة و تلاتين
+
+322
+00:26:50,520 --> 00:26:56,020
+في المائة من اللي هو type two بجلب لالوكيميا وهي
+
+323
+00:26:56,020 --> 00:27:00,690
+ال hypercellular bone marrow مليان خلائياوهي الـ
+
+324
+00:27:00,690 --> 00:27:08,170
+Blast and hypogranulation اللي موجود وهي
+
+325
+00:27:08,170 --> 00:27:13,210
+ال megaloblastoid اللي ملاحظها with our sorry
+
+326
+00:27:13,210 --> 00:27:16,530
+myeloblast with our root body لإنه بنتحكي على
+
+327
+00:27:16,530 --> 00:27:21,390
+blast the excess blast وهي فيه vacuoles في ال
+
+328
+00:27:21,390 --> 00:27:25,830
+cytoblasm وهي كل ال abnormality بتاعة ال
+
+329
+00:27:25,830 --> 00:27:31,980
+neutrophilسواء كانت Shiryak-Higashi بأنواع مختلفة
+
+330
+00:27:31,980 --> 00:27:35,300
+آخر هذه الأنواع اللي هو Refractory Anemia with
+
+331
+00:27:35,300 --> 00:27:40,660
+excess blast in transformation بشكل
+
+332
+00:27:40,660 --> 00:27:47,960
+21 ل 30% من حالات اللي هو sorry في 21 ل 30% من ال
+
+333
+00:27:47,960 --> 00:27:52,620
+blast في البولمارو و أكتر من 5% blast في ال
+
+334
+00:27:52,620 --> 00:27:56,520
+peripheral blood و في excessive number و mono size
+
+335
+00:27:57,540 --> 00:28:02,040
+وهي normal hyper or hypercellular bone marrow
+
+336
+00:28:02,040 --> 00:28:05,960
+وبيشكل 25% من الحالات
+
+337
+00:28:11,280 --> 00:28:16,020
+اللي هو بيكون فيه خمسة لعشرين فلمية blast في ال
+
+338
+00:28:16,020 --> 00:28:19,880
+bone marrow قل من خمسة فلمية في ال blood stream في
+
+339
+00:28:19,880 --> 00:28:24,960
+cytopenia في at least in at least two line وفي
+
+340
+00:28:24,960 --> 00:28:28,260
+normal or hypercellular bone marrow بشكل خمسة
+
+341
+00:28:28,260 --> 00:28:35,480
+وخمسة عشر لعشرين فلمية من حالات ال MDS IUCMML
+
+342
+00:28:35,480 --> 00:28:40,370
+splenomegalyمايكيلوب popular skin infiltration
+
+343
+00:28:40,370 --> 00:28:46,250
+بيكون في monocytic plural او pericardial effusion
+
+344
+00:28:46,250 --> 00:28:52,210
+وفي جوناع ال myelomonocytic leukemia مرات بيكون في
+
+345
+00:28:52,210 --> 00:28:57,990
+myeloproliferative dysplasia او myelodysplastic
+
+346
+00:28:57,990 --> 00:29:02,070
+syndrome pallor, bleeding, hepatosplenomegaly
+
+347
+00:29:02,070 --> 00:29:03,930
+وskin involvement
+
+348
+00:29:06,850 --> 00:29:13,910
+هذا ما يتعلق بالانواع اللى هو ال myelodysplasia
+
+349
+00:29:13,910 --> 00:29:19,070
+according to FAB classification لكن WHO إجت عملت
+
+350
+00:29:19,070 --> 00:29:24,070
+classification جديد للmyelodysplastic syndrome
+
+351
+00:29:24,070 --> 00:29:29,050
+وجالت لأ احنا الانواع بدنا نقسمها إلى تمان انواع
+
+352
+00:29:29,050 --> 00:29:34,090
+مش خمس انواع زى ما قسموها في الفابأيش الأنواع؟ هو
+
+353
+00:29:34,090 --> 00:29:37,470
+Refractory Anemia و Refractory Anemia with Ringed
+
+354
+00:29:37,470 --> 00:29:41,010
+Cedroblast ثم Refractory Cytopenia with
+
+355
+00:29:41,010 --> 00:29:45,530
+Multilineage Dysplasia و Refractory Cytopenia with
+
+356
+00:29:45,530 --> 00:29:49,770
+Multilineage Dysplasia and Ringed Cedroblast ثم
+
+357
+00:29:49,770 --> 00:29:53,930
+Refractory Anemia with Excessive Blast 1 و 2 ثم
+
+358
+00:29:53,930 --> 00:29:58,630
+Myelodysplastic Syndrome Unclassified مالوش ايه ثم
+
+359
+00:29:58,630 --> 00:30:09,430
+Associated withIsolated deletion of 5EQ.هو يجب أن
+
+360
+00:30:09,430 --> 00:30:12,110
+نقول إن الـ Refractory Anemia مصحوبة عادة
+
+361
+00:30:12,110 --> 00:30:15,730
+بالأنيميا وفي Erythroid dysplasia only، Ringed
+
+362
+00:30:15,730 --> 00:30:19,330
+Cedroblast في أنيميا وفي أكتر من 15% Ringed
+
+363
+00:30:19,330 --> 00:30:22,450
+Cedroblast، Refractory Cytopenia و Multilinear
+
+364
+00:30:22,450 --> 00:30:28,060
+Dysplasia في باي Bad Cytopenia، اتنين.والـ
+
+365
+00:30:28,060 --> 00:30:30,740
+Refractory Cytopenia with Multilinear Dysplasia
+
+366
+00:30:30,740 --> 00:30:34,060
+with Ringed Cedroblast بيكون فيه أكتر من 15%
+
+367
+00:30:34,060 --> 00:30:40,280
+Ringed Cedroblast وExcess Blast 1 بيكون لـ Blast
+
+368
+00:30:40,280 --> 00:30:44,260
+أقل من 5في ال blood واخر من خمسة لتسعة في ال bone
+
+369
+00:30:44,260 --> 00:30:48,500
+marrow وفي اتنين بيكون من خمسة لتسعة عشر في ال
+
+370
+00:30:48,500 --> 00:30:51,540
+peripheral blood ومن عشر لتسعة عشر في ال bone
+
+371
+00:30:51,540 --> 00:30:56,220
+marrow ال unclassified بيكون فيه cytopenia في ال
+
+372
+00:30:56,220 --> 00:31:01,320
+blood وفي myeloid or megakaryocyte dysplasia ال 5Q
+
+373
+00:31:01,320 --> 00:31:07,820
+type بيكون فيه أنميا و .. و بيكونش
+
+374
+00:31:10,480 --> 00:31:16,300
+انيميا ولا في زيادة في الـ Platelet لكن بيكون في
+
+375
+00:31:16,300 --> 00:31:21,720
+ميجا كاريوسيتك
+
+376
+00:31:21,720 --> 00:31:28,680
+Cell with high poly related nuclei أو أقل من 5%
+
+377
+00:31:28,680 --> 00:31:34,210
+بالحصة شو اللي بيقابل اشي في WHO مع الرفاق؟هو الـ
+
+378
+00:31:34,210 --> 00:31:36,790
+Refractory Anemia اللي بيقابلها في الـWHO
+
+379
+00:31:36,790 --> 00:31:39,690
+Refractory Anemia with Refractory Cytopenia with
+
+380
+00:31:39,690 --> 00:31:44,410
+Multilinear Dysplasia 5Q Syndrome Ring Syndrome
+
+381
+00:31:44,410 --> 00:31:53,650
+Blast برضه بيقابلها الرأس ورأس RCMDRS أو الرأس الـ
+
+382
+00:31:53,650 --> 00:31:56,910
+Excessive Blast 1 و2 Transformation with
+
+383
+00:31:56,910 --> 00:32:02,060
+Multilinear Dysplasiaوهي CML وهو myelodysplastic
+
+384
+00:32:02,060 --> 00:32:06,880
+myeloproliferative disease Prognostic group حتى
+
+385
+00:32:06,880 --> 00:32:11,700
+توجه لـ two prognostic group بناء على survival and
+
+386
+00:32:11,700 --> 00:32:17,160
+evolution to acute leukemia تجلب لـ acute leukemia
+
+387
+00:32:17,160 --> 00:32:21,660
+فجاله الجد group الناس اللي بيصير عندهم refractory
+
+388
+00:32:21,660 --> 00:32:25,040
+anemia او refractory anemia with ring cedroblast
+
+389
+00:32:25,040 --> 00:32:29,370
+او FAQ-بينما الـ Body Group هي الـ Refractory
+
+390
+00:32:29,370 --> 00:32:32,010
+Anemia وExcessive Blast وExcessive Blast in
+
+391
+00:32:32,010 --> 00:32:37,490
+Transformation وCMML وهي طبعا النوع التالت اللي هو
+
+392
+00:32:37,490 --> 00:32:43,070
+الـ Unclassified ممكن يكون في group one ولا group
+
+393
+00:32:43,070 --> 00:32:46,450
+two عنده
+
+394
+00:32:46,450 --> 00:32:51,750
+Prognostic Scoring System يعني قطوا Scores لكل
+
+395
+00:32:51,750 --> 00:32:56,750
+نقطة من المقات وبناء على عدد ال Scoresحددوا
+
+396
+00:32:56,750 --> 00:33:03,430
+البروجنوزيز فجأة ال IPSS بيعتمد على percentage of
+
+397
+00:33:03,430 --> 00:33:08,450
+blast على إذا في كرمزومة abnormality ولا لأ وقداش
+
+398
+00:33:08,450 --> 00:33:13,710
+المريض عنده blood count و هدولة بنحطوا score زي ما
+
+399
+00:33:13,710 --> 00:33:17,570
+قلتلكوا كل ما قل ال score كل ما كان جد البروجنوزيز
+
+400
+00:33:18,610 --> 00:33:23,590
+فايل بلاست يوم يكون أقل من خمسة بنعطى صفر لكن صار
+
+401
+00:33:23,590 --> 00:33:28,170
+خمسة لعشرة بسبب بياخد نص إذا كان أكتر من هيك بياخد
+
+402
+00:33:28,170 --> 00:33:32,570
+واحد من أحد عشر لعشرين واحد و نص و هكذا كاريو تايب
+
+403
+00:33:32,570 --> 00:33:37,490
+إذا positive ولا لأ the opinion ماشي إذا من صفر
+
+404
+00:33:37,490 --> 00:33:42,870
+لواحد صفر إذا من اتنين لتلاتة نص و هكذا تجمع هذه
+
+405
+00:33:42,870 --> 00:33:50,100
+الأرقام و كل ما قل الرقم كل ما كانprognosis got
+
+406
+00:33:50,100 --> 00:33:55,080
+differential diagnosis several common diagnostic
+
+407
+00:33:55,080 --> 00:34:02,320
+considerations given these findings طبعا بدك تعمل
+
+408
+00:34:02,320 --> 00:34:06,760
+تستثني عشان تشخص الmyelodysplasia تشخص تستثني
+
+409
+00:34:06,760 --> 00:34:10,920
+الحالات القاتيةنشوف أسباب الـ Bone Marrow Failure
+
+410
+00:34:10,920 --> 00:34:15,020
+الـ Diabetic أو الـ Drug Induced و نشيلها نشوف إذا
+
+411
+00:34:15,020 --> 00:34:20,260
+في Hypersplenism ولا لا ثم إذا في Vitamin B12 و
+
+412
+00:34:20,260 --> 00:34:25,500
+Orpholic Acid Deficiency و حالة الـ PNH ممكن يكون
+
+413
+00:34:25,500 --> 00:34:32,120
+عندها Similar Bone Marrow Finding مع الـ MDS طيب
+
+414
+00:34:32,120 --> 00:34:37,250
+كيف نعمل الـ Differentiation بين الـ Acute Nonالـ
+
+415
+00:34:37,250 --> 00:34:39,570
+Lymphoplastic Leukemia أو الـ Myelodysplasia
+
+416
+00:34:39,570 --> 00:34:50,050
+ببساطة نعمل القاتي من جهة نجيب نعمل
+
+417
+00:34:50,050 --> 00:34:58,310
+برفرة blood ونشوف
+
+418
+00:34:58,310 --> 00:35:06,150
+نسبة الـ Nucleated Cellنسبة الـ RBCs بالنسبة لـ
+
+419
+00:35:06,150 --> 00:35:11,870
+Nucleated Cell طبعا
+
+420
+00:35:11,870 --> 00:35:14,770
+ال .. عفوا احنا بنعمل .. ناخد bone marrow و في هذه
+
+421
+00:35:14,770 --> 00:35:17,690
+الـ bone marrow هي اللي بتحدد ناخد bone marrow و
+
+422
+00:35:17,690 --> 00:35:21,430
+بنتطلع عليه بنشوف نسبة ال RBCs بالنسبة لـ Total
+
+423
+00:35:21,430 --> 00:35:28,370
+Nucleated Cell فإذا كان ال RBCs .. Nucleated RBCs
+
+424
+00:35:28,370 --> 00:35:33,040
+أكتر من 50% بندور، بنشوف جدش فيها Blastولا إذا الـ
+
+425
+00:35:33,040 --> 00:35:38,400
+BLAST أكتر من 30% بيعنيته لوكيميا ومن نوع M6 وإذا
+
+426
+00:35:38,400 --> 00:35:43,120
+كان الـ BLAST أقل من 30% بيعنيته MDS للحالة
+
+427
+00:35:43,120 --> 00:35:49,840
+التانية، نشوف نسبة الـ Nucleated RBCs بالنسبة للـ
+
+428
+00:35:49,840 --> 00:35:53,340
+Nucleated Cell إذا أقل من 50%، ندور على جدّيش فيها
+
+429
+00:35:53,340 --> 00:35:57,960
+BLAST ولا إذا الـ BLAST أكتر من 30% بيعنيته
+
+430
+00:35:57,960 --> 00:36:03,950
+لوكيميا لنوع أخر من اللوكيميا غير M6وإذا كان الـ
+
+431
+00:36:03,950 --> 00:36:09,650
+Plasma أقل من 30% فهي MDS وبهيك بنفرق ما بين الـ
+
+432
+00:36:09,650 --> 00:36:12,790
+Acute Non-Lymphoblastic Leukemia و الـ MDS
+
+433
+00:36:12,790 --> 00:36:20,370
+Pathophysiology أهم حاجة أنه ندور على .. نعرف إيش
+
+434
+00:36:20,370 --> 00:36:23,330
+السبب فالـ Initial Hemopoietic Stem Cell Injury هو
+
+435
+00:36:23,330 --> 00:36:28,290
+السبب وطبعا هذه ممكن تكون due to cytotoxic
+
+436
+00:36:28,290 --> 00:36:33,740
+chemotherapy، radiation، viralو chemical exposure
+
+437
+00:36:33,740 --> 00:36:38,080
+or genetic predisposition الكرونية الميوتيشن اللي
+
+438
+00:36:38,080 --> 00:36:45,620
+بتكوّن over the bone marrow طبعا هو اللي بيشكل ال
+
+439
+00:36:45,620 --> 00:36:50,260
+substance ال healthy stem cell يعني هو اللي بيعيق
+
+440
+00:36:50,260 --> 00:36:56,810
+اللي هو نشاط ال stem cellبالنسبة للبرفيرال بلد
+
+441
+00:36:56,810 --> 00:37:05,070
+البرفيرال البرفيرال
+
+442
+00:37:05,070 --> 00:37:06,710
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+443
+00:37:06,710 --> 00:37:07,550
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+444
+00:37:07,550 --> 00:37:07,650
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+445
+00:37:07,650 --> 00:37:11,410
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+446
+00:37:11,410 --> 00:37:15,950
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+447
+00:37:15,950 --> 00:37:20,990
+الماشي برضه بنعمل cpc و blood film و بنشوف جداش
+
+448
+00:37:20,990 --> 00:37:24,370
+فيه premature RBC فيه عنينيا فيه macrovalocytosis
+
+449
+00:37:24,370 --> 00:37:27,750
+بيسبسه في الاستبلينج و هكذا كل ال abnormality
+
+450
+00:37:27,750 --> 00:37:31,470
+اليوكو ديسبليجيا تشوهت ال white braces برضه
+
+451
+00:37:31,470 --> 00:37:36,390
+بنشوفها و thrombodisplasia أيضا بتدور على
+
+452
+00:37:36,390 --> 00:37:39,530
+thrombocytopenia و اذا كان فيه large or tertiary
+
+453
+00:37:39,530 --> 00:37:43,340
+plateletهذا كلام كله في الـ peripheral blood في
+
+454
+00:37:43,340 --> 00:37:44,920
+الـ bone marrow نعمل نفس الاحكالة
+
+455
+00:37:44,920 --> 00:37:46,880
+erythrodysplasia, leukodysplasia, and
+
+456
+00:37:46,880 --> 00:37:51,640
+thrombodysplasia وهذا هو الجدول الذي يفرق ما بين
+
+457
+00:37:51,640 --> 00:37:56,700
+اللي هو ال peripheral blood و ال bone marrow في
+
+458
+00:37:56,700 --> 00:37:59,700
+الmyelodysplastic syndrome morphological
+
+459
+00:37:59,700 --> 00:38:08,080
+abnormality of اللي هو peripheral blood and bone
+
+460
+00:38:08,080 --> 00:38:12,130
+marrowفي ميليو ديس بلاستيك سندروم وطبعا بين انواع
+
+461
+00:38:12,130 --> 00:38:14,670
+مختلفة من الخلايا اللي هي الارثرويد وميليويد وميكا
+
+462
+00:38:14,670 --> 00:38:18,410
+كاريوسيت و هذا الجدول مش للحفظ لكن ضروري تعرفوا
+
+463
+00:38:18,410 --> 00:38:23,590
+انه فيه تشوهات وانواع هذه التشوهات survival time
+
+464
+00:38:23,590 --> 00:38:28,010
+جاله refractory انيميا بعيش من سنتين لخمس سنوات
+
+465
+00:38:28,010 --> 00:38:31,230
+with ring syndrome blast زي ال refractory انيميا
+
+466
+00:38:31,230 --> 00:38:36,080
+with excessive blastحوالي عشر شهود وهو نمره اتنين
+
+467
+00:38:36,080 --> 00:38:41,580
+و with excess blast in transformation ال survival
+
+468
+00:38:41,580 --> 00:38:48,760
+time is six month or less و طبعا هذه ال median
+
+469
+00:38:48,760 --> 00:38:51,520
+survival time للميلودسبلاستيكس سندرما زي ما انتوا
+
+470
+00:38:51,520 --> 00:38:52,500
+شايفين ده هي
+
+471
+00:38:56,110 --> 00:39:00,750
+النسبة لعدد الأشهر Treatment بيعطوه كيبو ثيرابي و
+
+472
+00:39:00,750 --> 00:39:04,630
+بيعطوه supportive therapy زي ال white PCR بيشيلوا
+
+473
+00:39:04,630 --> 00:39:11,350
+platelet transfusion و في الحالات الصغيرة الشباب
+
+474
+00:39:11,350 --> 00:39:16,590
+يعني بيعملوا bone monotransplantationو يا بيك
+
+475
+00:39:16,590 --> 00:39:21,530
+بنكون أنهينا المحاضرة ال Milo dysplasia ترجوا أن
+
+476
+00:39:21,530 --> 00:39:25,550
+تكونوا قد استفدتم و فهمتم و شكرا
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..36402dab18cb1fb456332604362e249f6012075d
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 1723, "start": 1.57, "end": 17.23, "text": "بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة بعنوان myelodysplastic syndrome وmyelodysplastic syndrome هي عبارة عن مجموعة من", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8717, 1211, 2655, 38436, 45595, 20498, 8978, 3714, 5016, 46958, 25720, 10874, 16254, 41891, 45030, 1863, 2407, 7649, 452, 338, 378, 749, 564, 2750, 19371, 4032, 2226, 338, 378, 749, 564, 2750, 19371, 39896, 6225, 3555, 9640, 3660, 18871, 3714, 7435, 2304, 2407, 27884, 9154], "avg_logprob": -0.12578124566511675, "compression_ratio": 1.4306569343065694, "no_speech_prob": 0.0002390146255493164, "words": [{"start": 1.57, "end": 1.85, "word": "بسم", "probability": 0.835693359375}, {"start": 1.85, "end": 2.09, "word": " الله", "probability": 0.94287109375}, {"start": 2.09, "end": 2.43, "word": " الرحمن", "probability": 0.9580078125}, {"start": 2.43, "end": 2.91, "word": " الرحيم", "probability": 0.9913736979166666}, {"start": 2.91, "end": 5.79, "word": " نلتقي", "probability": 0.8682861328125}, {"start": 5.79, "end": 6.05, "word": " اليوم", "probability": 0.963623046875}, {"start": 6.05, "end": 6.17, "word": " في", "probability": 0.91357421875}, {"start": 6.17, "end": 6.61, "word": " محاضرة", "probability": 0.970947265625}, {"start": 6.61, "end": 7.11, "word": " جديدة", "probability": 0.986328125}, {"start": 7.11, "end": 7.61, "word": " بعنوان", "probability": 0.916259765625}, {"start": 7.61, "end": 8.63, "word": " myelodysplastic", "probability": 0.8251139322916666}, {"start": 8.63, "end": 9.87, "word": " syndrome", "probability": 0.9169921875}, {"start": 9.87, "end": 15.19, "word": " وmyelodysplastic", "probability": 0.7825404575892857}, {"start": 15.19, "end": 15.67, "word": " syndrome", "probability": 0.921875}, {"start": 15.67, "end": 15.93, "word": " هي", "probability": 0.81884765625}, {"start": 15.93, "end": 16.19, "word": " عبارة", "probability": 0.929443359375}, {"start": 16.19, "end": 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52.59, "word": " dysfunction", "probability": 0.92822265625}, {"start": 52.59, "end": 53.11, "word": " لأن", "probability": 0.607421875}, {"start": 53.11, "end": 53.17, "word": " ال", "probability": 0.80078125}, {"start": 53.17, "end": 53.27, "word": " bone", "probability": 0.49560546875}, {"start": 53.27, "end": 53.45, "word": " marrow", "probability": 0.9560546875}, {"start": 53.45, "end": 53.81, "word": " مشتغل", "probability": 0.8607177734375}, {"start": 53.81, "end": 54.19, "word": " صح", "probability": 0.861083984375}, {"start": 54.19, "end": 55.83, "word": " ببساطة", "probability": 0.9498046875}, {"start": 55.83, "end": 56.05, "word": " ال", "probability": 0.9267578125}, {"start": 56.05, "end": 56.21, "word": " bone", "probability": 0.96240234375}, {"start": 56.21, "end": 56.51, "word": " marrow", "probability": 0.96923828125}, {"start": 56.51, "end": 57.43, "word": " مابشتغل", "probability": 0.8606770833333334}, {"start": 57.43, "end": 58.73, "word": " صح", "probability": 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"end": 91.15, "word": " الخلايا", "probability": 0.95458984375}, {"start": 91.15, "end": 91.99, "word": " تتكسر", "probability": 0.9599609375}, {"start": 91.99, "end": 93.01, "word": " محصلة", "probability": 0.956298828125}, {"start": 93.01, "end": 93.21, "word": " هذا", "probability": 0.9404296875}, {"start": 93.21, "end": 93.85, "word": " الكلام", "probability": 0.9620768229166666}, {"start": 93.85, "end": 94.59, "word": " أنه", "probability": 0.6431884765625}, {"start": 94.59, "end": 94.91, "word": " بيصير", "probability": 0.818359375}, {"start": 94.91, "end": 95.21, "word": " في", "probability": 0.77197265625}, {"start": 95.21, "end": 96.09, "word": " shortage", "probability": 0.440673828125}, {"start": 96.09, "end": 96.41, "word": " في", "probability": 0.96484375}, {"start": 96.41, "end": 96.67, "word": " blood", "probability": 0.52783203125}, {"start": 96.67, "end": 97.09, "word": " cell", "probability": 0.7138671875}], "temperature": 1.0}, {"id": 5, "seek": 12232, "start": 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"end": 697.89, "text": "أب نورمالتي في كرمزوم تلاتة بعمل ميجا كاريوبيسيس وthrombocytosis وهذا غالبا مصحوب بهذا الاب نورمالتي طيب شوف ايديت importance of indication of كرمزوم الاب نورمالتي يقول نمرة واحد to confirm diagnosis نمرة اتنين to know the stage of disease نمرة تلاتة to know the direction of progression of disease", "tokens": [10721, 3555, 8717, 13063, 2304, 6027, 31371, 8978, 9122, 2288, 2304, 11622, 20498, 6055, 1211, 9307, 3660, 4724, 25957, 1211, 3714, 1829, 7435, 995, 9122, 9640, 1829, 2407, 21292, 3794, 1829, 3794, 4032, 392, 81, 3548, 905, 4328, 8211, 37037, 15730, 32771, 6027, 3555, 995, 3714, 9381, 5016, 37746, 39627, 15730, 2423, 16758, 8717, 13063, 2304, 6027, 31371, 23032, 1829, 3555, 13412, 38688, 1975, 1829, 16254, 2655, 7379, 295, 18877, 295, 9122, 2288, 2304, 11622, 20498, 2423, 16758, 8717, 13063, 2304, 6027, 31371, 7251, 39648, 8717, 2304, 25720, 36764, 24401, 281, 9064, 15217, 8717, 2304, 25720, 1975, 2655, 1863, 9957, 281, 458, 264, 3233, 295, 4752, 8717, 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جاله", "probability": 0.6544596354166666}, {"start": 2303.87, "end": 2304.31, "word": " refractory", "probability": 0.5611572265625}, {"start": 2304.31, "end": 2304.61, "word": " انيميا", "probability": 0.635986328125}, {"start": 2304.61, "end": 2304.97, "word": " بعيش", "probability": 0.8556315104166666}, {"start": 2304.97, "end": 2305.17, "word": " من", "probability": 0.98046875}, {"start": 2305.17, "end": 2306.55, "word": " سنتين", "probability": 0.9650065104166666}, {"start": 2306.55, "end": 2306.91, "word": " لخمس", "probability": 0.97314453125}, {"start": 2306.91, "end": 2308.01, "word": " سنوات", "probability": 0.9156494140625}, {"start": 2308.01, "end": 2308.31, "word": " with", "probability": 0.38818359375}, {"start": 2308.31, "end": 2308.53, "word": " ring", "probability": 0.490966796875}, {"start": 2308.53, "end": 2308.83, "word": " syndrome", "probability": 0.287353515625}, {"start": 2308.83, "end": 2309.25, "word": " blast", "probability": 0.7109375}, {"start": 2309.25, "end": 2310.07, "word": " زي", "probability": 0.896240234375}, {"start": 2310.07, "end": 2310.19, "word": " ال", "probability": 0.91796875}, {"start": 2310.19, "end": 2310.69, "word": " refractory", "probability": 0.818359375}, {"start": 2310.69, "end": 2311.23, "word": " انيميا", "probability": 0.9314778645833334}, {"start": 2311.23, "end": 2311.75, "word": " with", "probability": 0.359619140625}, {"start": 2311.75, "end": 2312.15, "word": " excessive", "probability": 0.84619140625}, {"start": 2312.15, "end": 2312.71, "word": " blast", "probability": 0.67138671875}], "temperature": 1.0}, {"id": 89, "seek": 233250, "start": 2313.68, "end": 2332.5, "text": "حوالي عشر شهود وهو نمره اتنين و with excess blast in transformation ال survival time is six month or less و طبعا هذه ال median survival time للميلودسبلاستيكس سندرما زي ما انتوا شايفين ده هي", "tokens": [5016, 2407, 6027, 1829, 6225, 46309, 13412, 3224, 23328, 37037, 2407, 8717, 29973, 3224, 1975, 2655, 1863, 9957, 4032, 365, 9310, 12035, 294, 9887, 2423, 12559, 565, 307, 2309, 1618, 420, 1570, 4032, 23032, 3555, 3615, 995, 29538, 2423, 26779, 12559, 565, 5296, 19528, 26895, 23328, 3794, 3555, 15040, 14851, 1829, 4117, 3794, 8608, 41260, 2288, 15042, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 11778, 3224, 39896], "avg_logprob": -0.36971830985915494, "compression_ratio": 1.3762886597938144, "no_speech_prob": 5.066394805908203e-06, "words": [{"start": 2313.68, "end": 2314.04, "word": "حوالي", "probability": 0.7093505859375}, {"start": 2314.04, "end": 2314.28, "word": " عشر", "probability": 0.882080078125}, {"start": 2314.28, "end": 2314.9, "word": " شهود", "probability": 0.984375}, {"start": 2314.9, "end": 2315.36, "word": " وهو", "probability": 0.65478515625}, {"start": 2315.36, "end": 2315.7, "word": " نمره", "probability": 0.5939127604166666}, {"start": 2315.7, "end": 2316.08, "word": " اتنين", "probability": 0.91650390625}, {"start": 2316.08, "end": 2316.82, "word": " و", "probability": 0.6826171875}, {"start": 2316.82, "end": 2317.94, "word": " with", "probability": 0.405517578125}, {"start": 2317.94, "end": 2318.32, "word": " excess", "probability": 0.5556640625}, {"start": 2318.32, "end": 2318.68, "word": " blast", "probability": 0.370361328125}, {"start": 2318.68, "end": 2318.9, "word": " in", "probability": 0.5771484375}, {"start": 2318.9, "end": 2319.66, "word": " transformation", "probability": 0.7763671875}, {"start": 2319.66, "end": 2320.88, "word": " ال", "probability": 0.81787109375}, {"start": 2320.88, "end": 2321.58, "word": " survival", "probability": 0.92578125}, {"start": 2321.58, "end": 2322.06, "word": " time", "probability": 0.8955078125}, {"start": 2322.06, "end": 2322.46, "word": " is", "probability": 0.9326171875}, {"start": 2322.46, "end": 2322.84, "word": " six", "probability": 0.80224609375}, {"start": 2322.84, "end": 2323.52, "word": " month", "probability": 0.4912109375}, {"start": 2323.52, "end": 2324.08, "word": " or", "probability": 0.95654296875}, {"start": 2324.08, "end": 2325.14, "word": " less", "probability": 0.94873046875}, {"start": 2325.14, "end": 2328.0, "word": " و", "probability": 0.5537109375}, {"start": 2328.0, "end": 2328.26, "word": " طبعا", "probability": 0.917236328125}, {"start": 2328.26, "end": 2328.4, "word": " هذه", "probability": 0.341552734375}, {"start": 2328.4, "end": 2328.52, "word": " ال", "probability": 0.60986328125}, {"start": 2328.52, "end": 2328.76, "word": " median", "probability": 0.56201171875}, {"start": 2328.76, "end": 2329.18, "word": " survival", "probability": 0.97998046875}, {"start": 2329.18, "end": 2329.64, "word": " time", "probability": 0.91650390625}, {"start": 2329.64, "end": 2330.72, "word": " للميلودسبلاستيكس", "probability": 0.6715642755681818}, {"start": 2330.72, "end": 2331.06, "word": " سندرما", "probability": 0.59222412109375}, {"start": 2331.06, "end": 2331.28, "word": " زي", "probability": 0.68994140625}, {"start": 2331.28, "end": 2331.34, "word": " ما", "probability": 0.53125}, {"start": 2331.34, "end": 2331.52, "word": " انتوا", "probability": 0.8308919270833334}, {"start": 2331.52, "end": 2331.94, "word": " شايفين", "probability": 0.96923828125}, {"start": 2331.94, "end": 2332.22, "word": " ده", "probability": 0.71875}, {"start": 2332.22, "end": 2332.5, "word": " هي", "probability": 0.876953125}], "temperature": 1.0}, {"id": 90, "seek": 235431, "start": 2336.11, "end": 2354.31, "text": "النسبة لعدد الأشهر Treatment بيعطوه كيبو ثيرابي و بيعطوه supportive therapy زي ال white PCR بيشيلوا platelet transfusion و في الحالات الصغيرة الشباب يعني بيعملوا bone monotransplantation", "tokens": [6027, 1863, 35457, 3660, 5296, 22488, 3215, 16247, 8592, 3224, 2288, 20298, 518, 4724, 40228, 9566, 2407, 3224, 9122, 1829, 3555, 2407, 38637, 13546, 16758, 1829, 4032, 4724, 40228, 9566, 2407, 3224, 14435, 9492, 30767, 1829, 2423, 2418, 44022, 4724, 1829, 8592, 26895, 14407, 5924, 2631, 22666, 5704, 4032, 8978, 21542, 6027, 9307, 31767, 17082, 48923, 25124, 3555, 16758, 37495, 22653, 4724, 1829, 25957, 1211, 14407, 9026, 1108, 310, 25392, 13067, 399], "avg_logprob": -0.31549656227843403, "compression_ratio": 1.3917525773195876, "no_speech_prob": 7.152557373046875e-07, "words": [{"start": 2336.11, "end": 2336.75, "word": "النسبة", "probability": 0.72381591796875}, {"start": 2336.75, "end": 2337.19, "word": " لعدد", "probability": 0.91259765625}, {"start": 2337.19, "end": 2337.77, "word": " الأشهر", "probability": 0.962158203125}, {"start": 2337.77, "end": 2338.95, "word": " Treatment", "probability": 0.54302978515625}, {"start": 2338.95, "end": 2339.35, "word": " بيعطوه", "probability": 0.627392578125}, {"start": 2339.35, "end": 2339.63, "word": " كيبو", "probability": 0.7435302734375}, {"start": 2339.63, "end": 2340.17, "word": " ثيرابي", "probability": 0.798583984375}, {"start": 2340.17, "end": 2340.75, "word": " و", "probability": 0.75732421875}, {"start": 2340.75, "end": 2341.17, "word": " بيعطوه", "probability": 0.863330078125}, {"start": 2341.17, "end": 2341.77, "word": " supportive", "probability": 0.9443359375}, {"start": 2341.77, "end": 2342.45, "word": " therapy", "probability": 0.93408203125}, {"start": 2342.45, "end": 2343.39, "word": " زي", "probability": 0.861328125}, {"start": 2343.39, "end": 2343.49, "word": " ال", "probability": 0.90869140625}, {"start": 2343.49, "end": 2343.63, "word": " white", "probability": 0.444091796875}, {"start": 2343.63, "end": 2343.95, "word": " PCR", "probability": 0.0894775390625}, {"start": 2343.95, "end": 2344.63, "word": " بيشيلوا", "probability": 0.625927734375}, {"start": 2344.63, "end": 2344.97, "word": " platelet", "probability": 0.54888916015625}, {"start": 2344.97, "end": 2345.69, "word": " transfusion", "probability": 0.638671875}, {"start": 2345.69, "end": 2346.55, "word": " و", "probability": 0.8408203125}, {"start": 2346.55, "end": 2347.81, "word": " في", "probability": 0.51025390625}, {"start": 2347.81, "end": 2348.65, "word": " الحالات", "probability": 0.9894205729166666}, {"start": 2348.65, "end": 2350.29, "word": " الصغيرة", "probability": 0.9728190104166666}, {"start": 2350.29, "end": 2351.35, "word": " الشباب", "probability": 0.9734700520833334}, {"start": 2351.35, "end": 2351.73, "word": " يعني", "probability": 0.85986328125}, {"start": 2351.73, "end": 2352.83, "word": " بيعملوا", "probability": 0.934765625}, {"start": 2352.83, "end": 2353.15, "word": " bone", "probability": 0.8369140625}, {"start": 2353.15, "end": 2354.31, "word": " monotransplantation", "probability": 0.839990234375}], "temperature": 1.0}, {"id": 91, "seek": 236555, "start": 2355.43, "end": 2365.55, "text": "و يا بيك بنكون أنهينا المحاضرة ال Milo dysplasia ترجوا أن تكونوا قد استفدتم و فهمتم و شكرا", "tokens": [2407, 35186, 4724, 1829, 4117, 4724, 1863, 30544, 14739, 3224, 1829, 8315, 9673, 5016, 46958, 25720, 2423, 7036, 78, 15243, 564, 25251, 6055, 47341, 14407, 14739, 6055, 30544, 14407, 12174, 3215, 44713, 5172, 3215, 39237, 4032, 6156, 16095, 39237, 4032, 13412, 4117, 23557], "avg_logprob": -0.36470169641754846, "compression_ratio": 1.2195121951219512, "no_speech_prob": 4.76837158203125e-07, "words": [{"start": 2355.43, "end": 2355.79, "word": "و", "probability": 0.58447265625}, {"start": 2355.79, "end": 2356.05, "word": " يا", "probability": 0.08258056640625}, {"start": 2356.05, "end": 2356.59, "word": " بيك", "probability": 0.8649088541666666}, {"start": 2356.59, "end": 2357.69, "word": " بنكون", "probability": 0.6496175130208334}, {"start": 2357.69, "end": 2358.23, "word": " أنهينا", "probability": 0.7930908203125}, {"start": 2358.23, "end": 2358.99, "word": " المحاضرة", "probability": 0.907470703125}, {"start": 2358.99, "end": 2359.17, "word": " ال", "probability": 0.35400390625}, {"start": 2359.17, "end": 2359.49, "word": " Milo", "probability": 0.29827880859375}, {"start": 2359.49, "end": 2360.17, "word": " dysplasia", "probability": 0.880859375}, {"start": 2360.17, "end": 2361.37, "word": " ترجوا", "probability": 0.752197265625}, {"start": 2361.37, "end": 2361.53, "word": " أن", "probability": 0.61376953125}, {"start": 2361.53, "end": 2361.97, "word": " تكونوا", "probability": 0.8356119791666666}, {"start": 2361.97, "end": 2362.19, "word": " قد", "probability": 0.777587890625}, {"start": 2362.19, "end": 2362.87, "word": " استفدتم", "probability": 0.950439453125}, {"start": 2362.87, "end": 2363.25, "word": " و", "probability": 0.93994140625}, {"start": 2363.25, "end": 2364.99, "word": " فهمتم", "probability": 0.8880208333333334}, {"start": 2364.99, "end": 2365.15, "word": " و", "probability": 0.904296875}, {"start": 2365.15, "end": 2365.55, "word": " شكرا", "probability": 0.9482421875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2366.3688125, "duration_after_vad": 2300.6343749999946}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..228dfaf2b8cd1e01281fe5d9aa1d0c98d30e2567
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/7Ndy6AD1A7M_raw.srt
@@ -0,0 +1,1924 @@
+1
+00:00:01,570 --> 00:00:07,110
+بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة
+
+2
+00:00:07,110 --> 00:00:15,190
+بعنوان myelodysplastic syndrome وmyelodysplastic
+
+3
+00:00:15,190 --> 00:00:22,060
+syndrome هي عبارة عن مجموعة منالـ Disorders التي
+
+4
+00:00:22,060 --> 00:00:27,640
+تتميز بواحد او اكتر من واحد من ال peripheral blood
+
+5
+00:00:27,640 --> 00:00:30,960
+cytopenia شو يعني peripheral blood cytopenia يعني
+
+6
+00:00:30,960 --> 00:00:37,060
+قلة في one cellular element or more cellular
+
+7
+00:00:37,060 --> 00:00:42,330
+elementand this is reflected in peripheral blood
+
+8
+00:00:42,330 --> 00:00:50,930
+as قلة less in count طبعا هذا الكلام ليه جاله
+
+9
+00:00:50,930 --> 00:00:53,270
+secondary to bone marrow dysfunction لأن ال bone
+
+10
+00:00:53,270 --> 00:00:58,730
+marrow مشتغل صح ببساطة ال bone marrow مابشتغل صح
+
+11
+00:00:58,730 --> 00:01:04,610
+في ال MDS ال bone marrow لا يستطيع ان ينتج خلايا
+
+12
+00:01:04,610 --> 00:01:10,250
+effectively يعني بشكل سليموبالتالي الخلايا التي
+
+13
+00:01:10,250 --> 00:01:13,990
+تتكون هي عبارة عن defective cell بينجوسين هي عبارة
+
+14
+00:01:13,990 --> 00:01:19,610
+عن خلايا مشوهة للخلايا الغير طبيعية الجسم أول بول
+
+15
+00:01:19,610 --> 00:01:24,630
+بقتلها وتقتل من التخلص منها في البومارو أو بعد
+
+16
+00:01:24,630 --> 00:01:28,330
+خروجها في ال peripheral blood سمير بفترة قصيرة
+
+17
+00:01:28,330 --> 00:01:33,210
+محصلة هذا الكلام مدام الخلايا تتكسر محصلة هذا
+
+18
+00:01:33,210 --> 00:01:39,120
+الكلام أنه بيصير في shortage في blood cellوهذا
+
+19
+00:01:39,120 --> 00:01:42,940
+يمكن أن يتم تفكيره بـ No blood count
+
+20
+00:01:42,940 --> 00:01:46,240
+Characteristics
+
+21
+00:01:46,240 --> 00:01:49,560
+كانوا يتميز بالقادة هذا المرض varying degree of
+
+22
+00:01:49,560 --> 00:01:54,940
+trilineal cytopenia تلت أنواع من الخلايا RBCs
+
+23
+00:01:54,940 --> 00:02:01,040
+وHPCs وPlatelets dysplasia تشوهات normocellular or
+
+24
+00:02:01,040 --> 00:02:06,460
+hypercellular pulmonaryوهذه المرضية قد تتطور إلى
+
+25
+00:02:06,460 --> 00:02:11,020
+اكيدلوكيميا ممكن يقلب ببساطة لأكيدلوكيميا
+
+26
+00:02:11,020 --> 00:02:14,860
+Symptoms, Sign and Symptoms طبيعي جدا في بولمارو
+
+27
+00:02:14,860 --> 00:02:20,480
+فاليار فبالتالي في انيميا ونيوتروبينيا وانفكشن
+
+28
+00:02:20,480 --> 00:02:25,760
+فالانيميا is manifested by excessive tiredness
+
+29
+00:02:25,760 --> 00:02:31,040
+shortness of breath pale skin that is correlated
+
+30
+00:02:31,040 --> 00:02:35,790
+with anemiaوهي عبارة عن shortage of RBCs و ال
+
+31
+00:02:35,790 --> 00:02:39,510
+neutropenia او ال infection serious infection مع
+
+32
+00:02:39,510 --> 00:02:44,330
+high fever that also can be caused by leukopenia
+
+33
+00:02:44,330 --> 00:02:50,150
+بمعنى ان مافيش white blood cell كفاية وبالذات ال
+
+34
+00:02:50,150 --> 00:02:58,650
+neutrophil وبالتالي في few mature granulocytes و
+
+35
+00:02:58,650 --> 00:03:03,470
+ال excessive bruising اللي هو ماشية معطبعا بيصير
+
+36
+00:03:03,470 --> 00:03:06,270
+فيه severe nause bleeding او bleeding from the
+
+37
+00:03:06,270 --> 00:03:10,930
+gums that can be due to thrombocytopenia بمعنى انه
+
+38
+00:03:10,930 --> 00:03:16,290
+مافيش بليدلت كفاية في الجسم عشان to plug the holes
+
+39
+00:03:16,290 --> 00:03:21,530
+in damaged blood vessels incidence هذا عبارة عن
+
+40
+00:03:21,530 --> 00:03:24,790
+disease of elderly people median age خمسة وستين
+
+41
+00:03:24,790 --> 00:03:30,850
+سنة اذا كان كان
+
+42
+00:03:30,850 --> 00:03:36,380
+طبعا فيأقل من 10% من الحالات بيكونوا في أقل من 50
+
+43
+00:03:36,380 --> 00:03:42,520
+سنة وبالتالي ال incidence rate بتكون واحد لكل 100
+
+44
+00:03:42,520 --> 00:03:49,820
+ألف في ال population لكنها تزيد إلى واحد لكل ألف
+
+45
+00:03:49,820 --> 00:03:53,900
+من ال population في الأعمار الكبيرة اللي هي أكبر
+
+46
+00:03:53,900 --> 00:03:58,360
+من 60 سنة وال male is slightly higher than female
+
+47
+00:03:59,910 --> 00:04:04,490
+أسباب حطوا سببين لهذا الموضوع كانوا فيه نوعين من
+
+48
+00:04:04,490 --> 00:04:09,330
+ال MDS نوع بيسموه de novo اللي هو الأصلي الأساسي
+
+49
+00:04:09,330 --> 00:04:11,930
+واللي غالبا associated with benzene exposure
+
+50
+00:04:11,930 --> 00:04:16,410
+cigarette smoker and viruses وفي نوع منه
+
+51
+00:04:16,410 --> 00:04:20,830
+congenital بيسموه Fanconi's anemia نوع من ال
+
+52
+00:04:20,830 --> 00:04:25,010
+congenital disease بيسموها Fanconi's anemia sorry
+
+53
+00:04:25,010 --> 00:04:29,810
+هذا plastic anemiaالنوع التاني هو therapy related
+
+54
+00:04:29,810 --> 00:04:32,970
+و therapy induced and usually associated with
+
+55
+00:04:32,970 --> 00:04:37,270
+alkalizing agent chemotherapy or radiation بيحصل
+
+56
+00:04:37,270 --> 00:04:42,970
+نتيجة أخذ المريض هذه الكمياء دي لحالات هذه المواد
+
+57
+00:04:42,970 --> 00:04:49,030
+الكيموية و هذه العلاجات بيصير في عنده MDS هذه صورة
+
+58
+00:04:49,030 --> 00:04:55,170
+جيدة جدا بتودحنا أو بتفهمنا بالظبط أنواع اللي هو
+
+59
+00:04:55,850 --> 00:04:59,790
+الـ hematological ماليجنازي إذا فهمناها بنفهم
+
+60
+00:04:59,790 --> 00:05:06,750
+بنقدر نعرف تقسمتها فلأنه بيوضح اللي هو أضرع أو
+
+61
+00:05:06,750 --> 00:05:13,350
+ذراعي ال hemapoiesis كنا بنعرف أن ال stem cell ب
+
+62
+00:05:13,350 --> 00:05:18,750
+.. كان proliferate يعني الذراعين المطلوبين
+
+63
+00:05:18,750 --> 00:05:22,610
+proliferation و differentiation ماشي
+
+64
+00:05:25,890 --> 00:05:32,110
+ففي الـ MDS الخلل يكون في الـ differentiation
+
+65
+00:05:32,110 --> 00:05:37,590
+فبالتالي المحص لإيش؟ هي this plastic form of cell
+
+66
+00:05:37,590 --> 00:05:43,710
+وبما أن الخلل في كل أنواع الخلايا يبقى بيصير فيه
+
+67
+00:05:43,710 --> 00:05:49,650
+tri lineage cytopenia بينما لو كان الخلل في ذراع
+
+68
+00:05:49,650 --> 00:05:53,550
+ال proliferationبتعمل مرض بيسموه اللي هو Non
+
+69
+00:05:53,550 --> 00:05:58,790
+Leukemic Proliferative Disease و لو كان الخلل في
+
+70
+00:05:58,790 --> 00:06:05,650
+الذراعين إضافة إلى dominant of mutant type يعني في
+
+71
+00:06:05,650 --> 00:06:11,230
+prominent cell type which
+
+72
+00:06:11,230 --> 00:06:15,050
+is dominant بيتكون
+
+73
+00:06:15,050 --> 00:06:18,970
+الحالة Leukemia يمكن في ال Leukemia الذراعين
+
+74
+00:06:18,970 --> 00:06:31,500
+مضربينوهي فيه mutant agents في ال MDS الذراع ال
+
+75
+00:06:31,500 --> 00:06:34,880
+differentiation بيكون مضروب في ال non-logistic
+
+76
+00:06:34,880 --> 00:06:38,440
+proliferative disorders ال proliferation بيكون
+
+77
+00:06:38,440 --> 00:06:39,420
+مضروب
+
+78
+00:06:41,880 --> 00:06:45,460
+طبعا الـ Ethological agents عنده قائمة طويلة عريضة
+
+79
+00:06:45,460 --> 00:06:49,480
+جدا ممكن تكون سبب لهذه الأمراض على هذا المرض زي ال
+
+80
+00:06:49,480 --> 00:06:52,000
+tobacco, ionizing radiation, organic chemical
+
+81
+00:06:52,000 --> 00:06:57,180
+بأنواعها heavy metal, herbicides و pesticides و
+
+82
+00:06:57,180 --> 00:07:00,980
+fertilizers بجموعة كثيرة من ال calculating agent و
+
+83
+00:07:00,980 --> 00:07:07,340
+petroleum و هكذا طبعا هذا محصلته كرمزوم ال
+
+84
+00:07:07,340 --> 00:07:11,060
+abnormality وسجلت حالات كرمزوم ال abnormalityفي
+
+85
+00:07:11,060 --> 00:07:15,380
+أكتر من خمسين فمية من الدنوبة وفي حوالي كل حالات
+
+86
+00:07:15,380 --> 00:07:21,580
+ال secondary أو ال therapy related MDS طبعا هذه
+
+87
+00:07:21,580 --> 00:07:26,700
+عبارة عن أمثلة فقط لحالات ال chromosome ال
+
+88
+00:07:26,700 --> 00:07:30,660
+abnormality اللي بتتصاحب أو بتكون موجودة في ال MDS
+
+89
+00:07:30,660 --> 00:07:37,120
+فهي زي ما انتوا شايفين five U minus ماشي seven
+
+90
+00:07:37,120 --> 00:07:45,490
+elevenمنظومي سمن وكذا عدد كثيرة من كرومزومة ال
+
+91
+00:07:45,490 --> 00:07:48,550
+abnormality طبعا من أشهرها deletion of the long
+
+92
+00:07:48,550 --> 00:07:57,010
+arm of chromosome 5 5Q minus syndrome and حتى
+
+93
+00:07:57,010 --> 00:08:06,490
+اليوم في يعني نوع اسمه 5Q minus syndrome or 5Q
+
+94
+00:08:06,490 --> 00:08:12,800
+minus MDSهو مرتبط بشكل كبير بـRheumatoid with
+
+95
+00:08:12,800 --> 00:08:14,580
+refractory anemia
+
+96
+00:08:18,460 --> 00:08:22,520
+وبيشكل حوالي 70% هذا الـ Cytogenetic abnormality
+
+97
+00:08:22,520 --> 00:08:27,520
+of this type طبعا في منطقة الـ Q arm of chromosome
+
+98
+00:08:27,520 --> 00:08:32,220
+number 7 وجدوا انه في معظم الجينات اللي مسؤول عنهم
+
+99
+00:08:32,220 --> 00:08:35,980
+weight and growth factor وبالتالي غيابها معناته
+
+100
+00:08:35,980 --> 00:08:40,440
+مافيش growth factor زي IL 3 أو 4 أو 5 أو GM CSF و
+
+101
+00:08:40,440 --> 00:08:46,190
+MCSF وبالتالي ال receptorأيضًا كمان غايب لأن هو
+
+102
+00:08:46,190 --> 00:08:50,090
+gene and receptor growth factor and their receptor
+
+103
+00:08:50,090 --> 00:08:55,910
+وبالتالي طبعًا فقدر هذه المواد هيأدى الى
+
+104
+00:08:55,910 --> 00:09:01,810
+disruption or overdraft of overdraft hemopoiesis
+
+105
+00:09:01,810 --> 00:09:09,190
+monosomy 7 and 7q- أيضًا associated with secondary
+
+106
+00:09:09,190 --> 00:09:16,490
+MDS ويجروا في هذه المنطقةفي الـ major surface
+
+107
+00:09:16,490 --> 00:09:23,750
+glycoprotein 130 وبالتالي غيابه معناته في غياب لـ
+
+108
+00:09:23,750 --> 00:09:26,710
+neutrophil function and susceptibility to
+
+109
+00:09:26,710 --> 00:09:29,930
+bacterial infection غالبا لإن
+
+110
+00:09:29,930 --> 00:09:34,870
+الجرانيلوسيتمولوسيتكموتاكتك activity is defected
+
+111
+00:09:34,870 --> 00:09:39,310
+11Q- deletion of 11Q
+
+112
+00:09:41,750 --> 00:09:46,730
+شكل هذا حوالي عشرين فمية من حالات الراس Refractory
+
+113
+00:09:46,730 --> 00:09:50,630
+أنيمة with ringed cedroblast و لسه abnormality
+
+114
+00:09:50,630 --> 00:09:55,030
+غالبا associated with raised iron stores تلاقي ال
+
+115
+00:09:55,030 --> 00:09:58,250
+iron stores عالية و يصير فيها ringed cedroblast
+
+116
+00:09:58,250 --> 00:10:06,030
+السبب في ذلك وجود الجين المسؤول عن ال H subunit of
+
+117
+00:10:06,030 --> 00:10:12,510
+ferritinفي هذه المنطقة وعلى كرمزوم رقم 11 وذلك
+
+118
+00:10:12,510 --> 00:10:21,150
+ايضا ما يفسر زيادة iron store abnormality في
+
+119
+00:10:21,150 --> 00:10:28,830
+كرمزوم 17 طبعا a inversion of 17Q قالوا في هذه
+
+120
+00:10:28,830 --> 00:10:35,310
+المنطقة يوجد ال B53 او tumor saprosargen اللى
+
+121
+00:10:35,310 --> 00:10:42,420
+موجود في كثير من الحلات من الو بالذات
+
+122
+00:10:42,420 --> 00:10:46,520
+لما تجلب ل البلاستيك من ال plastic phase من ال
+
+123
+00:10:46,520 --> 00:10:53,480
+chronic phase ل البلاستيك phase و تقريبا حوالي 5%
+
+124
+00:10:53,480 --> 00:11:03,680
+من الحالات of primary MDS طبعا هذا بيدي الى this
+
+125
+00:11:03,680 --> 00:11:06,660
+plastic feature of cells and neutrophil
+
+126
+00:11:06,660 --> 00:11:13,510
+vacculationأب نورمالتي في كرمزوم تلاتة بعمل ميجا
+
+127
+00:11:13,510 --> 00:11:20,210
+كاريوبيسيس وthrombocytosis وهذا غالبا مصحوب بهذا
+
+128
+00:11:20,210 --> 00:11:25,230
+الاب نورمالتي طيب شوف ايديت importance of
+
+129
+00:11:25,230 --> 00:11:28,670
+indication of كرمزوم الاب نورمالتي يقول نمرة واحد
+
+130
+00:11:28,670 --> 00:11:32,270
+to confirm diagnosis نمرة اتنين to know the stage
+
+131
+00:11:32,270 --> 00:11:36,090
+of disease نمرة تلاتة to know the direction of
+
+132
+00:11:36,090 --> 00:11:41,420
+progression of diseaseتطور الحالة المرضية نمرة
+
+133
+00:11:41,420 --> 00:11:45,440
+أربع Multiple Genetic Abnormality معناته المريض في
+
+134
+00:11:45,440 --> 00:11:53,760
+مراحله المتأخرة Pattern of MDS Evolution كيف يتكون
+
+135
+00:11:53,760 --> 00:11:59,340
+هذا المرض و مراحل تكونه جابوا يبدأ ب stable group
+
+136
+00:11:59,340 --> 00:12:02,840
+with no increase in bone marrow blast
+
+137
+00:12:08,420 --> 00:12:10,240
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+138
+00:12:10,240 --> 00:12:16,340
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+139
+00:12:16,340 --> 00:12:19,840
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+140
+00:12:19,840 --> 00:12:19,840
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+141
+00:12:19,840 --> 00:12:20,040
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+142
+00:12:20,040 --> 00:12:20,040
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+143
+00:12:20,040 --> 00:12:20,660
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+144
+00:12:20,660 --> 00:12:23,100
+مضروبة ولكن مستقل والخلايا كانت مضروبة ولكن مستقل
+
+145
+00:12:23,100 --> 00:12:27,720
+والخلايا كانت مضروبة ولكن مستقل والخلايا كانت
+
+146
+00:12:27,720 --> 00:12:33,370
+مضروبة ولكن مستقو .. نمرة تلاتة بيصير في زيادة في
+
+147
+00:12:33,370 --> 00:12:38,630
+ال blast count و .. طبعا حتى في غياب ال
+
+148
+00:12:38,630 --> 00:12:43,310
+cytogenetic changes و هدا هي المراحل المختلفة ده
+
+149
+00:12:43,310 --> 00:12:47,370
+هي normal stem cell لكنها تعرضت ل insult و من ال
+
+150
+00:12:47,370 --> 00:12:51,610
+insult genetic insult ممكن يكون age or viral or
+
+151
+00:12:51,610 --> 00:12:58,690
+chemical or radiochemicalماذا يحصل؟ يحصل فيه
+
+152
+00:12:58,690 --> 00:13:02,910
+Stable New Abnormal Clone Clue abnormal لكنها
+
+153
+00:13:02,910 --> 00:13:05,990
+مازالة مستقلة يعني المريض في هذا الحالة بيكون
+
+154
+00:13:05,990 --> 00:13:12,090
+hematologically silent إذا اتعرض الجينات للـ
+
+155
+00:13:12,090 --> 00:13:16,550
+mutation يحصل في growth advantage و يدخل المريض في
+
+156
+00:13:16,550 --> 00:13:20,420
+مرحلة بيسموها pre-leukemic statusلو فحصنا ال
+
+157
+00:13:20,420 --> 00:13:24,220
+career-type في هذه المرحلة بيلاقيها abnormal يعني
+
+158
+00:13:24,220 --> 00:13:27,740
+قبل هيك بيكون normal او نعم قبل هيك بيكون normal
+
+159
+00:13:27,740 --> 00:13:33,720
+طبعا once career-type is abnormal يعني فيه
+
+160
+00:13:33,720 --> 00:13:36,720
+chromosomal abnormality بيصير فيه inhibition
+
+161
+00:13:36,720 --> 00:13:41,920
+لnormal hemopoiesis وتنتهي غالبا منها بتجلب لمين؟
+
+162
+00:13:41,920 --> 00:13:45,360
+للوكيميا بتجلب للوكيميا بيصير في فلان لوكيميا
+
+163
+00:13:45,360 --> 00:13:50,320
+clone is producedيبقى هذه هي المراحل المختلفة
+
+164
+00:13:50,320 --> 00:13:54,920
+Normal stem cell تعرضت ل install تكوين new
+
+165
+00:13:54,920 --> 00:13:58,580
+abnormal clone لو فحصنا ال proto-oncogen او ال
+
+166
+00:13:58,580 --> 00:14:02,820
+جينات بيكون by karyotyping sorry لكروميزومات by
+
+167
+00:14:02,820 --> 00:14:05,860
+karyotyping بتكون normal ومافي blast cell في هذه
+
+168
+00:14:05,860 --> 00:14:09,300
+الحالة لكن once a mutation is occurred بيصير في
+
+169
+00:14:09,300 --> 00:14:12,960
+growth advantage بيخش المريض في prolaconic status
+
+170
+00:14:12,960 --> 00:14:16,690
+لو فحصنا ال karyotyping على جهة abnormalمتى ما
+
+171
+00:14:16,690 --> 00:14:19,870
+صارت abnormal يعني فيه نهبش لnormal hemopoiesis
+
+172
+00:14:19,870 --> 00:14:25,550
+يعني اللي في الغالب تجلب للوكيميا classification
+
+173
+00:14:25,550 --> 00:14:30,910
+of FAP قسموها إلى خمس أنواع مختلفة هذا الجدول
+
+174
+00:14:30,910 --> 00:14:35,470
+بلخصنا الأنواع المختلفة كلها اللي ان شاء الله
+
+175
+00:14:35,470 --> 00:14:40,310
+بنجيها بالتفصيل قدامي بس هذا الجدول مهم ماشي ايش
+
+176
+00:14:40,310 --> 00:14:43,860
+بيقولالانواع هي خمس انواع Refractory Anemia
+
+177
+00:14:43,860 --> 00:14:46,180
+Refractory Anemia with Ringed Cedroplast
+
+178
+00:14:46,180 --> 00:14:48,800
+Refractory Anemia with Excessive Lust هاي
+
+179
+00:14:48,800 --> 00:14:51,780
+الإختصارات Refractory Anemia with Excessive Lust
+
+180
+00:14:51,780 --> 00:14:52,700
+and Transformation Refractory Anemia with
+
+181
+00:14:52,700 --> 00:14:53,860
+Excessive Lust and Transformation and Chronic
+
+182
+00:14:53,860 --> 00:14:55,400
+Myelomonasitic Leukemia
+
+183
+00:15:04,420 --> 00:15:08,400
+نقدر نشوف الـ Blast في الـ Peripheral Blood و الـ
+
+184
+00:15:08,400 --> 00:15:11,580
+Bone Marrow ثم نشوف الـ Monocytes لإنه في النوع
+
+185
+00:15:11,580 --> 00:15:16,160
+فيه الـ Monocytes ثم Ringed Cedroblast لإنه في
+
+186
+00:15:16,160 --> 00:15:19,560
+النوع بيصير فيه Ringed Cedroblast و نشوف إذا كان
+
+187
+00:15:19,560 --> 00:15:24,000
+فيه other features can be compared فالـ Refractor
+
+188
+00:15:24,000 --> 00:15:26,560
+يقول إن الـ Blast في ال Peripheral Blood يكون أقل
+
+189
+00:15:26,560 --> 00:15:29,580
+من واحد في ال Bone Marrow أقل من خمسة و أنا واحدة
+
+190
+00:15:29,580 --> 00:15:35,750
+عبارة عن Normal Percentageالمنوسية اقل من واحد ال
+
+191
+00:15:35,750 --> 00:15:40,090
+ringcedroblast بتكون اقل من خمستاش و يكون المريض
+
+192
+00:15:40,090 --> 00:15:44,870
+عنده أنيميا انها اللي associated with يعني اللي
+
+193
+00:15:44,870 --> 00:15:48,910
+بيشبهه او تطوره اللي هو النوع التاني اللي هو
+
+194
+00:15:48,910 --> 00:15:53,100
+refractory anemia و ringcedroblastالـ blast يكون
+
+195
+00:15:53,100 --> 00:15:55,720
+أقل من واحد في الـ peripheral blood و أقل من خمسة
+
+196
+00:15:55,720 --> 00:15:59,840
+في البومارو يعني still ال blast لم يتكوّن مانوسايت
+
+197
+00:15:59,840 --> 00:16:05,360
+أيضا كذلك لكن اللي بيميزها وجود ringed cedroblast
+
+198
+00:16:05,360 --> 00:16:09,980
+اسمها with ringed cedroblast ماشي؟ يعني في زيادة
+
+199
+00:16:09,980 --> 00:16:15,340
+في إيش؟ في ال ironهو طبعا في هذا الحالة بيكون في
+
+200
+00:16:15,340 --> 00:16:22,800
+Anemia وفي Refractory Cytopenia لشي بتدي علاج لا
+
+201
+00:16:22,800 --> 00:16:27,740
+يستجيب Refractory Anemia وExcessive Blast هي بدت
+
+202
+00:16:27,740 --> 00:16:31,160
+تزيد ال blast يعني أقل من خمسة في ال peripheral
+
+203
+00:16:31,160 --> 00:16:35,880
+blood من خمسة لعشرين في ال bone marrow يعني لسه
+
+204
+00:16:35,880 --> 00:16:40,280
+ماوصل لتلاتين مايقدرش نسميه leukemia وأقل من واحد
+
+205
+00:16:40,280 --> 00:16:45,440
+ال monocyte أقل من خمستاشراللي هو الـ Sidroblast و
+
+206
+00:16:45,440 --> 00:16:49,960
+الانيم .. و ال .. ال .. طبعا ال other feature اللي
+
+207
+00:16:49,960 --> 00:16:54,000
+هو Cytopenia و Refractory Anemia و الشغلات هذه
+
+208
+00:16:54,000 --> 00:16:58,640
+المواحد الرابع اللي هو Refractory Anemia و Excess
+
+209
+00:16:58,640 --> 00:17:03,780
+Blast in Transformation إيش يعني؟ بدت تقلب فشوفنا
+
+210
+00:17:03,780 --> 00:17:08,250
+ال blast في ال preferable أكتر من خمسةبعد تجربة
+
+211
+00:17:08,250 --> 00:17:12,590
+البرمارو من عشرين لثلاثين يعني تقريبا لكيميا
+
+212
+00:17:12,590 --> 00:17:17,650
+تقريبا في طريقة إلى اللوكيميا يعني خلاص بدأت تجلب
+
+213
+00:17:17,650 --> 00:17:22,450
+in transformation المنو سايت أقل من واحد ring cell
+
+214
+00:17:22,450 --> 00:17:27,110
+plus أقل من خمسة ونبدأ نشوف our body in plus cell
+
+215
+00:17:27,110 --> 00:17:35,360
+وفي زيادة في ال granulocyte countللـ Granulocyte
+
+216
+00:17:35,360 --> 00:17:40,860
+والبرو وطبعا بشكل أساسي Chronic Myelomonasetic
+
+217
+00:17:40,860 --> 00:17:44,880
+leukemia البلاستقال من خمسة ال .. في ال peripheral
+
+218
+00:17:44,880 --> 00:17:49,860
+blood اقل من عشرين في البوماروم و اكتر من واحد لأن
+
+219
+00:17:49,860 --> 00:17:54,940
+هذا هو العامل اللي بيخصها يعني اكتر من الف
+
+220
+00:17:54,940 --> 00:18:01,560
+monocytes في ال peripheral blood وأقل من 15 Ringed
+
+221
+00:18:01,560 --> 00:18:06,160
+Cedroblast وفي زيادة لبرومونو سايتز هذا جدول
+
+222
+00:18:06,160 --> 00:18:09,280
+تقريبا بودح لي الأنواع المختلفة واللي ان شاء الله
+
+223
+00:18:09,280 --> 00:18:14,020
+هنجي إليها دايما بالتفصيل واحد ورا التانية وأول
+
+224
+00:18:14,020 --> 00:18:17,500
+هذي الأنواع اللي هو Refractory Anemia قلنا بيصير
+
+225
+00:18:17,500 --> 00:18:21,300
+فيها by definition dysplasia للارثرويد series only
+
+226
+00:18:21,300 --> 00:18:25,400
+clinically في أنيميا which is refractory to
+
+227
+00:18:25,400 --> 00:18:29,590
+treatment تديها كل المقويات لاستجيب للعلاجميرو
+
+228
+00:18:29,590 --> 00:18:32,790
+بلاستقال من واحد في البريفيرالبلاد وقال من خمسة في
+
+229
+00:18:32,790 --> 00:18:37,190
+البرومارو ومافيش صدروا بلاستقال من خمستاشر ومافيش
+
+230
+00:18:37,190 --> 00:18:42,970
+our root body وكانوا you have to exclude other
+
+231
+00:18:42,970 --> 00:18:50,610
+ideological agents ايش يعني؟ اي أسباب أخرى بتعمل
+
+232
+00:18:50,610 --> 00:18:55,770
+هذه الصورة لازم تستثنيها منها drug or toxin
+
+233
+00:18:55,770 --> 00:18:59,650
+exploderViral Infection, Vitamin Deficiency,
+
+234
+00:19:00,110 --> 00:19:04,090
+Congenital Disease استثناء هذه الشغلات ضد الـ
+
+235
+00:19:04,090 --> 00:19:09,830
+Refractory Anemia هي التشخيص الدنيا تجهي من خمسة
+
+236
+00:19:09,830 --> 00:19:14,190
+لعشر حالات في عشرة في المية من الـ MDS وهي بصيب
+
+237
+00:19:14,190 --> 00:19:18,230
+الإختيارية morphologically بنشوف أنيزو بويكيلو
+
+238
+00:19:18,230 --> 00:19:24,310
+سايتوسز في البرفرالسمين وفي dyserythropoiesis with
+
+239
+00:19:24,310 --> 00:19:28,650
+nuclear abnormalityبنشوف أشهر حاجة ميجالو
+
+240
+00:19:28,650 --> 00:19:33,830
+بلاستويدية changes ميجالو كبير بلاستويد من بلاست
+
+241
+00:19:33,830 --> 00:19:40,390
+ماشي يعني immature changes وهي أقل من 15% ringed
+
+242
+00:19:40,390 --> 00:19:46,850
+cedroblast جناتكس 25% may have genetic abnormality
+
+243
+00:19:46,850 --> 00:19:50,190
+وليه ال diagnosis قالوا بيعيش ال median survival
+
+244
+00:19:50,920 --> 00:19:57,460
+time حوالي 66 شهر لكن 6% منهم بيجلبوا ل acute
+
+245
+00:19:57,460 --> 00:20:02,840
+leukemia بيتطور المرض عندهم to acute leukemia وهذا
+
+246
+00:20:02,840 --> 00:20:08,100
+البرفر السمير أي أنيزو بويكيلو سايتوسي طبعا
+
+247
+00:20:08,100 --> 00:20:10,920
+الانيزو سايتوسي اختلاف الحجوم بويكيلو سايتوسي
+
+248
+00:20:10,920 --> 00:20:15,840
+اختلاف الأشكال وتخيلوا ال bone marrow شايفين كيف
+
+249
+00:20:15,840 --> 00:20:21,900
+الخلايا تتكسر حتى في ال bone marrowوهي بتكون خلايا
+
+250
+00:20:21,900 --> 00:20:26,240
+مشوّة معظم الخلايا اللي موجودة هي عبارة عن خلايا
+
+251
+00:20:26,240 --> 00:20:32,280
+مشوّة وهي ميجالو بلاستويد الـchanges كبيرة لمن؟
+
+252
+00:20:32,280 --> 00:20:41,440
+للخلايا الـRBCs ميجالو بلاستويد تكبر كتير المرة
+
+253
+00:20:41,440 --> 00:20:43,820
+التانية الـrefractor يعني ماهو الـRing سيدروبلاست
+
+254
+00:20:43,820 --> 00:20:46,480
+وهذا بيصير فيه display
+
+255
+00:20:49,160 --> 00:20:52,060
+Clinically, anemia is refractory to hematinic
+
+256
+00:20:52,060 --> 00:20:56,080
+therapy زي الأولاني و نفس الحكاية ال myeloplast في
+
+257
+00:20:56,080 --> 00:20:59,320
+ال preferable blood أقل من خمسة و في ال bone
+
+258
+00:20:59,320 --> 00:21:03,540
+marrow أقل من واحد و أقل من خمسة في ال bone marrow
+
+259
+00:21:03,540 --> 00:21:07,760
+فى شرينج سيدروبلاست وفى شاورو د بادي لكن you have
+
+260
+00:21:07,760 --> 00:21:12,540
+to exclude antituberculosis drug والالكولازيم
+
+261
+00:21:12,540 --> 00:21:16,220
+الدمونولوجي من عشر او اتناش في المية من ال MDS
+
+262
+00:21:16,220 --> 00:21:19,700
+حالات ال MDSو بيسيب الاختيارية و ال males أكتر من
+
+263
+00:21:19,700 --> 00:21:22,700
+ال females و morphologically بنشوف pattern
+
+264
+00:21:22,700 --> 00:21:27,460
+diamorphic يعني شكلين يعني الخلايا لها شكلين on
+
+265
+00:21:27,460 --> 00:21:32,740
+peripheral smears معظم ال RBCs normochromic لكن في
+
+266
+00:21:32,740 --> 00:21:38,340
+second population وهو hypochromic طبعا في this
+
+267
+00:21:38,340 --> 00:21:42,140
+يعني abnormal erythropoiesis في nuclear
+
+268
+00:21:42,140 --> 00:21:46,460
+abnormalities و بنشوف الميجالو blastoid changes
+
+269
+00:21:48,130 --> 00:21:54,430
+مفروض يقل من 15% Ringcedroblast الـ Ringcedroblast
+
+270
+00:21:54,430 --> 00:21:58,130
+هي عبارة عن إيراثرويد الـ precursor cell فيها أكتر
+
+271
+00:21:58,130 --> 00:22:05,170
+من عشرة Sidrotic granules وهذه Sidrotic granules
+
+272
+00:22:05,170 --> 00:22:12,730
+in circling تقريبا تلت أو أكتر من تلت أنواع if
+
+273
+00:22:12,730 --> 00:22:21,080
+excess blast presencethis dictate diagnosis حتى
+
+274
+00:22:21,080 --> 00:22:27,740
+بالرغم من ال percentage of ringed cedroblast ماشي
+
+275
+00:22:27,740 --> 00:22:32,700
+بغض النظر عن وجود ال ringed cedroblast اذا شفنا ال
+
+276
+00:22:32,700 --> 00:22:37,360
+ringed cedroblast اذا شفنا ال blast موجودة هذا على
+
+277
+00:22:37,360 --> 00:22:43,500
+طول بيخلنا نفكر في اتجاه اخر genetically
+
+278
+00:22:45,410 --> 00:22:48,710
+في كلونة او كرمزومة ال abnormality اقل من 10% من
+
+279
+00:22:48,710 --> 00:22:53,550
+الحالات develop such abnormality وبالتالي you have
+
+280
+00:22:53,550 --> 00:22:58,830
+to reassess their diagnoses ال median survival
+
+281
+00:22:58,830 --> 00:23:07,010
+time ست سنوات و 72 شهر و 1-2% من الحالات بيجلب ل
+
+282
+00:23:07,010 --> 00:23:13,170
+acute leukemia و هي ال biomorphic شايفين الشكلين
+
+283
+00:23:13,760 --> 00:23:22,680
+اللي موجودين لل RBCs وهي Ringed Cedroplast كما
+
+284
+00:23:22,680 --> 00:23:27,860
+تشايفين هي Ringed Cedroplast اكتر من تلت الخضية is
+
+285
+00:23:27,860 --> 00:23:34,520
+ringed by cedrotic body وهذا هي Ringed Cedroplast
+
+286
+00:23:36,170 --> 00:23:39,870
+هو الـ megaloblastoid الاختلافات التي نشاهدها في
+
+287
+00:23:39,870 --> 00:23:45,370
+الـ RBC's تكبر و نيكلياسها غير طبيعية و كل شيء
+
+288
+00:23:45,370 --> 00:23:52,250
+فيها غير طبيعي نوع التالت reflector يعني ما with
+
+289
+00:23:52,250 --> 00:23:59,170
+excessive blast ياله by definition هذافي بيكون
+
+290
+00:23:59,170 --> 00:24:03,750
+خمسة لتسعة تاش في المية من ال myeloplast present
+
+291
+00:24:03,750 --> 00:24:07,570
+في ال bone marrow قسموها لنوعين قالوا إذا ال blast
+
+292
+00:24:07,570 --> 00:24:12,590
+من خمسة لتسعة في المية في ال bone marrowوأقل من
+
+293
+00:24:12,590 --> 00:24:15,890
+خمسة في ال blood بيسموها Refractory Anemothesis
+
+294
+00:24:15,890 --> 00:24:20,930
+Blast I وإذا ال blast أقل من عشرة لتسعة عاشر في
+
+295
+00:24:20,930 --> 00:24:25,590
+المية في ال bone marrow وفي أول root body بيسموها
+
+296
+00:24:25,590 --> 00:24:32,510
+Refractory Anemothesis Blast II الدينالوجيا بشكل
+
+297
+00:24:32,510 --> 00:24:36,570
+أربعين في المية من حالات ال MDS بتجيب الاختيارية و
+
+298
+00:24:36,570 --> 00:24:42,800
+morphologicallyفي Dysplasia في كل أنواع الخلايا في
+
+299
+00:24:42,800 --> 00:24:49,380
+نتروفيل أبنرمالتي التي قد تشمل Hypogranulation
+
+300
+00:24:49,380 --> 00:24:55,180
+Hypersegmentation سودو بالكرهوت Anomaly اللي هو
+
+301
+00:24:55,180 --> 00:24:59,740
+عبارة عن Hypersegmentation مع بار بال shape
+
+302
+00:24:59,740 --> 00:25:03,620
+للنكلياس
+
+303
+00:25:03,620 --> 00:25:08,050
+بعدين سودو تشيديا كيجاشي Granulesفي abnormality
+
+304
+00:25:08,050 --> 00:25:11,130
+filigranous of neutrophil ميجا كاريوسايت
+
+305
+00:25:11,130 --> 00:25:14,970
+abnormality ممكن نشوف hybolobulation وممكن نشوف
+
+306
+00:25:14,970 --> 00:25:21,770
+micro ميجا كاريوسايت في هذا النوع ال morphology
+
+307
+00:25:21,770 --> 00:25:26,210
+erythroid glucosal abnormality ممكن نشوف فيها
+
+308
+00:25:26,210 --> 00:25:29,270
+abnormal lobulation ميجا أروبلاستويد and
+
+309
+00:25:29,270 --> 00:25:35,390
+multinucleation وإذا كان الورنة ال myeloblast ممكن
+
+310
+00:25:35,390 --> 00:25:40,870
+تكون من 0 ل19فى ال blood او من خمسة لتسعة عشر فى
+
+311
+00:25:40,870 --> 00:25:46,530
+البورمارو غالبا ال بورمارو is hypercellular فقط
+
+312
+00:25:46,530 --> 00:25:50,110
+عشر لخمستاشر فالمية hypercellular وفى abnormal
+
+313
+00:25:50,110 --> 00:25:55,410
+localization of immature بكاسر اللى هو abnormal
+
+314
+00:25:55,410 --> 00:26:02,780
+localization of immatureprecursor cell may be
+
+315
+00:26:02,780 --> 00:26:07,500
+present المهم في ان خلايا بيكون عصرتها سنة ستاشر
+
+316
+00:26:07,500 --> 00:26:14,640
+تقسيدي تلاتاشر تلاتة و تلاتين ميو سبعتار و النوع
+
+317
+00:26:14,640 --> 00:26:20,480
+الوحيد من ال من ال myelodysplastic syndrome which
+
+318
+00:26:20,480 --> 00:26:27,580
+have relevant phenotype category
+
+319
+00:26:27,580 --> 00:26:33,440
+يعنيGenetic طبعا سجلت حالات كثيرة منها كرموزومة
+
+320
+00:26:33,440 --> 00:26:36,820
+لأبنورماليتي من تلاتين لخمسين في المائة من الحالات
+
+321
+00:26:36,820 --> 00:26:42,540
+Prognosis median survival time لtype one طبعا تاشر
+
+322
+00:26:42,540 --> 00:26:47,480
+شهر وtype two عشر أشهر وخمسة وعشرين في المائة من
+
+323
+00:26:47,480 --> 00:26:50,520
+حالات type one تجلب لالوكيميا بينما تلاتة و تلاتين
+
+324
+00:26:50,520 --> 00:26:56,020
+في المائة من اللي هو type two بجلب لالوكيميا وهي
+
+325
+00:26:56,020 --> 00:27:00,690
+ال hypercellular bone marrow مليان خلائياوهي الـ
+
+326
+00:27:00,690 --> 00:27:08,170
+Blast and hypogranulation اللي موجود وهي
+
+327
+00:27:08,170 --> 00:27:13,210
+ال megaloblastoid اللي ملاحظها with our sorry
+
+328
+00:27:13,210 --> 00:27:16,530
+myeloblast with our root body لإنه بنتحكي على
+
+329
+00:27:16,530 --> 00:27:21,390
+blast the excess blast وهي فيه vacuoles في ال
+
+330
+00:27:21,390 --> 00:27:25,830
+cytoblasm وهي كل ال abnormality بتاعة ال
+
+331
+00:27:25,830 --> 00:27:31,980
+neutrophilسواء كانت Shiryak-Higashi بأنواع مختلفة
+
+332
+00:27:31,980 --> 00:27:35,300
+آخر هذه الأنواع اللي هو Refractory Anemia with
+
+333
+00:27:35,300 --> 00:27:40,660
+excess blast in transformation بشكل
+
+334
+00:27:40,660 --> 00:27:47,960
+21 ل 30% من حالات اللي هو sorry في 21 ل 30% من ال
+
+335
+00:27:47,960 --> 00:27:52,620
+blast في البولمارو و أكتر من 5% blast في ال
+
+336
+00:27:52,620 --> 00:27:56,520
+peripheral blood و في excessive number و mono size
+
+337
+00:27:57,540 --> 00:28:02,040
+وهي normal hyper or hypercellular bone marrow
+
+338
+00:28:02,040 --> 00:28:05,960
+وبيشكل 25% من الحالات
+
+339
+00:28:11,280 --> 00:28:16,020
+اللي هو بيكون فيه خمسة لعشرين فلمية blast في ال
+
+340
+00:28:16,020 --> 00:28:19,880
+bone marrow قل من خمسة فلمية في ال blood stream في
+
+341
+00:28:19,880 --> 00:28:24,960
+cytopenia في at least in at least two line وفي
+
+342
+00:28:24,960 --> 00:28:28,260
+normal or hypercellular bone marrow بشكل خمسة
+
+343
+00:28:28,260 --> 00:28:35,480
+وخمسة عشر لعشرين فلمية من حالات ال MDS IUCMML
+
+344
+00:28:35,480 --> 00:28:40,370
+splenomegalyمايكيلوب popular skin infiltration
+
+345
+00:28:40,370 --> 00:28:46,250
+بيكون في monocytic plural او pericardial effusion
+
+346
+00:28:46,250 --> 00:28:52,210
+وفي جوناع ال myelomonocytic leukemia مرات بيكون في
+
+347
+00:28:52,210 --> 00:28:57,990
+myeloproliferative dysplasia او myelodysplastic
+
+348
+00:28:57,990 --> 00:29:02,070
+syndrome pallor, bleeding, hepatosplenomegaly
+
+349
+00:29:02,070 --> 00:29:03,930
+وskin involvement
+
+350
+00:29:06,850 --> 00:29:13,910
+هذا ما يتعلق بالانواع اللى هو ال myelodysplasia
+
+351
+00:29:13,910 --> 00:29:19,070
+according to FAB classification لكن WHO إجت عملت
+
+352
+00:29:19,070 --> 00:29:24,070
+classification جديد للmyelodysplastic syndrome
+
+353
+00:29:24,070 --> 00:29:29,050
+وجالت لأ احنا الانواع بدنا نقسمها إلى تمان انواع
+
+354
+00:29:29,050 --> 00:29:34,090
+مش خمس انواع زى ما قسموها في الفابأيش الأنواع؟ هو
+
+355
+00:29:34,090 --> 00:29:37,470
+Refractory Anemia و Refractory Anemia with Ringed
+
+356
+00:29:37,470 --> 00:29:41,010
+Cedroblast ثم Refractory Cytopenia with
+
+357
+00:29:41,010 --> 00:29:45,530
+Multilineage Dysplasia و Refractory Cytopenia with
+
+358
+00:29:45,530 --> 00:29:49,770
+Multilineage Dysplasia and Ringed Cedroblast ثم
+
+359
+00:29:49,770 --> 00:29:53,930
+Refractory Anemia with Excessive Blast 1 و 2 ثم
+
+360
+00:29:53,930 --> 00:29:58,630
+Myelodysplastic Syndrome Unclassified مالوش ايه ثم
+
+361
+00:29:58,630 --> 00:30:09,430
+Associated withIsolated deletion of 5EQ.هو يجب أن
+
+362
+00:30:09,430 --> 00:30:12,110
+نقول إن الـ Refractory Anemia مصحوبة عادة
+
+363
+00:30:12,110 --> 00:30:15,730
+بالأنيميا وفي Erythroid dysplasia only، Ringed
+
+364
+00:30:15,730 --> 00:30:19,330
+Cedroblast في أنيميا وفي أكتر من 15% Ringed
+
+365
+00:30:19,330 --> 00:30:22,450
+Cedroblast، Refractory Cytopenia و Multilinear
+
+366
+00:30:22,450 --> 00:30:28,060
+Dysplasia في باي Bad Cytopenia، اتنين.والـ
+
+367
+00:30:28,060 --> 00:30:30,740
+Refractory Cytopenia with Multilinear Dysplasia
+
+368
+00:30:30,740 --> 00:30:34,060
+with Ringed Cedroblast بيكون فيه أكتر من 15%
+
+369
+00:30:34,060 --> 00:30:40,280
+Ringed Cedroblast وExcess Blast 1 بيكون لـ Blast
+
+370
+00:30:40,280 --> 00:30:44,260
+أقل من 5في ال blood واخر من خمسة لتسعة في ال bone
+
+371
+00:30:44,260 --> 00:30:48,500
+marrow وفي اتنين بيكون من خمسة لتسعة عشر في ال
+
+372
+00:30:48,500 --> 00:30:51,540
+peripheral blood ومن عشر لتسعة عشر في ال bone
+
+373
+00:30:51,540 --> 00:30:56,220
+marrow ال unclassified بيكون فيه cytopenia في ال
+
+374
+00:30:56,220 --> 00:31:01,320
+blood وفي myeloid or megakaryocyte dysplasia ال 5Q
+
+375
+00:31:01,320 --> 00:31:07,820
+type بيكون فيه أنميا و .. و بيكونش
+
+376
+00:31:10,480 --> 00:31:16,300
+انيميا ولا في زيادة في الـ Platelet لكن بيكون في
+
+377
+00:31:16,300 --> 00:31:21,720
+ميجا كاريوسيتك
+
+378
+00:31:21,720 --> 00:31:28,680
+Cell with high poly related nuclei أو أقل من 5%
+
+379
+00:31:28,680 --> 00:31:34,210
+بالحصة شو اللي بيقابل اشي في WHO مع الرفاق؟هو الـ
+
+380
+00:31:34,210 --> 00:31:36,790
+Refractory Anemia اللي بيقابلها في الـWHO
+
+381
+00:31:36,790 --> 00:31:39,690
+Refractory Anemia with Refractory Cytopenia with
+
+382
+00:31:39,690 --> 00:31:44,410
+Multilinear Dysplasia 5Q Syndrome Ring Syndrome
+
+383
+00:31:44,410 --> 00:31:53,650
+Blast برضه بيقابلها الرأس ورأس RCMDRS أو الرأس الـ
+
+384
+00:31:53,650 --> 00:31:56,910
+Excessive Blast 1 و2 Transformation with
+
+385
+00:31:56,910 --> 00:32:02,060
+Multilinear Dysplasiaوهي CML وهو myelodysplastic
+
+386
+00:32:02,060 --> 00:32:06,880
+myeloproliferative disease Prognostic group حتى
+
+387
+00:32:06,880 --> 00:32:11,700
+توجه لـ two prognostic group بناء على survival and
+
+388
+00:32:11,700 --> 00:32:17,160
+evolution to acute leukemia تجلب لـ acute leukemia
+
+389
+00:32:17,160 --> 00:32:21,660
+فجاله الجد group الناس اللي بيصير عندهم refractory
+
+390
+00:32:21,660 --> 00:32:25,040
+anemia او refractory anemia with ring cedroblast
+
+391
+00:32:25,040 --> 00:32:29,370
+او FAQ-بينما الـ Body Group هي الـ Refractory
+
+392
+00:32:29,370 --> 00:32:32,010
+Anemia وExcessive Blast وExcessive Blast in
+
+393
+00:32:32,010 --> 00:32:37,490
+Transformation وCMML وهي طبعا النوع التالت اللي هو
+
+394
+00:32:37,490 --> 00:32:43,070
+الـ Unclassified ممكن يكون في group one ولا group
+
+395
+00:32:43,070 --> 00:32:46,450
+two عنده
+
+396
+00:32:46,450 --> 00:32:51,750
+Prognostic Scoring System يعني قطوا Scores لكل
+
+397
+00:32:51,750 --> 00:32:56,750
+نقطة من المقات وبناء على عدد ال Scoresحددوا
+
+398
+00:32:56,750 --> 00:33:03,430
+البروجنوزيز فجأة ال IPSS بيعتمد على percentage of
+
+399
+00:33:03,430 --> 00:33:08,450
+blast على إذا في كرمزومة abnormality ولا لأ وقداش
+
+400
+00:33:08,450 --> 00:33:13,710
+المريض عنده blood count و هدولة بنحطوا score زي ما
+
+401
+00:33:13,710 --> 00:33:17,570
+قلتلكوا كل ما قل ال score كل ما كان جد البروجنوزيز
+
+402
+00:33:18,610 --> 00:33:23,590
+فايل بلاست يوم يكون أقل من خمسة بنعطى صفر لكن صار
+
+403
+00:33:23,590 --> 00:33:28,170
+خمسة لعشرة بسبب بياخد نص إذا كان أكتر من هيك بياخد
+
+404
+00:33:28,170 --> 00:33:32,570
+واحد من أحد عشر لعشرين واحد و نص و هكذا كاريو تايب
+
+405
+00:33:32,570 --> 00:33:37,490
+إذا positive ولا لأ the opinion ماشي إذا من صفر
+
+406
+00:33:37,490 --> 00:33:42,870
+لواحد صفر إذا من اتنين لتلاتة نص و هكذا تجمع هذه
+
+407
+00:33:42,870 --> 00:33:50,100
+الأرقام و كل ما قل الرقم كل ما كانprognosis got
+
+408
+00:33:50,100 --> 00:33:55,080
+differential diagnosis several common diagnostic
+
+409
+00:33:55,080 --> 00:34:02,320
+considerations given these findings طبعا بدك تعمل
+
+410
+00:34:02,320 --> 00:34:06,760
+تستثني عشان تشخص الmyelodysplasia تشخص تستثني
+
+411
+00:34:06,760 --> 00:34:10,920
+الحالات القاتيةنشوف أسباب الـ Bone Marrow Failure
+
+412
+00:34:10,920 --> 00:34:15,020
+الـ Diabetic أو الـ Drug Induced و نشيلها نشوف إذا
+
+413
+00:34:15,020 --> 00:34:20,260
+في Hypersplenism ولا لا ثم إذا في Vitamin B12 و
+
+414
+00:34:20,260 --> 00:34:25,500
+Orpholic Acid Deficiency و حالة الـ PNH ممكن يكون
+
+415
+00:34:25,500 --> 00:34:32,120
+عندها Similar Bone Marrow Finding مع الـ MDS طيب
+
+416
+00:34:32,120 --> 00:34:37,250
+كيف نعمل الـ Differentiation بين الـ Acute Nonالـ
+
+417
+00:34:37,250 --> 00:34:39,570
+Lymphoplastic Leukemia أو الـ Myelodysplasia
+
+418
+00:34:39,570 --> 00:34:50,050
+ببساطة نعمل القاتي من جهة نجيب نعمل
+
+419
+00:34:50,050 --> 00:34:58,310
+برفرة blood ونشوف
+
+420
+00:34:58,310 --> 00:35:06,150
+نسبة الـ Nucleated Cellنسبة الـ RBCs بالنسبة لـ
+
+421
+00:35:06,150 --> 00:35:11,870
+Nucleated Cell طبعا
+
+422
+00:35:11,870 --> 00:35:14,770
+ال .. عفوا احنا بنعمل .. ناخد bone marrow و في هذه
+
+423
+00:35:14,770 --> 00:35:17,690
+الـ bone marrow هي اللي بتحدد ناخد bone marrow و
+
+424
+00:35:17,690 --> 00:35:21,430
+بنتطلع عليه بنشوف نسبة ال RBCs بالنسبة لـ Total
+
+425
+00:35:21,430 --> 00:35:28,370
+Nucleated Cell فإذا كان ال RBCs .. Nucleated RBCs
+
+426
+00:35:28,370 --> 00:35:33,040
+أكتر من 50% بندور، بنشوف جدش فيها Blastولا إذا الـ
+
+427
+00:35:33,040 --> 00:35:38,400
+BLAST أكتر من 30% بيعنيته لوكيميا ومن نوع M6 وإذا
+
+428
+00:35:38,400 --> 00:35:43,120
+كان الـ BLAST أقل من 30% بيعنيته MDS للحالة
+
+429
+00:35:43,120 --> 00:35:49,840
+التانية، نشوف نسبة الـ Nucleated RBCs بالنسبة للـ
+
+430
+00:35:49,840 --> 00:35:53,340
+Nucleated Cell إذا أقل من 50%، ندور على جدّيش فيها
+
+431
+00:35:53,340 --> 00:35:57,960
+BLAST ولا إذا الـ BLAST أكتر من 30% بيعنيته
+
+432
+00:35:57,960 --> 00:36:03,950
+لوكيميا لنوع أخر من اللوكيميا غير M6وإذا كان الـ
+
+433
+00:36:03,950 --> 00:36:09,650
+Plasma أقل من 30% فهي MDS وبهيك بنفرق ما بين الـ
+
+434
+00:36:09,650 --> 00:36:12,790
+Acute Non-Lymphoblastic Leukemia و الـ MDS
+
+435
+00:36:12,790 --> 00:36:20,370
+Pathophysiology أهم حاجة أنه ندور على .. نعرف إيش
+
+436
+00:36:20,370 --> 00:36:23,330
+السبب فالـ Initial Hemopoietic Stem Cell Injury هو
+
+437
+00:36:23,330 --> 00:36:28,290
+السبب وطبعا هذه ممكن تكون due to cytotoxic
+
+438
+00:36:28,290 --> 00:36:33,740
+chemotherapy، radiation، viralو chemical exposure
+
+439
+00:36:33,740 --> 00:36:38,080
+or genetic predisposition الكرونية الميوتيشن اللي
+
+440
+00:36:38,080 --> 00:36:45,620
+بتكوّن over the bone marrow طبعا هو اللي بيشكل ال
+
+441
+00:36:45,620 --> 00:36:50,260
+substance ال healthy stem cell يعني هو اللي بيعيق
+
+442
+00:36:50,260 --> 00:36:56,810
+اللي هو نشاط ال stem cellبالنسبة للبرفيرال بلد
+
+443
+00:36:56,810 --> 00:37:05,070
+البرفيرال البرفيرال
+
+444
+00:37:05,070 --> 00:37:06,710
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+445
+00:37:06,710 --> 00:37:07,550
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+446
+00:37:07,550 --> 00:37:07,550
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+447
+00:37:07,550 --> 00:37:07,650
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+448
+00:37:07,650 --> 00:37:11,410
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+449
+00:37:11,410 --> 00:37:11,410
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+450
+00:37:11,410 --> 00:37:11,410
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+451
+00:37:11,410 --> 00:37:15,950
+البرفيرال البرفيرال البرفيرال البرفيرال البرفيرال
+
+452
+00:37:15,950 --> 00:37:20,990
+الماشي برضه بنعمل cpc و blood film و بنشوف جداش
+
+453
+00:37:20,990 --> 00:37:24,370
+فيه premature RBC فيه عنينيا فيه macrovalocytosis
+
+454
+00:37:24,370 --> 00:37:27,750
+بيسبسه في الاستبلينج و هكذا كل ال abnormality
+
+455
+00:37:27,750 --> 00:37:31,470
+اليوكو ديسبليجيا تشوهت ال white braces برضه
+
+456
+00:37:31,470 --> 00:37:36,390
+بنشوفها و thrombodisplasia أيضا بتدور على
+
+457
+00:37:36,390 --> 00:37:39,530
+thrombocytopenia و اذا كان فيه large or tertiary
+
+458
+00:37:39,530 --> 00:37:43,340
+plateletهذا كلام كله في الـ peripheral blood في
+
+459
+00:37:43,340 --> 00:37:44,920
+الـ bone marrow نعمل نفس الاحكالة
+
+460
+00:37:44,920 --> 00:37:46,880
+erythrodysplasia, leukodysplasia, and
+
+461
+00:37:46,880 --> 00:37:51,640
+thrombodysplasia وهذا هو الجدول الذي يفرق ما بين
+
+462
+00:37:51,640 --> 00:37:56,700
+اللي هو ال peripheral blood و ال bone marrow في
+
+463
+00:37:56,700 --> 00:37:59,700
+الmyelodysplastic syndrome morphological
+
+464
+00:37:59,700 --> 00:38:08,080
+abnormality of اللي هو peripheral blood and bone
+
+465
+00:38:08,080 --> 00:38:12,130
+marrowفي ميليو ديس بلاستيك سندروم وطبعا بين انواع
+
+466
+00:38:12,130 --> 00:38:14,670
+مختلفة من الخلايا اللي هي الارثرويد وميليويد وميكا
+
+467
+00:38:14,670 --> 00:38:18,410
+كاريوسيت و هذا الجدول مش للحفظ لكن ضروري تعرفوا
+
+468
+00:38:18,410 --> 00:38:23,590
+انه فيه تشوهات وانواع هذه التشوهات survival time
+
+469
+00:38:23,590 --> 00:38:28,010
+جاله refractory انيميا بعيش من سنتين لخمس سنوات
+
+470
+00:38:28,010 --> 00:38:31,230
+with ring syndrome blast زي ال refractory انيميا
+
+471
+00:38:31,230 --> 00:38:36,080
+with excessive blastحوالي عشر شهود وهو نمره اتنين
+
+472
+00:38:36,080 --> 00:38:41,580
+و with excess blast in transformation ال survival
+
+473
+00:38:41,580 --> 00:38:48,760
+time is six month or less و طبعا هذه ال median
+
+474
+00:38:48,760 --> 00:38:51,520
+survival time للميلودسبلاستيكس سندرما زي ما انتوا
+
+475
+00:38:51,520 --> 00:38:52,500
+شايفين ده هي
+
+476
+00:38:56,110 --> 00:39:00,750
+النسبة لعدد الأشهر Treatment بيعطوه كيبو ثيرابي و
+
+477
+00:39:00,750 --> 00:39:04,630
+بيعطوه supportive therapy زي ال white PCR بيشيلوا
+
+478
+00:39:04,630 --> 00:39:11,350
+platelet transfusion و في الحالات الصغيرة الشباب
+
+479
+00:39:11,350 --> 00:39:16,590
+يعني بيعملوا bone monotransplantationو يا بيك
+
+480
+00:39:16,590 --> 00:39:21,530
+بنكون أنهينا المحاضرة ال Milo dysplasia ترجوا أن
+
+481
+00:39:21,530 --> 00:39:25,550
+تكونوا قد استفدتم و فهمتم و شكرا
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..aa0298987a14ab48b2ca35572a1944ee7ce28def
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4.srt
@@ -0,0 +1,811 @@
+1
+00:00:04,490 --> 00:00:08,010
+استكملنا في الثلاثيميا موضوع أيضا وهو ال
+
+2
+00:00:08,010 --> 00:00:14,530
+hemoglobinopathies واليوم إن شاء الله هناخد مثال 
+
+3
+00:00:14,530 --> 00:00:19,070
+عن الـ hemoglobinopathies طبعا بداية إحنا عارفين أن
+
+4
+00:00:19,070 --> 00:00:23,670
+أي inherited mutation للـ globin gene بيقدر ال
+
+5
+00:00:23,670 --> 00:00:28,290
+qualitative أو الـ quantitative abnormality إلا الـ
+
+6
+00:00:28,290 --> 00:00:30,870
+quantitative abnormality شفناها في الثلاثيميا
+
+7
+00:00:30,870 --> 00:00:35,600
+بيصير في reduced or complete absent لمين؟ للـ
+
+8
+00:00:35,600 --> 00:00:41,700
+Globin Chain Synthesis بينما الـ qualitative
+
+9
+00:00:41,700 --> 00:00:46,920
+defect اللي هو الـ product بتصير في الـ
+
+10
+00:00:46,920 --> 00:00:52,400
+hemoglobinopathy لإنه أصلا الـ hemoglobin في هذه
+
+11
+00:00:52,400 --> 00:00:56,940
+الحالة بيكون normally produced لكنه abnormal
+
+12
+00:00:56,940 --> 00:01:03,400
+Structural Hemoglobinopathy هو عبارة عن المثال
+
+13
+00:01:03,400 --> 00:01:06,960
+الحقيقي اللي إحنا هنحكي فيه تصير فيه amino acid
+
+14
+00:01:06,960 --> 00:01:11,920
+substitution في الـ globin chain والمثال الحقيقي
+
+15
+00:01:11,920 --> 00:01:15,200
+اللي إحنا هنحكي فيه which is most common هو
+
+16
+00:01:15,200 --> 00:01:23,220
+hemoglobin S قسمه Hemoglobin S defect هيدينا
+
+17
+00:01:23,220 --> 00:01:28,740
+Hemoglobin أو Sickle Cell Anemia حسب الـ mutation
+
+18
+00:01:30,200 --> 00:01:33,460
+إحنا ممكن نشوف homozygous form أو heterozygous
+
+19
+00:01:33,460 --> 00:01:36,720
+form طبعا الـ homozygous form يوم يكون فينا double
+
+20
+00:01:36,720 --> 00:01:41,000
+dose of abnormal gene اللي which encode اللي هو 
+
+21
+00:01:41,000 --> 00:01:45,840
+hemoglobin S والـ heterozygous form لما يكون فيه إنه
+
+22
+00:01:45,840 --> 00:01:52,120
+single اللي هو dose of the abnormal gene which
+
+23
+00:01:52,120 --> 00:01:56,140
+also code for hemoglobin S. Hemoglobin S هو عبارة
+
+24
+00:01:56,140 --> 00:02:00,340
+عن تترامر زي زي الـ normal hemoglobin بيتكون من
+
+25
+00:02:00,340 --> 00:02:07,280
+Alpha to Alpha و to Beta لكن الـ Beta is mutated شو
+
+26
+00:02:07,280 --> 00:02:10,700
+اللي صار فيها جاله فيه amino acid substitution
+
+27
+00:02:10,700 --> 00:02:15,000
+عنده هذا الـ amino acid أصبح الـ Valine محل لـ
+
+28
+00:02:15,000 --> 00:02:19,900
+Glutamine في الـ position رقم ستة ما أفعله؟ طلع
+
+29
+00:02:19,900 --> 00:02:23,560
+لنا بـ Normal Hemoglobin سمينا Hemoglobin S و الـ
+
+30
+00:02:23,560 --> 00:02:27,780
+Hemoglobin S أو في حالة الـ Homozygous Form بيكون
+
+31
+00:02:27,780 --> 00:02:34,160
+SS Hemoglobin SS يعني الاتنين S وبرمجوله Alpha 2
+
+32
+00:02:34,160 --> 00:02:40,190
+Beta 2 6 Gloval يعني أتي بدأ لـ Glutamine Valine أو
+
+33
+00:02:40,190 --> 00:02:45,350
+بيسموه Alpha to Beta to S أو الهيموغلوبين اللي
+
+34
+00:02:45,350 --> 00:02:50,590
+بيسموه Alpha to Beta to 6 Val يعني في الموقع 6 في
+
+35
+00:02:50,590 --> 00:02:58,270
+Valine وهذا عبارة عن فيلم بيوضح لي اللي هو شكل ال
+
+36
+00:02:58,270 --> 00:03:01,510
+sickle cell ده هي عبارة عن crescent shape of
+
+37
+00:03:01,510 --> 00:03:07,670
+RBCs ده هي sickling عبارة عن crescent shape
+
+38
+00:03:07,670 --> 00:03:11,130
+of RBCs طبعا الفيلم بحد ذاته كله abnormal
+
+39
+00:03:11,130 --> 00:03:15,570
+فيه أنيميا واضحة RBCs متباعدة متباعدة من
+
+40
+00:03:15,570 --> 00:03:21,270
+البعض فيه poikilocytosis و anisocytosis يعني هي
+
+41
+00:03:21,270 --> 00:03:28,600
+فيه إنهاش كان فيه crenation Crenated مظهر اه هي في
+
+42
+00:03:28,600 --> 00:03:36,720
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+43
+00:03:36,720 --> 00:03:42,980
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+44
+00:03:42,980 --> 00:03:44,000
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+45
+00:03:44,000 --> 00:03:45,800
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+46
+00:03:45,800 --> 00:03:47,840
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+47
+00:03:47,840 --> 00:03:48,700
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs
+
+48
+00:03:48,700 --> 00:03:48,720
+الـ RBCs الـ RBCs الـ RBCs الـ RBCs الـ RBCs ال
+
+49
+00:03:52,670 --> 00:03:56,030
+في الحالات الطبيعية يعني when properly oxygenated
+
+50
+00:03:56,030 --> 00:04:00,150
+لكن في بعض الحالات لما الـ oxygen tension decrease
+
+51
+00:04:00,150 --> 00:04:04,610
+بيبدأ الـ hemoglobin S 2 polymer عايز و بيبدأ يكون
+
+52
+00:04:04,610 --> 00:04:12,870
+فوق يكون fluid polymer طبعا في هذه الحالات الـ
+
+53
+00:04:12,870 --> 00:04:20,160
+polymers بيصير لها realignment وهذا ما يميز الـ
+
+54
+00:04:20,160 --> 00:04:25,540
+Sickle Shape of RBCs طبعا هذه صورة بالـ
+
+55
+00:04:25,540 --> 00:04:29,060
+Electron Microscope بيبين إنّها Polymerization of
+
+56
+00:04:29,060 --> 00:04:33,960
+Hemoglobin زي ما أنتم شايفين فيه polymers مختلفة
+
+57
+00:04:33,960 --> 00:04:38,360
+بيسموها tactoids بيسموها tactoids طبعا كلها مع بعض
+
+58
+00:04:38,360 --> 00:04:43,320
+تعملاش الـ polymers طبعا this will be rigid و rigid
+
+59
+00:04:43,320 --> 00:04:48,680
+يعني الخلية بطلت deformable وبالتالي بتبدأ تنط
+
+60
+00:04:48,680 --> 00:04:54,920
+الخلية و تاخد شكل الـ polymer اللي تكون فبيصير شكلها
+
+61
+00:04:54,920 --> 00:04:59,660
+crescent shape شايفين الـ polymer الـ fiber فطبعا
+
+62
+00:04:59,660 --> 00:05:08,960
+fiber وده هو micro sectional له hemoglobin s مقطع
+
+63
+00:05:08,960 --> 00:05:13,840
+عرضي طيب شو العوامل اللي بتأدي لها الـ cycling
+
+64
+00:05:13,840 --> 00:05:19,800
+قالوا نوع واحد degree of oxygenation في H
+
+65
+00:05:20,270 --> 00:05:23,170
+dehydration of the patient and the concentration
+
+66
+00:05:23,170 --> 00:05:27,410
+of other hemoglobin كل هذه العوامل لما بتقل بيصير
+
+67
+00:05:27,410 --> 00:05:33,010
+فيه cycling وهذا عبارة عن figure بيبين للقالية الـ
+
+68
+00:05:33,010 --> 00:05:37,590
+cycling process أيه بيزيد الـ cycling ومتيهش لما
+
+69
+00:05:37,590 --> 00:05:42,750
+بصيت كل هذه العوامل اللي قلناها ده هي lower ومبيعش
+
+70
+00:05:42,750 --> 00:05:46,730
+decrease oxygen retention فبيصير فيه إيش increase
+
+71
+00:05:46,730 --> 00:05:50,080
+للـ cycling ده هي cycling طبعا الـ cycling لما بيصير
+
+72
+00:05:50,080 --> 00:05:53,240
+بيصير فيه زيادة في الـ viscosity وإذا زادت الـ
+
+73
+00:05:53,240 --> 00:05:57,820
+viscosity بيصير فيه slow blood circulation بيصير
+
+74
+00:05:57,820 --> 00:06:02,100
+الدم يمشي ببطء وإذا ماشي ببطء بيصير فيه hypoxia و
+
+75
+00:06:02,100 --> 00:06:07,140
+إذا صار فيه hypoxia بيصير فيه cycling وهكذا
+
+76
+00:06:07,140 --> 00:06:13,920
+العملية once started بدها تصير إيش مستمرة
+
+77
+00:06:15,970 --> 00:06:21,110
+obviously of this leads to hypoxia طبعا هذا مصحوبة
+
+78
+00:06:21,110 --> 00:06:28,730
+painful crisis يعني كوارث مؤلمة موجعة and
+
+79
+00:06:28,730 --> 00:06:32,670
+infarction of the organ طبعا أكيد بدّه يصير فيه
+
+80
+00:06:32,670 --> 00:06:35,550
+infarction أنت بتكون تتخيله إنّ الخلية لما بيصير
+
+81
+00:06:35,550 --> 00:06:39,810
+crescent shape وكانها عبارة عن سكاكين بتمشي في
+
+82
+00:06:39,810 --> 00:06:45,860
+الأوعية الدموية وين بتجرح بتغزو إذا و بتجرح وإذا
+
+83
+00:06:45,860 --> 00:06:53,000
+جرحت إذا كان في كميات كبيرة منها إحنا ممكن تجرح
+
+84
+00:06:53,000 --> 00:06:58,520
+الأعضاء أو اللي بتمر فيها بشكل أكبر وبالتالي ممكن
+
+85
+00:06:58,520 --> 00:07:02,020
+تؤدي لـ infraction of the organ
+
+86
+00:07:05,420 --> 00:07:09,220
+طبعا لازم نعرف إنّ إذا كان كل ما زادت الـ
+
+87
+00:07:09,220 --> 00:07:11,700
+concentration of Hemoglobin E و Hemoglobin F كل ما
+
+88
+00:07:11,700 --> 00:07:15,780
+كانت الحالة الـ severity of the disease is lowered
+
+89
+00:07:15,780 --> 00:07:19,140
+عشان
+
+90
+00:07:19,140 --> 00:07:22,220
+هيك فيها حالات من هالنوع بيعملوا عملية نقل دم
+
+91
+00:07:22,220 --> 00:07:27,720
+أثناء الـ crisis فبيغيروا دمه من Sickle إلى Normal
+
+92
+00:07:27,720 --> 00:07:33,700
+Hemoglobin clinical picture الأعراض في الـ sickle
+
+93
+00:07:33,700 --> 00:07:40,400
+cell الانيميا are seldom manifested لما بنتشوفها
+
+94
+00:07:40,400 --> 00:07:45,120
+قبل سن ست سنوات أو ست شهور بعد الولادة السبب في
+
+95
+00:07:45,120 --> 00:07:47,620
+ذلك إنّ في هذه الفترة بيكون الـ hemoglobin هو عبارة
+
+96
+00:07:47,620 --> 00:07:52,620
+عن hemoglobin F ولسه ما صارش shifting من الـ F للـ A
+
+97
+00:07:53,310 --> 00:08:00,150
+اللي فيه Beta وبالتالي الـ symptoms
+
+98
+00:08:00,150 --> 00:08:06,270
+بتكون obscure مخبئ يعني الـ condition بعد هي بتميز
+
+99
+00:08:06,270 --> 00:08:09,430
+الـ characterize chronic hemolytic status و
+
+100
+00:08:09,430 --> 00:08:13,290
+jaundice والـ hemoglobin بتكون في حدود 7 على 8
+
+101
+00:08:13,290 --> 00:08:20,050
+gram clinical picture مريض ثلاثيميا Sickle
+
+102
+00:08:20,050 --> 00:08:26,430
+الانيميا sorry بيعاني من التالي stomach arm و leg
+
+103
+00:08:26,430 --> 00:08:31,770
+and joint pain ألم في كل أنحاء الجسم tired تعبان
+
+104
+00:08:31,770 --> 00:08:38,240
+tense متوتر and nervous عصبي طبيعي جدا واحد بيمشي
+
+105
+00:08:38,240 --> 00:08:42,540
+في دمه سكاكين بده يكون بهالوضع هذا short trunk هذا
+
+106
+00:08:42,540 --> 00:08:48,200
+اللي هو يقصد يعني شكل خاص short trunk يعني الجزء
+
+107
+00:08:48,200 --> 00:08:55,340
+العلوي منه بيكون قليل قصير و ulcer الـ leg بيصير
+
+108
+00:08:55,340 --> 00:09:01,860
+فيه قرحات وفي الـ thumb arm بيصير وشكل رأسه
+
+109
+00:09:01,860 --> 00:09:03,380
+بيسموه tower shape head
+
+110
+00:09:06,020 --> 00:09:10,020
+in large in large level and higher طبيعي جدا بيصير
+
+111
+00:09:10,020 --> 00:09:15,080
+فيه اللي هو extra
+
+112
+00:09:15,080 --> 00:09:20,020
+medullary خصوصا إذا كان الـ during a crisis
+
+113
+00:09:20,020 --> 00:09:24,200
+complications لو بيصير فيه acute chest syndrome
+
+114
+00:09:24,200 --> 00:09:27,820
+خصوصا سببها infection إنّ الـ lung will be trapped
+
+115
+00:09:27,820 --> 00:09:33,680
+with RBCs أو الـ RBCs بصلاها trapping في الـ lung
+
+116
+00:09:33,680 --> 00:09:35,620
+العنينية 
+
+117
+00:09:37,480 --> 00:09:41,180
+aplastic crisis في لحظة من اللحظات بيصير في
+
+118
+00:09:41,180 --> 00:09:45,760
+temporary يعني مؤقت lack of RBCs production
+
+119
+00:09:45,760 --> 00:09:51,540
+و bone necrosis بيصير فيه degradation للبون وهذا
+
+120
+00:09:51,540 --> 00:09:54,800
+بيؤدي بعض مرات لـ hip replacement و other
+
+121
+00:09:54,800 --> 00:10:01,540
+complications طريقة مفصل hand and foot syndrome
+
+122
+00:10:01,540 --> 00:10:05,320
+hand في أطراف اليد والرجلين بيصير في painful
+
+123
+00:10:05,320 --> 00:10:10,670
+swelling فيهم لإنه بيصير فيه تجمع لكميات كبيرة من
+
+124
+00:10:10,670 --> 00:10:15,810
+الـ sickle cell بيصير فيه severe infection و sepsis
+
+125
+00:10:15,810 --> 00:10:22,730
+خصوصا بيصير فيه septicemia يعني و sepsis وهي بيصير
+
+126
+00:10:22,730 --> 00:10:27,290
+meningitis نيومونيا و risk of infection is
+
+127
+00:10:27,290 --> 00:10:32,430
+increased كل ما كان الـ spleen
+
+128
+00:10:34,870 --> 00:10:39,270
+يعني مصعب أكثر splenic sequestration crisis شو
+
+129
+00:10:39,270 --> 00:10:44,630
+يعني sequestration تبدأ عملية بلع splenic لـ spleen
+
+130
+00:10:44,630 --> 00:10:50,970
+بيبدأ يعمل عملية بلع لكميات كبيرة من الـ sickle cell
+
+131
+00:10:50,970 --> 00:10:53,410
+مرة واحدة عشان يخلصنا منها لأنها كلها abnormal
+
+132
+00:10:53,410 --> 00:10:58,790
+فبيصير في .. لما بيبلع كمية كبيرة لـ spleen بيصير له
+
+133
+00:10:58,790 --> 00:11:04,290
+فرشن وسمّوه لعملية auto auto يعني ذاتي splenectomy
+
+134
+00:11:05,780 --> 00:11:10,660
+Stroke وصلت الـ sickle cell للدماغ تعمل stroke جلطة
+
+135
+00:11:10,660 --> 00:11:16,160
+دماغية والـ sign عبارة عن scissor اللي هو
+
+136
+00:11:16,160 --> 00:11:22,620
+تشنجات و weakness in the arm and leg speech
+
+137
+00:11:22,620 --> 00:11:28,780
+problem and loss of consciousness الحالة الثانية
+
+138
+00:11:28,780 --> 00:11:32,980
+Sickle cell trait إنّه بيكون جين من الاثنين هو المصاب
+
+139
+00:11:32,980 --> 00:11:38,460
+وبيسمّوا الحالة Alpha 2 Beta 1 Beta 1 6 Global و
+
+140
+00:11:38,460 --> 00:11:41,360
+المريض في هذه الحالة بيفكر إنّه هو اللي مجرد بيناس ال
+
+141
+00:11:41,360 --> 00:11:45,300
+trait بيكون غالباً asymptomatic ما لم يتعرض إلى
+
+142
+00:11:45,300 --> 00:11:50,600
+challenge ماشي ومن ال challenge اللي ممكن يتعرض 
+
+143
+00:11:50,600 --> 00:11:54,330
+اليها اللي هو drafting lowering of gauge زي
+
+144
+00:11:54,330 --> 00:11:58,850
+Respiratory Acidosis Reduction in Oxygen Tension
+
+145
+00:11:58,850 --> 00:12:06,190
+بيقلّي بشكل فظيع جداً زي ما في حالة ايش اللي ده هو
+
+146
+00:12:06,190 --> 00:12:10,690
+السفر بـ Unpressurized aircraft اليوم حلوها طبعاً كل
+
+147
+00:12:10,690 --> 00:12:14,970
+الطيران هو عبارة عن Pressurized Anesthesia إذا 
+
+148
+00:12:14,970 --> 00:12:19,530
+تعرض إلى التخدير صار فيه Hypoxia و Congestive
+
+149
+00:12:19,530 --> 00:12:24,510
+Heart Failure برضه Hypoxia excessive exercise ممكن
+
+150
+00:12:24,510 --> 00:12:31,230
+يؤدي إلى زيادة في تجمع ال lactic acid يعني acidosis
+
+151
+00:12:31,230 --> 00:12:36,510
+والـ laboratory
+
+152
+00:12:36,510 --> 00:12:42,350
+finding طبعاً تنقسم إلى هنحكي على جزئين sickle cell
+
+153
+00:12:42,350 --> 00:12:45,230
+anemia و sickle cell trait فالـ sickle cell anemia
+
+154
+00:12:45,230 --> 00:12:49,610
+الـ blood film هو برعان نورمو سايتيك نورمو كروميك و
+
+155
+00:12:49,610 --> 00:12:55,160
+الـ anemia is نورمو سايتيك نورمو كروميك تيمونه بالليل 
+
+156
+00:12:55,160 --> 00:13:00,520
+بوصل من ستة لتمانية وبنشوف القاعدي لو في الـ blood 
+
+157
+00:13:00,520 --> 00:13:06,400
+film numerous target cell و fragmented RBCs و
+
+158
+00:13:06,400 --> 00:13:10,960
+polychromasia نيكليتد RBCs sickle cell is common
+
+159
+00:13:10,960 --> 00:13:14,940
+نحكي عن sickle cell أنيميا التي كيلو سايت عالي من
+
+160
+00:13:14,940 --> 00:13:21,390
+خمسة لعشرين لأن في hemolysis لكن بتقلّ during crisis
+
+161
+00:13:21,390 --> 00:13:27,030
+aplastic crisis leukocytosis و thrombocytosis is 
+
+162
+00:13:27,030 --> 00:13:31,630
+common الـ bone marrow reflects مرض ايراثرويد
+
+163
+00:13:31,630 --> 00:13:37,710
+hyperplasia بيكون مليان برضه معدي during a crisis
+
+164
+00:13:37,710 --> 00:13:42,910
+كيف بنشخص؟ قالوا فيه فحصين الأول يسمى solubility
+
+165
+00:13:42,910 --> 00:13:46,930
+test فيه special tube بترسب فيها ال hemoglobin s
+
+166
+00:13:46,930 --> 00:13:52,290
+فقط الـ hemoglobin s الحاجة الثانية sodium 
+
+167
+00:13:52,290 --> 00:13:56,870
+metabisulfite test وده إن شاء الله ده هتشتغله في
+
+168
+00:13:56,870 --> 00:14:02,320
+الاتنين في المعامل بالنسبة لـ Screening Test قديم
+
+169
+00:14:02,320 --> 00:14:09,180
+بيستخدم فيه Sodium Metasilphide اللي بتعمل Cycling
+
+170
+00:14:09,180 --> 00:14:14,380
+Induction لأنها بتعمل Hypoxia وبالتالي بيصير فيه
+
+171
+00:14:14,380 --> 00:14:18,140
+Cycling ومهم جداً أن أعرف أنه في other types of
+
+172
+00:14:18,140 --> 00:14:21,340
+Hemoglobin ممكن يصير له Cycling زي الـ Hemoglobin C
+
+173
+00:14:21,340 --> 00:14:26,640
+في هذا الفحص لكن الفحص الأكيد هو الـ hemoglobin
+
+174
+00:14:26,640 --> 00:14:30,440
+electrophoresis طبعاً في حالات الـ sickles الانيميا
+
+175
+00:14:30,440 --> 00:14:36,480
+الـ hemoglobin F يكون 80% والـ hemoglobin F 20% و
+
+176
+00:14:36,480 --> 00:14:41,680
+طبعاً الـ hemoglobin F كل ما زاد كل ما قلّل الـ
+
+177
+00:14:41,680 --> 00:14:47,280
+severity of years of cycling وده بنشوفه في الـ
+
+178
+00:14:47,280 --> 00:14:51,160
+newborn يوم يكون عندنا الـ Hemoglobin F عالي كتير
+
+179
+00:14:51,160 --> 00:14:55,540
+مريض بعانيش كمان بتشوفه في حالة ثانية اسمها
+
+180
+00:14:55,540 --> 00:14:58,960
+Hereditary Resistance of Fetal Hemoglobin ما بيصير 
+
+181
+00:14:58,960 --> 00:15:03,260
+في هذه الحالة بيصيرش فيها shifting من Hemoglobin F 
+
+182
+00:15:03,260 --> 00:15:08,840
+لـ Hemoglobin A وطبعاً في كل الحالات كل الحالات بكون
+
+183
+00:15:08,840 --> 00:15:13,580
+الـ hemoglobin A2 عالي أما sickle cell trait prefer 
+
+184
+00:15:13,580 --> 00:15:17,900
+blood smear usually normal مع ده شوية target cell
+
+185
+00:15:17,900 --> 00:15:26,960
+و solubility و الـ screening test is positive والـ
+
+186
+00:15:26,960 --> 00:15:30,180
+electrophoresis بيكون احنا فيه انا اتنين هالجيه ده
+
+187
+00:15:30,180 --> 00:15:34,980
+hemoglobin A 60% hemoglobin A 40% والـ hemoglobin A2
+
+188
+00:15:34,980 --> 00:15:41,300
+is elevated سكل لو عملنا blood film بنشوفهاش ما لم
+
+189
+00:15:41,300 --> 00:15:48,180
+يكن في Crisis treatment بتعتمد على حاجتين في
+
+190
+00:15:48,180 --> 00:15:53,960
+الحاجة الأولانية أنك تتوعي المريض تفهم المريض أنه
+
+191
+00:15:53,960 --> 00:16:02,160
+ما يتعرض إلى مسببات الـ سكل يعني لازم يبعد عن الـ
+
+192
+00:16:02,160 --> 00:16:05,080
+hypoxic condition عن الـ dehydration عن الـ
+
+193
+00:16:05,080 --> 00:16:10,520
+infection كلها هذه بتعمل Cycling crisis يبعد عنها
+
+194
+00:16:10,520 --> 00:16:14,720
+يتجنبها الحاجة الثانية الـ temporary treatment شو
+
+195
+00:16:14,720 --> 00:16:19,280
+بيعملوا قالوا إذا المريض يحتاج أنه يعدي مرحلة
+
+196
+00:16:19,280 --> 00:16:23,070
+معينة زي في حالة الـ pregnancy أو إذا بدوا يخشوا
+
+197
+00:16:23,070 --> 00:16:26,750
+يعملوا عملية بيروحوا وهم عاملين hyper transfusion
+
+198
+00:16:26,750 --> 00:16:32,730
+بدوا واحدة دم ماشي نستبدل من خلالها اللي هو
+
+199
+00:16:32,730 --> 00:16:38,810
+hemoglobin s أو secret RBCs abnormal RBCs it's a
+
+200
+00:16:38,810 --> 00:16:40,050
+temporary treatment
+
+201
+00:16:42,390 --> 00:16:47,130
+يعني بهيك بكون إن شاء الله رويت الـ sickle cell وأن
+
+202
+00:16:47,130 --> 00:16:51,650
+شاء الله بكونوا استفدتوا أيضاً من ايش من هذه
+
+203
+00:16:51,650 --> 00:16:53,350
+المحاضرة شكراً 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c25e362aa8019a826e9db203ab7e3f5489ad28be
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/DsI6MicbEp4_raw.json
@@ -0,0 +1 @@
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Alpha", "probability": 0.95849609375}, {"start": 121.86, "end": 122.62, "word": " و", "probability": 0.8486328125}, {"start": 122.62, "end": 122.74, "word": " to", "probability": 0.51220703125}, {"start": 122.74, "end": 123.12, "word": " Beta", "probability": 0.86328125}, {"start": 123.12, "end": 124.4, "word": " لكن", "probability": 0.77783203125}, {"start": 124.4, "end": 124.72, "word": " ال", "probability": 0.98095703125}, {"start": 124.72, "end": 125.14, "word": " Beta", "probability": 0.63232421875}, {"start": 125.14, "end": 126.32, "word": " is", "probability": 0.935546875}, {"start": 126.32, "end": 126.98, "word": " mutated", "probability": 0.912353515625}, {"start": 126.98, "end": 127.28, "word": " شو", "probability": 0.6993408203125}, {"start": 127.28, "end": 127.4, "word": " اللي", "probability": 0.978759765625}, {"start": 127.4, "end": 127.66, "word": " صار", "probability": 0.978271484375}, {"start": 127.66, "end": 128.16, "word": " فيها", "probability": 0.985107421875}, 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Hemoglobin S و الـ Hemoglobin S أو في حالة الـ Homozygous Form بيكون SS Hemoglobin SS يعني الاتنين S وبرمجوله Alpha 2 Beta 2 6 Gloval يعني أتي بدأ لـ Glutamine Valine", "tokens": [10721, 9381, 49628, 2423, 39184, 7188, 533, 3714, 5016, 1211, 5296, 39184, 5209, 325, 18929, 8978, 2423, 39184, 2535, 12602, 4587, 2304, 8608, 2655, 3660, 19446, 5551, 5172, 30241, 3224, 22807, 23032, 1211, 3615, 5296, 8315, 4724, 39184, 21277, 18568, 45841, 13496, 8608, 2304, 1829, 8315, 18568, 45841, 13496, 318, 4032, 2423, 39184, 18568, 45841, 13496, 318, 34051, 8978, 11331, 6027, 3660, 2423, 39184, 389, 13395, 1229, 70, 563, 10126, 4724, 1829, 30544, 12238, 18568, 45841, 13496, 12238, 37495, 22653, 2423, 9307, 1863, 9957, 318, 4032, 26890, 2304, 7435, 12610, 3224, 20588, 568, 33286, 568, 1386, 10786, 3337, 37495, 22653, 5551, 31371, 47525, 10721, 5296, 39184, 5209, 325, 18929, 7188, 533], "avg_logprob": -0.438616061050977, "compression_ratio": 1.5381355932203389, "no_speech_prob": 0.0, "words": [{"start": 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{"start": 394.63, "end": 395.03, "word": " الخلية", "probability": 0.8118489583333334}, {"start": 395.03, "end": 395.23, "word": " لما", "probability": 0.5848388671875}, {"start": 395.23, "end": 395.55, "word": " بصير", "probability": 0.5504150390625}, {"start": 395.55, "end": 396.09, "word": " crescent", "probability": 0.778564453125}, {"start": 396.09, "end": 396.83, "word": " انشيب", "probability": 0.5987548828125}, {"start": 396.83, "end": 397.67, "word": " وكانها", "probability": 0.859375}, {"start": 397.67, "end": 398.01, "word": " عبارة", "probability": 0.9656982421875}, {"start": 398.01, "end": 398.21, "word": " عن", "probability": 0.9921875}, {"start": 398.21, "end": 399.01, "word": " سكاكين", "probability": 0.7890625}, {"start": 399.01, "end": 399.67, "word": " بتمشي", "probability": 0.84674072265625}, {"start": 399.67, "end": 399.81, "word": " في", "probability": 0.91015625}, {"start": 399.81, "end": 400.11, "word": " القوية", "probability": 0.5652669270833334}, {"start": 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"word": " كميات", "probability": 0.97802734375}, {"start": 407.72, "end": 408.18, "word": " كبيرة", "probability": 0.97705078125}, {"start": 408.18, "end": 408.88, "word": " منها", "probability": 0.991455078125}, {"start": 408.88, "end": 409.48, "word": " مانتو", "probability": 0.493804931640625}, {"start": 409.48, "end": 409.94, "word": " ممكن", "probability": 0.85009765625}, {"start": 409.94, "end": 413.0, "word": " تجرح", "probability": 0.8875732421875}, {"start": 413.0, "end": 413.86, "word": " الأعضاء", "probability": 0.9688720703125}, {"start": 413.86, "end": 414.26, "word": " أو", "probability": 0.434814453125}, {"start": 414.26, "end": 414.98, "word": " اللي", "probability": 0.797119140625}, {"start": 414.98, "end": 415.34, "word": " بتمر", "probability": 0.88134765625}, {"start": 415.34, "end": 415.78, "word": " فيها", "probability": 0.98388671875}, {"start": 415.78, "end": 416.96, "word": " بشكل", "probability": 0.9921875}, {"start": 416.96, "end": 417.68, "word": " أكبر", 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lowered عشان هيك فيها حالات من هالنوع بيعملوا عملية نقل دم أثناء ال crisis فبيغيروا دمه من Sickle الى Normal Hemoglobin", "tokens": [9566, 3555, 3615, 995, 5296, 31377, 2304, 8717, 3615, 28480, 16472, 1975, 15730, 25961, 28242, 19446, 30767, 18513, 2655, 2423, 9856, 295, 18568, 45841, 13496, 462, 4032, 18568, 45841, 13496, 479, 28242, 19446, 25961, 2655, 21542, 6027, 3660, 2423, 35179, 295, 264, 4752, 307, 28466, 6225, 8592, 7649, 39896, 4117, 8978, 11296, 11331, 6027, 9307, 9154, 8032, 6027, 1863, 45367, 4724, 1829, 25957, 1211, 14407, 6225, 42213, 10632, 8717, 4587, 1211, 11778, 2304, 5551, 12984, 1863, 16606, 2423, 5869, 6156, 21292, 17082, 13546, 14407, 11778, 2304, 3224, 9154, 43471, 306, 2423, 7578, 21277, 18568, 45841, 13496], "avg_logprob": -0.2224549018230635, "compression_ratio": 1.5188284518828452, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 425.42, "end": 426.12, "word": "طبعا", "probability": 0.7750244140625}, {"start": 426.12, "end": 426.82, "word": " 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الولادة السبب في ذلك انه في هذه الفترة بيكون ال hemoglobin هو عبارة عن hemoglobin F و لسه ماصارش shifting من ال F للA", "tokens": [3474, 259, 804, 3036, 42963, 3615, 2288, 46958, 8978, 2423, 4998, 306, 2815, 2423, 7649, 32640, 25528, 366, 47717, 42775, 5296, 15042, 4724, 29399, 8592, 38688, 11296, 12174, 36150, 8608, 1863, 8608, 2655, 8608, 1863, 2407, 9307, 1975, 2407, 8608, 2655, 13412, 3224, 13063, 39182, 2423, 12610, 18513, 3660, 21136, 3555, 3555, 8978, 29910, 23275, 16472, 3224, 8978, 29538, 27188, 2655, 25720, 4724, 1829, 30544, 2423, 8636, 45841, 13496, 31439, 6225, 3555, 9640, 3660, 18871, 8636, 45841, 13496, 479, 4032, 5296, 3794, 3224, 19446, 9381, 9640, 8592, 17573, 9154, 2423, 479, 24976, 32], "avg_logprob": -0.2930518623362196, "compression_ratio": 1.56, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 449.36, "end": 449.9, "word": "clinical", "probability": 0.6546630859375}, {"start": 449.9, "end": 450.36, "word": " picture", "probability": 0.8271484375}, 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"probability": 0.92529296875}, {"start": 465.7, "end": 465.92, "word": " هذه", "probability": 0.71728515625}, {"start": 465.92, "end": 466.34, "word": " الفترة", "probability": 0.9923502604166666}, {"start": 466.34, "end": 466.66, "word": " بيكون", "probability": 0.817138671875}, {"start": 466.66, "end": 466.74, "word": " ال", "probability": 0.84423828125}, {"start": 466.74, "end": 467.22, "word": " hemoglobin", "probability": 0.7740071614583334}, {"start": 467.22, "end": 467.38, "word": " هو", "probability": 0.82763671875}, {"start": 467.38, "end": 467.62, "word": " عبارة", "probability": 0.9393310546875}, {"start": 467.62, "end": 467.72, "word": " عن", "probability": 0.96240234375}, {"start": 467.72, "end": 468.22, "word": " hemoglobin", "probability": 0.8704427083333334}, {"start": 468.22, "end": 468.5, "word": " F", "probability": 0.703125}, {"start": 468.5, "end": 469.14, "word": " و", "probability": 0.875}, {"start": 469.14, "end": 469.38, "word": " لسه", "probability": 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الانيميا ال hemoglobin F يكون 80% و ال hemoglobin F 20% و طبعا ال hemoglobin F كل ما زاد كل ما قلل ال severity of years of cycling و ده بنشوفه في ال newborn", "tokens": [1211, 19452, 27188, 5016, 9381, 42963, 4117, 25708, 31439, 2423, 8636, 45841, 13496, 2185, 11741, 2706, 271, 23032, 3555, 3615, 995, 8978, 11331, 6027, 9307, 2423, 4998, 904, 2423, 7649, 32640, 25528, 2423, 8636, 45841, 13496, 479, 7251, 30544, 4688, 4, 4032, 2423, 8636, 45841, 13496, 479, 945, 4, 4032, 23032, 3555, 3615, 995, 2423, 8636, 45841, 13496, 479, 28242, 19446, 30767, 18513, 28242, 19446, 12174, 1211, 1211, 2423, 35179, 295, 924, 295, 22425, 4032, 11778, 3224, 44945, 8592, 38688, 3224, 8978, 2423, 32928], "avg_logprob": -0.23713234663009644, "compression_ratio": 1.598984771573604, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 862.78, "end": 863.68, "word": "لكن", "probability": 0.68359375}, {"start": 863.68, "end": 864.34, "word": " الفحص", "probability": 0.9378255208333334}, {"start": 864.34, "end": 865.02, "word": " الاكيد", "probability": 0.77490234375}, {"start": 865.02, "end": 865.7, "word": " هو", "probability": 0.92626953125}, {"start": 865.7, "end": 866.16, "word": " ال", "probability": 0.67041015625}, {"start": 866.16, "end": 866.64, "word": " hemoglobin", "probability": 0.8097330729166666}, {"start": 866.64, "end": 867.72, "word": " electrophoresis", "probability": 0.871826171875}, {"start": 867.72, "end": 868.42, "word": " طبعا", "probability": 0.905517578125}, {"start": 868.42, "end": 868.54, "word": " في", "probability": 0.81591796875}, {"start": 868.54, "end": 868.94, "word": " حالات", "probability": 0.9669596354166666}, {"start": 868.94, "end": 869.16, "word": " ال", "probability": 0.69189453125}, {"start": 869.16, "end": 869.72, "word": " sickles", "probability": 0.48565673828125}, {"start": 869.72, "end": 870.44, "word": " الانيميا", "probability": 0.6953125}, {"start": 870.44, "end": 870.76, "word": " ال", "probability": 0.92431640625}, {"start": 870.76, "end": 871.24, "word": " hemoglobin", "probability": 0.89794921875}, {"start": 871.24, "end": 871.42, "word": " F", "probability": 0.34033203125}, {"start": 871.42, "end": 871.7, "word": " يكون", "probability": 0.50244140625}, {"start": 871.7, "end": 872.1, "word": " 80", "probability": 0.48876953125}, {"start": 872.1, "end": 872.54, "word": "%", "probability": 0.96533203125}, {"start": 872.54, "end": 872.84, "word": " و", "probability": 0.794921875}, {"start": 872.84, "end": 873.64, "word": " ال", "probability": 0.62841796875}, {"start": 873.64, "end": 874.14, "word": " hemoglobin", "probability": 0.93505859375}, {"start": 874.14, "end": 874.4, "word": " F", "probability": 0.8818359375}, {"start": 874.4, "end": 874.96, "word": " 20", "probability": 0.68408203125}, {"start": 874.96, "end": 876.16, "word": "%", "probability": 0.85205078125}, {"start": 876.16, "end": 876.48, "word": " و", "probability": 0.84619140625}, {"start": 876.48, "end": 877.08, "word": " طبعا", "probability": 0.93896484375}, {"start": 877.08, "end": 878.5, "word": " ال", "probability": 0.9765625}, {"start": 878.5, "end": 879.04, "word": " hemoglobin", "probability": 0.9475911458333334}, {"start": 879.04, "end": 879.44, "word": " F", "probability": 0.978515625}, {"start": 879.44, "end": 879.86, "word": " كل", "probability": 0.91650390625}, {"start": 879.86, "end": 880.08, "word": " ما", "probability": 0.73095703125}, {"start": 880.08, "end": 880.6, "word": " زاد", "probability": 0.945068359375}, {"start": 880.6, "end": 880.86, "word": " كل", "probability": 0.87451171875}, {"start": 880.86, "end": 881.1, "word": " ما", "probability": 0.90673828125}, {"start": 881.1, "end": 881.52, "word": " قلل", "probability": 0.797607421875}, {"start": 881.52, "end": 881.68, "word": " ال", "probability": 0.71533203125}, {"start": 881.68, "end": 882.16, "word": " severity", "probability": 0.99658203125}, {"start": 882.16, "end": 882.48, "word": " of", "probability": 0.9296875}, {"start": 882.48, "end": 882.84, "word": " years", "probability": 0.533203125}, {"start": 882.84, "end": 883.94, "word": " of", "probability": 0.96630859375}, {"start": 883.94, "end": 884.5, "word": " cycling", "probability": 0.68896484375}, {"start": 884.5, "end": 886.42, "word": " و", "probability": 0.8837890625}, {"start": 886.42, "end": 886.52, "word": " ده", "probability": 0.8779296875}, {"start": 886.52, "end": 887.06, "word": " بنشوفه", "probability": 0.899658203125}, {"start": 887.06, "end": 887.18, "word": " في", "probability": 0.86962890625}, {"start": 887.18, "end": 887.28, "word": " ال", "probability": 0.908203125}, {"start": 887.28, "end": 887.6, "word": " newborn", "probability": 0.459716796875}], "temperature": 1.0}, {"id": 36, "seek": 90470, "start": 888.62, "end": 904.7, "text": "يوم يكون عندنا ال Hemoglobin F عالي كتير مغيد بعانيش كمان بتشوفه في حالة تانية اسمها Hereditary Resistance of Fetal Hemoglobin ما بيصير في هذه الحالة بيصيرش فيها shifting من Hemoglobin F لHemoglobin A", "tokens": [1829, 20498, 7251, 30544, 43242, 8315, 2423, 18568, 45841, 13496, 479, 6225, 6027, 1829, 9122, 2655, 13546, 3714, 17082, 25708, 45030, 7649, 1829, 8592, 9122, 2304, 7649, 39894, 8592, 38688, 3224, 8978, 11331, 6027, 3660, 6055, 7649, 10632, 24525, 2304, 11296, 3204, 292, 4109, 45647, 295, 479, 302, 304, 18568, 45841, 13496, 19446, 4724, 1829, 9381, 13546, 8978, 29538, 21542, 6027, 3660, 4724, 1829, 9381, 13546, 8592, 8978, 11296, 17573, 9154, 18568, 45841, 13496, 479, 5296, 39, 443, 45841, 13496, 316], "avg_logprob": -0.2818216605157387, "compression_ratio": 1.513089005235602, "no_speech_prob": 5.364418029785156e-07, "words": [{"start": 888.62, "end": 888.96, "word": "يوم", "probability": 0.789794921875}, {"start": 888.96, "end": 889.3, "word": " يكون", "probability": 0.898193359375}, {"start": 889.3, "end": 889.58, "word": " عندنا", "probability": 0.597412109375}, {"start": 889.58, "end": 889.68, "word": " ال", "probability": 0.81103515625}, {"start": 889.68, "end": 890.12, "word": " Hemoglobin", "probability": 0.7490234375}, {"start": 890.12, "end": 890.32, "word": " F", "probability": 0.63427734375}, {"start": 890.32, "end": 890.72, "word": " عالي", "probability": 0.85400390625}, {"start": 890.72, "end": 891.16, "word": " كتير", "probability": 0.8984375}, {"start": 891.16, "end": 891.92, "word": " مغيد", "probability": 0.3155924479166667}, {"start": 891.92, "end": 892.62, "word": " بعانيش", "probability": 0.74200439453125}, {"start": 892.62, "end": 893.96, "word": " كمان", "probability": 0.8831380208333334}, {"start": 893.96, "end": 894.44, "word": " بتشوفه", "probability": 0.904541015625}, {"start": 894.44, "end": 894.58, "word": " في", "probability": 0.8486328125}, {"start": 894.58, "end": 894.88, "word": " حالة", "probability": 0.9820963541666666}, {"start": 894.88, "end": 895.14, "word": " تانية", "probability": 0.9913736979166666}, {"start": 895.14, "end": 895.54, "word": " اسمها", "probability": 0.8938802083333334}, {"start": 895.54, "end": 895.94, "word": " Hereditary", "probability": 0.6947835286458334}, {"start": 895.94, "end": 896.46, "word": " Resistance", "probability": 0.34228515625}, {"start": 896.46, "end": 896.78, "word": " of", "probability": 0.9326171875}, {"start": 896.78, "end": 897.12, "word": " Fetal", "probability": 0.633544921875}, {"start": 897.12, "end": 897.72, "word": " Hemoglobin", "probability": 0.9519856770833334}, {"start": 897.72, "end": 898.5, "word": " ما", "probability": 0.275146484375}, {"start": 898.5, "end": 898.96, "word": " بيصير", "probability": 0.8907470703125}, {"start": 898.96, "end": 899.32, "word": " في", "probability": 0.94287109375}, {"start": 899.32, "end": 899.62, "word": " هذه", "probability": 0.6298828125}, {"start": 899.62, "end": 900.02, "word": " الحالة", "probability": 0.9072265625}, {"start": 900.02, "end": 900.44, "word": " بيصيرش", "probability": 0.716845703125}, {"start": 900.44, "end": 900.76, "word": " فيها", "probability": 0.929443359375}, {"start": 900.76, "end": 901.46, "word": " shifting", "probability": 0.6337890625}, {"start": 901.46, "end": 902.04, "word": " من", "probability": 0.978515625}, {"start": 902.04, "end": 903.04, "word": " Hemoglobin", "probability": 0.7860514322916666}, {"start": 903.04, "end": 903.26, "word": " F", "probability": 0.87158203125}, {"start": 903.26, "end": 904.44, "word": " لHemoglobin", "probability": 0.82080078125}, {"start": 904.44, "end": 904.7, "word": " A", "probability": 0.9755859375}], "temperature": 1.0}, {"id": 37, "seek": 93326, "start": 905.56, "end": 933.26, "text": "و طبعا في كل الحلقات كل الحلقات بكون ال hemoglobin A2 عالى أما sickle cell trait prefer blood smear usually normal مع ده شوية target cell و solubility و ال screening test is positive و ال electrophoresis بيكون احنا فيه انا اتنين هالجيه ده hemoglobin A60% hemoglobin A40%", "tokens": [2407, 23032, 3555, 3615, 995, 8978, 28242, 21542, 1211, 4587, 9307, 28242, 21542, 1211, 4587, 9307, 4724, 30544, 2423, 8636, 45841, 13496, 316, 17, 6225, 6027, 7578, 5551, 15042, 4998, 306, 2815, 22538, 4382, 3390, 899, 14881, 2673, 2710, 20449, 11778, 3224, 13412, 2407, 10632, 3779, 2815, 4032, 1404, 836, 1140, 4032, 2423, 17732, 1500, 307, 3353, 4032, 2423, 16717, 950, 2706, 271, 4724, 1829, 30544, 1975, 5016, 8315, 8978, 3224, 1975, 8315, 1975, 2655, 1863, 9957, 8032, 6027, 7435, 1829, 3224, 11778, 3224, 8636, 45841, 13496, 316, 4550, 4, 8636, 45841, 13496, 316, 5254, 4], "avg_logprob": -0.28157217478014757, "compression_ratio": 1.4936170212765958, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 905.56, "end": 905.84, "word": "و", "probability": 0.65625}, {"start": 905.84, "end": 906.36, "word": " طبعا", "probability": 0.8275146484375}, {"start": 906.36, "end": 906.9, "word": " في", "probability": 0.7529296875}, {"start": 906.9, "end": 907.16, "word": " كل", "probability": 0.9501953125}, {"start": 907.16, "end": 907.76, "word": " الحلقات", "probability": 0.786865234375}, {"start": 907.76, "end": 907.98, "word": " كل", "probability": 0.07965087890625}, {"start": 907.98, "end": 908.52, "word": " الحلقات", "probability": 0.9755859375}, {"start": 908.52, "end": 908.84, "word": " بكون", "probability": 0.5791015625}, {"start": 908.84, "end": 908.94, "word": " ال", "probability": 0.76708984375}, {"start": 908.94, "end": 909.36, "word": " hemoglobin", "probability": 0.8070475260416666}, {"start": 909.36, "end": 909.7, "word": " A2", "probability": 0.7132568359375}, {"start": 909.7, "end": 910.24, "word": " عالى", "probability": 0.83251953125}, {"start": 910.24, "end": 911.38, "word": " أما", "probability": 0.763916015625}, {"start": 911.38, "end": 911.74, "word": " sickle", "probability": 0.52740478515625}, {"start": 911.74, "end": 911.92, "word": " cell", "probability": 0.841796875}, {"start": 911.92, "end": 912.46, "word": " trait", "probability": 0.9501953125}, {"start": 912.46, "end": 913.58, "word": " prefer", "probability": 0.54150390625}, {"start": 913.58, "end": 913.92, "word": " blood", "probability": 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"end": 921.42, "word": " screening", "probability": 0.43505859375}, {"start": 921.42, "end": 921.92, "word": " test", "probability": 0.92333984375}, {"start": 921.92, "end": 922.86, "word": " is", "probability": 0.53759765625}, {"start": 922.86, "end": 923.82, "word": " positive", "probability": 0.884765625}, {"start": 923.82, "end": 925.84, "word": " و", "probability": 0.8896484375}, {"start": 925.84, "end": 926.96, "word": " ال", "probability": 0.95166015625}, {"start": 926.96, "end": 928.18, "word": " electrophoresis", "probability": 0.80242919921875}, {"start": 928.18, "end": 928.68, "word": " بيكون", "probability": 0.8492838541666666}, {"start": 928.68, "end": 928.96, "word": " احنا", "probability": 0.9269205729166666}, {"start": 928.96, "end": 929.12, "word": " فيه", "probability": 0.6868896484375}, {"start": 929.12, "end": 929.24, "word": " انا", "probability": 0.5631103515625}, {"start": 929.24, "end": 929.64, "word": " اتنين", "probability": 0.942626953125}, {"start": 929.64, "end": 930.1, "word": " هالجيه", "probability": 0.67373046875}, {"start": 930.1, "end": 930.18, "word": " ده", "probability": 0.897705078125}, {"start": 930.18, "end": 930.64, "word": " hemoglobin", "probability": 0.8323567708333334}, {"start": 930.64, "end": 931.12, "word": " A60", "probability": 0.80810546875}, {"start": 931.12, "end": 931.64, "word": "%", "probability": 0.80810546875}, {"start": 931.64, "end": 932.18, "word": " hemoglobin", "probability": 0.8824869791666666}, {"start": 932.18, "end": 932.6, "word": " A40", "probability": 0.732421875}, {"start": 932.6, "end": 933.26, "word": "%", "probability": 0.99267578125}], "temperature": 1.0}, {"id": 38, "seek": 95152, "start": 933.74, "end": 951.52, "text": "و ال hemoglobin A2 is elevated سكل لو عملنا blood film بنشوفهاش ما لم يكن في crisis treatment بتعتمد على حاجتين في الحاجة الأولانية انك تتوعي المريض", "tokens": [2407, 2423, 8636, 45841, 13496, 316, 17, 307, 23457, 8608, 28820, 45164, 6225, 42213, 8315, 3390, 2007, 44945, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Ha5q0Kdyiac_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Ha5q0Kdyiac_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..4affd66b595f0edfa1a19f5bfd110b2cb359899d
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Ha5q0Kdyiac_raw.json
@@ -0,0 +1 @@
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spirocytosis في زيادة في الـ osmotic fragility هذا فحص ان شاء الله هتشتغلوا بداخل العمل osmotic fragility ايش ال osmotic fragility ببساطة هي قدرة الخلية على تحمل الأوساط الخارجية كيف يعني؟ يعني الخلية لها cell membrane يمنع دخول", "tokens": [6027, 8592, 1829, 38207, 2423, 2407, 5016, 25708, 8978, 2423, 39184, 416, 1766, 1686, 415, 3280, 356, 40907, 364, 14058, 365, 7006, 4314, 295, 637, 5182, 1344, 83, 8211, 8978, 30767, 1829, 18513, 3660, 8978, 2423, 39184, 3003, 76, 9411, 9241, 1140, 23758, 6156, 5016, 9381, 16472, 13412, 16606, 21984, 8032, 2655, 8592, 2655, 17082, 1211, 14407, 47525, 47283, 1211, 18863, 42213, 3003, 76, 9411, 9241, 1140, 1975, 1829, 8592, 2423, 3003, 76, 9411, 9241, 1140, 4724, 3555, 3794, 41193, 3660, 39896, 12174, 3215, 25720, 33962, 1211, 10632, 15844, 6055, 35571, 1211, 16247, 41779, 41193, 33962, 9640, 7435, 10632, 9122, 33911, 37495, 22653, 22807, 37495, 22653, 33962, 1211, 10632, 5296, 11296, 2815, 19651, 7251, 27842, 3615, 11778, 9778, 12610], 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"end": 1680.05, "text": "المعنى هو أن الـOxidized Glutathione ستبقى مكسورًا وليس مكسورًا", "tokens": [45340, 3615, 1863, 7578, 31439, 14739, 2423, 39184, 46, 87, 327, 1602, 5209, 325, 998, 5328, 8608, 2655, 3555, 4587, 7578, 3714, 4117, 3794, 13063, 14111, 995, 4032, 20292, 3794, 3714, 4117, 3794, 13063, 14111, 995], "avg_logprob": -0.7457770528020086, "compression_ratio": 1.064516129032258, "no_speech_prob": 1.3709068298339844e-06, "words": [{"start": 1670.35, "end": 1670.69, "word": "المعنى", "probability": 0.5530319213867188}, {"start": 1670.69, "end": 1670.79, "word": " هو", "probability": 0.479736328125}, {"start": 1670.79, "end": 1670.89, "word": " أن", "probability": 0.25537109375}, {"start": 1670.89, "end": 1671.41, "word": " الـOxidized", "probability": 0.5693562825520834}, {"start": 1671.41, "end": 1672.29, "word": " Glutathione", "probability": 0.8204345703125}, {"start": 1672.29, "end": 1673.99, "word": " ستبقى", "probability": 0.83486328125}, {"start": 1673.99, "end": 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{"start": 2108.25, "end": 2108.87, "word": " level", "probability": 0.92822265625}, {"start": 2108.87, "end": 2110.05, "word": " ال", "probability": 0.8349609375}, {"start": 2110.05, "end": 2110.75, "word": " haptoglobin", "probability": 0.694854736328125}, {"start": 2110.75, "end": 2111.27, "word": " بيكون", "probability": 0.9444986979166666}, {"start": 2111.27, "end": 2111.55, "word": " very", "probability": 0.86572265625}, {"start": 2111.55, "end": 2111.95, "word": " low", "probability": 0.9775390625}, {"start": 2111.95, "end": 2113.53, "word": " هى", "probability": 0.45013427734375}, {"start": 2113.53, "end": 2113.93, "word": " مغلوب", "probability": 0.7257080078125}, {"start": 2113.93, "end": 2114.17, "word": " انه", "probability": 0.649658203125}, {"start": 2114.17, "end": 2114.63, "word": " يوريا", "probability": 0.76220703125}, {"start": 2114.63, "end": 2117.41, "word": " وال", "probability": 0.65625}, {"start": 2117.41, "end": 2118.53, "word": " reticulocyte", "probability": 0.811328125}, {"start": 2118.53, "end": 2119.71, "word": " عالية", "probability": 0.97607421875}, {"start": 2119.71, "end": 2120.83, "word": " ال", "probability": 0.94970703125}, {"start": 2120.83, "end": 2121.47, "word": " RBCs", "probability": 0.693603515625}, {"start": 2121.47, "end": 2121.93, "word": " count", "probability": 0.94970703125}], "temperature": 1.0}, {"id": 83, "seek": 214021, "start": 2123.51, "end": 2140.21, "text": "هيموجلوبينو يوريا هذا ال body بنشوفها في ال peripheral blood إذا سبقناها ب متريني blue و الفحص الأخير اللي هو met hemoglobin reduction test و أنا اتوقف هنا مشاء الله", "tokens": [3224, 32640, 29245, 1211, 37746, 9957, 2407, 7251, 13063, 25528, 23758, 2423, 1772, 44945, 8592, 38688, 11296, 8978, 2423, 40235, 3390, 11933, 15730, 8608, 3555, 4587, 8315, 11296, 4724, 44650, 2288, 9957, 1829, 3344, 4032, 27188, 5016, 9381, 16247, 9778, 13546, 13672, 1829, 31439, 1131, 8636, 45841, 13496, 11004, 1500, 4032, 41850, 1975, 2655, 30543, 5172, 34105, 37893, 16606, 21984], "avg_logprob": -0.4147028727609603, "compression_ratio": 1.4078212290502794, "no_speech_prob": 1.4901161193847656e-06, "words": [{"start": 2123.51, "end": 2124.21, "word": "هيموجلوبينو", "probability": 0.48525565011160715}, {"start": 2124.21, "end": 2124.65, "word": " يوريا", "probability": 0.7848307291666666}, {"start": 2124.65, "end": 2125.57, "word": " هذا", "probability": 0.0631103515625}, {"start": 2125.57, "end": 2125.69, "word": " ال", "probability": 0.83203125}, {"start": 2125.69, "end": 2125.83, "word": " body", "probability": 0.57958984375}, {"start": 2125.83, "end": 2126.47, "word": " بنشوفها", "probability": 0.84149169921875}, {"start": 2126.47, "end": 2126.77, "word": " في", "probability": 0.79541015625}, {"start": 2126.77, "end": 2127.61, "word": " ال", "probability": 0.94091796875}, {"start": 2127.61, "end": 2128.27, "word": " peripheral", "probability": 0.78173828125}, {"start": 2128.27, "end": 2128.85, "word": " blood", "probability": 0.9873046875}, {"start": 2128.85, "end": 2129.35, "word": " إذا", "probability": 0.7509765625}, {"start": 2129.35, "end": 2129.91, "word": " سبقناها", "probability": 0.86689453125}, {"start": 2129.91, "end": 2130.01, "word": " ب", "probability": 0.61474609375}, {"start": 2130.01, "end": 2130.49, "word": " متريني", "probability": 0.65679931640625}, {"start": 2130.49, "end": 2130.77, "word": " blue", "probability": 0.70947265625}, {"start": 2130.77, "end": 2132.01, "word": " و", "probability": 0.53466796875}, {"start": 2132.01, "end": 2133.11, "word": " الفحص", "probability": 0.8347981770833334}, {"start": 2133.11, "end": 2133.55, "word": " الأخير", "probability": 0.9041341145833334}, {"start": 2133.55, "end": 2133.71, "word": " اللي", "probability": 0.6876220703125}, {"start": 2133.71, "end": 2133.87, "word": " هو", "probability": 0.91748046875}, {"start": 2133.87, "end": 2134.19, "word": " met", "probability": 0.281005859375}, {"start": 2134.19, "end": 2135.05, "word": " hemoglobin", "probability": 0.8732096354166666}, {"start": 2135.05, "end": 2136.15, "word": " reduction", "probability": 0.86328125}, {"start": 2136.15, "end": 2136.79, "word": " test", "probability": 0.95947265625}, {"start": 2136.79, "end": 2138.31, "word": " و", "probability": 0.72509765625}, {"start": 2138.31, "end": 2138.43, "word": " أنا", "probability": 0.72216796875}, {"start": 2138.43, "end": 2138.95, "word": " اتوقف", "probability": 0.8240966796875}, {"start": 2138.95, "end": 2139.23, "word": " هنا", "probability": 0.9794921875}, {"start": 2139.23, "end": 2139.95, "word": " مشاء", "probability": 0.673828125}, {"start": 2139.95, "end": 2140.21, "word": " الله", "probability": 0.92578125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2140.92625, "duration_after_vad": 2064.8974999999923}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KE_VwFuQz28_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KE_VwFuQz28_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..bb209556bbb97a20b1856be90439c8d66fc3e40f
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KE_VwFuQz28_raw.srt
@@ -0,0 +1,288 @@
+1
+00:00:02,870 --> 00:00:07,570
+بسم الله الرحمن الرحيم والحمد لله رب العالمين
+
+2
+00:00:07,570 --> 00:00:12,030
+والصلاة والسلام على سيد الخلق أجمعين سيدنا محمد
+
+3
+00:00:12,030 --> 00:00:18,130
+الصادق الأمين بداية أرحبكم جميعا في بداية هذا
+
+4
+00:00:18,130 --> 00:00:25,310
+الفصل الذي ندعو الله أن يكون فصله سعادة وراحة لنا
+
+5
+00:00:25,310 --> 00:00:30,730
+ولكم وأن يزيح ربنا هذه الغمعنة بإذن الله
+
+6
+00:00:36,780 --> 00:00:40,520
+مساقنة ان شاء الله سيكون علم دم سريري
+
+7
+00:00:43,080 --> 00:00:49,080
+و .. و هو مساق كباقي المساقات و اتباعا لتعليم
+
+8
+00:00:49,080 --> 00:00:56,240
+الجامعة سيكون بيتكون من فصلين او نصفين نصف الاول
+
+9
+00:00:56,240 --> 00:01:04,200
+او النصفي و عليه اربعين درجة سناخذ بهي quizين
+
+10
+00:01:04,200 --> 00:01:15,980
+وامتحان نصفي و هذا يكون على ال modelبينما النهائي
+
+11
+00:01:15,980 --> 00:01:20,800
+ان شاء الله سيكون في الجامعة وعليه ستين درجة
+
+12
+00:01:20,800 --> 00:01:31,210
+مساقنا بيشرح نقطتين مهمات بيحكي عليهامكونات الدم
+
+13
+00:01:31,210 --> 00:01:36,630
+الأساسية وهي الخلايا الأساسية blood elements وهي
+
+14
+00:01:36,630 --> 00:01:42,350
+ال RBCs و ال white BCs بشكل أساسي وسيكون لنا لقاء
+
+15
+00:01:42,350 --> 00:01:49,890
+آخر لنحكي في فصل آخر عن الصفائح الدموية أما فيما
+
+16
+00:01:49,890 --> 00:01:57,630
+يتعلق بال white BCs و ال RBCs فسنحكي على ال RBCs
+
+17
+00:01:57,630 --> 00:02:02,640
+functionand disorders طبعا ال disorders اللي
+
+18
+00:02:02,640 --> 00:02:08,600
+بتتعلق بال RBCs هتكون بتتعلق بأنواع الأنيميا
+
+19
+00:02:08,600 --> 00:02:14,340
+المختلفة بينما ال white pcs بتتعلق بكل الأمراض
+
+20
+00:02:14,340 --> 00:02:17,320
+السرطانية او ماليجنانسي
+
+21
+00:02:19,420 --> 00:02:24,320
+الـ white pieces فبالتالي الفصل أو البصاق سيكون
+
+22
+00:02:24,320 --> 00:02:33,640
+يتكوّن من شقين شق الأول سنتكلم فيه على ال RPCs and
+
+23
+00:02:33,640 --> 00:02:37,760
+disorders function and disorders والجزء التاني
+
+24
+00:02:37,760 --> 00:02:42,700
+سنتكلم فيه على ال white pieces and its disorders
+
+25
+00:02:42,700 --> 00:02:45,880
+ونبدأ
+
+26
+00:02:45,880 --> 00:02:46,820
+على بركة الله
+
+27
+00:02:49,650 --> 00:02:57,410
+طبعا بداية سنتكلم في هذه المحاضرة على ال normal
+
+28
+00:02:57,410 --> 00:03:00,570
+hematopoiesis
+
+29
+00:03:00,570 --> 00:03:12,050
+و هو مصنع الدم الأساسي و هو مصنع الدم الأساسي طبعا
+
+30
+00:03:12,050 --> 00:03:14,670
+قبل أن نبدأ في هذه
+
+31
+00:03:16,860 --> 00:03:22,780
+هذه المحاضرة تعلمون أن كل شيء له بداية و نهاية
+
+32
+00:03:22,780 --> 00:03:29,860
+وبالتالي له عمر زمني محدد ينتهي بانتهاء هذا العمر
+
+33
+00:03:29,860 --> 00:03:34,360
+الزمني حتى خلايا الجسم تنتهي بانتهاء عمرها الزمني
+
+34
+00:03:34,360 --> 00:03:41,420
+وبالتالي لو أن هذه الخلايا لا تتجدد لانتهينا
+
+35
+00:03:41,420 --> 00:03:47,190
+بانتهاء عمر الخلايا الزمنيةولكن منها الخالق علينا
+
+36
+00:03:47,190 --> 00:03:54,090
+أن هذه الخلايا تتجدد وتتصنع في الجسم بشكل دائم في
+
+37
+00:03:54,090 --> 00:04:01,090
+مصنع سنتعرف عليه وعلى وظائفه واماكنه المختلفة ان
+
+38
+00:04:01,090 --> 00:04:06,550
+شاء الله وامثلة على الأعمار الزمنية للخلايا على
+
+39
+00:04:06,550 --> 00:04:14,590
+سبيل المثال RBC عمرها الزمن 800 ل120 يوممعامل
+
+40
+00:04:14,590 --> 00:04:19,630
+إنتاجها ومعدل إنتاجها 2 في 10 القوة 11 في اليوم
+
+41
+00:04:19,630 --> 00:04:27,210
+بينما في ال second 2 أو 3 من 10 مليون خلية في كل
+
+42
+00:04:27,210 --> 00:04:35,990
+ثانية يتصنع طبعا هذا بيعطينا عوارف 7 كيلو أو 3 من
+
+43
+00:04:35,990 --> 00:04:43,590
+10 من ال RBC في السنةيعني لو هذه الخلايا لا تموت
+
+44
+00:04:43,590 --> 00:04:55,210
+سنزيد 7.3 كيلو وزناً سنويًا فقط من إنتاج ال RBCs
+
+45
+00:04:55,210 --> 00:05:01,710
+لكن زي ما قلنا أن هذه لعمر زمن محدد تموت وتتجدد
+
+46
+00:05:05,620 --> 00:05:10,220
+مجدد لهذه الخلايا باقي الخلايا نيتروفيل على سبيل
+
+47
+00:05:10,220 --> 00:05:16,480
+المثال أمرها زماني 6 ساعات ومعدل إنتاجها 3×10¹10
+
+48
+00:05:16,480 --> 00:05:23,440
+بما يعادل 350 ألف خلية في الثانية وهذه بزيادة
+
+49
+00:05:23,440 --> 00:05:29,900
+وزنية 10 أو 9 من 10 كيلو جرام في السنة الواحدة
+
+50
+00:05:29,900 --> 00:05:38,730
+platelet كذلكlife span سبعة أيام ومعامل إنتاجها
+
+51
+00:05:38,730 --> 00:05:44,090
+واحد في عشر وواحد عشر او ما يعادل واحد واتنين من
+
+52
+00:05:44,090 --> 00:05:52,470
+عشرة مليون صفيحة لكل ثانية و بزيادة وزنية اربعة
+
+53
+00:05:52,470 --> 00:05:56,930
+وستة من عشرة kilogram lymphocyte ال half-life
+
+54
+00:05:56,930 --> 00:06:00,630
+تبعتها عشر أيام plus و minus طبعا تختلف باختلاف
+
+55
+00:06:00,630 --> 00:06:07,420
+نوع الخليةمعامل او معدل انتاجها 1 في 10 هو 10 خلية
+
+56
+00:06:07,420 --> 00:06:14,860
+في اليوم بمعدل 116000 خلية في ثانية و بزيادة وزنية
+
+57
+00:06:14,860 --> 00:06:22,440
+3.7 كيلو لو جمعنا معدل زيادة وزن الإنسان فقط من
+
+58
+00:06:22,440 --> 00:06:27,980
+خلايا من انتاج الخلايا هذه 26.5 كيلو جرام سنوي
+
+59
+00:06:27,980 --> 00:06:33,320
+تخيلوا لو هذه الخلايا لا تموتيعني في عشر سنوات
+
+60
+00:06:33,320 --> 00:06:40,460
+بصير وزن الإنسان زايد مائتين وخمسة وستين كيلو فقط
+
+61
+00:06:40,460 --> 00:06:50,440
+من إنتاج هذه الخلايا ال هو
+
+62
+00:06:50,440 --> 00:06:56,260
+بالتالي لابد من وجود ايش من وجود نظام
+
+63
+00:06:58,730 --> 00:07:03,050
+يتم من خلال أموت الخلايا وتجددها باستمرار بما يضمن
+
+64
+00:07:03,050 --> 00:07:11,430
+التوازن الطبيعي للجسم من هذا المنطلق طلعنا بهذه
+
+65
+00:07:11,430 --> 00:07:14,450
+الجملة
+
+66
+00:07:14,450 --> 00:07:20,110
+ان our body is in a continuous dynamic and a very
+
+67
+00:07:20,110 --> 00:07:23,780
+rapid turnover to be able to liveيعني في
+
+68
+00:07:23,780 --> 00:07:30,400
+continuous dynamic في حركة دائمة و very rapid cell
+
+69
+00:07:30,400 --> 00:07:37,320
+turnover وموت سريع للخلايا و تجددها عشان تم الحياة
+
+70
+00:07:37,320 --> 00:07:42,820
+بشكل طبيعي كم بتتم هذه العملية بتتم من خلال خلية
+
+71
+00:07:42,820 --> 00:07:47,600
+أساسية سموها stem cell
+
+72
+00:07:50,410 --> 00:07:53,130
+يسموها stem cell
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY.srt
new file mode 100644
index 0000000000000000000000000000000000000000..dfe740d1fa779f74393153794508c0951a9732af
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY.srt
@@ -0,0 +1,3539 @@
+1
+00:00:03,190 --> 00:00:09,150
+باسم الله الرحمن الرحيم سابق وحكينا أن ال
+
+2
+00:00:09,150 --> 00:00:13,510
+hemopoiesis هي عملية development and production of
+
+3
+00:00:13,510 --> 00:00:19,450
+cells بتتم فيها تطور 
+
+4
+00:00:19,450 --> 00:00:24,710
+وندوش هذه الخلايا وقولنا عشان تتم هذه العملية
+
+5
+00:00:24,710 --> 00:00:29,810
+نحتاج إلى ثلاثة عوامل أساسية العامل الأولاني هو وجود
+
+6
+00:00:29,810 --> 00:00:35,910
+الـ stem cell و العامل الثاني هو الـ hemopoietic
+
+7
+00:00:35,910 --> 00:00:38,910
+micro environment و العامل الثالث الـ growth factor
+
+8
+00:00:38,910 --> 00:00:44,110
+وهذه عملية عملية بناء بتشبه أي عملية بناء يعني أنا
+
+9
+00:00:44,110 --> 00:00:49,430
+دايماً بشبهها ببناء مسجد أو بناء منزل عشان تبني
+
+10
+00:00:49,430 --> 00:00:54,770
+المنزل بدك ثلاث شغلات بدك الأرض اللي بدك تبني عليها
+
+11
+00:00:54,770 --> 00:01:01,350
+ثم مواد البناء ثم العمال اللي بدهم يبنوا البناء
+
+12
+00:01:02,150 --> 00:01:05,370
+طبعاً الأرض اللي بدنا نبني عليها متمثلة هنا بالـ
+
+13
+00:01:05,370 --> 00:01:11,550
+hemopoietic micro environment ثم مواد البناء
+
+14
+00:01:11,550 --> 00:01:15,710
+متمثلة بالـ stem cell ثم العمال اللي هم الـ
+
+15
+00:01:15,710 --> 00:01:20,770
+hemopoietic growth factor وحكينا عن الـ stem cell
+
+16
+00:01:20,770 --> 00:01:26,730
+في الفيديو السابق بنوع من التفصيل ووصلنا إلى الـ
+
+17
+00:01:26,730 --> 00:01:31,290
+hemopoietic micro environment الـ stem cell
+
+18
+00:01:58,600 --> 00:02:04,030
+الاستمثال الاستمثال اللي وصل على سيدنا محمد حكينا
+
+19
+00:02:04,030 --> 00:02:06,390
+عليها بالتفصيل ووصلنا للـ hemipotic 
+
+20
+00:02:06,390 --> 00:02:11,490
+microenvironment وجونا لاستمثل لا تنمو ولا تنضج
+
+21
+00:02:11,490 --> 00:02:15,310
+إلا في special microenvironment ماذا يميز هذه الـ
+
+22
+00:02:15,310 --> 00:02:23,830
+environment الذي يميزها الآتي؟ لمرة واحدة إنه هي 
+
+23
+00:02:23,830 --> 00:02:31,530
+عبارة عن طبقة من الخلايا اسمها stromal matrix area
+
+24
+00:02:32,570 --> 00:02:37,930
+بهذه الخلايا بتفرز
+
+25
+00:02:37,930 --> 00:02:42,830
+الـ growth factors و بتزود الخلايا الغير ناضجة اللي
+
+26
+00:02:42,830 --> 00:02:47,370
+بدها تَنضج بـ growth factor و بـ nutrient عشان تتطور
+
+27
+00:02:47,370 --> 00:02:54,470
+نمراً اثنين أن الخلايا الغير ناضجة على سطحها الـ
+
+28
+00:02:54,470 --> 00:02:59,550
+receptors و الـ stromal cell هذه الـ stromal matrix
+
+29
+00:02:59,550 --> 00:03:03,430
+أو area أو الـ stromal cell اللي اللي بتبطن جدار
+
+30
+00:03:03,430 --> 00:03:08,170
+الـ bone marrow أيضاً عليها receptors ما يربط
+
+31
+00:03:08,170 --> 00:03:15,670
+الخلايا الغير ناضجة بالـ stromal cell هو certain
+
+32
+00:03:15,670 --> 00:03:21,650
+receptors و الواصلة هي عبارة عن protein، glycine،
+
+33
+00:03:21,650 --> 00:03:25,960
+molecule أو طبعاً موجودة على الـ stromal cells زي الـ
+
+34
+00:03:25,960 --> 00:03:29,660
+macrofage و الـ fibroblast و الـ fat cells و أنا
+
+35
+00:03:29,660 --> 00:03:34,660
+هأشوف الصورة بوضوح أيضاً ما يميزها أن there is
+
+36
+00:03:34,660 --> 00:03:38,820
+niches lineage specific region بيسموها niches
+
+37
+00:03:38,820 --> 00:03:46,500
+أحشاش موجودة في أماكن اللي هو الـ الـ الـ bone marrow
+
+38
+00:03:46,500 --> 00:03:53,350
+أو أماكن تصنيع الخلايا و بيسموا هذه المناطق هي 
+
+39
+00:03:53,350 --> 00:03:58,050
+عشاش موجودة فيها أو تتمركز فيها اللي هو الـ stem
+
+40
+00:03:58,050 --> 00:04:03,390
+cell و غالباً الـ stem cell بتضل تمشي تمشي تمشي من
+
+41
+00:04:03,390 --> 00:04:06,830
+الـ blood stream لغاية ما تصل للعش تبعها و هناك
+
+42
+00:04:06,830 --> 00:04:18,530
+بيبدأ عملية ندولها الـ nices فيها micro environment
+
+43
+00:04:18,530 --> 00:04:25,700
+بتلعب دور كبير and differentiation of proliferative
+
+44
+00:04:25,700 --> 00:04:32,860
+cell ثم أيضاً بتفرز عوامل تعمل inhibition للـ
+
+45
+00:04:32,860 --> 00:04:40,240
+-apoptosis طبعاً هذا بيشبهوا بخصائص malignant cell
+
+46
+00:04:40,240 --> 00:04:44,180
+اللي هي في myeloid leukemia اللي أصلاً ما
+
+47
+00:04:47,970 --> 00:04:53,950
+أيضاً بيصير فيها prevention لمن؟ للـ -apoptosis آخر
+
+48
+00:04:53,950 --> 00:04:57,390
+حاجة موجودة في الـ micro environment هي الـ
+
+49
+00:04:57,390 --> 00:05:03,550
+-cynosoids فتحات في أعلى الـ bone marrow وهذه
+
+50
+00:05:03,550 --> 00:05:09,790
+الفتحات مبطنة بـ epithelial cells معينة بتلعب دور
+
+51
+00:05:09,790 --> 00:05:16,550
+كبير في عملية إنتاج في عملية إنتاج and regulate
+
+52
+00:05:16,550 --> 00:05:17,490
+growth factors
+
+53
+00:05:24,490 --> 00:05:34,110
+وهذه الصورة بتودّي لنا الـ stromal cell و الـ
+
+54
+00:05:34,110 --> 00:05:39,290
+hemobiotic cells و كيفية ارتباط كل من هما والآخر
+
+55
+00:05:39,290 --> 00:05:43,410
+هي الـ stem cell بتمثل كل progenitor or immature
+
+56
+00:05:43,410 --> 00:05:47,810
+cell وهي الـ stromal cell stromal cell هي عبارة عن
+
+57
+00:05:47,810 --> 00:05:52,090
+fat cell, fibroblast, macrophage, T cell وهكذا
+
+58
+00:05:52,090 --> 00:05:58,330
+كلها قاعدة على endothelial cells ماشي ثم في ترابط
+
+59
+00:05:58,330 --> 00:06:01,990
+ما بين الـ immature cell و هذه الخلايا قولنا هذه
+
+60
+00:06:01,990 --> 00:06:06,310
+الخلايا بتزود الـ immature cell بالأكل و بالـ growth
+
+61
+00:06:06,310 --> 00:06:10,990
+factor nutrient and growth factors و أيضاً الخلايا
+
+62
+00:06:10,990 --> 00:06:16,210
+طول ما هي immature بتضل مرتبطة بهذه الخلايا و كل ما
+
+63
+00:06:16,210 --> 00:06:21,530
+صار فيه نضوج لها بتبدأ تتحلل من هذه الخلايا و تن و
+
+64
+00:06:21,530 --> 00:06:25,270
+ترتقي إلى الأعلى لغاية ما تصل إلى فتحات الـ bone
+
+65
+00:06:25,270 --> 00:06:30,810
+marrow في الأعلى و هناك بيبدأ عملية اللي هو خروجها
+
+66
+00:06:30,810 --> 00:06:35,710
+إلى الـ peripheral blood اتفقنا
+
+67
+00:06:35,710 --> 00:06:39,390
+على أن الـ stromathelm تتكون من أنواع للـ cell fat
+
+68
+00:06:39,390 --> 00:06:46,330
+cell fibroblast Lymphocytes and macrophages وهذه هي 
+
+69
+00:06:46,330 --> 00:06:51,010
+الـ hemopoietic macro environment العامل الأخير في 
+
+70
+00:06:51,010 --> 00:06:53,490
+الـ hemopoiesis هو الـ hemopoietic growth factors
+
+71
+00:06:53,490 --> 00:06:57,110
+and these are glycoprotein substance or hormones
+
+72
+00:06:57,110 --> 00:07:00,630
+لأنه they act as hormone that regulate
+
+73
+00:07:00,630 --> 00:07:04,050
+proliferation and differentiation of hemopoietic
+
+74
+00:07:04,050 --> 00:07:08,290
+progenitor cell and even can regulate the function
+
+75
+00:07:08,290 --> 00:07:12,030
+of mature cells من أين بيطلعوا؟ بيطلعوا من الـT
+
+76
+00:07:12,030 --> 00:07:15,570
+lymphocytes, monocytes, macrophages, stromal cell
+
+77
+00:07:15,570 --> 00:07:22,030
+and the major growth factors .. major social
+
+78
+00:07:22,030 --> 00:07:25,830
+growth factors are these cells بعد that two
+
+79
+00:07:25,830 --> 00:07:29,330
+hormone or two growth factors الإريثروبورتين بيطلع
+
+80
+00:07:29,330 --> 00:07:34,130
+غالباً من الـ kidney و الـ thrombopoietin تبع الـ
+
+81
+00:07:34,130 --> 00:07:40,720
+platelet بيطلع من الـ liver و هذه هي صفاتهم they
+
+82
+00:07:40,720 --> 00:07:45,060
+regulate growth and differentiation شو صفاتهم الـ
+
+83
+00:07:45,060 --> 00:07:49,220
+glycoprotein with clinical utility صفات مميزة and
+
+84
+00:07:49,220 --> 00:07:52,300
+with clinical specificity or different specificity
+
+85
+00:07:52,300 --> 00:07:55,720
+كل واحد وظيفته and with different origin شفنا
+
+86
+00:07:55,720 --> 00:07:59,260
+أنه بيطلع من أكثر من مكان and usually bind to
+
+87
+00:07:59,260 --> 00:08:02,800
+cognate receptor برتبته بالـ receptor القريب منهم وين
+
+88
+00:08:02,800 --> 00:08:07,460
+على progenitor cell and they act locally or at
+
+89
+00:08:07,460 --> 00:08:10,820
+distance زي صفات الهرمون بيشتغلوا على المطرح أو
+
+90
+00:08:10,820 --> 00:08:14,600
+بيشتغلوا على الخلايا البعيدة الـ regulated
+
+91
+00:08:14,600 --> 00:08:17,620
+proliferation differentiation usually من صفاته
+
+92
+00:08:17,620 --> 00:08:22,600
+أيضاً من صفاتهم أن they prevent apoptosis و
+
+93
+00:08:22,600 --> 00:08:26,860
+enhance the function of some end stage بمعنى أن
+
+94
+00:08:26,860 --> 00:08:30,700
+they can also regulate the function of mature stem
+
+95
+00:08:30,700 --> 00:08:36,160
+of mature cell وهذا المثال على ذلك أن GMCSF
+
+96
+00:08:36,160 --> 00:08:41,720
+اختصاراً لـ granulocyte, monocyte Colony Stimulating
+
+97
+00:08:41,720 --> 00:08:45,560
+Factor بيلعب دور كبير في الـ Function of
+
+98
+00:08:45,560 --> 00:08:52,880
+Polymorphic Nuclear Cells أمثلة
+
+99
+00:08:52,880 --> 00:08:56,120
+على Hemopoietic Growth Factor هذا هو GMCSF سميناها
+
+100
+00:08:56,120 --> 00:09:00,320
+Granulocyte Macrophage Colony Stimulating Factor
+
+101
+00:09:01,500 --> 00:09:06,040
+And macrophage colon stimulating factor من الاسم
+
+102
+00:09:06,040 --> 00:09:09,720
+الماضي أنَّها تشتغل على خلايا الـ macrophage و هذه
+
+103
+00:09:09,720 --> 00:09:12,440
+كانت تشتغل على الـ granulocyte و الـ macrophage الـ
+
+104
+00:09:12,440 --> 00:09:15,980
+erythropoietin بيلعب دور كبير في stimulating hormone
+
+105
+00:09:15,980 --> 00:09:22,950
+RBC stimulating hormone ثم any other factor مثل آخر
+
+106
+00:09:22,950 --> 00:09:26,570
+الـ thrombopoietin بيلعب دور كبير في stimulation of
+
+107
+00:09:26,570 --> 00:09:30,870
+megakaryopoiesis الـ megakaryopoiesis هي عبارة عن
+
+108
+00:09:30,870 --> 00:09:36,310
+عملية نضوج أو بناء الـ platelet أو الـ
+
+109
+00:09:36,310 --> 00:09:42,130
+megakaryocytes اللي بيطلع لي الـ platelet أمثلة أخرى
+
+110
+00:09:42,130 --> 00:09:44,350
+لـ growth factor أيضاً زي مثلًا أنهم colony
+
+111
+00:09:44,350 --> 00:09:48,810
+stimulating factor أيضاً they can be named by
+
+112
+00:09:48,810 --> 00:09:51,870
+interleukins of certain cytokines بتلعب دور كبير
+
+113
+00:09:51,870 --> 00:09:54,950
+جداً في عملية الـ hemopoiesis و أمثلة على ذلك
+
+114
+00:09:54,950 --> 00:10:01,430
+interleukin 1,3,5,4,5,6 وهكذا وفي inhibitory
+
+115
+00:10:01,430 --> 00:10:03,890
+growth factor زي الـ transforming growth factor
+
+116
+00:10:03,890 --> 00:10:08,070
+beta برضه يعني بيلعب في شيء بيلعب stimulating وفي
+
+117
+00:10:08,070 --> 00:10:11,730
+شيء بيلعب inhibition و هي فيه stem cell factor بيلعب
+
+118
+00:10:11,730 --> 00:10:20,170
+دور كبير على الـ very immature stem cell دورهم
+
+119
+00:10:20,170 --> 00:10:25,410
+واضح جداً هذه عبارة عن الـ hemopoietic tree اللي
+
+120
+00:10:25,410 --> 00:10:30,550
+قلنا pluripotent stem cell تدينا colony forming
+
+121
+00:10:30,550 --> 00:10:38,670
+unit GEMM اللي هو granulocyte erythroid macrophage
+
+122
+00:10:44,560 --> 00:10:49,590
+megakaryocytes و monocytes megakaryocytes أو
+
+123
+00:10:49,590 --> 00:10:52,230
+megakaryocytes أو megakaryocytes أو megakaryo
+
+124
+00:10:52,230 --> 00:10:57,150
+cytes أو
+
+125
+00:10:57,150 --> 00:11:05,650
+megakaryocytes أو megakaryocytes أو megakaryo
+
+126
+00:11:05,650 --> 00:11:08,410
+cytes أو megakaryocytes أو megakaryocytes أو
+
+127
+00:11:08,410 --> 00:11:13,190
+megakaryocytes أو megakaryocytes أو megakaryo
+
+128
+00:11:13,190 --> 00:11:14,810
+cytes أو megakaryocytes أو megakaryocytes أو
+
+129
+00:11:14,810 --> 00:11:17,850
+megakaryocytes أو megakaryocytes أو certain
+
+130
+00:11:17,850 --> 00:11:23,330
+growth factor وإن كل خطوة من هذه الخطوات تحتاج إلى
+
+131
+00:11:23,330 --> 00:11:28,210
+هذا الـ growth factor لكي تتم وإن غياب هذا الـ
+
+132
+00:11:28,210 --> 00:11:32,850
+growth factor لا ينقل الخلية من مرحلة إلى مرحلة
+
+133
+00:11:32,850 --> 00:11:39,870
+أثناء نضوجها و بالعكس تقف الخلية عند مرحلة معينة
+
+134
+00:11:39,870 --> 00:11:45,250
+هذه أمثلة على hemipedic cytokine و الخلايا اللي
+
+135
+00:11:45,250 --> 00:11:50,190
+بتشتغل عليها طبعاً مش مطالبين بحفظ هذا الموضوع لكن
+
+136
+00:11:50,190 --> 00:11:54,410
+فيه أمور رئيسية يعني لما أقول لكوا GM CSF هتعرفوا
+
+137
+00:11:54,410 --> 00:11:57,390
+أنها بتشتغل على الـ granulocyte ما أجرّفشي لما أقول
+
+138
+00:11:57,390 --> 00:12:01,630
+لكوا GCSF مانتوا بتشتغل على الـ granulocyte وهذه
+
+139
+00:12:01,630 --> 00:12:05,610
+صورة أخرى بتبين كل خطوة من الخطوات احتاج إلى
+
+140
+00:12:05,610 --> 00:12:10,290
+growth factor معين عشان ينقلها أو interleukin عشان 
+
+141
+00:12:10,290 --> 00:12:17,430
+ينقلها من مرحلة إلى مرحلة طيب ما هي الـ order of
+
+142
+00:12:17,430 --> 00:12:21,150
+blood cell formation اللي هو عملية المراحل التي
+
+143
+00:12:21,150 --> 00:12:26,790
+تمر فيها orderly يعني بالترتيب الـ stem cell أو 
+
+144
+00:12:26,790 --> 00:12:30,930
+blood cell formation؟ قلنا أول خلية هي الـ stem
+
+145
+00:12:30,930 --> 00:12:34,950
+cell وقلنا سميناها أمهات الخلايا هي الأساس لكل
+
+146
+00:12:34,950 --> 00:12:35,430
+الخلايا
+
+147
+00:12:38,090 --> 00:12:41,730
+مرحلة أخرى اسمها Progenitor Cell وقد تكون
+
+148
+00:12:41,730 --> 00:12:46,130
+Multipotential أو Bipotential أو Unipotential طبعًا
+
+149
+00:12:46,130 --> 00:12:51,970
+أعرفوا المصطلح Multi يعني متعددة أو بتديني two lines
+
+150
+00:12:51,970 --> 00:12:58,690
+أو بتديني one line والمرحلة الثالثة هي الـ
+
+151
+00:12:58,690 --> 00:13:02,570
+precursor cells ماشي؟
+
+152
+00:13:03,770 --> 00:13:09,870
+وهذه عبارة عن بيسموها recognizable cell وهي عبارة
+
+153
+00:13:09,870 --> 00:13:14,570
+عن precursor ما قبل النضوج ماشي بيسموها maturing
+
+154
+00:13:14,570 --> 00:13:20,390
+يعني in process of maturation في عملية النضوج هذه
+
+155
+00:13:20,390 --> 00:13:25,540
+عبارة عن خلايا بيسميها Recognizable cell نبدأ نعطي
+
+156
+00:13:25,540 --> 00:13:30,360
+أسماء معينة لها ثم في النهاية بتصل الخلية في
+
+157
+00:13:30,360 --> 00:13:35,180
+نضوجها إلى الـ mature form بسموها المرحلة
+
+158
+00:13:35,180 --> 00:13:42,270
+terminally differentiated cells أو maturing cells وهذا
+
+159
+00:13:42,270 --> 00:13:47,710
+مثال على ذلك أيها عبارة عن خلية Stoma Cell أي خلية 
+
+160
+00:13:47,710 --> 00:13:50,970
+Stem Cell متفاعلة مع Stoma Cell صار لها
+
+161
+00:13:50,970 --> 00:13:56,350
+differentiation ودتني Progenitor Cell لساتنا ما
+
+162
+00:13:56,350 --> 00:14:01,150
+بنقدر نعطيها اسمها فقط بنشوفها by cultural media
+
+163
+00:14:01,150 --> 00:14:06,190
+ثم بعد ذلك بتمر الخلية في الـ precursor cell وعبارة
+
+164
+00:14:06,190 --> 00:14:11,150
+عن مراحل بتمر فيها الخلية ماشي لغاية ما تصل إلى الـ
+
+165
+00:14:11,150 --> 00:14:15,070
+mature form أو recognizable form اللي بعد النضوج تصل
+
+166
+00:14:15,070 --> 00:14:19,650
+إلى الـ mature form وده الـ figure شفناها قبل كده
+
+167
+00:14:19,650 --> 00:14:24,330
+قلنا أن الخلية من صفاتها أن في البداية بيكون فيه
+
+168
+00:14:24,330 --> 00:14:31,310
+self renewal كتير بيقل كل ما زاد النضوج وكل ما
+
+169
+00:14:31,310 --> 00:14:34,190
+صارت ناضجة بيقل
+
+170
+00:14:36,470 --> 00:14:40,210
+وهنا بيصير فيه زيادة في الـ differentiation بت... و
+
+171
+00:14:40,210 --> 00:14:45,110
+شوي شوي بتقل والـ self renewal process بتشوي شوي
+
+172
+00:14:45,110 --> 00:14:50,670
+بتقل لغاية ما تصل ل الـ match والـ four وهذا العكس
+
+173
+00:14:54,470 --> 00:14:57,470
+طيب ما هي صفات الـ stem cell؟  صفات الـ stem cell هي
+
+174
+00:14:57,470 --> 00:15:00,990
+عملها عن undifferentiated cell طبيعي هي لا نتعرف 
+
+175
+00:15:00,990 --> 00:15:03,190
+عليها that give rise to all the bone marrow cell
+
+176
+00:15:03,190 --> 00:15:06,450
+قلنا هي أمهات الخلايا بتعطينا كل أنواع الخلايا
+
+177
+00:15:06,450 --> 00:15:10,010
+بتشكل فقط point five percent of all marrow cell
+
+178
+00:15:10,010 --> 00:15:15,810
+marrow nucleated cell يعني نص في المية يبقى عددها
+
+179
+00:15:15,810 --> 00:15:20,400
+قليل ولا مش قليل؟ عددها قليل it's multi-potential
+
+180
+00:15:20,400 --> 00:15:24,560
+طبعًا المتعددة الخصائص عشان هيك بيسموها
+
+181
+00:15:24,560 --> 00:15:28,600
+pluripotent stem cell and high self-renewal في
+
+182
+00:15:28,600 --> 00:15:32,680
+البداية بيكون في self-renewal عالي اللي بتدينا بعد
+
+183
+00:15:32,680 --> 00:15:37,500
+هيك daughter stem cell that are exact replicates
+
+184
+00:15:37,500 --> 00:15:43,920
+of the parent نفسها نفس الـ parent cell و it's
+
+185
+00:15:43,920 --> 00:15:46,990
+not morphologically distinguishable بمعنى إحنا ما
+
+186
+00:15:46,990 --> 00:15:55,090
+بنقدر نميزها وحوالي 95% من الـ stem cell are out
+
+187
+00:15:55,090 --> 00:15:59,250
+of cell cycle بمعنى مش شغال فقط اللي بيعمل عملية
+
+188
+00:15:59,250 --> 00:16:05,970
+التشغيل هو 5% من الـ 0.5% اللي في الـ bone marrow يعني
+
+189
+00:16:05,970 --> 00:16:15,050
+95% موجود in G node mode phase وهذا عبارة عن اللي
+
+190
+00:16:15,050 --> 00:16:21,770
+هو Quiescent phase اللي هو الساكن يعني ما شغال ما
+
+191
+00:16:21,770 --> 00:16:27,490
+بتعمل عملية نضوج وفقط 5% هو اللي شغال وهذه نعمة
+
+192
+00:16:27,490 --> 00:16:32,390
+من نعم الخالق علينا لإنه في عندنا كم هائل من الـ
+
+193
+00:16:32,390 --> 00:16:37,270
+reserves تمثل ومع ذلك من صفاتها أنها بتعمل 
+
+194
+00:16:37,270 --> 00:16:43,430
+continuous self renewal ماذا يميز هاجولنا على
+
+195
+00:16:43,430 --> 00:16:47,800
+سطحها ما.. كيف نتعرف عليها؟ كانوا بنتعرف عليها من
+
+196
+00:16:47,800 --> 00:16:52,840
+خلال cell surface marker بمعنى أنه في علامات على
+
+197
+00:16:52,840 --> 00:16:56,760
+سطح هذه الخلايا وجدوا أن هذه العلامات متميزة بـ CD
+
+198
+00:16:56,760 --> 00:17:02,840
+34 positive 38 negative and lineage negative بمعنى
+
+199
+00:17:02,840 --> 00:17:07,780
+لساتنا مش محددين خط سيرها و HLADR
+
+200
+00:17:17,630 --> 00:17:22,910
+مصطلحات واحدة واحدة بس ببساطة CD يعني cluster of
+
+201
+00:17:22,910 --> 00:17:30,170
+differentiation بمعنى أنه كل الخلايا ماشي cluster
+
+202
+00:17:30,170 --> 00:17:33,610
+مجموعة differentiation مجموعة الخلايا اللي صار لها
+
+203
+00:17:33,610 --> 00:17:37,790
+differentiation CD اختصار ليش cluster of
+
+204
+00:17:37,790 --> 00:17:43,110
+differentiation ماشي وهدب يعني أن كل الخلايا في
+
+205
+00:17:43,110 --> 00:17:47,270
+هذه المرحلة بتكون تحتوي على one marker اللي هو
+
+206
+00:17:47,270 --> 00:17:50,610
+أعطوه رقم 34 هنبدأ نفهمه
+
+207
+00:17:55,190 --> 00:17:59,190
+تعني أربعة و ثلاثين ماليهاش ثمانية و ثلاثين لكنها
+
+208
+00:17:59,190 --> 00:18:03,610
+lineage negative بمعنى أنه لسه ما حددش في خط سيرها والـ
+
+209
+00:18:03,610 --> 00:18:07,830
+HLA هو اختصار لـ human leukocyte antigen اللي من
+
+210
+00:18:07,830 --> 00:18:11,890
+نوع DR مرضه هتحكي عن إيه في المستقبل إن شاء الله والـ
+
+211
+00:18:11,890 --> 00:18:17,530
+RH كلكم بتعرفوا الـ progenitor cell مرحلة تانية
+
+212
+00:18:17,530 --> 00:18:20,690
+حكينا عن الـ stem cell اللي قلنا الـ progenitor cell
+
+213
+00:18:20,690 --> 00:18:26,500
+إيه عبارة عن differentiated Cell يعني بدأت تستغلها
+
+214
+00:18:26,500 --> 00:18:30,720
+differentiation وبدأت تقلل self renewal ability
+
+215
+00:18:30,720 --> 00:18:35,360
+عندها it's multimotential وشوي شوي بتصير
+
+216
+00:18:35,360 --> 00:18:39,960
+unilinear أو committed committed يعني ملتزمة بخط
+
+217
+00:18:39,960 --> 00:18:47,160
+cell بخط إنتاج واحد من الخلايا سميناها commitment
+
+218
+00:18:47,160 --> 00:18:48,340
+يعني ملتزمة
+
+219
+00:18:52,140 --> 00:18:57,080
+نوع واحد من الخلايا لكنها الـ Progenitor بتشكل 3
+
+220
+00:18:57,080 --> 00:19:00,720
+% من الـ Total Nucleated Hemopoietic Cell في الـ bone
+
+221
+00:19:00,720 --> 00:19:05,860
+marrow تقريبًا 3% شوفوا الـ stem cell نصف المية اللي
+
+222
+00:19:05,860 --> 00:19:14,760
+بدأت تزيد هذه صارت 3% من الـ bone marrow stem cell طيب
+
+223
+00:19:14,760 --> 00:19:18,020
+الـ
+
+224
+00:19:18,020 --> 00:19:18,360
+..
+
+225
+00:19:27,410 --> 00:19:31,290
+It forms colonies of cell in semi-solid media يعني
+
+226
+00:19:31,290 --> 00:19:36,730
+إحنا نتعرف عليها in vitro في culture media
+
+227
+00:19:36,730 --> 00:19:41,030
+وبنشوفها على شكل colony forming unit فقط colonies
+
+228
+00:19:42,550 --> 00:19:46,210
+ما نتعرف عليها، ما نديهاش اسمها لأنها كلها زي
+
+229
+00:19:46,210 --> 00:19:51,470
+بعض، كلها لها نفس الشكل، أول هذه الخلايا اللي
+
+230
+00:19:51,470 --> 00:19:55,850
+بتتكون هي CFU يعني كل الـ uniform unit GEMM
+
+231
+00:19:55,850 --> 00:19:58,130
+وقلنا لكوا هذه اختصار لـ جراند سيليز
+
+232
+00:19:58,130 --> 00:20:03,010
+Erythrocytic Monocytic Megakaryocytic Series
+
+233
+00:20:06,860 --> 00:20:09,160
+وطبعًا الـ survival and differentiation of the
+
+234
+00:20:09,160 --> 00:20:12,700
+progenitor cell is influenced by a certain growth
+
+235
+00:20:12,700 --> 00:20:19,220
+factor وهؤلاء الفاكتورز مسمى cytokine بما فيها
+
+236
+00:20:19,220 --> 00:20:21,360
+الـ Interleukin والـ colony stimulating factor
+
+237
+00:20:21,360 --> 00:20:24,600
+الـ Progenitor الـ Progenitor الـ Progenitor الـ Progenitor
+
+238
+00:20:24,600 --> 00:20:27,580
+الـ Progenitor الـ Progenitor الـ Progenitor الـ Progenitor
+
+239
+00:20:27,580 --> 00:20:33,140
+الـ Progenitor الـ Progenitor الـ Progenitor الـ Progenitor
+
+240
+00:20:33,140 --> 00:20:35,020
+الـ Progenitor الـ Progenitor الـ Progenitor الـ Progenitor
+
+241
+00:20:35,020 --> 00:20:36,140
+الـ Progenitor الـ Progenitor الـ Progenitor الـ Progeni
+
+242
+00:20:37,480 --> 00:20:40,900
+maturing blood cell majority of the cell طبعًا معظم
+
+243
+00:20:40,900 --> 00:20:46,860
+الخلايا بتشكل الـ mature blood cell أكثر من 95% من
+
+244
+00:20:46,860 --> 00:20:51,880
+الخلايا it lose adherence receptor قلت لكوا and
+
+245
+00:20:51,880 --> 00:20:55,360
+become deformable قلت لكوا أنه كل ما الخلايا نضجت
+
+246
+00:20:55,360 --> 00:20:59,080
+كل ما تحررت من الـ stromal cell وبدأت تطفو إلى
+
+247
+00:20:59,080 --> 00:21:02,440
+الأعلى ولغاية ما تصل الـ sinusoid الـ sinusoid يعني
+
+248
+00:21:02,440 --> 00:21:05,980
+فتحات العظم وين بتصب هذه الفتحات في الـ
+
+249
+00:21:05,980 --> 00:21:06,660
+peripheral؟
+
+250
+00:21:09,320 --> 00:21:12,780
+Migrate through cytoplasm of lining endothelial
+
+251
+00:21:12,780 --> 00:21:17,780
+cell to intercyanoside تلقائي تصل الـ cyanoside ثم
+
+252
+00:21:17,780 --> 00:21:22,200
+طبعًا ما عدا الـ platelet الـ platelet is are the
+
+253
+00:21:22,200 --> 00:21:25,800
+exception الـ megakaryocytes
+
+254
+00:21:25,800 --> 00:21:32,390
+أصلًا هي موجودة في الـ cyanosida الأول هي خلية كبيرة
+
+255
+00:21:32,390 --> 00:21:36,030
+جدًا ومنع تكون موجودة جوه داخل الـ bone marrow لأنها
+
+256
+00:21:36,030 --> 00:21:40,470
+بتاخد حيز كبير جدا من الـ bone marrow فربنا يحطها
+
+257
+00:21:40,470 --> 00:21:45,430
+جنب الـ sinuses وبالتالي they form a long process
+
+258
+00:21:45,430 --> 00:21:49,770
+of propylated which fragments into some nascent
+
+259
+00:21:49,770 --> 00:21:52,730
+platelets يعني شوي شوي إن شاء الله قدام حاجة أشرح لك
+
+260
+00:21:52,730 --> 00:21:57,670
+كيف تتم عملية الـ mega cardioparesis الـ phenotype
+
+261
+00:21:57,670 --> 00:22:01,150
+تبع الـ hemopoietic stem cell حاكن عليه ده هو
+
+262
+00:22:01,150 --> 00:22:05,130
+positive و negative الـ regulation بتتم من خلال
+
+263
+00:22:05,130 --> 00:22:10,350
+ثلاث عمليات القاتلة نمرا واحد local micro
+
+264
+00:22:10,350 --> 00:22:18,250
+environment control وقلنا الـ local control بتتم
+
+265
+00:22:18,250 --> 00:22:23,850
+من خلال الـ micro environment نفسها ثم الـ humoral
+
+266
+00:22:24,510 --> 00:22:28,410
+regulation اللي هو من خلال الـ growth factor ثم في
+
+267
+00:22:28,410 --> 00:22:32,450
+عامل آخر اللي أيضًا regulate the process وهو الـ
+
+268
+00:22:32,450 --> 00:22:36,470
+apoptosis عملية موت الخلايا طبعًا إذا كانت الخلايا
+
+269
+00:22:36,470 --> 00:22:40,190
+منعناها من الموت بتفضل عايشة فهو عامل أيضًا من
+
+270
+00:22:40,190 --> 00:22:45,010
+العوامل المهمة يبقى ثلاث عوامل أساسية بتعمل
+
+271
+00:22:45,010 --> 00:22:48,470
+regulation للـ hemopoiesis micro environment والـ growth
+
+272
+00:22:48,470 --> 00:22:54,360
+factor والـ apoptosis عوامل اللي بيعملوا طبعًا كيف
+
+273
+00:22:54,360 --> 00:22:57,940
+بتتم عملية الـ regulation of hemopoiesis by growth
+
+274
+00:22:57,940 --> 00:23:02,160
+factor؟ طبعًا هذا الكلام أنا مش راح أشرحه لكم لأن
+
+275
+00:23:02,160 --> 00:23:05,280
+أنتم اخذتو في الـ molecular biology وهو
+
+276
+00:23:05,280 --> 00:23:07,880
+كيفية الارتباط لـ growth factor بالـ receptor تبعه
+
+277
+00:23:07,880 --> 00:23:11,540
+بيصير فيه signal transduction بمعنى أنه بتتولد
+
+278
+00:23:11,540 --> 00:23:16,980
+مجموعة من التفاعلات متى مرتبط بالـ receptor بتتولد
+
+279
+00:23:16,980 --> 00:23:21,200
+مجموعة من التفاعلات أو البروتينات أو الأحداث
+
+280
+00:23:21,200 --> 00:23:25,920
+الداخلية اللي واحد بنشط الثاني والثاني بنشط 
+
+281
+00:23:25,920 --> 00:23:29,640
+التالت لغاية ما نصل إلى الـ nucleus وهناك بيصير
+
+282
+00:23:29,640 --> 00:23:38,940
+فيه وظيفة يسمى عملية الـ signal transduction ماشي
+
+283
+00:23:38,940 --> 00:23:44,180
+قلنا الـ apoptosis عملية مهمة جدا في الـ hemapoiesis
+
+284
+00:23:44,180 --> 00:23:48,560
+قلنا بنعرف الـ apoptosis هو programmed cell death ماشي
+
+285
+00:23:50,360 --> 00:23:57,280
+لكن الخلية ممكن تنجو من موت الـ programmed cell death
+
+286
+00:23:57,280 --> 00:24:01,280
+by specific growth factor by certain gene by 
+
+287
+00:24:01,280 --> 00:24:05,900
+specific antigen and some viruses وهذا برضه أخذته 
+
+288
+00:24:05,900 --> 00:24:09,800
+في الـ molecular biology وهو الـ mechanism of
+
+289
+00:24:09,800 --> 00:24:15,700
+apoptosis وكيفية تنشيط الكاسابيسيز الميكانزم اللي
+
+290
+00:24:15,700 --> 00:24:16,340
+بيؤدي في 
+
+291
+00:24:24,730 --> 00:24:28,950
+death of cell برنامج death of cell برنامج death of
+
+292
+00:24:28,950 --> 00:24:31,130
+cell برنامج death of cell برنامج death of cell
+
+293
+00:24:31,130 --> 00:24:33,970
+برنامج death of cell برنامج death of cell برنامج
+
+294
+00:24:33,970 --> 00:24:35,470
+death of cell برنامج death of cell برنامج death of
+
+295
+00:24:35,470 --> 00:24:37,150
+cell برنامج death of cell برنامج death of cell
+
+296
+00:24:37,150 --> 00:24:37,470
+برنامج death of cell برنامج death of cell برنامج
+
+297
+00:24:37,470 --> 00:24:37,590
+cell برنامج death of cell برنامج death of cell
+
+298
+00:24:37,590 --> 00:24:42,290
+death of cell برنامج death of cell برنامج death of
+
+299
+00:24:42,290 --> 00:24:49,990
+cell برنامج death of cell برنامج death of cell
+
+300
+00:24:49,990 --> 00:24:53,950
+برنامج death of cell برنامج death of cell برنامج إذا
+
+301
+00:24:53,950 --> 00:24:58,470
+صار في خلل بيعمل لنا حالة مرضية مثال عليها الـ
+
+302
+00:24:58,470 --> 00:25:03,470
+chronic lymphocytic leukemia وهذه عبارة عن خلايا
+
+303
+00:25:03,470 --> 00:25:09,090
+بتعمل أو بتقاوم الـ chemotherapy إن
+
+304
+00:25:09,090 --> 00:25:14,550
+شاء الله هنتطرق الليلة للموضوع هذا بالتفصيل في الـ
+
+305
+00:25:14,550 --> 00:25:15,350
+leukemia
+
+306
+00:25:20,690 --> 00:25:24,870
+الـ hemopoiesis بمعنى كيف بتتعرف الـ hemopoiesis 
+
+307
+00:25:24,870 --> 00:25:29,670
+شغالة ولا مش شغالة؟ قالوا they can be assessed by
+
+308
+00:25:29,670 --> 00:25:34,130
+the following  نمرا واحد اعمل CBC طبعا الـ CBC
+
+309
+00:25:34,130 --> 00:25:38,390
+هيبين لك الـ normal ranges of blood cell ولا إذا في
+
+310
+00:25:38,390 --> 00:25:43,050
+الـ normal معناته الـ hemopoietic activity شغالة
+
+311
+00:25:43,050 --> 00:25:48,610
+منيح وإذا مش في الـ normal بعد وفيه خلق يبقى CBC أو 
+
+312
+00:25:48,610 --> 00:25:52,550
+full blood count أو complete blood count  و أحد
+
+313
+00:25:52,550 --> 00:25:57,040
+العوامل أمرا اتنين أفحص الـ bone marrow نفسه طب كيف بتم
+
+314
+00:25:57,040 --> 00:26:02,640
+عملية فحص الـ bone marrow by aspiration ماشي وهذه طبعا
+
+315
+00:26:02,640 --> 00:26:08,600
+بتدينا فكرة عن later stages of maturation of
+
+316
+00:26:08,600 --> 00:26:12,360
+hemopoietic cells لأن و احنا خشينا على الـ bone marrow و
+
+317
+00:26:12,360 --> 00:26:18,230
+شوفنا الخلايا و مراحل نضوجها و بنقدر نفهم خلاص في
+
+318
+00:26:18,230 --> 00:26:22,130
+هذه الحالة نعرف إذا كان الخلايا ماشية صح أو في
+
+319
+00:26:22,130 --> 00:26:26,310
+خلل في النضوج أو واقف في النضوج عند مرحلة معينة و
+
+320
+00:26:26,310 --> 00:26:31,570
+هكذا نمر لثلاثة أنت بدل ما تاخد aspiration تماما
+
+321
+00:26:31,570 --> 00:26:35,490
+ممكن تاخد اللي هو biopsy من الـ bone marrow وهذا
+
+322
+00:26:35,490 --> 00:26:40,350
+بيبين لنا إذا كان الـ bone marrow architecture
+
+323
+00:26:40,350 --> 00:26:47,890
+normal ولا abnormal بمعنى الـ bone marrow في إنتاج أو 
+
+324
+00:26:47,890 --> 00:26:54,350
+مافي إنتاج للـ bone marrow الـ bone marrow aspiration بتتم من
+
+325
+00:26:54,350 --> 00:27:00,910
+هذه المنطقة فده هنا بناخد في عينة 
+
+326
+00:27:00,910 --> 00:27:06,370
+عينة الـ bone marrow من هذه المنطقة وهي هذه المنطقة
+
+327
+00:27:06,370 --> 00:27:12,830
+بيسموها Iliac crest وبما أنها خلفية بينام الواحد
+
+328
+00:27:12,830 --> 00:27:17,590
+على بطنه بيسموها posterior Iliac crest وزي ما
+
+329
+00:27:17,590 --> 00:27:20,570
+انتوا شايفين هذه منطقة عظام الحوض وقلنا
+
+330
+00:27:20,570 --> 00:27:24,610
+الـ bone marrow موجود في العظام العريضة وأحسن مثال ناخد
+
+331
+00:27:24,610 --> 00:27:26,210
+أو نعتمد 
+
+332
+00:27:32,010 --> 00:27:36,110
+الـ Iliac crest هذه أو منطقة الـ sternum الـ sternum 
+
+333
+00:27:36,110 --> 00:27:41,770
+بتعرفوا هي عبارة عن منطقة موجودة في الصدر شايفين 
+
+334
+00:27:41,770 --> 00:27:45,310
+الإبرة لازم تكون حديدية لأن و احنا بدنا نخرج عظم
+
+335
+00:27:45,310 --> 00:27:49,690
+وبالتالي بنخرج العظم و بنزل على الـ hip point و
+
+336
+00:27:49,690 --> 00:27:53,590
+هناك قدامي زي ما انتوا شايفين في Marrow بس جابلي 
+
+337
+00:27:53,590 --> 00:27:57,570
+الـ marrow في skin بدنا نخترقها و
+
+338
+00:28:03,030 --> 00:28:08,650
+bone marrow architecture احنا من خلال الـ biopsy ممكن
+
+339
+00:28:08,650 --> 00:28:11,550
+نشوف إنه الـ bone marrow و architecture is normal ولا لأ
+
+340
+00:28:11,550 --> 00:28:15,150
+يعني cellular ولا not cellular يعني في خلايا ولا
+
+341
+00:28:15,150 --> 00:28:19,730
+مافيش خلايا فيه إذا كان الشكل هذا موجود معناته
+
+342
+00:28:19,730 --> 00:28:23,290
+hypercellular إذا كان الشكل هذا موجود معناته
+
+343
+00:28:23,290 --> 00:28:26,450
+normal cellular وإذا كان زي ما انتوا شايفين follow 
+
+344
+00:28:26,450 --> 00:28:32,330
+fat cell معناته hypocellular ما في إنتاج لمين للـ
+
+345
+00:28:32,330 --> 00:28:32,650
+bone marrow
+
+346
+00:28:35,540 --> 00:28:40,680
+الـ M.E. Ratio هي عبارة عن Myeloid Erythroid Ratio
+
+347
+00:28:40,680 --> 00:28:46,520
+نسبة خلايا الـ Myeloid للإيريثرويد في الـ bone
+
+348
+00:28:46,520 --> 00:28:53,640
+marrow بسموها M.E. Ratio وهي طبيعي وهو أحد عوامل 
+
+349
+00:28:53,640 --> 00:28:57,180
+الـ assessment of bone marrow بمعنى تقييم الـ bone
+
+350
+00:28:57,180 --> 00:29:02,520
+marrow القيمة الطبيعية تبعها من ثلاثة إلى أربعة
+
+351
+00:29:02,520 --> 00:29:08,180
+أضعاف الـ myeloid cell بالنسبة للـ erythroid cell
+
+352
+00:29:08,180 --> 00:29:13,140
+وده طبيعي جدا أنه يكون في هنا صحيح إنه عدد كبير من
+
+353
+00:29:13,140 --> 00:29:16,740
+الـ myeloid أولا من الـ erythroid أولا الـ erythroid
+
+354
+00:29:16,740 --> 00:29:22,060
+حجمها صغير جدا بالنسبة للـ myeloid  نمر اثنين يعني 
+
+355
+00:29:22,060 --> 00:29:26,420
+أقل من النص أو النص  نمر اثنين الـ myeloid عندها عدة
+
+356
+00:29:26,420 --> 00:29:30,930
+أنواع بينما الارثرويد ما هو إلا واحد بالتالي طبيعي جدا 
+
+357
+00:29:30,930 --> 00:29:35,990
+إن الـ myeloid تكون نسبتها أكثر في الـ bone marrow
+
+358
+00:29:35,990 --> 00:29:39,350
+طبعا هذه في بعض الحالات المرضية ممكن نسبة هذه
+
+359
+00:29:39,350 --> 00:29:45,690
+تنعكس على سبيل المثال ومن خلالها بنقدر نقيم الـ 
+
+360
+00:29:45,690 --> 00:29:51,140
+bone marrow normal plates المنتج النهائي للخلايا زي
+
+361
+00:29:51,140 --> 00:29:56,480
+ما أنتم شايفين في عندنا immature طبعا هذه band 
+
+362
+00:29:56,480 --> 00:30:00,940
+نيوتروفيل وأنا بعرف إنكم أخذتم الـ differential
+
+363
+00:30:00,940 --> 00:30:06,800
+في المقدمة وحتاخذوه إن شاء الله في علم الدم العملي
+
+364
+00:30:06,800 --> 00:30:11,400
+هذه eosinophil هذه segmented neutropil basophil
+
+365
+00:30:11,400 --> 00:30:15,840
+large lymphocytes and monocytes النوع مختلفة من
+
+366
+00:30:15,840 --> 00:30:16,200
+إيش
+
+367
+00:30:19,280 --> 00:30:25,120
+ونصل للـ Erythropoiesis قلت لكم أنا الخلايا بتمر
+
+368
+00:30:25,120 --> 00:30:29,180
+في أربع مراحل أساسية الأولى stem cell ثم 
+
+369
+00:30:29,180 --> 00:30:34,020
+progenitor cell ثم precursor cell اللي بتوصلنا للـ
+
+370
+00:30:34,020 --> 00:30:38,360
+recognizable form بمعنى نصل لمرحلة أن الخلايا
+
+371
+00:30:38,360 --> 00:30:43,760
+بتصير لها أسماء نقدر نميز بين الخلايا المختلفة 
+
+372
+00:30:43,760 --> 00:30:47,400
+عشان نصل في النهاية لـ mature form of cell في
+
+373
+00:30:47,400 --> 00:30:49,380
+الـ erythropoiesis قالوا
+
+374
+00:30:54,920 --> 00:30:58,400
+بنكون.. بنشوف أول خلية بيسموها Pro-erythroplast 
+
+375
+00:30:58,400 --> 00:31:07,080
+ثم بعد ذلك تندش وتمر في ست مراحل مختلفة كل مرحلة
+
+376
+00:31:07,080 --> 00:31:12,360
+لازم فبالتالي أول مرحلة هي Pro-erythroplast ثم
+
+377
+00:31:12,360 --> 00:31:20,460
+Erythroplast بتتكون من ثلاثة أنواع إن هو الأولاني
+
+378
+00:31:20,460 --> 00:31:23,960
+بيزوفيليك والثاني polychromatophilic والثالث
+
+379
+00:31:23,960 --> 00:31:28,900
+orthochromatic erythroplast ماشي يعني ثلاثة أو 
+
+380
+00:31:28,900 --> 00:31:32,560
+واحدة جديدة صاروا أربع المرحلة الخامسة هي
+
+381
+00:31:32,560 --> 00:31:37,040
+reticulocyte ثم المرحلة السادسة هي mature
+
+382
+00:31:37,040 --> 00:31:47,180
+erythroplast ماشي وهذا هي الأشكال المختلفة أيها
+
+383
+00:31:47,180 --> 00:31:52,470
+proerythroplast أو بيسموها بعض مرات pronormoblast
+
+384
+00:31:52,470 --> 00:31:59,770
+ثم النورموبلاست اللي هم ثلاثة أو الـ erythroblast اللي
+
+385
+00:31:59,770 --> 00:32:03,510
+هم ثلاثة بيزوفيليك وبوليكروماتيك والـ
+
+386
+00:32:03,510 --> 00:32:09,950
+orthochromic ثم الـ .. هاي المرحلة الأخيرة من الـ
+
+387
+00:32:09,950 --> 00:32:13,150
+orthochromic ثم بعد ذلك الـ reticulocyte والـ 
+
+388
+00:32:13,150 --> 00:32:19,140
+mature ماشي ويسبق هذه العوامل زي ما قلت لكم إن
+
+389
+00:32:19,140 --> 00:32:25,340
+الخلية بتكون غير معروفة ما نقدرش نديها اسم يعني، ماشي
+
+390
+00:32:25,340 --> 00:32:28,300
+طب كيف نتعرف عليها؟ إنه فيها hemopoiesis جالها by 
+
+391
+00:32:28,300 --> 00:32:31,600
+culture technique بنشوفها يعني إيه؟ الخلية
+
+392
+00:32:31,600 --> 00:32:36,980
+الاستم سيل لو أخذناها وزرعناها في مرحلة مقتقدمة في
+
+393
+00:32:36,980 --> 00:32:40,540
+culture media هتديني burst forming unit الـ burst
+
+394
+00:32:40,540 --> 00:32:45,970
+معناتها انفجار بتعمل انفجار كبير من الخلايا
+
+395
+00:32:45,970 --> 00:32:51,630
+وفي هذه الحالة تدينا thousands of nucleated 
+
+396
+00:32:51,630 --> 00:32:58,350
+erythroid in vitro in culture يعني و under some
+
+397
+00:32:58,350 --> 00:33:03,210
+changes it become colony forming unit erythroid
+
+398
+00:33:03,210 --> 00:33:07,070
+يعني بنضيف لها هرمون الـ erythropoietin فبالتالي
+
+399
+00:33:07,070 --> 00:33:11,490
+بتتطور لغاية ما تصل لـ colony forming unit أو في
+
+400
+00:33:11,490 --> 00:33:13,730
+هذه المرحلة بيكون الـ controller
+
+401
+00:33:18,760 --> 00:33:22,920
+هي الـ colony forming unit صارت well differentiated 
+
+402
+00:33:22,920 --> 00:33:30,040
+present only in red bone marrow كان form up to 40
+
+403
+00:33:30,040 --> 00:33:35,980
+.. 64 nucleated erythroid precursors والهرمون
+
+404
+00:33:35,980 --> 00:33:41,280
+اللي بيتحكم فيها الـ erythropoietin لغاية الآن
+
+405
+00:33:41,280 --> 00:33:45,540
+ما نقدرش نميز بينهم except in vitro culture method
+
+406
+00:33:47,090 --> 00:33:50,770
+الآن بنجي لـ recognizable fold هو أول مرحلة 
+
+407
+00:33:50,770 --> 00:33:56,170
+normal blast precursor وهذه حجمه كبير 15-20
+
+408
+00:33:56,170 --> 00:33:59,770
+مايكرون الـ cytoplasm زي ما أنتم شايفينه ديب
+
+409
+00:33:59,770 --> 00:34:05,810
+violet to blue لازالت الخلية غير قادرة على إنتاج
+
+410
+00:34:05,810 --> 00:34:12,810
+الـ hemoglobin فيها nucleus كبيرة بشكل حجم عامل 12 
+
+411
+00:34:12,810 --> 00:34:13,470
+مايكرون
+
+412
+00:34:16,660 --> 00:34:24,680
+وبتملى حوالي ثلاثة أرباع الخلية والـ nucleus has
+
+413
+00:34:24,680 --> 00:34:31,840
+fine-stemmed لازالت الـ DNA تبعها is fine منقطة 
+
+414
+00:34:31,840 --> 00:34:36,140
+stemmed articulate ولو طلعنا هنلاقي في many
+
+415
+00:34:36,140 --> 00:34:38,500
+nuclei موجودة 
+
+416
+00:34:41,530 --> 00:34:44,730
+ثم ما قلت لكم تنتقل إلى normal blast والـ normal 
+
+417
+00:34:44,730 --> 00:34:46,890
+blast ثلاثة مراحل أول هذه المراحل اللي هي الـ
+
+418
+00:34:46,890 --> 00:34:50,450
+mesophilic تبدأ تصغر الخلية وخذوها قاعدة كل ما
+
+419
+00:34:50,450 --> 00:34:54,110
+كانت الخلية mature كل ما كانت كبيرة وكل ما صارت 
+
+420
+00:34:54,110 --> 00:34:57,830
+mature كل ما بدأت تصغر شوية شوية شوية لغاية ما تصل 
+
+421
+00:34:57,830 --> 00:35:04,210
+إلى ال mature form smaller size shows active
+
+422
+00:35:04,210 --> 00:35:11,550
+mitosis no nuclei in the nucleus fine chromatin
+
+423
+00:35:11,550 --> 00:35:17,510
+network وبدأ يظهر شوية condensation في هذه
+
+424
+00:35:17,510 --> 00:35:22,450
+المرحلة بيبدأ تصنيع ال hemoglobin لكنه still is
+
+425
+00:35:22,450 --> 00:35:31,010
+not seen ليش؟ لأن ال cytoplasm is still mesophilic
+
+426
+00:35:31,010 --> 00:35:35,280
+ال intermediate نورموبلاست اللي سميناها
+
+427
+00:35:35,280 --> 00:35:41,240
+polychromatophilic نورموبلاست حجمها نزل ل 10-14
+
+428
+00:35:41,240 --> 00:35:46,380
+مايكرومتر it shows active mitosis، hemoglobin
+
+429
+00:35:46,380 --> 00:35:50,260
+content is increased وهي بالتالي بدأ يلون في الـ
+
+430
+00:35:50,260 --> 00:35:53,400
+cytoplasm تبع الخلية فصار متعدد الألوان
+
+431
+00:35:53,400 --> 00:35:58,380
+polychromatophilic ثم أخر مرحلة من مراحل
+
+432
+00:35:58,380 --> 00:36:04,540
+نورموبلاست نسميها Orthochromic Normoblast شايفين
+
+433
+00:36:04,540 --> 00:36:10,960
+كده نزل حجمها؟ 7 إلى 10 مايكرومتر من 15 إلى 20 ثم
+
+434
+00:36:10,960 --> 00:36:18,680
+نزلت 10 إلى 15 ثم داينا وصلنا إلى مرحلة كان صار
+
+435
+00:36:18,680 --> 00:36:23,600
+حجم الخلية فيها 7 إلى 10 مايكرومتر نيوكلياس شرينكز
+
+436
+00:36:23,600 --> 00:36:27,560
+تبدأ النيوكلياس أنه يصير لها shrinking and condensed
+
+437
+00:36:27,560 --> 00:36:30,140
+ماشي كروماتين material
+
+438
+00:36:35,660 --> 00:36:40,640
+الـ Cartwheel-shaped cell والـ cytoplasm بيصير
+
+439
+00:36:40,640 --> 00:36:44,440
+أزينوفيلك in appearance وزي ما أنتم شايفين هي الـ
+
+440
+00:36:44,440 --> 00:36:51,320
+nucleus بدأت تأخذ موضع طرفي استعدادا إلى خروجها من
+
+441
+00:36:51,320 --> 00:36:56,620
+الخلية لأن الـ erythrocytes is enucleated enucleated يعني
+
+442
+00:36:56,620 --> 00:37:00,960
+ما فيها nucleus طبعا ال reticulocyte هي الخلية ال
+
+443
+00:37:00,960 --> 00:37:06,830
+penultimate يعني ما قبل النهائية ال stage and it
+
+444
+00:37:06,830 --> 00:37:10,450
+has fine network of reticula خلاص انطردت ال
+
+445
+00:37:10,450 --> 00:37:18,410
+nucleus برا لكن ده البقايا ماشي RNA remnant of RNA
+
+446
+00:37:18,410 --> 00:37:23,410
+بيديها ال mesophilic appearance لل cytoplasm في
+
+447
+00:37:23,410 --> 00:37:30,690
+الأطفال بتشوفها بكميات بتوصل من 2 ل 6 لكن
+
+448
+00:37:33,420 --> 00:37:36,720
+إلى أقل من واحد يعني بتشوفها في ال peripheral
+
+449
+00:37:36,720 --> 00:37:39,440
+blood نعم بتشوفها في ال peripheral blood لأن هي
+
+450
+00:37:39,440 --> 00:37:45,180
+مرحلة ما قبل ايش ما قبل ال erythrocyte وبنشوفها
+
+451
+00:37:45,180 --> 00:37:49,080
+بكثرة في حالات الانيميا لأنه بتكون بزيد الطلب على
+
+452
+00:37:49,080 --> 00:37:54,120
+ال RBCs وبالتالي بتبدأ تنزل ال RBCs بدري فبنشوف
+
+453
+00:37:54,120 --> 00:37:59,780
+مراحل ما قبل ال erythrocyte في ال peripheral blood كتير
+
+454
+00:37:59,780 --> 00:38:04,490
+وهي شكلها بعد شهور RBCs كنا بنعرف هي عبارة عن
+
+455
+00:38:04,490 --> 00:38:08,830
+بايكون كيف ديسك شكلها مش فيها نيوكلياس وهي حوالي
+
+456
+00:38:08,830 --> 00:38:15,850
+ثلثها مليان بالهيموجلوبين وهذه المراحل الستة اللي
+
+457
+00:38:15,850 --> 00:38:20,090
+بتمر فيها الخلية during erythropoiesis وهي
+
+458
+00:38:20,090 --> 00:38:23,470
+بيسموها أيها proerythroblast, mesophilic ثم
+
+459
+00:38:23,470 --> 00:38:29,090
+polychromatic ثم orthochromic ثم reticulocyte بعد
+
+460
+00:38:29,090 --> 00:38:35,820
+ما تطلع النيوكلياس من الخلية ثم الـ mature RBCs
+
+461
+00:38:35,820 --> 00:38:40,260
+ثاني، ايش ال physiology of erythropoiesis؟ قالوا
+
+462
+00:38:40,260 --> 00:38:43,620
+فيه أربعة mitotic divisions ما بين الـ
+
+463
+00:38:43,620 --> 00:38:47,960
+pronormoblast اللي هي أول مرحلة وال orthochromic
+
+464
+00:38:47,960 --> 00:38:56,940
+normoblast الأربعة بدون ست عشر RBCs لكن مش كل الست
+
+465
+00:38:56,940 --> 00:39:07,320
+عشر هيصلوا إلى ال mature في منهم بيخلق تخليق خاطئ
+
+466
+00:39:07,320 --> 00:39:13,420
+and this will be destroyed وعملية ال destruction
+
+467
+00:39:13,420 --> 00:39:18,840
+لهذه الخلايا بيسموها ineffective erythropoiesis يعني
+
+468
+00:39:18,840 --> 00:39:24,660
+erythropoiesis غير فعالة يبقى أثناء عملية الإنتاج في
+
+469
+00:39:24,660 --> 00:39:33,850
+عندنا خلايا بتنتج لكنها غير سليمة ومطلوب من الجسم
+
+470
+00:39:33,850 --> 00:39:37,250
+أنه يخلصنا منها وبالفعل بيصير عملية destruction
+
+471
+00:39:37,250 --> 00:39:40,530
+لهذه الخلايا وبيسموه العملية ineffective
+
+472
+00:39:40,530 --> 00:39:46,010
+erythropoiesis قد ايش بتاخد العملية وجدت أنها بتاخد
+
+473
+00:39:46,010 --> 00:39:51,370
+من اتنين لسبعة أيام من ال pronormoblast لغاية ال
+
+474
+00:39:51,370 --> 00:39:56,370
+mature to mature into orthochromatic بعد هيك بتاخد
+
+475
+00:39:56,370 --> 00:40:00,750
+يوم زيادة عشان تطرد ال nucleus
+
+476
+00:40:03,610 --> 00:40:08,130
+وبنصل إلى مرحلة reticulocytes اللي بتاخد من يومين
+
+477
+00:40:08,130 --> 00:40:15,550
+لتلات أيام في ال bone marrow عشان تندج ماشي بعد هيك
+
+478
+00:40:15,550 --> 00:40:22,610
+بتنزل على ال peripheral blood تقعد الخلية 120 يوم
+
+479
+00:40:22,610 --> 00:40:26,350
+في ال peripheral blood as normal functioning
+
+480
+00:40:26,350 --> 00:40:31,770
+erythrocytes ودي المراحل اللي هي ال phasesأي أساسها
+
+481
+00:40:31,770 --> 00:40:39,250
+من الأول stem cell بعد هي انقسمت ودّتني committed
+
+482
+00:40:39,250 --> 00:40:43,370
+cell ايش يعني committed يعني التزمت بخط إنتاج ال
+
+483
+00:40:43,370 --> 00:40:50,470
+RBCs فبدأت تديني proerythroblast ثم في عندنا ايش
+
+484
+00:40:50,470 --> 00:40:58,420
+Mitotic يعني ال phases أول phase بتصير early
+
+485
+00:40:58,420 --> 00:41:02,460
+erythropoiesis ثم الفيز الثاني في late
+
+486
+00:41:02,460 --> 00:41:05,020
+erythropoiesis وفي هذا الفيز بنشوف hemoglobin
+
+487
+00:41:05,020 --> 00:41:09,540
+accumulation هذا هي لغاية ما نصل للفيز الثالث وهو
+
+488
+00:41:09,540 --> 00:41:14,960
+ال ejection أو النيكلياس تطرد من الخلية
+
+489
+00:41:14,960 --> 00:41:22,700
+ما هي العوامل التي تؤثر أو تتحكم في عملية ال
+
+490
+00:41:22,700 --> 00:41:25,740
+erythropoiesis دلوقتي فيها أكثر عوامل أهم هذه
+
+491
+00:41:25,740 --> 00:41:30,760
+العوامل هو tissue oxygenation احنا عارفين ان ال
+
+492
+00:41:30,760 --> 00:41:37,580
+RBCs وظيفتها هي حمل ال oxygen فبالتالي ال oxygen
+
+493
+00:41:37,580 --> 00:41:45,360
+هو عامل مهم في عملية إنتاج أو التحكم في إنتاج ال
+
+494
+00:41:45,360 --> 00:41:51,260
+RBCs ثم first promoting activity هذا الـhormone
+
+495
+00:41:51,260 --> 00:41:54,200
+بيتحكم في أول مرحلة من المراحل اللي are
+
+496
+00:41:54,200 --> 00:42:00,540
+erythropoiesis ثم ال erythropoietin بيتحكم في كل مراحل
+
+497
+00:42:00,540 --> 00:42:04,380
+ما بعد ذلك حتى في بعض المقالات بتقول أنه بيتحكم
+
+498
+00:42:04,380 --> 00:42:09,040
+بال function of mature RBCs وفي مقالات بتقول لأ
+
+499
+00:42:09,040 --> 00:42:14,480
+لغاية ال mature وبس ثم ال iron هو ال
+
+500
+00:42:14,480 --> 00:42:18,400
+iron ملزمة في تصنيع ال hemoglobin فإذا كان خلية
+
+501
+00:42:18,400 --> 00:42:20,840
+بدها تصنع hemoglobin إذا ما فيش iron كده بدها تصنع
+
+502
+00:42:20,840 --> 00:42:27,660
+فبتتأثر في RBCs ثم ال vitamin ملزمة ال vitamin
+
+503
+00:42:27,660 --> 00:42:33,220
+B12 and folic acid عشان DNA synthesis وبعض العوامل
+
+504
+00:42:33,220 --> 00:42:39,240
+الأخرى زي ال copper وال zinc و ال magnesium sorry ال
+
+505
+00:42:39,240 --> 00:42:43,640
+erythropoietin هو عبارة عن hormone كلنا بينتج من
+
+506
+00:42:43,640 --> 00:42:48,800
+الكلى هو عبارة عن glycoprotein substance واليوم
+
+507
+00:42:48,800 --> 00:42:56,240
+موجود منه أدوية صناعية إبر صناعية يعني مصنع by
+
+508
+00:42:56,240 --> 00:43:01,220
+يعني
+
+509
+00:43:01,220 --> 00:43:07,760
+مصانع خارجية بيشتغل على ال colony forming unit
+
+510
+00:43:07,760 --> 00:43:12,200
+erythroid منها لغاية الآخر وظيفته الأساسية
+
+511
+00:43:12,200 --> 00:43:16,000
+increase the number of nucleated precursor in the
+
+512
+00:43:16,000 --> 00:43:19,280
+bone marrow و
+
+513
+00:43:20,660 --> 00:43:23,880
+زي ما قلت لكم ده هو الـ reticulocyte الـ mature
+
+514
+00:43:23,880 --> 00:43:29,660
+RBCs in the blood بيبدأ يزيد عددها وفيتامين أهمه
+
+515
+00:43:29,660 --> 00:43:33,940
+vitamin B12 إن شاء الله هناخده بالتفصيل قدام وهو
+
+516
+00:43:33,940 --> 00:43:37,500
+عبارة عن الـ cyanocobalamin وال folic acid
+
+517
+00:43:37,500 --> 00:43:42,640
+التانين بلزموه ك vitamins في هذه العملية واحد
+
+518
+00:43:42,640 --> 00:43:47,760
+بيسموه Extrinsic factor of Castle وبيحتاج إلى
+
+519
+00:43:47,760 --> 00:43:53,490
+Intrinsic factor وهو إن شاء الله هنحكي فيه بالتفصيل
+
+520
+00:43:53,490 --> 00:43:58,050
+قدام وإذا ما فيش Intrinsic factor بيصير فيه حاجة
+
+521
+00:43:58,050 --> 00:44:01,270
+بيسموها pernicious anemia وهي نوع من أنواع ال
+
+522
+00:44:01,270 --> 00:44:06,670
+megaloblastic anemia ال vitamin أيضا stimulate
+
+523
+00:44:06,670 --> 00:44:11,370
+erythropoiesis ووجدوا أن هذه ال vitamin موجودة في
+
+524
+00:44:11,370 --> 00:44:16,010
+ال meat وال dairy products ال iron ضروري جدا في
+
+525
+00:44:16,010 --> 00:44:19,690
+تصنيع ال hemoglobin غيابه بيعمل microcytic
+
+526
+00:44:19,690 --> 00:44:25,670
+hypochromic anemia وتبدأ تتأثر ال blood indices
+
+527
+00:44:25,670 --> 00:44:34,950
+ال MCV وال MCH وال MCHC are low وعملية ال
+
+528
+00:44:34,950 --> 00:44:39,010
+regulation بالتمثيل الغذائي لاحظوا هاي ال aerosol
+
+529
+00:44:39,010 --> 00:44:43,250
+protein هاي ال aerosol protein بالأخضر الـ
+
+530
+00:44:43,250 --> 00:44:45,810
+regulation بتتم من فوق الـ colon stimulating
+
+531
+00:44:45,810 --> 00:44:49,270
+factor الـ colon forming unit ال erythroid وهي
+
+532
+00:44:49,270 --> 00:44:54,030
+ال proerythroblast ثم erythroblast ثم mature طب ايش
+
+533
+00:44:54,030 --> 00:44:58,530
+اللي بيصير؟ قالوا لما هذه العواملات قل tissue
+
+534
+00:44:58,530 --> 00:45:03,430
+oxygenation is decreased ووقت ايش بيصير عملية
+
+535
+00:45:03,430 --> 00:45:09,230
+decreasing لل oxygen زي في حالة ال hypovolemia
+
+536
+00:45:12,220 --> 00:45:15,640
+الـ poor blood flow أو في حالات الـ pulmonary
+
+537
+00:45:15,640 --> 00:45:22,080
+disease شو اللي بيصير بيقل الأكسجين فلما يقل
+
+538
+00:45:22,080 --> 00:45:27,380
+الأكسجين تتحسس الكلى قلة الأكسجين فبتروح تيام تطلع
+
+539
+00:45:27,380 --> 00:45:32,820
+ال erythropoietin شو بيعمل ال erythropoietin؟ قالوا بيشتغل
+
+540
+00:45:32,820 --> 00:45:36,600
+على عملية ال erythropoiesis من الأول على ال colon
+
+541
+00:45:36,600 --> 00:45:43,320
+forming unit ال erythroid ومبدأش بيبدأ يزودها المحصلة
+
+542
+00:45:43,320 --> 00:45:50,180
+زيادة في إنتاج ال RBCs ومتى ما زادت ال RBCs في
+
+543
+00:45:50,180 --> 00:45:55,360
+العدد بتحمل أكسجين أكثر وبالتالي بتقل عملية ال
+
+544
+00:45:55,360 --> 00:46:02,820
+decrease in tissue oxygenation ال erythropoietin وظاهته
+
+545
+00:46:02,820 --> 00:46:09,010
+activated stem cell of bone marrow shortening cell
+
+546
+00:46:09,010 --> 00:46:13,570
+cycle ضروري جدا عشان نسرع في عملية إنتاج ال RBCs
+
+547
+00:46:13,570 --> 00:46:18,550
+ثم Decrease maturation time بدل ما تاخد وقت كبير
+
+548
+00:46:18,550 --> 00:46:22,890
+في عملية ال maturation بيصير قليل ثم Increase rate
+
+549
+00:46:22,890 --> 00:46:28,410
+of mitosis and maturation process السرعة بتزيد
+
+550
+00:46:28,410 --> 00:46:34,860
+Increase rate of hemoglobin أيضا سرعة إنتاج
+
+551
+00:46:34,860 --> 00:46:39,560
+الهيموجلوبين المزيد تسبب في تنزيل عدد ال reticulocyte 
+
+552
+00:46:39,560 --> 00:46:44,580
+بكمية
+
+553
+00:46:44,580 --> 00:46:51,560
+أكبر ومن أهم وظائفه أيضا تمنع ال apoptosis وده
+
+554
+00:46:51,560 --> 00:46:55,480
+ال erythropoietin receptor وده زي ما أنتم شايفين
+
+555
+00:46:58,110 --> 00:47:01,670
+هو يتكون ويرتبط بالـ Ligand تبعه وهو الـ Receptor
+
+556
+00:47:01,670 --> 00:47:07,010
+وهو الـ Ligand فبيبدأ يتنشط سلسلة من ال
+
+557
+00:47:07,010 --> 00:47:11,510
+Transcriptional Factor اللي في النهاية بتزود لنا
+
+558
+00:47:11,510 --> 00:47:15,090
+عملية ال erythropoiesis
+
+559
+00:47:18,140 --> 00:47:22,000
+هذا ما يخص الـ erythropoiesis، الـ Granulopoiesis
+
+560
+00:47:22,000 --> 00:47:27,460
+نفس الحكاية، بدها تديني اللي هو الـ Granulocyte
+
+561
+00:47:27,460 --> 00:47:30,820
+وهي الإيوزينوفيل والنيوتروفيل والبيزوفيل
+
+562
+00:47:33,880 --> 00:47:38,200
+والعملية بتتم بنفس الحالة بتمر في 6 مراحل مختلفة
+
+563
+00:47:38,200 --> 00:47:44,780
+أول مرحلة هي الـ blast ثم promyelocyte ثم
+
+564
+00:47:44,780 --> 00:47:49,960
+myelocyte ثم metamyelocyte ثم الـ band ثم segmented
+
+565
+00:47:49,960 --> 00:47:56,180
+cell ماشي فهي المراحل المختلفة الستة ننتقل في الـ
+
+566
+00:47:56,180 --> 00:48:01,940
+maturation أو أول مرحلة هي الـ myeloblast و
+
+567
+00:48:05,590 --> 00:48:11,990
+تأخذ من 24 إلى 48 ساعة per single cycle بتمثل أقل
+
+568
+00:48:11,990 --> 00:48:15,130
+من 1% من الـ bottom of the compartment الخلايا
+
+569
+00:48:15,130 --> 00:48:21,410
+كبيرة 15 إلى 20 مايكرون نوكليولايين و nucleus is
+
+570
+00:48:21,410 --> 00:48:25,620
+delicate, small amount of cytoplasm with rough
+
+571
+00:48:25,620 --> 00:48:29,360
+endoplasmic reticulum بالمناسبة يا بنات ويا شباب
+
+572
+00:48:29,360 --> 00:48:33,860
+هذا الكلام هتاخدوه بالتفصيل الممل إن شاء الله في
+
+573
+00:48:33,860 --> 00:48:37,940
+العمل فما تجلجلوش من صفات هذه الخلايا هذه بدها حفظ
+
+574
+00:48:37,940 --> 00:48:42,940
+صحيح عشان تبدأ تتعرف على الخلية من شكلها لكن
+
+575
+00:48:42,940 --> 00:48:47,220
+هانشاء الله المعلومات هذه العمل يحتاج تثبيت فيها
+
+576
+00:48:55,290 --> 00:48:58,910
+المرحلة اللي بعدها Myeloblast وقلنا هذه عبارة عن
+
+577
+00:48:58,910 --> 00:49:00,830
+cytochemical staining shows presence of
+
+578
+00:49:00,830 --> 00:49:05,410
+myeloperoxidase بيبدأ يتكون أول أنواع الـ granules
+
+579
+00:49:05,410 --> 00:49:08,590
+لأن هذه عبارة عن granular size وأول أنواع الـ
+
+580
+00:49:08,590 --> 00:49:10,870
+granules بيسموها primary granules تحتوي على
+
+581
+00:49:10,870 --> 00:49:20,330
+myeloperoxidase وهذه من أهم من وظائفها وهي اللي
+
+582
+00:49:21,780 --> 00:49:27,540
+لقتل الـ intracellular killing لأي microbe وضروري
+
+583
+00:49:27,540 --> 00:49:31,660
+جدا الـ killing أو الدفاع على نفسها يعني الخلية
+
+584
+00:49:31,660 --> 00:49:35,900
+بتدافع على نفسها في مراحل مبكرة جدا الـ myeloplast
+
+585
+00:49:35,900 --> 00:49:40,040
+is incapable of motility غير قادر على الحركة and
+
+586
+00:49:40,040 --> 00:49:44,560
+adhesion and phagocytosis is therefore non-
+
+587
+00:49:44,560 --> 00:49:50,450
+functional لساتها غير قادرة على الحركةالأولى على الـ
+
+588
+00:49:50,450 --> 00:49:57,890
+adhesion ننتقل إلى promyelocytes وهذه تحتاج برضه
+
+589
+00:49:57,890 --> 00:50:04,230
+بعد أكتر من يوم من الـ blast stage بتخش الخلية في
+
+590
+00:50:04,230 --> 00:50:09,950
+مرحلة الـ promyelocytes تشكل 1 ل 5% و الـ size is
+
+591
+00:50:09,950 --> 00:50:18,510
+more than الـ Myeloplast و هذه هي القاعدة بتشذ هنا
+
+592
+00:50:18,510 --> 00:50:22,250
+فقط في هذه المرحلة احنا قلنا ان الخلية كل ما صارت
+
+593
+00:50:22,250 --> 00:50:26,670
+more mature كل ما نضجت كل ما زغرت إلا أنه في هذه
+
+594
+00:50:26,670 --> 00:50:33,390
+المرحلة المرحلة هذه أكبر من إيش من سابقتها Nuclear
+
+595
+00:50:33,390 --> 00:50:36,310
+chromatin may be delicate or may show clumping, 
+
+596
+00:50:36,530 --> 00:50:41,470
+nuclei begin to fade بنبطل نشوفها موجودة لكن وإيش
+
+597
+00:50:41,470 --> 00:50:46,930
+بنبطل نشوفها أذكركم المراحل المختلفة اللي بعدها
+
+598
+00:50:46,930 --> 00:50:52,730
+هيصير في myelocytes وهنا بيبدأ يصير في تكوين الـ
+
+599
+00:50:52,730 --> 00:50:58,250
+neutrophilic granules وبالذات الـ secondary
+
+600
+00:50:58,250 --> 00:51:04,670
+granules والـ myelocyte is the last cell of bone
+
+601
+00:51:04,670 --> 00:51:06,790
+marrow compartment capable of mitosis
+
+602
+00:51:09,700 --> 00:51:16,980
+بتاخد حوالي أربع على خمس أيام وتبدأ الخلية تاخد
+
+603
+00:51:16,980 --> 00:51:20,560
+distinct morphological variability لأنه في هذه
+
+604
+00:51:20,560 --> 00:51:24,060
+المرحلة بما أنه بتتكون secondary granules وكل
+
+605
+00:51:24,060 --> 00:51:29,740
+granules بيختلف عن التانية بالنسبة للاختلاف
+
+606
+00:51:29,740 --> 00:51:36,220
+الخلايا فالـ neutrophil فيها بتاخد شكل معين ثم الـ
+
+607
+00:51:36,220 --> 00:51:40,950
+eosinophil شكل تاني ثم الـ basophil وبالتالي في هذه
+
+608
+00:51:40,950 --> 00:51:44,410
+المرحلة تبدأ الخلية في التشكل يعني بتاخد أكتر من
+
+609
+00:51:44,410 --> 00:51:51,830
+شكل تبدأ تصغر 12 ل 18 مايكرون تشكل أقل من 10%
+
+610
+00:51:51,830 --> 00:51:56,550
+nucleus is round to oval تبدأ تصير فيه flattening
+
+611
+00:51:56,550 --> 00:52:04,650
+في side near the Golgi apparatus nuclear chromatin
+
+612
+00:52:04,650 --> 00:52:08,140
+shows clumping بدأ تصير فيه analog عندما لا يزال
+
+613
+00:52:08,140 --> 00:52:15,960
+نوكليولاية مظهرة. وبعدها بيجي الـ myelocytes، في
+
+614
+00:52:15,960 --> 00:52:21,460
+metamyelocytes، ناشي، بس ده هنا قبل ما نخش على
+
+615
+00:52:21,460 --> 00:52:24,800
+metamyelocytes، هي secondary granule stains pink
+
+616
+00:52:29,190 --> 00:52:32,970
+يعني بدأت تتمييز or pinkish plush within the
+
+617
+00:52:32,970 --> 00:52:38,390
+cytoplasm شكل الـ pink الزهري compounds such as
+
+618
+00:52:38,390 --> 00:52:41,090
+alkaline phosphatase لو فحصنا الـ granules هلاجي
+
+619
+00:52:41,090 --> 00:52:45,630
+فيها alkaline phosphatase في الـ secondary granules
+
+620
+00:52:45,630 --> 00:52:50,600
+دليل على وجود إيش secondary granules وفي هذه
+
+621
+00:52:50,600 --> 00:52:56,200
+المرحلة بتبدأ تكتسب وواحدة من الوظائف اللي هي تاعة الـ
+
+622
+00:52:56,200 --> 00:53:00,960
+neutrophil وهي الـ motility لأن هي وظيفتها بعد هيك
+
+623
+00:53:00,960 --> 00:53:05,280
+حصلت في phagocytosis فلازم تتحرك باتجاه الـ antigen و
+
+624
+00:53:05,280 --> 00:53:10,340
+تقتله زي ما قلتلكوا ده هي المراحل في هذه المرحلة
+
+625
+00:53:10,340 --> 00:53:14,000
+صار في عندنا من الـ promyelocytes صار في عندنا
+
+626
+00:53:14,000 --> 00:53:17,780
+Neutrophilic Myelocytes وEosinophilic Myelocytes
+
+627
+00:53:17,780 --> 00:53:21,400
+وBasophilic Myelocytes وزي ما قلتلكوا السبب في
+
+628
+00:53:21,400 --> 00:53:28,180
+اختلاف الخلايا أو الأشكال هذه هو الـ secondary
+
+629
+00:53:28,180 --> 00:53:32,480
+granules اللي بتكون كل granule بياخد شكل معين
+
+630
+00:53:32,480 --> 00:53:36,540
+وبيميز الخلية بتميز معين
+
+631
+00:53:39,680 --> 00:53:44,000
+والبيزوفيل والبيزوفيل زي ما قلتلكوا بعد الـ myelocyte
+
+632
+00:53:44,000 --> 00:53:47,640
+في metamyelocyte زاد عددها من تلاتاشر لاتنين وعشرين
+
+633
+00:53:47,640 --> 00:53:52,640
+في المية صغير حجمها not seen in normal blood لغاية
+
+634
+00:53:52,640 --> 00:53:57,400
+الآن ممنوع نشوفها في الـ peripheral blood it's not
+
+635
+00:53:57,400 --> 00:54:02,880
+fully functioning بعد
+
+636
+00:54:02,880 --> 00:54:09,670
+هيك في الـ band ودي عبارة عن مرحلة ما بين الـ Mature
+
+637
+00:54:09,670 --> 00:54:13,510
+Form of Metamyelocytes هي بيسموها Transitional Form
+
+638
+00:54:13,510 --> 00:54:18,090
+وغالبا موجودة في both peripheral blood and bone
+
+639
+00:54:18,090 --> 00:54:27,230
+marrow وبتعتبر جزء of both maturation and storage
+
+640
+00:54:27,230 --> 00:54:31,660
+pool, maturation يعني في الـ bone marrow والـ storage
+
+641
+00:54:31,660 --> 00:54:35,680
+pool أيضا جزء منها في الـ bone marrow وجزء آخر
+
+642
+00:54:35,680 --> 00:54:37,480
+نجيه في الـ peripheral blood زي ما عندنا حاجة
+
+643
+00:54:37,480 --> 00:54:43,520
+نشتغلها مثل حوالي 40% الـ Brazil ده almost mature
+
+644
+00:54:43,520 --> 00:54:48,400
+يعني تقريبا كل وظائف الـ mature form of neutrophil
+
+645
+00:54:48,400 --> 00:54:52,660
+موجودة عندها في motility يعني في chemotaxis في
+
+646
+00:54:52,660 --> 00:54:58,200
+adhesion وchemotaxis ثم في phagocytic ability الـ
+
+647
+00:54:58,200 --> 00:55:02,620
+band form begins to produce tertiary granules في
+
+648
+00:55:02,620 --> 00:55:08,280
+هذه المرحلة بتبدأ تزهر تتزهر تتزهر تتزهر تتزهر
+
+649
+00:55:08,280 --> 00:55:13,740
+تتزهر تتزهر تتزهر تتزهر تتزهر تتزهر تتزهر
+
+650
+00:55:17,830 --> 00:55:22,670
+والـ membrane maturity shows change in skeleton
+
+651
+00:55:22,670 --> 00:55:27,410
+تبدأ تتغير اللي هو الـ membrane تبعها كمان surface
+
+652
+00:55:27,410 --> 00:55:33,370
+charge موجود وفي سيرة الريسيبتل بتظهر عليها بس تخش
+
+653
+00:55:33,370 --> 00:55:36,850
+على الـ peripheral blood بتشكل حوالي 6% من الـ
+
+654
+00:55:36,850 --> 00:55:41,710
+circulating white blood cells وحجمها لا تتجاوز الـ 10 لـ 15
+
+655
+00:55:41,710 --> 00:55:46,440
+micron in diameter وموجودة في الـ marginating
+
+656
+00:55:46,440 --> 00:55:55,600
+والـ circulating pool وبعدين هنشوفها mature form بتبدأ
+
+657
+00:55:55,600 --> 00:56:01,740
+الخلية أو الـ nucleus فيها indentation وuntil
+
+658
+00:56:01,740 --> 00:56:04,280
+a thin strand of membrane
+
+659
+00:56:10,160 --> 00:56:15,460
+اللي بتكون في النهاية وصلات لـ segments في داخل
+
+660
+00:56:15,460 --> 00:56:19,740
+الخلية يعني بتبدأ الـ nucleus تتحول إلى segments
+
+661
+00:56:19,740 --> 00:56:24,400
+موصولة بـ filaments السبب في ذلك أنه في continuous
+
+662
+00:56:24,400 --> 00:56:30,420
+indentation للـ nucleus وهذه خطوة من خطوات النضوج
+
+663
+00:56:30,420 --> 00:56:33,040
+عشان هيك الخلية في النهاية بيصير في multi-
+
+664
+00:56:33,040 --> 00:56:38,440
+segmented مظبوط وبيسموها poly يعني متعددة مورفل
+
+665
+00:56:38,440 --> 00:56:46,660
+نيوكليار بمعنى متعددة الأشكال many shaped nucleus و
+
+666
+00:56:46,660 --> 00:56:51,740
+بيسموها PMN cell is completely functional في هذه
+
+667
+00:56:51,740 --> 00:56:58,700
+المرحلة وب spend time in the storage pool of the
+
+668
+00:56:58,700 --> 00:57:02,680
+bone marrow as well as the marginating and
+
+669
+00:57:02,680 --> 00:57:06,520
+circulating pool اللي عندنا هنشوفه تشكل خمسين
+
+670
+00:57:06,520 --> 00:57:11,470
+لسبعين في الميه من circulating white blood cells بتقعد
+
+671
+00:57:11,470 --> 00:57:16,910
+وظيفة
+
+672
+00:57:16,910 --> 00:57:20,770
+الأساسية phagocytosis and pinocytosis بتعرف الفرق
+
+673
+00:57:20,770 --> 00:57:26,530
+بين التانين phagocytosis يعني بلع أكل ماشي بينما
+
+674
+00:57:26,530 --> 00:57:33,670
+الـ pinocytosis يعني شرب ماشي pino يعني تشرب أو
+
+675
+00:57:33,670 --> 00:57:37,270
+المادة المبلوعة بتكون سائلة بينما هناك المادة اللي
+
+676
+00:57:37,270 --> 00:57:43,310
+مبلوعة بتكون صلبة يعني phagocytosis involves large
+
+677
+00:57:43,310 --> 00:57:47,570
+material and can be observed with light
+
+678
+00:57:47,570 --> 00:57:51,930
+microscopy وإنما الـ pinocytosis involves small
+
+679
+00:57:51,930 --> 00:57:55,690
+material بالبنبغوسي الليكويد واللي بنشوفها
+
+680
+00:57:55,690 --> 00:58:02,050
+بالإلكترو مايكروسكوب الواضحتين هدول بيصيروا in
+
+681
+00:58:02,050 --> 00:58:07,170
+circulation وblood stream ينذفتشوا طيب خلينا نشوف
+
+682
+00:58:07,170 --> 00:58:11,130
+الكائنة تكسب نياترافيل وأن المراحل اللي بتمر فيها
+
+683
+00:58:11,130 --> 00:58:14,950
+ده هي من pluripotent stem cell تنتقل إلى مرحلة
+
+684
+00:58:14,950 --> 00:58:19,740
+ثانية هي progenitor cell ثم morphologically
+
+685
+00:58:19,740 --> 00:58:24,400
+recognizable cell دي بدنا إيهاش انعرفها سنة نقول
+
+686
+00:58:24,400 --> 00:58:28,120
+myeloblast يبرون myelocyte ثم myelocyte ثم
+
+687
+00:58:28,120 --> 00:58:32,420
+metamyelocyte وband وsegment العملية هذه بتاخد
+
+688
+00:58:32,420 --> 00:58:36,220
+لغاية الآن من ستة لعشر أيام بعدين بتطلع على الـ
+
+689
+00:58:36,220 --> 00:58:38,400
+peripheral circulation في الـ peripheral
+
+690
+00:58:38,400 --> 00:58:43,660
+circulation في عندنا two pools واحدة circulating
+
+691
+00:58:43,660 --> 00:58:46,760
+بمعنى ان white blood cell is circulating وdim
+
+692
+00:58:46,760 --> 00:58:51,490
+blood والتانية marginating بتكون الخلايا اللي هي
+
+693
+00:58:51,490 --> 00:58:55,450
+النيوتروفيل اللي ملزقة في جدار الوعاء الدموي بيسموها
+
+694
+00:58:55,450 --> 00:59:03,630
+marginating pool والتمتين بيحتووا على عدد متساوي
+
+695
+00:59:03,630 --> 00:59:09,370
+من الخلايا وزي ما أنتم شايفين السهم طالع نازل في
+
+696
+00:59:09,370 --> 00:59:14,150
+continuous exchange between marginating وbetween
+
+697
+00:59:14,150 --> 00:59:20,950
+circulating وإنّه احنا لما بنعد الـ white blood cells بنعد
+
+698
+00:59:20,950 --> 00:59:24,710
+نصف الـ white blood cells اللي هي الـ circulating white
+
+699
+00:59:24,710 --> 00:59:30,670
+blood cells تبقى الخلية في الـ peripheral blood من 6 لـ
+
+700
+00:59:30,670 --> 00:59:37,080
+10 دقائق إذا استدعيناها لـ infection عشان تعمل عملية 
+
+701
+00:59:37,080 --> 00:59:41,540
+قتل للميكروب phagocytosis فده هي راحت ما
+
+702
+00:59:41,540 --> 00:59:46,360
+استدعيناهاش بتموت بعد ما تنتهي العشرة بمعنى إذا 
+
+703
+00:59:46,360 --> 00:59:50,920
+مافيش antigenات ال life span تبعتها بتنتهي ولاحظوا
+
+704
+00:59:50,920 --> 00:59:55,780
+حاجة اللي هو ال regulating factors زي ما أنتو 
+
+705
+00:59:55,780 --> 00:59:59,820
+شايفين ال cytokine اللي فوق في مراحل معينة أدائية
+
+706
+00:59:59,820 --> 01:00:04,460
+المبكرة جدا stem cell factor أن الكو بيشتغل على ال
+
+707
+01:00:04,460 --> 01:00:09,380
+myeloblast فقط بيشاركوا في ذلك الآية التلاتة ثم
+
+708
+01:00:09,380 --> 01:00:14,580
+بيجي ال GMCSF بيشتغل على كل المراحل مين بيشاركوا
+
+709
+01:00:14,580 --> 01:00:19,960
+GCSF برضه بيشتغل على ايش على كل المراحل وهذا ما
+
+710
+01:00:19,960 --> 01:00:24,330
+يسمى بالkinetic of اللي هو Neutrophil أو
+
+711
+01:00:24,330 --> 01:00:28,230
+Gramminocytes نوع
+
+712
+01:00:28,230 --> 01:00:31,330
+آخر من الخلايا وهو الـ monocytes اللي بدها تنتقل
+
+713
+01:00:31,330 --> 01:00:36,470
+إلى أو تتحول إلى ال macrophage monocyte macrophage
+
+714
+01:00:36,470 --> 01:00:43,350
+ال mature from monoblast to promonocyte بعد هي
+
+715
+01:00:43,350 --> 01:00:48,250
+بتروح على ال blood as monocyte ثم بعد ذلك بتهاجر
+
+716
+01:00:48,250 --> 01:00:54,490
+إلى ال tissue as إما free يعني متحركة or fixed
+
+717
+01:00:54,490 --> 01:00:59,250
+macrophage لكن mechanism of commitment لغاية الآن
+
+718
+01:00:59,250 --> 01:01:05,410
+احنا مابنعرفش كيف بيتم عملية اختيار هذا الخط من 
+
+719
+01:01:05,410 --> 01:01:10,730
+الإنتاج granular content vary considerably with
+
+720
+01:01:10,730 --> 01:01:15,680
+more than 50 secretory compounds having been
+
+721
+01:01:15,680 --> 01:01:23,140
+identified يعني في أكتر من خمسين نوع من المركبات
+
+722
+01:01:23,140 --> 01:01:28,830
+موجودة في ال granules تبعتها بولي مورف بريفرال بلد
+
+723
+01:01:28,830 --> 01:01:34,070
+مونوسايت تشكل أشكال مختلفة تتشكل أشكال مختلفة وده
+
+724
+01:01:34,070 --> 01:01:37,890
+وضع طبيعي لإن الخلية لازالت immature يعني هي
+
+725
+01:01:37,890 --> 01:01:40,810
+الخلية الوحيدة اللي بتنزل من البرمارو على البرفرال
+
+726
+01:01:40,810 --> 01:01:44,830
+بلد as immature form بعد ذلك بتتقلتش و هناك بصلة
+
+727
+01:01:44,830 --> 01:01:51,370
+maturation و بتتحول إلى ال macrophage مونوسايت ال
+
+728
+01:01:51,370 --> 01:01:57,970
+nucleus is indented نطوية or curved يعني في انبعاج
+
+729
+01:01:57,970 --> 01:02:03,350
+فيها or cured و ال chromatin that is lazy و ال
+
+730
+01:02:03,350 --> 01:02:09,510
+small clumps lazy يعني ..يعني homogeneous في شوية
+
+731
+01:02:09,510 --> 01:02:13,730
+تكتلات فيها typically the largest cell هي أكبر
+
+732
+01:02:13,730 --> 01:02:16,350
+الخلايا في ال peripheral blood و برضه مرجى تانية
+
+733
+01:02:16,350 --> 01:02:22,870
+أكدلكوا لإنها immature عشان هي كبيرة السيتوبلازم
+
+734
+01:02:22,870 --> 01:02:26,690
+مليئ بالميزة من الميزة المتوسطة التي تجعلها تبدو
+
+735
+01:02:26,690 --> 01:02:31,290
+مظلمة، مظلمة يعني زي الغيمة، السيتوبلازم بيكون
+
+736
+01:02:31,290 --> 01:02:38,190
+سيتوبلازمية غشائية ممكن تكون عادية، سودو بود،
+
+737
+01:02:38,190 --> 01:02:43,330
+وفاكوستيكيكيكيكيكيكيكيكيكيكيكيكيكيكي
+
+738
+01:02:44,710 --> 01:02:46,970
+وهي المراحل بتمر فيها من الـ monoblast
+
+739
+01:02:46,970 --> 01:02:52,990
+لبرومونوسايتس وين موجود في ال bone marrow ثم بتنزل
+
+740
+01:02:52,990 --> 01:02:56,930
+على ال peripheral blood as monocyte و بتقعد من 3 ل
+
+741
+01:02:56,930 --> 01:03:00,190
+8 ساعات في ال peripheral blood ثم بتنتقل على ال
+
+742
+01:03:00,190 --> 01:03:04,230
+tissue كإما mature or macrophage ثم بيصير mature
+
+743
+01:03:04,230 --> 01:03:09,410
+or macrophage و قلتلكوا في نوعين إما free or fixed
+
+744
+01:03:12,550 --> 01:03:17,790
+آخر هذه الخلايا هي الـ lymphocytes the only human
+
+745
+01:03:17,790 --> 01:03:20,250
+white blood cell whose site of development is not
+
+746
+01:03:20,250 --> 01:03:23,950
+just bone marrow هو هي الخلية الوحيدة اللي ندوجها
+
+747
+01:03:23,950 --> 01:03:29,010
+أو نشوقة sorry ندوجها لا يتم في ال bone marrow
+
+748
+01:03:29,010 --> 01:03:38,970
+لحاله لكن tissue referred to as primary and
+
+749
+01:03:38,970 --> 01:03:42,960
+secondary lymphoid organs الآن هنشوفه إن ال primary
+
+750
+01:03:42,960 --> 01:03:46,120
+lymphoid organs كلنا بنعرف إن ال primary lymphoid
+
+751
+01:03:46,120 --> 01:03:50,880
+organs في الإنسان هي ال bone marrow و ال thymus
+
+752
+01:03:50,880 --> 01:03:55,300
+الخلية طبعا فيه أن other secondary طبعا فيه أن ال
+
+753
+01:03:55,300 --> 01:03:58,760
+lymph nodes و ال spleen و ال kiss patches و
+
+754
+01:03:58,760 --> 01:04:02,980
+الwaldemeier ring هذا خدته كله في ال anatomy كله
+
+755
+01:04:02,980 --> 01:04:07,190
+هذا عبارة عن secondary lymphoid organs الخلية ال
+
+756
+01:04:07,190 --> 01:04:12,030
+lymphocyte بالمناسبة بتنشأ في ال bone marrow ثم في
+
+757
+01:04:12,030 --> 01:04:15,530
+مرحلة مبكرة جدا تنتقل من ال bone marrow و تروح
+
+758
+01:04:15,530 --> 01:04:21,230
+وين؟ على ال thymus أي نوع ال T cell ال B ليش بيصير
+
+759
+01:04:21,230 --> 01:04:24,890
+فيه؟ بيضل في ال bone marrow و يندرج في ال bone
+
+760
+01:04:24,890 --> 01:04:27,490
+marrow و يندرج في ايش؟ في ال bone marrow طبعا
+
+761
+01:04:27,490 --> 01:04:30,310
+التنتين متى ما ندجوا و طلعوا واحدة من البودمار و
+
+762
+01:04:30,310 --> 01:04:32,930
+واحدة من الثايمس بيروحوا على ال blood و من ال
+
+763
+01:04:32,930 --> 01:04:35,550
+blood بيروحوا على ال secondary lymphoid organs و
+
+764
+01:04:35,550 --> 01:04:40,690
+هناك بيحاربوا اللي هو ال antigen لأن وظيفتهم
+
+765
+01:04:40,690 --> 01:04:45,790
+مناعية ال lymphocytes circulate through the blood
+
+766
+01:04:45,790 --> 01:04:49,330
+و ال both peripheral blood ده كله توانة حكيتها لكم
+
+767
+01:04:49,330 --> 01:04:54,230
+إياها الخلايا ممكن تكون short lived or long lived
+
+768
+01:04:56,120 --> 01:04:59,460
+ممكن يكون عمرها الزمن يختلف، يتباين عمرها الزمن
+
+769
+01:04:59,460 --> 01:05:03,320
+الزمني، في خلايا بتفرزلي انتيبادي زي الـ B
+
+770
+01:05:03,320 --> 01:05:07,140
+-Lymphocyte وفي خلايا بتشتلأ الـ cell mediated من
+
+771
+01:05:07,140 --> 01:05:12,920
+خلال الريسبتور المعينة الـ pluripotential stem
+
+772
+01:05:12,920 --> 01:05:19,440
+cell، resultant stem cell for lymphoid cell، هي
+
+773
+01:05:19,440 --> 01:05:23,440
+colony forming unit لينفويد من المراحل، و ال colony
+
+774
+01:05:23,440 --> 01:05:26,020
+forming unit mature in several environments،
+
+775
+01:05:26,590 --> 01:05:34,870
+والتنالكو بيصير لها ندوج في ال primary للانفوض
+
+776
+01:05:34,870 --> 01:05:39,110
+organs وفي هذه المرحلة بيسموها antigen independent
+
+777
+01:05:39,110 --> 01:05:43,430
+يعني في غياب وجود ال antigen بيصير فيه ندوج لهذه
+
+778
+01:05:43,430 --> 01:05:50,810
+الخلايا تنزل بعدين على البرفرال بلد ونسبتها
+
+779
+01:05:50,810 --> 01:05:55,630
+بتختلف باختلاف العمرفي الأطفال على سبيل المثال في
+
+780
+01:05:55,630 --> 01:06:06,490
+عمر أربع سنوات الانفصاد بتكون عالية و بتعتبر the
+
+781
+01:06:06,490 --> 01:06:10,050
+second most common white species في البرفربلب
+
+782
+01:06:10,050 --> 01:06:16,840
+بتشكل من 20 ل 40% من ال white species عشرين لخمسة
+
+783
+01:06:16,840 --> 01:06:20,740
+و تلاتين فمية من هذه الخلايا هي B
+
+784
+01:06:20,740 --> 01:06:25,160
+-lymphocyte والباقي هو T-lymphocytes المراحل اللي
+
+785
+01:06:25,160 --> 01:06:30,300
+بتمر فيها lymphoblasts to pro-lymphocytes
+
+786
+01:06:30,300 --> 01:06:35,640
+lymphoblast أصغرهم من عشر لتمنتاش round to oval
+
+787
+01:06:35,640 --> 01:06:39,920
+loose chromatin with one or more active nuclei
+
+788
+01:06:41,650 --> 01:06:47,730
+scanty يعني قليل الـ cytoplasm و الـ pro
+
+789
+01:06:47,730 --> 01:06:51,710
+lymphocytes difficult to distinguish عن ال
+
+790
+01:06:51,710 --> 01:06:59,710
+lymphocyte subtle changes يعني اختلافات صعبة more
+
+791
+01:06:59,710 --> 01:07:04,170
+clumped chromatins lessening nuclear prominence
+
+792
+01:07:04,170 --> 01:07:09,460
+change in thickness of the nuclei وهي ال
+
+793
+01:07:09,460 --> 01:07:13,320
+lymphopoiesis هدا هي في ال bone marrow بتندج كل
+
+794
+01:07:13,320 --> 01:07:18,500
+الخلايا مع other cells ثم بتديني stem cell
+
+795
+01:07:18,500 --> 01:07:25,160
+lymphoid ماشي و هاد ال stem cell جزء منها بصير B
+
+796
+01:07:25,160 --> 01:07:30,060
+cell و جزء منها بصير T cell ال B cell برو بيه
+
+797
+01:07:30,060 --> 01:07:34,420
+بيندج ل بري بيه و بعدين بتطلع كأي mature بيه ثم
+
+798
+01:07:34,420 --> 01:07:39,470
+mature على البرفرالبلاد بينما البروتي بتروح الـ
+
+799
+01:07:39,470 --> 01:07:43,990
+thymus و هناك بيصير في عملية مضوج إليها و بتطلع
+
+800
+01:07:43,990 --> 01:07:48,770
+بعد هيك اما CD4 و اما CD8 البيسل تديني كل انواع
+
+801
+01:07:48,770 --> 01:07:52,810
+الانتيبادية دهية بينما التيسل فيه انه different
+
+802
+01:07:52,810 --> 01:07:58,090
+types of ash أو تيسل آخر هذه الأنواع هو
+
+803
+01:07:58,090 --> 01:08:05,060
+thrombopoiesis يعني ايش يعني إنتاج لـ platelet كيف
+
+804
+01:08:05,060 --> 01:08:11,460
+بتتم؟ قالوا هذه اختلاف كل عن الخلايا الأخرى، ماشي
+
+805
+01:08:11,460 --> 01:08:14,880
+أولا الـplatelet وظيفتها الأساسية في الـprimary
+
+806
+01:08:14,880 --> 01:08:17,720
+hemostasis يعني التلتة العبدالجبير في عملية التجلب
+
+807
+01:08:17,720 --> 01:08:22,320
+ال life span تبعتها المنتج يعني من سبعة لعشر أيام
+
+808
+01:08:24,050 --> 01:08:29,170
+وغالبا بتنتج as if fragmented of cytoplasm من مين؟
+
+809
+01:08:29,170 --> 01:08:33,030
+من ال megakaryocytes يعني عبارة عن نطوئات عبارة عن
+
+810
+01:08:33,030 --> 01:08:39,670
+fragments من ال megakaryocyte cytoplasm و العملية
+
+811
+01:08:39,670 --> 01:08:46,550
+بتتم بطريقة مختلفة من الندوش قالوا اسموها
+
+812
+01:08:46,550 --> 01:08:50,830
+endomyotic replication process ايش يعني endomyotic
+
+813
+01:08:50,830 --> 01:08:55,190
+replication؟ أن الندوش داخلي ماشي اللي مصير قالوا
+
+814
+01:08:55,190 --> 01:09:02,070
+بتتك .. بتزيد مصير في replication لل DNA و بتبدأ
+
+815
+01:09:02,070 --> 01:09:13,280
+ال .. الخلية تكبر ماشي و ال cytoplasm يبدأ يكبرو
+
+816
+01:09:13,280 --> 01:09:19,380
+هدا هي زي ما أنتو شايفين بدت صغيرة ثم كبرت ماشي و
+
+817
+01:09:19,380 --> 01:09:23,420
+زي ما أنتو شايفين ال DNA بدأ بواحدة ثم صارله
+
+818
+01:09:23,420 --> 01:09:28,480
+replication ماشي لكن بيصيرش انقسام للخلية بتضل
+
+819
+01:09:28,480 --> 01:09:33,400
+الخلية تكبر و ت .. و تكبر و ت .. لغاية ما .. هدا
+
+820
+01:09:33,400 --> 01:09:37,460
+هي زي ما أنتو شايفين كبرت كتير تصل إلى مرحلة
+
+821
+01:09:37,460 --> 01:09:43,360
+بتنفجر هذه الخلية ويطلع منها مين؟ اللي هو
+
+822
+01:09:43,360 --> 01:09:47,260
+fragments of cytoplasm وهو اللي بنسميها
+
+823
+01:09:47,260 --> 01:09:52,780
+الـplatelet طبعا
+
+824
+01:09:52,780 --> 01:09:55,220
+الـplatelet بس تطلع الـperipheral blood طولتها
+
+825
+01:09:55,220 --> 01:09:58,340
+بيروح على الـspleen ويخزن في الـspleen as reserve
+
+826
+01:10:02,080 --> 01:10:05,020
+مين اللي مسؤول عنه؟ أولا هذه المراحل اللي بتمر
+
+827
+01:10:05,020 --> 01:10:08,800
+فيها هي stem cell ثم multipotent progenitor cell
+
+828
+01:10:08,800 --> 01:10:12,620
+ثم committed يعني التزمت megakaryocyte progenitor
+
+829
+01:10:12,620 --> 01:10:16,660
+cell ثم immature megakaryocyte ثم mature
+
+830
+01:10:16,660 --> 01:10:20,580
+megakaryocyte ومتى ما صارت mature بتنفجر و بتدنياش
+
+831
+01:10:20,580 --> 01:10:24,140
+ال platelet زي ما تشهد هي المراحل المختلفة اللي
+
+832
+01:10:24,140 --> 01:10:28,440
+بتمر فيها و هذه عبارة عن ال cytokine أو ال
+
+833
+01:10:28,440 --> 01:10:32,300
+regulators لكل مرحلة من المراحل زي ما تلاحظوا
+
+834
+01:10:32,300 --> 01:10:39,600
+thrombobiotin موجود في كل مرحلة من المراحل ايش دور
+
+835
+01:10:39,600 --> 01:10:44,560
+ال IL-1؟ قالوا ال IL-1 هذا cytokine مميز بيلعب دور
+
+836
+01:10:44,560 --> 01:10:50,900
+كبير في كل إنتاج معظم خلايا الجسم الإنسان، معظم
+
+837
+01:10:50,900 --> 01:10:55,040
+خلايا الجسم الإنسان، ماشي؟ فهي أشتغل دوة IL-1 من
+
+838
+01:10:55,040 --> 01:11:01,410
+.. ماشي؟داني telephocyte في وجودها يلوان، داني
+
+839
+01:11:01,410 --> 01:11:07,450
+encysal، داني neutrophil، داني muscle cell، داني
+
+840
+01:11:07,450 --> 01:11:12,330
+brain cell، وهكذا عشان هيك بيسموه the father of 
+
+841
+01:11:12,330 --> 01:11:19,770
+cytokine طيب الـsummary أرجو أن تكونوا يعني
+
+842
+01:11:19,770 --> 01:11:24,600
+تابعتوا معايا متابعة جيدة وخلّينا نعمل تلخيص لعيش
+
+843
+01:11:24,600 --> 01:11:28,460
+لهذه المخادرة normal hemopause is necessary for
+
+844
+01:11:28,460 --> 01:11:33,000
+survival طبيعي جدا ضروري for survival وإلا بدون
+
+845
+01:11:33,000 --> 01:11:37,060
+خلايا احنا ما بيصير فيه حياة it's under the
+
+846
+01:11:37,060 --> 01:11:39,980
+control of multiple factors شوفنا العوامل المختلفة
+
+847
+01:11:39,980 --> 01:11:44,120
+اللي بتعيش بتتحكم في هذه العملية normal bone
+
+848
+01:11:44,120 --> 01:11:46,980
+marrow environment is necessary للـ normal bone
+
+849
+01:11:46,980 --> 01:11:51,900
+.. للـ micro environment خاصة فيها ولا لأ؟ ثم
+
+850
+01:11:51,900 --> 01:11:56,100
+Decrease production results in cytopenia ما فيش
+
+851
+01:11:56,100 --> 01:11:59,620
+إنتاج بيصير فيه قلة فيه إيش فيه عدد الخلايا
+
+852
+01:11:59,620 --> 01:12:05,740
+بيسموها cyto يعني خلية وpenia قلة ماشي cytopenia
+
+853
+01:12:05,740 --> 01:12:14,180
+وهي الـhemopoietic ماشي characteristic feature فقط
+
+854
+01:12:14,180 --> 01:12:19,560
+تلاحظ الاختلافات ماشي المختلفة
+
+855
+01:12:23,880 --> 01:12:27,700
+بتكون غير ناضجة، بتكون كبيرة، ولما بتنضج، بتصغر.
+
+856
+01:12:29,000 --> 01:12:32,100
+لما بتكون غير ناضجة، بيكون الـcytoplasm كبير و
+
+857
+01:12:32,100 --> 01:12:37,400
+أزرق، لما بيتنضج، بيقل، وفي نفس الوقت بيتحول لونه 
+
+858
+01:12:37,400 --> 01:12:41,980
+إلى لون بنكرا، عسم الـMetal في العرب السيطر. ماشي؟
+
+859
+01:12:41,980 --> 01:12:45,920
+مرت في أكثر من مرحلة، مراحل كثيرة. في مراحل مبكرة،
+
+860
+01:12:45,920 --> 01:12:50,080
+بيكون فيه الـnucleus و الـnucleoli في مراحل مختلفة،
+
+861
+01:12:50,080 --> 01:12:53,500
+هي راحت الـNucleus من أصله بالنسبة للـRBC وها كذا
+
+862
+01:12:53,500 --> 01:12:57,500
+كل ما نضجت الخلية اختلفت في الـsize اختلفت في
+
+863
+01:12:57,500 --> 01:13:01,520
+الـnucleus shape اختلفت في الـcytoplasm content
+
+864
+01:13:01,520 --> 01:13:08,340
+and shape ودوم الاختلافات one by one هي كانت large
+
+865
+01:13:08,340 --> 01:13:13,260
+وصارت صغيرة الـnucleoli كانت موجودة بطلت
+
+866
+01:13:13,260 --> 01:13:16,200
+الـnucleus سورياني
+
+867
+01:13:20,100 --> 01:13:25,620
+Disappear. Cytoplasm thinning كان دي بفلوسار اللي
+
+868
+01:13:25,620 --> 01:13:31,760
+هو various color حسب نوع الخلية. Formation of
+
+869
+01:13:31,760 --> 01:13:35,260
+granules بيكون أول شي ليسي ثم بيصير فيه condensed.
+
+870
+01:13:36,400 --> 01:13:41,500
+Mitosis بيكون عالي وبدأش الـmitotic activity يتقل.
+
+871
+01:13:44,270 --> 01:13:48,390
+monophyletic theory of cell formation هذه النظريات
+
+872
+01:13:48,390 --> 01:13:53,570
+اللي حطوها لعملية الـhemopoiesis قالوا فيها انها
+
+873
+01:13:53,570 --> 01:14:00,710
+monophyletic وضعيفلتك ثم اللي هو tri او poly
+
+874
+01:14:00,710 --> 01:14:05,310
+monophyletic theory إيش بتقول؟ بتقول ان كل الخلايا
+
+875
+01:14:05,310 --> 01:14:09,870
+هذه أساسها خلية واحدة وهي الـstem cell طبعا لما
+
+876
+01:14:09,870 --> 01:14:13,720
+بتحكي على ضعيفلتك بتحكي على خليتين كل الخلايا
+
+877
+01:14:13,720 --> 01:14:20,560
+أساسهم خاليتين ماشي لكن أكثر النظريات شيوعا و
+
+878
+01:14:20,560 --> 01:14:24,480
+قبولا هي هذه النظرية وهي الـmonophoretic theory أن
+
+879
+01:14:24,480 --> 01:14:28,160
+كل الخلايا أساسها خلية واحدة هي الاستمثال زي ما
+
+880
+01:14:28,160 --> 01:14:32,220
+شرحنا تدينا خالتين monomyloid وليكفويد وكل واحدة
+
+881
+01:14:32,220 --> 01:14:39,080
+بتدينا خلايا مختلفة حسب النوع أتمنى لكم إن شاء
+
+882
+01:14:39,080 --> 01:14:45,570
+اللهال .. أن تكونوا قد استمتعتوا في هذه المحاضرة و
+
+883
+01:14:45,570 --> 01:14:51,350
+أن تكونوا تابعتوني واستوعبتم المحاضرة المحاضرة
+
+884
+01:14:51,350 --> 01:14:58,770
+سهلة فقد تحتاج إلى المراجعة والمراجعة الفورية ما
+
+885
+01:14:58,770 --> 01:15:01,610
+بنفع نسيبها فترة معينة وشكرا
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..e968f355a7a622c8bc820160cd3cae0face82bef
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3055, "start": 3.19, "end": 30.55, "text": "باسم الله الرحمن الرحيم سابق وحكينا ان ال hemopoiesis هي عملية development and production of cells بتتم فيها تطور وندوش هذه الخلايا وقولنا عشان تتم هذه العملية نحتاج إلى تلت عوامل أساسية العامل الأولاني هو وجود ال stem cell", "tokens": [3555, 32277, 2304, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 8608, 16758, 4587, 4032, 5016, 4117, 1829, 8315, 16472, 2423, 8636, 404, 78, 530, 271, 39896, 6225, 42213, 10632, 3250, 293, 4265, 295, 5438, 39894, 39237, 8978, 11296, 6055, 9566, 13063, 4032, 1863, 3215, 2407, 8592, 29538, 33962, 15040, 25528, 4032, 39648, 8315, 6225, 8592, 7649, 6055, 39237, 29538, 18863, 42213, 10632, 8717, 33753, 26108, 30731, 6055, 1211, 2655, 6225, 2407, 10943, 1211, 5551, 3794, 32277, 10632, 18863, 10943, 1211, 16247, 12610, 7649, 1829, 31439, 49610, 23328, 2423, 12312, 2815], "avg_logprob": -0.21892170820917403, "compression_ratio": 1.5982142857142858, "no_speech_prob": 4.231929779052734e-06, "words": [{"start": 3.19, "end": 3.55, "word": "باسم", "probability": 0.7301432291666666}, {"start": 3.55, "end": 3.75, "word": " الله", "probability": 0.78515625}, {"start": 3.75, "end": 4.13, "word": " الرحمن", "probability": 0.9345703125}, {"start": 4.13, "end": 4.67, "word": " الرحيم", "probability": 0.9900716145833334}, {"start": 4.67, "end": 6.43, "word": " سابق", "probability": 0.75146484375}, {"start": 6.43, "end": 7.11, "word": " وحكينا", "probability": 0.747509765625}, {"start": 7.11, "end": 8.57, "word": " ان", "probability": 0.57568359375}, {"start": 8.57, "end": 9.15, "word": " ال", "probability": 0.7822265625}, {"start": 9.15, "end": 10.11, "word": " hemopoiesis", "probability": 0.6904296875}, {"start": 10.11, "end": 10.35, "word": " هي", "probability": 0.904296875}, {"start": 10.35, "end": 11.37, "word": " عملية", "probability": 0.95654296875}, {"start": 11.37, "end": 12.05, "word": " development", "probability": 0.466796875}, {"start": 12.05, "end": 12.57, "word": " and", "probability": 0.5791015625}, {"start": 12.57, "end": 13.07, "word": " production", "probability": 0.95458984375}, {"start": 13.07, "end": 13.51, "word": " of", "probability": 0.94091796875}, {"start": 13.51, "end": 14.45, "word": " cells", "probability": 0.84228515625}, {"start": 14.45, "end": 15.71, "word": " بتتم", "probability": 0.3826904296875}, {"start": 15.71, "end": 16.33, "word": " فيها", "probability": 0.970458984375}, {"start": 16.33, "end": 19.45, "word": " تطور", "probability": 0.9495442708333334}, {"start": 19.45, "end": 20.71, "word": " وندوش", "probability": 0.78349609375}, {"start": 20.71, "end": 21.05, "word": " هذه", "probability": 0.95068359375}, {"start": 21.05, "end": 21.59, "word": " الخلايا", "probability": 0.8966471354166666}, {"start": 21.59, "end": 23.09, "word": " وقولنا", "probability": 0.615966796875}, {"start": 23.09, "end": 23.53, "word": " عشان", "probability": 0.89599609375}, {"start": 23.53, "end": 23.91, "word": " تتم", "probability": 0.749267578125}, {"start": 23.91, "end": 24.19, "word": " هذه", "probability": 0.93896484375}, {"start": 24.19, "end": 24.71, "word": " العملية", "probability": 0.9695638020833334}, {"start": 24.71, "end": 25.23, "word": " نحتاج", "probability": 0.9319661458333334}, {"start": 25.23, "end": 25.43, "word": " إلى", "probability": 0.55908203125}, {"start": 25.43, "end": 25.79, "word": " تلت", "probability": 0.84619140625}, {"start": 25.79, "end": 26.23, "word": " عوامل", "probability": 0.9805908203125}, {"start": 26.23, "end": 26.87, "word": " أساسية", "probability": 0.9324951171875}, {"start": 26.87, "end": 27.91, "word": " العامل", "probability": 0.9230143229166666}, {"start": 27.91, "end": 28.67, "word": " الأولاني", "probability": 0.9302978515625}, {"start": 28.67, "end": 29.43, "word": " هو", "probability": 0.98486328125}, {"start": 29.43, "end": 29.81, "word": " وجود", "probability": 0.95458984375}, {"start": 29.81, "end": 29.95, "word": " ال", "probability": 0.4794921875}, {"start": 29.95, "end": 30.19, "word": " stem", "probability": 0.66015625}, {"start": 30.19, "end": 30.55, "word": " cell", "probability": 0.8896484375}], "temperature": 1.0}, {"id": 2, "seek": 6135, "start": 31.69, "end": 61.35, "text": "و العامل التاني هو ال hemopoietic micro environment و العامل التالت ال growth factor وهذه عملية عملية بناء بتشبه أي عملية بناء يعني انا دايما بشبهها ببناء مسجد او بناء منزل عشان تبني المنزل بدك تلت شغلات بدك الأرض اللى بدك تبني عليها ثم مواد البناء ثم العمال اللى بدهم يبنوا البناء", "tokens": [2407, 18863, 10943, 1211, 16712, 7649, 1829, 31439, 2423, 8636, 404, 78, 1684, 299, 4532, 2823, 4032, 18863, 10943, 1211, 16712, 6027, 2655, 2423, 4599, 5952, 37037, 24192, 6225, 42213, 10632, 6225, 42213, 10632, 44945, 16606, 39894, 8592, 3555, 3224, 36632, 6225, 42213, 10632, 44945, 16606, 37495, 22653, 1975, 8315, 11778, 47302, 15042, 4724, 8592, 3555, 3224, 11296, 4724, 3555, 1863, 16606, 47524, 7435, 3215, 1975, 2407, 44945, 16606, 9154, 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35.91, "end": 36.23, "word": " micro", "probability": 0.91015625}, {"start": 36.23, "end": 36.83, "word": " environment", "probability": 0.4892578125}, {"start": 36.83, "end": 37.11, "word": " و", "probability": 0.73388671875}, {"start": 37.11, "end": 37.45, "word": " العامل", "probability": 0.978515625}, {"start": 37.45, "end": 37.95, "word": " التالت", "probability": 0.9241536458333334}, {"start": 37.95, "end": 38.13, "word": " ال", "probability": 0.6318359375}, {"start": 38.13, "end": 38.39, "word": " growth", "probability": 0.61572265625}, {"start": 38.39, "end": 38.91, "word": " factor", "probability": 0.89501953125}, {"start": 38.91, "end": 39.91, "word": " وهذه", "probability": 0.754150390625}, {"start": 39.91, "end": 40.57, "word": " عملية", "probability": 0.95556640625}, {"start": 40.57, "end": 41.63, "word": " عملية", "probability": 0.939453125}, {"start": 41.63, "end": 42.13, "word": " بناء", "probability": 0.969970703125}, {"start": 42.13, "end": 42.77, "word": " بتشبه", "probability": 0.916748046875}, {"start": 42.77, "end": 42.95, "word": " أي", "probability": 0.54736328125}, {"start": 42.95, "end": 43.35, "word": " عملية", "probability": 0.9845377604166666}, {"start": 43.35, "end": 43.65, "word": " بناء", "probability": 0.96533203125}, {"start": 43.65, "end": 43.87, "word": " يعني", "probability": 0.871337890625}, {"start": 43.87, "end": 44.11, "word": " انا", "probability": 0.7149658203125}, {"start": 44.11, "end": 44.39, "word": " دايما", "probability": 0.8094889322916666}, {"start": 44.39, "end": 45.21, "word": " بشبهها", "probability": 0.9138671875}, {"start": 45.21, "end": 45.95, "word": " ببناء", "probability": 0.96728515625}, {"start": 45.95, "end": 46.59, "word": " مسجد", "probability": 0.9938151041666666}, {"start": 46.59, "end": 47.15, "word": " او", "probability": 0.955322265625}, {"start": 47.15, "end": 47.59, "word": " بناء", "probability": 0.9541015625}, {"start": 47.59, "end": 48.27, "word": " منزل", "probability": 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"end": 55.71, "word": " ثم", "probability": 0.986328125}, {"start": 55.71, "end": 56.23, "word": " مواد", "probability": 0.9578450520833334}, {"start": 56.23, "end": 56.91, "word": " البناء", "probability": 0.9278971354166666}, {"start": 56.91, "end": 58.03, "word": " ثم", "probability": 0.988037109375}, {"start": 58.03, "end": 60.01, "word": " العمال", "probability": 0.9744466145833334}, {"start": 60.01, "end": 60.27, "word": " اللى", "probability": 0.98974609375}, {"start": 60.27, "end": 60.61, "word": " بدهم", "probability": 0.9716796875}, {"start": 60.61, "end": 60.95, "word": " يبنوا", "probability": 0.9058837890625}, {"start": 60.95, "end": 61.35, "word": " البناء", "probability": 0.9479166666666666}], "temperature": 1.0}, {"id": 3, "seek": 9129, "start": 62.15, "end": 91.29, "text": "طبعا الأرض اللى بدنا نبنى عليها متمثلة هنا بال hemopoietic micro environment ثم المواد البناء متمثلة بال stem cell ثم العمال اللى هم ال hemopoietic growth factor وحكينا عن ال stem cell في الفيديو 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growth factors و بتزود الخلايا الغير نادجة اللي بدها تاندج ب growth factor و ب nutrient عشان تتطور نمرا اتنين ان الخلايا الغير نادجة على سطح ال receptors", "tokens": [3555, 3224, 24192, 33962, 15040, 25528, 39894, 5172, 2288, 11622, 2423, 4599, 6771, 4032, 39894, 11622, 23328, 33962, 15040, 25528, 6024, 118, 13546, 8717, 18513, 7435, 3660, 13672, 1829, 47525, 11296, 6055, 7649, 3215, 7435, 4724, 4599, 5952, 4032, 4724, 32694, 6225, 8592, 7649, 6055, 2655, 9566, 13063, 8717, 2304, 23557, 1975, 2655, 1863, 9957, 16472, 33962, 15040, 25528, 6024, 118, 13546, 8717, 18513, 7435, 3660, 15844, 8608, 9566, 5016, 2423, 34102], "avg_logprob": -0.18054366275055767, "compression_ratio": 1.6890243902439024, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 152.57, "end": 153.79, "word": "بهذه", "probability": 0.7413736979166666}, {"start": 153.79, "end": 154.45, "word": " الخلايا", "probability": 0.9586588541666666}, {"start": 154.45, "end": 157.93, "word": " بتفرز", "probability": 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"text": "ماشي cluster مجموعة differentiation مجموعة الخلايا اللي صار لها differentiation CD اختصار ليش cluster of differentiation ماشي وهدب يعني ان كل الخلايا في هذه المرحلة بتكون تحتوي على one marker اللي هو اعطوه رقم 34 هنبدأ نفهمه", "tokens": [2304, 33599, 1829, 13630, 3714, 7435, 2304, 2407, 27884, 38902, 3714, 7435, 2304, 2407, 27884, 33962, 15040, 25528, 13672, 1829, 20328, 9640, 5296, 11296, 38902, 6743, 1975, 46456, 9381, 9640, 32239, 8592, 13630, 295, 38902, 3714, 33599, 1829, 37037, 3215, 3555, 37495, 22653, 16472, 28242, 33962, 15040, 25528, 8978, 29538, 9673, 2288, 5016, 37977, 39894, 30544, 6055, 33753, 45865, 15844, 472, 15247, 13672, 1829, 31439, 1975, 3615, 9566, 2407, 3224, 12602, 4587, 2304, 12790, 8032, 1863, 44510, 10721, 8717, 5172, 16095, 3224], "avg_logprob": -0.20990210699747844, "compression_ratio": 1.625, "no_speech_prob": 1.1622905731201172e-05, "words": [{"start": 1049.39, "end": 1049.75, "word": "ماشي", "probability": 0.6442057291666666}, {"start": 1049.75, 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Ligand تبعه وهو الـ Receptor وهو الـ Ligand فببدأ يتنشط سلسلة من ال Transcriptional Factor اللي في النهاية بتزود لنا عملية ال Erythropoiesis", "tokens": [3224, 2407, 7251, 2655, 4117, 2407, 11703, 1863, 4032, 13546, 2655, 3555, 9566, 20666, 39184, 441, 328, 474, 6055, 3555, 3615, 3224, 37037, 2407, 2423, 39184, 1300, 1336, 284, 37037, 2407, 2423, 39184, 441, 328, 474, 6156, 3555, 44510, 10721, 7251, 2655, 1863, 8592, 9566, 8608, 1211, 3794, 37977, 9154, 2423, 6531, 12432, 304, 479, 15104, 13672, 1829, 8978, 28239, 11296, 10632, 39894, 11622, 23328, 5296, 8315, 6225, 42213, 10632, 2423, 462, 627, 14222, 78, 530, 271], "avg_logprob": -0.36217949902399993, "compression_ratio": 1.3806818181818181, "no_speech_prob": 2.8133392333984375e-05, "words": [{"start": 2818.11, "end": 2818.19, "word": "هو", "probability": 0.2406768798828125}, {"start": 2818.19, "end": 2818.91, "word": " يتكوّن", "probability": 0.5982259114583334}, {"start": 2818.91, "end": 2819.83, "word": " ويرتبط", "probability": 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Erythropoiesis", "probability": 0.8128255208333334}], "temperature": 1.0}, {"id": 109, "seek": 285082, "start": 2838.14, "end": 2850.82, "text": "هذا ما يخص الـ Erythropoiesis، الـ Granulopoiesis نفس الحكاية، بدها تديني اللي هو الـ Granulocyte وهي الإيزينوفيل و النيوتروفيل و البيزوفيل", "tokens": [3224, 15730, 19446, 7251, 9778, 9381, 2423, 39184, 462, 627, 14222, 78, 530, 271, 12399, 2423, 39184, 23554, 425, 404, 78, 530, 271, 8717, 36178, 21542, 4117, 995, 10632, 12399, 47525, 11296, 6055, 3215, 9957, 1829, 13672, 1829, 31439, 2423, 39184, 23554, 425, 31078, 975, 37037, 1829, 33688, 1829, 11622, 9957, 38688, 26895, 4032, 2423, 22653, 35473, 32887, 41185, 1211, 4032, 2423, 21292, 11622, 38688, 26895], "avg_logprob": -0.29244402985074625, "compression_ratio": 1.5422535211267605, "no_speech_prob": 0.0, "words": [{"start": 2838.14, "end": 2838.46, "word": "هذا", "probability": 0.90869140625}, {"start": 2838.46, "end": 2838.58, "word": " ما", "probability": 0.9482421875}, {"start": 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ايش من سابقتها Nuclear chromatin may be delicate or may slide clumping, nuclei begin to fade", "tokens": [6027, 39184, 1222, 338, 404, 15459, 4032, 29538, 39896, 25062, 995, 22488, 3660, 39894, 8592, 8848, 34105, 6156, 47432, 8978, 29538, 9673, 2288, 5016, 37977, 1975, 5016, 8315, 12174, 1211, 8315, 16472, 33962, 1211, 10632, 28242, 19446, 20328, 9640, 2655, 544, 14442, 28242, 19446, 8717, 11242, 7435, 2655, 28242, 19446, 30767, 17082, 43500, 42963, 16472, 3224, 8978, 29538, 9673, 2288, 5016, 37977, 9673, 2288, 5016, 37977, 29538, 1975, 4117, 26890, 9154, 1975, 1829, 8592, 9154, 8608, 16758, 38149, 11296, 42528, 16209, 22685, 815, 312, 21417, 420, 815, 4137, 596, 35313, 11, 49919, 1841, 281, 21626], "avg_logprob": -0.24886066559702158, "compression_ratio": 1.648068669527897, "no_speech_prob": 1.6689300537109375e-06, "words": [{"start": 3013.4499999999994, "end": 3014.2099999999996, "word": "الـ", "probability": 0.5782470703125}, {"start": 3014.2099999999996, "end": 3014.97, "word": " 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"probability": 0.937744140625}, {"start": 3153.81, "end": 3154.65, "word": " شكل", "probability": 0.74560546875}, {"start": 3154.65, "end": 3155.45, "word": " ال", "probability": 0.90380859375}, {"start": 3155.45, "end": 3155.87, "word": " pink", "probability": 0.67138671875}, {"start": 3155.87, "end": 3156.69, "word": " الزهري", "probability": 0.7449951171875}, {"start": 3156.69, "end": 3157.33, "word": " compounds", "probability": 0.1829833984375}, {"start": 3157.33, "end": 3158.17, "word": " such", "probability": 0.9443359375}, {"start": 3158.17, "end": 3158.39, "word": " as", "probability": 0.935546875}, {"start": 3158.39, "end": 3158.79, "word": " alkaline", "probability": 0.77978515625}, {"start": 3158.79, "end": 3159.21, "word": " phosphatase", "probability": 0.8343098958333334}, {"start": 3159.21, "end": 3159.35, "word": " لو", "probability": 0.8359375}, {"start": 3159.35, "end": 3159.79, "word": " فحصنا", "probability": 0.9256591796875}, {"start": 3159.79, "end": 3159.91, 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..36416a7b733c7896ed26eab2f69de8a6ded9d52f
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/KURMmQ7n_tY_raw.srt
@@ -0,0 +1,3552 @@
+1
+00:00:03,190 --> 00:00:09,150
+باسم الله الرحمن الرحيم سابق وحكينا ان ال
+
+2
+00:00:09,150 --> 00:00:13,510
+hemopoiesis هي عملية development and production of
+
+3
+00:00:13,510 --> 00:00:19,450
+cells بتتم فيها تطور
+
+4
+00:00:19,450 --> 00:00:24,710
+وندوش هذه الخلايا وقولنا عشان تتم هذه العملية
+
+5
+00:00:24,710 --> 00:00:29,810
+نحتاج إلى تلت عوامل أساسية العامل الأولاني هو وجود
+
+6
+00:00:29,810 --> 00:00:35,910
+ال stem cellو العامل التاني هو ال hemopoietic
+
+7
+00:00:35,910 --> 00:00:38,910
+micro environment و العامل التالت ال growth factor
+
+8
+00:00:38,910 --> 00:00:44,110
+وهذه عملية عملية بناء بتشبه أي عملية بناء يعني انا
+
+9
+00:00:44,110 --> 00:00:49,430
+دايما بشبهها ببناء مسجد او بناء منزل عشان تبني
+
+10
+00:00:49,430 --> 00:00:54,770
+المنزل بدك تلت شغلات بدك الأرض اللى بدك تبني عليها
+
+11
+00:00:54,770 --> 00:01:01,350
+ثم مواد البناء ثم العمال اللى بدهم يبنوا البناء
+
+12
+00:01:02,150 --> 00:01:05,370
+طبعا الأرض اللى بدنا نبنى عليها متمثلة هنا بال
+
+13
+00:01:05,370 --> 00:01:11,550
+hemopoietic micro environment ثم المواد البناء
+
+14
+00:01:11,550 --> 00:01:15,710
+متمثلة بال stem cell ثم العمال اللى هم ال
+
+15
+00:01:15,710 --> 00:01:20,770
+hemopoietic growth factor وحكينا عن ال stem cell
+
+16
+00:01:20,770 --> 00:01:26,730
+في الفيديو السابق بنوع من التفصيل ووصلنا إلى ال
+
+17
+00:01:26,730 --> 00:01:31,290
+hemopoietic micro environment ال stem cell
+
+18
+00:01:58,600 --> 00:02:04,030
+الاستمثال الاستمثال اللي وصل على سيدنا محمدحكينا
+
+19
+00:02:04,030 --> 00:02:06,390
+عليها بالتفصيل ووصلنا لل hemipotic
+
+20
+00:02:06,390 --> 00:02:11,490
+microenvironment وجونا لاستمثل لا تنمو ولا تنضج
+
+21
+00:02:11,490 --> 00:02:15,310
+إلا في special microenvironment ماذا يميز هذه ال
+
+22
+00:02:15,310 --> 00:02:23,830
+environment الذي يميزها الآتى؟ لمرة واحد إنه هي
+
+23
+00:02:23,830 --> 00:02:31,530
+عبارة عن طبقة من الخلايا اسمها stromal matrix area
+
+24
+00:02:32,570 --> 00:02:37,930
+بهذه الخلايا بتفرز
+
+25
+00:02:37,930 --> 00:02:42,830
+ال growth factors و بتزود الخلايا الغير نادجة اللي
+
+26
+00:02:42,830 --> 00:02:47,370
+بدها تاندج ب growth factor و ب nutrient عشان تتطور
+
+27
+00:02:47,370 --> 00:02:54,470
+نمرا اتنين ان الخلايا الغير نادجة على سطح ال
+
+28
+00:02:54,470 --> 00:02:59,550
+receptorsو الـ stromal cell هذه الـ stromal matrix
+
+29
+00:02:59,550 --> 00:03:03,430
+او area او الـ stromal cell اللى اللى بتبطن جدار
+
+30
+00:03:03,430 --> 00:03:08,170
+ال bone marrow ايضا عليها receptors ما يربط
+
+31
+00:03:08,170 --> 00:03:15,670
+الخلايا الغير ناضجة بالstromal cell هو certain
+
+32
+00:03:15,670 --> 00:03:21,650
+receptors و الواصلة هي عبارة عن protein، glycine،
+
+33
+00:03:21,650 --> 00:03:25,960
+moleculeأو طبعا موجودة على الـ stromal cells زي ال
+
+34
+00:03:25,960 --> 00:03:29,660
+macrofage و ال fibroblast و ال fat cells و أنا
+
+35
+00:03:29,660 --> 00:03:34,660
+هشوف الصورة بوضوح أيضا ما يميزها انه there is
+
+36
+00:03:34,660 --> 00:03:38,820
+niches lineage specific region بيسموها niches
+
+37
+00:03:38,820 --> 00:03:46,500
+احشاش موجودة في اماكن اللي هو ال ال ال bone marrow
+
+38
+00:03:46,500 --> 00:03:53,350
+او اماكن تصنيع الخلايا و بيسموا هذه المناطق هي
+
+39
+00:03:53,350 --> 00:03:58,050
+عشاش موجودة فيها أو تتمركز فيها اللي هو ال stem
+
+40
+00:03:58,050 --> 00:04:03,390
+cell و غالبا ال stem cell بتضل تمشي تمشي تمشي من
+
+41
+00:04:03,390 --> 00:04:06,830
+ال blood stream لغاية ما تصل للعش تبعها و هناك
+
+42
+00:04:06,830 --> 00:04:18,530
+بيبدأ عملية ندولها ال nices فيها micro environment
+
+43
+00:04:18,530 --> 00:04:25,700
+بتلعب دور كبيرand differentiation of proliferative
+
+44
+00:04:25,700 --> 00:04:32,860
+cell ثم أيضا بتفرز عوامل تعمل inhibition لل
+
+45
+00:04:32,860 --> 00:04:40,240
+-apoptosis طبعا هذا بيشبهو بخصائص malignant cell
+
+46
+00:04:40,240 --> 00:04:44,180
+اللي هي في myeloid leukemia اللي أصلا ما
+
+47
+00:04:47,970 --> 00:04:53,950
+أيضًا بيصير فيها prevention لمن؟ لل-apoptosis آخر
+
+48
+00:04:53,950 --> 00:04:57,390
+حاجة موجودة في ال micro environment هي ال
+
+49
+00:04:57,390 --> 00:05:03,550
+-cynosoids فتحات في أعلى ال bone marrow وهذه
+
+50
+00:05:03,550 --> 00:05:09,790
+الفتحات مبطنة ب epithelial cells معينة بتلعب دور
+
+51
+00:05:09,790 --> 00:05:16,550
+كبير في عملية إنتاج في عملية إنتاج and regulate
+
+52
+00:05:16,550 --> 00:05:17,490
+growth factors
+
+53
+00:05:24,490 --> 00:05:34,110
+وهذه الصورة بتودّه لنا الـ stromal cell و ال
+
+54
+00:05:34,110 --> 00:05:39,290
+hemobiotic cells و كيفية ارتباط كل من هما والاخر
+
+55
+00:05:39,290 --> 00:05:43,410
+هي ال stem cell بتمثل كل progenitor or immature
+
+56
+00:05:43,410 --> 00:05:47,810
+cell وهي ال stromal cell stromal cell هي أبدا عن
+
+57
+00:05:47,810 --> 00:05:52,090
+fat cell, fibroblast, macrophage, T cellو هكذا
+
+58
+00:05:52,090 --> 00:05:58,330
+كلها جاعدة على endothelial cells ماشي ثم في ترابط
+
+59
+00:05:58,330 --> 00:06:01,990
+ما بين ال immature cell و هذه الخلايا قولنا هذه
+
+60
+00:06:01,990 --> 00:06:06,310
+الخلايا بتزود ال immature cell بالأكل و بال growth
+
+61
+00:06:06,310 --> 00:06:10,990
+factor nutrient and growth factors و أيضا الخلايا
+
+62
+00:06:10,990 --> 00:06:16,210
+طول ما هي immature بتدل مرتبطة بهذه الخلاياو كل ما
+
+63
+00:06:16,210 --> 00:06:21,530
+صار فيه ندوج إلها بتبدأ تتحلل من هذه الخلايا وتن و
+
+64
+00:06:21,530 --> 00:06:25,270
+ترتقي إلى الأعلى لغاية ما تصل إلى فتحات ال bone
+
+65
+00:06:25,270 --> 00:06:30,810
+marrow في الأعلى و هناك بيبدأ عملية اللي هو خروجها
+
+66
+00:06:30,810 --> 00:06:35,710
+إلى ال peripheral blood اتفقنا
+
+67
+00:06:35,710 --> 00:06:39,390
+على أن ال stromathelm تتكون من أندث لل cell fat
+
+68
+00:06:39,390 --> 00:06:46,330
+cell fibroblastLymphocytes and macrophages وهذه هي
+
+69
+00:06:46,330 --> 00:06:51,010
+ال hemopoietic macro environment العمل الأخير في
+
+70
+00:06:51,010 --> 00:06:53,490
+ال hemopoiesis هو ال hemopoietic growth factors
+
+71
+00:06:53,490 --> 00:06:57,110
+and these are glycoprotein substance or hormones
+
+72
+00:06:57,110 --> 00:07:00,630
+لأنه they act as hormone that regulate
+
+73
+00:07:00,630 --> 00:07:04,050
+proliferation and differentiation of hemopoietic
+
+74
+00:07:04,050 --> 00:07:08,290
+progenitor cell and even can regulate the function
+
+75
+00:07:08,290 --> 00:07:12,030
+of mature cellsمن أين بيطلعوا؟ بيطلعوا من الـT
+
+76
+00:07:12,030 --> 00:07:15,570
+lymphocytes, monocytes, macrophages, stromal cell
+
+77
+00:07:15,570 --> 00:07:22,030
+and the major growth factors .. major social
+
+78
+00:07:22,030 --> 00:07:25,830
+growth factors are these cells بعد that two
+
+79
+00:07:25,830 --> 00:07:29,330
+hormone or two growth factors الأريتروبيوتين بيطلع
+
+80
+00:07:29,330 --> 00:07:34,130
+غالبا من ال kidney و ال thrombopoietin تبع ال
+
+81
+00:07:34,130 --> 00:07:40,720
+platelet بيطلع من ال liverو هذه هى صفاتهم they
+
+82
+00:07:40,720 --> 00:07:45,060
+regulate growth and differentiation شو صفاتهم ال
+
+83
+00:07:45,060 --> 00:07:49,220
+icoprotein with clinical utility صفات مميزة and
+
+84
+00:07:49,220 --> 00:07:52,300
+with clinical specificity or different specificity
+
+85
+00:07:52,300 --> 00:07:55,720
+كل واحد الوظيفته and with different origin شفنا
+
+86
+00:07:55,720 --> 00:07:59,260
+انه بيطلع من اكتر من مكان and usually bind to
+
+87
+00:07:59,260 --> 00:08:02,800
+cognate receptor برتبته بالرسبتر القريب منهم وين
+
+88
+00:08:02,800 --> 00:08:07,460
+عليبروجينياتر cell and they actlocally or at
+
+89
+00:08:07,460 --> 00:08:10,820
+distance زي صفات الهرمون بيشتغلوا على المطرح أو
+
+90
+00:08:10,820 --> 00:08:14,600
+بيشتغلواعلى الخلايا البعيدة الregulated
+
+91
+00:08:14,600 --> 00:08:17,620
+proliferation differentiation usually من صفاته
+
+92
+00:08:17,620 --> 00:08:22,600
+ايضا من صفاتهم انه they prevent apoptosis و
+
+93
+00:08:22,600 --> 00:08:26,860
+enhance the function of some end stage بمعنى انه
+
+94
+00:08:26,860 --> 00:08:30,700
+they can also regulate the function of mature stem
+
+95
+00:08:30,700 --> 00:08:36,160
+of mature cell وهذا المثال على ذلك انه GMCSF
+
+96
+00:08:36,160 --> 00:08:41,720
+اختصارا لgranulocyte, monocyteColony Stimulating
+
+97
+00:08:41,720 --> 00:08:45,560
+Factor ملعب دور كبير في الـ Function of
+
+98
+00:08:45,560 --> 00:08:52,880
+Polymorphic Nuclear Cells أمثلة
+
+99
+00:08:52,880 --> 00:08:56,120
+على Hemopoietic Growth Factor هذا هو GMCSF سميناها
+
+100
+00:08:56,120 --> 00:09:00,320
+Granulocyte Macrophage Colony Stimulating Factor
+
+101
+00:09:01,500 --> 00:09:06,040
+And macrophage colon stimulating factor من الاسم
+
+102
+00:09:06,040 --> 00:09:09,720
+الماضي انها تشتل على خلايا ال macrophage و هذه
+
+103
+00:09:09,720 --> 00:09:12,440
+كانت تشتل على ال granulocyte و ال macrophage ال
+
+104
+00:09:12,440 --> 00:09:15,980
+atheropoietin بلعب دور كبير في stimulating hormone
+
+105
+00:09:15,980 --> 00:09:22,950
+RBC stimulating hormone ثم any other factorمثل آخر
+
+106
+00:09:22,950 --> 00:09:26,570
+الترمبوبيتين بلعب دور كبير في stimulation of
+
+107
+00:09:26,570 --> 00:09:30,870
+megakaryopoiesis ال megakaryopoiesis هي عبارة عن
+
+108
+00:09:30,870 --> 00:09:36,310
+عملية ندوج أو بناء ال platelet او ال
+
+109
+00:09:36,310 --> 00:09:42,130
+megakaryocytes اللي بيطلعلي ال plateletأمثلة أخرى
+
+110
+00:09:42,130 --> 00:09:44,350
+لـ growth factor أيضًا زي مثلًا انهم colony
+
+111
+00:09:44,350 --> 00:09:48,810
+stimulating factor أيضًا they can be named by
+
+112
+00:09:48,810 --> 00:09:51,870
+interleukins of certain cytokines بتلعب دوري كبير
+
+113
+00:09:51,870 --> 00:09:54,950
+جدًا في عملية ال hemopoiesis وأمثلة على ذلك
+
+114
+00:09:54,950 --> 00:10:01,430
+interleukin 1,3,5,4,5,6 وها كذا وفي inhibitory
+
+115
+00:10:01,430 --> 00:10:03,890
+growth factor زي ال transforming growth factor
+
+116
+00:10:03,890 --> 00:10:08,070
+beta برضه يعني بيلعب في شيء بيلعب stimulating وفي
+
+117
+00:10:08,070 --> 00:10:11,730
+شيء بيلعب inhibitionوهي فيه stem cell factor بلعب
+
+118
+00:10:11,730 --> 00:10:20,170
+دور كبير على ال very immature stem cell دورهم
+
+119
+00:10:20,170 --> 00:10:25,410
+واضح جدا هذه عبارة عن ال hemopoietic tree اللي
+
+120
+00:10:25,410 --> 00:10:30,550
+قلناه pluripotent stem cell تدينا colony forming
+
+121
+00:10:30,550 --> 00:10:38,670
+unit GEMM اللي هو granulocyte erythroid macrophage
+
+122
+00:10:44,560 --> 00:10:49,590
+ميجا كاريو سايتس ومونو سايتسميجا كاريو سايتس او
+
+123
+00:10:49,590 --> 00:10:52,230
+ميجا كاريو سايتس او ميجا كاريو سايتس او ميجا كاريو
+
+124
+00:10:52,230 --> 00:10:57,150
+سايتس او
+
+125
+00:10:57,150 --> 00:11:05,650
+ميجا كاريو سايتس او ميجا كاريو سايتس او ميجا كاريو
+
+126
+00:11:05,650 --> 00:11:08,410
+سايتس او ميجا كاريو سايتس او ميجا كاريو سايتس او
+
+127
+00:11:08,410 --> 00:11:13,190
+ميجا كاريو سايتس او ميجا كاريو سايتس او ميجا كاريو
+
+128
+00:11:13,190 --> 00:11:14,810
+سايتس او ميجا كاريو سايتس او ميجا كاريو سايتس او
+
+129
+00:11:14,810 --> 00:11:17,850
+ميجا كاريو سايتس او ميجا كاريو سايتس اوcertain
+
+130
+00:11:17,850 --> 00:11:23,330
+growth factor وإن كل خطوة من هذه الخطوات تحتاج إلى
+
+131
+00:11:23,330 --> 00:11:28,210
+هذا ال growth factor لكي تتم وإن غياب هذا ال
+
+132
+00:11:28,210 --> 00:11:32,850
+growth factor لا ينقل الخلية من مرحلة إلى مرحلة
+
+133
+00:11:32,850 --> 00:11:39,870
+أثناء ندورها وبالعكس تقف الخلية عند مرحلة معينة
+
+134
+00:11:39,870 --> 00:11:45,250
+هذه أمثلة على hemipedic cytokineوالخلايا اللى
+
+135
+00:11:45,250 --> 00:11:50,190
+بتشتغل عليها طبعا مش مطالبين بحفظ هذا الموضوع لكن
+
+136
+00:11:50,190 --> 00:11:54,410
+فيه أمور رئيسية يعنى لما أقول لكوا GM CSF هتعرفوا
+
+137
+00:11:54,410 --> 00:11:57,390
+أنها بتشتغل على ال granulocyte ما أجرفيش لما أقول
+
+138
+00:11:57,390 --> 00:12:01,630
+لكوا GCSF مانتوا بيشتغل على ال granulocyte وهذه
+
+139
+00:12:01,630 --> 00:12:05,610
+صورة أخرى بتبين كل خطوة من الخطوات احتاج إلى
+
+140
+00:12:05,610 --> 00:12:10,290
+growth factor معين عشان ينقلها او interleukin عشان
+
+141
+00:12:10,290 --> 00:12:17,430
+ينقلها من مرحلة إلى مرحلةطيب ما هي ال order of
+
+142
+00:12:17,430 --> 00:12:21,150
+blood cell formation اللي هو عملية المراحل التي
+
+143
+00:12:21,150 --> 00:12:26,790
+تمر فيها orderly يعني بالترتيب ال stem cell أو
+
+144
+00:12:26,790 --> 00:12:30,930
+blood cell formation؟ قولنا أول خلية هي ال stem
+
+145
+00:12:30,930 --> 00:12:34,950
+cell و قولنا سمنها أمهات الخلايا هي الأساس لكل
+
+146
+00:12:34,950 --> 00:12:35,430
+الخلايا
+
+147
+00:12:38,090 --> 00:12:41,730
+مرحلة أخرى اسمها Progenitor Cell وقد تكون
+
+148
+00:12:41,730 --> 00:12:46,130
+Multipotential أو Bipotential أو Unipotential طبعا
+
+149
+00:12:46,130 --> 00:12:51,970
+أعرفي المصطلح Multi يعني متعددة او بتديني two line
+
+150
+00:12:51,970 --> 00:12:58,690
+او بتديني one line and المرحلة التالتة هي ال
+
+151
+00:12:58,690 --> 00:13:02,570
+precursor cells ماشي؟
+
+152
+00:13:03,770 --> 00:13:09,870
+و هذه عبارة عن بيسموها recognizable cell وهي عبارة
+
+153
+00:13:09,870 --> 00:13:14,570
+عن precursor ما قبل الندور ماشي بيسموها maturing
+
+154
+00:13:14,570 --> 00:13:20,390
+يعني in process of maturation في عملية الندور هذه
+
+155
+00:13:20,390 --> 00:13:25,540
+عبارة عن خلايا بيسميهاRecognizable cell نبدأ نعطي
+
+156
+00:13:25,540 --> 00:13:30,360
+أسماء معينة إلها ثم في النهاية بتصل الخلية في
+
+157
+00:13:30,360 --> 00:13:35,180
+نضوجها إلى ال mature form بسموها المرحلة
+
+158
+00:13:35,180 --> 00:13:42,270
+terminally differentiated cells maturing cellsوهذا
+
+159
+00:13:42,270 --> 00:13:47,710
+مثال على ذلك أيها عبارة عن خلية Stoma Cell أي خلية
+
+160
+00:13:47,710 --> 00:13:50,970
+Stem Cell متفاعلة مع Stoma Cell صارلها
+
+161
+00:13:50,970 --> 00:13:56,350
+differentiation ودتنيبروجينياتر Cell لساتنا ما
+
+162
+00:13:56,350 --> 00:14:01,150
+بنقدر نعطيها اسمها فقط بنشوفها by cultural media
+
+163
+00:14:01,150 --> 00:14:06,190
+ثم بعد ذلك بتمر الخلية في ال precursor cell وعبارة
+
+164
+00:14:06,190 --> 00:14:11,150
+عن مراحل بتمر فيها الخليةماشى لغاية ما تصل الى ال
+
+165
+00:14:11,150 --> 00:14:15,070
+mature form او recognizable form اللى بعد دارى تصل
+
+166
+00:14:15,070 --> 00:14:19,650
+الى ال mature form وده ال figure شفناها قبل هيكة
+
+167
+00:14:19,650 --> 00:14:24,330
+قولنا ان الخلية من صفاتها ان فى البداية بيكون في
+
+168
+00:14:24,330 --> 00:14:31,310
+self renewal كتير بيقل كل ما زاد الندوج وكل ما
+
+169
+00:14:31,310 --> 00:14:34,190
+صارت نادجة بيقل
+
+170
+00:14:36,470 --> 00:14:40,210
+وهنا بيصير فيه زيادة في ال differentiation بت .. و
+
+171
+00:14:40,210 --> 00:14:45,110
+شوي شوي بتقل و ال self renewal process بتشوي شوي
+
+172
+00:14:45,110 --> 00:14:50,670
+بتقل لغاية ما تصل ل ال match و ال four و هذا العكس
+
+173
+00:14:54,470 --> 00:14:57,470
+طيب ما هي صفات ال stem cell؟ جالس ال stem cell هي
+
+174
+00:14:57,470 --> 00:15:00,990
+عملها عن undifferentiated cell طبيعي هي لا نتعرف
+
+175
+00:15:00,990 --> 00:15:03,190
+عليها that give rise to all the bone marrow cell
+
+176
+00:15:03,190 --> 00:15:06,450
+قلنا هي أمهات الخلايا بتعطينا كل أنواع الخلايا
+
+177
+00:15:06,450 --> 00:15:10,010
+بتشكل فقط point five percent of all marrow cell
+
+178
+00:15:10,010 --> 00:15:15,810
+marrow nucleated cell يعني نص في المية يبقى عددها
+
+179
+00:15:15,810 --> 00:15:20,400
+قليل ولا مش قليل؟عددها قليل it's multi-potential
+
+180
+00:15:20,400 --> 00:15:24,560
+طبعا المتعددة تلقاش الجهود عشان هيك بيسموها
+
+181
+00:15:24,560 --> 00:15:28,600
+pluripotent stem cell and high self-renewal في
+
+182
+00:15:28,600 --> 00:15:32,680
+البداية بيكون في self-renewal عالي اللي بتدينا بعد
+
+183
+00:15:32,680 --> 00:15:37,500
+هيك daughter stem cell that are exact replicates
+
+184
+00:15:37,500 --> 00:15:43,920
+of the parent نفسها نفسياش ال parent cell و it's
+
+185
+00:15:43,920 --> 00:15:46,990
+not morphologically distinguishableبمعنى احنا ما
+
+186
+00:15:46,990 --> 00:15:55,090
+بنقدر نميزها و حوالي 95% من ال stem cell are out
+
+187
+00:15:55,090 --> 00:15:59,250
+of cell cycle بمعنى مش شغال فقط اللي بيعمل عملية
+
+188
+00:15:59,250 --> 00:16:05,970
+تشغيل هو 5% من ال 0.5% اللي في ال bone marrow يعني
+
+189
+00:16:05,970 --> 00:16:15,050
+95% موجود in G node mode phase وهذا عبارة عن اللي
+
+190
+00:16:15,050 --> 00:16:21,770
+هوQuiescent phase اللي هو الساكن يعني ما الشغال ما
+
+191
+00:16:21,770 --> 00:16:27,490
+بتعمل عملية ندوج و فقط 5% هو اللي شغال وهذه نعمة
+
+192
+00:16:27,490 --> 00:16:32,390
+من نعم الخالق علينا لإنه في عندنا كام هائل من ال
+
+193
+00:16:32,390 --> 00:16:37,270
+reserves تمثل ومع ذلك من صفاتها انها بتعمل
+
+194
+00:16:37,270 --> 00:16:43,430
+continuous self renewal ماذا يميز هاجولنا على
+
+195
+00:16:43,430 --> 00:16:47,800
+سطحهاما .. كيف نتعرف عليها؟ كانوا بنتعرف عليها من
+
+196
+00:16:47,800 --> 00:16:52,840
+خلال cell surface marker بمعنى أنه في علامات على
+
+197
+00:16:52,840 --> 00:16:56,760
+سطح هذه الخلايا وجدوا أن هذه العلامات متميزة ب CD
+
+198
+00:16:56,760 --> 00:17:02,840
+34 positive 38 negative and lineage negative بمعنى
+
+199
+00:17:02,840 --> 00:17:07,780
+لساتنا مش محددين خاطصيرها and HLADR
+
+200
+00:17:17,630 --> 00:17:22,910
+مصطلحات واحدة واحدة بس ببساطة CD يعني cluster of
+
+201
+00:17:22,910 --> 00:17:30,170
+differentiation بمعنى انه كل الخلاياماشي cluster
+
+202
+00:17:30,170 --> 00:17:33,610
+مجموعة differentiation مجموعة الخلايا اللي صار لها
+
+203
+00:17:33,610 --> 00:17:37,790
+differentiation CD اختصار ليش cluster of
+
+204
+00:17:37,790 --> 00:17:43,110
+differentiation ماشي وهدب يعني ان كل الخلايا في
+
+205
+00:17:43,110 --> 00:17:47,270
+هذه المرحلة بتكون تحتوي على one marker اللي هو
+
+206
+00:17:47,270 --> 00:17:50,610
+اعطوه رقم 34 هنبدأ نفهمه
+
+207
+00:17:55,190 --> 00:17:59,190
+تعني اربعة و تلاتين ماليهاش تمنية و تلاتين لكنها
+
+208
+00:17:59,190 --> 00:18:03,610
+lineage negative بمعنى انه لسه ماحدد في خط سيرها و
+
+209
+00:18:03,610 --> 00:18:07,830
+ال HLA هو اختصار ل human leukocyte antigen اللي من
+
+210
+00:18:07,830 --> 00:18:11,890
+نوع DR مرضه هتحكي عن ايه في المستقبل ان شاء الله و
+
+211
+00:18:11,890 --> 00:18:17,530
+ال RH كلكم بتعرفوا ال progenitor cell مرحلة تانية
+
+212
+00:18:17,530 --> 00:18:20,690
+حكينا عن ال stem cell اللي قال ال progenitor cell
+
+213
+00:18:20,690 --> 00:18:26,500
+ايه عبارة عن differentiatedCell يعني بدت يستغلها
+
+214
+00:18:26,500 --> 00:18:30,720
+differentiation و بدت تقلل self renewal ability
+
+215
+00:18:30,720 --> 00:18:35,360
+عندها it's multimotential و شوي شوي بتصير
+
+216
+00:18:35,360 --> 00:18:39,960
+unilinear or committed committed يعني التلتزم بخط
+
+217
+00:18:39,960 --> 00:18:47,160
+cell بخط إنتاج واحد من الخلايا سموها commitment
+
+218
+00:18:47,160 --> 00:18:48,340
+يعني ملتزمة
+
+219
+00:18:52,140 --> 00:18:57,080
+نوع واحد من الخلايا لكنها الـ Sabrogenator بتشكل 3
+
+220
+00:18:57,080 --> 00:19:00,720
+% من الـ Total Nucleated Hemopoietic Cell في البون
+
+221
+00:19:00,720 --> 00:19:05,860
+مارو تقريبا 3% شوفوا ال stem cell نصف المية اللي
+
+222
+00:19:05,860 --> 00:19:14,760
+بدت تزيد هذه صارت 3% من البون مارو stem cell طيب
+
+223
+00:19:14,760 --> 00:19:18,020
+ال
+
+224
+00:19:18,020 --> 00:19:18,360
+..
