entity_group score word start end file page_number 0 paratext 0.98543286 Accepted Manuscript, Molecular Phylogenetics and Evolution (online April 2020) 0 78 W3016250885.pdf 34 1 separator 0.49756005 79 80 W3016250885.pdf 34 2 paratext 0.9572772 "¶ Published version: https://www.sciencedirect.com/sc ience/article/pii/S1055790320300889 DOI: https://doi.org/10.1016/j.ympev.2020.106816 ¶ 34 This work is licensed under the Creative Commons Attribution ‐NonCommercial ‐ NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by ‐nc‐nd/3.0/" 80 442 W3016250885.pdf 34 3 separator 0.7310813 ¶ ¶ 443 449