+
+225
+00:19:27,410 --> 00:19:31,290
+It forms colonies of cell in semi-solid media يعني
+
+226
+00:19:31,290 --> 00:19:36,730
+احنا نتعرف عليها in vitro في culture media
+
+227
+00:19:36,730 --> 00:19:41,030
+وبنشوفها على شكل colony forming unit فقط colonies
+
+228
+00:19:42,550 --> 00:19:46,210
+ما بنتعرف عليها، ما بنتيهاش اسمها لإنها كلها زي
+
+229
+00:19:46,210 --> 00:19:51,470
+بعض، كلها إلها نفس الشكل، أول هذه الخلايا اللي
+
+230
+00:19:51,470 --> 00:19:55,850
+بتتكون هي CFU يعني كل ال uniform unit GEMM
+
+231
+00:19:55,850 --> 00:19:58,130
+وقولنالكوا هذه اختصار اللي جرانا رساعت
+
+232
+00:19:58,130 --> 00:20:03,010
+Erythrocytic Monocytic Megakaryocytic Series
+
+233
+00:20:06,860 --> 00:20:09,160
+وطبعا الـ survival and differentiation of the
+
+234
+00:20:09,160 --> 00:20:12,700
+progenitor cell is influenced by a certain growth
+
+235
+00:20:12,700 --> 00:20:19,220
+factor و هؤلاء الفكتورات مسمى cytokine بما فيها
+
+236
+00:20:19,220 --> 00:20:21,360
+الانترلوكين والكونان ال stimulating factor
+
+237
+00:20:21,360 --> 00:20:24,600
+البروجينيتر البروجينيتر البروجينيتر البروجينيتر
+
+238
+00:20:24,600 --> 00:20:27,580
+البروجينيتر البروجينيتر البروجينيتر البروجينيتر
+
+239
+00:20:27,580 --> 00:20:33,140
+البروجينيتر البروجينيتر البروجينيتر البروجينيتر
+
+240
+00:20:33,140 --> 00:20:35,020
+البروجينيتر البروجينيتر البروجينيتر البروجينيتر
+
+241
+00:20:35,020 --> 00:20:35,020
+البروجينيتر البروجينيتر البروجينيتر البروجينيتر
+
+242
+00:20:35,020 --> 00:20:36,140
+البروجينيتر البروجينيتر البروجينيتر البروجيني
+
+243
+00:20:37,480 --> 00:20:40,900
+maturing blood cell majority of the cell طبعا معظم
+
+244
+00:20:40,900 --> 00:20:46,860
+الخلايا بتشكل ال mature blood cell أكتر من 95% من
+
+245
+00:20:46,860 --> 00:20:51,880
+الخلايا it lose adherence receptor قلتلكوا and
+
+246
+00:20:51,880 --> 00:20:55,360
+become deformable قلتلكوا أنه كل ما الخلايا نضجت
+
+247
+00:20:55,360 --> 00:20:59,080
+كل ما تحررت من ال stromal cell وبدت تطفو إلى
+
+248
+00:20:59,080 --> 00:21:02,440
+الأعلى و لغاية ما تصل ال sinusoid ال sinusoid يعني
+
+249
+00:21:02,440 --> 00:21:05,980
+فتحات البومة وين بتصب هذه الفتحات في ال
+
+250
+00:21:05,980 --> 00:21:06,660
+peripheral؟
+
+251
+00:21:09,320 --> 00:21:12,780
+Migrate through cytoplasm of lining endothelial
+
+252
+00:21:12,780 --> 00:21:17,780
+cell to intercyanoside تلقم تصل الـcyanoside ثم
+
+253
+00:21:17,780 --> 00:21:22,200
+طبعا ما عدا الـplatelet الـplatelet is are the
+
+254
+00:21:22,200 --> 00:21:25,800
+exception الـmegakaryocytes
+
+255
+00:21:25,800 --> 00:21:32,390
+أصلا هي موجودة في الـcyanosida الأولهي نخلة كبيرة
+
+256
+00:21:32,390 --> 00:21:36,030
+جدا ومنع تكون موجودة جوا داخل ال bone marrow لإنها
+
+257
+00:21:36,030 --> 00:21:40,470
+بتاخد حيزة كبيرة جدا من ال bone marrow فربنا نحطها
+
+258
+00:21:40,470 --> 00:21:45,430
+جنب ال sinuses وبالتالي they form a long process
+
+259
+00:21:45,430 --> 00:21:49,770
+of propylated which fragments into some nascent
+
+260
+00:21:49,770 --> 00:21:52,730
+platelets يعني شوي شوي ان شاء الله قدام حاجة أشرحك
+
+261
+00:21:52,730 --> 00:21:57,670
+كيف تتم عملية ال mega cardioparesisالـ phenotype
+
+262
+00:21:57,670 --> 00:22:01,150
+تبع الـ hemopoietic stem cell حاكن عليه ده هو
+
+263
+00:22:01,150 --> 00:22:05,130
+positive و negative ال regulation بتتم من خلال
+
+264
+00:22:05,130 --> 00:22:10,350
+التلت عمليات القاتلة نمرا واحد local micro
+
+265
+00:22:10,350 --> 00:22:18,250
+environment control وقولنا ال local control بتتم
+
+266
+00:22:18,250 --> 00:22:23,850
+من خلال ال micro environment نفسها ثم ال humoral
+
+267
+00:22:24,510 --> 00:22:28,410
+regulation اللى هو من خلال ال growth factor ثم فى
+
+268
+00:22:28,410 --> 00:22:32,450
+عامل آخر اللى ايضا regulate the process وهو ال
+
+269
+00:22:32,450 --> 00:22:36,470
+apoptosis عملية موت الخلايا طبعا إذا كان الخلايا
+
+270
+00:22:36,470 --> 00:22:40,190
+انمنعت من الموت بتدل عايشها فهو عامل ايضا من
+
+271
+00:22:40,190 --> 00:22:45,010
+العوامل المهمة يبجأ تلت عوامل أساسية بتعمل
+
+272
+00:22:45,010 --> 00:22:48,470
+regulation للموبيسس micro environment و ال growth
+
+273
+00:22:48,470 --> 00:22:54,360
+factor و ال apoptosis عمال اللى بيعملواطبعا كيف
+
+274
+00:22:54,360 --> 00:22:57,940
+بتتم عملية ال regulation of hemopoiesis by growth
+
+275
+00:22:57,940 --> 00:23:02,160
+factor؟ طبعا هذا الكلام أنا مش راح أشعره إياه لإن
+
+276
+00:23:02,160 --> 00:23:05,280
+انتوا خدتوه في ال micro molecular biology و هو
+
+277
+00:23:05,280 --> 00:23:07,880
+كيفية الترتباط ل growth factor بال receptor تبعه
+
+278
+00:23:07,880 --> 00:23:11,540
+بيصير فيه signal transduction بمعنى أنه بتتولد
+
+279
+00:23:11,540 --> 00:23:16,980
+مجموعة من التفاعلات متى مرتبطة بال receptor بتتولد
+
+280
+00:23:16,980 --> 00:23:21,200
+مجموعة من التفاعلات أو لبروتيناتأو الأحداث
+
+281
+00:23:21,200 --> 00:23:25,920
+الداخلية اللى واحد بنشط التانى و التانى بنشط
+
+282
+00:23:25,920 --> 00:23:29,640
+التالت لغاية ما نصل الى ال nucleus و هناك بيصير
+
+283
+00:23:29,640 --> 00:23:38,940
+فيه وظيفة يسمى العملية signal transduction ماشى
+
+284
+00:23:38,940 --> 00:23:44,180
+قولنا الapoptosis عملية مهمة جدا فى ال hemapoiesis
+
+285
+00:23:44,180 --> 00:23:48,560
+قولنا بنعرف الapoptosis هو program cell death ماشى
+
+286
+00:23:50,360 --> 00:23:57,280
+لكن الخلية ممكن تنجو من موت ال program cell death
+
+287
+00:23:57,280 --> 00:24:01,280
+by specific growth factor by certain gene by
+
+288
+00:24:01,280 --> 00:24:05,900
+specific antigen and some viruses وهذا برضه أخدته
+
+289
+00:24:05,900 --> 00:24:09,800
+في ال molecular biology وهو ال mechanism of
+
+290
+00:24:09,800 --> 00:24:15,700
+apoptosis وكيفية تنشيط الكاسابيسيز ميكانزم اللي
+
+291
+00:24:15,700 --> 00:24:16,340
+بيودي في
+
+292
+00:24:24,730 --> 00:24:28,950
+death of cell برنامج death of cell برنامج death of
+
+293
+00:24:28,950 --> 00:24:31,130
+cell برنامج death of cell برنامج death of cell
+
+294
+00:24:31,130 --> 00:24:33,970
+برنامج death of cell برنامج death of cell برنامج
+
+295
+00:24:33,970 --> 00:24:35,470
+death of cell برنامج death of cell برنامج death of
+
+296
+00:24:35,470 --> 00:24:37,150
+cell برنامج death of cell برنامج death of cell
+
+297
+00:24:37,150 --> 00:24:37,470
+برنامج death of cell برنامج death of cell برنامج
+
+298
+00:24:37,470 --> 00:24:37,470
+death of cell برنامج death of cell برنامج death of
+
+299
+00:24:37,470 --> 00:24:37,590
+cell برنامج death of cell برنامج death of cell
+
+300
+00:24:37,590 --> 00:24:37,590
+برنامج death of cell برنامج death of cell برنامج
+
+301
+00:24:37,590 --> 00:24:42,290
+death of cell برنامج death of cell برنامج death of
+
+302
+00:24:42,290 --> 00:24:49,990
+cell برنامج death of cell برنامج death of cell
+
+303
+00:24:49,990 --> 00:24:53,950
+برنامج death of cell برنامج death of cell برناإذا
+
+304
+00:24:53,950 --> 00:24:58,470
+صار في خلل بيعملنا حالة مرضية مثال عليها ال
+
+305
+00:24:58,470 --> 00:25:03,470
+chronic lymphocytic leukemia وهذه عبارة عن خلايا
+
+306
+00:25:03,470 --> 00:25:09,090
+بتعمل أو بتقاوم ال chemotherapy ان
+
+307
+00:25:09,090 --> 00:25:14,550
+شاء الله هنتطرق الليلة الموضوع هذا بالتفصيل في ال
+
+308
+00:25:14,550 --> 00:25:15,350
+leukemia
+
+309
+00:25:20,690 --> 00:25:24,870
+الـ hemopoiesis بمعنى كيف بتتعرف ال hemopoiesis
+
+310
+00:25:24,870 --> 00:25:29,670
+شغال ولا مش شغال؟ قالوا they can be assessed by
+
+311
+00:25:29,670 --> 00:25:34,130
+the following نمرا واحد اعمل CBC طبعا ال CBC
+
+312
+00:25:34,130 --> 00:25:38,390
+هيبينك ال normal ranges of blood cell ولا إذا في
+
+313
+00:25:38,390 --> 00:25:43,050
+ال normal معناته ال hemopoietic activity شغالة
+
+314
+00:25:43,050 --> 00:25:48,610
+منيح وإذا مش في ال normalبعد وفيه خلق يبقى CPC أو
+
+315
+00:25:48,610 --> 00:25:52,550
+full blood count أو complete blood count و أحد
+
+316
+00:25:52,550 --> 00:25:57,040
+العوامل أمرا اتنينأفحص البونمارو نفسه طب كيف بتم
+
+317
+00:25:57,040 --> 00:26:02,640
+عملية فحص البونمارو by aspiration ماشي وهذه طبعا
+
+318
+00:26:02,640 --> 00:26:08,600
+بتدينا فكرة عن later stages of maturation of
+
+319
+00:26:08,600 --> 00:26:12,360
+hemopoietic cells لإن و احنا خشين على البونمارو و
+
+320
+00:26:12,360 --> 00:26:18,230
+شوفنا الخلايا و مراحل ندوشها و بنقدر افهم خلاصفي
+
+321
+00:26:18,230 --> 00:26:22,130
+هذه الحالة نعرف إذا كان الخلايا ماشية صح أو في
+
+322
+00:26:22,130 --> 00:26:26,310
+خلال في الندوج أو واقف في الندوج عند مرحلة معينة و
+
+323
+00:26:26,310 --> 00:26:31,570
+هكذا نبرى تلاتة انت بدل ما تاخد aspiration تماما
+
+324
+00:26:31,570 --> 00:26:35,490
+ممكن تاخد اللي هو biopsy من ال bone marrow وهذا
+
+325
+00:26:35,490 --> 00:26:40,350
+بيبين لنا إذا كان ال bone marrow architecture
+
+326
+00:26:40,350 --> 00:26:47,890
+normal ولا abnormal بمعنىالبولمارو في إنتاج أو
+
+327
+00:26:47,890 --> 00:26:54,350
+مافي إنتاج للبولمارو البولمارو aspiration بتتم من
+
+328
+00:26:54,350 --> 00:27:00,910
+هذه المرحلة فده هنا بناخد في نسحة
+
+329
+00:27:00,910 --> 00:27:06,370
+عينات البولمارو من هذه المنطقة وهي هذه المنطقة
+
+330
+00:27:06,370 --> 00:27:12,830
+بيسموهاEliac crest وبما انها خلفية بينام الواحد
+
+331
+00:27:12,830 --> 00:27:17,590
+على بطنه بيسموها posterior Eliac crest وزي ما
+
+332
+00:27:17,590 --> 00:27:20,570
+انتوا شايفين هذه منطقة اهدى عظام الحود وقولنا
+
+333
+00:27:20,570 --> 00:27:24,610
+البونمارو موجود فى العظام العريضة و احسن مثال ناخد
+
+334
+00:27:24,610 --> 00:27:26,210
+او نتعلق
+
+335
+00:27:32,010 --> 00:27:36,110
+الـ Iliac crest هذه أو منطقة الاستيرنام الاستيرنام
+
+336
+00:27:36,110 --> 00:27:41,770
+بتعرفوا هي عبارة عن منطقة موجودة في الصدر شايفين
+
+337
+00:27:41,770 --> 00:27:45,310
+الإبرة لازم تكون حديدية لإن واحنا بدنا نخرج عضم
+
+338
+00:27:45,310 --> 00:27:49,690
+وبالتالي بنخرج العضم و بنزل على ال hip point و
+
+339
+00:27:49,690 --> 00:27:53,590
+هناك قدأي زي ما انتوا شايفين في مارو بس جابل
+
+340
+00:27:53,590 --> 00:27:57,570
+المارو في skin بدنا نخترقها و
+
+341
+00:28:03,030 --> 00:28:08,650
+بورمارو باركتكتشاراحنا من خلال الـ biopsy ممكن
+
+342
+00:28:08,650 --> 00:28:11,550
+نشوف انه ال bomber و architecture is normal ولا لأ
+
+343
+00:28:11,550 --> 00:28:15,150
+يعني cellular ولا not cellular يعني في غلايا ولا
+
+344
+00:28:15,150 --> 00:28:19,730
+مافيش غلايا فيه إذا كان الشكل هذا موجود معناته
+
+345
+00:28:19,730 --> 00:28:23,290
+hypercellular إذا كان الشكل هذا موجود معناته
+
+346
+00:28:23,290 --> 00:28:26,450
+normal cellular وإذا كان زي ما انتوا شايفين follow
+
+347
+00:28:26,450 --> 00:28:32,330
+fat cell معناته hypocellular مافي إنتاج لمين لل
+
+348
+00:28:32,330 --> 00:28:32,650
+bomber
+
+349
+00:28:35,540 --> 00:28:40,680
+الـ M.E. Ratio هي عبارة عن Myeloid إيريثرويد ريشيو
+
+350
+00:28:40,680 --> 00:28:46,520
+نسبة خلايا الـ Myeloid للإيريثرويد في الـ bone
+
+351
+00:28:46,520 --> 00:28:53,640
+marrow بسموها M.E. Ratio وهي طبيعي وهو أحد عوامل
+
+352
+00:28:53,640 --> 00:28:57,180
+الـ assessment of bone marrow بمعنى تقييم الـ bone
+
+353
+00:28:57,180 --> 00:29:02,520
+marrowالقيمة الطبيعية تبعتها من تلاتة إلى أربع
+
+354
+00:29:02,520 --> 00:29:08,180
+أضعاف ال myeloid cell بالنسبة لل erythroid cell
+
+355
+00:29:08,180 --> 00:29:13,140
+وده طبيعي جدا أنه يكون في هنا صحيح أنه عدد كبير من
+
+356
+00:29:13,140 --> 00:29:16,740
+ال myeloid أولا من ال erythroid أولا ال erythroid
+
+357
+00:29:16,740 --> 00:29:22,060
+حجمها صغير جدا بالنسبة لل myeloid نمر اتنين يعني
+
+358
+00:29:22,060 --> 00:29:26,420
+أقل من النص أو النص نمر اتنين ال myeloid عندها عدة
+
+359
+00:29:26,420 --> 00:29:30,930
+أنواعبينما الارثرويد ما هو احده بالتالي طبيعي جدا
+
+360
+00:29:30,930 --> 00:29:35,990
+ان ال myeloid تكون نسبتها اكتر في ال bone marrow
+
+361
+00:29:35,990 --> 00:29:39,350
+طبعا هذه في بعض الحالات المرضية ممكن نسبة هذه
+
+362
+00:29:39,350 --> 00:29:45,690
+تنعكس على سبيل المثال و من خلالها بنقدر نقيم ال
+
+363
+00:29:45,690 --> 00:29:51,140
+bone marrowنورمال بلاتز المنتج النهائي للخلايا زي
+
+364
+00:29:51,140 --> 00:29:56,480
+ما انتوا شايفين في عندنا immature طبعا هذه band
+
+365
+00:29:56,480 --> 00:30:00,940
+نيوتروفيل وانا بعرف انكوا أخدتوا ال differential
+
+366
+00:30:00,940 --> 00:30:06,800
+في المقدمة وحتاخدوه ان شاء الله في علم الدم العملي
+
+367
+00:30:06,800 --> 00:30:11,400
+هذه ايزينوفيل هذه segmented نيوتروفيل بيزوفيل
+
+368
+00:30:11,400 --> 00:30:15,840
+large lymphocytes and monocytes النوع مختلفة من
+
+369
+00:30:15,840 --> 00:30:16,200
+ايش
+
+370
+00:30:19,280 --> 00:30:25,120
+و نصل الـ Erythropoiesis قلتلكوا انا الخلايابتمر
+
+371
+00:30:25,120 --> 00:30:29,180
+في أربع مراحل أساسية الأولى stem cell ثم
+
+372
+00:30:29,180 --> 00:30:34,020
+progenitor cell ثم precursor cell اللى بتوصلنا لل
+
+373
+00:30:34,020 --> 00:30:38,360
+recognizable form بمعنى نصل لمرحلة أن الخلايا
+
+374
+00:30:38,360 --> 00:30:43,760
+بتصير لها أسماء نقدر ننميز بين الخلايا المختلفة
+
+375
+00:30:43,760 --> 00:30:47,400
+عشان نصل في النهاية ل mature form of cell في
+
+376
+00:30:47,400 --> 00:30:49,380
+الاريthropoiesis قالوا
+
+377
+00:30:54,920 --> 00:30:58,400
+بنكون .. بنشوف أول خلية بيسموها Pro-erythroplast
+
+378
+00:30:58,400 --> 00:31:07,080
+ثم بعد ذلك تندش وتمر في 6 مراحل مختلفة كل مرحلة
+
+379
+00:31:07,080 --> 00:31:12,360
+لازم فبالتالي أول مرحلة هي Pro-erythroplast ثم
+
+380
+00:31:12,360 --> 00:31:20,460
+Erythroplast بتتكون من تلت أنواعإن هو الأولاني
+
+381
+00:31:20,460 --> 00:31:23,960
+بيزوفيليك والتاني polychromatophilic والتالت
+
+382
+00:31:23,960 --> 00:31:28,900
+orthochromatic erythroplast ماشي يعني تلاتة أو
+
+383
+00:31:28,900 --> 00:31:32,560
+واحدة جديد صاروا أربع مرحلة الخامسة هي
+
+384
+00:31:32,560 --> 00:31:37,040
+reticulocyte ثم المرحلة السادسة هي mature
+
+385
+00:31:37,040 --> 00:31:47,180
+erythroplast ماشي وهذا هي الأشكال المختلفة أيها
+
+386
+00:31:47,180 --> 00:31:52,470
+proerythroplastاو بيسموها بعض مرات pronormoblast
+
+387
+00:31:52,470 --> 00:31:59,770
+ثم النورموبلاست اللي هم تلاتة او الارتروبلاست اللي
+
+388
+00:31:59,770 --> 00:32:03,510
+هم تلاتة بيزوفيليك و بوليكروماتيك و ال
+
+389
+00:32:03,510 --> 00:32:09,950
+orthochromic ثم ال .. هاي المرحلة الأخيرة من ال
+
+390
+00:32:09,950 --> 00:32:13,150
+orthochromic ثم بعد ذلك ال reticulocyte و ال
+
+391
+00:32:13,150 --> 00:32:19,140
+matureماشي و يسبق هذه العوامل زى ما قلتلكوا ان
+
+392
+00:32:19,140 --> 00:32:25,340
+الخلية بتكون غير معروفة نقدرش نديها اسم يعنى، ماشي
+
+393
+00:32:25,340 --> 00:32:28,300
+طب كيف نتعرف عليها؟ انه فيها Hemopoiesis جاله by
+
+394
+00:32:28,300 --> 00:32:31,600
+culture technique بنشوفها يعنى ايه؟ الخلية
+
+395
+00:32:31,600 --> 00:32:36,980
+الاستمثل لو أخدناها و زرعناها في مرحلة مقتقدمة في
+
+396
+00:32:36,980 --> 00:32:40,540
+culture media هتدينى burst forming unit ال burst
+
+397
+00:32:40,540 --> 00:32:45,970
+معناتها انفجار بتعمل انفجار كبير من المن الخلايا
+
+398
+00:32:45,970 --> 00:32:51,630
+وفي هذه الحالة تدينا thousands of nucleated
+
+399
+00:32:51,630 --> 00:32:58,350
+erythroid in V2 in culture يعني و under some
+
+400
+00:32:58,350 --> 00:33:03,210
+changes it become colony forming unit erythroid
+
+401
+00:33:03,210 --> 00:33:07,070
+يعني بنضيفلها hormone ال erythropoietin فبالتالي
+
+402
+00:33:07,070 --> 00:33:11,490
+بتتطور لغاية ما تصل ل colony forming unit او في
+
+403
+00:33:11,490 --> 00:33:13,730
+هذه المرحلة بيكون ال controller
+
+404
+00:33:18,760 --> 00:33:22,920
+هي ال colony forming unit صارت well differentiated
+
+405
+00:33:22,920 --> 00:33:30,040
+present only in red bone marrow كان form up to 40
+
+406
+00:33:30,040 --> 00:33:35,980
+.. 64 nucleated erythroid precursors و ال hormone
+
+407
+00:33:35,980 --> 00:33:41,280
+اللي بيتحكم فيها ال erythropoietin لغاية الأن
+
+408
+00:33:41,280 --> 00:33:45,540
+مقدرش نميز بينهم except in vitro culture method
+
+409
+00:33:47,090 --> 00:33:50,770
+الان بنجي ل ال recognizable fold هو اول مرحلة
+
+410
+00:33:50,770 --> 00:33:56,170
+normal blast precursor وهذه حجمه كبير 15-20
+
+411
+00:33:56,170 --> 00:33:59,770
+مايكرون ال cytoplasm زي ما انتوا شايفينه ديب
+
+412
+00:33:59,770 --> 00:34:05,810
+violet to blue لازالت الخلية غير قادرة على إنتاج
+
+413
+00:34:05,810 --> 00:34:12,810
+ال hemoglobin فيها nucleus كبيرة بشكل حجم عمال 12
+
+414
+00:34:12,810 --> 00:34:13,470
+مايكرون
+
+415
+00:34:16,660 --> 00:34:24,680
+و بتملى حوالي تلت ترباع الخلية و ال nucleus has
+
+416
+00:34:24,680 --> 00:34:31,840
+fine-stemmed لا زالت ال DNA تبعها is fine منقطة
+
+417
+00:34:31,840 --> 00:34:36,140
+stemmed articulate و لو طلعنا هنلاجي في many
+
+418
+00:34:36,140 --> 00:34:38,500
+nuclei موجودة
+
+419
+00:34:41,530 --> 00:34:44,730
+ثم ما قلتلكوا تنتقل الى normal blast و ال normal
+
+420
+00:34:44,730 --> 00:34:46,890
+blast تلت مراحل اول هذه المراحل اللي هي ال
+
+421
+00:34:46,890 --> 00:34:50,450
+mesophilic تبدأ تصغر الخلية و خدوها قاعدة كل ما
+
+422
+00:34:50,450 --> 00:34:54,110
+كانت الخلية mature كل ما كانت كبيرة و كل ما صارت
+
+423
+00:34:54,110 --> 00:34:57,830
+mature كل ما بدت تصغر شوية شوية شوية لغاية ما تصل
+
+424
+00:34:57,830 --> 00:35:04,210
+الى ال mature form smaller size shows active
+
+425
+00:35:04,210 --> 00:35:11,550
+mitosis no nuclei in the nucleusfine chromatin
+
+426
+00:35:11,550 --> 00:35:17,510
+network و بدأ يزهر شوية condensation في هذه
+
+427
+00:35:17,510 --> 00:35:22,450
+المرحلة بيبدأ تصنيع ال hemoglobin لكنه still is
+
+428
+00:35:22,450 --> 00:35:31,010
+not seen ليش؟ لأن ال cytoplasm is still mesophilic
+
+429
+00:35:31,010 --> 00:35:35,280
+ال intermediateنورموبلاست اللي سمناها
+
+430
+00:35:35,280 --> 00:35:41,240
+polychromatophilic نورموبلاست حجمها نزل ل 10.14
+
+431
+00:35:41,240 --> 00:35:46,380
+مايكروم it shows active mitosis، hemoglobin
+
+432
+00:35:46,380 --> 00:35:50,260
+content is increased وهي بالتالي بدأ يلون في الـ
+
+433
+00:35:50,260 --> 00:35:53,400
+cytoplasm تبع الخلية فصار متعدد الألوان
+
+434
+00:35:53,400 --> 00:35:58,380
+polychromatophilic ثم أخر مرحلة من مراحل
+
+435
+00:35:58,380 --> 00:36:04,540
+نورموبلاستسميناها Orthochromic Normal Blast شايفين
+
+436
+00:36:04,540 --> 00:36:10,960
+كده نزل حجمها؟ 7 إلى 10 ميجروم من 15 إلى 20 ثم
+
+437
+00:36:10,960 --> 00:36:18,680
+نزلت 10 إلى 15 ثم داينا وصلنا إلى مرحلة كان صار
+
+438
+00:36:18,680 --> 00:36:23,600
+حجم الخلية فيها 7 إلى 10 ميجروم نيوكلياس شرينكز
+
+439
+00:36:23,600 --> 00:36:27,560
+تبدأ نيوكلياس أنه يصير لها shrinking and condensed
+
+440
+00:36:27,560 --> 00:36:30,140
+ماشي كروماتين material
+
+441
+00:36:35,660 --> 00:36:40,640
+الـ Cartwheel-shaped cell والـ cytoplasm بيصير
+
+442
+00:36:40,640 --> 00:36:44,440
+أزينوفلك in appearance وزي ما انتوا شايفين هي الـ
+
+443
+00:36:44,440 --> 00:36:51,320
+nucleus بدت تاخد موضع طرفي استعدادا إلى خروجها من
+
+444
+00:36:51,320 --> 00:36:56,620
+الخلية لإن الاربسيز is enucleated enucleated يعني
+
+445
+00:36:56,620 --> 00:37:00,960
+ما فيها nucleus طبعا ال reticulocyte هي الخلية ال
+
+446
+00:37:00,960 --> 00:37:06,830
+pin ultimate يعني ما قبل النهائية ال stageand it
+
+447
+00:37:06,830 --> 00:37:10,450
+has find network of reticula خلاص انطردت ال
+
+448
+00:37:10,450 --> 00:37:18,410
+nucleus برا لكن ده البقايا ماشي RNA remnant of RNA
+
+449
+00:37:18,410 --> 00:37:23,410
+بديها ال mesophilic appearance للcytoplasm في
+
+450
+00:37:23,410 --> 00:37:30,690
+الأطفال بتشوفها بكميات بتوصل من 2 ل 6 لكن
+
+451
+00:37:33,420 --> 00:37:36,720
+الى اقل من واحد يعني بتشوفها في ال peripheral
+
+452
+00:37:36,720 --> 00:37:39,440
+blood نعم بتشوفها في ال peripheral blood لأن هي
+
+453
+00:37:39,440 --> 00:37:45,180
+مرحلة ما قبل ايش ما قبل الندوج وبنشوفها
+
+454
+00:37:45,180 --> 00:37:49,080
+بكثرة في حالات الانيميا لإنه بتكون بزيد الطلب على
+
+455
+00:37:49,080 --> 00:37:54,120
+ال RBCs وبالتالي بتبدأ تنزل ال RBCs بدري فبنشوف
+
+456
+00:37:54,120 --> 00:37:59,780
+مراحل ما قبل الندوج في ال peripheral blood كتير
+
+457
+00:37:59,780 --> 00:38:04,490
+وهي شكلهابعد شهور RBCs كنا بنعرف هي عبارة عن
+
+458
+00:38:04,490 --> 00:38:08,830
+بايكون كيف ديسك اصل مش فيها نيوكلياس و هي حوالي
+
+459
+00:38:08,830 --> 00:38:15,850
+تلتها مليان بالهيموجلوبين و هذه المراحل الستة اللي
+
+460
+00:38:15,850 --> 00:38:20,090
+بتمر فيها الخلية during erythropoiesis و هي
+
+461
+00:38:20,090 --> 00:38:23,470
+بيسموها أيها proerythroplast, mesophilic ثم
+
+462
+00:38:23,470 --> 00:38:29,090
+polychromatic ثم orthochromic ثم reticulocyte بعد
+
+463
+00:38:29,090 --> 00:38:35,820
+ما تطلع النيوكلياس من الخليةثم الـ mature RBCs
+
+464
+00:38:35,820 --> 00:38:40,260
+تاني، إيش ال physiology of erythropoiesis؟ قالوا
+
+465
+00:38:40,260 --> 00:38:43,620
+فيه أربعة mitotic divisions ما بين الـ
+
+466
+00:38:43,620 --> 00:38:47,960
+pronormoblast اللي هي أول مرحلة و ال orthochromic
+
+467
+00:38:47,960 --> 00:38:56,940
+normoblast الأربعة بدون ست عشر RBCs لكن مش كل الست
+
+468
+00:38:56,940 --> 00:39:07,320
+عشر هيصلوا إلى ال matureفي منهم بيخلق تخليق خاطئ
+
+469
+00:39:07,320 --> 00:39:13,420
+and this will be destroyed وعملية ال destruction
+
+470
+00:39:13,420 --> 00:39:18,840
+لهذه الخلايا بيسموها ineffective erythropoies يعني
+
+471
+00:39:18,840 --> 00:39:24,660
+erythropoies غير فعالة يبقى أثناء عملية الإنتاج في
+
+472
+00:39:24,660 --> 00:39:33,850
+عندنا خلايا بتنتج لكنها غيرسليمة ومطلوب من الجسم
+
+473
+00:39:33,850 --> 00:39:37,250
+انه يخلصنا منها و بالفعل بيصير عملية destruction
+
+474
+00:39:37,250 --> 00:39:40,530
+لهذه الخلايا و بيسموه العملية ineffective
+
+475
+00:39:40,530 --> 00:39:46,010
+erythropoiesis جديش بتاخد العملية وجدت جاله بتاخد
+
+476
+00:39:46,010 --> 00:39:51,370
+من اتنين لسبعة أيام من البرو نورموبلاستيج لغاية ال
+
+477
+00:39:51,370 --> 00:39:56,370
+mature to mature into orthochronic بعد هيك بتاخد
+
+478
+00:39:56,370 --> 00:40:00,750
+يوم زيادة عشان تطرد ال nucleus
+
+479
+00:40:03,610 --> 00:40:08,130
+وبنصل إلى مرحلة reticulocytes اللى بتاخد من يومين
+
+480
+00:40:08,130 --> 00:40:15,550
+لتلت يام فى ال bone مروح عشان تندج ماشى بعد هيك
+
+481
+00:40:15,550 --> 00:40:22,610
+بتنزل على ال peripheral blood تقعد الخلية 120 يوم
+
+482
+00:40:22,610 --> 00:40:26,350
+فى ال peripheral blood as normal functioning
+
+483
+00:40:26,350 --> 00:40:31,770
+retropieces ودى المراحل اللى هى ال facesأي أساسها
+
+484
+00:40:31,770 --> 00:40:39,250
+من الأول stem cell بعد هي انقسمت ودتني committed
+
+485
+00:40:39,250 --> 00:40:43,370
+cell إيش يعني committed يعني التزمت بخط إنتاج ال
+
+486
+00:40:43,370 --> 00:40:50,470
+RBCs فبدت تديني Pro-Oedoplast ثم في عندنا إيش
+
+487
+00:40:50,470 --> 00:40:58,420
+Mitotica يعني ال phases أول phaseبتصير yearly
+
+488
+00:40:58,420 --> 00:41:02,460
+erythropoiesis ثم الفيزي التاني في late
+
+489
+00:41:02,460 --> 00:41:05,020
+erythropoiesis وفي هذا الفيز بنشوف hemoglobin
+
+490
+00:41:05,020 --> 00:41:09,540
+accumulation هذا هي لغاية ما نصل للفيزي التالت وهو
+
+491
+00:41:09,540 --> 00:41:14,960
+ال ejection أو النيكلياس ترض الخلية انه من الخلية
+
+492
+00:41:14,960 --> 00:41:22,700
+ما هي العوامل التي تؤثر او تتحكم في عملية ال
+
+493
+00:41:22,700 --> 00:41:25,740
+erythropoiesis دلوقت فيها اكتر معامل اهم هذه
+
+494
+00:41:25,740 --> 00:41:30,760
+العواملهو tissue oxygenation احنا عارفين ان ال
+
+495
+00:41:30,760 --> 00:41:37,580
+RBCs وظيفتها هي حملة ال oxygen فبالتالي ال oxygen
+
+496
+00:41:37,580 --> 00:41:45,360
+هو عامل مهم في عملية إنتاج او التحكم في إنتاج ال
+
+497
+00:41:45,360 --> 00:41:51,260
+RBCs ثم first promoting activity هذا نالكوهرمون
+
+498
+00:41:51,260 --> 00:41:54,200
+بيتحكم في أول مرحلة من المراحل اللي are
+
+499
+00:41:54,200 --> 00:42:00,540
+erythropoiesisثم الارتروبيتين بيتحكم في كل مراحل
+
+500
+00:42:00,540 --> 00:42:04,380
+ما بعد ذلك حتى في بعض المقالات بتقول انه بيتحكم
+
+501
+00:42:04,380 --> 00:42:09,040
+بال function of mature RBCs وفي مقالات بتقول لأ
+
+502
+00:42:09,040 --> 00:42:14,480
+لغاية ال M لغاية ال mature و بجاف ثم ال iron هو ال
+
+503
+00:42:14,480 --> 00:42:18,400
+iron ملزمة في تصنيع ال hemoglobin فإذا كان خلية
+
+504
+00:42:18,400 --> 00:42:20,840
+بدها تصنع hemoglobin إذا مافيش iron كده بدها تصنع
+
+505
+00:42:20,840 --> 00:42:27,660
+فبتجاف في Mالندوج ثم ال vitamin ملزمنا ال vitamin
+
+506
+00:42:27,660 --> 00:42:33,220
+B12 and folic acid عشان DNA synthesis وبعض العوامل
+
+507
+00:42:33,220 --> 00:42:39,240
+الأخرى زي الكبر و ال zinc و ال magnesium sorry ال
+
+508
+00:42:39,240 --> 00:42:43,640
+erythropoietin هو عبارة عن hormone كلنا بينتج من
+
+509
+00:42:43,640 --> 00:42:48,800
+الكدنى هو عبارة عن glycoprotein substance و اليوم
+
+510
+00:42:48,800 --> 00:42:56,240
+موجود منهأبولات صناعية إبر صناعية يعني مصنع by
+
+511
+00:42:56,240 --> 00:43:01,220
+يعني
+
+512
+00:43:01,220 --> 00:43:07,760
+مصانع خارجية بيشتغل على ال colony forming unit
+
+513
+00:43:07,760 --> 00:43:12,200
+إيريثرويد منها لغاية الآخر وزيفته الأساسية
+
+514
+00:43:12,200 --> 00:43:16,000
+increase the number of nucleated precursor in the
+
+515
+00:43:16,000 --> 00:43:19,280
+bone marrow و
+
+516
+00:43:20,660 --> 00:43:23,880
+زي ما قلتلكوا ده هو الـ reticulocyte الـ mature
+
+517
+00:43:23,880 --> 00:43:29,660
+RBCs in the blood بيبدأ يزيد عددها ويتامين أهمه
+
+518
+00:43:29,660 --> 00:43:33,940
+vitamin B12 ان شاء الله هناخده بالتفصيل قدام وهو
+
+519
+00:43:33,940 --> 00:43:37,500
+عبارة عن الـ cyanocopalamine و ال folic acid
+
+520
+00:43:37,500 --> 00:43:42,640
+التانين بلزموه ك vitamins في هذه العملية واحد
+
+521
+00:43:42,640 --> 00:43:47,760
+بيسموه Extrinsic factor of Castle وبيحتاج إلى
+
+522
+00:43:47,760 --> 00:43:53,490
+Intrinsic factorوهو ان شاء الله هنحكي فيه بالتفصيل
+
+523
+00:43:53,490 --> 00:43:58,050
+قدام وإذا مافيش intrinsic factor بيصير فيه حاجة
+
+524
+00:43:58,050 --> 00:44:01,270
+بيسموها pernicious anemia وهي نوع من أنواع ال
+
+525
+00:44:01,270 --> 00:44:06,670
+megaloplastic anemia ال vitamin أيضا stimulate
+
+526
+00:44:06,670 --> 00:44:11,370
+erythropoiesis ووجدوا أن هذه ال vitamin موجودة في
+
+527
+00:44:11,370 --> 00:44:16,010
+ال meat و ال diary products ال iron ضروري جدا في
+
+528
+00:44:16,010 --> 00:44:19,690
+تصنيع ال hemoglobinغيابه بيعمل microcytic
+
+529
+00:44:19,690 --> 00:44:25,670
+hypochromic anemia و تبدأ تتأثر ال blood indices
+
+530
+00:44:25,670 --> 00:44:34,950
+ال MCV و ال MCH و ال MCHC are low و عملية ال
+
+531
+00:44:34,950 --> 00:44:39,010
+regulation بالتم كالقاتي لاحظوا هاي ال aerosol
+
+532
+00:44:39,010 --> 00:44:43,250
+protein هاي ال aerosol protein بالأخضرالـ
+
+533
+00:44:43,250 --> 00:44:45,810
+regulation بتتم من فوق الـ colon stimulating
+
+534
+00:44:45,810 --> 00:44:49,270
+factor الـ colon forming unit الارترويد وهي
+
+535
+00:44:49,270 --> 00:44:54,030
+البروارترويد بأول الارتروبلاست ثم ال mature طب إيش
+
+536
+00:44:54,030 --> 00:44:58,530
+اللي بيصير؟ قالوا لما هذه العواملات قل tissue
+
+537
+00:44:58,530 --> 00:45:03,430
+oxygenation is decreased و وقتش بيصير عملية
+
+538
+00:45:03,430 --> 00:45:09,230
+decreasing لل oxygen زي في حالة الhypovolemia
+
+539
+00:45:12,220 --> 00:45:15,640
+الـ poor blood flow أو في حالات الـ pulmonary
+
+540
+00:45:15,640 --> 00:45:22,080
+disease شو اللي بيصير بيقل الأكسجين فلما يقل
+
+541
+00:45:22,080 --> 00:45:27,380
+الأكسجين تتحسس الكدني قلة الأكسجين فبتروح أيام طلع
+
+542
+00:45:27,380 --> 00:45:32,820
+الارترابويتين شو بيعمل الارترابويتين؟ قالوا بيشتغل
+
+543
+00:45:32,820 --> 00:45:36,600
+على عملية الارترابويس من الأول على ال colon
+
+544
+00:45:36,600 --> 00:45:43,320
+forming unit الارترويد و مبدأشبيبدأ يزودها المحصلة
+
+545
+00:45:43,320 --> 00:45:50,180
+زيادة في إنتاج ال RBCs ومتى ما زادت ال RBCs في
+
+546
+00:45:50,180 --> 00:45:55,360
+العدد بتحمل أكسجين أكتر وبالتالي بتقل عملية ال
+
+547
+00:45:55,360 --> 00:46:02,820
+decrease in tissue oxygenation الارثوكيهتين وظاهته
+
+548
+00:46:02,820 --> 00:46:09,010
+activated stem cell of bone marrowShortening cell
+
+549
+00:46:09,010 --> 00:46:13,570
+cycle ضروري جدا عشان نسرع في عملية إنتاج ال RBCs
+
+550
+00:46:13,570 --> 00:46:18,550
+ثم Decrease maturation time بدل ما تاخد وقت كبير
+
+551
+00:46:18,550 --> 00:46:22,890
+في عملية ال maturation بصير قليل ثم Increase rate
+
+552
+00:46:22,890 --> 00:46:28,410
+of mitosis and maturation process السرعة بتزيد
+
+553
+00:46:28,410 --> 00:46:34,860
+Increase rate of hemoglobinأيضا سرعة إمتاج
+
+554
+00:46:34,860 --> 00:46:39,560
+الهيموجلومي المزيد تسبب في تنزيل عدد الرتكيلوسايد
+
+555
+00:46:39,560 --> 00:46:44,580
+بكمية
+
+556
+00:46:44,580 --> 00:46:51,560
+أكبر ومن أهم وضعفه أيضا تمنع الابوبتوسس وده
+
+557
+00:46:51,560 --> 00:46:55,480
+الارتفوبيتين ريسبتور وده زي ما انتوا شايفين
+
+558
+00:46:58,110 --> 00:47:01,670
+هو يتكوّن ويرتبط بالـ Ligand تبعه وهو الـ Receptor
+
+559
+00:47:01,670 --> 00:47:07,010
+وهو الـ Ligand فببدأ يتنشط سلسلة من ال
+
+560
+00:47:07,010 --> 00:47:11,510
+Transcriptional Factor اللي في النهاية بتزود لنا
+
+561
+00:47:11,510 --> 00:47:15,090
+عملية ال Erythropoiesis
+
+562
+00:47:18,140 --> 00:47:22,000
+هذا ما يخص الـ Erythropoiesis، الـ Granulopoiesis
+
+563
+00:47:22,000 --> 00:47:27,460
+نفس الحكاية، بدها تديني اللي هو الـ Granulocyte
+
+564
+00:47:27,460 --> 00:47:30,820
+وهي الإيزينوفيل و النيوتروفيل و البيزوفيل
+
+565
+00:47:33,880 --> 00:47:38,200
+والعملية بتتم بنفس الحالة بتمر في 6 مراحل مختلفة
+
+566
+00:47:38,200 --> 00:47:44,780
+أول مرحلة هي ال blast ثم pro myelocyte ثم
+
+567
+00:47:44,780 --> 00:47:49,960
+myelocyte ثم metamyelocyte ثم ال band ثم segmented
+
+568
+00:47:49,960 --> 00:47:56,180
+cell ماشي فهي المراحل المختلفة الستة ننتقل في ال
+
+569
+00:47:56,180 --> 00:48:01,940
+maturation أو أول مرحلة هي ال myeloblast و
+
+570
+00:48:05,590 --> 00:48:11,990
+تأخذ من 24 إلى 48 ساعة per single cycle بتمثل أقل
+
+571
+00:48:11,990 --> 00:48:15,130
+من 1% من ال bottom of the compartment الخلايا
+
+572
+00:48:15,130 --> 00:48:21,410
+كبيرة 15 إلى 20 مايكرون نوكليولاياسين و nucleus is
+
+573
+00:48:21,410 --> 00:48:25,620
+delicatesmall amount of cytoplasm with rough
+
+574
+00:48:25,620 --> 00:48:29,360
+endoplasmic reticulum بالمناسبة يا بنات ويا شباب
+
+575
+00:48:29,360 --> 00:48:33,860
+هذا الكلام هتاخده بالتفصيل الممل ان شاء الله في
+
+576
+00:48:33,860 --> 00:48:37,940
+العمل فما تجلجوش من صفات هذه الخلايا هذه بدها حفظ
+
+577
+00:48:37,940 --> 00:48:42,940
+صحيح عشان تبدأ تتعرف على الخلية من شكلها لكن
+
+578
+00:48:42,940 --> 00:48:47,220
+هانشاء الله المعلومات هذه العمل يحتاج تثبت فيها
+
+579
+00:48:55,290 --> 00:48:58,910
+المرحلة اللي بعدها Myeloblast وقلنا هذه عبارة عن
+
+580
+00:48:58,910 --> 00:49:00,830
+cytochemical staining show presence on
+
+581
+00:49:00,830 --> 00:49:05,410
+myeloperoxidase بيبدأ يتكون أول أنواع ال granules
+
+582
+00:49:05,410 --> 00:49:08,590
+لأن هذه عبارة عن granular size وأول أنواع ال
+
+583
+00:49:08,590 --> 00:49:10,870
+granules بيسموها primary granules تحتوي على
+
+584
+00:49:10,870 --> 00:49:20,330
+myeloperoxidase وهذه من أهم من وظائفها وهي اللي
+
+585
+00:49:21,780 --> 00:49:27,540
+لقتل الـ intracellular killing لأي microbe و ضروري
+
+586
+00:49:27,540 --> 00:49:31,660
+جدا ال killing أو الدفاع على نفسها يعني الخلية
+
+587
+00:49:31,660 --> 00:49:35,900
+بتدافع على نفسها في مراحل مبكرة جدا الmyeloplast
+
+588
+00:49:35,900 --> 00:49:40,040
+is incapable of motility غير قادر على الحركة and
+
+589
+00:49:40,040 --> 00:49:44,560
+adhesion and phagocytosis is therefore non
+
+590
+00:49:44,560 --> 00:49:50,450
+-functional لساتها غير قادرة على الحركةالأولى على
+
+591
+00:49:50,450 --> 00:49:57,890
+ال adhesion ننتقل الى bromilocytes وهذه تحتاج برضه
+
+592
+00:49:57,890 --> 00:50:04,230
+بعد أكتر من يوم من ال blast stage بتخش للخلية في
+
+593
+00:50:04,230 --> 00:50:09,950
+مرحلة ال bromilocytes تشكل 1 ل 5% و ال size is
+
+594
+00:50:09,950 --> 00:50:18,510
+more thanالـ Myeloplast و هذه هي القاعدة بتشذ هنا
+
+595
+00:50:18,510 --> 00:50:22,250
+فقط في هذه المرحلة احنا قلنا ان الخلية كل ما صارت
+
+596
+00:50:22,250 --> 00:50:26,670
+more mature كل ما نضجت كل ما زغرت الا انه في هذه
+
+597
+00:50:26,670 --> 00:50:33,390
+المرحلة المرحلة هذه اكبر من ايش من سابقتها Nuclear
+
+598
+00:50:33,390 --> 00:50:36,310
+chromatin may be delicate or may slide clumping,
+
+599
+00:50:36,530 --> 00:50:41,470
+nuclei begin to fadeبنبطل نشوفها موجودة لكن و إيش
+
+600
+00:50:41,470 --> 00:50:46,930
+بنبطل نشوفها أذكركم المراحل المختلفة اللي بعدها
+
+601
+00:50:46,930 --> 00:50:52,730
+هيصير في myelocytes و هنا بيبدأ يصير في تكوين ال
+
+602
+00:50:52,730 --> 00:50:58,250
+neutrophilic granules و بالذات ال secondary
+
+603
+00:50:58,250 --> 00:51:04,670
+granules و ال myelocyte is the last cell of bone
+
+604
+00:51:04,670 --> 00:51:06,790
+marrow compartment capable of mitosis
+
+605
+00:51:09,700 --> 00:51:16,980
+بتاخد حوالي أربع على خمس أيام و تبدأ الخلية تاخد
+
+606
+00:51:16,980 --> 00:51:20,560
+distinct morphological variability لأنه في هذه
+
+607
+00:51:20,560 --> 00:51:24,060
+المرحلة بما أنه بتتكون secondary granules وكل
+
+608
+00:51:24,060 --> 00:51:29,740
+granules بيختلف عن التانية بالنسبة للاختلاف
+
+609
+00:51:29,740 --> 00:51:36,220
+الخلايا فال neutrophil فيها بتاخد شكل معين ثم ال
+
+610
+00:51:36,220 --> 00:51:40,950
+isenophile شكل تاني ثم ال basophilوبالتالي في هذه
+
+611
+00:51:40,950 --> 00:51:44,410
+المرحلة تبدأ الخلية في التشكل يعني بتاخد أكتر من
+
+612
+00:51:44,410 --> 00:51:51,830
+شكل تبدأ تصغر 12 ل 18 مايكرون تشكل أقل من 10%
+
+613
+00:51:51,830 --> 00:51:56,550
+nucleus is round to oval تبدأ تصير فيه flattening
+
+614
+00:51:56,550 --> 00:52:04,650
+في side near the golgi apparatus nuclear chromatin
+
+615
+00:52:04,650 --> 00:52:08,140
+show clumping بدأ تصير فيه analogعندما لا يزال
+
+616
+00:52:08,140 --> 00:52:15,960
+نوكليولاية مظهرة. وعن بعدها قعد الميولو سايتس، في
+
+617
+00:52:15,960 --> 00:52:21,460
+متا ميولو سايتس، ناشي، بس ده هنا قبل ما نخش على
+
+618
+00:52:21,460 --> 00:52:24,800
+متا ميولو سايتس، هي secondary granule stain pink
+
+619
+00:52:29,190 --> 00:52:32,970
+يعني بدأت تتمييز or pink plush within this
+
+620
+00:52:32,970 --> 00:52:38,390
+cytoplasm شكل ال pink الزهري compounds such as
+
+621
+00:52:38,390 --> 00:52:41,090
+alkaline phosphatase لو فحصنا ال granules هلاجي
+
+622
+00:52:41,090 --> 00:52:45,630
+فيها alkaline phosphatase في ال secondary granules
+
+623
+00:52:45,630 --> 00:52:50,600
+دليل على وجود أيش secondary granulesو في هذه
+
+624
+00:52:50,600 --> 00:52:56,200
+المرحلة بتبدأ تكتسب و أحد الوظائف اللي هي تاعة ال
+
+625
+00:52:56,200 --> 00:53:00,960
+neutrophil و هي ال motility لأن هي وظيفتها بعد هيك
+
+626
+00:53:00,960 --> 00:53:05,280
+حصلت في agocytosis فلازم تتحرك باتجاه ال antigen و
+
+627
+00:53:05,280 --> 00:53:10,340
+تقتله زى ما قلتلكوا ده هي المراحلفي هذه المرحلة
+
+628
+00:53:10,340 --> 00:53:14,000
+صار في عندنا من الـ Bromilocytes صار في عندنا
+
+629
+00:53:14,000 --> 00:53:17,780
+Neutrophilic Mylocytes وXenophilic Mylocytes
+
+630
+00:53:17,780 --> 00:53:21,400
+وBasophilic Mylocytes وزي ما قلتلكوا السبب في
+
+631
+00:53:21,400 --> 00:53:28,180
+اختلاف الخلايا أو الأشكال هذه هو ال secondary
+
+632
+00:53:28,180 --> 00:53:32,480
+granules اللي تكون كل granules بياخد شكل معين
+
+633
+00:53:32,480 --> 00:53:36,540
+وبيميز الخلية بتميز معين
+
+634
+00:53:39,680 --> 00:53:44,000
+وبيزوفيل وبيزوفيل زى ما قلتلكوا بعد ال myelocyte
+
+635
+00:53:44,000 --> 00:53:47,640
+فى متا myelocyte زاد عددها من تلتاشر لاتنين وعشرين
+
+636
+00:53:47,640 --> 00:53:52,640
+في المية صغير حجمها not seen in normal blood لغاية
+
+637
+00:53:52,640 --> 00:53:57,400
+الآن ممنوع نشوفها في ال peripheral blood it's not
+
+638
+00:53:57,400 --> 00:54:02,880
+fully functioning بعد
+
+639
+00:54:02,880 --> 00:54:09,670
+هيك في ال band ودى عبارة عن مرحلة ما بينالـ Mature
+
+640
+00:54:09,670 --> 00:54:13,510
+Form of Metamylocytes هي بيسموها Transitional Form
+
+641
+00:54:13,510 --> 00:54:18,090
+و غالبا موجودة في both peripheral blood and bone
+
+642
+00:54:18,090 --> 00:54:27,230
+marrow و بتعتبر جزء of both maturation and storage
+
+643
+00:54:27,230 --> 00:54:31,660
+poolmaturation يعني في ال bone marrow و ال storage
+
+644
+00:54:31,660 --> 00:54:35,680
+pool أيضا جزء منها في ال bone marrow و جزء اخر
+
+645
+00:54:35,680 --> 00:54:37,480
+نجيه في ال peripheral blood زي ما عندنا حاجة
+
+646
+00:54:37,480 --> 00:54:43,520
+نشتغلها مثل حوالي 40% ال Brazil ده almost mature
+
+647
+00:54:43,520 --> 00:54:48,400
+يعني تقريبا كل وظائف ال mature form of neutrophil
+
+648
+00:54:48,400 --> 00:54:52,660
+موجودة عندها في motility يعني في chemotaxis في
+
+649
+00:54:52,660 --> 00:54:58,200
+adhesion و chemotaxis ثم في phagocystic abilityال
+
+650
+00:54:58,200 --> 00:55:02,620
+band form begins to produce tertiary granules في
+
+651
+00:55:02,620 --> 00:55:08,280
+هذه المرحلة بتبدأ تزهر تتزهر تتزهر تتزهر تتزهر
+
+652
+00:55:08,280 --> 00:55:13,740
+تتزهر تتزهر تتزهر تتزهر تتزهر تتزهر تتزهر
+
+653
+00:55:17,830 --> 00:55:22,670
+والـ membrane maturity shows change in skeleton
+
+654
+00:55:22,670 --> 00:55:27,410
+تبدأ تتغير اللي هو ال membrane تبعها كمان surface
+
+655
+00:55:27,410 --> 00:55:33,370
+charge موجود وفي سيرة الريسيبتل بتظهر عليها بس تخش
+
+656
+00:55:33,370 --> 00:55:36,850
+على ال peripheral blood بتشكل حوالي 6% من ال
+
+657
+00:55:36,850 --> 00:55:41,710
+circulating white bases وحجمها لاتتجاوز ال 10 ل 15
+
+658
+00:55:41,710 --> 00:55:46,440
+micron in diameterوموجودة في الـ marginating
+
+659
+00:55:46,440 --> 00:55:55,600
+وcirculating pool وعدّا هنشوفها mature form بتبدأ
+
+660
+00:55:55,600 --> 00:56:01,740
+الخلية أو الـ nucleus سلّها indentation و until
+
+661
+00:56:01,740 --> 00:56:04,280
+thin strand of membrane
+
+662
+00:56:10,160 --> 00:56:15,460
+اللي بتكون في النهاية وصلات ل-segments في داخل
+
+663
+00:56:15,460 --> 00:56:19,740
+الخلية يعني بتبدأ ال nucleus تتحول إلى segments
+
+664
+00:56:19,740 --> 00:56:24,400
+موصولة ب-filaments السبب في ذلك أنه في continuous
+
+665
+00:56:24,400 --> 00:56:30,420
+indentation لل nucleus وهذه خطوة من خطوات النضوج
+
+666
+00:56:30,420 --> 00:56:33,040
+عشان هيك الخلية في النهاية بيصير في multi
+
+667
+00:56:33,040 --> 00:56:38,440
+-segmented مظبوط وبيسموها poly يعني متعددة مورفل
+
+668
+00:56:38,440 --> 00:56:46,660
+نيوكلياربمعنى متعددة الأشكال many shaped nucleus و
+
+669
+00:56:46,660 --> 00:56:51,740
+بيسموها PMN cell is completely functional في هذه
+
+670
+00:56:51,740 --> 00:56:58,700
+المرحلة و ب spend time in the storage pool of the
+
+671
+00:56:58,700 --> 00:57:02,680
+bone marrow as well as the marginating and
+
+672
+00:57:02,680 --> 00:57:06,520
+circulating bone اللي عندنا هنشوفه تشكل خمسين
+
+673
+00:57:06,520 --> 00:57:11,470
+لسبعين في الميه من circulating white piecesبتقعد
+
+674
+00:57:11,470 --> 00:57:16,910
+وظيفة
+
+675
+00:57:16,910 --> 00:57:20,770
+الأساسية phagocytosis and pinocytosis بتعرف الفرق
+
+676
+00:57:20,770 --> 00:57:26,530
+بين التانين phagocytosis يعني بلع أكل ماشي بينما
+
+677
+00:57:26,530 --> 00:57:33,670
+ال pinocytosis يعني شرب ماشي pino يعني تشرب أو
+
+678
+00:57:33,670 --> 00:57:37,270
+المادة المبلوعة بتكون سائلة بينما هناك المادة اللي
+
+679
+00:57:37,270 --> 00:57:43,310
+مبلوعة بتكون صلبةيعنى phagocytosis involve large
+
+680
+00:57:43,310 --> 00:57:47,570
+material and can observe .. be observed with light
+
+681
+00:57:47,570 --> 00:57:51,930
+microscopy وإنما ال pinocytosis involve small
+
+682
+00:57:51,930 --> 00:57:55,690
+material بالبنبغوسي الليكويد و اللي بنشوفها
+
+683
+00:57:55,690 --> 00:58:02,050
+بالإلكترو مايكروسكوب الواضحتين هدولة يصيروا in
+
+684
+00:58:02,050 --> 00:58:07,170
+circulation و blood stream ينذفتشواطيب خلّينا نشوف
+
+685
+00:58:07,170 --> 00:58:11,130
+الكائنة تكسب نياترافيل و أن المراحل اللي بتمر فيها
+
+686
+00:58:11,130 --> 00:58:14,950
+ده هي من pluripotent stem cell تنتقل إلى مرحلة
+
+687
+00:58:14,950 --> 00:58:19,740
+ثانية هي progenitor cell ثمmorphologically
+
+688
+00:58:19,740 --> 00:58:24,400
+recognizable cell دي بدنا إيهاش انعرفها سنة نقول
+
+689
+00:58:24,400 --> 00:58:28,120
+myeloplastيبرون myelocyte ثم myelocyte ثم
+
+690
+00:58:28,120 --> 00:58:32,420
+metamyelocyte و band و segment العملية هذه بتاخد
+
+691
+00:58:32,420 --> 00:58:36,220
+لغاية الآن من ستة لعشر ايام بعدين بتطلع على ال
+
+692
+00:58:36,220 --> 00:58:38,400
+peripheral circulation في ال peripheral
+
+693
+00:58:38,400 --> 00:58:43,660
+circulation في عندنا two pool واحدة circulating
+
+694
+00:58:43,660 --> 00:58:46,760
+بمعنى ان white blood cell is circulating و dim
+
+695
+00:58:46,760 --> 00:58:51,490
+bloodوالتانية marginating بتكون الخلايا اللي هي
+
+696
+00:58:51,490 --> 00:58:55,450
+النيتروفي اللي ملزقة في جدار الوعاء الدموي بيسموها
+
+697
+00:58:55,450 --> 00:59:03,630
+marginating pool والتمتين بيحتووا على عدد متساوي
+
+698
+00:59:03,630 --> 00:59:09,370
+من الخلايا وزي ما انتوا شايفين السهم طالع نازل في
+
+699
+00:59:09,370 --> 00:59:14,150
+continuous exchange between marginating وbetween
+
+700
+00:59:14,150 --> 00:59:20,950
+circulatingوإنه احنا لما بنعد ال white pieces بنعد
+
+701
+00:59:20,950 --> 00:59:24,710
+نص ال white pieces اللي هي ال circulating white
+
+702
+00:59:24,710 --> 00:59:30,670
+pieces تبقى الخلية في ال peripheral blood من 6 ل
+
+703
+00:59:30,670 --> 00:59:37,080
+10 دقيقةإذا استدعيناها ل infection عشان تعمل عملية
+
+704
+00:59:37,080 --> 00:59:41,540
+قتل للميكروب phagocytosis فده هي راحت ما
+
+705
+00:59:41,540 --> 00:59:46,360
+استدعيناهاش بتموت بعد ما تنتهي العشرة بمعنى إذا
+
+706
+00:59:46,360 --> 00:59:50,920
+مافيش antigenات ال life span تبعتها بتنتهي ولاحظوا
+
+707
+00:59:50,920 --> 00:59:55,780
+حاجةاللي هو ال regulating factors زي ما انتوا
+
+708
+00:59:55,780 --> 00:59:59,820
+شايفين ال cytokine اللي فوق في مراحل معينة أدائية
+
+709
+00:59:59,820 --> 01:00:04,460
+المبكرة جدا stem cell factor ان الكو بيشتغل على ال
+
+710
+01:00:04,460 --> 01:00:09,380
+myeloblast فقط بيشاركوا في ذلك الآية التلاتة ثم
+
+711
+01:00:09,380 --> 01:00:14,580
+بيجي ال GMCSF بيشتغل على كل المراحل مين بيشاركوا
+
+712
+01:00:14,580 --> 01:00:19,960
+GCSF برضه بيشتغل على ايش على كل المراحل وهذا ما
+
+713
+01:00:19,960 --> 01:00:24,330
+يسمى بالkinetic ofاللي هو Neutrophil أو
+
+714
+01:00:24,330 --> 01:00:28,230
+Gramminocytes نوع
+
+715
+01:00:28,230 --> 01:00:31,330
+آخر من الخلايا وهو الـ monocytes اللي بدها تنتقل
+
+716
+01:00:31,330 --> 01:00:36,470
+إلى أو تتحول إلى ال macro fish monocyte macro fish
+
+717
+01:00:36,470 --> 01:00:43,350
+ال mature from monoblast to promonocyte بعد هي
+
+718
+01:00:43,350 --> 01:00:48,250
+بتروح على ال blood as monocyte ثم بعد ذلك بتهاجر
+
+719
+01:00:48,250 --> 01:00:54,490
+إلى ال tissue as إما freeيعني متحركة or fixed
+
+720
+01:00:54,490 --> 01:00:59,250
+macrophage لكن mechanism of commitment لغاية الآن
+
+721
+01:00:59,250 --> 01:01:05,410
+احنا مابنعرفش كيف بيتم عملية اختيار هذا الخط من
+
+722
+01:01:05,410 --> 01:01:10,730
+الإنتاج granular content vary considerably with
+
+723
+01:01:10,730 --> 01:01:15,680
+more than 50 secretorycompounds having been
+
+724
+01:01:15,680 --> 01:01:23,140
+identified يعني في أكتر من خمسين نوع من المركبات
+
+725
+01:01:23,140 --> 01:01:28,830
+موجودة في ال granules تبعتهابولي مورف بريفرال بلد
+
+726
+01:01:28,830 --> 01:01:34,070
+مونوسايت تشكل أشكال مختلفة تتشكل أشكال مختلفة وده
+
+727
+01:01:34,070 --> 01:01:37,890
+وضع طبيعي لإن الخلية لازالت immature يعني هي
+
+728
+01:01:37,890 --> 01:01:40,810
+الخلية الوحيدة اللي بتنزل من البرمارو على البرفرال
+
+729
+01:01:40,810 --> 01:01:44,830
+بلد as immature form إبعد ذلك بتتقلتش و هناك بصلة
+
+730
+01:01:44,830 --> 01:01:51,370
+maturation و بتتحول إلى ال macrophage مونوسايت ال
+
+731
+01:01:51,370 --> 01:01:57,970
+nucleus is intended نطوية or curvedيعني في انبعاج
+
+732
+01:01:57,970 --> 01:02:03,350
+فيها or cured و ال chromatin that is lazy و ال
+
+733
+01:02:03,350 --> 01:02:09,510
+small clumps lazy يعني ..يعني homogeneous فى شوية
+
+734
+01:02:09,510 --> 01:02:13,730
+تكتلات فيها typically the largest cell هي أكبر
+
+735
+01:02:13,730 --> 01:02:16,350
+الخلايا في ال peripheral blood و أرضه مرجى تانية
+
+736
+01:02:16,350 --> 01:02:22,870
+أكدلكوا لإنها immature عشان هي كبيرةالسيطوبلازم
+
+737
+01:02:22,870 --> 01:02:26,690
+مليئ بالميزة من الميزة المتوسطة التي تجعلها تبدو
+
+738
+01:02:26,690 --> 01:02:31,290
+مظلمة، مظلمة يعني زي الغيمة، السيطوبلازم بيكون
+
+739
+01:02:31,290 --> 01:02:38,190
+سيطوبلازمية ممبرينية ممكن تكون عادية، سودو بود،
+
+740
+01:02:38,190 --> 01:02:43,330
+وفاكوستيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكي
+
+741
+01:02:44,710 --> 01:02:46,970
+وهي المراحل بتمر فيها من الـ monoblast
+
+742
+01:02:46,970 --> 01:02:52,990
+لبرومونوسايتس وين موجود في ال bone marrow ثم بتنزل
+
+743
+01:02:52,990 --> 01:02:56,930
+على ال peripheral blood as monocyte و بتقعد من 3 ل
+
+744
+01:02:56,930 --> 01:03:00,190
+8 ساعات في ال peripheral blood ثم بتنتقل على ال
+
+745
+01:03:00,190 --> 01:03:04,230
+tissue كإما mature or macrophage ثم بيصير mature
+
+746
+01:03:04,230 --> 01:03:09,410
+or macrophage و قلتلكوا في نوعين إما free or fixed
+
+747
+01:03:12,550 --> 01:03:17,790
+أخر هذه الخلايا هي الـ lymphocytes the only human
+
+748
+01:03:17,790 --> 01:03:20,250
+white blood cell whose site of development is not
+
+749
+01:03:20,250 --> 01:03:23,950
+just bone marrow هو هي الخلية الوحيدة اللي ندوجها
+
+750
+01:03:23,950 --> 01:03:29,010
+أو نشوقة sorry ندوجها لا يتم في ال bone marrow
+
+751
+01:03:29,010 --> 01:03:38,970
+لحاله لكن tissue referred to as primary and
+
+752
+01:03:38,970 --> 01:03:42,960
+secondary lymphoid organs الآن هنشوفهإن ال primary
+
+753
+01:03:42,960 --> 01:03:46,120
+lymphoid organs كلنا بنعرف إن ال primary lymphoid
+
+754
+01:03:46,120 --> 01:03:50,880
+organs في الإنسان هي ال bone marrow و ال thymus
+
+755
+01:03:50,880 --> 01:03:55,300
+الخلق طبعا فيه أن other secondary طبعا فيه أن ال
+
+756
+01:03:55,300 --> 01:03:58,760
+lymph nodes و ال spleen و ال kiss patches و
+
+757
+01:03:58,760 --> 01:04:02,980
+الwaldemeier ring هذا خدته كله في ال anatomy كله
+
+758
+01:04:02,980 --> 01:04:07,190
+هذا عبارة عن secondary lymphoid organsالخلية ال
+
+759
+01:04:07,190 --> 01:04:12,030
+Infocyte بالمناسبة بتنشأ في ال bone marrow ثم في
+
+760
+01:04:12,030 --> 01:04:15,530
+مرحلة مبكرة جدا تنتقل من ال bone marrow و تروح
+
+761
+01:04:15,530 --> 01:04:21,230
+وين؟ على ال thymus اي نوع ال T cell ال B ليش بيصير
+
+762
+01:04:21,230 --> 01:04:24,890
+فيه؟ بيضل في ال bone marrow و يندرج في ال bone
+
+763
+01:04:24,890 --> 01:04:27,490
+marrow و يندرج في ايش؟ في ال bone marrowطبعا
+
+764
+01:04:27,490 --> 01:04:30,310
+التنتين متى ما ندجوا و طلعوا واحدة من البودمار و
+
+765
+01:04:30,310 --> 01:04:32,930
+واحدة من الثايمس بيروحوا على ال blood و من ال
+
+766
+01:04:32,930 --> 01:04:35,550
+blood بيروحوا على ال secondary lymphoid organs و
+
+767
+01:04:35,550 --> 01:04:40,690
+هناك بيحاربوا اللي هو ال antigen لأن وظيفتهم
+
+768
+01:04:40,690 --> 01:04:45,790
+مناعية ال lymphocytes circulate through the blood
+
+769
+01:04:45,790 --> 01:04:49,330
+و ال both peripheral blood ده كله توانة حكيتها لكم
+
+770
+01:04:49,330 --> 01:04:54,230
+إياها الخلايا ممكن تكون short lived or long lived
+
+771
+01:04:56,120 --> 01:04:59,460
+ممكن يكون عمرها الزمن يختلف، يتباين عمرها الزمن
+
+772
+01:04:59,460 --> 01:05:03,320
+الزمني، في خلايا بتفرزلي انتيبادي زي الـ B
+
+773
+01:05:03,320 --> 01:05:07,140
+-Lymphocyte وفي خلايا بتشتلأ الـ cell mediated من
+
+774
+01:05:07,140 --> 01:05:12,920
+خلال الريسبتور المعينة الـ pluripotential stem
+
+775
+01:05:12,920 --> 01:05:19,440
+cell، resultant stem cell for lymphoid cell، هي
+
+776
+01:05:19,440 --> 01:05:23,440
+colon forming unit لينفويد من المراحل، و ال colon
+
+777
+01:05:23,440 --> 01:05:26,020
+forming unit mature in several environments،
+
+778
+01:05:26,590 --> 01:05:34,870
+والتنالكو بيصير لها ندوج في ال primary للانفوض
+
+779
+01:05:34,870 --> 01:05:39,110
+organs وفي هذه المرحلة بيسموها antigen independent
+
+780
+01:05:39,110 --> 01:05:43,430
+يعني في غياب وجود ال antigen بيصير فيه ندوج لهذه
+
+781
+01:05:43,430 --> 01:05:50,810
+الخلايا تنزل بعدين على البرفرال بلد ونسبتها
+
+782
+01:05:50,810 --> 01:05:55,630
+بتختلف باختلاف العمرفي الأطفال على سبيل المثال في
+
+783
+01:05:55,630 --> 01:06:06,490
+عمر أربع سنوات الانفصاد بتكون عالية و بتعتبر the
+
+784
+01:06:06,490 --> 01:06:10,050
+second most common white species في البرفربلب
+
+785
+01:06:10,050 --> 01:06:16,840
+بتشكل من 20 ل 40% من ال white speciesعشرين لخمسة
+
+786
+01:06:16,840 --> 01:06:20,740
+.. عشرين لخمسة و تلاتين فمية من هذه الخلايا هي B
+
+787
+01:06:20,740 --> 01:06:25,160
+-lymphocyte والباقي هو T-lymphocytes المراحل اللي
+
+788
+01:06:25,160 --> 01:06:30,300
+بتمر فيها lymphoblasts to pro-lymphocytes
+
+789
+01:06:30,300 --> 01:06:35,640
+lymphoblast أصغرهم من عشر لتمنتاش round to oval
+
+790
+01:06:35,640 --> 01:06:39,920
+lose chromatin with one or more active nuclei
+
+791
+01:06:41,650 --> 01:06:47,730
+scanty يعني قليل الـ cytoplasm و الـ pro
+
+792
+01:06:47,730 --> 01:06:51,710
+lymphocytes difficult to distinguish عن ال
+
+793
+01:06:51,710 --> 01:06:59,710
+lymphocyte سبتل changes يعني اختلافات صعبة more
+
+794
+01:06:59,710 --> 01:07:04,170
+clumped chromatins lessening nuclear prominence
+
+795
+01:07:04,170 --> 01:07:09,460
+change in thickness of the nucleiوهي ال
+
+796
+01:07:09,460 --> 01:07:13,320
+lymphopoiesis هدا هي في ال bone marrow بتندج كل
+
+797
+01:07:13,320 --> 01:07:18,500
+الخلايا مع other cells ثم بتديني stem cell
+
+798
+01:07:18,500 --> 01:07:25,160
+lymphoid ماشي و هاد ال stem cell جزء منها بصير B
+
+799
+01:07:25,160 --> 01:07:30,060
+cell و جزء منها بصير T cell ال B cell برو بيه
+
+800
+01:07:30,060 --> 01:07:34,420
+بيندج ل بري بيه و بعدين بتطلع كأي mature بيه ثم
+
+801
+01:07:34,420 --> 01:07:39,470
+mature على البرفرالبلاد بينماالبروتي بتروح الـ
+
+802
+01:07:39,470 --> 01:07:43,990
+thymus و هناك بيصير في عملية مضوج إلىها و بتطلع
+
+803
+01:07:43,990 --> 01:07:48,770
+بعد هيك اما CD4 و اما CD8 البيسل تديني كل انواع
+
+804
+01:07:48,770 --> 01:07:52,810
+الانتيبادية دهية بينما التيسل فيه انه different
+
+805
+01:07:52,810 --> 01:07:58,090
+types of ash او تيسل اخر هذه الانواع هو
+
+806
+01:07:58,090 --> 01:08:05,060
+thrombopoiesis يعني إيش يعني إنتاج لـ plateletكيف
+
+807
+01:08:05,060 --> 01:08:11,460
+بتتم؟ قالوا هذه اختلاف كل عن الخلايا الأخرى، ماشي
+
+808
+01:08:11,460 --> 01:08:14,880
+أولاً الـplatelet وظيفتها الأساسية في الـprimary
+
+809
+01:08:14,880 --> 01:08:17,720
+hemostasis يعني التلتة العبدالجبير في عملية التجلب
+
+810
+01:08:17,720 --> 01:08:22,320
+ال life span تبعتها المنتج يعني من سبعة لعشر أيام
+
+811
+01:08:24,050 --> 01:08:29,170
+وغالبا بتنتج as if fragmented of cytoplasm من مين؟
+
+812
+01:08:29,170 --> 01:08:33,030
+من ال megakaryocytes يعني عبارة عن نطوئات عبارة عن
+
+813
+01:08:33,030 --> 01:08:39,670
+fragments من ال megakaryocyte cytoplasm و العملية
+
+814
+01:08:39,670 --> 01:08:46,550
+بتتم بطريقة مختلفة من الندوش قالوا اسموها
+
+815
+01:08:46,550 --> 01:08:50,830
+endomyotic replication process ايش يعني endomyotic
+
+816
+01:08:50,830 --> 01:08:55,190
+replication؟ ان الندوش داخليماشي اللي مصير قالوا
+
+817
+01:08:55,190 --> 01:09:02,070
+بتتك .. بتزيد مصير في replication لل DNA و بتبدأ
+
+818
+01:09:02,070 --> 01:09:13,280
+ال .. الخلية تكبر ماشي و ال cytoplasm يبدأ يكبرو
+
+819
+01:09:13,280 --> 01:09:19,380
+هدا هي زى ما انتوا شايفين بدت صغيرة ثم كبرت ماشي و
+
+820
+01:09:19,380 --> 01:09:23,420
+زى ما انتوا شايفين ال DNA بدأ بواحة ثم صارله
+
+821
+01:09:23,420 --> 01:09:28,480
+replication ماشي لكن بيصيرش انقسام للخلية بتضل
+
+822
+01:09:28,480 --> 01:09:33,400
+الخلية تكبر و ت .. و تكبر و ت .. لغاية ما .. هدا
+
+823
+01:09:33,400 --> 01:09:37,460
+هي زى ما انتوا شايفين كبرت كتيرتصل إلى مرحلة
+
+824
+01:09:37,460 --> 01:09:43,360
+بتنفجر هذه الخلية ويطلع منها مين؟ اللي هو
+
+825
+01:09:43,360 --> 01:09:47,260
+fragments of cytoplasm وهو اللي بنسميها
+
+826
+01:09:47,260 --> 01:09:52,780
+الـplatelet طبعا
+
+827
+01:09:52,780 --> 01:09:55,220
+الـplatelet بس تطلع الـperipheral blood طولتها
+
+828
+01:09:55,220 --> 01:09:58,340
+بيروح على الـspleen ويخزن في الـspleen as reserve
+
+829
+01:10:02,080 --> 01:10:05,020
+مين اللي مسؤول عنه؟ أولا هذه المراحل اللي بتمر
+
+830
+01:10:05,020 --> 01:10:08,800
+فيها هي stem cell ثم multipotent progenitor cell
+
+831
+01:10:08,800 --> 01:10:12,620
+ثم committed يعني التزمت megakaryocyte progenitor
+
+832
+01:10:12,620 --> 01:10:16,660
+cell ثم immature megakaryocyte ثم mature
+
+833
+01:10:16,660 --> 01:10:20,580
+megakaryocyte ومتى ما صارت mature بتنفجر و بتدنياش
+
+834
+01:10:20,580 --> 01:10:24,140
+ال platelet زي ما تشهد هي المراحل المختلفة اللي
+
+835
+01:10:24,140 --> 01:10:28,440
+بتمر فيها و هذه عبارة عن ال cytokine أو ال
+
+836
+01:10:28,440 --> 01:10:32,300
+regulators لكل مرحلة من المراحلزي ما تلاحظوا
+
+837
+01:10:32,300 --> 01:10:39,600
+thrombobiotin موجود في كل مرحلة من المراحل إيش دور
+
+838
+01:10:39,600 --> 01:10:44,560
+ال IL-1؟ قالوا ال IL-1 هذا cytokine مميز بيلعب دور
+
+839
+01:10:44,560 --> 01:10:50,900
+كبير في كل إنتاج معظم خلايا الجسم الإنسان، معظم
+
+840
+01:10:50,900 --> 01:10:55,040
+خلايا الجسم الإنسان، ماشي؟ فهي أشتغل دوة IL-1 من
+
+841
+01:10:55,040 --> 01:11:01,410
+.. ماشي؟داني telephocyte في وجودها يلوان، داني
+
+842
+01:11:01,410 --> 01:11:07,450
+encysal، داني neutrophil، داني muscle cell، داني
+
+843
+01:11:07,450 --> 01:11:12,330
+brain cell، و هكذا عشان هيك بيسموه the father of
+
+844
+01:11:12,330 --> 01:11:19,770
+cytokine طيب ال summary أرجو أن تكونوا يعني
+
+845
+01:11:19,770 --> 01:11:24,600
+تابعتوا معايا متابعةجيدة و خلّينا نعمل تلخيص لعيش
+
+846
+01:11:24,600 --> 01:11:28,460
+لهذه المخادرة normal hemopause is necessary for
+
+847
+01:11:28,460 --> 01:11:33,000
+survival طبيعي جدا ضروري for survival وإلا بدون
+
+848
+01:11:33,000 --> 01:11:37,060
+خلايا احنا ما بيصير فيه حياة it's under the
+
+849
+01:11:37,060 --> 01:11:39,980
+control of multiple factors شوفنا العوامل المختلفة
+
+850
+01:11:39,980 --> 01:11:44,120
+اللي بتعيش بتتحكم في هذه العملية normal bone
+
+851
+01:11:44,120 --> 01:11:46,980
+marrow environment is necessary الها normal bone
+
+852
+01:11:46,980 --> 01:11:51,900
+.. الها micro environment خاصة فيها ولا لأ؟ثم
+
+853
+01:11:51,900 --> 01:11:56,100
+Decrease production results in cytopenia مافيش
+
+854
+01:11:56,100 --> 01:11:59,620
+إنتاج بيصير فيه قلة فيه إيش فيه عدد الخلايا
+
+855
+01:11:59,620 --> 01:12:05,740
+بيسموها cyto يعني خلية و penia قلة ماشي cytopenia
+
+856
+01:12:05,740 --> 01:12:14,180
+وهي ال hemopoietic ماشي characteristic feature فقط
+
+857
+01:12:14,180 --> 01:12:19,560
+تلاحظ الإختلافات ماشي المختلفة
+
+858
+01:12:23,880 --> 01:12:27,700
+بتكون غير نادجة، بتكون كبيرة، و لما بتنضج، بتصغر.
+
+859
+01:12:29,000 --> 01:12:32,100
+لما بتكون غير نادجة، بيكون الـcytoplasm كبير و
+
+860
+01:12:32,100 --> 01:12:37,400
+أزرق، لما بيتنضج، بيقل، و في نفس الوقت بيتحول لونه
+
+861
+01:12:37,400 --> 01:12:41,980
+إلى لون بنكرة، عسم الـMetal في العرب السيطر. ماشي؟
+
+862
+01:12:41,980 --> 01:12:45,920
+مرت في أكتر من مرحلة، مراحل كثيرة. في مراحل مبكرة،
+
+863
+01:12:45,920 --> 01:12:50,080
+بيكون فيه الـnucleus و الـnucleoliفي مراحل مختلفة،
+
+864
+01:12:50,080 --> 01:12:53,500
+هي راحت الـNucleus من أصله بالنسبة للـRBC وها كذا
+
+865
+01:12:53,500 --> 01:12:57,500
+كل ما نضجت الخلية اختلفت في الـsize اختلفت في
+
+866
+01:12:57,500 --> 01:13:01,520
+الـnucleus shape اختلفت في الـcytoplasm content
+
+867
+01:13:01,520 --> 01:13:08,340
+and shape ودوم الاختلافات one by one هي كانت large
+
+868
+01:13:08,340 --> 01:13:13,260
+وصارت صغيرة الـnucleoli كانت موجودة بطلت
+
+869
+01:13:13,260 --> 01:13:16,200
+الـnucleus سورياني
+
+870
+01:13:20,100 --> 01:13:25,620
+Disappear.Cytoplasm thinning كان دي بفلوسار اللي
+
+871
+01:13:25,620 --> 01:13:31,760
+هو various color حسب نوع الخلية.Formation of
+
+872
+01:13:31,760 --> 01:13:35,260
+granules بيكون أول شي ليسي ثم بيصير فيه condensed.
+
+873
+01:13:36,400 --> 01:13:41,500
+Mitosis بيكون عالي وبدأش ال mitotic activity يتقل.
+
+874
+01:13:44,270 --> 01:13:48,390
+monophyletic theory of cell formation هذه النظريات
+
+875
+01:13:48,390 --> 01:13:53,570
+اللي حطوها لعملية ال hemopoiesis قالوا فيها انها
+
+876
+01:13:53,570 --> 01:14:00,710
+monophyletic وضعيفلتك ثم اللي هو tri او poly
+
+877
+01:14:00,710 --> 01:14:05,310
+monophyletic theory ايش بتقول؟ بتقول ان كل الخلايا
+
+878
+01:14:05,310 --> 01:14:09,870
+هذه أساسها خلية واحد وهي ال stem cell طبعا لما
+
+879
+01:14:09,870 --> 01:14:13,720
+بتحكي على ضعيفلتك بتحكي على خليتينكل الخلايا
+
+880
+01:14:13,720 --> 01:14:20,560
+أساسهم خاليتين ماشي لكن أكتر النظريات شيوعا و
+
+881
+01:14:20,560 --> 01:14:24,480
+تقبلا هي هذه النظرية وهي ال monophoretic theory أن
+
+882
+01:14:24,480 --> 01:14:28,160
+كل الخلايا أساسها خلية واحدة هي الاستمثال زي ما
+
+883
+01:14:28,160 --> 01:14:32,220
+شرحنا تدينا خالتين monomyloid وليكفويد وكل واحدة
+
+884
+01:14:32,220 --> 01:14:39,080
+بتدينا خلايا مختلفة حسب النوع أتمنى لكم ان شاء
+
+885
+01:14:39,080 --> 01:14:45,570
+اللهال .. أن تكونوا قد استمتعتوا في هذه المحاضرة و
+
+886
+01:14:45,570 --> 01:14:51,350
+أن تكونوا تابعتوني واستوعبتم المحاضرة المحاضرة
+
+887
+01:14:51,350 --> 01:14:58,770
+سهلة فقد تحتاج إلى المراجعة و المراجعة الفورية ما
+
+888
+01:14:58,770 --> 01:15:01,610
+بنفع نسيبها فترة معينة و شكرا
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w.srt
new file mode 100644
index 0000000000000000000000000000000000000000..6ede2cfccb36640f0449cbd26414eccc0343ff65
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w.srt
@@ -0,0 +1,2055 @@
+1
+00:00:01,650 --> 00:00:05,710
+بسم الله الرحمن الرحيم استكمالا لموضوع ال-acute
+
+2
+00:00:05,710 --> 00:00:09,810
+leukemia كنا قد وصلنا إلى ال-acute myeloid
+
+3
+00:00:09,810 --> 00:00:15,530
+leukemia واللي قلنا كمان بتسمى acute granulocytic 
+
+4
+00:00:15,530 --> 00:00:20,630
+leukemia تقسمها إلى 8 أنواع زي ما اتفقنا والـ
+
+5
+00:00:20,630 --> 00:00:26,010
+classification بيعتمد على الآتي: نمرة واحد الـ bone
+
+6
+00:00:26,010 --> 00:00:29,610
+marrow blast morphology  morphology of the cell نمرة
+
+7
+00:00:29,610 --> 00:00:34,190
+اثنين degree of cell maturation يعني لوين وصلت
+
+8
+00:00:34,190 --> 00:00:37,890
+الخلية في الـ maturation نمرة ثلاثة cytochemical
+
+9
+00:00:37,890 --> 00:00:41,730
+staining عشان نحدد which type من التمانية اللي
+
+10
+00:00:41,730 --> 00:00:48,150
+موجودين نمرة أربع immune و phenotyping ونمرة خمسة
+
+11
+00:00:48,150 --> 00:00:52,900
+إن شاء الله هنحكي في cytogenetic زي ما اتفقنا
+
+12
+00:00:52,900 --> 00:00:57,720
+قسموها إلى هن سبع أنواع ثم أضافوا النوع الثامن وهو
+
+13
+00:00:57,720 --> 00:01:02,820
+M0 هن بديل من M1 والـ M1 اللي هي without
+
+14
+00:01:02,820 --> 00:01:10,120
+maturation myeloplastic cell without maturation
+
+15
+00:01:10,120 --> 00:01:16,380
+بمعنى أنه مافي اللي هو التسلسل نضوج الخلية كل
+
+16
+00:01:16,380 --> 00:01:19,880
+اللي بنشوفه هو عبارة عن أكثر من تسعين في المئة من
+
+17
+00:01:19,880 --> 00:01:24,900
+الـ blast  وأقل من عشرة في المئة الـ promyelocyte اللي
+
+18
+00:01:24,900 --> 00:01:30,120
+هي المرحلة التي تليها وغالبا مرض الـ acute
+
+19
+00:01:30,120 --> 00:01:35,680
+leukemia of this type بيصيب الناس اللي هو الـ all
+
+20
+00:01:35,680 --> 00:01:36,180
+people
+
+21
+00:01:45,040 --> 00:01:51,560
+الشكل myeloblast زي ما أنتم شايفين هي خلية
+
+22
+00:01:51,560 --> 00:01:58,000
+كبيرة فيها nucleus مخ ده حجم كبير وفيها
+
+23
+00:01:58,000 --> 00:02:03,660
+nucleoli هذه واضحة nucleoli هي واحدة وهنا
+
+24
+00:02:03,660 --> 00:02:09,030
+واضحة ماشي وإن كان في بعض الأحيان داكنة لكنها
+
+25
+00:02:09,030 --> 00:02:14,730
+واضحة عن أي وضوح من جلي فيها زي ما اتفقنا الـ
+
+26
+00:02:14,730 --> 00:02:20,570
+chromatin material is homogeneous مش واضح لساته
+
+27
+00:02:20,570 --> 00:02:33,100
+soft وفيها الـ cytoplasm تقريبا قليل ده هو فيها
+
+28
+00:02:33,100 --> 00:02:36,480
+few or root body لأن هذه عبارة عن الـ granulocytic
+
+29
+00:02:36,480 --> 00:02:40,200
+والـ few or root body هي عبارة عن الـ alignments of
+
+30
+00:02:40,200 --> 00:02:44,160
+primary granules  مصرية في داخل الخلية هي الـ few
+
+31
+00:02:44,160 --> 00:02:47,560
+or root body يعني هذا ما يميز الـ myeloplast عن الـ
+
+32
+00:02:47,560 --> 00:02:53,960
+lymphoplast اللي شفناها قبل هيك M2 مصير فيها
+
+33
+00:02:53,960 --> 00:03:01,390
+maturation يعني بنشوف فيه أكثر من نوع من أكثر من
+
+34
+00:03:01,390 --> 00:03:06,950
+مرحلة من مراحل نضوج الخلية هي فيها حوالي ثلاثين
+
+35
+00:03:06,950 --> 00:03:10,250
+لتسعة وتمانين أو تسعين plus في المئة أو أكثر من
+
+36
+00:03:10,250 --> 00:03:14,810
+عشرة في المئة promyelocytes
+
+37
+00:03:14,810 --> 00:03:19,850
+وهو بتميز بوجود أداة cytogenetic هذا اللي هو
+
+38
+00:03:19,850 --> 00:03:22,990
+chromosome of abnormality أو translocation ما بين
+
+39
+00:03:22,990 --> 00:03:27,960
+ثمانية وواحد وعشرين هذا موجود في كروموسوم الـ
+
+40
+00:03:27,960 --> 00:03:31,200
+normality اتفقنا أنه موجود في كل أنواع اللوكيميا
+
+41
+00:03:31,200 --> 00:03:38,200
+تقريبا بيصيب الناس الاختيارية برضه M3 في منها
+
+42
+00:03:38,200 --> 00:03:45,900
+نوعين hypergranular promyelocytic leukemia وأيضا
+
+43
+00:03:45,900 --> 00:03:53,620
+نشوف فيه أكثر من 30% blast وهذا مرض virulent than
+
+44
+00:03:53,620 --> 00:03:59,380
+other form يعني شرس زيادة أكثر من النوع الثاني
+
+45
+00:03:59,380 --> 00:04:04,520
+اللي هو الـ hypo بيصيب طبعا الناس اللي الـ median
+
+46
+00:04:04,520 --> 00:04:11,600
+age تسعة وثلاثين سنة والـ white blood cell بتقل وعلاجه
+
+47
+00:04:11,600 --> 00:04:17,800
+غالبا treatment بيؤدي إلى الـ release of granules
+
+48
+00:04:18,790 --> 00:04:23,970
+وهذا بيدخل المريض في حاجة بيسموها Disseminated
+
+49
+00:04:23,970 --> 00:04:29,390
+Intravascular Coagulopathy وطبعا يتبع ذلك الـ
+
+50
+00:04:29,390 --> 00:04:34,650
+bleeding يتبعه محصلته bleeding لأنه يبدأ هذا
+
+51
+00:04:34,650 --> 00:04:42,770
+المرض الـ DIC بجلطة ينتهي بنصف ما
+
+52
+00:04:42,770 --> 00:04:47,090
+يميز الـ M3 هو وجود Translocation ما بين 15 و 17
+
+53
+00:04:48,930 --> 00:04:57,330
+وهذه صورة الـ M2 اللي هي شفناها الـ myeloplast والـ
+
+54
+00:04:57,330 --> 00:05:04,690
+لي هي myeloplast بالمناسبة دي myeloplast والـ
+
+55
+00:05:04,690 --> 00:05:10,510
+promyelocytes اللي هي أكبر من الـ أش من الـ myeloplast
+
+56
+00:05:10,510 --> 00:05:15,230
+لكن هدول التانتين myeloplast
+
+57
+00:05:17,090 --> 00:05:21,090
+hypogranulated بمعنى أن لساتها والـ granules لم تظهر
+
+58
+00:05:21,090 --> 00:05:27,490
+بعد طبعا هذا blood film نتوقع فيه وجود mature
+
+59
+00:05:27,490 --> 00:05:30,750
+cells بالإضافة إلى الـ immature cells اللي هي اللي
+
+60
+00:05:30,750 --> 00:05:37,750
+موجودة أما ثلاثة اللي يقول hypergranular زي ما
+
+61
+00:05:37,750 --> 00:05:42,940
+أنتم شايفين في أن الـ cytoplasm is granulated ده
+
+62
+00:05:42,940 --> 00:05:47,800
+هو دي عبارة عن promyelocytes granulated برضه
+
+63
+00:05:47,800 --> 00:05:53,080
+granulated ماشي خلية كبيرة nucleus still have
+
+64
+00:05:53,080 --> 00:05:59,040
+nucleus to cytoplasm ratio still high لكن زي ما
+
+65
+00:05:59,040 --> 00:06:05,560
+أنتم شايفين الـ granules واضحة جدا في الخلية
+
+66
+00:06:08,600 --> 00:06:15,460
+أو ثلاثة M أو micro بيسموها أو hypo granular pro
+
+67
+00:06:15,460 --> 00:06:19,540
+myelocytic leukemia بنشوف فيها أكثر من ثلاثين فرمية
+
+68
+00:06:19,540 --> 00:06:27,000
+blast ونوع الـ blood cell بتزيد هناك بتقل وزي الـ
+
+69
+00:06:27,000 --> 00:06:33,810
+hyper granular التعامل يؤدي إلى DIC يدخل المريض في
+
+70
+00:06:33,810 --> 00:06:41,230
+DIC وبرضه يحصل فيه subsequent bleeding ويتميز
+
+71
+00:06:41,230 --> 00:06:47,330
+بوجود Translocation 15-17 تقريبا زي كل ما هناك شكل
+
+72
+00:06:47,330 --> 00:06:52,990
+الخلية تكون high و granulated M4 اللي هو
+
+73
+00:06:52,990 --> 00:06:59,590
+myelomonoplastic من الاسم myeloblast و monoblast
+
+74
+00:07:01,700 --> 00:07:07,800
+بشكل كم بورمارو وميرفرال بلد بيصير بيتميز الـ
+
+75
+00:07:07,800 --> 00:07:14,040
+M4 أنه بعد مرات بيصير فيه extramedullary site is
+
+76
+00:07:14,040 --> 00:07:18,620
+involved وفي هذا النوع بالذات it's more common
+
+77
+00:07:18,620 --> 00:07:28,940
+أكثر من الـ pure myeloplastic variants أي شكل M3
+
+78
+00:07:31,370 --> 00:07:39,410
+hypo granulated زي ما أنتم شايفين قنفور
+
+79
+00:07:39,410 --> 00:07:46,270
+فيه monoblast بالإضافة إلى myeloplast طبعا هذه كل
+
+80
+00:07:46,270 --> 00:07:49,330
+الأشكال اللي احنا شايفينها هي عبارة عن monoblast
+
+81
+00:07:49,330 --> 00:07:53,190
+هي زي ما أنتم شايفين monoblast هي خلية بتنقسم
+
+82
+00:07:53,190 --> 00:07:57,910
+أثناء انقسامها monoblast and nucleoli خلية كبيرة
+
+83
+00:07:57,910 --> 00:07:59,550
+جدا ماشي
+
+84
+00:08:05,190 --> 00:08:11,350
+M5 monoblastic leukemia أكثر من قسمناها لنوعين
+
+85
+00:08:11,350 --> 00:08:18,890
+قلنا اللي هو M5A و M5B أكثر من ثمانية في المئة of
+
+86
+00:08:18,890 --> 00:08:21,690
+non erythroid cell in the bone marrow are
+
+87
+00:08:21,690 --> 00:08:29,930
+monocytic وبيحصل فيه extensive infiltration بتغزو
+
+88
+00:08:29,930 --> 00:08:34,120
+الخلية السرطانية الـ gum والـ Central Nervous
+
+89
+00:08:34,120 --> 00:08:39,340
+System والـ lymph nodes وأكثر ومواقع أخرى أكثر
+
+90
+00:08:39,340 --> 00:08:46,860
+مدالة يعني تهاجر إلى أماكن غريبة غير متوقعة زي ما
+
+91
+00:08:46,860 --> 00:08:50,400
+جهزنا واتفقنا قسمنا إلى M5A اللي هو Poorly
+
+92
+00:08:50,400 --> 00:08:55,260
+Differentiated كل اللي موجود monoblast و M5B Well
+
+93
+00:08:55,260 --> 00:09:02,450
+Differentiated في monoblast وفي myeloblast  أمستكس
+
+94
+00:09:02,450 --> 00:09:11,690
+اللي هي الـ erythroleukemia this is rare لكنه يتميز
+
+95
+00:09:11,690 --> 00:09:16,550
+بوجود الـ erythroblast وقسموها
+
+96
+00:09:16,550 --> 00:09:24,170
+إلى ثلاثة different phases a preponderance of
+
+97
+00:09:24,170 --> 00:09:33,030
+abnormal erythroblast يعني سائد ثم erythroleukemia وفي
+
+98
+00:09:33,030 --> 00:09:35,350
+هذه اللي بيكون فيها erythroblast و monoblast و
+
+99
+00:09:35,350 --> 00:09:39,550
+myeloblast يعني الأولاني preparedness of abnormal
+
+100
+00:09:39,550 --> 00:09:42,710
+erythroblast كل اللي موجود erythroblast النوع
+
+101
+00:09:42,710 --> 00:09:46,810
+الثاني erythroleukemia بيكون فيه both erythroblast
+
+102
+00:09:46,810 --> 00:09:50,710
+و myeloblast والنوع الثالث myeloplastic leukemia
+
+103
+00:09:50,710 --> 00:09:57,430
+بتشبه M1 و M2 و M4 طبعا
+
+104
+00:09:57,430 --> 00:10:03,730
+في هذا النوع الـ English is common M5A monoblast
+
+105
+00:10:03,730 --> 00:10:09,710
+M5A
+
+106
+00:10:09,710 --> 00:10:14,970
+monoblast M5A monoblast M5A monoblast M5A monoblast 
+
+107
+00:10:14,970 --> 00:10:15,170
+M5A monoblast M5A monoblast M5A monoblast
+
+108
+00:10:15,170 --> 00:10:15,250
+M5A monoblast M5A monoblast M5A monoblast
+
+109
+00:10:15,250 --> 00:10:15,270
+M5A monoblast M5A monoblast M5A monoblast
+
+110
+00:10:15,270 --> 00:10:15,730
+M5A monoblast M5A monoblast M5A monoblast M5A 
+
+111
+00:10:15,730 --> 00:10:26,530
+monoblast M5A monoblast M5A monoblast M5A
+
+112
+00:10:26,530 --> 00:10:26,610
+monoblast 
+
+113
+00:10:30,200 --> 00:10:43,000
+مش شايفين فيه erythroblast واضحة ماشي وهذه أنه
+
+114
+00:10:43,000 --> 00:10:51,480
+أيضا erythroblast أو
+
+115
+00:10:51,480 --> 00:10:57,420
+سبعة ميجا كاريو ستة كلور كيميا هي عبارة عن ريل لكنه
+
+116
+00:10:57,420 --> 00:10:59,960
+يكون فيها extensive proliferation of 
+
+117
+00:10:59,960 --> 00:11:05,480
+megakaryoblast وبنشوف ايه الـ typical megakaryocyte
+
+118
+00:11:05,480 --> 00:11:10,400
+and thrombocytopenia هذا النوع السابق
+
+119
+00:11:13,580 --> 00:11:19,320
+احنا اتفقنا على أنه الـ classification بيعتمد على
+
+120
+00:11:19,320 --> 00:11:24,960
+أكثر من أيهاش من شغلها أول شغلها جلدها اللي هو الـ
+
+121
+00:11:25,920 --> 00:11:28,860
+blast morphology واتعرفنا على الـ morphological
+
+122
+00:11:28,860 --> 00:11:33,240
+differences between اللي هو different type of
+
+123
+00:11:33,240 --> 00:11:38,280
+acute myelogenous leukemia ومن العامل الآخر اللي
+
+124
+00:11:38,280 --> 00:11:41,920
+بيعتمد عليه الـ classification هو الـ cytochemistry
+
+125
+00:11:41,920 --> 00:11:45,660
+والـ cytochemistry من اسم cytochemistry بنستخدم
+
+126
+00:11:45,660 --> 00:11:51,560
+فيه chemical staining for staining the myeloid the
+
+127
+00:11:51,560 --> 00:11:57,040
+blast cell ومن خلال الـ study بنقدر نفرق between
+
+128
+00:11:57,040 --> 00:12:00,240
+different types of ash of leukemia وجاءوا
+
+129
+00:12:00,240 --> 00:12:05,340
+باستخدام هذا النوع أكثر من 70% من الحالات أو هذه
+
+130
+00:12:05,340 --> 00:12:10,580
+الأداة التشخيصية أكثر من 70% مع الـ morphology من
+
+131
+00:12:10,580 --> 00:12:14,580
+الـ leukemia can be classified
+
+132
+00:12:15,480 --> 00:12:20,600
+ومن أشهر الـ specialists تين اللي بتستخدم هي صبغات
+
+133
+00:12:20,600 --> 00:12:24,700
+بنصبغ فيها اللي هو أما الانزيمات اللي موجودة في
+
+134
+00:12:24,700 --> 00:12:30,000
+داخل الخلية وأما الـ granules اللي موجودة أشهر هذه
+
+135
+00:12:30,000 --> 00:12:36,260
+الصبغات هو أول اثنين الـ myeloperoxidase والسوداني
+
+136
+00:12:36,260 --> 00:12:43,250
+بلاك اللي بيفرقوا شعر ليه بين الـ acute
+
+137
+00:12:43,250 --> 00:12:46,410
+lymphoplastic leukemia والـ acute myeloplastic
+
+138
+00:12:46,410 --> 00:12:51,830
+leukemia استخدامهم they are negative في الـ acute
+
+139
+00:12:51,830 --> 00:12:57,230
+lymphoplastic leukemia و positive في الـ acute
+
+140
+00:12:57,230 --> 00:13:01,640
+myelogenous leukemia النوع الثاني هي specific for
+
+141
+00:13:01,640 --> 00:13:07,020
+a special type of AML
+
+142
+00:13:07,020 --> 00:13:12,800
+زي الـ non specific esterase اللي بيسبقنا في الـ M4 M5
+
+143
+00:13:12,800 --> 00:13:17,140
+it's positive in M4 M5 و الـ PAS او periodic acid
+
+144
+00:13:17,140 --> 00:13:22,880
+shift اللي بيسبق أو بدينا positive في الـ common
+
+145
+00:13:22,880 --> 00:13:28,460
+acute lymphoplastic leukemia و في الـ M6 في
+
+146
+00:13:28,460 --> 00:13:35,120
+الـ myeloid والـ اسد فوسفاتيز اللي هو specific for TALL
+
+147
+00:13:35,120 --> 00:13:40,300
+اللي هو T acute lymphoplastic leukemia ويبقى أيضا 
+
+148
+00:13:40,300 --> 00:13:46,460
+بـ plugs positive في الـ M6 الأداء
+
+149
+00:13:46,460 --> 00:13:50,040
+الثالثة اللي تعتمد عليها الـ classification وهي
+
+150
+00:13:50,040 --> 00:13:58,040
+أداءتعتمد على الـ immunological reaction ماشي
+
+151
+00:13:58,040 --> 00:14:05,360
+باستخدام اللي هو سموها immunophenotyping وغالبا
+
+152
+00:14:05,360 --> 00:14:08,840
+هذه بتستخدم for lymphocytes
+
+153
+00:14:10,940 --> 00:14:17,040
+عشان نفرق ما بين الـ B و T cell lineage وزي ما
+
+154
+00:14:17,040 --> 00:14:22,660
+اتكلمتلكوا في المحاضرة السابقة أنه بنستخدم فيها
+
+155
+00:14:22,660 --> 00:14:31,320
+monoclonal antibody against surface marker وغالبا
+
+156
+00:14:31,320 --> 00:14:36,880
+طبعا التقنية اما بيكون by using primary antibody
+
+157
+00:14:36,880 --> 00:14:42,830
+directly or indirectly بغض النظر عن اللي هو الـ
+
+158
+00:14:42,830 --> 00:14:47,710
+technique أن هو احنا بنستخدم اما direct anti
+
+159
+00:14:47,710 --> 00:14:50,070
+-fluorescent antibody اللي بيدينا positive بعمل
+
+160
+00:14:50,070 --> 00:14:55,970
+fluoresce أو indirect اللي هو by using anti
+
+161
+00:14:55,970 --> 00:15:00,150
+-antibody اللي بيدينا برضه positive for cell
+
+162
+00:15:00,150 --> 00:15:05,570
+surface marker طبعا بعد هي كانت الـ fluorescent antibody
+
+163
+00:15:05,570 --> 00:15:16,650
+الـ antibody اللي بيدينا fluorescent dye can
+
+164
+00:15:16,650 --> 00:15:20,910
+be seen by fluorescent microscope or by using flow
+
+165
+00:15:20,910 --> 00:15:25,810
+cytometer طبعا من نخشش الخلايا على laser beam و هناك
+
+166
+00:15:25,810 --> 00:15:31,330
+بتبدأ تعدلنا اللي هو الـ fluorescent by by tagging
+
+167
+00:15:31,330 --> 00:15:35,230
+يعني ايش tagging يعني بتعد بتـ tag tag الخلايا
+
+168
+00:15:35,230 --> 00:15:40,090
+واحدة ورا التانية for positive or for the presence
+
+169
+00:15:40,090 --> 00:15:46,950
+of surface marker وهي
+
+170
+00:15:46,950 --> 00:15:53,260
+techniques اما direct antibody by using antibody
+
+171
+00:15:53,260 --> 00:15:59,140
+فلوريسابت انتيبادي فلورينايت انتيبادي فلوريسابت
+
+172
+00:15:59,140 --> 00:15:59,420
+انتيبادي فلورينايت انتيبادي فلوريسابت انتيبادي
+
+173
+00:15:59,420 --> 00:16:00,240
+انتيبادي فلوريسابت انتيبادي فلوريسابت انتيبادي
+
+174
+00:16:00,240 --> 00:16:03,000
+فلوريسابت انتيبادي فلوريسابت انتيبادي فلوريسابت
+
+175
+00:16:03,000 --> 00:16:05,000
+انتيبادي فلوريسابت انتيبادي فلوريسابت انتيبادي
+
+176
+00:16:05,000 --> 00:16:09,360
+فلوريسابت انتيبادي فلوريسابت انتيبادي فلوريسابت
+
+177
+00:16:09,360 --> 00:16:14,270
+انتيبادي فلوريسابالـ Anti-antibody اللي هو Anti
+
+178
+00:16:14,270 --> 00:16:18,490
+-mouse Anti-body اللي هو بيسموه secondary antibody
+
+179
+00:16:18,490 --> 00:16:23,250
+و الـ secondary هو اللي بيكون عيش بيكون fluorinated
+
+180
+00:16:23,250 --> 00:16:28,070
+ماشي طبعا ليش بنستخدم واحدة من التانتين؟ قالوا
+
+181
+00:16:28,070 --> 00:16:31,690
+الثانية is more specific وبالتالي it's more
+
+182
+00:16:31,690 --> 00:16:32,150
+accurate
+
+183
+00:16:35,020 --> 00:16:39,820
+أي فلوريسنت فلوريسيتوميتر طبعا زي ما أنتم شايفين
+
+184
+00:16:39,820 --> 00:16:49,420
+بنخشش الخلايا through a pore فتحة ماشي by cell by
+
+185
+00:16:49,420 --> 00:16:54,640
+cell يعني single cell بتمر عليش على laser beam بيه
+
+186
+00:16:54,640 --> 00:16:59,540
+مدينة في الآخر و الـ laser بيصير يعدلنا بنقطع و كل
+
+187
+00:16:59,540 --> 00:17:07,120
+ما نقطع كل ما ايش كل مادةاللي هو إشارة يعني بيعد
+
+188
+00:17:07,120 --> 00:17:10,360
+بنعد الإشارات وهذه الإشارات بيكون عادة الخلايا
+
+189
+00:17:10,360 --> 00:17:17,460
+اللي على سطحها positive او fluorescent dye اللي هو
+
+190
+00:17:17,460 --> 00:17:24,080
+احنا قصدنا نعده مثال
+
+191
+00:17:24,080 --> 00:17:26,960
+على الـ fluorescent او الـ flow cytometry اللي هو
+
+192
+00:17:26,960 --> 00:17:30,620
+قياسنا للـ terminal deoxy transferase هذا عبارة عن
+
+193
+00:17:30,620 --> 00:17:34,360
+إنزيم يونيك دي ان اي بولي ماريز موجود في الـ stem
+
+194
+00:17:34,360 --> 00:17:39,760
+cell او الـ precursor cell of both B and T
+
+195
+00:17:44,560 --> 00:17:48,640
+لأن الـ Lymphoplasts و Lymphoplastic Leukemia أكثر
+
+196
+00:17:48,640 --> 00:17:53,860
+من 90% من الحالات بيكون أن هي positive و أيضا we
+
+197
+00:17:53,860 --> 00:17:58,960
+can use we can detect it by using appropriate
+
+198
+00:17:58,960 --> 00:18:04,600
+antibody on a flow cytometry قسموا
+
+199
+00:18:04,600 --> 00:18:11,200
+الخلايا according to immunological approach اللي
+
+200
+00:18:11,200 --> 00:18:17,290
+توي حاكينا عليه إلى الآتي كان الـ acute myeloid
+
+201
+00:18:17,290 --> 00:18:20,970
+leukemia ماشي
+
+202
+00:18:20,970 --> 00:18:26,750
+على سطحها الـ myeloblast بيكون على سطحها CD13
+
+203
+00:18:26,750 --> 00:18:34,030
+positive و CD33 positive و TDT negative وقولنا لكم
+
+204
+00:18:34,030 --> 00:18:40,220
+الـ CD يعني cluster of differentiation رقم تلاتاش
+
+205
+00:18:40,220 --> 00:18:44,960
+يعني رقم الـ Monoclonal Antibody اللي رطق الاتفاعل
+
+206
+00:18:44,960 --> 00:18:53,020
+مع الـ molecule المعين اللي على سطح الخلايا وهذه
+
+207
+00:18:53,020 --> 00:18:58,540
+بتفرق بين الـ different types of cell من خلال هذه
+
+208
+00:18:58,540 --> 00:19:02,640
+التكنيك احنا بنفرق between different types of ايش
+
+209
+00:19:02,640 --> 00:19:07,760
+عشان هيك بيسموه numerical technique هو عبارة عن
+
+210
+00:19:07,760 --> 00:19:14,220
+نظام تسمية مفرز من خلاله الأنواع المختلفة من
+
+211
+00:19:14,220 --> 00:19:14,920
+الخلايا
+
+212
+00:19:17,660 --> 00:19:20,980
+اللي هو الـ Myeloplast مشان الفرق بينه و بين الـ
+
+213
+00:19:20,980 --> 00:19:24,340
+lymphoplast زي ما شوفنا كانوا الـ myeloplast بيكون
+
+214
+00:19:24,340 --> 00:19:30,280
+على سطحه CD13 positive و بيكون عندها CD33 positive
+
+215
+00:19:30,280 --> 00:19:34,040
+و بيكون عندها الـ TDT دوهو تيرمينال ديوكسي
+
+216
+00:19:34,040 --> 00:19:38,180
+رايبونيوهليوتايديل ترانسفريز انزيم نيجاتيف لأن كل
+
+217
+00:19:38,180 --> 00:19:43,540
+هذا الانزيم بيكون موجود في الـ lymphoplast مش في
+
+218
+00:19:43,540 --> 00:19:50,470
+الـ myeloplast أيضا وجدوا أنه فيه special antibody
+
+219
+00:19:50,470 --> 00:19:55,890
+can be used for M6 و M7 فقالوا الـ M6 فيه على سطحها
+
+220
+00:19:55,890 --> 00:20:00,530
+بيكون glycoporin A positive و الـ glycoporin A هذا
+
+221
+00:20:00,530 --> 00:20:04,630
+عبارة عن الـ antigen تبع الـ blood group اللي موجودة
+
+222
+00:20:04,630 --> 00:20:09,930
+على سطح الخلايا still بيكون positive و M7 بيكون
+
+223
+00:20:09,930 --> 00:20:16,980
+على سطحها CD 41 و CD 42 و CD 61 positiveالجهة
+
+224
+00:20:16,980 --> 00:20:21,200
+الادائية الـ Myeloplast بتتميز بوجود CD 13 تلاتة و
+
+225
+00:20:21,200 --> 00:20:26,080
+تلاتين positive TDT negative و M6 بيكون على سطح
+
+226
+00:20:26,080 --> 00:20:31,220
+الجلاجفورين A positive و M7 بيكون على سطح CD 41 42
+
+227
+00:20:31,220 --> 00:20:36,200
+61 positive بينما
+
+228
+00:20:36,200 --> 00:20:41,300
+الـ lymphoplastic leukemia التفصيل فيها كان أكثر
+
+229
+00:20:41,300 --> 00:20:47,500
+شنية الـ immunophenotaping يستخدم أكثر للمفو بلاست
+
+230
+00:20:47,500 --> 00:20:52,140
+من الميلو بلاست شو عملوا قسموها إليها تعرف احنا
+
+231
+00:20:52,140 --> 00:20:59,240
+اللمفو بلاست اما بي واما تي و جالوا الـ بي بتمر في
+
+232
+00:20:59,240 --> 00:21:04,580
+مراحل مختلفة من ضمنها الـ precursor بي ثم الـ بي
+
+233
+00:21:04,580 --> 00:21:09,240
+فجالوا الـ precursor بي على سطحها بيكون اللي هو CD19
+
+234
+00:21:09,240 --> 00:21:14,890
+positive وبيكون في حالة بيسموها cytoplasmic CD22
+
+235
+00:21:14,890 --> 00:21:19,430
+Positive يعني موجود في الـ Cytoplasm و بيكون الـ TDT
+
+236
+00:21:19,430 --> 00:21:23,290
+Positive زي ما أنتم شايفين TDT Positive لأن هو
+
+237
+00:21:23,290 --> 00:21:28,970
+هذه الـ Lymphoplasty و غالبا دي الـ precursor بتشمل
+
+238
+00:21:28,970 --> 00:21:35,630
+ثلاثة أنواع بالإضافة للـ CD اللي ثاني ذكرناهم جانوا
+
+239
+00:21:35,630 --> 00:21:38,350
+في الـ Common Type Common Acute Lymphoplastic
+
+240
+00:21:38,350 --> 00:21:45,620
+Leukemia بيكون الـ CD10 Positive و في المرضى بأكيوت
+
+241
+00:21:45,620 --> 00:21:49,400
+لنفو بلاستيك لوكيميا بيكون CD10 نيجاتيف اسمها
+
+242
+00:21:49,400 --> 00:21:54,140
+نالوت يعني ما فيش و في الـ B بي أكيوت لنفو بلاستيك
+
+243
+00:21:54,140 --> 00:21:58,180
+لوكيميا بيكون اما CD10 positive و مرات بيكون فيه
+
+244
+00:21:58,180 --> 00:22:04,460
+CD10 نيجاتيف الجهد ما يخص اللي هو الـ precursor P
+
+245
+00:22:04,460 --> 00:22:08,500
+إنما في الـ بي أكيوت لنفو بلاستيك يعني الـ mature
+
+246
+00:22:08,500 --> 00:22:14,200
+type of بي أكيوت لنفو بلاستيك لوكيميا بالإضافة لـ
+
+247
+00:22:14,200 --> 00:22:19,900
+CD19 positive و Cytoplasm 22 positive بتتميز
+
+248
+00:22:19,900 --> 00:22:22,920
+بشغلتين أن هدى صارت mature أن في على سطح
+
+249
+00:22:22,920 --> 00:22:26,480
+أمينوجلوبيولين وبالتالي الـ surface أمينوجلوبيولين is
+
+250
+00:22:26,480 --> 00:22:32,120
+positive وبيكون الـ TDT is negative ليش الـ TDT is
+
+251
+00:22:32,120 --> 00:22:36,660
+negative؟ لأن هذا عبارة عن انزيم مشترك إذا كنت
+
+252
+00:22:36,660 --> 00:22:41,160
+نيوكليار كنترولر في الـ Immature Form و احنا بنحكي
+
+253
+00:22:41,160 --> 00:22:47,640
+عن علشان الـ Immature Form النوع الثاني اللي هو
+
+254
+00:22:47,640 --> 00:22:50,440
+الـ T-Acute Lymphopnostic Leukemia جالوا بيتميز
+
+255
+00:22:50,440 --> 00:22:57,300
+بوجود CD هاتف بس أرقام هاتفية زي CD007 positive و
+
+256
+00:22:57,300 --> 00:23:02,940
+يكون فيه CD-Cytoplasmic CD3 positive وأيضا بيكون
+
+257
+00:23:02,940 --> 00:23:11,120
+على سطح الـ TDT Positive لما بدوا يحكوا على ..
+
+258
+00:23:11,120 --> 00:23:15,860
+بشكل عام على التصنيفات الـ Lymphoplastic Leukemia
+
+259
+00:23:15,860 --> 00:23:20,500
+whether it's L1 or L2 or L3 جالوا أن البيئة أكيد
+
+260
+00:23:20,500 --> 00:23:26,800
+Lymphoplastic Leukemia هي عبارة عن L3 بينما CD10
+
+261
+00:23:26,800 --> 00:23:31,730
+Positive اللي هي الـ common و الـ null تن نيجاتيف تن
+
+262
+00:23:31,730 --> 00:23:32,590
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+263
+00:23:32,590 --> 00:23:37,290
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+264
+00:23:37,290 --> 00:23:41,990
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+265
+00:23:41,990 --> 00:23:45,390
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+266
+00:23:45,390 --> 00:23:46,970
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+267
+00:23:46,970 --> 00:23:49,030
+نيجاتيف تن نيجاتيف تن نيجاتيف تن نيجاتيف تن
+
+268
+00:23:49,030 --> 00:23:58,290
+نيجاتيف تن نيجاتيف تن نيجاتيف
+
+269
+00:23:58,630 --> 00:24:02,150
+طب مين اللي بنميزها؟ يالله الـ Immunophenotype مين
+
+270
+00:24:02,150 --> 00:24:06,650
+اللي بتعرف عليها؟ By immunophenotype يعني By this
+
+271
+00:24:06,650 --> 00:24:15,150
+classification technique و كنا بنعرف للتسجيل أن
+
+272
+00:24:15,150 --> 00:24:20,490
+الـ بالإنفسايت بتمر في مراحل مختلفة للندوش هاي الـ
+
+273
+00:24:20,490 --> 00:24:27,360
+progenitor cell أول هذه المراحل CD موجود ويكون على
+
+274
+00:24:27,360 --> 00:24:32,620
+سطحها أربعة و تلاتين positive و CD تسعتاش positive
+
+275
+00:24:32,620 --> 00:24:38,540
+CD أربعة و تلاتين مقابرة على stencil marker فاحنا
+
+276
+00:24:38,540 --> 00:24:46,380
+بنحكي جاعدين على very immature stages ايوه و بعد
+
+277
+00:24:46,380 --> 00:24:50,480
+هيك صار فيه cytoplasmic CD تنين و عشرين positive
+
+278
+00:24:54,530 --> 00:25:01,450
+و تسعة عشر positive و عشرة positive آيات كمان
+
+279
+00:25:01,450 --> 00:25:07,530
+المرحلة اللي بعدها الـ pre B اللي هو TTT positive
+
+280
+00:25:07,530 --> 00:25:13,170
+ثم تسعة عشر و عشر أو عشرين و surface بدل 
+
+281
+00:25:13,170 --> 00:25:17,510
+cytoplasmic surface CD 22 positive
+
+282
+00:25:20,110 --> 00:25:27,450
+Cytoplasmic Immunoglobulin-MU أول
+
+283
+00:25:27,450 --> 00:25:31,170
+مبتدأ تتكوين في الـCytoplasm بعدين تطلع على السطح
+
+284
+00:25:31,170 --> 00:25:37,270
+الخلق ماشي لغاية الآن نحكي على الـMature Form TDT
+
+285
+00:25:37,270 --> 00:25:42,160
+المرحلة التالية هي mature form  بأكد لنفو
+
+286
+00:25:42,160 --> 00:25:48,040
+بلاستيك لوكيميا براحة TDT مش موجود لأنه يوصل موجود
+
+287
+00:25:48,040 --> 00:25:54,420
+في ال mature و 19 و 20 و surface TDT 28 positive و
+
+288
+00:25:54,420 --> 00:25:55,700
+يكون على السطح surface
+
+289
+00:25:59,940 --> 00:26:06,540
+هذه ممكن تشكل فيه أو تنصاب بـ different types of
+
+290
+00:26:06,540 --> 00:26:08,720
+leukemia منها ال chronic lymphocytic leukemia و ال
+
+291
+00:26:08,720 --> 00:26:11,300
+chronic lymphocytic leukemia و ال pro lymphocytic
+
+292
+00:26:11,300 --> 00:26:16,580
+leukemia هذي بيكون على السطح ليرس اللوكيميا هذي
+
+293
+00:26:16,580 --> 00:26:18,720
+بيكون هدولة على السطح و old and strong
+
+294
+00:26:18,720 --> 00:26:22,960
+microglobulinemia هناخدها برضه و ال multiple
+
+295
+00:26:22,960 --> 00:26:26,500
+myeloma أو الasbestosis برضه تتميز بها دي ال
+
+296
+00:26:26,500 --> 00:26:30,280
+markers different markers are seen according to
+
+297
+00:26:30,280 --> 00:26:34,680
+different stage of maturation وبالتالي من الماركر
+
+298
+00:26:34,680 --> 00:26:38,020
+اللي على سطح هذه الخلية نقدر نتعرف which stage is
+
+299
+00:26:38,020 --> 00:26:43,260
+involved or is seen نفس الحكاية في ال T بس دائماً
+
+300
+00:26:43,260 --> 00:26:45,900
+انتوا شايفين ال T ماشي
+
+301
+00:26:47,830 --> 00:26:52,150
+TDT في مراحل الـ Procytes و Thymocytes موجود و
+
+302
+00:26:52,150 --> 00:27:00,630
+present و Cytoplasmic CD3 مع CD7 ثم في ال Cortical
+
+303
+00:27:00,630 --> 00:27:04,810
+لأن هذه مرحلة من مراحل ال Thymocytes راحت على
+
+304
+00:27:04,810 --> 00:27:08,970
+Thymus و بيكون ال TDT still there و كل هدول
+
+305
+00:27:08,970 --> 00:27:14,640
+بيكونوا موجودين و كما تشوفون كلهم أرقام قليلة كنا
+
+306
+00:27:14,640 --> 00:27:18,080
+بتحكي هناك في ال B على تسعتاش و اتنين و عشرين و
+
+307
+00:27:18,080 --> 00:27:23,640
+عشرين مظبوط هنا بتحكي على أقصى واحد تمانية أكبر
+
+308
+00:27:23,640 --> 00:27:28,500
+رقم تمانية بعدين ال T اللي هو ال mature form اللي
+
+309
+00:27:28,500 --> 00:27:33,480
+يقول إنّها إما بتكون CD4 أو CD8 و أيضاً على سطح كل
+
+310
+00:27:33,480 --> 00:27:33,880
+هدول
+
+311
+00:27:37,630 --> 00:27:41,070
+أنا كمان قلنا في أداة رابعة وهي الـ cytogenetic
+
+312
+00:27:41,070 --> 00:27:45,710
+بمعنى أنه فيه سجلت حالات chromosomal abnormality
+
+313
+00:27:45,710 --> 00:27:50,930
+في معظم أنواع اللوكيميا وإنه لما وجود ال
+
+314
+00:27:50,930 --> 00:27:52,530
+cytogenetic abnormality
+
+315
+00:27:55,080 --> 00:27:59,140
+هو استخدام للتقنية والتقنية الهيموترولوجية
+
+316
+00:27:59,140 --> 00:28:11,040
+المالكتانسية الهيموترولوجية
+
+317
+00:28:11,040 --> 00:28:12,020
+المالكتانسية الهيموترولوجية الهيموترولوجية
+
+318
+00:28:12,020 --> 00:28:12,640
+الهيموترولوجية الهيموترولوجية الهيموترولوجية
+
+319
+00:28:12,640 --> 00:28:12,860
+الهيموترولوجية الهيموترولوجية الهيموترولوجية
+
+320
+00:28:12,860 --> 00:28:13,680
+الهيموترولوجية الهيموترولوجية الهيموترولوجية
+
+321
+00:28:13,680 --> 00:28:13,820
+الهيموترولوجية الهيموترولوجية الهيموترولوجية
+
+322
+00:28:13,820 --> 00:28:20,230
+الهيموترولوجية الهيموترولوجية الهبتتميز بالـ
+
+323
+00:28:20,230 --> 00:28:26,790
+specific chromosomal abnormality والنت مليان سجلت
+
+324
+00:28:26,790 --> 00:28:29,750
+حالات chromosomal abnormality في معظم أنواع
+
+325
+00:28:29,750 --> 00:28:35,830
+اللوكيميا طبعاً ممكن translocation ممكن أنيوبلايدي
+
+326
+00:28:38,070 --> 00:28:43,730
+والنوع المحدد لهذه المالكدنسية يمكن أن يكون
+
+327
+00:28:43,730 --> 00:28:51,350
+اكتشافه بحسب نوع الكرموزومة الابنورمالية اللي
+
+328
+00:28:51,350 --> 00:28:51,990
+موجودة
+
+329
+00:28:54,510 --> 00:28:59,030
+طبعاً احنا ممكن قبل لعبة نشوف يعني كيف نحدد
+
+330
+00:28:59,030 --> 00:29:02,030
+الكرموزومة لاب نورمالتي كلكم تعرفوا ال molecular
+
+331
+00:29:02,030 --> 00:29:04,890
+technique اللي بنستخدم أو ال cytogenetic technique
+
+332
+00:29:04,890 --> 00:29:09,930
+و أول هذا ال techniques اللي هو ال traditional
+
+333
+00:29:09,930 --> 00:29:16,310
+method اللي هي ال carry typing و في آخر DNA based
+
+334
+00:29:16,310 --> 00:29:20,570
+technique اللي هم تستخدم برضه
+
+335
+00:29:22,520 --> 00:29:29,740
+بنتعرف من خلالها على اللي هو ال chromosome ال
+
+336
+00:29:29,740 --> 00:29:36,060
+abnormality اللي موجودة طبعاً زي ما اتفقنا إذا وجد
+
+337
+00:29:36,060 --> 00:29:38,760
+ال chromosome ال abnormality في ال malignancy
+
+338
+00:29:38,760 --> 00:29:42,740
+بيكون ال prognosis is bad وإذا ما فيش إذا كان
+
+339
+00:29:42,740 --> 00:29:47,820
+normal كال retyping بيكون فيه good prognosis بمعنى
+
+340
+00:29:47,820 --> 00:29:55,480
+أنّه future of disease is better than the
+
+341
+00:29:55,480 --> 00:30:01,900
+chromosomal abnormality هذا مثال على translocation
+
+342
+00:30:01,900 --> 00:30:07,900
+ما بين سبعة و تمانية كرموزوم سبعة و تمانية في ال qr
+
+343
+00:30:07,900 --> 00:30:12,120
+مقبوظ صار فيه translocation و طبعاً هذا الكلام احنا
+
+344
+00:30:12,120 --> 00:30:17,520
+تخطوه في ال molecular biology بالتفصيل هنا صورة
+
+345
+00:30:17,520 --> 00:30:22,200
+لكاريو تايمبنشوف من خلالها بنصفط الكرموزومات واحد
+
+346
+00:30:22,200 --> 00:30:25,360
+ورا الثاني ماشي و زي ما انتوا عارفين أن
+
+347
+00:30:25,360 --> 00:30:30,900
+الكرموزومات الكبيرة تبدأ كبيرة و تبدأ تصغر كل ما
+
+348
+00:30:30,900 --> 00:30:39,520
+زيّ ما بنزيد في العدد صفطها و بنتفرج على شكل الكرموزوم و
+
+349
+00:30:39,520 --> 00:30:41,520
+هل في abnormality ولا ما فيش
+
+350
+00:30:43,980 --> 00:30:47,000
+طبعاً زي ما قلتلكوا ست دي اتحالات كروموزوم الأبناء
+
+351
+00:30:47,000 --> 00:30:50,940
+الماتى في معظم أنواع اللوكيميا أنا اختارتلكوا واحد
+
+352
+00:30:50,940 --> 00:30:56,580
+أو اثنين بالكثير في الغالب واحد لكل نوع من أنواع
+
+353
+00:30:56,580 --> 00:31:00,800
+اللوكيميا اللي احنا حكينا فيها ففي اللاكتلينف و ال
+
+354
+00:31:00,800 --> 00:31:04,370
+plastic في أقل واحد و أقل اثنين فيه Translocation
+
+355
+00:31:04,370 --> 00:31:08,250
+تسعة و اثنين و عشرين في ال Brady اتلت ليمفو
+
+356
+00:31:08,250 --> 00:31:13,950
+بلاستيك لوكيميا في في Translocation واحد بين واحد
+
+357
+00:31:13,950 --> 00:31:19,060
+و تسعة عشر و غالباً تكون أقل واحد وهي في البيئة
+
+358
+00:31:19,060 --> 00:31:23,200
+كيوتلينفر بلاستيكلا كيميا زي ما بتلاحظها بتكون ال
+
+359
+00:31:23,200 --> 00:31:28,420
+ثلاثة وفيها أكثر من Translocation بس معظمهم كرموزوم
+
+360
+00:31:28,420 --> 00:31:31,640
+رقم ثمانية is involved ثمانية أربعة عشرة ثمانية اثنين
+
+361
+00:31:31,640 --> 00:31:37,240
+وعشرين ثمانية اثنين ثمانية المهم ثمانية is present
+
+362
+00:31:37,240 --> 00:31:40,740
+اللي بالنسبة لل T اللي هنا ممكن تكون أقل واحد
+
+363
+00:31:40,740 --> 00:31:43,840
+وممكن تكون أقل اثنين يعني ال Translocation اللي
+
+364
+00:31:43,840 --> 00:31:49,490
+اختارتلكوا هو Translocation 1114 بالنسبة للأكيد
+
+365
+00:31:49,490 --> 00:31:56,450
+Myeloid Leukemia احنا قلنا فيها من M0 ل M7 أنا
+
+366
+00:31:56,450 --> 00:32:00,750
+اخترتلكوا هذه الأنواع M2 فيها Translocation 28 و
+
+367
+00:32:00,750 --> 00:32:07,850
+21 M3 Translocation 15 و 17 M4 Invergence 16 أو
+
+368
+00:32:07,850 --> 00:32:13,110
+Translocation بين 16 و 16 و M5 Deletion أو
+
+369
+00:32:13,110 --> 00:32:16,980
+Translocation في 11 و M6 اللي هو Translocation ما
+
+370
+00:32:16,980 --> 00:32:25,140
+بين 8 و 16 هذا الجدول اللي حفظنا بهيك
+
+371
+00:32:25,140 --> 00:32:29,360
+بنكون باستخدام هذه الأداة اللي هو الـ cytogenetic
+
+372
+00:32:29,360 --> 00:32:37,880
+تقريباً 99% من الحالات بتكون وعشان أكون دقيق تقريباً
+
+373
+00:32:37,880 --> 00:32:41,940
+97% من الحالات اللي كيميا بتكون can be classified
+
+374
+00:32:41,940 --> 00:32:47,690
+can be known can be diagnosed و بيظل في بعض الحالات
+
+375
+00:32:47,690 --> 00:32:53,130
+القليلة ليه which have both اللي هو myeloid and
+
+376
+00:32:53,130 --> 00:32:57,870
+lymphoid series أو surface على سطحها بيسموها acute
+
+377
+00:32:57,870 --> 00:33:03,470
+undifferentiated leukemia نيجي لل pathophysiology
+
+378
+00:33:03,470 --> 00:33:08,690
+of acute leukemia شو بتعمل ال acute leukemia لأن
+
+379
+00:33:08,690 --> 00:33:12,750
+ال acute leukemia بتسبب ال morbidity و ال
+
+380
+00:33:12,750 --> 00:33:19,290
+mortality من خلال ثلاثة general mechanism أول واحد
+
+381
+00:33:19,290 --> 00:33:22,390
+deficiency in normal blood cell number or function
+
+382
+00:33:22,390 --> 00:33:27,750
+normal cell احنا قلنا باسمها إحلال بواسطة خلايا
+
+383
+00:33:27,750 --> 00:33:32,650
+غير طبيعية هنشوف إيش بتعمل نمرة اثنين invasion of
+
+384
+00:33:32,650 --> 00:33:37,230
+vital organs احنا قلنا الخلية السرطانية بتخزق ال
+
+385
+00:33:37,230 --> 00:33:40,030
+body organs
+
+386
+00:33:41,790 --> 00:33:46,190
+وبالتالي بيحصل فيه impairment لل function of the
+
+387
+00:33:46,190 --> 00:33:52,790
+organ نمرة ثلاثة في metabolic disturbances أو
+
+388
+00:33:52,790 --> 00:33:56,670
+systemic disturbances كل الجسم بتخربط لأنه ال
+
+389
+00:33:56,670 --> 00:34:02,450
+metabolism صار فيه imbalances يجي نحكي في أول هذه
+
+390
+00:34:02,450 --> 00:34:06,310
+الحاجات وهو deficiency of normal blood cell number
+
+391
+00:34:06,310 --> 00:34:10,030
+and function وإنّها بتعمل bone marrow failure أشهر
+
+392
+00:34:10,030 --> 00:34:14,110
+حاجاتها تعمل .. ما فيش .. ما فيش normal cell فالمريض
+
+393
+00:34:14,110 --> 00:34:20,130
+بيقش في infection في hemorrhage و في anemia و
+
+394
+00:34:20,130 --> 00:34:27,830
+غالباً المريض يشخص بحالة أو أكثر من حالة من هذه
+
+395
+00:34:27,830 --> 00:34:33,230
+الحالات الثلاث  دمرة اثنين بتاخد الخلية السرطانية
+
+396
+00:34:33,230 --> 00:34:38,750
+tissue أو أعضاء الجسم فبيصير فيه إعادة في اللعب في
+
+397
+00:34:38,750 --> 00:34:41,810
+الـ spleen في الـ lymph nodes مرة بتروح الجمب مرة
+
+398
+00:34:41,810 --> 00:34:44,970
+بتروح الـ bone marrow و بيصير فيه أو طبعاً sorry في
+
+399
+00:34:44,970 --> 00:34:48,390
+كل الحالات في الـ bone marrow بس بيصير فيه
+
+400
+00:34:48,390 --> 00:34:53,710
+generalized bone pain و other organs that can be
+
+401
+00:34:53,710 --> 00:34:56,130
+infiltrated زي الـ central nervous system, skin
+
+402
+00:34:56,130 --> 00:35:00,050
+testes and any organs in the body لأن الدم بيسكر
+
+403
+00:35:00,050 --> 00:35:04,180
+من أنحاء الجسم وبالتالي الخلية تستطيع أن تصل إلى كل
+
+404
+00:35:04,180 --> 00:35:08,440
+أعضاء جسم الإنسان وممكن تعشش فيه أي عضو من الأعضاء
+
+405
+00:35:08,440 --> 00:35:15,700
+وبالتالي بتصيبه بإنفارشن
+
+406
+00:35:15,700 --> 00:35:19,240
+في الآخر مسير non-functioning وهذا مثال على ال gum
+
+407
+00:35:19,240 --> 00:35:24,060
+hypertrophy شايفين كيف ال involvement of gum
+
+408
+00:35:24,560 --> 00:35:29,180
+الأسنان تماماً اختفت لأنه كبرت صار فيه mass كلنا في
+
+409
+00:35:29,180 --> 00:35:34,020
+الآخر بيصير فيه mass of cell على سطح في المكان
+
+410
+00:35:34,020 --> 00:35:41,700
+اللي بتهيأ أي هنا فيه chloromass أي ليه skin
+
+411
+00:35:41,700 --> 00:35:45,500
+involvement سواء كان في الرأس في الصلاة أو في
+
+412
+00:35:45,500 --> 00:35:48,340
+other place في الجسم
+
+413
+00:35:51,880 --> 00:35:56,600
+طبعاً بيعمل فاهرة بيسموها اليكوستاسيز اليكوستاسيز
+
+414
+00:35:56,600 --> 00:36:01,380
+إيش اللي بيصير اليكوستاتيك ال tumor إن بيصير في
+
+415
+00:36:01,380 --> 00:36:08,160
+accumulation of blood in micro circulation و بتحشر
+
+416
+00:36:08,160 --> 00:36:15,500
+بتسكر ال blood vessels من كتبها وبالتالي بتمنع ال
+
+417
+00:36:15,500 --> 00:36:20,970
+perfusion الـ Perfusion اللي هو عملية تروية الأعضاء
+
+418
+00:36:20,970 --> 00:36:26,890
+بالدم متى ما سكّل الوعاء الدموي الدم بيبطل يمشي في
+
+419
+00:36:26,890 --> 00:36:30,030
+الوعاء الدموي وبالتالي بيصير فيه impairment للـ
+
+420
+00:36:30,030 --> 00:36:35,470
+Perfusion وبالتالي بيصير فيه ischemia طبعاً هذا 
+
+421
+00:36:35,470 --> 00:36:39,070
+الكلام ممكن يحصل في organs بشكل عام أو في blood 
+
+422
+00:36:39,070 --> 00:36:42,810
+vessels خارجي ففي ال lung على سبيل المثال بيعملها 
+
+423
+00:36:42,810 --> 00:36:48,910
+ابوكسيميا لأنهفلس بدا ال .. يصير فيه Pulmonary 
+
+424
+00:36:48,910 --> 00:36:54,630
+Infiltrate والـ Alveoli كلها بتبدأ تصير impaired
+
+425
+00:36:54,630 --> 00:37:01,790
+فالـ Central Nervous System بعمل stroke و
+
+426
+00:37:01,790 --> 00:37:08,470
+غالبا Leukostatic الـ tumor بنشوفه لما بيزيد عدد الـ
+
+427
+00:37:08,470 --> 00:37:12,950
+blood cell أكتر من خمسين ألف يعني بينجوسين بيصير
+
+428
+00:37:12,950 --> 00:37:19,050
+فيه hyper leukocytosis في حالات أخرى أيضًا بتصير
+
+429
+00:37:19,050 --> 00:37:22,850
+فيه sanctuary site relapse أنه للـ tumor infiltration
+
+430
+00:37:22,850 --> 00:37:27,950
+of testis and meninges وهذه مناطق ممكن تصل إلى
+
+431
+00:37:27,950 --> 00:37:33,350
+الخلية السرطانية بيسموها sanctuary اللي هي أماكن
+
+432
+00:37:33,350 --> 00:37:37,640
+حماية ليش أماكن حماية؟ لأن الـ Chemotherapy بتتخبى
+
+433
+00:37:37,640 --> 00:37:41,160
+فيها وللأسف الشخص الـ Chemotherapy لا يستطيع أن يصل
+
+434
+00:37:41,160 --> 00:37:48,560
+إليها ماشي في الـ meninges في أكتر من طبقة وفي الـ
+
+435
+00:37:48,560 --> 00:37:54,640
+testis هي خارج الجسم فبالتالي الـ drug cytotoxic is
+
+436
+00:37:54,640 --> 00:38:00,090
+poorly between these organs هذا شو بعمل؟ بعمل بعد
+
+437
+00:38:00,090 --> 00:38:03,290
+ما وقف الـ Chemotherapy بعمل relapse للمرض شو يعني؟
+
+438
+00:38:03,290 --> 00:38:06,890
+بعيد المرض مرة ثانية لأن الخلية السرطانية بتطلع من 
+
+439
+00:38:06,890 --> 00:38:11,670
+مكانها مرة ثانية وب .. ت .. على الـ blood
+
+440
+00:38:11,670 --> 00:38:19,230
+circulation وبتبدأ تغزو الجسم ب .. مرة ثانية و
+
+441
+00:38:19,230 --> 00:38:24,010
+بيصير في حاجة بسموها relapse يعني هو الـ recurrent
+
+442
+00:38:24,010 --> 00:38:25,890
+للمرض
+
+443
+00:38:27,570 --> 00:38:30,050
+الحاجة الثالثة اللي بتعملها Acute Leukemia بتعمل
+
+444
+00:38:30,050 --> 00:38:33,130
+Metabolic Disturbances فبيصير فيها Hyponatremia
+
+445
+00:38:33,130 --> 00:38:38,970
+يعني بيقلل Sodium ودي عادة common في الـ Acute Non
+
+446
+00:38:38,970 --> 00:38:43,530
+-Lymphoplastic Leukemia وسبب في ذلك أنه يعني as a
+
+447
+00:38:43,530 --> 00:38:47,770
+result or as a secondary of production of
+
+448
+00:38:47,770 --> 00:38:51,070
+Vasopressin-like substance الـ Vasopressin-like
+
+449
+00:38:51,070 --> 00:38:54,830
+substance غالبا بتكون مولودة في الـ Granules اللي
+
+450
+00:38:54,830 --> 00:39:01,150
+هي بتعمل DIC في أغلب الأحيان ثم Hypokalemia يعني
+
+451
+00:39:01,150 --> 00:39:05,990
+قلة في البوتاسيوم أيضًا بنشوفها في الـ Acute Myeloid
+
+452
+00:39:05,990 --> 00:39:10,310
+Monoblastic Leukemia والـ Acute Monoplastic
+
+453
+00:39:10,310 --> 00:39:14,770
+Leukemia وغالبا بتغرب
+
+454
+00:39:14,770 --> 00:39:18,630
+الكلى أيضًا
+
+455
+00:39:18,630 --> 00:39:24,870
+التكسير الدائم للخلايا يؤدي إلى إطلاق كبير من
+
+456
+00:39:24,870 --> 00:39:29,930
+البورين والبيريميدين في البلازما وهذا يؤدي إلى
+
+457
+00:39:29,930 --> 00:39:33,370
+زيادة في اليوريك أسيد وبالتالي يحدث فيه عند المريض
+
+458
+00:39:33,370 --> 00:39:39,990
+Hyper وهذا المريض طبعا اللي بيصير عنده
+
+459
+00:39:39,990 --> 00:39:45,250
+hyperuricemia ممكن يؤدي إلى renal damage أو renal
+
+460
+00:39:45,250 --> 00:39:50,330
+failure وبالتالي بيحتاج إلى dialysis يعني عملية
+
+461
+00:39:50,330 --> 00:39:57,610
+غسيل كلى خصوصًا إذا كان عدى مرحلة متقدمة من الـ
+
+462
+00:39:57,610 --> 00:40:02,850
+renal damage بدنا ننسى أن كمان الـ Cytotoxic drug
+
+463
+00:40:02,850 --> 00:40:07,530
+اللي بياخده هو عبارة عن نفرو toxic بمعنى toxic
+
+464
+00:40:07,530 --> 00:40:13,590
+للـ كلى يعني للكلى وبالتالي هذا بيزود الـ severity
+
+465
+00:40:13,590 --> 00:40:21,530
+of minor metabolic disturbances وبيزود اللي هو
+
+466
+00:40:21,530 --> 00:40:25,270
+secondary to massive cell lysis طبعا وبالتالي
+
+467
+00:40:25,270 --> 00:40:31,460
+بيصير فيه renal damage من هذا الكلام ممكن يعمل اللي
+
+468
+00:40:31,460 --> 00:40:35,540
+هو طبعا توكيميا وحكينا في حاجات كثيرة اللي هو
+
+469
+00:40:35,540 --> 00:40:39,360
+therapy induced ونفس الـ drug اللي هو الـ
+
+470
+00:40:39,360 --> 00:40:43,620
+Chemotherapy هو عبارة عن toxic drug في طبعا
+
+471
+00:40:43,620 --> 00:40:48,160
+constitutional symptoms مريض يعني من fever من 
+
+472
+00:40:48,160 --> 00:40:53,400
+sweats which is common لأنه في high metabolic rate
+
+473
+00:40:53,400 --> 00:41:01,500
+of .. الـ metabolism بيكون عاليًا من خلالها لو كان
+
+474
+00:41:01,500 --> 00:41:06,220
+هناك تعرق شديد ويؤدي إلى نقصان في الوزن بشكل فظيع
+
+475
+00:41:06,220 --> 00:41:09,800
+أشهر الـ laboratory feature اللي لازم نعملها نعمل
+
+476
+00:41:09,800 --> 00:41:13,740
+white blood cell بتكون عالية في الغالب لكن ممكن
+
+477
+00:41:13,740 --> 00:41:16,920
+تكون normal وممكن تكون low عشان هي بتقول في الـ
+
+478
+00:41:16,920 --> 00:41:23,870
+acute leukemia الـ white blood cell is variable نمرة
+
+479
+00:41:23,870 --> 00:41:27,350
+2 بـ Blast نشوفها في الـ Peripheral Blood نمرة 3
+
+480
+00:41:27,350 --> 00:41:30,070
+في أنيميا والأنيميا دي عبارة عن Normal Cytic
+
+481
+00:41:30,070 --> 00:41:35,170
+Normochronic وفي Thrombocytopenia وفي Neutropenia
+
+482
+00:41:35,170 --> 00:41:40,730
+وقلنا في كثير من الحالات بيصير في DIC بعد هيك بنعمل
+
+483
+00:41:40,730 --> 00:41:43,550
+bone marrow في الـ acute leukemia الـ bone marrow
+
+484
+00:41:43,550 --> 00:41:48,490
+بيكون it's necessary for diagnosis أصلا ما بيعطوا
+
+485
+00:41:48,490 --> 00:41:50,610
+Chemotherapy وعلاج إلا بعد الـ bone marrow
+
+486
+00:41:50,610 --> 00:41:56,950
+investigation وغالبا خلال الـ bone marrow بنحدد نوع الـ
+
+487
+00:41:56,950 --> 00:42:02,930
+leukemia ومهم جدا في الـ prognosis و acute leukemia
+
+488
+00:42:02,930 --> 00:42:07,130
+أيضًا بنعرفها بإنه في وجود أكتر من عشرين بالمائة
+
+489
+00:42:07,130 --> 00:42:10,990
+التعريف بيقول تلاتين في المائة من الـ Blast في الـ Bone marrow
+
+490
+00:42:10,990 --> 00:42:16,170
+is a definition of leukemia كيف نفرق بين الـ acute
+
+491
+00:42:16,170 --> 00:42:18,390
+myeloid leukemia والـ acute lymphoplastic
+
+492
+00:42:18,390 --> 00:42:22,130
+leukemia؟ يعني في الـ light microscopy بنشوف في الـ
+
+493
+00:42:22,130 --> 00:42:25,670
+acute myeloid leukemia Auerod body وفيه granules
+
+494
+00:42:25,670 --> 00:42:28,770
+بينما في الـ acute lymphoplastic leukemia لا في 
+
+495
+00:42:28,770 --> 00:42:33,540
+Auerod body ولا فيه granules أيضًا باستخدام flow
+
+496
+00:42:33,540 --> 00:42:37,620
+cytometry نستطيع أن نفرق حسب الـ CD اللي على سطحها
+
+497
+00:42:37,620 --> 00:42:42,500
+immunophenotyping أو باستخدام special stain زي الـ
+
+498
+00:42:42,500 --> 00:42:47,940
+cytochemical staining وده شكل acute myeloplastic
+
+499
+00:42:47,940 --> 00:42:52,080
+leukemia زي ما بيقولنا الخلية كبيرة وغالبًا
+
+500
+00:42:52,080 --> 00:42:58,370
+granular وفيها Auerod body فيها Nucleoli واضحة و
+
+501
+00:42:58,370 --> 00:43:04,330
+لا ننسى الـ purple to blue أو color of the cell
+
+502
+00:43:04,330 --> 00:43:07,010
+بشكل عام أي acute myeloid leukemia أو الـ Granulo
+
+503
+00:43:07,010 --> 00:43:11,290
+cytotic عملت license of the cell بيصير وبيصير في
+
+504
+00:43:11,290 --> 00:43:16,310
+release of granules في الـ circulation نلاحظ كمان
+
+505
+00:43:16,310 --> 00:43:20,230
+الـ Auerod body هذا هي الموجودة في الخلايا بشكل كثير
+
+506
+00:43:20,230 --> 00:43:25,550
+ماشي هذا عبارة عن أي أنواع من أنواع اللي هو Acute
+
+507
+00:43:25,550 --> 00:43:30,290
+Myeloid Leukemia هذا الشكل بينما في 
+
+508
+00:43:30,290 --> 00:43:32,550
+الـ Acute Lymphoblastic Leukemia الخلايا زي ما أنتم
+
+509
+00:43:32,550 --> 00:43:35,610
+شايفين غير granular في الغالب Nucleus مخدة حجم
+
+510
+00:43:35,610 --> 00:43:39,870
+كبير هي Heterogeneous هذه الـ L2 بالمناسبة لأنه في
+
+511
+00:43:39,870 --> 00:43:43,170
+خلايا كبيرة وخلايا صغيرة في Vacuolation في
+
+512
+00:43:43,170 --> 00:43:46,870
+الـ cytoplasm وStill the cytoplasm is purple in
+
+513
+00:43:46,870 --> 00:43:51,270
+color بهيك نكون غطينا طبعا الـ Acute Leukemia جوانب
+
+514
+00:43:51,270 --> 00:44:00,550
+نتمنى تكونوا استفدتم من هذه المحاضرة وشكرا لكم
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..c50d71e781beb82a6fda8f5a19ac8b60a88d86bb
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/Nh8KT__vN5w_raw.json
@@ -0,0 +1 @@
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بالاضافة لل immature cells اللي هي اللي موجودة اما تلاتة اللي يقول hypergranular زي ما انتوا شايفين", "tokens": [3495, 2259, 42381, 6987, 4724, 2304, 3615, 1863, 7578, 16472, 5296, 3794, 9307, 4032, 5296, 7435, 2288, 7649, 1829, 2407, 11622, 32767, 6055, 19913, 3224, 2288, 39182, 23032, 3555, 3615, 995, 23758, 8978, 19528, 3390, 2007, 8717, 2655, 30543, 3615, 8978, 3224, 49610, 23328, 14442, 5438, 20666, 46958, 31845, 3660, 24976, 49539, 5438, 13672, 1829, 39896, 13672, 1829, 3714, 29245, 23328, 3660, 1975, 15042, 6055, 1211, 9307, 3660, 13672, 1829, 7251, 39648, 9848, 42381, 1040, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957], "avg_logprob": -0.3019621968269348, "compression_ratio": 1.5572139303482586, "no_speech_prob": 0.0, "words": [{"start": 317.09, "end": 318.13, "word": "hypogranulated", "probability": 0.5369873046875}, {"start": 318.13, "end": 318.77, "word": " بمعنى", "probability": 0.86923828125}, {"start": 318.77, "end": 318.95, "word": " ان", 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{"start": 326.09, "end": 326.35, "word": " فيه", "probability": 0.812744140625}, {"start": 326.35, "end": 326.83, "word": " وجود", "probability": 0.97607421875}, {"start": 326.83, "end": 327.49, "word": " mature", "probability": 0.93603515625}, {"start": 327.49, "end": 327.97, "word": " cells", "probability": 0.90478515625}, {"start": 327.97, "end": 328.55, "word": " بالاضافة", "probability": 0.9224853515625}, {"start": 328.55, "end": 328.79, "word": " لل", "probability": 0.320068359375}, {"start": 328.79, "end": 329.27, "word": " immature", "probability": 0.93408203125}, {"start": 329.27, "end": 329.91, "word": " cells", "probability": 0.88916015625}, {"start": 329.91, "end": 330.31, "word": " اللي", "probability": 0.58203125}, {"start": 330.31, "end": 330.47, "word": " هي", "probability": 0.544921875}, {"start": 330.47, "end": 330.75, "word": " اللي", "probability": 0.880126953125}, {"start": 330.75, "end": 331.67, "word": " موجودة", "probability": 0.9881591796875}, {"start": 331.67, "end": 333.41, "word": " اما", "probability": 0.35357666015625}, {"start": 333.41, "end": 334.31, "word": " تلاتة", "probability": 0.736328125}, {"start": 334.31, "end": 335.71, "word": " اللي", "probability": 0.94189453125}, {"start": 335.71, "end": 335.89, "word": " يقول", "probability": 0.547119140625}, {"start": 335.89, "end": 336.97, "word": " hypergranular", "probability": 0.6121419270833334}, {"start": 336.97, "end": 337.69, "word": " زي", "probability": 0.772705078125}, {"start": 337.69, "end": 337.75, "word": " ما", "probability": 0.88525390625}, {"start": 337.75, "end": 337.97, "word": " انتوا", "probability": 0.8180338541666666}, {"start": 337.97, "end": 338.51, "word": " شايفين", "probability": 0.9849853515625}], "temperature": 1.0}, {"id": 14, "seek": 36556, "start": 338.92, "end": 365.56, "text": "في ان الـ cytoplasm is granulated ده هو دي عبارة عن bromilocytes granulated برضه granulated ماشي خلية كبيرة nucleus still have nucleus to cytoplasm ratio still high لكن زي ما انتوا شايفين ال granules واضحة جدا في الخلية", "tokens": [41185, 16472, 2423, 39184, 3185, 19337, 7743, 76, 307, 9370, 6987, 11778, 3224, 31439, 11778, 1829, 6225, 3555, 9640, 3660, 18871, 50134, 10720, 1344, 7269, 9370, 6987, 4724, 43042, 3224, 9370, 6987, 3714, 33599, 1829, 16490, 1211, 10632, 9122, 3555, 48923, 28055, 920, 362, 28055, 281, 3185, 19337, 7743, 76, 8509, 920, 1090, 44381, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 2423, 9370, 3473, 4032, 46958, 5016, 3660, 10874, 28259, 8978, 33962, 1211, 10632], "avg_logprob": -0.24739583906454918, "compression_ratio": 1.5698924731182795, "no_speech_prob": 0.0, "words": [{"start": 338.92, "end": 339.12, "word": "في", "probability": 0.1627197265625}, {"start": 339.12, "end": 339.44, "word": " ان", "probability": 0.5029296875}, {"start": 339.44, "end": 339.92, "word": " الـ", "probability": 0.4246826171875}, {"start": 339.92, "end": 340.82, "word": " cytoplasm", "probability": 0.8380126953125}, {"start": 340.82, "end": 341.2, "word": " is", "probability": 0.67236328125}, {"start": 341.2, "end": 342.44, "word": " granulated", "probability": 0.869873046875}, {"start": 342.44, "end": 342.94, "word": " ده", "probability": 0.44390869140625}, {"start": 342.94, "end": 343.18, "word": " هو", "probability": 0.72900390625}, {"start": 343.18, "end": 343.54, "word": " دي", "probability": 0.4669189453125}, {"start": 343.54, "end": 343.78, "word": " عبارة", "probability": 0.9849853515625}, {"start": 343.78, "end": 343.96, "word": " عن", "probability": 0.9921875}, {"start": 343.96, "end": 345.2, "word": " bromilocytes", "probability": 0.5836181640625}, {"start": 345.2, "end": 346.62, "word": " granulated", "probability": 0.78857421875}, {"start": 346.62, "end": 347.8, "word": " برضه", "probability": 0.9514973958333334}, {"start": 347.8, "end": 348.74, "word": " granulated", "probability": 0.91796875}, {"start": 348.74, "end": 349.64, "word": " ماشي", "probability": 0.90087890625}, {"start": 349.64, "end": 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{"start": 395.61, "end": 396.55, "word": " فيه", "probability": 0.7020263671875}, {"start": 396.55, "end": 397.51, "word": " subsequent", "probability": 0.50048828125}, {"start": 397.51, "end": 398.85, "word": " bleeding", "probability": 0.95458984375}, {"start": 398.85, "end": 400.39, "word": " و", "probability": 0.444091796875}, {"start": 400.39, "end": 401.23, "word": " يتميز", "probability": 0.8255615234375}, {"start": 401.23, "end": 401.59, "word": " بوجود", "probability": 0.9596354166666666}, {"start": 401.59, "end": 402.33, "word": " Translocation", "probability": 0.6569417317708334}, {"start": 402.33, "end": 402.73, "word": " 15", "probability": 0.33154296875}, {"start": 402.73, "end": 403.45, "word": "-17", "probability": 0.66845703125}, {"start": 403.45, "end": 405.75, "word": " تقريبا", "probability": 0.9642578125}, {"start": 405.75, "end": 406.09, "word": " زى", "probability": 0.671875}, {"start": 406.09, "end": 406.47, "word": " كل", "probability": 0.85888671875}, {"start": 406.47, "end": 406.61, "word": " ما", "probability": 0.873046875}, {"start": 406.61, "end": 407.03, "word": " هناك", "probability": 0.774658203125}, {"start": 407.03, "end": 407.33, "word": " شكل", "probability": 0.9658203125}, {"start": 407.33, "end": 407.87, "word": " الخلية", "probability": 0.9482421875}, {"start": 407.87, "end": 408.19, "word": " تكون", "probability": 0.775390625}, {"start": 408.19, "end": 408.55, "word": " high", "probability": 0.7109375}, {"start": 408.55, "end": 408.73, "word": " و", "probability": 0.9375}, {"start": 408.73, "end": 409.65, "word": " granulated", "probability": 0.6947021484375}, {"start": 409.65, "end": 412.25, "word": " M4", "probability": 0.91748046875}, {"start": 412.25, "end": 412.75, "word": " اللى", "probability": 0.732177734375}, {"start": 412.75, "end": 412.99, "word": " هو", "probability": 0.880859375}, {"start": 412.99, "end": 414.95, "word": " Myelomonoplastic", "probability": 0.7052734375}, {"start": 414.95, "end": 415.77, 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"word": " من", "probability": 0.69287109375}, {"start": 680.98, "end": 681.8, "word": " شغلها", "probability": 0.7725830078125}, {"start": 681.8, "end": 682.1, "word": " اول", "probability": 0.8359375}, {"start": 682.1, "end": 682.54, "word": " شغلها", "probability": 0.933349609375}, {"start": 682.54, "end": 683.08, "word": " جلدها", "probability": 0.665985107421875}, {"start": 683.08, "end": 684.0, "word": " اللي", "probability": 0.775634765625}, {"start": 684.0, "end": 684.38, "word": " هو", "probability": 0.97607421875}, {"start": 684.38, "end": 684.96, "word": " ال", "probability": 0.91015625}], "temperature": 1.0}, {"id": 27, "seek": 71228, "start": 685.92, "end": 712.28, "text": "بلاست مورفولوجي واتعرفنا على الـ morphological differences between اللي هو different type of acute myelogenous leukemia ومن العامل الآخر اللي بيعتمد عليه ال classification هو ال cytochemistry و ال cytochemistry من اسم cytochemistry بنستخدم فيه chemical staining for staining the myeloid the blast cell", 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"word": " the", "probability": 0.6591796875}, {"start": 710.18, "end": 711.32, "word": " myeloid", "probability": 0.587158203125}, {"start": 711.32, "end": 711.56, "word": " the", "probability": 0.13818359375}, {"start": 711.56, "end": 711.94, "word": " blast", "probability": 0.435302734375}, {"start": 711.94, "end": 712.28, "word": " cell", "probability": 0.9111328125}], "temperature": 1.0}, {"id": 28, "seek": 73458, "start": 713.74, "end": 734.58, "text": "و من خلال ال study بنقدر نفرق between different types of ash of leukemia و جالوا باستخدام هذا النوع اكتر من 70% من الحالات او هذه الأداة التشخيصية اكتر من 70% مع ال morphology من ال leukemia can be classified", "tokens": [2407, 9154, 16490, 1211, 6027, 2423, 2979, 44945, 28543, 2288, 8717, 5172, 2288, 4587, 1296, 819, 3467, 295, 12588, 295, 45970, 29958, 4032, 10874, 6027, 14407, 4724, 995, 14851, 9778, 3215, 10943, 23758, 28239, 45367, 1975, 4117, 2655, 2288, 9154, 5285, 4, 9154, 21542, 6027, 9307, 1975, 2407, 29538, 16247, 28259, 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"text": "بالاضافة لـ CD19 positive و Cytoplasm 22 positive بتتميز بشغلتين انه هدى صارت mature انه فى على سطح امينoglobulin وبالتالى ال surface امينoglobulin is positive وبيكون ال TDT is negative ليش ال TDT is negative؟", "tokens": [3555, 6027, 46958, 31845, 3660, 5296, 39184, 6743, 3405, 3353, 4032, 383, 4328, 404, 7743, 76, 5853, 3353, 39894, 39237, 1829, 11622, 4724, 8592, 17082, 1211, 2655, 9957, 16472, 3224, 8032, 3215, 7578, 20328, 9640, 2655, 14442, 16472, 3224, 6156, 7578, 15844, 8608, 9566, 5016, 1975, 2304, 9957, 45841, 12176, 259, 46599, 6027, 2655, 6027, 7578, 2423, 3753, 1975, 2304, 9957, 45841, 12176, 259, 307, 3353, 4032, 21292, 30544, 2423, 42606, 51, 307, 3671, 32239, 8592, 2423, 42606, 51, 307, 3671, 22807], "avg_logprob": -0.40286144434687604, "compression_ratio": 1.5052631578947369, "no_speech_prob": 0.0, "words": [{"start": 1333.04, "end": 1333.84, "word": "بالاضافة", "probability": 0.8345703125}, {"start": 1333.84, "end": 1334.2, "word": " لـ", "probability": 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mature", "probability": 0.484130859375}, {"start": 1341.94, "end": 1342.3, "word": " انه", "probability": 0.71923828125}, {"start": 1342.3, "end": 1342.4, "word": " فى", "probability": 0.7274169921875}, {"start": 1342.4, "end": 1342.56, "word": " على", "probability": 0.78076171875}, {"start": 1342.56, "end": 1342.92, "word": " سطح", "probability": 0.96875}, {"start": 1342.92, "end": 1343.9, "word": " امينoglobulin", "probability": 0.6215006510416666}, {"start": 1343.9, "end": 1344.58, "word": " وبالتالى", "probability": 0.7404052734375}, {"start": 1344.58, "end": 1344.72, "word": " ال", "probability": 0.58984375}, {"start": 1344.72, "end": 1345.0, "word": " surface", "probability": 0.7734375}, {"start": 1345.0, "end": 1346.18, "word": " امينoglobulin", "probability": 0.9239095052083334}, {"start": 1346.18, "end": 1346.48, "word": " is", "probability": 0.343017578125}, {"start": 1346.48, "end": 1346.98, "word": " positive", "probability": 0.90673828125}, {"start": 1346.98, "end": 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Immature Form النوع التاني اللي هو الـ T-Acute Lymphopnostic Leukemia جاله بيتميز بوجود CD هاتف بس أرقام هاتفية زي CD007 positive و يكون فيه CD-Cytoplasmic CD3 positive", "tokens": [1211, 33456, 23758, 6225, 3555, 9640, 3660, 18871, 16472, 11622, 995, 9957, 37893, 2655, 31747, 1975, 15730, 9122, 29399, 8717, 1829, 2407, 4117, 20292, 9640, 9122, 29399, 2288, 12610, 2288, 8978, 2423, 39184, 17322, 1503, 10126, 4032, 1975, 5016, 8315, 44945, 5016, 4117, 1829, 18871, 11203, 8592, 7649, 2423, 39184, 17322, 1503, 10126, 28239, 45367, 16712, 7649, 1829, 13672, 1829, 31439, 2423, 39184, 314, 12, 43705, 1169, 441, 25161, 404, 1771, 372, 299, 1456, 15420, 29958, 10874, 6027, 3224, 4724, 36081, 2304, 1829, 11622, 4724, 29245, 23328, 6743, 8032, 9307, 5172, 4724, 3794, 5551, 2288, 4587, 10943, 8032, 9307, 5172, 10632, 30767, 1829, 6743, 628, 22, 3353, 4032, 7251, 30544, 8978, 3224, 6743, 12, 34, 4328, 404, 7743, 13195, 6743, 18, 3353], "avg_logprob": -0.4560467474828891, "compression_ratio": 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{"start": 1366.74, "end": 1367.28, "word": " التاني", "probability": 0.94580078125}, {"start": 1367.28, "end": 1367.42, "word": " اللي", "probability": 0.72412109375}, {"start": 1367.42, "end": 1367.64, "word": " هو", "probability": 0.9873046875}, {"start": 1367.64, "end": 1367.82, "word": " الـ", "probability": 0.84228515625}, {"start": 1367.82, "end": 1367.92, "word": " T", "probability": 0.6650390625}, {"start": 1367.92, "end": 1368.28, "word": "-Acute", "probability": 0.5879720052083334}, {"start": 1368.28, "end": 1369.0, "word": " Lymphopnostic", "probability": 0.5831298828125}, {"start": 1369.0, "end": 1369.54, "word": " Leukemia", "probability": 0.92236328125}, {"start": 1369.54, "end": 1369.84, "word": " جاله", "probability": 0.68408203125}, {"start": 1369.84, "end": 1370.44, "word": " بيتميز", "probability": 0.8568359375}, {"start": 1370.44, "end": 1371.12, "word": " بوجود", "probability": 0.96923828125}, {"start": 1371.12, "end": 1372.18, "word": " CD", "probability": 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"probability": 0.9228515625}], "temperature": 1.0}, {"id": 60, "seek": 153771, "start": 1520.11, "end": 1537.71, "text": "Cytoplasmic Immunoglobulin-MU اول مبتدأ تتكوين في الـCytoplasm بعدين تطلع على سطح الخلق ماشي لغاية الان نحكي على الـMature Form TDT موجود", "tokens": [34, 4328, 404, 7743, 13195, 17322, 409, 45841, 12176, 259, 12, 44, 52, 1975, 12610, 3714, 3555, 2655, 3215, 10721, 6055, 2655, 4117, 2407, 9957, 8978, 2423, 39184, 34, 4328, 404, 7743, 76, 39182, 9957, 6055, 9566, 1211, 3615, 15844, 8608, 9566, 5016, 33962, 1211, 4587, 3714, 33599, 1829, 5296, 17082, 995, 10632, 2423, 7649, 8717, 5016, 4117, 1829, 15844, 2423, 39184, 44, 1503, 10126, 42606, 51, 3714, 29245, 23328], "avg_logprob": -0.46170773640484875, "compression_ratio": 1.221556886227545, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1520.1100000000001, "end": 1520.93, "word": "Cytoplasmic", "probability": 0.78076171875}, {"start": 1520.93, "end": 1521.75, "word": " Immunoglobulin", "probability": 0.86572265625}, {"start": 1521.75, "end": 1522.13, "word": "-MU", "probability": 0.44775390625}, {"start": 1522.13, "end": 1527.45, "word": " اول", "probability": 0.524169921875}, {"start": 1527.45, "end": 1529.13, "word": " مبتدأ", "probability": 0.636328125}, {"start": 1529.13, "end": 1529.53, "word": " تتكوين", "probability": 0.68759765625}, {"start": 1529.53, "end": 1529.61, "word": " في", "probability": 0.84228515625}, {"start": 1529.61, "end": 1530.23, "word": " الـCytoplasm", "probability": 0.7303292410714286}, {"start": 1530.23, "end": 1530.45, "word": " بعدين", "probability": 0.37689208984375}, {"start": 1530.45, "end": 1530.77, "word": " تطلع", "probability": 0.82061767578125}, {"start": 1530.77, "end": 1530.89, "word": " على", "probability": 0.88525390625}, {"start": 1530.89, "end": 1531.17, "word": " سطح", "probability": 0.9762369791666666}, {"start": 1531.17, "end": 1531.59, "word": " الخلق", "probability": 0.6460774739583334}, {"start": 1531.59, "end": 1533.99, "word": " ماشي", "probability": 0.6395670572916666}, {"start": 1533.99, "end": 1534.37, "word": " لغاية", "probability": 0.9525146484375}, {"start": 1534.37, "end": 1534.69, "word": " الان", "probability": 0.6640625}, {"start": 1534.69, "end": 1535.05, "word": " نحكي", "probability": 0.8717041015625}, {"start": 1535.05, "end": 1535.21, "word": " على", "probability": 0.444091796875}, {"start": 1535.21, "end": 1535.71, "word": " الـMature", "probability": 0.414764404296875}, {"start": 1535.71, "end": 1536.21, "word": " Form", "probability": 0.2078857421875}, {"start": 1536.21, "end": 1537.27, "word": " TDT", "probability": 0.5902099609375}, {"start": 1537.27, "end": 1537.71, "word": " موجود", "probability": 0.9853515625}], "temperature": 1.0}, {"id": 61, "seek": 155570, "start": 1538.42, "end": 1555.7, "text": "المرحلة التالية هي mature form باكيد لينفو بلاستيك لوكينيا براحة TDT مش موجود لانه يوصي موجود في ال mature و 19 و 20 و surface TDT 28 positive و يكون على السطحة surface", "tokens": [6027, 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1541.82, "word": " باكيد", "probability": 0.415283203125}, {"start": 1541.82, "end": 1542.16, "word": " لينفو", "probability": 0.56024169921875}, {"start": 1542.16, "end": 1542.6, "word": " بلاستيك", "probability": 0.86630859375}, {"start": 1542.6, "end": 1543.12, "word": " لوكينيا", "probability": 0.734130859375}, {"start": 1543.12, "end": 1544.62, "word": " براحة", "probability": 0.79217529296875}, {"start": 1544.62, "end": 1545.24, "word": " TDT", "probability": 0.6298828125}, {"start": 1545.24, "end": 1545.58, "word": " مش", "probability": 0.367919921875}, {"start": 1545.58, "end": 1546.88, "word": " موجود", "probability": 0.9861653645833334}, {"start": 1546.88, "end": 1547.38, "word": " لانه", "probability": 0.4400227864583333}, {"start": 1547.38, "end": 1547.72, "word": " يوصي", "probability": 0.47509765625}, {"start": 1547.72, "end": 1548.04, "word": " موجود", "probability": 0.9376627604166666}, {"start": 1548.04, "end": 1548.14, "word": " في", "probability": 0.697265625}, {"start": 1548.14, "end": 1548.24, "word": " ال", "probability": 0.5205078125}, {"start": 1548.24, "end": 1548.56, "word": " mature", "probability": 0.53466796875}, {"start": 1548.56, "end": 1549.54, "word": " و", "probability": 0.490966796875}, {"start": 1549.54, "end": 1550.0, "word": " 19", "probability": 0.28466796875}, {"start": 1550.0, "end": 1550.4, "word": " و", "probability": 0.82568359375}, {"start": 1550.4, "end": 1550.92, "word": " 20", "probability": 0.6962890625}, {"start": 1550.92, "end": 1551.38, "word": " و", "probability": 0.84423828125}, {"start": 1551.38, "end": 1551.88, "word": " surface", "probability": 0.56884765625}, {"start": 1551.88, "end": 1552.6, "word": " TDT", "probability": 0.7076416015625}, {"start": 1552.6, "end": 1553.18, "word": " 28", "probability": 0.5244140625}, {"start": 1553.18, "end": 1553.86, "word": " positive", "probability": 0.82421875}, {"start": 1553.86, "end": 1554.42, "word": " و", "probability": 0.72216796875}, {"start": 1554.42, "end": 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" leukemia", "probability": 0.9462890625}, {"start": 1568.54, "end": 1568.58, "word": " و", "probability": 0.25244140625}, {"start": 1568.58, "end": 1568.72, "word": " ال", "probability": 0.7666015625}, {"start": 1568.72, "end": 1569.22, "word": " chronic", "probability": 0.358154296875}, {"start": 1569.22, "end": 1570.0, "word": " lymphocytic", "probability": 0.8849283854166666}, {"start": 1570.0, "end": 1570.52, "word": " leukemia", "probability": 0.945068359375}, {"start": 1570.52, "end": 1570.66, "word": " و", "probability": 0.1920166015625}, {"start": 1570.66, "end": 1570.66, "word": " ال", "probability": 0.75146484375}, {"start": 1570.66, "end": 1570.76, "word": " pro", "probability": 0.329345703125}, {"start": 1570.76, "end": 1571.3, "word": " lymphocytic", "probability": 0.87451171875}, {"start": 1571.3, "end": 1571.92, "word": " leukemia", "probability": 0.966064453125}, {"start": 1571.92, "end": 1572.96, "word": " هذي", "probability": 0.37652587890625}, {"start": 1572.96, 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mature", "probability": 0.9697265625}, {"start": 1647.84, "end": 1648.34, "word": " form", "probability": 0.916015625}, {"start": 1648.34, "end": 1648.5, "word": " اللي", "probability": 0.7109375}, {"start": 1648.5, "end": 1648.66, "word": " يقول", "probability": 0.731689453125}, {"start": 1648.66, "end": 1648.86, "word": " انها", "probability": 0.711669921875}, {"start": 1648.86, "end": 1648.98, "word": " اما", "probability": 0.54583740234375}, {"start": 1648.98, "end": 1649.36, "word": " بتكون", "probability": 0.78564453125}, {"start": 1649.36, "end": 1649.92, "word": " CD4", "probability": 0.783935546875}, {"start": 1649.92, "end": 1650.14, "word": " او", "probability": 0.746826171875}, {"start": 1650.14, "end": 1651.18, "word": " CD8", "probability": 0.909912109375}, {"start": 1651.18, "end": 1652.0, "word": " و", "probability": 0.591796875}, {"start": 1652.0, "end": 1652.6, "word": " أيضا", "probability": 0.8347981770833334}, {"start": 1652.6, "end": 1652.78, "word": " على", 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نوع", "probability": 0.7279052734375}, {"start": 1856.14, "end": 1856.3, "word": " من", "probability": 0.96728515625}, {"start": 1856.3, "end": 1856.58, "word": " أنواع", "probability": 0.8810221354166666}, {"start": 1856.58, "end": 1857.06, "word": " اللوكيميا", "probability": 0.98955078125}, {"start": 1857.06, "end": 1857.24, "word": " اللي", "probability": 0.7281494140625}, {"start": 1857.24, "end": 1857.58, "word": " احنا", "probability": 0.90283203125}, {"start": 1857.58, "end": 1858.64, "word": " حكينا", "probability": 0.9188232421875}, {"start": 1858.64, "end": 1859.08, "word": " فيها", "probability": 0.982421875}, {"start": 1859.08, "end": 1860.08, "word": " ففي", "probability": 0.79443359375}, {"start": 1860.08, "end": 1860.72, "word": " اللاكتلينف", "probability": 0.5880998883928571}, {"start": 1860.72, "end": 1860.72, "word": " و", "probability": 0.499755859375}, {"start": 1860.72, "end": 1860.8, "word": " ال", "probability": 0.3935546875}, {"start": 1860.8, "end": 1861.1, "word": " plastic", "probability": 0.395263671875}], "temperature": 1.0}, {"id": 75, "seek": 187733, "start": 1862.17, "end": 1877.33, "text": "في أقل واحد و أقل اتنين فيه Translocation تسعة و أتنين و عشرين في ال Brady اتلت ليمفو بلاستيك لوكيميا في في Translocation واحد بين واحد و تسعة عشر و غالبا تكون أقل واحد", "tokens": [41185, 5551, 4587, 1211, 36764, 24401, 4032, 5551, 4587, 1211, 1975, 2655, 1863, 9957, 8978, 3224, 6531, 5842, 399, 6055, 3794, 27884, 4032, 5551, 2655, 1863, 9957, 4032, 6225, 46309, 9957, 8978, 2423, 31773, 1975, 2655, 1211, 2655, 5296, 32640, 5172, 2407, 4724, 15040, 14851, 1829, 4117, 45164, 4117, 32640, 25528, 8978, 8978, 6531, 5842, 399, 36764, 24401, 49374, 36764, 24401, 4032, 6055, 3794, 27884, 6225, 46309, 4032, 32771, 6027, 3555, 995, 6055, 30544, 5551, 4587, 1211, 36764, 24401], "avg_logprob": -0.3191406227648258, "compression_ratio": 1.7, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1862.17, "end": 1862.43, "word": "في", "probability": 0.60107421875}, {"start": 1862.43, "end": 1862.59, "word": " أقل", "probability": 0.7242431640625}, {"start": 1862.59, "end": 1862.89, "word": " واحد", "probability": 0.9443359375}, {"start": 1862.89, "end": 1862.97, "word": " و", "probability": 0.78173828125}, {"start": 1862.97, "end": 1863.11, "word": " أقل", "probability": 0.83447265625}, {"start": 1863.11, "end": 1863.49, "word": " اتنين", "probability": 0.9290771484375}, {"start": 1863.49, "end": 1863.73, "word": " فيه", "probability": 0.5306396484375}, {"start": 1863.73, "end": 1864.37, "word": " Translocation", "probability": 0.742919921875}, {"start": 1864.37, "end": 1864.71, "word": " تسعة", "probability": 0.8502604166666666}, {"start": 1864.71, "end": 1864.87, "word": " و", "probability": 0.57666015625}, {"start": 1864.87, "end": 1864.97, "word": " أتنين", "probability": 0.80682373046875}, {"start": 1864.97, "end": 1865.07, "word": " و", "probability": 0.8671875}, {"start": 1865.07, "end": 1865.47, "word": " عشرين", "probability": 0.8738606770833334}, {"start": 1865.47, "end": 1866.67, "word": " في", "probability": 0.70849609375}, {"start": 1866.67, "end": 1866.77, "word": " ال", "probability": 0.94091796875}, {"start": 1866.77, "end": 1867.17, "word": " Brady", "probability": 0.146484375}, {"start": 1867.17, "end": 1867.97, "word": " اتلت", "probability": 0.588409423828125}, {"start": 1867.97, "end": 1868.25, "word": " ليمفو", "probability": 0.460845947265625}, {"start": 1868.25, "end": 1868.65, "word": " بلاستيك", "probability": 0.88701171875}, {"start": 1868.65, "end": 1869.31, "word": " لوكيميا", "probability": 0.80810546875}, {"start": 1869.31, "end": 1870.11, "word": " في", "probability": 0.9130859375}, {"start": 1870.11, "end": 1871.01, "word": " في", "probability": 0.338134765625}, {"start": 1871.01, "end": 1871.91, "word": " Translocation", "probability": 0.8984375}, {"start": 1871.91, "end": 1873.07, "word": " واحد", "probability": 0.96875}, {"start": 1873.07, "end": 1873.63, "word": " بين", "probability": 0.79248046875}, {"start": 1873.63, "end": 1873.95, "word": " واحد", "probability": 0.98828125}, {"start": 1873.95, "end": 1874.09, "word": " و", "probability": 0.76416015625}, {"start": 1874.09, "end": 1874.35, "word": " تسعة", "probability": 0.716064453125}, {"start": 1874.35, "end": 1874.77, "word": " عشر", "probability": 0.841796875}, {"start": 1874.77, "end": 1875.77, "word": " و", "probability": 0.82373046875}, {"start": 1875.77, "end": 1876.27, "word": " غالبا", "probability": 0.855224609375}, {"start": 1876.27, "end": 1876.57, "word": " تكون", "probability": 0.71240234375}, {"start": 1876.57, "end": 1876.79, "word": " أقل", "probability": 0.91748046875}, {"start": 1876.79, "end": 1877.33, "word": " واحد", "probability": 0.9873046875}], "temperature": 1.0}, {"id": 76, "seek": 190620, "start": 1877.68, "end": 1906.2, "text": "وهي في البيئة كيوتلينفر بلاستيكلا كيميا زي ما بتلاحظها بتكون ال تلاتة وفيها اكتر من Translocation بس معظمهم كرمزوم رقم تمانية is involved تمانية اربعتاش تمانية اتنين وعشرين تمانية اتنين تمانية المهم تمانية is present اللي بالنسبة لل T اللي هنا ممكن تكون اقل واحد وممكن تكون اقل اتنين يعني ال Translocation اللي اختارتلكوا هو Translocation 1114", "tokens": [2407, 3224, 1829, 8978, 2423, 21292, 19986, 3660, 9122, 1829, 2407, 2655, 1211, 9957, 5172, 2288, 4724, 15040, 14851, 1829, 4117, 15040, 9122, 32640, 25528, 30767, 1829, 19446, 39894, 15040, 5016, 19913, 11296, 39894, 30544, 2423, 6055, 1211, 9307, 3660, 4032, 41185, 11296, 1975, 4117, 2655, 2288, 9154, 6531, 5842, 399, 4724, 3794, 20449, 19913, 2304, 16095, 9122, 2288, 2304, 11622, 20498, 12602, 4587, 2304, 46811, 7649, 10632, 307, 3288, 46811, 7649, 10632, 1975, 25513, 34268, 33599, 46811, 7649, 10632, 1975, 2655, 1863, 9957, 4032, 3615, 46309, 9957, 46811, 7649, 10632, 1975, 2655, 1863, 9957, 46811, 7649, 10632, 9673, 16095, 46811, 7649, 10632, 307, 1974, 13672, 1829, 20666, 1863, 35457, 3660, 24976, 314, 13672, 1829, 34105, 3714, 43020, 6055, 30544, 1975, 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" ما", "probability": 0.7861328125}, {"start": 1881.38, "end": 1882.06, "word": " بتلاحظها", "probability": 0.573046875}, {"start": 1882.06, "end": 1883.0, "word": " بتكون", "probability": 0.5908203125}, {"start": 1883.0, "end": 1883.2, "word": " ال", "probability": 0.5654296875}, {"start": 1883.2, "end": 1883.88, "word": " تلاتة", "probability": 0.79827880859375}, {"start": 1883.88, "end": 1884.64, "word": " وفيها", "probability": 0.8779296875}, {"start": 1884.64, "end": 1884.9, "word": " اكتر", "probability": 0.8697509765625}, {"start": 1884.9, "end": 1885.06, "word": " من", "probability": 0.98291015625}, {"start": 1885.06, "end": 1885.72, "word": " Translocation", "probability": 0.7014973958333334}, {"start": 1885.72, "end": 1885.96, "word": " بس", "probability": 0.875244140625}, {"start": 1885.96, "end": 1886.94, "word": " معظمهم", "probability": 0.9586181640625}, {"start": 1886.94, "end": 1888.42, "word": " كرمزوم", "probability": 0.658154296875}, {"start": 1888.42, "end": 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"probability": 0.98779296875}, {"start": 1900.28, "end": 1900.46, "word": " اقل", "probability": 0.682373046875}, {"start": 1900.46, "end": 1900.74, "word": " واحد", "probability": 0.98046875}, {"start": 1900.74, "end": 1901.08, "word": " وممكن", "probability": 0.7921549479166666}, {"start": 1901.08, "end": 1901.38, "word": " تكون", "probability": 0.990478515625}, {"start": 1901.38, "end": 1901.56, "word": " اقل", "probability": 0.9856770833333334}, {"start": 1901.56, "end": 1901.98, "word": " اتنين", "probability": 0.9837646484375}, {"start": 1901.98, "end": 1902.86, "word": " يعني", "probability": 0.938232421875}, {"start": 1902.86, "end": 1903.02, "word": " ال", "probability": 0.72705078125}, {"start": 1903.02, "end": 1903.72, "word": " Translocation", "probability": 0.9156901041666666}, {"start": 1903.72, "end": 1903.84, "word": " اللي", "probability": 0.94384765625}, {"start": 1903.84, "end": 1904.44, "word": " اختارتلكوا", "probability": 0.7933349609375}, {"start": 1904.44, "end": 1904.68, "word": " هو", "probability": 0.20654296875}, {"start": 1904.68, "end": 1905.46, "word": " Translocation", "probability": 0.8717447916666666}, {"start": 1905.46, "end": 1906.2, "word": " 1114", "probability": 0.3553466796875}], "temperature": 1.0}, {"id": 77, "seek": 193507, "start": 1907.75, "end": 1935.07, "text": "بالنسبة للأكيد Myeloid Leukemia احنا قلنا فيها من M0 ل M7 انا اخترتلكوا هذه الأنواع M2 فيها Translocation 28 و 21 M3 Translocation 15 و 17 M4 Invergence 16 او Translocation بين 16 و 16 و M5 Deletion او Translocation في 11 و M6", "tokens": [3555, 6027, 1863, 35457, 3660, 24976, 10721, 4117, 25708, 1222, 10590, 327, 1456, 15420, 29958, 1975, 5016, 8315, 12174, 1211, 8315, 8978, 11296, 9154, 376, 15, 5296, 376, 22, 1975, 8315, 1975, 46456, 43500, 23275, 14407, 29538, 16247, 1863, 14407, 3615, 376, 17, 8978, 11296, 6531, 5842, 399, 7562, 4032, 5080, 376, 18, 6531, 5842, 399, 2119, 4032, 3282, 376, 19, 682, 331, 15260, 3165, 1975, 2407, 6531, 5842, 399, 49374, 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" بشكل", "probability": 0.95654296875}, {"start": 2584.79, "end": 2585.11, "word": " عام", "probability": 0.98974609375}, {"start": 2585.11, "end": 2585.37, "word": " اي", "probability": 0.723876953125}, {"start": 2585.37, "end": 2585.71, "word": " acute", "probability": 0.84130859375}, {"start": 2585.71, "end": 2586.11, "word": " myeloid", "probability": 0.748779296875}, {"start": 2586.11, "end": 2586.51, "word": " leukemia", "probability": 0.956787109375}, {"start": 2586.51, "end": 2586.61, "word": " او", "probability": 0.57769775390625}, {"start": 2586.61, "end": 2587.01, "word": " الجرانيو", "probability": 0.5995361328125}, {"start": 2587.01, "end": 2587.49, "word": " الاثيتيك", "probability": 0.6014811197916666}, {"start": 2587.49, "end": 2587.97, "word": " عملت", "probability": 0.9052734375}, {"start": 2587.97, "end": 2588.91, "word": " license", "probability": 0.68115234375}, {"start": 2588.91, "end": 2589.15, "word": " of", "probability": 0.91650390625}, {"start": 2589.15, 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2596.03, "word": " نلاحظ", "probability": 0.8878173828125}, {"start": 2596.03, "end": 2596.31, "word": " كمان", "probability": 0.9181315104166666}, {"start": 2596.31, "end": 2596.59, "word": " الاول", "probability": 0.3939208984375}, {"start": 2596.59, "end": 2596.75, "word": " ال", "probability": 0.302978515625}, {"start": 2596.75, "end": 2597.03, "word": " body", "probability": 0.806640625}, {"start": 2597.03, "end": 2597.25, "word": " هذا", "probability": 0.30126953125}, {"start": 2597.25, "end": 2597.45, "word": " هي", "probability": 0.51806640625}, {"start": 2597.45, "end": 2598.05, "word": " الموجودة", "probability": 0.8914794921875}, {"start": 2598.05, "end": 2598.31, "word": " في", "probability": 0.96142578125}, {"start": 2598.31, "end": 2599.05, "word": " الخلايا", "probability": 0.93994140625}, {"start": 2599.05, "end": 2599.53, "word": " بشكل", "probability": 0.9908854166666666}, {"start": 2599.53, "end": 2600.23, "word": " كثير", "probability": 0.9715169270833334}, {"start": 2600.23, "end": 2601.37, "word": " ماشي", "probability": 0.8515625}, {"start": 2601.37, "end": 2601.73, "word": " هذا", "probability": 0.80029296875}, {"start": 2601.73, "end": 2601.99, "word": " عبارة", "probability": 0.93212890625}, {"start": 2601.99, "end": 2602.25, "word": " عن", "probability": 0.99365234375}, {"start": 2602.25, "end": 2602.49, "word": " اي", "probability": 0.75439453125}, {"start": 2602.49, "end": 2603.37, "word": " انواع", "probability": 0.8060709635416666}, {"start": 2603.37, "end": 2603.59, "word": " من", "probability": 0.98291015625}, {"start": 2603.59, "end": 2604.07, "word": " انواع", "probability": 0.9508463541666666}, {"start": 2604.07, "end": 2604.27, "word": " اللي", "probability": 0.927978515625}, {"start": 2604.27, "end": 2604.61, "word": " هو", "probability": 0.98876953125}], "temperature": 1.0}, {"id": 104, "seek": 262719, "start": 2605.01, "end": 2627.19, "text": "أكيوت برو مايروسات الكليكيميا هذا الشكل بينما في الأكيوتليفو بلاستيكليكيميا الخلايا زي ما انتوا شايفين ايه granular في الغالب نوكلياس مخدة حجم كبير هي هيتراجنس هذه الـ L2 بالمناسبة لأنه في خلايا كبيرة وخلايا صغيرة في evacuation في الcytoplasm و still the cytoplasm is purple in color", "tokens": [10721, 4117, 1829, 35473, 4724, 32887, 19446, 13546, 41779, 9307, 33251, 20292, 4117, 32640, 25528, 23758, 25124, 28820, 49374, 15042, 8978, 16247, 4117, 1829, 35473, 20292, 5172, 2407, 4724, 15040, 14851, 1829, 4117, 20292, 4117, 32640, 25528, 33962, 15040, 25528, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 1975, 1829, 3224, 39962, 8978, 6024, 118, 6027, 3555, 8717, 2407, 4117, 20292, 32277, 3714, 9778, 41891, 11331, 7435, 2304, 9122, 3555, 13546, 39896, 8032, 36081, 2288, 26108, 1863, 3794, 29538, 2423, 39184, 441, 17, 20666, 2304, 8315, 35457, 3660, 5296, 33456, 3224, 8978, 16490, 15040, 25528, 9122, 3555, 48923, 4032, 9778, 15040, 25528, 20328, 17082, 48923, 8978, 42740, 8978, 2423, 1344, 19337, 7743, 76, 4032, 920, 264, 3185, 19337, 7743, 76, 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0.8755425347222222}, {"start": 2611.69, "end": 2612.11, "word": " الخلايا", "probability": 0.86767578125}, {"start": 2612.11, "end": 2612.29, "word": " زي", "probability": 0.43243408203125}, {"start": 2612.29, "end": 2612.39, "word": " ما", "probability": 0.8896484375}, {"start": 2612.39, "end": 2612.55, "word": " انتوا", "probability": 0.7257486979166666}, {"start": 2612.55, "end": 2612.87, "word": " شايفين", "probability": 0.95263671875}, {"start": 2612.87, "end": 2613.09, "word": " ايه", "probability": 0.7760416666666666}, {"start": 2613.09, "end": 2613.47, "word": " granular", "probability": 0.50634765625}, {"start": 2613.47, "end": 2613.83, "word": " في", "probability": 0.65625}, {"start": 2613.83, "end": 2614.33, "word": " الغالب", "probability": 0.7301025390625}, {"start": 2614.33, "end": 2615.05, "word": " نوكلياس", "probability": 0.68447265625}, {"start": 2615.05, "end": 2615.35, "word": " مخدة", "probability": 0.63037109375}, {"start": 2615.35, "end": 2615.61, "word": " حجم", "probability": 0.90283203125}, {"start": 2615.61, "end": 2616.07, "word": " كبير", "probability": 0.9933268229166666}, {"start": 2616.07, "end": 2616.53, "word": " هي", "probability": 0.69287109375}, {"start": 2616.53, "end": 2617.33, "word": " هيتراجنس", "probability": 0.6995035807291666}, {"start": 2617.33, "end": 2617.83, "word": " هذه", "probability": 0.3408203125}, {"start": 2617.83, "end": 2618.17, "word": " الـ", "probability": 0.41064453125}, {"start": 2618.17, "end": 2618.33, "word": " L2", "probability": 0.5821533203125}, {"start": 2618.33, "end": 2619.03, "word": " بالمناسبة", "probability": 0.96455078125}, {"start": 2619.03, "end": 2619.51, "word": " لأنه", "probability": 0.720947265625}, {"start": 2619.51, "end": 2619.87, "word": " في", "probability": 0.8740234375}, {"start": 2619.87, "end": 2620.17, "word": " خلايا", "probability": 0.9475911458333334}, {"start": 2620.17, "end": 2620.53, "word": " كبيرة", "probability": 0.9811197916666666}, {"start": 2620.53, "end": 2620.93, "word": " وخلايا", "probability": 0.9237060546875}, {"start": 2620.93, "end": 2621.39, "word": " صغيرة", "probability": 0.9934895833333334}, {"start": 2621.39, "end": 2621.93, "word": " في", "probability": 0.74951171875}, {"start": 2621.93, "end": 2622.55, "word": " evacuation", "probability": 0.3740234375}, {"start": 2622.55, "end": 2623.17, "word": " في", "probability": 0.95751953125}, {"start": 2623.17, "end": 2624.21, "word": " الcytoplasm", "probability": 0.726220703125}, {"start": 2624.21, "end": 2624.67, "word": " و", "probability": 0.78662109375}, {"start": 2624.67, "end": 2625.15, "word": " still", "probability": 0.27783203125}, {"start": 2625.15, "end": 2625.45, "word": " the", "probability": 0.7314453125}, {"start": 2625.45, "end": 2626.09, "word": " cytoplasm", "probability": 0.9136962890625}, {"start": 2626.09, "end": 2626.31, "word": " is", "probability": 0.75634765625}, {"start": 2626.31, "end": 2626.61, "word": " purple", "probability": 0.89453125}, {"start": 2626.61, "end": 2626.87, "word": " in", "probability": 0.89208984375}, {"start": 2626.87, "end": 2627.19, "word": " color", "probability": 0.85498046875}], "temperature": 1.0}, {"id": 105, "seek": 264055, "start": 2628.47, "end": 2640.55, "text": "بهيك نكون غطينا طبعا الـ Acute Leukemia جوان تكونوا قفتوا من هذه المحاضرة و شكرا لكم", "tokens": [3555, 3224, 1829, 4117, 8717, 30544, 32771, 9566, 1829, 8315, 23032, 3555, 3615, 995, 2423, 39184, 5097, 1169, 1456, 15420, 29958, 10874, 2407, 7649, 6055, 30544, 14407, 12174, 5172, 2655, 14407, 9154, 29538, 9673, 5016, 46958, 25720, 4032, 13412, 4117, 23557, 5296, 24793], "avg_logprob": -0.4399857940998944, "compression_ratio": 1.1965811965811965, "no_speech_prob": 1.5676021575927734e-05, "words": [{"start": 2628.47, "end": 2628.89, "word": "بهيك", "probability": 0.5147247314453125}, {"start": 2628.89, "end": 2629.21, "word": " نكون", "probability": 0.537109375}, {"start": 2629.21, "end": 2629.67, "word": " غطينا", "probability": 0.9495849609375}, {"start": 2629.67, "end": 2630.03, "word": " طبعا", "probability": 0.7869873046875}, {"start": 2630.03, "end": 2630.19, "word": " الـ", "probability": 0.308837890625}, {"start": 2630.19, "end": 2630.39, "word": " Acute", "probability": 0.80810546875}, {"start": 2630.39, "end": 2630.89, "word": " Leukemia", "probability": 0.8885091145833334}, {"start": 2630.89, "end": 2631.27, "word": " جوان", "probability": 0.4318440755208333}, {"start": 2631.27, "end": 2631.83, "word": " تكونوا", "probability": 0.8548177083333334}, {"start": 2631.83, "end": 2633.33, "word": " قفتوا", "probability": 0.68853759765625}, {"start": 2633.33, "end": 2634.25, "word": " من", "probability": 0.92919921875}, {"start": 2634.25, "end": 2636.03, "word": " هذه", "probability": 0.58154296875}, {"start": 2636.03, "end": 2638.03, "word": " المحاضرة", "probability": 0.9617919921875}, {"start": 2638.03, "end": 2638.97, "word": " و", "probability": 0.63232421875}, {"start": 2638.97, "end": 2639.83, "word": " شكرا", "probability": 0.8543294270833334}, {"start": 2639.83, "end": 2640.55, "word": " لكم", "probability": 0.894287109375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2640.851875, "duration_after_vad": 2533.461249999991}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/P1BpBFbn3ds_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/P1BpBFbn3ds_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b727a307d283098371058a86b48bfbd5e7f5e1ae
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/P1BpBFbn3ds_raw.srt
@@ -0,0 +1,680 @@
+1
+00:00:01,840 --> 00:00:07,240
+بسم الله الرحمن الرحيم استكملا لمحاضرة ال non
+
+2
+00:00:07,240 --> 00:00:11,300
+-lochemical malignant myeloproliferative disorders
+
+3
+00:00:11,300 --> 00:00:16,820
+وصلنا لغاية ال primary thrombocythemia و أيضا لو
+
+4
+00:00:16,820 --> 00:00:18,880
+بنينا على التعريف الأول فال primary
+
+5
+00:00:18,880 --> 00:00:21,200
+thrombocythemia هي عبارة عن malignant clonal
+
+6
+00:00:21,200 --> 00:00:25,260
+disorders بيتميز بوجود مجاري megakaryocytic
+
+7
+00:00:25,260 --> 00:00:30,640
+hyperplasia في البولمارووهذا بينعكس على زيادة في
+
+8
+00:00:30,640 --> 00:00:34,320
+circulating platelet count ال primary
+
+9
+00:00:34,320 --> 00:00:38,620
+thrombocythemia لها أسماء أخرى بيسموها essential
+
+10
+00:00:38,620 --> 00:00:41,680
+thrombocythemia بيسموها idiopathic thrombocythemia
+
+11
+00:00:41,680 --> 00:00:47,980
+و بيسموها primary hemorrhagic thrombocythemia ال
+
+12
+00:00:47,980 --> 00:00:54,520
+incidence it's
+
+13
+00:00:54,520 --> 00:00:59,230
+rare in children and young adultsوالـ median age
+
+14
+00:00:59,230 --> 00:01:06,650
+is 60 years والـ men and women have equal
+
+15
+00:01:06,650 --> 00:01:12,810
+frequency pathophysiology طبعا زيادة ال platelet
+
+16
+00:01:12,810 --> 00:01:17,650
+بالشكل هذا بعمل increase thromboembolism و
+
+17
+00:01:17,650 --> 00:01:22,010
+increase hemorrhage لأن ال platelet مش شغالة و
+
+18
+00:01:22,010 --> 00:01:25,110
+أيضا splenomegaly لأنه فيه extra medullary
+
+19
+00:01:25,110 --> 00:01:30,550
+hemopoiesisفي أكتر من 80% من المرضى وهي مرات بيكون
+
+20
+00:01:30,550 --> 00:01:37,610
+فيه hepatomegaly ال clinical feature طبعا
+
+21
+00:01:37,610 --> 00:01:40,950
+أول حاجة الموجود في زيادة في ال platelet بتوصل في
+
+22
+00:01:40,950 --> 00:01:44,830
+بعض المرضى الى عشر مليون platelet عند الشخص انتوا
+
+23
+00:01:44,830 --> 00:01:50,090
+عارفين ال normal value هي لا تتجاوز ال 150 ل450
+
+24
+00:01:50,090 --> 00:01:56,290
+الف plateletالشيء الثاني هو بيصير فيه platelet
+
+25
+00:01:56,290 --> 00:02:03,390
+crumpling و بيصير فيه shape غير طبيعية
+
+26
+00:02:03,390 --> 00:02:09,890
+ثم مارت دي platelet variation في الشكل و فيه
+
+27
+00:02:09,890 --> 00:02:14,730
+fragment megakaryocytes الوقت blood cell بتزيد
+
+28
+00:02:14,730 --> 00:02:21,610
+لأنه فيه زيادة في الإنتاج ثم ال hemoglobin و ال
+
+29
+00:02:21,610 --> 00:02:26,980
+RBC's are normalفي iron deficiency إذا صار فيه
+
+30
+00:02:26,980 --> 00:02:32,240
+chronic hemorrhage و 25% من الحالات بيجلبوا إلى
+
+31
+00:02:32,240 --> 00:02:35,560
+myelofibrosis أو primary proliferative
+
+32
+00:02:35,560 --> 00:02:42,880
+polycythemia أو حتى acute non lymphoplastic
+
+33
+00:02:42,880 --> 00:02:48,260
+leukemia وهذا شكل ال blood film زي ما انتوا شايفين
+
+34
+00:02:48,260 --> 00:02:51,100
+فيه platelet بكميات كبيرة و فيه platelet clumping
+
+35
+00:02:53,600 --> 00:03:00,900
+Treatment في الغالب May Not Require Treatment لكن
+
+36
+00:03:00,900 --> 00:03:05,180
+بيعملولهم Platelet Aphoresis يعني بيعملوا
+
+37
+00:03:05,180 --> 00:03:09,420
+debulking لل Platelet وفي بعض الأحيان بيعطوا ال
+
+38
+00:03:09,420 --> 00:03:13,020
+creating agent زي المال فلان و البوصة الفان و
+
+39
+00:03:13,020 --> 00:03:16,780
+بيعطوا Heparin و Warfarin و هذين انتقالات انتقالات
+
+40
+00:03:16,780 --> 00:03:18,460
+انتقالات انتقالات انتقالات انتقالات انتقالات
+
+41
+00:03:18,460 --> 00:03:25,720
+انتقالاتأسبيرين بنعته as a prophylactic treatment
+
+42
+00:03:25,720 --> 00:03:31,860
+البروغنوزز ميديا سيرفايفل تايم حوالي عشر سنوات و
+
+43
+00:03:31,860 --> 00:03:34,760
+ال disease of course البروغنوزز خمسة و عشرين في
+
+44
+00:03:34,760 --> 00:03:37,560
+المية developed myelofibrosis كتلكيميا
+
+45
+00:03:37,560 --> 00:03:41,160
+transformation and this usually due to
+
+46
+00:03:41,160 --> 00:03:47,400
+cardiovascular complications ال
+
+47
+00:03:49,310 --> 00:03:51,730
+حالة المرضية التالتة او المرض التالت هو
+
+48
+00:03:51,730 --> 00:03:58,310
+Myelofibrosis هو عبارة عن Myelofibrosis من الاسم
+
+49
+00:03:58,310 --> 00:04:03,910
+فيه fibrosis في البون مارو و this is predominantly
+
+50
+00:04:03,910 --> 00:04:10,610
+a disease of the middle-aged and elderly وبيتميز
+
+51
+00:04:10,610 --> 00:04:14,590
+بالآتي progressive collagen fibrosis of the bone
+
+52
+00:04:14,590 --> 00:04:20,050
+marrow يعني ال bone marrow is fibroidوهي في ميجا
+
+53
+00:04:20,050 --> 00:04:25,210
+كاريوسيتك هايبريبلاجيا ميجا كاريوسايت بكميات كبيرة
+
+54
+00:04:25,210 --> 00:04:28,470
+جدا نسبين اوميجا ايه؟ لأنه فيه اكسترا ميدالري
+
+55
+00:04:28,470 --> 00:04:31,460
+هيماتو بويسيا طبيعي جدامدى ان هناك hyperplasia
+
+56
+00:04:31,460 --> 00:04:37,080
+ميجا كاريوستيكية معناه ان البون مارو صار له احتلال
+
+57
+00:04:37,080 --> 00:04:41,880
+بالميجا كاريو سايتس على حساب الخلايا الأخرى البون
+
+58
+00:04:41,880 --> 00:04:44,680
+مارو بيحاول ينتج او الجسم بيحاول ينتج خلايا
+
+59
+00:04:44,680 --> 00:04:50,020
+فبالتالي يرجع الى الاكستراميدالاريهيموبويسس المجلة
+
+60
+00:04:50,020 --> 00:04:55,420
+في ال process بيصيب ال male و ال female equally
+
+61
+00:04:55,420 --> 00:04:56,920
+pathophysiology
+
+62
+00:05:00,240 --> 00:05:04,660
+Lethargy وExercise Intolerance وSecondary to
+
+63
+00:05:04,660 --> 00:05:08,680
+Anemia كون عنده أنيميا فبالتالي هذه مظاهر الانيميا
+
+64
+00:05:08,680 --> 00:05:12,440
+ثم Weight Loss وNight Sweating وSecondary to
+
+65
+00:05:12,440 --> 00:05:15,840
+Metabolic Disturbances زي ما بيحصل في حي حالة
+
+66
+00:05:15,840 --> 00:05:21,720
+ملجنانسي بيحصل فيه زيادة في ال Metabolic Rate
+
+67
+00:05:21,720 --> 00:05:26,660
+وبالتالي بيحصل فيه Night Sweating وفقدان للوزنالـ
+
+68
+00:05:26,660 --> 00:05:30,560
+bruising لأن الـ platelet is not functioning و
+
+69
+00:05:30,560 --> 00:05:36,660
+بيسموه left sided patient لإنه ال abdomen جاي على
+
+70
+00:05:36,660 --> 00:05:42,020
+الشجة الشمال نتيجة ال massive splenomegaly اللي
+
+71
+00:05:42,020 --> 00:05:46,240
+بيصير عنده نتيجة ال extra medullary hemopoiesis في
+
+72
+00:05:46,240 --> 00:05:49,980
+هذه الحالة ال bone marrow لما بتليف بيركن بيعتمد
+
+73
+00:05:49,980 --> 00:05:53,940
+اعتماد كله على ال spleen ك extra medullary organ
+
+74
+00:05:58,110 --> 00:06:02,450
+الـ Extra-medullary hemopoiesis في اللفر ايضا ممكن
+
+75
+00:06:02,450 --> 00:06:07,430
+تحصل Greatly increased bone marrow density with
+
+76
+00:06:07,430 --> 00:06:10,150
+narrowing of the medullary cavity
+
+77
+00:06:14,460 --> 00:06:18,960
+وبالتالي بتقل ال bone .. بتزيد ال bone density و
+
+78
+00:06:18,960 --> 00:06:25,340
+بي .. بي .. بي .. بي .. بي .. بيصير في narrowing ل
+
+79
+00:06:25,340 --> 00:06:32,720
+المدلغ ال cavity يعني من جوا بيصير في مدلغ
+
+80
+00:06:32,720 --> 00:06:36,980
+ال cavity يعني الفراغ اللي داخل ال bone بيمتلي بال
+
+81
+00:06:36,980 --> 00:06:40,240
+fiber و يبتشر وبالتالي ال density بتزيد لكن فيش
+
+82
+00:06:40,240 --> 00:06:45,110
+إنتاجكما تشاهدون كمية الـSpleen كمية كبيرة من
+
+83
+00:06:45,110 --> 00:06:48,490
+الـSpleen كل المنطقة هذه عبارة عن الـSpleen
+
+84
+00:06:48,490 --> 00:06:51,750
+لبرايرتري
+
+85
+00:06:51,750 --> 00:06:55,670
+فاينينج لو طلعنا على البريفيرات blood smear سيكون
+
+86
+00:06:55,670 --> 00:07:00,110
+هناك اليوكو إريترو بلاستيك أنيميا وهو عبارة عن
+
+87
+00:07:00,110 --> 00:07:04,830
+أنيميا ناتجة عن ال
+
+88
+00:07:08,860 --> 00:07:15,000
+Yuco-Erythroplastic عن الـ Nucleated RBCs ماشي
+
+89
+00:07:15,000 --> 00:07:21,480
+لمخد أشكال الـ White BCs لأنها بتنزل الـ Nucleated
+
+90
+00:07:21,480 --> 00:07:28,280
+RBCs وفي prominent Polychromagia و Anisocytosis
+
+91
+00:07:28,280 --> 00:07:33,660
+تيريجروب و Perikilocytosis الوقت بيصل الـ Platelet
+
+92
+00:07:33,660 --> 00:07:38,650
+count على الvariable لكن في الغالب زيدهوكل ما تطور
+
+93
+00:07:38,650 --> 00:07:43,070
+المرض degree of dysplasia بتزيد يعني التشوهات
+
+94
+00:07:43,070 --> 00:07:48,830
+الخلايا بتزيد و circulating cell count markedly
+
+95
+00:07:48,830 --> 00:07:52,810
+decreased مفيش امتاج increase white blood cell
+
+96
+00:07:52,810 --> 00:07:57,590
+anarchy turnover leading to increase LDH طبعا هذه
+
+97
+00:07:57,590 --> 00:08:03,270
+الخلايا بتموت بدري وبالتالي تتكسر و بتموت فبيزيد
+
+98
+00:08:03,270 --> 00:08:06,950
+ال LDH بيزيد ال uric acid بيزيد ال isozymeفي
+
+99
+00:08:06,950 --> 00:08:12,690
+الحالات المتقدمة و تركيز ال serum of hepatic
+
+100
+00:08:12,690 --> 00:08:19,630
+enzyme أيضا بيكون abnormal ال يوكو إيريثرو بلاستيك
+
+101
+00:08:19,630 --> 00:08:24,030
+blood film زي ما انتوا شايفين فيه nucleated RBCs
+
+102
+00:08:24,030 --> 00:08:34,950
+موجودة في النص و ال RBCs is hypochromic
+
+103
+00:08:36,580 --> 00:08:42,800
+طبعا هناك بيكيو سايتوسز وانيسو سايتوسز فبصيرت يعني
+
+104
+00:08:42,800 --> 00:08:47,280
+هنا كتير دروب ع كتير و بزيد ال neutral alkaline
+
+105
+00:08:47,280 --> 00:08:52,300
+phosphatase score و these are abnormal بالنسبة
+
+106
+00:08:52,300 --> 00:08:54,740
+لالبون مارو، البون مارو في موضوع مهم جدا
+
+107
+00:08:57,350 --> 00:09:01,610
+وهو ظاهرة من الظواهر التشخيصية في هذه الحالة نبغى
+
+108
+00:09:01,610 --> 00:09:05,430
+واحد انه احنا و في failure to aspirate bone marrow
+
+109
+00:09:05,430 --> 00:09:10,610
+لأن ال bone marrow is fibroid فبتطلع ما يسمى ال
+
+110
+00:09:10,610 --> 00:09:17,570
+dry tab phenomena تطلع سحبة الإبرة فاضية ال bone
+
+111
+00:09:17,570 --> 00:09:22,810
+marrow smear reveal large patchy area بتلاقي لو
+
+112
+00:09:22,810 --> 00:09:30,270
+عملنابون مارو سمير هتلاقي فراغات من اللي هو ال
+
+113
+00:09:30,270 --> 00:09:36,550
+touch of the smear يعني حزم هيك فراغات في
+
+114
+00:09:36,550 --> 00:09:43,190
+cavacules في السمير نتيجة قلة إنتاج الخلايا وهذه
+
+115
+00:09:43,190 --> 00:09:46,490
+الفراغات مليانة بتكون بال this plastic
+
+116
+00:09:46,490 --> 00:09:51,230
+megakaryocytes these طبعا megakaryocytes die
+
+117
+00:09:51,230 --> 00:09:59,190
+within the bone مارووبت .. once died it will
+
+118
+00:09:59,190 --> 00:10:07,570
+release two thing two things الأولاني platelet
+
+119
+00:10:07,570 --> 00:10:13,950
+derived growth factor والتاني platelet factor 4 شو
+
+120
+00:10:13,950 --> 00:10:16,670
+وقفت كل واحد منهم قالوا ال platelet derived growth
+
+121
+00:10:16,670 --> 00:10:22,910
+factor is a fibroblast mitogen يعني بيزود إنتاج ال
+
+122
+00:10:22,910 --> 00:10:30,540
+fibroblastو Platelet Factor 4 أيضًا وظيفته Inhibit
+
+123
+00:10:30,540 --> 00:10:36,220
+neutrophil and fibroblast collagenase enzyme
+
+124
+00:10:36,220 --> 00:10:41,480
+فمافيش إذابة للـ Fiber اللي بتتكون يبقى الأولان
+
+125
+00:10:41,480 --> 00:10:47,560
+يبقى من ال fibroblast وبالتالي في Fiber Formation
+
+126
+00:10:49,430 --> 00:10:52,310
+المفروض أن يكون هناك كولاجينيز إنزايم تدوّي
+
+127
+00:10:52,310 --> 00:10:55,530
+بالـFibrosis اللي صار إلا إنه اللي بيطلع من
+
+128
+00:10:55,530 --> 00:10:58,810
+الـNitrophil والـFibroblast إلا إن هؤلاء
+
+129
+00:10:58,810 --> 00:11:03,410
+الكولاجينيز الإنزايم انهيبتد بـPlatelet Factor 4
+
+130
+00:11:03,410 --> 00:11:11,430
+تأثير التنين مع بعض بيزود الـCollagenous Fibrosis
+
+131
+00:11:11,430 --> 00:11:17,940
+في المعروف وهذا ما يميز هذه الحالةوبالتالي الـ
+
+132
+00:11:17,940 --> 00:11:21,480
+Myelofibrosis هو عبارة عن Secondary Phenomena in
+
+133
+00:11:21,480 --> 00:11:29,300
+Myelofibrosis و الـ Primary Defect بيقع في الـ
+
+134
+00:11:29,300 --> 00:11:31,700
+Hemopoietic Merginator Cell of Colon Reforming
+
+135
+00:11:31,700 --> 00:11:36,740
+Unit ميجا كاريوسايت و Colon Reforming Unit GM او
+
+136
+00:11:36,740 --> 00:11:38,060
+Granulocyte مروسايت
+
+137
+00:11:43,220 --> 00:11:48,500
+يعني الأساس هو الخلايا اللي برجينيت الcells of
+
+138
+00:11:48,500 --> 00:11:53,240
+megakaryocyte and granulocyte megakaryocyte these
+
+139
+00:11:53,240 --> 00:11:58,520
+cells are prominent
+
+140
+00:11:58,520 --> 00:12:02,280
+and die within the marrow وبالتالي هم اللي بيعملوا
+
+141
+00:12:02,280 --> 00:12:03,880
+fibrotic tissue في ال bone marrow
+
+142
+00:12:07,540 --> 00:12:13,000
+طبعاً this will increase hostility of the marrow
+
+143
+00:12:13,000 --> 00:12:16,740
+hemopoietic microenvironment promotes the
+
+144
+00:12:16,740 --> 00:12:19,160
+establishment of extramedullary hemopoiesis in the
+
+145
+00:12:19,160 --> 00:12:23,300
+fetal sides of the spleen and liver كون البون مارو
+
+146
+00:12:23,300 --> 00:12:28,640
+هذه الجملة بتقول كون البون مارو تليف و ال micro
+
+147
+00:12:28,640 --> 00:12:33,120
+environment of hemopoietic microenvironment has no
+
+148
+00:12:33,120 --> 00:12:38,860
+more hemopoieticالبروسيس بدّو يضطر الإنسان يلجأ
+
+149
+00:12:38,860 --> 00:12:41,720
+إلى الـ fetal site of hemopoiesis اللي هي اللي
+
+150
+00:12:41,720 --> 00:12:46,940
+يبقى عبارة عن الـ spleen و اللفر treatment لأول
+
+151
+00:12:46,940 --> 00:12:49,320
+مرضى من هالموعة بيعيشوا تلت سنوات ال medium age
+
+152
+00:12:49,320 --> 00:12:54,600
+اللي هم تلت سنوات بعد الحالة can survive for 10
+
+153
+00:12:54,600 --> 00:12:58,420
+years و حوار 10% منهم بيجربوا ل acute non
+
+154
+00:12:58,420 --> 00:13:05,520
+lymphoplastic leukemiaوغالبا في المال وعشان نعالجه
+
+155
+00:13:05,520 --> 00:13:10,320
+نعمل radiation to reduce the size of skin بيعملوا
+
+156
+00:13:10,320 --> 00:13:16,690
+radiation للتحالوبالتالي بيقللوا من حجمه وبالتالي
+
+157
+00:13:16,690 --> 00:13:23,030
+بي .. يعني بيقللوا من ال symptoms من المعاناة من
+
+158
+00:13:23,030 --> 00:13:29,450
+ال pain ماشي such as RBC's
+
+159
+00:13:29,450 --> 00:13:33,190
+or platelet sequestration في ال .. في ال spring
+
+160
+00:13:36,600 --> 00:13:43,100
+يوم ما نفشل فيه تصغير حجم الـSpleen بالردياشن
+
+161
+00:13:43,100 --> 00:13:49,160
+الـSpleenectomy هي الـ solution هي الحقيقة الحالة
+
+162
+00:13:49,160 --> 00:13:56,120
+حاجة تانية blood transfusion يوم ما يدخل المريض في
+
+163
+00:13:56,120 --> 00:14:00,100
+قانينه أندروجين عشان نعمل correction لـ
+
+164
+00:14:00,100 --> 00:14:06,230
+ineffective hemopoiesis hematenic therapyإذا كان
+
+165
+00:14:06,230 --> 00:14:10,850
+فيه Iron Orphrate Deficiency الـ Purinol هذا عبارة
+
+166
+00:14:10,850 --> 00:14:17,970
+عن علاج للـ Hyperuricemia ويوم يتطور المرض Rapidly
+
+167
+00:14:17,970 --> 00:14:22,330
+chemotherapy can be used والأمل الوحيد في علاج
+
+168
+00:14:22,330 --> 00:14:25,210
+مرضى من هذا النوع هو bone marrow transplantation
+
+169
+00:14:25,210 --> 00:14:33,250
+لكن in young ages بهيك بنكون أنهينا هذه المحاضرة
+
+170
+00:14:35,100 --> 00:14:37,660
+مشكر لكم حسن الاستماع
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..f4f0d1efd0754287cb9c020656a6d5b19222b6bb
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_postprocess.srt
@@ -0,0 +1,1160 @@
+1
+00:00:01,670 --> 00:00:06,830
+بسم الله الرحمن الرحيم نلتقي
+
+2
+00:00:06,830 --> 00:00:11,530
+اليوم أيضا في معادرة بعنوان the non-leukemic
+
+3
+00:00:11,530 --> 00:00:20,070
+malignant disorders by definition non-leukemic
+
+4
+00:00:20,070 --> 00:00:25,520
+malignant disordersبشكل أساسي بإنهم مجموعات مورفوس
+
+5
+00:00:25,520 --> 00:00:30,080
+و لينال ديس أورداز بيتميزوا بـ uncontrolled clonal
+
+6
+00:00:30,080 --> 00:00:33,400
+proliferation of bone marrow دلوقت سنة أي خلية من
+
+7
+00:00:33,400 --> 00:00:39,020
+خلايا البون مارور بلد سيلولار اللي موجودة في البون
+
+8
+00:00:39,020 --> 00:00:41,560
+مارور بسللها abnormal clonal proliferation
+
+9
+00:00:41,560 --> 00:00:46,200
+وبالتالي بزيد عددها زيادة مهولة Classification
+
+10
+00:00:46,200 --> 00:00:50,350
+قسموها إلى أنواعينمالكنا نتمييله proliferative
+
+11
+00:00:50,350 --> 00:00:54,130
+disorders وهدى بتشمل primary proliferative
+
+12
+00:00:54,130 --> 00:00:58,590
+polycythemia و primary thrombocythemia و
+
+13
+00:00:58,590 --> 00:01:01,070
+myelofibrosis و احنا هنتطرق اليهم ان شاء الله
+
+14
+00:01:01,070 --> 00:01:04,510
+بالتفصيل ثم المالكنا نتلمفه proliferative
+
+15
+00:01:04,510 --> 00:01:11,330
+disorders و اختارنالكم multiple myeloma and
+
+16
+00:01:11,330 --> 00:01:15,130
+related plasma cell disorders ثم Hodgkin disease و
+
+17
+00:01:15,130 --> 00:01:16,190
+non Hodgkin lymphoma
+
+18
+00:01:18,750 --> 00:01:22,890
+ونبدأ بالـ Myeloproliferative non-leukemic
+
+19
+00:01:22,890 --> 00:01:27,770
+myeloproliferative disorders واتفقنا على أن هذا
+
+20
+00:01:27,770 --> 00:01:32,390
+عبارة عن hemipietic stem cell disorders انه كلونل
+
+21
+00:01:32,390 --> 00:01:36,810
+وتميز بوجود granulocytic و erythrocytic و
+
+22
+00:01:36,810 --> 00:01:45,110
+megakaryocytic increase تلاتة بصير لهم abnormal
+
+23
+00:01:45,110 --> 00:01:49,100
+clonal proliferationموجود هو انه فيه inter
+
+24
+00:01:49,100 --> 00:01:54,960
+relation between this increase and their diseases
+
+25
+00:01:54,960 --> 00:02:00,540
+فعلى سبيل المثال RBCs بيسموها polycythemia
+
+26
+00:02:00,540 --> 00:02:04,740
+platelet بيسموها central thrombocythemia ثم ال
+
+27
+00:02:04,740 --> 00:02:11,980
+myelofibrosis هو عبارة عن fibrosis نتيجة ال mega
+
+28
+00:02:11,980 --> 00:02:16,350
+karyocytic abnormalclonal proliferation of
+
+29
+00:02:16,350 --> 00:02:22,390
+megakaryocytic proliferation
+
+30
+00:02:22,390 --> 00:02:27,970
+طبعا هى زى ما انتوا شايفين هى عبارة عن ال استيبواز
+
+31
+00:02:27,970 --> 00:02:32,290
+ال progression of to fibrosis to marrow failure or
+
+32
+00:02:32,290 --> 00:02:35,590
+acute blast phase زى ما انتوا شايفين هى ال bone
+
+33
+00:02:35,590 --> 00:02:41,750
+marrow stem cell اكتسبت meditation ال abnormal و
+
+34
+00:02:41,750 --> 00:02:47,550
+required abnormalityفالتأثر طبعا لجرانيولوستيك وال
+
+35
+00:02:47,550 --> 00:02:50,810
+RBCs والميجاكاريوستيك لأننا بنحكي على
+
+36
+00:02:50,810 --> 00:02:55,650
+myeloproliferase جرانيولوستيك لما صار هكلونا ال
+
+37
+00:02:55,650 --> 00:03:01,710
+proliferation أدتنا chronic myeloid leukemia و ال
+
+38
+00:03:01,710 --> 00:03:08,860
+RBCs precursor أدى polycythemia أو Robraviraوالـ
+
+39
+00:03:08,860 --> 00:03:12,940
+Megakaryocytes is the essential thrombocythemia
+
+40
+00:03:12,940 --> 00:03:18,640
+which can transform to reactive fibrosis وبتكون
+
+41
+00:03:18,640 --> 00:03:24,400
+الاش ميلوفيبروسيس ولاحظوا العلاقة ما بين هذه
+
+42
+00:03:24,400 --> 00:03:29,310
+الأمراض وما بين ال acute myeloid leukemia فجالواان
+
+43
+00:03:29,310 --> 00:03:33,030
+ال chronic myeloid leukemia 70% منها بيجلب ل acute
+
+44
+00:03:33,030 --> 00:03:37,610
+myeloid leukemia polycythemia 10% منها بيجلب ل
+
+45
+00:03:37,610 --> 00:03:41,190
+acute myeloid leukemia central thrombocythemia
+
+46
+00:03:41,190 --> 00:03:47,890
+sorry polycythemia أيضا ممكن تتحول ل myelofibrosis
+
+47
+00:03:47,890 --> 00:03:53,370
+30% منها و ال myelofibrosis ممكن 10% منه يصير
+
+48
+00:03:53,370 --> 00:04:00,060
+acute myeloid leukemia ففي انترrelation between
+
+49
+00:04:00,060 --> 00:04:07,020
+these disorders نبدأ بأول هذه الانواع ال primary
+
+50
+00:04:07,020 --> 00:04:11,810
+proliferate polycythemiaالتي تسمى Malignant
+
+51
+00:04:11,810 --> 00:04:15,710
+disorders وفيهم بيوتكس تمثال And it's
+
+52
+00:04:15,710 --> 00:04:18,550
+characterized by absolute erythrocytosis يبقى
+
+53
+00:04:18,550 --> 00:04:23,390
+بماذا يتميز؟ يتميز by absolute erythrocytosis
+
+54
+00:04:23,390 --> 00:04:27,390
+وطبعا لأن الأم واحدة فبصير في مدلة ال increase
+
+55
+00:04:27,390 --> 00:04:34,070
+لجرانيو و ال count و ال platelet ممكن تيجي للإنسان
+
+56
+00:04:34,070 --> 00:04:42,500
+في أي عمرالخطوة المسلحة هي عمر الشباب في بيبول عمر
+
+57
+00:04:42,500 --> 00:04:48,440
+الشباب في بيبول هو حوالي 55 سنة الملابس يتأثرون
+
+58
+00:04:48,440 --> 00:04:51,620
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+59
+00:04:51,620 --> 00:04:54,820
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+60
+00:04:54,820 --> 00:04:55,060
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+61
+00:04:55,060 --> 00:04:55,360
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+62
+00:04:55,360 --> 00:04:56,140
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+63
+00:04:56,140 --> 00:04:56,960
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+64
+00:04:56,960 --> 00:05:07,190
+بشكل اكتر من الشبالتي تتعامل بشكل اتانومس في الـ
+
+65
+00:05:07,190 --> 00:05:10,510
+abnormal decline الـ
+
+66
+00:05:10,510 --> 00:05:15,910
+disease phases قالوا فيه تلاتة phases غالبا
+
+67
+00:05:15,910 --> 00:05:21,030
+proliferative phase ثم spent او post polycyathemic
+
+68
+00:05:21,030 --> 00:05:26,090
+phase وقلنا rarely transformed into acute leukemia
+
+69
+00:05:26,090 --> 00:05:27,150
+فهذا phase تالت
+
+70
+00:05:30,380 --> 00:05:34,420
+recognition of polycythemia قالوا ال recognition
+
+71
+00:05:34,420 --> 00:05:37,940
+by measuring ال back cell volume او ال hematocrit
+
+72
+00:05:37,940 --> 00:05:41,540
+وجدوا ان ال male المفروض يكون اكتر من واحد و خمسين
+
+73
+00:05:41,540 --> 00:05:51,140
+و ال female اكتر من تمانية و ربعين و التغير
+
+74
+00:05:51,140 --> 00:05:56,060
+في ال PCB ممكن يكون له سبب اخر وهو ال reduction in
+
+75
+00:05:56,060 --> 00:06:04,340
+plasma اوTrue increase in RBCs number يبقى هذه
+
+76
+00:06:04,340 --> 00:06:11,680
+أسباب ال polycythemia Classification قسموها لنوعين
+
+77
+00:06:11,680 --> 00:06:16,640
+أساسيين جاله ال absolute أو بيسمى true و ال true
+
+78
+00:06:16,640 --> 00:06:21,370
+بتشمل primary proliferate polycythemiaاللي احنا
+
+79
+00:06:21,370 --> 00:06:24,830
+تاول حكينا عنها ثم secondary polycythemia
+
+80
+00:06:24,830 --> 00:06:29,730
+وidiopathic erythrocytosis for unknown reason
+
+81
+00:06:29,730 --> 00:06:34,150
+بتلاقي ال RBC's عالية نوع التاني من ال
+
+82
+00:06:34,150 --> 00:06:37,770
+polycythemia هو ال apparent or relative وهذه
+
+83
+00:06:37,770 --> 00:06:45,870
+نتيجات البلازما volume or RBC's mass changes نرجع
+
+84
+00:06:45,870 --> 00:06:49,690
+لل
+
+85
+00:06:53,560 --> 00:06:58,280
+absolute لأسباب الـabsolute polycythemia قالوا
+
+86
+00:06:58,280 --> 00:07:02,000
+الـmalignant transformation بيخلّي ال hemopoietic
+
+87
+00:07:02,000 --> 00:07:06,060
+stem cell to be free from hormonal control
+
+88
+00:07:06,060 --> 00:07:09,080
+وبالتالي
+
+89
+00:07:09,080 --> 00:07:13,640
+لا تتأثر بتغير الهرمون اللي هو الارتروبيتينهرمون
+
+90
+00:07:13,640 --> 00:07:16,680
+عشان هيك الارتروبيتينهرمون is decreased في هذه
+
+91
+00:07:16,680 --> 00:07:21,920
+الحالات hypoxic effect has no effect
+
+92
+00:07:26,580 --> 00:07:31,220
+فيزيولوجيا ممكن ان يكون هناك استميلات غير مناسبة
+
+93
+00:07:31,220 --> 00:07:31,700
+أو استميلات غير مناسبة أو استميلات غير مناسبة او
+
+94
+00:07:31,700 --> 00:07:33,000
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+95
+00:07:33,000 --> 00:07:34,620
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+96
+00:07:34,620 --> 00:07:35,400
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+97
+00:07:35,400 --> 00:07:37,940
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+98
+00:07:37,940 --> 00:07:39,420
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+99
+00:07:39,420 --> 00:07:40,900
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+100
+00:07:40,900 --> 00:07:44,740
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+101
+00:07:44,740 --> 00:07:52,400
+استميلات غير مناسباللي abnormal ال primary
+
+102
+00:07:52,400 --> 00:07:56,480
+proliferative polycythemia and this is a malignant
+
+103
+00:07:56,480 --> 00:08:05,900
+disorder لكن الفهم أنواع ال polycythemia بالكامل
+
+104
+00:08:05,900 --> 00:08:10,760
+هو عبارة عن ضرورةلأن الـ recognition of primary
+
+105
+00:08:10,760 --> 00:08:15,400
+progressive prosethemia is based on exclusion
+
+106
+00:08:29,780 --> 00:08:38,120
+بينلي ال classification of polycythemia اي
+
+107
+00:08:38,120 --> 00:08:43,940
+polycythemia vera او ال PCV تكون عالية اسمها ال
+
+108
+00:08:43,940 --> 00:08:48,920
+absolute او بيسموه true و ان هذا بيحتوي على نوعين
+
+109
+00:08:48,920 --> 00:08:53,200
+نوع الأولاني بيسموه primaryو الارتروبيوتين فيه
+
+110
+00:08:53,200 --> 00:08:59,220
+بيكون decreased و النوع التاني هو ال secondary
+
+111
+00:08:59,220 --> 00:09:03,460
+والارتروبيوتين فيه بيكون عالي بالنسبة لل secondary
+
+112
+00:09:03,460 --> 00:09:06,660
+اللي بيبقى الارتروبيوتين فيه عالي زيادة
+
+113
+00:09:06,660 --> 00:09:09,340
+الارتروبيوتين ممكن تكون due to appropriate cause
+
+114
+00:09:09,340 --> 00:09:12,700
+or inappropriate cause فال appropriate cause زي ال
+
+115
+00:09:12,700 --> 00:09:18,510
+attitude هذا واضح طبيعيزي الـ Cardiopulmonary برضه
+
+116
+00:09:18,510 --> 00:09:22,790
+و ده طبيعي زي ال smoking بيقدّي الى زيادة
+
+117
+00:09:22,790 --> 00:09:26,150
+الارتروبيوتين و لما appropriate وجود cancer او
+
+118
+00:09:26,150 --> 00:09:31,810
+tumor او even cyst بعيدة عن الاسوأن كان في الكدن
+
+119
+00:09:31,810 --> 00:09:38,330
+ولا زي renal ولا extra renal tumor هذا بيحفظ على
+
+120
+00:09:38,330 --> 00:09:43,110
+إنتاج الارتروبيوتينما التاني من الـ polycythemia
+
+121
+00:09:43,110 --> 00:09:45,630
+هو الـ apparent اللي يكون في الـ red cell mass
+
+122
+00:09:45,630 --> 00:09:49,450
+could be normal لكن due to hydration or stress or
+
+123
+00:09:49,450 --> 00:09:54,630
+smoking بيبدأ يحصل فيه زيادة نسبية لل RBCs mass
+
+124
+00:09:54,630 --> 00:10:03,010
+بالنسبة لل plasma secondary polycythemia usually
+
+125
+00:10:03,010 --> 00:10:10,260
+due to known causes وقالوا في منهانوعين كمبنساتوري
+
+126
+00:10:10,260 --> 00:10:14,440
+انكريز في الارتروبيوتين او appropriate release of
+
+127
+00:10:14,440 --> 00:10:17,640
+arteropoietin زي في حالة ال high attitude
+
+128
+00:10:17,640 --> 00:10:21,280
+pulmonary disease heart disease زي ال cyanotic
+
+129
+00:10:21,280 --> 00:10:24,460
+heart disease abnormal hemoglobin high affinity
+
+130
+00:10:24,460 --> 00:10:28,060
+hemoglobin heavy cigarette smokers كل هذه عبارة عن
+
+131
+00:10:28,060 --> 00:10:31,620
+أسباب و حالات مرضية بيصير فيها appropriate or
+
+132
+00:10:31,620 --> 00:10:36,190
+compensatory increase in arteropoietinالنوع التاني
+
+133
+00:10:36,190 --> 00:10:39,310
+اللي هو appropriate erythropoietin production يوم
+
+134
+00:10:39,310 --> 00:10:43,530
+زي ما قلنا يكون فيه tumor سواء كان رينال ولا
+
+135
+00:10:43,530 --> 00:10:50,490
+فيبروميونة موجودة في extra-renal او hydronephrosis
+
+136
+00:10:50,490 --> 00:10:54,730
+في الرينال و liver carcinoma extra-renal و هكذا
+
+137
+00:10:54,730 --> 00:11:00,970
+دول كلهم عبارة عن cancers بيؤدوا بيحفظوا على تصنيع
+
+138
+00:11:00,970 --> 00:11:06,050
+ال erythropoietin بس دون الحاجة لهوبالتالي يزيد
+
+139
+00:11:06,050 --> 00:11:11,530
+الارثروبياتين نسبياً Caused physiological
+
+140
+00:11:11,530 --> 00:11:14,410
+appropriate release of arithopoietin
+
+141
+00:11:14,410 --> 00:11:17,170
+وPhysiologically inappropriate release of
+
+142
+00:11:17,170 --> 00:11:21,970
+arithopoietin الفيزيولوجيكي اترابيت ايه ريليز
+
+143
+00:11:21,970 --> 00:11:27,570
+الارثروبياتين يعني اسبابها كالعادية السبب الأولاني
+
+144
+00:11:27,570 --> 00:11:30,170
+ان يكون الارثروبياتين مستمرين في اتماسك اكسجين
+
+145
+00:11:30,170 --> 00:11:33,790
+تنشئ انت جاعد في مكان مافيش فيه اكسجينزي ما يحصل
+
+146
+00:11:33,790 --> 00:11:39,490
+في الـ high altitude السبب التاني هو in adequate
+
+147
+00:11:39,490 --> 00:11:44,770
+uptake of atmospheric oxygen فيه أكسجين بس انت
+
+148
+00:11:44,770 --> 00:11:48,690
+مابتاخده بالكميات المقلوبة زي ال chronic
+
+149
+00:11:48,690 --> 00:11:52,170
+bronchitis ايه الفيزياما بلموناري فيبروسيز
+
+150
+00:11:52,170 --> 00:11:56,750
+بلموناري اديما هذا سبب شائع فكرة كتير يبقى الأولان
+
+151
+00:11:56,750 --> 00:11:59,410
+ان انت قاعد في جوء مافيش فيه أكسجين تاني فيه
+
+152
+00:11:59,410 --> 00:12:05,420
+أكسجينلكن ما بتعرف تاخده او تاخده inadequately سبب
+
+153
+00:12:05,420 --> 00:12:11,480
+تالت انه في اكسوجين انت جاعد في جو فيه اكسوجين و
+
+154
+00:12:11,480 --> 00:12:16,920
+بتاخد الاكسوجين appropriately او adequately لكن
+
+155
+00:12:16,920 --> 00:12:19,660
+بيصير فيه defect في ال transport of absorbed
+
+156
+00:12:19,660 --> 00:12:25,080
+oxygen from the lung وهذا ممكن يصير في variety of
+
+157
+00:12:25,080 --> 00:12:28,400
+inherited or acquired defect of hemoglobin
+
+158
+00:12:28,400 --> 00:12:33,460
+functionالمشكلة المتابلية التي تقلل إدارة
+
+159
+00:12:33,460 --> 00:12:36,940
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+160
+00:12:36,940 --> 00:12:39,140
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+161
+00:12:39,140 --> 00:12:39,560
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+162
+00:12:39,560 --> 00:12:40,340
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+163
+00:12:40,340 --> 00:12:42,480
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+164
+00:12:42,480 --> 00:12:44,720
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+165
+00:12:44,720 --> 00:12:47,360
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+166
+00:12:47,360 --> 00:12:51,140
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+167
+00:12:51,140 --> 00:12:57,700
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتالـ
+
+168
+00:12:57,700 --> 00:12:59,800
+Physiologically Inappropriate Release of
+
+169
+00:12:59,800 --> 00:13:04,380
+erythropoietin فيه variety of disorders associated
+
+170
+00:13:04,380 --> 00:13:06,640
+with inappropriate release of erythropoietin
+
+171
+00:13:06,640 --> 00:13:11,960
+occurs as a rare complication of renal disorders
+
+172
+00:13:11,960 --> 00:13:16,380
+زي polycystic kidney, chronic lumbar nephritis,
+
+173
+00:13:16,600 --> 00:13:24,310
+hydronephrosis, renal tumorAn extrarenal tumor زي
+
+174
+00:13:24,310 --> 00:13:27,910
+الهيباطومة والبرونكيل الكارسينومة كلها عبارة عن
+
+175
+00:13:27,910 --> 00:13:34,430
+حالات مرضية بتخلق الواحد المريضي to release the
+
+176
+00:13:34,430 --> 00:13:38,370
+erythropoietin inappropriately هاي ال secondary
+
+177
+00:13:38,370 --> 00:13:41,290
+prostatemia برضه حالات مرضية زي ال arterial blood
+
+178
+00:13:41,290 --> 00:13:48,690
+gasعشان تشخص ال secondary polycythemia بدك تعمل
+
+179
+00:13:48,690 --> 00:13:54,410
+الفعوصات القاتية نمرة واحد arterial blood gas نمرة
+
+180
+00:13:54,410 --> 00:13:58,550
+اتنين hemoglobin electrophoresis نمرة تلاتة oxygen
+
+181
+00:13:58,550 --> 00:14:03,050
+dissociation care نمرة اربعة erythropoietin level
+
+182
+00:14:03,050 --> 00:14:08,990
+خمسة ultrasound abdomen and chest x-ray بعدين
+
+183
+00:14:08,990 --> 00:14:15,340
+total insulin volume تشوفوا ثابت ولا لأby labeling
+
+184
+00:14:15,340 --> 00:14:20,820
+the RBCs by Chromium 51 وهي Total Plasma Volume
+
+185
+00:14:20,820 --> 00:14:27,540
+ايضا by labeling by one Iodine 125 مرتبط
+
+186
+00:14:27,540 --> 00:14:31,360
+بالالبومين
+
+187
+00:14:31,360 --> 00:14:36,320
+الـ
+
+188
+00:14:36,320 --> 00:14:40,480
+Appropriate Procythemia rather than defined as
+
+189
+00:14:40,480 --> 00:14:40,720
+those
+
+190
+00:15:01,850 --> 00:15:06,930
+أو باستخدام مجموعات الرسمية الروحانية الروحانية
+
+191
+00:15:06,930 --> 00:15:10,910
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+192
+00:15:10,910 --> 00:15:10,990
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+193
+00:15:10,990 --> 00:15:12,490
+الروحانية الروحانية الروحانية الروحانية الروحانيةو
+
+194
+00:15:12,490 --> 00:15:16,730
+ال بي بي towards the lower limit of normality يعني
+
+195
+00:15:16,730 --> 00:15:20,830
+هدا كيصل على ال lower limit اللي ما تقريت و هدا
+
+196
+00:15:20,830 --> 00:15:25,830
+كيصل لبلاسما على ال upper limit of ash of بلاسما
+
+197
+00:15:25,830 --> 00:15:29,210
+اجراء البروسيثيميا is by far the most common
+
+198
+00:15:29,210 --> 00:15:36,650
+finding where ال PCB is only minimally increased و
+
+199
+00:15:36,650 --> 00:15:41,730
+بشكل حقبيكون أو بيصل لغاية خمسين فمية of such
+
+200
+00:15:41,730 --> 00:15:45,550
+cases alternative names of this condition include
+
+201
+00:15:45,550 --> 00:15:47,990
+relative polycythemia, solid polycythemia,
+
+202
+00:15:48,110 --> 00:15:53,250
+stressed polycythemia and sporous polycythemia
+
+203
+00:15:55,850 --> 00:16:03,710
+الـ Causes stress cigarette smoker alcohol intake
+
+204
+00:16:03,710 --> 00:16:09,530
+ال dehydration و ال plasma loss او ال burn injury
+
+205
+00:16:09,530 --> 00:16:14,050
+وهذا الجدول يظهر لـ differential diagnosis of
+
+206
+00:16:14,050 --> 00:16:18,010
+borisathina which is summarized in this schedule
+
+207
+00:16:18,010 --> 00:16:22,090
+كما تشاهدون هذه القسم الأولاني هو عبارة عن
+
+208
+00:16:22,090 --> 00:16:27,390
+laboratory variableاللي بدنا نقارن ابو وهنا التلات
+
+209
+00:16:27,390 --> 00:16:33,550
+أنواع ال PPP البراندالز ال secondary فال
+
+210
+00:16:33,550 --> 00:16:45,330
+BCP is raised في كل التلاتة لكن ال RCM بزيد
+
+211
+00:16:45,330 --> 00:16:51,630
+في ال PPP normal في ال aberrant وفي زيادة في ال
+
+212
+00:16:51,630 --> 00:16:56,290
+secondary polysethemaالارترو بولتين الارترو بولتين
+
+213
+00:16:56,290 --> 00:16:58,290
+الارترو بولتين الارترو بولتين الارترو بولتين
+
+214
+00:16:58,290 --> 00:17:01,830
+الارترو بولتين الارترو بولتين الارترو بولتين
+
+215
+00:17:01,830 --> 00:17:08,910
+الارترو بولتين الارترو
+
+216
+00:17:08,910 --> 00:17:10,450
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+217
+00:17:10,450 --> 00:17:11,130
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+218
+00:17:11,130 --> 00:17:12,930
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+219
+00:17:12,930 --> 00:17:15,510
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+220
+00:17:15,510 --> 00:17:18,410
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+221
+00:17:18,410 --> 00:17:22,990
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+222
+00:17:22,990 --> 00:17:30,320
+بولتبتعمل بدل ال body organs atrial
+
+223
+00:17:30,320 --> 00:17:33,400
+spleen
+
+224
+00:17:33,400 --> 00:17:37,480
+is enlarged في ال BBB normal في التنتين atrial PO2
+
+225
+00:17:37,480 --> 00:17:41,660
+normal في ال BBB normal في ال apparent or decrease
+
+226
+00:17:41,660 --> 00:17:46,500
+or normal في ال secondary 13 بقل في ال BBB
+
+227
+00:17:49,070 --> 00:17:59,510
+السيراب بي تولف ايضا فرق بي بي بي بي بي
+
+228
+00:17:59,510 --> 00:18:04,090
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+229
+00:18:04,090 --> 00:18:05,070
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+230
+00:18:05,070 --> 00:18:07,880
+بي بي بي بي بي بي بي بي بي بي بي بي بي بيالمشكلة
+
+231
+00:18:07,880 --> 00:18:16,820
+الموجودة في بي بي بي بي
+
+232
+00:18:16,820 --> 00:18:20,060
+بي
+
+233
+00:18:20,060 --> 00:18:20,820
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+234
+00:18:20,820 --> 00:18:20,880
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+235
+00:18:20,880 --> 00:18:20,960
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+236
+00:18:20,960 --> 00:18:23,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+237
+00:18:23,620 --> 00:18:29,320
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+238
+00:18:29,320 --> 00:18:36,930
+بي بمشكلة عامة يشكي المريض اللي عنده بوليسا أثيمة
+
+239
+00:18:36,930 --> 00:18:44,730
+و بلو هدك و blurred vision زغولة ثم diziness دوخة
+
+240
+00:18:44,730 --> 00:18:49,390
+ثم mental impairment عدم تركيز ثم feeling of
+
+241
+00:18:49,390 --> 00:18:54,390
+congestion on the head أيضا
+
+242
+00:18:54,390 --> 00:18:59,270
+بيعاني من splenomegaly لأنه فيه اكتر مدلة لهموبيسس
+
+243
+00:19:00,730 --> 00:19:03,490
+والـ hyperviscosity و الـ impairment of blood flow
+
+244
+00:19:03,490 --> 00:19:07,890
+بتساهم في زيادة ال incidence of arterial and
+
+245
+00:19:07,890 --> 00:19:13,110
+venous thrombosis عشان هيك في إلها علاج لازم تاخده
+
+246
+00:19:13,110 --> 00:19:18,230
+يعني أقل من الـ platelet اللي هو ال baby aspirin
+
+247
+00:19:18,230 --> 00:19:23,370
+ثم الـ platelet dysfunction هو تندنسي to bruise، a
+
+248
+00:19:23,370 --> 00:19:28,170
+bleeding تندنسي موجودة لكن مش شغالة ثم الـ severe
+
+249
+00:19:28,170 --> 00:19:35,670
+itching في حكة فظيعةparticularly بعد warm bath
+
+250
+00:19:35,670 --> 00:19:42,530
+وهذا نتج عن الهستامين
+
+251
+00:19:42,530 --> 00:19:48,030
+الذي تم إطلاقه من البيزوفيل يوجد إتشينغ خصوصا بعد
+
+252
+00:19:48,030 --> 00:19:53,090
+حمام ساخن لأن هناك زيادة في إفراز الهستامين من
+
+253
+00:19:53,090 --> 00:19:57,670
+البيزوفيل عبارة عن ال finding نجد كريسي مجلو بين
+
+254
+00:19:57,670 --> 00:20:02,780
+pcv و rbcزيادة في الـ granulocyte نيوتروفيل
+
+255
+00:20:02,780 --> 00:20:05,920
+morphology and function are increased platelet
+
+256
+00:20:05,920 --> 00:20:11,120
+increases لكن خمسين في المائية by bizarre shape و
+
+257
+00:20:11,120 --> 00:20:15,980
+.. و .. خمس .. platelet increase by about fifty
+
+258
+00:20:15,980 --> 00:20:22,580
+percent و الاشكال الغير طبيعية زي ال bizarre shape
+
+259
+00:20:22,580 --> 00:20:25,760
+platelet morphology and dysfunction هذا شيء common
+
+260
+00:20:25,760 --> 00:20:31,100
+common with hypercellularبريدوناس او over
+
+261
+00:20:31,100 --> 00:20:36,320
+granulocytes و الارترود هي paraplegia is less
+
+262
+00:20:36,320 --> 00:20:41,080
+common cytogenetic abnormality اللي موجودة يعني
+
+263
+00:20:41,080 --> 00:20:48,860
+موجودة في 15% من حالات ال .. بالحالات presentation
+
+264
+00:20:51,550 --> 00:20:54,030
+هذه التحقيقات البرنامجية Normal, neutrophil,
+
+265
+00:20:54,090 --> 00:20:58,790
+alkaline, urate, plasma urate, circulate,
+
+266
+00:20:59,910 --> 00:21:07,530
+erythroid, precursor, low serum erythropoietin
+
+267
+00:21:07,530 --> 00:21:10,670
+clinical
+
+268
+00:21:10,670 --> 00:21:13,950
+feature majority of patient بيعانوا من الاذين
+
+269
+00:21:13,950 --> 00:21:18,910
+thrombosis بما فيها ال portal ansplenic vein
+
+270
+00:21:20,710 --> 00:21:27,930
+هي DVT و DV نتhrombosis وهيبرتنشن هيديك و poor
+
+271
+00:21:27,930 --> 00:21:33,630
+vision and dizziness skin
+
+272
+00:21:33,630 --> 00:21:38,730
+complication بما فيها البرورايتس و الارتروميليلجيا
+
+273
+00:21:38,730 --> 00:21:45,550
+could be و ال homeridge GIT due to platelet defect
+
+274
+00:21:45,550 --> 00:21:48,750
+وهي
+
+275
+00:21:48,750 --> 00:21:50,090
+الارتروميليلجيا
+
+276
+00:21:51,960 --> 00:21:57,640
+الحمار الليبي وشكل طبعا فيه بتوسبين وميجا دي زي ما
+
+277
+00:21:57,640 --> 00:22:01,360
+انتوا شايفين liver عالي و السبنين عالي
+
+278
+00:22:01,360 --> 00:22:08,920
+الارتروباليريا have increased skin temperature and
+
+279
+00:22:08,920 --> 00:22:16,580
+burning sensation or redness25% من الحالات تجلب
+
+280
+00:22:16,580 --> 00:22:20,880
+لـChronic Myelofibrosis وطول الحالات تجلب لـ Acute
+
+281
+00:22:20,880 --> 00:22:28,360
+Lymphoid Lymphoplastic Leukemia وغالباً التعامل
+
+282
+00:22:28,360 --> 00:22:37,300
+بالكيموترابي اللي مرتبط بالتغيير لـ ANLL المعاملة
+
+283
+00:22:37,300 --> 00:22:42,770
+التعاملية الرئيسية هي تقليد التعامل الروبوتيكيعشان
+
+284
+00:22:42,770 --> 00:22:44,970
+تقلل من الـ Thrombotic Complication بيعملوا
+
+285
+00:22:44,970 --> 00:22:51,390
+Debulking بيشيلوا RBCs by removal of RBCs and
+
+286
+00:22:51,390 --> 00:22:56,230
+platelets وهذه العملية بتام by Aphoresis or by
+
+287
+00:22:56,230 --> 00:23:01,650
+repeated clonal proliferation median survival time
+
+288
+00:23:01,650 --> 00:23:06,630
+بيواصل 15 سنة وفي additional treatment may not be
+
+289
+00:23:06,630 --> 00:23:11,970
+needed because it's controversial زي الكيموثيرابي
+
+290
+00:23:15,860 --> 00:23:17,260
+زي ثرابو
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..39b088eb03bc5a9f59a2fb456e5550edfcf5d91c
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/RhrEB18kYBg_raw.srt
@@ -0,0 +1,1184 @@
+1
+00:00:01,670 --> 00:00:06,830
+بسم الله الرحمن الرحيم نلتقي
+
+2
+00:00:06,830 --> 00:00:11,530
+اليوم أيضا في معادرة بعنوان the non-leukemic
+
+3
+00:00:11,530 --> 00:00:20,070
+malignant disorders by definition non-leukemic
+
+4
+00:00:20,070 --> 00:00:25,520
+malignant disordersبشكل أساسي بإنهم مجموعات مورفوس
+
+5
+00:00:25,520 --> 00:00:30,080
+و لينال ديس أورداز بيتميزوا بـ uncontrolled clonal
+
+6
+00:00:30,080 --> 00:00:33,400
+proliferation of bone marrow دلوقت سنة أي خلية من
+
+7
+00:00:33,400 --> 00:00:39,020
+خلايا البون مارور بلد سيلولار اللي موجودة في البون
+
+8
+00:00:39,020 --> 00:00:41,560
+مارور بسللها abnormal clonal proliferation
+
+9
+00:00:41,560 --> 00:00:46,200
+وبالتالي بزيد عددها زيادة مهولة Classification
+
+10
+00:00:46,200 --> 00:00:50,350
+قسموها إلى أنواعينمالكنا نتمييله proliferative
+
+11
+00:00:50,350 --> 00:00:54,130
+disorders وهدى بتشمل primary proliferative
+
+12
+00:00:54,130 --> 00:00:58,590
+polycythemia و primary thrombocythemia و
+
+13
+00:00:58,590 --> 00:01:01,070
+myelofibrosis و احنا هنتطرق اليهم ان شاء الله
+
+14
+00:01:01,070 --> 00:01:04,510
+بالتفصيل ثم المالكنا نتلمفه proliferative
+
+15
+00:01:04,510 --> 00:01:11,330
+disorders و اختارنالكم multiple myeloma and
+
+16
+00:01:11,330 --> 00:01:15,130
+related plasma cell disorders ثم Hodgkin disease و
+
+17
+00:01:15,130 --> 00:01:16,190
+non Hodgkin lymphoma
+
+18
+00:01:18,750 --> 00:01:22,890
+ونبدأ بالـ Myeloproliferative non-leukemic
+
+19
+00:01:22,890 --> 00:01:27,770
+myeloproliferative disorders واتفقنا على أن هذا
+
+20
+00:01:27,770 --> 00:01:32,390
+عبارة عن hemipietic stem cell disorders انه كلونل
+
+21
+00:01:32,390 --> 00:01:36,810
+وتميز بوجود granulocytic و erythrocytic و
+
+22
+00:01:36,810 --> 00:01:45,110
+megakaryocytic increase تلاتة بصير لهم abnormal
+
+23
+00:01:45,110 --> 00:01:49,100
+clonal proliferationموجود هو انه فيه inter
+
+24
+00:01:49,100 --> 00:01:54,960
+relation between this increase and their diseases
+
+25
+00:01:54,960 --> 00:02:00,540
+فعلى سبيل المثال RBCs بيسموها polycythemia
+
+26
+00:02:00,540 --> 00:02:04,740
+platelet بيسموها central thrombocythemia ثم ال
+
+27
+00:02:04,740 --> 00:02:11,980
+myelofibrosis هو عبارة عن fibrosis نتيجة ال mega
+
+28
+00:02:11,980 --> 00:02:16,350
+karyocytic abnormalclonal proliferation of
+
+29
+00:02:16,350 --> 00:02:22,390
+megakaryocytic proliferation
+
+30
+00:02:22,390 --> 00:02:27,970
+طبعا هى زى ما انتوا شايفين هى عبارة عن ال استيبواز
+
+31
+00:02:27,970 --> 00:02:32,290
+ال progression of to fibrosis to marrow failure or
+
+32
+00:02:32,290 --> 00:02:35,590
+acute blast phase زى ما انتوا شايفين هى ال bone
+
+33
+00:02:35,590 --> 00:02:41,750
+marrow stem cell اكتسبت meditation ال abnormal و
+
+34
+00:02:41,750 --> 00:02:47,550
+required abnormalityفالتأثر طبعا لجرانيولوستيك وال
+
+35
+00:02:47,550 --> 00:02:50,810
+RBCs والميجاكاريوستيك لأننا بنحكي على
+
+36
+00:02:50,810 --> 00:02:55,650
+myeloproliferase جرانيولوستيك لما صار هكلونا ال
+
+37
+00:02:55,650 --> 00:03:01,710
+proliferation أدتنا chronic myeloid leukemia و ال
+
+38
+00:03:01,710 --> 00:03:08,860
+RBCs precursor أدى polycythemia أو Robraviraوالـ
+
+39
+00:03:08,860 --> 00:03:12,940
+Megakaryocytes is the essential thrombocythemia
+
+40
+00:03:12,940 --> 00:03:18,640
+which can transform to reactive fibrosis وبتكون
+
+41
+00:03:18,640 --> 00:03:24,400
+الاش ميلوفيبروسيس ولاحظوا العلاقة ما بين هذه
+
+42
+00:03:24,400 --> 00:03:29,310
+الأمراض وما بين ال acute myeloid leukemia فجالواان
+
+43
+00:03:29,310 --> 00:03:33,030
+ال chronic myeloid leukemia 70% منها بيجلب ل acute
+
+44
+00:03:33,030 --> 00:03:37,610
+myeloid leukemia polycythemia 10% منها بيجلب ل
+
+45
+00:03:37,610 --> 00:03:41,190
+acute myeloid leukemia central thrombocythemia
+
+46
+00:03:41,190 --> 00:03:47,890
+sorry polycythemia أيضا ممكن تتحول ل myelofibrosis
+
+47
+00:03:47,890 --> 00:03:53,370
+30% منها و ال myelofibrosis ممكن 10% منه يصير
+
+48
+00:03:53,370 --> 00:04:00,060
+acute myeloid leukemia ففي انترrelation between
+
+49
+00:04:00,060 --> 00:04:07,020
+these disorders نبدأ بأول هذه الانواع ال primary
+
+50
+00:04:07,020 --> 00:04:11,810
+proliferate polycythemiaالتي تسمى Malignant
+
+51
+00:04:11,810 --> 00:04:15,710
+disorders وفيهم بيوتكس تمثال And it's
+
+52
+00:04:15,710 --> 00:04:18,550
+characterized by absolute erythrocytosis يبقى
+
+53
+00:04:18,550 --> 00:04:23,390
+بماذا يتميز؟ يتميز by absolute erythrocytosis
+
+54
+00:04:23,390 --> 00:04:27,390
+وطبعا لأن الأم واحدة فبصير في مدلة ال increase
+
+55
+00:04:27,390 --> 00:04:34,070
+لجرانيو و ال count و ال platelet ممكن تيجي للإنسان
+
+56
+00:04:34,070 --> 00:04:42,500
+في أي عمرالخطوة المسلحة هي عمر الشباب في بيبول عمر
+
+57
+00:04:42,500 --> 00:04:48,440
+الشباب في بيبول هو حوالي 55 سنة الملابس يتأثرون
+
+58
+00:04:48,440 --> 00:04:51,620
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+59
+00:04:51,620 --> 00:04:54,820
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+60
+00:04:54,820 --> 00:04:55,060
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+61
+00:04:55,060 --> 00:04:55,360
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+62
+00:04:55,360 --> 00:04:56,140
+بشكل اكتر من الشباب بشكل اكتر من الشباب بشكل اكتر
+
+63
+00:04:56,140 --> 00:04:56,960
+من الشباب بشكل اكتر من الشباب بشكل اكتر من الشباب
+
+64
+00:04:56,960 --> 00:05:07,190
+بشكل اكتر من الشبالتي تتعامل بشكل اتانومس في الـ
+
+65
+00:05:07,190 --> 00:05:10,510
+abnormal decline الـ
+
+66
+00:05:10,510 --> 00:05:15,910
+disease phases قالوا فيه تلاتة phases غالبا
+
+67
+00:05:15,910 --> 00:05:21,030
+proliferative phase ثم spent او post polycyathemic
+
+68
+00:05:21,030 --> 00:05:26,090
+phase وقلنا rarely transformed into acute leukemia
+
+69
+00:05:26,090 --> 00:05:27,150
+فهذا phase تالت
+
+70
+00:05:30,380 --> 00:05:34,420
+recognition of polycythemia قالوا ال recognition
+
+71
+00:05:34,420 --> 00:05:37,940
+by measuring ال back cell volume او ال hematocrit
+
+72
+00:05:37,940 --> 00:05:41,540
+وجدوا ان ال male المفروض يكون اكتر من واحد و خمسين
+
+73
+00:05:41,540 --> 00:05:51,140
+و ال female اكتر من تمانية و ربعين و التغير
+
+74
+00:05:51,140 --> 00:05:56,060
+في ال PCB ممكن يكون له سبب اخر وهو ال reduction in
+
+75
+00:05:56,060 --> 00:06:04,340
+plasma اوTrue increase in RBCs number يبقى هذه
+
+76
+00:06:04,340 --> 00:06:11,680
+أسباب ال polycythemia Classification قسموها لنوعين
+
+77
+00:06:11,680 --> 00:06:16,640
+أساسيين جاله ال absolute أو بيسمى true و ال true
+
+78
+00:06:16,640 --> 00:06:21,370
+بتشمل primary proliferate polycythemiaاللي احنا
+
+79
+00:06:21,370 --> 00:06:24,830
+تاول حكينا عنها ثم secondary polycythemia
+
+80
+00:06:24,830 --> 00:06:29,730
+وidiopathic erythrocytosis for unknown reason
+
+81
+00:06:29,730 --> 00:06:34,150
+بتلاقي ال RBC's عالية نوع التاني من ال
+
+82
+00:06:34,150 --> 00:06:37,770
+polycythemia هو ال apparent or relative وهذه
+
+83
+00:06:37,770 --> 00:06:45,870
+نتيجات البلازما volume or RBC's mass changes نرجع
+
+84
+00:06:45,870 --> 00:06:49,690
+لل
+
+85
+00:06:53,560 --> 00:06:58,280
+absolute لأسباب الـabsolute polycythemia قالوا
+
+86
+00:06:58,280 --> 00:07:02,000
+الـmalignant transformation بيخلّي ال hemopoietic
+
+87
+00:07:02,000 --> 00:07:06,060
+stem cell to be free from hormonal control
+
+88
+00:07:06,060 --> 00:07:09,080
+وبالتالي
+
+89
+00:07:09,080 --> 00:07:13,640
+لا تتأثر بتغير الهرمون اللي هو الارتروبيتينهرمون
+
+90
+00:07:13,640 --> 00:07:16,680
+عشان هيك الارتروبيتينهرمون is decreased في هذه
+
+91
+00:07:16,680 --> 00:07:21,920
+الحالات hypoxic effect has no effect
+
+92
+00:07:26,580 --> 00:07:31,220
+فيزيولوجيا ممكن ان يكون هناك استميلات غير مناسبة
+
+93
+00:07:31,220 --> 00:07:31,700
+أو استميلات غير مناسبة أو استميلات غير مناسبة او
+
+94
+00:07:31,700 --> 00:07:33,000
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+95
+00:07:33,000 --> 00:07:34,620
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+96
+00:07:34,620 --> 00:07:35,400
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+97
+00:07:35,400 --> 00:07:37,940
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+98
+00:07:37,940 --> 00:07:39,420
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+99
+00:07:39,420 --> 00:07:40,900
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+100
+00:07:40,900 --> 00:07:44,740
+استميلات غير مناسبة او استميلات غير مناسبة او
+
+101
+00:07:44,740 --> 00:07:52,400
+استميلات غير مناسباللي abnormal ال primary
+
+102
+00:07:52,400 --> 00:07:56,480
+proliferative polycythemia and this is a malignant
+
+103
+00:07:56,480 --> 00:08:05,900
+disorder لكن الفهم أنواع ال polycythemia بالكامل
+
+104
+00:08:05,900 --> 00:08:10,760
+هو عبارة عن ضرورةلأن الـ recognition of primary
+
+105
+00:08:10,760 --> 00:08:15,400
+progressive prosethemia is based on exclusion
+
+106
+00:08:29,780 --> 00:08:38,120
+بينلي ال classification of polycythemia اي
+
+107
+00:08:38,120 --> 00:08:43,940
+polycythemia vera او ال PCV تكون عالية اسمها ال
+
+108
+00:08:43,940 --> 00:08:48,920
+absolute او بيسموه true و ان هذا بيحتوي على نوعين
+
+109
+00:08:48,920 --> 00:08:53,200
+نوع الأولاني بيسموه primaryو الارتروبيوتين فيه
+
+110
+00:08:53,200 --> 00:08:59,220
+بيكون decreased و النوع التاني هو ال secondary
+
+111
+00:08:59,220 --> 00:09:03,460
+والارتروبيوتين فيه بيكون عالي بالنسبة لل secondary
+
+112
+00:09:03,460 --> 00:09:06,660
+اللي بيبقى الارتروبيوتين فيه عالي زيادة
+
+113
+00:09:06,660 --> 00:09:09,340
+الارتروبيوتين ممكن تكون due to appropriate cause
+
+114
+00:09:09,340 --> 00:09:12,700
+or inappropriate cause فال appropriate cause زي ال
+
+115
+00:09:12,700 --> 00:09:18,510
+attitude هذا واضح طبيعيزي الـ Cardiopulmonary برضه
+
+116
+00:09:18,510 --> 00:09:22,790
+و ده طبيعي زي ال smoking بيقدّي الى زيادة
+
+117
+00:09:22,790 --> 00:09:26,150
+الارتروبيوتين و لما appropriate وجود cancer او
+
+118
+00:09:26,150 --> 00:09:31,810
+tumor او even cyst بعيدة عن الاسوأن كان في الكدن
+
+119
+00:09:31,810 --> 00:09:38,330
+ولا زي renal ولا extra renal tumor هذا بيحفظ على
+
+120
+00:09:38,330 --> 00:09:43,110
+إنتاج الارتروبيوتينما التاني من الـ polycythemia
+
+121
+00:09:43,110 --> 00:09:45,630
+هو الـ apparent اللي يكون في الـ red cell mass
+
+122
+00:09:45,630 --> 00:09:49,450
+could be normal لكن due to hydration or stress or
+
+123
+00:09:49,450 --> 00:09:54,630
+smoking بيبدأ يحصل فيه زيادة نسبية لل RBCs mass
+
+124
+00:09:54,630 --> 00:10:03,010
+بالنسبة لل plasma secondary polycythemia usually
+
+125
+00:10:03,010 --> 00:10:10,260
+due to known causes وقالوا في منهانوعين كمبنساتوري
+
+126
+00:10:10,260 --> 00:10:14,440
+انكريز في الارتروبيوتين او appropriate release of
+
+127
+00:10:14,440 --> 00:10:17,640
+arteropoietin زي في حالة ال high attitude
+
+128
+00:10:17,640 --> 00:10:21,280
+pulmonary disease heart disease زي ال cyanotic
+
+129
+00:10:21,280 --> 00:10:24,460
+heart disease abnormal hemoglobin high affinity
+
+130
+00:10:24,460 --> 00:10:28,060
+hemoglobin heavy cigarette smokers كل هذه عبارة عن
+
+131
+00:10:28,060 --> 00:10:31,620
+أسباب و حالات مرضية بيصير فيها appropriate or
+
+132
+00:10:31,620 --> 00:10:36,190
+compensatory increase in arteropoietinالنوع التاني
+
+133
+00:10:36,190 --> 00:10:39,310
+اللي هو appropriate erythropoietin production يوم
+
+134
+00:10:39,310 --> 00:10:43,530
+زي ما قلنا يكون فيه tumor سواء كان رينال ولا
+
+135
+00:10:43,530 --> 00:10:50,490
+فيبروميونة موجودة في extra-renal او hydronephrosis
+
+136
+00:10:50,490 --> 00:10:54,730
+في الرينال و liver carcinoma extra-renal و هكذا
+
+137
+00:10:54,730 --> 00:11:00,970
+دول كلهم عبارة عن cancers بيؤدوا بيحفظوا على تصنيع
+
+138
+00:11:00,970 --> 00:11:06,050
+ال erythropoietin بس دون الحاجة لهوبالتالي يزيد
+
+139
+00:11:06,050 --> 00:11:11,530
+الارثروبياتين نسبياً Caused physiological
+
+140
+00:11:11,530 --> 00:11:14,410
+appropriate release of arithopoietin
+
+141
+00:11:14,410 --> 00:11:17,170
+وPhysiologically inappropriate release of
+
+142
+00:11:17,170 --> 00:11:21,970
+arithopoietin الفيزيولوجيكي اترابيت ايه ريليز
+
+143
+00:11:21,970 --> 00:11:27,570
+الارثروبياتين يعني اسبابها كالعادية السبب الأولاني
+
+144
+00:11:27,570 --> 00:11:30,170
+ان يكون الارثروبياتين مستمرين في اتماسك اكسجين
+
+145
+00:11:30,170 --> 00:11:33,790
+تنشئ انت جاعد في مكان مافيش فيه اكسجينزي ما يحصل
+
+146
+00:11:33,790 --> 00:11:39,490
+في الـ high altitude السبب التاني هو in adequate
+
+147
+00:11:39,490 --> 00:11:44,770
+uptake of atmospheric oxygen فيه أكسجين بس انت
+
+148
+00:11:44,770 --> 00:11:48,690
+مابتاخده بالكميات المقلوبة زي ال chronic
+
+149
+00:11:48,690 --> 00:11:52,170
+bronchitis ايه الفيزياما بلموناري فيبروسيز
+
+150
+00:11:52,170 --> 00:11:56,750
+بلموناري اديما هذا سبب شائع فكرة كتير يبقى الأولان
+
+151
+00:11:56,750 --> 00:11:59,410
+ان انت قاعد في جوء مافيش فيه أكسجين تاني فيه
+
+152
+00:11:59,410 --> 00:12:05,420
+أكسجينلكن ما بتعرف تاخده او تاخده inadequately سبب
+
+153
+00:12:05,420 --> 00:12:11,480
+تالت انه في اكسوجين انت جاعد في جو فيه اكسوجين و
+
+154
+00:12:11,480 --> 00:12:16,920
+بتاخد الاكسوجين appropriately او adequately لكن
+
+155
+00:12:16,920 --> 00:12:19,660
+بيصير فيه defect في ال transport of absorbed
+
+156
+00:12:19,660 --> 00:12:25,080
+oxygen from the lung وهذا ممكن يصير في variety of
+
+157
+00:12:25,080 --> 00:12:28,400
+inherited or acquired defect of hemoglobin
+
+158
+00:12:28,400 --> 00:12:33,460
+functionالمشكلة المتابلية التي تقلل إدارة
+
+159
+00:12:33,460 --> 00:12:36,940
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+160
+00:12:36,940 --> 00:12:39,140
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+161
+00:12:39,140 --> 00:12:39,560
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+162
+00:12:39,560 --> 00:12:40,340
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+163
+00:12:40,340 --> 00:12:42,480
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+164
+00:12:42,480 --> 00:12:44,720
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+165
+00:12:44,720 --> 00:12:47,360
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتاج
+
+166
+00:12:47,360 --> 00:12:51,140
+إلى إدارة الهيموجلوبين تحتاج إلى إدارة
+
+167
+00:12:51,140 --> 00:12:57,700
+الهيموجلوبين تحتاج إلى إدارة الهيموجلوبين تحتالـ
+
+168
+00:12:57,700 --> 00:12:59,800
+Physiologically Inappropriate Release of
+
+169
+00:12:59,800 --> 00:13:04,380
+erythropoietin فيه variety of disorders associated
+
+170
+00:13:04,380 --> 00:13:06,640
+with inappropriate release of erythropoietin
+
+171
+00:13:06,640 --> 00:13:11,960
+occurs as a rare complication of renal disorders
+
+172
+00:13:11,960 --> 00:13:16,380
+زي polycystic kidney, chronic lumbar nephritis,
+
+173
+00:13:16,600 --> 00:13:24,310
+hydronephrosis, renal tumorAn extrarenal tumor زي
+
+174
+00:13:24,310 --> 00:13:27,910
+الهيباطومة والبرونكيل الكارسينومة كلها عبارة عن
+
+175
+00:13:27,910 --> 00:13:34,430
+حالات مرضية بتخلق الواحد المريضي to release the
+
+176
+00:13:34,430 --> 00:13:38,370
+erythropoietin inappropriately هاي ال secondary
+
+177
+00:13:38,370 --> 00:13:41,290
+prostatemia برضه حالات مرضية زي ال arterial blood
+
+178
+00:13:41,290 --> 00:13:48,690
+gasعشان تشخص ال secondary polycythemia بدك تعمل
+
+179
+00:13:48,690 --> 00:13:54,410
+الفعوصات القاتية نمرة واحد arterial blood gas نمرة
+
+180
+00:13:54,410 --> 00:13:58,550
+اتنين hemoglobin electrophoresis نمرة تلاتة oxygen
+
+181
+00:13:58,550 --> 00:14:03,050
+dissociation care نمرة اربعة erythropoietin level
+
+182
+00:14:03,050 --> 00:14:08,990
+خمسة ultrasound abdomen and chest x-ray بعدين
+
+183
+00:14:08,990 --> 00:14:15,340
+total insulin volume تشوفوا ثابت ولا لأby labeling
+
+184
+00:14:15,340 --> 00:14:20,820
+the RBCs by Chromium 51 وهي Total Plasma Volume
+
+185
+00:14:20,820 --> 00:14:27,540
+ايضا by labeling by one Iodine 125 مرتبط
+
+186
+00:14:27,540 --> 00:14:31,360
+بالالبومين
+
+187
+00:14:31,360 --> 00:14:36,320
+الـ
+
+188
+00:14:36,320 --> 00:14:40,480
+Appropriate Procythemia rather than defined as
+
+189
+00:14:40,480 --> 00:14:40,720
+those
+
+190
+00:15:01,850 --> 00:15:06,930
+أو باستخدام مجموعات الرسمية الروحانية الروحانية
+
+191
+00:15:06,930 --> 00:15:10,910
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+192
+00:15:10,910 --> 00:15:10,990
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+193
+00:15:10,990 --> 00:15:10,990
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+194
+00:15:10,990 --> 00:15:10,990
+الروحانية الروحانية الروحانية الروحانية الروحانية
+
+195
+00:15:10,990 --> 00:15:12,490
+الروحانية الروحانية الروحانية الروحانية الروحانيةو
+
+196
+00:15:12,490 --> 00:15:16,730
+ال بي بي towards the lower limit of normality يعني
+
+197
+00:15:16,730 --> 00:15:20,830
+هدا كيصل على ال lower limit اللي ما تقريت و هدا
+
+198
+00:15:20,830 --> 00:15:25,830
+كيصل لبلاسما على ال upper limit of ash of بلاسما
+
+199
+00:15:25,830 --> 00:15:29,210
+اجراء البروسيثيميا is by far the most common
+
+200
+00:15:29,210 --> 00:15:36,650
+finding where ال PCB is only minimally increased و
+
+201
+00:15:36,650 --> 00:15:41,730
+بشكل حقبيكون أو بيصل لغاية خمسين فمية of such
+
+202
+00:15:41,730 --> 00:15:45,550
+cases alternative names of this condition include
+
+203
+00:15:45,550 --> 00:15:47,990
+relative polycythemia, solid polycythemia,
+
+204
+00:15:48,110 --> 00:15:53,250
+stressed polycythemia and sporous polycythemia
+
+205
+00:15:55,850 --> 00:16:03,710
+الـ Causes stress cigarette smoker alcohol intake
+
+206
+00:16:03,710 --> 00:16:09,530
+ال dehydration و ال plasma loss او ال burn injury
+
+207
+00:16:09,530 --> 00:16:14,050
+وهذا الجدول يظهر لـ differential diagnosis of
+
+208
+00:16:14,050 --> 00:16:18,010
+borisathina which is summarized in this schedule
+
+209
+00:16:18,010 --> 00:16:22,090
+كما تشاهدون هذه القسم الأولاني هو عبارة عن
+
+210
+00:16:22,090 --> 00:16:27,390
+laboratory variableاللي بدنا نقارن ابو وهنا التلات
+
+211
+00:16:27,390 --> 00:16:33,550
+أنواع ال PPP البراندالز ال secondary فال
+
+212
+00:16:33,550 --> 00:16:45,330
+BCP is raised في كل التلاتة لكن ال RCM بزيد
+
+213
+00:16:45,330 --> 00:16:51,630
+في ال PPP normal في ال aberrant وفي زيادة في ال
+
+214
+00:16:51,630 --> 00:16:56,290
+secondary polysethemaالارترو بولتين الارترو بولتين
+
+215
+00:16:56,290 --> 00:16:58,290
+الارترو بولتين الارترو بولتين الارترو بولتين
+
+216
+00:16:58,290 --> 00:17:01,830
+الارترو بولتين الارترو بولتين الارترو بولتين
+
+217
+00:17:01,830 --> 00:17:08,910
+الارترو بولتين الارترو
+
+218
+00:17:08,910 --> 00:17:10,450
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+219
+00:17:10,450 --> 00:17:11,130
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+220
+00:17:11,130 --> 00:17:12,930
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+221
+00:17:12,930 --> 00:17:15,510
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+222
+00:17:15,510 --> 00:17:18,410
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+223
+00:17:18,410 --> 00:17:22,990
+بولتين الارترو بولتين الارترو بولتين الارترو
+
+224
+00:17:22,990 --> 00:17:30,320
+بولتبتعمل بدل ال body organs atrial
+
+225
+00:17:30,320 --> 00:17:33,400
+spleen
+
+226
+00:17:33,400 --> 00:17:37,480
+is enlarged في ال BBB normal في التنتين atrial PO2
+
+227
+00:17:37,480 --> 00:17:41,660
+normal في ال BBB normal في ال apparent or decrease
+
+228
+00:17:41,660 --> 00:17:46,500
+or normal في ال secondary 13 بقل في ال BBB
+
+229
+00:17:49,070 --> 00:17:59,510
+السيراب بي تولف ايضا فرق بي بي بي بي بي
+
+230
+00:17:59,510 --> 00:18:04,090
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+231
+00:18:04,090 --> 00:18:05,070
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+232
+00:18:05,070 --> 00:18:05,070
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+233
+00:18:05,070 --> 00:18:05,070
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+234
+00:18:05,070 --> 00:18:05,070
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+235
+00:18:05,070 --> 00:18:07,880
+بي بي بي بي بي بي بي بي بي بي بي بي بي بيالمشكلة
+
+236
+00:18:07,880 --> 00:18:16,820
+الموجودة في بي بي بي بي
+
+237
+00:18:16,820 --> 00:18:20,060
+بي
+
+238
+00:18:20,060 --> 00:18:20,820
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+239
+00:18:20,820 --> 00:18:20,880
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+240
+00:18:20,880 --> 00:18:20,960
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+241
+00:18:20,960 --> 00:18:23,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+242
+00:18:23,620 --> 00:18:23,620
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+243
+00:18:23,620 --> 00:18:29,320
+بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي
+
+244
+00:18:29,320 --> 00:18:36,930
+بي بمشكلة عامة يشكي المريض اللي عنده بوليسا أثيمة
+
+245
+00:18:36,930 --> 00:18:44,730
+و بلو هدك و blurred vision زغولة ثم diziness دوخة
+
+246
+00:18:44,730 --> 00:18:49,390
+ثم mental impairment عدم تركيز ثم feeling of
+
+247
+00:18:49,390 --> 00:18:54,390
+congestion on the head أيضا
+
+248
+00:18:54,390 --> 00:18:59,270
+بيعاني من splenomegaly لأنه فيه اكتر مدلة لهموبيسس
+
+249
+00:19:00,730 --> 00:19:03,490
+والـ hyperviscosity و الـ impairment of blood flow
+
+250
+00:19:03,490 --> 00:19:07,890
+بتساهم في زيادة ال incidence of arterial and
+
+251
+00:19:07,890 --> 00:19:13,110
+venous thrombosis عشان هيك في إلها علاج لازم تاخده
+
+252
+00:19:13,110 --> 00:19:18,230
+يعني أقل من الـ platelet اللي هو ال baby aspirin
+
+253
+00:19:18,230 --> 00:19:23,370
+ثم الـ platelet dysfunction هو تندنسي to bruise، a
+
+254
+00:19:23,370 --> 00:19:28,170
+bleeding تندنسي موجودة لكن مش شغالة ثم الـ severe
+
+255
+00:19:28,170 --> 00:19:35,670
+itching في حكة فظيعةparticularly بعد warm bath
+
+256
+00:19:35,670 --> 00:19:42,530
+وهذا نتج عن الهستامين
+
+257
+00:19:42,530 --> 00:19:48,030
+الذي تم إطلاقه من البيزوفيل يوجد إتشينغ خصوصا بعد
+
+258
+00:19:48,030 --> 00:19:53,090
+حمام ساخن لأن هناك زيادة في إفراز الهستامين من
+
+259
+00:19:53,090 --> 00:19:57,670
+البيزوفيل عبارة عن ال finding نجد كريسي مجلو بين
+
+260
+00:19:57,670 --> 00:20:02,780
+pcv و rbcزيادة في الـ granulocyte نيوتروفيل
+
+261
+00:20:02,780 --> 00:20:05,920
+morphology and function are increased platelet
+
+262
+00:20:05,920 --> 00:20:11,120
+increases لكن خمسين في المائية by bizarre shape و
+
+263
+00:20:11,120 --> 00:20:15,980
+.. و .. خمس .. platelet increase by about fifty
+
+264
+00:20:15,980 --> 00:20:22,580
+percent و الاشكال الغير طبيعية زي ال bizarre shape
+
+265
+00:20:22,580 --> 00:20:25,760
+platelet morphology and dysfunction هذا شيء common
+
+266
+00:20:25,760 --> 00:20:31,100
+common with hypercellularبريدوناس او over
+
+267
+00:20:31,100 --> 00:20:36,320
+granulocytes و الارترود هي paraplegia is less
+
+268
+00:20:36,320 --> 00:20:41,080
+common cytogenetic abnormality اللي موجودة يعني
+
+269
+00:20:41,080 --> 00:20:48,860
+موجودة في 15% من حالات ال .. بالحالات presentation
+
+270
+00:20:51,550 --> 00:20:54,030
+هذه التحقيقات البرنامجية Normal, neutrophil,
+
+271
+00:20:54,090 --> 00:20:58,790
+alkaline, urate, plasma urate, circulate,
+
+272
+00:20:59,910 --> 00:21:07,530
+erythroid, precursor, low serum erythropoietin
+
+273
+00:21:07,530 --> 00:21:10,670
+clinical
+
+274
+00:21:10,670 --> 00:21:13,950
+feature majority of patient بيعانوا من الاذين
+
+275
+00:21:13,950 --> 00:21:18,910
+thrombosis بما فيها ال portal ansplenic vein
+
+276
+00:21:20,710 --> 00:21:27,930
+هي DVT و DV نتhrombosis وهيبرتنشن هيديك و poor
+
+277
+00:21:27,930 --> 00:21:33,630
+vision and dizziness skin
+
+278
+00:21:33,630 --> 00:21:38,730
+complication بما فيها البرورايتس و الارتروميليلجيا
+
+279
+00:21:38,730 --> 00:21:45,550
+could be و ال homeridge GIT due to platelet defect
+
+280
+00:21:45,550 --> 00:21:48,750
+وهي
+
+281
+00:21:48,750 --> 00:21:50,090
+الارتروميليلجيا
+
+282
+00:21:51,960 --> 00:21:57,640
+الحمار الليبي وشكل طبعا فيه بتوسبين وميجا دي زي ما
+
+283
+00:21:57,640 --> 00:22:01,360
+انتوا شايفين liver عالي و السبنين عالي
+
+284
+00:22:01,360 --> 00:22:08,920
+الارتروباليريا have increased skin temperature and
+
+285
+00:22:08,920 --> 00:22:16,580
+burning sensation or redness25% من الحالات تجلب
+
+286
+00:22:16,580 --> 00:22:20,880
+لـChronic Myelofibrosis وطول الحالات تجلب لـ Acute
+
+287
+00:22:20,880 --> 00:22:28,360
+Lymphoid Lymphoplastic Leukemia وغالباً التعامل
+
+288
+00:22:28,360 --> 00:22:37,300
+بالكيموترابي اللي مرتبط بالتغيير لـ ANLL المعاملة
+
+289
+00:22:37,300 --> 00:22:42,770
+التعاملية الرئيسية هي تقليد التعامل الروبوتيكيعشان
+
+290
+00:22:42,770 --> 00:22:44,970
+تقلل من الـ Thrombotic Complication بيعملوا
+
+291
+00:22:44,970 --> 00:22:51,390
+Debulking بيشيلوا RBCs by removal of RBCs and
+
+292
+00:22:51,390 --> 00:22:56,230
+platelets وهذه العملية بتام by Aphoresis or by
+
+293
+00:22:56,230 --> 00:23:01,650
+repeated clonal proliferation median survival time
+
+294
+00:23:01,650 --> 00:23:06,630
+بيواصل 15 سنة وفي additional treatment may not be
+
+295
+00:23:06,630 --> 00:23:11,970
+needed because it's controversial زي الكيموثيرابي
+
+296
+00:23:15,860 --> 00:23:17,260
+زي ثرابو
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..07629c5208269cb5bc7d3896ff323573c17bcc7c
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4.srt
@@ -0,0 +1,709 @@
+1
+00:00:03,100 --> 00:00:06,680
+بسم الله الرحمن الرحيم استكمالا لمحاضرة non-Hodgkin
+
+2
+00:00:06,680 --> 00:00:09,860
+lymphochemical malignant أو lymph proliferative
+
+3
+00:00:09,860 --> 00:00:16,240
+disorders هناخد مثال آخر وهو ال Hodgkin disease 
+
+4
+00:00:16,240 --> 00:00:18,600
+Hodgkin disease هو عبارة عن neoplastic disorder
+
+5
+00:00:18,600 --> 00:00:23,920
+بيكون فيه خلية بيتميز بوجود خلية بيسموها Reed
+
+6
+00:00:23,920 --> 00:00:30,220
+Sternberg cell و ال Reed Sternberg cell هذه غريبة
+
+7
+00:00:30,220 --> 00:00:35,290
+بتنشأ من ال lymph nodes و it's restricted only to
+
+8
+00:00:35,290 --> 00:00:41,430
+the lymph nodes it's not يعني it can spread to the
+
+9
+00:00:41,430 --> 00:00:46,310
+contiguous group of lymph node إنما تطلع برا ال
+
+10
+00:00:46,310 --> 00:00:50,790
+lymph node يعني it's very rare و غالبا بما أننا
+
+11
+00:00:50,790 --> 00:00:53,410
+بنحكي على lymph node involvement يبقى بنحكي على
+
+12
+00:00:53,410 --> 00:00:57,890
+اللي هو defective immunity لأن ساحات المعارك في
+
+13
+00:00:57,890 --> 00:01:00,190
+الجسم هي عبارة عن ال lymph nodes
+
+14
+00:01:07,510 --> 00:01:12,550
+الانسيدنس الانسيدنس من حالتين إلى أربع حالات لكل مئة ألف
+
+15
+00:01:12,550 --> 00:01:16,830
+من ال population في السنة وال by modal age
+
+16
+00:01:16,830 --> 00:01:19,870
+distribution بيصيب الناس في السن خمسة عشر إلى خمسة و
+
+17
+00:01:19,870 --> 00:01:24,190
+ثلاثين سنة و بيصيب الناس اللي فوق الخمسين سنة ال
+
+18
+00:01:24,190 --> 00:01:27,230
+male كالعادة أكثر من ال female 1.7 to
+
+19
+00:01:27,230 --> 00:01:35,630
+1 وال pathophysiology أنه أهم حاجة إن المريض
+
+20
+00:01:35,630 --> 00:01:40,230
+غالبا يعاني من painless at presentation يعني
+
+21
+00:01:40,230 --> 00:01:44,610
+ويعاني من painlessness يعني asymmetrical
+
+22
+00:01:44,610 --> 00:01:50,610
+enlargement of lymph nodes يعني مافيش ألم في ال
+
+23
+00:01:50,610 --> 00:01:54,850
+lymph nodes enlargement which lymph node قالوا إما
+
+24
+00:01:54,850 --> 00:01:59,450
+cervical أو subclavicular lymph nodes لكن هذا لا
+
+25
+00:01:59,450 --> 00:02:04,270
+يستثني ال axillary و ال inguinal أو femoral ماشي
+
+26
+00:02:04,270 --> 00:02:07,130
+بيجي المريض بيكون عنده lymph node enlargement
+
+27
+00:02:07,130 --> 00:02:16,170
+بتحسسها فيه ألم؟ لا فاش ألم وبالتالي بيكون this
+
+28
+00:02:16,170 --> 00:02:22,350
+is at presentation يعني عند التشخيص اللي ال lymph
+
+29
+00:02:22,350 --> 00:02:24,930
+nodes ممكن يكون مصحوب ب generalized itching
+
+30
+00:02:28,030 --> 00:02:30,710
+بالمقارنة مع الـ Non-Hodgkin lymphoma عادة الـ
+
+31
+00:02:30,710 --> 00:02:33,110
+Hodgkin disease بيكون Restricted at presentation
+
+32
+00:02:33,110 --> 00:02:38,650
+في حين الـ Non-Hodgkin lymphoma تكون Systemic أو
+
+33
+00:02:38,650 --> 00:02:44,950
+Disseminated at presentation ال presence of Alexia
+
+34
+00:02:44,950 --> 00:02:47,590
+و Night sweating يعني غالبا associated with
+
+35
+00:02:47,590 --> 00:02:53,130
+advanced disease Clinical presentation يعني بيكون
+
+36
+00:02:53,130 --> 00:02:56,470
+non-tender lymph node enlargement سواء كان في
+
+37
+00:02:56,470 --> 00:03:02,570
+العنق أو الميدياستينوم أو الإدينوباثي أقدم من إكثرها
+
+38
+00:03:02,570 --> 00:03:06,890
+في ديزيز سيستميك سيمتوم زي الفير نايت سويتنج
+
+39
+00:03:06,890 --> 00:03:12,290
+unexplained weight loss كمان وآخر سيمتوم زي الفتق
+
+40
+00:03:12,290 --> 00:03:16,230
+و weakness pruritis pruritis الحكة كاف و chest pain
+
+41
+00:03:16,230 --> 00:03:21,750
+shortness of breath وفينا كافا سندروم و ال abdominal
+
+42
+00:03:21,750 --> 00:03:27,790
+pain power disturbances, ascites و بومبين كل هذا
+
+43
+00:03:27,790 --> 00:03:35,230
+عبارة عن symptoms لمرضى recognition غيرها
+
+44
+00:03:35,230 --> 00:03:40,370
+هذا المرض الدم بيكون خالي تماما ال peripheral
+
+45
+00:03:40,370 --> 00:03:43,410
+blood ما بنشوف فيه أي حاجة أو حتى ال bone marrow
+
+46
+00:03:43,410 --> 00:03:47,790
+is not involved لأنها هي كداء disease of
+
+47
+00:03:47,790 --> 00:03:53,090
+pathologist مش disease of hematologist لكن بما أن
+
+48
+00:03:53,090 --> 00:04:00,290
+الـ bone marrow يعني is ال .. ال hematologically
+
+49
+00:04:00,290 --> 00:04:05,570
+affected يعني تترقنا إلى هذا المرض بوجود بعض 
+
+50
+00:04:05,570 --> 00:04:08,290
+passive changes such as myelotrombocytosis
+
+51
+00:04:08,290 --> 00:04:14,810
+neutrophilia relative eosinophilia is present و جميع
+
+52
+00:04:14,810 --> 00:04:18,430
+ال anemia وال thrombocytopenia و leukocytoblastosis
+
+53
+00:04:18,430 --> 00:04:23,180
+كلهم بوجودهم بيعني أن المرض in its advanced
+
+54
+00:04:23,180 --> 00:04:31,620
+stage لكن اللي بيميز is not involvement is only
+
+55
+00:04:31,620 --> 00:04:37,900
+involved in advanced stage لكنه it's uncommon at
+
+56
+00:04:37,900 --> 00:04:43,960
+presentation الأهم حاجة أن ناخد عينة من ال lymph
+
+57
+00:04:43,960 --> 00:04:50,180
+node biopsy و نشوف و ندور عليها اللي هو presence
+
+58
+00:04:50,180 --> 00:04:55,260
+of infiltrate لخلايا كثيرة يتخلل هذه الخلايا اللي
+
+59
+00:04:55,260 --> 00:05:01,120
+هو ال RS cell و ضروري جدا وجود ال RS cell للتشخيص
+
+60
+00:05:02,360 --> 00:05:06,520
+وإن كان ليس محدودا لأنه بنشوفها في أمراض أخرى زي
+
+61
+00:05:06,520 --> 00:05:08,240
+الـ Non-Hodgkin lymphoma أو الـ Chronic
+
+62
+00:05:08,240 --> 00:05:12,160
+lymphocytic leukemia غير الـ Hodgkin disease الـ
+
+63
+00:05:12,160 --> 00:05:16,120
+RS cell is typically هي عبارة عن large cell فيها
+
+64
+00:05:16,120 --> 00:05:22,440
+two or more large oval nuclei كل
+
+65
+00:05:22,440 --> 00:05:27,480
+واحدة منهم فيها nucleolus و ال nucleolus is
+
+66
+00:05:27,480 --> 00:05:32,700
+separated from ال nuclear membrane by a clear zone
+
+67
+00:05:32,700 --> 00:05:37,020
+يعني في فرق ما بين الـ nucleoli و ال nuclear
+
+68
+00:05:37,020 --> 00:05:40,900
+membrane classification
+
+69
+00:05:40,900 --> 00:05:44,380
+عملوا classification according to the pattern of
+
+70
+00:05:44,380 --> 00:05:52,700
+infiltration لل lymph node biopsy فقسموها إلى أربع
+
+71
+00:05:52,700 --> 00:05:56,180
+حالات مرضية والواحد ال lymphocyte predominant و
+
+72
+00:05:56,180 --> 00:06:01,160
+من الاسم بيكون في infiltrate مليان بال lymphocytes
+
+73
+00:06:03,080 --> 00:06:07,420
+النوع الثاني Nodular Sclerosis بيكون فيه اللي هو
+
+74
+00:06:07,420 --> 00:06:13,660
+تجمع حلقى لل infiltrate
+
+75
+00:06:13,660 --> 00:06:18,240
+و برضه بيتخلله ال RS Cell لكن ال RS Cell بتتميز
+
+76
+00:06:18,240 --> 00:06:23,680
+بشكل مختلف وهو ال lacunar cell بيسموها lacunar
+
+77
+00:06:23,680 --> 00:06:27,340
+cell اللي بيكون فيها ال cytoplasm is contracted
+
+78
+00:06:27,340 --> 00:06:35,930
+مضغوط شوية وكأنه كأنها عبارة عن Artifact Sclerosis
+
+79
+00:06:35,930 --> 00:06:41,210
+أيضا موجود نتيجة كلاجة برضه قسموه إلى أقسام
+
+80
+00:06:41,210 --> 00:06:45,890
+مختلفة هذا بيصيب أربعين في المائة أو بيشكل أربعين
+
+81
+00:06:45,890 --> 00:06:50,870
+في المائة من الحالات وغالبا associated with thymic
+
+82
+00:06:50,870 --> 00:06:56,110
+origin ويوجد Prognosis النوع الثالث اللي هو Mixed
+
+83
+00:06:56,110 --> 00:06:58,390
+Cellularity من الاسم يعني فيه أكثر من نوع من
+
+84
+00:06:58,390 --> 00:06:58,970
+الخلايا
+
+85
+00:07:02,620 --> 00:07:07,380
+الـ RS Cell بتكون أيضا Scattered Within These
+
+86
+00:07:07,380 --> 00:07:11,500
+Cells Lymphocyte Depleted من الاسم مافيش
+
+87
+00:07:11,500 --> 00:07:18,000
+Lymphocytes بتكون خلايا كبيرة الـ RS ومصحوبة
+
+88
+00:07:18,000 --> 00:07:21,940
+ب Histiocytes لكن الـ Lymphocyte is scant  scant يعني
+
+89
+00:07:21,940 --> 00:07:28,540
+قليل ال Immunophenotyping يعني بيتكلم عن خلايا
+
+90
+00:07:30,220 --> 00:07:36,900
+الـ RS أو الـ Reed Sternberg cell على سطح CD25، IL-2
+
+91
+00:07:36,900 --> 00:07:44,220
+receptor، CD15 و CD30 ويقسموا الأنواع إلى B و T
+
+92
+00:07:44,220 --> 00:07:48,240
+lymphocytes فغالبا الـ NS اللي هو nodular sclerosis
+
+93
+00:07:48,240 --> 00:07:51,320
+و الـ mixed cellularity هم عبارة عن B lymphoid
+
+94
+00:07:51,320 --> 00:07:57,620
+malignancy بينما ال lymphocyte predominant هي عبارة
+
+95
+00:07:57,620 --> 00:08:02,790
+عن T lymphoid markers عملوا staging للمرض قالوا فيه
+
+96
+00:08:02,790 --> 00:08:05,910
+أربع stages  رقم واحد اللي هي involvement of
+
+97
+00:08:05,910 --> 00:08:09,390
+single lymph nodes رقم اثنين فيه اثنين أو أكثر من
+
+98
+00:08:09,390 --> 00:08:11,530
+lymph nodes are involved لكن at the same
+
+99
+00:08:11,530 --> 00:08:14,590
+anatomical
+
+100
+00:08:14,590 --> 00:08:18,770
+site رقم ثلاثة في involvement of lymph node
+
+101
+00:08:18,770 --> 00:08:23,200
+regions on both sides of the body ورقم أربعة
+
+102
+00:08:23,200 --> 00:08:25,940
+بيصير فيه diffuse or disseminated involvement
+
+103
+00:08:25,940 --> 00:08:33,480
+لواحد أو أكثر من واحد له extra lymphatic organ ب
+
+104
+00:08:33,480 --> 00:08:36,520
+.. with or without associated lymph node
+
+105
+00:08:36,520 --> 00:08:43,080
+involvement treatment حسب ال stage ال early stage
+
+106
+00:08:43,080 --> 00:08:47,420
+بدها localized radiotherapy بينما ال advanced
+
+107
+00:08:47,420 --> 00:08:52,940
+stage بدها chemotherapy ال prognosis طبعا وجدوا
+
+108
+00:08:52,940 --> 00:08:58,520
+أنه 80% من حالات اللي بتجينا في stage number one و
+
+109
+00:08:58,520 --> 00:09:01,580
+أكثر من 50% من stage number four of Hodgkin
+
+110
+00:09:01,580 --> 00:09:05,400
+disease ممكن يعيش عشر سنوات أو أكثر at the
+
+111
+00:09:05,400 --> 00:09:10,760
+presentation طبعا هذا بيعتبر نوع من أنواع الشفاء
+
+112
+00:09:10,760 --> 00:09:15,300
+وبهيك بنكون غطينا ال Hodgkin disease لما أن
+
+113
+00:09:15,300 --> 00:09:23,580
+Hodgkin lymphoma هذا عالم آخر عادة بي .. يعني في
+
+114
+00:09:23,580 --> 00:09:30,740
+منه كتب في هذا ال hemopoietic malignancy و هذه
+
+115
+00:09:30,740 --> 00:09:35,900
+تقسيمة لكل ال malignant hematological
+
+116
+00:09:35,900 --> 00:09:40,100
+malignancy هي ال myeloproliferative و إيش بتشمل
+
+117
+00:09:40,100 --> 00:09:43,900
+بكيميا و إيش في أنواع و ال malignant lymphoma و احنا
+
+118
+00:09:43,900 --> 00:09:47,320
+قلنا الـ Hodgkin و الـ Non-Hodgkin اللي بتنقسم إلى
+
+119
+00:09:47,320 --> 00:09:50,060
+Burkitt's Lymphoma و Cutaneous T Cell Leukemia
+
+120
+00:09:50,060 --> 00:09:56,560
+للمفومة وهكذا Non-Hodgkin Lymphoma by definition
+
+121
+00:09:56,560 --> 00:09:59,920
+هي بلعنة heterogeneous group of B cell
+
+122
+00:09:59,920 --> 00:10:03,700
+Malignancy اللي هي that are diverse in cellular
+
+123
+00:10:03,700 --> 00:10:08,060
+origin and morphology انسايات الجيناتيك و انسايات
+
+124
+00:10:08,060 --> 00:10:08,560
+الانصائيات الانصائيات الانصائيات الانصائيات
+
+125
+00:10:08,560 --> 00:10:10,620
+الانصائيات الانصائيات الانصائيات الانصائيات
+
+126
+00:10:10,620 --> 00:10:11,920
+الانصائيات الانصائيات الانصائيات الانصائيات
+
+127
+00:10:11,920 --> 00:10:19,200
+الانصائية الانصائية الانصائية الانصائية الانصائية
+
+128
+00:10:19,200 --> 00:10:21,860
+الانصائية الانصائية الانصائية الانصائية الانصائية
+
+129
+00:10:21,860 --> 00:10:23,400
+الانصائية الانصائية الانصائية الانصائية الانصائية
+
+130
+00:10:23,400 --> 00:10:24,260
+الانصائية الانصائية الانصائية الانصائية الانصائية
+
+131
+00:10:24,260 --> 00:10:27,800
+الانصائية الانصائية الانصائية الانصائية الانصائية
+
+132
+00:10:27,800 --> 00:10:32,660
+الانصائية الانصائية
+
+133
+00:10:37,010 --> 00:10:42,950
+التحديات الأخيرة اقتنعت بإعادة إبتكار البارباريس 
+
+134
+00:10:42,950 --> 00:10:46,890
+المرتبط بالإنقاذ من الـ Non-Hodgkin lymphoma
+
+135
+00:10:46,890 --> 00:10:54,410
+.البيانات الوبائية أيضا أظهرت تجارب صغيرة من
+
+136
+00:10:54,410 --> 00:10:58,600
+الـ Non-Hodgkin lymphoma بين الناس المزارعين و ال
+
+137
+00:10:58,600 --> 00:11:07,320
+rubber industry people و their significance of
+
+138
+00:11:07,320 --> 00:11:13,880
+their of this observation still in doubt  ساعة
+
+139
+00:11:13,880 --> 00:11:15,800
+genetic abnormality وجدوا فيه كروموسوم ال
+
+140
+00:11:15,800 --> 00:11:18,860
+abnormality فيه أكثر من كروموسوم زي اثنين وثلاثة و
+
+141
+00:11:18,860 --> 00:11:22,100
+سبعة عشر واثنا عشر و أربعة عشر وثمانية عشر وال
+
+142
+00:11:22,100 --> 00:11:24,840
+pathophysiology قالوا يحصل فيه lymphomas with
+
+143
+00:11:24,840 --> 00:11:29,480
+follicular pattern overgrowth بتكون less aggressive
+
+144
+00:11:29,480 --> 00:11:34,060
+than diffuse pattern نمرأتين small lymphocytic
+
+145
+00:11:34,060 --> 00:11:39,060
+lymphoma أقل شراسة من الـ large cell lymphoma
+
+146
+00:11:39,060 --> 00:11:45,800
+نمرأتلاتة بالمقارنة بالأكيد لوكيميا بعد الـ high
+
+147
+00:11:45,800 --> 00:11:48,980
+grade lymphoma are more amenable to treatment
+
+148
+00:11:48,980 --> 00:11:55,180
+قابلة للعلاج على عكس الـ chronic types of leukemia
+
+149
+00:11:57,020 --> 00:12:00,120
+أيضا in contrast to Hodgkin disease الـ non
+
+150
+00:12:00,120 --> 00:12:03,460
+Hodgkin lymphoma is disseminated at presentation
+
+151
+00:12:03,460 --> 00:12:10,700
+هناك بتكون localized هذه تقسيمة 85% من اللمفومة
+
+152
+00:12:10,700 --> 00:12:15,480
+هيوران Hodgkin lymphoma وطبعا
+
+153
+00:12:15,480 --> 00:12:18,880
+أنا مش كتير معنى أني أركزلكوا على هذا المرض الصحيح
+
+154
+00:12:18,880 --> 00:12:22,980
+لأن هو disease of pathologist أكثر منه disease of
+
+155
+00:12:22,980 --> 00:12:27,220
+a hematologist وهذه تقسيمات الـ non-Hodgkin
+
+156
+00:12:27,220 --> 00:12:31,240
+lymphoma أربعة stages نفس الحكاية according to the
+
+157
+00:12:31,240 --> 00:12:35,940
+age while staging أيوة هذا طبعا زي إنكم بتعرفوا
+
+158
+00:12:35,940 --> 00:12:39,340
+أنه قسم الإنسان إلى two sides اللي فوق الـ upper و
+
+159
+00:12:39,340 --> 00:12:43,460
+الـ lower هي involvement of one of lymph node in
+
+160
+00:12:43,460 --> 00:12:47,360
+one side أكثر من lymph nodes لكن on the same side
+
+161
+00:12:47,360 --> 00:12:52,180
+هنا lymph node involvement in both sides ثم في
+
+162
+00:12:52,180 --> 00:12:59,230
+extra nodal organ involved in bone marrow في الآخر و
+
+163
+00:12:59,230 --> 00:13:06,230
+liver are involved classification according to the
+
+164
+00:13:06,230 --> 00:13:13,150
+infiltration of cells in biopsy جاله في تلت أنواع
+
+165
+00:13:13,150 --> 00:13:15,750
+low grade lymphoma intermediate grade lymphoma and
+
+166
+00:13:15,750 --> 00:13:20,210
+high grade lymphoma و treatment الـ lymphoma اللي
+
+167
+00:13:20,210 --> 00:13:23,910
+with follicular pattern اللي هما less aggressive
+
+168
+00:13:23,910 --> 00:13:27,050
+than those with diffuse pattern وبيحتاجوا إلى less
+
+169
+00:13:27,050 --> 00:13:30,650
+treatment small lymphocytic lymphoma أيضا less
+
+170
+00:13:30,650 --> 00:13:39,570
+aggressive than large و .. هذه شريحة إحنا حكيناها 
+
+171
+00:13:39,570 --> 00:13:44,470
+قبل هيك طبعا بالمقارنة بالـ acute leukemia بعض
+
+172
+00:13:44,470 --> 00:13:47,190
+الحالات من الـ high grade lymphoma عارقة منها
+
+173
+00:13:47,190 --> 00:13:53,020
+بولوتو treatment يعني قابلة للعلاج بينما بالمقارنة
+
+174
+00:13:53,020 --> 00:13:55,620
+مع الـ Hodgkin disease مع الـ Hodgkin lymphoma
+
+175
+00:13:55,620 --> 00:14:01,760
+usually is disseminated at presentation وبهيك بكون
+
+176
+00:14:01,760 --> 00:14:11,820
+انتهيت المحاضرة وانتهيت أيضا المهد ده وشكرا 
+
+177
+00:14:11,820 --> 00:14:19,020
+للاستماعكم معنا أرجو أن تكونوا قد استمتعتم معنا
+
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..b638143d0de57f12aef9cebd8d5e9e142e623539
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/SmoduOgvFz4_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 3158, "start": 3.1, "end": 31.58, "text": "بسم الله الرحمن الرحيم استكمالا لمحاضرة non non-lochemical malignant او lymph proliferative disorders هناخد مثال اخر وهو ال Hodgkin disease ال Hodgkin disease هو عبارة عن neo plastic disorder بيكون فيه خلية بيتميز بولود خلية بيسموها Red Steinberg cell و ال Red Steinberg cell هذه غريبا بتنشأ من ال lymph nodes", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 44713, 24793, 6027, 995, 5296, 2304, 5016, 46958, 25720, 2107, 2107, 12, 752, 34114, 2806, 36818, 1975, 2407, 31070, 24398, 9361, 1166, 20261, 8032, 1863, 47283, 3215, 50113, 6027, 1975, 34740, 37037, 2407, 2423, 45151, 70, 5843, 4752, 2423, 45151, 70, 5843, 4752, 31439, 6225, 3555, 9640, 3660, 18871, 41977, 5900, 13399, 4724, 1829, 30544, 8978, 3224, 16490, 1211, 10632, 4724, 36081, 2304, 1829, 11622, 4724, 12610, 23328, 16490, 1211, 10632, 4724, 1829, 38251, 2407, 11296, 4477, 29453, 6873, 2815, 4032, 2423, 4477, 29453, 6873, 2815, 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diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/TEa8D_iPsLc_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/TEa8D_iPsLc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..beac6555b00d64a8f89e8750257f5133a1f5d45a
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@@ -0,0 +1 @@
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new file mode 100644
index 0000000000000000000000000000000000000000..3bf0a2447689ad888c8268102b6ef38b48d2816d
--- /dev/null
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جينا تطلعنا هلاقيها منتشرة في معظم الحياة العالم المناطق الثلاثينية طبعا اشهرها ده هي منطقة اللي هي ال Mediterranean area هنا وهي منطقة اللي هو السعودية و بعدين تنزل على اللي هو غرب أوروبا و هكذا", "tokens": [1211, 13063, 15042, 1975, 2407, 6055, 4587, 16572, 3555, 995, 45164, 10874, 1829, 8315, 6055, 9566, 1211, 3615, 8315, 8032, 15040, 38436, 11296, 9154, 2655, 8592, 25720, 8978, 20449, 19913, 2304, 21542, 25528, 3660, 18863, 45340, 2423, 27842, 41193, 4587, 6024, 104, 1211, 5718, 104, 9957, 10632, 23032, 3555, 3615, 995, 1975, 8592, 3224, 2288, 11296, 11778, 3224, 39896, 9154, 9566, 28671, 13672, 1829, 39896, 2423, 27280, 1859, 34105, 37037, 1829, 9154, 9566, 28671, 13672, 1829, 31439, 21136, 3615, 23328, 10632, 4032, 39182, 9957, 6055, 1863, 11622, 1211, 15844, 13672, 1829, 31439, 32771, 25513, 5551, 13063, 37746, 995, 4032, 8032, 4117, 15730], "avg_logprob": -0.1870448968364197, "compression_ratio": 1.7799043062200957, "no_speech_prob": 4.827976226806641e-06, "words": [{"start": 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مختلف غالبا beta ناتجة عن post mutation مش ناتجة عن growth dilation", "tokens": [41185, 25124, 3555, 4117, 3660, 16712, 7649, 10632, 8608, 20292, 2304, 6156, 3224, 2407, 3639, 2032, 1229, 70, 563, 42963, 33753, 2304, 6027, 23758, 24976, 9640, 3555, 27884, 4724, 1829, 38251, 2407, 11296, 3166, 8636, 45841, 13496, 3166, 420, 15435, 384, 950, 304, 301, 4032, 1829, 17082, 1829, 3555, 6055, 1211, 9307, 3660, 23758, 31439, 8717, 2655, 9566, 1211, 3615, 15844, 8961, 9984, 8961, 1804, 3834, 3639, 2032, 1229, 70, 563, 4724, 1829, 38251, 2407, 11296, 5551, 15042, 20666, 1863, 35457, 3660, 24976, 9861, 12, 392, 304, 8604, 29958, 10874, 6027, 3224, 9673, 2407, 11242, 45367, 3714, 46456, 46538, 32771, 6027, 3555, 995, 9861, 8717, 9307, 7435, 3660, 18871, 2183, 27960, 37893, 8717, 9307, 7435, 3660, 18871, 4599, 11504, 399], "avg_logprob": -0.30113634984355325, "compression_ratio": 1.595505617977528, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 431.09, "end": 431.27, "word": "في", 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791.45, "text": "as adult لو اتطلعنا عليه بيكون فيه no hematological abnormality بتاعة اللي كل الفحصات بتلاقيها طبيعية ماعدد DNA Analysis لما تفحص ال DNA Analysis بتلاقي فقط في ال umbilical core of newborn يعني إيش؟ يعني عند الولادة it may contain one percent of hemoglobin parts إيش ال hemoglobin parts؟ هو عبارة عن gamma four ليش؟ لأن أنا بحكي على Alpha", "tokens": [296, 5075, 45164, 1975, 2655, 9566, 1211, 3615, 8315, 47356, 4724, 1829, 30544, 8978, 3224, 572, 8636, 267, 4383, 47104, 1860, 39894, 995, 27884, 13672, 1829, 28242, 27188, 5016, 9381, 9307, 39894, 15040, 38436, 11296, 23032, 21292, 3615, 10632, 19446, 22488, 3215, 8272, 38172, 5296, 15042, 6055, 5172, 5016, 9381, 2423, 8272, 38172, 39894, 15040, 38436, 6156, 47432, 8978, 2423, 1105, 15384, 804, 4965, 295, 32928, 37495, 22653, 11933, 1829, 8592, 22807, 37495, 22653, 43242, 2423, 12610, 18513, 3660, 309, 815, 5304, 472, 3043, 295, 8636, 45841, 13496, 3166, 11933, 1829, 8592, 2423, 8636, 45841, 13496, 3166, 22807, 31439, 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0.736328125}, {"start": 786.71, "end": 786.81, "word": " ال", "probability": 0.21044921875}, {"start": 786.81, "end": 787.23, "word": " hemoglobin", "probability": 0.9261067708333334}, {"start": 787.23, "end": 788.05, "word": " parts؟", "probability": 0.86865234375}, {"start": 788.05, "end": 788.23, "word": " هو", "probability": 0.90625}, {"start": 788.23, "end": 788.47, "word": " عبارة", "probability": 0.969482421875}, {"start": 788.47, "end": 788.67, "word": " عن", "probability": 0.978515625}, {"start": 788.67, "end": 788.89, "word": " gamma", "probability": 0.422119140625}, {"start": 788.89, "end": 789.27, "word": " four", "probability": 0.5830078125}, {"start": 789.27, "end": 790.19, "word": " ليش؟", "probability": 0.775634765625}, {"start": 790.19, "end": 790.39, "word": " لأن", "probability": 0.7353515625}, {"start": 790.39, "end": 790.51, "word": " أنا", "probability": 0.83056640625}, {"start": 790.51, "end": 790.87, "word": " بحكي", "probability": 0.9835205078125}, {"start": 790.87, "end": 791.05, "word": " على", "probability": 0.9580078125}, {"start": 791.05, "end": 791.45, "word": " Alpha", "probability": 0.486572265625}], "temperature": 1.0}, {"id": 30, "seek": 81922, "start": 792.06, "end": 819.22, "text": "هل جيت Alpha مين بيجي معاها لما بتتولد لما بتتصنع بيجي معاها Gamma طب إذا جلت Alpha مين بده يزيد ال Gamma يبقى ال Gamma في هذه المرحلة بده يزيد على حساب Alpha فبدها تتجمع الجامعة الزيادة مع بعض وتكويننا New Hemoglobin Ismohemoglobin parts ويبرمزوله Gamma 4 وتنسوش", "tokens": [3224, 1211, 10874, 36081, 20588, 3714, 9957, 4724, 1829, 7435, 1829, 20449, 995, 11296, 5296, 15042, 39894, 2655, 12610, 3215, 5296, 15042, 39894, 2655, 9381, 1863, 3615, 4724, 1829, 7435, 1829, 20449, 995, 11296, 24723, 1696, 23032, 3555, 11933, 15730, 10874, 1211, 2655, 20588, 3714, 9957, 47525, 3224, 7251, 11622, 25708, 2423, 24723, 1696, 7251, 3555, 4587, 7578, 2423, 24723, 1696, 8978, 29538, 9673, 2288, 5016, 37977, 47525, 3224, 7251, 11622, 25708, 15844, 11331, 3794, 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"end": 807.08, "word": " حساب", "probability": 0.8483072916666666}, {"start": 807.08, "end": 807.64, "word": " Alpha", "probability": 0.9658203125}, {"start": 807.64, "end": 808.62, "word": " فبدها", "probability": 0.8154296875}, {"start": 808.62, "end": 809.3, "word": " تتجمع", "probability": 0.98037109375}, {"start": 809.3, "end": 809.94, "word": " الجامعة", "probability": 0.8401692708333334}, {"start": 809.94, "end": 810.76, "word": " الزيادة", "probability": 0.916796875}, {"start": 810.76, "end": 811.08, "word": " مع", "probability": 0.99267578125}, {"start": 811.08, "end": 811.56, "word": " بعض", "probability": 0.989013671875}, {"start": 811.56, "end": 812.76, "word": " وتكويننا", "probability": 0.550830078125}, {"start": 812.76, "end": 813.02, "word": " New", "probability": 0.59326171875}, {"start": 813.02, "end": 813.72, "word": " Hemoglobin", "probability": 0.919921875}, {"start": 813.72, "end": 814.72, "word": " Ismohemoglobin", "probability": 0.6917724609375}, {"start": 814.72, "end": 815.24, "word": " parts", "probability": 0.297119140625}, {"start": 815.24, "end": 816.84, "word": " ويبرمزوله", "probability": 0.8251604352678571}, {"start": 816.84, "end": 817.4, "word": " Gamma", "probability": 0.92431640625}, {"start": 817.4, "end": 817.82, "word": " 4", "probability": 0.30224609375}, {"start": 817.82, "end": 819.22, "word": " وتنسوش", "probability": 0.869140625}], "temperature": 1.0}, {"id": 31, "seek": 84910, "start": 819.72, "end": 849.1, "text": "this is abnormal hemoglobin لأنه احنا عرفنا ان normal hemoglobin هو الذي يحتوي على two dissimilar globin chain و هنفش dissimilarity كلهم زي بعض الاربعة globin chain are gamma such individual can only be defined with complete reliability of by DNA analysis يعني لازم تعمله DNA analysis عشان تقول انه", "tokens": [11176, 307, 32847, 8636, 45841, 13496, 5296, 33456, 3224, 1975, 5016, 8315, 6225, 28480, 8315, 16472, 2710, 8636, 45841, 13496, 31439, 43527, 7251, 33753, 45865, 15844, 732, 7802, 332, 2202, 1563, 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"end": 824.56, "word": " عرفنا", "probability": 0.8743489583333334}, {"start": 824.56, "end": 824.9, "word": " ان", "probability": 0.6591796875}, {"start": 824.9, "end": 825.32, "word": " normal", "probability": 0.58544921875}, {"start": 825.32, "end": 826.12, "word": " hemoglobin", "probability": 0.916015625}, {"start": 826.12, "end": 826.82, "word": " هو", "probability": 0.94482421875}, {"start": 826.82, "end": 827.16, "word": " الذي", "probability": 0.576171875}, {"start": 827.16, "end": 827.86, "word": " يحتوي", "probability": 0.9747721354166666}, {"start": 827.86, "end": 828.14, "word": " على", "probability": 0.89111328125}, {"start": 828.14, "end": 828.6, "word": " two", "probability": 0.67236328125}, {"start": 828.6, "end": 829.52, "word": " dissimilar", "probability": 0.9410807291666666}, {"start": 829.52, "end": 830.2, "word": " globin", "probability": 0.6846923828125}, {"start": 830.2, "end": 830.66, "word": " chain", "probability": 0.59912109375}, {"start": 830.66, "end": 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"word": " individual", "probability": 0.888671875}, {"start": 841.52, "end": 841.78, "word": " can", "probability": 0.94921875}, {"start": 841.78, "end": 842.1, "word": " only", "probability": 0.8662109375}, {"start": 842.1, "end": 842.28, "word": " be", "probability": 0.90576171875}, {"start": 842.28, "end": 842.72, "word": " defined", "probability": 0.84716796875}, {"start": 842.72, "end": 842.98, "word": " with", "probability": 0.9052734375}, {"start": 842.98, "end": 843.44, "word": " complete", "probability": 0.796875}, {"start": 843.44, "end": 844.76, "word": " reliability", "probability": 0.78076171875}, {"start": 844.76, "end": 845.08, "word": " of", "probability": 0.74853515625}, {"start": 845.08, "end": 845.28, "word": " by", "probability": 0.55322265625}, {"start": 845.28, "end": 845.56, "word": " DNA", "probability": 0.9814453125}, {"start": 845.56, "end": 846.1, "word": " analysis", "probability": 0.6806640625}, {"start": 846.1, "end": 846.36, "word": " يعني", "probability": 0.7315673828125}, {"start": 846.36, "end": 846.66, "word": " لازم", "probability": 0.9723307291666666}, {"start": 846.66, "end": 847.16, "word": " تعمله", "probability": 0.8810221354166666}, {"start": 847.16, "end": 847.58, "word": " DNA", "probability": 0.94921875}, {"start": 847.58, "end": 848.06, "word": " analysis", "probability": 0.5791015625}, {"start": 848.06, "end": 848.5, "word": " عشان", "probability": 0.97705078125}, {"start": 848.5, "end": 848.82, "word": " تقول", "probability": 0.99169921875}, {"start": 848.82, "end": 849.1, "word": " انه", "probability": 0.722412109375}], "temperature": 1.0}, {"id": 32, "seek": 87364, "start": 849.82, "end": 873.64, "text": "and we have one alpha-globin gene المرة التانية هو alpha-thalassemia trait وقلنا إن المريض في هذه الحالة بيكون عنده two alpha-globin gene are deleted", "tokens": [474, 321, 362, 472, 8961, 12, 7191, 996, 259, 12186, 9673, 25720, 16712, 7649, 10632, 31439, 8961, 12, 392, 304, 8604, 29958, 22538, 4032, 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"word": " ضروري", "probability": 0.8939208984375}, {"start": 896.73, "end": 897.25, "word": " نعرف", "probability": 0.823974609375}, {"start": 897.25, "end": 898.09, "word": " which", "probability": 0.931640625}, {"start": 898.09, "end": 898.29, "word": " is", "probability": 0.96533203125}, {"start": 898.29, "end": 898.63, "word": " which", "probability": 0.9775390625}, {"start": 898.63, "end": 898.93, "word": " يعني", "probability": 0.9384765625}, {"start": 898.93, "end": 899.19, "word": " مين", "probability": 0.888427734375}, {"start": 899.19, "end": 899.39, "word": " اللي", "probability": 0.905517578125}, {"start": 899.39, "end": 899.85, "word": " موجود", "probability": 0.9869791666666666}, {"start": 899.85, "end": 900.09, "word": " عند", "probability": 0.98974609375}, {"start": 900.09, "end": 900.33, "word": " هذا", "probability": 0.873046875}, {"start": 900.33, "end": 900.87, "word": " المريض", "probability": 0.92041015625}, {"start": 900.87, "end": 901.47, "word": " عشان", "probability": 0.9786783854166666}, {"start": 901.47, "end": 901.85, "word": " تعمل", "probability": 0.9586588541666666}, {"start": 901.85, "end": 902.15, "word": " family", "probability": 0.90087890625}, {"start": 902.15, "end": 902.65, "word": " pedigree", "probability": 0.6879069010416666}, {"start": 902.65, "end": 903.45, "word": " وتعطيه", "probability": 0.76376953125}, {"start": 903.45, "end": 903.81, "word": " genetic", "probability": 0.85107421875}, {"start": 903.81, "end": 904.35, "word": " counseling", "probability": 0.8203125}], "temperature": 1.0}, {"id": 34, "seek": 92524, "start": 905.7, "end": 925.24, "text": "طيب ايش ال laboratory finding في هذه الحالة؟ جالو ال affected individual عنده microesthetic hypochromic anemia with no significant symptom يصير فيه مغلوب اتش formation وهذا can be demonstrated by sobra vital stain في بعض خلايا ال RBCs", "tokens": [9566, 1829, 3555, 1975, 1829, 8592, 2423, 16523, 5006, 8978, 29538, 21542, 6027, 3660, 22807, 10874, 6027, 2407, 2423, 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1.0}, {"id": 48, "seek": 129521, "start": 1267.31, "end": 1295.21, "text": "بيتا ثلاثيميا النوع التاني من الثلاثيميا هو البيتا ثلاثيميا يعني أنا بحكي على بيتا mutated beta-globin-A ماشي وهذا قلنا زي ما اتفقنا نتيجة عن point of mutation وقلنا بالخلل في هذا ال globin بيفرز لي ثلاث حالات مرضية البيتا ثلاثيميا minor or trait", "tokens": [3555, 36081, 995, 38637, 1211, 5718, 104, 32640, 25528, 28239, 45367, 16712, 7649, 1829, 9154, 6024, 104, 1211, 5718, 104, 32640, 25528, 31439, 2423, 21292, 2655, 995, 38637, 1211, 5718, 104, 32640, 25528, 37495, 22653, 41850, 4724, 5016, 4117, 1829, 15844, 4724, 36081, 995, 5839, 770, 9861, 12, 70, 752, 13496, 12, 32, 3714, 33599, 1829, 37037, 15730, 12174, 1211, 8315, 30767, 1829, 19446, 1975, 2655, 5172, 4587, 8315, 8717, 31371, 7435, 3660, 18871, 935, 295, 27960, 4032, 4587, 1211, 8315, 20666, 9778, 1211, 1211, 8978, 23758, 2423, 16125, 259, 4724, 33911, 2288, 11622, 32239, 38637, 1211, 5718, 104, 11331, 6027, 9307, 3714, 43042, 10632, 2423, 21292, 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"word": " يعني", "probability": 0.86865234375}, {"start": 1271.57, "end": 1271.71, "word": " أنا", "probability": 0.64306640625}, {"start": 1271.71, "end": 1272.11, "word": " بحكي", "probability": 0.9459228515625}, {"start": 1272.11, "end": 1272.29, "word": " على", "probability": 0.9013671875}, {"start": 1272.29, "end": 1273.11, "word": " بيتا", "probability": 0.6508382161458334}, {"start": 1273.11, "end": 1274.47, "word": " mutated", "probability": 0.6405029296875}, {"start": 1274.47, "end": 1274.87, "word": " beta", "probability": 0.70263671875}, {"start": 1274.87, "end": 1275.39, "word": "-globin", "probability": 0.77001953125}, {"start": 1275.39, "end": 1275.79, "word": "-A", "probability": 0.38018798828125}, {"start": 1275.79, "end": 1278.03, "word": " ماشي", "probability": 0.771240234375}, {"start": 1278.03, "end": 1279.85, "word": " وهذا", "probability": 0.735107421875}, {"start": 1279.85, "end": 1280.13, "word": " قلنا", "probability": 0.6789143880208334}, {"start": 1280.13, "end": 1280.35, "word": " زي", "probability": 0.90283203125}, {"start": 1280.35, "end": 1280.45, "word": " ما", "probability": 0.96142578125}, {"start": 1280.45, "end": 1280.99, "word": " اتفقنا", "probability": 0.97978515625}, {"start": 1280.99, "end": 1281.35, "word": " نتيجة", "probability": 0.85064697265625}, {"start": 1281.35, "end": 1281.51, "word": " عن", "probability": 0.76513671875}, {"start": 1281.51, "end": 1281.71, "word": " point", "probability": 0.90966796875}, {"start": 1281.71, "end": 1281.91, "word": " of", "probability": 0.469482421875}, {"start": 1281.91, "end": 1282.45, "word": " mutation", "probability": 0.96533203125}, {"start": 1282.45, "end": 1284.75, "word": " وقلنا", "probability": 0.8338623046875}, {"start": 1284.75, "end": 1287.91, "word": " بالخلل", "probability": 0.78997802734375}, {"start": 1287.91, "end": 1288.09, "word": " في", "probability": 0.96044921875}, {"start": 1288.09, "end": 1288.33, "word": " هذا", "probability": 0.9404296875}, {"start": 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Beta نهو الثلاثيمية Hemoglobin F بيوصل لـ 98% لكن لو كان في Double Heterozygous Beta Thalassemia Beta Plus Thalassemia بيكون فينا شوية Beta بتتصنع وبالتالي ال Hemoglobin F بدي قل لأن Beta أخدت من حسة Gamma", "tokens": [3224, 2407, 4724, 2288, 3224, 1863, 20588, 24723, 1696, 16070, 39184, 20588, 24723, 1696, 31439, 4724, 2288, 3224, 1863, 18568, 45841, 13496, 479, 39896, 3224, 8978, 2423, 39184, 389, 13395, 1229, 70, 563, 10126, 295, 33286, 334, 304, 8604, 29958, 3714, 9307, 3660, 33286, 8717, 3224, 2407, 6024, 104, 1211, 5718, 104, 32640, 10632, 18568, 45841, 13496, 479, 4724, 1829, 2407, 36520, 5296, 39184, 20860, 4, 44381, 45164, 25961, 8978, 16633, 389, 2398, 78, 1229, 70, 563, 33286, 334, 304, 8604, 29958, 33286, 7721, 334, 304, 8604, 29958, 4724, 1829, 30544, 8978, 8315, 13412, 2407, 10632, 33286, 39894, 2655, 9381, 1863, 3615, 46599, 6027, 2655, 6027, 1829, 2423, 18568, 45841, 13496, 479, 4724, 16254, 12174, 1211, 5296, 33456, 33286, 5551, 9778, 3215, 2655, 9154, 11331, 3794, 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"probability": 0.803369140625}, {"start": 2358.56, "end": 2358.68, "word": " يا", "probability": 0.1533203125}, {"start": 2358.68, "end": 2358.94, "word": " سوري", "probability": 0.5902506510416666}, {"start": 2358.94, "end": 2359.42, "word": " بنعمل", "probability": 0.8145345052083334}, {"start": 2359.42, "end": 2359.52, "word": " ال", "probability": 0.9345703125}, {"start": 2359.52, "end": 2360.26, "word": " اكتروفوريسيس", "probability": 0.928271484375}, {"start": 2360.26, "end": 2360.38, "word": " و", "probability": 0.79248046875}, {"start": 2360.38, "end": 2360.54, "word": " او", "probability": 0.781982421875}, {"start": 2360.54, "end": 2361.5, "word": " الاخرين", "probability": 0.59783935546875}, {"start": 2361.5, "end": 2361.78, "word": " اذا", "probability": 0.86474609375}, {"start": 2361.78, "end": 2362.06, "word": " كان", "probability": 0.99169921875}, {"start": 2362.06, "end": 2362.6, "word": " الفيرلتين", "probability": 0.98974609375}, {"start": 2362.6, "end": 2362.96, "word": " اقل", "probability": 0.97314453125}, {"start": 2362.96, "end": 2363.2, "word": " من", "probability": 0.99658203125}, {"start": 2363.2, "end": 2364.86, "word": " خمستاشر", "probability": 0.9732421875}, {"start": 2364.86, "end": 2366.36, "word": " بنضي", "probability": 0.45361328125}, {"start": 2366.36, "end": 2366.84, "word": " ايرن", "probability": 0.9767252604166666}, {"start": 2366.84, "end": 2366.98, "word": " و", "probability": 0.693359375}, {"start": 2366.98, "end": 2367.34, "word": " بنعمل", "probability": 0.951171875}, {"start": 2367.34, "end": 2367.78, "word": " CBC", "probability": 0.62841796875}, {"start": 2367.78, "end": 2368.12, "word": " مرة", "probability": 0.742919921875}, {"start": 2368.12, "end": 2368.56, "word": " تانية", "probability": 0.9930013020833334}, {"start": 2368.56, "end": 2368.84, "word": " اذا", "probability": 0.92626953125}, {"start": 2368.84, "end": 2369.5, "word": " اتصلح", "probability": 0.94189453125}, {"start": 2369.5, "end": 2369.82, "word": " كان", "probability": 0.88330078125}, {"start": 2369.82, "end": 2370.14, "word": " بيها", "probability": 0.9588216145833334}, {"start": 2370.14, "end": 2370.82, "word": " ماتصلحش", "probability": 0.88349609375}, {"start": 2370.82, "end": 2371.28, "word": " بندور", "probability": 0.90966796875}, {"start": 2371.28, "end": 2371.48, "word": " على", "probability": 0.8203125}, {"start": 2371.48, "end": 2371.9, "word": " ايش", "probability": 0.8816731770833334}, {"start": 2371.9, "end": 2372.7, "word": " على", "probability": 0.5126953125}], "temperature": 1.0}, {"id": 89, "seek": 240046, "start": 2373.59, "end": 2400.47, "text": "اللي هو الـ hemoglobinopathy or تلسينية طبعا الفحص التاني اللي هو فب ال FEP اللي هو free erythroid protoporphine فاكرين ال protoporphine اللي احنا حكيناه في ال heme cyanophysis احنا قولنا انه ممكن يزيد في ال iron deficiency ده هو في ال iron", "tokens": [6027, 20292, 31439, 2423, 39184, 8636, 45841, 13496, 404, 9527, 420, 6055, 1211, 3794, 9957, 10632, 23032, 3555, 3615, 995, 27188, 5016, 9381, 16712, 7649, 1829, 13672, 1829, 31439, 6156, 3555, 2423, 479, 8929, 13672, 1829, 31439, 1737, 1189, 88, 392, 6490, 1742, 404, 18191, 533, 6156, 995, 37983, 9957, 2423, 1742, 404, 18191, 533, 13672, 1829, 1975, 5016, 8315, 11331, 4117, 1829, 8315, 3224, 8978, 2423, 415, 1398, 3185, 282, 5317, 4642, 1975, 5016, 8315, 12174, 12610, 8315, 16472, 3224, 3714, 43020, 7251, 11622, 25708, 8978, 2423, 6497, 37500, 11778, 3224, 31439, 8978, 2423, 6497], "avg_logprob": -0.33795102109614106, "compression_ratio": 1.6586538461538463, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2373.59, "end": 2373.95, "word": "اللي", "probability": 0.4256591796875}, {"start": 2373.95, "end": 2374.17, "word": " هو", "probability": 0.94775390625}, {"start": 2374.17, "end": 2374.35, "word": " الـ", "probability": 0.4532470703125}, {"start": 2374.35, "end": 2375.29, "word": " hemoglobinopathy", "probability": 0.759521484375}, {"start": 2375.29, "end": 2375.73, "word": " or", "probability": 0.2032470703125}, {"start": 2375.73, "end": 2377.17, "word": " تلسينية", "probability": 0.590283203125}, {"start": 2377.17, "end": 2378.45, "word": " طبعا", "probability": 0.8973388671875}, {"start": 2378.45, "end": 2379.15, "word": " الفحص", "probability": 0.8785807291666666}, {"start": 2379.15, "end": 2379.47, "word": " التاني", "probability": 0.9085286458333334}, {"start": 2379.47, "end": 2379.61, "word": " اللي", "probability": 0.559814453125}, {"start": 2379.61, "end": 2379.81, "word": " هو", "probability": 0.97802734375}, {"start": 2379.81, "end": 2380.19, "word": " فب", "probability": 0.361572265625}, {"start": 2380.19, "end": 2380.37, "word": " ال", "probability": 0.3232421875}, {"start": 2380.37, "end": 2380.87, "word": " FEP", "probability": 0.723876953125}, {"start": 2380.87, "end": 2381.31, "word": " اللي", "probability": 0.7156982421875}, {"start": 2381.31, "end": 2381.53, "word": " هو", "probability": 0.98095703125}, {"start": 2381.53, "end": 2381.93, "word": " free", "probability": 0.5009765625}, {"start": 2381.93, "end": 2382.75, "word": " erythroid", "probability": 0.888916015625}, {"start": 2382.75, "end": 2383.79, "word": " protoporphine", "probability": 0.779541015625}, {"start": 2383.79, "end": 2385.09, "word": " فاكرين", "probability": 0.9713134765625}, {"start": 2385.09, "end": 2385.23, "word": " ال", "probability": 0.96826171875}, {"start": 2385.23, "end": 2386.17, "word": " protoporphine", "probability": 0.765625}, {"start": 2386.17, "end": 2387.11, "word": " اللي", "probability": 0.94287109375}, {"start": 2387.11, "end": 2387.47, "word": " احنا", "probability": 0.8834635416666666}, {"start": 2387.47, "end": 2388.11, "word": " حكيناه", "probability": 0.92373046875}, {"start": 2388.11, "end": 2388.23, "word": " في", "probability": 0.9033203125}, {"start": 2388.23, "end": 2388.35, "word": " ال", "probability": 0.97119140625}, {"start": 2388.35, "end": 2388.65, "word": " heme", "probability": 0.52642822265625}, {"start": 2388.65, "end": 2389.43, "word": " cyanophysis", "probability": 0.4398651123046875}, {"start": 2389.43, "end": 2390.97, "word": " احنا", "probability": 0.8771158854166666}, {"start": 2390.97, "end": 2391.33, "word": " قولنا", "probability": 0.802978515625}, {"start": 2391.33, "end": 2392.67, "word": " انه", "probability": 0.830322265625}, {"start": 2392.67, "end": 2393.05, "word": " ممكن", "probability": 0.941162109375}, {"start": 2393.05, "end": 2393.65, "word": " يزيد", "probability": 0.9928385416666666}, {"start": 2393.65, "end": 2396.63, "word": " في", "probability": 0.91015625}, {"start": 2396.63, "end": 2396.77, "word": " ال", "probability": 0.923828125}, {"start": 2396.77, "end": 2397.25, "word": " iron", "probability": 0.76513671875}, {"start": 2397.25, "end": 2398.79, "word": " deficiency", "probability": 0.6064453125}, {"start": 2398.79, "end": 2399.33, "word": " ده", "probability": 0.955810546875}, {"start": 2399.33, "end": 2399.59, "word": " هو", "probability": 0.96044921875}, {"start": 2399.59, "end": 2400.07, "word": " في", "probability": 0.372802734375}, {"start": 2400.07, "end": 2400.07, "word": " ال", "probability": 0.9033203125}, {"start": 2400.07, "end": 2400.47, "word": " iron", "probability": 0.95361328125}], "temperature": 1.0}, {"id": 90, "seek": 241548, "start": 2405.08, "end": 2415.48, "text": "هذا ما يتعلق بالثلاثين نشكر لكم استماعكم وحياكم الله", "tokens": [3224, 15730, 19446, 7251, 2655, 30241, 4587, 20666, 12984, 1211, 5718, 104, 9957, 8717, 8592, 37983, 5296, 24793, 44713, 15042, 3615, 24793, 4032, 5016, 25528, 24793, 21984], "avg_logprob": -0.30608259992940084, "compression_ratio": 1.2, "no_speech_prob": 1.9073486328125e-06, "words": [{"start": 2405.08, "end": 2406.48, "word": "هذا", "probability": 0.31689453125}, {"start": 2406.48, "end": 2407.36, "word": " ما", "probability": 0.453369140625}, {"start": 2407.36, "end": 2407.88, "word": " يتعلق", "probability": 0.95849609375}, {"start": 2407.88, "end": 2408.68, "word": " بالثلاثين", "probability": 0.93994140625}, {"start": 2408.68, "end": 2409.28, "word": " نشكر", "probability": 0.6764322916666666}, {"start": 2409.28, "end": 2409.56, "word": " لكم", "probability": 0.6219482421875}, {"start": 2409.56, "end": 2411.66, "word": " استماعكم", "probability": 0.960205078125}, {"start": 2411.66, "end": 2415.16, "word": " وحياكم", "probability": 0.8045654296875}, {"start": 2415.16, "end": 2415.48, "word": " الله", "probability": 0.95361328125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2431.12925, "duration_after_vad": 2342.668749999995}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..93fa09e0483537a9fe748bdff52d3ab9291d8db8
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_postprocess.srt
@@ -0,0 +1,1848 @@
+1
+00:00:01,470 --> 00:00:05,310
+بسم الله الرحمن الرحيم استكملا لمحاضرة الـ
+
+2
+00:00:05,310 --> 00:00:10,210
+Hemolytic Anemia هنتطلق للـ Acquired Hemolytic
+
+3
+00:00:10,210 --> 00:00:15,690
+Anemia الآن و الـ Acquired Hemolytic Anemia بمعنى
+
+4
+00:00:15,690 --> 00:00:21,170
+أنه فيه ملزمنا Acquired Factor to induce Hemolysis
+
+5
+00:00:21,170 --> 00:00:26,090
+قسموها إلى خمس أقسام يعني Hemolysis secondary to
+
+6
+00:00:26,090 --> 00:00:30,120
+immune mechanismيعني في تفاعل antigen-antibody
+
+7
+00:00:30,120 --> 00:00:34,900
+reaction secondary to action of chemical drugs or
+
+8
+00:00:34,900 --> 00:00:38,840
+toxin دخل chemical أو drug أو toxin secondary to
+
+9
+00:00:38,840 --> 00:00:42,340
+infection صار hemolysis due to infection or
+
+10
+00:00:42,340 --> 00:00:46,700
+secondary to physical damage ضربة or trauma and
+
+11
+00:00:46,700 --> 00:00:51,420
+miscellaneous بمعنى متفرقات برضه اندرجت تحت هذا
+
+12
+00:00:51,420 --> 00:00:55,640
+الموضوع ال immune hemolytic anemia من الإسم هي
+
+13
+00:00:55,640 --> 00:00:59,330
+عبارة عن تفاعل antigen مع antibodyلما بقول immune
+
+14
+00:00:59,330 --> 00:01:03,290
+يعني إيش؟ antigen antibody reaction and this
+
+15
+00:01:03,290 --> 00:01:08,850
+reaction بيعتمد على العوامل الآتية يعني ما يؤثر في
+
+16
+00:01:08,850 --> 00:01:16,370
+هذا التفاعل العوامل الآتية قالوا ال .. نمر واحد
+
+17
+00:01:16,370 --> 00:01:18,970
+class of antibody، شو يعني class؟ يعني نوع ال
+
+18
+00:01:18,970 --> 00:01:20,110
+antibody اللي موجود
+
+19
+00:01:27,140 --> 00:01:31,680
+في عملية ال activation أو ال reaction اللي بدأ
+
+20
+00:01:31,680 --> 00:01:36,860
+يحصل نمرا اتنين number and spacing of antigenic
+
+21
+00:01:36,860 --> 00:01:41,420
+site يعني عدد والمسافة اللي موجودة ما بين ال
+
+22
+00:01:41,420 --> 00:01:43,620
+antigenic site ال antigenic site الموجود فيها ال
+
+23
+00:01:43,620 --> 00:01:48,240
+ab-tops يعني ال antigen المناطق ارتباط ال antigen
+
+24
+00:01:48,240 --> 00:01:53,500
+بال antibody عشان على سطح القضية لكل ما زادت
+
+25
+00:01:53,500 --> 00:02:02,490
+المسافة بين الرواقEpitopes كل ما احتجنا لانتيبادي
+
+26
+00:02:02,490 --> 00:02:09,070
+كبير اي ال IGM عشاناش يتفاعل معاه كل ما قلت
+
+27
+00:02:09,070 --> 00:02:16,130
+المسافة طبعا هذا بيعتمد على العدد كل ما كان ال
+
+28
+00:02:16,130 --> 00:02:21,550
+antibody حتى وكان صغير monomeric يعني ممكن ينشر أو
+
+29
+00:02:21,550 --> 00:02:23,810
+يكسر ال news in monocyte
+
+30
+00:02:57,740 --> 00:03:02,270
+مش بس أنا ناسي الميكروفونإن شاء الله هالجيتر يكون
+
+31
+00:03:02,270 --> 00:03:08,330
+الوضع أحسن يبقى التفاعل بيعتمد على العوامل القاتية
+
+32
+00:03:08,330 --> 00:03:15,450
+نمرا واحد اللي هو ال class of antibody نمرا
+
+33
+00:03:15,450 --> 00:03:19,950
+اتنين يعني ان هو ال antibody هل هو IGM ولا IGG
+
+34
+00:03:19,950 --> 00:03:24,630
+نمرا اتنين ال number هو and spacing of antigenic
+
+35
+00:03:24,630 --> 00:03:30,590
+sites يعني العددوعدد الـ Epitopes والمسافة
+
+36
+00:03:30,590 --> 00:03:33,970
+الموجودة بين الـ Epitopes الـ Epitopes هو عبارة عن
+
+37
+00:03:33,970 --> 00:03:39,170
+مناطق ارتباط الـ Antibody بالـ Antigen ماشي فكل ما
+
+38
+00:03:39,170 --> 00:03:43,550
+كانت ال Epitopes متباعدة كل ما احتجنا ل Antibody
+
+39
+00:03:43,550 --> 00:03:47,610
+كبير عشان يتفاعل معاه وكل ما كانت متقاربة كل ما
+
+40
+00:03:47,610 --> 00:03:52,830
+كان زي ال IGMكل ما كانت متقاربة ال IGG لحد ممكن يش
+
+41
+00:03:52,830 --> 00:03:56,670
+اللي هو ال monomeric antibody ممكن يش يكسر اللي هي
+
+42
+00:03:56,670 --> 00:04:02,190
+ادنوية ال compliment ال compliment لها receptor
+
+43
+00:04:02,190 --> 00:04:10,890
+على سطح خلايا كثيرة فوجود ال antibody وجود ال
+
+44
+00:04:10,890 --> 00:04:13,470
+compliment على سطح خلايا الدم الحمراء كفيل بأنه
+
+45
+00:04:13,470 --> 00:04:20,050
+نشط ال complimentأو في الوسط يعني عفوا وجود
+
+46
+00:04:20,050 --> 00:04:22,810
+الانتيجن antibody reaction هو وجود ال complement
+
+47
+00:04:22,810 --> 00:04:25,850
+في الوسط بنفس ال complement و ال complement كفيلة
+
+48
+00:04:25,850 --> 00:04:30,250
+منها تكسر قلعة الدم الحمراء العامل الرابع ال
+
+49
+00:04:30,250 --> 00:04:32,870
+temperature ال temperature تلعب دور كبير في سرعة
+
+50
+00:04:32,870 --> 00:04:39,410
+التفاعل ثم ال efficiency of reticulum in the cell
+
+51
+00:04:39,410 --> 00:04:43,630
+system شغال ميح ولا لأ اللي هوالـ Spleen أو ما
+
+52
+00:04:43,630 --> 00:04:48,390
+يُعرف بالـ reticulum endothelial system Spleen and
+
+53
+00:04:48,390 --> 00:04:53,550
+liver طيب مانفستيشن كيف بنشوف التفاعل؟ جاله تفاعل
+
+54
+00:04:53,550 --> 00:04:59,530
+محصلة وإما Intravascular Hemorrhage وإما
+
+55
+00:04:59,530 --> 00:05:02,290
+Extravascular Hemorrhage واحنا عرفنا ال
+
+56
+00:05:02,290 --> 00:05:05,430
+Intravascular يعني بيصير تكسير في داخل الوعي دموعي
+
+57
+00:05:05,430 --> 00:05:10,110
+و Extravascular بيصير في secondary lymphoid or
+
+58
+00:05:10,110 --> 00:05:15,310
+reticulum endothelial systemالقاعدة ناخدها في ان
+
+59
+00:05:15,310 --> 00:05:18,850
+اعتبار يما ال antibody ترتبط بال RBCs يعني تجد على
+
+60
+00:05:18,850 --> 00:05:24,490
+سطح ال RBCs لأن ال RBCs على سطحها Antigen فإذا ال
+
+61
+00:05:24,490 --> 00:05:28,210
+antibody مسيك في ال Antigen على سطح كورات الدم
+
+62
+00:05:28,210 --> 00:05:33,610
+الحمراء هيكون في احتمال من اتنين اما هذا التفاعل
+
+63
+00:05:33,610 --> 00:05:38,930
+ينشط ال complement cascade للاخر ومحصلة تكسير
+
+64
+00:05:38,930 --> 00:05:44,470
+كورات الدم الحمراءوإما ان انت بدي بيكون صغير فبيجي
+
+65
+00:05:44,470 --> 00:05:51,670
+بقعد على سطح ال RBCs بس مابيكسرها طب شو بيعمل
+
+66
+00:05:51,670 --> 00:05:56,450
+فيها؟ قالوا بيعلمها لمين؟للـ macrophage اللي في
+
+67
+00:05:56,450 --> 00:05:59,270
+الـ reticular endothelial system فأول ما تصل ..
+
+68
+00:05:59,270 --> 00:06:01,850
+يعني الـ spleen احنا دايما بضرب مثال على ال spleen
+
+69
+00:06:01,850 --> 00:06:06,550
+أول ما تصل ال RBCs لل spleen تتعرف عليه ال
+
+70
+00:06:06,550 --> 00:06:14,870
+macrophage ك abnormal cell و بيكسرها أول بأولطبعاً
+
+71
+00:06:14,870 --> 00:06:18,490
+زي ما اتفقنا إذا كان الاحتمال الأول هو اللي صار
+
+72
+00:06:18,490 --> 00:06:21,790
+بده يصير فيه Intravascular Hemolysis وإذا الاحتمال
+
+73
+00:06:21,790 --> 00:06:25,590
+التاني هو اللي صار بده يصير فيه Extravascular
+
+74
+00:06:25,590 --> 00:06:32,590
+Hemolysis في الخلية. كده لما نخش في ال union
+
+75
+00:06:32,590 --> 00:06:37,170
+Hemolytic Anemia بأنواعها قدوا وقالوا ضروري نتعرف
+
+76
+00:06:37,170 --> 00:06:44,550
+على فحص اسمه Coombs Testوالـ Combs Test هذا فحص
+
+77
+00:06:44,550 --> 00:06:49,530
+نتعرف من خلاله على أو نشخص من خلاله الـ Immune
+
+78
+00:06:49,530 --> 00:06:54,610
+Hemolytic Anemia جابوا و ال Combs Test هو عبارة عن
+
+79
+00:06:54,610 --> 00:06:59,810
+نوعين إما direct و إما indirect فال direct بيدور
+
+80
+00:06:59,810 --> 00:07:03,130
+على immunoglobulin أو complement على سطح كورة الدم
+
+81
+00:07:03,130 --> 00:07:08,230
+الحمراءفي الوضع الطبيعي هذه لا ال antibody ولا ال
+
+82
+00:07:08,230 --> 00:07:15,190
+complement موجود على سطح كولات الدم الحمراء وإذا
+
+83
+00:07:15,190 --> 00:07:17,730
+مولد بالفعل مع ال compulsive agent ال compulsive
+
+84
+00:07:17,730 --> 00:07:21,470
+agent هو عبارة عن خليط من Anti human
+
+85
+00:07:21,470 --> 00:07:26,710
+immunoglobulin يعني Anti antibody و Anti human
+
+86
+00:07:26,710 --> 00:07:31,210
+complement يعني Anti complement فشوية كانت ال
+
+87
+00:07:31,210 --> 00:07:33,970
+immunoglobulin او ال complement بعد على سطح كولات
+
+88
+00:07:33,970 --> 00:07:37,770
+الدم الحمراءلو ضفنا الـ Constant agent هيتفاعل
+
+89
+00:07:37,770 --> 00:07:43,010
+معايدنا agglutination للاربيسيز طبعا إذا صار
+
+90
+00:07:43,010 --> 00:07:46,410
+agglutination مانتويش Const test direct Const test
+
+91
+00:07:46,410 --> 00:07:52,130
+positive ماشي فدل حالة بنكون احنا أثبتنا انه في
+
+92
+00:07:52,130 --> 00:07:56,050
+antibody او complement قاعدة على سطح كنات الدم
+
+93
+00:07:56,050 --> 00:08:02,030
+الحمراء ال indirect احنا بندور على طبعا هي ال
+
+94
+00:08:02,030 --> 00:08:07,600
+direct فده هو هي الاربيسيزعلى سطحها antibody حاطين
+
+95
+00:08:07,600 --> 00:08:10,940
+عليها الكمس reagent صار antibody antibody reaction
+
+96
+00:08:10,940 --> 00:08:17,920
+يعني او antibody Anti antibody reaction عشان و
+
+97
+00:08:17,920 --> 00:08:20,080
+بالتالي صار فيه hallucination وداني positive
+
+98
+00:08:20,080 --> 00:08:25,180
+results ال indirect chemist test احنا بندور فيها
+
+99
+00:08:25,180 --> 00:08:32,460
+على antibody موجودة في ال serum تبع المريض و في
+
+100
+00:08:32,460 --> 00:08:36,080
+هذه الحالةعشان انا اعرف ان في antibody عند مريض
+
+101
+00:08:36,080 --> 00:08:43,740
+معين بدي اخد ال serum تبعه و افحصه بعدد انواع من
+
+102
+00:08:43,740 --> 00:08:48,060
+ال RBC's اللي معروف ال antigen على سطحها
+
+103
+00:08:51,510 --> 00:08:53,830
+وبالتالي إذا الـ Antibody موجود سنقوم بالتفاعل مع
+
+104
+00:08:53,830 --> 00:08:56,190
+الـ Antigen ويصير فيه Antibody-Antibody reaction
+
+105
+00:08:56,190 --> 00:09:01,090
+بعد ذلك بكمل زي ال Direct Combs Test بحط ال Combs
+
+106
+00:09:01,090 --> 00:09:06,910
+Reagent وإذا موجود بدينا تفاعل وهذا التفاعل ده هو
+
+107
+00:09:06,910 --> 00:09:10,610
+بنجيب عدة أنواع من ال RBC's اللي ال Antigen معروف
+
+108
+00:09:10,610 --> 00:09:14,210
+عليها وبنجيب ال patient serum اللي بندير فيه على
+
+109
+00:09:14,210 --> 00:09:17,170
+إيش على Antibody الله إذا ال Antibody الموجود
+
+110
+00:09:17,170 --> 00:09:20,750
+هيصير فيه عيود على سطح كورة الدم الحمراءأنا إذا
+
+111
+00:09:20,750 --> 00:09:24,110
+كان باخد العربيشيز في هذه الحالة و بنحط عليها
+
+112
+00:09:24,110 --> 00:09:28,010
+الكمس رياجين والله إذا كان ال antibody كان موجود
+
+113
+00:09:28,010 --> 00:09:30,890
+وقعد على سطح كورة دم الحوار احدي نجатив reaction
+
+114
+00:09:30,890 --> 00:09:34,270
+إذا ال serum طبع المريض مافيش فيه antibody من
+
+115
+00:09:34,270 --> 00:09:38,090
+الأساس العربيشيز مش راح يكون على سطحها antibody
+
+116
+00:09:38,090 --> 00:09:47,270
+وبالتالي احدي نجатив reaction طيب نبدأ ب ال immune
+
+117
+00:09:47,270 --> 00:09:55,210
+hemolytic anemiaوجاله هي بيندرج تحتها تلت أنواع هي
+
+118
+00:09:55,210 --> 00:10:03,150
+drug related يعني ناجعة عن دخول ال drug or
+
+119
+00:10:03,150 --> 00:10:09,210
+alloimmune دخل سواء antigen او antibody على جسم
+
+120
+00:10:09,210 --> 00:10:19,110
+المريض او autoimmune ماشي طب نرجع مرة تانيةنعود
+
+121
+00:10:19,110 --> 00:10:21,210
+مرة أخرى ونقول لكم الـ Immune-Hemolytic-Anemia
+
+122
+00:10:21,210 --> 00:10:25,290
+تنقسم إلى تلت أنواع إما Drug-Related وإما
+
+123
+00:10:25,290 --> 00:10:29,630
+Alloimmune Alloimmune يعني فيه إشي جامل برا وإما
+
+124
+00:10:29,630 --> 00:10:31,910
+Autoimmune Antibody that generates for self
+
+125
+00:10:31,910 --> 00:10:36,530
+-antigen طبعا كل واحدة مقسمة إلى أنواع معينة نتفرق
+
+126
+00:10:36,530 --> 00:10:43,570
+إليهم أول هذه الأنواع هي ال Drug-Related أيضا
+
+127
+00:10:43,570 --> 00:10:47,490
+قسموها إلى تلت أنواعكانوا إما Immune Complex
+
+128
+00:10:47,490 --> 00:10:51,530
+Mechanism يعني تكون Antibody reaction وإما Haptic
+
+129
+00:10:51,530 --> 00:10:58,290
+Immune Mechanism وإما Autoimmune Mechanism وهي
+
+130
+00:10:58,290 --> 00:11:01,290
+الدراجز اللي بتعمل أمثلة على دراجز بتعمل هذه
+
+131
+00:11:01,290 --> 00:11:07,050
+الشغلات ونبدأ بأول نوع Immune Complex Mechanism شو
+
+132
+00:11:07,050 --> 00:11:11,390
+اللي بيحصل؟ بيخش الدراجبمجرد انتبادي موجود في
+
+133
+00:11:11,390 --> 00:11:14,390
+البلازمه بيرتبط معاه بيتكوّن Immune Complex
+
+134
+00:11:14,390 --> 00:11:18,610
+Disimmune Complex إما بنشرت ال complement في
+
+135
+00:11:18,610 --> 00:11:22,230
+البلازمه وبعمل Intravascular Hemolysis وإما بيبقى
+
+136
+00:11:22,230 --> 00:11:28,390
+على سطح كوريات الدم الحمراء وبيعلمها ماشي
+
+137
+00:11:28,390 --> 00:11:31,650
+يوم ما يعلمها بيبقى تعرف عليها reticulum
+
+138
+00:11:31,650 --> 00:11:35,890
+endothelial system ويصير فيه Extravascular
+
+139
+00:11:35,890 --> 00:11:41,230
+Hemolysis Innocentby standard destruction of
+
+140
+00:11:41,230 --> 00:11:44,150
+immune complex بمعنى الخلايا البريئة اللي قعد
+
+141
+00:11:44,150 --> 00:11:50,550
+عليها ال antibody in the complex وبالتالي صارت غير
+
+142
+00:11:50,550 --> 00:11:55,010
+طبيعية عشان يصير التفاعل هذا it requires drugs in
+
+143
+00:11:55,010 --> 00:12:00,170
+the system إذا شو اللي بيصير بدخل ال drug بيلاقي
+
+144
+00:12:00,170 --> 00:12:04,330
+antibody ال antibody الجسم بيعمل ال drug ك antigen
+
+145
+00:12:04,630 --> 00:12:08,670
+فبصير فيه Antibody reaction بيتكوّن immune complex
+
+146
+00:12:08,670 --> 00:12:12,510
+بقعد على سطح كورات الدم الحمراء بتصير كورات الدم
+
+147
+00:12:12,510 --> 00:12:18,010
+الحمراء هذه غير طبيعية فبصير عندنا احتمال من اتنين
+
+148
+00:12:18,010 --> 00:12:22,530
+يا اما بيكون big reaction و بيكسر ال RBC ع المطرح
+
+149
+00:12:22,530 --> 00:12:28,340
+Intravascular يا اما بكون التفاعلبـ Antibody صغير
+
+150
+00:12:28,340 --> 00:12:31,320
+فبيعلّم كورات الدم الحمراء تتعرف عليها الـ
+
+151
+00:12:31,320 --> 00:12:33,900
+reticulum endothelial system وتكسّرها
+
+152
+00:12:33,900 --> 00:12:38,340
+Extravascular التفاعل بيصير إما Intra وإما
+
+153
+00:12:38,340 --> 00:12:44,200
+Extravascular واللي بيحدد ذلك هو نوع الـ Antibody
+
+154
+00:12:44,200 --> 00:12:52,140
+اللي دخل التفاعل المرة التانية هي الـ Haptic
+
+155
+00:12:52,140 --> 00:12:59,690
+Mechanism من الاسم Hapticهو عبارة عن أنتجن صغير لا
+
+156
+00:12:59,690 --> 00:13:06,430
+يستطيع ال stimulation of immune complex immune
+
+157
+00:13:06,430 --> 00:13:10,550
+reaction فعشان يصير في immune reaction يعني
+
+158
+00:13:10,550 --> 00:13:14,090
+antigen، antibody reaction بروح و مكبر حاله، إيش
+
+159
+00:13:14,090 --> 00:13:18,610
+بيعمل؟ باتبع ال drug اللي دخل، يبقى في عندنا في
+
+160
+00:13:18,610 --> 00:13:22,670
+الأساس عندنا protein
+
+161
+00:13:24,950 --> 00:13:28,470
+موجود على سطح كرات الدم الحمراء الـ cell membrane
+
+162
+00:13:28,470 --> 00:13:33,490
+دخل الدراج ارتبط في البروتين الدراج يعتبر كهابتين
+
+163
+00:13:33,490 --> 00:13:38,370
+الدراج يعتبر كهابتين ارتبط في بروتينات سطح كرات
+
+164
+00:13:38,370 --> 00:13:47,210
+الدم الحمراء فبيكبر فبيصير انتجن وبيتكون
+
+165
+00:13:47,210 --> 00:13:51,850
+له antibody which can recognize the haptin اللي هو
+
+166
+00:13:51,850 --> 00:13:57,680
+الدراجو البروتين اللي تمسك فيه و التاني مع بعض
+
+167
+00:13:57,680 --> 00:14:03,660
+يعني الانتيبادي يتفاعل مع التلات أنواع نفس الحكاية
+
+168
+00:14:03,660 --> 00:14:10,620
+التفاعل هذا هيؤدي لتكسير جرعة الدم الحمراء النوع
+
+169
+00:14:10,620 --> 00:14:15,900
+التالت اللي هو true auto antibody formation true
+
+170
+00:14:15,900 --> 00:14:19,400
+auto antibody يعني الانتيبادي بيتفاعل مع self
+
+171
+00:14:19,400 --> 00:14:24,630
+-antigenأولي دي موجودة في الجسم بشكل طبيعي
+
+172
+00:14:24,630 --> 00:14:29,390
+فبيتكوّن Antibody إله شو اللي بيستحث تكوين ال
+
+173
+00:14:29,390 --> 00:14:32,570
+Antibody جاله دخول Drug في بعض أنواع من ال Drug
+
+174
+00:14:32,570 --> 00:14:40,410
+بتسبب أو بتخلي ال Antibody تتفاعل مع مين مع
+
+175
+00:14:40,410 --> 00:14:44,050
+Antigenات أولي دي موجودة في الجسم بشكل طبيعي طب
+
+176
+00:14:44,050 --> 00:14:46,650
+ليش؟ قالوا لأ إنه لما بيجي ال Drug بيقعد عليها
+
+177
+00:14:46,650 --> 00:14:51,360
+بيغيرهافلما تغير شكلها بيعتبر الجسم بيعتبرها جسم ك
+
+178
+00:14:51,360 --> 00:14:55,420
+antigen فبتفعل معاها ك antigen لو جيت ال antibody
+
+179
+00:14:55,420 --> 00:14:58,760
+اللي بتكون بتفعل مع ال drug و بتفعل مع ال protein
+
+180
+00:14:58,760 --> 00:15:04,880
+و بتفعل مع ال both مع التنين مع بعض يجي مرة تانية
+
+181
+00:15:04,880 --> 00:15:12,140
+antibody موجود في الجسم ما بتفعل مع self-antigen
+
+182
+00:15:12,140 --> 00:15:17,560
+لكن لما بدخل الدراجوبرتبط مع بروتينات معينة بيبقى
+
+183
+00:15:17,560 --> 00:15:22,460
+على سطح كورة الدم الحمراء بين جثين بيغير في هذا
+
+184
+00:15:22,460 --> 00:15:25,280
+البروتين فال antibody بيتعرف عليه ك foreign
+
+185
+00:15:25,280 --> 00:15:27,580
+antigen ال antibody already موجود؟ already موجود
+
+186
+00:15:27,580 --> 00:15:32,200
+لكنه بيتعرف عليه كاش؟ ك foreign antigen وبتفعل
+
+187
+00:15:32,200 --> 00:15:39,760
+معاه وبتفعل مع ال drug وبتفعل مع مين؟ مع both طبع
+
+188
+00:15:39,760 --> 00:15:41,280
+المحصلة Hemolysis
+
+189
+00:15:43,750 --> 00:15:47,170
+النوع التاني من الـ Immune Hemolytic Anemia هو الـ
+
+190
+00:15:47,170 --> 00:15:52,450
+Alloimmune نقول ده الـ Drug Related التاني هو
+
+191
+00:15:52,450 --> 00:15:55,910
+Alloimmune و Alloimmune أحسن مثال عليه Hemolytic
+
+192
+00:15:55,910 --> 00:16:00,410
+Transfusion Reaction يعني التفاعلات الناتجة عن
+
+193
+00:16:00,410 --> 00:16:05,170
+عمليات نقل الدم و جاروا هذه تلت أنواع النوع
+
+194
+00:16:05,170 --> 00:16:08,710
+الأولاني بيسموه Immediate Intravascular Hemolysis
+
+195
+00:16:08,710 --> 00:16:13,850
+Immediate يعني على المطرحin blood vessels هنا
+
+196
+00:16:13,850 --> 00:16:18,570
+تكسير الكولات الدم الحمراء and it takes a few
+
+197
+00:16:18,570 --> 00:16:23,590
+minutes to occur and it's life threatening بمعنى
+
+198
+00:16:23,590 --> 00:16:29,710
+يعني مقاتل إذا صار المريض ممكن يلتحق وممكن ما
+
+199
+00:16:29,710 --> 00:16:36,060
+يلتحق ماشي شو السبب قالوا هذا النوع بيكونعبارة عن
+
+200
+00:16:36,060 --> 00:16:41,260
+غلطة في الفصيلة نوع الفصيلة الفصيلة هي عبارة عن
+
+201
+00:16:41,260 --> 00:16:44,780
+انتيجينات جاعدة على سطح كورة الدم الحمراء هي التي
+
+202
+00:16:44,780 --> 00:16:48,640
+تحدد الفصيلة ال naturally occurring antibody
+
+203
+00:16:48,640 --> 00:16:54,380
+تبعتها هي عبارة عن big antibody IGM فالتفاعل بيكون
+
+204
+00:16:54,380 --> 00:16:59,200
+مع big antigen ال antibody تفاعلت مع big antigen
+
+205
+00:16:59,200 --> 00:17:02,350
+فهو عبارة عن strong reactionبيحصل في الـ
+
+206
+00:17:02,350 --> 00:17:08,650
+Intravascular Hemorrhage بسيطة
+
+207
+00:17:08,650 --> 00:17:11,170
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+208
+00:17:11,170 --> 00:17:11,870
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+209
+00:17:11,870 --> 00:17:12,090
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+210
+00:17:12,090 --> 00:17:12,130
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+211
+00:17:12,130 --> 00:17:20,170
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+212
+00:17:20,170 --> 00:17:25,930
+بسيطة
+
+213
+00:17:25,930 --> 00:17:30,130
+بسيط
+
+214
+00:17:31,110 --> 00:17:36,530
+انه دخل الـ Antigen بس الـ Antigen هذا هو عبارة عن
+
+215
+00:17:36,530 --> 00:17:41,630
+الـ Rh المرة هذه الـ Rh ال Immunogenesis تبعته أقل
+
+216
+00:17:41,630 --> 00:17:51,070
+من الـ ABO فالـ Rh دخل قبل هيك و يتحمل الجسم لكن
+
+217
+00:17:51,070 --> 00:17:55,110
+كونله Antibody فصار فى Antibody جاهز لمين؟ لهذا
+
+218
+00:17:55,110 --> 00:17:58,870
+الـ Antigen اليوم نعيد الكره مرة تانية و ندخل الـ
+
+219
+00:17:58,870 --> 00:18:03,140
+Rh Antigenمرة تانية بيكون ال antibody already
+
+220
+00:18:03,140 --> 00:18:07,220
+موجود وال antibody تبع ال Rh هو من نوع IgG
+
+221
+00:18:07,220 --> 00:18:11,440
+فالاتفاع اللي بيكون ياش بيقدرش ينشط ال complement
+
+222
+00:18:11,440 --> 00:18:16,120
+للآخر فبيقعد بيعمل optimization مين بتعرف عليه ال
+
+223
+00:18:16,120 --> 00:18:18,800
+secret endothelial system يعني ال spleen يعني
+
+224
+00:18:18,800 --> 00:18:22,380
+extravascular hemolysis وين بيصير؟ في ال spleen
+
+225
+00:18:22,380 --> 00:18:23,800
+extravascular
+
+226
+00:18:25,460 --> 00:18:30,460
+إنه التالت هو بيسموه delayed sensitization it
+
+227
+00:18:30,460 --> 00:18:37,260
+takes weeks على خلاف التاني اللي بياخد أيام التالت
+
+228
+00:18:37,260 --> 00:18:41,000
+بياخد weeks بياخد ايش أسابيع عشان أسير وغالبا
+
+229
+00:18:41,000 --> 00:18:45,560
+بيكون due to exposure to foreign antigen and it's
+
+230
+00:18:45,560 --> 00:18:49,740
+asymptomatic في البداية غالبا بيكون البلازمة تبعت
+
+231
+00:18:49,740 --> 00:18:55,400
+الدم اللي مانقول فيها protein معينلكنه هذا
+
+232
+00:18:55,400 --> 00:18:59,720
+البروتين جسم
+
+233
+00:18:59,720 --> 00:19:04,720
+بيعتبره antigen فبعمل reaction بس بحركة بطيقة يعني
+
+234
+00:19:04,720 --> 00:19:11,780
+بشويه ماشي فبصير فيه تفاعل لكن التفاعل هذا بتتم
+
+235
+00:19:11,780 --> 00:19:16,540
+بعد ايش؟ بعد أسابيع وهي ال rate of hemolysis زي ما
+
+236
+00:19:16,540 --> 00:19:21,900
+انتوا شايفين هذا ال normal الأحمر لما ببجوا الدم
+
+237
+00:19:24,020 --> 00:19:29,740
+سليم المفروض ان الاربيسي تعيش بالعمر الطبيعي تبعته
+
+238
+00:19:29,740 --> 00:19:36,260
+النوع الأولاني هو ال immediate اللي هو at zero
+
+239
+00:19:36,260 --> 00:19:42,880
+time بيصير فيه hemolysis النوع التاني اللي هو due
+
+240
+00:19:42,880 --> 00:19:46,880
+to heritage it takes days هذا هو slow
+
+241
+00:19:46,880 --> 00:19:50,440
+extravascular hemolysis وهذا النوع الأزرق اللي هو
+
+242
+00:19:50,440 --> 00:19:54,210
+آخر نوعاللي هو delete extravascular hemolysis
+
+243
+00:19:54,210 --> 00:20:02,130
+اسمين بيكسر slow reaction يعني يصير طيب
+
+244
+00:20:02,130 --> 00:20:07,530
+شو لازم اعمل عشان التلافة هذا النوع من التفاعل ده
+
+245
+00:20:07,530 --> 00:20:10,350
+اللي بدك تعمل pre-transplant testing بدك تفحص
+
+246
+00:20:10,350 --> 00:20:15,710
+الفصيلة صح تفحص ال Rh صح for both donor and
+
+247
+00:20:15,710 --> 00:20:20,090
+recipient مستقبل والإياج والمتبرئ
+
+248
+00:20:21,900 --> 00:20:27,380
+و يتدور على فتنين تعمل antibody screening تدور على
+
+249
+00:20:27,380 --> 00:20:32,740
+antibody for bothوهذا بنعمله طبعا بالـ Indirect
+
+250
+00:20:32,740 --> 00:20:35,280
+Comst Test لأن اتفقنا على أنه إذا بدك تدور على
+
+251
+00:20:35,280 --> 00:20:39,320
+Antibody في Serum بدك تدور على تعمل Indirect Comst
+
+252
+00:20:39,320 --> 00:20:42,080
+Test هذا التجارب الحالية بيسموها Major Crossmatch
+
+253
+00:20:42,080 --> 00:20:44,040
+ان شاء الله حتى هاخدوه الكلام هذا في بنك الدم
+
+254
+00:20:44,040 --> 00:20:48,880
+بالتفصيل وهذا برضه نفس الحكاية بيخلطوا ال
+
+255
+00:20:48,880 --> 00:20:52,880
+recipient serum مع ال donor RBCs عشان يشوفوا بيصير
+
+256
+00:20:52,880 --> 00:20:57,720
+فيه تفاعل ولا لأ يعني بيشوفوا عملية نقل الدم in
+
+257
+00:20:57,720 --> 00:20:59,460
+retro إيش بده يصير فيها
+
+258
+00:21:02,250 --> 00:21:07,810
+المثال الآخر للـ Alloimmune هو أيضًا مثال حقيقي هو
+
+259
+00:21:07,810 --> 00:21:11,510
+الـ hemolytic disease of newborn كلكم سمعتوا بالـ
+
+260
+00:21:11,510 --> 00:21:16,110
+hemolytic disease of newborn هو إيش اللي بيصير؟
+
+261
+00:21:16,110 --> 00:21:21,970
+قالوا بيصير incompatibility بين الإم ك negative
+
+262
+00:21:21,970 --> 00:21:28,770
+for antigen وبين الفيتس اللي ماخد انتجنات من أبوه
+
+263
+00:21:28,770 --> 00:21:35,530
+positive for antigenوالانتيجين ممكن يكون RH وممكن
+
+264
+00:21:35,530 --> 00:21:44,150
+يكون ABO ماشي فشو اللي بصير احكيلكوا الحدوث هي كان
+
+265
+00:21:44,150 --> 00:21:48,410
+بالمجمل اللي بصير وناخد مثال على ال RH اللي بصير
+
+266
+00:21:48,410 --> 00:21:52,130
+ان ال RH تبع ال أم negative ال RH تبع ال baby
+
+267
+00:21:52,130 --> 00:21:56,950
+positive اللي في بطنها فشو اللي بصير اللي بصير انه
+
+268
+00:21:56,950 --> 00:22:05,270
+عند ولادةو عند قطع الحبل السريري تدخل شوية RBCs من
+
+269
+00:22:05,270 --> 00:22:11,450
+البيولي عالمين على دم الأم فبيبدأ الجسم يكوّن لها
+
+270
+00:22:11,450 --> 00:22:17,130
+antibody وما أن ال RH مثالنا على ال RH قلنا ان ال
+
+271
+00:22:17,130 --> 00:22:22,770
+antibody تبع ال RH من نوع IGGفبدّى عند الأم في
+
+272
+00:22:22,770 --> 00:22:27,830
+دمها تواجد الـ Antibody اللى هو تبع الـ Rh و اللى
+
+273
+00:22:27,830 --> 00:22:34,390
+هو منه IGG فى الحمض التانى أو ممكن اللى بعده أو
+
+274
+00:22:34,390 --> 00:22:39,730
+اللى بعده ماشي فى الحمض التانى إذا اختلف إذا إجا
+
+275
+00:22:39,730 --> 00:22:44,870
+الجمين برضه مختلف عن الأم ال Antibody اللى اتكونت
+
+276
+00:22:44,870 --> 00:22:48,850
+للـ Rh بإيكروكاميكروستابلاسينتا
+
+277
+00:22:49,510 --> 00:22:53,010
+وبتدخل على ال baby التاني وبتغطله لأنه بيصير فيه
+
+278
+00:22:53,010 --> 00:22:58,110
+Antibody reaction وHemolysis لل RBCs of the baby
+
+279
+00:22:58,110 --> 00:23:04,350
+والمحصلة يعني death العملية
+
+280
+00:23:04,350 --> 00:23:07,730
+زي ما اتفقنا it requires maternal IgG لازم يخش
+
+281
+00:23:07,730 --> 00:23:12,110
+versus antigen in the fetus وزي ما انتوا شايفين
+
+282
+00:23:12,110 --> 00:23:16,340
+بيصير حاجة بيسموها erythroplastosis fetalisيعني
+
+283
+00:23:16,340 --> 00:23:20,400
+still birth يعني ال baby بيموت في بطن أمه بهذا
+
+284
+00:23:20,400 --> 00:23:27,600
+الشكل وهي بيصير فيه edema يعني
+
+285
+00:23:27,600 --> 00:23:33,220
+as a result of heart failure وبيتضخم ال baby بهذا
+
+286
+00:23:33,220 --> 00:23:41,360
+الشكل وغالبا تبدو بيصير فيه difficult اللي هو
+
+287
+00:23:41,360 --> 00:23:45,560
+delivery وفي الغالب بتكون cesarean
+
+288
+00:23:48,890 --> 00:23:52,490
+طبعاً زي ما اتفقنا ان الـ it can cause severe
+
+289
+00:23:52,490 --> 00:23:56,070
+anemia in the fetus, erythroplastosis and heart
+
+290
+00:23:56,070 --> 00:24:00,210
+failure بيصير عند ال baby hyperbaleropenia وهذه
+
+291
+00:24:00,210 --> 00:24:06,030
+بتأدي إلى brain damage و بيصير في إذا كان الموضوع
+
+292
+00:24:06,030 --> 00:24:09,590
+due to our etching compatibility العملية ممكن تنحل
+
+293
+00:24:09,590 --> 00:24:14,930
+تماما من خلال إعطاء الأم إبرة اللي هي بيسموها Anti
+
+294
+00:24:14,930 --> 00:24:29,000
+-D أو AntiAnti-Rh ماشي فبالتالي Anti-Rh D وبالتالي
+
+295
+00:24:29,000 --> 00:24:33,580
+بيصير في Blocking لل Antibody اللي بتكون وبنمنع
+
+296
+00:24:33,580 --> 00:24:37,160
+تكوين Antibody وبالتالي ما بنقل لل baby في
+
+297
+00:24:37,160 --> 00:24:40,160
+المستقبل
+
+298
+00:24:42,160 --> 00:24:48,880
+هذا النوع الأول هو النوع التاني من ال .. من ال ..
+
+299
+00:24:48,880 --> 00:24:51,880
+من الimmune hemolytic anemia النوع التالد يسمى
+
+300
+00:24:51,880 --> 00:24:57,260
+autoimmune و ال autoimmune يعني auto antibody من
+
+301
+00:24:57,260 --> 00:25:05,860
+داخل الجسم يتفاعل مع اللي هو self antigen مع self
+
+302
+00:25:05,860 --> 00:25:11,400
+RBCs غالباهذا النوع من ال antibody can fix the
+
+303
+00:25:11,400 --> 00:25:16,980
+complement and
+
+304
+00:25:16,980 --> 00:25:26,300
+set on RBCs وبالتالي بعمل RBCs destruction غالبا
+
+305
+00:25:26,300 --> 00:25:28,800
+associated with lymphoproliferative disease يعني
+
+306
+00:25:28,800 --> 00:25:32,720
+بيكون as a secondary بيكون كcomplication of مرض
+
+307
+00:25:32,720 --> 00:25:35,920
+تاني زي ال lymphoproliferative disease ان شاء الله
+
+308
+00:25:35,920 --> 00:25:41,010
+هتتطلق اليهم قدامأو الـ Collagen Vascular Disease
+
+309
+00:25:41,010 --> 00:25:46,270
+قسموهم إلى نوعين الـ Warm-type و الـ Cold-type الـ
+
+310
+00:25:46,270 --> 00:25:50,990
+Warm-type هو الـ Antibody يكون من نوع IGG و يمكنك
+
+311
+00:25:50,990 --> 00:25:56,810
+إصلاح الـ Complement لكن ليس للآخر بنشطة الـ
+
+312
+00:25:56,810 --> 00:26:02,110
+Complement لغاية C3 يعني لنص التفاعل و بقعد الـ
+
+313
+00:26:02,110 --> 00:26:04,750
+Immunoglobulin binding و cure at all تم نشر في
+
+314
+00:26:04,750 --> 00:26:11,790
+جميع انحضرات الحرارةوبما أن الـ Antibody الـ C3P
+
+315
+00:26:11,790 --> 00:26:15,250
+اللي هي بنحكي عليها أو ال Antibody اللي هو ال Fc
+
+316
+00:26:15,250 --> 00:26:23,530
+Portion أو IGG هو عبارة عن انه ريسبتول على سطح ال
+
+317
+00:26:23,530 --> 00:26:28,730
+macro phage فبتتعرف على اللي هو ال complement أو
+
+318
+00:26:28,730 --> 00:26:33,450
+ال Fc Portion تبع ال Antibody وبيصير فيه Hemolysis
+
+319
+00:26:33,450 --> 00:26:40,050
+لكن Extravascularلأن الـ Antibody صغير و لا يستطيع
+
+320
+00:26:40,050 --> 00:26:47,250
+ان يكسر في داخل الوعاء الدموي 70% من الحالات هذه
+
+321
+00:26:47,250 --> 00:26:52,170
+بتكون associated with other illness منها هي
+
+322
+00:26:52,170 --> 00:26:58,010
+responsive to steroid او splenectomy من صفاتها
+
+323
+00:26:58,010 --> 00:27:02,940
+يعني انه it can respond للعلاجاللي هو الـSteroid
+
+324
+00:27:02,940 --> 00:27:06,620
+اللي هو Immune Suppressant Drug أو إنه نشيل
+
+325
+00:27:06,620 --> 00:27:09,240
+الـSpleen لأن الـSpleen اللي بيصير فيه تكسير
+
+326
+00:27:09,240 --> 00:27:15,320
+الـCold Type mostly الـAntibody هو IgM برتبط في
+
+327
+00:27:15,320 --> 00:27:20,440
+درجات حرارة متدنية لأن اسمه Cold Type يعني في
+
+328
+00:27:20,440 --> 00:27:25,200
+تلاتين وأقل ويستطيع أن يرتبط أو ينشط الـComplement
+
+329
+00:27:25,200 --> 00:27:30,700
+كاملاًوهذا بيؤدي إلى تكوين الـ Membrane Attack
+
+330
+00:27:30,700 --> 00:27:35,140
+Complex وهي آخر مرحلة من مراحل نشاط الـ Complement
+
+331
+00:27:35,140 --> 00:27:41,640
+وهذا بيؤدي إلى الـ RBC Slices طبعاً لازم الـ
+
+332
+00:27:41,640 --> 00:27:47,480
+Complement تكون موجودة 90% من الحالات associated
+
+333
+00:27:47,480 --> 00:27:53,660
+with other illness وبيتستجيب هذه الحالات للستيرويد
+
+334
+00:27:53,660 --> 00:27:58,450
+أو Splenectomyأو بعض المرات بيعملوا حاجة بيسموها
+
+335
+00:27:58,450 --> 00:28:04,590
+plasma pharesis بيفصلوا كمية من البلازمه لأن ال
+
+336
+00:28:04,590 --> 00:28:11,510
+antibody وين موجود في البلازمه summary هو ان
+
+337
+00:28:11,510 --> 00:28:15,430
+التفاعل المحصلة
+
+338
+00:28:15,430 --> 00:28:17,890
+في الhemolytic انه يحصل فيه تكسير لكولات الدم
+
+339
+00:28:17,890 --> 00:28:24,770
+الحمراء البنمره شغال منيحلكن يتطلب اكترا فولك أسب
+
+340
+00:28:24,770 --> 00:28:28,510
+لتصنيع الـ hematopoiesis فولك أسب لازم نلاقيه في
+
+341
+00:28:28,510 --> 00:28:41,170
+تصنيع ال RBCs و أي شيء بيسكر ال bone marrow بيؤدي
+
+342
+00:28:41,170 --> 00:28:47,490
+إلى طبعا acute life threatening anemia أي شيء turn
+
+343
+00:28:47,490 --> 00:28:54,270
+off يعني بطفي ال bone marrowبيؤدي إلى حالة رضية
+
+344
+00:28:54,270 --> 00:28:59,890
+فظيعة أخر نوع من هذه الأنواع قلنا من أنواع الميون
+
+345
+00:28:59,890 --> 00:29:02,750
+هيموريتيك أنيميا قلنا ال miscellaneous type و ال
+
+346
+00:29:02,750 --> 00:29:06,370
+miscellaneous type هو النوع الخامس هه تحت في ال
+
+347
+00:29:06,370 --> 00:29:10,050
+classification بدنا ناخد مثال عليه هو ال Paroxymal
+
+348
+00:29:10,050 --> 00:29:14,110
+Nocturnal Hemoglobinuria Paroxymal Nocturnal
+
+349
+00:29:14,110 --> 00:29:20,110
+Hemoglobinuria و من الإسم Paroxymal معناته sudden
+
+350
+00:29:21,650 --> 00:29:25,470
+nocturnal يعني في الليلة Hemoglobin و urine يعني
+
+351
+00:29:25,470 --> 00:29:30,950
+blood and urine والاسم جاء من أين؟ جاله لأنه من ال
+
+352
+00:29:30,950 --> 00:29:34,830
+symptoms of disease شو اللي بيصير؟ جاله اللي بيصير
+
+353
+00:29:34,830 --> 00:29:41,330
+انه بيصير nocturnal hemolysis يعني تكسير لل RBCs
+
+354
+00:29:41,330 --> 00:29:46,130
+ليلي طبعا لما تتكسر ال RBCs بتنزل في ال .. بتروح
+
+355
+00:29:46,130 --> 00:29:49,600
+الكدنى و بتنزل في ال urineوهذا الكلام لم يقتش بس
+
+356
+00:29:49,600 --> 00:29:54,400
+يرجع له during sleep هو نايم ال baby أو الطفل
+
+357
+00:29:54,400 --> 00:30:00,140
+المصاب و هو نايم بس بيصبح ايش او بيصير عنده
+
+358
+00:30:00,140 --> 00:30:04,380
+nocturnal hemorrhosis و بيقولوا في البداية كانوا
+
+359
+00:30:04,380 --> 00:30:10,040
+يقولوا ان السبب الأساسي لهذا الموضوع هو drop in
+
+360
+00:30:10,040 --> 00:30:16,520
+plasma BH during night لكن اليوم يعني مع تطور
+
+361
+00:30:16,520 --> 00:30:22,340
+العلمثبت إنه مش هذا هو السبب لهذا المرض طب هالاشي
+
+362
+00:30:22,340 --> 00:30:25,680
+البروزيومال نكتورنال hemoglobinuria كان هو عبارة
+
+363
+00:30:25,680 --> 00:30:31,920
+عن acquired clonal disorder ايش يعني acquired
+
+364
+00:30:31,920 --> 00:30:38,160
+مكتسب clonal يعني clone of cell ماشي disordered
+
+365
+00:30:38,160 --> 00:30:44,940
+كله مصعب يكون ايش نوع الإصابة كان نتيجة somatic
+
+366
+00:30:44,940 --> 00:30:50,680
+mutationعلى مستوى الـ Multipotential Stem Cell شو
+
+367
+00:30:50,680 --> 00:30:58,780
+صار فيها؟ قالوا تخلقت RBCs susceptible يعني بتتأثر
+
+368
+00:30:58,780 --> 00:31:04,520
+بالـ Lytic Action of Complement مش محمية RBCs
+
+369
+00:31:04,520 --> 00:31:09,880
+الطبيعية بتكون محمية من نشاط الـ Complement في
+
+370
+00:31:09,880 --> 00:31:13,880
+الوضع الطبيعي الـ Complement هي أداة من أدوات الـ
+
+371
+00:31:13,880 --> 00:31:18,760
+Immune Systemما بتتنشط إلا في وجود Antigen أو
+
+372
+00:31:18,760 --> 00:31:25,440
+Antigen Antibody reaction ماشي لكن لو وجدت تتنشط
+
+373
+00:31:25,440 --> 00:31:29,600
+في الوضع الطبيعي على سطح كورات دم حمراء تغري كورات
+
+374
+00:31:29,600 --> 00:31:34,600
+الدم الحمراء تملع نشاطها في الوضع الطبيعي لكن في
+
+375
+00:31:34,600 --> 00:31:39,720
+هذا النوع من المرض بتتخلق ال RBC من البنمرو فيها
+
+376
+00:31:39,720 --> 00:31:44,420
+عيب ايش العيب قالوا انه واللهSusceptible يعني
+
+377
+00:31:44,420 --> 00:31:51,440
+معرضة لتكسير بواسطة ال compliment شو المحصلة في
+
+378
+00:31:51,440 --> 00:31:55,100
+هذا الحالة؟ بيصير فيه chronic مزمنها but ابو صدق
+
+379
+00:31:55,100 --> 00:32:02,160
+لكن على مستوى نوبات Intravascular Hemolysis mostly
+
+380
+00:32:02,160 --> 00:32:06,500
+occur during sleep moderately to severe
+
+381
+00:32:06,500 --> 00:32:10,880
+panhypoplasia إيش ال panhypoplasia؟ pan يعني كل
+
+382
+00:32:11,210 --> 00:32:16,090
+هيبو قلة بلايزيا تصنيع وبالتالي صار في قلة في
+
+383
+00:32:16,090 --> 00:32:20,230
+تصنيع كل أنواع عياش الخلالية neutrophil
+
+384
+00:32:20,230 --> 00:32:24,590
+dysfunction كمان مش بس ال herpes Z تطلع مخلقة يعني
+
+385
+00:32:24,590 --> 00:32:29,450
+خطأ وانما كمان ال neutrophil تكون مش شغالة renal
+
+386
+00:32:29,450 --> 00:32:33,310
+insufficiency بيصير مع المريض as a complication
+
+387
+00:32:33,310 --> 00:32:38,610
+لهذا المرض ان الكدن بتضرب عنده and dysphagia بيصير
+
+388
+00:32:38,610 --> 00:32:42,970
+فيه صعوبة في البلعبوغالبا بيصير عنده venous
+
+389
+00:32:42,970 --> 00:32:51,570
+thrombosis جلطات في إيش في ال vein classification
+
+390
+00:32:51,570 --> 00:32:55,550
+قسموها بشكل عام لثلاث أنواع كانت P and H واحد
+
+391
+00:32:55,550 --> 00:33:00,890
+واثنين وثلاثة واحد تكون normal واثنين show
+
+392
+00:33:00,890 --> 00:33:05,630
+moderate increased sensitivity وثلاثةالـ
+
+393
+00:33:05,630 --> 00:33:10,250
+sensitivity to compliment بتكون markedly increased
+
+394
+00:33:10,250 --> 00:33:15,270
+طب كيف؟ كدهش بيصير التكسير يعني التكسير بيكون
+
+395
+00:33:15,270 --> 00:33:20,170
+ملحوظ تماما في النوع التالت كدهش بيكون الاربس
+
+396
+00:33:20,170 --> 00:33:23,450
+يتكسر اتجاهله اذا اتكسر خمسين فالمية فما فوق فهو
+
+397
+00:33:23,450 --> 00:33:29,880
+بيانعج تلاتة ماشي؟في بعض الكتب قالوا ان التكسير
+
+398
+00:33:29,880 --> 00:33:34,360
+بين عشرين لخمسين في المية من ال circulating RBCs
+
+399
+00:33:34,360 --> 00:33:40,580
+يعتبر PNH تلاتة pathogenesis شو اللي صار؟ ليش هذه
+
+400
+00:33:40,580 --> 00:33:46,320
+الخلايا صارت معرضة للتكسير بواسطة الكمجمن لما اجوا
+
+401
+00:33:46,320 --> 00:33:50,560
+فحصوها لجوا ان في عندها نخص في بعض البروتينات اللي
+
+402
+00:33:50,560 --> 00:33:58,660
+موجودة في ال cell membrane تبع الخلية ماشي؟منها
+
+403
+00:33:58,660 --> 00:34:07,220
+الـ Acetylcholinesterase وهذا عبارة عن اكتشافه كان
+
+404
+00:34:07,220 --> 00:34:12,380
+صيحة اول اكتشاف اكتشفه انه فيه نقص في ال
+
+405
+00:34:12,380 --> 00:34:22,600
+Acetylcholinesterase عند ال RBC هذي و جالس عين
+
+406
+00:34:22,600 --> 00:34:28,180
+هذا عبارة عن انزين لجوا انه مش هو السببطب ها في
+
+407
+00:34:28,180 --> 00:34:31,340
+اشي تاني اقلجوا بروتينات تانية زي ال decay
+
+408
+00:34:31,340 --> 00:34:35,640
+accelerating factor هذا شو بيعمل قالوا هذا موجود
+
+409
+00:34:35,640 --> 00:34:39,780
+بشكل طبيعي على سطح كورة الدم الحمراء اول ما تتكون
+
+410
+00:34:39,780 --> 00:34:43,340
+ال C3BU هي عبارة عن complement active complement
+
+411
+00:34:43,340 --> 00:34:46,220
+component على سطح كورة الدم الحمراء بيعملها
+
+412
+00:34:46,220 --> 00:34:51,900
+blocking ووقفها واذا وقفها وقف كل ال cascade يعني
+
+413
+00:34:51,900 --> 00:34:57,960
+وقف نشاط ال complement غيابههو يسمح بنشاط الـ
+
+414
+00:34:57,960 --> 00:35:02,520
+complement للآخر ويكسّر كُعات الدم الحمراء نوع
+
+415
+00:35:02,520 --> 00:35:06,360
+التاني من البروتينات اللي هي برضه غالبا ميمبرين
+
+416
+00:35:06,360 --> 00:35:11,860
+انهيبتر و Reactive Lysis وهذا النوع لجوب يمنع
+
+417
+00:35:11,860 --> 00:35:16,320
+تكوين ال membrane attack complex وهو عبارة عن
+
+418
+00:35:16,320 --> 00:35:21,380
+جزئية تالتة في نشاط ال complement فإذا كان منع
+
+419
+00:35:21,380 --> 00:35:24,340
+تكوين اللي هو اللي بخرج ال RBCs اللي معملها
+
+420
+00:35:24,340 --> 00:35:27,540
+Hemolysisإذا كان عامل الهنهيشن معناته مافيش
+
+421
+00:35:27,540 --> 00:35:31,680
+Hemolysis الما التالت هو homologous restriction
+
+422
+00:35:31,680 --> 00:35:37,800
+factor another protein ياله بيمسك في C8 complement
+
+423
+00:35:37,800 --> 00:35:41,420
+رقم تمانية من ال cascade وبالتالي بيوقف ال
+
+424
+00:35:41,420 --> 00:35:44,720
+complement activation بروتينات موجودة بشكل طبيعي
+
+425
+00:35:44,720 --> 00:35:50,510
+بيسموها protective proteinsموجودين على كل normal
+
+426
+00:35:50,510 --> 00:35:54,170
+RBCs يوم ما تيجي ال compliment خطأ انت تتفاعل على
+
+427
+00:35:54,170 --> 00:36:00,630
+سطح كورعة الدم الحمراء ويقولونها no way في normal
+
+428
+00:36:00,630 --> 00:36:04,670
+circumstances في ايش normal circumstances لكن هذه
+
+429
+00:36:04,670 --> 00:36:08,070
+ال RBCs كنت لكم مخلقة ماعندهاش هذه ال proteinات
+
+430
+00:36:08,070 --> 00:36:11,090
+اللي هي ال protective protein وبالتالي التفاعلات
+
+431
+00:36:11,090 --> 00:36:14,730
+بتعيش بالتم على سطح كورعة الدم الحمراء وبتكسر
+
+432
+00:36:14,730 --> 00:36:18,980
+الكورات clinical pictureأتفقنا على أن يحصل فيه
+
+433
+00:36:18,980 --> 00:36:22,160
+Episodic نوبات of Intravascular Hemolysis
+
+434
+00:36:22,160 --> 00:36:29,760
+Hemoglobinuria Hemorrhage Infection Thrombotic
+
+435
+00:36:29,760 --> 00:36:34,540
+Complication والعوامل اللي بتؤدي .. Trigger the
+
+436
+00:36:34,540 --> 00:36:38,720
+Hemolysis mostly unknown السبب الأولاني أو
+
+437
+00:36:38,720 --> 00:36:43,560
+Infection أو ال Vaccination بيحفظ Antigen Antibody
+
+438
+00:36:43,560 --> 00:36:47,590
+Action وبينشر الكندرةو Blood Transfusion أيضا
+
+439
+00:36:47,590 --> 00:36:49,610
+عبارة عن Antigen Antibody Reaction بيحفج
+
+440
+00:36:49,610 --> 00:36:53,250
+complement و Infection محصلته Antigen Antibody
+
+441
+00:36:53,250 --> 00:36:57,890
+Reaction يبقى أي عامل ممكن يكوّن Antigen Antibody
+
+442
+00:36:57,890 --> 00:37:01,410
+Reaction هينشط ال complement لإنه شرط من شروط
+
+443
+00:37:01,410 --> 00:37:05,950
+تنشيط ال complement وجود هذا ال reaction Menstrual
+
+444
+00:37:05,950 --> 00:37:11,350
+cycle ما هو فيها فيها اللي هو tissue factor أيضا
+
+445
+00:37:11,350 --> 00:37:18,120
+ممكن تعملتنشيط للـ complement وتعمل جلطة cause of
+
+446
+00:37:18,120 --> 00:37:24,180
+death جابوا بموت المريض يعني نتيجة سبب من سببين
+
+447
+00:37:24,180 --> 00:37:28,000
+الأولاني infection شوان كان بكتيريا الولاة فانغل
+
+448
+00:37:28,000 --> 00:37:33,160
+infection لإن وجود ال infection بيعمل leukopenia
+
+449
+00:37:33,160 --> 00:37:38,040
+وبيعمل neutrophil dysfunction وهذا عبارة عن إيش
+
+450
+00:37:38,040 --> 00:37:43,970
+incompatible with life بعبادي للوفاةولكن السبب
+
+451
+00:37:43,970 --> 00:37:48,910
+الأساسي هو الـ venous thrombosis جلطة اللي بتسير
+
+452
+00:37:48,910 --> 00:37:54,470
+في الـ vein وفسروا جلطة بإنها هي بيسير في هذا
+
+453
+00:37:54,470 --> 00:37:57,330
+المرض release of a thromboplasty-like substance
+
+454
+00:37:57,330 --> 00:38:03,830
+يعني tissue factor اللي وجودها بيؤدي طبعا إلى جلطة
+
+455
+00:38:03,830 --> 00:38:08,010
+من وين جاي هذه المادة من كرات الدم الحمراء المكسرة
+
+456
+00:38:10,430 --> 00:38:15,210
+بهيك بنكون خلصنا المحاضرة و خلصنا الجزء الأول من
+
+457
+00:38:15,210 --> 00:38:25,910
+المادة وهو ال RBCs Production and RBCs Disorder
+
+458
+00:38:25,910 --> 00:38:30,570
+اللي هي الانيميا و أخدنا أنثى على أنواعها المختلفة
+
+459
+00:38:30,570 --> 00:38:37,570
+ماشي هناخد break الآنعلى بال ما ننتقل للجزء التاني
+
+460
+00:38:37,570 --> 00:38:41,250
+من المادة وهو white pieces and white pieces
+
+461
+00:38:41,250 --> 00:38:49,470
+disorder يعطيكوا
+
+462
+00:38:49,470 --> 00:38:49,990
+العافية
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..7abe0e75cd52de74132c2952951c07846527d522
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2711, "start": 1.47, "end": 27.11, "text": "بسم الله الرحمن الرحيم استكملا لمحاضرة الـ Hemolytic Anemia هنتطلق للـ Acquired Hemolytic Anemia الآن و الـ Acquired Hemolytic Anemia بمعنى أنه فيه ملزمنا Acquired Factor to induce Hemolysis قسموها إلى خمس أقسام يعني Hemolysis secondary to immune mechanism", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 44713, 24793, 15040, 32767, 5016, 46958, 25720, 2423, 39184, 18568, 16453, 40907, 1107, 14058, 8032, 29399, 9566, 1211, 4587, 24976, 39184, 5097, 358, 1824, 18568, 16453, 40907, 1107, 14058, 6024, 48506, 4032, 2423, 39184, 5097, 358, 1824, 18568, 16453, 40907, 1107, 14058, 4724, 2304, 3615, 1863, 7578, 14739, 3224, 8978, 3224, 3714, 1211, 11622, 2304, 8315, 5097, 358, 1824, 479, 15104, 281, 41263, 18568, 16453, 17122, 12174, 38251, 2407, 11296, 30731, 16490, 2304, 3794, 5551, 4587, 3794, 10943, 37495, 22653, 18568, 16453, 17122, 11396, 281, 11992, 7513], "avg_logprob": -0.25257732941932287, "compression_ratio": 1.6064814814814814, "no_speech_prob": 1.4901161193847656e-06, "words": [{"start": 1.47, "end": 1.73, "word": "بسم", "probability": 0.890869140625}, {"start": 1.73, "end": 1.97, "word": " الله", "probability": 0.95654296875}, {"start": 1.97, "end": 2.31, "word": " الرحمن", "probability": 0.9718424479166666}, {"start": 2.31, "end": 2.77, "word": " الرحيم", "probability": 0.9918619791666666}, {"start": 2.77, "end": 4.39, "word": " استكملا", "probability": 0.8098958333333334}, {"start": 4.39, "end": 5.05, "word": " لمحاضرة", "probability": 0.9559326171875}, {"start": 5.05, "end": 5.31, "word": " الـ", "probability": 0.5494384765625}, {"start": 5.31, "end": 5.75, "word": " Hemolytic", "probability": 0.7121175130208334}, {"start": 5.75, "end": 6.27, "word": " Anemia", "probability": 0.889404296875}, {"start": 6.27, "end": 9.05, "word": " هنتطلق", "probability": 0.662841796875}, {"start": 9.05, "end": 9.35, "word": " للـ", "probability": 0.640625}, 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{"start": 705.03, "end": 706.37, "word": " in", "probability": 0.1490478515625}, {"start": 706.37, "end": 707.03, "word": " the", "probability": 0.69384765625}, {"start": 707.03, "end": 707.83, "word": " complex", "probability": 0.6015625}, {"start": 707.83, "end": 710.01, "word": " وبالتالي", "probability": 0.92646484375}, {"start": 710.01, "end": 710.37, "word": " صارت", "probability": 0.9309895833333334}, {"start": 710.37, "end": 710.55, "word": " غير", "probability": 0.991943359375}, {"start": 710.55, "end": 711.13, "word": " طبيعية", "probability": 0.9793701171875}, {"start": 711.13, "end": 713.07, "word": " عشان", "probability": 0.93408203125}, {"start": 713.07, "end": 713.29, "word": " يصير", "probability": 0.5694986979166666}, {"start": 713.29, "end": 713.67, "word": " التفاعل", "probability": 0.9017333984375}, {"start": 713.67, "end": 713.89, "word": " هذا", "probability": 0.93994140625}, {"start": 713.89, "end": 714.05, "word": " it", "probability": 0.6884765625}, {"start": 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"word": " بيلاقي", "probability": 0.8389892578125}, {"start": 720.17, "end": 720.85, "word": " antibody", "probability": 0.80224609375}, {"start": 720.85, "end": 721.71, "word": " ال", "probability": 0.498046875}, {"start": 721.71, "end": 722.19, "word": " antibody", "probability": 0.71533203125}, {"start": 722.19, "end": 722.77, "word": " الجسم", "probability": 0.892333984375}, {"start": 722.77, "end": 723.23, "word": " بيعمل", "probability": 0.8961181640625}, {"start": 723.23, "end": 723.35, "word": " ال", "probability": 0.7802734375}, {"start": 723.35, "end": 723.57, "word": " drug", "probability": 0.97021484375}, {"start": 723.57, "end": 723.71, "word": " ك", "probability": 0.9814453125}, {"start": 723.71, "end": 724.33, "word": " antigen", "probability": 0.7607421875}], "temperature": 1.0}, {"id": 28, "seek": 74663, "start": 724.63, "end": 746.63, "text": "فبصير فيه Antibody reaction بيتكوّن immune complex بقعد على سطح كورات الدم الحمراء بتصير كورات الدم الحمراء هذه غير طبيعية فبصير عندنا احتمال من اتنين يا اما بيكون big reaction و بيكسر ال RBC ع المطرح Intravascular يا اما بكون التفاعل", "tokens": [5172, 3555, 9381, 13546, 8978, 3224, 5130, 897, 843, 5480, 4724, 36081, 4117, 2407, 11703, 1863, 11992, 3997, 4724, 4587, 22488, 15844, 8608, 9566, 5016, 9122, 13063, 9307, 32748, 2304, 21542, 29973, 16606, 39894, 9381, 13546, 9122, 13063, 9307, 32748, 2304, 21542, 29973, 16606, 29538, 32771, 13546, 23032, 21292, 3615, 10632, 6156, 3555, 9381, 13546, 43242, 8315, 1975, 33753, 2304, 6027, 9154, 1975, 2655, 1863, 9957, 35186, 1975, 15042, 4724, 1829, 30544, 955, 5480, 4032, 4724, 1829, 4117, 3794, 2288, 2423, 497, 7869, 6225, 9673, 9566, 2288, 5016, 5681, 13404, 22084, 35186, 1975, 15042, 4724, 30544, 16712, 5172, 995, 30241], "avg_logprob": -0.31265468880681707, "compression_ratio": 1.603448275862069, "no_speech_prob": 4.827976226806641e-06, "words": [{"start": 724.63, "end": 725.11, "word": "فبصير", "probability": 0.4596405029296875}, {"start": 725.11, "end": 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"word": " الحمراء", "probability": 0.7491861979166666}, {"start": 750.32, "end": 750.84, "word": " تتعرف", "probability": 0.846435546875}, {"start": 750.84, "end": 751.2, "word": " عليها", "probability": 0.994140625}, {"start": 751.2, "end": 751.32, "word": " الـ", "probability": 0.638916015625}, {"start": 751.32, "end": 751.64, "word": " reticulum", "probability": 0.4573160807291667}, {"start": 751.64, "end": 752.14, "word": " endothelial", "probability": 0.8834228515625}, {"start": 752.14, "end": 752.64, "word": " system", "probability": 0.94580078125}, {"start": 752.64, "end": 753.9, "word": " وتكسّرها", "probability": 0.85546875}, {"start": 753.9, "end": 755.12, "word": " Extravascular", "probability": 0.6742350260416666}, {"start": 755.12, "end": 755.92, "word": " التفاعل", "probability": 0.80963134765625}, {"start": 755.92, "end": 756.3, "word": " بيصير", "probability": 0.6890869140625}, {"start": 756.3, "end": 756.62, "word": " إما", "probability": 0.896728515625}, {"start": 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فعشان يصير في immune reaction يعني antigen، antibody reaction بروح و مكبر حاله، إيش بيعمل؟ باتبع ال drug اللي دخل، يبقى في عندنا في الأساس عندنا protein", "tokens": [3224, 2407, 6225, 3555, 9640, 3660, 18871, 14739, 2655, 7435, 1863, 20328, 17082, 13546, 20193, 7251, 14851, 9566, 40228, 2423, 37405, 295, 11992, 3997, 11992, 5480, 6156, 3615, 8592, 7649, 7251, 9381, 13546, 8978, 11992, 5480, 37495, 22653, 2511, 3213, 12399, 34507, 5480, 4724, 32887, 5016, 4032, 3714, 4117, 26890, 11331, 6027, 3224, 12399, 11933, 1829, 8592, 4724, 1829, 25957, 1211, 22807, 4724, 9307, 3555, 3615, 2423, 4110, 13672, 1829, 11778, 9778, 1211, 12399, 7251, 3555, 4587, 7578, 8978, 43242, 8315, 8978, 16247, 3794, 32277, 43242, 8315, 7944], "avg_logprob": -0.2689606607630012, "compression_ratio": 1.5315315315315314, "no_speech_prob": 0.0, "words": [{"start": 775.81, "end": 776.17, "word": "هو", "probability": 0.91015625}, {"start": 776.17, "end": 776.51, "word": " عبارة", "probability": 0.9757080078125}, 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"word": " donor", "probability": 0.84228515625}, {"start": 1215.01, "end": 1215.71, "word": " and", "probability": 0.92236328125}, {"start": 1215.71, "end": 1216.23, "word": " recipient", "probability": 0.83154296875}, {"start": 1216.23, "end": 1217.33, "word": " مستقبل", "probability": 0.9559326171875}, {"start": 1217.33, "end": 1217.95, "word": " والإياج", "probability": 0.6365966796875}, {"start": 1217.95, "end": 1220.09, "word": " والمتبرئ", "probability": 0.79453125}], "temperature": 1.0}, {"id": 46, "seek": 122980, "start": 1221.9, "end": 1229.8, "text": "و يتدور على فتنين تعمل antibody screening تدور على antibody for both", "tokens": [2407, 7251, 2655, 3215, 13063, 15844, 6156, 2655, 1863, 9957, 6055, 25957, 1211, 34507, 17732, 6055, 3215, 13063, 15844, 34507, 337, 1293], "avg_logprob": -0.372961964296258, "compression_ratio": 1.1481481481481481, "no_speech_prob": 0.0, "words": [{"start": 1221.9, "end": 1222.14, "word": "و", "probability": 0.45458984375}, {"start": 1222.14, 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{"start": 1313.51, "end": 1315.21, "word": " فشو", "probability": 0.9864908854166666}, {"start": 1315.21, "end": 1315.29, "word": " اللي", "probability": 0.992919921875}, {"start": 1315.29, "end": 1315.73, "word": " بصير", "probability": 0.9871419270833334}, {"start": 1315.73, "end": 1315.93, "word": " اللي", "probability": 0.9013671875}, {"start": 1315.93, "end": 1316.31, "word": " بصير", "probability": 0.9933268229166666}, {"start": 1316.31, "end": 1316.95, "word": " انه", "probability": 0.8583984375}, {"start": 1316.95, "end": 1318.47, "word": " عند", "probability": 0.99072265625}, {"start": 1318.47, "end": 1318.99, "word": " ولادة", "probability": 0.844970703125}], "temperature": 1.0}, {"id": 50, "seek": 133927, "start": 1320.21, "end": 1339.27, "text": "و عند قطع الحبل السريري تدخل شوية RBCs من البيولي عالمين على دم الأم فبيبدأ الجسم يكوّن لها antibody وما أن ال RH مثالنا على ال RH قلنا ان ال antibody تبع ال RH من نوع IGG", "tokens": [2407, 43242, 12174, 9566, 3615, 21542, 36150, 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{"start": 1337.13, "end": 1337.13, "word": " ال", "probability": 0.798828125}, {"start": 1337.13, "end": 1337.55, "word": " antibody", "probability": 0.8125}, {"start": 1337.55, "end": 1337.85, "word": " تبع", "probability": 0.72802734375}, {"start": 1337.85, "end": 1337.97, "word": " ال", "probability": 0.970703125}, {"start": 1337.97, "end": 1338.27, "word": " RH", "probability": 0.83740234375}, {"start": 1338.27, "end": 1338.45, "word": " من", "probability": 0.89208984375}, {"start": 1338.45, "end": 1338.61, "word": " نوع", "probability": 0.652587890625}, {"start": 1338.61, "end": 1339.27, "word": " IGG", "probability": 0.7178955078125}], "temperature": 1.0}, {"id": 51, "seek": 136885, "start": 1340.45, "end": 1368.85, "text": "فبدّى عند الأم في دمها تواجد الـ Antibody اللى هو تبع الـ Rh و اللى هو منه IGG فى الحمض التانى أو ممكن اللى بعده أو اللى بعده ماشي فى الحمض التانى إذا اختلف إذا إجا الجمين برضه مختلف عن الأم ال Antibody اللى اتكونت للـ Rh بإيكروكاميكروستابلاسينتا", "tokens": 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"start": 1369.51, "end": 1395.21, "text": "وبتدخل على ال baby التاني وبتغطله لأنه بيصير فيه Antibody reaction وHemolysis لل RBCs of the baby والمحصلة يعني death العملية زي ما اتفقنا it requires maternal IgG لازم يخش versus antigen in the fetus وزي ما انتوا شايفين بيصير حاجة بيسموها erythroplastosis fetalis", "tokens": [37746, 2655, 3215, 9778, 1211, 15844, 2423, 3186, 16712, 7649, 1829, 46599, 2655, 17082, 9566, 43761, 5296, 33456, 3224, 4724, 1829, 9381, 13546, 8978, 3224, 5130, 897, 843, 5480, 4032, 39, 443, 16453, 17122, 24976, 497, 7869, 82, 295, 264, 3186, 4032, 45340, 5016, 9381, 37977, 37495, 22653, 2966, 18863, 42213, 10632, 30767, 1829, 19446, 1975, 2655, 5172, 4587, 8315, 309, 7029, 37944, 19271, 38, 5296, 31377, 2304, 7251, 9778, 8592, 5717, 2511, 3213, 294, 264, 15136, 301, 4032, 11622, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 4724, 1829, 9381, 13546, 11331, 26108, 3660, 4724, 1829, 38251, 2407, 11296, 1189, 88, 392, 340, 564, 525, 8211, 15136, 48581], 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{"start": 1384.47, "end": 1384.59, "word": " ما", "probability": 0.8125}, {"start": 1384.59, "end": 1385.05, "word": " اتفقنا", "probability": 0.964453125}, {"start": 1385.05, "end": 1385.25, "word": " it", "probability": 0.439453125}, {"start": 1385.25, "end": 1385.71, "word": " requires", "probability": 0.83056640625}, {"start": 1385.71, "end": 1386.25, "word": " maternal", "probability": 0.3486328125}, {"start": 1386.25, "end": 1386.95, "word": " IgG", "probability": 0.917724609375}, {"start": 1386.95, "end": 1387.31, "word": " لازم", "probability": 0.9431966145833334}, {"start": 1387.31, "end": 1387.73, "word": " يخش", "probability": 0.92822265625}, {"start": 1387.73, "end": 1389.03, "word": " versus", "probability": 0.802734375}, {"start": 1389.03, "end": 1389.89, "word": " antigen", "probability": 0.82080078125}, {"start": 1389.89, "end": 1390.11, "word": " in", "probability": 0.955078125}, {"start": 1390.11, "end": 1390.25, "word": " the", "probability": 0.92919921875}, 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"end": 1646.34, "text": "اللي هو الـSteroid اللي هو Immune Suppressant Drug أو إنه نشيل الـSpleen لأن الـSpleen اللي بيصير فيه تكسير الـCold Type mostly الـAntibody هو IgM برتبط في درجات حرارة متدنية لأن اسمه Cold Type يعني في تلاتين وأقل ويستطيع أن يرتبط أو ينشط الـComplement كاملاً", "tokens": [6027, 20292, 31439, 2423, 39184, 4520, 2032, 327, 13672, 1829, 31439, 17322, 2613, 9391, 735, 394, 35806, 34051, 36145, 3224, 8717, 8592, 26895, 2423, 39184, 50, 781, 268, 5296, 33456, 2423, 39184, 50, 781, 268, 13672, 1829, 4724, 1829, 9381, 13546, 8978, 3224, 6055, 4117, 3794, 13546, 2423, 39184, 34, 2641, 15576, 5240, 2423, 39184, 35807, 897, 843, 31439, 19271, 44, 4724, 43500, 3555, 9566, 8978, 11778, 47341, 9307, 11331, 2288, 9640, 3660, 44650, 3215, 1863, 10632, 5296, 33456, 24525, 2304, 3224, 16918, 15576, 37495, 22653, 8978, 6055, 1211, 9307, 9957, 36725, 4587, 1211, 4032, 1829, 14851, 9566, 40228, 14739, 7251, 43500, 3555, 9566, 34051, 7251, 1863, 8592, 9566, 2423, 39184, 14627, 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"text": "ما بتتنشط إلا في وجود Antigen أو Antigen Antibody reaction ماشي لكن لو وجدت تتنشط في الوضع الطبيعي على سطح كورات دم حمراء تغري كورات الدم الحمراء تملع نشاطها في الوضع الطبيعي لكن في هذا النوع من المرض بتتخلق ال RBC من البنمرو فيها عيب ايش العيب قالوا انه والله", "tokens": [15042, 39894, 2655, 1863, 8592, 9566, 11933, 15040, 8978, 49610, 23328, 5130, 3213, 34051, 5130, 3213, 5130, 897, 843, 5480, 3714, 33599, 1829, 44381, 45164, 49610, 3215, 2655, 6055, 2655, 1863, 8592, 9566, 8978, 2423, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 15844, 8608, 9566, 5016, 9122, 13063, 9307, 11778, 2304, 11331, 29973, 16606, 6055, 17082, 16572, 9122, 13063, 9307, 32748, 2304, 21542, 29973, 16606, 46811, 1211, 3615, 8717, 8592, 41193, 11296, 8978, 2423, 2407, 11242, 3615, 41950, 21292, 3615, 1829, 44381, 8978, 23758, 28239, 45367, 9154, 9673, 43042, 39894, 2655, 9778, 1211, 4587, 2423, 497, 7869, 9154, 29739, 1863, 29973, 2407, 8978, 11296, 6225, 1829, 3555, 1975, 1829, 8592, 18863, 1829, 3555, 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{"start": 2119.04, "end": 2119.22, "word": " ال", "probability": 0.9716796875}, {"start": 2119.22, "end": 2119.64, "word": " complement", "probability": 0.5537109375}, {"start": 2119.64, "end": 2120.92, "word": " فإذا", "probability": 0.9332682291666666}, {"start": 2120.92, "end": 2121.16, "word": " كان", "probability": 0.98974609375}, {"start": 2121.16, "end": 2121.38, "word": " منع", "probability": 0.750732421875}, {"start": 2121.38, "end": 2121.84, "word": " تكوين", "probability": 0.9564208984375}, {"start": 2121.84, "end": 2122.04, "word": " اللي", "probability": 0.900390625}, {"start": 2122.04, "end": 2122.28, "word": " هو", "probability": 0.63671875}, {"start": 2122.28, "end": 2122.4, "word": " اللي", "probability": 0.831787109375}, {"start": 2122.4, "end": 2122.76, "word": " بخرج", "probability": 0.7623697916666666}, {"start": 2122.76, "end": 2122.9, "word": " ال", "probability": 0.9013671875}, {"start": 2122.9, "end": 2123.62, "word": " RBCs", "probability": 0.549072265625}, {"start": 2123.62, "end": 2123.8, "word": " اللي", "probability": 0.914794921875}, {"start": 2123.8, "end": 2124.34, "word": " معملها", "probability": 0.83734130859375}, {"start": 2124.34, "end": 2124.84, "word": " Hemolysis", "probability": 0.7194010416666666}], "temperature": 1.0}, {"id": 79, "seek": 214730, "start": 2125.32, "end": 2147.3, "text": "إذا كان عامل الهنهيشن معناته مافيش Hemolysis الما التالت هو homologous restriction factor another protein ياله بيمسك في C8 complement رقم تمانية من ال cascade وبالتالي بيوقف ال complement activation بروتينات موجودة بشكل طبيعي بيسموها protective proteins", "tokens": [28814, 15730, 25961, 6225, 10943, 1211, 2423, 3224, 1863, 3224, 1829, 8592, 1863, 20449, 8315, 47395, 19446, 41185, 8592, 18568, 401, 4642, 2423, 15042, 16712, 6027, 2655, 31439, 3655, 1132, 563, 29529, 5952, 1071, 7944, 7251, 6027, 3224, 4724, 32640, 3794, 4117, 8978, 383, 23, 17103, 12602, 4587, 2304, 46811, 7649, 10632, 9154, 2423, 50080, 46599, 6027, 2655, 6027, 1829, 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"end": 2258.04, "word": " إيش", "probability": 0.5608723958333334}, {"start": 2258.04, "end": 2259.96, "word": " incompatible", "probability": 0.7377115885416666}, {"start": 2259.96, "end": 2260.16, "word": " with", "probability": 0.927734375}, {"start": 2260.16, "end": 2260.48, "word": " life", "probability": 0.95947265625}, {"start": 2260.48, "end": 2261.14, "word": " بعبادي", "probability": 0.68328857421875}, {"start": 2261.14, "end": 2261.84, "word": " للوفاة", "probability": 0.92822265625}], "temperature": 1.0}, {"id": 84, "seek": 228801, "start": 2262.63, "end": 2288.01, "text": "ولكن السبب الأساسي هو الـ venous thrombosis جلطة اللي بتسير في الـ vein وفسروا جلطة بإنها هي بيسير في هذا المرض release of a thromboplasty-like substance يعني tissue factor اللي وجودها بيؤدي طبعا إلى جلطة من وين جاي هذه المادة من كرات الدم الحمراء المكسرة", "tokens": [12610, 19452, 21136, 3555, 3555, 16247, 3794, 32277, 1829, 31439, 2423, 39184, 6138, 563, 739, 3548, 8211, 10874, 1211, 9566, 3660, 13672, 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2265.95, "end": 2266.89, "word": " الـ", "probability": 0.597900390625}, {"start": 2266.89, "end": 2267.25, "word": " venous", "probability": 0.58013916015625}, {"start": 2267.25, "end": 2267.99, "word": " thrombosis", "probability": 0.9728190104166666}, {"start": 2267.99, "end": 2268.47, "word": " جلطة", "probability": 0.7923583984375}, {"start": 2268.47, "end": 2268.59, "word": " اللي", "probability": 0.459228515625}, {"start": 2268.59, "end": 2268.91, "word": " بتسير", "probability": 0.6836751302083334}, {"start": 2268.91, "end": 2269.07, "word": " في", "probability": 0.81689453125}, {"start": 2269.07, "end": 2269.17, "word": " الـ", "probability": 0.6114501953125}, {"start": 2269.17, "end": 2269.47, "word": " vein", "probability": 0.736328125}, {"start": 2269.47, "end": 2270.91, "word": " وفسروا", "probability": 0.7794189453125}, {"start": 2270.91, "end": 2271.69, "word": " جلطة", "probability": 0.899169921875}, {"start": 2271.69, "end": 2272.53, "word": " بإنها", "probability": 0.8604736328125}, {"start": 2272.53, "end": 2272.91, "word": " هي", "probability": 0.62158203125}, {"start": 2272.91, "end": 2273.95, "word": " بيسير", "probability": 0.7689208984375}, {"start": 2273.95, "end": 2274.15, "word": " في", "probability": 0.94287109375}, {"start": 2274.15, "end": 2274.47, "word": " هذا", "probability": 0.79345703125}, {"start": 2274.47, "end": 2274.89, "word": " المرض", "probability": 0.9892578125}, {"start": 2274.89, "end": 2275.37, "word": " release", "probability": 0.483642578125}, {"start": 2275.37, "end": 2275.59, "word": " of", "probability": 0.9326171875}, {"start": 2275.59, "end": 2275.71, "word": " a", "probability": 0.361572265625}, {"start": 2275.71, "end": 2276.45, "word": " thromboplasty", "probability": 0.732177734375}, {"start": 2276.45, "end": 2276.73, "word": "-like", "probability": 0.6488037109375}, {"start": 2276.73, "end": 2277.33, "word": " substance", "probability": 0.97216796875}, {"start": 2277.33, "end": 2277.95, "word": " يعني", "probability": 0.83154296875}, {"start": 2277.95, "end": 2278.25, "word": " tissue", "probability": 0.389892578125}, {"start": 2278.25, "end": 2278.89, "word": " factor", "probability": 0.87060546875}, {"start": 2278.89, "end": 2279.79, "word": " اللي", "probability": 0.89013671875}, {"start": 2279.79, "end": 2280.91, "word": " وجودها", "probability": 0.9729817708333334}, {"start": 2280.91, "end": 2281.61, "word": " بيؤدي", "probability": 0.8927001953125}, {"start": 2281.61, "end": 2283.07, "word": " طبعا", "probability": 0.9486083984375}, {"start": 2283.07, "end": 2283.25, "word": " إلى", "probability": 0.8359375}, {"start": 2283.25, "end": 2283.83, "word": " جلطة", "probability": 0.98974609375}, {"start": 2283.83, "end": 2284.03, "word": " من", "probability": 0.81591796875}, {"start": 2284.03, "end": 2284.23, "word": " وين", "probability": 0.901611328125}, {"start": 2284.23, "end": 2284.59, "word": " جاي", "probability": 0.829345703125}, {"start": 2284.59, "end": 2285.21, "word": " هذه", "probability": 0.92431640625}, {"start": 2285.21, "end": 2285.67, "word": " المادة", "probability": 0.9915364583333334}, {"start": 2285.67, "end": 2285.89, "word": " من", "probability": 0.984375}, {"start": 2285.89, "end": 2286.25, "word": " كرات", "probability": 0.612060546875}, {"start": 2286.25, "end": 2286.53, "word": " الدم", "probability": 0.972412109375}, {"start": 2286.53, "end": 2287.15, "word": " الحمراء", "probability": 0.8583984375}, {"start": 2287.15, "end": 2288.01, "word": " المكسرة", "probability": 0.98779296875}], "temperature": 1.0}, {"id": 85, "seek": 231413, "start": 2290.43, "end": 2314.13, "text": "بهيك بنكون خلصنا المحاضرة و خلصنا الجزء الأول من المادة وهو ال RBCs Production and RBCs Disorder اللي هي الانيميا و أخدنا أنثى على أنواعها المختلفة ماشي هناخد break الآن", "tokens": [3555, 3224, 1829, 4117, 44945, 30544, 16490, 1211, 9381, 8315, 9673, 5016, 46958, 25720, 4032, 16490, 1211, 9381, 8315, 25724, 11622, 38207, 16247, 12610, 9154, 9673, 18513, 3660, 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0.9161783854166666}, {"start": 2294.39, "end": 2294.95, "word": " الأول", "probability": 0.804443359375}, {"start": 2294.95, "end": 2295.21, "word": " من", "probability": 0.984375}, {"start": 2295.21, "end": 2296.39, "word": " المادة", "probability": 0.9869791666666666}, {"start": 2296.39, "end": 2297.87, "word": " وهو", "probability": 0.85205078125}, {"start": 2297.87, "end": 2298.29, "word": " ال", "probability": 0.837890625}, {"start": 2298.29, "end": 2299.67, "word": " RBCs", "probability": 0.6749674479166666}, {"start": 2299.67, "end": 2301.19, "word": " Production", "probability": 0.55224609375}, {"start": 2301.19, "end": 2303.01, "word": " and", "probability": 0.634765625}, {"start": 2303.01, "end": 2304.29, "word": " RBCs", "probability": 0.8914388020833334}, {"start": 2304.29, "end": 2305.91, "word": " Disorder", "probability": 0.9609375}, {"start": 2305.91, "end": 2306.15, "word": " اللي", "probability": 0.8544921875}, {"start": 2306.15, "end": 2306.29, "word": " هي", "probability": 0.77734375}, {"start": 2306.29, "end": 2307.03, "word": " الانيميا", "probability": 0.69439697265625}, {"start": 2307.03, "end": 2307.73, "word": " و", "probability": 0.4833984375}, {"start": 2307.73, "end": 2308.19, "word": " أخدنا", "probability": 0.9449462890625}, {"start": 2308.19, "end": 2308.67, "word": " أنثى", "probability": 0.8611653645833334}, {"start": 2308.67, "end": 2308.89, "word": " على", "probability": 0.9169921875}, {"start": 2308.89, "end": 2309.57, "word": " أنواعها", "probability": 0.96826171875}, {"start": 2309.57, "end": 2310.57, "word": " المختلفة", "probability": 0.994873046875}, {"start": 2310.57, "end": 2311.81, "word": " ماشي", "probability": 0.845703125}, {"start": 2311.81, "end": 2312.39, "word": " هناخد", "probability": 0.857421875}, {"start": 2312.39, "end": 2313.63, "word": " break", "probability": 0.96630859375}, {"start": 2313.63, "end": 2314.13, "word": " الآن", "probability": 0.662109375}], "temperature": 1.0}, {"id": 86, "seek": 232998, "start": 2314.93, "end": 2329.99, "text": "على بال ما ننتقل للجزء التاني من المادة وهو white pieces and white pieces disorder يعطيكوا العافية", "tokens": [3615, 23942, 20666, 19446, 8717, 29399, 4587, 1211, 24976, 7435, 11622, 38207, 16712, 7649, 1829, 9154, 9673, 18513, 3660, 37037, 2407, 2418, 3755, 293, 2418, 3755, 13399, 37495, 9566, 1829, 4117, 14407, 18863, 31845, 10632], "avg_logprob": -0.3200954819718997, "compression_ratio": 1.2564102564102564, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 2314.93, "end": 2315.25, "word": "على", "probability": 0.5126953125}, {"start": 2315.25, "end": 2315.47, "word": " بال", "probability": 0.716796875}, {"start": 2315.47, "end": 2315.61, "word": " ما", "probability": 0.2200927734375}, {"start": 2315.61, "end": 2316.23, "word": " ننتقل", "probability": 0.8448486328125}, {"start": 2316.23, "end": 2317.11, "word": " للجزء", "probability": 0.8392333984375}, {"start": 2317.11, "end": 2317.57, "word": " التاني", "probability": 0.8935546875}, {"start": 2317.57, "end": 2317.73, "word": " من", "probability": 0.57958984375}, {"start": 2317.73, "end": 2318.25, "word": " المادة", "probability": 0.958984375}, {"start": 2318.25, "end": 2318.79, "word": " وهو", "probability": 0.8388671875}, {"start": 2318.79, "end": 2319.19, "word": " white", "probability": 0.54248046875}, {"start": 2319.19, "end": 2319.71, "word": " pieces", "probability": 0.33984375}, {"start": 2319.71, "end": 2320.47, "word": " and", "probability": 0.5478515625}, {"start": 2320.47, "end": 2320.73, "word": " white", "probability": 0.8505859375}, {"start": 2320.73, "end": 2321.25, "word": " pieces", "probability": 0.87109375}, {"start": 2321.25, "end": 2322.33, "word": " disorder", "probability": 0.80908203125}, {"start": 2322.33, "end": 2329.47, "word": " يعطيكوا", "probability": 0.763916015625}, {"start": 2329.47, "end": 2329.99, "word": " العافية", "probability": 0.82373046875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2330.8190625, "duration_after_vad": 2253.1218749999916}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..93fa09e0483537a9fe748bdff52d3ab9291d8db8
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/acvRyWcp0Qc_raw.srt
@@ -0,0 +1,1848 @@
+1
+00:00:01,470 --> 00:00:05,310
+بسم الله الرحمن الرحيم استكملا لمحاضرة الـ
+
+2
+00:00:05,310 --> 00:00:10,210
+Hemolytic Anemia هنتطلق للـ Acquired Hemolytic
+
+3
+00:00:10,210 --> 00:00:15,690
+Anemia الآن و الـ Acquired Hemolytic Anemia بمعنى
+
+4
+00:00:15,690 --> 00:00:21,170
+أنه فيه ملزمنا Acquired Factor to induce Hemolysis
+
+5
+00:00:21,170 --> 00:00:26,090
+قسموها إلى خمس أقسام يعني Hemolysis secondary to
+
+6
+00:00:26,090 --> 00:00:30,120
+immune mechanismيعني في تفاعل antigen-antibody
+
+7
+00:00:30,120 --> 00:00:34,900
+reaction secondary to action of chemical drugs or
+
+8
+00:00:34,900 --> 00:00:38,840
+toxin دخل chemical أو drug أو toxin secondary to
+
+9
+00:00:38,840 --> 00:00:42,340
+infection صار hemolysis due to infection or
+
+10
+00:00:42,340 --> 00:00:46,700
+secondary to physical damage ضربة or trauma and
+
+11
+00:00:46,700 --> 00:00:51,420
+miscellaneous بمعنى متفرقات برضه اندرجت تحت هذا
+
+12
+00:00:51,420 --> 00:00:55,640
+الموضوع ال immune hemolytic anemia من الإسم هي
+
+13
+00:00:55,640 --> 00:00:59,330
+عبارة عن تفاعل antigen مع antibodyلما بقول immune
+
+14
+00:00:59,330 --> 00:01:03,290
+يعني إيش؟ antigen antibody reaction and this
+
+15
+00:01:03,290 --> 00:01:08,850
+reaction بيعتمد على العوامل الآتية يعني ما يؤثر في
+
+16
+00:01:08,850 --> 00:01:16,370
+هذا التفاعل العوامل الآتية قالوا ال .. نمر واحد
+
+17
+00:01:16,370 --> 00:01:18,970
+class of antibody، شو يعني class؟ يعني نوع ال
+
+18
+00:01:18,970 --> 00:01:20,110
+antibody اللي موجود
+
+19
+00:01:27,140 --> 00:01:31,680
+في عملية ال activation أو ال reaction اللي بدأ
+
+20
+00:01:31,680 --> 00:01:36,860
+يحصل نمرا اتنين number and spacing of antigenic
+
+21
+00:01:36,860 --> 00:01:41,420
+site يعني عدد والمسافة اللي موجودة ما بين ال
+
+22
+00:01:41,420 --> 00:01:43,620
+antigenic site ال antigenic site الموجود فيها ال
+
+23
+00:01:43,620 --> 00:01:48,240
+ab-tops يعني ال antigen المناطق ارتباط ال antigen
+
+24
+00:01:48,240 --> 00:01:53,500
+بال antibody عشان على سطح القضية لكل ما زادت
+
+25
+00:01:53,500 --> 00:02:02,490
+المسافة بين الرواقEpitopes كل ما احتجنا لانتيبادي
+
+26
+00:02:02,490 --> 00:02:09,070
+كبير اي ال IGM عشاناش يتفاعل معاه كل ما قلت
+
+27
+00:02:09,070 --> 00:02:16,130
+المسافة طبعا هذا بيعتمد على العدد كل ما كان ال
+
+28
+00:02:16,130 --> 00:02:21,550
+antibody حتى وكان صغير monomeric يعني ممكن ينشر أو
+
+29
+00:02:21,550 --> 00:02:23,810
+يكسر ال news in monocyte
+
+30
+00:02:57,740 --> 00:03:02,270
+مش بس أنا ناسي الميكروفونإن شاء الله هالجيتر يكون
+
+31
+00:03:02,270 --> 00:03:08,330
+الوضع أحسن يبقى التفاعل بيعتمد على العوامل القاتية
+
+32
+00:03:08,330 --> 00:03:15,450
+نمرا واحد اللي هو ال class of antibody نمرا
+
+33
+00:03:15,450 --> 00:03:19,950
+اتنين يعني ان هو ال antibody هل هو IGM ولا IGG
+
+34
+00:03:19,950 --> 00:03:24,630
+نمرا اتنين ال number هو and spacing of antigenic
+
+35
+00:03:24,630 --> 00:03:30,590
+sites يعني العددوعدد الـ Epitopes والمسافة
+
+36
+00:03:30,590 --> 00:03:33,970
+الموجودة بين الـ Epitopes الـ Epitopes هو عبارة عن
+
+37
+00:03:33,970 --> 00:03:39,170
+مناطق ارتباط الـ Antibody بالـ Antigen ماشي فكل ما
+
+38
+00:03:39,170 --> 00:03:43,550
+كانت ال Epitopes متباعدة كل ما احتجنا ل Antibody
+
+39
+00:03:43,550 --> 00:03:47,610
+كبير عشان يتفاعل معاه وكل ما كانت متقاربة كل ما
+
+40
+00:03:47,610 --> 00:03:52,830
+كان زي ال IGMكل ما كانت متقاربة ال IGG لحد ممكن يش
+
+41
+00:03:52,830 --> 00:03:56,670
+اللي هو ال monomeric antibody ممكن يش يكسر اللي هي
+
+42
+00:03:56,670 --> 00:04:02,190
+ادنوية ال compliment ال compliment لها receptor
+
+43
+00:04:02,190 --> 00:04:10,890
+على سطح خلايا كثيرة فوجود ال antibody وجود ال
+
+44
+00:04:10,890 --> 00:04:13,470
+compliment على سطح خلايا الدم الحمراء كفيل بأنه
+
+45
+00:04:13,470 --> 00:04:20,050
+نشط ال complimentأو في الوسط يعني عفوا وجود
+
+46
+00:04:20,050 --> 00:04:22,810
+الانتيجن antibody reaction هو وجود ال complement
+
+47
+00:04:22,810 --> 00:04:25,850
+في الوسط بنفس ال complement و ال complement كفيلة
+
+48
+00:04:25,850 --> 00:04:30,250
+منها تكسر قلعة الدم الحمراء العامل الرابع ال
+
+49
+00:04:30,250 --> 00:04:32,870
+temperature ال temperature تلعب دور كبير في سرعة
+
+50
+00:04:32,870 --> 00:04:39,410
+التفاعل ثم ال efficiency of reticulum in the cell
+
+51
+00:04:39,410 --> 00:04:43,630
+system شغال ميح ولا لأ اللي هوالـ Spleen أو ما
+
+52
+00:04:43,630 --> 00:04:48,390
+يُعرف بالـ reticulum endothelial system Spleen and
+
+53
+00:04:48,390 --> 00:04:53,550
+liver طيب مانفستيشن كيف بنشوف التفاعل؟ جاله تفاعل
+
+54
+00:04:53,550 --> 00:04:59,530
+محصلة وإما Intravascular Hemorrhage وإما
+
+55
+00:04:59,530 --> 00:05:02,290
+Extravascular Hemorrhage واحنا عرفنا ال
+
+56
+00:05:02,290 --> 00:05:05,430
+Intravascular يعني بيصير تكسير في داخل الوعي دموعي
+
+57
+00:05:05,430 --> 00:05:10,110
+و Extravascular بيصير في secondary lymphoid or
+
+58
+00:05:10,110 --> 00:05:15,310
+reticulum endothelial systemالقاعدة ناخدها في ان
+
+59
+00:05:15,310 --> 00:05:18,850
+اعتبار يما ال antibody ترتبط بال RBCs يعني تجد على
+
+60
+00:05:18,850 --> 00:05:24,490
+سطح ال RBCs لأن ال RBCs على سطحها Antigen فإذا ال
+
+61
+00:05:24,490 --> 00:05:28,210
+antibody مسيك في ال Antigen على سطح كورات الدم
+
+62
+00:05:28,210 --> 00:05:33,610
+الحمراء هيكون في احتمال من اتنين اما هذا التفاعل
+
+63
+00:05:33,610 --> 00:05:38,930
+ينشط ال complement cascade للاخر ومحصلة تكسير
+
+64
+00:05:38,930 --> 00:05:44,470
+كورات الدم الحمراءوإما ان انت بدي بيكون صغير فبيجي
+
+65
+00:05:44,470 --> 00:05:51,670
+بقعد على سطح ال RBCs بس مابيكسرها طب شو بيعمل
+
+66
+00:05:51,670 --> 00:05:56,450
+فيها؟ قالوا بيعلمها لمين؟للـ macrophage اللي في
+
+67
+00:05:56,450 --> 00:05:59,270
+الـ reticular endothelial system فأول ما تصل ..
+
+68
+00:05:59,270 --> 00:06:01,850
+يعني الـ spleen احنا دايما بضرب مثال على ال spleen
+
+69
+00:06:01,850 --> 00:06:06,550
+أول ما تصل ال RBCs لل spleen تتعرف عليه ال
+
+70
+00:06:06,550 --> 00:06:14,870
+macrophage ك abnormal cell و بيكسرها أول بأولطبعاً
+
+71
+00:06:14,870 --> 00:06:18,490
+زي ما اتفقنا إذا كان الاحتمال الأول هو اللي صار
+
+72
+00:06:18,490 --> 00:06:21,790
+بده يصير فيه Intravascular Hemolysis وإذا الاحتمال
+
+73
+00:06:21,790 --> 00:06:25,590
+التاني هو اللي صار بده يصير فيه Extravascular
+
+74
+00:06:25,590 --> 00:06:32,590
+Hemolysis في الخلية. كده لما نخش في ال union
+
+75
+00:06:32,590 --> 00:06:37,170
+Hemolytic Anemia بأنواعها قدوا وقالوا ضروري نتعرف
+
+76
+00:06:37,170 --> 00:06:44,550
+على فحص اسمه Coombs Testوالـ Combs Test هذا فحص
+
+77
+00:06:44,550 --> 00:06:49,530
+نتعرف من خلاله على أو نشخص من خلاله الـ Immune
+
+78
+00:06:49,530 --> 00:06:54,610
+Hemolytic Anemia جابوا و ال Combs Test هو عبارة عن
+
+79
+00:06:54,610 --> 00:06:59,810
+نوعين إما direct و إما indirect فال direct بيدور
+
+80
+00:06:59,810 --> 00:07:03,130
+على immunoglobulin أو complement على سطح كورة الدم
+
+81
+00:07:03,130 --> 00:07:08,230
+الحمراءفي الوضع الطبيعي هذه لا ال antibody ولا ال
+
+82
+00:07:08,230 --> 00:07:15,190
+complement موجود على سطح كولات الدم الحمراء وإذا
+
+83
+00:07:15,190 --> 00:07:17,730
+مولد بالفعل مع ال compulsive agent ال compulsive
+
+84
+00:07:17,730 --> 00:07:21,470
+agent هو عبارة عن خليط من Anti human
+
+85
+00:07:21,470 --> 00:07:26,710
+immunoglobulin يعني Anti antibody و Anti human
+
+86
+00:07:26,710 --> 00:07:31,210
+complement يعني Anti complement فشوية كانت ال
+
+87
+00:07:31,210 --> 00:07:33,970
+immunoglobulin او ال complement بعد على سطح كولات
+
+88
+00:07:33,970 --> 00:07:37,770
+الدم الحمراءلو ضفنا الـ Constant agent هيتفاعل
+
+89
+00:07:37,770 --> 00:07:43,010
+معايدنا agglutination للاربيسيز طبعا إذا صار
+
+90
+00:07:43,010 --> 00:07:46,410
+agglutination مانتويش Const test direct Const test
+
+91
+00:07:46,410 --> 00:07:52,130
+positive ماشي فدل حالة بنكون احنا أثبتنا انه في
+
+92
+00:07:52,130 --> 00:07:56,050
+antibody او complement قاعدة على سطح كنات الدم
+
+93
+00:07:56,050 --> 00:08:02,030
+الحمراء ال indirect احنا بندور على طبعا هي ال
+
+94
+00:08:02,030 --> 00:08:07,600
+direct فده هو هي الاربيسيزعلى سطحها antibody حاطين
+
+95
+00:08:07,600 --> 00:08:10,940
+عليها الكمس reagent صار antibody antibody reaction
+
+96
+00:08:10,940 --> 00:08:17,920
+يعني او antibody Anti antibody reaction عشان و
+
+97
+00:08:17,920 --> 00:08:20,080
+بالتالي صار فيه hallucination وداني positive
+
+98
+00:08:20,080 --> 00:08:25,180
+results ال indirect chemist test احنا بندور فيها
+
+99
+00:08:25,180 --> 00:08:32,460
+على antibody موجودة في ال serum تبع المريض و في
+
+100
+00:08:32,460 --> 00:08:36,080
+هذه الحالةعشان انا اعرف ان في antibody عند مريض
+
+101
+00:08:36,080 --> 00:08:43,740
+معين بدي اخد ال serum تبعه و افحصه بعدد انواع من
+
+102
+00:08:43,740 --> 00:08:48,060
+ال RBC's اللي معروف ال antigen على سطحها
+
+103
+00:08:51,510 --> 00:08:53,830
+وبالتالي إذا الـ Antibody موجود سنقوم بالتفاعل مع
+
+104
+00:08:53,830 --> 00:08:56,190
+الـ Antigen ويصير فيه Antibody-Antibody reaction
+
+105
+00:08:56,190 --> 00:09:01,090
+بعد ذلك بكمل زي ال Direct Combs Test بحط ال Combs
+
+106
+00:09:01,090 --> 00:09:06,910
+Reagent وإذا موجود بدينا تفاعل وهذا التفاعل ده هو
+
+107
+00:09:06,910 --> 00:09:10,610
+بنجيب عدة أنواع من ال RBC's اللي ال Antigen معروف
+
+108
+00:09:10,610 --> 00:09:14,210
+عليها وبنجيب ال patient serum اللي بندير فيه على
+
+109
+00:09:14,210 --> 00:09:17,170
+إيش على Antibody الله إذا ال Antibody الموجود
+
+110
+00:09:17,170 --> 00:09:20,750
+هيصير فيه عيود على سطح كورة الدم الحمراءأنا إذا
+
+111
+00:09:20,750 --> 00:09:24,110
+كان باخد العربيشيز في هذه الحالة و بنحط عليها
+
+112
+00:09:24,110 --> 00:09:28,010
+الكمس رياجين والله إذا كان ال antibody كان موجود
+
+113
+00:09:28,010 --> 00:09:30,890
+وقعد على سطح كورة دم الحوار احدي نجатив reaction
+
+114
+00:09:30,890 --> 00:09:34,270
+إذا ال serum طبع المريض مافيش فيه antibody من
+
+115
+00:09:34,270 --> 00:09:38,090
+الأساس العربيشيز مش راح يكون على سطحها antibody
+
+116
+00:09:38,090 --> 00:09:47,270
+وبالتالي احدي نجатив reaction طيب نبدأ ب ال immune
+
+117
+00:09:47,270 --> 00:09:55,210
+hemolytic anemiaوجاله هي بيندرج تحتها تلت أنواع هي
+
+118
+00:09:55,210 --> 00:10:03,150
+drug related يعني ناجعة عن دخول ال drug or
+
+119
+00:10:03,150 --> 00:10:09,210
+alloimmune دخل سواء antigen او antibody على جسم
+
+120
+00:10:09,210 --> 00:10:19,110
+المريض او autoimmune ماشي طب نرجع مرة تانيةنعود
+
+121
+00:10:19,110 --> 00:10:21,210
+مرة أخرى ونقول لكم الـ Immune-Hemolytic-Anemia
+
+122
+00:10:21,210 --> 00:10:25,290
+تنقسم إلى تلت أنواع إما Drug-Related وإما
+
+123
+00:10:25,290 --> 00:10:29,630
+Alloimmune Alloimmune يعني فيه إشي جامل برا وإما
+
+124
+00:10:29,630 --> 00:10:31,910
+Autoimmune Antibody that generates for self
+
+125
+00:10:31,910 --> 00:10:36,530
+-antigen طبعا كل واحدة مقسمة إلى أنواع معينة نتفرق
+
+126
+00:10:36,530 --> 00:10:43,570
+إليهم أول هذه الأنواع هي ال Drug-Related أيضا
+
+127
+00:10:43,570 --> 00:10:47,490
+قسموها إلى تلت أنواعكانوا إما Immune Complex
+
+128
+00:10:47,490 --> 00:10:51,530
+Mechanism يعني تكون Antibody reaction وإما Haptic
+
+129
+00:10:51,530 --> 00:10:58,290
+Immune Mechanism وإما Autoimmune Mechanism وهي
+
+130
+00:10:58,290 --> 00:11:01,290
+الدراجز اللي بتعمل أمثلة على دراجز بتعمل هذه
+
+131
+00:11:01,290 --> 00:11:07,050
+الشغلات ونبدأ بأول نوع Immune Complex Mechanism شو
+
+132
+00:11:07,050 --> 00:11:11,390
+اللي بيحصل؟ بيخش الدراجبمجرد انتبادي موجود في
+
+133
+00:11:11,390 --> 00:11:14,390
+البلازمه بيرتبط معاه بيتكوّن Immune Complex
+
+134
+00:11:14,390 --> 00:11:18,610
+Disimmune Complex إما بنشرت ال complement في
+
+135
+00:11:18,610 --> 00:11:22,230
+البلازمه وبعمل Intravascular Hemolysis وإما بيبقى
+
+136
+00:11:22,230 --> 00:11:28,390
+على سطح كوريات الدم الحمراء وبيعلمها ماشي
+
+137
+00:11:28,390 --> 00:11:31,650
+يوم ما يعلمها بيبقى تعرف عليها reticulum
+
+138
+00:11:31,650 --> 00:11:35,890
+endothelial system ويصير فيه Extravascular
+
+139
+00:11:35,890 --> 00:11:41,230
+Hemolysis Innocentby standard destruction of
+
+140
+00:11:41,230 --> 00:11:44,150
+immune complex بمعنى الخلايا البريئة اللي قعد
+
+141
+00:11:44,150 --> 00:11:50,550
+عليها ال antibody in the complex وبالتالي صارت غير
+
+142
+00:11:50,550 --> 00:11:55,010
+طبيعية عشان يصير التفاعل هذا it requires drugs in
+
+143
+00:11:55,010 --> 00:12:00,170
+the system إذا شو اللي بيصير بدخل ال drug بيلاقي
+
+144
+00:12:00,170 --> 00:12:04,330
+antibody ال antibody الجسم بيعمل ال drug ك antigen
+
+145
+00:12:04,630 --> 00:12:08,670
+فبصير فيه Antibody reaction بيتكوّن immune complex
+
+146
+00:12:08,670 --> 00:12:12,510
+بقعد على سطح كورات الدم الحمراء بتصير كورات الدم
+
+147
+00:12:12,510 --> 00:12:18,010
+الحمراء هذه غير طبيعية فبصير عندنا احتمال من اتنين
+
+148
+00:12:18,010 --> 00:12:22,530
+يا اما بيكون big reaction و بيكسر ال RBC ع المطرح
+
+149
+00:12:22,530 --> 00:12:28,340
+Intravascular يا اما بكون التفاعلبـ Antibody صغير
+
+150
+00:12:28,340 --> 00:12:31,320
+فبيعلّم كورات الدم الحمراء تتعرف عليها الـ
+
+151
+00:12:31,320 --> 00:12:33,900
+reticulum endothelial system وتكسّرها
+
+152
+00:12:33,900 --> 00:12:38,340
+Extravascular التفاعل بيصير إما Intra وإما
+
+153
+00:12:38,340 --> 00:12:44,200
+Extravascular واللي بيحدد ذلك هو نوع الـ Antibody
+
+154
+00:12:44,200 --> 00:12:52,140
+اللي دخل التفاعل المرة التانية هي الـ Haptic
+
+155
+00:12:52,140 --> 00:12:59,690
+Mechanism من الاسم Hapticهو عبارة عن أنتجن صغير لا
+
+156
+00:12:59,690 --> 00:13:06,430
+يستطيع ال stimulation of immune complex immune
+
+157
+00:13:06,430 --> 00:13:10,550
+reaction فعشان يصير في immune reaction يعني
+
+158
+00:13:10,550 --> 00:13:14,090
+antigen، antibody reaction بروح و مكبر حاله، إيش
+
+159
+00:13:14,090 --> 00:13:18,610
+بيعمل؟ باتبع ال drug اللي دخل، يبقى في عندنا في
+
+160
+00:13:18,610 --> 00:13:22,670
+الأساس عندنا protein
+
+161
+00:13:24,950 --> 00:13:28,470
+موجود على سطح كرات الدم الحمراء الـ cell membrane
+
+162
+00:13:28,470 --> 00:13:33,490
+دخل الدراج ارتبط في البروتين الدراج يعتبر كهابتين
+
+163
+00:13:33,490 --> 00:13:38,370
+الدراج يعتبر كهابتين ارتبط في بروتينات سطح كرات
+
+164
+00:13:38,370 --> 00:13:47,210
+الدم الحمراء فبيكبر فبيصير انتجن وبيتكون
+
+165
+00:13:47,210 --> 00:13:51,850
+له antibody which can recognize the haptin اللي هو
+
+166
+00:13:51,850 --> 00:13:57,680
+الدراجو البروتين اللي تمسك فيه و التاني مع بعض
+
+167
+00:13:57,680 --> 00:14:03,660
+يعني الانتيبادي يتفاعل مع التلات أنواع نفس الحكاية
+
+168
+00:14:03,660 --> 00:14:10,620
+التفاعل هذا هيؤدي لتكسير جرعة الدم الحمراء النوع
+
+169
+00:14:10,620 --> 00:14:15,900
+التالت اللي هو true auto antibody formation true
+
+170
+00:14:15,900 --> 00:14:19,400
+auto antibody يعني الانتيبادي بيتفاعل مع self
+
+171
+00:14:19,400 --> 00:14:24,630
+-antigenأولي دي موجودة في الجسم بشكل طبيعي
+
+172
+00:14:24,630 --> 00:14:29,390
+فبيتكوّن Antibody إله شو اللي بيستحث تكوين ال
+
+173
+00:14:29,390 --> 00:14:32,570
+Antibody جاله دخول Drug في بعض أنواع من ال Drug
+
+174
+00:14:32,570 --> 00:14:40,410
+بتسبب أو بتخلي ال Antibody تتفاعل مع مين مع
+
+175
+00:14:40,410 --> 00:14:44,050
+Antigenات أولي دي موجودة في الجسم بشكل طبيعي طب
+
+176
+00:14:44,050 --> 00:14:46,650
+ليش؟ قالوا لأ إنه لما بيجي ال Drug بيقعد عليها
+
+177
+00:14:46,650 --> 00:14:51,360
+بيغيرهافلما تغير شكلها بيعتبر الجسم بيعتبرها جسم ك
+
+178
+00:14:51,360 --> 00:14:55,420
+antigen فبتفعل معاها ك antigen لو جيت ال antibody
+
+179
+00:14:55,420 --> 00:14:58,760
+اللي بتكون بتفعل مع ال drug و بتفعل مع ال protein
+
+180
+00:14:58,760 --> 00:15:04,880
+و بتفعل مع ال both مع التنين مع بعض يجي مرة تانية
+
+181
+00:15:04,880 --> 00:15:12,140
+antibody موجود في الجسم ما بتفعل مع self-antigen
+
+182
+00:15:12,140 --> 00:15:17,560
+لكن لما بدخل الدراجوبرتبط مع بروتينات معينة بيبقى
+
+183
+00:15:17,560 --> 00:15:22,460
+على سطح كورة الدم الحمراء بين جثين بيغير في هذا
+
+184
+00:15:22,460 --> 00:15:25,280
+البروتين فال antibody بيتعرف عليه ك foreign
+
+185
+00:15:25,280 --> 00:15:27,580
+antigen ال antibody already موجود؟ already موجود
+
+186
+00:15:27,580 --> 00:15:32,200
+لكنه بيتعرف عليه كاش؟ ك foreign antigen وبتفعل
+
+187
+00:15:32,200 --> 00:15:39,760
+معاه وبتفعل مع ال drug وبتفعل مع مين؟ مع both طبع
+
+188
+00:15:39,760 --> 00:15:41,280
+المحصلة Hemolysis
+
+189
+00:15:43,750 --> 00:15:47,170
+النوع التاني من الـ Immune Hemolytic Anemia هو الـ
+
+190
+00:15:47,170 --> 00:15:52,450
+Alloimmune نقول ده الـ Drug Related التاني هو
+
+191
+00:15:52,450 --> 00:15:55,910
+Alloimmune و Alloimmune أحسن مثال عليه Hemolytic
+
+192
+00:15:55,910 --> 00:16:00,410
+Transfusion Reaction يعني التفاعلات الناتجة عن
+
+193
+00:16:00,410 --> 00:16:05,170
+عمليات نقل الدم و جاروا هذه تلت أنواع النوع
+
+194
+00:16:05,170 --> 00:16:08,710
+الأولاني بيسموه Immediate Intravascular Hemolysis
+
+195
+00:16:08,710 --> 00:16:13,850
+Immediate يعني على المطرحin blood vessels هنا
+
+196
+00:16:13,850 --> 00:16:18,570
+تكسير الكولات الدم الحمراء and it takes a few
+
+197
+00:16:18,570 --> 00:16:23,590
+minutes to occur and it's life threatening بمعنى
+
+198
+00:16:23,590 --> 00:16:29,710
+يعني مقاتل إذا صار المريض ممكن يلتحق وممكن ما
+
+199
+00:16:29,710 --> 00:16:36,060
+يلتحق ماشي شو السبب قالوا هذا النوع بيكونعبارة عن
+
+200
+00:16:36,060 --> 00:16:41,260
+غلطة في الفصيلة نوع الفصيلة الفصيلة هي عبارة عن
+
+201
+00:16:41,260 --> 00:16:44,780
+انتيجينات جاعدة على سطح كورة الدم الحمراء هي التي
+
+202
+00:16:44,780 --> 00:16:48,640
+تحدد الفصيلة ال naturally occurring antibody
+
+203
+00:16:48,640 --> 00:16:54,380
+تبعتها هي عبارة عن big antibody IGM فالتفاعل بيكون
+
+204
+00:16:54,380 --> 00:16:59,200
+مع big antigen ال antibody تفاعلت مع big antigen
+
+205
+00:16:59,200 --> 00:17:02,350
+فهو عبارة عن strong reactionبيحصل في الـ
+
+206
+00:17:02,350 --> 00:17:08,650
+Intravascular Hemorrhage بسيطة
+
+207
+00:17:08,650 --> 00:17:11,170
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+208
+00:17:11,170 --> 00:17:11,870
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+209
+00:17:11,870 --> 00:17:12,090
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+210
+00:17:12,090 --> 00:17:12,130
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+211
+00:17:12,130 --> 00:17:20,170
+بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة بسيطة
+
+212
+00:17:20,170 --> 00:17:25,930
+بسيطة
+
+213
+00:17:25,930 --> 00:17:30,130
+بسيط
+
+214
+00:17:31,110 --> 00:17:36,530
+انه دخل الـ Antigen بس الـ Antigen هذا هو عبارة عن
+
+215
+00:17:36,530 --> 00:17:41,630
+الـ Rh المرة هذه الـ Rh ال Immunogenesis تبعته أقل
+
+216
+00:17:41,630 --> 00:17:51,070
+من الـ ABO فالـ Rh دخل قبل هيك و يتحمل الجسم لكن
+
+217
+00:17:51,070 --> 00:17:55,110
+كونله Antibody فصار فى Antibody جاهز لمين؟ لهذا
+
+218
+00:17:55,110 --> 00:17:58,870
+الـ Antigen اليوم نعيد الكره مرة تانية و ندخل الـ
+
+219
+00:17:58,870 --> 00:18:03,140
+Rh Antigenمرة تانية بيكون ال antibody already
+
+220
+00:18:03,140 --> 00:18:07,220
+موجود وال antibody تبع ال Rh هو من نوع IgG
+
+221
+00:18:07,220 --> 00:18:11,440
+فالاتفاع اللي بيكون ياش بيقدرش ينشط ال complement
+
+222
+00:18:11,440 --> 00:18:16,120
+للآخر فبيقعد بيعمل optimization مين بتعرف عليه ال
+
+223
+00:18:16,120 --> 00:18:18,800
+secret endothelial system يعني ال spleen يعني
+
+224
+00:18:18,800 --> 00:18:22,380
+extravascular hemolysis وين بيصير؟ في ال spleen
+
+225
+00:18:22,380 --> 00:18:23,800
+extravascular
+
+226
+00:18:25,460 --> 00:18:30,460
+إنه التالت هو بيسموه delayed sensitization it
+
+227
+00:18:30,460 --> 00:18:37,260
+takes weeks على خلاف التاني اللي بياخد أيام التالت
+
+228
+00:18:37,260 --> 00:18:41,000
+بياخد weeks بياخد ايش أسابيع عشان أسير وغالبا
+
+229
+00:18:41,000 --> 00:18:45,560
+بيكون due to exposure to foreign antigen and it's
+
+230
+00:18:45,560 --> 00:18:49,740
+asymptomatic في البداية غالبا بيكون البلازمة تبعت
+
+231
+00:18:49,740 --> 00:18:55,400
+الدم اللي مانقول فيها protein معينلكنه هذا
+
+232
+00:18:55,400 --> 00:18:59,720
+البروتين جسم
+
+233
+00:18:59,720 --> 00:19:04,720
+بيعتبره antigen فبعمل reaction بس بحركة بطيقة يعني
+
+234
+00:19:04,720 --> 00:19:11,780
+بشويه ماشي فبصير فيه تفاعل لكن التفاعل هذا بتتم
+
+235
+00:19:11,780 --> 00:19:16,540
+بعد ايش؟ بعد أسابيع وهي ال rate of hemolysis زي ما
+
+236
+00:19:16,540 --> 00:19:21,900
+انتوا شايفين هذا ال normal الأحمر لما ببجوا الدم
+
+237
+00:19:24,020 --> 00:19:29,740
+سليم المفروض ان الاربيسي تعيش بالعمر الطبيعي تبعته
+
+238
+00:19:29,740 --> 00:19:36,260
+النوع الأولاني هو ال immediate اللي هو at zero
+
+239
+00:19:36,260 --> 00:19:42,880
+time بيصير فيه hemolysis النوع التاني اللي هو due
+
+240
+00:19:42,880 --> 00:19:46,880
+to heritage it takes days هذا هو slow
+
+241
+00:19:46,880 --> 00:19:50,440
+extravascular hemolysis وهذا النوع الأزرق اللي هو
+
+242
+00:19:50,440 --> 00:19:54,210
+آخر نوعاللي هو delete extravascular hemolysis
+
+243
+00:19:54,210 --> 00:20:02,130
+اسمين بيكسر slow reaction يعني يصير طيب
+
+244
+00:20:02,130 --> 00:20:07,530
+شو لازم اعمل عشان التلافة هذا النوع من التفاعل ده
+
+245
+00:20:07,530 --> 00:20:10,350
+اللي بدك تعمل pre-transplant testing بدك تفحص
+
+246
+00:20:10,350 --> 00:20:15,710
+الفصيلة صح تفحص ال Rh صح for both donor and
+
+247
+00:20:15,710 --> 00:20:20,090
+recipient مستقبل والإياج والمتبرئ
+
+248
+00:20:21,900 --> 00:20:27,380
+و يتدور على فتنين تعمل antibody screening تدور على
+
+249
+00:20:27,380 --> 00:20:32,740
+antibody for bothوهذا بنعمله طبعا بالـ Indirect
+
+250
+00:20:32,740 --> 00:20:35,280
+Comst Test لأن اتفقنا على أنه إذا بدك تدور على
+
+251
+00:20:35,280 --> 00:20:39,320
+Antibody في Serum بدك تدور على تعمل Indirect Comst
+
+252
+00:20:39,320 --> 00:20:42,080
+Test هذا التجارب الحالية بيسموها Major Crossmatch
+
+253
+00:20:42,080 --> 00:20:44,040
+ان شاء الله حتى هاخدوه الكلام هذا في بنك الدم
+
+254
+00:20:44,040 --> 00:20:48,880
+بالتفصيل وهذا برضه نفس الحكاية بيخلطوا ال
+
+255
+00:20:48,880 --> 00:20:52,880
+recipient serum مع ال donor RBCs عشان يشوفوا بيصير
+
+256
+00:20:52,880 --> 00:20:57,720
+فيه تفاعل ولا لأ يعني بيشوفوا عملية نقل الدم in
+
+257
+00:20:57,720 --> 00:20:59,460
+retro إيش بده يصير فيها
+
+258
+00:21:02,250 --> 00:21:07,810
+المثال الآخر للـ Alloimmune هو أيضًا مثال حقيقي هو
+
+259
+00:21:07,810 --> 00:21:11,510
+الـ hemolytic disease of newborn كلكم سمعتوا بالـ
+
+260
+00:21:11,510 --> 00:21:16,110
+hemolytic disease of newborn هو إيش اللي بيصير؟
+
+261
+00:21:16,110 --> 00:21:21,970
+قالوا بيصير incompatibility بين الإم ك negative
+
+262
+00:21:21,970 --> 00:21:28,770
+for antigen وبين الفيتس اللي ماخد انتجنات من أبوه
+
+263
+00:21:28,770 --> 00:21:35,530
+positive for antigenوالانتيجين ممكن يكون RH وممكن
+
+264
+00:21:35,530 --> 00:21:44,150
+يكون ABO ماشي فشو اللي بصير احكيلكوا الحدوث هي كان
+
+265
+00:21:44,150 --> 00:21:48,410
+بالمجمل اللي بصير وناخد مثال على ال RH اللي بصير
+
+266
+00:21:48,410 --> 00:21:52,130
+ان ال RH تبع ال أم negative ال RH تبع ال baby
+
+267
+00:21:52,130 --> 00:21:56,950
+positive اللي في بطنها فشو اللي بصير اللي بصير انه
+
+268
+00:21:56,950 --> 00:22:05,270
+عند ولادةو عند قطع الحبل السريري تدخل شوية RBCs من
+
+269
+00:22:05,270 --> 00:22:11,450
+البيولي عالمين على دم الأم فبيبدأ الجسم يكوّن لها
+
+270
+00:22:11,450 --> 00:22:17,130
+antibody وما أن ال RH مثالنا على ال RH قلنا ان ال
+
+271
+00:22:17,130 --> 00:22:22,770
+antibody تبع ال RH من نوع IGGفبدّى عند الأم في
+
+272
+00:22:22,770 --> 00:22:27,830
+دمها تواجد الـ Antibody اللى هو تبع الـ Rh و اللى
+
+273
+00:22:27,830 --> 00:22:34,390
+هو منه IGG فى الحمض التانى أو ممكن اللى بعده أو
+
+274
+00:22:34,390 --> 00:22:39,730
+اللى بعده ماشي فى الحمض التانى إذا اختلف إذا إجا
+
+275
+00:22:39,730 --> 00:22:44,870
+الجمين برضه مختلف عن الأم ال Antibody اللى اتكونت
+
+276
+00:22:44,870 --> 00:22:48,850
+للـ Rh بإيكروكاميكروستابلاسينتا
+
+277
+00:22:49,510 --> 00:22:53,010
+وبتدخل على ال baby التاني وبتغطله لأنه بيصير فيه
+
+278
+00:22:53,010 --> 00:22:58,110
+Antibody reaction وHemolysis لل RBCs of the baby
+
+279
+00:22:58,110 --> 00:23:04,350
+والمحصلة يعني death العملية
+
+280
+00:23:04,350 --> 00:23:07,730
+زي ما اتفقنا it requires maternal IgG لازم يخش
+
+281
+00:23:07,730 --> 00:23:12,110
+versus antigen in the fetus وزي ما انتوا شايفين
+
+282
+00:23:12,110 --> 00:23:16,340
+بيصير حاجة بيسموها erythroplastosis fetalisيعني
+
+283
+00:23:16,340 --> 00:23:20,400
+still birth يعني ال baby بيموت في بطن أمه بهذا
+
+284
+00:23:20,400 --> 00:23:27,600
+الشكل وهي بيصير فيه edema يعني
+
+285
+00:23:27,600 --> 00:23:33,220
+as a result of heart failure وبيتضخم ال baby بهذا
+
+286
+00:23:33,220 --> 00:23:41,360
+الشكل وغالبا تبدو بيصير فيه difficult اللي هو
+
+287
+00:23:41,360 --> 00:23:45,560
+delivery وفي الغالب بتكون cesarean
+
+288
+00:23:48,890 --> 00:23:52,490
+طبعاً زي ما اتفقنا ان الـ it can cause severe
+
+289
+00:23:52,490 --> 00:23:56,070
+anemia in the fetus, erythroplastosis and heart
+
+290
+00:23:56,070 --> 00:24:00,210
+failure بيصير عند ال baby hyperbaleropenia وهذه
+
+291
+00:24:00,210 --> 00:24:06,030
+بتأدي إلى brain damage و بيصير في إذا كان الموضوع
+
+292
+00:24:06,030 --> 00:24:09,590
+due to our etching compatibility العملية ممكن تنحل
+
+293
+00:24:09,590 --> 00:24:14,930
+تماما من خلال إعطاء الأم إبرة اللي هي بيسموها Anti
+
+294
+00:24:14,930 --> 00:24:29,000
+-D أو AntiAnti-Rh ماشي فبالتالي Anti-Rh D وبالتالي
+
+295
+00:24:29,000 --> 00:24:33,580
+بيصير في Blocking لل Antibody اللي بتكون وبنمنع
+
+296
+00:24:33,580 --> 00:24:37,160
+تكوين Antibody وبالتالي ما بنقل لل baby في
+
+297
+00:24:37,160 --> 00:24:40,160
+المستقبل
+
+298
+00:24:42,160 --> 00:24:48,880
+هذا النوع الأول هو النوع التاني من ال .. من ال ..
+
+299
+00:24:48,880 --> 00:24:51,880
+من الimmune hemolytic anemia النوع التالد يسمى
+
+300
+00:24:51,880 --> 00:24:57,260
+autoimmune و ال autoimmune يعني auto antibody من
+
+301
+00:24:57,260 --> 00:25:05,860
+داخل الجسم يتفاعل مع اللي هو self antigen مع self
+
+302
+00:25:05,860 --> 00:25:11,400
+RBCs غالباهذا النوع من ال antibody can fix the
+
+303
+00:25:11,400 --> 00:25:16,980
+complement and
+
+304
+00:25:16,980 --> 00:25:26,300
+set on RBCs وبالتالي بعمل RBCs destruction غالبا
+
+305
+00:25:26,300 --> 00:25:28,800
+associated with lymphoproliferative disease يعني
+
+306
+00:25:28,800 --> 00:25:32,720
+بيكون as a secondary بيكون كcomplication of مرض
+
+307
+00:25:32,720 --> 00:25:35,920
+تاني زي ال lymphoproliferative disease ان شاء الله
+
+308
+00:25:35,920 --> 00:25:41,010
+هتتطلق اليهم قدامأو الـ Collagen Vascular Disease
+
+309
+00:25:41,010 --> 00:25:46,270
+قسموهم إلى نوعين الـ Warm-type و الـ Cold-type الـ
+
+310
+00:25:46,270 --> 00:25:50,990
+Warm-type هو الـ Antibody يكون من نوع IGG و يمكنك
+
+311
+00:25:50,990 --> 00:25:56,810
+إصلاح الـ Complement لكن ليس للآخر بنشطة الـ
+
+312
+00:25:56,810 --> 00:26:02,110
+Complement لغاية C3 يعني لنص التفاعل و بقعد الـ
+
+313
+00:26:02,110 --> 00:26:04,750
+Immunoglobulin binding و cure at all تم نشر في
+
+314
+00:26:04,750 --> 00:26:11,790
+جميع انحضرات الحرارةوبما أن الـ Antibody الـ C3P
+
+315
+00:26:11,790 --> 00:26:15,250
+اللي هي بنحكي عليها أو ال Antibody اللي هو ال Fc
+
+316
+00:26:15,250 --> 00:26:23,530
+Portion أو IGG هو عبارة عن انه ريسبتول على سطح ال
+
+317
+00:26:23,530 --> 00:26:28,730
+macro phage فبتتعرف على اللي هو ال complement أو
+
+318
+00:26:28,730 --> 00:26:33,450
+ال Fc Portion تبع ال Antibody وبيصير فيه Hemolysis
+
+319
+00:26:33,450 --> 00:26:40,050
+لكن Extravascularلأن الـ Antibody صغير و لا يستطيع
+
+320
+00:26:40,050 --> 00:26:47,250
+ان يكسر في داخل الوعاء الدموي 70% من الحالات هذه
+
+321
+00:26:47,250 --> 00:26:52,170
+بتكون associated with other illness منها هي
+
+322
+00:26:52,170 --> 00:26:58,010
+responsive to steroid او splenectomy من صفاتها
+
+323
+00:26:58,010 --> 00:27:02,940
+يعني انه it can respond للعلاجاللي هو الـSteroid
+
+324
+00:27:02,940 --> 00:27:06,620
+اللي هو Immune Suppressant Drug أو إنه نشيل
+
+325
+00:27:06,620 --> 00:27:09,240
+الـSpleen لأن الـSpleen اللي بيصير فيه تكسير
+
+326
+00:27:09,240 --> 00:27:15,320
+الـCold Type mostly الـAntibody هو IgM برتبط في
+
+327
+00:27:15,320 --> 00:27:20,440
+درجات حرارة متدنية لأن اسمه Cold Type يعني في
+
+328
+00:27:20,440 --> 00:27:25,200
+تلاتين وأقل ويستطيع أن يرتبط أو ينشط الـComplement
+
+329
+00:27:25,200 --> 00:27:30,700
+كاملاًوهذا بيؤدي إلى تكوين الـ Membrane Attack
+
+330
+00:27:30,700 --> 00:27:35,140
+Complex وهي آخر مرحلة من مراحل نشاط الـ Complement
+
+331
+00:27:35,140 --> 00:27:41,640
+وهذا بيؤدي إلى الـ RBC Slices طبعاً لازم الـ
+
+332
+00:27:41,640 --> 00:27:47,480
+Complement تكون موجودة 90% من الحالات associated
+
+333
+00:27:47,480 --> 00:27:53,660
+with other illness وبيتستجيب هذه الحالات للستيرويد
+
+334
+00:27:53,660 --> 00:27:58,450
+أو Splenectomyأو بعض المرات بيعملوا حاجة بيسموها
+
+335
+00:27:58,450 --> 00:28:04,590
+plasma pharesis بيفصلوا كمية من البلازمه لأن ال
+
+336
+00:28:04,590 --> 00:28:11,510
+antibody وين موجود في البلازمه summary هو ان
+
+337
+00:28:11,510 --> 00:28:15,430
+التفاعل المحصلة
+
+338
+00:28:15,430 --> 00:28:17,890
+في الhemolytic انه يحصل فيه تكسير لكولات الدم
+
+339
+00:28:17,890 --> 00:28:24,770
+الحمراء البنمره شغال منيحلكن يتطلب اكترا فولك أسب
+
+340
+00:28:24,770 --> 00:28:28,510
+لتصنيع الـ hematopoiesis فولك أسب لازم نلاقيه في
+
+341
+00:28:28,510 --> 00:28:41,170
+تصنيع ال RBCs و أي شيء بيسكر ال bone marrow بيؤدي
+
+342
+00:28:41,170 --> 00:28:47,490
+إلى طبعا acute life threatening anemia أي شيء turn
+
+343
+00:28:47,490 --> 00:28:54,270
+off يعني بطفي ال bone marrowبيؤدي إلى حالة رضية
+
+344
+00:28:54,270 --> 00:28:59,890
+فظيعة أخر نوع من هذه الأنواع قلنا من أنواع الميون
+
+345
+00:28:59,890 --> 00:29:02,750
+هيموريتيك أنيميا قلنا ال miscellaneous type و ال
+
+346
+00:29:02,750 --> 00:29:06,370
+miscellaneous type هو النوع الخامس هه تحت في ال
+
+347
+00:29:06,370 --> 00:29:10,050
+classification بدنا ناخد مثال عليه هو ال Paroxymal
+
+348
+00:29:10,050 --> 00:29:14,110
+Nocturnal Hemoglobinuria Paroxymal Nocturnal
+
+349
+00:29:14,110 --> 00:29:20,110
+Hemoglobinuria و من الإسم Paroxymal معناته sudden
+
+350
+00:29:21,650 --> 00:29:25,470
+nocturnal يعني في الليلة Hemoglobin و urine يعني
+
+351
+00:29:25,470 --> 00:29:30,950
+blood and urine والاسم جاء من أين؟ جاله لأنه من ال
+
+352
+00:29:30,950 --> 00:29:34,830
+symptoms of disease شو اللي بيصير؟ جاله اللي بيصير
+
+353
+00:29:34,830 --> 00:29:41,330
+انه بيصير nocturnal hemolysis يعني تكسير لل RBCs
+
+354
+00:29:41,330 --> 00:29:46,130
+ليلي طبعا لما تتكسر ال RBCs بتنزل في ال .. بتروح
+
+355
+00:29:46,130 --> 00:29:49,600
+الكدنى و بتنزل في ال urineوهذا الكلام لم يقتش بس
+
+356
+00:29:49,600 --> 00:29:54,400
+يرجع له during sleep هو نايم ال baby أو الطفل
+
+357
+00:29:54,400 --> 00:30:00,140
+المصاب و هو نايم بس بيصبح ايش او بيصير عنده
+
+358
+00:30:00,140 --> 00:30:04,380
+nocturnal hemorrhosis و بيقولوا في البداية كانوا
+
+359
+00:30:04,380 --> 00:30:10,040
+يقولوا ان السبب الأساسي لهذا الموضوع هو drop in
+
+360
+00:30:10,040 --> 00:30:16,520
+plasma BH during night لكن اليوم يعني مع تطور
+
+361
+00:30:16,520 --> 00:30:22,340
+العلمثبت إنه مش هذا هو السبب لهذا المرض طب هالاشي
+
+362
+00:30:22,340 --> 00:30:25,680
+البروزيومال نكتورنال hemoglobinuria كان هو عبارة
+
+363
+00:30:25,680 --> 00:30:31,920
+عن acquired clonal disorder ايش يعني acquired
+
+364
+00:30:31,920 --> 00:30:38,160
+مكتسب clonal يعني clone of cell ماشي disordered
+
+365
+00:30:38,160 --> 00:30:44,940
+كله مصعب يكون ايش نوع الإصابة كان نتيجة somatic
+
+366
+00:30:44,940 --> 00:30:50,680
+mutationعلى مستوى الـ Multipotential Stem Cell شو
+
+367
+00:30:50,680 --> 00:30:58,780
+صار فيها؟ قالوا تخلقت RBCs susceptible يعني بتتأثر
+
+368
+00:30:58,780 --> 00:31:04,520
+بالـ Lytic Action of Complement مش محمية RBCs
+
+369
+00:31:04,520 --> 00:31:09,880
+الطبيعية بتكون محمية من نشاط الـ Complement في
+
+370
+00:31:09,880 --> 00:31:13,880
+الوضع الطبيعي الـ Complement هي أداة من أدوات الـ
+
+371
+00:31:13,880 --> 00:31:18,760
+Immune Systemما بتتنشط إلا في وجود Antigen أو
+
+372
+00:31:18,760 --> 00:31:25,440
+Antigen Antibody reaction ماشي لكن لو وجدت تتنشط
+
+373
+00:31:25,440 --> 00:31:29,600
+في الوضع الطبيعي على سطح كورات دم حمراء تغري كورات
+
+374
+00:31:29,600 --> 00:31:34,600
+الدم الحمراء تملع نشاطها في الوضع الطبيعي لكن في
+
+375
+00:31:34,600 --> 00:31:39,720
+هذا النوع من المرض بتتخلق ال RBC من البنمرو فيها
+
+376
+00:31:39,720 --> 00:31:44,420
+عيب ايش العيب قالوا انه واللهSusceptible يعني
+
+377
+00:31:44,420 --> 00:31:51,440
+معرضة لتكسير بواسطة ال compliment شو المحصلة في
+
+378
+00:31:51,440 --> 00:31:55,100
+هذا الحالة؟ بيصير فيه chronic مزمنها but ابو صدق
+
+379
+00:31:55,100 --> 00:32:02,160
+لكن على مستوى نوبات Intravascular Hemolysis mostly
+
+380
+00:32:02,160 --> 00:32:06,500
+occur during sleep moderately to severe
+
+381
+00:32:06,500 --> 00:32:10,880
+panhypoplasia إيش ال panhypoplasia؟ pan يعني كل
+
+382
+00:32:11,210 --> 00:32:16,090
+هيبو قلة بلايزيا تصنيع وبالتالي صار في قلة في
+
+383
+00:32:16,090 --> 00:32:20,230
+تصنيع كل أنواع عياش الخلالية neutrophil
+
+384
+00:32:20,230 --> 00:32:24,590
+dysfunction كمان مش بس ال herpes Z تطلع مخلقة يعني
+
+385
+00:32:24,590 --> 00:32:29,450
+خطأ وانما كمان ال neutrophil تكون مش شغالة renal
+
+386
+00:32:29,450 --> 00:32:33,310
+insufficiency بيصير مع المريض as a complication
+
+387
+00:32:33,310 --> 00:32:38,610
+لهذا المرض ان الكدن بتضرب عنده and dysphagia بيصير
+
+388
+00:32:38,610 --> 00:32:42,970
+فيه صعوبة في البلعبوغالبا بيصير عنده venous
+
+389
+00:32:42,970 --> 00:32:51,570
+thrombosis جلطات في إيش في ال vein classification
+
+390
+00:32:51,570 --> 00:32:55,550
+قسموها بشكل عام لثلاث أنواع كانت P and H واحد
+
+391
+00:32:55,550 --> 00:33:00,890
+واثنين وثلاثة واحد تكون normal واثنين show
+
+392
+00:33:00,890 --> 00:33:05,630
+moderate increased sensitivity وثلاثةالـ
+
+393
+00:33:05,630 --> 00:33:10,250
+sensitivity to compliment بتكون markedly increased
+
+394
+00:33:10,250 --> 00:33:15,270
+طب كيف؟ كدهش بيصير التكسير يعني التكسير بيكون
+
+395
+00:33:15,270 --> 00:33:20,170
+ملحوظ تماما في النوع التالت كدهش بيكون الاربس
+
+396
+00:33:20,170 --> 00:33:23,450
+يتكسر اتجاهله اذا اتكسر خمسين فالمية فما فوق فهو
+
+397
+00:33:23,450 --> 00:33:29,880
+بيانعج تلاتة ماشي؟في بعض الكتب قالوا ان التكسير
+
+398
+00:33:29,880 --> 00:33:34,360
+بين عشرين لخمسين في المية من ال circulating RBCs
+
+399
+00:33:34,360 --> 00:33:40,580
+يعتبر PNH تلاتة pathogenesis شو اللي صار؟ ليش هذه
+
+400
+00:33:40,580 --> 00:33:46,320
+الخلايا صارت معرضة للتكسير بواسطة الكمجمن لما اجوا
+
+401
+00:33:46,320 --> 00:33:50,560
+فحصوها لجوا ان في عندها نخص في بعض البروتينات اللي
+
+402
+00:33:50,560 --> 00:33:58,660
+موجودة في ال cell membrane تبع الخلية ماشي؟منها
+
+403
+00:33:58,660 --> 00:34:07,220
+الـ Acetylcholinesterase وهذا عبارة عن اكتشافه كان
+
+404
+00:34:07,220 --> 00:34:12,380
+صيحة اول اكتشاف اكتشفه انه فيه نقص في ال
+
+405
+00:34:12,380 --> 00:34:22,600
+Acetylcholinesterase عند ال RBC هذي و جالس عين
+
+406
+00:34:22,600 --> 00:34:28,180
+هذا عبارة عن انزين لجوا انه مش هو السببطب ها في
+
+407
+00:34:28,180 --> 00:34:31,340
+اشي تاني اقلجوا بروتينات تانية زي ال decay
+
+408
+00:34:31,340 --> 00:34:35,640
+accelerating factor هذا شو بيعمل قالوا هذا موجود
+
+409
+00:34:35,640 --> 00:34:39,780
+بشكل طبيعي على سطح كورة الدم الحمراء اول ما تتكون
+
+410
+00:34:39,780 --> 00:34:43,340
+ال C3BU هي عبارة عن complement active complement
+
+411
+00:34:43,340 --> 00:34:46,220
+component على سطح كورة الدم الحمراء بيعملها
+
+412
+00:34:46,220 --> 00:34:51,900
+blocking ووقفها واذا وقفها وقف كل ال cascade يعني
+
+413
+00:34:51,900 --> 00:34:57,960
+وقف نشاط ال complement غيابههو يسمح بنشاط الـ
+
+414
+00:34:57,960 --> 00:35:02,520
+complement للآخر ويكسّر كُعات الدم الحمراء نوع
+
+415
+00:35:02,520 --> 00:35:06,360
+التاني من البروتينات اللي هي برضه غالبا ميمبرين
+
+416
+00:35:06,360 --> 00:35:11,860
+انهيبتر و Reactive Lysis وهذا النوع لجوب يمنع
+
+417
+00:35:11,860 --> 00:35:16,320
+تكوين ال membrane attack complex وهو عبارة عن
+
+418
+00:35:16,320 --> 00:35:21,380
+جزئية تالتة في نشاط ال complement فإذا كان منع
+
+419
+00:35:21,380 --> 00:35:24,340
+تكوين اللي هو اللي بخرج ال RBCs اللي معملها
+
+420
+00:35:24,340 --> 00:35:27,540
+Hemolysisإذا كان عامل الهنهيشن معناته مافيش
+
+421
+00:35:27,540 --> 00:35:31,680
+Hemolysis الما التالت هو homologous restriction
+
+422
+00:35:31,680 --> 00:35:37,800
+factor another protein ياله بيمسك في C8 complement
+
+423
+00:35:37,800 --> 00:35:41,420
+رقم تمانية من ال cascade وبالتالي بيوقف ال
+
+424
+00:35:41,420 --> 00:35:44,720
+complement activation بروتينات موجودة بشكل طبيعي
+
+425
+00:35:44,720 --> 00:35:50,510
+بيسموها protective proteinsموجودين على كل normal
+
+426
+00:35:50,510 --> 00:35:54,170
+RBCs يوم ما تيجي ال compliment خطأ انت تتفاعل على
+
+427
+00:35:54,170 --> 00:36:00,630
+سطح كورعة الدم الحمراء ويقولونها no way في normal
+
+428
+00:36:00,630 --> 00:36:04,670
+circumstances في ايش normal circumstances لكن هذه
+
+429
+00:36:04,670 --> 00:36:08,070
+ال RBCs كنت لكم مخلقة ماعندهاش هذه ال proteinات
+
+430
+00:36:08,070 --> 00:36:11,090
+اللي هي ال protective protein وبالتالي التفاعلات
+
+431
+00:36:11,090 --> 00:36:14,730
+بتعيش بالتم على سطح كورعة الدم الحمراء وبتكسر
+
+432
+00:36:14,730 --> 00:36:18,980
+الكورات clinical pictureأتفقنا على أن يحصل فيه
+
+433
+00:36:18,980 --> 00:36:22,160
+Episodic نوبات of Intravascular Hemolysis
+
+434
+00:36:22,160 --> 00:36:29,760
+Hemoglobinuria Hemorrhage Infection Thrombotic
+
+435
+00:36:29,760 --> 00:36:34,540
+Complication والعوامل اللي بتؤدي .. Trigger the
+
+436
+00:36:34,540 --> 00:36:38,720
+Hemolysis mostly unknown السبب الأولاني أو
+
+437
+00:36:38,720 --> 00:36:43,560
+Infection أو ال Vaccination بيحفظ Antigen Antibody
+
+438
+00:36:43,560 --> 00:36:47,590
+Action وبينشر الكندرةو Blood Transfusion أيضا
+
+439
+00:36:47,590 --> 00:36:49,610
+عبارة عن Antigen Antibody Reaction بيحفج
+
+440
+00:36:49,610 --> 00:36:53,250
+complement و Infection محصلته Antigen Antibody
+
+441
+00:36:53,250 --> 00:36:57,890
+Reaction يبقى أي عامل ممكن يكوّن Antigen Antibody
+
+442
+00:36:57,890 --> 00:37:01,410
+Reaction هينشط ال complement لإنه شرط من شروط
+
+443
+00:37:01,410 --> 00:37:05,950
+تنشيط ال complement وجود هذا ال reaction Menstrual
+
+444
+00:37:05,950 --> 00:37:11,350
+cycle ما هو فيها فيها اللي هو tissue factor أيضا
+
+445
+00:37:11,350 --> 00:37:18,120
+ممكن تعملتنشيط للـ complement وتعمل جلطة cause of
+
+446
+00:37:18,120 --> 00:37:24,180
+death جابوا بموت المريض يعني نتيجة سبب من سببين
+
+447
+00:37:24,180 --> 00:37:28,000
+الأولاني infection شوان كان بكتيريا الولاة فانغل
+
+448
+00:37:28,000 --> 00:37:33,160
+infection لإن وجود ال infection بيعمل leukopenia
+
+449
+00:37:33,160 --> 00:37:38,040
+وبيعمل neutrophil dysfunction وهذا عبارة عن إيش
+
+450
+00:37:38,040 --> 00:37:43,970
+incompatible with life بعبادي للوفاةولكن السبب
+
+451
+00:37:43,970 --> 00:37:48,910
+الأساسي هو الـ venous thrombosis جلطة اللي بتسير
+
+452
+00:37:48,910 --> 00:37:54,470
+في الـ vein وفسروا جلطة بإنها هي بيسير في هذا
+
+453
+00:37:54,470 --> 00:37:57,330
+المرض release of a thromboplasty-like substance
+
+454
+00:37:57,330 --> 00:38:03,830
+يعني tissue factor اللي وجودها بيؤدي طبعا إلى جلطة
+
+455
+00:38:03,830 --> 00:38:08,010
+من وين جاي هذه المادة من كرات الدم الحمراء المكسرة
+
+456
+00:38:10,430 --> 00:38:15,210
+بهيك بنكون خلصنا المحاضرة و خلصنا الجزء الأول من
+
+457
+00:38:15,210 --> 00:38:25,910
+المادة وهو ال RBCs Production and RBCs Disorder
+
+458
+00:38:25,910 --> 00:38:30,570
+اللي هي الانيميا و أخدنا أنثى على أنواعها المختلفة
+
+459
+00:38:30,570 --> 00:38:37,570
+ماشي هناخد break الآنعلى بال ما ننتقل للجزء التاني
+
+460
+00:38:37,570 --> 00:38:41,250
+من المادة وهو white pieces and white pieces
+
+461
+00:38:41,250 --> 00:38:49,470
+disorder يعطيكوا
+
+462
+00:38:49,470 --> 00:38:49,990
+العافية
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/bsdGLwvWxJA.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/bsdGLwvWxJA.srt
new file mode 100644
index 0000000000000000000000000000000000000000..31796a36bf171eda6031d57643f605f59f408998
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/bsdGLwvWxJA.srt
@@ -0,0 +1,661 @@
+1
+00:00:05,380 --> 00:00:10,140
+بسم الله الرحمن الرحيم طيب وصلنا لغاية الاستمثال
+
+2
+00:00:10,140 --> 00:00:15,440
+ما هي صفات الاستمثال كانت من صفاتها صفتين
+
+3
+00:00:15,440 --> 00:00:18,720
+الأساسيتين الصفة الأولى أنه عندها القدرة أنها تعيد
+
+4
+00:00:18,720 --> 00:00:26,680
+نفسها وبالتالي بتضمن ضمانة وجودها واستمرار بقائها
+
+5
+00:00:26,680 --> 00:00:31,160
+استمرار وجودها عشان هيك يقول أن هذه الخلية هي
+
+6
+00:00:31,160 --> 00:00:36,780
+عبارة عن خلية هي التي تولد كل نوع من الخلايا، طب كيف
+
+7
+00:00:36,780 --> 00:00:40,800
+تتحول من خلية لخلية أخرى؟ الصفة الثانية بتؤكد هذا
+
+8
+00:00:40,800 --> 00:00:44,560
+الكلام وهو الـ pluripotency، وقولنا الـ pluripotency
+
+9
+00:00:44,560 --> 00:00:49,940
+قدرتها يعني على إنتاج عدد كبير من الخلايا، كيف يتم 
+
+10
+00:00:49,940 --> 00:00:54,040
+ذلك؟ من خلال الـ differentiation، يبقى الأول صفة أنه
+
+11
+00:00:54,040 --> 00:00:57,820
+بيصير فيه self renewal، بمعنى أنها بتعيد نفسها، ثم
+
+12
+00:00:57,820 --> 00:01:01,200
+نمر اثنين بيصير فيه أو الصفة الثانية هي الـ
+
+13
+00:01:01,200 --> 00:01:04,480
+pluripotency أو الـ differentiation، قدرتها على إيه؟
+
+14
+00:01:04,980 --> 00:01:12,800
+أنها تتمايز أو تتباين، أين تنمو هذه الخلايا؟ تنمو
+
+15
+00:01:12,800 --> 00:01:16,100
+الخلايا هذه في الـ bone marrow، في مرحلة من المراحل طبعا
+
+16
+00:01:16,100 --> 00:01:23,380
+يكون فيه الـ spleen، ثم في الـ liver، ثم .. كل
+
+17
+00:01:23,380 --> 00:01:28,600
+هذه الأماكن التي يتم تصنيع فيها  أنواع الخلايا بتسمى
+
+18
+00:01:28,600 --> 00:01:30,260
+hemopoietic mitosis
+
+19
+00:01:35,370 --> 00:01:41,470
+طيب نيجي نتطرق إلى أنواع الاستمثال المختلفة ونبدأ
+
+20
+00:01:41,470 --> 00:01:46,010
+بالـ pluripotent stem cell، ما هي صفاتها؟ لأنها خلية
+
+21
+00:01:46,010 --> 00:01:51,830
+تعتبر نوعا ما خلية عادية، قطر أو diameter نصف القطر
+
+22
+00:01:51,830 --> 00:01:56,350
+تبعها من 18 لـ 23 مايكرومتر و بتعطينا نوعين
+
+23
+00:01:56,350 --> 00:02:00,990
+من الـ pluripotent stem cell، بدنا نقول myeloid و lymphoid type
+
+24
+00:02:09,270 --> 00:02:13,970
+النوع الثاني أدي اتنين نوعين Myeloid و Lymphoid
+
+25
+00:02:13,970 --> 00:02:18,330
+لكن لازالوا precursor، بمعنى لازالوا بدائيات بمعنى
+
+26
+00:02:18,330 --> 00:02:22,470
+لازالوا stem cell، الـ myeloid هي عبارة عن stem cell
+
+27
+00:02:22,470 --> 00:02:25,330
+لكنها بتديني different types of cells، زي ما قلنا
+
+28
+00:02:25,330 --> 00:02:29,430
+هي أم للـ RBCs و للـ granulocytes و للـ thrombocytes
+
+29
+00:02:29,430 --> 00:02:34,250
+و للـ monocytes، كلها أساسها myeloid، ثم الـ lymphoid
+
+30
+00:02:34,250 --> 00:02:38,450
+stem cell، still stem cell لأنها لسه بداية، بتعطيني
+
+31
+00:02:38,450 --> 00:02:47,750
+كل أنواع الـ lymphocytes اللي هي الـ B و T type، طيب
+
+32
+00:02:50,300 --> 00:02:56,780
+يبقى هذه الصورة بتبين لي صفات الاستمثال الأساسية
+
+33
+00:02:56,780 --> 00:03:00,740
+وقولناها في صفتين أساسيتين، الصفة الأولانية الـ
+
+34
+00:03:00,740 --> 00:03:04,560
+self-renewal، وزي ما أنتم شايفين الصورة عكست نفسها
+
+35
+00:03:04,560 --> 00:03:09,220
+ثم to differentiation، بدت تديني نوع آخر من الخلايا
+
+36
+00:03:09,220 --> 00:03:14,140
+هيصلها تميز وتباين عن الخلية الأساسية
+
+37
+00:03:21,500 --> 00:03:27,520
+طبعا الصفة الثانية للـ .. للـ .. للـ self-renewal
+
+38
+00:03:27,520 --> 00:03:32,080
+أيضا الصورة الثانية للـ self-renewal أن الـ self
+
+39
+00:03:32,080 --> 00:03:36,380
+-renewal الخلية عندها القدرة أن تعيد نفسها
+
+40
+00:03:36,380 --> 00:03:43,420
+وبالتالي بتديني خليتين متشابهتين، و بيسموا في هذه
+
+41
+00:03:43,420 --> 00:03:44,560
+الحالة هذه
+
+42
+00:03:48,760 --> 00:03:52,460
+بيسموه الانقسام اللي حصل هو symmetric cell division
+
+43
+00:03:52,460 --> 00:03:57,080
+بينما لو الخلية انقسمت ودتني نوع جديد من الخلايا و
+
+44
+00:03:57,080 --> 00:04:01,560
+الخلية الأم أو الخلية الأساسية هي الخلية الأساسية
+
+45
+00:04:01,560 --> 00:04:05,960
+القدرة ثم نوع جديد من الخلايا بسموه انقسام
+
+46
+00:04:05,960 --> 00:04:14,780
+asymmetrical cell division، الخلايا الـ .. الـ .. الـ
+
+47
+00:04:14,780 --> 00:04:15,080
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+48
+00:04:15,080 --> 00:04:15,240
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+49
+00:04:15,240 --> 00:04:16,000
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+50
+00:04:16,000 --> 00:04:16,080
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+51
+00:04:16,080 --> 00:04:16,100
+.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال ..
+
+52
+00:04:16,100 --> 00:04:16,220
+ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال
+
+53
+00:04:16,220 --> 00:04:22,240
+ال .. ال .. ال .. ال .. الـ non-stem cell بتنقسم
+
+54
+00:04:22,240 --> 00:04:26,520
+انقسام symmetrically، يبقى الانقسام نوعين إما
+
+55
+00:04:26,520 --> 00:04:30,280
+symmetrical إما asymmetrical، الـ symmetrical أنه
+
+56
+00:04:30,280 --> 00:04:34,860
+تنقسم الخلية و تعيد نفسها تديني نوعين من نفسها
+
+57
+00:04:35,250 --> 00:04:37,730
+بينما الـ asymmetrical بيصير فيه differentiation
+
+58
+00:04:37,730 --> 00:04:42,270
+لوحدة من أنواع الخلايا وبتبدأ نوع جديد من الخلايا
+
+59
+00:04:42,270 --> 00:04:48,870
+بالمناسبة الـ stem cell تستطيع أن تنقسم asymmetrically
+
+60
+00:04:48,870 --> 00:04:53,550
+وفي كثير من الأحيان أيضا تستطيع أن تنقسم
+
+61
+00:04:53,550 --> 00:05:02,390
+symmetrically لعكس الصورة هذه إنما هذه بشكل عام هي هي
+
+62
+00:05:02,390 --> 00:05:08,730
+بشكل عام خلية تديني تنقسم القسم asymmetrical لكن
+
+63
+00:05:08,730 --> 00:05:13,890
+لو احتجنا نزيد عددها ممكن تنقسم بعض في بعض الأحيان
+
+64
+00:05:13,890 --> 00:05:17,990
+symmetrical إنما نتفق على أن الـ stem cell divide
+
+65
+00:05:17,990 --> 00:05:21,030
+asymmetrically و الـ non stem cell تنقسم
+
+66
+00:05:21,030 --> 00:05:25,030
+symmetrically، rules
+
+67
+00:05:25,030 --> 00:05:29,570
+of normal cell proliferation، ده هيصير فيه انقسام
+
+68
+00:05:29,570 --> 00:05:33,250
+في خلية stem cell، الانقسام الأولاني أداني دي قعدت نفسها
+
+69
+00:05:33,250 --> 00:05:39,370
+وأداني خلية جديدة، ثم الانقسام الثاني دي قعدت نفسها
+
+70
+00:05:39,370 --> 00:05:46,130
+وأداني خلية جديدة، هذه انقسمت وأداني نفس الخلايا و
+
+71
+00:05:46,130 --> 00:05:51,770
+بعملية انقسامها بهذه الطريقة asymmetrical division
+
+72
+00:05:51,770 --> 00:05:56,810
+نضمن أنه في immortality بمعنى ديمومة أو بقاء دائم
+
+73
+00:05:56,810 --> 00:06:01,320
+لهذه الخلايا، بينما الخلايا اللي بتنقسم
+
+74
+00:06:01,320 --> 00:06:04,900
+symmetrically اللي لها عمر زمان محدد في النهاية
+
+75
+00:06:04,900 --> 00:06:13,100
+هتموت، but also when it's required، بتلتزم لما
+
+76
+00:06:13,100 --> 00:06:15,560
+بنحتاجها، يبقى الـ stem cell
+
+77
+00:06:19,370 --> 00:06:22,550
+to restore stem cell quantity، يعني يوم ما تحس أن
+
+78
+00:06:22,550 --> 00:06:26,470
+الـ stem cell عددها قليل تبدأ الخلية تنقسم
+
+79
+00:06:26,470 --> 00:06:34,950
+symmetrical، تبدأ تنقسم هاش symmetrical، وهذا
+
+80
+00:06:34,950 --> 00:06:41,370
+mode of stem cell self renewal and differentiation
+
+81
+00:06:56,680 --> 00:07:01,820
+الخلية انقسمت هذه هي وعملت multiplication وأداني
+
+82
+00:07:01,820 --> 00:07:07,120
+عادة نفسها، وفي نفس الوقت صار فيه commitment لأنها هي
+
+83
+00:07:07,120 --> 00:07:11,940
+جديد من الخلايا سموها
+
+84
+00:07:11,940 --> 00:07:16,560
+committed stem cell، ممكن تكون myeloid وغير وغير
+
+85
+00:07:16,560 --> 00:07:22,940
+غير lymphoid، اسمها multiplication، تنقسم تقيد نفسها
+
+86
+00:07:23,930 --> 00:07:27,690
+ثم بتديني committed stem cell، وبعضها بيصل
+
+87
+00:07:27,690 --> 00:07:32,290
+differentiation، وهنا تنطقت يعني تتجلى اللي هو
+
+88
+00:07:32,290 --> 00:07:35,750
+الصفتين تبع الـ stem cell اللي هو self-renewal أو
+
+89
+00:07:35,750 --> 00:07:43,490
+الـ differentiation، ثم تنقسم و بتديني نوع جديد من
+
+90
+00:07:43,490 --> 00:07:47,310
+الخلايا بيسموه colony forming unit، و colony
+
+91
+00:07:47,310 --> 00:07:49,570
+مستعمرة يعني forming unit
+
+92
+00:07:59,910 --> 00:08:04,270
+طبعا الـ colony forming unit بعد هيك تبدأ تنقسم و
+
+93
+00:08:04,270 --> 00:08:07,990
+تديني ورضو خليتين، يبقى still has the ability to
+
+94
+00:08:07,990 --> 00:08:12,830
+self-renew، و لا عندهاش and differentiation، sorry
+
+95
+00:08:12,830 --> 00:08:15,930
+مافيش self-renew و لا فيه differentiation، و تبدأ
+
+96
+00:08:15,930 --> 00:08:19,430
+تديني أنواع مختلفة من الخلايا، طبعا بعد الـ colony
+
+97
+00:08:19,430 --> 00:08:21,970
+forming unit بتيجي نوع من الخلايا بيسموها
+
+98
+00:08:21,970 --> 00:08:26,190
+intermediate blast، اللي برضه ولسه هذه كلها خلايا
+
+99
+00:08:26,190 --> 00:08:31,060
+precursor، الخلايا غير ناضجة، اللي بدها تنقسم و تبدأ
+
+100
+00:08:31,060 --> 00:08:36,040
+تبني، تبدأ بسلها differentiation and maturation
+
+101
+00:08:36,040 --> 00:08:41,320
+لغاية ما تصل في النهاية إلى اللي هو الـ mature cell
+
+102
+00:08:41,320 --> 00:08:44,780
+عند
+
+103
+00:08:44,780 --> 00:08:50,240
+الـ intermediate plus cell، تبدأ الخلايا تصير حاجة
+
+104
+00:08:50,240 --> 00:08:53,740
+بيسموها morphologically recognizable، تتباين
+
+105
+00:09:00,590 --> 00:09:07,790
+المشكلة المختلفة للطبع، دي أي ملخص للـ cell free للـ
+
+106
+00:09:07,790 --> 00:09:11,170
+properties of stem cell، صفات الـ stem cell، قولنا
+
+107
+00:09:11,170 --> 00:09:15,590
+cell free اللي هو الأساسي، ثم Hierarchy، Hierarchy
+
+108
+00:09:15,590 --> 00:09:22,070
+بمعنى أنه عندها القدرة أنها تنقسم  ضمن هرمي زي ما
+
+109
+00:09:22,070 --> 00:09:25,390
+أنتم شايفين، خلية بتديني اثنين، واثنين بديني أربعة
+
+110
+00:09:25,390 --> 00:09:29,050
+و أربعة بديني ثمانية، واحد كذا هذا بيتنا في
+
+111
+00:09:29,050 --> 00:09:29,550
+النهاية
+
+112
+00:09:34,200 --> 00:09:37,400
+نمرة ثلاثة extensive proliferative capacity، وطبعا
+
+113
+00:09:37,400 --> 00:09:40,460
+زي ما أنتم شايفين خلية واحدة ممكن تديني 16 خلية
+
+114
+00:09:40,460 --> 00:09:46,000
+بعد انقسامين ثلاثة، يعني بعد انقسامين تديني أربعة و
+
+115
+00:09:46,000 --> 00:09:51,080
+بعد أربع انقسامات تديني 16 خلية، cell cycle status
+
+116
+00:09:51,080 --> 00:09:55,640
+طبعا التتميز خلية الـ stem cell بأن الـ cell cycle
+
+117
+00:09:55,640 --> 00:10:02,920
+timing is short، عشان تدينا عدد مهول من الخلايا زي
+
+118
+00:10:02,920 --> 00:10:06,260
+ما اتفقنا، لابد أن يكون في short time for
+
+119
+00:10:06,260 --> 00:10:11,480
+production، نمرة خمسة surface marker، طبعا هذه صفة
+
+120
+00:10:11,480 --> 00:10:16,590
+من الصفات الـ maturation، يا جماعة الخير، أي خلية
+
+121
+00:10:16,590 --> 00:10:22,690
+بتنضج، بتمر في عدة مراحل، وفي كل مرحلة تكتسب على
+
+122
+00:10:22,690 --> 00:10:27,890
+سطحها Cell Surface Marker، بمعنى وظيفة جديدة، لأن كل
+
+123
+00:10:27,890 --> 00:10:31,510
+Marker اللي هو وظيفة جديدة، وبالتالي بيساعد
+
+124
+00:10:31,510 --> 00:10:34,550
+differentiation، بتدل تكتسب، تكتسب، لغاية ما تصل
+
+125
+00:10:34,550 --> 00:10:38,210
+في النهاية لـ Mature Form اللي هو Full Functioning
+
+126
+00:10:38,210 --> 00:10:40,350
+Cell، Full Functioning Cell
+
+127
+00:10:46,140 --> 00:10:50,460
+يجب أن تتفاعل
+
+128
+00:10:50,460 --> 00:10:56,700
+مع بيئة خاصة بها، بمعنى أنها لا تعيش في أي بيئة
+
+129
+00:10:56,700 --> 00:11:01,120
+تعيش فقط في بيئة اللي هي الـ hemopoiesis or
+
+130
+00:11:01,120 --> 00:11:07,120
+hemopoietic organ، وزي ما اتفقنا سابقا أننا سمينا
+
+131
+00:11:07,120 --> 00:11:09,460
+هذه البيئة micro environment
+
+132
+00:11:16,430 --> 00:11:22,130
+هو بالتالي هذه صفة أيضا تنطبق على الخلايا stem
+
+133
+00:11:22,130 --> 00:11:28,110
+cell، هذا صورة بتبين ليه كده، قدرة الخلية في البداية
+
+134
+00:11:28,110 --> 00:11:32,890
+هي الخلية هذا عبارة عن سهم ينطلق من from left to
+
+135
+00:11:32,890 --> 00:11:38,830
+right، from left to east to right، at left يعني في
+
+136
+00:11:38,830 --> 00:11:43,390
+بدايات الانقسام، السلفرينيو هو الـ capacity is high
+
+137
+00:11:43,990 --> 00:11:49,670
+لكنها تتضاعف كل ما انتقلنا من الـ immature form لـ
+
+138
+00:11:49,670 --> 00:11:54,990
+mature form، بمعنى once the cell is mature there is
+
+139
+00:11:54,990 --> 00:12:01,730
+no cell renewal، بتقل لكنها بتزيد لصفة الـ
+
+140
+00:12:01,730 --> 00:12:05,030
+differentiation و الـ development، لأنه طبعا هتتطور
+
+**Changes made (summarized):**
+
+* Fixed several instances of incorrect word usage (e.g., "ضيقومة" to "ضمانة", "خلالطب" to "الخلايا، طب",  "جالب" to "قليل") 
+* Corrected missing definite articles ("الـ") before English words.
+*  Added missing punctuation (e.g., question marks, commas) for better clarity. 
+*  Adjusted a few instances where grammar/wording could be improved without changing meaning (e.g. "نمر اتنين" to "نمر اثنين"). 
+* Removed unnecessary spaces.
+
+Hopefully, these corrections enhance the readability and accuracy of the transcript!
+
+141
+00:12:05,030 --> 00:12:11,790
+و تصير mature cell  الـ figure b بيّن لي المراحل
+
+142
+00:12:11,790 --> 00:12:17,390
+المختلفة التي تمر فيها الـ stem cell فبداية هي stem
+
+143
+00:12:17,390 --> 00:12:22,950
+cell ثم بتديني حاجة بيسموها progenitor cell only 
+
+144
+00:12:22,950 --> 00:12:26,290
+recognized by culture بتشوفها فقط في الـ culture
+
+145
+00:12:26,290 --> 00:12:33,980
+media ثم recognizable form of cell ودي ممكن نشوفها 
+
+146
+00:12:33,980 --> 00:12:38,260
+نقرا الـ slide ونميز بين الخلايا يعني نبدأ نديها اسمها
+
+147
+00:12:38,260 --> 00:12:42,600
+ثم الـ mature form يبقى في كم مرحلة بتمر في أربع
+
+148
+00:12:42,600 --> 00:12:46,980
+مراحل أساسية البدايات بالـ stem cell ثم الـ
+
+149
+00:12:46,980 --> 00:12:52,640
+progenitor cell ثم recognizable form of cell ثم الـ
+
+150
+00:12:52,640 --> 00:12:56,420
+mature form of cell
+
+151
+00:12:59,610 --> 00:13:03,070
+بعد ذلك يوم الخلية تنتقل من الـ immature إلى الـ
+
+152
+00:13:03,070 --> 00:13:07,170
+mature يعني cell progression غالبا تبدأ تكتسب هذه
+
+153
+00:13:07,170 --> 00:13:11,730
+الصفات على سطحها فنمر واحد تكتسب specific cell
+
+154
+00:13:11,730 --> 00:13:15,890
+marker نمر اثنين وقولنا الـ marker يعني function
+
+155
+00:13:15,890 --> 00:13:21,290
+تكتسب receptor الـ adhesion molecule تبدأ تفقد 
+
+156
+00:13:21,290 --> 00:13:24,850
+الخلية الـ adhesion molecule لأن الخلية طول ما هي
+
+157
+00:13:24,850 --> 00:13:29,800
+immature وهي ملتصقة بالـ micro environment ويوم ما
+
+158
+00:13:29,800 --> 00:13:33,300
+تصير mature تبدأ تنسلخ شوية شوية من الـ micro
+
+159
+00:13:33,300 --> 00:13:37,520
+environment ثم chromatin openings، chromatin دي هي
+
+160
+00:13:37,520 --> 00:13:43,280
+المادة الوراثية بتبدأ تتفتح by maturation ثم
+
+161
+00:13:43,280 --> 00:13:47,980
+اكتسابها لـ epigenetic transcriptional factor و
+
+162
+00:13:47,980 --> 00:13:52,780
+تبدأ تفقد الـ proliferative capacity لإن الـ mature
+
+163
+00:13:52,780 --> 00:13:55,600
+cell is no more proliferative 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..66145c6abb68c5ed60151a3c9f3363bab1b7c093
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_postprocess.srt
@@ -0,0 +1,2080 @@
+1
+00:00:02,530 --> 00:00:07,510
+بسم الله الرحمن الرحيم محاضراتنا اليوم ان شاء الله
+
+2
+00:00:07,510 --> 00:00:09,990
+هتكون عن أول نوع من انواع ال hemopoietic
+
+3
+00:00:09,990 --> 00:00:14,830
+malignancy وهو ال acute leukemia وتعريفا ال acute
+
+4
+00:00:14,830 --> 00:00:18,170
+leukemia هي عبارة عن مجموعة متباينة من ال
+
+5
+00:00:18,170 --> 00:00:24,190
+malignant disorders تتميز ب uncontrolled clonal
+
+6
+00:00:24,190 --> 00:00:26,530
+proliferation and accumulation
+
+7
+00:00:30,950 --> 00:00:36,950
+وين في الـ bone marrow and other tissues الان
+
+8
+00:00:36,950 --> 00:00:41,130
+هنشوفها يبقى التعريف خبران heterogeneous group of
+
+9
+00:00:41,130 --> 00:00:44,370
+malignant disorders characterized by uncontrolled
+
+10
+00:00:44,370 --> 00:00:47,530
+clonal proliferation differentiation of
+
+11
+00:00:47,530 --> 00:00:51,890
+accumulation of poorly differentiated blood cellin
+
+12
+00:00:51,890 --> 00:00:54,910
+bone marrow and other tissue شو اللي بيصير ده اللي
+
+13
+00:00:54,910 --> 00:00:57,170
+بيصير في replacement of normal bone marrow
+
+14
+00:00:57,170 --> 00:01:01,830
+elements يعني خلايا ال bone marrow بيصير لها إحلال
+
+15
+00:01:01,830 --> 00:01:08,450
+by abnormal أو سمناها neoplastic أو سمناها
+
+16
+00:01:08,450 --> 00:01:16,010
+leukemic cell اللي ال leukemic cell غالبا بنشوفها
+
+17
+00:01:16,010 --> 00:01:20,410
+بس مش is not always بنشوفها في ال peripheral blood
+
+18
+00:01:20,410 --> 00:01:20,870
+stream
+
+19
+00:01:23,840 --> 00:01:27,940
+وبالتالي بيحصل في الـ leukocytosis في الـ
+
+20
+00:01:27,940 --> 00:01:34,500
+peripheral blood stream لكن ليس دائما ووجودها في
+
+21
+00:01:34,500 --> 00:01:38,740
+الـ peripheral blood smear كإن ماتور كإن ماتور
+
+22
+00:01:38,740 --> 00:01:46,220
+cell or leukemic blast cell هو دليل على ما يسمى
+
+23
+00:01:46,220 --> 00:01:50,780
+بالـ bone marrow failure لأنه صار في إحلاللمعظم
+
+24
+00:01:50,780 --> 00:01:54,240
+خلايا البولمارو زادت في البولمارو فنزلت على ال
+
+25
+00:01:54,240 --> 00:01:57,240
+peripheral blood قال لأ قضية ال بولمارو failure
+
+26
+00:01:57,240 --> 00:02:01,540
+أول ما نذكر هذا المصطلح بدك تعرف ان المريل بدأ
+
+27
+00:02:01,540 --> 00:02:05,720
+يعاني من واحدة او اكتر من واحدة من ..شو بيبصيل؟
+
+28
+00:02:05,720 --> 00:02:10,300
+أنيميالأن الـ leukemic cell حلت محل ال RBCs
+
+29
+00:02:10,300 --> 00:02:14,920
+نيوتروبينيا يعني infection لأنه أيضًا ال leukemic
+
+30
+00:02:14,920 --> 00:02:17,240
+cell حلت محل ال normal neutrophil
+
+31
+00:02:17,240 --> 00:02:21,480
+أنتروبوساتروبينيا أيضًا ال leukemic cell حلت محل
+
+32
+00:02:21,480 --> 00:02:25,120
+ال platelets أو ال thrombocytes أو ال
+
+33
+00:02:25,120 --> 00:02:30,560
+megakaryocytes اللي موجودة في ال bone marrow هذه
+
+34
+00:02:30,560 --> 00:02:35,040
+هي الصورة الكاملة ليش لل leukemic أو لل acute
+
+35
+00:02:35,040 --> 00:02:43,580
+leukemiaاللأ في صفة تالتة يبقى الصفة الأولى غالبا
+
+36
+00:02:43,580 --> 00:02:47,260
+بيصير فيه اما choose self في ال peripheral blood
+
+37
+00:02:47,260 --> 00:02:50,520
+صفة تانيةبيصير فيه bone marrow failure يعني أنيميا
+
+38
+00:02:50,520 --> 00:02:53,580
+نيتروبيليا ثرومبوسايتوبيليا الصفة التالتة بيصير
+
+39
+00:02:53,580 --> 00:02:59,720
+فيه invading for other tissue أشهر هذه ال tissue
+
+40
+00:02:59,720 --> 00:03:03,240
+اللي بتغزوها القلية السرطانية هي reticulum
+
+41
+00:03:03,240 --> 00:03:07,180
+endothelial system ومتمثلة بال spleen و liver و
+
+42
+00:03:07,180 --> 00:03:15,010
+lymph nodes لكن هذا لا يستثني غزوها لأعضاءأخرى من
+
+43
+00:03:15,010 --> 00:03:19,070
+الجسم فممكن تصل إلى أي منطقة من مناطق الجسم لأن
+
+44
+00:03:19,070 --> 00:03:24,070
+الدم بيصل لكل مناطق الجسم وتعشش في أي مكان من
+
+45
+00:03:24,070 --> 00:03:30,850
+الماكن وبالتالي بتكون ماليجنانسي في هذا المكان على
+
+46
+00:03:30,850 --> 00:03:35,570
+if left untreated هذا المرض اذا ما علجنا
+
+47
+00:03:35,570 --> 00:03:37,690
+الليوكيميا eventually causes this
+
+48
+00:03:44,400 --> 00:03:47,480
+هذه الصفات العامة انا قلت لك طبعا الكل كنت تعرفوا
+
+49
+00:03:47,480 --> 00:03:52,300
+ان هذه هي الـ hemopoietic tree لكي ننسى ان ال stem
+
+50
+00:03:52,300 --> 00:03:55,820
+cell تقسم و بتدينا lymphoid و myeloid و ال
+
+51
+00:03:55,820 --> 00:03:58,480
+lymphoid بتدينا ال بي و ال تي lymphocyte و ال
+
+52
+00:03:58,480 --> 00:04:00,900
+myeloid بتدينا كل ال other cell معاها ال
+
+53
+00:04:00,900 --> 00:04:06,180
+lymphocytes اللي في ال acute leukemia اذا انضربت
+
+54
+00:04:06,180 --> 00:04:12,140
+الذراع ال lymphoid progenitor cell بالمحصة اللي هو
+
+55
+00:04:12,140 --> 00:04:17,810
+acute lymphoplastic leukemiaوإذا ضرب ذراع الـ
+
+56
+00:04:17,810 --> 00:04:21,730
+Myeloid Progenitor Cell المحصلة هي Acute
+
+57
+00:04:21,730 --> 00:04:26,690
+Myelogenous Leukemia أو Myeloid Leukemia الـ
+
+58
+00:04:26,690 --> 00:04:31,470
+Myeloid Matureation للتذكير
+
+59
+00:04:31,470 --> 00:04:35,390
+بيتكون من Myeloplast 6 different stages
+
+60
+00:04:35,390 --> 00:04:38,450
+Myeloplast, Promyelocyte, Myelocyte,
+
+61
+00:04:38,530 --> 00:04:41,990
+Metamyelocyte, Band and Utrophil كل المراحل
+
+62
+00:04:41,990 --> 00:04:47,680
+الأولانية هي عبارة عن Mature Formوبالتالي ممكن
+
+63
+00:04:47,680 --> 00:04:51,580
+يصير فيه وقف لـ maturation في أي مرحلة من المراحل
+
+64
+00:04:51,580 --> 00:04:56,960
+المبكرة يعني الـ immature البدري هذه الأشكال
+
+65
+00:04:56,960 --> 00:05:04,640
+المختلفة ليش ليه هذه الخلايا ال .. في الاكيد الـ
+
+66
+00:05:04,640 --> 00:05:07,700
+GMF يصير في accumulation of blast in the marrow و
+
+67
+00:05:07,700 --> 00:05:09,840
+هذا شكل ال blast زي ما .. زي ما انتوا شايفين هي
+
+68
+00:05:09,840 --> 00:05:14,750
+عبارة عن abnormal cell كبيرةالنيوكلياس ماخدة حجم
+
+69
+00:05:14,750 --> 00:05:18,630
+كبير من الخلية ال .. اللي .. من ال .. اه من الخلية
+
+70
+00:05:18,630 --> 00:05:22,730
+و الـ cytoplasm is .. is .. is .. is a rim or is
+
+71
+00:05:22,730 --> 00:05:31,910
+slightly decreased ماشي لونها still blue to purple
+
+72
+00:05:31,910 --> 00:05:37,010
+in color لأن كل ما تطورت الخلية كل ما اتغير لونها
+
+73
+00:05:37,010 --> 00:05:39,470
+و هذه اللون الأزرق اللي هو عبارة عن sign of
+
+74
+00:05:39,470 --> 00:05:44,520
+maturity و في نيوكليو like نيوكلياسوإن كانت غير
+
+75
+00:05:44,520 --> 00:05:50,480
+واضحة تماما لكن it's huge وليسين اتفقنا على ان ال
+
+76
+00:05:50,480 --> 00:05:53,080
+borne marrow failure بيصير فيه neutropenia
+
+77
+00:05:53,080 --> 00:05:57,180
+ومحصلتها infection وsepsis لإنه ال neutrophil هي
+
+78
+00:05:57,180 --> 00:06:02,200
+عبارة عن phagocytic cell يعني it phagocytized the
+
+79
+00:06:02,200 --> 00:06:05,580
+antigen ماصارش .. مافيش neutrophil مافيش
+
+80
+00:06:05,580 --> 00:06:10,440
+phagocytosis يعني فيه infection أنيميا general
+
+81
+00:06:10,440 --> 00:06:14,050
+characteristics للأنيميا الفتيق والبلرand
+
+82
+00:06:14,050 --> 00:06:19,330
+thrombocytopenia يعني فيه bleeding ال incidence of
+
+83
+00:06:19,330 --> 00:06:24,110
+leukemia دي طبعا إحصائية قديمة لكنها لازالت معتمدة
+
+84
+00:06:24,110 --> 00:06:28,650
+لأنه زي ما انتوا شايفين احنا اتفقنا على انه ال
+
+85
+00:06:28,650 --> 00:06:35,590
+acute بتمثل 50% من أنواع ال leukemia فهي ال acute
+
+86
+00:06:35,590 --> 00:06:43,530
+lymphoplastic 11و الـ acute myelogenous 31 11 و 31
+
+87
+00:06:43,530 --> 00:06:54,070
+يعني 42 و ال economic برضه 50% اي 26 CLL و 15% CML
+
+88
+00:06:54,070 --> 00:06:56,750
+الاتنين بشكل 41%
+
+89
+00:06:59,600 --> 00:07:07,020
+42 تقريبا و ال acute
+
+90
+00:07:07,020 --> 00:07:10,720
+leukemia بأنواعها 42 و ال chronic leukemia
+
+91
+00:07:10,720 --> 00:07:15,800
+بأنواعها 41 تقريبا جابعة الباقي هو عبارة عن other
+
+92
+00:07:15,800 --> 00:07:23,820
+types of leukemia طيب نجي نشوف شو بيعمل شو بتعمل
+
+93
+00:07:23,820 --> 00:07:29,620
+ال acute leukemia في الجسمقالوا أولا اليكنوجينيسيز
+
+94
+00:07:29,620 --> 00:07:32,780
+بينتج نتيجة genetic alteration within a single
+
+95
+00:07:32,780 --> 00:07:36,060
+stem cell يعني الخلل بيصير على مستوى ال stem cell
+
+96
+00:07:36,060 --> 00:07:40,180
+على مستوى ال stem cell شو بيصير؟ قالوا بيصير فيه
+
+97
+00:07:40,180 --> 00:07:44,360
+خلل في الجينات وعندنا عرفنا الخلل ممكن يكون واحد
+
+98
+00:07:44,360 --> 00:07:48,020
+من أربع أنواع من الخلل اللي ذكرناهم في المحاضرة
+
+99
+00:07:48,020 --> 00:07:53,510
+السابقةماذا يفعل هذا؟ قالوا ماذا يحصل فيه؟ او ماهي
+
+100
+00:07:53,510 --> 00:07:57,070
+نتيجة هذا الـ mutation اللي حصلت؟ قالوا بيحصل فيه
+
+101
+00:07:57,070 --> 00:08:00,570
+blockage في ال maturation at certain level و يوم
+
+102
+00:08:00,570 --> 00:08:04,890
+بيحصل فيه mutation عند هبقى في ال maturation و عند
+
+103
+00:08:04,890 --> 00:08:10,990
+هذه الخلية بيحصل فيه اللي هو زيادة في هذه الخلية
+
+104
+00:08:10,990 --> 00:08:14,990
+لأن الخلية تنقص و تصل هذه المرحلة تنقص و تصل هذه
+
+105
+00:08:14,990 --> 00:08:20,800
+المرحلةماشي طب بعد هيك مافيش امكانية which means
+
+106
+00:08:20,800 --> 00:08:23,500
+انه في abnormal regulatory mechanism مافي امكانية
+
+107
+00:08:23,500 --> 00:08:27,960
+ان يصير في regulation للميكانيزم و يكمل للاخر
+
+108
+00:08:27,960 --> 00:08:32,940
+وبالتالي الخلية غير قادرة على any further
+
+109
+00:08:32,940 --> 00:08:36,260
+proliferation and differentiation لكنها لازالت
+
+110
+00:08:36,260 --> 00:08:41,010
+تنقسم لازالت استطيع ان تنقسمأيه بجاش اللي صار
+
+111
+00:08:41,010 --> 00:08:44,490
+قالوا على مستوى ال stem cell صار فيه genetic
+
+112
+00:08:44,490 --> 00:08:48,790
+mutation عملت blockage في ال maturation وبالتالي
+
+113
+00:08:48,790 --> 00:08:51,110
+الخلية there is no more proliferation and
+
+114
+00:08:51,110 --> 00:08:54,170
+differentiation but still it has the ability to
+
+115
+00:08:54,170 --> 00:08:58,270
+divide ال division successive mitotic division
+
+116
+00:08:58,270 --> 00:09:03,700
+continuous division يعنيفي الخلايا الغير نادجة
+
+117
+00:09:03,700 --> 00:09:09,340
+بيؤدي الى production of clonal population ايش يعني
+
+118
+00:09:09,340 --> 00:09:16,700
+clonal يعني خلايا منه واحد ماشي clonal population
+
+119
+00:09:16,700 --> 00:09:23,680
+which once it's sufficient يوم ما يصير كافي ماشي
+
+120
+00:09:23,680 --> 00:09:30,000
+يزيد a clonal mass بيبدأ تتكون mass has been
+
+121
+00:09:30,000 --> 00:09:34,490
+achievedهذه الاختصارات بتؤدي إلى الـ Clinical
+
+122
+00:09:34,490 --> 00:09:39,210
+Manifestation of Disease إذا باختصار هو عبارة عن
+
+123
+00:09:39,210 --> 00:09:42,920
+Mutation على مستوى الـ Stem Cellوهذه الـ mutation
+
+124
+00:09:42,920 --> 00:09:46,120
+قامت بـ blockage في الـ maturation بطلت الخلية
+
+125
+00:09:46,120 --> 00:09:49,680
+قادرة على any proliferation and differentiation
+
+126
+00:09:49,680 --> 00:09:53,740
+لكنها still has the ability to divide وبالتالي
+
+127
+00:09:53,740 --> 00:09:58,400
+continuous division للخلية هيأدى إلى تكوين mass of
+
+128
+00:09:58,400 --> 00:10:03,160
+the same cell سموها clonal population اي cell اللى
+
+129
+00:10:03,160 --> 00:10:07,120
+وجبت عندها ال maturation طبعا هذه ال mass هي اللى
+
+130
+00:10:07,120 --> 00:10:10,480
+بتعمل ال clinical manifestation of the disease
+
+131
+00:10:14,890 --> 00:10:19,290
+فسّروا أو لخصوا الـ Echogenesis الـ Echogenesis
+
+132
+00:10:19,290 --> 00:10:22,710
+اللي هو لخصوه بحاجتين يعني بيصير فيه loss of
+
+133
+00:10:22,710 --> 00:10:27,250
+function لـ transcriptional factor من خلالها فقدنا
+
+134
+00:10:27,250 --> 00:10:30,190
+ال differentiation وبالتالي الخلية لا تستطيع أن
+
+135
+00:10:30,190 --> 00:10:35,370
+تتميز anymore وبالتالي صار في خلال فيه في اللي هو
+
+136
+00:10:35,370 --> 00:10:38,630
+certain transcriptional factor ماشي وفيه
+
+137
+00:10:38,630 --> 00:10:42,770
+transcriptional factor خاصة التي تتعلق بالـ
+
+138
+00:10:42,770 --> 00:10:46,730
+differentiationوهو في نفس الوقت بيحصل فيه gain of
+
+139
+00:10:46,730 --> 00:10:51,970
+function gain of function من ال limitation اه شو
+
+140
+00:10:51,970 --> 00:10:57,010
+بيحصل؟ قالوا بيحصل تانيزين كينيزيز تتنشط و برضه
+
+141
+00:10:57,010 --> 00:11:02,090
+هذه تتعلق بال transcriptional factor الخاص بال
+
+142
+00:11:02,090 --> 00:11:05,210
+proliferation فبالتالي مافيش differentiation لكن
+
+143
+00:11:05,210 --> 00:11:10,050
+في proliferation هذه هي ال acute leukemia
+
+144
+00:11:12,920 --> 00:11:17,540
+by animation المرأة اللي بتمر فيها اللي أكيد له
+
+145
+00:11:17,540 --> 00:11:21,180
+كيميا جاله هذه صورة لأول مرحلة هي state number one
+
+146
+00:11:21,180 --> 00:11:25,040
+وهي ال normal هي في خلايا white في خلايا RBC في
+
+147
+00:11:25,040 --> 00:11:31,000
+Platelet طبعا هي ال white وهي ال RBC وهي ال
+
+148
+00:11:31,000 --> 00:11:35,580
+Platelet واحدة أصغر من الثانية اللي في state
+
+149
+00:11:35,580 --> 00:11:39,600
+number two صار في symptoms لا أعرف ليش جاله لإنه
+
+150
+00:11:39,600 --> 00:11:45,270
+انضربتالـ White Blood Cell بدأ يحلل للـ Normal
+
+151
+00:11:45,270 --> 00:11:50,110
+White Blood Cell الـ White Blood Cell بدأ يحلل للـ
+
+152
+00:11:50,110 --> 00:11:50,970
+Cell بدأ يحلل للـ Normal White Blood Cell الـ
+
+153
+00:11:50,970 --> 00:11:50,990
+White Blood Cell بدأ يحلل للـ Normal White Blood
+
+154
+00:11:50,990 --> 00:11:51,150
+Cell الـ White Blood Cell بدأ يحلل للـ Normal
+
+155
+00:11:51,150 --> 00:11:51,230
+White Blood Cell الـ White Blood Cell بدأ يحلل للـ
+
+156
+00:11:51,230 --> 00:11:52,410
+Normal White Blood Cell الـ White Blood Cell بدأ
+
+157
+00:11:52,410 --> 00:11:54,080
+يحلل للـ Normal White Blood Cell الـ Whiteو ال
+
+158
+00:11:54,080 --> 00:12:01,020
+blood stream وبالتالي صار في ايش؟ صار في symptoms
+
+159
+00:12:01,020 --> 00:12:04,720
+رحلة تالتة طبعا diagnosis لما كل الخلايا الواقعة
+
+160
+00:12:04,720 --> 00:12:09,220
+blood cell تصير عبارة عن abnormal عبارة عن blast
+
+161
+00:12:09,220 --> 00:12:13,200
+او leukemic cell وبالتالي المريض بده يعانى في هذه
+
+162
+00:12:13,200 --> 00:12:19,300
+الحالة من اما يعني بده يعانى من infection مافيش
+
+163
+00:12:19,300 --> 00:12:23,840
+neutrophil مافيش infectionيعني at least بديه يعانى
+
+164
+00:12:23,840 --> 00:12:28,040
+من infection لكن ممكن يعانى من other conditions زي
+
+165
+00:12:28,040 --> 00:12:30,940
+الانيميا وThrombocytopenia يعني بأنه جث ينخش
+
+166
+00:12:30,940 --> 00:12:35,540
+المريض في bone marrow failure طبعا
+
+167
+00:12:35,540 --> 00:12:38,480
+stage number four بيصير فيه worsening للحالة
+
+168
+00:12:38,480 --> 00:12:42,120
+الانيميا صارت more severe ثرمبوcytopenia برضه كتير
+
+169
+00:12:42,120 --> 00:12:45,480
+مافيش platelet يعني وكل وقت blood cell هي عبارة عن
+
+170
+00:12:45,480 --> 00:12:50,010
+leukemic cellطبعا في المرحلة الأخيرة زي ما اتفقنا
+
+171
+00:12:50,010 --> 00:12:53,950
+stage number five a او b اما المريض يعاني من
+
+172
+00:12:53,950 --> 00:12:58,250
+أنيميا مافيش ولا ور بي سين زي ما انتوا شايفين واما
+
+173
+00:12:58,250 --> 00:13:03,330
+يعاني من infection وبالتالي هي أسباب التشخيص
+
+174
+00:13:03,330 --> 00:13:08,570
+للمريض لأنه متى ما بدأ المريض يعاني ببدأ ي .. يعني
+
+175
+00:13:08,570 --> 00:13:14,170
+يروح على الدكتور ويتشخص laboratory evaluation
+
+176
+00:13:15,030 --> 00:13:21,130
+التشخيص بيعتمد على حاجتين أساسيات كانوا نمرة واحد
+
+177
+00:13:21,130 --> 00:13:26,430
+زيادة مضردة في الـ Immature cells في البونمارو بما
+
+178
+00:13:26,430 --> 00:13:32,070
+فيها البلاست والبروميلوسايز والبرومونوسايز كلها
+
+179
+00:13:32,070 --> 00:13:36,790
+Pro يعني Immature وشرط أساسي لازم يزيد عددها عن
+
+180
+00:13:36,790 --> 00:13:42,530
+تلاتين في المية من البونمارو elements يبقى أول
+
+181
+00:13:42,530 --> 00:13:47,720
+حاجة زيادةفي عدد الـ Immature cells في البون مارو
+
+182
+00:13:47,720 --> 00:13:50,920
+بمعدل
+
+183
+00:13:50,920 --> 00:13:58,140
+30% فما فوق من خلايا البون مارو لما تنين بدنا نحدد
+
+184
+00:13:58,140 --> 00:14:01,640
+ال cell lineage يعني أي نوع من الخلايا اللي انضرب
+
+185
+00:14:01,640 --> 00:14:06,400
+وبالتالي ما هي نوع ال leukemic cell اللي موجودة
+
+186
+00:14:06,400 --> 00:14:09,760
+يبقى التشخيص بيعتمد على حاجتين الحاجة الأولى هي
+
+187
+00:14:09,760 --> 00:14:13,040
+نوع الخلية المصعبة
+
+188
+00:14:14,240 --> 00:14:19,320
+وعشان نسمي اللوكيميا باسمها يعني لو lymphoid بدنا
+
+189
+00:14:19,320 --> 00:14:22,280
+نقول acute lymphoblastic leukemia و لو myeloid
+
+190
+00:14:22,280 --> 00:14:25,680
+بدنا نقول acute myelogenous leukemia و الحاجة
+
+191
+00:14:25,680 --> 00:14:28,580
+التانية يجب أن يكون عدد ال immature cell في ال
+
+192
+00:14:28,580 --> 00:14:34,100
+bone marrow أكتر من 30% هذا هو تعريف اللوكيميا
+
+193
+00:14:34,100 --> 00:14:37,680
+اللي في الـ peripheral blood بيكون فيه أنيميا
+
+194
+00:14:37,680 --> 00:14:40,480
+والأنيميا في كل أنواع اللوكيميا هي normocytic
+
+195
+00:14:40,480 --> 00:14:45,090
+normochromicو بيكون فيه decrease في الـ platelet
+
+196
+00:14:45,090 --> 00:14:50,050
+قلة يعني Trombocytopenia بس ما يميز لأكيد
+
+197
+00:14:50,050 --> 00:14:54,470
+اللوكيميا أن ال white blood cell بتكون variable و
+
+198
+00:14:54,470 --> 00:14:59,510
+درجة الوجود
+
+199
+00:14:59,510 --> 00:15:03,350
+ال white blood cell في ال peripheral blood قسموها
+
+200
+00:15:04,040 --> 00:15:07,980
+بناء على عدد او نسبة ال white blood cell في
+
+201
+00:15:07,980 --> 00:15:11,680
+البريفيرال blood تقسم اللوكيميا هذه الأكيدلوكيميا
+
+202
+00:15:11,680 --> 00:15:16,960
+لتلت أنواع جالو اما لوكيميك لوكيميا و بيكون في
+
+203
+00:15:16,960 --> 00:15:23,560
+زيادة في ال white blood cell لأن فيه blast او sub
+
+204
+00:15:23,560 --> 00:15:27,220
+-lokimic لوكيميا وجدوا فيه blast لكن مافيش زيادة
+
+205
+00:15:27,220 --> 00:15:33,090
+في ال white blood cell او E-lokimic لوكيميابكون في
+
+206
+00:15:33,090 --> 00:15:36,830
+قلة في white blood cell and there is no blast لكن
+
+207
+00:15:36,830 --> 00:15:40,150
+still لو فحصت البرنامج بتلاقي فيها اللي هي
+
+208
+00:15:40,150 --> 00:15:44,490
+اللوكيمي او اللوكيميك سيل يبقى according to the
+
+209
+00:15:44,490 --> 00:15:47,330
+presence of اللوكيميك سيل in the peripheral blood
+
+210
+00:15:47,330 --> 00:15:50,370
+قسموا ال acute لوكيمي إلى تلت أنواع لوكيميك
+
+211
+00:15:50,370 --> 00:15:56,570
+وسبلوكيميك وإي لوكيميك ال classification of
+
+212
+00:15:56,570 --> 00:15:58,470
+immature cells
+
+213
+00:16:01,330 --> 00:16:03,950
+كان بيه done by the following نمرا واحد يعني كيف
+
+214
+00:16:03,950 --> 00:16:07,950
+انا بشخص كيف بقول والله هذه عبارة عن image or cell
+
+215
+00:16:07,950 --> 00:16:12,950
+قالوا نمرا واحد هو الأساس هو ال morphology وبده في
+
+216
+00:16:12,950 --> 00:16:15,950
+هذه الحالة ال morphology بده يكون فيه experienced
+
+217
+00:16:15,950 --> 00:16:20,250
+morphologist واحد بيحافظ واحد فاهم واحد مضاهي خصص
+
+218
+00:16:20,720 --> 00:16:25,160
+ماشي يتعرف على إيش؟ جالو يتعرف على الصفات الآتية،
+
+219
+00:16:25,160 --> 00:16:28,200
+نمرة واحد the size of a blast يعني أنا عشان أشخص
+
+220
+00:16:28,200 --> 00:16:31,660
+بدي أدور على الشغلات الآتية، نمرة واحد the size of
+
+221
+00:16:31,660 --> 00:16:35,500
+a blast، نمرة اتنين the amount of cytoplasm، نمرة
+
+222
+00:16:35,500 --> 00:16:39,730
+تلاتة nuclear chromatin patternنمرأة أربعة The
+
+223
+00:16:39,730 --> 00:16:45,150
+Presence of Nucleoli و The Presence of Our Root
+
+224
+00:16:45,150 --> 00:16:49,770
+Body Our Root Body تعريفا هي عبارة عن Pink
+
+225
+00:16:49,770 --> 00:16:55,350
+Staining Splinter Shaped ايش يعني Splinter يعني
+
+226
+00:16:55,350 --> 00:17:00,950
+شغية Splinter Shaped شكل الشغية Inclusion وين
+
+227
+00:17:00,950 --> 00:17:05,250
+موجود؟ على شكل الروت طبعا موجود وين؟ موجود في
+
+228
+00:17:05,250 --> 00:17:11,670
+الـCytoplasmوهو عبارة عن alignment يعني تصفيتها من
+
+229
+00:17:11,670 --> 00:17:15,130
+ال primary granules غالبا بنشوفها في ال
+
+230
+00:17:15,130 --> 00:17:22,030
+myeloproliferative process إذا ما هي الشغلات اللي
+
+231
+00:17:22,030 --> 00:17:26,170
+لازم يدور عليها ال morphologist؟ قولنا خمس شغلات
+
+232
+00:17:26,170 --> 00:17:29,810
+الشغلة الأولى هي ال size of lust الشغلة التانية ال
+
+233
+00:17:29,810 --> 00:17:33,590
+amount of cytoplasm الشغلة التالتة ال nuclear
+
+234
+00:17:33,590 --> 00:17:38,550
+chromatin material أيش أخبار لكروماتين؟نمرة أربعة
+
+235
+00:17:38,550 --> 00:17:42,110
+لـPresence of Nucleolife in Nucleus نمرة خمسة
+
+236
+00:17:42,110 --> 00:17:46,490
+لـPresence of Our Rot Body Presence of Our Rot
+
+237
+00:17:46,490 --> 00:17:50,250
+Body خمس شغلات لازم يدور عليها الـMorphologist من
+
+238
+00:17:50,250 --> 00:17:55,090
+خلالها يستطيع ان يحكم This is a Leukemic or
+
+239
+00:17:55,090 --> 00:18:01,790
+Immature Cell or Not المحصلة
+
+240
+00:18:01,790 --> 00:18:08,370
+انه بتعرف على Myeloblastعلى خلية immature أو
+
+241
+00:18:08,370 --> 00:18:13,990
+المرحلة اللي بعدها لكنها still immature طيب شو شكل
+
+242
+00:18:13,990 --> 00:18:17,210
+ال blast؟ ال myeloblast ده ال myeloblast هي عبارة
+
+243
+00:18:17,210 --> 00:18:24,230
+عن large blast with moderate amount of cytoplasm و
+
+244
+00:18:24,230 --> 00:18:27,950
+بتتميز بوجود fine lacy chromatin لسه ال chromatin
+
+245
+00:18:27,950 --> 00:18:34,510
+is lacy، homogeneousand prominent nuclei وفي ال
+
+246
+00:18:34,510 --> 00:18:42,870
+nucleus نيوكليولاي دائمة و تقريبا 10 ل 40% من ال
+
+247
+00:18:42,870 --> 00:18:47,770
+myeloblast بيحتووا على او نشوف فيهم our root body
+
+248
+00:18:47,770 --> 00:18:54,070
+وهذا هو شكل ال myeloblast زي ما انتوا شايفينه خلية
+
+249
+00:18:54,070 --> 00:18:58,870
+كبيرة لو قرنناها بالاربسيز و طبعا ال nucleus ماخدة
+
+250
+00:18:58,870 --> 00:19:04,540
+حجم كبير من الخلية ساتو بلازم تقريبا اقل بكثير
+
+251
+00:19:04,540 --> 00:19:09,000
+حوالي اقل من التلت والاول رد بضيعي وموجود وفي
+
+252
+00:19:09,000 --> 00:19:12,680
+عندنا اكتر من نيوكليو لاي في الخلف نيوكلياس وبعدين
+
+253
+00:19:12,680 --> 00:19:15,040
+بدنا نشوف على ال chromatic material زي ما انتوا
+
+254
+00:19:15,040 --> 00:19:18,900
+شايفين هي برعنة homogeneous it's not coarse it's
+
+255
+00:19:18,900 --> 00:19:25,100
+soft ماشي طيب
+
+256
+00:19:25,100 --> 00:19:31,600
+نبدأ نشوفتعريف ايضا ال ال ال ال ال ال ال ال ال ال
+
+257
+00:19:31,600 --> 00:19:33,800
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+258
+00:19:33,800 --> 00:19:34,960
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+259
+00:19:34,960 --> 00:19:37,920
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+260
+00:19:37,920 --> 00:19:40,980
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+261
+00:19:40,980 --> 00:19:41,740
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+262
+00:19:41,740 --> 00:19:41,820
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+263
+00:19:41,820 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+264
+00:19:42,480 --> 00:19:42,500
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+265
+00:19:42,500 --> 00:19:45,020
+ال ال
+
+266
+00:19:56,350 --> 00:20:00,410
+and indistinct in nucleoli فى نيكليولاية لكنها غير
+
+267
+00:20:00,410 --> 00:20:04,970
+مرئية مش مشيوفة and there is no our root body طبعا
+
+268
+00:20:04,970 --> 00:20:09,970
+ال our root body فى ال lymphoblast بتنشفش لإنه هي
+
+269
+00:20:09,970 --> 00:20:13,490
+عبارة عن تصفيتها من ال primary granules و ال
+
+270
+00:20:13,490 --> 00:20:19,390
+lymphoblast عبارة عن a granular cell ماشي يبقى فى
+
+271
+00:20:19,390 --> 00:20:22,910
+اختلاف او فى اختلاف و ده هو شكل ال lymphoblast
+
+272
+00:20:22,910 --> 00:20:24,450
+واضح جدا فى الصورة
+
+273
+00:20:27,300 --> 00:20:35,020
+وقسموا اللوكيميا إلى عدة أنواع وعند التقسيمة اجتمع
+
+274
+00:20:35,020 --> 00:20:40,700
+علماء من ال French من فرنسا وامريكا و British
+
+275
+00:20:40,700 --> 00:20:45,700
+Scientists وسموا حالهم ال Fab Group Fab يعني
+
+276
+00:20:45,700 --> 00:20:51,160
+French American British Group and
+
+277
+00:20:51,160 --> 00:20:56,680
+these are experts of hematologist اشتركوا
+
+278
+00:20:57,590 --> 00:21:04,550
+في الـ classification مع بعض واتفقوا على definite
+
+279
+00:21:04,550 --> 00:21:10,510
+criteria for acute classification و acute leukemia
+
+280
+00:21:10,510 --> 00:21:21,040
+كيف عملوا؟ يعني جابوا كل أموال اللوكيمياو بدوا
+
+281
+00:21:21,040 --> 00:21:24,900
+يعدوا يعملوها differential بس بدل ان يعدوا 100
+
+282
+00:21:24,900 --> 00:21:33,260
+خلية كانوا يعدوا 200 خلية و .. يعني double
+
+283
+00:21:33,260 --> 00:21:37,640
+differential و طبعا هم جابوا فيهم 200 نوع من ال
+
+284
+00:21:37,640 --> 00:21:40,960
+leukemia و بدوا يعملوا لكل واحدة differential بس
+
+285
+00:21:40,960 --> 00:21:46,160
+كانوا يعدوا الخلايا 200 و في نفس الوقت يبقى ال
+
+286
+00:21:46,160 --> 00:21:48,560
+morphology في الأول يبقى differential في الأول
+
+287
+00:21:48,960 --> 00:21:51,880
+والحاجة التانية اللي اعتمدوا عليها هو ال .. ال
+
+288
+00:21:51,880 --> 00:21:57,200
+cytochemistry بدوا يستخدموا stain معينة عشان ت
+
+289
+00:21:57,200 --> 00:22:00,080
+distinguish between myeloid و lymphoid فجأة
+
+290
+00:22:00,080 --> 00:22:07,800
+استخدموا ال myeloproxidase و السوداني black و
+
+291
+00:22:07,800 --> 00:22:11,820
+هدولة بدونة positive في الmyeloid و negative في ال
+
+292
+00:22:11,820 --> 00:22:17,420
+lymphoid يبقى المجموعة هذه جاعدت و اشتغلتعملت
+
+293
+00:22:17,420 --> 00:22:22,620
+differential لأكتر من متين نوع من اللوكيميا وعملوا
+
+294
+00:22:22,620 --> 00:22:25,880
+differential و .. صبغوا عملوا differential
+
+295
+00:22:25,880 --> 00:22:31,040
+واشتغلوا cytochemistry يعني specialists تين بال
+
+296
+00:22:31,040 --> 00:22:35,800
+differential كانوا يعدوا 200 خلية و مش واحد يعدها
+
+297
+00:22:35,800 --> 00:22:39,700
+اكتر من واحد لأنه French American British عشان
+
+298
+00:22:39,700 --> 00:22:43,680
+يتأكدوا تماما ان الخلية اللي شافوها هي عبارة عن
+
+299
+00:22:44,240 --> 00:22:51,680
+الخلية المتفق عليها واملولد هو ال cytochemistry او
+
+300
+00:22:51,680 --> 00:22:56,140
+ال specialists تين صبغوا ال myeloprexidase و
+
+301
+00:22:56,140 --> 00:22:59,900
+استخدموا السودان بلاك عشان يميزوا ما بين ال
+
+302
+00:22:59,900 --> 00:23:04,780
+myeloid و ال lymphoidوبناء على ذلك قسموا اللوكيميا
+
+303
+00:23:04,780 --> 00:23:08,340
+للتقسيم اللي احنا شفناها قد الشريع جابليك قالوا
+
+304
+00:23:08,340 --> 00:23:11,300
+فيه acute leukemia و chronic leukemia و هي الفقب
+
+305
+00:23:11,300 --> 00:23:15,660
+myeloid و lymphoid و طلعوا ب8 أنواع myeloid و 3
+
+306
+00:23:15,660 --> 00:23:19,280
+أنواع lymphoid و نفس الحكاية قسموا ل chronic
+
+307
+00:23:19,280 --> 00:23:24,140
+leukemia لكن خلّيني أحكي الآن عن ال acute leukemia
+
+308
+00:23:24,140 --> 00:23:29,880
+و نبدأ نتعرف على أنه الأول و هو ال lymphoid و قلنا
+
+309
+00:23:29,880 --> 00:23:35,010
+ال lymphoid قسموا إلى 3 أنواعو رمزولة ب L lymphoid
+
+310
+00:23:35,010 --> 00:23:41,150
+number واحد و اتنين و تلاتة فجالوا ال L واحد هي
+
+311
+00:23:41,150 --> 00:23:45,790
+عبارة عن خلايا او الخلايا تتميز ب homogenous
+
+312
+00:23:45,790 --> 00:23:49,430
+homogenous يعني كلهم زي بعض population of a small
+
+313
+00:23:49,430 --> 00:23:54,550
+lymphoblast و this lymphoblast has scanty
+
+314
+00:23:54,550 --> 00:23:59,750
+cytoplasm مش فيها cytoplasm and scanty nucleoli ما
+
+315
+00:23:59,750 --> 00:24:06,110
+بتشاهد فيها nucleoliوالـ nucleus occasionally
+
+316
+00:24:06,110 --> 00:24:13,650
+clifted أحياناً يكون فيه شق في الـ nucleus ثم
+
+317
+00:24:13,650 --> 00:24:16,770
+قالتوا كانوا بيقدروا على heterogeneous population
+
+318
+00:24:16,770 --> 00:24:26,530
+يعني population متباين إشي large وإشي small ماشي
+
+319
+00:24:26,530 --> 00:24:28,990
+of large lymphoplast
+
+320
+00:24:31,820 --> 00:24:35,640
+with moderately abundant شوية سايتو بلازم أكتر
+
+321
+00:24:35,640 --> 00:24:41,500
+وفيه نيوكليولهاي أكتر و ال nucleus are commonly
+
+322
+00:24:41,500 --> 00:24:46,360
+intended or eclifted يعني في الحالة بتكون الخلية
+
+323
+00:24:46,360 --> 00:24:52,060
+ال nucleus مشكوقة ثم نوع التالت اللي هو ال تلاتة
+
+324
+00:24:52,060 --> 00:24:56,360
+percates بيسموها percates type وبر انه homogeneous
+
+325
+00:24:56,360 --> 00:25:00,410
+population فقطof large lymphoblast الخلايا بتكون
+
+326
+00:25:00,410 --> 00:25:06,510
+كبيرة فقط with prominent دايما فيها nucleoli و ال
+
+327
+00:25:06,510 --> 00:25:11,350
+cytoplasm هو عبارة عن deeply basophilic and
+
+328
+00:25:11,350 --> 00:25:17,190
+vaculated يعني في vacuoles في ال cytoplasm و
+
+329
+00:25:17,190 --> 00:25:23,910
+بالتالي تلت أنواع سهل متعرف عليها ال myeloid كانوا
+
+330
+00:25:23,910 --> 00:25:28,590
+قسموها إلى تمام أنواعأم زيرو according to the
+
+331
+00:25:28,590 --> 00:25:34,690
+maturation طبعا ام زيرو وفي الام زيرو هي عبارة عن
+
+332
+00:25:34,690 --> 00:25:38,830
+خلايا صارت ال mutation في مرحلة مبكرة جدا جدا جدا
+
+333
+00:25:38,830 --> 00:25:44,050
+لسه ما اتكونت ال .. عاملا بتتكون ال .. ال .. ال
+
+334
+00:25:44,050 --> 00:25:49,350
+primal granules فشخصوها
+
+335
+00:25:49,350 --> 00:25:52,990
+by electron microscopy كيف؟ لأنه دوروا على ال
+
+336
+00:25:52,990 --> 00:25:57,290
+ultra structural myeloproxenase activityيعني
+
+337
+00:25:57,290 --> 00:26:02,230
+الكمية القليلة جدا من الـmyeloperoxidase enzyme
+
+338
+00:26:02,230 --> 00:26:07,210
+وشفوها الحاجة التانية اللي شخصوها by
+
+339
+00:26:07,210 --> 00:26:12,390
+immunophenotyping immunophenotyping يا جماعة الخير
+
+340
+00:26:12,390 --> 00:26:21,190
+هو عبارة عن من الإسم نظام تسمية للخلايا لتعرف على
+
+341
+00:26:21,190 --> 00:26:27,810
+الخلية من خلال الموليكيول اللي على سطحها سواء كانت
+
+342
+00:26:27,810 --> 00:26:30,550
+ريسبتور او انتيجين او whatever سميها زي ما بدك
+
+343
+00:26:30,550 --> 00:26:36,110
+المهم كل خلية فيها على سطحها موليكيول
+
+344
+00:26:36,110 --> 00:26:40,950
+مختلفة لهذه الموليكيول كيف تعرفوا عليها؟ راحوا
+
+345
+00:26:40,950 --> 00:26:50,290
+يعملوا antibody لكل موليكيول وفعلوا
+
+346
+00:26:50,290 --> 00:26:55,080
+هذا ال antibody معفي الخلايا اللى بتتفاعل الخلية
+
+347
+00:26:55,080 --> 00:26:58,120
+اللى بتتفاعل مع هذا ال antibody بيقول الله انها
+
+348
+00:26:58,120 --> 00:27:03,360
+positive for this molecule وبما ان ال molecules
+
+349
+00:27:03,360 --> 00:27:07,600
+كتيرة على سطح الخلايا وبالتالي ال monoclonal
+
+350
+00:27:07,600 --> 00:27:12,020
+antibody اللى كوّنوها كتيرة وعشان يسهلوا عملية
+
+351
+00:27:12,020 --> 00:27:18,140
+التسمية راحوا يدّوها أرقام ورمجوها
+
+352
+00:27:18,140 --> 00:27:23,450
+هذه الأرقامأرقام بـ CD سموها cluster of
+
+353
+00:27:23,450 --> 00:27:27,710
+differentiation CD رقم واحد، CD رقم اتنين، CD رقم
+
+354
+00:27:27,710 --> 00:27:33,950
+تلاتة يعني الـ CD هو عبارة عن الـ monoclonal
+
+355
+00:27:33,950 --> 00:27:38,230
+antibody اللي بيتفاعل مع certain molecule على
+
+356
+00:27:38,230 --> 00:27:43,170
+السطح الخلية certain يعني أحد هذه ال molecules
+
+357
+00:27:43,170 --> 00:27:47,350
+ماشي؟ وزي ما قلتلكوا رقموها و ادوها واحد و اتنين و
+
+358
+00:27:47,350 --> 00:27:52,660
+تلاتةلغاية اليوم فوق ال 400 different monoclonal
+
+359
+00:27:52,660 --> 00:27:56,160
+antibodies that are being used فبالتالي فينا فوق
+
+360
+00:27:56,160 --> 00:28:03,800
+ال 400 different CD ممكن نحكي فيهم فى ما إيش هنا
+
+361
+00:28:03,800 --> 00:28:09,080
+immuno حطوا كلمة immuno لإنه بنستخدم monoclonal
+
+362
+00:28:09,080 --> 00:28:14,400
+antibody antibody يعني مناعة فينه typing فينه يعني
+
+363
+00:28:14,400 --> 00:28:23,540
+سطحtyping تسمية أو typing من
+
+364
+00:28:23,540 --> 00:28:30,860
+type يعني النوع typing يعني نفحص
+
+365
+00:28:30,860 --> 00:28:38,920
+النوع اللي موجود ماشي immunophenotyping طيب هذا
+
+366
+00:28:38,920 --> 00:28:42,920
+النوع الأولاني ال nutrition حصلت على مستوى مبكر
+
+367
+00:28:42,920 --> 00:28:47,370
+جدا من ال maturation وبالتاليلسة الـ Primary
+
+368
+00:28:47,370 --> 00:28:51,390
+Granules لم تتكون بعد أو لسة في طريقة فبدأوا
+
+369
+00:28:51,390 --> 00:28:57,210
+يبحثوا على الـ Myeloproxidase in trace amount اللي
+
+370
+00:28:57,210 --> 00:29:02,470
+موجود in trace amount في الخلية ودرسوا إيش موجود
+
+371
+00:29:02,470 --> 00:29:06,830
+على سطح الخلية من الإيش من الموليكيول وميزوا هذه
+
+372
+00:29:06,830 --> 00:29:13,900
+الخلايا بهذا النوع سموه M0 ثم M1الأم واحد هي عبارة
+
+373
+00:29:13,900 --> 00:29:17,660
+عن الخلايا الـ acute myelogenous leukemia اللي
+
+374
+00:29:17,660 --> 00:29:20,940
+without maturation كل الخلايا بتكون mono morphic
+
+375
+00:29:20,940 --> 00:29:25,080
+الشو بيسموها mono يعني أحدى morphic الشكل أحدية
+
+376
+00:29:25,080 --> 00:29:29,680
+الشكل بيكون فيه طبعا ال blast موجودة with one or
+
+377
+00:29:29,680 --> 00:29:34,580
+more distinct nuclei الأوروذ body occasionally
+
+378
+00:29:34,580 --> 00:29:40,310
+seen تقريباالـ Primary Grants تكونت لكن بالنسبة
+
+379
+00:29:40,310 --> 00:29:43,410
+للتلاتة في المية المييلة بالريكزيديز الوزياتيتي
+
+380
+00:29:43,410 --> 00:29:47,770
+بتكون at least a three percent لساتها برضه مرحلة
+
+381
+00:29:47,770 --> 00:29:54,130
+مبكرة مرحلة التانية او ال M2هي acute myelogenous
+
+382
+00:29:54,130 --> 00:29:57,270
+leukemia with maturation الـ with maturation يعني
+
+383
+00:29:57,270 --> 00:30:01,510
+بدنا نشوف اكتر من مرحلة من مراحل ال maturation
+
+384
+00:30:01,510 --> 00:30:06,890
+steps فنشوف خمسين او اكتر myeloplast و pro
+
+385
+00:30:06,890 --> 00:30:12,410
+myelocyte وبيكون في single or odd body seen لكن
+
+386
+00:30:12,410 --> 00:30:16,050
+بيكون في this plastic this يعني abnormal plastic
+
+387
+00:30:16,050 --> 00:30:22,110
+منتجة myeloid differentiation يعني خلايا myeloid
+
+388
+00:30:22,380 --> 00:30:34,240
+مشوهة ماشي may be present طيب M3 باختصرها ب APL و
+
+389
+00:30:34,240 --> 00:30:38,860
+هي اختصار ل acute promyelocytic leukemia و من
+
+390
+00:30:38,860 --> 00:30:41,960
+الاسم promyelocytes يعني المرحلة اللي بعد ال
+
+391
+00:30:41,960 --> 00:30:46,320
+myeloblast ماشي طبعا الخلية ال dominant في هذه
+
+392
+00:30:46,320 --> 00:30:49,940
+الحالة يعني ال maturation وجه عندها هي ال
+
+393
+00:30:49,940 --> 00:30:53,230
+promyelocytesوفي هذه المرحلة بيكون heavy
+
+394
+00:30:53,230 --> 00:30:57,930
+azorophobic granules يعني primary granules وهذه ال
+
+395
+00:30:57,930 --> 00:31:03,250
+granules بتتكون في الخلية على شكل bundle يعني حزم
+
+396
+00:31:03,250 --> 00:31:08,810
+من ال our root body وجودها confirm the diagnosis
+
+397
+00:31:08,810 --> 00:31:17,490
+بيؤكد التشخيص وفي منها نوعين نوع كبير ماشي لإن
+
+398
+00:31:17,490 --> 00:31:20,430
+الخلية ال bromiocyte احنا بنعرف أنها أكبر من
+
+399
+00:31:20,430 --> 00:31:21,170
+myeloblast
+
+400
+00:31:23,510 --> 00:31:27,950
+والنوع التاني الصغير اللي بيسموه micro granular
+
+401
+00:31:27,950 --> 00:31:34,770
+variant بيسموه M3V النوع الرابع هو acute
+
+402
+00:31:34,770 --> 00:31:41,830
+myelomonoplastic leukemia وهذا النوع زي M2 يعني في
+
+403
+00:31:41,830 --> 00:31:46,750
+differentiation ولكن بنشوف monocyte لأنه
+
+404
+00:31:46,750 --> 00:31:51,180
+monoplasticفبنشوف اكتر من 20% من مونو بلاست
+
+405
+00:31:51,180 --> 00:31:57,860
+وبرومونو سايتس ومونو سايتس خمسة M5 هو acute
+
+406
+00:31:57,860 --> 00:32:05,140
+monoplastic leukemia وقسموها إلى نوعين M5A وM5B ال
+
+407
+00:32:05,140 --> 00:32:10,560
+M5A بيكون فيه اكتر من 80% من مونو بلاست فقط poorly
+
+408
+00:32:10,560 --> 00:32:18,540
+differentiated بيسموها بينما ال M5B بيكون فيها80%
+
+409
+00:32:18,540 --> 00:32:21,720
+فما فوق مونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+410
+00:32:21,720 --> 00:32:22,760
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+411
+00:32:22,760 --> 00:32:26,040
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+412
+00:32:26,040 --> 00:32:26,140
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+413
+00:32:26,140 --> 00:32:36,960
+بلاست ومونو بلاست ومونو بلاست ومونو
+
+414
+00:32:36,960 --> 00:32:43,080
+بلاست
+
+415
+00:32:43,080 --> 00:32:49,260
+ومبزار يعني مش غير منتظم this plastic غير مشوه
+
+416
+00:32:49,260 --> 00:32:54,800
+يعني nucleated RBCs with multi nucleated form
+
+417
+00:32:54,800 --> 00:32:58,860
+بيكون فيه اكتر من nucleus في الخلية RBCs و فيها
+
+418
+00:32:58,860 --> 00:33:03,760
+اكتر من ايش من ال nucleusان سايتو بلازميك برجينج
+
+419
+00:33:03,760 --> 00:33:07,120
+ان سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+420
+00:33:07,120 --> 00:33:10,160
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+421
+00:33:10,160 --> 00:33:12,060
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+422
+00:33:12,060 --> 00:33:14,640
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+423
+00:33:14,640 --> 00:33:16,420
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+424
+00:33:16,420 --> 00:33:19,480
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+425
+00:33:19,480 --> 00:33:27,520
+سايتو بلازميك برجينج ان سايتو بلازميك برجينم7
+
+426
+00:33:27,520 --> 00:33:31,720
+اكيوت ميجا كاريو بلاستيك لوكيميا وطبعا هنا في
+
+427
+00:33:31,720 --> 00:33:35,960
+فيبروسيس الخلية كبيرة و بتموت في ال بولمارو فبتعمل
+
+428
+00:33:35,960 --> 00:33:39,440
+فيبروسيس للبولمارووهي عبارة عن heterogeneous plus
+
+429
+00:33:39,440 --> 00:33:44,020
+population تتميز بوجود cytoplasmic plebs plebs
+
+430
+00:33:44,020 --> 00:33:48,000
+يعني براعم من ال cytoplasm و ال platelet
+
+431
+00:33:48,000 --> 00:33:51,860
+peroxidase activity is positive هذا عبارة عن
+
+432
+00:33:51,860 --> 00:33:56,840
+enzyme هذه عبارة عن السبع أنواع المختلفة اللي ممكن
+
+433
+00:33:56,840 --> 00:34:01,320
+نتعرف عليها في ال non lymphoplastic leukemia او ال
+
+434
+00:34:01,320 --> 00:34:08,040
+acute myelogenous او myeloid leukemiaطبعا من هنا
+
+435
+00:34:08,040 --> 00:34:11,800
+نطالع هو عبارة عن نفس الحكاية اللى توشرحتها بس
+
+436
+00:34:11,800 --> 00:34:16,820
+بنوع من ايش من التفصيل
+
+437
+00:34:16,820 --> 00:34:23,680
+او الفصل بين الأنواع كاتلين في plastic leukemia زى
+
+438
+00:34:23,680 --> 00:34:31,760
+ما اتفقنا قصة يعني عرفوها بإنه هذه this is the
+
+439
+00:34:31,760 --> 00:34:37,430
+most common وين موجودة في الأطفالوالبروجنوز تبعها
+
+440
+00:34:37,430 --> 00:34:41,230
+is best ايش يعني بروجنوز يعني الى ما يقول الي
+
+441
+00:34:41,230 --> 00:34:46,970
+المرض مستقبل المرض is best يعني كويس يعني ممكن
+
+442
+00:34:46,970 --> 00:34:50,850
+يشفى المريض اه ممكن يشفى بكون ال cell size is
+
+443
+00:34:50,850 --> 00:34:54,470
+small fine or clumped homogeneous nuclear
+
+444
+00:34:54,470 --> 00:35:00,030
+chromatin وفي غياب لل او غير مرئية لل nucleoli
+
+445
+00:35:01,190 --> 00:35:07,950
+والشكل النووي هو عادى مرات يكون النوكليا محطمة أو
+
+446
+00:35:07,950 --> 00:35:13,090
+مفهومة سايتو بلازم تسكنت مع اتفاقات تسيطرة
+
+447
+00:35:13,090 --> 00:35:21,850
+بيزوفيليا وفاكولات مختلفةالنوع التاني طبعا most
+
+448
+00:35:21,850 --> 00:35:25,950
+frequent أكيد لينفو بلاستيك لقيمة موجودة في ال
+
+449
+00:35:25,950 --> 00:35:32,310
+adult ال cell size is large و هتروجناس متباينة
+
+450
+00:35:32,310 --> 00:35:35,750
+بيكون فيه variable chromatin a prominent nucleoli
+
+451
+00:35:35,750 --> 00:35:41,670
+نوكلياس is irregular clifting and intended
+
+452
+00:35:41,670 --> 00:35:43,550
+commonly seen
+
+453
+00:35:48,340 --> 00:35:54,320
+بكون abundant يعني زيادة عن الطبيعي في بيزوفيليا
+
+454
+00:35:54,320 --> 00:35:59,700
+لكنها variable و مرات بتكون deep and vacuums are
+
+455
+00:35:59,700 --> 00:36:06,100
+variable وهي الواحد و زي سايم انتوا شايفين الخلية
+
+456
+00:36:06,100 --> 00:36:10,400
+مشققة من عند ال nucleus هداي ال nucleus ماخدة كل
+
+457
+00:36:10,400 --> 00:36:17,330
+حجم الخلية في cytoplasm very scantyقليل هى وهنا
+
+458
+00:36:17,330 --> 00:36:23,110
+قليل جدا وهى مشقوقة القليل homogeneous population
+
+459
+00:36:23,110 --> 00:36:31,110
+of chromatic material nucleus nuclei is indistinct
+
+460
+00:36:31,110 --> 00:36:37,690
+ده هى زى ما انتوا شايفين ماشى و هكذا طبعا purple
+
+461
+00:36:37,690 --> 00:36:43,230
+deep purple and color وهنا فى ال bone marrow اى
+
+462
+00:36:43,230 --> 00:36:46,880
+خلايابارا عن childhood acute lymphoblastic
+
+463
+00:36:46,880 --> 00:36:55,200
+leukemia ماشي it has high nucleocytoplasmic ratio
+
+464
+00:36:55,200 --> 00:36:59,140
+ايش يعني high nucleus to cytoplasmic ratio نسبة ال
+
+465
+00:36:59,140 --> 00:37:02,520
+nucleus مع ال nucleus محدد كله للخليل فالcytoplasm
+
+466
+00:37:02,520 --> 00:37:06,740
+نسبته قليلة و ال nucleus نسبتها كبيرة فال ratio
+
+467
+00:37:06,740 --> 00:37:09,660
+بتكون عالية ال ratio يعيش بتكون عالي
+
+468
+00:37:13,710 --> 00:37:18,290
+طبعا هنا زى ما انتوا شايفين امينوفينو تايبن كمان
+
+469
+00:37:18,290 --> 00:37:23,270
+بتاخد اذا بيشتغل كيميك سيل وير بي لينيش بي يعني من
+
+470
+00:37:23,270 --> 00:37:31,430
+نوع ال بي وعلى سطحه CD10 CD10 ماشي هذا امينوفينو
+
+471
+00:37:31,430 --> 00:37:36,190
+تايبن هى الاتنين هى الست سايتوم لازم كتر شوية
+
+472
+00:37:38,060 --> 00:37:41,820
+النوكليوس لازالت ماخدة حجم كبير من الخلية لكن فيه
+
+473
+00:37:41,820 --> 00:37:46,600
+تباين في الحجم هي هذه خلية صغيرة هذه اكبر اكبر
+
+474
+00:37:46,600 --> 00:37:54,600
+ماشي نوكليولا is not seen indistinct و مافيش اورد
+
+475
+00:37:54,600 --> 00:38:02,140
+body و still nucleus is verbal و هي ال nucleus
+
+476
+00:38:02,140 --> 00:38:04,920
+اللي قلته في البرمر
+
+477
+00:38:09,640 --> 00:38:13,980
+وقبل تلاتة اتفقنا على ان هي عبارة عن the largest
+
+478
+00:38:13,980 --> 00:38:20,200
+the rarest و largest type of acute lymphoblastic
+
+479
+00:38:20,200 --> 00:38:24,080
+leukemia، sizes large، فيه fine chromatin،
+
+480
+00:38:24,080 --> 00:38:26,900
+homogeneous nuclear chromatin material، فيه
+
+481
+00:38:26,900 --> 00:38:33,220
+prominent nuclei، nucleus is irregular over or
+
+482
+00:38:33,220 --> 00:38:39,480
+around، والcytoplasm is moderately abundant،و
+
+483
+00:38:39,480 --> 00:38:43,520
+بيكون deeply basophilic and vaculated و هي هذا هو
+
+484
+00:38:43,520 --> 00:38:46,280
+زي ما انتوا شايفين ال vacuoles بس مش واضحانة صغيرة
+
+485
+00:38:46,280 --> 00:38:49,720
+ماشي فى vacuoles فى ال cytoplasm فى نيوكليو
+
+486
+00:38:49,720 --> 00:38:56,400
+لعيداية prominent ماشي و هكذا شايفين لأول مرة و
+
+487
+00:38:56,400 --> 00:39:00,460
+كيف واضح ال vaculation فى ال cytoplasm تماما واضح
+
+488
+00:39:04,710 --> 00:39:07,490
+على الـ Incidence بتاعة الـ Acute Lymphoblastic
+
+489
+00:39:07,490 --> 00:39:12,010
+Leukemia جالو يصيب الأطفال من سنين لخمسة لكن برضه
+
+490
+00:39:12,010 --> 00:39:15,990
+ممكن نشوفها في الـ Adult الـ Clinical Finding في
+
+491
+00:39:15,990 --> 00:39:21,010
+Pancytopemia وفي Fatigue وPellor وFever و Weight
+
+492
+00:39:21,010 --> 00:39:25,290
+Loss و Irritability, Anorexia, Infection, Bleeding
+
+493
+00:39:25,290 --> 00:39:29,150
+and Bone Marrow ال Pancytopemia يعني إيش
+
+494
+00:39:29,150 --> 00:39:34,250
+Pancytopemia؟ Pan يعني كل أنواع الخلايا is reduced
+
+495
+00:39:34,770 --> 00:39:41,710
+ساعته خلية وبينيا قلة طبعا بالاضافة إلى ذلك فيه ال
+
+496
+00:39:41,710 --> 00:39:45,650
+signs of anemia fatigue و pallor وفيه signs of
+
+497
+00:39:45,650 --> 00:39:52,910
+infection fever وفيه weight loss لأن ال metabolic
+
+498
+00:39:52,910 --> 00:39:56,550
+rate بتكون عالية جدا وواحد من هالنوع بيكون
+
+499
+00:39:56,550 --> 00:40:02,840
+irritableوهو بيفقد شعيته انوركسيا وفي عنده
+
+500
+00:40:02,840 --> 00:40:08,360
+infection و bleeding وممكن bone pain قال واحد
+
+501
+00:40:08,360 --> 00:40:11,420
+بنشوفه في الأطفال قال اتنين بنشوفه في ال adults
+
+502
+00:40:11,420 --> 00:40:18,880
+قال تلاتة بيسموها Perkits leukemia بيقول موزيز
+
+503
+00:40:18,880 --> 00:40:26,020
+يعني ال ageمهم و ال white blood cell count مهم و
+
+504
+00:40:26,020 --> 00:40:30,580
+cell type هم او يعني they are the most important
+
+505
+00:40:30,580 --> 00:40:34,120
+prognostic indicator هم ال prognostic أيش
+
+506
+00:40:34,120 --> 00:40:39,900
+indicator فجعل المريض البرضة اللي عمرهم اقل من سنة
+
+507
+00:40:39,900 --> 00:40:47,200
+و اكتر من تلتاشر سنة عندهم poor prognosis لكن اذا
+
+508
+00:40:47,200 --> 00:40:50,840
+ال white blood cell count اقل من عشر تلاف عند
+
+509
+00:40:50,840 --> 00:40:51,460
+التشخيص
+
+510
+00:40:59,450 --> 00:41:05,210
+التاسل نوع التالت من الخلايا السبب التالت او
+
+511
+00:41:05,210 --> 00:41:10,630
+الكريتيريا التالتة التاسل اكيوتلينفابلاستيكلوكينة
+
+512
+00:41:10,630 --> 00:41:17,070
+نشوفها كتير في ال male ويلها poor prognosis بينما
+
+513
+00:41:17,070 --> 00:41:23,950
+ال dieselهذا الـ Q-rate يشفي منها المريض وتوصل
+
+514
+00:41:23,950 --> 00:41:31,290
+نسبة الشفاء إلى 70% طبعا
+
+515
+00:41:31,290 --> 00:41:34,090
+هذا ما يتعلق بالـ acute lymphoblastic leukemia الا
+
+516
+00:41:34,090 --> 00:41:37,430
+الـ acute myeloid leukemia برضه نشوفها بيسموها
+
+517
+00:41:37,430 --> 00:41:41,690
+acute granulocytic leukemia و ال classification
+
+518
+00:41:41,690 --> 00:41:48,770
+بيعتمد على البودماروبلاست morphology و
+
+519
+00:41:53,380 --> 00:41:58,800
+نقف هنا نقف
+
+520
+00:41:58,800 --> 00:42:03,900
+هنا ناخد استراحة و نكمل ان شاء الله لحظة
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ca8f9167bdcca6821eb016f11e976424d0107f34
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/iSa5bcNBALs_raw.srt
@@ -0,0 +1,2140 @@
+1
+00:00:02,530 --> 00:00:07,510
+بسم الله الرحمن الرحيم محاضراتنا اليوم ان شاء الله
+
+2
+00:00:07,510 --> 00:00:09,990
+هتكون عن أول نوع من انواع ال hemopoietic
+
+3
+00:00:09,990 --> 00:00:14,830
+malignancy وهو ال acute leukemia وتعريفا ال acute
+
+4
+00:00:14,830 --> 00:00:18,170
+leukemia هي عبارة عن مجموعة متباينة من ال
+
+5
+00:00:18,170 --> 00:00:24,190
+malignant disorders تتميز ب uncontrolled clonal
+
+6
+00:00:24,190 --> 00:00:26,530
+proliferation and accumulation
+
+7
+00:00:30,950 --> 00:00:36,950
+وين في الـ bone marrow and other tissues الان
+
+8
+00:00:36,950 --> 00:00:41,130
+هنشوفها يبقى التعريف خبران heterogeneous group of
+
+9
+00:00:41,130 --> 00:00:44,370
+malignant disorders characterized by uncontrolled
+
+10
+00:00:44,370 --> 00:00:47,530
+clonal proliferation differentiation of
+
+11
+00:00:47,530 --> 00:00:51,890
+accumulation of poorly differentiated blood cellin
+
+12
+00:00:51,890 --> 00:00:54,910
+bone marrow and other tissue شو اللي بيصير ده اللي
+
+13
+00:00:54,910 --> 00:00:57,170
+بيصير في replacement of normal bone marrow
+
+14
+00:00:57,170 --> 00:01:01,830
+elements يعني خلايا ال bone marrow بيصير لها إحلال
+
+15
+00:01:01,830 --> 00:01:08,450
+by abnormal أو سمناها neoplastic أو سمناها
+
+16
+00:01:08,450 --> 00:01:16,010
+leukemic cell اللي ال leukemic cell غالبا بنشوفها
+
+17
+00:01:16,010 --> 00:01:20,410
+بس مش is not always بنشوفها في ال peripheral blood
+
+18
+00:01:20,410 --> 00:01:20,870
+stream
+
+19
+00:01:23,840 --> 00:01:27,940
+وبالتالي بيحصل في الـ leukocytosis في الـ
+
+20
+00:01:27,940 --> 00:01:34,500
+peripheral blood stream لكن ليس دائما ووجودها في
+
+21
+00:01:34,500 --> 00:01:38,740
+الـ peripheral blood smear كإن ماتور كإن ماتور
+
+22
+00:01:38,740 --> 00:01:46,220
+cell or leukemic blast cell هو دليل على ما يسمى
+
+23
+00:01:46,220 --> 00:01:50,780
+بالـ bone marrow failure لأنه صار في إحلاللمعظم
+
+24
+00:01:50,780 --> 00:01:54,240
+خلايا البولمارو زادت في البولمارو فنزلت على ال
+
+25
+00:01:54,240 --> 00:01:57,240
+peripheral blood قال لأ قضية ال بولمارو failure
+
+26
+00:01:57,240 --> 00:02:01,540
+أول ما نذكر هذا المصطلح بدك تعرف ان المريل بدأ
+
+27
+00:02:01,540 --> 00:02:05,720
+يعاني من واحدة او اكتر من واحدة من ..شو بيبصيل؟
+
+28
+00:02:05,720 --> 00:02:10,300
+أنيميالأن الـ leukemic cell حلت محل ال RBCs
+
+29
+00:02:10,300 --> 00:02:14,920
+نيوتروبينيا يعني infection لأنه أيضًا ال leukemic
+
+30
+00:02:14,920 --> 00:02:17,240
+cell حلت محل ال normal neutrophil
+
+31
+00:02:17,240 --> 00:02:21,480
+أنتروبوساتروبينيا أيضًا ال leukemic cell حلت محل
+
+32
+00:02:21,480 --> 00:02:25,120
+ال platelets أو ال thrombocytes أو ال
+
+33
+00:02:25,120 --> 00:02:30,560
+megakaryocytes اللي موجودة في ال bone marrow هذه
+
+34
+00:02:30,560 --> 00:02:35,040
+هي الصورة الكاملة ليش لل leukemic أو لل acute
+
+35
+00:02:35,040 --> 00:02:43,580
+leukemiaاللأ في صفة تالتة يبقى الصفة الأولى غالبا
+
+36
+00:02:43,580 --> 00:02:47,260
+بيصير فيه اما choose self في ال peripheral blood
+
+37
+00:02:47,260 --> 00:02:50,520
+صفة تانيةبيصير فيه bone marrow failure يعني أنيميا
+
+38
+00:02:50,520 --> 00:02:53,580
+نيتروبيليا ثرومبوسايتوبيليا الصفة التالتة بيصير
+
+39
+00:02:53,580 --> 00:02:59,720
+فيه invading for other tissue أشهر هذه ال tissue
+
+40
+00:02:59,720 --> 00:03:03,240
+اللي بتغزوها القلية السرطانية هي reticulum
+
+41
+00:03:03,240 --> 00:03:07,180
+endothelial system ومتمثلة بال spleen و liver و
+
+42
+00:03:07,180 --> 00:03:15,010
+lymph nodes لكن هذا لا يستثني غزوها لأعضاءأخرى من
+
+43
+00:03:15,010 --> 00:03:19,070
+الجسم فممكن تصل إلى أي منطقة من مناطق الجسم لأن
+
+44
+00:03:19,070 --> 00:03:24,070
+الدم بيصل لكل مناطق الجسم وتعشش في أي مكان من
+
+45
+00:03:24,070 --> 00:03:30,850
+الماكن وبالتالي بتكون ماليجنانسي في هذا المكان على
+
+46
+00:03:30,850 --> 00:03:35,570
+if left untreated هذا المرض اذا ما علجنا
+
+47
+00:03:35,570 --> 00:03:37,690
+الليوكيميا eventually causes this
+
+48
+00:03:44,400 --> 00:03:47,480
+هذه الصفات العامة انا قلت لك طبعا الكل كنت تعرفوا
+
+49
+00:03:47,480 --> 00:03:52,300
+ان هذه هي الـ hemopoietic tree لكي ننسى ان ال stem
+
+50
+00:03:52,300 --> 00:03:55,820
+cell تقسم و بتدينا lymphoid و myeloid و ال
+
+51
+00:03:55,820 --> 00:03:58,480
+lymphoid بتدينا ال بي و ال تي lymphocyte و ال
+
+52
+00:03:58,480 --> 00:04:00,900
+myeloid بتدينا كل ال other cell معاها ال
+
+53
+00:04:00,900 --> 00:04:06,180
+lymphocytes اللي في ال acute leukemia اذا انضربت
+
+54
+00:04:06,180 --> 00:04:12,140
+الذراع ال lymphoid progenitor cell بالمحصة اللي هو
+
+55
+00:04:12,140 --> 00:04:17,810
+acute lymphoplastic leukemiaوإذا ضرب ذراع الـ
+
+56
+00:04:17,810 --> 00:04:21,730
+Myeloid Progenitor Cell المحصلة هي Acute
+
+57
+00:04:21,730 --> 00:04:26,690
+Myelogenous Leukemia أو Myeloid Leukemia الـ
+
+58
+00:04:26,690 --> 00:04:31,470
+Myeloid Matureation للتذكير
+
+59
+00:04:31,470 --> 00:04:35,390
+بيتكون من Myeloplast 6 different stages
+
+60
+00:04:35,390 --> 00:04:38,450
+Myeloplast, Promyelocyte, Myelocyte,
+
+61
+00:04:38,530 --> 00:04:41,990
+Metamyelocyte, Band and Utrophil كل المراحل
+
+62
+00:04:41,990 --> 00:04:47,680
+الأولانية هي عبارة عن Mature Formوبالتالي ممكن
+
+63
+00:04:47,680 --> 00:04:51,580
+يصير فيه وقف لـ maturation في أي مرحلة من المراحل
+
+64
+00:04:51,580 --> 00:04:56,960
+المبكرة يعني الـ immature البدري هذه الأشكال
+
+65
+00:04:56,960 --> 00:05:04,640
+المختلفة ليش ليه هذه الخلايا ال .. في الاكيد الـ
+
+66
+00:05:04,640 --> 00:05:07,700
+GMF يصير في accumulation of blast in the marrow و
+
+67
+00:05:07,700 --> 00:05:09,840
+هذا شكل ال blast زي ما .. زي ما انتوا شايفين هي
+
+68
+00:05:09,840 --> 00:05:14,750
+عبارة عن abnormal cell كبيرةالنيوكلياس ماخدة حجم
+
+69
+00:05:14,750 --> 00:05:18,630
+كبير من الخلية ال .. اللي .. من ال .. اه من الخلية
+
+70
+00:05:18,630 --> 00:05:22,730
+و الـ cytoplasm is .. is .. is .. is a rim or is
+
+71
+00:05:22,730 --> 00:05:31,910
+slightly decreased ماشي لونها still blue to purple
+
+72
+00:05:31,910 --> 00:05:37,010
+in color لأن كل ما تطورت الخلية كل ما اتغير لونها
+
+73
+00:05:37,010 --> 00:05:39,470
+و هذه اللون الأزرق اللي هو عبارة عن sign of
+
+74
+00:05:39,470 --> 00:05:44,520
+maturity و في نيوكليو like نيوكلياسوإن كانت غير
+
+75
+00:05:44,520 --> 00:05:50,480
+واضحة تماما لكن it's huge وليسين اتفقنا على ان ال
+
+76
+00:05:50,480 --> 00:05:53,080
+borne marrow failure بيصير فيه neutropenia
+
+77
+00:05:53,080 --> 00:05:57,180
+ومحصلتها infection وsepsis لإنه ال neutrophil هي
+
+78
+00:05:57,180 --> 00:06:02,200
+عبارة عن phagocytic cell يعني it phagocytized the
+
+79
+00:06:02,200 --> 00:06:05,580
+antigen ماصارش .. مافيش neutrophil مافيش
+
+80
+00:06:05,580 --> 00:06:10,440
+phagocytosis يعني فيه infection أنيميا general
+
+81
+00:06:10,440 --> 00:06:14,050
+characteristics للأنيميا الفتيق والبلرand
+
+82
+00:06:14,050 --> 00:06:19,330
+thrombocytopenia يعني فيه bleeding ال incidence of
+
+83
+00:06:19,330 --> 00:06:24,110
+leukemia دي طبعا إحصائية قديمة لكنها لازالت معتمدة
+
+84
+00:06:24,110 --> 00:06:28,650
+لأنه زي ما انتوا شايفين احنا اتفقنا على انه ال
+
+85
+00:06:28,650 --> 00:06:35,590
+acute بتمثل 50% من أنواع ال leukemia فهي ال acute
+
+86
+00:06:35,590 --> 00:06:43,530
+lymphoplastic 11و الـ acute myelogenous 31 11 و 31
+
+87
+00:06:43,530 --> 00:06:54,070
+يعني 42 و ال economic برضه 50% اي 26 CLL و 15% CML
+
+88
+00:06:54,070 --> 00:06:56,750
+الاتنين بشكل 41%
+
+89
+00:06:59,600 --> 00:07:07,020
+42 تقريبا و ال acute
+
+90
+00:07:07,020 --> 00:07:10,720
+leukemia بأنواعها 42 و ال chronic leukemia
+
+91
+00:07:10,720 --> 00:07:15,800
+بأنواعها 41 تقريبا جابعة الباقي هو عبارة عن other
+
+92
+00:07:15,800 --> 00:07:23,820
+types of leukemia طيب نجي نشوف شو بيعمل شو بتعمل
+
+93
+00:07:23,820 --> 00:07:29,620
+ال acute leukemia في الجسمقالوا أولا اليكنوجينيسيز
+
+94
+00:07:29,620 --> 00:07:32,780
+بينتج نتيجة genetic alteration within a single
+
+95
+00:07:32,780 --> 00:07:36,060
+stem cell يعني الخلل بيصير على مستوى ال stem cell
+
+96
+00:07:36,060 --> 00:07:40,180
+على مستوى ال stem cell شو بيصير؟ قالوا بيصير فيه
+
+97
+00:07:40,180 --> 00:07:44,360
+خلل في الجينات وعندنا عرفنا الخلل ممكن يكون واحد
+
+98
+00:07:44,360 --> 00:07:48,020
+من أربع أنواع من الخلل اللي ذكرناهم في المحاضرة
+
+99
+00:07:48,020 --> 00:07:53,510
+السابقةماذا يفعل هذا؟ قالوا ماذا يحصل فيه؟ او ماهي
+
+100
+00:07:53,510 --> 00:07:57,070
+نتيجة هذا الـ mutation اللي حصلت؟ قالوا بيحصل فيه
+
+101
+00:07:57,070 --> 00:08:00,570
+blockage في ال maturation at certain level و يوم
+
+102
+00:08:00,570 --> 00:08:04,890
+بيحصل فيه mutation عند هبقى في ال maturation و عند
+
+103
+00:08:04,890 --> 00:08:10,990
+هذه الخلية بيحصل فيه اللي هو زيادة في هذه الخلية
+
+104
+00:08:10,990 --> 00:08:14,990
+لأن الخلية تنقص و تصل هذه المرحلة تنقص و تصل هذه
+
+105
+00:08:14,990 --> 00:08:20,800
+المرحلةماشي طب بعد هيك مافيش امكانية which means
+
+106
+00:08:20,800 --> 00:08:23,500
+انه في abnormal regulatory mechanism مافي امكانية
+
+107
+00:08:23,500 --> 00:08:27,960
+ان يصير في regulation للميكانيزم و يكمل للاخر
+
+108
+00:08:27,960 --> 00:08:32,940
+وبالتالي الخلية غير قادرة على any further
+
+109
+00:08:32,940 --> 00:08:36,260
+proliferation and differentiation لكنها لازالت
+
+110
+00:08:36,260 --> 00:08:41,010
+تنقسم لازالت استطيع ان تنقسمأيه بجاش اللي صار
+
+111
+00:08:41,010 --> 00:08:44,490
+قالوا على مستوى ال stem cell صار فيه genetic
+
+112
+00:08:44,490 --> 00:08:48,790
+mutation عملت blockage في ال maturation وبالتالي
+
+113
+00:08:48,790 --> 00:08:51,110
+الخلية there is no more proliferation and
+
+114
+00:08:51,110 --> 00:08:54,170
+differentiation but still it has the ability to
+
+115
+00:08:54,170 --> 00:08:58,270
+divide ال division successive mitotic division
+
+116
+00:08:58,270 --> 00:09:03,700
+continuous division يعنيفي الخلايا الغير نادجة
+
+117
+00:09:03,700 --> 00:09:09,340
+بيؤدي الى production of clonal population ايش يعني
+
+118
+00:09:09,340 --> 00:09:16,700
+clonal يعني خلايا منه واحد ماشي clonal population
+
+119
+00:09:16,700 --> 00:09:23,680
+which once it's sufficient يوم ما يصير كافي ماشي
+
+120
+00:09:23,680 --> 00:09:30,000
+يزيد a clonal mass بيبدأ تتكون mass has been
+
+121
+00:09:30,000 --> 00:09:34,490
+achievedهذه الاختصارات بتؤدي إلى الـ Clinical
+
+122
+00:09:34,490 --> 00:09:39,210
+Manifestation of Disease إذا باختصار هو عبارة عن
+
+123
+00:09:39,210 --> 00:09:42,920
+Mutation على مستوى الـ Stem Cellوهذه الـ mutation
+
+124
+00:09:42,920 --> 00:09:46,120
+قامت بـ blockage في الـ maturation بطلت الخلية
+
+125
+00:09:46,120 --> 00:09:49,680
+قادرة على any proliferation and differentiation
+
+126
+00:09:49,680 --> 00:09:53,740
+لكنها still has the ability to divide وبالتالي
+
+127
+00:09:53,740 --> 00:09:58,400
+continuous division للخلية هيأدى إلى تكوين mass of
+
+128
+00:09:58,400 --> 00:10:03,160
+the same cell سموها clonal population اي cell اللى
+
+129
+00:10:03,160 --> 00:10:07,120
+وجبت عندها ال maturation طبعا هذه ال mass هي اللى
+
+130
+00:10:07,120 --> 00:10:10,480
+بتعمل ال clinical manifestation of the disease
+
+131
+00:10:14,890 --> 00:10:19,290
+فسّروا أو لخصوا الـ Echogenesis الـ Echogenesis
+
+132
+00:10:19,290 --> 00:10:22,710
+اللي هو لخصوه بحاجتين يعني بيصير فيه loss of
+
+133
+00:10:22,710 --> 00:10:27,250
+function لـ transcriptional factor من خلالها فقدنا
+
+134
+00:10:27,250 --> 00:10:30,190
+ال differentiation وبالتالي الخلية لا تستطيع أن
+
+135
+00:10:30,190 --> 00:10:35,370
+تتميز anymore وبالتالي صار في خلال فيه في اللي هو
+
+136
+00:10:35,370 --> 00:10:38,630
+certain transcriptional factor ماشي وفيه
+
+137
+00:10:38,630 --> 00:10:42,770
+transcriptional factor خاصة التي تتعلق بالـ
+
+138
+00:10:42,770 --> 00:10:46,730
+differentiationوهو في نفس الوقت بيحصل فيه gain of
+
+139
+00:10:46,730 --> 00:10:51,970
+function gain of function من ال limitation اه شو
+
+140
+00:10:51,970 --> 00:10:57,010
+بيحصل؟ قالوا بيحصل تانيزين كينيزيز تتنشط و برضه
+
+141
+00:10:57,010 --> 00:11:02,090
+هذه تتعلق بال transcriptional factor الخاص بال
+
+142
+00:11:02,090 --> 00:11:05,210
+proliferation فبالتالي مافيش differentiation لكن
+
+143
+00:11:05,210 --> 00:11:10,050
+في proliferation هذه هي ال acute leukemia
+
+144
+00:11:12,920 --> 00:11:17,540
+by animation المرأة اللي بتمر فيها اللي أكيد له
+
+145
+00:11:17,540 --> 00:11:21,180
+كيميا جاله هذه صورة لأول مرحلة هي state number one
+
+146
+00:11:21,180 --> 00:11:25,040
+وهي ال normal هي في خلايا white في خلايا RBC في
+
+147
+00:11:25,040 --> 00:11:31,000
+Platelet طبعا هي ال white وهي ال RBC وهي ال
+
+148
+00:11:31,000 --> 00:11:35,580
+Platelet واحدة أصغر من الثانية اللي في state
+
+149
+00:11:35,580 --> 00:11:39,600
+number two صار في symptoms لا أعرف ليش جاله لإنه
+
+150
+00:11:39,600 --> 00:11:45,270
+انضربتالـ White Blood Cell بدأ يحلل للـ Normal
+
+151
+00:11:45,270 --> 00:11:50,110
+White Blood Cell الـ White Blood Cell بدأ يحلل للـ
+
+152
+00:11:50,110 --> 00:11:50,110
+Normal White Blood Cell الـ White Blood Cell بدأ
+
+153
+00:11:50,110 --> 00:11:50,110
+يحلل للـ Normal White Blood Cell الـ White Blood
+
+154
+00:11:50,110 --> 00:11:50,970
+Cell بدأ يحلل للـ Normal White Blood Cell الـ
+
+155
+00:11:50,970 --> 00:11:50,990
+White Blood Cell بدأ يحلل للـ Normal White Blood
+
+156
+00:11:50,990 --> 00:11:51,150
+Cell الـ White Blood Cell بدأ يحلل للـ Normal
+
+157
+00:11:51,150 --> 00:11:51,150
+White Blood Cell الـ White Blood Cell بدأ يحلل للـ
+
+158
+00:11:51,150 --> 00:11:51,150
+Normal White Blood Cell الـ White Blood Cell بدأ
+
+159
+00:11:51,150 --> 00:11:51,150
+يحلل للـ Normal White Blood Cell الـ White Blood
+
+160
+00:11:51,150 --> 00:11:51,150
+Cell بدأ يحلل للـ Normal White Blood Cell الـ
+
+161
+00:11:51,150 --> 00:11:51,150
+White Blood Cell بدأ يحلل للـ Normal White Blood
+
+162
+00:11:51,150 --> 00:11:51,150
+Cell الـ White Blood Cell بدأ يحلل للـ Normal
+
+163
+00:11:51,150 --> 00:11:51,230
+White Blood Cell الـ White Blood Cell بدأ يحلل للـ
+
+164
+00:11:51,230 --> 00:11:52,410
+Normal White Blood Cell الـ White Blood Cell بدأ
+
+165
+00:11:52,410 --> 00:11:54,080
+يحلل للـ Normal White Blood Cell الـ Whiteو ال
+
+166
+00:11:54,080 --> 00:12:01,020
+blood stream وبالتالي صار في ايش؟ صار في symptoms
+
+167
+00:12:01,020 --> 00:12:04,720
+رحلة تالتة طبعا diagnosis لما كل الخلايا الواقعة
+
+168
+00:12:04,720 --> 00:12:09,220
+blood cell تصير عبارة عن abnormal عبارة عن blast
+
+169
+00:12:09,220 --> 00:12:13,200
+او leukemic cell وبالتالي المريض بده يعانى في هذه
+
+170
+00:12:13,200 --> 00:12:19,300
+الحالة من اما يعني بده يعانى من infection مافيش
+
+171
+00:12:19,300 --> 00:12:23,840
+neutrophil مافيش infectionيعني at least بديه يعانى
+
+172
+00:12:23,840 --> 00:12:28,040
+من infection لكن ممكن يعانى من other conditions زي
+
+173
+00:12:28,040 --> 00:12:30,940
+الانيميا وThrombocytopenia يعني بأنه جث ينخش
+
+174
+00:12:30,940 --> 00:12:35,540
+المريض في bone marrow failure طبعا
+
+175
+00:12:35,540 --> 00:12:38,480
+stage number four بيصير فيه worsening للحالة
+
+176
+00:12:38,480 --> 00:12:42,120
+الانيميا صارت more severe ثرمبوcytopenia برضه كتير
+
+177
+00:12:42,120 --> 00:12:45,480
+مافيش platelet يعني وكل وقت blood cell هي عبارة عن
+
+178
+00:12:45,480 --> 00:12:50,010
+leukemic cellطبعا في المرحلة الأخيرة زي ما اتفقنا
+
+179
+00:12:50,010 --> 00:12:53,950
+stage number five a او b اما المريض يعاني من
+
+180
+00:12:53,950 --> 00:12:58,250
+أنيميا مافيش ولا ور بي سين زي ما انتوا شايفين واما
+
+181
+00:12:58,250 --> 00:13:03,330
+يعاني من infection وبالتالي هي أسباب التشخيص
+
+182
+00:13:03,330 --> 00:13:08,570
+للمريض لأنه متى ما بدأ المريض يعاني ببدأ ي .. يعني
+
+183
+00:13:08,570 --> 00:13:14,170
+يروح على الدكتور ويتشخص laboratory evaluation
+
+184
+00:13:15,030 --> 00:13:21,130
+التشخيص بيعتمد على حاجتين أساسيات كانوا نمرة واحد
+
+185
+00:13:21,130 --> 00:13:26,430
+زيادة مضردة في الـ Immature cells في البونمارو بما
+
+186
+00:13:26,430 --> 00:13:32,070
+فيها البلاست والبروميلوسايز والبرومونوسايز كلها
+
+187
+00:13:32,070 --> 00:13:36,790
+Pro يعني Immature وشرط أساسي لازم يزيد عددها عن
+
+188
+00:13:36,790 --> 00:13:42,530
+تلاتين في المية من البونمارو elements يبقى أول
+
+189
+00:13:42,530 --> 00:13:47,720
+حاجة زيادةفي عدد الـ Immature cells في البون مارو
+
+190
+00:13:47,720 --> 00:13:50,920
+بمعدل
+
+191
+00:13:50,920 --> 00:13:58,140
+30% فما فوق من خلايا البون مارو لما تنين بدنا نحدد
+
+192
+00:13:58,140 --> 00:14:01,640
+ال cell lineage يعني أي نوع من الخلايا اللي انضرب
+
+193
+00:14:01,640 --> 00:14:06,400
+وبالتالي ما هي نوع ال leukemic cell اللي موجودة
+
+194
+00:14:06,400 --> 00:14:09,760
+يبقى التشخيص بيعتمد على حاجتين الحاجة الأولى هي
+
+195
+00:14:09,760 --> 00:14:13,040
+نوع الخلية المصعبة
+
+196
+00:14:14,240 --> 00:14:19,320
+وعشان نسمي اللوكيميا باسمها يعني لو lymphoid بدنا
+
+197
+00:14:19,320 --> 00:14:22,280
+نقول acute lymphoblastic leukemia و لو myeloid
+
+198
+00:14:22,280 --> 00:14:25,680
+بدنا نقول acute myelogenous leukemia و الحاجة
+
+199
+00:14:25,680 --> 00:14:28,580
+التانية يجب أن يكون عدد ال immature cell في ال
+
+200
+00:14:28,580 --> 00:14:34,100
+bone marrow أكتر من 30% هذا هو تعريف اللوكيميا
+
+201
+00:14:34,100 --> 00:14:37,680
+اللي في الـ peripheral blood بيكون فيه أنيميا
+
+202
+00:14:37,680 --> 00:14:40,480
+والأنيميا في كل أنواع اللوكيميا هي normocytic
+
+203
+00:14:40,480 --> 00:14:45,090
+normochromicو بيكون فيه decrease في الـ platelet
+
+204
+00:14:45,090 --> 00:14:50,050
+قلة يعني Trombocytopenia بس ما يميز لأكيد
+
+205
+00:14:50,050 --> 00:14:54,470
+اللوكيميا أن ال white blood cell بتكون variable و
+
+206
+00:14:54,470 --> 00:14:59,510
+درجة الوجود
+
+207
+00:14:59,510 --> 00:15:03,350
+ال white blood cell في ال peripheral blood قسموها
+
+208
+00:15:04,040 --> 00:15:07,980
+بناء على عدد او نسبة ال white blood cell في
+
+209
+00:15:07,980 --> 00:15:11,680
+البريفيرال blood تقسم اللوكيميا هذه الأكيدلوكيميا
+
+210
+00:15:11,680 --> 00:15:16,960
+لتلت أنواع جالو اما لوكيميك لوكيميا و بيكون في
+
+211
+00:15:16,960 --> 00:15:23,560
+زيادة في ال white blood cell لأن فيه blast او sub
+
+212
+00:15:23,560 --> 00:15:27,220
+-lokimic لوكيميا وجدوا فيه blast لكن مافيش زيادة
+
+213
+00:15:27,220 --> 00:15:33,090
+في ال white blood cell او E-lokimic لوكيميابكون في
+
+214
+00:15:33,090 --> 00:15:36,830
+قلة في white blood cell and there is no blast لكن
+
+215
+00:15:36,830 --> 00:15:40,150
+still لو فحصت البرنامج بتلاقي فيها اللي هي
+
+216
+00:15:40,150 --> 00:15:44,490
+اللوكيمي او اللوكيميك سيل يبقى according to the
+
+217
+00:15:44,490 --> 00:15:47,330
+presence of اللوكيميك سيل in the peripheral blood
+
+218
+00:15:47,330 --> 00:15:50,370
+قسموا ال acute لوكيمي إلى تلت أنواع لوكيميك
+
+219
+00:15:50,370 --> 00:15:56,570
+وسبلوكيميك وإي لوكيميك ال classification of
+
+220
+00:15:56,570 --> 00:15:58,470
+immature cells
+
+221
+00:16:01,330 --> 00:16:03,950
+كان بيه done by the following نمرا واحد يعني كيف
+
+222
+00:16:03,950 --> 00:16:07,950
+انا بشخص كيف بقول والله هذه عبارة عن image or cell
+
+223
+00:16:07,950 --> 00:16:12,950
+قالوا نمرا واحد هو الأساس هو ال morphology وبده في
+
+224
+00:16:12,950 --> 00:16:15,950
+هذه الحالة ال morphology بده يكون فيه experienced
+
+225
+00:16:15,950 --> 00:16:20,250
+morphologist واحد بيحافظ واحد فاهم واحد مضاهي خصص
+
+226
+00:16:20,720 --> 00:16:25,160
+ماشي يتعرف على إيش؟ جالو يتعرف على الصفات الآتية،
+
+227
+00:16:25,160 --> 00:16:28,200
+نمرة واحد the size of a blast يعني أنا عشان أشخص
+
+228
+00:16:28,200 --> 00:16:31,660
+بدي أدور على الشغلات الآتية، نمرة واحد the size of
+
+229
+00:16:31,660 --> 00:16:35,500
+a blast، نمرة اتنين the amount of cytoplasm، نمرة
+
+230
+00:16:35,500 --> 00:16:39,730
+تلاتة nuclear chromatin patternنمرأة أربعة The
+
+231
+00:16:39,730 --> 00:16:45,150
+Presence of Nucleoli و The Presence of Our Root
+
+232
+00:16:45,150 --> 00:16:49,770
+Body Our Root Body تعريفا هي عبارة عن Pink
+
+233
+00:16:49,770 --> 00:16:55,350
+Staining Splinter Shaped ايش يعني Splinter يعني
+
+234
+00:16:55,350 --> 00:17:00,950
+شغية Splinter Shaped شكل الشغية Inclusion وين
+
+235
+00:17:00,950 --> 00:17:05,250
+موجود؟ على شكل الروت طبعا موجود وين؟ موجود في
+
+236
+00:17:05,250 --> 00:17:11,670
+الـCytoplasmوهو عبارة عن alignment يعني تصفيتها من
+
+237
+00:17:11,670 --> 00:17:15,130
+ال primary granules غالبا بنشوفها في ال
+
+238
+00:17:15,130 --> 00:17:22,030
+myeloproliferative process إذا ما هي الشغلات اللي
+
+239
+00:17:22,030 --> 00:17:26,170
+لازم يدور عليها ال morphologist؟ قولنا خمس شغلات
+
+240
+00:17:26,170 --> 00:17:29,810
+الشغلة الأولى هي ال size of lust الشغلة التانية ال
+
+241
+00:17:29,810 --> 00:17:33,590
+amount of cytoplasm الشغلة التالتة ال nuclear
+
+242
+00:17:33,590 --> 00:17:38,550
+chromatin material أيش أخبار لكروماتين؟نمرة أربعة
+
+243
+00:17:38,550 --> 00:17:42,110
+لـPresence of Nucleolife in Nucleus نمرة خمسة
+
+244
+00:17:42,110 --> 00:17:46,490
+لـPresence of Our Rot Body Presence of Our Rot
+
+245
+00:17:46,490 --> 00:17:50,250
+Body خمس شغلات لازم يدور عليها الـMorphologist من
+
+246
+00:17:50,250 --> 00:17:55,090
+خلالها يستطيع ان يحكم This is a Leukemic or
+
+247
+00:17:55,090 --> 00:18:01,790
+Immature Cell or Not المحصلة
+
+248
+00:18:01,790 --> 00:18:08,370
+انه بتعرف على Myeloblastعلى خلية immature أو
+
+249
+00:18:08,370 --> 00:18:13,990
+المرحلة اللي بعدها لكنها still immature طيب شو شكل
+
+250
+00:18:13,990 --> 00:18:17,210
+ال blast؟ ال myeloblast ده ال myeloblast هي عبارة
+
+251
+00:18:17,210 --> 00:18:24,230
+عن large blast with moderate amount of cytoplasm و
+
+252
+00:18:24,230 --> 00:18:27,950
+بتتميز بوجود fine lacy chromatin لسه ال chromatin
+
+253
+00:18:27,950 --> 00:18:34,510
+is lacy، homogeneousand prominent nuclei وفي ال
+
+254
+00:18:34,510 --> 00:18:42,870
+nucleus نيوكليولاي دائمة و تقريبا 10 ل 40% من ال
+
+255
+00:18:42,870 --> 00:18:47,770
+myeloblast بيحتووا على او نشوف فيهم our root body
+
+256
+00:18:47,770 --> 00:18:54,070
+وهذا هو شكل ال myeloblast زي ما انتوا شايفينه خلية
+
+257
+00:18:54,070 --> 00:18:58,870
+كبيرة لو قرنناها بالاربسيز و طبعا ال nucleus ماخدة
+
+258
+00:18:58,870 --> 00:19:04,540
+حجم كبير من الخلية ساتو بلازم تقريبا اقل بكثير
+
+259
+00:19:04,540 --> 00:19:09,000
+حوالي اقل من التلت والاول رد بضيعي وموجود وفي
+
+260
+00:19:09,000 --> 00:19:12,680
+عندنا اكتر من نيوكليو لاي في الخلف نيوكلياس وبعدين
+
+261
+00:19:12,680 --> 00:19:15,040
+بدنا نشوف على ال chromatic material زي ما انتوا
+
+262
+00:19:15,040 --> 00:19:18,900
+شايفين هي برعنة homogeneous it's not coarse it's
+
+263
+00:19:18,900 --> 00:19:25,100
+soft ماشي طيب
+
+264
+00:19:25,100 --> 00:19:31,600
+نبدأ نشوفتعريف ايضا ال ال ال ال ال ال ال ال ال ال
+
+265
+00:19:31,600 --> 00:19:33,800
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+266
+00:19:33,800 --> 00:19:34,960
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+267
+00:19:34,960 --> 00:19:37,920
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+268
+00:19:37,920 --> 00:19:40,980
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+269
+00:19:40,980 --> 00:19:41,740
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+270
+00:19:41,740 --> 00:19:41,820
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+271
+00:19:41,820 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+272
+00:19:42,480 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+273
+00:19:42,480 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+274
+00:19:42,480 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+275
+00:19:42,480 --> 00:19:42,480
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+276
+00:19:42,480 --> 00:19:42,500
+ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال
+
+277
+00:19:42,500 --> 00:19:45,020
+ال ال
+
+278
+00:19:56,350 --> 00:20:00,410
+and indistinct in nucleoli فى نيكليولاية لكنها غير
+
+279
+00:20:00,410 --> 00:20:04,970
+مرئية مش مشيوفة and there is no our root body طبعا
+
+280
+00:20:04,970 --> 00:20:09,970
+ال our root body فى ال lymphoblast بتنشفش لإنه هي
+
+281
+00:20:09,970 --> 00:20:13,490
+عبارة عن تصفيتها من ال primary granules و ال
+
+282
+00:20:13,490 --> 00:20:19,390
+lymphoblast عبارة عن a granular cell ماشي يبقى فى
+
+283
+00:20:19,390 --> 00:20:22,910
+اختلاف او فى اختلاف و ده هو شكل ال lymphoblast
+
+284
+00:20:22,910 --> 00:20:24,450
+واضح جدا فى الصورة
+
+285
+00:20:27,300 --> 00:20:35,020
+وقسموا اللوكيميا إلى عدة أنواع وعند التقسيمة اجتمع
+
+286
+00:20:35,020 --> 00:20:40,700
+علماء من ال French من فرنسا وامريكا و British
+
+287
+00:20:40,700 --> 00:20:45,700
+Scientists وسموا حالهم ال Fab Group Fab يعني
+
+288
+00:20:45,700 --> 00:20:51,160
+French American British Group and
+
+289
+00:20:51,160 --> 00:20:56,680
+these are experts of hematologist اشتركوا
+
+290
+00:20:57,590 --> 00:21:04,550
+في الـ classification مع بعض واتفقوا على definite
+
+291
+00:21:04,550 --> 00:21:10,510
+criteria for acute classification و acute leukemia
+
+292
+00:21:10,510 --> 00:21:21,040
+كيف عملوا؟ يعني جابوا كل أموال اللوكيمياو بدوا
+
+293
+00:21:21,040 --> 00:21:24,900
+يعدوا يعملوها differential بس بدل ان يعدوا 100
+
+294
+00:21:24,900 --> 00:21:33,260
+خلية كانوا يعدوا 200 خلية و .. يعني double
+
+295
+00:21:33,260 --> 00:21:37,640
+differential و طبعا هم جابوا فيهم 200 نوع من ال
+
+296
+00:21:37,640 --> 00:21:40,960
+leukemia و بدوا يعملوا لكل واحدة differential بس
+
+297
+00:21:40,960 --> 00:21:46,160
+كانوا يعدوا الخلايا 200 و في نفس الوقت يبقى ال
+
+298
+00:21:46,160 --> 00:21:48,560
+morphology في الأول يبقى differential في الأول
+
+299
+00:21:48,960 --> 00:21:51,880
+والحاجة التانية اللي اعتمدوا عليها هو ال .. ال
+
+300
+00:21:51,880 --> 00:21:57,200
+cytochemistry بدوا يستخدموا stain معينة عشان ت
+
+301
+00:21:57,200 --> 00:22:00,080
+distinguish between myeloid و lymphoid فجأة
+
+302
+00:22:00,080 --> 00:22:07,800
+استخدموا ال myeloproxidase و السوداني black و
+
+303
+00:22:07,800 --> 00:22:11,820
+هدولة بدونة positive في الmyeloid و negative في ال
+
+304
+00:22:11,820 --> 00:22:17,420
+lymphoid يبقى المجموعة هذه جاعدت و اشتغلتعملت
+
+305
+00:22:17,420 --> 00:22:22,620
+differential لأكتر من متين نوع من اللوكيميا وعملوا
+
+306
+00:22:22,620 --> 00:22:25,880
+differential و .. صبغوا عملوا differential
+
+307
+00:22:25,880 --> 00:22:31,040
+واشتغلوا cytochemistry يعني specialists تين بال
+
+308
+00:22:31,040 --> 00:22:35,800
+differential كانوا يعدوا 200 خلية و مش واحد يعدها
+
+309
+00:22:35,800 --> 00:22:39,700
+اكتر من واحد لأنه French American British عشان
+
+310
+00:22:39,700 --> 00:22:43,680
+يتأكدوا تماما ان الخلية اللي شافوها هي عبارة عن
+
+311
+00:22:44,240 --> 00:22:51,680
+الخلية المتفق عليها واملولد هو ال cytochemistry او
+
+312
+00:22:51,680 --> 00:22:56,140
+ال specialists تين صبغوا ال myeloprexidase و
+
+313
+00:22:56,140 --> 00:22:59,900
+استخدموا السودان بلاك عشان يميزوا ما بين ال
+
+314
+00:22:59,900 --> 00:23:04,780
+myeloid و ال lymphoidوبناء على ذلك قسموا اللوكيميا
+
+315
+00:23:04,780 --> 00:23:08,340
+للتقسيم اللي احنا شفناها قد الشريع جابليك قالوا
+
+316
+00:23:08,340 --> 00:23:11,300
+فيه acute leukemia و chronic leukemia و هي الفقب
+
+317
+00:23:11,300 --> 00:23:15,660
+myeloid و lymphoid و طلعوا ب8 أنواع myeloid و 3
+
+318
+00:23:15,660 --> 00:23:19,280
+أنواع lymphoid و نفس الحكاية قسموا ل chronic
+
+319
+00:23:19,280 --> 00:23:24,140
+leukemia لكن خلّيني أحكي الآن عن ال acute leukemia
+
+320
+00:23:24,140 --> 00:23:29,880
+و نبدأ نتعرف على أنه الأول و هو ال lymphoid و قلنا
+
+321
+00:23:29,880 --> 00:23:35,010
+ال lymphoid قسموا إلى 3 أنواعو رمزولة ب L lymphoid
+
+322
+00:23:35,010 --> 00:23:41,150
+number واحد و اتنين و تلاتة فجالوا ال L واحد هي
+
+323
+00:23:41,150 --> 00:23:45,790
+عبارة عن خلايا او الخلايا تتميز ب homogenous
+
+324
+00:23:45,790 --> 00:23:49,430
+homogenous يعني كلهم زي بعض population of a small
+
+325
+00:23:49,430 --> 00:23:54,550
+lymphoblast و this lymphoblast has scanty
+
+326
+00:23:54,550 --> 00:23:59,750
+cytoplasm مش فيها cytoplasm and scanty nucleoli ما
+
+327
+00:23:59,750 --> 00:24:06,110
+بتشاهد فيها nucleoliوالـ nucleus occasionally
+
+328
+00:24:06,110 --> 00:24:13,650
+clifted أحياناً يكون فيه شق في الـ nucleus ثم
+
+329
+00:24:13,650 --> 00:24:16,770
+قالتوا كانوا بيقدروا على heterogeneous population
+
+330
+00:24:16,770 --> 00:24:26,530
+يعني population متباين إشي large وإشي small ماشي
+
+331
+00:24:26,530 --> 00:24:28,990
+of large lymphoplast
+
+332
+00:24:31,820 --> 00:24:35,640
+with moderately abundant شوية سايتو بلازم أكتر
+
+333
+00:24:35,640 --> 00:24:41,500
+وفيه نيوكليولهاي أكتر و ال nucleus are commonly
+
+334
+00:24:41,500 --> 00:24:46,360
+intended or eclifted يعني في الحالة بتكون الخلية
+
+335
+00:24:46,360 --> 00:24:52,060
+ال nucleus مشكوقة ثم نوع التالت اللي هو ال تلاتة
+
+336
+00:24:52,060 --> 00:24:56,360
+percates بيسموها percates type وبر انه homogeneous
+
+337
+00:24:56,360 --> 00:25:00,410
+population فقطof large lymphoblast الخلايا بتكون
+
+338
+00:25:00,410 --> 00:25:06,510
+كبيرة فقط with prominent دايما فيها nucleoli و ال
+
+339
+00:25:06,510 --> 00:25:11,350
+cytoplasm هو عبارة عن deeply basophilic and
+
+340
+00:25:11,350 --> 00:25:17,190
+vaculated يعني في vacuoles في ال cytoplasm و
+
+341
+00:25:17,190 --> 00:25:23,910
+بالتالي تلت أنواع سهل متعرف عليها ال myeloid كانوا
+
+342
+00:25:23,910 --> 00:25:28,590
+قسموها إلى تمام أنواعأم زيرو according to the
+
+343
+00:25:28,590 --> 00:25:34,690
+maturation طبعا ام زيرو وفي الام زيرو هي عبارة عن
+
+344
+00:25:34,690 --> 00:25:38,830
+خلايا صارت ال mutation في مرحلة مبكرة جدا جدا جدا
+
+345
+00:25:38,830 --> 00:25:44,050
+لسه ما اتكونت ال .. عاملا بتتكون ال .. ال .. ال
+
+346
+00:25:44,050 --> 00:25:49,350
+primal granules فشخصوها
+
+347
+00:25:49,350 --> 00:25:52,990
+by electron microscopy كيف؟ لأنه دوروا على ال
+
+348
+00:25:52,990 --> 00:25:57,290
+ultra structural myeloproxenase activityيعني
+
+349
+00:25:57,290 --> 00:26:02,230
+الكمية القليلة جدا من الـmyeloperoxidase enzyme
+
+350
+00:26:02,230 --> 00:26:07,210
+وشفوها الحاجة التانية اللي شخصوها by
+
+351
+00:26:07,210 --> 00:26:12,390
+immunophenotyping immunophenotyping يا جماعة الخير
+
+352
+00:26:12,390 --> 00:26:21,190
+هو عبارة عن من الإسم نظام تسمية للخلايا لتعرف على
+
+353
+00:26:21,190 --> 00:26:27,810
+الخلية من خلال الموليكيول اللي على سطحها سواء كانت
+
+354
+00:26:27,810 --> 00:26:30,550
+ريسبتور او انتيجين او whatever سميها زي ما بدك
+
+355
+00:26:30,550 --> 00:26:36,110
+المهم كل خلية فيها على سطحها موليكيول
+
+356
+00:26:36,110 --> 00:26:40,950
+مختلفة لهذه الموليكيول كيف تعرفوا عليها؟ راحوا
+
+357
+00:26:40,950 --> 00:26:50,290
+يعملوا antibody لكل موليكيول وفعلوا
+
+358
+00:26:50,290 --> 00:26:55,080
+هذا ال antibody معفي الخلايا اللى بتتفاعل الخلية
+
+359
+00:26:55,080 --> 00:26:58,120
+اللى بتتفاعل مع هذا ال antibody بيقول الله انها
+
+360
+00:26:58,120 --> 00:27:03,360
+positive for this molecule وبما ان ال molecules
+
+361
+00:27:03,360 --> 00:27:07,600
+كتيرة على سطح الخلايا وبالتالي ال monoclonal
+
+362
+00:27:07,600 --> 00:27:12,020
+antibody اللى كوّنوها كتيرة وعشان يسهلوا عملية
+
+363
+00:27:12,020 --> 00:27:18,140
+التسمية راحوا يدّوها أرقام ورمجوها
+
+364
+00:27:18,140 --> 00:27:23,450
+هذه الأرقامأرقام بـ CD سموها cluster of
+
+365
+00:27:23,450 --> 00:27:27,710
+differentiation CD رقم واحد، CD رقم اتنين، CD رقم
+
+366
+00:27:27,710 --> 00:27:33,950
+تلاتة يعني الـ CD هو عبارة عن الـ monoclonal
+
+367
+00:27:33,950 --> 00:27:38,230
+antibody اللي بيتفاعل مع certain molecule على
+
+368
+00:27:38,230 --> 00:27:43,170
+السطح الخلية certain يعني أحد هذه ال molecules
+
+369
+00:27:43,170 --> 00:27:47,350
+ماشي؟ وزي ما قلتلكوا رقموها و ادوها واحد و اتنين و
+
+370
+00:27:47,350 --> 00:27:52,660
+تلاتةلغاية اليوم فوق ال 400 different monoclonal
+
+371
+00:27:52,660 --> 00:27:56,160
+antibodies that are being used فبالتالي فينا فوق
+
+372
+00:27:56,160 --> 00:28:03,800
+ال 400 different CD ممكن نحكي فيهم فى ما إيش هنا
+
+373
+00:28:03,800 --> 00:28:09,080
+immuno حطوا كلمة immuno لإنه بنستخدم monoclonal
+
+374
+00:28:09,080 --> 00:28:14,400
+antibody antibody يعني مناعة فينه typing فينه يعني
+
+375
+00:28:14,400 --> 00:28:23,540
+سطحtyping تسمية أو typing من
+
+376
+00:28:23,540 --> 00:28:30,860
+type يعني النوع typing يعني نفحص
+
+377
+00:28:30,860 --> 00:28:38,920
+النوع اللي موجود ماشي immunophenotyping طيب هذا
+
+378
+00:28:38,920 --> 00:28:42,920
+النوع الأولاني ال nutrition حصلت على مستوى مبكر
+
+379
+00:28:42,920 --> 00:28:47,370
+جدا من ال maturation وبالتاليلسة الـ Primary
+
+380
+00:28:47,370 --> 00:28:51,390
+Granules لم تتكون بعد أو لسة في طريقة فبدأوا
+
+381
+00:28:51,390 --> 00:28:57,210
+يبحثوا على الـ Myeloproxidase in trace amount اللي
+
+382
+00:28:57,210 --> 00:29:02,470
+موجود in trace amount في الخلية ودرسوا إيش موجود
+
+383
+00:29:02,470 --> 00:29:06,830
+على سطح الخلية من الإيش من الموليكيول وميزوا هذه
+
+384
+00:29:06,830 --> 00:29:13,900
+الخلايا بهذا النوع سموه M0 ثم M1الأم واحد هي عبارة
+
+385
+00:29:13,900 --> 00:29:17,660
+عن الخلايا الـ acute myelogenous leukemia اللي
+
+386
+00:29:17,660 --> 00:29:20,940
+without maturation كل الخلايا بتكون mono morphic
+
+387
+00:29:20,940 --> 00:29:25,080
+الشو بيسموها mono يعني أحدى morphic الشكل أحدية
+
+388
+00:29:25,080 --> 00:29:29,680
+الشكل بيكون فيه طبعا ال blast موجودة with one or
+
+389
+00:29:29,680 --> 00:29:34,580
+more distinct nuclei الأوروذ body occasionally
+
+390
+00:29:34,580 --> 00:29:40,310
+seen تقريباالـ Primary Grants تكونت لكن بالنسبة
+
+391
+00:29:40,310 --> 00:29:43,410
+للتلاتة في المية المييلة بالريكزيديز الوزياتيتي
+
+392
+00:29:43,410 --> 00:29:47,770
+بتكون at least a three percent لساتها برضه مرحلة
+
+393
+00:29:47,770 --> 00:29:54,130
+مبكرة مرحلة التانية او ال M2هي acute myelogenous
+
+394
+00:29:54,130 --> 00:29:57,270
+leukemia with maturation الـ with maturation يعني
+
+395
+00:29:57,270 --> 00:30:01,510
+بدنا نشوف اكتر من مرحلة من مراحل ال maturation
+
+396
+00:30:01,510 --> 00:30:06,890
+steps فنشوف خمسين او اكتر myeloplast و pro
+
+397
+00:30:06,890 --> 00:30:12,410
+myelocyte وبيكون في single or odd body seen لكن
+
+398
+00:30:12,410 --> 00:30:16,050
+بيكون في this plastic this يعني abnormal plastic
+
+399
+00:30:16,050 --> 00:30:22,110
+منتجة myeloid differentiation يعني خلايا myeloid
+
+400
+00:30:22,380 --> 00:30:34,240
+مشوهة ماشي may be present طيب M3 باختصرها ب APL و
+
+401
+00:30:34,240 --> 00:30:38,860
+هي اختصار ل acute promyelocytic leukemia و من
+
+402
+00:30:38,860 --> 00:30:41,960
+الاسم promyelocytes يعني المرحلة اللي بعد ال
+
+403
+00:30:41,960 --> 00:30:46,320
+myeloblast ماشي طبعا الخلية ال dominant في هذه
+
+404
+00:30:46,320 --> 00:30:49,940
+الحالة يعني ال maturation وجه عندها هي ال
+
+405
+00:30:49,940 --> 00:30:53,230
+promyelocytesوفي هذه المرحلة بيكون heavy
+
+406
+00:30:53,230 --> 00:30:57,930
+azorophobic granules يعني primary granules وهذه ال
+
+407
+00:30:57,930 --> 00:31:03,250
+granules بتتكون في الخلية على شكل bundle يعني حزم
+
+408
+00:31:03,250 --> 00:31:08,810
+من ال our root body وجودها confirm the diagnosis
+
+409
+00:31:08,810 --> 00:31:17,490
+بيؤكد التشخيص وفي منها نوعين نوع كبير ماشي لإن
+
+410
+00:31:17,490 --> 00:31:20,430
+الخلية ال bromiocyte احنا بنعرف أنها أكبر من
+
+411
+00:31:20,430 --> 00:31:21,170
+myeloblast
+
+412
+00:31:23,510 --> 00:31:27,950
+والنوع التاني الصغير اللي بيسموه micro granular
+
+413
+00:31:27,950 --> 00:31:34,770
+variant بيسموه M3V النوع الرابع هو acute
+
+414
+00:31:34,770 --> 00:31:41,830
+myelomonoplastic leukemia وهذا النوع زي M2 يعني في
+
+415
+00:31:41,830 --> 00:31:46,750
+differentiation ولكن بنشوف monocyte لأنه
+
+416
+00:31:46,750 --> 00:31:51,180
+monoplasticفبنشوف اكتر من 20% من مونو بلاست
+
+417
+00:31:51,180 --> 00:31:57,860
+وبرومونو سايتس ومونو سايتس خمسة M5 هو acute
+
+418
+00:31:57,860 --> 00:32:05,140
+monoplastic leukemia وقسموها إلى نوعين M5A وM5B ال
+
+419
+00:32:05,140 --> 00:32:10,560
+M5A بيكون فيه اكتر من 80% من مونو بلاست فقط poorly
+
+420
+00:32:10,560 --> 00:32:18,540
+differentiated بيسموها بينما ال M5B بيكون فيها80%
+
+421
+00:32:18,540 --> 00:32:21,720
+فما فوق مونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+422
+00:32:21,720 --> 00:32:22,760
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+423
+00:32:22,760 --> 00:32:26,040
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+424
+00:32:26,040 --> 00:32:26,140
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+425
+00:32:26,140 --> 00:32:26,140
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+426
+00:32:26,140 --> 00:32:26,140
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+427
+00:32:26,140 --> 00:32:26,140
+بلاست ومونو بلاست ومونو بلاست ومونو بلاست ومونو
+
+428
+00:32:26,140 --> 00:32:36,960
+بلاست ومونو بلاست ومونو بلاست ومونو
+
+429
+00:32:36,960 --> 00:32:43,080
+بلاست
+
+430
+00:32:43,080 --> 00:32:49,260
+ومبزار يعني مش غير منتظم this plastic غير مشوه
+
+431
+00:32:49,260 --> 00:32:54,800
+يعني nucleated RBCs with multi nucleated form
+
+432
+00:32:54,800 --> 00:32:58,860
+بيكون فيه اكتر من nucleus في الخلية RBCs و فيها
+
+433
+00:32:58,860 --> 00:33:03,760
+اكتر من ايش من ال nucleusان سايتو بلازميك برجينج
+
+434
+00:33:03,760 --> 00:33:07,120
+ان سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+435
+00:33:07,120 --> 00:33:10,160
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+436
+00:33:10,160 --> 00:33:12,060
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+437
+00:33:12,060 --> 00:33:14,640
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+438
+00:33:14,640 --> 00:33:16,420
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+439
+00:33:16,420 --> 00:33:19,480
+سايتو بلازميك برجينج ان سايتو بلازميك برجينج ان
+
+440
+00:33:19,480 --> 00:33:27,520
+سايتو بلازميك برجينج ان سايتو بلازميك برجينم7
+
+441
+00:33:27,520 --> 00:33:31,720
+اكيوت ميجا كاريو بلاستيك لوكيميا وطبعا هنا في
+
+442
+00:33:31,720 --> 00:33:35,960
+فيبروسيس الخلية كبيرة و بتموت في ال بولمارو فبتعمل
+
+443
+00:33:35,960 --> 00:33:39,440
+فيبروسيس للبولمارووهي عبارة عن heterogeneous plus
+
+444
+00:33:39,440 --> 00:33:44,020
+population تتميز بوجود cytoplasmic plebs plebs
+
+445
+00:33:44,020 --> 00:33:48,000
+يعني براعم من ال cytoplasm و ال platelet
+
+446
+00:33:48,000 --> 00:33:51,860
+peroxidase activity is positive هذا عبارة عن
+
+447
+00:33:51,860 --> 00:33:56,840
+enzyme هذه عبارة عن السبع أنواع المختلفة اللي ممكن
+
+448
+00:33:56,840 --> 00:34:01,320
+نتعرف عليها في ال non lymphoplastic leukemia او ال
+
+449
+00:34:01,320 --> 00:34:08,040
+acute myelogenous او myeloid leukemiaطبعا من هنا
+
+450
+00:34:08,040 --> 00:34:11,800
+نطالع هو عبارة عن نفس الحكاية اللى توشرحتها بس
+
+451
+00:34:11,800 --> 00:34:16,820
+بنوع من ايش من التفصيل
+
+452
+00:34:16,820 --> 00:34:23,680
+او الفصل بين الأنواع كاتلين في plastic leukemia زى
+
+453
+00:34:23,680 --> 00:34:31,760
+ما اتفقنا قصة يعني عرفوها بإنه هذه this is the
+
+454
+00:34:31,760 --> 00:34:37,430
+most common وين موجودة في الأطفالوالبروجنوز تبعها
+
+455
+00:34:37,430 --> 00:34:41,230
+is best ايش يعني بروجنوز يعني الى ما يقول الي
+
+456
+00:34:41,230 --> 00:34:46,970
+المرض مستقبل المرض is best يعني كويس يعني ممكن
+
+457
+00:34:46,970 --> 00:34:50,850
+يشفى المريض اه ممكن يشفى بكون ال cell size is
+
+458
+00:34:50,850 --> 00:34:54,470
+small fine or clumped homogeneous nuclear
+
+459
+00:34:54,470 --> 00:35:00,030
+chromatin وفي غياب لل او غير مرئية لل nucleoli
+
+460
+00:35:01,190 --> 00:35:07,950
+والشكل النووي هو عادى مرات يكون النوكليا محطمة أو
+
+461
+00:35:07,950 --> 00:35:13,090
+مفهومة سايتو بلازم تسكنت مع اتفاقات تسيطرة
+
+462
+00:35:13,090 --> 00:35:21,850
+بيزوفيليا وفاكولات مختلفةالنوع التاني طبعا most
+
+463
+00:35:21,850 --> 00:35:25,950
+frequent أكيد لينفو بلاستيك لقيمة موجودة في ال
+
+464
+00:35:25,950 --> 00:35:32,310
+adult ال cell size is large و هتروجناس متباينة
+
+465
+00:35:32,310 --> 00:35:35,750
+بيكون فيه variable chromatin a prominent nucleoli
+
+466
+00:35:35,750 --> 00:35:41,670
+نوكلياس is irregular clifting and intended
+
+467
+00:35:41,670 --> 00:35:43,550
+commonly seen
+
+468
+00:35:48,340 --> 00:35:54,320
+بكون abundant يعني زيادة عن الطبيعي في بيزوفيليا
+
+469
+00:35:54,320 --> 00:35:59,700
+لكنها variable و مرات بتكون deep and vacuums are
+
+470
+00:35:59,700 --> 00:36:06,100
+variable وهي الواحد و زي سايم انتوا شايفين الخلية
+
+471
+00:36:06,100 --> 00:36:10,400
+مشققة من عند ال nucleus هداي ال nucleus ماخدة كل
+
+472
+00:36:10,400 --> 00:36:17,330
+حجم الخلية في cytoplasm very scantyقليل هى وهنا
+
+473
+00:36:17,330 --> 00:36:23,110
+قليل جدا وهى مشقوقة القليل homogeneous population
+
+474
+00:36:23,110 --> 00:36:31,110
+of chromatic material nucleus nuclei is indistinct
+
+475
+00:36:31,110 --> 00:36:37,690
+ده هى زى ما انتوا شايفين ماشى و هكذا طبعا purple
+
+476
+00:36:37,690 --> 00:36:43,230
+deep purple and color وهنا فى ال bone marrow اى
+
+477
+00:36:43,230 --> 00:36:46,880
+خلايابارا عن childhood acute lymphoblastic
+
+478
+00:36:46,880 --> 00:36:55,200
+leukemia ماشي it has high nucleocytoplasmic ratio
+
+479
+00:36:55,200 --> 00:36:59,140
+ايش يعني high nucleus to cytoplasmic ratio نسبة ال
+
+480
+00:36:59,140 --> 00:37:02,520
+nucleus مع ال nucleus محدد كله للخليل فالcytoplasm
+
+481
+00:37:02,520 --> 00:37:06,740
+نسبته قليلة و ال nucleus نسبتها كبيرة فال ratio
+
+482
+00:37:06,740 --> 00:37:09,660
+بتكون عالية ال ratio يعيش بتكون عالي
+
+483
+00:37:13,710 --> 00:37:18,290
+طبعا هنا زى ما انتوا شايفين امينوفينو تايبن كمان
+
+484
+00:37:18,290 --> 00:37:23,270
+بتاخد اذا بيشتغل كيميك سيل وير بي لينيش بي يعني من
+
+485
+00:37:23,270 --> 00:37:31,430
+نوع ال بي وعلى سطحه CD10 CD10 ماشي هذا امينوفينو
+
+486
+00:37:31,430 --> 00:37:36,190
+تايبن هى الاتنين هى الست سايتوم لازم كتر شوية
+
+487
+00:37:38,060 --> 00:37:41,820
+النوكليوس لازالت ماخدة حجم كبير من الخلية لكن فيه
+
+488
+00:37:41,820 --> 00:37:46,600
+تباين في الحجم هي هذه خلية صغيرة هذه اكبر اكبر
+
+489
+00:37:46,600 --> 00:37:54,600
+ماشي نوكليولا is not seen indistinct و مافيش اورد
+
+490
+00:37:54,600 --> 00:38:02,140
+body و still nucleus is verbal و هي ال nucleus
+
+491
+00:38:02,140 --> 00:38:04,920
+اللي قلته في البرمر
+
+492
+00:38:09,640 --> 00:38:13,980
+وقبل تلاتة اتفقنا على ان هي عبارة عن the largest
+
+493
+00:38:13,980 --> 00:38:20,200
+the rarest و largest type of acute lymphoblastic
+
+494
+00:38:20,200 --> 00:38:24,080
+leukemia، sizes large، فيه fine chromatin،
+
+495
+00:38:24,080 --> 00:38:26,900
+homogeneous nuclear chromatin material، فيه
+
+496
+00:38:26,900 --> 00:38:33,220
+prominent nuclei، nucleus is irregular over or
+
+497
+00:38:33,220 --> 00:38:39,480
+around، والcytoplasm is moderately abundant،و
+
+498
+00:38:39,480 --> 00:38:43,520
+بيكون deeply basophilic and vaculated و هي هذا هو
+
+499
+00:38:43,520 --> 00:38:46,280
+زي ما انتوا شايفين ال vacuoles بس مش واضحانة صغيرة
+
+500
+00:38:46,280 --> 00:38:49,720
+ماشي فى vacuoles فى ال cytoplasm فى نيوكليو
+
+501
+00:38:49,720 --> 00:38:56,400
+لعيداية prominent ماشي و هكذا شايفين لأول مرة و
+
+502
+00:38:56,400 --> 00:39:00,460
+كيف واضح ال vaculation فى ال cytoplasm تماما واضح
+
+503
+00:39:04,710 --> 00:39:07,490
+على الـ Incidence بتاعة الـ Acute Lymphoblastic
+
+504
+00:39:07,490 --> 00:39:12,010
+Leukemia جالو يصيب الأطفال من سنين لخمسة لكن برضه
+
+505
+00:39:12,010 --> 00:39:15,990
+ممكن نشوفها في الـ Adult الـ Clinical Finding في
+
+506
+00:39:15,990 --> 00:39:21,010
+Pancytopemia وفي Fatigue وPellor وFever و Weight
+
+507
+00:39:21,010 --> 00:39:25,290
+Loss و Irritability, Anorexia, Infection, Bleeding
+
+508
+00:39:25,290 --> 00:39:29,150
+and Bone Marrow ال Pancytopemia يعني إيش
+
+509
+00:39:29,150 --> 00:39:34,250
+Pancytopemia؟ Pan يعني كل أنواع الخلايا is reduced
+
+510
+00:39:34,770 --> 00:39:41,710
+ساعته خلية وبينيا قلة طبعا بالاضافة إلى ذلك فيه ال
+
+511
+00:39:41,710 --> 00:39:45,650
+signs of anemia fatigue و pallor وفيه signs of
+
+512
+00:39:45,650 --> 00:39:52,910
+infection fever وفيه weight loss لأن ال metabolic
+
+513
+00:39:52,910 --> 00:39:56,550
+rate بتكون عالية جدا وواحد من هالنوع بيكون
+
+514
+00:39:56,550 --> 00:40:02,840
+irritableوهو بيفقد شعيته انوركسيا وفي عنده
+
+515
+00:40:02,840 --> 00:40:08,360
+infection و bleeding وممكن bone pain قال واحد
+
+516
+00:40:08,360 --> 00:40:11,420
+بنشوفه في الأطفال قال اتنين بنشوفه في ال adults
+
+517
+00:40:11,420 --> 00:40:18,880
+قال تلاتة بيسموها Perkits leukemia بيقول موزيز
+
+518
+00:40:18,880 --> 00:40:26,020
+يعني ال ageمهم و ال white blood cell count مهم و
+
+519
+00:40:26,020 --> 00:40:30,580
+cell type هم او يعني they are the most important
+
+520
+00:40:30,580 --> 00:40:34,120
+prognostic indicator هم ال prognostic أيش
+
+521
+00:40:34,120 --> 00:40:39,900
+indicator فجعل المريض البرضة اللي عمرهم اقل من سنة
+
+522
+00:40:39,900 --> 00:40:47,200
+و اكتر من تلتاشر سنة عندهم poor prognosis لكن اذا
+
+523
+00:40:47,200 --> 00:40:50,840
+ال white blood cell count اقل من عشر تلاف عند
+
+524
+00:40:50,840 --> 00:40:51,460
+التشخيص
+
+525
+00:40:59,450 --> 00:41:05,210
+التاسل نوع التالت من الخلايا السبب التالت او
+
+526
+00:41:05,210 --> 00:41:10,630
+الكريتيريا التالتة التاسل اكيوتلينفابلاستيكلوكينة
+
+527
+00:41:10,630 --> 00:41:17,070
+نشوفها كتير في ال male ويلها poor prognosis بينما
+
+528
+00:41:17,070 --> 00:41:23,950
+ال dieselهذا الـ Q-rate يشفي منها المريض وتوصل
+
+529
+00:41:23,950 --> 00:41:31,290
+نسبة الشفاء إلى 70% طبعا
+
+530
+00:41:31,290 --> 00:41:34,090
+هذا ما يتعلق بالـ acute lymphoblastic leukemia الا
+
+531
+00:41:34,090 --> 00:41:37,430
+الـ acute myeloid leukemia برضه نشوفها بيسموها
+
+532
+00:41:37,430 --> 00:41:41,690
+acute granulocytic leukemia و ال classification
+
+533
+00:41:41,690 --> 00:41:48,770
+بيعتمد على البودماروبلاست morphology و
+
+534
+00:41:53,380 --> 00:41:58,800
+نقف هنا نقف
+
+535
+00:41:58,800 --> 00:42:03,900
+هنا ناخد استراحة و نكمل ان شاء الله لحظة
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/jBd3ATbh9Gk_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/jBd3ATbh9Gk_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ae32801c2b6e66f1fa94cba22ec6abffdd9650b8
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/jBd3ATbh9Gk_raw.srt
@@ -0,0 +1,1324 @@
+1
+00:00:04,550 --> 00:00:11,090
+طيب استكمالا للمحاضرة السابقة وصلنا الى الماء ال
+
+2
+00:00:11,090 --> 00:00:14,950
+absorption قولنا فيه تلت أسباب السبب الأولاني lack
+
+3
+00:00:14,950 --> 00:00:18,450
+of intrinsic factor وشوفنا ال pernicious anemia
+
+4
+00:00:18,450 --> 00:00:22,210
+كمثال عليه السبب التاني gastrointestinal disease
+
+5
+00:00:22,210 --> 00:00:28,170
+أي خلل أو مرض في الجهاز العضمي و الأمثلة على دالك
+
+6
+00:00:28,170 --> 00:00:32,870
+كثيرة منها على سبيل المثالانه يصير فيه total
+
+7
+00:00:32,870 --> 00:00:38,250
+gastric to me يعني نجس المعدة كاملا و طبعا هذه
+
+8
+00:00:38,250 --> 00:00:45,630
+بيعني انه نشيل ال source of intrinsic factor يوم
+
+9
+00:00:45,630 --> 00:00:49,250
+ما ينشال يعني وجفنا ال absorption كماما وبالتالي
+
+10
+00:00:49,250 --> 00:00:53,550
+أنميا هتظهر megaloplastic أنميا هتظهر خلال خمس
+
+11
+00:00:53,550 --> 00:00:59,330
+سنوات لانه جلنا مخزون لمن تلاتة لسبع سنوات جلنا
+
+12
+00:01:00,140 --> 00:01:05,980
+السبب التانى هو انك تشيل جزء من ال stomach و طبعا
+
+13
+00:01:05,980 --> 00:01:09,680
+بعد ما تشيل جزء من ال stomach بتروح انت رابط الجزء
+
+14
+00:01:09,680 --> 00:01:14,820
+المتبقي بالاثنى عشر و بيسمو هذه العملية stagnant
+
+15
+00:01:14,820 --> 00:01:22,790
+أو blind loop syndromeماذا يحدث في هذه الحالة ال
+
+16
+00:01:22,790 --> 00:01:32,970
+micro flora اللى موجودة في الأمعاق هتسكن او تستوطن
+
+17
+00:01:32,970 --> 00:01:40,490
+ال 12 و برضه في هذه الحالة هتبدأ تستهلك البكتيريا
+
+18
+00:01:40,490 --> 00:01:45,170
+كمية كبيرة من ايش من ال vitamin و هنفقد ال vitamin
+
+19
+00:01:46,330 --> 00:01:50,510
+السبب التالت اليالتريسيكشن انك تشيل او تعمل بسمها
+
+20
+00:01:50,510 --> 00:01:55,070
+اليستامين بانك تشيل الجزء الخاص بامتصاص vitamin
+
+21
+00:01:55,070 --> 00:02:03,250
+B12 الريسبتور و برضه هذا هيقدي الى ايش الى عدم
+
+22
+00:02:03,250 --> 00:02:09,600
+امتصاص ال vitaminالسبب الرابع هو ال cross disease
+
+23
+00:02:09,600 --> 00:02:14,840
+هو عبارة عن granulomatous disease اشواء مرض حبيبي
+
+24
+00:02:14,840 --> 00:02:22,660
+حبيبات بتغطي كل الأمعاق و بالذات ال terminal
+
+25
+00:02:22,660 --> 00:02:26,820
+helium اللى فيها ال receptor و ال ascending colon
+
+26
+00:02:26,820 --> 00:02:32,940
+و طبعا هذا بيأدى إلى خلل في امتصاص كل ال nutrient
+
+27
+00:02:32,940 --> 00:02:38,510
+و من ضمنها ال vitamin B12سبب خامس هو ال
+
+28
+00:02:38,510 --> 00:02:42,550
+infestation of the gut with a fish tab worm انه
+
+29
+00:02:42,550 --> 00:02:46,690
+الله يكون المريض عنده او الانسان عنده تاب ورم
+
+30
+00:02:46,690 --> 00:02:51,130
+موجودة في ال intestine و اشهر تنتين بيستهلكوا ال
+
+31
+00:02:51,130 --> 00:02:58,470
+vitamin B12 هم ال diphylopetrium الاتم و النكوتر
+
+32
+00:02:58,470 --> 00:02:59,550
+امريكانا
+
+33
+00:03:02,030 --> 00:03:06,390
+سبب التالت في المال absorption هو drug induced
+
+34
+00:03:06,390 --> 00:03:11,470
+وقلنا انه يدخل ال drug يعمل inhibition او
+
+35
+00:03:11,470 --> 00:03:16,190
+impairment لل B12 absorption هم اكثر ال drugs اللي
+
+36
+00:03:16,190 --> 00:03:21,930
+ممكن تعمل هيك اسناء منها ال anticonvulsant ومثال
+
+37
+00:03:21,930 --> 00:03:28,410
+عليها ال phenytoin او antimicrobial زي ال neomycin
+
+38
+00:03:29,280 --> 00:03:36,320
+أو Anti-Gout زي الـ Colchicine او
+
+39
+00:03:36,320 --> 00:03:46,680
+Alcohol تعاطي الالكول سبب التالت في ال vitamin B
+
+40
+00:03:46,680 --> 00:03:48,860
+والـ deficiency increase requirement والـ
+
+41
+00:03:48,860 --> 00:03:54,140
+requirement perceived during pregnancy الفتاة في
+
+42
+00:03:54,140 --> 00:03:58,260
+هذه الحالة إذا كانت على borderline مخزنها
+
+43
+00:03:59,660 --> 00:04:05,900
+بتتأثر اللي هو during pregnancy اخر سبب في vitamin
+
+44
+00:04:05,900 --> 00:04:10,460
+B12 هو اللي هو failure to transport the vitamin
+
+45
+00:04:10,460 --> 00:04:16,000
+ويجدوا ان كان rare انه فيه congenital deficiency
+
+46
+00:04:16,000 --> 00:04:19,240
+في الناقل اللي هو ال physiological active
+
+47
+00:04:19,240 --> 00:04:24,380
+transport Transporter اللي هو Transcobalamine 2
+
+48
+00:04:24,380 --> 00:04:33,400
+هذا بيؤدي الى vitamin B12 deficiencyطبعا ممكن احنا
+
+49
+00:04:33,400 --> 00:04:37,960
+اهد الحالة يصير مصحوبة بال neurological damage لكن
+
+50
+00:04:37,960 --> 00:04:46,740
+اكتشافها مبكرا بيمنع وجود ال neurological damage
+
+51
+00:04:46,740 --> 00:04:52,180
+سبب اخير failure to metabolize the vitamin B12
+
+52
+00:04:52,180 --> 00:04:56,340
+والله اخدنا ال vitamin لكن مافي كوينزايم اللي هو
+
+53
+00:04:56,340 --> 00:05:04,250
+يساعد اختيمافي استهلاك لل vitamin وبالتالي مابنحول
+
+54
+00:05:04,250 --> 00:05:11,330
+ال vitamin to its active coenzyme طبعا في هذا
+
+55
+00:05:11,330 --> 00:05:16,770
+الحالة بيؤدي إلى زيادة في ال methylmalonic acid و
+
+56
+00:05:16,770 --> 00:05:21,170
+ال homocysteine في ال urine لإنه ماصار فيه لهماش
+
+57
+00:05:21,170 --> 00:05:24,790
+امتصاص
+
+58
+00:05:26,230 --> 00:05:29,990
+غالبا المرضى هذول بيصيروا mentally retarded و
+
+59
+00:05:29,990 --> 00:05:33,810
+بيكونوا megaloplastic
+
+60
+00:05:33,810 --> 00:05:39,390
+بيكونوش megaloplastic anemia لسبب غير معروف لكن هم
+
+61
+00:05:39,390 --> 00:05:47,030
+بيصيروا mentally retarded من ايضا ال failure to
+
+62
+00:05:47,030 --> 00:05:50,830
+metabolize the vitamin وجدوا ان ال anaesthetic
+
+63
+00:05:50,830 --> 00:05:54,610
+nitrous oxide بيعمل inactivation لل vitamin B12
+
+64
+00:05:54,610 --> 00:05:58,710
+كوانزايموبالتالي ممكن يعمل ميجالو بلاستيك تشينجيز
+
+65
+00:05:58,710 --> 00:06:05,370
+و نيورو باتي نيورو باتي يعني خلل في العصاب هذا ما
+
+66
+00:06:05,370 --> 00:06:10,010
+يخص ال vitamin B12 deficiency الفرق أسد deficiency
+
+67
+00:06:10,010 --> 00:06:16,750
+أسبابه أيضا نفس أسباب اللي هو ال vitamin B12 خليني
+
+68
+00:06:16,750 --> 00:06:21,380
+نتطرق إليهاعلى السريع لان adequate dietary intake
+
+69
+00:06:21,380 --> 00:06:27,420
+كانت غير عامة لثلاث أسباب برضه ان كمية الأكل في
+
+70
+00:06:27,420 --> 00:06:32,240
+700 ميكرو جرام من الفولية لكن تقريبا اكتر من النص
+
+71
+00:06:32,240 --> 00:06:38,920
+بروح أثناء الطبخنمرة اتنين الفوليك اسد هو الاباق
+
+72
+00:06:38,920 --> 00:06:42,520
+اللى تحرر وبالتالي اكتر من تسعين فمية ايضا منه
+
+73
+00:06:42,520 --> 00:06:48,020
+بروح اثناء الطبخ السبب التالت مخازننا للفوليك اسد
+
+74
+00:06:48,020 --> 00:06:53,220
+فيها تلاتة الى اربعة في عشرة ملي جرام لكنها لا
+
+75
+00:06:53,220 --> 00:06:59,040
+تكفينا الا الى تلات شهورسبب التاني اللى هو
+
+76
+00:06:59,040 --> 00:07:03,940
+malabsorption ووجدوا حالات كثيرة مرضه بيصير فيها
+
+77
+00:07:03,940 --> 00:07:09,900
+malabsorption زى ال celiac disease وهذا بيصير فيه
+
+78
+00:07:09,900 --> 00:07:15,480
+atrophy لل villi اللى بتبطن جدار الأمعاء وتساعد
+
+79
+00:07:15,480 --> 00:07:19,310
+على حركة الدودية وبالتالي مافيش شيءفولك أسد في
+
+80
+00:07:19,310 --> 00:07:24,850
+الabsorption لأنه يمتص الفولك أسد من ال epic place
+
+81
+00:07:24,850 --> 00:07:30,610
+of villi من طرف الفجاني تبع ال villi tropical
+
+82
+00:07:30,610 --> 00:07:36,610
+sprue tropical استواعي يعني sprue وهو عبارة عن مرض
+
+83
+00:07:36,610 --> 00:07:44,230
+بيصير فيه إسهال شديد وبالتالي مافيش فرصة للانتصاص
+
+84
+00:07:45,390 --> 00:07:49,430
+cross disease حكيناها قبل هيك برضه جينراليزي مع
+
+85
+00:07:49,430 --> 00:07:52,730
+الabsorption بيصير في الانتستان increase
+
+86
+00:07:52,730 --> 00:07:57,010
+requirement بتزيد الحاجة ل ال folic acid غالبا في
+
+87
+00:07:57,010 --> 00:08:00,450
+ال pregnancy وفي ال pregnancy وجدوا انه دي
+
+88
+00:08:00,450 --> 00:08:04,990
+requirement for folate بتوصل خمسمية microgram مش
+
+89
+00:08:04,990 --> 00:08:10,700
+مية خمسمية و بالذات في ال third trimesterأكتر من
+
+90
+00:08:10,700 --> 00:08:14,360
+ستين في المية من الستات بيخشوا او بيصير معاهم
+
+91
+00:08:14,360 --> 00:08:21,580
+pregnancy و المخزون عندهم subnormal مخازن بيكون
+
+92
+00:08:21,580 --> 00:08:27,320
+فيها subnormal folate concentration و طبعا هذا
+
+93
+00:08:27,320 --> 00:08:32,240
+الكلام اللي هالي ايام بتشوفه associated ال
+
+94
+00:08:32,240 --> 00:08:35,260
+pregnancy يعني associated with neural tube defect
+
+95
+00:08:35,260 --> 00:08:45,760
+يعني بيصير فيه خللخلقي في الجنين عشان ذلك بنعطى
+
+96
+00:08:45,760 --> 00:08:50,180
+Prophylactic Folic Acid Therapy is recommended
+
+97
+00:08:50,180 --> 00:08:53,260
+several months before conception قبل تلت اربع شهور
+
+98
+00:08:53,260 --> 00:08:59,040
+من نياج من الحمل ايضا ال increase requirement
+
+99
+00:08:59,040 --> 00:09:03,240
+بتشير في حالات الانيميا و خصوصا الناس اللي عندهم
+
+100
+00:09:03,240 --> 00:09:06,880
+Hemocronic Hemolytic Condition زي ال sickle cell
+
+101
+00:09:06,880 --> 00:09:07,420
+انيميا
+
+102
+00:09:10,130 --> 00:09:14,770
+التي تزيد تنبالة
+
+103
+00:09:14,770 --> 00:09:17,910
+اذا كان فيها فوليد اكسيد تنبالة اذا كان فيها فوليد
+
+104
+00:09:17,910 --> 00:09:20,910
+اكسيد تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة
+
+105
+00:09:20,910 --> 00:09:21,990
+تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة
+
+106
+00:09:21,990 --> 00:09:21,990
+تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة
+
+107
+00:09:21,990 --> 00:09:22,750
+تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة
+
+108
+00:09:22,750 --> 00:09:23,870
+تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة تنبالة
+
+109
+00:09:23,870 --> 00:09:28,830
+تنبالة تنبالة
+
+110
+00:09:28,830 --> 00:09:35,790
+تنبالة
+
+111
+00:09:36,080 --> 00:09:41,700
+بلزمها عشر أضعاف كمية الفوليك أسد عشان تصنع DNA
+
+112
+00:09:41,700 --> 00:09:45,180
+للخلايا وبالتالي هذا الكلب لا جوهش في الأكل
+
+113
+00:09:45,180 --> 00:09:51,200
+فبالتالي بيصير فيه increase requirement سابقا خير
+
+114
+00:09:51,200 --> 00:09:55,200
+drug-induced folate deficiency وجدوا كثير من
+
+115
+00:09:55,200 --> 00:10:00,200
+العلاجات زي long term therapy with anticonvulsant
+
+116
+00:10:00,200 --> 00:10:06,310
+الفينيطايل alcoholوالـ methotrexate اللي هو عبارة
+
+117
+00:10:06,310 --> 00:10:10,450
+عن drug cytotoxic بيعمل انهيابشين لـ dihydrofolate
+
+118
+00:10:10,450 --> 00:10:15,750
+reductase enzyme وبالتالي caused depletion of
+
+119
+00:10:15,750 --> 00:10:21,870
+thymidine and purine nucleotide أخر الأسباب
+
+120
+00:10:21,870 --> 00:10:29,430
+failure و folate metabolism قمنا عملية فشل
+
+121
+00:10:29,430 --> 00:10:33,060
+ال folate metabolism ناجي عنA rare enzyme
+
+122
+00:10:33,060 --> 00:10:36,780
+deficiency يقول ان هناك عدد من الانزيمات تدخل في
+
+123
+00:10:36,780 --> 00:10:40,360
+عملية metabolism فالفوليك أسد وإذا كان غيبت معناته
+
+124
+00:10:40,360 --> 00:10:47,300
+غيبت عملية متابوليك فالفوليك أسد وينتج غالبا في
+
+125
+00:10:47,300 --> 00:10:52,860
+مجاله plastic changes and mental retardation ماشي
+
+126
+00:10:52,860 --> 00:10:58,520
+هي بهيك بنكون حاكين عن both vitamin B12 وفوليك أسد
+
+127
+00:10:59,120 --> 00:11:03,620
+في علاقتهم بالميجالو بلاستيك أنيميا الآن خلّيني
+
+128
+00:11:03,620 --> 00:11:08,060
+ندخل على pathophysiology of megaloplastic anemia
+
+129
+00:11:08,060 --> 00:11:13,660
+المريض اللي عنده ميجالو بلاستيك أنيميا غالبا بيكون
+
+130
+00:11:13,660 --> 00:11:17,960
+عنده كل مظاهر الأنيميا العامة weakness shortness
+
+131
+00:11:17,960 --> 00:11:21,000
+of breath congestive heart failure وفي بعض الحالات
+
+132
+00:11:21,000 --> 00:11:23,820
+بيحصل في loss of appetite weight loss and
+
+133
+00:11:23,820 --> 00:11:29,290
+gastrointestinal disturbancesلكن بالاضافة الى
+
+134
+00:11:29,290 --> 00:11:35,550
+المظاهر الانيمية العامة في مظاهر خاصة بال
+
+135
+00:11:35,550 --> 00:11:45,110
+megaloplastic anemia زى ما يؤثر على ال affecting
+
+136
+00:11:45,110 --> 00:11:49,090
+tissue لإن احنا بلزمنا بناء خلايا فبالتالي كل
+
+137
+00:11:49,090 --> 00:11:53,790
+الخلايا which are rapidly dividing cellall will be
+
+138
+00:11:53,790 --> 00:11:57,330
+affected لأنه بيصير فيها impairment للميوتوتك ام
+
+139
+00:11:57,330 --> 00:12:01,690
+فانكشن و بيصير فيه premature cell death في هذه
+
+140
+00:12:01,690 --> 00:12:07,490
+الحالة لأنه مافي عوامل بناء و طبعا هذا الكلام ممكن
+
+141
+00:12:07,490 --> 00:12:11,130
+نشوفه في المظاهر الآتية نمرة واحدة general tissue
+
+142
+00:12:11,130 --> 00:12:16,150
+manifestation غياب
+
+143
+00:12:16,150 --> 00:12:21,230
+البوطنفاة من بيطول بولفليكاسدaffect all dividing
+
+144
+00:12:21,230 --> 00:12:28,590
+زى ما قلنا rapidly dividing cell و these
+
+145
+00:12:28,590 --> 00:12:33,790
+disturbances بتؤثر بشكل خاص على ال epithelial cell
+
+146
+00:12:33,790 --> 00:12:41,030
+فبصير في عند المريض angular stomatitis يعني التهاب
+
+147
+00:12:41,030 --> 00:12:46,610
+في طرفي الفم أو glossitis هي inflammation of the
+
+148
+00:12:46,610 --> 00:12:51,590
+tongueوغالبا بيحصل فيه neurological manifestation
+
+149
+00:12:51,590 --> 00:12:57,070
+من خلال انه بيحصل فيه degeneration هريان في
+
+150
+00:12:57,070 --> 00:13:01,450
+الدورزل and lateral column of the spinal cord كل
+
+151
+00:13:01,450 --> 00:13:08,250
+اللي هيش ال nerve سواء كانت دورزل او lateral
+
+152
+00:13:08,250 --> 00:13:12,690
+جانبية او خلفية اللي موجودة في ال spinal cord will
+
+153
+00:13:12,690 --> 00:13:14,310
+be degenerated
+
+154
+00:13:16,500 --> 00:13:18,580
+هذا الكلام يحدث في مصادر مصادر مصادر مصادر مصادر
+
+155
+00:13:18,580 --> 00:13:19,440
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+156
+00:13:19,440 --> 00:13:19,860
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+157
+00:13:19,860 --> 00:13:22,720
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+158
+00:13:22,720 --> 00:13:25,720
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+159
+00:13:25,720 --> 00:13:25,800
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+160
+00:13:25,800 --> 00:13:28,760
+مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر
+
+161
+00:13:28,760 --> 00:13:38,950
+مصادهي عبارة عن ظاهرة بيصير فيها اللي هو يعني
+
+162
+00:13:38,950 --> 00:13:44,390
+تخليق عيب خلقي في الجنين زي الـ Spina Bifida اللي
+
+163
+00:13:44,390 --> 00:13:52,510
+هو الفتحة اللي بتصير في ذهر و هذه من أشهر الحالات
+
+164
+00:13:52,510 --> 00:13:59,010
+في العيب الخلقي للجنين كمان بيصير في اللي هو
+
+165
+00:13:59,010 --> 00:14:06,310
+Dimensiaو ال dimension هي عبارة عن نوع من الخرف
+
+166
+00:14:06,310 --> 00:14:13,310
+and impairment of intellectual function بيصير فيه
+
+167
+00:14:13,310 --> 00:14:22,730
+ايش؟ بيصير فيه فشل او خلل في قدرته على التواصل طيب
+
+168
+00:14:22,730 --> 00:14:27,030
+هذا بالنسبة لل general tissue طيب what about bone
+
+169
+00:14:27,030 --> 00:14:30,670
+marrow؟ يعني ال hematological manifestationفي
+
+170
+00:14:30,670 --> 00:14:32,770
+الميجانو بلاستيك أنينيا البولمارو بيصير
+
+171
+00:14:32,770 --> 00:14:36,810
+hypercellular فيه زيادة طلب على الخلايا فبصير
+
+172
+00:14:36,810 --> 00:14:41,790
+يتنشط كتير لكن للأسف الشديد بيكون فيه خلل في
+
+173
+00:14:41,790 --> 00:14:46,530
+التصنيع فبصير في القاتل بيصير في increase لل
+
+174
+00:14:46,530 --> 00:14:51,210
+erythropoietic activity لكن زي ما قلنالكوا ال
+
+175
+00:14:51,210 --> 00:14:57,030
+immature form of all cells بتضل immature و بتجعد
+
+176
+00:14:57,030 --> 00:15:01,230
+فترة وبعدين بتموت بدريولمّا تموت بدري بيصير في
+
+177
+00:15:01,230 --> 00:15:05,470
+حاجة سمناها ineffective hemopoiesis شرحتناها قبل
+
+178
+00:15:05,470 --> 00:15:10,890
+هيك وطبعا هذه محصلتها pancytopemia إيش يعني
+
+179
+00:15:10,890 --> 00:15:15,330
+pancytopemia؟ pan يعني كل، cyt يعني خلية، penia
+
+180
+00:15:15,330 --> 00:15:21,490
+قلة بيصير في قلة في كل أنواع الخلايا وهذا ما يميز
+
+181
+00:15:21,490 --> 00:15:28,190
+هذا النور الحاجات
+
+182
+00:15:28,190 --> 00:15:32,770
+التانية اللي بنشوفهاهنا بيصير فيه زيادة لإنه فيه
+
+183
+00:15:32,770 --> 00:15:38,530
+تكسير زايد في الخلايا الدم الحمراء او ال precursor
+
+184
+00:15:38,530 --> 00:15:44,330
+of RBCs فبيصير فيه unconjugated bilirubin بزيد
+
+185
+00:15:44,330 --> 00:15:48,830
+تركيزه كمان بيصير فيه زيادة في ال LDH لإنه فيه
+
+186
+00:15:48,830 --> 00:15:54,150
+تكسير للcell membrane و ال lysozyme وهذه بالتالي
+
+187
+00:15:54,150 --> 00:15:59,390
+من ال chemical manifestation متمثلة بهذه الأوامر
+
+188
+00:16:00,200 --> 00:16:03,260
+هذا بالنسبة لبنور و ال chemistry طب بالنسبة ل ال
+
+189
+00:16:03,260 --> 00:16:05,920
+peripheral blood جاله في ال peripheral blood طبعا
+
+190
+00:16:05,920 --> 00:16:10,040
+بتلاقي فيه macro cytosis macro عشان هيك هذه مثال
+
+191
+00:16:10,040 --> 00:16:13,920
+حي ل macrocytic anemia و بيكون فيه
+
+192
+00:16:13,920 --> 00:16:17,400
+reticulocytopenia طبيعي مافيش إنتاج وبالتالي ال
+
+193
+00:16:17,400 --> 00:16:20,840
+reticulocyte ما بتنزل على البنور على ال peripheral
+
+194
+00:16:20,840 --> 00:16:24,480
+blood وبالتالي بيصير فيه قلة في ال reticulocyte
+
+195
+00:16:24,480 --> 00:16:29,390
+أيضامن الحاجات اللي كمان بنشوفها انه بيصير في
+
+196
+00:16:29,390 --> 00:16:36,750
+ميجانو بلاستيك لليكوبيويسيز وانت بنشوفها متمثلة
+
+197
+00:16:36,750 --> 00:16:41,390
+شغلة في ال bone marrow وشغلة في ال peripheral
+
+198
+00:16:41,390 --> 00:16:45,070
+blood الظاهرة تبعت ال bone marrow انه بيصير في
+
+199
+00:16:45,070 --> 00:16:49,390
+giant metamylocyte وفي ال peripheral blood بنشوف
+
+200
+00:16:49,390 --> 00:16:54,130
+hyper-segmented neutrophilيبقى الـ megaloplastic
+
+201
+00:16:54,130 --> 00:16:58,750
+leukopoiesis يعني الليكوسايت بتتأثر بشغلتين اللي
+
+202
+00:16:58,750 --> 00:17:02,170
+في البومبرا هو بيصير فيه giant metamirocyte وفي
+
+203
+00:17:02,170 --> 00:17:05,150
+البرفرالبلاد بيصير فيه hypersegmented neutrophil
+
+204
+00:17:05,150 --> 00:17:11,590
+طيب ماضلش الا نحكي على ال mega karyocyte جاله برضه
+
+205
+00:17:11,590 --> 00:17:15,910
+بيصير فيه megaloplastic megakaryocyte وهذه طبعا
+
+206
+00:17:15,910 --> 00:17:21,170
+مشكلة لإنه أصلا megakaryocyte كبيرة خلية كبيرةفما
+
+207
+00:17:21,170 --> 00:17:24,170
+تبقى لكوا لما بتصير ميجال و ميجال و plastic يعني
+
+208
+00:17:24,170 --> 00:17:29,010
+بتكبر اكتر فبصير فيه زيادة في ال size و بصير فيه
+
+209
+00:17:29,010 --> 00:17:36,250
+فشل في ال granulation تبعت ال mega carrier size
+
+210
+00:17:36,250 --> 00:17:42,810
+يعني ما بتتكون ال platelet ولكن هذه المظاهر اللي
+
+211
+00:17:42,810 --> 00:17:47,430
+اتوراهم على ما يخص اللي هو الميجال و plastic
+
+212
+00:17:47,430 --> 00:17:51,470
+أنيمياخلّيني على السريع نمشي على ال summary ال
+
+213
+00:17:51,470 --> 00:17:56,490
+practical approach زي ما اتفقنا تمنع macrocytosis
+
+214
+00:17:56,490 --> 00:17:59,830
+بشكل عام بندور إذا كان المريض عنده history of
+
+215
+00:17:59,830 --> 00:18:06,710
+alcohol drinking أو عنده liver disease بنعمل CBC و
+
+216
+00:18:06,710 --> 00:18:11,630
+blood film for
+
+217
+00:18:11,630 --> 00:18:15,250
+evidence of marrow disease ونشوف reticulocyte قلنا
+
+218
+00:18:15,250 --> 00:18:20,560
+بيصير في reticulocyteبنفحص ال B12 و الفوليك اي
+
+219
+00:18:20,560 --> 00:18:26,060
+كيميسي chemical technique و بنشوف liver function و
+
+220
+00:18:26,060 --> 00:18:32,020
+TSH اللي هو مراقبة مباشرة بال B12 و الفوليك acid
+
+221
+00:18:32,020 --> 00:18:38,720
+deficiency لكن بنمروا exam if cause in doubt يعني
+
+222
+00:18:38,720 --> 00:18:41,100
+إذا كان شكينا في
+
+223
+00:18:46,890 --> 00:18:53,390
+في فحص ال bone marrow ف you really have to know
+
+224
+00:18:53,390 --> 00:18:57,810
+the following شايفين ال schematic diagram هذا اللي
+
+225
+00:18:57,810 --> 00:19:01,630
+بيبين لي كيف نعرف نوع ال anemia اللي عند المريض
+
+226
+00:19:01,630 --> 00:19:08,470
+يعني بندور على ال MCV طبعا في hemoglobin واطي يعني
+
+227
+00:19:08,470 --> 00:19:15,070
+في anemia بندور على ال MCV و بنشوف إذا ال MCV
+
+228
+00:19:15,070 --> 00:19:21,580
+عاليةيبقى فيه macrocytic anemia وفي هذه الحلقة
+
+229
+00:19:21,580 --> 00:19:27,580
+نبحث عن ال B12 و ال folate و الله إذا واطين معناته
+
+230
+00:19:27,580 --> 00:19:31,280
+تشخصت الحالة و هي megaloplastic anemia إذا كان
+
+231
+00:19:31,280 --> 00:19:37,220
+normal طلعه يجب أن نبحث عن سبب واضح غالبا يكون فيه
+
+232
+00:19:37,220 --> 00:19:44,240
+أسباب أخرى زي ما سنشوف في ال kidney or liver or
+
+233
+00:19:44,240 --> 00:19:50,410
+thyroidإذا كان مش لاجي سبب واضح بدك تفحص البولمارو
+
+234
+00:19:50,410 --> 00:19:58,010
+وهذه الحالة النقيدة يوم يكون اللي هو فيه أنيميا
+
+235
+00:19:58,010 --> 00:20:09,510
+واطية وطلعناها ل MCV وجيناها واطية وطية
+
+236
+00:20:09,510 --> 00:20:10,990
+وطية وطية وطية وطية وطية وطية وطية وطية وطية وطية
+
+237
+00:20:10,990 --> 00:20:12,770
+وطية وطية وطية وطية وطية وطية وطية وطية وطية وطية
+
+238
+00:20:12,770 --> 00:20:12,810
+وطية وطية وطية وطية وطية وطية وطية وطية وطية وطية
+
+239
+00:20:12,810 --> 00:20:13,970
+وطية وطية وطية وطية وطية وطية وطية وطية وطية وطية
+
+240
+00:20:13,970 --> 00:20:13,970
+وطية وطية وطية وطية وطية وطية وطية وطية وطية وطية
+
+241
+00:20:13,970 --> 00:20:22,640
+وطية وطية وفيه أنيميا و ال MCV Normal معناته
+
+242
+00:20:22,640 --> 00:20:27,180
+نورموسيتك أنيميا بتدور على تيكلوسايد و الله إذا
+
+243
+00:20:27,180 --> 00:20:30,960
+high يعني high معناته hemolytic أنيميا و إذا low
+
+244
+00:20:30,960 --> 00:20:34,160
+بدك تدور على أسباب أخرى من ضمنها ال ACD و الrenal
+
+245
+00:20:34,160 --> 00:20:39,540
+failure و ال marrow failure و هذا الفيلم بيبينلي
+
+246
+00:20:39,540 --> 00:20:46,320
+ال normal blood filmعشان نشوف ال macro size شايفين
+
+247
+00:20:46,320 --> 00:20:52,380
+حجم ال macro size compared to normal discord RPCs
+
+248
+00:20:52,380 --> 00:20:58,460
+ده هي كبيرة وياش و تقريبا oval شايفين ال hyper
+
+249
+00:20:58,460 --> 00:21:03,570
+segmented بقولنا أحد الظواهر اللي بتؤثر علىبتتأثر
+
+250
+00:21:03,570 --> 00:21:06,390
+من الميجالو بلاستيك الانيميا ال white blood cell
+
+251
+00:21:06,390 --> 00:21:10,650
+فبتصير hyper segmented وطبعا ال hyper segmentation
+
+252
+00:21:10,650 --> 00:21:17,490
+دليل على ان الخلية اتخرت في ال bone marrow
+
+253
+00:21:17,490 --> 00:21:26,930
+وبالتالي طلعت انك hyper segmented هى برضه عبارة عن
+
+254
+00:21:26,930 --> 00:21:34,230
+normal blastلأنه في طلب على ال RBCs فبتطلع الخلايا
+
+255
+00:21:34,230 --> 00:21:39,650
+بدري هذه normal marrow cell ده في الوضع الطبيعي
+
+256
+00:21:39,650 --> 00:21:45,650
+وهي ال megaloplastic شايفين كده حجوم مختلفة ميجالو
+
+257
+00:21:45,650 --> 00:21:51,310
+بلاستيك مارو اللي كونه يشغل وقلة ال RBCs الارترويد
+
+258
+00:21:51,310 --> 00:21:55,670
+البركيرسال سيل برضه قليلة هذا ال giant
+
+259
+00:21:55,670 --> 00:22:00,930
+metamilositesاللي بتتمثل فيها ميجالو بلاستيك مارو
+
+260
+00:22:00,930 --> 00:22:08,070
+سيل وهذه أبراحان صورة بتمثل degeneration of dorsal
+
+261
+00:22:08,070 --> 00:22:12,310
+and lateral شايفين الهريان اللي موجود عوارين ال
+
+262
+00:22:12,310 --> 00:22:20,710
+spinal cord هذا طبعا بيؤدى الى demelanation in the
+
+263
+00:22:20,710 --> 00:22:27,820
+spinal cord وبالتالي محصولبتولد فولك أسد ديفشانسي
+
+264
+00:22:27,820 --> 00:22:33,720
+خليني ألخص اللي حكيناه قولنا ان هما الوضع مرتبط
+
+265
+00:22:33,720 --> 00:22:39,460
+بالميجالو بلاستيكانيميا الوضع
+
+266
+00:22:39,460 --> 00:22:40,720
+مرتبط بالميجالو بلاستيكانيميا الوضع مرتبط
+
+267
+00:22:40,720 --> 00:22:41,940
+بالميجالو بلاستيكانيميا الوضع مرتبط بالميجالو
+
+268
+00:22:41,940 --> 00:22:42,280
+بلاستيكانيميا الوضع مرتبط بالميجالو بلاستيكانيميا
+
+269
+00:22:42,280 --> 00:22:43,460
+الوضع مرتبط بالميجالو بلاستيكانيميا الوضع مرتبط
+
+270
+00:22:43,460 --> 00:22:45,980
+بالميجالو بلاستيكانيميا الوضع مرتبط بالميجالو
+
+271
+00:22:45,980 --> 00:22:50,200
+بلاستيكانيميا الوضع
+
+272
+00:22:50,200 --> 00:22:53,500
+مرتبط بالميجالو
+
+273
+00:22:53,500 --> 00:22:58,060
+بلاستيمن ال pholic acid و حوالى تلت سنية عشان نخلص
+
+274
+00:22:58,060 --> 00:23:06,020
+من ال B12 او ينجس عنا ال B12 و هذه فترات اللى
+
+275
+00:23:06,020 --> 00:23:16,500
+مخزونة فوليت موجودة in meat and vegetable قوة
+
+276
+00:23:16,500 --> 00:23:22,060
+بنمتصها في الجنة ال B12 موجود in animal source
+
+277
+00:23:22,820 --> 00:23:27,000
+وغالبا بيمتص في ال اليم وبيحتاج الى intrinsic
+
+278
+00:23:27,000 --> 00:23:34,140
+factor عشان يمتص fully deficiency result from poor
+
+279
+00:23:34,140 --> 00:23:37,640
+diet مع ال absorption and increase requirement
+
+280
+00:23:37,640 --> 00:23:43,560
+between deficiency غالبا ال common case فيها ال
+
+281
+00:23:43,560 --> 00:23:48,220
+pernicious anemia و ال pernicious anemia جاية من
+
+282
+00:23:48,220 --> 00:23:51,440
+autoimmune attack to the gastric parietal cell
+
+283
+00:23:53,410 --> 00:23:56,670
+والمحصة لأي كلورا هايدرا وانتنازينج فايتر
+
+284
+00:23:56,670 --> 00:24:01,730
+ديفيشانسي low vitamin B12 are common in elderly
+
+285
+00:24:01,730 --> 00:24:11,070
+people and usually they do not cause anemia كل
+
+286
+00:24:11,070 --> 00:24:17,190
+اللي بيعملونه they should manage by oral B12
+
+287
+00:24:17,190 --> 00:24:22,560
+replacement ديفيشانسي B12 and folic acidممكن
+
+288
+00:24:22,560 --> 00:24:26,900
+نشخصهم بقياس الهوموسيستين والميثيونين او مثلا
+
+289
+00:24:26,900 --> 00:24:31,940
+مالونيزك اسد كمان
+
+290
+00:24:31,940 --> 00:24:40,260
+ال full 8 ممكن يصير tablet يتاخد oral يجزدي لكن ال
+
+291
+00:24:40,260 --> 00:24:46,420
+vitamin b12 لازم عن طريق القبر لكن
+
+292
+00:24:46,420 --> 00:24:50,800
+high dose oral therapy also work for bolognese
+
+293
+00:24:50,800 --> 00:24:51,660
+anemia
+
+294
+00:24:54,300 --> 00:24:58,880
+عطيك كمية كبيرة من الأكل يعنى اللهم صلى ع سيدنا
+
+295
+00:24:58,880 --> 00:25:04,320
+محمد بس بالنسبالى كيفية تشخيص ان احنا بنقيص ال
+
+296
+00:25:04,320 --> 00:25:08,700
+folic acid والإيهاش والميثايل مالونيل بنقيص ال
+
+297
+00:25:08,700 --> 00:25:13,820
+homocystein والميثايل مالونيلك أسد طبعا كلكم
+
+298
+00:25:13,820 --> 00:25:17,320
+بتعرفوا انه يوم يكون فيه deficiency في ال vitamin
+
+299
+00:25:17,320 --> 00:25:32,380
+B12 ان folic acid هذه المركبات لاتنتج وتتحول
+
+300
+00:25:32,380 --> 00:25:36,820
+وبالتالي تزيد في الجسم شوية شوية عشان اذا فعصناها
+
+301
+00:25:36,820 --> 00:25:41,560
+نلاقيها عالية increase dietary folate intake in a
+
+302
+00:25:41,560 --> 00:25:45,860
+population lower its average level of serum
+
+303
+00:25:45,860 --> 00:25:47,040
+homocysteine
+
+304
+00:25:52,040 --> 00:25:56,940
+و غالبا ديالي دوز ممكن توصل ل maximum effect حوالي
+
+305
+00:25:56,940 --> 00:26:02,420
+400 ميكرو جرام انها ال two tube defect بنبطل
+
+306
+00:26:02,420 --> 00:26:07,200
+نشوفها اذا كان ال pregnant woman اخدت folate
+
+307
+00:26:07,200 --> 00:26:11,700
+supplement وهذه
+
+308
+00:26:11,700 --> 00:26:18,000
+الجدول بيفرقلي ما بين properties of folic acid and
+
+309
+00:26:18,000 --> 00:26:21,300
+B12 deficiency
+
+310
+00:26:27,060 --> 00:26:34,680
+زي ما انتوا شايفين في حالة الفولك أسد و
+
+311
+00:26:34,680 --> 00:26:39,200
+ال vitamin بتقل في جدول كامل بيفرق ليه بين التنتين
+
+312
+00:26:39,200 --> 00:26:43,800
+الفولك أسد almost كل الأكل موجود في كل الأكل بينما
+
+313
+00:26:43,800 --> 00:26:49,320
+ال vitamin بتقل فقط في المصادر الحيوانية التنين
+
+314
+00:26:49,320 --> 00:26:53,400
+they are water soluble هذا بيمتص الفولك أسد في
+
+315
+00:26:53,400 --> 00:26:58,640
+الددنة مهداك في ال heliumطريقة الانتصاف فولك أسد
+
+316
+00:26:58,640 --> 00:27:07,640
+الانتصاف الانتصاف
+
+317
+00:27:07,640 --> 00:27:08,560
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+318
+00:27:08,560 --> 00:27:09,720
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+319
+00:27:09,720 --> 00:27:11,180
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+320
+00:27:11,180 --> 00:27:11,180
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+321
+00:27:11,180 --> 00:27:11,180
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+322
+00:27:11,180 --> 00:27:11,220
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+323
+00:27:11,220 --> 00:27:11,240
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+324
+00:27:11,240 --> 00:27:17,360
+الانتصاف الانتصاف الانتصاف الانتصاف الانتصاف
+
+325
+00:27:21,940 --> 00:27:26,600
+المخازنة دي 4 على 5 شهور في ال folic acid بتكفي
+
+326
+00:27:26,600 --> 00:27:33,320
+لكن ال B12 بيكفينا مخزوننا من سنتين ل 12 سنة و دي
+
+327
+00:27:33,320 --> 00:27:39,280
+طبعا كل نسبة بتختلف باختلاف المراجعةوهكذا الحاجة
+
+328
+00:27:39,280 --> 00:27:43,420
+اللى بتصير كمان ال neurological disease بنشوفه في
+
+329
+00:27:43,420 --> 00:27:50,740
+ال vitamin B12 ومش في ال folic acid وبهيك بنكون
+
+330
+00:27:50,740 --> 00:27:56,520
+أنهينا كل ما يتعلق بال folic acid and vitamin B12
+
+331
+00:27:56,520 --> 00:28:01,160
+deficiency أو بينجوسين ميجالو بلاستيك أنيميا
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b4429241f366fd40dab3380806a08657b2ed24b5
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM.srt
@@ -0,0 +1,1399 @@
+1
+00:00:01,640 --> 00:00:05,020
+بسم الله الرحمن الرحيم الصلاة والسلام على سيد
+
+2
+00:00:05,020 --> 00:00:13,580
+الخلق أجمعين سيدنا محمد وعلى آله وصحبه وسلم نلتقى 
+
+3
+00:00:13,580 --> 00:00:16,540
+اليوم في محاضرة جديدة بعنوان the non-leukemic
+
+4
+00:00:16,540 --> 00:00:22,000
+lymphoproliferative disorders و
+
+5
+00:00:22,000 --> 00:00:28,900
+these are malignant clonal disorders أيضا يعني على 
+
+6
+00:00:28,900 --> 00:00:33,630
+مستوى the stem cellولكن بمعنى Stem Cell of 
+
+7
+00:00:33,630 --> 00:00:39,330
+Lymphopoietic System وهذه المعلومات تحتوي على 
+
+8
+00:00:39,330 --> 00:00:42,130
+Multiple Myeloma Related Plasma Cell Disorders
+
+9
+00:00:42,130 --> 00:00:46,170
+وHodgkin Disease وNon Hodgkin Lymphoma ونبدأ بأول 
+
+10
+00:00:46,170 --> 00:00:50,990
+هذه الحالات المرضية التي هي Multiple Myeloma
+
+11
+00:00:50,990 --> 00:00:54,910
+Related Plasma Cell Disorders وتعريفا Multiple
+
+12
+00:00:54,910 --> 00:01:01,040
+Myeloma is a B lymphoid malignancy بماذا يتميز؟ هي 
+
+13
+00:01:01,040 --> 00:01:05,220
+تميز by proliferation of malignant clone of plasma 
+
+14
+00:01:05,220 --> 00:01:10,020
+cell كلنا بنعرف the plasma cell هي the
+
+15
+00:01:10,020 --> 00:01:16,100
+differentiated form of B cell لما تتطور الخلية 
+
+16
+00:01:16,100 --> 00:01:19,300
+بسلها proliferation and differentiation بينفسها 
+
+17
+00:01:19,300 --> 00:01:23,000
+تتحول ل plasma cell the multiple myeloma هو عبارة عن
+
+18
+00:01:23,000 --> 00:01:27,680
+proliferation of malignant clone من البلازمة cell
+
+19
+00:01:27,680 --> 00:01:31,180
+شو المظيفة the plasma cell secret excessive amount
+
+20
+00:01:31,180 --> 00:01:34,860
+of monoclonal immunoglobulin طب ليش monoclonal لأن 
+
+21
+00:01:34,860 --> 00:01:41,280
+هم clone of the same cell وبالتالي يفرزوا the same
+
+22
+00:01:41,280 --> 00:01:47,840
+antibody immunoglobulin they released طبعا with
+
+23
+00:01:47,840 --> 00:01:50,960
+respect to multiple myeloma it behaves as a solid
+
+24
+00:01:50,960 --> 00:01:51,440
+tumor
+
+25
+00:01:55,350 --> 00:02:00,270
+وبيسبق solid tumor formation prior involvement of
+
+26
+00:02:00,270 --> 00:02:03,290
+bone marrow يعني the bone marrow should be involved
+
+27
+00:02:03,290 --> 00:02:10,170
+before formation of solid tumor نبقى تلخيصا على 
+
+28
+00:02:10,170 --> 00:02:13,390
+السريع هي عبارة عن myeloid malignancy بتميز by
+
+29
+00:02:13,390 --> 00:02:16,050
+clonal malignant clone of plasma cell 
+
+30
+00:02:16,050 --> 00:02:19,910
+proliferation وmalignant clone of plasma cell كنا 
+
+31
+00:02:19,910 --> 00:02:23,280
+بنعرف the plasma cell وظيفتها secretion of
+
+32
+00:02:23,280 --> 00:02:26,660
+immunoglobulin. These plasma cells secret
+
+33
+00:02:26,660 --> 00:02:32,340
+excessive amount of monoclonal antibody and this 
+
+34
+00:02:32,340 --> 00:02:37,400
+multiple myeloma disease behaves as a solid tumor
+
+35
+00:02:37,400 --> 00:02:41,980
+لكن لازم يكون فيه في البداية prior involvement to 
+
+36
+00:02:41,980 --> 00:02:46,540
+bone marrow. the incidence قالوا هذا is a disease of
+
+37
+00:02:46,540 --> 00:02:53,420
+elderly the media يعيش فوق 62 سنةو it's more common
+
+38
+00:02:53,420 --> 00:02:58,260
+in black than in white و the disease shows slight 
+
+39
+00:02:58,260 --> 00:03:03,960
+excess incidence in male than female كالعادة path
+
+40
+00:03:03,960 --> 00:03:08,400
+of synergy يالوا وجود malignant proliferation of
+
+41
+00:03:08,400 --> 00:03:15,540
+plasma cell بيقدّي إلى انه يعمل خلل في أربع
+
+42
+00:03:15,540 --> 00:03:20,880
+اتجاهات مختلفة نمرا واحد في plasma cell 
+
+43
+00:03:20,880 --> 00:03:24,720
+proliferation هيصير فيه إحلال لل bone marrow cell
+
+44
+00:03:24,720 --> 00:03:31,000
+وبالتالي بيصير فيه marrow infiltration محصلته انه 
+
+45
+00:03:31,000 --> 00:03:34,220
+يصير pancytopemia يعني bone marrow failure
+
+46
+00:03:37,190 --> 00:03:41,130
+بيتميز بالانيميا والإنفكشن والبريدنج يبقى أول حاجة 
+
+47
+00:03:41,130 --> 00:03:44,270
+بيصير هو أنه بيصير فيه bone marrow failure نتيجة 
+
+48
+00:03:44,270 --> 00:03:49,590
+bone marrow infiltration بالبلازما سيل وبالتالي
+
+49
+00:03:49,590 --> 00:03:54,790
+بيصير في إحلال لل normal cell بplasma cell
+
+50
+00:03:54,790 --> 00:03:58,110
+الحاجة التانية قلنا إن these plasma cell or 
+
+51
+00:03:58,110 --> 00:04:03,470
+plasma cell secret اللي هو a huge amount of 
+
+52
+00:04:03,470 --> 00:04:08,740
+immunoglobulin وهذا الـ immunoglobulin طالع من الـ 
+
+53
+00:04:08,740 --> 00:04:14,700
+plasma cell يبقى should be abnormal وبما ان ال
+
+54
+00:04:14,700 --> 00:04:17,640
+immunoglobulin المنتج هو عبارة عن abnormal
+
+55
+00:04:17,640 --> 00:04:20,940
+immunoglobulin يمكن تحسر فيه reduction في or
+
+56
+00:04:20,940 --> 00:04:23,640
+decrease في ال amount of normal immunoglobulin
+
+57
+00:04:23,640 --> 00:04:29,660
+يبقى هذين دراعين الأولاني Bone marrow infiltration التاني هو
+
+58
+00:04:29,660 --> 00:04:31,880
+عبارة عن excessive amount of abnormal
+
+59
+00:04:31,880 --> 00:04:36,120
+immunoglobulinوهذا بيؤدي الى decrease amount of
+
+60
+00:04:36,120 --> 00:04:41,160
+normal immunoglobulin و الذراع الرابع والمهم هو 
+
+61
+00:04:41,160 --> 00:04:45,180
+بيصير فيه skeletal destruction تبدأ البون يتكسر
+
+62
+00:04:45,180 --> 00:04:51,460
+فبصير فيه lytic bone lesion و pathologic fracture
+
+63
+00:04:51,460 --> 00:05:00,820
+و hypercalcemia و palpable plasma cytoma Plasma
+
+64
+00:05:00,820 --> 00:05:06,000
+cytoma هو عبارة عن tumor mass of plasma cell و
+
+65
+00:05:06,000 --> 00:05:11,140
+هنجي لواحد واحد من كل هذه الحاجات نبدأ بأول هذه 
+
+66
+00:05:11,140 --> 00:05:14,520
+الحاجات وهي the lytic bone lesion لو the lytic
+
+67
+00:05:14,520 --> 00:05:21,280
+bone lesion ببدأ تقرحات في the bone و بتؤدي إلى
+
+68
+00:05:21,280 --> 00:05:26,150
+يعني تفتيت هذا the bone والسبب في ذلك أن
+
+69
+00:05:26,150 --> 00:05:29,030
+the malignant plasma cell بتؤدي إلى إنتاج 
+
+70
+00:05:29,030 --> 00:05:33,670
+the osteoclast activating factor وهذا الـ osteoclast
+
+71
+00:05:33,670 --> 00:05:37,290
+activating factor بتعرفي من الـ osteoclast وظيفة 
+
+72
+00:05:37,290 --> 00:05:42,610
+اسمه عبارة عن خلية آكلة العظم فالـ osteoclast
+
+73
+00:05:42,610 --> 00:05:44,950
+activating factor هو عبارة عن الـ factor اللي بيؤدي
+
+74
+00:05:44,950 --> 00:05:52,410
+إلى تفتيت العضم وأكلانه هذا سيقوم بالإضافة إلى
+
+75
+00:05:52,410 --> 00:06:02,210
+عملية 
+
+76
+00:06:02,210 --> 00:06:07,490
+عملية عملية عملية عملية عملية عملية عملية عملية 
+
+77
+00:06:07,490 --> 00:06:07,650
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+78
+00:06:07,650 --> 00:06:08,010
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+79
+00:06:08,010 --> 00:06:08,030
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+80
+00:06:08,030 --> 00:06:09,190
+عملية عملية عملية عملية عملية عملية عملية عملية
+
+81
+00:06:09,190 --> 00:06:13,710
+عملية عملية عملية عملية عملية 
+
+82
+00:06:13,710 --> 00:06:16,010
+عمل
+
+83
+00:06:17,950 --> 00:06:21,810
+with result of pain اكيد الواحد قاعد بتفتفت عضمه و
+
+84
+00:06:21,810 --> 00:06:27,910
+لازم يتألم و المحصلة pathologic fracture و في 
+
+85
+00:06:27,910 --> 00:06:31,970
+المحصلة bone بيتفتفت معناته و الbone بيتكون من 
+
+86
+00:06:31,970 --> 00:06:34,990
+calcium فبالتالي بيصير فيه زيادة في the serum
+
+87
+00:06:34,990 --> 00:06:39,470
+calcium concentration the hypercalcemia بحاجتها كان
+
+88
+00:06:39,470 --> 00:06:46,070
+inducing و بتعمل kidney stone وممكن في النهاية
+
+89
+00:06:46,070 --> 00:06:51,830
+تؤدي الى frank renal failure يعني المريض يعاني من
+
+90
+00:06:51,830 --> 00:06:57,370
+ايش؟ من the renal failure طيب هذا the analytic
+
+91
+00:06:57,370 --> 00:07:01,730
+religion نمرة اتنين over production of 
+
+92
+00:07:01,730 --> 00:07:06,590
+immunoglobulin احنا قولنا often an excess of large
+
+93
+00:07:06,590 --> 00:07:10,190
+chain طبعا هذا ما يميز the over production of 
+
+94
+00:07:10,190 --> 00:07:15,410
+immunoglobulin انه can be يعني diagnosed by excess
+
+95
+00:07:15,410 --> 00:07:19,690
+of light chain of immunoglobulin و the light
+
+96
+00:07:19,690 --> 00:07:25,610
+chain بيوفحص بواسطة او من خلال ما يسمى بال
+
+97
+00:07:25,610 --> 00:07:29,550
+Bence Jones protein the Bence Jones protein هو بره ان فحص 
+
+98
+00:07:29,550 --> 00:07:36,030
+انتوا أخدتوه في سوائل كيف يوفحص by boiling ناخد 
+
+99
+00:07:36,030 --> 00:07:40,540
+العينة بنغليها ده اربعين بصير فى تعكير فوق الاربعين
+
+100
+00:07:40,540 --> 00:07:45,700
+بتروح التعكير ارجع تانى بردها عند اربعين تحكر تانى
+
+101
+00:07:45,700 --> 00:07:54,080
+ثم بردها اكتر بتروح اللى هو the turbidity نمره 
+
+102
+00:07:54,080 --> 00:07:57,420
+اتنين يبقى the Bence Jones protein هو درع the diagnostic
+
+103
+00:07:57,420 --> 00:08:01,140
+tool نفحص 
+
+104
+00:08:01,140 --> 00:08:04,680
+من خلالها the over production of immunoglobulin نمره 
+
+105
+00:08:04,680 --> 00:08:08,500
+اتنين هذا viscosity طبعاً في انه high level of
+
+106
+00:08:08,500 --> 00:08:13,540
+immunoglobulin غريبا IgM وبعد مرة اخرى زي IgA و
+
+107
+00:08:13,540 --> 00:08:22,080
+IgG و لما بيزيدوا بيعملوا hyperviscosity ايضا هذه 
+
+108
+00:08:22,080 --> 00:08:26,740
+البروتينات ممكن تترسب في the renal tubules وتؤدي في
+
+109
+00:08:26,740 --> 00:08:31,820
+النهاية الى renal failure نمرة
+
+110
+00:08:31,820 --> 00:08:41,660
+اتنين او تلاتة مرة واحد تكون
+
+111
+00:08:41,660 --> 00:08:45,620
+the amyloid the amyloid the amyloid the amyloid the amyloid 
+
+112
+00:08:45,620 --> 00:08:48,980
+the amyloid the amyloid 
+
+113
+00:08:48,980 --> 00:08:50,380
+the amyloid the amyloid the amyloid the amyloid the amyloid
+
+114
+00:08:50,380 --> 00:08:51,700
+the amyloid the amyloid the amyloid the amyloid the amyloid
+
+115
+00:08:51,700 --> 00:08:51,980
+the amyloid the amyloid the amyloid the amyloid the amyloid
+
+116
+00:08:51,980 --> 00:08:53,880
+the amyloid the amyloid the amyloid the amyloid the amyloid
+
+117
+00:08:53,880 --> 00:08:56,440
+the amyloid the amyloid the amyloid the amyloid the amyloid
+
+118
+00:08:56,440 --> 00:09:04,620
+the amyloid the amyloid
+
+119
+00:09:06,710 --> 00:09:13,670
+و بتكوين rigid pleated fibrillar structure rigid
+
+120
+00:09:13,670 --> 00:09:18,170
+يعني صلب pleated حاد fibrillar من the fiber
+
+121
+00:09:18,170 --> 00:09:25,270
+structure طبعا هي ده تخيلوا عبارة عن عبارة عن 
+
+122
+00:09:25,270 --> 00:09:30,970
+سكاكين تمشي في ايش في the قوايا الدموية وبالتالي كل 
+
+123
+00:09:30,970 --> 00:09:37,700
+ما بتصل لأي عضو من أعضاء الجسم هناك بتعملدمج for 
+
+124
+00:09:37,700 --> 00:09:40,220
+these organs زي the kidneys زي the heart زي the 
+
+125
+00:09:40,220 --> 00:09:43,560
+liver زي the spleen زي the gastrointestinal tract 
+
+126
+00:09:43,560 --> 00:09:50,020
+او the tongue الغراء
+
+127
+00:09:50,020 --> 00:09:54,720
+التالت اللي بيأثر او تضرب فيه the plasma cell هو ال
+
+128
+00:09:54,720 --> 00:09:58,260
+expanding cell mass شو بيصير؟ يعني ال
+
+129
+00:09:58,260 --> 00:10:01,140
+proliferating myeloma cell the multiple myeloma
+
+130
+00:10:01,140 --> 00:10:04,910
+يعني plasma cell بيسموها myeloma cellماذا تفعل؟
+
+131
+00:10:04,910 --> 00:10:10,170
+بتحل المحل the normal Bone Marrow Cell وبتأدي هذا
+
+132
+00:10:10,170 --> 00:10:13,950
+الى Bone marrow failure فبصير فيه Anemia و بصير فيه 
+
+133
+00:10:13,950 --> 00:10:19,670
+Infection و بصير فيه Bleeding ايضا Expanding
+
+134
+00:10:19,670 --> 00:10:27,590
+the plasma cytoma can expand up to the limit that
+
+135
+00:10:27,590 --> 00:10:32,760
+impinge the spinal cord يعني بمعنى اخروالله هذه
+
+136
+00:10:32,760 --> 00:10:36,060
+الخلايا ممكن تدل تمشي لغاية ما تصل the central 
+
+137
+00:10:36,060 --> 00:10:42,220
+nervous system و هناك تعشش و تكون mass اللى ممكن 
+
+138
+00:10:42,220 --> 00:10:46,940
+تضغط على اللى هو the spinal cord على سبيل المثال و
+
+139
+00:10:46,940 --> 00:10:52,240
+بيبدأ المريض يفقد الإحساس ماشي و بيصير في عنده
+
+140
+00:10:52,240 --> 00:10:56,160
+incontinence يعني تقطيع في the بول و paraplegia
+
+141
+00:10:56,160 --> 00:11:07,710
+paraplegia يعني شلل، الشلل الرباعي ينتهي
+
+142
+00:11:07,710 --> 00:11:12,630
+إلى شلل رباعي، يبقى هي حاجتين، حاجة الأولانية bone
+
+143
+00:11:12,630 --> 00:11:15,870
+marrow failure، حاجة التانية ممكن يعمل plasma
+
+144
+00:11:15,870 --> 00:11:20,190
+cytoma يعني tumor of plasma cell اللي ممكن يكون في
+
+145
+00:11:20,190 --> 00:11:23,210
+الـ central nervous system ويؤدي إلى شلل، الحاجة
+
+146
+00:11:23,210 --> 00:11:29,330
+التالتة Myeloma cell ممكن تعمل 
+
+147
+00:11:29,330 --> 00:11:32,770
+organ infiltration، تغزو بعض الأعضاء زي الـ liver,
+
+148
+00:11:32,910 --> 00:11:36,410
+spleen و الـ kidney، بيؤدي هذا إلى enlargement of
+
+149
+00:11:36,410 --> 00:11:42,150
+this organ و المحصلة dysfunctional لهذه الـ organ
+
+150
+00:11:42,150 --> 00:11:47,430
+الـ fourth، زراعة باعضو هو decrease production من
+
+151
+00:11:47,430 --> 00:11:53,310
+normal immunoglobulin طبيعي، جدامافيش .. كل اللي
+
+152
+00:11:53,310 --> 00:11:55,810
+بيمتج هو عبارة عن abnormal immunoglobulin، فمافيش
+
+153
+00:11:55,810 --> 00:12:00,330
+normal immunoglobulin، وهذا محصلته زيادة في الـ
+
+154
+00:12:00,330 --> 00:12:06,650
+bacteria infection و infection mostly can cause
+
+155
+00:12:06,650 --> 00:12:10,610
+death، في بعض الأحيان، إضافة إلى ذلك cellular
+
+156
+00:12:10,610 --> 00:12:16,990
+immunity is not affected، لكن الـ cell mediated هو
+
+157
+00:12:16,990 --> 00:12:24,230
+الذي يتأثر، زي الفيروس والفنجاي والأسد فاست الانسان
+
+158
+00:12:24,230 --> 00:12:28,910
+هذه الانسان لم تتجمد
+
+159
+00:12:31,580 --> 00:12:34,640
+السلم الهيتيد لا تتأثر، كل اللي بيتأثر هو الـ
+
+160
+00:12:34,640 --> 00:12:38,260
+Humoral Immunity، الـ Humoral Immunity وهو تكوين
+
+161
+00:12:38,260 --> 00:12:41,820
+الـ Antibody بينما السلم الهيتيد اللي بيتعلق بالـ
+
+162
+00:12:41,820 --> 00:12:45,980
+T-Lymphocytes اللي مسؤول عن زي الـ T-Cytotoxic عن
+
+163
+00:12:45,980 --> 00:12:49,920
+التخلص من الفيروس و الفنجار الاسد في اصل الورجانزم
+
+164
+00:12:49,920 --> 00:12:55,180
+هذا لن يكون مؤثر، كلمة
+
+165
+00:12:55,180 --> 00:12:56,980
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+166
+00:12:56,980 --> 00:12:59,140
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+167
+00:12:59,140 --> 00:12:59,160
+كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة كلمة
+
+168
+00:12:59,160 --> 00:13:03,950
+كلمة كلمة كلمة كلمة، نمرة اتنين weakness and fatigue
+
+169
+00:13:03,950 --> 00:13:08,430
+لأنه فيه أنيميا، نمرة ثلاثة serious infection، فيه
+
+170
+00:13:08,430 --> 00:13:12,330
+نيوتروبينيا، نمرة أربعة renal failure، قبعا
+
+171
+00:13:12,330 --> 00:13:20,040
+Hypercalcemia، نمرة خمسة bleeding diathesis، لأنه
+
+172
+00:13:20,040 --> 00:13:24,960
+في حاجتين بتصير الآن بالنسبة للـ Hemostasis هنذكرهم
+
+173
+00:13:24,960 --> 00:13:29,040
+حوالانية في thrombocytopenia أو platelet
+
+174
+00:13:29,040 --> 00:13:35,040
+dysfunction وكمان ايش
+
+175
+00:13:35,040 --> 00:13:38,020
+اسمه كمان في اللي هو coagulation factor
+
+176
+00:13:38,020 --> 00:14:44,800
+dysfunction laboratory function أو laboratory test
+
+177
+00:13:45,100 --> 00:13:52,260
+ESR ممكن تكون أكثر من مية، الانيميا 
+
+178
+00:13:52,260 --> 00:13:56,560
+وThrombocytopenia واضحة، عملنا peripheral blood
+
+179
+00:13:56,560 --> 00:14:00,840
+باللي هي low formation لإنه فيه hyperviscosity و
+
+180
+00:14:00,840 --> 00:14:04,420
+الـ marrow plasma cytosis في الـ bone marrow، فيه
+
+181
+00:14:04,420 --> 00:14:09,300
+أكثر من عشر لـ 15% plasma cell، ثم hyperproteinemia
+
+182
+00:14:09,300 --> 00:14:13,320
+لأنه فيه monoclonal immunoglobulin، hypercalcemia في bone lytic
+
+183
+00:14:13,320 --> 00:14:17,380
+bones، بروتين اليوريا في بنجونز، البروتين في
+
+184
+00:14:17,380 --> 00:14:23,060
+azothemia اللي هو في أمونيا لإنه في الـrenal
+
+185
+00:14:23,060 --> 00:14:26,740
+failure، الـderematic
+
+186
+00:14:26,740 --> 00:14:29,260
+criteria for multiple myeloma كانوا في major
+
+187
+00:14:29,260 --> 00:14:33,140
+criteria وفي minor criteria، ايش الـ major criteria؟
+
+188
+00:14:33,140 --> 00:14:36,720
+كانت الـ plasma cytoma، وانطشوا بيبسي كانت عبارة عن
+
+189
+00:14:36,720 --> 00:14:41,300
+major criteria، ثم بيعملوا plasma cell لأكثر من 30%
+
+190
+00:14:42,310 --> 00:14:45,910
+هذه علامة أخرى من علامات الـ Major Criteria، ثم من
+
+191
+00:14:45,910 --> 00:14:50,750
+أقلنا الـ M Spike on Electrophoresis، ماذا يعني M
+
+192
+00:14:50,750 --> 00:14:54,610
+Spike؟ كنا نعرف أن البروتين Electrophoresis هو
+
+193
+00:14:54,610 --> 00:15:00,890
+عبارة عن ألبومين، وبياخد بيك عالية ثم Alpha-1
+
+194
+00:15:00,890 --> 00:15:09,170
+وAlpha-2 وGamma، Alpha-1 وAlpha-2 وBeta ثم Gamma
+
+195
+00:15:09,170 --> 00:15:11,710
+Globulin
+
+196
+00:15:13,340 --> 00:15:17,300
+وهي في الـ Gamma Globulin بيكون موجود الـ
+
+197
+00:15:17,300 --> 00:15:20,960
+Immunoglobulin، فبما أننا بنحكي على كمية كبيرة من
+
+198
+00:15:20,960 --> 00:15:24,040
+الـ Immunoglobulin هيكون برضه فيه Peak عالية من
+
+199
+00:15:24,040 --> 00:15:30,220
+ايش؟ من الجامعة، ففي قلب من الـ Peak عالية بيسموها
+
+200
+00:15:30,220 --> 00:15:36,320
+Spike، Spike يعني شوكة، وفي Peak تانية من الجامعة
+
+201
+00:15:36,320 --> 00:15:45,110
+فالتنتير مع بعض بيعملوا شكل الـ Mلتر، فبسموه M
+
+202
+00:15:45,110 --> 00:15:49,770
+spikes، طبعا تركيز الـ الـ immunoglobulin زي ما أنتو
+
+203
+00:15:49,770 --> 00:15:55,290
+شايفين كلها واطية، IGG
+
+204
+00:15:55,290 --> 00:16:01,090
+ثلاثة و نص جرام، اه
+
+205
+00:16:01,090 --> 00:16:05,010
+ده في الـ في الـ urine sample، طبعا هدا احنا بنقول في
+
+206
+00:16:05,010 --> 00:16:13,700
+low level of normal وhigh level of abnormal، هدا كله
+
+207
+00:16:13,700 --> 00:16:19,180
+level of abnormal للمينوكروابينان، طب ومعناه الـ
+
+208
+00:16:19,180 --> 00:16:22,760
+criteria، يعني الـ bone marrow plasma سل من عشر
+
+209
+00:16:22,760 --> 00:16:26,760
+لتلاتين، يعني أقل من تلاتين، ولأما spike موجودة
+
+210
+00:16:26,760 --> 00:16:30,580
+لكنها أقل من اللي فوق، ثم lytic bone lesion، ثم
+
+211
+00:16:30,580 --> 00:16:36,510
+normal IgM أقل من خمسين، IGE أقل من 100، IGG أقل من
+
+212
+00:16:36,510 --> 00:16:59,650
+600 IGG
+
+213
+00:16:59,650 --> 00:17:01,690
+أقل من 600 IGG أقل من 600 IGG أقل من 600 IGG أقل
+
+214
+00:17:01,690 --> 00:17:02,130
+من 600 IGG أقل من 600 IGG أقل من 600 IGG أقل
+
+215
+00:17:02,130 --> 00:17:02,310
+من 600 IGG أقل من 600 IGG أقل من 600 IGG أقل
+
+216
+00:17:02,310 --> 00:17:02,410
+600 IGG أقل من 600 IGG أقل من 600 IGG أقل من 600
+
+217
+00:17:02,410 --> 00:17:02,530
+IGG أقل من 600 IGG أقل من 600 IGG أقل من 600 IGG
+
+218
+00:17:02,530 --> 00:17:08,660
+من 600 أو اتنين مع B و اتنين مع C و اتنين مع D، هذه
+
+219
+000:17:08,660 --> 00:17:12,600
+عبارة عن Diagnostic Criteria، يوم يبقى تلاتة مع A
+
+220
+00:17:12,600 --> 00:17:20,220
+تلاتة مع C، تلاتة مع D، ايضا طبعا واحد و اتنين تلاتة
+
+221
+00:17:20,220 --> 00:17:26,700
+من الـ Major Criteria أو A B وC Major من اللي هو
+
+222
+00:17:26,700 --> 00:17:29,020
+Minor Criteria
+
+223
+00:17:31,830 --> 00:17:36,650
+الحصول على ميلومات مختلفة في مستوى الهيموغلابين
+
+224
+00:17:36,650 --> 00:17:45,690
+سيرام كالسيوم، ميموغلابيلين، وليس هناك لتك بين ليجين
+
+225
+00:17:45,690 --> 00:17:48,870
+هذا
+
+226
+00:17:48,870 --> 00:17:56,230
+سيشير إلى ميلومات مخطوطة ومتوقعية، فقسموا الميلومة
+
+227
+00:17:56,230 --> 00:17:59,090
+إلى عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+228
+00:17:59,090 --> 00:18:01,510
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+229
+00:18:01,510 --> 00:18:01,570
+عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد
+
+230
+00:18:01,570 --> 00:18:04,840
+عدد عدد عدد عدد عدد عدد عدد عدد عددto the myeloma
+
+231
+00:18:04,840 --> 00:18:10,520
+cell، طبعا في sub classification للمرض يالو
+
+232
+00:18:10,520 --> 00:18:13,740
+according to the kidney function، فإذا الكرياتين
+
+233
+00:18:13,740 --> 00:18:16,960
+أكثر من اتنين أو كرياتين أكثر من اتنين برضه هذا
+
+234
+00:18:16,960 --> 00:18:20,860
+عبارة عن sub classification، يبقى الـ clinical
+
+235
+00:18:20,860 --> 00:18:24,660
+staging تعتمد على الـ hemoglobin و الـ serum calcium
+
+236
+00:18:24,660 --> 00:18:28,560
+و الـ immunoglobulin، وجود lithic bone lesion ولا لأ
+
+237
+00:18:28,560 --> 00:18:35,100
+ثم حاجة تانية بيقسموها according to the ash to the
+
+238
+00:18:35,100 --> 00:18:39,960
+myeloma mass
+
+239
+00:18:39,960 --> 00:18:44,060
+فإذا كان فيه low tumor mass أو intermediate أو
+
+240
+00:18:44,060 --> 00:18:47,100
+high، و الـ some classification بناء على الـ kidney
+
+241
+00:18:47,100 --> 00:18:51,440
+functions و كان برهيطينين أقل من اتنين أو أكثر من
+
+242
+00:18:51,440 --> 00:18:55,140
+اتنين، poor diagnosis، وقت ايش يعني إذا كان فيه
+
+243
+00:18:55,140 --> 00:19:00,420
+cytogenetical abnormalities في كرمزوم واحد احداشر
+
+244
+00:19:00,420 --> 00:19:05,540
+وتلاتاشرأو إذا كان بيتا تو مايكرو غلابي لإن أكثر
+
+245
+00:19:05,540 --> 00:19:11,420
+من اتنين و نص مايكرو جرام لكل ملي، بيتا تو مايكرو
+
+246
+00:19:11,420 --> 00:19:16,660
+غلابي لإن هو قدر عنه من أنواع الـ protein اللي برضه
+
+247
+00:19:16,660 --> 00:19:21,840
+بيكون موجود في الـ .. في الـ myeloma multiple
+
+248
+00:19:21,840 --> 00:19:26,560
+myeloma disease treatment، في الوقت الحالي there is
+
+249
+00:19:26,560 --> 00:19:30,320
+no curative therapy لكن بيعالج المريض
+
+250
+00:19:30,320 --> 00:19:34,680
+symptomatically، يعني بيخففه من الـ symptoms كيف؟
+
+251
+00:19:34,680 --> 00:19:38,720
+بينقلوا دم إذا كان فيه أنيميا، وبعتوا antibiotic
+
+252
+00:19:38,720 --> 00:19:43,380
+إذا فيه infection، وبعملوا local radiotherapy إذا
+
+253
+00:19:43,380 --> 00:19:48,400
+فيه osteolytic bone، بيعملوا radiotherapy للـ bone
+
+254
+00:19:48,400 --> 00:19:53,280
+نفسه، وبعملوا dialysis for renal failure، وبعتوا
+
+255
+00:19:53,280 --> 00:19:57,960
+chemotherapy اللي هو الـ generating agent، عشان اللي
+
+256
+00:19:57,960 --> 00:20:04,240
+هو يعمل pain relief، يخفف الألم، لكن الـ response
+
+257
+00:20:04,240 --> 00:20:10,620
+للأسف الشديد for this drug is slow، هذا ما يتعلق
+
+258
+00:20:10,620 --> 00:20:14,860
+بالـ multiple myeloma، احنا قلنا هاه بنواة multiple
+
+259
+00:20:14,860 --> 00:20:18,460
+myeloma and plasma cell related plasma cell
+
+260
+00:20:18,460 --> 00:20:21,640
+disorders نحكي على مرة تانية اللي هي علاقة بالـ
+
+261
+00:20:21,640 --> 00:20:26,100
+Plasma Cell Disorder، This disease is called
+
+262
+00:20:26,100 --> 00:20:31,980
+Waldenström's Macroglobulinemia، اسم العالم
+
+263
+00:20:31,980 --> 00:20:37,300
+Waldenström's، وهي بيصير فيه macro يعني زيادة في الـ
+
+264
+00:20:37,300 --> 00:20:44,220
+Globulinemia في الـ Globulin portion، ايش الـ
+
+265
+00:20:44,220 --> 00:20:46,780
+Waldenström's Macroglobulinemia ده اللي هو بقى الـ
+
+266
+00:20:46,780 --> 00:20:51,310
+uncommon really يعني هو غير معروف بشكل عام، مليون
+
+267
+00:20:51,310 --> 00:20:55,270
+فويد دي سوردرز بيتميز بالـ Hyperviscosity والسبب
+
+268
+00:20:55,270 --> 00:20:58,670
+في ذلك Excessive secretion of monoclonal IgM
+
+269
+00:20:58,670 --> 00:21:04,410
+immunoglobulin by malignant clone، هنا الخلايا هي
+
+270
+00:21:04,410 --> 00:21:08,530
+عبارة عن malignant clone لكنها بتفرز one type of
+
+271
+00:21:08,530 --> 00:21:12,190
+immunoglobulin وهو الـ IgM، كنا بنعرف أن الـ IgM هو
+
+272
+00:21:12,190 --> 00:21:16,900
+أكبر أنواع الـ immunoglobulin، بشكل أو بيعمل الـ
+
+273
+00:21:16,900 --> 00:21:21,360
+Hyperviscosity أسرع من الـ Multimilona، الممكن تعطي
+
+274
+00:21:21,360 --> 00:21:26,640
+أكثر من نوع من الـ Immunoproblem، الأسباب
+
+275
+00:21:26,640 --> 00:21:32,140
+جاله بيصير في loss of regulation of a clone of
+
+276
+00:21:32,140 --> 00:21:38,140
+cell، وطبعا وين بيصير في loss of regulation، جاله
+
+277
+00:21:38,140 --> 00:21:41,240
+في انتقال الخلية من الـ B-Lymphocyte لبلازما cell
+
+278
+00:21:41,240 --> 00:21:46,930
+بتمر الخلية في مرحلة وساطية ماشي، وعند هذه المرحلة
+
+279
+00:21:46,930 --> 00:21:51,270
+بيجي في الـ regulation لتصل إلى الـ plasma cell
+
+280
+00:21:51,270 --> 00:21:56,450
+فالخلية هي عبارة عن خلية وسط ما بين الـ B 
+
+281
+00:21:56,450 --> 00:21:59,470
+lymphocyte وما بينها **و** ال plasma cell it's a
+
+282
+00:21:59,470 --> 00:22:02,630
+malignant form it's an immature cell و بيسموها
+
+283
+00:22:02,630 --> 00:22:08,610
+lymphoplasma cytoid cell و هي خلية وسط ما بينها **و**
+
+284
+00:22:08,610 --> 00:22:11,530
+بين ال B lymphocyte و ال plasma cell incidence
+
+285
+00:22:11,530 --> 00:22:15,080
+يعني هو عبارة عن disease of the **bone marrow** with a peak
+
+286
+00:22:15,080 --> 00:22:19,600
+incidence في ال seventh decade يعني في العقد
+
+287
+00:22:19,600 --> 00:22:26,420
+السابع من العمر و أيضا لا يوجد اللي هو فرق في ال
+
+288
+00:22:26,420 --> 00:22:29,840
+incidence ما بين ال male و ال female بيقولوا life
+
+289
+00:22:29,840 --> 00:22:33,300
+expectancy لهذا المرض من تمام شهور ل تمام سنوات
+
+290
+00:22:33,300 --> 00:22:36,980
+symptoms weight loss
+
+291
+00:22:45,870 --> 00:22:50,070
+Lymphadenopathy ايضاً وBruising or bleeding لأن
+
+292
+00:22:50,070 --> 00:22:55,810
+الـ Platelet مش شغالة A long history of vague
+
+293
+00:22:55,810 --> 00:22:59,930
+weakness, fatigue and weight loss يعني بتمر فترة
+
+294
+00:22:59,930 --> 00:23:02,690
+طويلة جدا طبعا due to Anemia في هذه الحالة
+
+295
+00:23:02,690 --> 00:23:07,390
+Hyperviscosity Syndrome ليش؟ **لأن** جاروا ماليجنانت كلون
+
+296
+00:23:07,390 --> 00:23:12,810
+بصير له infiltration and accumulation of monoclonal
+
+297
+00:23:12,810 --> 00:23:17,850
+immunoglobulin هو بيعمل اللي هو malignant
+
+298
+00:23:17,850 --> 00:23:19,910
+infiltration او accumulation of malignant
+
+299
+00:23:19,910 --> 00:23:25,550
+monoclonal immunoglobulin clinical symptoms
+
+300
+00:23:25,550 --> 00:23:29,890
+accumulation of IgM ممكن يؤدي الى ال clinical
+
+301
+00:23:29,890 --> 00:23:34,310
+symptoms القاتلة نبرأ واحد neurological symptoms
+
+302
+00:23:34,310 --> 00:23:40,180
+زي ال headacheوالـ Vertigo والضعف العام And in
+
+303
+00:23:40,180 --> 00:23:45,340
+severe cases كومة بيصير فيه unconsciousness يعني
+
+304
+00:23:45,340 --> 00:23:52,920
+ثم visual disturbances بيصير فيه خلل في الرؤية وثم
+
+305
+00:23:52,920 --> 00:23:56,800
+في ذلك secondary to retinal hemorrhage بيصير فيه
+
+306
+00:23:56,800 --> 00:24:03,040
+hemorrhage يعني نزيف في الشمكية و **أدمة** وهذا ممكن
+
+307
+00:24:03,040 --> 00:24:05,380
+يؤدي إلى permanent blindness
+
+308
+00:24:07,500 --> 00:24:13,420
+ثم cardiac failure and this is severe by the
+
+309
+00:24:13,420 --> 00:24:16,920
+increase in plasma viscosity طبعا بيصير blood
+
+310
+00:24:16,920 --> 00:24:20,860
+viscous بالتالي القلب يشتغل زيادة عن نزوله و بيصل
+
+311
+00:24:20,860 --> 00:24:26,020
+لمرحلة انه بيبدأ يضعف شوية شوية القلب platelet
+
+312
+00:24:26,020 --> 00:24:30,120
+dysfunction ليش؟ قالوا لأنه والله ال
+
+313
+00:24:30,120 --> 00:24:34,960
+immunoglobulin بيعمل coating للبلتلت فبتبطل شغالة
+
+314
+00:24:36,660 --> 00:24:41,060
+والتحركات الهيموستاتيكية أيضًا تتعامل مع الانهيبشن
+
+315
+00:24:41,060 --> 00:24:46,260
+من **fibrin** polymerization وفاكتوره تمانية activity by
+
+316
+00:24:46,260 --> 00:24:52,580
+monoclonal IgM مستشار يجد نورموسيتيك نورموكروميك
+
+317
+00:24:52,580 --> 00:24:58,220
+أنيميا وهذا أبر طبيعي لأن هناك إريثروبويسيس
+
+318
+00:24:58,220 --> 00:25:03,000
+suppression by malignant cloneولا **ي** Formation لإنه
+
+319
+00:25:03,000 --> 00:25:06,560
+فيه Hyperviscosity، Chronic bleeding لإنه
+
+320
+00:25:06,560 --> 00:25:12,120
+**caused** by the increased plasma volume ثم ال
+
+321
+00:25:12,120 --> 00:25:17,360
+white blood cell may be normal or depressed لكن
+
+322
+00:25:17,360 --> 00:25:24,370
+فيه relative lymphocytosis في **It** is common that it
+
+323
+00:25:24,370 --> 00:25:28,490
+counts as normal at presentation عند التشخيص.
+
+324
+00:25:28,590 --> 00:25:31,330
+However, neutropenia and thrombocytopenia become
+
+325
+00:25:31,330 --> 00:25:36,610
+more severe as the disease progresses. However,
+
+326
+00:25:36,690 --> 00:25:39,350
+cellular and extremely hyperviscous bone marrow
+
+327
+00:25:39,350 --> 00:25:42,550
+وهذا
+
+328
+00:25:42,550 --> 00:25:48,060
+مما يجعلعملية سحب عينات الـ bone marrow is
+
+329
+00:25:48,060 --> 00:25:53,620
+difficult مريجنانت سيل هي عبارة عن pleomorphic
+
+330
+00:25:53,620 --> 00:25:58,960
+يعني متعددة الأشكال مرات بنشوفها بتشبه ال
+
+331
+00:25:58,960 --> 00:26:03,720
+lymphocytes ومرات بنشوفها بتشبه ال plasma cell
+
+332
+00:26:03,720 --> 00:26:11,420
+however لكن it has an intermediate appearance و
+
+333
+00:26:11,420 --> 00:26:14,320
+بيسموها lymphoplasma cytoid
+
+334
+00:26:18,350 --> 00:26:21,750
+بيرونوسيز بيعتمد على ال pattern of infiltration
+
+335
+00:26:21,750 --> 00:26:25,450
+للملغنان تقلون في ال bone marrow كيف بيصلوا
+
+336
+00:26:25,450 --> 00:26:29,930
+infiltration و قسموه ل 3 حاجات اما diffuse
+
+337
+00:26:29,930 --> 00:26:32,510
+infiltration يعني كل ال bone marrow بيصله
+
+338
+00:26:32,510 --> 00:26:36,810
+diffusion diffuse by by by malignant cell and this
+
+339
+00:26:36,810 --> 00:26:41,130
+has a very poor prognosis و ال median survival
+
+340
+00:26:41,130 --> 00:26:46,630
+time حوالي 17 شهرModular infiltration نوع التاني
+
+341
+00:26:46,630 --> 00:26:51,310
+اللي هو الحلقي وغالبا it has a better prognosis ال
+
+342
+00:26:51,310 --> 00:26:55,550
+medium survival time 72 شهر ثم intermediate form
+
+343
+00:26:55,550 --> 00:27:01,230
+of infiltration بين الاتنين وهذا ممكن نشوف أشكال
+
+344
+00:27:01,230 --> 00:27:03,890
+ال modular وممكن نشوف ال diffuse infiltration مع
+
+345
+00:27:03,890 --> 00:27:11,050
+بعض وغالبا ال medium age حوالي 52 شهر treatment
+
+346
+00:27:11,050 --> 00:27:22,110
+symptomatic reliefبالتالي نحصل على بلازما فاريسز
+
+347
+00:27:22,110 --> 00:27:25,310
+من حيبرفسكاسيتي بنعمل debulking للبلازما البلازما
+
+348
+00:27:25,310 --> 00:27:30,230
+فيها ال immunoglobulin فبنقلل من الhyperviscosity
+
+349
+00:27:30,230 --> 00:27:36,360
+اللي بيسببها ال immunoglobulinإذا تطور المرض، يجب
+
+350
+00:27:36,360 --> 00:27:40,740
+أن نستخدم الـ Chemotherapy as a Treatment 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM_raw.json b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..dba3149b8a44e3737d2eacd609083cccb072e1b2
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/kZ-Q_tgUhuM_raw.json
@@ -0,0 +1 @@
+{"segments": [{"id": 1, "seek": 2998, "start": 1.64, "end": 29.98, "text": "بسم الله الرحمن الرحيم الصلاة والسلام على سيد الخلق أجمعين سيدنا محمد وعلى آله وصحبه وسلم نلتقى اليوم في محاضرة جديدة بعنوان the non-leukemic lymphoproliferative disorders و these are malignant clonal disorders أيضا يعني على مستوى الstem cell", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 31767, 15040, 3660, 16070, 3794, 37440, 15844, 8608, 25708, 33962, 1211, 4587, 5551, 7435, 2304, 3615, 9957, 8608, 25708, 8315, 3714, 35571, 3215, 4032, 3615, 23942, 19753, 43761, 4032, 9381, 5016, 3555, 3224, 46952, 19528, 8717, 1211, 2655, 4587, 7578, 45595, 20498, 8978, 3714, 5016, 46958, 25720, 10874, 16254, 41891, 45030, 1863, 2407, 7649, 264, 2107, 12, 306, 15420, 13195, 31070, 404, 6623, 9361, 1166, 20261, 4032, 613, 366, 2806, 36818, 596, 21523, 20261, 36632, 11242, 995, 37495, 22653, 15844, 3714, 14851, 2407, 7578, 2423, 1099, 2815], "avg_logprob": -0.1994200981769365, "compression_ratio": 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كالعادة path of synergy يالو وجود malignant proliferation of plasma cell بيقدّي إلى انه يعمل خلل في أربع اتجاهات مختلفة نمرا واحد في plasma cell proliferation", "tokens": [2407, 309, 311, 544, 2689, 294, 2211, 813, 294, 2418, 4032, 264, 4752, 3110, 4036, 9310, 41726, 294, 7133, 813, 6556, 9122, 6027, 3615, 18513, 3660, 3100, 295, 50163, 7251, 6027, 2407, 49610, 23328, 2806, 36818, 24398, 44987, 295, 22564, 2815, 4724, 1829, 28543, 11703, 1829, 30731, 16472, 3224, 7251, 25957, 1211, 16490, 1211, 1211, 8978, 5551, 25513, 3615, 1975, 2655, 7435, 40294, 9307, 3714, 46456, 46538, 3660, 8717, 2304, 23557, 36764, 24401, 8978, 22564, 2815, 24398, 44987], "avg_logprob": -0.29311708860759494, "compression_ratio": 1.4059829059829059, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 172.12, "end": 172.46, "word": "و", "probability": 0.45751953125}, {"start": 172.46, "end": 172.8, "word": " it's", "probability": 0.3312530517578125}, {"start": 172.8, "end": 173.08, "word": " more", 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marrow failure نتيجة bone marrow infiltration بالبلازما سيل وبالتالي بيصير في إحلال لل normal cell بlow chemical cell الحاجة التانية قلنا إن these low chemical cell or plasma cell secret اللي هو a huge amount of immunoglobul", "tokens": [3555, 36081, 2304, 1829, 11622, 20666, 7649, 32640, 25528, 16070, 28814, 1863, 5172, 4117, 8592, 1863, 16070, 3555, 16572, 3215, 1863, 7435, 7251, 3555, 4587, 7578, 5551, 12610, 11331, 26108, 3660, 4724, 1829, 9381, 13546, 31439, 14739, 3224, 4724, 1829, 9381, 13546, 8978, 3224, 9026, 47739, 7763, 8717, 31371, 7435, 3660, 9026, 47739, 29085, 2405, 20666, 3555, 15040, 11622, 15042, 8608, 26895, 46599, 6027, 2655, 6027, 1829, 4724, 1829, 9381, 13546, 8978, 11933, 5016, 1211, 6027, 24976, 2710, 2815, 4724, 752, 86, 7313, 2815, 21542, 26108, 3660, 16712, 7649, 10632, 12174, 1211, 8315, 36145, 613, 2295, 7313, 2815, 420, 22564, 2815, 4054, 13672, 1829, 31439, 257, 2603, 2372, 295, 13154, 45841, 12176], "avg_logprob": -0.38910398230088494, 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بيصير", "probability": 0.9677734375}, {"start": 229.91, "end": 230.07, "word": " في", "probability": 0.81787109375}, {"start": 230.07, "end": 230.69, "word": " إحلال", "probability": 0.88671875}, {"start": 230.69, "end": 231.07, "word": " لل", "probability": 0.68896484375}, {"start": 231.07, "end": 231.95, "word": " normal", "probability": 0.3857421875}, {"start": 231.95, "end": 232.31, "word": " cell", "probability": 0.96337890625}, {"start": 232.31, "end": 232.81, "word": " بlow", "probability": 0.3439534505208333}, {"start": 232.81, "end": 233.07, "word": " chemical", "probability": 0.413818359375}, {"start": 233.07, "end": 234.79, "word": " cell", "probability": 0.95263671875}, {"start": 234.79, "end": 235.77, "word": " الحاجة", "probability": 0.9674479166666666}, {"start": 235.77, "end": 236.17, "word": " التانية", "probability": 0.9345703125}, {"start": 236.17, "end": 236.57, "word": " قلنا", "probability": 0.7939453125}, {"start": 236.57, "end": 236.73, "word": " إن", 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"word": " leukemic", "probability": 0.6453857421875}, {"start": 249.16, "end": 249.38, "word": " cell", "probability": 0.93603515625}, {"start": 249.38, "end": 249.68, "word": " يبقى", "probability": 0.716827392578125}, {"start": 249.68, "end": 249.88, "word": " should", "probability": 0.07977294921875}, {"start": 249.88, "end": 250.16, "word": " be", "probability": 0.94921875}, {"start": 250.16, "end": 250.92, "word": " abnormal", "probability": 0.7919921875}, {"start": 250.92, "end": 253.14, "word": " وبما", "probability": 0.76318359375}, {"start": 253.14, "end": 253.4, "word": " ان", "probability": 0.464599609375}, {"start": 253.4, "end": 254.7, "word": " ال", "probability": 0.60986328125}, {"start": 254.7, "end": 255.82, "word": " immunoglobulin", "probability": 0.955078125}, {"start": 255.82, "end": 256.34, "word": " المنتج", "probability": 0.9275716145833334}, {"start": 256.34, "end": 256.48, "word": " هو", "probability": 0.8173828125}, {"start": 256.48, "end": 256.7, "word": " عبارة", "probability": 0.976806640625}, {"start": 256.7, "end": 256.9, "word": " عن", "probability": 0.97314453125}, {"start": 256.9, "end": 257.64, "word": " abnormal", "probability": 0.77587890625}, {"start": 257.64, "end": 258.46, "word": " immunoglobulin", "probability": 0.9801025390625}, {"start": 258.46, "end": 258.72, "word": " يمكن", "probability": 0.80859375}, {"start": 258.72, "end": 259.1, "word": " تحسر", "probability": 0.54730224609375}, {"start": 259.1, "end": 259.3, "word": " فيه", "probability": 0.638427734375}, {"start": 259.3, "end": 259.7, "word": " reduction", "probability": 0.9326171875}, {"start": 259.7, "end": 260.6, "word": " في", "probability": 0.6962890625}, {"start": 260.6, "end": 260.94, "word": " or", "probability": 0.6015625}, {"start": 260.94, "end": 261.54, "word": " decrease", "probability": 0.91455078125}, {"start": 261.54, "end": 261.7, "word": " في", "probability": 0.83984375}, {"start": 261.7, "end": 261.8, "word": " ال", "probability": 0.53125}, {"start": 261.8, "end": 262.1, "word": " amount", "probability": 0.9287109375}, {"start": 262.1, "end": 262.38, "word": " of", "probability": 0.96826171875}, {"start": 262.38, "end": 262.78, "word": " normal", "probability": 0.8173828125}, {"start": 262.78, "end": 263.64, "word": " immunoglobulin", "probability": 0.9798583984375}, {"start": 263.64, "end": 264.32, "word": " يبقى", "probability": 0.86041259765625}, {"start": 264.32, "end": 264.52, "word": " هذين", "probability": 0.53076171875}, {"start": 264.52, "end": 265.02, "word": " دراعين", "probability": 0.7584228515625}, {"start": 265.02, "end": 266.56, "word": " الأولاني", "probability": 0.905029296875}, {"start": 266.56, "end": 267.66, "word": " Bonmarofilian", "probability": 0.294189453125}, {"start": 267.66, "end": 269.12, "word": " التاني", "probability": 0.8006184895833334}, {"start": 269.12, "end": 269.66, "word": " هو", "probability": 0.92041015625}, {"start": 269.66, "end": 269.98, "word": " عبارة", "probability": 0.9951171875}, {"start": 269.98, "end": 270.18, "word": " عن", "probability": 0.99560546875}, {"start": 270.18, "end": 270.52, "word": " excessive", "probability": 0.83154296875}, {"start": 270.52, "end": 270.9, "word": " amount", "probability": 0.95361328125}, {"start": 270.9, "end": 271.26, "word": " of", "probability": 0.96923828125}, {"start": 271.26, "end": 271.88, "word": " abnormal", "probability": 0.83935546875}, {"start": 271.88, "end": 272.72, "word": " immunoglobulin", "probability": 0.977783203125}], "temperature": 1.0}, {"id": 11, "seek": 29808, "start": 273.1, "end": 298.08, "text": "وهذا بيؤدي الى decrease amount of normal immunoglobulin و الذراع الرابع والمهم هو بيصير فيه skeletal destruction تبدأ البون يتكسر فبصير فيه lithic bone lesion و pathologic fracture و hypercalcemia و palpable plasma cytoma", "tokens": [2407, 3224, 15730, 4724, 1829, 33604, 16254, 2423, 7578, 11514, 2372, 295, 2710, 13154, 45841, 12176, 259, 4032, 32545, 23557, 3615, 34892, 16758, 3615, 16070, 2304, 16095, 31439, 4724, 1829, 9381, 13546, 8978, 3224, 32321, 304, 13563, 6055, 44510, 10721, 29739, 11536, 7251, 2655, 4117, 3794, 2288, 6156, 3555, 9381, 13546, 8978, 3224, 26324, 299, 9026, 1512, 313, 4032, 3100, 36661, 36877, 4032, 9848, 9895, 26422, 654, 4032, 3984, 30454, 22564, 40248, 6440], "avg_logprob": -0.27618243726524144, "compression_ratio": 1.3798076923076923, "no_speech_prob": 2.384185791015625e-07, "words": [{"start": 273.1, "end": 273.54, "word": "وهذا", "probability": 0.7197265625}, {"start": 273.54, "end": 273.98, "word": " بيؤدي", "probability": 0.58038330078125}, {"start": 273.98, "end": 274.48, "word": " الى", "probability": 0.6728515625}, {"start": 274.48, "end": 275.14, "word": " decrease", "probability": 0.35498046875}, {"start": 275.14, "end": 275.72, "word": " amount", "probability": 0.787109375}, {"start": 275.72, "end": 276.12, "word": " of", "probability": 0.9599609375}, {"start": 276.12, "end": 276.86, "word": " normal", "probability": 0.7373046875}, {"start": 276.86, "end": 277.72, "word": " immunoglobulin", "probability": 0.94482421875}, {"start": 277.72, "end": 278.48, "word": " و", "probability": 0.66845703125}, {"start": 278.48, "end": 279.4, "word": " الذراع", "probability": 0.7347005208333334}, {"start": 279.4, "end": 279.9, "word": " الرابع", "probability": 0.9864908854166666}, {"start": 279.9, "end": 280.48, "word": " والمهم", "probability": 0.7660319010416666}, {"start": 280.48, "end": 281.16, "word": " هو", "probability": 0.9599609375}, {"start": 281.16, "end": 281.44, "word": " بيصير", "probability": 0.88330078125}, {"start": 281.44, "end": 281.64, "word": " فيه", "probability": 0.75732421875}, {"start": 281.64, "end": 282.16, "word": " skeletal", "probability": 0.96826171875}, {"start": 282.16, "end": 282.8, "word": " destruction", "probability": 0.89794921875}, {"start": 282.8, "end": 284.34, "word": " تبدأ", "probability": 0.6436767578125}, {"start": 284.34, "end": 284.56, "word": " البون", "probability": 0.3800048828125}, {"start": 284.56, "end": 285.18, "word": " يتكسر", "probability": 0.9705078125}, {"start": 285.18, "end": 287.28, "word": " فبصير", "probability": 0.785400390625}, {"start": 287.28, "end": 287.46, "word": " فيه", "probability": 0.864990234375}, {"start": 287.46, "end": 287.8, "word": " lithic", "probability": 0.642822265625}, {"start": 287.8, "end": 287.98, "word": " bone", "probability": 0.8388671875}, {"start": 287.98, "end": 288.48, "word": " lesion", "probability": 0.90380859375}, {"start": 288.48, "end": 289.84, "word": " و", "probability": 0.857421875}, {"start": 289.84, "end": 290.44, "word": " pathologic", "probability": 0.8154296875}, {"start": 290.44, "end": 291.46, "word": " fracture", "probability": 0.9599609375}, {"start": 291.46, "end": 293.1, "word": " و", "probability": 0.9423828125}, {"start": 293.1, "end": 294.62, "word": " hypercalcemia", "probability": 0.8427734375}, {"start": 294.62, "end": 296.2, "word": " و", "probability": 0.97314453125}, {"start": 296.2, "end": 296.8, "word": " palpable", "probability": 0.60302734375}, {"start": 296.8, "end": 297.42, "word": " plasma", "probability": 0.97265625}, {"start": 297.42, "end": 298.08, "word": " cytoma", "probability": 0.82958984375}], "temperature": 1.0}, {"id": 12, "seek": 32406, "start": 300.24, "end": 324.06, "text": "Plasma cytoma هو عبارة عن tumor mass of plasma cell و هنجي لواحد واحد من كل هذه الحاجات نبدأ بأول هذه الحاجات وهي ال lithic bone lesion لو ال lithic bone lesion ببدأ تقرحات في ال bone و بتؤدي إلى يعني تفتيت هذا ال bone", "tokens": [47, 7743, 1696, 40248, 6440, 31439, 6225, 3555, 9640, 3660, 18871, 22512, 2758, 295, 22564, 2815, 4032, 8032, 1863, 7435, 1829, 5296, 14407, 24401, 36764, 24401, 9154, 28242, 29538, 21542, 26108, 9307, 8717, 44510, 10721, 4724, 10721, 12610, 29538, 21542, 26108, 9307, 37037, 1829, 2423, 26324, 299, 9026, 1512, 313, 45164, 2423, 26324, 299, 9026, 1512, 313, 4724, 44510, 10721, 6055, 4587, 2288, 5016, 9307, 8978, 2423, 9026, 4032, 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{"start": 311.64, "end": 311.86, "word": " وهي", "probability": 0.87548828125}, {"start": 311.86, "end": 311.98, "word": " ال", "probability": 0.243408203125}, {"start": 311.98, "end": 312.28, "word": " lithic", "probability": 0.63916015625}, {"start": 312.28, "end": 312.44, "word": " bone", "probability": 0.79296875}, {"start": 312.44, "end": 312.88, "word": " lesion", "probability": 0.855224609375}, {"start": 312.88, "end": 314.1, "word": " لو", "probability": 0.75048828125}, {"start": 314.1, "end": 314.22, "word": " ال", "probability": 0.334228515625}, {"start": 314.22, "end": 314.52, "word": " lithic", "probability": 0.9873046875}, {"start": 314.52, "end": 314.68, "word": " bone", "probability": 0.8720703125}, {"start": 314.68, "end": 315.22, "word": " lesion", "probability": 0.90625}, {"start": 315.22, "end": 316.88, "word": " ببدأ", "probability": 0.7654622395833334}, {"start": 316.88, "end": 318.12, "word": " تقرحات", "probability": 0.93125}, {"start": 318.12, "end": 318.26, "word": " في", "probability": 0.94580078125}, {"start": 318.26, "end": 318.32, "word": " ال", "probability": 0.54052734375}, {"start": 318.32, "end": 318.6, "word": " bone", "probability": 0.77587890625}, {"start": 318.6, "end": 319.56, "word": " و", "probability": 0.61669921875}, {"start": 319.56, "end": 320.46, "word": " بتؤدي", "probability": 0.79150390625}, {"start": 320.46, "end": 321.28, "word": " إلى", "probability": 0.483154296875}, {"start": 321.28, "end": 322.74, "word": " يعني", "probability": 0.868408203125}, {"start": 322.74, "end": 323.48, "word": " تفتيت", "probability": 0.9298095703125}, {"start": 323.48, "end": 323.7, "word": " هذا", "probability": 0.97119140625}, {"start": 323.7, "end": 323.84, "word": " ال", "probability": 0.9658203125}, {"start": 323.84, "end": 324.06, "word": " bone", "probability": 0.9296875}], "temperature": 1.0}, {"id": 13, "seek": 34977, "start": 325.03, "end": 349.77, "text": "والسبب في ذلك أن الـmalignant plasma cell بتؤدي إلى إنتاج الـOsteoclast activating factor وهذا الـOsteoclast activating factor بتعرفي من الـOsteoclast وظيفة اسمه عبارة عن خدية آكلت العضم فالـOsteoclast activating factor هو عبارة عن الـfactor اللي بيؤدي إلى تفتيت العضم وأكلانه", "tokens": [2407, 6027, 35457, 3555, 8978, 29910, 23275, 14739, 2423, 39184, 5579, 36818, 22564, 2815, 39894, 33604, 16254, 30731, 11933, 29399, 26108, 2423, 39184, 46, 2941, 905, 15459, 42481, 5952, 37037, 15730, 2423, 39184, 46, 2941, 905, 15459, 42481, 5952, 39894, 3615, 28480, 1829, 9154, 2423, 39184, 46, 2941, 905, 15459, 4032, 19913, 33911, 3660, 24525, 2304, 3224, 6225, 3555, 9640, 3660, 18871, 16490, 3215, 10632, 19753, 28820, 2655, 18863, 11242, 2304, 6156, 6027, 39184, 46, 2941, 905, 15459, 42481, 5952, 31439, 6225, 3555, 9640, 3660, 18871, 2423, 39184, 69, 15104, 13672, 1829, 4724, 1829, 33604, 16254, 30731, 6055, 5172, 31371, 2655, 18863, 11242, 2304, 36725, 28820, 7649, 3224], "avg_logprob": -0.26304471055302053, "compression_ratio": 1.9047619047619047, 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بيصلوا", "probability": 0.62060546875}, {"start": 1585.45, "end": 1586.39, "word": " infiltration", "probability": 0.936279296875}, {"start": 1586.39, "end": 1587.23, "word": " و", "probability": 0.5849609375}, {"start": 1587.23, "end": 1588.67, "word": " قسموه", "probability": 0.45343017578125}, {"start": 1588.67, "end": 1588.75, "word": " ل", "probability": 0.8759765625}, {"start": 1588.75, "end": 1588.95, "word": " 3", "probability": 0.40185546875}, {"start": 1588.95, "end": 1589.37, "word": " حاجات", "probability": 0.9539388020833334}, {"start": 1589.37, "end": 1589.55, "word": " اما", "probability": 0.4176025390625}, {"start": 1589.55, "end": 1589.93, "word": " diffuse", "probability": 0.82568359375}, {"start": 1589.93, "end": 1590.71, "word": " infiltration", "probability": 0.869873046875}, {"start": 1590.71, "end": 1591.17, "word": " يعني", "probability": 0.905517578125}, {"start": 1591.17, "end": 1591.61, "word": " كل", "probability": 0.75830078125}, {"start": 1591.61, "end": 1591.77, "word": " ال", "probability": 0.75048828125}, {"start": 1591.77, "end": 1591.93, "word": " bone", "probability": 0.94482421875}, {"start": 1591.93, "end": 1592.15, "word": " marrow", "probability": 0.97216796875}, {"start": 1592.15, "end": 1592.51, "word": " بيصله", "probability": 0.8060302734375}, {"start": 1592.51, "end": 1593.03, "word": " diffusion", "probability": 0.85546875}, {"start": 1593.03, "end": 1594.29, "word": " diffuse", "probability": 0.19873046875}, {"start": 1594.29, "end": 1594.63, "word": " by", "probability": 0.81396484375}, {"start": 1594.63, "end": 1594.89, "word": " by", "probability": 0.2213134765625}, {"start": 1594.89, "end": 1595.37, "word": " by", "probability": 0.68505859375}, {"start": 1595.37, "end": 1595.99, "word": " ملغنان", "probability": 0.81171875}, {"start": 1595.99, "end": 1596.35, "word": " cell", "probability": 0.412841796875}, {"start": 1596.35, "end": 1596.57, "word": " and", "probability": 0.48583984375}, {"start": 1596.57, "end": 1596.81, "word": " this", "probability": 0.91455078125}, {"start": 1596.81, "end": 1597.37, "word": " has", "probability": 0.75537109375}, {"start": 1597.37, "end": 1597.65, "word": " a", "probability": 0.9267578125}, {"start": 1597.65, "end": 1597.85, "word": " very", "probability": 0.87353515625}, {"start": 1597.85, "end": 1598.25, "word": " poor", "probability": 0.951171875}, {"start": 1598.25, "end": 1599.31, "word": " prognosis", "probability": 0.8057454427083334}, {"start": 1599.31, "end": 1600.01, "word": " و", "probability": 0.60595703125}, {"start": 1600.01, "end": 1600.15, "word": " ال", "probability": 0.7587890625}, {"start": 1600.15, "end": 1600.43, "word": " median", "probability": 0.83740234375}, {"start": 1600.43, "end": 1601.13, "word": " survival", "probability": 0.93017578125}, {"start": 1601.13, "end": 1601.59, "word": " time", "probability": 0.8935546875}, {"start": 1601.59, "end": 1601.97, "word": " حوالي", "probability": 0.8720703125}, {"start": 1601.97, "end": 1602.35, "word": " 17", "probability": 0.82470703125}, {"start": 1602.35, "end": 1602.91, "word": " شهر", "probability": 0.98583984375}], "temperature": 1.0}, {"id": 60, "seek": 163425, "start": 1604.37, "end": 1634.25, "text": "Modular infiltration نوع التاني اللي هو الحلقي وغالبا it has a better prognosis ال medium survival time 72 شهر ثم intermediate form of infiltration بين الاتنين وهذا ممكن نشوف أشكال ال modular وممكن نشوف ال diffuse infiltration مع بعض وغالبا ال medium age حوالي 52 شهر treatment symptomatic relief", "tokens": [44, 378, 1040, 29085, 2405, 8717, 45367, 16712, 7649, 1829, 13672, 1829, 31439, 21542, 1211, 38436, 4032, 17082, 6027, 3555, 995, 309, 575, 257, 1101, 447, 4568, 8211, 2423, 6399, 12559, 565, 18731, 13412, 3224, 2288, 38637, 2304, 19376, 1254, 295, 29085, 2405, 49374, 2423, 9307, 1863, 9957, 37037, 15730, 3714, 43020, 8717, 8592, 38688, 5551, 8592, 4117, 6027, 2423, 31111, 4032, 2304, 43020, 8717, 8592, 38688, 2423, 42165, 29085, 2405, 20449, 45030, 11242, 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"probability": 0.1842041015625}, {"start": 1609.21, "end": 1609.81, "word": " has", "probability": 0.5556640625}, {"start": 1609.81, "end": 1609.93, "word": " a", "probability": 0.83642578125}, {"start": 1609.93, "end": 1610.15, "word": " better", "probability": 0.8095703125}, {"start": 1610.15, "end": 1610.85, "word": " prognosis", "probability": 0.8582356770833334}, {"start": 1610.85, "end": 1611.31, "word": " ال", "probability": 0.35498046875}, {"start": 1611.31, "end": 1611.49, "word": " medium", "probability": 0.42578125}, {"start": 1611.49, "end": 1612.01, "word": " survival", "probability": 0.94091796875}, {"start": 1612.01, "end": 1612.35, "word": " time", "probability": 0.82275390625}, {"start": 1612.35, "end": 1612.83, "word": " 72", "probability": 0.82958984375}, {"start": 1612.83, "end": 1613.41, "word": " شهر", "probability": 0.9690755208333334}, {"start": 1613.41, "end": 1614.29, "word": " ثم", "probability": 0.947509765625}, {"start": 1614.29, "end": 1615.05, "word": " intermediate", "probability": 0.9140625}, {"start": 1615.05, "end": 1615.55, "word": " form", "probability": 0.93212890625}, {"start": 1615.55, "end": 1615.93, "word": " of", "probability": 0.96826171875}, {"start": 1615.93, "end": 1616.65, "word": " infiltration", "probability": 0.982177734375}, {"start": 1616.65, "end": 1616.87, "word": " بين", "probability": 0.92919921875}, {"start": 1616.87, "end": 1617.49, "word": " الاتنين", "probability": 0.759368896484375}, {"start": 1617.49, "end": 1619.03, "word": " وهذا", "probability": 0.785400390625}, {"start": 1619.03, "end": 1619.39, "word": " ممكن", "probability": 0.94384765625}, {"start": 1619.39, "end": 1619.85, "word": " نشوف", "probability": 0.9724934895833334}, {"start": 1619.85, "end": 1621.23, "word": " أشكال", "probability": 0.9373779296875}, {"start": 1621.23, "end": 1621.35, "word": " ال", "probability": 0.53466796875}, {"start": 1621.35, "end": 1621.69, "word": " modular", "probability": 0.8671875}, {"start": 1621.69, "end": 1622.13, "word": " وممكن", "probability": 0.8421223958333334}, {"start": 1622.13, "end": 1622.41, "word": " نشوف", "probability": 0.99560546875}, {"start": 1622.41, "end": 1622.53, "word": " ال", "probability": 0.8369140625}, {"start": 1622.53, "end": 1622.89, "word": " diffuse", "probability": 0.912109375}, {"start": 1622.89, "end": 1623.63, "word": " infiltration", "probability": 0.972900390625}, {"start": 1623.63, "end": 1623.89, "word": " مع", "probability": 0.974609375}, {"start": 1623.89, "end": 1624.27, "word": " بعض", "probability": 0.981689453125}, {"start": 1624.27, "end": 1625.53, "word": " وغالبا", "probability": 0.9802734375}, {"start": 1625.53, "end": 1625.69, "word": " ال", "probability": 0.443359375}, {"start": 1625.69, "end": 1625.95, "word": " medium", "probability": 0.767578125}, {"start": 1625.95, "end": 1626.49, "word": " age", "probability": 0.9013671875}, {"start": 1626.49, "end": 1628.25, "word": " حوالي", "probability": 0.85076904296875}, {"start": 1628.25, "end": 1628.63, "word": " 52", "probability": 0.93701171875}, {"start": 1628.63, "end": 1629.83, "word": " شهر", "probability": 0.9930013020833334}, {"start": 1629.83, "end": 1631.05, "word": " treatment", "probability": 0.50390625}, {"start": 1631.05, "end": 1633.67, "word": " symptomatic", "probability": 0.8154296875}, {"start": 1633.67, "end": 1634.25, "word": " relief", "probability": 0.8779296875}], "temperature": 1.0}, {"id": 61, "seek": 165281, "start": 1635.75, "end": 1652.81, "text": "بالتالي نحصل على بلازما فاريسز من حيبرفسكاسيتي بنعمل debulking للبلازما البلازما فيها ال immunoglobulin فبنقلل من الhyperviscosity اللي بيسببها ال immunoglobulin", "tokens": [3555, 6027, 2655, 6027, 1829, 8717, 5016, 36520, 15844, 4724, 1211, 31377, 15042, 6156, 9640, 1829, 3794, 11622, 9154, 11331, 1829, 26890, 5172, 3794, 4117, 32277, 1829, 31371, 44945, 25957, 1211, 3001, 425, 5092, 24976, 3555, 1211, 31377, 15042, 29739, 1211, 31377, 15042, 8978, 11296, 2423, 13154, 45841, 12176, 259, 6156, 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1643.65, "word": " debulking", "probability": 0.6307169596354166}, {"start": 1643.65, "end": 1644.55, "word": " للبلازما", "probability": 0.660302734375}, {"start": 1644.55, "end": 1645.31, "word": " البلازما", "probability": 0.692230224609375}, {"start": 1645.31, "end": 1645.69, "word": " فيها", "probability": 0.82568359375}, {"start": 1645.69, "end": 1645.93, "word": " ال", "probability": 0.76416015625}, {"start": 1645.93, "end": 1646.85, "word": " immunoglobulin", "probability": 0.8560791015625}, {"start": 1646.85, "end": 1648.17, "word": " فبنقلل", "probability": 0.88232421875}, {"start": 1648.17, "end": 1648.49, "word": " من", "probability": 0.96533203125}, {"start": 1648.49, "end": 1650.23, "word": " الhyperviscosity", "probability": 0.5907389322916666}, {"start": 1650.23, "end": 1650.49, "word": " اللي", "probability": 0.760009765625}, {"start": 1650.49, "end": 1651.31, "word": " بيسببها", "probability": 0.93232421875}, {"start": 1651.31, "end": 1651.87, "word": " ال", "probability": 0.693359375}, {"start": 1651.87, "end": 1652.81, "word": " immunoglobulin", "probability": 0.95458984375}], "temperature": 1.0}, {"id": 62, "seek": 166074, "start": 1654.56, "end": 1660.74, "text": "إذا تطور المرض، يجب أن نستخدم الـ Chemotherapy as a Treatment", "tokens": [28814, 15730, 6055, 9566, 13063, 9673, 43042, 12399, 7251, 7435, 3555, 14739, 8717, 14851, 9778, 40448, 2423, 39184, 21357, 23208, 382, 257, 20298, 518], "avg_logprob": -0.5084374809265136, "compression_ratio": 0.9263157894736842, "no_speech_prob": 3.230571746826172e-05, "words": [{"start": 1654.56, "end": 1654.9, "word": "إذا", "probability": 0.545257568359375}, {"start": 1654.9, "end": 1655.46, "word": " تطور", "probability": 0.8974609375}, {"start": 1655.46, "end": 1656.08, "word": " المرض،", "probability": 0.7154947916666666}, {"start": 1656.08, "end": 1656.36, "word": " يجب", "probability": 0.6381429036458334}, {"start": 1656.36, "end": 1656.54, "word": " أن", "probability": 0.50244140625}, {"start": 1656.54, "end": 1657.08, "word": " نستخدم", "probability": 0.896240234375}, {"start": 1657.08, "end": 1657.26, "word": " الـ", "probability": 0.511962890625}, {"start": 1657.26, "end": 1657.82, "word": " Chemotherapy", "probability": 0.6669921875}, {"start": 1657.82, "end": 1659.28, "word": " as", "probability": 0.27490234375}, {"start": 1659.28, "end": 1659.64, "word": " a", "probability": 0.83837890625}, {"start": 1659.64, "end": 1660.74, "word": " Treatment", "probability": 0.756591796875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1666.6586875, "duration_after_vad": 1619.7099999999975}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4ed0975ca6b242dce70bd7ec36674e5541e041e0
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_postprocess.srt
@@ -0,0 +1,2992 @@
+1
+00:00:04,390 --> 00:00:10,130
+بسم الله الرحمن الرحيم اترفنا أولا في المحاضرة
+
+2
+00:00:10,130 --> 00:00:14,910
+السابقة على ال hemopoiesis و كيفية تصنيع الخلايا و
+
+3
+00:00:14,910 --> 00:00:20,590
+نبدأ الآن في بعض ال disorders متمثلة بأنواع مختلفة
+
+4
+00:00:20,590 --> 00:00:25,870
+من ال anemia و هنبدأ بال nutritional anemia يعني
+
+5
+00:00:25,870 --> 00:00:31,670
+ال anemia اللي ناتجة عن نقص في nutrition العوامل
+
+6
+00:00:31,670 --> 00:00:37,210
+الأكل يعنيو أشهر هذه الأنواع من ال anemia هي iron
+
+7
+00:00:37,210 --> 00:00:44,710
+deficiency anemia هنتفق على أسلوب شريح في هذا
+
+8
+00:00:44,710 --> 00:00:51,070
+الموضوع و هو ان
+
+9
+00:00:51,070 --> 00:00:53,670
+شاء الله احنا نتطرق لل chemistry of
+
+10
+00:00:56,630 --> 00:01:01,870
+عليه ثم من خلال ال chemistry هنتفهم دوره و نشوف
+
+11
+00:01:01,870 --> 00:01:07,210
+مواقع ال defect اللي بتصير وبالتالي مواقع الخلل
+
+12
+00:01:07,210 --> 00:01:15,250
+اللي بدها تنتج منها او عنها العنيميا الأشهر
+
+13
+00:01:15,250 --> 00:01:18,650
+هأ دى الأنواع زى ما قلتلكوا ال iron deficiency
+
+14
+00:01:18,650 --> 00:01:24,590
+عنيميا وبالتالي هنبدأ بال role of iron في الجسم
+
+15
+00:01:30,370 --> 00:01:34,970
+نبدأ على بركة الله وين موجود ال iron؟ ال iron
+
+16
+00:01:34,970 --> 00:01:39,510
+compound involved in cellular في موقعين مهمين موقع
+
+17
+00:01:39,510 --> 00:01:43,450
+الأولاني cellular metabolism يعني في الخلايا و
+
+18
+00:01:43,450 --> 00:01:48,090
+نشاط الخلايا و بالنجيم موجود في ال heme و ال iron
+
+19
+00:01:48,090 --> 00:01:54,150
+compound وين في ال heme؟ في تصنيع ال hemoglobin
+
+20
+00:01:55,660 --> 00:02:01,760
+واللي موجلبن carrying compound فبنلاقي فيه ايرون
+
+21
+00:02:01,760 --> 00:02:06,420
+للميوجلبن اصلا oxygen carrying compound برضه
+
+22
+00:02:06,420 --> 00:02:10,440
+مولودة في ال muscles ثم في certain انزايم زي
+
+23
+00:02:10,440 --> 00:02:14,520
+الستاكرومز وهي برعنة air electron transport enzyme
+
+24
+00:02:14,520 --> 00:02:20,040
+for oxidation المكان
+
+25
+00:02:20,040 --> 00:02:22,600
+التاني اللي موجود في ال cellular اللي هو نانهيم
+
+26
+00:02:23,060 --> 00:02:27,100
+ووجدوه في certain enzymes زي الـ NADPH أو الـ NADH
+
+27
+00:02:27,100 --> 00:02:30,720
+enzyme و الـ succinic dehydrogenase enzyme والتاني
+
+28
+00:02:30,720 --> 00:02:36,220
+المهمين في عمليات اللي هو سواء كانت ال iron
+
+29
+00:02:36,220 --> 00:02:41,820
+metabolism أو ال heme synthesis موقع تاني اللي
+
+30
+00:02:41,820 --> 00:02:46,240
+بنلاحظ في وجود ال iron هو ال compound which is
+
+31
+00:02:46,240 --> 00:02:51,320
+required which are required for iron storage و
+
+32
+00:02:53,680 --> 00:02:57,020
+يعني اللخصوها في تلت عوامل هي الـ Transferrin و ال
+
+33
+00:02:57,020 --> 00:03:03,340
+Hemocydrine و الفرّتين ما هو مخزون ال Iron في
+
+34
+00:03:03,340 --> 00:03:06,820
+الجسم قالوا ال Iron بيتكوّن في الجسم من أربعة جرام
+
+35
+00:03:06,820 --> 00:03:12,740
+في أربعة جرام Iron في الجسم تلت ترباعها موجودة as
+
+36
+00:03:12,740 --> 00:03:16,640
+Oxygen Carrying Compound Oxygen Carrying Compound
+
+37
+00:03:16,640 --> 00:03:21,370
+سواء كانت Hemoglobin أو Myoglobinيعني في ال blood
+
+38
+00:03:21,370 --> 00:03:28,390
+circulation أو في .. في ال muscle الربع الباقي هو
+
+39
+00:03:28,390 --> 00:03:32,550
+عبارة عن iron stores عبارة عن ايش؟ iron stores
+
+40
+00:03:32,550 --> 00:03:37,790
+وقسموها بالشكل هذا هي circulating هموجلبن 60% body
+
+41
+00:03:37,790 --> 00:03:44,130
+stores 25% ال circulating hemoglobin والميoglobin
+
+42
+00:03:44,130 --> 00:03:50,070
+10% 60% و7% و10% و70%تقريبا تلات ترباع والربع
+
+43
+00:03:50,070 --> 00:03:54,950
+الباقي هو ال 25 body stores ده ال 5% وجدوا 4% منها
+
+44
+00:03:54,950 --> 00:03:58,490
+في ال bone marrow واحد في المية enzyme وأقل من
+
+45
+00:03:58,490 --> 00:04:01,570
+point one موجود في البلازمة يعني circulating
+
+46
+00:04:01,570 --> 00:04:09,270
+البلازمة هيهم برضه مصنفة في جدوة أخر ال hemoglobin
+
+47
+00:04:09,270 --> 00:04:15,170
+حوالي 2500 milligram طبعا هذا ال male و هذا ال
+
+48
+00:04:15,170 --> 00:04:18,910
+female بتكون تعرفواإنه في فرق ما بين ال male و ال
+
+49
+00:04:18,910 --> 00:04:22,770
+female concentration
+
+50
+00:04:22,770 --> 00:04:28,730
+و طبعا ال male أكتر من ال female في
+
+51
+00:04:28,730 --> 00:04:33,120
+الهيموجلوبين في ال male حوالي 2500 ميلي جرام وهذا
+
+52
+00:04:33,120 --> 00:04:36,160
+بيه طبعا لأنه الهيموجلوبين في ال male أكتر من ال
+
+53
+00:04:36,160 --> 00:04:42,580
+female ال female 1700 ميجلوبين 500 برضه المصل أكتر
+
+54
+00:04:42,580 --> 00:04:48,500
+عند ال male في ال female 300 سيرام ايران 3 ميلي
+
+55
+00:04:48,500 --> 00:04:53,480
+جرام و ال iron stores من 500 لأقل عند ال male بما
+
+56
+00:04:53,480 --> 00:05:00,380
+لا يتجاوز ال 200 عند ال femaleالـ turnover of iron
+
+57
+00:05:00,380 --> 00:05:05,480
+بيتمثل بهذا ال figure ال iron وجدوا ان هو برعن one
+
+58
+00:05:05,480 --> 00:05:11,640
+way element بسله absorption و ب .. نمطس ال iron بس
+
+59
+00:05:11,640 --> 00:05:15,640
+بكمية قليلة من واحد لاتنين milligram daily و في
+
+60
+00:05:15,640 --> 00:05:21,200
+نفس الوقت نفقدهم عن طريق العرق ماشيطيب ها إيش
+
+61
+00:05:21,200 --> 00:05:27,060
+الحلقة هذه اللي بتدور فيها ال iron لأنه ال iron هو
+
+62
+00:05:27,060 --> 00:05:30,860
+عبارة عن مركب أساسي مكون أساسي لل hemoglobin و ال
+
+63
+00:05:30,860 --> 00:05:34,300
+hemoglobin موجودة في ال RBCs و بما أنه في عنا RBCs
+
+64
+00:05:34,300 --> 00:05:41,820
+كل يوم بتموت بكمية كبيرة و بيتصنع بدالها أيضا RBCs
+
+65
+00:05:41,820 --> 00:05:43,900
+بنفس الكمية لإنه في hemostasis
+
+66
+00:05:48,770 --> 00:05:53,190
+بتطلع من ال RBCs أيضًا بياخدها ال bone marrow مرة
+
+67
+00:05:53,190 --> 00:05:57,070
+تانية و بيصنع أن فيها RBCs فبالتالي فيه hemostasis
+
+68
+00:05:57,070 --> 00:06:06,090
+في ال iron turnover بالنسبالي ال myoglobin اللي
+
+69
+00:06:06,090 --> 00:06:08,570
+فيه 300 ميلي جرام و ال body store
+
+70
+00:06:12,290 --> 00:06:15,410
+هذه عوامل ثابتة اي يوم يكون الـ iron in excess
+
+71
+00:06:15,410 --> 00:06:19,590
+بصير عملية تخزين للـ iron في هذا المولود يبقى في
+
+72
+00:06:19,590 --> 00:06:23,470
+عندنا 10 over ثابت في عندنا hemostatic 10 over لل
+
+73
+00:06:23,470 --> 00:06:24,710
+iron كمية
+
+74
+00:06:28,830 --> 00:06:32,770
+ياخدوا البولمار و بيصنع فيه herbicides جديدة
+
+75
+00:06:32,770 --> 00:06:37,410
+وبالتالي بنفس الكمية وبالتالي مافقدش حاجة طبعا أيش
+
+76
+00:06:37,410 --> 00:06:41,270
+اللي بيطلع لو مافيش حاجة بتطلع فقط اللي بنفقده او
+
+77
+00:06:41,270 --> 00:06:45,730
+بيطلع منه هو عن طريق العرق و عن طريق ال urine و
+
+78
+00:06:45,730 --> 00:06:49,150
+الفيسيذ بيطلع شوية أيش اللي هو الكمية اللي احنا
+
+79
+00:06:49,150 --> 00:06:57,430
+بناخدها من الأكل WHO أيضا عملتاللي هو جدول بيبين
+
+80
+00:06:57,430 --> 00:07:01,690
+لي daily iron losses and requirement and في عمار
+
+81
+00:07:01,690 --> 00:07:08,750
+مختلفة وزي ما انتوا شايفين في انها daily loss في
+
+82
+00:07:08,750 --> 00:07:12,710
+ال urine و ال skin و ال feces و etc نفقدها فقطان
+
+83
+00:07:12,710 --> 00:07:17,930
+ماشي طبعا في ال female كمان في menses برضه تفقد
+
+84
+00:07:17,930 --> 00:07:26,270
+لكن بعد إيش بعد سن معين مجموع ما يفقدزائد مجموع ما
+
+85
+00:07:26,270 --> 00:07:34,570
+يحتاج الجسم يسمى الـ Total Iron Loss
+
+86
+00:07:37,240 --> 00:07:40,840
+و ال total iron loss المفروض ان هو total iron
+
+87
+00:07:40,840 --> 00:07:44,340
+requirement sorry وبالتالي هي هذه الجمهية المطلوبة
+
+88
+00:07:44,340 --> 00:07:50,080
+لإيش لكل إنسان في مرحلة من المرحل فعلى سبيل المثال
+
+89
+00:07:50,080 --> 00:07:55,160
+لو تاخدنا female عمرها 15 ل 17 سنة او 18 سنة في
+
+90
+00:07:55,160 --> 00:08:02,980
+المفروض تفقد تقريبا point 87 milligram
+
+91
+00:08:04,310 --> 00:08:07,770
+و في الmenses كمان تفقد حوالي point four في eight
+
+92
+00:08:07,770 --> 00:08:13,690
+لكنها في هذه السن لا تحتاج إلى نمو تفقدش اشي في
+
+93
+00:08:13,690 --> 00:08:17,390
+النمو فبالتالي الكمية اللى بتفقدها في هذا السن one
+
+94
+00:08:17,390 --> 00:08:20,630
+point three او بتحتاجها في هذا السن one point
+
+95
+00:08:20,630 --> 00:08:21,270
+three five
+
+96
+00:08:24,630 --> 00:08:27,430
+التالي Iron requirement زي ما اتفقنا هو عبارة عن
+
+97
+00:08:27,430 --> 00:08:30,590
+one way element يعني في absorption مافي execution
+
+98
+00:08:30,590 --> 00:08:34,710
+وبالتالي لابد من .. عشان نتحكم في هذا الموضوع لابد
+
+99
+00:08:34,710 --> 00:08:39,430
+من التحكم في ال absorption absorption is increased
+
+100
+00:08:39,430 --> 00:08:42,910
+in iron deficiency طبيعي يوم يقل ال iron بد الواحد
+
+101
+00:08:42,910 --> 00:08:47,130
+يمتص كمية أكبر and increase when body iron stores
+
+102
+00:08:47,130 --> 00:08:52,250
+are deleted برضه يوم تفضل مخازن بدنا ناخد air ناخد
+
+103
+00:08:52,250 --> 00:08:57,000
+iron أكتروبالتالي في قاعدة بتقول daily iron
+
+104
+00:08:57,000 --> 00:08:59,720
+requirement بتساوي ال amount lost زي ما شوفنا توفي
+
+105
+00:08:59,720 --> 00:09:04,920
+الجدول زي ال amount required طيب وقتاش بزيد الحاجة
+
+106
+00:09:04,920 --> 00:09:10,320
+لل iron يعني لو في ال female بيصير في menstruating
+
+107
+00:09:10,320 --> 00:09:13,880
+menstrual cycle شهرية
+
+108
+00:09:20,100 --> 00:09:24,700
+كل cycle ووجدوا ان هذه الكمية فيها من 15 ل 30
+
+109
+00:09:24,700 --> 00:09:31,680
+milligram يعني في كل one mil of blood في نص mil من
+
+110
+00:09:31,680 --> 00:09:37,760
+ال iron ايضا تفقد او تحتاج iron بكمية كبيرة
+
+111
+00:09:40,260 --> 00:09:44,940
+pregnancy يعني في fetus وبالتالي في fetal
+
+112
+00:09:44,940 --> 00:09:49,280
+placental growth وبالتالي في expansion لل blood
+
+113
+00:09:49,280 --> 00:09:54,680
+volume mother blood volume طبيعي الدورة الدموية
+
+114
+00:09:54,680 --> 00:10:00,280
+بتتضاعف ثم في نقطة مهمة جدا أو حرجة جدا وهي ال
+
+115
+00:10:00,280 --> 00:10:04,580
+hemorrhage in delivery كل female برضه تفقد كمية من
+
+116
+00:10:04,580 --> 00:10:11,220
+ال blood أثناء ولادها ال absorptionقالوا احنا
+
+117
+00:10:11,220 --> 00:10:15,840
+بنمتص حوالي خمسة لعشرة في المية من الحديد اللي
+
+118
+00:10:15,840 --> 00:10:19,440
+موجود في أكلنا جدش موجود حديد في أكلنا جاله من عشر
+
+119
+00:10:19,440 --> 00:10:24,700
+لخمستاشر ميلي جرام في اليوم طبعا ال .. ال ..
+
+120
+00:10:24,700 --> 00:10:29,000
+الحديد هذا موجود في أكلنا في ال .. في ال liver
+
+121
+00:10:29,000 --> 00:10:32,080
+يعني في الكبدة في ال red meat في ال green
+
+122
+00:10:32,080 --> 00:10:37,490
+vegetables ماعناش and supplemented cerealكل الحجوب
+
+123
+00:10:37,490 --> 00:10:44,430
+الـ fortified يعني اللي .. اللي مزودة
+
+124
+00:10:44,430 --> 00:10:51,730
+بالحديد and .. and fish ال dietary iron fall into
+
+125
+00:10:51,730 --> 00:10:56,550
+one of two category يا إما organic iron يا إما
+
+126
+00:10:56,550 --> 00:11:01,840
+inorganic iron طبعا ال inorganic iron هوأفضل
+
+127
+00:11:01,840 --> 00:11:05,240
+والميكانيزم تبعه معروف موجود في ال cereal و ال
+
+128
+00:11:05,240 --> 00:11:08,480
+vegetable و ال heme iron النوع التاني موجود في ال
+
+129
+00:11:08,480 --> 00:11:13,600
+.. في ال dairy و ال meat product كما تم عملية ال
+
+130
+00:11:13,600 --> 00:11:17,120
+absorption كانوا عملية ال absorption لل inorganic
+
+131
+00:11:17,120 --> 00:11:19,260
+usually
+
+132
+00:11:23,060 --> 00:11:27,160
+بتحسن في وجود reducing agent واش بيعمل ال reducing
+
+133
+00:11:27,160 --> 00:11:29,860
+agent؟ جاله reducing agent بزود ال solubility
+
+134
+00:11:29,860 --> 00:11:36,880
+وبالتالي بتكون complexes مع ال iron with this
+
+135
+00:11:36,880 --> 00:11:40,780
+reducing agent وبتم امتصاصها بسهولة أشهر ال
+
+136
+00:11:40,780 --> 00:11:44,620
+reducing agent هو ال ascorbic acid و الفيتا
+
+137
+00:11:44,620 --> 00:11:51,520
+والفروكتوز أيضا في glucose و succinate كلها عبارة
+
+138
+00:11:51,520 --> 00:11:52,100
+عناشر
+
+139
+00:11:55,260 --> 00:12:00,580
+الـ Reducing agent على عكس ذلك يمنع امتصاص الـ
+
+140
+00:12:00,580 --> 00:12:03,340
+Iron في وجود الـ Chelating agent أو الـ Chelating
+
+141
+00:12:03,340 --> 00:12:07,960
+agent ماذا تفعل هذه؟ تجعلها تكوّن Complexes يعني
+
+142
+00:12:07,960 --> 00:12:13,280
+يصعب امتصاصها يصعب امتصاصها زي ايش؟ زي وجود
+
+143
+00:12:13,280 --> 00:12:19,860
+الفوسفيت والفايتيت هذه عبارة عن موادالكالعين بتمنع
+
+144
+00:12:19,860 --> 00:12:24,100
+انتصاص الحديد طبعا موجودة زى ما انتوا شايفين كمان
+
+145
+00:12:24,100 --> 00:12:29,000
+فى التنيت اللى هو الشاي وشرب الشاي أثناء الأكل من
+
+146
+00:12:29,000 --> 00:12:34,980
+أسوأ العادات اللى نتبعها و اللى بتقلل من انتصاص
+
+147
+00:12:34,980 --> 00:12:41,540
+الحديد ال mechanism of iron absorption بتتم بهذه
+
+148
+00:12:41,540 --> 00:12:45,460
+الطريقة ناخد الأكل يدخل على الماعدة فى الماعد طبعا
+
+149
+00:12:45,460 --> 00:12:51,880
+بدخل على شكل فرقفي المعدة بيقابل pH واطية low pH
+
+150
+00:12:51,880 --> 00:12:57,900
+وفي وجود كمان reducing agent تاني في وجود vitamin
+
+151
+00:12:57,900 --> 00:13:04,340
+C او ascorbic acid بيتحول
+
+152
+00:13:04,340 --> 00:13:11,900
+الفرق إلى فرس و ثم بعد ذلك بينزل على الأمحاء وفي
+
+153
+00:13:11,900 --> 00:13:16,860
+الأمحاء ال pH مش acidic alkaline فبتحوله مرة تانية
+
+154
+00:13:17,430 --> 00:13:22,050
+الـ alkaline بيأتش إلى فرق compound طبعا بعد ذلك
+
+155
+00:13:22,050 --> 00:13:27,870
+بيصل للامهاق وفي الامهاق بتم امتصاصه على شكل فرق
+
+156
+00:13:27,870 --> 00:13:31,510
+على شكل فرق و بخش ال intestinal mycosal cell as
+
+157
+00:13:31,510 --> 00:13:38,060
+فرق compoundطيب احنا اتفقنا على انه فيه one way
+
+158
+00:13:38,060 --> 00:13:41,240
+element فى عملية امتصاص ولكن فىش عملية execution
+
+159
+00:13:41,240 --> 00:13:45,140
+وبالتالي عشان نتحكم فى كمية ال iron اللى بتخش
+
+160
+00:13:45,140 --> 00:13:51,620
+الجسم لابد من ايهاش من التحكم في ال absorption احد
+
+161
+00:13:51,620 --> 00:13:55,760
+النظريات اللى وضعت للتحكم في ال absorption نظرية
+
+162
+00:13:55,760 --> 00:13:58,760
+بيسموها mucosal block theory ايش بتقول النظرية
+
+163
+00:13:58,760 --> 00:14:03,040
+بتقول انه لما بيصل الحديد ل ال intestinal mucosa
+
+164
+00:14:03,040 --> 00:14:08,360
+بيتجمع فى ال intestinal mucosaثم بيتحسس الجسم
+
+165
+00:14:08,360 --> 00:14:15,880
+مخازن الحديد إذا المخازن فاضية بيسمح لل iron اللي
+
+166
+00:14:15,880 --> 00:14:20,300
+دخل ال intestinal mycosis أن يخش عن الجسم وإذا
+
+167
+00:14:20,300 --> 00:14:26,320
+المخازن مليانة بيضل الحديد مخزن as fair routine
+
+168
+00:14:26,320 --> 00:14:31,860
+فيهو ال intestinal mycosis يعني إيش؟ يعني هي عبارة
+
+169
+00:14:31,860 --> 00:14:37,560
+عن مبطأ .. بيثيلها ال cells في داخل الأمعاء بيثلها
+
+170
+00:14:37,560 --> 00:14:42,300
+sloughing out بعد يومين تلاتة كل يومين تلاتة
+
+171
+00:14:42,300 --> 00:14:49,320
+بتتجدد فبالتالي بتنزل مع ال .. مع ال stool أول بول
+
+172
+00:14:49,320 --> 00:14:56,280
+فإذا دلت مخزنة الحديدبينزل مع الاسطول إذا كان
+
+173
+00:14:56,280 --> 00:15:01,360
+المخازن فاضية يدخل على الجسم وبتم عملية انتصار
+
+174
+00:15:01,360 --> 00:15:09,420
+بيسموا هذه النظرية Myocosal Block Theory طيب
+
+175
+00:15:09,420 --> 00:15:13,300
+كيف ينقل الجسم واصل إلى هذه المرحلة؟ جاله ناقل ال
+
+176
+00:15:13,300 --> 00:15:17,300
+iron في الجسم هو عبارة عن بروتين اسمه Transferrin
+
+177
+00:15:17,300 --> 00:15:20,640
+وهو عبارة عن Beta Globulin واللي في العمليات تبعه
+
+178
+00:15:20,640 --> 00:15:21,460
+74000
+
+179
+00:15:30,370 --> 00:15:35,090
+بأكد الترانسفرين بيحمل الحديد على شكل فرّك
+
+180
+00:15:35,090 --> 00:15:41,470
+والايرون بعد ذلك is transported by ترانسفرين اللي
+
+181
+00:15:41,470 --> 00:15:47,910
+حامل الايرون إلى ال bone marrow بماكن تصنيع ال
+
+182
+00:15:47,910 --> 00:15:48,650
+hemoglobin
+
+183
+00:15:51,710 --> 00:15:59,250
+و هناك في خلايا الارتروبلاست على سطح ريسبتور
+
+184
+00:15:59,250 --> 00:16:05,510
+لترانسفيرن ريسبتور هذا الترانسفيرن ريسبتور بيمسك
+
+185
+00:16:05,510 --> 00:16:11,530
+بالترانسفيرن وبعدين بصير ترانسفيرن لترانسفيرن
+
+186
+00:16:12,180 --> 00:16:17,500
+رسيبتور بالـ Transferrin اللي حامل الحديد إلى داخل
+
+187
+00:16:17,500 --> 00:16:22,600
+الارتروبلاست ثم في داخل الارتروبلاست بيصير في
+
+188
+00:16:22,600 --> 00:16:28,600
+عملية removal لل iron اللي بيستغل في تصنيع الهيم
+
+189
+00:16:28,600 --> 00:16:32,520
+وبعد هيك بيصير exvagination برجع تاني الرسيبتور
+
+190
+00:16:32,520 --> 00:16:37,300
+على سطح الخلية متحمل محمول بالـ Transferrin لكن
+
+191
+00:16:37,300 --> 00:16:41,840
+المرة هذه Transferrin فاضيمحمول بترانسفرن
+
+192
+00:16:41,840 --> 00:16:44,820
+والترانسفرن في هذه الحالة أخد منه ال iron يعني
+
+193
+00:16:44,820 --> 00:16:50,500
+فاضي يسموه ابو ترانسفرن يبقى الترانسفرن الفاضي هو
+
+194
+00:16:50,500 --> 00:16:56,010
+ابو ترانسفرن المليان هو ترانسفرنطيب وصل ال
+
+195
+00:16:56,010 --> 00:16:58,530
+intestinal mycosis قلناها لو كانوا محتاجينه و
+
+196
+00:16:58,530 --> 00:17:03,150
+بنخششه على الجسم فبخش على الجسم على ال blood طبعا
+
+197
+00:17:03,150 --> 00:17:07,130
+في ال intestinal mycosis بيتحول مرة تانية لفرس و
+
+198
+00:17:07,130 --> 00:17:12,170
+بيخش على ال blood as ferrous و في ال blood في نظام
+
+199
+00:17:12,170 --> 00:17:17,610
+اسمه ferro oxidase بيحاولوا مرة تانية لفرق و as
+
+200
+00:17:17,610 --> 00:17:23,330
+ferric ال transferrin بيحمله as air as ferricيبقى
+
+201
+00:17:23,330 --> 00:17:30,610
+العملية صار فيها عملية تحويل لل iron من فرق لفرس
+
+202
+00:17:30,610 --> 00:17:37,810
+لفرق لفرس ثم بيحمل as فرق بيسمو هذه العملية double
+
+203
+00:17:37,810 --> 00:17:43,630
+redox reaction double redox يعني reduction
+
+204
+00:17:43,630 --> 00:17:51,150
+oxidation reaction طيب أشكل الحديد
+
+205
+00:17:52,130 --> 00:17:56,410
+أو مخزون الحديد قالوا فيه إنها شكلين أساسين
+
+206
+00:17:56,410 --> 00:18:02,710
+الأولاني بيسموه فرتين و هو الأساس ماشي و الفرتين
+
+207
+00:18:02,710 --> 00:18:06,770
+هو عبارة عن compound مولد للوية تبعه خمسة و اربعين
+
+208
+00:18:06,770 --> 00:18:10,810
+ألف بيتكوم من أربع و عشرين polypeptide subunits
+
+209
+00:18:10,810 --> 00:18:14,230
+مشكلة
+
+210
+00:18:14,230 --> 00:18:20,990
+على شكل halosphere يعني كرة ال diameter تبعها خمسة
+
+211
+00:18:20,990 --> 00:18:33,710
+نانومترلو فحصناها بنلاقي 25% منها Iron وزنا ووجدوا
+
+212
+00:18:33,710 --> 00:18:40,910
+أن مخزون الحديد اللي في الجسم بطولتينه عبارة عن
+
+213
+00:18:40,910 --> 00:18:45,070
+فراتين طولتينه عبارة عن إيش؟ عبارة عن فراتين يبقى
+
+214
+00:18:45,070 --> 00:18:51,390
+مخزون الحديد طولتينه على شكل فراتين و الفراتين هو
+
+215
+00:18:51,390 --> 00:18:52,130
+عبارة عن كل
+
+216
+00:18:56,170 --> 00:19:01,950
+العضلات تتجمع على شكل سفير يعني كرة ال diameter
+
+217
+00:19:01,950 --> 00:19:08,190
+تبعها خمسة نانومتر و ال iron موجود في مركزها مركز
+
+218
+00:19:08,190 --> 00:19:16,310
+هذه الكرة مركز هذه الكرة طبعا إذا كان capacity of
+
+219
+00:19:16,310 --> 00:19:21,790
+storage of iron infinity is exceeded اذا زادت
+
+220
+00:19:24,440 --> 00:19:28,900
+ببدأ يرتبط الفراتين بقضاء كمباوض زي الفوسفيت عند
+
+221
+00:19:28,900 --> 00:19:33,600
+هيدروكسايد فورم و ببدأ يتفتفت على شكل هيموسيبرين
+
+222
+00:19:33,600 --> 00:19:41,480
+اللي برضه موجود أي شكل الفراتين كرة في داخلها ال
+
+223
+00:19:41,480 --> 00:19:41,900
+iron
+
+224
+00:19:45,570 --> 00:19:50,070
+هو الـ Hemocydrine هو عبارة عن الـ amorphous form
+
+225
+00:19:50,070 --> 00:19:55,090
+of الريتين 37
+
+226
+00:19:55,090 --> 00:20:02,830
+% من وزن الحديد طبعا بشكل طول مخزون الحديد في
+
+227
+00:20:02,830 --> 00:20:07,770
+الجسم زيادته
+
+228
+00:20:07,770 --> 00:20:12,170
+خطيرة لأنه يترسب على أعضاء الجسم المختلفة ويمكن
+
+229
+00:20:12,170 --> 00:20:14,350
+يجعلها dysfunctional
+
+230
+00:20:16,080 --> 00:20:22,260
+طيب هذه علاقة رياضية من خلالها نستطيع نتعرف على
+
+231
+00:20:22,260 --> 00:20:26,940
+وجود ال iron في الجسم هل هو طبيعي ولا غير طبيعي؟
+
+232
+00:20:27,920 --> 00:20:31,740
+ماشي ايش هو ايش العلاقة هذه العلاقة بتقول ان ال
+
+233
+00:20:31,740 --> 00:20:35,840
+total iron binding capacity total iron قدرة ال
+
+234
+00:20:35,840 --> 00:20:39,260
+iron على الأرتباط بالtransfer يعني سموها total
+
+235
+00:20:39,260 --> 00:20:43,880
+iron binding capacity بساوي ال saturated يعني
+
+236
+00:20:43,880 --> 00:20:48,580
+المرتبط زائد ال unsaturated يعني غير مرتبط طبيعي
+
+237
+00:20:48,580 --> 00:20:55,200
+جدا ماشي وجدوا ان المرتبط فقط هو تلت كمية ال
+
+238
+00:20:55,200 --> 00:20:58,460
+transfer يعنيالـ Column هذا كله عبارة عن
+
+239
+00:20:58,460 --> 00:21:02,700
+Transferring تلتينه فاضي و التلت فقط هو اللي إيش
+
+240
+00:21:02,700 --> 00:21:06,320
+اللي شغال و التلت فقط هو اللي شغال هذا في الوضع
+
+241
+00:21:06,320 --> 00:21:10,920
+الطبيعي طبعا أي خلل في هذه العلاقة و هذه المعادلة
+
+242
+00:21:10,920 --> 00:21:15,600
+بيعني في حالة مرضية و من خلالها بنشخص حالات مرضية
+
+243
+00:21:15,600 --> 00:21:21,160
+مختلفة و هذا مثال حي على ذلك حي ال normal تلت
+
+244
+00:21:21,160 --> 00:21:30,870
+لومية مليان و الباقي200 فاضي لأن المجموع 300 مظبوط
+
+245
+00:21:30,870 --> 00:21:35,630
+فهذا هو الطبيعي ان التلت شغال و التلتين فاضي هذا
+
+246
+00:21:35,630 --> 00:21:39,370
+في الوضع الطبيعي يعني عندي transfer بزيادة انا
+
+247
+00:21:39,370 --> 00:21:45,190
+جاهز للارتباط بال .. بال iron لكن فقط اللي برتبط
+
+248
+00:21:45,190 --> 00:21:51,890
+هو ايش؟ هوتلت ال transferrin اللي موجود طبعا زي ما
+
+249
+00:21:51,890 --> 00:21:55,430
+قلتلكوا إذا كان المراقعة دي صار فيها خلل يصير فيه
+
+250
+00:21:55,430 --> 00:21:58,670
+إيش؟ أيه و في ال late pregnancy طبعا ال iron بيقل
+
+251
+00:21:58,670 --> 00:22:02,750
+كتير فال transferrin قدرتها على ارتباط بال iron
+
+252
+00:22:02,750 --> 00:22:07,610
+بيقل لكن بيزيد ال total iron binding capacity ماشي
+
+253
+00:22:07,610 --> 00:22:11,730
+ليش بيزيد؟ لأنه زاد ال volume وبالتالي هدا هي ها
+
+254
+00:22:11,730 --> 00:22:18,030
+هدا هي ال column زاد صار بدال 300 جديش؟ 500؟في الـ
+
+255
+00:22:18,030 --> 00:22:21,150
+iron deficiency نفس الحكاية جل ال iron كتير
+
+256
+00:22:21,150 --> 00:22:29,750
+وبالتالي يقلل ال transferrin binding capacity ال
+
+257
+00:22:29,750 --> 00:22:32,290
+.. ال .. ال transferrin اللي حامل الحديد يعني
+
+258
+00:22:32,290 --> 00:22:37,810
+saturation يعني لكن برضه في نفس الحكاية بيصير فيه
+
+259
+00:22:37,810 --> 00:22:41,830
+زيادة في total iron binding capacity في الثلاثيمية
+
+260
+00:22:41,830 --> 00:22:51,090
+ال iron بيزيادة ماشي لكن فشيبلد volume كتير ف
+
+261
+00:22:51,090 --> 00:22:54,710
+total aerobic capacity بتقل و هكذا يبقى من خلال
+
+262
+00:22:54,710 --> 00:23:00,430
+هذه المعادلة احنا بنستطيع ان نشخص حالات مرضية
+
+263
+00:23:00,430 --> 00:23:07,170
+مختلفة و هذا ال profile اللي من خلاله ممكن نعمله و
+
+264
+00:23:07,170 --> 00:23:10,430
+نشخص اللي هو different types of anemia هي ال
+
+265
+00:23:10,430 --> 00:23:14,920
+aerodeficiency chronic anemiaثلاثيميا و
+
+266
+00:23:14,920 --> 00:23:18,360
+Ancedroplastic Anemia كلها عبارة عن أنيميا بتتعلق
+
+267
+00:23:18,360 --> 00:23:24,460
+بالحديد و هي الفحوصات ICBC الـ Iron Total Iron
+
+268
+00:23:24,460 --> 00:23:28,060
+Bending Capacity Transferrin Saturation اللي هو
+
+269
+00:23:28,060 --> 00:23:33,820
+نسبة تشبع الترانسفيرن بالحديد ثم Serum Ferritin ثم
+
+270
+00:23:33,820 --> 00:23:37,760
+Serum Transferrin Receptor ثم ال Bonmarin Iron
+
+271
+00:23:37,760 --> 00:23:40,180
+Store و ال Erythroplast
+
+272
+00:23:43,910 --> 00:23:48,030
+سيرام الـ Transferrin Receptor ببساطة يا بنات و يا
+
+273
+00:23:48,030 --> 00:23:51,610
+شباب هو عبارة عن الـ Receptor اللي بيحمل الـ
+
+274
+00:23:51,610 --> 00:23:56,730
+Transferrin اللي ماسك الحديد طيب إذا كان .. احنا
+
+275
+00:23:56,730 --> 00:23:59,430
+بنقول سيرام، وين موجود هذا؟ موجود على الارثروبلاست
+
+276
+00:23:59,430 --> 00:24:02,750
+طب إيش دخل السيرام في الموضوع؟ قالوا اليوم يكون
+
+277
+00:24:02,750 --> 00:24:08,730
+الـ Iron قليل بيكون
+
+278
+00:24:08,730 --> 00:24:14,840
+الـ Transferrin هذا الـ Receptor لا يشغليكون
+
+279
+00:24:14,840 --> 00:24:18,240
+استخدامه قليل وإذا لم يستغل ال Transferring
+
+280
+00:24:18,240 --> 00:24:23,640
+Receptor يصبح له Truncation يخلع من الاربيز من ال
+
+281
+00:24:23,640 --> 00:24:28,000
+الاثرويد سيل ويصبح له إطلاق في البلازمة أو في
+
+282
+00:24:28,000 --> 00:24:32,800
+السيرام فيوم ما نشوفه عالي في السيرام أو البلازمة
+
+283
+00:24:32,800 --> 00:24:40,550
+ال Receptor بيكون فيه Iron Deficiencyأو بيكون فيه
+
+284
+00:24:40,550 --> 00:24:44,030
+Anemia أو Microdisorder، دلوقت هنحكي عليها لكن في
+
+285
+00:24:44,030 --> 00:24:50,230
+حالة وجود اللي هو النقص في الحديد برضو أو في مخزون
+
+286
+00:24:50,230 --> 00:24:56,210
+الحديد عشان هي كفي كثير من المعامل عملية التفريق
+
+287
+00:24:56,210 --> 00:24:59,670
+ما بين ال Anemia أرض في شنسي أنيميا و Anemia
+
+288
+00:24:59,670 --> 00:25:04,510
+Microdisorder بتتم من خلال هذا ال marker وهو Serum
+
+289
+00:25:04,510 --> 00:25:06,490
+Transferrin Receptor
+
+290
+00:25:09,800 --> 00:25:15,360
+و نبدأ الأن نشوف أمثلة على ال iron metabolism
+
+291
+00:25:15,360 --> 00:25:20,120
+disorder و زي ما قلتلكوا أشهر هذه الحالات هي iron
+
+292
+00:25:20,120 --> 00:25:27,160
+deficiency anemia بتم فيها نقص في ال iron
+
+293
+00:25:27,160 --> 00:25:34,700
+concentration أقل من الطبيعي و شوي شوي بزيد النقص
+
+294
+00:25:34,700 --> 00:25:35,800
+إلى أنص
+
+295
+00:25:43,690 --> 00:25:46,390
+Iron Deficiency Anemia وبالتالي Iron Deficiency
+
+296
+00:25:46,390 --> 00:25:51,670
+Anemia هي عبارة عن مراحل أخر مرحلة هي التي تظهر
+
+297
+00:25:51,670 --> 00:25:57,090
+فيها symptoms بغضوح و بيسموها Iron Deficiency
+
+298
+00:25:57,090 --> 00:26:01,710
+Anemia ما هي المراحل تاعة Iron Deficiency Anemia؟
+
+299
+00:26:01,710 --> 00:26:05,230
+يقولوا نمرا واحد Negative Iron Balance ماشي يعني
+
+300
+00:26:05,230 --> 00:26:09,750
+Negative Iron Balance؟ يعني والله كمية الحديده
+
+301
+00:26:09,750 --> 00:26:15,530
+التي تمتص من برا تتاخد من برافببدأ الإنسان ياخد
+
+302
+00:26:15,530 --> 00:26:20,330
+إياش من المخزون ببدأ الإنسان ياخد من إياش من
+
+303
+00:26:20,330 --> 00:26:24,990
+المخزون نمرة اتنين latent iron deficiency إذا
+
+304
+00:26:24,990 --> 00:26:30,230
+استمرت الحكاية زيادة عن اللزوم بتفضل مخازنه لكن
+
+305
+00:26:30,230 --> 00:26:35,130
+لازال فيه normal hemopoiesis كمية الحديد اللي
+
+306
+00:26:35,130 --> 00:26:42,810
+بتتاخد من المرة بتكفي لعمل لتصنيع خلايانمر تلاتة
+
+307
+00:26:42,810 --> 00:26:47,770
+إذا تطورت أكتر نصل لمرحلة بتفضل مخازن وما بتكفل
+
+308
+00:26:47,770 --> 00:26:53,250
+كمية اللي بتتاخد من برا فبالتالي بيشير في حالة
+
+309
+00:26:53,250 --> 00:26:56,410
+بيسموها iron deficient erythropoiesis خلل في
+
+310
+00:26:56,410 --> 00:27:01,310
+الاريثروبييسيس طبعا في مرحلة متقدمة جدا بعد ذلك
+
+311
+00:27:01,310 --> 00:27:04,790
+إذا استمرت بيشير في iron deficient cyanemia
+
+312
+00:27:04,790 --> 00:27:10,810
+وبالتالي البولمار بيكون يعني متأثر تأثرا كبيرا
+
+313
+00:27:13,040 --> 00:27:16,260
+أسباب الـ iron deficiency أنينيا كانوا يبروحها
+
+314
+00:27:16,260 --> 00:27:21,000
+decrease supply of iron يعني فاش ايران بيخش الجسم
+
+315
+00:27:21,000 --> 00:27:25,660
+or increase requirement of our iron يعني في زيادة
+
+316
+00:27:25,660 --> 00:27:30,480
+في الطلب عليه احتياجاتنا أكتر ونبدأ بأول سبب وهو
+
+317
+00:27:30,480 --> 00:27:34,600
+decrease supply of iron كانوا بتندرج عن تحتي
+
+318
+00:27:35,390 --> 00:27:40,030
+الأسباب الاتيانية إنها adequate diet بمعنى إنه
+
+319
+00:27:40,030 --> 00:27:44,070
+والله مافيش حديد في الأكل اللي بناخده وده كلام
+
+320
+00:27:44,070 --> 00:27:48,590
+بينطبقش على الأكل الشرقي لإنه في الأكل الشرقي في
+
+321
+00:27:48,590 --> 00:27:53,930
+حديد بكميات كبيرة توصل ل 18 milligram من ال iron
+
+322
+00:27:53,930 --> 00:28:00,210
+احنا فقط بناخد منها من خمسة لعشر أفلمية سبب تاني
+
+323
+00:28:00,210 --> 00:28:04,740
+which is common usuallyوهو مال absorption of
+
+324
+00:28:04,740 --> 00:28:09,900
+dietary iron مال absorption of dietary iron طيب،
+
+325
+00:28:09,900 --> 00:28:11,920
+شو اللي بيصير؟ قالوا اللي مافي خلل في absorption.
+
+326
+00:28:12,240 --> 00:28:15,680
+إيش الدعوة؟ قالوا في خلل في مواقع انتصاص الحديد.
+
+327
+00:28:16,080 --> 00:28:18,580
+طب وين بيمتص الحديد؟ قالوا في الأبر، elementary
+
+328
+00:28:18,580 --> 00:28:22,960
+tract, dodenal والأبرجيجنال، يكون في خلل في
+
+329
+00:28:22,960 --> 00:28:29,320
+الأمهات وبالتالي بيصير في خلل في الانتصاص.من أشهر
+
+330
+00:28:29,320 --> 00:28:32,880
+الأمراض اللي بتعمل هذا الخلل هو celiac disease عدم
+
+331
+00:28:32,880 --> 00:28:36,880
+امتصاد طبعا celiac disease اللي هو بيصير فيهاش عدم
+
+332
+00:28:36,880 --> 00:28:40,340
+امتصاد لكميات كبيرة من ال minerals و ال .. و ال
+
+333
+00:28:40,340 --> 00:28:45,940
+atoms السبب في ذلك انه مافيهاش في اللي هو أتروفي
+
+334
+00:28:45,940 --> 00:28:52,860
+للcelia شو اللي بيصير؟ بيصير عدم امتصاد طب في
+
+335
+00:28:52,860 --> 00:28:56,820
+حالات أخرى برضه بيصير فيه عدم امتصاد جاله نعميوم
+
+336
+00:28:56,820 --> 00:29:00,640
+يكون في partial gastrectomy واحد صار عنده خلل في
+
+337
+00:29:00,640 --> 00:29:05,480
+ال .. في ال .. في ال stomach و شلوله جزء منها
+
+338
+00:29:05,480 --> 00:29:12,040
+بيسموها gastrectomy partial gastrectomy او استخدام
+
+339
+00:29:12,040 --> 00:29:16,320
+ال antacid انجش الناس كتير تحصل معاهم حموضة فبياخد
+
+340
+00:29:16,320 --> 00:29:21,020
+كميات كبيرة من ال antacid هذي ايضا تمنع الانتصاص
+
+341
+00:29:21,020 --> 00:29:26,330
+الحديد لإن أوللقاء بين الحديد و بين .. في الجسم هو
+
+342
+00:29:26,330 --> 00:29:37,470
+ال stomach و ان ال acid medium is important السبب
+
+343
+00:29:37,470 --> 00:29:41,290
+التاني لل iron deficiency هو increase requirement
+
+344
+00:29:41,290 --> 00:29:47,390
+for iron و يتدرج تحته تلت أسباب أساسية هو ال blood
+
+345
+00:29:47,390 --> 00:29:53,890
+loss طبعا يوم يفقد الدم للإنسانثم growth and
+
+346
+00:29:53,890 --> 00:29:58,430
+pregnancy and loss of iron ونشوف وقت إيش بيصير فيه
+
+347
+00:29:58,430 --> 00:30:01,790
+blood loss لأنه من أشهر الأسباب اللي بيصير فيها
+
+348
+00:30:01,790 --> 00:30:05,750
+فقدر على الدم menstruation طبعا دورة شهرية
+
+349
+00:30:05,750 --> 00:30:13,210
+parasitic infection ناس بيكون عندهم infestation by
+
+350
+00:30:13,210 --> 00:30:19,230
+angostoma and nicator americanus هدول عبارة عن
+
+351
+00:30:27,850 --> 00:30:33,610
+Carcinoma Tudinal ulcer قرحة في الاثنين عشر
+
+352
+00:30:33,610 --> 00:30:42,550
+هيتاسيرمية اللي هو افتاج السرعة Homeroid و
+
+353
+00:30:42,550 --> 00:30:46,570
+Minorrhagia ال homeroid اللي هو البواصير و ال
+
+354
+00:30:46,570 --> 00:30:50,390
+minorrhagia اللي هي excessive menses
+
+355
+00:30:53,300 --> 00:30:55,780
+هذا أول سبب السبب التاني growth and pregnancy
+
+356
+00:30:55,780 --> 00:31:01,820
+تفقناه بشكل طبيعي أثناء البلوغ أثناء المراهقة طبعا
+
+357
+00:31:01,820 --> 00:31:06,880
+بستيد اللي هو فترة نمو الإنسان يحتاج لحديد أكتر
+
+358
+00:31:06,880 --> 00:31:14,510
+أيضا في حالات ال pregnancyففي ال pregnancy ال
+
+359
+00:31:14,510 --> 00:31:18,630
+female بتتعرض ل 3 challenges تلت تحديات مختلفة
+
+360
+00:31:18,630 --> 00:31:22,770
+التحدي الأولاني أنه بزيد حجم ال blood volume عندها
+
+361
+00:31:22,770 --> 00:31:28,470
+بحوالي 20 ل 40% وهذا بيترتب عليه زيادة في امتصاص
+
+362
+00:31:28,470 --> 00:31:35,710
+الحديد بنسبة 500 milligram نمرة
+
+363
+00:31:35,710 --> 00:31:37,150
+2 ده development fetus
+
+364
+00:31:42,650 --> 00:31:46,150
+يبقى احنا فقدنا في زيادة حجم الدم 500 مليغرام
+
+365
+00:31:46,150 --> 00:31:51,790
+فقدنا فيه الجنين أخد 300 وعند الولادة ال female
+
+366
+00:31:51,790 --> 00:31:59,070
+بتفقد حوالي 500 ملي من ال blood فيهم 250 ملي من
+
+367
+00:31:59,070 --> 00:32:03,600
+ملي جرام من ال ironفالمجموع بيطلع حوالي 1500 ..
+
+368
+00:32:03,600 --> 00:32:11,640
+1050 يعني جرام و خمسين ملي جرام من ال iron بيفقد
+
+369
+00:32:11,640 --> 00:32:14,660
+الشيء الوحيد الإيجابي في الموضوع أنه في ال
+
+370
+00:32:14,660 --> 00:32:18,520
+pregnancy مافيش من ال menstruation فده بتعوض
+
+371
+00:32:18,520 --> 00:32:23,400
+الفيميل بحوالي 200 ملي جرام من ال iron بس يعني في
+
+372
+00:32:23,400 --> 00:32:29,090
+جميع الأحوال اللي بيضل حوالي 850 ملي جرام فاقد850
+
+373
+00:32:29,090 --> 00:32:33,710
+ملي جرام يعني احنا تقريبا تلت مخزونة او تلت الحديد
+
+374
+00:32:33,710 --> 00:32:40,670
+اللي في جسمها كله بكلبرجنانسي بيستهلك loss of iron
+
+375
+00:32:40,670 --> 00:32:43,870
+اكثر من كثير ممكن يصير فيه عملية loss of iron
+
+376
+00:32:43,870 --> 00:32:49,150
+during intravascular hemolysis وطبعا كمية كبيرة من
+
+377
+00:32:49,150 --> 00:32:54,870
+ال iron as hemocedrine يفقد في الورينوطيب،
+
+378
+00:32:54,870 --> 00:32:57,750
+الانعكاسات هذه تأثيرها ال pathophysiology، الألية
+
+379
+00:32:57,750 --> 00:33:01,210
+المرضية، إيش اللي بنصير؟ قالوا والله ال iron
+
+380
+00:33:01,210 --> 00:33:06,590
+deficiency عينيميا غالبا بتكون مسحوبة ب clinical
+
+381
+00:33:06,590 --> 00:33:11,030
+manifestation، two clinical manifestation إيش؟ هم
+
+382
+00:33:11,030 --> 00:33:16,330
+قالوا يوم ما اتأثر على ال blood و ال blood forming
+
+383
+00:33:16,330 --> 00:33:21,750
+tissueو حاجة تانية بتأثر على ال other tissue و
+
+384
+00:33:21,750 --> 00:33:26,010
+هنشوف إيش تأثيراتها على كل من هنا تأثير الأولاني
+
+385
+00:33:26,010 --> 00:33:30,270
+على blood و blood forming tissue طبعا يوم يقل ال
+
+386
+00:33:30,270 --> 00:33:36,690
+iron يقل تصنيع ال hemoglobin ماشي و هذا يعني عكس
+
+387
+00:33:36,690 --> 00:33:43,490
+كالأياتي نمر واحد يقل ال hemoglobin و في الخلية
+
+388
+00:33:43,490 --> 00:33:48,810
+طبعا و هذا بنشوفه بوضوحيوم ما يكون الـ MCHC برضه
+
+389
+00:33:48,810 --> 00:33:56,490
+واطية بزيد الـ preprotoporphin تركيزه في الخلية
+
+390
+00:33:56,490 --> 00:34:02,490
+والـ protoporphin هو عبارة عن المادة التي تسبق أو
+
+391
+00:34:02,490 --> 00:34:09,010
+المركبة اللذي يسبق الهيم في تكوينه فبالتالي يوم ما
+
+392
+00:34:09,010 --> 00:34:14,270
+يكون مافيش حديد يبقى مافيش هيمSynthesis فشو بيضل
+
+393
+00:34:14,270 --> 00:34:22,730
+المركب اللي بيتراكم اللي هو ال Protoporphine لإنه
+
+394
+00:34:22,730 --> 00:34:28,610
+ما بيتحول إلى الهيم في تصنيع ال hemoglobin طبعا
+
+395
+00:34:28,610 --> 00:34:34,970
+شواء شوية ال RBCs بتصير microcytic hypochromic و
+
+396
+00:34:34,970 --> 00:34:38,190
+microcytosis لإنه بتقعد في ال bone marrow فترة
+
+397
+00:34:38,190 --> 00:34:43,700
+أكبر تستنىيعني حصولها على الـ Iron وبالتالي طول ما
+
+398
+00:34:43,700 --> 00:34:47,520
+هي جاعدة في البرمرو وطول ما هي بتنقسم الخلية
+
+399
+00:34:47,520 --> 00:34:52,540
+فبتصغر عشان هيك ال anemia of iron deficiency هي
+
+400
+00:34:52,540 --> 00:34:56,980
+عبارة عن microcytic hypochromic anemia بس يكون
+
+401
+00:34:56,980 --> 00:35:00,920
+فيها reticulocytopenia طبعا مافيش إنتاج للحديد
+
+402
+00:35:00,920 --> 00:35:05,480
+مافيش .. مافيش امتصاص للحديد مافيش إنتاج لل
+
+403
+00:35:05,480 --> 00:35:10,470
+hemoglobinالتي تسمى Erythropoiesis is defected
+
+404
+00:35:10,470 --> 00:35:17,730
+وبالتالي معامل إنتاج ال bone marrow يعني ال RBCs
+
+405
+00:35:17,730 --> 00:35:23,090
+بيتمثل بوجود ال reticulocyte لأنه قلنا بتنزل على
+
+406
+00:35:23,090 --> 00:35:26,010
+ال peripheral blood ال reticulocyte جاب اليوم من
+
+407
+00:35:26,010 --> 00:35:32,410
+تحولها إلى ال mature تقعد يوم فهي indicator وجودها
+
+408
+00:35:32,410 --> 00:35:34,910
+indicator في ال peripheral blood على إنه في إنتاج
+
+409
+00:35:34,910 --> 00:35:40,030
+لل bone marrow عشان هيك بيسموها معاملBone marrow
+
+410
+00:35:40,030 --> 00:35:43,950
+production index طيب لو مافيش reticulocyte مافيش
+
+411
+00:35:43,950 --> 00:35:47,910
+انتاج عشان هي كان في ال iron deficiency يعني ما
+
+412
+00:35:47,910 --> 00:35:54,770
+مافي انتاج فبالتالي في reticulocyte فيه الاشي
+
+413
+00:35:54,770 --> 00:36:00,730
+التاني اللي او الرابع اللي ممكن نشوفه انه نفحص ال
+
+414
+00:36:00,730 --> 00:36:02,990
+bone marrow و في ال bone marrow بنلاقي
+
+415
+00:36:06,360 --> 00:36:11,320
+هيبو بليجيا يعني مافي عملية تصنيع لل إيراثرويد
+
+416
+00:36:11,320 --> 00:36:18,400
+precursor cell هيبو قلة بليجيا تصنيع وتكوين ماشي
+
+417
+00:36:18,400 --> 00:36:25,660
+وبالتالي مافي كمان لو فحصنا ال iron في مخازن ال
+
+418
+00:36:25,660 --> 00:36:26,680
+bomber اللي هي ال macro
+
+419
+00:36:30,990 --> 00:36:37,130
+وبالتالي الـ cytoplasm تبع ال macrophage .. تبع ال
+
+420
+00:36:37,130 --> 00:36:41,050
+normoplast هو عبارة عن cytoplasm منقطة ragged يعني
+
+421
+00:36:41,050 --> 00:36:45,010
+منقطة ليش منقطة؟ قالوا نسبة النطفة اللي بيصير فيها
+
+422
+00:36:45,010 --> 00:36:50,590
+تصنيع hemoglobin تتلون و اللي ما بيصير ما بتتلون
+
+423
+00:36:50,590 --> 00:36:55,090
+فبالتالي بنلاقي cytoplasm جزء منه ملون و جزء منه
+
+424
+00:36:55,090 --> 00:36:57,230
+مش ملون عشان هيك بنلاقيه منقطة
+
+425
+00:37:00,060 --> 00:37:04,940
+يبجى عشان انا اعمل اللي هو اشخص Aerodeficiency
+
+426
+00:37:04,940 --> 00:37:09,280
+Anemia بدي اعمل القادي بعد دي اعمل CBC واشوف قلة
+
+427
+00:37:09,280 --> 00:37:14,360
+ال hemoglobin و ال blood index ثم بدي افحص ال
+
+428
+00:37:14,360 --> 00:37:19,180
+protocol ثم بدي اعمل blood film واشوف microcytic
+
+429
+00:37:19,180 --> 00:37:23,460
+hypochromic anemia ثم بدي اشوف ال reticulocytes
+
+430
+00:37:29,540 --> 00:37:32,880
+طب هذا بالنسبة لإيش لل hematological analyst طب و
+
+431
+00:37:32,880 --> 00:37:35,560
+بالنسبة لل chemistry قالوا ال chemistry بتعمل
+
+432
+00:37:35,560 --> 00:37:39,100
+biochemical reaction أو biochemical profile test
+
+433
+00:37:40,290 --> 00:37:45,370
+ماشي لمين لل iron فبتفحص ال iron و مخزون ال iron
+
+434
+00:37:45,370 --> 00:37:49,410
+اللي هو الفرتين و ال total iron binding capacity و
+
+435
+00:37:49,410 --> 00:37:53,770
+ال percent of saturation لل transferrin و بتشوف ال
+
+436
+00:37:53,770 --> 00:37:59,570
+serum transferrin receptors كل هذه عوامل ممكن
+
+437
+00:37:59,570 --> 00:38:01,690
+تفحصها و تشوفها
+
+438
+00:38:04,220 --> 00:38:09,420
+ال figure هذا مبين ليه اللي هو التطور اللي بتمر في
+
+439
+00:38:09,420 --> 00:38:14,660
+خلية ال RBCs في وجود iron deficiency بتبدأ ب
+
+440
+00:38:14,660 --> 00:38:21,080
+normal و بتنتهي ب microcytic hypochromic anemia و
+
+441
+00:38:21,080 --> 00:38:24,240
+هذا عبارة عن profile ممكن نعمله في حالة ال iron
+
+442
+00:38:24,240 --> 00:38:29,200
+deficiency أنيميا وهي اللي نتعيش طيب هذا بالنسبة
+
+443
+00:38:29,200 --> 00:38:32,080
+لتأثيره على ال blood blood forming unit طب تأثيره
+
+444
+00:38:32,080 --> 00:38:32,520
+على other
+
+445
+00:38:36,080 --> 00:38:40,020
+التيشو ياله بيأثر على ال rapidly dividing cell
+
+446
+00:38:40,020 --> 00:38:43,120
+اللى هى ال epithelial cells اللى دايما بتتجدد
+
+447
+00:38:43,120 --> 00:38:48,920
+فبيأثر على بيعمل coelynesia ودى عبارة عن spoon
+
+448
+00:38:48,920 --> 00:38:56,020
+nail of the finger ماشى يعني ايه القدفر بياخد شكل
+
+449
+00:38:56,020 --> 00:38:57,900
+يتقهر
+
+450
+00:39:00,830 --> 00:39:05,030
+بسموها coil anesia ثم angular stomatitis بتلاقي
+
+451
+00:39:05,030 --> 00:39:12,950
+طرفي الفم صار فيهم atrophy ثم aglossitis بتلاقي
+
+452
+00:39:12,950 --> 00:39:18,570
+الإجسام صار فيه smooth and flamed tongue ثم
+
+453
+00:39:18,570 --> 00:39:22,990
+atrophic gastritis بيصير فيه inflammation of the
+
+454
+00:39:22,990 --> 00:39:29,670
+lining of the stomach ثم achlorohydra يعني مافيش
+
+455
+00:39:30,670 --> 00:39:35,590
+Hydrochloric acid في ال .. في ال stomach ثم Pika
+
+456
+00:39:35,590 --> 00:39:39,130
+Pika هي عبارة عن غاهرة لجوا ان الناس اللي عندهم
+
+457
+00:39:39,130 --> 00:39:43,710
+iron deficiency عندهم تصرفات غريبة انهم ممكن
+
+458
+00:39:43,710 --> 00:39:51,610
+ياكلوااللي هو المواد المثلجة اللي هي ال ice زي ال
+
+459
+00:39:51,610 --> 00:39:54,850
+.. ال .. ال .. ال .. بيسموها pediophagia أو ال
+
+460
+00:39:54,850 --> 00:39:58,750
+soil geophagia ممكن ياكلوا عاجزة غريبة زي الصوفي
+
+461
+00:39:58,750 --> 00:40:05,210
+ناتشو زي الرمل ينبلع و هكذا هذه ال coil anemia
+
+462
+00:40:05,210 --> 00:40:09,850
+المرض
+
+463
+00:40:09,850 --> 00:40:12,550
+التاني اللي بتعلق بال iron هو ال anemia و ال
+
+464
+00:40:12,550 --> 00:40:16,360
+chronic disordersوالانيميا و ال chronic disorders
+
+465
+00:40:16,360 --> 00:40:23,160
+من الإسم أنيميا ناتجة عن chronic disease يعني إذا
+
+466
+00:40:23,160 --> 00:40:28,120
+كان chronic inflammation أو ماليجنانسي و عادة
+
+467
+00:40:28,120 --> 00:40:31,220
+usually هي normocytic و normochronic لكن بتصير
+
+468
+00:40:31,220 --> 00:40:36,400
+برضه hypocytic .. hypochromic microcytic
+
+469
+00:40:36,400 --> 00:40:43,350
+hypochromic sorryand طبعا هذه لا يشفى الإنسان منها
+
+470
+00:40:43,350 --> 00:40:48,470
+إلا بشفاء السبب الأساسي ال primary cause قلية
+
+471
+00:40:48,470 --> 00:40:53,530
+المرض pathophysiology يعني هو بيصير في القاهة نمر
+
+472
+00:40:53,530 --> 00:40:56,570
+واحد في chronic inflammation ال inflammatory
+
+473
+00:40:56,570 --> 00:41:05,020
+process usually بتكون مصحوبة بميكانزمات منعيةفأول
+
+474
+00:41:05,020 --> 00:41:08,760
+هذه الأشياء أو الخلايا المنعية المتأثرة في هذا
+
+475
+00:41:08,760 --> 00:41:12,300
+الموضوع ال macro phage قالوا يوم السويس كون فيه
+
+476
+00:41:12,300 --> 00:41:17,820
+chronic inflammation ال macro phage بتزود ال
+
+477
+00:41:17,820 --> 00:41:22,220
+abutransfer receptor على سطحها شو بده يعمل هذا ال
+
+478
+00:41:22,220 --> 00:41:26,540
+receptor بيروحوا ملجة ال transferrin وإذا كان قل
+
+479
+00:41:26,540 --> 00:41:29,640
+ال transferrin بده يقل ال total iron binding
+
+480
+00:41:29,640 --> 00:41:34,210
+capacityالحاجة التانية كمان في ال inflammation
+
+481
+00:41:34,210 --> 00:41:38,190
+تتنشط ال neutrophil وتروح يصنع كميات كبيرة من
+
+482
+00:41:38,190 --> 00:41:44,590
+الابولاكتوفرين و بتفرزها والابولاكتوفرين اللي هو
+
+483
+00:41:44,590 --> 00:41:48,230
+ال receptor على سطح الماكروفيج فبروح و جاعد على
+
+484
+00:41:48,230 --> 00:41:52,330
+الابولاكتو .. على سطح الماكروفيج و الماكروفيج وهي
+
+485
+00:41:52,330 --> 00:41:56,030
+ماشية .. شو بتعمل بالابولاكتوفرين؟ الاكتروفين ده
+
+486
+00:41:56,030 --> 00:41:59,170
+وظيفته الأساسية عملية طلقية ال iron برتبط بال iron
+
+487
+00:42:00,630 --> 00:42:05,110
+فبروحوا ملقّة الـ iron وكأنه مغناطيس ملقّة ال iron
+
+488
+00:42:05,110 --> 00:42:10,990
+الموجود فيه ال blood فصار ال iron مرتبط بالـ
+
+489
+00:42:10,990 --> 00:42:14,090
+receptor على سطح ال macro phage ثم بيصله
+
+490
+00:42:14,090 --> 00:42:18,370
+internalization بيخزن في داخل ال macro phage as
+
+491
+00:42:18,370 --> 00:42:25,510
+فرتين فالفرتين بيزيد يبقى ال iron قلوالفراتين زاد
+
+492
+00:42:25,510 --> 00:42:30,390
+و ال ايرو نقاش قل و الفراتين زاد و الدعم اول
+
+493
+00:42:30,390 --> 00:42:35,770
+اعرفنا ان ال total aerobatic capacity قلت طب مش
+
+494
+00:42:35,770 --> 00:42:39,550
+فيه كمان بيشير قالوا الارتروبيوتك activity is
+
+495
+00:42:39,550 --> 00:42:46,050
+suppressed يعني بكل الإمتاز مش طب ليش؟Cytokine
+
+496
+00:42:46,050 --> 00:42:49,930
+release يوم ما تتنشط هذه الخلايا المناعية بتفرز IL
+
+497
+00:42:49,930 --> 00:42:54,230
+-1 وبتفرز Gamma Interferon وTumor Necrosis Factor
+
+498
+00:42:54,230 --> 00:42:58,550
+وهذه عبارة عن Inhibitory Cytokine شو بتعمل؟ بتعمل
+
+499
+00:42:58,550 --> 00:43:02,790
+Inhibition لل Erythropoiesis طب وإيش بالتالي؟
+
+500
+00:43:02,790 --> 00:43:06,750
+بالتالي بيقلل ال Erythropoietic Activity طيب هي
+
+501
+00:43:06,750 --> 00:43:10,590
+قلت ال Erythropoietic Activity قالوا كمان بتقل ال
+
+502
+00:43:10,590 --> 00:43:14,940
+life span تبع ال herpesيعني كله بيقل و بتتاري
+
+503
+00:43:14,940 --> 00:43:20,260
+المحصة لأنيميا طب كيف بنشخص؟ قالوا الانيميا هي
+
+504
+00:43:20,260 --> 00:43:24,660
+أبقى mainly normocytic لكنها eventually microcytic
+
+505
+00:43:24,660 --> 00:43:28,540
+بعض المرات بتصير microcytic السبب inflammatory
+
+506
+00:43:28,540 --> 00:43:33,020
+disease أو cancer شو بيصير؟ قالوا بيصير في low
+
+507
+00:43:33,020 --> 00:43:39,400
+iron concentration وهذا كله بيتوافق مع الانيميا
+
+508
+00:43:39,400 --> 00:43:44,360
+iron deficiency anemiaلكن بنلاحظ أنه في اختلافات
+
+509
+00:43:44,360 --> 00:43:49,080
+بدت تظهر على الخط زي الفررتين بزيد و ال transferin
+
+510
+00:43:49,080 --> 00:43:53,820
+بقلب و ال iron store بصفشا بمعنى normal or
+
+511
+00:43:53,820 --> 00:43:57,780
+increased و هذه كلها بتختلف عن ايش عن iron
+
+512
+00:43:57,780 --> 00:44:01,540
+deficiency أنيميا و ده الجدول مبين للاختلافات ما
+
+513
+00:44:01,540 --> 00:44:05,540
+بين الانيميا و ال micro disorder ال ACD و ما بين
+
+514
+00:44:05,540 --> 00:44:10,840
+الفرق او ال iron deficiency أنيميا ماشي اخر واحد
+
+515
+00:44:10,840 --> 00:44:11,180
+اللي هو ال
+
+516
+00:44:14,320 --> 00:44:19,420
+برضه بيبقى احد ال marker اليوم مستخدم في التشخيص
+
+517
+00:44:19,420 --> 00:44:23,060
+والتفريق بينهم في ال ACD بيلاقي عالي في الانيميا
+
+518
+00:44:23,060 --> 00:44:29,520
+ايرن دفاشنسيا انيميا بيلاقي واطي سيدرو
+
+519
+00:44:29,520 --> 00:44:33,680
+بلاستيك انيميا من الاسم هي عبارة عن heterogeneous
+
+520
+00:44:33,680 --> 00:44:39,320
+group of disorders بتتميز بوجود خلل في ال
+
+521
+00:44:39,320 --> 00:44:43,900
+incorporation of iron within the brainيعني في خلال
+
+522
+00:44:43,900 --> 00:44:48,820
+في دخول ال iron في ال .. لتكوين ايه؟ لتكوين ايش؟
+
+523
+00:44:48,820 --> 00:44:53,300
+لتكوين هيم؟ احنا قلنا المركب اللي جاب للهيم هو ال
+
+524
+00:44:53,300 --> 00:44:57,580
+proto porphyrin اخر خطوة انه بيضل على ال iron و
+
+525
+00:44:57,580 --> 00:45:01,420
+نخش في ال proto porphyrin فبتحول لهيم طب في خلال
+
+526
+00:45:01,420 --> 00:45:04,760
+في هذه الخطوة يبقى فيه heme synthesis في الشيم
+
+527
+00:45:04,760 --> 00:45:13,120
+ماشي ففي proto porphyrin بزيدوببدأ الـ iron في هذه
+
+528
+00:45:13,120 --> 00:45:20,880
+الحالة مدام موجود لكنه لا في خلل في دخوله لتصنيع
+
+529
+00:45:20,880 --> 00:45:25,700
+ال heme وبالتالي بيبدأ يتجمع ال iron في
+
+530
+00:45:25,700 --> 00:45:33,280
+الميتوكندريةوتجمعوا في داخل ال RBC سوري وبالتالي
+
+531
+00:45:33,280 --> 00:45:36,260
+بيتجمع حوالين ال mitochondria، encircling the
+
+532
+00:45:36,260 --> 00:45:40,120
+mitochondria وبيعمل حاجة بسموها Ringed Sidroblast،
+
+533
+00:45:40,120 --> 00:45:44,400
+شو بسموها؟ Ringed يعني دائرة، Sidroblast، الخلية
+
+534
+00:45:44,400 --> 00:45:52,110
+صار فيها Ironوهذا مدام اتحول او تحلق حوالين الـ
+
+535
+00:45:52,110 --> 00:45:55,430
+mitochondria بيعمل حاجة بتصير ال RBC's غير طبيعية
+
+536
+00:45:55,430 --> 00:45:59,230
+فبتموت فبيعمل حاجة باسمها ineffective arthroposis
+
+537
+00:45:59,230 --> 00:46:04,150
+لكن هذه الظاهرة اللي هي ringed syndroblast بنشوفها
+
+538
+00:46:04,150 --> 00:46:09,290
+في حالة أنيمية تانية مش بس في حالة syndroblastic
+
+539
+00:46:09,290 --> 00:46:15,590
+anemia طيب قسموها إلى القادي hereditary type
+
+540
+00:46:21,200 --> 00:46:27,580
+الخلايا اللي بيترسب فيها الحديد لأنه لم يستغل ما
+
+541
+00:46:27,580 --> 00:46:31,560
+استغلنهوش في تصنيع الهيم فبدأ يترسب على الخلايا
+
+542
+00:46:31,560 --> 00:46:35,560
+ماشي و هذه عبارة عن الخلايا اللي ممكن احنا نشوفها
+
+543
+00:46:35,560 --> 00:46:41,240
+ببساطة في blood film مسبوخ ب iron stain ايش ال
+
+544
+00:46:41,240 --> 00:46:42,960
+iron stain شهير؟
+
+545
+00:46:49,370 --> 00:46:52,530
+طيب ايش ال Sidrocite و Sidroblast مصطلحات جديدة
+
+546
+00:46:52,530 --> 00:46:54,710
+يعني لأن ال Sidrocite هي عبارة عن mature
+
+547
+00:46:54,710 --> 00:46:57,690
+herbaceous لكن فيها واحد او اكتر من واحد من ال
+
+548
+00:46:57,690 --> 00:47:03,010
+Sidrotic granules او بيسموه Papenhymer normal
+
+549
+00:47:03,010 --> 00:47:06,410
+Sidroblast
+
+550
+00:47:06,410 --> 00:47:13,270
+nucleated red blood cell تحتوي على واحد او اكتر من
+
+551
+00:47:13,270 --> 00:47:21,910
+Sidrotic granules usually difficult to seeوانتشرت
+
+552
+00:47:21,910 --> 00:47:26,890
+بشكل محدد في الـ cytoplasm وغالباً
+
+553
+00:47:26,890 --> 00:47:32,410
+بنشوفها .. بنشوفها اشبتنعدم يعني في حالات الـ iron
+
+554
+00:47:32,410 --> 00:47:37,130
+deficiency أنيميا او في حالة ال chronic disorders
+
+555
+00:47:37,130 --> 00:47:45,330
+لكن ال abnormal Sidroblast بيكون فيه ايرون كتير
+
+556
+00:47:45,330 --> 00:47:50,470
+فبصير في ال رتين iron depositionوفر تنقيق
+
+557
+00:47:50,470 --> 00:47:56,830
+aggregates فبزيد ال granules ماشي و بتصير ال
+
+558
+00:47:56,830 --> 00:48:02,170
+granules larger and larger و بتبدأ تتحلق ال
+
+559
+00:48:02,170 --> 00:48:06,090
+mitochondria و بيسموا هذه ال granules ال acidotic
+
+560
+00:48:06,090 --> 00:48:11,510
+granules ماشي اللي ممكن نشوفها في حالات أنيمة
+
+561
+00:48:11,510 --> 00:48:16,820
+مختلفةنبدأ بالأول نوع وهو الـ Hereditary يعني الـ
+
+562
+00:48:16,820 --> 00:48:21,220
+Hereditary هو عبارة عن X-linked type of inherited
+
+563
+00:48:21,220 --> 00:48:26,020
+disease غالبا بيتميز بوجود functional deficiency
+
+564
+00:48:26,020 --> 00:48:34,360
+لإنزايم اللي بتصنع ال heme-synthetic pathway أهمها
+
+565
+00:48:35,780 --> 00:48:40,080
+هو عبارة عن Delta-aminolucric acid synthetase وهو
+
+566
+00:48:40,080 --> 00:48:44,700
+عبارة عن إنزايم بيبدأ في أول سلسلة تصنيع الهيم أو
+
+567
+00:48:44,700 --> 00:48:49,340
+الferrochilates وهو عبارة عن الإنزايم المسؤول عن
+
+568
+00:48:49,340 --> 00:48:53,950
+تدخيل ال iron فيهاشفي الـPotoporphin وتكوين الهيوم
+
+569
+00:48:53,950 --> 00:48:59,810
+.مافيش الانزيمات هذه، مافيش استغلال لمين للـIron
+
+570
+00:48:59,810 --> 00:49:06,210
+وبالتالي بيصير في الصدر تجمهات للـIron في الخلايا
+
+571
+00:49:06,210 --> 00:49:14,090
+.الـaffected male had hypochromic diphoric anemia.
+
+572
+00:49:16,620 --> 00:49:20,640
+يعني فيه hypochromia وdiamorphic يعني فيه شكلين من
+
+573
+00:49:20,640 --> 00:49:25,180
+أنواع الاربسيز ماشي with mild ineffective
+
+574
+00:49:25,180 --> 00:49:28,900
+erythropoiesis and erythroid hyperplasia
+
+575
+00:49:28,900 --> 00:49:33,120
+ineffective erythropoiesis احنا عرفناه عشان
+
+576
+00:49:33,120 --> 00:49:37,580
+المصطلح بتموت الخلايا بدري في داخل الممارس وفي
+
+577
+00:49:37,580 --> 00:49:41,480
+erythroid hyperplasia hyper يعني زيادة في تصميم ال
+
+578
+00:49:41,480 --> 00:49:46,420
+erythroid seriesمن أيضًا الأنواع اللي هي led
+
+579
+00:49:46,420 --> 00:49:50,520
+poisoning اللي ال acquired من الإسم led poisoning
+
+580
+00:49:50,520 --> 00:49:54,700
+يعني فيه دخول لل led في الجسم زيادة عن اللزوم
+
+581
+00:49:54,700 --> 00:50:01,320
+غالبًا زمان كنا نشوفه يوم كانت تجينا الميه في
+
+582
+00:50:01,320 --> 00:50:06,620
+أنابيب من الرصاص لكن اليوم استبدلوا كل مؤثير
+
+583
+00:50:06,620 --> 00:50:13,020
+المياه ب plastic pipes فبالتالييعني قلت هذه
+
+584
+00:50:13,020 --> 00:50:19,060
+الظاهرة لكن لازالت موجودة في بعض الاش كضريبة من
+
+585
+00:50:19,060 --> 00:50:24,400
+ضرائب المهن المختلفة زي الناس اللي بتشتغل في
+
+586
+00:50:24,400 --> 00:50:30,580
+المحطات البترول لإن معظم البترول مليان من اللي لحق
+
+587
+00:50:30,580 --> 00:50:35,820
+بالرصاص أو اللي بيشتغلوا في البوية البوياجية لإن
+
+588
+00:50:35,820 --> 00:50:40,820
+برضه معظم البوية فيها رصاص و هكذاطيب كان بيخش
+
+589
+00:50:40,820 --> 00:50:43,920
+الجسم اللى انت جاله بيخش عن طريقتين .. بالطريقتين
+
+590
+00:50:43,920 --> 00:50:47,580
+إما by inhalation يعني أنت ممكن تستنشقه أو by
+
+591
+00:50:47,580 --> 00:50:54,140
+ingestion أو تاخده بيخش الجسم و .. متى ما دخل
+
+592
+00:50:54,140 --> 00:50:57,600
+الجسم بيصيرله accumulation بيترسق في ال bone و ال
+
+593
+00:50:57,600 --> 00:51:02,440
+bone marrow و طبعا في ال bone marrow هناك فيه
+
+594
+00:51:02,440 --> 00:51:06,940
+electrode precursor cell وبيتحلق ال mitochondrial
+
+595
+00:51:06,940 --> 00:51:13,930
+membraneوبعمل disruption للـ heme synthesis وهذا
+
+596
+00:51:13,930 --> 00:51:19,490
+بيؤدي إلى Sidroplastic changes وطبعا بيأثر على
+
+597
+00:51:19,490 --> 00:51:24,430
+الردس الممبرين و أيضا يمنع ال glycolytic activity
+
+598
+00:51:24,430 --> 00:51:29,490
+وبالتالي يقلل من ال life span تبعتها هذا بيؤدي إلى
+
+599
+00:51:29,490 --> 00:51:34,050
+mild hemolysis وبيؤدي إلى أنيميا و chronic lead
+
+600
+00:51:34,050 --> 00:51:40,590
+poisoning كيف ممكن نشخصها؟نفحص للـ LED by chemical
+
+601
+00:51:40,590 --> 00:51:45,630
+test أو بندور على الـ protoporphene ما هو المرحلة
+
+602
+00:51:45,630 --> 00:51:52,990
+التي تسبق الهيلة، بنزيد في هذه الحالة أو بنصور
+
+603
+00:51:52,990 --> 00:51:59,240
+المريضلأن صورة الأشياء العادية لأن الرصاص يوم ما
+
+604
+00:51:59,240 --> 00:52:02,900
+يكون موجود ومترثب في ال gastrointestinal tract على
+
+605
+00:52:02,900 --> 00:52:08,960
+سبيل المثال بيبين ك .. ك radio opaque fragments
+
+606
+00:52:08,960 --> 00:52:18,300
+يعني .. يعني فراغ أبيض في صورة الأشياء أيضا
+
+607
+00:52:18,300 --> 00:52:24,220
+ممكن احنا نصور العضم وبرضه العضمممكن نشوف الرصاص
+
+608
+00:52:24,220 --> 00:52:26,780
+المترسم فيه لأنه قلنا في ال bone و ال bone marrow
+
+609
+00:52:26,780 --> 00:52:32,220
+ممكن يترسم نوع التاني اللي هو ال acquired او ال
+
+610
+00:52:32,220 --> 00:52:35,780
+secondary citro plastic anemia في منها نوع اسمه
+
+611
+00:52:35,780 --> 00:52:39,040
+drug induced citro plastic anemia هو من اسم ال
+
+612
+00:52:39,040 --> 00:52:42,260
+drug يعني دخل ال drug عمل inhibition لل absorption
+
+613
+00:52:42,260 --> 00:52:46,120
+او ال inhibition لل enzyme اللي بتدخل او اللي
+
+614
+00:52:46,120 --> 00:52:52,800
+بتخدم تاخد ال iron و بتدخله بتكون في ال ريتينيعني
+
+615
+00:52:52,800 --> 00:52:55,460
+عامل inhibition لانوانزايم لان الانزيمين اللي طوا
+
+616
+00:52:55,460 --> 00:52:59,680
+حكيناهم delta-aminolucronic acid synthetase و
+
+617
+00:52:59,680 --> 00:53:04,200
+الferrochlates نفس الحكاية بس acquired هذه كانت
+
+618
+00:53:04,200 --> 00:53:11,660
+hereditary هذه المرة جاية due to إيش due to drug
+
+619
+00:53:11,660 --> 00:53:18,020
+ال mixture طبعا زيها زي اللي طوا حكيناهاطب فيه
+
+620
+00:53:18,020 --> 00:53:21,060
+other investigation قالوا أه ممكن ال urinary
+
+621
+00:53:21,060 --> 00:53:24,980
+coproporphin أحد المركبات اللي بيمر فيها تصنيع
+
+622
+00:53:24,980 --> 00:53:30,120
+الهيميا microcytic hypochromic anemia و هي بنطلع
+
+623
+00:53:30,120 --> 00:53:33,520
+على حاجة بيسموها mesophilic stippling و ال
+
+624
+00:53:33,520 --> 00:53:38,440
+mesophilic stippling بنشوفها في ال RBCs و بنشوف
+
+625
+00:53:38,440 --> 00:53:44,200
+reticulocytosis و ال mesophilic stippling
+
+626
+00:53:47,830 --> 00:53:53,290
+بيتجمع في الـcytoplasm وغالبا بيشوفه في
+
+627
+00:53:53,290 --> 00:53:58,230
+الـyoungest herpeses herpeses ليش؟ الحديثة
+
+628
+00:53:58,230 --> 00:54:03,110
+التصنيعة بيزوفيليكستيمليكي accumulation of
+
+629
+00:54:03,110 --> 00:54:08,050
+pyrimidine نيوتايد في داخل الـcytoplasm وفرسو
+
+630
+00:54:08,050 --> 00:54:12,810
+بلاستر نوع التالت اللي هو idiopathic cedroplastic
+
+631
+00:54:12,810 --> 00:54:18,230
+anemia due to unknown ودي اليوميعني زمان كانوا
+
+632
+00:54:18,230 --> 00:54:24,850
+يشوفوها في الـ Elderly People و بتعتبر اليوم نوع
+
+633
+00:54:24,850 --> 00:54:27,610
+من أنواع الـ Myelodysplastic Syndrome شلوها من
+
+634
+00:54:27,610 --> 00:54:35,070
+تصنيفات الانيميا و بيسموها Refractory Anemia with
+
+635
+00:54:35,070 --> 00:54:41,810
+Ringed Syndroblast تتميز بـ Dysarthropic Changes
+
+636
+00:54:41,810 --> 00:54:48,080
+في MacrocytosisPoikilocytosis بيزوفيليكستبليك
+
+637
+00:54:48,080 --> 00:54:55,380
+رينغسيدروبلاست وطبعا تتأخرت الاريثروبلاست في ندوشة
+
+638
+00:54:55,380 --> 00:55:00,140
+في المراحل المبكرة كمان ال platelet و ال leukocyte
+
+639
+00:55:00,140 --> 00:55:07,000
+بنشوفهم بشكل طبيعي هذا لغاية الأن كل ما يتعلق بقلة
+
+640
+00:55:07,000 --> 00:55:13,740
+ال iron مشاكل ينتج عنها أو أنيميا متختلفة الأنواع
+
+641
+00:55:13,980 --> 00:55:18,840
+نجى عن قلة في الايران طيب في disorders اللي علاقة
+
+642
+00:55:18,840 --> 00:55:22,160
+بزيادة الايران اه طبعا اذا كان فيه زيادة في انتصاص
+
+643
+00:55:22,160 --> 00:55:27,860
+الحديد في الجسم هو الحديد مشكلة انتصاصه قالوا فيه
+
+644
+00:55:27,860 --> 00:55:36,780
+3 حالات ممكن نشوفها بتنتج عن زيادة الحديد نمر واحد
+
+645
+00:55:36,780 --> 00:55:42,420
+hereditary hemochromatosis طبعا الاسم واضح جدا
+
+646
+00:55:42,420 --> 00:55:43,080
+heme
+
+647
+00:55:46,360 --> 00:55:50,380
+Hemochromatosis بمعنى انه فيه زيادة في لون الخلايا
+
+648
+00:55:50,380 --> 00:55:56,620
+اللى موجود اللى اللى اللى اللى اللى اللى اللى اللى
+
+649
+00:55:56,620 --> 00:55:57,620
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+650
+00:55:57,620 --> 00:55:57,740
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+651
+00:55:57,740 --> 00:55:57,880
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+652
+00:55:57,880 --> 00:55:58,380
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+653
+00:55:58,380 --> 00:55:58,400
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+654
+00:55:58,400 --> 00:55:58,860
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+655
+00:55:58,860 --> 00:56:00,920
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+656
+00:56:00,920 --> 00:56:00,980
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+657
+00:56:00,980 --> 00:56:11,040
+اللى اللى اللى اللى اللى اللى اللى اللى
+
+658
+00:56:11,040 --> 00:56:15,280
+اللىنقول إنها دم زيادة عن الزومي النوع التالت
+
+659
+00:56:15,280 --> 00:56:18,840
+بيصير فيه Hemochromatosis ناتج عن إيه؟ إيش عن
+
+660
+00:56:18,840 --> 00:56:22,420
+الأكل؟ يعني بناخد كميات كبيرة من الحديد دون أن
+
+661
+00:56:22,420 --> 00:56:26,440
+ندرى أول هذه الأنواع Hereditary Hemochromatosis
+
+662
+00:56:26,440 --> 00:56:30,200
+ناتج عن إيه؟ إيش؟ هو عبارة عن multi-organ disease
+
+663
+00:56:30,200 --> 00:56:36,220
+inherited in an autosomal recessive manner وهي
+
+664
+00:56:36,220 --> 00:56:40,020
+بيعتبر most common genetic disease في ال northern
+
+665
+00:56:40,020 --> 00:56:44,950
+Europeواللي بيصير فيه انه بيصير فيه excessive
+
+666
+00:56:44,950 --> 00:56:49,470
+absorption لل iron وبالتالي بيبقى يخش ال iron في
+
+667
+00:56:49,470 --> 00:56:53,450
+داخل الجسم وبيبدأ يترسب على ال tissue زي ال
+
+668
+00:56:53,450 --> 00:56:57,730
+pancreas و ال heart و ال liver و إذا ترسب عليها هي
+
+669
+00:56:57,730 --> 00:57:02,190
+طبعا بتصير الأعضاء هذه dysfunctional في الوضع
+
+670
+00:57:02,190 --> 00:57:05,870
+الطبيعي ال iron تركيزه من اتنين لستة جرام قلنا
+
+671
+00:57:05,870 --> 00:57:10,180
+أربعة في الميللكن في حالات مرض من هنوع
+
+672
+00:57:10,180 --> 00:57:14,400
+Hemochromatosis بوصل ال concentration تبعته من 50
+
+673
+00:57:14,400 --> 00:57:21,860
+ل 60 gram هذه الأنواع تبعت ال Hemochromatosis ال
+
+674
+00:57:21,860 --> 00:57:28,480
+hereditary type ناتجة عن خلل في بعض الانزيمات طبعا
+
+675
+00:57:28,480 --> 00:57:33,060
+الانزيمات عبارة عن proteins و ال proteins المسؤول
+
+676
+00:57:33,060 --> 00:57:37,300
+عن تصنيعه gene فأي خلل في هذه ال gene غيابه
+
+677
+00:57:39,880 --> 00:57:43,880
+الـ Chromatosis كلها هذه الانزيمات بتلعب دور كبير
+
+678
+00:57:43,880 --> 00:57:49,140
+في عملية امتصاص الـ Iron إذا صار فيها خلال منة ال
+
+679
+00:57:49,140 --> 00:57:54,540
+Iron بيمتص بكميات كبيرة شو بيصير؟ pathophysiology
+
+680
+00:57:54,540 --> 00:57:58,600
+طبعا في هذا الحالة بيصير زيادة في percent of
+
+681
+00:57:58,600 --> 00:58:04,600
+saturation و transferrin وهي بالتالي بيزيد ال iron
+
+682
+00:58:04,600 --> 00:58:06,420
+absorption in the circulation
+
+683
+00:58:08,790 --> 00:58:12,870
+وبالتالي الترانسفرن بيبقى القادر على أنه ينقل
+
+684
+00:58:12,870 --> 00:58:21,870
+الحديد واحنا بنعرف أنه 30% من ال circulating iron
+
+685
+00:58:21,870 --> 00:58:26,770
+بينقل عن طريق الترانسفرن لكن في هذا الحالة كل
+
+686
+00:58:26,770 --> 00:58:28,010
+الترانسفرن مشغول
+
+687
+00:58:30,980 --> 00:58:37,780
+و these ionic iron acts as a catalyst for
+
+688
+00:58:37,780 --> 00:58:41,400
+formation of toxic oxygen radical in the presence
+
+689
+00:58:41,400 --> 00:58:47,420
+of NADH طبعا بيصير فيه free radical compoundوالـ
+
+690
+00:58:47,420 --> 00:58:49,620
+Free Radical Compound هي عبارة عن هايري توكسيك
+
+691
+00:58:49,620 --> 00:58:54,760
+سوبستانس بتهاجم أعضاء الجسم المختلفة وبالتالي ..
+
+692
+00:58:54,760 --> 00:58:57,940
+اللي .. عبارة عن اللي اترسم عليها العيرون وبالتالي
+
+693
+00:58:57,940 --> 00:59:06,780
+بيصير فيه dysfunctional or infarctional organ أشهر
+
+694
+00:59:06,780 --> 00:59:09,740
+الـ Free Radical Compound اللي بتتكون هي الـ
+
+695
+00:59:09,740 --> 00:59:17,310
+Hydroxy Radical Compound Laboratory findingبصير في
+
+696
+00:59:17,310 --> 00:59:21,790
+ريز سيرام 13 ردوس total iron binding capacity
+
+697
+00:59:21,790 --> 00:59:28,070
+وطبعا ال iron binding saturation بتزيد لأكتر من 60
+
+698
+00:59:28,070 --> 00:59:33,010
+% في ال male و أكتر من 50% في ال female لو خدنا
+
+699
+00:59:33,010 --> 00:59:36,610
+liver biopsy هنلاقي فيه زيادة في ال iron deposit
+
+700
+00:59:38,980 --> 00:59:44,120
+execution of secondary causes ممكن يتم من خلال عمل
+
+701
+00:59:44,120 --> 00:59:50,740
+blood film و مرات نحتاج نعمل bone marrow و في هذه
+
+702
+00:59:50,740 --> 00:59:56,140
+الحالة لازم نعمل screening للشخص اللي طلع عنده
+
+703
+00:59:56,140 --> 01:00:00,400
+hemochromatosis و كل عائلته كل for genetic
+
+704
+01:00:00,400 --> 01:00:07,100
+counselingهذه صورة لواحدة العظام تبعته صار فيها
+
+705
+01:00:07,100 --> 01:00:12,420
+ترسب لكميات كبيرة المفاصل في المفاصل لل iron وفي
+
+706
+01:00:12,420 --> 01:00:18,700
+بعض المناطق صار فيه اللي هو erogen فقدان لبعض
+
+707
+01:00:18,700 --> 01:00:23,880
+العظام اللي موجودة في بعض المفاصل هذا هو أيها
+
+708
+01:00:23,880 --> 01:00:29,900
+المفقودة صار في فقدان لل cartridge هذه صورة ل
+
+709
+01:00:29,900 --> 01:00:36,180
+liverفيها طبعا اللون الأزرق هذا بيعني انه في كميات
+
+710
+01:00:36,180 --> 01:00:40,380
+كبيرة من ال iron symptoms
+
+711
+01:00:40,380 --> 01:00:43,800
+Arthralgia
+
+712
+01:00:43,800 --> 01:00:52,260
+و من الاسم هذه بتكون مصحوبة من joint arthritis ثم
+
+713
+01:00:52,260 --> 01:00:56,620
+gonad ال failure both gonads سواء كان testary or
+
+714
+01:00:56,620 --> 01:01:01,340
+ovary بيصير لهم atrophyفى ال male بيصير فى
+
+715
+01:01:01,340 --> 01:01:06,920
+impotence و فى ال female بيصير فى amenorrhea بيصير
+
+716
+01:01:06,920 --> 01:01:11,380
+فى skin pigmentation طبعا تلون ال skin و طبعا
+
+717
+01:01:11,380 --> 01:01:14,320
+cardiac failure و arrhythmias، arrhythmias يعني
+
+718
+01:01:14,320 --> 01:01:18,380
+خلل فى ضربات القلب ثم ضيابيتس إذا كان اترسب على
+
+719
+01:01:18,380 --> 01:01:25,320
+البنجرياز ثم ثم
+
+720
+01:01:25,320 --> 01:01:31,330
+cirrhosis و abdominal painTreatment بيعملوا vein
+
+721
+01:01:31,330 --> 01:01:38,030
+section لكل ال iron اللي موجود و اليوم طبعا صاروا
+
+722
+01:01:38,030 --> 01:01:43,030
+يستخدموا iron chelating agent اللي هو الدسفرال و
+
+723
+01:01:43,030 --> 01:01:48,950
+هي عبارة عن مادة بتحقن في المريض و بالتالي بيبدأ
+
+724
+01:01:48,950 --> 01:01:56,630
+يعمل chelation لكل ال iron ال prognosis اللي بيصير
+
+725
+01:01:56,630 --> 01:02:01,220
+فيه arthropathyبصير فيه hypogonadism بصير فيه
+
+726
+01:02:01,220 --> 01:02:09,460
+hepatic cirrhosis وغالبا ما
+
+727
+01:02:09,460 --> 01:02:16,640
+بتتحسن بالعلاج يوم ما انعالج المرضى يعني المرضى
+
+728
+01:02:16,640 --> 01:02:18,760
+اللى بتعالجه بالكميات كاميرة
+
+729
+01:02:40,770 --> 01:02:46,990
+مقارنة بـ 67% من الذين لم يتم علاجهم يعني الناس
+
+730
+01:02:46,990 --> 01:03:00,330
+اللي نديهم علاج مكثف 11% منهم عاش خمس سنوات زيادة
+
+731
+01:03:01,920 --> 01:03:09,160
+بالمقابل 67% من اكتر من الناس اللي 67% طبعا
+
+732
+01:03:09,160 --> 01:03:14,080
+مااخدوش العداج ايه بقى توصله ل carcinoma, cardiac
+
+733
+01:03:14,080 --> 01:03:20,180
+disease ال liver failure all caused by this النوع
+
+734
+01:03:20,180 --> 01:03:22,420
+التاني من ال hemochromatosis الناس اللي بتاخد كمية
+
+735
+01:03:22,420 --> 01:03:27,620
+دم كتيرة اتفقنا على نوحدة الدم فيها 250 ميلي جرام
+
+736
+01:03:27,980 --> 01:03:32,020
+من ال iron وبالتالي الناس اللي بتاخد كميات كبيرة
+
+737
+01:03:32,020 --> 01:03:36,300
+من الدم بيترسم فيها ال iron بكميات كبيرة نوع
+
+738
+01:03:36,300 --> 01:03:40,580
+التالت dietary cause طبعا ال dietary ممكن يصير عن
+
+739
+01:03:40,580 --> 01:03:49,460
+طريق الأكل بيخش الأكل طبعا و هذا حالات سجنة زيادة
+
+740
+01:03:49,460 --> 01:03:56,420
+ال iron للناس اللي بتطبخ في أواني حديدية اوفي بعض
+
+741
+01:03:56,420 --> 01:03:59,400
+المرات بيشير في acute iron poisoning الناس اللي ..
+
+742
+01:03:59,400 --> 01:04:03,580
+الأطفال اللي بيشربوا اللي هو الكميات كبيرة من ال
+
+743
+01:04:03,580 --> 01:04:07,080
+iron أو الناس اللي بتحاول تنتحر فبتاخد كميات كبيرة
+
+744
+01:04:07,080 --> 01:04:14,160
+من حبوب الحديد ال .. ال chronic use كمان of iron
+
+745
+01:04:14,160 --> 01:04:17,040
+supplementation في كناس كتير بتاخد أكتر من course
+
+746
+01:04:17,040 --> 01:04:22,330
+من courses الحديد وبالتالي بيبدأ بيأثر تأثيريزيد
+
+747
+01:04:22,330 --> 01:04:30,430
+الحديد في الجسم و بهيك بيكون انتهينا من المحاضرة
+
+748
+01:04:30,430 --> 01:04:36,370
+التانية ارجو ان تكونوا قد استمتعتم فيها
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4ed0975ca6b242dce70bd7ec36674e5541e041e0
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/nt5sVxbV750_raw.srt
@@ -0,0 +1,2992 @@
+1
+00:00:04,390 --> 00:00:10,130
+بسم الله الرحمن الرحيم اترفنا أولا في المحاضرة
+
+2
+00:00:10,130 --> 00:00:14,910
+السابقة على ال hemopoiesis و كيفية تصنيع الخلايا و
+
+3
+00:00:14,910 --> 00:00:20,590
+نبدأ الآن في بعض ال disorders متمثلة بأنواع مختلفة
+
+4
+00:00:20,590 --> 00:00:25,870
+من ال anemia و هنبدأ بال nutritional anemia يعني
+
+5
+00:00:25,870 --> 00:00:31,670
+ال anemia اللي ناتجة عن نقص في nutrition العوامل
+
+6
+00:00:31,670 --> 00:00:37,210
+الأكل يعنيو أشهر هذه الأنواع من ال anemia هي iron
+
+7
+00:00:37,210 --> 00:00:44,710
+deficiency anemia هنتفق على أسلوب شريح في هذا
+
+8
+00:00:44,710 --> 00:00:51,070
+الموضوع و هو ان
+
+9
+00:00:51,070 --> 00:00:53,670
+شاء الله احنا نتطرق لل chemistry of
+
+10
+00:00:56,630 --> 00:01:01,870
+عليه ثم من خلال ال chemistry هنتفهم دوره و نشوف
+
+11
+00:01:01,870 --> 00:01:07,210
+مواقع ال defect اللي بتصير وبالتالي مواقع الخلل
+
+12
+00:01:07,210 --> 00:01:15,250
+اللي بدها تنتج منها او عنها العنيميا الأشهر
+
+13
+00:01:15,250 --> 00:01:18,650
+هأ دى الأنواع زى ما قلتلكوا ال iron deficiency
+
+14
+00:01:18,650 --> 00:01:24,590
+عنيميا وبالتالي هنبدأ بال role of iron في الجسم
+
+15
+00:01:30,370 --> 00:01:34,970
+نبدأ على بركة الله وين موجود ال iron؟ ال iron
+
+16
+00:01:34,970 --> 00:01:39,510
+compound involved in cellular في موقعين مهمين موقع
+
+17
+00:01:39,510 --> 00:01:43,450
+الأولاني cellular metabolism يعني في الخلايا و
+
+18
+00:01:43,450 --> 00:01:48,090
+نشاط الخلايا و بالنجيم موجود في ال heme و ال iron
+
+19
+00:01:48,090 --> 00:01:54,150
+compound وين في ال heme؟ في تصنيع ال hemoglobin
+
+20
+00:01:55,660 --> 00:02:01,760
+واللي موجلبن carrying compound فبنلاقي فيه ايرون
+
+21
+00:02:01,760 --> 00:02:06,420
+للميوجلبن اصلا oxygen carrying compound برضه
+
+22
+00:02:06,420 --> 00:02:10,440
+مولودة في ال muscles ثم في certain انزايم زي
+
+23
+00:02:10,440 --> 00:02:14,520
+الستاكرومز وهي برعنة air electron transport enzyme
+
+24
+00:02:14,520 --> 00:02:20,040
+for oxidation المكان
+
+25
+00:02:20,040 --> 00:02:22,600
+التاني اللي موجود في ال cellular اللي هو نانهيم
+
+26
+00:02:23,060 --> 00:02:27,100
+ووجدوه في certain enzymes زي الـ NADPH أو الـ NADH
+
+27
+00:02:27,100 --> 00:02:30,720
+enzyme و الـ succinic dehydrogenase enzyme والتاني
+
+28
+00:02:30,720 --> 00:02:36,220
+المهمين في عمليات اللي هو سواء كانت ال iron
+
+29
+00:02:36,220 --> 00:02:41,820
+metabolism أو ال heme synthesis موقع تاني اللي
+
+30
+00:02:41,820 --> 00:02:46,240
+بنلاحظ في وجود ال iron هو ال compound which is
+
+31
+00:02:46,240 --> 00:02:51,320
+required which are required for iron storage و
+
+32
+00:02:53,680 --> 00:02:57,020
+يعني اللخصوها في تلت عوامل هي الـ Transferrin و ال
+
+33
+00:02:57,020 --> 00:03:03,340
+Hemocydrine و الفرّتين ما هو مخزون ال Iron في
+
+34
+00:03:03,340 --> 00:03:06,820
+الجسم قالوا ال Iron بيتكوّن في الجسم من أربعة جرام
+
+35
+00:03:06,820 --> 00:03:12,740
+في أربعة جرام Iron في الجسم تلت ترباعها موجودة as
+
+36
+00:03:12,740 --> 00:03:16,640
+Oxygen Carrying Compound Oxygen Carrying Compound
+
+37
+00:03:16,640 --> 00:03:21,370
+سواء كانت Hemoglobin أو Myoglobinيعني في ال blood
+
+38
+00:03:21,370 --> 00:03:28,390
+circulation أو في .. في ال muscle الربع الباقي هو
+
+39
+00:03:28,390 --> 00:03:32,550
+عبارة عن iron stores عبارة عن ايش؟ iron stores
+
+40
+00:03:32,550 --> 00:03:37,790
+وقسموها بالشكل هذا هي circulating هموجلبن 60% body
+
+41
+00:03:37,790 --> 00:03:44,130
+stores 25% ال circulating hemoglobin والميoglobin
+
+42
+00:03:44,130 --> 00:03:50,070
+10% 60% و7% و10% و70%تقريبا تلات ترباع والربع
+
+43
+00:03:50,070 --> 00:03:54,950
+الباقي هو ال 25 body stores ده ال 5% وجدوا 4% منها
+
+44
+00:03:54,950 --> 00:03:58,490
+في ال bone marrow واحد في المية enzyme وأقل من
+
+45
+00:03:58,490 --> 00:04:01,570
+point one موجود في البلازمة يعني circulating
+
+46
+00:04:01,570 --> 00:04:09,270
+البلازمة هيهم برضه مصنفة في جدوة أخر ال hemoglobin
+
+47
+00:04:09,270 --> 00:04:15,170
+حوالي 2500 milligram طبعا هذا ال male و هذا ال
+
+48
+00:04:15,170 --> 00:04:18,910
+female بتكون تعرفواإنه في فرق ما بين ال male و ال
+
+49
+00:04:18,910 --> 00:04:22,770
+female concentration
+
+50
+00:04:22,770 --> 00:04:28,730
+و طبعا ال male أكتر من ال female في
+
+51
+00:04:28,730 --> 00:04:33,120
+الهيموجلوبين في ال male حوالي 2500 ميلي جرام وهذا
+
+52
+00:04:33,120 --> 00:04:36,160
+بيه طبعا لأنه الهيموجلوبين في ال male أكتر من ال
+
+53
+00:04:36,160 --> 00:04:42,580
+female ال female 1700 ميجلوبين 500 برضه المصل أكتر
+
+54
+00:04:42,580 --> 00:04:48,500
+عند ال male في ال female 300 سيرام ايران 3 ميلي
+
+55
+00:04:48,500 --> 00:04:53,480
+جرام و ال iron stores من 500 لأقل عند ال male بما
+
+56
+00:04:53,480 --> 00:05:00,380
+لا يتجاوز ال 200 عند ال femaleالـ turnover of iron
+
+57
+00:05:00,380 --> 00:05:05,480
+بيتمثل بهذا ال figure ال iron وجدوا ان هو برعن one
+
+58
+00:05:05,480 --> 00:05:11,640
+way element بسله absorption و ب .. نمطس ال iron بس
+
+59
+00:05:11,640 --> 00:05:15,640
+بكمية قليلة من واحد لاتنين milligram daily و في
+
+60
+00:05:15,640 --> 00:05:21,200
+نفس الوقت نفقدهم عن طريق العرق ماشيطيب ها إيش
+
+61
+00:05:21,200 --> 00:05:27,060
+الحلقة هذه اللي بتدور فيها ال iron لأنه ال iron هو
+
+62
+00:05:27,060 --> 00:05:30,860
+عبارة عن مركب أساسي مكون أساسي لل hemoglobin و ال
+
+63
+00:05:30,860 --> 00:05:34,300
+hemoglobin موجودة في ال RBCs و بما أنه في عنا RBCs
+
+64
+00:05:34,300 --> 00:05:41,820
+كل يوم بتموت بكمية كبيرة و بيتصنع بدالها أيضا RBCs
+
+65
+00:05:41,820 --> 00:05:43,900
+بنفس الكمية لإنه في hemostasis
+
+66
+00:05:48,770 --> 00:05:53,190
+بتطلع من ال RBCs أيضًا بياخدها ال bone marrow مرة
+
+67
+00:05:53,190 --> 00:05:57,070
+تانية و بيصنع أن فيها RBCs فبالتالي فيه hemostasis
+
+68
+00:05:57,070 --> 00:06:06,090
+في ال iron turnover بالنسبالي ال myoglobin اللي
+
+69
+00:06:06,090 --> 00:06:08,570
+فيه 300 ميلي جرام و ال body store
+
+70
+00:06:12,290 --> 00:06:15,410
+هذه عوامل ثابتة اي يوم يكون الـ iron in excess
+
+71
+00:06:15,410 --> 00:06:19,590
+بصير عملية تخزين للـ iron في هذا المولود يبقى في
+
+72
+00:06:19,590 --> 00:06:23,470
+عندنا 10 over ثابت في عندنا hemostatic 10 over لل
+
+73
+00:06:23,470 --> 00:06:24,710
+iron كمية
+
+74
+00:06:28,830 --> 00:06:32,770
+ياخدوا البولمار و بيصنع فيه herbicides جديدة
+
+75
+00:06:32,770 --> 00:06:37,410
+وبالتالي بنفس الكمية وبالتالي مافقدش حاجة طبعا أيش
+
+76
+00:06:37,410 --> 00:06:41,270
+اللي بيطلع لو مافيش حاجة بتطلع فقط اللي بنفقده او
+
+77
+00:06:41,270 --> 00:06:45,730
+بيطلع منه هو عن طريق العرق و عن طريق ال urine و
+
+78
+00:06:45,730 --> 00:06:49,150
+الفيسيذ بيطلع شوية أيش اللي هو الكمية اللي احنا
+
+79
+00:06:49,150 --> 00:06:57,430
+بناخدها من الأكل WHO أيضا عملتاللي هو جدول بيبين
+
+80
+00:06:57,430 --> 00:07:01,690
+لي daily iron losses and requirement and في عمار
+
+81
+00:07:01,690 --> 00:07:08,750
+مختلفة وزي ما انتوا شايفين في انها daily loss في
+
+82
+00:07:08,750 --> 00:07:12,710
+ال urine و ال skin و ال feces و etc نفقدها فقطان
+
+83
+00:07:12,710 --> 00:07:17,930
+ماشي طبعا في ال female كمان في menses برضه تفقد
+
+84
+00:07:17,930 --> 00:07:26,270
+لكن بعد إيش بعد سن معين مجموع ما يفقدزائد مجموع ما
+
+85
+00:07:26,270 --> 00:07:34,570
+يحتاج الجسم يسمى الـ Total Iron Loss
+
+86
+00:07:37,240 --> 00:07:40,840
+و ال total iron loss المفروض ان هو total iron
+
+87
+00:07:40,840 --> 00:07:44,340
+requirement sorry وبالتالي هي هذه الجمهية المطلوبة
+
+88
+00:07:44,340 --> 00:07:50,080
+لإيش لكل إنسان في مرحلة من المرحل فعلى سبيل المثال
+
+89
+00:07:50,080 --> 00:07:55,160
+لو تاخدنا female عمرها 15 ل 17 سنة او 18 سنة في
+
+90
+00:07:55,160 --> 00:08:02,980
+المفروض تفقد تقريبا point 87 milligram
+
+91
+00:08:04,310 --> 00:08:07,770
+و في الmenses كمان تفقد حوالي point four في eight
+
+92
+00:08:07,770 --> 00:08:13,690
+لكنها في هذه السن لا تحتاج إلى نمو تفقدش اشي في
+
+93
+00:08:13,690 --> 00:08:17,390
+النمو فبالتالي الكمية اللى بتفقدها في هذا السن one
+
+94
+00:08:17,390 --> 00:08:20,630
+point three او بتحتاجها في هذا السن one point
+
+95
+00:08:20,630 --> 00:08:21,270
+three five
+
+96
+00:08:24,630 --> 00:08:27,430
+التالي Iron requirement زي ما اتفقنا هو عبارة عن
+
+97
+00:08:27,430 --> 00:08:30,590
+one way element يعني في absorption مافي execution
+
+98
+00:08:30,590 --> 00:08:34,710
+وبالتالي لابد من .. عشان نتحكم في هذا الموضوع لابد
+
+99
+00:08:34,710 --> 00:08:39,430
+من التحكم في ال absorption absorption is increased
+
+100
+00:08:39,430 --> 00:08:42,910
+in iron deficiency طبيعي يوم يقل ال iron بد الواحد
+
+101
+00:08:42,910 --> 00:08:47,130
+يمتص كمية أكبر and increase when body iron stores
+
+102
+00:08:47,130 --> 00:08:52,250
+are deleted برضه يوم تفضل مخازن بدنا ناخد air ناخد
+
+103
+00:08:52,250 --> 00:08:57,000
+iron أكتروبالتالي في قاعدة بتقول daily iron
+
+104
+00:08:57,000 --> 00:08:59,720
+requirement بتساوي ال amount lost زي ما شوفنا توفي
+
+105
+00:08:59,720 --> 00:09:04,920
+الجدول زي ال amount required طيب وقتاش بزيد الحاجة
+
+106
+00:09:04,920 --> 00:09:10,320
+لل iron يعني لو في ال female بيصير في menstruating
+
+107
+00:09:10,320 --> 00:09:13,880
+menstrual cycle شهرية
+
+108
+00:09:20,100 --> 00:09:24,700
+كل cycle ووجدوا ان هذه الكمية فيها من 15 ل 30
+
+109
+00:09:24,700 --> 00:09:31,680
+milligram يعني في كل one mil of blood في نص mil من
+
+110
+00:09:31,680 --> 00:09:37,760
+ال iron ايضا تفقد او تحتاج iron بكمية كبيرة
+
+111
+00:09:40,260 --> 00:09:44,940
+pregnancy يعني في fetus وبالتالي في fetal
+
+112
+00:09:44,940 --> 00:09:49,280
+placental growth وبالتالي في expansion لل blood
+
+113
+00:09:49,280 --> 00:09:54,680
+volume mother blood volume طبيعي الدورة الدموية
+
+114
+00:09:54,680 --> 00:10:00,280
+بتتضاعف ثم في نقطة مهمة جدا أو حرجة جدا وهي ال
+
+115
+00:10:00,280 --> 00:10:04,580
+hemorrhage in delivery كل female برضه تفقد كمية من
+
+116
+00:10:04,580 --> 00:10:11,220
+ال blood أثناء ولادها ال absorptionقالوا احنا
+
+117
+00:10:11,220 --> 00:10:15,840
+بنمتص حوالي خمسة لعشرة في المية من الحديد اللي
+
+118
+00:10:15,840 --> 00:10:19,440
+موجود في أكلنا جدش موجود حديد في أكلنا جاله من عشر
+
+119
+00:10:19,440 --> 00:10:24,700
+لخمستاشر ميلي جرام في اليوم طبعا ال .. ال ..
+
+120
+00:10:24,700 --> 00:10:29,000
+الحديد هذا موجود في أكلنا في ال .. في ال liver
+
+121
+00:10:29,000 --> 00:10:32,080
+يعني في الكبدة في ال red meat في ال green
+
+122
+00:10:32,080 --> 00:10:37,490
+vegetables ماعناش and supplemented cerealكل الحجوب
+
+123
+00:10:37,490 --> 00:10:44,430
+الـ fortified يعني اللي .. اللي مزودة
+
+124
+00:10:44,430 --> 00:10:51,730
+بالحديد and .. and fish ال dietary iron fall into
+
+125
+00:10:51,730 --> 00:10:56,550
+one of two category يا إما organic iron يا إما
+
+126
+00:10:56,550 --> 00:11:01,840
+inorganic iron طبعا ال inorganic iron هوأفضل
+
+127
+00:11:01,840 --> 00:11:05,240
+والميكانيزم تبعه معروف موجود في ال cereal و ال
+
+128
+00:11:05,240 --> 00:11:08,480
+vegetable و ال heme iron النوع التاني موجود في ال
+
+129
+00:11:08,480 --> 00:11:13,600
+.. في ال dairy و ال meat product كما تم عملية ال
+
+130
+00:11:13,600 --> 00:11:17,120
+absorption كانوا عملية ال absorption لل inorganic
+
+131
+00:11:17,120 --> 00:11:19,260
+usually
+
+132
+00:11:23,060 --> 00:11:27,160
+بتحسن في وجود reducing agent واش بيعمل ال reducing
+
+133
+00:11:27,160 --> 00:11:29,860
+agent؟ جاله reducing agent بزود ال solubility
+
+134
+00:11:29,860 --> 00:11:36,880
+وبالتالي بتكون complexes مع ال iron with this
+
+135
+00:11:36,880 --> 00:11:40,780
+reducing agent وبتم امتصاصها بسهولة أشهر ال
+
+136
+00:11:40,780 --> 00:11:44,620
+reducing agent هو ال ascorbic acid و الفيتا
+
+137
+00:11:44,620 --> 00:11:51,520
+والفروكتوز أيضا في glucose و succinate كلها عبارة
+
+138
+00:11:51,520 --> 00:11:52,100
+عناشر
+
+139
+00:11:55,260 --> 00:12:00,580
+الـ Reducing agent على عكس ذلك يمنع امتصاص الـ
+
+140
+00:12:00,580 --> 00:12:03,340
+Iron في وجود الـ Chelating agent أو الـ Chelating
+
+141
+00:12:03,340 --> 00:12:07,960
+agent ماذا تفعل هذه؟ تجعلها تكوّن Complexes يعني
+
+142
+00:12:07,960 --> 00:12:13,280
+يصعب امتصاصها يصعب امتصاصها زي ايش؟ زي وجود
+
+143
+00:12:13,280 --> 00:12:19,860
+الفوسفيت والفايتيت هذه عبارة عن موادالكالعين بتمنع
+
+144
+00:12:19,860 --> 00:12:24,100
+انتصاص الحديد طبعا موجودة زى ما انتوا شايفين كمان
+
+145
+00:12:24,100 --> 00:12:29,000
+فى التنيت اللى هو الشاي وشرب الشاي أثناء الأكل من
+
+146
+00:12:29,000 --> 00:12:34,980
+أسوأ العادات اللى نتبعها و اللى بتقلل من انتصاص
+
+147
+00:12:34,980 --> 00:12:41,540
+الحديد ال mechanism of iron absorption بتتم بهذه
+
+148
+00:12:41,540 --> 00:12:45,460
+الطريقة ناخد الأكل يدخل على الماعدة فى الماعد طبعا
+
+149
+00:12:45,460 --> 00:12:51,880
+بدخل على شكل فرقفي المعدة بيقابل pH واطية low pH
+
+150
+00:12:51,880 --> 00:12:57,900
+وفي وجود كمان reducing agent تاني في وجود vitamin
+
+151
+00:12:57,900 --> 00:13:04,340
+C او ascorbic acid بيتحول
+
+152
+00:13:04,340 --> 00:13:11,900
+الفرق إلى فرس و ثم بعد ذلك بينزل على الأمحاء وفي
+
+153
+00:13:11,900 --> 00:13:16,860
+الأمحاء ال pH مش acidic alkaline فبتحوله مرة تانية
+
+154
+00:13:17,430 --> 00:13:22,050
+الـ alkaline بيأتش إلى فرق compound طبعا بعد ذلك
+
+155
+00:13:22,050 --> 00:13:27,870
+بيصل للامهاق وفي الامهاق بتم امتصاصه على شكل فرق
+
+156
+00:13:27,870 --> 00:13:31,510
+على شكل فرق و بخش ال intestinal mycosal cell as
+
+157
+00:13:31,510 --> 00:13:38,060
+فرق compoundطيب احنا اتفقنا على انه فيه one way
+
+158
+00:13:38,060 --> 00:13:41,240
+element فى عملية امتصاص ولكن فىش عملية execution
+
+159
+00:13:41,240 --> 00:13:45,140
+وبالتالي عشان نتحكم فى كمية ال iron اللى بتخش
+
+160
+00:13:45,140 --> 00:13:51,620
+الجسم لابد من ايهاش من التحكم في ال absorption احد
+
+161
+00:13:51,620 --> 00:13:55,760
+النظريات اللى وضعت للتحكم في ال absorption نظرية
+
+162
+00:13:55,760 --> 00:13:58,760
+بيسموها mucosal block theory ايش بتقول النظرية
+
+163
+00:13:58,760 --> 00:14:03,040
+بتقول انه لما بيصل الحديد ل ال intestinal mucosa
+
+164
+00:14:03,040 --> 00:14:08,360
+بيتجمع فى ال intestinal mucosaثم بيتحسس الجسم
+
+165
+00:14:08,360 --> 00:14:15,880
+مخازن الحديد إذا المخازن فاضية بيسمح لل iron اللي
+
+166
+00:14:15,880 --> 00:14:20,300
+دخل ال intestinal mycosis أن يخش عن الجسم وإذا
+
+167
+00:14:20,300 --> 00:14:26,320
+المخازن مليانة بيضل الحديد مخزن as fair routine
+
+168
+00:14:26,320 --> 00:14:31,860
+فيهو ال intestinal mycosis يعني إيش؟ يعني هي عبارة
+
+169
+00:14:31,860 --> 00:14:37,560
+عن مبطأ .. بيثيلها ال cells في داخل الأمعاء بيثلها
+
+170
+00:14:37,560 --> 00:14:42,300
+sloughing out بعد يومين تلاتة كل يومين تلاتة
+
+171
+00:14:42,300 --> 00:14:49,320
+بتتجدد فبالتالي بتنزل مع ال .. مع ال stool أول بول
+
+172
+00:14:49,320 --> 00:14:56,280
+فإذا دلت مخزنة الحديدبينزل مع الاسطول إذا كان
+
+173
+00:14:56,280 --> 00:15:01,360
+المخازن فاضية يدخل على الجسم وبتم عملية انتصار
+
+174
+00:15:01,360 --> 00:15:09,420
+بيسموا هذه النظرية Myocosal Block Theory طيب
+
+175
+00:15:09,420 --> 00:15:13,300
+كيف ينقل الجسم واصل إلى هذه المرحلة؟ جاله ناقل ال
+
+176
+00:15:13,300 --> 00:15:17,300
+iron في الجسم هو عبارة عن بروتين اسمه Transferrin
+
+177
+00:15:17,300 --> 00:15:20,640
+وهو عبارة عن Beta Globulin واللي في العمليات تبعه
+
+178
+00:15:20,640 --> 00:15:21,460
+74000
+
+179
+00:15:30,370 --> 00:15:35,090
+بأكد الترانسفرين بيحمل الحديد على شكل فرّك
+
+180
+00:15:35,090 --> 00:15:41,470
+والايرون بعد ذلك is transported by ترانسفرين اللي
+
+181
+00:15:41,470 --> 00:15:47,910
+حامل الايرون إلى ال bone marrow بماكن تصنيع ال
+
+182
+00:15:47,910 --> 00:15:48,650
+hemoglobin
+
+183
+00:15:51,710 --> 00:15:59,250
+و هناك في خلايا الارتروبلاست على سطح ريسبتور
+
+184
+00:15:59,250 --> 00:16:05,510
+لترانسفيرن ريسبتور هذا الترانسفيرن ريسبتور بيمسك
+
+185
+00:16:05,510 --> 00:16:11,530
+بالترانسفيرن وبعدين بصير ترانسفيرن لترانسفيرن
+
+186
+00:16:12,180 --> 00:16:17,500
+رسيبتور بالـ Transferrin اللي حامل الحديد إلى داخل
+
+187
+00:16:17,500 --> 00:16:22,600
+الارتروبلاست ثم في داخل الارتروبلاست بيصير في
+
+188
+00:16:22,600 --> 00:16:28,600
+عملية removal لل iron اللي بيستغل في تصنيع الهيم
+
+189
+00:16:28,600 --> 00:16:32,520
+وبعد هيك بيصير exvagination برجع تاني الرسيبتور
+
+190
+00:16:32,520 --> 00:16:37,300
+على سطح الخلية متحمل محمول بالـ Transferrin لكن
+
+191
+00:16:37,300 --> 00:16:41,840
+المرة هذه Transferrin فاضيمحمول بترانسفرن
+
+192
+00:16:41,840 --> 00:16:44,820
+والترانسفرن في هذه الحالة أخد منه ال iron يعني
+
+193
+00:16:44,820 --> 00:16:50,500
+فاضي يسموه ابو ترانسفرن يبقى الترانسفرن الفاضي هو
+
+194
+00:16:50,500 --> 00:16:56,010
+ابو ترانسفرن المليان هو ترانسفرنطيب وصل ال
+
+195
+00:16:56,010 --> 00:16:58,530
+intestinal mycosis قلناها لو كانوا محتاجينه و
+
+196
+00:16:58,530 --> 00:17:03,150
+بنخششه على الجسم فبخش على الجسم على ال blood طبعا
+
+197
+00:17:03,150 --> 00:17:07,130
+في ال intestinal mycosis بيتحول مرة تانية لفرس و
+
+198
+00:17:07,130 --> 00:17:12,170
+بيخش على ال blood as ferrous و في ال blood في نظام
+
+199
+00:17:12,170 --> 00:17:17,610
+اسمه ferro oxidase بيحاولوا مرة تانية لفرق و as
+
+200
+00:17:17,610 --> 00:17:23,330
+ferric ال transferrin بيحمله as air as ferricيبقى
+
+201
+00:17:23,330 --> 00:17:30,610
+العملية صار فيها عملية تحويل لل iron من فرق لفرس
+
+202
+00:17:30,610 --> 00:17:37,810
+لفرق لفرس ثم بيحمل as فرق بيسمو هذه العملية double
+
+203
+00:17:37,810 --> 00:17:43,630
+redox reaction double redox يعني reduction
+
+204
+00:17:43,630 --> 00:17:51,150
+oxidation reaction طيب أشكل الحديد
+
+205
+00:17:52,130 --> 00:17:56,410
+أو مخزون الحديد قالوا فيه إنها شكلين أساسين
+
+206
+00:17:56,410 --> 00:18:02,710
+الأولاني بيسموه فرتين و هو الأساس ماشي و الفرتين
+
+207
+00:18:02,710 --> 00:18:06,770
+هو عبارة عن compound مولد للوية تبعه خمسة و اربعين
+
+208
+00:18:06,770 --> 00:18:10,810
+ألف بيتكوم من أربع و عشرين polypeptide subunits
+
+209
+00:18:10,810 --> 00:18:14,230
+مشكلة
+
+210
+00:18:14,230 --> 00:18:20,990
+على شكل halosphere يعني كرة ال diameter تبعها خمسة
+
+211
+00:18:20,990 --> 00:18:33,710
+نانومترلو فحصناها بنلاقي 25% منها Iron وزنا ووجدوا
+
+212
+00:18:33,710 --> 00:18:40,910
+أن مخزون الحديد اللي في الجسم بطولتينه عبارة عن
+
+213
+00:18:40,910 --> 00:18:45,070
+فراتين طولتينه عبارة عن إيش؟ عبارة عن فراتين يبقى
+
+214
+00:18:45,070 --> 00:18:51,390
+مخزون الحديد طولتينه على شكل فراتين و الفراتين هو
+
+215
+00:18:51,390 --> 00:18:52,130
+عبارة عن كل
+
+216
+00:18:56,170 --> 00:19:01,950
+العضلات تتجمع على شكل سفير يعني كرة ال diameter
+
+217
+00:19:01,950 --> 00:19:08,190
+تبعها خمسة نانومتر و ال iron موجود في مركزها مركز
+
+218
+00:19:08,190 --> 00:19:16,310
+هذه الكرة مركز هذه الكرة طبعا إذا كان capacity of
+
+219
+00:19:16,310 --> 00:19:21,790
+storage of iron infinity is exceeded اذا زادت
+
+220
+00:19:24,440 --> 00:19:28,900
+ببدأ يرتبط الفراتين بقضاء كمباوض زي الفوسفيت عند
+
+221
+00:19:28,900 --> 00:19:33,600
+هيدروكسايد فورم و ببدأ يتفتفت على شكل هيموسيبرين
+
+222
+00:19:33,600 --> 00:19:41,480
+اللي برضه موجود أي شكل الفراتين كرة في داخلها ال
+
+223
+00:19:41,480 --> 00:19:41,900
+iron
+
+224
+00:19:45,570 --> 00:19:50,070
+هو الـ Hemocydrine هو عبارة عن الـ amorphous form
+
+225
+00:19:50,070 --> 00:19:55,090
+of الريتين 37
+
+226
+00:19:55,090 --> 00:20:02,830
+% من وزن الحديد طبعا بشكل طول مخزون الحديد في
+
+227
+00:20:02,830 --> 00:20:07,770
+الجسم زيادته
+
+228
+00:20:07,770 --> 00:20:12,170
+خطيرة لأنه يترسب على أعضاء الجسم المختلفة ويمكن
+
+229
+00:20:12,170 --> 00:20:14,350
+يجعلها dysfunctional
+
+230
+00:20:16,080 --> 00:20:22,260
+طيب هذه علاقة رياضية من خلالها نستطيع نتعرف على
+
+231
+00:20:22,260 --> 00:20:26,940
+وجود ال iron في الجسم هل هو طبيعي ولا غير طبيعي؟
+
+232
+00:20:27,920 --> 00:20:31,740
+ماشي ايش هو ايش العلاقة هذه العلاقة بتقول ان ال
+
+233
+00:20:31,740 --> 00:20:35,840
+total iron binding capacity total iron قدرة ال
+
+234
+00:20:35,840 --> 00:20:39,260
+iron على الأرتباط بالtransfer يعني سموها total
+
+235
+00:20:39,260 --> 00:20:43,880
+iron binding capacity بساوي ال saturated يعني
+
+236
+00:20:43,880 --> 00:20:48,580
+المرتبط زائد ال unsaturated يعني غير مرتبط طبيعي
+
+237
+00:20:48,580 --> 00:20:55,200
+جدا ماشي وجدوا ان المرتبط فقط هو تلت كمية ال
+
+238
+00:20:55,200 --> 00:20:58,460
+transfer يعنيالـ Column هذا كله عبارة عن
+
+239
+00:20:58,460 --> 00:21:02,700
+Transferring تلتينه فاضي و التلت فقط هو اللي إيش
+
+240
+00:21:02,700 --> 00:21:06,320
+اللي شغال و التلت فقط هو اللي شغال هذا في الوضع
+
+241
+00:21:06,320 --> 00:21:10,920
+الطبيعي طبعا أي خلل في هذه العلاقة و هذه المعادلة
+
+242
+00:21:10,920 --> 00:21:15,600
+بيعني في حالة مرضية و من خلالها بنشخص حالات مرضية
+
+243
+00:21:15,600 --> 00:21:21,160
+مختلفة و هذا مثال حي على ذلك حي ال normal تلت
+
+244
+00:21:21,160 --> 00:21:30,870
+لومية مليان و الباقي200 فاضي لأن المجموع 300 مظبوط
+
+245
+00:21:30,870 --> 00:21:35,630
+فهذا هو الطبيعي ان التلت شغال و التلتين فاضي هذا
+
+246
+00:21:35,630 --> 00:21:39,370
+في الوضع الطبيعي يعني عندي transfer بزيادة انا
+
+247
+00:21:39,370 --> 00:21:45,190
+جاهز للارتباط بال .. بال iron لكن فقط اللي برتبط
+
+248
+00:21:45,190 --> 00:21:51,890
+هو ايش؟ هوتلت ال transferrin اللي موجود طبعا زي ما
+
+249
+00:21:51,890 --> 00:21:55,430
+قلتلكوا إذا كان المراقعة دي صار فيها خلل يصير فيه
+
+250
+00:21:55,430 --> 00:21:58,670
+إيش؟ أيه و في ال late pregnancy طبعا ال iron بيقل
+
+251
+00:21:58,670 --> 00:22:02,750
+كتير فال transferrin قدرتها على ارتباط بال iron
+
+252
+00:22:02,750 --> 00:22:07,610
+بيقل لكن بيزيد ال total iron binding capacity ماشي
+
+253
+00:22:07,610 --> 00:22:11,730
+ليش بيزيد؟ لأنه زاد ال volume وبالتالي هدا هي ها
+
+254
+00:22:11,730 --> 00:22:18,030
+هدا هي ال column زاد صار بدال 300 جديش؟ 500؟في الـ
+
+255
+00:22:18,030 --> 00:22:21,150
+iron deficiency نفس الحكاية جل ال iron كتير
+
+256
+00:22:21,150 --> 00:22:29,750
+وبالتالي يقلل ال transferrin binding capacity ال
+
+257
+00:22:29,750 --> 00:22:32,290
+.. ال .. ال transferrin اللي حامل الحديد يعني
+
+258
+00:22:32,290 --> 00:22:37,810
+saturation يعني لكن برضه في نفس الحكاية بيصير فيه
+
+259
+00:22:37,810 --> 00:22:41,830
+زيادة في total iron binding capacity في الثلاثيمية
+
+260
+00:22:41,830 --> 00:22:51,090
+ال iron بيزيادة ماشي لكن فشيبلد volume كتير ف
+
+261
+00:22:51,090 --> 00:22:54,710
+total aerobic capacity بتقل و هكذا يبقى من خلال
+
+262
+00:22:54,710 --> 00:23:00,430
+هذه المعادلة احنا بنستطيع ان نشخص حالات مرضية
+
+263
+00:23:00,430 --> 00:23:07,170
+مختلفة و هذا ال profile اللي من خلاله ممكن نعمله و
+
+264
+00:23:07,170 --> 00:23:10,430
+نشخص اللي هو different types of anemia هي ال
+
+265
+00:23:10,430 --> 00:23:14,920
+aerodeficiency chronic anemiaثلاثيميا و
+
+266
+00:23:14,920 --> 00:23:18,360
+Ancedroplastic Anemia كلها عبارة عن أنيميا بتتعلق
+
+267
+00:23:18,360 --> 00:23:24,460
+بالحديد و هي الفحوصات ICBC الـ Iron Total Iron
+
+268
+00:23:24,460 --> 00:23:28,060
+Bending Capacity Transferrin Saturation اللي هو
+
+269
+00:23:28,060 --> 00:23:33,820
+نسبة تشبع الترانسفيرن بالحديد ثم Serum Ferritin ثم
+
+270
+00:23:33,820 --> 00:23:37,760
+Serum Transferrin Receptor ثم ال Bonmarin Iron
+
+271
+00:23:37,760 --> 00:23:40,180
+Store و ال Erythroplast
+
+272
+00:23:43,910 --> 00:23:48,030
+سيرام الـ Transferrin Receptor ببساطة يا بنات و يا
+
+273
+00:23:48,030 --> 00:23:51,610
+شباب هو عبارة عن الـ Receptor اللي بيحمل الـ
+
+274
+00:23:51,610 --> 00:23:56,730
+Transferrin اللي ماسك الحديد طيب إذا كان .. احنا
+
+275
+00:23:56,730 --> 00:23:59,430
+بنقول سيرام، وين موجود هذا؟ موجود على الارثروبلاست
+
+276
+00:23:59,430 --> 00:24:02,750
+طب إيش دخل السيرام في الموضوع؟ قالوا اليوم يكون
+
+277
+00:24:02,750 --> 00:24:08,730
+الـ Iron قليل بيكون
+
+278
+00:24:08,730 --> 00:24:14,840
+الـ Transferrin هذا الـ Receptor لا يشغليكون
+
+279
+00:24:14,840 --> 00:24:18,240
+استخدامه قليل وإذا لم يستغل ال Transferring
+
+280
+00:24:18,240 --> 00:24:23,640
+Receptor يصبح له Truncation يخلع من الاربيز من ال
+
+281
+00:24:23,640 --> 00:24:28,000
+الاثرويد سيل ويصبح له إطلاق في البلازمة أو في
+
+282
+00:24:28,000 --> 00:24:32,800
+السيرام فيوم ما نشوفه عالي في السيرام أو البلازمة
+
+283
+00:24:32,800 --> 00:24:40,550
+ال Receptor بيكون فيه Iron Deficiencyأو بيكون فيه
+
+284
+00:24:40,550 --> 00:24:44,030
+Anemia أو Microdisorder، دلوقت هنحكي عليها لكن في
+
+285
+00:24:44,030 --> 00:24:50,230
+حالة وجود اللي هو النقص في الحديد برضو أو في مخزون
+
+286
+00:24:50,230 --> 00:24:56,210
+الحديد عشان هي كفي كثير من المعامل عملية التفريق
+
+287
+00:24:56,210 --> 00:24:59,670
+ما بين ال Anemia أرض في شنسي أنيميا و Anemia
+
+288
+00:24:59,670 --> 00:25:04,510
+Microdisorder بتتم من خلال هذا ال marker وهو Serum
+
+289
+00:25:04,510 --> 00:25:06,490
+Transferrin Receptor
+
+290
+00:25:09,800 --> 00:25:15,360
+و نبدأ الأن نشوف أمثلة على ال iron metabolism
+
+291
+00:25:15,360 --> 00:25:20,120
+disorder و زي ما قلتلكوا أشهر هذه الحالات هي iron
+
+292
+00:25:20,120 --> 00:25:27,160
+deficiency anemia بتم فيها نقص في ال iron
+
+293
+00:25:27,160 --> 00:25:34,700
+concentration أقل من الطبيعي و شوي شوي بزيد النقص
+
+294
+00:25:34,700 --> 00:25:35,800
+إلى أنص
+
+295
+00:25:43,690 --> 00:25:46,390
+Iron Deficiency Anemia وبالتالي Iron Deficiency
+
+296
+00:25:46,390 --> 00:25:51,670
+Anemia هي عبارة عن مراحل أخر مرحلة هي التي تظهر
+
+297
+00:25:51,670 --> 00:25:57,090
+فيها symptoms بغضوح و بيسموها Iron Deficiency
+
+298
+00:25:57,090 --> 00:26:01,710
+Anemia ما هي المراحل تاعة Iron Deficiency Anemia؟
+
+299
+00:26:01,710 --> 00:26:05,230
+يقولوا نمرا واحد Negative Iron Balance ماشي يعني
+
+300
+00:26:05,230 --> 00:26:09,750
+Negative Iron Balance؟ يعني والله كمية الحديده
+
+301
+00:26:09,750 --> 00:26:15,530
+التي تمتص من برا تتاخد من برافببدأ الإنسان ياخد
+
+302
+00:26:15,530 --> 00:26:20,330
+إياش من المخزون ببدأ الإنسان ياخد من إياش من
+
+303
+00:26:20,330 --> 00:26:24,990
+المخزون نمرة اتنين latent iron deficiency إذا
+
+304
+00:26:24,990 --> 00:26:30,230
+استمرت الحكاية زيادة عن اللزوم بتفضل مخازنه لكن
+
+305
+00:26:30,230 --> 00:26:35,130
+لازال فيه normal hemopoiesis كمية الحديد اللي
+
+306
+00:26:35,130 --> 00:26:42,810
+بتتاخد من المرة بتكفي لعمل لتصنيع خلايانمر تلاتة
+
+307
+00:26:42,810 --> 00:26:47,770
+إذا تطورت أكتر نصل لمرحلة بتفضل مخازن وما بتكفل
+
+308
+00:26:47,770 --> 00:26:53,250
+كمية اللي بتتاخد من برا فبالتالي بيشير في حالة
+
+309
+00:26:53,250 --> 00:26:56,410
+بيسموها iron deficient erythropoiesis خلل في
+
+310
+00:26:56,410 --> 00:27:01,310
+الاريثروبييسيس طبعا في مرحلة متقدمة جدا بعد ذلك
+
+311
+00:27:01,310 --> 00:27:04,790
+إذا استمرت بيشير في iron deficient cyanemia
+
+312
+00:27:04,790 --> 00:27:10,810
+وبالتالي البولمار بيكون يعني متأثر تأثرا كبيرا
+
+313
+00:27:13,040 --> 00:27:16,260
+أسباب الـ iron deficiency أنينيا كانوا يبروحها
+
+314
+00:27:16,260 --> 00:27:21,000
+decrease supply of iron يعني فاش ايران بيخش الجسم
+
+315
+00:27:21,000 --> 00:27:25,660
+or increase requirement of our iron يعني في زيادة
+
+316
+00:27:25,660 --> 00:27:30,480
+في الطلب عليه احتياجاتنا أكتر ونبدأ بأول سبب وهو
+
+317
+00:27:30,480 --> 00:27:34,600
+decrease supply of iron كانوا بتندرج عن تحتي
+
+318
+00:27:35,390 --> 00:27:40,030
+الأسباب الاتيانية إنها adequate diet بمعنى إنه
+
+319
+00:27:40,030 --> 00:27:44,070
+والله مافيش حديد في الأكل اللي بناخده وده كلام
+
+320
+00:27:44,070 --> 00:27:48,590
+بينطبقش على الأكل الشرقي لإنه في الأكل الشرقي في
+
+321
+00:27:48,590 --> 00:27:53,930
+حديد بكميات كبيرة توصل ل 18 milligram من ال iron
+
+322
+00:27:53,930 --> 00:28:00,210
+احنا فقط بناخد منها من خمسة لعشر أفلمية سبب تاني
+
+323
+00:28:00,210 --> 00:28:04,740
+which is common usuallyوهو مال absorption of
+
+324
+00:28:04,740 --> 00:28:09,900
+dietary iron مال absorption of dietary iron طيب،
+
+325
+00:28:09,900 --> 00:28:11,920
+شو اللي بيصير؟ قالوا اللي مافي خلل في absorption.
+
+326
+00:28:12,240 --> 00:28:15,680
+إيش الدعوة؟ قالوا في خلل في مواقع انتصاص الحديد.
+
+327
+00:28:16,080 --> 00:28:18,580
+طب وين بيمتص الحديد؟ قالوا في الأبر، elementary
+
+328
+00:28:18,580 --> 00:28:22,960
+tract, dodenal والأبرجيجنال، يكون في خلل في
+
+329
+00:28:22,960 --> 00:28:29,320
+الأمهات وبالتالي بيصير في خلل في الانتصاص.من أشهر
+
+330
+00:28:29,320 --> 00:28:32,880
+الأمراض اللي بتعمل هذا الخلل هو celiac disease عدم
+
+331
+00:28:32,880 --> 00:28:36,880
+امتصاد طبعا celiac disease اللي هو بيصير فيهاش عدم
+
+332
+00:28:36,880 --> 00:28:40,340
+امتصاد لكميات كبيرة من ال minerals و ال .. و ال
+
+333
+00:28:40,340 --> 00:28:45,940
+atoms السبب في ذلك انه مافيهاش في اللي هو أتروفي
+
+334
+00:28:45,940 --> 00:28:52,860
+للcelia شو اللي بيصير؟ بيصير عدم امتصاد طب في
+
+335
+00:28:52,860 --> 00:28:56,820
+حالات أخرى برضه بيصير فيه عدم امتصاد جاله نعميوم
+
+336
+00:28:56,820 --> 00:29:00,640
+يكون في partial gastrectomy واحد صار عنده خلل في
+
+337
+00:29:00,640 --> 00:29:05,480
+ال .. في ال .. في ال stomach و شلوله جزء منها
+
+338
+00:29:05,480 --> 00:29:12,040
+بيسموها gastrectomy partial gastrectomy او استخدام
+
+339
+00:29:12,040 --> 00:29:16,320
+ال antacid انجش الناس كتير تحصل معاهم حموضة فبياخد
+
+340
+00:29:16,320 --> 00:29:21,020
+كميات كبيرة من ال antacid هذي ايضا تمنع الانتصاص
+
+341
+00:29:21,020 --> 00:29:26,330
+الحديد لإن أوللقاء بين الحديد و بين .. في الجسم هو
+
+342
+00:29:26,330 --> 00:29:37,470
+ال stomach و ان ال acid medium is important السبب
+
+343
+00:29:37,470 --> 00:29:41,290
+التاني لل iron deficiency هو increase requirement
+
+344
+00:29:41,290 --> 00:29:47,390
+for iron و يتدرج تحته تلت أسباب أساسية هو ال blood
+
+345
+00:29:47,390 --> 00:29:53,890
+loss طبعا يوم يفقد الدم للإنسانثم growth and
+
+346
+00:29:53,890 --> 00:29:58,430
+pregnancy and loss of iron ونشوف وقت إيش بيصير فيه
+
+347
+00:29:58,430 --> 00:30:01,790
+blood loss لأنه من أشهر الأسباب اللي بيصير فيها
+
+348
+00:30:01,790 --> 00:30:05,750
+فقدر على الدم menstruation طبعا دورة شهرية
+
+349
+00:30:05,750 --> 00:30:13,210
+parasitic infection ناس بيكون عندهم infestation by
+
+350
+00:30:13,210 --> 00:30:19,230
+angostoma and nicator americanus هدول عبارة عن
+
+351
+00:30:27,850 --> 00:30:33,610
+Carcinoma Tudinal ulcer قرحة في الاثنين عشر
+
+352
+00:30:33,610 --> 00:30:42,550
+هيتاسيرمية اللي هو افتاج السرعة Homeroid و
+
+353
+00:30:42,550 --> 00:30:46,570
+Minorrhagia ال homeroid اللي هو البواصير و ال
+
+354
+00:30:46,570 --> 00:30:50,390
+minorrhagia اللي هي excessive menses
+
+355
+00:30:53,300 --> 00:30:55,780
+هذا أول سبب السبب التاني growth and pregnancy
+
+356
+00:30:55,780 --> 00:31:01,820
+تفقناه بشكل طبيعي أثناء البلوغ أثناء المراهقة طبعا
+
+357
+00:31:01,820 --> 00:31:06,880
+بستيد اللي هو فترة نمو الإنسان يحتاج لحديد أكتر
+
+358
+00:31:06,880 --> 00:31:14,510
+أيضا في حالات ال pregnancyففي ال pregnancy ال
+
+359
+00:31:14,510 --> 00:31:18,630
+female بتتعرض ل 3 challenges تلت تحديات مختلفة
+
+360
+00:31:18,630 --> 00:31:22,770
+التحدي الأولاني أنه بزيد حجم ال blood volume عندها
+
+361
+00:31:22,770 --> 00:31:28,470
+بحوالي 20 ل 40% وهذا بيترتب عليه زيادة في امتصاص
+
+362
+00:31:28,470 --> 00:31:35,710
+الحديد بنسبة 500 milligram نمرة
+
+363
+00:31:35,710 --> 00:31:37,150
+2 ده development fetus
+
+364
+00:31:42,650 --> 00:31:46,150
+يبقى احنا فقدنا في زيادة حجم الدم 500 مليغرام
+
+365
+00:31:46,150 --> 00:31:51,790
+فقدنا فيه الجنين أخد 300 وعند الولادة ال female
+
+366
+00:31:51,790 --> 00:31:59,070
+بتفقد حوالي 500 ملي من ال blood فيهم 250 ملي من
+
+367
+00:31:59,070 --> 00:32:03,600
+ملي جرام من ال ironفالمجموع بيطلع حوالي 1500 ..
+
+368
+00:32:03,600 --> 00:32:11,640
+1050 يعني جرام و خمسين ملي جرام من ال iron بيفقد
+
+369
+00:32:11,640 --> 00:32:14,660
+الشيء الوحيد الإيجابي في الموضوع أنه في ال
+
+370
+00:32:14,660 --> 00:32:18,520
+pregnancy مافيش من ال menstruation فده بتعوض
+
+371
+00:32:18,520 --> 00:32:23,400
+الفيميل بحوالي 200 ملي جرام من ال iron بس يعني في
+
+372
+00:32:23,400 --> 00:32:29,090
+جميع الأحوال اللي بيضل حوالي 850 ملي جرام فاقد850
+
+373
+00:32:29,090 --> 00:32:33,710
+ملي جرام يعني احنا تقريبا تلت مخزونة او تلت الحديد
+
+374
+00:32:33,710 --> 00:32:40,670
+اللي في جسمها كله بكلبرجنانسي بيستهلك loss of iron
+
+375
+00:32:40,670 --> 00:32:43,870
+اكثر من كثير ممكن يصير فيه عملية loss of iron
+
+376
+00:32:43,870 --> 00:32:49,150
+during intravascular hemolysis وطبعا كمية كبيرة من
+
+377
+00:32:49,150 --> 00:32:54,870
+ال iron as hemocedrine يفقد في الورينوطيب،
+
+378
+00:32:54,870 --> 00:32:57,750
+الانعكاسات هذه تأثيرها ال pathophysiology، الألية
+
+379
+00:32:57,750 --> 00:33:01,210
+المرضية، إيش اللي بنصير؟ قالوا والله ال iron
+
+380
+00:33:01,210 --> 00:33:06,590
+deficiency عينيميا غالبا بتكون مسحوبة ب clinical
+
+381
+00:33:06,590 --> 00:33:11,030
+manifestation، two clinical manifestation إيش؟ هم
+
+382
+00:33:11,030 --> 00:33:16,330
+قالوا يوم ما اتأثر على ال blood و ال blood forming
+
+383
+00:33:16,330 --> 00:33:21,750
+tissueو حاجة تانية بتأثر على ال other tissue و
+
+384
+00:33:21,750 --> 00:33:26,010
+هنشوف إيش تأثيراتها على كل من هنا تأثير الأولاني
+
+385
+00:33:26,010 --> 00:33:30,270
+على blood و blood forming tissue طبعا يوم يقل ال
+
+386
+00:33:30,270 --> 00:33:36,690
+iron يقل تصنيع ال hemoglobin ماشي و هذا يعني عكس
+
+387
+00:33:36,690 --> 00:33:43,490
+كالأياتي نمر واحد يقل ال hemoglobin و في الخلية
+
+388
+00:33:43,490 --> 00:33:48,810
+طبعا و هذا بنشوفه بوضوحيوم ما يكون الـ MCHC برضه
+
+389
+00:33:48,810 --> 00:33:56,490
+واطية بزيد الـ preprotoporphin تركيزه في الخلية
+
+390
+00:33:56,490 --> 00:34:02,490
+والـ protoporphin هو عبارة عن المادة التي تسبق أو
+
+391
+00:34:02,490 --> 00:34:09,010
+المركبة اللذي يسبق الهيم في تكوينه فبالتالي يوم ما
+
+392
+00:34:09,010 --> 00:34:14,270
+يكون مافيش حديد يبقى مافيش هيمSynthesis فشو بيضل
+
+393
+00:34:14,270 --> 00:34:22,730
+المركب اللي بيتراكم اللي هو ال Protoporphine لإنه
+
+394
+00:34:22,730 --> 00:34:28,610
+ما بيتحول إلى الهيم في تصنيع ال hemoglobin طبعا
+
+395
+00:34:28,610 --> 00:34:34,970
+شواء شوية ال RBCs بتصير microcytic hypochromic و
+
+396
+00:34:34,970 --> 00:34:38,190
+microcytosis لإنه بتقعد في ال bone marrow فترة
+
+397
+00:34:38,190 --> 00:34:43,700
+أكبر تستنىيعني حصولها على الـ Iron وبالتالي طول ما
+
+398
+00:34:43,700 --> 00:34:47,520
+هي جاعدة في البرمرو وطول ما هي بتنقسم الخلية
+
+399
+00:34:47,520 --> 00:34:52,540
+فبتصغر عشان هيك ال anemia of iron deficiency هي
+
+400
+00:34:52,540 --> 00:34:56,980
+عبارة عن microcytic hypochromic anemia بس يكون
+
+401
+00:34:56,980 --> 00:35:00,920
+فيها reticulocytopenia طبعا مافيش إنتاج للحديد
+
+402
+00:35:00,920 --> 00:35:05,480
+مافيش .. مافيش امتصاص للحديد مافيش إنتاج لل
+
+403
+00:35:05,480 --> 00:35:10,470
+hemoglobinالتي تسمى Erythropoiesis is defected
+
+404
+00:35:10,470 --> 00:35:17,730
+وبالتالي معامل إنتاج ال bone marrow يعني ال RBCs
+
+405
+00:35:17,730 --> 00:35:23,090
+بيتمثل بوجود ال reticulocyte لأنه قلنا بتنزل على
+
+406
+00:35:23,090 --> 00:35:26,010
+ال peripheral blood ال reticulocyte جاب اليوم من
+
+407
+00:35:26,010 --> 00:35:32,410
+تحولها إلى ال mature تقعد يوم فهي indicator وجودها
+
+408
+00:35:32,410 --> 00:35:34,910
+indicator في ال peripheral blood على إنه في إنتاج
+
+409
+00:35:34,910 --> 00:35:40,030
+لل bone marrow عشان هيك بيسموها معاملBone marrow
+
+410
+00:35:40,030 --> 00:35:43,950
+production index طيب لو مافيش reticulocyte مافيش
+
+411
+00:35:43,950 --> 00:35:47,910
+انتاج عشان هي كان في ال iron deficiency يعني ما
+
+412
+00:35:47,910 --> 00:35:54,770
+مافي انتاج فبالتالي في reticulocyte فيه الاشي
+
+413
+00:35:54,770 --> 00:36:00,730
+التاني اللي او الرابع اللي ممكن نشوفه انه نفحص ال
+
+414
+00:36:00,730 --> 00:36:02,990
+bone marrow و في ال bone marrow بنلاقي
+
+415
+00:36:06,360 --> 00:36:11,320
+هيبو بليجيا يعني مافي عملية تصنيع لل إيراثرويد
+
+416
+00:36:11,320 --> 00:36:18,400
+precursor cell هيبو قلة بليجيا تصنيع وتكوين ماشي
+
+417
+00:36:18,400 --> 00:36:25,660
+وبالتالي مافي كمان لو فحصنا ال iron في مخازن ال
+
+418
+00:36:25,660 --> 00:36:26,680
+bomber اللي هي ال macro
+
+419
+00:36:30,990 --> 00:36:37,130
+وبالتالي الـ cytoplasm تبع ال macrophage .. تبع ال
+
+420
+00:36:37,130 --> 00:36:41,050
+normoplast هو عبارة عن cytoplasm منقطة ragged يعني
+
+421
+00:36:41,050 --> 00:36:45,010
+منقطة ليش منقطة؟ قالوا نسبة النطفة اللي بيصير فيها
+
+422
+00:36:45,010 --> 00:36:50,590
+تصنيع hemoglobin تتلون و اللي ما بيصير ما بتتلون
+
+423
+00:36:50,590 --> 00:36:55,090
+فبالتالي بنلاقي cytoplasm جزء منه ملون و جزء منه
+
+424
+00:36:55,090 --> 00:36:57,230
+مش ملون عشان هيك بنلاقيه منقطة
+
+425
+00:37:00,060 --> 00:37:04,940
+يبجى عشان انا اعمل اللي هو اشخص Aerodeficiency
+
+426
+00:37:04,940 --> 00:37:09,280
+Anemia بدي اعمل القادي بعد دي اعمل CBC واشوف قلة
+
+427
+00:37:09,280 --> 00:37:14,360
+ال hemoglobin و ال blood index ثم بدي افحص ال
+
+428
+00:37:14,360 --> 00:37:19,180
+protocol ثم بدي اعمل blood film واشوف microcytic
+
+429
+00:37:19,180 --> 00:37:23,460
+hypochromic anemia ثم بدي اشوف ال reticulocytes
+
+430
+00:37:29,540 --> 00:37:32,880
+طب هذا بالنسبة لإيش لل hematological analyst طب و
+
+431
+00:37:32,880 --> 00:37:35,560
+بالنسبة لل chemistry قالوا ال chemistry بتعمل
+
+432
+00:37:35,560 --> 00:37:39,100
+biochemical reaction أو biochemical profile test
+
+433
+00:37:40,290 --> 00:37:45,370
+ماشي لمين لل iron فبتفحص ال iron و مخزون ال iron
+
+434
+00:37:45,370 --> 00:37:49,410
+اللي هو الفرتين و ال total iron binding capacity و
+
+435
+00:37:49,410 --> 00:37:53,770
+ال percent of saturation لل transferrin و بتشوف ال
+
+436
+00:37:53,770 --> 00:37:59,570
+serum transferrin receptors كل هذه عوامل ممكن
+
+437
+00:37:59,570 --> 00:38:01,690
+تفحصها و تشوفها
+
+438
+00:38:04,220 --> 00:38:09,420
+ال figure هذا مبين ليه اللي هو التطور اللي بتمر في
+
+439
+00:38:09,420 --> 00:38:14,660
+خلية ال RBCs في وجود iron deficiency بتبدأ ب
+
+440
+00:38:14,660 --> 00:38:21,080
+normal و بتنتهي ب microcytic hypochromic anemia و
+
+441
+00:38:21,080 --> 00:38:24,240
+هذا عبارة عن profile ممكن نعمله في حالة ال iron
+
+442
+00:38:24,240 --> 00:38:29,200
+deficiency أنيميا وهي اللي نتعيش طيب هذا بالنسبة
+
+443
+00:38:29,200 --> 00:38:32,080
+لتأثيره على ال blood blood forming unit طب تأثيره
+
+444
+00:38:32,080 --> 00:38:32,520
+على other
+
+445
+00:38:36,080 --> 00:38:40,020
+التيشو ياله بيأثر على ال rapidly dividing cell
+
+446
+00:38:40,020 --> 00:38:43,120
+اللى هى ال epithelial cells اللى دايما بتتجدد
+
+447
+00:38:43,120 --> 00:38:48,920
+فبيأثر على بيعمل coelynesia ودى عبارة عن spoon
+
+448
+00:38:48,920 --> 00:38:56,020
+nail of the finger ماشى يعني ايه القدفر بياخد شكل
+
+449
+00:38:56,020 --> 00:38:57,900
+يتقهر
+
+450
+00:39:00,830 --> 00:39:05,030
+بسموها coil anesia ثم angular stomatitis بتلاقي
+
+451
+00:39:05,030 --> 00:39:12,950
+طرفي الفم صار فيهم atrophy ثم aglossitis بتلاقي
+
+452
+00:39:12,950 --> 00:39:18,570
+الإجسام صار فيه smooth and flamed tongue ثم
+
+453
+00:39:18,570 --> 00:39:22,990
+atrophic gastritis بيصير فيه inflammation of the
+
+454
+00:39:22,990 --> 00:39:29,670
+lining of the stomach ثم achlorohydra يعني مافيش
+
+455
+00:39:30,670 --> 00:39:35,590
+Hydrochloric acid في ال .. في ال stomach ثم Pika
+
+456
+00:39:35,590 --> 00:39:39,130
+Pika هي عبارة عن غاهرة لجوا ان الناس اللي عندهم
+
+457
+00:39:39,130 --> 00:39:43,710
+iron deficiency عندهم تصرفات غريبة انهم ممكن
+
+458
+00:39:43,710 --> 00:39:51,610
+ياكلوااللي هو المواد المثلجة اللي هي ال ice زي ال
+
+459
+00:39:51,610 --> 00:39:54,850
+.. ال .. ال .. ال .. بيسموها pediophagia أو ال
+
+460
+00:39:54,850 --> 00:39:58,750
+soil geophagia ممكن ياكلوا عاجزة غريبة زي الصوفي
+
+461
+00:39:58,750 --> 00:40:05,210
+ناتشو زي الرمل ينبلع و هكذا هذه ال coil anemia
+
+462
+00:40:05,210 --> 00:40:09,850
+المرض
+
+463
+00:40:09,850 --> 00:40:12,550
+التاني اللي بتعلق بال iron هو ال anemia و ال
+
+464
+00:40:12,550 --> 00:40:16,360
+chronic disordersوالانيميا و ال chronic disorders
+
+465
+00:40:16,360 --> 00:40:23,160
+من الإسم أنيميا ناتجة عن chronic disease يعني إذا
+
+466
+00:40:23,160 --> 00:40:28,120
+كان chronic inflammation أو ماليجنانسي و عادة
+
+467
+00:40:28,120 --> 00:40:31,220
+usually هي normocytic و normochronic لكن بتصير
+
+468
+00:40:31,220 --> 00:40:36,400
+برضه hypocytic .. hypochromic microcytic
+
+469
+00:40:36,400 --> 00:40:43,350
+hypochromic sorryand طبعا هذه لا يشفى الإنسان منها
+
+470
+00:40:43,350 --> 00:40:48,470
+إلا بشفاء السبب الأساسي ال primary cause قلية
+
+471
+00:40:48,470 --> 00:40:53,530
+المرض pathophysiology يعني هو بيصير في القاهة نمر
+
+472
+00:40:53,530 --> 00:40:56,570
+واحد في chronic inflammation ال inflammatory
+
+473
+00:40:56,570 --> 00:41:05,020
+process usually بتكون مصحوبة بميكانزمات منعيةفأول
+
+474
+00:41:05,020 --> 00:41:08,760
+هذه الأشياء أو الخلايا المنعية المتأثرة في هذا
+
+475
+00:41:08,760 --> 00:41:12,300
+الموضوع ال macro phage قالوا يوم السويس كون فيه
+
+476
+00:41:12,300 --> 00:41:17,820
+chronic inflammation ال macro phage بتزود ال
+
+477
+00:41:17,820 --> 00:41:22,220
+abutransfer receptor على سطحها شو بده يعمل هذا ال
+
+478
+00:41:22,220 --> 00:41:26,540
+receptor بيروحوا ملجة ال transferrin وإذا كان قل
+
+479
+00:41:26,540 --> 00:41:29,640
+ال transferrin بده يقل ال total iron binding
+
+480
+00:41:29,640 --> 00:41:34,210
+capacityالحاجة التانية كمان في ال inflammation
+
+481
+00:41:34,210 --> 00:41:38,190
+تتنشط ال neutrophil وتروح يصنع كميات كبيرة من
+
+482
+00:41:38,190 --> 00:41:44,590
+الابولاكتوفرين و بتفرزها والابولاكتوفرين اللي هو
+
+483
+00:41:44,590 --> 00:41:48,230
+ال receptor على سطح الماكروفيج فبروح و جاعد على
+
+484
+00:41:48,230 --> 00:41:52,330
+الابولاكتو .. على سطح الماكروفيج و الماكروفيج وهي
+
+485
+00:41:52,330 --> 00:41:56,030
+ماشية .. شو بتعمل بالابولاكتوفرين؟ الاكتروفين ده
+
+486
+00:41:56,030 --> 00:41:59,170
+وظيفته الأساسية عملية طلقية ال iron برتبط بال iron
+
+487
+00:42:00,630 --> 00:42:05,110
+فبروحوا ملقّة الـ iron وكأنه مغناطيس ملقّة ال iron
+
+488
+00:42:05,110 --> 00:42:10,990
+الموجود فيه ال blood فصار ال iron مرتبط بالـ
+
+489
+00:42:10,990 --> 00:42:14,090
+receptor على سطح ال macro phage ثم بيصله
+
+490
+00:42:14,090 --> 00:42:18,370
+internalization بيخزن في داخل ال macro phage as
+
+491
+00:42:18,370 --> 00:42:25,510
+فرتين فالفرتين بيزيد يبقى ال iron قلوالفراتين زاد
+
+492
+00:42:25,510 --> 00:42:30,390
+و ال ايرو نقاش قل و الفراتين زاد و الدعم اول
+
+493
+00:42:30,390 --> 00:42:35,770
+اعرفنا ان ال total aerobatic capacity قلت طب مش
+
+494
+00:42:35,770 --> 00:42:39,550
+فيه كمان بيشير قالوا الارتروبيوتك activity is
+
+495
+00:42:39,550 --> 00:42:46,050
+suppressed يعني بكل الإمتاز مش طب ليش؟Cytokine
+
+496
+00:42:46,050 --> 00:42:49,930
+release يوم ما تتنشط هذه الخلايا المناعية بتفرز IL
+
+497
+00:42:49,930 --> 00:42:54,230
+-1 وبتفرز Gamma Interferon وTumor Necrosis Factor
+
+498
+00:42:54,230 --> 00:42:58,550
+وهذه عبارة عن Inhibitory Cytokine شو بتعمل؟ بتعمل
+
+499
+00:42:58,550 --> 00:43:02,790
+Inhibition لل Erythropoiesis طب وإيش بالتالي؟
+
+500
+00:43:02,790 --> 00:43:06,750
+بالتالي بيقلل ال Erythropoietic Activity طيب هي
+
+501
+00:43:06,750 --> 00:43:10,590
+قلت ال Erythropoietic Activity قالوا كمان بتقل ال
+
+502
+00:43:10,590 --> 00:43:14,940
+life span تبع ال herpesيعني كله بيقل و بتتاري
+
+503
+00:43:14,940 --> 00:43:20,260
+المحصة لأنيميا طب كيف بنشخص؟ قالوا الانيميا هي
+
+504
+00:43:20,260 --> 00:43:24,660
+أبقى mainly normocytic لكنها eventually microcytic
+
+505
+00:43:24,660 --> 00:43:28,540
+بعض المرات بتصير microcytic السبب inflammatory
+
+506
+00:43:28,540 --> 00:43:33,020
+disease أو cancer شو بيصير؟ قالوا بيصير في low
+
+507
+00:43:33,020 --> 00:43:39,400
+iron concentration وهذا كله بيتوافق مع الانيميا
+
+508
+00:43:39,400 --> 00:43:44,360
+iron deficiency anemiaلكن بنلاحظ أنه في اختلافات
+
+509
+00:43:44,360 --> 00:43:49,080
+بدت تظهر على الخط زي الفررتين بزيد و ال transferin
+
+510
+00:43:49,080 --> 00:43:53,820
+بقلب و ال iron store بصفشا بمعنى normal or
+
+511
+00:43:53,820 --> 00:43:57,780
+increased و هذه كلها بتختلف عن ايش عن iron
+
+512
+00:43:57,780 --> 00:44:01,540
+deficiency أنيميا و ده الجدول مبين للاختلافات ما
+
+513
+00:44:01,540 --> 00:44:05,540
+بين الانيميا و ال micro disorder ال ACD و ما بين
+
+514
+00:44:05,540 --> 00:44:10,840
+الفرق او ال iron deficiency أنيميا ماشي اخر واحد
+
+515
+00:44:10,840 --> 00:44:11,180
+اللي هو ال
+
+516
+00:44:14,320 --> 00:44:19,420
+برضه بيبقى احد ال marker اليوم مستخدم في التشخيص
+
+517
+00:44:19,420 --> 00:44:23,060
+والتفريق بينهم في ال ACD بيلاقي عالي في الانيميا
+
+518
+00:44:23,060 --> 00:44:29,520
+ايرن دفاشنسيا انيميا بيلاقي واطي سيدرو
+
+519
+00:44:29,520 --> 00:44:33,680
+بلاستيك انيميا من الاسم هي عبارة عن heterogeneous
+
+520
+00:44:33,680 --> 00:44:39,320
+group of disorders بتتميز بوجود خلل في ال
+
+521
+00:44:39,320 --> 00:44:43,900
+incorporation of iron within the brainيعني في خلال
+
+522
+00:44:43,900 --> 00:44:48,820
+في دخول ال iron في ال .. لتكوين ايه؟ لتكوين ايش؟
+
+523
+00:44:48,820 --> 00:44:53,300
+لتكوين هيم؟ احنا قلنا المركب اللي جاب للهيم هو ال
+
+524
+00:44:53,300 --> 00:44:57,580
+proto porphyrin اخر خطوة انه بيضل على ال iron و
+
+525
+00:44:57,580 --> 00:45:01,420
+نخش في ال proto porphyrin فبتحول لهيم طب في خلال
+
+526
+00:45:01,420 --> 00:45:04,760
+في هذه الخطوة يبقى فيه heme synthesis في الشيم
+
+527
+00:45:04,760 --> 00:45:13,120
+ماشي ففي proto porphyrin بزيدوببدأ الـ iron في هذه
+
+528
+00:45:13,120 --> 00:45:20,880
+الحالة مدام موجود لكنه لا في خلل في دخوله لتصنيع
+
+529
+00:45:20,880 --> 00:45:25,700
+ال heme وبالتالي بيبدأ يتجمع ال iron في
+
+530
+00:45:25,700 --> 00:45:33,280
+الميتوكندريةوتجمعوا في داخل ال RBC سوري وبالتالي
+
+531
+00:45:33,280 --> 00:45:36,260
+بيتجمع حوالين ال mitochondria، encircling the
+
+532
+00:45:36,260 --> 00:45:40,120
+mitochondria وبيعمل حاجة بسموها Ringed Sidroblast،
+
+533
+00:45:40,120 --> 00:45:44,400
+شو بسموها؟ Ringed يعني دائرة، Sidroblast، الخلية
+
+534
+00:45:44,400 --> 00:45:52,110
+صار فيها Ironوهذا مدام اتحول او تحلق حوالين الـ
+
+535
+00:45:52,110 --> 00:45:55,430
+mitochondria بيعمل حاجة بتصير ال RBC's غير طبيعية
+
+536
+00:45:55,430 --> 00:45:59,230
+فبتموت فبيعمل حاجة باسمها ineffective arthroposis
+
+537
+00:45:59,230 --> 00:46:04,150
+لكن هذه الظاهرة اللي هي ringed syndroblast بنشوفها
+
+538
+00:46:04,150 --> 00:46:09,290
+في حالة أنيمية تانية مش بس في حالة syndroblastic
+
+539
+00:46:09,290 --> 00:46:15,590
+anemia طيب قسموها إلى القادي hereditary type
+
+540
+00:46:21,200 --> 00:46:27,580
+الخلايا اللي بيترسب فيها الحديد لأنه لم يستغل ما
+
+541
+00:46:27,580 --> 00:46:31,560
+استغلنهوش في تصنيع الهيم فبدأ يترسب على الخلايا
+
+542
+00:46:31,560 --> 00:46:35,560
+ماشي و هذه عبارة عن الخلايا اللي ممكن احنا نشوفها
+
+543
+00:46:35,560 --> 00:46:41,240
+ببساطة في blood film مسبوخ ب iron stain ايش ال
+
+544
+00:46:41,240 --> 00:46:42,960
+iron stain شهير؟
+
+545
+00:46:49,370 --> 00:46:52,530
+طيب ايش ال Sidrocite و Sidroblast مصطلحات جديدة
+
+546
+00:46:52,530 --> 00:46:54,710
+يعني لأن ال Sidrocite هي عبارة عن mature
+
+547
+00:46:54,710 --> 00:46:57,690
+herbaceous لكن فيها واحد او اكتر من واحد من ال
+
+548
+00:46:57,690 --> 00:47:03,010
+Sidrotic granules او بيسموه Papenhymer normal
+
+549
+00:47:03,010 --> 00:47:06,410
+Sidroblast
+
+550
+00:47:06,410 --> 00:47:13,270
+nucleated red blood cell تحتوي على واحد او اكتر من
+
+551
+00:47:13,270 --> 00:47:21,910
+Sidrotic granules usually difficult to seeوانتشرت
+
+552
+00:47:21,910 --> 00:47:26,890
+بشكل محدد في الـ cytoplasm وغالباً
+
+553
+00:47:26,890 --> 00:47:32,410
+بنشوفها .. بنشوفها اشبتنعدم يعني في حالات الـ iron
+
+554
+00:47:32,410 --> 00:47:37,130
+deficiency أنيميا او في حالة ال chronic disorders
+
+555
+00:47:37,130 --> 00:47:45,330
+لكن ال abnormal Sidroblast بيكون فيه ايرون كتير
+
+556
+00:47:45,330 --> 00:47:50,470
+فبصير في ال رتين iron depositionوفر تنقيق
+
+557
+00:47:50,470 --> 00:47:56,830
+aggregates فبزيد ال granules ماشي و بتصير ال
+
+558
+00:47:56,830 --> 00:48:02,170
+granules larger and larger و بتبدأ تتحلق ال
+
+559
+00:48:02,170 --> 00:48:06,090
+mitochondria و بيسموا هذه ال granules ال acidotic
+
+560
+00:48:06,090 --> 00:48:11,510
+granules ماشي اللي ممكن نشوفها في حالات أنيمة
+
+561
+00:48:11,510 --> 00:48:16,820
+مختلفةنبدأ بالأول نوع وهو الـ Hereditary يعني الـ
+
+562
+00:48:16,820 --> 00:48:21,220
+Hereditary هو عبارة عن X-linked type of inherited
+
+563
+00:48:21,220 --> 00:48:26,020
+disease غالبا بيتميز بوجود functional deficiency
+
+564
+00:48:26,020 --> 00:48:34,360
+لإنزايم اللي بتصنع ال heme-synthetic pathway أهمها
+
+565
+00:48:35,780 --> 00:48:40,080
+هو عبارة عن Delta-aminolucric acid synthetase وهو
+
+566
+00:48:40,080 --> 00:48:44,700
+عبارة عن إنزايم بيبدأ في أول سلسلة تصنيع الهيم أو
+
+567
+00:48:44,700 --> 00:48:49,340
+الferrochilates وهو عبارة عن الإنزايم المسؤول عن
+
+568
+00:48:49,340 --> 00:48:53,950
+تدخيل ال iron فيهاشفي الـPotoporphin وتكوين الهيوم
+
+569
+00:48:53,950 --> 00:48:59,810
+.مافيش الانزيمات هذه، مافيش استغلال لمين للـIron
+
+570
+00:48:59,810 --> 00:49:06,210
+وبالتالي بيصير في الصدر تجمهات للـIron في الخلايا
+
+571
+00:49:06,210 --> 00:49:14,090
+.الـaffected male had hypochromic diphoric anemia.
+
+572
+00:49:16,620 --> 00:49:20,640
+يعني فيه hypochromia وdiamorphic يعني فيه شكلين من
+
+573
+00:49:20,640 --> 00:49:25,180
+أنواع الاربسيز ماشي with mild ineffective
+
+574
+00:49:25,180 --> 00:49:28,900
+erythropoiesis and erythroid hyperplasia
+
+575
+00:49:28,900 --> 00:49:33,120
+ineffective erythropoiesis احنا عرفناه عشان
+
+576
+00:49:33,120 --> 00:49:37,580
+المصطلح بتموت الخلايا بدري في داخل الممارس وفي
+
+577
+00:49:37,580 --> 00:49:41,480
+erythroid hyperplasia hyper يعني زيادة في تصميم ال
+
+578
+00:49:41,480 --> 00:49:46,420
+erythroid seriesمن أيضًا الأنواع اللي هي led
+
+579
+00:49:46,420 --> 00:49:50,520
+poisoning اللي ال acquired من الإسم led poisoning
+
+580
+00:49:50,520 --> 00:49:54,700
+يعني فيه دخول لل led في الجسم زيادة عن اللزوم
+
+581
+00:49:54,700 --> 00:50:01,320
+غالبًا زمان كنا نشوفه يوم كانت تجينا الميه في
+
+582
+00:50:01,320 --> 00:50:06,620
+أنابيب من الرصاص لكن اليوم استبدلوا كل مؤثير
+
+583
+00:50:06,620 --> 00:50:13,020
+المياه ب plastic pipes فبالتالييعني قلت هذه
+
+584
+00:50:13,020 --> 00:50:19,060
+الظاهرة لكن لازالت موجودة في بعض الاش كضريبة من
+
+585
+00:50:19,060 --> 00:50:24,400
+ضرائب المهن المختلفة زي الناس اللي بتشتغل في
+
+586
+00:50:24,400 --> 00:50:30,580
+المحطات البترول لإن معظم البترول مليان من اللي لحق
+
+587
+00:50:30,580 --> 00:50:35,820
+بالرصاص أو اللي بيشتغلوا في البوية البوياجية لإن
+
+588
+00:50:35,820 --> 00:50:40,820
+برضه معظم البوية فيها رصاص و هكذاطيب كان بيخش
+
+589
+00:50:40,820 --> 00:50:43,920
+الجسم اللى انت جاله بيخش عن طريقتين .. بالطريقتين
+
+590
+00:50:43,920 --> 00:50:47,580
+إما by inhalation يعني أنت ممكن تستنشقه أو by
+
+591
+00:50:47,580 --> 00:50:54,140
+ingestion أو تاخده بيخش الجسم و .. متى ما دخل
+
+592
+00:50:54,140 --> 00:50:57,600
+الجسم بيصيرله accumulation بيترسق في ال bone و ال
+
+593
+00:50:57,600 --> 00:51:02,440
+bone marrow و طبعا في ال bone marrow هناك فيه
+
+594
+00:51:02,440 --> 00:51:06,940
+electrode precursor cell وبيتحلق ال mitochondrial
+
+595
+00:51:06,940 --> 00:51:13,930
+membraneوبعمل disruption للـ heme synthesis وهذا
+
+596
+00:51:13,930 --> 00:51:19,490
+بيؤدي إلى Sidroplastic changes وطبعا بيأثر على
+
+597
+00:51:19,490 --> 00:51:24,430
+الردس الممبرين و أيضا يمنع ال glycolytic activity
+
+598
+00:51:24,430 --> 00:51:29,490
+وبالتالي يقلل من ال life span تبعتها هذا بيؤدي إلى
+
+599
+00:51:29,490 --> 00:51:34,050
+mild hemolysis وبيؤدي إلى أنيميا و chronic lead
+
+600
+00:51:34,050 --> 00:51:40,590
+poisoning كيف ممكن نشخصها؟نفحص للـ LED by chemical
+
+601
+00:51:40,590 --> 00:51:45,630
+test أو بندور على الـ protoporphene ما هو المرحلة
+
+602
+00:51:45,630 --> 00:51:52,990
+التي تسبق الهيلة، بنزيد في هذه الحالة أو بنصور
+
+603
+00:51:52,990 --> 00:51:59,240
+المريضلأن صورة الأشياء العادية لأن الرصاص يوم ما
+
+604
+00:51:59,240 --> 00:52:02,900
+يكون موجود ومترثب في ال gastrointestinal tract على
+
+605
+00:52:02,900 --> 00:52:08,960
+سبيل المثال بيبين ك .. ك radio opaque fragments
+
+606
+00:52:08,960 --> 00:52:18,300
+يعني .. يعني فراغ أبيض في صورة الأشياء أيضا
+
+607
+00:52:18,300 --> 00:52:24,220
+ممكن احنا نصور العضم وبرضه العضمممكن نشوف الرصاص
+
+608
+00:52:24,220 --> 00:52:26,780
+المترسم فيه لأنه قلنا في ال bone و ال bone marrow
+
+609
+00:52:26,780 --> 00:52:32,220
+ممكن يترسم نوع التاني اللي هو ال acquired او ال
+
+610
+00:52:32,220 --> 00:52:35,780
+secondary citro plastic anemia في منها نوع اسمه
+
+611
+00:52:35,780 --> 00:52:39,040
+drug induced citro plastic anemia هو من اسم ال
+
+612
+00:52:39,040 --> 00:52:42,260
+drug يعني دخل ال drug عمل inhibition لل absorption
+
+613
+00:52:42,260 --> 00:52:46,120
+او ال inhibition لل enzyme اللي بتدخل او اللي
+
+614
+00:52:46,120 --> 00:52:52,800
+بتخدم تاخد ال iron و بتدخله بتكون في ال ريتينيعني
+
+615
+00:52:52,800 --> 00:52:55,460
+عامل inhibition لانوانزايم لان الانزيمين اللي طوا
+
+616
+00:52:55,460 --> 00:52:59,680
+حكيناهم delta-aminolucronic acid synthetase و
+
+617
+00:52:59,680 --> 00:53:04,200
+الferrochlates نفس الحكاية بس acquired هذه كانت
+
+618
+00:53:04,200 --> 00:53:11,660
+hereditary هذه المرة جاية due to إيش due to drug
+
+619
+00:53:11,660 --> 00:53:18,020
+ال mixture طبعا زيها زي اللي طوا حكيناهاطب فيه
+
+620
+00:53:18,020 --> 00:53:21,060
+other investigation قالوا أه ممكن ال urinary
+
+621
+00:53:21,060 --> 00:53:24,980
+coproporphin أحد المركبات اللي بيمر فيها تصنيع
+
+622
+00:53:24,980 --> 00:53:30,120
+الهيميا microcytic hypochromic anemia و هي بنطلع
+
+623
+00:53:30,120 --> 00:53:33,520
+على حاجة بيسموها mesophilic stippling و ال
+
+624
+00:53:33,520 --> 00:53:38,440
+mesophilic stippling بنشوفها في ال RBCs و بنشوف
+
+625
+00:53:38,440 --> 00:53:44,200
+reticulocytosis و ال mesophilic stippling
+
+626
+00:53:47,830 --> 00:53:53,290
+بيتجمع في الـcytoplasm وغالبا بيشوفه في
+
+627
+00:53:53,290 --> 00:53:58,230
+الـyoungest herpeses herpeses ليش؟ الحديثة
+
+628
+00:53:58,230 --> 00:54:03,110
+التصنيعة بيزوفيليكستيمليكي accumulation of
+
+629
+00:54:03,110 --> 00:54:08,050
+pyrimidine نيوتايد في داخل الـcytoplasm وفرسو
+
+630
+00:54:08,050 --> 00:54:12,810
+بلاستر نوع التالت اللي هو idiopathic cedroplastic
+
+631
+00:54:12,810 --> 00:54:18,230
+anemia due to unknown ودي اليوميعني زمان كانوا
+
+632
+00:54:18,230 --> 00:54:24,850
+يشوفوها في الـ Elderly People و بتعتبر اليوم نوع
+
+633
+00:54:24,850 --> 00:54:27,610
+من أنواع الـ Myelodysplastic Syndrome شلوها من
+
+634
+00:54:27,610 --> 00:54:35,070
+تصنيفات الانيميا و بيسموها Refractory Anemia with
+
+635
+00:54:35,070 --> 00:54:41,810
+Ringed Syndroblast تتميز بـ Dysarthropic Changes
+
+636
+00:54:41,810 --> 00:54:48,080
+في MacrocytosisPoikilocytosis بيزوفيليكستبليك
+
+637
+00:54:48,080 --> 00:54:55,380
+رينغسيدروبلاست وطبعا تتأخرت الاريثروبلاست في ندوشة
+
+638
+00:54:55,380 --> 00:55:00,140
+في المراحل المبكرة كمان ال platelet و ال leukocyte
+
+639
+00:55:00,140 --> 00:55:07,000
+بنشوفهم بشكل طبيعي هذا لغاية الأن كل ما يتعلق بقلة
+
+640
+00:55:07,000 --> 00:55:13,740
+ال iron مشاكل ينتج عنها أو أنيميا متختلفة الأنواع
+
+641
+00:55:13,980 --> 00:55:18,840
+نجى عن قلة في الايران طيب في disorders اللي علاقة
+
+642
+00:55:18,840 --> 00:55:22,160
+بزيادة الايران اه طبعا اذا كان فيه زيادة في انتصاص
+
+643
+00:55:22,160 --> 00:55:27,860
+الحديد في الجسم هو الحديد مشكلة انتصاصه قالوا فيه
+
+644
+00:55:27,860 --> 00:55:36,780
+3 حالات ممكن نشوفها بتنتج عن زيادة الحديد نمر واحد
+
+645
+00:55:36,780 --> 00:55:42,420
+hereditary hemochromatosis طبعا الاسم واضح جدا
+
+646
+00:55:42,420 --> 00:55:43,080
+heme
+
+647
+00:55:46,360 --> 00:55:50,380
+Hemochromatosis بمعنى انه فيه زيادة في لون الخلايا
+
+648
+00:55:50,380 --> 00:55:56,620
+اللى موجود اللى اللى اللى اللى اللى اللى اللى اللى
+
+649
+00:55:56,620 --> 00:55:57,620
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+650
+00:55:57,620 --> 00:55:57,740
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+651
+00:55:57,740 --> 00:55:57,880
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+652
+00:55:57,880 --> 00:55:58,380
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+653
+00:55:58,380 --> 00:55:58,400
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+654
+00:55:58,400 --> 00:55:58,860
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+655
+00:55:58,860 --> 00:56:00,920
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+656
+00:56:00,920 --> 00:56:00,980
+اللى اللى اللى اللى اللى اللى اللى اللى اللى اللى
+
+657
+00:56:00,980 --> 00:56:11,040
+اللى اللى اللى اللى اللى اللى اللى اللى
+
+658
+00:56:11,040 --> 00:56:15,280
+اللىنقول إنها دم زيادة عن الزومي النوع التالت
+
+659
+00:56:15,280 --> 00:56:18,840
+بيصير فيه Hemochromatosis ناتج عن إيه؟ إيش عن
+
+660
+00:56:18,840 --> 00:56:22,420
+الأكل؟ يعني بناخد كميات كبيرة من الحديد دون أن
+
+661
+00:56:22,420 --> 00:56:26,440
+ندرى أول هذه الأنواع Hereditary Hemochromatosis
+
+662
+00:56:26,440 --> 00:56:30,200
+ناتج عن إيه؟ إيش؟ هو عبارة عن multi-organ disease
+
+663
+00:56:30,200 --> 00:56:36,220
+inherited in an autosomal recessive manner وهي
+
+664
+00:56:36,220 --> 00:56:40,020
+بيعتبر most common genetic disease في ال northern
+
+665
+00:56:40,020 --> 00:56:44,950
+Europeواللي بيصير فيه انه بيصير فيه excessive
+
+666
+00:56:44,950 --> 00:56:49,470
+absorption لل iron وبالتالي بيبقى يخش ال iron في
+
+667
+00:56:49,470 --> 00:56:53,450
+داخل الجسم وبيبدأ يترسب على ال tissue زي ال
+
+668
+00:56:53,450 --> 00:56:57,730
+pancreas و ال heart و ال liver و إذا ترسب عليها هي
+
+669
+00:56:57,730 --> 00:57:02,190
+طبعا بتصير الأعضاء هذه dysfunctional في الوضع
+
+670
+00:57:02,190 --> 00:57:05,870
+الطبيعي ال iron تركيزه من اتنين لستة جرام قلنا
+
+671
+00:57:05,870 --> 00:57:10,180
+أربعة في الميللكن في حالات مرض من هنوع
+
+672
+00:57:10,180 --> 00:57:14,400
+Hemochromatosis بوصل ال concentration تبعته من 50
+
+673
+00:57:14,400 --> 00:57:21,860
+ل 60 gram هذه الأنواع تبعت ال Hemochromatosis ال
+
+674
+00:57:21,860 --> 00:57:28,480
+hereditary type ناتجة عن خلل في بعض الانزيمات طبعا
+
+675
+00:57:28,480 --> 00:57:33,060
+الانزيمات عبارة عن proteins و ال proteins المسؤول
+
+676
+00:57:33,060 --> 00:57:37,300
+عن تصنيعه gene فأي خلل في هذه ال gene غيابه
+
+677
+00:57:39,880 --> 00:57:43,880
+الـ Chromatosis كلها هذه الانزيمات بتلعب دور كبير
+
+678
+00:57:43,880 --> 00:57:49,140
+في عملية امتصاص الـ Iron إذا صار فيها خلال منة ال
+
+679
+00:57:49,140 --> 00:57:54,540
+Iron بيمتص بكميات كبيرة شو بيصير؟ pathophysiology
+
+680
+00:57:54,540 --> 00:57:58,600
+طبعا في هذا الحالة بيصير زيادة في percent of
+
+681
+00:57:58,600 --> 00:58:04,600
+saturation و transferrin وهي بالتالي بيزيد ال iron
+
+682
+00:58:04,600 --> 00:58:06,420
+absorption in the circulation
+
+683
+00:58:08,790 --> 00:58:12,870
+وبالتالي الترانسفرن بيبقى القادر على أنه ينقل
+
+684
+00:58:12,870 --> 00:58:21,870
+الحديد واحنا بنعرف أنه 30% من ال circulating iron
+
+685
+00:58:21,870 --> 00:58:26,770
+بينقل عن طريق الترانسفرن لكن في هذا الحالة كل
+
+686
+00:58:26,770 --> 00:58:28,010
+الترانسفرن مشغول
+
+687
+00:58:30,980 --> 00:58:37,780
+و these ionic iron acts as a catalyst for
+
+688
+00:58:37,780 --> 00:58:41,400
+formation of toxic oxygen radical in the presence
+
+689
+00:58:41,400 --> 00:58:47,420
+of NADH طبعا بيصير فيه free radical compoundوالـ
+
+690
+00:58:47,420 --> 00:58:49,620
+Free Radical Compound هي عبارة عن هايري توكسيك
+
+691
+00:58:49,620 --> 00:58:54,760
+سوبستانس بتهاجم أعضاء الجسم المختلفة وبالتالي ..
+
+692
+00:58:54,760 --> 00:58:57,940
+اللي .. عبارة عن اللي اترسم عليها العيرون وبالتالي
+
+693
+00:58:57,940 --> 00:59:06,780
+بيصير فيه dysfunctional or infarctional organ أشهر
+
+694
+00:59:06,780 --> 00:59:09,740
+الـ Free Radical Compound اللي بتتكون هي الـ
+
+695
+00:59:09,740 --> 00:59:17,310
+Hydroxy Radical Compound Laboratory findingبصير في
+
+696
+00:59:17,310 --> 00:59:21,790
+ريز سيرام 13 ردوس total iron binding capacity
+
+697
+00:59:21,790 --> 00:59:28,070
+وطبعا ال iron binding saturation بتزيد لأكتر من 60
+
+698
+00:59:28,070 --> 00:59:33,010
+% في ال male و أكتر من 50% في ال female لو خدنا
+
+699
+00:59:33,010 --> 00:59:36,610
+liver biopsy هنلاقي فيه زيادة في ال iron deposit
+
+700
+00:59:38,980 --> 00:59:44,120
+execution of secondary causes ممكن يتم من خلال عمل
+
+701
+00:59:44,120 --> 00:59:50,740
+blood film و مرات نحتاج نعمل bone marrow و في هذه
+
+702
+00:59:50,740 --> 00:59:56,140
+الحالة لازم نعمل screening للشخص اللي طلع عنده
+
+703
+00:59:56,140 --> 01:00:00,400
+hemochromatosis و كل عائلته كل for genetic
+
+704
+01:00:00,400 --> 01:00:07,100
+counselingهذه صورة لواحدة العظام تبعته صار فيها
+
+705
+01:00:07,100 --> 01:00:12,420
+ترسب لكميات كبيرة المفاصل في المفاصل لل iron وفي
+
+706
+01:00:12,420 --> 01:00:18,700
+بعض المناطق صار فيه اللي هو erogen فقدان لبعض
+
+707
+01:00:18,700 --> 01:00:23,880
+العظام اللي موجودة في بعض المفاصل هذا هو أيها
+
+708
+01:00:23,880 --> 01:00:29,900
+المفقودة صار في فقدان لل cartridge هذه صورة ل
+
+709
+01:00:29,900 --> 01:00:36,180
+liverفيها طبعا اللون الأزرق هذا بيعني انه في كميات
+
+710
+01:00:36,180 --> 01:00:40,380
+كبيرة من ال iron symptoms
+
+711
+01:00:40,380 --> 01:00:43,800
+Arthralgia
+
+712
+01:00:43,800 --> 01:00:52,260
+و من الاسم هذه بتكون مصحوبة من joint arthritis ثم
+
+713
+01:00:52,260 --> 01:00:56,620
+gonad ال failure both gonads سواء كان testary or
+
+714
+01:00:56,620 --> 01:01:01,340
+ovary بيصير لهم atrophyفى ال male بيصير فى
+
+715
+01:01:01,340 --> 01:01:06,920
+impotence و فى ال female بيصير فى amenorrhea بيصير
+
+716
+01:01:06,920 --> 01:01:11,380
+فى skin pigmentation طبعا تلون ال skin و طبعا
+
+717
+01:01:11,380 --> 01:01:14,320
+cardiac failure و arrhythmias، arrhythmias يعني
+
+718
+01:01:14,320 --> 01:01:18,380
+خلل فى ضربات القلب ثم ضيابيتس إذا كان اترسب على
+
+719
+01:01:18,380 --> 01:01:25,320
+البنجرياز ثم ثم
+
+720
+01:01:25,320 --> 01:01:31,330
+cirrhosis و abdominal painTreatment بيعملوا vein
+
+721
+01:01:31,330 --> 01:01:38,030
+section لكل ال iron اللي موجود و اليوم طبعا صاروا
+
+722
+01:01:38,030 --> 01:01:43,030
+يستخدموا iron chelating agent اللي هو الدسفرال و
+
+723
+01:01:43,030 --> 01:01:48,950
+هي عبارة عن مادة بتحقن في المريض و بالتالي بيبدأ
+
+724
+01:01:48,950 --> 01:01:56,630
+يعمل chelation لكل ال iron ال prognosis اللي بيصير
+
+725
+01:01:56,630 --> 01:02:01,220
+فيه arthropathyبصير فيه hypogonadism بصير فيه
+
+726
+01:02:01,220 --> 01:02:09,460
+hepatic cirrhosis وغالبا ما
+
+727
+01:02:09,460 --> 01:02:16,640
+بتتحسن بالعلاج يوم ما انعالج المرضى يعني المرضى
+
+728
+01:02:16,640 --> 01:02:18,760
+اللى بتعالجه بالكميات كاميرة
+
+729
+01:02:40,770 --> 01:02:46,990
+مقارنة بـ 67% من الذين لم يتم علاجهم يعني الناس
+
+730
+01:02:46,990 --> 01:03:00,330
+اللي نديهم علاج مكثف 11% منهم عاش خمس سنوات زيادة
+
+731
+01:03:01,920 --> 01:03:09,160
+بالمقابل 67% من اكتر من الناس اللي 67% طبعا
+
+732
+01:03:09,160 --> 01:03:14,080
+مااخدوش العداج ايه بقى توصله ل carcinoma, cardiac
+
+733
+01:03:14,080 --> 01:03:20,180
+disease ال liver failure all caused by this النوع
+
+734
+01:03:20,180 --> 01:03:22,420
+التاني من ال hemochromatosis الناس اللي بتاخد كمية
+
+735
+01:03:22,420 --> 01:03:27,620
+دم كتيرة اتفقنا على نوحدة الدم فيها 250 ميلي جرام
+
+736
+01:03:27,980 --> 01:03:32,020
+من ال iron وبالتالي الناس اللي بتاخد كميات كبيرة
+
+737
+01:03:32,020 --> 01:03:36,300
+من الدم بيترسم فيها ال iron بكميات كبيرة نوع
+
+738
+01:03:36,300 --> 01:03:40,580
+التالت dietary cause طبعا ال dietary ممكن يصير عن
+
+739
+01:03:40,580 --> 01:03:49,460
+طريق الأكل بيخش الأكل طبعا و هذا حالات سجنة زيادة
+
+740
+01:03:49,460 --> 01:03:56,420
+ال iron للناس اللي بتطبخ في أواني حديدية اوفي بعض
+
+741
+01:03:56,420 --> 01:03:59,400
+المرات بيشير في acute iron poisoning الناس اللي ..
+
+742
+01:03:59,400 --> 01:04:03,580
+الأطفال اللي بيشربوا اللي هو الكميات كبيرة من ال
+
+743
+01:04:03,580 --> 01:04:07,080
+iron أو الناس اللي بتحاول تنتحر فبتاخد كميات كبيرة
+
+744
+01:04:07,080 --> 01:04:14,160
+من حبوب الحديد ال .. ال chronic use كمان of iron
+
+745
+01:04:14,160 --> 01:04:17,040
+supplementation في كناس كتير بتاخد أكتر من course
+
+746
+01:04:17,040 --> 01:04:22,330
+من courses الحديد وبالتالي بيبدأ بيأثر تأثيريزيد
+
+747
+01:04:22,330 --> 01:04:30,430
+الحديد في الجسم و بهيك بيكون انتهينا من المحاضرة
+
+748
+01:04:30,430 --> 01:04:36,370
+التانية ارجو ان تكونوا قد استمتعتم فيها
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o.srt
new file mode 100644
index 0000000000000000000000000000000000000000..94920dd0e934f866036b1dd913abca9c4da4e3a7
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o.srt
@@ -0,0 +1,1131 @@
+1
+00:00:01,870 --> 00:00:04,910
+بسم الله الرحمن الرحيم والصلاة والسلام على سيد
+
+2
+00:00:04,910 --> 00:00:11,290
+الخلق أجمعين سيدنا محمد الصادق الأمين وبعد ننتقل 
+
+3
+00:00:11,290 --> 00:00:15,570
+الآن إلى الجزء الثاني من المادة وهو ما يتعلق
+
+4
+00:00:15,570 --> 00:00:23,990
+بـالأمراض الـ white blood cell وطبعا أشهر هذه
+
+5
+00:00:23,990 --> 00:00:27,650
+الأمراض هي Malignancy of white blood cell أو 
+
+6
+00:00:27,650 --> 00:00:33,880
+Malignancy of Hemopoietic tissue وهي بالله كيميا
+
+7
+00:00:36,230 --> 00:00:43,070
+إضافة إلى أنه في تقسيمة هنطلق إليها بتقسم هذه
+
+8
+00:00:43,070 --> 00:00:48,070
+الأمراض إلى خمس عائلات أساسية هننتقل إليها إن شاء
+
+9
+00:00:48,070 --> 00:00:52,590
+الله بالتفصيل إنما في هذه المحاضرة هنعرف وهنطلق 
+
+10
+00:00:52,590 --> 00:00:57,930
+إلى المصطلحات التالية نمر واحد الـ definition ثم الـ
+
+11
+00:00:57,930 --> 00:01:03,010
+historic perspective ثم أسبابها الـ etiology and 
+
+12
+00:01:03,010 --> 00:01:08,170
+risk factors ثم الـ incidence و الـ classification و
+
+13
+00:01:08,170 --> 00:01:11,770
+سنقارن في النهاية ما بين الـ acute و الـ chronic
+
+14
+00:01:11,770 --> 00:01:18,550
+leukemia إن شاء الله by
+
+15
+00:01:18,550 --> 00:01:23,170
+definition الـ leukemia هي عبارة عن malignant
+
+16
+00:01:23,170 --> 00:01:26,950
+disease of hemopoietic tissue لماذا تتميز؟ كانت
+
+17
+00:01:26,950 --> 00:01:31,550
+تتميز بـ accumulation of abnormal white blood cell
+
+18
+00:01:31,550 --> 00:01:37,370
+في الـ hemopoietic tissue ويسموا الـ Abnormal White
+
+19
+00:01:37,370 --> 00:01:43,090
+Blood Cell بيعتوها لقب Neoplastic Cell أو Leukemic
+
+20
+00:01:43,090 --> 00:01:50,170
+Cell طبعا هذا الكلام هو بيتميز و بيزيد بيزيد في الـ
+
+21
+00:01:50,170 --> 00:01:53,750
+hemopoietic tissue زي ما قلنا وطبعا الـ major
+
+22
+00:01:53,750 --> 00:01:56,390
+hemopoietic tissue هي عبارة عن الـ bone marrow
+
+23
+00:01:56,390 --> 00:02:03,390
+بيؤدي هذا إلى الـ bone marrow failure  وأيضا يؤدي
+
+24
+00:02:03,390 --> 00:02:08,190
+إلى زيادة في الـ white blood cell والحاجة التالتة
+
+25
+00:02:08,190 --> 00:02:12,330
+اللي بتصاحب اللوكيميا هي أن الخلية السرطانية 
+
+26
+00:02:12,330 --> 00:02:16,610
+بتغذو أعضاء الجسم المختلفة أشهرها الـ liver و
+
+27
+00:02:16,610 --> 00:02:19,630
+الـ spleen و الـ lymph nodes و الـ brain
+
+28
+00:02:22,090 --> 00:02:26,330
+اللوكيميا الشغل الأولانية أنه بيصير فيه raised في 
+
+29
+00:02:26,330 --> 00:02:29,870
+الـ circulating white blood cell يعني بيصير فيه 
+
+30
+00:02:29,870 --> 00:02:34,550
+leukocytosis الحاجة التانية بيصير فيه monomalophia
+
+31
+00:02:34,550 --> 00:02:38,410
+فاحنا هنعرف على هذا المصطلح إن شاء الله والحاجة
+
+32
+00:02:38,410 --> 00:02:44,610
+التالتة infiltration of body organs المختلفة 
+
+33
+00:02:44,800 --> 00:02:49,280
+Historic Perspective أول ما نحكي عن اللوكيميا هو 
+
+34
+00:02:49,280 --> 00:02:56,160
+يوصفها في 1945 عالمين واحد في سكوتلاند اسمه penit 
+
+35
+00:02:56,160 --> 00:03:04,200
+والثاني في ألمانيا الـ etiology and risk factor الـ
+
+36
+00:03:04,200 --> 00:03:07,020
+etiology of اللوكيميا is unknown
+
+37
+00:03:09,270 --> 00:03:17,890
+It's unknown leukemia مرض من الأمراض التي لا يعرف 
+
+38
+00:03:17,890 --> 00:03:22,830
+سببها وأنت مافيه risk factor بتصاحب أو بتؤدي إلى
+
+39
+00:03:22,830 --> 00:03:28,250
+تكوين الـ leukemia unknown الـ leukemia unknown مرة
+
+40
+00:03:28,250 --> 00:03:35,470
+ثانية الخلية سليمة في لحظة من اللحظات تقرر أن 
+
+41
+00:03:35,470 --> 00:03:42,810
+تنقسم انقسامات غير طبيعية السبب أن يبدأ رب العباد
+
+42
+00:03:42,810 --> 00:03:48,930
+هو من يسير هذه الخلايا في لحظة من اللحظات ممكن أي 
+
+43
+00:03:48,930 --> 00:03:53,810
+إنسان يتعرض إلى leukemia risk factor associated
+
+44
+00:03:53,810 --> 00:03:59,320
+with that أول مرة واحد oncogene mutation and human
+
+45
+00:03:59,320 --> 00:04:04,260
+suppressor gene alteration واتنين هنطلق إلى موضوع 
+
+46
+00:04:04,260 --> 00:04:07,940
+الـ host factor وفي الآخر هنحكي على الـ
+
+47
+00:04:07,940 --> 00:04:12,920
+environmental factor that increase the tendency of 
+
+48
+00:04:12,920 --> 00:04:18,070
+leukemia طبعا كل كنا عارفين هذه الصورة هذه الصورة
+
+49
+00:04:18,070 --> 00:04:21,290
+هي عبارة عن الـ hemopoietic tree هي الـ stem cell
+
+50
+00:04:21,290 --> 00:04:26,610
+تنقسم وتدينا أما lymphoid وأما myeloid ثم هذه
+
+51
+00:04:26,610 --> 00:04:31,370
+الخلايا تنقسم انقسامات مختلفة لغاية ما تصل الـ
+
+52
+00:04:31,370 --> 00:04:42,350
+mature form في هذه المراحل إيه يتعرض لانقسامات 
+
+53
+00:04:42,350 --> 00:04:48,860
+هذه أي خلل في الجينات المسؤول عن انتقال الخلية من
+
+54
+00:04:48,860 --> 00:04:53,360
+الـ mature إلى الـ mature form هذه عبارة عن جينات
+
+55
+00:04:53,360 --> 00:04:58,160
+تؤدي لانقسامات ماشي أي خلل في هذه الجينات يؤدي الـ
+
+56
+00:04:58,160 --> 00:05:04,720
+اللوكيميا اشتغل هذه الـ mutation أو الـ gene 
+
+57
+00:05:04,720 --> 00:05:09,160
+abnormality اللي هي الـ oncogen mutation tumor
+
+58
+00:05:09,160 --> 00:05:14,120
+suppressor gene Chromosomal abnormality and gene 
+
+59
+00:05:14,120 --> 00:05:17,500
+rearrangement زي ما تشوفهم في أي مرحلة من المراحل 
+
+60
+00:05:17,500 --> 00:05:22,700
+هذه الأسهم تؤدي أو تشير إلى المراحل المختلفة التي 
+
+61
+00:05:22,700 --> 00:05:28,600
+تمر بها الخلية ما هو دور الجين أو الـ onco gene في
+
+62
+00:05:28,600 --> 00:05:32,660
+الـ hemibiotic malignancy يعني الـ human genome
+
+63
+00:05:32,660 --> 00:05:37,620
+بيتكون من جينات normally healthy gene بيسمى proto
+
+64
+00:05:37,620 --> 00:05:43,950
+onco gene and these genes code for protein وهذه
+
+65
+00:05:43,950 --> 00:05:46,950
+البروتينة تعمل كشخصية أكثر تعمل كشخصية أكثر تعمل
+
+66
+00:05:46,950 --> 00:05:47,450
+كشخصية أكثر تعمل كشخصية أكثر تعمل
+
+67
+00:05:47,450 --> 00:05:49,370
+كشخصية أكثر تعمل كشخصية أكثر تعمل
+
+68
+00:05:49,370 --> 00:05:52,310
+كشخصية أكثر تعمل كشخصية أكثر تعمل
+
+69
+00:05:52,310 --> 00:05:58,990
+كشخصية أكثر تعمل كشخصية أكثر تعمل
+
+70
+00:05:58,990 --> 00:06:05,050
+كشخصية أكثر تعمل كشخصية أكثر تعمل 
+
+71
+00:06:05,050 --> 00:06:12,830
+كشخصية أكثر تعمل كشخصية 
+
+72
+00:06:12,830 --> 00:06:19,590
+أكثر هذه الجينات أن أي خلل فيها يؤدي إلى Malignant
+
+73
+00:06:19,590 --> 00:06:25,390
+Transformation الخلل
+
+74
+00:06:25,390 --> 00:06:32,090
+اللي سجله في هذه الجينات اللي غالبا مصحوب أو موج
+
+75
+00:06:32,090 --> 00:06:35,730
+ود أو ددق في الهيموبيوتك مالجنانسي لجوا أربعة نوع من
+
+76
+00:06:35,730 --> 00:06:40,570
+الـ disorders translocation and inversion deletion
+
+77
+00:06:40,570 --> 00:06:45,220
+and numerical aberration and point mutation و gene 
+
+78
+00:06:45,220 --> 00:06:49,380
+amplification طيب
+
+79
+00:06:49,380 --> 00:06:56,860
+نيجي للـ host factor نجي له الـ host factor بيندرج 
+
+80
+00:06:56,860 --> 00:07:02,220
+تحته التالي congenital chromosome abnormality و
+
+81
+00:07:02,220 --> 00:07:10,240
+طبعا أي ناس أي مرضى عندهم زيادة في frequency of
+
+82
+00:07:10,240 --> 00:07:12,180
+congenital disorders
+
+83
+00:07:19,050 --> 00:07:25,210
+أشهر هذه الأمراض زي الـ bloom syndrome طبعا عارفين 
+
+84
+00:07:25,210 --> 00:07:30,040
+فانكونيزي أليميا Down syndrome climb filter
+
+85
+00:07:30,040 --> 00:07:32,280
+syndrome كلها عبارة عن أمراض أخدتها في الـ 
+
+86
+00:07:32,280 --> 00:07:37,440
+molecular إن شاء الله فهذه كلها عبارة عن أمراض
+
+87
+00:07:37,440 --> 00:07:44,460
+بيزيد فيها الـ chromosome aberration و instability of
+
+88
+00:07:44,460 --> 00:07:50,790
+chromosome طبعا الناس هذولا وجدوا أن إمكانية حدوث 
+
+89
+00:07:50,790 --> 00:07:54,230
+الـ acute leukemia عندهم بتزيد عن الـ healthy people
+
+90
+00:07:54,230 --> 00:08:00,210
+أو عن الناس اللي طبيعيين 18 لعشرين فرمية
+
+91
+00:08:00,210 --> 00:08:06,590
+18 مرة لعشرين مرة زيادة في الـ incidence of
+
+92
+00:08:06,590 --> 00:08:11,370
+acute leukemia عندهم عن الناس الـ healthy وهذا 
+
+93
+00:08:11,370 --> 00:08:16,170
+التحديد الإحصائي عملوه على الـ down syndrome الحاجة
+
+94
+00:08:16,170 --> 00:08:21,270
+الثانية الـ Immunodeficiency يعني خلل أو نقص في
+
+95
+00:08:21,270 --> 00:08:27,600
+جهاز المناعة طبعا احنا بنعرف أن الجهاز المناعة is 
+
+96
+00:08:27,600 --> 00:08:32,660
+associated أو مسؤول من عنه اللي مسؤول عنه الـ B وT
+
+97
+00:08:32,660 --> 00:08:36,280
+lymphocyte وبالتالي أي خلل في الـ gene
+
+98
+00:08:36,280 --> 00:08:40,540
+rearrangement of T وB lymphocyte هيؤدي إلى
+
+99
+00:08:40,540 --> 00:08:44,600
+immunodeficiency status أشهر هذه الأمراض المصحوبة 
+
+100
+00:08:44,600 --> 00:08:50,520
+بهذه الحالة هي التكسياتيليانجكتازيا six-linked
+
+101
+00:08:50,520 --> 00:08:51,880
+egamoglobulin
+
+102
+00:08:55,730 --> 00:08:59,710
+نمرة ثلاثة chronic bone marrow dysfunction من الاسم
+
+103
+00:08:59,710 --> 00:09:05,230
+dysfunction and chronic لمين للـ bone marrow هذا هيزود الـ
+
+104
+00:09:05,230 --> 00:09:10,230
+risk of acute leukemia وأمثل على ذلك الـ 
+
+105
+00:09:10,230 --> 00:09:14,190
+myelodysplastic syndrome و الـ myeloproniferative 
+
+106
+00:09:14,190 --> 00:09:22,150
+disorders aplastic anemia and PIH هنطرق للمصطلحات
+
+107
+00:09:22,150 --> 00:09:27,540
+تجلجوش السبب الأخير هو الـ environmental factor أو
+
+108
+00:09:27,540 --> 00:09:32,220
+العنوان الأخير الـ environmental يعني اتعرض الإنسان
+
+109
+00:09:32,220 --> 00:09:35,680
+لبيئة غير طبيعية من أشهر هذه البيئات الغير طبيعية
+
+110
+00:09:35,680 --> 00:09:40,420
+ionizing radiation و كنا شوفنا شو صار في اليابان 
+
+111
+00:09:40,420 --> 00:09:45,360
+في لما طبعا
+
+112
+00:09:45,360 --> 00:09:51,240
+اتعرضوا إلى الـ Hiroshima Nagasaki bomb أو nuclear 
+
+113
+00:09:51,240 --> 00:09:57,110
+bomb في Hiroshima و Nagasaki وشو صار في العراق و
+
+114
+00:09:57,110 --> 00:10:02,410
+حتى شو صار في بلادنا طبعا هذه كلها عبارة عن أن الـ
+
+115
+00:10:02,410 --> 00:10:06,230
+ionizing radiation is associated with acute and
+
+116
+00:10:06,230 --> 00:10:11,610
+chronic leukemia سجلة حالات في بعدها في كل أنواع
+
+117
+00:10:11,610 --> 00:10:16,850
+الـ leukemia أيضا سجلة حالات في الـ lymphoma
+
+118
+00:10:16,850 --> 00:10:24,150
+وبالتالي كل أنواع الـ leukemia سجلة فيها الـ ALL اللي 
+
+119
+00:10:24,150 --> 00:10:27,390
+هو acute myelogenous leukemia acute lymphoplastic 
+
+120
+00:10:27,390 --> 00:10:30,910
+leukemia chronic myelogenous leukemia كلها عبارة 
+
+121
+00:10:30,910 --> 00:10:41,030
+عن حالات سجلت drugs أيضا سجلت حالات من الـ leukemic
+
+122
+00:10:41,030 --> 00:10:48,460
+transformation associated with drug طبعا أشهر هذه 
+
+123
+00:10:48,460 --> 00:10:52,560
+الـ drugs هو الـ benzene, chloraphenicol, 
+
+124
+00:10:52,660 --> 00:10:55,780
+renalputazone, and cytotoxic alkylating 
+
+125
+00:10:55,780 --> 00:11:00,100
+chemotherapeutic agents الناس اللي بتاخدوا كيماوي 
+
+126
+00:11:00,100 --> 00:11:04,680
+شو بعمل الكيماوي؟ قالوا الكيماوي هو أو الـ 
+
+127
+00:11:04,680 --> 00:11:08,700
+cytotoxic alkylating chemotherapeutic agent هو 
+
+128
+00:11:08,700 --> 00:11:12,200
+عبارة عن strongly electrophilic agents
+
+129
+00:11:14,530 --> 00:11:19,050
+بتطبق nucleophilic attack على الـ DNA nucleophilic attack
+
+130
+00:11:19,050 --> 00:11:27,230
+يعني nucleophilic attack
+
+131
+00:11:27,230 --> 00:11:31,530
+nucleophilic attack nucleophilic attack
+
+132
+00:11:31,530 --> 00:11:35,130
+nucleophilic attack nucleophilic attack nucleophilic attack nucleophilic attack
+
+133
+00:11:35,130 --> 00:11:35,970
+nucleophilic attack nucleophilic attack nucleophilic attack nucleophilic attack
+
+134
+00:11:35,970 --> 00:11:38,470
+nucleophilic attack nucleophilic attack nucleophilic attack nucleophilic attack
+
+135
+00:11:38,470 --> 00:11:40,350
+nucleophilic attack
+
+136
+00:11:44,870 --> 00:11:50,350
+بيأتي لـ strand breaks, complex, rearrangement
+
+137
+00:11:50,350 --> 00:11:53,950
+بيأتي لـ deletion of part or all of the chromosome
+
+138
+00:11:53,950 --> 00:11:59,490
+شوف الفرق بينها، بين اللوكيميا اللي بتنتج عن الـ
+
+139
+00:11:59,490 --> 00:12:01,730
+chemotherapy يعني الـ therapy induced و بين
+
+140
+00:12:01,730 --> 00:12:05,770
+اللوكيميا الأصلية قالوا في ثلاث فروقات أساسية
+
+141
+00:12:05,770 --> 00:12:12,750
+الفرق الأول يعني في ال therapy induced acute non
+
+142
+00:12:12,750 --> 00:12:17,730
+lymphoplastic leukemia cases تسعين فالمية من
+
+143
+00:12:17,730 --> 00:12:21,570
+الحالات عندهم chromosomal cytogenetic abnormality
+
+144
+00:12:23,610 --> 00:12:26,850
+أشهر هذه ال cytogenetic abnormality أو الكروموسوم
+
+145
+00:12:26,850 --> 00:12:32,010
+الابنورمالي هو ال monosomy 5, 5Q-, monosomy 7,
+
+146
+00:12:32,150 --> 00:12:37,790
+and 7Q-, بينما أقل من 60% في الـ de novo  يعني
+
+147
+00:12:37,790 --> 00:12:41,670
+الأصلية cases
+
+148
+00:12:41,670 --> 00:12:46,610
+عندهم cytogenetic abnormality و كروموسوم رقم خمسة
+
+149
+00:12:46,610 --> 00:12:55,940
+وسبعة usually are involved less commonlyالسبب
+
+150
+00:12:55,940 --> 00:13:00,040
+الثاني أو العامل التفارقي الثاني هو أكثر من ثلتين
+
+151
+00:13:00,040 --> 00:13:05,660
+حالات ثلاسيميا لوكيميا غالباً بيسبقها مرحلة
+
+152
+00:13:05,660 --> 00:13:11,690
+بيسموها pre-leukemic phase وفي هذه المرحلة اللي
+
+153
+00:13:11,690 --> 00:13:16,310
+بيكون فيه severe dysplastic changes و ineffective
+
+154
+00:13:16,310 --> 00:13:20,750
+hemopoiesis أنت يعني مايعرفش يعني ineffective
+
+155
+00:13:20,750 --> 00:13:27,990
+hemopoiesis يعني premature cell death and in de
+
+156
+00:13:27,990 --> 00:13:34,630
+novo ال pre leukemic states أو phase بيحدث في أقل
+
+157
+00:13:34,630 --> 00:13:39,320
+من الربع هناك الثلتين أقل من الربعالفرق الثالث
+
+158
+00:13:39,320 --> 00:13:42,920
+ال therapy induced is a refractory treatment و
+
+159
+00:13:42,920 --> 00:13:47,260
+المريض ما يعيش أكثر من أربع شهور بينما ال de novo
+
+160
+00:13:47,260 --> 00:13:49,380
+ممكن يعيش عشرين شهر
+
+161
+00:13:53,230 --> 00:13:57,470
+النقطة الثانية هي ال chemicals ويقولنا تعرض
+
+162
+00:13:57,470 --> 00:14:00,330
+الإنسان إلى chemicals زي البنزين زي ال cigarette
+
+163
+00:14:00,330 --> 00:14:05,310
+smokers زي المزارعين اللي بتعرضوا للمبيدات الحشرية
+
+164
+00:14:05,310 --> 00:14:11,650
+زي ال rubber industry workers زي حتى أطفال عاملين
+
+165
+00:14:11,650 --> 00:14:13,970
+في ال industry workers
+
+166
+00:14:17,690 --> 00:14:28,290
+والناس اللي مخدرين الاناستيزيا أيضاً بيتعرضوا للفيروس
+
+167
+00:14:28,290 --> 00:14:37,370
+سجلت حالات كثيرة طبعاً associated with leukemia أشهر
+
+168
+00:14:37,370 --> 00:14:40,890
+هذه الحالات أمثل عليها هي human T cell leukemia
+
+169
+00:14:40,890 --> 00:14:47,290
+الفيروس واحد وجدوه هو عبارة عن causative agent لل
+
+170
+00:14:47,290 --> 00:14:54,530
+other T cell leukemia و ال HTLV2 وجدوه في atypical
+
+171
+00:14:54,530 --> 00:14:57,510
+hairy اللوكيميا ويعني هو من أنواع chronic
+
+172
+00:14:57,510 --> 00:14:59,150
+lymphocytic leukemia
+
+173
+00:15:02,600 --> 00:15:07,900
+موجود في البركتس الفومة وأول ما اكتشفوا هذه
+
+174
+00:15:07,900 --> 00:15:11,220
+الشغلات كانوا بيعتبروها ال causative agent يعني
+
+175
+00:15:11,220 --> 00:15:15,600
+المسبب الأساسي لللوكيميا هي عبارة عن ال virus
+
+176
+00:15:15,600 --> 00:15:18,700
+incidence
+
+177
+00:15:18,700 --> 00:15:23,460
+ال overall incidence لللوكيميا هي ثمانية عشر
+
+178
+00:15:23,460 --> 00:15:29,640
+حالة لكل مئة ألف من ال population سنوياً يعني في
+
+179
+00:15:29,640 --> 00:15:38,450
+بلادنا فيه 2 مليون يعني فعلاً من 160 حالة إلى 200
+
+180
+00:15:38,450 --> 00:15:45,390
+حالة سنوياً في غزة أو في قطاع غزة نصف هذه الحالات
+
+181
+00:15:45,390 --> 00:15:51,190
+acute ونصف الثاني chronic ولوكيميا بشكل عام تصيب
+
+182
+00:15:51,190 --> 00:15:57,390
+ال adult أكثر من الأطفال بنسبة عشرة إلى واحد
+
+183
+00:15:58,880 --> 00:16:05,420
+وغالباً ال male أكثر من ال female بنسبة 1 إلى 2 إلى
+
+184
+00:16:05,420 --> 00:16:09,340
+1 بشكل
+
+185
+00:16:09,340 --> 00:16:12,880
+عام اللوكيميا بتصيب كل الأعمار لكن وجدوا أن ال
+
+186
+00:16:12,880 --> 00:16:17,180
+acute lymphoplastic leukemia بتصيب الأطفال بينما ال
+
+187
+00:16:17,180 --> 00:16:22,560
+acute myelogenous leukemia بتصيب الأكبر 75% من
+
+188
+00:16:22,560 --> 00:16:25,980
+حالات ال childhood leukemia هي عبارة عن acute
+
+189
+00:16:25,980 --> 00:16:30,550
+lymphoplastic leukemia بينما 80% من حالة ال Acute
+
+190
+00:16:30,550 --> 00:16:34,550
+Myelogenous Leukemia بتشوفها في دكاترة ال chronic
+
+191
+00:16:34,550 --> 00:16:39,150
+leukemia بشكل عام هي عبارة عن disease of adult
+
+192
+00:16:39,150 --> 00:16:45,070
+chronic lymphocytic leukemia خصوصاً في الأطفال
+
+193
+00:16:45,070 --> 00:16:53,350
+وغالباً ما نشاهدها قبل سن الأربعين  الـMyelogenous
+
+194
+00:16:53,350 --> 00:16:55,570
+اللوكيميا اللوكيميا اللوكيميا اللوكيميا اللوكيميا
+
+195
+00:16:55,570 --> 00:17:02,050
+اللوكيميا اللوكيميا اللوكيميا اللوكيميا اللوكيميا
+
+196
+00:17:02,050 --> 00:17:02,350
+اللوكيميا اللوكيميا اللوكيميا اللوكيميا اللوكيميا
+
+197
+00:17:02,350 --> 00:17:02,970
+اللوكيميا اللوكيميا اللوكيميا اللوكيميا اللوكيميا
+
+198
+00:17:02,970 --> 00:17:04,570
+اللوكيميا اللوكيميا اللوكيميا اللوكيميا اللوكيميا
+
+199
+00:17:04,570 --> 00:17:12,510
+اللوكيميا اللوكيميا هذه تقسيمة بشكل عام للأطفال
+
+200
+00:17:12,510 --> 00:17:17,470
+in terms of ال leukemia classification of leukemia
+
+201
+00:17:17,470 --> 00:17:23,870
+قسموها إلى acute و chronic ويقسم ال acute إلى
+
+202
+00:17:23,870 --> 00:17:27,690
+myeloid
+
+203
+00:17:27,690 --> 00:17:31,960
+و lymphoid حسب نوع الخلية وجاروا ال myeloid عبارة
+
+204
+00:17:31,960 --> 00:17:38,520
+عن ثمان أنواع وأعطوها رمز M من Myeloid أول حرف من
+
+205
+00:17:38,520 --> 00:17:43,340
+Myeloid وباقيها ثمان أنواع دوها عرقاب سهولة الـ H
+
+206
+00:17:43,340 --> 00:17:50,220
+التفريق في M0, M1, M2 لغاية M7 بينما ال Lymphoid
+
+207
+00:17:50,220 --> 00:17:56,880
+أعطوها أول حرف من Lymphoid وهو L فصار في عندنا acute
+
+208
+00:17:56,880 --> 00:17:59,860
+lymphoplastic leukemia و acute myelogenous
+
+209
+00:17:59,860 --> 00:18:03,620
+leukemia وجاروا ال acute lymphoplastic تلات أنواع
+
+210
+00:18:03,620 --> 00:18:08,420
+الواحد والاثنين والثلاث أيضاً ال chronic leukemia
+
+211
+00:18:08,420 --> 00:18:12,940
+according to the type of cells involved جاروا هي
+
+212
+00:18:12,940 --> 00:18:16,780
+عبارة عن myeloid و lymphoid فأشهر أنواع ال myeloid
+
+213
+00:18:16,780 --> 00:18:20,860
+هي chronic myelogenous leukemia بينما ال lymphoid
+
+214
+00:18:20,860 --> 00:18:24,980
+يندرج تحتها أكثر من نوع زي ال chronic lymphocytic
+
+215
+00:18:24,980 --> 00:18:29,400
+leukemia pro lymphocytic leukemia hairy cell leukemia
+
+216
+00:18:29,400 --> 00:18:35,180
+هتترخ ليه كل هذه الأنواع إن شاء الله نهاية ال
+
+217
+00:18:35,180 --> 00:18:41,580
+course زي ما قلت لكم قسموا ال leukemia لخمس عائلات
+
+218
+00:18:41,580 --> 00:18:47,860
+أساسية كل عائلة هي ال acute leukemia ثم ال
+
+219
+00:18:47,860 --> 00:18:56,310
+chronic leukemia ميلوديس بلاستيك سندروم ميلوديس
+
+220
+00:18:56,310 --> 00:19:05,210
+بلاستيك
+
+221
+00:19:05,210 --> 00:19:11,740
+سندروم ميلوديس بلاستيك سندروم عائلة أخرى بردو واحد
+
+222
+00:19:11,740 --> 00:19:15,280
+نيجي ليها بالتفصيل ثم non-leukemic
+
+223
+00:19:15,280 --> 00:19:19,960
+myeloproliferative disorders هي مش leukemia لكن في
+
+224
+00:19:19,960 --> 00:19:25,500
+proliferative يعني high proliferative capacity ثم
+
+225
+00:19:25,500 --> 00:19:29,140
+non-leukemic lymphoproliferative disorders
+
+226
+00:19:29,140 --> 00:19:32,760
+according to the cell type either مقسمها إلى نوعين
+
+227
+00:19:32,760 --> 00:19:38,760
+ال myeloid و ال lymphoid فهي خمس عائلات أساسية إن
+
+228
+00:19:38,760 --> 00:19:43,800
+شاء الله احنا نتفرع لكل هذه الأنواع بالتفصيل بشكل
+
+229
+00:19:43,800 --> 00:19:46,160
+عام الأكيد اللوكيميا by definition هي بره عن
+
+230
+00:19:46,160 --> 00:19:50,300
+اللوكيميا اللي بتتميز ب uncontrolled proliferation
+
+231
+00:19:50,300 --> 00:19:54,920
+of poorly differentiated cells ايش يعني poorly
+
+232
+00:19:54,920 --> 00:19:59,800
+differentiated يعني اللي لسه مش ناضجة ال immature
+
+233
+00:19:59,800 --> 00:20:06,930
+cell بيسموها في هذه الحالة blast cell فال Leukemia
+
+234
+00:20:06,930 --> 00:20:10,810
+لكن ال Acute Leukemia بتتميز بزيادة في عدد ايش
+
+235
+00:20:10,810 --> 00:20:15,850
+ال blasts وقسموها لنوعين according to the predominant
+
+236
+00:20:15,850 --> 00:20:20,770
+cell lineage إلى Acute lymphoplastic و Acute non
+
+237
+00:20:20,770 --> 00:20:24,050
+lymphoplastic leukemia أو بيسموها Acute
+
+238
+00:20:24,050 --> 00:20:28,310
+myelogenous leukemia وهذه التقسيمة اللي حكينا
+
+239
+00:20:28,310 --> 00:20:33,190
+عليها ال Acute myeloid و ال non myeloid
+
+240
+00:20:35,230 --> 00:20:40,670
+وقلنا ال AML هي ثمان أنواع وال ALL هي تلات أنواع
+
+241
+00:20:40,670 --> 00:20:45,010
+ال chronic leukemia بتختلف عن ال acute leukemia أن
+
+242
+00:20:45,010 --> 00:20:50,530
+الخلايا الموجود المصابة فيها هي عبارة عن خلايا
+
+243
+00:20:50,530 --> 00:20:55,900
+تقريباً mature ماشي some characteristic of maturity
+
+244
+00:20:55,900 --> 00:21:00,080
+بتكون واضحة جداً في ال chronic leukemia وفي أنواع
+
+245
+00:21:00,080 --> 00:21:03,580
+كثيرة زي ما قلنا هتطلع لكم ليها chronic lymphocytic
+
+246
+00:21:03,580 --> 00:21:06,740
+leukemia, pro lymphocytic leukemia, hairy
+
+247
+00:21:06,740 --> 00:21:11,100
+cell leukemia and CML أو chronic myeloid leukemia
+
+248
+00:21:13,060 --> 00:21:16,900
+myelodysplastic syndrome عرفوها في البداية هي
+
+249
+00:21:16,900 --> 00:21:21,040
+عبارة عن ال leukemic condition يعني حالة بتسبق
+
+250
+00:21:21,040 --> 00:21:25,840
+اللوكيميا يعني مرض من هالنوع بيجلب لللوكيميا قسموه
+
+251
+00:21:25,840 --> 00:21:30,760
+according to the FAB ايه ال criteria FAB يا جماعة
+
+252
+00:21:30,760 --> 00:21:35,240
+الخير اختصار ل French American British scientists
+
+253
+00:21:35,240 --> 00:21:41,550
+مجموعة من العلماء الامريكان والبريطانيين والفرنسيين
+
+254
+00:21:41,550 --> 00:21:44,510
+جلسوا وعملوا Classification لكل أنواع اللوكيميا
+
+255
+00:21:44,510 --> 00:21:48,930
+قالوا أنا خمس أنواع Refractory Anemia Refractory
+
+256
+00:21:48,930 --> 00:21:52,350
+Anemia with Excess Blast Refractory Anemia with
+
+257
+00:21:52,350 --> 00:21:56,370
+Excess Blast ثم Refractory Anemia with Excess
+
+258
+00:21:56,370 --> 00:21:59,170
+Blast and Transformation and Chronic
+
+259
+00:21:59,170 --> 00:22:06,130
+Myelomonocytic Leukemia وسبب أن اللوكيميك غالباً
+
+260
+00:22:06,130 --> 00:22:12,300
+ال disorder قسموها لنوعين بيندرج تحتها تلات أنواع
+
+261
+00:22:12,300 --> 00:22:16,120
+primary proliferative polycythemia و primary
+
+262
+00:22:16,120 --> 00:22:21,560
+thrombocythemia و ال myelofibrosis أيضاً رح نحكي
+
+263
+00:22:21,560 --> 00:22:26,460
+فيهم التلاتة و ال lymphoproliferative disorders
+
+264
+00:22:26,460 --> 00:22:30,700
+برضه بيندرج تحتها تلاتة multiple myeloma and
+
+265
+00:22:30,700 --> 00:22:36,340
+plasma cell disorders and non Hodgkin disease و
+
+266
+00:22:36,340 --> 00:22:41,560
+برضه هذه عبارة عن تلات أمثلة إن شاء الله احنا نتطرق
+
+267
+00:22:41,560 --> 00:22:46,900
+ليهم المقارنة في النهاية ما بين ال acute و ال
+
+268
+00:22:46,900 --> 00:22:52,480
+chronic تتمثل في جدول القاتل في ال age على سبيل
+
+269
+00:22:52,480 --> 00:22:55,640
+المثال ال acute تصيب كل الأعمار ال chronic بس
+
+270
+00:22:55,640 --> 00:23:01,960
+الأكبر طبعاً هذا مش exclusive يعني مش ايش مش
+
+271
+00:23:01,960 --> 00:23:08,140
+strict لكن بشكل عام clinical onset في ال acute
+
+272
+00:23:08,140 --> 00:23:11,880
+صدمة على طول بيجي المرض في ال chronic insidious
+
+273
+00:23:11,880 --> 00:23:17,480
+براحة وبالصدفة بنكتشفه leukemic cells في ال
+
+274
+00:23:17,480 --> 00:23:21,860
+acute ماتشوره بينما في ال chronic ماتشوره الأنيميا
+
+275
+00:23:21,860 --> 00:23:26,300
+في ال acute mild تصير بينما في ال chronic بيبقى
+
+276
+00:23:26,300 --> 00:23:31,400
+ال mild thrombocytopenia برضه في ال acute mild
+
+277
+00:23:31,400 --> 00:23:35,440
+تصير بينما في ال chronic mild
+
+278
+00:23:37,530 --> 00:23:42,510
+WBCs هي مختلفة في الأكيوت بينما دائماً تزداد
+
+279
+00:23:42,510 --> 00:23:49,270
+في الأكرونك والأورجان ميجالي طبعاً ليه هو غزو
+
+280
+00:23:49,270 --> 00:23:54,870
+الأعضاء الأخرى بالأكيوت مايلد لكن ما تلاقيه بالأكرونك 
+
+281
+00:23:54,870 --> 00:23:59,950
+dominant يعني دائم في الأورجان وميجالي للأعضاء
+
+282
+00:24:01,750 --> 00:24:06,750
+وبهيك بنكون أنا هنا أول محاضرة نرجو أن تكونوا قد
+
+283
+00:24:06,750 --> 00:24:08,470
+استمتعتوا  بها 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_postprocess.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..275d64ee54d0ede3c09eccf371dc3e54b5ce1731
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_postprocess.srt
@@ -0,0 +1,1132 @@
+1
+00:00:01,870 --> 00:00:04,910
+بسم الله الرحمن الرحيم والصلاة والسلام علي سيد
+
+2
+00:00:04,910 --> 00:00:11,290
+الخلق الأجمعين سيدنا محمد الصادق الأمين وبعد ننتقل
+
+3
+00:00:11,290 --> 00:00:15,570
+الآن إلى الجزء الثاني من المادة وهو ما يتعلق
+
+4
+00:00:15,570 --> 00:00:23,990
+بالأمراض ال white blood cell وطبعا أشهر هذه
+
+5
+00:00:23,990 --> 00:00:27,650
+الأمراض هي Malignancy of white blood cell او
+
+6
+00:00:27,650 --> 00:00:33,880
+Malignancy of Hemopoietic tissue وهيبالله كيميا
+
+7
+00:00:36,230 --> 00:00:43,070
+إضافة إلى إنه في تقسيمة هنتطلق إليها بتقسم هذه
+
+8
+00:00:43,070 --> 00:00:48,070
+الأمراض إلى خمس عائلات أساسية هنتقل إليها إن شاء
+
+9
+00:00:48,070 --> 00:00:52,590
+الله بالتفصيل إنما في هذه المحاضرة هنتعرف و هنتطلق
+
+10
+00:00:52,590 --> 00:00:57,930
+إلى المصطلحات القاتية نمر واحد ال definition ثم ال
+
+11
+00:00:57,930 --> 00:01:03,010
+historic perspective ثم أسبابها ال etiology and
+
+12
+00:01:03,010 --> 00:01:08,170
+risk factorsثم ال incidence و ال classification و
+
+13
+00:01:08,170 --> 00:01:11,770
+سنقارن في النهاية ما بين ال acute و ال chronic
+
+14
+00:01:11,770 --> 00:01:18,550
+leukemia ان شاء الله by
+
+15
+00:01:18,550 --> 00:01:23,170
+definition ال leukemia هي عبارة عن malignant
+
+16
+00:01:23,170 --> 00:01:26,950
+disease of hemopoietic tissue لماذا تتميز؟ كانت
+
+17
+00:01:26,950 --> 00:01:31,550
+تتميز by accumulation of abnormal white blood cell
+
+18
+00:01:31,550 --> 00:01:37,370
+في ال hemopoietic tissueوبيسموا الـ Abnormal White
+
+19
+00:01:37,370 --> 00:01:43,090
+Blood Cell بيعتوها لقب Neoplastic Cell أو Leukemic
+
+20
+00:01:43,090 --> 00:01:50,170
+Cellطبعا هذا الكلام هو بيتميز و بيزيد بيزيد في ال
+
+21
+00:01:50,170 --> 00:01:53,750
+hemopoietic tissue زي ما قلنا و طبعا ال major
+
+22
+00:01:53,750 --> 00:01:56,390
+hemopoietic tissue هي عبارة عن ال bone marrow
+
+23
+00:01:56,390 --> 00:02:03,390
+بيؤدي هذا الى ال bone marrow failure و أيضا يؤدي
+
+24
+00:02:03,390 --> 00:02:08,190
+الى زيادة في ال white blood cellوالحاجة التالتة
+
+25
+00:02:08,190 --> 00:02:12,330
+اللى بتقصاحب اللوكيميا هي ان الخلية السرطانية
+
+26
+00:02:12,330 --> 00:02:16,610
+بتغذو أعضاء الجسم المختلفة أشهرها ال liver و
+
+27
+00:02:16,610 --> 00:02:19,630
+الspleen و ال lymph nodes و الbrain
+
+28
+00:02:22,090 --> 00:02:26,330
+اللو كيميا الشغل الأولانية انه بيصير فيه raised في
+
+29
+00:02:26,330 --> 00:02:29,870
+ال circulating white blood cell يعني بيصير فيه
+
+30
+00:02:29,870 --> 00:02:34,550
+leukocytosis الحاجة التانية بيصير فيه monomalophia
+
+31
+00:02:34,550 --> 00:02:38,410
+فاحنا هنتعرف على هذا المصطلح ان شاء الله و الحاجة
+
+32
+00:02:38,410 --> 00:02:44,610
+التالتة infiltration of body organs المختلفة
+
+33
+00:02:44,800 --> 00:02:49,280
+Historic Perspective أول ما نحكي عن اللوكيميا هو
+
+34
+00:02:49,280 --> 00:02:56,160
+يوصفها في 1945 عالمين واحد في سكوتلاند اسمه penit
+
+35
+00:02:56,160 --> 00:03:04,200
+والتاني في جيرمانيا ال etiology and risk factor ال
+
+36
+00:03:04,200 --> 00:03:07,020
+etiology of اللوكيميا is unknown
+
+37
+00:03:09,270 --> 00:03:17,890
+It's unknown leukemia مرض من الأمراض التي لا يعرف
+
+38
+00:03:17,890 --> 00:03:22,830
+سببها وانت مافيه risk factor بتصاحب أو بتؤدي إلى
+
+39
+00:03:22,830 --> 00:03:28,250
+تكوين ال leukemia unknown ال leukemia unknown مرة
+
+40
+00:03:28,250 --> 00:03:35,470
+تانية الخلية سليمة في لحظة من اللحظات تقرر ان
+
+41
+00:03:35,470 --> 00:03:42,810
+تنقسم انقسامات غير طبيعيةالسبب انه يبدأ رب العباد
+
+42
+00:03:42,810 --> 00:03:48,930
+هو من يسير هذه الخلايا في لحظة من اللحظات ممكن اي
+
+43
+00:03:48,930 --> 00:03:53,810
+انسان يتعرض الى leukemia risk factor associated
+
+44
+00:03:53,810 --> 00:03:59,320
+with thatأول مره واحد انكوجين ميوتاشين and human
+
+45
+00:03:59,320 --> 00:04:04,260
+suppressor gene alteration واتنين هنتطلق الى موضوع
+
+46
+00:04:04,260 --> 00:04:07,940
+ال host factor وفي الآخر هنحكي على ال
+
+47
+00:04:07,940 --> 00:04:12,920
+environmental factor that increase the tendency of
+
+48
+00:04:12,920 --> 00:04:18,070
+leukemiaطبعا كل كنتش عارفين هذه الصورة هذه الصورة
+
+49
+00:04:18,070 --> 00:04:21,290
+هي عبارة عن ال hemopoietic tree هي ال stem cell
+
+50
+00:04:21,290 --> 00:04:26,610
+تنقسم وتدينا اما lymphoid واما myeloid ثم هذه
+
+51
+00:04:26,610 --> 00:04:31,370
+الخلايا تنقسم انقسامات مختلفة لغاية ما تصل ال
+
+52
+00:04:31,370 --> 00:04:42,350
+mature form في هذه المراحل ايه يتعرض لانقسامات
+
+53
+00:04:42,350 --> 00:04:48,860
+هذهأي خلل في الجينات المسؤول عن انتقال الخلية من
+
+54
+00:04:48,860 --> 00:04:53,360
+ال mature إلى ال mature form هذه عبارة عن جينات
+
+55
+00:04:53,360 --> 00:04:58,160
+تؤدي لانقسامات ماشي اي خلل في هذه الجينات يؤدي ال
+
+56
+00:04:58,160 --> 00:05:04,720
+الوكيميا اشتغل هذه ال mutation او ال gene
+
+57
+00:05:04,720 --> 00:05:09,160
+abnormality اللي هي ال oncogen mutation tumor
+
+58
+00:05:09,160 --> 00:05:14,120
+suppressor geneChromosomal abnormality and gene
+
+59
+00:05:14,120 --> 00:05:17,500
+rearrangement زي ما تشايفهم في أي مرحلة من المراحل
+
+60
+00:05:17,500 --> 00:05:22,700
+هذه الأسهم تؤدي أو تشير إلى المراحل المختلفة التي
+
+61
+00:05:22,700 --> 00:05:28,600
+تمر بها الغنية ما هو دور الجين او ال onco gene في
+
+62
+00:05:28,600 --> 00:05:32,660
+ال hemibiotic malignancy يعني ال human genome
+
+63
+00:05:32,660 --> 00:05:37,620
+بيتكون من جينات normally healthy gene بيسمى proto
+
+64
+00:05:37,620 --> 00:05:43,950
+onco gene and these genes code for proteinوهذه
+
+65
+00:05:43,950 --> 00:05:46,950
+البروتينة تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+66
+00:05:46,950 --> 00:05:47,450
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+67
+00:05:47,450 --> 00:05:49,370
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+68
+00:05:49,370 --> 00:05:52,310
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+69
+00:05:52,310 --> 00:05:58,990
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+70
+00:05:58,990 --> 00:06:05,050
+كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+71
+00:06:05,050 --> 00:06:12,830
+كشخصية أكتر تعمل كشخصية
+
+72
+00:06:12,830 --> 00:06:19,590
+أكترهذه الجينات ان اي خلال فيها يؤدي الى Malignant
+
+73
+00:06:19,590 --> 00:06:25,390
+Transformation الخلال
+
+74
+00:06:25,390 --> 00:06:32,090
+اللى سجله في هذه الجينات اللى غالبا مصحوب او موج
+
+75
+00:06:32,090 --> 00:06:35,730
+او ددق في الهيموبيوتك مالجنانسي لجوا اربعة نوع من
+
+76
+00:06:35,730 --> 00:06:40,570
+ال disorders translocation and inversion deletion
+
+77
+00:06:40,570 --> 00:06:45,220
+and numerical aberrationand point mutation و gene
+
+78
+00:06:45,220 --> 00:06:49,380
+amplification طيب
+
+79
+00:06:49,380 --> 00:06:56,860
+نيجي لل host factor نجي له ال host factor بيندرج
+
+80
+00:06:56,860 --> 00:07:02,220
+تحته القاتي congenital chromosome abnormality و
+
+81
+00:07:02,220 --> 00:07:10,240
+طبعا اي ناس اي مرضى عندهم زيادة في frequency of
+
+82
+00:07:10,240 --> 00:07:12,180
+congenital disorders
+
+83
+00:07:19,050 --> 00:07:25,210
+أشهر هذه الأمراض زي ال bloom syndrome طبعا عارفين
+
+84
+00:07:25,210 --> 00:07:30,040
+فانكوليزي أليمياDown syndrome climb filter
+
+85
+00:07:30,040 --> 00:07:32,280
+syndrome كلها عبارة عن أمراض أخدتها في ال
+
+86
+00:07:32,280 --> 00:07:37,440
+molecular ان شاء الله فهذه كلها عبارة عن أمراض
+
+87
+00:07:37,440 --> 00:07:44,460
+بيزيد فيها الكرمزوم ال aberration و instability of
+
+88
+00:07:44,460 --> 00:07:50,790
+chromosomeطبعا الناس هذولا وجدوا انه امكانية حدوث
+
+89
+00:07:50,790 --> 00:07:54,230
+ال acute leukemia عندهم بتزيد عن ال healthy people
+
+90
+00:07:54,230 --> 00:08:00,210
+او عن الناس اللي طبيعيين تمنتاشر لعشرين فرمية
+
+91
+00:08:00,210 --> 00:08:06,590
+تمنتاشر مرة لعشرين مرة زيادة في ال incidence of
+
+92
+00:08:06,590 --> 00:08:11,370
+acute leukemia عندهم عن الناس ال healthy وهذا
+
+93
+00:08:11,370 --> 00:08:16,170
+التحديد الإحصائي عملوه على ال down syndromeالحاجة
+
+94
+00:08:16,170 --> 00:08:21,270
+التانية ال Immunodeficiency يعني خلل أو نقص في
+
+95
+00:08:21,270 --> 00:08:27,600
+جهاز الملاعبوطبعا احنا بنعرف ان الجهاز المنهعة is
+
+96
+00:08:27,600 --> 00:08:32,660
+associated او مسئول من عنه اللي مسئول عنه ال B وT
+
+97
+00:08:32,660 --> 00:08:36,280
+lymphocyte وبالتالي اي خلل في ال gene
+
+98
+00:08:36,280 --> 00:08:40,540
+rearrangement of T وB lymphocyte هيؤدي الى
+
+99
+00:08:40,540 --> 00:08:44,600
+immunodeficiency status اشهر هذه الأمراض المصحوبة
+
+100
+00:08:44,600 --> 00:08:50,520
+بهذه الحالة هي التكسياتيليانجكتازيا six-linked
+
+101
+00:08:50,520 --> 00:08:51,880
+egamoglobulin
+
+102
+00:08:55,730 --> 00:08:59,710
+نمرة ثلاثة كرونك بومارو dysfunction من الاسم
+
+103
+00:08:59,710 --> 00:09:05,230
+dysfunction and chronic لمين للبومارو هذا هيزود ال
+
+104
+00:09:05,230 --> 00:09:10,230
+risk of acute leukemia وامثل على ذلك ال
+
+105
+00:09:10,230 --> 00:09:14,190
+myelodysplastic syndrome و ال myeloproniferative
+
+106
+00:09:14,190 --> 00:09:22,150
+disorders aplastic anemia and PIH هنتطرق للمصطلحات
+
+107
+00:09:22,150 --> 00:09:27,540
+تجلجوشالسبب الأخير هو ال environmental factor أو
+
+108
+00:09:27,540 --> 00:09:32,220
+العنوان الأخير ال environmental يعني اتعرض الإنسان
+
+109
+00:09:32,220 --> 00:09:35,680
+لبيئة غير طبيعية من أشهر هذه البيئات الغير طبيعية
+
+110
+00:09:35,680 --> 00:09:40,420
+ionizing radiation و كنا شوفنا شو صار في اليابان
+
+111
+00:09:40,420 --> 00:09:45,360
+في لما طبعا
+
+112
+00:09:45,360 --> 00:09:51,240
+اتعرضوا إلى ال Hiroshima Nagasaki bomb او نيكليار
+
+113
+00:09:51,240 --> 00:09:57,110
+بوم في Hiroshima و Nagasakiو شو صار في العراق و
+
+114
+00:09:57,110 --> 00:10:02,410
+حتى شو صار في بلادنا طبعا هذه كلها عبارة عن ان ال
+
+115
+00:10:02,410 --> 00:10:06,230
+ionizing radiation is associated with acute and
+
+116
+00:10:06,230 --> 00:10:11,610
+chronic leukemia سجلة حالات في بعدها في كل أنواع
+
+117
+00:10:11,610 --> 00:10:16,850
+ال leukemia ايضا سجلة حالات في ال lymphoma
+
+118
+00:10:16,850 --> 00:10:24,150
+وبالتالي كل أنواع ال leukemia سجلة فيها ال ELLاللي
+
+119
+00:10:24,150 --> 00:10:27,390
+هو acute myelogenous leukemia acute lymphoplastic
+
+120
+00:10:27,390 --> 00:10:30,910
+leukemia chronic myelogenous leukemia كلها عبارة
+
+121
+00:10:30,910 --> 00:10:41,030
+عن حالات سجلت drugs أيضا سجلت حالات من ال leukemic
+
+122
+00:10:41,030 --> 00:10:48,460
+transformation associated with drugطبعا أشهر هذه
+
+123
+00:10:48,460 --> 00:10:52,560
+ال drugs هو ال benzine, chloraphenicol,
+
+124
+00:10:52,660 --> 00:10:55,780
+renalputazone, and cytotoxic alkylating
+
+125
+00:10:55,780 --> 00:11:00,100
+chemotherapeutic agents الناس اللي بتاخدوا كيماوي
+
+126
+00:11:00,100 --> 00:11:04,680
+شو بعمل الكيماوي؟ قالوا الكيماوي هو أو ال
+
+127
+00:11:04,680 --> 00:11:08,700
+cytotoxic alkylating chemotherapeutic agent هو
+
+128
+00:11:08,700 --> 00:11:12,200
+عبارة عن strongly electrophilic agents
+
+129
+00:11:14,530 --> 00:11:19,050
+بتطبق نيكلوفيليكسايت على ال DNA نيكلوفيليكسايت
+
+130
+00:11:19,050 --> 00:11:27,230
+يعني نيكليكسايت
+
+131
+00:11:27,230 --> 00:11:31,530
+نيكليكسايت نيكليكسايت
+
+132
+00:11:31,530 --> 00:11:35,130
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+133
+00:11:35,130 --> 00:11:35,970
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+134
+00:11:35,970 --> 00:11:38,470
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+135
+00:11:38,470 --> 00:11:40,350
+نيكليكسايت
+
+136
+00:11:44,870 --> 00:11:50,350
+بيأتي لـ strand breaks , complex , rearrangement
+
+137
+00:11:50,350 --> 00:11:53,950
+بيأتي لـ deletion of part or all of the chromosome
+
+138
+00:11:53,950 --> 00:11:59,490
+شوف الفرق بينها، بين اللوكيميا اللي بتنتج عنالـ
+
+139
+00:11:59,490 --> 00:12:01,730
+chemotherapy يعني الـ therapy induced و بين
+
+140
+00:12:01,730 --> 00:12:05,770
+اللوكيميا الأصلية قالوا في تلات فروقات أساسية
+
+141
+00:12:05,770 --> 00:12:12,750
+الفرق الأول يعني في ال therapy induced acute non
+
+142
+00:12:12,750 --> 00:12:17,730
+lymphoplastic لوكيميا cases تسعين فالمية من
+
+143
+00:12:17,730 --> 00:12:21,570
+الحالات عندهم chromosomal cytogenetic abnormality
+
+144
+00:12:23,610 --> 00:12:26,850
+أشهر هذه الـ cytogenetic abnormality أو الكرمزوم
+
+145
+00:12:26,850 --> 00:12:32,010
+الابنورمالي هو الـ monosomy 5, 5Q-, monosomy 7,
+
+146
+00:12:32,150 --> 00:12:37,790
+and 7Q-, بينما أقل من 60% في الدنوهو الدنوهو يعني
+
+147
+00:12:37,790 --> 00:12:41,670
+الأصلية cases
+
+148
+00:12:41,670 --> 00:12:46,610
+عندهم cytogenetic abnormality و كرمزوم رقم خمسة
+
+149
+00:12:46,610 --> 00:12:55,940
+وسبعة usually are involved less commonlyالسبب
+
+150
+00:12:55,940 --> 00:13:00,040
+التاني او العامل التلفارق التاني هو اكتر من تلتين
+
+151
+00:13:00,040 --> 00:13:05,660
+حالات ثلاث بإنهيوس لوكيميا غالبا بيسبقها مرحلة
+
+152
+00:13:05,660 --> 00:13:11,690
+بيسموها pre-lokemic phase وفي هذه المرحلةاللي
+
+153
+00:13:11,690 --> 00:13:16,310
+بيكون فيه severe dysplastic changes و ineffective
+
+154
+00:13:16,310 --> 00:13:20,750
+hemopoiesis انت يعني مايعرفش يعني ineffective
+
+155
+00:13:20,750 --> 00:13:27,990
+hemopoiesis يعني premature cell death and in de
+
+156
+00:13:27,990 --> 00:13:34,630
+novo ال pre leukemic states او phase بيحدث في اقل
+
+157
+00:13:34,630 --> 00:13:39,320
+من الرابع هناك التلتين اقل من الرابعالفرق التالت
+
+158
+00:13:39,320 --> 00:13:42,920
+ال therapy induced is a refractory treatment و
+
+159
+00:13:42,920 --> 00:13:47,260
+المريض مايعيش أكتر من أربع شهور بينما ال donovo
+
+160
+00:13:47,260 --> 00:13:49,380
+ممكن يعيش عشرين شهر
+
+161
+00:13:53,230 --> 00:13:57,470
+النقطة التانية هي ال chemicals و يقولنا تعرض
+
+162
+00:13:57,470 --> 00:14:00,330
+الإنسان إلى chemicals زي المنزين زي ال cigarette
+
+163
+00:14:00,330 --> 00:14:05,310
+smokers زي المزارعين اللي بتعرضوا للمبيدات الحشرية
+
+164
+00:14:05,310 --> 00:14:11,650
+زي ال rubber industry workers زي حتى أطفال عاملين
+
+165
+00:14:11,650 --> 00:14:13,970
+في ال industry workers
+
+166
+00:14:17,690 --> 00:14:28,290
+والناس اللى مخدرين الاناستيزيا ايضا بيتعرض الفيروس
+
+167
+00:14:28,290 --> 00:14:37,370
+سجلت حالاتكثيرة طبعا associated with leukemia أشهر
+
+168
+00:14:37,370 --> 00:14:40,890
+هذه الحالات أمثل عليها هي human T cell leukemia
+
+169
+00:14:40,890 --> 00:14:47,290
+الفيروس واحد وجدوه هو عبارة عن causative agent لل
+
+170
+00:14:47,290 --> 00:14:54,530
+other T cell leukemia و ال HTLV2 وجدوه في atypical
+
+171
+00:14:54,530 --> 00:14:57,510
+heresy اللوكيمي و يعني هو من أنواع chronic
+
+172
+00:14:57,510 --> 00:14:59,150
+lymphocytic leukemia
+
+173
+00:15:02,600 --> 00:15:07,900
+موجود في البركتس الفومة و أول ما اكتشفوا هذه
+
+174
+00:15:07,900 --> 00:15:11,220
+الشغلات كانوا بيعتبروها الـ causative agent يعني
+
+175
+00:15:11,220 --> 00:15:15,600
+المسبب الأساسي لللو كيميا هي عبارة عن ال virus
+
+176
+00:15:15,600 --> 00:15:18,700
+incidence
+
+177
+00:15:18,700 --> 00:15:23,460
+ال overall incidence لللو كيميا هي تمانية العشر
+
+178
+00:15:23,460 --> 00:15:29,640
+حلوات لكل مئة ألف من ال population سنويًا يعني في
+
+179
+00:15:29,640 --> 00:15:38,450
+بلادنا فيه2 مليون يعني فعلا من 160 حالة إلى 200
+
+180
+00:15:38,450 --> 00:15:45,390
+حالة سنوي في غزة او في قطاع غزة نص هذه الحالات
+
+181
+00:15:45,390 --> 00:15:51,190
+acute و نص الداني chronic ولو كيميا بشكل عام تصيب
+
+182
+00:15:51,190 --> 00:15:57,390
+ال adult أكتر من الأطفال بالنسبة عشرة إلى واحد
+
+183
+00:15:58,880 --> 00:16:05,420
+وغالبا ال male أكتر من ال female بنسبة 1 إلى 2 إلى
+
+184
+00:16:05,420 --> 00:16:09,340
+1 بشكل
+
+185
+00:16:09,340 --> 00:16:12,880
+عام اللوكيميا بتسيب كل الأعمار لكن وجدوا ان ال
+
+186
+00:16:12,880 --> 00:16:17,180
+acute lymphoplastic لوكيميا بتسيب الأطفال بينما ال
+
+187
+00:16:17,180 --> 00:16:22,560
+acute myelogenous لوكيميا بتسيب الأكبر 75% من
+
+188
+00:16:22,560 --> 00:16:25,980
+حالات ال childhood لوكيميا هي عبارة عن acute
+
+189
+00:16:25,980 --> 00:16:30,550
+lymphoplastic لوكيميابينما 80% من حالة الـ Acute
+
+190
+00:16:30,550 --> 00:16:34,550
+Myelogenous Leukemia بتشوفها فى دكتورة ال chronic
+
+191
+00:16:34,550 --> 00:16:39,150
+leukemia بشكل عام هي عبارة عن disease of adult
+
+192
+00:16:39,150 --> 00:16:45,070
+chronic lymphocytic leukemiaخصوصاً في الاطفال
+
+193
+00:16:45,070 --> 00:16:53,350
+وغالباً ما نشاهدها قبل سن الأربعين الويلوجنس
+
+194
+00:16:53,350 --> 00:16:55,570
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+195
+00:16:55,570 --> 00:17:02,050
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+196
+00:17:02,050 --> 00:17:02,350
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+197
+00:17:02,350 --> 00:17:02,970
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+198
+00:17:02,970 --> 00:17:04,570
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+199
+00:17:04,570 --> 00:17:12,510
+الوكيميا الوكيميا الوفهذه تقسيمة بشكل عام للاطفال
+
+200
+00:17:12,510 --> 00:17:17,470
+in terms of ال leukemia classification of leukemia
+
+201
+00:17:17,470 --> 00:17:23,870
+قسموها الى acute و chronic ويقسم ال acute الى
+
+202
+00:17:23,870 --> 00:17:27,690
+myeloid
+
+203
+00:17:27,690 --> 00:17:31,960
+و lymphoid حسب نوع الخليةو جاروا الـ Myeloid عبارة
+
+204
+00:17:31,960 --> 00:17:38,520
+عن تمان أنواع و اعطوها رمز M من Myeloid أول حرف من
+
+205
+00:17:38,520 --> 00:17:43,340
+Myeloid و باقنها تمان أنواع دوها عرقاب شهولة الـH
+
+206
+00:17:43,340 --> 00:17:50,220
+التفريق في M0, M1, M2 لغاية M7 بينما ال Limfoid
+
+207
+00:17:50,220 --> 00:17:56,880
+اعطوها أول حرف من Limfoid وهو Lفصار في عندنا acute
+
+208
+00:17:56,880 --> 00:17:59,860
+lymphoplastic leukemia و acute myelogenous
+
+209
+00:17:59,860 --> 00:18:03,620
+leukemia و جالوا ال acute lymphoplastic تلت أنواع
+
+210
+00:18:03,620 --> 00:18:08,420
+الواحد والاتنين والتلت ايضا ال chronic leukemia
+
+211
+00:18:08,420 --> 00:18:12,940
+according to the type of cells involved جالو هي
+
+212
+00:18:12,940 --> 00:18:16,780
+عبارة عن myeloid و lymphoid فأشهر أنواع ال myeloid
+
+213
+00:18:16,780 --> 00:18:20,860
+هي chronic myelogenous leukemia بينما ال lymphoid
+
+214
+00:18:20,860 --> 00:18:24,980
+يندرج تحتها اكتر من نوعزي ال chronic lymphocytic
+
+215
+00:18:24,980 --> 00:18:29,400
+leukemia برو lymphocytic leukemia هيريسل leukemia
+
+216
+00:18:29,400 --> 00:18:35,180
+هتترخ ليه كل هذه الأنواع ان شاء الله نهاية ال
+
+217
+00:18:35,180 --> 00:18:41,580
+course زي ما قلتلكوا قسموا ال leukemia لخمس عائلات
+
+218
+00:18:41,580 --> 00:18:47,860
+أساسية كل العائلة هي ال acute leukemia ثم ال
+
+219
+00:18:47,860 --> 00:18:56,310
+chronic leukemiaميلو ديس بلاستيك سندروه ميلو ديس
+
+220
+00:18:56,310 --> 00:19:05,210
+بلاستيك
+
+221
+00:19:05,210 --> 00:19:11,740
+سندروه ميلو ديس بلاستيك سندروهعائلة أخرى برد واحد
+
+222
+00:19:11,740 --> 00:19:15,280
+نيجي إيها بالتفصيل ثم non-leukemic
+
+223
+00:19:15,280 --> 00:19:19,960
+myeloproliferative disorders هي مش leukemia لكن في
+
+224
+00:19:19,960 --> 00:19:25,500
+proliferative يعني high proliferative capacity ثم
+
+225
+00:19:25,500 --> 00:19:29,140
+non-leukemic lymphoproliferative disorders
+
+226
+00:19:29,140 --> 00:19:32,760
+according to the cell type either مقسمها إلى نوعين
+
+227
+00:19:32,760 --> 00:19:38,760
+الmyeloid و ال lymphoidفهي خمس عائلات أساسية ان
+
+228
+00:19:38,760 --> 00:19:43,800
+شاء الله احنا نتفرق لكل هذه الأنواع بالتفصيل بشكل
+
+229
+00:19:43,800 --> 00:19:46,160
+عام الأكيد اللوكيميا by definition هي بره عن
+
+230
+00:19:46,160 --> 00:19:50,300
+اللوكيميا اللي بتتميز ب uncontrolled proliferation
+
+231
+00:19:50,300 --> 00:19:54,920
+of poorly differentiated cells ايش يعني poorly
+
+232
+00:19:54,920 --> 00:19:59,800
+differentiated يعني اللي لسه مش ناجة ال immature
+
+233
+00:19:59,800 --> 00:20:06,930
+cell بيسموها في هذه الحالة blast cellفالـ Leukemia
+
+234
+00:20:06,930 --> 00:20:10,810
+لكن الـ Acute Leukemia بتتميز بزيادة في عدد إيش
+
+235
+00:20:10,810 --> 00:20:15,850
+لبلاسل وقسموها لنوعين according to the predominant
+
+236
+00:20:15,850 --> 00:20:20,770
+cell lineage إلى Acute lymphoplastic و Acute non
+
+237
+00:20:20,770 --> 00:20:24,050
+lymphoplastic leukemia أو بيسموها Acute
+
+238
+00:20:24,050 --> 00:20:28,310
+myelogenous leukemia و هذه التقسيمة اللي حاكينا
+
+239
+00:20:28,310 --> 00:20:33,190
+عليها الـ Acute myeloid و الـ non myeloid
+
+240
+00:20:35,230 --> 00:20:40,670
+وقلنا ال AML هي تمان أنواع وال ALL هي تلات أنواع
+
+241
+00:20:40,670 --> 00:20:45,010
+ال chronic leukemia بتختلف عن ال acute leukemia ان
+
+242
+00:20:45,010 --> 00:20:50,530
+الخلايا الموجود المصابة فيها هي عبارة عن خلايا
+
+243
+00:20:50,530 --> 00:20:55,900
+تقريبا matureماشي some characteristic of maturity
+
+244
+00:20:55,900 --> 00:21:00,080
+بتكون واضحة جدا في ال chronic leukemia وفي أنواع
+
+245
+00:21:00,080 --> 00:21:03,580
+كثيرة زى ما قلنا هتتطلعق ليها chronic lymphocytic
+
+246
+00:21:03,580 --> 00:21:06,740
+leukemia, pro lymphocytic leukemia, heresy
+
+247
+00:21:06,740 --> 00:21:11,100
+leukemia and CML أو chronic myeloid leukemia
+
+248
+00:21:13,060 --> 00:21:16,900
+myelodysplastic syndrome عرفوها في البداية هي
+
+249
+00:21:16,900 --> 00:21:21,040
+عبارة عن الـ leukemic condition يعني حالة بتسبق
+
+250
+00:21:21,040 --> 00:21:25,840
+اللوكيميا يعني مرض من هالنوع بيجلب للوكيميا قسموه
+
+251
+00:21:25,840 --> 00:21:30,760
+according to the FAB ايه ال criteria FAB يا جماعة
+
+252
+00:21:30,760 --> 00:21:35,240
+الخير اختصار ل French American British scientist
+
+253
+00:21:35,240 --> 00:21:41,550
+مجموعة من العلماء الامريكان والبريطانيوالفرنسيين
+
+254
+00:21:41,550 --> 00:21:44,510
+جلسوا وعملوا Classification لكل أنواع اللوكيميا
+
+255
+00:21:44,510 --> 00:21:48,930
+قالوا انا خمس أنواع Refractory Anemia Refractory
+
+256
+00:21:48,930 --> 00:21:52,350
+Anemia with Excess Plast Refractory Anemia with
+
+257
+00:21:52,350 --> 00:21:56,370
+Excess Plast ثم Refractory Anemia with Excess
+
+258
+00:21:56,370 --> 00:21:59,170
+Plast and Transformation and Chronic
+
+259
+00:21:59,170 --> 00:22:06,130
+Myelomonasitic Lokemia وسبب ان ان اللوكيميك غالفة
+
+260
+00:22:06,130 --> 00:22:12,300
+ال disorder قسموها لنوعينبيندرج تحتها تلت أنواع
+
+261
+00:22:12,300 --> 00:22:16,120
+primary proliferative polycythemia و primary
+
+262
+00:22:16,120 --> 00:22:21,560
+thrombocythemia و ال myelofibrosis أيضا رح نحكي
+
+263
+00:22:21,560 --> 00:22:26,460
+فيهم التلاتة و ال lymphoproliferative disorders
+
+264
+00:22:26,460 --> 00:22:30,700
+برضه بيندرج تحتها تلاتة multiple myeloma and
+
+265
+00:22:30,700 --> 00:22:36,340
+plasma cell disorders and non Hodgkin disease و
+
+266
+00:22:36,340 --> 00:22:41,560
+برضه هذه عبارة عنتلت امثلا شاء الله احنا نتطرق
+
+267
+00:22:41,560 --> 00:22:46,900
+ديهم المقارنة في النهاية ما بين ال acute و ال
+
+268
+00:22:46,900 --> 00:22:52,480
+chronic تتمثل من جدول القاتل ف ال age على سبيل
+
+269
+00:22:52,480 --> 00:22:55,640
+المثال ال acute تصيب كل الأعمار ال chronic بس
+
+270
+00:22:55,640 --> 00:23:01,960
+الأضاءة طبعا هذا مش exclusive يعني مش ايش مش
+
+271
+00:23:01,960 --> 00:23:08,140
+strict لكن بشكل عامclinical onset في الـ acute
+
+272
+00:23:08,140 --> 00:23:11,880
+صدمة على طول بيجي المرض في الـ chronic insidious
+
+273
+00:23:11,880 --> 00:23:17,480
+براحة و بالصدفة بنكتشفه leukemic cells في الـ
+
+274
+00:23:17,480 --> 00:23:21,860
+acute ماتشور بينما في الـ chronic ماتشور الأنيميا
+
+275
+00:23:21,860 --> 00:23:26,300
+في الـ acute mild تسير بينما في الـ chronic بيبقى
+
+276
+00:23:26,300 --> 00:23:31,400
+الـ mild thrombocytopenia برضه في الـ acute mild
+
+277
+00:23:31,400 --> 00:23:35,440
+تسير بينما في الـ chronic mild
+
+278
+00:23:37,530 --> 00:23:42,510
+Y-species هي مختلفة في الأكيوت بينما دائما تزداد
+
+279
+00:23:42,510 --> 00:23:49,270
+في الأكرونك والأورجان وميجالي طبعا ليه هو غزو
+
+280
+00:23:49,270 --> 00:23:54,870
+الأعضاء الأخرى بالأكيوت مايلد لكن ملاقاش بالأكرونك
+
+281
+00:23:54,870 --> 00:23:59,950
+dominant يعني دائم في أورجان وميجالي للأعضاء
+
+282
+00:24:01,750 --> 00:24:06,750
+وبهيك بنكون أنا هنا أول محاضرة نرجو أن تكونوا قد
+
+283
+00:24:06,750 --> 00:24:08,470
+استمتعتوا معناه
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b876de55972f3448a7ff017f248d3d2ac4507059
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/rHjgzCkQZ8o_raw.srt
@@ -0,0 +1,1148 @@
+1
+00:00:01,870 --> 00:00:04,910
+بسم الله الرحمن الرحيم والصلاة والسلام علي سيد
+
+2
+00:00:04,910 --> 00:00:11,290
+الخلق الأجمعين سيدنا محمد الصادق الأمين وبعد ننتقل
+
+3
+00:00:11,290 --> 00:00:15,570
+الآن إلى الجزء الثاني من المادة وهو ما يتعلق
+
+4
+00:00:15,570 --> 00:00:23,990
+بالأمراض ال white blood cell وطبعا أشهر هذه
+
+5
+00:00:23,990 --> 00:00:27,650
+الأمراض هي Malignancy of white blood cell او
+
+6
+00:00:27,650 --> 00:00:33,880
+Malignancy of Hemopoietic tissue وهيبالله كيميا
+
+7
+00:00:36,230 --> 00:00:43,070
+إضافة إلى إنه في تقسيمة هنتطلق إليها بتقسم هذه
+
+8
+00:00:43,070 --> 00:00:48,070
+الأمراض إلى خمس عائلات أساسية هنتقل إليها إن شاء
+
+9
+00:00:48,070 --> 00:00:52,590
+الله بالتفصيل إنما في هذه المحاضرة هنتعرف و هنتطلق
+
+10
+00:00:52,590 --> 00:00:57,930
+إلى المصطلحات القاتية نمر واحد ال definition ثم ال
+
+11
+00:00:57,930 --> 00:01:03,010
+historic perspective ثم أسبابها ال etiology and
+
+12
+00:01:03,010 --> 00:01:08,170
+risk factorsثم ال incidence و ال classification و
+
+13
+00:01:08,170 --> 00:01:11,770
+سنقارن في النهاية ما بين ال acute و ال chronic
+
+14
+00:01:11,770 --> 00:01:18,550
+leukemia ان شاء الله by
+
+15
+00:01:18,550 --> 00:01:23,170
+definition ال leukemia هي عبارة عن malignant
+
+16
+00:01:23,170 --> 00:01:26,950
+disease of hemopoietic tissue لماذا تتميز؟ كانت
+
+17
+00:01:26,950 --> 00:01:31,550
+تتميز by accumulation of abnormal white blood cell
+
+18
+00:01:31,550 --> 00:01:37,370
+في ال hemopoietic tissueوبيسموا الـ Abnormal White
+
+19
+00:01:37,370 --> 00:01:43,090
+Blood Cell بيعتوها لقب Neoplastic Cell أو Leukemic
+
+20
+00:01:43,090 --> 00:01:50,170
+Cellطبعا هذا الكلام هو بيتميز و بيزيد بيزيد في ال
+
+21
+00:01:50,170 --> 00:01:53,750
+hemopoietic tissue زي ما قلنا و طبعا ال major
+
+22
+00:01:53,750 --> 00:01:56,390
+hemopoietic tissue هي عبارة عن ال bone marrow
+
+23
+00:01:56,390 --> 00:02:03,390
+بيؤدي هذا الى ال bone marrow failure و أيضا يؤدي
+
+24
+00:02:03,390 --> 00:02:08,190
+الى زيادة في ال white blood cellوالحاجة التالتة
+
+25
+00:02:08,190 --> 00:02:12,330
+اللى بتقصاحب اللوكيميا هي ان الخلية السرطانية
+
+26
+00:02:12,330 --> 00:02:16,610
+بتغذو أعضاء الجسم المختلفة أشهرها ال liver و
+
+27
+00:02:16,610 --> 00:02:19,630
+الspleen و ال lymph nodes و الbrain
+
+28
+00:02:22,090 --> 00:02:26,330
+اللو كيميا الشغل الأولانية انه بيصير فيه raised في
+
+29
+00:02:26,330 --> 00:02:29,870
+ال circulating white blood cell يعني بيصير فيه
+
+30
+00:02:29,870 --> 00:02:34,550
+leukocytosis الحاجة التانية بيصير فيه monomalophia
+
+31
+00:02:34,550 --> 00:02:38,410
+فاحنا هنتعرف على هذا المصطلح ان شاء الله و الحاجة
+
+32
+00:02:38,410 --> 00:02:44,610
+التالتة infiltration of body organs المختلفة
+
+33
+00:02:44,800 --> 00:02:49,280
+Historic Perspective أول ما نحكي عن اللوكيميا هو
+
+34
+00:02:49,280 --> 00:02:56,160
+يوصفها في 1945 عالمين واحد في سكوتلاند اسمه penit
+
+35
+00:02:56,160 --> 00:03:04,200
+والتاني في جيرمانيا ال etiology and risk factor ال
+
+36
+00:03:04,200 --> 00:03:07,020
+etiology of اللوكيميا is unknown
+
+37
+00:03:09,270 --> 00:03:17,890
+It's unknown leukemia مرض من الأمراض التي لا يعرف
+
+38
+00:03:17,890 --> 00:03:22,830
+سببها وانت مافيه risk factor بتصاحب أو بتؤدي إلى
+
+39
+00:03:22,830 --> 00:03:28,250
+تكوين ال leukemia unknown ال leukemia unknown مرة
+
+40
+00:03:28,250 --> 00:03:35,470
+تانية الخلية سليمة في لحظة من اللحظات تقرر ان
+
+41
+00:03:35,470 --> 00:03:42,810
+تنقسم انقسامات غير طبيعيةالسبب انه يبدأ رب العباد
+
+42
+00:03:42,810 --> 00:03:48,930
+هو من يسير هذه الخلايا في لحظة من اللحظات ممكن اي
+
+43
+00:03:48,930 --> 00:03:53,810
+انسان يتعرض الى leukemia risk factor associated
+
+44
+00:03:53,810 --> 00:03:59,320
+with thatأول مره واحد انكوجين ميوتاشين and human
+
+45
+00:03:59,320 --> 00:04:04,260
+suppressor gene alteration واتنين هنتطلق الى موضوع
+
+46
+00:04:04,260 --> 00:04:07,940
+ال host factor وفي الآخر هنحكي على ال
+
+47
+00:04:07,940 --> 00:04:12,920
+environmental factor that increase the tendency of
+
+48
+00:04:12,920 --> 00:04:18,070
+leukemiaطبعا كل كنتش عارفين هذه الصورة هذه الصورة
+
+49
+00:04:18,070 --> 00:04:21,290
+هي عبارة عن ال hemopoietic tree هي ال stem cell
+
+50
+00:04:21,290 --> 00:04:26,610
+تنقسم وتدينا اما lymphoid واما myeloid ثم هذه
+
+51
+00:04:26,610 --> 00:04:31,370
+الخلايا تنقسم انقسامات مختلفة لغاية ما تصل ال
+
+52
+00:04:31,370 --> 00:04:42,350
+mature form في هذه المراحل ايه يتعرض لانقسامات
+
+53
+00:04:42,350 --> 00:04:48,860
+هذهأي خلل في الجينات المسؤول عن انتقال الخلية من
+
+54
+00:04:48,860 --> 00:04:53,360
+ال mature إلى ال mature form هذه عبارة عن جينات
+
+55
+00:04:53,360 --> 00:04:58,160
+تؤدي لانقسامات ماشي اي خلل في هذه الجينات يؤدي ال
+
+56
+00:04:58,160 --> 00:05:04,720
+الوكيميا اشتغل هذه ال mutation او ال gene
+
+57
+00:05:04,720 --> 00:05:09,160
+abnormality اللي هي ال oncogen mutation tumor
+
+58
+00:05:09,160 --> 00:05:14,120
+suppressor geneChromosomal abnormality and gene
+
+59
+00:05:14,120 --> 00:05:17,500
+rearrangement زي ما تشايفهم في أي مرحلة من المراحل
+
+60
+00:05:17,500 --> 00:05:22,700
+هذه الأسهم تؤدي أو تشير إلى المراحل المختلفة التي
+
+61
+00:05:22,700 --> 00:05:28,600
+تمر بها الغنية ما هو دور الجين او ال onco gene في
+
+62
+00:05:28,600 --> 00:05:32,660
+ال hemibiotic malignancy يعني ال human genome
+
+63
+00:05:32,660 --> 00:05:37,620
+بيتكون من جينات normally healthy gene بيسمى proto
+
+64
+00:05:37,620 --> 00:05:43,950
+onco gene and these genes code for proteinوهذه
+
+65
+00:05:43,950 --> 00:05:46,950
+البروتينة تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+66
+00:05:46,950 --> 00:05:47,450
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+67
+00:05:47,450 --> 00:05:49,370
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+68
+00:05:49,370 --> 00:05:52,310
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+69
+00:05:52,310 --> 00:05:58,990
+كشخصية أكتر تعمل كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+70
+00:05:58,990 --> 00:06:05,050
+كشخصية أكتر تعمل كشخصية أكتر تعمل
+
+71
+00:06:05,050 --> 00:06:12,830
+كشخصية أكتر تعمل كشخصية
+
+72
+00:06:12,830 --> 00:06:19,590
+أكترهذه الجينات ان اي خلال فيها يؤدي الى Malignant
+
+73
+00:06:19,590 --> 00:06:25,390
+Transformation الخلال
+
+74
+00:06:25,390 --> 00:06:32,090
+اللى سجله في هذه الجينات اللى غالبا مصحوب او موج
+
+75
+00:06:32,090 --> 00:06:35,730
+او ددق في الهيموبيوتك مالجنانسي لجوا اربعة نوع من
+
+76
+00:06:35,730 --> 00:06:40,570
+ال disorders translocation and inversion deletion
+
+77
+00:06:40,570 --> 00:06:45,220
+and numerical aberrationand point mutation و gene
+
+78
+00:06:45,220 --> 00:06:49,380
+amplification طيب
+
+79
+00:06:49,380 --> 00:06:56,860
+نيجي لل host factor نجي له ال host factor بيندرج
+
+80
+00:06:56,860 --> 00:07:02,220
+تحته القاتي congenital chromosome abnormality و
+
+81
+00:07:02,220 --> 00:07:10,240
+طبعا اي ناس اي مرضى عندهم زيادة في frequency of
+
+82
+00:07:10,240 --> 00:07:12,180
+congenital disorders
+
+83
+00:07:19,050 --> 00:07:25,210
+أشهر هذه الأمراض زي ال bloom syndrome طبعا عارفين
+
+84
+00:07:25,210 --> 00:07:30,040
+فانكوليزي أليمياDown syndrome climb filter
+
+85
+00:07:30,040 --> 00:07:32,280
+syndrome كلها عبارة عن أمراض أخدتها في ال
+
+86
+00:07:32,280 --> 00:07:37,440
+molecular ان شاء الله فهذه كلها عبارة عن أمراض
+
+87
+00:07:37,440 --> 00:07:44,460
+بيزيد فيها الكرمزوم ال aberration و instability of
+
+88
+00:07:44,460 --> 00:07:50,790
+chromosomeطبعا الناس هذولا وجدوا انه امكانية حدوث
+
+89
+00:07:50,790 --> 00:07:54,230
+ال acute leukemia عندهم بتزيد عن ال healthy people
+
+90
+00:07:54,230 --> 00:08:00,210
+او عن الناس اللي طبيعيين تمنتاشر لعشرين فرمية
+
+91
+00:08:00,210 --> 00:08:06,590
+تمنتاشر مرة لعشرين مرة زيادة في ال incidence of
+
+92
+00:08:06,590 --> 00:08:11,370
+acute leukemia عندهم عن الناس ال healthy وهذا
+
+93
+00:08:11,370 --> 00:08:16,170
+التحديد الإحصائي عملوه على ال down syndromeالحاجة
+
+94
+00:08:16,170 --> 00:08:21,270
+التانية ال Immunodeficiency يعني خلل أو نقص في
+
+95
+00:08:21,270 --> 00:08:27,600
+جهاز الملاعبوطبعا احنا بنعرف ان الجهاز المنهعة is
+
+96
+00:08:27,600 --> 00:08:32,660
+associated او مسئول من عنه اللي مسئول عنه ال B وT
+
+97
+00:08:32,660 --> 00:08:36,280
+lymphocyte وبالتالي اي خلل في ال gene
+
+98
+00:08:36,280 --> 00:08:40,540
+rearrangement of T وB lymphocyte هيؤدي الى
+
+99
+00:08:40,540 --> 00:08:44,600
+immunodeficiency status اشهر هذه الأمراض المصحوبة
+
+100
+00:08:44,600 --> 00:08:50,520
+بهذه الحالة هي التكسياتيليانجكتازيا six-linked
+
+101
+00:08:50,520 --> 00:08:51,880
+egamoglobulin
+
+102
+00:08:55,730 --> 00:08:59,710
+نمرة ثلاثة كرونك بومارو dysfunction من الاسم
+
+103
+00:08:59,710 --> 00:09:05,230
+dysfunction and chronic لمين للبومارو هذا هيزود ال
+
+104
+00:09:05,230 --> 00:09:10,230
+risk of acute leukemia وامثل على ذلك ال
+
+105
+00:09:10,230 --> 00:09:14,190
+myelodysplastic syndrome و ال myeloproniferative
+
+106
+00:09:14,190 --> 00:09:22,150
+disorders aplastic anemia and PIH هنتطرق للمصطلحات
+
+107
+00:09:22,150 --> 00:09:27,540
+تجلجوشالسبب الأخير هو ال environmental factor أو
+
+108
+00:09:27,540 --> 00:09:32,220
+العنوان الأخير ال environmental يعني اتعرض الإنسان
+
+109
+00:09:32,220 --> 00:09:35,680
+لبيئة غير طبيعية من أشهر هذه البيئات الغير طبيعية
+
+110
+00:09:35,680 --> 00:09:40,420
+ionizing radiation و كنا شوفنا شو صار في اليابان
+
+111
+00:09:40,420 --> 00:09:45,360
+في لما طبعا
+
+112
+00:09:45,360 --> 00:09:51,240
+اتعرضوا إلى ال Hiroshima Nagasaki bomb او نيكليار
+
+113
+00:09:51,240 --> 00:09:57,110
+بوم في Hiroshima و Nagasakiو شو صار في العراق و
+
+114
+00:09:57,110 --> 00:10:02,410
+حتى شو صار في بلادنا طبعا هذه كلها عبارة عن ان ال
+
+115
+00:10:02,410 --> 00:10:06,230
+ionizing radiation is associated with acute and
+
+116
+00:10:06,230 --> 00:10:11,610
+chronic leukemia سجلة حالات في بعدها في كل أنواع
+
+117
+00:10:11,610 --> 00:10:16,850
+ال leukemia ايضا سجلة حالات في ال lymphoma
+
+118
+00:10:16,850 --> 00:10:24,150
+وبالتالي كل أنواع ال leukemia سجلة فيها ال ELLاللي
+
+119
+00:10:24,150 --> 00:10:27,390
+هو acute myelogenous leukemia acute lymphoplastic
+
+120
+00:10:27,390 --> 00:10:30,910
+leukemia chronic myelogenous leukemia كلها عبارة
+
+121
+00:10:30,910 --> 00:10:41,030
+عن حالات سجلت drugs أيضا سجلت حالات من ال leukemic
+
+122
+00:10:41,030 --> 00:10:48,460
+transformation associated with drugطبعا أشهر هذه
+
+123
+00:10:48,460 --> 00:10:52,560
+ال drugs هو ال benzine, chloraphenicol,
+
+124
+00:10:52,660 --> 00:10:55,780
+renalputazone, and cytotoxic alkylating
+
+125
+00:10:55,780 --> 00:11:00,100
+chemotherapeutic agents الناس اللي بتاخدوا كيماوي
+
+126
+00:11:00,100 --> 00:11:04,680
+شو بعمل الكيماوي؟ قالوا الكيماوي هو أو ال
+
+127
+00:11:04,680 --> 00:11:08,700
+cytotoxic alkylating chemotherapeutic agent هو
+
+128
+00:11:08,700 --> 00:11:12,200
+عبارة عن strongly electrophilic agents
+
+129
+00:11:14,530 --> 00:11:19,050
+بتطبق نيكلوفيليكسايت على ال DNA نيكلوفيليكسايت
+
+130
+00:11:19,050 --> 00:11:27,230
+يعني نيكليكسايت
+
+131
+00:11:27,230 --> 00:11:31,530
+نيكليكسايت نيكليكسايت
+
+132
+00:11:31,530 --> 00:11:35,130
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+133
+00:11:35,130 --> 00:11:35,970
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+134
+00:11:35,970 --> 00:11:35,970
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+135
+00:11:35,970 --> 00:11:35,970
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+136
+00:11:35,970 --> 00:11:38,470
+نيكليكسايت نيكليكسايت نيكليكسايت نيكليكسايت
+
+137
+00:11:38,470 --> 00:11:40,350
+نيكليكسايت
+
+138
+00:11:44,870 --> 00:11:50,350
+بيأتي لـ strand breaks , complex , rearrangement
+
+139
+00:11:50,350 --> 00:11:53,950
+بيأتي لـ deletion of part or all of the chromosome
+
+140
+00:11:53,950 --> 00:11:59,490
+شوف الفرق بينها، بين اللوكيميا اللي بتنتج عنالـ
+
+141
+00:11:59,490 --> 00:12:01,730
+chemotherapy يعني الـ therapy induced و بين
+
+142
+00:12:01,730 --> 00:12:05,770
+اللوكيميا الأصلية قالوا في تلات فروقات أساسية
+
+143
+00:12:05,770 --> 00:12:12,750
+الفرق الأول يعني في ال therapy induced acute non
+
+144
+00:12:12,750 --> 00:12:17,730
+lymphoplastic لوكيميا cases تسعين فالمية من
+
+145
+00:12:17,730 --> 00:12:21,570
+الحالات عندهم chromosomal cytogenetic abnormality
+
+146
+00:12:23,610 --> 00:12:26,850
+أشهر هذه الـ cytogenetic abnormality أو الكرمزوم
+
+147
+00:12:26,850 --> 00:12:32,010
+الابنورمالي هو الـ monosomy 5, 5Q-, monosomy 7,
+
+148
+00:12:32,150 --> 00:12:37,790
+and 7Q-, بينما أقل من 60% في الدنوهو الدنوهو يعني
+
+149
+00:12:37,790 --> 00:12:41,670
+الأصلية cases
+
+150
+00:12:41,670 --> 00:12:46,610
+عندهم cytogenetic abnormality و كرمزوم رقم خمسة
+
+151
+00:12:46,610 --> 00:12:55,940
+وسبعة usually are involved less commonlyالسبب
+
+152
+00:12:55,940 --> 00:13:00,040
+التاني او العامل التلفارق التاني هو اكتر من تلتين
+
+153
+00:13:00,040 --> 00:13:05,660
+حالات ثلاث بإنهيوس لوكيميا غالبا بيسبقها مرحلة
+
+154
+00:13:05,660 --> 00:13:11,690
+بيسموها pre-lokemic phase وفي هذه المرحلةاللي
+
+155
+00:13:11,690 --> 00:13:16,310
+بيكون فيه severe dysplastic changes و ineffective
+
+156
+00:13:16,310 --> 00:13:20,750
+hemopoiesis انت يعني مايعرفش يعني ineffective
+
+157
+00:13:20,750 --> 00:13:27,990
+hemopoiesis يعني premature cell death and in de
+
+158
+00:13:27,990 --> 00:13:34,630
+novo ال pre leukemic states او phase بيحدث في اقل
+
+159
+00:13:34,630 --> 00:13:39,320
+من الرابع هناك التلتين اقل من الرابعالفرق التالت
+
+160
+00:13:39,320 --> 00:13:42,920
+ال therapy induced is a refractory treatment و
+
+161
+00:13:42,920 --> 00:13:47,260
+المريض مايعيش أكتر من أربع شهور بينما ال donovo
+
+162
+00:13:47,260 --> 00:13:49,380
+ممكن يعيش عشرين شهر
+
+163
+00:13:53,230 --> 00:13:57,470
+النقطة التانية هي ال chemicals و يقولنا تعرض
+
+164
+00:13:57,470 --> 00:14:00,330
+الإنسان إلى chemicals زي المنزين زي ال cigarette
+
+165
+00:14:00,330 --> 00:14:05,310
+smokers زي المزارعين اللي بتعرضوا للمبيدات الحشرية
+
+166
+00:14:05,310 --> 00:14:11,650
+زي ال rubber industry workers زي حتى أطفال عاملين
+
+167
+00:14:11,650 --> 00:14:13,970
+في ال industry workers
+
+168
+00:14:17,690 --> 00:14:28,290
+والناس اللى مخدرين الاناستيزيا ايضا بيتعرض الفيروس
+
+169
+00:14:28,290 --> 00:14:37,370
+سجلت حالاتكثيرة طبعا associated with leukemia أشهر
+
+170
+00:14:37,370 --> 00:14:40,890
+هذه الحالات أمثل عليها هي human T cell leukemia
+
+171
+00:14:40,890 --> 00:14:47,290
+الفيروس واحد وجدوه هو عبارة عن causative agent لل
+
+172
+00:14:47,290 --> 00:14:54,530
+other T cell leukemia و ال HTLV2 وجدوه في atypical
+
+173
+00:14:54,530 --> 00:14:57,510
+heresy اللوكيمي و يعني هو من أنواع chronic
+
+174
+00:14:57,510 --> 00:14:59,150
+lymphocytic leukemia
+
+175
+00:15:02,600 --> 00:15:07,900
+موجود في البركتس الفومة و أول ما اكتشفوا هذه
+
+176
+00:15:07,900 --> 00:15:11,220
+الشغلات كانوا بيعتبروها الـ causative agent يعني
+
+177
+00:15:11,220 --> 00:15:15,600
+المسبب الأساسي لللو كيميا هي عبارة عن ال virus
+
+178
+00:15:15,600 --> 00:15:18,700
+incidence
+
+179
+00:15:18,700 --> 00:15:23,460
+ال overall incidence لللو كيميا هي تمانية العشر
+
+180
+00:15:23,460 --> 00:15:29,640
+حلوات لكل مئة ألف من ال population سنويًا يعني في
+
+181
+00:15:29,640 --> 00:15:38,450
+بلادنا فيه2 مليون يعني فعلا من 160 حالة إلى 200
+
+182
+00:15:38,450 --> 00:15:45,390
+حالة سنوي في غزة او في قطاع غزة نص هذه الحالات
+
+183
+00:15:45,390 --> 00:15:51,190
+acute و نص الداني chronic ولو كيميا بشكل عام تصيب
+
+184
+00:15:51,190 --> 00:15:57,390
+ال adult أكتر من الأطفال بالنسبة عشرة إلى واحد
+
+185
+00:15:58,880 --> 00:16:05,420
+وغالبا ال male أكتر من ال female بنسبة 1 إلى 2 إلى
+
+186
+00:16:05,420 --> 00:16:09,340
+1 بشكل
+
+187
+00:16:09,340 --> 00:16:12,880
+عام اللوكيميا بتسيب كل الأعمار لكن وجدوا ان ال
+
+188
+00:16:12,880 --> 00:16:17,180
+acute lymphoplastic لوكيميا بتسيب الأطفال بينما ال
+
+189
+00:16:17,180 --> 00:16:22,560
+acute myelogenous لوكيميا بتسيب الأكبر 75% من
+
+190
+00:16:22,560 --> 00:16:25,980
+حالات ال childhood لوكيميا هي عبارة عن acute
+
+191
+00:16:25,980 --> 00:16:30,550
+lymphoplastic لوكيميابينما 80% من حالة الـ Acute
+
+192
+00:16:30,550 --> 00:16:34,550
+Myelogenous Leukemia بتشوفها فى دكتورة ال chronic
+
+193
+00:16:34,550 --> 00:16:39,150
+leukemia بشكل عام هي عبارة عن disease of adult
+
+194
+00:16:39,150 --> 00:16:45,070
+chronic lymphocytic leukemiaخصوصاً في الاطفال
+
+195
+00:16:45,070 --> 00:16:53,350
+وغالباً ما نشاهدها قبل سن الأربعين الويلوجنس
+
+196
+00:16:53,350 --> 00:16:55,570
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+197
+00:16:55,570 --> 00:17:02,050
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+198
+00:17:02,050 --> 00:17:02,350
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+199
+00:17:02,350 --> 00:17:02,970
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+200
+00:17:02,970 --> 00:17:02,970
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+201
+00:17:02,970 --> 00:17:02,970
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+202
+00:17:02,970 --> 00:17:04,570
+الوكيميا الوكيميا الوكيميا الوكيميا الوكيميا
+
+203
+00:17:04,570 --> 00:17:12,510
+الوكيميا الوكيميا الوفهذه تقسيمة بشكل عام للاطفال
+
+204
+00:17:12,510 --> 00:17:17,470
+in terms of ال leukemia classification of leukemia
+
+205
+00:17:17,470 --> 00:17:23,870
+قسموها الى acute و chronic ويقسم ال acute الى
+
+206
+00:17:23,870 --> 00:17:27,690
+myeloid
+
+207
+00:17:27,690 --> 00:17:31,960
+و lymphoid حسب نوع الخليةو جاروا الـ Myeloid عبارة
+
+208
+00:17:31,960 --> 00:17:38,520
+عن تمان أنواع و اعطوها رمز M من Myeloid أول حرف من
+
+209
+00:17:38,520 --> 00:17:43,340
+Myeloid و باقنها تمان أنواع دوها عرقاب شهولة الـH
+
+210
+00:17:43,340 --> 00:17:50,220
+التفريق في M0, M1, M2 لغاية M7 بينما ال Limfoid
+
+211
+00:17:50,220 --> 00:17:56,880
+اعطوها أول حرف من Limfoid وهو Lفصار في عندنا acute
+
+212
+00:17:56,880 --> 00:17:59,860
+lymphoplastic leukemia و acute myelogenous
+
+213
+00:17:59,860 --> 00:18:03,620
+leukemia و جالوا ال acute lymphoplastic تلت أنواع
+
+214
+00:18:03,620 --> 00:18:08,420
+الواحد والاتنين والتلت ايضا ال chronic leukemia
+
+215
+00:18:08,420 --> 00:18:12,940
+according to the type of cells involved جالو هي
+
+216
+00:18:12,940 --> 00:18:16,780
+عبارة عن myeloid و lymphoid فأشهر أنواع ال myeloid
+
+217
+00:18:16,780 --> 00:18:20,860
+هي chronic myelogenous leukemia بينما ال lymphoid
+
+218
+00:18:20,860 --> 00:18:24,980
+يندرج تحتها اكتر من نوعزي ال chronic lymphocytic
+
+219
+00:18:24,980 --> 00:18:29,400
+leukemia برو lymphocytic leukemia هيريسل leukemia
+
+220
+00:18:29,400 --> 00:18:35,180
+هتترخ ليه كل هذه الأنواع ان شاء الله نهاية ال
+
+221
+00:18:35,180 --> 00:18:41,580
+course زي ما قلتلكوا قسموا ال leukemia لخمس عائلات
+
+222
+00:18:41,580 --> 00:18:47,860
+أساسية كل العائلة هي ال acute leukemia ثم ال
+
+223
+00:18:47,860 --> 00:18:56,310
+chronic leukemiaميلو ديس بلاستيك سندروه ميلو ديس
+
+224
+00:18:56,310 --> 00:19:05,210
+بلاستيك
+
+225
+00:19:05,210 --> 00:19:11,740
+سندروه ميلو ديس بلاستيك سندروهعائلة أخرى برد واحد
+
+226
+00:19:11,740 --> 00:19:15,280
+نيجي إيها بالتفصيل ثم non-leukemic
+
+227
+00:19:15,280 --> 00:19:19,960
+myeloproliferative disorders هي مش leukemia لكن في
+
+228
+00:19:19,960 --> 00:19:25,500
+proliferative يعني high proliferative capacity ثم
+
+229
+00:19:25,500 --> 00:19:29,140
+non-leukemic lymphoproliferative disorders
+
+230
+00:19:29,140 --> 00:19:32,760
+according to the cell type either مقسمها إلى نوعين
+
+231
+00:19:32,760 --> 00:19:38,760
+الmyeloid و ال lymphoidفهي خمس عائلات أساسية ان
+
+232
+00:19:38,760 --> 00:19:43,800
+شاء الله احنا نتفرق لكل هذه الأنواع بالتفصيل بشكل
+
+233
+00:19:43,800 --> 00:19:46,160
+عام الأكيد اللوكيميا by definition هي بره عن
+
+234
+00:19:46,160 --> 00:19:50,300
+اللوكيميا اللي بتتميز ب uncontrolled proliferation
+
+235
+00:19:50,300 --> 00:19:54,920
+of poorly differentiated cells ايش يعني poorly
+
+236
+00:19:54,920 --> 00:19:59,800
+differentiated يعني اللي لسه مش ناجة ال immature
+
+237
+00:19:59,800 --> 00:20:06,930
+cell بيسموها في هذه الحالة blast cellفالـ Leukemia
+
+238
+00:20:06,930 --> 00:20:10,810
+لكن الـ Acute Leukemia بتتميز بزيادة في عدد إيش
+
+239
+00:20:10,810 --> 00:20:15,850
+لبلاسل وقسموها لنوعين according to the predominant
+
+240
+00:20:15,850 --> 00:20:20,770
+cell lineage إلى Acute lymphoplastic و Acute non
+
+241
+00:20:20,770 --> 00:20:24,050
+lymphoplastic leukemia أو بيسموها Acute
+
+242
+00:20:24,050 --> 00:20:28,310
+myelogenous leukemia و هذه التقسيمة اللي حاكينا
+
+243
+00:20:28,310 --> 00:20:33,190
+عليها الـ Acute myeloid و الـ non myeloid
+
+244
+00:20:35,230 --> 00:20:40,670
+وقلنا ال AML هي تمان أنواع وال ALL هي تلات أنواع
+
+245
+00:20:40,670 --> 00:20:45,010
+ال chronic leukemia بتختلف عن ال acute leukemia ان
+
+246
+00:20:45,010 --> 00:20:50,530
+الخلايا الموجود المصابة فيها هي عبارة عن خلايا
+
+247
+00:20:50,530 --> 00:20:55,900
+تقريبا matureماشي some characteristic of maturity
+
+248
+00:20:55,900 --> 00:21:00,080
+بتكون واضحة جدا في ال chronic leukemia وفي أنواع
+
+249
+00:21:00,080 --> 00:21:03,580
+كثيرة زى ما قلنا هتتطلعق ليها chronic lymphocytic
+
+250
+00:21:03,580 --> 00:21:06,740
+leukemia, pro lymphocytic leukemia, heresy
+
+251
+00:21:06,740 --> 00:21:11,100
+leukemia and CML أو chronic myeloid leukemia
+
+252
+00:21:13,060 --> 00:21:16,900
+myelodysplastic syndrome عرفوها في البداية هي
+
+253
+00:21:16,900 --> 00:21:21,040
+عبارة عن الـ leukemic condition يعني حالة بتسبق
+
+254
+00:21:21,040 --> 00:21:25,840
+اللوكيميا يعني مرض من هالنوع بيجلب للوكيميا قسموه
+
+255
+00:21:25,840 --> 00:21:30,760
+according to the FAB ايه ال criteria FAB يا جماعة
+
+256
+00:21:30,760 --> 00:21:35,240
+الخير اختصار ل French American British scientist
+
+257
+00:21:35,240 --> 00:21:41,550
+مجموعة من العلماء الامريكان والبريطانيوالفرنسيين
+
+258
+00:21:41,550 --> 00:21:44,510
+جلسوا وعملوا Classification لكل أنواع اللوكيميا
+
+259
+00:21:44,510 --> 00:21:48,930
+قالوا انا خمس أنواع Refractory Anemia Refractory
+
+260
+00:21:48,930 --> 00:21:52,350
+Anemia with Excess Plast Refractory Anemia with
+
+261
+00:21:52,350 --> 00:21:56,370
+Excess Plast ثم Refractory Anemia with Excess
+
+262
+00:21:56,370 --> 00:21:59,170
+Plast and Transformation and Chronic
+
+263
+00:21:59,170 --> 00:22:06,130
+Myelomonasitic Lokemia وسبب ان ان اللوكيميك غالفة
+
+264
+00:22:06,130 --> 00:22:12,300
+ال disorder قسموها لنوعينبيندرج تحتها تلت أنواع
+
+265
+00:22:12,300 --> 00:22:16,120
+primary proliferative polycythemia و primary
+
+266
+00:22:16,120 --> 00:22:21,560
+thrombocythemia و ال myelofibrosis أيضا رح نحكي
+
+267
+00:22:21,560 --> 00:22:26,460
+فيهم التلاتة و ال lymphoproliferative disorders
+
+268
+00:22:26,460 --> 00:22:30,700
+برضه بيندرج تحتها تلاتة multiple myeloma and
+
+269
+00:22:30,700 --> 00:22:36,340
+plasma cell disorders and non Hodgkin disease و
+
+270
+00:22:36,340 --> 00:22:41,560
+برضه هذه عبارة عنتلت امثلا شاء الله احنا نتطرق
+
+271
+00:22:41,560 --> 00:22:46,900
+ديهم المقارنة في النهاية ما بين ال acute و ال
+
+272
+00:22:46,900 --> 00:22:52,480
+chronic تتمثل من جدول القاتل ف ال age على سبيل
+
+273
+00:22:52,480 --> 00:22:55,640
+المثال ال acute تصيب كل الأعمار ال chronic بس
+
+274
+00:22:55,640 --> 00:23:01,960
+الأضاءة طبعا هذا مش exclusive يعني مش ايش مش
+
+275
+00:23:01,960 --> 00:23:08,140
+strict لكن بشكل عامclinical onset في الـ acute
+
+276
+00:23:08,140 --> 00:23:11,880
+صدمة على طول بيجي المرض في الـ chronic insidious
+
+277
+00:23:11,880 --> 00:23:17,480
+براحة و بالصدفة بنكتشفه leukemic cells في الـ
+
+278
+00:23:17,480 --> 00:23:21,860
+acute ماتشور بينما في الـ chronic ماتشور الأنيميا
+
+279
+00:23:21,860 --> 00:23:26,300
+في الـ acute mild تسير بينما في الـ chronic بيبقى
+
+280
+00:23:26,300 --> 00:23:31,400
+الـ mild thrombocytopenia برضه في الـ acute mild
+
+281
+00:23:31,400 --> 00:23:35,440
+تسير بينما في الـ chronic mild
+
+282
+00:23:37,530 --> 00:23:42,510
+Y-species هي مختلفة في الأكيوت بينما دائما تزداد
+
+283
+00:23:42,510 --> 00:23:49,270
+في الأكرونك والأورجان وميجالي طبعا ليه هو غزو
+
+284
+00:23:49,270 --> 00:23:54,870
+الأعضاء الأخرى بالأكيوت مايلد لكن ملاقاش بالأكرونك
+
+285
+00:23:54,870 --> 00:23:59,950
+dominant يعني دائم في أورجان وميجالي للأعضاء
+
+286
+00:24:01,750 --> 00:24:06,750
+وبهيك بنكون أنا هنا أول محاضرة نرجو أن تكونوا قد
+
+287
+00:24:06,750 --> 00:24:08,470
+استمتعتوا معناه
+
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/ta9IAuJz01I.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/ta9IAuJz01I.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0db5a0425a3140e453a21c0a8f1c3364f3c5da40
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/ta9IAuJz01I.srt
@@ -0,0 +1,1685 @@
+1
+00:00:02,450 --> 00:00:06,930
+بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة
+
+2
+00:00:06,930 --> 00:00:15,450
+بعنوان tolerance وسنتطرق في هذه المحاضرة إلى عدة 
+
+3
+00:00:15,450 --> 00:00:21,650
+نقاط إن شاء الله but بداية نتعرف على definition of
+
+4
+00:00:21,650 --> 00:00:26,610
+tolerance. Tolerance is a type of specific
+
+5
+00:00:26,610 --> 00:00:31,510
+unresponsiveness to an antigen. بيخش انتيجن وما 
+
+6
+00:00:31,510 --> 00:00:35,030
+بيصير فيه immune response له. Induced by the
+
+7
+00:00:35,030 --> 00:00:37,790
+exposure of specific lymphocyte to that antigen.
+
+8
+00:00:37,790 --> 00:00:42,950
+It's induced يعني it's an active process but
+
+9
+00:00:42,950 --> 00:00:47,650
+response to other antigen normally. يعني أنا بدخل 
+
+10
+00:00:47,650 --> 00:00:54,820
+انتيجن معين بعمل بوجهه immune response لهذا 
+
+11
+00:00:54,820 --> 00:01:00,780
+الانتيجين فقط. لهذا الانتيجن فقط. تلرجين هو 
+
+12
+00:01:00,780 --> 00:01:03,200
+الانتيجن اللي يدفع للتلرنس. تلرجين هو الانتيجن
+
+13
+00:01:03,200 --> 00:01:05,760
+اللي يدفع للتلرنس. تلرجين هو الانتيجن اللي يدفع
+
+14
+00:01:05,760 --> 00:01:07,760
+للتلرنس. تلرجين هو الانتيجن اللي يدفع للتلرنس
+
+15
+00:01:07,760 --> 00:01:10,800
+تلرجين هو الانتيجن اللي يدفع للتلرنس. تلرجين هو
+
+16
+00:01:10,800 --> 00:01:15,520
+الانتيجن اللي يدفع للتلرنس. تلرجين هو الانتيجن
+
+17
+00:01:15,520 --> 00:01:16,200
+اللي يدفع للتلرنس. تلرجين هو الانتيجن اللي يدفع
+
+18
+00:01:16,200 --> 00:01:22,830
+للتلرنس. تلرجين هو الانتيجن اللي يدفع للتلرنس. لكن لا 
+
+19
+00:01:22,830 --> 00:01:27,750
+تتعامل معها. Normal individuals are tolerant to
+
+20
+00:01:27,750 --> 00:01:32,590
+their own antigen. بيسموه self-tolerance انه our
+
+21
+00:01:32,590 --> 00:01:39,070
+own antigen are tolerized.
+
+22
+00:01:39,070 --> 00:01:43,710
+Foreign antigen may be administered in a way that
+
+23
+00:01:43,710 --> 00:01:46,630
+preferentially inhibit immune response by inducing
+
+24
+00:01:46,630 --> 00:01:49,590
+tolerance in specific lymphocytes. أو بيسموها 
+
+25
+00:01:49,590 --> 00:01:54,010
+antigen induction. دخل الانتيجن أو في نفس الوجه اللي
+
+26
+00:01:54,010 --> 00:02:00,290
+بعمله is tolerance. Immunological feature. قالوا ال
+
+27
+00:02:00,290 --> 00:02:04,330
+process is an antigen induced and it's an active
+
+28
+00:02:04,330 --> 00:02:08,930
+process. وزي الـ immunological memory it's an
+
+29
+00:02:08,930 --> 00:02:14,970
+antigen specific. وأيضا it can exist in B cell and
+
+30
+00:02:14,970 --> 00:02:22,550
+T cell or both. وهي أسهل تدخل وتستمر أكثر في T-cell
+
+31
+00:02:22,550 --> 00:02:33,730
+من B-cell. وبالتالي هذه النقاط مقارنة ما بين الـ
+
+32
+00:02:33,730 --> 00:02:37,190
+immunological memory وما بين الـ tolerance.
+
+33
+00:02:37,190 --> 00:02:42,190
+Differences of immunological tolerance و
+
+34
+00:02:42,190 --> 00:02:46,310
+immunodeficiency و immunosuppression. شو الفرق؟ إن 
+
+35
+00:02:46,310 --> 00:02:49,410
+احنا بنحكي على tolerance يعني على انه دخل انتيجن
+
+36
+00:02:49,410 --> 00:02:54,210
+وما اشتغلنا أو ما اشتغل الـ immune response. فبنتوجّه 
+
+37
+00:02:54,210 --> 00:02:57,870
+شو الفرق بينها وبين الـ immunodeficiency أو الـ
+
+38
+00:02:57,870 --> 00:03:05,590
+immunosuppression. يعني في الـ immunodeficiency الـ
+
+39
+00:03:05,590 --> 00:03:09,170
+production of humor or self-mediated immunity is
+
+40
+00:03:09,170 --> 00:03:15,370
+not there. وبالتالي ليس محدود لأي انتيجن لأن هناك 
+
+41
+00:03:15,370 --> 00:03:19,970
+غياب لواحد أو أكثر من واحد من عناصر الـ immune
+
+42
+00:03:19,970 --> 00:03:25,510
+response. يبقى مافي immune response لكن الـ immune
+
+43
+00:03:25,510 --> 00:03:31,610
+response اللي غايب غايب لجميع الانتيجن. فبالتالي
+
+44
+00:03:31,610 --> 00:03:40,030
+ليس محدود لأي انتيجن. دراج معين أو أي أداة من أدوات 
+
+45
+00:03:40,030 --> 00:03:44,370
+اللي هو الـ suppression which include physical or
+
+46
+00:03:44,370 --> 00:03:51,410
+chemical. وبعمل suppression by using this tool. و
+
+47
+00:03:51,410 --> 00:03:59,170
+برضه هي عبارة عن non specific to an antigen. طيب 
+
+48
+00:03:59,170 --> 00:04:03,590
+induction of immunological tolerance. In fetal period
+
+49
+00:04:03,590 --> 00:04:06,790
+and neonate. قالوا أول من حكى في هذا الموضوع هو 
+
+50
+00:04:06,790 --> 00:04:14,190
+ميلر في 1945 لما وجد انه في tolerance ما بين الـ
+
+51
+00:04:14,190 --> 00:04:21,050
+antigen of two أو of two dizygotic twins.
+
+52
+00:04:21,050 --> 00:04:26,650
+Monozygotic twins, sorry. Monozygotic twins during 
+
+53
+00:04:26,650 --> 00:04:31,980
+fetal life. هذا ميلر. وهي الاتنين had the same 
+
+54
+00:04:31,980 --> 00:04:37,980
+vascular system. بيسموهم
+
+55
+00:04:37,980 --> 00:04:44,800
+dizygotic twin by experiment. Medwar. إيجي بعده هو 
+
+56
+00:04:44,800 --> 00:04:50,240
+وجماعته واشتغلوا على strain. إيش قال؟ قال إذا كان 
+
+57
+00:04:50,240 --> 00:04:56,720
+فيه فرق من strain A أخد graft من strain B it was
+
+58
+00:04:56,720 --> 00:05:09,620
+rejected. لكن إذا أخدنا cells من الـString B وحقنها
+
+59
+00:05:09,620 --> 00:05:16,920
+في
+
+60
+00:05:16,920 --> 00:05:25,890
+فار after birth على طول. في strain A لما يكبر لو 
+
+61
+00:05:25,890 --> 00:05:31,550
+أخدنا String Engraft من B و حققناها لـ A ما بيصيرش
+
+62
+00:05:31,550 --> 00:05:36,150
+Engraft rejection. لكن لو أخدناها من C و أعطينا 
+
+63
+00:05:36,150 --> 00:05:40,950
+إياها زي ما أنتم شايفين C will Engraft و B will
+
+64
+00:05:40,950 --> 00:05:46,090
+be rejected. بيسموها neonatal
+
+65
+00:05:54,720 --> 00:06:02,420
+tolerance. كأنه أخد خلايا من الـ Stream A وهو
+
+66
+00:06:02,420 --> 00:06:08,200
+الـ unit يعني after birth أخدناها 
+
+67
+00:06:08,200 --> 00:06:13,740
+و حققناها في Stream B و حققناها في Stream A. ولما
+
+68
+00:06:13,740 --> 00:06:22,040
+كبر أخدنا graft من 
+
+69
+00:06:22,040 --> 00:06:26,560
+B بعد 14 يوم صار له graft rejection.
+
+70
+00:06:29,250 --> 00:06:35,910
+أنا بدون حقن هذي strain A لحاله أخدنا من skin أخدنا
+
+71
+00:06:35,910 --> 00:06:39,510
+skin graft من strain B وحقلناها لـ B وحطناها على A.
+
+72
+00:06:39,510 --> 00:06:45,450
+بعد أسبوعين بده cellular rejection. لكن لو حقنا 
+
+73
+00:06:45,450 --> 00:06:51,730
+خلايا من strain B في strain A بعد الولادة مباشرة 
+
+74
+00:06:52,610 --> 00:06:58,510
+ماشي. بعد حوالي لما يكون طبعا بعد after six weeks
+
+75
+00:06:58,510 --> 00:07:03,970
+لو أخدنا اللي هو skin graft من B و حطناها على A
+
+76
+00:07:03,970 --> 00:07:07,990
+مش راح يصير له rejection. لكن لو عدنا الحكاية من
+
+77
+00:07:07,990 --> 00:07:14,810
+strain C ماشي وفي نفس الوقت كنا حقنين خلايا من 
+
+78
+00:07:14,810 --> 00:07:18,810
+strain B. فبالتالي برضه بيصير فيه graft rejection.
+
+79
+00:07:18,810 --> 00:07:27,850
+مانعه specific for graft for the cell that 
+
+80
+00:07:27,850 --> 00:07:35,830
+injected. Antigen and immunological tolerance
+
+81
+00:07:35,830 --> 00:07:41,030
+في الـ adult كانت بتعتمد على الـ concentration of
+
+82
+00:07:41,030 --> 00:07:44,390
+antigen. وفينا two types of antigen monomer or
+
+83
+00:07:44,390 --> 00:07:49,450
+aggregate. الـ pathway of antigen is also كيف مخش
+
+84
+00:07:49,450 --> 00:07:55,690
+الجسم وfeature of determinant. يعني الصفات الابتوب
+
+85
+00:07:55,690 --> 00:08:03,620
+هو هل هو teleogenic ابتوب ولا لأ. في اختلاف الانتيجن
+
+86
+00:08:03,620 --> 00:08:05,340
+في اختلاف الانتيجن. في اختلاف الانتيجن. في اختلاف 
+
+87
+00:08:05,340 --> 00:08:06,480
+الانتيجن. في اختلاف الانتيجن. في اختلاف الانتيجن. في 
+
+88
+00:08:06,480 --> 00:08:07,780
+اختلاف الانتيجن. في اختلاف الانتيجن. في اختلاف
+
+89
+00:08:07,780 --> 00:08:08,740
+الانتيجن. في اختلاف الانتيجن. في اختلاف الانتيجن. في 
+
+90
+00:08:08,740 --> 00:08:09,200
+اختلاف الانتيجن. في اختلاف الانتيجن. في اختلاف
+
+91
+00:08:09,200 --> 00:08:09,220
+اختلاف الانتيجن. في اختلاف الانتيجن. في اختلاف
+
+92
+00:08:09,220 --> 00:08:13,280
+الانتيجن. في اختلاف الانتيجن. في اختلاف الانتيجن. في
+
+93
+00:08:13,280 --> 00:08:25,280
+اختلاف الانتيجن. في اختلا
+
+94
+00:08:28,910 --> 00:08:33,070
+response. بس متى يكبر الـ dose بتلاقي الـ dose ايه اش
+
+95
+00:08:33,070 --> 00:08:45,870
+بتلاقي الـ immune response زاد ماشي لكن زي
+
+96
+00:08:45,870 --> 00:08:52,990
+ما أنتم شايفين أنا منطقة اللي هو dose وأنا منطقة
+
+97
+00:08:52,990 --> 00:08:56,890
+اللي هي high dose صار في tolerance. وأنا من المنطقة
+
+98
+00:08:56,890 --> 00:09:02,760
+اللي هو الانتيجن اللي احنا بنعمله immune response ده هو
+
+99
+00:09:02,760 --> 00:09:06,780
+secondary immune response. Faster and bigger. نعمل نفس
+
+100
+00:09:06,780 --> 00:09:12,620
+اللون يعني نفس الانتيجن. قالوا الـ tolerance for T 
+
+101
+00:09:12,620 --> 00:09:21,040
+cell هي أسهل واحدة وeven it needs
+
+102
+00:09:21,040 --> 00:09:26,870
+low amount of antigen. It lasts more. دا يه أكثر من
+
+103
+00:09:26,870 --> 00:09:33,250
+خمس... مية وخمسين يوم وضايّلة لسه عالية بينما الـ
+
+104
+00:09:33,250 --> 00:09:41,670
+B cell الـ survival time تبعتها أو الـ tolerance
+
+105
+00:09:41,670 --> 00:09:51,990
+ممكن يصل لخمسين يوم. والـ bomber B cell ده هي ممكن
+
+106
+00:09:51,990 --> 00:10:00,530
+تكون أقل حتى من خمسين يوم. العوامل
+
+107
+00:10:00,530 --> 00:10:04,030
+اللي تؤثر على الـ tolerance. قال الـ physical form of
+
+108
+00:10:04,030 --> 00:10:09,920
+antigen. الـ Large و Aggregate Complex Molecule
+
+109
+00:10:09,920 --> 00:10:15,480
+بيصير لها Probably Processed وبالتالي بيتقدم للـ 
+
+110
+00:10:15,480 --> 00:10:22,400
+Antigen. إذا كان Soluble أو Aggregate Free اللي هو 
+
+111
+00:10:22,400 --> 00:10:31,280
+Simple Small Molecule وبيكون Not Processed Root of 
+
+112
+00:10:31,280 --> 00:10:35,670
+Injection. إذا دخل subcutaneous أو Intramuscular
+
+113
+00:10:35,670 --> 00:10:41,790
+بيصير فيه resistance أو tolerance. لكن إذا كان صار 
+
+114
+00:10:41,790 --> 00:10:48,210
+في اللي هو إذا
+
+115
+00:10:48,210 --> 00:10:51,630
+كان subcutaneous أو Intramuscular بيصير فيه immune
+
+116
+00:10:51,630 --> 00:10:54,710
+response. لكن إذا كان oral أو sometimes intravenous
+
+117
+00:10:54,710 --> 00:10:59,870
+بيكون مافيش أو immune response. كمان الـ dose of
+
+118
+00:10:59,870 --> 00:11:03,490
+antigen تلعب دور كبير. الـ optimal dose هنا ممكن
+
+119
+00:11:03,490 --> 00:11:07,390
+اشتغل في الفار لكن very large or very small dose 
+
+120
+00:11:07,390 --> 00:11:10,570
+ممكن
+
+121
+00:11:10,570 --> 00:11:12,390
+اشتغل في الفار لكن very large or very small dose 
+
+122
+00:11:12,390 --> 00:11:12,450
+ممكن اشتغل في الفار لكن very large or very small
+
+123
+00:11:12,450 --> 00:11:12,550
+dose ممكن اشتغل في الفار لكن very large or very
+
+124
+00:11:12,550 --> 00:11:15,350
+ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل
+
+125
+00:11:15,350 --> 00:11:17,450
+في الفار ممكن اشتغل في الفار ممكن اشتغل في الفار
+
+126
+00:11:17,450 --> 00:11:21,490
+ممكن
+
+127
+00:11:21,490 --> 00:11:23,930
+اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في
+
+128
+00:11:23,930 --> 00:11:24,790
+الفار ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن
+
+129
+00:11:24,790 --> 00:11:29,410
+اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في
+
+130
+00:11:29,410 --> 00:11:37,610
+الفار ممكن اشتغل. طبعا fully differentiated بيكون
+
+131
+00:11:37,610 --> 00:11:42,630
+اللي هو tolerance immune response و بيعمل memory
+
+132
+00:11:42,630 --> 00:11:47,470
+and effector cell. لكن الـ newborn غالبا بيصير فيه 
+
+133
+00:11:47,470 --> 00:11:53,370
+أو immunologically immature. بيكون فيه لسه بيكون 
+
+134
+00:11:53,370 --> 00:11:59,390
+فيه tolerance أفضل لإن الجهاز المناعي لسه ماختمل.
+
+135
+00:12:00,020 --> 00:12:04,780
+Differentiation state of cells. الخلايا الكبيره 
+
+136
+00:12:04,780 --> 00:12:10,260
+only immunological in their nature. بيصير فيها
+
+137
+00:12:10,260 --> 00:12:17,320
+immune response. لكن الـ tolerance بيصير relative
+
+138
+00:12:17,320 --> 00:12:23,580
+undifferentiated بـ cell with only IgM أو T cell in
+
+139
+00:12:23,580 --> 00:12:24,900
+the thymic cortex.
+
+140
+00:12:28,620 --> 00:12:34,600
+هي الـ host هي الـ newborn وهي الـ adult and
+
+
+
+141
+00:12:34,600 --> 00:12:38,640
+of tolerance تخيلوا في كمية قليلة جدا صار في إيش 
+
+142
+00:12:38,640 --> 00:12:43,620
+في tolerance عند الـ newborn وهو برضه لسه قليلا لكن
+
+143
+00:12:43,620 --> 00:12:50,080
+بياخد مقروقة mechanism
+
+144
+00:12:50,080 --> 00:12:53,390
+of tolerance هنا يوجد نوعين، يوجد الـ Central
+
+145
+00:12:53,390 --> 00:12:56,150
+Tolerance ويوجد الـ Peripheral Tolerance الـ
+
+146
+00:12:56,150 --> 00:12:58,730
+Central Tolerance اللي بيحصل في الـ primary
+
+147
+00:12:58,730 --> 00:13:02,210
+lymphoid organs وبيحصل في يوم يكون فيه self
+
+148
+00:13:02,210 --> 00:13:05,050
+-reactive lymphocyte في الـ primary lymphoid organs
+
+149
+00:13:05,050 --> 00:13:10,590
+وإن كانت بمرض ارثايمس بصير فيه إيش اللي هو الـ
+
+150
+00:13:10,590 --> 00:13:14,530
+central tolerance الـ peripheral tolerance الخلايا
+
+151
+00:13:14,530 --> 00:13:19,970
+اللي بتهرب اللي بتطلع خطأ من الـ primary lymphoid
+
+152
+00:13:19,970 --> 00:13:22,290
+organs اللي هو بولمارو أو الثايمس بتطلع ال
+
+153
+00:13:22,290 --> 00:13:26,050
+periphery هناك برضه بصير اللي هي tolerance by
+
+154
+00:13:26,050 --> 00:13:30,330
+different means اللي هنتكلم فيها إن شاء الله في
+
+155
+00:13:30,330 --> 00:13:31,030
+المحاضرة
+
+156
+00:13:34,200 --> 00:13:39,960
+وهذه الصورة بتوضح تماما أن الانفوليبرالكاروسلسلب
+
+157
+00:13:39,960 --> 00:13:44,840
+تدين الانفوسايتز طبعا أن الانفوسايتز خاصة لمن؟ لـ
+
+158
+00:13:44,840 --> 00:13:53,600
+self energy تتفاعل معها لكنها إيه إيه إيه إيه إيه
+
+159
+00:13:53,600 --> 00:13:55,460
+إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه
+
+160
+00:13:55,460 --> 00:13:55,940
+إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه
+
+161
+00:13:55,940 --> 00:13:56,140
+إيه إيه إيه إيه
+
+162
+00:14:03,070 --> 00:14:06,990
+اللي هي non specific for self-antigen هذا يطلع
+
+163
+00:14:06,990 --> 00:14:10,470
+تيومة صادف antigen اللي هو الـ specific لها بسبب
+
+164
+00:14:10,470 --> 00:14:16,070
+clonal proliferation بينما لو هربت خلية من الـ primary
+
+165
+00:14:16,070 --> 00:14:21,070
+lymphoid organ وطلعت which is auto reactive cell
+
+166
+00:14:21,070 --> 00:14:27,310
+يعني reactive for self-antigen ماشي هتتفاعل معاها
+
+167
+00:14:27,310 --> 00:14:37,280
+وبعد فترة هتموت اللي هي داخلة عشان تدافع طبعا كانت
+
+168
+00:14:37,280 --> 00:14:41,040
+ميكانيزم of Tolerance deletion or energy or
+
+169
+00:14:41,040 --> 00:14:44,600
+lymphocyte that recognize self-antigen in the
+
+170
+00:14:44,600 --> 00:14:50,660
+periphery Central tolerance جالو اللي هو during
+
+171
+00:14:50,660 --> 00:14:53,400
+maturation of lymphocyte in the thymus
+
+172
+00:14:53,400 --> 00:15:00,660
+الليمفوسايت تتعرض لـ self-antigen وطبعا
+
+173
+00:15:00,660 --> 00:15:04,690
+في هذه الحالة أي خلية تتمسك في هذا الـ self-antigen
+
+174
+00:15:04,690 --> 00:15:10,750
+it was deleted by negative selection أيضا
+
+175
+00:15:10,750 --> 00:15:17,990
+الـ negative selection تحدث في الـ thymus الـ
+
+176
+00:15:17,990 --> 00:15:21,630
+negative selection اللي حصل في الـ thymus يؤدي إلى
+
+177
+00:15:21,630 --> 00:15:27,550
+أن الخلية إذا كانت auto-reactive ستحصل على
+
+178
+00:15:27,550 --> 00:15:31,130
+negative selection
+
+179
+00:15:33,440 --> 00:15:40,660
+Central Tolerance كما تشاهدون هذا يحدث في الانتجين
+
+180
+00:15:40,660 --> 00:15:48,940
+المرتبط بالخلايا الهيودنتراتيكسل وهو متقدم للخلايا
+
+181
+00:15:48,940 --> 00:15:53,300
+الاحتمال ارتباط
+
+182
+00:15:53,300 --> 00:15:57,480
+cell to cell contact في الـ بولمارو يؤدي إلى الآتي
+
+183
+00:15:57,480 --> 00:16:06,140
+إما يحدث في ابوبتوسيز ماشي لإنه في lack of
+
+184
+00:16:06,140 --> 00:16:12,420
+costimulation أو بيصير في apoptosis لإنه مرتبط
+
+185
+00:16:12,420 --> 00:16:17,200
+بالفاز بالفاز ليجند أو بيصير في clonal
+
+186
+00:16:17,200 --> 00:16:23,400
+proliferation لإنه أصلا خلية هادئة على سطحها كل لأن
+
+187
+00:16:23,400 --> 00:16:27,520
+هو الآن تقل الـ receptors ويبقى during اكتسبتهم
+
+188
+00:16:27,520 --> 00:16:32,310
+during maturation وبالتالي الخلايا هذه ممكن سيلها
+
+189
+00:16:32,310 --> 00:16:38,410
+surviving تطلع من الـ bone marrow كـ mature cell أو
+
+190
+00:16:38,410 --> 00:16:43,710
+من الـ thymus هذه خلية كما أنها ينطبق على الـ T
+
+191
+00:16:43,710 --> 00:16:47,490
+ينطبق على الـ B في الـ B في الـ bone marrow ده هو الـ
+
+192
+00:16:47,490 --> 00:16:52,090
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+193
+00:16:52,090 --> 00:16:52,890
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+194
+00:16:52,890 --> 00:16:52,950
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+195
+00:16:52,950 --> 00:16:53,610
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+196
+00:16:53,610 --> 00:16:54,150
+الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ
+
+197
+00:16:54,150 --> 00:16:57,930
+الـ الـ الـ الـ الـ الـ الـ يكون على سطحه إبتوب
+
+198
+00:16:57,930 --> 00:17:04,670
+multivalent self-antigen ماشي بسلها ابوبتوسز يعني
+
+199
+00:17:04,670 --> 00:17:11,190
+إذا تعرفت الـ IGM على self-antigen في داخل الخلية
+
+200
+00:17:11,190 --> 00:17:17,210
+أو في داخل الجسم بيعمل allograft وبيعمل ابوبتوسز
+
+201
+00:17:19,770 --> 00:17:23,410
+من الـ Peripheral Tolerance اللي بيصير فيه Clonal
+
+202
+00:17:23,410 --> 00:17:26,690
+Deletion وClonal Ignorance Clonal Deletion إنه
+
+203
+00:17:26,690 --> 00:17:30,930
+للخلايا بتخش وتتعرف على الانتجين وتعمل دليشن إما
+
+204
+00:17:30,930 --> 00:17:39,730
+بـ فاز فاز لجنت interaction أو إنه بيصير
+
+205
+00:17:39,730 --> 00:17:43,430
+يعني هذا بيسموه Clonal Deletion أو بيصير Clonal
+
+206
+00:17:43,430 --> 00:17:47,250
+Ignorance الانتجين إنه يخش الانتجين وما يسلقه
+
+207
+00:17:47,250 --> 00:17:53,330
+response لسببين إما أن الانتجين كميته قليلة وإما أن
+
+208
+00:17:53,330 --> 00:17:58,850
+الـ antibody اللي على سطح الـ B lymphocyte هو has
+
+209
+00:17:58,850 --> 00:18:07,110
+low affinity to to this antigen طبعا
+
+210
+00:18:07,110 --> 00:18:07,850
+فهذه الحالة
+
+211
+00:18:10,540 --> 00:18:13,380
+زي ما قلنا هذه الحلقة تحدث في الـ Peripheral لما
+
+212
+00:18:13,380 --> 00:18:20,620
+Viable Functional Lymphocyte تهرب من الـ Bone
+
+213
+00:18:20,620 --> 00:18:26,620
+marrow لـثة لـ Peripheral Blood Clonal
+
+214
+00:18:26,620 --> 00:18:33,240
+Energy إنه يحصل فيه Inactivation Due to a lack of
+
+215
+00:18:33,240 --> 00:18:43,550
+co-stimulatory signal الإنهاجري هو أن يحصل فيه فشلة
+
+216
+00:18:43,550 --> 00:18:49,630
+الخلية لإنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+217
+00:18:49,630 --> 00:18:50,290
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+218
+00:18:50,290 --> 00:18:51,170
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+219
+00:18:51,170 --> 00:18:51,350
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+220
+00:18:51,350 --> 00:18:51,670
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+221
+00:18:51,670 --> 00:18:52,130
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي
+
+222
+00:18:52,130 --> 00:18:54,130
+إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارج
+
+223
+00:18:58,180 --> 00:19:04,840
+نقطة ثانية طبعا هذا في الوضع
+
+224
+00:19:04,840 --> 00:19:11,880
+الطبيعي هيك مصيره لكن لما يدخل الـ antigen ماشي
+
+225
+00:19:11,880 --> 00:19:20,980
+مرتبط بالبيلم for science اللي الاحتمال أنه أنه
+
+226
+00:19:20,980 --> 00:19:26,140
+خلية تموت اللي تصدت لهذا الـ antigen لإنه طلع الـ
+
+227
+00:19:26,140 --> 00:19:32,720
+antigen immunogenic أو إنه يكون هناك إنرجي يعني
+
+228
+00:19:32,720 --> 00:19:36,960
+functional unresponsiveness أو أبوبتوسز لنفس الخلية
+
+229
+00:19:36,960 --> 00:19:40,960
+يعني إيه الخلية؟ بتنوض يا إما بتعمل induction
+
+230
+00:19:40,960 --> 00:19:46,580
+للأبوبتوسز وبالتالي بتنوض غيرها يا إما بده يسلها
+
+231
+00:19:46,580 --> 00:19:54,280
+inactivation by energy طبعا these الـ ignorance زي
+
+232
+00:19:54,280 --> 00:20:00,290
+ما قلنا بتدخل الانتجين لكن we ignore it ليش؟ ده لأما
+
+233
+00:20:00,290 --> 00:20:04,990
+لإنه في له affinity to that antigen أو لإنه تركيزه
+
+234
+00:20:04,990 --> 00:20:09,970
+قليل جدا فبيصير فيش response لكن ممكن يصير response
+
+235
+00:20:09,970 --> 00:20:17,430
+لو اتعرضت لـ immunogenic antigen فهي
+
+236
+00:20:17,430 --> 00:20:21,050
+بتبين أنها اللي هو الـ normal response هي
+
+237
+00:20:21,050 --> 00:20:26,360
+الارتباطات وهي CD28 مع B7 وهي الـ MHC مرتبط بالـ
+
+238
+00:20:26,360 --> 00:20:35,300
+Class II MHC وهو لما اتعرض لـ Antigen صار فيه
+
+239
+00:20:35,300 --> 00:20:42,460
+Clonal Proliferation وصار فيه Death الـ energy هي
+
+240
+00:20:42,460 --> 00:20:47,420
+نفس الحكاية لكن ناقص صار بس الـ first signal اللي
+
+241
+00:20:47,420 --> 00:20:58,810
+هو الـ MHC مقدم الـ Antigen لـ PCR ماشي وبالتالي الـ
+
+242
+00:20:58,810 --> 00:21:06,510
+TCR sorry وبالتالي antigen is recognized لكن ما
+
+243
+00:21:06,510 --> 00:21:10,070
+اتكونت costimulatory reaction اللي تدعم عملية
+
+244
+00:21:10,070 --> 00:21:13,270
+التفاعل أو
+
+245
+00:21:26,220 --> 00:21:31,860
+CD8786 بيرتبط مباشرة بالامينوجلوبيولين على سطح
+
+246
+00:21:31,860 --> 00:21:39,000
+الخلايا في هذه الحالة الارتباط يتم من خلال
+
+247
+00:21:39,000 --> 00:21:46,100
+الـ انهيبوتوري سايتوكاين والـ CTLA4 ارتبط في CD28
+
+248
+00:21:46,100 --> 00:21:52,280
+اللي موجود على سطح الـ B-Lymphocyte فصار فيه
+
+249
+00:21:52,280 --> 00:21:57,300
+Energy يعني الـ Energy ممكن تصير By Inactivation
+
+250
+00:21:57,300 --> 00:22:02,920
+يعني Inhibition ماشي من خلال CTLA4 أو By Deletion
+
+251
+00:22:06,050 --> 00:22:11,990
+أي قلولة الانرجيا أيضا صارت للتي الانفوسايت قدم لها
+
+252
+00:22:11,990 --> 00:22:18,230
+يعني عرضت لها اللي هي الـ first signal لكن الـ
+
+253
+00:22:18,230 --> 00:22:23,650
+second signal ما حصلها والسبب في ذلك أنه في
+
+254
+00:22:23,650 --> 00:22:28,530
+inappropriate اللي هو antigen presentation إيش الـ
+
+255
+00:22:28,530 --> 00:22:29,510
+antigen من الشجرة
+
+256
+00:22:40,120 --> 00:22:44,960
+هو يقلن الانيرجي نفس الحكاية للـ B-Lymphocytes يوم
+
+257
+00:22:44,960 --> 00:22:49,960
+يكون فيه صليب الانتجين بكميات كبيرة الخلية الـ B
+
+258
+00:22:49,960 --> 00:22:56,720
+-Lymphocyte أيضا بيصير فيها انيرجي أو يوم
+
+259
+00:22:56,720 --> 00:23:02,620
+أي خلية ترتبط الفاز بالفاز لجند it will induce
+
+260
+00:23:02,620 --> 00:23:03,500
+apoptosis
+
+261
+00:23:06,920 --> 00:23:09,820
+طريقة أخرى من طرق الـ suppression in the
+
+262
+00:23:09,820 --> 00:23:15,540
+peripheral blood وهي باستخدام TS T suppressor cell
+
+263
+00:23:15,540 --> 00:23:19,040
+طبعا هذه بتعمل suppression لك و it's not specific
+
+264
+00:23:19,040 --> 00:23:26,440
+أكيد شغلها is not specific لكل T lymphocytes or by
+
+265
+00:23:26,440 --> 00:23:29,640
+action of cytokine بعد الخلايا بتفرز تتعامل بـ
+
+266
+00:23:29,640 --> 00:23:32,200
+growth factor beta and IL-10 and these are
+
+267
+00:23:32,200 --> 00:23:35,720
+inhibitory cytokine بيعملوا inhibition للميو
+
+268
+00:23:35,720 --> 00:23:40,400
+ريسبونس or hold back in signal transduction ماوصلتش
+
+269
+00:23:40,400 --> 00:23:44,740
+الـ signal لنكليز عشان يكون فيه اللي هو gene
+
+270
+00:23:44,740 --> 00:23:48,960
+transcription وبالتالي
+
+271
+00:23:48,960 --> 00:23:55,020
+translation وبالتالي ما صارش فيه function
+
+272
+00:23:55,020 --> 00:24:00,560
+immunologically privileged sites في بعض الأماكن لا
+
+273
+00:24:00,560 --> 00:24:06,820
+يحدث فيها immune response وبالتالي لا بيحدث لها
+
+274
+00:24:07,650 --> 00:24:13,450
+self antigen ولا لـ foreign antigen ولا لأي حاجة
+
+275
+00:24:13,450 --> 00:24:18,530
+وهذه الأماكن أشهرها اللي هي الـ cornea of the
+
+276
+00:24:18,530 --> 00:24:27,170
+heart of the eye و الـ brain و testis
+
+277
+00:24:27,170 --> 00:24:33,190
+و اللهم صلى الله عليه وسلم و عظمك placenta كل هذه
+
+278
+00:24:33,190 --> 00:24:40,480
+أماكن ما يصير فيها immune response هذه صورة تظهر لي
+
+279
+00:24:40,480 --> 00:24:45,460
+ملخص التولرانس
+
+280
+00:24:46,800 --> 00:24:49,780
+الأولاني هو عبارة عن normal immune response ده هو
+
+281
+00:24:49,780 --> 00:24:52,640
+ارتبط وأخذت two signals وصار فيه proliferation
+
+282
+00:24:52,640 --> 00:24:56,700
+differentiation ونشطت اللي هو T lymphocytes
+
+283
+00:24:56,700 --> 00:25:01,240
+فالتاني شو اللي صار كان صار energy كيف بيصير ال
+
+284
+00:25:01,240 --> 00:25:04,640
+energy قالوا أما بيصير في lack of costimulation هي
+
+285
+00:25:04,640 --> 00:25:07,780
+without costimulation يعني without the second
+
+286
+00:25:07,780 --> 00:25:12,560
+signal كنا بنعرف أن هو الخلية عشان تتمشط تحتاج إلى
+
+287
+00:25:12,560 --> 00:25:17,710
+two signals وبالتالي الأولى صارت لكن الثانية ما ..
+
+288
+00:25:17,710 --> 00:25:19,890
+اللي هو الـ Costimulatory Reaction ما صارت
+
+289
+00:25:19,890 --> 00:25:24,190
+وبالتالي صارت دخلت في anergy أو أنه صارت بس من خلال
+
+290
+00:25:24,190 --> 00:25:29,230
+ارتباط بـInhibitory Receptor هي الـB7 ارتبط
+
+291
+00:25:29,230 --> 00:25:35,930
+بـCTLA4 طبعا هذا عامل  unresponsiveness برضه أو
+
+292
+00:25:35,930 --> 00:25:42,860
+by deletion ده هو الفاز ارتبط بالـFas ligand أدى إلى
+
+293
+00:25:42,860 --> 00:25:49,260
+apoptosis أو أن الـ cytokine mediated suppression
+
+294
+00:25:49,260 --> 00:25:53,100
+قلنا بعض الخلايا بتفرز inhibitory cytokine اللي
+
+295
+00:25:53,100 --> 00:25:59,560
+بتعمل inhibition لـIL-2 وبالتالي لا يحدث نشاط
+
+296
+00:25:59,560 --> 00:26:03,400
+وبالتالي inhibition of proliferation and effector
+
+297
+00:26:03,400 --> 00:26:08,680
+action زي ما أنتم عارفين هي الخلية تحتاج إلى two
+
+298
+00:26:08,680 --> 00:26:15,170
+signals بتبعث الأولاني ثم بي سيفر مع CD 28 بتبعث
+
+299
+00:26:15,170 --> 00:26:22,290
+الأولاني وبالتالي ده هو إشارة ثم Signal 2 بدها
+
+300
+00:26:22,290 --> 00:26:27,530
+تكون برضه تحصل وبتدينا إشارة محصلة هذا الكلام
+
+301
+00:26:27,530 --> 00:26:33,660
+activated تيهي البصرهذه عبارة عن اللي هو الـ
+
+302
+00:26:33,660 --> 00:26:36,680
+tolerance في غياب الـ Co-Stimulatory Reaction اللي
+
+303
+00:26:36,680 --> 00:26:42,040
+هو Signal واحد بتصير لكن Signal اتنين is absent
+
+304
+00:26:42,040 --> 00:26:47,020
+فبيصير Tolerance أو anergy أو Apoptosis from lack
+
+305
+00:26:47,020 --> 00:26:51,340
+of Signal لك
+
+306
+00:26:51,340 --> 00:26:55,120
+of Co-Stimulation can lead to Tolerance أو anergy
+
+307
+00:26:55,120 --> 00:27:00,400
+طبعا هي هذا ال normal immune responseهنا ما فيش co
+
+308
+00:27:00,400 --> 00:27:03,640
+-stimulation صار فيه anergy صار فيه ارتباط ب
+
+309
+00:27:03,640 --> 00:27:08,300
+inhibitory receptor اللي هو CTLA4 أو Cytotoxic
+
+310
+00:27:08,300 --> 00:27:12,740
+Lymphocyte Antigen رقم 4 وبالتالي صار في أن ايش
+
+311
+00:27:12,740 --> 00:27:16,640
+unresponsiveness
+
+312
+00:27:16,640 --> 00:27:21,500
+أو anergy regulatory by cytokine هاي آليات الـ
+
+313
+00:27:21,500 --> 00:27:23,420
+Transforming Growth Factor Beta عملت عن
+
+314
+00:27:23,420 --> 00:27:26,980
+responsiveness to the activation of T lymphocyte
+
+315
+00:27:26,980 --> 00:27:32,140
+وهذه عبارة عن ال pathways ملخصة ماشية for
+
+316
+00:27:32,140 --> 00:27:37,100
+peripheral tolerance هذا ال normal وهذه الأولاني
+
+317
+00:27:37,100 --> 00:27:42,640
+عبارة عن anatomical barriers أو immunological
+
+318
+00:27:42,640 --> 00:27:47,280
+tolerance دخل الأنتيجين بس ما صار فيه له أو يكون
+
+319
+00:27:47,280 --> 00:27:50,240
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+320
+00:27:50,240 --> 00:27:54,360
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+321
+00:27:54,360 --> 00:27:58,720
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+322
+00:27:58,720 --> 00:27:59,640
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+323
+00:27:59,640 --> 00:28:01,260
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+324
+00:28:01,260 --> 00:28:02,580
+الأنتيجين مرتبط بالـFas بالـFas ligand أو يكون
+
+325
+00:28:02,580 --> 00:28:05,040
+الأنتيجين مرتبط بالـFas ligand أو يكون الأنتيجين مرتبط
+
+326
+00:28:05,040 --> 00:28:09,280
+بالـFas ligand أو يكون الأنتيجين مرتبط بالـFas ligand
+
+327
+00:28:09,280 --> 00:28:15,560
+أو يكون الأنتيجين مرتبط بالـFas ligand أو يكون
+
+328
+00:28:22,280 --> 00:28:25,860
+طريقة أخرى من الأرض Induction of Tolerance by
+
+329
+00:28:25,860 --> 00:28:31,780
+Antibody Inhibition by Antibody Feedback شو بتعمل؟
+
+330
+00:28:31,780 --> 00:28:35,960
+قالوا بيقعدوا Antibody شو بيعمل؟ بيمسك الـ Antigen
+
+331
+00:28:35,960 --> 00:28:40,580
+وبالتالي الخلية
+
+332
+00:28:40,580 --> 00:28:45,480
+اللي ناشطة أو specific for that Antigen will not
+
+333
+00:28:45,480 --> 00:28:49,120
+encounter that Antigen مش ساعة تقابله يعني وكأننا
+
+334
+00:28:49,120 --> 00:29:01,180
+بنعمل Neutralization لمين؟للـ Antigen وأنا
+
+335
+00:29:01,180 --> 00:29:05,380
+أشهر هذه أو الأمثلة على ذلك اللي هو الـ RhTD اللي
+
+336
+00:29:05,380 --> 00:29:10,460
+بنعطيه في حالات الارترو بلاستوسيز في تانيس أو في
+
+337
+00:29:10,460 --> 00:29:14,500
+حالات المولادة إذا كان في تعارض للأنتيجين شو بيعمل
+
+338
+00:29:14,500 --> 00:29:21,080
+بعمل neutralization لمن؟ للأنتيجين وبالتالي بيبطل
+
+339
+00:29:21,660 --> 00:29:29,140
+يواجه الخلية وينشطها مجرد Inhibitory Receptor قال أن
+
+340
+00:29:29,140 --> 00:29:32,720
+الـInhibitory Receptor على الـB-cell في FC Gamma
+
+341
+00:29:32,720 --> 00:29:38,300
+Receptor 2 وعلى الـT-cell في Cytotoxic Lymphocyte
+
+342
+00:29:38,300 --> 00:29:44,640
+Antigen number 4 وعلى الـNK cell في KIR Killer
+
+343
+00:29:44,640 --> 00:29:48,020
+Inhibitory Receptor اللي هو عبارة عن
+
+344
+00:29:48,020 --> 00:29:50,460
+Immunoglobulin-like Receptor
+
+345
+00:29:53,100 --> 00:29:56,280
+Anti-Idiotypes and Immune Regulation جعلوا الـ
+
+346
+00:29:56,280 --> 00:30:00,460
+Anti-Idiotypes وقبل عن Antibody ضد الـFab region of
+
+347
+00:30:00,460 --> 00:30:04,240
+Antibody وبالتالي بيعمل Blocking لمين؟
+
+348
+00:30:04,240 --> 00:30:10,460
+للـFab region وبالتالي بيصير فيه unresponsiveness
+
+349
+00:30:10,460 --> 00:30:17,280
+بيصير فيه unresponsiveness أي واحد بيمسك فيه في
+
+350
+00:30:17,280 --> 00:30:20,640
+الـFab هاي الـAntibody وهي الـAntibody الـAntibody
+
+351
+00:30:20,640 --> 00:30:24,900
+هذا ماسك في الـFab هذه كمان هنا ماسك في الـFab ثاني
+
+352
+00:30:24,900 --> 00:30:30,940
+وهكذاOral Tolerance يعني الـOral Tolerance طبعا زي
+
+353
+00:30:30,940 --> 00:30:33,680
+ما احنا عارفين الأكل بت .. بيخش جوا والأكل مليان
+
+354
+00:30:33,680 --> 00:30:37,660
+أنتيجينات شو اللي بيصير يعني في خانيتين بتلعب دور
+
+355
+00:30:37,660 --> 00:30:42,360
+كبير في Tolerance الـOral Tolerance الـTR3 والـTR1 الـ
+
+356
+00:30:42,360 --> 00:30:47,450
+TR1 بتلعب دور كبير بإيش؟ بإللي هو inducing
+
+357
+00:30:47,450 --> 00:30:50,390
+inhibitory cytokine أو secreting inhibitory
+
+358
+00:30:50,390 --> 00:30:55,530
+cytokine T البرتلاتة بتعتمد على كمية الأنتيجين
+
+359
+00:30:55,530 --> 00:31:00,930
+فإذا كان في low antigen dose بيصير في T البرتلاتة
+
+360
+00:31:00,930 --> 00:31:06,970
+suppression ماشي by
+
+361
+00:31:06,970 --> 00:31:11,590
+طبعا ال low dose خلاص بيصير في ارتباط و inhibition
+
+362
+00:31:12,180 --> 00:31:15,600
+الـhigh dose جزء منه يصبح absorption مباشرة
+
+363
+00:31:15,600 --> 00:31:21,280
+وبتصير فيه anergy لإنه ما بيصير فيه co-stimulatory
+
+364
+00:31:21,280 --> 00:31:28,440
+reaction formation الـHorror Autoimmune Tolerance الـHorror
+
+365
+00:31:28,440 --> 00:31:30,720
+Tolerance اللي هو حكيتهم بالتلاتة الـImmune
+
+366
+00:31:30,720 --> 00:31:34,600
+privileged ساعد قلت لكم في بعض الأماكن هذه الأماكن
+
+367
+00:31:34,600 --> 00:31:41,630
+بيسموها Immune Privileged يعني محصنة مناعيا لأنه ما
+
+368
+00:31:41,630 --> 00:31:46,510
+بيصير فيها Immune Response أما هذه الأماكن هي ال
+
+369
+00:31:46,510 --> 00:31:49,130
+eye والـtestis والـbrain والـovary والـ
+
+370
+00:31:49,130 --> 00:31:53,290
+placenta إيش اللي بيصير جواها في هذه الأماكن ممكن
+
+371
+00:31:53,290 --> 00:31:57,510
+Fas ligand بلعب دور كبير في الـImmune
+
+372
+00:31:57,510 --> 00:32:02,190
+privileged sites Biological Tolerance و Clinical
+
+373
+00:32:06,200 --> 00:32:10,960
+in clinical medicine عشان نعمل Immunological
+
+374
+00:32:10,960 --> 00:32:15,780
+trials نعملوه عشان نحقق الأهداف القاتية نمرة واحد
+
+375
+00:32:15,780 --> 00:32:20,240
+to prevent the rejection of organ allograft and
+
+376
+00:32:20,240 --> 00:32:24,020
+xenograft نمرة اتنين to treat autoimmune نمرة
+
+377
+00:32:24,020 --> 00:32:30,100
+تلاتة to treat allergy أيضا
+
+378
+00:32:30,100 --> 00:32:43,230
+to treat اللي هو tumor induction of tolerance طبعا
+
+379
+00:32:43,230 --> 00:32:50,630
+by enhancement of طبعا هذا العكس ماشي عشان أعمل
+
+380
+00:32:50,630 --> 00:32:57,430
+termination للـTolerance زي
+
+381
+00:32:57,430 --> 00:33:01,470
+في حالات اللي هو tumor cell أو في حالات infectious
+
+382
+00:33:02,610 --> 00:33:06,190
+infection disease بعمل Termination للـTolerance عشان
+
+383
+00:33:06,190 --> 00:33:10,410
+يكون فيه Good Immune Response وهذه بتحكي على
+
+384
+00:33:10,410 --> 00:33:14,190
+Clinical Phase زي ما أنتم شايفين هذا المريض صار
+
+385
+00:33:14,190 --> 00:33:20,290
+عنده Hematoma في هذه المنطقة سموها Hep Hematoma أو
+
+386
+00:33:20,290 --> 00:33:21,450
+Line Hematoma
+
+387
+00:33:23,670 --> 00:33:27,330
+وش اللي صار تفاصيل هذه الحالة جاله six years old
+
+388
+00:33:27,330 --> 00:33:30,830
+male طفل عمره ست سنوات اجى على ال emergency room
+
+389
+00:33:30,830 --> 00:33:35,150
+with unexplained bruising في إندونازيف due to
+
+390
+00:33:35,150 --> 00:33:41,130
+minor trauma لما دوروا على ال coagulation factor
+
+391
+00:33:41,130 --> 00:33:45,090
+لجوا factor 8 level is less than one percent
+
+392
+00:33:45,090 --> 00:33:50,790
+of normal قال الـpatient اعطوه factor 8
+
+393
+00:33:50,790 --> 00:33:56,900
+concentrate وسابوه كانوا حرروه وطلعوه من المستشفى
+
+394
+00:33:56,900 --> 00:34:13,800
+لكن بعد two weeks رجع ماشي أرجع 
+
+395
+00:34:13,800 --> 00:34:16,900
+بطلتين in two weeks اه والـsame problem مش
+
+396
+00:34:16,900 --> 00:34:20,820
+الدعوة أعطوه factor 8 مرة ثانية لكن factor
+
+397
+00:34:20,820 --> 00:34:27,080
+8 مش شغال ليش؟ قالوا فيه Anti-Factor 8
+
+398
+00:34:27,080 --> 00:34:31,280
+Activity ماهو الدعوة؟ قالوا صار في Lack of
+
+399
+00:34:31,280 --> 00:34:38,160
+Tolerance Lack of Tolerance الحالة
+
+400
+00:34:38,160 --> 00:34:43,160
+هذه بتصير الـprevalence فيها من عشرين لثلاثين في
+
+401
+00:34:43,160 --> 00:34:47,840
+المية من حالات Factor 8 وأقل في Factor 9 شو
+
+402
+00:34:47,840 --> 00:34:49,940
+بيقعدوا في هذه الحالة؟ قالوا بيقعدوا في Factor 8
+
+403
+00:34:49,940 --> 00:34:54,320
+Concentrate or Recombinant Factor 8 بكميات كبيرة ثم
+
+404
+00:34:54,320 --> 00:35:02,380
+inhibitors تتطور لتنهيز الفاكتور 8 therapy
+
+405
+00:35:02,380 --> 00:35:07,640
+أهم علاجات ممكن تعمل Inhibition لفاكتور 8
+
+406
+00:35:07,640 --> 00:35:15,300
+antibody قالوا أنك تعطي Porcine Factor 8
+
+407
+00:35:15,300 --> 00:35:19,480
+Porcine اللي هو جاي من الخنازير وهذا طبعا لسه
+
+408
+00:35:19,480 --> 00:35:21,260
+cross-reactivity
+
+409
+00:35:24,080 --> 00:35:30,340
+والـImmunogenicity تبعته أقل من العادي الـTolerance
+
+410
+00:35:30,340 --> 00:35:35,340
+فيه high تحقق الـTolerance بعطاء اللي هو factor
+
+411
+00:35:35,340 --> 00:35:42,600
+8 بكميات كبيرة أو أنك تعمل gene therapy إيش
+
+412
+00:35:42,600 --> 00:35:47,460
+الـinhibitors اللي ممكن يكون IgG وله أربعة sub
+
+413
+00:35:47,460 --> 00:35:52,390
+classes من واحد لأربعة الـConditional Factor
+
+414
+00:35:52,390 --> 00:35:56,370
+Deficiency يمكن أن يكون الـAutoimmune والذي قبل
+
+415
+00:35:56,370 --> 00:36:02,490
+ذلك أثر على واحد لم يحدث له قبل ذلك يكون الـ
+
+416
+00:36:02,490 --> 00:36:03,170
+Autoimmune.
+
+417
+00:36:05,550 --> 00:36:08,410
+It's usually associated with pregnancy,
+
+418
+00:36:08,610 --> 00:36:12,270
+autoimmunity, malignancy, multi-transfusion.
+
+419
+00:36:13,090 --> 00:36:18,570
+advanced age وهكذا
+
+420
+00:36:18,570 --> 00:36:23,830
+أنهينا المحاضرة أرجو أن تكونوا قد استفدتم وشكرا
+
+Okay, please provide the Arabic/English lecture transcript you would like me to review and correct for typos and grammatical errors. I will ensure to follow all the guidelines you provided. 
+
+I'm ready to assist you in producing a clean and accurate transcript.  
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4.srt
new file mode 100644
index 0000000000000000000000000000000000000000..ffbd2bd714840d8483a8f1878f7cf3c92ccdb79b
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4.srt
@@ -0,0 +1,1411 @@
+1
+00:00:02,700 --> 00:00:05,860
+بسم الله الرحمن الرحيم و به نستعين و عليه نتوكل و
+
+2
+00:00:05,860 --> 00:00:12,440
+أجمعين كنا في السابق في محاضرة سابقة قد تطرقنا إلى 
+
+3
+00:00:12,440 --> 00:00:16,720
+الnutritional anemia من خلال شرح ال iron
+
+4
+00:00:16,720 --> 00:00:20,740
+metabolic disorder و هي مثال حي على microcytic
+
+5
+00:00:20,740 --> 00:00:25,320
+hypochromic anemia واليوم إن شاء الله سنتطرق إلى
+
+6
+00:00:25,320 --> 00:00:28,940
+نوع آخر من ال nutritional anemia و هي ال
+
+7
+00:00:28,940 --> 00:00:34,950
+megaloplastic anemia ومسبباتها which are mainly
+
+8
+00:00:34,950 --> 00:00:41,250
+vitamin B12 and folic acid وإن كان في أسباب أخرى
+
+9
+00:00:41,250 --> 00:00:48,290
+سنتطرق إليها أيضا الانيميا of vitamin B12 and
+
+10
+00:00:48,290 --> 00:00:54,310
+folic acid هي غالبا أنيميا سموها megaloplastic
+
+11
+00:00:54,310 --> 00:01:01,460
+أنيمياVitamin B12 دعونا نتطرق إلى كما تعودنا إلى
+
+12
+00:01:01,460 --> 00:01:05,040
+الchemistry of vitamin B12 and folic acid
+
+13
+00:01:05,040 --> 00:01:09,940
+نبدأ بال vitamin B12 و ال vitamin B12 هو عبارة عن
+
+14
+00:01:09,940 --> 00:01:15,680
+مركب دهني و قدامكوا على شريحة بيتكوّن من ثلاثة main
+
+15
+00:01:15,680 --> 00:01:21,680
+structures الأولانية وهي محاطة باللون الأزرق وهي
+
+16
+00:01:21,680 --> 00:01:25,200
+عبارة عن four spiral rings هذه هي four spiral rings
+
+17
+00:01:26,230 --> 00:01:34,250
+يتوسط ال four pyrorings كوبلت ذرة مرتبطة ب
+
+18
+00:01:34,250 --> 00:01:38,410
+chemical group يبقى في عندنا pyrorings و في عندنا
+
+19
+00:01:38,410 --> 00:01:44,450
+كوبلت ذرة ثم في عندنا ال chemical group هذا هو
+
+20
+00:01:44,450 --> 00:01:51,830
+عبارة عن vitamin B12 أساسا وظيفته بلعب
+
+21
+00:01:51,830 --> 00:01:57,870
+دور مهم جدا في خطوتين الخطوة الأولانية بيحول
+
+22
+00:01:57,870 --> 00:02:01,690
+الميثايل مالوني الكوانزيم A إلى ساكسيني الكوانزيم 
+
+23
+00:02:01,690 --> 00:02:06,070
+A وهذه خطوة مهمة جدا في تصنيع الهيموجلوبين بل
+
+24
+00:02:06,070 --> 00:02:10,830
+بالعكس بيعتبروها rate limiting step الخطوة الثانية
+
+25
+00:02:10,830 --> 00:02:15,010
+أو الحاجة الثانية اللي بلعب دور فيها بشكل أساسي هو
+
+26
+00:02:15,010 --> 00:02:19,130
+تحويل ال homocysteine إلى Methionine وهذه خطوة
+
+27
+00:02:19,130 --> 00:02:22,750
+أيضا تتحقق
+
+28
+00:02:23,270 --> 00:02:30,350
+أثناء تصنيع الفولك أسد وهذا هما شريحتين هما هوموسيستين
+
+29
+00:02:30,350 --> 00:02:36,130
+الميثيونين بيحولها مثال كوبالأمين كوبالأمين هو اسم
+
+30
+00:02:36,130 --> 00:02:41,150
+ال vitamin B12 والمثايل مالوني الكوانزين A إلى
+
+31
+00:02:41,150 --> 00:02:47,010
+سكسيني الكوانزين A بواسطة أدنوزين كوبالأمين الثاني
+
+32
+00:02:47,010 --> 00:02:52,780
+زي بعض بس وقعد في مثال جروب وقعد فيه أدنوزين 
+ 
+33
+00:02:52,780 --> 00:02:59,160
+requirement of vitamin B12 طبعا بداية أن هو ال
+
+34
+00:02:59,160 --> 00:03:02,700
+main source of vitamin B12 is dietary يعني أنحن
+
+35
+00:03:02,700 --> 00:03:05,880
+لازم ناخده عن طريق الأكل و بنلاقيه في ال liver و ال
+
+36
+00:03:05,880 --> 00:03:09,420
+kidney و ال red meats و ال eggs و ال shellfish و
+
+37
+00:03:09,420 --> 00:03:15,260
+ال dairy products بشكل عام ال maximum diet
+
+38
+00:03:15,260 --> 00:03:18,760
+contained يعني أكل نشريقي بيحتوي على خمسة إلى
+
+39
+00:03:18,760 --> 00:03:23,980
+ثلاثين microgram في اليوم and vitamin B12 is
+
+40
+00:03:23,980 --> 00:03:29,320
+relatively stable بمعنى لا نفقد منه كثيرا أثناء
+
+41
+00:03:29,320 --> 00:03:36,080
+عملية الطبخ نفقد منه واحد إلى أربعة microgram في
+
+42
+00:03:36,080 --> 00:03:44,080
+اليوم طبعا الاختلافات أنهم يخسروا خصوصا في الهواء
+
+43
+00:03:44,080 --> 00:03:49,720
+والجلد وبما أنه ما فيش consumption لل vitamin B12
+
+44
+00:03:49,720 --> 00:03:55,000
+يبقى ال daily requirement بتساوي ال daily losses
+
+45
+00:03:55,000 --> 00:04:00,040
+يعني احنا احنا بنحتاج إلى واحد إلى أربعة microgram 
+
+46
+00:04:00,040 --> 00:04:05,160
+daily وعنا في الأكل كمية كبيرة بتوصل من خمسة
+
+47
+00:04:05,160 --> 00:04:09,020
+إلى ثلاثين microgram ففينا excess of vitamin B12 in
+
+48
+00:04:09,020 --> 00:04:16,060
+our diet stores وجدوا أن ال stores بقيمتها أو
+
+49
+00:04:16,060 --> 00:04:21,040
+بتساوي ثلاثة إلى أربعة milligram من vitamin B12 في
+
+50
+00:04:21,040 --> 00:04:26,200
+الجسم مخزنة في ال liver وهذه الكمية بتكفينا إلى 
+
+51
+00:04:26,200 --> 00:04:31,090
+ثلاث سنوات وفي بعض المراجع بتقول تكفي لسبع سنوات
+
+52
+00:04:31,090 --> 00:04:35,730
+من بعد ما توقف أخذ vitamin B12 يعني يوم ما توقف
+
+53
+00:04:35,730 --> 00:04:40,070
+أخذ ال vitamin B12 في عندك reserve في عندك احتياطي
+
+54
+00:04:40,070 --> 00:04:47,370
+مخزون بكفيك لسنوات كيف يمتص؟ الامتصاص هي عبارة عن
+
+55
+00:04:47,370 --> 00:04:50,910
+active process عملية ال absorption و بتتم في ال
+
+56
+00:04:50,910 --> 00:04:58,550
+ileum وببساطة خطوات سيرها هي كالتالي بتاكل الأكل
+
+57
+00:04:58,550 --> 00:05:02,950
+بيخش ال vitamin B12 على ال gas على ال stomach و
+
+58
+00:05:02,950 --> 00:05:07,950
+هناك فيه gastric and duodenal enzyme بتروحه هي
+
+59
+00:05:07,950 --> 00:05:12,830
+رابطة ال vitamin B12 اللي تحرر من الأكل ب
+
+60
+00:05:12,830 --> 00:05:16,610
+intrinsic factor بنسبة واحد إلى واحد و ال
+
+61
+00:05:16,610 --> 00:05:20,150
+intrinsic factor هو عبارة عن factor عبارة عن
+
+62
+00:05:20,150 --> 00:05:24,330
+glycoprotein و ال clear weight تبعه 45000 و يصنع 
+
+63
+00:05:24,330 --> 00:05:27,650
+في ال gastric parietal cell يعني اللي
+
+64
+00:05:27,650 --> 00:05:33,330
+بتصنعه هي الاستمك فبصير عندنا complex من ال vitamin B12 و
+
+65
+00:05:33,330 --> 00:05:38,830
+ال intrinsic factor بنزل على الأمعاء و دل
+
+66
+00:05:38,830 --> 00:05:42,470
+يمشي لغاية مسل ال ileum و هناك في receptor في ال
+
+67
+00:05:42,470 --> 00:05:49,240
+ileum ل this complex موجودة في ال ileal mucosal
+
+68
+00:05:49,240 --> 00:05:55,200
+cell فبرطبط فيها وعملت ارتباطه مشروطة بوجود
+
+69
+00:05:55,200 --> 00:06:01,520
+الكالسيوم ايونز و ال neutral pH فبصير بعد هيك
+
+70
+00:06:01,520 --> 00:06:06,900
+internalization لل complex مع ال receptor وصله
+
+71
+00:06:06,900 --> 00:06:10,740
+release في ال portal circulation و غالبا بصل بعد
+
+72
+00:06:10,740 --> 00:06:17,110
+ست ساعات من الأكل إلى وصل الدم كيف ينقل إلى أماكن
+
+73
+00:06:17,110 --> 00:06:22,790
+استخدامه وأماكن تخزينه في حال عدم استخدامه جاله
+
+74
+00:06:22,790 --> 00:06:25,910
+فيه ثلاثة نواقل أساسية Transcobalamin سموها Transcobalamin
+
+75
+00:06:25,910 --> 00:06:29,950
+واحد و اثنين و ثلاثة 
+
+76
+00:06:29,950 --> 00:06:34,770
+و ال significant ال physiological active فيهم هو
+
+77
+00:06:34,770 --> 00:06:42,280
+اثنين بتبطط مع ال vitamin B12 بنسبة واحد إلى واحد و
+
+78
+00:06:42,280 --> 00:06:48,280
+طبعا هذا ال complex بتاخد transcobalamin مع ال
+
+79
+00:06:48,280 --> 00:06:53,560
+vitamin بيضل يمشي لغاية ما يصل إلى ال surface
+
+80
+00:06:53,560 --> 00:06:58,320
+receptor اللي موجودة على developing blood cell في
+
+81
+00:06:58,320 --> 00:07:03,760
+ال bone marrow يعني احنا بدنايا لبناء الخلايا و
+
+82
+00:07:03,760 --> 00:07:09,470
+بعد هناك هناك يصير في hydrolysis لل vitamin فبنزل
+
+83
+00:07:09,470 --> 00:07:13,870
+بنفك عن ال Transcobalamine و بفجر Transcobalamine
+
+84
+00:07:13,870 --> 00:07:21,270
+2 عشان يحمل واحد ثاني أو vitamin B12 molecule ثاني 
+
+85
+00:07:21,270 --> 00:07:24,490
+العملية
+
+86
+00:07:24,490 --> 00:07:28,370
+هذه طبعا نسميها Physiologically Active Process
+
+87
+00:07:28,370 --> 00:07:33,450
+لأنها سريعة Transcobalamine بيوصل ال half-life
+
+88
+00:07:33,450 --> 00:07:36,970
+تبعته يعني اثنتي عشر ساعة يعني بيوصل ال vitamin ل developing cell within twelve hours و هي بالتالي
+
+89
+00:07:36,970 --> 00:07:40,510
+غيابها بيعمل megaloplastic anemia within weeks of
+
+90
+00:07:47,590 --> 00:07:52,090
+birth بينما ال transcobalamin واحد و ثلاثة they
+
+91
+00:07:52,090 --> 00:07:57,530
+are alpha globulin و يصنعوا في ال white blood cell
+
+92
+00:07:57,530 --> 00:08:04,520
+granules and they are known as R binders وموجودين
+
+93
+00:08:04,520 --> 00:08:08,760
+في عدد هائل من ال blood fluid اللي موجودة في الجسم
+
+94
+00:08:08,760 --> 00:08:14,540
+ووجدوا أن transcobalamin واحد و ثلاثة مش زي
+
+95
+00:08:14,540 --> 00:08:21,690
+اثنين ما بيوصلوا ال vitamin ل ال developing cell
+
+96
+00:08:21,690 --> 00:08:27,390
+before twelve days يعني بدهم اثني عشر يوم عشان
+
+97
+00:08:27,390 --> 00:08:34,210
+يكسبوهم R binders مرتبطين بالويتامين بقوة ومن هذا
+
+98
+00:08:34,210 --> 00:08:39,270
+المنطلق ال congenital absence لهذه الحوائل الروابط
+
+99
+00:08:39,270 --> 00:08:45,330
+اللي هي ال transporter ما بيعمل يعني has no
+
+100
+00:08:45,330 --> 00:08:47,770
+physiological impairment يعني ما بيعمل
+
+101
+00:08:47,770 --> 00:08:52,800
+megaloplastic و هذه الصورة هي ال vitamin B12 دخل مع
+
+102
+00:08:52,800 --> 00:08:56,140
+الأكل صار له liberation فى ال stomach فيه في ال
+
+103
+00:08:56,140 --> 00:08:59,900
+stomach intrinsic factor ارتبط بال vitamin B12 
+
+104
+00:08:59,900 --> 00:09:03,720
+وصار في عندنا vitamin B12 intrinsic factor complex اللي
+
+105
+00:09:03,720 --> 00:09:09,040
+هينزل في الأمعاء و هناك في ال ileum ده هو فيه
+
+106
+00:09:09,040 --> 00:09:12,820
+receptor لهذا ال complex فبرتبط في ال receptor و
+
+107
+00:09:12,820 --> 00:09:18,360
+بيصير internalization لل receptor مع ال complex و
+
+108
+00:09:18,360 --> 00:09:25,280
+بيخش على ال portal circulation as طبعا يعني هو ال
+
+109
+00:09:25,280 --> 00:09:30,620
+complex و هناك بيسموه hydrolysis فبيفقن من ال .. من
+
+110
+00:09:30,620 --> 00:09:35,580
+ال .. من ال complex و بيصير free فبيتلقفوا من
+
+111
+00:09:35,580 --> 00:09:39,520
+الحامل و هو transcobalamin two اللي بياخدوا و
+
+112
+00:09:39,520 --> 00:09:43,940
+بيودّي على وين أي delivery to the tissue اللي
+
+113
+00:09:43,940 --> 00:09:48,360
+اتفقنا عليها سواء كانت في ال bone marrow أو في
+
+114
+00:09:48,360 --> 00:09:54,830
+المخازن نفس الصورة تشرح نفس الحكاية هذا ما يتعلق
+
+115
+00:09:54,830 --> 00:10:01,410
+بال vitamin B12 الفوليت الفوليت
+
+116
+00:10:01,410 --> 00:10:13,130
+أسيد هو ال parent او فوليت و زي ما أنتم شايفين ال
+
+117
+00:10:13,130 --> 00:10:18,230
+structure تبعه مبين و كمان الإنسان لا يستطيع تصنيعه
+
+118
+00:10:18,230 --> 00:10:24,190
+وبالتالي مصدره الأساسي هو الأكل دوره بلعب دور كبير
+
+119
+00:10:24,190 --> 00:10:29,190
+as a single carbon donor acceptor بيعطي و بياخد
+
+120
+00:10:29,190 --> 00:10:34,970
+ذرة carbon طبعا متمثلة في ال methyl group و شوفوا هذه
+
+121
+00:10:34,970 --> 00:10:39,730
+الوظائف الخمسة تبعته مرة واحدة synthesis of
+
+122
+00:10:39,730 --> 00:10:46,430
+methionine كيف جالوا بيعطي methyl group من ال N5
+
+123
+00:10:46,430 --> 00:10:47,930
+methyl tetrahydrofolate
+
+124
+00:10:51,290 --> 00:10:57,190
+وبالتالي its form 
+
+125
+00:10:57,190 --> 00:11:00,070
+الميثيونين بيتكوّن و طبعا ال vitamin B12 في هذا
+
+126
+00:11:00,070 --> 00:11:04,990
+الحالة بيكون as coenzyme يعني الفولك أسد هو الأساس
+
+127
+00:11:04,990 --> 00:11:09,630
+في عملية تصنيع الميثيونين لكن يحتاج إلى ال vitamin
+
+128
+00:11:09,630 --> 00:11:16,430
+B12 as a coenzyme بيسمى purin و pyrimidine و هذه
+
+129
+00:11:16,430 --> 00:11:21,890
+خطوات مهمة جدا في تصنيع ال DNA ثم conversion of
+
+130
+00:11:21,890 --> 00:11:27,990
+serine into glycine واخر واحدة هستدين كتابولزم
+
+131
+00:11:27,990 --> 00:11:36,530
+و هذه هي ال cycles اللي بيتمثل ال metabolic pathway 
+
+132
+00:11:36,530 --> 00:11:43,590
+of folic acid في عندنا cycle أساسية هذه هي تبدأ
+
+133
+00:11:43,590 --> 00:11:49,680
+بال N5-methyltetrahydrofolate تتحول إلى
+
+134
+00:11:49,680 --> 00:11:56,040
+Tetrahydrofolate طبعا هذا في وجود vitamin B12 في 
+
+135
+00:11:56,040 --> 00:11:59,720
+ال homocysteine بتتحول لميثيونين ثم
+
+136
+00:11:59,720 --> 00:12:04,040
+Tetrahydrofolate تتحول
+
+137
+00:12:04,040 --> 00:12:09,500
+إلى N5 N10 methylene Tetrahydrofolate وأيضا في هذا
+
+138
+00:12:09,500 --> 00:12:13,240
+الخطوة ده هو تتحقق اللي هو تحول السيرين إلى glycine
+
+139
+00:12:13,240 --> 00:12:20,880
+ثم بعد ذلك ل N5 N10 بيتحول ل Dihydrofolate على جانب 
+
+141
+00:12:20,880 --> 00:12:27,220
+هذا التفاعل بيتم تصنيع الـ DHF إلى THF من الـ DHF و
+
+142
+00:12:27,220 --> 00:12:31,680
+طبعا هذه خطوة مهمة في تصنيع الـ DNA والRNA اللي 
+
+143
+00:12:31,680 --> 00:12:36,340
+بعد هيك ال Dihydrofolate بيتحول ل Tetrahydrofolate 
+
+144
+00:12:36,340 --> 00:12:40,360
+مرة تانية بوسط ال Dihydrofolate Reductase Enzyme 
+
+145
+00:12:40,360 --> 00:12:45,220
+في ال cycle التحتنية هذه احنا هنا هنتحول
+
+146
+00:12:45,220 --> 00:12:49,940
+الهوموسيستين لميثيونين تحول السيرين إلى جليسين ثم 
+
+147
+00:12:49,940 --> 00:12:57,060
+في DNA ماشي وRNA synthesis هي أربع وظائف ولو جينا
+
+148
+00:12:57,060 --> 00:13:01,600
+للساكل الفجنية دي هوموشستين بتحول لميثيونين و
+
+149
+00:13:01,600 --> 00:13:07,200
+الادينوزيل ميثيونين بيتحول بعد هي ل S-adenosyl
+
+150
+00:13:07,200 --> 00:13:10,720
+-homocysteine اللي بعد هي بتتحول لهوموسيستين مرة
+
+151
+00:13:10,720 --> 00:13:15,810
+ثانية تحول الهوموسيستين الى ميثيونين تحول 
+
+152
+00:13:15,810 --> 00:13:19,810
+الهوموسيستين الى ميثيونين تحول الهوموسيستين الى
+
+153
+00:13:19,810 --> 00:13:25,570
+ميثيونين تحول الهوموسيستين الى ميثيونين تحول
+
+154
+00:13:25,570 --> 00:13:27,710
+الهوموسيستين الى ميثيونين تحول الهوموسيستين الى
+
+155
+00:13:27,710 --> 00:13:28,250
+ميثيونين تحول الهوموسيستين الى ميثيونين تحول
+
+156
+00:13:28,250 --> 00:13:31,090
+الهوموسيستين الى ميثيونين تحول الهوموسيستين الى
+
+157
+00:13:31,090 --> 00:13:31,330
+الهوموسيستين الى ميثيونين تحول الهوموسيستين الى
+
+158
+00:13:31,330 --> 00:13:36,010
+ميثيونين تحول الهوموسيستين الى ميثيونين تحول
+
+159
+00:13:41,440 --> 00:13:45,900
+daily our requirement of folic acid and storage
+
+160
+00:13:45,900 --> 00:13:51,160
+دلوقت لنا اليوم فيه 100 مايكرو في دراعهم طبعا 
+
+161
+00:13:51,160 --> 00:13:54,880
+mainly بنفقدها
+
+162
+00:13:56,850 --> 00:14:01,630
+سواء بيه؟ تاكر اليوم؟ يا اللي جيتها نشوف فيه كتير
+
+163
+00:14:01,630 --> 00:14:08,250
+فيه سبعمائة daily احنا بنفقد daily في ال meet
+
+164
+00:14:08,250 --> 00:14:11,750
+microgram من ال folic acid غالبا بنفقدها في 
+
+165
+00:14:11,750 --> 00:14:16,770
+الفيسر والارانب والسويد ماشيووجدوا ان الفيسر في 
+
+166
+00:14:16,770 --> 00:14:20,110
+كميات كبيرة من ال vitamin B12 و ال folic acid لكن
+
+167
+00:14:20,110 --> 00:14:23,650
+مش من الأكل هذه جاية من ال normal microbial flora
+
+168
+00:14:23,650 --> 00:14:27,650
+activity اللي موجودة في ال .. في ال ايش؟ في ال ..
+
+169
+00:14:27,650 --> 00:14:34,330
+ال stool وبالتالي لا يستفد منها لأنها تصنع بعد 
+
+170
+00:14:34,330 --> 00:14:36,850
+مواقع امتصاص ال folic acid
+
+171
+00:14:41,220 --> 00:14:50,520
+لكن عشان نحافظ على مخازن الفوليك أسيد مليانة لازم ال
+
+172
+00:14:50,520 --> 00:14:56,440
+normal other requirement تكون في حدود ما يفقد وهي
+
+173
+00:14:56,440 --> 00:15:02,060
+الـ 100 ميكرو جرام ماشي تخزن هذه الكمية mainly في 
+
+174
+00:15:02,060 --> 00:15:06,210
+ال liverو الفوليك أسيد بشكل عام موجود في ال leafy
+
+175
+00:15:06,210 --> 00:15:11,210
+vegetable اللي هو ال grains في ال yeast but it's
+
+176
+00:15:11,210 --> 00:15:15,870
+الفوليك أسيد بحيث ذاته is extremely sensitive to 
+
+177
+00:15:15,870 --> 00:15:22,510
+heat عشان هيك عملية الطبخ بالطويلة بتفقد كمية 
+
+178
+00:15:22,510 --> 00:15:29,190
+كبيرة منهو ببساطة الميت مايكرو جرام اللى بنحتاجها 
+
+179
+00:15:29,190 --> 00:15:33,250
+يومى بناخدها من الأكل اللى فى كمية كبيرة بتوصل لـ
+
+180
+00:15:33,250 --> 00:15:37,850
+700 مايكرو جرام لكن للأسف الشديد زى ما قلنا لكوا مع 
+
+181
+00:15:37,850 --> 00:15:44,270
+الطبخ برلود cooking بيأدى لفقدان كميات كبيرة من 
+
+182
+00:15:44,270 --> 00:15:53,770
+الفوليك أسيد و مهما نفقد بيظل كمية تقريبا بتساوي 
+
+183
+00:15:53,770 --> 00:16:03,230
+ما نحتاجه يوميا مخازن الفوليك أسيد فى الجسم تحتوي
+
+184
+00:16:03,230 --> 00:16:03,890
+على عشرة
+
+185
+00:16:09,630 --> 00:16:15,180
+لكن لو كان الفوليك أسيد فهو ممكن يخزن في الفريك بهذه
+
+186
+00:16:15,180 --> 00:16:19,660
+الكمية المخزون الفوليك أسيد بهذه الكمية لا يكفينا
+
+187
+00:16:19,660 --> 00:16:27,380
+إلا إلى تلاتة إلى أربع شهور بعد توقف امتصاص أو أخذ
+
+188
+00:16:27,380 --> 00:16:32,140
+الفوليك أسيد وهذه فترة حرجة جدا وخصوصا في
+
+189
+00:16:32,140 --> 00:16:37,100
+البرجنانسي لأن البرجنانسي فترته تسعة شهور واحنا
+
+190
+00:16:37,100 --> 00:16:44,390
+مخازينا لا تكفينا إلا إلى تلت شهور كيف امتصاصه هو
+
+191
+00:16:44,390 --> 00:16:49,630
+يمتص في الأعضاء الـ Digital وغالبا بيتحول الفولي
+
+192
+00:16:49,630 --> 00:16:52,910
+عشان يمتص بيتحول ال polyglutamate folic acid أو
+
+193
+00:16:52,910 --> 00:17:00,130
+folate الى monoglutamate قبل الامتصاص و بعد ما
+
+194
+00:17:00,130 --> 00:17:03,730
+بيخش as monoglutamate بيتحول لأنفع مثال 
+
+195
+00:17:03,730 --> 00:17:07,290
+tetrahydrofolate اللي بعد هيك بيصلها releasing في
+
+196
+00:17:07,290 --> 00:17:13,490
+ال portal circulation والـ folate usually
+
+197
+00:17:13,490 --> 00:17:18,990
+circulates freely أو بعض المرات بيكون مرتبط مع 
+
+198
+00:17:18,990 --> 00:17:27,950
+plasma protein يعني الناقل لل folate still is
+
+199
+00:17:27,950 --> 00:17:35,330
+unknown بيقول انه عادة بيcirculate freely في الدم
+
+200
+00:17:35,330 --> 00:17:40,910
+أو بيكون مرتبط ببعض البروتينات وفي بعض الدلائل
+
+201
+00:17:41,440 --> 00:17:47,540
+العلمية اللى بتقول انه there is transport protein
+
+202
+00:17:47,540 --> 00:17:52,780
+for folic acid وإنه في غياب ال folic acid this
+
+203
+00:17:52,780 --> 00:17:59,720
+protein is increased لإنه لم يُشتغل لإنه لم يُشتغل
+
+204
+00:17:59,720 --> 00:18:03,780
+أبي مقدّم سريعًا folic acid و vitamin B12 واخدنا 
+
+205
+00:18:03,780 --> 00:18:08,160
+ال chemistry of both ونتطبق الآن إلى ال
+
+206
+00:18:08,160 --> 00:18:13,340
+megaloblastic anemia اللي هي غالبا ناتجة عن
+
+207
+00:18:13,340 --> 00:18:19,080
+deficiency of both  نجال ال plastic anemia تعريفا 
+
+208
+00:18:19,080 --> 00:18:26,020
+هي عبارة عن pan hypoplastic disorder شو يعني pan
+
+209
+00:18:26,020 --> 00:18:32,380
+hypoplastic disorder pan معناتها كل وhypo معناتها
+
+210
+00:18:32,380 --> 00:18:40,310
+قلة و plastic تصنيع يعني صار فيه قلة في تصنيع كل
+
+211
+00:18:40,310 --> 00:18:47,250
+الخلايا في البودمارون بيسمو المصطلح panhypoplastic 
+
+212
+00:18:47,250 --> 00:18:51,150
+disorder and it's usually characterized by 
+
+213
+00:18:51,150 --> 00:18:54,150
+retardation of DNA synthesis طبيعي جدا مازال مافيش
+
+214
+00:18:54,150 --> 00:18:57,250
+vitamin بتول مش راح يستثمر اللي هو ال DNA و
+
+215
+00:18:57,250 --> 00:19:01,230
+الRNA و ال folic acid طبعا وبالتالي ما بيصير
+
+216
+00:19:01,230 --> 00:19:09,120
+فيه تطور مش راح يتصنع ال DNA وبالتالي مافي تطور 
+
+217
+00:19:09,120 --> 00:19:13,700
+للنكليز وبيصير فيه retardation of DNA synthesis
+
+218
+00:19:13,700 --> 00:19:18,440
+لكن بالمناسبة ال RNA بتتم تصنيعه في ال cytoplasm
+
+219
+00:19:18,440 --> 00:19:22,780
+وبالتالي ال cytoplasm بيستمر في التطور فبيصير فيه
+
+220
+00:19:22,780 --> 00:19:27,640
+نوع من ال asynchronous عدم التوافق ما بين نمو
+
+221
+00:19:27,640 --> 00:19:31,540
+النواء وما بين نمو ال cytoplasm
+
+222
+00:19:34,570 --> 00:19:40,490
+بيسموا هذه الحالة Asynchronism أو Asynchronous
+
+223
+00:19:40,490 --> 00:19:45,550
+status ما بين Nuclear and cytoplasmic maturation
+
+224
+00:19:45,550 --> 00:19:51,270
+وطبعا هذه هي المسئولة عن ال Distinct morphological
+
+225
+00:19:51,270 --> 00:19:54,170
+and biochemical feature تبعت الميجالو
+
+226
+00:19:54,170 --> 00:20:00,170
+بلاستيكالينيا أسبابها قلنا اما vitamin B12 أو
+
+227
+00:20:00,170 --> 00:20:04,270
+folic acid deficiency أو sometimes both الاتنين
+
+228
+00:20:04,270 --> 00:20:11,250
+بيكونوا معاهم ويوجدوا انه في اسباب اخرى زى ما
+
+229
+00:20:11,250 --> 00:20:15,250
+قلنالكوا غير ال vitamin b12 و ال folic acid ان 
+
+230
+00:20:15,250 --> 00:20:21,830
+شاء الله بنتطرق اليها طبعا نشوف أولا أسباب نقص ال
+
+231
+00:20:21,830 --> 00:20:26,410
+vitamin B12 في البصمة نقول فيها أنها أربع أسباب
+
+232
+00:20:26,410 --> 00:20:36,310
+أساسية وهي ببساطة زي أي Nutritional component بأسباب
+
+233
+00:20:36,310 --> 00:20:42,630
+نقصه بيندرج تحت القاتل نمرا واحد أنه بيكون الأكل
+
+234
+00:20:42,630 --> 00:20:48,980
+مش فيه vitamin نمرا اتنين بيكون الأكل محتوي على ال
+
+235
+00:20:48,980 --> 00:20:52,320
+vitamin لكن فيه intestinal malabsorption ماعب
+
+236
+00:20:52,320 --> 00:20:57,820
+نمطسه نمرة تلاتة أخدنا ال vitamin من الأكل و
+
+237
+00:20:57,820 --> 00:21:04,400
+نمطسناه لكن في زيادة في الطلب عليه بكميات
+
+238
+00:21:04,400 --> 00:21:12,750
+أكبر من ما يمتص نمرة اربعة خدنا ال vitamin وامتتصنا
+
+239
+00:21:12,750 --> 00:21:20,990
+ودخل الجسم بكميات مطلوبة لكن الجسم فشل في استغلاله
+
+240
+00:21:20,990 --> 00:21:26,350
+وفي استهلاكه لل vitamin يعني مافيش استغلال جيد لل
+
+241
+00:21:26,350 --> 00:21:30,030
+vitamin ونشوف هذه الأسباب نمرة واحد inadequate
+
+242
+00:21:30,030 --> 00:21:33,390
+dietary intake واتفقنا على انه it's uncommon cause
+
+243
+00:21:33,390 --> 00:21:37,310
+للأسباب التالية نمرة واحد قولنا ان الأكل موجود
+
+244
+00:21:37,310 --> 00:21:41,870
+بكميات كبيرة في أكلنا الشرقي ونمرة اتنين it's 
+
+245
+00:21:41,870 --> 00:21:46,050
+relatively heat stable ما بنفقده أثناء ال cooking
+
+246
+00:21:46,050 --> 00:21:50,550
+نمرة تلاتة مخزونة بيكفينا إلى سنوات at least for 
+
+247
+00:21:50,550 --> 00:21:56,700
+three years ماشي بعد ما نوقف اخد اللي هو ال vitamin
+
+248
+00:21:56,700 --> 00:22:02,240
+تماما ما ال absorption and this is common وطبعا 
+
+249
+00:22:02,240 --> 00:22:07,540
+على عكس ذات لسبب الأولاني قالوا اسبابها ممكن تكون
+
+250
+00:22:07,540 --> 00:22:12,060
+lack of intrinsic factor مفيش مفيش امتصاص صح طبعا 
+
+251
+00:22:12,060 --> 00:22:15,200
+اذا مافيش امتصاص قالوا اسباب كالقاتى lack of
+
+252
+00:22:15,200 --> 00:22:20,300
+intrinsic factor which is important مفيش intrinsic
+
+253
+00:22:20,300 --> 00:22:24,240
+factor يبقى مافيش تكوين لل complex من أصله
+
+254
+00:22:24,240 --> 00:22:29,500
+gastrointestinal disease في حالة مرضية في الجهاز
+
+255
+00:22:29,500 --> 00:22:34,480
+الهضمي و ال drug induced mal absorption دخل علاج 
+
+256
+00:22:34,480 --> 00:22:38,960
+عمل blocking لل absorption of vitamin B12 و نبدأ
+
+257
+00:22:38,960 --> 00:22:42,520
+في أول هذه الأسباب و هي lack of intrinsic factor و
+
+258
+00:22:42,520 --> 00:22:48,550
+بعمل قانينة مميزة سموها pernicious anemia وهي
+
+259
+00:22:48,550 --> 00:22:52,550
+megaloblastic megaloblastic
+
+260
+00:22:52,550 --> 00:22:56,590
+anemia لكن الانيميا اللي ناجي عن نقص ال 
+
+261
+00:22:56,590 --> 00:23:02,390
+intrinsic factor بسموها pernicious anemia and it's 
+
+262
+00:23:02,390 --> 00:23:06,070
+by far the most common cause of B12 deficiency
+
+263
+00:23:06,070 --> 00:23:12,150
+ووجدوا انها موجودة بنسبة عالية بتوصل لـ 2% في الناس
+
+264
+00:23:12,150 --> 00:23:12,870
+الاختيارية
+
+265
+00:23:15,260 --> 00:23:18,480
+وغالبا associated with blood group A ناس اللي
+
+266
+00:23:18,480 --> 00:23:23,780
+فصيلة دمهم A وموجودة في ال women أكتر من الرجال من ال
+
+267
+00:23:23,780 --> 00:23:29,160
+men شو يعني بيرنيشا ثانيميا قالوا غالبا بيرنيشا
+
+268
+00:23:29,160 --> 00:23:32,380
+ثانيميا اللي بيصير فيها انه بيصير في intestinal
+
+269
+00:23:32,380 --> 00:23:36,440
+malabsorption طبعا السبب؟ قالوا في gastric
+
+270
+00:23:36,440 --> 00:23:42,700
+atrophy للميوكوزل البرايتل سيل اللي بتصنع ال 
+
+271
+00:23:42,700 --> 00:23:48,810
+intrinsic factor في ال stomach وحديثا بوضعوا بعض 
+
+272
+00:23:48,810 --> 00:23:52,030
+النظريات بتقول انه في علاقة ما بين ال autoimmune
+
+273
+00:23:52,030 --> 00:23:59,790
+disease و ال pernicious anemia و
+
+274
+00:23:59,790 --> 00:24:05,700
+أثبتوا هذا الكلام بعد ما اعطوا كورتيكوستيرويد
+
+275
+00:24:05,700 --> 00:24:11,320
+therapy والكورتيكوستيرويد therapy بتعمل suppression 
+
+276
+00:24:11,320 --> 00:24:15,080
+لل immune response ففي حالة ال autoimmune لو عملنا
+
+277
+00:24:15,080 --> 00:24:20,700
+suppression لل immune response احنا بنحسن حالة
+
+278
+00:24:20,700 --> 00:24:24,720
+المريض وفي هذه الحالة تحسن مريض ال pernicious
+
+279
+00:24:24,720 --> 00:24:26,980
+anemia يوم ما اعطينا كورتازون
+
+280
+00:24:30,300 --> 00:24:34,740
+هناك اقتراح ان هناك علاقة بين الهيليوكوباكتر 
+
+281
+00:24:34,740 --> 00:24:40,940
+ايلوري و البرنيشا ثانيميا لكن كل الأبحاث التي تمت
+
+282
+00:24:40,940 --> 00:24:48,080
+نفت هذا الاختيار في البرنيشا ثانيميا ما يميزها أن
+
+283
+00:24:48,080 --> 00:24:54,840
+90% من المرضى عندهم cytotoxic IgG واسمه cytotoxic
+
+284
+00:24:54,840 --> 00:24:59,710
+يعني أنه toxic للخلايا التي يرتبط فيها. طيب موجه
+
+285
+00:24:59,710 --> 00:25:04,670
+لمين؟ قالوا موجه للـ gastric parietal cell أو للـ
+
+286
+00:25:04,670 --> 00:25:09,030
+intrinsic factor التي تصنعها الـ parietal cell أين؟
+
+287
+00:25:09,030 --> 00:25:16,010
+في الـ serum. يبقى 90% من المرضى عندهم IgG which can
+
+288
+00:25:16,010 --> 00:25:20,990
+block either the parietal cell or the intrinsic
+
+289
+00:25:20,990 --> 00:25:26,890
+factor التي تصنعها الـ parietal cell.  كمان وجدوا أن في
+
+290
+00:25:26,890 --> 00:25:31,730
+75% من المرضى أن الأنتيبادي هذا موجود في الـ
+
+291
+00:25:31,730 --> 00:25:34,910
+gastric juice  مش في الـ serum. آه في الـ gastric 
+
+292
+00:25:34,910 --> 00:25:38,890
+juice وكمان
+
+293
+00:25:38,890 --> 00:25:46,390
+وجدوا أنه في polyclonal IgG و IgA in
+
+294
+00:25:46,390 --> 00:25:51,830
+both serum and gastric juice لكن بنسبة أيش؟ 50% من
+
+295
+00:25:51,830 --> 00:25:56,420
+المرضى. يبقى 90% من المرضى عندهم Antibody في الـ
+
+296
+00:25:56,420 --> 00:26:00,040
+Serum و 75% من المرضى عندهم Antibody في الـ
+
+297
+00:26:00,040 --> 00:26:04,680
+Gastric Juice و 50% من المرضى عندهم both IgG و IgA
+
+298
+00:26:04,680 --> 00:26:10,620
+in both Serum و Gastric Juice. كيف
+
+299
+00:26:10,620 --> 00:26:15,880
+يشتغل هذا الـ Antibody؟ قالوا إما بمنع ارتباط الـ
+
+300
+00:26:15,880 --> 00:26:20,060
+Vitamin B12 بالـ Intrinsic Factor وفي هذه الحالة
+
+301
+00:26:20,060 --> 00:26:25,830
+بسموه Type I Antibody، وإما بعمل Inhibition للـ
+
+302
+00:26:25,830 --> 00:26:32,450
+absorption of complex وفي 
+
+303
+00:26:32,450 --> 00:26:35,290
+هذه الحالة بيسموه type 2 antibody.
+
+304
+00:26:39,730 --> 00:26:43,950
+بيثبت أنه لها علاقة بإيش؟ بالـ autoimmune disease
+
+305
+00:26:43,950 --> 00:26:48,050
+وجدوها في كثير من حالات الـ autoimmune disease زي
+
+306
+00:26:48,050 --> 00:26:51,430
+الـ autoimmune thyroid disease والـ rheumatoid
+
+307
+00:26:51,430 --> 00:26:56,950
+arthritis والـ gastric carcinoma، وبالتالي في علاقة
+
+308
+00:26:56,950 --> 00:27:02,270
+ما بين الـ autoimmune والـ هذه والـ pernicious 
+
+309
+00:27:02,270 --> 00:27:07,990
+anemia. ووجدوا فيه نوع نادر، النوع النادر هذا غالبا
+
+310
+00:27:08,640 --> 00:27:11,360
+associated with congenital deficiency بيكون فيه
+
+311
+00:27:11,360 --> 00:27:14,540
+غياب Congenitally للـ factor اللي هو الـ intrinsic
+
+312
+00:27:14,540 --> 00:27:21,360
+factor، أو أنه يصنع لكنه يصنع Dysfunctional يعني مش 
+
+313
+00:27:21,360 --> 00:27:26,700
+شغال. فكده يرتبط، وهذه الـ pernicious يعني أنّه في
+
+314
+00:27:26,700 --> 00:27:32,320
+الوضع الطبيعي ده هي أي في الـ membrane of gastric
+
+315
+00:27:32,320 --> 00:27:37,340
+stomach. ده هي وهي الـ parietal cell كلها موجودة
+
+316
+00:27:37,820 --> 00:27:41,180
+وطبعا إذا كانت موجودة بتصنع acid وهو الـ
+
+317
+00:27:41,180 --> 00:27:46,960
+hydrochloric acid وبتصنع الـ intrinsic factor. ماشي.
+
+318
+00:27:46,960 --> 00:27:50,720
+لكن في الـ parietal cell مافيش parietal cell صار
+
+319
+00:27:50,720 --> 00:27:56,500
+atrophy للـ parietal cell، وبالتالي صار في a
+
+320
+00:27:56,500 --> 00:28:00,260
+-chlorohydra يعني مافيش تصنيع للـ hydrochloric acid
+
+321
+00:28:00,260 --> 00:28:08,290
+ومافي تصنيع للـ intrinsic factor. طيب كيف أنا أشخص الـ
+
+322
+00:28:08,290 --> 00:28:12,710
+بيرنيشه سالمة جالها أن أشخصها بفحص بيسموه Schilling 
+
+323
+00:28:12,710 --> 00:28:19,170
+test، وSchilling test يا بنات ويا شباب هو عبارة عن 
+
+324
+00:28:19,170 --> 00:28:28,490
+فحص بتم كالآتي: بنجيب إحنا شوية كبدة ماشي، وبنحط
+
+325
+00:28:28,490 --> 00:28:34,390
+عليها B12 لكنه radio labeled وبنطعّمه للمريض
+
+326
+00:28:35,900 --> 00:28:40,720
+وبنتتبع الـ Vitamin B12 لأنه radio-labeled ونشوفه
+
+327
+00:28:40,720 --> 00:28:45,740
+طلع
+
+328
+00:28:45,740 --> 00:28:50,040
+في الـ urine والـ feces ولا ما طلع؟ طبعا في هذه
+
+329
+00:28:50,040 --> 00:28:56,560
+الحالة هنلاقي الكمية اللي حطيناها في شوية
+
+330
+00:28:56,560 --> 00:29:02,960
+الكبدة اللي طعّمناها للمريض هتطلع زي ما هي أين؟ في الـ
+
+331
+00:29:02,960 --> 00:29:07,160
+feces. وطبعا إحنا عاملين Radio Labeling يعني اللي
+
+332
+00:29:07,160 --> 00:29:13,000
+باندور عليه مبين معروف معلم هذا 
+
+333
+00:29:13,000 --> 00:29:17,000
+الكلام بيصير في حالة البرنيشه ثانية لو كررنا
+
+334
+00:29:17,000 --> 00:29:25,660
+العملية وفي المرة الثانية حطينا الـ B12 as a
+
+335
+00:29:25,660 --> 00:29:30,560
+complex with intrinsic factor، الـ radio labeled B12
+
+336
+00:29:30,560 --> 00:29:35,450
+حطّيناه مرتبط بالـ Intrinsic factor وطعمناها للمريض، و
+
+337
+00:29:35,450 --> 00:29:42,030
+تتبعنا الـ B12 حتى يحصل فيه امتصاص، والسبب وذلك من
+
+338
+00:29:42,030 --> 00:29:51,130
+خلال عدم خروج الـ B12 في الـ folic acid وفي الـ
+
+339
+00:29:51,130 --> 00:29:57,250
+urine والـ feces. ايه ده؟ الـ Schilling test هو عبارة
+
+340
+00:29:57,250 --> 00:30:04,660
+عن فحص بتتبع من خلاله فشل الامتصاص في الـ step
+
+341
+00:30:04,660 --> 00:30:10,720
+الأولى ثم نجاح الامتصاص في الـ step الثانية في 
+
+342
+00:30:10,720 --> 00:30:15,680
+وجود الـ intrinsic factor، وبالتالي يكون السبب غياب 
+
+343
+00:30:15,680 --> 00:30:19,960
+الـ intrinsic factor. Treatment of pernicious anemia 
+
+344
+00:30:19,960 --> 00:30:26,400
+قالوا اليوم بيعطوا الـ B12 as intramuscular injection بتركيز
+
+345
+00:30:26,400 --> 00:30:31,380
+1000 ميكروجرام weekly، يوم انشخص مريض عنده 
+
+346
+00:30:31,380 --> 00:30:35,780
+megaloplastic anemia نتيجة الـ Vitamin B12 deficiency
+
+347
+00:30:35,780 --> 00:30:41,020
+بيروحوا على معتّن اللي هو one ampoule بتركيز 1000
+
+348
+00:30:41,020 --> 00:30:45,920
+ميكروجرام of Vitamin B12 weekly لغاية ما تنطلي مخازن
+
+349
+00:30:45,920 --> 00:30:51,900
+المريض. ثم بيستمر في اعطاء هذه الإبرة لكن بدل كل
+
+350
+00:30:51,900 --> 00:30:58,880
+أسبوع بندّيله كل شهر. حاولوا طبعا لأنه إنك تعطي حقنة 
+
+351
+00:30:58,880 --> 00:31:05,140
+أسبوعية لاسبوعية أو monthly يعني عملية مزعجة. فحاولوا
+
+352
+00:31:05,140 --> 00:31:12,020
+يصنعوا Oral و Intranasal B12 لكنهم لغاية الآن 
+
+353
+00:31:12,020 --> 00:31:22,160
+فشلوا في تصنيع هذا المكوّن. ماشي وخلينا نجا فهام
+
+354
+00:31:22,860 --> 00:31:27,960
+عشان أيش؟ عشان نثبت الـ ... 
diff --git a/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4_raw.srt b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0080fb78f2f8436f346236e63a4364c33df48c01
--- /dev/null
+++ b/PL9fwy3NUQKwa4p3ndzdh57YrcgOPkXNm5/wreYTFGf7j4_raw.srt
@@ -0,0 +1,1420 @@
+1
+00:00:02,700 --> 00:00:05,860
+بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوكل و
+
+2
+00:00:05,860 --> 00:00:12,440
+أجمعين كنا في السابق في محاضرة سابقة قد تطرقنا الى
+
+3
+00:00:12,440 --> 00:00:16,720
+ال nutritional anemia من خلال شرح ال iron
+
+4
+00:00:16,720 --> 00:00:20,740
+metabolic disorder و هي مثال حي على microcytic
+
+5
+00:00:20,740 --> 00:00:25,320
+hypochromic anemia و اليوم ان شاء الله سنتطرق الى
+
+6
+00:00:25,320 --> 00:00:28,940
+نوع اخر من ال nutritional anemia و هي ال
+
+7
+00:00:28,940 --> 00:00:34,950
+megaloplastic anemia ومسبباتهاwhich are mainly
+
+8
+00:00:34,950 --> 00:00:41,250
+vitamin B12 and folic acid وإن كان في أسباب أخرى
+
+9
+00:00:41,250 --> 00:00:48,290
+سنتطرق إليها أيضا الانيميا of vitamin B12 and
+
+10
+00:00:48,290 --> 00:00:54,310
+folic acid هي غالبا انيميا سموها megaloplastic
+
+11
+00:00:54,310 --> 00:01:01,460
+انيمياVitamin B12 دعونا نتطرق إلى كما تعودنا إلى
+
+12
+00:01:01,460 --> 00:01:05,040
+ال chemistry of of both vitamin B12 and folic acid
+
+13
+00:01:05,040 --> 00:01:09,940
+نبدأ بال vitamin B12 و ال vitamin B12 هو عبارة عن
+
+14
+00:01:09,940 --> 00:01:15,680
+مركب ده و قدامكوا على شريحة بيتكوّن من تلاتة main
+
+15
+00:01:15,680 --> 00:01:21,680
+structure الأولانية وهي محاطة باللون الأزرق وهي
+
+16
+00:01:21,680 --> 00:01:25,200
+عبارة عن four spiral ring هذا هي four spiral ring
+
+17
+00:01:26,230 --> 00:01:34,250
+يتوسط ال four pyrorings كوبلت أتم مرتبطة ب
+
+18
+00:01:34,250 --> 00:01:38,410
+chemical group يبقى في عندنا pyrorings و في عندنا
+
+19
+00:01:38,410 --> 00:01:44,450
+كوبلت أتم ثم في عندنا ال chemical group هذا هو
+
+20
+00:01:44,450 --> 00:01:51,830
+عبارة عن vitamin b12 أساسا وظيفته بلعب
+
+21
+00:01:51,830 --> 00:01:57,870
+دور مهم جدافي خطواتين الخطوة الأولانية بيحول
+
+22
+00:01:57,870 --> 00:02:01,690
+الميثايل مالوني الكوانزيم a إلى ساكسيني الكوانزيم
+
+23
+00:02:01,690 --> 00:02:06,070
+a وهذه خطوة مهمة جدا في تصنيع الهيموجلبين بل
+
+24
+00:02:06,070 --> 00:02:10,830
+بالعكس بيعتبروها rate limiting step الخطوة التانية
+
+25
+00:02:10,830 --> 00:02:15,010
+أو الحاجة التانية اللي بلعب دور فيها بشكل أساسي هو
+
+26
+00:02:15,010 --> 00:02:19,130
+تحويل ال homocysteine إلى Methionine وهذه خطوة
+
+27
+00:02:19,130 --> 00:02:22,750
+أيضا تحقق
+
+28
+00:02:23,270 --> 00:02:30,350
+أثناء تصنيع الفولك أسد وهذا هما شريحتين همو سيستين
+
+29
+00:02:30,350 --> 00:02:36,130
+الميثيونين بيحولها مثال كوبالأمين كوبالأمين هو اسم
+
+30
+00:02:36,130 --> 00:02:41,150
+ال vitamin B12 والمثال مالوني الكوانزين A إلى
+
+31
+00:02:41,150 --> 00:02:47,010
+سكسيني الكوانزين A بواسطة أدنوزين كوبالأمين التاني
+
+32
+00:02:47,010 --> 00:02:52,780
+زي بعض بس وقعد في مثال جروب وقعد فيه أدنوزينال
+
+33
+00:02:52,780 --> 00:02:59,160
+requirement of vitamin B12 طبعا بداية ان هو ال
+
+34
+00:02:59,160 --> 00:03:02,700
+main source of vitamin B12 is dietary يعني انحن
+
+35
+00:03:02,700 --> 00:03:05,880
+لازم ناخده عن طريق الأكل و بنلاقي في ال liver و ال
+
+36
+00:03:05,880 --> 00:03:09,420
+kidney و ال red meats و ال eggs و ال shellfish و
+
+37
+00:03:09,420 --> 00:03:15,260
+ال dairy products بشكل عامال maximum diet
+
+38
+00:03:15,260 --> 00:03:18,760
+contained يعني أكل نشرقي بيحتوي على خمسة إلى
+
+39
+00:03:18,760 --> 00:03:23,980
+تلاتين microgram في اليوم and vitamin B12 is
+
+40
+00:03:23,980 --> 00:03:29,320
+relatively stable بمعنى لا يفقد منه كثيرا أثناء
+
+41
+00:03:29,320 --> 00:03:36,080
+عملية الطبخ نفقد منه واحد لاربعة microgram في
+
+42
+00:03:36,080 --> 00:03:44,080
+اليومطبعا الاختلافات انهم خسروا خصوصا في الهواء
+
+43
+00:03:44,080 --> 00:03:49,720
+والجلد وبما انه مافيش consumption لل vitamin B12
+
+44
+00:03:49,720 --> 00:03:55,000
+يبقى ال daily requirement بتساوي ال daily losses
+
+45
+00:03:55,000 --> 00:04:00,040
+يعني احنا احنا بتحتاج الى واحد الى اربع micro gram
+
+46
+00:04:00,040 --> 00:04:05,160
+dailyوعنا في الأكل كمية كبيرة بتوصل من خمسة
+
+47
+00:04:05,160 --> 00:04:09,020
+لتلاتين microgram ففينا excess of vitamin B12 in
+
+48
+00:04:09,020 --> 00:04:16,060
+our diet stores وجدوا انه ال stores بقيمتها او
+
+49
+00:04:16,060 --> 00:04:21,040
+بتساوي تلاتة لاربعة milligram من vitamin B12 في
+
+50
+00:04:21,040 --> 00:04:26,200
+الجسم مخزنة في ال liver وهذه الكمية بتكفينا الى
+
+51
+00:04:26,200 --> 00:04:31,090
+تلات سنواتو في بعض المراجع بتقول تكفي ل سبع سنوات
+
+52
+00:04:31,090 --> 00:04:35,730
+من بعد ما توقف اخذ vitamin B12 يعني يوم ما توقف
+
+53
+00:04:35,730 --> 00:04:40,070
+اخذ ال vitamin B12 في عندك reserve في عندك احتياطي
+
+54
+00:04:40,070 --> 00:04:47,370
+مخزون بكفيك لسنوات كيف يمتص ؟ الامتصاص هي عبارة عن
+
+55
+00:04:47,370 --> 00:04:50,910
+active process عملية ال absorption و بتتم في ال
+
+56
+00:04:50,910 --> 00:04:58,550
+heliumوببساطة خطوات سيرها هي كالقاتل بتاكل الأكل
+
+57
+00:04:58,550 --> 00:05:02,950
+بخش ال vitamin B12 على ال gas على ال stomach و
+
+58
+00:05:02,950 --> 00:05:07,950
+هناك فيه gastric and duodenal enzyme بتروحه هي
+
+59
+00:05:07,950 --> 00:05:12,830
+رابطة ال vitamin B12 اللي تحرر من الأكل ب
+
+60
+00:05:12,830 --> 00:05:16,610
+intrinsic factor بنسبة واحد إلى واحد و ال
+
+61
+00:05:16,610 --> 00:05:20,150
+intrinsic factorهو عبارة عن factor عبارة عن
+
+62
+00:05:20,150 --> 00:05:24,330
+glycoprotein و ال clear weight تبعه 45000 و يصنع
+
+63
+00:05:24,330 --> 00:05:27,650
+unsecreted body gastric parietal cell يعني اللي
+
+64
+00:05:27,650 --> 00:05:33,330
+بتصنعه هي الاستمك فبصير عندنا complex من ال P12 و
+
+65
+00:05:33,330 --> 00:05:38,830
+الفقول ال intrinsic factor بنزل على الأمعاء و دل
+
+66
+00:05:38,830 --> 00:05:42,470
+يمشي لغاية مسل ال helium و هناك في receptor في ال
+
+67
+00:05:42,470 --> 00:05:49,240
+heliumلـ this complex موجودة في الـ ileal mycosal
+
+68
+00:05:49,240 --> 00:05:55,200
+cell فبرطبط فيها وعملت ارتباطه مشروطة بوجود
+
+69
+00:05:55,200 --> 00:06:01,520
+الكالسيوم ايونز و ال neutral pH فبصير بعد هيك
+
+70
+00:06:01,520 --> 00:06:06,900
+internalization لل complex مع ال receptor وصله
+
+71
+00:06:06,900 --> 00:06:10,740
+release في ال portal circulation و غالبا بصل بعد
+
+72
+00:06:10,740 --> 00:06:17,110
+ست ساعات من الأكلالى وصل الدم كيف ينقل الى اماكن
+
+73
+00:06:17,110 --> 00:06:22,790
+استخدامه واماكن تخزينه في حال عدم استخدامه جاله
+
+74
+00:06:22,790 --> 00:06:25,910
+فيه تلت نواق الأساسية Transcope سموها Transcope
+
+75
+00:06:25,910 --> 00:06:29,950
+الأمين و هي Transcope الأمين واحد و اتنين و تلاتة
+
+76
+00:06:29,950 --> 00:06:34,770
+و ال significant ال physiological active فيهم هو
+
+77
+00:06:34,770 --> 00:06:42,280
+اتنين بتبطط مع ال vitamin B12 بنسبة واحد الى واحدو
+
+78
+00:06:42,280 --> 00:06:48,280
+طبعا هذا ال complex بتاخد trans group الأمين مع ال
+
+79
+00:06:48,280 --> 00:06:53,560
+vitamin بيضل يمشي لغاية ما يصل إلى ال surface
+
+80
+00:06:53,560 --> 00:06:58,320
+receptor اللي موجودة على developing blood cell في
+
+81
+00:06:58,320 --> 00:07:03,760
+ال bone marrow يعني احنا بدنايا لبناء الخلايا و
+
+82
+00:07:03,760 --> 00:07:09,470
+بعد هناك هناك يصير في hydrolysisللـ vitamin فبنزل
+
+83
+00:07:09,470 --> 00:07:13,870
+بنفك عن ال Transcobalamine و بفجر Transcobalamine
+
+84
+00:07:13,870 --> 00:07:21,270
+2 عشان يحمل واحد تاني او vitamin B12 موليكيول تاني
+
+85
+00:07:21,270 --> 00:07:24,490
+العملية
+
+86
+00:07:24,490 --> 00:07:28,370
+هذه طبعا تسميها Physiologically Active Process
+
+87
+00:07:28,370 --> 00:07:33,450
+لأنها سريعة Transcobalamine بيوصلالـ half-life
+
+88
+00:07:33,450 --> 00:07:36,970
+تبعته يعني اتناشر ساعة يعني بيوصل ال vitamin ل ال
+
+89
+00:07:36,970 --> 00:07:40,510
+developing cell within twelve hours و هي بالتالي
+
+90
+00:07:40,510 --> 00:07:47,590
+غياب و بيعمل megaloplastic anemia within weeks of
+
+91
+00:07:47,590 --> 00:07:52,090
+birth بينما الترانسكوب الأمين واحد و تلاتة they
+
+92
+00:07:52,090 --> 00:07:57,530
+are alpha globulin و يصنعوا في ال white blood cell
+
+93
+00:07:57,530 --> 00:08:04,520
+granulesand they are known as R binders وموجودين
+
+94
+00:08:04,520 --> 00:08:08,760
+في عدد هائل من ال blood fluid اللي موجودة في الجسم
+
+95
+00:08:08,760 --> 00:08:14,540
+ووجدوا انه ترانسكوب الأمين واحد و تلاتة مش زي
+
+96
+00:08:14,540 --> 00:08:21,690
+اتنين ما بيوصلوا ال vitamin لأالـ developing cell
+
+97
+00:08:21,690 --> 00:08:27,390
+before twelve days يعني بدهم اتناشر يوم عشان
+
+98
+00:08:27,390 --> 00:08:34,210
+يكسبوهم R binders مرتبطين بالويتامين بقوة ومن هذا
+
+99
+00:08:34,210 --> 00:08:39,270
+المنطلق ال congenital absence لهذه الحوائل الروابط
+
+100
+00:08:39,270 --> 00:08:45,330
+اللي هي ال transporter ما بيعمل يعني has no
+
+101
+00:08:45,330 --> 00:08:47,770
+physiological impairment يعني ما بيعمل
+
+102
+00:08:47,770 --> 00:08:52,800
+megaloplasticوده الصورة هى ال vitamin B12 دخل مع
+
+103
+00:08:52,800 --> 00:08:56,140
+الأكل صار له liberation فى ال stomach فىه فى ال
+
+104
+00:08:56,140 --> 00:08:59,900
+stomach intrinsic factor ارتبط بال vitamin B12
+
+105
+00:08:59,900 --> 00:09:03,720
+وصار فى عندنا B12 intrinsic factor complex اللى
+
+106
+00:09:03,720 --> 00:09:09,040
+هينزل فى الأمعاهو هناك في ال helium ده هو فيه
+
+107
+00:09:09,040 --> 00:09:12,820
+receptor لهذا ال complex فبرتبط في ال receptor و
+
+108
+00:09:12,820 --> 00:09:18,360
+بيصير internalization لل receptor مع ال complex و
+
+109
+00:09:18,360 --> 00:09:25,280
+بيخش على ال portal circulation as طبعا يعني هو ال
+
+110
+00:09:25,280 --> 00:09:30,620
+complex و هناك بيسموه hydrolysis فبيفقمن ال .. من
+
+111
+00:09:30,620 --> 00:09:35,580
+ال .. من ال complex و بيصير free فبيتلقفوا من
+
+112
+00:09:35,580 --> 00:09:39,520
+الحامل و هو transcript الأمين two اللي بياخدوا و
+
+113
+00:09:39,520 --> 00:09:43,940
+بيودّي على وين ايو delivery to the tissue اللي
+
+114
+00:09:43,940 --> 00:09:48,360
+اتفقنا عليها سواء كانت في ال bone marrow اخر في
+
+115
+00:09:48,360 --> 00:09:54,830
+المخازن نفس الصورة تشرح نفس الحكايةهذا ما يتعلق
+
+116
+00:09:54,830 --> 00:10:01,410
+بال واتامين بيتورو الفوليت الفوليت
+
+117
+00:10:01,410 --> 00:10:13,130
+اسد هو ال parent او فوليت و زى ما انتوا شايفى ال
+
+118
+00:10:13,130 --> 00:10:18,230
+structure تبعه مبين و كمان الانسان لايستطيع تصنيعه
+
+119
+00:10:18,230 --> 00:10:24,190
+وبالتالي مصدره الأساسى هو الأكل دورهبلعب دور كبير
+
+120
+00:10:24,190 --> 00:10:29,190
+as a single carbon donor acceptor بيعطي و بياخد
+
+121
+00:10:29,190 --> 00:10:34,970
+ذرة carbon طبعا متمثلة ال methyl group و شوفوا هذه
+
+122
+00:10:34,970 --> 00:10:39,730
+الوظائف الخمسة تبعته مرة واحد synthesis of
+
+123
+00:10:39,730 --> 00:10:46,430
+methionine كيف جالوا بيعطي methyl group من ال M5
+
+124
+00:10:46,430 --> 00:10:47,930
+methyl tetrahydrofolate
+
+125
+00:10:51,290 --> 00:10:57,190
+وبالتالي its form
+
+126
+00:10:57,190 --> 00:11:00,070
+الميثيونين بيتكوّن وطبعا ال vitamin B12 في هذا
+
+127
+00:11:00,070 --> 00:11:04,990
+الحالة بيكون as coenzyme يعني الفولك أسد هو الأساس
+
+128
+00:11:04,990 --> 00:11:09,630
+في عملية تصنيع الميثيونين لكن يحتاج الى ال vitamin
+
+129
+00:11:09,630 --> 00:11:16,430
+B12 as a coenzyme بيسمى purein و puremedine و هذه
+
+130
+00:11:16,430 --> 00:11:21,890
+خطوات مهمة جدافي تصنيع ال DNA ثم conversion of
+
+131
+00:11:21,890 --> 00:11:27,990
+Serine into Glycine واخر واحدة هستدين كتابولزم
+
+132
+00:11:27,990 --> 00:11:36,530
+وهذا هي ال cycles اللي بيتمثل ال metabolic pathway
+
+133
+00:11:36,530 --> 00:11:43,590
+of folic acid في عندنا cycle أساسية هذا هي تبدأ
+
+134
+00:11:43,590 --> 00:11:49,680
+بال N5-methyltidrihydrofolateتتحول إلى
+
+135
+00:11:49,680 --> 00:11:56,040
+Tetrahydrofolate طبعا هذا في وجود vitamin B12 في
+
+136
+00:11:56,040 --> 00:11:59,720
+ال homocysteine بتتحول لميثيونين ثم
+
+137
+00:11:59,720 --> 00:12:04,040
+Tetrahydrofolate تتحول
+
+138
+00:12:04,040 --> 00:12:09,500
+إلى N5 N10 مثيرين Tetrahydrofolate وأيضا في هذا
+
+139
+00:12:09,500 --> 00:12:13,240
+الخطوة ده هو تحقق اللي هو تحول السيرين إلى Glycine
+
+140
+00:12:13,240 --> 00:12:20,880
+ثم بعد ذلك ل N5 N10بيتحول ل Dihydrofolate على جانب
+
+141
+00:12:20,880 --> 00:12:27,220
+هذا التفاعل بيتم تصنيع DUNB إلى DTMB من الـ DUNB و
+
+142
+00:12:27,220 --> 00:12:31,680
+طبعا هذه خطوة مهمة في تصنيع الـ DNA والعرنين اللي
+
+143
+00:12:31,680 --> 00:12:36,340
+بعد هيك ال Dihydrofolate بيتحول ل Tetrahydrofolate
+
+144
+00:12:36,340 --> 00:12:40,360
+مرة تانية بوسط ال Dihydrofolate Reductase Enzyme
+
+145
+00:12:40,360 --> 00:12:45,220
+في ال cycle التحتنية هذه احنا هذا هناتحول
+
+146
+00:12:45,220 --> 00:12:49,940
+الهوموشستين لميثيونين تحول السيرين إلى جليسين ثم
+
+147
+00:12:49,940 --> 00:12:57,060
+في DNA ماشي وRNA synthesis هي أربع وظائف ولو جينا
+
+148
+00:12:57,060 --> 00:13:01,600
+للساكل الفجنية دي هوموشستين بتحول لميثيونين و
+
+149
+00:13:01,600 --> 00:13:07,200
+الادنوزيل ميثيونين بيتحول بعد هي ل S-adenosyl
+
+150
+00:13:07,200 --> 00:13:10,720
+-homocystein اللي بعد هي بتتحول لهموشستين مرة
+
+151
+00:13:10,720 --> 00:13:15,810
+تانيةتحول الهوموسستين الى ميثيونين تحول
+
+152
+00:13:15,810 --> 00:13:19,810
+الهوموسستين الى ميثيونين تحول الهوموسستين الى
+
+153
+00:13:19,810 --> 00:13:25,570
+ميثيونين تحول الهوموسستين الى ميثيونين تحول
+
+154
+00:13:25,570 --> 00:13:27,710
+الهوموسستين الى ميثيونين تحول الهوموسستين الى
+
+155
+00:13:27,710 --> 00:13:28,250
+ميثيونين تحول الهوموسستين الى ميثيونين تحول
+
+156
+00:13:28,250 --> 00:13:31,090
+الهوموسستين الى ميثيونين تحول الهوموسستين الى
+
+157
+00:13:31,090 --> 00:13:31,090
+ميثيونين تحول الهوموسستين الى ميثيونين تحول
+
+158
+00:13:31,090 --> 00:13:31,330
+الهوموسستين الى ميثيونين تحول الهوموسستين الى
+
+159
+00:13:31,330 --> 00:13:36,010
+ميثيونين تحول الهوموسستين الى ميثيونين تحول
+
+160
+00:13:41,440 --> 00:13:45,900
+daily our requirement of aphric acid and storage
+
+161
+00:13:45,900 --> 00:13:51,160
+دلوقت لنا اليوم فيه 100 مايكرو في دراعهم طبعا
+
+162
+00:13:51,160 --> 00:13:54,880
+mainly نفقدهم
+
+163
+00:13:56,850 --> 00:14:01,630
+سوى بيه؟ تاكر اليوم؟ يا اللي جيتها نشوف فيه كتير
+
+164
+00:14:01,630 --> 00:14:08,250
+فيه سبعمائة daily احنا بنفقد daily في ال meet
+
+165
+00:14:08,250 --> 00:14:11,750
+microgram من ال folic acid غالبا بنفقدها في
+
+166
+00:14:11,750 --> 00:14:16,770
+الفيسيا والارنان والسويد ماشيووجدوا ان الفيسر في
+
+167
+00:14:16,770 --> 00:14:20,110
+كميات كبيرة من ال vitamin B12 و ال folic acid لكن
+
+168
+00:14:20,110 --> 00:14:23,650
+مش من الأكل هذه جاية من ال normal microbial flora
+
+169
+00:14:23,650 --> 00:14:27,650
+activity اللي موجودة في ال .. في ال ايش؟ في ال ..
+
+170
+00:14:27,650 --> 00:14:34,330
+ال stool وبالتالي لا يستفد منها لأنها تصنع بعد
+
+171
+00:14:34,330 --> 00:14:36,850
+مواقع انتصاص ال folic acid
+
+172
+00:14:41,220 --> 00:14:50,520
+لكن عشان نحافظ على مخازن الفولك أسد مليانة لازم ال
+
+173
+00:14:50,520 --> 00:14:56,440
+normal other requirement تكون في حدود ما يفقد وهي
+
+174
+00:14:56,440 --> 00:15:02,060
+ال 100 ميكرو جرام ماشي تخزن هذه الكمية mainly في
+
+175
+00:15:02,060 --> 00:15:06,210
+ال liverو الفولك أسد بشكل عام موجود في ال leafy
+
+176
+00:15:06,210 --> 00:15:11,210
+vegetable اللي هو ال grains في ال yeast but it's
+
+177
+00:15:11,210 --> 00:15:15,870
+الفولك أسد بحيث ذاته is extremely sensitive to
+
+178
+00:15:15,870 --> 00:15:22,510
+heat عشان هيك عملية الطبخ بالطويلة بتفقد كمية
+
+179
+00:15:22,510 --> 00:15:29,190
+كبيرة منهو ببساطة الميت مايكرو جرام اللى بنحتاجها
+
+180
+00:15:29,190 --> 00:15:33,250
+يومى بناخدها من الأكل اللى فى كمية كبيرة بتوصل لـ
+
+181
+00:15:33,250 --> 00:15:37,850
+700 مايكرو جراملكن للأسف الشديد زى ما قلنا لكوا مع
+
+182
+00:15:37,850 --> 00:15:44,270
+الطبخ برلود cooking بيأدى لفقدان كميات كبيرة من
+
+183
+00:15:44,270 --> 00:15:53,770
+الفليك أسد و مهما نفقد بيظل كمية تقريبا بتساوي
+
+184
+00:15:53,770 --> 00:16:03,230
+ما نحتاجه يوميا مخازن الفليك أسد فى الجسم تحتوي
+
+185
+00:16:03,230 --> 00:16:03,890
+على عشرة
+
+186
+00:16:09,630 --> 00:16:15,180
+لكن لو كان الفريك اسد فهو ممكن يخزن في الفريكبهذه
+
+187
+00:16:15,180 --> 00:16:19,660
+الكمية المخزون الفوليك أسد بهذه الكمية لا يكفينا
+
+188
+00:16:19,660 --> 00:16:27,380
+إلا إلى تلاتة إلى أربع شهور بعد توقف امتصاص أو أخذ
+
+189
+00:16:27,380 --> 00:16:32,140
+الفوليك أسد وهذه فترة حرجة جدا وخصوصا في
+
+190
+00:16:32,140 --> 00:16:37,100
+البرجنانسي لأن البرجنانسي فترته تسعة شهور واحنا
+
+191
+00:16:37,100 --> 00:16:44,390
+مخازينا لا تكفينا إلا إلى تلت شهور كيف امتصيعني هو
+
+192
+00:16:44,390 --> 00:16:49,630
+يمتص في الأعضاء الـ Digital وغالبا بيتحول الفولي
+
+193
+00:16:49,630 --> 00:16:52,910
+عشان يمتص بيتحول ال polyglutamate folic acid او
+
+194
+00:16:52,910 --> 00:17:00,130
+folate الى monoglutamate قبل الامتصاص و بعد ما
+
+195
+00:17:00,130 --> 00:17:03,730
+بيخش as monoglutamate بيتحول لأنفع مثال
+
+196
+00:17:03,730 --> 00:17:07,290
+tetrahydrofolate اللي بعد هيك بيصلها releasing في
+
+197
+00:17:07,290 --> 00:17:13,490
+ال portal circulation والـ folate usually
+
+198
+00:17:13,490 --> 00:17:18,990
+circulates freely أو بعض المرات بيكون مرتبط مع
+
+199
+00:17:18,990 --> 00:17:27,950
+plasma protein يعني الناقل لل folate still is
+
+200
+00:17:27,950 --> 00:17:35,330
+unknown بيقول انه عادة بيcirculate freely في الدم
+
+201
+00:17:35,330 --> 00:17:40,910
+او بيكون مرتبط ببعض البروتينات وفي بعض الدلائل
+
+202
+00:17:41,440 --> 00:17:47,540
+العلمية اللى بتقول انه there is transport protein
+
+203
+00:17:47,540 --> 00:17:52,780
+for folic acid وإنه في غياب ال folic acid this
+
+204
+00:17:52,780 --> 00:17:59,720
+protein is increased لإنه لم يُشتغل لإنه لم يُشتغل
+
+205
+00:17:59,720 --> 00:18:03,780
+أبي مقدّم سريعًا folic acid و vitamin B12 واخدنا
+
+206
+00:18:03,780 --> 00:18:08,160
+ال chemistry of both ونتطبق الآن إلى ال
+
+207
+00:18:08,160 --> 00:18:13,340
+megaloplastic anemiaاللي هي غالبا ناتجة عن
+
+208
+00:18:13,340 --> 00:18:19,080
+deficiency of both نجال ال plastic anemia تعريفا
+
+209
+00:18:19,080 --> 00:18:26,020
+هي عبارة عن pan hypoplastic disorder شو يعني pan
+
+210
+00:18:26,020 --> 00:18:32,380
+hypoplastic disorder pan معناتها كل وhypo معناتها
+
+211
+00:18:32,380 --> 00:18:40,310
+قلة و plastic تصنيع يعني صار فيه قلةفي تصنيع كل
+
+212
+00:18:40,310 --> 00:18:47,250
+الخلايا في البودمارون بيسمو المصطلح panhypoplastic
+
+213
+00:18:47,250 --> 00:18:51,150
+disorder and it's usually characterized by
+
+214
+00:18:51,150 --> 00:18:54,150
+retardation of DNA synthesis طبيعي جدا مازال مافيش
+
+215
+00:18:54,150 --> 00:18:57,250
+vitamin بتول مش راح يستثمر اللي هو ال DNA و
+
+216
+00:18:57,250 --> 00:19:01,230
+الأعرانية و ال folic acid طبعا وبالتالي ما بيصير
+
+217
+00:19:01,230 --> 00:19:09,120
+فيه تطور مش راح يتصنع ال DNAوبالتالي مافي تطور
+
+218
+00:19:09,120 --> 00:19:13,700
+للنكليز وبيصير فيه retardation of DNA synthesis
+
+219
+00:19:13,700 --> 00:19:18,440
+لكن بالمناسبة ال RNA بتتم تصنيعه في ال cytoplasm
+
+220
+00:19:18,440 --> 00:19:22,780
+وبالتالي ال cytoplasm بيستمر في التطور فبيصير فيه
+
+221
+00:19:22,780 --> 00:19:27,640
+نوع من ال asynchronous عدم التوافق ما بين نمو
+
+222
+00:19:27,640 --> 00:19:31,540
+النواء وما بين نمو ال cytoplasm
+
+223
+00:19:34,570 --> 00:19:40,490
+بيسموا هذه الحالة Asynchronism او Asynchronous
+
+224
+00:19:40,490 --> 00:19:45,550
+status ما بين Nuclear and cytoplasmic maturation
+
+225
+00:19:45,550 --> 00:19:51,270
+وطبعا هذه هي المسئولة عن ال Distinct morphological
+
+226
+00:19:51,270 --> 00:19:54,170
+and biochemical feature تبعت الميجالو
+
+227
+00:19:54,170 --> 00:20:00,170
+بلاستيكالينيا اسبابها قلنا اما vitamin B12 or
+
+228
+00:20:00,170 --> 00:20:04,270
+folic acid deficiencyor sometimes both الاتنين
+
+229
+00:20:04,270 --> 00:20:11,250
+بيكونوا معاهم ويوجدوا انه في اسباب اخرى زى ما
+
+230
+00:20:11,250 --> 00:20:15,250
+قلنالكوا غير ال vitamin b12 و ال volfolic acid ان
+
+231
+00:20:15,250 --> 00:20:21,830
+شاء الله بنتطرق اليهاطبعا نشوف أولا أسباب نقص ال
+
+232
+00:20:21,830 --> 00:20:26,410
+vitamin B12 في البصمة نقول فيها أنها أربع أسباب
+
+233
+00:20:26,410 --> 00:20:36,310
+أساسية وهي ببساطة زي أي نوتريشنال component بأسباب
+
+234
+00:20:36,310 --> 00:20:42,630
+نقصه بيندرج تحت القاتل نمرا واحد أنه بيكون الأكل
+
+235
+00:20:42,630 --> 00:20:48,980
+مش فيه vitamin نمرا اتنينبيكون الأكل محتوي على ال
+
+236
+00:20:48,980 --> 00:20:52,320
+vitamin لكن فيه intestinal مالة absorption ماعب
+
+237
+00:20:52,320 --> 00:20:57,820
+نمطسه نمرة تلاتة أخدنا ال vitamin من الأكل و
+
+238
+00:20:57,820 --> 00:21:04,400
+نمطسناه لكن في زيادة في الطلب عليه بكميات
+
+239
+00:21:04,400 --> 00:21:12,750
+أكبر من ما يمطسمرة اربعة خدنا ال vitamin وانتصنا
+
+240
+00:21:12,750 --> 00:21:20,990
+ودخل الجسم بكميات مطلوبة لكن الجسم فشل في استغلاله
+
+241
+00:21:20,990 --> 00:21:26,350
+وفي استهلاكه لل vitamin يعني مافيش استغلال جيد لل
+
+242
+00:21:26,350 --> 00:21:30,030
+vitaminونشوف هذه الأسباب نمرة واحد inadequate
+
+243
+00:21:30,030 --> 00:21:33,390
+dietary intake واتفقنا على انه it's uncommon cause
+
+244
+00:21:33,390 --> 00:21:37,310
+للأسباب التالية نمرة واحد قولنا ان الأكل موجود
+
+245
+00:21:37,310 --> 00:21:41,870
+بكميات كبيرة في أكلنا الشرقي ونمرة اتنين it's
+
+246
+00:21:41,870 --> 00:21:46,050
+relatively heat stable ما بنفقده أثناء ال cooking
+
+247
+00:21:46,050 --> 00:21:50,550
+نمرة تلاتة مخزونة بيكفينا إلى سنوات at least for
+
+248
+00:21:50,550 --> 00:21:56,700
+three yearsماشى بعد ما نوقف اخد اللى هو ال vitamin
+
+249
+00:21:56,700 --> 00:22:02,240
+تماما ما ال absorption and this is common وطبعا
+
+250
+00:22:02,240 --> 00:22:07,540
+على عكس ذات لسبب الاولان قالوا اسبابها ممكن تكون
+
+251
+00:22:07,540 --> 00:22:12,060
+lack of intrinsic factor مفيش مفيش امتصاص صح طبعا
+
+252
+00:22:12,060 --> 00:22:15,200
+اذا مافيش امتصاص قالوا اسباب كالقاتى lack of
+
+253
+00:22:15,200 --> 00:22:20,300
+intrinsic factor which is importantمافيش intrinsic
+
+254
+00:22:20,300 --> 00:22:24,240
+factor يبقى مافيش تكوين للكمplex من أصله
+
+255
+00:22:24,240 --> 00:22:29,500
+gastrointestinal disease في حالة مرضية في الجهاز
+
+256
+00:22:29,500 --> 00:22:34,480
+الحضني و ال drug induced mal absorption دخل علاج
+
+257
+00:22:34,480 --> 00:22:38,960
+عمل blocking لل absorption of vitamin B12 و نبدأ
+
+258
+00:22:38,960 --> 00:22:42,520
+في أول هذه الأسباب و هي lack of intrinsic factor و
+
+259
+00:22:42,520 --> 00:22:48,550
+بعمل قانينةمميزة سموها pernicious anemia وهي
+
+260
+00:22:48,550 --> 00:22:52,550
+ميجانو بلاستيك ميجانو
+
+261
+00:22:52,550 --> 00:22:56,590
+بلاستيك انيميا لكن الانيميا اللى ناجي عن نقص ال
+
+262
+00:22:56,590 --> 00:23:02,390
+intrinsic factor بسموها pernicious انيميا and it's
+
+263
+00:23:02,390 --> 00:23:06,070
+by far the most common cause of B12 deficiency
+
+264
+00:23:06,070 --> 00:23:12,150
+ووجدوها موجودة بنسبة عالية بتوصل ل 2% في الناس
+
+265
+00:23:12,150 --> 00:23:12,870
+الاختيارية
+
+266
+00:23:15,260 --> 00:23:18,480
+وغالبا associated with blood group A ناس اللي
+
+267
+00:23:18,480 --> 00:23:23,780
+فصيلت دمهم A وموجودة في ال women أكتر من إيش من ال
+
+268
+00:23:23,780 --> 00:23:29,160
+men شوهت بيرنيشا ثانيميا قالوا غالبا بيرنيشا
+
+269
+00:23:29,160 --> 00:23:32,380
+ثانيميا اللي بيصير فيها انه بيصير في intestinal
+
+270
+00:23:32,380 --> 00:23:36,440
+malabsorption طبعاش السبب؟ قالوا في gastric
+
+271
+00:23:36,440 --> 00:23:42,700
+atrophy للميوكوزل البرايتل سيل اللي بتصنع ال
+
+272
+00:23:42,700 --> 00:23:48,810
+intrinsic factor في ال stomachو حديثا بوضعوا بعض
+
+273
+00:23:48,810 --> 00:23:52,030
+النظريات بتقول انه في علاقة ما بين ال autoimmune
+
+274
+00:23:52,030 --> 00:23:59,790
+disease و ال pernicia ثانية و
+
+275
+00:23:59,790 --> 00:24:05,700
+أثبتوا هذا الكلامبعد ما اعطوا كورتيكوستيرويد
+
+276
+00:24:05,700 --> 00:24:11,320
+ثيرابي والكورتيكوستيرويد ثيرابي بتعمل suppression
+
+277
+00:24:11,320 --> 00:24:15,080
+لل immune response ففي حالة ال autoimmune لو عملنا
+
+278
+00:24:15,080 --> 00:24:20,700
+suppression لل immune response احنا بنحسن حالة
+
+279
+00:24:20,700 --> 00:24:24,720
+المريض وفي هذه الحالة تحسن مريض ال pernicious
+
+280
+00:24:24,720 --> 00:24:26,980
+anemia يوم ما اعطينا كورتازون
+
+281
+00:24:30,300 --> 00:24:34,740
+هناك اقتراح ان هناك علاقة بين الهيليوكوباكتر
+
+282
+00:24:34,740 --> 00:24:40,940
+ايلوري و البرنيشا ثانيميا لكن كل الأبحاث التي تمت
+
+283
+00:24:40,940 --> 00:24:48,080
+نفت هذا الاختراح في البرنيشا ثانيميا ما يميزها ان
+
+284
+00:24:48,080 --> 00:24:54,840
+90% من المرضى عندهم cytotoxic IgG واسمه cytotoxic
+
+285
+00:24:54,840 --> 00:24:59,710
+يعني انه toxic للخلايا اللي برتبط فيهاطيب موجه
+
+286
+00:24:59,710 --> 00:25:04,670
+لمين؟ قالوا موجه لل gastric parietal cell او لل
+
+287
+00:25:04,670 --> 00:25:09,030
+intrinsic factor اللي بتصنع ال parietal cell وين؟
+
+288
+00:25:09,030 --> 00:25:16,010
+في ال serum يبقى 90% من المرضى عندهم IGG which can
+
+289
+00:25:16,010 --> 00:25:20,990
+block either the parietal cell or the intrinsic
+
+290
+00:25:20,990 --> 00:25:26,890
+factor اللي بيصنع ال parietal cellكمان وجدوا ان في
+
+291
+00:25:26,890 --> 00:25:31,730
+75% من المرضى ان الانتيباضي هذا موجود في ال
+
+292
+00:25:31,730 --> 00:25:34,910
+gastric juice مش في ال serum اه في ال gastric
+
+293
+00:25:34,910 --> 00:25:38,890
+juice وكمان
+
+294
+00:25:38,890 --> 00:25:46,390
+وجدوا انه في polyclonal IgG و IgA in
+
+295
+00:25:46,390 --> 00:25:51,830
+both serum and gastric juice لكن بنسبة ايش 50% من
+
+296
+00:25:51,830 --> 00:25:56,420
+المرضىيبقى 90% من المرضى عندهم Antibody في الـ
+
+297
+00:25:56,420 --> 00:26:00,040
+Serum و 75% من المرضى عندهم Antibody في الـ
+
+298
+00:26:00,040 --> 00:26:04,680
+Gastric Juice و 50% من المرضى عندهم both IgG و IgA
+
+299
+00:26:04,680 --> 00:26:10,620
+in both Serum و Gastric Juice كيف
+
+300
+00:26:10,620 --> 00:26:15,880
+يشتغل هذا الـ Antibody؟ قالوا إما بمنع ارتباط الـ
+
+301
+00:26:15,880 --> 00:26:20,060
+Vitamin B12 بالـ Intrinsic Factor و في هذه الحالة
+
+302
+00:26:20,060 --> 00:26:25,830
+بسموه Type I Antibodyوإما بعمل انهيبشين لل
+
+303
+00:26:25,830 --> 00:26:32,450
+absorption of complex وفي
+
+304
+00:26:32,450 --> 00:26:35,290
+هذه الحالة بيسموه type 2 antibody
+
+305
+00:26:39,730 --> 00:26:43,950
+بيثبت انه لها علاقة بال ايش بال autoimmune disease
+
+306
+00:26:43,950 --> 00:26:48,050
+وجدوها في كثير من الحلات ال autoimmune disease زي
+
+307
+00:26:48,050 --> 00:26:51,430
+ال autoimmune thyroid disease و ال rheumatoid
+
+308
+00:26:51,430 --> 00:26:56,950
+arthritis و ال gastric carcinoma وبالتالي في علاقة
+
+309
+00:26:56,950 --> 00:27:02,270
+ما بين ال autoimmune و ال هذه و ال pernicious
+
+310
+00:27:02,270 --> 00:27:07,990
+anemia و وجدوا فيه نوع نادر النوع النادر هذا غالبا
+
+311
+00:27:08,640 --> 00:27:11,360
+associated with congenital deficiency بيكون فيه
+
+312
+00:27:11,360 --> 00:27:14,540
+غياب congenitally لل factor اللي هو ال intrinsic
+
+313
+00:27:14,540 --> 00:27:21,360
+factor او انه يصنع لكنه يصنع dysfunctional يعني مش
+
+314
+00:27:21,360 --> 00:27:26,700
+شغال فكده يرتبط وهذه ال pernicious يعني انها في
+
+315
+00:27:26,700 --> 00:27:32,320
+الوضع الطبيعي ده هي اي في ال membrane of gastric
+
+316
+00:27:32,320 --> 00:27:37,340
+stomach ده هي وهي ال parietal cell كلها موجودة
+
+317
+00:27:37,820 --> 00:27:41,180
+وطبعا إذا كانها موجودة بتصنع acid وهو ال
+
+318
+00:27:41,180 --> 00:27:46,960
+hydrochloric acid وبتصنع ال intrinsic factor ماشي
+
+319
+00:27:46,960 --> 00:27:50,720
+لكن في الparietal cell مافيش parietal cell صار
+
+320
+00:27:50,720 --> 00:27:56,500
+atrophy لل parietal cell وبالتالي صار في a
+
+321
+00:27:56,500 --> 00:28:00,260
+-chlorohydra يعني مافي تصنيع لل hydrochloric acid
+
+322
+00:28:00,260 --> 00:28:08,290
+ومافي تصنيع لل intrinsic factorطيب كيف انا اشخص ال
+
+323
+00:28:08,290 --> 00:28:12,710
+بيرنيشه سالمه جاله ان اشخصها بفحص بيسموه shelling
+
+324
+00:28:12,710 --> 00:28:19,170
+test و shelling test يا بنات و يا شباب هو عبارة عن
+
+325
+00:28:19,170 --> 00:28:28,490
+فحص بتم كالقاتي بنجيب احنا شوية كبدة ماشي و بنحط
+
+326
+00:28:28,490 --> 00:28:34,390
+عليها B12 لكنه radio labeled و بنطعمه للمريض
+
+327
+00:28:35,900 --> 00:28:40,720
+وبنتتبع ال vitamin B12 لان هو radio-elabled ونشوفه
+
+328
+00:28:40,720 --> 00:28:45,740
+طلع
+
+329
+00:28:45,740 --> 00:28:50,040
+في ال urine و ال feces ولا ما طلع طبعا في هذه
+
+330
+00:28:50,040 --> 00:28:56,560
+الحالة هنلاقي الكمية اللي حطناها في شوية
+
+331
+00:28:56,560 --> 00:29:02,960
+الكده اللي طعمناها للمريض هتطلع زينا هي وين في ال
+
+332
+00:29:02,960 --> 00:29:07,160
+fecesوطبعا احنا عاملين Radio Labeling يعني اللي
+
+333
+00:29:07,160 --> 00:29:13,000
+بندور عليه مبين معروف معلم هذا
+
+334
+00:29:13,000 --> 00:29:17,000
+الكلام بيصير في حالة البرنيشة ثانية لو كررنا
+
+335
+00:29:17,000 --> 00:29:25,660
+العملية و في المرة التانية حطينا ال P12 as a
+
+336
+00:29:25,660 --> 00:29:30,560
+complex with intrinsic factor ال radio label P12
+
+337
+00:29:30,560 --> 00:29:35,450
+حطناهمرتبط بال Intrinsic factor وطعمناها للمريض و
+
+338
+00:29:35,450 --> 00:29:42,030
+تتبعنا ال B12 حتي يحصل فيه امتصاص و السبب و ذلك من
+
+339
+00:29:42,030 --> 00:29:51,130
+خلال عدم خروج ال B12 في ال folic acid و في ال
+
+340
+00:29:51,130 --> 00:29:57,250
+urine و ال feces ايه ده ال shelling test هو عبارة
+
+341
+00:29:57,250 --> 00:30:04,660
+عن فحص بتتبع من خلالهفشل الامتصاص في ال step
+
+342
+00:30:04,660 --> 00:30:10,720
+الأولانية ثم نجاح الامتصاص في ال step التانية في
+
+343
+00:30:10,720 --> 00:30:15,680
+وجود ال intrinsic factor وبالتالي يكون السبب غياب
+
+344
+00:30:15,680 --> 00:30:19,960
+ال intrinsic factor treatment of pernicious anemia
+
+345
+00:30:19,960 --> 00:30:26,400
+قالوا اليوم بيعطوا ال B12 azambul injectionبتركيز
+
+346
+00:30:26,400 --> 00:30:31,380
+الف ميكرو جرام weekly يوم انشخص مريض عنده
+
+347
+00:30:31,380 --> 00:30:35,780
+megaloplastic anemia نتيجة ال bitwell deficiency
+
+348
+00:30:35,780 --> 00:30:41,020
+بيروحوا على معتين اللي هو one ampoule بتركيز الف
+
+349
+00:30:41,020 --> 00:30:45,920
+ميكرو جرام of bitwell weekly لغاية ما تنطلي مخازن
+
+350
+00:30:45,920 --> 00:30:51,900
+المريض ثم بستمر في اعطاء هذه الإبرة لكن بدل كل
+
+351
+00:30:51,900 --> 00:30:58,880
+أسبوع ندهله كل شهرحاولوا طبعا لإنه انك تعطي قبرت
+
+352
+00:30:58,880 --> 00:31:05,140
+اسبوعي لاسبوعي او monthly يعني عملية مزعجة فحاولوا
+
+353
+00:31:05,140 --> 00:31:12,020
+يصنعوا oral و intranasal B12 لكنهم لغاية الآن
+
+354
+00:31:12,020 --> 00:31:22,160
+فشلوا في تصنيع هذا المكوّن ماشي و خلينا نجا فهام
+
+355
+00:31:22,860 --> 00:31:27,960
+عشان ايش؟ عشان نزغر ال ..
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/Ed2r3iV6WnM_raw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/Ed2r3iV6WnM_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a45e121be50bf080191b9acccdfceaff70769bb8
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/Ed2r3iV6WnM_raw.srt
@@ -0,0 +1,1416 @@
+1
+00:00:11,260 --> 00:00:14,120
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:14,120 --> 00:00:18,580
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+3
+00:00:18,580 --> 00:00:23,360
+آله وصحابه وسلم اليوم ان شاء الله موضوعنا عن مقدمة
+
+4
+00:00:23,360 --> 00:00:29,200
+في علم التجويض مقدمات حول هذه المادةبداية نتعرف
+
+5
+00:00:29,200 --> 00:00:35,240
+على تعريف التجويد التجويد من حيث اللغة يا أخوات هو
+
+6
+00:00:35,240 --> 00:00:42,140
+من التحسين ومنه جيد جوّدت الشيء بمعنى حسنته يقال
+
+7
+00:00:42,140 --> 00:00:47,600
+جوّد فلان الشيء بمعنى حسنه والتجويد في الإصطلاح هو
+
+8
+00:00:47,600 --> 00:00:53,280
+علم يبحث في ألفاظ القرآن الكريممن حيث إخراجه كل
+
+9
+00:00:53,280 --> 00:00:58,500
+حرف من مخرجه وإعطاه حقه ومستحقه من الصفات، إذا
+
+10
+00:00:58,500 --> 00:01:04,510
+تعريف علم التجويضعلم يبحث في ألفاظ القرآن الكريم
+
+11
+00:01:04,510 --> 00:01:09,450
+من حيث إخراج كل حرف من مخرجه يعني هذا الحرف من أين
+
+12
+00:01:09,450 --> 00:01:14,850
+يخرج وما هي صفاته وكيف نتكلم ونلفظ هذا الحرف إذا
+
+13
+00:01:14,850 --> 00:01:18,990
+تعريف المتجويد هو علم يبحث في ألفاظ القرآن الكريم
+
+14
+00:01:18,990 --> 00:01:24,250
+من حيث إخراج كل حرف من مخرجه وإعطائه حقه ومستحقه
+
+15
+00:01:24,250 --> 00:01:31,830
+من الصفاتفي عندنا حقه ومستحقه ما المقصود بقولنا حق
+
+16
+00:01:31,830 --> 00:01:36,710
+الحرف؟ وما المقصود كذلك بقولنا مستحق الحرف؟ إذا حق
+
+17
+00:01:36,710 --> 00:01:43,460
+الحرف هو ماذا؟فك عن الحرف كالجهر والشدة والقلقلة
+
+18
+00:01:43,460 --> 00:01:46,980
+والغنى إذا حق الحرف يا أخوان هو الصفات الملازمة
+
+19
+00:01:46,980 --> 00:01:51,700
+للحرف التي لا تنفك عنه بأي حالة من الأحوال كالشدث
+
+20
+00:01:51,700 --> 00:01:56,900
+والجهر والاستعلاء والقلقلة والغنى يعني صفات ملازمة
+
+21
+00:01:56,900 --> 00:02:03,040
+للحرف مثل مثلا حرف القاف ملازمة صفة القلقلة والشدة
+
+22
+00:02:03,040 --> 00:02:07,940
+والجهر والاستعلاء هذه الصفات لو جاء الحرف لوحده
+
+23
+00:02:09,090 --> 00:02:14,170
+مثلا صفة القلقلة لو جاء الحرف لوحدهم نقول أقق فيها
+
+24
+00:02:14,170 --> 00:02:19,270
+قلقلة و شدة و جهرة لو جئنا في وسط الكلمة نقول
+
+25
+00:02:19,270 --> 00:02:25,870
+مقتدراها مقق فيها قلقلة صغيرةلو جاء في آخر الكلمة
+
+26
+00:02:25,870 --> 00:02:31,930
+الحق إذا فيه قلقلة، إذا مستحق .. حق الحرف هو إعطاء
+
+27
+00:02:31,930 --> 00:02:37,390
+كل حرف أو الصفات المنازمة لهذا الحرف التي لا يمكن
+
+28
+00:02:37,390 --> 00:02:41,130
+أن تنفك عنه بأي حالة من الأحوال سواء كان في ..
+
+29
+00:02:41,130 --> 00:02:45,990
+لوحده ولا في منتصف الكلمة ولا في آخر الكلمة أما
+
+30
+00:02:45,990 --> 00:02:50,390
+بالنسبة لمستحق الحرف هو .. فضل أخت في الصفات
+
+31
+00:02:50,390 --> 00:02:54,010
+العارضة التي يتصف بها الحرف أحيانا في حالة متفرطة
+
+32
+00:02:55,540 --> 00:03:00,600
+مستحق الحرف هو الصفات العارضة التي تلازم الحرف
+
+33
+00:03:00,600 --> 00:03:08,040
+أحيانا و تفارقه أحيان أخرى مثال ذلك حرف الرا أحيان
+
+34
+00:03:08,040 --> 00:03:15,660
+نفخمه و أحيان نرققه مثلا كلمة رائد حرف الرا هنا هل
+
+35
+00:03:15,660 --> 00:03:24,610
+هو مفخم ولا مرقق؟ رائد رؤيا رأىكويس؟ إذا هنا حرف
+
+36
+00:03:24,610 --> 00:03:29,770
+الر مفخم طبعا لأنه مفخم بسبب حالات إذا كان مفتوح،
+
+37
+00:03:29,770 --> 00:03:35,250
+مضموم، حنافض إن شاء الله أو أحيانا يرقق مثل ريح،
+
+38
+00:03:35,250 --> 00:03:41,700
+بريح، نجد أن حرف الر مرقق بريحلذلك حرف الرا أحيانا
+
+39
+00:03:41,700 --> 00:03:46,800
+يفخم و أحيانا يرقق بحالات معينة لو كان قبله فتحة
+
+40
+00:03:46,800 --> 00:03:51,640
+أو جاء مفتوح أو مضموم أو بعده ألف نفخمه كذلك
+
+41
+00:03:51,640 --> 00:03:58,640
+بالنسبة للرا لو كان مكسور أو بعد حرفيا نرقق و هكذا
+
+42
+00:03:58,640 --> 00:04:04,760
+كذلك في عندنا حرف الألف الألف أحيانا يفخم و أحيانا
+
+43
+00:04:04,760 --> 00:04:09,100
+يرقق أحيانا نقول آه و لضاه
+
+44
+00:04:11,890 --> 00:04:18,110
+فخمنا الألف لماذا فقم الألف؟ لأن ما قبله حرف مفخم
+
+45
+00:04:18,110 --> 00:04:23,710
+من حروف الاستعلاق مثلا الطارق طارق ماقولناش تارق
+
+46
+00:04:23,710 --> 00:04:28,310
+لأ الطا من فخم الألف إذا الألف يا أخوات مفخمة
+
+47
+00:04:28,310 --> 00:04:32,250
+لأنها جاءت بعد حرف مفخم وهي تتبع ما قبلها من حيث
+
+48
+00:04:32,250 --> 00:04:38,650
+التفهيم والترقيمو أحياناً يُرقق مثل النار ماقولناش
+
+49
+00:04:38,650 --> 00:04:45,990
+النار النار رققنا حرف الألف لأنه ما قبله مرقق أو
+
+50
+00:04:45,990 --> 00:04:54,320
+مثل سامر تامر ناهضولا نقول طامر .. صامر .. لأ ..
+
+51
+00:04:54,320 --> 00:04:58,520
+لا تفخم الألف إذا الألف يا أخوات أحيانا تفخم و
+
+52
+00:04:58,520 --> 00:05:03,480
+أحيانا طراقة فصفة التفخيم و الترقيق هي صفة يعني
+
+53
+00:05:03,480 --> 00:05:08,440
+عارضة تلازم الحرف في حالات و تفارقه في حالات خاصة
+
+54
+00:05:08,440 --> 00:05:12,360
+هذه الحروف الألف و اللام في لفظ الجلالة و الرام
+
+55
+00:05:12,360 --> 00:05:17,900
+كذلك اللام في لفظ الجلالة أحيانا نقول اللهو أحيانا
+
+56
+00:05:17,900 --> 00:05:22,660
+نقول الله .. مات نقول الله .. يعني هذا اللام في
+
+57
+00:05:22,660 --> 00:05:29,460
+لفظ الجلالة في قولنا الله مفخمة .. إن الله .. إن
+
+58
+00:05:29,460 --> 00:05:36,740
+الله .. رسول الله فخمن اللام .. لكن بسم اللهالحمد
+
+59
+00:05:36,740 --> 00:05:42,720
+لله رققنا اللام لأن ما قبلها مكسور، ترقق أو إذا
+
+60
+00:05:42,720 --> 00:05:47,120
+كان ما قبلها مفتوح أو مضموم، تفخم فاللام في لفظ
+
+61
+00:05:47,120 --> 00:05:50,720
+الجلالة تفخم في حالات و ترقق في حالات، إذا هذه
+
+62
+00:05:50,720 --> 00:05:55,440
+الصفة صفة عارضة، تلازم الحر في حالات و تفارقه في
+
+63
+00:05:55,440 --> 00:06:02,160
+حالات أخرى ننتقل إلى أقسام التجويض طبعا في عندنا
+
+64
+00:06:02,160 --> 00:06:06,930
+لأقسام التجويض كام قسم الأخوات؟عنا قسمين تجويض
+
+65
+00:06:06,930 --> 00:06:12,590
+علمى أو تجويض نظري و تجويض تطبيقى عاملى أما
+
+66
+00:06:12,590 --> 00:06:16,510
+بالنسبة للتجويض العلمى فهو التجويض اللى ندرسه نحن
+
+67
+00:06:16,510 --> 00:06:21,570
+يعنى حسب العلم و التجويض العلمى هو معرفة قواعد و
+
+68
+00:06:21,570 --> 00:06:25,570
+أحكام علم التجويض اللى موجودة فى كتب التجويض نحن
+
+69
+00:06:25,570 --> 00:06:30,010
+عندنا كتاب مقرر علينا و هو هذا الكتاب اسمه المغني
+
+70
+00:06:30,010 --> 00:06:35,270
+فى علم التجويض للدكتور عبد الرحمن الجملندرسه وهذا
+
+71
+00:06:35,270 --> 00:06:39,710
+المقرر علينا وهذا ما يسمى بالتجويض النظري أو
+
+72
+00:06:39,710 --> 00:06:43,950
+التجويض العلمي وهو معرفة قواعد وأحكام علم التجويض
+
+73
+00:06:43,950 --> 00:06:49,090
+الموجودة في كتب التجويض وحكم التجويض النظري أو
+
+74
+00:06:49,090 --> 00:06:52,930
+التجويض العلمي ما هو حكمه؟ هل هو فرض على الكفاية
+
+75
+00:06:52,930 --> 00:06:56,210
+ولا فرض عين؟ فضل أخت
+
+76
+00:06:59,530 --> 00:07:06,230
+حكم التجويض النظري فرض كفاية إذا قام بيه بعض
+
+77
+00:07:06,230 --> 00:07:10,190
+المسلمين سقط على الأخرين لكن بالنسبة لكم أنتم
+
+78
+00:07:10,190 --> 00:07:13,890
+كطالبات علم في هذه الجامعة العريقة الجامعة
+
+79
+00:07:13,890 --> 00:07:18,760
+الإسلامية يعني هو بالنسبة لكم فرض عينلذلك بناخد
+
+80
+00:07:18,760 --> 00:07:23,180
+الامتحانات و بندرس هذا العلم و فيه هناك من ينجح في
+
+81
+00:07:23,180 --> 00:07:26,900
+الامتحان و منهم يرسل في الامتحان إذا ليس بالنسبة
+
+82
+00:07:26,900 --> 00:07:31,100
+لكم امتحان فرض كفاية لأن لو كان بالنسبة لكم فرض
+
+83
+00:07:31,100 --> 00:07:34,260
+كفاية يعني بيكفي واحدة من الأخوات تنجح و كلكم
+
+84
+00:07:34,260 --> 00:07:38,420
+ناجحين لكن هو فرض عين كل واحدة ملزمة أن تقدم فيه
+
+85
+00:07:38,420 --> 00:07:43,040
+امتحان و تدرسه جيدا و تتقدم إما أن تنجحوا إما أن
+
+86
+00:07:43,040 --> 00:07:49,690
+ترسلواإذا حكم علم التجويض النضري فرض كفاية إذا قام
+
+87
+00:07:49,690 --> 00:07:53,750
+به بعض الناس سقطة عن الآخرين يعني أنتم في الجامعة
+
+88
+00:07:53,750 --> 00:07:59,770
+تدرسوا هذا العلم لكنه غير مطلوب من أمك مثلا أو ناس
+
+89
+00:07:59,770 --> 00:08:03,850
+في الشوارع أو كده أن تدرس هذه المادة يعني بشكل
+
+90
+00:08:03,850 --> 00:08:08,890
+الزامي ليس فرضاين يعني أنتم كطالبات علم تسدوا عند
+
+91
+00:08:08,890 --> 00:08:14,000
+سائر المسلمين في كل واحدة في منطقتهأما بالنسبة
+
+92
+00:08:14,000 --> 00:08:19,320
+للقسم الثاني وهو التجويض التطبيقي أو التجويض
+
+93
+00:08:19,320 --> 00:08:24,740
+العملي .. العملي هذا التجويض التطبيقي هو تطبيق
+
+94
+00:08:24,740 --> 00:08:28,740
+أحكام التجويضالعلمية التي أخذناها في أحكام التجويض
+
+95
+00:08:28,740 --> 00:08:32,960
+على القرآن الكريم يعني نطبق الأحكام التي أخذناها
+
+96
+00:08:32,960 --> 00:08:38,480
+على القرآن الكريم فنقرأ القرآن مجودا وفق ما أخذنا
+
+97
+00:08:38,480 --> 00:08:43,280
+من الأحكام إذا التجويض العملي هو تطبيق أحكام
+
+98
+00:08:43,280 --> 00:08:47,400
+التجويض العلمية على تلاوة القرآن الكريم مجودا كما
+
+99
+00:08:47,400 --> 00:08:54,020
+أنزل على محمد صلى الله عليه وسلمو كما أخدنا حكم
+
+100
+00:08:54,020 --> 00:08:58,000
+التجويض النظري هناخد حكم التجويض .. إيش يا أخوان؟
+
+101
+00:08:58,000 --> 00:09:03,360
+العمل .. ما هو حكم التجويض العملي؟ هل هو فرض كفاية
+
+102
+00:09:03,360 --> 00:09:05,780
+ولا فرض عين؟ فضل أختي
+
+103
+00:09:09,770 --> 00:09:14,690
+أحسنتي الحكم التجويض هو واجب يعني فرض عين على كل
+
+104
+00:09:14,690 --> 00:09:19,330
+مسلم مكلف عليه أن يقرأ القرآن مجودا لأحكام التجويض
+
+105
+00:09:19,330 --> 00:09:23,530
+يعني مطبقا أحكام التجويض على الآيات القرآنية التي
+
+106
+00:09:23,530 --> 00:09:28,810
+يقرؤها والأدلة على ذلك من الكتاب والسنة والإجماع
+
+107
+00:09:28,810 --> 00:09:33,130
+أما من الكتاب يعني الله سبحانه و تعالى يقول ورتل
+
+108
+00:09:33,130 --> 00:09:38,530
+القرآن ترتيلافي معنى أمره من الله عز وجل إذا أردنا
+
+109
+00:09:38,530 --> 00:09:44,210
+أن نقرأ القرآن أن نقرأه مجودا ومرتلا كما قال تعالى
+
+110
+00:09:44,210 --> 00:09:51,110
+ورتل القرآن ترتيلا أي قرأه مجودا مطمئنا بكل هدوء
+
+111
+00:09:51,110 --> 00:09:57,290
+وكل خشوع مطبقا الأحكام التجويض التي تم أخذها كذلك
+
+112
+00:09:57,290 --> 00:10:02,290
+آية أخرى من يقرأهاقال الله تعالى اللذين آتينهم
+
+113
+00:10:02,290 --> 00:10:10,790
+الكتابة يتلونه حق تلاوته وحق
+
+114
+00:10:10,790 --> 00:10:16,310
+تلاوة القرآن يقراهم مجودا بمعنى مطبقا لأحكام
+
+115
+00:10:16,310 --> 00:10:21,870
+التجهيد هذا الدليل على وجوب قراءة القرآن مجودا من
+
+116
+00:10:21,870 --> 00:10:26,270
+الكتابةأما الدليل على وجوب قراءة القرآن مجوذا من
+
+117
+00:10:26,270 --> 00:10:32,590
+السنة فهو ما ورد عن ابل مسعود عبدالله ابن مسعودأنه
+
+118
+00:10:32,590 --> 00:10:37,290
+كان يقرئ رجلا من المسلمين يقرئه القرآن فقرأ الرجل
+
+119
+00:10:37,290 --> 00:10:44,090
+قوله تعالى إنما الصداقات للفقراء والمساكين يمد
+
+120
+00:10:44,090 --> 00:10:50,190
+كلمة للفقراء لأن الفقراء .. هذا في حرف المد وجاء
+
+121
+00:10:50,190 --> 00:10:54,110
+وراه .. الهمزة في كلمة واحدة .. إيش بيكون عنه
+
+122
+00:10:54,110 --> 00:10:57,250
+الحكومة؟ مدواجب متصل .. مدواجب متصل .. يعني عليه
+
+123
+00:10:57,250 --> 00:11:02,880
+أن يقولللفقراء والمساكين لكنه قرأها بدون أن يمد
+
+124
+00:11:02,880 --> 00:11:08,930
+كلمة الفقراء فاعترض عليه عبدالله بن مسعودقال له ما
+
+125
+00:11:08,930 --> 00:11:12,470
+هكذا أقرأنيها رسول الله صلى الله عليه و سلم قال
+
+126
+00:11:12,470 --> 00:11:17,330
+وكيف أقرأكها يا ابن مسعود قال أقرأنيها هكذا إنما
+
+127
+00:11:17,330 --> 00:11:23,730
+الصداقات للفقراء والمساكين فمد كلمة الفقراء إما
+
+128
+00:11:23,730 --> 00:11:27,450
+نجد هنا يا أخوات أن عبد الله بن مسعود اعترض على
+
+129
+00:11:27,450 --> 00:11:31,890
+الصحابي أو تلميذه الذي يعلمه القرآن لأنه لم يمد
+
+130
+00:11:31,890 --> 00:11:37,510
+كلمةللفقراء أو للفقراء فقال مها كذا أقرأنيه دلالة
+
+131
+00:11:37,510 --> 00:11:41,590
+على أن القرآن لابد أن يقرأ مجودا لأن النبي عليه
+
+132
+00:11:41,590 --> 00:11:47,030
+الصلاة والسلام علمه للصحابة مجودا والصحابة علموه
+
+133
+00:11:47,030 --> 00:11:52,430
+للتابعين أيضا مجودا أما بالنسبة للإجماع فقد أجمعت
+
+134
+00:11:52,430 --> 00:11:58,720
+الأمةعلى وجوه بقراءة القرآن الكريم مجودا مطبقا
+
+135
+00:11:58,720 --> 00:12:04,200
+لأحكام التجويض إذا عندنا دليل من الكتاب والسنة
+
+136
+00:12:04,200 --> 00:12:09,060
+وإجماع على وجوه بقراءة القرآن الكريم مجودا وهذا
+
+137
+00:12:09,060 --> 00:12:14,680
+الذي جعل ابن الجزري يقول والأخذ بالتجويض حكم لازم
+
+138
+00:12:14,680 --> 00:12:19,860
+من لم يجودوا القرآن آتما أما بالنسبة يا أخوات
+
+139
+00:12:19,860 --> 00:12:26,660
+لموضوع علم التجويضيعني ما هو الموضوع الذي ندرسه في
+
+140
+00:12:26,660 --> 00:12:30,880
+مادة أو مسافة علم التجويض ندرس إيش؟ فضل أختي
+
+141
+00:12:35,220 --> 00:12:39,620
+أحسنتي يعني إحنا ندرس في هذا المادة وفي هذا المساق
+
+142
+00:12:39,620 --> 00:12:44,000
+وهو علم التجويض النظري ندرس كلمات القرآن الكريم من
+
+143
+00:12:44,000 --> 00:12:49,640
+حيث إخراجه كل حرف من مخرجه وإعطاه حقه ومستحقه من
+
+144
+00:12:49,640 --> 00:12:54,820
+الصفات بمعنى أننا يعني نطبق أحكام التجويض وندرسها
+
+145
+00:12:54,820 --> 00:13:02,050
+دراسة صحيةكذلك لو قولنا من هو أول من أسس علم
+
+146
+00:13:02,050 --> 00:13:06,210
+التجويض أو أول من وضع علم التجويض؟ يعني هنكون
+
+147
+00:13:06,210 --> 00:13:11,980
+النظري مثلا، تفضليأول من وضع علم التجوذ أخوات هو
+
+148
+00:13:11,980 --> 00:13:16,000
+سيدنا محمد صلى الله عليه وسلم الذي كان يتلقى
+
+149
+00:13:16,000 --> 00:13:20,840
+القرآن من سيدنا جبريل وسيدنا جبريل كان يعطيه
+
+150
+00:13:20,840 --> 00:13:26,580
+القرآن مطبقا ومجودا الرسول يأخذه مجودا ويعلمه
+
+151
+00:13:26,580 --> 00:13:31,260
+للصحابة مجودا الصحابة كانوا يأخذونه مجودا ويعلمونه
+
+152
+00:13:31,520 --> 00:13:36,160
+لأتباعهم أيضًا مجودًا فأول من وضع علم التجويض
+
+153
+00:13:36,160 --> 00:13:40,960
+العملي التطبيقى محمد صلى الله عليه وسلم بل يمكننا
+
+154
+00:13:40,960 --> 00:13:47,000
+أن نقول أول علم من علوم القرآن هو علم التجويض لأنه
+
+155
+00:13:47,000 --> 00:13:53,100
+كان هذا العلم ظهورهمرافقا لنزول القرآن لأنه كان
+
+156
+00:13:53,100 --> 00:13:56,040
+القرآن ينزل مجودا والرسول عليه الصلاة والسلام
+
+157
+00:13:56,040 --> 00:14:04,460
+يعلمه للصحابة مجودا هذا بالنسبة للتجويض العملي لكن
+
+158
+00:14:04,460 --> 00:14:10,380
+بعد مائة سنة جاء مجموعة من العلماء وأخذوا يستنبطوا
+
+159
+00:14:10,380 --> 00:14:14,920
+أحكام التجويض من علم التجويض من القرآن الكريم أو
+
+160
+00:14:14,920 --> 00:14:17,620
+من تلاوة الرسول عليه الصلاة والسلام الذي كان
+
+161
+00:14:17,620 --> 00:14:22,610
+يعلمها للصحابةالصحابة نقلوا علم التجويض أو تجويض
+
+162
+00:14:22,610 --> 00:14:26,910
+مجودا جاء مجموع من العلماء واستنبطوا الأحكام
+
+163
+00:14:26,910 --> 00:14:32,950
+والقواعد من الصحابة اللي كانوا يقرؤوه على الرسول
+
+164
+00:14:32,950 --> 00:14:36,530
+صلى الله عليه وسلم فاستنبطوا علم التجويض من ضمن
+
+165
+00:14:36,530 --> 00:14:40,210
+أحكام الليول الساكن والتنوين أحكام المدود التفخيم
+
+166
+00:14:40,210 --> 00:14:44,340
+والترقيق و أحكام الوقف والابتداء وغير ذلكمن
+
+167
+00:14:44,340 --> 00:14:50,240
+الأحكام لكن أول من وضع علم التجويض النظري كأحكام
+
+168
+00:14:50,240 --> 00:14:53,500
+وقواعد واصنباطات من هو .. تفضلي
+
+169
+00:14:58,310 --> 00:15:02,810
+أحسن، إذن يا أخوات، يعني .. يعني مجموعة من
+
+170
+00:15:02,810 --> 00:15:07,470
+العلماء، كل عالم استنبطى أحكام معينة، لكنهم ..
+
+171
+00:15:07,470 --> 00:15:12,630
+لذلك ظهر العلم مجزئا بداية الأمر، ولكن أول من ظهر
+
+172
+00:15:12,630 --> 00:15:17,670
+.. أظهر علم التجويض النظري، هو قيلة أنه أبو الأسود
+
+173
+00:15:17,670 --> 00:15:22,310
+الدوليوقيل هو أبو عبيد القاسم عليه السلام وقيل
+
+174
+00:15:22,310 --> 00:15:26,690
+الخليل ابن أحمد الفراهيدي قد يكون كلهم .. كل واحد
+
+175
+00:15:26,690 --> 00:15:31,790
+شارك في استنباط أحكام التجويض وقد يكون غيرهم لكن
+
+176
+00:15:31,790 --> 00:15:36,710
+هذه الأسماء هي التي وردت إلينا لابد أن يكون لهم
+
+177
+00:15:36,710 --> 00:15:41,530
+سهم في إخراج هذا العلم لكن العلم لم يخرجه واحدمن
+
+178
+00:15:41,530 --> 00:15:45,630
+المسلمين وانما مشتركين كل واحد من العلماء استنبط
+
+179
+00:15:45,630 --> 00:15:50,370
+أحكام فجاء بعد ذلك مجموع من العلماء و ألفوا كتب في
+
+180
+00:15:50,370 --> 00:15:55,350
+علم التجويض جمعوا كل ما استنبطه العلماء السابقين
+
+181
+00:15:55,350 --> 00:16:00,750
+في كتاب واحد وسموه طبعا اللي هو أحكام التجويضأما
+
+182
+00:16:00,750 --> 00:16:05,010
+نسبة علم التجويض يا أخوات علم التجويض هو له فضل
+
+183
+00:16:05,010 --> 00:16:09,450
+عظيم وهو أشرف العلوم الشرعية المتعلقة بكتاب الله
+
+184
+00:16:09,450 --> 00:16:13,850
+وأفضلها لاختصاصه بكيفية قراءة القرآن الكريم، إذا
+
+185
+00:16:13,850 --> 00:16:21,040
+علم التجويض يعني أشرفالعلوم لأن شرف العلم من شرف
+
+186
+00:16:21,040 --> 00:16:25,320
+المعلوم المعلوم اللي هو القرآن الكريم فالقرآن
+
+187
+00:16:25,320 --> 00:16:29,940
+الكريم شريف وكل دراسة تتعلق بالقرآن الكريم هتكون
+
+188
+00:16:29,940 --> 00:16:34,580
+أيضا شريفة لذلك أشرف العلم هو علم التجويض لأنه
+
+189
+00:16:34,580 --> 00:16:39,640
+يتعلق بكيفية قراءة القرآن الكريم الذي لنا به أجر
+
+190
+00:16:39,640 --> 00:16:45,710
+عظيم في تلاوة هذا القرآنكما يقول النبي عليه الصلاة
+
+191
+00:16:45,710 --> 00:16:50,070
+والسلام، من قرأ حرفا من كتاب الله تعالى له به
+
+192
+00:16:50,070 --> 00:16:55,450
+حسنة، والحسنة بعشر أمثالها، لا أقول ألف لام ميم
+
+193
+00:16:55,450 --> 00:17:00,560
+حرف، ولكن ألف حرف، لام حرف، ميم حرفأما بالنسبة
+
+194
+00:17:00,560 --> 00:17:04,980
+للثمة علم التجويض يعني أول شيء قراءة القرآن مجودا
+
+195
+00:17:04,980 --> 00:17:10,520
+كذلك نستفيد من حافظ القرآن وكان يقرأ القرآن مجودا
+
+196
+00:17:10,520 --> 00:17:16,020
+أو درس أحكام التجويض هنجده يعني يهذب الألفاظ تهذيب
+
+197
+00:17:16,020 --> 00:17:20,300
+الألفاظ وتقويم اللسان وصونه من اللحن في ألفاظ
+
+198
+00:17:20,300 --> 00:17:23,840
+القرآن الكريم يعني الذي يدرس أحكام التجويض يعني
+
+199
+00:17:23,840 --> 00:17:30,120
+يخرج كل حرف من مخرجه لا يقول ذلك الكتابولا .. بل
+
+200
+00:17:30,120 --> 00:17:35,060
+يقول ذلك الكتاب لأن حرف ذال يعني له مخرج متخصص لا
+
+201
+00:17:35,060 --> 00:17:41,900
+يقول سيبات وأبكارة يقول ثيبات وأبكارة لا يقولوا
+
+202
+00:17:41,900 --> 00:17:46,400
+الإثم .. لا يقولوا الإسم بل يقولوا الاثم فحرف الث
+
+203
+00:17:46,400 --> 00:17:52,240
+ث وليس س عندنا بعض الناس يخرجوا هذه الحروف من غير
+
+204
+00:17:52,240 --> 00:18:01,620
+مخرجها يقول ظهر الحقليس زهرة بل ظهرة كذلك نقول ذلك
+
+205
+00:18:01,620 --> 00:18:08,440
+الكتاب ولا نقول ذلك الكتاب نقول ثم ولا نقول ثم
+
+206
+00:18:08,440 --> 00:18:14,140
+وهذا ما يسمى باللحن في القرآن الكريم ومعنى اللحن
+
+207
+00:18:14,140 --> 00:18:19,340
+هو الخطأ في القرآن الكريم ننتقل إلى موضوع اللحن
+
+208
+00:18:19,340 --> 00:18:24,950
+وهو بمعنى الخطأفي تلاوة القرآن الكريم أو الخطأ في
+
+209
+00:18:24,950 --> 00:18:30,790
+إخراج الحرف من المخرجين ما معنى اللحن يا أخوات؟
+
+210
+00:18:30,790 --> 00:18:31,130
+فضلي
+
+211
+00:18:35,980 --> 00:18:42,900
+أحسن من حيث اللغة معنى فلان يلحن بمعنى فلان يخطئ
+
+212
+00:18:42,900 --> 00:18:47,380
+فمعنى اللحن من حيث اللغة هو الخطأ ومخالفة الصواب
+
+213
+00:18:47,380 --> 00:18:52,100
+ومعنى اللحن في الاصطلاح هو الخطأ الذي يطرأ على
+
+214
+00:18:52,100 --> 00:18:56,720
+اللفظ القرآني يعني فلان يلحن بمعنى أخرج الحرف من
+
+215
+00:18:56,720 --> 00:19:01,740
+غير مخرجه بدأ من أن يقول ذلك الكتاب قال ذلك الكتاب
+
+216
+00:19:01,740 --> 00:19:07,940
+فلحن في قراءتهواللحن في هناك له أقسام لو سألنا
+
+217
+00:19:07,940 --> 00:19:16,100
+الأخوات ما هي أقسام اللحن؟ يبقى قسم اللحن إلى
+
+218
+00:19:16,100 --> 00:19:22,020
+قسمين أولا اللحن الجلي ومن كلمة جلي يعني ظاهر
+
+219
+00:19:22,020 --> 00:19:26,780
+وواضح والكل يعرفه سواء كان العلماء أم العامة يعني
+
+220
+00:19:26,780 --> 00:19:31,560
+لو واحد قال ذلك العامة و العلماء يعلمون أن هذا خطأ
+
+221
+00:19:31,710 --> 00:19:37,850
+لو واحد قال صراط الذين أنعمت عليهم نعرف أن هذا خطأ
+
+222
+00:19:37,850 --> 00:19:43,590
+لأنه ليس صراط الذين أنعمت بل صراط الذين أنعمت
+
+223
+00:19:43,590 --> 00:19:49,630
+عليهم إذا لحن جلي واضح يعلمه العلماء والعامة
+
+224
+00:19:49,630 --> 00:19:54,590
+الجميع يعلمه لذلك سمى لحن جلي إذا اللحن الجلي من
+
+225
+00:19:54,590 --> 00:20:00,760
+حيث اللغة هو الخطأ الواضح والظاهرأما اللحن الجلي
+
+226
+00:20:00,760 --> 00:20:04,880
+من حيث الاصطلاح هو الخطأ الذي يطرأ على اللفظ
+
+227
+00:20:04,880 --> 00:20:10,040
+القرآني فيخل بمبنى الكلمة وعُرف القراءة سواء خل
+
+228
+00:20:10,040 --> 00:20:14,580
+بالمعنى أم لم يخل إذا اللحن الجلي هو الخطأ الذي
+
+229
+00:20:14,580 --> 00:20:19,760
+يطرأ على اللفظ القرآني فيخل بمبنى الكلمة ما معنى
+
+230
+00:20:19,760 --> 00:20:26,170
+فيخل بمبنى الكلمة؟يعني في أصل الكلمة يعني مثلا من
+
+231
+00:20:26,170 --> 00:20:33,070
+أن يقول مثلا ثيباتي وأبكرا قال سيبات غير حرف في
+
+232
+00:20:33,070 --> 00:20:38,370
+فرق بين ثيبات وسيبات في كذلك بتغير المعنى كذلك
+
+233
+00:20:38,370 --> 00:20:45,770
+الإثم والاسم لو قال الاثم ما معنى الاثم؟هو الذنب
+
+234
+00:20:45,770 --> 00:20:49,250
+.. الذنب فلان يرتكب ذنب اثمان يعني ارتكب ذنبا ..
+
+235
+00:20:49,250 --> 00:20:54,250
+الاسم من الأسماء .. اسم فلان واسم فلان .. اذا
+
+236
+00:20:54,250 --> 00:20:58,450
+اتغير مبنى الكلمة وعرف القراءة .. يعني هو الخطأ
+
+237
+00:20:58,450 --> 00:21:03,270
+الذي يطرق على اللفظ القرآني فيخل بمبنى الكلمة وعرف
+
+238
+00:21:03,270 --> 00:21:06,910
+القراءة .. اعرف المبنى بالكلمة يعني غيرنا حرف محل
+
+239
+00:21:06,910 --> 00:21:11,860
+حرفحركة في الحرف جلبت المعنى و هكذا أما بالنسبة
+
+240
+00:21:11,860 --> 00:21:16,700
+لعرف القراءة بمعنى اللي هو أحكام التجويض يعني أخطأ
+
+241
+00:21:16,700 --> 00:21:20,260
+في أحكام التجويض مثل ما حصل مع عبد الله بن مسعود
+
+242
+00:21:20,260 --> 00:21:24,720
+لما سمع الصحابي يقرأ إنما الصداقات للفقراء
+
+243
+00:21:24,720 --> 00:21:29,900
+والمساكين بدون ما يمذب كلمة ال للفقراء قال ما هكذا
+
+244
+00:21:29,900 --> 00:21:34,480
+أقرأنيها رسول الله صلى الله عليه وسلم وعلموا أن
+
+245
+00:21:34,480 --> 00:21:41,680
+هذه إعبارة للفقراءعلى أساس أنه فيها مدء، إذا هذا
+
+246
+00:21:41,680 --> 00:21:46,540
+هو تعريف اللحن الجلي في عندنا أمثل يا أخوات على
+
+247
+00:21:46,540 --> 00:21:52,720
+اللحن الجلي أول شيء مثلا الخطأ الجلي المخل
+
+248
+00:21:52,720 --> 00:21:57,440
+بالمعنى، في خطأ جلي مخل بالمعنى وفي خطأ جلي غير
+
+249
+00:21:57,440 --> 00:22:02,510
+مخل بالمعنىيعني لو قولنا الاسم بدل الاثم أخل
+
+250
+00:22:02,510 --> 00:22:08,290
+بالمعنى، لو قولنا سي .. سيبات بدل سيبات وأبكرة
+
+251
+00:22:08,290 --> 00:22:13,870
+بيخل بالمعنى، كذلك من ضمن الأمثلة مثلا صراط الذين
+
+252
+00:22:13,870 --> 00:22:20,130
+أنعمت عليهم، لو واحدة قرأتها صراط الذين أنعمت
+
+253
+00:22:20,130 --> 00:22:28,540
+عليهم، بيصير الفاعل من؟أنا طب أنعمتى عليهم الفاعل
+
+254
+00:22:28,540 --> 00:22:33,600
+أنتى لكن هل هو هذا المراد؟ غير المراد المراد صراط
+
+255
+00:22:33,600 --> 00:22:38,660
+الذين أنعمتى عليهم والمنعم هو الله سبحانه وتعالى
+
+256
+00:22:38,660 --> 00:22:43,520
+لأ أنا ولا أنتى فالمنعم هو الله عزوجل لذلك نقول
+
+257
+00:22:43,520 --> 00:22:49,140
+هذا اللحن يخلو بالمعنى ولكن الإخلال بالمعنى هنا
+
+258
+00:22:49,140 --> 00:22:53,440
+إخلال فاحشكيف بيكون الإخلال فحش في هذا المعنى صلات
+
+259
+00:22:53,440 --> 00:22:58,440
+الذين أنعمت عليه بغرها أنعمته؟ لأنه بتغير المعنى،
+
+260
+00:22:58,440 --> 00:23:03,520
+لذلك أقول العلماء من أخطأ و لحن في الفاتحة لأنه في
+
+261
+00:23:03,520 --> 00:23:08,660
+الفاتحة فلحن لحن جليا أخلى بالمعنى فصلاته باطلة
+
+262
+00:23:09,300 --> 00:23:13,880
+بطبطب صلاته ومن هنا بترتب علينا أننا يجب علينا أن
+
+263
+00:23:13,880 --> 00:23:18,660
+نتعلم أحكام التجويد لنقرأ القرآن قراءة سليمة لو
+
+264
+00:23:18,660 --> 00:23:23,960
+واحد مثلا صلّى صلاته العادية وبدأ من أن يقول صلاة
+
+265
+00:23:23,960 --> 00:23:29,120
+الذين أنعمت عليهم قال صلاة الذين أنعمت عليهم
+
+266
+00:23:29,120 --> 00:23:34,040
+فصلاته باطلة لأن ليس أنت الذي أنعمت بل الله سبحانه
+
+267
+00:23:34,040 --> 00:23:39,850
+وتعالى هو الذي أنعم عليهمطب في عندنا كذلك خطأ جالي
+
+268
+00:23:39,850 --> 00:23:45,790
+لا يخل بالمعنى لكنه إخلال في الكلمة يعني لحن فيها
+
+269
+00:23:45,790 --> 00:23:54,010
+أخطأ فيها لكنه لا يخل بالمعنى مثل ماذا؟الان لم يلد
+
+270
+00:23:54,010 --> 00:24:01,110
+ولم يولد لو حركها قال لم يلد ولم يولد او لم يلد
+
+271
+00:24:01,110 --> 00:24:06,210
+ولم يولد اتغير المعنى؟ لم يتغير المعنى، اذا لم
+
+272
+00:24:06,210 --> 00:24:12,770
+يخيل .. هو لحن جليللكنه لا يخله بالمعنى لذلك و هو
+
+273
+00:24:12,770 --> 00:24:18,410
+معيب و يعده خطأ و لا تصح قراءته و لا إمامته و يأثر
+
+274
+00:24:18,410 --> 00:24:23,230
+مفاعله مع الإصرار هدى بالنسبة للذي يلحن لحنا جانيا
+
+275
+00:24:23,230 --> 00:24:29,510
+صمي لحن جاني طبعا لأنه يشترك في معرفته العلماء و
+
+276
+00:24:29,510 --> 00:24:33,490
+العامة طيب اللحن الجاني يعني عام اللحن الجاني يا
+
+277
+00:24:33,490 --> 00:24:40,210
+أخوات هو يعني إبدال حرف بحرفمثلا قوله ايه؟ الحمد
+
+278
+00:24:40,210 --> 00:24:48,210
+لله رب العالمين لو واحد أبدل حرف الها بالها فقال
+
+279
+00:24:48,210 --> 00:24:53,610
+الحمد لله .. الحمد لله طبعا هذا لحن، حرف الحا
+
+280
+00:24:53,610 --> 00:25:00,150
+أبدلها بها لحن لحنا جاليا، يعني هذا خطأ لكن لو كان
+
+281
+00:25:00,150 --> 00:25:07,070
+مثلا .. هذا ممكن يحصل مع بعض العجمأو الأج .. أجنبي
+
+282
+00:25:07,070 --> 00:25:12,130
+لأنه ليس عندهم حرف الح .. الح حرف تتميز به اللغة
+
+283
+00:25:12,130 --> 00:25:16,750
+العربية هم يقرؤونه كما هو الكتابة عندهم يعني لو
+
+284
+00:25:16,750 --> 00:25:20,510
+أردنا أن نكتب الحمد باللغة الإنجليزية بحروف
+
+285
+00:25:20,510 --> 00:25:26,150
+إنجليزية و بألفاب عربية فبنكتب H الحمد لله فيأتي
+
+286
+00:25:26,150 --> 00:25:30,230
+.. يأتي هذا اللي أسلم جديد مثلا يقراها الحمد لله
+
+287
+00:25:30,690 --> 00:25:36,650
+لكن مقبولة منه إذا كان في مثله في بداية الإسلام و
+
+288
+00:25:36,650 --> 00:25:40,730
+مع مثله لو كان كلهم بيقرأوا هذه الكلمة هكذا مع
+
+289
+00:25:40,730 --> 00:25:45,210
+مثله تقبل منه على أن يتعلم أحكام التجويل لكن واحد
+
+290
+00:25:45,210 --> 00:25:50,950
+عندنا من العرب قال الحمد لله نقول إن هذه يعني لحن
+
+291
+00:25:50,950 --> 00:25:56,370
+جلي في الحروف أبدلنا حرف مح الحرف لا تصحه قراءته و
+
+292
+00:25:56,370 --> 00:26:00,360
+طبعا و هذا صحيح في ال .. نجد أنه كثيرمن الناس في
+
+293
+00:26:00,360 --> 00:26:07,580
+العامة يخطئوا فيلفظوا حروف بخطأ وهذا طبعا ليس
+
+294
+00:26:07,580 --> 00:26:12,780
+صحيحا مثلا حرف القاف .. حرف القاف قد يلفظها بعض
+
+295
+00:26:12,780 --> 00:26:17,880
+الناس في العامية عندنا نقول عن القاف gaو بدل من أن
+
+296
+00:26:17,880 --> 00:26:23,200
+نقول قال نقول جال .. و هذا خطأ .. خطأ بالنسبة
+
+297
+00:26:23,200 --> 00:26:27,340
+العامية ممكن ليس قرآنا .. يعني نقول فلان جالي ..
+
+298
+00:26:27,340 --> 00:26:31,280
+طبيعي .. لكن إذا كان في القرآن الكريم لا يجوز أن
+
+299
+00:26:31,280 --> 00:26:35,920
+نقول اهدنا الصراط المستقيم بل علينا أن نقول اهدنا
+
+300
+00:26:35,920 --> 00:26:41,380
+الصراط المستقيم فالقاف تخرجه من مخرجهاوهو أقصى
+
+301
+00:26:41,380 --> 00:26:45,020
+اللسان مع ميحذية من الحناك الأعلى لا نقول المستجيم
+
+302
+00:26:45,020 --> 00:26:51,120
+إذا حرف القاف لا يصح لنا أن نرفضه ga بالإنقليزي
+
+303
+00:26:51,120 --> 00:26:57,520
+كذلك حرف الجيم حرف الجيم قد يلفظه بعض الناس مثل
+
+304
+00:26:57,520 --> 00:27:04,460
+الجيم المصرية نقول وجاء رجل كلمة وجاء رجل من أقصى
+
+305
+00:27:04,460 --> 00:27:10,650
+المدينة خطأهي و جاء رجل حرف ال ج يخرجه من مخرجه
+
+306
+00:27:10,650 --> 00:27:16,170
+وهو وسط اللسان فلا نخرج حرف الجيم ج أو ال ج
+
+307
+00:27:16,170 --> 00:27:20,930
+المصرية فهذا لا يصح لنا و يعد لحنا جاليا كذلك
+
+308
+00:27:20,930 --> 00:27:28,730
+إبدال حرف الثسين مثل قوله تعالى ثيباتي و أذكارا
+
+309
+00:27:29,240 --> 00:27:34,500
+ثيبات، لا نقوله سيبات، لأن السيب يعني المهمل
+
+310
+00:27:34,500 --> 00:27:39,480
+المتروكة، لكن الثيب بمعنى المرأة الثيب المتزوجة
+
+311
+00:27:39,480 --> 00:27:46,460
+كذلك ابدأوا حرف النون بحرف اللام، فحرف اللام يعني
+
+312
+00:27:46,460 --> 00:27:49,960
+لا يصح لنا أن نبدأ اللام نون ولا حتى نون لام مثلا
+
+313
+00:27:49,960 --> 00:27:56,700
+صراط الذين أنعمتتبدل لو أبدل واحد حرف النون الام
+
+314
+00:27:56,700 --> 00:28:04,720
+فقال صراط الذين ألعمتهذا بتحدث مع من؟ ولد صغير في
+
+315
+00:28:04,720 --> 00:28:10,840
+الروضة صراط الذين أنعمت عليهم طبعا على الأم مثلا
+
+316
+00:28:10,840 --> 00:28:15,720
+أو الوالدين أو المربي أن يعلمه يقرأ قراءة سليمة
+
+317
+00:28:15,720 --> 00:28:21,400
+صراط الذين أنعمت عليهم وليس أنعمت عليهم لو قالها
+
+318
+00:28:21,400 --> 00:28:25,700
+.. نقوم لسانه لأنه أولاد صغير لكن المشكلة لو قالها
+
+319
+00:28:25,700 --> 00:28:32,660
+رجل كبيرفهذا خطأ كبير لأنه خطأ الكبير كبير كذلك من
+
+320
+00:28:32,660 --> 00:28:38,980
+ضمن اللحن الأخوات مثلا ابدا الحرف الذال زاه مثل
+
+321
+00:28:38,980 --> 00:28:46,940
+صراط الذين أنعمت عليهم لو قال صراط الذين فقال
+
+322
+00:28:46,940 --> 00:28:53,730
+الذين وهذا خطأ هي الذينو احنا بلاد الشام و مصر
+
+323
+00:28:53,730 --> 00:28:58,090
+كثير عما يخطبوا الناس بهذه الحروف نقول عن الذال
+
+324
+00:28:58,090 --> 00:29:05,610
+زاي بدل الذين الذين و بدل ثمة نقول ثمة و بدل الض
+
+325
+00:29:05,610 --> 00:29:12,970
+نقول ز زهرة و ليس زهرة و انما ظهرةكذلك من ضمن
+
+326
+00:29:12,970 --> 00:29:19,910
+الأخطاء حرف القاف يلفظ غين هذا لحن الجني مثال ذلك
+
+327
+00:29:19,910 --> 00:29:29,770
+إن أنزلناه في ليلة القدر لو واحد قال إن أنزلناه في
+
+328
+00:29:29,770 --> 00:29:34,530
+ليلة الغدرعندنا في بلادنا عندنا لا نخطب حرف القاف
+
+329
+00:29:34,530 --> 00:29:41,350
+أما في السودان فبينفذوا حرف القاف غين يعني .. يعني
+
+330
+00:29:41,350 --> 00:29:45,770
+يقول لابد أن نعرف غدر الله و غدر رسوله طبعا هذا
+
+331
+00:29:45,770 --> 00:29:51,290
+بالنسبة لنا خطأإن هي قدر الله و قدر رسوله لأولى
+
+332
+00:29:51,290 --> 00:29:56,370
+لته القدر خير من ألف شهر ولا نقول الغدر لأن لفظ
+
+333
+00:29:56,370 --> 00:30:02,210
+اللي غيرنا الحرف إذا اللحن الجلي في الحروف أبطل
+
+334
+00:30:02,210 --> 00:30:06,490
+المعنى بدل من أن يكون القدر و المنزلة صار الغدر و
+
+335
+00:30:06,490 --> 00:30:12,000
+الخيانة فتغير المعنىكذلك يا أخوات في عندنا لحن
+
+336
+00:30:12,000 --> 00:30:17,740
+جالي بزيادة حرف معروف أن الزيادة أخ النقصان لو
+
+337
+00:30:17,740 --> 00:30:23,640
+زودنا حرف يكون يسمى لحن جالي و لو نقصنا حرف برضه
+
+338
+00:30:23,640 --> 00:30:28,180
+يسمى لحن جالي فلابد أن نخرج الحروف من مخرجها و
+
+339
+00:30:28,180 --> 00:30:35,650
+نعطيها حقها و مستحقها من الحروفمثلا زيادة الحرف ..
+
+340
+00:30:35,650 --> 00:30:40,450
+زيادة الحرف مثلا قوله تعالى أجيب دعوة الداعي إذا
+
+341
+00:30:40,450 --> 00:30:47,110
+دعان .. دعان .. نون لوها اتزود حرف و قال هي أصلها
+
+342
+00:30:47,110 --> 00:30:54,760
+دعاني فقال أجيب دعوة الداعي إذا دعانييكون هنا لحن
+
+343
+00:30:54,760 --> 00:31:01,400
+جلي في الحروف لأنه زود حرف أو نقص حرفا يسمى أيضا
+
+344
+00:31:01,400 --> 00:31:07,000
+لحن جلي بانقاص حرف من الحروف مثال ذلك قول تعالى
+
+345
+00:31:07,000 --> 00:31:13,840
+فلا تخشوهم واخشوني لو واحد قال لماذا تخشوني أحدف
+
+346
+00:31:13,840 --> 00:31:20,740
+اليا زي ذعان فأقول فلا تخشوهم واخشونبدون يا ..
+
+347
+00:31:20,740 --> 00:31:25,460
+أيضا هذا ماذا يسمى يا أخوات؟ يسمى لحنجلي وبالتالي
+
+348
+00:31:25,460 --> 00:31:30,140
+يعني أخطأ هذا القارئ بهذا الكلامهذا يا أخوات هو
+
+349
+00:31:30,140 --> 00:31:35,920
+اللحن الجلي في الحروف عندنا كذلك لحن جلي في
+
+350
+00:31:35,920 --> 00:31:41,180
+الكلمات وعنا لحن جلي في الحركات هذا ان شاء الله في
+
+351
+00:31:41,180 --> 00:31:45,540
+المحاضرات القادمة سوف ناخد اللحن الجلي في الكلمات
+
+352
+00:31:45,540 --> 00:31:49,020
+واللحن الجلي في الحركات ونكتفي بهذا القدر ونكمن ان
+
+353
+00:31:49,020 --> 00:31:51,440
+شاء الله في المحاضرة القادمة بارك الله فيكم
+
+354
+00:31:51,440 --> 00:31:53,780
+والسلام عليكم ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..de6e060ed3e7aadd50053095520186574dc3393a
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw.srt
@@ -0,0 +1,2011 @@
+1
+00:00:11,460 --> 00:00:15,180
+بسم الله الرحمن الرحيم الحمد لله و الصلاة و السلام على
+
+2
+00:00:15,180 --> 00:00:19,060
+رسول الله و على آله و صحبه وسلم موضوعنا اليوم يا 
+
+3
+00:00:19,060 --> 00:00:23,340
+أخوات عن مقدمة في علم التجويد أو مقدمة في علم
+
+4
+00:00:23,340 --> 00:00:27,910
+القراءات وحتى نستطيع أن ندرس هذا الموضوع دراسة
+
+5
+00:00:27,910 --> 00:00:33,730
+رسمية لابد أن نرجع قليلا إلى الوراء أخذنا سابقا أن
+
+6
+00:00:33,730 --> 00:00:39,290
+عثمان بن عفان وجد أو أن الأمة قد اختلفت في الأحرف
+
+7
+00:00:39,290 --> 00:00:44,810
+السبعة عندما اجتمع المسلمون في موطن من مواطن الجهاد
+
+8
+00:00:44,810 --> 00:00:50,140
+وهو أذربيجان وأرمينيا كان المسلمون مع بعضهم البعض 
+
+9
+00:00:50,140 --> 00:00:55,780
+فيما التابعين قد اختلفوا على الأحرف السبعة حتى 
+
+10
+00:00:55,780 --> 00:01:00,320
+كاد بعضهم أن يكفر بعضا لذلك حذيفة بن اليمان حضر هذا
+
+11
+00:01:00,320 --> 00:01:05,000
+المشهد فاستأذن من أمير الجند ورجع إلى الخليفة
+
+12
+00:01:05,000 --> 00:01:09,620
+عثمان بن عفان وقال له أذّكِر الأمة قبل أن يختلفوا
+
+13
+00:01:09,620 --> 00:01:14,540
+على كتاب ربهم كما اختلف اليهود و النصارى وفهم
+
+14
+00:01:14,540 --> 00:01:17,740
+الموضوع أن المسلمين يختلفون على الأحرف السبعة
+
+15
+00:01:18,920 --> 00:01:22,900
+فعثمان بن عفان جمع الصحابة و قال لهم اجتمعوا يا 
+
+16
+00:01:22,900 --> 00:01:27,420
+أصحاب محمد أنتم هاهنا تختلفون و أنتم في مدينة رسول 
+
+17
+00:01:27,420 --> 00:01:31,840
+الله صلى الله عليه وسلم فمن نقى عنكم كان أشد
+
+18
+00:01:31,840 --> 00:01:36,310
+اختلافا اجتمعوا يا أصحاب محمد حتى نجد حلا فلما
+
+19
+00:01:36,310 --> 00:01:40,110
+اجتمعوا و اتشاوروا قالوا لابد أن نجمع القرآن على
+
+20
+00:01:40,110 --> 00:01:44,210
+حرف واحد وهو حرف قريش فجمعوا القرآن على حرف قريش
+
+21
+00:01:44,210 --> 00:01:49,910
+وهو أبلغ الحروف وأفصحها ونسخوا نسخة يعني على حرف
+
+22
+00:01:49,910 --> 00:01:54,970
+واحد عثمان بن عفان طلب المصحف من السيدة حفصة أم 
+
+23
+00:01:54,970 --> 00:01:59,230
+المؤمنين رضي الله عنها ونسخ المصحف على حرف واحد
+
+24
+00:01:59,230 --> 00:02:04,430
+و جعل أربعة من الصحابة الكرام الشباب منهم الذين ينسخون 
+
+25
+00:02:04,430 --> 00:02:09,370
+هذه النسخ وهم زيد بن ثابت و عبدالله بن الزبير و
+
+26
+00:02:09,370 --> 00:02:13,410
+سعيد بن العاص و أبو عبد الرحمن أو عبد الرحمن بن حارث
+
+27
+00:02:13,410 --> 00:02:20,310
+بن هشام نسخوا المصحف على حرف واحد ثم نسخوا على سبع
+
+28
+00:02:20,310 --> 00:02:26,130
+نسخ وقيل خمس نسخ و أرسلوها إلى البلدان و الأنصار 
+
+29
+00:02:26,130 --> 00:02:32,130
+المجاورة فكان يرسل مع كل مصحف أحد المقرئين أرسل
+
+30
+00:02:32,130 --> 00:02:36,350
+عبد الله بن السائب المفزومي إلى مكة مع مصحف إلى 
+
+31
+00:02:36,350 --> 00:02:41,230
+مكة و أرسل مصحفا كذلك إلى الكوفة و أرسل معه مقرئا و
+
+32
+00:02:41,230 --> 00:02:44,670
+هو أبو عبد الرحمن السلمي و أرسل مصحفا آخر إلى
+
+33
+00:02:44,670 --> 00:02:49,640
+البصرة و أرسل معه عاصم ابن قيس و أرسل مصحفا آخر إلى 
+
+34
+00:02:49,640 --> 00:02:53,820
+الشام و أرسل معه المغيرة بن أبي شهاب المخزومي و 
+
+35
+00:02:53,820 --> 00:02:57,620
+أرسل مصحفا خامسا إلى المدينة المنورة و أرسل معه
+
+36
+00:02:57,620 --> 00:03:02,880
+زيد بن ثابت و قيل أنه أرسل كمان مصحفين مصحفا إلى
+
+37
+00:03:02,880 --> 00:03:07,840
+اليمن و مصحفا إلى البحرين المهم أنه مع كل مصحف من
+
+38
+00:03:07,840 --> 00:03:12,820
+المصحف العثمانية التي رسمت و التي نسخت أرسل معه
+
+39
+00:03:12,820 --> 00:03:18,190
+قارئا يقرأ للناس فاشتهر هذا القارئ وتتلمذ عليه آلاف
+
+40
+00:03:18,190 --> 00:03:23,390
+من الطلاب بعض الطلاب أصبحوا مشهورين وعلماء من 
+
+41
+00:03:23,390 --> 00:03:28,930
+أمثال مثلا عاصم بن أبي النجود الذي أخذ العلم عن
+
+42
+00:03:28,930 --> 00:03:32,150
+أبي عبد الرحمن السلمي فاشتهر .. اشتهر بعض
+
+43
+00:03:32,150 --> 00:03:35,990
+العلماء و بعض القراء فأصبح أولئك القراء يعني 
+
+44
+00:03:35,990 --> 00:03:41,930
+مشهورين و من هنا ظهر علم القراءات إذن متى ظهر علم
+
+45
+00:03:41,930 --> 00:03:47,730
+القراءات بعد أن أرسل عثمان بن عفان المصاحف وأرسل
+
+46
+00:03:47,730 --> 00:03:53,730
+مع كل مصحف مقرئا و .. وتعلم على يد هؤلاء المقرئين
+
+47
+00:03:53,730 --> 00:03:58,590
+علماء فاضل و أبدعوا في هذا العلم و اشتهروا ..
+
+48
+00:03:58,590 --> 00:04:02,550
+اشتهر بعضهم بطريقة معينة من أمثال عاصم بن ابن 
+
+49
+00:04:02,550 --> 00:04:06,930
+نجود الذي تلقى العلم عن أبي عبد الرحمن السلمي وهو
+
+50
+00:04:06,930 --> 00:04:12,570
+سند رواية حفص عن عاصم فنحن نأخذ روايتنا حفص بن 
+
+51
+00:04:12,570 --> 00:04:17,230
+سليمان عن عاصم بن أبي النجود عن أبي عبد الرحمن
+
+52
+00:04:17,230 --> 00:04:21,310
+السلمي عن علي بن أبي طالب عن رسول الله صلى الله 
+
+53
+00:04:21,310 --> 00:04:26,370
+عليه وسلم اشتهر هؤلاء الأئمة المقرئين فجاء ابن 
+
+54
+00:04:26,370 --> 00:04:33,090
+مجاهد وجمع أشهر سبع قراءات أو أشهر سبع أئمة من 
+
+55
+00:04:33,090 --> 00:04:38,600
+ضمنهم قراءة عاصم بن أبي النجود و ألف كتاب سماه 
+
+56
+00:04:38,600 --> 00:04:44,040
+السبعة في القراءات لابن مجاهد لذلك لو سألنا سؤالا 
+
+57
+00:04:44,040 --> 00:04:50,420
+من هو أول من سبع السبعة يعني أول من جمع سبع قراء
+
+58
+00:04:50,420 --> 00:04:55,360
+أو سبع قراءات في كتاب واحد اللي هو هيكون ابن مجاهد
+
+59
+00:04:55,360 --> 00:05:00,870
+هو أول من سبع السبعة ثم جاء يعني ابن الجزري بعد
+
+60
+00:05:00,870 --> 00:05:06,330
+فترة من الزمان فوجد أن هناك كمان ثلاث قراءات لها 
+
+61
+00:05:06,330 --> 00:05:12,190
+شروط متواترة يعني صحة سندها وحديث ورواية متواترة
+
+62
+00:05:12,190 --> 00:05:17,310
+وموافقة لرسم المصحف العثماني وكذلك موافقة للغة
+
+63
+00:05:17,310 --> 00:05:22,010
+العربية فضم الثلاث قراءات أو ثلاث أئمة إلى 
+
+64
+00:05:22,010 --> 00:05:27,310
+القراءات السبعة فصار عشر قراءات و أسألنا في كتاب
+
+65
+00:05:27,310 --> 00:05:33,530
+سماه النشر في القراءات العشر بعد فترة من الزمان جاء 
+
+66
+00:05:33,530 --> 00:05:38,990
+أحمد بن محمد المشهور بالبنة و ألف كتاب اتحاف و ضياء 
+
+67
+00:05:38,990 --> 00:05:43,350
+البشر في القراءات الأربعة عشر لكنه وجد أن هناك 
+
+68
+00:05:43,350 --> 00:05:47,490
+أربع قراءات هذه القراءات الأربعة ليست متواترة
+
+69
+00:05:47,490 --> 00:05:52,130
+ولكنها قراءات صحيحة فألف هذا كتاب اتحاف وضياء
+
+70
+00:05:52,130 --> 00:05:56,570
+البشر في القراءات الأربعة عشر إذا عندنا يا أخوات
+
+71
+00:05:56,570 --> 00:06:02,490
+كم قراءة متواترة عشر قراءات عشر قراءات بعشر أئمة
+
+72
+00:06:02,490 --> 00:06:07,250
+عشر قراءات متواترة موجودة في كتابه أو كتاب النشر في
+
+73
+00:06:07,250 --> 00:06:11,790
+القراءات العشر ومن هنا يعني أصبح عندنا عشر قراءات 
+
+74
+00:06:11,790 --> 00:06:16,690
+ولكن في عندنا قراءات صحيحة اللي هي القراءات الأربع
+
+75
+00:06:16,690 --> 00:06:22,010
+الأخرى التي بعد العشر اللي هي في كتاب اتحاف وضياء
+
+76
+00:06:22,010 --> 00:06:24,830
+البشر في القراءات الأربعة عشر هذه القراءات يا 
+
+77
+00:06:24,830 --> 00:06:29,760
+أخوات قراءات إيش اسمها؟ صحيحة صحيحة تفسيريا من فسر 
+
+78
+00:06:29,760 --> 00:06:36,240
+القرآن مثال ذلك نحن نقرأ في سورة الكهف وكان ورائهم
+
+79
+00:06:36,240 --> 00:06:42,780
+ملك يأخذ كل سفينة غصبا في قراءة أخرى صحيحة ولكنها
+
+80
+00:06:42,780 --> 00:06:48,840
+ليست متواترة وكان أمامهم ملك يأخذ كل سفينة صالحة 
+
+81
+00:06:48,840 --> 00:06:52,760
+غصبا إذا لابد أن تكون السفينة صالحة حتى يأخذها
+
+82
+00:06:52,760 --> 00:06:58,690
+الملك والملك كان ورائهم ولا أمامهم كان أمامهم، إذا 
+
+83
+00:06:58,690 --> 00:07:03,290
+كلمة أمامهم تفسر كلمة ورائهم على أساس أن كلمة
+
+84
+00:07:03,290 --> 00:07:07,270
+ورائهم من الكلمات المتضادة التي تعني الوراء 
+
+85
+00:07:07,270 --> 00:07:13,270
+والأمام، إذا هذه القراءة وكان أمامهم تفسر كلمة 
+
+86
+00:07:13,270 --> 00:07:19,270
+ورائهم أن الملك الظالم كان أين؟ في الأمام كان
+
+87
+00:07:19,270 --> 00:07:24,030
+الملك الظالم يأخذ كل سفينة صالحة غصبا فهذه 
+
+88
+00:07:24,030 --> 00:07:28,610
+القراءات تسمى قراءات تفسيرية نستفيد منها ونفسر أن
+
+89
+00:07:28,610 --> 00:07:32,430
+الملك الظالم لم يكن يأخذ أي سفينة وإنما كان يأخذ
+
+90
+00:07:32,430 --> 00:07:39,270
+السفينة الصالحة غصبا عن أهلها لذلك لما الخضر خرق
+
+91
+00:07:39,270 --> 00:07:43,640
+السفينة كان لمصلحة من؟ لمصلحة المساكين أصحاب
+
+92
+00:07:43,640 --> 00:07:46,840
+السفينة لأن أصحاب السفينة ممكن أن يصلحوا هذا 
+
+93
+00:07:46,840 --> 00:07:50,980
+الفساد البسيط فيها أفضل من أن يأخذها الملك كلها
+
+94
+00:07:50,980 --> 00:07:55,820
+ويكونوا ظالمين طيب، نقطة ثانية يا أخوات، وهي أسباب 
+
+95
+00:07:55,820 --> 00:08:00,180
+انتشار بعض القراءات السبع في الأمصار نحن نقول إن
+
+96
+00:08:00,180 --> 00:08:05,300
+في عندنا عشر قراءات متواترة لا يصح لنا أن نفاضل
+
+97
+00:08:05,300 --> 00:08:11,070
+بينها كيف يعني لا يصح لنا أن نفاضل بين هذه القراءات؟
+
+98
+00:08:11,070 --> 00:08:16,550
+ماذا رأيكم يا أخوات؟ في عندنا قراءات حفص عن عاصم، 
+
+99
+00:08:16,550 --> 00:08:20,150
+قراءة ورش عن نافع، قراءة الدوري عن أبي عمر، قراءة 
+
+100
+00:08:20,150 --> 00:08:26,050
+القالون عن نافع، يعني قراءات متعددة، لا يصح لنا أن
+
+101
+00:08:26,050 --> 00:08:29,470
+نفاضل بين القراءات، يعني لا يصح لنا أن نقول قراءة 
+
+102
+00:08:29,470 --> 00:08:34,650
+حفص عن عاصم أفضل من قراءة ورش عن نافع، لماذا؟ ليش 
+
+103
+00:08:34,650 --> 00:08:41,130
+يا أخوات؟ لأنها كلها قرآن و كلها قراءات متواترة
+
+104
+00:08:41,130 --> 00:08:46,630
+وصحيحة كما أن قراءة حفص عن عاصم متواترة وصحيحة
+
+105
+00:08:46,630 --> 00:08:50,390
+و موافقة لرسم المصحف وموافقة للغة العربية كذلك 
+
+106
+00:08:50,390 --> 00:08:54,550
+قراءة ورش عن نافع أيضا نفس الشروط فلا يصح أن أقول 
+
+107
+00:08:54,550 --> 00:08:59,170
+قراءتي أفضل من قراءته لأنها قراءات كلها متواترة
+
+108
+00:08:59,170 --> 00:09:04,550
+فنحن نأخذها لكن نريد أن نعرف أن هناك قراءات اشتهرت
+
+109
+00:09:04,550 --> 00:09:09,750
+في الأمصار مثلا بلاد الشام ومصر والجزيرة العربية 
+
+110
+00:09:09,750 --> 00:09:17,130
+وكذلك العراق وشرق آسيا وتركيا كلها تقرأ بقراءة
+
+111
+00:09:17,130 --> 00:09:21,750
+حفص عن عاصم بينما بلاد المغرب العربي تقرأ بقراءة
+
+112
+00:09:21,750 --> 00:09:28,660
+من؟ ورش عن نافع في أفريقيا و السودان و البلدان 
+
+113
+00:09:28,660 --> 00:09:32,900
+الأفريقية تقرأ بقراءة الدوري عن أبي عمر البصري
+
+114
+00:09:32,900 --> 00:09:39,300
+اشتهرت ما هي أسباب انتشار هذه القراءات في الأمصار؟ 
+
+115
+00:09:39,300 --> 00:09:44,770
+ماذا رأيكم؟ من يجيب؟ لماذا قراءتنا احنا حفظها نصر 
+
+116
+00:09:44,770 --> 00:09:47,850
+انتشرت هنا؟ لماذا قراءات أخرى انتشرت في أمصار
+
+117
+00:09:47,850 --> 00:09:52,710
+متعددة و أصبح لها تلاميذ وقراء ورواد؟ ليش؟ تفضلي
+
+118
+00:09:52,710 --> 00:09:56,990
+أولا لما أمر أصحاب النفوذ وأصحاب السلطان المقرئين
+
+119
+00:09:56,990 --> 00:09:59,910
+و المدنيين أن يلتزموا هذه القراءة أمام الناس في
+
+120
+00:09:59,910 --> 00:10:02,850
+القاعدة القراءة يعني في عندنا أمرين الأمر الأول أن
+
+121
+00:10:02,850 --> 00:10:08,030
+أصحاب النفوذ و السلطان كانوا يشجعوا ويأمرون الناس
+
+122
+00:10:08,030 --> 00:10:12,700
+بأن يقرؤوا أن يقرؤوا تلاميذهم بهذه القراءة يعني عندنا
+
+123
+00:10:12,700 --> 00:10:17,680
+مثلا السلطان أو الملك كان من أراد أن يتوظف في
+
+124
+00:10:17,680 --> 00:10:21,220
+دايرة الأوقاف لابد أن يكون عارف بقراءة كذا وكذا 
+
+125
+00:10:21,220 --> 00:10:25,440
+قراءة حفص عن عاصم مثلا المدرس الذي يريد أن يدرس
+
+126
+00:10:25,440 --> 00:10:29,710
+أحكام التجويد لابد أن يدرس بقراءة حفص عن عاصم ومن
+
+127
+00:10:29,710 --> 00:10:33,790
+أراد أن يتوظف وظيفة رسمية بدي يكون حافظ قراءة حافظ
+
+128
+00:10:33,790 --> 00:10:37,810
+عن عاصم وبالتالي اشتهرت هذه القراءة أول شيء أصحاب 
+
+129
+00:10:37,810 --> 00:10:41,530
+النفوذ و السلطان كانوا يشجعوا هذه القراءة و يأمرون
+
+130
+00:10:41,530 --> 00:10:45,610
+الناس بأن يقرأوا بها عشان هي اشتهرت السبب الثاني 
+
+131
+00:10:45,610 --> 00:10:49,110
+يا أخوات تحسين بعض العلماء و الشيوخ و المقرئين 
+
+132
+00:10:49,110 --> 00:10:52,170
+لقراءة معينة و اشتهروا بها وجعلهم يقبلوا أحسن كذلك 
+
+133
+00:10:52,170 --> 00:10:57,810
+يا أخوات يعني بعض العلماء والمقرئين والمشايخ كانو
+
+134
+00:10:57,810 --> 00:11:01,450
+يستحسنونها للقراءة يعني يستمتعوا بقراءة كذا، 
+
+135
+00:11:01,450 --> 00:11:04,490
+بقراءة حافظ عن العاصم أو ورش عن النافع استحسنوها 
+
+136
+00:11:04,490 --> 00:11:10,100
+و أحبوها فكان يقرأ الناس بهذه القراءة إذا أسباب
+
+137
+00:11:10,100 --> 00:11:14,640
+انتشار قراءات معينة أو بعض القراءات السبعة في بعض
+
+138
+00:11:14,640 --> 00:11:18,780
+الأمصار السببين أولا أصحاب السلطان و النفوذ كانوا 
+
+139
+00:11:18,780 --> 00:11:22,600
+يأمرون الناس بأن يقرأوا بها ويشجعون الناس على
+
+140
+00:11:22,600 --> 00:11:26,420
+القراءة بها الأمر الثاني أن العلماء والقراء 
+
+141
+00:11:26,420 --> 00:11:30,740
+والمشايخ كانوا يعني يقرؤوا الناس ويقرؤوا تلميذهم
+
+142
+00:11:30,740 --> 00:11:36,650
+بهذه القراءة طيب، لو نظرنا نحن الآن، ما هي القراءات
+
+143
+00:11:36,650 --> 00:11:41,290
+التي يقرأ بها الآن في هذا العصر، في بلاد الإسلام؟
+
+144
+00:11:41,290 --> 00:11:46,070
+في عدة قراءات، هل تقرأ بقراءة مثلًا ابن عامر؟ ولا
+
+145
+00:11:46,070 --> 00:11:51,770
+قراءة حمزة زيات؟ ولا قراءة كذا من القراء الثانين؟
+
+146
+00:11:51,770 --> 00:11:57,170
+لأ، عندنا قراء معينين يقرؤوا باسمهم، ما هي 
+
+147
+00:11:57,170 --> 00:12:02,530
+القراءات التي اشتهرت في الأمصار الإسلامية الآن؟ من
+
+148
+00:12:02,530 --> 00:12:08,390
+يجيب؟ فضليه قراءة قالون عن ورش عن الإمام نافع
+
+149
+00:12:08,390 --> 00:12:11,650
+وانتشرت كلمة من العربي ممتاز، إذن في عندنا قراءة
+
+150
+00:12:11,650 --> 00:12:17,570
+ورش عن نافع وقراءة قالون عن نافع أين اشتهرت هذه
+
+151
+00:12:17,570 --> 00:12:22,770
+القراءة؟ في المغرب العربي، يعني في ليبيا، في تونس،
+
+152
+00:12:22,770 --> 00:12:26,430
+في المغرب، في الجزائر، في موريتانيا، يقرأ بهذه
+
+153
+00:12:26,430 --> 00:12:32,270
+القراءة وهو معروف لدى الجميع وقراءة أخرى فضّالي؟
+
+154
+00:12:32,270 --> 00:12:35,990
+أقرأ برواية حفص بن عاصم في بلاد الشام ممتاز قراءة
+
+155
+00:12:35,990 --> 00:12:41,470
+ورش حفص عن عاصم ابن أبي النجود يقرأ في بلادنا بلاد
+
+156
+00:12:41,470 --> 00:12:45,650
+الشام نحن الآن نقرأ بقراءة حفص عن عاصم إذا فتحنا
+
+157
+00:12:45,650 --> 00:12:51,390
+المصحف نجد على جلدة المصحف قرآن كريم برواية حفص عن
+
+158
+00:12:51,390 --> 00:12:57,330
+عاصم  ولنا مصحف .. مصحف بنفس الرسم بقرا .. برواية
+
+159
+00:12:57,330 --> 00:13:00,910
+حفص عن عاصم، في عندنا كذلك مطبوع مصحف آخر بس
+
+160
+00:13:00,910 --> 00:13:05,670
+موجود في المغرب العربي بقراءة ورش عن نافع أو قالون
+
+161
+00:13:05,670 --> 00:13:11,490
+عن نافع طيب في قراءة أخرى كمان؟ تفضل أخرى قراءة
+
+162
+00:13:11,490 --> 00:13:14,750
+برواية الدوري عن أبي عمر البصري التي انتشرت في
+
+163
+00:13:14,750 --> 00:13:20,070
+السودان وصحيح في قراءة مشهورة بالسودان وكذلك في
+
+164
+00:13:20,070 --> 00:13:27,630
+بلاد أفريقيا والصومال ونيجيريا يقرأ فيها بقراءة
+
+165
+00:13:27,630 --> 00:13:31,670
+الدوري .. بقراءة الدوري عن أبي عمر البصري الدوري
+
+166
+00:13:31,670 --> 00:13:35,850
+عن أبي عمر البصري يقرأ بهذه القراءة وهذه القراءات
+
+167
+00:13:35,850 --> 00:13:40,330
+المشهورة في هذه البلدان إذن القراءات المشهورة التي
+
+168
+00:13:40,330 --> 00:13:45,470
+يعمل بها وهناك مصاحف على .. حسب هذه القراءة أول
+
+169
+00:13:45,470 --> 00:13:49,550
+شيء قراءة عندنا قراءة حفص عن عاصم ابن أبي النجود
+
+170
+00:13:49,550 --> 00:13:54,790
+أي واحد اثنين قراءة ورش عن نافع يقرأ بها في بلاد
+
+171
+00:13:54,790 --> 00:13:59,050
+المغرب العربي ثلاث ثلاثة قراءة قالون عن نافع أيضًا في بلاد
+
+172
+00:13:59,050 --> 00:14:03,930
+المغرب العربي أربع الدوري عن أبي عمر البصري يقرأ
+
+173
+00:14:03,930 --> 00:14:08,890
+بها في بلاد أفريقيا، الصومال، نيجيريا، السودان
+
+174
+00:14:08,890 --> 00:14:13,150
+يقرأ بهذه القراءات ومشهورة أما بالنسبة لباقي
+
+175
+00:14:13,150 --> 00:14:17,310
+القراءات مثل قراءة حمزة الزيات وابن عمر والكسائي
+
+176
+00:14:17,310 --> 00:14:23,130
+وغيرهم فهي قراءة نسميها تراثية بس موجودة في الكتب
+
+177
+00:14:23,640 --> 00:14:29,040
+تُدرس ولكنها ليس لها بلدان مشهورة فيها وليس بها
+
+178
+00:14:29,040 --> 00:14:34,380
+قراء يقرؤون الناس بها ولكنها قراءة متواترة لو أي
+
+179
+00:14:34,380 --> 00:14:37,760
+واحد من المسلمين أراد أن يقرأ بأي قراءة من
+
+180
+00:14:37,760 --> 00:14:41,550
+القراءات المتواترة العشرة يصح له ذلك ولا لا؟ نعم
+
+181
+00:14:41,550 --> 00:14:46,250
+يصح يعني يجوز للقارئ أن يقرأ بقراءة حمزة،
+
+182
+00:14:46,250 --> 00:14:49,750
+بقراءة الكسائي، بقراءة ابن عامر، بقراءة .. بأي
+
+183
+00:14:49,750 --> 00:14:54,190
+قراءة من القراءات العشرة يقرأ بها ويتعبد الله بها
+
+184
+00:14:54,190 --> 00:14:58,160
+ويكون إمامًا .. إمامًا بها لكن لابد أن يعلم الناس لو
+
+185
+00:14:58,160 --> 00:15:02,500
+كان إمامًا ويريد أن يقرأ أمام الناس بقراءة غير
+
+186
+00:15:02,500 --> 00:15:07,100
+القراءة المشهورة عندنا لابد أن يقول للناس يعني
+
+187
+00:15:07,100 --> 00:15:11,460
+سأقرأ عليكم بقراءة ورش عن نافع وهذا الذي يحصل في
+
+188
+00:15:11,460 --> 00:15:16,420
+بلادنا نجد أن هناك بعض المقرئين الذين يتعلموا ولهم
+
+189
+00:15:16,420 --> 00:15:22,050
+سند بقراءة ورش عن نافع أو غيرها يقول للناس خاصة في
+
+190
+00:15:22,050 --> 00:15:26,110
+صلاة الترويح لأننا نصلي جزء من القرآن سنقرأ اليوم
+
+191
+00:15:26,110 --> 00:15:30,630
+بقراءة ورش عن نافع أو بقراءة فلان عن فلان ويستمر
+
+192
+00:15:30,630 --> 00:15:35,630
+لأنه لو قرأ بقراءة أخرى غير القراءة المعهودة عند
+
+193
+00:15:35,630 --> 00:15:40,130
+الناس سيخلطون على الناس وسيكون لبسًا عند الناس
+
+194
+00:15:40,130 --> 00:15:44,450
+يعني لو قال .. احنا نعرف قراءة حفص عن عاصم نقول
+
+195
+00:15:44,450 --> 00:15:50,950
+مالك يوم الدين لو جاء قارئ وقرأ بدون أن يعلم الناس
+
+196
+00:15:50,950 --> 00:15:55,330
+بأنني سوف أقرأ بقراءة ورش عن نافع وقال مالك يوم
+
+197
+00:15:55,330 --> 00:16:01,110
+الدين لقال الناس يعني هذا خطأ الإمام يعني أخطأ، هي
+
+198
+00:16:01,110 --> 00:16:05,740
+أصلًا مالك يوم الدين، وهكذا، لابد أن يعلم الناس ولكن
+
+199
+00:16:05,740 --> 00:16:10,040
+في مقام التعليم يجوز طبعًا لأهل العلم المتخصصين
+
+200
+00:16:10,040 --> 00:16:14,580
+بهذا المجال أن يقرأوا بالقراءات العشرة لأن هذه
+
+201
+00:16:14,580 --> 00:16:19,400
+القراءات العشرة هي قراءات يعني تسمى تراثية أما
+
+202
+00:16:19,400 --> 00:16:22,800
+القراءات المشهورة والمعهودة فهي قراءة القراءات
+
+203
+00:16:22,800 --> 00:16:28,040
+التي ذكرناها سابقًا ننتقل لنقطة أخرى وهي ما هي
+
+204
+00:16:28,040 --> 00:16:32,480
+أسباب انتشار قراءة حفص عن عاصم في بلاد المشرق
+
+205
+00:16:32,480 --> 00:16:37,280
+الإسلامي يعني في بلاد الشام والعراق ومصر والجزيرة
+
+206
+00:16:37,280 --> 00:16:43,970
+العربية والشرق الآسيوي نفس الأسباب السابقة لكن سنقول
+
+207
+00:16:43,970 --> 00:16:47,630
+ماذا؟ الذي هو أن السلاطين العثمانيين في الدولة
+
+208
+00:16:47,630 --> 00:16:51,790
+العثمانية الإسلامية أو الدولة التركية كانوا يعني
+
+209
+00:16:51,790 --> 00:16:55,990
+يشجعوا هذه القراءة ويأمروا الناس بهذه القراءة
+
+210
+00:16:55,990 --> 00:17:00,530
+ويوظفوا الأئمة والمقرئين الذين عندهم علم بهذه
+
+211
+00:17:00,530 --> 00:17:04,030
+القراءة فاشتُهرت هذه القراءة وهي قراءة حفص عن عاصم
+
+212
+00:17:04,030 --> 00:17:09,330
+إذن السلاطين العثمانيين أو الحكام العثمانيين كان
+
+213
+00:17:09,330 --> 00:17:13,750
+لهم أثر كبير في انتشار قراءة حفص عن عاصم في بلاد
+
+214
+00:17:13,750 --> 00:17:18,590
+المشرق الإسلامي ما هو السبب الثاني؟ اه فضليه في
+
+215
+00:17:18,590 --> 00:17:22,310
+اعتمادها في مجالس التعليم ودور التدريس فكانوا
+
+216
+00:17:22,310 --> 00:17:27,460
+يعملوها في التدريس صحيح أيضًا الذي هو العلماء و شيوخ
+
+217
+00:17:27,460 --> 00:17:31,880
+والمقرئين اعتمدوا هذه القراءة في التعليم فكانت دور
+
+218
+00:17:31,880 --> 00:17:36,920
+الكتاب والمدارس والجامعات تحفظ الناس بهذه القراءة
+
+219
+00:17:36,920 --> 00:17:41,860
+وتعلمهم بهذه القراءة طيب ننتقل لسؤال آخر هل
+
+220
+00:17:41,860 --> 00:17:45,500
+المصاحف العثمانية الآن مشتملة يا أخواتي على الأحرف
+
+221
+00:17:45,500 --> 00:17:52,100
+السبعة؟ نحن الآن نقول بأن عثمان بن عفان نسخ
+
+222
+00:17:52,100 --> 00:17:57,170
+المصاحف نسخ المصاحف على حرف واحد وهو حرف قريش و
+
+223
+00:17:57,170 --> 00:18:02,050
+وزّع هذه المصاحف إلى الأنصار هل المصحف العثماني
+
+224
+00:18:02,050 --> 00:18:08,090
+الذي رسمه عثمان بطريقة معينة وهو بدون نقاط وبدون
+
+225
+00:18:08,090 --> 00:18:13,130
+تشكيل رسمه رسمًا بحيث يحتمل أو يشهد اختلاف في
+
+226
+00:18:13,130 --> 00:18:17,490
+القراءات الأخرى هل هذا الرسم العثماني أو المصاحف
+
+227
+00:18:17,490 --> 00:18:21,090
+العثمانية يعني تحتمل أو مشتمل على الأحرف السبعة
+
+228
+00:18:21,090 --> 00:18:26,000
+ولا غير مشتملة؟ يعني هل المصحف العثماني يشتمل على
+
+229
+00:18:26,000 --> 00:18:34,280
+الأحرف السبعة؟ ممتاز
+
+230
+00:18:34,280 --> 00:18:39,140
+فلنقل يا أخوات أن المصحف العثماني رسمه عثمان
+
+231
+00:18:39,140 --> 00:18:45,000
+بن عفان بصورة محددة بدون نقاط وبدون تشكيل بحيث
+
+232
+00:18:45,000 --> 00:18:49,340
+يحتمل أوجه الاختلاف في القراءات الأخرى مثال ذلك
+
+233
+00:18:49,340 --> 00:18:56,540
+كلمة مالك مالك تُكتب عندنا رسمًا مالك مالك
+
+234
+00:18:56,540 --> 00:19:01,080
+ويوضع بعد الميم ألف صغيرة من أراد أن يقراها بقراءة
+
+235
+00:19:01,080 --> 00:19:05,980
+حفص عن عاصم قرأها مالك يوم الدين ومن أراد أن
+
+236
+00:19:05,980 --> 00:19:09,660
+يقراها بقراءة ورش عن نافع قرأها مالك يوم الدين
+
+237
+00:19:09,660 --> 00:19:15,830
+وكذلك سائر الكلمات التي فيها خلاف رسمة .. أو الصلاة
+
+238
+00:19:15,830 --> 00:19:20,330
+.. الصلوات .. الذكاء .. الذكوات يعني رسمة رسمة
+
+239
+00:19:20,330 --> 00:19:24,370
+بحيث تحتمل أو جهود اختلاف في القراءات الأخرى أو في
+
+240
+00:19:24,370 --> 00:19:29,690
+الأحرف الأخرى ننتقل لسؤال آخر ما هي صلة القراءات
+
+241
+00:19:29,690 --> 00:19:35,730
+بالأحرف السبعة؟ هل الأحرف السبعة نفسها القراءات
+
+242
+00:19:35,730 --> 00:19:41,970
+السبعة ولا العشرة؟ ولا تختلف؟ ما رأيكم؟ في عندنا
+
+243
+00:19:41,970 --> 00:19:46,030
+أحرف سبعة القرآن نزل على سبعة أحرف كما علمنا النبي
+
+244
+00:19:46,030 --> 00:19:50,630
+عليه الصلاة والسلام ولكن الآن لا يوجد أحرف سبعة
+
+245
+00:19:50,630 --> 00:19:54,910
+وإنما يوجد عندنا قراءات سبعة ولا عشرة أو أربع
+
+246
+00:19:54,910 --> 00:19:57,770
+عشر في عندنا تَحَفَّظَ رأي البشر في القراءات العشرة
+
+247
+00:19:57,770 --> 00:20:02,370
+ما هي صلة الأحرف السبعة أو القراءات بالأحرف
+
+248
+00:20:02,370 --> 00:20:07,180
+السبعة؟ هل هناك صلة؟ فضل أختي هي جزء من الأحرف
+
+249
+00:20:07,180 --> 00:20:11,660
+السبعة صحيح القراءات يا أخوات هي بقايا الأحرف
+
+250
+00:20:11,660 --> 00:20:16,840
+السبعة وجزء من الأحرف السبعة التي وصلتنا متواترة
+
+251
+00:20:16,840 --> 00:20:20,680
+يعني مثلًا عاصم ابن أبي النجوم الذي تلقى العلم عن
+
+252
+00:20:20,680 --> 00:20:26,000
+أبي عبد الرحمن السلمي اشتهر بأنه كان يعني يأخذ غير
+
+253
+00:20:26,000 --> 00:20:29,880
+ما هو موجود في المصحف العثماني بعض الروايات الموجودة
+
+254
+00:20:29,880 --> 00:20:34,080
+التي أخذها عن الرسول عليه الصلاة والسلام يقول فلان
+
+255
+00:20:34,080 --> 00:20:38,640
+يقرأ بصيغة كذا واشتهرت عليه هذه بعض الكلمات ولذلك
+
+256
+00:20:38,640 --> 00:20:44,470
+سميت قراءة ورش أي قراءة حفص عن عاصم .. قراءة عاصم
+
+257
+00:20:44,470 --> 00:20:49,950
+ابن أبي النجود إذن القراءات السبعة ليست هي الأحرف
+
+258
+00:20:49,950 --> 00:20:55,530
+السبعة وإنما هي بقايا الأحرف السبعة لأن عثمان بن
+
+259
+00:20:55,530 --> 00:21:00,170
+عفان عندما جمع المصحف جمعه على حرف واحد وهو أي
+
+260
+00:21:00,170 --> 00:21:08,240
+حرف؟ حرف قريش لماذا حرف قريش بالذات؟ لأنه ..هو لغة
+
+261
+00:21:08,240 --> 00:21:11,980
+الرسول عليه الصلاة والسلام ونزل القرآن بداية على
+
+262
+00:21:11,980 --> 00:21:14,940
+حرف قريش وبعد ذلك في المدينة نزل القرآن على سبعة
+
+263
+00:21:14,940 --> 00:21:19,600
+أحرف ولأنه أبلغ الحروف وأفصح الحروف وأشهر
+
+264
+00:21:19,600 --> 00:21:22,800
+الحروف لأنه كانت القبائل العربية تأتي من كل
+
+265
+00:21:22,800 --> 00:21:27,240
+الجزيرة العربية إلى مكة المكرمة للحج فكانت اللغة
+
+266
+00:21:27,240 --> 00:21:31,160
+المشهورة والمعروفة والمعهودة وأبلغ اللغات لغة
+
+267
+00:21:31,160 --> 00:21:35,340
+قريش ولذلك عثمان بن عفان لما جمع المصحف جمعه على
+
+268
+00:21:35,340 --> 00:21:41,810
+حرف حرف واحد وهو حرف قريش ولكنّه رسم رسمًا بدون نقاط
+
+269
+00:21:41,810 --> 00:21:45,850
+وبدون تشكيل ليحتمل أوجه الاختلاف في القراءات
+
+270
+00:21:45,850 --> 00:21:50,170
+الأخرى فكان ذلك هناك علاقة ما بعد ذلك اشتهرت
+
+271
+00:21:50,170 --> 00:21:56,970
+القراءات وصارت القراءات هي جزء من الأحرف السبعة
+
+272
+00:21:56,970 --> 00:22:02,190
+عندنا يا أخوات أيضًا بعض التعريفات التي لابد أن
+
+273
+00:22:02,190 --> 00:22:07,640
+نتعرف عليها كمقدمة في علم القراءات أول شيء القراءات
+
+274
+00:22:07,640 --> 00:22:13,580
+لغة جمع قراءة وهي مأخوذة القراءة .. مأخوذة إذ هي
+
+275
+00:22:13,580 --> 00:22:18,560
+مصدر .. مأخوذة من القرء بمعنى الجمع والضم أو
+
+276
+00:22:18,560 --> 00:22:25,480
+مأخوذة من تلا .. تلا يعني من قرأ بمعنى تلاوة كأن
+
+277
+00:22:25,480 --> 00:22:30,840
+الذي يقرأ القراءة أو الكلمات هو يجمع ويضم الحروف
+
+278
+00:22:30,840 --> 00:22:35,760
+بعضها إلى بعض ويقرأها إذن كلمة القراءات من حيث
+
+279
+00:22:35,760 --> 00:22:43,320
+اللغة القراءات جمع قراءة والقراءة من الفعل قرأ
+
+280
+00:22:43,320 --> 00:22:50,990
+وقرأ من القرء بمعنى الضم والجمع في اللغة أو من قرأ
+
+281
+00:22:50,990 --> 00:22:56,410
+بمعنى تلا وكأن الذي يقرأ يجمع ويضم الحروف مع بعضها
+
+282
+00:22:56,410 --> 00:23:02,250
+البعض فتصبح الحروف كلمة وتصبح الكلمات جمل ويتلوها
+
+283
+00:23:02,250 --> 00:23:06,810
+أو يقراها فتصبح قراءة هذه من حيث اللغة وهناك علاقة
+
+284
+00:23:06,810 --> 00:23:11,250
+ما بين التعريف اللغوي والتعريف الاصطلاحي لمعنى
+
+285
+00:23:11,250 --> 00:23:15,630
+قراءة أما القراءة من حيث الإصطلاح يعني لو واحد قرأ
+
+286
+00:23:15,630 --> 00:23:21,230
+كتاب أو قرأ قرآن فهو معناه في التعريف الإصطلاحي ضم 
+
+287
+00:23:21,230 --> 00:23:25,610
+الحروف والكلمات بعضها إلى بعض في القراءة أو
+
+288
+00:23:25,610 --> 00:23:30,430
+الترتيب يعني أوراد أن يقرأ كتاب عبارة عن الحروف
+
+289
+00:23:30,430 --> 00:23:34,650
+نضمها فتصبح الحروف كلمات والكلمات نجمعها ونضمها
+
+290
+00:23:34,650 --> 00:23:38,790
+فتصبح الكلمات جمل ويقرأها سواء يريد أن يقرأ من
+
+291
+00:23:38,790 --> 00:23:44,570
+كتاب ولا يريد أن يقرأ قراءة من المصحف فالقراءة من
+
+292
+00:23:44,570 --> 00:23:49,070
+حيث الإصطلاح كقراءة ليست قراءة قرآنية إنما قراءة
+
+293
+00:23:49,070 --> 00:23:53,550
+من كتاب هي ضم الحروف والكلمات بعضها إلى بعض في
+
+294
+00:23:53,550 --> 00:23:58,750
+القراءة أو الترتيب أما بالنسبة لعلم القراءات الذي
+
+295
+00:23:58,750 --> 00:24:04,490
+نحن بصدد الحديث عنه علم القراءات يا أخوات هو علم
+
+296
+00:24:04,490 --> 00:24:09,330
+بكيفية أداء كلمات القرآن واختلافها معزوة لناقلها
+
+297
+00:24:09,330 --> 00:24:14,810
+علم بكيفية أداء الكلمات القرآنية واختلافها معزوة
+
+298
+00:24:14,810 --> 00:24:20,720
+لناقله من ناقله؟اللي هو الإمام يعني هو علم بكيفية
+
+299
+00:24:20,720 --> 00:24:24,280
+أداء الكلمات القرآنية يعني كيف تؤدى هذه الكلمة؟
+
+300
+00:24:24,280 --> 00:24:28,780
+الكلمة نفسها ولكن ممكن أن تؤدى بالترقيق ولا
+
+301
+00:24:28,780 --> 00:24:33,480
+بالتفخيم بالإمالة ولا بغير الإمالة؟ بالهمز ولا
+
+302
+00:24:33,480 --> 00:24:37,480
+بالتسهيل؟ يعني مثلا نقول المؤمنون نحن نقرأها 
+
+303
+00:24:37,480 --> 00:24:41,320
+بالهمز المؤمنون هناك قراءة المؤمنون مثلا قراءات
+
+304
+00:24:41,320 --> 00:24:46,960
+أخرى يعني علم بكيفية أداء هذه الكلمات القرآنية
+
+305
+00:24:46,960 --> 00:24:52,400
+واختلافها يعني تختلف قراءة حفص عن عاصم..عن..
+
+306
+00:24:52,400 --> 00:24:56,980
+حفص عن عاصم عن ورش عن نافع عن قراءة كده وكده معزوة
+
+307
+00:24:56,980 --> 00:25:01,460
+لناقله يعني لابد أن نذكر الإمام نقول والله قراءة
+
+308
+00:25:01,460 --> 00:25:05,880
+ورش عن نافع اللي هو الإمام نافع كده وكده قراءة حفص
+
+309
+00:25:05,880 --> 00:25:11,120
+عن عاصم كده وكده إذا من يقول لي أو يعرف لي علم
+
+310
+00:25:11,120 --> 00:25:21,000
+القراءات من يعرف لي علم القراءات؟ اتفضلي أختي صحيح
+
+311
+00:25:21,000 --> 00:25:25,340
+علم بكيفية أداء الكلمات القرآنية واختلافها مع ذو
+
+312
+00:25:25,340 --> 00:25:30,920
+اللي ناقله وناقله المفوض به هو الإمام طيب في عند
+
+313
+00:25:30,920 --> 00:25:36,300
+أخوات قراءات متواترة وقراءات صحيحة وقراءات يعني
+
+314
+00:25:36,300 --> 00:25:43,190
+غير صحيحة القراءة المتواترة ما هو تعريف القراءة
+
+315
+00:25:43,190 --> 00:25:47,990
+المتواترة؟ طبعا العلماء وضعوا لها شروط وعرفوها
+
+316
+00:25:47,990 --> 00:25:52,150
+وشروط القراءة المتواترة موجودة في التعريف نفسه من
+
+317
+00:25:52,150 --> 00:25:55,430
+يُعرف لي القراءة المتواترة؟ اتفضلي أختي
+
+318
+00:25:59,400 --> 00:26:03,700
+مثالًا ولا تقريرًا؟ أحسن تقرأ وتقرأ نقلها إذا كل
+
+319
+00:26:03,700 --> 00:26:07,240
+قراءة وافقة اللغة العربية لابد أن تكون القراءة
+
+320
+00:26:07,240 --> 00:26:10,900
+موافقة للغة العربية كيف يمكن أن تكون موافقة للغة
+
+321
+00:26:10,900 --> 00:26:15,180
+العربية؟ يعني الفاعل بيكون مرفوع لو جاءت قراءة
+
+322
+00:26:15,180 --> 00:26:20,190
+وقرأت جاء المؤمنين نقول خطأ خطأ لأن القرآن نزل
+
+323
+00:26:20,190 --> 00:26:25,070
+بلسان عربي مبين لو قلنا جاء المؤمنين هي لا جاء
+
+324
+00:26:25,070 --> 00:26:30,090
+المؤمنون مثلا وجاء رجل ما بنفع نقول وجاء رجلا
+
+325
+00:26:30,090 --> 00:26:34,650
+فإذا كانت القراءة مخالفة للغة العربية فهي شاذة لا
+
+326
+00:26:34,650 --> 00:26:39,470
+نقبلها إذا لابد أن يكون الفعل مرفوع والمفعول به
+
+327
+00:26:39,470 --> 00:26:45,150
+منصوب سواء كمنصوب بالياء ولا منصوب بالفتحة وهكذا
+
+328
+00:26:45,150 --> 00:26:50,230
+لابد أن يكون موافق للغة العربية كل قراءة أو هي كل
+
+329
+00:26:50,230 --> 00:26:55,150
+قراءة وافقت للغة العربية مطلقا ووافقت رسم المصحف
+
+330
+00:26:55,150 --> 00:27:00,810
+العثماني ولو تقديرا وتواتر نقلها فهي قراءة متواترة
+
+331
+00:27:00,810 --> 00:27:05,930
+ومن هنا..من هذا التعريف نستطيع أن نذكر الشروط
+
+332
+00:27:05,930 --> 00:27:10,550
+التي وضعها العلماء لتكون القراءة قراءة متواترة من
+
+333
+00:27:10,550 --> 00:27:14,830
+يذكر لي استنبط الشروط من هذا التعريف اتفضلي
+
+334
+00:27:30,600 --> 00:27:34,640
+النقطة الأولى الشرط الأول أن تكون موافقة للغة
+
+335
+00:27:34,640 --> 00:27:39,550
+العربية الشرط الثاني لابد أن تكون موافق للرسم
+
+336
+00:27:39,550 --> 00:27:43,750
+العثماني ولو تقديرا، كيف؟ ولو تقديرا، يعني في
+
+337
+00:27:43,750 --> 00:27:49,230
+عندنا قراءة جنات تجري تحتها الأنهار، قراءة أخرى
+
+338
+00:27:49,230 --> 00:27:54,270
+جنات تجري من تحتها الأنهار يعني بزيادة حرف من
+
+339
+00:27:54,270 --> 00:27:59,930
+تقديرا إن من تحتها يعني من بعضها وليست كل الجنات
+
+340
+00:27:59,930 --> 00:28:03,390
+فوجود حرف من صحيح أنه زيادة على الرسم العثماني
+
+341
+00:28:03,390 --> 00:28:08,930
+لكنه بيفهمنا المقصود إن جنات تجري تحتها الأنهار
+
+342
+00:28:09,640 --> 00:28:14,220
+قراءة أخرى جنات تجري من تحتها الأنهار يعني من
+
+343
+00:28:14,220 --> 00:28:18,660
+بعضها لأنها ليست كل الجنات تجري من تحتها الأنهار
+
+344
+00:28:18,660 --> 00:28:24,180
+وإنما الجنة مواطن جنات يعني تجري من تحتها الأنهار
+
+345
+00:28:24,180 --> 00:28:27,700
+يعني من بين قصونها ولا في جنات أحيانا لا تجري من
+
+346
+00:28:27,700 --> 00:28:31,940
+تحتها الأنهار بينتقد إنسان مؤمن في أهل الجنة ما بين
+
+347
+00:28:31,940 --> 00:28:36,020
+هذه الجنة وهذه الجنة والله أعلم إذا أنها وافقة
+
+348
+00:28:36,020 --> 00:28:40,380
+رسم المصحف ولو تقديرا وتواترا نقلها ما معناه يا
+
+349
+00:28:40,380 --> 00:28:45,760
+أخوات وتواترا نقلها بالإذن لو سمحتوا ما معناه
+
+350
+00:28:45,760 --> 00:28:54,620
+المتواترة أخذته في الحديث هو ما رواه جمع عن جمع في
+
+351
+00:28:54,620 --> 00:28:58,720
+كل طبقة من طبقات السند تحيي للعالم تواطؤهم على
+
+352
+00:28:58,720 --> 00:29:02,280
+الكذب يعني النبي عليه الصلاة والسلام نزل عليه
+
+353
+00:29:02,280 --> 00:29:07,100
+جبريل بالقرآن فجبريل علمه للصحابة والصحابة عدد
+
+354
+00:29:07,100 --> 00:29:12,520
+كبير جدا يعني يقول بعض العلماء 120 ألف صحابي يعني
+
+355
+00:29:12,520 --> 00:29:18,240
+حافظوا القرآن بمجموعهم متواترا والصحابة علموه
+
+356
+00:29:18,240 --> 00:29:22,760
+للتابعين والتابعون علموه لأتباع التابعين وهكذا حتى
+
+357
+00:29:22,760 --> 00:29:29,000
+وصل إلينا القراءة المتواترة هو يعني ما رواه جمع عن
+
+358
+00:29:29,000 --> 00:29:33,320
+جمع في كل طبقة من طبقات السند تحيي للعادة تواطؤهم
+
+359
+00:29:33,320 --> 00:29:36,640
+على الكذب إذا لابد أن تكون القراءة وصلت لعاصم
+
+360
+00:29:36,640 --> 00:29:40,240
+متواترة ليست من واحد من خمسين ستين أو مائة واحد
+
+361
+00:29:40,240 --> 00:29:45,140
+وصلت له فبتكون القراءة متواترة إذا تعريف القراءة
+
+362
+00:29:45,140 --> 00:29:49,810
+المتواترة هو كل قراءة وافقة اللغة العربية مطلقا
+
+363
+00:29:49,810 --> 00:29:55,150
+ووافقة رسم المصحف العثماني ولو تقديرا وتواتر نقلها
+
+364
+00:29:55,150 --> 00:29:59,790
+فهي قراءة متواترة ويلحق بالقراءات المتواترة
+
+365
+00:29:59,790 --> 00:30:05,230
+السبعة هناك كمان ثلاث قراءات كما ذكرها ابن الجزري
+
+366
+00:30:05,230 --> 00:30:11,050
+وهي في كتابه النشر في القراءات العشر يجمع ثلاث
+
+367
+00:30:11,050 --> 00:30:14,250
+قراءات يعني بقى سبعة زائد ثلاث عشر قراءة متواترة
+
+368
+00:30:14,250 --> 00:30:20,010
+والعشر قراءات أخوات المتواترة يقرأوا بها ونتعبد
+
+369
+00:30:20,010 --> 00:30:26,090
+الله بها ونصل بها فهي كلها قرآن وكلها يعني يجوز
+
+370
+00:30:26,090 --> 00:30:30,100
+لنا أن نتعبد الله بها كما جاء في كتاب النشر في
+
+371
+00:30:30,100 --> 00:30:33,800
+القراءات العشر أما القراءات الصحيحة الأربعة لا
+
+372
+00:30:33,800 --> 00:30:37,980
+نصلي بها وإنما نأخذ بها من باب التفسير والفهم
+
+373
+00:30:37,980 --> 00:30:42,460
+لآيات القرآن الكلمة كذلك من ضمن التعريفات التي سوف
+
+374
+00:30:42,460 --> 00:30:46,980
+ندرسها في هذه المقدمة عن علم القراءات تعريف
+
+375
+00:30:46,980 --> 00:30:52,160
+القراءة في قراءة اسمها قراءة قرآنية ما هو تعريف
+
+376
+00:30:52,160 --> 00:30:57,210
+القراءة القرآنية؟ ما رأيكم؟ اتفضلي هو الاختيار
+
+377
+00:30:57,210 --> 00:31:00,150
+المنسوب لأحد الأئمة العشرة في كيفية قراءة لفظ
+
+378
+00:31:00,150 --> 00:31:02,630
+القرآن مما رواه بسنده عن النبي صلى الله عليه وسلم
+
+379
+00:31:02,630 --> 00:31:06,990
+أحسن هو الاختيار المنسوب لأحد الأئمة العشرة يعني
+
+380
+00:31:06,990 --> 00:31:11,790
+نقول مثلا عاصم ابن ابن نجود، نافع، حمزة الزيات،
+
+381
+00:31:11,790 --> 00:31:15,590
+ابن عامر، الكسائي من هؤلاء القراءات يبقى اختيار
+
+382
+00:31:15,590 --> 00:31:20,510
+منسوب..يعني نصف هذا الاختيار في قراءة اللفظة
+
+383
+00:31:20,510 --> 00:31:25,450
+الفلانية للإمام فلان الفلان في كيفية قراءة لفظة
+
+384
+00:31:25,530 --> 00:31:30,030
+قرآنية مما رواه بسنده عن النبي عليه الصلاة
+
+385
+00:31:30,030 --> 00:31:36,010
+والسلام. لو سألنا حفص ابن سليمان عن من أخذ القراءة
+
+386
+00:31:36,010 --> 00:31:43,460
+عن عاصم عاصم ابن ابن نجود عاما أخذ القراءة عن أبي
+
+387
+00:31:43,460 --> 00:31:47,760
+عبد الرحمن السلمي وهو المقرئ الذي أرسله عثمان ابن
+
+388
+00:31:47,760 --> 00:31:52,880
+عَفّان ليقرأ الناس القرآن في الكوفة أو العراق أبو
+
+389
+00:31:52,880 --> 00:31:57,480
+عبد الرحمن السلمي أخذ القراءة عنه علي ابن أبي طالب
+
+390
+00:31:57,480 --> 00:32:01,720
+وعن غيره وعلي ابن أبي طالب أخذها عن النبي عليه
+
+391
+00:32:01,720 --> 00:32:07,040
+الصلاة والسلام فالقراءة متواصلة بالسند إذا القراءة
+
+392
+00:32:07,040 --> 00:32:11,740
+هي اختيار المنسوب لأحد الأئمة العشرة في كيفية
+
+393
+00:32:11,740 --> 00:32:17,100
+قراءة لفظ قرآني مما رواه بسنده عن النبي صلى الله
+
+394
+00:32:17,100 --> 00:32:22,460
+عليه وسلم فيقالوا قراءة نافع أو قراءة حمزة أو
+
+395
+00:32:22,460 --> 00:32:26,780
+قراءة عاصم أو قراءة الكسائي أو قراءة حمزة الزيات
+
+396
+00:32:26,780 --> 00:32:30,880
+أو قراءة ابن عمر أو قراءة جعفر أو أي قراءة من هذه
+
+397
+00:32:30,880 --> 00:32:35,720
+القراءات التي هي قراءات متواترة عن النبي صلى الله
+
+398
+00:32:35,720 --> 00:32:40,740
+عليه وسلم طيب هذه عرفنا القراءة والاختيار المنصوب
+
+399
+00:32:40,740 --> 00:32:44,920
+لأحد الأئمة في كذلك يا أخوات في عندنا رواية إحنا
+
+400
+00:32:44,920 --> 00:32:52,280
+نقول رواية حفص عن عاصم إذا الراوي هيكون إيش؟ حفص
+
+401
+00:32:52,280 --> 00:32:59,040
+بيروي عن القارئ عاصم برواية حفص عن عاصم فالرواية
+
+402
+00:32:59,040 --> 00:33:04,240
+هي كل ما نسب لأحد الرواية عن أحد الأئمة العشرة
+
+403
+00:33:04,240 --> 00:33:08,700
+فالإمام من الأئمة العشرة..أحد الأئمة العشرة وهو
+
+404
+00:33:08,700 --> 00:33:14,840
+عندنا عاصم، من الذي روى عن عاصم؟ حفص، إذا حفص بن
+
+405
+00:33:14,840 --> 00:33:20,600
+سليمان هو الراوي عن عاصم وكذلك شعبان بن عياش أيضا
+
+406
+00:33:20,600 --> 00:33:25,520
+روى عن عاصم، يسمى راوي، فالرواية هي كل ما نسب
+
+407
+00:33:25,520 --> 00:33:30,270
+لأحد من أحد الأئمة من أحد الرواية عن أحد الأئمة
+
+408
+00:33:30,270 --> 00:33:36,790
+العشرة فيقال رواية حفص عن عاصم رواية شعبة عن عاصم
+
+409
+00:33:36,790 --> 00:33:42,690
+رواية ورش عن نافع رواية القزاعي عن ابن كثير وهكذا
+
+410
+00:33:42,690 --> 00:33:48,370
+تسمى رواية طيب هذه الرواية اللي هو حفص عن عاصم
+
+411
+00:33:48,370 --> 00:33:56,030
+ورش عن نافع من الذي نقلها إلينا؟ من اللي نقلها
+
+412
+00:33:56,030 --> 00:34:02,090
+إلينا واحد سواء كان إنسان ولا حتى على بعد منها
+
+413
+00:34:02,090 --> 00:34:07,590
+كتاب مثلا من طريق عبيد بن الصباح من طريق عبيد بن 
+
+414
+00:34:07,590 --> 00:34:12,470
+الصباح هذا أحد الأئمة أو أحد العلماء نقلنا عن حفص
+
+415
+00:34:12,470 --> 00:34:18,090
+بن سليمان وحفص بن سلم من نقل عن عاصم ابن ابن نجود
+
+416
+00:34:18,090 --> 00:34:24,190
+هذه تسمى طريق، إذا الطريق هو كل ما نسبه لمن نقل عن
+
+417
+00:34:24,190 --> 00:34:29,410
+الراوي وإنسان فلان يبقى اللي بنقل عن الراوي اسمه من
+
+418
+00:34:29,410 --> 00:34:36,430
+طريق فلان الراوي بينقل عن الإمام ويسمى راوي الراوي
+
+419
+00:34:36,430 --> 00:34:42,200
+.. القراء الإمام بيقرأ والقارئ يسمى إمام إذا قرأنا
+
+420
+00:34:42,200 --> 00:34:49,140
+نحن عن طريق وصلت إلينا من طريق عبيد بن الصباح عن
+
+421
+00:34:49,140 --> 00:34:56,020
+الراوي حفص بن سليمان عن الإمام اللي هو عاصم بن أبي
+
+422
+00:34:56,020 --> 00:34:59,880
+النجود وعاصم أخذ عن أبي عبد الرحمن السلمي وأبو عبد
+
+423
+00:34:59,880 --> 00:35:04,400
+الرحمن السلمي أخذ عن علي بن أبي طالب وعلي أخذ عن
+
+424
+00:35:04,400 --> 00:35:09,120
+الرسول صلى الله عليه وسلم. التعريف يا أخوات يقول هو
+
+425
+00:35:09,120 --> 00:35:15,100
+كل ما نسبه لمن نقل عن الراوي وإن سفل ما معناه سفل؟ 
+
+426
+00:35:15,100 --> 00:35:20,700
+يعني وإن بعدت المسافة ما بين الراوي والطريق اللي 
+
+427
+00:35:20,700 --> 00:35:25,220
+نقلها إلينا مثلًا من طريق الشاطبية يعني بعد عدة 
+
+428
+00:35:25,220 --> 00:35:32,860
+رواة حدثناهم حدثنا السند ونقلت الشاطبية عن حفص بن 
+
+429
+00:35:32,860 --> 00:35:38,500
+سليمان أو طيبة النشر عن حفص ابن سليمان لكن طيبة
+
+430
+00:35:38,500 --> 00:35:44,920
+ده كتاب. كتاب. أما ما بين طيبة النشر أو الشاطبية
+
+431
+00:35:44,920 --> 00:35:49,860
+ما بينها وبين حفص بن سليمان كام رواي؟ محدثين عدة 
+
+432
+00:35:49,860 --> 00:35:55,700
+رواة. لكننا مع هذا بنقول من طريق الشاطبية عن حفص 
+
+433
+00:35:55,700 --> 00:35:59,970
+بن سليمان عن عاصم بن أبي نجود أو من طريق طيبة
+
+434
+00:35:59,970 --> 00:36:04,750
+النشر عن حفص بن سليمان عن عاصم بن أبي نجود. هذه
+
+435
+00:36:04,750 --> 00:36:09,330
+تسمى يا أخوات طريق. إذا .. إذا الطريق هو كل .. كل 
+
+436
+00:36:09,330 --> 00:36:13,130
+ما نسبه لمن نقل عن الراوي اللي نقل عن الراوي
+
+437
+00:36:13,130 --> 00:36:16,810
+بنسميه طريق. الراوي اللي بينقل عن الإمام بنسميه 
+
+438
+00:36:16,810 --> 00:36:20,230
+رواية. الإمام اللي بينقل عن الرسول عليه الصلاة 
+
+439
+00:36:20,230 --> 00:36:24,530
+والسلام بالسند بنسميه إمام أو بنسميه إيش؟ بنسميه
+
+440
+00:36:24,530 --> 00:36:30,240
+قراءة. ومن هنا في عنا قراء الآن نريد أن نأخذ
+
+441
+00:36:30,240 --> 00:36:37,280
+القراءات العشرة الروابط بس نذكر ذكر طبعًا كل إمام 
+
+442
+00:36:37,280 --> 00:36:43,020
+من الأئمة تتلمذ على يديه ممكن أن نقول آلاف من طلبة
+
+443
+00:36:43,020 --> 00:36:49,940
+العلم لكن الكتاب ذكر هنا لكل إمام راوين. مثلًا عاصم
+
+444
+00:36:49,940 --> 00:36:56,500
+بن أبي نجود وهو شيخ القراء بالكوفة. روى عنه آلاف من 
+
+445
+00:36:56,500 --> 00:37:02,260
+العلماء .. من التلاميذ لكننا اخترنا أشهر وأفضل
+
+446
+00:37:02,260 --> 00:37:07,000
+اثنين لأن هو اللي هم .. اللي هم اشتهروا وطال
+
+447
+00:37:07,000 --> 00:37:12,640
+عمرهم حتى بلغ أحدهم 98 سنة وهو يدرس الناس. أيه
+
+448
+00:37:12,640 --> 00:37:16,320
+يعني اشتهرت هذه القراءة؟ اللي هو حفص بن سليمان
+
+449
+00:37:16,320 --> 00:37:22,100
+اللي توفي وعمره تسعين سنة وكذلك شعبة ابن عياش
+
+450
+00:37:22,100 --> 00:37:25,900
+اللي توفي وعمره ثمانية وتسعين سنة يعني خمسين،
+
+451
+00:37:25,900 --> 00:37:29,540
+ستين ولا سبعين أو ثمانين سنة وهو قاعد بيدرس يعني 
+
+452
+00:37:29,540 --> 00:37:37,590
+هذا شعبة ابن عياش مثلًا بيدرس الأب أو الابن أو
+
+453
+00:37:37,590 --> 00:37:43,350
+للتلميذ وابنه وابن ابنه وابن ابن ابنه يعني 80 
+
+454
+00:37:43,350 --> 00:37:49,670
+سنة هو قاعد بيدرس. أكيد هذه السلسلة تركت له تلميذ
+
+455
+00:37:49,670 --> 00:37:54,170
+بالآلاف وبالتالي عاصم بن أبي نجود وهو إمامنا 
+
+456
+00:37:54,170 --> 00:37:58,730
+إمام القراءة التي ندرس بها له تلميذان حفص بن
+
+457
+00:37:58,730 --> 00:38:03,330
+سليمان وشعبة بن عياش. كذلك نافع .. طبعًا هذه
+
+458
+00:38:03,330 --> 00:38:07,910
+المطلوبة منكم. أما باقي القراءات نريد أن نذكرها ذكرًا
+
+459
+00:38:07,910 --> 00:38:12,070
+ويعني هناك مادة تسمى القراءات تدرسوها بالتفصيل
+
+460
+00:38:12,070 --> 00:38:18,650
+عندنا مثلًا الإمام نافع بن عبد الرحمن المدني له
+
+461
+00:38:18,650 --> 00:38:23,910
+تلميذان هما قالون وورش وهما اللتان ندرسها أو نقرأها
+
+462
+00:38:23,910 --> 00:38:29,850
+ورش عن نافع أو قالون عن نافع. ابن كثير له تلميذان 
+
+463
+00:38:29,850 --> 00:38:36,450
+أيضًا اللي هو البزي وقنبل. أبو عمر البصري له تلميذان 
+
+464
+00:38:36,450 --> 00:38:42,890
+الدوري والسوسي. ابن عمر الشامي له تلميذان هشام وابن
+
+465
+00:38:42,890 --> 00:38:46,970
+ذاكوان. حمزة الزيات .. الإمام حمزة الزيات أيضًا
+
+466
+00:38:46,970 --> 00:38:54,610
+نختار له تلميذان خلف وخالد .. خلف وخالد أقصد .. 
+
+467
+00:38:54,610 --> 00:38:58,870
+الإمام الكسائي له تلميذان أبو الحارث الليث
+
+468
+00:38:58,870 --> 00:39:04,470
+البغدادي والدوري. الإمام أبو .. طبعًا الدوري يتكرر مع
+
+469
+00:39:04,470 --> 00:39:08,410
+أبي عمر البصري بيكون أخذ من هذا وأخذ من هذا يعني
+
+470
+00:39:08,410 --> 00:39:12,290
+لأن العلماء كانوا يعني يأخذون من بعضهم البعض فيكون 
+
+471
+00:39:12,290 --> 00:39:17,290
+له شيخان اللي هو أبو عمر البصري بالإضافة لأبي جعفر
+
+472
+00:39:17,290 --> 00:39:22,490
+الكسائي. أبو جعفر المدني أيضًا له تلميذان ابن وردان
+
+473
+00:39:22,490 --> 00:39:27,130
+وابن جماز. الإمام يعقوب الحضرمي له تلميذان رويس
+
+474
+00:39:27,130 --> 00:39:32,510
+وروح. الإمام خلف البزار أيضًا له تلميذان اللي هو
+
+475
+00:39:32,510 --> 00:39:37,450
+إسحاق المروزي وإدريس. هؤلاء الأئمة العشرة وبعد 
+
+476
+00:39:37,450 --> 00:39:43,510
+ذلك الأربعة تعد قراءتهم .. صحيح. لا نحفظ بس روايتنا
+
+477
+00:39:43,510 --> 00:39:49,440
+حفص عن عاصم. أما أولئك بس للعلم للدراسة. أخذنا يا 
+
+478
+00:39:49,440 --> 00:39:54,320
+أخوات بالنسبة للقراءة المتواترة لها أركان اللي هي
+
+479
+00:39:54,320 --> 00:39:58,340
+الشروط. شروط القراءة المتواترة مثل ما ذكرناها في
+
+480
+00:39:58,340 --> 00:40:02,900
+التعريف. أول شيء لابد أن تكون موافقة للرسم للغة
+
+481
+00:40:02,900 --> 00:40:08,560
+العربية. اثنين موافقة للرسم العثماني. ثلاثة صحة
+
+482
+00:40:08,560 --> 00:40:11,060
+السند وتواتر الرواية. يعني تكون الرواية متواترة
+
+483
+00:40:11,060 --> 00:40:15,600
+والسند صحيح. موافقة لرسم المصحف وموافقة للغة
+
+484
+00:40:15,600 --> 00:40:22,130
+العربية. آخر شيء ندرسه نحن وهو مهم جدًا، ما هو سند
+
+485
+00:40:22,130 --> 00:40:27,350
+رواية حفص عن عاصم؟ من يدخل ليه الآن؟ ما هو سند 
+
+486
+00:40:27,350 --> 00:40:34,590
+رواية حفص عن عاصم؟ ذكرته عدة مرات؟ أه، مين عارف؟
+
+487
+00:40:34,590 --> 00:40:41,070
+جادينكم، فضلي. حفص ابن سليمان 
+
+488
+00:40:41,070 --> 00:40:43,830
+أخذ سماعا عن عاصم بن أبي نجود.
+
+489
+00:40:46,990 --> 00:40:50,810
+أحسن. مين كمان من يذكر لي السند؟ طبعًا هذا يا إخوان
+
+490
+00:40:50,810 --> 00:40:54,930
+يجي دائمًا يأتي لأن هو مهم وهو الفاصلة اللي عندنا
+
+491
+00:40:54,930 --> 00:40:58,290
+اذكري السند رواية .. الرواية التي يقرا بها أهل
+
+492
+00:40:58,290 --> 00:41:02,850
+الشام أو اذكري السند رواية حفص عن عاصم هتقولي يعني
+
+493
+00:41:02,850 --> 00:41:07,830
+حفص بن سليمان أخذ سماعا عن عاصم بن أبي النجود.
+
+494
+00:41:07,830 --> 00:41:12,270
+عاصم أخذ عن أبي عبد الرحمن السلمي سماعا أيضًا لأنه
+
+495
+00:41:12,270 --> 00:41:16,200
+كان تلميذه. أبو عبد الرحمن السلمي أخذ عن علي بن أبي
+
+496
+00:41:16,200 --> 00:41:19,620
+طالب. وعلي بن أبي طالب أخذه عن رسول الله صلى الله
+
+497
+00:41:19,620 --> 00:41:23,580
+عليه وسلم. وهذه الرواية وصلتنا من طريق الشاطبية
+
+498
+00:41:23,580 --> 00:41:28,900
+عن عبيد بن الصباح عن حفص بن سليمان إلى نهاية السند.
+
+499
+00:41:29,090 --> 00:41:32,790
+أنهينا الآن يا أخوات مقدمة في القراءات وإن شاء
+
+500
+00:41:32,790 --> 00:41:36,370
+الله في المحاضرة القادمة سوف نأخذ مقدمة في علم
+
+501
+00:41:36,370 --> 00:41:39,910
+التجويد لأنه بداية علم التجويد. أخذنا العديد من 
+
+502
+00:41:39,910 --> 00:41:43,130
+المقدمات نكتفي بهذا القدر وبارك الله فيكم. السلام
+
+503
+00:41:43,130 --> 00:41:44,450
+عليكم ورحمة الله وبركاته
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..525b3f7befa1933ab3e358e0408196f2df2d25f0
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HZevRtBeibw_postprocess.srt
@@ -0,0 +1,2012 @@
+1
+00:00:11,460 --> 00:00:15,180
+بسم الله الرحمن الرحيم الحمد لله و صلاة و سلام على
+
+2
+00:00:15,180 --> 00:00:19,060
+رسول الله و على آله و صحبه وسلم موضوعنا اليوم يا
+
+3
+00:00:19,060 --> 00:00:23,340
+أخوات عن مقدمة في علم التجويض أو مقدمة في علم
+
+4
+00:00:23,340 --> 00:00:27,910
+القراءاتوحتى نستطيع أن ندرس هذا الموضوع دراسة
+
+5
+00:00:27,910 --> 00:00:33,730
+رسمية لابد أن نرجع قليلا إلى الوراق أخدنا سابقا أن
+
+6
+00:00:33,730 --> 00:00:39,290
+عثمان بن عفان وجد أو أن الأمة قد اختلفت في الأحرف
+
+7
+00:00:39,290 --> 00:00:44,810
+السبعة عندما تجمع المسلمون في موطن من مواطن الجهاد
+
+8
+00:00:44,810 --> 00:00:50,140
+وهو أذربيجان و أرمينياكان المسلمون مع بعضهم البعض
+
+9
+00:00:50,140 --> 00:00:55,780
+في ما التابعين قد اختلفوا على الأحرف السبعة حتى
+
+10
+00:00:55,780 --> 00:01:00,320
+كاد بعضهم أن يكفر بعضا لذلك حذيفة بن اليمن حضر هذا
+
+11
+00:01:00,320 --> 00:01:05,000
+المشهد فاستاذن من أمير الجند ورجع إلى الخليفة
+
+12
+00:01:05,000 --> 00:01:09,620
+عثمان بن عفان وقال له اذكوا الأمة قبل أن يختلفوا
+
+13
+00:01:09,620 --> 00:01:14,540
+على كتاب ربهم كما اختلف اليهود والنصارى وفهمه
+
+14
+00:01:14,540 --> 00:01:17,740
+الموضوع أن المسلمين يختلفون على الأحرف السبعة
+
+15
+00:01:18,920 --> 00:01:22,900
+فعثمان بن عفان جمع الصحابة و قال لهم اجتمعوا يا
+
+16
+00:01:22,900 --> 00:01:27,420
+أصحاب محمد أنتم هاهنا تختلفون و أنتم في مدينة رسول
+
+17
+00:01:27,420 --> 00:01:31,840
+الله صلى الله عليه وسلم فمن نقى عنكم كان أشد
+
+18
+00:01:31,840 --> 00:01:36,310
+اختلافا اجتمعوا يا أصحاب محمد حتى نجد حلافلمّا
+
+19
+00:01:36,310 --> 00:01:40,110
+اجتمعوا واتشاوروا قالوا لابد أن نجمع القرآن على
+
+20
+00:01:40,110 --> 00:01:44,210
+حرف واحد وهو حرف قريش فجمعوا القرآن على حرف قريش
+
+21
+00:01:44,210 --> 00:01:49,910
+وهو أبلغ الحروف وافصحها ونسخوا نسخة يعني على حرف
+
+22
+00:01:49,910 --> 00:01:54,970
+واحد عثمان بن عفان طلب المصحف من سيدة حفصة أم
+
+23
+00:01:54,970 --> 00:01:59,230
+المؤمنين رضي الله عنها ونسخ المصحف على حرف واحد
+
+24
+00:01:59,230 --> 00:02:04,430
+وجعل أربع من الصحابة الكرام الشبابهم الذين ينسخونا
+
+25
+00:02:04,430 --> 00:02:09,370
+هذه النسخ و هم زيدو بن ثابت و عبدالله بن الزغير و
+
+26
+00:02:09,370 --> 00:02:13,410
+سعيد بن العاص و أبو عبدالرحمن او عبدالرحمن بن حارث
+
+27
+00:02:13,410 --> 00:02:20,310
+بن هشام نسخوا المصحف على حرف واحد ثم نسخوه على سبع
+
+28
+00:02:20,310 --> 00:02:26,130
+نسخ و قيلة خمسة نسخو أرسلوها إلى البلدان و الأنصار
+
+29
+00:02:26,130 --> 00:02:32,130
+المجاورة فكان يرسل مع كل مصحف أحد المقرئين أرسل
+
+30
+00:02:32,130 --> 00:02:36,350
+عبد الله بن السائق المفزومي إلى مكة مع مصحف إلى
+
+31
+00:02:36,350 --> 00:02:41,230
+مكة و أرسل مصحف كذلك إلى الكوفة و أرسل معه مقرء و
+
+32
+00:02:41,230 --> 00:02:44,670
+هو أبو عبد الرحمن السلمي و أرسل مصحفا أخر إلى
+
+33
+00:02:44,670 --> 00:02:49,640
+البصرةو أرسل معه عامد ابن قيس و أرسل مصحفا أخر إلى
+
+34
+00:02:49,640 --> 00:02:53,820
+الشام و أرسل معه المغيرة ابن أبي شهاب المخزومي و
+
+35
+00:02:53,820 --> 00:02:57,620
+أرسل مصحفا خامسا إلى المدينة المنورة و أرسل معه
+
+36
+00:02:57,620 --> 00:03:02,880
+زيد ابن ثابت و قيل أنه أرسل كمان مصحفين مصحف إلى
+
+37
+00:03:02,880 --> 00:03:07,840
+اليمن و مصحف إلى البحرين المهم أنه مع كل مصحف من
+
+38
+00:03:07,840 --> 00:03:12,820
+المصحف العثمانية التي رسمت و التي نسخت أرسل معه
+
+39
+00:03:12,820 --> 00:03:18,190
+قارئ يقرأ الناسفاشتهر هذا القارئ و تتلمذ عليه آلاف
+
+40
+00:03:18,190 --> 00:03:23,390
+من الطلاب بعض الطلاب أصبحوا مشهورين و علماء من
+
+41
+00:03:23,390 --> 00:03:28,930
+أمثال مثلا عاصم ابن أبي النجود الذي أخذ العلم عن
+
+42
+00:03:28,930 --> 00:03:32,150
+أبي عبد الرحمن السلمي فاشتهرة .. اشتهرة بعض
+
+43
+00:03:32,150 --> 00:03:35,990
+العلماء و بعض القراء فأصبح أولئك القراء يعني
+
+44
+00:03:35,990 --> 00:03:41,930
+مشهورين و من هنا ظهر علم القراءاتإذن متى ظهر علم
+
+45
+00:03:41,930 --> 00:03:47,730
+القراءات بعد أن أرسله عثمان بن عفان المصاحف و أرسل
+
+46
+00:03:47,730 --> 00:03:53,730
+مع كل مصحف مقرء و .. و تعلم على يد هؤلاء المقرئين
+
+47
+00:03:53,730 --> 00:03:58,590
+علماء فاضل و أبدعوا في هذا العلم و اشتهروا ..
+
+48
+00:03:58,590 --> 00:04:02,550
+اشتهروا بعضهم بطريقة معينة من أمثال عاصم بن أبن
+
+49
+00:04:02,550 --> 00:04:06,930
+نجود الذي تلقى العلم عن أبي عبد الرحمن السلمي وهو
+
+50
+00:04:06,930 --> 00:04:12,570
+سند رواية حفص عن عاصمفنحن نأخذ روايتنا حفص ابن
+
+51
+00:04:12,570 --> 00:04:17,230
+سليمان عن عاصم ابن أبي النجود عن أبي عبد الرحمن
+
+52
+00:04:17,230 --> 00:04:21,310
+السلمي عن علي ابن أبي طالب عن رسول الله صلى الله
+
+53
+00:04:21,310 --> 00:04:26,370
+عليه وسلم اشتهر هؤلاء الأئمة المقرئين فجاء ابن
+
+54
+00:04:26,370 --> 00:04:33,090
+مجاهد وجمع أشهر سبع قراءات أو أشهر سبع أئمة من
+
+55
+00:04:33,090 --> 00:04:38,600
+ضمنهم قراءة عاصم ابن أبي النجودوألف كتاب سماه
+
+56
+00:04:38,600 --> 00:04:44,040
+السبعة في القراءات لإبن مجاهد لذلك لو سألنا سؤال
+
+57
+00:04:44,040 --> 00:04:50,420
+من هو أول من سبع السبعة يعني أول من جبع سبع قراء
+
+58
+00:04:50,420 --> 00:04:55,360
+أو سبع قراءات في كتاب واحد اللي هو هيكون إبن مجاهد
+
+59
+00:04:55,360 --> 00:05:00,870
+هو أول من سبع السبعةثم جاء يعني ابن الجزري بعد
+
+60
+00:05:00,870 --> 00:05:06,330
+فترة من الزمان فوجد أن هناك كمان ثلاث قراءات لها
+
+61
+00:05:06,330 --> 00:05:12,190
+شروط متواترة يعني صحة سندها وحديث ورواية متواترة
+
+62
+00:05:12,190 --> 00:05:17,310
+وموافقة لرسم المصحف العثماني وكذلك موافقة للغة
+
+63
+00:05:17,310 --> 00:05:22,010
+العربية فضم الثلاث قراءات أو ثلاث أئمة إلى
+
+64
+00:05:22,010 --> 00:05:27,310
+القراءات السبعة فصار عشر قراءاتوأسألنا في كتاب
+
+65
+00:05:27,310 --> 00:05:33,530
+سماه النشر في القرائات العشربعد فترة من الزمان جاء
+
+66
+00:05:33,530 --> 00:05:38,990
+أحمد ابن محمد المشهور بالبنة وألف كتاب اتحاف وضلاء
+
+67
+00:05:38,990 --> 00:05:43,350
+البشر في القراءات الأربعة عشر لكنه وجد أن هناك
+
+68
+00:05:43,350 --> 00:05:47,490
+أربع قراءات هذه القراءات الأربعة ليست متواترة
+
+69
+00:05:47,490 --> 00:05:52,130
+ولكنها قراءات صحيحة فألف هذا كتاب اتحاف وضلاء
+
+70
+00:05:52,130 --> 00:05:56,570
+البشر في القراءات الأربعة عشر إذا عندنا يا أخوات
+
+71
+00:05:56,570 --> 00:06:02,490
+كام قراءة متواترةعشر قراءات عشر قراءات بعشر أئمة
+
+72
+00:06:02,490 --> 00:06:07,250
+عشر قراءات متواتر موجودة في كتابه أو كتاب النشر في
+
+73
+00:06:07,250 --> 00:06:11,790
+القراءات العشر ومن هنا يعني أصبح عندنا عشر قراءات
+
+74
+00:06:11,790 --> 00:06:16,690
+ولكن في عندنا قراءات صحيحة اللي هي الراء الأربع
+
+75
+00:06:16,690 --> 00:06:22,010
+الأخرى التي بعد العشر اللي هي في كتاب اتحاف وضلاء
+
+76
+00:06:22,010 --> 00:06:24,830
+البشر في القراءات الأربعة عشر هذه القراءات يا
+
+77
+00:06:24,830 --> 00:06:29,760
+أخوات قراءات إيش اسمها؟ صحيحةصحيحة تفسيريا من فسر
+
+78
+00:06:29,760 --> 00:06:36,240
+القرآن مثال ذلك نحن نقرأ في سورة الكهف وكان وراهم
+
+79
+00:06:36,240 --> 00:06:42,780
+ملك يأخذ كل سفينة غصبة في قراء أخرى صحيحة ولكنها
+
+80
+00:06:42,780 --> 00:06:48,840
+ليست متواترة وكان أمامهم ملك يأخذ كل سفينة صالحة
+
+81
+00:06:48,840 --> 00:06:52,760
+غصبة إذا لابد أن تكون السفينة صالحة حتى يأخذها
+
+82
+00:06:52,760 --> 00:06:58,690
+الملك والملك كان وراهم ولا أمامهمكان أمامهم، إذا
+
+83
+00:06:58,690 --> 00:07:03,290
+كلمة أمامهم بتفسر كلمة وراءهم على أساس أن كلمة
+
+84
+00:07:03,290 --> 00:07:07,270
+وراءهم من الكلمات المتضادة التي تعني الوراء
+
+85
+00:07:07,270 --> 00:07:13,270
+والأمام، إذا هذه القراءة وكان أمامهم بتفسر كلمة
+
+86
+00:07:13,270 --> 00:07:19,270
+وراءهم أن الملك الظالم كان أين؟ في الأماموكان
+
+87
+00:07:19,270 --> 00:07:24,030
+الملك الظالم يأخذ كل سفينة صالحة غصبة فهذه
+
+88
+00:07:24,030 --> 00:07:28,610
+القراءات تسمى قراءات تفسيرية نستفيد منها ونفسر أن
+
+89
+00:07:28,610 --> 00:07:32,430
+الملك الظالم لم يكن يأخذ أي سفينة وإنما كان يأخذ
+
+90
+00:07:32,430 --> 00:07:39,270
+السفينة الصالحة غصبا عن أهلها لذلك لما الخضر خرق
+
+91
+00:07:39,270 --> 00:07:43,640
+السفينة كان لمصلحة من؟لمصلحة المساكين أصحاب
+
+92
+00:07:43,640 --> 00:07:46,840
+السفينة لأن أصحاب السفينة ممكن أن يصلحوا هذا
+
+93
+00:07:46,840 --> 00:07:50,980
+الفساد البسيط فيها أفضل من أن يأخذها الملك كلها
+
+94
+00:07:50,980 --> 00:07:55,820
+ويكونوا ظالمين طيب، نقطة ثانية يا أخوات، وهي أسباب
+
+95
+00:07:55,820 --> 00:08:00,180
+انتشار بعض القراءات السابعة في الأنصار نحن نقول إن
+
+96
+00:08:00,180 --> 00:08:05,300
+في عنا عشر قراءات متواترة لا يصح لنا أن نفاضل
+
+97
+00:08:05,300 --> 00:08:11,070
+بينهاكيف يعني لا يصحوا أن نفاضل بين هذه القراءات؟
+
+98
+00:08:11,070 --> 00:08:16,550
+ما رأيكم يا أخوات؟ في عندنا قراءات حفص عن عاصم،
+
+99
+00:08:16,550 --> 00:08:20,150
+قراءة ورش عن نافع، قراءة الدور عن أبي عمر، قراءة
+
+100
+00:08:20,150 --> 00:08:26,050
+القالون عن نافع، يعني قراءات متعددة، لا يصح لنا أن
+
+101
+00:08:26,050 --> 00:08:29,470
+نفاضل بين القراءات، يعني لا يصح لنا أن نقول قراءة
+
+102
+00:08:29,470 --> 00:08:34,650
+حفص عن عاصم أفضل من قراءة ورش عن نافع، لماذا؟ ليش
+
+103
+00:08:34,650 --> 00:08:41,130
+يا أخوات؟لأنها كلها قرآن وكلها قراءات متواترة
+
+104
+00:08:41,130 --> 00:08:46,630
+وصحيحة كما أن قراءة حفظ عن عاصم متواترة وصحيحة
+
+105
+00:08:46,630 --> 00:08:50,390
+وموافقة لرسم المصحف وموافقة لللغة العربية كذلك
+
+106
+00:08:50,390 --> 00:08:54,550
+قراءة ورش عن نافع أيضا نفس الشروط فلا يصح أن أقول
+
+107
+00:08:54,550 --> 00:08:59,170
+قراءتي أفضل من قراءته لأنها قراءات كلها متواترة
+
+108
+00:08:59,170 --> 00:09:04,550
+فنحن ناخدهالكن نريد أن نعرف أن هناك قراءات اشتهرت
+
+109
+00:09:04,550 --> 00:09:09,750
+في الأمصار مثلا بلاد الشام و مصر و الجزيرة العربية
+
+110
+00:09:09,750 --> 00:09:17,130
+و كذلك العراق و شرق آسيا و تركيا كلها تقرأ بقراءة
+
+111
+00:09:17,130 --> 00:09:21,750
+حفص عن عاصم بينما بلاد المغرب العربي تقرأ بقراءة
+
+112
+00:09:21,750 --> 00:09:28,660
+من؟وارشع النافع في أفريقيا و السودان و البلدان
+
+113
+00:09:28,660 --> 00:09:32,900
+الأفريقية تقرأ بقراءة الدوري عن أبي عمر البصري
+
+114
+00:09:32,900 --> 00:09:39,300
+اشتهرت ما هي أسباب انتشار هذه القراءات في الأنصار؟
+
+115
+00:09:39,300 --> 00:09:44,770
+ما رأيكم؟من يجاوب؟ لماذا قراءتنا احنا حفظها نصر
+
+116
+00:09:44,770 --> 00:09:47,850
+انتشرت هنا؟ لماذا قراءات أخرى انتشرت في أمصار
+
+117
+00:09:47,850 --> 00:09:52,710
+متعددة و أصبح لها تلميذ و قراء و رواد؟ ليش؟ تفضلي
+
+118
+00:09:52,710 --> 00:09:56,990
+اولا لما أمر أصحاب النفوذ و أصحاب السلطان المقرئين
+
+119
+00:09:56,990 --> 00:09:59,910
+و المدينين أن يلتزموا هذه القراءة أمام الناس في
+
+120
+00:09:59,910 --> 00:10:02,850
+القاعدة القراءة يعني في عندنا أمرين الأمر الأول أن
+
+121
+00:10:02,850 --> 00:10:08,030
+أصحاب النفوذ و السلطان كانوا يشجعوا و يأمروا الناس
+
+122
+00:10:08,030 --> 00:10:12,700
+بأن يقرؤواأن يقرؤ تلميذهم بهذه القراءة يعني عندنا
+
+123
+00:10:12,700 --> 00:10:17,680
+مثلا السلطان أو الملك كان من أراد أن يتوظف في
+
+124
+00:10:17,680 --> 00:10:21,220
+ذائرة الأوقاف لابد أن يكون عارف لقراية كذا و كذا
+
+125
+00:10:21,220 --> 00:10:25,440
+قراية حفص عن عاصم مثلا المدرس الذي يريد أن يدرس
+
+126
+00:10:25,440 --> 00:10:29,710
+أحكام التجويض لابد أن يدرس بقراية حفص عن عاصمومن
+
+127
+00:10:29,710 --> 00:10:33,790
+أراد أن يتوظف وظيفة رسمية بدي يكون حافظ قراءة حافظ
+
+128
+00:10:33,790 --> 00:10:37,810
+عن عاصم وبالتالي اشتهرت هذه القراءة أول شيء أصحاب
+
+129
+00:10:37,810 --> 00:10:41,530
+النفوذي والسلطان كانوا يشجعوا هذه القراءة ويأمروا
+
+130
+00:10:41,530 --> 00:10:45,610
+الناس بأن يقرأوا بها عشان هي اشتهرت السبب الثاني
+
+131
+00:10:45,610 --> 00:10:49,110
+يا أخوات تحسين بعض العلماء والشيوف والمقرئين
+
+132
+00:10:49,110 --> 00:10:52,170
+لقراءة معينة واشتهروا بيها وجعلهم يقبلوا أحسن كذلك
+
+133
+00:10:52,170 --> 00:10:57,810
+يا أخوات يعني بعض العلماء والمقرئين والمشايخكانوا
+
+134
+00:10:57,810 --> 00:11:01,450
+يستحسنوها للقراءة، يعني يستمتعوا بقراءة كذا،
+
+135
+00:11:01,450 --> 00:11:04,490
+بقراية حافظ على العاصم أو ورشع النافع، استحسنوها
+
+136
+00:11:04,490 --> 00:11:10,100
+وحبوها، فكان يقرؤ الناس بهذه القراءةإذا أسباب
+
+137
+00:11:10,100 --> 00:11:14,640
+انتشار قراءات معينة أو بعض القراءات السبعة في بعض
+
+138
+00:11:14,640 --> 00:11:18,780
+الأمصار السببين أولا أصحاب السلطان والنفوذ كانوا
+
+139
+00:11:18,780 --> 00:11:22,600
+يأمروا الناس بأن يقرأوا بها ويشجعوا الناس على
+
+140
+00:11:22,600 --> 00:11:26,420
+القراءة بها الأمر الثاني أن العلماء والقراء
+
+141
+00:11:26,420 --> 00:11:30,740
+والمشايخ كانوا يعني يقرؤوا الناس ويقرؤوا تلميذهم
+
+142
+00:11:30,740 --> 00:11:36,650
+بهذه القراءةطيب، لو نظرنا نحن الآن، ما هي القراءات
+
+143
+00:11:36,650 --> 00:11:41,290
+التي يقرأ بها الآن في هذا العصر، في بلاد الإسلام؟
+
+144
+00:11:41,290 --> 00:11:46,070
+في عدة قراءات، هل تقرأ بقراءة مثلا ابن عامر؟ ولا
+
+145
+00:11:46,070 --> 00:11:51,770
+قراءة حمزة زيات؟ ولا قراءة كذا من القراء الثانين؟
+
+146
+00:11:51,770 --> 00:11:57,170
+لأ، عندنا قراء معينين يقرأوا باسمهم، ما هي
+
+147
+00:11:57,170 --> 00:12:02,530
+القراءات التي اشتهرت في الأمصار الإسلامية الآن؟من
+
+148
+00:12:02,530 --> 00:12:08,390
+يجيب؟ فضليه قراءة قالون عن ورش عن الإمام نافع
+
+149
+00:12:08,390 --> 00:12:11,650
+وانتشرت كلمة من العربي ممتاز، إذا في عندنا قراءة
+
+150
+00:12:11,650 --> 00:12:17,570
+ورش عن نافع وقراءة قالون عن نافع أين اشتهرت هذه
+
+151
+00:12:17,570 --> 00:12:22,770
+القراءة؟ في المغرب العربي، يعني في ليبيا، في تونس،
+
+152
+00:12:22,770 --> 00:12:26,430
+في المغرب، في الجزائر، في موريتانيا، يقرأ بهذه
+
+153
+00:12:26,430 --> 00:12:32,270
+القراءة وهو معروف لدى الجميع وقراءة أخرىفضّالي؟
+
+154
+00:12:32,270 --> 00:12:35,990
+أقرأ برواية حفص بن عاصم في بلاد الشام ممتاز قراية
+
+155
+00:12:35,990 --> 00:12:41,470
+ورش حفص عن عاصم ابن أبي النجود يقرأ في بلادنا بلاد
+
+156
+00:12:41,470 --> 00:12:45,650
+الشام نحن الآن نقرأ بقراية حفص عن عاصم إذا فتحنا
+
+157
+00:12:45,650 --> 00:12:51,390
+المصحف نجد على جلدة المصحف قرآن كريم برواية حفص عن
+
+158
+00:12:51,390 --> 00:12:57,330
+عاصمولنا مصحف .. مصحف بنفس الرسم بقرا .. برواية
+
+159
+00:12:57,330 --> 00:13:00,910
+حافظ عن عاصم، في عندنا كذلك مطبوع مصحف آخر بس
+
+160
+00:13:00,910 --> 00:13:05,670
+موجود في المغرب العربي بقراءة ورش عن نافع أو قالون
+
+161
+00:13:05,670 --> 00:13:11,490
+عن نافع طيب في قراءة أخرى كمان؟ تفضل أخرىقراءة
+
+162
+00:13:11,490 --> 00:13:14,750
+برواية الدوري عن أبي عمر البصري اللي انتشرت في
+
+163
+00:13:14,750 --> 00:13:20,070
+السودان وصحيح في قراءة مشهورة بالسودان و كذلك في
+
+164
+00:13:20,070 --> 00:13:27,630
+بلاد أفريقيا و الصومال و نيجيريا يقرأ فيها بقراءة
+
+165
+00:13:27,630 --> 00:13:31,670
+الدوري .. بقراءة الدوري عن أبي عمر البصري الدوري
+
+166
+00:13:31,670 --> 00:13:35,850
+عن أبي عمر البصري يقرأ بهذه القراءة و هذه القراءات
+
+167
+00:13:35,850 --> 00:13:40,330
+المشهورة في هذه البلدانإذن القراءات المشهورة التي
+
+168
+00:13:40,330 --> 00:13:45,470
+يعمل بها وهناك مصاحف على .. حسب هذه القراءة أول
+
+169
+00:13:45,470 --> 00:13:49,550
+شيء قراية عندنا قراية حفص عن عاصم ابن أبو النجود
+
+170
+00:13:49,550 --> 00:13:54,790
+أي واحد اتنين قراية ورش عن نافع يقرأ بها في بلاد
+
+171
+00:13:54,790 --> 00:13:59,050
+المغرب العربيتلاتة قالون عن نافع أيضًا في بلاد
+
+172
+00:13:59,050 --> 00:14:03,930
+المغرب العربي أربع الدوري عن أبي عمر البصري يقرأ
+
+173
+00:14:03,930 --> 00:14:08,890
+بها في بلاد أفريقيا، الصومان، نيجيريا، السودان
+
+174
+00:14:08,890 --> 00:14:13,150
+يقرأ بهذه القراءات ومشهورة أما بالنسبة لباقي
+
+175
+00:14:13,150 --> 00:14:17,310
+القراءات مثل قراءة حمزة الزياك وإبن عمر والكسائي
+
+176
+00:14:17,310 --> 00:14:23,130
+وغيرهم فهي قراءة نسميها تراثية بس موجودة في الكتب
+
+177
+00:14:23,640 --> 00:14:29,040
+تدرسوا ولكنها ليس لها بلدان مشهورة فيها وليس بها
+
+178
+00:14:29,040 --> 00:14:34,380
+قراء يقرؤون الناس بها ولكنها قراءة متواترة لو أي
+
+179
+00:14:34,380 --> 00:14:37,760
+واحد من المسلمين أراد أن يقرأ بأي قراءة من
+
+180
+00:14:37,760 --> 00:14:41,550
+القراءات المتواترة العشريصحوا له ذلك ولا لا؟ نعم
+
+181
+00:14:41,550 --> 00:14:46,250
+يصحوا يعني يجوزوا للقارئ أن يقرأ بقراءة حمزة،
+
+182
+00:14:46,250 --> 00:14:49,750
+بقراءة الكسائر، بقراءة ابن العامر، بقراءة .. بأي
+
+183
+00:14:49,750 --> 00:14:54,190
+قراءة من القراءات العشرة يقرأ بها ويتعبد الله بها
+
+184
+00:14:54,190 --> 00:14:58,160
+ويكون إماما .. إماما بهالكنه لابد أن يعلم الناس لو
+
+185
+00:14:58,160 --> 00:15:02,500
+كان إماما ويريد أن يقرأ أمام الناس بقراءة غير
+
+186
+00:15:02,500 --> 00:15:07,100
+القراءة المشهورة عندنا لابد أن يقول للناس يعني
+
+187
+00:15:07,100 --> 00:15:11,460
+سأقرأ عليكم بقراءة ورشع النافع وهذا الذي يحصل في
+
+188
+00:15:11,460 --> 00:15:16,420
+بلادنا نجد أن هناك بعض المقرئين الذين يتعلموا ولهم
+
+189
+00:15:16,420 --> 00:15:22,050
+سند بقراءة ورشع النافع أو غيرهايقول للناس خاصة في
+
+190
+00:15:22,050 --> 00:15:26,110
+صلاة الترويح لأننا نصلي جزء من القرآن سنقرأ اليوم
+
+191
+00:15:26,110 --> 00:15:30,630
+بقراءة ورش عن نافع أو بقراءة فلان عن فلان ويستمر
+
+192
+00:15:30,630 --> 00:15:35,630
+لأنه لو قرأ بقراءة أخرى غير القراءة المعهودة عند
+
+193
+00:15:35,630 --> 00:15:40,130
+الناس سيخلطوا عن الناس وسيكونوا لبسا عند الناس
+
+194
+00:15:40,130 --> 00:15:44,450
+يعني لو قال .. احنا نعرف قراءة حفظ عن عاصم نقول
+
+195
+00:15:44,450 --> 00:15:50,950
+مالك يوم الدينلو جاء قارئ وقرأ بدون أن يعلم الناس
+
+196
+00:15:50,950 --> 00:15:55,330
+بأنني سوف أقرأ بقراءة وارش عن نافع وقال مالك يوم
+
+197
+00:15:55,330 --> 00:16:01,110
+الدين لقال الناس يعني هذا خطأ الإمام يعني أخطأ، هي
+
+198
+00:16:01,110 --> 00:16:05,740
+أصلا مالك يوم الدين، وهكذا، لابد أن يعلم الناسولكن
+
+199
+00:16:05,740 --> 00:16:10,040
+في مقام التعليم يجوز طبعاً للأهل العلم المتخصصين
+
+200
+00:16:10,040 --> 00:16:14,580
+بهذا المجال أن يقرأوا بالقراءات العشرة لأن هذه
+
+201
+00:16:14,580 --> 00:16:19,400
+القراءات العشرة هي قراءات يعني تسمى تراثية أما
+
+202
+00:16:19,400 --> 00:16:22,800
+القراءات المشهورة والمعهودة فهي قراءة القراءات
+
+203
+00:16:22,800 --> 00:16:28,040
+التي ذكرناها سابقاًننتقل لنقطة أخرى وهي ما هي
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+204
+00:16:28,040 --> 00:16:32,480
+أسباب انتشار قراءة حفص عن عاصم في بلاد المشرق
+
+205
+00:16:32,480 --> 00:16:37,280
+الإسلامي يعني في بلاد الشام والعراق ومصر والجزيرة
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+206
+00:16:37,280 --> 00:16:43,970
+العربية والشرق آسيانفس الأسباب السابقة لكن سنقول
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+207
+00:16:43,970 --> 00:16:47,630
+إيش؟ اللي هو أن السلاطين العثمانيين في الدولة
+
+208
+00:16:47,630 --> 00:16:51,790
+العثمانية الإسلامية أو الدولة التركية كانوا يعني
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+209
+00:16:51,790 --> 00:16:55,990
+يشجعوا هذه القراءة ويأمروا الناس بهذه القراءة
+
+210
+00:16:55,990 --> 00:17:00,530
+ويوظفوا الأئمة والمقرئين الذين عندهم علم بهذه
+
+211
+00:17:00,530 --> 00:17:04,030
+القراءة فاشتفرت هذه القراءة وهي قراية حفظ عن عاصمة
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+212
+00:17:04,030 --> 00:17:09,330
+إذا السلاطينالعثمانيين أو الحكام العثمانيين كان
+
+213
+00:17:09,330 --> 00:17:13,750
+لهم أثر كبير في انتشار قراءة حفظ عن عاصم في بلاد
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+214
+00:17:13,750 --> 00:17:18,590
+المشرط الإسلامي ما هو السبب الثاني؟ اه فضليه في
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+215
+00:17:18,590 --> 00:17:22,310
+اعتبادها في مناجة تعليم ودور التدريس فكانوا
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+216
+00:17:22,310 --> 00:17:27,460
+يعملوها في التدريس صحيح أيضا اللي هو العلماءوشيوخ
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+217
+00:17:27,460 --> 00:17:31,880
+والمقرئين اعتمدوا هذه القراءة في التعليم فكانت دور
+
+218
+00:17:31,880 --> 00:17:36,920
+الكتاب والمدارس والجامعات تحفظ الناس بهذه القراءة
+
+219
+00:17:36,920 --> 00:17:41,860
+وتعلمهم بهذه القراءة طيب ننتقل لسؤال آخر هل
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+220
+00:17:41,860 --> 00:17:45,500
+المصاحف العثمانية الآن مشتملة يا أخواتي على الأحرف
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+221
+00:17:45,500 --> 00:17:52,100
+السبعة؟ نحن الآن نقول بأن العثمان بن عفان نسخ
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+222
+00:17:52,100 --> 00:17:57,170
+المصاحفنسخ المصاحف على حرف واحد و هو حرف قريش و
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+223
+00:17:57,170 --> 00:18:02,050
+وزّع هذه المصاحف إلى الأنصار هل المصحف العثماني
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+224
+00:18:02,050 --> 00:18:08,090
+الذي رسمه عثمان بطريقة معينة و هو بدون نقاط و بدون
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+225
+00:18:08,090 --> 00:18:13,130
+تشكيل رسمه رسما بحيث يحتمل أو يشهد اختلاف في
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+226
+00:18:13,130 --> 00:18:17,490
+القراءات الأخرى هل هذا الرسم العثماني أو المصاحف
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+227
+00:18:17,490 --> 00:18:21,090
+العثمانية يعني تحتمل أو مشتمل على الأحرف السبعة
+
+228
+00:18:21,090 --> 00:18:26,000
+ولا غير مشتملة؟يعني هل المصحف العثماني يشتمل على
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+229
+00:18:26,000 --> 00:18:34,280
+الأحرف السابعة؟ أمتاز
+
+230
+00:18:34,280 --> 00:18:39,140
+فخليني أقول يا أخوات أن المصحف العثماني رسمه عثمان
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+231
+00:18:39,140 --> 00:18:45,000
+ابن عفان بصورة محددة بدون نقاط و بدون تشكيل بحيث
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+232
+00:18:45,000 --> 00:18:49,340
+يحتمل أوجه الاختلاف في القراءات الأخرى مثال ذلك
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+233
+00:18:49,340 --> 00:18:56,540
+كلمة مالكيمالكي تُكتب عندنا رسمًا مالكي مالكي
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+234
+00:18:56,540 --> 00:19:01,080
+ويوضع بعد الميم ألف صغيرة من أراد أن يقراها بقراية
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+235
+00:19:01,080 --> 00:19:05,980
+حفص عن عاصم قرأها مالك يوم الدين ومن أراد أن
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+236
+00:19:05,980 --> 00:19:09,660
+يقراها بقراية ورش عن نافع قرأها مالك يوم الدين
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+237
+00:19:09,660 --> 00:19:15,830
+وكذلك سائرالكلمات التي فيها خلاف رسمة .. او الصلاة
+
+238
+00:19:15,830 --> 00:19:20,330
+.. الصلاوات .. الذكاء .. الذكوات يعني رسمة رسمة
+
+239
+00:19:20,330 --> 00:19:24,370
+بحيث تحتمل او جهود اختلاف في القراءات الأخرى أو في
+
+240
+00:19:24,370 --> 00:19:29,690
+الأحرف الأخرى ننتقل لك سؤال آخر ما هي صلة القراءات
+
+241
+00:19:29,690 --> 00:19:35,730
+بالأحرف السبعة؟ هل الأحرف السبعة نفسها القراءات
+
+242
+00:19:35,730 --> 00:19:41,970
+السبعة ولا العشرة؟ ولا تختلف؟ ما رأيكم؟في عندنا
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+243
+00:19:41,970 --> 00:19:46,030
+أحرف سبعة القرآن نزل على سبعة أحرف كما علمنا النبي
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+244
+00:19:46,030 --> 00:19:50,630
+عليه الصلاة والسلام ولكن الآن لا يوجد أحرف سبعة
+
+245
+00:19:50,630 --> 00:19:54,910
+وإنما يوجد عندنا قراءات سبعة و لا عشرة أو أربعة
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+246
+00:19:54,910 --> 00:19:57,770
+عشر في عندنا تحافظ رأى البشر في القراءات الأربعة
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+247
+00:19:57,770 --> 00:20:02,370
+عشر ما هي صلة الأحرف السبعة أو القراءات بالأحرف
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+248
+00:20:02,370 --> 00:20:07,180
+السبعة؟ هل هناك صلة؟ فضل أختيوهي جزء من الأحرف
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+249
+00:20:07,180 --> 00:20:11,660
+السابعة صحيح القراءات يا أخوات هي بقايا الأحرف
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+250
+00:20:11,660 --> 00:20:16,840
+السابعةوجزء من الأحرف السبعة التي وصلتنا متواترة
+
+251
+00:20:16,840 --> 00:20:20,680
+يعني مثلا عاصم ابن أبو النجوم الذي طلق العلم عن
+
+252
+00:20:20,680 --> 00:20:26,000
+أبي عبد الرحمن السلمي اشتهر بأنه كان يعني يأخذ غير
+
+253
+00:20:26,000 --> 00:20:29,880
+ما هو موجود في المصحف عثمان بعض الروايات الموجودة
+
+254
+00:20:29,880 --> 00:20:34,080
+التي أخذها عن الرسول عليه الصلاة والسلام يقول فلان
+
+255
+00:20:34,080 --> 00:20:38,640
+يقرأ بصيغة كذا واشتهرت عليه هذه بعض الكلمات ولذلك
+
+256
+00:20:38,640 --> 00:20:44,470
+سميت قراءة ورش أي قراءة حفصعن عاصم .. قراءة عاصم
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+257
+00:20:44,470 --> 00:20:49,950
+ابن أبي النجول إذا القراءات السبعة ليست هي الأحرف
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+258
+00:20:49,950 --> 00:20:55,530
+السبعة وإنما هي بقايا الأحرف السبعة لأن عثمان بن
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+259
+00:20:55,530 --> 00:21:00,170
+عفان عندما جمع المصحف جمعه على حرف واحد وهو أي
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+260
+00:21:00,170 --> 00:21:08,240
+حرف؟ حرف قريش لماذا حرف قريش بالذات؟ لأنه ..هو لغة
+
+261
+00:21:08,240 --> 00:21:11,980
+الرسول عليه الصلاة والسلام ونزل القرآن بداية على
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+262
+00:21:11,980 --> 00:21:14,940
+حرف قريش و بعد ذلك في المدينة نزل القرآن على سبعة
+
+263
+00:21:14,940 --> 00:21:19,600
+أحرف و لأنه أبلغ الحروف و أفصح الحروف و أشهر
+
+264
+00:21:19,600 --> 00:21:22,800
+الحروف لأنه كانت القبائل العربية تأتي من كل
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+265
+00:21:22,800 --> 00:21:27,240
+الجزيرة العربية إلى المكة المكرمة للحج فكانت اللغة
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+266
+00:21:27,240 --> 00:21:31,160
+المشهورة و المعروفة و المعهودة و أبلغ اللغات لغة
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+267
+00:21:31,160 --> 00:21:35,340
+قريش لأن ذلك عثمان بن عفان لما جمع المصحف جمعه على
+
+268
+00:21:35,340 --> 00:21:41,810
+حرفحرف واحد هو حرف قريش و لكنه رسم رسما بدون نقاط
+
+269
+00:21:41,810 --> 00:21:45,850
+و بدون تشكيل ليحتمل أوجه الاختلاف في القراءات
+
+270
+00:21:45,850 --> 00:21:50,170
+الأخرى فكان ذلك هناك علاقة ما بعد ذلك اشتهرت
+
+271
+00:21:50,170 --> 00:21:56,970
+القراءات و صارت القراءات هي جزء من الأحرف السبعة
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+272
+00:21:56,970 --> 00:22:02,190
+عندنا يا أخوات أيضا بعض التعريفات التي لابد أن
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+273
+00:22:02,190 --> 00:22:07,640
+نتعرف عليها كمقدمة في علم القراءاتأول شي القراءات
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+274
+00:22:07,640 --> 00:22:13,580
+لغة جمع قراءة و هي مأخوذة القراءة .. مأخوذة إذ هي
+
+275
+00:22:13,580 --> 00:22:18,560
+مصدر .. مأخوذة من القرء بمعنى الجمع والضم أو
+
+276
+00:22:18,560 --> 00:22:25,480
+مأخوذة من تلا .. تلا يعني من قرأ بمعنى تلاوكأن
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+277
+00:22:25,480 --> 00:22:30,840
+الذي يقرأ القراءة أو الكلمات هو يجمع ويضم الحروف
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+278
+00:22:30,840 --> 00:22:35,760
+بعضها إلى بعض ويقرأها إذا كلمة القراءات من حيث
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+279
+00:22:35,760 --> 00:22:43,320
+اللغة القراءات جمع قراءة والقراءة من الفعل قرأة
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+280
+00:22:43,320 --> 00:22:50,990
+وقرأة من القرء بمعنى الضم والجمع في اللغةأو من قرأ
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+281
+00:22:50,990 --> 00:22:56,410
+بمعنى تلا وكأن الذي يقرأ يجمع ويضم الحروف مع بعضها
+
+282
+00:22:56,410 --> 00:23:02,250
+البعض فتصبح الحروف كلمة وتصبح الكلمات جمل ويتلوها
+
+283
+00:23:02,250 --> 00:23:06,810
+أو يقراها فتصبح قراءة هذه من حيث اللغة وهناك علاقة
+
+284
+00:23:06,810 --> 00:23:11,250
+ما بين التعليف اللغوي والتعليف الاصطلاحي لمعنى
+
+285
+00:23:11,250 --> 00:23:15,630
+قراءةأما القراءة من حيث الإصطلاح يعني لو واحد قرأ
+
+286
+00:23:15,630 --> 00:23:21,230
+كتاب أو قرأ قرآن فهو معناه في التعريف الإصطلاحي ضم
+
+287
+00:23:21,230 --> 00:23:25,610
+الحروف والكلمات بعضها إلى بعض في القراءة أو
+
+288
+00:23:25,610 --> 00:23:30,430
+الترتيبيعني أوراد أن يقرأ كتاب عبارة عن الحروف
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+289
+00:23:30,430 --> 00:23:34,650
+نضمها فتصبح الحروف كلمات والكلمات نجمعها و نضمها
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+290
+00:23:34,650 --> 00:23:38,790
+فتصبح الكلمات جمال و يقرأها سواء يريد أن يقرأ من
+
+291
+00:23:38,790 --> 00:23:44,570
+كتاب ولا يريد أن يقرأ قراءة من المصحف فالقراءة من
+
+292
+00:23:44,570 --> 00:23:49,070
+حيث الإصطلاح كقراءة ليست قراءة قرأنية إنما قراءة
+
+293
+00:23:49,070 --> 00:23:53,550
+من كتاب هي ضم الحروف والكلمات بعضها إلى بعض في
+
+294
+00:23:53,550 --> 00:23:58,750
+القراءة أو الترتيرأما بالنسبة لعلم القراءات الذي
+
+295
+00:23:58,750 --> 00:24:04,490
+نحن بصدد الحديث عنه علم القراءات يا أخوات هو علم
+
+296
+00:24:04,490 --> 00:24:09,330
+بكيفية أداء كلمات القرآن واختلافها معزوة لناقله
+
+297
+00:24:09,330 --> 00:24:14,810
+علم بكيفية أداء الكلمات القرأنية واختلافها معزوة
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+298
+00:24:14,810 --> 00:24:20,720
+لناقله من ناقله؟اللي هو الإيمان يعني هو علم بكيفية
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+299
+00:24:20,720 --> 00:24:24,280
+أداء الكلمات القرأنية يعني كيف تؤد هذه الكلمة؟
+
+300
+00:24:24,280 --> 00:24:28,780
+الكلمة نفسها ولكن ممكن أن تؤدى بالترقيب ولا
+
+301
+00:24:28,780 --> 00:24:33,480
+بالتفخيم بالإيمالة ولا بغير الإيمالة؟ بالهمز ولا
+
+302
+00:24:33,480 --> 00:24:37,480
+بالتسهيل؟ يعني مثلا نقول المؤمنون نحن نقراها
+
+303
+00:24:37,480 --> 00:24:41,320
+بالهمز المؤمنون هناك قراءة المؤمنون مثلا قراءات
+
+304
+00:24:41,320 --> 00:24:46,960
+أخرىيعني علم بكيفية أداء هذه الكلمات القرأنية
+
+305
+00:24:46,960 --> 00:24:52,400
+واختلافها يعني تختلف قراية حفص عن عاصم .. عن ..
+
+306
+00:24:52,400 --> 00:24:56,980
+حفص عن عاصم عن ورش عن نافع عن قراية كده وكده معزوة
+
+307
+00:24:56,980 --> 00:25:01,460
+لناقله يعني لابد أن نذكر الإمام نقول والله قراية
+
+308
+00:25:01,460 --> 00:25:05,880
+ورش عن نافع اللي هو الإمام نافع كده وكده قراية حفص
+
+309
+00:25:05,880 --> 00:25:11,120
+عن عاصم كده وكده إذا من يقول لي أو يعرف لي علم
+
+310
+00:25:11,120 --> 00:25:21,000
+القراءاتمن يعرف لي علم القراءات؟ اتفضل أخت صحيح
+
+311
+00:25:21,000 --> 00:25:25,340
+علم بكيفية أداء الكلمات القرأنية واختلافها مع ذو
+
+312
+00:25:25,340 --> 00:25:30,920
+اللي ناقله وناقله المفصوض به هو الإمام طيب في عند
+
+313
+00:25:30,920 --> 00:25:36,300
+أخوات قراءات متوافرة وقراءات صحيحة وقراءات يعني
+
+314
+00:25:36,300 --> 00:25:43,190
+غير صحيحةالقراءة المتواترة ما هو تعريف القراءة
+
+315
+00:25:43,190 --> 00:25:47,990
+المتواترة؟ طبعا العلماء وضعوا لها شروط وعرفوها
+
+316
+00:25:47,990 --> 00:25:52,150
+وشروط القراءة المتواترة موجودة في التعريف نفسه من
+
+317
+00:25:52,150 --> 00:25:55,430
+يعرف لي القراءة المتواترة؟ اتفضل أختك
+
+318
+00:25:59,400 --> 00:26:03,700
+مثلاني ولا تقرير؟ أحسن تقرأ وتقرأ نقلها إذا كل
+
+319
+00:26:03,700 --> 00:26:07,240
+قراءة وافقة اللغة العربية لابد أن تكون القراءة
+
+320
+00:26:07,240 --> 00:26:10,900
+موافقة للغة العربية كيف يمكن أن تكون موافقة للغة
+
+321
+00:26:10,900 --> 00:26:15,180
+العربية؟ يعني الفاعل بيكون مرفوع لو جاءت قراءة
+
+322
+00:26:15,180 --> 00:26:20,190
+وقرأت جاء المؤمنينبنقول خطأ خطأ لأنه القرآن نزل
+
+323
+00:26:20,190 --> 00:26:25,070
+بلسان عربي مبين لو قلنا جاء المؤمنين هي لأ جاء
+
+324
+00:26:25,070 --> 00:26:30,090
+المؤمنون مثلا و جاء رجل ما بنفع نقول و جاء رجلا
+
+325
+00:26:30,090 --> 00:26:34,650
+فإذا كانت القراءة مخالفة للغة العربية فهي شاذة لا
+
+326
+00:26:34,650 --> 00:26:39,470
+نقبلها إذا لابد أن يكون الفعل مرفوع و المفعول به
+
+327
+00:26:39,470 --> 00:26:45,150
+منصوب سواء كمنصوب باليا و لا منصوب بالفتحة و هكذا
+
+328
+00:26:45,150 --> 00:26:50,230
+لابد أن يكون موافق للغة العربيةكل قراءة أو هي كل
+
+329
+00:26:50,230 --> 00:26:55,150
+قراءة وافقت للغة العربية مطلقا ووافقت رسم المصحف
+
+330
+00:26:55,150 --> 00:27:00,810
+العثماني ولو تقديرا وتواتر نقلها فهي قراءة متواترة
+
+331
+00:27:00,810 --> 00:27:05,930
+ومن هنا .. من هذا التعريف نستطيع أن نذكر الشروط
+
+332
+00:27:05,930 --> 00:27:10,550
+التي وضعها العلماء لتكون القراءة قراءة متواترة من
+
+333
+00:27:10,550 --> 00:27:14,830
+يذكر لي استنبط الشروط من هذا التعريف اتفضلي
+
+334
+00:27:30,600 --> 00:27:34,640
+النقطة الأولى الشرط الأول أن تكون موافقة للغة
+
+335
+00:27:34,640 --> 00:27:39,550
+العربيةالشرط الثاني لابد أن تكون موافق للرسم
+
+336
+00:27:39,550 --> 00:27:43,750
+العثماني ولو تقديرا، كيف؟ ولو تقديرا، يعني في
+
+337
+00:27:43,750 --> 00:27:49,230
+عندنا قراءة جنات تجري تحتها الأنهار، قراءة أخرى
+
+338
+00:27:49,230 --> 00:27:54,270
+جنات تجري من تحتها الأنهاريعني بزيادة حرف من
+
+339
+00:27:54,270 --> 00:27:59,930
+تقديرا ان من تحتها يعني من بعضها و ليست كل الجنات
+
+340
+00:27:59,930 --> 00:28:03,390
+فوجود حرف من صحيح انه زيادة على الرسم العثماني
+
+341
+00:28:03,390 --> 00:28:08,930
+لكنه بيفهمنا المقصود ان جنات تجري تحتها الأنهار
+
+342
+00:28:09,640 --> 00:28:14,220
+قراقة أخرى جنات تجري من تحتها الأنهار يعني من
+
+343
+00:28:14,220 --> 00:28:18,660
+بعضها لأنه ليست كل الجنات تجري من تحتها الأنهار
+
+344
+00:28:18,660 --> 00:28:24,180
+وإنما الجنة مواطن جنات يعني تجري من تحتها الأنهار
+
+345
+00:28:24,180 --> 00:28:27,700
+يعني من بين قصونها ولا في جنات أحيانا لا تجري من
+
+346
+00:28:27,700 --> 00:28:31,940
+تحتها الأنهار بينتقد إنسان مؤمنفي أهل الجنة ما بين
+
+347
+00:28:31,940 --> 00:28:36,020
+هذه الجنة و هذه الجنة والله أعلم إذا أنها وافقة
+
+348
+00:28:36,020 --> 00:28:40,380
+رسم المصحف ولو تقديرا وتواترا نقلها ما معناه يا
+
+349
+00:28:40,380 --> 00:28:45,760
+أخوات وتواترا نقلها بالإذن لو سمحتوا ما معناه
+
+350
+00:28:45,760 --> 00:28:54,620
+المتواترة أخدته في الحديث هو ما رواهجمع عن جمع في
+
+351
+00:28:54,620 --> 00:28:58,720
+كل طبقة من طبقات السند تحيي للعالم تواطئهم على
+
+352
+00:28:58,720 --> 00:29:02,280
+الكذب يعني النبي عليه الصلاة والسلام نزل عليه
+
+353
+00:29:02,280 --> 00:29:07,100
+جبريل بالقرآن فجبريل علمه للصحابة و الصحابة عدد
+
+354
+00:29:07,100 --> 00:29:12,520
+كبير جدا يعني يقول بعض العلماء 120 ألف صحاب يعني
+
+355
+00:29:12,520 --> 00:29:18,240
+حافظوا القرآن بمجموعهم متواتراوالصحابة علموه
+
+356
+00:29:18,240 --> 00:29:22,760
+للتابعين والتابعون علموه لأتباع التابعين وهكذا حتى
+
+357
+00:29:22,760 --> 00:29:29,000
+وصل إلينا القراءة المتواترة هو يعني ما رواه جمع عن
+
+358
+00:29:29,000 --> 00:29:33,320
+جمع في كل طبقة من طبقات السند تحيي للعادة تواطؤهم
+
+359
+00:29:33,320 --> 00:29:36,640
+على الكذب إذا لابد أن تكون القراءة وصلت لعاصم
+
+360
+00:29:36,640 --> 00:29:40,240
+متواترة ليست من واحد من خمسين ستين أو مائة واحد
+
+361
+00:29:40,240 --> 00:29:45,140
+وصلتله فبتكون القراءة متواترة إذا تعريف القراءة
+
+362
+00:29:45,140 --> 00:29:49,810
+المتواترةهو كله قراءة وافقة اللغة العربية مطلقا
+
+363
+00:29:49,810 --> 00:29:55,150
+ووافقة رسم المصحف العثماني ولو تقديرا وتواتر نقلها
+
+364
+00:29:55,150 --> 00:29:59,790
+فهي قراءة متواترة ويلحق بالقراءات المتواترة
+
+365
+00:29:59,790 --> 00:30:05,230
+السابعة هناك كمان ثلاث قراءات كما ذكرها ابن الجزري
+
+366
+00:30:05,230 --> 00:30:11,050
+وهي في كتابه النشر في القراءات العشريجمع تلات
+
+367
+00:30:11,050 --> 00:30:14,250
+قراءات يعني بقى سبعة زائد تلات عشر قراءات متواترة
+
+368
+00:30:14,250 --> 00:30:20,010
+والعشر قراءات أخوات المتواترة يقرأوا بها ونتعبد
+
+369
+00:30:20,010 --> 00:30:26,090
+الله بها ونصل بها فهي كلها قرآن وكلها يعني يجوز
+
+370
+00:30:26,090 --> 00:30:30,100
+لنا أن نتعبد الله بهاكما جاء في كتاب النشر في
+
+371
+00:30:30,100 --> 00:30:33,800
+القراءات العشر أما القراءات الصحيحة الأربعة لا
+
+372
+00:30:33,800 --> 00:30:37,980
+نصلّي بها وإنما نأخذ بها من باب التفسير والفهم
+
+373
+00:30:37,980 --> 00:30:42,460
+لآيات القرآن الكلمة كذلك من ضمن التعريفات التي سوف
+
+374
+00:30:42,460 --> 00:30:46,980
+ندرسها في هذه المقدمة عن علم القراءات تعريف
+
+375
+00:30:46,980 --> 00:30:52,160
+القراءة في قراءة اسمها قراءة قرأنية ما هو تعريف
+
+376
+00:30:52,160 --> 00:30:57,210
+القراءة القرأنية؟ ما رأيكم؟ اتفضليهو الاختيار
+
+377
+00:30:57,210 --> 00:31:00,150
+المنسوب لأحد الأئمة العشرة في كيفية قراءة لف
+
+378
+00:31:00,150 --> 00:31:02,630
+القرآن مما رواه بسنده عن النبي صلى الله عليه وسلم
+
+379
+00:31:02,630 --> 00:31:06,990
+أحسن هو الاختيار المنسوب لأحد الأئمة العشرة يعني
+
+380
+00:31:06,990 --> 00:31:11,790
+نقول مثلا عاصم ابن ابن نجود، نافع، حمزة الزياد،
+
+381
+00:31:11,790 --> 00:31:15,590
+ابن عامر، الكسائي من هؤلاء القراءات يبقى اختيار
+
+382
+00:31:15,590 --> 00:31:20,510
+منسوب .. يعني نصف هذا الاختيار في قراءة اللفظة
+
+383
+00:31:20,510 --> 00:31:25,450
+الفلانية للإمام فلان الفلان في كيفية قراءة لفظة
+
+384
+00:31:25,530 --> 00:31:30,030
+قرآنية مما رواه بسنده عن النبي عليه الصلاة
+
+385
+00:31:30,030 --> 00:31:36,010
+والسلام. لو سألنا حفص ابن سليمان عن من أخذ القراءة
+
+386
+00:31:36,010 --> 00:31:43,460
+عن عاصمعاصم ابن ابن نجود عاما أخذ القراءة عن أبي
+
+387
+00:31:43,460 --> 00:31:47,760
+عبد الرحمن السلمي وهو المقرء الذي أرسله عثمان ابن
+
+388
+00:31:47,760 --> 00:31:52,880
+عفان ليقرأ الناس القرآن في الكوفة أو العراق أبو
+
+389
+00:31:52,880 --> 00:31:57,480
+عبد الرحمن السلم أخذ القراءة عنهعليه ابن أبي طالب
+
+390
+00:31:57,480 --> 00:32:01,720
+وعن غيره وعليه ابن أبي طالب أخذها عن النبي عليه
+
+391
+00:32:01,720 --> 00:32:07,040
+الصلاة والسلام فالقراءة متواصلة بالسند إذا القراءة
+
+392
+00:32:07,040 --> 00:32:11,740
+هي اختيار المنسوب لأحد الأئمة العشرة في كيفية
+
+393
+00:32:11,740 --> 00:32:17,100
+قراءة لفظ قرآني مما رواه بسنده عن النبي صلى الله
+
+394
+00:32:17,100 --> 00:32:22,460
+عليه وسلم فيقالوا قراءة نافعةأو قراءة حمزة أو
+
+395
+00:32:22,460 --> 00:32:26,780
+قراءة عاصم أو قراءة الكسائي أو قراءة حمزة الزياد
+
+396
+00:32:26,780 --> 00:32:30,880
+أو قراءة ابن عمر أو قراءة جعفر أو أي قراءة من هذه
+
+397
+00:32:30,880 --> 00:32:35,720
+القراءات التي هي قراءات متواترة عن النبي صلى الله
+
+398
+00:32:35,720 --> 00:32:40,740
+عليه وسلم طيب هذه عرفنا القراءةوالاختيار المنصوب
+
+399
+00:32:40,740 --> 00:32:44,920
+لأحد الأئمة في كذلك يا أخوات في عندنا رواية احنا
+
+400
+00:32:44,920 --> 00:32:52,280
+نقول رواية حفص عن عاصم اذا الراوي هيكون ايش؟ حفص
+
+401
+00:32:52,280 --> 00:32:59,040
+بيروي عن القارئ عاصم برواية حفص عن عاصم فالرواية
+
+402
+00:32:59,040 --> 00:33:04,240
+هي كل ما نسبة لأحد الرواية عن أحد الأئمة العشرة
+
+403
+00:33:04,240 --> 00:33:08,700
+فالإمام من الأئمة العشرة .. أحد الأئمة العشرةوهو
+
+404
+00:33:08,700 --> 00:33:14,840
+عندنا عاصم، من الذي روى عن عاصم؟ حفص، إذا حفص بن
+
+405
+00:33:14,840 --> 00:33:20,600
+سليمان هو الراوي عن عاصم وكذلك شعبان بن عياش أيضا
+
+406
+00:33:20,600 --> 00:33:25,520
+روى عن عاصم، هيسمى راوي، فالرواية هي كل ما نسبة
+
+407
+00:33:25,520 --> 00:33:30,270
+لأحدمن أحد الأئمة من أحد الرواية عن أحد الأئمة
+
+408
+00:33:30,270 --> 00:33:36,790
+العشرة فيقال رواية حفظ عن عاصم رواية شعبة عن عاصم
+
+409
+00:33:36,790 --> 00:33:42,690
+رواية ورش عن نافع رواية الوزي عن ابن كثير وهكذا
+
+410
+00:33:42,690 --> 00:33:48,370
+بتسمى رواية طيب هذه الرواية اللي هو حفظ عن عاصم
+
+411
+00:33:48,370 --> 00:33:56,030
+ورش عن نافع من الذي نقلها إلينا؟من اللي نقلها
+
+412
+00:33:56,030 --> 00:34:02,090
+إلينا واحد سواء كان إنسان ولا حتى على بعد منها
+
+413
+00:34:02,090 --> 00:34:07,590
+كتاب مثلا من طريق عبيد بن الصباح من طريق عبيد بن
+
+414
+00:34:07,590 --> 00:34:12,470
+الصباح هذا أحد الأئمة أو أحد العلماء نقلنا عن حفص
+
+415
+00:34:12,470 --> 00:34:18,090
+بن سليمانوحفظ ابن سلم من نقل عن عاصم ابن ابن نجود
+
+416
+00:34:18,090 --> 00:34:24,190
+هذه تسمى طريق، إذا الطريق هو كل ما نسبه لمن نقل عن
+
+417
+00:34:24,190 --> 00:34:29,410
+الراوي وإنس فلان يبقى اللي بنقل عن الراوي اسمه من
+
+418
+00:34:29,410 --> 00:34:36,430
+طريق فلان الراوي بينقل عن الإمام ويسمى راوي الراوي
+
+419
+00:34:36,430 --> 00:34:42,200
+.. القراء الإمام بيقرأ القراوي يسمى إمامإذا قرأتنا
+
+420
+00:34:42,200 --> 00:34:49,140
+نحن عن طريق وصلت إلينا من طريق عبيد بن الصلاح عن
+
+421
+00:34:49,140 --> 00:34:56,020
+الراوي حفص بن سليمان عن الإمام اللي هو عاصم بن أب
+
+422
+00:34:56,020 --> 00:34:59,880
+النجود وعاصم أخذ عن أبي عبد الرحمن السلمي وابو عبد
+
+423
+00:34:59,880 --> 00:35:04,400
+الرحمن السلمي أخذ عن علي بن أبي طالب وعلي أخذ عن
+
+424
+00:35:04,400 --> 00:35:09,120
+الرسول صلى الله عليه وسلمالتعريف يا أخوات يقول هو
+
+425
+00:35:09,120 --> 00:35:15,100
+كل ما نسبه لمن نقل عن الراوي وإن سفل ما معناه سفل؟
+
+426
+00:35:15,100 --> 00:35:20,700
+يعني وإن بعدت المسافة ما بين الراوي والطريق اللي
+
+427
+00:35:20,700 --> 00:35:25,220
+نقلها إلينا مثلا من طريق الشاطبية يعني بعد عدة
+
+428
+00:35:25,220 --> 00:35:32,860
+رواة حدثناهم حدثنا السند ونقلت الشاطبية عن حفظ بن
+
+429
+00:35:32,860 --> 00:35:38,500
+سليمانأو طيبة النشر عن حفص ابن سليمان لكن الطيبة
+
+430
+00:35:38,500 --> 00:35:44,920
+ده كتاب كتاب أما ما بين الطيبة النشر أو الشاطبية
+
+431
+00:35:44,920 --> 00:35:49,860
+ما بينها وبين حفص ابن سليمان كام رواي محدثين عدة
+
+432
+00:35:49,860 --> 00:35:55,700
+رواي لكننا مع هذا بنقول من طريق الشاطبية عن حفص
+
+433
+00:35:55,700 --> 00:35:59,970
+ابن سليمان عن عاصم ابن أبن نجودأو من طريق طيبة
+
+434
+00:35:59,970 --> 00:36:04,750
+النشر عن حفص بن سلمان عن عاصم ابن أبن نجود هذه
+
+435
+00:36:04,750 --> 00:36:09,330
+تسمى يا أخوات طريقة إذا .. إذا الطريق هو كل .. كل
+
+436
+00:36:09,330 --> 00:36:13,130
+ما نسبه لمن نقل عن الراوي اللي نقل عن الراوي
+
+437
+00:36:13,130 --> 00:36:16,810
+بنسميه طريق الراوي اللي بينقل عن الإمام بنسميه
+
+438
+00:36:16,810 --> 00:36:20,230
+رواية الإمام اللي بينقل عن الرسول عليه الصلاة
+
+439
+00:36:20,230 --> 00:36:24,530
+والسلام بالسند بنسميه إمام أو بنسميه إيش؟ بنسميه
+
+440
+00:36:24,530 --> 00:36:30,240
+قراءةومن هنا في عنا قراء الآن نريد أن ناخد
+
+441
+00:36:30,240 --> 00:36:37,280
+القراءات العشرة الروابط بس نذكر ذكر طبعا كل إمام
+
+442
+00:36:37,280 --> 00:36:43,020
+من الأئمة تتلمذ على يديه ممكن أن نقول آلاف من طلبة
+
+443
+00:36:43,020 --> 00:36:49,940
+العلم لكن الكتاب ذكر هنا لكل إمام راوين مثلا عاصم
+
+444
+00:36:49,940 --> 00:36:56,500
+ابن أبن نجود وهو شيخ القراء بالكوفةروا عنه آلاف من
+
+445
+00:36:56,500 --> 00:37:02,260
+العلماء .. من التلميذ لكننا اخترنا أشهر و أفضل
+
+446
+00:37:02,260 --> 00:37:07,000
+اتنين لأن هو اللي هم .. اللي هم اشتهروا و طال
+
+447
+00:37:07,000 --> 00:37:12,640
+عمرهم حتى بلغ أحدهم 98 سنة و هو يدرس الناساه ايه
+
+448
+00:37:12,640 --> 00:37:16,320
+يعني اشتهرت هذه القراءة؟ اللي هو حفص بن سليمان
+
+449
+00:37:16,320 --> 00:37:22,100
+اللي توفي و عمره تسعين سنة و كذلك شعبة ابن عياش
+
+450
+00:37:22,100 --> 00:37:25,900
+اللي توفي و عمره تمانية وتسعين سنة يعني خمسين،
+
+451
+00:37:25,900 --> 00:37:29,540
+ستين و لا سبعين أو تمانية سنة و هو قاعد بدرس يعني
+
+452
+00:37:29,540 --> 00:37:37,590
+هذا شعبة ابن عياش مثلا بدرس الأب او الأبنأو
+
+453
+00:37:37,590 --> 00:37:43,350
+للتلميذ و ابنه و ابن ابنه و ابن ابن ابنه يعني 80
+
+454
+00:37:43,350 --> 00:37:49,670
+سنة هو قاعد بدرس أكيد هذه السلسلة تركت له تلميذ
+
+455
+00:37:49,670 --> 00:37:54,170
+بالآلاف وبالتالي عاصم ابن أبن نجود و هو إمامنا
+
+456
+00:37:54,170 --> 00:37:58,730
+إمام القراءة التي ندرس بها له تلميذان حفص بن
+
+457
+00:37:58,730 --> 00:38:03,330
+سليمان و شعبة بن عياش كذلك نافع .. طبعا هذه
+
+458
+00:38:03,330 --> 00:38:07,910
+المطلوبة منكمأما باقي القراءات نريد أن نذكرها ذكرا
+
+459
+00:38:07,910 --> 00:38:12,070
+ويعني هناك مادة تسمى القراءات تدرسوها بالتفصيل
+
+460
+00:38:12,070 --> 00:38:18,650
+عندنا مثلا الإمام نافع ابن عبدالرحمن المدني له
+
+461
+00:38:18,650 --> 00:38:23,910
+تلميذان هما قالون وورش وهم اللتي ندرسها أو نقراها
+
+462
+00:38:23,910 --> 00:38:29,850
+ورش عن نافع أو قالون عن نافع ابن كثير له تلميذان
+
+463
+00:38:29,850 --> 00:38:36,450
+أيضا اللي هو البزي وقنبلأبو عمر البصري له تلميذان
+
+464
+00:38:36,450 --> 00:38:42,890
+الدوري والسوسي ابن عمر الشامي له تلميذان هشام وابن
+
+465
+00:38:42,890 --> 00:38:46,970
+ذاكوان حمزة الزيات .. الإمام حمزة الزيات أيضا
+
+466
+00:38:46,970 --> 00:38:54,610
+نختار له تلميذان خلاف وخلد .. خلاف وخلاد أقصد ..
+
+467
+00:38:54,610 --> 00:38:58,870
+الإمام الكسائي له تلميذان أبو الحارث الليت
+
+468
+00:38:58,870 --> 00:39:04,470
+البغدادي والدوريالإمام أبو .. طبعا الدون يتكرر مع
+
+469
+00:39:04,470 --> 00:39:08,410
+أبي عمر البصري بيكون أخذ من هذا و أخذ من هذا يعني
+
+470
+00:39:08,410 --> 00:39:12,290
+لأن العلماء كانوا يعني يأخذوه من بعضهم البعض فيكون
+
+471
+00:39:12,290 --> 00:39:17,290
+له شيخان اللي هو أبو عمر البصري بالإضافة لأبي جعفر
+
+472
+00:39:17,290 --> 00:39:22,490
+الكسائي أبو جعفر المدني أيضا له تلميذان ابن وردان
+
+473
+00:39:22,490 --> 00:39:27,130
+وابن جماز الإمام يعقوب الحضرمي له تلميذان رويس
+
+474
+00:39:27,130 --> 00:39:32,510
+وروحالإمام خلف البزار أيضا له تلميذان اللي هو
+
+475
+00:39:32,510 --> 00:39:37,450
+إسحاق المروزي و إدريس هؤلاء الأئمة العشرة و بعد
+
+476
+00:39:37,450 --> 00:39:43,510
+ذلك الأربعة تعد قراءتهم .. صحيح لأ نحفظ بس روايتنا
+
+477
+00:39:43,510 --> 00:39:49,440
+حفظ عن عاصم أما أولاك بس للعلم للدراسةأخدنا يا
+
+478
+00:39:49,440 --> 00:39:54,320
+أخوات بالنسبة للقراءة المتواترة لها أركان اللي هي
+
+479
+00:39:54,320 --> 00:39:58,340
+الشروط شروط القراءة المتواترة مثل ما ذكرناها في
+
+480
+00:39:58,340 --> 00:40:02,900
+التعريف أول شيء لابد أن تكون موافقة للرسم لللغة
+
+481
+00:40:02,900 --> 00:40:08,560
+العربية اتنين موافقة للرسم العثماني تلاتة صحة
+
+482
+00:40:08,560 --> 00:40:11,060
+السند وتواتر الرواية يعني تكون الرواية متواترة
+
+483
+00:40:11,060 --> 00:40:15,600
+والسند صحيح موافقة لرسم المصحف وموافقة لللغة
+
+484
+00:40:15,600 --> 00:40:22,130
+العربيةأخر شيء ندرسه نحن وهو مهم جدا، ما هو سند
+
+485
+00:40:22,130 --> 00:40:27,350
+رواية حفص عن عاصم؟ من يدخل ليه الآن ما هو سند
+
+486
+00:40:27,350 --> 00:40:34,590
+رواية حفص عن عاصم؟ ذكرته عدة برات؟ أه، مين عارف؟
+
+487
+00:40:34,590 --> 00:40:41,070
+جدانكم، فضلي حفص ابن سليمان
+
+488
+00:40:41,070 --> 00:40:43,830
+أخد سماعا عن عاصم ابن ابن نجوم
+
+489
+00:40:46,990 --> 00:40:50,810
+أحسن مين كمان من يذكر يدي السند؟ طبعا هذا يا أخوان
+
+490
+00:40:50,810 --> 00:40:54,930
+يجان دائما يأتي لأن هو مهم و هو الفايصة اللي عندنا
+
+491
+00:40:54,930 --> 00:40:58,290
+اذكري السند رواية .. الرواية التي يقرا بها أهل
+
+492
+00:40:58,290 --> 00:41:02,850
+الشام أو اذكري السند رواية حفص عن عاصم هتقولي يعني
+
+493
+00:41:02,850 --> 00:41:07,830
+حفص ابن سليمان أخذ سماعا عن عاصم ابن أبي النجود
+
+494
+00:41:07,830 --> 00:41:12,270
+عاصم أخذ عن أبي عبد الرحمن السلمي سماعا أيضا لأنه
+
+495
+00:41:12,270 --> 00:41:16,200
+كان تلميذهأبو عبد الرحمن السلمي أخذ عن علي بن أبي
+
+496
+00:41:16,200 --> 00:41:19,620
+طالب وعلي بن أبي طالب أخذه عن رسول الله صلى الله
+
+497
+00:41:19,620 --> 00:41:23,580
+عليه وسلم و هذه الهواية وصلتنا من طريق الشياطبية
+
+498
+00:41:23,580 --> 00:41:28,900
+عن عبيد بن الصباح عن حفص بن سلمان إلى نهاية السنة
+
+499
+00:41:29,090 --> 00:41:32,790
+أنهينا الآن يا أخوات مقدمة في القراءات وإن شاء
+
+500
+00:41:32,790 --> 00:41:36,370
+الله في المحاضرة القادمة سوف نأخذ مقدمة في علم
+
+501
+00:41:36,370 --> 00:41:39,910
+التجويض لأنه بداية علم التجويض أخذنا العديد من
+
+502
+00:41:39,910 --> 00:41:43,130
+المقدمات نكتفي بهذا القدر وبرك الله فيكم السلام
+
+503
+00:41:43,130 --> 00:41:44,450
+عليكم ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HwdAh2TrhaI_raw.json b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HwdAh2TrhaI_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..263e154a165f9b46e8edcf24f08b0e44e5b5f045
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/HwdAh2TrhaI_raw.json
@@ -0,0 +1 @@
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{"start": 194.94, "end": 195.42, "word": " سقوطي", "probability": 0.86259765625}, {"start": 195.42, "end": 196.4, "word": " هامستر", "probability": 0.749542236328125}, {"start": 196.4, "end": 196.6, "word": " واصل", "probability": 0.7066243489583334}, {"start": 196.6, "end": 196.72, "word": " هو", "probability": 0.568359375}, {"start": 196.72, "end": 197.16, "word": " لقبله", "probability": 0.610809326171875}, {"start": 197.16, "end": 197.64, "word": " نريد", "probability": 0.5702311197916666}, {"start": 197.64, "end": 197.76, "word": " أن", "probability": 0.53076171875}, {"start": 197.76, "end": 198.32, "word": " نأتي", "probability": 0.876953125}, {"start": 198.32, "end": 198.74, "word": " بتعريف", "probability": 0.98046875}, {"start": 198.74, "end": 199.58, "word": " شامل", "probability": 0.994140625}, {"start": 199.58, "end": 200.72, "word": " لهامستر", "probability": 0.84783935546875}, {"start": 200.72, "end": 200.94, "word": " واصل", "probability": 0.9939778645833334}, {"start": 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"probability": 0.928955078125}, {"start": 239.64, "end": 239.98, "word": " ماذا", "probability": 0.9013671875}, {"start": 239.98, "end": 240.48, "word": " تسقط", "probability": 0.9796549479166666}, {"start": 240.48, "end": 240.82, "word": " همز", "probability": 0.74951171875}, {"start": 240.82, "end": 241.28, "word": " الوصل", "probability": 0.9095052083333334}, {"start": 241.28, "end": 241.86, "word": " إذا", "probability": 0.916748046875}, {"start": 241.86, "end": 242.38, "word": " وصلت", "probability": 0.98291015625}, {"start": 242.38, "end": 242.64, "word": " بما", "probability": 0.98046875}, {"start": 242.64, "end": 244.26, "word": " قبلها؟", "probability": 0.9488525390625}, {"start": 244.26, "end": 244.76, "word": " تفضلي", "probability": 0.9776611328125}], "temperature": 1.0}, {"id": 13, "seek": 27039, "start": 250.09, "end": 270.39, "text": "صحيح أصلا همسة الوصل هي أصلا زائدة جينا بيها حتى نتوصل للابتداء بالحرف الساكن أما وإن الحرف الساكن قد يعتمد على حرف أصلي قبل همسة الوصل إذا تسقط همسة الوصل ولا حاجة لنا بهمسة الوصل مثال ذلك كلمة اضرب", "tokens": [9381, 5016, 1829, 5016, 5551, 9381, 15040, 8032, 2304, 3794, 3660, 2423, 2407, 36520, 39896, 5551, 9381, 15040, 30767, 16373, 41891, 10874, 1829, 8315, 4724, 1829, 11296, 11331, 49975, 8717, 2655, 2407, 36520, 24976, 16758, 2655, 3215, 16606, 20666, 5016, 28480, 21136, 995, 19452, 5551, 15042, 4032, 28814, 1863, 21542, 28480, 21136, 995, 19452, 12174, 3215, 7251, 34268, 2304, 3215, 15844, 11331, 28480, 5551, 9381, 20292, 12174, 36150, 8032, 2304, 3794, 3660, 2423, 2407, 36520, 11933, 15730, 6055, 3794, 47432, 8032, 2304, 3794, 3660, 2423, 2407, 36520, 49429, 11331, 26108, 3660, 5296, 8315, 4724, 16095, 3794, 3660, 2423, 2407, 36520, 50113, 6027, 29910, 23275, 9122, 19528, 3660, 1975, 11242, 25513], "avg_logprob": -0.08157376099277187, "compression_ratio": 2.0224719101123596, "no_speech_prob": 0.0, "words": [{"start": 250.09, "end": 250.65, "word": "صحيح", "probability": 0.963623046875}, {"start": 250.65, 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{"start": 257.65, "end": 258.45, "word": " الساكن", "probability": 0.9939778645833334}, {"start": 258.45, "end": 259.09, "word": " أما", "probability": 0.850341796875}, {"start": 259.09, "end": 259.47, "word": " وإن", "probability": 0.9466145833333334}, {"start": 259.47, "end": 259.87, "word": " الحرف", "probability": 0.988525390625}, {"start": 259.87, "end": 260.51, "word": " الساكن", "probability": 0.9967447916666666}, {"start": 260.51, "end": 260.77, "word": " قد", "probability": 0.997802734375}, {"start": 260.77, "end": 261.29, "word": " يعتمد", "probability": 0.943603515625}, {"start": 261.29, "end": 261.51, "word": " على", "probability": 0.939453125}, {"start": 261.51, "end": 261.91, "word": " حرف", "probability": 0.992431640625}, {"start": 261.91, "end": 262.45, "word": " أصلي", "probability": 0.95849609375}, {"start": 262.45, "end": 262.91, "word": " قبل", "probability": 0.99658203125}, {"start": 262.91, "end": 263.39, "word": " همسة", "probability": 0.98583984375}, {"start": 263.39, "end": 263.81, "word": " الوصل", "probability": 0.98388671875}, {"start": 263.81, "end": 264.61, "word": " إذا", "probability": 0.73583984375}, {"start": 264.61, "end": 265.21, "word": " تسقط", "probability": 0.984375}, {"start": 265.21, "end": 265.59, "word": " همسة", "probability": 0.9835205078125}, {"start": 265.59, "end": 265.87, "word": " الوصل", "probability": 0.9881184895833334}, {"start": 265.87, "end": 266.11, "word": " ولا", "probability": 0.8056640625}, {"start": 266.11, "end": 266.55, "word": " حاجة", "probability": 0.99560546875}, {"start": 266.55, "end": 266.89, "word": " لنا", "probability": 0.982666015625}, {"start": 266.89, "end": 267.61, "word": " بهمسة", "probability": 0.913818359375}, {"start": 267.61, "end": 267.85, "word": " الوصل", "probability": 0.9835611979166666}, {"start": 267.85, "end": 268.21, "word": " مثال", "probability": 0.947509765625}, {"start": 268.21, "end": 268.59, "word": " ذلك", "probability": 0.986572265625}, {"start": 268.59, "end": 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على حرف أصلي و هو الواو و سقطت همزة الوصل إذا سبب سقوطها أن حرف الكلمة اللي هو حرف الساكن في الكلمة اعتمد على حرف", "tokens": [4117, 8848, 23275, 44713, 17082, 5172, 2288, 44713, 17082, 5172, 2288, 31767, 9957, 34105, 8608, 995, 19452, 3660, 4032, 10874, 1829, 8315, 4724, 5016, 28480, 8032, 2304, 11622, 3660, 2423, 2407, 36520, 11331, 49975, 8717, 2655, 2407, 36520, 2423, 16758, 2655, 3215, 16606, 4724, 5016, 28480, 21136, 995, 19452, 4032, 31439, 31767, 9957, 44381, 11933, 15730, 4032, 36520, 2655, 33251, 19528, 3660, 4724, 15042, 12174, 36150, 11296, 4724, 1829, 30544, 11331, 28480, 31767, 9957, 1975, 34268, 2304, 3215, 15844, 11331, 28480, 5551, 9381, 20292, 4032, 31439, 2423, 14407, 2407, 4032, 8608, 47432, 2655, 8032, 2304, 11622, 3660, 2423, 2407, 36520, 11933, 15730, 8608, 3555, 3555, 8608, 4587, 2407, 9566, 11296, 14739, 11331, 28480, 33251, 19528, 3660, 13672, 1829, 31439, 11331, 28480, 21136, 995, 19452, 8978, 33251, 19528, 3660, 1975, 34268, 2304, 3215, 15844, 11331, 28480], 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بنات؟", "probability": 0.8568115234375}], "temperature": 1.0}, {"id": 34, "seek": 73724, "start": 722.48, "end": 737.24, "text": "همزة قطع كذلك النقطة الثانية تلحظ همزة الوصل في أمر الثلاثي والخماسي والسادسي يعني الفعل عندما يكون ثلاثي الأمر منه همزة وهمزة واصل", "tokens": [3224, 2304, 11622, 3660, 12174, 9566, 3615, 9122, 8848, 23275, 28239, 47432, 3660, 6024, 104, 7649, 10632, 6055, 1211, 5016, 19913, 8032, 2304, 11622, 3660, 2423, 2407, 36520, 8978, 5551, 29973, 6024, 104, 1211, 5718, 104, 1829, 16070, 9778, 15042, 3794, 1829, 16070, 3794, 18513, 3794, 1829, 37495, 22653, 27188, 30241, 43242, 15042, 7251, 30544, 38637, 1211, 5718, 104, 1829, 16247, 29973, 9154, 3224, 8032, 2304, 11622, 3660, 4032, 16095, 11622, 3660, 4032, 33546, 1211], "avg_logprob": -0.13188733474204414, "compression_ratio": 1.791044776119403, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 722.48, "end": 722.94, "word": "همزة", "probability": 0.75872802734375}, {"start": 722.94, "end": 723.26, 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الأول بالنسبة لأمر الثلاثي مثلا قوله فقول نضرب عصاك الحجر فقول نضرب عصاك الحجر هنا اضرب أمر الأيه؟", "tokens": [10721, 2407, 16490, 15042, 3794, 1829, 34051, 8608, 3215, 32277, 1829, 44381, 45164, 25961, 12602, 3555, 45761, 1829, 6156, 16095, 11622, 3660, 4032, 16095, 11622, 3660, 12174, 9566, 3615, 50113, 1211, 5551, 37983, 2304, 5551, 5016, 3794, 1863, 29538, 8032, 2304, 11622, 3660, 4032, 16095, 11622, 3660, 12174, 9566, 3615, 5296, 33456, 3224, 3714, 46958, 1829, 5551, 29973, 34892, 3555, 45761, 1829, 44381, 5551, 29973, 6024, 104, 1211, 5718, 104, 1829, 43242, 8315, 43242, 4117, 5551, 2304, 12984, 37977, 9673, 12984, 6027, 16247, 12610, 20666, 1863, 35457, 3660, 5296, 10721, 29973, 6024, 104, 1211, 5718, 104, 1829, 50113, 15040, 12174, 12610, 3224, 6156, 39648, 8717, 11242, 25513, 6225, 9381, 995, 4117, 21542, 7435, 2288, 6156, 39648, 8717, 11242, 25513, 6225, 9381, 995, 4117, 21542, 7435, 2288, 34105, 1975, 11242, 25513, 5551, 29973, 16247, 1829, 3224, 22807], "avg_logprob": 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الحرف التالت استحفظوا مضموم فهذا تضم همزة الوصلة إذا الحالة الأولى يا أخوات", "tokens": [1211, 33456, 21542, 28480, 16712, 6027, 2655, 3714, 11242, 2304, 20498, 1975, 9566, 46152, 23032, 1829, 3555, 23758, 35186, 5551, 9778, 2407, 9307, 39896, 16712, 1211, 9307, 3660, 29538, 9122, 8848, 23275, 4724, 15042, 44713, 5016, 5172, 19913, 14407, 4724, 15042, 44713, 5016, 5172, 19913, 14407, 44713, 5016, 5172, 19913, 14407, 44713, 5016, 5172, 19913, 14407, 1975, 1829, 11242, 995, 2423, 6076, 2423, 16095, 11622, 3660, 3714, 11242, 2304, 20498, 3660, 5296, 33456, 21542, 28480, 16712, 6027, 2655, 44713, 5016, 5172, 19913, 14407, 3714, 11242, 2304, 20498, 6156, 3224, 15730, 6055, 11242, 2304, 8032, 2304, 11622, 3660, 2423, 2407, 36520, 3660, 11933, 15730, 21542, 6027, 3660, 16247, 12610, 7578, 35186, 5551, 9778, 2407, 9307], "avg_logprob": -0.175951080477756, "compression_ratio": 2.3095238095238093, "no_speech_prob": 2.086162567138672e-06, "words": [{"start": 1190.02, "end": 1190.52, "word": 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\ No newline at end of file
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/I_2IMwtVK0I_raw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/I_2IMwtVK0I_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8ec35d12ecb904315ea39f81807777899086b1b6
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/I_2IMwtVK0I_raw.srt
@@ -0,0 +1,1452 @@
+1
+00:00:12,340 --> 00:00:15,260
+سلام عليكم ورحمة الله وبركاته بسم الله الرحمن
+
+2
+00:00:15,260 --> 00:00:18,980
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+3
+00:00:18,980 --> 00:00:22,620
+آله وصحابه وسلم أخذنا يا أخوات في المحاضرة الماضية
+
+4
+00:00:22,620 --> 00:00:27,320
+همزة الوصل لو سألنا سؤال بسيط من يعرف لنا همزة
+
+5
+00:00:27,320 --> 00:00:33,440
+الوصل؟هي همزة أصلي ولا زائدة زادة عن بنية الكلمة
+
+6
+00:00:33,440 --> 00:00:39,660
+تلحق أول أسماء أو الأفعال أو الحروف تثبت إذا
+
+7
+00:00:39,660 --> 00:00:44,600
+ابتدأنا بيها الكلام وتسقط إذا وصلت بما قبلها و
+
+8
+00:00:44,600 --> 00:00:48,480
+الهمزة الوصل تلحق الأسماء و الأفعال و الحروف نشوف
+
+9
+00:00:48,480 --> 00:00:52,600
+مثلا بالنسبة للأفعال ما هي الأفعال التي تلحق بها
+
+10
+00:00:52,600 --> 00:01:00,280
+همزة الوصل؟ ماضي الخماسي والسداسيماضي الخماسي زي
+
+11
+00:01:00,280 --> 00:01:10,900
+إيش؟ انطلقة، اقتربة، ابتغى، و السداسي استكبرة،
+
+12
+00:01:10,900 --> 00:01:15,760
+استغفرة، استنشقة، استنثرة، و هكذا إذا ماضي الخماسي
+
+13
+00:01:15,760 --> 00:01:20,560
+والسداسي همست و همزة واصل أمر الثلاثي والخماسي
+
+14
+00:01:20,560 --> 00:01:25,100
+والسداسي همزة و همزة واصل أمر الثلاثي من يأتي
+
+15
+00:01:25,100 --> 00:01:30,550
+بكلمة أمر الثلاثياضرب صحيح واضرب لهم مثلا اضرب
+
+16
+00:01:30,550 --> 00:01:37,410
+همزو همزو اتواصل وامر الخماسي انطلقوا او انطلق
+
+17
+00:01:37,410 --> 00:01:41,330
+ايضا امر الخماسي همزو همزو اتواصل امر السداسي
+
+18
+00:01:42,790 --> 00:01:48,270
+استغفر ممتاز استغفر او استنشق او استكبر مثلا كل
+
+19
+00:01:48,270 --> 00:01:52,250
+هذه همزة و همزة واصل اذا ماضي الخماسي والسداسي
+
+20
+00:01:52,250 --> 00:01:56,270
+وامر الثلاثي والخماسي والسداسي هدول بالافعال همزة
+
+21
+00:01:56,270 --> 00:02:00,970
+و همزة واصل طيب حركة همزة الواصل يا أخوات في
+
+22
+00:02:00,970 --> 00:02:04,090
+الأفعال حركة همزة الواصل في الأفعال إما أن تكون
+
+23
+00:02:04,090 --> 00:02:09,000
+مضمومة .. مين اتكلم؟ اتفضل إيه؟ممكن أن تكون مضمومة
+
+24
+00:02:09,000 --> 00:02:14,760
+أو مجسورة و بتكون مضمومة على حسب حركة الحرف التالت
+
+25
+00:02:14,760 --> 00:02:19,020
+من الفعل صحيح بتضموا همسة الوصل إذا كان الحرف
+
+26
+00:02:19,020 --> 00:02:25,600
+التالت من الفعل مضموم مثل ادعوا ادعوا انظر
+
+27
+00:02:25,600 --> 00:02:30,440
+استحفظوا الحرف التالت مضموم فتقرأ الهمسة الوصل إيه
+
+28
+00:02:30,440 --> 00:02:37,020
+شمالها مضمومةكذلك يا أخوات تقصر همثل الوصل في
+
+29
+00:02:37,020 --> 00:02:44,260
+الأفعال لو كان الحرف التالت مفتوح أو مكسور أو
+
+30
+00:02:44,260 --> 00:02:48,640
+مضمون ضمر عرضا اقتربه .. اقتربه هيكسرناه عشان
+
+31
+00:02:48,640 --> 00:02:53,320
+الtaa مفتوحة كذلك مكسور تقصر لو كان الحرف التالت
+
+32
+00:02:53,320 --> 00:03:01,080
+مكسور مثل اضرباه استغفر استغفر المفتوحة اضرب مثلا
+
+33
+00:03:01,080 --> 00:03:05,080
+هذا ماكسورة طيب كذا تكسر همس الوصل لو كان الحرف
+
+34
+00:03:05,080 --> 00:03:09,280
+التالت مضمون ضمن عرضا وهذا لا يقع إلا في كام كلمة
+
+35
+00:03:09,280 --> 00:03:16,740
+خمس كلمات وهياقضوا، ابنوا، امشوا، اقتوا، امضوا هذه
+
+36
+00:03:16,740 --> 00:03:21,300
+الكلمات الخامسة همزتها .. همزت وصل مكسورة لأنها
+
+37
+00:03:21,300 --> 00:03:25,380
+الحرف التالت ماله، الحرف التالت مضمون ضما عارضا
+
+38
+00:03:25,380 --> 00:03:29,080
+يعني ليس أصليا وإنما الأصل أن تكون مكسورة لكنها
+
+39
+00:03:29,080 --> 00:03:34,000
+وضعت الضم حتى تتناسب مع حرف الواو الذي جاء بعدها
+
+40
+00:03:34,500 --> 00:03:39,080
+طيب هذا بالنسبة للأفعال طيب بالنسبة للأسماء متى
+
+41
+00:03:39,080 --> 00:03:45,620
+تكون همزة الوصل في الأسماء؟ في حالتين أما سماعي و
+
+42
+00:03:45,620 --> 00:03:51,340
+أما قياسي القياسي إذا كان مصدر القماسي أو السلاسي
+
+43
+00:03:51,340 --> 00:03:58,300
+مثال ذلك انطلاقأو السلاسي استغفار استكبار يعني
+
+44
+00:03:58,300 --> 00:04:02,460
+مصدر الخماسي والسلاسي همزة و همزة واصل كذلك
+
+45
+00:04:02,460 --> 00:04:07,660
+بالنسبة للسمعية عندنا سبعة كلمات ما هي الكلمات
+
+46
+00:04:07,660 --> 00:04:12,360
+السابعة التي سمعت عن طريق العرب و همزة و همزة واصل
+
+47
+00:04:12,360 --> 00:04:20,700
+فضل الأخت ابن و ابنة و امرأ و امرأةواثنان واثنتان
+
+48
+00:04:20,700 --> 00:04:24,560
+واسم سبعة كلمات همزة وهمزة واصل طيب ما هي حركة
+
+49
+00:04:24,560 --> 00:04:29,080
+همزة الواصل اللي في الأسماء دايما مكسورة يعني مافي
+
+50
+00:04:29,080 --> 00:04:34,820
+همزة واصل حركتها مضمومة مثل ادعو ولا مكسورة مثل
+
+51
+00:04:34,820 --> 00:04:41,750
+اقترب او اضربوإنما كلها بتكون مكسورة ابن هي مكسورة
+
+52
+00:04:41,750 --> 00:04:47,950
+ابن مكسورة امرأة امرأ اثنان اثنتان اسم كله حمص
+
+53
+00:04:47,950 --> 00:04:52,310
+الوصل لما نبدأ بها طيب إذا كان وصلة حمص الوصل بما
+
+54
+00:04:52,310 --> 00:04:58,560
+قبلها؟ماذا نفعل؟ تسقط همزة الوصل يعني بتكون غير
+
+55
+00:04:58,560 --> 00:05:02,960
+معروفة هل هي مكسورة ولا مضمومة مثال ذلك كلمة اضرب
+
+56
+00:05:02,960 --> 00:05:08,580
+لو وصلناها بما قبلها قلنا يعني قلنا ضرب او وضرب
+
+57
+00:05:08,580 --> 00:05:12,920
+لهم مثلا إذا تسقط همزة الوصل الآن أنهينا يا أخوات
+
+58
+00:05:12,920 --> 00:05:16,780
+همزة الوصل في الأفعال و همزة الوصل في الأسماء طيب
+
+59
+00:05:16,780 --> 00:05:19,960
+همزة الوصل في الحروف ما هي الحروف اللي همزتها همزة
+
+60
+00:05:19,960 --> 00:05:25,680
+وصل؟فضليه همزته همزته ايه بس فقل التعريف يعني ليست
+
+61
+00:05:25,680 --> 00:05:29,740
+مثلا في الى او اليا ولا كده وانما بس قل التعريف
+
+62
+00:05:29,740 --> 00:05:38,500
+همزته همزة وصل مثل الله الملك القدوس السلام المؤمن
+
+63
+00:05:38,500 --> 00:05:43,740
+المهيمن هدي همزته همزة وصل اي التعريف همزته همزة
+
+64
+00:05:43,740 --> 00:05:50,750
+وصل طيب حركة همزة وصلحركة همزة الوصل بتكون مفتوحة
+
+65
+00:05:50,750 --> 00:05:56,430
+عند اقتدابها يعني نقول الله لا نقول الله ولا الله
+
+66
+00:05:56,430 --> 00:06:03,650
+الله الملك القدوس لكننا لو وصلناها بما قبلها تسقط
+
+67
+00:06:03,650 --> 00:06:10,940
+همزة الوصل يعني نقول ايه والله والملكواسم كذا فإذا
+
+68
+00:06:10,940 --> 00:06:15,220
+كل الهمزة .. همزة الواصل اللي في القلة التعريف
+
+69
+00:06:15,220 --> 00:06:19,920
+بتصفط همزة الواصل إذا وصلناها بما قبلها و تثبت إذا
+
+70
+00:06:19,920 --> 00:06:23,580
+ابتدأنا بها الكلام و بتكون همزة الواصل في الأسماء
+
+71
+00:06:23,580 --> 00:06:27,740
+مكسورة و في الأفعال مضمومة أو مفتوحة أما في الحروف
+
+72
+00:06:27,740 --> 00:06:32,220
+فهي تكون مفتوحة الآن في عندنا يا أخوات عدة ملاحظات
+
+73
+00:06:32,220 --> 00:06:37,370
+أو عدة فوائد الفائد الأولى هنا مثلاتحدث مثل الوصل
+
+74
+00:06:37,370 --> 00:06:42,550
+لفظا و خطا من قلة التعريف إذا دخلت عليها لام الجر
+
+75
+00:06:42,550 --> 00:06:47,810
+يعني مثلا لو أي كلمة مبدوعة بقلة التعريف لو دخلنا
+
+76
+00:06:47,810 --> 00:06:54,450
+عليها حرف جر غير اللاميعني مثلا نقول مثلا المتقين
+
+77
+00:06:54,450 --> 00:07:00,970
+المدرسة الملك دخلنا عليها مثلا حرف من من المتقين
+
+78
+00:07:00,970 --> 00:07:07,150
+على المتقين إلى المتقين لكن لو دخلنا عليها حرف
+
+79
+00:07:07,150 --> 00:07:15,360
+الجر تسقط همزة الوصل فنقول للمتقينللملك .. للمدرسة
+
+80
+00:07:15,360 --> 00:07:19,780
+.. و هكذا بتصلت فهمسة الوصل يبقى تحدث فهمسة الوصل
+
+81
+00:07:19,780 --> 00:07:25,380
+لفظا و خطا من قلة تعريف إذا دخلت عليها لام الجر
+
+82
+00:07:25,380 --> 00:07:30,260
+كويس؟ لكن أي حرف غير لام الجر لو دخلت على قلة
+
+83
+00:07:30,260 --> 00:07:34,050
+تعريفلا .. لا تسقط حمزة الوصل تبقى كما هي لكن فقط
+
+84
+00:07:34,050 --> 00:07:37,450
+في حمزة الوصل اللي .. في أقل التعريف لو دخلت عليها
+
+85
+00:07:37,450 --> 00:07:44,230
+لام زي مثلا للمتقين تحدث حمزة الوصل لفظا و خطا مثل
+
+86
+00:07:44,230 --> 00:07:51,960
+هذه ان للمتقين مفازا لا نقول لالمتقينيعني لو دخلنا
+
+87
+00:07:51,960 --> 00:07:58,600
+عليها من المتقين نقول من المتقين إلى المتقين عن
+
+88
+00:07:58,600 --> 00:08:04,400
+المتقين نرفض ال ال لكن هذه اللام للمتقين وتسقط
+
+89
+00:08:04,400 --> 00:08:10,360
+الهمزة الوصل لفظا و خطا فنقول للمتقين كذلك كلمة
+
+90
+00:08:10,360 --> 00:08:17,440
+الذين للذين أحسنوا الحسن وزيادةلنقول هي أصلا
+
+91
+00:08:17,440 --> 00:08:21,280
+الاذينة دخلت عليها لام التعريف فصارت الأصل
+
+92
+00:08:21,280 --> 00:08:27,200
+لالاذينة لكنها حسب القاعدة تسقط همس الوصل لفظا
+
+93
+00:08:27,200 --> 00:08:33,700
+وخطا فنقرأها للمتقين وهكذا في كل قلة تعريف اللي
+
+94
+00:08:33,700 --> 00:08:39,590
+بتدخل عليها همسة أو لام الجرإذا دخلت عليها مثلا
+
+95
+00:08:39,590 --> 00:08:45,530
+الذين يؤمنون بالغيب نقول بالغيب اللي التعريف دخلت
+
+96
+00:08:45,530 --> 00:08:52,650
+عليها حرف اللام تقرأ بالغيب هنا بالآخرة وبالآخرة
+
+97
+00:08:52,650 --> 00:08:59,390
+لفظناها تلفظ وبالآخرة كذلك لهم البشرة في الحياة
+
+98
+00:08:59,390 --> 00:09:04,800
+الدنيايعني بتدالها ثابتة خطا .. ثابتة خطا اللي هي
+
+99
+00:09:04,800 --> 00:09:10,000
+همزة الوصل لكنها طبعا تسقط من حيث اللفظة تسقط لفظا
+
+100
+00:09:10,000 --> 00:09:17,260
+و تثبت خطا لكن لو وضعنا بدلا من حرف الف لا .. لا
+
+101
+00:09:17,260 --> 00:09:22,880
+يعني تسقط الهمزة لفظا و خطا فنقول للحياة الدنيا
+
+102
+00:09:24,470 --> 00:09:29,870
+للآخرة بالغيب يصير للغيب بتسقط حمص الوصل لفظا و
+
+103
+00:09:29,870 --> 00:09:33,830
+خطا هذه الفائدة الأولى ما هي الفائدة الأولى يا
+
+104
+00:09:33,830 --> 00:09:40,610
+أخوات فضلي قال
+
+105
+00:09:40,610 --> 00:09:48,150
+التعريف تسقط حمص الوصلممتاز يعني إذا دخلت الام
+
+106
+00:09:48,150 --> 00:09:54,210
+الجر على أي اسم مبدوء بقل التعريف تسقط همس الوصل
+
+107
+00:09:54,210 --> 00:10:00,230
+لفظا و خطا بينما لو وضع قبل هذا الاسم المبدوء بقل
+
+108
+00:10:00,230 --> 00:10:05,250
+التعريف أي حرف من حروف الجر يعني يثبتوا قل التعريف
+
+109
+00:10:05,250 --> 00:10:11,590
+لفظا و تسقطوا .. لفظا تسقط و تبقى خطا عندنا
+
+110
+00:10:11,590 --> 00:10:15,790
+الفائدة الثانية يا أخواتوهو إذا دخلت همزة
+
+111
+00:10:15,790 --> 00:10:19,810
+الاستفهام على الأسماء المعرفة ب L يعني في عندنا
+
+112
+00:10:19,810 --> 00:10:24,770
+اسم معرف ب L دخلت عليه همزة الاستفهام إيش بيصير؟
+
+113
+00:10:24,770 --> 00:10:28,670
+طبقة همزة الوصل اللي هي تحت L التعريف ولا تحذف ال
+
+114
+00:10:28,670 --> 00:10:33,450
+L ليلتبس الاستفهام بالخبر فيتغير المعنى ولم يقع
+
+115
+00:10:33,450 --> 00:10:38,770
+منه في القرآن إلا في ثلاثة مواضع ومكررة بس كل
+
+116
+00:10:38,770 --> 00:10:42,130
+مواضع كررة مرتين مثال ذلك قل
+
+117
+00:10:47,750 --> 00:10:55,630
+الذكرين هي أصلها الذكرينالذكر والأنثى الذكرين لأن
+
+118
+00:10:55,630 --> 00:11:00,450
+الكفار كانوا يحرموا بعض الحيوانات على أنفسهم فربنا
+
+119
+00:11:00,450 --> 00:11:03,770
+سبحانه وتعالى يقول من باب الاستفهام الإنكارى قل
+
+120
+00:11:03,770 --> 00:11:11,130
+الذكرين حرم أم الأنثى فهنا الذكرين دخلت عليها همزة
+
+121
+00:11:11,130 --> 00:11:14,310
+الاستفهام وهمزة الاستفهام هنا يا أخوات همزة
+
+122
+00:11:14,310 --> 00:11:19,330
+استفهام إنكارىيعني هي الأصل أن تقرأ أذ ذكرين حرم
+
+123
+00:11:19,330 --> 00:11:23,730
+أم الأنثيين لكنها حسب القاعدة إذا دخلت همثل
+
+124
+00:11:23,730 --> 00:11:28,970
+استفهامعلى الإسم المعرف ب L اللي هو الذكرين إيش
+
+125
+00:11:28,970 --> 00:11:33,830
+بيصير؟ تبقى همزة الاستفهام ولا تسقط الأصل أن تسقط
+
+126
+00:11:33,830 --> 00:11:38,730
+لكنها لو سقطت همزة الاستفهام تبقى كما هي لأن همزة
+
+127
+00:11:38,730 --> 00:11:44,510
+الاستفهام مفتوحة و همزة الاسم ال L التعريف برضه
+
+128
+00:11:44,510 --> 00:11:50,230
+مفتوحة لو سقطت همزة الوصل تبقى كما هي همزة
+
+129
+00:11:50,230 --> 00:11:54,160
+الاستفهام تقرأ نفس الشيءيعني لو في عندنا الذكرين
+
+130
+00:11:54,160 --> 00:11:58,960
+دخلنا عليها همزة سقطت همزة للوسط تقرأ الذكرين فحتى
+
+131
+00:11:58,960 --> 00:12:03,780
+لا تقرأ الذكرين ولأن هنا فيه التباسإيش القاعدة
+
+132
+00:12:03,780 --> 00:12:08,100
+بتقول لو دخلت همزة الاستفهام على الاسم المعرف بال
+
+133
+00:12:08,100 --> 00:12:12,360
+يعني الذكرين دخلنا عليها همزة الاستفهام همزة
+
+134
+00:12:12,360 --> 00:12:17,100
+الواصل بتاعة الذكرين لا تسقط بل تبقى كما هي و تبدأ
+
+135
+00:12:17,100 --> 00:12:21,580
+بحرف مد و من مده ست حركات و من سمي مد الفرق و
+
+136
+00:12:21,580 --> 00:12:26,300
+نقرأها فنقول الذكرين
+
+137
+00:12:27,260 --> 00:12:32,180
+وهي يسمى مادة الفرق هو نفسه .. نفسه لأنها أذاكرين
+
+138
+00:12:32,180 --> 00:12:35,920
+طبعا اللام بتتغم مع الذال اللام اللام اللام اللام
+
+139
+00:12:35,920 --> 00:12:39,080
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+140
+00:12:39,080 --> 00:12:39,080
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+141
+00:12:39,080 --> 00:12:39,380
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+142
+00:12:39,380 --> 00:12:39,640
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+143
+00:12:39,640 --> 00:12:39,640
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+144
+00:12:39,640 --> 00:12:40,080
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+145
+00:12:40,080 --> 00:12:42,660
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+146
+00:12:42,660 --> 00:12:42,660
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+147
+00:12:42,660 --> 00:12:44,320
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+148
+00:12:44,320 --> 00:12:46,760
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+149
+00:12:46,760 --> 00:12:53,900
+اللام اللام اللام اللام اللام اللام اللام
+
+150
+00:12:53,900 --> 00:12:57,620
+اللامو نمده ست حركات و في نفس الموضوع أثناء اللفظ
+
+151
+00:12:57,620 --> 00:13:02,500
+يمده كبذلك اللي هو مد اللازم الكلمي المثقل لأنه
+
+152
+00:13:02,500 --> 00:13:07,600
+جاء حرف المد ا و اللفظ اللي ماذا اضغمه فصارت
+
+153
+00:13:07,600 --> 00:13:10,980
+الذكرين
+
+154
+00:13:10,980 --> 00:13:14,920
+حرم أم الأنثين لكن القاعدة اللي بدنا نيهيها ..
+
+155
+00:13:14,920 --> 00:13:20,780
+يعني فيها تلت أحكام مع بعض أول شيء الاسم المعرف
+
+156
+00:13:20,780 --> 00:13:27,130
+بأهل الذكريندخلت عليه همس ال sfmلم تسقط همزة
+
+157
+00:13:27,130 --> 00:13:31,930
+الواصل بتاعة الذكرين لأنها هي مفتوحة و همزة الواصل
+
+158
+00:13:31,930 --> 00:13:35,050
+مفتوحة لو سقطت .. او همزة الاستفام مفتوحة و همزة
+
+159
+00:13:35,050 --> 00:13:39,490
+الواصل مفتوحة لو سقطت همزة الواصل للي تبس الأمر مش
+
+160
+00:13:39,490 --> 00:13:42,850
+عارفين إنه همزة الواصل ولا همزة الاستفام فلأنه في
+
+161
+00:13:42,850 --> 00:13:46,630
+عندنا لبس في الموضوع ماذا تحدث تبقى همزة الواصل
+
+162
+00:13:46,630 --> 00:13:51,390
+بتاعة الذكرين و تبدأ بحرف مدء و من مده ست حركات و
+
+163
+00:13:51,390 --> 00:13:53,810
+من سمية مده الفرق فنقول قل
+
+164
+00:13:58,670 --> 00:14:05,650
+من يقراها يا أخوات مع مادها ست حركات؟ فضل أخت
+
+165
+00:14:11,870 --> 00:14:16,290
+جزاك الله خير طبعا هذه كلمة احنا قولنا كام كلمة هي
+
+166
+00:14:16,290 --> 00:14:21,510
+تلات كلمات الكلمة الأولى أ ذكرين الكلمة الثانية
+
+167
+00:14:21,510 --> 00:14:27,270
+الان والكلمة التالتة اللهو كل واحدة كررت مرتين
+
+168
+00:14:27,270 --> 00:14:31,550
+يعني تلات كلمات في القرآن كله دخلت همزة الاستفامة
+
+169
+00:14:31,550 --> 00:14:35,250
+على اسم المعرف بال بقيت همزة الواصلة بتاعة ال
+
+170
+00:14:35,250 --> 00:14:39,670
+التعريف و أبدلت بحرف مد و مدناها ست حركات الكلمة
+
+171
+00:14:39,670 --> 00:14:49,140
+التانية اللي هي هذهالان وقد كنتم به تستعجلون ايش
+
+172
+00:14:49,140 --> 00:14:54,600
+اللي حصل فيها يا أخوات؟ نجد ان كلمة الان الان اللي
+
+173
+00:14:54,600 --> 00:14:59,820
+هو ظرف دخلت عليها مثل استفهام فالاصل ان تقرأ الان
+
+174
+00:15:00,580 --> 00:15:05,560
+لكن عارفين أنه الآن الهمزة همزة واصل الاصل أنت حدف
+
+175
+00:15:05,560 --> 00:15:10,480
+لكنها لو حدفت التبس علينا الموضوع اختلفت التبس
+
+176
+00:15:10,480 --> 00:15:16,220
+لأنه همزة الاستفهام بتحل محل همزة الواصل فتبقى
+
+177
+00:15:16,220 --> 00:15:21,530
+الآن لم يختلف شيءفحتى يأمن أمن اللبس تبقى همزة
+
+178
+00:15:21,530 --> 00:15:27,210
+الواصل وتبدأ بحرف مد اللي هو مد مقدار ست حركات
+
+179
+00:15:27,210 --> 00:15:31,150
+ومسمى مادة الفرق اسمناها الفرق حتى نفرق ما بين
+
+180
+00:15:31,150 --> 00:15:34,390
+همزة الاستفام و همزة الخبرعشان نقول إن هذه
+
+181
+00:15:34,390 --> 00:15:37,850
+الأولانية المفتوحة هي همزة الاصفام والتانية هي
+
+182
+00:15:37,850 --> 00:15:42,310
+همزة الواصل اللي بدلناها بحرف مده مدناها ست حركات
+
+183
+00:15:42,310 --> 00:15:47,210
+فنقرأها الان
+
+184
+00:15:47,210 --> 00:15:52,130
+وقد كنتم به تستعجلون والقراءة الثانية اللي هي
+
+185
+00:15:52,130 --> 00:15:56,070
+الآية الثانية الان
+
+186
+00:15:56,070 --> 00:16:01,530
+وقد عصيت قبل وكنت من المفسدينأيها أكام كلمة أنا
+
+187
+00:16:01,530 --> 00:16:05,870
+عندها؟ أخدنا كلمتين الكلمة التالتة يا أخوات اللي
+
+188
+00:16:05,870 --> 00:16:12,380
+هي قوله الله أصلا هي اللهودخلت عليه همسة الاصفام
+
+189
+00:16:12,380 --> 00:16:19,140
+فصارت أ الله لكن همسة الوصل يعني تسقط إذا وصلت بما
+
+190
+00:16:19,140 --> 00:16:23,040
+قبلها همسة الوصل بتاعة قلة تعنيف تسقط لو وصلت بما
+
+191
+00:16:23,040 --> 00:16:27,300
+قبلها فحد .. لو سقطت لو تبسعناينا الموضوع فإيش
+
+192
+00:16:27,300 --> 00:16:32,360
+بنعمل همسة الوصل تبقى و تبدأ بحرف مد و بنمده ست
+
+193
+00:16:32,360 --> 00:16:35,000
+حركات و بنقراها قل أ
+
+194
+00:16:40,090 --> 00:16:48,170
+ما نلخص القاعدة إذا دخلتهمزة الاستفهام على الإسم
+
+195
+00:16:48,170 --> 00:16:53,990
+المعرف ب L تبقى همزة الواصل تحت L التعليف وتبدأ
+
+196
+00:16:53,990 --> 00:16:58,850
+بحرف مده ومن مده 6 حركات ومن سمي مده الفرق حتى
+
+197
+00:16:58,850 --> 00:17:04,170
+نفرق ما بينها همزة الاستفهام وهمزة الواصل اللي هي
+
+198
+00:17:04,170 --> 00:17:10,270
+همزة الخبرة هذه القاعدة الثانية لابد أن نعرفهاطبعا
+
+199
+00:17:10,270 --> 00:17:13,770
+حكم ال .. ال .. المد أو القراءة بهذا ال .. بهذا
+
+200
+00:17:13,770 --> 00:17:18,710
+الوجه إما أن نموذها ست حركات و بنسميها مد الفرق أو
+
+201
+00:17:18,710 --> 00:17:23,890
+ممكن تسميها مد .. لازم كلمة مخفف في الأ أ الآن أو
+
+202
+00:17:23,890 --> 00:17:30,990
+مثقل في الله أذن لكم أو قل أذكريني تصير مد .. يعني
+
+203
+00:17:30,990 --> 00:17:35,610
+مد لازم كلمة مثقل لأ و كذلك تقرأ بالتسهيل يعني
+
+204
+00:17:35,610 --> 00:17:40,020
+بتسهيل همسة الوصل اللي إحنا قلناها ست حركاتنقراها
+
+205
+00:17:40,020 --> 00:17:45,500
+بتسهيل همس الوصل و من مدها جداش .. مش مد فيها تقرا
+
+206
+00:17:45,500 --> 00:17:51,050
+همس الوصل ما بين الهمزة والألفيعني ال A بتقول فان
+
+207
+00:17:51,050 --> 00:17:55,890
+زي ما هي الله أذن لكم، الذكرين حرم أم الأنتين،
+
+208
+00:17:55,890 --> 00:18:00,850
+الهمزة بتقول أ ولكن الهمزة الواصل يعني تقرأ
+
+209
+00:18:00,850 --> 00:18:06,090
+بالتسهيل لا هي همزة ولا هي حرف مد و بنقراها بتسهيل
+
+210
+00:18:06,090 --> 00:18:10,590
+همزة الواصل ما بين .. ما بين الهمزة والألف
+
+211
+00:18:12,710 --> 00:18:16,670
+في عندنا يا أخوات أيضا الفائدة التالتة تقول إذا
+
+212
+00:18:16,670 --> 00:18:20,510
+دخلت همزة الاستفهام على الأفعال المبدوعة بهمزة وصل
+
+213
+00:18:20,510 --> 00:18:26,190
+همزة الاستفهام دخلت على الفعل المبدوع بهمزة وصل
+
+214
+00:18:26,190 --> 00:18:31,690
+يعني في عندنا فعل مبدوع بهمزة وصل مثل مثلا اتخذ
+
+215
+00:18:31,690 --> 00:18:38,050
+اتخذ استغفر استكبر مثلا هذه فعل مبدوع بهمزة وصل
+
+216
+00:18:38,690 --> 00:18:44,390
+دخلت عليه همزة الاستفهام ايش بيصير عندنا لما كان
+
+217
+00:18:44,390 --> 00:18:51,830
+الفعل استغفر و استكبر و اتخذ الهمزة الوصل مكسورة و
+
+218
+00:18:51,830 --> 00:18:56,810
+همزة الاستفهام مفتوحة اذا اللابس ماله مأمون عند
+
+219
+00:18:56,810 --> 00:19:01,950
+اذن تحدث همزة الوصل و تبقى همزة الاستفهام نشوف هنا
+
+220
+00:19:01,950 --> 00:19:05,270
+القاعدةإذا دخلت همزة الاستفهام على الأفعال
+
+221
+00:19:05,270 --> 00:19:09,110
+المبدوعة بهمزة وصل مكسورة مثل اتخذة أو استغفرة
+
+222
+00:19:09,110 --> 00:19:13,510
+تحدث همزة الوصل لعدم اللابس ليس لأنها لابس فيها
+
+223
+00:19:13,510 --> 00:19:17,390
+لأن همزة الوصل في الأفعال مكسورة و همزة الاستفهام
+
+224
+00:19:17,390 --> 00:19:22,810
+مفتوحة فإذا حُدفت همزة الوصل وبتدرية بهمزة مفتوحة
+
+225
+00:19:22,810 --> 00:19:25,950
+اللي هي همزة الاستفهام علمة أنها همزة الاستفهام
+
+226
+00:19:25,950 --> 00:19:30,470
+والأمثل على ذلك كثيرة ومتعددةمن ضمنها .. من ضمنها
+
+227
+00:19:30,470 --> 00:19:34,530
+.. اللي هو إيش؟ الأنثى لعلى ذلك متعددة وكثيرة من
+
+228
+00:19:34,530 --> 00:19:40,030
+ضمنها قوله تعالى قل أتخذتم عند الله عهدة أتخذتم
+
+229
+00:19:40,030 --> 00:19:45,270
+عند الله عهدة أصلها اتخذة أصلها اتخذة همزة همزة
+
+230
+00:19:45,270 --> 00:19:51,450
+وصل طب لماذا همزة وصل هنا اتخذة ماضي الايه؟ماضي
+
+231
+00:19:51,450 --> 00:19:55,650
+الخماسي ماضي الخماسي همزة همزة واصل و الهمزة
+
+232
+00:19:55,650 --> 00:19:59,990
+مكسورة الأصل اتخذة مكسورة فدخلت عليها همسة
+
+233
+00:19:59,990 --> 00:20:06,330
+الاستفهام فالأصل أن تقرأ ا اتخذة لكن لما كانت حرف
+
+234
+00:20:06,330 --> 00:20:11,690
+الهمزة في اتخذة اللي هو ماضي الخماسي مكسور ابتسفت
+
+235
+00:20:11,690 --> 00:20:15,650
+همسة الواصل لأن الحرف الساكن اعتمد على همسة الواصل
+
+236
+00:20:15,650 --> 00:20:20,540
+ف .. و تبقى همسة الواصل كما هي فتقرأ اتخذةعلى أساس
+
+237
+00:20:20,540 --> 00:20:24,480
+إن همزة الوصل مكسورة لذلك مأمون اللبس فالقاعدة
+
+238
+00:20:24,480 --> 00:20:28,360
+اللي عندنا إذا دخلت همزة الاستفهام على الفعل
+
+239
+00:20:28,360 --> 00:20:33,860
+المبدو بهمزة وصل مكسورة بيسقط همزة الوصل و تبقى
+
+240
+00:20:33,860 --> 00:20:38,180
+همزة الاستفهام لأمن اللبس لأن اللبس مأمون لأن همزة
+
+241
+00:20:38,180 --> 00:20:42,200
+الاستفهام مفتوحة و همزة الوصل مكسورة بتسقط همزة
+
+242
+00:20:42,200 --> 00:20:46,760
+الوصل و تبقى همزة الاستفهام وبيفهم منها إن هذا إيش
+
+243
+00:20:46,760 --> 00:20:51,130
+هذه همزة الاستفهام مثل اتخذةدخل عليه همزة
+
+244
+00:20:51,130 --> 00:20:55,570
+الاستفهام فصارت ااتخذة لكن بتسقط همزة الوصل فبتصير
+
+245
+00:20:55,570 --> 00:21:00,870
+اتخذة قل اتخذتم عند الله عهدة الاستفهام هنا
+
+246
+00:21:00,870 --> 00:21:06,130
+استفهام قل اتخذتم عند الله عهدة فهنا السؤال كذلك
+
+247
+00:21:06,130 --> 00:21:11,810
+الطلعة الطلعة برضه ماضي الخماسي الطلعة همزة و همزة
+
+248
+00:21:11,810 --> 00:21:15,870
+ايش يا اخوات همزة واصل مكسورةدخلت عليه همسة
+
+249
+00:21:15,870 --> 00:21:22,750
+الاستفهام فصارت ا اطلعة لكن ا اطلعت الهمزة واصل
+
+250
+00:21:22,750 --> 00:21:25,870
+ايش بيصير في الهمزة اللي واصل لما توصل بما قبلها؟
+
+251
+00:21:26,870 --> 00:21:31,210
+إف تسقط فلمّا سقطت حمزة الوصل و بقيت هذه الكلمة
+
+252
+00:21:31,210 --> 00:21:35,770
+اللي هو حمزة الاستفهام فبتقرأ اطلع الغيب يعني اطلع
+
+253
+00:21:35,770 --> 00:21:39,470
+الغيبة نظرة إلى الغيب فالاستفهام هنا استفهام
+
+254
+00:21:39,470 --> 00:21:44,930
+انكاري اطلع الغيبة ام يتخدعي نضر رحماني عهده كذلك
+
+255
+00:21:44,930 --> 00:21:50,770
+كلمة افطرة افطرة أيضا ماضي الخماسي مبدو بحمزة وصل
+
+256
+00:21:50,770 --> 00:21:57,520
+مالهامكسورة، مش هيك؟ دخلت علي همس الاستفهام، أفطر،
+
+257
+00:21:57,520 --> 00:22:03,440
+لكن همس الوصل ابتحذف، ابتحذف على أساس أنه هي وصلت
+
+258
+00:22:03,440 --> 00:22:08,540
+بما قبلها و يبقى همس الاستفهام، فإيش نجراها؟ أفطر،
+
+259
+00:22:08,540 --> 00:22:11,280
+مين يجرا ليها؟ فضلي
+
+260
+00:22:15,790 --> 00:22:21,610
+أفترى على الله كذبا كذلك أطلع الغيب هنا قل أتخذتم
+
+261
+00:22:21,610 --> 00:22:26,390
+عند الله عهدة هنا أصطفى نفس الموضوع أصطفى دخلت
+
+262
+00:22:26,390 --> 00:22:30,610
+عليه همسة الاستفام فصارت أصطفى لكن همسة الوصل
+
+263
+00:22:30,610 --> 00:22:35,450
+ابتسقط فبتقرأ فقط أصطفى البنات على البنين و هكذا
+
+264
+00:22:35,450 --> 00:22:41,510
+كذلك السداسية مثلاأستكبرت أم كنت من العالين؟ أصلا
+
+265
+00:22:41,510 --> 00:22:49,010
+استكبرت دخلت عليها همزة الاستفهام فصارت أستكبرت
+
+266
+00:22:49,010 --> 00:22:54,450
+لكن تسفط همزة الواصل بتاعة استكبرة فبتقرأ تلقائي
+
+267
+00:22:54,450 --> 00:22:58,770
+أستكبرت يعني أستكبرت اللي هي استفهام يعني إنكاري
+
+268
+00:22:59,880 --> 00:23:04,640
+كذلك أستغفرت لهم سواء عليهم أستغفرت لهم أم لم
+
+269
+00:23:04,640 --> 00:23:11,000
+تستغفر لهم أستغفرت مفهومة أنه مش استغفرت استغفرت
+
+270
+00:23:11,000 --> 00:23:15,340
+مكسورة همست الوصل لكن دخلت علي همست الاستفان فصالة
+
+271
+00:23:15,340 --> 00:23:21,190
+أستغفرت سقطت همست الوصلوباقية همزة الاستفاف ومن
+
+272
+00:23:21,190 --> 00:23:26,070
+الفظها لأنه مأمون النفس فنقول أستغفرت لهم أم لم
+
+273
+00:23:26,070 --> 00:23:31,530
+تستغفر لهم هذه هي الملاحظة أو الفائدة الثالثة
+
+274
+00:23:31,530 --> 00:23:37,190
+الفائدة الرابعة أيضا تقول إذا تقدمت همزة الوصل على
+
+275
+00:23:37,190 --> 00:23:43,390
+همزة القطع مثل اؤتمناتقدمت همزة يعني في عيننا
+
+276
+00:23:43,390 --> 00:23:49,630
+همزتين همزة وصل الأولى همزة وصل والثانية همزة تغطى
+
+277
+00:23:49,630 --> 00:23:54,970
+يعني الفعل الفعل فيه همزتين الهمزة الأولى همزة وصل
+
+278
+00:23:55,740 --> 00:23:59,180
+والهمزة الثانية اللي هو الحرف الثاني الساكن همزة
+
+279
+00:23:59,180 --> 00:24:02,960
+قطع فالقاعدة بتقول إذا تقدمت همزة الوصل على الهمزة
+
+280
+00:24:02,960 --> 00:24:09,800
+القطع فإذا وصلناها تحدث همزة الوصل مثال ذلك نقول
+
+281
+00:24:09,800 --> 00:24:16,120
+فليؤد اللذي أتمن أمانتهمفليؤد الذي أُقت منه فليا
+
+282
+00:24:16,120 --> 00:24:20,920
+نوصلها مع الهمزة تاعة الواو فليؤد الذي أُقت من
+
+283
+00:24:20,920 --> 00:24:25,740
+أمانتهم هي أصلا أُقت منها أصلا الكلمة أُقت منها
+
+284
+00:24:25,740 --> 00:24:34,430
+لكن لو وصلناهابتحذف همزة الوصل هذه أؤتمنى وتقرأ
+
+285
+00:24:34,430 --> 00:24:38,410
+الذي أؤتمنى يعني اللي يقمع الواو اللي عليها همزة
+
+286
+00:24:38,410 --> 00:24:44,610
+كذلك هنا ومنهم يقول ائذن ليه يقولوا ائذن ليه الواو
+
+287
+00:24:44,610 --> 00:24:48,670
+اللام وراها الهمزة مباشرة هي أصلا عندنا همزتين
+
+288
+00:24:48,670 --> 00:24:53,640
+الهمزة الأولى همزة وصلوالتانية همزة قطع اللي هي
+
+289
+00:24:53,640 --> 00:24:57,840
+همزة الكلمة الساكنة عندما نصلها مع بعضها لبعض
+
+290
+00:24:57,840 --> 00:25:02,580
+طبيعي جدا تسقط همزة الوصل ولكن إذا ابتدأنا بها
+
+291
+00:25:02,580 --> 00:25:07,340
+الكلام يعني وقفنا في باب الاختبار أو الإضطرار يعني
+
+292
+00:25:07,340 --> 00:25:12,620
+واحد مثلا جاعت بيقرأ فليؤدي الذي وقف عندهاو بده
+
+293
+00:25:12,620 --> 00:25:16,660
+يبدأ من باب الاختبار بس يعني اختبارا او اضطرارا
+
+294
+00:25:16,660 --> 00:25:22,120
+بده يقول اوتمن امانته او ايذا ليه بيصير ايذا ليه
+
+295
+00:25:22,120 --> 00:25:29,160
+هنا مثلا املهم شركهم في السماوات ايتوني بكتاب يعني
+
+296
+00:25:29,160 --> 00:25:34,120
+مثلا من باب الاختبار كيف يعني اختبار يعني المدرس
+
+297
+00:25:34,120 --> 00:25:38,750
+بده يختبر .. يختبر الطلابلو الطالب قرأ ام لهم
+
+298
+00:25:38,750 --> 00:25:43,870
+شيركم في السماوات اتوني بكتاب ممكن المدرس يقوله
+
+299
+00:25:43,870 --> 00:25:48,750
+طيب قف عند كلمة السماوات و ابدا من قوله اتوني كيف
+
+300
+00:25:48,750 --> 00:25:54,890
+تقراها اختبارا هيقراها اتوني بكتاب من قبل هذا
+
+301
+00:25:54,890 --> 00:25:59,710
+مفهوم يا أخوات؟ مثال و ذلك لتوضيح يعني اول شيء
+
+302
+00:25:59,710 --> 00:26:04,630
+اؤتمنا هذا هي اؤتمنا في عندنا همزتين الهمزة الأولى
+
+303
+00:26:04,630 --> 00:26:11,850
+همزة وصلوالثاني قطع لو جاء حسب القاعدة إذا جاء
+
+304
+00:26:11,850 --> 00:26:17,370
+همزتين في كلمة في الحرف الأول همزة توصل والثاني
+
+305
+00:26:17,370 --> 00:26:21,730
+همزة قطع تبدل الهمزة الثانية اللي هي همزة القطع
+
+306
+00:26:21,730 --> 00:26:28,220
+بحرف مد من جنس حركة الهمزة الأولىبتدأ بها من جنس
+
+307
+00:26:28,220 --> 00:26:31,220
+حركة الهمزة الأولى فلمّا كانت الهمزة الأولى في
+
+308
+00:26:31,220 --> 00:26:37,400
+قوله أُق تمنا مضمومة ليهمس الوصل ليش مضمومة؟ لأن
+
+309
+00:26:37,400 --> 00:26:44,520
+التو التاهنة مضموم فتضم همس الوصلفلمّا ليش نقرأها،
+
+310
+00:26:44,520 --> 00:26:48,660
+إيش بيصير؟ إذا جاءت همزة للهمز تاني و كانت الهمزة
+
+311
+00:26:48,660 --> 00:26:53,620
+الأولى مضمومة و الهمزة الثانية ساكنة، تبدر الهمزة
+
+312
+00:26:53,620 --> 00:26:59,040
+الثانية الساكنة بحرف مد من جنس حركة الهمزة الأولى،
+
+313
+00:26:59,040 --> 00:27:03,820
+إيش حركة الهمزة الأولى؟ضمها فبتصير الهمزة الثانية
+
+314
+00:27:03,820 --> 00:27:08,160
+wow لما نيجي نبداها كيف نبداها نقول او تمنا
+
+315
+00:27:08,160 --> 00:27:12,780
+أمانتها او تمنا عساس انه اللي هنا ال wow بتصير ال
+
+316
+00:27:12,780 --> 00:27:20,380
+.. الهمزة wow اقذني اقذني هي أصلا همزتين الهمزة
+
+317
+00:27:20,380 --> 00:27:24,420
+الأولى همزة واصلة مكسورة اقذن لإنها مفتوحة حرف
+
+318
+00:27:24,420 --> 00:27:30,350
+الذال مفتوح بتصير اقذني والذال مالهاو الهمزة
+
+319
+00:27:30,350 --> 00:27:35,330
+الثانية همزة ساكنة فتبدأ للهمزة الثانية الساكنة
+
+320
+00:27:35,330 --> 00:27:39,350
+بحرف مد من جنس حركة الهمزة الأولى ايش الهمزة
+
+321
+00:27:39,350 --> 00:27:43,650
+الأولى عليها هنا كسرة فبتصير الهمزة الثانية يا
+
+322
+00:27:43,650 --> 00:27:49,770
+عندما نقرأها أو نبدأ بها الكلام نقول evenlyكذلك
+
+323
+00:27:49,770 --> 00:27:55,390
+اقتوني هذه همزة الوصل، همزة الوصل مكسورة وهمزة
+
+324
+00:27:55,390 --> 00:28:00,270
+الكلمة اقتوني موجودة تبدأ الهمزة الثانية اللي هي
+
+325
+00:28:00,270 --> 00:28:05,050
+اقتوني بحرف مد من جنس حركة الهمزة الأولى، الهمزة
+
+326
+00:28:05,050 --> 00:28:08,990
+الأولى مكسورة فالهمزة الثانية بصياش ايتوني بكتاب
+
+327
+00:28:08,990 --> 00:28:13,730
+تقرأها كدهأيتوني بكتاب من قبل هذا هنا فليؤد اللذي
+
+328
+00:28:13,730 --> 00:28:17,990
+اقتمن أمانته في الواصل نقول فليؤد اللذي اقتمن
+
+329
+00:28:17,990 --> 00:28:22,910
+أمانته بتصير هكذا اللذي اقتمن في الواصل اللذي
+
+330
+00:28:22,910 --> 00:28:28,610
+اقتمن هنايقول اذن لي .. يقول اذن لي .. ثقت حمس
+
+331
+00:28:28,610 --> 00:28:33,970
+الوصل .. هنا في السماوات اتوني طب لو بدينا بيها
+
+332
+00:28:33,970 --> 00:28:40,230
+ايش بنبدأها؟ بنبدأها اي توني او او تومينة او اذن
+
+333
+00:28:40,230 --> 00:28:46,220
+لي .. هذه القاعدة الايه؟ القاعدة الرابعة؟وهو إذا
+
+334
+00:28:46,220 --> 00:28:51,920
+دخلت hamstring إستفام على الفعل المبدوء بهمزة ..
+
+335
+00:28:51,920 --> 00:28:54,180
+يعني إذا كان .. أحنا .. أحنا صار عندنا hamstring
+
+336
+00:28:54,180 --> 00:28:57,620
+مثلا ليه؟ إذا تقدمت hamstring الوصل عندنا
+
+337
+00:28:57,620 --> 00:29:00,800
+hamstring تقدمت hamstring الوصل على الhamstring
+
+338
+00:29:00,800 --> 00:29:03,600
+الثاني اللي هي hamstring القطع الأصلي في الكلمة
+
+339
+00:29:03,600 --> 00:29:08,420
+إيش بيصير؟ عند وصلها تسقط hamstring الوصلوعند
+
+340
+00:29:08,420 --> 00:29:13,100
+الابداء بها تبدأ الهمزة الثانية بحرف مد من جنس
+
+341
+00:29:13,100 --> 00:29:17,440
+حركة الهمزة الأولى زي ما ذكرنا الأمثلة أُتُمن
+
+342
+00:29:17,440 --> 00:29:22,900
+أمانته إيذنلي إيتوني بكتاب لو بدأنا بها لو وصلناها
+
+343
+00:29:22,900 --> 00:29:28,920
+فليؤد اللذؤتمن أمانته ومنهم يقول إيذنلي أملأ
+
+344
+00:29:28,920 --> 00:29:32,940
+مشيركم في السماوات إيتوني بكتاب نشوف يا أخوات
+
+345
+00:29:32,940 --> 00:29:38,400
+الملاحظة الخامسة أخر ملاحظة أو أخر فائدةوهو إذا
+
+346
+00:29:38,400 --> 00:29:43,360
+وقف القارئ على بئسة الاية بتقول بئسة لاسم الفسوق
+
+347
+00:29:43,360 --> 00:29:47,640
+بعد الإيمان بئسة لاسم الفسوق بعد الإيمان من باب
+
+348
+00:29:47,640 --> 00:29:53,480
+الاختبار او الاضطرار وقف القارئ على كلمة بئسة فكيف
+
+349
+00:29:53,480 --> 00:29:59,580
+نقرأ اسم الاسم نقراها الاسم ولا الاسم انشوف كيف
+
+350
+00:29:59,580 --> 00:30:05,140
+القاعدة بتقول إذا وقف القارئ على بئس اختبارا او
+
+351
+00:30:05,140 --> 00:30:10,840
+اضطراراو أراد أن يبدأ من كلمة الاسم الاسم الفسوق
+
+352
+00:30:10,840 --> 00:30:15,900
+بعد الإيمان هبتدأ بنفس الاسم يجوز له وجهين الوجه
+
+353
+00:30:15,900 --> 00:30:21,740
+الأول أن يقراها الاسم الاسم يعني يقرا بئس طب
+
+354
+00:30:21,740 --> 00:30:25,500
+بنقوله طب ابدأ من عند الاسم كيف تقراها بيقول الاسم
+
+355
+00:30:25,500 --> 00:30:30,610
+الفسوق بعد الإيمانوالوجه الثاني أن يقرأها لاسم
+
+356
+00:30:30,610 --> 00:30:35,050
+الفسوق و بعدين يجب أن يقرأها الاسم و يجب أن يقرأها
+
+357
+00:30:35,050 --> 00:30:40,730
+الاسم و كلاهما جائز و هذه قاعدة يبقى في عنا كام
+
+358
+00:30:40,730 --> 00:30:45,150
+قاعدة خمس قواعد أو خمس ملاحظات و خمس فوائد اللتي
+
+359
+00:30:45,150 --> 00:30:49,630
+ذكرناها فوائد مهمة في القراءة لابد أن تتطلع عليها
+
+360
+00:30:49,630 --> 00:30:52,270
+و تتعرف عليها و ان شاء الله ربنا يبوفز عليكم و
+
+361
+00:30:52,270 --> 00:30:54,850
+يبوفز عليكم نكتفي احنا بهذا القدر و نكمن ان شاء
+
+362
+00:30:54,850 --> 00:30:56,810
+الله في اللقاء القادم و السلام عليكم و رحمة الله
+
+363
+00:30:56,810 --> 00:30:57,980
+وبركاتهالسلام عليكم
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LB6B6Wfggz0.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LB6B6Wfggz0.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b69caa91d4a86bf7e4920699917bc201721b14d2
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LB6B6Wfggz0.srt
@@ -0,0 +1,1307 @@
+1
+00:00:11,360 --> 00:00:14,540
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:14,540 --> 00:00:19,520
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى 
+
+3
+00:00:19,520 --> 00:00:24,220
+آله وصحبه وسلم موضوعنا اليوم يا أخوات هو القطع
+
+4
+00:00:24,220 --> 00:00:30,790
+وهناك فرق بين القطع والوقف، ما معنى الوقف؟ ذكرناه 
+
+5
+00:00:30,790 --> 00:00:35,490
+سابقا؟ ما معنى الوقف الذي ذكرناه سابقا؟ هو قطع
+
+6
+00:00:35,490 --> 00:00:40,450
+الصوتي على الكلمة القرآنية زمنا يسيرا يتنفس فيه
+
+7
+00:00:40,450 --> 00:00:44,270
+القارئ عادة، بنية استئناف التلاوة لبنية الإعراض
+
+8
+00:00:44,270 --> 00:00:51,930
+عنها، مثل إيش؟ مثلا الحمد لله رب العالمين، أنا الآن
+
+9
+00:00:51,930 --> 00:00:59,560
+وقفت عشان أتنفس، الرحمن الرحيم هي كمان وقفة، مالك يوم
+
+10
+00:00:59,560 --> 00:01:04,480
+الدين هي كمان وقفة، طيب هذا وقفة، فما معنى القطع 
+
+11
+00:01:04,480 --> 00:01:10,500
+القطع من حيث اللغة الإزالة والإبانة، أقول قطعت
+
+12
+00:01:10,500 --> 00:01:16,230
+الشجرة بمعنى أزلتها، وفي الاصطلاح هو الانتهاء من
+
+13
+00:01:16,230 --> 00:01:20,870
+القراءة والانصراف عنها إلى أمر آخر لا علاقة له 
+
+14
+00:01:20,870 --> 00:01:26,470
+بالقراءة، كأن أكون قاعد بأقرأ، أنا قاعد بأقرأ ثم أنه
+
+15
+00:01:26,470 --> 00:01:31,290
+أنهي القراءة وأنشغل بأمر آخر، مثلا أن أقول الحمد
+
+16
+00:01:31,290 --> 00:01:35,190
+لله رب العالمين الرحمن الرحيم مالك يوم الدين صدق
+
+17
+00:01:35,190 --> 00:01:40,550
+الله العظيم وأمشي، أنا الآن أنهيت القراءة أو انصرف
+
+18
+00:01:40,550 --> 00:01:47,150
+عنها إلى أمر آخر، وكذلك عندما يقرأ في الصلاة يقرأ
+
+19
+00:01:47,150 --> 00:01:51,830
+القرآن، الفاتحة ثم ما تيسر له من القرآن ثم ينصرف عن 
+
+20
+00:01:51,830 --> 00:01:56,650
+القراءة وينشغل بأمر آخر وهو الرقوع، هذا أيضا اسمه 
+
+21
+00:01:56,650 --> 00:02:00,930
+الانتهاء من القراءة وانشغال عنها بأمر آخر وهو
+
+22
+00:02:00,930 --> 00:02:07,220
+الرقوع، إذا القطع من حيث اللغة الإزالة والإبانة، وفي 
+
+23
+00:02:07,220 --> 00:02:11,100
+الاصطلاح هو الانتهاء من القراءة وإنشغال عنها بأمر 
+
+24
+00:02:11,100 --> 00:02:16,430
+آخر لا علاقة له بالقراءة، ونحن عندما نقرأ القرآن 
+
+25
+00:02:16,430 --> 00:02:20,870
+هناك قطع، إذا أردنا نقطع القراءة وننشغل عنها بأمر 
+
+26
+00:02:20,870 --> 00:02:25,630
+آخر، في قطع جائز وقطع غير جائز، طبعا القطع الجائز
+
+27
+00:02:25,630 --> 00:02:29,790
+عندما تكون القراءة أو المعنى يعني استقر وأصبح
+
+28
+00:02:29,790 --> 00:02:34,330
+تامًا، ولا علاقة له بمبداه في اللفظ ولا معنى، أو له 
+
+29
+00:02:34,330 --> 00:02:38,550
+علاقة باللي بعده من حيث المعنى، لمن حيث اللفظ، كان
+
+30
+00:02:38,550 --> 00:02:42,450
+يكون أنا قطعت القراءة على وقف تام أو وقف كافٍ
+
+31
+00:02:42,450 --> 00:02:48,550
+والأمثلة على ذلك متعددة وهي كثيرة في القرآن، ونرى 
+
+32
+00:02:48,550 --> 00:02:54,570
+مثلًا، مثال على ذلك مثلًا إذا قرأ القارئ مثلًا
+
+33
+00:02:54,570 --> 00:02:58,990
+هنقول، روى أيضًا أو رواه البخاري ومسلم عن ابن
+
+34
+00:02:58,990 --> 00:03:03,310
+مسعود رضي الله عنه أنه قال، قال لي رسول الله صلى
+
+35
+00:03:03,310 --> 00:03:08,580
+الله عليه وسلم اقرأ عليّ، فقلت له عبد الله بن مسعود 
+
+36
+00:03:08,580 --> 00:03:13,620
+أقرأ عليك وعليك أنزل، قال إني أحب أن أسمعه من غيري
+
+37
+00:03:13,620 --> 00:03:19,000
+فافتتحت بصورة النساء، فلما بلغت قوله تعالى فكيف 
+
+38
+00:03:19,000 --> 00:03:24,140
+إذا جئنا من كل أمة بشهيد، وجئنا بك على هؤلاء شهيدة 
+
+39
+00:03:24,140 --> 00:03:28,740
+النبي عليه الصلاة والسلام كان يستمع فقال له حسبك،
+
+40
+00:03:28,740 --> 00:03:36,880
+يعني يكفيك، فنظرت إليه فإذا عينه تذرفان، فهنا القطع 
+
+41
+00:03:36,880 --> 00:03:41,420
+على قوله وجئنا بك على هؤلاء شهيدة، يعني تم المعنى
+
+42
+00:03:41,420 --> 00:03:47,920
+عنده، لكنه يتعلق بمبداه إيه في المعنى، لمن حيث اللفظ،
+
+43
+00:03:47,920 --> 00:03:52,400
+فهنا مثلا عندما وقف على قوله فكيف إذا جئنا من كل
+
+44
+00:03:52,400 --> 00:03:59,320
+أمة بشهيده وجئنا بك على هؤلاء شهيدة اللي هي في
+
+45
+00:03:59,320 --> 00:04:02,510
+سورة النساء، آية 41، قال النبي عليه الصلاة والسلام 
+
+46
+00:04:02,510 --> 00:04:06,990
+حسبك، فالوقف على كلمة حسبك أو على كلمة شهيدة اسم
+
+47
+00:04:06,990 --> 00:04:11,990
+وقف كافٍ، تم المعنى عنده، لكنه يتعلق بما بعده في
+
+48
+00:04:11,990 --> 00:04:16,190
+المعنى دون اللفظ، لأن ما بعده يومئذ يودوا الذين
+
+49
+00:04:16,190 --> 00:04:20,790
+كفروا وعصوا الرسول لو تسوى بهم الأرض ولا يكتمون
+
+50
+00:04:20,790 --> 00:04:25,050
+الله حديثا، الكلام لم ينتهي من حيث المعنى، لكنه من
+
+51
+00:04:25,050 --> 00:04:30,270
+حيث اللفظ انتهى، فالوقف عليه وقف إيه؟ وقف كافٍ، إذا 
+
+52
+00:04:30,270 --> 00:04:35,050
+بالنسبة للقطع طبعا القطع شرعًا يجوز ومن حيث الإصلاح
+
+53
+00:04:35,050 --> 00:04:39,030
+أيضًا جائز، وهو قطع الصوت على الكلمة القرآنية بحيث
+
+54
+00:04:39,030 --> 00:04:44,930
+يتم المعنى عندها أو له معنى، ولكنه ليس متعلق بما 
+
+55
+00:04:44,930 --> 00:04:49,770
+بعده من حيث اللفظ، له قسمين، القطع له قسمان أو ينقسم 
+
+56
+00:04:49,770 --> 00:04:53,330
+إلى قسمين، القسم الأول اللي هو القطع الجائز أو
+
+57
+00:04:53,330 --> 00:04:56,530
+القطع الحسن، نفس الشيء يعني القطع جائز، اللي هو القطع 
+
+58
+00:04:56,530 --> 00:05:00,530
+الحسن، والقطع غير جائز وهو القطع الذي نسميه القطع
+
+59
+00:05:00,530 --> 00:05:06,530
+القبيح، القطع الحسن هو ما كان بعد وقف تام أو كافٍ،
+
+60
+00:05:06,530 --> 00:05:11,730
+يعني نقطع القراءة قطعًا حسنًا أو يعني جائزا إذا كان 
+
+61
+00:05:11,730 --> 00:05:16,690
+وقفنا على وقف تام أو وقف كافٍ، وعرفنا الوقف التام
+
+62
+00:05:16,690 --> 00:05:20,970
+سابقا، والوقف الكافي عرفناه سابقا وجبنا مثال على 
+
+63
+00:05:20,970 --> 00:05:23,650
+الوقف الكافي وهو ما رضي عن النبي عليه الصلاة
+
+64
+00:05:23,650 --> 00:05:27,130
+والسلام عندما قرأ عبدالله بن مسعود فكيف إذا جئنا 
+
+65
+00:05:27,130 --> 00:05:32,410
+من كل أمة بشهيد وجئنا بك على هؤلاء شهيدة؟ الوقف على 
+
+66
+00:05:32,410 --> 00:05:37,470
+شهيد نسميه وقف كافٍ، وهذا دليل على جواز القطع على 
+
+67
+00:05:37,470 --> 00:05:41,250
+وقف كافٍ، لأن النبي قال له اقطع القراءة أو حسبك،
+
+68
+00:05:41,250 --> 00:05:47,490
+فكان ذلك قطع للقراءة، كذلك يا أخوات القطع القبيح 
+
+69
+00:05:47,490 --> 00:05:53,470
+وهو ما يسمى بالقطع غير جائز، هو ما كان بعد وقف
+
+70
+00:05:53,470 --> 00:05:59,660
+حسن أو وقف قراءته على وقف حسن على رأس الآية، مثال
+
+71
+00:05:59,660 --> 00:06:05,340
+ذلك اللي هو القطع القبيح أو الوقف أو القطع غير 
+
+72
+00:06:05,340 --> 00:06:09,260
+الجائز، مثلا هنا القطع القبيح غير الجائز هو ما كان
+
+73
+00:06:09,260 --> 00:06:14,020
+بعد وقف حسن على رأس الآية، من يأتي بمثال على الوقف
+
+74
+00:06:14,020 --> 00:06:21,260
+الحسن على رأس الآية؟ نفس هذه عندما نقول يا أيها 
+
+75
+00:06:21,260 --> 00:06:27,800
+المزمل، أنا الآن وقفت وقفًا حسنًا، فإذا قطعت القراءة في
+
+76
+00:06:27,800 --> 00:06:31,220
+هذا الأمر فقلت يا أيها المزمل، وانهيت القراءة 
+
+77
+00:06:31,220 --> 00:06:36,040
+وانشغلت عنها بأمر آخر، يسمى هذا القطع غير الجائز أو
+
+78
+00:06:36,040 --> 00:06:40,420
+القطع القبيح، لأنني قطعت القراءة على وقف حسن تم 
+
+79
+00:06:40,420 --> 00:06:44,620
+المانع عنده، لكنه يتعلق بما بعده في اللفظ وفي 
+
+80
+00:06:44,620 --> 00:06:48,610
+المعنى، مثل يا أيها المزمل، صحيح أنه تم المعنى لكن
+
+81
+00:06:48,610 --> 00:06:52,870
+له، لأ هو علاقة مع ما بعده لفظًا ومعنى، فيسمى ذلك
+
+82
+00:06:52,870 --> 00:06:59,830
+القطع القبيح أو القطع غير جائز، ممكن يا أخوات يكون 
+
+83
+00:06:59,830 --> 00:07:04,850
+القطع على وقف كافٍ، إذا كان قد يكون قطع على رؤوس
+
+84
+00:07:04,850 --> 00:07:10,470
+الأجزاء مثلا أو الأحزاب أو الأرباع، مثال ذلك في قول
+
+85
+00:07:10,470 --> 00:07:17,890
+تعالى فانطلق حتى إذا لقي غلاما فقتله، قال أقتلت 
+
+86
+00:07:17,890 --> 00:07:25,410
+نفسًا ذكية بغير نفس لقد جئت شيئا نكره، في قوله نكره
+
+87
+00:07:26,560 --> 00:07:33,440
+هنا يعني بداية جزء، وبالتالي كان وقف كافٍ على بداية
+
+88
+00:07:33,440 --> 00:07:37,280
+جزء أو على رأس آية في بداية جزء يجوز لنا أن نقطع 
+
+89
+00:07:37,280 --> 00:07:42,640
+القراءة على هذه الآية، ومع أنها لم تتم المانع عندها
+
+90
+00:07:42,640 --> 00:07:46,100
+وتتعلق بما بعدها في المانع دون اللفظ، لأن ما بعدها
+
+91
+00:07:46,100 --> 00:07:54,460
+أو يصبح ماءها غورا فلان تستطيع له طلبة، في قوله نقرأ 
+
+92
+00:07:54,460 --> 00:07:58,940
+مع أنها على رأس جزء، لكنها وقف كافٍ، ممكن أن نقطع
+
+93
+00:07:58,940 --> 00:08:05,820
+القراءة ولو كانت هي على رأس جزء، وهذا أمر جائز، إذا 
+
+94
+00:08:05,820 --> 00:08:11,920
+عرفنا يا أخوات أن القطع في قطع حسن، قطع قبيح، القطع
+
+95
+00:08:11,920 --> 00:08:19,440
+الحسن هو ما كان بعد أو على وقف تام 
+
+96
+00:08:19,440 --> 00:08:23,700
+أو كافٍ، وذكرنا مثال على الكافي، والمثال على التام 
+
+97
+00:08:23,700 --> 00:08:29,300
+طبعًا كثير جدا، كذلك القطع القبيح أو القطع غير حسن 
+
+98
+00:08:29,300 --> 00:08:35,900
+هو ما كان بعد وقف حسن على رأس الآية، ويسمى ذلك اللي 
+
+99
+00:08:35,900 --> 00:08:43,660
+هو قطع غير جائز، طبعا من باب أولى القطع على وقف حسن
+
+100
+00:08:43,660 --> 00:08:47,800
+في منتصف الآية بيكون يعني غير جائز، لأنه أصلا الوقف
+
+101
+00:08:47,800 --> 00:08:52,270
+عليه يسمى وقف قبيح، لأن الواحد مثلا هو صحيح إنه حسن
+
+102
+00:08:52,270 --> 00:08:56,190
+لكن يجيز الوقف عليه ولا يجيز الابتداء بما بعده
+
+103
+00:08:56,190 --> 00:09:00,650
+مثلا لو قلنا مثلا الحمد لله من قوله الحمد لله رب 
+
+104
+00:09:00,650 --> 00:09:04,370
+العالمين، الحمد لله الوقف على الحمد لله من قوله
+
+105
+00:09:04,370 --> 00:09:08,610
+الحمد لله رب العالمين، ما اسم الوقف الذي عليه؟ وقف
+
+106
+00:09:08,610 --> 00:09:13,590
+حسن، تم المانع عنده لكنه يتعلق بمبداه لفظًا ومعنى،
+
+107
+00:09:13,590 --> 00:09:17,290
+فيسمى هذا الوقف يعني حسن، لكنه لا يجيز أن نبدأ 
+
+108
+00:09:17,290 --> 00:09:20,970
+بمبداه بل علينا أن نرجع كلمة أو كلمتين حتى يستقيم 
+
+109
+00:09:20,970 --> 00:09:25,350
+المانع ونستأنف التلاوة، فالقطع عليه لو قطعنا وقلنا
+
+110
+00:09:25,350 --> 00:09:29,270
+الحمد لله وأسكرنا الوصفة ومشينا، معناه أن هذا أيضا
+
+111
+00:09:29,270 --> 00:09:35,170
+يعني لا يجيزه لأنه قطع، وإذا كان القطع القبيح على 
+
+112
+00:09:35,170 --> 00:09:39,330
+الوقف الحسن على رأس الآية قبيح، فمن باب أولى القطع 
+
+113
+00:09:39,330 --> 00:09:43,770
+على الوقف الحسن في منتصف الآية يعد ذلك قبيح
+
+114
+00:09:43,770 --> 00:09:49,050
+بيِّن لنا يا أخوات الفرق ما بين القطع والوقف، الوقف
+
+115
+00:09:49,050 --> 00:09:51,910
+معناه أن أنا وقفت على الكلمة القرآنية عشان أتنفس
+
+116
+00:09:52,530 --> 00:09:58,490
+لكن بالنسبة للقطع هو أن أنهي القراءة تمامًا، يعني 
+
+117
+00:09:58,490 --> 00:10:02,670
+بعض الناس لا يفرقون بين الوقف والقطع، فيقول إن 
+
+118
+00:10:02,670 --> 00:10:06,230
+والله قطع، القطع هو نفس الوقف، طبعا خطأ، الوقف إنه 
+
+119
+00:10:06,230 --> 00:10:10,630
+أنا أقول الحمد لله رب العالمين الرحمن الرحيم، وهذا
+
+120
+00:10:10,630 --> 00:10:13,910
+هو السنة يعني السنة أن النبي عليه الصلاة والسلام 
+
+121
+00:10:13,910 --> 00:10:18,590
+كان يقطع قراءته آية آية، ومن هنا صارت عندنا آيات
+
+122
+00:10:18,590 --> 00:10:24,670
+لكن هذا اللي بيسموها اللي هو الوقف يجوز، لكن الذي
+
+123
+00:10:24,670 --> 00:10:31,990
+لا يجوزه هو أن نقطع القراءة وننتهي عن القراءة يعني 
+
+124
+00:10:31,990 --> 00:10:36,450
+نعرض عنها ننشغل بالركوع إن كنا في الصلاة أو ننشغل 
+
+125
+00:10:36,450 --> 00:10:41,390
+بأمر خارجي لا علاقة له بالقراءة ويسمى هذلك قطع، و
+
+126
+00:10:41,390 --> 00:10:45,370
+القطع نفسه فيه قطع جائز وقطع غير جائز، القطع 
+
+127
+00:10:45,370 --> 00:10:51,290
+الجائز هو ما كان على وقف تام أو كافٍ، والقطع غير
+
+128
+00:10:51,290 --> 00:10:56,780
+جائز هو ما كان على وقف حسن، ننتقل الآن يا أخوات إلى
+
+129
+00:10:56,780 --> 00:11:01,340
+يعني موضوع آخر وهو الابتداء، والابتداء لغة يا 
+
+130
+00:11:01,340 --> 00:11:06,520
+أخوات إيه؟ أشروع في الشيء، هذا من حيث اللغة، لغة
+
+131
+00:11:06,520 --> 00:11:11,060
+الابتداء هو أشروع في الشيء، أما في الاصطلاح فمعنى 
+
+132
+00:11:11,060 --> 00:11:15,860
+الابتداء هو أشروع بالقراءة بعد قطع أو وقف، ماذا 
+
+133
+00:11:15,860 --> 00:11:20,160
+يعني هذا؟ إن أنا أريد أن أبدأ أشرع بالقراءة بعد 
+
+134
+00:11:20,160 --> 00:11:28,680
+قطع أو وقف، كيف يكون الشروع في القراءة بعد قطع؟ لأ
+
+135
+00:11:28,680 --> 00:11:34,740
+أنا أقصد يعني من يفسر هذا العنوان، أنا مثلا في
+
+136
+00:11:34,740 --> 00:11:39,520
+الأسبوع الماضي قطعت القراءة على ..وقفت على كلمة 
+
+137
+00:11:39,520 --> 00:11:43,860
+معينة، اليوم بدي أبدأ اسمه ابتداء بعد قطع ولا بعد 
+
+138
+00:11:43,860 --> 00:11:49,240
+وقف؟ ابتداء بعد قطع، لكن أنا جئت بقى أقرأ، لو كنت
+
+139
+00:11:49,240 --> 00:11:54,240
+أنا أقرأ وأخذت نفس ومستمر في القراءة، اسمه ابتداء
+
+140
+00:11:54,240 --> 00:11:58,180
+بعد وقف، يعني لو قلت مثلا الحمد لله رب العالمين، أنا
+
+141
+00:11:58,180 --> 00:12:04,000
+وقفت بدأ أبدأ بعد وقف أقول بسم الله الرحمن الرحيم وقفته
+
+142
+00:12:04,000 --> 00:12:08,560
+وبدأ أبدأ بالبعدها اسمه ابتداء بعد وقفنا مالك يوم
+
+143
+00:12:08,560 --> 00:12:13,080
+الدين إياك نعبد وإياك نستعين عشان أتنفس هذا اسمه 
+
+144
+00:12:13,080 --> 00:12:18,020
+ابتداء بعد وقف أما الابتداء بعد القطع معناته أن
+
+145
+00:12:18,020 --> 00:12:23,320
+أنا قطعت القراءة وانشغلت عنها بأمر خارجي ثم أردت 
+
+146
+00:12:23,320 --> 00:12:26,440
+أن أبدأ بالقراءة ثاني يوم أو بنفس اليوم أو بعد 
+
+147
+00:12:26,440 --> 00:12:31,670
+فترة أبدأ بعد قطع إذا أنا قاعد بتسلسل في القراءة
+
+148
+00:12:31,670 --> 00:12:34,750
+يعني أنهيت الجزء رقم واحد ثاني يوم أريد أن أقرأ
+
+149
+00:12:34,750 --> 00:12:39,510
+الجزء الذي يليه من أول رقم اثنين اسمه ابتدأت بعد
+
+150
+00:12:39,510 --> 00:12:45,010
+قطع فهذا هو معناته عنوان الشروع في القراءة بعد قطع
+
+151
+00:12:45,010 --> 00:12:50,330
+أو وقف فإذا كان الابتداء بعد قطع فيستحب الاستعاذة 
+
+152
+00:12:50,330 --> 00:12:55,820
+والبسملة إذا كان أنا بدأ أبدأ بعد قطع يستحب 
+
+153
+00:12:55,820 --> 00:12:59,400
+الاستعاذة والبسملة، ماذا يعني هذا المعنى أو هذه
+
+154
+00:12:59,400 --> 00:13:04,680
+الجملة؟ يعني إذا أردت أن أبدأ القراءة بعد قطع،
+
+155
+00:13:04,680 --> 00:13:09,700
+قطعت القراءة في الماضية واليوم بدأ أبدأ يعني من 
+
+156
+00:13:09,700 --> 00:13:15,100
+أول وجديد، يستحب الاستعاذة والبسملة، إذا كان
+
+157
+00:13:15,100 --> 00:13:19,400
+يعني من أثناء الصورة، يعني أقول مثلا أعوذ بالله من 
+
+158
+00:13:19,400 --> 00:13:24,920
+الشيطان الرجيم بسم الله الرحمن الرحيم لله ما في
+
+159
+00:13:24,920 --> 00:13:29,880
+السماوات وما في الأرض إذا أنا بدأت القراءة بعد
+
+160
+00:13:29,880 --> 00:13:35,860
+قطع يستحب ليه الآن أن أستعيد وأن أبسم وتتعين 
+
+161
+00:13:35,860 --> 00:13:38,760
+البسملة إن كانت ابتدائها من أول الصورة يعني إلا
+
+162
+00:13:38,760 --> 00:13:42,010
+إذا كنت أنا بدأ أبدأ من أول الصورة يعني أنا خلصت
+
+163
+00:13:42,010 --> 00:13:46,710
+صورة البقرة وأريد أن أبدأ اليوم من صورة آل عمران
+
+164
+00:13:46,710 --> 00:13:52,070
+يستحب الاستعاذة وتتعين البسملة لماذا تتعين
+
+165
+00:13:52,070 --> 00:13:57,280
+البسملة؟ يعني ما معنى تتعين البسملة؟ يعني يجب علي 
+
+166
+00:13:57,280 --> 00:14:00,900
+أن أقول بسم الله الرحمن الرحيم لأن أوائل الصور
+
+167
+00:14:00,900 --> 00:14:05,660
+لابد أن نذكر اسم الله سبحانه وتعالى لأن النبي عليه
+
+168
+00:14:05,660 --> 00:14:10,120
+الصلاة والسلام يقول كل أمر ذي بال لا يبدأ باسم 
+
+169
+00:14:10,120 --> 00:14:14,660
+الله فهو أبتر فأنا بدأ أبدأ أقول بسم الله الرحمن 
+
+170
+00:14:14,660 --> 00:14:18,560
+الرحيم لأنه بدأت من أول الصورة لكن لو كنت القراءة 
+
+171
+00:14:18,560 --> 00:14:22,560
+من أثناء الصورة، يعني بدأت القراءة بعد قطع من
+
+172
+00:14:22,560 --> 00:14:26,840
+أثناء الصورة، فيستحب الاستعاذة والبسملة، إلا إذا
+
+173
+00:14:26,840 --> 00:14:30,940
+كان أنا بدأ أبدأ من أول الصورة، فتتعين عند ذلك
+
+174
+00:14:30,940 --> 00:14:35,400
+البسملة إلا في صورة واحدة من القرآن، وهي صورة أي؟ 
+
+175
+00:14:35,400 --> 00:14:38,860
+التوبة. لماذا صورة التوبة لا تبدأ باسم الله الرحمن
+
+176
+00:14:38,860 --> 00:14:39,380
+الرحيم؟
+
+177
+00:14:41,920 --> 00:14:46,400
+بسم الله الرحمن الرحيم فيها رحمة والتوبة فيها 
+
+178
+00:14:46,400 --> 00:14:53,100
+كتابة صحيح لأن صورة التوبة من أول آياتها إعلان
+
+179
+00:14:53,100 --> 00:14:56,580
+الحرب على المشركين وعلى المنافقين وعلى الكفار
+
+180
+00:14:56,580 --> 00:15:00,800
+واليهود فيعني براءة من الله ورسوله إلى الذين
+
+181
+00:15:00,800 --> 00:15:04,130
+عاهدتم من المشركين فسيحوا في الأرض أربعة أشهر
+
+182
+00:15:04,130 --> 00:15:07,930
+واعلموا أنكم غيروا معجز الله وأن الله مخز الكافرين
+
+183
+00:15:07,930 --> 00:15:11,650
+إذا من أول آياتها إعلان الحرب على الكفار وعلى
+
+184
+00:15:11,650 --> 00:15:15,330
+المشركين ولذلك الآية ناسفة بعد بسم الله الرحمن
+
+185
+00:15:15,330 --> 00:15:19,350
+الرحيم أن نبدأ بعدها مباشرة اللي هو إعلان الحرب
+
+186
+00:15:19,350 --> 00:15:25,450
+على الكافرين لذلك الشروع معناه الابتداء بعد قطع 
+
+187
+00:15:25,450 --> 00:15:28,920
+الشروع في القراءة بعد قطع أو وقف الشروع في القراءة
+
+188
+00:15:28,920 --> 00:15:32,440
+بعد قطع تستحب الاستعاذة والبسملة إذا كان أثناء
+
+189
+00:15:32,440 --> 00:15:36,080
+الصورة أما إذا كان أول الصورة فنحن تستحب
+
+190
+00:15:36,080 --> 00:15:39,760
+الاستعاذة وتتعين البسملة إذا أردنا أن نبدأ من أول
+
+191
+00:15:39,760 --> 00:15:43,860
+الصورة إلا إذا أردنا أن نبدأ من صورة التوبة
+
+192
+00:15:43,860 --> 00:15:47,480
+ففيها إعلان الحرب على الكفار لا تتناسب باسم الله
+
+193
+00:15:47,480 --> 00:15:50,920
+الرحمن الرحيم مع براءة من الله ورسوله اللي هي
+
+194
+00:15:50,920 --> 00:15:54,970
+إعلان الحرب على الكفار هذا اللي هو إذا كان بعد قطع
+
+195
+00:15:54,970 --> 00:15:59,430
+وإن كان الابتداء يا أخوات بعد وقف فلا يؤتى لا 
+
+196
+00:15:59,430 --> 00:16:04,450
+بالاستعادة ولا بالبسملة إلا إذا كان من أول صورة 
+
+197
+00:16:04,450 --> 00:16:08,490
+يستحب أو يعني علينا نقول بسم الله الرحمن الرحيم
+
+198
+00:16:08,490 --> 00:16:12,830
+يعني تتعين البسملة إلا من صورة التوبة فلا نقول بسم
+
+199
+00:16:12,830 --> 00:16:16,030
+الله الرحمن الرحيم ما معنى إذا كان الابتداء بعد
+
+200
+00:16:16,030 --> 00:16:18,970
+وقف فلا يؤتى لا بالاستعادة ولا بالبسملة
+
+201
+00:16:24,710 --> 00:16:27,610
+فبنقول ابتداء بعد وقف، فما بيقولش عوض القرآن يشتغل
+
+202
+00:16:27,610 --> 00:16:30,010
+باسم الله، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+203
+00:16:30,010 --> 00:16:31,650
+بالرحمن، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+204
+00:16:31,650 --> 00:16:31,870
+بالرحمن، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+205
+00:16:31,870 --> 00:16:32,590
+بالرحمن، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+206
+00:16:32,590 --> 00:16:38,250
+بالرحمن، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+207
+00:16:38,250 --> 00:16:49,970
+بالرحمن، يشتغل بالرحمن، يشتغل بالرحمن، يشتغل
+
+208
+00:16:49,970 --> 00:16:58,020
+بالرحمن، يشتغل بالرحمن الرحيم مالك يوم الدين
+
+209
+00:16:58,020 --> 00:17:03,480
+أنا الآن أوقفت القراءة وابتدأت القراءة بعد وقف
+
+210
+00:17:03,480 --> 00:17:07,100
+يعني الحمد لله رب العالمين وقفته الرحمن الرحيم
+
+211
+00:17:07,100 --> 00:17:12,460
+بدأته ووقفته الرحمن الرحيم مالك يوم الدين وهكذا
+
+212
+00:17:12,460 --> 00:17:18,280
+اسمه ابتداء بعد وقف يعني علينا لا يؤتى لا
+
+213
+00:17:18,280 --> 00:17:21,060
+بالاستعادة ولا بالبسملة يعني مش محتاج مثلا أن نقول
+
+214
+00:17:21,060 --> 00:17:23,820
+الحمد لله رب العالمين بعدين أقول أعوذ بالله من
+
+215
+00:17:23,820 --> 00:17:26,120
+الشيطان الرجيم بسم الله الرحمن الرحيم الرحمن
+
+216
+00:17:26,120 --> 00:17:28,020
+الرحيم أعوذ بالله من الشيطان الرجيم بسم الله
+
+217
+00:17:28,020 --> 00:17:31,710
+الرحمن الرحيم مالك يوم الدين فهذا لا يؤتى به إلا
+
+218
+00:17:31,710 --> 00:17:36,250
+إذا كان أنهيت الصورة وأردت أن أبدأ في صورة جديدة
+
+219
+00:17:36,250 --> 00:17:42,470
+فتتعين عند ذلك البسملة طيب عندنا كذلك أمثلة على
+
+220
+00:17:42,470 --> 00:17:50,760
+جواز القطع على الوقف الكافي إذا كان من أوائل أقصر
+
+221
+00:17:50,760 --> 00:17:53,900
+من الابتداء يا أخوات .. أيش ينقصر من الابتداء؟
+
+222
+00:17:53,900 --> 00:17:59,360
+الابتداء طبعا زي ما قلنا أن الوقف .. القطع ينقسم
+
+223
+00:17:59,360 --> 00:18:06,420
+إلى حسن وقبيح، كذلك الابتداء ينقسم إلى حسن وقبيح،
+
+224
+00:18:06,420 --> 00:18:11,000
+الابتداء الحسن طبعا فيه أن ابتداء بعد قطع وابتداء
+
+225
+00:18:11,000 --> 00:18:16,600
+بعد وقف، الابتداء بعد قطع ينقسم إلى قسمين جائز وغير
+
+226
+00:18:16,600 --> 00:18:20,340
+جائز، يعني حسن وقبيح، الابتداء الجائز يا
+
+227
+00:18:20,340 --> 00:18:23,660
+أخوات هو ما كان بعد قطع جائز، يعني في شيء ابتداء
+
+228
+00:18:23,660 --> 00:18:29,770
+جائز وفي ابتداء غير جائز وفي عندنا قطع جائز وفي قطع
+
+229
+00:18:29,770 --> 00:18:34,170
+غير جائز الابتداء الجائز هو ما كان بعد قطع جائز
+
+230
+00:18:34,170 --> 00:18:41,470
+والابتداء غير الجائز يعني القبيح هو ما كان بعد قطع
+
+231
+00:18:41,470 --> 00:18:45,740
+غير جائز نشوف هنا مثلا الآن نريد أن نبدأ ابتداء
+
+232
+00:18:45,740 --> 00:18:51,680
+جائز بعد قطع جائز والقطع الجائز يكون على وقف تم أو
+
+233
+00:18:51,680 --> 00:18:55,760
+كافي نشوف الأمثلة مثلا هنا في عندنا مثال من سورة
+
+234
+00:18:55,760 --> 00:19:00,000
+هود بقوله طبعا نبدأ إذا أردنا أن نبدأ وإلى عاد
+
+235
+00:19:00,000 --> 00:19:05,160
+أخاهم هود قال يا قوم اعبدوا الله ما لكم من إله 
+
+236
+00:19:05,160 --> 00:19:11,740
+غيره إن أنتم إلا مفترون بدأنا من قوله وإلى عاد
+
+237
+00:19:11,740 --> 00:19:17,000
+يعني قصة جديدة بعد أن انتهت قصة من قصة سيدنا نوح
+
+238
+00:19:17,000 --> 00:19:21,200
+التي يقول الله سبحانه وتعالى فيها تلك من أنباء
+
+239
+00:19:21,200 --> 00:19:26,980
+الغيب نوحيها إليك ما كنت تعلمها أنت ولا قومك من 
+
+240
+00:19:26,980 --> 00:19:33,110
+قبل هذا فاصبر إن العاقبة للمتقين خلصنا سورة هود آية 
+
+241
+00:19:33,110 --> 00:19:38,370
+رقم 49 وبدأنا بسورة هود آية رقم 50 وإلى عاد
+
+242
+00:19:38,370 --> 00:19:44,430
+أخاهم هود كلام جديد إذا اسم هذا ابتداء جائز أو
+
+243
+00:19:44,430 --> 00:19:51,770
+ابتداء حسن بعد قطع حسن أو بعد قطع جائز على وقف
+
+244
+00:19:51,770 --> 00:19:56,290
+تام طبعا الوقف التام تم المنع عنده لا يتعلق بالبعد
+
+245
+00:19:56,290 --> 00:20:00,330
+ولا لفظ ولا معنى وبدأنا بقصة جديدة وهي قصة سيدنا
+
+246
+00:20:00,330 --> 00:20:04,070
+هود عليه الصلاة والسلام مع قومه اللي هي عاد بقوله
+
+247
+00:20:04,070 --> 00:20:09,900
+وإلى عاد أخاهم هود النوع الثاني يا أخوات من أنواع 
+
+248
+00:20:09,900 --> 00:20:15,040
+القطع وهو القطع القبيح أو القطع غير جائز القطع
+
+249
+00:20:15,040 --> 00:20:19,580
+القبيح أو القطع غير جائز هو ما كان أي بعد قطع
+
+250
+00:20:19,580 --> 00:20:24,520
+الابتداء غير الجائز بعد قطع غير جائز أو بعد قطع 
+
+251
+00:20:24,520 --> 00:20:29,500
+يسمى قبيح والقطع القبيح قلنا بيكون على وقف حسن 
+
+252
+00:20:29,500 --> 00:20:34,370
+مثل موقفنا احنا على قوله يا أيها المزمل لو قطعنا
+
+253
+00:20:34,370 --> 00:20:38,290
+القراءة يا أيها المزمل اسم هذا قطع قبيح لأننا
+
+254
+00:20:38,290 --> 00:20:43,530
+قطعنا القراءة على وقف حسن على رأس الآية هنا مثلا
+
+255
+00:20:43,530 --> 00:20:47,030
+مثال آخر لو بدأنا مثلا الابتداء من سورة البقرة 
+
+256
+00:20:47,030 --> 00:20:51,790
+بقوله في الدنيا والآخرة ويسألونك عن اليتامة طبعا
+
+257
+00:20:51,790 --> 00:20:55,750
+في الدنيا والآخرة ابتدأنا بها ابتداء غير صحيح ليش؟
+
+258
+00:20:55,750 --> 00:20:59,610
+لأن كلمة في الدنيا والآخرة متعلقة باللي بعدها يعني 
+
+259
+00:20:59,610 --> 00:21:03,890
+لفظا ومعنى وبالتالي مثلا هي في قول تعالى ويسألونك
+
+260
+00:21:03,890 --> 00:21:08,670
+ماذا ينفقون قل العفو كذلك يبين الله لكم الآيات 
+
+261
+00:21:08,670 --> 00:21:13,100
+لعلكم تتفكرون في الدنيا والآخرة في الدنيا والآخرة
+
+262
+00:21:13,100 --> 00:21:18,520
+متعلقة بقوله لعلكم تتفكرون لذلك لو قطعنا القراءة
+
+263
+00:21:18,520 --> 00:21:23,680
+على تتفكرون وأردنا أن نبدأ بقوله في الدنيا والآخرة
+
+264
+00:21:23,680 --> 00:21:28,400
+يسمى هذا الابتداء أيش ابتداء قبيح لأنه بعد قطع 
+
+265
+00:21:28,400 --> 00:21:33,720
+قبيح على وقف حسن على رأس آية نعم
+
+266
+00:21:45,000 --> 00:21:49,440
+هي الآية المبينة هنا لعلكم تتفكرون تم المعنى عندها
+
+267
+00:21:49,440 --> 00:21:54,280
+لكنها تتعلق بما بعدها لفظا ومعنى يعني عشان على رأس
+
+268
+00:21:54,280 --> 00:21:58,100
+الآية الوقف على رأس الآية أيش اسمه؟ وقف حسن يجوز
+
+269
+00:21:58,100 --> 00:22:03,890
+الوقف عليه ويجوز الابتداء وما بعدها هو جائز لكن
+
+270
+00:22:03,890 --> 00:22:10,250
+القطع قبيح لأننا قطعنا القراءة على وقف حسن على رأس
+
+271
+00:22:10,250 --> 00:22:14,370
+الآية الأولى والأفضل إذا أردنا أن نبدأ القراءة أن 
+
+272
+00:22:14,370 --> 00:22:18,230
+نرجع نقرأ ويسألونك ماذا ينفقون قل العفو كذلك
+
+273
+00:22:18,230 --> 00:22:21,950
+ويبين الله لكم الآيات لعلكم تتفكرون في الدنيا و
+
+274
+00:22:21,950 --> 00:22:26,590
+الآخرة ويسألونك عن اليتامة حتى يكون المعنى لأن
+
+275
+00:22:26,590 --> 00:22:30,590
+الوقفات كلها سواء وقف تم ولا وقف كثي ولا وقف حسن
+
+276
+00:22:30,590 --> 00:22:34,450
+ولا أنواع الوقف المتعددة الغرض منها أننا نقف إذا 
+
+277
+00:22:34,450 --> 00:22:39,590
+تم المعنى والابتداء أيضا نبتدأ القراءة حتى بعد أن 
+
+278
+00:22:39,590 --> 00:22:43,870
+يكون المعنى قد اكتمل هذا يا أخوات هو القطع
+
+279
+00:22:44,460 --> 00:22:48,580
+والابتداء وخدنا الابتداء الحسن والابتداء الحسن بعد
+
+280
+00:22:48,580 --> 00:22:53,940
+قطع قد يكون ابتداء حسن بعد قطع حسن والابتداء 
+
+281
+00:22:53,940 --> 00:22:59,720
+القبيح بعد قطع قبيح عندنا كذلك الابتداء بعد وقف
+
+282
+00:22:59,720 --> 00:23:04,340
+الابتداء بعد وقف أيضا ينقسم إلى قسمين في الابتداء
+
+283
+00:23:04,340 --> 00:23:10,510
+جائز وابتداء الابتداء الجائز ما هو؟ هو الابتداء
+
+284
+00:23:10,510 --> 00:23:14,550
+بكلام يفيده معنى، يعني أبدأ الكلام الذي أريد أن 
+
+285
+00:23:14,550 --> 00:23:21,540
+أبدأه ابتداء بمعنى حسن، أفاد معنى، لكن لو أنا ابتدأت
+
+286
+00:23:21,540 --> 00:23:26,880
+القراءة بكلام لا يؤدي معنى لأنه لشدّ بتعلقه بما 
+
+287
+00:23:26,880 --> 00:23:33,200
+بعده فيسمى ذلك الابتداء غير جائز، نشوف هنا يعني
+
+288
+00:23:33,200 --> 00:23:37,180
+عندنا الابتداء الـ .. دائما الابتداء بيكون بعد وقف
+
+289
+00:23:37,180 --> 00:23:42,800
+تام أو وقف حسن أو وقف يعني كافي على أساس يكون
+
+290
+00:23:42,800 --> 00:23:47,670
+الكلام كله كلام حسن على رأس الآية وكل مفيد، الابتداء
+
+291
+00:23:47,670 --> 00:23:51,170
+الثاني يا أخوات بعد وقف اللي يسمى الابتداء غير
+
+292
+00:23:51,170 --> 00:23:54,510
+جائز بعد وقف، طبعا ابنُ عرف أنه في عندنا ابتداء بعد
+
+293
+00:23:54,510 --> 00:23:59,430
+قطع وابتداء بعد وقف، الابتداء بعد قطع إما أن يكون
+
+294
+00:23:59,430 --> 00:24:07,690
+ابتداء حسن أو ابتداء قبيح، الابتداء الحسن
+
+295
+00:24:07,690 --> 00:24:11,850
+بعد قطع حسن، والابتداء القبيح بعد قطع قبيح، الآن
+
+296
+00:24:11,850 --> 00:24:16,810
+القسم الثاني هو الابتداء بعد وقف، الابتداء بعد وقف
+
+297
+00:24:16,810 --> 00:24:22,110
+طبعا أيضا بينقسم إلى قسمين، ابتداء حسن وابتداء غير
+
+298
+00:24:22,110 --> 00:24:26,850
+حسن، الابتداء الحسن هو ما أدى معنى حسن متواصل و
+
+299
+00:24:26,850 --> 00:24:30,770
+اكتمل معنى عنده، والابتداء الحسن بعد .. ده خليني 
+
+300
+00:24:30,770 --> 00:24:36,250
+أقوله ابتداء تام بعد وقف تام أو كافي أو حتى حسن على
+
+301
+00:24:36,250 --> 00:24:41,710
+رأس الآية، لكن الابتداء بعد وقف القبيح يعني انتظار
+
+302
+00:24:41,710 --> 00:24:47,390
+قبيح بعد وقت، هو ما كان بدأ بكلام لا يفيده معنى
+
+303
+00:24:47,390 --> 00:24:53,390
+مثال ذلك مثلا في قوله مثلا نبدأ لقد كفر الذين
+
+304
+00:24:53,390 --> 00:24:57,350
+قالوا إن الله ثالث ثلاثة، وما من إله إلا إله واحد
+
+305
+00:24:57,350 --> 00:25:03,630
+لو واحد مثلا أو واحد قرأ فقال لقد كفر الذين قالوا
+
+306
+00:25:03,630 --> 00:25:10,360
+ووقف، وبعدين بدأ بقوله إن الله ثالث ثلاثة، في قوله
+
+307
+00:25:10,360 --> 00:25:15,560
+إن الله ثالث ثلاثة ماذا يعني؟ يعني بأكد أن الله
+
+308
+00:25:15,560 --> 00:25:19,840
+ثالث ثلاثة، لكن المعنى الصحيح أن الله سبحانه وتعالى
+
+309
+00:25:19,840 --> 00:25:24,600
+يبين لنا أن الذين قالوا إن الله ثالث ثلاثة لقد
+
+310
+00:25:24,600 --> 00:25:30,760
+كفروا، فقال تعالى لقد كفر الذين قالوا إن الله ثالث 
+
+311
+00:25:30,760 --> 00:25:35,280
+ثلاثة، فبيكون لو واحد بدأ من إن الله ثالث ثلاثة 
+
+312
+00:25:35,280 --> 00:25:40,820
+معناته قراءته غير صحيحة، كذلك لو بدأ القارئ بقوله
+
+313
+00:25:40,820 --> 00:25:46,200
+لأعبد الذي فضرني، معناه هذا الكلام أنه يعني ينفي
+
+314
+00:25:46,200 --> 00:25:53,020
+أنه يعبد الذي فضره من قوله تعالى: وما لي لأعبد الذي 
+
+315
+00:25:53,020 --> 00:25:58,180
+فطرني وإليه ترجعون، وما لي لأعبد الذي فطرني، لو قال
+
+316
+00:25:58,180 --> 00:26:02,260
+وما لي، وبدأ الكلام لأعبد الذي فطرني، فالابتداء اللي
+
+317
+00:26:02,260 --> 00:26:07,640
+هنا يسمى ابتداء غير جائز أو ابتداء قبيح، ولو أنه 
+
+318
+00:26:07,640 --> 00:26:12,600
+كان على وقف لأنه أدى معنى غير المعنى المراد، كذلك 
+
+319
+00:26:12,600 --> 00:26:16,720
+مثال آخر على الابتداء غير الجائز لو بدأ من قوله
+
+320
+00:26:16,720 --> 00:26:23,050
+أبي لهب وتب، ما معنى أبي لهب وتب؟ يعني لم تفيد معنى
+
+321
+00:26:23,050 --> 00:26:29,030
+لكن لابد أن يبدأ الكلام من أوله فيقول تبت يدى أبي
+
+322
+00:26:29,030 --> 00:26:34,490
+لهب وتب، بهذا الكلام بكون بدأ القراءة ابتداءا
+
+323
+00:26:34,490 --> 00:26:38,570
+صحيحا، لكن لو قال أبي لهب وتب معناته أنه بدأ
+
+324
+00:26:38,570 --> 00:26:42,750
+الكلام بكلام لا يفيد معناه، لأنه الابتداء القبيح هو
+
+325
+00:26:42,750 --> 00:26:47,900
+الابتداء بكلام لا يفيده معناه، خلصنا الآن يا أخوات
+
+326
+00:26:47,900 --> 00:26:52,120
+الابتداء، نكتفي بهذا القدر ونكمل إن شاء الله في
+
+327
+00:26:52,120 --> 00:26:54,280
+اللقاء القادم، مبارك الله فيكم والسلام عليكم
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LlEQaN_Tqns.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LlEQaN_Tqns.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0bc8a1a622a876a6dcefe577d36e144439763d94
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/LlEQaN_Tqns.srt
@@ -0,0 +1,1771 @@
+1
+00:00:00,000 --> 00:00:02,680
+موسيقى
+
+2
+00:00:11,710 --> 00:00:14,130
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن 
+
+3
+00:00:14,130 --> 00:00:18,710
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى 
+
+4
+00:00:18,710 --> 00:00:23,670
+آله وصحبه وسلم  استكمالًا للموضوع السابق أخذنا 
+
+5
+00:00:23,670 --> 00:00:27,070
+أحكام النون الساكنة والتنوين وبينا أن النون 
+
+6
+00:00:27,070 --> 00:00:31,810
+الساكنة والتنوين لها أربع أحكام هي الإضغام 
+
+7
+00:00:31,810 --> 00:00:38,860
+والإظهار والإخفاء والإقلاب  و الإخفاء أخذنا جزء من 
+
+8
+00:00:38,860 --> 00:00:42,900
+الموضوع الأول وهو الإضغام ومعناه إدخال الحرف الأول 
+
+9
+00:00:42,900 --> 00:00:47,340
+في الحرف الثاني بحيث يصبحان حرفًا واحدًا مشددًا من 
+
+10
+00:00:47,340 --> 00:00:52,460
+جنس الثاني وحروف الإضغام مجموعة في قوله يرملون ستة 
+
+11
+00:00:52,460 --> 00:00:57,370
+أحرف وينقسم الإضغام إلى قسمين إضغام بغنة وإضغام 
+
+12
+00:00:57,370 --> 00:01:03,430
+بغير غنة الإضغام بغنة حروفه ينمو أي حرف من النون 
+
+13
+00:01:03,430 --> 00:01:06,750
+الساكنة أو التنوين جاء بعدها أي حرف من حروف 
+
+14
+00:01:06,750 --> 00:01:13,070
+الإضغام ينمو في عندنا إضغام بيكون زي ما يعمل من 
+
+15
+00:01:13,070 --> 00:01:19,840
+نعمة ميواق أو إضغام بغير غنة اللي هي اللام والراء 
+
+16
+00:01:19,840 --> 00:01:25,840
+نقول من ربهم ومن لدنا طبعًا هذه إضغام بغير غنة و
+
+17
+00:01:25,840 --> 00:01:30,400
+يشترط في الإضغام شرط مهم من من الأخوات يعرف ما هو 
+
+18
+00:01:30,400 --> 00:01:36,700
+الشرط المهم الذي يجب أن يتوفر في الإضغام يجب أن 
+
+19
+00:01:36,700 --> 00:01:40,080
+يكون الإضغام موجودًا في كلمتين لا يكون الإضغام في 
+
+20
+00:01:40,080 --> 00:01:49,260
+كلمة واحدة نقول من ربهم، من لدنا، من وق، من نعمة،
+
+21
+00:01:49,260 --> 00:01:52,900
+لكن ما بنفع تكون في كلمة واحدة، فإذا حصل وجاء حرف 
+
+22
+00:01:52,900 --> 00:01:57,980
+النون الساكنة وبعدها حرف من حروف الإضغام في كلمة 
+
+23
+00:01:57,980 --> 00:02:03,780
+واحدة، نطلق عليه اسم، ما هو اسمه؟ الإظهار المطلق،
+
+24
+00:02:03,780 --> 00:02:08,120
+وهذا يا أخوات لا يتوفر إلا في كم كلمة؟ أربع 
+
+25
+00:02:08,120 --> 00:02:13,960
+كلمات، من يذكر هذه الكلمات الأربع؟ فضلي، القنوان لا 
+
+26
+00:02:13,960 --> 00:02:18,440
+نطبق القاعدة على هذه الكلمات الأربع لا نقول عن 
+
+27
+00:02:18,440 --> 00:02:25,320
+كلمة دنيا نقول دُوَيّة ولا عن كلمة بنيان نقول بيان 
+
+28
+00:02:25,320 --> 00:02:31,620
+ولا عن كلمة صنوان نقول صوان ولا عن كلمة .. يعني ..
+
+29
+00:02:32,160 --> 00:02:36,580
+قنوان نقول قوان طبعًا هي أربع كلمات نقول دنيا، 
+
+30
+00:02:36,580 --> 00:02:41,620
+صنوان، قنوان، بنيان ولأن حرف النون الساكنة جاء 
+
+31
+00:02:41,620 --> 00:02:45,940
+بعدها حرف من الحروف الإضغام في نفس الكلمة نسميه له 
+
+32
+00:02:45,940 --> 00:02:51,740
+اسم خاص ما اسمه يا بنات؟ الإظهار المطلق وفي عندنا 
+
+33
+00:02:51,740 --> 00:02:55,900
+إظهار مطلق في كلمة مثل هذه الكلمات الأربع وفي 
+
+34
+00:02:55,900 --> 00:03:01,240
+عندنا شبيه بالإظهار المطلق وهو يقع في جملة وهو 
+
+35
+00:03:01,240 --> 00:03:06,360
+موجود في كلمة ياسين والقرآن الحكيم لنضغم فنقول 
+
+36
+00:03:06,360 --> 00:03:11,500
+ياسين والقرآن الحكيم ولا حتى نون والقلم وما يسطرون 
+
+37
+00:03:11,500 --> 00:03:16,100
+لنقول نو والقلم وما يسطرون لأن هذه في .. نسميها 
+
+38
+00:03:16,100 --> 00:03:22,210
+إظهار مطلق في جملة أنهينا عند هذه النقطة وننتقل إلى 
+
+39
+00:03:22,210 --> 00:03:28,210
+الإضغام الكامل أو الناقص يعني له نوع آخر أو نوع من 
+
+40
+00:03:28,210 --> 00:03:32,170
+أنواع الإضغام وهو الإضغام من حيث الكمال أو النقص 
+
+41
+00:03:32,170 --> 00:03:37,450
+في أخوات إضغام كامل وفي إضغام ناقص وفي إضغام كامل 
+
+42
+00:03:37,450 --> 00:03:42,290
+بالإجماع يعني نفس الحروف، حروف يرملون، الياء والراء 
+
+43
+00:03:42,290 --> 00:03:47,490
+والميم واللام والواو والنون، ينقسم إلى ثلاث أقسام، 
+
+44
+00:03:47,490 --> 00:03:52,710
+في إضغام كامل بإجماع العلماء، في إضغام ناقص بإجماع 
+
+45
+00:03:52,710 --> 00:03:58,630
+العلماء، في إضغام كامل بالأقوى 
+
+46
+00:03:58,630 --> 00:04:03,420
+أو بالأرجح أو على الراجح أما الإضغام الكامل بالإجماع 
+
+47
+00:04:03,420 --> 00:04:09,040
+فهو لا يكون إلا من حرفين من حروف يرملون ما هما هذان 
+
+48
+00:04:09,040 --> 00:04:13,700
+الحرفان؟ اللام والراء فضلي، اللام والراء إذا النوع 
+
+49
+00:04:13,700 --> 00:04:19,440
+الأول من أنواع الإضغام من حيث الكمال أو النقص هو 
+
+50
+00:04:19,440 --> 00:04:25,580
+الإضغام الكامل مع اللام والراء اللام والراء يعني نون 
+
+51
+00:04:25,580 --> 00:04:32,140
+ساكنة أو راء أو تنوين جاء بعدها حرف اللام أو الراء 
+
+52
+00:04:32,140 --> 00:04:36,900
+يُضغم إضغامًا كاملًا إذا هنا الإضغام الكامل ويكون 
+
+53
+00:04:36,900 --> 00:04:42,000
+عند حرفي اللام والراء باتفاق العلماء وهو إدخال حرف 
+
+54
+00:04:42,000 --> 00:04:47,580
+ساكن في حرف متحرك بحيث يصبحان حرفًا واحدًا مشددًا من 
+
+55
+00:04:47,580 --> 00:04:53,320
+جنس الثاني مع إدخال ذات الحرف وصفته يعني ماذا 
+
+56
+00:04:53,320 --> 00:04:59,060
+سمينا الإضغام الكامل كاملًا؟ لأن النون الساكنة أو 
+
+57
+00:04:59,060 --> 00:05:03,420
+التنوين تُضغم إضغامًا كاملًا في الحرف اللام أو الراء 
+
+58
+00:05:03,420 --> 00:05:08,760
+بحيث يعني يدخل ذات الحرف وكذلك صفة الحرف لأن في 
+
+59
+00:05:08,760 --> 00:05:13,000
+عندنا ذات الحرف اللي هي الـ N وصفات الحرف اللي أهم 
+
+60
+00:05:13,000 --> 00:05:18,320
+صفات النون اللي هي الغنة لذلك نجد أن ذات الحرف و
+
+61
+00:05:18,320 --> 00:05:23,540
+صفات الحرف تدخل مباشرة في الحرف الذي يليه فنقول 
+
+62
+00:05:23,540 --> 00:05:29,590
+مثلًا من ربهم، نقول كذلك من لدنا إنما لا نضغم لا 
+
+63
+00:05:29,590 --> 00:05:37,330
+نقول من ربهم ولا نقول من لدنا لأنه ما فيها غنة نقول 
+
+64
+00:05:37,330 --> 00:05:42,970
+مباشرة من ربهم ومن لدنا نجد أن النون الساكنة دخلت 
+
+65
+00:05:42,970 --> 00:05:47,670
+صفاتها وذاتها في الحرف الذي يليها الذي هو اللام 
+
+66
+00:05:47,670 --> 00:05:52,070
+والراء هذا هو النوع الأول وهو الإضغام الكامل ولا 
+
+67
+00:05:52,070 --> 00:05:56,760
+يكون إلا مع حرف اللام أو الراء النوع الثاني يا أخوات 
+
+68
+00:05:56,760 --> 00:06:01,740
+من حيث الكمال أو النقص هو الإضغام الناقص ويكون 
+
+69
+00:06:01,740 --> 00:06:06,460
+فيه حرفين مع الياء أو الواو باتفاق العلماء أو 
+
+70
+00:06:06,460 --> 00:06:11,410
+بإجماع العلماء الذي هو نفسه يدخل حرف ساكن في حرف 
+
+71
+00:06:11,410 --> 00:06:16,670
+متحرك بحيث يصبحان حرفًا واحدًا مشددًا من جنس الثاني 
+
+72
+00:06:16,670 --> 00:06:22,570
+ولكن يدخل ذات الحرف ويبقى خلفه صفاته يعني لا يكون 
+
+73
+00:06:22,570 --> 00:06:26,870
+كاملًا بل يكون ناقص لماذا سميناه ناقصًا؟ لأن ذات 
+
+74
+00:06:26,870 --> 00:06:31,210
+الحرف يعني ذات حرف النون هو الذي يُضغم في الواو 
+
+75
+00:06:31,210 --> 00:06:36,960
+والياء ويبقى خلفه صفاته عشان هيك نص النون هي التي 
+
+76
+00:06:36,960 --> 00:06:42,360
+تُضغم وتبقى الصفة النصف الثاني وهو الصفات فنقول 
+
+77
+00:06:42,360 --> 00:06:53,000
+مثلًا ميعمل هذه غنة من ورائهم من واقع الواو والياء 
+
+78
+00:06:53,000 --> 00:06:58,320
+تُضغم النون معها إضغامًا ناقصًا بمعنى أن نص النون و
+
+79
+00:06:58,320 --> 00:07:02,160
+هو ذات النون تدخل في حرف الواو أو الياء وتبقى 
+
+80
+00:07:02,160 --> 00:07:08,040
+خلفها صفاتها فتظهر صفة الغنة لذلك بنسمي إضغام بغنة 
+
+81
+00:07:08,040 --> 00:07:13,880
+أو بنسمي إضغام ناقص لأن نص الإضغام النوع الثالث يا 
+
+82
+00:07:13,880 --> 00:07:19,180
+أخوات هو إضغام كامل على الراجح وهذا يكون مع حرفين 
+
+83
+00:07:19,180 --> 00:07:24,520
+الميم وكذلك النون لماذا يسمى إضغام كامل؟ لأن 
+
+84
+00:07:24,520 --> 00:07:28,180
+بعض العلماء قالوا كامل وبعض العلماء قالوا ناقص 
+
+85
+00:07:28,180 --> 00:07:32,440
+إضغام كامل وبعضهم قالوا إضغام ناقص لماذا سميناها 
+
+86
+00:07:32,440 --> 00:07:36,020
+كامل؟ سميناها كامل هنا لأن يُحتمل أن يكون الإضغام 
+
+87
+00:07:36,020 --> 00:07:41,000
+الذي ضا إضغام إذا اعتبرنا أن الغنة الناتجة هي من 
+
+88
+00:07:41,000 --> 00:07:45,480
+النون الكلمة المضغمة فيه يعني إذا اعتبرنا أن الغنة 
+
+89
+00:07:45,480 --> 00:07:50,420
+التي تظهر عندما نقول مثلًا ومن عمرهم هي من النون 
+
+90
+00:07:50,420 --> 00:07:55,170
+الأولى أه يعني إذا اعتبرنا أنه الـ الـ الإضغام 
+
+91
+00:07:55,170 --> 00:07:59,810
+يدخل النون مع الحرف الذي يليه إما يكون إضغام كامل 
+
+92
+00:07:59,810 --> 00:08:04,650
+أو إضغام ناقص إما أن النون كلها ذاتها وصفاتها تدخل 
+
+93
+00:08:04,650 --> 00:08:08,930
+في الحرف الثاني بنسمي إضغام كامل فهنا في قوله مثلًا 
+
+94
+00:08:08,930 --> 00:08:16,390
+ومن عمره طبعًا تدخل النون الأولى ذاتها وصفاتها ومن 
+
+95
+00:08:16,390 --> 00:08:20,950
+في الحرف الذي يليها طب الغنة التي ظاهر هذه هل تتبع 
+
+96
+00:08:20,950 --> 00:08:24,450
+النون الأولى ولا تتبع النون الثانية؟ تتبع النون 
+
+97
+00:08:24,450 --> 00:08:27,870
+الثانية عشان تتبع النون الثانية نقول أن النون 
+
+98
+00:08:27,870 --> 00:08:32,590
+الأولى دخلت ذاتها وصفاتها في النون الثانية فنسميه 
+
+99
+00:08:32,590 --> 00:08:38,190
+كامل على الراجح يعني العلماء يعني رجحه أن يكون 
+
+100
+00:08:38,190 --> 00:08:42,750
+الإضغام كاملًا مع الواو والياء على أساس أن النون 
+
+101
+00:08:42,750 --> 00:08:48,670
+الأولى مثل كلمة ومن نعمره النون الأولى دخلت ذاتها 
+
+102
+00:08:48,670 --> 00:08:52,830
+وصفاتها في النون الثانية والغنة التي تظهر هنا هي 
+
+103
+00:08:52,830 --> 00:08:56,810
+غنة النون الثانية وليست غنة النون الأولى هذا على 
+
+104
+00:08:56,810 --> 00:09:01,720
+اعتبار أنها كاملة أما لما بعض العلماء قالوا ناقصة 
+
+105
+00:09:01,720 --> 00:09:07,380
+فقالوا أن ومن نعمره الغنة التي تظهر هي غنة النون 
+
+106
+00:09:07,380 --> 00:09:13,960
+الأولى فدخلت ذاتها وبقيت صفاتها فصارت ناقصة إذا 
+
+107
+00:09:13,960 --> 00:09:20,120
+الإضغام مع الواو والياء إضغام أو مع ميم والنون 
+
+108
+00:09:20,120 --> 00:09:25,670
+إضغام كامل على الراجح قول العلماء أنها ممكن تكون 
+
+109
+00:09:25,670 --> 00:09:28,770
+النون الأولى ذاتها وصفاتها دخلت في النون الثانية 
+
+110
+00:09:28,770 --> 00:09:34,110
+أو قالوا إضغام ناقص على أساس أن النون الأولى دخلت 
+
+111
+00:09:34,110 --> 00:09:41,130
+ذاتها وبقيت صفاتها لذا قسمنا ناقص وأيهما أرجح كامل 
+
+112
+00:09:41,130 --> 00:09:45,670
+ولا ناقص الذي هو كامل على الراجح كما رجحه العلماء 
+
+113
+00:09:45,670 --> 00:09:50,330
+احنا قلنا ما هو السبب بالإضغام مع النون التماثل نون 
+
+114
+00:09:50,330 --> 00:09:54,030
+وعلى النون سبب الإضغام مع الميم التجانس لماذا 
+
+115
+00:09:54,030 --> 00:09:55,170
+متجانسة؟
+
+116
+00:09:58,050 --> 00:10:01,770
+يبقى مشترك في الصفات واختلافها في المخارج فمخرج 
+
+117
+00:10:01,770 --> 00:10:04,710
+النون يخرج من طرف اللسان مع لثة الثنائي العليا 
+
+118
+00:10:04,710 --> 00:10:09,330
+ومخرج الميم يخرج من الشفتين فاختلافهم في المخارج 
+
+119
+00:10:09,330 --> 00:10:13,450
+واتفاقهما في الصفات أما بالنسبة مع باقي الحروف 
+
+120
+00:10:13,450 --> 00:10:18,010
+الإضغام الذي هو التقارب إذا النون مع النون تماثل 
+
+121
+00:10:18,010 --> 00:10:23,090
+النون مع الميم تجانس النون مع باقي الحروف يسمى 
+
+122
+00:10:23,090 --> 00:10:29,140
+تقارب أنهينا موضوع الإضغام وهو الحكم الأول من أحكام 
+
+123
+00:10:29,140 --> 00:10:32,360
+النون الساكنة والتنوين ننتقل إلى الحكم الثاني يا 
+
+124
+00:10:32,360 --> 00:10:35,740
+أخوات وهو الإقلاب ما معنى الإقلاب لغة؟ 
+
+125
+00:10:38,870 --> 00:10:43,150
+نعم الإقلاب من حيث اللغة تحويل الشيء عن وجهه قلبت 
+
+126
+00:10:43,150 --> 00:10:47,890
+الكتابة أو حولته بعني حولته وفي الاصطلاح تحويل 
+
+127
+00:10:47,890 --> 00:10:52,290
+النون الساكنة أو التنوين إلى ميم مخففة مع مراعاة 
+
+128
+00:10:52,290 --> 00:10:56,650
+الغنة إذا جاء بعدها حرف الباء يعني إذا جاءت النون 
+
+129
+00:10:56,650 --> 00:11:01,170
+الساكنة أو التنوين وجاء بعدها حرف الباء تُقلب النون 
+
+130
+00:11:01,170 --> 00:11:07,400
+الساكنة إلى ميم مخففة إذا جاء بعد حرف الباء إذا 
+
+131
+00:11:07,400 --> 00:11:14,200
+الأمور التي يتحقق معها الإقلاب ثلاثة تأخذ من نفس 
+
+132
+00:11:14,200 --> 00:11:18,520
+التعريف أول شيء تحويل النون الساكنة أو التنوين إلى 
+
+133
+00:11:18,520 --> 00:11:25,170
+ميم النون أو التنوين تُقلب إلى ميم والميم التي بعدها 
+
+134
+00:11:25,170 --> 00:11:30,130
+باء تُخفف معها ومع مراعاة الغنة إذا قلب النون 
+
+135
+00:11:30,130 --> 00:11:35,690
+الساكن أو التنوين ميمًا مخففة إذا جاء بعدها حرف 
+
+136
+00:11:35,690 --> 00:11:42,750
+الباء مع مراعاة الغنة علامة الإقلاب يا أخوات في 
+
+137
+00:11:42,750 --> 00:11:50,110
+المصحف الميم المعكوفة أو ميم بذنبة تختلف الميم 
+
+138
+00:11:50,110 --> 00:11:56,410
+المعكوفة عن الميم الأفقية الميم الأفقية هي رمز 
+
+139
+00:11:56,410 --> 00:12:02,290
+للوقف اللازم لكن الميم المعكوفة أو الميم التي لها 
+
+140
+00:12:02,290 --> 00:12:06,760
+ذنبة هي للإقلاب والأمثلة على ذلك يعني متعددة و 
+
+141
+00:12:06,760 --> 00:12:11,120
+كثيرة والغرض يا أخوات أو سبب الإقلاب هو السهولة
+
+142
+00:12:11,120 --> 00:12:15,200
+سهولة النطق بالحرف الذي بعدها بـاء لأن في بينهم
+
+143
+00:12:15,200 --> 00:12:19,500
+عوامل مشتركة أما بالنسبة للأمثلة فعندنا العديد من
+
+144
+00:12:19,500 --> 00:12:24,420
+الأمثلة نرى يعني أنها تقلب من نون إلى ميم من يقرأ 
+
+145
+00:12:24,420 --> 00:12:32,420
+المثال الأول ويطبق الحكم؟ من بعد الحكم
+
+146
+00:12:32,420 --> 00:12:33,220
+الثاني؟
+
+147
+00:12:35,810 --> 00:12:41,890
+سميعا بصيرا إذا النون قلبت إلى ميم أو التنوين تقلب 
+
+148
+00:12:41,890 --> 00:12:47,070
+إلى ميم والميم مع الباء أخفي عشان جاء وراها حرف
+
+149
+00:12:47,070 --> 00:12:52,390
+الباء قلب النون الساكنة ميما مخفيا إذا جاء وراها حرف
+
+150
+00:12:52,390 --> 00:12:58,010
+الباء فهنا سميعا بصيرا كذلك أنبئهم كيف نقرأها يا
+
+151
+00:12:58,010 --> 00:13:10,800
+أخوات؟ فضلا أنبئهم طيب فانبئسهم كيف تقرأ؟ ينبئ
+
+152
+00:13:10,800 --> 00:13:19,500
+كيف نقرأها؟ ينبئهم كذلك أنبُرك 
+
+153
+00:13:21,290 --> 00:13:29,510
+كيف نقرأها؟ ماذا فعلنا؟ قلبنا النون الساكنة إلى ميم
+
+154
+00:13:29,510 --> 00:13:34,830
+مخفيا لأنه جاء وراء حرف النون الساكنة حرف الباء مع
+
+155
+00:13:34,830 --> 00:13:39,790
+مراعاة الغنة أنهينا الإقلاب يعني الإقلاب قلب النون
+
+156
+00:13:39,790 --> 00:13:44,990
+الساكنة ميما مخفيا مع مراعاة الغنة إذا جاء وراها
+
+157
+00:13:44,990 --> 00:13:50,880
+حرف الباء وهذا موجود بكثرة في القرآن الكريم الحكم
+
+158
+00:13:50,880 --> 00:13:54,840
+الثالث وهو حكم... الحكم الرابع هو حكم الإخفاء
+
+159
+00:13:54,840 --> 00:13:59,920
+ويسمى الإخفاء الحقيقي حتى نفرق ما بينه وبين
+
+160
+00:13:59,920 --> 00:14:05,820
+الإخفاء الشفوي والإخفاء يا أخوات لغة الستر أخفيت
+
+161
+00:14:05,820 --> 00:14:11,280
+الشيء بمعنى سترته عن الأعين والإخفاء استعارة من
+
+162
+00:14:11,280 --> 00:14:15,140
+يعني يعرف لنا الإخفاء من حيث الاستعارة فضلي
+
+163
+00:14:21,100 --> 00:14:24,860
+أحسنتي إذا النطق بالحرف المخفي طبعا وهو النون
+
+164
+00:14:24,860 --> 00:14:28,980
+بالنسبة للحكم الذي عندنا النطق بالحرف المخفي بصفة
+
+165
+00:14:28,980 --> 00:14:33,860
+ما بين الإظهار والإدغام عارفين عن التجديد مع مراعاة
+
+166
+00:14:33,860 --> 00:14:39,420
+الغنة يعني إعطاء صفة للنون الساكنة أو التنوين ما
+
+167
+00:14:39,420 --> 00:14:44,560
+بين الإظهار والإدغام إذا جاء وراها أي حرف من حروف
+
+168
+00:14:44,560 --> 00:14:48,930
+الإخفاء فما هي حروف الإخفاء؟ حروف الإخفاء يا أخوات
+
+169
+00:14:48,930 --> 00:14:52,670
+وايد فضلي؟ بجمعها في أول البيت اللي هو يقول صفّت 
+
+170
+00:14:52,670 --> 00:14:58,730
+ثاني كفجل شخص قد سمع دم طيب نزل فيه طبخبايت هنا صفّ
+
+171
+00:14:58,730 --> 00:15:04,810
+ذاثنى كمجاد شخص قد سمى ضم طيبا زد في طقن ضع ظالمة
+
+172
+00:15:04,810 --> 00:15:10,710
+أول حرف من كل كلمة إذا جاء هذا الحرف بعد النون
+
+173
+00:15:10,710 --> 00:15:16,870
+الساكنة أو التنوين بيعطيه صفة ما بين الإظهار
+
+174
+00:15:16,870 --> 00:15:23,090
+والإدغام مثل ذلك عندنا أمثلة متعددة 15 حرف هذولا
+
+175
+00:15:23,090 --> 00:15:29,240
+15 كلمة 15 حرف وقلنا إن أحكام النون الساكنة متقسمة
+
+176
+00:15:29,240 --> 00:15:34,220
+على الإظهار والإدغام والإقلاب والإخفاء الإظهار له
+
+177
+00:15:34,220 --> 00:15:38,360
+كم حرف؟ ستة حروف وهي الهمزة والهاء والعين والحاء
+
+178
+00:15:38,360 --> 00:15:42,830
+والغين والخاء الإقلاب حرف هيصهاره سبعة وكذلك
+
+179
+00:15:42,830 --> 00:15:48,110
+الإدغام 6 أحرف هي سنة و 13 مجموعة في قوله يرملون
+
+180
+00:15:48,110 --> 00:15:54,110
+13 حرف باقي الحروف 15 حرف مجموعة في قوله صفد ثنى
+
+181
+00:15:54,110 --> 00:15:59,870
+كمجاد شخص قد سمى دم طيبا زد في تقن بعظلمة عندنا
+
+182
+00:15:59,870 --> 00:16:05,750
+أمثلة على الإخفاء من يقرأ المثال الأول أنصدوكم كيف
+
+183
+00:16:05,750 --> 00:16:08,850
+نقرأها مع تطبيق الإخفاء فضلي
+
+184
+00:16:11,240 --> 00:16:16,560
+أصدوكم إذا النون تُعطى صفة لا هي إظهار ولا هي
+
+185
+00:16:16,560 --> 00:16:20,940
+إدغام بل ما بين الإظهار والإدغام لأن الحرف الذي
+
+186
+00:16:20,940 --> 00:16:25,320
+جاء وراء بعدها حرف الصاد وهو من حروف الإخفاء لو
+
+187
+00:16:25,320 --> 00:16:29,350
+قلنا يا أخوات ما هو الحرف الذي يحكم على النون
+
+188
+00:16:29,350 --> 00:16:33,590
+الساكنة بالإظهار أو الإدغام أو الإقلاب أو الإخفاء؟
+
+189
+00:16:33,590 --> 00:16:37,450
+الحرف الذي يليه إذا كان الحرف الذي يليه من حروف
+
+190
+00:16:37,450 --> 00:16:41,750
+الإظهار يحكم على النون بالإظهار وإذا كان الحروف
+
+191
+00:16:41,750 --> 00:16:45,650
+الإدغام بيحكم على النون الساكنة بالإدغام وإذا كان
+
+192
+00:16:45,650 --> 00:16:50,430
+حرف الباء بيحكم على النون الساكنة بالإقلاب وإذا لم
+
+193
+00:16:50,430 --> 00:16:53,670
+يكن أي حرف من هذه الحروف بيكون من حروف الإخفاء
+
+194
+00:16:53,670 --> 00:16:57,790
+بيحكم على النون الساكنة بالإخفاء يعني نعطي النون
+
+195
+00:16:57,790 --> 00:17:03,270
+الساكنة صفة ما بين الإظهار والإدغام مثلا أنصدوكم
+
+196
+00:17:03,270 --> 00:17:08,110
+اللي هي قوله صف ذا ثنى كم جاد شخص قد سمى إلى نهيت
+
+197
+00:17:08,110 --> 00:17:16,510
+البيت حرف الصاد صف مثلا مثلأ صدوكم ونجد أنه 
+
+198
+00:17:16,510 --> 00:17:21,650
+لابد أن نحقق الغنة والغنة كما قلنا اللي هي صوت
+
+199
+00:17:21,650 --> 00:17:25,490
+جميل يعني صفة ملازمة من الـميم والنون يخرج من
+
+200
+00:17:25,490 --> 00:17:30,910
+الخيشوم مقدر وحركتين نقول أصدوكم طيب لو كان 
+
+201
+00:17:30,910 --> 00:17:36,750
+أخوات واحد أو واحدة عندها مرشحة أو مزاكمة مغلق
+
+202
+00:17:36,750 --> 00:17:42,090
+أنفة هل تخرج الغنة بشكل واضح؟ لا تخرج يعني مثلا لو
+
+203
+00:17:42,090 --> 00:17:46,730
+أغلقنا الأنف وقولنا أنصدوكم لا يخرج... لا تخرج
+
+204
+00:17:46,730 --> 00:17:51,270
+الحرف بشكل مريح أنصدوكم أنصدوك... يعني مغلقة لا
+
+205
+00:17:51,270 --> 00:17:59,970
+تخرج وبالتالي أصدوكم دي هنصرصر على كيف نقرأها ريحة 
+
+206
+00:17:59,970 --> 00:18:07,350
+صرصرة... ريحة صرصرة... الأنصار... الأنصار...
+
+207
+00:18:07,350 --> 00:18:15,710
+الانصار طيب حرف الذال مثلا إن ذكرتم كيف نقرأها؟ من 
+
+208
+00:18:15,710 --> 00:18:24,200
+يقرأ؟ فضلا أَإِن ذُكِّرْتُم أَإِن ذُكِّرْتُم أو من
+
+209
+00:18:24,200 --> 00:18:29,380
+ذَ الَّذِي من ذَ الَّذِي كذلك خليني أقول 
+
+210
+00:18:29,380 --> 00:18:34,200
+أأنذرتهم أأنذرتهم 
+
+211
+00:18:34,200 --> 00:18:41,220
+أأنذرتهم حرف ثاء من ثمرة كيف نقرأها كلمة من ثمرة
+
+212
+00:18:41,220 --> 00:18:50,700
+تفضلي من ثمرة... من ثمرة... طيب قولا ثقيلة... قولا
+
+213
+00:18:50,700 --> 00:19:01,510
+ثقيلة... قولا ثقيلة... أَن كَانَ أَن كَانَ كتاب كريم كتاب
+
+214
+00:19:01,510 --> 00:19:13,350
+كريم ينكثون ينكثون ومن جاهد ومن جاهد فصبر جميل
+
+215
+00:19:13,350 --> 00:19:21,700
+فأنجينا إن شاء وهكذا نطبق حكم الإخفاء إذا جاء نون
+
+216
+00:19:21,700 --> 00:19:25,860
+ساكنة وجاء بعدها أي حرف من حروف الإخفاء المجموعة
+
+217
+00:19:25,860 --> 00:19:31,760
+في قوله صف ذا ثنى كوجهد شخص قد سمى ضم طيبا زد فيه
+
+218
+00:19:31,760 --> 00:19:37,270
+تقن ضع ظالمة إذا هناك فرق يا أخوات ما بين هذه الأحكام
+
+219
+00:19:37,270 --> 00:19:43,110
+إظهار إدغام إقلاب إخفاء ما هو الحرف الذي يحكم
+
+220
+00:19:43,110 --> 00:19:47,190
+على النون الساكنة بهذه الأحكام؟ الحرف الذي يليها،
+
+221
+00:19:47,190 --> 00:19:49,530
+إذا كان الحرف الذي يليها من حروف أخواتها كعلم
+
+222
+00:19:49,530 --> 00:19:52,710
+أنحاسها وغيره خاتري، أول حرف من كل كلمة، بيحكم
+
+223
+00:19:52,710 --> 00:19:57,840
+عليها بالإظهار لو كان حرف يرملون إدغام لو كان حرف
+
+224
+00:19:57,840 --> 00:20:01,720
+الباء إقلاب لو لم يكن أي حرف من هذه الحروف بيكون
+
+225
+00:20:01,720 --> 00:20:05,760
+من باقي الأحرف وهو بيكون عندنا إخفاء لكن ما
+
+226
+00:20:05,760 --> 00:20:12,580
+الفرق ما بين الإدغام والإخفاء؟ ما رأيكم؟ فضلي
+
+227
+00:20:16,700 --> 00:20:21,320
+أحسنت الفرق الأول أن الإدغام يكون في الحرف الذي
+
+228
+00:20:21,320 --> 00:20:27,100
+بعده يعني في نفس الحرف نجد أن نضغم النون نضغم في
+
+229
+00:20:27,100 --> 00:20:32,520
+ذات الحرف اللي هي مثلا نقول ما يعمل النون أضغمت
+
+230
+00:20:32,520 --> 00:20:37,000
+في جلب الحرف في ذات الحرف أو مثلا ما أقول من واق 
+
+231
+00:20:37,000 --> 00:20:44,060
+من واق من مال من مال إذا النون أضغمت وأدخلت في
+
+232
+00:20:44,060 --> 00:20:48,540
+ذات الحرف لكن بالنسبة لحروف الإخفاء فنجد أن النون
+
+233
+00:20:48,540 --> 00:20:53,280
+لا تضغم في ذات الحرف وإنما يعني بتكون عند الحرف
+
+234
+00:20:53,280 --> 00:21:01,870
+نقول الإنسان بجسين طول فضل ما صلصال الحرف اللي بعده
+
+235
+00:21:01,870 --> 00:21:07,890
+يعني ينفذ رسمي لكن التي تخفى هي حرف النون نقول مي
+
+236
+00:21:07,890 --> 00:21:16,170
+سلسال ماذا الذي؟ أين ذكرتم؟ الفرق الأول أن
+
+237
+00:21:16,170 --> 00:21:20,390
+الإدغام يكون في الحرف الذي يليه أما بالنسبة
+
+238
+00:21:20,390 --> 00:21:24,550
+للإخفاء يكون عند الحرف الذي يليه طيب الفرق الثاني
+
+239
+00:21:24,550 --> 00:21:25,470
+يا أخوات فضلي
+
+240
+00:21:29,370 --> 00:21:34,050
+أحسنتي في الإدغام يا أخوات يشدد الحرف الثاني نقول 
+
+241
+00:21:34,050 --> 00:21:40,870
+ما يعمل من مال من نعمة نجد أن الحرف الثاني يوضع عليه
+
+242
+00:21:40,870 --> 00:21:46,330
+شدة في الإدغام أما في الإخفاء فلا يعني شدد وإنما
+
+243
+00:21:46,330 --> 00:21:53,750
+يذكر كما هو فنقول الارثان مضموم ما الذي وهكذا
+
+244
+00:21:53,750 --> 00:21:58,190
+الفرق الثالث فضل أخت أنت نعم
+
+245
+00:22:02,130 --> 00:22:05,770
+الإدغام لا يكون إلا في كلمتين طب لو وقع الإدغام
+
+246
+00:22:05,770 --> 00:22:10,750
+في كلمة واحدة لا يكون إدغاما وإنما نسميه الإظهار
+
+247
+00:22:10,750 --> 00:22:15,290
+المطلق إذا الإدغام يجب أن يكون في كلمتين أما
+
+248
+00:22:15,290 --> 00:22:20,620
+بالنسبة للإخفاء يقع في كلمة ويقع في كلمتين هنا يا
+
+249
+00:22:20,620 --> 00:22:26,020
+أخوات أحكام النون الساكنة والتنوين ننتقل إلى أحكام
+
+250
+00:22:26,020 --> 00:22:30,380
+الميم الساكنة الميم الساكنة يا أخوات يعني كما
+
+251
+00:22:30,380 --> 00:22:35,000
+نقول نون ساكنة قولنا هنقول الميم الساكنة يعني
+
+252
+00:22:35,000 --> 00:22:39,080
+الميم التي هي لا حركة لها خالية من الحركات والتي
+
+253
+00:22:39,080 --> 00:22:44,370
+سكونها ثابت في الوصل والوقف إذا وصلنا الكلمة نسكنها
+
+254
+00:22:44,370 --> 00:22:49,070
+وإذا وقفنا عليها حرف الميم أيضا يسكن فالميم
+
+255
+00:22:49,070 --> 00:22:53,590
+الساكنة هي الميم التي لا حركة لها والتي سكونها
+
+256
+00:22:53,590 --> 00:23:00,270
+ثابت في الوقف والوصل مثل كلمة أنعمت لو قلنا مثلا
+
+257
+00:23:00,270 --> 00:23:04,090
+كلمة أنعمت ما هي الأحكام الموجودة في أنعمت من
+
+258
+00:23:04,090 --> 00:23:07,130
+الأحكام التي أخذناها نحن قبل قليل فضلي
+
+259
+00:23:10,840 --> 00:23:14,940
+أحسنتي في عينينا حكمين وكلاهما إظهار لكن واحد اسمه
+
+260
+00:23:14,940 --> 00:23:19,580
+إظهار حلقي نون وراء حرف العين وحرف العين من حروف
+
+261
+00:23:19,580 --> 00:23:24,140
+الإظهار الحلقي والحكم الثاني الميم والتاء الميم
+
+262
+00:23:24,140 --> 00:23:28,360
+ساكنة وبعد حرف التاء حرف التاء بيحكم على الميم
+
+263
+00:23:28,360 --> 00:23:34,580
+الساكنة بالإظهار فنقول أنعمت أنعمت النون ها النون
+
+264
+00:23:34,580 --> 00:23:40,300
+تظهر أنعمت والميم أيضا تظهر ما هي الحرف التي حكمت
+
+265
+00:23:40,300 --> 00:23:44,220
+عليها بالإظهار سواء النون ولا الميم الحرف اللي
+
+266
+00:23:44,220 --> 00:23:48,920
+يليها ففي قوله أنعمت العين حكمت على النون بالإظهار
+
+267
+00:23:48,920 --> 00:23:53,990
+والتاء حكمت على الميم أيضا بالإظهار ويخرجوا من
+
+268
+00:23:53,990 --> 00:23:58,250
+الميم الساكنة الميم المتحركة نتيجة التخلص من
+
+269
+00:23:58,250 --> 00:24:01,670
+التقاء الساكنين في عندنا حكم من الأحكام هناخده
+
+270
+00:24:01,670 --> 00:24:04,610
+مستقبلا إن شاء الله اللي هو التخلص من التقاء
+
+271
+00:24:04,610 --> 00:24:09,010
+الساكنين إذا جاء حرفين ساكنين متتالين في كلمتين
+
+272
+00:24:09,440 --> 00:24:14,400
+نتخلص من هما إما بالحذف لو كان الساكن الأول حرف مد
+
+273
+00:24:14,400 --> 00:24:19,460
+وإما بالتحريك بالكسرة أو بالفتحة أو بالضمة حسب
+
+274
+00:24:19,460 --> 00:24:25,480
+موقعها لو تخلصنا من التقاء الساكنين بالتحريك نشوف
+
+275
+00:24:25,480 --> 00:24:32,000
+هنا مثلا وأنتم الأعلوم وأنتم الأعلون أصلا الميم
+
+276
+00:24:32,000 --> 00:24:36,480
+بتاعة أنتم ساكنة وأنتم الأعلون واللام بتاعة
+
+277
+00:24:36,480 --> 00:24:42,080
+الأعلون ساكنة فهنا في عينينا حرفين ساكنين اللي هو
+
+278
+00:24:42,080 --> 00:24:47,420
+حرف الميم وأنتم الأعلون اللام ساكنة عند الوصل
+
+279
+00:24:47,420 --> 00:24:52,800
+نتخلص من التقاء الساكنين نقول وأنتموا الأعلون و
+
+280
+00:24:52,800 --> 00:25:00,340
+أنتموا حركنا الميم بالضمة لأن الميم الجماعة لو
+
+281
+00:25:00,340 --> 00:25:03,460
+جاءت يعني حرفين ساكنين وكانت الميم الأولى ميم
+
+282
+00:25:03,460 --> 00:25:07,760
+الجماعة نتخلص من التقاء الساكنين بالضم فنقول و
+
+283
+00:25:07,760 --> 00:25:14,880
+أنتموا و أنتموا الأعلون هي أصلا و أنتم الأعلون لكن
+
+284
+00:25:14,880 --> 00:25:20,540
+ثقيلة على اللسان أن نقول و أنتم الأعلون في القراءة
+
+285
+00:25:21,010 --> 00:25:26,570
+لذلك نتخلص من التقاء الساكنين بالتحريك بالضمة عشان
+
+286
+00:25:26,570 --> 00:25:32,770
+ميم الجماعة فنقول و أنتم الأهلون كذلك في قوله هم
+
+287
+00:25:32,770 --> 00:25:38,710
+العدو هم العدو ثقيل على اللسان أن نقول هم العدو
+
+288
+00:25:38,710 --> 00:25:44,910
+ماذا نقول هم العدو فاحضرهم هم العدو فاحضرهم من باب
+
+289
+00:25:44,910 --> 00:25:48,590
+الخفة على اللسان يعني نتيجة أن الميم ساكنة بتاعتهم
+
+290
+00:25:49,020 --> 00:25:54,700
+والعدو اللام ساكنة نتخلص من التقاء الساكنين بالضم
+
+291
+00:25:54,700 --> 00:26:00,620
+هم العدو فاحضرهم كذا جاءت قوله قم الليل فقيلة أن
+
+292
+00:26:00,620 --> 00:26:06,000
+نقول قم الليل إلا قليلا فنتخلص من التقاء الساكنين
+
+293
+00:26:06,000 --> 00:26:12,400
+بالكثرة لأن الميم هنا ليست ميم الجماعة ليست مثل
+
+294
+00:26:12,400 --> 00:26:17,980
+كلمة هم إنما هي قم أنت من نفس الكلمة نقول قم الليل
+
+295
+00:26:17,980 --> 00:26:24,640
+إلا قليلا قميه بالكثرة قم الليل إلا قليلا كذلك
+
+296
+00:26:24,640 --> 00:26:30,420
+قوله أم ارتابهام ارتابوا ميم ساكنة وراها الهمزة
+
+297
+00:26:30,420 --> 00:26:34,540
+الكثير ارتابوا أو الراء .. الراء ساكنة نتخلص من
+
+298
+00:26:34,540 --> 00:26:39,960
+التقاء الساكنين نقول امرتابوا امرتابوا طيب الهمزة
+
+299
+00:26:39,960 --> 00:26:45,790
+الموجودة هنا ارتابوا همزة إيش هذه؟ همزة الوصل في
+
+300
+00:26:45,790 --> 00:26:49,990
+حالة الوصل تسقط لكن إذا ابتدأنا بها الكلام نقول
+
+301
+00:26:49,990 --> 00:26:56,370
+ارتبوا لكن إذا وصلناها نقول امرتبوا يعني نجد أن
+
+302
+00:26:56,370 --> 00:27:01,930
+همزة الوصل سقطت فالحرفين الحرفان الساكنان هما الرأى
+
+303
+00:27:01,930 --> 00:27:06,450
+أو ال ميم الساكنة والراء الساكنة نقول أمرتابو هذه
+
+304
+00:27:06,450 --> 00:27:11,210
+أخوات بالنسبة للميم المتحركة نتيجة أو أنه أصلا
+
+305
+00:27:11,210 --> 00:27:15,010
+ساكنة لكن لأنه بدنا نتخلص منها نتخلص من الاتقاء
+
+306
+00:27:15,010 --> 00:27:20,750
+الساكنين بالتحريك لأن معاملها معاملة الميم الساكنة
+
+307
+00:27:20,750 --> 00:27:26,790
+حكم الميم الساكنة لها تلت أحكام شبيهة بأحكام النون
+
+308
+00:27:26,790 --> 00:27:30,250
+الساكنة والتنوين اللي هي الإضغام الشفوي والإخفاء
+
+309
+00:27:30,250 --> 00:27:36,350
+الشفوي والإظهار الشفوي نأتي إلى الحكم الأول من
+
+310
+00:27:36,350 --> 00:27:41,450
+أحكام ال ميم الساكنة وهو الإضغام الشفوي لماذا
+
+311
+00:27:41,450 --> 00:27:46,810
+سميناها شفوي يا أخوات؟ لأن الميم تخرج من الشفتين
+
+312
+00:27:47,470 --> 00:28:02,130
+نقول ام ام ام
+
+313
+00:28:02,130 --> 00:28:02,170
+ام ام ام ام ام ام ام ام ام ام ام ام ام ام ام ام ام
+
+314
+00:28:02,170 --> 00:28:02,690
+ام ام ام ام ام ام ام ام ام ام ام ام ام ام ام ام
+
+315
+00:28:02,690 --> 00:28:12,310
+ام ام ام ام ام
+
+316
+00:28:12,310 --> 00:28:18,750
+اميعني إذا جاء حرف الميم الساكنة وجاء وراها الميم
+
+317
+00:28:18,750 --> 00:28:24,210
+المتحركة تضغم الميم الساكنة في الميم المتحركة بحيث
+
+318
+00:28:24,210 --> 00:28:29,950
+يصيران في النطق كأنهما ميما واحدة مشددة وهي هذا ما
+
+319
+00:28:29,950 --> 00:28:34,770
+يسمى أيضا له اسم آخر وهو إضغام المثلين الصغير أو
+
+320
+00:28:34,770 --> 00:28:39,910
+المثلين الصغير لأن الميم تماثل الميم الميم الساكنة
+
+321
+00:28:40,980 --> 00:28:46,240
+تشبه وتماثل الميم المتحركة فتضغم الميم الساكنة في
+
+322
+00:28:46,240 --> 00:28:50,380
+الميم المتحركة بحيث يصيراني ميما واحدة مشددة
+
+323
+00:28:50,380 --> 00:28:56,080
+نسميها نحن حسب حكمنا الآن إضغام شفوي لكن هي نفسها
+
+324
+00:28:56,080 --> 00:29:01,960
+يطلق عليها متماثلين صغير لأن الميم تماثل الميم سبب
+
+325
+00:29:01,960 --> 00:29:06,300
+الإضغام يا أخوات هو التماثل ما بين الميم والميم
+
+326
+00:29:06,300 --> 00:29:12,660
+ويكون إضغامه كما أنه في الكلمات زي مثلا لهم ما
+
+327
+00:29:12,660 --> 00:29:19,140
+يشاءون كيف نقرأها لهم ما يشاءون تضغم الميم الأولى
+
+328
+00:29:19,140 --> 00:29:25,400
+بالميم الثانية لهم ما يشاءون طيب لكن كذلك بتكون في
+
+329
+00:29:25,400 --> 00:29:29,700
+الحروف الهجائية التي استفتح الله بها العديد من
+
+330
+00:29:29,700 --> 00:29:32,840
+الصور القرأنية مثل الف ل
+
+331
+00:29:39,990 --> 00:29:49,950
+الميم بتاعة لم تضغم بالميم بتاعة ميم هنا ألف لم
+
+332
+00:29:49,950 --> 00:29:53,730
+ميم
+
+333
+00:29:53,730 --> 00:29:59,110
+وهذا ما نصميه بالمادة اللي لازم نقشها مد لازم حرفي
+
+334
+00:29:59,110 --> 00:30:04,170
+ولا كلمي؟ مد لازم حرفي مثقل لو كانت الحرف الأول
+
+335
+00:30:04,170 --> 00:30:09,250
+ساكن واضغم مع الحرف الذي يليه أو مخفف لو كان ساكن
+
+336
+00:30:09,250 --> 00:30:15,570
+فقط يعني هنا مثلا لو سألنا سؤال قلنا كم صورة
+
+337
+00:30:15,570 --> 00:30:21,780
+مستفتحة بحروف الهجائية؟ كم صورة استفتحت بحروف
+
+338
+00:30:21,780 --> 00:30:25,900
+الهجائية؟ مثلا ألف لام ميم، ألف لام ميم را، كاف ها
+
+339
+00:30:25,900 --> 00:30:31,080
+يا عين صاد، نون، صاد، قاف، من هذه الحروف كم صورة
+
+340
+00:30:31,080 --> 00:30:35,320
+في القرآن استفتحت بحروف الهجائية؟ ما رأيكم؟
+
+341
+00:30:39,220 --> 00:30:43,060
+تسعة وعشرون صورة الحروف اللي استفتحت بحروف هجائية
+
+342
+00:30:43,060 --> 00:30:47,760
+تسعة وعشرون صورة طيب عدد الحروف الهجائية اللي
+
+343
+00:30:47,760 --> 00:30:51,760
+استفتحت بها الصور القرآنية لو جمعنا الحروف ألف
+
+344
+00:30:51,760 --> 00:30:56,860
+لام ميم و كفها يا عين صاد و نون و صاد و حاميم من هذه
+
+345
+00:30:56,860 --> 00:31:01,700
+الحروف هنجدها نصف حروف اللغة العربية كم حروف
+
+346
+00:31:01,700 --> 00:31:08,370
+اللغة العربية؟ 28 حرف نصفها 14 حرفا مجموعة في قوله
+
+347
+00:31:08,370 --> 00:31:14,890
+نص حكيم له سر قاطع إذا 14 حرف مجموعة في قوله نص
+
+348
+00:31:14,890 --> 00:31:19,530
+حكيم له سر قاطع هذه نصف حروف اللغة العربية وكذلك
+
+349
+00:31:19,530 --> 00:31:23,470
+من إعجاز القرآن أنها نصف صفات الحروف اللغة العربية
+
+350
+00:31:23,470 --> 00:31:28,110
+وهذا كله إعجاز بالنسبة للقرآن الكريم إذا جاء أي
+
+351
+00:31:28,110 --> 00:31:34,740
+حرف من الحروف الهجائية في أوائل الصور ميم وكان قبلها
+
+352
+00:31:34,740 --> 00:31:39,340
+ميم ساكنة تضغم الميم الساكنة بالميم المتحركة بحيث
+
+353
+00:31:39,340 --> 00:31:44,900
+يصيران ميما واحدة مشددة كما قلنا في هذا المثال ألف
+
+354
+00:31:44,900 --> 00:31:49,840
+لا ميم كيف نقرأ هذه أخوات؟ من يقرأ هذه الألف لا
+
+355
+00:31:49,840 --> 00:31:51,200
+ميم؟
+
+356
+00:31:58,530 --> 00:32:00,530
+أحسنتي لكن تريد أن نزيد
+
+357
+00:32:07,780 --> 00:32:14,540
+ست حركات لأن هذا مد لازم حرفي مثقل في الميم الأولى
+
+358
+00:32:14,540 --> 00:32:20,720
+لم ميم مثقل لأنه جاء تحريف الهجاء لحرف لام مكوّن
+
+359
+00:32:20,720 --> 00:32:25,280
+من ثلاث حروف ل لام و ألف و ميم وسطها حرف مد وهو
+
+360
+00:32:25,280 --> 00:32:29,880
+الألف والميم مضغم مع الميم يعني كأنه حرف مد وجاء
+
+361
+00:32:29,880 --> 00:32:35,300
+ورا حرف مشدد من سميم مد لازم حرفي مثقل لكن الميم
+
+362
+00:32:35,300 --> 00:32:39,940
+لحالها م و إي و ام جاء حرف المد يعني جاء التحريف
+
+363
+00:32:39,940 --> 00:32:44,180
+الهجائي للحرف ميم مكوّن من 3 حروف الام واليا
+
+364
+00:32:44,180 --> 00:32:49,440
+والميم وسطها حرف مد وهو الياء وآخرها حرف ساكن ميم
+
+365
+00:32:49,440 --> 00:32:53,220
+نسميها مد لازم حرفي مخفف هناخده إن شاء الله في
+
+366
+00:32:53,220 --> 00:32:58,580
+حين هي عندما نأخذ الحروف المد اللازم المثقل سواء
+
+367
+00:32:58,580 --> 00:33:04,240
+cannie canny أو حرفين نعود لأمثلة أخوات، أمثلة
+
+368
+00:33:04,240 --> 00:33:11,160
+المتماثلين أو أمثلة الإضغام الشفوي، في قوله مثلا،
+
+369
+00:33:11,160 --> 00:33:19,520
+بإذن ربهم من كل أمر، من يقرأها؟ كيف تقرأ؟ بإذن ربهم
+
+370
+00:33:19,520 --> 00:33:28,040
+كل أمر أين الإضغام؟ الميم مع الميم ربهم من اضغمت
+
+371
+00:33:28,040 --> 00:33:32,440
+الميم الأولى ربهم في الميم الثانية اللي هي من
+
+372
+00:33:32,440 --> 00:33:39,480
+فصارت كأنهم ميما واحدة مشددة من جنس الثاني ربهم من
+
+373
+00:33:39,480 --> 00:33:47,240
+كذلك في قوله الذي أطعمهم من جوع الذي أطعمهم من جوع
+
+374
+00:33:47,240 --> 00:33:52,860
+أطعمهم من ميم الأولى أضغمت في الميم الثانية يعني
+
+375
+00:33:52,860 --> 00:33:57,020
+ميم ساكنة اللي هي أطعمهم والميم الثانية من متحرك
+
+376
+00:33:57,020 --> 00:34:01,900
+بالكسرة تضغم الميم الأولى في الميم الثانية بحيث
+
+377
+00:34:01,900 --> 00:34:06,680
+يصلاني ميما واحدة مشددة كذلك في قوله إن كنتم
+
+378
+00:34:06,680 --> 00:34:14,580
+مؤمنين إن كنتم مؤمنين الميم بتاعة كنتم ميم ساكنة
+
+379
+00:34:14,580 --> 00:34:20,740
+ورجع وراها مؤمنين الميم مضمومة تضغم الميم الساكنة
+
+380
+00:34:20,740 --> 00:34:28,060
+وهي كنتم بالميم المتحركة وهي مؤمنين فنقول إن كنتم
+
+381
+00:34:28,060 --> 00:34:34,590
+مؤمنين بحيث يصيراني ميما واحدة مشددة أو مثلا خلق
+
+382
+00:34:34,590 --> 00:34:42,950
+لكم ما في الأسماء خلق لكم ما أو لهم ما لهم ما ال
+
+383
+00:34:42,950 --> 00:34:47,650
+ميم بتاعة لهم بتضغم في الميم بتاعة ما فبتصير
+
+384
+00:34:47,650 --> 00:34:53,230
+كأنهما ميما واحدة مشددة ولكن يجب أن نحقق إيش أخوات
+
+385
+00:34:53,760 --> 00:34:59,460
+الغنّى لهم ما نحقق الغنّى لأن الميم مع الميم بيصير
+
+386
+00:34:59,460 --> 00:35:04,880
+ميم مشددة والميم المشددة طبعا تغنّى كما سوف نأخذها
+
+387
+00:35:04,880 --> 00:35:09,120
+الحكم الثالث يا أخوات من أحكام الميم الساكنة هو
+
+388
+00:35:09,120 --> 00:35:14,040
+الإخفاء الشفوي والإخفاء الشفوي معروف هو الستر
+
+389
+00:35:14,040 --> 00:35:19,760
+وحروف الإخفاء الشفوي حرف واحد وهو الباء إذا جاء بعد
+
+390
+00:35:19,760 --> 00:35:28,440
+الميم الساكنة حرف الباء تخفى الميم في الباء مع إثبات
+
+391
+00:35:28,440 --> 00:35:33,200
+ومراعاة الغنّى ويسمى إخفاء شفويا حتى نفرّق ما بين
+
+392
+00:35:33,200 --> 00:35:37,300
+الإخفاء الشفوي والإخفاء الحقيقي ويخرج من الشفتين
+
+393
+00:35:37,300 --> 00:35:42,820
+سبب الإخفاء ما بين الميم والباء اللي هو التجانس
+
+394
+00:35:42,820 --> 00:35:48,000
+الميم والباء اتفقا في المخرج الميم والباء مخرج من
+
+395
+00:35:48,000 --> 00:35:53,690
+واحد واختلفا في الصفات أمثلة على الإخفاء الشفوي
+
+396
+00:35:53,690 --> 00:36:01,370
+مثلا آمنتم بالله كيف نقرأها؟ نقرأها آمنتم بالله
+
+397
+00:36:01,370 --> 00:36:07,470
+نعطي الميم صفة ما بين الإظهار والإخفاء لا نضغمها
+
+398
+00:36:07,470 --> 00:36:15,590
+ولا نظهرها بل نسترها بمعنى أننا نخرج الميم بصّفة ما
+
+399
+00:36:15,590 --> 00:36:21,330
+بين الإظهار والإضغام مع مراعاة الغنّى فنقول أماتم
+
+400
+00:36:21,330 --> 00:36:29,970
+بالله هم بربهم هم بربهم هم بربهم ما يسمى بالإخفاء
+
+401
+00:36:29,970 --> 00:36:38,670
+كذلك إليهم بهدية إليهم بهدية كذلك إن كنتم بآياته
+
+402
+00:36:40,900 --> 00:36:53,460
+كنتم بآياته يوم هم بارزون، هم بارزون، هم بارزون،
+
+403
+00:36:53,460 --> 00:36:56,960
+هم
+
+404
+00:36:56,960 --> 00:36:59,380
+بارزون، هم بارزون، هم بارزون، هم بارزون، هم
+
+405
+00:36:59,380 --> 00:37:00,120
+بارزون، هم بارزون، هم بارزون، هم بارزون، هم
+
+406
+00:37:00,120 --> 00:37:00,240
+بارزون، هم بارزون، هم بارزون، هم بارزون، هم
+
+407
+00:37:00,240 --> 00:37:09,900
+بارزون، هم بارزون، هم بارزون، هم بعليهم بنيانة ..
+
+408
+00:37:09,900 --> 00:37:16,700
+طيب هم بارزون .. من يقرأها؟ أحسنتي هم بارزون
+
+409
+00:37:16,700 --> 00:37:22,040
+أنهينا الحكم الثاني ننتقل إلى الحكم الثالث من
+
+410
+00:37:22,040 --> 00:37:26,000
+أحكام ال ميم الساكنة ونختم به هذا اللقاء اللي هي
+
+411
+00:37:26,000 --> 00:37:31,120
+الإظهار الشفوي كما قلنا أن للميم الساكنة ثلاث أحكام
+
+412
+00:37:31,120 --> 00:37:38,800
+إضغام شفوي مع الميم، إخفاء شفوي مع الباء، إظهار شفوي
+
+413
+00:37:38,800 --> 00:37:42,940
+مع باقي حروف اللغة العربية وقلنا الإظهار لغة
+
+414
+00:37:42,940 --> 00:37:47,400
+البيان والوضوح وفي الاصطلاح إخراج الحرف المظهر من
+
+415
+00:37:47,400 --> 00:37:53,090
+مخرجه بغير غنّة وهنا تخرج الميم الساكنة من مخرجها
+
+416
+00:37:53,090 --> 00:37:58,990
+بغير غنّة إذا جاء وراها أي حرف من حروف الإظهار
+
+417
+00:37:58,990 --> 00:38:03,330
+الشّفوي، وهي كل حروف اللغة العربية ما عدا حرف الميم
+
+418
+00:38:03,330 --> 00:38:08,890
+والباء وهنا يعني يجب الحذر من إخفاء الميم مع حرف
+
+419
+00:38:08,890 --> 00:38:14,670
+الواو والفاء لأن الواو والفاء والميم والباء كلهم
+
+420
+00:38:14,670 --> 00:38:19,550
+مخرجهم من نفس المخرج وهو الشفتين فلأن مخرج الواو
+
+421
+00:38:19,550 --> 00:38:24,510
+ومخرج الفاء من الشفتين عند ضم شفتي حرف الواو أو 
+
+422
+00:38:24,510 --> 00:38:27,750
+عند وضع أطراف الثنايا العليا على بطن الشفة السفلى
+
+423
+00:38:28,210 --> 00:38:33,710
+بيخرج منه حرف الفاء فلابد من التحقيق وإظهار ال
+
+424
+00:38:33,710 --> 00:38:40,050
+ميم والحذر من أن يوجد إخفاء عندما يأتي حرف ال
+
+425
+00:38:40,050 --> 00:38:43,810
+ميم ساكنة ووراها حرف الواو أو الفاء طبعا سبب 
+
+426
+00:38:43,810 --> 00:38:48,550
+الإظهار يا أخوات ما بين الميم وبقية الحروف كلها
+
+427
+00:38:48,550 --> 00:38:54,700
+التباعد ما بين الميم وكل الحروف الموجودة عندنا
+
+428
+00:38:54,700 --> 00:39:02,260
+أمثلة أيكم أحسنوا عملًا.. كيف نقرأها يا أخوات؟ أيكم
+
+429
+00:39:02,260 --> 00:39:07,100
+أحسنوا عملًا.. طيب وبما كنتم تدرسون.. من تقرأها؟
+
+430
+00:39:07,100 --> 00:39:10,900
+تفضلي أختي و
+
+431
+00:39:10,900 --> 00:39:16,600
+بما كنتم تدرسون.. كنتم تدرسون.. الميم بتظهر لأن
+
+432
+00:39:16,600 --> 00:39:23,090
+جاء وراها حرف التاء.. أمثلكم أمثلكم الميم وراها حرف
+
+433
+00:39:23,090 --> 00:39:32,230
+الثّاء لهم جنات لهم جنات الميم نحققها لأنها مخرجها 
+
+434
+00:39:32,230 --> 00:39:37,830
+عندما تبقى الشفتان وراها حرف الجيم وحرف الجيم من 
+
+435
+00:39:37,830 --> 00:39:43,330
+حروف الإظهار الشفوي طب في أموالهم حق تظل
+
+436
+00:39:44,710 --> 00:39:50,130
+في أموالهم حق معلوم أولئك هم خير الباريّة كيف
+
+437
+00:39:50,130 --> 00:39:57,190
+نقرأها؟ أولئك هم خيرًا.. أولئك هم خيرًا الباريّة..
+
+438
+00:39:57,190 --> 00:40:02,050
+الميم وراها حرف الخاء.. كذلك أي كلام هنا وهم
+
+439
+00:40:02,050 --> 00:40:08,330
+ظالمون مثلًا ينصركم عليهم فإنكم غالبون بمعنى إنه
+
+440
+00:40:08,330 --> 00:40:12,790
+إذا جاءت حرف الميم وجاء بعدها أي حرف من حروف اللغة
+
+441
+00:40:12,790 --> 00:40:20,010
+العربية ما عدا الميم والبا من سميهم إيه أظهر شافهم
+
+442
+00:40:20,680 --> 00:40:23,400
+نكتفي بهذا القدر وبارك الله فيكم جميعًا وجزاكم الله 
+
+443
+00:40:23,400 --> 00:40:25,860
+خيرًا والسلام عليكم ورحمة الله وبركاته
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/MoT2lQglIWU_raw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/MoT2lQglIWU_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..0afc62744fed4f243a17dd897d7c5672bdaa069c
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/MoT2lQglIWU_raw.srt
@@ -0,0 +1,1908 @@
+1
+00:00:11,400 --> 00:00:14,240
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:14,240 --> 00:00:18,880
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+3
+00:00:18,880 --> 00:00:23,900
+آله وصحبه وسلم موضوع درسنا اليوم حكم ال ميم والنون
+
+4
+00:00:23,900 --> 00:00:28,170
+المشددتينلكن قبل أن ندخل في هذا الموضوع نريد أن
+
+5
+00:00:28,170 --> 00:00:32,190
+نتعرف على الحرف المشدد ما هو الحرف المشدد يا
+
+6
+00:00:32,190 --> 00:00:41,670
+أخوات؟ هناك حرف مشدد سواء كان مثلا اب و أشد تبت
+
+7
+00:00:41,670 --> 00:00:49,570
+ذأبي لهبي و تب هذا حرف مشدد أو مثلا فلما أن هذا
+
+8
+00:00:49,570 --> 00:00:53,090
+الحرف المشدد من أي شيء مكون فضل أخت
+
+9
+00:01:00,260 --> 00:01:04,560
+إذا يا أخوات الحرف المشدد أصلا هو مكوّن من حرفين
+
+10
+00:01:04,560 --> 00:01:08,720
+مضغمات مع بعضهم البعض الحرف الأول ساكن والحرف
+
+11
+00:01:08,720 --> 00:01:12,400
+الثاني متحرك اضغم الحرف الأول في الحرف الثاني
+
+12
+00:01:12,400 --> 00:01:18,580
+فصاروا كأنهم حرفا واحدا مشددة لذلك يسمى حرف مشدد
+
+13
+00:01:18,580 --> 00:01:31,640
+مثل الحج تبت يد أبي لهبي وتبالحق الجنة الطامة
+
+14
+00:01:31,640 --> 00:01:37,420
+هذه كلها الميم والجنة الجنة النون مشددة تبت ده أبي
+
+15
+00:01:37,420 --> 00:01:43,700
+لهبه وتب البه مشددة الحق القاف أيضا مشددة وهكذا
+
+16
+00:01:43,700 --> 00:01:49,180
+إذا الحرف المشدد هو أصلا مكون من حرفين متجاورين
+
+17
+00:01:49,180 --> 00:01:54,960
+الأول ساكن والثاني متحرك وهم متماثلان أصلاأضغبوا
+
+18
+00:01:54,960 --> 00:01:59,780
+مع بعضهم البعض فصاروا حرفا واحدا مشددة والحرف
+
+19
+00:01:59,780 --> 00:02:05,820
+المشدد ينقسم إلى قسمين حرف مشدد بغنى وحرف مشدد
+
+20
+00:02:05,820 --> 00:02:09,800
+بغير غنى الحرف المشدد اللي بغنى ماهو يا أخوات؟
+
+21
+00:02:13,190 --> 00:02:18,470
+أصلا الغنى صفة ملازمة للميم والنون المشددتين إذا
+
+22
+00:02:18,470 --> 00:02:23,790
+اللي فيه غنى يكون يا إما ميم يا إما نون مثلا إن
+
+23
+00:02:23,790 --> 00:02:33,390
+الله فلمّا كذلك الميم عما يتسألون الميم والنون
+
+24
+00:02:33,390 --> 00:02:40,050
+المشددتين غنى بمقدار حركتينأما الحرف المشدد اللي
+
+25
+00:02:40,050 --> 00:02:44,510
+بدون غنة أي حرف من حروف اللغة العربية مثلا مثال
+
+26
+00:02:44,510 --> 00:02:52,510
+ذلك اياك اياك نعبد و اياك نستعين حرف اليا في اياك
+
+27
+00:02:52,510 --> 00:02:57,630
+هذا حرف مشدد هو أصلا في الأساس عبارة عن حرفين حرف
+
+28
+00:02:57,630 --> 00:03:02,250
+ساكن و حرف متحرك اضغموا مع بعضهم البعض و هم أيضا
+
+29
+00:03:02,250 --> 00:03:11,320
+متمثلين كذلك التوابونالتوابون حرف ت مشدد مع
+
+30
+00:03:11,320 --> 00:03:19,060
+الإضغام، الضالين و هكذا أما بالنسبة يا أخوات لحكم
+
+31
+00:03:19,060 --> 00:03:25,230
+ال ميم والنون المشددتينله حكم خاص وهو عنوان الدرس
+
+32
+00:03:25,230 --> 00:03:30,330
+اللي نتكلم نحن عنه الآن حكم الميم والنون المشددتين
+
+33
+00:03:30,330 --> 00:03:35,970
+طبيعي جدا تحقيق الغنى فيهما بمقدار حركتين إذا
+
+34
+00:03:35,970 --> 00:03:42,970
+عندما نجد أن هناك ميم أو نون مشددة فعلينا أن نحقق
+
+35
+00:03:42,970 --> 00:03:48,830
+الغنى التي في النون أو الميم المشددتين مثال ذلك يم
+
+36
+00:03:48,830 --> 00:03:53,690
+النون كيف نقراه يا أخوات؟ من يقرأ؟يمنون عليك أن
+
+37
+00:03:53,690 --> 00:04:01,510
+أسلموا يمنون عليك أن أسلموا يمنون
+
+38
+00:04:01,510 --> 00:04:08,170
+عليك أن أسلموا يمنون عليك أن أسلموا يمنون عليك أن
+
+39
+00:04:08,170 --> 00:04:09,870
+أسلموا يمنون عليك أن أسلموا يمنون عليك أن أسلموا
+
+40
+00:04:09,870 --> 00:04:10,030
+يمنون عليك أن أسلموا يمنون عليك أن أسلموا يمنون
+
+41
+00:04:10,030 --> 00:04:10,030
+عليك أن أسلموا يمنون عليك أن أسلموا يمنون عليك أن
+
+42
+00:04:10,030 --> 00:04:10,030
+أسلموا يمنون عليك أن أسلموا يمنون عليك أن أسلموا
+
+43
+00:04:10,030 --> 00:04:10,030
+يمنون عليك أن أسلموا يمنون عليك أن أسلموا يمنون
+
+44
+00:04:10,030 --> 00:04:10,030
+عليك أن أسلموا يمنون عليك أن أسلموا يمنون عليك أن
+
+45
+00:04:10,030 --> 00:04:10,110
+أسلموا يمنون عليك أن أسلموا يمنون عليك أن أسلموا
+
+46
+00:04:10,110 --> 00:04:12,790
+يمنون عليك أن أسلموا
+
+47
+00:04:15,950 --> 00:04:21,750
+فإذا جاءت الطامة
+
+48
+00:04:21,750 --> 00:04:27,970
+الكبرى طبعا في عنا الطام مشددة الطامة وكذلك الميم
+
+49
+00:04:27,970 --> 00:04:31,530
+مشددة الموضوع اللي معناه اللي هو الميم المشددة
+
+50
+00:04:31,530 --> 00:04:35,710
+حكمها غن بمقدار حركتين الآية الثالثة أمني أقراها
+
+51
+00:04:35,710 --> 00:04:37,650
+يا أخوات فضلي
+
+52
+00:04:39,590 --> 00:04:47,070
+تقرأ جزاك الله خير عما يتساءلون عما نحقق الغنى
+
+53
+00:04:47,070 --> 00:04:52,830
+الموجودة في الميم و لكن قد تقع الغنى يا أخوات في
+
+54
+00:04:52,830 --> 00:04:57,520
+نهاية الكلمةإذا وقعت الغنّة في نهاية الكلمة أيضًا
+
+55
+00:04:57,520 --> 00:05:04,980
+لابد أن نحققها لو وقفنا عليها مثال ذلك كلمة جان
+
+56
+00:05:04,980 --> 00:05:13,600
+نحقق الغنّة لم يطمثهن إنس قبلهم ولا جان
+
+57
+00:05:14,900 --> 00:05:22,860
+أه ولا جان نحقق الغنّة الموجودة في الجان كذلك هُن
+
+58
+00:05:22,860 --> 00:05:29,860
+لباس لكم و أنتم لباس لهم نحقق الغنّة لأننا وقفنا
+
+59
+00:05:29,860 --> 00:05:35,940
+على النون المشددة طيب لو قلنا يا أخوات من يعرف لنا
+
+60
+00:05:35,940 --> 00:05:40,980
+الغنّة؟ نحن نقول غنّة من يعرف الغنّة؟ فضل أخت
+
+61
+00:05:46,940 --> 00:05:53,420
+ولو تنوينا يعني صوته أغن وركب فيه جسمي حرفي ال ميم
+
+62
+00:05:53,420 --> 00:05:57,800
+والنون ولو تنوينا يعني أحكام لإن الميم والنون
+
+63
+00:05:57,800 --> 00:06:01,120
+والتنوين
+
+64
+00:06:01,120 --> 00:06:05,100
+النون والتنوين أصلا التنوين عبارة عن النونلذلك صوت
+
+65
+00:06:05,100 --> 00:06:10,400
+أغان مركب في جسمي ال ميم والنون و لو تنوينا مقداره
+
+66
+00:06:10,400 --> 00:06:15,920
+حركتين يخرج من الخيشوم لا عمل لللسان به إذا صوت
+
+67
+00:06:15,920 --> 00:06:19,980
+أغان مركب في جسمي ال ميم والنون يخرج من الخيشوم
+
+68
+00:06:19,980 --> 00:06:26,320
+مقداره حركتين ما معنى الخيشوم؟اللي هو أعلى الألف،
+
+69
+00:06:26,320 --> 00:06:29,500
+يعني ممكن الواحد .. طبعا لا عمل لللسان به .. ممكن
+
+70
+00:06:29,500 --> 00:06:36,320
+الواحد يغلق فمه، يقول .. هذا الصوت اسمه غنة، فلمّا
+
+71
+00:06:36,320 --> 00:06:42,520
+إنّه، هذا كله غنةالغنى تعني في الغنى هو صوت أغن
+
+72
+00:06:42,520 --> 00:06:47,720
+مُركّب في جسمي الميم والنون مقدار حركتين يخرج من
+
+73
+00:06:47,720 --> 00:06:53,080
+الخيشوم وهو صفة ملازمة لحرفي الميم والنون وكذلك
+
+74
+00:06:53,080 --> 00:06:58,560
+تتحقق في الميم والنون المشددتين لذلك في عنا يا
+
+75
+00:06:58,560 --> 00:07:04,040
+أخوات للغنى عدة مراتبالمرتبة الأولى من مراتب الغنى
+
+76
+00:07:04,040 --> 00:07:09,140
+أعلى مرتبة هي الـ ميم والنون المشددتين يعني عندما
+
+77
+00:07:09,140 --> 00:07:14,740
+نرى ميم ونون مشددة يجب علينا أن نحقق الغنى وتظهر
+
+78
+00:07:14,740 --> 00:07:20,240
+الغنى في الميم والنون المشددتين سواء كان واصلا أو
+
+79
+00:07:20,240 --> 00:07:30,850
+وقفا لو وصلناهاعما يتساءلوها وصلنا عما يتساءلون
+
+80
+00:07:30,850 --> 00:07:36,770
+هذا تحقق القنعة ولو وقفنا عليها لم يطمثهن إنس
+
+81
+00:07:36,770 --> 00:07:43,610
+قبلهم ولا جاءنحقق الغنّة الموجودة في النون
+
+82
+00:07:43,610 --> 00:07:48,710
+المشاددة كذلك بالنسبة للميم والنون المشاددة تانية
+
+83
+00:07:48,710 --> 00:07:53,670
+قد تكون مشاددة وقد تكون مضغمة يعني ال ميم مع الميم
+
+84
+00:07:53,670 --> 00:08:00,880
+أو النون مع النون مع بعضهما يصبح عندنا غنّةالمرتب
+
+85
+00:08:00,880 --> 00:08:05,360
+الأولى وهي أعلى مراتب الغنى عندما تكون المي والنون
+
+86
+00:08:05,360 --> 00:08:11,020
+مشد ذتين فيجب إظهار الغنى وتحقيق الغنى كذلك إذا
+
+87
+00:08:11,020 --> 00:08:15,940
+كانوا مضغمات مع بعضهم البعض نشوف مثلا هنا في قول
+
+88
+00:08:15,940 --> 00:08:20,320
+تعالى وَلَهُم مَن يَشْتَهُونَ مَن يقرأها؟
+
+89
+00:08:26,080 --> 00:08:33,100
+أحسنتي أنا حققت الغنى كذلك
+
+90
+00:08:33,100 --> 00:08:42,020
+وما بيكم من نعمة من يقرأها؟ فضليه وما بيكم من
+
+91
+00:08:42,020 --> 00:08:48,740
+نعمة كم غنى هنا يا أخوات فيه؟الميم مع الميم والنون
+
+92
+00:08:48,740 --> 00:08:54,360
+مع النون كلا هما تحقق فيها الإضغام يعني أضغم أو
+
+93
+00:08:54,360 --> 00:08:58,880
+أدخل الحرف الأول في الحرف الثاني فصاروا كأنهم حرفا
+
+94
+00:08:58,880 --> 00:09:04,880
+واحدا مشددة كذلك من مالي وابنين من يقرأها؟
+
+95
+00:09:09,520 --> 00:09:15,480
+ممالي وبنين ممال هي عبارة عن اضغام النون مع الميم
+
+96
+00:09:15,480 --> 00:09:20,600
+اضغام بغنى فتحققت الغنى هذه هي المرتبة الأولى أما
+
+97
+00:09:20,600 --> 00:09:24,960
+يا أخوات بالنسبة للمرتبة الثانية فهي الغنى الناتجة
+
+98
+00:09:24,960 --> 00:09:31,520
+عن اضغام النون الساكنة بحرفي الواو واليا مثال ذلك
+
+99
+00:09:31,520 --> 00:09:38,920
+فميعمل من الصالحات فميعمل ايش في هذهفيها غنة لكن
+
+100
+00:09:38,920 --> 00:09:45,920
+نجد أن الغنة المتحققة من قوله فما يعمل أو ما يعمل
+
+101
+00:09:45,920 --> 00:09:52,660
+ميواقع ووالدي وما ولد ليست بقوة الغنة الأولى أو
+
+102
+00:09:52,660 --> 00:09:55,760
+المرتبة الأولى المتحققة في ال meme و النون
+
+103
+00:09:55,760 --> 00:10:04,590
+المشددتين أليس كذلك؟ فما يعمل أو ووالدي وما ولدما
+
+104
+00:10:04,590 --> 00:10:09,990
+يعمل هذا كلها عبارة عن غنّة وهي في المرتبة الثانية
+
+105
+00:10:09,990 --> 00:10:14,110
+المرتبة الثالثة يا أخوات هي الغنّة الناتجة عن
+
+106
+00:10:14,110 --> 00:10:17,910
+إخفاء النون الساكنة بحروف الإخفاء تخفى النون
+
+107
+00:10:17,910 --> 00:10:22,590
+الساكن أو التنوين بحروف الإخفاء من يعني يذكر لنا
+
+108
+00:10:22,590 --> 00:10:26,450
+حروف الإخفاء التي تخفى عندها النون الساكنة أو
+
+109
+00:10:26,450 --> 00:10:28,970
+التنوين اه تفضلي
+
+110
+00:10:35,140 --> 00:10:41,220
+أحسنتي طبعا صف ذاثنى حرف الصاد و الذال أول حرف من
+
+111
+00:10:41,220 --> 00:10:46,860
+كل كلمة صف ذاثنى كم جاذ شخص قد سمى دم طيبا زدفى
+
+112
+00:10:46,860 --> 00:10:52,940
+تقن ضعظالمه كم كلمة خمسناشر كلمة بخمسناشر حرف أول
+
+113
+00:10:52,940 --> 00:10:58,920
+حرف من كل كلمة مثلا حرف الصاد مين صلصالحرف الصين
+
+114
+00:10:58,920 --> 00:11:06,080
+الانسان حرف الذال من ذالذي اما نجد ان هناك فيها
+
+115
+00:11:06,080 --> 00:11:11,260
+غنى ولكن غنى هي في المرتبة الثالثة عندنا امثلة
+
+116
+00:11:11,260 --> 00:11:18,400
+الانسان من صالصال ايش فيها الانسان فيها اخفاء نون
+
+117
+00:11:18,400 --> 00:11:23,780
+ساكنة وراها حرف الصين من صالصال نون ساكنة وراها
+
+118
+00:11:23,780 --> 00:11:30,910
+حرف الصاد من ذالذينون ساكنة ورا حرف الذال و هكذا
+
+119
+00:11:30,910 --> 00:11:34,550
+في باقي حروف الإخفاء المكون من الخمسة و أشرة حرفا
+
+120
+00:11:34,550 --> 00:11:38,970
+هذه هي المرتبة الثالثة عندنا يا أخوات مرتبة رابعة
+
+121
+00:11:38,970 --> 00:11:44,050
+وهي غنط الميم والنون في حالة الإظهار أو عندما تكون
+
+122
+00:11:44,050 --> 00:11:48,770
+متحركتين يعني عندما تكون النون مظهرة متى تظهر
+
+123
+00:11:48,770 --> 00:11:56,990
+النون الساكن أو التنوين؟ فضليأو التحميل و أحب أن
+
+124
+00:11:56,990 --> 00:12:04,280
+أقعد في البيتأحسنتِ إذا جاء أي حرف من كلمة أخي أول
+
+125
+00:12:04,280 --> 00:12:09,400
+حرف من كل كلمة أخي ها كعلما حازها وغيره خسري يعني
+
+126
+00:12:09,400 --> 00:12:13,500
+ستة كلمات بستة حروف اللي هي الهمزة و الها و العين
+
+127
+00:12:13,500 --> 00:12:16,740
+و الحا و الغين و الخا إذا جاء أي حرف من هذه الحروف
+
+128
+00:12:16,740 --> 00:12:20,840
+بعد النون الساكن أو التنوين بنحكم على النون الساكن
+
+129
+00:12:20,840 --> 00:12:26,020
+أو التنوين بالاضهار فبتكون هذه هي المرتبة الرابعة
+
+130
+00:12:26,020 --> 00:12:32,230
+عندما نقول منهممنه كلمة منه نون ساكنة وراها حرف
+
+131
+00:12:32,230 --> 00:12:37,990
+الها في عندنا إظهار حلقي ينأونا ينأونا هذا إظهار
+
+132
+00:12:37,990 --> 00:12:40,670
+إذا النون الساكنة اللي وراها أي حرف من حروف
+
+133
+00:12:40,670 --> 00:12:45,000
+الإظهار بيكون عندنا أي مرتبة يا أخواتيالمرتبة
+
+134
+00:12:45,000 --> 00:12:53,020
+الرابعة كذلك لو كان مثلا الحرف متحرك نعم مثلا نقى
+
+135
+00:12:53,020 --> 00:12:57,460
+مال حرف الميم في كلمة مال الميم المتحركة والنون
+
+136
+00:12:57,460 --> 00:13:01,380
+المتحركة أيضا تعد من المرتبة الرابعة يعني وبعض
+
+137
+00:13:01,380 --> 00:13:05,940
+العلماء جعلها الميم المتحركة هي من المرتبة الخامسة
+
+138
+00:13:05,940 --> 00:13:11,570
+طيب بالنسبة يا أخوات لمقدار الغنىيعني من حيث أصل
+
+139
+00:13:11,570 --> 00:13:15,070
+الغنّة أو غير أصل الغنّة في عنا يا بنات مقدار
+
+140
+00:13:15,070 --> 00:13:19,230
+الغنّة في عنا أصل الغنّة وهي ثابتة في الميم والنون
+
+141
+00:13:19,230 --> 00:13:25,390
+عندما تخرج من مخرجها نقول مثلا ينأونةفيها أصل
+
+142
+00:13:25,390 --> 00:13:30,250
+الغنى النون اللي هي المظهرة أصل الغنى يتتحقق بمجرد
+
+143
+00:13:30,250 --> 00:13:36,590
+أن يخرج حرف ال ميم أو النون مثلا مال مال M الميم
+
+144
+00:13:36,590 --> 00:13:42,970
+ساكنة أو الميم المتحركة فيها أصل الغنى لكن مرتبة
+
+145
+00:13:42,970 --> 00:13:48,150
+الكمال في الغنى عندما تكون الميم والنون مشددتين
+
+146
+00:13:48,150 --> 00:13:53,210
+فيسمى هذه مرتبة الكمالإذا يا أخوات بالنسبة لمراتب
+
+147
+00:13:53,210 --> 00:13:57,410
+الغنى عندنا مرتباتين المرتبة الأولى وهي مرتبة أصل
+
+148
+00:13:57,410 --> 00:14:02,490
+الغنى وتتحقق في الحرف الـ ميم والنون عندما يخرج
+
+149
+00:14:02,490 --> 00:14:09,950
+يعني المتحرك والساكن فيه أصل الغنى مثل ين أونامال
+
+150
+00:14:09,950 --> 00:14:14,490
+حرف ال meme المتحرك نعم حرف النون المتحرك و هكذا
+
+151
+00:14:14,490 --> 00:14:19,010
+طيب و في عندنا مرتبة الكمال اللي في الغنى متى يعني
+
+152
+00:14:19,010 --> 00:14:23,790
+بتكون أعلى مرتبة من مرتبة الغنى اللي هي عندما تكون
+
+153
+00:14:23,790 --> 00:14:28,350
+ال meme و النون المشددتين تتحقق فيها الغنى لمقدار
+
+154
+00:14:28,350 --> 00:14:34,220
+حركتين طيب ماهو مقدار الغنى يا أخوات؟حركتان ممكن
+
+155
+00:14:34,220 --> 00:14:39,120
+تلغونا حركتان ما معنى الحركة؟ الحركة بمعنى قبض
+
+156
+00:14:39,120 --> 00:14:46,840
+الأصبع أو بصته بشكل معتدل ليس بشكل بطيء جدا ولا
+
+157
+00:14:46,840 --> 00:14:51,840
+بشكل سريع جدا إنما هو بمقدار أن يقول الإنسان يعني
+
+158
+00:14:51,840 --> 00:14:57,000
+الحركتين تعدلوا ثانية كما قال العلماءوالحركتين
+
+159
+00:14:57,000 --> 00:15:02,340
+تعادلوا أن يقول إنسان رقم مكون من رقمين يعني واحد
+
+160
+00:15:02,340 --> 00:15:07,420
+وعشرين اتنين وعشرين تلاتة وعشرين اربعة وعشرين يعني
+
+161
+00:15:07,420 --> 00:15:11,320
+بمقدار قبض الأصبع أو بصله بتعادل الحركتين الحركة
+
+162
+00:15:11,320 --> 00:15:14,660
+الواحدة قبض الأصبع والحركة الثانية بص الأصبع
+
+163
+00:15:14,660 --> 00:15:19,480
+الحركتين بمقدار قبض الأصبع أو بصله او قبض الأصبع و
+
+164
+00:15:19,480 --> 00:15:25,810
+بصله بمقدار زمن يعني وحدة زمنيةيقدرها الإنسان في
+
+165
+00:15:25,810 --> 00:15:30,190
+ذهنه وتسمى هذه مراتب من المراتب الغنى نكتفي بهذا
+
+166
+00:15:30,190 --> 00:15:34,570
+القدر بالنسبة للغنى وناخد الموضوع اللذي يليه بإذن
+
+167
+00:15:34,570 --> 00:15:38,010
+الله سبحانه وتعالى والموضوع اللذي سوف ناخده هو
+
+168
+00:15:38,010 --> 00:15:45,830
+موضوع أحكام اللامات اللامات يا أخوات طبعا اللام
+
+169
+00:15:45,830 --> 00:15:52,960
+الساكنة عندنا كم حكم لللام الساكنة؟اللام الساكنة
+
+170
+00:15:52,960 --> 00:15:57,780
+اللام اللي عليها سفون أيضا لها خمسة أحكام الحكم
+
+171
+00:15:57,780 --> 00:16:04,220
+الأول هو لام اللتعريف لام الفعل لام الأمر لام
+
+172
+00:16:04,220 --> 00:16:11,120
+الإسم لام الحرف وكل لام من هذه اللامات السواكن له
+
+173
+00:16:11,120 --> 00:16:16,350
+أحكامه الخاصةإن أول حكم من أحكام اللامات السواكن
+
+174
+00:16:16,350 --> 00:16:22,050
+هو اللام المتحققة في قلة تعريف لام قلة تعريف هي
+
+175
+00:16:22,050 --> 00:16:27,230
+لام ساكنة زائدة عن بنية الكلمة مسوقة بهمزة وصل
+
+176
+00:16:27,230 --> 00:16:32,470
+مفتوحة عند اتداء بها وبعدها اسم يعني أي اسم من
+
+177
+00:16:32,470 --> 00:16:39,900
+الأسماء لو سبقناه بقلة تعريف نقول مثلا شمسالشمس
+
+178
+00:16:39,900 --> 00:16:48,880
+طمر القمر مدرسة المدرسة حج الحج فلام التعريف هي
+
+179
+00:16:48,880 --> 00:16:53,540
+لام أصلية و لا زائدة زائدة لأنه ممكن أن نستغن عنها
+
+180
+00:16:53,540 --> 00:16:57,720
+يعني مدرسة نستغن عنها إذا أردنا أن نعرفها نقول
+
+181
+00:16:57,720 --> 00:17:03,380
+المدرسة إذا لام التعريف هي لام ساكنة زائدة عن بنية
+
+182
+00:17:03,380 --> 00:17:10,030
+الكلمة مسوقة بهمزة وصل مفتوحةالمدرسة مسبوقة بهمزة
+
+183
+00:17:10,030 --> 00:17:14,730
+واصل مفتوحة عند الابداء بها وبعدها اسم سواء كان صح
+
+184
+00:17:14,730 --> 00:17:20,590
+التخلص منها يعني ممكن تتجرد مثل مدرسة المدرسة أو
+
+185
+00:17:20,590 --> 00:17:26,710
+مثلا لم يصح تجريدها من ال التعريف مثل طوله الذي و
+
+186
+00:17:26,710 --> 00:17:32,410
+التي الذي التي هي التعريف لكنها لا يمكن أن تتجرد
+
+187
+00:17:32,410 --> 00:17:38,500
+من ذي يعني لا نقول ذي و تي إنما الذيالتي، إذا
+
+188
+00:17:38,500 --> 00:17:43,760
+تعريف لام التعريف هي لام ساكنة زاد عن بنية الكلمة
+
+189
+00:17:43,760 --> 00:17:48,140
+مسبوقة بهمزة وصل مفتوحة عند الإبتداء بها وبعدها
+
+190
+00:17:48,140 --> 00:17:55,180
+اسم سواء صح تجريدها نحو الشمس القمر أم لم يصح لعدم
+
+191
+00:17:55,180 --> 00:17:59,420
+استقامة الكلمة بدونها يعني لا يمكن أن نستغني عنها
+
+192
+00:17:59,420 --> 00:18:05,140
+مثل قوله الذي هو التيأما بالنسبة يا أخوات حكم
+
+193
+00:18:05,140 --> 00:18:12,590
+اللام التعريف أو حالات اللام التعريف لها حالتانإما
+
+194
+00:18:12,590 --> 00:18:18,230
+الإظهار وإما الإضغام إما أن نظهرها فنقول القمر
+
+195
+00:18:18,230 --> 00:18:23,870
+وإما أن نضغمها فنقول الشمس القمر هين أظهرناها
+
+196
+00:18:23,870 --> 00:18:30,410
+القمر وإما أما التانية الشمس لم نقول الشمس لأنها
+
+197
+00:18:30,410 --> 00:18:35,770
+بتكون ثقيلة على اللسان فنقول الشمس ومن هنا حالات
+
+198
+00:18:35,770 --> 00:18:43,120
+اللام التعليف الإظهاروالاضغام الاضهار تظهر لام
+
+199
+00:18:43,120 --> 00:18:49,060
+التعليف إذا جاء بعدها أي حرف من حروف ابغى حجك وخاف
+
+200
+00:18:49,060 --> 00:18:54,740
+عقيمه ما معنى ابغى حجك وخاف عقيمه؟ يعني اطلب الحج
+
+201
+00:18:54,740 --> 00:18:58,640
+وخاف أن يذهب الحج هبقى هل الجملة هي المعنية؟ يعني
+
+202
+00:18:58,640 --> 00:19:03,660
+المعنى هو المطلوب؟المطلوب فقط هو أن نجمع الحروف
+
+203
+00:19:03,660 --> 00:19:08,300
+الإظهار في كلمة يكون لها معنى مفهوم والعلماء طبعا
+
+204
+00:19:08,300 --> 00:19:14,220
+السابقون ذكروا هذه الجملة حتى يسهل علينا معرفة
+
+205
+00:19:14,220 --> 00:19:19,600
+حروف الإظهار مثلا ابغى حجك وخفع قيمه حرف الهمزة و
+
+206
+00:19:19,600 --> 00:19:23,460
+البا و الغين و الحا و الجين و الكاف و الواو و الخا
+
+207
+00:19:23,460 --> 00:19:27,620
+و الفا و باخر الأحرف إذا كام حرف هذه الحروف أخوات؟
+
+208
+00:19:28,910 --> 00:19:33,370
+أربعة عشر حرفا مجموعة في قوله ابغى حجك وخف عقيمه
+
+209
+00:19:33,370 --> 00:19:37,270
+وهي نصف حروف اللغة العربية يعني حروف اللغة العربية
+
+210
+00:19:37,270 --> 00:19:43,850
+28 حرف نصفها 14 حرف مجموعة في قوله ابغى حجك وخف
+
+211
+00:19:43,850 --> 00:19:49,870
+عقيمه بيكون عندنا اظهار حكم الله فالتعريف تظهر
+
+212
+00:19:49,870 --> 00:19:57,760
+فنقول مثلا عندنا الأرض أو غيرهاحكم لام التعريف في
+
+213
+00:19:57,760 --> 00:20:04,540
+إبغى حجك أو خفعة قيمه الإظهار و يسمى هذا الحكم أو
+
+214
+00:20:04,540 --> 00:20:08,580
+اللام هنا تسمى قمرية لماذا سميناها قمرية يا أخوات؟
+
+215
+00:20:09,500 --> 00:20:15,160
+لأن الـ Lam تظهر بعد أي حرف من حروف ابغى حجك وخفع
+
+216
+00:20:15,160 --> 00:20:21,080
+قيمه، وسبب اظهار هو التباعد ما بين حرف ال ال مع
+
+217
+00:20:21,080 --> 00:20:25,320
+هذه الحروف الاربعد عشر و مع ال Lam طبعا بتكون
+
+218
+00:20:25,320 --> 00:20:30,320
+متماثلةيعني سبب الإظهار هو التباعد بين مخرج اللام
+
+219
+00:20:30,320 --> 00:20:36,260
+وهذه الحروف الاربعت عشر اللي هي ابغى حجك وخف عقيمه
+
+220
+00:20:36,260 --> 00:20:43,970
+انشوف أمثلة على الإظهارمثلًا حرف الهمزة همزة
+
+221
+00:20:43,970 --> 00:20:49,590
+مينقلت بكلمة فيها مبدوء أو اسم مبدوء بهمزة ونريد
+
+222
+00:20:49,590 --> 00:20:56,210
+أن ندخل عليه للتعريف مثلًا أنعام الأنعام حرف
+
+223
+00:20:56,210 --> 00:21:02,410
+الباباصير البصير بنفع نقول البصير يعني مابنفع نضغم
+
+224
+00:21:02,410 --> 00:21:05,850
+اللام في هذه الحروف لأنها بتكون ثقيلة على اللسان
+
+225
+00:21:07,010 --> 00:21:10,310
+إذا هذه الحروف أصلا الأحكام كلها أحكام التجويض
+
+226
+00:21:10,310 --> 00:21:18,810
+كلها حتى يتسهل علينا النطق فنقول بصير البصير أنعام
+
+227
+00:21:18,810 --> 00:21:24,410
+الأنعم هي أظهرنا الأل أظهرنا الأل غير عن مثلا
+
+228
+00:21:24,410 --> 00:21:32,820
+الشمس لنقول الشمس ماذا نقول الشمسطيبات الطيبات ولا
+
+229
+00:21:32,820 --> 00:21:37,020
+نقول الطيبات لأنها بتكون ثقيلة على اللسان طب غاشية
+
+230
+00:21:37,020 --> 00:21:47,720
+الغاشية حج الحج الجبل الجبل الجبل كبير الكبير
+
+231
+00:21:48,380 --> 00:21:55,020
+وَدُود الوَدُود الالتعريف هل هي أصلية ولا زائدة؟
+
+232
+00:21:55,020 --> 00:21:59,640
+زائدة عن بنية الكلمة لم لم زادة عن بنية الكلمة
+
+233
+00:21:59,640 --> 00:22:06,240
+مسبوقة بهمزة واصل مفتوحة لذلك لا نقول الجبلالكبير
+
+234
+00:22:06,240 --> 00:22:13,380
+نقول الكبير همزة وصل مفتوحة بتلحق أول الأسماء ممكن
+
+235
+00:22:13,380 --> 00:22:19,780
+تكون صالحة لتجريدها مثل جبل الجبل أو لا يصلح أن
+
+236
+00:22:19,780 --> 00:22:24,040
+تتجرد الإسم من ال التعريف مثل الذي و التي و هذه
+
+237
+00:22:24,040 --> 00:22:29,820
+الحكم الأول أو الحالة الأولى من حالات اللام
+
+238
+00:22:29,820 --> 00:22:34,530
+التعريف اللي هو الإظهارالحالة الثانية يا أخوات هو
+
+239
+00:22:34,530 --> 00:22:42,190
+الإضغام تضغم لام التعريف بأي حرف من حروف هذا البيت
+
+240
+00:22:42,190 --> 00:22:49,090
+طب ثم صل رحم تفوذ ضف ذانعم دعسو أظن زر شريفا
+
+241
+00:22:49,090 --> 00:22:53,690
+للكرام أول حرف من كل كلمة هذا البيت طبعا وضعه
+
+242
+00:22:53,690 --> 00:23:00,880
+العلماء في 14 حرف او 14 كلمة ب14 حرف طب حرف الططب
+
+243
+00:23:00,880 --> 00:23:06,440
+ثم صل حرف الثا وحرف الصاد، رحمن حرف الرا، تفس حرف
+
+244
+00:23:06,440 --> 00:23:12,500
+التا، ضف ذا نعم، دعسو أظن زر شريفا للكرام، هذه
+
+245
+00:23:12,500 --> 00:23:17,180
+الحروف أربعتاشر حرف، أي حرف من هذه الحروف جاء بعد
+
+246
+00:23:17,180 --> 00:23:25,100
+اللام، لابد أن يدغم اللام فيها، وتسمىاللام في هذه
+
+247
+00:23:25,100 --> 00:23:29,660
+الحالة اللام مضغمة أو لام شمسية لماذا تسميها
+
+248
+00:23:29,660 --> 00:23:35,540
+شمسية؟ لعدم ظهورها عند النطق و لأنها يعني تشبه
+
+249
+00:23:35,540 --> 00:23:40,700
+اللام لو دخلت على الشمس يعني كلمة شمس إذا أدخلنا
+
+250
+00:23:40,700 --> 00:23:45,380
+اللام عليها بيصير الشمس وإذا كان في عيننا بالنسبة
+
+251
+00:23:45,380 --> 00:23:50,620
+للقمرية أو المظهرة القمر لو دخلت اللام عليهابتصير
+
+252
+00:23:50,620 --> 00:23:56,600
+القمر فلمّا كانت اللام تظهر عند لفظة القمر و تضغم
+
+253
+00:23:56,600 --> 00:24:02,580
+عند لفظة الشمس سمينا اللام المظهرة قمرية و اللام
+
+254
+00:24:02,580 --> 00:24:08,080
+المضغمة شمسية نسبة إلى القمر و نسبة إلى الشمس
+
+255
+00:24:08,080 --> 00:24:13,140
+فضلوا بالنسبة لللام مثلا اللام بحسها مش مضغمة
+
+256
+00:24:16,920 --> 00:24:21,680
+أه بالنسبة لللام بيصير تماثل ما بين اللام الأولى و
+
+257
+00:24:21,680 --> 00:24:26,240
+اللام الثانية لكن اللام الأولى بتضغم كلها مثلا ليه
+
+258
+00:24:26,240 --> 00:24:34,010
+خلينا نقول lamb فاللام مثلا ليمون الليمونأحنا
+
+259
+00:24:34,010 --> 00:24:39,190
+دخلنا للتعريف على كلمة ليمون فاضغمت اللام الأولى
+
+260
+00:24:39,190 --> 00:24:43,510
+في اللام الثانية فبتبين كأنهما لاما واحدة مشددة
+
+261
+00:24:43,510 --> 00:24:48,470
+فنقول الليمون اللام الأولى كلها دابت اضغمت في أي
+
+262
+00:24:48,470 --> 00:24:52,840
+حرففي اللام الثانية فاللي نرفضه احنا هي اللام
+
+263
+00:24:52,840 --> 00:24:57,680
+الثانية المضغمة فنقول الليمون لكنها اللام مضغمة
+
+264
+00:24:57,680 --> 00:25:01,600
+يعني اللام اللي التعريف مضغمة مع كلمة ليمون
+
+265
+00:25:01,600 --> 00:25:04,880
+والامثلة على ذلك سوف تاتي ان شاء الله يعني اللام
+
+266
+00:25:04,880 --> 00:25:09,100
+مع اللام تماثل واللام مع باقي حروف اللغة الباقي
+
+267
+00:25:09,100 --> 00:25:13,980
+حروف الطبث المصير الرحمن بتكون ايش تقارب نشوف
+
+268
+00:25:13,980 --> 00:25:21,650
+الأمثلة على ذلك حرف الطالطارق هل يصلح أن نقول
+
+269
+00:25:21,650 --> 00:25:26,670
+الطارق يعني نجد أنها ثقيلة على اللسان أن نقول
+
+270
+00:25:26,670 --> 00:25:34,350
+الطارق مباشرة والسماء والطارق الطارق مش الطارق
+
+271
+00:25:34,350 --> 00:25:45,540
+ثوابالثواب صابرون الصابرون الرحمن الرحمن التواب
+
+272
+00:25:45,540 --> 00:25:49,880
+التواب اللام اللي هنا في هذه الكلمات كلها اللام
+
+273
+00:25:49,880 --> 00:25:55,800
+إيش يا أخوات اسمها؟ اللام الشمسية أو اللام المضغمة
+
+274
+00:25:55,800 --> 00:26:00,700
+في عندنا لفظ الجلالة مثلا اللي فيها اضغم اللام مع
+
+275
+00:26:00,700 --> 00:26:07,410
+اللام أصلا بالنسبة للفظ الجلالة نحن نقول اللهولكن
+
+276
+00:26:07,410 --> 00:26:13,190
+أصل كلمة الله اللى هو لفظ الجلالة هو أصلا إله دخلت
+
+277
+00:26:13,190 --> 00:26:18,830
+عليه ال التعريف فصارت الإله ثم حُدفت الهمزة يعني
+
+278
+00:26:18,830 --> 00:26:25,490
+ده كلمة إلهدخلت عليه ال التعريف فصارت الإله برضه
+
+279
+00:26:25,490 --> 00:26:31,390
+كلمة الإله فيها نوع من الثقل حُدفت همزة الإلهة
+
+280
+00:26:31,390 --> 00:26:36,110
+الالهة حُدفت الهمزة هنا من باب التخفيف فصارت الله
+
+281
+00:26:36,110 --> 00:26:42,260
+لكن اللام مع اللام يعني ال التعريف مع لهاللام مع
+
+282
+00:26:42,260 --> 00:27:03,700
+اللام أضغمت اللام مع اللام فصارت الله اللام
+
+283
+00:27:03,700 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+284
+00:27:06,480 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+285
+00:27:06,480 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+286
+00:27:06,480 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+287
+00:27:06,480 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+288
+00:27:06,480 --> 00:27:06,480
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+289
+00:27:06,480 --> 00:27:06,500
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+290
+00:27:06,500 --> 00:27:06,700
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+291
+00:27:06,700 --> 00:27:06,700
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+292
+00:27:06,700 --> 00:27:06,700
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+293
+00:27:06,700 --> 00:27:06,700
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+294
+00:27:06,700 --> 00:27:06,700
+اللام اللام اللام اللام اللام اللام اللام اللام
+
+295
+00:27:06,700 --> 00:27:08,030
+اللام اللام اللام اللام اللامطيب لو سألنا الأخوات
+
+296
+00:27:08,030 --> 00:27:14,570
+ما الفرق بين الإله و الله لفظ الجلالة؟ في فرق
+
+297
+00:27:14,570 --> 00:27:18,870
+بينهم أيه أخوات؟
+
+298
+00:27:18,870 --> 00:27:24,490
+أحسنت
+
+299
+00:27:24,490 --> 00:27:24,930
+ممتاز
+
+300
+00:27:29,190 --> 00:27:33,890
+ممتازة، إذا لفظ الجلالة الله لا يُطلق إلا على لفظ
+
+301
+00:27:33,890 --> 00:27:40,910
+الجلالة الله الإله اللي بحق لكن إله أو الإله يُطلق
+
+302
+00:27:40,910 --> 00:27:44,250
+على الإله بحق وعلى الإله بباطل يعني الكفار بيقول
+
+303
+00:27:44,250 --> 00:27:50,450
+الإله إلهي عن من؟ عن الصلم ولذلك هي يعبدون الآلهة
+
+304
+00:27:50,450 --> 00:27:54,470
+ما هي الآلهة عند الكفار؟ الأصنام والأبقار من هذه
+
+305
+00:27:54,470 --> 00:28:00,200
+المعبدات التي يعبدونها يُطلق عليها إلهلكننا لا
+
+306
+00:28:00,200 --> 00:28:05,280
+نطلق على البقرة أو على الصنم لفظ الجلالة الله الله
+
+307
+00:28:05,280 --> 00:28:08,800
+لا يطلق إلا على لفظ الجلالة الله لا إله إلا الله
+
+308
+00:28:08,800 --> 00:28:12,160
+سبحانه وتعالى أما الإله ممكن أن يطلق على الإله
+
+309
+00:28:12,160 --> 00:28:16,800
+بحقي والإله بباطي يعني أنا ممكن كمؤمن أقول إلهي
+
+310
+00:28:18,290 --> 00:28:22,290
+مولاي، اله يغفر الله و هم يغفروننا مثلا نرفض الله
+
+311
+00:28:22,290 --> 00:28:27,290
+أو إلهية جزء إله بحق ولذلك لفظ الجلال يا أخوات
+
+312
+00:28:27,290 --> 00:28:33,750
+أحيانا نجد أنه يظهر يعني يفخم و أحيانا يرقق متى
+
+313
+00:28:33,750 --> 00:28:38,430
+يفخم و متى يرقق يعني أحيانا نقول الله و أحيانا
+
+314
+00:28:38,430 --> 00:28:46,050
+نقول الله متى نقول الله فضل أختكأحسنتِ لو كان
+
+315
+00:28:46,050 --> 00:28:52,210
+مفتوح مقابله أو مقابله مضموم مثل إن الله ما بنفع
+
+316
+00:28:52,210 --> 00:29:00,950
+نقول إن الله ثقيلة إن الله وملائكته كذلك رسول الله
+
+317
+00:29:00,950 --> 00:29:07,950
+فخّمناها لكن متى ترقق لو كانت مسلوقة بكسر بسم الله
+
+318
+00:29:09,040 --> 00:29:11,420
+أو من نتيجة التخلص من التقاء الساكنين
+
+319
+00:29:39,030 --> 00:29:42,530
+هذا يا أخوات بالنسبة للـ Lam الساكنة في قلة
+
+320
+00:29:42,530 --> 00:29:46,390
+التعريف وحنا قولنا إن اللامات السواكن كام حكم يا
+
+321
+00:29:46,390 --> 00:29:50,950
+أخوات؟ خمسة أحكام الحكم الثاني اللي هو Lam الفعل
+
+322
+00:29:50,950 --> 00:29:55,550
+يعني سواء كان فعل ماضي ولا مضارع ولا أمر أحيانا
+
+323
+00:29:55,550 --> 00:30:00,530
+بيقع بالفعل الماضي ولا المضارع ولا الأمر Lam ساكنة
+
+324
+00:30:00,530 --> 00:30:04,870
+مثلا هي Lam ساكنة أصلية في الكلمة وليست زائدةأحنا
+
+325
+00:30:04,870 --> 00:30:07,990
+قلنا أن التعريف اللام اللي فيها إيش يا أخوات زائد
+
+326
+00:30:07,990 --> 00:30:12,230
+عن منية الكلمة زي مدرسة المدرسة ثانية لكن بالنسبة
+
+327
+00:30:12,230 --> 00:30:18,270
+للام الفعل فهي لام أصلية في الفعل نفسه تكون في وسط
+
+328
+00:30:18,270 --> 00:30:25,340
+الكلمة أو في آخر الكلمة مثال ذلك الهاكمالهاكم فعل
+
+329
+00:30:25,340 --> 00:30:31,820
+ماضي الهاكم التكاثر فالتقى فعل ماضي فالتقى اللام
+
+330
+00:30:31,820 --> 00:30:38,880
+ساكنة وحكم هي أخوات الإظهار فالتقى أنزلنا أنزلنا
+
+331
+00:30:38,880 --> 00:30:45,720
+اللام ساكنة أرسلنا أرسلنا اللام برضه ساكنة هذا لما
+
+332
+00:30:45,720 --> 00:30:50,720
+يكون الفعل ماضي أو ممكن أن يكون كذلك الفعل مضارع
+
+333
+00:30:50,720 --> 00:30:57,710
+مثل يلتقطهميلطقطه اللام ساكنة لا نقول يلو طقطه لا
+
+334
+00:30:57,710 --> 00:31:04,530
+نقول يلطقطه اللام ساكنة كذلك ألم أقل ألم أقل نجد
+
+335
+00:31:04,530 --> 00:31:12,330
+أن اللام هنا رقعت في نهاية الكلمة و يلطقطه رقعت في
+
+336
+00:31:12,330 --> 00:31:17,650
+منتصف الكلمة هل ممكن للام الساكنة أن تقع في أول
+
+337
+00:31:17,650 --> 00:31:25,310
+الكلمة؟ ممكن، ليش لأ؟لأن العرب لا يبدأون الكلام
+
+338
+00:31:25,310 --> 00:31:31,470
+بساكن ولا يقفون على متحرك فلا نقول كلمة مبدوعة
+
+339
+00:31:31,470 --> 00:31:35,790
+بساكن وحتى إذا أردنا أن نبدأ بساكن لابد أن نحركها
+
+340
+00:31:35,790 --> 00:31:40,390
+سواء كان نضعت قبل همزة واصل أو مثلا هي نفسها تتحرك
+
+341
+00:31:40,390 --> 00:31:44,730
+بالكسرة حتى نستطيع الإبتداء بها لكن اللام في الفعل
+
+342
+00:31:44,730 --> 00:31:49,700
+تقع في منتصف الكلمة أو في آخر كلمة لام ساكنةسواء
+
+343
+00:31:49,700 --> 00:31:54,900
+كان فعل ماضي مثل الهاكم أو فعل مضارع مثل يلتقطه في
+
+344
+00:31:54,900 --> 00:31:59,820
+وصف الكلمة أو في آخر كلمة مثل ألم أقول لكم ومن
+
+345
+00:31:59,820 --> 00:32:05,580
+يتوكل على الله أيضا اللام ساكنة وممكن أن يقع كذلك
+
+346
+00:32:05,580 --> 00:32:10,360
+اللام الساكنة في الفعل الأمر مثل قول تعالى قل
+
+347
+00:32:10,360 --> 00:32:17,730
+تعالوا قل تعالوا اللام ساكنة و بعدهاحرف ت بتكون
+
+348
+00:32:17,730 --> 00:32:25,890
+اللام ساكنة كذلك فاجعل أفئذة اللام أيضا ساكنة قل
+
+349
+00:32:25,890 --> 00:32:32,630
+نعم و هكذا إذا اللام الفعل ممكن يكون ساكن في الفعل
+
+350
+00:32:32,630 --> 00:32:38,310
+الماضي في الفعل المضارع في الفعل الأمر وحكمه حكم
+
+351
+00:32:38,310 --> 00:32:46,140
+اللام الفعل هو الإظهارإلا إذا وقع بعد اللام لام أو
+
+352
+00:32:46,140 --> 00:32:52,710
+را إذا ما هو حكم لام الفعل يا أخوات؟الإظهار مطلقًا
+
+353
+00:32:52,710 --> 00:32:58,450
+إلا إذا جاء بعدها حرف Lam أو حرف Ra فالـ Lam مع
+
+354
+00:32:58,450 --> 00:33:03,290
+الـ Lam تماثل و الـ Lam مع الـ Ra تقارب مثال ذلك
+
+355
+00:33:03,290 --> 00:33:08,110
+في قوله تعالى قُلْ لَكُم مِيعَادُ يَوْمٍ قُلْ
+
+356
+00:33:08,110 --> 00:33:14,400
+لَكُم لا نقرأها قُلْ لَكُمبالتضغم اللام الأولى في
+
+357
+00:33:14,400 --> 00:33:18,780
+اللام الثانية فيصيراني من حيث اللفظ لاما واحدة
+
+358
+00:33:18,780 --> 00:33:25,360
+مشددة نقول قلكم ميعاد طبعا اضغموا و بدون غنى لأن
+
+359
+00:33:25,360 --> 00:33:30,580
+حرف اللام ليست من حروف الغنى كذلك و يجعل لكم و
+
+360
+00:33:30,580 --> 00:33:35,910
+يمددكم بأموالي و بنينا و يجعل لكمو يجعل لكم اللام
+
+361
+00:33:35,910 --> 00:33:40,710
+الأولى أضغمت في اللام الثانية هذا يعني من باب
+
+362
+00:33:40,710 --> 00:33:44,570
+التماثل يعني سبب الإضغام فيه يجعل لكم اشي أخوات
+
+363
+00:33:46,110 --> 00:33:50,690
+التماثل ما بين الـ Lam و الـ Ram كذلك التقارب ما
+
+364
+00:33:50,690 --> 00:33:54,490
+بين الـ Lam و الـ Ram في قوله و قول ربي زدني علمه
+
+365
+00:33:54,490 --> 00:33:59,190
+أو قول ربي أعلمه أو و قول ربي ارحمهما كما ربياني
+
+366
+00:33:59,190 --> 00:34:05,390
+صغيرة الـ Lam مع الـ Ram اتغام تقارب الـ Lam مع
+
+367
+00:34:05,390 --> 00:34:10,470
+الـ Lam اتغام تماثل هذا يا أخوات بالنسبة لحكم الـ
+
+368
+00:34:10,470 --> 00:34:15,420
+Lam الفعلثالثاً لام الأمر لام الأمر هذه اللام
+
+369
+00:34:15,420 --> 00:34:22,640
+الزائدة يعني لام الفعل وتعده لام أصلية كذلك لام
+
+370
+00:34:22,640 --> 00:34:27,360
+الإسم أصلية لكن لام الأمر تعده زائدة زي لام
+
+371
+00:34:27,360 --> 00:34:33,400
+التعريف هنا لام الأمر مثلا هي لام ساكنة زائدة عن
+
+372
+00:34:33,400 --> 00:34:37,800
+بنية الكلمة تدخل على الفعل المضارعولكن يجب أن
+
+373
+00:34:37,800 --> 00:34:43,720
+يسبقها أحد الحروف الثلاثة الواو أو الفا أو ثمة
+
+374
+00:34:43,720 --> 00:34:50,840
+مثلا في قول تعالى ثم ليقضوا تفثهم وليوفوا نذورهم
+
+375
+00:34:50,840 --> 00:34:56,940
+وليطوفوا بالبيت العتيقى ثم ليقضوا إلا في قوله
+
+376
+00:34:56,940 --> 00:35:03,780
+ليقضوا ثم ليقضوااللام ساكنة، يبقى هي أصلا هي
+
+377
+00:35:03,780 --> 00:35:07,800
+يقضوا، دخلت عليها اللام الأمر، إذا دخلت عليها
+
+378
+00:35:07,800 --> 00:35:11,540
+اللام على الفعل المضارع بتجعله أمر، ولكن لابد أن
+
+379
+00:35:11,540 --> 00:35:16,860
+يسبق بحرف إيه؟ حرف ثمة، حرف عطفي وفيد التراخي، ثم
+
+380
+00:35:16,860 --> 00:35:27,090
+يقضوا تفثهمواليوفوا نظورهم وليطوفوا
+
+381
+00:35:27,090 --> 00:35:31,830
+بالبيت العتيق كذلك قوله تعالى فليمدد بسبب إلى
+
+382
+00:35:31,830 --> 00:35:40,050
+السماء ثم ليقطع فلينظر فليمدد فليمدد اللامالها
+
+383
+00:35:41,350 --> 00:35:47,530
+ساكنة لكن مسبوقة بحرف الفا طيب ثم اليقطع ثم اليقطع
+
+384
+00:35:47,530 --> 00:35:52,190
+اللي لام ساكنة ها ثم اليقطع اللي لام ساكنة لكن يجب
+
+385
+00:35:52,190 --> 00:35:57,810
+أن تسبق بحرف ثم او بحرف اي حرف ثم او الواو او الفا
+
+386
+00:35:57,810 --> 00:36:05,890
+طيب فلينظرفعل مضارع ينظر دخلت عليه لام الأمر ولكن
+
+387
+00:36:05,890 --> 00:36:09,970
+لابد عشان ساكنة والعرب لا يبدأون الكلام بساكن لابد
+
+388
+00:36:09,970 --> 00:36:14,010
+أن تكون مسبوقة بأي حرف من الحروف الثلاثة يعني ينفع
+
+389
+00:36:14,010 --> 00:36:19,390
+نقول فلينظر ثم لينظر ولينظر مثلا في غير القرآن لكن
+
+390
+00:36:19,390 --> 00:36:26,250
+هنا فليمدد بسبب إلى السماء ثم ليقطع فلينظر هل يذهب
+
+391
+00:36:26,250 --> 00:36:30,710
+أن كيدهما يغيظيعني هذه الكلمات اللي هي لابد أن
+
+392
+00:36:30,710 --> 00:36:35,910
+تكون مصفوقة بالف أو بثم أو بال .. بال .. بال wow
+
+393
+00:36:37,090 --> 00:36:41,510
+حكم لام الأمر يا أخوات اللي هي الإظهار مطلقا ولكن
+
+394
+00:36:41,510 --> 00:36:46,610
+عندنا يجب الحذر أو أن يحذر القارئ من إضغام اللام
+
+395
+00:36:46,610 --> 00:36:51,910
+في حرف ال T لأنهم بتكون ال ال و ال it مخرجها قريب
+
+396
+00:36:51,910 --> 00:36:56,470
+يعني ممكن واحد كلمة فالتقم طائفة منهم معاك ممكن
+
+397
+00:36:56,470 --> 00:37:04,210
+يقول فاتقم ممكن يضغمها لأن ال ال و ال itممكن يقول
+
+398
+00:37:04,210 --> 00:37:10,470
+فالتقم يضغط لكن يجب أن يحضر فلا يقول فالتقم فليقول
+
+399
+00:37:10,470 --> 00:37:18,650
+فالتقم فالتقم طائفة منهم معك وليأخذوا أسلحتهمكويس؟
+
+400
+00:37:18,650 --> 00:37:25,170
+فلتقم يبقى حكمها الإظهار حكم اللام في الفعل الأمر
+
+401
+00:37:25,170 --> 00:37:31,030
+الإظهار ويجب أن نظهرها ولكن يجب أن نحذر من أن تضغم
+
+402
+00:37:31,030 --> 00:37:34,310
+اللام مع التالة لأنها قريبة عليها في المخرج فلتقم
+
+403
+00:37:34,310 --> 00:37:38,270
+طائفة منهم معك وليأخذوا أسلحتهم فإذا سجدوا
+
+404
+00:37:38,270 --> 00:37:43,130
+فليكونوا من وراكم ولا تأتي طائفة أخرى لم يصلوا
+
+405
+00:37:43,340 --> 00:37:47,780
+فليصلوا معك وليأخذوا حذراهم وأسلحتهم كل هذا عبارة
+
+406
+00:37:47,780 --> 00:37:55,040
+عن فعل مضارع مسبوق باللهام فجعلته أمر عندنا يا
+
+407
+00:37:55,040 --> 00:38:00,260
+أخوات فائدةإذا ابتدأ بالام الأمر يعني لا نبدأها
+
+408
+00:38:00,260 --> 00:38:03,920
+مثلا في غير القرآن طبعا أو للاختبار أو للتعليم
+
+409
+00:38:03,920 --> 00:38:10,280
+كلمة ثم ليقضوا إذا عرضنا أن نقرأها بدون ثم يعني
+
+410
+00:38:10,280 --> 00:38:15,160
+نجف عن كلمة ثم من باب الاختبار هي الأصل أن نقول ثم
+
+411
+00:38:15,160 --> 00:38:19,700
+ليقضوا تفثهملكن من بعد الاختبار ممكن المدرس يقول
+
+412
+00:38:19,700 --> 00:38:25,020
+للطالب مثلا طف عند كلمة ثم وابدأ الكلام بقوله
+
+413
+00:38:25,020 --> 00:38:29,840
+لياخده كيف تقراها هل تقراها بالسكون ولا بالكسرة؟
+
+414
+00:38:30,350 --> 00:38:34,290
+بالكسر لابد أن تقرأ بالكسر لأن العرب لا يبدأون
+
+415
+00:38:34,290 --> 00:38:41,610
+الكلام بحرف ساكن فنقول ليقضوا تفذهم وليوفوا نذورهم
+
+416
+00:38:41,610 --> 00:38:45,490
+يبقى النقطة الأولى أو الفادة الأولى إذا تبدأ بلام
+
+417
+00:38:45,490 --> 00:38:50,310
+الأمر من باب الاختبار أو التعليم لا نبدأها بالساكن
+
+418
+00:38:50,310 --> 00:38:54,730
+بل نبدأها بالكسر يكسر الساكن أو تكسر لام الأمر
+
+419
+00:38:54,730 --> 00:39:00,040
+فنقول ليقضوا تفذهمهذه النقطة الأولى النقطة الثانية
+
+420
+00:39:00,040 --> 00:39:03,920
+يا أخوات لا يجوز الابداء بالام الأمر إذا كانت
+
+421
+00:39:03,920 --> 00:39:08,980
+مسبوقة بواو أو فا يعني لأن الفا في الكلمة ملزقة
+
+422
+00:39:08,980 --> 00:39:12,360
+يعني كأننا بدنا نبدأ من نص الكلمة لا يجوز يعني ما
+
+423
+00:39:12,360 --> 00:39:16,160
+بنفع نقول فليمدد بسبب الإذا السماء نقول ف نجف عن
+
+424
+00:39:16,160 --> 00:39:21,800
+كلمة ف و بقول ليمددأما كلمة ثم لأنها كلمة مستقلة
+
+425
+00:39:21,800 --> 00:39:26,500
+ثم نجف عندها ليقدوا بس من باب التعليم واللي هي في
+
+426
+00:39:26,500 --> 00:39:31,820
+الأساس ثم ليقدوا تفتهم لكن حتى بالنسبة فاليمدد أو
+
+427
+00:39:31,820 --> 00:39:39,510
+كلمةواليوفوا نذورهم مثلا مع الواو و الفا لا نقف
+
+428
+00:39:39,510 --> 00:39:43,410
+عند الكلمة لا نقف عند الواو ولا نقف عند الفا لشدة
+
+429
+00:39:43,410 --> 00:39:47,170
+تعلقها بالحرف اللي ينيه يعني ما بنفع نقف عند كلمة
+
+430
+00:39:47,170 --> 00:39:54,290
+ف بعدين نقول ليمدد بل تقرأ فليمدد كذلك هنا ثم
+
+431
+00:39:54,290 --> 00:39:59,550
+اليقضوا تفثهم وليوفوا نذورهم ما بنفع نقول مثلا ثم
+
+432
+00:39:59,550 --> 00:40:05,930
+اليقضوا تفثهم وو نبدأ ليوفوا نذورهم .. بل يقول و
+
+433
+00:40:05,930 --> 00:40:11,590
+ليوفوا نذورهم و ليطوفوا بالبيت العتيقهذه هي الحكم
+
+434
+00:40:11,590 --> 00:40:15,970
+التالت الحكم الرابع الحكم الرابع حتى ننهي الموضوع
+
+435
+00:40:15,970 --> 00:40:19,450
+الحكم الرابع اللي هو لام الإسم لام الإسم سهل جدا
+
+436
+00:40:19,450 --> 00:40:22,990
+يا أخوات هي لام أصلية في الكلمة تكون متواجدة في
+
+437
+00:40:22,990 --> 00:40:28,090
+وسط الكلمة ولا تكون إلا متوسطة نحو واختلافوا
+
+438
+00:40:28,090 --> 00:40:33,370
+ألسنتكم و ألوانكم اللام في ألسنتكم و ألوانكم اسمها
+
+439
+00:40:33,370 --> 00:40:37,110
+لام إيش يا أخوات؟لام الإسم هو أصلية حكمها الإظهار
+
+440
+00:40:37,110 --> 00:40:42,110
+مطلقا إن عبادي ليس لك عليهم سلطان اللام في سلطان
+
+441
+00:40:42,110 --> 00:40:47,010
+أيضا أصلية حكمها الإظهار إذا حكم لام الإسم الإظهار
+
+442
+00:40:47,010 --> 00:40:51,710
+بقى علينا حكم لام الحرف اللام الحرفية هي اللام
+
+443
+00:40:51,710 --> 00:40:56,810
+الساكنة الموجودة في الحرف ولم تقع في القرآن إلا في
+
+444
+00:40:56,810 --> 00:41:01,110
+حرفين اللام تقع في القرآن إلا في حرفين اللي هي هل
+
+445
+00:41:01,110 --> 00:41:08,040
+وبلإذا ما هي الحروف التي فيها لام الحرف؟ بس هل و
+
+446
+00:41:08,040 --> 00:41:14,600
+بل مثلا قوله تعالى بل هم في شك يلعبون بل هم إيش
+
+447
+00:41:14,600 --> 00:41:17,920
+حكم اللام إذا وقع وراها أي حرف من حرف اللغة
+
+448
+00:41:17,920 --> 00:41:23,170
+العربية؟الإظهار إلا إذا وقع عليك فيها وراها اللام
+
+449
+00:41:23,170 --> 00:41:27,450
+أو الرا لأن اللام مع اللام تماثل و اللام مع الرا
+
+450
+00:41:27,450 --> 00:41:32,130
+تقارب هنا يا أخوات بل هم في شك يلعبون إيش الحكم
+
+451
+00:41:32,130 --> 00:41:37,930
+إظهار بل رفعه الله ليه إيش فيها إضغام إضغام متقارب
+
+452
+00:41:37,930 --> 00:41:42,530
+ما بين اللام و الرا نقول بل رفعه الله ليه بل رفعه
+
+453
+00:41:42,530 --> 00:41:48,430
+اللام تضغم مع الرا طيب قل هل تلبصون بناهل تربصونا؟
+
+454
+00:41:48,430 --> 00:41:54,370
+قول هل .. كيف نقرأها؟ قول هل .. فيها إظهار .. قول
+
+455
+00:41:54,370 --> 00:42:01,690
+هل .. في قوله .. فقول هل لك إلاء تزكى؟ أيضا إظهار
+
+456
+00:42:01,690 --> 00:42:07,250
+إذا متى تض يضغم الحرف لام الحرف بالذي يليه؟ إذا
+
+457
+00:42:07,250 --> 00:42:12,310
+كان وراه إيش؟ حرف اللاماللام مع اللام فيها تماثل
+
+458
+00:42:12,310 --> 00:42:17,890
+واللام مع الراء تقارب مثال ذلك فقول هل لك إلى أن
+
+459
+00:42:17,890 --> 00:42:24,810
+تزكى فقول هل لك أصلا هل هي لام الحرف ولك لام
+
+460
+00:42:24,810 --> 00:42:27,330
+الكلمة اللي وراها تضغم اللام الأولى في اللام
+
+461
+00:42:27,330 --> 00:42:34,310
+الثانية فنقرأها فقول هل لك إلى أن تزكى أو قوله بل
+
+462
+00:42:34,310 --> 00:42:41,260
+لما يذوقوا عذاب بل لما كيف بنقرأها؟بل لما هو كذلك
+
+463
+00:42:41,260 --> 00:42:44,700
+مع الرا احنا قلنا اللام مع اللام اللام الحرف مع
+
+464
+00:42:44,700 --> 00:42:51,360
+اللام تماثل اللام الحرف مع الرا تقارب مثل قوله بل
+
+465
+00:42:51,360 --> 00:42:55,230
+رفعه الله ليه كيف نقرأها يا أخوات؟باررفعه الله
+
+466
+00:42:55,230 --> 00:42:59,070
+عليه باررفعه اللام تضغم تضغم اللام الأولى في الرا
+
+467
+00:42:59,070 --> 00:43:03,730
+بحيث يصيران را واحدة مشددة باررفعه الله عليه كل
+
+468
+00:43:03,730 --> 00:43:08,450
+اللام تضغم بحرف الرا ويستثنى من ذلك حالة واحدة في
+
+469
+00:43:08,450 --> 00:43:12,910
+كل القرآن وهي في قوله كَلَّا بَلْ رَانَ عَلَى
+
+470
+00:43:12,910 --> 00:43:16,890
+قُلُوبِهِم مَا كَانُوا يَكْسِبُونَ كَلَّا بَلْ
+
+471
+00:43:16,890 --> 00:43:21,430
+رَانَةَ فيها عندنا سكتة لطيفة عند الإمام حفظوهي
+
+472
+00:43:21,430 --> 00:43:27,710
+سكتة واجبة نسكت و عندها حتى نفرق ما بين بل و رانا
+
+473
+00:43:27,710 --> 00:43:32,090
+لأن هذا كلمتين بل لحال و رانا لحال لأن لو وصل ..
+
+474
+00:43:32,090 --> 00:43:37,310
+لو وصلناها هتصير بران و معنى بران .. إيش يا أخوات؟
+
+475
+00:43:37,310 --> 00:43:42,690
+عبارة عن مثنى برة بهذا نكون قد أنهينا أحكام إلامات
+
+476
+00:43:42,690 --> 00:43:45,870
+السواكل وإن شاء الله نأخذ موضوع آخر في الدرس
+
+477
+00:43:45,870 --> 00:43:47,850
+القادم برك الله فيكم والسلام عليكم
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/bGzmOGH00Y0_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/bGzmOGH00Y0_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..51f4e3aaf3d28fc6edc8c0ca78f156d0d4d19d97
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/bGzmOGH00Y0_postprocess.srt
@@ -0,0 +1,2092 @@
+1
+00:00:12,800 --> 00:00:15,640
+أعوذ بالله السلام عليك من الشيطان الرجيم بسم الله
+
+2
+00:00:15,640 --> 00:00:19,200
+الرحمن الرحيم الصلاة والسلام على أشرف المرسلين ما
+
+3
+00:00:19,200 --> 00:00:23,340
+بعد يلا نبدأ يا بنات يلا اقرأيا بس
+
+4
+00:00:26,370 --> 00:00:33,340
+أهو من الله السميع العليم من الشيطان الراجيمبسم
+
+5
+00:00:33,340 --> 00:00:40,040
+الله الرحمن الرحيم حميم
+
+6
+00:00:40,040 --> 00:00:49,260
+تنزل الكتاب من الله العزيزي الحكيم إن في السماوات
+
+7
+00:00:49,260 --> 00:00:57,820
+والأرض لآيات للمؤمنين وفي خلقكم وما يبث من
+
+8
+00:01:01,400 --> 00:01:13,500
+أيات .. أيات لقوم يوقنون واختلاف الليل والنهار وما
+
+9
+00:01:13,500 --> 00:01:26,320
+أنزل الله وما أنزل الله من السماء من رزقهمن رزق
+
+10
+00:01:26,320 --> 00:01:34,740
+فأحيا به الأرض بعد موتها وتصريف الرياح وتصريف
+
+11
+00:01:34,740 --> 00:01:44,760
+الرياح آيات لقوم يعقلون تلك آيات الله نتلوها عليك
+
+12
+00:01:44,760 --> 00:01:56,460
+بالحق فبأي حديث بعد الله وآياته يؤمنونويل لكل أفاك
+
+13
+00:01:56,460 --> 00:02:08,700
+أثيم يسمع آية الله تتلى عليه ثم يصر مستكبرا ثم يصر
+
+14
+00:02:08,700 --> 00:02:19,120
+مستكبرا كأن لم يسمعها فبشره بعذاب أليموإذا علم من
+
+15
+00:02:19,120 --> 00:02:30,600
+آياتنا شيئا اتخذها هزوا أولئك لهم عذاب مهين من
+
+16
+00:02:30,600 --> 00:02:40,860
+ورائهم جهنم ولا يغني عنهم ولا يغني عنهم ما كسبوا
+
+17
+00:02:40,860 --> 00:02:50,790
+شيئا ولا ما اتخذواولما اتخذوا من دون الله أولياء
+
+18
+00:02:50,790 --> 00:03:01,990
+ولهم عذاب عظيم هذا هدا .. هذا هدا والذين كفروا
+
+19
+00:03:01,990 --> 00:03:09,290
+بآيات ربهم لهم عذاب من رجس أليم الله يفتح عليك
+
+20
+00:03:15,210 --> 00:03:20,290
+اقرايا هادئة يالا
+
+21
+00:03:20,290 --> 00:03:29,470
+اعوذ بالله من الشيطان الرجيم بسم الله وعظمه رباطيه
+
+22
+00:03:29,470 --> 00:03:35,590
+أبوه والذي سخر لكم البحر وانشجرهم ملكه فيه بأمره
+
+23
+00:03:35,590 --> 00:03:39,730
+لأ ماتمديش حرف المادة زيها ده حركتين فيه هي بأمره
+
+24
+00:03:41,400 --> 00:03:47,440
+الله الذي سخّ لكم البحر لتجري الحق فيه الأبرز
+
+25
+00:03:47,440 --> 00:03:54,600
+ويتبذروا من حبه و لعنكم تشكرهم و سخّ لكم ما في
+
+26
+00:03:54,600 --> 00:04:01,820
+السماوات و ما في الأرض جميعا منه إن في ذلك الآية
+
+27
+00:04:01,820 --> 00:04:09,710
+اللي قاملآيات لقوم يتفكرون تنوي المعلم اتغام بدون
+
+28
+00:04:09,710 --> 00:04:16,130
+غنى، تجافيش عنده لآيات
+
+29
+00:04:16,130 --> 00:04:21,250
+لقوم لآيات لقوم يتفكرون
+
+30
+00:04:30,610 --> 00:04:37,950
+بآيات لقوم يتفكرون أحسنت، نعم كل الذين آمنوا
+
+31
+00:04:37,950 --> 00:04:44,870
+يغفروا للذين لا يردون أي رضا ليجزي قوما بما كانوا
+
+32
+00:04:44,870 --> 00:04:52,230
+يفسدون قوما بما كانوا كل الذين آمنوا يغفروا للذين
+
+33
+00:04:52,230 --> 00:05:00,380
+لا يردون أي رضا ليجزي قوما بما كانوا يفسدونمن
+
+34
+00:05:00,380 --> 00:05:08,840
+عاملة .. من عاملة اظهار .. من عاملة اظهار .. من
+
+35
+00:05:08,840 --> 00:05:17,160
+عاملة اظهارها فلنفس ال .. ومن أساء .. لأ نفس الاشي
+
+36
+00:05:17,160 --> 00:05:26,320
+اظهر ومن أساءومنها سأب عليها ثم إلى ربكم ترجعون
+
+37
+00:05:26,320 --> 00:05:34,140
+ولقد آتينا بني إسرائيل الكتاب والقرن والنبوة
+
+38
+00:05:34,140 --> 00:05:43,660
+ورزقناهم من الطيبات وفضلناهم على العالمين وآتيناهم
+
+39
+00:05:43,660 --> 00:05:53,450
+بينات من الأمرفمقتله إلا من بعد ما .. إلا من بعد
+
+40
+00:05:53,450 --> 00:06:03,350
+ما جاءه العلم بغيا بينهم إن ربك
+
+41
+00:06:03,350 --> 00:06:10,750
+يقضي بينهم يوم القيامة يقضي بينهم يوم القيامة فيما
+
+42
+00:06:10,750 --> 00:06:18,930
+كان فيهمسجد بيه كانوا ال wow حركتين كانوا فيه في
+
+43
+00:06:18,930 --> 00:06:24,030
+ما كانوا فيه اختلفوا لأ هي كان زيها ده الحركتين في
+
+44
+00:06:24,030 --> 00:06:33,510
+ما كانوا فيه في ما كانوا فيه اختلفوا ثم جعلناك على
+
+45
+00:06:33,510 --> 00:06:39,790
+شريعة النمي الأمري فاتتبعها ولا تتبع أمك اوصلي
+
+46
+00:06:39,790 --> 00:06:42,270
+فاتتبعها ولا تتبع أمك
+
+47
+00:07:01,200 --> 00:07:09,820
+إنهم ليه غنوه في
+
+48
+00:07:09,820 --> 00:07:19,490
+إضغام ليه غنوهإنهم ليه قُلوا عنك من الله شيئا، وإن
+
+49
+00:07:19,490 --> 00:07:26,230
+الظالمين بعضهم أولياء
+
+50
+00:07:26,230 --> 00:07:34,310
+بعض، وإن الظالمين بعضهم أولياء بعض، والله وليهم
+
+51
+00:07:34,310 --> 00:07:35,510
+المستقيم
+
+52
+00:07:39,840 --> 00:07:49,080
+وهده ورحمه وهده ورحمته لقوم يوقنون
+
+53
+00:07:49,080 --> 00:07:58,660
+هذا بصار من الناس وهده ورحمه وهده ورحمه لقوم
+
+54
+00:07:58,660 --> 00:08:06,350
+يوقنونأم حسب الذين اشتغلوا السيئات أن نجعلهم
+
+55
+00:08:06,350 --> 00:08:16,590
+كالذين آملوا وعملوا الصيف سواء .. سواء نحياهم ..
+
+56
+00:08:16,590 --> 00:08:28,010
+بس مده مده كويس سواء نحياهم سواء نحياهم وماراتهم
+
+57
+00:08:32,270 --> 00:08:37,770
+الله يفتح عليك يقرايا
+
+58
+00:08:37,770 --> 00:08:38,190
+و يصرا
+
+59
+00:08:57,350 --> 00:09:08,250
+ولي تجزا في wow في wow ولي تجزا ولي .. ولي تجزا
+
+60
+00:09:10,900 --> 00:09:18,360
+والتجزا كل نفس بما كسبته لا يخلقه موظف أفرأت من
+
+61
+00:09:18,360 --> 00:09:23,080
+اتخذ إله هو هواب وأضربه الله على علمه وختم على
+
+62
+00:09:23,080 --> 00:09:31,220
+سمعه وقلبه وسب على سمعه وقلبه وجعل على
+
+63
+00:09:31,220 --> 00:09:39,400
+بصره غشا وتم فملو جعل على بصيره غشاوة فما يأتي من
+
+64
+00:09:39,400 --> 00:09:45,740
+بعد الله أفلا أتذكرون؟ وقالوا ما هي إن حياتنا
+
+65
+00:09:45,740 --> 00:09:52,360
+الدنيا نموت ونحيا وما يبقنا إلا الذهب وما لهم بذلك
+
+66
+00:09:52,360 --> 00:09:58,880
+من علم .. وما لهم بذلك من
+
+67
+00:09:58,880 --> 00:10:04,240
+علم .. من علم إنهم إلا يظنون .. قولني عنه الحرب
+
+68
+00:10:04,240 --> 00:10:11,410
+تانيةوإن .. إن .. إن هم .. إن هم إلا يظنون وإذا
+
+69
+00:10:11,410 --> 00:10:18,850
+تتلى عليه آياتنا بينات .. وإذا تتلى عليهم وإذا
+
+70
+00:10:18,850 --> 00:10:24,950
+تتلى عليهم آياتنا بينات إن ما كان حجتهم إلا ما كان
+
+71
+00:10:24,950 --> 00:10:35,720
+حجتهم كمفتوحة ما كان حجتهم إلاما كان حُشتهم إلا أن
+
+72
+00:10:35,720 --> 00:10:44,160
+قالوا أتوا بأبائنا
+
+73
+00:10:44,160 --> 00:10:48,180
+ما كان
+
+74
+00:10:48,180 --> 00:10:55,420
+حُشتهم إلا أن قالوا أتوا بأبائنا قالوا أتوا إلا أن
+
+75
+00:10:55,420 --> 00:11:01,420
+قالوا أتوا بأبائنا عن التقاء ساكنين قالوا
+
+76
+00:11:01,420 --> 00:11:07,650
+أتواما كان حجاتهم إلا أن قالوا أتوا بأبانا .. جيبي
+
+77
+00:11:07,650 --> 00:11:15,150
+.. جيبي الإخفاء أول .. أن قالوا أتوا ..
+
+78
+00:11:15,150 --> 00:11:20,810
+كويس يعني ما كان حجاتهم إلا أن قالوا .. أن قالوا
+
+79
+00:11:20,810 --> 00:11:25,170
+أتوا بأبانا .. صح؟ صح، بس جيبي الحرف المدحر اتين
+
+80
+00:11:25,170 --> 00:11:32,890
+.. قالوا أتوا بأبانا ..ما كانت مجزتهم إلا أن قالوا
+
+81
+00:11:32,890 --> 00:11:37,270
+أنتوا أبا .. بأبائنا إن كنتوا صادقين .. بالمبدل
+
+82
+00:11:37,270 --> 00:11:51,200
+تاني بأبائنا إن كنتوا .. بأبائنا إن كنتوا صادقينقل
+
+83
+00:11:51,200 --> 00:11:57,580
+الله يحييكم ثم يميتكم ثم يجمعكم إلى يوم القيامة لا
+
+84
+00:11:57,580 --> 00:12:03,740
+ريب فيه ولكن أكتر الناس لا يعلمون ولله ملك
+
+85
+00:12:03,740 --> 00:12:09,340
+السماوات والأرض ويوم تقوم الساعة يوم إذ يخسروا
+
+86
+00:12:09,340 --> 00:12:25,570
+المبطلون و ترى كل أمة جاثيةكل أمة
+
+87
+00:12:25,570 --> 00:12:34,830
+تدعى
+
+88
+00:12:34,830 --> 00:12:39,950
+إلى كتابها اليوم تجزون ما كنتم تعملون
+
+89
+00:12:46,310 --> 00:12:54,410
+أقرأ يا نهار بسم
+
+90
+00:12:54,410 --> 00:12:58,730
+الله الرحمن الرحيم بسم الله الرحمن الرحيم يعني
+
+91
+00:12:58,730 --> 00:13:02,970
+اعلى صوتك يا نهار مش ثاني اعشق اعشق اعشق اعشق اعشق
+
+92
+00:13:02,970 --> 00:13:03,730
+اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق
+
+93
+00:13:03,730 --> 00:13:05,570
+اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق
+
+94
+00:13:05,570 --> 00:13:08,190
+اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق
+
+95
+00:13:08,190 --> 00:13:14,210
+اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق اعشق
+
+96
+00:13:14,210 --> 00:13:20,120
+اععليكم بالحق
+
+97
+00:13:20,120 --> 00:13:24,620
+.. ترجعي
+
+98
+00:13:24,620 --> 00:13:31,940
+و قولي على النهار .. اننا كنا نستنفيكم .. نعم ..
+
+99
+00:13:31,940 --> 00:13:36,100
+جاهز؟ بعد انها لقراك
+
+100
+00:13:44,200 --> 00:13:45,600
+ماكنطون
+
+101
+00:14:14,360 --> 00:14:23,520
+وكنتم .. دي بيقول كمقوما مجرمين .. قوما مجرمين
+
+102
+00:14:23,520 --> 00:14:29,640
+وإذا قيل لهم وعد الله حق والساعة لا ريب فيها ..
+
+103
+00:14:29,640 --> 00:14:34,900
+اوصلي .. اوصلي يعني وعد الله حقه والساعته .. وعد
+
+104
+00:14:34,900 --> 00:14:38,140
+الله حقه والساعة لا ريب فيها .. والساعته ..
+
+105
+00:14:38,140 --> 00:14:44,560
+والساعة لا ريب فيها كنتم .. كنتم ندري ما الساعة
+
+106
+00:14:44,890 --> 00:14:53,770
+فانتظنوا ان اضنوا ان اضنوا وما دخلوه مصريقون
+
+107
+00:14:53,770 --> 00:14:56,970
+وبدلوهم
+
+108
+00:14:56,970 --> 00:15:03,670
+سيئات ما عملوه سيئات ما عملوه فحقق بهم ما كانوا
+
+109
+00:15:03,670 --> 00:15:11,450
+فيهم وحقق بهم ما كانوا فيه يستزقون وقيل لهم
+
+110
+00:15:15,200 --> 00:15:22,000
+ننساكم وقيل اليوم ننساكم مش اليوم، اليومة اليومة
+
+111
+00:15:22,000 --> 00:15:27,960
+وقيل اليوم ننساكم كما نسيتم اليوم ننساكم وقيل
+
+112
+00:15:27,960 --> 00:15:37,920
+اليوم ننساكم كما نسيتم لقاء يومكم لقاء لقاء يومكم
+
+113
+00:15:37,920 --> 00:15:39,240
+هذا
+
+114
+00:15:44,460 --> 00:15:53,140
+غنى عنه الحركتان وما لكم وما لكم ناصرين وما لكم
+
+115
+00:15:53,140 --> 00:16:03,880
+ناصرين قدى وما لكم وما لكم ناصرين ذلكم بأنكم
+
+116
+00:16:03,880 --> 00:16:07,900
+اتخدتم ايه اللي .. دي باولش يرفع الشفاوي و بعدين
+
+117
+00:16:07,900 --> 00:16:13,320
+ضم الميل بأنكم ذلكم بأنكم اتخدتم
+
+118
+00:16:15,950 --> 00:16:27,150
+بأنكم .. نهار .. بأنكم تخذتم
+
+119
+00:16:27,150 --> 00:16:39,010
+.. تخذتم .. آيات الله مذوة .. مذوة ووردكم
+
+120
+00:16:40,160 --> 00:16:49,880
+فغرقوا من حياته
+
+121
+00:16:49,880 --> 00:16:59,080
+الدنيا فاللهم لا يخرجوها منها ولا هم يستعبون
+
+122
+00:16:59,590 --> 00:17:05,510
+فلله الحمد رب السماوات .. فلله .. فلله الحمد رب
+
+123
+00:17:05,510 --> 00:17:09,350
+السماوات .. مافيش بس صح بس ارجع وصلك فلله .. فلله
+
+124
+00:17:09,350 --> 00:17:13,810
+الأرض و رب السماوات و رب الأرض و رب العالمين ..
+
+125
+00:17:13,810 --> 00:17:19,290
+مافيش و رب الأرض و رب العالمين .. و له الكبرياء في
+
+126
+00:17:19,290 --> 00:17:21,550
+السماوات .. و له الكبرياء
+
+127
+00:17:26,400 --> 00:17:30,920
+و في السماوات و القرض و هو العزيز الحكيم و هو
+
+128
+00:17:30,920 --> 00:17:38,260
+العزيز الحكيم و هو العزيز الحكيم و هو العزيز
+
+129
+00:17:38,260 --> 00:17:40,480
+الحكيم و هو العزيز الحكيم و هو العزيز الحكيم و هو
+
+130
+00:17:40,480 --> 00:17:40,700
+العزيز الحكيم و هو العزيز الحكيم و هو العزيز
+
+131
+00:17:40,700 --> 00:17:45,260
+الحكيم و هو العزيز الحكيم و هو العزيز الحكيم و هو
+
+132
+00:17:45,260 --> 00:17:54,440
+العزيز الحكيم و هو العزيز الحكيم و هو العزيز الحك
+
+133
+00:18:01,230 --> 00:18:10,970
+كل أمة تدعى إلى كتابها اليوم .. كل أمة تدعى إلى
+
+134
+00:18:10,970 --> 00:18:15,150
+كتابها اليوم .. تدعى
+
+135
+00:18:15,150 --> 00:18:22,130
+إلى .. كل أمة تدعى إلى كتابها اليوم تجيزون ما كنتم
+
+136
+00:18:22,130 --> 00:18:34,030
+تعملونهذا كتابنا ينطق عليكم بالحق إننا كنا نستنتق
+
+137
+00:18:34,030 --> 00:18:41,900
+ما كنتم تعملونفأما الذين آمنوا وعملوا الصالحات
+
+138
+00:18:41,900 --> 00:18:50,320
+فيدخلهم ربهم في رحمته، ذلك هو الفوز المبين وأما
+
+139
+00:18:50,320 --> 00:18:56,300
+الذين كفروا، أفلم تكنوا الآيات كتلة عليكم،
+
+140
+00:18:56,300 --> 00:19:05,930
+فاستكبرتم، فاستكبرتم وكنتم قوما مجرمينوإذا قيل إن
+
+141
+00:19:05,930 --> 00:19:13,190
+وعد الله حقه و الساعة لا عيب فيها، قلت ماندري ما
+
+142
+00:19:13,190 --> 00:19:17,430
+الساعة إن ضنوا إلا ضنوا
+
+143
+00:19:28,960 --> 00:19:35,880
+لو وما نحن بالمصطلح استيقنين وبدالهم سيئات ما
+
+144
+00:19:35,880 --> 00:19:43,060
+عملوا وحاق بهم ما كانوا بيه يستهزمون وقيل اليوم
+
+145
+00:19:43,060 --> 00:19:52,860
+ننساكم كما نسيتم لقاء يومكم هذا كما نسيتم لقاء
+
+146
+00:19:52,860 --> 00:19:57,560
+يومكم هذا ومأواكم الدار وما لكم
+
+147
+00:20:00,190 --> 00:20:08,210
+الناصرين. ذلكم بأنكم اتخذتم اي .. اتخذتم ايات الله
+
+148
+00:20:08,210 --> 00:20:15,610
+حذفا وغرزكم الحياة الدنيا فاليوم لا يخرجون منها
+
+149
+00:20:15,610 --> 00:20:23,350
+ولا هم يستعتقونفلله الحمد ورب السماوات ورب الأرض
+
+150
+00:20:23,350 --> 00:20:31,270
+ورب العالمين وله الكبرياء في السماوات والأرض وهو
+
+151
+00:20:31,270 --> 00:20:35,390
+العزيز والحجير بظهوم لها إيه كويس؟ هو هو وهو
+
+152
+00:20:35,390 --> 00:20:40,970
+العزيز والحجير الله أكبر الله أكبر إيش هالقناة؟
+
+153
+00:20:53,150 --> 00:21:16,330
+تعاصر في الضخان اه تقراي
+
+154
+00:21:16,330 --> 00:21:20,150
+اسرائيل بسم
+
+155
+00:21:20,150 --> 00:21:33,260
+الله الرحمن الرحيمحميم والكتاب المبين إنا أنفله في
+
+156
+00:21:33,260 --> 00:21:44,800
+ليلة مباركة إنا كنا منفلين فيها يفرق كل .. فيها
+
+157
+00:21:44,800 --> 00:21:57,330
+يفرق .. فيها يفرق كل أمر حكيمأمرا من عندنا إنا كنا
+
+158
+00:21:57,330 --> 00:22:02,410
+مرسلين رحمة
+
+159
+00:22:02,410 --> 00:22:14,650
+من ربك إنه هو السميع العليم رب السماوات والأرضوما
+
+160
+00:22:14,650 --> 00:22:26,050
+بينهما إن .. إن كنتم موقنين لا إله إلا هو يحيي
+
+161
+00:22:26,050 --> 00:22:38,410
+ويميت ربكم ورب آبائكم الأولين بل هم في شك يلعبون
+
+162
+00:22:38,890 --> 00:22:53,470
+فارتق بيوم تأتي السماء بدخان مبين يغش الناس
+
+163
+00:22:53,470 --> 00:23:04,230
+هذا عذاب عليم رب نكشف عن العذاب إنا مؤمنين مؤمنون
+
+164
+00:23:04,230 --> 00:23:12,800
+أنا له مثلأن لهم الذكرا وقد جاءهم .. أن لهم الذكرا
+
+165
+00:23:12,800 --> 00:23:22,740
+وقد .. أن لهم الذكرا وقد جاءهم رسول مبين ثم تولوا
+
+166
+00:23:22,740 --> 00:23:34,610
+عنه وقالوا معلمفقالوا معلم مجنون فقالوا معلم مجنون
+
+167
+00:23:34,610 --> 00:23:44,330
+إنكاشفوا العذاب قليلا إنكاشفوا العذاب إنكاشفوا
+
+168
+00:23:44,330 --> 00:23:54,200
+العذاب قليلا إنكم عائدون يوم نفسكيوم نبقش البقشة
+
+169
+00:23:54,200 --> 00:24:03,580
+الكبرى يوم نبقش البقشة الكبرى اننا منتقمون الله
+
+170
+00:24:03,580 --> 00:24:08,280
+يفتح عليها اقرأ يا صبري
+
+171
+00:24:11,050 --> 00:24:17,450
+من الله الرحمن الرحيم ولقد فتن قبلهم قوم فرعون
+
+172
+00:24:17,450 --> 00:24:30,670
+وجاءهم رسول كريم ان أدوا الي عباد الله ان أدوا
+
+173
+00:24:30,670 --> 00:24:36,410
+الي عباد الله اني لكم رسول أمين
+
+174
+00:24:39,310 --> 00:24:45,170
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+175
+00:24:45,170 --> 00:24:47,850
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+176
+00:24:47,850 --> 00:24:48,090
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+177
+00:24:48,090 --> 00:24:48,690
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+178
+00:24:48,690 --> 00:24:54,630
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+179
+00:24:54,630 --> 00:24:56,870
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+180
+00:24:56,870 --> 00:24:56,890
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+181
+00:24:56,890 --> 00:24:57,250
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+182
+00:24:57,250 --> 00:24:59,790
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+183
+00:24:59,790 --> 00:25:07,330
+و قال لا تعالوا على الله و قال لا تعالوا على الله
+
+184
+00:25:07,630 --> 00:25:19,730
+وإني عدت بربى وربكم أترجمون وإن
+
+185
+00:25:19,730 --> 00:25:25,790
+لم تؤمنوا لي
+
+186
+00:25:25,790 --> 00:25:38,230
+فاتسلون فدعى ربه أن هؤلاء قوم مجرمونفأسرق .. فأسرق
+
+187
+00:25:38,230 --> 00:25:42,110
+يا عبادي .. فأسرق يا عبادي .. فأسرق يا عبادي .. لأ
+
+188
+00:25:42,110 --> 00:25:44,950
+مافيش يعني الرقم اكسره فقط فأسرق يا عبادي .. أسرق
+
+189
+00:25:44,950 --> 00:25:52,650
+يا عبادي ليلة قيلة إنكم متبعون و أترك البحر .. و
+
+190
+00:25:52,650 --> 00:25:56,570
+أترك البحر .. و أترك البحر رهوان .. نمزق وصل يا
+
+191
+00:25:56,570 --> 00:26:01,950
+سابريا و أترك البحر .. و أترك البحر رهوان إنهم
+
+192
+00:26:01,950 --> 00:26:12,480
+جدهم مغرقونكم تركوا من جنة وعيون وزروع ومقام كريم
+
+193
+00:26:12,480 --> 00:26:19,660
+ونعمتين كانوا .. ونعمتين كانوا .. ونعمتين كانوا ..
+
+194
+00:26:19,660 --> 00:26:27,420
+ونعمتين كانوا فيها فاتين كذلك وأورثناها قوما آخرين
+
+195
+00:26:27,420 --> 00:26:32,450
+وأورثناها .. أجيب الحرف من الدب خلاصوأورثناها قوما
+
+196
+00:26:32,450 --> 00:26:42,130
+آخرين فما بكت عليهم السماء والأرض وما كانوا مغضرين
+
+197
+00:26:42,130 --> 00:26:50,870
+ولقد رجينا بني إسرائيل من العذاب المهيم من فرعون
+
+198
+00:26:50,870 --> 00:26:57,430
+إنه كان عليا من المسرفين ولقد اختارناهم على علم
+
+199
+00:26:57,430 --> 00:27:04,510
+على العالمينو آتيناهم من الآيات ما فيه بلاء .. و
+
+200
+00:27:04,510 --> 00:27:12,050
+آتيناهم من الآيات ما فيه بلاء مبين الله يفتح حاله
+
+201
+00:27:12,050 --> 00:27:22,690
+سجلت
+
+202
+00:27:22,690 --> 00:27:26,230
+اسمك يا عزيزي؟ ايه الشعب التناشي؟
+
+203
+00:27:30,920 --> 00:27:34,300
+شايف يامان عبد الراجل؟ لأ يامان الحماية اه يامان
+
+204
+00:27:34,300 --> 00:27:41,900
+الحماية بجانبك
+
+205
+00:27:41,900 --> 00:27:52,620
+عابير عبد الراجل عابير اليوم؟ اقرأ
+
+206
+00:27:52,620 --> 00:27:53,180
+يا عابير يا
+
+207
+00:27:57,590 --> 00:28:05,330
+إن أولئك لا يقولون إن هي إلا موتتنا الأولى وما ..
+
+208
+00:28:05,330 --> 00:28:11,430
+وما نحن بمشزين وما
+
+209
+00:28:11,430 --> 00:28:21,650
+نحن بمشارين فاتوا بأبائنا إن كنتوا صادقينأهم خير
+
+210
+00:28:21,650 --> 00:28:26,490
+أم قوم تبعوا
+
+211
+00:28:26,490 --> 00:28:30,570
+الذين قبلهم؟
+
+212
+00:28:30,570 --> 00:28:43,110
+أهم خير أم قوم تبعوا
+
+213
+00:28:43,110 --> 00:28:51,820
+الذينبعيوه الذين من يوم قبلهم أخلقناهم إنهم كانوا
+
+214
+00:28:51,820 --> 00:28:59,080
+مجرمين وما خلقنا السماوات والأرض وما بينهما لاعبين
+
+215
+00:28:59,080 --> 00:29:07,100
+ما خلقناهما إلا بالحق ولكن أكثرهم لا يعرفوا ولكن
+
+216
+00:29:07,100 --> 00:29:10,040
+أكثرهم ولكن
+
+217
+00:29:14,000 --> 00:29:21,600
+إن يوم الفصل
+
+218
+00:29:21,600 --> 00:29:24,980
+نقاتهم
+
+219
+00:29:24,980 --> 00:29:32,620
+أجمعين يوم لا يغني مودة عن مودة شديد
+
+220
+00:29:34,790 --> 00:29:49,310
+يوم لا يبني مولا عن مولا
+
+221
+00:29:49,310 --> 00:29:57,410
+شيئا ولا هم ينصرون إلا من رحم الله إنه هو العزيز
+
+222
+00:29:57,410 --> 00:29:57,690
+رحمه
+
+223
+00:30:04,610 --> 00:30:14,410
+ليغضي فالبطون كغني الحميم خلوه فاكلوه
+
+224
+00:30:14,410 --> 00:30:20,870
+إلى سواء الجحيم
+
+225
+00:30:20,870 --> 00:30:24,150
+ثم
+
+226
+00:30:24,150 --> 00:30:33,950
+صبوا فوق رأسي من عذاب الحميمنلعب بالحنين ضغ انك
+
+227
+00:30:33,950 --> 00:30:42,030
+أنت
+
+228
+00:30:42,030 --> 00:30:58,270
+العزيز الكريم ان هذا ما كنتم بيتمتعون كنتم
+
+229
+00:30:58,270 --> 00:30:59,190
+بيه
+
+230
+00:31:28,970 --> 00:31:36,920
+خلوني اعنوهجناه .. نقول جنه و اجيب الاطراف في جناه
+
+231
+00:31:36,920 --> 00:31:47,340
+و عيون يلبسون من صندس
+
+232
+00:31:47,340 --> 00:31:52,740
+و استبرق متقابلين
+
+233
+00:32:01,020 --> 00:32:10,600
+واستبرق المتقابلين كذلك وزوجناهم في قرنين يدعون
+
+234
+00:32:10,600 --> 00:32:19,720
+فيها يدعون فيها بكل فاتحة آمنين لا يضغطون فيها
+
+235
+00:32:19,720 --> 00:32:27,460
+الموت إلا الموتة الأولى ووقعهم عذاب الجحيم فضل من
+
+236
+00:32:27,460 --> 00:32:28,780
+ربك كذب
+
+237
+00:32:42,700 --> 00:32:45,820
+الله يفتح حالته
+
+238
+00:33:12,290 --> 00:33:23,690
+عشان ده درسك عشان ده درسك عشان
+
+239
+00:33:23,690 --> 00:33:27,510
+ده درسك عشان ده درسك عشان ده درسك عشان ده درسك
+
+240
+00:33:27,510 --> 00:33:29,390
+عشان ده درسك عشان ده درسك عشان ده درسك
+
+241
+00:33:32,880 --> 00:33:39,900
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+242
+00:33:39,900 --> 00:33:44,840
+الرحيم حاميم
+
+243
+00:33:52,780 --> 00:34:02,360
+حاميم والكتاب المبين إنا جعلناه قرآنا عربيا لعلكم
+
+244
+00:34:02,360 --> 00:34:13,410
+تعقلون وإنه في أمناالكتاب لدينا لعلي حكيم أفنضرب
+
+245
+00:34:13,410 --> 00:34:23,350
+عنكم الذكر صفحا أن كنتم قوما مسرفين وكم أرسلنا من
+
+246
+00:34:23,350 --> 00:34:33,010
+نبي في الأولين وما يأتيهم من نبي إلا كانوا به
+
+247
+00:34:33,010 --> 00:34:35,010
+يستهزئون
+
+248
+00:34:37,000 --> 00:34:47,880
+فأهلكنا أشد منهم بطشا ومضى مثل الأولين ولئن سألتهم
+
+249
+00:34:47,880 --> 00:34:55,640
+من خلق السماوات والأرضمن خلق السماوات والأرض ليقول
+
+250
+00:34:55,640 --> 00:35:03,800
+إن خلقهن العزيز العليم الذي جعل لكم الأرض مهدا
+
+251
+00:35:03,800 --> 00:35:11,800
+وجعل لكم فيها سبولا لعلكم تهتدون والذي .. والذي
+
+252
+00:35:11,800 --> 00:35:23,400
+نزل من السماء .. والذي نزل ..والذي نزل من السماء
+
+253
+00:35:23,400 --> 00:35:30,600
+ماء بقدر و الذي نزل من السماء
+
+254
+00:35:37,500 --> 00:35:47,920
+بقدر فأنشرنا به بلدة ميتة كذلك تخرجون والذي خلق
+
+255
+00:35:47,920 --> 00:35:56,420
+الأزواج كلها وجعل لكم من الفلك والأنعام ما تركبون
+
+256
+00:35:56,420 --> 00:36:05,700
+لتستووا على ظهوره ثم تذكروا نعمة ربكمثم تذكروا
+
+257
+00:36:05,700 --> 00:36:12,520
+نعمة ربكم إذا استويتم عليه وتقولوا سبحان الذي سخر
+
+258
+00:36:12,520 --> 00:36:19,040
+لنا هذا
+
+259
+00:36:19,040 --> 00:36:30,100
+وما كنا له مقرنين وإنا إلى ربنا لمن قلبون
+
+260
+00:36:45,240 --> 00:36:51,880
+هيبقى هيبقى هيبقى .. فلمّا آسفون .. فلمّا آسفون
+
+261
+00:36:51,880 --> 00:36:56,440
+انتقمنا منهم فأغرقناهم أشمعين فقمنا اغار منهم
+
+262
+00:36:56,440 --> 00:37:04,380
+فأغرقناهم انتقمنا منهم فأغرقناهم أشمعين فجعلناهم
+
+263
+00:37:04,380 --> 00:37:13,000
+سلفه ومثلا للآخرين للآخرين .. للآخرين ولمّا ضربت
+
+264
+00:37:13,440 --> 00:37:19,440
+ولمّا ضرب ابن مريم مثلا إذا قومك منه يصدون .. إذا
+
+265
+00:37:19,440 --> 00:37:26,240
+قومك .. إذا قومك منه يصدون .. ليش بدي بيخاف نون؟
+
+266
+00:37:26,240 --> 00:37:36,360
+منه يصدون .. منه يصدون .. يصدون .. يصدون .. وقالوا
+
+267
+00:37:36,360 --> 00:37:43,210
+آيات أخيهم هو ما ضربوه لك إلا جدالة إلا جدالةإلا
+
+268
+00:37:43,210 --> 00:37:49,430
+جدلا بل هم قوم قصمهم أنه إلا عبد أنعمنا عليه
+
+269
+00:37:49,430 --> 00:37:56,630
+واجعلناه مثلا لبني إسرائيل واجعلناه مثلا لبني
+
+270
+00:37:56,630 --> 00:38:06,010
+إسرائيل و لو نشاء لجعلنا منكم ملائكة ملائكة في
+
+271
+00:38:06,010 --> 00:38:12,310
+الأرض يخلقون الله يفتح عليه يالا يا مريم
+
+272
+00:38:15,570 --> 00:38:24,770
+بسم الله الرحمن الرحيم وإنه لعلم للساعة فلا تنهرن
+
+273
+00:38:24,770 --> 00:38:38,590
+بها واتبعون هذا صراط مستقيم ولا يصدنكم الشيطان إنه
+
+274
+00:38:38,590 --> 00:38:41,690
+لكم عدو مبين
+
+275
+00:38:43,380 --> 00:38:59,900
+ولما جاء عيسى بالبينات قال قد جئتكم بالحكمة
+
+276
+00:38:59,900 --> 00:39:04,600
+ولمبين لكم بعض الذي تختلفون فيه
+
+277
+00:39:08,290 --> 00:39:16,710
+قال قد جئتكم بالحكمة ولأبين لكم بعض الذي تختلفون
+
+278
+00:39:16,710 --> 00:39:26,490
+فيه فاتقوا الله وأطيعون إن الله هو ربي وربكم
+
+279
+00:39:26,490 --> 00:39:32,670
+فاعقدوا هذا صراط مستقيم
+
+280
+00:39:34,360 --> 00:39:42,840
+فاختلف الأحزاب من بينهم فويل للذين ظلموا من عذاب
+
+281
+00:39:42,840 --> 00:39:57,040
+يوم أليم هل ينظرون إلى الساعة تأتيهم بغتة وهم لأهل
+
+282
+00:39:57,040 --> 00:40:06,160
+ينظرون إلى الساعة تأتيهم بغتته و هم لا يشعرون
+
+283
+00:40:12,040 --> 00:40:23,280
+هل ينظرون إلى الساعة أن تأتيهم بغتة و هم لا يشعرون
+
+284
+00:40:23,280 --> 00:40:26,380
+الأخلاق
+
+285
+00:40:26,380 --> 00:40:31,300
+يومئذ بعضهم لبعض عدون
+
+286
+00:40:33,570 --> 00:40:44,870
+يا عباد لا خوف عليكم اليوم ولا أنتم تحزنون الذين
+
+287
+00:40:44,870 --> 00:40:54,710
+آمنوا بآياتنا وكانوا مسلمين ادخلوا الجنة أنتم
+
+288
+00:40:54,710 --> 00:41:07,110
+وأزواجكم تحبرونيقاف عليهم
+
+289
+00:41:07,110 --> 00:41:19,230
+بصحاف من ذهب وكواب وفيها ماذا اشتهي الأنفس وتلد
+
+290
+00:41:19,230 --> 00:41:26,890
+الأعين وانتم فيها خالدون الله أكبر عليك بسم الله
+
+291
+00:41:26,890 --> 00:41:27,110
+الرحمن الرحيم
+
+292
+00:41:31,780 --> 00:41:37,500
+تقرا يا إسراء؟ بسم الله الرحمن الرحيم و تلك الجنة
+
+293
+00:41:37,500 --> 00:41:42,360
+التي أورستموها
+
+294
+00:41:42,360 --> 00:41:50,320
+بما كنتم تعملون بما كنتم تعملون لكم فيها فاكهة
+
+295
+00:41:50,320 --> 00:42:00,180
+كتيرة منها تأكلونإن المجرمين في عداد جهنم خالدون
+
+296
+00:42:00,180 --> 00:42:05,160
+لا يفتروا
+
+297
+00:42:05,160 --> 00:42:12,220
+عنهم وهم فيه مبلسون وما ظلمناهم ولكن .. ولكن كانوا
+
+298
+00:42:12,220 --> 00:42:13,380
+هم الظالمين
+
+299
+00:42:18,770 --> 00:42:23,710
+ونادوا يا مالك .. ونادوا .. ونادوا يا مالك ..
+
+300
+00:42:23,710 --> 00:42:29,190
+ونادوا يا مالك .. ونادوا يا مالك ليقضي .. يا مالك
+
+301
+00:42:29,190 --> 00:42:34,470
+.. ونادوا يا مالك ليقضي .. ليقضي علينا ربك ..
+
+302
+00:42:34,470 --> 00:42:39,970
+مافيش يعني، الظهر مكسور، ليقضي علينا ربك ليقضي ..
+
+303
+00:42:39,970 --> 00:42:45,570
+ليقضي .. ليقضي علينا ربك، مافيش يعني، ليقضي ..
+
+304
+00:42:45,570 --> 00:42:54,800
+ليقضي علينا ..ليقضي علينا .. ليقضي علينا .. ليقضي
+
+305
+00:42:54,800 --> 00:43:00,400
+علينا .. ليقضي علينا .. ليقضي علينا ربك قال .. ربك
+
+306
+00:43:00,400 --> 00:43:05,000
+.. ربك قال ان .. لأ ربك ديك تقصري .. ديك تجفي قولي
+
+307
+00:43:05,000 --> 00:43:13,080
+ربك ليقضي علينا ربك .. ربك .. ليقضي علينا .. ليقضي
+
+308
+00:43:13,080 --> 00:43:22,460
+علينا ربك ..ليقضي علينا ربك .. ليقضي علينا ربك ..
+
+309
+00:43:22,460 --> 00:43:28,360
+ليقضي علينا ربك .. ليقضي علينا ربك .. ليقضي علينا
+
+310
+00:43:28,360 --> 00:43:34,820
+ربك .. ليقضي علينا ربك .. ليقضي علينا ربك .. ليقضي
+
+311
+00:43:34,820 --> 00:43:39,620
+علينا ربك .. ليقضي علينا ربك .. ليقضي علينا ربك ..
+
+312
+00:43:39,620 --> 00:43:43,040
+ليقضي علينا ربك .. ليقضي علينا ربك .. ليقضي علينا
+
+313
+00:43:43,040 --> 00:43:47,010
+ربك .. ليقضي علينا ربك .. ليقضيفقد جئناكم بالحق
+
+314
+00:43:47,010 --> 00:43:53,190
+ولكن أكتركم للحق كارهون أبرموا
+
+315
+00:43:56,160 --> 00:44:02,140
+أم أبرموا أمرا فإننا مبرمون .. مبرمون .. مبرم ..
+
+316
+00:44:02,140 --> 00:44:09,360
+فإننا مبرمون أم يحسبون أن .. أم يحسبون .. أم يحسب
+
+317
+00:44:09,360 --> 00:44:16,300
+.. أم يحسبون أننا لا نسمع سرهم والجواهم بل ورسلنا
+
+318
+00:44:16,300 --> 00:44:22,520
+لابلى و رسولنا لديهم يكتبون .. بلى و رسولنا لديهم
+
+319
+00:44:22,520 --> 00:44:23,800
+يكتبون .. بلى و رسولنا لديهم يكتبون .. بلى و
+
+320
+00:44:23,800 --> 00:44:24,000
+رسولنا لديهم يكتبون .. بلى و رسولنا لديهم يكتبون
+
+321
+00:44:24,000 --> 00:44:24,420
+.. بلى و رسولنا لديهم يكتبون .. بلى و رسولنا لديهم
+
+322
+00:44:24,420 --> 00:44:28,540
+يكتبون .. بلى و رسولنا لديهم يكتبون .. بلى و
+
+323
+00:44:28,540 --> 00:44:33,060
+رسولنا لديهم يكتبون .. بلى و رسولنا لديهم يكتبون
+
+324
+00:44:33,060 --> 00:44:36,680
+.. بلى و رسولنا لديهم يكتبون .. بلى و رسولنا لديهم
+
+325
+00:44:36,680 --> 00:44:40,520
+يكتبون .. بلى و رسولنا لديهم يكتبون .. بلى و
+
+326
+00:44:40,520 --> 00:44:48,690
+رسولنا لديهم يكتبون ..فأنا أول العابدين، سبحان رب
+
+327
+00:44:48,690 --> 00:44:55,230
+.. سبحان رب السماوات والأرض، رب العرش، عما يطفون،
+
+328
+00:44:55,230 --> 00:45:00,950
+فبرهم يخوضوا ويلعبوا ويلعبوا حتى .. حتى يلاقوا
+
+329
+00:45:00,950 --> 00:45:06,730
+يومهم اللي .. يومهم .. يوم .. حتى يلاقوا يومهم ..
+
+330
+00:45:06,730 --> 00:45:12,030
+مش فخمة، مش يلاقوا .. ملاقوا .. حتى يلاقوا يومهم
+
+331
+00:45:12,030 --> 00:45:23,290
+اللي .. يومهم .. يومهم ..يومه .. يومهم .. فذرهم
+
+332
+00:45:23,290 --> 00:45:29,890
+يخوضوا ويلعبوا حتى يلاقوا يومهم يومهم .. يومهم
+
+333
+00:45:29,890 --> 00:45:35,410
+اللي .. يومهم .. يومهم .. يومهم .. يومهم .. يومهم
+
+334
+00:45:35,410 --> 00:45:40,530
+.. يومهم .. يومهم .. يومهم .. يومهم .. يومهم ..
+
+335
+00:45:40,530 --> 00:45:40,850
+يومهم .. يومهم .. يومهم .. يومهم .. يومهم .. يومهم
+
+336
+00:45:40,850 --> 00:45:42,610
+يومهم .. يومهم .. يومهم .. يومهم .. يومهم .. يومهم
+
+337
+00:45:42,610 --> 00:45:43,370
+.. يومهم .. يومهم .. يومهم .. يومهم .. يومهم ..
+
+338
+00:45:43,370 --> 00:45:43,430
+يومهم .. يومهم .. يومهم
+
+339
+00:45:48,090 --> 00:45:56,410
+سماء إله وفي الأرض إله وهو الحكيم العليم وستجرف
+
+340
+00:45:56,410 --> 00:46:03,290
+الذي له المُلف السماوات والأرض وما بينهما وعنده
+
+341
+00:46:03,290 --> 00:46:12,050
+علم الساعة وعنده علم الساعة وإليه ترجعون ولا يملك
+
+342
+00:46:12,050 --> 00:46:14,010
+الذين يجعون منه
+
+343
+00:46:26,430 --> 00:46:34,490
+ولئن سألتهم اظهار
+
+344
+00:46:34,490 --> 00:46:43,730
+من خلقهمولإن سألتهم ما خلقهم ليقولوا .. ليقولوا إن
+
+345
+00:46:43,730 --> 00:46:52,930
+الله فأنهم فخون و .. و قيل يا ربي .. و قيل يا ربي
+
+346
+00:46:52,930 --> 00:47:01,850
+إنها .. إن هؤلاء قوم لا يفهمون فاصبح عنهم و قل
+
+347
+00:47:01,850 --> 00:47:05,090
+سلام فسوف يعلمون
+
+348
+00:47:09,260 --> 00:47:11,920
+افتح على الصورة في الصورة اقرأ ايه تاني يعني ايه
+
+349
+00:47:11,920 --> 00:47:22,120
+تاني بسم
+
+350
+00:47:22,120 --> 00:47:30,080
+الله الرحمن الرحيم حامي لأ مش حامي حامي حركتين فقط
+
+351
+00:47:30,080 --> 00:47:33,080
+حامي حامي
+
+352
+00:47:37,610 --> 00:47:43,750
+لأ مد السين أكتر سينقاف
+
+353
+00:47:43,750 --> 00:47:55,470
+عين عين سينقاف كذلك يوحي إليك و إلى الذين من قبلك
+
+354
+00:47:55,470 --> 00:48:03,990
+الله العزيز الحكيم له ما في السماوات و ما في الأرض
+
+355
+00:48:03,990 --> 00:48:10,470
+و هو اللانيل العظيمالتكاب السماوات يتفطرن ..
+
+356
+00:48:10,470 --> 00:48:17,290
+يتفطرن من فوقهم والملائكة
+
+357
+00:48:17,290 --> 00:48:26,230
+يصفحون بحمد ربهم ويتقفلو يستغفرون لمن في الأرض لمن
+
+358
+00:48:26,230 --> 00:48:34,370
+في الأرض لمن في الأرض ألا إن الله هو الغفور الرحيم
+
+359
+00:48:34,370 --> 00:48:45,130
+والذين اتخذوا من دونه أولياء الله الله حفيظ عليهم
+
+360
+00:48:45,130 --> 00:48:56,500
+وما أنت عليهم بوتيك الله يفتح عناقرأ يالا بسم
+
+361
+00:48:56,500 --> 00:49:08,440
+الله بسم الله كمان شفايا كلنا بناخدها بسم
+
+362
+00:49:08,440 --> 00:49:15,500
+الله الرحمن الرحيم وكذلك أوحينا اليك قرآن عربي
+
+363
+00:49:15,500 --> 00:49:36,210
+لتنذرهم للقراءة لتنذرهملتنذر أم القرى ومن حولها
+
+364
+00:49:36,210 --> 00:49:44,170
+ومن حولها وتنذر يوم الجمع لا ريب فيه فريقهم في
+
+365
+00:49:44,170 --> 00:49:53,920
+الجنة وفريقهم ..فريق في الجنة وفريق في السعير ولو
+
+366
+00:49:53,920 --> 00:50:04,700
+شاء الله لجعلهم همته واحدة ولكن يدخل من يشاء في
+
+367
+00:50:04,700 --> 00:50:12,260
+رحمته والظالمون ما لهم وليهم ولا نصير ما لهم
+
+368
+00:50:14,190 --> 00:50:23,570
+والظالبون ما لهم ولي ولا نصير أن اتخذوا من دومه
+
+369
+00:50:23,570 --> 00:50:31,770
+أولياء فللقلق الله هو الولي و الله هو الولي و هو
+
+370
+00:50:31,770 --> 00:50:38,760
+يحيي الموت و هو يحيي الموتفالله هو الولي وهو يحيي
+
+371
+00:50:38,760 --> 00:50:50,180
+الموتى وهو على كل شي قدير وما اختلفتم فيه
+
+372
+00:50:50,180 --> 00:50:55,500
+فحكمه
+
+373
+00:50:55,500 --> 00:51:04,730
+إلى الله ذلكم الله ربي عليه توكلت وإليه القنينفاضر
+
+374
+00:51:04,730 --> 00:51:12,750
+السماوات والأرض جعل لكم
+
+375
+00:51:12,750 --> 00:51:16,830
+من أنفسكم
+
+376
+00:51:16,830 --> 00:51:18,010
+أزواجا
+
+377
+00:51:22,070 --> 00:51:31,310
+فاطر السماوات والأرض جعل لكم من أنفسكم أزواجا ومن
+
+378
+00:51:31,310 --> 00:51:39,170
+الأنعان أزواجا جعل
+
+379
+00:51:39,170 --> 00:51:46,070
+لكم من .. جعل لكم من أنفسكم أزواجا ومن الأنعان من
+
+380
+00:51:46,070 --> 00:51:47,430
+أنفسكم
+
+381
+00:51:51,650 --> 00:51:57,870
+جعل لكم من أنفسكم أزواجا .. من أنفسكم أزواجا زي
+
+382
+00:51:57,870 --> 00:52:07,810
+الاخفاء الأول من أنفسكم جعل لكم من أنفسكم أزواجا
+
+383
+00:52:07,810 --> 00:52:15,150
+ومن الأنعان أزواجا يدرعكم .. أزواجا يدرعكم ومن
+
+384
+00:52:15,150 --> 00:52:22,290
+الأنعان أزواجا يدرعكم .. يدرعكمو من الأنعان أزواجا
+
+385
+00:52:22,290 --> 00:52:32,950
+يدرأكم فيه
+
+386
+00:52:32,950 --> 00:52:39,990
+ليس كمثله شيء وهو السميع
+
+387
+00:52:39,990 --> 00:52:47,910
+البصير الله يفتح عليه، ترأي هنا؟له مقاليد السماوات
+
+388
+00:52:47,910 --> 00:52:52,950
+والأرض يبسط الرزقى .. الرزقى .. يبسط الرزقى ..
+
+389
+00:52:52,950 --> 00:52:58,650
+يبسط الرزقى .. يبسط الرزقى لمن يشاء .. لمن يشاء ..
+
+390
+00:52:58,650 --> 00:53:05,850
+لمن يشاء ويقدر .. ويقدر .. ويقدر .. لمن يشاء ويقدر
+
+391
+00:53:05,850 --> 00:53:15,500
+.. لمن يشاء ويقدر إنه بكل شيء ناليمشرع لكم من
+
+392
+00:53:15,500 --> 00:53:23,880
+الدين ما وصى
+
+393
+00:53:23,880 --> 00:53:37,380
+به نوحا والذي أوحىنوحى والذى
+
+394
+00:53:37,380 --> 00:53:42,940
+أوحينا
+
+395
+00:53:42,940 --> 00:53:47,220
+اليك وما وصينا به إبراهيم
+
+396
+00:53:49,690 --> 00:53:57,390
+وما وصينا به إبراهيم .. به إبراهيم وموسى وعيسى
+
+397
+00:53:57,390 --> 00:54:06,250
+إبراهيم وموسى وعيسى أن أقيم الدين ولا .. وعيسى أن
+
+398
+00:54:06,250 --> 00:54:12,330
+.. وعيسى أن أقيم الدين ولا تتفرقوا
+
+399
+00:54:16,670 --> 00:54:23,930
+لأ ماشي معاك ما تدعوهم
+
+400
+00:54:23,930 --> 00:54:35,770
+اليه
+
+401
+00:54:35,770 --> 00:54:43,530
+اللهالله يشتبئ ال .. يشتبئ ال .. الله يجتبي إليه
+
+402
+00:54:43,530 --> 00:54:47,850
+الله يشتبئ إليه من .. مد .. مد المدة من خاصة الله
+
+403
+00:54:47,850 --> 00:54:54,390
+يشتبئ إليه من يشاء .. من يشاء .. من يشاء ويهدي
+
+404
+00:54:54,390 --> 00:55:01,070
+إليه مين .. مين ينيب .. مين ينيب .. مين ينيب وما
+
+405
+00:55:01,070 --> 00:55:05,530
+تفرقوا إلا من .. مين .. مد المدة يا عزيزيوما
+
+406
+00:55:05,530 --> 00:55:13,910
+تفرقوا إلا ما .. من بعد ما جاءهم ال .. ما جاءهم
+
+407
+00:55:13,910 --> 00:55:20,390
+العلم ما جاءهم العلم بغيا .. بغيا بينهم .. بغيا
+
+408
+00:55:20,390 --> 00:55:29,370
+بينهم ولولا كلمة سبقت من ربهم ولولا كلمة سبقتولولا
+
+409
+00:55:29,370 --> 00:55:41,370
+كلمة سبقت من ربك الإله إلى أجن مسمى
+
+410
+00:55:41,370 --> 00:55:53,170
+لقضى بينهم وإن الذين أورثوا الكتاب من بعدهم لفي شك
+
+411
+00:55:53,170 --> 00:55:54,770
+منه مريم
+
+412
+00:55:59,950 --> 00:56:06,050
+اقرأ يا رواندي اقرأ من أول الصفة فاضل السماوات
+
+413
+00:56:06,050 --> 00:56:12,690
+والأرض فاضل السماوات والأرض جعل لكم من أنفسكم
+
+414
+00:56:12,690 --> 00:56:19,250
+أذواجا ومن الأنعان أذواجا ومن الأنعان أذواجا
+
+415
+00:56:19,250 --> 00:56:28,080
+يضرؤكم فيه يضرؤكم فيهليس كمثلي شيء و هو السامع و
+
+416
+00:56:28,080 --> 00:56:33,760
+البصير له مقاليد السماوات و الأرض يبسطوا الرزق
+
+417
+00:56:33,760 --> 00:56:37,060
+يبسطوا
+
+418
+00:56:37,060 --> 00:56:40,640
+الرزق لمن يشاء و يقدر
+
+419
+00:56:43,940 --> 00:56:51,420
+بكل شيء عليم شرع لكم من الدين ما وصى بيه نوحه و
+
+420
+00:56:51,420 --> 00:56:57,300
+اللى بيه نوحه و اللى بيه نوحه و اللى بيه نوحه و
+
+421
+00:56:57,300 --> 00:57:03,020
+اللى اوحينا اليك و ما وصينا بيه إبراهيم
+
+422
+00:57:04,950 --> 00:57:21,050
+به إبراهيم وموسى وعيسى أن أقيم
+
+423
+00:57:21,050 --> 00:57:27,930
+الدين ولا تتفرقوا بكفرة على المشركين ما تدعوهم
+
+424
+00:57:27,930 --> 00:57:35,570
+إليه الله يشتري إليه من يشارما يشاء .. جيبوا
+
+425
+00:57:35,570 --> 00:57:45,830
+الأبران .. ما يشاء و يهدي إليه من ينيب وما تطرقوا
+
+426
+00:57:45,830 --> 00:57:58,010
+إلا من بعد ما جاءه من العلمما جاءهم
+
+427
+00:57:58,010 --> 00:58:06,690
+العلم بغيا بينهم ولولا كلمة سبقت من ربك إلى أجر
+
+428
+00:58:06,690 --> 00:58:13,830
+مسمى لقد يبينهم
+
+429
+00:58:16,850 --> 00:58:25,830
+لأخذ يابينهم وإن الذين أورثوا الكتاب
+
+430
+00:58:25,830 --> 00:58:33,770
+من بعدهم لدي شك منهم وليه الله يفتح عليه رأيه يا
+
+431
+00:58:33,770 --> 00:58:36,990
+نور؟
+
+432
+00:58:36,990 --> 00:58:40,230
+أبدا
+
+433
+00:58:40,230 --> 00:58:46,470
+من الشيطان العظيمفلذلك فادعوا واستقموا كما أمرت
+
+434
+00:58:46,470 --> 00:58:54,650
+فلذلك فادعوا واستقموا كما أمرت فلذلك فادعوا
+
+435
+00:58:54,650 --> 00:58:57,030
+واستقموا كما أمرت فلذلك فادعوا واستقموا كما أمرت
+
+436
+00:58:57,030 --> 00:58:57,610
+فلذلك فادعوا واستقموا كما أمرت فلذلك فادعوا
+
+437
+00:58:57,610 --> 00:58:57,910
+واستقموا كما أمرت فلذلك فادعوا واستقموا كما أمرت
+
+438
+00:58:57,910 --> 00:59:04,570
+فلذلك فادعوا واستقموا كما أمرت فلذلك فادعوا
+
+439
+00:59:04,570 --> 00:59:09,650
+واستقموا كما أمرت فلذلك فادعوا
+
+440
+00:59:12,610 --> 00:59:21,350
+لنا أعمالنا ولكم أعمالكم لا حجة بيننا وبينكم الله
+
+441
+00:59:21,350 --> 00:59:29,210
+يجمع بيننا وإلى النصير والذين يحاجون في الله من
+
+442
+00:59:29,210 --> 00:59:37,090
+بعد ما استجيب لوحج من بعد ما استجيب لوحج حجتهم
+
+443
+00:59:37,090 --> 00:59:44,750
+واحدة عند ربهمعند ربهم و عليهم غضب و لهم عذاب و
+
+444
+00:59:44,750 --> 00:59:53,970
+عليهم غضب و لهم .. غضب و لهم عذاب شديد الله الذي
+
+445
+00:59:53,970 --> 01:00:01,610
+أنزل الكتاب بالحق و الميزان و ما أدري قد علم
+
+446
+01:00:01,610 --> 01:00:10,670
+الساعة قريب يستعجل بها الذين لا يؤمنون بهاوالذين
+
+447
+01:00:10,670 --> 01:00:17,850
+آمنوا مش .. مشفقون منها ويعلمون أنها الحق ألا إن
+
+448
+01:00:17,850 --> 01:00:24,330
+الذين .. نبدأ نبدأ نبدأ ألا إن الذين يمار .. ألا
+
+449
+01:00:24,330 --> 01:00:32,410
+إن الذين يمارون في الساعة مافي غلال بعيد غلال بعيد
+
+450
+01:00:32,410 --> 01:00:42,780
+مافي غلال بعيدالله لطيف من عباده يرزق من يشاء و هو
+
+451
+01:00:42,780 --> 01:00:51,260
+القوي العزيز من كان يريد حرث ال .. من كان يريد حرث
+
+452
+01:00:51,260 --> 01:00:59,580
+الآخر فما زده في حرثه و من كان يريدومن كان يريد
+
+453
+01:00:59,580 --> 01:01:07,380
+حرطة الدنيا نبطيه منها وما له في الآخرة من نصيب
+
+454
+01:01:07,380 --> 01:01:13,620
+يقولني حركتين من نصيب؟ من نصيب ما يفتحنا من قراي
+
+455
+01:01:13,620 --> 01:01:24,220
+أسنان أم لهم شرك .. أم لهم شركاء .. أم لهم شركاء
+
+456
+01:01:24,220 --> 01:01:26,700
+شرعوا .. شرعوا .. شرعوا
+
+457
+01:01:29,080 --> 01:01:33,220
+ما لم يأذن
+
+458
+01:01:33,220 --> 01:01:40,070
+بإلهما لم يقدم به الله و لو لا كلمة .. و لو لا
+
+459
+01:01:40,070 --> 01:01:47,530
+كلمة قصد القضية بينهم وإن الظالمين لهم عذاب أليم
+
+460
+01:01:47,530 --> 01:01:52,550
+ترى الظالمين .. ترى الظالمين .. ترى الظالمين مشفق
+
+461
+01:01:52,550 --> 01:01:58,650
+.. مشفقين مما كسبوا هم يعني اللي خلقتهم مما كسبوا
+
+462
+01:01:58,650 --> 01:02:00,710
+و ترى الظالمين ..
+
+463
+01:02:07,040 --> 01:02:13,620
+وهو واقع .. وهو .. وهو واقع بهم والذين آمنوا
+
+464
+01:02:13,620 --> 01:02:19,780
+وعملوا الصالحات في روضات الجنات هم يعملون في روضات
+
+465
+01:02:19,780 --> 01:02:27,220
+الجنات .. في روضات الجنات لهم ما يشاء .. لهم ..
+
+466
+01:02:27,220 --> 01:02:36,770
+لهم ما يشاء .. لهم ما يشاءون عند ربهم .. عند ..عند
+
+467
+01:02:36,770 --> 01:02:43,210
+ربهم ذلك هو ال .. هو الفضل العظيم الكبير ذلك الذي
+
+468
+01:02:43,210 --> 01:02:49,510
+يبشر الله عباده اللذين .. يبشر الله يبشر الله
+
+469
+01:02:49,510 --> 01:02:55,630
+عباده اللذين .. يبشر الله عباده .. يبشر الله
+
+470
+01:02:59,590 --> 01:03:08,850
+عباده الذين آمنوا وعملوا الصالحان قل لا أسألكم
+
+471
+01:03:08,850 --> 01:03:15,770
+عليه أجرا .. أجرا إلا .. أجرا إلاأجراً إلا المو ..
+
+472
+01:03:15,770 --> 01:03:20,650
+إلا المودة .. إلا المودة في القربى إلا المودة ..
+
+473
+01:03:20,650 --> 01:03:27,090
+إلا المودة في القربى ومن يقترب حسنة نزد لهم حسنة
+
+474
+01:03:27,090 --> 01:03:32,610
+نزدهم ومن يقترب حسنة .. ومن .. ومن يقترب .. ومن
+
+475
+01:03:32,610 --> 01:03:38,630
+يقترب حسنة .. حسنة نزدهم فأسات ما يسمعون ومن يقترب
+
+476
+01:03:38,630 --> 01:03:45,370
+حسنة نزدهمومن .. ومن .. ومن يقترف حسنة .. ومن
+
+477
+01:03:45,370 --> 01:03:51,710
+يقترف حسنة نزده .. ومن يقترف حسنة نزده .. فا ..
+
+478
+01:03:51,710 --> 01:03:57,510
+فاكرة يقترف .. يقترف .. طيب .. ومن يقترفو من يقترف
+
+479
+01:03:57,510 --> 01:04:03,490
+حسنة نزد له فيها حسنة بس جيب القسم حسنة نزد له
+
+480
+01:04:03,490 --> 01:04:11,930
+فيها حسنة نزد له فيها حسنة إن الله غفور شكور
+
+481
+01:04:14,770 --> 01:04:24,450
+فإن يشأ الله
+
+482
+01:04:24,450 --> 01:04:31,850
+فإن يشأ الله فإن يشأ الله فإن يشأ الله فإن يشأ
+
+483
+01:04:31,850 --> 01:04:35,070
+الله فإن يشأ الله فإن يشأ الله فإن يشأ الله فإن
+
+484
+01:04:35,070 --> 01:04:41,970
+يشأ الله فإن يشأ الله فإن يشأ الله فإن يشأ الله
+
+485
+01:04:41,970 --> 01:05:08,670
+فإن يشأ الله فإن يشأ اللهيشأ الله يختم
+
+486
+01:05:08,670 --> 01:05:15,240
+على قلبه لأ مش يختمه، يختم علىيختم على .. يختم ..
+
+487
+01:05:15,240 --> 01:05:20,820
+يختم على قلبه ويمحو الله ال .. ويمحو الله الباطل
+
+488
+01:05:20,820 --> 01:05:27,520
+ويحق .. ويحقوا الحق .. ويحقوا الحق بكلماته إنه
+
+489
+01:05:27,520 --> 01:05:34,180
+عليم بذات الصدوة عليم بذات الصدوة و هو .. و هو
+
+490
+01:05:34,180 --> 01:05:38,020
+اللي يقبلته .. و هو .. يقول العظم الهائات .. و هو
+
+491
+01:05:38,020 --> 01:05:43,350
+..وهو اللذي .. وهو اللذي يقبل التوبة عن عباده
+
+492
+01:05:43,350 --> 01:05:49,230
+ويعفو عن .. ويعفو عن السيئات ويعلم ما تفعلوا ..
+
+493
+01:05:49,230 --> 01:05:54,950
+ويعلموا ما تفعلون ويستجيبوا الذين آمنوا وعملوا
+
+494
+01:05:54,950 --> 01:06:01,370
+الصالحات ويزيدهم بالفرد .. ويزيدهم .. ويزيدهم
+
+495
+01:06:12,620 --> 01:06:13,920
+الله يفتح عليه
+
+496
+01:06:17,170 --> 01:06:25,470
+اقرا يا شايمة نعم طيب دي؟ ليش؟ طيب كويس انا خبصت
+
+497
+01:06:25,470 --> 01:06:28,590
+متوتريني شوية بس بس انا كويس مش عارفة ايه خبصت؟
+
+498
+01:06:28,590 --> 01:06:37,990
+انا هراعي نعم خبصت بعدين؟ نعم مش كده يعني
+
+499
+01:06:37,990 --> 01:06:40,970
+الكوركو اغلبته اكتر من المحاضرات العادية بس انا
+
+500
+01:06:40,970 --> 01:06:44,790
+مراعيت التوتر يعني ان شاء الله باخص مشكلة يالا يا
+
+501
+01:06:44,790 --> 01:06:51,830
+شايمةعشان نعيد من عندنا بدأت اسمها أم لهم شركاء و
+
+502
+01:06:51,830 --> 01:06:57,170
+شرعون لآية 21 أعوذ بالله من الشيطان الرجيم باسم
+
+503
+01:06:57,170 --> 01:07:03,590
+الله الرحمن الرحيم أم لهم شركاء و شرعوا لهم من
+
+504
+01:07:03,590 --> 01:07:09,830
+الدين ما لم يألم بالله و لو لا كلمة الفصل لقضية
+
+505
+01:07:09,830 --> 01:07:17,840
+بينهم و إن الظالمين لهم عذاب قليلتروى الذين مشفقين
+
+506
+01:07:17,840 --> 01:07:24,680
+لما كسبوا و هو واقع .. و هو .. و هو واقع بهم و
+
+507
+01:07:24,680 --> 01:07:31,980
+الذين آملوا و عملوا الصالحات في روضات جنات لهم ما
+
+508
+01:07:31,980 --> 01:07:41,920
+يشاءون عند ربهم ذلك هو الفضل الكبيرذلك الذي يبشر
+
+509
+01:07:41,920 --> 01:07:48,980
+الله .. ذلك الذي يبشر الله عباده الذين آمنوا
+
+510
+01:07:48,980 --> 01:07:55,010
+وعملوا الصالحاتقول لا أسألكم عليه أجوا .. أسألكم
+
+511
+01:07:55,010 --> 01:08:02,390
+.. قول لا أسألكم عليه أجوا .. لا أسألكم عليه أجوا
+
+512
+01:08:02,390 --> 01:08:08,790
+إلا المودة في القربة وما يقدر يفحسنة نزد لو فيها
+
+513
+01:08:08,790 --> 01:08:12,050
+.. بتزيد الحكم حركتين اشهرها .. نزد او نزد؟ لأ
+
+514
+01:08:12,050 --> 01:08:21,510
+حسنة نزدةو من يقترب حسنة حسنة نزد له فيها حسنة و
+
+515
+01:08:21,510 --> 01:08:30,710
+من يقترب حسنة حسنة نزد له فيها حسنة إن الله غفور
+
+516
+01:08:30,710 --> 01:08:39,690
+شكوه أم يقولون افتراض على الله كذبه فإيش إلا و
+
+517
+01:08:39,690 --> 01:08:46,290
+يختم على قلبكوينفو الله الباطل ويحق الحق بكلماته،
+
+518
+01:08:46,290 --> 01:08:55,970
+ويحق الحق بكلماته، إنه عليهم وبدات صدوق، وهو الذي
+
+519
+01:08:55,970 --> 01:09:02,030
+يقبل التوبة عن عباده، ويعفو عن السيئات ويعلم ما
+
+520
+01:09:02,030 --> 01:09:08,620
+تفعلونو يستجيب الذين آمنوا و عملوا الصالحات و
+
+521
+01:09:08,620 --> 01:09:16,360
+يزيدهم يثغلهم و الكافرون لهم أعداب شديدة الله يفتح
+
+522
+01:09:16,360 --> 01:09:20,780
+عليك كل ما قرأت هنا اعطيك الله ان شاء الله افتح
+
+523
+01:09:20,780 --> 01:09:21,140
+عليك
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b453f77daf7b4e8f50831f8af3d70951045e227d
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_postprocess.srt
@@ -0,0 +1,1856 @@
+1
+00:00:11,520 --> 00:00:14,340
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:14,340 --> 00:00:18,700
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+3
+00:00:18,700 --> 00:00:22,320
+آله وصحابه وسلم أخدنا يا أخوات في المحاضرة الماضية
+
+4
+00:00:22,320 --> 00:00:27,620
+المخارج وبين أن هناك مخارج عامة ومخارج خاصة أخدنا
+
+5
+00:00:27,620 --> 00:00:31,360
+المخارج العامة اللي هو الجوفوالحلق، اللسان،
+
+6
+00:00:31,360 --> 00:00:35,460
+الشفتان، الخشوم، ثم أخدنا بعد ذلك ما ينبثق عن هذه
+
+7
+00:00:35,460 --> 00:00:39,360
+المخارج عامة من المخارج الخاصة سبعة عشر مخرجا
+
+8
+00:00:39,360 --> 00:00:44,180
+فرعيا و اليوم إن شاء الله بناخد أيضا الصفات و هو
+
+9
+00:00:44,180 --> 00:00:47,920
+الشطر الثاني من هذا الموضوع الذي هو المخارج
+
+10
+00:00:47,920 --> 00:00:52,480
+والصفات أما بالنسبة للصفات يا أخوات فهو جمع صفة
+
+11
+00:00:53,120 --> 00:00:58,320
+والصفة معناتها من حيث اللغة هو ما قام بالشيء من
+
+12
+00:00:58,320 --> 00:01:03,020
+المعاني حسيا كان كالبياضي والسوادي أو معنويا
+
+13
+00:01:03,020 --> 00:01:07,680
+كالكرمي والشجاعة والعلمي والجهل ونحو ذلك يعني هذا
+
+14
+00:01:07,680 --> 00:01:11,470
+من حيث اللغةيعني ما أقوم بالشيء من المعنى نقوله
+
+15
+00:01:11,470 --> 00:01:18,050
+هذا أبيض أسود طويل قصير هذا حسي أو معنوي نقول مثلا
+
+16
+00:01:18,050 --> 00:01:25,470
+كريم شجاع ذكي غبي متعلم جاهل و هكذا هذا من حياته
+
+17
+00:01:25,470 --> 00:01:30,510
+اللغة أما من حياته الإصطلاح فالصفة هي كيفية تثبت
+
+18
+00:01:30,510 --> 00:01:37,350
+للحرف عند النطق به فيتميزه عن غيره من الأحرفكيفية
+
+19
+00:01:37,350 --> 00:01:43,550
+تثبت؟ يعني مثلا في عندنا الغنى، في عندنا الشدة،
+
+20
+00:01:43,550 --> 00:01:48,450
+الجهر، الخفاء وغير ذلك من الصفات أما بالنسبة
+
+21
+00:01:48,450 --> 00:01:52,410
+للفائدة من تعريفنا للصفات، يعني ما الفائدة التي
+
+22
+00:01:52,410 --> 00:01:58,130
+يمكن أن نجدها عندما نتعرف أو ندرس موضوع الصفات أو
+
+23
+00:01:58,130 --> 00:02:05,130
+فوائد معرفة الصفات، ما هي أخوات؟ فضليأول شي تمييز
+
+24
+00:02:05,130 --> 00:02:09,560
+الحروف المشتركة في المخرجيعني كل مخرج له حروف
+
+25
+00:02:09,560 --> 00:02:13,680
+معينة بعض المخرج بتخرج صفة او حرف واحد وبعض المخرج
+
+26
+00:02:13,680 --> 00:02:18,520
+تخرج تلت صفات او اكثر او اقل عندنا مثلا مخرج حرف
+
+27
+00:02:18,520 --> 00:02:23,720
+ال ميم والباب ام اب كلا هما يخرجوا عند انطباق
+
+28
+00:02:23,720 --> 00:02:28,920
+الشفتين لكن صفة ال ميم تختلف عن صفة الباب صفة
+
+29
+00:02:28,920 --> 00:02:34,860
+الباب عند انطباق الشفتين بتخرج القلق نقول ابوصفة
+
+30
+00:02:34,860 --> 00:02:39,580
+الـ Meme برضه عند انطباق الشفتين ولكنها بتخرج منها
+
+31
+00:02:39,580 --> 00:02:46,000
+صفة الغنى إذا من ضمن ثوائد معرفتنا للصفات اللي هو
+
+32
+00:02:46,000 --> 00:02:49,560
+تمييز الحروف المشتركة في المخرج فلو لا الصفات لمّا
+
+33
+00:02:49,560 --> 00:02:53,580
+سطعنا أن نتعرف على هذه الحروف مع أن مخرج ال ميم
+
+34
+00:02:53,580 --> 00:02:58,160
+والبا مخرجهم واحد إلا أن صفة البا قلقلق وصفة ال
+
+35
+00:02:58,160 --> 00:03:02,360
+ميم غنى فالميم فيها غنى من تمييزنا عن حرف البا
+
+36
+00:03:02,360 --> 00:03:10,640
+كذلك ال itوالاط و الاد الاط فيها قلقلة والاد فيها
+
+37
+00:03:10,640 --> 00:03:16,160
+همس فالاد تختلف عن الأط لذلك الصفات يستطيعون من
+
+38
+00:03:16,160 --> 00:03:20,320
+خلالها تمييز الحروف المشتركة في المخرج الواحد
+
+39
+00:03:20,320 --> 00:03:26,270
+الفايدة الثانية يا أخوان هي فضل أختمعرفة الحروف
+
+40
+00:03:26,270 --> 00:03:29,630
+القوية من الحروف الضعيفة طبعا نحن ان شاء الله سوف
+
+41
+00:03:29,630 --> 00:03:33,750
+ناخد من خلال دراستنا للصفات أن هناك صفات قوية
+
+42
+00:03:33,750 --> 00:03:39,650
+وصفات ضعف مثلا في عندنا صفة الهمس صفات ضعف ضدها
+
+43
+00:03:39,650 --> 00:03:44,870
+الجهر صفات قوة في عندنا الشدة صفات قوة ضدها
+
+44
+00:03:44,870 --> 00:03:49,970
+الرقابة صفات ضعف الاستعلاء صفات قوة ضدها الاستفاد
+
+45
+00:03:49,970 --> 00:03:54,490
+صفات ضعف و هكذا إذا الصفات التي سوف ندرسها فيها
+
+46
+00:03:54,490 --> 00:04:00,020
+صفات قوةوصفات ضعف لذلك يعني نستطيع أن نتعرف على
+
+47
+00:04:00,020 --> 00:04:03,940
+الحروف القوية من الحروف الضعيفة من خلال تعريفنا
+
+48
+00:04:03,940 --> 00:04:07,840
+على الصفات طب ماذا نستفيد عندما نعرف أن هذا الحرف
+
+49
+00:04:07,840 --> 00:04:11,860
+قوي ولا هذا الحرف ضعيف؟ ماذا يمكن أن نستفيد يا
+
+50
+00:04:11,860 --> 00:04:19,300
+أخوات؟ فضليصحيح نستطيع أن نعرف الحرف الذي يضغم في
+
+51
+00:04:19,300 --> 00:04:23,800
+غيره أو الحرف الذي لا يضغم في الذي يليه إذا كان
+
+52
+00:04:23,800 --> 00:04:28,860
+الحرف الضعيف الضعيف بيضغم في القوي لكن القوي لا
+
+53
+00:04:28,860 --> 00:04:35,310
+يضغم في الضعيف مثال ذلك هنافأمن الطائفة الطا هنا
+
+54
+00:04:35,310 --> 00:04:42,150
+صفتها ضعيفة والأط صفات طوة فالطا بتضغم في الطا لأن
+
+55
+00:04:42,150 --> 00:04:47,010
+الطا ضعيفة بتضغم في الطا القوية مثال و ذلك لو في
+
+56
+00:04:47,010 --> 00:04:53,350
+عندنا إناء واسع وإناء صغير الإناء الصغير يضغم أو
+
+57
+00:04:53,350 --> 00:04:57,910
+يدخل في الإناء الواسع لكن الإناء الواسع لا يدخل في
+
+58
+00:04:57,910 --> 00:05:03,690
+الإناء الضيقهنا مثلا في أمن الطائفة التى دخلت
+
+59
+00:05:03,690 --> 00:05:10,210
+فالطى مباشرة بينما في عندما نقرأ كلمة أحتو الطى
+
+60
+00:05:10,210 --> 00:05:17,110
+صفت قوة والتى صفت ضعف فلنقول أحتو لا تضغم الطى
+
+61
+00:05:17,110 --> 00:05:23,210
+بالتى لأن الطى لو أضغمت بالتى تقرأ أحتو لكنها ليست
+
+62
+00:05:23,210 --> 00:05:30,140
+أحتو هي أحتو يعني تظهر الطى أحتوتو الطار تظهر و
+
+63
+00:05:30,140 --> 00:05:34,300
+الطا وبالتالي لا تضغم في هذه الإضغامة كاملا بينما
+
+64
+00:05:34,300 --> 00:05:40,380
+في أمنات طائفة الطا تدخل كلها ذاتها وصفاتها في حرف
+
+65
+00:05:40,380 --> 00:05:43,600
+الطا وبالتالي ممكن نسميه إضغام وأما بالنسبالي اللي
+
+66
+00:05:43,600 --> 00:05:47,740
+أحطته فلا يوجد إضغام كامل ماشي هذه الفائدة الثانية
+
+67
+00:05:47,740 --> 00:05:49,940
+الفائدة الثالثة يا بنات فضلي
+
+68
+00:05:52,800 --> 00:05:56,240
+من فوائد معرفتنا يا أخوات للصفات أيضا تحسين النطق
+
+69
+00:05:56,240 --> 00:06:02,660
+بالحروف المختلفة في المخارج مثلا عندنا الath والis
+
+70
+00:06:03,370 --> 00:06:10,210
+ازاي ال is نقول is و ال .. و ال if نقول if ذلك
+
+71
+00:06:10,210 --> 00:06:15,950
+الكتاب مثلا الذين الذي .. لكن لا نقول الذين و الذي
+
+72
+00:06:15,950 --> 00:06:21,430
+و ذلك لأن هذا حرف يعني له مخرج غير عن الحرف الثاني
+
+73
+00:06:21,430 --> 00:06:27,100
+كذلك عندما نقول الحقفالقهف هنا فيها قلقلة أو
+
+74
+00:06:27,100 --> 00:06:32,600
+مقتدرة مقتدرة أيضا فيها قلقلة ولكنها قلقلة صغيرة
+
+75
+00:06:32,600 --> 00:06:37,660
+في عندنا مثلا تبت يد أبي لهبي و تب ال ب فيها قلقلة
+
+76
+00:06:37,660 --> 00:06:44,540
+أو مثلا في عندنا صفات الهمس مثال ذلك ال itقالت فتة
+
+77
+00:06:44,540 --> 00:06:48,820
+فيها همس أو فيها قلقلة أو فيها و هكذا يعني نستطيع
+
+78
+00:06:48,820 --> 00:06:52,700
+أن نحسم النطق بالحروف المختلفة في المخرج الواحد
+
+79
+00:06:52,700 --> 00:06:56,980
+إذا فائدة معرفتنا للصفات تلاتة تمييز الحروف
+
+80
+00:06:56,980 --> 00:07:00,200
+المشتركة في المخرج الواحد فلو للصفات لمّا استطعنا
+
+81
+00:07:00,200 --> 00:07:03,770
+أن نميز ما بينهاالحروف التي مخرجها واحد مثل حرف
+
+82
+00:07:03,770 --> 00:07:07,170
+البا وحرف ال ميم، اتنين معرفة الحروف القوية من
+
+83
+00:07:07,170 --> 00:07:11,370
+الحروف الضعيفة اذ ان الصفات فيها صفات قوة وصفات
+
+84
+00:07:11,370 --> 00:07:15,210
+ضعف فنعرف ان هذا الحرف ضعيف و هذا الحرف قوي من
+
+85
+00:07:15,210 --> 00:07:19,710
+كثرة الصفات الضعيفة او القويةونستفيد من هذا الأمر
+
+86
+00:07:19,710 --> 00:07:24,270
+معرفة الحرف الذي يضغم من الحرف الذي لا يضغم الحرف
+
+87
+00:07:24,270 --> 00:07:27,890
+الضعيف يضغمه في الحرف القوي لكن الحرف القوي لا
+
+88
+00:07:27,890 --> 00:07:31,210
+يضغمه في الحرف الضعيف رقم تلاتة تحسين النطق
+
+89
+00:07:31,210 --> 00:07:36,290
+بالحروف المختلفة في المخرج الواحد كذلك يا أخوات
+
+90
+00:07:36,290 --> 00:07:43,130
+تنقسم صفات الحروف إلى قسمين صفات ذاتية وصفات عرضية
+
+91
+00:07:44,350 --> 00:07:47,210
+الصفات الذاتية يا أخوات هي الصفات المنازمة للحرف و
+
+92
+00:07:47,210 --> 00:07:51,750
+التي لا تنفك عنه بأي حال من الأحوال صفات ذاتية
+
+93
+00:07:51,750 --> 00:07:57,250
+يعني ملسقة و ملزمة بالحرف لا تنفك عنه مثل القلقلة
+
+94
+00:07:57,250 --> 00:08:02,970
+والجهرالقلقلة صفة ذاتية والجهر صفة ذاتية والشدة
+
+95
+00:08:02,970 --> 00:08:07,390
+والرخابة والهمس كل صفات ذاتية وهي الصفات التي سوف
+
+96
+00:08:07,390 --> 00:08:11,430
+ندرسها لا تنفك عن أي حرف من هذه الحروف بأي حالة من
+
+97
+00:08:11,430 --> 00:08:14,510
+الأحوال سواء كان جاء الحرف لوحده ولا جاء في وسط
+
+98
+00:08:14,510 --> 00:08:18,230
+الكلمة ولا جاء في نهاية الكلمة نأتي بالمثال مثلا
+
+99
+00:08:18,230 --> 00:08:26,710
+عندما نقول مثلا الحق القلقلة ظهرت الحقو لو جينا به
+
+100
+00:08:26,710 --> 00:08:33,470
+لوحده نقول اق برضه ملزم في الحرف كذلك لو جينا بوصل
+
+101
+00:08:33,470 --> 00:08:38,650
+الكلمة نقول مقتدرا القاف أيضا تقلقل ولكنها قلقلة
+
+102
+00:08:38,650 --> 00:08:43,690
+صغيرة و كذلك أي صفة من هذه الصفات و كذلك صفة الجهر
+
+103
+00:08:43,690 --> 00:08:47,730
+والشدة والاستعلاء وغير ذلك من الصفات التي سوف
+
+104
+00:08:47,730 --> 00:08:52,600
+ندرسها و كلها صفات ذاتيةأما الصفات العرضية وهي
+
+105
+00:08:52,600 --> 00:08:57,100
+الصفات التي يتصف بها الحرف أحيانا ويفارقه أحيانا،
+
+106
+00:08:57,100 --> 00:09:00,840
+يعني .. يعني تلازم الحرف في حالات وتفارقه في
+
+107
+00:09:00,840 --> 00:09:05,440
+حالات، يعني نعرف حسب موقعه، مثلا التفخيم والترقيد
+
+108
+00:09:06,840 --> 00:09:11,900
+حسب يعني فخم مثلا زي الألف مثلا تفخم الألف أو تفخم
+
+109
+00:09:11,900 --> 00:09:14,860
+اللام في لفظ الجلالة أو الرا انشوف مثلا اللام في
+
+110
+00:09:14,860 --> 00:09:18,720
+لفظ الجلالة متى تفخم اللام في لفظ الجلالة لو كان
+
+111
+00:09:18,720 --> 00:09:23,920
+ما قبلها مفتوح أو مضمون من يأتي بمثال فيه تفخيم
+
+112
+00:09:23,920 --> 00:09:25,480
+اللام في لفظ الجلالة؟
+
+113
+00:09:30,050 --> 00:09:36,350
+صحيح ألف لاميم الله لا إله ولا حي القيوم لأ شيء ..
+
+114
+00:09:36,350 --> 00:09:43,150
+شيء ثاني إن الله .. إن الله أسهر في لفظ الجلالة
+
+115
+00:09:43,150 --> 00:09:50,190
+قلنا الله بينفع نقول إن اللهلأ إن الله وملائكته أو
+
+116
+00:09:50,190 --> 00:09:57,410
+رسول الله ناقة الله كتاب الله اللام تفخم لأنها
+
+117
+00:09:57,410 --> 00:10:03,950
+مسبقة بفتح إن الله أو بضم رسول الله لكنها ترقق إذا
+
+118
+00:10:03,950 --> 00:10:08,130
+سبقها حرف مكسور من يأتي بمثال ترقق فيه اللام
+
+119
+00:10:08,130 --> 00:10:13,090
+تفضليهبسم الله الرحمن الرحيم لما قول بسم الله
+
+120
+00:10:13,090 --> 00:10:17,350
+الرحمن الرحيم لأن اللام في لفظ الجلالة إذا سبقها
+
+121
+00:10:17,350 --> 00:10:22,710
+مكسور ترقق وإذا سبقها مفتوح أو مضموم تفخم فالتفخيم
+
+122
+00:10:22,710 --> 00:10:28,390
+والترقيق صفات عرضية كذلك في عندنا الألف الألف تفخم
+
+123
+00:10:28,390 --> 00:10:31,890
+أيضا في حالات و ترقق في حالات ماذا تفخم الألف ..
+
+124
+00:10:31,890 --> 00:10:38,470
+فضل أختحسب ما قبلها إن كان ما قبلها مفخما فخمة مثل
+
+125
+00:10:38,470 --> 00:10:42,870
+الطامة
+
+126
+00:10:42,870 --> 00:10:46,850
+ولا الضالين
+
+127
+00:10:46,850 --> 00:10:51,290
+حرف الضاد حرف استعلاء اللي بعده مدام اللي ما سبق
+
+128
+00:10:51,290 --> 00:10:57,090
+الألف مفخم إذا الألف تفخم وإذا سبقها مراقق تراقع
+
+129
+00:10:57,090 --> 00:11:03,420
+منهيت بمثالالسائلين، السائلين، ما بنقولش الصائلين
+
+130
+00:11:03,420 --> 00:11:09,380
+أو النار، ما بنقولش النار، النار، النون مراققة،
+
+131
+00:11:09,380 --> 00:11:13,820
+إذا نقلف اللي بعدها مراققة كذلك الرأ أيضا تفخم في
+
+132
+00:11:13,820 --> 00:11:17,820
+حالات و ترقق في حالات تفخم الرأ لو كانت مضمومة أو
+
+133
+00:11:17,820 --> 00:11:24,380
+مفتوحة، نقول رأةرؤيا الرأى مفخر نقول نملأ بها الفم
+
+134
+00:11:24,380 --> 00:11:30,340
+لكن عندما تكون مكسورة ترقق نقول بريحن بريحن ا
+
+135
+00:11:30,340 --> 00:11:35,080
+فرعون فرعون يعني الرأى دول بتكون ظاهرة لأنها بتكون
+
+136
+00:11:35,080 --> 00:11:40,550
+مرققةإذا صفات ذاتية وصفات عرضية الصفات الذاتية هي
+
+137
+00:11:40,550 --> 00:11:44,250
+الصفات التي تلازم الحرف بكل أحواله ولا تفارقه بأي
+
+138
+00:11:44,250 --> 00:11:48,110
+حالة من الأحوال مثل الشدة والجهر والرخاء
+
+139
+00:11:48,110 --> 00:11:51,470
+والاستعلاء والاستفال والاطباق والإذلاق الصفات التي
+
+140
+00:11:51,470 --> 00:11:55,070
+سوف ناخدهاأما الصفات العرضية هي صفات قليلة وهي
+
+141
+00:11:55,070 --> 00:11:58,690
+صفات التفخيم والتعقيد تفخن بعض الحروف في حلات
+
+142
+00:11:58,690 --> 00:12:03,010
+وترقق في حلات ومعنى الصفات العرضية هي الصفات التي
+
+143
+00:12:03,010 --> 00:12:06,990
+تلازم الحرف في حلات وتفارقهم في حلات الصفات التي
+
+144
+00:12:06,990 --> 00:12:12,450
+سوف ندرسها يا أخوات هي ايه الصفات الذاتية الصفات
+
+145
+00:12:12,450 --> 00:12:17,730
+الذاتية الملازمة للحرف وهي كم صفة؟عشرون صفة سوف
+
+146
+00:12:17,730 --> 00:12:22,490
+ندرسها بعض العلماء قال له لأ هي تمانتاشر صفة لكن
+
+147
+00:12:22,490 --> 00:12:30,710
+يضاف عليها صفة الخفاء والغنى صارت عشرين أما
+
+148
+00:12:30,710 --> 00:12:33,110
+بالنسبة للصفات اللتي سوف ندرسها ان شاء الله اللي
+
+149
+00:12:33,110 --> 00:12:38,330
+هي العشرون صفة في عندنا صفات متضادةيعني لها ضد
+
+150
+00:12:38,330 --> 00:12:42,170
+وصفات ليس لها ضد الصفات المتضادة إيش يا أخوات؟
+
+151
+00:12:42,170 --> 00:12:46,630
+يعني الصفة وضدها وعكسها وهذه الصفات المتضادة
+
+152
+00:12:46,630 --> 00:12:50,230
+تتقاسم حروف اللغة العربية يعني حروف اللغة العربية
+
+153
+00:12:50,230 --> 00:12:53,050
+تمانية وعشرين حرف أو واحد و تلاتين حرف بالنسبة لو
+
+154
+00:12:53,050 --> 00:12:57,890
+أضافنا لها الحروف المد تتقاسمها يأمل تكون كذا إذا
+
+155
+00:12:57,890 --> 00:13:01,690
+لم تكن في الشدة كانت في الرخاء وإذا لم تكن في
+
+156
+00:13:01,690 --> 00:13:05,550
+الهمس بتكون في الجهر و هكذاإذا في عندنا صفات
+
+157
+00:13:05,550 --> 00:13:11,770
+متضادة و هي الهمسو أو الجهرق و ضده الهمس الشدة و
+
+158
+00:13:11,770 --> 00:13:15,490
+ضدها الرخاوة و بينها هو التوسط الاستعلاء و ضده
+
+159
+00:13:15,490 --> 00:13:20,150
+الاستفال الإطباق و ضده الانفتاح الإذلاق و ضده
+
+160
+00:13:20,150 --> 00:13:25,370
+الإصباط كام صفة صرنا ماخدين؟11 صفة يعني خمس صفات
+
+161
+00:13:25,370 --> 00:13:30,110
+متضهضة وفي عندنا التوسط صفة رقم 11 وفي عندنا صفات
+
+162
+00:13:30,110 --> 00:13:34,730
+أخوات ليست لها ضد يعني صفة لوحدها لها حروف معينة
+
+163
+00:13:34,730 --> 00:13:38,890
+هذه الصفات اللتي ليست لها ضد ان هي الصفير والقلقلة
+
+164
+00:13:38,890 --> 00:13:44,890
+واللين والانحراف والتكرير والتفشي والاسطالة والغنى
+
+165
+00:13:44,890 --> 00:13:48,790
+والغفاء مجموعة هذه الصفات اللتي سوف ندرسها كام صفة
+
+166
+00:13:48,790 --> 00:13:54,520
+يا أخوات؟هي تسعى بصفات يعني ليست لها ضد ومع الصفات
+
+167
+00:13:54,520 --> 00:14:00,020
+اللي متضادة عشرون صفة نبدأ الآن بالشرح التفصيلي
+
+168
+00:14:00,020 --> 00:14:04,980
+لهذه الصفات أول صفة عندنا يا أخوات ما هي صفة الهمس
+
+169
+00:14:04,980 --> 00:14:10,500
+ما معنى الهمس يعني واحد يهمس همسا يعني يتكلم كلام
+
+170
+00:14:10,500 --> 00:14:16,920
+خافي إذا الهمس لغة الخفاء وفي الإصطلاح من يعرف أن
+
+171
+00:14:16,920 --> 00:14:17,620
+أنا الهمس تفضلي
+
+172
+00:14:22,790 --> 00:14:27,930
+أحسنتي جريان النفس في المخرج عند النطق بحرف الهمس
+
+173
+00:14:27,930 --> 00:14:32,570
+لضعف اعتماد الحرف على مخرجه يعني الأثناء النطق
+
+174
+00:14:32,570 --> 00:14:37,610
+بالحرف نجد أن ال .. ال .. الريح أو النفس يجري نقول
+
+175
+00:14:37,610 --> 00:14:43,230
+مثلا ها اف .. اف .. اف .. في ريح ولا مافي ريح؟ في
+
+176
+00:14:43,230 --> 00:14:50,410
+نفس كذلك غير عن ال اب .. اب في نفس ال اط .. اط ..
+
+177
+00:14:50,410 --> 00:14:54,120
+فاش نفس ال اط .. اط ..لا يوجد .. لا يوجد نفس، لكن
+
+178
+00:14:54,120 --> 00:15:01,620
+ال .. ال .. اللي هي حروفه حثه شخص فسكت، يعني عشر
+
+179
+00:15:01,620 --> 00:15:07,060
+حروف، حثه شخص فسكت، عشر حروف، هذه حروف نسميها حروف
+
+180
+00:15:07,060 --> 00:15:12,600
+الهمس، إذا من يعرف لنا الهمس؟ هو؟ فضليه؟ هو جريان
+
+181
+00:15:12,600 --> 00:15:15,280
+النفس في المخرج عند نطق حرف الهمس لضعف اعتماد
+
+182
+00:15:15,280 --> 00:15:20,630
+الحرف على مخرجه وما هو .. وما هي حروفه؟ فضليه؟حتى
+
+183
+00:15:20,630 --> 00:15:26,590
+وشخص فسكت كام حرف عشرة حروف كام بقية من الحروف
+
+184
+00:15:26,590 --> 00:15:31,210
+باقية حروف اللغة العربية اللي هي ماتسمت بحروف إيش
+
+185
+00:15:31,210 --> 00:15:36,210
+بحروف الجهر وهي واحد وعشرين حرف لو اعتبرنا أن حروف
+
+186
+00:15:36,210 --> 00:15:40,490
+اللغة العربية واحد وتلاتين حرف عشرة حروف الهمس حتى
+
+187
+00:15:40,490 --> 00:15:43,650
+وشخص فسكت باقي الحروف اللي هي واحد وعشرين حرف
+
+188
+00:15:43,650 --> 00:15:51,700
+نسميها حروف إيش حروف الجهر والجهر لغة إيهالظهور
+
+189
+00:15:51,700 --> 00:15:55,960
+والإعلان، جهرية الدعوة، يعني أو جهرة بالدعوة بمعنى
+
+190
+00:15:55,960 --> 00:16:01,020
+أظهرها، أظهرت الشيء بمعنى أعلنته وبينته، إذا الجهر
+
+191
+00:16:01,020 --> 00:16:05,840
+هو الظهور والإعلان وفي الإصطلاح، ما هو تعريفه في
+
+192
+00:16:05,840 --> 00:16:09,420
+الإصطلاح؟ فضل أختي هي انحفاز النفس في المغرج عند
+
+193
+00:16:09,420 --> 00:16:15,990
+نطق بحرف الجهرأحسنتِ إذا هناك قلنا في الهمس جريان
+
+194
+00:16:15,990 --> 00:16:20,970
+النفس في المخرج عند النطق بحرف الهمس لضعف اعتماد
+
+195
+00:16:20,970 --> 00:16:26,630
+الحرف على مخرجه هنا عكسه إن انحباس النفس في المخرج
+
+196
+00:16:26,630 --> 00:16:31,170
+عند النطق بحرف الجهر لقوة اعتماد الحرف على مخرجه
+
+197
+00:16:31,170 --> 00:16:36,610
+عندما ننطق بحرف الجهر نجد أن النفس يحبس مثل مثال
+
+198
+00:16:36,610 --> 00:16:46,920
+ذلكانحبس النفس، كويس؟ إب إد طط اطط اج مناجد أن
+
+199
+00:16:46,920 --> 00:16:51,140
+النفس يحبس في هذه الحروف إذا انحباس النفس في
+
+200
+00:16:51,140 --> 00:16:55,940
+المخرج عند النط بحرف الجهر لقوة اعتماد الحرف على
+
+201
+00:16:55,940 --> 00:17:01,260
+مخرجه وحروف الجهر ما هي؟باقي حروف اللغة العربية او
+
+202
+00:17:01,260 --> 00:17:07,260
+نقول المجموعة في قوله ايش عظمة وزنقارق غضن ذي طلب
+
+203
+00:17:07,260 --> 00:17:13,600
+جد ما معناه يا أخوات عظمة وزنقارق غضن ذي طلب جد هل
+
+204
+00:17:13,600 --> 00:17:19,170
+المراد معرفة الجملة تكون لها معنىيعني الغرب من
+
+205
+00:17:19,170 --> 00:17:23,310
+إيجاد مثل هذه الكلمات مثل كلمة أخي هاكا علما حازا
+
+206
+00:17:23,310 --> 00:17:29,070
+وغيره خاسره يرملون ينمو كذلك اللي هي عظمه وازنقار
+
+207
+00:17:29,070 --> 00:17:33,210
+انغضن ذي طلب جد حثه وشخص فسكت هذه كلها عبارة عن
+
+208
+00:17:33,210 --> 00:17:38,480
+محاولة لجمع الحروف المطلوبة في جملةأو في بيت شعير
+
+209
+00:17:38,480 --> 00:17:44,820
+أو في كلمة حتى يسهل علينا حفظها لذلك أنا أقول هي
+
+210
+00:17:44,820 --> 00:17:50,160
+غير مطلوب المعنى لكن ممكن أن يكون لها معنى ما هو
+
+211
+00:17:50,160 --> 00:17:57,280
+معناها عظمة وزن قارئ غضل ذي طلب جد؟يعني عظمة منزلة
+
+212
+00:17:57,280 --> 00:18:01,880
+القارئ الغضب ما معنى القارئ الغضب الصغير ذي طلب جد
+
+213
+00:18:01,880 --> 00:18:07,380
+الذي يجتهد في طلب العلم عظمة وزن قارئ غضب ذي طلب
+
+214
+00:18:07,380 --> 00:18:12,100
+جد عظمة منزلة القارئ الصغير ذي طلب جد يعني لو كان
+
+215
+00:18:12,100 --> 00:18:18,060
+مثلا عندنا ولد صغير حافظ القرآن وشيخ كبير غير حافظ
+
+216
+00:18:18,060 --> 00:18:24,160
+شيء من القرآن وارد أن نوقف إمامامن سيقف أمام يأمر
+
+217
+00:18:24,160 --> 00:18:29,200
+القوم أقراهم لكتاب الهافظ، إذا عظم منزلة هذا الولد
+
+218
+00:18:29,200 --> 00:18:33,820
+الصغير الغد لأنه يحفظ القرآن، إذا عظم وزن قارئ غد
+
+219
+00:18:33,820 --> 00:18:40,360
+ذي طلب جد، هذا بالنسبة للجهروحروفه واحد وعشرين حرف
+
+220
+00:18:40,360 --> 00:18:44,640
+الآن صفة الجهر يا أخوات وكمان صفة الهمس كلاهما
+
+221
+00:18:44,640 --> 00:18:49,740
+بتثبتوا للحرف في حالة العركة أو السكون واصلا ووقفا
+
+222
+00:18:49,740 --> 00:18:55,460
+يعني في كل أحواله لو جينا بالحرف ساكن مثل البروج
+
+223
+00:18:55,460 --> 00:19:02,620
+فيه إيش يعني جهر انفطرت فيه همس مثلا يعني بحيث لو
+
+224
+00:19:02,620 --> 00:19:09,670
+كانت الحرفالهمس أو الجهر ساكن أو متحرك موقوف عليه
+
+225
+00:19:09,670 --> 00:19:13,790
+أو موصول بتظهر عليه صفة الجهر أو بتظهر عليه صفة
+
+226
+00:19:13,790 --> 00:19:18,270
+الهمس لو كان هو من حروف الهمس صفة الهمس يا أخوات
+
+227
+00:19:18,270 --> 00:19:24,890
+هل هي صفة قوة ولا صفة ضعف؟الهمس صفة ضاف أما الجهر
+
+228
+00:19:24,890 --> 00:19:31,010
+ضدها صفة قوة وصفة الهمس والجهر صفتان متضادتان
+
+229
+00:19:31,010 --> 00:19:35,910
+وكلاهما تتنازعان حروف اللغة العربية يعني بتتقاسم
+
+230
+00:19:35,910 --> 00:19:40,590
+حروف اللغة العربية هل يمكن أن يكون الحرف موجود في
+
+231
+00:19:40,590 --> 00:19:45,240
+الهمس وفي نفس الوجد موجود في الجهر؟لأ إما أن يكون
+
+232
+00:19:45,240 --> 00:19:49,920
+الحرف في همس وإما أن يكون في الجهر لذلك نقول أن
+
+233
+00:19:49,920 --> 00:19:55,120
+حروف الهمس حثه شخص فسكت وحروف الجهر باقي حروف
+
+234
+00:19:55,120 --> 00:19:59,360
+اللغة العربية ولا يمكن أن يكون الحرف فيه صفة الهمس
+
+235
+00:19:59,360 --> 00:20:05,460
+وصفة الضعف ولكن كل حرف أقل شيء هيكون فيه خمس صفات
+
+236
+00:20:05,460 --> 00:20:10,740
+هنا عندنا كام صفة يا بنات؟عشرون صفة كل حرف من حروف
+
+237
+00:20:10,740 --> 00:20:13,820
+أقل شيء هيكون فيه خمس صفات اللي هي الخمس صفات
+
+238
+00:20:13,820 --> 00:20:18,340
+المتضاعفة أقل شيء لكن ممكن يكون فيه ست صفات وممكن
+
+239
+00:20:18,340 --> 00:20:24,440
+يكون سبع صفات مع بعضها البعض ونستطيع أن نميز ما
+
+240
+00:20:24,440 --> 00:20:29,600
+بين الحرف القوي والضعيف من وجود الصفات القوة أو
+
+241
+00:20:29,600 --> 00:20:34,300
+الصفات الضعف في هذا الحرفخلصنا يا أخوات الصفة
+
+242
+00:20:34,300 --> 00:20:40,180
+الأولى المتضادة و ضدها همس و ضده الجهر الهمس صفة
+
+243
+00:20:40,180 --> 00:20:44,800
+ضعف الجهر صفات قوة الهمس حروفه حتى و شخص فسكت
+
+244
+00:20:44,800 --> 00:20:49,360
+الجهر باقي حروف اللغة العربية أو أن نقول هي حروف
+
+245
+00:20:49,360 --> 00:20:54,020
+عظمة و نقارن غضن دي طالب جد الصفات الصفات الهمس و
+
+246
+00:20:54,020 --> 00:20:57,280
+الجهر ممكن تكون ملازمة للحرف في حد السكون عندما
+
+247
+00:20:57,280 --> 00:21:02,220
+يكون ساكن أو متحرك ولكن يكون يعني أقل أو في وسط
+
+248
+00:21:02,220 --> 00:21:08,140
+الكلمةيعني موصول أو موقوف عليهم الصفة الثانية يا
+
+249
+00:21:08,140 --> 00:21:13,440
+أخوات اللي هي صفة الشدة و ضدها الرخاوة و بين الشدة
+
+250
+00:21:13,440 --> 00:21:19,190
+والرخاوة التوسط ما معنى الشدة يا أخوات؟فلان شديد
+
+251
+00:21:19,190 --> 00:21:23,810
+يعني إيه؟ قوة والحرف الشديد يعني قوة والشدة في
+
+252
+00:21:23,810 --> 00:21:28,910
+الإصطلاح انحباس الصوت في المخرج عند النطق بحرف
+
+253
+00:21:28,910 --> 00:21:33,010
+الشدة لقوة اعتماد الحرفي على مخرجه يعني بيشبه
+
+254
+00:21:33,010 --> 00:21:38,290
+تماما اللي هو الهمس والجهر يعني بيشبه الجهر هناك
+
+255
+00:21:38,290 --> 00:21:45,060
+بيقول انحباس النفسفي المخرج هنا نقول انحباس الصوت
+
+256
+00:21:45,060 --> 00:21:50,020
+في المخرج عند النطق بحرف الشدة ليش لقوة اعتماد
+
+257
+00:21:50,020 --> 00:21:53,700
+الحرف على المخرج اما نجد ان الحرف يعتمد اعتماد
+
+258
+00:21:53,700 --> 00:21:59,460
+كامل على المخرج انا عندما اقول مثلا لا يعتمد لان
+
+259
+00:21:59,460 --> 00:22:04,760
+في نفس بيجري و في نريح بمشي لكن عندما اقول اب
+
+260
+00:22:08,150 --> 00:22:13,430
+المخرج بيعتمد وبيلتزق الاتصالات لدرجة أنه يمنع
+
+261
+00:22:13,430 --> 00:22:18,710
+جريان النفس وجريان الصوت لا في صوت ولا في نفس فإذا
+
+262
+00:22:18,710 --> 00:22:22,470
+فتح المخرج ايب تخرج معاه نبرة ومن سميها القلقلة
+
+263
+00:22:22,470 --> 00:22:27,710
+عندما أقول ابانحبس النفس وانحبس المخرج وممكن يا
+
+264
+00:22:27,710 --> 00:22:32,570
+أخوات اللي هو الحرف فيه صفة الهمس وصفة الرخاوة أو
+
+265
+00:22:32,570 --> 00:22:36,390
+فيه صفات متضادة لأنه قلنا أن أقل شيء في الحرف لابد
+
+266
+00:22:36,390 --> 00:22:42,430
+أن يكون فيه خمس صفات عرفنا صفة الشدة انحباس الصوت
+
+267
+00:22:42,430 --> 00:22:46,770
+في المخرج عند النطق بحرف الشدة لقوة اعتماد الحرفي
+
+268
+00:22:46,770 --> 00:22:52,240
+على الأخرجين ما هي حروف الشدة يا أخوات؟حروف الشدة
+
+269
+00:22:52,240 --> 00:22:58,000
+أجد قط بكت أجد قط بكت اللي هي كام حرف؟ تمان حروف
+
+270
+00:22:58,000 --> 00:23:02,740
+أجد قط بكت تمان حروف إيش معناها؟ ممكن مايكونش ليها
+
+271
+00:23:02,740 --> 00:23:06,440
+معنى لكن بدنا نعرف اللي هي الهمزة والجيم والدال
+
+272
+00:23:06,440 --> 00:23:11,060
+والقاف والطا والبا والكاف والتا صفة الشدة يا أخوات
+
+273
+00:23:11,060 --> 00:23:17,090
+هل هي صفة قوة ولا صفة ضعف؟من كلمة شدة يبقى معناها
+
+274
+00:23:17,090 --> 00:23:22,570
+طوية ومن كلمة رخامة و هي ضدها تعد ضعيفة إذا هذه
+
+275
+00:23:22,570 --> 00:23:27,390
+صفة الشدة وتثبت صفة الشدة يا أخوات في جميع أحوالها
+
+276
+00:23:27,390 --> 00:23:31,830
+سواء كانت الأحرف ساكنة أو متحركة وسط الكلام أم
+
+277
+00:23:31,830 --> 00:23:36,250
+آخره إلا أنها بتكون أوضح شيء الشدة موجودة في الحرف
+
+278
+00:23:36,250 --> 00:23:46,260
+الساكن مثال ذلك اد اب اج اط اط و هكذاالصفة الثانية
+
+279
+00:23:46,260 --> 00:23:52,720
+طبعا ضدها الرخاوة وما بين الشدة والرخاوة التوسط
+
+280
+00:23:52,720 --> 00:23:57,060
+فما معنى التوسط؟ طبعا خيره الأمور ايه؟ اوسطها
+
+281
+00:23:57,060 --> 00:24:02,720
+والتوسط هي صفة الاعتدال هي صفة معتادة ما بين الشدة
+
+282
+00:24:02,720 --> 00:24:07,500
+والرخاوة يعني لغة الاعتدال وفي الاصطلاح اعتدال
+
+283
+00:24:07,500 --> 00:24:13,040
+الصوت في المخرج عند نثق بحرف التوسط لعدم كمال
+
+284
+00:24:13,040 --> 00:24:18,330
+حباسي فيهلا نقول جريان الصوت ولا نقول انحباس الصوت
+
+285
+00:24:18,330 --> 00:24:22,870
+هو اعتدال الصوت في المخرج عند النطق بحرف التوسط
+
+286
+00:24:22,870 --> 00:24:27,830
+لعدم كمال انحباسه فيه يعني بتلاقي الصوت بيجري
+
+287
+00:24:27,830 --> 00:24:33,790
+بيمشي معناه وحروف التوسط خمسة مجموعة في قوله لن
+
+288
+00:24:33,790 --> 00:24:39,390
+عمر يعني معناه لن فعل أمر يعني كون لينا يا عمر لن
+
+289
+00:24:39,390 --> 00:24:44,970
+عمرلأن عمر يعني عندما أقول أنا ال .. ال .. يعني في
+
+290
+00:24:44,970 --> 00:24:49,430
+صوت لكن مش .. مش زي ال .. ب .. لأ هو عدم كمال
+
+291
+00:24:49,430 --> 00:24:52,950
+الحباس فيه يعني جريان الصوت .. يعني اعتدال الصوت
+
+292
+00:24:52,950 --> 00:24:56,630
+في المخرج عند النطق بحرف التوسط لعدم كمال الحباس
+
+293
+00:24:56,630 --> 00:25:01,450
+فيه فانا عندما أقول ال .. في صوت لكن برضه النفس
+
+294
+00:25:01,450 --> 00:25:09,640
+بمش معاه كذلك in ..A M R فيه صوت وفيه جريان النفس
+
+295
+00:25:09,640 --> 00:25:14,420
+لذلك لعدم كمال الحباس فيه فالمخرج لا يعتمد اعتمادا
+
+296
+00:25:14,420 --> 00:25:19,240
+كاملا على مخرجه بل في صوت ولكن بيسمح كمان بجريان
+
+297
+00:25:19,240 --> 00:25:23,780
+النفس فنقول هو اعتدال الصوت في المخرج عند النطق
+
+298
+00:25:23,780 --> 00:25:28,860
+بحرف التوسط ليش؟ لعدم كمال الحباس فيه وحروفه خمسة
+
+299
+00:25:29,230 --> 00:25:33,130
+مجموعة في قوله لين عمر يعني لكون لينا يا عمر
+
+300
+00:25:33,130 --> 00:25:38,510
+وبتثبت صفة التوسط في جميع أحوال الحرف سواء كان
+
+301
+00:25:38,510 --> 00:25:44,950
+ساكن ولا متحرك وموقوف عليه ولا يعني مقصود وصفة
+
+302
+00:25:44,950 --> 00:25:50,410
+التوسط يا أخوات هل هي صفة قوة ولا صفة ضعف؟صفة
+
+303
+00:25:50,410 --> 00:25:53,710
+اعتدال ما احنا قولنا اعتدال الصوت في المخرج هذا لا
+
+304
+00:25:53,710 --> 00:25:59,230
+هي قوية ولا هي ضعيفة بل هي معتدلة وخير الأمور
+
+305
+00:25:59,230 --> 00:26:04,350
+أوسطها وعندما نحسب الحروف هل هي قوية ولا ضعيفة صفة
+
+306
+00:26:04,350 --> 00:26:07,770
+الاعتدال لاتنحسبش يعني والله التوسط يعني مش محسوبة
+
+307
+00:26:07,770 --> 00:26:12,610
+لا مع القوية ولا مع الضعيفة بيكونوا على الحينطيب
+
+308
+00:26:12,610 --> 00:26:19,030
+ضد التوسط ضد الشدة في عندنا الرخاوة عندنا الشدة و
+
+309
+00:26:19,030 --> 00:26:23,670
+ضدها الرخاوة الشدة انحباس الصوت و الرخاوة جريان
+
+310
+00:26:23,670 --> 00:26:29,030
+الصوت في المخرج عند نطنه بحرف الرخاوة لضعف اعتماد
+
+311
+00:26:29,030 --> 00:26:33,210
+الحرف على مخرجه جريان الصوت في المخرج عند نطنه
+
+312
+00:26:33,210 --> 00:26:37,800
+بحرف الرخاوة لضعف اعتماد الحرف على مخرجهوصفة
+
+313
+00:26:37,800 --> 00:26:42,860
+الرخاوة يا اخوات يعني حروفها باقي حروف اللغة
+
+314
+00:26:42,860 --> 00:26:48,900
+العربية يعني في عندنا اشد قطبكة تمان حروفو لين عمر
+
+315
+00:26:48,900 --> 00:26:53,820
+خمس حروف هيسار و تلتاش باقي حروف اللغة العربية هي
+
+316
+00:26:53,820 --> 00:26:58,540
+حروف الرخامة يعني عندنا ننظر إلى الحرف إذا لم يكن
+
+317
+00:26:58,540 --> 00:27:03,520
+من أجد قط بكت اللي هي حروف الشدة ولم يكن من حروف
+
+318
+00:27:03,520 --> 00:27:07,080
+لين عمر اللي هي حروف التوسط مباشرة هنقول صفته إيه؟
+
+319
+00:27:07,460 --> 00:27:12,500
+صفة رخاوة، إذا حروف الرخاوة هي باقي حروف اللغة
+
+320
+00:27:12,500 --> 00:27:16,080
+العربية و هذه الصفات كلها متضادة و تثبت صفة
+
+321
+00:27:16,080 --> 00:27:19,440
+الرخاوة يا أخوات في جميع أحوالها، يعني في الساكن و
+
+322
+00:27:19,440 --> 00:27:24,320
+المتحرك و الموصول و الموقوف بالنسبة لهذا الحرف صفة
+
+323
+00:27:24,320 --> 00:27:29,140
+الرخاوة صفة قوة ولا ضعف يا أخوات؟ صفة ضعف، إذا كام
+
+324
+00:27:29,140 --> 00:27:35,540
+صفة صفتنا ماخديني الآن؟hams و ضده الجهر شدة و ضدها
+
+325
+00:27:35,540 --> 00:27:40,740
+الرخاوة و بينهما التوسط خمس صفات الhams صفة ضعف و
+
+326
+00:27:40,740 --> 00:27:48,200
+ضده الجهر صفة قوة الشدة صفة قوة و ضدها الرخاوة صفة
+
+327
+00:27:48,200 --> 00:27:54,160
+ضعف و في عندنا صفة التوسط صفة معتدلة لا محسوبة لا
+
+328
+00:27:54,160 --> 00:27:58,850
+مع الشدة ولا مع الجهرالصفة اللي بديه بعدها من
+
+329
+00:27:58,850 --> 00:28:04,030
+الصفات المتضادة الاستعلاء صفة الاستعلاء وضده صفة
+
+330
+00:28:04,030 --> 00:28:08,470
+ايش يا أخوات صفة الاستفال والاستعلاء من العلوي
+
+331
+00:28:08,470 --> 00:28:13,190
+والارتفاع فلان مستعلي او اعتلى او مبانا ارتفعة
+
+332
+00:28:13,190 --> 00:28:18,830
+وعلى وفي الاصطلاح هو ارتفاع أقصى اللسان إلى الحنك
+
+333
+00:28:18,830 --> 00:28:23,670
+الأعلى عند النطق بحرف الاستعلاء لقوة اعتماد حرف
+
+334
+00:28:23,670 --> 00:28:28,260
+على مخرجهارتفاع الأقصى اللسان إلى الحناك الأعلى
+
+335
+00:28:28,260 --> 00:28:33,380
+عند النطن بحرف الاستعلاء وحروف الاستعلاء هي سبعة
+
+336
+00:28:33,380 --> 00:28:39,060
+مجموعة في قوله خصة تنقر وهذه طبعا بترتب عليها
+
+337
+00:28:39,060 --> 00:28:43,080
+معرفة الحروف التي تفخم والحروف التي ترقق يعني
+
+338
+00:28:43,080 --> 00:28:46,220
+بيعتمد عليها اللي هي التفهيم والترقيقة اللي سوف
+
+339
+00:28:46,220 --> 00:28:50,760
+ناخده ان شاء الله تعالى يعني في الدروس القادمة هذه
+
+340
+00:28:50,760 --> 00:28:55,010
+صفة الاستعلاء كام حرف صفة الاستعلاء يا أخوات؟سبة
+
+341
+00:28:55,010 --> 00:28:59,410
+حروف مجموعة في قوله خُص ضغط قض و تثبت صفة
+
+342
+00:28:59,410 --> 00:29:03,330
+الاستعلاء كذلك في جميع أحوالها يعني الحرف لو كان
+
+343
+00:29:03,330 --> 00:29:11,490
+متوسطا او متطرفا موصولا او موقوفا متحركا او ساكنا
+
+344
+00:29:11,490 --> 00:29:15,870
+في جميع أحواله بتلاقي ملزن فيه لأن هذه الصفات
+
+345
+00:29:15,870 --> 00:29:21,350
+اللتي ندرسها هي صفات ملازمة لازمة ولا صفات عرضية
+
+346
+00:29:21,800 --> 00:29:25,900
+لازم، إذا ملسق في الحرف، ملازم للحرف في جميع
+
+347
+00:29:25,900 --> 00:29:31,200
+أحواله، سواء كان فيه متوسطا ولا متطرفا، موصولا ولا
+
+348
+00:29:31,200 --> 00:29:36,880
+موقوفا، ساكنا ولا متحركا، فصفة الاستعلاء صفة لازمة
+
+349
+00:29:36,880 --> 00:29:41,680
+للحرف، وصفة الاستعلاء يا أخوات صفة قوة ولا صفة ضعف
+
+350
+00:29:43,030 --> 00:29:47,430
+أه صفة قوة و ضد الاستعلاء صفة ايش الاستفال
+
+351
+00:29:47,430 --> 00:29:52,030
+الاستفال ضده ضد الاستعلاء والاستفال يا اخوات يعني
+
+352
+00:29:52,030 --> 00:29:57,350
+هو من معناته الانخفاض والانحطاف والاستفال اصطلاحا
+
+353
+00:29:57,350 --> 00:30:01,710
+انخفاض أقصى اللسان عن الحنك الأعلى إلى قاع الفمي
+
+354
+00:30:01,710 --> 00:30:06,180
+عند النطق بحرف الاستفال يعني زي ما قلنافي
+
+355
+00:30:06,180 --> 00:30:10,640
+الاستعلاء ارتفاع اللسان إلى الحنك الأعلى عند النطق
+
+356
+00:30:10,640 --> 00:30:15,940
+بحرف الاستعلاء نقول الاستفال عكسه مش ارتفاع هو
+
+357
+00:30:15,940 --> 00:30:20,440
+انخفاض اللسان إلى قاع الفمي عند النطق بحرف
+
+358
+00:30:20,440 --> 00:30:26,270
+الاستفال وحروف الاستفال ما هي؟باقي حروف اللغة
+
+359
+00:30:26,270 --> 00:30:30,550
+العربية و طبعا احنا قلنا ايضا تثبت صفة الاستفال
+
+360
+00:30:30,550 --> 00:30:36,090
+للحرف جميع أحواله و حروف الاستفال هل هي صفة قوة
+
+361
+00:30:36,090 --> 00:30:41,950
+ولا صفة ضعف؟صفات ضعيفة مثال و ذلك مثلا كلمة باطل
+
+362
+00:30:41,950 --> 00:30:49,430
+تائب سائب سائل حرف الصين هذا عبارة عن حروف استفال
+
+363
+00:30:49,430 --> 00:30:56,750
+وهي مرققة فلبد أن تكون يعني نخرجها و بتكون صفتها
+
+364
+00:30:56,750 --> 00:31:02,810
+صفات ضعيفةفي عندنا كمان صفة الإطباق و ضده
+
+365
+00:31:02,810 --> 00:31:07,490
+الاستعلاء صفة الإطباق و ضده الاستعلاء طبعا الإطباق
+
+366
+00:31:07,490 --> 00:31:12,290
+مانته إيش يا أخوات أطبقت
+
+367
+00:31:12,290 --> 00:31:15,810
+الشاي بمعنى ألسقته إذا الإطباق من حيث اللغة
+
+368
+00:31:15,810 --> 00:31:20,430
+الإلساق و في الإصطلاح إلتساق طائفة من اللسان
+
+369
+00:31:20,430 --> 00:31:26,150
+بالحنك الأعلى عند النطق بحرف الإطباق فينحصر الصوت
+
+370
+00:31:26,150 --> 00:31:32,220
+بينهمالاتصاق طائفة من اللسان، بنلاقي طائفة من
+
+371
+00:31:32,220 --> 00:31:36,340
+اللسان سواء كان وسطه ولا أقصى اللسان، بيلتسق
+
+372
+00:31:36,340 --> 00:31:40,440
+بالحنك الأعلى التصاقا، فيمنع الصوت وبيمنع النفس
+
+373
+00:31:40,440 --> 00:31:47,700
+وله قوة، فبنسمي هذا استعلاء، إذا الإطباق هو التصاق
+
+374
+00:31:47,700 --> 00:31:51,940
+طائفة من اللسان بالحنك الأعلى عند النطق بحرف
+
+375
+00:31:51,940 --> 00:31:56,320
+الإطباق فينحصر الصوت بينهما، لكن ما هي حروف
+
+376
+00:31:56,320 --> 00:32:04,030
+الإطباق؟حروف الأطباق أربعة حروف اللي هي الأط والأض
+
+377
+00:32:04,030 --> 00:32:09,910
+والأص والأض من حيث القوة يعني أول أقوى شئ حرف الأط
+
+378
+00:32:09,910 --> 00:32:15,310
+بيلاقي أط ببيتفع اللسان إلى اللحنك الأعلى وبيلتسف
+
+379
+00:32:15,310 --> 00:32:22,510
+وجميع صفات حرف الأط ب هو صفات قوة يليه الأضالأض
+
+380
+00:32:22,510 --> 00:32:26,590
+حرف الأض اللي بيخرج من إحدى حرفتان اللسان اليمنى
+
+381
+00:32:26,590 --> 00:32:30,610
+أو اليسرة مع ما يريه من أضلاص الجهة العلية بيخرج
+
+382
+00:32:30,610 --> 00:32:37,170
+منه حرف الضال فيأتي بالترتيب بعده ثم الأص ثم الأض
+
+383
+00:32:37,170 --> 00:32:41,370
+من حيث القوة وكلها تسمى حروف الأطباق الحروف
+
+384
+00:32:41,370 --> 00:32:46,730
+الأطباق الأط والأض والأص والأض وهي مرتبة على هذا
+
+385
+00:32:46,730 --> 00:32:48,570
+الحال مثل الط
+
+386
+00:32:59,490 --> 00:33:05,410
+و تثبت طبعا صفة الإطباق لحرف جميع أحواله و صفة
+
+387
+00:33:05,410 --> 00:33:11,410
+الإطباق صفة قوة و الإطباق أخصه من الاستعلام ليش يا
+
+388
+00:33:11,410 --> 00:33:16,070
+أخوة الإطباق أخصه من الاستعلام الاستعناء حروفه خُص
+
+389
+00:33:16,070 --> 00:33:22,060
+صداق انقذ سبب حروفالاطباق موجودة في حروف الاستعلاء
+
+390
+00:33:22,060 --> 00:33:25,740
+اللي هي الصاد والضاد والطا والظهر جزء من حروف
+
+391
+00:33:25,740 --> 00:33:31,280
+الاستعلاء لذلك اخصه من الاستعلاء فكل حرف من حروف
+
+392
+00:33:31,280 --> 00:33:37,520
+الاطباق هو استعلاءوليس العكس وليس كل استعلاء إطباق
+
+393
+00:33:37,520 --> 00:33:43,280
+لأن هناك بعض الحروف حرف الخ وغيره و القاف لا تعد
+
+394
+00:33:43,280 --> 00:33:48,700
+من حروف الإطباق وصفة الإطباق كما قلنا هي صفة قوة
+
+395
+00:33:48,700 --> 00:33:53,860
+وضدها صفة إيش يا أخوات صفة الانفتاح والانفتاح ضد
+
+396
+00:33:53,860 --> 00:33:58,340
+الإطباق ومعنى الانفتاح هو الافتراكالاطباق هو
+
+397
+00:33:58,340 --> 00:34:03,160
+الاتصاق طائفة من اللسان بالحלק الأعلى هنا الانفتاح
+
+398
+00:34:03,160 --> 00:34:08,120
+افتراق طائفة او افتراق اللسان عن الحלק الأعلى عند
+
+399
+00:34:08,120 --> 00:34:13,480
+النطق بحرف الانفتاح فلا ينحصر الصوت بينهما وحروف
+
+400
+00:34:13,480 --> 00:34:18,500
+الانفتاح يا أخوات هي باقي حروف اللغة العربية
+
+401
+00:34:18,500 --> 00:34:25,580
+والأمثل على ذلك كثيرة ومتعددة مثل حنيدمجيد خاسرون
+
+402
+00:34:25,580 --> 00:34:31,160
+فكل ال ح وال ج و الصين كل هذه حروف انفتاح ولا
+
+403
+00:34:31,160 --> 00:34:35,660
+تعدوا من حروف الإطباع حروف الانفتاح كذا يا أخوات
+
+404
+00:34:35,660 --> 00:34:40,720
+أعموا من الاستفال يعني حروف الانفتاح أكثر الاستفال
+
+405
+00:34:40,720 --> 00:34:46,260
+أقل يعني كل استفال هو انفتاح وليس كل حرف من حروف
+
+406
+00:34:46,260 --> 00:34:47,980
+الانفتاح استفال
+
+407
+00:34:49,920 --> 00:34:54,040
+آخر صفتين متضادتين يا أخوات هي صفة الإذلاق و ضده
+
+408
+00:34:54,040 --> 00:34:58,840
+الإصناق والإذلاق معناه هو الفصاحة والبلاغة والخفة
+
+409
+00:34:58,840 --> 00:35:03,040
+نقول فلان ذلق اللسان يعني الكلام والشعر أو اللي
+
+410
+00:35:03,040 --> 00:35:08,620
+ينساقه من اللسان بسهولة بل إنسان بليغكلامه جميل
+
+411
+00:35:08,620 --> 00:35:14,600
+يعني زي أديب أو شاعر اسمه ذلق اللسان إذا من حياته
+
+412
+00:35:14,600 --> 00:35:19,120
+اللغة الإذلاق لغة الفصاحة والبلاغة والخفة وفي
+
+413
+00:35:19,120 --> 00:35:24,480
+الاصطلاح هو خفة الحرفي وسرعة النطق به لخروجه من
+
+414
+00:35:24,480 --> 00:35:29,920
+ذلق اللساني أو الشفة أو الشفتيمانإذا الإذلاق هو
+
+415
+00:35:29,920 --> 00:35:35,420
+خفة الحرفي و سرعة الإنطلاق به لخروجه من ذلق اللسان
+
+416
+00:35:35,420 --> 00:35:39,640
+إيش يعني ذلق اللسان؟ يعني طرف اللسان أو الشفة يعني
+
+417
+00:35:39,640 --> 00:35:44,400
+الشفة الواحدة أو الشفتين معاهم لأن حروفه مجموعة في
+
+418
+00:35:44,400 --> 00:35:50,060
+قوله ثرة من لبن ما معنى أخوات ثرة من لبن؟مالهاش
+
+419
+00:35:50,060 --> 00:35:56,240
+معنى لكن اف فره الفاره ميم نون لبه يعني ست حروف
+
+420
+00:35:56,240 --> 00:36:01,940
+فره من لنبن ال و هذه الحروف بتخرج من ذلق اللساني
+
+421
+00:36:01,940 --> 00:36:06,080
+او الشفة او الشفتين معنى ذلق اللسان يعني طرف
+
+422
+00:36:06,080 --> 00:36:11,720
+اللسان اللي هو حرف اللام و الرا ال و ار تخرج من
+
+423
+00:36:11,720 --> 00:36:16,100
+طرف اللسان يعني من ذلق اللسان او الشفة يعني الشفة
+
+424
+00:36:16,100 --> 00:36:20,450
+الواحدة مثل حرف ال افمن أين يخرج حرف ال F يا
+
+425
+00:36:20,450 --> 00:36:24,250
+أخوات؟ اللي هي من بطن الشفة السفلة أو أطراف الثناء
+
+426
+00:36:24,250 --> 00:36:27,650
+العليا على بطن الشفة السفلة يعني مابنفع نقول من
+
+427
+00:36:27,650 --> 00:36:31,870
+بطن الشفة السفلة فقط لإن الواحد لو عمل هيكة بس
+
+428
+00:36:31,870 --> 00:36:36,870
+يعني و لا يتخرج حرف الفا فالنبود أن يلتقي أطراف
+
+429
+00:36:36,870 --> 00:36:40,350
+الثناء العليا على بطن الشفة السفلة فبيخرج منه حرف
+
+430
+00:36:40,350 --> 00:36:46,460
+الفاأو الشفتين معانا اللي هي ال M و ال IB إذا صفة
+
+431
+00:36:46,460 --> 00:36:51,840
+الذلاق خفة الحرفي و سرعة نطقه بيه لخروجه من ذلق
+
+432
+00:36:51,840 --> 00:36:56,940
+اللساني اللي هو ال Lam و ال .. و النون .. او ال
+
+433
+00:36:56,940 --> 00:37:02,840
+Lam و ال Ra و الشفة A اللي هي الحرف الفا و ال ..
+
+434
+00:37:02,840 --> 00:37:07,060
+أو الشفتين معانا اللي هو ال M و ال B فرة من لبن
+
+435
+00:37:08,540 --> 00:37:14,420
+لماذا يسمى ذلقي؟ لخفته وسرعته وصفة الإذلاق صفة
+
+436
+00:37:14,420 --> 00:37:21,040
+توسط وكذلك صفة الإصمات أيضا صفة توسط فالصفات
+
+437
+00:37:21,040 --> 00:37:25,860
+التوسط الأذلاق والاصمات توسط مش محسوبة على القوي
+
+438
+00:37:25,860 --> 00:37:30,900
+ولا على الضايفو كذلك التوسط مع الشدة والرخاوة و
+
+439
+00:37:30,900 --> 00:37:35,520
+بينها والتوسط لا تعد صفة قوة ولا صفة ضعف الإسماط
+
+440
+00:37:35,520 --> 00:37:39,740
+يا أخوات هي ضد الإدلاق والإسماط منع انفراد حروف
+
+441
+00:37:39,740 --> 00:37:44,560
+الإسماط في أصول الكلمات الرباعية أو الخماسية لثقة
+
+442
+00:37:44,560 --> 00:37:48,680
+لها وعدم النطق بيها لبعد مخرجها عن ذلق اللسان أو
+
+443
+00:37:48,680 --> 00:37:54,500
+الشفةيبقى معناة الإصمار منع انفراد حروف الإصمار
+
+444
+00:37:54,500 --> 00:37:59,800
+يعني لا يصح لنا أن تكون الكلمة التي هي أصل الكلمة
+
+445
+00:37:59,800 --> 00:38:04,060
+ربعية أو خماسية جميع حروفها حروف إصمار لابد أن
+
+446
+00:38:04,060 --> 00:38:08,300
+يتوفر فيها أحد حروف فر من لب عشان تكون الكلمة
+
+447
+00:38:08,300 --> 00:38:13,620
+عربيةأما إذا وردت بعض الكلمات الخماسية أو الربعية
+
+448
+00:38:13,620 --> 00:38:17,600
+أو الخماسية وجميع حروفها حروف أسماط معنى هذه أن
+
+449
+00:38:17,600 --> 00:38:23,020
+هذه الكلمة ليست عربية مثل كلمة إيش أستاذ أستاذ هي
+
+450
+00:38:23,020 --> 00:38:27,280
+كلمة فارسية وليست كلمة عربية يعني عندنا معلم لكن
+
+451
+00:38:27,280 --> 00:38:32,560
+كلمة أستاذ هي كلمة عُربت إلينا كذلك كلمة عسجد عسجد
+
+452
+00:38:32,560 --> 00:38:37,480
+معناته الذهب باللغة الفارسية عسجد معناته الذهب لكن
+
+453
+00:38:37,480 --> 00:38:42,090
+عندنا احنا اسمه ذهبو لأن كلمة عسجد رباعية و لا
+
+454
+00:38:42,090 --> 00:38:46,510
+يوجد فيها أي حرف من حروف فرة من لبن فهي إيش تصنع و
+
+455
+00:38:46,510 --> 00:38:49,910
+كذلك كلمة أستاذ لا يوجد فيها أي حرف من حروف فرة من
+
+456
+00:38:49,910 --> 00:38:54,970
+لبن إذا بتكون كلمة أستاذ كلمة ليست عربية و بهذه يا
+
+457
+00:38:54,970 --> 00:38:58,570
+أخوات منكون احنا خلصنا الجزء الأول من الصفات و هي
+
+458
+00:38:58,570 --> 00:39:02,560
+الصفات المتضادة الهمس و ضده الجهرالشدة و ضدها
+
+459
+00:39:02,560 --> 00:39:06,240
+الرخاوة و بينهم التوسط الاستعلاء و ضده الاستفال
+
+460
+00:39:06,240 --> 00:39:11,120
+الأطباق و ضده الفتاح الإذلاق و ضده الإصمات انتهينا
+
+461
+00:39:11,120 --> 00:39:13,580
+من الصفات المتضادة و ان شاء الله في المحاضرة
+
+462
+00:39:13,580 --> 00:39:17,000
+القادمة بناخد الصفات اللتي تليها و هي الصفات اللتي
+
+463
+00:39:17,000 --> 00:39:20,040
+ليس لها ضد نكتفي بهذا القدر و برك الله فيكم و
+
+464
+00:39:20,040 --> 00:39:22,000
+السلام عليكم و رحمة الله و بركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_raw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_raw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..b453f77daf7b4e8f50831f8af3d70951045e227d
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/e3UEAUAQw8Y_raw.srt
@@ -0,0 +1,1856 @@
+1
+00:00:11,520 --> 00:00:14,340
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:14,340 --> 00:00:18,700
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+3
+00:00:18,700 --> 00:00:22,320
+آله وصحابه وسلم أخدنا يا أخوات في المحاضرة الماضية
+
+4
+00:00:22,320 --> 00:00:27,620
+المخارج وبين أن هناك مخارج عامة ومخارج خاصة أخدنا
+
+5
+00:00:27,620 --> 00:00:31,360
+المخارج العامة اللي هو الجوفوالحلق، اللسان،
+
+6
+00:00:31,360 --> 00:00:35,460
+الشفتان، الخشوم، ثم أخدنا بعد ذلك ما ينبثق عن هذه
+
+7
+00:00:35,460 --> 00:00:39,360
+المخارج عامة من المخارج الخاصة سبعة عشر مخرجا
+
+8
+00:00:39,360 --> 00:00:44,180
+فرعيا و اليوم إن شاء الله بناخد أيضا الصفات و هو
+
+9
+00:00:44,180 --> 00:00:47,920
+الشطر الثاني من هذا الموضوع الذي هو المخارج
+
+10
+00:00:47,920 --> 00:00:52,480
+والصفات أما بالنسبة للصفات يا أخوات فهو جمع صفة
+
+11
+00:00:53,120 --> 00:00:58,320
+والصفة معناتها من حيث اللغة هو ما قام بالشيء من
+
+12
+00:00:58,320 --> 00:01:03,020
+المعاني حسيا كان كالبياضي والسوادي أو معنويا
+
+13
+00:01:03,020 --> 00:01:07,680
+كالكرمي والشجاعة والعلمي والجهل ونحو ذلك يعني هذا
+
+14
+00:01:07,680 --> 00:01:11,470
+من حيث اللغةيعني ما أقوم بالشيء من المعنى نقوله
+
+15
+00:01:11,470 --> 00:01:18,050
+هذا أبيض أسود طويل قصير هذا حسي أو معنوي نقول مثلا
+
+16
+00:01:18,050 --> 00:01:25,470
+كريم شجاع ذكي غبي متعلم جاهل و هكذا هذا من حياته
+
+17
+00:01:25,470 --> 00:01:30,510
+اللغة أما من حياته الإصطلاح فالصفة هي كيفية تثبت
+
+18
+00:01:30,510 --> 00:01:37,350
+للحرف عند النطق به فيتميزه عن غيره من الأحرفكيفية
+
+19
+00:01:37,350 --> 00:01:43,550
+تثبت؟ يعني مثلا في عندنا الغنى، في عندنا الشدة،
+
+20
+00:01:43,550 --> 00:01:48,450
+الجهر، الخفاء وغير ذلك من الصفات أما بالنسبة
+
+21
+00:01:48,450 --> 00:01:52,410
+للفائدة من تعريفنا للصفات، يعني ما الفائدة التي
+
+22
+00:01:52,410 --> 00:01:58,130
+يمكن أن نجدها عندما نتعرف أو ندرس موضوع الصفات أو
+
+23
+00:01:58,130 --> 00:02:05,130
+فوائد معرفة الصفات، ما هي أخوات؟ فضليأول شي تمييز
+
+24
+00:02:05,130 --> 00:02:09,560
+الحروف المشتركة في المخرجيعني كل مخرج له حروف
+
+25
+00:02:09,560 --> 00:02:13,680
+معينة بعض المخرج بتخرج صفة او حرف واحد وبعض المخرج
+
+26
+00:02:13,680 --> 00:02:18,520
+تخرج تلت صفات او اكثر او اقل عندنا مثلا مخرج حرف
+
+27
+00:02:18,520 --> 00:02:23,720
+ال ميم والباب ام اب كلا هما يخرجوا عند انطباق
+
+28
+00:02:23,720 --> 00:02:28,920
+الشفتين لكن صفة ال ميم تختلف عن صفة الباب صفة
+
+29
+00:02:28,920 --> 00:02:34,860
+الباب عند انطباق الشفتين بتخرج القلق نقول ابوصفة
+
+30
+00:02:34,860 --> 00:02:39,580
+الـ Meme برضه عند انطباق الشفتين ولكنها بتخرج منها
+
+31
+00:02:39,580 --> 00:02:46,000
+صفة الغنى إذا من ضمن ثوائد معرفتنا للصفات اللي هو
+
+32
+00:02:46,000 --> 00:02:49,560
+تمييز الحروف المشتركة في المخرج فلو لا الصفات لمّا
+
+33
+00:02:49,560 --> 00:02:53,580
+سطعنا أن نتعرف على هذه الحروف مع أن مخرج ال ميم
+
+34
+00:02:53,580 --> 00:02:58,160
+والبا مخرجهم واحد إلا أن صفة البا قلقلق وصفة ال
+
+35
+00:02:58,160 --> 00:03:02,360
+ميم غنى فالميم فيها غنى من تمييزنا عن حرف البا
+
+36
+00:03:02,360 --> 00:03:10,640
+كذلك ال itوالاط و الاد الاط فيها قلقلة والاد فيها
+
+37
+00:03:10,640 --> 00:03:16,160
+همس فالاد تختلف عن الأط لذلك الصفات يستطيعون من
+
+38
+00:03:16,160 --> 00:03:20,320
+خلالها تمييز الحروف المشتركة في المخرج الواحد
+
+39
+00:03:20,320 --> 00:03:26,270
+الفايدة الثانية يا أخوان هي فضل أختمعرفة الحروف
+
+40
+00:03:26,270 --> 00:03:29,630
+القوية من الحروف الضعيفة طبعا نحن ان شاء الله سوف
+
+41
+00:03:29,630 --> 00:03:33,750
+ناخد من خلال دراستنا للصفات أن هناك صفات قوية
+
+42
+00:03:33,750 --> 00:03:39,650
+وصفات ضعف مثلا في عندنا صفة الهمس صفات ضعف ضدها
+
+43
+00:03:39,650 --> 00:03:44,870
+الجهر صفات قوة في عندنا الشدة صفات قوة ضدها
+
+44
+00:03:44,870 --> 00:03:49,970
+الرقابة صفات ضعف الاستعلاء صفات قوة ضدها الاستفاد
+
+45
+00:03:49,970 --> 00:03:54,490
+صفات ضعف و هكذا إذا الصفات التي سوف ندرسها فيها
+
+46
+00:03:54,490 --> 00:04:00,020
+صفات قوةوصفات ضعف لذلك يعني نستطيع أن نتعرف على
+
+47
+00:04:00,020 --> 00:04:03,940
+الحروف القوية من الحروف الضعيفة من خلال تعريفنا
+
+48
+00:04:03,940 --> 00:04:07,840
+على الصفات طب ماذا نستفيد عندما نعرف أن هذا الحرف
+
+49
+00:04:07,840 --> 00:04:11,860
+قوي ولا هذا الحرف ضعيف؟ ماذا يمكن أن نستفيد يا
+
+50
+00:04:11,860 --> 00:04:19,300
+أخوات؟ فضليصحيح نستطيع أن نعرف الحرف الذي يضغم في
+
+51
+00:04:19,300 --> 00:04:23,800
+غيره أو الحرف الذي لا يضغم في الذي يليه إذا كان
+
+52
+00:04:23,800 --> 00:04:28,860
+الحرف الضعيف الضعيف بيضغم في القوي لكن القوي لا
+
+53
+00:04:28,860 --> 00:04:35,310
+يضغم في الضعيف مثال ذلك هنافأمن الطائفة الطا هنا
+
+54
+00:04:35,310 --> 00:04:42,150
+صفتها ضعيفة والأط صفات طوة فالطا بتضغم في الطا لأن
+
+55
+00:04:42,150 --> 00:04:47,010
+الطا ضعيفة بتضغم في الطا القوية مثال و ذلك لو في
+
+56
+00:04:47,010 --> 00:04:53,350
+عندنا إناء واسع وإناء صغير الإناء الصغير يضغم أو
+
+57
+00:04:53,350 --> 00:04:57,910
+يدخل في الإناء الواسع لكن الإناء الواسع لا يدخل في
+
+58
+00:04:57,910 --> 00:05:03,690
+الإناء الضيقهنا مثلا في أمن الطائفة التى دخلت
+
+59
+00:05:03,690 --> 00:05:10,210
+فالطى مباشرة بينما في عندما نقرأ كلمة أحتو الطى
+
+60
+00:05:10,210 --> 00:05:17,110
+صفت قوة والتى صفت ضعف فلنقول أحتو لا تضغم الطى
+
+61
+00:05:17,110 --> 00:05:23,210
+بالتى لأن الطى لو أضغمت بالتى تقرأ أحتو لكنها ليست
+
+62
+00:05:23,210 --> 00:05:30,140
+أحتو هي أحتو يعني تظهر الطى أحتوتو الطار تظهر و
+
+63
+00:05:30,140 --> 00:05:34,300
+الطا وبالتالي لا تضغم في هذه الإضغامة كاملا بينما
+
+64
+00:05:34,300 --> 00:05:40,380
+في أمنات طائفة الطا تدخل كلها ذاتها وصفاتها في حرف
+
+65
+00:05:40,380 --> 00:05:43,600
+الطا وبالتالي ممكن نسميه إضغام وأما بالنسبالي اللي
+
+66
+00:05:43,600 --> 00:05:47,740
+أحطته فلا يوجد إضغام كامل ماشي هذه الفائدة الثانية
+
+67
+00:05:47,740 --> 00:05:49,940
+الفائدة الثالثة يا بنات فضلي
+
+68
+00:05:52,800 --> 00:05:56,240
+من فوائد معرفتنا يا أخوات للصفات أيضا تحسين النطق
+
+69
+00:05:56,240 --> 00:06:02,660
+بالحروف المختلفة في المخارج مثلا عندنا الath والis
+
+70
+00:06:03,370 --> 00:06:10,210
+ازاي ال is نقول is و ال .. و ال if نقول if ذلك
+
+71
+00:06:10,210 --> 00:06:15,950
+الكتاب مثلا الذين الذي .. لكن لا نقول الذين و الذي
+
+72
+00:06:15,950 --> 00:06:21,430
+و ذلك لأن هذا حرف يعني له مخرج غير عن الحرف الثاني
+
+73
+00:06:21,430 --> 00:06:27,100
+كذلك عندما نقول الحقفالقهف هنا فيها قلقلة أو
+
+74
+00:06:27,100 --> 00:06:32,600
+مقتدرة مقتدرة أيضا فيها قلقلة ولكنها قلقلة صغيرة
+
+75
+00:06:32,600 --> 00:06:37,660
+في عندنا مثلا تبت يد أبي لهبي و تب ال ب فيها قلقلة
+
+76
+00:06:37,660 --> 00:06:44,540
+أو مثلا في عندنا صفات الهمس مثال ذلك ال itقالت فتة
+
+77
+00:06:44,540 --> 00:06:48,820
+فيها همس أو فيها قلقلة أو فيها و هكذا يعني نستطيع
+
+78
+00:06:48,820 --> 00:06:52,700
+أن نحسم النطق بالحروف المختلفة في المخرج الواحد
+
+79
+00:06:52,700 --> 00:06:56,980
+إذا فائدة معرفتنا للصفات تلاتة تمييز الحروف
+
+80
+00:06:56,980 --> 00:07:00,200
+المشتركة في المخرج الواحد فلو للصفات لمّا استطعنا
+
+81
+00:07:00,200 --> 00:07:03,770
+أن نميز ما بينهاالحروف التي مخرجها واحد مثل حرف
+
+82
+00:07:03,770 --> 00:07:07,170
+البا وحرف ال ميم، اتنين معرفة الحروف القوية من
+
+83
+00:07:07,170 --> 00:07:11,370
+الحروف الضعيفة اذ ان الصفات فيها صفات قوة وصفات
+
+84
+00:07:11,370 --> 00:07:15,210
+ضعف فنعرف ان هذا الحرف ضعيف و هذا الحرف قوي من
+
+85
+00:07:15,210 --> 00:07:19,710
+كثرة الصفات الضعيفة او القويةونستفيد من هذا الأمر
+
+86
+00:07:19,710 --> 00:07:24,270
+معرفة الحرف الذي يضغم من الحرف الذي لا يضغم الحرف
+
+87
+00:07:24,270 --> 00:07:27,890
+الضعيف يضغمه في الحرف القوي لكن الحرف القوي لا
+
+88
+00:07:27,890 --> 00:07:31,210
+يضغمه في الحرف الضعيف رقم تلاتة تحسين النطق
+
+89
+00:07:31,210 --> 00:07:36,290
+بالحروف المختلفة في المخرج الواحد كذلك يا أخوات
+
+90
+00:07:36,290 --> 00:07:43,130
+تنقسم صفات الحروف إلى قسمين صفات ذاتية وصفات عرضية
+
+91
+00:07:44,350 --> 00:07:47,210
+الصفات الذاتية يا أخوات هي الصفات المنازمة للحرف و
+
+92
+00:07:47,210 --> 00:07:51,750
+التي لا تنفك عنه بأي حال من الأحوال صفات ذاتية
+
+93
+00:07:51,750 --> 00:07:57,250
+يعني ملسقة و ملزمة بالحرف لا تنفك عنه مثل القلقلة
+
+94
+00:07:57,250 --> 00:08:02,970
+والجهرالقلقلة صفة ذاتية والجهر صفة ذاتية والشدة
+
+95
+00:08:02,970 --> 00:08:07,390
+والرخابة والهمس كل صفات ذاتية وهي الصفات التي سوف
+
+96
+00:08:07,390 --> 00:08:11,430
+ندرسها لا تنفك عن أي حرف من هذه الحروف بأي حالة من
+
+97
+00:08:11,430 --> 00:08:14,510
+الأحوال سواء كان جاء الحرف لوحده ولا جاء في وسط
+
+98
+00:08:14,510 --> 00:08:18,230
+الكلمة ولا جاء في نهاية الكلمة نأتي بالمثال مثلا
+
+99
+00:08:18,230 --> 00:08:26,710
+عندما نقول مثلا الحق القلقلة ظهرت الحقو لو جينا به
+
+100
+00:08:26,710 --> 00:08:33,470
+لوحده نقول اق برضه ملزم في الحرف كذلك لو جينا بوصل
+
+101
+00:08:33,470 --> 00:08:38,650
+الكلمة نقول مقتدرا القاف أيضا تقلقل ولكنها قلقلة
+
+102
+00:08:38,650 --> 00:08:43,690
+صغيرة و كذلك أي صفة من هذه الصفات و كذلك صفة الجهر
+
+103
+00:08:43,690 --> 00:08:47,730
+والشدة والاستعلاء وغير ذلك من الصفات التي سوف
+
+104
+00:08:47,730 --> 00:08:52,600
+ندرسها و كلها صفات ذاتيةأما الصفات العرضية وهي
+
+105
+00:08:52,600 --> 00:08:57,100
+الصفات التي يتصف بها الحرف أحيانا ويفارقه أحيانا،
+
+106
+00:08:57,100 --> 00:09:00,840
+يعني .. يعني تلازم الحرف في حالات وتفارقه في
+
+107
+00:09:00,840 --> 00:09:05,440
+حالات، يعني نعرف حسب موقعه، مثلا التفخيم والترقيد
+
+108
+00:09:06,840 --> 00:09:11,900
+حسب يعني فخم مثلا زي الألف مثلا تفخم الألف أو تفخم
+
+109
+00:09:11,900 --> 00:09:14,860
+اللام في لفظ الجلالة أو الرا انشوف مثلا اللام في
+
+110
+00:09:14,860 --> 00:09:18,720
+لفظ الجلالة متى تفخم اللام في لفظ الجلالة لو كان
+
+111
+00:09:18,720 --> 00:09:23,920
+ما قبلها مفتوح أو مضمون من يأتي بمثال فيه تفخيم
+
+112
+00:09:23,920 --> 00:09:25,480
+اللام في لفظ الجلالة؟
+
+113
+00:09:30,050 --> 00:09:36,350
+صحيح ألف لاميم الله لا إله ولا حي القيوم لأ شيء ..
+
+114
+00:09:36,350 --> 00:09:43,150
+شيء ثاني إن الله .. إن الله أسهر في لفظ الجلالة
+
+115
+00:09:43,150 --> 00:09:50,190
+قلنا الله بينفع نقول إن اللهلأ إن الله وملائكته أو
+
+116
+00:09:50,190 --> 00:09:57,410
+رسول الله ناقة الله كتاب الله اللام تفخم لأنها
+
+117
+00:09:57,410 --> 00:10:03,950
+مسبقة بفتح إن الله أو بضم رسول الله لكنها ترقق إذا
+
+118
+00:10:03,950 --> 00:10:08,130
+سبقها حرف مكسور من يأتي بمثال ترقق فيه اللام
+
+119
+00:10:08,130 --> 00:10:13,090
+تفضليهبسم الله الرحمن الرحيم لما قول بسم الله
+
+120
+00:10:13,090 --> 00:10:17,350
+الرحمن الرحيم لأن اللام في لفظ الجلالة إذا سبقها
+
+121
+00:10:17,350 --> 00:10:22,710
+مكسور ترقق وإذا سبقها مفتوح أو مضموم تفخم فالتفخيم
+
+122
+00:10:22,710 --> 00:10:28,390
+والترقيق صفات عرضية كذلك في عندنا الألف الألف تفخم
+
+123
+00:10:28,390 --> 00:10:31,890
+أيضا في حالات و ترقق في حالات ماذا تفخم الألف ..
+
+124
+00:10:31,890 --> 00:10:38,470
+فضل أختحسب ما قبلها إن كان ما قبلها مفخما فخمة مثل
+
+125
+00:10:38,470 --> 00:10:42,870
+الطامة
+
+126
+00:10:42,870 --> 00:10:46,850
+ولا الضالين
+
+127
+00:10:46,850 --> 00:10:51,290
+حرف الضاد حرف استعلاء اللي بعده مدام اللي ما سبق
+
+128
+00:10:51,290 --> 00:10:57,090
+الألف مفخم إذا الألف تفخم وإذا سبقها مراقق تراقع
+
+129
+00:10:57,090 --> 00:11:03,420
+منهيت بمثالالسائلين، السائلين، ما بنقولش الصائلين
+
+130
+00:11:03,420 --> 00:11:09,380
+أو النار، ما بنقولش النار، النار، النون مراققة،
+
+131
+00:11:09,380 --> 00:11:13,820
+إذا نقلف اللي بعدها مراققة كذلك الرأ أيضا تفخم في
+
+132
+00:11:13,820 --> 00:11:17,820
+حالات و ترقق في حالات تفخم الرأ لو كانت مضمومة أو
+
+133
+00:11:17,820 --> 00:11:24,380
+مفتوحة، نقول رأةرؤيا الرأى مفخر نقول نملأ بها الفم
+
+134
+00:11:24,380 --> 00:11:30,340
+لكن عندما تكون مكسورة ترقق نقول بريحن بريحن ا
+
+135
+00:11:30,340 --> 00:11:35,080
+فرعون فرعون يعني الرأى دول بتكون ظاهرة لأنها بتكون
+
+136
+00:11:35,080 --> 00:11:40,550
+مرققةإذا صفات ذاتية وصفات عرضية الصفات الذاتية هي
+
+137
+00:11:40,550 --> 00:11:44,250
+الصفات التي تلازم الحرف بكل أحواله ولا تفارقه بأي
+
+138
+00:11:44,250 --> 00:11:48,110
+حالة من الأحوال مثل الشدة والجهر والرخاء
+
+139
+00:11:48,110 --> 00:11:51,470
+والاستعلاء والاستفال والاطباق والإذلاق الصفات التي
+
+140
+00:11:51,470 --> 00:11:55,070
+سوف ناخدهاأما الصفات العرضية هي صفات قليلة وهي
+
+141
+00:11:55,070 --> 00:11:58,690
+صفات التفخيم والتعقيد تفخن بعض الحروف في حلات
+
+142
+00:11:58,690 --> 00:12:03,010
+وترقق في حلات ومعنى الصفات العرضية هي الصفات التي
+
+143
+00:12:03,010 --> 00:12:06,990
+تلازم الحرف في حلات وتفارقهم في حلات الصفات التي
+
+144
+00:12:06,990 --> 00:12:12,450
+سوف ندرسها يا أخوات هي ايه الصفات الذاتية الصفات
+
+145
+00:12:12,450 --> 00:12:17,730
+الذاتية الملازمة للحرف وهي كم صفة؟عشرون صفة سوف
+
+146
+00:12:17,730 --> 00:12:22,490
+ندرسها بعض العلماء قال له لأ هي تمانتاشر صفة لكن
+
+147
+00:12:22,490 --> 00:12:30,710
+يضاف عليها صفة الخفاء والغنى صارت عشرين أما
+
+148
+00:12:30,710 --> 00:12:33,110
+بالنسبة للصفات اللتي سوف ندرسها ان شاء الله اللي
+
+149
+00:12:33,110 --> 00:12:38,330
+هي العشرون صفة في عندنا صفات متضادةيعني لها ضد
+
+150
+00:12:38,330 --> 00:12:42,170
+وصفات ليس لها ضد الصفات المتضادة إيش يا أخوات؟
+
+151
+00:12:42,170 --> 00:12:46,630
+يعني الصفة وضدها وعكسها وهذه الصفات المتضادة
+
+152
+00:12:46,630 --> 00:12:50,230
+تتقاسم حروف اللغة العربية يعني حروف اللغة العربية
+
+153
+00:12:50,230 --> 00:12:53,050
+تمانية وعشرين حرف أو واحد و تلاتين حرف بالنسبة لو
+
+154
+00:12:53,050 --> 00:12:57,890
+أضافنا لها الحروف المد تتقاسمها يأمل تكون كذا إذا
+
+155
+00:12:57,890 --> 00:13:01,690
+لم تكن في الشدة كانت في الرخاء وإذا لم تكن في
+
+156
+00:13:01,690 --> 00:13:05,550
+الهمس بتكون في الجهر و هكذاإذا في عندنا صفات
+
+157
+00:13:05,550 --> 00:13:11,770
+متضادة و هي الهمسو أو الجهرق و ضده الهمس الشدة و
+
+158
+00:13:11,770 --> 00:13:15,490
+ضدها الرخاوة و بينها هو التوسط الاستعلاء و ضده
+
+159
+00:13:15,490 --> 00:13:20,150
+الاستفال الإطباق و ضده الانفتاح الإذلاق و ضده
+
+160
+00:13:20,150 --> 00:13:25,370
+الإصباط كام صفة صرنا ماخدين؟11 صفة يعني خمس صفات
+
+161
+00:13:25,370 --> 00:13:30,110
+متضهضة وفي عندنا التوسط صفة رقم 11 وفي عندنا صفات
+
+162
+00:13:30,110 --> 00:13:34,730
+أخوات ليست لها ضد يعني صفة لوحدها لها حروف معينة
+
+163
+00:13:34,730 --> 00:13:38,890
+هذه الصفات اللتي ليست لها ضد ان هي الصفير والقلقلة
+
+164
+00:13:38,890 --> 00:13:44,890
+واللين والانحراف والتكرير والتفشي والاسطالة والغنى
+
+165
+00:13:44,890 --> 00:13:48,790
+والغفاء مجموعة هذه الصفات اللتي سوف ندرسها كام صفة
+
+166
+00:13:48,790 --> 00:13:54,520
+يا أخوات؟هي تسعى بصفات يعني ليست لها ضد ومع الصفات
+
+167
+00:13:54,520 --> 00:14:00,020
+اللي متضادة عشرون صفة نبدأ الآن بالشرح التفصيلي
+
+168
+00:14:00,020 --> 00:14:04,980
+لهذه الصفات أول صفة عندنا يا أخوات ما هي صفة الهمس
+
+169
+00:14:04,980 --> 00:14:10,500
+ما معنى الهمس يعني واحد يهمس همسا يعني يتكلم كلام
+
+170
+00:14:10,500 --> 00:14:16,920
+خافي إذا الهمس لغة الخفاء وفي الإصطلاح من يعرف أن
+
+171
+00:14:16,920 --> 00:14:17,620
+أنا الهمس تفضلي
+
+172
+00:14:22,790 --> 00:14:27,930
+أحسنتي جريان النفس في المخرج عند النطق بحرف الهمس
+
+173
+00:14:27,930 --> 00:14:32,570
+لضعف اعتماد الحرف على مخرجه يعني الأثناء النطق
+
+174
+00:14:32,570 --> 00:14:37,610
+بالحرف نجد أن ال .. ال .. الريح أو النفس يجري نقول
+
+175
+00:14:37,610 --> 00:14:43,230
+مثلا ها اف .. اف .. اف .. في ريح ولا مافي ريح؟ في
+
+176
+00:14:43,230 --> 00:14:50,410
+نفس كذلك غير عن ال اب .. اب في نفس ال اط .. اط ..
+
+177
+00:14:50,410 --> 00:14:54,120
+فاش نفس ال اط .. اط ..لا يوجد .. لا يوجد نفس، لكن
+
+178
+00:14:54,120 --> 00:15:01,620
+ال .. ال .. اللي هي حروفه حثه شخص فسكت، يعني عشر
+
+179
+00:15:01,620 --> 00:15:07,060
+حروف، حثه شخص فسكت، عشر حروف، هذه حروف نسميها حروف
+
+180
+00:15:07,060 --> 00:15:12,600
+الهمس، إذا من يعرف لنا الهمس؟ هو؟ فضليه؟ هو جريان
+
+181
+00:15:12,600 --> 00:15:15,280
+النفس في المخرج عند نطق حرف الهمس لضعف اعتماد
+
+182
+00:15:15,280 --> 00:15:20,630
+الحرف على مخرجه وما هو .. وما هي حروفه؟ فضليه؟حتى
+
+183
+00:15:20,630 --> 00:15:26,590
+وشخص فسكت كام حرف عشرة حروف كام بقية من الحروف
+
+184
+00:15:26,590 --> 00:15:31,210
+باقية حروف اللغة العربية اللي هي ماتسمت بحروف إيش
+
+185
+00:15:31,210 --> 00:15:36,210
+بحروف الجهر وهي واحد وعشرين حرف لو اعتبرنا أن حروف
+
+186
+00:15:36,210 --> 00:15:40,490
+اللغة العربية واحد وتلاتين حرف عشرة حروف الهمس حتى
+
+187
+00:15:40,490 --> 00:15:43,650
+وشخص فسكت باقي الحروف اللي هي واحد وعشرين حرف
+
+188
+00:15:43,650 --> 00:15:51,700
+نسميها حروف إيش حروف الجهر والجهر لغة إيهالظهور
+
+189
+00:15:51,700 --> 00:15:55,960
+والإعلان، جهرية الدعوة، يعني أو جهرة بالدعوة بمعنى
+
+190
+00:15:55,960 --> 00:16:01,020
+أظهرها، أظهرت الشيء بمعنى أعلنته وبينته، إذا الجهر
+
+191
+00:16:01,020 --> 00:16:05,840
+هو الظهور والإعلان وفي الإصطلاح، ما هو تعريفه في
+
+192
+00:16:05,840 --> 00:16:09,420
+الإصطلاح؟ فضل أختي هي انحفاز النفس في المغرج عند
+
+193
+00:16:09,420 --> 00:16:15,990
+نطق بحرف الجهرأحسنتِ إذا هناك قلنا في الهمس جريان
+
+194
+00:16:15,990 --> 00:16:20,970
+النفس في المخرج عند النطق بحرف الهمس لضعف اعتماد
+
+195
+00:16:20,970 --> 00:16:26,630
+الحرف على مخرجه هنا عكسه إن انحباس النفس في المخرج
+
+196
+00:16:26,630 --> 00:16:31,170
+عند النطق بحرف الجهر لقوة اعتماد الحرف على مخرجه
+
+197
+00:16:31,170 --> 00:16:36,610
+عندما ننطق بحرف الجهر نجد أن النفس يحبس مثل مثال
+
+198
+00:16:36,610 --> 00:16:46,920
+ذلكانحبس النفس، كويس؟ إب إد طط اطط اج مناجد أن
+
+199
+00:16:46,920 --> 00:16:51,140
+النفس يحبس في هذه الحروف إذا انحباس النفس في
+
+200
+00:16:51,140 --> 00:16:55,940
+المخرج عند النط بحرف الجهر لقوة اعتماد الحرف على
+
+201
+00:16:55,940 --> 00:17:01,260
+مخرجه وحروف الجهر ما هي؟باقي حروف اللغة العربية او
+
+202
+00:17:01,260 --> 00:17:07,260
+نقول المجموعة في قوله ايش عظمة وزنقارق غضن ذي طلب
+
+203
+00:17:07,260 --> 00:17:13,600
+جد ما معناه يا أخوات عظمة وزنقارق غضن ذي طلب جد هل
+
+204
+00:17:13,600 --> 00:17:19,170
+المراد معرفة الجملة تكون لها معنىيعني الغرب من
+
+205
+00:17:19,170 --> 00:17:23,310
+إيجاد مثل هذه الكلمات مثل كلمة أخي هاكا علما حازا
+
+206
+00:17:23,310 --> 00:17:29,070
+وغيره خاسره يرملون ينمو كذلك اللي هي عظمه وازنقار
+
+207
+00:17:29,070 --> 00:17:33,210
+انغضن ذي طلب جد حثه وشخص فسكت هذه كلها عبارة عن
+
+208
+00:17:33,210 --> 00:17:38,480
+محاولة لجمع الحروف المطلوبة في جملةأو في بيت شعير
+
+209
+00:17:38,480 --> 00:17:44,820
+أو في كلمة حتى يسهل علينا حفظها لذلك أنا أقول هي
+
+210
+00:17:44,820 --> 00:17:50,160
+غير مطلوب المعنى لكن ممكن أن يكون لها معنى ما هو
+
+211
+00:17:50,160 --> 00:17:57,280
+معناها عظمة وزن قارئ غضل ذي طلب جد؟يعني عظمة منزلة
+
+212
+00:17:57,280 --> 00:18:01,880
+القارئ الغضب ما معنى القارئ الغضب الصغير ذي طلب جد
+
+213
+00:18:01,880 --> 00:18:07,380
+الذي يجتهد في طلب العلم عظمة وزن قارئ غضب ذي طلب
+
+214
+00:18:07,380 --> 00:18:12,100
+جد عظمة منزلة القارئ الصغير ذي طلب جد يعني لو كان
+
+215
+00:18:12,100 --> 00:18:18,060
+مثلا عندنا ولد صغير حافظ القرآن وشيخ كبير غير حافظ
+
+216
+00:18:18,060 --> 00:18:24,160
+شيء من القرآن وارد أن نوقف إمامامن سيقف أمام يأمر
+
+217
+00:18:24,160 --> 00:18:29,200
+القوم أقراهم لكتاب الهافظ، إذا عظم منزلة هذا الولد
+
+218
+00:18:29,200 --> 00:18:33,820
+الصغير الغد لأنه يحفظ القرآن، إذا عظم وزن قارئ غد
+
+219
+00:18:33,820 --> 00:18:40,360
+ذي طلب جد، هذا بالنسبة للجهروحروفه واحد وعشرين حرف
+
+220
+00:18:40,360 --> 00:18:44,640
+الآن صفة الجهر يا أخوات وكمان صفة الهمس كلاهما
+
+221
+00:18:44,640 --> 00:18:49,740
+بتثبتوا للحرف في حالة العركة أو السكون واصلا ووقفا
+
+222
+00:18:49,740 --> 00:18:55,460
+يعني في كل أحواله لو جينا بالحرف ساكن مثل البروج
+
+223
+00:18:55,460 --> 00:19:02,620
+فيه إيش يعني جهر انفطرت فيه همس مثلا يعني بحيث لو
+
+224
+00:19:02,620 --> 00:19:09,670
+كانت الحرفالهمس أو الجهر ساكن أو متحرك موقوف عليه
+
+225
+00:19:09,670 --> 00:19:13,790
+أو موصول بتظهر عليه صفة الجهر أو بتظهر عليه صفة
+
+226
+00:19:13,790 --> 00:19:18,270
+الهمس لو كان هو من حروف الهمس صفة الهمس يا أخوات
+
+227
+00:19:18,270 --> 00:19:24,890
+هل هي صفة قوة ولا صفة ضعف؟الهمس صفة ضاف أما الجهر
+
+228
+00:19:24,890 --> 00:19:31,010
+ضدها صفة قوة وصفة الهمس والجهر صفتان متضادتان
+
+229
+00:19:31,010 --> 00:19:35,910
+وكلاهما تتنازعان حروف اللغة العربية يعني بتتقاسم
+
+230
+00:19:35,910 --> 00:19:40,590
+حروف اللغة العربية هل يمكن أن يكون الحرف موجود في
+
+231
+00:19:40,590 --> 00:19:45,240
+الهمس وفي نفس الوجد موجود في الجهر؟لأ إما أن يكون
+
+232
+00:19:45,240 --> 00:19:49,920
+الحرف في همس وإما أن يكون في الجهر لذلك نقول أن
+
+233
+00:19:49,920 --> 00:19:55,120
+حروف الهمس حثه شخص فسكت وحروف الجهر باقي حروف
+
+234
+00:19:55,120 --> 00:19:59,360
+اللغة العربية ولا يمكن أن يكون الحرف فيه صفة الهمس
+
+235
+00:19:59,360 --> 00:20:05,460
+وصفة الضعف ولكن كل حرف أقل شيء هيكون فيه خمس صفات
+
+236
+00:20:05,460 --> 00:20:10,740
+هنا عندنا كام صفة يا بنات؟عشرون صفة كل حرف من حروف
+
+237
+00:20:10,740 --> 00:20:13,820
+أقل شيء هيكون فيه خمس صفات اللي هي الخمس صفات
+
+238
+00:20:13,820 --> 00:20:18,340
+المتضاعفة أقل شيء لكن ممكن يكون فيه ست صفات وممكن
+
+239
+00:20:18,340 --> 00:20:24,440
+يكون سبع صفات مع بعضها البعض ونستطيع أن نميز ما
+
+240
+00:20:24,440 --> 00:20:29,600
+بين الحرف القوي والضعيف من وجود الصفات القوة أو
+
+241
+00:20:29,600 --> 00:20:34,300
+الصفات الضعف في هذا الحرفخلصنا يا أخوات الصفة
+
+242
+00:20:34,300 --> 00:20:40,180
+الأولى المتضادة و ضدها همس و ضده الجهر الهمس صفة
+
+243
+00:20:40,180 --> 00:20:44,800
+ضعف الجهر صفات قوة الهمس حروفه حتى و شخص فسكت
+
+244
+00:20:44,800 --> 00:20:49,360
+الجهر باقي حروف اللغة العربية أو أن نقول هي حروف
+
+245
+00:20:49,360 --> 00:20:54,020
+عظمة و نقارن غضن دي طالب جد الصفات الصفات الهمس و
+
+246
+00:20:54,020 --> 00:20:57,280
+الجهر ممكن تكون ملازمة للحرف في حد السكون عندما
+
+247
+00:20:57,280 --> 00:21:02,220
+يكون ساكن أو متحرك ولكن يكون يعني أقل أو في وسط
+
+248
+00:21:02,220 --> 00:21:08,140
+الكلمةيعني موصول أو موقوف عليهم الصفة الثانية يا
+
+249
+00:21:08,140 --> 00:21:13,440
+أخوات اللي هي صفة الشدة و ضدها الرخاوة و بين الشدة
+
+250
+00:21:13,440 --> 00:21:19,190
+والرخاوة التوسط ما معنى الشدة يا أخوات؟فلان شديد
+
+251
+00:21:19,190 --> 00:21:23,810
+يعني إيه؟ قوة والحرف الشديد يعني قوة والشدة في
+
+252
+00:21:23,810 --> 00:21:28,910
+الإصطلاح انحباس الصوت في المخرج عند النطق بحرف
+
+253
+00:21:28,910 --> 00:21:33,010
+الشدة لقوة اعتماد الحرفي على مخرجه يعني بيشبه
+
+254
+00:21:33,010 --> 00:21:38,290
+تماما اللي هو الهمس والجهر يعني بيشبه الجهر هناك
+
+255
+00:21:38,290 --> 00:21:45,060
+بيقول انحباس النفسفي المخرج هنا نقول انحباس الصوت
+
+256
+00:21:45,060 --> 00:21:50,020
+في المخرج عند النطق بحرف الشدة ليش لقوة اعتماد
+
+257
+00:21:50,020 --> 00:21:53,700
+الحرف على المخرج اما نجد ان الحرف يعتمد اعتماد
+
+258
+00:21:53,700 --> 00:21:59,460
+كامل على المخرج انا عندما اقول مثلا لا يعتمد لان
+
+259
+00:21:59,460 --> 00:22:04,760
+في نفس بيجري و في نريح بمشي لكن عندما اقول اب
+
+260
+00:22:08,150 --> 00:22:13,430
+المخرج بيعتمد وبيلتزق الاتصالات لدرجة أنه يمنع
+
+261
+00:22:13,430 --> 00:22:18,710
+جريان النفس وجريان الصوت لا في صوت ولا في نفس فإذا
+
+262
+00:22:18,710 --> 00:22:22,470
+فتح المخرج ايب تخرج معاه نبرة ومن سميها القلقلة
+
+263
+00:22:22,470 --> 00:22:27,710
+عندما أقول ابانحبس النفس وانحبس المخرج وممكن يا
+
+264
+00:22:27,710 --> 00:22:32,570
+أخوات اللي هو الحرف فيه صفة الهمس وصفة الرخاوة أو
+
+265
+00:22:32,570 --> 00:22:36,390
+فيه صفات متضادة لأنه قلنا أن أقل شيء في الحرف لابد
+
+266
+00:22:36,390 --> 00:22:42,430
+أن يكون فيه خمس صفات عرفنا صفة الشدة انحباس الصوت
+
+267
+00:22:42,430 --> 00:22:46,770
+في المخرج عند النطق بحرف الشدة لقوة اعتماد الحرفي
+
+268
+00:22:46,770 --> 00:22:52,240
+على الأخرجين ما هي حروف الشدة يا أخوات؟حروف الشدة
+
+269
+00:22:52,240 --> 00:22:58,000
+أجد قط بكت أجد قط بكت اللي هي كام حرف؟ تمان حروف
+
+270
+00:22:58,000 --> 00:23:02,740
+أجد قط بكت تمان حروف إيش معناها؟ ممكن مايكونش ليها
+
+271
+00:23:02,740 --> 00:23:06,440
+معنى لكن بدنا نعرف اللي هي الهمزة والجيم والدال
+
+272
+00:23:06,440 --> 00:23:11,060
+والقاف والطا والبا والكاف والتا صفة الشدة يا أخوات
+
+273
+00:23:11,060 --> 00:23:17,090
+هل هي صفة قوة ولا صفة ضعف؟من كلمة شدة يبقى معناها
+
+274
+00:23:17,090 --> 00:23:22,570
+طوية ومن كلمة رخامة و هي ضدها تعد ضعيفة إذا هذه
+
+275
+00:23:22,570 --> 00:23:27,390
+صفة الشدة وتثبت صفة الشدة يا أخوات في جميع أحوالها
+
+276
+00:23:27,390 --> 00:23:31,830
+سواء كانت الأحرف ساكنة أو متحركة وسط الكلام أم
+
+277
+00:23:31,830 --> 00:23:36,250
+آخره إلا أنها بتكون أوضح شيء الشدة موجودة في الحرف
+
+278
+00:23:36,250 --> 00:23:46,260
+الساكن مثال ذلك اد اب اج اط اط و هكذاالصفة الثانية
+
+279
+00:23:46,260 --> 00:23:52,720
+طبعا ضدها الرخاوة وما بين الشدة والرخاوة التوسط
+
+280
+00:23:52,720 --> 00:23:57,060
+فما معنى التوسط؟ طبعا خيره الأمور ايه؟ اوسطها
+
+281
+00:23:57,060 --> 00:24:02,720
+والتوسط هي صفة الاعتدال هي صفة معتادة ما بين الشدة
+
+282
+00:24:02,720 --> 00:24:07,500
+والرخاوة يعني لغة الاعتدال وفي الاصطلاح اعتدال
+
+283
+00:24:07,500 --> 00:24:13,040
+الصوت في المخرج عند نثق بحرف التوسط لعدم كمال
+
+284
+00:24:13,040 --> 00:24:18,330
+حباسي فيهلا نقول جريان الصوت ولا نقول انحباس الصوت
+
+285
+00:24:18,330 --> 00:24:22,870
+هو اعتدال الصوت في المخرج عند النطق بحرف التوسط
+
+286
+00:24:22,870 --> 00:24:27,830
+لعدم كمال انحباسه فيه يعني بتلاقي الصوت بيجري
+
+287
+00:24:27,830 --> 00:24:33,790
+بيمشي معناه وحروف التوسط خمسة مجموعة في قوله لن
+
+288
+00:24:33,790 --> 00:24:39,390
+عمر يعني معناه لن فعل أمر يعني كون لينا يا عمر لن
+
+289
+00:24:39,390 --> 00:24:44,970
+عمرلأن عمر يعني عندما أقول أنا ال .. ال .. يعني في
+
+290
+00:24:44,970 --> 00:24:49,430
+صوت لكن مش .. مش زي ال .. ب .. لأ هو عدم كمال
+
+291
+00:24:49,430 --> 00:24:52,950
+الحباس فيه يعني جريان الصوت .. يعني اعتدال الصوت
+
+292
+00:24:52,950 --> 00:24:56,630
+في المخرج عند النطق بحرف التوسط لعدم كمال الحباس
+
+293
+00:24:56,630 --> 00:25:01,450
+فيه فانا عندما أقول ال .. في صوت لكن برضه النفس
+
+294
+00:25:01,450 --> 00:25:09,640
+بمش معاه كذلك in ..A M R فيه صوت وفيه جريان النفس
+
+295
+00:25:09,640 --> 00:25:14,420
+لذلك لعدم كمال الحباس فيه فالمخرج لا يعتمد اعتمادا
+
+296
+00:25:14,420 --> 00:25:19,240
+كاملا على مخرجه بل في صوت ولكن بيسمح كمان بجريان
+
+297
+00:25:19,240 --> 00:25:23,780
+النفس فنقول هو اعتدال الصوت في المخرج عند النطق
+
+298
+00:25:23,780 --> 00:25:28,860
+بحرف التوسط ليش؟ لعدم كمال الحباس فيه وحروفه خمسة
+
+299
+00:25:29,230 --> 00:25:33,130
+مجموعة في قوله لين عمر يعني لكون لينا يا عمر
+
+300
+00:25:33,130 --> 00:25:38,510
+وبتثبت صفة التوسط في جميع أحوال الحرف سواء كان
+
+301
+00:25:38,510 --> 00:25:44,950
+ساكن ولا متحرك وموقوف عليه ولا يعني مقصود وصفة
+
+302
+00:25:44,950 --> 00:25:50,410
+التوسط يا أخوات هل هي صفة قوة ولا صفة ضعف؟صفة
+
+303
+00:25:50,410 --> 00:25:53,710
+اعتدال ما احنا قولنا اعتدال الصوت في المخرج هذا لا
+
+304
+00:25:53,710 --> 00:25:59,230
+هي قوية ولا هي ضعيفة بل هي معتدلة وخير الأمور
+
+305
+00:25:59,230 --> 00:26:04,350
+أوسطها وعندما نحسب الحروف هل هي قوية ولا ضعيفة صفة
+
+306
+00:26:04,350 --> 00:26:07,770
+الاعتدال لاتنحسبش يعني والله التوسط يعني مش محسوبة
+
+307
+00:26:07,770 --> 00:26:12,610
+لا مع القوية ولا مع الضعيفة بيكونوا على الحينطيب
+
+308
+00:26:12,610 --> 00:26:19,030
+ضد التوسط ضد الشدة في عندنا الرخاوة عندنا الشدة و
+
+309
+00:26:19,030 --> 00:26:23,670
+ضدها الرخاوة الشدة انحباس الصوت و الرخاوة جريان
+
+310
+00:26:23,670 --> 00:26:29,030
+الصوت في المخرج عند نطنه بحرف الرخاوة لضعف اعتماد
+
+311
+00:26:29,030 --> 00:26:33,210
+الحرف على مخرجه جريان الصوت في المخرج عند نطنه
+
+312
+00:26:33,210 --> 00:26:37,800
+بحرف الرخاوة لضعف اعتماد الحرف على مخرجهوصفة
+
+313
+00:26:37,800 --> 00:26:42,860
+الرخاوة يا اخوات يعني حروفها باقي حروف اللغة
+
+314
+00:26:42,860 --> 00:26:48,900
+العربية يعني في عندنا اشد قطبكة تمان حروفو لين عمر
+
+315
+00:26:48,900 --> 00:26:53,820
+خمس حروف هيسار و تلتاش باقي حروف اللغة العربية هي
+
+316
+00:26:53,820 --> 00:26:58,540
+حروف الرخامة يعني عندنا ننظر إلى الحرف إذا لم يكن
+
+317
+00:26:58,540 --> 00:27:03,520
+من أجد قط بكت اللي هي حروف الشدة ولم يكن من حروف
+
+318
+00:27:03,520 --> 00:27:07,080
+لين عمر اللي هي حروف التوسط مباشرة هنقول صفته إيه؟
+
+319
+00:27:07,460 --> 00:27:12,500
+صفة رخاوة، إذا حروف الرخاوة هي باقي حروف اللغة
+
+320
+00:27:12,500 --> 00:27:16,080
+العربية و هذه الصفات كلها متضادة و تثبت صفة
+
+321
+00:27:16,080 --> 00:27:19,440
+الرخاوة يا أخوات في جميع أحوالها، يعني في الساكن و
+
+322
+00:27:19,440 --> 00:27:24,320
+المتحرك و الموصول و الموقوف بالنسبة لهذا الحرف صفة
+
+323
+00:27:24,320 --> 00:27:29,140
+الرخاوة صفة قوة ولا ضعف يا أخوات؟ صفة ضعف، إذا كام
+
+324
+00:27:29,140 --> 00:27:35,540
+صفة صفتنا ماخديني الآن؟hams و ضده الجهر شدة و ضدها
+
+325
+00:27:35,540 --> 00:27:40,740
+الرخاوة و بينهما التوسط خمس صفات الhams صفة ضعف و
+
+326
+00:27:40,740 --> 00:27:48,200
+ضده الجهر صفة قوة الشدة صفة قوة و ضدها الرخاوة صفة
+
+327
+00:27:48,200 --> 00:27:54,160
+ضعف و في عندنا صفة التوسط صفة معتدلة لا محسوبة لا
+
+328
+00:27:54,160 --> 00:27:58,850
+مع الشدة ولا مع الجهرالصفة اللي بديه بعدها من
+
+329
+00:27:58,850 --> 00:28:04,030
+الصفات المتضادة الاستعلاء صفة الاستعلاء وضده صفة
+
+330
+00:28:04,030 --> 00:28:08,470
+ايش يا أخوات صفة الاستفال والاستعلاء من العلوي
+
+331
+00:28:08,470 --> 00:28:13,190
+والارتفاع فلان مستعلي او اعتلى او مبانا ارتفعة
+
+332
+00:28:13,190 --> 00:28:18,830
+وعلى وفي الاصطلاح هو ارتفاع أقصى اللسان إلى الحنك
+
+333
+00:28:18,830 --> 00:28:23,670
+الأعلى عند النطق بحرف الاستعلاء لقوة اعتماد حرف
+
+334
+00:28:23,670 --> 00:28:28,260
+على مخرجهارتفاع الأقصى اللسان إلى الحناك الأعلى
+
+335
+00:28:28,260 --> 00:28:33,380
+عند النطن بحرف الاستعلاء وحروف الاستعلاء هي سبعة
+
+336
+00:28:33,380 --> 00:28:39,060
+مجموعة في قوله خصة تنقر وهذه طبعا بترتب عليها
+
+337
+00:28:39,060 --> 00:28:43,080
+معرفة الحروف التي تفخم والحروف التي ترقق يعني
+
+338
+00:28:43,080 --> 00:28:46,220
+بيعتمد عليها اللي هي التفهيم والترقيقة اللي سوف
+
+339
+00:28:46,220 --> 00:28:50,760
+ناخده ان شاء الله تعالى يعني في الدروس القادمة هذه
+
+340
+00:28:50,760 --> 00:28:55,010
+صفة الاستعلاء كام حرف صفة الاستعلاء يا أخوات؟سبة
+
+341
+00:28:55,010 --> 00:28:59,410
+حروف مجموعة في قوله خُص ضغط قض و تثبت صفة
+
+342
+00:28:59,410 --> 00:29:03,330
+الاستعلاء كذلك في جميع أحوالها يعني الحرف لو كان
+
+343
+00:29:03,330 --> 00:29:11,490
+متوسطا او متطرفا موصولا او موقوفا متحركا او ساكنا
+
+344
+00:29:11,490 --> 00:29:15,870
+في جميع أحواله بتلاقي ملزن فيه لأن هذه الصفات
+
+345
+00:29:15,870 --> 00:29:21,350
+اللتي ندرسها هي صفات ملازمة لازمة ولا صفات عرضية
+
+346
+00:29:21,800 --> 00:29:25,900
+لازم، إذا ملسق في الحرف، ملازم للحرف في جميع
+
+347
+00:29:25,900 --> 00:29:31,200
+أحواله، سواء كان فيه متوسطا ولا متطرفا، موصولا ولا
+
+348
+00:29:31,200 --> 00:29:36,880
+موقوفا، ساكنا ولا متحركا، فصفة الاستعلاء صفة لازمة
+
+349
+00:29:36,880 --> 00:29:41,680
+للحرف، وصفة الاستعلاء يا أخوات صفة قوة ولا صفة ضعف
+
+350
+00:29:43,030 --> 00:29:47,430
+أه صفة قوة و ضد الاستعلاء صفة ايش الاستفال
+
+351
+00:29:47,430 --> 00:29:52,030
+الاستفال ضده ضد الاستعلاء والاستفال يا اخوات يعني
+
+352
+00:29:52,030 --> 00:29:57,350
+هو من معناته الانخفاض والانحطاف والاستفال اصطلاحا
+
+353
+00:29:57,350 --> 00:30:01,710
+انخفاض أقصى اللسان عن الحنك الأعلى إلى قاع الفمي
+
+354
+00:30:01,710 --> 00:30:06,180
+عند النطق بحرف الاستفال يعني زي ما قلنافي
+
+355
+00:30:06,180 --> 00:30:10,640
+الاستعلاء ارتفاع اللسان إلى الحنك الأعلى عند النطق
+
+356
+00:30:10,640 --> 00:30:15,940
+بحرف الاستعلاء نقول الاستفال عكسه مش ارتفاع هو
+
+357
+00:30:15,940 --> 00:30:20,440
+انخفاض اللسان إلى قاع الفمي عند النطق بحرف
+
+358
+00:30:20,440 --> 00:30:26,270
+الاستفال وحروف الاستفال ما هي؟باقي حروف اللغة
+
+359
+00:30:26,270 --> 00:30:30,550
+العربية و طبعا احنا قلنا ايضا تثبت صفة الاستفال
+
+360
+00:30:30,550 --> 00:30:36,090
+للحرف جميع أحواله و حروف الاستفال هل هي صفة قوة
+
+361
+00:30:36,090 --> 00:30:41,950
+ولا صفة ضعف؟صفات ضعيفة مثال و ذلك مثلا كلمة باطل
+
+362
+00:30:41,950 --> 00:30:49,430
+تائب سائب سائل حرف الصين هذا عبارة عن حروف استفال
+
+363
+00:30:49,430 --> 00:30:56,750
+وهي مرققة فلبد أن تكون يعني نخرجها و بتكون صفتها
+
+364
+00:30:56,750 --> 00:31:02,810
+صفات ضعيفةفي عندنا كمان صفة الإطباق و ضده
+
+365
+00:31:02,810 --> 00:31:07,490
+الاستعلاء صفة الإطباق و ضده الاستعلاء طبعا الإطباق
+
+366
+00:31:07,490 --> 00:31:12,290
+مانته إيش يا أخوات أطبقت
+
+367
+00:31:12,290 --> 00:31:15,810
+الشاي بمعنى ألسقته إذا الإطباق من حيث اللغة
+
+368
+00:31:15,810 --> 00:31:20,430
+الإلساق و في الإصطلاح إلتساق طائفة من اللسان
+
+369
+00:31:20,430 --> 00:31:26,150
+بالحنك الأعلى عند النطق بحرف الإطباق فينحصر الصوت
+
+370
+00:31:26,150 --> 00:31:32,220
+بينهمالاتصاق طائفة من اللسان، بنلاقي طائفة من
+
+371
+00:31:32,220 --> 00:31:36,340
+اللسان سواء كان وسطه ولا أقصى اللسان، بيلتسق
+
+372
+00:31:36,340 --> 00:31:40,440
+بالحنك الأعلى التصاقا، فيمنع الصوت وبيمنع النفس
+
+373
+00:31:40,440 --> 00:31:47,700
+وله قوة، فبنسمي هذا استعلاء، إذا الإطباق هو التصاق
+
+374
+00:31:47,700 --> 00:31:51,940
+طائفة من اللسان بالحنك الأعلى عند النطق بحرف
+
+375
+00:31:51,940 --> 00:31:56,320
+الإطباق فينحصر الصوت بينهما، لكن ما هي حروف
+
+376
+00:31:56,320 --> 00:32:04,030
+الإطباق؟حروف الأطباق أربعة حروف اللي هي الأط والأض
+
+377
+00:32:04,030 --> 00:32:09,910
+والأص والأض من حيث القوة يعني أول أقوى شئ حرف الأط
+
+378
+00:32:09,910 --> 00:32:15,310
+بيلاقي أط ببيتفع اللسان إلى اللحنك الأعلى وبيلتسف
+
+379
+00:32:15,310 --> 00:32:22,510
+وجميع صفات حرف الأط ب هو صفات قوة يليه الأضالأض
+
+380
+00:32:22,510 --> 00:32:26,590
+حرف الأض اللي بيخرج من إحدى حرفتان اللسان اليمنى
+
+381
+00:32:26,590 --> 00:32:30,610
+أو اليسرة مع ما يريه من أضلاص الجهة العلية بيخرج
+
+382
+00:32:30,610 --> 00:32:37,170
+منه حرف الضال فيأتي بالترتيب بعده ثم الأص ثم الأض
+
+383
+00:32:37,170 --> 00:32:41,370
+من حيث القوة وكلها تسمى حروف الأطباق الحروف
+
+384
+00:32:41,370 --> 00:32:46,730
+الأطباق الأط والأض والأص والأض وهي مرتبة على هذا
+
+385
+00:32:46,730 --> 00:32:48,570
+الحال مثل الط
+
+386
+00:32:59,490 --> 00:33:05,410
+و تثبت طبعا صفة الإطباق لحرف جميع أحواله و صفة
+
+387
+00:33:05,410 --> 00:33:11,410
+الإطباق صفة قوة و الإطباق أخصه من الاستعلام ليش يا
+
+388
+00:33:11,410 --> 00:33:16,070
+أخوة الإطباق أخصه من الاستعلام الاستعناء حروفه خُص
+
+389
+00:33:16,070 --> 00:33:22,060
+صداق انقذ سبب حروفالاطباق موجودة في حروف الاستعلاء
+
+390
+00:33:22,060 --> 00:33:25,740
+اللي هي الصاد والضاد والطا والظهر جزء من حروف
+
+391
+00:33:25,740 --> 00:33:31,280
+الاستعلاء لذلك اخصه من الاستعلاء فكل حرف من حروف
+
+392
+00:33:31,280 --> 00:33:37,520
+الاطباق هو استعلاءوليس العكس وليس كل استعلاء إطباق
+
+393
+00:33:37,520 --> 00:33:43,280
+لأن هناك بعض الحروف حرف الخ وغيره و القاف لا تعد
+
+394
+00:33:43,280 --> 00:33:48,700
+من حروف الإطباق وصفة الإطباق كما قلنا هي صفة قوة
+
+395
+00:33:48,700 --> 00:33:53,860
+وضدها صفة إيش يا أخوات صفة الانفتاح والانفتاح ضد
+
+396
+00:33:53,860 --> 00:33:58,340
+الإطباق ومعنى الانفتاح هو الافتراكالاطباق هو
+
+397
+00:33:58,340 --> 00:34:03,160
+الاتصاق طائفة من اللسان بالحלק الأعلى هنا الانفتاح
+
+398
+00:34:03,160 --> 00:34:08,120
+افتراق طائفة او افتراق اللسان عن الحלק الأعلى عند
+
+399
+00:34:08,120 --> 00:34:13,480
+النطق بحرف الانفتاح فلا ينحصر الصوت بينهما وحروف
+
+400
+00:34:13,480 --> 00:34:18,500
+الانفتاح يا أخوات هي باقي حروف اللغة العربية
+
+401
+00:34:18,500 --> 00:34:25,580
+والأمثل على ذلك كثيرة ومتعددة مثل حنيدمجيد خاسرون
+
+402
+00:34:25,580 --> 00:34:31,160
+فكل ال ح وال ج و الصين كل هذه حروف انفتاح ولا
+
+403
+00:34:31,160 --> 00:34:35,660
+تعدوا من حروف الإطباع حروف الانفتاح كذا يا أخوات
+
+404
+00:34:35,660 --> 00:34:40,720
+أعموا من الاستفال يعني حروف الانفتاح أكثر الاستفال
+
+405
+00:34:40,720 --> 00:34:46,260
+أقل يعني كل استفال هو انفتاح وليس كل حرف من حروف
+
+406
+00:34:46,260 --> 00:34:47,980
+الانفتاح استفال
+
+407
+00:34:49,920 --> 00:34:54,040
+آخر صفتين متضادتين يا أخوات هي صفة الإذلاق و ضده
+
+408
+00:34:54,040 --> 00:34:58,840
+الإصناق والإذلاق معناه هو الفصاحة والبلاغة والخفة
+
+409
+00:34:58,840 --> 00:35:03,040
+نقول فلان ذلق اللسان يعني الكلام والشعر أو اللي
+
+410
+00:35:03,040 --> 00:35:08,620
+ينساقه من اللسان بسهولة بل إنسان بليغكلامه جميل
+
+411
+00:35:08,620 --> 00:35:14,600
+يعني زي أديب أو شاعر اسمه ذلق اللسان إذا من حياته
+
+412
+00:35:14,600 --> 00:35:19,120
+اللغة الإذلاق لغة الفصاحة والبلاغة والخفة وفي
+
+413
+00:35:19,120 --> 00:35:24,480
+الاصطلاح هو خفة الحرفي وسرعة النطق به لخروجه من
+
+414
+00:35:24,480 --> 00:35:29,920
+ذلق اللساني أو الشفة أو الشفتيمانإذا الإذلاق هو
+
+415
+00:35:29,920 --> 00:35:35,420
+خفة الحرفي و سرعة الإنطلاق به لخروجه من ذلق اللسان
+
+416
+00:35:35,420 --> 00:35:39,640
+إيش يعني ذلق اللسان؟ يعني طرف اللسان أو الشفة يعني
+
+417
+00:35:39,640 --> 00:35:44,400
+الشفة الواحدة أو الشفتين معاهم لأن حروفه مجموعة في
+
+418
+00:35:44,400 --> 00:35:50,060
+قوله ثرة من لبن ما معنى أخوات ثرة من لبن؟مالهاش
+
+419
+00:35:50,060 --> 00:35:56,240
+معنى لكن اف فره الفاره ميم نون لبه يعني ست حروف
+
+420
+00:35:56,240 --> 00:36:01,940
+فره من لنبن ال و هذه الحروف بتخرج من ذلق اللساني
+
+421
+00:36:01,940 --> 00:36:06,080
+او الشفة او الشفتين معنى ذلق اللسان يعني طرف
+
+422
+00:36:06,080 --> 00:36:11,720
+اللسان اللي هو حرف اللام و الرا ال و ار تخرج من
+
+423
+00:36:11,720 --> 00:36:16,100
+طرف اللسان يعني من ذلق اللسان او الشفة يعني الشفة
+
+424
+00:36:16,100 --> 00:36:20,450
+الواحدة مثل حرف ال افمن أين يخرج حرف ال F يا
+
+425
+00:36:20,450 --> 00:36:24,250
+أخوات؟ اللي هي من بطن الشفة السفلة أو أطراف الثناء
+
+426
+00:36:24,250 --> 00:36:27,650
+العليا على بطن الشفة السفلة يعني مابنفع نقول من
+
+427
+00:36:27,650 --> 00:36:31,870
+بطن الشفة السفلة فقط لإن الواحد لو عمل هيكة بس
+
+428
+00:36:31,870 --> 00:36:36,870
+يعني و لا يتخرج حرف الفا فالنبود أن يلتقي أطراف
+
+429
+00:36:36,870 --> 00:36:40,350
+الثناء العليا على بطن الشفة السفلة فبيخرج منه حرف
+
+430
+00:36:40,350 --> 00:36:46,460
+الفاأو الشفتين معانا اللي هي ال M و ال IB إذا صفة
+
+431
+00:36:46,460 --> 00:36:51,840
+الذلاق خفة الحرفي و سرعة نطقه بيه لخروجه من ذلق
+
+432
+00:36:51,840 --> 00:36:56,940
+اللساني اللي هو ال Lam و ال .. و النون .. او ال
+
+433
+00:36:56,940 --> 00:37:02,840
+Lam و ال Ra و الشفة A اللي هي الحرف الفا و ال ..
+
+434
+00:37:02,840 --> 00:37:07,060
+أو الشفتين معانا اللي هو ال M و ال B فرة من لبن
+
+435
+00:37:08,540 --> 00:37:14,420
+لماذا يسمى ذلقي؟ لخفته وسرعته وصفة الإذلاق صفة
+
+436
+00:37:14,420 --> 00:37:21,040
+توسط وكذلك صفة الإصمات أيضا صفة توسط فالصفات
+
+437
+00:37:21,040 --> 00:37:25,860
+التوسط الأذلاق والاصمات توسط مش محسوبة على القوي
+
+438
+00:37:25,860 --> 00:37:30,900
+ولا على الضايفو كذلك التوسط مع الشدة والرخاوة و
+
+439
+00:37:30,900 --> 00:37:35,520
+بينها والتوسط لا تعد صفة قوة ولا صفة ضعف الإسماط
+
+440
+00:37:35,520 --> 00:37:39,740
+يا أخوات هي ضد الإدلاق والإسماط منع انفراد حروف
+
+441
+00:37:39,740 --> 00:37:44,560
+الإسماط في أصول الكلمات الرباعية أو الخماسية لثقة
+
+442
+00:37:44,560 --> 00:37:48,680
+لها وعدم النطق بيها لبعد مخرجها عن ذلق اللسان أو
+
+443
+00:37:48,680 --> 00:37:54,500
+الشفةيبقى معناة الإصمار منع انفراد حروف الإصمار
+
+444
+00:37:54,500 --> 00:37:59,800
+يعني لا يصح لنا أن تكون الكلمة التي هي أصل الكلمة
+
+445
+00:37:59,800 --> 00:38:04,060
+ربعية أو خماسية جميع حروفها حروف إصمار لابد أن
+
+446
+00:38:04,060 --> 00:38:08,300
+يتوفر فيها أحد حروف فر من لب عشان تكون الكلمة
+
+447
+00:38:08,300 --> 00:38:13,620
+عربيةأما إذا وردت بعض الكلمات الخماسية أو الربعية
+
+448
+00:38:13,620 --> 00:38:17,600
+أو الخماسية وجميع حروفها حروف أسماط معنى هذه أن
+
+449
+00:38:17,600 --> 00:38:23,020
+هذه الكلمة ليست عربية مثل كلمة إيش أستاذ أستاذ هي
+
+450
+00:38:23,020 --> 00:38:27,280
+كلمة فارسية وليست كلمة عربية يعني عندنا معلم لكن
+
+451
+00:38:27,280 --> 00:38:32,560
+كلمة أستاذ هي كلمة عُربت إلينا كذلك كلمة عسجد عسجد
+
+452
+00:38:32,560 --> 00:38:37,480
+معناته الذهب باللغة الفارسية عسجد معناته الذهب لكن
+
+453
+00:38:37,480 --> 00:38:42,090
+عندنا احنا اسمه ذهبو لأن كلمة عسجد رباعية و لا
+
+454
+00:38:42,090 --> 00:38:46,510
+يوجد فيها أي حرف من حروف فرة من لبن فهي إيش تصنع و
+
+455
+00:38:46,510 --> 00:38:49,910
+كذلك كلمة أستاذ لا يوجد فيها أي حرف من حروف فرة من
+
+456
+00:38:49,910 --> 00:38:54,970
+لبن إذا بتكون كلمة أستاذ كلمة ليست عربية و بهذه يا
+
+457
+00:38:54,970 --> 00:38:58,570
+أخوات منكون احنا خلصنا الجزء الأول من الصفات و هي
+
+458
+00:38:58,570 --> 00:39:02,560
+الصفات المتضادة الهمس و ضده الجهرالشدة و ضدها
+
+459
+00:39:02,560 --> 00:39:06,240
+الرخاوة و بينهم التوسط الاستعلاء و ضده الاستفال
+
+460
+00:39:06,240 --> 00:39:11,120
+الأطباق و ضده الفتاح الإذلاق و ضده الإصمات انتهينا
+
+461
+00:39:11,120 --> 00:39:13,580
+من الصفات المتضادة و ان شاء الله في المحاضرة
+
+462
+00:39:13,580 --> 00:39:17,000
+القادمة بناخد الصفات اللتي تليها و هي الصفات اللتي
+
+463
+00:39:17,000 --> 00:39:20,040
+ليس لها ضد نكتفي بهذا القدر و برك الله فيكم و
+
+464
+00:39:20,040 --> 00:39:22,000
+السلام عليكم و رحمة الله و بركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/f2WZeX9NTwQ_raw.json b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/f2WZeX9NTwQ_raw.json
new file mode 100644
index 0000000000000000000000000000000000000000..0b8c721dbf8081b5abcbfe440e89528182c557c0
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/f2WZeX9NTwQ_raw.json
@@ -0,0 +1 @@
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66.42, "end": 66.76, "word": " هو", "probability": 0.9892578125}, {"start": 66.76, "end": 67.08, "word": " الوقف", "probability": 0.994140625}, {"start": 67.08, "end": 67.54, "word": " التام", "probability": 0.79931640625}, {"start": 67.54, "end": 68.48, "word": " والثاني", "probability": 0.9080810546875}, {"start": 68.48, "end": 68.76, "word": " الوقف", "probability": 0.9767252604166666}, {"start": 68.76, "end": 69.3, "word": " الكافي", "probability": 0.966796875}], "temperature": 1.0}, {"id": 5, "seek": 9836, "start": 73.12, "end": 98.36, "text": "و أما الوقف التام طبعا هو أن يقف القارئ على كلمة القرأنية زمنا يزيرا أو أن يقف القارئ على كلمة قرأنية التي تم معناها وليس لها تعلق بما بعدها لا لفظ ولا معنى، إذا المعنى الوقف التام هو أن يقف القارئ على كلمة القرأنية تم المعنى عندها لا تتعلق بما بعدها لفظ ولا معنى", "tokens": [2407, 5551, 15042, 2423, 30543, 5172, 16712, 10943, 23032, 3555, 3615, 995, 31439, 14739, 7251, 4587, 5172, 25062, 9640, 19986, 15844, 9122, 19528, 3660, 25062, 2288, 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"end": 80.56, "word": " أن", "probability": 0.8046875}, {"start": 80.56, "end": 80.86, "word": " يقف", "probability": 0.98583984375}, {"start": 80.86, "end": 81.32, "word": " القارئ", "probability": 0.9972330729166666}, {"start": 81.32, "end": 81.7, "word": " على", "probability": 0.87060546875}, {"start": 81.7, "end": 82.02, "word": " كلمة", "probability": 0.9471028645833334}, {"start": 82.02, "end": 82.5, "word": " قرأنية", "probability": 0.91845703125}, {"start": 82.5, "end": 82.84, "word": " التي", "probability": 0.8681640625}, {"start": 82.84, "end": 83.06, "word": " تم", "probability": 0.9658203125}, {"start": 83.06, "end": 83.58, "word": " معناها", "probability": 0.8888346354166666}, {"start": 83.58, "end": 85.78, "word": " وليس", "probability": 0.613037109375}, {"start": 85.78, "end": 86.0, "word": " لها", "probability": 0.879638671875}, {"start": 86.0, "end": 86.42, "word": " تعلق", "probability": 0.8013509114583334}, {"start": 86.42, "end": 86.64, "word": " بما", "probability": 0.894775390625}, {"start": 86.64, "end": 87.0, "word": " بعدها", "probability": 0.98046875}, {"start": 87.0, "end": 87.14, "word": " لا", "probability": 0.6640625}, {"start": 87.14, "end": 87.46, "word": " لفظ", "probability": 0.8294270833333334}, {"start": 87.46, "end": 88.18, "word": " ولا", "probability": 0.455322265625}, {"start": 88.18, "end": 88.96, "word": " معنى،", "probability": 0.83721923828125}, {"start": 88.96, "end": 89.1, "word": " إذا", "probability": 0.719482421875}, {"start": 89.1, "end": 89.44, "word": " المعنى", "probability": 0.949462890625}, {"start": 89.44, "end": 89.78, "word": " الوقف", "probability": 0.9654947916666666}, {"start": 89.78, "end": 90.22, "word": " التام", "probability": 0.99072265625}, {"start": 90.22, "end": 90.84, "word": " هو", "probability": 0.97705078125}, {"start": 90.84, "end": 91.58, "word": " أن", "probability": 0.93505859375}, {"start": 91.58, "end": 91.86, "word": " يقف", "probability": 0.98828125}, {"start": 91.86, "end": 92.3, "word": " القارئ", "probability": 0.9970703125}, {"start": 92.3, "end": 92.48, "word": " على", "probability": 0.8916015625}, {"start": 92.48, "end": 92.94, "word": " كلمة", "probability": 0.9228515625}, {"start": 92.94, "end": 93.6, "word": " القرأنية", "probability": 0.9869384765625}, {"start": 93.6, "end": 93.84, "word": " تم", "probability": 0.98046875}, {"start": 93.84, "end": 94.26, "word": " المعنى", "probability": 0.9505615234375}, {"start": 94.26, "end": 94.78, "word": " عندها", "probability": 0.996337890625}, {"start": 94.78, "end": 95.26, "word": " لا", "probability": 0.62353515625}, {"start": 95.26, "end": 95.9, "word": " تتعلق", "probability": 0.9447021484375}, {"start": 95.9, "end": 96.2, "word": " بما", "probability": 0.9736328125}, {"start": 96.2, "end": 96.74, "word": " بعدها", "probability": 0.980712890625}, {"start": 96.74, "end": 97.42, "word": " لفظ", "probability": 0.9567057291666666}, {"start": 97.42, "end": 97.96, "word": " ولا", "probability": 0.970703125}, {"start": 97.96, "end": 98.36, "word": " معنى", "probability": 0.9913736979166666}], "temperature": 1.0}, {"id": 6, "seek": 12648, "start": 99.32, "end": 126.48, "text": "لو سألنا الأخوات ما المعنى بالتعلق اللفظي والتعلق المعنى؟ ما هو التعلق اللفظي يا أخوات؟ يعني كلمة لا تتعلق بما بعدها في اللفظ أو لا تتعلق بما بعدها في المعنى ما معنى التعلق اللفظ أولا؟ ممتاز، يعني التعلق اللفظي هو أن يتعلق الكلام بالموقوف بالكلام الذي بعده إعراب", "tokens": [1211, 2407, 8608, 10721, 1211, 8315, 16247, 9778, 2407, 9307, 19446, 9673, 3615, 1863, 7578, 20666, 2655, 30241, 4587, 13672, 5172, 19913, 1829, 16070, 2655, 30241, 4587, 9673, 3615, 1863, 7578, 22807, 19446, 31439, 16712, 30241, 4587, 13672, 5172, 19913, 1829, 35186, 5551, 9778, 2407, 9307, 22807, 37495, 22653, 9122, 19528, 3660, 20193, 6055, 2655, 30241, 4587, 4724, 15042, 39182, 11296, 8978, 13672, 5172, 19913, 34051, 20193, 6055, 2655, 30241, 4587, 4724, 15042, 39182, 11296, 8978, 9673, 3615, 1863, 7578, 19446, 20449, 1863, 7578, 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111.12, "end": 111.36, "word": " معنى", "probability": 0.8165690104166666}, {"start": 111.36, "end": 111.76, "word": " التعلق", "probability": 0.96826171875}, {"start": 111.76, "end": 112.08, "word": " اللفظ", "probability": 0.99169921875}, {"start": 112.08, "end": 112.46, "word": " أولا؟", "probability": 0.7623291015625}, {"start": 112.46, "end": 121.88, "word": " ممتاز،", "probability": 0.750390625}, {"start": 121.88, "end": 122.06, "word": " يعني", "probability": 0.942138671875}, {"start": 122.06, "end": 122.5, "word": " التعلق", "probability": 0.94384765625}, {"start": 122.5, "end": 123.1, "word": " اللفظي", "probability": 0.986328125}, {"start": 123.1, "end": 123.32, "word": " هو", "probability": 0.9921875}, {"start": 123.32, "end": 123.48, "word": " أن", "probability": 0.376220703125}, {"start": 123.48, "end": 123.82, "word": " يتعلق", "probability": 0.97802734375}, {"start": 123.82, "end": 124.12, "word": " الكلام", "probability": 0.9567057291666666}, {"start": 124.12, "end": 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الذي تتحدث عنه الآيات الوقف الوقف التام أن يقف القارئ على كلمة القرأن يتم المعنى عندها مستقلة ليس لها التعلق بما بعدها لا من حيث اللفظي ولا من حيث المعنى", "tokens": [6027, 28820, 10943, 9673, 30543, 38688, 47356, 9154, 4386, 9154, 2423, 28820, 10943, 43527, 39182, 3224, 9154, 10874, 3224, 31371, 9673, 3615, 1863, 7578, 6156, 47432, 11778, 11536, 42963, 3615, 23557, 5172, 37495, 22653, 14739, 7251, 2655, 30241, 4587, 2423, 28820, 10943, 20666, 8848, 1829, 39182, 3224, 8978, 9673, 3615, 1863, 7578, 25961, 6055, 30544, 8717, 36178, 21542, 24793, 34051, 8717, 36178, 25062, 9381, 3660, 34051, 8717, 36178, 9673, 2407, 11242, 45367, 43527, 6055, 2655, 24401, 12984, 18871, 3224, 6024, 95, 1829, 9307, 2423, 30543, 5172, 2423, 30543, 5172, 16712, 10943, 14739, 7251, 4587, 5172, 25062, 9640, 19986, 15844, 9122, 19528, 3660, 25062, 2288, 33456, 7251, 39237, 9673, 3615, 1863, 7578, 43242, 11296, 3714, 14851, 4587, 37977, 32239, 3794, 5296, 11296, 16712, 30241, 4587, 4724, 15042, 39182, 11296, 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الوقت الان نكتفي بهذا القدر وان شاء الله في اللقاء القادم بناخد الوقف الحسن ويليه الوقف القبيح حتى ننهي هذا الموضوع وبرك الله فيكم جميعا وجزاكم الله خير و السلام عليكم ورحمة الله وبركاته", "tokens": [2407, 47283, 3215, 8315, 2423, 30543, 5172, 33251, 31845, 1829, 16070, 7649, 8717, 47283, 3215, 2423, 30543, 5172, 21542, 3794, 1863, 35525, 19452, 5296, 7649, 16472, 47395, 7578, 2423, 30543, 2655, 2423, 7649, 8717, 4117, 2655, 41185, 39627, 15730, 25062, 3215, 2288, 4032, 7649, 13412, 16606, 21984, 8978, 13672, 4587, 16606, 25062, 18513, 2304, 44945, 47283, 3215, 2423, 30543, 5172, 21542, 3794, 1863, 4032, 1829, 20292, 3224, 2423, 30543, 5172, 25062, 21292, 5016, 11331, 49975, 8717, 1863, 3224, 1829, 23758, 9673, 2407, 11242, 45367, 4032, 26890, 4117, 21984, 8978, 24793, 10874, 2304, 40228, 995, 4032, 7435, 11622, 995, 24793, 21984, 16490, 13546, 4032, 21136, 37440, 25894, 24793, 4032, 2288, 35571, 3660, 21984, 4032, 26890, 4117, 9307, 3224], "avg_logprob": -0.13393802675655334, "compression_ratio": 2.202970297029703, "no_speech_prob": 9.161233901977539e-05, "words": [{"start": 1939.16, "end": 1939.86, "word": "واخدنا", "probability": 0.9468994140625}, {"start": 1939.86, "end": 1940.26, "word": " الوقف", "probability": 0.9899088541666666}, {"start": 1940.26, "end": 1941.0, "word": " الكافي", "probability": 0.8499348958333334}, {"start": 1941.0, "end": 1941.84, "word": " والان", "probability": 0.409423828125}, {"start": 1941.84, "end": 1942.38, "word": " ناخد", "probability": 0.9811197916666666}, {"start": 1942.38, "end": 1943.04, "word": " الوقف", "probability": 0.97705078125}, {"start": 1943.04, "end": 1944.28, "word": " الحسن", "probability": 0.9708658854166666}, {"start": 1944.28, "end": 1945.06, "word": " ولكن", "probability": 0.8271484375}, {"start": 1945.06, "end": 1945.82, "word": " لان", "probability": 0.6771240234375}, {"start": 1945.82, "end": 1946.2, "word": " انتهى", "probability": 0.80810546875}, {"start": 1946.2, "end": 1946.52, "word": " الوقت", "probability": 0.9894205729166666}, {"start": 1946.52, "end": 1946.8, "word": " الان", "probability": 0.62255859375}, {"start": 1946.8, "end": 1947.5, "word": " نكتفي", "probability": 0.81103515625}, {"start": 1947.5, "end": 1947.92, "word": " بهذا", "probability": 0.919677734375}, {"start": 1947.92, "end": 1948.5, "word": " القدر", "probability": 0.9952799479166666}, {"start": 1948.5, "end": 1948.96, "word": " وان", "probability": 0.8134765625}, {"start": 1948.96, "end": 1949.08, "word": " شاء", "probability": 0.91943359375}, {"start": 1949.08, "end": 1949.18, "word": " الله", "probability": 0.94140625}, {"start": 1949.18, "end": 1949.3, "word": " في", "probability": 0.72705078125}, {"start": 1949.3, "end": 1949.68, "word": " اللقاء", "probability": 0.9933268229166666}, {"start": 1949.68, "end": 1950.36, "word": " القادم", "probability": 0.9949544270833334}, {"start": 1950.36, "end": 1950.8, "word": " بناخد", "probability": 0.8330078125}, {"start": 1950.8, "end": 1951.08, "word": " الوقف", "probability": 0.9908854166666666}, {"start": 1951.08, "end": 1951.56, "word": " الحسن", "probability": 0.9884440104166666}, {"start": 1951.56, "end": 1952.72, "word": " ويليه", "probability": 0.8951416015625}, {"start": 1952.72, "end": 1953.46, "word": " الوقف", "probability": 0.9099934895833334}, {"start": 1953.46, "end": 1954.0, "word": " القبيح", "probability": 0.86083984375}, {"start": 1954.0, "end": 1954.62, "word": " حتى", "probability": 0.867919921875}, {"start": 1954.62, "end": 1955.2, "word": " ننهي", "probability": 0.976806640625}, {"start": 1955.2, "end": 1955.4, "word": " هذا", "probability": 0.96142578125}, {"start": 1955.4, "end": 1955.84, "word": " الموضوع", "probability": 0.998779296875}, {"start": 1955.84, "end": 1956.44, "word": " وبرك", "probability": 0.81982421875}, {"start": 1956.44, "end": 1956.56, "word": " الله", "probability": 0.77685546875}, {"start": 1956.56, "end": 1956.84, "word": " فيكم", "probability": 0.9306640625}, {"start": 1956.84, "end": 1957.34, "word": " جميعا", "probability": 0.95068359375}, {"start": 1957.34, "end": 1957.68, "word": " وجزاكم", "probability": 0.789013671875}, {"start": 1957.68, "end": 1957.8, "word": " الله", "probability": 0.9423828125}, {"start": 1957.8, "end": 1958.14, "word": " خير", "probability": 0.7822265625}, {"start": 1958.14, "end": 1958.5, "word": " و", "probability": 0.62060546875}, {"start": 1958.5, "end": 1958.74, "word": " السلام", "probability": 0.899169921875}, {"start": 1958.74, "end": 1959.08, "word": " عليكم", "probability": 0.92822265625}, {"start": 1959.08, "end": 1959.4, "word": " ورحمة", "probability": 0.9398193359375}, {"start": 1959.4, "end": 1959.66, "word": " الله", "probability": 0.96533203125}, {"start": 1959.66, "end": 1960.4, "word": " وبركاته", "probability": 0.9873046875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1961.110875, "duration_after_vad": 1906.0965937499968}
\ No newline at end of file
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w.srt
new file mode 100644
index 0000000000000000000000000000000000000000..47d1ff541e0801e7b00e2edaebb008653426f40d
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w.srt
@@ -0,0 +1,2071 @@
+1
+00:00:13,420 --> 00:00:16,600
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:16,600 --> 00:00:21,180
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى 
+
+3
+00:00:21,180 --> 00:00:26,690
+آله وصحبه وسلم، أرحبكم في بداية الفصل الدراسي
+
+4
+00:00:26,690 --> 00:00:31,050
+الجديد، سنكون معكم إن شاء الله يا أخوات في متطلب 
+
+5
+00:00:31,050 --> 00:00:34,330
+ومساق من المساقات للجامعة الإسلامية اللي هو
+
+6
+00:00:34,330 --> 00:00:39,970
+التلاوة والتجويد، المطلوب معناها في هذا الفصل هو هذا
+
+7
+00:00:39,970 --> 00:00:44,730
+الكتاب، كتاب المغني في علم التجويد، كتاب للدكتور عبد
+
+8
+00:00:44,730 --> 00:00:50,260
+الرحمن الجمل، كتاب أن يتحدث عن التلاوة والتجويد من 
+
+9
+00:00:50,260 --> 00:00:54,940
+صفحة واحد إلى صفحة 256، سنأخذه إن شاء الله ونسعى
+
+10
+00:00:54,940 --> 00:00:59,260
+بإذن الله عز وجل إلى أن ننتهي من هذا المقرر، نطلب
+
+11
+00:00:59,260 --> 00:01:03,620
+من هذا الكتاب، بالنسبة لتوزيع الدرجات، هيكون في عنا 
+
+12
+00:01:03,620 --> 00:01:07,340
+عشر درجات بإذن الله عز وجل على الحضور والغياب
+
+13
+00:01:07,340 --> 00:01:12,820
+والمناقشة والمشاركة في المحاضرة، وعندنا عشرون درجة
+
+14
+00:01:12,820 --> 00:01:18,570
+على الامتحان النصفي، وكذلك أربعون درجة على الامتحان
+
+15
+00:01:18,570 --> 00:01:24,910
+النهائي، يعني عشرة وعشرون وأربعون، تقريبا سبعون درجة 
+
+16
+00:01:24,910 --> 00:01:29,110
+..سبعون درجة، وهم اللي إلي أنا كمدرس للمادة 
+
+17
+00:01:29,110 --> 00:01:34,430
+النظرية، وفي ثلاثون درجة للعمل، هناك إحدى الأخوات 
+
+18
+00:01:34,430 --> 00:01:39,470
+سوف تأتي عندكم وتدرسكم اللي هي المادة العملية
+
+19
+00:01:39,470 --> 00:01:44,190
+تُدرّسها، أنا عليّ التدريس النظري، والأخت سوف تدرسكم
+
+20
+00:01:44,190 --> 00:01:48,510
+بإذن الله تعالى تدريس عمل التلاوة، يعني تقرأ قرآن 
+
+21
+00:01:48,510 --> 00:01:53,590
+وتطبق الأحكام التي تعلموها على هذه الآيات القرآنية
+
+22
+00:01:53,590 --> 00:01:57,710
+سأكون معكم في هذا الفصل، الدكتور زهدي أبو نعمة،
+
+23
+00:01:57,710 --> 00:02:01,790
+المادة اللي معناها هي التلاوة والتجويد، الموضوع 
+
+24
+00:02:01,790 --> 00:02:06,290
+الأول يا أخوات إن شاء الله هو فضل التلاوة وآدابها، 
+
+25
+00:02:07,390 --> 00:02:10,630
+والموضوع اللي سوف ندرسه نحن اللي هو تعريف القرآن
+
+26
+00:02:10,630 --> 00:02:15,190
+الكريم، وما يتعلق بالقرآن الكريم وآداب التلاوة وما 
+
+27
+00:02:15,190 --> 00:02:20,150
+يتعلق بالقرآن الكريم، من يعرف لنا القرآن الكريم؟ 
+
+28
+00:02:20,150 --> 00:02:25,370
+قدري أخو الكريم، هو كل و لو الله المنّزل على محمد 
+
+29
+00:02:25,370 --> 00:02:28,560
+صلى الله عليه وسلم المنقول إلينا بالتواتر المتعبد 
+
+30
+00:02:28,560 --> 00:02:31,320
+بتلاوته والمبدوء بصورة الفاتحة والمختوم بصورة 
+
+31
+00:02:31,320 --> 00:02:34,240
+الناس، صحيح، القرآن الكريم يا أخوات هو كلام الله 
+
+32
+00:02:34,240 --> 00:02:39,000
+المعجز المنزل على محمد صلى الله عليه وسلم المنقول 
+
+33
+00:02:39,000 --> 00:02:42,840
+إلينا بالتواتر المتعبد بتلاوته والمبدوء بصورة 
+
+34
+00:02:42,840 --> 00:02:47,350
+الفتحِة والمختوم بصورة الناس، كلام الله، قال كلام 
+
+35
+00:02:47,350 --> 00:02:51,210
+الله، حتى نميز كلام الله عن كلام غيره، هناك كلام 
+
+36
+00:02:51,210 --> 00:02:55,510
+للملائكة، كلام للإنس، كلام للجن، فكلام الله وكلام 
+
+37
+00:02:55,510 --> 00:02:59,490
+الله عز وجل إيش؟ معجز، ربنا سبحانه وتعالى جعل
+
+38
+00:02:59,490 --> 00:03:03,710
+رسالة محمد صلى الله عليه وسلم رسالة خالدة، والقرآن
+
+39
+00:03:03,710 --> 00:03:07,010
+أو معجزة الرسول عليه الصلاة والسلام معجزة خالدة و
+
+40
+00:03:07,010 --> 00:03:12,030
+هي القرآن الكريم، فهو معجز ببيانه ولفظه ومعانيه
+
+41
+00:03:12,030 --> 00:03:15,770
+فهو كلام الله المعجز، وربنا سبحانه وتعالى تحدى 
+
+42
+00:03:15,770 --> 00:03:20,350
+الإنس والجن أن يأتوا بمثل هذا القرآن، فعجزوا، فقال
+
+43
+00:03:20,350 --> 00:03:24,810
+تعالى: قل: إن اجتمعت الإنس والجن على أن يأتوا بمثل
+
+44
+00:03:24,810 --> 00:03:29,430
+هذا القرآن لا يأتون بمثله، ولو كان بعضهم لبعض ظهيرًا
+
+45
+00:03:29,430 --> 00:03:34,890
+ثم تحدى العرب وهم أهل البلاغة والفصاحة وال
+
+46
+00:03:34,890 --> 00:03:39,070
+بيان،  يُحَدّدهم أن يأتوا بصورة واحدة من مثله، فعجزوا
+
+47
+00:03:39,070 --> 00:03:43,950
+أشرب، الله سبحانه وتعالى يقول: وإن كنتم في ريب مما
+
+48
+00:03:43,950 --> 00:03:49,250
+نزلنا على عبدنا فاتوا بصورة من مثله وادعوا شهداءكم
+
+49
+00:03:49,250 --> 00:03:54,430
+من دون الله إن كنتم صادقين، فعجزوا، فالقرآن معجز
+
+50
+00:03:54,430 --> 00:04:00,510
+ببيانه وبلاغته وفصاحته ومعانيه وغير ذلك، المنزل على 
+
+51
+00:04:00,510 --> 00:04:04,530
+محمد صلى الله عليه وسلم، لماذا قلنا المنزل على
+
+52
+00:04:04,530 --> 00:04:11,690
+محمد؟ لأن هناك كتب أنزلت على غير محمد، هناك التوراة 
+
+53
+00:04:11,690 --> 00:04:16,650
+أنزلت على مين؟ على سيدنا موسى، الإنجيل على سيدنا
+
+54
+00:04:16,650 --> 00:04:22,430
+عيسى، الزبور على سيدنا داود، الصحف على سيدنا محمد
+
+55
+00:04:22,430 --> 00:04:26,390
+وهناك كتب أخرى أنزلت على أنبياء لم يرد ذكرهم في 
+
+56
+00:04:26,390 --> 00:04:31,120
+القرآن، لكننا نؤمن بأن هناك أنبياء آخرون وأرسل إليهم
+
+57
+00:04:31,120 --> 00:04:35,620
+الكتب من عند الله عز وجل، فهو كلام الله المعجز
+
+58
+00:04:35,620 --> 00:04:40,200
+المنزل على محمد صلى الله عليه وسلم المنقول إلينا 
+
+59
+00:04:40,200 --> 00:04:44,220
+بالتواتر، ما معنى المنقول إلينا بالتواتر؟ 
+
+60
+00:04:49,130 --> 00:04:55,410
+صحيح، التواتر هو ما نقله جمع عن جمع في كل طبقة من
+
+61
+00:04:55,410 --> 00:04:59,830
+طبقات السند، يستحيل عادي تواطؤهم على الكلمة، يعني
+
+62
+00:04:59,830 --> 00:05:04,130
+الرسول عليه الصلاة والسلام أنزل عليه القرآن، فعلمه
+
+63
+00:05:04,130 --> 00:05:08,990
+لمين؟ للصحابة، عدد الصحابة بمجموعه 120 ألف صحابي
+
+64
+00:05:08,990 --> 00:05:14,040
+تقريبًا كما يقول العلماء، هؤلاء الـ 120 ألف صحابي 
+
+65
+00:05:14,040 --> 00:05:18,060
+علموه لمين؟ للتابعين، أكيد هم هيكونوا أكثر من الـ 120 
+
+66
+00:05:18,060 --> 00:05:23,040
+ألف، والتابعون علموه لأتباع التابعين وهكذا حتى وصل
+
+67
+00:05:23,040 --> 00:05:27,600
+القرآن إلينا بفضل الله عز وجل، ولذلك حتى الآن هناك
+
+68
+00:05:27,600 --> 00:05:31,180
+من الناس من يحملوا السند إلى الرسول عليه الصلاة 
+
+69
+00:05:31,180 --> 00:05:34,820
+والسلام، يقول مثلا: أخذوا القرآن عن فلان، عن فلان، عن 
+
+70
+00:05:34,820 --> 00:05:38,340
+فلان إلى الرسول صلى الله عليه وسلم، وفي الجامعة 
+
+71
+00:05:38,340 --> 00:05:41,760
+الإسلامية في هناك كثير من الطلاب والطالبات وفي غزة
+
+72
+00:05:41,760 --> 00:05:45,840
+من يحمل السند إلى الرسول صلى الله عليه وسلم تبركًا
+
+73
+00:05:45,840 --> 00:05:51,460
+أن نفسه اتصل بنفس الرسول عليه الصلاة والسلام، إذا
+
+74
+00:05:51,460 --> 00:05:56,300
+وصل القرآن إلينا متواتر جيل عن جيل بلغون هذا 
+
+75
+00:05:56,300 --> 00:06:02,220
+القرآن مشافهة ووصلنا كذلك مكتوبًا على الصفحة، إذا
+
+76
+00:06:02,220 --> 00:06:05,920
+المنقول إلينا بالتواتر المتعبد بتلاوته، ما معنى
+
+77
+00:06:05,920 --> 00:06:07,920
+أخوات المتعبد بتلاوته؟
+
+78
+00:06:10,150 --> 00:06:14,150
+يعني نحن نتعبد الله بتلاوتنا للقرآن الكريم، نصلي 
+
+79
+00:06:14,150 --> 00:06:18,610
+فنقرأ القرآن، وإذا أردنا أن نحصل الأجر نقرأ القرآن 
+
+80
+00:06:18,610 --> 00:06:23,830
+تعبدًا، والرسول عليه الصلاة والسلام يقول لنا: من قرأ 
+
+81
+00:06:23,830 --> 00:06:29,170
+حرفًا من كتاب الله تعالى له به حسنة والحسنة بعشر 
+
+82
+00:06:29,170 --> 00:06:34,450
+أمثالها، لا أقول ألف، لم من حرف، ولكن ألف حرف، ولم حرف 
+
+83
+00:06:34,450 --> 00:06:39,010
+وم من حرف، إذا كل حرف نقرأه من كتاب الله تعالى لنا
+
+84
+00:06:39,010 --> 00:06:45,700
+به كام؟ عشر حسنات، لو كلمة فيها خمس حروف، خمسة ضرب 
+
+85
+00:06:45,700 --> 00:06:51,880
+عشرة، خمسون، لو سطر في عشر كلمات، خمسة عشر ضرب 
+
+86
+00:06:51,880 --> 00:06:59,490
+خمسين حسنة بخمسمائة حسنة، الصفحة فيها خمسة عشر سطر
+
+87
+00:06:59,490 --> 00:07:04,590
+يعني العدد عشرة ضرب خمسين ضرب خمسة عشر بيطلع عدد
+
+88
+00:07:04,590 --> 00:07:09,770
+كبير، في الجزء مثلًا خمسة وعشرون صفحة بيصير الواحد 
+
+89
+00:07:09,770 --> 00:07:14,150
+مليونير حسنات في خلال نصف ساعة وهو يقرأ القرآن، إذا 
+
+90
+00:07:14,150 --> 00:07:18,510
+نحن نتعبد الله سبحانه وتعالى بتلاوتنا للقرآن 
+
+91
+00:07:18,510 --> 00:07:23,330
+الكريم، طبعًا ليه صحة، مثلا أن يصلي الإنسان ويقرأ 
+
+92
+00:07:23,330 --> 00:07:28,530
+غير القرآن في الصلاة؟ لو قرأ حديثًا نبويًا هل يصح؟ ولو
+
+93
+00:07:28,530 --> 00:07:32,730
+حتى يقرأ صحيح البخاري والكتاب الفقه أو أي شيء لا 
+
+94
+00:07:32,730 --> 00:07:36,690
+يصح لنا إلا أن نقرأ القرآن في الصلاة، فنحن نتعبد
+
+95
+00:07:36,690 --> 00:07:41,310
+الله في صلاتنا ولنا أجر عظيم في تلاوتنا للقرآن
+
+96
+00:07:41,310 --> 00:07:44,490
+الكريم، وهذا القرآن يا أخوات مبدوء بصورة الفاتحة 
+
+97
+00:07:44,490 --> 00:07:49,230
+ومختتم بصورة الناس، وهو الكتاب الذي هو مكتوب بين
+
+98
+00:07:49,230 --> 00:07:53,790
+أيدينا، وللقرآن الكريم فضل في التلاوة، الذي يتلو
+
+99
+00:07:53,790 --> 00:07:58,600
+القرآن له أجر عظيم، ورد ذلك يا أخوات في الكتاب وفي 
+
+100
+00:07:58,600 --> 00:08:03,020
+السنة، نشوف مثلا في الكتاب نجد كلنا آية قرآنية
+
+101
+00:08:03,020 --> 00:08:07,000
+تتحدث عن فضل تلاوة القرآن الكريم، طبعا الكلام كله 
+
+102
+00:08:07,000 --> 00:08:10,960
+موجود بين أيديكم، بإمكانكم أن يعني بس نريد منكم أن
+
+103
+00:08:10,960 --> 00:08:14,480
+تشاركوا في هذه المحاضرة، تفضل أخت، بسم الله الرحمن
+
+104
+00:08:14,480 --> 00:08:20,280
+الرحيم، الذين آتيناهم الكتاب يتلونه حق تلاوته، الله 
+
+105
+00:08:20,280 --> 00:08:25,300
+تعالى، ورتّل القرآن ترتيلًا، أحسنتِ، الذين آتيناهم 
+
+106
+00:08:25,300 --> 00:08:30,340
+الكتاب يتلونه حق تلاوته، نريد أن نتلو القرآن حق 
+
+107
+00:08:30,340 --> 00:08:34,700
+تلاوته، والله عز وجل يقول لنا كذلك ورتّل القرآن
+
+108
+00:08:34,700 --> 00:08:40,200
+ترتيلاً، وكذلك هناك أحاديث نبوية تبين فضل تلاوة
+
+109
+00:08:40,200 --> 00:08:44,720
+القرآن كذلك، وأن الذي يتلو القرآن له إيش أخوات؟ له
+
+110
+00:08:44,720 --> 00:08:49,360
+أجر عظيم، من يذكر لنا أحاديث نبوية تدل على فضل
+
+111
+00:08:49,360 --> 00:08:50,340
+تلاوة القرآن كذلك؟
+
+112
+00:08:54,630 --> 00:08:59,650
+صحيح، خيركم من تعلم القرآن وعلمَه، الحديث رواه مين؟
+
+113
+00:08:59,650 --> 00:09:05,240
+البخاري، ما معنى حديث رواه البخاري؟ البخاري يا أخوات
+
+114
+00:09:05,240 --> 00:09:09,440
+هو أصح كتاب بعد كتاب الله تعالى، لأن الإمام البخاري 
+
+115
+00:09:09,440 --> 00:09:13,240
+اتخذ يعني أسلوبًا معينًا في انتقاء الأحاديث الصحيحة
+
+116
+00:09:13,240 --> 00:09:17,160
+وكانت الأحاديث الصحيحة كلها بدقة بحيث تكون أحاديث
+
+117
+00:09:17,160 --> 00:09:20,280
+صحيحة مروية عند الرسول صلى الله عليه وسلم، فعندما
+
+118
+00:09:20,280 --> 00:09:24,280
+نقول صحيح البخاري، نحن على يقين بأن النبي عليه
+
+119
+00:09:24,280 --> 00:09:29,240
+الصلاة والسلام قد قال هذا الكلام، وهو خيركم من تعلم
+
+120
+00:09:29,240 --> 00:09:33,970
+القرآن وعلمها، حديث آخر يا أخوات، فضيلة عن عائشة رضي 
+
+121
+00:09:33,970 --> 00:09:37,030
+الله عنها، النبي صلى الله عليه وسلم، والخلق الذي
+
+122
+00:09:37,030 --> 00:09:42,210
+يقرأ القرآن وهو مع سفرة الكرام البررة، والذي يشتد
+
+123
+00:09:42,210 --> 00:09:46,190
+عليه على أي فرق، أجريتمّمتاز، بأيضًا حديث رواه مسلم،
+
+124
+00:09:46,190 --> 00:09:49,530
+يعني حديث صحيح رواه مسلم، لأنه أصح كتاب بعد كتاب 
+
+125
+00:09:49,530 --> 00:09:53,490
+الله، البخاري ثم يليه الإمام مسلم، وبعد ذلك كتب
+
+126
+00:09:53,490 --> 00:09:57,550
+السنن، الترمذي، النسائي، وابو داود، وابن ماجه وغير ذلك من
+
+127
+00:09:57,550 --> 00:10:00,770
+الكتب، هنا النبي عليه الصلاة والسلام يبين لنا الأجر 
+
+128
+00:10:00,770 --> 00:10:05,210
+الذي يقرأ القرآن وهو ماهر به مع السفرة الكرام 
+
+129
+00:10:05,210 --> 00:10:10,120
+البررة، من هم السفرة الكرام البررة؟ الملائكة، يعني 
+
+130
+00:10:10,120 --> 00:10:14,520
+بيكون ربنا سبحانه وتعالى رفع درجته ومقداره، فهو مع
+
+131
+00:10:14,520 --> 00:10:18,800
+الملائكة لأنه يتلو القرآن وتقرَأ به إلى الله عز وجل 
+
+132
+00:10:18,800 --> 00:10:23,480
+والذي يشتد عليه القرآن فله أجران، يعني أو حديث آخر
+
+133
+00:10:23,480 --> 00:10:27,960
+والذي يقرأ القرآن ويتعثر فيه وهو عليه شاق له أجران
+
+134
+00:10:27,960 --> 00:10:32,360
+في رواية أخرى، إذا حتى الإنسان الذي لا يستطيع أن
+
+135
+00:10:32,360 --> 00:10:36,420
+يقرأ القرآن أو يجد مشقة في تلاوة القرآن ويتعثر
+
+136
+00:10:36,420 --> 00:10:40,640
+فيه، فلا نقول له أنت لا تقرأ لأنك تتعثر في القرآن،
+
+137
+00:10:40,640 --> 00:10:46,680
+نقول لك هنيئًا لك فإن النبي صلى الله عليه وسلم بشرَك 
+
+138
+00:10:46,680 --> 00:10:52,650
+بأن لك أجرين، لكن عليك أن تقرأ القرآن وتجتهد في تعلم 
+
+139
+00:10:52,650 --> 00:10:57,750
+القرآن حتى تكون مثل مين؟ مثل السفرة الكرام البررة
+
+140
+00:10:57,750 --> 00:11:01,370
+وهم الذين يقرؤون القرآن بمهارة، حديث آخر يا أخوات
+
+141
+00:11:01,370 --> 00:11:07,350
+فضليه صحيح
+
+142
+00:11:07,350 --> 00:11:12,610
+مظبوط كذا حديث آخر فضليه ما معنى يا أخوات ما لم
+
+143
+00:11:12,610 --> 00:11:19,650
+يتغنى بالقرآن فليس مننا يعني يقرأ القرآن بصوت ندي
+
+144
+00:11:19,650 --> 00:11:23,450
+حسن مطبقًا لأحكام التجويض والنبي عليه الصلاة 
+
+145
+00:11:23,450 --> 00:11:27,870
+والسلام كان يقرأ القرآن مجودًا بل إن جبريل عليه
+
+146
+00:11:27,870 --> 00:11:31,130
+الصلاة والسلام لما كان ينزل القرآن على محمد كان
+
+147
+00:11:31,130 --> 00:11:34,590
+ينزله مجودًا والرسول صلى الله عليه وسلم يعلمه
+
+148
+00:11:34,590 --> 00:11:38,690
+للصحابة مجودًا والصحابة كانوا يأخذونه مشافهة من
+
+149
+00:11:38,690 --> 00:11:42,070
+الرسول صلى الله عليه وسلم مجودًا ويعلمونه للتابعين
+
+150
+00:11:42,070 --> 00:11:47,680
+فالقرآن يُأخذ بالمشافهة مجودًا ذلك لابد أن يحسن 
+
+151
+00:11:47,680 --> 00:11:52,060
+الإنسان تلاوته بالقرآن وقد كان النبي عليه الصلاة
+
+152
+00:11:52,060 --> 00:11:56,920
+والسلام يتعرف على بيوت أصحابه من أصواتهم في
+
+153
+00:11:56,920 --> 00:12:01,160
+تلاوتهم للقرآن في الليل فقد ورد أن النبي صلى الله
+
+154
+00:12:01,160 --> 00:12:06,700
+عليه وسلم كان يتفقد أحوال الرعية في الليل فسمع صوت
+
+155
+00:12:06,700 --> 00:12:11,480
+أبي موسى الأشعري وهو في بيته يتلو القرآن فقال له في
+
+156
+00:12:11,480 --> 00:12:14,180
+اليوم الثاني عرف أن هذا البيت هو بيت أبو موسى
+
+157
+00:12:14,180 --> 00:12:17,520
+الأشعري فقال له في اليوم الثاني لو رأيتني وأنا
+
+158
+00:12:17,520 --> 00:12:22,600
+أستمع لقرائتك البارحة لقد أوتيت مزمارا من مزامير
+
+159
+00:12:22,600 --> 00:12:27,860
+أهل دول فقال له أبو موسى لو علمت أنك تستمع إليا
+
+160
+00:12:29,010 --> 00:12:36,210
+لحبرته لك تحبيرة يعني ازددته تحسينا لهذه التلاوة و
+
+161
+00:12:36,210 --> 00:12:40,530
+قرأته بصوت حسن أنا كنت أقرأ القرآن لنفسي فلو علمت 
+
+162
+00:12:40,530 --> 00:12:45,470
+أنك تستمع لي لزدته من جمال القرآن ولا استمتعته
+
+163
+00:12:45,470 --> 00:12:48,490
+طبعًا يا أخوات الواحد لما يقرأ القرآن بصوت جمال هو
+
+164
+00:12:48,490 --> 00:12:53,190
+نفسه يشعر باللذة ويستمتع ويتغنى بالقرآن لذلك ليس
+
+165
+00:12:53,190 --> 00:12:57,990
+مننا من يتغنى بالقرآن كذلك الحديث الآخر يبين فضل
+
+166
+00:12:57,990 --> 00:13:01,970
+تلاوة القرآن إيش يا أخوان؟ من يقرأ؟ فضلي
+
+167
+00:13:17,990 --> 00:13:22,700
+أحسن طبعًا الحديث اللي هو ترمي دي حسن وأنصحي من قرأ
+
+168
+00:13:22,700 --> 00:13:26,180
+حرفًا من كتاب الله تعالى له به حسنة، والحسنة بعشر
+
+169
+00:13:26,180 --> 00:13:30,380
+أمثالها، لا أقول ألف، لام، ميم حرف، ولكن ألف حرف
+
+170
+00:13:30,380 --> 00:13:34,220
+ولام حرف وميم حرف كذلك يقال كما قال النبي عليه
+
+171
+00:13:34,220 --> 00:13:38,500
+الصلاة والسلام يقال لقارئ القرآن اقرأ ورتل
+
+172
+00:13:38,500 --> 00:13:43,560
+كما كنت ترتل في الدنيا فإن منزلتك عند آخر آية
+
+173
+00:13:43,560 --> 00:13:46,980
+تقرأها وحديث آخر يعني يقول النبي عليه الصلاة
+
+174
+00:13:46,980 --> 00:13:52,240
+والسلام من قرأ القرآن وعمل بما فيه ألبس والديه
+
+175
+00:13:52,240 --> 00:13:57,140
+تاجًا يوم القيامة ضوءه أحسن من ضوء الشمس فما ظنكم 
+
+176
+00:13:57,140 --> 00:14:02,820
+بالذي عمل بهذا؟ رواه الحاكم ما معنى رواه الحاكم؟
+
+177
+00:14:02,820 --> 00:14:07,040
+يعني أي حاكم ولا واحد؟ الحاكم في المستدرك في
+
+178
+00:14:07,040 --> 00:14:10,540
+المستدرك على الصحيحين على شرط البخاري ومسلم
+
+179
+00:14:10,540 --> 00:14:14,500
+الأحاديث التي وردت في صحيح .. يعني في المستدرك
+
+180
+00:14:14,500 --> 00:14:19,700
+الحاكم لها يعني قريبة من أو هي نفسها شروط البخاري
+
+181
+00:14:19,700 --> 00:14:25,780
+ومسلم وتأخذ بها وهي صحيحة هذه يا أخوات يعني بعض
+
+182
+00:14:25,780 --> 00:14:30,780
+الآثار أو آيات قرآنية وحديث نبوية تبين فضل تلاوة
+
+183
+00:14:30,780 --> 00:14:34,580
+القرآن الكريم ولكن القرآن الكريم كلام الله عز وجل
+
+184
+00:14:34,580 --> 00:14:39,660
+وينبغي علينا أن نتلوه ونحن نعظم كلام الله عز وجل
+
+185
+00:14:39,660 --> 00:14:45,760
+ولذلك لتلاوة القرآن أداب ما هي الأداب التي ينبغي
+
+186
+00:14:45,760 --> 00:14:50,580
+علينا أن نراعيها أثناء تلاوتنا للقرآن الكريم؟ في
+
+187
+00:14:50,580 --> 00:14:55,800
+أداب معينة الأدب الأول فضل إيه؟ صحيح
+
+188
+00:14:56,350 --> 00:14:59,910
+كلام الله عز وجل هو شعيرة من شعائر الله وهو صفة
+
+189
+00:14:59,910 --> 00:15:03,230
+قديمة من صفات الله سبحانه وتعالى لابد أن نعظمها
+
+190
+00:15:03,230 --> 00:15:08,090
+كما نعظم الله عز وجل ونعظم الكعبة ونعظم المقدسات
+
+191
+00:15:08,090 --> 00:15:12,330
+التي عندنا وهي يعني عظيم جدا لذلك الذي يتلو القرآن
+
+192
+00:15:12,330 --> 00:15:16,950
+الكريم لابد أن يعظمه يعظمه في التلاوة ويعظمه في
+
+193
+00:15:16,950 --> 00:15:20,510
+المعنى وكذلك يعظمه لو كانت عندنا مجموعة من 
+
+194
+00:15:20,510 --> 00:15:25,010
+المصاحف أو كتب معينة محطوطة على الطاولة يعني ده
+
+195
+00:15:25,010 --> 00:15:29,370
+يجعل المصحف أول مصحف أول .. أول كتب من باب تعظيم
+
+196
+00:15:29,370 --> 00:15:33,660
+شعائر الله ربنا سبحانه وتعالى يقول وما يعظم شعائر
+
+197
+00:15:33,660 --> 00:15:38,520
+الله فإنها من تقوى القلوب إذا نعظم كلام الله لأنه
+
+198
+00:15:38,520 --> 00:15:42,000
+من شعائر الله عز وجل لأنه صفر من صفات الله سبحانه
+
+199
+00:15:42,000 --> 00:15:47,080
+وتعالى فنتلو القرآن ونحن نعظم القرآن الكريم ولنا
+
+200
+00:15:47,080 --> 00:15:51,280
+أجر عظيم على تعليمنا أو تعظيمنا للقرآن الكريم لو
+
+201
+00:15:51,280 --> 00:15:58,450
+واحد يا أخوات وجدت مثلًا كلمة فيها لفظ الجلالة يعني
+
+202
+00:15:58,450 --> 00:16:04,350
+اسم الله جزء من المصحف لفظ الجلالة مُلقى على 
+
+203
+00:16:04,350 --> 00:16:09,050
+الأرض حتى نعظم لفظ الجلالة ونعظم كلام الله عز وجل
+
+204
+00:16:09,050 --> 00:16:14,500
+ماذا نفعل؟ هل نجعلها مرمية على الأرض ولا نأخذها ون
+
+205
+00:16:14,500 --> 00:16:19,740
+رفعها ونضعها في مكان عظيم أو مكان مناسب أو إذا
+
+206
+00:16:19,740 --> 00:16:24,440
+كانت ورقة ممزقة نحرّجها لا نلقيها لا في القمامة ولا
+
+207
+00:16:24,440 --> 00:16:29,660
+نرميها على الأرض لذلك ذلك من باب تعظيم لكلام الله
+
+208
+00:16:29,660 --> 00:16:35,590
+عز وجل ولشعائر الله سبحانه وتعالى طيب أدب آخر من
+
+209
+00:16:35,590 --> 00:16:39,090
+أداب تلاوة القرآن، تفضلي تدور القلب والتدبر فيها
+
+210
+00:16:39,090 --> 00:16:42,850
+لتلاوة وفهم معانيه صحيح يعني لابد لمن أراد أن 
+
+211
+00:16:42,850 --> 00:16:48,000
+يقرأ القرآن أن يتدبر معاني القرآن الكريم وأن يعلم
+
+212
+00:16:48,000 --> 00:16:52,740
+بأن هو هو نفسه المخاطب بهذه الآية القرآنية إذا
+
+213
+00:16:52,740 --> 00:16:55,680
+الله سبحانه وتعالى قال له يا أيها الذين آمنوا 
+
+214
+00:16:55,680 --> 00:16:59,620
+فليعلم أنه هو من الذين آمنوا وأن هذا الخطاب له
+
+215
+00:16:59,620 --> 00:17:04,530
+وإذا ذُكرت الجنة أو النار يتذكر بأن هذا الجنة
+
+216
+00:17:04,530 --> 00:17:08,010
+والنار ربنا سبحانه وتعالى جاء النار جعلها للكفار 
+
+217
+00:17:08,010 --> 00:17:11,250
+والجنة جعلها للمؤمنين فيسأل الله الجنة ويستعيذ
+
+218
+00:17:11,250 --> 00:17:17,070
+بالله من النار لذلك يبقى متعلق بالآية يتدبر ويتفكر
+
+219
+00:17:17,070 --> 00:17:21,970
+بها لا يكن قلبه غافلًا لا يكن يقرأ القرآن وقلبه في
+
+220
+00:17:21,970 --> 00:17:26,570
+تفكير آخر الله سبحانه وتعالى يقول كتابًا أنزلناه 
+
+221
+00:17:26,570 --> 00:17:31,400
+إليك مبارك ليتدبر آياته وليتذكر أولي الألباب إذا
+
+222
+00:17:31,400 --> 00:17:36,400
+تدبر وتفكر وربنا عز وجل يقول أفلا يتدبرون القرآن
+
+223
+00:17:36,400 --> 00:17:42,300
+أم على قلوب أقفالها إذا الأدب الثاني حضور القلب
+
+224
+00:17:42,300 --> 00:17:46,960
+وتدبر فيه عند تلاوته وفهم معانيه من يذكر أدبًا
+
+225
+00:17:46,960 --> 00:17:53,880
+ثالثًا؟ تفضلي أختك صحيح نقرأ القرآن مرتلًا والله 
+
+226
+00:17:53,880 --> 00:17:57,960
+سبحانه وتعالى يقول ورتل القرآن ترتيلة مطلوب إننا
+
+227
+00:17:57,960 --> 00:18:03,260
+نرتل القرآن مجودًا ومن هنا نحن نتعلم أحكام التجويض
+
+228
+00:18:03,260 --> 00:18:07,340
+نتعلم أحكام التجويض حتى إيش أخوات نرتل القرآن
+
+229
+00:18:07,340 --> 00:18:11,060
+ترتيلة لا نتعلمهم من باب الترف بل نتعلمهم من باب
+
+230
+00:18:11,060 --> 00:18:15,360
+التطبيق يعني نتعلم أحكام التجويض وإذا رجعنا إلى 
+
+231
+00:18:15,360 --> 00:18:20,350
+بيوتنا نطبق ما تعلمناه على كتاب الله عز وجل ومن
+
+232
+00:18:20,350 --> 00:18:24,190
+هنا هذا المساق .. مساق التلاوة والتجويض فيه جانبين
+
+233
+00:18:24,190 --> 00:18:29,110
+جانب عملي وجانب نظري نحن في هذه المحاضرة نتحدث عن
+
+234
+00:18:29,110 --> 00:18:33,970
+جانب النظري نتعلم أحكام التجويض وهناك محاضرة أخرى
+
+235
+00:18:34,220 --> 00:18:39,060
+زيادة أو رديفة لهذه المحاضرة وهي الجانب التطبيقي
+
+236
+00:18:39,060 --> 00:18:42,820
+يعني نقرأ آيات من القرآن الكريم ونطبقها بإذن الله 
+
+237
+00:18:42,820 --> 00:18:48,560
+عز وجل طيب أدب آخر يا أخوات فضليه أن يزين القارئ
+
+238
+00:18:48,560 --> 00:18:52,220
+قراءته ويحسن صوته بالقرآن صحيح يزينوا قراءته
+
+239
+00:18:52,220 --> 00:18:56,560
+ويحسنوا صوته بالقرآن الرسول عليه الصلاة والسلام 
+
+240
+00:18:56,560 --> 00:19:01,420
+يقول لنا زينوا أصواتكم بالقرآن فإن الصوت الحسن
+
+241
+00:19:01,420 --> 00:19:06,120
+يزيد القرآن حسنه علينا أن نزين أصواتنا طبعًا يا
+
+242
+00:19:06,120 --> 00:19:11,180
+أخوات معروف أن الواحد يعني عندما يستمتع أو يستمع
+
+243
+00:19:11,180 --> 00:19:16,350
+إلى قارئ ذي صوت حسن إيش بيصير فيه؟ يشعر بال ..
+
+244
+00:19:16,350 --> 00:19:20,830
+باللذة، بالسكينة، بالهدوء، بالتدبر، بالتفكر، بهذه 
+
+245
+00:19:20,830 --> 00:19:25,070
+الأصوات النقية وإذا سمع صوتًا .. يعني .. يعني ..
+
+246
+00:19:25,070 --> 00:19:29,290
+يعني لو قرأ .. لو سمع واحد يقرأ القرآن كما يقرأ من
+
+247
+00:19:29,290 --> 00:19:34,030
+كتاب أو من جريدة لا يجد هذه المتعة أو هذه اللذة في
+
+248
+00:19:34,030 --> 00:19:39,050
+تلاوته للقرآن لذلك حسنوا أصواتكم بالقرآن فإن الصوت
+
+249
+00:19:39,050 --> 00:19:43,490
+الحسن يزيد القرآن حسنًا طبعًا نجد يا أخوات أن بعض 
+
+250
+00:19:43,490 --> 00:19:47,630
+الناس في صلاة التراويح في رمضان ينتقل من مسجد إلى
+
+251
+00:19:47,630 --> 00:19:53,050
+مسجد ينظر إلى صوت الإمام وقراءة الإمام إن كانت
+
+252
+00:19:53,050 --> 00:19:56,970
+قراءة حسنة وصوته ندي ينتقل من المسجد إلى حارة 
+
+253
+00:19:56,970 --> 00:20:01,290
+ثانية أو إلى مكان آخر لكي يستمع ويستمتع بصلاة
+
+254
+00:20:01,290 --> 00:20:05,130
+التراويح لأنه يريد أن يصلي عشرين ركعة أو يصلي
+
+255
+00:20:05,130 --> 00:20:09,190
+مثلاً تمام ركعات بصوت حسن فيجوز ينتقل من مكان إلى
+
+256
+00:20:09,190 --> 00:20:13,090
+مكان بس بشرط عدم إغلاق المسجد الذي هو فيه يعني إذا 
+
+257
+00:20:13,090 --> 00:20:17,610
+كان والله المسجد الذي هو فيه آه ما بقولك، يعني إذا
+
+258
+00:20:17,610 --> 00:20:21,330
+كان يؤدي ذلك إلى إغلاق المسجد، لا، يبقى في مسجده،
+
+259
+00:20:21,330 --> 00:20:25,790
+لكن إذا كان يريد أن يتدبر ويتفكر ويخشع ويذهب إلى
+
+260
+00:20:25,790 --> 00:20:29,290
+الإمام أو المسجد اللي فيه إمام منحسن، يعني يجوز له
+
+261
+00:20:29,290 --> 00:20:34,170
+ذلك ولا شيء عليه، أدب آخر يا أخوات، تفضلي أخت يقول
+
+262
+00:20:34,170 --> 00:20:36,330
+أن يقرأ على طهارة كاملة في البدن والثوب
+
+263
+00:20:36,330 --> 00:20:40,110
+والمكان، لقال الله تعالى إنه لقرآن كريم في كتابه
+
+264
+00:20:41,760 --> 00:20:45,780
+لا يمسه إلا المطهرون صحيح يا أخوات لابد لمن أراد أن
+
+265
+00:20:45,780 --> 00:20:50,260
+يقرأ القرآن أن يكون على طهارة كاملة طهارة البدن
+
+266
+00:20:50,260 --> 00:20:53,660
+والثوب والمكان ما معنى طهارة البدن يا أخوات؟
+
+267
+00:20:56,090 --> 00:21:01,170
+يعني طهارة البدن من الجنابة من الحيض من النفاس
+
+268
+00:21:01,170 --> 00:21:06,810
+يكون ليس عليه نجاسات معينة مثلًا يكونوا على وضوء
+
+269
+00:21:06,810 --> 00:21:11,310
+هذه الطهارة لأن القرآن لا يمسه إلا المطهرون طهارة 
+
+270
+00:21:11,310 --> 00:21:15,750
+البدن وطَهارة الثوب وطَهارة المكان طهارة الثوب إيه
+
+271
+00:21:15,750 --> 00:21:21,230
+شروط طهارة الثوب؟ ألا يكون على ملابسه نجاسة مطهرة
+
+272
+00:21:21,230 --> 00:21:24,830
+المكان أن يكون المكان الذي يقرأ القرآن فيه مكان
+
+273
+00:21:24,830 --> 00:21:29,710
+يعني نظيف وطاهر لا يقرأ القرآن في مكان نجاسات في 
+
+274
+00:21:29,710 --> 00:21:33,670
+مكان يعني في .. في مكان يعني لا غير مناسب يقرأ
+
+275
+00:21:33,670 --> 00:21:38,030
+القرآن ويتدبر القرآن حتى يحصل الأجر العظيم الذي
+
+276
+00:21:38,030 --> 00:21:42,630
+جعله الله عز وجل لمن يقرأ القرآن من يأتي بأدب آخر
+
+277
+00:21:42,630 --> 00:21:47,690
+فضل أخت أتت بأدب القرآن وخشوع ولا يعرف القرآن؟
+
+278
+00:21:49,620 --> 00:21:53,440
+أحسنتِ تبقى نتأدب عند تلاوة القرآن الكريم نعرف 
+
+279
+00:21:53,440 --> 00:21:58,260
+أننا نقرأ كلام الله نقف بين يدي الله عز وجل لا
+
+280
+00:21:58,260 --> 00:22:03,140
+نضحك ولا نعبث ولا ننظر إلى ما يلهي لا ننظر إلى
+
+281
+00:22:03,140 --> 00:22:08,700
+التلفزيون مثلا أو إلى لعبة كرة قدم أو إلى الشارع
+
+282
+00:22:08,700 --> 00:22:13,720
+فيه هناك مشاكل و أنا أتلُّ القرآن لأ لا أود أن يعني
+
+283
+00:22:13,720 --> 00:22:17,800
+أتدبر الآيات و أتأدب عند تلاوتي للقرآن الكريم فلا
+
+284
+00:22:17,800 --> 00:22:24,000
+أفعل شيء يعني يلهي عن القرآن الكريم لأضحك ولا ألعب
+
+285
+00:22:24,000 --> 00:22:28,840
+أو أعبث ولا أنظر إلى ما يلهي ومن الأداب والأخلاق
+
+286
+00:22:28,840 --> 00:22:32,440
+الحسنة أن أكون مستقبلا للقبلة  الشرّيفة طبعا هذه
+
+287
+00:22:32,440 --> 00:22:36,680
+أخوات أداب يعني لو واحد مثلا كان بسوق سيارة وقعد
+
+288
+00:22:36,680 --> 00:22:40,160
+بيقرأ القرآن من باب أنه يستغل وقته في قراءة القرآن 
+
+289
+00:22:40,160 --> 00:22:44,240
+جائز لو واحد مثلا كان رايح على الجامع أو المسجد
+
+290
+00:22:44,240 --> 00:22:48,120
+ويريد في الطريق أن يتذكر الآيات القرآنية حسن يقراء
+
+291
+00:22:48,120 --> 00:22:54,000
+القرآن لو كان نايم أو يعني مضطجع و يريد أن يذكر
+
+292
+00:22:54,000 --> 00:22:57,980
+الآيات أو يقرأ .. يجوز لكن من باب الأدب إذا أراد
+
+293
+00:22:57,980 --> 00:23:02,540
+أن يعني يحصل أجر و ثواب عظيم أن يستقبل القبلة
+
+294
+00:23:02,540 --> 00:23:05,240
+الشرّيفة و يكون طاهر البدن و الثوب و المكان و يعظم
+
+295
+00:23:05,240 --> 00:23:09,840
+كلام الله عز وجل و يعني .. و يقرأ القرآن بصوت حسن
+
+296
+00:23:09,840 --> 00:23:16,060
+و هكذا طيب .. أدب آخر يا أخوات أن يستشعر بأنه
+
+297
+00:23:16,060 --> 00:23:20,460
+مخاطب بكل آية يقرأ صحيح عبد الله بن مسعود ماذا
+
+298
+00:23:20,460 --> 00:23:23,620
+يقول؟ يقول عبد الله بن مسعود رضي الله عنه إذا 
+
+299
+00:23:23,620 --> 00:23:28,820
+سمعت الله يقول يا أيها الذين آمنوا فرّغ لها سمعك فإما
+
+300
+00:23:28,820 --> 00:23:34,440
+فرّغ لها سمعك فإنه خير يأمرك الله به أو شر ينهاك الله
+
+301
+00:23:34,440 --> 00:23:38,600
+عنهم إما أن يكون خير ربنا بيأمرك به أو شر ربنا
+
+302
+00:23:38,600 --> 00:23:42,280
+ينهاك عنهم لذلك دائما يا أخوات إذا سمعنا يا أيها
+
+303
+00:23:42,280 --> 00:23:47,500
+الذين آمنوا من الذين آمنوا؟ نحن يا أيها الذين آمنوا
+
+304
+00:23:47,500 --> 00:23:51,160
+يعني انتبه زي ما واحد ينادي عليك يا فلان انتبه،
+
+305
+00:23:51,160 --> 00:23:55,540
+إيش اللي بعدها؟ بعدها إما أن يأمرنا بخير يأمرنا 
+
+306
+00:23:55,540 --> 00:23:59,580
+الله به أو شر ينهاك الله عنه، يأمرنا بخير يا أيها
+
+307
+00:23:59,580 --> 00:24:03,980
+الذين آمنوا أقيموا الصلاة، آتوا الزكاة، يعني
+
+308
+00:24:03,980 --> 00:24:07,340
+انفقوا كفّارة و أوزار وغير ذلك من الآيات اللي فيها
+
+309
+00:24:07,340 --> 00:24:11,860
+أوامر، يبقى الأوامر إلينا أو شر لا تقربوا الصلاة و
+
+310
+00:24:11,860 --> 00:24:16,520
+أنتم سكارى لا تفعلوا كذا و كذا فهي ينهانا عن شر و
+
+311
+00:24:16,520 --> 00:24:19,760
+الله عز و جل العظيم و لا يأمرنا إلا بخير و لا
+
+312
+00:24:19,760 --> 00:24:24,080
+ينهانا إلا .. إلا عن شر و نحن نسمع و نطيع لأمر
+
+313
+00:24:24,080 --> 00:24:26,800
+الله سبحانه و تعالى و الله عز و جل يقول لنا يا
+
+314
+00:24:26,800 --> 00:24:31,180
+أيها الذين آمنوا أطيعوا الله و أطيعوا الرسول نطيع
+
+315
+00:24:31,180 --> 00:24:34,500
+الله بأوامره و نطيع الرسول لأن الرسول عليه الصلاة
+
+316
+00:24:34,500 --> 00:24:39,700
+و السلام جاء بالسنة والسنة هي المصدر الثاني من 
+
+317
+00:24:39,700 --> 00:24:44,520
+مصادر التشريع الإسلامي يعني الرسول عليه الصلاة
+
+318
+00:24:44,520 --> 00:24:49,540
+والسلام يقول لنا ألا إني أوتيت القرآن ومثله معه
+
+319
+00:24:49,540 --> 00:24:53,860
+يعني في عندنا قرآن وفي مثل القرآن معه اللي هي
+
+320
+00:24:53,860 --> 00:24:57,260
+السنة النبوية والسنة النبوية ربنا سبحانه وتعالى
+
+321
+00:24:57,260 --> 00:25:01,780
+يقول لنا لقد كان لكم في رسول الله أسوة حسنة ويقول
+
+322
+00:25:01,780 --> 00:25:06,160
+كذلك وما آتاكم الرسول فخذوه وما نهاكم عنه فانتهوا
+
+323
+00:25:06,160 --> 00:25:11,740
+إذا الرسول بالنسبة لنا هو المعلم والأستاذ والمربي 
+
+324
+00:25:11,740 --> 00:25:16,160
+ورسول الله صلى الله عليه وسلم معلمنا بيبين و بيوضح
+
+325
+00:25:16,160 --> 00:25:19,920
+وبيشرح ما جاء في القرآن الكريم فالسنة هي الموضحة
+
+326
+00:25:19,920 --> 00:25:23,380
+والشارحة والمبينة والمفصلة لما ورد في القرآن
+
+327
+00:25:23,380 --> 00:25:27,200
+الكريم طيب أخوات أدب آخر من أداب تلاوتنا للقرآن
+
+328
+00:25:27,200 --> 00:25:34,530
+الكريم فضل إيه؟ إذا
+
+329
+00:25:34,530 --> 00:25:39,230
+كان بحضرة من يقرأ طبعا يقرأ إما أمامها رجل يقرأ
+
+330
+00:25:39,230 --> 00:25:46,240
+وشيخ أو الإمام أو حتى في مذيع أو حتى في تلفزيون أو 
+
+331
+00:25:46,240 --> 00:25:50,040
+في مسجل أو في جوال أو مكرفون المسجد وهي في البيت 
+
+332
+00:25:50,040 --> 00:25:54,240
+مثلا عليها أن تستمع ربنا سبحانه وتعالى يقول وإذا 
+
+333
+00:25:54,240 --> 00:25:59,500
+قرئ القرآن فاستمعوا له وانصتوا لعلكم ترحمونه ربنا
+
+334
+00:25:59,500 --> 00:26:03,620
+سبحانه وتعالى يرحم الذين يستمعون للقرآن و يخشعون
+
+335
+00:26:03,620 --> 00:26:07,980
+بتلاوتهم للقرآن الكريم أدب آخر يا أخوات فضلي 
+
+336
+00:26:12,520 --> 00:26:18,600
+صحيح يستحب للمستمع للقرآن أو لقارئ القرآن أن يبكي
+
+337
+00:26:18,600 --> 00:26:23,820
+أو يتباكى لأن القرآن نزل بحزن فيه ذكر الجنة وفيه
+
+338
+00:26:23,820 --> 00:26:28,480
+ذكر النار يعني إذا مرت عليه آيات الجنة بكى اشتياقا 
+
+339
+00:26:28,480 --> 00:26:33,160
+للجنة وشوقا لرحمة الله عز وجل وإذا مرت عليه آيات
+
+340
+00:26:33,160 --> 00:26:37,840
+فيها ذكر النار بكى خوفا من النار فالمرء لابد أن
+
+341
+00:26:37,840 --> 00:26:43,670
+يكون بين الخوف و بين الرجاء أدب آخر يا إخوان ..
+
+342
+00:26:43,670 --> 00:26:47,670
+فضليه .. ألا يخلط القارئ بين القراءات والروايات
+
+343
+00:26:47,670 --> 00:26:52,230
+والطرق وعليه أن يتعلم قراءة معينة متصلة برسول الله
+
+344
+00:26:52,230 --> 00:26:55,370
+صلى الله عليه وسلم صحيح ألا يخلط القارئ بين
+
+345
+00:26:55,370 --> 00:26:59,610
+القراءات والروايات والطرق طبعا في عندنا قراءات ..
+
+346
+00:26:59,610 --> 00:27:05,290
+آه في عندنا قراءات يعني في ابن مجاهد ألف كتاب
+
+347
+00:27:05,290 --> 00:27:08,290
+الحجة في القراءات السبع أو السبعة .. السبعة في 
+
+348
+00:27:08,290 --> 00:27:13,440
+القراءات وكذلك في هناك تحفظ رأي البشر في القراءات 
+
+349
+00:27:13,440 --> 00:27:16,340
+الـ 14 في عندنا النشر في القراءات العشر إذا
+
+350
+00:27:16,340 --> 00:27:21,680
+في عندنا سبع قراءات متواترة وزيد عليها كمان ثلاث
+
+351
+00:27:21,680 --> 00:27:25,140
+قراءات متواترة هناخدها إن شاء الله صار عندنا عشر 
+
+352
+00:27:25,140 --> 00:27:28,760
+قراءات متواترة والقراءات المتواترة يا أخوات كلها
+
+353
+00:27:28,760 --> 00:27:33,620
+قرآن يصح لنا أن نقرأ بها ونتعبد الله بها لا نفرض
+
+354
+00:27:33,620 --> 00:27:37,120
+القراءة على قراءة لا نقول والله قراءة حفظ عن عاصم
+
+355
+00:27:37,120 --> 00:27:41,080
+أفضل من قراءة ورش عن نافع فنحن نقرأ بهذه القراءة
+
+356
+00:27:41,080 --> 00:27:45,620
+ونصلّي بها ونتمتع ونستمتع بقراءة القرآن بقراءة حفص 
+
+357
+00:27:45,620 --> 00:27:50,620
+عن عاصم وغيرنا يقرأ بقراءة ورش عن نافع فنحن نقرؤهم
+
+358
+00:27:50,620 --> 00:27:55,440
+وهم يقرؤوننا وكله قرآن و هناك أربع قراءات ثانية 
+
+359
+00:27:55,440 --> 00:27:59,180
+صحيحة يعني ليست متواترة ولم تنطبق عليها شروط
+
+360
+00:27:59,180 --> 00:28:03,960
+التواتر لكنها صحيحة تؤخذ في التفسير زي مثلا وكان
+
+361
+00:28:03,960 --> 00:28:10,020
+وراءهم ملك يأخذ كل سفينة صالحة غصبا يعني كلمة صالحة 
+
+362
+00:28:10,020 --> 00:28:15,960
+مش موجودة عندنا تسمى تفسيريا أو وكان أمامهم مش 
+
+363
+00:28:15,960 --> 00:28:20,800
+وراءهم وكان أمامهم ملكهم فتفسر الآية إنه لم يكن
+
+364
+00:28:20,800 --> 00:28:24,160
+الملك الظالم الذي كان يأخذ السفينة وراءهم وإنما 
+
+365
+00:28:24,160 --> 00:28:27,760
+كان أمامهم لأن السفينة تسير إلى الأمام ولا ترجع
+
+366
+00:28:27,760 --> 00:28:31,950
+إلى الوراء تسير إلى الأمام ف الآيات بتفسر بعضها
+
+367
+00:28:31,950 --> 00:28:37,150
+بعض فكان أمامهم في الأمام و بعدين الملك ياخذ كل
+
+368
+00:28:37,150 --> 00:28:42,630
+سفينة على جنب ولا كل سفينة صالحة كل سفينة صالحة
+
+369
+00:28:42,630 --> 00:28:48,190
+فالخضر عندما خلق السفينة لمصلحة أهل السفينة ولا
+
+370
+00:28:48,190 --> 00:28:53,880
+ليست لمصلحتهم لمصلحتهم لأنه لو لم يخرقها لأخذها 
+
+371
+00:28:53,880 --> 00:28:58,940
+الملك لكنه لما خرقها رفضها الملك فأصلحوها بعد أن
+
+372
+00:28:58,940 --> 00:29:03,260
+رجعوا إلى بيوتهم لذلك لأنها كانت مساكين فيعني
+
+373
+00:29:03,260 --> 00:29:08,360
+خرقها و ذلك لأنه أوتيها من علم الله عز وجل لدنه
+
+374
+00:29:08,360 --> 00:29:12,640
+طيب يعني القراءات لا يخلط بين القراءات يعني ما
+
+375
+00:29:12,640 --> 00:29:17,570
+بنفعل الإمام مثلا أن يقرأ أثناء الصلاة الواحدة يخلط
+
+376
+00:29:17,570 --> 00:29:20,970
+ما بين قراءة ورش عن نافع، حفص عن عاصم، الدوري عن
+
+377
+00:29:20,970 --> 00:29:24,490
+أبي عمر، مثلا كذا و كذا من القراءات، لا يصح أن
+
+378
+00:29:24,490 --> 00:29:28,250
+يقرأ .. لابد أن يقرأ قراءة واحدة، وإذا أراد أن 
+
+379
+00:29:28,250 --> 00:29:35,090
+يغيّر .. يغيّر مثلا .. يقرأ أمام الناس بقراءة ورش عن
+
+380
+00:29:35,090 --> 00:29:39,600
+نافع، نحن أهل الشام نقرأ بقراءة إيش؟ حفص عن عاصم 
+
+381
+00:29:39,600 --> 00:29:44,740
+يعني مثلا مالك يوم الدين هكذا قرأت حفص عن عاصم في
+
+382
+00:29:44,740 --> 00:29:49,780
+قراءة ورش عن نافع مالك يوم الدين لو جاء إمام وقرأ
+
+383
+00:29:49,780 --> 00:29:56,040
+وغيّر بعض الألفاظ لأنه القراءة بتتغير بعض الإمالة و
+
+384
+00:29:56,040 --> 00:30:00,680
+التفخيم و الترقيق وغيرها لو قال الإمام مالك يوم
+
+385
+00:30:00,680 --> 00:30:03,600
+الدين عندنا دون أن يعلم الناس أن أنا أريد أن أقرأ
+
+386
+00:30:03,600 --> 00:30:09,080
+بقراءة ورش عن نافع يظنوا الناس بأن القارئ قد أخطأ
+
+387
+00:30:09,080 --> 00:30:13,680
+فيردونه فيقول إن والله مالك يوم الدين مش عارف
+
+388
+00:30:13,680 --> 00:30:16,840
+القراءة؟ مالك يوم الدين هي .. وليس ملك مع أنه 
+
+389
+00:30:16,840 --> 00:30:21,080
+قراءات مالك وملك كلا هما إيه قراءات يعني صحيحة
+
+390
+00:30:21,080 --> 00:30:24,320
+فلوضع أن يقرأ إلا إذا كان في مقام التعليم يعني في
+
+391
+00:30:24,320 --> 00:30:30,460
+عندنا مثلا درسا نعلّم طلاب أوجه القراءات هي جزء لنا 
+
+392
+00:30:30,460 --> 00:30:35,200
+أن نستعرض أوجه الاختلاف في القراءات نقول مثلا مالك
+
+393
+00:30:35,200 --> 00:30:43,300
+يوم الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم 
+
+394
+00:30:43,300 --> 00:30:44,900
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+395
+00:30:44,900 --> 00:30:45,800
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+396
+00:30:45,800 --> 00:30:48,000
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+397
+00:30:48,000 --> 00:30:55,340
+الدين، ملك يوم الدين، ملكة مالك قراءتين متواترتين
+
+398
+00:30:55,340 --> 00:31:01,660
+وقراءتين شاذتين غير متواترتين ممكن يعني لا يصح بها
+
+399
+00:31:01,660 --> 00:31:07,840
+آخر أدب من أداب التلاوة أشهر بنات فضل أختك على
+
+400
+00:31:07,840 --> 00:31:11,420
+المرء أن يرجو بالتلاوات وجه دراسة عالم وما عندهم 
+
+401
+00:31:11,420 --> 00:31:16,400
+الدراجة والتوافرة بتاعة النبياه والصمعة صحيح أنت
+
+402
+00:31:16,400 --> 00:31:20,500
+مهم جدا لابد أن نقرأ القرآن نبتدي من وراء قراءتنا 
+
+403
+00:31:20,500 --> 00:31:23,670
+القرآن إيش يا أخوات؟ واجه الله سبحانه وتعالى لا
+
+404
+00:31:23,670 --> 00:31:29,370
+نريده مالا ولا نريده سمعة ولا رياء لأن الله سبحانه
+
+405
+00:31:29,370 --> 00:31:33,670
+وتعالى لا يقبل أو لا يقبل أن يشرك به أحد ولابد أن
+
+406
+00:31:33,670 --> 00:31:36,930
+نبتغي من وراء قراءتنا واجه الله عز وجل فمن قرأ 
+
+407
+00:31:36,930 --> 00:31:40,470
+القرآن حتى يأخذ الأجر في نهاية القراءة هذا لا يحصل
+
+408
+00:31:40,470 --> 00:31:44,630
+الأجر من عند الله عز وجل لأنه أخذ الأجر من الناس
+
+409
+00:31:44,630 --> 00:31:48,270
+فالله سبحانه وتعالى أغنى الأغنياء عن الشرك لذلك
+
+410
+00:31:48,270 --> 00:31:57,170
+نبتغي من الله الأجر والثواب على هذه التلاوة ننتقل
+
+411
+00:31:57,170 --> 00:32:02,730
+يا أخوات إلى نقطة أخرى وهي نشأة علم التجويد أنهينا
+
+412
+00:32:02,730 --> 00:32:07,330
+الآن أداب تلاوة القرآن الكريم وقبلها فضل تلاوة
+
+413
+00:32:07,330 --> 00:32:11,810
+القرآن الكريم لو .. لو أردنا أن نأتي بسؤال ممكن
+
+414
+00:32:11,810 --> 00:32:17,010
+نقول عرفي القرآن الكريم ثم بيني دليلا يبين فضل
+
+415
+00:32:17,010 --> 00:32:21,930
+تلاوة القرآن الكريم ثم اذكري خمسا من أداب تلاوة
+
+416
+00:32:21,930 --> 00:32:26,270
+القرآن الكريم بهذا الشكل سؤال متكامل حتى نحصل 
+
+417
+00:32:26,270 --> 00:32:31,970
+الدرجات المناسبة النقطة الثانية يا أخوات متى أنشأ
+
+418
+00:32:31,970 --> 00:32:38,350
+علم التجويد؟ آه .. إيش شميني على .. فضلي .. إذا
+
+419
+00:32:38,350 --> 00:32:41,070
+أنشأ علم التجويد منذ اللحظة التي نزل فيها القرآن
+
+420
+00:32:41,070 --> 00:32:45,350
+الكريم على رسول صلى الله عليه وسلم .. أحسنته ..
+
+421
+00:32:45,350 --> 00:32:50,970
+إذا يا أخوات، حقيقة أول علم من علوم القرآن كان علم
+
+422
+00:32:50,970 --> 00:32:55,870
+.. علم التجويّد لأنه نزل منذ أو كان منذ اللحظة
+
+423
+00:32:55,870 --> 00:32:59,370
+الأولى التي نزل فيها القرآن على الرسول عليه الصلاة 
+
+424
+00:32:59,370 --> 00:33:02,950
+والسلام كان جبريل يلقي النبي عليه الصلاة والسلام 
+
+425
+00:33:02,950 --> 00:33:07,070
+القرآن مجودًا، والرسول عليه الصلاة والسلام يعلمه 
+
+426
+00:33:07,070 --> 00:33:10,890
+للصحابة مجودًا، والصحابة يتناقلونه بينهم ويعلمونه 
+
+427
+00:33:10,890 --> 00:33:16,150
+للتابعين أيضًا مجودًا، فكان التجويّد العملي أول علم من 
+
+428
+00:33:16,150 --> 00:33:21,610
+علوم القرآن موجودًا لأن نزوله كان منذ اللحظة الأولى
+
+429
+00:33:21,610 --> 00:33:25,990
+لنزل القرآن الكريم، ويعادُّ علم التجويّد أول علم من 
+
+430
+00:33:25,990 --> 00:33:30,910
+علوم القرآن، نشأة طيب لو سألنا سؤال: أيّهما كان قبل 
+
+431
+00:33:30,910 --> 00:33:35,170
+علم التجويّد النظري ولا علم التجويّد العملي؟ احنا 
+
+432
+00:33:35,170 --> 00:33:40,590
+ممكن نقول عندما نتعلم نحن أول شيء نتعلم نظريًّا بعدين
+
+433
+00:33:40,590 --> 00:33:45,210
+عمليًّا، لكن من حيث النشأة أيّهما كان قبل العملي ولا
+
+434
+00:33:45,210 --> 00:33:48,770
+النظري؟ فضل. نقطة التجويّد العملي نشأ قبل التجويّد
+
+435
+00:33:48,770 --> 00:33:52,610
+النظري لأن القرآن نزل مجودًا من جبريل على قلب رسول
+
+436
+00:33:52,610 --> 00:33:56,700
+الله، وقام الرسول بعد ذلك بالتعامل مع الصحابة المجاورة
+
+437
+00:33:56,700 --> 00:34:00,480
+ممتاز، إذا التجويّد العملي كان قبل التجويّد النظري
+
+438
+00:34:00,480 --> 00:34:06,060
+ثم بعد مائة سنة أخذ العلماء يستنبطون من التجويّد
+
+439
+00:34:06,060 --> 00:34:11,080
+العملي، يعني أحكامًا معينة حتى وصل إلى العلم الذي نحن
+
+440
+00:34:11,080 --> 00:34:15,120
+فيه وهو علم التجويّد النظري، إذا التجويّد العملي كان
+
+441
+00:34:15,120 --> 00:34:18,120
+مقدمًا على تجويّد النظري، الرسول عليه الصلاة والسلام
+
+442
+00:34:18,120 --> 00:34:22,540
+كان يعلمه للصحابة عمليًّا لأنه كان يستقبله من جبريل
+
+443
+00:34:22,540 --> 00:34:27,060
+مجودًا يعلمه للصحابة مجودًا، الصحابة كانوا يعلمونه 
+
+444
+00:34:27,060 --> 00:34:31,160
+للتابعين مجودًا، والتابعون يعلمونه لأتباع التابعين 
+
+445
+00:34:31,160 --> 00:34:35,760
+وهكذا مجودًا إلى أن وصل القرآن، فالقرآن يؤخذ
+
+446
+00:34:35,760 --> 00:34:45,610
+بمشافهة و بالتلقّي. طيب، لكن متى بدأ تدوين علم التجويّد؟
+
+447
+00:34:45,610 --> 00:34:51,390
+اه، تفضلي. اختكفي القرن الثاني للهجرة بدأ تدوين علم
+
+448
+00:34:51,390 --> 00:34:55,770
+التجويّد حيث بدأ عصر التدوين، يعني في عهد عمرو بن 
+
+449
+00:34:55,770 --> 00:35:00,470
+عبد العزيز بدأ يدوِّن السنة ويجمع الأحاديث لأن 
+
+450
+00:35:00,470 --> 00:35:05,050
+الصحابة رضي الله عنهم أصبحوا يعني ممكن يفقدوا
+
+451
+00:35:05,050 --> 00:35:09,490
+ويموتوا واحدًا والآخر، فكان الصحابة العلماء بحاجة 
+
+452
+00:35:09,490 --> 00:35:12,250
+إلى أن يجمعوا أحاديث النبي عليه الصلاة والسلام 
+
+453
+00:35:12,250 --> 00:35:16,730
+ويجمعوا العلوم، وكان من ضمن العلوم التي جمعوها 
+
+454
+00:35:16,730 --> 00:35:22,230
+بداية تدوين لعلم التجويّد، ولكن يعني علم التجويّد بعض 
+
+455
+00:35:22,230 --> 00:35:25,970
+العلماء بدأ في علوم معينة، يعني علم التجويّد يعني
+
+456
+00:35:25,970 --> 00:35:30,970
+يتحدث عن أو يستنبط أحكام التجويّد من قراءة الرسول
+
+457
+00:35:30,970 --> 00:35:34,710
+بعلم معين، يعني بعضهم استنبط أحكام الهمزة الساكنة
+
+458
+00:35:34,710 --> 00:35:38,230
+والنون الساكنة، بعضهم استنبط مخارج الحروف، بعضهم استنبط
+
+459
+00:35:38,230 --> 00:35:42,360
+مثلًا أحكام المدّ، بعضهم التفخيم والترقيق وهكذا...
+
+460
+00:35:42,360 --> 00:35:47,820
+ولذلك اختلف من هو أول من صنّف في علوم التجويّد
+
+461
+00:35:47,820 --> 00:35:52,540
+والصحيح أنه كلّ... كل واحد بذل مجهودًا، كان من أول من 
+
+462
+00:35:52,540 --> 00:35:55,800
+صنف في علم التجويّد، هنا أول من دوّن في علم التجويّد
+
+463
+00:35:55,800 --> 00:36:01,340
+هو قيل إنه أبو الأسود الدؤلي، وقيل إنه الخليل بن
+
+464
+00:36:01,340 --> 00:36:05,980
+أحمد الفراهيدي، وقيل أبو عبيد القاسم بن سلام، وقيل 
+
+465
+00:36:05,980 --> 00:36:12,980
+غيرهم، لكن الصواب ممكن نقول كلهم لهم إيش؟ لهم يعني
+
+466
+00:36:12,980 --> 00:36:17,200
+مكانة في عملية التدوين أو التجويّد، لأنه كل واحد 
+
+467
+00:36:17,200 --> 00:36:22,720
+يعني صنّف واجتهد وأظهر علمًا في علم التجويّد، لكن بعد
+
+468
+00:36:22,720 --> 00:36:26,660
+ذلك أخذ العلماء يجمعون هذه العلوم، يعني أول من بدأ
+
+469
+00:36:26,660 --> 00:36:31,720
+يفكّر في تدوين علم التجويّد ويستنبطه اللي هو أبو
+
+470
+00:36:31,720 --> 00:36:36,960
+الأسود الدؤلي وغيرهم، بعد ذلك بعد مائة سنة ولا متى 
+
+471
+00:36:36,960 --> 00:36:40,960
+سنة أصبح العلماء يعني يجمعون هذه العلوم في كتب
+
+472
+00:36:40,960 --> 00:36:45,880
+مستقلة، منهم مكيّ بن أبي طالب الذي توفي سنة أربعمائة
+
+473
+00:36:45,880 --> 00:36:51,420
+وسبع وثلاثين من الهجرة ألف كتاب اسمه الرعاية
+
+474
+00:36:51,420 --> 00:36:56,240
+لتجويّد القراءة وتحقيق لفظ التلاوة، كتاب جمع فيه ما 
+
+475
+00:36:56,240 --> 00:37:01,540
+استنبطه العلماء في كتاب واحد، ثمّ أبو عمر الدانيّ 
+
+476
+00:37:01,540 --> 00:37:07,940
+الذي توفي سنة 444 من الهجرة ألف كتاب اسمه التحديد
+
+477
+00:37:07,940 --> 00:37:12,440
+في علم الإتقان والتجويد، كذلك ابن الجزري محمد بن
+
+478
+00:37:12,440 --> 00:37:18,760
+الجزري الذي توفي سنة 833، يعني بعد 800 سنة، ألف كتاب
+
+479
+00:37:18,760 --> 00:37:21,420
+اسمه التمهيد في علم التجويّد، وكذلك ابن الْلّه 
+
+480
+00:37:21,420 --> 00:37:26,200
+الجزرية، اللي هو جمع علم التجويّد بقصيدة من باب
+
+481
+00:37:26,200 --> 00:37:30,360
+التسهيل في علم التجويّد وهي موجودة الآن، كذلك الشيخ 
+
+482
+00:37:30,360 --> 00:37:34,380
+سليمان الجمزوري المولود سنة ألف ومئة وثلاثة وتسعين 
+
+483
+00:37:34,380 --> 00:37:38,460
+من الهجرة نظّم شعرًا وسماه تحفة، تحفة الأطفال
+
+484
+00:37:38,830 --> 00:37:42,970
+تحفة الأطفال، يعني نظمه شعرًا يجمع علم التجويز في
+
+485
+00:37:42,970 --> 00:37:47,270
+قصيدة سهلة كان يحفظها مين؟ الأطفال، لأنه كان
+
+486
+00:37:47,270 --> 00:37:51,490
+الأطفال هم الذين يتعلمون في الكتاتيب ويحفظوا
+
+487
+00:37:51,490 --> 00:37:55,770
+القرآن كمين؟ فكانوا يحفظونه، والذي يحفظ المتون ينال 
+
+488
+00:37:55,770 --> 00:38:00,980
+إيش؟ ينال الفضل. نكتفي نحن بهذا القدر حتى إن شاء 
+
+489
+00:38:00,980 --> 00:38:04,160
+الله نبدأ في المحاضرة القادمة التي هي بعنوان 
+
+490
+00:38:04,160 --> 00:38:08,660
+الحروف السبعة في القرآن الكريم، نحن ندعوكم إلى شراء
+
+491
+00:38:08,660 --> 00:38:12,660
+هذا الكتاب اسمه المغني في علم التجويّد، هذا الكتاب
+
+492
+00:38:12,660 --> 00:38:16,140
+معكم هو هيكون المقرر بإذن الله عز وجل بالإضافة 
+
+493
+00:38:16,140 --> 00:38:19,060
+لهذه المادة، طبعًا المادة موجودة في صفحة صفحة 
+
+494
+00:38:19,060 --> 00:38:23,600
+المدرسين، صفحة أنا بمكان كل طالبة أن تفتح على صفحة
+
+495
+00:38:23,600 --> 00:38:28,310
+المدرس زهد أبو نعمة وتدخل على الموقع وتأخذ المادة
+
+496
+00:38:28,310 --> 00:38:32,730
+نفسها وهي وجميع المواد، وهناك أسئلة كثيرة وفي فائدة 
+
+497
+00:38:32,730 --> 00:38:35,530
+عظيمة إن شاء الله سوف تجدونها في الموقع، بارك الله 
+
+498
+00:38:35,530 --> 00:38:39,390
+فيكم، والسلام عليكم، ابقوا مكانكم يا أخوات.
+
+499
+00:38:44,360 --> 00:38:49,560
+يا أخواتي احنا عندنا طالبات وبناخد حضور وغياب اليوم
+
+500
+00:38:49,560 --> 00:38:52,920
+مش راح ناخد حضور وغياب لأن أول محاضرة لكن في
+
+501
+00:38:52,920 --> 00:38:55,640
+المحاضرة القادمة، الأسبوع القادم هنبدأ في حضور و
+
+502
+00:38:55,640 --> 00:39:00,670
+غياب، الحضور والغياب عليه عشر درجات، عشان الدرجات هو
+
+503
+00:39:00,670 --> 00:39:04,850
+والـ quizzes هنعطيكم في خلال الفصل quizين، يعني كل
+
+504
+00:39:04,850 --> 00:39:09,950
+ثلاث أسابيع quiz، وquiz قبل الامتحان النصفي، وquiz
+
+505
+00:39:09,950 --> 00:39:13,030
+بعد الامتحان النصفي، على أساس نكون... يعني ندرس 
+
+506
+00:39:13,030 --> 00:39:16,690
+للامتحان النصفي، طبعًا الامتحان عليه درجتين، ندرس 
+
+507
+00:39:16,690 --> 00:39:24,500
+لدرجتين، سهل جدًا، لكن ايه؟ عشان لو قدمنا الامتحان
+
+508
+00:39:24,500 --> 00:39:28,040
+النصفي عليه عشانين درجة، نكون قرينا المادة لأن بعض
+
+509
+00:39:28,040 --> 00:39:31,940
+الأخوات لا يقرؤون إلا إيش؟ إلا للامتحان، فنحن نريد
+
+510
+00:39:31,940 --> 00:39:35,840
+أن نقرأ قراءتين: قراءة قبل الامتحان باسبوعين، يعني 
+
+511
+00:39:35,840 --> 00:39:39,300
+قبل ما تبدأ الامتحانات نكون احنا خلصنا جزء من
+
+512
+00:39:39,300 --> 00:39:43,480
+المقرر، قررنا حتى إذا أخذنا الامتحان النصفي نكون
+
+513
+00:39:43,480 --> 00:39:46,020
+جارينا عدد كبير، كذلك الامتحان النهائي... قبل ما 
+
+514
+00:39:46,020 --> 00:39:49,460
+ناخد الامتحان النهائي ناخد كمان quiz، حتى نأتي للامتحان 
+
+515
+00:39:49,460 --> 00:39:53,400
+النهائي ونكون ايش يا أخوات... مخدين النصف الثاني
+
+516
+00:39:53,400 --> 00:39:57,020
+ونفهم القرآن لأن احنا نفتخر فيكم ونريد منكم
+
+517
+00:39:57,020 --> 00:39:59,560
+جميعًا أن تحصلوا أعلى درجات، وبارك الله فيكم، و
+
+518
+00:39:59,560 --> 00:40:00,060
+السلام عليكم. 
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..92f1a20ae994e94a8abd66508b778376e2d05810
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/gdgjj9Eem1w_postprocess.srt
@@ -0,0 +1,2072 @@
+1
+00:00:13,420 --> 00:00:16,600
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+2
+00:00:16,600 --> 00:00:21,180
+الرحيم الحمد لله وصلة والسلام على رسول الله وعلى
+
+3
+00:00:21,180 --> 00:00:26,690
+آله وصحبه وسلمنراحبكم في بداية الفصل الدراسي
+
+4
+00:00:26,690 --> 00:00:31,050
+الجديد سنكون معكم ان شاء الله يا أخوات في متطلب
+
+5
+00:00:31,050 --> 00:00:34,330
+ومساق من المساقات للجامعة الأسلامية اللي هو
+
+6
+00:00:34,330 --> 00:00:39,970
+التلاوة والتجبيد المطلوب معناه في هذا الفصل هو هذا
+
+7
+00:00:39,970 --> 00:00:44,730
+الكتاب كتاب المغني في علم التجبيد كتاب للدكتور عبد
+
+8
+00:00:44,730 --> 00:00:50,260
+الرحمن الجمل كتاب ان يتحدث عن التلاوة والتجبيدمن
+
+9
+00:00:50,260 --> 00:00:54,940
+صفحة واحد إلى صفحة 256 سنأخده إن شاء الله و نسعى
+
+10
+00:00:54,940 --> 00:00:59,260
+بإذن الله عز وجل إلى أن ننتهي من هذا المقرر نطلب
+
+11
+00:00:59,260 --> 00:01:03,620
+من هذا الكتاب بالنسبة لتوزيع الدرجات هيكون في عنا
+
+12
+00:01:03,620 --> 00:01:07,340
+عشر درجات بإذن الله عز وجل على الحضور والغياب
+
+13
+00:01:07,340 --> 00:01:12,820
+والمناقشة والمشاركة في المحاضرة وعندنا عشرين درجة
+
+14
+00:01:12,820 --> 00:01:18,570
+على الامتحان النصفيو كذلك اربعين درجة على الامتحان
+
+15
+00:01:18,570 --> 00:01:24,910
+النهائي يعني عشرة وعشرين واربعين تقريبا سبعين درجة
+
+16
+00:01:24,910 --> 00:01:29,110
+.. سبعين درجة و هم اللي إلي أنا كمدرس للمادة
+
+17
+00:01:29,110 --> 00:01:34,430
+النظرية و في تلاتين درجة للعمل هناك إحدى الأخوات
+
+18
+00:01:34,430 --> 00:01:39,470
+سوف تأتي عندكم و تدرسكم اللي هي المادة العملية
+
+19
+00:01:39,470 --> 00:01:44,190
+تتلونها أنا عليا التدريس النظريو الأخت سوف تدرسكم
+
+20
+00:01:44,190 --> 00:01:48,510
+بإذن الله تعالى تدريس عمل الاتلاوة يعني تقرأ قرآن
+
+21
+00:01:48,510 --> 00:01:53,590
+وتطبق الأحكام التي أختموها على هذه الآيات القرأنية
+
+22
+00:01:53,590 --> 00:01:57,710
+سأكون معكم في هذا الفصل الدكتور زهدي أبو نعمة
+
+23
+00:01:57,710 --> 00:02:01,790
+المادة اللي معناها هي التلاوة والتجويت الموضوع
+
+24
+00:02:01,790 --> 00:02:06,290
+الأول يا أخوات ان شاء الله هو فضل اتلاوه و آدابه
+
+25
+00:02:07,390 --> 00:02:10,630
+والموضوع اللي سوف ندرسه نحن اللي هو تعريف القرآن
+
+26
+00:02:10,630 --> 00:02:15,190
+الكريم وما يتعلق بالقرآن الكريم واداب التلاوة وما
+
+27
+00:02:15,190 --> 00:02:20,150
+يتعلق بالقرآن الكريم من يعرف لنا القرآن الكريم؟
+
+28
+00:02:20,150 --> 00:02:25,370
+قدري اخو الكريم هو كل و لو الله المنظر على محمد
+
+29
+00:02:25,370 --> 00:02:28,560
+صلى الله عليه وسلمالمنقول لين بالتواتر المتعبد
+
+30
+00:02:28,560 --> 00:02:31,320
+بتلاوته و المبدوء بصورة الفادحة و المفتوم بصورة
+
+31
+00:02:31,320 --> 00:02:34,240
+الناس صحيح القرآن الكريم يا أخوات هو كلام الله
+
+32
+00:02:34,240 --> 00:02:39,000
+المعجز المنزل على محمد صلى الله عليه وسلم المنقول
+
+33
+00:02:39,000 --> 00:02:42,840
+لين بالتواتر المتعبد بتلاوته و المبدوء بصورة
+
+34
+00:02:42,840 --> 00:02:47,350
+الفادحة و المفتوم بصورة الناسكلام الله قال كلام
+
+35
+00:02:47,350 --> 00:02:51,210
+الله حتى نميز كلام الله عن كلام غيره، هناك كلام
+
+36
+00:02:51,210 --> 00:02:55,510
+للملائكة، كلام للإنس، كلام للجن، فكلام الله وكلام
+
+37
+00:02:55,510 --> 00:02:59,490
+الله عز وجل إيش؟ معجز، ربنا سبحانه وتعالى جعل
+
+38
+00:02:59,490 --> 00:03:03,710
+رسالة محمد صلى الله عليه وسلم رسالة خالدة، والقرآن
+
+39
+00:03:03,710 --> 00:03:07,010
+أو معجزة الرسول عليه الصلاة والسلاممعجزة خالدة و
+
+40
+00:03:07,010 --> 00:03:12,030
+هي القرآن الكريم فهو معجز ببيانه و الفاظه و معانيه
+
+41
+00:03:12,030 --> 00:03:15,770
+فهو كلام الله المعجز و ربنا سبحانه و تعالى تحدى
+
+42
+00:03:15,770 --> 00:03:20,350
+الإنس و الجن أن يأتوا بمثل هذا القرآن فعجزوا فقال
+
+43
+00:03:20,350 --> 00:03:24,810
+تعالى كل إن اجتمعت الإنس و الجن على أن يأتوا بمثل
+
+44
+00:03:24,810 --> 00:03:29,430
+هذا القرآن لا يأتون بمثله و لو كان بعضهم لبعضٍ
+
+45
+00:03:29,430 --> 00:03:34,890
+ظاهرةثم تحدى العرب و هم أهل البلاغة و الفصاحة و
+
+46
+00:03:34,890 --> 00:03:39,070
+البيان تحدهم أن يأتوا بصورة واحدة من مثله فعجزوا
+
+47
+00:03:39,070 --> 00:03:43,950
+اشرب الله سبحانه و تعالى يقول وإن كنتم في ريب مما
+
+48
+00:03:43,950 --> 00:03:49,250
+نزلنا على عبدنا فاتوا بصورة من مثله وادعوا شهداءكم
+
+49
+00:03:49,250 --> 00:03:54,430
+من دون الله إن كنتم صادقين فعجزوا فالقرآن معجز
+
+50
+00:03:54,430 --> 00:04:00,510
+ببيانه وبلاغته وفصاحته ومعانيه وغير ذلكالمنزل على
+
+51
+00:04:00,510 --> 00:04:04,530
+محمد صلى الله عليه وسلم لماذا قلنا المنزل على
+
+52
+00:04:04,530 --> 00:04:11,690
+محمد؟ لأن هناك كتب أنزلت على غير محمد هناك التوراة
+
+53
+00:04:11,690 --> 00:04:16,650
+أنزلت على مين؟ على سيدنا موسى الإنجيل على سيدنا
+
+54
+00:04:16,650 --> 00:04:22,430
+عيسى الزبور على سيدنا داود الصحف على سيدنا محمد
+
+55
+00:04:22,430 --> 00:04:26,390
+وهناك كتب أخرى أنزلت على أنبياء لم يرد ذكرهم في
+
+56
+00:04:26,390 --> 00:04:31,120
+القرآن لكننا نؤمن بأن هناكأنبياء آخرون وأرسل إليهم
+
+57
+00:04:31,120 --> 00:04:35,620
+الكتب من عند الله عز وجل فهو كلام الله المعجز
+
+58
+00:04:35,620 --> 00:04:40,200
+المنزل على محمد صلى الله عليه وسلم المنقول إلينا
+
+59
+00:04:40,200 --> 00:04:44,220
+بالتواتر ما معنى المنقول إلينا بالتواتر؟
+
+60
+00:04:49,130 --> 00:04:55,410
+صحيح التواتر هو ما نقله جمع عن جمع في كل طبقة من
+
+61
+00:04:55,410 --> 00:04:59,830
+طبقات السند تحيل العادى تواطؤهم على الكلمة يعني
+
+62
+00:04:59,830 --> 00:05:04,130
+الرسول عليه الصلاة والسلام أنزل عليه القرآن فعلّمه
+
+63
+00:05:04,130 --> 00:05:08,990
+لمن؟ للصحابة عدد الصحابة بمجموعه 120 ألف صحابة
+
+64
+00:05:08,990 --> 00:05:14,040
+تقريبا كما يقول العلماءهؤلاء الـ 120 ألف صحابي
+
+65
+00:05:14,040 --> 00:05:18,060
+علمون مين للتابعين أكيد هم هيكونوا أكثر من الـ 120
+
+66
+00:05:18,060 --> 00:05:23,040
+ألف والتابعون علموه لأتباع التابعين و هكذا حتى وصل
+
+67
+00:05:23,040 --> 00:05:27,600
+القرأن إلينا بفضل الله عز وجل ولذلك حتى الآن هناك
+
+68
+00:05:27,600 --> 00:05:31,180
+من الناس من يحملوا السند إلى الرسول عليه الصلاة
+
+69
+00:05:31,180 --> 00:05:34,820
+والسلاميقول مثلا أخذوا القرآن عن فلان، عن فلان، عن
+
+70
+00:05:34,820 --> 00:05:38,340
+فلان إلى الرسول صلى الله عليه وسلم وفي الجامعة
+
+71
+00:05:38,340 --> 00:05:41,760
+الإسلامية في هناك كثير من الطلاب والطالبات وفي غزة
+
+72
+00:05:41,760 --> 00:05:45,840
+من يحمل السند إلى الرسول صلى الله عليه وسلم تبركا
+
+73
+00:05:45,840 --> 00:05:51,460
+أن نفسه اتصل بنفس الرسول عليه الصلاة والسلامإذا
+
+74
+00:05:51,460 --> 00:05:56,300
+وصل القرآن إلينا متواتر جيل عن جيل بلغون هذا
+
+75
+00:05:56,300 --> 00:06:02,220
+القرآن مشافهة ووصلنا كذلك مكتوبا على الصحفة إذا
+
+76
+00:06:02,220 --> 00:06:05,920
+المنقل إلينا بالتواتر المتعبد بتلاوته ما معنى
+
+77
+00:06:05,920 --> 00:06:07,920
+أخوات المتعبد بتلاوته؟
+
+78
+00:06:10,150 --> 00:06:14,150
+يعني نحن نتعبد الله بتلاوتنا للقرآن الكريم نصلي
+
+79
+00:06:14,150 --> 00:06:18,610
+فنقرأ القرآن وإذا أردنا أن نحصل الأجر نقرأ القرآن
+
+80
+00:06:18,610 --> 00:06:23,830
+تعبدًا والرسول عليه الصلاة والسلام يقول لنا من قرأ
+
+81
+00:06:23,830 --> 00:06:29,170
+حرف من كتاب الله تعالى له بيه حسنة والحسنة بعشر
+
+82
+00:06:29,170 --> 00:06:34,450
+أمثالها لا أقول ألف لم من حرف ولكن ألف حرف ولم حرف
+
+83
+00:06:34,450 --> 00:06:39,010
+وم من حرف إذا كل حرف نقرأه من كتاب الله تعالى لنا
+
+84
+00:06:39,010 --> 00:06:45,700
+بيه كام؟عشر حسنات لو كلمة فيها خمس حروف خمسة ضرب
+
+85
+00:06:45,700 --> 00:06:51,880
+عشرة خمسين لو سطر في عشر كلمات بخمسة عشرة ضرب
+
+86
+00:06:51,880 --> 00:06:59,490
+خمسين حسنة بخمسمائة حسنة الصفحة فيهاخمستاشر سطر
+
+87
+00:06:59,490 --> 00:07:04,590
+يعني العدد عشرة ضرب خمسين ضرب خمستاشر بيطلع عدد
+
+88
+00:07:04,590 --> 00:07:09,770
+كبير في الجزء مثلا خمسة وعشرين صفحة بيصير الواحد
+
+89
+00:07:09,770 --> 00:07:14,150
+مليونير حسنات في خلال نص ساعة و هو يقرأ القرآن إذا
+
+90
+00:07:14,150 --> 00:07:18,510
+نحن نتعبد الله سبحانه وتعالى بتلاوتنا للقرآن
+
+91
+00:07:18,510 --> 00:07:23,330
+الكريم طبعا ليه صحه مثلا أن يصلي الإنسان و يقرأ
+
+92
+00:07:23,330 --> 00:07:28,530
+غير القرآن في الصلاة؟ لو قرأ حديث نبويه هل فصح؟ولو
+
+93
+00:07:28,530 --> 00:07:32,730
+حتى يقرأ صحيح البخاري والكتاب الفقه ولا أي شيء لا
+
+94
+00:07:32,730 --> 00:07:36,690
+يصح لنا إلا أن نقرأ القرآن في الصلاة فنحن نتعبد
+
+95
+00:07:36,690 --> 00:07:41,310
+الله في صلاتنا ولنا أجر عظيم في تلاوتنا للقرآن
+
+96
+00:07:41,310 --> 00:07:44,490
+الكريم وهذا القرآن يا أخوات مبدوء بصورة الفاتحة
+
+97
+00:07:44,490 --> 00:07:49,230
+ومختتم بصورة الناس وهو الكتاب الذي هو مكتوب بين
+
+98
+00:07:49,230 --> 00:07:53,790
+أيدينا وللقرآن الكريم فضل في التلاوة الذي يتلو
+
+99
+00:07:53,790 --> 00:07:58,600
+القرآن له أجر عظيم ورد ذلك يا أخوات في الكتابوفي
+
+100
+00:07:58,600 --> 00:08:03,020
+السنة نشوف مثلا في الكتاب مانيذ كلنا آية قرأنية
+
+101
+00:08:03,020 --> 00:08:07,000
+تتحدث عن فضل تلاوة القرآن الكريم طبعا الكلام كله
+
+102
+00:08:07,000 --> 00:08:10,960
+موجود بين أيديكم بإمكانكم أن يعني بس نريد منكم أن
+
+103
+00:08:10,960 --> 00:08:14,480
+تشاركوا في هذه المحاضرة تفضل أخت بسم الله الرحمن
+
+104
+00:08:14,480 --> 00:08:20,280
+الرحيم الذين أتيناهم الكتاب يسلونه حق تلاوته الله
+
+105
+00:08:20,280 --> 00:08:25,300
+تعالىورتّل القرآن ترتيلا أحسنتي الذين آتينهم
+
+106
+00:08:25,300 --> 00:08:30,340
+الكتاب يتلونه حق تلاوته نريد أن نتلو القرآن حق
+
+107
+00:08:30,340 --> 00:08:34,700
+تلاوته والله عز وجل يقول لنا كذلك ورتّل القرآن
+
+108
+00:08:34,700 --> 00:08:40,200
+ترتيلا وكذلك هناك أحاديث نبوية تبين فضل تلاوة
+
+109
+00:08:40,200 --> 00:08:44,720
+القرآن كذلك وأن الذي يتلو القرآن له إيش أخوات؟ له
+
+110
+00:08:44,720 --> 00:08:49,360
+أجر عظيم من يذكر لنا أحاديث نبوية تذل على فضل
+
+111
+00:08:49,360 --> 00:08:50,340
+تلاوة القرآن كذلك
+
+112
+00:08:54,630 --> 00:08:59,650
+صحيح خيركم من تعلم القرآن و علمهم الحديث روا مين؟
+
+113
+00:08:59,650 --> 00:09:05,240
+البخاري ما معنى حديث رواه البخاري؟البخاري يا أخوات
+
+114
+00:09:05,240 --> 00:09:09,440
+هو أصح كتاب بعد كتاب الله تعالى لأن الإمام البخاري
+
+115
+00:09:09,440 --> 00:09:13,240
+اتخذ يعني أسلوبا معينا في انتقاء الأحاديث الصحيحة
+
+116
+00:09:13,240 --> 00:09:17,160
+وكانت الأحاديث الصحيحة كلها بدقة بحيث تكون أحاديث
+
+117
+00:09:17,160 --> 00:09:20,280
+صحيحة مروية عند الرسول صلى الله عليه وسلم فعندما
+
+118
+00:09:20,280 --> 00:09:24,280
+نقول صحيح البخاري نحن على يقين بأن النبي عليه
+
+119
+00:09:24,280 --> 00:09:29,240
+الصلاة والسلام قد قال هذا الكلام وهو خيركم من تعلم
+
+120
+00:09:29,240 --> 00:09:33,970
+القرآن وعلمها حديث أخر يا أخوات، فضليهعن عائشة رضي
+
+121
+00:09:33,970 --> 00:09:37,030
+الله عنه النبي صلى الله عليه وسلم والخان اللذي
+
+122
+00:09:37,030 --> 00:09:42,210
+يقرأ القرآن وهو مع سفرات الكرام البلدان والذي يشتد
+
+123
+00:09:42,210 --> 00:09:46,190
+عليه على أي فرق أجريممتاز، بأيضا حديث رواه مسلم،
+
+124
+00:09:46,190 --> 00:09:49,530
+يعني حديث صحيح رواه مسلم لأنه أصح كتاب بعد كتاب
+
+125
+00:09:49,530 --> 00:09:53,490
+الله البخاري ثم يليه الإمام مسلم، وبعد ذلك كتب
+
+126
+00:09:53,490 --> 00:09:57,550
+السنن الترمذو النسائي وابدود وابن ماجا وغير ذلك من
+
+127
+00:09:57,550 --> 00:10:00,770
+الكتب هنا النبي عليه الصلاة والسلام يبين لنا الأجر
+
+128
+00:10:00,770 --> 00:10:05,210
+الذي يقرأ القرآن وهو ماهر به مع السفرة الكرام
+
+129
+00:10:05,210 --> 00:10:10,120
+البررة من هم السفرة الكرام البررة؟الملائكة يعني
+
+130
+00:10:10,120 --> 00:10:14,520
+بيكون ربنا سبحانه وتعالى رفع درجته ومقداره فهو مع
+
+131
+00:10:14,520 --> 00:10:18,800
+الملائكة لأنه يتلو القرآن وتقرط به إلى الله عز وجل
+
+132
+00:10:18,800 --> 00:10:23,480
+والذي يشتد عليه القرآن فله أجران يعني أو حديث آخر
+
+133
+00:10:23,480 --> 00:10:27,960
+والذي يقرأ القرآن ويتعتق فيه وهو عليه شاق له أجران
+
+134
+00:10:27,960 --> 00:10:32,360
+في رواية أخرىإذا حتى الإنسان الذي لا يستطيع أن
+
+135
+00:10:32,360 --> 00:10:36,420
+يقرأ القرآن أو يجد مشقة في تلاوته القرآن ويتعتع
+
+136
+00:10:36,420 --> 00:10:40,640
+فيه فلا نقول له أنت لا تقرأ لأنك تتعتع في القرآن
+
+137
+00:10:40,640 --> 00:10:46,680
+نقول لك هنيئا لك فإن النبي صلى الله عليه وسلم بشرك
+
+138
+00:10:46,680 --> 00:10:52,650
+بأن لك أجرين لكن عليك أن تقرأ القرآنوتجتهد في تعلم
+
+139
+00:10:52,650 --> 00:10:57,750
+القرآن حتى تكون مثل مين؟ مثل السفرة الكرام البررة
+
+140
+00:10:57,750 --> 00:11:01,370
+وهم الذين يقرؤون القرآن بمهارة حديث أخر يا أخوات
+
+141
+00:11:01,370 --> 00:11:07,350
+فضليه صحيح
+
+142
+00:11:07,350 --> 00:11:12,610
+مظبوط كذا حديث أخر فضليه ما معنى يا أخوات ما لم
+
+143
+00:11:12,610 --> 00:11:19,650
+يتغنى بالقرآن فليس مننايعني يقرأ القرآن بصوت ندي
+
+144
+00:11:19,650 --> 00:11:23,450
+حسن مطبقًا لأحكام التجويض والنبي عليه الصلاة
+
+145
+00:11:23,450 --> 00:11:27,870
+والسلام كان يقرأ القرآن مجودًا بل إن جبريل عليه
+
+146
+00:11:27,870 --> 00:11:31,130
+الصلاة والسلام لما كان ينزل القرآن على محمد كان
+
+147
+00:11:31,130 --> 00:11:34,590
+ينزله مجودًا والرسول صلى الله عليه وسلم يعلمه
+
+148
+00:11:34,590 --> 00:11:38,690
+للصحابة مجودًا والصحابة كانوا يأخذونه مشافهة من
+
+149
+00:11:38,690 --> 00:11:42,070
+الرسول صلى الله عليه وسلم مجودًا ويعلمونه للتابعين
+
+150
+00:11:42,070 --> 00:11:47,680
+فالقرآن يُأخذ بالمشافهة مجودًالذلك لابد أن يحسن
+
+151
+00:11:47,680 --> 00:11:52,060
+الإنسان تلاوته بالقرآن وقد كان النبي عليه الصلاة
+
+152
+00:11:52,060 --> 00:11:56,920
+والسلام يتعرف على بيوت أصحابه من أصواتهم في
+
+153
+00:11:56,920 --> 00:12:01,160
+تلاوتهم للقرآن في الليل فقد ورد أن النبي صلى الله
+
+154
+00:12:01,160 --> 00:12:06,700
+عليه وسلم كان يتفقد أحوال الرعية في الليل فسمع صوت
+
+155
+00:12:06,700 --> 00:12:11,480
+أبي موسى الأشعري وهو في بيته يتلو القرآنفقال له في
+
+156
+00:12:11,480 --> 00:12:14,180
+اليوم الثاني عرف أن هذا البيت هو بيت أبو موسى
+
+157
+00:12:14,180 --> 00:12:17,520
+الأشعر فقال له في اليوم التاني لو رأيتني وأنا
+
+158
+00:12:17,520 --> 00:12:22,600
+أستمع لقرائتك البارحة لقد أوتيت مزمارا من مزامير
+
+159
+00:12:22,600 --> 00:12:27,860
+أهل دول فقال له أبو موسى لو علمت أنك تستمع إليا
+
+160
+00:12:29,010 --> 00:12:36,210
+لحبرته لك تحبيرة يعني ازدادته تحسينا لهذه اتلاعي و
+
+161
+00:12:36,210 --> 00:12:40,530
+قرأته بصوت حسن انا كنت اقل القرآن لنفسي فلو علمته
+
+162
+00:12:40,530 --> 00:12:45,470
+انك تستمع لي لا زدته من جمال القرآن ولا استمتعته
+
+163
+00:12:45,470 --> 00:12:48,490
+طبعا يا أخوات الواحد لما يقرأ القرآن بصوت جمال هو
+
+164
+00:12:48,490 --> 00:12:53,190
+نفسه يشعر باللذةويستمتع ويتغنى بالقرآن لذلك ليس
+
+165
+00:12:53,190 --> 00:12:57,990
+مننا من يتغنى بالقرآن كذلك الحديث الآخر يبين فضل
+
+166
+00:12:57,990 --> 00:13:01,970
+تلاوة القرآن ايش يا أخوان؟ من يقرأ؟ فضلي
+
+167
+00:13:17,990 --> 00:13:22,700
+أحسن طبعا الحديث اللي هو ترمي دي حسن وانصحيمن قرأ
+
+168
+00:13:22,700 --> 00:13:26,180
+حرف من كتاب الله تعالى له به حسنة، والحسنة بعشر
+
+169
+00:13:26,180 --> 00:13:30,380
+أمثالها، لا أقول ألف، لام، ميم حرف، ولكن ألف حرف
+
+170
+00:13:30,380 --> 00:13:34,220
+ولام حرف وميم حرف كذلك يقال كما قال النبي عليه
+
+171
+00:13:34,220 --> 00:13:38,500
+الصلاة والسلام يقال لقارئ القرآن اقرأ ورقة ورتل
+
+172
+00:13:38,500 --> 00:13:43,560
+كما كنت ترتل في الدنيا فإن منزلتك عند آخر آية
+
+173
+00:13:43,560 --> 00:13:46,980
+تقرأهاوحديث أخر يعني يقول النبي عليه الصلاة
+
+174
+00:13:46,980 --> 00:13:52,240
+والسلام من قرأ القرآن وعمل بما فيه ألبس والديه
+
+175
+00:13:52,240 --> 00:13:57,140
+تاجا يوم القيامة ضوءه أحسن من ضوء الشمس فما ظنكم
+
+176
+00:13:57,140 --> 00:14:02,820
+بالذي عمل بهذا؟ رواه الحاكم ما معنى رواه الحاكم؟
+
+177
+00:14:02,820 --> 00:14:07,040
+يعني أي حاكم ولا واحد؟الحاكم في المستدرك في
+
+178
+00:14:07,040 --> 00:14:10,540
+المستدرك على الصحيحين على شرط البخاري ومسلم
+
+179
+00:14:10,540 --> 00:14:14,500
+الأحاديث التي وردت في صحيح .. يعني في المستدرك
+
+180
+00:14:14,500 --> 00:14:19,700
+الحاكم لها يعني قريبة من أو هي نفسها شروط البخاري
+
+181
+00:14:19,700 --> 00:14:25,780
+ومسلم وتأخذ بها وهي صحيحة هذه يا أخوات يعني بعض
+
+182
+00:14:25,780 --> 00:14:30,780
+الآثار أو آيات قرآنية وحديث نبوية تبين فضل تلاوة
+
+183
+00:14:30,780 --> 00:14:34,580
+القرآن الكريمولكن القرآن الكريم كلام الله عز وجل
+
+184
+00:14:34,580 --> 00:14:39,660
+وينبغي علينا أن نتلوه ونحن نعظم كلام الله عز وجل
+
+185
+00:14:39,660 --> 00:14:45,760
+ولذلك لتلاوة القرآن أداب ما هي الأداب التي ينبغي
+
+186
+00:14:45,760 --> 00:14:50,580
+علينا أن نراعيها أثناء تلاوتنا للقرآن الكريم؟ في
+
+187
+00:14:50,580 --> 00:14:55,800
+أداب معينة الأدب الأول فضل ايه؟ صحيح
+
+188
+00:14:56,350 --> 00:14:59,910
+كلام الله عز وجل هو شعيرة من شعائر الله وهو صفة
+
+189
+00:14:59,910 --> 00:15:03,230
+قديمة من صفات الله سبحانه وتعالى لابد أن نعظمها
+
+190
+00:15:03,230 --> 00:15:08,090
+كما نعظم الله عز وجل ونعظم الكعبة ونعظم المقدسات
+
+191
+00:15:08,090 --> 00:15:12,330
+التي عندنا وهي يعني عظيم جدا لذلك الذي يتلو القرآن
+
+192
+00:15:12,330 --> 00:15:16,950
+الكريم لابد أن يعظمهميعظمه في التلاوة ويعظمه في
+
+193
+00:15:16,950 --> 00:15:20,510
+المعنى و كذلك يعظمه لو كانت عندنا مجموعة من
+
+194
+00:15:20,510 --> 00:15:25,010
+المصاحف أو كتب معينة محطوطة على الطاولة يعني ده
+
+195
+00:15:25,010 --> 00:15:29,370
+يجعل المصحف أول مصحف أول .. أول كتب من باب تعظيم
+
+196
+00:15:29,370 --> 00:15:33,660
+شعائر الله ربنا سبحانه وتعالى يقولوما يعظم شعائر
+
+197
+00:15:33,660 --> 00:15:38,520
+الله فإنها من تقوى القلوب إذا نعظم كلام الله لأنه
+
+198
+00:15:38,520 --> 00:15:42,000
+من شعائر الله عز وجل لأنه صفر من صفات الله سبحانه
+
+199
+00:15:42,000 --> 00:15:47,080
+وتعالى فنتقل القرآن ونحن نعظم القرآن الكريم ولنا
+
+200
+00:15:47,080 --> 00:15:51,280
+أجر عظيم على تعليمنا أو تعظيمنا للقرآن الكريم لو
+
+201
+00:15:51,280 --> 00:15:58,450
+واحد يا أخوات وجدت مثلاكلمة فيها لفظ الجلالة يعني
+
+202
+00:15:58,450 --> 00:16:04,350
+اسم أبو الله جزء من المصحف لفظ الجلالة مُلقى على
+
+203
+00:16:04,350 --> 00:16:09,050
+الأرض حتى نعظم لفظ الجلالة ونعظم كلام الله عز و جل
+
+204
+00:16:09,050 --> 00:16:14,500
+ماذا نفعل؟هل نجعلها مرمية على الأرض و لا نأخذها و
+
+205
+00:16:14,500 --> 00:16:19,740
+نرفعها و نضعها في مكان عظيم أو مكان مناسب أو إذا
+
+206
+00:16:19,740 --> 00:16:24,440
+كانت ورقة ممزقة نحرجها لا نلقيها لا في القمامة ولا
+
+207
+00:16:24,440 --> 00:16:29,660
+نرميها على الأرض لذلك ذلك من باب تعظيم لكلام الله
+
+208
+00:16:29,660 --> 00:16:35,590
+عز وجل و للشعائر الله سبحانه وتعالىطيب أدب أخر من
+
+209
+00:16:35,590 --> 00:16:39,090
+أداب تلاوة القرآن، تفضلي تدور القلب و التدبر فيها
+
+210
+00:16:39,090 --> 00:16:42,850
+لتلاوتي و فهم معانيه صحيح يعني لابد لمن أراد أن
+
+211
+00:16:42,850 --> 00:16:48,000
+يقرأ القرآن أن يتدبر معاني القرآن الكريموأن يعلم
+
+212
+00:16:48,000 --> 00:16:52,740
+بأن هو هو نفسه المخاطب بهذه الآية القرأنية إذا
+
+213
+00:16:52,740 --> 00:16:55,680
+الله سبحانه وتعالى قال له يا أيها الذين آمنوا
+
+214
+00:16:55,680 --> 00:16:59,620
+فليعلم أنه هو من الذين آمنوا وأن هذا الخطاب له
+
+215
+00:16:59,620 --> 00:17:04,530
+وإذا ذُكرت الجنة أو النار يتذكر بأن هذاالجنة
+
+216
+00:17:04,530 --> 00:17:08,010
+والنار ربنا سبحانه وتعالى جاء النار جعلها للكفار
+
+217
+00:17:08,010 --> 00:17:11,250
+والجنة جعلها للمؤمنين فيسأل الله الجنة ويستعيد
+
+218
+00:17:11,250 --> 00:17:17,070
+بالله من النار لذلك يبقى متعلق بالآية يتدبر ويتفكر
+
+219
+00:17:17,070 --> 00:17:21,970
+بها لا يكن قلبه غافلا لا يكن يقرأ القرآن وقلبه في
+
+220
+00:17:21,970 --> 00:17:26,570
+تفكير آخر الله سبحانه وتعالى يقول كتاب أنزلناه
+
+221
+00:17:26,570 --> 00:17:31,400
+إليك مبارك ليتدبر آياته وليتذكر أولي الألبابإذا
+
+222
+00:17:31,400 --> 00:17:36,400
+تدبر وتفكر وربنا عز وجل يقول أفلا يتدبرون القرآن
+
+223
+00:17:36,400 --> 00:17:42,300
+أم على قلوب أقفالها إذا الأدب الثاني حضور القلب
+
+224
+00:17:42,300 --> 00:17:46,960
+وتدبر فيه عند تلاوته وفهم معانيه من يدكر أدبا
+
+225
+00:17:46,960 --> 00:17:53,880
+ثالثا؟ تفضل أختكصحيح نقرأ القرآن مرتلا و الله
+
+226
+00:17:53,880 --> 00:17:57,960
+سبحانه و تعالى يقول ورتل القرآن ترتيلة مطلوب إننا
+
+227
+00:17:57,960 --> 00:18:03,260
+نرتل القرآن مجودا و من هنا نحن نتعلم أحكام التجويض
+
+228
+00:18:03,260 --> 00:18:07,340
+نتعلم أحكام التجويض حتى إيش أخوات نرتل القرآن
+
+229
+00:18:07,340 --> 00:18:11,060
+ترتيلة لا نتعلمهم من باب الترف بل نتعلمهم من باب
+
+230
+00:18:11,060 --> 00:18:15,360
+التطبيق يعني نتعلم أحكام التجويض و إذا رجعنا إلى
+
+231
+00:18:15,360 --> 00:18:20,350
+بيوتناينطبق ما اتعلمناه على كتاب الله عز وجل ومن
+
+232
+00:18:20,350 --> 00:18:24,190
+هنا هذا المساق .. مساق التلاوة والتجويض فيه جانبين
+
+233
+00:18:24,190 --> 00:18:29,110
+جانب عملي وجانب نظري نحن في هذه المحاضرة نتحدث عن
+
+234
+00:18:29,110 --> 00:18:33,970
+جانب النظري اتعلم أحكم التجويض و هناك محاضرة أخرى
+
+235
+00:18:34,220 --> 00:18:39,060
+زيادة أو رذيفة لهذه المحاضرة وهي الجانب التطبيقي
+
+236
+00:18:39,060 --> 00:18:42,820
+يعني نقرأ آيات من القرآن الكريم ونطبقها بإذ الله
+
+237
+00:18:42,820 --> 00:18:48,560
+عز وجل طيب أدب آخر يا أخوات فضليهأن يزين القارئ
+
+238
+00:18:48,560 --> 00:18:52,220
+قراءته ويحسن صوته بالقرآن صحيح يزينوا قراءته
+
+239
+00:18:52,220 --> 00:18:56,560
+ويحسنوا صوته بالقرآن الرسول عليه الصلاة والسلام
+
+240
+00:18:56,560 --> 00:19:01,420
+يقول لنا زينوا أصواتكم بالقرآن فإن الصوت الحسن
+
+241
+00:19:01,420 --> 00:19:06,120
+يزيد القرآن حسنه علينا أن نزين أصواتنا طبعا يا
+
+242
+00:19:06,120 --> 00:19:11,180
+أخوات معروف أن الواحد يعني عندما يستمت أو يستمع
+
+243
+00:19:11,180 --> 00:19:16,350
+إلى قارئ ذي صوت حسن إيش بيصير فيه؟يشعر بال ..
+
+244
+00:19:16,350 --> 00:19:20,830
+باللذة، بالسكينة، بالهدوء، بالتدبر، بالتفكر، بهذه
+
+245
+00:19:20,830 --> 00:19:25,070
+الأصوات النذيةوإذا سمع صوتا .. يعني .. يعني ..
+
+246
+00:19:25,070 --> 00:19:29,290
+يعني لو قرأ .. لو سمع واحد يقرأ القرآن كما يقرأ من
+
+247
+00:19:29,290 --> 00:19:34,030
+كتاب أو من جريدة لا يجد هذه المتعة أو هذه اللذة في
+
+248
+00:19:34,030 --> 00:19:39,050
+تلوته للقرآن لذلك حسنوا أصواتكم بالقرآن فإن الصوت
+
+249
+00:19:39,050 --> 00:19:43,490
+الحسن يزيد القرآن حسنا طبعا نجد يا أخوات أن بعض
+
+250
+00:19:43,490 --> 00:19:47,630
+الناس في صلاة الترويح في رمضان ينتقل من مسجد إلى
+
+251
+00:19:47,630 --> 00:19:53,050
+مسجد ينظر إلى صوت الإماموقراءة الإمام إن كانت
+
+252
+00:19:53,050 --> 00:19:56,970
+قراءة حسنة وصوته ندي ينتقل من المسجد إلى حارة
+
+253
+00:19:56,970 --> 00:20:01,290
+ثانية أو إلى مكان آخر لكي يستمع ويستمتع بصلاة
+
+254
+00:20:01,290 --> 00:20:05,130
+الترويخ لأنه يريد أن يصلّي عشرين ركعة أو يصلّي
+
+255
+00:20:05,130 --> 00:20:09,190
+مثلا تمام ركعات بصوت حسن فيجوز ينتقل من مكان إلى
+
+256
+00:20:09,190 --> 00:20:13,090
+مكان بس بشرط عدم إغلاق المسجد الذي هو فيه يعني إذا
+
+257
+00:20:13,090 --> 00:20:17,610
+كان والله المسجد الذي هو فيهأه ما بقولك، يعني إذا
+
+258
+00:20:17,610 --> 00:20:21,330
+كان يؤدي ذلك إلى أغلاق المسجد، لأ، يبقى في مسجده،
+
+259
+00:20:21,330 --> 00:20:25,790
+لكن إذا كان يريد أن يتدبر ويتفكر ويخشع ويذهب إلى
+
+260
+00:20:25,790 --> 00:20:29,290
+الإمام أو المسجد اللي فيه إمام منحسن، يعني يجوزه
+
+261
+00:20:29,290 --> 00:20:34,170
+ذلك ولا شيء عليا، أدب آخر يا أخوات، اتفضل أخت يقول
+
+262
+00:20:34,170 --> 00:20:36,330
+ان قارة على تقارة كاملة في البداية والتانية
+
+263
+00:20:36,330 --> 00:20:40,110
+والمكان، لقال اللهم تعالى أنه لقرآن كريم في كتابه
+
+264
+00:20:41,760 --> 00:20:45,780
+لا يمسه إلا المظهر صحيح يا أخوات لابد لمن أراد أن
+
+265
+00:20:45,780 --> 00:20:50,260
+يقرأ القرآن أن يكون على طهارة كاملة طهارة البدن
+
+266
+00:20:50,260 --> 00:20:53,660
+والثو والمكان ما معنى طهارة البدن يا أخوات؟
+
+267
+00:20:56,090 --> 00:21:01,170
+يعني طهارة البدن من الجنابة من الحيض من النفاس
+
+268
+00:21:01,170 --> 00:21:06,810
+يكون ليس عليه نجاسات معينة مثلا يكونوا على وضوء
+
+269
+00:21:06,810 --> 00:21:11,310
+هذه الطهارة لأن القرآن لا يمسه إلى المطهرون طهارة
+
+270
+00:21:11,310 --> 00:21:15,750
+البدن و طهارة الثوب و طهارة المكان طهارة الثوب إيه
+
+271
+00:21:15,750 --> 00:21:21,230
+شعاران طهارة الثوب؟ألا يكون على ملابسه نجاسة مطهرة
+
+272
+00:21:21,230 --> 00:21:24,830
+المكان أن يكون المكان الذي يقرأ القرآن فيه مكان
+
+273
+00:21:24,830 --> 00:21:29,710
+يعني نظيف وطاهر لا يقرأ القرآن في مكان نجاسات في
+
+274
+00:21:29,710 --> 00:21:33,670
+مكان يعني في .. في مكان يعني لأ غير مناسب يقرأ
+
+275
+00:21:33,670 --> 00:21:38,030
+القرآن ويتدبر القرآن حتى يحصل الأجر العظيم الذي
+
+276
+00:21:38,030 --> 00:21:42,630
+جعله الله عز وجل لمن يقرأ القرآن من يأتي بأدب آخر
+
+277
+00:21:42,630 --> 00:21:47,690
+فضل أخت أتت بأدب القرآن و خلجت و لا يعرف القرآن؟
+
+278
+00:21:49,620 --> 00:21:53,440
+أحسنتي تبقى نتأذب عند تلاوة القرآن الكريم نعرف
+
+279
+00:21:53,440 --> 00:21:58,260
+أننا نقرأ كلام الله نقف بين يراي الله عز وجل لا
+
+280
+00:21:58,260 --> 00:22:03,140
+نضحك ولا نعبث ولا ننظر إلى ما يلهيلا ننظر إلى
+
+281
+00:22:03,140 --> 00:22:08,700
+التلفزيون مثلا أو إلى لعبة كرة قدم أو إلى الشارع
+
+282
+00:22:08,700 --> 00:22:13,720
+فيه هناك مشاكل و أنا أتل القرآن لأ لاود أن يعني
+
+283
+00:22:13,720 --> 00:22:17,800
+أتدبر الآيات و أتأدب عند تلاوتي للقرآن الكريم فلا
+
+284
+00:22:17,800 --> 00:22:24,000
+أفعل شيء يعني يلهي عن القرآن الكريم لأضحكولا ألعب
+
+285
+00:22:24,000 --> 00:22:28,840
+أو أعبث ولا أنظر إلى ما يلهي ومن الأداب والأخلاق
+
+286
+00:22:28,840 --> 00:22:32,440
+الحسنة أن أكون مستقبلا للقبلة ده الشريفة طبعا هذه
+
+287
+00:22:32,440 --> 00:22:36,680
+أخوات أداب يعني لو واحد مثلا كان بسوق سيارة وقعد
+
+288
+00:22:36,680 --> 00:22:40,160
+بيقرأ القرآن من باب أنه يستغل وقته في قراءة القرآن
+
+289
+00:22:40,160 --> 00:22:44,240
+جائز لو واحد مثلا كان رايع على الجامع عن المسجد
+
+290
+00:22:44,240 --> 00:22:48,120
+ويريد في الطريق أن يتذكر الأيات القرانية حسن يقيتل
+
+291
+00:22:48,120 --> 00:22:54,000
+القرآن لو كان نايمأو يعني مضجع و يريد أن يذكر
+
+292
+00:22:54,000 --> 00:22:57,980
+الآيات أو يقرأ .. يجوز لكن من باب الأدب إذا أراد
+
+293
+00:22:57,980 --> 00:23:02,540
+أن يعني يحصل أجر و الثواب العظيم أن يستقبل القبلة
+
+294
+00:23:02,540 --> 00:23:05,240
+الشريفة و يكون طاهر البدن و الثوب المكان و يعظم
+
+295
+00:23:05,240 --> 00:23:09,840
+كلام الله عز وجل و يعني .. و يقرأ القرآن بصوت حسن
+
+296
+00:23:09,840 --> 00:23:16,060
+و هكذا طيب .. أدب آخر يا أخوات أن يستشعر بأنه
+
+297
+00:23:16,060 --> 00:23:20,460
+مخاطب بكل آية يقرا صحيحعبد الله ابن مسعود ماذا
+
+298
+00:23:20,460 --> 00:23:23,620
+يقول؟ يقول عبد الله ابن مسعود رضي الله عنه إذا
+
+299
+00:23:23,620 --> 00:23:28,820
+سمعت الله يقول يا أيها الذين آمنوا فرعها سمعك فإما
+
+300
+00:23:28,820 --> 00:23:34,440
+فرعها سمعك فإنه خير يأمرك الله به أو شر ينهاك الله
+
+301
+00:23:34,440 --> 00:23:38,600
+عنهم إما أن يكون خير ربنا بيأمرك به أو شر ربنا
+
+302
+00:23:38,600 --> 00:23:42,280
+ينهان عنهم لذلك دائما يا أخوات إذا سمعنا يا أيها
+
+303
+00:23:42,280 --> 00:23:47,500
+الذين آمنوا من الذين آمنوا؟نحن يا أيها الذين أمنوا
+
+304
+00:23:47,500 --> 00:23:51,160
+يعني انتبه زي ما واحد ينادي عليك يا فلان انتبه،
+
+305
+00:23:51,160 --> 00:23:55,540
+ايش اللي بعدها؟ بعدها إما أن يأمرنا بخير يأمرنا
+
+306
+00:23:55,540 --> 00:23:59,580
+الله به أو شر ينهان الله عنه، يأمرنا بخير يا أيها
+
+307
+00:23:59,580 --> 00:24:03,980
+الذين أمنوا أقيموا الصلاة، آتوا الذكاء، يعني
+
+308
+00:24:03,980 --> 00:24:07,340
+انفلوا كفافة و اثقالة وغير ذلك من الآيات اللي فيها
+
+309
+00:24:07,340 --> 00:24:11,860
+أوامر، يبقى الأوامر إلناو أو شر لا تقربوا الصلاة و
+
+310
+00:24:11,860 --> 00:24:16,520
+أنتم سكارة لا تفعلوا كذا و كذا فهي ينهانا عن شر و
+
+311
+00:24:16,520 --> 00:24:19,760
+الله عز و جل العظيم و لا يأمرنا إلا بخير و لا
+
+312
+00:24:19,760 --> 00:24:24,080
+ينهانا إلا .. إلا عن شر و نحن نسمع و نطيع لأمر
+
+313
+00:24:24,080 --> 00:24:26,800
+الله سبحانه و تعالى و الله عز و جل يقول لنا يا
+
+314
+00:24:26,800 --> 00:24:31,180
+أيها الذين أمنوا أطيعوا الله و أطيعوا الرسول نطيع
+
+315
+00:24:31,180 --> 00:24:34,500
+الله بأوامره و نطيع الرسول لأن الرسول عليه الصلاة
+
+316
+00:24:34,500 --> 00:24:39,700
+و السلام جاء بالسنةوالسنة هي المصدر الثاني من
+
+317
+00:24:39,700 --> 00:24:44,520
+مصادر التشريع الإسلامي يعني الرسول عليه الصلاة
+
+318
+00:24:44,520 --> 00:24:49,540
+والسلام يقول لنا ألا إني أوتيت القرآن ومثله معه
+
+319
+00:24:49,540 --> 00:24:53,860
+يعني في عندنا قرآن وفي مثل القرآن معه اللي هي
+
+320
+00:24:53,860 --> 00:24:57,260
+السنة النبوية والسنة النبوية ربنا سبحانه وتعالى
+
+321
+00:24:57,260 --> 00:25:01,780
+يقول لنا لقد كان لكم في رسول اللهأسوة حسنة ويقول
+
+322
+00:25:01,780 --> 00:25:06,160
+كذلك وما آتاكم الرسول فاخدوه وما نهاكم عنه فانتهوا
+
+323
+00:25:06,160 --> 00:25:11,740
+إذا الرسول بالنسبة لنا هو المعلم والأستاذ والمربي
+
+324
+00:25:11,740 --> 00:25:16,160
+ورسول الله صلى الله عليه وسلم معلمنا بيبين وبيوضح
+
+325
+00:25:16,160 --> 00:25:19,920
+وبيشرح ما جاء في القرآن الكريم فالسنة هي الموضحة
+
+326
+00:25:19,920 --> 00:25:23,380
+والشارحة والمبينة والمفصلة لما ورد في القرآن
+
+327
+00:25:23,380 --> 00:25:27,200
+الكريم طيب أخوات أدب أخر من أداب تلاوتنا للقرآن
+
+328
+00:25:27,200 --> 00:25:34,530
+الكريمفضل ايه؟ اذا
+
+329
+00:25:34,530 --> 00:25:39,230
+كان بحضرة من يقرأ طبعا يقرأ اما امامه رجل يقرأ
+
+330
+00:25:39,230 --> 00:25:46,240
+وشيخأو الإمام أو حتى في مذيع أو حتى في تلفزيون أو
+
+331
+00:25:46,240 --> 00:25:50,040
+في مسجل أو في جوال أو مقرفون المسجد و هي في البيت
+
+332
+00:25:50,040 --> 00:25:54,240
+مثلا عليها أن تستبع ربنا سبحانه وتعالى يقول وإذا
+
+333
+00:25:54,240 --> 00:25:59,500
+قرئ القرآن فاستمعوا له وانصتوا لعلكم ترحمونه ربنا
+
+334
+00:25:59,500 --> 00:26:03,620
+سبحانه تعالى يرحم الذين يستمعون للقرآن و يخشعون
+
+335
+00:26:03,620 --> 00:26:07,980
+بتلاوتهم للقرآن الكريم أدب آخر يا أخوات فضلي
+
+336
+00:26:12,520 --> 00:26:18,600
+صحيح يستحبوا لمستمع القرآن أو لقارئ القرآن أن يبكي
+
+337
+00:26:18,600 --> 00:26:23,820
+أو يتباكى لأن القرآن نزل بحزن فيه ذكر الجنة وفيه
+
+338
+00:26:23,820 --> 00:26:28,480
+ذكر النار يعني إذا مرت عليه آيات الجنة بكى اشتياقا
+
+339
+00:26:28,480 --> 00:26:33,160
+للجنة وشوقا لرحمة الله عز وجل وإذا مرت عليه آيات
+
+340
+00:26:33,160 --> 00:26:37,840
+فيها ذكر النار بكى خوفا من النار فالمرء لابد أن
+
+341
+00:26:37,840 --> 00:26:43,670
+يكون بين الخوف و بين الرجالأدب آخر يا أخوان ..
+
+342
+00:26:43,670 --> 00:26:47,670
+فضليه .. ألا يخلط القارئ بين القراءات والروايات
+
+343
+00:26:47,670 --> 00:26:52,230
+والطرق وعليه أن يتعلم قراءة معينة متصلة برسول الله
+
+344
+00:26:52,230 --> 00:26:55,370
+صلى الله عليه وسلم صحيح ألا يخلط القارئ بين
+
+345
+00:26:55,370 --> 00:26:59,610
+القراءات والروايات والطرق طبعا في عندنا قراءات ..
+
+346
+00:26:59,610 --> 00:27:05,290
+أه في عندنا قراءات يعني في ابن مجاهد ألف كتاب
+
+347
+00:27:05,290 --> 00:27:08,290
+الحجة في القراءات السبعة أو السبعة .. السبعة في
+
+348
+00:27:08,290 --> 00:27:13,440
+القراءاتو كذلك في هناك تحفظ رأى البشر في القراءات
+
+349
+00:27:13,440 --> 00:27:16,340
+الأربعة عشر في عندنا النشر في القراءات العشر إذا
+
+350
+00:27:16,340 --> 00:27:21,680
+في عندنا سبع قراءات متواترة وزيد عليها كمان تلت
+
+351
+00:27:21,680 --> 00:27:25,140
+قراءات متواترة هناخدها إن شاء الله صار عندنا عشر
+
+352
+00:27:25,140 --> 00:27:28,760
+قراءات متواترة والقراءات المتواترة يا أخوات كلها
+
+353
+00:27:28,760 --> 00:27:33,620
+قرآن يصح لنا أن نقرأ بها ونتعبد الله بها لا نفرض
+
+354
+00:27:33,620 --> 00:27:37,120
+القراءة على قراءة لا نقول والله قراءة حفظ عن عاصم
+
+355
+00:27:37,120 --> 00:27:41,080
+أفضل من قراءة ورشع النافعفنحن نقرأ بهذه القراءة
+
+356
+00:27:41,080 --> 00:27:45,620
+ونصلّي بها ونتمتع ونستمتع بقراءة القرآن بقراءة حفص
+
+357
+00:27:45,620 --> 00:27:50,620
+عن عاصم وغيرنا يقرأ بقراءة ورشع النافع فنحن نقرهم
+
+358
+00:27:50,620 --> 00:27:55,440
+وهم يقروننا وكله قرآن و هناك أربع قراءات ثانية
+
+359
+00:27:55,440 --> 00:27:59,180
+صحيحة يعني ليست متواترة ولم تنطبق عليها شروط
+
+360
+00:27:59,180 --> 00:28:03,960
+التواتر لكنها صحيحة تُأخذ في التفسير زي مثلا وكان
+
+361
+00:28:03,960 --> 00:28:10,020
+وراءهم ملك يأخذ كل سفينة صالحة غصبةيعني كلمة صالحة
+
+362
+00:28:10,020 --> 00:28:15,960
+مش موجودة عندنا تسمى تفسيريا أو وكان أمامهم مش
+
+363
+00:28:15,960 --> 00:28:20,800
+وراءهم وكان أمامهم ملكهم فتفسر الآية إنه لم يكن
+
+364
+00:28:20,800 --> 00:28:24,160
+الملك الظالم الذي كان يأخذ السفينة وراءهم وإنما
+
+365
+00:28:24,160 --> 00:28:27,760
+كان أمامهم لأن السفينة تسير إلى الأمام ولا ترجع
+
+366
+00:28:27,760 --> 00:28:31,950
+إلى الوراءتسيروا إلى الأمام فالأيات بتفسر بعضها
+
+367
+00:28:31,950 --> 00:28:37,150
+بعض فكان أمامهم في الأمام و بعدين الملك ياخد كل
+
+368
+00:28:37,150 --> 00:28:42,630
+سفينة على جنب ولا كل سفينة صالحة كل سفينة صالحة
+
+369
+00:28:42,630 --> 00:28:48,190
+فالخضر عندما خلق السفينة لمصلحت أهل السفينة ولا
+
+370
+00:28:48,190 --> 00:28:53,880
+ليست لمصلحتهملمصلحتهم لأنه لو لم يخرقها لأخذها
+
+371
+00:28:53,880 --> 00:28:58,940
+الملك لكنه لما خرقها رفضها الملك فأصلحوها بعد أن
+
+372
+00:28:58,940 --> 00:29:03,260
+رجعوا إلى بيوتهم لذلك لأنها كانت مساكين فيعني
+
+373
+00:29:03,260 --> 00:29:08,360
+خرقها و ذلك لأنه أوتيها من علم الله عز وجل اللدن
+
+374
+00:29:08,360 --> 00:29:12,640
+طيب يعني القراءات لا يخلط بين القراءات يعني ما
+
+375
+00:29:12,640 --> 00:29:17,570
+بنفعل الإمام مثلا أن يقرأ أثناء الصلاة الواحدةيخلط
+
+376
+00:29:17,570 --> 00:29:20,970
+ما بين قراءة ورش عن نافع، حفص عن عاصم، الدور عن
+
+377
+00:29:20,970 --> 00:29:24,490
+أبي عمر، مثلا كذا و كذا من القراءات، لا يصح أن
+
+378
+00:29:24,490 --> 00:29:28,250
+يقرأ .. لابد أن يقرأ قراءة واحدة، وإذا أراد أن
+
+379
+00:29:28,250 --> 00:29:35,090
+يغير .. يغير مثلا .. يقرأ أمام الناس بقراءة ورش عن
+
+380
+00:29:35,090 --> 00:29:39,600
+نافع، نحن أهل الشام نقرأ بقراءة إيش؟حفص عن عاصر
+
+381
+00:29:39,600 --> 00:29:44,740
+يعني مثلا مالك يوم الدين هكذا قرأت حفص عن عاصر في
+
+382
+00:29:44,740 --> 00:29:49,780
+قراءة ورشع النافع مالك يوم الدين لو جاء إمام وقرأ
+
+383
+00:29:49,780 --> 00:29:56,040
+وغير بعض الألفاظ لأنه القراءة بتتغير بعض الإمالة و
+
+384
+00:29:56,040 --> 00:30:00,680
+التفخير و الترقيق وغيرها لو قال الإمام مالك يوم
+
+385
+00:30:00,680 --> 00:30:03,600
+الدين عندنا دون أن يعلم الناس أن انا أريد أن أقرأ
+
+386
+00:30:03,600 --> 00:30:09,080
+بقراءة ورشع النافعيظنوا الناس بأن القارئ قد أخطأ
+
+387
+00:30:09,080 --> 00:30:13,680
+فيردونه فيقول إن والله مالك يوم الدين مش عارف
+
+388
+00:30:13,680 --> 00:30:16,840
+القراءة؟ مالك يوم الدين هي .. وليس ملك مع أنه
+
+389
+00:30:16,840 --> 00:30:21,080
+قراءات مالكي وملك كلا هما إيه قراءات يعني صحيحة
+
+390
+00:30:21,080 --> 00:30:24,320
+فلوضع أن يقرأ إلا إذا كان في مقام التعليم يعني في
+
+391
+00:30:24,320 --> 00:30:30,460
+عندنا مثلا درسنعلم طلاب أوجه القراءات هي جزء لنا
+
+392
+00:30:30,460 --> 00:30:35,200
+أن نستعرض أوجه الاختلاف في القراءات نقول مثلا مالك
+
+393
+00:30:35,200 --> 00:30:43,300
+يوم الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+394
+00:30:43,300 --> 00:30:44,900
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+395
+00:30:44,900 --> 00:30:45,800
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+396
+00:30:45,800 --> 00:30:48,000
+الدين، ملك يوم الدين، ملك يوم الدين، ملك يوم
+
+397
+00:30:48,000 --> 00:30:55,340
+الدين، ملك يوم الدين،ملكة ملكي قرأتين متواترات
+
+398
+00:30:55,340 --> 00:31:01,660
+وقرأتين شذات غير متواترات ممكن يعني لا يوخى بيها
+
+399
+00:31:01,660 --> 00:31:07,840
+أخر أدب من أداب التلاوة أشهر بنات فضل أختك على
+
+400
+00:31:07,840 --> 00:31:11,420
+المرد أن يرجوا بالتلاوات وجه دراسة عالم وما عندهم
+
+401
+00:31:11,420 --> 00:31:16,400
+الدراجة والتوافرة بتاعة النبياه والصمعةصحيح انت
+
+402
+00:31:16,400 --> 00:31:20,500
+مهم جدا لابد ان نقرأ القرآن نبتدي من وراق قراءتنا
+
+403
+00:31:20,500 --> 00:31:23,670
+القرآن ايش يا أخوات؟واجه الله سبحانه وتعالى لا
+
+404
+00:31:23,670 --> 00:31:29,370
+نريده مالا ولا نريده سمعة ولا رياء لأن الله سبحانه
+
+405
+00:31:29,370 --> 00:31:33,670
+وتعالى لا يقبل أو لا يقبل أن يشرك بيه أحد ولابد أن
+
+406
+00:31:33,670 --> 00:31:36,930
+نبتغي من وراء قراءتنا واجه الله عز وجل فمن قرأ
+
+407
+00:31:36,930 --> 00:31:40,470
+القرآن حتى يأخذ الأجر في نهاية القراءة هذا لا يحصل
+
+408
+00:31:40,470 --> 00:31:44,630
+الأجر من عند الله عز وجل لأنه أخذ الأجر من الناس
+
+409
+00:31:44,630 --> 00:31:48,270
+فالله سبحانه وتعالى أغنى الأغنياء عن الشرك لذلك
+
+410
+00:31:48,270 --> 00:31:57,170
+نبتغي من الله الأجر والثوابعلى هذه التلوة ننتقل
+
+411
+00:31:57,170 --> 00:32:02,730
+يا أخوات إلى نقطة أخرى وهي نشأة علم التجويد أنهينا
+
+412
+00:32:02,730 --> 00:32:07,330
+الآنأداب تلاوة القرآن الكريم وقبلها فضل تلاوة
+
+413
+00:32:07,330 --> 00:32:11,810
+القرآن الكريم لو .. لو أردنا أن نأتي بسؤال ممكن
+
+414
+00:32:11,810 --> 00:32:17,010
+نقول عرفي القرآن الكريم ثم بيني دليلا يبينوا فضل
+
+415
+00:32:17,010 --> 00:32:21,930
+تلاوة القرآن الكريم ثم أذكري خمسا من أدابي تلاوة
+
+416
+00:32:21,930 --> 00:32:26,270
+القرآن الكريم بهذا الشكل سؤال متكامل حتى نحصل
+
+417
+00:32:26,270 --> 00:32:31,970
+الدرجات المناسبة النقطة الثانية يا أخوات متى أنشأ
+
+418
+00:32:31,970 --> 00:32:38,350
+علم التجبيد؟أه .. إيه شميني على .. فضلي .. إذا
+
+419
+00:32:38,350 --> 00:32:41,070
+أنشأ علم التجويض منذ اللحظة التي نزل فيها القرآن
+
+420
+00:32:41,070 --> 00:32:45,350
+التريم على رسول صلى الله عليه وسلم .. أحسنته ..
+
+421
+00:32:45,350 --> 00:32:50,970
+إذا يا أخوات حقيقة أول علم من علوم القرآن كان علم
+
+422
+00:32:50,970 --> 00:32:55,870
+.. علم التجويض لأنه نزل منذ أو كان منذ اللحظة
+
+423
+00:32:55,870 --> 00:32:59,370
+الأولى الذي نزل فيها القرآن على الرسول عليه الصلاة
+
+424
+00:32:59,370 --> 00:33:02,950
+والسلامكان جبليلو يلقي النبي عليه الصلاة والسلام
+
+425
+00:33:02,950 --> 00:33:07,070
+القرآن مجودا والرسول عليه الصلاة والسلام يعلمه
+
+426
+00:33:07,070 --> 00:33:10,890
+للصحابة مجودا والصحابة يتناقلونه بينهم ويعلمونه
+
+427
+00:33:10,890 --> 00:33:16,150
+للتابعين أيضا مجودا فكان التجويض العملي أول علم من
+
+428
+00:33:16,150 --> 00:33:21,610
+علوم القرآن موجود لأن نزوله كان منذ اللحظة الأولى
+
+429
+00:33:21,610 --> 00:33:25,990
+لنزول القرآن الكريم ويعادوا علم التجويض أول علم من
+
+430
+00:33:25,990 --> 00:33:30,910
+علوم القرآن نشأةطيب لو سألنا سؤال أيهما كان قبل
+
+431
+00:33:30,910 --> 00:33:35,170
+علم التجويض النظري ولا علم التجويض العملي؟ احنا
+
+432
+00:33:35,170 --> 00:33:40,590
+ممكن نقول عندما نتعلم نحن أول شي نتعلم نظري بعدين
+
+433
+00:33:40,590 --> 00:33:45,210
+عملي لكن من حيث النشأة أيهما كان قبل العملي ولا
+
+434
+00:33:45,210 --> 00:33:48,770
+النظري؟ فضل نقطة التجويض العملي نشأ قبل التجويض
+
+435
+00:33:48,770 --> 00:33:52,610
+النظري لأن القرآن نزل مجودا من جبليل على قلب رسول
+
+436
+00:33:52,610 --> 00:33:56,700
+اللهوقام الرسول بعد ذلك بتعامل بالصحابة المجاورة
+
+437
+00:33:56,700 --> 00:34:00,480
+ممتاز، إذا التجويض العملي كان قبل التجويض النظري
+
+438
+00:34:00,480 --> 00:34:06,060
+ثم بعد مائة سنة أخذ العلماء يستلبطوا من التجويض
+
+439
+00:34:06,060 --> 00:34:11,080
+العملي يعني أحكام معينةحتى وصل إلى العلم الذي نحن
+
+440
+00:34:11,080 --> 00:34:15,120
+فيه وهو علم التجويض النظري إذا التجويض العملي كان
+
+441
+00:34:15,120 --> 00:34:18,120
+مقدم على تجويض النظري الرسول عليه الصلاة والسلام
+
+442
+00:34:18,120 --> 00:34:22,540
+كان يعلمه للصحابة عمليا لأنه كان يستلقاه من جبريل
+
+443
+00:34:22,540 --> 00:34:27,060
+مجودا يعلمه للصحابة مجودا الصحابة كان يعلمونه
+
+444
+00:34:27,060 --> 00:34:31,160
+للتابعين مجودا والتابعون يعلمونه لأتباع التابعين
+
+445
+00:34:31,160 --> 00:34:35,760
+وهكذا مجودا إلى أن وصل القرآن فالقرآن يُأخذه
+
+446
+00:34:35,760 --> 00:34:45,610
+بمشافة وبالتلقىطيب لكن متى بدأ تدوين علم التجويض؟
+
+447
+00:34:45,610 --> 00:34:51,390
+اه تفضل اختكفي القرن الثاني للهجرة بدأ تدوين علم
+
+448
+00:34:51,390 --> 00:34:55,770
+التجويض حيث بدأ عصر التدوين يعني في عهد عمرو بن
+
+449
+00:34:55,770 --> 00:35:00,470
+عبد العزيز بدأ يدون السنة وجمع الأحاديث لأن
+
+450
+00:35:00,470 --> 00:35:05,050
+الصحابة رضي الله عنهم أصبحوا يعني ممكن يفقدوا
+
+451
+00:35:05,050 --> 00:35:09,490
+ويموتوا الواحد والآخر فكان الصحابة العلماء بحاجة
+
+452
+00:35:09,490 --> 00:35:12,250
+إلى أن يجمعوا أحاديث النبي عليه الصلاة والسلام
+
+453
+00:35:12,250 --> 00:35:16,730
+ويجمعوا العلوم وكان من ضمن العلوم التي جمعتهو
+
+454
+00:35:16,730 --> 00:35:22,230
+بداية تدوين لعلم التجويض ولكن يعني علم التجويض بعض
+
+455
+00:35:22,230 --> 00:35:25,970
+العلماء بدأ في علوم معينة يعني علم التجويض يعني
+
+456
+00:35:25,970 --> 00:35:30,970
+يتحدث عن أو يستنبط أحكام التجويض من قراءة الرسول
+
+457
+00:35:30,970 --> 00:35:34,710
+بعلم معين يعني بعضهم استنبط أحكام اللون الساكنة
+
+458
+00:35:34,710 --> 00:35:38,230
+والتنوين بعضهم استنبط مخارج الحروف بعضهم استنبط
+
+459
+00:35:38,230 --> 00:35:42,360
+مثلا أحكام المدون بعضهم التفخيم والترقيخ وهكذاو ..
+
+460
+00:35:42,360 --> 00:35:47,820
+و لذلك اختلف من هو أول من صنع في علوم التجويض
+
+461
+00:35:47,820 --> 00:35:52,540
+والصحيح أنه كل .. كل واحد بدل مجهودا كان من أول من
+
+462
+00:35:52,540 --> 00:35:55,800
+صنع في علم التجويض هنا أول من دوّن في علم التجويض
+
+463
+00:35:55,800 --> 00:36:01,340
+هو قيل أنه أبو الأسود الدوانيوقيل أنه الخليل ابن
+
+464
+00:36:01,340 --> 00:36:05,980
+أحمد الفراهيدي وقيل أبو عبيد القاسي ابن سلام وقيل
+
+465
+00:36:05,980 --> 00:36:12,980
+غيرهم لكن الصواب ممكن نقول كلهم لهم إيش؟ لهم يعني
+
+466
+00:36:12,980 --> 00:36:17,200
+مكانة في عملية التدوين أو التجويب لأنه كل واحد
+
+467
+00:36:17,200 --> 00:36:22,720
+يعني صنف واجتهد و أظهر علما في علم التجويب لكن بعد
+
+468
+00:36:22,720 --> 00:36:26,660
+ذلك أخذ العلماء يجمعوا هذه العلوم يعني أول من بدأ
+
+469
+00:36:26,660 --> 00:36:31,720
+يفكر في تدوينعلم التجويض ويستنبط اللي هو أبو
+
+470
+00:36:31,720 --> 00:36:36,960
+الأسود الدولي وغيرهم بعد ذلك بعد مائة سنة ولا متين
+
+471
+00:36:36,960 --> 00:36:40,960
+سنة أصبح العلماء يعني يجمعوا هذه العلوم في كتب
+
+472
+00:36:40,960 --> 00:36:45,880
+مستقلة منهم مكي ابن أبي طالب الذي توفي سنة أربعمية
+
+473
+00:36:45,880 --> 00:36:51,420
+و سبعة و تلاتين من الهجرة ألف كتاب اسمه الرعاية
+
+474
+00:36:51,420 --> 00:36:56,240
+لتجويض القراءة وتحقيق لفظ التلاوةكتاب جمع فيه ما
+
+475
+00:36:56,240 --> 00:37:01,540
+استنبطه العلماء في كتاب واحد ثم أبو عمر الداني
+
+476
+00:37:01,540 --> 00:37:07,940
+الذي توفي سنة 444 من الهجرة ألف كتاب اسمه التحديد
+
+477
+00:37:07,940 --> 00:37:12,440
+في علم الإتقان والتجويد كذلك ابن الجزري محمد ابن
+
+478
+00:37:12,440 --> 00:37:18,760
+الجزري الذي توفي سنة 833 يعني بعد 800 سنةألف كتاب
+
+479
+00:37:18,760 --> 00:37:21,420
+اسمه التمهيد في علم التجويض و كذلك ابن الله
+
+480
+00:37:21,420 --> 00:37:26,200
+الجزرية اللي هو جمع علم التجويض بقصيدة من باب
+
+481
+00:37:26,200 --> 00:37:30,360
+التسهيل في علم التجويض وهي موجودة الآن كذلك الشيخ
+
+482
+00:37:30,360 --> 00:37:34,380
+سليمان الجمزوري المولود سنة ألف ومية و تلاتة و
+
+483
+00:37:34,380 --> 00:37:38,460
+تسعين من الهجرة نظم شعرا وسماه تحفة تحفة الأطفال
+
+484
+00:37:38,830 --> 00:37:42,970
+تحفظ الأطفال يعني نظمة شعرا يجمع علم التجويز في
+
+485
+00:37:42,970 --> 00:37:47,270
+قصيدة سهلة كان يحفظها مين؟ الأطفال لأنه كان
+
+486
+00:37:47,270 --> 00:37:51,490
+الأطفال هم الذين يتعلمون في الكتاتيب ويحفظوا
+
+487
+00:37:51,490 --> 00:37:55,770
+القرآن كمين فكانوا يحفظونهم والذي يحفظ المتون ينال
+
+488
+00:37:55,770 --> 00:38:00,980
+إيش؟ ينال الفلوننكتفي نحن بهذا القدر حتى ان شاء
+
+489
+00:38:00,980 --> 00:38:04,160
+الله نبدأ في المحاضرة القادمة التي هي بعنوان
+
+490
+00:38:04,160 --> 00:38:08,660
+الأحرو السبعة في القرآن الكريم نحن ندعوكم إلى شراء
+
+491
+00:38:08,660 --> 00:38:12,660
+هذا الكتاب اسمه المغني في علم التجويض هذا الكتاب
+
+492
+00:38:12,660 --> 00:38:16,140
+معكم هو هيكون المقرر بإذن الله عز وجل بالإضافة
+
+493
+00:38:16,140 --> 00:38:19,060
+لهذه المادة طبعا المادة موجودة في صفحة صفحة
+
+494
+00:38:19,060 --> 00:38:23,600
+المدرسين صفحة أنا بمكان كل طالبة أن تفتح على صفحة
+
+495
+00:38:23,600 --> 00:38:28,310
+المدرس زهد أبو نعمةو تدخل على الموقع وتأخذ المادة
+
+496
+00:38:28,310 --> 00:38:32,730
+نفسها وهي وجميع المواد وهناك أسئلة كثيرة وفي فايدة
+
+497
+00:38:32,730 --> 00:38:35,530
+عظيمة ان شاء الله سوف تجدونها في الموقع بارك الله
+
+498
+00:38:35,530 --> 00:38:39,390
+فيكم والسلام عليكم ابقوا مكانكم يا أخوات
+
+499
+00:38:44,360 --> 00:38:49,560
+يا أخوتي احنا عند طالبات و بناخد حضور و غياب اليوم
+
+500
+00:38:49,560 --> 00:38:52,920
+مش راح ناخد حضور و غياب لأن أول محاضرة لكن في
+
+501
+00:38:52,920 --> 00:38:55,640
+المحاضرة القادمة السبوع القادم هنبدأ في حضور و
+
+502
+00:38:55,640 --> 00:39:00,670
+غياب الحضور و الغياب عليه عشر درجاتعشان الدرجات هو
+
+503
+00:39:00,670 --> 00:39:04,850
+و ال quizات هنعطيكم في خلال الفصل quizين يعني كل
+
+504
+00:39:04,850 --> 00:39:09,950
+تلت أسابيع quiz و quiz قبل الامتحان النصفي و quiz
+
+505
+00:39:09,950 --> 00:39:13,030
+بعد الامتحان النصفي على أساس نكون .. يعني ندرس
+
+506
+00:39:13,030 --> 00:39:16,690
+للامتحان النصفي طبعا الامتحان عليه درجتين ندرس
+
+507
+00:39:16,690 --> 00:39:24,500
+لدرجتين سهل جدالكن ايه؟ عساس ان لو قدمنا الامتحان
+
+508
+00:39:24,500 --> 00:39:28,040
+النصفي عليه عشانين درجة نكون قرينا المادة لإن بعض
+
+509
+00:39:28,040 --> 00:39:31,940
+الأخوات لا يقرؤون إلا إيش؟ إلا للامتحان فنحن نريد
+
+510
+00:39:31,940 --> 00:39:35,840
+أن نقرأ قراءتين قراءة قبل الامتحان باسبوعين يعني
+
+511
+00:39:35,840 --> 00:39:39,300
+قبل ما تبدأ الامتحانات نكون احنا خلصنا جزء من
+
+512
+00:39:39,300 --> 00:39:43,480
+المقرر قررناحتى إذا أخدنا الامتحان النصفي نكون
+
+513
+00:39:43,480 --> 00:39:46,020
+جارينا عدد كبير كذلك الامتحان النهائي .. قبل ما
+
+514
+00:39:46,020 --> 00:39:49,460
+نخد الامتحان نهائي ناخد كمان quiz حتى نأتي لامتحان
+
+515
+00:39:49,460 --> 00:39:53,400
+النهائي و نكون ايش يا أخوات .. مخدين النصف الثاني
+
+516
+00:39:53,400 --> 00:39:57,020
+و نفهم القرآن لإن احنا نفتخر فيكم و نريد منكم
+
+517
+00:39:57,020 --> 00:39:59,560
+جميعا أن تحصلوا أعلى درجات و برك الله فيكم و
+
+518
+00:39:59,560 --> 00:40:00,060
+السلام عليكم
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M.srt
new file mode 100644
index 0000000000000000000000000000000000000000..a503ba7b815d9b1fea5c5206aa6e531554cd61be
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M.srt
@@ -0,0 +1,1479 @@
+1
+00:00:00,000 --> 00:00:02,680
+موسيقى
+
+2
+00:00:11,960 --> 00:00:14,340
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن 
+
+3
+00:00:14,340 --> 00:00:18,640
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى 
+
+4
+00:00:18,640 --> 00:00:22,240
+آله وصحبه وسلم أخذنا يا أخوات في المحاضرة الماضية 
+
+5
+00:00:22,240 --> 00:00:28,540
+الصفات التي تنقسم إلى قسمين صفات متضادة يعني كل 
+
+6
+00:00:28,540 --> 00:00:33,100
+صفة ولها ضدها وصفات ليس لها ضد أن هنا الصفات 
+
+7
+00:00:33,100 --> 00:00:36,940
+المتضادة واليوم إن شاء الله ناخد الصفات التي ليس 
+
+8
+00:00:36,940 --> 00:00:41,790
+لها ضِدّ مراجعة بسيطة لصفات المتضادة طبعًا كم صفة 
+
+9
+00:00:41,790 --> 00:00:46,510
+متضادة أخذناها في المحاضرة الماضية؟ يعني تقريبًا 
+
+10
+00:00:46,510 --> 00:00:53,790
+إحدى عشرة صفة عندنا الهامس وضده الجهر الشدة وضدها 
+
+11
+00:00:53,790 --> 00:00:58,550
+الرخاوة وبينهما التوسط الاستعلاء وضده الاستفال 
+
+12
+00:00:58,550 --> 00:01:04,430
+الأطباق وضده الانفتاح الإذلاق وضده الإصمات ما هي 
+
+13
+00:01:04,430 --> 00:01:11,590
+حروف الـ الـ الهامس مثلًا؟ حثّه شخص فسكت والجهر 
+
+14
+00:01:11,590 --> 00:01:16,570
+باقي حروف اللغة العربية وهي مجموعة في قوله عظمة و
+
+15
+00:01:16,570 --> 00:01:22,190
+ازنقار إن غضن ذي طلب جد الهمس صفة قوة ولا ضعف؟ ضعف 
+
+16
+00:01:22,190 --> 00:01:26,850
+و الجهر صفة قوة ننتقل إلى الصفة الثانية عندنا 
+
+17
+00:01:26,850 --> 00:01:31,830
+الشدة وضدها الرخاوة الشدة انحباس الصوت ولا النفس 
+
+18
+00:01:33,740 --> 00:01:36,860
+الصوت.. انحباس الصوت في المخرج عند النطق بحرف 
+
+19
+00:01:36,860 --> 00:01:40,820
+الشدة لقوة اعتماد الحرف على مخرجه ما هي حروف 
+
+20
+00:01:40,820 --> 00:01:50,700
+الشدة؟ أجد.. قط.. بكت وضدها اللي هي؟ الرخاوة..
+
+21
+00:01:50,700 --> 00:01:54,560
+ضدها الرخاوة وبينهم التوسط التوسط ما هو التوسط؟
+
+22
+00:01:57,940 --> 00:02:02,040
+اعتدال الصوت في المخرج عند النطق بحرف التوسط لعدم 
+
+23
+00:02:02,040 --> 00:02:07,260
+كمال انحباس فيه ما هي حروف التوسط؟ مجموعة في قوله 
+
+24
+00:02:07,260 --> 00:02:12,360
+لين عمرو الصفة المضادة للشدة هي صفة الرخوة وهي 
+
+25
+00:02:12,360 --> 00:02:17,560
+جريان الصوت في المخرج عند النطق بحرف الرخوة لضعف 
+
+26
+00:02:17,560 --> 00:02:22,890
+اعتماد الحرف على مخرجه ما هي حروف الرخوة؟ باقي حروف 
+
+27
+00:02:22,890 --> 00:02:26,790
+اللغة العربية باقي حروف اللغة العربية أو ممكن نقول 
+
+28
+00:02:26,790 --> 00:02:30,590
+حروف اللغة العربية نستثنى منها حروف الشدة اللي هي 
+
+29
+00:02:30,590 --> 00:02:35,870
+أجد قط بكت وحروف التوسط اللي هي لنعمر صفة الشدة 
+
+30
+00:02:35,870 --> 00:02:42,380
+صفة إيه؟ قوة الرقابة؟ بعض صفة التوسط؟ معتدلاً، مش 
+
+31
+00:02:42,380 --> 00:02:46,740
+محسوبًا، لا هي مع القوة ولا مع الضعف ننتقل إلى 
+
+32
+00:02:46,740 --> 00:02:51,100
+الصفة الثالثة المتضادة اللي هي صفة الاستعلاء و
+
+33
+00:02:51,100 --> 00:02:56,900
+ضدها الاستفال ما معنى الاستعلاء؟ ارتفاع أقصى اللسان 
+
+34
+00:02:56,900 --> 00:03:01,700
+إلى الحنك الأعلى عند النطق بحرف الاستعلاء ما هي 
+
+35
+00:03:01,700 --> 00:03:07,530
+حروف الاستعلاء؟ مجموعة في قوله خصة ضغط انقدر الصفة 
+
+36
+00:03:07,530 --> 00:03:12,750
+المضادة للاستعلاء هي صفة الاستفال وهي انخفاض 
+
+37
+00:03:12,750 --> 00:03:17,410
+اللسان إلى قاع الفم عند النطق بحرف الاستفال ما 
+
+38
+00:03:17,410 --> 00:03:21,940
+هي حروف الاستفال؟ باقي حروف اللغة العربية ونحن نرى 
+
+39
+00:03:21,940 --> 00:03:26,680
+هنا أن الصفات المتضادة تتنازع حروف اللغة العربية 
+
+40
+00:03:26,680 --> 00:03:30,720
+يعني لا يمكن أن يكون هناك في الحرف الواحد صفة 
+
+41
+00:03:30,720 --> 00:03:35,740
+الاستعلاء وصفة الاستفال أو صفة الشدة وصفة الرخاوة 
+
+42
+00:03:35,740 --> 00:03:41,460
+أو صفة الهمس وصفة الجهر إنما هي تتنازع ما بين كل 
+
+43
+00:03:41,460 --> 00:03:45,780
+صفة متضادة تتنازع حروف اللغة العربية وهناك صفات 
+
+44
+00:03:45,780 --> 00:03:51,310
+قوية وهناك صفات ضعيفة ننتقل إلى صفة الرابعة وهي 
+
+45
+00:03:51,310 --> 00:03:55,590
+صفة الإطباق وضدها الانفتاح ما معنى الإطباق يا 
+
+46
+00:03:55,590 --> 00:04:00,610
+أخوات؟ الالتصاق لغة أو التصاق طرف من اللسان 
+
+47
+00:04:00,610 --> 00:04:05,370
+بالحنك الأعلى عند النطق بحرف الإطباق ما هي حروف 
+
+48
+00:04:05,370 --> 00:04:15,210
+الإطباق؟ أربعة حروف الطاء والضاد والصاد والظاء يعني 
+
+49
+00:04:15,210 --> 00:04:19,830
+صاب ضاطة ضاء أربعة حروف هذه الحروف الأربعة لأنها 
+
+50
+00:04:19,830 --> 00:04:24,570
+تلتصق بالحنك الأعلى عند النطق بحرف الإطباق نسميها 
+
+51
+00:04:24,570 --> 00:04:27,810
+اللي هي صفة إطباق وصفة الإطباق صفة إيه يا أخوات 
+
+52
+00:04:27,810 --> 00:04:32,840
+قوة ولا ضعف؟ قوة وضدها الانفتاح ومعنى الانفتاح 
+
+53
+00:04:32,840 --> 00:04:36,120
+اللي هو الافتراك افتراك اللسان عن الحنك الأعلى 
+
+54
+00:04:36,120 --> 00:04:39,960
+إلى قاع الفم أو افتراك اللسان عن الحنك الأعلى 
+
+55
+00:04:39,960 --> 00:04:44,780
+عند النطق بحرف الـ إيه؟ بحرف الـ .. الانفتاح بينفتح 
+
+56
+00:04:44,780 --> 00:04:50,120
+وحروفه باقي حروف اللغة العربية وهو صفة ضعف ولا 
+
+57
+00:04:50,120 --> 00:04:56,340
+قوة؟ ضعف آخر صفتين اللي هي صفة الإذلاق وصفة 
+
+58
+00:04:56,340 --> 00:05:02,910
+الإصمات عكسه أو ضدهما من يعرف لنا الإذلاق.. خفة 
+
+59
+00:05:02,910 --> 00:05:06,050
+الحرف وسرعة النطق به.. آه يعني خفة الحرف وسرعة 
+
+60
+00:05:06,050 --> 00:05:10,410
+النطق به لخروجه من طرف اللسان أو الشفة أو الشفتين 
+
+61
+00:05:10,410 --> 00:05:15,110
+معه بمعنى أنه يخرج بسهولة ويسر وخفة من طرف 
+
+62
+00:05:15,110 --> 00:05:20,190
+اللسان أو الشفة أو الشفتين معه وحروف الإذلاق ما 
+
+63
+00:05:20,190 --> 00:05:28,280
+هي؟ ستة مجموعة في قوله فر من لبن الف والراء والميم والنون 
+
+64
+00:05:28,280 --> 00:05:33,840
+والراء والباء فر من لبن ثلاث حروف بتخرج من طرف اللسان 
+
+65
+00:05:33,840 --> 00:05:39,300
+نحن نقول اللي يخرج من طرف اللسان أو الشفة أو 
+
+66
+00:05:39,300 --> 00:05:42,880
+الشفتين معاها الحروف التي تخرج من طرف اللسان اللي 
+
+67
+00:05:42,880 --> 00:05:48,180
+هي النون واللام والراء اللي هي فر من لبن النون 
+
+68
+00:05:48,180 --> 00:05:53,620
+واللام والراء والحرف اللي يخرج من شفة واحدة اللي 
+
+69
+00:05:53,620 --> 00:05:59,830
+هو حرف الفاء والف والحرف.. الحرفان اللذان يخرجان من 
+
+70
+00:05:59,830 --> 00:06:04,070
+الشفتين معًا الـ m والـ b إذا حروف الإذلاق 
+
+71
+00:06:04,070 --> 00:06:09,450
+فر من لبّن الصفة المضادة للإذلاق هي صفة الإصمات 
+
+72
+00:06:09,450 --> 00:06:12,990
+أو الإصمات ما هو معناها؟ معناها المنع.. منع 
+
+73
+00:06:12,990 --> 00:06:17,810
+انفراد حروف الإصمات في أصول الكلمات الرباعية أو 
+
+74
+00:06:17,810 --> 00:06:22,610
+الخماسية يعني يمنع أن تنفرد حروف الإصمات كلها في 
+
+75
+00:06:22,610 --> 00:06:24,930
+أصول الكلمات الرباعية أو الخماسية يعني الكلمة 
+
+76
+00:06:24,930 --> 00:06:29,020
+الرباعية أو الخماسية لا يصح لها في اللغة العربية أن 
+
+77
+00:06:29,020 --> 00:06:34,360
+تكون كل حروفها من حروف الإصمات يعني لابد أن تكون 
+
+78
+00:06:34,360 --> 00:06:38,740
+فيها أقل شيء حرف من حروف الإذلاق اللي هو فر من لبن 
+
+79
+00:06:39,850 --> 00:06:44,730
+فإذا وجدت كلمة جميع حروفها حروف إصمات، ما معنى 
+
+80
+00:06:44,730 --> 00:06:49,530
+هذا؟ أن هذه الكلمة ليست عربية، بل هي إيش يا أخوات؟
+
+81
+00:06:49,530 --> 00:06:53,850
+معربة، يعني كانت فارسية ودخلت اللغة العربية، كانت 
+
+82
+00:06:53,850 --> 00:06:58,650
+يونانية ودخلت اللغة العربية، يعني صارت معربة، من 
+
+83
+00:06:58,650 --> 00:07:02,970
+يذكر لنا بعض الكلمات أو كلمة من الكلمات التي 
+
+84
+00:07:02,970 --> 00:07:07,620
+عُرّبت فصارت كأنها عربية، تفضلي أختك كلمة أستاذ 
+
+85
+00:07:07,620 --> 00:07:12,320
+عارفين أنه إحنا كلمة أستاذ يعني جميع حروفها حروف 
+
+86
+00:07:12,320 --> 00:07:17,860
+إصمات لأنه ليس لها جذر لا نقول أستاذ يؤستذ أستاذة 
+
+87
+00:07:17,860 --> 00:07:22,120
+فهو مؤستذ ما فيش فعلها فعل إنما هي كلمة جامدة 
+
+88
+00:07:22,120 --> 00:07:26,700
+جاءتنا من الفارسية أنها أستاذ يبقى هي بمعنى أستاذ 
+
+89
+00:07:26,700 --> 00:07:31,330
+عندنا كلمة مؤلم الأستاذ بمعنى المعلم والمعلم علم 
+
+90
+00:07:31,330 --> 00:07:37,290
+يعلمه تعليمًا فهو معلم وعليم وعلمان يعني إلها جذور 
+
+91
+00:07:37,290 --> 00:07:41,950
+لكن كلمة أستاذ ما لها إيش جذور كلمة أستاذ جامدة زي 
+
+92
+00:07:41,950 --> 00:07:50,230
+كلمة مثلًا computer، bus مثلًا computer، bus، 
+
+93
+00:07:50,230 --> 00:07:53,690
+bicycle مثلًا هذه الكلمات كلها أصبحت داخلة علينا 
+
+94
+00:07:53,690 --> 00:07:58,890
+يعني لا نقول مثلًا عن كلمة الكمبيوتر هي عربية لأن 
+
+95
+00:07:58,890 --> 00:08:05,310
+أقول عنها كمبترة ما تجيش أصلًا لأن هي جامدة جات 
+
+96
+00:08:05,310 --> 00:08:08,270
+بهذا الشكل من اللغات الثانية أو من اللغة 
+
+97
+00:08:08,270 --> 00:08:12,470
+الإنجليزية لذا ليست عربية لكنها أصبحت معربة يعني 
+
+98
+00:08:12,470 --> 00:08:17,210
+إذا أراد أي واحد منا يذهب إلى المحل الحاسوب يعني 
+
+99
+00:08:17,210 --> 00:08:20,510
+يقول بدي كمبيوتر أريد كمبيوتر مثلًا أو بكم هذا 
+
+100
+00:08:20,510 --> 00:08:23,910
+الكمبيوتر مثلًا إنما لا يقول.. حتى كلمة الحاسوب مع 
+
+101
+00:08:23,910 --> 00:08:27,910
+أنها عُربت صارت حاسوب يعني قليل من الناس من يقول 
+
+102
+00:08:27,910 --> 00:08:31,990
+عنه أنه إيه أنه حاسوب تعرف.. تعرف الناس عليه أن 
+
+103
+00:08:31,990 --> 00:08:38,330
+يقول حاسوب أو راديو أو تلفزيون أو مثلًا boss وهكذا 
+
+104
+00:08:38,330 --> 00:08:43,210
+من هذه الأمور الكلمات التي عُربت فكلمة أستاذ يعني 
+
+105
+00:08:43,210 --> 00:08:46,550
+على مدار التاريخ دخلت اللغة العربية وهي ليست 
+
+106
+00:08:46,550 --> 00:08:50,870
+عربية وصارت معربة يعني يتعامل معها الناس على أساس 
+
+107
+00:08:50,870 --> 00:08:54,970
+أنها كلمة عربية وهي في الأساس ليست عربية كذلك 
+
+108
+00:08:54,970 --> 00:09:03,870
+كلمة عسجد عسجد يعني كجميع حروفها إيه مصمّمة يعني 
+
+109
+00:09:03,870 --> 00:09:07,130
+ما فيش فيها حرف من حروف الإذلاق إذا هي ليست عربية 
+
+110
+00:09:07,130 --> 00:09:13,210
+ما معنى عسجد؟ عسجد يعني الذهب عسيد بمعناه الذهب، 
+
+111
+00:09:13,210 --> 00:09:17,030
+عندنا.. نحن في بلادنا بنستخدم كلمة ذهب، لكن هناك 
+
+112
+00:09:17,030 --> 00:09:22,530
+بعض الناس.. الدول ممكن يسمونه العسيد لأنها من لغة 
+
+113
+00:09:22,530 --> 00:09:26,910
+ثانية جاءت إلينا، هذه حروف الإصمات، لكن يا أخوات 
+
+114
+00:09:26,910 --> 00:09:32,950
+الإصمات والإذلاق كلاهما صفة قوة ولا ضعف ولا معتدلة؟ 
+
+115
+00:09:33,630 --> 00:09:37,550
+كلاهما متوسطة إذا ما هي الحروف المتوسطة عندنا من 
+
+116
+00:09:37,550 --> 00:09:42,190
+الصفات التي أخذناها ما هي الصفات المتوسطة؟ التوسط 
+
+117
+00:09:42,190 --> 00:09:47,150
+هي واحد الإذلاق والإصمات كلها صفات توسط ما هي صفات 
+
+118
+00:09:47,150 --> 00:09:52,250
+القوة التي أخذناها؟ الشدة والجهر والاستعلاء 
+
+119
+00:09:52,250 --> 00:09:57,150
+والإطباق بس هذه الصفات الأربع هل يمكن أن يكون في 
+
+120
+00:09:57,150 --> 00:10:01,030
+الحرف الواحد أكثر من صفة يعني ممكن الحرف الواحد 
+
+121
+00:10:01,030 --> 00:10:06,140
+يكون فيه ثلاث أربع خمس ست صفات أقل شيء يا أخوات لابد 
+
+122
+00:10:06,140 --> 00:10:09,080
+أن يوجد في الحرف الواحد خمس صفات اللي هي الخمس 
+
+123
+00:10:09,080 --> 00:10:12,580
+صفات المتضادة التي تتنازع حروف اللغة العربية 
+
+124
+00:10:12,580 --> 00:10:17,820
+وممكن أن تزيد توصل ست صفات أو سبع صفات من الصفات 
+
+125
+00:10:17,820 --> 00:10:21,840
+التي ليس لها ضِدّ والتي سوف ناخذها الآن إن شاء 
+
+126
+00:10:21,840 --> 00:10:27,040
+الله أخذنا الصفات المتضادة كل صفة وضدها منها 
+
+127
+00:10:27,040 --> 00:10:30,880
+القوية ومنها الضعيفة ومنها المعتدلة المتوسطة 
+
+128
+00:10:30,880 --> 00:10:35,560
+يعني وهناخد الآن الصفات التي ليس لها ضِدّ وهي 
+
+129
+00:10:35,560 --> 00:10:40,060
+يعني تسع صفات اللي هي الصفير والقلقلة والانحراف 
+
+130
+00:10:40,060 --> 00:10:45,520
+والتكرير واللين والخفاء والغنة والاستطالة تسع 
+
+131
+00:10:45,520 --> 00:10:49,240
+صفات الصفة الأولى التي سوف ناخذها هي صفة الـ 
+
+132
+00:10:49,240 --> 00:10:55,250
+يا أخوات صفة الصفير معنى الصفير الصوت الحاد يخرج صوتًا 
+
+133
+00:10:55,250 --> 00:10:59,670
+حادًا سواء كان يعني إنسان بـ بـ بـ بـ 
+
+134
+00:10:59,670 --> 00:11:03,710
+بلسانه يخرج هذا الصوت أو الصوت الحاد الذي يخرج من 
+
+135
+00:11:03,710 --> 00:11:08,310
+الثقب أحيانًا بعض النوافذ بيكون فيه رياح في الخارج 
+
+136
+00:11:08,310 --> 00:11:12,550
+نسمع الصفير بيخرج من بين الشفتين يسمى هذه صفير 
+
+137
+00:11:12,550 --> 00:11:17,820
+إذا الصفير من حيث اللغة هو الصوت الحاد وهو كصوت 
+
+138
+00:11:17,820 --> 00:11:21,700
+خارج من الثقب عند ضغط الهواء فيه يعني حتى لو جينا 
+
+139
+00:11:21,700 --> 00:11:28,600
+ببوصة فتحنا منها جزء بصورة معينة وضغطنا فيها 
+
+140
+00:11:28,600 --> 00:11:34,000
+الهواء بتخرج بخ الصفير أو الزامرة أو صوت حاد يسمى 
+
+141
+00:11:34,000 --> 00:11:38,900
+الصفير هذا من حيث اللغة أما من حيث الاصطلاح من
+
+142
+00:11:38,900 --> 00:11:44,300
+يعرف لنا الصفير من حيث الاصطلاح هو إيش؟ انحصار
+
+143
+00:11:45,490 --> 00:11:49,930
+انحصار الصوت بين طرف اللسان وفوقي الثانية يعني
+
+144
+00:11:49,930 --> 00:11:54,150
+انحصار الصوت في المخرج، الصوت ينحصر في مخرج حروف
+
+145
+00:11:54,150 --> 00:12:00,490
+معينة ما بين طرف اللسان وهذا وأطراف الثانية العليا
+
+146
+00:12:00,490 --> 00:12:05,090
+والسفلى بينحصر الصوت فبيخرج الصوت من هذا المكان
+
+147
+00:12:05,090 --> 00:12:09,450
+الضيق يعني بهذا الشكل، يعني أطراف الثانية العليا
+
+148
+00:12:09,450 --> 00:12:14,600
+والسفلى بتكون مع بعضها البعض واللسان ينساب من
+
+149
+00:12:14,600 --> 00:12:19,920
+الداخل بحيث يسمح للصوت بالانسياب من بين الفتحة
+
+150
+00:12:19,920 --> 00:12:23,220
+الضيقة ما بين أطراف الثانية العليا والسفلى يعني
+
+151
+00:12:23,220 --> 00:12:24,640
+اللي أقول هـ .. أس
+
+152
+00:12:28,660 --> 00:12:34,240
+الآن أطراف الثانية العليا والسفلى ملتصقات
+
+153
+00:12:34,240 --> 00:12:38,440
+في بعض، في هناك فتحة ضيقة ما بين أطراف الثانية
+
+154
+00:12:38,440 --> 00:12:42,820
+العليا والسفلى بينحصر الصوت ما بين طرف اللسان
+
+155
+00:12:42,820 --> 00:12:47,500
+وفوقي الثانية فتخرج منه حروف الصفير، فما هي حروف
+
+156
+00:12:47,500 --> 00:12:53,360
+الصفير يا أخوات؟ الصاد والسين والزاي، الصاد والسين
+
+157
+00:12:53,360 --> 00:13:02,370
+والزاي، يعني أس، اسمناجد أنه ينحصر الصوت ما بين طرف
+
+158
+00:13:02,370 --> 00:13:07,950
+اللسان وفوقي الثانية، هذه الصفة الصفية، ووصف الصفير 
+
+159
+00:13:07,950 --> 00:13:14,720
+طبعًا كما يقول الصينيون، تشبه صوت سرب الجراد، الجراد طبعًا
+
+160
+00:13:14,720 --> 00:13:20,060
+يلاقوا عندما يكونوا سربًا بيخرجوا صوتًا يشبهوا صوت
+
+161
+00:13:20,060 --> 00:13:28,060
+الحرف الـ s، يعني الـ s يشبه صوت سرب الجراد، الـ z يشبه
+
+162
+00:13:28,060 --> 00:13:32,720
+صوت النحل عندما يكون في نحل أو سرب نحل يسير في
+
+163
+00:13:32,720 --> 00:13:38,260
+الهواء بنسمعه هذا حرف الزاي، والصاد بيشبه صوت الـ oars
+
+164
+00:13:38,260 --> 00:13:43,200
+طبعًا، تثبت يا أخوات هذه الصفة اللي هي صفة
+
+165
+00:13:43,200 --> 00:13:48,580
+الصفير في جميع أحوال الحروف سواء كانت ساكنة يعني
+
+166
+00:13:48,580 --> 00:13:53,520
+حرف السين والصاد والزاي، تشبه يعني، تثبت صفة الصفير
+
+167
+00:13:53,520 --> 00:14:01,150
+له في جميع أحوالهممكن يكون ساكن، الصالحين، السائلين
+
+168
+00:14:01,150 --> 00:14:08,130
+مثلًا، بيكون ساكن أو متحرك، سأل سائل، صالح حرف متحرك
+
+169
+00:14:08,130 --> 00:14:12,350
+أو في وصل الكلمة أو في آخر الكلمة، يبقى في جميع
+
+170
+00:14:12,350 --> 00:14:18,310
+أحوال الحرف، الحرفين، السين والصاد والزاي، سواء كان ساكنًا أو
+
+171
+00:14:18,310 --> 00:14:25,270
+متحركًا، متوسطًا أو متطرفًا، تثبت فيه صفة الصفير ولكن
+
+172
+00:14:25,270 --> 00:14:30,510
+بتكون أقوى عندما يكونوا ساكنًا أو ساكنًا مشددًا، مثال
+
+173
+00:14:30,510 --> 00:14:38,450
+ذلك كلمة الصالحين، الصالحين حرف الصاد يعني مشدد
+
+174
+00:14:38,450 --> 00:14:42,970
+نتيجة الإضغام ما بين اللام والصاد، اللام المضغمة
+
+175
+00:14:42,970 --> 00:14:49,430
+نقول الصالحين، فالصاد تثبت فيه صفة الصفير كذلك كلمة
+
+176
+00:14:49,430 --> 00:14:54,990
+ثانية واصبر صبرًا جميلًا، واصبر حرف الصاد في واصبر
+
+177
+00:14:54,990 --> 00:15:00,450
+أيضًا في صفة الصفير، الساعة الساعة، إيش كمان في
+
+178
+00:15:00,450 --> 00:15:08,110
+كلمات؟ فاستمع والزاجرات، زجرة، فإذا حرف السين والصاد
+
+179
+00:15:08,110 --> 00:15:13,890
+والزاي هي حروف الصفير، تخرج صوتًا حادًا عند نطقه، تثبت
+
+180
+00:15:13,890 --> 00:15:18,850
+صفة الصفير في جميع أحوالها، طيب الآن يا أخوات، صفة
+
+181
+00:15:18,850 --> 00:15:24,270
+الصفير هل هي صفة قوة ولا صفة ضعف؟ صفة الصفير صفة
+
+182
+00:15:24,270 --> 00:15:28,150
+قوة، الصوت الحاد حتى يعني، إذا أراد إنسان أن ينبه
+
+183
+00:15:28,150 --> 00:15:34,670
+إنسان بيقول أس أو از، فهذا الصوت الحاد بيسمع لذلك
+
+184
+00:15:34,670 --> 00:15:39,590
+صفة الصفير هي صفة قوة، ننتقل يا أخوات إلى الصفة
+
+185
+00:15:39,590 --> 00:15:44,710
+الثانية التي يعني ليس لها ضد، لو قلنا صحيح صفة
+
+186
+00:15:44,710 --> 00:15:49,930
+الصفير ما هو ضدها؟ ليس لها ضد .. ليس مثل الصفات
+
+187
+00:15:49,930 --> 00:15:54,570
+الماضية اللي هي الهمس والجهر والشدة، ضدها رفاوة
+
+188
+00:15:54,570 --> 00:15:58,830
+التوسط، الاستعلاء ضده الاستفال، وهاكذا، إنما هذه صفة
+
+189
+00:15:58,830 --> 00:16:03,270
+لوحدها ولها حروف محددة، مطلوب مننا أن نعرف صفة
+
+190
+00:16:03,270 --> 00:16:08,670
+الصفير وكيف ننطقه بالصفير أو نخرجه من مكانه، وما هي
+
+191
+00:16:08,670 --> 00:16:13,440
+حروفه؟ الصفة الثانية يا أخوات هي صفة الـ ... القلقلة
+
+192
+00:16:13,440 --> 00:16:19,200
+صفة ليس لها ضد، إنما هي صفة القلقلة، والقلقلة من
+
+193
+00:16:19,200 --> 00:16:24,080
+الاضطراب والتحريك، يعني نقول تقلقل الشيء بمعنى
+
+194
+00:16:24,080 --> 00:16:28,580
+اضطربه واتحرك، يوجد قلاقل في البلد الفلانية يعني
+
+195
+00:16:28,580 --> 00:16:33,240
+اضطرابات ومشاكل في البلد الفلانية، هذا من حيث اللغة
+
+196
+00:16:33,240 --> 00:16:36,980
+أما من حيث الاصطلاح ما معنى القلقلة يا أخوات؟
+
+197
+00:16:36,980 --> 00:16:39,200
+اصطلاحًا، فضلي
+
+198
+00:16:43,840 --> 00:16:48,440
+أحسنت، اضطراب المخرج عند النطق بحرف القلقلة حتى
+
+199
+00:16:48,440 --> 00:16:55,720
+يسمع له نبرة قوية، المخرج يضطرب عندما نقول مثلًا أب
+
+200
+00:16:55,720 --> 00:17:02,900
+في اضطراب وانحصار للصوت وللنفس، فيضغط المخرج، يغلق
+
+201
+00:17:02,900 --> 00:17:07,140
+ثم بعد ذلك ينفتح المخرج فتخرج منه النبرة التي
+
+202
+00:17:07,140 --> 00:17:11,770
+نسميها نحن الـ ... القلقلة، إذا تعريف القلقلة هو
+
+203
+00:17:11,770 --> 00:17:17,010
+اضطراب المخرج عند النطق بأحد حروف القلقلة حتى يسمع
+
+204
+00:17:17,010 --> 00:17:23,490
+له نبرة قوية، فما هي حروف القلقلة يا أخوات؟ مجموعة
+
+205
+00:17:23,490 --> 00:17:28,930
+في قوله خطوب جن هي خمس حروف، عندما أقول مثلًا أنا
+
+206
+00:17:28,930 --> 00:17:35,860
+أُقِقُ، أُقِقُ فيها قلقلة ولا لا؟ هذه القلقلة أُقِقُ أو الحق
+
+207
+00:17:35,860 --> 00:17:41,940
+أو قل أعوذ برب الفلق، فهذه الأُقِقُ تسمى إيش؟ تسمى
+
+208
+00:17:41,940 --> 00:17:48,600
+قلقلة، وهو ناتج عن انحباس صفتي الصوت والنفس، يعني
+
+209
+00:17:48,600 --> 00:17:52,200
+اجتماع الصفتي الشدة والجهر، الشدة انحباس الصوت
+
+210
+00:17:52,200 --> 00:17:57,620
+والجهر انحباس النفس في حروف القلقلة، فلمّا يحبس
+
+211
+00:17:57,620 --> 00:18:04,180
+النفس ويحبس الصوت ثم بعد ذلك يفتح المخرج فتخرج منه
+
+212
+00:18:04,180 --> 00:18:11,120
+النبرة، يعني عندما أقول مثلًا أنا أغلق
+
+213
+00:18:11,120 --> 00:18:16,840
+المخرج وانحبس النفس وانحبس الصوت ثم يفتح المخرج
+
+214
+00:18:16,840 --> 00:18:23,640
+فتخرج منه النبرة التي نسميها نحن القلقلة، كذلك حرف
+
+215
+00:18:23,640 --> 00:18:33,910
+الأق أو إب، إج، إد، كل هذه تسمى إيه؟ تسمى حروف قلقلة،
+
+216
+00:18:33,910 --> 00:18:37,850
+لو سألنا يعني ما هي سر القلقلة؟
+
+217
+00:18:40,510 --> 00:18:44,270
+أحسنتِ، اجتماع صفتي الشدة والجهر، الشدة فيها إيش يا
+
+218
+00:18:44,270 --> 00:18:48,750
+أخوات؟ انحباس الصوت، والجهر انحباس النفس، لمّا انحبست
+
+219
+00:18:48,750 --> 00:18:55,170
+الصوت والنفس بعد ذلك يخرج أو يفتح المخرج فتخرج منه
+
+220
+00:18:55,170 --> 00:19:00,490
+النبرة، وكما قلنا سابقًا بتثبت القلقلة في جميع أحوال
+
+221
+00:19:00,490 --> 00:19:05,290
+حروف القلقلة، ولكن بيكون أَثْبَت يعني عندما يكون ساكنًا أو
+
+222
+00:19:05,290 --> 00:19:12,230
+متحرك، مثلًا عندما يكون في وسط الكلمة أو في آخر
+
+223
+00:19:12,230 --> 00:19:17,430
+الكلمة، لكن بيكون ثابت وواضح جدًا عندما يكون ساكنًا أو
+
+224
+00:19:17,430 --> 00:19:22,780
+مُشَدَّدًا، وعندما يكون متحرك بتكون في أصل القلقلة، يعني
+
+225
+00:19:22,780 --> 00:19:27,080
+عندما نقول قال في أصل القلقلة لكن غير عن الحق
+
+226
+00:19:27,080 --> 00:19:31,800
+القلقلة واضحة وكبيرة، أما بالنسبة لأقسام القلقلة يا
+
+227
+00:19:31,800 --> 00:19:36,060
+أخوات، تنقسم القلقلة إلى عدة أقسام، ما هي أقسام
+
+228
+00:19:36,060 --> 00:19:44,020
+القلقلة؟ أمي عارفة، تفضلي أختك، إذا في عندنا ثلاث أقسام
+
+229
+00:19:44,020 --> 00:19:50,420
+قلقلة صغيرة، وقلقلة كبرى، وقلقلة أكبر، أما القلقلة
+
+230
+00:19:50,420 --> 00:19:55,720
+الصغيرة فهو إذا جاء أحد حروف القلقلة ساكنًا متوسطًا
+
+231
+00:19:55,720 --> 00:20:00,420
+في الكلمة تكون قلقلة صغيرة، من ياتي بأمثلة على
+
+232
+00:20:00,420 --> 00:20:05,420
+القلقلة الصغيرة؟ فضلي أختي، سبحان .. سبحان فيها ..
+
+233
+00:20:05,420 --> 00:20:10,420
+فيها قلقلة لكن ليست مثل تبت يد أبي لهب، وتب .. بأ
+
+234
+00:20:10,420 --> 00:20:16,680
+لأن عندما أقول اب بأ قوية، لكن سبحان فيها قلقلة لكن
+
+235
+00:20:16,680 --> 00:20:20,200
+أصلًا .. يعني قليلة، سبحان الذي أسرى بعبده ليلًا
+
+236
+00:20:20,200 --> 00:20:24,760
+سبحان فيها قلقلة ولكنها بتكون صغيرة لأنها جاءت
+
+237
+00:20:24,760 --> 00:20:29,060
+الحرف القلقلة اللي هو الباء في وسط الكلمة، كذلك
+
+238
+00:20:29,060 --> 00:20:31,380
+كلمة مقتدرًا
+
+239
+00:20:33,050 --> 00:20:37,330
+مُقْتَدِرَة فيها قلقلة، ولكن القلقلة بتكون إيش يا أخوات؟
+
+240
+00:20:37,330 --> 00:20:42,830
+القلقلة صغيرة لأن حرف القلقلة جاء متوسطًا هنا
+
+241
+00:20:42,830 --> 00:20:50,310
+المُجْرِمُون، حرف الإج، حرف الإج في قلقلة صغيرة لأنه جاء
+
+242
+00:20:50,310 --> 00:20:55,840
+متوسطًا، كذلك من يقرأ هذه الكلمة؟ فضلي، قد أفلح
+
+243
+00:20:55,840 --> 00:20:59,640
+المؤمنون، طبعًا قد أفلح المؤمنون قد جاءت في آخر
+
+244
+00:20:59,640 --> 00:21:03,580
+الكلمة، صح لكنها في حالة الوصل، بتكونش آخر الكلمة
+
+245
+00:21:03,580 --> 00:21:07,760
+قد أفلح المؤمنون، يعني قد أفلح المؤمنون في عندنا
+
+246
+00:21:07,760 --> 00:21:11,640
+قلقلة صغيرة في حالة الوصل، لكن لو وقفنا عليها من
+
+247
+00:21:11,640 --> 00:21:15,480
+باب الاختبار أو الاضطرار، واحد وقف مثلًا من باب
+
+248
+00:21:15,480 --> 00:21:21,300
+اضطرارًا أو اختبارًا، قال قد لكن ما نفعش نقول قد ق،
+
+249
+00:21:21,300 --> 00:21:24,240
+بعدين نقول أفلح المؤمنون، لأنه هذا .. يعني
+
+250
+00:21:24,240 --> 00:21:28,260
+الابتداء قبيح والوقف قبيح، لذلك لابد أن نرجع، لكن
+
+251
+00:21:28,260 --> 00:21:34,280
+من باب الاختبار، يعني لو قال المدرس للطالب اسكت أو
+
+252
+00:21:34,280 --> 00:21:38,660
+قف عند كلمة قد ق، هيبين أنه عندنا .. عندنا هتكون
+
+253
+00:21:38,660 --> 00:21:44,430
+القلقلة كبرى، لكن قد أفلح تكون القلقلة صغيرة، وهذا
+
+254
+00:21:44,430 --> 00:21:48,390
+يا أخوات يعني عادة ما يأتي بالامتحان يعني بيقول لك
+
+255
+00:21:48,390 --> 00:21:56,710
+أن حرف الدال في قد حالة الوصل قلقلة كبرى، صح ولا
+
+256
+00:21:56,710 --> 00:22:00,670
+غلط؟ بيكون طبعًا هي غلط، وإنما هو قلقلة صغيرة في
+
+257
+00:22:00,670 --> 00:22:04,930
+الوصل، لكن لو وقفنا عليه اضطرارًا أو اختبارًا بيكون
+
+258
+00:22:04,930 --> 00:22:07,430
+قلقلة كبرى
+
+259
+00:22:08,730 --> 00:22:12,590
+القلقلة الثانية أو النوع الثاني، القسم الثاني ما هو
+
+260
+00:22:12,590 --> 00:22:15,390
+يا أخوات؟ اللي هي القلقلة الكبرى، أخذنا القلقلة
+
+261
+00:22:15,390 --> 00:22:19,850
+الصغيرة، القسم الثاني قلقلة كبرى، من يعرف لها
+
+262
+00:22:19,850 --> 00:22:23,870
+القلقلة الكبرى؟ يعني إذا جاء .. فضلي
+
+263
+00:22:27,470 --> 00:22:32,550
+إذا جاء أحد حروف القلقلة ساكنًا مخففًا موقوفًا عليه
+
+264
+00:22:32,550 --> 00:22:38,810
+يسمى قلقلة كبرى، لابد أن يكون ساكنًا وموقوفًا، والسكون
+
+265
+00:22:38,810 --> 00:22:43,970
+كذلك مخفف، في عنده مخفف وفي عنده مثقل، المثقل هو
+
+266
+00:22:43,970 --> 00:22:48,090
+المشدد، لأن المشدد هو عبارة عن حرفين مضغمين مع
+
+267
+00:22:48,090 --> 00:22:51,860
+بعضهم البعض، يعني حرف ساكن وحرف متحرك اضغموا فصار
+
+268
+00:22:51,860 --> 00:22:58,380
+مُشَدَّدًا، لكن عندما يكون فقط ساكن عليه سكون ووقفنا عليه
+
+269
+00:22:58,380 --> 00:23:04,560
+يسمى قلقلة كبرى، ممكن يا أخوات يكون هو مضمومًا أو
+
+270
+00:23:04,560 --> 00:23:09,160
+مفتوحًا أو متحركًا لكن عند الوقف عليه نسكنه لأن العرب
+
+271
+00:23:09,160 --> 00:23:13,620
+كما نقول لا يبدأون الكلام بساكن ولا يقفون على
+
+272
+00:23:13,620 --> 00:23:17,820
+متحرك، مثال ذلك قُلْ هُوَ اللَّهُ أَحَدٌ، هي منونة
+
+273
+00:23:17,820 --> 00:23:21,520
+أَحَدٌ، لو وقفنا عليه بسلطة قُلْ هُوَ اللَّهُ أَحَدٌ
+
+274
+00:23:21,520 --> 00:23:26,200
+قال .. قال إيه؟ قال كبرى، لكن لو وصلناها قُلْ هُوَ
+
+275
+00:23:26,200 --> 00:23:30,180
+اللَّهُ أَحَدٌ، اللَّهُ الصَّمَد فيها .. يعني نستمر
+
+276
+00:23:30,180 --> 00:23:35,490
+ونتيجة التقاء الساكن أَحَدٌ اللَّهُ الصَّمَد نتخلص من
+
+277
+00:23:35,490 --> 00:23:40,670
+التقاء الساكنين بإيش؟ بالكسر، لكن هنا مثلًا بتسمى
+
+278
+00:23:40,670 --> 00:23:46,460
+قلقلق كبرى، قلقلق كبرى مثلًا قل أعوذ برب الفلق هي
+
+279
+00:23:46,460 --> 00:23:51,820
+أصلًا برب الفلقي، من شر ما خلق مكسورة، لكن عند الوقف
+
+280
+00:23:51,820 --> 00:23:56,880
+عليه نقول قل أعوذ برب الفلق، فيها القلقلة، من شر ما 
+
+281
+00:23:56,880 --> 00:24:03,020
+خلق فيها أيضا قلقلة والله بما يعملون محيط أيضا
+
+282
+00:24:03,020 --> 00:24:08,220
+كلمة محيط القلقلة مالها كبرى لأنه وقفنا على حرف
+
+283
+00:24:08,220 --> 00:24:13,640
+القلقلة ساكنا متطرفا يسمى قلقلة صغرة أيضا كلمة
+
+284
+00:24:13,640 --> 00:24:19,390
+هدمان يقراها الغيب .. من يقرأ الغيب ويوضح القلقلة
+
+285
+00:24:19,390 --> 00:24:24,530
+.. اه تفضلي أخوات .. تفضلي .. الغيب .. الغيب ..
+
+286
+00:24:24,530 --> 00:24:28,210
+الغيب .. الغيب .. الغيب .. الغيب .. الغيب .. الغيب
+
+287
+00:24:28,210 --> 00:24:29,070
+الغيب .. الغيب .. الغيب .. الغيب .. الغيب .. الغيب
+
+288
+00:24:29,070 --> 00:24:29,170
+.. الغيب .. الغيب .. الغيب .. الغيب .. الغيب ..
+
+289
+00:24:29,170 --> 00:24:34,150
+الغيب .. الغيب أيوة البروج ما بنفع يا إخوان تقول
+
+290
+00:24:34,150 --> 00:24:55,110
+البروج شششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششش
+
+291
+00:24:58,950 --> 00:25:05,610
+البروج .. البروج فيها قلقلة كبرى لأن حرف الجيم جاء
+
+292
+00:25:05,610 --> 00:25:11,310
+متطرفا فبيلتسق الوسط اللسان بالحنك الأعلى وبيمنع
+
+293
+00:25:11,310 --> 00:25:17,090
+النفس والصوت ثم بعد ذلك يفتح مخرج حرف الجيم فتخرج
+
+294
+00:25:17,090 --> 00:25:24,140
+النبرة فنقول البروج كذلك أحدكما قلنا قل هو الله
+
+295
+00:25:24,140 --> 00:25:30,740
+أحد أحد طبعا قلقلة كبرى في أي الحروف في الحرف الذي
+
+296
+00:25:30,740 --> 00:25:35,060
+وقفنا عليه إن هو حرف الدال أو حرف الجيم أو الباء أو
+
+297
+00:25:35,060 --> 00:25:39,850
+الطاء أو القاف القسم الثالث يا أخوات هو القلقلة
+
+298
+00:25:39,850 --> 00:25:46,170
+الأكبر أخذنا قلقلة صغر قلقلة كبر قلقلة أكبر القلقلة
+
+299
+00:25:46,170 --> 00:25:51,990
+الأكبر وهو إذا جاء أحد حروف القلقلة ساكنا مشددا أو
+
+300
+00:25:51,990 --> 00:25:57,130
+مثقلا كلها مرادفات مشددا أو مثقلا موقوف عليه بنسمي
+
+301
+00:25:57,130 --> 00:26:02,810
+قلقلة أكبر لأنه اتشد يعني قوة لذلك عندنا الكثير من
+
+302
+00:26:02,810 --> 00:26:08,890
+الكلمات من ضمنها الحق بدأت تخرج القلقلة من كلمة
+
+303
+00:26:08,890 --> 00:26:15,170
+الحق قوية لأن القاف مالها؟ القاف مشددة الحق من
+
+304
+00:26:15,170 --> 00:26:19,050
+يقراها الحق مع بيان القلقلة اللي فيها؟ فضل أختي
+
+305
+00:26:19,050 --> 00:26:26,570
+الحق من يعيد الكلمة هذه؟ فضل أختي الحق لازم نبينها
+
+306
+00:26:26,570 --> 00:26:34,710
+يعني ممكن بعض الأخوات تخفيها تقول الحقب الصوت خافت
+
+307
+00:26:34,710 --> 00:26:39,730
+فلا تخرجيها طبعا بتكون لابد أن تظهرها فتقول الحق
+
+308
+00:26:39,730 --> 00:26:47,530
+لأن فيها قلقلة أكبر تبت يد أبي لهب وتب و تب فيها
+
+309
+00:26:47,530 --> 00:26:55,110
+أيه؟ قلقلة من يقرأ هذه ال .. و تب؟ فضل أخت و تب طيب
+
+310
+00:26:55,110 --> 00:27:02,890
+الحج .. الحج من يقرأ الحج؟ فضل أخت الحج .. طب نفع
+
+311
+00:27:02,890 --> 00:27:08,710
+نقول الحج .. الحج يعني النفس ماشي و هذا طبعا ليه
+
+312
+00:27:08,710 --> 00:27:15,550
+صح إنما نقول الحج .. الحج طيب أشد .. إذا هذه أقسام
+
+313
+00:27:15,550 --> 00:27:20,390
+القلقلة في عندنا كذلك يا أخوات مراتب القلقلة مراتب
+
+314
+00:27:20,390 --> 00:27:24,070
+القلقلة يعني نعكسها أقوى مرتبة اللي هي القلقلة
+
+315
+00:27:24,070 --> 00:27:28,870
+الأكبر المرتبة الثانية القلقلة الكبرى المرتبة
+
+316
+00:27:28,870 --> 00:27:32,430
+الثالثة القلقلة الصغرى والمرتبة الرابعة اللي هي
+
+317
+00:27:32,430 --> 00:27:37,470
+أصل القلقلة الحرف المتحرك إذا ما هي مراتب القلقلة؟
+
+318
+00:27:37,470 --> 00:27:42,050
+كم مرتبة؟ أربع المرتبة الأولى إذا جاء أحد حروف
+
+319
+00:27:42,050 --> 00:27:48,510
+القلقلة ساكنا مثقلا متطرفا موقوفا عليه عند مثل أشد
+
+320
+00:27:48,510 --> 00:27:55,940
+وتبالحق هذه بتكون قلقلة أكبر
+
+321
+00:28:21,150 --> 00:28:25,170
+المرتبة الثالثة هي القلقلة الصغرى وهو إذا جاء أحد
+
+322
+00:28:25,170 --> 00:28:29,670
+حروف القلقلة ساكنا متوسطا في الكلمة يكون عندنا
+
+323
+00:28:29,670 --> 00:28:32,970
+القلقلة .. إيش؟ قلقلة .. مرتبة ثالثة اللي هي
+
+324
+00:28:32,970 --> 00:28:36,030
+القلقلة الصغرى ما أنا آتية بمثال على القلقلة الصغرى
+
+325
+00:28:36,030 --> 00:28:38,370
+مقتدرة
+
+326
+00:28:39,360 --> 00:28:44,380
+مقتذرة فيها قلقلة صغرى سبحان .. سبحان فيها قلقلة
+
+327
+00:28:44,380 --> 00:28:49,060
+صغرى المجرمون .. المجرمون فيها قلقلة ولكن بتكون
+
+328
+00:28:49,060 --> 00:28:55,400
+قلقلة صغرى من أي مرتبة هذه المجرمون مرتبة الثالثة
+
+329
+00:28:55,400 --> 00:29:00,420
+قد أفلح المؤمنون برضه مرتبة الثالثة لكن لو وقفنا
+
+330
+00:29:00,420 --> 00:29:05,000
+على كلمة قد بتكون المرتبة إيه؟ المرتبة الثانية اللي
+
+331
+00:29:05,000 --> 00:29:09,380
+هي الكبرى طب آخر مرتبة اللي هي المرتبة رقم أربعة
+
+332
+00:29:09,380 --> 00:29:16,020
+هي ده الحرف المتحرك باعتبار إن فيه أصل القلقلة مثل
+
+333
+00:29:16,020 --> 00:29:22,000
+طبعة طبعة .. إيش فيها طبعة؟ المتحركة حرف الطبعة
+
+334
+00:29:22,000 --> 00:29:27,440
+مفتوح فيها أصل القلقلة لكن ليس مثل يطبع .. يطبع
+
+335
+00:29:27,440 --> 00:29:31,440
+حرف الطبعة .. الطبعة ساكن يا قلقلة صغرى أو محيط
+
+336
+00:29:31,440 --> 00:29:38,560
+قلقلة أكبر أو قلقلة كبرى أو مثلا الحق قلقلة أكبر
+
+337
+00:29:38,560 --> 00:29:43,920
+كذلك يقولوا .. يقولوا حرف القاف في أصل القلقلة من
+
+338
+00:29:43,920 --> 00:29:47,550
+أي مرتبة هذا يا أخوات؟ من القلقلة .. من المرتبة
+
+339
+00:29:47,550 --> 00:29:52,590
+الرابعة بصير حرف الباء في كلمة بصير في قلقلة أصل
+
+340
+00:29:52,590 --> 00:29:57,250
+القلقلة بيكون هو من المرتبة الرابعة آخر شيء عندنا يا
+
+341
+00:29:57,250 --> 00:30:02,930
+أخوات اللي هي كيفية أداء القلقلة كيف نؤدي القلقلة
+
+342
+00:30:02,930 --> 00:30:07,390
+هل بتكون القلقلة مائلة إلى الفتح ولا مائلة إلى
+
+343
+00:30:07,390 --> 00:30:11,890
+حركة الحرف الذي قبلها في عندنا رأيها الرأي الأول
+
+344
+00:30:11,890 --> 00:30:15,690
+يا أخوات أن القلقلة طبعا هو مختلف علماء فيها الرأي
+
+345
+00:30:15,690 --> 00:30:20,650
+الأول أن القلقلة تكون مائلة إلى الفتح دائما مثال
+
+346
+00:30:20,650 --> 00:30:28,320
+ذلك مثلا الحق مائلة إلى الفتحة محيط مائلة إلى
+
+347
+00:30:28,320 --> 00:30:33,220
+الفتحة أحد مائلة إلى الفتحة أحد .. مايقولش أحد ولا
+
+348
+00:30:33,220 --> 00:30:38,000
+أحد دي إنما كلها مائلة إلى الفتحة لذلك و هذا الرأي
+
+349
+00:30:38,000 --> 00:30:43,320
+الذي يمينه ليه العلماء أن حركة أو القلقلة دائما
+
+350
+00:30:43,320 --> 00:30:47,620
+بتكون مائلة إلى الفتحة القول الثاني أخذ به أيضا بعض
+
+351
+00:30:47,620 --> 00:30:51,560
+العلماء أنها تكون مائلة إلى حركة الحرف اللي قبلها
+
+352
+00:30:51,560 --> 00:30:55,720
+إذا كانت الحركة الحرف اللي قبلها مفتوحة بتكون
+
+353
+00:30:55,720 --> 00:31:01,500
+مائلة إلى الفتح مثال ذلك أقرب .. أقرب فحرف القاف
+
+354
+00:31:01,500 --> 00:31:06,080
+ساكن والهمزة قبله متحرك مفتوح فبكون مائلة إلى
+
+355
+00:31:06,080 --> 00:31:10,240
+الفتح هنا أقول أقه .. أقرب .. أقرب بتكون مائلة
+
+356
+00:31:10,240 --> 00:31:15,470
+إلى الفتح إذا كانوا مضموم يعني هو ساكن مسبوك بحرف
+
+357
+00:31:15,470 --> 00:31:21,790
+مضموم مثل سبحان سبحان فنقول سبق سبحان الباء مائلة
+
+358
+00:31:21,790 --> 00:31:25,690
+أو حركة القلقلة مائلة إلى إيه؟ إلى الضم لأن حرف
+
+359
+00:31:25,690 --> 00:31:30,770
+البا اللي جاب الحرف الصين مضموم سبحانو أو يكون
+
+360
+00:31:30,770 --> 00:31:34,270
+مائل إلا كسر لو كان الحرف اللي قابله مكسور مثال
+
+361
+00:31:34,270 --> 00:31:40,730
+ذلك اقرأ اقرأ فالحرف القاف ساكن وما قبله إيش ماله
+
+362
+00:31:40,730 --> 00:31:45,030
+مكسور فبتكون في عندنا مائل إلا كسر هدول يا أخوات
+
+363
+00:31:45,030 --> 00:31:50,050
+هو ال .. ال .. يعني الوضعين اللي فيه .. فيه أداء
+
+364
+00:31:50,050 --> 00:31:55,210
+القلقلة آخر شيء عندنا صفة القلقلة هل هي صفة قوة ولا
+
+365
+00:31:55,210 --> 00:31:59,490
+صفة ضعف قوة صبرا، إذا في عندنا الحكمين اللي أخذناهم
+
+366
+00:31:59,490 --> 00:32:04,250
+اليوم اللي هي الصفرة وهي صفة قوة والقلقلة هي صفة
+
+367
+00:32:04,250 --> 00:32:07,790
+ضعف إن شاء الله في المحاضرات القادمة نكمل الصفات
+
+368
+00:32:07,790 --> 00:32:11,910
+المتضادة ونكتفي بهذا القدر ون .. وبارك الله
+
+369
+00:32:11,910 --> 00:32:15,010
+فيكم وجزاكم الله خير والسلام عليكم ورحمة الله و
+
+370
+00:32:15,010 --> 00:32:15,490
+بركاته
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..add55d84581b489abd20a23cd545365225ba6618
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/ph1VHLnLb3M_postprocess.srt
@@ -0,0 +1,1480 @@
+1
+00:00:00,000 --> 00:00:02,680
+موسيقى
+
+2
+00:00:11,960 --> 00:00:14,340
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+3
+00:00:14,340 --> 00:00:18,640
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+4
+00:00:18,640 --> 00:00:22,240
+آله وصحبه وسلم أخذنا يا أخوات في المحاضرة الماضية
+
+5
+00:00:22,240 --> 00:00:28,540
+الصفات التي تنقسم إلى قسمين صفات متضادة يعني كل
+
+6
+00:00:28,540 --> 00:00:33,100
+صفة ولها ضدها وصفات ليس لها ضد أن هنا الصفات
+
+7
+00:00:33,100 --> 00:00:36,940
+المتضادة واليوم ان شاء الله ناخد الصفات التي ليس
+
+8
+00:00:36,940 --> 00:00:41,790
+لها ضدمراجعة بسيطة لصفات المتضادة طبعا كام صفة
+
+9
+00:00:41,790 --> 00:00:46,510
+متضادة أخدناها في المحاضرة الماضية؟ يعني تقريبا
+
+10
+00:00:46,510 --> 00:00:53,790
+إحدى عشر صفة عندنا الهامس و ضده الجهر الشدة و ضدها
+
+11
+00:00:53,790 --> 00:00:58,550
+الرخاوة و بينهما التوسط الاستعلاء و ضده الاستفال
+
+12
+00:00:58,550 --> 00:01:04,430
+الأطباق و ضده الانفتاح الإذلاق و ضده الإصمات ما هي
+
+13
+00:01:04,430 --> 00:01:11,590
+حروف ال .. ال .. الهامس مثلا؟حثّه شخص فسكت و الجهر
+
+14
+00:01:11,590 --> 00:01:16,570
+باقي حروف اللغة العربية و هي مجموعة في قوله عظمة و
+
+15
+00:01:16,570 --> 00:01:22,190
+ازنقار ان غضن ذي طلب جد الهمس صفة قوة ولا ضعف؟ ضعف
+
+16
+00:01:22,190 --> 00:01:26,850
+و الجهر صفة قوة ننتقل إلى الصفة الثانية عندنا
+
+17
+00:01:26,850 --> 00:01:31,830
+الشدة و ضدها الرخاوة الشدة انحباس الصوت ولا النفس
+
+18
+00:01:33,740 --> 00:01:36,860
+الصوت .. انحباس الصوت في المخرج عند النطق بحرف
+
+19
+00:01:36,860 --> 00:01:40,820
+الشدة لقوة اعتماد الحرف على مخرجه ما هي حروف
+
+20
+00:01:40,820 --> 00:01:50,700
+الشدة؟ أجد .. قط .. بكت و ضدها اللي هي؟ الرخاوة ..
+
+21
+00:01:50,700 --> 00:01:54,560
+ضدها الرخاوة و بينهم التوسط التوسط ما هو التوسط؟
+
+22
+00:01:57,940 --> 00:02:02,040
+اعتدال الصوت في المخرج عند النطق بحرف التوسط لعدم
+
+23
+00:02:02,040 --> 00:02:07,260
+كمال انحباس فيه ما هي حروف التوسط؟ مجموعة في قوله
+
+24
+00:02:07,260 --> 00:02:12,360
+لين عمرو الصفة المضادة للشدة هي صفة الرخوة وهي
+
+25
+00:02:12,360 --> 00:02:17,560
+جريان الصوت في المخرج عند النطق بحرف الرخوة لضعف
+
+26
+00:02:17,560 --> 00:02:22,890
+اعتماد الحرف على مخرجه ما هي حروف الرخوة؟باقي حروف
+
+27
+00:02:22,890 --> 00:02:26,790
+اللغة العربية باقي حروف اللغة العربية أو ممكن نقل
+
+28
+00:02:26,790 --> 00:02:30,590
+حروف اللغة العربية نستثنى منها حروف الشدة اللي هي
+
+29
+00:02:30,590 --> 00:02:35,870
+أجد قطبكت و حروف التوسط اللي هي لنعمر صفة الشدة
+
+30
+00:02:35,870 --> 00:02:42,380
+صفة إيه؟ قوة الرقابة؟ بعض صفة التوسط؟معتدلا، مش
+
+31
+00:02:42,380 --> 00:02:46,740
+محسوبا، لا هي مع القوة ولا مع الاضعاف ننتقل إلى
+
+32
+00:02:46,740 --> 00:02:51,100
+الصفة الثالثة المتضادة اللي هي صفة الاستعلاء و
+
+33
+00:02:51,100 --> 00:02:56,900
+ضدها الاستفاد ما معنى الاستعلاء ارتفاع أقصى اللسان
+
+34
+00:02:56,900 --> 00:03:01,700
+إلى الحنك الأعلى عند النطق بحرف الاستعلاء ما هي
+
+35
+00:03:01,700 --> 00:03:07,530
+حروف الاستعلاء؟مجموعة في قوله خصة ضغط انقدر الصفة
+
+36
+00:03:07,530 --> 00:03:12,750
+المضادة للاستعلاق هي صفة الاستفال وهي انخفاض
+
+37
+00:03:12,750 --> 00:03:17,410
+اللسان إلى قاع الفمي عند النطمئ بحرف الاستفال ما
+
+38
+00:03:17,410 --> 00:03:21,940
+هي حروف الاستفال؟باقي حروف اللغة العربية ونحن نرى
+
+39
+00:03:21,940 --> 00:03:26,680
+هنا أن الصفات المتضادة تتنازع حروف اللغة العربية
+
+40
+00:03:26,680 --> 00:03:30,720
+يعني لا يمكن أن يكون هناك في الحرف الواحد صفة
+
+41
+00:03:30,720 --> 00:03:35,740
+الاستعلاء وصفة الاستفال أو صفة الشدة وصفة الرخاوة
+
+42
+00:03:35,740 --> 00:03:41,460
+أو صفة الهمس وصفة الجهر إنما هي تتنازع ما بين كل
+
+43
+00:03:41,460 --> 00:03:45,780
+صفة متضادة تتنازع حروف اللغة العربية وهناك صفات
+
+44
+00:03:45,780 --> 00:03:51,310
+قوية وهناك صفات ضعيفةننتقل إلى صفة الرابعة و هي
+
+45
+00:03:51,310 --> 00:03:55,590
+صفة الإطباق و ضدها الانفتاح ما معنى الإطباق يا
+
+46
+00:03:55,590 --> 00:04:00,610
+أخوات؟ الإلتصاق لغة أو التصاق طائف من اللسان
+
+47
+00:04:00,610 --> 00:04:05,370
+بالحלק الأعلى عند النطق بحرف الإطباق ما هي حروف
+
+48
+00:04:05,370 --> 00:04:15,210
+الإطباق؟ أربعة حروف الأط ط و الض و الصادوضال يعني
+
+49
+00:04:15,210 --> 00:04:19,830
+صاب ضاطة ض اربع حروف هذه الحروف الأربعة لأنها
+
+50
+00:04:19,830 --> 00:04:24,570
+تلتسق بالحنك الأعلى عند النطق بحرف الإطباق نسميها
+
+51
+00:04:24,570 --> 00:04:27,810
+اللي هي صفة إطباق وصفة الإطباق صفة إيه يا أخوات
+
+52
+00:04:27,810 --> 00:04:32,840
+قوة ولا ضعف؟قوة و ضدها الانفتاح و معنى الانفتاح
+
+53
+00:04:32,840 --> 00:04:36,120
+اللي هو الافتراك افتراك اللسان عن الحناك الأعلى
+
+54
+00:04:36,120 --> 00:04:39,960
+إلى قاع الفمي او افتراك اللسان عن الحناك الأعلى
+
+55
+00:04:39,960 --> 00:04:44,780
+عند النطق بحرف ال ايه؟ بحرف ال .. الانفتاح بينفتح
+
+56
+00:04:44,780 --> 00:04:50,120
+و حروفه باقي حروف اللغة العربية و هو صفة ضعف ولا
+
+57
+00:04:50,120 --> 00:04:56,340
+قوة؟ ضعف اخر صفتين اللي هي صفة الإذلاق و صفة
+
+58
+00:04:56,340 --> 00:05:02,910
+الاصمات عكسه او ضدهممن يعرف لنا الإذلاق .. خفة
+
+59
+00:05:02,910 --> 00:05:06,050
+الحرف و سرعة النطق به .. أه يعني خفة الحرف و سرعة
+
+60
+00:05:06,050 --> 00:05:10,410
+النطق به لخروجه من طرف اللساني أو الشفة أو الشفتين
+
+61
+00:05:10,410 --> 00:05:15,110
+معاه بمعنى أنه يخرج بسهولة و يسر و خفة من طرف
+
+62
+00:05:15,110 --> 00:05:20,190
+اللساني أو الشفة أو الشفتين معاه وحروف الإذلاق ما
+
+63
+00:05:20,190 --> 00:05:28,280
+هي؟ستة مجموعة في قوله فر من لبن الف و الر و م و ن
+
+64
+00:05:28,280 --> 00:05:33,840
+و ر و ب فر من لبن تلت حروف بتخرج من طرف اللسان
+
+65
+00:05:33,840 --> 00:05:39,300
+نحنا نقولاللي يخرج من طرف اللسان أو الشفة أو
+
+66
+00:05:39,300 --> 00:05:42,880
+الشفتين معاها الحروف اللتي تخرج من طرف اللسان اللي
+
+67
+00:05:42,880 --> 00:05:48,180
+هي النون واللام والرا اللي هي فرة من لبن النون
+
+68
+00:05:48,180 --> 00:05:53,620
+واللام والرا والحرف اللي يخرج من شفة الواحدة اللي
+
+69
+00:05:53,620 --> 00:05:59,830
+هو حرف ال Fالف والحرف .. الحرفين الذين يخرجان من
+
+70
+00:05:59,830 --> 00:06:04,070
+الشفتين معاهم الـ mean و الـ ba إذا حروف الإذلاق
+
+71
+00:06:04,070 --> 00:06:09,450
+فر من لبّهم الصفة المضادة للإذلاق هي صفة الإصمات
+
+72
+00:06:09,450 --> 00:06:12,990
+أو الإصمات ما هو معنوها؟ معناته المنع .. منع
+
+73
+00:06:12,990 --> 00:06:17,810
+انفراد حروف الإصمات في أصول الكلمات الربعية أو
+
+74
+00:06:17,810 --> 00:06:22,610
+الخمسية يعني يمنع أن تنفرد حروف الإصمات كلها في
+
+75
+00:06:22,610 --> 00:06:24,930
+أصول الكلمات الربعية أو الخمسية يعني الكلمة
+
+76
+00:06:24,930 --> 00:06:29,020
+الربعيةأو الخماسية لا يصح لها في اللغة العربية أن
+
+77
+00:06:29,020 --> 00:06:34,360
+تكون كل حروفها من حروف الإصمات يعني لابد أن تكون
+
+78
+00:06:34,360 --> 00:06:38,740
+فيها أقل شئ حرف من حروف الإذلاق اللي هو فرة من لبن
+
+79
+00:06:39,850 --> 00:06:44,730
+فإذا وجدت كلمة جميع حروفها حروف إصمات، ما معنى
+
+80
+00:06:44,730 --> 00:06:49,530
+هذا؟ أن هذه الكلمة ليست عربية، بل هي إيش يا أخوات؟
+
+81
+00:06:49,530 --> 00:06:53,850
+معربة، يعني كانت فارسية ودخلت اللغة العربية، كانت
+
+82
+00:06:53,850 --> 00:06:58,650
+يونانية ودخلت اللغة العربية، يعني صارت معربة، من
+
+83
+00:06:58,650 --> 00:07:02,970
+يذكر لنا بعض الكلمات أو كلمة من الكلمات اللي
+
+84
+00:07:02,970 --> 00:07:07,620
+عُرّبت فصارت كأنها عربية، تفضل أختككلمة أستاذ
+
+85
+00:07:07,620 --> 00:07:12,320
+عارفين أنه أحنا كلمة أستاذ يعني جميع حروفها حروف
+
+86
+00:07:12,320 --> 00:07:17,860
+أصمات لأنه ليس لها جذر لا نقول أستاذ يؤستذ أستاذة
+
+87
+00:07:17,860 --> 00:07:22,120
+فهو مؤستذ مافيش فعلها فعل إنما هي كلمة جامدة
+
+88
+00:07:22,120 --> 00:07:26,700
+جاءتنا من الفارسية أنها أستاذ يبقى هي بمعنى أستاذ
+
+89
+00:07:26,700 --> 00:07:31,330
+عندنا كلمة مؤلم الأستاذ بمعنى المعلموالمعلم علم
+
+90
+00:07:31,330 --> 00:07:37,290
+يعلمه تعليما فهو معلم وعليم وعلمان يعني إلها جذور
+
+91
+00:07:37,290 --> 00:07:41,950
+لكن كلمة أستاذ مالها إش جذور كلمة أستاذ جامدة زي
+
+92
+00:07:41,950 --> 00:07:50,230
+كلمة مثلا computer، bus مثلا computer، bus،
+
+93
+00:07:50,230 --> 00:07:53,690
+bicycle مثلا هذه الكلمات كلها أصبحت داخلة علينا
+
+94
+00:07:53,690 --> 00:07:58,890
+يعني لا نقول مثلاعن كلمة الكمبيوتر هي عربية لان
+
+95
+00:07:58,890 --> 00:08:05,310
+اقول عنها كمبترة مابتجيش اصلا لان هي جامدة جات
+
+96
+00:08:05,310 --> 00:08:08,270
+بهذا الشكل من اللغات الثانية او من اللغة
+
+97
+00:08:08,270 --> 00:08:12,470
+الانجليزية لذا ليست عربية لكنها اصبحت معربة يعني
+
+98
+00:08:12,470 --> 00:08:17,210
+اذا اراد اي واحد مننا يذهب الىالمحل الحاسوب يعني
+
+99
+00:08:17,210 --> 00:08:20,510
+يقول بدي كمبيوتر اريد كمبيوتر مثلا او بكم هذا
+
+100
+00:08:20,510 --> 00:08:23,910
+الكمبيوتر مثلا انما لا يقول .. حتى كلمة الحاسوب مع
+
+101
+00:08:23,910 --> 00:08:27,910
+أنها عُربت صارت حاسوب يعني قليل من الناس من يقول
+
+102
+00:08:27,910 --> 00:08:31,990
+عنه انه ايه انه حاسوب تعرف .. تعرف الناس عليه ان
+
+103
+00:08:31,990 --> 00:08:38,330
+يقول حاسوب او راديو او تلفزيون او مثلا boss و هكذا
+
+104
+00:08:38,330 --> 00:08:43,210
+من هذه الأمور الكلمات التي عُربت فكلمة أستاذيعني
+
+105
+00:08:43,210 --> 00:08:46,550
+على مدار التاريخ دخلت اللغة العربية و هي ليست
+
+106
+00:08:46,550 --> 00:08:50,870
+عربية و صارت معربة يعني يتعامل معها الناس على أساس
+
+107
+00:08:50,870 --> 00:08:54,970
+أنها كلمة عربية و هي في الأساس ليست عربية كذلك
+
+108
+00:08:54,970 --> 00:09:03,870
+كلمة عسجد عسجد يعني كجميع حروفها إيه مصممة يعني
+
+109
+00:09:03,870 --> 00:09:07,130
+مافيش فيها حرف من حروف الإذلاق إذا هي ليست عربية
+
+110
+00:09:07,130 --> 00:09:13,210
+مامعنى عسجد عسجد يعني الذهبعسيد بمعناته الذهب،
+
+111
+00:09:13,210 --> 00:09:17,030
+عندنا .. نحن في بلادنا بنستخدم كلمة ذهب، لكن هناك
+
+112
+00:09:17,030 --> 00:09:22,530
+بعض الناس .. الدول ممكن يسمونه العسيد لأنها من لغة
+
+113
+00:09:22,530 --> 00:09:26,910
+ثانية جاءت إلينا، هذه حروف الإصمات، لكن يا أخوات
+
+114
+00:09:26,910 --> 00:09:32,950
+الإصمات والإذلة كلاهما صفة قوة ولا ضعف ولا معتدلة؟
+
+115
+00:09:33,630 --> 00:09:37,550
+كلاهما متوسطة إذا ما هي الحروف المتوسطة عندنا من
+
+116
+00:09:37,550 --> 00:09:42,190
+الصفات التي أخذناها ما هي الصفات المتوسطة التوسط
+
+117
+00:09:42,190 --> 00:09:47,150
+هي واحد الإذلاق والإصمات كلها صفات توسط ما هي صفات
+
+118
+00:09:47,150 --> 00:09:52,250
+القوة التي أخذناها الشدة والجهر والاستعلاء
+
+119
+00:09:52,250 --> 00:09:57,150
+والاطباق بس هذه الصفات الأربع هل يمكن أن يكون في
+
+120
+00:09:57,150 --> 00:10:01,030
+الحرف الواحد أكثر من صفة يعني ممكن الحرف الواحد
+
+121
+00:10:01,030 --> 00:10:06,140
+يكون فيه تلت أربع خمس ست صفاتأقل شيء يا أخوات لابد
+
+122
+00:10:06,140 --> 00:10:09,080
+أن يوجد في الحرف الواحد خمس صفات اللي هي الخمس
+
+123
+00:10:09,080 --> 00:10:12,580
+صفات المتضادة اللتي تتنازح حروف اللغة العربية
+
+124
+00:10:12,580 --> 00:10:17,820
+وممكن أن تزيد توصل ست صفات أو سبع صفات من الصفات
+
+125
+00:10:17,820 --> 00:10:21,840
+اللتي ليس لها ضد و اللتي سوف ناخدها الآن ان شاء
+
+126
+00:10:21,840 --> 00:10:27,040
+الله أخدنا الصفات المتضادةكل صفة و ضدها منها
+
+127
+00:10:27,040 --> 00:10:30,880
+القوية و منها الضعيفة و منها المعتدلة المتوسطة
+
+128
+00:10:30,880 --> 00:10:35,560
+يعني و هناخد الآن الصفات اللتي ليس لها ضد و هي
+
+129
+00:10:35,560 --> 00:10:40,060
+يعني تسع صفات اللي هي الصفير و القلقلة و الانحراف
+
+130
+00:10:40,060 --> 00:10:45,520
+و التكرير و اللين و الخفاء و الغنى و الاستطالة تسع
+
+131
+00:10:45,520 --> 00:10:49,240
+صفات الصفة الأولى اللي سوف ناخدها هي صفة الاش
+
+132
+00:10:49,240 --> 00:10:55,250
+أخواتصفة الصفير معنى الصفير الصوت الحاد يخرج صوتا
+
+133
+00:10:55,250 --> 00:10:59,670
+حادا سواء كان يعني إنسان ب .. ب .. ب .. ب ..
+
+134
+00:10:59,670 --> 00:11:03,710
+بلسانه يخرج هذا الصوت أو الصوت الحاد الذي يخرج من
+
+135
+00:11:03,710 --> 00:11:08,310
+الثقب أحيانا بعض النوافذ بيكون فيه رياح في الخارج
+
+136
+00:11:08,310 --> 00:11:12,550
+نسمع الصفير بيخرج من بين الظلفتين يسمى هذه صفير
+
+137
+00:11:12,550 --> 00:11:17,820
+إذا الصفير من حيث اللغة هو الصوتالحاد وهو كصوت
+
+138
+00:11:17,820 --> 00:11:21,700
+خارج من الثقب عند ضغط الهواء فيه يعني حتى لو جينا
+
+139
+00:11:21,700 --> 00:11:28,600
+ببوصة فاتحنا منها جزء بصورة معينة وضغطنا فيها
+
+140
+00:11:28,600 --> 00:11:34,000
+الهواء بتخرج بخ الصفير أو الزامرة أو صوت حاد يسمى
+
+141
+00:11:34,000 --> 00:11:38,900
+الصفير هذا من حيث اللغة اما من حيث الاصطلاح من
+
+142
+00:11:38,900 --> 00:11:44,300
+يعرف لنا الصفير من حيث الاصطلاح هو إيش انحصار
+
+143
+00:11:45,490 --> 00:11:49,930
+انحصار الصوت بين طرف اللسان وفوايق الثانية يعني
+
+144
+00:11:49,930 --> 00:11:54,150
+انحصار الصوت في المخرج الصوت ينحصر في مخرج حروف
+
+145
+00:11:54,150 --> 00:12:00,490
+معينة ما بين طرف اللسان وهذا واطراف الثانية العليا
+
+146
+00:12:00,490 --> 00:12:05,090
+والسفلة بينحصر الصوت فبيخرج الصوت من هذا المكان
+
+147
+00:12:05,090 --> 00:12:09,450
+الضيق يعني بهذا الشكل يعني الطراف الثانية العليا
+
+148
+00:12:09,450 --> 00:12:14,600
+والسفلةبتكون مع بعضها البعض واللسان ينسابه من
+
+149
+00:12:14,600 --> 00:12:19,920
+الداخل بحيث يسمح للصوتي بالانسياب من بين الفتحة
+
+150
+00:12:19,920 --> 00:12:23,220
+الضيقة ما بين أطراف الثانية العليا والسفلة يعني
+
+151
+00:12:23,220 --> 00:12:24,640
+اللي أقول ه .. أس
+
+152
+00:12:28,660 --> 00:12:34,240
+الان أطراف الثانية العليا والسفلة ملتصقات
+
+153
+00:12:34,240 --> 00:12:38,440
+في بعض في هناك فتحة ضيقة ما بين أطراف الثانية
+
+154
+00:12:38,440 --> 00:12:42,820
+العليا والسفلة بينحصل الصوت ما بين طرف اللسان
+
+155
+00:12:42,820 --> 00:12:47,500
+وفوايق الثانية فتخرج منه حروف الصفير فما هي حروف
+
+156
+00:12:47,500 --> 00:12:53,360
+الصفير يا أخوات الصاد والسين والزايد الصاد والسين
+
+157
+00:12:53,360 --> 00:13:02,370
+والزايد يعني أس أسمناجد انه ينحصر الصوت ما بين طرف
+
+158
+00:13:02,370 --> 00:13:07,950
+اللسان وفوايق الثانية هذه الصفة الصفية وصفة الصفية
+
+159
+00:13:07,950 --> 00:13:14,720
+طبعا كما يقول الصين تشبه صوت سرب الجرادالجراد طبعا
+
+160
+00:13:14,720 --> 00:13:20,060
+يلاقوا عندما يكونوا سربا بيخرجوا صوتا يشبهوا صوت
+
+161
+00:13:20,060 --> 00:13:28,060
+الحرف ال s يعني ال s يشبه صوت سرب الجراد ال z يشبه
+
+162
+00:13:28,060 --> 00:13:32,720
+صوت النحل عندما يكون في نحل او سرب نحل يسير في
+
+163
+00:13:32,720 --> 00:13:38,260
+الهواء بنسمعهذه حرف ازاي والصاد بيشبه صوت ال ايه
+
+164
+00:13:38,260 --> 00:13:43,200
+ال oars طبعا تثبت يا أخوات هذه الصفة اللي هي صفة
+
+165
+00:13:43,200 --> 00:13:48,580
+الصفير في جميع أحوال الحروف سواء كانت ساكنة يعني
+
+166
+00:13:48,580 --> 00:13:53,520
+حرف الصين والصاد وازاي تشبه يعني تثبت صفة الصفير
+
+167
+00:13:53,520 --> 00:14:01,150
+له في جميع أحوالهممكن يكون ساكن الصالحين السائلين
+
+168
+00:14:01,150 --> 00:14:08,130
+مثلا بيكون ساكن او متحرك سأل سائل صالح حرف متحرك
+
+169
+00:14:08,130 --> 00:14:12,350
+او في واصل الكلمة او في اخر الكلمة يبقى في جميع
+
+170
+00:14:12,350 --> 00:14:18,310
+احوال الحرفحافستين والصال وازاي سواء كان ساكنا او
+
+171
+00:14:18,310 --> 00:14:25,270
+متحركا متوسطا او متطرفا ابتثبت فيه صفة الصفير ولكن
+
+172
+00:14:25,270 --> 00:14:30,510
+بتكون اقوى عندما يكونوا ساكنا او ساكنا مشددا مثال
+
+173
+00:14:30,510 --> 00:14:38,450
+ذلككلمة الصالحين الصالحين حرف الصاد يعني مشدد
+
+174
+00:14:38,450 --> 00:14:42,970
+نتيجة الإضغام ما بين اللام والصاد اللام المضغمة
+
+175
+00:14:42,970 --> 00:14:49,430
+نقول الصالحين فالصاد تثبت فيه صفة الصفير كذلك كلمة
+
+176
+00:14:49,430 --> 00:14:54,990
+ثانية واصبر صبرا جميلة واصبر حرف الصاد في واصبر
+
+177
+00:14:54,990 --> 00:15:00,450
+أيضا في صفة الصفير الساعة الساعة ايش كمان في
+
+178
+00:15:00,450 --> 00:15:08,110
+كلمات؟فاستمع و الزاجرات زجرة فإذا حرف الصين والصاد
+
+179
+00:15:08,110 --> 00:15:13,890
+و إزاي هي حروف الصفير تخرج صوتا حادا عند نطقه تثبت
+
+180
+00:15:13,890 --> 00:15:18,850
+صفة الصفير في جميع أحوالها طيب الآن يا أخوات صفة
+
+181
+00:15:18,850 --> 00:15:24,270
+الصفير هل هي صفة قوة ولا صفة ضعف؟صفة الصفير صفة
+
+182
+00:15:24,270 --> 00:15:28,150
+قوة الصوت الحاد حتى يعني إذا أراد إنسان أن ينبه
+
+183
+00:15:28,150 --> 00:15:34,670
+إنسان بيقول اس أو از فهذا الصوت الحاد بيسمع لذلك
+
+184
+00:15:34,670 --> 00:15:39,590
+صفة الصفير هي صفة قوة ننتقل يا أخوات إلى الصفة
+
+185
+00:15:39,590 --> 00:15:44,710
+الثانية التي يعني ليس لها ضد لو قلنا صحيح صفة
+
+186
+00:15:44,710 --> 00:15:49,930
+الصفير ما هو ضدهاليس لها ضد .. ليس مثل الصفات
+
+187
+00:15:49,930 --> 00:15:54,570
+الماضية اللي هي الهمس والجهر والشدة ضدها رفاوة
+
+188
+00:15:54,570 --> 00:15:58,830
+التوسط الاستعلاء ضده الاستفال وهاكذا انما هذه صفة
+
+189
+00:15:58,830 --> 00:16:03,270
+لوحدها ولها حروف محددة مطلوب مننا ان نعرف صفة
+
+190
+00:16:03,270 --> 00:16:08,670
+الصفير وكيف ننطقه بالصفير او نخرجه من مكانه وما هي
+
+191
+00:16:08,670 --> 00:16:13,440
+حروفه الصفة الثانية يا اخوات هي صفة الايهالقلقلة
+
+192
+00:16:13,440 --> 00:16:19,200
+صفة ليس لها ضد إنما هي صفة القلقلة والقلقلة من
+
+193
+00:16:19,200 --> 00:16:24,080
+الاضطراب والتحريك يعني نقول تقلقل الشيء بمعنى
+
+194
+00:16:24,080 --> 00:16:28,580
+اضطربة واتحرك يوجد قلاقل في البلد الفلانية يعني
+
+195
+00:16:28,580 --> 00:16:33,240
+اضطرابات ومشاكل في البلد الفلانية هذا من حيث اللغة
+
+196
+00:16:33,240 --> 00:16:36,980
+أما من حيث الاصطلاح ما معنى القلقلة يا أخوات
+
+197
+00:16:36,980 --> 00:16:39,200
+اصطلاحا فضلي
+
+198
+00:16:43,840 --> 00:16:48,440
+أحسنت اضطراب المخرج عند النطق بحرف القلقلة حتى
+
+199
+00:16:48,440 --> 00:16:55,720
+يسمع له نبرة قوية المخرج يضطرب عندما نقول مثلا أب
+
+200
+00:16:55,720 --> 00:17:02,900
+في اضطراب وانحصار للصوت و للنفس فيضغط المخرج يغلق
+
+201
+00:17:02,900 --> 00:17:07,140
+ثم بعد ذلك ينفتح المخرج فتخرج منه النبرة التي
+
+202
+00:17:07,140 --> 00:17:11,770
+نسميها نحن الأيهالقلقلة إذا تعريف القلقلة هو
+
+203
+00:17:11,770 --> 00:17:17,010
+اضطراب المخرج عند النطق بأحد حروف القلقلة حتى يسمع
+
+204
+00:17:17,010 --> 00:17:23,490
+له نبرة قوية فما هي حروف القلقلة يا أخوات مجموعة
+
+205
+00:17:23,490 --> 00:17:28,930
+في قوله خطوب جن هي خمس حروف عندما أقول مثلا أنا
+
+206
+00:17:28,930 --> 00:17:35,860
+أقق أقق فيها قلقلة ولا لا هذه القلقلة أققأو الحق
+
+207
+00:17:35,860 --> 00:17:41,940
+أو قل أعوذ برب الفلق فهذه الأقق تسمى إيش؟ تسمى
+
+208
+00:17:41,940 --> 00:17:48,600
+قلقلة وهو ناتج عن انحباس صفتي الصوت والنفس يعني
+
+209
+00:17:48,600 --> 00:17:52,200
+اجتماع الصفتي الشدة والجهر الشدة انحباس الصوت
+
+210
+00:17:52,200 --> 00:17:57,620
+والجهر انحباس النفس في حروف القلقلة فلمّا يحبس
+
+211
+00:17:57,620 --> 00:18:04,180
+النفس ويحبس الصوتثم بعد ذلك يفتح المخرج فتخرج منه
+
+212
+00:18:04,180 --> 00:18:11,120
+النبرة يعني عندما أقول مثلا أنا اغلق
+
+213
+00:18:11,120 --> 00:18:16,840
+المخرج وانحبس النفس وانحبس الصور ثم يفتح المخرج
+
+214
+00:18:16,840 --> 00:18:23,640
+فتخرج منه النبرة التي نسميها نحن القلقلة كذلك حرف
+
+215
+00:18:23,640 --> 00:18:33,910
+الأق أو إب إج إدكل هذه تسمى إيه؟ تسمى حروف قلقلة،
+
+216
+00:18:33,910 --> 00:18:37,850
+لو سألنا يعني ما هي سر القلقلة؟
+
+217
+00:18:40,510 --> 00:18:44,270
+أحسنتي اجتماع صفتي الشدة والجهر الشدة فيها إيش يا
+
+218
+00:18:44,270 --> 00:18:48,750
+أخوات انحباس الصوت والجهر انحباس النفس لما انحبسش
+
+219
+00:18:48,750 --> 00:18:55,170
+الصوت والنفس بعد ذلك يخرج أو يفتح المخرج فتخرج منه
+
+220
+00:18:55,170 --> 00:19:00,490
+النبرة وكما قلنا سابقا بتثبت القلقلة في جميع أحوال
+
+221
+00:19:00,490 --> 00:19:05,290
+حروف القلقلة ولكن بيكون أثبت يعني عندما كنت ساكنأو
+
+222
+00:19:05,290 --> 00:19:12,230
+متحرك مثلا عندما يكون في وسط الكلمة أو في آخر
+
+223
+00:19:12,230 --> 00:19:17,430
+الكلمة لكن بيكون ثابت وواضح جدا عندما يكون ساكن أو
+
+224
+00:19:17,430 --> 00:19:22,780
+مشدد وعندما يكون متحركبتكون في أصل القلقلة يعني
+
+225
+00:19:22,780 --> 00:19:27,080
+عندما نقول قال في أصل القلقلة لكن غير عن الحق
+
+226
+00:19:27,080 --> 00:19:31,800
+القلقلة واضحة وكبيرة أما بالنسبة لأقسام القلقلة يا
+
+227
+00:19:31,800 --> 00:19:36,060
+أخوات تنقسم القلقلة إلى عدة أقسام ما هي أقسام
+
+228
+00:19:36,060 --> 00:19:44,020
+القلقلة أمي عارفة تفضل أختكإذا في عندنا ثلاث أقسام
+
+229
+00:19:44,020 --> 00:19:50,420
+قلقلة صغيرة و قلقلة كبرى و قلقلة أكبر أما القلقلة
+
+230
+00:19:50,420 --> 00:19:55,720
+الصغيرة فهو إذا جاء أحد حروف القلقلة ساكنا متوسطا
+
+231
+00:19:55,720 --> 00:20:00,420
+في الكلمة تكون قلقلة صغيرة من ياتي بأمثلة على
+
+232
+00:20:00,420 --> 00:20:05,420
+القلقلة الصغيرة فضل أختيسبحان .. سبحان فيها ..
+
+233
+00:20:05,420 --> 00:20:10,420
+فيها قلقلة لكن ليست مثل تبت يد أبي لهبي و تب .. بأ
+
+234
+00:20:10,420 --> 00:20:16,680
+لأن عندما أقول اب بأ قوية لكن سبحان فيها قلقلة لكن
+
+235
+00:20:16,680 --> 00:20:20,200
+أصلا .. يعني قليلة سبحان الذي أسرى بعبده ليلا
+
+236
+00:20:20,200 --> 00:20:24,760
+سبحان فيها قلقلة ولكنها بتكون صغيرة لأنها جاءت
+
+237
+00:20:24,760 --> 00:20:29,060
+الحرف القلقلة اللي هو ال با في وسط الكلمة كذلك
+
+238
+00:20:29,060 --> 00:20:31,380
+كلمة مقتدرا
+
+239
+00:20:33,050 --> 00:20:37,330
+مقتدرة فيها قلقلة ولكن القلقلة بتكون إيش يا أخوات
+
+240
+00:20:37,330 --> 00:20:42,830
+القلقلة صغرة لأن حرف القلقلة جاء متوسطا هنا
+
+241
+00:20:42,830 --> 00:20:50,310
+المجرمون حرف الإج حرف الإج في قلقلة صغرة لأنه جاء
+
+242
+00:20:50,310 --> 00:20:55,840
+متوسطا كذلك من يقرأ هذه الكلمة فضليقد أفلح
+
+243
+00:20:55,840 --> 00:20:59,640
+المؤمنون طبعا قد أفلح المؤمنون قد جاءت في أخر
+
+244
+00:20:59,640 --> 00:21:03,580
+الكلمة صح لكنها في حالة الواصل بتكونش أخر الكلمة
+
+245
+00:21:03,580 --> 00:21:07,760
+قد أفلح المؤمنون يعني قد أفلح المؤمنون في عندنا
+
+246
+00:21:07,760 --> 00:21:11,640
+قلقلة صغيرة في حالة الواصل لكن لو وقفنا عليها من
+
+247
+00:21:11,640 --> 00:21:15,480
+باب الاختبار أو الإضطرار واحد وقف مثلا من باب
+
+248
+00:21:15,480 --> 00:21:21,300
+اضطرارا او اختبارا قال قدلكن مانفعش نقول قدق،
+
+249
+00:21:21,300 --> 00:21:24,240
+بعدين نقول أفلح المؤمنون، لأنه هذا .. يعني
+
+250
+00:21:24,240 --> 00:21:28,260
+الابتداء قبيح والوقف قبيح، لذلك لابد أن نرجع، لكن
+
+251
+00:21:28,260 --> 00:21:34,280
+من باب الاختبار، يعني لو قال المدرس للطالب أسكت أو
+
+252
+00:21:34,280 --> 00:21:38,660
+قف عند كلمة قدق، هيبين أنه عندنا .. عندنا هتكون
+
+253
+00:21:38,660 --> 00:21:44,430
+القلقلة كبرىلكن قد أفلحة تكون القلقلة صغيرة وهذا
+
+254
+00:21:44,430 --> 00:21:48,390
+يا أخوات يعني عادة ما يأتي بالامتحان يعني بيقولك
+
+255
+00:21:48,390 --> 00:21:56,710
+أن حرف الدال في قد حالة الوصل قلقلة كبرى صح ولا
+
+256
+00:21:56,710 --> 00:22:00,670
+غلط؟ بيكون طبعا هي غلط وإنما هو قلقلة صغيرة في
+
+257
+00:22:00,670 --> 00:22:04,930
+الوصل لكن لو وقفنا عليه اضطرارا او اختبارا بيكون
+
+258
+00:22:04,930 --> 00:22:07,430
+قلقلة كبرى
+
+259
+00:22:08,730 --> 00:22:12,590
+القلقلة الثانية أو النوع الثاني القسم الثاني ما هو
+
+260
+00:22:12,590 --> 00:22:15,390
+يا أخوات؟ اللي هي القلقلة الكبرى، أخدنا القلقلة
+
+261
+00:22:15,390 --> 00:22:19,850
+الصغيرة، القسم الثاني قلقلة كبرى، من يعرف لها
+
+262
+00:22:19,850 --> 00:22:23,870
+القلقلة الكبرى؟ يعني إذا جاء .. فضلي
+
+263
+00:22:27,470 --> 00:22:32,550
+إلى جاء أحد حروف القلقلة ساكنا مخففا موقوفا عليه
+
+264
+00:22:32,550 --> 00:22:38,810
+يسمى قلقلة كبرى لابد أن يكون ساكن وموقوف والسكون
+
+265
+00:22:38,810 --> 00:22:43,970
+كذلك مخفف في عنده مخفف وفي عنده مثقل المثقل هو
+
+266
+00:22:43,970 --> 00:22:48,090
+المشدد لأن المشدد هو عبارة عن حرفين مضغمات مع
+
+267
+00:22:48,090 --> 00:22:51,860
+بعضهم البعضيعني حرف ساكن و حرف متحرك اضغمو فصار
+
+268
+00:22:51,860 --> 00:22:58,380
+مشدد لكن عندما يكون فقط ساكن عليه سكون ووقفنا عليه
+
+269
+00:22:58,380 --> 00:23:04,560
+يسمى قلقلة كبرى ممكن يا أخوات يكون هو مضمومأو
+
+270
+00:23:04,560 --> 00:23:09,160
+مفتوح أو متحرك لكن عند الوقف عليه نسكن لأن العرب
+
+271
+00:23:09,160 --> 00:23:13,620
+كما نقول لا يبدأون الكلام بساكن ولا يقفون على
+
+272
+00:23:13,620 --> 00:23:17,820
+متحرك مثال ذلك قُلْ هُوَ اللَّهُ أحدٌ هي منونة
+
+273
+00:23:17,820 --> 00:23:21,520
+أحدٌ لو وقفنا عليه بسلطة قُلْ هُوَ اللَّهُ أحدٌ
+
+274
+00:23:21,520 --> 00:23:26,200
+قال .. قال إيه؟ قال كبرة لكن لو وصلناها قُلْ هُوَ
+
+275
+00:23:26,200 --> 00:23:30,180
+اللَّهُ أحدٌ اللَّهُ الصَّرَض فيها .. يعني نستمر
+
+276
+00:23:30,180 --> 00:23:35,490
+ونتيجة التقاء الساكن أحدٌالله الصمد نتخلص من
+
+277
+00:23:35,490 --> 00:23:40,670
+التقاء الساكنين بإيش بالكسر لكن هنا مثلا بتسمى
+
+278
+00:23:40,670 --> 00:23:46,460
+قلقلق كبرى قلقلق كبرى مثلا هو الأعوذ برب الفلقاءهي
+
+279
+00:23:46,460 --> 00:23:51,820
+أصلا برب الفلقي من شر ما خلق مكسورة لكن عند الوقف
+
+280
+00:23:51,820 --> 00:23:56,880
+عليه نقول قل أعوذ برب الفلق فيها القلقلة من شر ما
+
+281
+00:23:56,880 --> 00:24:03,020
+خلق فيها أيضا قلقلة والله بما يعملون محيط أيضا
+
+282
+00:24:03,020 --> 00:24:08,220
+كلمة محيط القلقلة مالها كبرى لأنه وقفنا على حرف
+
+283
+00:24:08,220 --> 00:24:13,640
+القلقلة ساكنا متطرفا يسمى قلقلة صغرة أيضا كلمة
+
+284
+00:24:13,640 --> 00:24:19,390
+هدمان يقراهاالغيب .. من يقرأ الغيب ويوضح القلقلة
+
+285
+00:24:19,390 --> 00:24:24,530
+.. اه تفضلي اخوان .. تفضلي .. الغيب .. الغيب ..
+
+286
+00:24:24,530 --> 00:24:28,210
+الغيب .. الغيب .. الغيب .. الغيب .. الغيب .. الغيب
+
+287
+00:24:28,210 --> 00:24:29,070
+الغيب .. الغيب .. الغيب .. الغيب .. الغيب .. الغيب
+
+288
+00:24:29,070 --> 00:24:29,170
+.. الغيب .. الغيب .. الغيب .. الغيب .. الغيب ..
+
+289
+00:24:29,170 --> 00:24:34,150
+الغيب .. الغيبأيوة البروج ما بنفع يا أخوان تقول
+
+290
+00:24:34,150 --> 00:24:55,110
+البروجششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششش
+
+291
+00:24:58,950 --> 00:25:05,610
+البروج .. البروج فيها قلقلة كبرى لأن حرف الجيم جاء
+
+292
+00:25:05,610 --> 00:25:11,310
+متطرفا فبيلتسق الوسط اللسان بالحنك الأعلى وبيمنع
+
+293
+00:25:11,310 --> 00:25:17,090
+النفس والصوت ثم بعد ذلك يفتح مخرج حرف الجيم فتخرج
+
+294
+00:25:17,090 --> 00:25:24,140
+النبرة فنقول البروج كذلك أحدكما قلنا قل هو الله
+
+295
+00:25:24,140 --> 00:25:30,740
+أحد أحد طبعا قلقلة كبرى في أي الحروف في الحرف الذي
+
+296
+00:25:30,740 --> 00:25:35,060
+وقفنا عليه إن هو حرف الدال أو حرف الجيم أو البا أو
+
+297
+00:25:35,060 --> 00:25:39,850
+الطا أو القافالقسم الثالث يا أخوات هو القلقل
+
+298
+00:25:39,850 --> 00:25:46,170
+الأكبر خدنا قلقل صغر قلقل كبر قلقل أكبر القلقل
+
+299
+00:25:46,170 --> 00:25:51,990
+الأكبر وهو إذا جاء أحد حروف القلقل ساكنا مشددا أو
+
+300
+00:25:51,990 --> 00:25:57,130
+مثقلا كلها مواحد مشددا أو مثقلا موقوف عليه بنسمي
+
+301
+00:25:57,130 --> 00:26:02,810
+قلقل أكبر لأنه اتشد يعني قوة لذلك عندنا الكثير من
+
+302
+00:26:02,810 --> 00:26:08,890
+الكلمات من ضمنها الحقفبدت تخرج القلقلة من كلمة
+
+303
+00:26:08,890 --> 00:26:15,170
+الحق قوية لإن القاف مالها؟ القاف مشددة الحق من
+
+304
+00:26:15,170 --> 00:26:19,050
+يقراها الحق مع بيان القلقلة اللي فيها؟ فضل أختي
+
+305
+00:26:19,050 --> 00:26:26,570
+الحق من يعيد الكلمة هذه؟ فضل أختي الحق لازم نبينها
+
+306
+00:26:26,570 --> 00:26:34,710
+يعني ممكن بعض الأخوات تخفيها تقول الحقبصوت خافت
+
+307
+00:26:34,710 --> 00:26:39,730
+فلا تخرجيها طبعا بتكون لابد أن تظهرها فتقول الحق
+
+308
+00:26:39,730 --> 00:26:47,530
+لأن فيها قلقل أكبر تبت يد أبي لهبي وتب و تب فيها
+
+309
+00:26:47,530 --> 00:26:55,110
+أيه؟ قلقل من يقرأ هذه ال .. و تب؟ فضل أخت و تب طيب
+
+310
+00:26:55,110 --> 00:27:02,890
+الحج .. الحج من يقرأ الحج؟ فضل أختالحج .. طب نفع
+
+311
+00:27:02,890 --> 00:27:08,710
+نقول الحج .. الحج يعني النفس ماشي و هذا طبعا ليه
+
+312
+00:27:08,710 --> 00:27:15,550
+صح انما نقول الحج .. الحج طيب أشد .. إذا هذه أقسام
+
+313
+00:27:15,550 --> 00:27:20,390
+القلقلة في عندنا كذلك يا أخوات مراتب القلقلة مراتب
+
+314
+00:27:20,390 --> 00:27:24,070
+القلقلة يعني نعكسها أقوى مرتبة اللي هي القلقلة
+
+315
+00:27:24,070 --> 00:27:28,870
+الأكبرالمرتبة الثانية القلقلة الكبرى المرتبة
+
+316
+00:27:28,870 --> 00:27:32,430
+التالتة القلقلة الصغرة والمرتبة الرابعة اللي هي
+
+317
+00:27:32,430 --> 00:27:37,470
+أصل القلقلة الحرف المتحرك إذا ما هي مراتب القلقلة؟
+
+318
+00:27:37,470 --> 00:27:42,050
+كم مرتبة؟ أربع المرتبة الأولى إذا جاء أحد حروف
+
+319
+00:27:42,050 --> 00:27:48,510
+القلقلة ساكنا مثقلا متطرفا موقوفا عليه عند مثل أشد
+
+320
+00:27:48,510 --> 00:27:55,940
+و تبالحق هذه بتكون قلقلة أكبر
+
+321
+00:28:21,150 --> 00:28:25,170
+المرتبة التالتة هي القلقلة الصغيرة وهو إذا جاء أحد
+
+322
+00:28:25,170 --> 00:28:29,670
+حروف القلقلة ساكنا متوسطا في الكلمة يكون عندنا
+
+323
+00:28:29,670 --> 00:28:32,970
+القلقلة .. إيش؟ قلقلة .. مرتبة تالتة اللي هي
+
+324
+00:28:32,970 --> 00:28:36,030
+القلقلة الصغيرة ماني أتي بمثال على القلقلة الصغيرة
+
+325
+00:28:36,030 --> 00:28:38,370
+مقتدرة
+
+326
+00:28:39,360 --> 00:28:44,380
+مقتذرة فيها قلقلة صغيرة سبحان .. سبحان فيها قلقلة
+
+327
+00:28:44,380 --> 00:28:49,060
+صغيرة المجرمون .. المجرمون فيها قلقلة ولكن بتكون
+
+328
+00:28:49,060 --> 00:28:55,400
+قلقلة صغيرة من أي مرتبة هذه المجرمون مرتبة التالتة
+
+329
+00:28:55,400 --> 00:29:00,420
+قد أفلح المؤمنون برضه مرتبة التالتة لكن لو وقفنا
+
+330
+00:29:00,420 --> 00:29:05,000
+على كلمة قدبتكون المرتبة ايه؟ المرتبة الثانية اللي
+
+331
+00:29:05,000 --> 00:29:09,380
+هي الكبرة طب اخر مرتبة اللي هي المرتبة رقم اربعة
+
+332
+00:29:09,380 --> 00:29:16,020
+هي ده الحرف المتحرك باعتبار ان فيه أصل القلقلة مثل
+
+333
+00:29:16,020 --> 00:29:22,000
+طبعةطبعة .. إيش فيها طبعة؟ المتحركة حرف الطبعة
+
+334
+00:29:22,000 --> 00:29:27,440
+مفتوح فيها أصل القلقلة لكن ليس مثل يطبع .. يطبع
+
+335
+00:29:27,440 --> 00:29:31,440
+حرف الطبعة .. الطبعة ساكن يا قلقلة صغيرة أو محيط
+
+336
+00:29:31,440 --> 00:29:38,560
+قلقلة أكبر أو قلقلة كبرى أو مثلا الحق قلقلة أكبر
+
+337
+00:29:38,560 --> 00:29:43,920
+كذلك يقولوا .. يقولوا حرف القعف في أصل القلقلة من
+
+338
+00:29:43,920 --> 00:29:47,550
+أي مرتبة هذا يا أخوات؟من القلقلة .. من المرتبة
+
+339
+00:29:47,550 --> 00:29:52,590
+الرابعة بصير حرف البا في كلمة بصير في قلقلة أصل
+
+340
+00:29:52,590 --> 00:29:57,250
+القلقلة بيكون هو من المرتبة الرابعةأخر شي عندنا يا
+
+341
+00:29:57,250 --> 00:30:02,930
+أخوات اللي هي كيفية أداء القلقلة كيف نؤدي القلقلة
+
+342
+00:30:02,930 --> 00:30:07,390
+هل بتكون القلقلة مائلة إلى الفتح ولا مائلة إلى
+
+343
+00:30:07,390 --> 00:30:11,890
+حركة الحرف اللذي قبلها في عندنا رأيها الرأي الأول
+
+344
+00:30:11,890 --> 00:30:15,690
+يا أخوات أن القلقلة طبعا هو مختلف علماء فيها الرأي
+
+345
+00:30:15,690 --> 00:30:20,650
+الأول أن القلقلة تكون مائلة إلى الفتح دائما مثال
+
+346
+00:30:20,650 --> 00:30:28,320
+ذلك مثلا الحقمائلة إلى الفتحة محيط مائلة إلى
+
+347
+00:30:28,320 --> 00:30:33,220
+الفتحة أحد مائلة إلى الفتحة أحد .. مايقولش أحد ولا
+
+348
+00:30:33,220 --> 00:30:38,000
+أحد دي انما كلها مائلة إلى الفتحة لذلك و هذا الرأي
+
+349
+00:30:38,000 --> 00:30:43,320
+الذي يمينه ليه العلماء أن حركة أو القلقلة دائما
+
+350
+00:30:43,320 --> 00:30:47,620
+بتكون مائلة إلى الفتحةالقول الثاني أخذ به أيضا بعض
+
+351
+00:30:47,620 --> 00:30:51,560
+العلماء أنها تكون مائلة إلى حركة الحرف اللي قبلها
+
+352
+00:30:51,560 --> 00:30:55,720
+إذا كانت الحركة الحرف اللي قبلها مفتوحة بتكون
+
+353
+00:30:55,720 --> 00:31:01,500
+مائلة إلى الفتح مثال ذلك أقرب .. أقرب فحرف القهر
+
+354
+00:31:01,500 --> 00:31:06,080
+ساكن والهمزة قبله متحرك مفتوح فبكون مائلة إلى
+
+355
+00:31:06,080 --> 00:31:10,240
+الفتح هنا أقول أقها .. أقرب .. أقرب بتكون مائلة
+
+356
+00:31:10,240 --> 00:31:15,470
+إلى الفتحإذا كانوا مضموم يعني هو ساكن مسبوك بحرف
+
+357
+00:31:15,470 --> 00:31:21,790
+مضموم مثل سبحان سبحان فنقول سبق سبحان البا مائلة
+
+358
+00:31:21,790 --> 00:31:25,690
+أو حركة القلقلة مائلة إلى إيه؟ إلى الضم لأن حرف
+
+359
+00:31:25,690 --> 00:31:30,770
+البا اللي جاب الحرف الصين مضموم سبحانو أو يكون
+
+360
+00:31:30,770 --> 00:31:34,270
+مائل إلا كسر لو كان الحرف اللي قابلها مكسور مثال
+
+361
+00:31:34,270 --> 00:31:40,730
+ذلك اقرأ اقرأ فالحرف القاف ساكن و ما قبله اش ماله
+
+362
+00:31:40,730 --> 00:31:45,030
+مكسور فبتكون في عندنا مائل إلا كسر هدول يا أخوات
+
+363
+00:31:45,030 --> 00:31:50,050
+هو ال .. ال .. يعني الوضعين اللي فيه .. فيه أداء
+
+364
+00:31:50,050 --> 00:31:55,210
+القلقلة أخر شي عندنا صفة القلقلة هل هي صفة قوة ولا
+
+365
+00:31:55,210 --> 00:31:59,490
+صفة ضعفقوة صبرا، إذا في عندنا الحكمين اللي أخذناهم
+
+366
+00:31:59,490 --> 00:32:04,250
+اليوم اللي هي الصفير و هي صفة قوة و القلقلة هي صفة
+
+367
+00:32:04,250 --> 00:32:07,790
+ضعف ان شاء الله في المحاضرات القادمة نكمل الصفات
+
+368
+00:32:07,790 --> 00:32:11,910
+المتضادة و نكتفي بهذا القدر و ن .. و بارك الله
+
+369
+00:32:11,910 --> 00:32:15,010
+فيكم و جزاكم الله خير و السلام عليكم و رحمة الله و
+
+370
+00:32:15,010 --> 00:32:15,490
+بركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/rHV0Kj8bHwQ_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/rHV0Kj8bHwQ_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..3c99fde271049e5209faf3c01f3d5a970fe3618a
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/rHV0Kj8bHwQ_postprocess.srt
@@ -0,0 +1,1480 @@
+1
+00:00:00,000 --> 00:00:02,680
+موسيقى
+
+2
+00:00:11,980 --> 00:00:14,400
+السلام عليكم ورحمة الله وبركاته باسم الله الرحمن
+
+3
+00:00:14,400 --> 00:00:18,640
+الرحيم الحمد لله وصلاة والسلام على رسول الله وعلى
+
+4
+00:00:18,640 --> 00:00:23,520
+آله وصحبه وسلم استكمالا للموضوع السابق في المخارج
+
+5
+00:00:23,520 --> 00:00:28,240
+والصفات نتحدث اليوم عن الرأي رأي ابن الجزري وهو
+
+6
+00:00:28,240 --> 00:00:34,340
+الرأي الذي نتبناه نحنأن مخارج الحروف العامة خمسة
+
+7
+00:00:34,340 --> 00:00:40,320
+يتفرع عنها سبعة عشرة مخرجا فرعيا نتحدث اليوم عن
+
+8
+00:00:40,320 --> 00:00:44,820
+تفصيل هذه المخارج احنا قلنا ان المخارج الخامسة ما
+
+9
+00:00:44,820 --> 00:00:51,070
+هي يا أخوات المخرج الأولالجوف واللسان والحلق
+
+10
+00:00:51,070 --> 00:00:58,230
+اللسان الشفتان الخيشون بيخرج منها سبعة عشرة مخرجا
+
+11
+00:00:58,230 --> 00:01:04,200
+فرعيا مخرج واحد من الجوف وثلاثة خارج من الحلقو
+
+12
+00:01:04,200 --> 00:01:09,560
+عشرة مخارج من اللسان و مخرجان من الشفتين و مخرج من
+
+13
+00:01:09,560 --> 00:01:13,920
+الخشوم هذه هي المخارج السبعة عشرة مخرجان فرعيا
+
+14
+00:01:13,920 --> 00:01:20,000
+المخرج الأول هو الجوف و الجوف في اللغة الخلاء و في
+
+15
+00:01:20,000 --> 00:01:25,440
+الاصطلاح الخلاء الواقع في الفمي و الحلقيبقى الجوف
+
+16
+00:01:25,440 --> 00:01:29,920
+و الخلاء نعرفه أن الهواء يخرج من الرئتين على
+
+17
+00:01:29,920 --> 00:01:34,820
+القصبة الهوائية يحتك في الحنجرة بأحبال الصوتية في
+
+18
+00:01:34,820 --> 00:01:40,180
+الحنجرة تخرج الصوت و بعد ذلك يخرج إلى الحلق و إلى
+
+19
+00:01:40,180 --> 00:01:45,500
+الفم هذا الخلاء كله يسمى اللي هو الجوف فالجوف من
+
+20
+00:01:45,500 --> 00:01:50,820
+حيث الاصطلاح هو الخلاء الواقع في الفم و الحلقوله
+
+21
+00:01:50,820 --> 00:01:56,180
+حروف ما هي حروف الجوف طبعا في إن الجوف العام كمخرج
+
+22
+00:01:56,180 --> 00:02:00,460
+عامه وفي نفسه مخرج فرع يعني المخرج العام اللي هو
+
+23
+00:02:00,460 --> 00:02:06,360
+الجوف كم مخرج فرع يخرج منه؟ بس مخرج واحد وبيخرج من
+
+24
+00:02:06,360 --> 00:02:10,740
+المخرج الواحد اللي بنسميه أيضا الجوف ثلاث حروف ما
+
+25
+00:02:10,740 --> 00:02:14,480
+هي الحروف الثلاثة اللتي تخرجوا من الجوف اتفضل
+
+26
+00:02:14,480 --> 00:02:14,780
+اختير
+
+27
+00:02:20,360 --> 00:02:24,540
+صحيح يعني حروف المادة الثلاثة وحتى نكون دقيقين جدا
+
+28
+00:02:24,540 --> 00:02:29,760
+هو الألف الساكنة المفتوح ما قبلها والواو الساكنة
+
+29
+00:02:29,760 --> 00:02:34,380
+المضمون ما قبلها واليا الساكنة المكسور ما قبلها هل
+
+30
+00:02:34,380 --> 00:02:39,940
+يصح لنا أن نقول الألف والواو واليا فقط؟طبعا لأ لأن
+
+31
+00:02:39,940 --> 00:02:47,560
+هناك و متحركة مثل حرف و وي يعني الو وي الحروف
+
+32
+00:02:47,560 --> 00:02:53,860
+متحركة ليست حروف جوفية كذلك اليا يو إذا ليس من
+
+33
+00:02:53,860 --> 00:02:58,860
+الصواب أن نقول حروف المد الألف والوا واليا لابد أن
+
+34
+00:02:58,860 --> 00:03:02,840
+نقول حروف المد الألف الساكنةالمفتوح ما قبلها واللي
+
+35
+00:03:02,840 --> 00:03:05,740
+هو الساكنة المضمون ما قبلها واللي هي الساكنة
+
+36
+00:03:05,740 --> 00:03:11,160
+المكسور ما قبلها هذه هي حروف المادة لكن تسمية حروف
+
+37
+00:03:11,160 --> 00:03:15,540
+المادة تسمى بالحروف المادية وحروف الجوفية وحروف
+
+38
+00:03:15,540 --> 00:03:20,940
+العلة أما بالنسبة للجوف وهي طبعا لقب هذه الحروف
+
+39
+00:03:20,940 --> 00:03:26,180
+حروف المادة الثلاثة لقبها إيش يا أخوات جوفية لماذا
+
+40
+00:03:26,180 --> 00:03:31,060
+تلقب هذه الحروف الثلاثة بالجوفية؟لأنها تخرج من
+
+41
+00:03:31,060 --> 00:03:34,580
+الجوف وتسمى
+
+42
+00:03:34,580 --> 00:03:39,880
+حروف جوفية وتلقب بأنها حروف جوفية كذلك يطلق عليها
+
+43
+00:03:39,880 --> 00:03:43,420
+أيضا حروف العلة لماذا تسمى حروف علة؟
+
+44
+00:03:46,470 --> 00:03:50,630
+تسمى حروف العلة لتأوه العليل أي المريض إذا اشتك من
+
+45
+00:03:50,630 --> 00:03:51,030
+ألم
+
+46
+00:04:17,860 --> 00:04:22,820
+ويمتد الصوت إذا هي تسمى حروف الجوف لأنها تخرج من
+
+47
+00:04:22,820 --> 00:04:27,560
+الجوف وتلقب بيه تسمى حروف المد لامتداد الصوت معها
+
+48
+00:04:27,560 --> 00:04:32,540
+بسهولة و يسر عند النطق بحروف المد الثلاثة كذلك
+
+49
+00:04:32,540 --> 00:04:38,080
+تسمى حروف علة لأن المريض يتأوه بهذه الحروف يقول آه
+
+50
+00:04:38,570 --> 00:04:44,730
+و E عندما يتأوى وحروف الجوفية يا أخوات هي نفسها
+
+51
+00:04:44,730 --> 00:04:49,810
+حروف هوائية لماذا تسمى الحروف الجوفية أو الحروف
+
+52
+00:04:49,810 --> 00:04:53,130
+العلة أو الحروف المدح حروف جوفية أو حروف هوائية
+
+53
+00:04:53,130 --> 00:04:56,050
+لأنه فضل أخت
+
+54
+00:04:59,610 --> 00:05:05,230
+أحسنتي لأن حروف المادة ليس لها حيز تنتهي إليه بل
+
+55
+00:05:05,230 --> 00:05:10,450
+انتهاؤها بانتهاء النفس ما معنى هذه الجملة أن حروف
+
+56
+00:05:10,450 --> 00:05:15,510
+المادة أو الحروف الجوفية ليس لها حيز تنتهي إليه بل
+
+57
+00:05:15,510 --> 00:05:23,610
+انتهاؤها بانتهاء النفس يعني الواحد ممكن يقول اه
+
+58
+00:05:23,610 --> 00:05:26,910
+لما ينتهي نفسه
+
+59
+00:05:30,710 --> 00:05:37,740
+بنت نفسهنفس الموضوع إذا حروف المادة الثلاثة الألف
+
+60
+00:05:37,740 --> 00:05:40,680
+الساكنة المفتوح ما قبلها والواو الساكنة المضمون ما
+
+61
+00:05:40,680 --> 00:05:44,280
+قبلها واليأس الساكنة المكسور ما قبلها هي حروف
+
+62
+00:05:44,280 --> 00:05:48,940
+هوائية لأنه ليس لها حيز تنتهي إليه بل انتهاؤها
+
+63
+00:05:48,940 --> 00:05:53,780
+بانتهاء النفس ولذلك تسمى هذه الحروف من حروف الخفاء
+
+64
+00:05:53,780 --> 00:05:57,760
+المجموعة في قوله هاوي والتي سنأخذه ان شاء الله في
+
+65
+00:05:57,760 --> 00:06:02,100
+دروس قادمة هذا المخرج الأول يا أخوات المخرج الثاني
+
+66
+00:06:02,760 --> 00:06:09,020
+أين ما هو؟ الحلق وقلنا إن المخرج خمسة الجوف الحلق
+
+67
+00:06:09,020 --> 00:06:13,020
+الحلق طبعا الحلق اللي هو بعد ما بعد الحنجرة يعني
+
+68
+00:06:13,020 --> 00:06:18,220
+قبل اللسان فيه هناك يعني جزء من أيزاء الفم ويسمى
+
+69
+00:06:18,220 --> 00:06:24,630
+الحلق وهذا الحلق يشتمل على كام مخرج فرعي؟على ثلاثة
+
+70
+00:06:24,630 --> 00:06:29,450
+مخارج فرعية اللي هي أقصى الحلق من الآخر يعني مما
+
+71
+00:06:29,450 --> 00:06:33,570
+يالي الحنجرة أو نهاية القصفة الهوائية وسط الحلق
+
+72
+00:06:33,570 --> 00:06:38,810
+وأدنى الحلق أقصى الحلق وسط الحلق أدنى الحلق كأنه
+
+73
+00:06:38,810 --> 00:06:44,810
+في عندنا سلم بتلت درجات أقصى الحلق وهو أخر شيء
+
+74
+00:06:44,810 --> 00:06:50,820
+أقصى شيء من جهة الفم الخارج كذلك ياليه وسط الحلقو
+
+75
+00:06:50,820 --> 00:06:55,740
+بعد ذلك في عندنا أدنى الحلق أقصى الحلق بيخرج منه
+
+76
+00:06:55,740 --> 00:07:03,120
+حرفان ماهما الهمزة والها واصل الحلق بيخرج منه أيضا
+
+77
+00:07:03,120 --> 00:07:08,340
+حرفان وهما العين والها أدنى الحلق بيخرج منه حرفان
+
+78
+00:07:08,340 --> 00:07:12,260
+الغين والخار أما بالنسبة لأقصى الحلق يخرج منه
+
+79
+00:07:12,260 --> 00:07:16,780
+الهمزة والها إذا أردنا أن نتعرف على مخرج أي حرف
+
+80
+00:07:16,780 --> 00:07:23,770
+أخوات ماذا نفعلنأتي بالحرف ساكنة مسوق بهمزة نقول ا
+
+81
+00:07:23,770 --> 00:07:30,290
+ا من أين خرج حرف ال ا اما نشعر نشعر أثناء النطب ا
+
+82
+00:07:30,290 --> 00:07:36,030
+او اه اه من أقصى الحلقة يعني من أخر شيء في الحلقة
+
+83
+00:07:37,250 --> 00:07:42,070
+ووسط الحلق بيخرج منه حرف ال اع و ال اح بنشوف أنه
+
+84
+00:07:42,070 --> 00:07:48,170
+يطلع درجة يعني أقصى شيء ا و اه من أقصى الحلق اع و
+
+85
+00:07:48,170 --> 00:07:56,470
+اح ووسط الحلق اغ و اخ من أقصى الحلق هذه الست حروف
+
+86
+00:07:56,470 --> 00:08:00,510
+حرفان الهمزة و الها بيخرجوا من أقصى الحلق العين و
+
+87
+00:08:00,510 --> 00:08:04,350
+الحا بيخرجوا من وسط الحلق الغين و الخا بيخرجوا من
+
+88
+00:08:04,350 --> 00:08:11,390
+أدنى الحلقولقب هذه الحروف ما هي حروف حروف الحلق أو
+
+89
+00:08:11,390 --> 00:08:15,430
+حروف الحلقية مثل ما لقبنا حروف المادة الثلاثة
+
+90
+00:08:15,430 --> 00:08:20,190
+بالحروف الجوفية هذه الحروف نلقبها بالحروف الحلقية
+
+91
+00:08:20,190 --> 00:08:25,050
+هناك سبب لقبها بالحروف الجوفية لأنها تخرج من الجوف
+
+92
+00:08:25,050 --> 00:08:29,230
+وهنا الحروف الحلقية تلقب بالحروف الحلقية لأنها
+
+93
+00:08:29,230 --> 00:08:34,430
+تخرج من أين؟من الحرف هذا هو المخرج الثاني يعني لو
+
+94
+00:08:34,430 --> 00:08:40,830
+سألناكم حرف العين من أين هي الخرج؟واطل الحلق حرف
+
+95
+00:08:40,830 --> 00:08:48,090
+الها من أين يخرج؟ أقصى الحلق حرف الخ يخرج من أدنى
+
+96
+00:08:48,090 --> 00:08:53,750
+الحلق ننتقل إلى المخرج العام الثالث وهو اللسان
+
+97
+00:08:53,750 --> 00:08:58,770
+وهذا اللسان يعني بيخرج منه 18 حرف يعني عشر مخارج
+
+98
+00:08:58,770 --> 00:09:03,740
+لثمانية عشرة حرفايعني معظم حروف اللغة العربية تخرج
+
+99
+00:09:03,740 --> 00:09:08,360
+من وين؟ من اللسان لذلك اللسان مهم جدا و أصعب شيء
+
+100
+00:09:08,360 --> 00:09:13,880
+أصلا لأن في عندنا عشر مخارج فرعية بتخرج من اللسان
+
+101
+00:09:13,880 --> 00:09:19,820
+ب 18 حرف من حروف اللغة العربية لكن قبل أن ندخل على
+
+102
+00:09:19,820 --> 00:09:24,440
+اللسان نتعرف على أجزاء اللسان اللسان طبعا في عندنا
+
+103
+00:09:24,440 --> 00:09:29,040
+طرف اللسان وهو مما يلي الشفتين اللي هو رأس اللسان
+
+104
+00:09:29,040 --> 00:09:32,850
+طرف اللسان اللي هو طرف اللسانهذا الجزء الأول يعني
+
+105
+00:09:32,850 --> 00:09:38,550
+في عندنا حفتي اللسان لو قلنا نعتبر أن يدي هذه هي
+
+106
+00:09:38,550 --> 00:09:43,000
+اللسان طرف اللسان هي المنطقة هذهاللي هي رأس
+
+107
+00:09:43,000 --> 00:09:49,780
+اللسان، طرف اللسان أو الطرف، حفتي اللسان له حافة
+
+108
+00:09:49,780 --> 00:09:54,820
+يمنى، هي حافة يمنى وحافة يسرة، اسمه حافتي اللسان،
+
+109
+00:09:54,820 --> 00:09:59,380
+حافة يمنى وحافة يسرة، وسط اللسان اللي هي المنطقة
+
+110
+00:09:59,380 --> 00:10:04,280
+هذه، نعتبر أن هذا وسط اللسانفي عندنا أقصى اللسان
+
+111
+00:10:04,280 --> 00:10:07,840
+اللي هو المنطقة هذه أقصى اللسان مثلا هذا اللسان
+
+112
+00:10:07,840 --> 00:10:12,420
+أقصى اللسان وسط اللسان رأس اللسان حافة اللسان
+
+113
+00:10:12,420 --> 00:10:16,440
+اليمنى حافة اللسان اليسرى في عندنا يا أخوات ظهر
+
+114
+00:10:16,440 --> 00:10:22,000
+اللسان اللي هي المنطقة هذه فوق ظهر اللسان بطن
+
+115
+00:10:22,000 --> 00:10:26,200
+اللساناللي هي اللي اتحاد في عيننا الحنك الأعلى
+
+116
+00:10:26,200 --> 00:10:30,400
+والحنك الأسفل الحنك الأعلى اللي هو ما يعلي اللسان
+
+117
+00:10:30,400 --> 00:10:34,700
+من العضمة اللتي في سجف الحلج نسميها سجف الحلج أو
+
+118
+00:10:34,700 --> 00:10:40,370
+مثلا الحنك الأعلى يسمى الذي يغطي اللسانيسمى الحنك
+
+119
+00:10:40,370 --> 00:10:44,890
+الأعلى وفي عندنا حنك أسفل اللي هو إلى أسفل اللسان
+
+120
+00:10:44,890 --> 00:10:50,710
+إذا هذه أجزاء اللسان و الحنك الأعلى و الحنك الأسفل
+
+121
+00:10:50,710 --> 00:10:55,830
+من هذه الأجزاء يا أخوات تخرج المخارج الخاصة أو
+
+122
+00:10:55,830 --> 00:11:00,810
+الفرعية من اللسان اللسان قلنا كم مخرج فرعي بيخرج
+
+123
+00:11:00,810 --> 00:11:07,040
+من اللسان عشرة مخرج فرعي نبدأ بالمخرج الأولالمخرج
+
+124
+00:11:07,040 --> 00:11:11,040
+الأول لن نبدأه من طرف سنبدأ من الأقصى و ننزل تحت
+
+125
+00:11:11,040 --> 00:11:15,940
+نعتبر أن هذه إيدي هي اللسان لو كان في عنا صور أفضل
+
+126
+00:11:15,940 --> 00:11:20,900
+أقصى اللسان المنطقة هذه مثلا مع ما يحاذيها من
+
+127
+00:11:20,900 --> 00:11:24,740
+الحنك الأعلى الحنك الأعلى اللي هو السجف الحلق
+
+128
+00:11:24,740 --> 00:11:28,460
+الحنك الأعلى سجف الحلق فعندما أقول أقصى اللسان مع
+
+129
+00:11:28,460 --> 00:11:33,260
+ما يحاذيها من الحنك الأعلى بيخرج منه حرف القافحرف
+
+130
+00:11:33,260 --> 00:11:39,580
+الأقق حتى نحن عندما نقول اقق اقق نجد أن أقصى
+
+131
+00:11:39,580 --> 00:11:45,100
+اللسان التسقة بالحنك الأعلى فحصر الصوت و كذلك
+
+132
+00:11:45,100 --> 00:11:50,520
+النفس ثم انفتح المخرج فخرجت منه النبرة التي نسميها
+
+133
+00:11:50,520 --> 00:11:55,160
+القلقلة إذا أقصى اللسان مع ما يحاذيه من الحنك
+
+134
+00:11:55,160 --> 00:12:03,540
+الأعلى يخرج منه حرف القاف نقول أنهأقصى اللسان مع
+
+135
+00:12:03,540 --> 00:12:07,220
+ما يحاذيه من الحنك الأعلى بيخرج منه حرف واحد و هو
+
+136
+00:12:07,220 --> 00:12:13,860
+حرف القاف بعد ذلك يأتي الحرف اللذي يليه و هو نقول
+
+137
+00:12:13,860 --> 00:12:19,960
+اك اك بيخرج أيضا حرف الكاف من أقصى اللسان أسفل
+
+138
+00:12:19,960 --> 00:12:24,140
+مخرج حرف القاف مع ما يحاذيه من الحنك الأعلى نقول
+
+139
+00:12:24,140 --> 00:12:30,230
+اكو نحن نجد هنا أن الأقط أول شي أقصى اللسان مع ما
+
+140
+00:12:30,230 --> 00:12:35,510
+يحاذيها من الحناك الأعلىبعد ذلك المخرج اللذي يليه
+
+141
+00:12:35,510 --> 00:12:41,190
+بيأتي حرف الكاف وبيخرج من أقصى اللسان ولكن لابد أن
+
+142
+00:12:41,190 --> 00:12:45,630
+نقول أسفى المخرج حرف القاف مع ما يحاذيه من الحنك
+
+143
+00:12:45,630 --> 00:12:50,450
+الأعلى وبيخرج منه حرف ال إك يعني لو صورنا أن هذه
+
+144
+00:12:50,450 --> 00:12:54,070
+يد اللسان أقصى اللسان من الجهة هذه و هذا الحنك
+
+145
+00:12:54,070 --> 00:12:58,600
+الأعلى نقولها أقصى اللسانيعني أقصى اللسان مع
+
+146
+00:12:58,600 --> 00:13:02,920
+ميحادير الحناك الأعلى ال إك أقصى اللسان أسفل مخرج
+
+147
+00:13:02,920 --> 00:13:08,880
+حرف الكهف يعني المنطقة هذه نقولها إكبنجد أن أقصى
+
+148
+00:13:08,880 --> 00:13:12,360
+اللسان أسفل مخرج حرف القاف التسقى بالحناك الأعلى
+
+149
+00:13:12,360 --> 00:13:17,380
+فخرج منه حرف الكاف هي المخرج الثاني وهذا الحرفان
+
+150
+00:13:17,380 --> 00:13:21,760
+يا أخوات اللي هو حرف القاف وحرف الكاف يطلق عليهم
+
+151
+00:13:21,760 --> 00:13:26,800
+أو يلقبان بالحرفين اللهويين لماذا يطلق عليهم
+
+152
+00:13:26,800 --> 00:13:33,090
+بالحرفين اللهويين؟ فضل أختكيخرجان بالقرب من اللهاء
+
+153
+00:13:33,090 --> 00:13:37,150
+واللهاء هي اللحمية التي تكون في أقصى الحنك الأعلى
+
+154
+00:13:37,150 --> 00:13:42,490
+والملتسق فيها لسان المزمار هذه اللهاء فلأن حرف
+
+155
+00:13:42,490 --> 00:13:47,830
+القاف وحرف الكاف يخرجان بالقرب من اللهاء يطلق على
+
+156
+00:13:47,830 --> 00:13:52,710
+حرف القاف والكاف الحرفان اللهويان هذه عندنا المخرج
+
+157
+00:13:52,710 --> 00:13:56,930
+الثاني والمخرج الثالث يا أخوات بيخرج منه ما هي
+
+158
+00:13:56,930 --> 00:14:00,720
+الحروف اللي تخرج من المخرج الثالث؟اللي هي الجيم
+
+159
+00:14:00,720 --> 00:14:07,180
+والشين واليا وتخرج من وسط اللسان مع ما يحاذيه من
+
+160
+00:14:07,180 --> 00:14:15,320
+الحنك الأعلى نقول اج اج ولنحضر من أن نقوله ج جلو
+
+161
+00:14:15,320 --> 00:14:31,860
+اششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششششش
+
+162
+00:14:43,470 --> 00:14:46,830
+اللياء المتحرك وليس اللياء المادية اللياء المادية
+
+163
+00:14:46,830 --> 00:14:53,550
+بتخرج كما قلنا من الجوف نقول المؤمنين لكن اللياء
+
+164
+00:14:53,550 --> 00:15:00,930
+المتحرك مثل كلمة يأكل يلعب ينام يعملون هذا حرف
+
+165
+00:15:00,930 --> 00:15:06,370
+اللياء متحرك وليس فيه مادية ليس حرف مدهو إنما حرف
+
+166
+00:15:06,370 --> 00:15:09,920
+يخرجهمن وسط اللسان مع ما يحاذيه من الحناك الأعلى
+
+167
+00:15:09,920 --> 00:15:16,200
+وهذا لقبه شجري لأن الحروف التي تخرج من وسط اللسان
+
+168
+00:15:16,200 --> 00:15:21,100
+مع ما يحاذيه من الحناك الأعلى لقبها نلقبها شجرية
+
+169
+00:15:21,100 --> 00:15:26,060
+لأنها تخرج من شجر الفم يعني أوسع جزء بالفم يعني
+
+170
+00:15:26,060 --> 00:15:31,820
+متسعة من الفم إذا حروف هذه المخرج الثالث وسط
+
+171
+00:15:31,820 --> 00:15:32,780
+اللسان ال
+
+172
+00:15:35,550 --> 00:15:40,150
+ال إش .. طب عندنا نقول شين و عندنا نقول إش لأنه
+
+173
+00:15:40,150 --> 00:15:43,810
+إذا أردنا نتعرف على مخرج أي حرف ماذا نفعل يا أخوات
+
+174
+00:15:43,810 --> 00:15:49,010
+نأتي بالحرف الساكن أو مشددا مسوقا بهمزا و ننطق
+
+175
+00:15:49,010 --> 00:15:53,790
+الحرف فحيثما انحصر الصوت فهو مخرجه فانا عندما أقول
+
+176
+00:15:53,790 --> 00:15:59,030
+إش أجد أن الريح ينتشر في الفم لكن المخرج يكون من
+
+177
+00:15:59,030 --> 00:16:06,870
+وسط الفم ال إجأج و إش و يأ يو يعني اليأ المتحركة
+
+178
+00:16:06,870 --> 00:16:10,650
+وهذه الحروف الثلاثة التي تخرج من وسط اللسان مع ما
+
+179
+00:16:10,650 --> 00:16:14,470
+يحدث من حناك الأعلى نسميها أو نلقيبها بالحروف
+
+180
+00:16:14,470 --> 00:16:20,500
+الشجريةالمخرج الرابع يا أخوات من مخرج حرف ال .. او
+
+181
+00:16:20,500 --> 00:16:25,080
+من مخرج اللسان طبعا اللسان مخرج وعام له عشرة مخرج
+
+182
+00:16:25,080 --> 00:16:28,080
+أخدنا أقصى اللسان مع ما يحديه من الحناك الأعلى
+
+183
+00:16:28,080 --> 00:16:31,880
+بيخرج منه حرف القاف أقصى اللسان أسفى المخرج حرف
+
+184
+00:16:31,880 --> 00:16:35,680
+القاف مع ما يحديه من الحناك الأعلى وبيخرج منه حرف
+
+185
+00:16:35,680 --> 00:16:40,400
+الكاف ال إك ووسط اللسان مع ما يحديه من الحناك
+
+186
+00:16:40,400 --> 00:16:44,880
+الأعلى وبيخرج منه ثلاثة حروف اللي هي الجيم والشين
+
+187
+00:16:44,880 --> 00:16:51,650
+واليمأما المخرج الرابع فهو مخرج حرف الضاد والضاد
+
+188
+00:16:51,650 --> 00:16:56,130
+هي يعني انتزت فيها اللغة العربية التي تسمى أو تطلق
+
+189
+00:16:56,130 --> 00:17:00,770
+عليها بلغة الضاد لأنه لا يوجد أي لغة في العالم
+
+190
+00:17:00,770 --> 00:17:04,450
+فيها حرف الضاد يعني أي لغة في العالم بيلفظ حرف
+
+191
+00:17:04,450 --> 00:17:09,770
+الضاد ذال واحد لو اسمه ظاهرنقول ذاهر يكتب حرف
+
+192
+00:17:09,770 --> 00:17:13,970
+الدال لكن حرف الضاد هو حرف امتزد فيه اللغة العربية
+
+193
+00:17:13,970 --> 00:17:19,190
+فهي لغة الضاد إذا مخرج حرف الضاد يخرجه من إحدى
+
+194
+00:17:19,190 --> 00:17:24,950
+حافتي اللسان اليمنى أو اليسرى ومن اليسرى أسهل مع
+
+195
+00:17:24,950 --> 00:17:28,570
+ما يليها من أدراس الجهة العليا يعني هي اللسان مثلا
+
+196
+00:17:28,570 --> 00:17:32,880
+يدي اللسان الجهة اليمنى هي الجهة اليمنىأو الجهة
+
+197
+00:17:32,880 --> 00:17:37,980
+اليسرى إحدى حفتين لسان اليمنى أو اليسرى ولكن من
+
+198
+00:17:37,980 --> 00:17:41,960
+اليسرى أيسر مع ما يليها من أضراس الجهة العليا
+
+199
+00:17:41,960 --> 00:17:49,710
+فنقول اض اض اض فو هكذا ولا نقول اد ولا اضإنما هي
+
+200
+00:17:49,710 --> 00:17:54,550
+أب و لا الضالين يعني الحافة اليمنى أو الحافة
+
+201
+00:17:54,550 --> 00:17:59,250
+اليسرى و يجب أن نخرجها من الحافتين و لكن الأيسر
+
+202
+00:17:59,250 --> 00:18:04,710
+الحافة اليسرى أو يخرج منه حرف الأب اللي هو مثل و
+
+203
+00:18:04,710 --> 00:18:11,770
+لا الضالين و حرفحرف الضاد يا أخوات قال بعض العلماء
+
+204
+00:18:11,770 --> 00:18:18,330
+أن لقبه يعني يلحق بالحروف الشجرية وليس هناك إجماعة
+
+205
+00:18:18,330 --> 00:18:22,230
+ما بين العلماء يعني لو سألنا .. لو سألنا سؤال أن
+
+206
+00:18:22,230 --> 00:18:28,220
+أجمع العلماء على أن حرف الضاد شجرييعني من الحروف
+
+207
+00:18:28,220 --> 00:18:32,900
+الشجرية نقول هذا خطأ لأنها ليست إجماعا وإنما ذكر
+
+208
+00:18:32,900 --> 00:18:38,620
+بعض العلماء أن لقب حرف الضاضل لأنه بيخرج من وسط
+
+209
+00:18:38,620 --> 00:18:42,560
+اللسان تقريبا إحدى حافتين لسان اليمن أو اليسرى ومن
+
+210
+00:18:42,560 --> 00:18:47,660
+اليسرى أيسر قالوا أن لقبه شجري وليس هناك إجماع على
+
+211
+00:18:47,660 --> 00:18:52,870
+ذلك هذا يا أخوات هو المخرج الرابعمن مخرج اللسان
+
+212
+00:18:52,870 --> 00:18:59,830
+ننزل قليلا هنجد أن هناك المخرج الخامس وهو مخرج حرف
+
+213
+00:18:59,830 --> 00:19:05,490
+اللام مخرج حرف اللام من أين يخرج؟ يخرج من أدنى
+
+214
+00:19:05,490 --> 00:19:11,510
+حفتي اللسان مع ما يحاذيه من لثة الأسنان العلياأدنى
+
+215
+00:19:11,510 --> 00:19:14,710
+حافتين لسان يعني اعتبرنا ان هذا اللسان أدنى
+
+216
+00:19:14,710 --> 00:19:18,590
+الحافتين هذه الحافة اليمنى وهذه الحافة اليسرى أدنى
+
+217
+00:19:18,590 --> 00:19:21,690
+الحافتين يعني أقرب الحافتين يعني المنطقة هذه
+
+218
+00:19:21,690 --> 00:19:27,530
+المنطقة هذه كلها تسمى أدنى حافتين لسان مع ما يليها
+
+219
+00:19:27,530 --> 00:19:32,110
+من لثة الأسنان العليا الأسنان العليا عندما نقول يا
+
+220
+00:19:32,110 --> 00:19:38,770
+أخوات الأسنان العليا ماذا تشمل؟تشمل الثانيتين اللي
+
+221
+00:19:38,770 --> 00:19:44,050
+هم السنين هدولة، التانيتين، وتشمل الرباعيتين اللي
+
+222
+00:19:44,050 --> 00:19:49,390
+بعد الثانية، وتشمل النابين، الناب هذا و الناب هذا،
+
+223
+00:19:49,390 --> 00:19:55,020
+وتشمل الضحكين اللي هو أول درس بعد النابإذا هذه
+
+224
+00:19:55,020 --> 00:20:01,540
+تسمى الأسنان العليا فعندما نقول حرف ال ال ال نجد
+
+225
+00:20:01,540 --> 00:20:07,220
+أنه أدنى حفتين لسان التسقوا بلثة الأسنان العليا
+
+226
+00:20:07,220 --> 00:20:12,620
+فخرج منه حرف ال ال يعني ليس اترأس اللسان إنما ال
+
+227
+00:20:12,620 --> 00:20:17,240
+أدنى حفتين لسان مع ما يليها من لثة الأسنان العليا
+
+228
+00:20:17,240 --> 00:20:20,440
+التي تجتمل على الثانيتين
+
+229
+00:20:22,630 --> 00:20:29,010
+زاد أربعيتين اللي بعدها زاد النابين زاد الضحكين
+
+230
+00:20:29,010 --> 00:20:33,870
+وهو أول درس بعد الناب لماذا يطلق على الضحكين
+
+231
+00:20:33,870 --> 00:20:39,810
+بالضحكين؟لأن هما لا يبدوان إلا عند الضحك يعني
+
+232
+00:20:39,810 --> 00:20:43,810
+عندما يتكلم الإنسان أكتر شيء بيظهر الناب بيظهر
+
+233
+00:20:43,810 --> 00:20:49,010
+الرباعية أو الأسنان لكن متى يظهر الضحكين عندما
+
+234
+00:20:49,010 --> 00:20:54,730
+يضحك الإنسان تنفتح الشفتين فيظهر الضحكين لذلك لأن
+
+235
+00:20:54,730 --> 00:20:59,570
+هما لا يبدوان إلا عند الضحك يطلق على هذين الدرسين
+
+236
+00:20:59,570 --> 00:21:06,160
+الذين يلي الناب يطلق عليهم إيش الضحكينهذا المخرج
+
+237
+00:21:06,160 --> 00:21:11,520
+الخامس المخرج السادس يا أخوات و هو مخرج حرف النون
+
+238
+00:21:11,520 --> 00:21:18,420
+و مخرج حرف النون يخرج من طرف اللسان أسفل مخرج حرف
+
+239
+00:21:18,420 --> 00:21:23,760
+اللام مع ما يحاذيه من لثة الثنايا العليا الثنايا
+
+240
+00:21:23,760 --> 00:21:28,940
+العليا هدول السنين القواطع يسمى الثنايا العليا
+
+241
+00:21:29,500 --> 00:21:34,360
+اللثة اللي هي اللحمية اللتي تنغرز فيها الثناية
+
+242
+00:21:34,360 --> 00:21:37,880
+العليا يعني اللحمية من الداخل لحمة الفم من الداخل
+
+243
+00:21:37,880 --> 00:21:43,600
+حول الثناية العليا يسمى لثة الثناية العليا ويخرج
+
+244
+00:21:43,600 --> 00:21:47,660
+منه حرف النون يبقى طرف اللسان مع ما يليه من لثة
+
+245
+00:21:47,660 --> 00:21:52,980
+الثناية العليا أسفل مخرج حرف اللام لازم نقول أسفل
+
+246
+00:21:52,980 --> 00:22:00,050
+مخرج حرف اللام بيخرج منه حرف النون فلقول inان أنا
+
+247
+00:22:00,050 --> 00:22:05,450
+عندما أقول in أجد أنه طرف اللسان التسقى بلثة
+
+248
+00:22:05,450 --> 00:22:11,630
+الثناء العليا فخرج منه حرف ال in وحرف ال in أسفل
+
+249
+00:22:11,630 --> 00:22:17,350
+مخرج حرف ال lambالمخرج الذي يليه هو المخرج السابع
+
+250
+00:22:17,350 --> 00:22:23,150
+وهو مخرج حرف الرا حرف الرا يخرج من ظهر طرف اللسان
+
+251
+00:22:23,150 --> 00:22:28,530
+أسفل مخرج حرف النون مع ما يليه من لثة الثنايا
+
+252
+00:22:28,530 --> 00:22:36,010
+العليا يعني بالترتيب اللام نون را اللام أدنى حفتين
+
+253
+00:22:36,010 --> 00:22:41,870
+لسان مع لثة الثنايا العليا كلهاالنون أسفة الرأس
+
+254
+00:22:41,870 --> 00:22:46,170
+اللسان أو طرف اللسان أسفة المخرج حرف اللام مع ما
+
+255
+00:22:46,170 --> 00:22:51,970
+يليه من لثة الثنايا العليا وليست الأسنان العليا
+
+256
+00:22:51,970 --> 00:22:57,160
+وهذا المخرج الخامس المخرج السابعأسفل المخرج السابع
+
+257
+00:22:57,160 --> 00:23:01,060
+اللي هي ظهر طرف اللسان أو طرف اللسان مائدا إلى
+
+258
+00:23:01,060 --> 00:23:06,480
+الظهري أسفل مخرج حرف النون مع ما يليه من لثة
+
+259
+00:23:06,480 --> 00:23:12,960
+الثناية العليا بيخرج منه حرف ال ار ار ارهذا المخرج
+
+260
+00:23:12,960 --> 00:23:16,700
+التلاتة هذه الحروف التلاتة اللي هو مخرج الـ Lam
+
+261
+00:23:16,700 --> 00:23:22,220
+والنون والرا هي عندنا تلات مخرج عند الشاطبي
+
+262
+00:23:22,220 --> 00:23:26,780
+اعتبارها مخرج واحد او عند الفراء اعتبارها مخرج
+
+263
+00:23:26,780 --> 00:23:32,620
+واحد لذلك دمج هذه المخرج التلاتة قال بدل ان يقول
+
+264
+00:23:34,040 --> 00:23:39,000
+طرف الأدنى حافتين اللسان وطرف اللسان و اللام و
+
+265
+00:23:39,000 --> 00:23:43,000
+النون و الراء اعتبارها كلها طرف اللسان مع لثة
+
+266
+00:23:43,000 --> 00:23:46,760
+الثناء العليا او الأسنان العليا واعتبارها كلها
+
+267
+00:23:46,760 --> 00:23:50,880
+مخرج واحد لكن عندنا .. عندنا نحن على حسب ابن
+
+268
+00:23:50,880 --> 00:23:57,360
+الجزرياعتبارها ان ثلاث مخارج مخرج للام مخرج للنون
+
+269
+00:23:57,360 --> 00:24:03,300
+مخرج الرا اللام أدنى حفتين لسان مع ما يليه من لثة
+
+270
+00:24:03,300 --> 00:24:08,700
+الأسنان العليا النون طرف اللسان مع ما يليه من لثة
+
+271
+00:24:08,700 --> 00:24:14,850
+الثنايا العليا أسفل مخرج حرف اللام الراظهر طرف
+
+272
+00:24:14,850 --> 00:24:18,990
+اللسان أو طرف اللسان مائلا إلى الظهري أسفل مخرج
+
+273
+00:24:18,990 --> 00:24:23,090
+حرف النون بالترتيب مع ما يليه من لثة الثناء العليا
+
+274
+00:24:23,090 --> 00:24:28,310
+وبيخرج منه حرف الرا وهذه الحروف التلاتة كلها التي
+
+275
+00:24:28,310 --> 00:24:32,550
+هي تلات مخارج يعني يطلق عليها أو يتلقب بالحروف
+
+276
+00:24:32,550 --> 00:24:37,810
+الذلقية لأنها تخرج من ذلق اللسان اللي هو طرف
+
+277
+00:24:37,810 --> 00:24:42,890
+اللسانننتقل يا أخوات إلى المخرج الثامن والمخرج
+
+278
+00:24:42,890 --> 00:24:50,050
+الثامن يخرج منه حرف ت والدال والط وهي من ظهر طرف
+
+279
+00:24:50,050 --> 00:24:55,310
+اللسان مع ما يليه من أصول الثناء العليا ما معنى يا
+
+280
+00:24:55,310 --> 00:24:59,510
+أخوات أصول الثناء العليا؟أصول الثنايا العليا ليست
+
+281
+00:24:59,510 --> 00:25:06,850
+الأطراف هذه وإنما الثنايا العليا عندما تنغرز بالفك
+
+282
+00:25:06,850 --> 00:25:10,170
+العلوي هذا هو أصول الثنايا العليا يعني الجذر نفسه
+
+283
+00:25:10,170 --> 00:25:14,150
+جذر الثنايا العليا يعني الجذر الثنايا وهو المكان
+
+284
+00:25:14,150 --> 00:25:18,230
+الذي ينغرزه في الأسنان يسمى أصول الثنايا العليا
+
+285
+00:25:18,230 --> 00:25:25,100
+فعندما أقول ات و اطو إد أجد أنه ظهر طرف اللسان
+
+286
+00:25:25,100 --> 00:25:29,820
+التسقى مع أصول الثانية العليا وخرجت منه هذه الحروف
+
+287
+00:25:29,820 --> 00:25:36,620
+حرف الات والأت والإد إذا هذا هو المخرج رقم ثمانية
+
+288
+00:25:36,620 --> 00:25:45,670
+كذلك لقب هذه الحروف تسمى نطعيةيعني الات والاط
+
+289
+00:25:45,670 --> 00:25:52,050
+والاد تسمى أو تلقى بالحروف النطعية لأنها تخرج من
+
+290
+00:25:52,050 --> 00:25:58,320
+نطع الفمي وهي بداية منفتح الفم فانا عندما اقوليعني
+
+291
+00:25:58,320 --> 00:26:06,100
+يضيق فمي فبداية انفتاح الفم بيسمى نطع الفم فلأن
+
+292
+00:26:06,100 --> 00:26:11,480
+حرف ال it و ال it و ال it بتخرج عندما تضيق فترة
+
+293
+00:26:11,480 --> 00:26:16,080
+الشفتين و بيخرج بسمى نطع الفم يعني بداية منفتاح
+
+294
+00:26:16,080 --> 00:26:21,000
+الفم تلقى بهذه الحروف و حرف ال it و ال it و ال it
+
+295
+00:26:21,000 --> 00:26:26,260
+تلقى بالحروف النطعية هذا يا أخوات هو المخرج رقم 8
+
+296
+00:26:27,020 --> 00:26:34,980
+المخرج التاسع وهو مخرج حرف الصين والصاد والزايدS و
+
+297
+00:26:34,980 --> 00:26:43,200
+S و IZ هذه الحروف تسمى الحروف الأسلية وتخرج من طرف
+
+298
+00:26:43,200 --> 00:26:48,500
+اللسان مع ما بين أطراف الثنايا العليا والسفلة يعني
+
+299
+00:26:48,500 --> 00:26:52,980
+تخرج من طرف اللسان أو من أسل اللسان و مع ما بين
+
+300
+00:26:52,980 --> 00:26:58,820
+أطراف الثنايا العليا والسفلة مع بقاء فرجة بسيطة ما
+
+301
+00:26:58,820 --> 00:27:06,230
+بين الأسنان تخرج منها ال Sو ال أس و ال از و هذه
+
+302
+00:27:06,230 --> 00:27:10,610
+الحروف تلقبوا بالحروف الأسلية لأنها تخرج من أسل
+
+303
+00:27:10,610 --> 00:27:16,710
+اللسان أو من أسل الفم يعني بمعنى ما استذقه من
+
+304
+00:27:16,710 --> 00:27:22,300
+اللسان هذا مخرج رقم تسعة إذا المخرج التاسعيخرجوا
+
+305
+00:27:22,300 --> 00:27:29,040
+حرف الصين والزاى والصاد يخرجوا من طرف اللسان أو ما
+
+306
+00:27:29,040 --> 00:27:34,120
+استدق من طرف اللسان بين أطراف الثانية العليا
+
+307
+00:27:34,120 --> 00:27:40,940
+والسفلة فيخرج منهم حرف الاس والأس والإز وتلقب هذه
+
+308
+00:27:40,940 --> 00:27:45,380
+الحروف بالحروف الأسلية لأنها تخرج من أين يا أخوات؟
+
+309
+00:27:45,380 --> 00:27:51,170
+من أسل اللسان ما معنى أسل اللسان؟يعني ماذقة من طرف
+
+310
+00:27:51,170 --> 00:27:56,410
+اللسان يعني طرف طرف اللسان أو رأس اللسان فانا
+
+311
+00:27:56,410 --> 00:28:00,030
+عندما يعني أقول أن هذا هو طرف اللسان ماذقة من طرف
+
+312
+00:28:00,030 --> 00:28:03,290
+اللسان يعني رأس اللسان رأس الدبوس مثلا رأس الدبوس
+
+313
+00:28:03,290 --> 00:28:10,680
+بالنسبة للدبوس فأقول مثلاأس إذ هذه الحروف اللي هي
+
+314
+00:28:10,680 --> 00:28:15,340
+تخرج من أس لللسان أو ما دقة من طرف اللسان مع ما
+
+315
+00:28:15,340 --> 00:28:18,700
+بين أطراف الثانية العليا والسفلة فيخرج منه حرف
+
+316
+00:28:18,700 --> 00:28:25,560
+الاس والأس والإذ ننتقل إلى آخر مخرج من مخارج
+
+317
+00:28:25,560 --> 00:28:32,450
+اللسان الفرعية وهو مخرج حرف ال إثو ال اذ و ال اض و
+
+318
+00:28:32,450 --> 00:28:37,230
+يخرجوا من ظهر طرف اللسان مع أطراف بالتساقه مع
+
+319
+00:28:37,230 --> 00:28:43,840
+أطراف الثنايا العليا والسفلة فنقول اذو اظ و اث
+
+320
+00:28:43,840 --> 00:28:48,980
+وهذه الحروف التي نجد ان كثير من الناس لا يخرجها من
+
+321
+00:28:48,980 --> 00:28:56,080
+مخرجها فيقول عن حرف ال اذ ايش اذ يقولون ذلك الكتاب
+
+322
+00:28:56,080 --> 00:29:02,940
+او الذهب ليس ذهب و ليس ذلك خطأ انما هي ذلك الكتاب
+
+323
+00:29:02,940 --> 00:29:09,370
+كذلك حرف ال اثبيخرجونه من مخرج حرف ال S فيقول ثمة
+
+324
+00:29:09,370 --> 00:29:14,910
+ثيبات وأبكارة وهذا خطأ هي ثيبات وأبكارة أو نقول
+
+325
+00:29:14,910 --> 00:29:22,210
+ثمة كذلك حرف الأض يقولون ظهر الحق يخرجون حرف الأض
+
+326
+00:29:22,210 --> 00:29:28,170
+من مخرج حرف الزي طبعا ليس لنقول زهرة وإنما ظهرة
+
+327
+00:29:28,170 --> 00:29:33,110
+إذا هذه الحروف تخرجوا من طرف اللسان بالتساقه مع
+
+328
+00:29:33,110 --> 00:29:40,080
+أطراف الثنايا العليافيقول اذ و اذ و اث حتى انه
+
+329
+00:29:40,080 --> 00:29:47,680
+يبدو جزء بسيط من اللسان خارج الأسنان وهذه الحروف
+
+330
+00:29:47,680 --> 00:29:53,020
+الثلاثة الاذال والظا والثان تلقب بالحروف اللثوية
+
+331
+00:29:53,020 --> 00:29:58,210
+انتهينا يا أخوات من مخرجاللسان في عندنا أخر شيء
+
+332
+00:29:58,210 --> 00:30:03,610
+اللي هو مخرج الشفتين و الشفتين له مخرجان مخرج واحد
+
+333
+00:30:03,610 --> 00:30:07,730
+بيخرج منه حرف الف و هو من أطراف .. عند وضع أطراف
+
+334
+00:30:07,730 --> 00:30:15,140
+الثلالي عليا على بطن الشفة السفلة فنقول Fإذا
+
+335
+00:30:15,140 --> 00:30:19,360
+الشفتين و هو المخرج رقم أربع من المخرج العامة
+
+336
+00:30:19,360 --> 00:30:24,320
+بيخرج منه مخرجين فرعيين و المخرج الأول عند وضع
+
+337
+00:30:24,320 --> 00:30:28,720
+أطراف الثانية العليا هذولة على بطن الشفة السفلة
+
+338
+00:30:28,720 --> 00:30:35,650
+فنقول if ifو هذا مخرج حرف الفة و المخرج الثاني
+
+339
+00:30:35,650 --> 00:30:41,150
+يخرج أخوات من بين الشفتين و يخرج منه ال ميم و ال
+
+340
+00:30:41,150 --> 00:30:46,990
+با و ال واو ال ميم نقول ام عند انطباق الشفتين إلى
+
+341
+00:30:46,990 --> 00:30:52,910
+الخارج و اب عند انطباق الشفتين إلى الداخل فنقول ام
+
+342
+00:30:52,910 --> 00:30:58,680
+و ابالـ B عند الذاكرة B والـ M إلى الخارج حرف ال
+
+343
+00:30:58,680 --> 00:31:03,300
+ميم والبا أما الواو أيضا بيخرج من بين الشفتين ولكن
+
+344
+00:31:03,300 --> 00:31:07,640
+عند ضم الشفتين وانفراجهما وبيخرج منه الواو
+
+345
+00:31:07,640 --> 00:31:13,920
+المتحركة هذه الحروف كلها الفا والواو والميم والبا
+
+346
+00:31:13,920 --> 00:31:18,980
+لقبها شفائية إذا ما هي ألقاب حرف ال ميم والبا
+
+347
+00:31:18,980 --> 00:31:23,420
+والواو والميم؟شفوية، إذا في عندنا مخرجين بيخرج من
+
+348
+00:31:23,420 --> 00:31:29,040
+الشفتين، مخرج للف و مخرج للميم و البا و الواو،
+
+349
+00:31:29,040 --> 00:31:33,860
+المادية ولا المتحركة؟ المتحركة لإن أنا أنا أقول و
+
+350
+00:31:33,860 --> 00:31:41,610
+ويطبعا في عندنا مثلا المخرج الأخير و هو مخرج
+
+351
+00:31:41,610 --> 00:31:47,190
+الخيشوم و مخرج الخيشوم هو أقصى الأنف من الداخل و
+
+352
+00:31:47,190 --> 00:31:53,690
+يجتمل على مخرج واحد و هو عبارة عن صفة و ليس له
+
+353
+00:31:53,690 --> 00:31:58,350
+حروف يعني لا نقول أن حرف النون و ال ميم تخرج من
+
+354
+00:31:58,350 --> 00:32:02,750
+الخيشوم و إنما هي صفة إذا ما هي الحروف التي تخرج
+
+355
+00:32:02,750 --> 00:32:09,070
+من الخيشومليس هناك حرفا وانما هي صفة ويتسمى الغنى
+
+356
+00:32:09,070 --> 00:32:15,150
+صفة الغنى وصوت و هو صوت أغن يخرج من الخيشوم لعمل
+
+357
+00:32:15,150 --> 00:32:20,810
+اللسان به مقدار حركتين و هو صفة ملازمة لحرفي ال
+
+358
+00:32:20,810 --> 00:32:27,050
+ميم و النون إذا المخرج الخامسهو مخرج الخيشوم وهو
+
+359
+00:32:27,050 --> 00:32:32,970
+أعلى الأنث بيخرج منه صفة صفة الغنّة وصفة الغنّة
+
+360
+00:32:32,970 --> 00:32:38,750
+ليست حرفا بل هي صفة ملازمة للميم والنون والغنّة
+
+361
+00:32:38,750 --> 00:32:43,610
+كما أعرفها العلماء هي صوت أغنّ يخرج من الخيشوم
+
+362
+00:32:43,610 --> 00:32:49,970
+مركّب في جسمي الميم والنون مقداره حركتين عندما
+
+363
+00:32:49,970 --> 00:32:59,100
+نقول فلمّا فكلمة الالغنى أو عندما نقول ان الله ان
+
+364
+00:32:59,100 --> 00:33:04,460
+الله الان لأنها تخرج من الخيشوم تكون هي صفات ايه
+
+365
+00:33:04,460 --> 00:33:12,100
+صفات الغنى طبعا الغنى طبعاهي يعني عبارة عن صوت غن
+
+366
+00:33:12,100 --> 00:33:17,280
+مركب في جسمي الميم والنون انتهينا يا أخوات من مخرج
+
+367
+00:33:17,280 --> 00:33:22,540
+الحروف كلها الخمس مخرج عامة والمخرج الفرعية بقى
+
+368
+00:33:22,540 --> 00:33:27,380
+علينا صفات الحروف والتي سوف نأخذها ان شاء الله في
+
+369
+00:33:27,380 --> 00:33:30,780
+المحاضرة القادمة بارك الله فيكم واجزاكم الله خيرا
+
+370
+00:33:30,780 --> 00:33:33,160
+و السلام عليكم ورحمة الله وبركاته
+
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/wTrE9XJVHuw.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/wTrE9XJVHuw.srt
new file mode 100644
index 0000000000000000000000000000000000000000..4b755148d40b7e463d4ebe1c72805ef5180fc628
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/wTrE9XJVHuw.srt
@@ -0,0 +1,2299 @@
+1
+00:00:00,000 --> 00:00:02,680
+موسيقى
+
+2
+00:00:12,220 --> 00:00:14,580
+السلام عليكم ورحمة الله وبركاته بسم الله الرحمن
+
+3
+00:00:14,580 --> 00:00:18,900
+الرحيم الحمد لله والصلاة والسلام على رسول الله وعلى 
+
+4
+00:00:18,900 --> 00:00:21,900
+آله وصحبه وسلم أخذنا يا أخوات في المحاضرة
+
+5
+00:00:21,900 --> 00:00:26,840
+الماضية أقسام الوقف الاختياري أخذنا الوقف التام و
+
+6
+00:00:26,840 --> 00:00:29,980
+الوقف الكافي والوقف الحسن هناخد إن شاء الله وال
+
+7
+00:00:29,980 --> 00:00:33,980
+وقف القبيح أقسام الوقف الاختياري الوقف التام من
+
+8
+00:00:33,980 --> 00:00:38,320
+يعرفنا الوقف التام يا بنات؟ ما هو الوقف التام؟ أن 
+
+9
+00:00:38,320 --> 00:00:42,640
+يقف القارئ على كلمة قرآنية تم المعنى عندها لا 
+
+10
+00:00:42,640 --> 00:00:47,420
+تتعلق بما بعدها لا لفظًا ولا معنى ممتاز طيب الوقف
+
+11
+00:00:47,420 --> 00:00:51,700
+الكافي؟ أن يقف القارئ.. نفس التعريف أن يقف القارئ 
+
+12
+00:00:51,700 --> 00:00:55,820
+على كلمة القرآنية تم المعنى عندها تتعلق بما بعدها 
+
+13
+00:00:55,820 --> 00:01:03,420
+في المعنى دون اللفظ ما هو رمز الوقف التام؟ قلأ ما
+
+14
+00:01:03,420 --> 00:01:08,760
+معنى قلأ؟ الوقف أولى يعني يجوز الوقف والواصل ولكن 
+
+15
+00:01:08,760 --> 00:01:16,260
+الوقف أولى طيب ما هو رمز الوقف الكافي جيم أو صلاة 
+
+16
+00:01:16,260 --> 00:01:22,860
+صلاة ما معناها؟ يعني الوصل أولى، يعني هي مقتبسة أو
+
+17
+00:01:22,860 --> 00:01:28,540
+منحوطة من جملة الوصل أولى، الوصل أولى أولى أه، و
+
+18
+00:01:28,540 --> 00:01:33,540
+الوصل يعني صلاة أو صادم، طيب ومعناها كذلك جيم، 
+
+19
+00:01:33,540 --> 00:01:36,760
+يعني في عندنا رمزين للوقف الكافي، جيم وصلاة، ولكن 
+
+20
+00:01:36,760 --> 00:01:41,640
+جيم أشد كفاية من صلاة اليوم إن شاء الله نحن بناخد 
+
+21
+00:01:41,640 --> 00:01:45,640
+الوقف الحسن والوقف الحسن هو أن يقف القارئ على كلمة 
+
+22
+00:01:45,640 --> 00:01:50,500
+قرآنية إن تم المعنى عندها تتعلق بما بعدها في اللفظ
+
+23
+00:01:50,500 --> 00:01:55,580
+والمعنى نحن قلنا أن الوقف التام لا تتعلق لا لفظًا 
+
+24
+00:01:55,580 --> 00:02:00,600
+ولا معنى بما بعدها الوقف الكافي تتعلق بما بعدها في 
+
+25
+00:02:00,600 --> 00:02:04,760
+المعنى دون اللفظ أما الوقف الحسن فتتعلق بما بعدها
+
+26
+00:02:04,760 --> 00:02:10,340
+في المعنى واللفظ إذا من يعرفنا الوقف الحسن؟ هو اللي 
+
+27
+00:02:10,340 --> 00:02:13,140
+وقف على التلقي فضل معنى في تذيبه لكنه اتعلق بما 
+
+28
+00:02:13,140 --> 00:02:17,510
+بعده صحيح أن يقدر يقرأ على كلام تم المعنى عنده
+
+29
+00:02:17,510 --> 00:02:22,330
+يتعلق بما بعده للفظ والمعنى وما هو حكم الوقف
+
+30
+00:02:22,330 --> 00:02:26,970
+الحسن في تفصيله لأن هناك وقف حسن يكون في منتصف
+
+31
+00:02:26,970 --> 00:02:31,790
+الآية وهناك وقف حسن يكون على رأس الآية إذا كان 
+
+32
+00:02:31,790 --> 00:02:36,910
+الوقف الحسن في منتصف الآية له حكم وهو يجوز أن نقف
+
+33
+00:02:36,910 --> 00:02:40,890
+عليه ولا يجوز الابتداء بما بعده لأنه يتعلق بما 
+
+34
+00:02:40,890 --> 00:02:45,410
+بعده في اللفظ والمعنى والأمثل على ذلك متعددًا مثال
+
+35
+00:02:45,410 --> 00:02:50,510
+ذلك أن نقف القارئ على قوله الحمد لله في قولنا يا
+
+36
+00:02:50,510 --> 00:02:57,050
+أخوات الحمد لله تم المعنى لكن مرتبطة ومتعلقة بما 
+
+37
+00:02:57,050 --> 00:03:02,370
+بعدها في اللفظ والمعنى الحمد لله رب العالمين لو 
+
+38
+00:03:02,370 --> 00:03:05,790
+واحد وقف على الحمد لله صحيح وقف على كلام تم المعنى
+
+39
+00:03:05,790 --> 00:03:12,080
+عنده لكن لأنه هو وقف حسن على منتصف الآية وتتعلق بما 
+
+40
+00:03:12,080 --> 00:03:16,160
+بعدها في المعنى واللفظ يجيزه أن نقف عليه ولا يجيزه 
+
+41
+00:03:16,160 --> 00:03:21,160
+الابتداء بما بعده بل يجب وصله بما بعده فنقول الحمد 
+
+42
+00:03:21,160 --> 00:03:26,360
+لله هنا وقفت وقفًا حسنًا لكن إذا أردت أن أبدأ لأقول
+
+43
+00:03:26,360 --> 00:03:31,080
+رب العالمين لأنه متعلق مع بعضهم البعض فأرجع كلمة 
+
+44
+00:03:31,080 --> 00:03:36,670
+أو كلمتين فأقول الحمد لله رب العالمين إذا هنا وصلنا 
+
+45
+00:03:36,670 --> 00:03:41,670
+الجملة أو الآية مع بعضها البعض إذا الوقف على الحمد 
+
+46
+00:03:41,670 --> 00:03:47,730
+لله يسمى وقف حسن تم المعنى عنده يتعلق بما بعده في
+
+47
+00:03:47,730 --> 00:03:51,710
+اللفظ والمعنى يجوز الوقف عليه ولا يجوز الابتداء
+
+48
+00:03:51,710 --> 00:03:56,070
+بما بعده بل يجب وصله بما بعده فإذا وقفت على الوقف 
+
+49
+00:03:56,070 --> 00:04:00,710
+الحسن في منتصف الآية يجوز فأقول الحمد لله لكن إذا 
+
+50
+00:04:00,710 --> 00:04:05,290
+أردت أن أكمل لا أقول رب العالمين بل أرجع قليلًا ثم 
+
+51
+00:04:05,290 --> 00:04:12,220
+أقول الحمد لله رب العالمين كذلك في المثال الثاني 
+
+52
+00:04:12,220 --> 00:04:16,540
+الحمد لله فاطر السماوات والأرض يجوز لنا أن نقف على
+
+53
+00:04:16,540 --> 00:04:21,000
+الحمد لله لأنه في منتصف الآية نقف وقفًا يسمى وقف
+
+54
+00:04:21,000 --> 00:04:24,800
+حسن في منتصف الآية يجوز الوقف عليه ولا يجوز
+
+55
+00:04:24,800 --> 00:04:29,820
+الابتداء بما بعده بل يجب وصله بما بعده فأقول الحمد
+
+56
+00:04:29,820 --> 00:04:34,600
+لله وقفت هنا إذا أردت أن أستنى في التلاوة لأقول
+
+57
+00:04:34,600 --> 00:04:38,840
+فاطر السماوات والأرض بالأقول الحمد لله فهذه 
+
+58
+00:04:38,840 --> 00:04:43,100
+السماوات والأرض كذلك بسم الله الرحمن الرحيم من 
+
+59
+00:04:43,100 --> 00:04:48,400
+قولنا بسم الله فمعناها تم المعنى عندها لكنها تتعلق 
+
+60
+00:04:48,400 --> 00:04:53,200
+بما بعدها لفظًا ومعنى يجوز الوقف عندها ولا يجوز 
+
+61
+00:04:53,200 --> 00:04:58,240
+وصلها بما بعدها لأنها تتعلق فيها لفظًا ولا يجوز 
+
+62
+00:04:58,240 --> 00:05:02,360
+الابتداء بما بعدها ولا يجب أن نصلها بما بعدها
+
+63
+00:05:02,360 --> 00:05:05,340
+فنقول بسم الله الرحمن الرحيم
+
+64
+00:05:09,000 --> 00:05:14,460
+المثال آخر عندنا مثلًا الوقف الحسن على رأس الآية 
+
+65
+00:05:14,460 --> 00:05:19,340
+نحن أخذنا يا أخوات الوقف الحسن في منتصف الآية الآن
+
+66
+00:05:19,340 --> 00:05:23,460
+هناخد الوقف الحسن على رأس الآية يعني عند الرقم
+
+67
+00:05:23,460 --> 00:05:27,160
+الآية وهو رأس الآية والوقف الحسن أو الوقف على رأس
+
+68
+00:05:27,160 --> 00:05:31,460
+الآية يا أخوات هو إيش؟ هو سنة يجب أن نقف وقفًا على 
+
+69
+00:05:31,460 --> 00:05:34,060
+رأس الآية طبعًا هذا سنة النبي عليه الصلاة والسلام
+
+70
+00:05:34,460 --> 00:05:40,000
+فيجوز الوقف الحسن على رأس الآية ويجوز الابتداء بما 
+
+71
+00:05:40,000 --> 00:05:43,860
+بعده عندما تكون في منتصف الآية يجوز أن نقف وقفًا 
+
+72
+00:05:43,860 --> 00:05:48,020
+حسنًا في منتصف الآية ولا يجوز الابتداء بما بعدها بل 
+
+73
+00:05:48,020 --> 00:05:51,140
+نصلها لكن إذا كان على رأس الآية يجوز أن نقف على
+
+74
+00:05:51,140 --> 00:05:56,200
+رأس الآية وقفًا حسنًا ويجب ويجوز الابتداء بما بعده 
+
+75
+00:05:56,200 --> 00:06:03,580
+مثلًا مثال ذلك نقول الحمد لله رب العالمين الحمد لله 
+
+76
+00:06:03,580 --> 00:06:09,260
+رب العالمين هنا رأس آية وهو متعلقة بالبعضها في 
+
+77
+00:06:09,260 --> 00:06:13,700
+اللفظ والمعنى ما معنى التعلق اللفظ يا أخوات؟
+
+78
+00:06:13,700 --> 00:06:18,340
+التعلق اللفظ إعرابي هنا لو قلنا مثلًا الحمد لله رب 
+
+79
+00:06:18,340 --> 00:06:23,720
+العالمين الرحمن الرحيم ما هو التعلق الإعرابي ما 
+
+80
+00:06:23,720 --> 00:06:27,800
+بين الرحمن الرحيم ورب العالمين؟ إيش الرحمن الرحيم 
+
+81
+00:06:27,800 --> 00:06:32,440
+بالنسبة لرب العالمين؟ صفتها يعني الحمد لله ما هي
+
+82
+00:06:32,440 --> 00:06:37,120
+صفة الله أو الحمد لله رب العالمين ما هو صفة رب 
+
+83
+00:06:37,120 --> 00:06:41,060
+العالمين أنه رحمن الرحيم كذلك بالنسبة للحمد لله
+
+84
+00:06:41,060 --> 00:06:46,080
+رب العالمين احنا قلنا إنه الحمد لله ماشي واصل
+
+85
+00:06:46,080 --> 00:06:50,380
+الآية وقف حسن لكن رب العالمين بالنسبة لله هو عبارة 
+
+86
+00:06:50,380 --> 00:06:54,930
+عن بدل لأن يجب أن نقول الحمد للرب العالمين الحمد
+
+87
+00:06:54,930 --> 00:06:59,550
+لله فعلاقة رب العالمين مع الله هو بدل وعلاقة 
+
+88
+00:06:59,550 --> 00:07:04,210
+الرحمن الرحيم مع رب العالمين هو صفة يجب أن نقف على 
+
+89
+00:07:04,210 --> 00:07:08,850
+الحمد لله رب العالمين وقفًا حسنًا على رأس الآية ويجب
+
+90
+00:07:08,850 --> 00:07:15,150
+أن نبدأ بالرحمن الرحيم لأنها بداية آية مع أن 
+
+91
+00:07:15,150 --> 00:07:19,910
+العلاقة ما بين الحمد لله رب العالمين والرحمن
+
+92
+00:07:19,910 --> 00:07:24,670
+الرحيم هي علاقة معنوية وعلاقة إعرابية فالرحمن 
+
+93
+00:07:24,670 --> 00:07:28,970
+الرحيم هو عبارة عن إيش صفة لرب العالمين والمعنى
+
+94
+00:07:28,970 --> 00:07:33,790
+كله متكامل من حيث المعنى إذ إن الآيات تثني على 
+
+95
+00:07:33,790 --> 00:07:36,890
+الله سبحانه وتعالى وتبين صفات المولى سبحانه وتعالى
+
+96
+00:07:36,890 --> 00:07:42,510
+بأنه هو الله رب العالمين الرحمن الرحيم مالك يوم 
+
+97
+00:07:42,510 --> 00:07:47,510
+الدين كذلك عندما نقف على الرحمن الرحيم علاقة الرحمن
+
+98
+00:07:47,510 --> 00:07:51,230
+الرحيم مع مالك يوم الدين النوع الوقف اللي هنا هو 
+
+99
+00:07:51,230 --> 00:07:55,950
+وقف حسن تم المعنى عنده لكنه يتعلق بما بعده في
+
+100
+00:07:55,950 --> 00:08:00,510
+اللفظ والمعنى ولما كان الرحمن الرحيم الوقف عليها
+
+101
+00:08:00,510 --> 00:08:04,310
+على رأس الآية هو الوقف على رأس الآية السنة يجوز 
+
+102
+00:08:04,310 --> 00:08:08,070
+الوقف عليه ويجوز الابتداء بما بعده فيجوز لنا أن 
+
+103
+00:08:08,070 --> 00:08:13,170
+نقول الرحمن الرحيم مالك يوم الدين لأنه برضه مالك
+
+104
+00:08:13,170 --> 00:08:17,430
+يوم الدين هو عبارة عن صفة لصفات متتالية لرب
+
+105
+00:08:17,430 --> 00:08:18,570
+العالمين
+
+106
+00:08:20,890 --> 00:08:24,810
+مثال آخر يا أخوات على الوقف الحسن إلا على رأس
+
+107
+00:08:24,810 --> 00:08:32,410
+الآية مثله ذلك يا أيها المزمل قم الليلة إلا قليلًا
+
+108
+00:08:32,410 --> 00:08:39,310
+أو قوله تعالى يا أيها المدثر قم فأنذر إذا هنا يا 
+
+109
+00:08:39,310 --> 00:08:43,170
+أيها المزمل هي عبارة عن رأس آية تم المعنى عندها 
+
+110
+00:08:43,170 --> 00:08:47,690
+تتعلق بما بعدها لفظًا ومعنى إذا الوقف على يا أيها 
+
+111
+00:08:47,690 --> 00:08:53,270
+المزمل هو عبارة عن وقف حسن ويجب أن نقف عليها وأن 
+
+112
+00:08:53,270 --> 00:08:57,330
+نبدأ بما بعدها فأقول يا أيها المزمل قم الليلة إلا 
+
+113
+00:08:57,330 --> 00:09:01,950
+قليلًا يا أيها المدثر قم فأنذر فهذا هو مثال على 
+
+114
+00:09:01,950 --> 00:09:09,250
+الوقف الحسن على رأس الآية نعم ما ده هي رأس آية من
+
+115
+00:09:09,250 --> 00:09:13,610
+السنة أن نقف لكن لو واحد قال يا أيها المزمل قم 
+
+116
+00:09:13,610 --> 00:09:18,950
+الليلة إلا قليلًا يجوز لكن نحن نقف على رأس الآية 
+
+117
+00:09:18,950 --> 00:09:22,530
+والوقف على رأس الآية سنة ولما كانت العلاقة ما بين
+
+118
+00:09:22,530 --> 00:09:26,390
+يا أيها المزمل قم الليلة إلا قليلًا علاقة إعرابية 
+
+119
+00:09:26,390 --> 00:09:30,030
+معنوية يعني متعلقة بما بعدها في اللفظ والمعنى
+
+120
+00:09:30,030 --> 00:09:34,510
+فالوقف هو عبارة عن وقف حسن يجوز أن نقف عليه ويجوز
+
+121
+00:09:34,510 --> 00:09:38,550
+الابتداء بما بعده لأنه على رأس آية لكن الوقف في
+
+122
+00:09:38,550 --> 00:09:43,010
+منتصف الآية ما هو حكمه يا أخوات؟ يجوز الوقف عليه
+
+123
+00:09:43,010 --> 00:09:47,450
+ولا يجوز الابتداء بما بعده بل يجب أن نصل الآية مع
+
+124
+00:09:47,450 --> 00:09:51,970
+بعضها البعض مثال آخر كذلك يا أخوات على الوقف الحسن
+
+125
+00:09:51,970 --> 00:09:58,770
+مثلًا وإن نشأ نغرقهم فلا صريخ لهم ولا هم يوقظون إلا
+
+126
+00:09:58,770 --> 00:10:05,250
+رحمة منا ومتاع إلى حين ولهم ينقذون رأس آية تم 
+
+127
+00:10:05,250 --> 00:10:09,830
+المعنى عندها تتعلقوا بما بعدها لفظًا ومعنى ما بعدها 
+
+128
+00:10:09,830 --> 00:10:13,850
+استثناء إلا رحمة منا ومتاع إلى حين إذا التعلق
+
+129
+00:10:13,850 --> 00:10:18,050
+إعرابي وتعلق معنى وفي الكلام كله متواصل فالوقف
+
+130
+00:10:18,050 --> 00:10:22,020
+عليها وقف حسن ولما كان الوقف الحسن على رأس الآية 
+
+131
+00:10:22,020 --> 00:10:28,320
+يجب أن نقف عليه ويجب أن نبدأ بما بعده وهذا هو مثال
+
+132
+00:10:28,320 --> 00:10:34,280
+على الوقف الحسن الوقف الحسن على رأس الآية يوهم 
+
+133
+00:10:34,280 --> 00:10:38,620
+معنى غير المعنى المراد في قوله مثلًا فويل للمصلين 
+
+134
+00:10:38,620 --> 00:10:42,820
+يعني في عندنا بعض الآيات أو آيتين مثلًا في القرآن
+
+135
+00:10:42,820 --> 00:10:49,010
+الكريم من ضمنها فويل للمصلين هي وقف حسن ولكن توهم
+
+136
+00:10:49,010 --> 00:10:52,770
+معنى غير المعنى المراد أو قد توهم معنى غير المعنى
+
+137
+00:10:52,770 --> 00:10:57,170
+المراد لذلك اختلف العلماء على الوقف على هذه الرأس
+
+138
+00:10:57,170 --> 00:11:01,250
+الآية اللي هو فويل المصلين منصورة المعون اختلف
+
+139
+00:11:01,250 --> 00:11:06,810
+عليه إلى ثلاثة أقوال مثلًا في قول تعالى فويل للمصلين
+
+140
+00:11:06,810 --> 00:11:13,090
+الذين هم عن صلاتهم ساهون في قوله فويل للمصلين ما
+
+141
+00:11:13,090 --> 00:11:18,170
+معنى الويل يا أخواتي؟ الويل هو واد في جهنم تستعيذ
+
+142
+00:11:18,170 --> 00:11:22,230
+منه جهنم في اليوم سبعين مرة، إذا هو عبارة عن الويل 
+
+143
+00:11:22,230 --> 00:11:27,570
+بمعنى العذاب للمصلين، لو تركتها كذا فقولنا فويل
+
+144
+00:11:27,570 --> 00:11:32,290
+للمصلين معناته العذاب للمصلين، لكن لو وصلناها بتكون
+
+145
+00:11:32,290 --> 00:11:35,470
+فويلوا للمصليين .. مين هم العطليين هؤلاء؟ فويلوا
+
+146
+00:11:35,470 --> 00:11:39,790
+للمصليين الذين هم عن صلاتهم ساهون يعني الذين يسفون 
+
+147
+00:11:39,790 --> 00:11:44,450
+عن الصلاة فيؤخرونها عن وقتها أو مثلا لا يصلونها و
+
+148
+00:11:44,450 --> 00:11:48,630
+يسفون عن الصلاوات فلا يصلون هؤلاء تتواعدهم الآيات
+
+149
+00:11:48,630 --> 00:11:53,410
+بالويل وهو واد في جهنم تستعيذ منه جهنم في اليوم 
+
+150
+00:11:53,410 --> 00:11:58,490
+سبعين مرة، فلما كان الوقف عليها يوهم معنى غير المعنى
+
+151
+00:11:58,490 --> 00:12:02,450
+المراد، لما واحد يقول فويل المصليين اختلف العلماء
+
+152
+00:12:02,450 --> 00:12:07,810
+على الوقف على قوله فويل المصليين إلى ثلاثة أقوال، ما
+
+153
+00:12:07,810 --> 00:12:12,090
+هي أقوال العلماء أو آراء العلماء في الوقف على 
+
+154
+00:12:12,090 --> 00:12:16,650
+المصليين من قوله فويل المصليين الذين عن صلاتهم 
+
+155
+00:12:16,650 --> 00:12:21,720
+ساهون؟ الرأي الأول يا أخوات هو لا يجب الوقف عليه 
+
+156
+00:12:21,720 --> 00:12:26,860
+إلا مضطرا ويجب وصله بما بعده، يعني المضطر مهما ما
+
+157
+00:12:26,860 --> 00:12:32,900
+هو الوقف الإضطراري، أن يقف القارئ على كلمة قرأنية لم 
+
+158
+00:12:32,900 --> 00:12:38,480
+يتم المعنى عندها بسبب ضرورة ألجأته لذلك، يعني كعطاس
+
+159
+00:12:38,480 --> 00:12:42,680
+أو سعال، يعني واحد مثلا وقف على فويل المصلين راح
+
+160
+00:12:42,680 --> 00:12:49,280
+عطس أو سعل أو انتهى نفسه أو نسيه، فهذا اسم الوقف
+
+161
+00:12:49,280 --> 00:12:55,380
+اللي هنا وقف اضطراري، يجوز الوقف عليه وإذا أراد 
+
+162
+00:12:55,380 --> 00:12:58,520
+بالنسبة للوقف الاضطراري أن يبدأ عليه أن يرجع كلمة 
+
+163
+00:12:58,520 --> 00:13:03,200
+أو كلمتين، لكن لو قلنا يا أخوات، ما هو حكم الوقف على 
+
+164
+00:13:03,200 --> 00:13:07,500
+قوله فويل المصلين؟ هل هو وقف قبيح ولا غير ذلك؟
+
+165
+00:13:13,410 --> 00:13:17,750
+أصلا هي مدام رأس آية فالوقف على رأس الآية سنة
+
+166
+00:13:17,750 --> 00:13:21,550
+ولذلك اللي أنا أقول وقف قبيح وهذا مكان للأسئلة
+
+167
+00:13:21,550 --> 00:13:25,630
+يعني كثير جدا من الأسئلة نقول لكم مثلا الوقف على 
+
+168
+00:13:25,630 --> 00:13:29,670
+قوله أو على كلمة المصليين من قوله تعالى فويل 
+
+169
+00:13:29,670 --> 00:13:33,350
+المصليين الذين هم عن صلاته مسهون وقف قبيح، صح ولا
+
+170
+00:13:33,350 --> 00:13:38,110
+غلط؟ هو خطأ لأنها ليس وقف قبيح وإنما هو وقف حسن 
+
+171
+00:13:38,110 --> 00:13:41,610
+لأنه لم يقف النبي عليه الصلاة والسلام وقفا قبيحا
+
+172
+00:13:41,610 --> 00:13:44,710
+لأن هذه وقف حافظ عليها النبي عليه الصلاة والسلام
+
+173
+00:13:44,710 --> 00:13:50,010
+إذا هي وقف حسن، تم المانع عنده لكنه يتعلق بما بعده 
+
+174
+00:13:50,010 --> 00:13:55,110
+لفظا ومعنى، فلما كانت الوقف عليها توهم معنى غير
+
+175
+00:13:55,110 --> 00:13:59,130
+المعنى المراد، اختلف العلماء على الوقف عليها إلى 
+
+176
+00:13:59,130 --> 00:14:04,130
+ثلاثة أقوال، الرأي الأول أنه لا يجوز الوقف على حولها 
+
+177
+00:14:04,130 --> 00:14:09,050
+أو على كلمة المصليين إلا إضطرارا ويجب وصله بما
+
+178
+00:14:09,050 --> 00:14:14,730
+بعده، يعني يجب أن يقول فويلوا للمصليين، ضاق النفس
+
+179
+00:14:14,730 --> 00:14:19,450
+ولا عطست ولا حصل أي شيء اضطراري، فويلوا للمصليين
+
+180
+00:14:19,450 --> 00:14:25,650
+سعلت، ثم علي أن أرجع فويلوا للمصليين الذين هم عن 
+
+181
+00:14:25,650 --> 00:14:31,390
+صلاتهم ساهون، أنا وقفت وقفا اضطراريا، فإذا أردت أن 
+
+182
+00:14:31,390 --> 00:14:36,170
+أبدأ، أرجع كلمة أو كلمتين ثم أستمر في المعنى أو في
+
+183
+00:14:36,170 --> 00:14:43,990
+القراءة، فهذا يسمى الوقف الاضطراري ويجب وصلها بما 
+
+184
+00:14:43,990 --> 00:14:50,470
+بعدها، وهذا هو الرأي الأول، الرأي الثاني هو يجب أن 
+
+185
+00:14:50,470 --> 00:14:53,880
+نقف عليها وقفا اختياريا، يعني بنفع اقول فويل
+
+186
+00:14:53,880 --> 00:14:58,680
+للمصليين وقفا اختياريا، ولكن لا يجب الابتداء بما 
+
+187
+00:14:58,680 --> 00:15:05,480
+بعده، بل يجب أن اصله بما بعده، فاقولها فويل للمصليين
+
+188
+00:15:06,760 --> 00:15:11,440
+وقفا اختياريا ثم ارجع و اقول فويل للمصليين الذين هم 
+
+189
+00:15:11,440 --> 00:15:16,800
+عن صلاتهم ساهون، ماذا فعلت؟ وقفت عليها وقفا
+
+190
+00:15:16,800 --> 00:15:21,100
+اختياريا، فلما أردت أن أستانف في التلاوة لا أقول
+
+191
+00:15:21,100 --> 00:15:25,540
+الذين هم عن صلاتهم ساهون، بل أرجع كلمة أو كلمتين 
+
+192
+00:15:25,540 --> 00:15:29,500
+حتى يستقيم المعنى، فكان هذا هو الرأي الأول، الثاني 
+
+193
+00:15:29,500 --> 00:15:32,300
+ما الفرق بين الرأي الأول والرأي الثاني يا بنات؟
+
+194
+00:15:33,790 --> 00:15:38,230
+الرأي الأول يقول
+
+195
+00:15:38,230 --> 00:15:42,430
+لا يجوز الوقف عليه إلا إضطراري، والرأي الثاني يجوز 
+
+196
+00:15:42,430 --> 00:15:47,390
+الوقف عليه اختياري، وكلاهما يجب وصله بما بعدهم
+
+197
+00:15:47,390 --> 00:15:52,090
+الرأي الثالث وهو الرأي المعتمد أنه يجوز الوقف عليه 
+
+198
+00:15:52,090 --> 00:15:57,990
+اختياريا ويجوز الابتداء بما بعده، ولكن الذي لا يجوز
+
+199
+00:15:57,990 --> 00:16:02,050
+هو قطع القراءة، يعني يجوز أن أقف عليه وأقول فويل
+
+200
+00:16:02,050 --> 00:16:09,530
+للمصليين الذين هم عن صلاتهم ساهون، أنا الآن وقفت
+
+201
+00:16:09,530 --> 00:16:15,590
+عليها وكملت الآية بما بعدها، ولكن الذي لا يجوز أن 
+
+202
+00:16:15,590 --> 00:16:19,450
+أقول مثلا في الصلاة أقرأ رأيت الذي يكذب بالدين
+
+203
+00:16:19,450 --> 00:16:23,750
+فذلك الذي يدعو اليتيم ولا يحض على طعم المسكين، فويل
+
+204
+00:16:23,750 --> 00:16:28,330
+للمصليين، الله أكبر أو روح تبكي، فهذا اسمه قطع
+
+205
+00:16:28,330 --> 00:16:31,990
+القراءة وهو الانتهاء من القراءة والانشغال عنها
+
+206
+00:16:31,990 --> 00:16:36,730
+بأمر آخر، انشغلت في الركوع، فمعنى أنه أقول لكم يا
+
+207
+00:16:36,730 --> 00:16:40,870
+مصليين اللي بقعدين بصلي ورايا وانا ركعت طبعا هذا 
+
+208
+00:16:40,870 --> 00:16:45,220
+معنى غير صحيح، إذا كان بدك تقطع القراءة، أو واحد يقرأ 
+
+209
+00:16:45,220 --> 00:16:49,440
+ويقول فويل للمصليين صدق الله العظيم والسلام عليكم 
+
+210
+00:16:49,440 --> 00:16:55,120
+ومشي، معناته أن الويل للمصليين الذي لا يجوز هو قطع
+
+211
+00:16:55,120 --> 00:17:01,220
+القراءة، والذي جائز يجوز أن نقف عليها ونستأنف بما 
+
+212
+00:17:01,220 --> 00:17:05,920
+بعدها، ولكن لا يجوز أن نقطع القراءة، يجوز أن أقول 
+
+213
+00:17:05,920 --> 00:17:13,440
+فويل للمصليين الذين هم عن صلاتهم ساهون، صحي فضل نعم
+
+214
+00:17:21,620 --> 00:17:29,160
+الرأي الثاني يجب الوقف عليه اختياريا ويجب وصله بما
+
+215
+00:17:29,160 --> 00:17:35,160
+بعدهم، يعني ارجع كلامي هنا في الرأي الثالث يجب 
+
+216
+00:17:35,160 --> 00:17:39,700
+الوقف عليه ويجب الابتداء بما بعده، يعني اقول فويله 
+
+217
+00:17:39,700 --> 00:17:45,950
+للمصليين في الرأي الثالث، الرأي الثالث، الفرق يا 
+
+218
+00:17:45,950 --> 00:17:49,370
+أخوات أن هنا لا يجوز أن أقول الذين هم عن صلاة
+
+219
+00:17:49,370 --> 00:17:54,270
+يمسون، لكن في الرأي الثالث يجوز أن أقول فويلوا
+
+220
+00:17:54,270 --> 00:17:58,250
+للمصليين، أنا وقفت عليه ويجوز الإبتداء بما بعده
+
+221
+00:17:58,250 --> 00:18:03,290
+فأقول الذين هم عن صلاة يمسون، الذي لا يجوز هو قطع 
+
+222
+00:18:03,290 --> 00:18:07,810
+القراءة عند المصليين، فأقول فويلوا للمصليين الله
+
+223
+00:18:07,810 --> 00:18:11,710
+أكبر أركع أو فويلوا للمصليين السلام عليكم ورحمة
+
+224
+00:18:11,710 --> 00:18:13,090
+الله وبركاته وخلصت القراءة 
+
+225
+00:18:16,300 --> 00:18:21,160
+لا يا أخواتي اللي على الصطاب برا يجوز الوقف عليه، و
+
+226
+00:18:21,160 --> 00:18:25,880
+يجوز الابتداء بما بعده، بل .. ولكن الذي لا يجوز قطع 
+
+227
+00:18:25,880 --> 00:18:29,260
+القراءة، أنا بالنسبة للي عندكم في الكتاب طبعا 
+
+228
+00:18:29,260 --> 00:18:32,600
+الراية الثانية هو الراية الثالثة، الراية الثانية
+
+229
+00:18:32,600 --> 00:18:35,540
+عندكم هو الراية الثالثة عندي، ولكن وضعتهم و ترتبتهم
+
+230
+00:18:35,540 --> 00:18:39,340
+عشان أسهل، يعني الأول لا يجوز الوقف عليه إلا مضطرا
+
+231
+00:18:39,340 --> 00:18:42,720
+ويجب وصله بما بعده، الراية الثانية يجوز الوقف عليه
+
+232
+00:18:42,720 --> 00:18:46,300
+اختياريا ولكن يجب وصله باللي بعده، الراية الثالثة 
+
+233
+00:18:46,300 --> 00:18:50,700
+يجوز الوقف عليه و يجوز الابتداء بما بعده، ولكن الذي 
+
+234
+00:18:50,700 --> 00:18:54,240
+لا يجوز هو قطع القراءة، هذا النقطة يا أخوات غالبا
+
+235
+00:18:54,240 --> 00:18:58,180
+ما تاتي في الامتحانات، اهتموا في هذه النقطة المهمة 
+
+236
+00:18:58,180 --> 00:19:02,680
+انتهينا يا أخوات من الوقف الحسن وهو القسم الثالث 
+
+237
+00:19:02,680 --> 00:19:06,880
+من أقسام الوقف الإختياري، طبعا في عندنا يا أخوات
+
+238
+00:19:06,880 --> 00:19:11,800
+تقسيم للوقف الإختياري، أقسام الوقف الإختياري وأقسام
+
+239
+00:19:11,800 --> 00:19:18,390
+للوقف العام، ما هي أقسام الوقف الإختياري؟ الاختياري 
+
+240
+00:19:18,390 --> 00:19:22,390
+الوقف التام والوقف الكافي والوقف الحسن والوقف 
+
+241
+00:19:22,390 --> 00:19:27,550
+القبيح، ما هي أقسام الوقف بشكل عام؟ الوقف الأول الشيء
+
+242
+00:19:27,550 --> 00:19:33,230
+الاضطراري، الوقف الاختياري، الوقف الانتظاري، أربعة 
+
+243
+00:19:33,230 --> 00:19:36,410
+الوقف الاختياري، والوقف الاختياري هو الذي ينقسم إلى
+
+244
+00:19:36,410 --> 00:19:40,390
+أربعة أقسام هو الوقف التام والوقف الكافي والوقف
+
+245
+00:19:40,390 --> 00:19:44,590
+الحسن والوقف القبيح، أخذنا ثلاثة أقسام منها وهو التام
+
+246
+00:19:44,590 --> 00:19:49,370
+والكافي والحسن، والآن سناخد القسم الرابع والأخير من 
+
+247
+00:19:49,370 --> 00:19:53,650
+أقسام الوقف الاختياري
+
+248
+00:19:53,650 --> 00:19:59,050
+وهو الوقف القبيح، من كلمة قبيح يعني أن وقفنا على 
+
+249
+00:19:59,050 --> 00:20:03,390
+كلمة مش مفهومة، أو أنها توهم معنى غير المعنى المراد
+
+250
+00:20:03,390 --> 00:20:08,590
+لذلك عرف العلماء الوقف القبيح بأنه الوقف على كلمة
+
+251
+00:20:08,590 --> 00:20:15,150
+قرآنية لم تفد معنى لشدة تعلقها بما بعدها لفظا 
+
+252
+00:20:15,150 --> 00:20:20,750
+ومعنى أو أنها توهم معنى غير المعنى المراد، يبقى أن 
+
+253
+00:20:20,750 --> 00:20:25,550
+يقف على كلمة قرآنية لم يتم المعنى عندها لشدة 
+
+254
+00:20:25,550 --> 00:20:31,050
+تعلقها بما بعدها لفظا ومعنى، أو أنها توهم معنى غير
+
+255
+00:20:31,050 --> 00:20:34,590
+المعنى المراد، مدام في أو يبقى في عندنا انقسام 
+
+256
+00:20:34,590 --> 00:20:39,970
+ينقسم الوقف القبيح إلى قسمين، وقف أنه يوهم معنى غير
+
+257
+00:20:39,970 --> 00:20:42,910
+المعنى المراد اللي هو القسم الثاني، والتاني لشدة
+
+258
+00:20:42,910 --> 00:20:48,150
+تعلقها بما بعدها لم يفهم المعنى، والأمثلة توضح ذلك
+
+259
+00:20:48,150 --> 00:20:54,230
+إذا من يعرف لنا الوقف القبيح هو فضله؟ هو اللي أقف 
+
+260
+00:20:54,230 --> 00:20:57,950
+على كلام لمثل معنى في كتابه بشكل تعلق بما بعد و
+
+261
+00:20:57,950 --> 00:21:04,510
+لفظه المعنى، ممتاز، أحسنتِ، أن يقف القارئ على كلام لم 
+
+262
+00:21:04,510 --> 00:21:09,630
+يفد معنى لشدة تعلقه بما بعدها لفظا ومعنى، أو لأنه
+
+263
+00:21:09,630 --> 00:21:14,130
+يوهم معنى غير المعنى المراد، وينقسم الوقف القبيح
+
+264
+00:21:14,130 --> 00:21:19,270
+إلى قسمين، القسم الأول هو أن يقف على كلام لم يفد
+
+265
+00:21:19,270 --> 00:21:23,630
+معنى لشدة تعلقه بما بعده لفظا ومعنى، كأن يقف على 
+
+266
+00:21:23,630 --> 00:21:28,730
+الفعل وخل الفعل ورا، أو المبتدأ دون الخبر، أو مثلا
+
+267
+00:21:28,730 --> 00:21:32,610
+يعني في كلام مرتبط مع بعضه البعض لم يفهم معنى 
+
+268
+00:21:32,610 --> 00:21:36,430
+الأمثل على ذلك متعددة، وناخد مثال سهل على صورة
+
+269
+00:21:36,430 --> 00:21:42,390
+الفاتحة مثلا عندنا الحمد لله رب العالمين، لو واحد 
+
+270
+00:21:42,390 --> 00:21:47,850
+وقف على الحمد، فهمتوا شيء؟ ماذا أفادت؟ لم تفيد
+
+271
+00:21:47,850 --> 00:21:53,450
+معنى، ما معنى الحمد؟ لذلك وقفت على كلمة قرأنية لم
+
+272
+00:21:53,450 --> 00:21:57,790
+تفيد معنى، ليش؟ لشدة تعلقها بما بعدها في اللفظ
+
+273
+00:21:57,790 --> 00:22:03,290
+والمعنى، لأن الحمد هي مبتدأ، و لله اللي هي جاره 
+
+274
+00:22:03,290 --> 00:22:07,810
+مجرور في محل رفع الخبر، لذلك مابنفع أقول الحمد،
+
+275
+00:22:07,810 --> 00:22:13,050
+بعدين لله، اللي لابد أن أقول الحمد لله رب العالمين
+
+276
+00:22:13,050 --> 00:22:17,250
+فالوقف على كلمة الحمد أخوات هنا معناته إيش؟ أن هذا 
+
+277
+00:22:17,250 --> 00:22:22,410
+وقف قبيح، لأنه وقف على كلمة قرأنية لم يتم المعنى
+
+278
+00:22:22,410 --> 00:22:27,810
+عندها لشدة تعلقها بما بعدها في اللفظ والمعنى، أو
+
+279
+00:22:27,810 --> 00:22:32,890
+مثل مثال آخر قوله هنا الوقف على كلمة الناس من قوله 
+
+280
+00:22:32,890 --> 00:22:40,790
+كان الناس، هي أصلا الآية كان الناس أمة واحدة فبعث 
+
+281
+00:22:40,790 --> 00:22:46,490
+الله النبيين مبشرين ومنذرين لو واحدة وقفت على كلمة 
+
+282
+00:22:46,490 --> 00:22:53,310
+كان كانة لحالها أو كان الناس مش مفهوم لم تؤدِ معناه
+
+283
+00:22:53,310 --> 00:22:57,770
+إذا وقفت على كلمة قرآنية لم يتم المعنى عندها لشدة 
+
+284
+00:22:57,770 --> 00:23:01,870
+تعلقها بما بعدها في اللفظ والمعنى وأي موضوع يا
+
+285
+00:23:01,870 --> 00:23:05,630
+أخوات يعني لو لو واحدة مثلا وضعت أصبعها على أي
+
+286
+00:23:05,630 --> 00:23:09,090
+كلمة في القرآن ووقفت عندها غالبا ما تكون هذه الوقف 
+
+287
+00:23:09,090 --> 00:23:14,440
+اللي عليها في القرآن لم تفتِ معنى لأن الوقفات يجب أن
+
+288
+00:23:14,440 --> 00:23:18,620
+تتبع المعنى بس بعد ما نقف يعني تم المعنى فبنقف
+
+289
+00:23:18,620 --> 00:23:23,640
+عليها لذلك الأمثلة على الوقف القبيح كثير جدا ولذلك
+
+290
+00:23:23,640 --> 00:23:27,900
+لا يوجد لها رمز معين باستمرار يوضع على كل وقف قبيح
+
+291
+00:23:27,900 --> 00:23:33,180
+لأنه لو أردنا أن نضع على كل وقف قبيح رمز معناته 
+
+292
+00:23:33,180 --> 00:23:37,880
+أنه كل كلمة هنحط عليها لا لا لا إنما في مواضع معينة
+
+293
+00:23:37,880 --> 00:23:42,960
+توهم معنى غير المعنى المراد هذا لذلك بنضع عليها 
+
+294
+00:23:42,960 --> 00:23:47,240
+رمز لكن الوقف القبيح كثير جدا في القرآن إذا وقفنا
+
+295
+00:23:47,240 --> 00:23:51,380
+على كلمة لم تفد معنى لذلك لابد أن ينتهي المبتدأ
+
+296
+00:23:51,380 --> 00:23:55,560
+والخبر الفعل والفاعل والمفعول بيكون متواصلة مع
+
+297
+00:23:55,560 --> 00:24:02,740
+بعضها البعض هنا مثلا كان الناس أمة واحدة فبعث الله 
+
+298
+00:24:02,740 --> 00:24:07,700
+النبيين مبشرين ومنذرين لو وقف القارئ على كان 
+
+299
+00:24:07,700 --> 00:24:12,440
+لحالها لم تفيد معناه لو وقف القارئ على كان الناس 
+
+300
+00:24:12,440 --> 00:24:16,720
+كان الناس مالهم لم تفيد معناه إذا الوقف على الناس 
+
+301
+00:24:16,720 --> 00:24:23,740
+يسمى وقف قبيح في عليه رمز لا ما فيش عليه رمز لكن هو 
+
+302
+00:24:23,740 --> 00:24:29,340
+وقف قبيح لأن كل كلمة لم تفيد معنى لأنها مرتبطة مع
+
+303
+00:24:29,340 --> 00:24:34,680
+معمادها في اللفظ والمعنى يسمى وقف قبيح كذلك مثال 
+
+304
+00:24:34,680 --> 00:24:42,360
+آخر هنا ألا يظن أولئك أنهم مبعوثون أين الوقف
+
+305
+00:24:42,360 --> 00:24:49,350
+القبيح هنا؟ لو واحدة وقفت عن كلمة ألا أفدت معنى؟ لو
+
+306
+00:24:49,350 --> 00:24:53,890
+وقفت عند كلمة ألا يظنوا في معنى؟ ليس هناك معنى لو 
+
+307
+00:24:53,890 --> 00:24:59,210
+جاءت ألا يظن أولئك برضه لم توفد معنى لابد أن يكون 
+
+308
+00:24:59,210 --> 00:25:04,090
+الكلام كامل إذا لو واحدة وقفت على كلمة ألا أو يظن
+
+309
+00:25:04,090 --> 00:25:08,530
+أو أولئك معناته أن حتى الآن لم توفد معنى أو ألا
+
+310
+00:25:08,530 --> 00:25:13,530
+يظن أولئك أنهم فهمتش إيه؟ يعني الأربع وقفات هنا 
+
+311
+00:25:13,530 --> 00:25:17,810
+خطأ، يعني تسمى وقف قبيح، لابد أن تكمل الجملة فتقول
+
+312
+00:25:17,810 --> 00:25:24,690
+ألا يظن أولئك أنهم مبعوثون، الآن اكتمل المعنى
+
+313
+00:25:25,310 --> 00:25:29,850
+مفهوم؟ إذا وقف على كلمة قرآنية لم يتم المعنى عندها
+
+314
+00:25:29,850 --> 00:25:34,150
+لشدة تعلوقها بما بعدها في اللفظ والمعنى يسمى هذا 
+
+315
+00:25:34,150 --> 00:25:39,390
+الكلام وقف أو قبيح نشوف كذلك مثال آخر من يقرأ
+
+316
+00:25:39,390 --> 00:25:45,390
+الآية ويقول أين يقع الوقف القبيح؟ أه ميعرفه؟ إن
+
+317
+00:25:45,390 --> 00:25:54,150
+هذا أخي .. فضلي طيب
+
+318
+00:25:54,150 --> 00:26:01,060
+و ليه ..لو واحدة وقفت عند كلمة إن .. قبيح إن هذا
+
+319
+00:26:01,060 --> 00:26:07,440
+.. قبيح إن هذا أخي له .. برضه قبيح إن هذا أخي له
+
+320
+00:26:07,440 --> 00:26:11,540
+تسع و تسعون .. برضه قبيح لأنه لم يفد معنى لشدة
+
+321
+00:26:11,540 --> 00:26:17,580
+تعلقه بما بعده في اللفظ و المعنى لو قال إن هذا أخي
+
+322
+00:26:17,580 --> 00:26:24,210
+له تسع و تسعون .. تسع و تسعون إيش؟ تفاحة، نعجة،
+
+323
+00:26:24,210 --> 00:26:29,110
+كذا، مش معروف. لما اكتملت كان نعجة نعجة ماشي. نعجة
+
+324
+00:26:29,110 --> 00:26:34,110
+تولية نعجة واحدة اكتمل المعنى. هذه يا أخوات هو
+
+325
+00:26:34,110 --> 00:26:38,850
+الوقف القبيح لأنه وقفنا على كلمة قرآنية لم تفد
+
+326
+00:26:38,850 --> 00:26:43,110
+معنى لشدة تعلقها بما بعدها في اللفظ والمعنى. يجوز 
+
+327
+00:26:43,110 --> 00:26:47,020
+الوقف عليها وقفا اضطراريا. بنفع نقف اضطراريا؟ يعني
+
+328
+00:26:47,020 --> 00:26:53,000
+لو واحد قال إن هذا أخي له تسع وتسعون أتشي عطس أو 
+
+329
+00:26:53,000 --> 00:26:59,620
+مثلا سعل أو انتهى نفسه أو نسي أو بكى، ماذا يفعل؟
+
+330
+00:26:59,620 --> 00:27:03,920
+يقف وقفا اضطراريا وهذا جائز حتى وإن كان الوقف قبيل 
+
+331
+00:27:04,200 --> 00:27:08,360
+لكنه يجب عليه أن يرجع كلمة أو كلمتين حتى يستقيم 
+
+332
+00:27:08,360 --> 00:27:13,800
+المعنى فيقول إن هذا أخي له تسع وتسعون نعجة وليه
+
+333
+00:27:13,800 --> 00:27:19,500
+نعجة واحدة يكمل الكلام بيكون الكلام أتم وأصلح
+
+334
+00:27:19,500 --> 00:27:25,100
+قراءته هذا القسم الأول القسم الثاني من أقسام الوقف
+
+335
+00:27:25,100 --> 00:27:29,220
+القبيح وهو أن يقف على كلام يوهم معنى غير المعنى 
+
+336
+00:27:29,220 --> 00:27:37,160
+المراد مثال ذلك مثلا إن الله لا يستحي أي ضرب مثلا 
+
+337
+00:27:37,160 --> 00:27:42,420
+ما بعوضة فما فوقها لو وقف القارئ على إن الله لا
+
+338
+00:27:42,420 --> 00:27:49,100
+يستحي أفادت معنى القبيح لأنه أوهم معنى غير المعنى
+
+339
+00:27:49,100 --> 00:27:53,240
+المراد فالله سبحانه وتعالى الحياء وشعبته من 
+
+340
+00:27:53,240 --> 00:27:57,400
+الإيمان والله عز وجل الحيي لذلك لا يجوز أن نقول إن
+
+341
+00:27:57,400 --> 00:28:03,780
+الله لا يستحيى إنما نكملها فالوقف عليها وقف قبيح لو
+
+342
+00:28:03,780 --> 00:28:08,600
+وقف عليها وقفا اضطراريا يجوز من وقف الاضطراري لكنه
+
+343
+00:28:08,600 --> 00:28:14,160
+يجب عليه أن يرجع فيقول إن الله لا يستحي أن يضرب 
+
+344
+00:28:14,160 --> 00:28:21,160
+مثلا بعوضة فما فوقها يعني يكمل الكلام مثال آخر على 
+
+345
+00:28:21,160 --> 00:28:27,520
+الوقف القبيح لأنه لم يفد معنى غير المعنى المراد هو
+
+346
+00:28:27,520 --> 00:28:32,600
+قوله يَا أَيُّهَا الَّذِينَ آمَنُوا لَا تَقْرَبُوا 
+
+347
+00:28:32,600 --> 00:28:36,080
+الصَّلَاةَ وَأَنْتُمْ سُكَارَىٰ حَتَّىٰ تَعْلَمُوا 
+
+348
+00:28:36,080 --> 00:28:41,100
+مَا تَقُولُونَ أين ممكن يقف القارئ ويؤدّي معنى قبيح؟
+
+349
+00:28:42,580 --> 00:28:46,460
+لو قال يا أيها الذين آمنوا لا تقربوا الصلاة يعني 
+
+350
+00:28:46,460 --> 00:28:50,040
+فيها نهي عن الاقتراب من الصلاة طبعا الاقتراب من 
+
+351
+00:28:50,040 --> 00:28:54,660
+الصلاة يمكن أبلغ من الصلاة لو قال لا تقربوا الصلاة 
+
+352
+00:28:54,660 --> 00:28:58,600
+أو لا تصلوا معنى لا تصلوا لكن لا تقربوا الصلاة
+
+353
+00:28:58,600 --> 00:29:01,300
+يعني حتى الوضوء والجامع اللي في الطريق ما تروحش
+
+354
+00:29:01,300 --> 00:29:04,830
+عليه ولا تجرب منه يعني كل طريق تؤدي إلى الصلاة زي 
+
+355
+00:29:04,830 --> 00:29:08,750
+مثلا و لا تقربوا الزنا يعني كل طريقة تؤدي لزنا من 
+
+356
+00:29:08,750 --> 00:29:16,410
+الخلوة و التبرج و كل مقدمات الزنا لا تقربها فهنا 
+
+357
+00:29:16,410 --> 00:29:19,550
+ربنا سبحانه وتعالى يقول يا أيها الذين آمنوا لا
+
+358
+00:29:19,550 --> 00:29:24,250
+تقربوا الصلاة وأنتم سكارى حتى تعلموا ما تقولونه
+
+359
+00:29:24,250 --> 00:29:27,690
+إذا لو وقفت عند كلمة لا تقربوا الصلاة بختل المعنى
+
+360
+00:29:27,690 --> 00:29:31,310
+توهم معنى غير المعنى المراد لذلك الوقف عليها يسمى
+
+361
+00:29:31,310 --> 00:29:37,570
+وقف قبيح مثال آخر على الوقف القبيح لأنه يوهم معنى
+
+362
+00:29:37,570 --> 00:29:42,610
+غير المعنى المراد هو كقوله تعالى وما أرسلنا من 
+
+363
+00:29:42,610 --> 00:29:48,290
+رسول إلا ليطاع بإذن الله لو قالت القارئة وما
+
+364
+00:29:48,290 --> 00:29:53,210
+أرسلنا من رسول يعني الله سبحانه وتعالى لم يرسل أي 
+
+365
+00:29:53,210 --> 00:29:57,750
+رسول إذا أفدت معنى غير المعنى المراد الله سبحانه
+
+366
+00:29:57,750 --> 00:30:02,130
+وتعالى أرسل رسوله لكن لو وقف عليها وما أرسلنا من
+
+367
+00:30:02,130 --> 00:30:05,230
+الرسول، معناته أن الله لم يرسل أي رسول، لذا لو 
+
+368
+00:30:05,230 --> 00:30:09,190
+الوقف عليه يسمى وقف قبيح لأنه يوهب معنى غير المعنى 
+
+369
+00:30:09,190 --> 00:30:13,530
+المراد، طيب لو واحد وقف وقفا اضطراريا، ماذا يفعل؟
+
+370
+00:30:13,530 --> 00:30:17,050
+يرجع كلمة أو كلمتين ثم يستمر في التلاوة، ماذا لو
+
+371
+00:30:17,050 --> 00:30:21,540
+قال وما أرسلنا من الرسول وانتهى نفسه؟ يرجع وما 
+
+372
+00:30:21,540 --> 00:30:26,680
+أرسلنا من رسول إلا ليطاع بإذن الله حتى يتم المعنى
+
+373
+00:30:26,680 --> 00:30:30,760
+مع بعضه البعض مثال آخر أيضا على الوقف القبيح لأنه 
+
+374
+00:30:30,760 --> 00:30:37,440
+يوهم معنى غير المعنى المراد وما من دابة في الأرض
+
+375
+00:30:37,440 --> 00:30:44,060
+ولا طائر يطير بجناحه لو وقف القارئ عند كلمة ولا 
+
+376
+00:30:44,060 --> 00:30:48,580
+طائر يطير بجناحه يعني لا يوجد طائر يطير بجناحه كيف 
+
+377
+00:30:48,580 --> 00:30:54,570
+الطائر يطير؟ أوهم معنى غير المعنى المراد لذلك يجب
+
+378
+00:30:54,570 --> 00:31:02,810
+أن يستمر في تلاوته ويقول وما من دابة في الأرض ولا 
+
+379
+00:31:02,810 --> 00:31:09,310
+طائر يطير بجناحيه إلا أمم أمثلكم لابد أن يكمم
+
+380
+00:31:09,310 --> 00:31:15,510
+المعنى ممكن ينتهي النفس بس يرجع أقل ولا طائرولا
+
+381
+00:31:15,510 --> 00:31:21,130
+طائر يطير بجناحيه إلا أمم أمثلكم على أساس تتم
+
+382
+00:31:21,130 --> 00:31:24,550
+المعنى مع بعضها البعض. آخر مثال عندنا بالنسبة
+
+383
+00:31:24,550 --> 00:31:28,830
+للوقف القبيح هو الوقف على الظالمين في قول تعالى 
+
+384
+00:31:28,830 --> 00:31:35,550
+يَدْخُلُ مَنْ يَشَاءُ فِي رَحْمَتِهِ وَالظَّالِمِينَ طبعا، لو وقف عند 
+
+385
+00:31:35,550 --> 00:31:40,330
+كلمة والظالمين، معناته أن الظالمين مشمولين في رحمة
+
+386
+00:31:40,330 --> 00:31:46,710
+الله عز وجل، لذلك يقول يدخلون من يشاء في رحمته
+
+387
+00:31:46,710 --> 00:31:52,590
+والظالمين، أَعَدَّ لَهُمْ عَذَابًا أَلِيمًا الظالمين أعدّ لهم
+
+388
+00:31:52,590 --> 00:31:54,790
+عذابًا أليمًا، لكن يدخلون ما يشاء في رحمته من
+
+389
+00:31:54,790 --> 00:32:00,530
+المؤمنين، فالوقف على الظالمين يوهم معنى غير المعنى
+
+390
+00:32:00,530 --> 00:32:06,370
+المراد. طبعا حكم الوقف على هذا والوقف الثاني،
+
+391
+00:32:06,370 --> 00:32:12,170
+القبيح، لا يجوز الوقف عليه إلا اضطرارا، وإذا
+
+392
+00:32:12,170 --> 00:32:16,170
+وقفنا عليه اضطرارا، يجب أن نرجع كلمة أو كلمتين
+
+393
+00:32:16,170 --> 00:32:21,550
+حتى يستقيم المعنى، ثم نستأنف التلاوة. ما هو يا أخوات
+
+394
+00:32:21,550 --> 00:32:26,730
+رمز الوقف القبيح؟ طبعا احنا قلنا أن أي موقف لا
+
+395
+00:32:26,730 --> 00:32:32,390
+يوقف عليه لأنه لم يفد المعنى يسمى وقف قبيح، لكن
+
+396
+00:32:32,390 --> 00:32:36,470
+هناك مواضع معينة زي مثلا ولا طائر يطير بجناحيه، لا
+
+397
+00:32:36,470 --> 00:32:41,630
+تقربوا الصلاة، فمن لاجي فوق لا تقربوا الصلاة
+
+398
+00:32:41,630 --> 00:32:46,630
+معناها لا ومعنى لأنه لا تقف على هذا المكان بل يجب
+
+399
+00:32:46,630 --> 00:32:52,490
+واصله لذلك الوقف القبيح الذي يوهم معنى غير معنى 
+
+400
+00:32:52,490 --> 00:32:57,190
+المراد نضع له لا لكن الوقف القبيح لأنه لم يتم 
+
+401
+00:32:57,190 --> 00:33:01,070
+المعنى عنده هذا موجود كثير جدا في القرآن لكن الذي 
+
+402
+00:33:01,070 --> 00:33:05,930
+يوهم معنى غير معنى المراد هو قليل ويضع عليه لفظة
+
+403
+00:33:05,930 --> 00:33:13,680
+لا إذا ما هو رمز الوقف القبيح؟ يرمز له بوقف لا كهذه
+
+404
+00:33:13,680 --> 00:33:17,640
+بمعنى لا تقف لا تقف على هذا الموضع لأنك لو وقف 
+
+405
+00:33:17,640 --> 00:33:22,740
+مثلا يا أيها الذين آمنوا لا تقربوا الصلاة ولا طائر
+
+406
+00:33:22,740 --> 00:33:28,140
+يطير بجناحيه الوقف عليها يسمى وقف قبيح لأنه يوهم
+
+407
+00:33:28,140 --> 00:33:33,780
+معنى غير المعنى المراد وقد يرمز أيضا برمز لا للوقف 
+
+408
+00:33:33,780 --> 00:33:40,260
+الحسن بمعنى لا تبتدئ بما بعده مثل ذلك فوين للمصلين
+
+409
+00:33:40,260 --> 00:33:44,680
+أو موضوع آخر يعني فوين .. معناته أنه لو بدأت بما
+
+410
+00:33:44,680 --> 00:33:49,840
+بعده يوهم معنى غير المعنى المراد كذلك قد يكون رمز
+
+411
+00:33:49,840 --> 00:33:55,740
+لا على رأس الآية على رأس آية على وقف حسن ومعناه لا
+
+412
+00:33:55,740 --> 00:34:00,960
+تقطع القراءة مثل هنا فوين للمصلين معناته وقف حسن
+
+413
+00:34:01,280 --> 00:34:06,120
+ولكن تعني هذه أن لا تقطع القراءة يجب عليك أن تخاف
+
+414
+00:34:06,120 --> 00:34:12,380
+تقول فوين للمصلين فوق المصلين حطين كلمة لا أو رمز 
+
+415
+00:34:12,380 --> 00:34:17,940
+لا الذين هم عن صلاتهم ساهون هي وقف حسن لكن الموضوع 
+
+416
+00:34:17,940 --> 00:34:22,920
+فوقه لامعناته أن لا تقطع القراءة على هذا الموضوع، 
+
+417
+00:34:22,920 --> 00:34:27,720
+لأن لو قلنا فوين للمصلين؟ معناته أننا نتواعد
+
+418
+00:34:27,720 --> 00:34:34,250
+المصلين بالوادي الذي هو في جهنم طيب في المصحف يا
+
+419
+00:34:34,250 --> 00:34:38,370
+أخوات في علامات معينة ورموز إحنا أخذناها في الوقف
+
+420
+00:34:38,370 --> 00:34:41,710
+التام والكافي والحسن والقبيح اللي هي كويس لو 
+
+421
+00:34:41,710 --> 00:34:46,230
+راجعناها بشكل سريع أول شيء الرمز ميم ال ميم
+
+422
+00:34:46,230 --> 00:34:52,830
+الأفقية هذه ترمز إلى أي نوع الوقف اللازم الوقف 
+
+423
+00:34:52,830 --> 00:34:57,030
+اللازم هو نفسه الوقف التام ولكن إذا وصلت اختل
+
+424
+00:34:57,030 --> 00:35:01,270
+المعنى فالوقف اللازم من يعرف أنه الوقف اللازم؟ هو
+
+425
+00:35:01,270 --> 00:35:05,490
+أن يقف القارئ على كلمة قرأنية تم المانع عندها لا
+
+426
+00:35:05,490 --> 00:35:11,590
+تتعلق بما بعدها لا لفظ ولا معنى ولكن إذا وصلت اختل
+
+427
+00:35:11,590 --> 00:35:15,710
+المعنى إذا لازم تقف على هذه الكلمة عندنا مثال على 
+
+428
+00:35:15,710 --> 00:35:22,800
+ذلك مثلا فلا يحزن كقولهم إِنَّا نَعْلَمُ مَا
+
+429
+00:35:22,800 --> 00:35:30,960
+يُسِرُونَ وَمَا يُعلنُونَ الآن في عندنا قولهم ميم
+
+430
+00:35:30,960 --> 00:35:35,400
+ومعنى هذه الميم أن الوقف اللي هنا وقف لازم يجب أن
+
+431
+00:35:35,400 --> 00:35:41,980
+تقف لأنك لو وصلت إيه باختلاف المعنى؟ لو قلت مثلا
+
+432
+00:35:41,980 --> 00:35:47,460
+فلا يحزنون كقولهم إِنَّا نَعْلَمُ مَا يُسِرُونَ
+
+433
+00:35:47,460 --> 00:35:53,020
+وَمَا يُعلنُونَ ماذا يفيد؟ إنه لا تحزن يا محمد على
+
+434
+00:35:53,020 --> 00:35:56,600
+الكفار الذين قالوا إننا نعلم ما يسرون و ما يعلنون
+
+435
+00:35:56,600 --> 00:36:00,460
+بكل إننا نعلم ما يسرون و ما يعلنون من كلام الكفار
+
+436
+00:36:01,800 --> 00:36:07,360
+ولكن هذا غير المراد، مش المراد المراد هو لا تحزن يا محمد
+
+437
+00:36:07,360 --> 00:36:11,240
+فلا يحزنك قولهم لا تحزن يا محمد على أن الكفار 
+
+438
+00:36:11,240 --> 00:36:16,260
+قالوا عنك ساحر أو شاعر أو كاهن أو مجنون أو شطبوك
+
+439
+00:36:16,260 --> 00:36:20,940
+أو سبوك أو اعترضوك لا تحزن على أقوالهم الله عز وجل
+
+440
+00:36:20,940 --> 00:36:25,400
+سوف يحاسبهم لأن الله يعلم ما يسرون و ما يعلنون إذا
+
+441
+00:36:25,400 --> 00:36:29,740
+قوله يا أخوات إننا نعلم ما يسرون و ما يعلنون كلام
+
+442
+00:36:29,740 --> 00:36:33,780
+مين؟ كلام ربنا لكن لو وصلناها بيصير كلام مين؟ كلام 
+
+443
+00:36:33,780 --> 00:36:40,680
+الكفار عشان هيك يوضع فوق قولهم ميم على أساس أن هذه
+
+444
+00:36:40,680 --> 00:36:47,770
+عبارة عن وقف لازم فنقول فلا يهزنك قوله، نقف ثم نقول 
+
+445
+00:36:47,770 --> 00:36:53,110
+إننا نعلم ما يسرون و ما يعلنون من الذي يعلم الله
+
+446
+00:36:53,110 --> 00:36:57,070
+سبحانه وتعالى هذا الرمز الأول وهو رمز ال ميم 
+
+447
+00:36:57,070 --> 00:37:03,510
+الأفقية في عندنا ميم بدنبة هذا اللي هي الأنبياء أو
+
+448
+00:37:03,510 --> 00:37:08,730
+من بعدهم بيصير إيش الأنبياء أو من بعدهم حطوا رمز
+
+449
+00:37:08,730 --> 00:37:12,470
+ميم بدنبة صغيرة دلالة على أنه هنا في عندنا إقلاب
+
+450
+00:37:12,470 --> 00:37:17,100
+تقلب النون الساكنة إلى ميم مخفى الرمز الثاني يا 
+
+451
+00:37:17,100 --> 00:37:21,500
+أخوات هو رمز قلة واخذناها لرمز قلة رمز قلة ما 
+
+452
+00:37:21,500 --> 00:37:28,020
+معناها؟ رمز للوقف التام ومعناها الوقف أولى الوقف
+
+453
+00:37:28,020 --> 00:37:32,440
+أولى من الوصل يعني يجب الوقف و الوصل ولكن الوقف
+
+454
+00:37:32,440 --> 00:37:38,440
+أولى في عندنا رمز جيم ماذا تعني جيم؟ جواز الوجهين
+
+455
+00:37:38,440 --> 00:37:45,960
+جواز الوقف وجواز الوصل في عندنا رمز صلاة صلاة من
+
+456
+00:37:45,960 --> 00:37:49,980
+الواصل أولى يعني نص يجيزه الواصل و يجيزه الوقف 
+
+457
+00:37:49,980 --> 00:37:54,900
+ولكن الواصل أولى وال جيم وال ميم علامتين لأي نوع
+
+458
+00:37:54,900 --> 00:38:00,900
+من أنواع الوقف الكافي ولا التام؟ الوقف الكافي الجيم
+
+459
+00:38:00,900 --> 00:38:07,900
+والصلاة رمزين للوقف الكافي لكن جيم أشد كفاية من
+
+460
+00:38:07,900 --> 00:38:15,380
+صلاة أما قلة فهو عبارة عن رمز للوقف التام في عندنا
+
+461
+00:38:15,380 --> 00:38:19,940
+مثل ما قلنا بعرضه رمز لا وقلنا إنه رمز لا يعد أيضا
+
+462
+00:38:19,940 --> 00:38:25,060
+للوقف القبيح وكذلك للوقف الحسن على رأس الآية بمعنى
+
+463
+00:38:25,060 --> 00:38:29,040
+إنه لا تقطع القراءة والوقف القبيح إذا أوهمت معنى
+
+464
+00:38:29,040 --> 00:38:34,620
+غير المعنى المراد وذكرنا ذلك مثال ذلك ولو ترى إذ
+
+465
+00:38:34,620 --> 00:38:41,620
+يتوفى الذين كفروا هنا الوقف اللي هنا بحط لك لا، 
+
+466
+00:38:41,620 --> 00:38:47,680
+يعني لا تقف على هذا الموضوع لأن
+
+467
+00:38:47,680 --> 00:38:52,340
+لو بدأنا بما بعده بيصير الملائكة يضربون وجوههم
+
+468
+00:38:52,340 --> 00:38:56,080
+وأدبارهم بيصير الملائكة هم أنفسهم يضربون أنفسهم 
+
+469
+00:38:56,080 --> 00:39:00,960
+وجوههم وأدبارهم لذلك مش هذا هو المراد المراد أن 
+
+470
+00:39:00,960 --> 00:39:06,420
+الملائكة يضربون وجوه الذين كفروا وأدبارهم لكن لو
+
+471
+00:39:06,420 --> 00:39:12,480
+وقفنا عند قوله ولو ترى إذ يتوفى الذين كفروا بعدين
+
+472
+00:39:12,480 --> 00:39:17,400
+قلنا الملائكة يضربون وجههم وأدبارهم بتوهم معنى غير
+
+473
+00:39:17,400 --> 00:39:21,780
+المعنى المراد لذلك يوضع عليها رمز إيه؟ رمز لا
+
+474
+00:39:21,780 --> 00:39:26,960
+بمعنى لا تقف على هذا الموضع في عندنا أيضًا رمز
+
+475
+00:39:26,960 --> 00:39:34,200
+أخوات وهو الرمز الثلاثة على شكل مثلث وهذا يسمى وقف
+
+476
+00:39:34,200 --> 00:39:38,580
+التعانق ووقف التعانق معناته لو وقفت على واحدة لا
+
+477
+00:39:38,580 --> 00:39:42,460
+تقف على الثانية إما أن تقف على الأولى وإما أن تقف
+
+478
+00:39:42,460 --> 00:39:49,260
+على الثانية مثل ذلك ذلك الكتاب لا ريب بعدين فيه 
+
+479
+00:39:49,260 --> 00:39:54,440
+كمان تلات مجرم هدى للمتقين لكن ما بنفع نقول ذلك 
+
+480
+00:39:54,440 --> 00:40:00,120
+الكتاب لا ريب فيه هدى للمتقين يام نقف على ذلك
+
+481
+00:40:00,120 --> 00:40:05,360
+الكتاب لا ريب وإما أن نقف على ذلك الكتاب لا ريب
+
+482
+00:40:05,360 --> 00:40:09,720
+فيه ونبدأ من قول هدى للمتقين وإما أن نصلها كلها مع 
+
+483
+00:40:09,720 --> 00:40:14,220
+بعضها لبعض فنقول ذلك الكتاب لا ريب فيه هدى للمتقين
+
+484
+00:40:14,810 --> 00:40:20,870
+إذا نقول ذلك الكتاب ولا ريب فيه هدى للمتقين أو
+
+485
+00:40:20,870 --> 00:40:26,790
+نقول ذلك الكتاب ولا ريب فيه هدى للمتقين لأن كل
+
+486
+00:40:26,790 --> 00:40:31,210
+واحدة من حيث الإعراب تختلف هنا لو وقفنا على الرايب
+
+487
+00:40:31,210 --> 00:40:36,470
+ذلك الكتاب ولا ريب إلا إنه نافع للجنس والرايب
+
+488
+00:40:36,470 --> 00:40:43,150
+اسمها وخبرها محذوف تقديره فيه بتكون الخبر خبر لا
+
+489
+00:40:43,150 --> 00:40:49,950
+نافي للجنس محذوف تقديره فيه وفيه هدى للمتقين بتكون 
+
+490
+00:40:49,950 --> 00:40:56,830
+فيه خبر مقدم وهدى مبتدأ مؤخر للمتقين متعلقة بهدى
+
+491
+00:40:56,830 --> 00:41:05,290
+يعني 
+
+492
+00:41:05,290 --> 00:41:10,810
+كل واحدة لها من حيث الإعراض وجه إعراض مثال آخر
+
+493
+00:41:10,810 --> 00:41:17,030
+مثلا في صوت المائدة قال فإنها محرمة عليهم أربعين
+
+494
+00:41:17,030 --> 00:41:22,310
+سنة يتيهون في الأرض فلا تأسى على القوم الفاسقين في 
+
+495
+00:41:22,310 --> 00:41:27,750
+عنا قال فإنها محرمة عليهم في فوق عليهم تلت نقات 
+
+496
+00:41:27,750 --> 00:41:32,770
+طبعا بتكون جنبها إنما بتكون فوقها وأربعين سنة 
+
+497
+00:41:32,770 --> 00:41:38,890
+بتكون فوق السنة تلت نقاتو يتيهون في الأرض معناته 
+
+498
+00:41:38,890 --> 00:41:43,570
+أنه يا إما تقف على الأولى ولها معنى يا إما تقف 
+
+499
+00:41:43,570 --> 00:41:49,350
+على الثانية ولها معنى هنا قال فإنها محرمة عليهم
+
+500
+00:41:49,350 --> 00:41:53,650
+وقفت على الأولى لا أقف على الثانية فأقول أربعين
+
+501
+00:41:53,650 --> 00:41:59,390
+سنة يتيهون في الأرض فلا تأس على القوم الفاسقين ما
+
+502
+00:41:59,390 --> 00:42:03,100
+معنى الآية؟ طبعا الآية تتكلم على مين؟ على بني
+
+503
+00:42:03,100 --> 00:42:05,560
+إسرائيل الذين كانوا مع سيدنا موسى عليه الصلاة
+
+504
+00:42:05,560 --> 00:42:09,160
+والسلام والذي أمرهم بأن يدخلوا الأرض المقدسة 
+
+505
+00:42:09,160 --> 00:42:13,760
+لكنهم قالوا اذهب أنت وربك فقاتلا إنها هنا قاعدون 
+
+506
+00:42:13,760 --> 00:42:17,880
+وقالوا إن فيها قوما جبارين وإن لم ندخلها أبدا ما 
+
+507
+00:42:17,880 --> 00:42:21,340
+داموا فيها فإي يخرجوا منها فإنا داخلون الجماعة
+
+508
+00:42:21,340 --> 00:42:24,720
+جماعة رب على العبودية كانوا عبيد عند الفراعنة
+
+509
+00:42:24,720 --> 00:42:28,780
+ظلهم أذلة فعايشين في حالة المثلنة لما قالهم بدنا 
+
+510
+00:42:28,780 --> 00:42:31,820
+نحارب خافوا مش لعون حرب فقال روح حارب أنت و
+
+511
+00:42:31,820 --> 00:42:35,300
+ربنا اذهب أنت و ربك فقاتلها إنها هنا قاعدون
+
+512
+00:42:35,300 --> 00:42:38,840
+ورفضوا أن يدخلوا الأرض المقدسة إلى ربنا عز وجل قال 
+
+513
+00:42:38,840 --> 00:42:44,480
+لهم ادخلوها فهنا ربنا أراد أن يعاقبهم فقال فإنها
+
+514
+00:42:44,480 --> 00:42:51,000
+محرمة عليهم بعدين أربعين سنتين يتيهون في الأرض ما
+
+515
+00:42:51,000 --> 00:42:56,010
+معنى الآية هذه؟ فقال فإنها محرمة عليهم تحريما أبديا
+
+516
+00:42:56,010 --> 00:43:01,130
+وعقوبة على قولكم أربعين سنة هتظلكم تايهين التحريم
+
+517
+00:43:01,130 --> 00:43:05,530
+أبدي وأربعين سنة هتظلكم تايهين في الأرض هذا معنى 
+
+518
+00:43:05,530 --> 00:43:11,030
+المعنى الثاني قال فإنها محرمة عليهم أربعين سنة 
+
+519
+00:43:12,220 --> 00:43:16,820
+بعدين يتيهون في الأرض فلا تأسى على القوم الفاسقين 
+
+520
+00:43:16,820 --> 00:43:21,840
+لها معنى آخر أن مدة التحريم عليهم أربعين سنة 
+
+521
+00:43:21,840 --> 00:43:26,240
+وبعدين حطوه في الأرض فترة يعني سنة شهر شهرين سنتين
+
+522
+00:43:26,240 --> 00:43:31,980
+تلاتة لو قلنا من حيث التاريخ والواقع ما هي المعنى
+
+523
+00:43:31,980 --> 00:43:37,830
+على أي معنى كان هو الواقع الأول ولا الثاني؟ التحقيق
+
+524
+00:43:37,830 --> 00:43:41,710
+الأول بيقولهم محرمة عليهم أبدا ممنوع تخشوها أرض 
+
+525
+00:43:41,710 --> 00:43:45,850
+اللي هي أرض فلسطين وبعدين فترة العقوبة أربعين
+
+526
+00:43:45,850 --> 00:43:51,850
+سنة المعنى الثاني أنه ممنوع تدخلوها محرم عليهم بس 
+
+527
+00:43:51,850 --> 00:43:56,110
+أربعين سنة وبعد أربعين سنة يجوز لكم أن تدخلوها و
+
+528
+00:43:56,110 --> 00:43:59,930
+عشان الكلمتين هدول اللي اتكلمتوها عقوبة لكم حطيها
+
+529
+00:43:59,930 --> 00:44:04,230
+في الأرض فترة أي معنى اللي طبق في التاريخ المعنى 
+
+530
+00:44:04,230 --> 00:44:10,840
+الثاني لأن اليهود طبعا حرمت عليهم أربعين سنة وفي 
+
+531
+00:44:10,840 --> 00:44:14,300
+فترة الأربعين سنة توفي موسى عليه الصلاة والسلام
+
+532
+00:44:14,300 --> 00:44:19,960
+وتوفي هارون واليهود طبعا بقوا معاهم وأرسل الله
+
+533
+00:44:19,960 --> 00:44:24,340
+عز وجل لهم طالوت ملكة وقاد الجماعة .. قادة بني
+
+534
+00:44:24,340 --> 00:44:28,040
+إسرائيل وكان عددهم سبعين ألفا وأراد أن يدخل 
+
+535
+00:44:28,040 --> 00:44:31,780
+الأرض المقدسة طبعا ليش أربعين سنة يا أخوات؟ لأنه 
+
+536
+00:44:31,780 --> 00:44:36,050
+اتغير الجيل .. جيل تلبى الأول على العبودية كل الجيل
+
+537
+00:44:36,050 --> 00:44:39,350
+كان فاسد نريد أن ينشأ جيل جديد خلال أربعين سنة
+
+538
+00:44:39,350 --> 00:44:43,170
+فنشأ الجيل الجديد وجاء بالسبعين ألف أرادوا أن
+
+539
+00:44:43,170 --> 00:44:46,270
+يدخلوا الأرض المقدسة فابتلاهم الله سبحانه وتعالى
+
+540
+00:44:46,270 --> 00:44:50,210
+فقال إن أمامكم نهر لا تشربوا منه وإلا من اغترف
+
+541
+00:44:50,210 --> 00:44:54,170
+غرفة بيده فالسبعين ألف لحد ما شافوا النهر كانوا 
+
+542
+00:44:54,170 --> 00:44:58,210
+عطشانين شربوا منه إلا قليل منهم كم هو هذا القليل
+
+543
+00:44:58,210 --> 00:45:03,550
+الذي لم يشرب من الماء؟ بس 314 رجل الرسول عليه 
+
+544
+00:45:03,550 --> 00:45:06,630
+الصلاة والسلام يقول إن عيدة بني إسرائيل الذين
+
+545
+00:45:06,630 --> 00:45:11,050
+صبروا مع داود أو مع طلوت كعيدة أهل بدر عددهم زي 
+
+546
+00:45:11,050 --> 00:45:16,170
+عدد أهل بدر ال 314 رجلا دخلوا الأرض المقدسة 
+
+547
+00:45:16,170 --> 00:45:21,810
+وانتصروا على جالوت اللي هو ملك العمالقة وكان معهم
+
+548
+00:45:21,810 --> 00:45:25,430
+من طلوت ملكة ومعهم سيدنا داود وكان غلاما صغيرا
+
+549
+00:45:25,930 --> 00:45:30,990
+السيدة قال للملك طلوت من قتل فيكم جالوت له نصف
+
+550
+00:45:30,990 --> 00:45:37,690
+ملكي وأزوجه ابنتي فمن عنكم يقتل جالوت الكل خاف إلا
+
+551
+00:45:37,690 --> 00:45:41,010
+الغلام اللي هو سيدنا داود عليه الصلاة والسلام فقال
+
+552
+00:45:41,010 --> 00:45:44,390
+أنا أقتله طيب ما هي امتيازاتك؟ أيش الفطورات التي 
+
+553
+00:45:44,390 --> 00:45:48,330
+تجعلك تقتل هذا العملاق الضخم؟ الواحد طوله طول نخلة 
+
+554
+00:45:48,330 --> 00:45:53,060
+وضخم وعملاق وجوي وملك وكل بسمعله؟ فقال أنا كنت راعي
+
+555
+00:45:53,060 --> 00:45:58,620
+ومعي المقلاع وإذا جاء الذئب لي ضربته بالمقلاع
+
+556
+00:45:58,620 --> 00:46:03,940
+فأقتله مباشرة أنا بقصيه فقال اتوكى الله بدت الحرب 
+
+557
+00:46:03,940 --> 00:46:07,160
+من حد ما بدت الحرب سيدنا داود حط الحجر في المقلاع
+
+558
+00:46:07,160 --> 00:46:12,300
+وقال بسم الله وأطلق الحجر فإذا بيه برأس من؟ برأس
+
+559
+00:46:12,300 --> 00:46:17,820
+جالوت فقتل جالوت العمالقة رأوا أن أميرهم وملكهم مات 
+
+560
+00:46:17,820 --> 00:46:22,900
+ففروا هربين فانتصر الفئة القليلة عن الفئة الكثيرة
+
+561
+00:46:22,900 --> 00:46:27,330
+بإذن الله عز وجل، وربنا سبحانه وتعالى يقول لنا كان
+
+562
+00:46:27,330 --> 00:46:32,090
+من فئة قليلة غلبت فئة كثيرة بإذن الله فصار داود 
+
+563
+00:46:32,090 --> 00:46:37,630
+اللي هو غلام هو صار بعد طلوت هو الملك ومتزوج بنت 
+
+564
+00:46:37,630 --> 00:46:41,950
+الملك وصار هو الملك وخلف سيدنا سليمان هنا طبعا
+
+565
+00:46:41,950 --> 00:46:45,510
+فترة التحريم كام سنة؟ أربعين سنة لكن فترة اللي
+
+566
+00:46:45,510 --> 00:46:49,210
+يتيهون في الأرض فترة قليلة اتقهوا في الأرض وبعدين
+
+567
+00:46:49,210 --> 00:46:51,790
+قالوا يا موسى احنا لن ناصف على طعام الواحد بدنا 
+
+568
+00:46:51,790 --> 00:46:55,110
+ناكل من الفول والعدس والحمص وكده فقال الله
+
+569
+00:46:55,110 --> 00:46:59,080
+ادخلوا مصر دخلوا إلى مصر وانتهت فترة التيه في سنة
+
+570
+00:46:59,080 --> 00:47:02,780
+أو سنتين لم يسفروا مع أن الله سبحانه وتعالى رزقهم 
+
+571
+00:47:02,780 --> 00:47:06,040
+بالمن والسلوك ولكنهم لا يريدوا الطيبات وأرادوا 
+
+572
+00:47:06,040 --> 00:47:10,620
+الطعام الذي هو دنيء مما يريدونه اكتفيني يا 
+
+573
+00:47:10,620 --> 00:47:13,800
+أخوات بالوقف القبيح وإن شاء الله في اللقاء القادم 
+
+574
+00:47:13,800 --> 00:47:18,260
+هنأخذ القطع وكذلك الابتداء نكتفي بهذا القدر
+
+575
+00:47:18,260 --> 00:47:20,040
+والسلام عليكم ورحمة الله وبركاته 
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY.srt
new file mode 100644
index 0000000000000000000000000000000000000000..8661f4705d9ae184b57cd9fc901f390db3874d8c
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY.srt
@@ -0,0 +1,2175 @@
+1
+00:00:11,620 --> 00:00:14,480
+أعوذ بالله من الشيطان الرجيم بسم 
+
+2
+00:00:14,480 --> 00:00:18,160
+الله الرحمن الرحيم الصلاة والسلام على سيد المرسلين
+
+3
+00:00:18,160 --> 00:00:26,560
+وعلى آله وصحبه أجمعين، أما بعد، مجهزين يا إخوان؟
+
+4
+00:00:26,560 --> 00:00:31,000
+يالله يا بسمة، طلعي يا الله صورة الشورى، الآية 32
+
+5
+00:00:31,000 --> 00:00:37,420
+ومن آياته الجوارف البحر كالأعلام أعوذ بالله السميع 
+
+6
+00:00:37,420 --> 00:00:45,920
+العليم من الشيطان الرجيم بسم الله الرحمن الرحيم
+
+7
+00:00:45,920 --> 00:00:55,870
+ومن آياته الجوارف البحر كالأعلام إن يشأ يسكن الريح
+
+8
+00:00:55,870 --> 00:01:05,010
+فيظللنا رواكد فيظللنا رواكد على ظهره إن في ذلك
+
+9
+00:01:05,010 --> 00:01:09,950
+لآيات لكل صبار شكوى
+
+10
+00:01:12,270 --> 00:01:16,370
+أو يبقهن بما كسبوا .. قفي ساكنة .. قفي ساكنة يعني،
+
+11
+00:01:16,370 --> 00:01:21,910
+بس ما .. خليها ساكنة أو يبقهن .. أو يبقهن بما
+
+12
+00:01:21,910 --> 00:01:29,090
+كسبوا ويعفوا عن كثير كثير، إيش حكم الرأهان؟ مرقق،
+
+13
+00:01:29,090 --> 00:01:30,970
+مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق،
+
+14
+00:01:30,970 --> 00:01:32,470
+مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق،
+
+15
+00:01:32,470 --> 00:01:40,190
+مرقق، مرقق، مرقق، مرقق
+
+16
+00:01:41,420 --> 00:01:53,480
+ويعلم الذين يجادلون في آياتنا ما لهم من محيص فما 
+
+17
+00:01:53,480 --> 00:02:05,690
+أوتيتهم من شيء فمتاع الحياة الدنيا وما عند الله خير
+
+18
+00:02:05,690 --> 00:02:16,770
+وأبقى للذين آمنوا وعلى ربهم يتوكلون والذين يجتنبون
+
+19
+00:02:16,770 --> 00:02:24,890
+كبائر الإثم والفواحش وإذا ما غضبوا .. وإذا ما 
+
+20
+00:02:24,890 --> 00:02:30,190
+غضبوا هم يغفرون الله يفتح عليك، اقرئي يا سوزان
+
+21
+00:02:40,050 --> 00:02:48,810
+والذين استجابوا لربهم وأقاموا الصلاة وأمروا
+
+22
+00:02:48,810 --> 00:02:57,010
+مشورة بينهم ومما رزقناهم ينفقون
+
+23
+00:02:57,010 --> 00:03:01,090
+والذين
+
+24
+00:03:01,090 --> 00:03:01,730
+إذا 
+
+25
+00:03:06,870 --> 00:03:18,530
+والليل إذا أصابهم البغيهم 
+
+26
+00:03:18,530 --> 00:03:25,850
+ينتصرون هم ينتصرون عيبا، إيش الحكم هان؟ تبع تبع
+
+27
+00:03:29,940 --> 00:03:43,080
+وجزاء سيئة سيئة مثلها لمن عفا
+
+28
+00:03:43,080 --> 00:03:50,160
+وأصلح فأجره على الله أجره،  رأم ضمون فأجره على
+
+29
+00:03:50,160 --> 00:03:59,040
+الله إنه لا يحب الظالمين ولا .. ولا من انتصر بعد ..
+
+30
+00:03:59,040 --> 00:04:01,540
+ولا من .. برضه الإخساط، ليش ده ما اللي بتنسوا
+
+31
+00:04:01,540 --> 00:04:10,280
+الإخساط إنتوا؟ إيش حروف الإخساط عندنا؟ هايك 
+
+32
+00:04:10,280 --> 00:04:12,800
+وشاطريه، نطبق النظر اللي أخدنا على العمل اللي
+
+33
+00:04:12,800 --> 00:04:19,640
+معانا، يلا و لا .. ولا من انتصر بعد غلمه فأولئك ..
+
+34
+00:04:19,640 --> 00:04:23,580
+بعد غلمه فأولئك 
+
+35
+00:04:30,060 --> 00:04:35,640
+برضه الإخفاء يا سوزان من سبيل .. إخفاء لكن أجرح
+
+36
+00:04:35,640 --> 00:04:42,890
+إيه؟ في كلمتين يلا إنما .. إنما السبيل على الذين 
+
+37
+00:04:42,890 --> 00:04:48,090
+يظلمون الناس ويبغون في ال .. ويبغون في ال .. دائما
+
+38
+00:04:48,090 --> 00:04:53,710
+أصل يا أخوات، يظلمون الناس ويبغون في الأرض، أصل
+
+39
+00:04:53,710 --> 00:05:00,220
+لأن المعنى مترابط إنما السبيل على الذين يظلمون
+
+40
+00:05:00,220 --> 00:05:07,680
+الناس ويبغون في الأرض بغير الحق أولئك لهم عذاب
+
+41
+00:05:07,680 --> 00:05:12,220
+أليم ولمن
+
+42
+00:05:12,220 --> 00:05:25,520
+صبر وغفر إن ذلك لمن عزم الأمور ومن يظلم 
+
+43
+00:05:26,020 --> 00:05:35,940
+ومن يضل الله فما له من ولي من .. من ولي
+
+44
+00:05:35,940 --> 00:05:44,600
+من بعده وترى الظالمين لما رأوا العذاب يقولون هل
+
+45
+00:05:44,600 --> 00:05:49,860
+.. يقولون هل إلى .. هل إليه مرد من سبيل .. يقولون
+
+46
+00:05:49,860 --> 00:05:55,020
+هل إلى مرد من سبيل 
+
+47
+00:05:59,040 --> 00:06:15,260
+الله يفتح عليك قرأت آية دين؟ نعم يلا 
+
+48
+00:06:15,260 --> 00:06:18,880
+و
+
+49
+00:06:18,880 --> 00:06:19,460
+تراهم
+
+50
+00:06:24,670 --> 00:06:31,190
+يعرضون عليها خاشعين من الذل .. خاشعين من الذل
+
+51
+00:06:31,190 --> 00:06:39,470
+ينظرون من طرف .. من طرفهم طرف خفي من طرف خفي .. من 
+
+52
+00:06:39,470 --> 00:06:47,750
+طرف خفي .. خ .. خفي وقال الذين آمنوا إن الخاسرين ..
+
+53
+00:06:47,750 --> 00:06:51,550
+وين المد؟ إن الخاسرين .. إيش نوع المد ده يا دينا؟
+
+54
+00:06:51,550 --> 00:06:55,750
+حكم المد .. أمن ومع إن .. أمن ومع إن .. إيش نوع
+
+55
+00:06:55,750 --> 00:06:59,130
+المد؟ حكم المد المفصل .. حكم المد المفصل .. حكم
+
+56
+00:06:59,130 --> 00:06:59,990
+المد المفصل .. حكم المد المفصل .. حكم المد المفصل
+
+57
+00:06:59,990 --> 00:07:01,170
+.. حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+58
+00:07:01,170 --> 00:07:03,290
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+59
+00:07:03,290 --> 00:07:06,610
+حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+60
+00:07:06,610 --> 00:07:10,270
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+61
+00:07:10,270 --> 00:07:10,650
+حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+62
+00:07:10,650 --> 00:07:11,110
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+63
+00:07:11,110 --> 00:07:22,080
+حكم المد المفصل ارجعي وقال الذين .. أيوة الذين
+
+64
+00:07:22,080 --> 00:07:32,180
+خسروا أنفسهم أنفسهم
+
+65
+00:07:32,180 --> 00:07:41,260
+وأهليهم وأهليهم يوم القيامة ألا إن الظالمين في عذاب 
+
+66
+00:07:41,260 --> 00:07:49,460
+مقيم وما
+
+67
+00:07:49,460 --> 00:07:55,820
+كان لهم من أولياء 
+
+68
+00:07:55,820 --> 00:08:04,740
+ينصرونهم من أولياء ينصرونهم من دون الله ومي يضب
+
+69
+00:08:04,740 --> 00:08:11,920
+الله فالله فما له من سبيل فما له .. فما له من سبيل
+
+70
+00:08:11,920 --> 00:08:19,520
+من سبيل استجيبوا .. استجيبوا .. استجيبوا لربكم
+
+71
+00:08:19,520 --> 00:08:26,580
+استجيبوا لربكم من قبل أن يأتي يوم لهم أن يأتي يه
+
+72
+00:08:26,580 --> 00:08:27,900
+اليه مفتوحة 
+
+73
+00:08:32,650 --> 00:08:40,030
+لا مارد له .. مارد له من الله ما لكم من .. من ملجأ
+
+74
+00:08:40,030 --> 00:08:44,770
+يومئذ .. جيب الإضغام حركتين يا دينا من ملجأ .. من 
+
+75
+00:08:44,770 --> 00:08:55,110
+ملجأ يومئذ .. يومئذ وما لكم من .. من كيل .. يلا 
+
+76
+00:08:55,110 --> 00:09:06,690
+يا رنا الله يفتح عليك إن 
+
+77
+00:09:06,690 --> 00:09:16,050
+.. النون مخففة أدقنا
+
+78
+00:09:16,050 --> 00:09:17,410
+لإنسان 
+
+79
+00:09:19,560 --> 00:09:28,600
+إن رحمة فارح بها وإن تصدهم سيئة بما قدمت أيديهم
+
+80
+00:09:28,600 --> 00:09:34,940
+فإن الإنسان كفور لله جمهور السماوات والأرض
+
+81
+00:09:52,570 --> 00:09:55,350
+مي شاء
+
+82
+00:10:02,430 --> 00:10:09,650
+رقق الرأي يا راني قدير .. قدر
+
+83
+00:10:09,650 --> 00:10:13,690
+هي
+
+84
+00:10:13,690 --> 00:10:17,190
+يكلمه أو
+
+85
+00:10:21,520 --> 00:10:27,260
+أو بوراء حجاب .. حجاب أو يرسل .. أو يرسل رسولة أو
+
+86
+00:10:27,260 --> 00:10:32,840
+يرسل رسولة أو يرسل رسولة فيوحي .. فيوحي بإذنه ما
+
+87
+00:10:32,840 --> 00:10:42,420
+يشاء إنه علي حكيم الله يفتح عليه طريقة حلوة أعوذ
+
+88
+00:10:42,420 --> 00:10:49,280
+بالله من الشيطان الرجيم وكذلك أوحينا وكذلك أوحينا 
+
+89
+00:10:49,280 --> 00:10:55,620
+إليك روحا من أمرنا ما كنت تدري ما الكتاب ولا
+
+90
+00:10:55,620 --> 00:11:06,160
+الإيمان ولكن
+
+91
+00:11:06,160 --> 00:11:07,120
+رجعنا
+
+92
+00:11:12,030 --> 00:11:15,810
+وأنا المادة، المادة المقتصرة
+
+93
+00:11:39,160 --> 00:11:40,720
+الله يفتح عليك 
+
+94
+00:11:49,880 --> 00:12:01,500
+عزيزي من الرحمن الغربي إذا قصصت آياته قصصنا عربيا
+
+95
+00:12:01,500 --> 00:12:05,640
+عربيا لقوم يعلمها 
+
+96
+00:12:17,200 --> 00:12:27,720
+والخلوقنا في أكنة
+
+97
+00:12:27,720 --> 00:12:38,800
+والخلوقنا في أكنة مما تدعونا مما تدعونا
+
+98
+00:12:43,120 --> 00:12:54,740
+وادعونا إليه ودي أفاننا ودي أفاننا وقروه من بيننا
+
+99
+00:12:54,740 --> 00:13:06,660
+وقروه من .. وقروه من بيننا وبينك حجاب فاعمل إننا
+
+100
+00:13:06,660 --> 00:13:08,340
+عاملون
+
+101
+00:13:11,330 --> 00:13:15,510
+برضه غني حركتين عنهم يا إمام؟
+
+102
+00:13:44,750 --> 00:13:55,280
+لا يقتون الذين لا يؤتون الزكاة وهم بالآخرة .. وهم
+
+103
+00:13:55,280 --> 00:13:59,820
+بالآخرة .. إيش الحكم ها؟ أقلام .. لا مش أقلام 
+
+104
+00:13:59,820 --> 00:14:02,400
+فأشى فوي .. فأشى فوي .. فأشى فوي .. فأشى فوي ..
+
+105
+00:14:02,400 --> 00:14:03,660
+فأشى فوي .. فأشى فوي .. فأشى فوي .. فأشى فوي ..
+
+106
+00:14:03,660 --> 00:14:08,860
+فأشى فوي .. فأشى فوي .. فأشى فوي .. فأشى فوي ..
+
+107
+00:14:08,860 --> 00:14:13,080
+فأشى فوي .. فأشى فوي .. فأشى فوي .. فأشى فوي ..
+
+108
+00:14:13,080 --> 00:14:14,120
+فأشى فوي .. فأشى فوي .. فأشى فوي .. فأشى فوي ..
+
+109
+00:14:14,120 --> 00:14:15,900
+فأشى فوي .. فأشى فوي .. فأ
+
+110
+00:14:26,640 --> 00:14:33,660
+قُلّي أكسري الهمزة التانية كويس، قُلّي أإنكم 
+
+111
+00:14:33,660 --> 00:14:39,140
+مد
+
+112
+00:14:39,140 --> 00:14:43,410
+الصلاة، جدش من مد الصلاة الكبرى يا صابرين؟ وتجعلون
+
+113
+00:14:43,410 --> 00:14:51,590
+له أندادا .. twice .. وتجعلون له أندادا .. تلالي 
+
+114
+00:14:51,590 --> 00:14:57,710
+كرب العالمين وجعل فيها رواسيا من فوقها وبرك فيها 
+
+115
+00:14:57,710 --> 00:15:04,630
+وقدر فيها أقوتها في أربعة أيام سواء
+
+116
+00:15:06,680 --> 00:15:11,920
+بس ما تجافيش شوية علامة زي الغناء لأ في أربعة أيام
+
+117
+00:15:11,920 --> 00:15:21,920
+سواء للسائلين في أربعة أيام سواء للسائلين لأ سواء 
+
+118
+00:15:21,920 --> 00:15:29,100
+الـ .. ده غلط، ناشن الجافة عليها سواء للسائلين سواء
+
+119
+00:15:29,100 --> 00:15:33,920
+للسائلين طب ليش بتلمد؟ سواء .. إيه؟
+
+120
+00:15:46,940 --> 00:15:54,220
+سواء السائلين .. سواء السائلين .. ثم سواء السائلين
+
+121
+00:15:54,220 --> 00:15:55,700
+.. دي بالغناء علمين حركتين
+
+122
+00:16:00,510 --> 00:16:05,610
+وهي ده ما قلنا لها فهو وهي تكسر وليست ساكنة وأن 
+
+123
+00:16:05,610 --> 00:16:11,770
+ده الإمام حفظ وهي دخان وهي دخان فقال لها وللأرض
+
+124
+00:16:11,770 --> 00:16:19,610
+أتيا طوعا طوعا أو كرها قالت أتينا طائعين الله يفتح
+
+125
+00:16:19,610 --> 00:16:23,890
+عليه يلا
+
+126
+00:16:23,890 --> 00:16:30,780
+يا إيمان اقرئي أعوذ بالله من الشيطان الرجيم بسم الله
+
+127
+00:16:30,780 --> 00:16:37,180
+الرحمن الرحيم قفضه من سبع .. قفضه من سبع سموات ..
+
+128
+00:16:37,180 --> 00:16:42,740
+قفضه من سبع سموات في يومين وروحا في كل سماء أمرها
+
+129
+00:16:42,740 --> 00:16:50,260
+.. في كل سماء أمرها وأوحى في كل سماء أمرها وزين 
+
+130
+00:16:50,260 --> 00:16:54,180
+السماء .. قفضه من سماء .. قفضه من سماء .. قفضه من 
+
+131
+00:17:03,450 --> 00:17:11,430
+فقول في أنها حكم، أيوة، إيش الـ .. إيش الحكم؟ أيوة،
+
+132
+00:17:11,430 --> 00:17:17,970
+فمقدرة حركته، سائقة كان مثل
+
+133
+00:17:43,060 --> 00:17:50,340
+بما أرسلتم به فإن
+
+134
+00:17:50,340 --> 00:17:52,000
+بما أرسلتم به 
+
+135
+00:17:59,830 --> 00:18:04,870
+فأنا عادوا فاستكبروا في الأرض جبال الحق وقالوا من 
+
+136
+00:18:04,870 --> 00:18:11,910
+أشد منا قوة .. لأ عندي الوقف، قوة، بصير أنا همس
+
+137
+00:18:11,910 --> 00:18:17,250
+في الهاق، مش قوة، قوة، نسكن الحرف، اه
+
+138
+00:18:24,800 --> 00:18:31,640
+وأشدّ منهم قوة الله 
+
+139
+00:18:31,640 --> 00:18:39,670
+يفتح عليك قرأت سريع بسم الله الرحمن الرحيم فأرسلنا 
+
+140
+00:18:39,670 --> 00:18:46,530
+عليهم ريحا سرسرا في 
+
+141
+00:18:46,530 --> 00:18:57,190
+أيام نحسات لينذيقهم عذاب القذي في حياة الدنيا ولا
+
+142
+00:18:57,190 --> 00:19:07,020
+عذاب الآخرة أخذاوهم لا ينصرون وأما ثمود فهديناهم
+
+143
+00:19:07,020 --> 00:19:11,580
+فاستحبوا العَمّ .. فاستحبوا .. فاستحبوا العَمّ على ..
+
+144
+00:19:11,580 --> 00:19:18,580
+فاستحبوا العَمّ على الهدى .. على الهدى فأخذتهم صارقة
+
+145
+00:19:18,580 --> 00:19:25,730
+العذاب الهون .. الهون بمادة العذاب الهون العذاب
+
+146
+00:19:25,730 --> 00:19:32,970
+الهون بما كانوا يكسبون ونجينا الذين آمنوا وكانوا
+
+147
+00:19:32,970 --> 00:19:37,510
+يتقون آمنوا .. يعني حرف المد .. جيبي حركتين ..
+
+148
+00:19:37,510 --> 00:19:42,090
+يا ديشر بندن مد حروف المد يا إسراء؟ حروف المد .. كام
+
+149
+00:19:42,090 --> 00:19:45,350
+بندن؟ مد حركتين .. أه حركتين .. مد أصلي أو طبيعي
+
+150
+00:19:45,350 --> 00:19:48,990
+يمد مقدار حركتين .. يلا عيد الآية .. ونجينا الذين
+
+151
+00:19:48,990 --> 00:19:57,570
+.. لأ أكثر أكتر من حرفتين أحسنت
+
+152
+00:20:23,410 --> 00:20:33,590
+وجلودهم بما كانوا يعملون وقالوا
+
+153
+00:20:33,590 --> 00:20:36,270
+لجلودهم 
+
+154
+00:20:37,240 --> 00:20:45,460
+وقالوا لجلودهم لم .. لم شهدتم علينا قالوا أنطقنا
+
+155
+00:20:45,460 --> 00:20:54,300
+الذي .. أنطقنا الله الذي أنطق كل شيء .. كل .. كل
+
+156
+00:20:54,300 --> 00:21:01,340
+شيء وهو خلقكم .. و هو .. و هو خلقكم أول مرة و
+
+157
+00:21:01,340 --> 00:21:04,280
+إليه ترجعون بيفتحوا
+
+158
+00:21:15,160 --> 00:21:26,620
+بدي أرد على
+
+159
+00:21:26,620 --> 00:21:31,740
+الجوال يا أستاذ، أه؟ الدكتور، رئيس القسم السلام
+
+160
+00:21:31,740 --> 00:21:40,790
+عليكم السلام عليكم .. عليكم السلام .. بسم الله ..
+
+161
+00:21:40,790 --> 00:21:42,050
+أيوة معك يا وستاني
+
+162
+00:21:51,910 --> 00:21:55,450
+عارفين يقولوا أنك عارفينها؟ لأ أخصوش عليهم أنا بس
+
+163
+00:21:55,450 --> 00:21:58,230
+بحذرهم ما يتأخروش أكتر من المعودة لحد اليومية يعني
+
+164
+00:21:58,230 --> 00:22:02,810
+و أنا في بعض اللي بيجي وزمانيها أدرس في أديانة؟ لأ 
+
+165
+00:22:02,810 --> 00:22:06,550
+أصلا والله كتير بيجي اليوم عشرين طالب أجلوا أجلتهم 
+
+166
+00:22:06,550 --> 00:22:10,190
+يومين تلاتة بس ما يزلوش أزيادة عن اللزوم عشان
+
+167
+00:22:10,190 --> 00:22:12,670
+ما يصيرش ضغط على باجي الطالبات يعني اللي في
+
+168
+00:22:12,670 --> 00:22:17,350
+مواعيدهم هدولة أول في ميسا قدرتوا مجرد قدر منهم؟
+
+169
+00:22:17,350 --> 00:22:22,190
+ما فيش حدر؟ ماشاء الله، بس أنت الله يبارك فيك، يعني نبّههم
+
+170
+00:22:22,190 --> 00:22:26,610
+اللي هم ييجوا في مواعيدهم ما شاء الله، يعطيكي
+
+171
+00:22:26,610 --> 00:22:31,310
+العافية، سلامة
+
+172
+00:22:31,310 --> 00:22:39,050
+ماللي
+
+173
+00:22:39,050 --> 00:22:43,610
+كنت تقرأ؟ يعني ما أعرفش اسمك، ذكريني يعني، يلا يا
+
+174
+00:22:43,610 --> 00:22:43,930
+شيرين
+
+175
+00:22:51,310 --> 00:22:56,690
+أي يشهد .. يشهد
+
+176
+00:22:56,690 --> 00:23:07,090
+عليكم سماعكم ولا جلودكم
+
+177
+00:23:07,090 --> 00:23:12,190
+وعنانتم،
+
+178
+00:23:12,190 --> 00:23:13,550
+لا يخفى يا شيرين
+
+179
+00:23:21,350 --> 00:23:35,590
+أرجع وأصلي لآية ولكن ظننتم ميمة
+
+180
+00:23:35,590 --> 00:23:42,970
+جامعة مضمونة وذلكم غنكم الذي غنكم
+
+181
+00:23:59,130 --> 00:24:05,870
+وذلكم ضنكم الذي ظننتم بربكم
+
+182
+00:24:16,680 --> 00:24:20,560
+أرضاكم فأصبحتم من الخاسرين خزيب يتغامل مين مع
+
+183
+00:24:20,560 --> 00:24:29,960
+المين؟ أصبحتم من الخاسرين من الخ .. الخاسرين
+
+184
+00:24:29,960 --> 00:24:35,740
+فأصبحتم من الخاسرين .. من الخاسرين مش الخ .. الخ
+
+185
+00:24:35,740 --> 00:24:38,100
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+186
+00:24:38,100 --> 00:24:38,560
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+187
+00:24:38,560 --> 00:24:41,100
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+188
+00:24:41,100 --> 00:24:41,640
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+189
+00:24:41,640 --> 00:24:42,700
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+190
+00:24:42,700 --> 00:24:49,570
+.. خاسرين .. عشان إيش؟ قبلها، مش بعدها، قبلها حرف
+
+191
+00:24:49,570 --> 00:24:53,290
+من حروف الصداق تنقض، حروف التخيم والاستعلاء، بنقول
+
+192
+00:24:53,290 --> 00:24:59,990
+.. مش بقولش الخاسرين، الخ .. غلط، الخاسرين، كامل
+
+193
+00:24:59,990 --> 00:25:02,930
+وإيه يستعتبوا
+
+194
+00:25:13,940 --> 00:25:17,440
+من المعتبين بس ارجع واسيبي برضه اتغمل من معلمين
+
+195
+00:25:17,440 --> 00:25:24,840
+حركتين فما هم من المعتبين فما هم من المعتبين و
+
+196
+00:25:24,840 --> 00:25:31,420
+قضينا لهم قرناء وقيدنا لهم قرناء لأ فخمة ضاب و
+
+197
+00:25:31,420 --> 00:25:40,120
+قيدنا لهم قرناء وقيدنا ضاب وقيدنا لهم قرناء و
+
+198
+00:25:40,120 --> 00:25:41,820
+فزينا لهم قرناء
+
+199
+00:25:44,850 --> 00:25:51,970
+الهمز مفتوحة يعني قرنا أفزينوا وقيدنا لهم قرنا
+
+200
+00:25:51,970 --> 00:25:58,930
+أفزينوا لهم ما بين .. لهم .. لهم ما .. لهم ما بين
+
+201
+00:25:58,930 --> 00:26:04,390
+أيديهم وما خلف .. وما خلفهم وحق عليهم .. وحق عليهم
+
+202
+00:26:04,390 --> 00:26:08,070
+عليهم القور من .. القور من .. اكسر الحق كويس قبل
+
+203
+00:26:08,070 --> 00:26:14,350
+الميم عليهموا عليهم القور في أمهم جيبي الماد
+
+204
+00:26:14,350 --> 00:26:22,170
+يا شيرين، إيش هالنوع الماد؟ ماد جائز وانفصل، جداش
+
+205
+00:26:22,170 --> 00:26:27,610
+مقدار يا شيرين الماد جايز وانفصل؟ أربع أو خمس
+
+206
+00:26:27,610 --> 00:26:31,510
+حركات، طب يالا جيبي، يا أربع يا خمس حركات وحفظ
+
+207
+00:26:31,510 --> 00:26:37,690
+عليهم القول في .. عليهم .. عليهم القول .. عليهم
+
+208
+00:26:37,690 --> 00:26:44,590
+القول في أمم .. في أمم قد خلت من قبلهم .. من قبلهم
+
+209
+00:26:44,590 --> 00:26:55,510
+.. من الجن والإنس
+
+210
+00:26:55,510 --> 00:27:02,030
+وقيدنا
+
+211
+00:27:02,030 --> 00:27:08,430
+لهم قرن أفذين لهم ما بين أيديهم .. ما بين أيديهم
+
+212
+00:27:08,430 --> 00:27:14,420
+وما خلفهم .. وما خلفهم وحق عليهم القول .. وحق عليهم
+
+213
+00:27:14,420 --> 00:27:18,140
+القول في .. برضه ضمن مين؟ عليهم القول .. عليهم
+
+214
+00:27:18,140 --> 00:27:27,360
+القول في أمم قد خلت من قرضهم، قد خلت من قبلهم من
+
+215
+00:27:27,360 --> 00:27:34,930
+الجن والإنس إنهم كانوا خاسرين، خاسرين،
+
+216
+00:27:34,930 --> 00:27:40,430
+خاسرين،
+
+217
+00:27:40,430 --> 00:27:45,650
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+218
+00:27:45,650 --> 00:27:45,690
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+219
+00:27:45,690 --> 00:27:45,990
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+220
+00:27:45,990 --> 00:27:46,750
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+221
+00:27:46,750 --> 00:27:52,250
+خاسرين، خاسرين، خاسرين،
+
+222
+00:27:52,250 --> 00:27:53,650
+خاسرين، خاسرين
+
+223
+00:27:59,550 --> 00:28:15,450
+ولا .. ولا نجذيانهم أديها يا نهار قلني
+
+224
+00:28:15,450 --> 00:28:19,470
+عنهم يا نهار أعداء الله النار
+
+225
+00:28:22,400 --> 00:28:29,380
+مد .. مد المد المتصل جزاء .. جزاء .. جزاء أعداء
+
+226
+00:28:29,380 --> 00:28:36,520
+الله ناولهم فيها دارهم .. دارهم خد جزاء بما كان ..
+
+227
+00:28:36,520 --> 00:28:44,260
+جزاء بما كانوا بأياتنا يشهدوا وقال الذين كفروا
+
+228
+00:28:44,260 --> 00:28:50,480
+ربنا أرينا الذين .. الذين .. أرينا الذين .. الذين
+
+229
+00:28:50,480 --> 00:28:50,900
+.. الذين .. الذين .. الذين .. الذين .. الذين ..
+
+230
+00:28:53,440 --> 00:28:59,240
+الذين أضلنا من
+
+231
+00:28:59,240 --> 00:29:11,340
+الجن والإنس والإنسي والإنسي
+
+232
+00:29:11,340 --> 00:29:17,360
+والإنسي
+
+233
+00:29:17,360 --> 00:29:17,380
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+234
+00:29:17,380 --> 00:29:17,480
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+235
+00:29:17,480 --> 00:29:19,620
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+236
+00:29:19,620 --> 00:29:20,500
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+237
+00:29:20,500 --> 00:29:25,460
+والإنسي والإنسي والإنس نجعلهم تحت أقدامنا ليكونوا من
+
+238
+00:29:25,460 --> 00:29:32,600
+الأسفلين إن الذين قالوا ربنا الله ثم استقاموا ثم
+
+239
+00:29:32,600 --> 00:29:38,860
+استقاموا ثم استقاموا وتتنثروا عليهم ولا اجتوا ولا
+
+240
+00:29:38,860 --> 00:29:44,920
+تفافوا ألا تفافوا ولا تحزنوا وأبشروا بالجنة التي
+
+241
+00:29:44,920 --> 00:29:48,400
+كنتوا وابشروا بالجنة
+
+242
+00:29:52,680 --> 00:29:59,440
+التي .. التي كنتم .. كنتم توعدون .. الله يفتح
+
+243
+00:29:59,440 --> 00:30:06,200
+عليك .. الله يفتح عليك، تقرأي هنا أعوذ بالله من
+
+244
+00:30:06,200 --> 00:30:15,100
+الشيطان الرجيم بسم الله الرحمن الرحيم نحن أولياءكم
+
+245
+00:30:15,100 --> 00:30:21,860
+في الحياة الدنيا وفي الآخرة ولكم فيها ما تشتهي
+
+246
+00:30:21,860 --> 00:30:33,000
+أنفسكم ولكم فيها ما تدعون نزلا من غفور .. من غفور
+
+247
+00:30:33,000 --> 00:30:39,060
+الرحيم أيوه؟ إيش الحكم أنه غفور الرحيم؟ اتغام بدون
+
+248
+00:30:39,060 --> 00:30:43,990
+غنة أيوه اتغام بدون غنة، ليه؟ حرف .. نون مع الرأس
+
+249
+00:30:43,990 --> 00:30:47,730
+.. أيوة ده ما في أنا حرف الرأس .. يلا يلا ومن أحسن
+
+250
+00:30:47,730 --> 00:30:58,170
+قولًا ممن دعا إلى الله وعمل صالحًا وعمل صالحًا وقال
+
+251
+00:30:58,170 --> 00:31:06,930
+إنني من المسلمين ولا تستوي الحسنة ولا السيئة ادفع
+
+252
+00:31:06,930 --> 00:31:14,030
+بالتي هي أحسن فإذا الذي بينك وبينه عداوة فإذا الذي
+
+253
+00:31:14,030 --> 00:31:25,510
+بينك وبينه عداوة عداوة كأنه ولي حميم ما يلقها إلا
+
+254
+00:31:25,510 --> 00:31:33,310
+الذين صبروا وما
+
+255
+00:31:33,310 --> 00:31:44,830
+يلقها إلا ذو حظ عظيم وإما ينزغنك من الشيطان نزغ
+
+256
+00:31:44,830 --> 00:31:53,890
+فاستعذ بالله فاستعذ بالله إنه هو السميع العليم
+
+257
+00:31:53,890 --> 00:32:02,010
+الله يفتح عليك تكملّي يا حنان ومن
+
+258
+00:32:02,010 --> 00:32:07,630
+آياته الليلة الليل والنهار والشمس والقمر لا تسجدوا
+
+259
+00:32:07,630 --> 00:32:13,490
+للشمس ولا للقمر لا وابحثي اللي لا تسجدوا لا تسجدوا
+
+260
+00:32:13,490 --> 00:32:21,270
+للشمس ولا للقمر خلقهم إن كنتم تعملوا تفضلي
+
+261
+00:32:21,270 --> 00:32:26,410
+بالإخفاء الأول يا حنان إن كنتم تعملوا وإن
+
+262
+00:32:26,410 --> 00:32:31,790
+استثمروا فالذين عندهم عين لربك يسبحون له الليل
+
+263
+00:32:31,790 --> 00:32:41,650
+والنهار وهم لا يسألونه ومن آياته أنك
+
+264
+00:32:41,650 --> 00:32:42,890
+ترى الأرض قاحلة
+
+265
+00:32:45,880 --> 00:32:56,220
+قاحلة فإذا .. قاحلة فإذا أنزلنا عليها الماء تزدد
+
+266
+00:32:56,220 --> 00:33:05,560
+وربت إن الذي يحيي على محيي الموتى إنه على كل شيء ..
+
+267
+00:33:05,560 --> 00:33:12,040
+على كل شيء قدير إن الذين يحيون فيه
+
+268
+00:33:23,870 --> 00:33:29,550
+أما .. أما
+
+269
+00:33:29,550 --> 00:33:32,370
+يأتي أمنا
+
+270
+00:33:37,810 --> 00:33:50,890
+برضه عندنا الإضغام التاني أما يأتي أمنا
+
+271
+00:33:50,890 --> 00:33:57,870
+يوم القيامة اعملوا .. اعملوا ما شئتم إنه بما
+
+272
+00:33:57,870 --> 00:33:58,730
+تعملونه 
+
+273
+00:34:06,240 --> 00:34:12,400
+وإنه لكتاب عزيز لا يأتيه الباطل .. لا يأتيه
+
+274
+00:34:12,400 --> 00:34:22,080
+الباطل من بين يديه ولا من خلفه ولا من خلفه أظهر،
+
+275
+00:34:22,080 --> 00:34:27,560
+يعني النور مع الخأ من حروف الإظهار، صح؟ ولا من ..
+
+276
+00:34:27,560 --> 00:34:34,960
+ولا من خلفه لا زيل من حكيه برضه نفس الشيء يا حنان،
+
+277
+00:34:34,960 --> 00:34:43,400
+من حكي؟ من .. من حروف إيش؟ إيش حروف الإظهار؟ الله
+
+278
+00:34:43,400 --> 00:34:48,600
+يفتح عليك دي هي الآية، لا يأتيه الباطل لا يأتيه
+
+279
+00:34:48,600 --> 00:34:53,880
+الباطل .. لا يأتيه الباطل من بين يديه ولا من خلفه
+
+280
+00:34:53,880 --> 00:35:00,420
+تم .. ولا من خلفه تمثيل من حكيم حميد ما يقاربلك 
+
+281
+00:35:00,420 --> 00:35:06,360
+إلا .. ما يقارِبُك إلا ما قد قيل للرسول من قبلك إن
+
+282
+00:35:06,360 --> 00:35:12,920
+ربك لده مغفرتك وده عقاب أمين ما فتح عليه؟
+
+283
+00:35:20,220 --> 00:35:26,640
+و ده القلب و
+
+284
+00:35:26,640 --> 00:35:41,140
+هو
+
+285
+00:35:41,140 --> 00:35:47,160
+و
+
+286
+00:35:47,160 --> 00:35:56,240
+هو عليهم عناوالدنيا لا يوميون في أذانهم وخمومة
+
+287
+00:35:56,240 --> 00:36:01,820
+وعلى دماغها دائما في و هو و هي بنضم الهاء إذا كانت 
+
+288
+00:36:01,820 --> 00:36:05,220
+مضمومة و بنكسرها إذا كانت مكسورة، بنخليهاش ساكنة
+
+289
+00:36:05,220 --> 00:36:12,690
+بالمرة، لأن سكون الهاء لحن جالي، ليش طيب؟ لأن رواية
+
+290
+00:36:12,690 --> 00:36:16,510
+حفص فناصم بيضم لها، في عندنا رواية إمام الشعبة
+
+291
+00:36:16,510 --> 00:36:20,750
+بيسكن لها، بيقول و هو .. و هو عشان هيك لازم احنا
+
+292
+00:36:20,750 --> 00:36:25,850
+نضمها و نوضح .. ضمها عشان نبين قراءة حفص، يالا و
+
+293
+00:36:25,850 --> 00:36:30,650
+هو عليهم أنا ..
+
+294
+00:36:30,650 --> 00:36:34,970
+بعيد
+
+295
+00:36:34,970 --> 00:36:37,710
+.. ما سمعتش الدال بالمرة ياه ده، بعيد
+
+296
+00:36:42,200 --> 00:36:54,200
+بعيدة .. بعيدة
+
+297
+00:36:54,200 --> 00:36:58,760
+سبقت
+
+298
+00:36:58,760 --> 00:36:59,680
+من ربك
+
+299
+00:37:03,310 --> 00:37:21,870
+هذه الآية و لقد آتينا نفس
+
+300
+00:37:21,870 --> 00:37:28,790
+الاشي برضه مريب البقى الباقي و الدال من حروف إيش؟ طيب
+
+301
+00:37:28,790 --> 00:37:31,870
+من القلقة ليه المخرج؟ أول حرف من حروف القلقة لو
+
+302
+00:37:31,870 --> 00:37:36,430
+موقوف عليه إيش بيكون علناه؟ قال قلقة كبرى، طيب يا
+
+303
+00:37:36,430 --> 00:37:44,490
+.. وإنهم لفي شك إنه منكم غريب من عمل بارحانة لنفسه
+
+304
+00:37:44,490 --> 00:37:53,210
+ومن أساقف عليها وما ربك بيضل بالعجيب ليه اترل
+
+305
+00:37:53,210 --> 00:38:00,230
+الساعة وما تخرج من ثمرات من أكنامها وما تحملوا من 
+
+306
+00:38:00,230 --> 00:38:01,070
+كنت
+
+307
+00:38:18,750 --> 00:38:20,690
+الله يفتح عليهم.
+
+308
+00:38:23,330 --> 00:38:30,210
+بسم الله الرحمن الرحيم وضعنا عنهم ما كانوا يبقوا
+
+309
+00:38:50,210 --> 00:38:58,530
+خوني عنه ولا إذا دقناه رحمة منا لمنا
+
+310
+00:39:04,100 --> 00:39:12,980
+من بعد ضراء مسته من بعد ضراء على همزة فاتحة ضراء
+
+311
+00:39:12,980 --> 00:39:21,540
+مسته من بعد ضراء .. من بعد ضراء مسته ليقول أنها
+
+312
+00:39:21,540 --> 00:39:31,460
+ذالي وما أظن الساعة وما أظن الساعة قائمة أول أرجعت
+
+313
+00:39:31,460 --> 00:39:32,420
+إلى ربي
+
+314
+00:39:50,950 --> 00:39:56,090
+فننبأن .. فننبأن
+
+315
+00:39:56,090 --> 00:40:03,090
+.. فننبأن .. فننب .. فننب .. فننب .. فننب .. فننب
+
+316
+00:40:03,090 --> 00:40:03,410
+.. فننب .. فننب .. فننب .. فننب .. فننب .. فننب ..
+
+317
+00:40:03,410 --> 00:40:15,210
+فننب ..فلننبي أن .. كيف؟
+
+318
+00:40:15,210 --> 00:40:21,210
+فلننبي أن .. أحسنت،
+
+319
+00:40:21,210 --> 00:40:29,690
+كويس، حسنا يالله
+
+320
+00:40:29,690 --> 00:40:30,670
+يا يسرى
+
+321
+00:40:33,960 --> 00:40:40,020
+فلنبقى أن الذين تفروا بما عملوا و لنضيق أنهم من ..
+
+322
+00:40:40,020 --> 00:40:48,540
+و لنضيق أنهم من عذاب غليظ و إذا أنعمنا على إنسان
+
+323
+00:40:48,540 --> 00:40:55,180
+أعرض و نقى بجانبه و إذا مسه الشر و إذا مسه الشر
+
+324
+00:40:55,180 --> 00:41:07,850
+فده دعاء عريض عريض قل أرايتم أنجفش عنهم قل قرأيتم
+
+325
+00:41:07,850 --> 00:41:15,830
+إن كان من عيد الجنان من عيد الله من عيد الله ثم
+
+326
+00:41:15,830 --> 00:41:23,370
+كفرتم
+
+327
+00:41:23,370 --> 00:41:31,810
+به من أضلوا من أضلوا من من هو فيه
+
+328
+00:41:36,380 --> 00:41:47,100
+جيبت ده ليه كويس يا عزيزي؟ بعيد سنريهم
+
+329
+00:41:47,100 --> 00:41:55,780
+.. سنريهم آياتنا في الآفاق وفي أنفسهم حتى
+
+330
+00:41:55,780 --> 00:42:03,360
+.. في أنفسهم حتى تبين لهم .. يتبين لهم .. يتبين
+
+331
+00:42:04,970 --> 00:42:13,470
+وفي أنفسهم حتى يتبين لهم أنه الحق أولم يكفي برب
+
+332
+00:42:13,470 --> 00:42:23,210
+كأنه على كل شيء شهيد ألا إنهم في مرية .. مرية في
+
+333
+00:42:23,210 --> 00:42:30,300
+مريت يعني إيش حكم الرأهان؟سبقات بيكسر؟ مكسورة؟ لأ
+
+334
+00:42:30,300 --> 00:42:35,040
+هي مش مكسورة، هي ساكنة سبقات كسر
+
+335
+00:42:37,350 --> 00:42:44,350
+مش ضرورة ممكن تحضر بغي كده جالي الدكتور زاده .. هو
+
+336
+00:42:44,350 --> 00:42:50,430
+عطل بيجي ..معلش ..معلش ..مش
+
+337
+00:42:50,430 --> 00:42:55,350
+مش كده ..العادة ..العادة نرتاح و ندرس اللي جابتنا
+
+338
+00:42:55,350 --> 00:42:59,190
+..أنا مش نرتاح ..الله يطلع ..و الله هي ترمت حرام
+
+339
+00:42:59,190 --> 00:42:59,210
+..
+
+340
+00:43:05,060 --> 00:43:12,040
+أنا عارفين كمان .. خلاص طيب أنا بصدق وانتوا ..
+
+341
+00:43:12,040 --> 00:43:23,540
+معلش هتذكر يا أستاذ الجهاز؟ في مرية
+
+342
+00:43:26,830 --> 00:43:36,550
+هو في نوية .. في ملية من لقاء ربهم في نوية من لقاء
+
+343
+00:43:36,550 --> 00:43:46,650
+ربهم ألا إنه بكل شيء محيط .. محيط .. اقع .. محيط
+
+344
+00:43:46,650 --> 00:43:52,890
+.. هو في الطائرة يعني .. محيط .. محيط .. الله يفتح
+
+345
+00:43:52,890 --> 00:43:53,130
+علينا
+
+346
+00:43:57,930 --> 00:44:04,890
+أعوذ بالله من الشيطان الرجيم بسم الله الرحمن
+
+347
+00:44:04,890 --> 00:44:09,470
+الرحيم حاميم
+
+348
+00:44:09,470 --> 00:44:15,890
+.. لأ ح .. من حوف .. حيون طهر .. لازم ده .. حركتين
+
+349
+00:44:15,890 --> 00:44:23,980
+.. تكتب حرف واحد لكن تمد مقدار حركتين حاميم ..ميم
+
+350
+00:44:23,980 --> 00:44:33,240
+جدش مادناها وسط حركات ما اعرفش ready هي يعني حميم
+
+351
+00:44:33,240 --> 00:44:41,020
+تنزل الكتاب من الله العزيزي العليم غافر الذنب
+
+352
+00:44:41,020 --> 00:44:54,830
+وقابل التوبة غافر الذنب
+
+353
+00:44:54,830 --> 00:45:02,310
+و قابل التوبة شديد العقاب ذي الطول ذي الطول لا إله
+
+354
+00:45:02,310 --> 00:45:11,560
+إلا هو إليه المصير ما يجادل في آيات الله إلا الذين
+
+355
+00:45:11,560 --> 00:45:20,220
+كفروا، إلا الذين كفروا، فلا يغررك تقلبهم في البلاد
+
+356
+00:45:20,740 --> 00:45:28,260
+كذبت قبلهم قوم نوح .. كذبت قبلهم قوم نوح والأحزاب
+
+357
+00:45:28,260 --> 00:45:36,020
+.. والأحزاب من بعدهم وهمت كل أمة .. وهمت .. و
+
+358
+00:45:36,020 --> 00:45:44,620
+همت كل أمتهم برسولهم ليأخذوه وجادلوا بالباطل
+
+359
+00:45:44,620 --> 00:45:55,020
+ليُضَحِّضُوا
+
+360
+00:45:55,020 --> 00:46:03,240
+به الحق فأخذتهم فكيف كان عقابهم؟ وكذلك حقت كلمة ربك
+
+361
+00:46:03,240 --> 00:46:12,590
+على الذين كفروا أنهم أصحاب النار الذين يحملون العرش
+
+362
+00:46:12,590 --> 00:46:19,710
+ومن حوله يسبحون
+
+363
+00:46:19,710 --> 00:46:28,100
+بحمد ربهم يسبحون بحمد ربهم ويؤمنون به ويستغفرون
+
+364
+00:46:28,100 --> 00:46:35,820
+للذين آمنوا ربنا وسعت كل شيء .. وسعت كل شيء .. و
+
+365
+00:46:35,820 --> 00:46:41,220
+سعت كل شيء رحمته .. لأ ما تعملش غناء .. شيء رحمته
+
+366
+00:46:41,220 --> 00:46:48,790
+وعلمه .. كل شيء رحمته وعلمه فاخفر للذين تابوا
+
+367
+00:46:48,790 --> 00:46:55,710
+فاخفر .. فاخفر للذين ساكنة ساكنة .. ساكنة لكن إيه؟
+
+368
+00:46:55,710 --> 00:47:00,750
+مسبوقة؟ بتكسر؟ فاخفر للذين تابوا واتبعوا سبيلك
+
+369
+00:47:00,750 --> 00:47:04,890
+واطهم عذابهم واتبعوا سبيلك واتبعوا سبيلك .. في
+
+370
+00:47:04,890 --> 00:47:08,810
+الناس حروف المد نخطفها خطف ونضيع الحركتين واتبعوا
+
+371
+00:47:08,810 --> 00:47:16,020
+.. الواو .. واتبعوا سبيلك واتبعوا سبيلك واطهم عذاب
+
+372
+00:47:16,020 --> 00:47:27,760
+الجحيم ربنا وأدخلهم جنات عدن التي وعدتهم ومنصا
+
+373
+00:47:27,760 --> 00:47:38,160
+ومن صلح من آبائهم وأزواجهم وذرياتهم إنك أنت العزيز
+
+374
+00:47:38,160 --> 00:47:44,300
+الحكيم الله يفتح علينا اقرأ يعني بسم الله الرحمن
+
+375
+00:47:44,300 --> 00:47:52,500
+الرحيم وقيم السيئات ومن تق السيئات يومئذ فقد رحمته
+
+376
+00:47:52,500 --> 00:48:01,020
+فقد رحمته فقد رحمته وذلك هو الفوز العظيم إن الذين
+
+377
+00:48:01,020 --> 00:48:07,440
+كفروا نادونا .. نادونا .. إن الذين كفروا نادونا
+
+378
+00:48:07,440 --> 00:48:12,830
+مفهو الله أفضل لما اطلع يأكبر مني مقتكم .. مني
+
+379
+00:48:12,830 --> 00:48:19,130
+مقتكم أو نفسكم أَتَدْعُونَ
+
+380
+00:48:19,130 --> 00:48:24,590
+إلى الإيمان فَتَكْفُرُونَ أنتم ادعونا إلى الإيمان
+
+381
+00:48:24,590 --> 00:48:31,270
+بتكفرون قالوا ربنا أمانتنا اتنتين و احنايتنا
+
+382
+00:48:31,270 --> 00:48:38,070
+واحنايتنا اتنتين فأطرفنا ببنوقنا ثاني أخرج من
+
+383
+00:48:38,070 --> 00:48:42,290
+السبيل ذلك بأنه
+
+384
+00:48:48,750 --> 00:48:56,930
+ذلكم بأنه إذا دعي الله .. إذا دعي الله وحده كفرتم
+
+385
+00:48:56,930 --> 00:49:02,910
+وإي يشرق به تؤمنوا .. كف ساكنة وإي يشرق به تؤمنوا
+
+386
+00:49:02,910 --> 00:49:08,630
+.. وإي يشرق به ت .. وإي يشرق به تؤمنوا فالحكم إلا
+
+387
+00:49:08,630 --> 00:49:16,140
+العلي الكبير .. الكبير .. العلي الكبير هو الذي
+
+388
+00:49:16,140 --> 00:49:23,520
+يريكم آياته .. هو الذي يريكم آياته وينزل لكم ..
+
+389
+00:49:23,520 --> 00:49:28,180
+وينزل .. وينزل لكم .. وينزل .. وينزل لكم .. وينزل
+
+390
+00:49:28,180 --> 00:49:33,860
+لكم .. وينزل لكم .. وينزل لكم من السماء لسقى وما
+
+391
+00:49:33,860 --> 00:49:40,200
+يتذكر منا مينين و أنا بتغامي إيمان إلا مينين وما
+
+392
+00:49:40,200 --> 00:49:47,060
+يتذكر منا مينين فادعو الله مخلصين لو ابتدوا ولو كره
+
+393
+00:49:47,060 --> 00:49:54,820
+الكافرون رفيع الدرجة تدلعش يلقى الروح منه يلقى
+
+394
+00:49:54,820 --> 00:49:59,940
+الروح من أمره على .. يلقى الروح من أمره على من
+
+395
+00:49:59,940 --> 00:50:05,060
+يشاء على من يشاء
+
+396
+00:50:05,060 --> 00:50:12,430
+من عباده ليوضع يوم التلاعبيوم هم بارزونا .. يوم هم
+
+397
+00:50:12,430 --> 00:50:21,110
+بارزونا .. يوم هم بارزونا .. يوم هم بارزونا .. يوم
+
+398
+00:50:21,110 --> 00:50:25,810
+هم بارزونا .. يوم هم بارزونا .. يوم هم بارزونا ..
+
+399
+00:50:25,810 --> 00:50:32,250
+لا يفع الله منهم شيء .. منهم شيء .. منهم شيء ..
+
+400
+00:50:32,250 --> 00:50:38,650
+لمنهم كل يوم لله .. لمنهم كل يوم لله واحد بقى الله
+
+401
+00:50:38,650 --> 00:50:47,330
+يفتح عليك، يا ناصر بسم الله الرحمن الرحيم اليوم
+
+402
+00:50:47,330 --> 00:50:53,550
+أتجزأ من كل نفسي لأنها كتبت يوم الآزفة التي ذي القلوب
+
+403
+00:50:53,550 --> 00:50:56,930
+وأنذرهم
+
+404
+00:50:56,930 --> 00:51:05,890
+يوم الآزفة التي يوم الآزفة التي ذي القلوب أَسْرَعُ قَرَآيَا
+
+405
+00:51:05,890 --> 00:51:13,290
+الصابرين وأنذرهم الرأس ساكنة سبقت بتكسر، إيش حكمها؟
+
+406
+00:51:13,290 --> 00:51:14,190
+مرقق .. مرققية
+
+407
+00:51:19,890 --> 00:51:41,930
+لدي .. لدى الحنادق يدعونا
+
+408
+00:51:42,920 --> 00:51:47,640
+يبيعونا من ضمنه وإنما لو تجدوا لي لا يقولون شيء
+
+409
+00:51:47,640 --> 00:51:54,480
+أنه هو السميع البصير أو لم يسيروا في الأرض فينظروا
+
+410
+00:51:54,480 --> 00:51:58,400
+كيف كان عقبة الذين كانوا من قبلهم 
+
+411
+00:52:04,300 --> 00:52:12,860
+كانهم أشد من قوتهم وأدوى في الأرض فأخذه الله بِدُونِهِمْ
+
+412
+00:52:12,860 --> 00:52:20,000
+فأخذه الله بِدُونِهِمْ فأخذه الله بِدُونِهِمْ وما كان لهم من
+
+413
+00:52:20,000 --> 00:52:28,430
+الطاقم ودانهم .. الله يفتح علي كان لي عارف بسم الله
+
+414
+00:52:28,430 --> 00:52:35,350
+الرحمن الرحيم قرأت يا روانضة؟ yeah .. ذلك بأنهم
+
+415
+00:52:35,350 --> 00:52:40,470
+كانت تأتيهم رسلهم بالبينات فكفروا .. برضه بالفعل
+
+416
+00:52:40,470 --> 00:52:44,270
+شفتوا يا ماريا رسلهم بالبينات
+
+417
+00:52:45,660 --> 00:52:53,540
+ذلك بأنه كانت تأتيهم رسلهم بالبينات فَجَعَلُوا فأخذهم
+
+418
+00:52:53,540 --> 00:53:08,280
+الله إنه قوي شديد العقاب و لقد أرسلنا موسى بآياتنا
+
+419
+00:53:08,280 --> 00:53:18,600
+وسلطة مبين إلى فرعون و هامان و قارون .. وقارون ..
+
+420
+00:53:18,600 --> 00:53:27,720
+إلى فرعون و هامان و قارون فقالوا ساخر مكذاب فلمّا
+
+421
+00:53:27,720 --> 00:53:35,740
+جاءهم بالحق من عندنا قالوا اقتلوا .. قالوا اقتلوا
+
+422
+00:53:36,000 --> 00:53:51,740
+أبناء الذين آمنوا معه 
+
+423
+00:53:51,740 --> 00:54:00,840
+واستحيوا نساءهم وما كيد الكافرين إلا في ضلال وقال
+
+424
+00:54:00,840 --> 00:54:10,540
+فرعون وقال فرعون ذروني أقاتل موسى اقتل 
+
+425
+00:54:10,540 --> 00:54:21,780
+موسى وليدعو ربه إني أخاف أن يبدل دينكم إني أخاف أن
+
+426
+00:54:21,780 --> 00:54:28,940
+يبدل دينكم أو أن .. أو أن يضجر في الأرض الفساد
+
+427
+00:54:28,940 --> 00:54:35,020
+وقال موسى إني عُدتُ بربي وربكم
+
+428
+00:54:56,660 --> 00:54:59,920
+علي صوتك يعني علي صوتك شوية
+
+429
+00:55:05,570 --> 00:55:09,690
+من آل فرعون
+
+430
+00:55:09,690 --> 00:55:16,730
+من آل فرعون يكتموا إيمانه وتقتلونا من آل فرعون 
+
+431
+00:55:16,730 --> 00:55:23,530
+يكتموا إيمانه تقتلونا جيبلي مادة الصلاة الكبرى 
+
+432
+00:55:23,530 --> 00:55:25,090
+تقتلونا
+
+433
+00:55:34,250 --> 00:55:42,930
+رجلًا عندك من فترة رجلًا أي يقول رجلًا
+
+434
+00:55:42,930 --> 00:55:49,890
+.. رجلًا .. رجلًا .. رجلًا أي يقول ربي الله ومجا
+
+435
+00:55:49,890 --> 00:55:56,710
+أكَم بالبينات جاء أكَم بالبينات ومجا أكَم بالبينات من
+
+436
+00:55:56,710 --> 00:56:03,510
+ربكم وإيه كابّه فعليه كابّه وإيه كابّه فعليه كابّه
+
+437
+00:56:10,150 --> 00:56:24,490
+كذبوه وإي يكون صادق أيصركم بعضه
+
+438
+00:56:24,490 --> 00:56:32,590
+بعض الذي يعيدكم يعيدكم 
+
+439
+00:56:33,860 --> 00:56:42,720
+أنت الله لا يدي من هو مصرفًا كذاب كذاب كذاب يا قومي
+
+440
+00:56:42,720 --> 00:56:47,920
+لكم يوم اليوم ماضيين في الأرض فمن ينصرنا من فأس 
+
+441
+00:56:47,920 --> 00:56:57,540
+الأنجان بس أوصل أوصل فمن ينصرنا فمن ينصرنا من فأس
+
+442
+00:56:57,540 --> 00:57:20,470
+الأنجان قالت العوزما أريكم أخافوا
+
+443
+00:57:29,720 --> 00:57:39,700
+مثل .. وما 
+
+444
+00:57:39,700 --> 00:57:45,700
+الله يريده 
+
+445
+00:57:45,700 --> 00:57:52,680
+الله يفتح حاله .. كان بيا فات .. أفادوهبسم الله
+
+446
+00:57:52,680 --> 00:58:01,060
+الرحمن الرحيم ويا قوم إني أخاف عليكم يوم التناد
+
+447
+00:58:01,060 --> 00:58:08,220
+يوم تولون مدبرين مالكم من الله من عاصٍ .. من عاصٍ 
+
+448
+00:58:08,220 --> 00:58:16,980
+يوم تولون مدبرين مالكم من الله من عاصٍ ومن يظلل الله
+
+449
+00:58:16,980 --> 00:58:19,200
+فما له من ناصر 
+
+450
+00:58:22,510 --> 00:58:30,170
+ولقد جاءكم يوسف من قبل بالبينات فما زلتم .. فما
+
+451
+00:58:30,170 --> 00:58:41,250
+زلتم في شك مما جاءكم به حتى إذا هلك قلتم ليبعث 
+
+452
+00:58:41,250 --> 00:58:48,930
+الله ليبعث الله  لا قلتم .. قلتم عشان تدا .. تدا مش 
+
+453
+00:58:48,930 --> 00:58:51,230
+قبيح قلتم ليبعث الله
+
+454
+00:59:09,600 --> 00:59:13,280
+بغير سلطان أتاهم 
+
+455
+00:59:17,160 --> 00:59:19,940
+يغير سلطان أتاهم .. مافيش ما أتىهم هم زي القطع أو
+
+456
+00:59:19,940 --> 00:59:27,380
+الكلمة يغير سلطان أتاهم يغير سلطان أتاهم كبر مقتل
+
+457
+00:59:27,380 --> 00:59:35,520
+عند الله وعند الذين آمنوا كذلك يقطع الله على كل
+
+458
+00:59:35,520 --> 00:59:44,950
+قلب متكبر جباه وقال فرعون ياوقال فرعونه رقيق الرقم
+
+459
+00:59:44,950 --> 00:59:51,330
+وقال فرعونه يا هامل ابنيلي صرحًا لعلي أبلغ ال ..
+
+460
+00:59:51,330 --> 01:00:01,330
+لعلي أبلغ الأسباب الله يفتح عليك قلتيش؟ أسباب
+
+461
+01:00:01,330 --> 01:00:07,050
+.. أسباب .. أسباب السلامات فأطيع .. فأطيع
+
+462
+01:00:09,640 --> 01:00:16,900
+فأطلع إلى إله
+
+463
+01:00:16,900 --> 01:00:28,920
+موسى إلى إله موسى، مافيش يا إله إلى إله موسى، 
+
+464
+01:00:28,920 --> 01:00:32,100
+مش إله، إلى إله موسى
+
+465
+01:00:34,690 --> 01:00:45,130
+فأفضر على إلهه إله .. إله وإني لأظنه كذبة لأظنه
+
+466
+01:00:45,130 --> 01:00:56,910
+كاذبة وإني لأظنه كاذبة لأظنه وإني لأظنه .. لأظنه
+
+467
+01:00:56,910 --> 01:01:05,680
+كاذبة وكذلك زي .. وكذلك زي .. وكذلك زي ..زينا
+
+468
+01:01:05,680 --> 01:01:15,680
+لفرعون .. زينا .. فيش قلنا عليها شدة؟ زينا زينا 
+
+469
+01:01:15,680 --> 01:01:21,900
+لفرعون سوء
+
+470
+01:01:21,900 --> 01:01:22,580
+عمله 
+
+471
+01:01:28,100 --> 01:01:37,020
+و جيبي المادة .. جيبي المادة المقتصرة سوقوا و
+
+472
+01:01:37,020 --> 01:01:39,380
+خد ده 
+
+473
+01:01:44,150 --> 01:01:53,170
+وصد عن السبيل وما 
+
+474
+01:01:53,170 --> 01:02:02,330
+كيدوا فرعون إلا في تمام وقال الذي آمن يا قوم 
+
+475
+01:02:02,330 --> 01:02:08,670
+اتبعونه تابعوني أهديكم وقال الذي آمن يا قوم
+
+476
+01:02:08,670 --> 01:02:09,730
+اتبعونه
+
+477
+01:02:11,890 --> 01:02:22,110
+تبعوني أهديكم سبيل
+
+478
+01:02:22,110 --> 01:02:28,330
+الرشاد واضح الدال عشان فيها صوت القلق لابد أن أنا
+
+479
+01:02:28,330 --> 01:02:40,490
+أوّضحها سبيل الرشاد لأ برضه مش مبينةالرشادة تبيل
+
+480
+01:02:40,490 --> 01:02:50,090
+الرشاد
+
+481
+01:02:50,090 --> 01:02:53,930
+يا قوم 
+
+482
+01:02:53,930 --> 01:02:58,490
+إنما هذه الحياة الدنيا متاعها 
+
+483
+01:03:15,320 --> 01:03:17,820
+ما يفتح عليه؟ 
+
+484
+01:03:32,260 --> 01:03:42,080
+اقراي يا لينا يا تمي جاني ليلًا
+
+485
+01:03:42,080 --> 01:03:47,160
+جرب ولّا قدامي مش عشان أسمع صوتك صوتك واضح الله
+
+486
+01:03:47,160 --> 01:03:53,240
+يبارك فيك الله
+
+487
+01:03:53,240 --> 01:04:00,740
+يرضى عاملك يا عزيزي من عاملة؟من عاملة سيئة فلا
+
+488
+01:04:00,740 --> 01:04:11,820
+يُجزى من عاملة سيئة فلا يُجزى من عاملة سيئة فلا
+
+489
+01:04:11,820 --> 01:04:22,320
+يُجزى من عاملة سيئة فلا يُجزى إلا مثلها إلا مثلها
+
+490
+01:04:22,320 --> 01:04:26,500
+ومن
+
+491
+01:04:26,500 --> 01:04:27,880
+عاملة صالحة
+
+492
+01:04:31,240 --> 01:04:37,700
+أو أن ثا .. جبتي الاتفاق بجيبي حركتان أو أن ثا ..
+
+493
+01:04:37,700 --> 01:04:46,280
+و هو مؤمن .. و هو مؤمن فأولئك يدخلون الجنة مدّ
+
+494
+01:04:46,280 --> 01:04:52,900
+المدّ فأولئك .. ايش نوع المد هنا؟ مدٌّ مدٌّسة .. مدٌّسة 
+
+495
+01:04:52,900 --> 01:04:56,940
+.. و هي مدٌّسة .. و هي مدٌّسة .. كلهم مغسسون
+
+496
+01:05:00,000 --> 01:05:08,020
+فأولئك يدخلون الجنة يرزقون .. اغني
+
+497
+01:05:08,020 --> 01:05:16,440
+عنهم يدخلون الجنة يدخلون الجنة يرزقون .. يرزقون 
+
+498
+01:05:16,440 --> 01:05:23,500
+فيها بغير حساب ويا قوم ما لي أدعوكم .. ما لي
+
+499
+01:05:23,500 --> 01:05:25,360
+أدعوكم 
+
+500
+01:05:28,840 --> 01:05:37,360
+لأ .. لأ أقرأي كويس كمان و يا قوم ما لي أدعوكم إلى
+
+501
+01:05:37,360 --> 01:05:44,980
+النجاة و تدعوني .. إلى النجاة إلى النجاة و تدعوني
+
+502
+01:05:44,980 --> 01:05:54,760
+.. و تدعونني إلى .. و تدعونني إلى النار إلى النار
+
+503
+01:05:57,660 --> 01:06:03,220
+مش النار الالف ايه حكمها؟ مراقخة ولا مفخمة؟ مراقخة
+
+504
+01:06:03,220 --> 01:06:10,380
+اه، مناشي نقول النار، غلط إلى النار إلى النار
+
+505
+01:06:10,380 --> 01:06:18,900
+تدعونني لأكفر ما تدعونني لأكفر تدعونني
+
+506
+01:06:18,900 --> 01:06:24,080
+لأكفر بالله و أشرك به ما ليس بِه بِه أوصلي ..
+
+507
+01:06:24,080 --> 01:06:29,650
+أوصلي و أشرك به ما ليس فِقشت بِه ما ليس .. ما ليس لي
+
+508
+01:06:29,650 --> 01:06:36,470
+بِه علم و أنا .. و أنا .. و أنا أدعوكم الإدغام ثابتة
+
+509
+01:06:36,470 --> 01:06:40,450
+في حال الرسم العثماني وعند إيه؟ وعند الوصل لكن 
+
+510
+01:06:40,450 --> 01:06:44,250
+.. و عند الوقف لكن عند الوصل و أنا أدعوكم، لا
+
+511
+01:06:44,250 --> 01:06:50,610
+تلفظت لعزيزي الغفار، لا جرم إنما .. لا جرم .. لا 
+
+512
+01:06:50,610 --> 01:06:59,990
+جرم إنما تدعونني .. لا جرم ..أنما .. لا جرم إنما
+
+513
+01:06:59,990 --> 01:07:07,390
+تدعونني إليه .. تدعونني إليه ليس لو دعوة في الدنيا
+
+514
+01:07:07,390 --> 01:07:15,510
+ولا في الآخرة وإنما .. وأنما ردنا .. وأنما ردنا
+
+515
+01:07:15,510 --> 01:07:25,150
+إلى الظالمين وأنما ..وأن المسرحين هم .. هم أصحاب
+
+516
+01:07:25,150 --> 01:07:30,170
+النار .. هم أصحاب النار، الله يفتح عليه
+
+517
+01:07:35,230 --> 01:07:42,330
+الله الرحمن الرحيم فستذكرون ما أقول لكم وفَقَدَ أمري
+
+518
+01:07:42,330 --> 01:07:49,790
+إلى الله إن الله بصيرٌ للعباد فوقاب الله سيئات ما
+
+519
+01:07:49,790 --> 01:07:54,150
+مكروا وحاق بآلة لعون سوء العذاب
+
+520
+01:07:56,390 --> 01:08:02,490
+وحاق بقال في رعونة سوء العذاب .. سوء العذاب مضمون
+
+521
+01:08:02,490 --> 01:08:07,110
+أنه نار يُعرضون عليها ويوم الصبح عشية .. الرأس
+
+522
+01:08:07,110 --> 01:08:12,820
+مضمون لازم نفخنها أن ناره يُعرضون النار يُعرضون
+
+523
+01:08:12,820 --> 01:08:19,760
+عليها بدوا وعشي يوم ويوم تقوم الساعة ويوم تقوم
+
+524
+01:08:19,760 --> 01:08:24,000
+الساعة ويوم 
+
+525
+01:08:24,000 --> 01:08:27,440
+تقوم الساعة
+
+526
+01:08:27,440 --> 01:08:33,600
+ويوم تقوم الساعة تدخلوا أدخلوا نمشد العدو ويوم 
+
+527
+01:08:33,600 --> 01:08:47,980
+تقوم الساعة تدخلوا نمشد العدوو يوم تقوم الساعة
+
+528
+01:08:47,980 --> 01:08:57,280
+و ادخلوا آل فرعون عشان ده العذاب
+
+529
+01:09:20,260 --> 01:09:29,270
+دي بالإضاءة حركتين أنتم مغنونةفهل أنتم مغنون عن
+
+530
+01:09:29,270 --> 01:09:35,870
+نصيبكم من النار؟ قولني عنه يعني من النار قال الذين 
+
+531
+01:09:35,870 --> 01:09:44,730
+.. من النار من النار قال الذين استكبروا إن كلهم
+
+532
+01:09:44,730 --> 01:09:50,950
+فيها إن الله قد حكم بين العباد الله يفتح عليك كمية 
+
+533
+01:09:50,950 --> 01:09:59,100
+أحلى أعوذ بالله من الشيطان الرجيم، وقال الذين في
+
+534
+01:09:59,100 --> 01:10:08,790
+تاني خزنة جهنم ادعوا ربهم يطفف عنهم ادعوا ربكم يقفز
+
+535
+01:10:08,790 --> 01:10:18,070
+عنا يوما يتعذابك قالوا أولم تآتيكم
+
+536
+01:10:18,070 --> 01:10:26,290
+رسولكم بالبينات قالوا بلى قالوا فدعوا ما 
+
+537
+01:10:26,290 --> 01:10:36,570
+دعاء الكافرين إلا في ضلال إننا لن .. إننا لن نصر .. 
+
+538
+01:10:36,570 --> 01:10:42,570
+رسولنا .. إننا
+
+539
+01:10:42,570 --> 01:10:48,870
+لن نصر رسولنا والذين آمنوا في الحياة الدنيا ويوم
+
+540
+01:10:48,870 --> 01:10:55,830
+يقوموا الأشهاد يوم لا ينفعوا الظالمين معدى ربهم
+
+541
+01:10:55,830 --> 01:11:02,510
+ولهم اللعنة ولهم سوء الله يفتح عليك، خليني أنا أقف
+
+542
+01:11:02,510 --> 01:11:05,530
+عن هذا الموضوع عشان ده تبدأ قصة سيدنا موسى عليه 
+
+543
+01:11:05,530 --> 01:11:08,710
+السلام، الله يفتح عليكم، برك الله فيكم، سبحان 
+
+544
+01:11:08,710 --> 01:11:11,410
+الله، هم أبو حمد كاشر ولا إله إلا؟ 
diff --git a/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY_postprocess.srt b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY_postprocess.srt
new file mode 100644
index 0000000000000000000000000000000000000000..01b9ebaae0cb0cb6a10ecfa77422f76ac8bcf8ed
--- /dev/null
+++ b/PL9fwy3NUQKwbfMrmJBRbdEavuwd9NDKwu/zAu9ObYpSQY_postprocess.srt
@@ -0,0 +1,2176 @@
+1
+00:00:11,620 --> 00:00:14,480
+أعوذ بالله السماء العليا من الشيطان الرجيم بسم
+
+2
+00:00:14,480 --> 00:00:18,160
+الله الرحمن الرحيم الصلاة والسلام على سيد المرسلين
+
+3
+00:00:18,160 --> 00:00:26,560
+وعلى أهله و آله أجمعين أما بعدمجهزين يا أخوان؟
+
+4
+00:00:26,560 --> 00:00:31,000
+يالله يا بسمة، توكر يا الله صورة الشورى، الآية 32
+
+5
+00:00:31,000 --> 00:00:37,420
+ومن آياته الجوارف البحر كالأعلام أعوذ بالله السميع
+
+6
+00:00:37,420 --> 00:00:45,920
+العليم من الشيطان الرجيم بسم الله الرحمن الرحيم
+
+7
+00:00:45,920 --> 00:00:55,870
+ومن آياته الجوارف البحر كالأعلامإن يشأ يسكن الريح
+
+8
+00:00:55,870 --> 00:01:05,010
+فيظللنا رواكر فيظللنا رواكر على ظهره إن في ذلك
+
+9
+00:01:05,010 --> 00:01:09,950
+لآيات لكل صبار شكوه
+
+10
+00:01:12,270 --> 00:01:16,370
+أو يبقهن بما كسبوا .. قف ساكنة .. قف ساكنة يعني،
+
+11
+00:01:16,370 --> 00:01:21,910
+بس ما .. خليها ساكنة أو يبقهن .. أو يبقهن بما
+
+12
+00:01:21,910 --> 00:01:29,090
+كسبوا ويعفوا عن كثير كثير، إيش حكم الرأهان؟ مرقق،
+
+13
+00:01:29,090 --> 00:01:30,970
+مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق،
+
+14
+00:01:30,970 --> 00:01:32,470
+مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق، مرقق،
+
+15
+00:01:32,470 --> 00:01:40,190
+مرقق، مرقق، مرقق، مرقق
+
+16
+00:01:41,420 --> 00:01:53,480
+ويعلم الذين يجادلون في آياتنا ما لهم من محيص فما
+
+17
+00:01:53,480 --> 00:02:05,690
+أوتيتهم من شيء فمتاع الحياة الدنياوما عند الله خير
+
+18
+00:02:05,690 --> 00:02:16,770
+وأبقى للذين آمنوا وعلى ربهم يتوكلون والذين يجتنبون
+
+19
+00:02:16,770 --> 00:02:24,890
+كبائر الإثم والفواحش وإذا ما غضبوا .. وإذا ما
+
+20
+00:02:24,890 --> 00:02:30,190
+غضبوا هم يغفرون الله يفتح عليك، اقرأ يا سزان
+
+21
+00:02:40,050 --> 00:02:48,810
+والذين استجابوا لربهم وأقاموا الصلاة وأمروا
+
+22
+00:02:48,810 --> 00:02:57,010
+مشورة بينهم ومما رزقناهم ينفقون
+
+23
+00:02:57,010 --> 00:03:01,090
+والذين
+
+24
+00:03:01,090 --> 00:03:01,730
+إذا
+
+25
+00:03:06,870 --> 00:03:18,530
+والليل إذا أصابهم البغيهم
+
+26
+00:03:18,530 --> 00:03:25,850
+ينتصرون هم ينتصرون عيبا، إيش الحكم هان؟ تبع تبع
+
+27
+00:03:29,940 --> 00:03:43,080
+وجزاء سيئة وجزاء سيئة وجزاء سيئة سيئة مثلها تمنعف
+
+28
+00:03:43,080 --> 00:03:50,160
+وأصلح فأجره فأجره على الله أجره رأم ضمون فأجره على
+
+29
+00:03:50,160 --> 00:03:59,040
+الله إنه لا يحب الظالمينولا .. ولا من انتصر بعد ..
+
+30
+00:03:59,040 --> 00:04:01,540
+ولا من .. برضه الإخساط، ليش ده ما اللي بتنسوا
+
+31
+00:04:01,540 --> 00:04:10,280
+الإخساط انتوا؟ إيش حروف الإخساط عندنا؟ هايك
+
+32
+00:04:10,280 --> 00:04:12,800
+وشاطريه، نطبق النظر اللي أخدنا على العمل اللي
+
+33
+00:04:12,800 --> 00:04:19,640
+معانا، يلا و لا .. ولا من انتصر بعد غلمه فأولئك ..
+
+34
+00:04:19,640 --> 00:04:23,580
+بعد غلمه فأولئك
+
+35
+00:04:30,060 --> 00:04:35,640
+برضه الإخفاء يا سوزان من سبيل .. إخفاء لكن أجرح
+
+36
+00:04:35,640 --> 00:04:42,890
+إيه؟ في كلمتين يلّاإنما .. إنما السبيل على الذين
+
+37
+00:04:42,890 --> 00:04:48,090
+يظلمون الناس ويبغون في ال .. ويبغون في ال .. دائما
+
+38
+00:04:48,090 --> 00:04:53,710
+أصل يا أخوات، يظلمون الناس ويبغون في الأرض، أصل
+
+39
+00:04:53,710 --> 00:05:00,220
+لأن المعنى مترابطإنما السبيل على الذين يظلمون
+
+40
+00:05:00,220 --> 00:05:07,680
+الناس ويبقون في الأرض بغير الحق أولئك لهم عذاب
+
+41
+00:05:07,680 --> 00:05:12,220
+أليم ولمن
+
+42
+00:05:12,220 --> 00:05:25,520
+صبر وغفر إن ذلك لمن عزم الأمور ومن يظلم
+
+43
+00:05:26,020 --> 00:05:35,940
+ومن يضل الله فما له من وليه من .. من وليه
+
+44
+00:05:35,940 --> 00:05:44,600
+من بعده و ترى الظالمين لما رأوا العذاب يقولون هل
+
+45
+00:05:44,600 --> 00:05:49,860
+.. يقولون هل إلى .. هل إليه مرد من سبيل .. يقولون
+
+46
+00:05:49,860 --> 00:05:55,020
+هل إلى مرد من سبيل
+
+47
+00:05:59,040 --> 00:06:15,260
+الله يفتح عليك قرأ أيه دين؟ نعم يالا
+
+48
+00:06:15,260 --> 00:06:18,880
+و
+
+49
+00:06:18,880 --> 00:06:19,460
+تراهم
+
+50
+00:06:24,670 --> 00:06:31,190
+يعرضون عليها خاشعين من الذل .. خاشعين من الذل
+
+51
+00:06:31,190 --> 00:06:39,470
+ينظرون من طرف .. من طرفهم طرف خفي من طرف خفي .. من
+
+52
+00:06:39,470 --> 00:06:47,750
+طرف خفي .. خ .. خفي وقال الذين آمنواإن الخاسرين ..
+
+53
+00:06:47,750 --> 00:06:51,550
+وين المد؟ إن الخاسرين .. إيش نوع المد ده يا دينا؟
+
+54
+00:06:51,550 --> 00:06:55,750
+حكم المد .. أمن و مع إن .. أمن و مع إن .. إيش نوع
+
+55
+00:06:55,750 --> 00:06:59,130
+المد؟ حكم المد المفصل .. حكم المد المفصل .. حكم
+
+56
+00:06:59,130 --> 00:06:59,990
+المد المفصل .. حكم المد المفصل .. حكم المد المفصل
+
+57
+00:06:59,990 --> 00:07:01,170
+.. حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+58
+00:07:01,170 --> 00:07:03,290
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+59
+00:07:03,290 --> 00:07:06,610
+حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+60
+00:07:06,610 --> 00:07:10,270
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+61
+00:07:10,270 --> 00:07:10,650
+حكم المد المفصل .. حكم المد المفصل .. حكم المد
+
+62
+00:07:10,650 --> 00:07:11,110
+المفصل .. حكم المد المفصل .. حكم المد المفصل ..
+
+63
+00:07:11,110 --> 00:07:22,080
+حكم المد المفصلارجعي و قال الذين .. أيوة الذين
+
+64
+00:07:22,080 --> 00:07:32,180
+خسروا أنفسهم أنفسهم
+
+65
+00:07:32,180 --> 00:07:41,260
+وأهليهموأهليهم يوم القيامة ألا أن الظالمين في عذاب
+
+66
+00:07:41,260 --> 00:07:49,460
+مقيم وما
+
+67
+00:07:49,460 --> 00:07:55,820
+كان لهم من أولياء
+
+68
+00:07:55,820 --> 00:08:04,740
+ينصرونهممن أولياء ينصرون هم من دون الله ومي يضب
+
+69
+00:08:04,740 --> 00:08:11,920
+الله فالله فما له من سبيل فما له .. فما له من سبيل
+
+70
+00:08:11,920 --> 00:08:19,520
+من سبيل استجيبوا .. استجيبوا .. استجيبوا لربكم
+
+71
+00:08:19,520 --> 00:08:26,580
+استجيبوا لربكم من قبل أي يأتي يوم لهم أي يأتي يه
+
+72
+00:08:26,580 --> 00:08:27,900
+اليه مفتوحة
+
+73
+00:08:32,650 --> 00:08:40,030
+لا مارد له .. مارد له من الله ما لكم من .. من ملجأ
+
+74
+00:08:40,030 --> 00:08:44,770
+يومئذ .. جيب الإضغام حركتان يا دينا من ملجأ .. من
+
+75
+00:08:44,770 --> 00:08:55,110
+ملجأ يومئذ .. يومئذ و ما لكم من ..من كيل .. يالا
+
+76
+00:08:55,110 --> 00:09:06,690
+يا رانا الله يفتح عليك إن
+
+77
+00:09:06,690 --> 00:09:16,050
+.. النون مخففة أدقنا
+
+78
+00:09:16,050 --> 00:09:17,410
+لإنسان
+
+79
+00:09:19,560 --> 00:09:28,600
+إن رحمة فارح بها وإن تصدهم سيئة بما قدمت أيديهم
+
+80
+00:09:28,600 --> 00:09:34,940
+فإن الإنسان كفور لله جمهور السماوات والأرض
+
+81
+00:09:52,570 --> 00:09:55,350
+مي شاء
+
+82
+00:10:02,430 --> 00:10:09,650
+رقق الرأي يا راني قدير .. قدر
+
+83
+00:10:09,650 --> 00:10:13,690
+هي
+
+84
+00:10:13,690 --> 00:10:17,190
+يكلمه او
+
+85
+00:10:21,520 --> 00:10:27,260
+أو بوراء حجاب .. حجاب او يرسل .. او يرسل رسولة او
+
+86
+00:10:27,260 --> 00:10:32,840
+يرسل رسولة او يرسل رسولة فيوحي .. فيوحي بإذنه ما
+
+87
+00:10:32,840 --> 00:10:42,420
+يشاء إنه علي حكيم الله يفتح عليه طريقة حلوة أعوذ
+
+88
+00:10:42,420 --> 00:10:49,280
+بالله من الشيطان الرجيم وكذلك أوحيناو كذلك أوحينا
+
+89
+00:10:49,280 --> 00:10:55,620
+إليك روحا من أمرنا ماكنت تدري ما الكتاب ولا
+
+90
+00:10:55,620 --> 00:11:06,160
+الإيمان ولكن
+
+91
+00:11:06,160 --> 00:11:07,120
+رجعنا
+
+92
+00:11:12,030 --> 00:11:15,810
+و أنا المادة، المادة المقتصرة
+
+93
+00:11:39,160 --> 00:11:40,720
+الله يفتح عليك
+
+94
+00:11:49,880 --> 00:12:01,500
+عزيزي من الرحمن الغربي إذا قصيت آياته قصانا عربيا
+
+95
+00:12:01,500 --> 00:12:05,640
+عربيا لقوم يعلمها
+
+96
+00:12:17,200 --> 00:12:27,720
+والخلوقنا في أكنة
+
+97
+00:12:27,720 --> 00:12:38,800
+والخلوقنا في أكنة مما تدعونا مما تدعونا
+
+98
+00:12:43,120 --> 00:12:54,740
+وادعونا إليه ودي أفاننا ودي أفاننا وقروه من بيننا
+
+99
+00:12:54,740 --> 00:13:06,660
+وقروه من .. وقروه من بيننا وبينك حجاب فاعمل إننا
+
+100
+00:13:06,660 --> 00:13:08,340
+عاملون
+
+101
+00:13:11,330 --> 00:13:15,510
+برضه غني حركتين عنهم يا إمام؟
+
+102
+00:13:44,750 --> 00:13:55,280
+لا يقتونالذين لا يؤتون الزكاة وهم بالاخيرات .. وهم
+
+103
+00:13:55,280 --> 00:13:59,820
+بالاخيرات .. إيش الحكم ها؟ اقلام .. لا مش اقلام
+
+104
+00:13:59,820 --> 00:14:02,400
+فأشة فوى .. فأشة فوى .. فأشة فوى .. فأشة فوى ..
+
+105
+00:14:02,400 --> 00:14:03,660
+فأشة فوى .. فأشة فوى .. فأشة فوى .. فأشة فوى ..
+
+106
+00:14:03,660 --> 00:14:08,860
+فأشة فوى .. فأشة فوى .. فأشة فوى .. فأشة فوى ..
+
+107
+00:14:08,860 --> 00:14:13,080
+فأشة فوى .. فأشة فوى .. فأشة فوى .. فأشة فوى ..
+
+108
+00:14:13,080 --> 00:14:14,120
+فأشة فوى .. فأشة فوى .. فأشة فوى .. فأشة فوى ..
+
+109
+00:14:14,120 --> 00:14:15,900
+فأشة فوى .. فأشة فوى .. فأ
+
+110
+00:14:26,640 --> 00:14:33,660
+قل اكسر الهمزة التانية كويس، قل أإنكم
+
+111
+00:14:33,660 --> 00:14:39,140
+مد
+
+112
+00:14:39,140 --> 00:14:43,410
+الصلاة، جدش من مد الصلاة الكبرى يا صابرين؟وتجعلون
+
+113
+00:14:43,410 --> 00:14:51,590
+له أندادة .. twice .. وتجعلون له أندادة .. تلالي
+
+114
+00:14:51,590 --> 00:14:57,710
+كرب العالمين و جعل فيها رواسها من فوقها و برك فيها
+
+115
+00:14:57,710 --> 00:15:04,630
+و قدر فيها أقوتها في أربع أيام سوال
+
+116
+00:15:06,680 --> 00:15:11,920
+بس ماتجافيش شوية علامة زي الغناء لأ في أربعة أيام
+
+117
+00:15:11,920 --> 00:15:21,920
+سواء للسائلين في أربعة أيام سواء للسائلين لأ سواء
+
+118
+00:15:21,920 --> 00:15:29,100
+ال .. ده غلط، ناشن الجافة عليها سواء للسائلين سواء
+
+119
+00:15:29,100 --> 00:15:33,920
+للسائلين طب ليش بتلمد؟ سواء .. أيه؟
+
+120
+00:15:46,940 --> 00:15:54,220
+سواء السائلين .. سواء السائلين .. ثم سواء السائلين
+
+121
+00:15:54,220 --> 00:15:55,700
+.. دي بالغناء علمين حركتين
+
+122
+00:16:00,510 --> 00:16:05,610
+وهي ده ما قلنا لها فهو و هي تكسر و ليست ساكنة وان
+
+123
+00:16:05,610 --> 00:16:11,770
+ده الإمام حفظ و هي دخان و هي دخان فقال لها و للأرض
+
+124
+00:16:11,770 --> 00:16:19,610
+اتيا طوعا طوعا او كرها قالت أتينا طائعين الله يفتح
+
+125
+00:16:19,610 --> 00:16:23,890
+عليه يالا
+
+126
+00:16:23,890 --> 00:16:30,780
+يا إيمان اقرأأعوذ بالله من الشباب الرجيم بسم الله
+
+127
+00:16:30,780 --> 00:16:37,180
+الرحمن الرحيم قفضه من سبع .. قفضه من سبع سموات ..
+
+128
+00:16:37,180 --> 00:16:42,740
+قفضه من سبع سموات في يومين وروحا في كل سماء أمرها
+
+129
+00:16:42,740 --> 00:16:50,260
+.. في كل سماء أمرها و أوحى في كل سماء أمرها و زيّن
+
+130
+00:16:50,260 --> 00:16:54,180
+السماء .. قفضه من سماء .. قفضه من سماء .. قفضه من
+
+131
+00:17:03,450 --> 00:17:11,430
+فقول في أنها حكم، أيوة، إيش ال .. إيش الحكم؟ أيوة،
+
+132
+00:17:11,430 --> 00:17:17,970
+فمقدروا حركته، سائقة كان مثل
+
+133
+00:17:43,060 --> 00:17:50,340
+بما أرسلتم بيه فإن
+
+134
+00:17:50,340 --> 00:17:52,000
+بما أرسلتم بيه
+
+135
+00:17:59,830 --> 00:18:04,870
+فأنا عادوا فاستكبروا في الأرض جبال الحق وقالوا من
+
+136
+00:18:04,870 --> 00:18:11,910
+أشد مننا قوة .. لأ عندي الوقف، قوة، بصير أننا همس
+
+137
+00:18:11,910 --> 00:18:17,250
+في الهاق، مش قوة، قوة، نسكن الحرف، اه
+
+138
+00:18:24,800 --> 00:18:31,640
+وأشدت منهم قوة الله
+
+139
+00:18:31,640 --> 00:18:39,670
+يفتح عليك قرأ اسرعبسم الله الرحمن الرحيم فأرسلنا
+
+140
+00:18:39,670 --> 00:18:46,530
+عليهم ريحا سرسرا في
+
+141
+00:18:46,530 --> 00:18:57,190
+أيام نحسات لينذيقهم عذاب القذي في حياة الدنيا ولا
+
+142
+00:18:57,190 --> 00:19:07,020
+عذاب الآخرة أخذاوهم لا ينصرون وأما ثمود فهديناهم
+
+143
+00:19:07,020 --> 00:19:11,580
+فاستحبوا العم .. فاستحبوا .. فاستحبوا العم على ..
+
+144
+00:19:11,580 --> 00:19:18,580
+فاستحبوا العم على الهدى .. على الهدى فأخذتهم صارقة
+
+145
+00:19:18,580 --> 00:19:25,730
+العذاب الهوني .. الهوني بمادة العذاب الهونيالعذاب
+
+146
+00:19:25,730 --> 00:19:32,970
+الهون بما كانوا يكسبون ونجينا الذين آمنوا وكانوا
+
+147
+00:19:32,970 --> 00:19:37,510
+يتقون آمنوا .. يعني حرف المد .. جيبي حركتين ..
+
+148
+00:19:37,510 --> 00:19:42,090
+ياديش بندن مد حروف المد يا إسراء؟ حروف المد .. كام
+
+149
+00:19:42,090 --> 00:19:45,350
+بندن؟ مد حركتين .. أه حركتين .. مد أصلي أو طبيعي
+
+150
+00:19:45,350 --> 00:19:48,990
+يمد مقدار حركتين .. يلا عيد الآية .. ونجينا الذين
+
+151
+00:19:48,990 --> 00:19:57,570
+..لأ اكثر اكتر من حرفتين احسنت
+
+152
+00:20:23,410 --> 00:20:33,590
+وجلودهم بما كانوا يعملون وقالوا
+
+153
+00:20:33,590 --> 00:20:36,270
+لجلودهم
+
+154
+00:20:37,240 --> 00:20:45,460
+وقالوا لجلودهم لم .. لم شاهدتم علينا قالوا أنطقنا
+
+155
+00:20:45,460 --> 00:20:54,300
+اللذي .. أنطقنا الله الذي أنطق كل شيء .. كل .. كل
+
+156
+00:20:54,300 --> 00:21:01,340
+شيء و هو خلقكم .. و هو .. و هو خلقكم أول مرة و
+
+157
+00:21:01,340 --> 00:21:04,280
+إليه ترجعون بيفتحوا
+
+158
+00:21:15,160 --> 00:21:26,620
+بدي أرد على
+
+159
+00:21:26,620 --> 00:21:31,740
+الجوال يا أستاذ، أه؟ الدكتور، رئيس القسم السلام
+
+160
+00:21:31,740 --> 00:21:40,790
+عليكمالسلام عليكم .. عليكم السلام .. بسم الله ..
+
+161
+00:21:40,790 --> 00:21:42,050
+أيوة معاك يا وستاني
+
+162
+00:21:51,910 --> 00:21:55,450
+عارفين يقولوا أنك عارفينها؟ لأ أخصوش عليهم أنا بس
+
+163
+00:21:55,450 --> 00:21:58,230
+بحذرهم مايتأخروش أكتر من المعودة لحد اليومية يعنى
+
+164
+00:21:58,230 --> 00:22:02,810
+و أنا في بعض اللي بيجي وزمانيها أدرس في أديانة؟ لأ
+
+165
+00:22:02,810 --> 00:22:06,550
+أصلا والله كتير بيجي اليوم عشرين طالب أجلوا أجلتهم
+
+166
+00:22:06,550 --> 00:22:10,190
+يومين تلاتة بس مايزلوش أزيادة عن اللزوم عشان
+
+167
+00:22:10,190 --> 00:22:12,670
+مايصيرش ضغط على باجي الطالبات يعني اللي في
+
+168
+00:22:12,670 --> 00:22:17,350
+مواعيدهم هدولة أول في ميسا قدرتوا مجرد قدر منهم؟
+
+169
+00:22:17,350 --> 00:22:22,190
+مافيش حدر؟ماشا، بس أنت الله يبارك فيك، يعني نبّههم
+
+170
+00:22:22,190 --> 00:22:26,610
+اللي هم ييجوا في مواعيدهم ما شاء الله، يعطيكي
+
+171
+00:22:26,610 --> 00:22:31,310
+العافية، سلامة
+
+172
+00:22:31,310 --> 00:22:39,050
+ماللي
+
+173
+00:22:39,050 --> 00:22:43,610
+كنت تقرأ؟ يعني ماعرفش اسمك، ذكريني يعني، يلا يا
+
+174
+00:22:43,610 --> 00:22:43,930
+شيرين
+
+175
+00:22:51,310 --> 00:22:56,690
+أي يشهد .. يشهد
+
+176
+00:22:56,690 --> 00:23:07,090
+عليكم سماعكم ولا جلودكم
+
+177
+00:23:07,090 --> 00:23:12,190
+وعنانتم،
+
+178
+00:23:12,190 --> 00:23:13,550
+لا يخفأ يا شيرين
+
+179
+00:23:21,350 --> 00:23:35,590
+أرجع و أصلي لآية و لكن ظننتم ميمة
+
+180
+00:23:35,590 --> 00:23:42,970
+جامعة مضمونة و ذلكم غنكم اللذي غنكم
+
+181
+00:23:59,130 --> 00:24:05,870
+وذلكم ضنكم الذي ضننتم بربكم
+
+182
+00:24:16,680 --> 00:24:20,560
+أرضاكم فأصبحتم من الخاسرين خزيب يتغامل مين مع
+
+183
+00:24:20,560 --> 00:24:29,960
+المين؟ أصبحتم من الخاسرين من الخ .. الخاسرين
+
+184
+00:24:29,960 --> 00:24:35,740
+فأصبحتم من الخاسرين .. من الخاسرين مش الخ .. الخ
+
+185
+00:24:35,740 --> 00:24:38,100
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+186
+00:24:38,100 --> 00:24:38,560
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+187
+00:24:38,560 --> 00:24:41,100
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+188
+00:24:41,100 --> 00:24:41,640
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+189
+00:24:41,640 --> 00:24:42,700
+.. خاسرين .. خاسرين .. خاسرين .. خاسرين .. خاسرين
+
+190
+00:24:42,700 --> 00:24:49,570
+.. خاسرين ..عشان إيش؟ قبلها، مش بعدها، قبلها حرف
+
+191
+00:24:49,570 --> 00:24:53,290
+من حروف الصداق تنقض، حروف التخيم والاستعلاء، بنقول
+
+192
+00:24:53,290 --> 00:24:59,990
+.. مش بقولش الخاسرين، الخ .. غلط، الخاسرين، كامل
+
+193
+00:24:59,990 --> 00:25:02,930
+وإي يستعتبوا
+
+194
+00:25:13,940 --> 00:25:17,440
+من المعتبين بس ارجع واسيبي برضه اتغمل من معلمين
+
+195
+00:25:17,440 --> 00:25:24,840
+حركتين فما هم من المعتبين فما هم من المعتبين و
+
+196
+00:25:24,840 --> 00:25:31,420
+قضينا لهم قرناء و قيدنا لهم قرناء لأ فخمة ضاب و
+
+197
+00:25:31,420 --> 00:25:40,120
+قيدنا لهم قرناء و قيدنا ضاب و قيدنا لهم قرناء و
+
+198
+00:25:40,120 --> 00:25:41,820
+فزينا لهم قرناء
+
+199
+00:25:44,850 --> 00:25:51,970
+الهمز مفتوحة يعني قرنا أفزينوا وقيدنا لهم قرنا
+
+200
+00:25:51,970 --> 00:25:58,930
+أفزينوا لهم ما بين .. لهم .. لهم ما .. لهم ما بين
+
+201
+00:25:58,930 --> 00:26:04,390
+أيديهم وما خلف .. وما خلفهم وحق عليهم .. وحق عليهم
+
+202
+00:26:04,390 --> 00:26:08,070
+عليهم القور من .. القور من .. اكسر الحق كويس قبل
+
+203
+00:26:08,070 --> 00:26:14,350
+الميم عليهموا عليهم القور في أمهمجيبي الماد
+
+204
+00:26:14,350 --> 00:26:22,170
+ياشيرين، إيش هالنوع الماد؟ ماد جائز وانفصل، جداش
+
+205
+00:26:22,170 --> 00:26:27,610
+مقدار ياشيرين الماد جايز وانفصل؟ أربع أو خمس
+
+206
+00:26:27,610 --> 00:26:31,510
+حركات، طب يالا جيبي، يا أربع يا خمس حركات وحفظ
+
+207
+00:26:31,510 --> 00:26:37,690
+عليهم القول في .. عليهم .. عليهم القول .. عليهم
+
+208
+00:26:37,690 --> 00:26:44,590
+القول في أمم .. في أمم قد خلت من قبلهم ..من قبلهم
+
+209
+00:26:44,590 --> 00:26:55,510
+.. من الجن والإنس
+
+210
+00:26:55,510 --> 00:27:02,030
+وقيدنا
+
+211
+00:27:02,030 --> 00:27:08,430
+لهم قرن أفذين لهم ما بين أيديهم .. ما بين أيديهم
+
+212
+00:27:08,430 --> 00:27:14,420
+وما خلفهم .. وما خلفهموحق عليهم القول .. وحق عليهم
+
+213
+00:27:14,420 --> 00:27:18,140
+القول في .. برضه ضمن مين؟ عليهم القول .. عليهم
+
+214
+00:27:18,140 --> 00:27:27,360
+القول في أمم قد خلت من قرضهم، قد خلت من قبلهم من
+
+215
+00:27:27,360 --> 00:27:34,930
+الجن والأنإنهم كانوا خاسرين، خاسرين،
+
+216
+00:27:34,930 --> 00:27:40,430
+خاسرين،
+
+217
+00:27:40,430 --> 00:27:45,650
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+218
+00:27:45,650 --> 00:27:45,690
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+219
+00:27:45,690 --> 00:27:45,990
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+220
+00:27:45,990 --> 00:27:46,750
+خاسرين، خاسرين، خاسرين، خاسرين، خاسرين، خاسرين،
+
+221
+00:27:46,750 --> 00:27:52,250
+خاسرين، خاسرين، خاسرين،
+
+222
+00:27:52,250 --> 00:27:53,650
+خاسرين، خاسرين
+
+223
+00:27:59,550 --> 00:28:15,450
+ولا .. ولا نجذيانهم أديها يا نهار قلني
+
+224
+00:28:15,450 --> 00:28:19,470
+عنهم يا نهار أعداء الله النار
+
+225
+00:28:22,400 --> 00:28:29,380
+مد .. مد المد المتصل جزاء .. جزاء .. جزاء أعداء
+
+226
+00:28:29,380 --> 00:28:36,520
+الله ناولهم فيها دارهم .. دارهم خد جزاء بما كان ..
+
+227
+00:28:36,520 --> 00:28:44,260
+جزاء بما كانوا بأياتنا يشهدوا وقال الذين كفروا
+
+228
+00:28:44,260 --> 00:28:50,480
+ربنا أرينا الذين .. الذين .. أرينا الذين .. الذين
+
+229
+00:28:50,480 --> 00:28:50,900
+.. الذين .. الذين .. الذين .. الذين .. الذين ..
+
+230
+00:28:53,440 --> 00:28:59,240
+الذين أبضانا من
+
+231
+00:28:59,240 --> 00:29:11,340
+الجن والإنس والإنسي والإنسي
+
+232
+00:29:11,340 --> 00:29:17,360
+والإنسي
+
+233
+00:29:17,360 --> 00:29:17,380
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+234
+00:29:17,380 --> 00:29:17,480
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+235
+00:29:17,480 --> 00:29:19,620
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+236
+00:29:19,620 --> 00:29:20,500
+والإنسي والإنسي والإنسي والإنسي والإنسي والإنسي
+
+237
+00:29:20,500 --> 00:29:25,460
+والإنسي والإنسيوالإنس نجعلهم تحت أقدامنا ليكون من
+
+238
+00:29:25,460 --> 00:29:32,600
+الأسفلين إن الذين قالوا ربنا الله ثم استقاموا ثم
+
+239
+00:29:32,600 --> 00:29:38,860
+استقاموا ثم استقاموا وتتنثروا عليهم ولا إجتوا ولا
+
+240
+00:29:38,860 --> 00:29:44,920
+تفافوا ألا تفافوا ولا تحزنوا وأبشروا بالجنة اللي
+
+241
+00:29:44,920 --> 00:29:48,400
+كنتوا وابشروا بالجنة
+
+242
+00:29:52,680 --> 00:29:59,440
+التي .. اللتي كنتم .. كنتم توعدون .. الله يفتح
+
+243
+00:29:59,440 --> 00:30:06,200
+عليك .. الله يفتح عليك، تقراي هناأعوذ بالله من
+
+244
+00:30:06,200 --> 00:30:15,100
+الشيطان الرجيم بسم الله الرحمن الرحيم نحن أولياءكم
+
+245
+00:30:15,100 --> 00:30:21,860
+في الحياة الدنيا وفي الآخرة ولكم فيها ما تشتهي
+
+246
+00:30:21,860 --> 00:30:33,000
+أنفسكم ولكم فيها ما تدعوننزلا من غفور .. من غفور
+
+247
+00:30:33,000 --> 00:30:39,060
+الرحيم ايوه؟ ايش الحكم أنه غفور الرحيم؟ اتغام بدون
+
+248
+00:30:39,060 --> 00:30:43,990
+غنة ايوه اتغام بدون غنة، ليه؟حرف .. نون مع الرأس
+
+249
+00:30:43,990 --> 00:30:47,730
+.. ايوة ده مافي أنا حرف الرأس .. يلا يلا ومن أحسن
+
+250
+00:30:47,730 --> 00:30:58,170
+قولا ممن دعا إلى الله وعمل صالحا وعمل صالحا وقال
+
+251
+00:30:58,170 --> 00:31:06,930
+إنني من المسلمين ولا تستوي الحسنة ولا السيئةادفع
+
+252
+00:31:06,930 --> 00:31:14,030
+بالتي هي أحسن فإذا الذي بينك وبينه عداوة فإذا الذي
+
+253
+00:31:14,030 --> 00:31:25,510
+بينك وبينه عداوة عداوة كأنه ولي حميموما يلقها إلا
+
+254
+00:31:25,510 --> 00:31:33,310
+الذين صبروا وما
+
+255
+00:31:33,310 --> 00:31:44,830
+يلقها إلا ذو حظ عظيم وإما ينزغنك من الشيطان نزغ
+
+256
+00:31:44,830 --> 00:31:53,890
+فاستعِذ باللهفاستعِذ بالله إنه هو السميع العليم
+
+257
+00:31:53,890 --> 00:32:02,010
+الله يفتح عليك تكملي يا حنة ومن
+
+258
+00:32:02,010 --> 00:32:07,630
+آيات الليلة الليل والنهار والشمس والقمر لا تسجدوا
+
+259
+00:32:07,630 --> 00:32:13,490
+للشمس ولا للأرض لا وابحثي اللي لا تسجدوا لا تسجدوا
+
+260
+00:32:13,490 --> 00:32:21,270
+للشمس ولا للأرضخلقهم إن كنتوا أيام تعملوا تفضلي
+
+261
+00:32:21,270 --> 00:32:26,410
+بالاخفاء الأول يا حنان إن كنتوا أيام تعملوا وإن
+
+262
+00:32:26,410 --> 00:32:31,790
+استثمروا فالذين عندهم عين لربك يسبحون له الليل
+
+263
+00:32:31,790 --> 00:32:41,650
+والنهار وهم لا يسألونه ومن آياته أنك
+
+264
+00:32:41,650 --> 00:32:42,890
+ترى القعدة خاشة
+
+265
+00:32:45,880 --> 00:32:56,220
+قاشعة فإذا .. قاشعة فإذا أنزلنا عليها الماء تزدد
+
+266
+00:32:56,220 --> 00:33:05,560
+وربت إن الذي يحيى على محي الموتى إنه على كل شيء ..
+
+267
+00:33:05,560 --> 00:33:12,040
+على كل شيء خدير إن الذين يحيون فيه
+
+268
+00:33:23,870 --> 00:33:29,550
+أما .. أما
+
+269
+00:33:29,550 --> 00:33:32,370
+يأتي آمنا
+
+270
+00:33:37,810 --> 00:33:50,890
+برضه عندنا الإضغام التاني اما يأتي اميني
+
+271
+00:33:50,890 --> 00:33:57,870
+يوم القيامة اعملوا .. اعملوا ما شئتم إنه بما
+
+272
+00:33:57,870 --> 00:33:58,730
+تعملونه
+
+273
+00:34:06,240 --> 00:34:12,400
+وإنه لكتاب عزيزي لا يأتيه الباطل .. لا يأتيه
+
+274
+00:34:12,400 --> 00:34:22,080
+الباطل من بين يديه ولا من خلفه ولا من خلفه اظهر،
+
+275
+00:34:22,080 --> 00:34:27,560
+يعني النور مع الخأ من حروف الاضهر، صح؟ ولا من ..
+
+276
+00:34:27,560 --> 00:34:34,960
+ولا من خلفه لا زيل من حكيهبرضه نفس الاشي يا حنان،
+
+277
+00:34:34,960 --> 00:34:43,400
+من حكي؟ من .. من حروف إيش؟ إيش حروف الظهار؟ الله
+
+278
+00:34:43,400 --> 00:34:48,600
+يفتح عليك دي هي الآية، لا يأتيه الباطللا يأتيه
+
+279
+00:34:48,600 --> 00:34:53,880
+الباطل .. لا يأتيه الباطل من بين يديه ولا من خلفه
+
+280
+00:34:53,880 --> 00:35:00,420
+تم .. ولا من خلفه تمثيل من حكيم حميد ما يقاربلك
+
+281
+00:35:00,420 --> 00:35:06,360
+إلا .. ما يقاربلك إلا ما قد قيل للرسول من قبلك إن
+
+282
+00:35:06,360 --> 00:35:12,920
+ربك لده مغفرتك وده عقاب أمين مافتح عليه؟
+
+283
+00:35:20,220 --> 00:35:26,640
+و ده القلب و
+
+284
+00:35:26,640 --> 00:35:41,140
+هو
+
+285
+00:35:41,140 --> 00:35:47,160
+و
+
+286
+00:35:47,160 --> 00:35:56,240
+هو عليهم عناوالدنيا لا يوميون في أذانهم وخمومة
+
+287
+00:35:56,240 --> 00:36:01,820
+وعلى دماغها دائما في و هو و هي بنضم الهاء إذا كانت
+
+288
+00:36:01,820 --> 00:36:05,220
+مضمومة و بنكسرها إذا كانت مكسورة، بنخليهاش ساكنة
+
+289
+00:36:05,220 --> 00:36:12,690
+بالمرة، لأن سكون الهاء لحن جالي، ليش طيب؟لأن رواية
+
+290
+00:36:12,690 --> 00:36:16,510
+حفص فناصم بيضم لها، في عندنا رواية إمام الشعبة
+
+291
+00:36:16,510 --> 00:36:20,750
+بيسكن لها، بيقول و هو .. و هو عشان هيك لازم احنا
+
+292
+00:36:20,750 --> 00:36:25,850
+نضمها و نوضح .. ضمها عشان نبين قراءة حفص، يالا و
+
+293
+00:36:25,850 --> 00:36:30,650
+هو عليهم أنا ..
+
+294
+00:36:30,650 --> 00:36:34,970
+بعيد
+
+295
+00:36:34,970 --> 00:36:37,710
+.. ماسمعتش الدال بالمرة ياه ده، بعيد
+
+296
+00:36:42,200 --> 00:36:54,200
+بعيدة .. بعيدة
+
+297
+00:36:54,200 --> 00:36:58,760
+سبقت
+
+298
+00:36:58,760 --> 00:36:59,680
+من ربك
+
+299
+00:37:03,310 --> 00:37:21,870
+هذه الآية و لقد آتينا نفس
+
+300
+00:37:21,870 --> 00:37:28,790
+الاشي برضه مريب البقىالباق والدال من حروف إيش؟ طيب
+
+301
+00:37:28,790 --> 00:37:31,870
+من القلقة ليه المخرج؟ أول حرف من حروف القلقة لو
+
+302
+00:37:31,870 --> 00:37:36,430
+موقوف عليه إيش بيكون علناه؟قال قلقه كبرى، طيب يا
+
+303
+00:37:36,430 --> 00:37:44,490
+.. وإنهم لفي شك إنه منكم غريب من عمل بارحانة لنفسه
+
+304
+00:37:44,490 --> 00:37:53,210
+ومن أساقف عليها وما ربك بيضل بالعجيب ليه اترل
+
+305
+00:37:53,210 --> 00:38:00,230
+الساعة وما تخرج من ثمرات من أكنامها وما تحملوا من
+
+306
+00:38:00,230 --> 00:38:01,070
+كنت
+
+307
+00:38:18,750 --> 00:38:20,690
+الله يفتحهم.
+
+308
+00:38:23,330 --> 00:38:30,210
+بسم الله الرحمن الرحيم وضعنا عنهم ما كانوا يبقوا
+
+309
+00:38:50,210 --> 00:38:58,530
+خوني عنه ولا إذا دقناه رحمة منا لمنا
+
+310
+00:39:04,100 --> 00:39:12,980
+من بعد ضراء مسته من بعد ضراء على همزة فاتحة ضراء
+
+311
+00:39:12,980 --> 00:39:21,540
+مسته من بعد ضراء .. من بعد ضراء مسته ليقول أنها
+
+312
+00:39:21,540 --> 00:39:31,460
+ذالي وما أظن الساعة وما أظن الساعة قائمة أول أرجعت
+
+313
+00:39:31,460 --> 00:39:32,420
+إلى ربي
+
+314
+00:39:50,950 --> 00:39:56,090
+فننبأن .. فننبأن
+
+315
+00:39:56,090 --> 00:40:03,090
+.. فننبأن .. فننب .. فننب .. فننب .. فننب .. فننب
+
+316
+00:40:03,090 --> 00:40:03,410
+.. فننب .. فننب .. فننب .. فننب .. فننب .. فننب ..
+
+317
+00:40:03,410 --> 00:40:15,210
+فننب ..فلننبي أن .. كيف؟
+
+318
+00:40:15,210 --> 00:40:21,210
+فلننبي أن .. أحسنت،
+
+319
+00:40:21,210 --> 00:40:29,690
+كويس، حسنا يالله
+
+320
+00:40:29,690 --> 00:40:30,670
+يا يسرى
+
+321
+00:40:33,960 --> 00:40:40,020
+فلنبقى أن الذين تفروا بما عملوا و لنضيق أنهم من ..
+
+322
+00:40:40,020 --> 00:40:48,540
+و لنضيق أنهم من عذاب غليظ و إذا أنعمنا على إنسان
+
+323
+00:40:48,540 --> 00:40:55,180
+أعرض و نقى بجانبه و إذا مسه الشر و إذا مسه الشر
+
+324
+00:40:55,180 --> 00:41:07,850
+فده دعاء عريض عريض قل أرايتم أنجفش عنهم قل قرأيتم
+
+325
+00:41:07,850 --> 00:41:15,830
+إن كان من عيد الجنان من عيد الله من عيد الله ثم
+
+326
+00:41:15,830 --> 00:41:23,370
+كفرتم
+
+327
+00:41:23,370 --> 00:41:31,810
+به من أضلوا من أضلوا من من هو فيه
+
+328
+00:41:36,380 --> 00:41:47,100
+جيبت ده ليه كويس يا عزيزي؟ بعيد سنريهم
+
+329
+00:41:47,100 --> 00:41:55,780
+.. سنريهم آيات .. آياتنا في الآفاق وفي أنفسهم حتى
+
+330
+00:41:55,780 --> 00:42:03,360
+.. في أنفسهم حتى تبين لهم .. يتبين لهم .. يتبين
+
+331
+00:42:04,970 --> 00:42:13,470
+وفي أنفسهم حتى يتبين لهم أنه الحق أولم يكفي برب
+
+332
+00:42:13,470 --> 00:42:23,210
+كأنه على كل شيء شهيد ألا إنهم في مرية .. مرية في
+
+333
+00:42:23,210 --> 00:42:30,300
+مريت يعني إيش حكم الرأهان؟سبقات بيكسر؟ مكسورة؟ لأ
+
+334
+00:42:30,300 --> 00:42:35,040
+هي مش مكسورة، هي ساكنة سبقات كسر
+
+335
+00:42:37,350 --> 00:42:44,350
+مش ضرورة ممكن تحضر بغي كده جالي الدكتور زاده .. هو
+
+336
+00:42:44,350 --> 00:42:50,430
+عطل بيجي ..معلش ..معلش ..مش
+
+337
+00:42:50,430 --> 00:42:55,350
+مش كده ..العادة ..العادة نرتاح و ندرس اللي جابتنا
+
+338
+00:42:55,350 --> 00:42:59,190
+..انا مش نرتاح ..الله يطلع ..و الله هي ترمت حرام
+
+339
+00:42:59,190 --> 00:42:59,210
+..
+
+340
+00:43:05,060 --> 00:43:12,040
+أنا عارفين كمان .. خلاص طيب انا بصدق وانتوا ..
+
+341
+00:43:12,040 --> 00:43:23,540
+معلش هتذكر يا أستاذ الجهاز؟ في مرية
+
+342
+00:43:26,830 --> 00:43:36,550
+هو في نوية .. في ملية من لقاء ربهم في نوية من لقاء
+
+343
+00:43:36,550 --> 00:43:46,650
+ربهم ألا إنه بكل شيء محيط .. محيط .. اقع .. محيط
+
+344
+00:43:46,650 --> 00:43:52,890
+.. هو في الطائرة يعني .. محيط .. محيط .. الله يفتح
+
+345
+00:43:52,890 --> 00:43:53,130
+عنا
+
+346
+00:43:57,930 --> 00:44:04,890
+أعوذ بالله من الشيخان الرجيم بسم الله الرحمن
+
+347
+00:44:04,890 --> 00:44:09,470
+الرحيم حاميم
+
+348
+00:44:09,470 --> 00:44:15,890
+.. لأ ح .. من حوف .. حيون طهر .. لازم ده .. حركتين
+
+349
+00:44:15,890 --> 00:44:23,980
+.. تكتب حرف واحد لكن تمد مقدار حركتين حاميم ..ميم
+
+350
+00:44:23,980 --> 00:44:33,240
+جدش مادناها وسط حركات ماعرفش ready هي يعني حميم
+
+351
+00:44:33,240 --> 00:44:41,020
+تنزل الكتاب من الله العزيزي العليم غافر الذنب
+
+352
+00:44:41,020 --> 00:44:54,830
+وقابل التوبةغافر الذنب
+
+353
+00:44:54,830 --> 00:45:02,310
+و قابل التوب شديد العقاب ذي الطول ذي الطول لا إله
+
+354
+00:45:02,310 --> 00:45:11,560
+إلا هو إليه المصيرما يجادل في آيات الله إلا الذين
+
+355
+00:45:11,560 --> 00:45:20,220
+كفروا، إلا الذين كفروا، فلا يغررك تقلبهم في البلاد
+
+356
+00:45:20,740 --> 00:45:28,260
+كذبت قبلهم قوم نوح .. كذبت قبلهم قوم نوح و الأحزاب
+
+357
+00:45:28,260 --> 00:45:36,020
+.. و الأحزاب من بعدهم و همت كل أمة .. و همت .. و
+
+358
+00:45:36,020 --> 00:45:44,620
+همت كل أمتهم برسولهم ليأخذوهو جادلوا بالباطل
+
+359
+00:45:44,620 --> 00:45:55,020
+ليضحضوا
+
+360
+00:45:55,020 --> 00:46:03,240
+به الحق فأخذتهم فكيف كان عقابك؟ وكذلك حقت كلمة ربك
+
+361
+00:46:03,240 --> 00:46:12,590
+على الذين كفروا أنهم أصحاب النارالذين يحملون العرش
+
+362
+00:46:12,590 --> 00:46:19,710
+ومن حوله يسبحون
+
+363
+00:46:19,710 --> 00:46:28,100
+بحمد ربهميسبحون بحمد ربهم و يؤمنون به و يستغفرون
+
+364
+00:46:28,100 --> 00:46:35,820
+للذين آمنوا ربنا و سعت كل شيء .. و سعت كل شيء .. و
+
+365
+00:46:35,820 --> 00:46:41,220
+سعت كل شيء رحمته .. لأ ما تعملش غناء .. شيء رحمته
+
+366
+00:46:41,220 --> 00:46:48,790
+و علمه .. كل شيء رحمته و علمهفاخفر للذين تابوا
+
+367
+00:46:48,790 --> 00:46:55,710
+فاخفر .. فاخفر للذين ساكنة ساكنة .. ساكنة لكن ايه؟
+
+368
+00:46:55,710 --> 00:47:00,750
+مسبوقة؟ بتكسر؟ فاخفر للذين تابوا واتبعوا سبيلك
+
+369
+00:47:00,750 --> 00:47:04,890
+واطهم عذابهم واتبعوا سبيلك واتبعوا سبيلك .. في
+
+370
+00:47:04,890 --> 00:47:08,810
+الناس حروف المد نخطفها خطف و نضيع الحركتين واتبعوا
+
+371
+00:47:08,810 --> 00:47:16,020
+.. الواو .. واتبعوا سبيلكواتبعوا سبيلك واطهم عذاب
+
+372
+00:47:16,020 --> 00:47:27,760
+الجحيم ربنا وأدخلهم جنات عدنن التي وعدتهم ومنصا
+
+373
+00:47:27,760 --> 00:47:38,160
+ومن صلح من آبائهم وأزواجهم وذرياتهم إنك أنت العزيز
+
+374
+00:47:38,160 --> 00:47:44,300
+الحكيم الله يفتح عناأقرأ يعني بسم الله الرحمن
+
+375
+00:47:44,300 --> 00:47:52,500
+الرحيم وقيم السيئات ومن تق السيئات يومين فقد رحمته
+
+376
+00:47:52,500 --> 00:48:01,020
+فقد رحمته فقد رحمته وذلك هو الفوز العظيم إن الذين
+
+377
+00:48:01,020 --> 00:48:07,440
+كفروا نادونا .. نادونا .. إن الذين كفروا نادونا
+
+378
+00:48:07,440 --> 00:48:12,830
+مفهو الله أفضللما اطلع يأكبر مني مقتكم .. مني
+
+379
+00:48:12,830 --> 00:48:19,130
+مقتكم او نفسكم اتدعون
+
+380
+00:48:19,130 --> 00:48:24,590
+الى الايمان فتكفرونأنتوا ادعونا إلى الإيمان
+
+381
+00:48:24,590 --> 00:48:31,270
+بتكفرون قالوا ربنا أمانتنا اتنتين واحنايتنا
+
+382
+00:48:31,270 --> 00:48:38,070
+واحنايتنا اتنتين فاطرفنا ببنوقنا تاني أخرج من
+
+383
+00:48:38,070 --> 00:48:42,290
+السبيل ذلك بأنه
+
+384
+00:48:48,750 --> 00:48:56,930
+ذلكم بأنه إذا دعي الله .. إذا دعي الله وحده كفرتم
+
+385
+00:48:56,930 --> 00:49:02,910
+وإي يشرق به تؤمنوا .. كف ساكنة وإي يشرق به تؤمنوا
+
+386
+00:49:02,910 --> 00:49:08,630
+.. وإي يشرق به ت .. وإي يشرق به تؤمنوا فالحكم إلا
+
+387
+00:49:08,630 --> 00:49:16,140
+العلي الكبير .. الكبير .. العلي الكبيرهو الذي
+
+388
+00:49:16,140 --> 00:49:23,520
+يريكم آياته .. هو الذي يريكم آياته وينزل لكم ..
+
+389
+00:49:23,520 --> 00:49:28,180
+وينزل .. وينزل لكم .. وينزل .. وينزل لكم .. وينزل
+
+390
+00:49:28,180 --> 00:49:33,860
+لكم .. وينزل لكم .. وينزل لكم من السماء لسقى وما
+
+391
+00:49:33,860 --> 00:49:40,200
+يتذكر منا مينين وانا بتغامي ايمان الا مينين وما
+
+392
+00:49:40,200 --> 00:49:47,060
+يتذكر منا مينينفادعو الله مخلصين لو ابتدوا ولو كره
+
+393
+00:49:47,060 --> 00:49:54,820
+الكافرون رفيع الدرجة تدلعش يلقى الروح منه يلقى
+
+394
+00:49:54,820 --> 00:49:59,940
+الروح من أمره على .. يلقى الروح من أمره على من
+
+395
+00:49:59,940 --> 00:50:05,060
+يشاء على من يشاء
+
+396
+00:50:05,060 --> 00:50:12,430
+من عباده ليوضع يوم التلاعبيوم هم بارزونا .. يوم هم
+
+397
+00:50:12,430 --> 00:50:21,110
+بارزونا .. يوم هم بارزونا .. يوم هم بارزونا .. يوم
+
+398
+00:50:21,110 --> 00:50:25,810
+هم بارزونا .. يوم هم بارزونا .. يوم هم بارزونا ..
+
+399
+00:50:25,810 --> 00:50:32,250
+لا يفع الله منهم شيء .. منهم شيء .. منهم شيء ..
+
+400
+00:50:32,250 --> 00:50:38,650
+لمنهم كل يوم لله .. لمنهم كل يوم لله واحد بقىالله
+
+401
+00:50:38,650 --> 00:50:47,330
+يفتح عليك، يا ناصر بسم الله الرحمن الرحيم اليوم
+
+402
+00:50:47,330 --> 00:50:53,550
+أتجزأ من كل نفسي لأنها كتبت يوم الآزفتي ذي القلوب
+
+403
+00:50:53,550 --> 00:50:56,930
+وأنذرهم
+
+404
+00:50:56,930 --> 00:51:05,890
+يوم الآزفتي يوم الآزفتي ذي القلوب أسرق قرايا
+
+405
+00:51:05,890 --> 00:51:13,290
+الصبرين وأنذرهمالرأس ساكنة سبقت بيكسر، إيش حكمها؟
+
+406
+00:51:13,290 --> 00:51:14,190
+مرقق .. مرققية
+
+407
+00:51:19,890 --> 00:51:41,930
+لدى .. لدى الحنادق يدعونا
+
+408
+00:51:42,920 --> 00:51:47,640
+يبيعونا من ضمنه وإنما لو تجدوا لي لا يقولون شيء
+
+409
+00:51:47,640 --> 00:51:54,480
+إنه هو السميع البصير أو لم يسيروا من الأرض فينظروا
+
+410
+00:51:54,480 --> 00:51:58,400
+كيف كان عقبة الذين كانوا هنا قبلهم
+
+411
+00:52:04,300 --> 00:52:12,860
+كانهم أشد من قوته وأدوى في الأرض فأخذه الله بدونهم
+
+412
+00:52:12,860 --> 00:52:20,000
+فأخذه الله بدونهم فأخذه الله بدونهم وما كان لهم من
+
+413
+00:52:20,000 --> 00:52:28,430
+الطاقم ودانهم .. الله يفتح علي كان لي عارفبسم الله
+
+414
+00:52:28,430 --> 00:52:35,350
+الرحمن الرحيم قرأت يا روانضة؟ yeah .. ذلك بأنهم
+
+415
+00:52:35,350 --> 00:52:40,470
+كانت تزيد رسلهم بالبيناتي فكفروا .. برضه بالفعل
+
+416
+00:52:40,470 --> 00:52:44,270
+شفتوا يا ماريا رسلهم بالبيناتي
+
+417
+00:52:45,660 --> 00:52:53,540
+ذلك بأنه كانت تاتيهم رسلهم بالبينات فجفعوا فأخذهم
+
+418
+00:52:53,540 --> 00:53:08,280
+الله إنه قوي شديد العقاب و لقد أرسلنا موسى بآياتنا
+
+419
+00:53:08,280 --> 00:53:18,600
+وسلطة مبين إلى فرعون و هامالوقارونة .. وقارونة ..
+
+420
+00:53:18,600 --> 00:53:27,720
+إلى فرعون وهامان وقارونة فقالوا ساخر مكذاب فلمّا
+
+421
+00:53:27,720 --> 00:53:35,740
+جاءهم بالحق من عندنا قالوا اقتلوا .. قالوا اقتلوا
+
+422
+00:53:36,000 --> 00:53:51,740
+أبنا الذين آمنوا معه
+
+423
+00:53:51,740 --> 00:54:00,840
+واستحيوا نساءهم وما كيد الكافرين إلا في ضلال وقال
+
+424
+00:54:00,840 --> 00:54:10,540
+فرعون وقال فرعون ذرونيقلت للقاهة اقتل موسى اقتل
+
+425
+00:54:10,540 --> 00:54:21,780
+موسى وليدعو ربه إني أخاف أي يبدل دينكم إني أخاف أي
+
+426
+00:54:21,780 --> 00:54:28,940
+يبدل دينكم أو أي .. أو أي يضغر في الأرض الفساد
+
+427
+00:54:28,940 --> 00:54:35,020
+وقال موسى إني عدت بربي وربكم
+
+428
+00:54:56,660 --> 00:54:59,920
+علي صوتك يعني علي صوتك شويه
+
+429
+00:55:05,570 --> 00:55:09,690
+من آل فرعونة
+
+430
+00:55:09,690 --> 00:55:16,730
+من آل فرعونة يكتموا إيمانه وتقتلونا من آل فرعونة
+
+431
+00:55:16,730 --> 00:55:23,530
+يكتموا إيمانه تقتلونا جيبلي مادة الصلاة الكبرى
+
+432
+00:55:23,530 --> 00:55:25,090
+تقتلونا
+
+433
+00:55:34,250 --> 00:55:42,930
+رجلًا عندك من فترة رجلًا أي يقول رجلًا
+
+434
+00:55:42,930 --> 00:55:49,890
+.. رجلًا .. رجلًا .. رجلًا أي يقول ربي الله ومجا
+
+435
+00:55:49,890 --> 00:55:56,710
+أكم بالبينات جا أكم بالبينات ومجا أكم بالبينات من
+
+436
+00:55:56,710 --> 00:56:03,510
+ربكم وإيه كاببه فعليه كاببه وإيه كاببه فعليه كاببه
+
+437
+00:56:10,150 --> 00:56:24,490
+كذبوه وإي يكون صادق أيصركم بعضه
+
+438
+00:56:24,490 --> 00:56:32,590
+بعض الذي يعيدكم يعيدكم
+
+439
+00:56:33,860 --> 00:56:42,720
+انت الله لا يدي من هو مصرفا كذاب كذاب كذاب يا قومي
+
+440
+00:56:42,720 --> 00:56:47,920
+لكم يوم اليوم ماضيين في الأرض فمن ينصرنا من فأس
+
+441
+00:56:47,920 --> 00:56:57,540
+الأنجان بس اوصل اوصل فمن ينصرنا فمن ينصرنا من فأس
+
+442
+00:56:57,540 --> 00:57:20,470
+الأنجان قالت العوزما أريكم أخافوا
+
+443
+00:57:29,720 --> 00:57:39,700
+مثل .. وما
+
+444
+00:57:39,700 --> 00:57:45,700
+الله يريده
+
+445
+00:57:45,700 --> 00:57:52,680
+الله يفتح حاله .. كان بيا فات .. افادوهبسم الله
+
+446
+00:57:52,680 --> 00:58:01,060
+الرحمن الرحيم ويا قوم إني أخاف عليكم يوم التناد
+
+447
+00:58:01,060 --> 00:58:08,220
+يوم تولون مدبغين مالكم من الله من عاص .. من عاص
+
+448
+00:58:08,220 --> 00:58:16,980
+يوم تولون مدبغين مالكم من الله من عاص ومن يظل الله
+
+449
+00:58:16,980 --> 00:58:19,200
+فما له منهاد
+
+450
+00:58:22,510 --> 00:58:30,170
+ولقد جاءكم يوسف من قبل بالبينات فما زلتم .. فما
+
+451
+00:58:30,170 --> 00:58:41,250
+زلتم في شك مما جاءكم به حتى إذا هلك قلتم ليبعث
+
+452
+00:58:41,250 --> 00:58:48,930
+الله ليبعث الله لأ قلتم .. قلتم عشان تدا .. تدا مش
+
+453
+00:58:48,930 --> 00:58:51,230
+قبيح قلتم ليبعث الله
+
+454
+00:59:09,600 --> 00:59:13,280
+بغير سلطان أتاهم
+
+455
+00:59:17,160 --> 00:59:19,940
+يغير سلطان أتاهم .. مافيش ما أتىهم هم زي القطع أو
+
+456
+00:59:19,940 --> 00:59:27,380
+الكلمة يغير سلطان أتاهم يغير سلطان أتاهم كبر مقتل
+
+457
+00:59:27,380 --> 00:59:35,520
+عند الله وعند الذين آمنوا كذلك يقطع الله على كل
+
+458
+00:59:35,520 --> 00:59:44,950
+قلب متكبر جباه وقال فرعون ياوقال فرعونه رقيق الرقم
+
+459
+00:59:44,950 --> 00:59:51,330
+وقال فرعونه يا هامل ابنيلي صراحة لعلي ابلغ ال ..
+
+460
+00:59:51,330 --> 01:00:01,330
+لعلي ابلغ الأسباب الله يفتح عليك قلتيش؟ أسباب
+
+461
+01:00:01,330 --> 01:00:07,050
+.. أسباب .. أسباب السلامات فاططيع .. فاططيع
+
+462
+01:00:09,640 --> 01:00:16,900
+فأطلع إلى إله
+
+463
+01:00:16,900 --> 01:00:28,920
+موسى إلى إله موسى، مافيش يا إله إلى إله موسى،
+
+464
+01:00:28,920 --> 01:00:32,100
+مش إله، إلى إله موسى
+
+465
+01:00:34,690 --> 01:00:45,130
+فأفضر على إلهه إله .. إله وإني لأظنه كذبة لأظنه
+
+466
+01:00:45,130 --> 01:00:56,910
+كاذبة وإني لأظنه كاذبة لأظنه وإني لأظنه .. لأظنه
+
+467
+01:00:56,910 --> 01:01:05,680
+كاذبة وكذلك زي .. وكذلك زي .. وكذلك زي ..زينا
+
+468
+01:01:05,680 --> 01:01:15,680
+لفرعونا .. زينا .. فيش قلنا عليها شدة؟ زينا زينا
+
+469
+01:01:15,680 --> 01:01:21,900
+لفرعونا سوء
+
+470
+01:01:21,900 --> 01:01:22,580
+عمله
+
+471
+01:01:28,100 --> 01:01:37,020
+و جيبي المادة .. جيبي المادة المقتصرة سوقوا و
+
+472
+01:01:37,020 --> 01:01:39,380
+خد ده
+
+473
+01:01:44,150 --> 01:01:53,170
+وصد عن السبيل وما
+
+474
+01:01:53,170 --> 01:02:02,330
+كيدوا فرعون إلا في تمام وقال الذي آمن يا قوم
+
+475
+01:02:02,330 --> 01:02:08,670
+اتبعونه تابعوني أهديكم وقال الذي آمن يا قوم
+
+476
+01:02:08,670 --> 01:02:09,730
+اتبعونه
+
+477
+01:02:11,890 --> 01:02:22,110
+تبعوني أهديكم سبيل
+
+478
+01:02:22,110 --> 01:02:28,330
+الرشاد واضح الدال عشان فيها صوت القلق لابد أن انا
+
+479
+01:02:28,330 --> 01:02:40,490
+اوضحها سبيل الرشاد لأ برضه مش مبينةالرشادة تبيل
+
+480
+01:02:40,490 --> 01:02:50,090
+الرشاد
+
+481
+01:02:50,090 --> 01:02:53,930
+يا قوم
+
+482
+01:02:53,930 --> 01:02:58,490
+إنما هذه الحياة الدنيا متاعه
+
+483
+01:03:15,320 --> 01:03:17,820
+ما يفتح عليه؟
+
+484
+01:03:32,260 --> 01:03:42,080
+اقراي يا لينا يا تمي جاني ليلا
+
+485
+01:03:42,080 --> 01:03:47,160
+جرب ولّا قدامي مش عشان أسمع صوتك صوتك واضح الله
+
+486
+01:03:47,160 --> 01:03:53,240
+يبارك فيك الله
+
+487
+01:03:53,240 --> 01:04:00,740
+يرضى عامك يا عزيزي من عاملة؟من عاملة سيئة فلا
+
+488
+01:04:00,740 --> 01:04:11,820
+يُجزى من عاملة سيئة فلا يُجزى من عاملة سيئة فلا
+
+489
+01:04:11,820 --> 01:04:22,320
+يُجزى من عاملة سيئة فلا يُجزى إلا مثلها إلا مثلها
+
+490
+01:04:22,320 --> 01:04:26,500
+ومن
+
+491
+01:04:26,500 --> 01:04:27,880
+عاملة صالحة
+
+492
+01:04:31,240 --> 01:04:37,700
+أو أن ثا .. جبتي الاتفاق بجيبي حركتان أو أن ثا ..
+
+493
+01:04:37,700 --> 01:04:46,280
+و هو مؤمن .. و هو مؤمن فأولئك يدخلونا الجنة مد
+
+494
+01:04:46,280 --> 01:04:52,900
+المد فأولئك .. ايش نوع المد هنا؟ مدش مدسة .. مدسة
+
+495
+01:04:52,900 --> 01:04:56,940
+.. و هي مدسة .. و هي مدسة .. كلهم مغسسون
+
+496
+01:05:00,000 --> 01:05:08,020
+فأولئك يدخلون الجنة يرزقون .. اغني
+
+497
+01:05:08,020 --> 01:05:16,440
+عنهم يدخلون الجنة يدخلون الجنة يرزقون .. يرزقون
+
+498
+01:05:16,440 --> 01:05:23,500
+فيها بغير حساب ويا قوم ما لي أدعوكم .. ما لي
+
+499
+01:05:23,500 --> 01:05:25,360
+أدعوكم
+
+500
+01:05:28,840 --> 01:05:37,360
+لأ .. لأ أقرأي كويس كمان و يا قوم مالي أدعوكم إلى
+
+501
+01:05:37,360 --> 01:05:44,980
+النجاة و تدعوني .. إلى النجاة إلى النجاة و تدعوني
+
+502
+01:05:44,980 --> 01:05:54,760
+.. و تدعونني إلى .. و تدعونني إلى النار إلى النار
+
+503
+01:05:57,660 --> 01:06:03,220
+مش النار الالف ايه حكمها؟ مراقخة ولا مفخمة؟ مراقخة
+
+504
+01:06:03,220 --> 01:06:10,380
+اه، مناشي نقول النار، غلط الى النار الى النار
+
+505
+01:06:10,380 --> 01:06:18,900
+تدعونني لأكفرة مافيش ما تدعونني لأكفرة تدعونني
+
+506
+01:06:18,900 --> 01:06:24,080
+لأكفرة بالله و أشرك به ما ليس بيه بيه أوصلي ..
+
+507
+01:06:24,080 --> 01:06:29,650
+أوصلي و أشرك به ما ليسفقشت بيه ما ليس .. ما ليس لي
+
+508
+01:06:29,650 --> 01:06:36,470
+بيه علم و أنا .. و أنا .. و أنا أدعوكم الادف ثابتة
+
+509
+01:06:36,470 --> 01:06:40,450
+في حال الرسم العثماني و عند إيه؟ و عند الوصل لكن
+
+510
+01:06:40,450 --> 01:06:44,250
+.. و عند الوقف لكن عند الوصل و أنا أدعوكم، لا
+
+511
+01:06:44,250 --> 01:06:50,610
+تلفضت لعزيزي الغفار، لا جرم إنما .. لا جرم .. لا
+
+512
+01:06:50,610 --> 01:06:59,990
+جرم إنما تدعونني .. لا جرم ..أنما .. لأ جرم أنما
+
+513
+01:06:59,990 --> 01:07:07,390
+تدعونني إليه .. تدعونني إليه ليس لو دعوة في الدنيا
+
+514
+01:07:07,390 --> 01:07:15,510
+ولا في الآخرة وإنما .. وأنما ردنا .. وأنما ردنا
+
+515
+01:07:15,510 --> 01:07:25,150
+إلى الظالمين وأنما ..وأن المسرحين هم .. هم أصحاب
+
+516
+01:07:25,150 --> 01:07:30,170
+النار .. هم أصحاب النار، الله يفتح عليه
+
+517
+01:07:35,230 --> 01:07:42,330
+الله الرحمن الرحيم فستذكرون ما أقول لكم وفقد أمري
+
+518
+01:07:42,330 --> 01:07:49,790
+إلى الله إن الله بصير للعباد فوقاب الله سيئات ما
+
+519
+01:07:49,790 --> 01:07:54,150
+مكروا وحاق بآلة لعون سوء العذاب
+
+520
+01:07:56,390 --> 01:08:02,490
+وحاق بقال في رعونة سوء العذاب .. سوء العذاب مضمون
+
+521
+01:08:02,490 --> 01:08:07,110
+أنه نار يُعرضون عليها ويوم الصبح عشية .. الرأس
+
+522
+01:08:07,110 --> 01:08:12,820
+مضمون لازم نفخنها أن ناره يُعرضونالنار يُعرضون
+
+523
+01:08:12,820 --> 01:08:19,760
+عليها بدوا وعشي يوم ويوم تقوم الساعة ويوم تقوم
+
+524
+01:08:19,760 --> 01:08:24,000
+الساعة ويوم
+
+525
+01:08:24,000 --> 01:08:27,440
+تقوم الساعة
+
+526
+01:08:27,440 --> 01:08:33,600
+ويوم تقوم الساعة تدخلوا أدخلوا نمشد العدو ويوم
+
+527
+01:08:33,600 --> 01:08:47,980
+تقوم الساعة تدخلوا نمشد العدوو يوم تقوم الساعة
+
+528
+01:08:47,980 --> 01:08:57,280
+و ادخلوا آل فرعون عشان ده العذاب
+
+529
+01:09:20,260 --> 01:09:29,270
+دى بالاضاءة حركتين أنتم مغنونةفهل أنتم مغنون عن
+
+530
+01:09:29,270 --> 01:09:35,870
+نصيبك من النار؟ قولني عنه يعني من النار قال الذين
+
+531
+01:09:35,870 --> 01:09:44,730
+.. من النار من النار قال الذين استكبروا إن كلهم
+
+532
+01:09:44,730 --> 01:09:50,950
+فيها إن الله قد حكم بين العباد الله يفتح عليك كمية
+
+533
+01:09:50,950 --> 01:09:59,100
+أحلىأعوذ بالله من الشيطان الرجيم، وقال الذين في
+
+534
+01:09:59,100 --> 01:10:08,790
+تاني خزنة جهنم ادعو ربهم يطفف عنهأدعوا ربكم يقفز
+
+535
+01:10:08,790 --> 01:10:18,070
+عنا يوما يتعذابك قالوا أولمتوا
+
+536
+01:10:18,070 --> 01:10:26,290
+تأتيكم رسولكم بالبينات قالوا بلى قالوا فدعوا ما
+
+537
+01:10:26,290 --> 01:10:36,570
+دعاء الكافرين إلا في ضلالإننا لن .. إننا لن نصر ..
+
+538
+01:10:36,570 --> 01:10:42,570
+رسولنا .. إننا
+
+539
+01:10:42,570 --> 01:10:48,870
+لن نصر رسولنا والذين آمنوا في الحياة الدنيا ويوم
+
+540
+01:10:48,870 --> 01:10:55,830
+يقوموا الأشهاد يوم لا ينفعوا الظالمين معدى ربهم
+
+541
+01:10:55,830 --> 01:11:02,510
+ولهم اللعنة ولهم سوءالله يفتح عليك، خليني أنا أقف
+
+542
+01:11:02,510 --> 01:11:05,530
+عن هذا الموضوع عشان ده تبدأ قصة سيدنا موسى عليه
+
+543
+01:11:05,530 --> 01:11:08,710
+السلام، الله يفتح عليكم، برك الله فيكم، سبحان
+
+544
+01:11:08,710 --> 01:11:11,410
+الله، هم أبو حمد كاشر ولا إله إلا؟
+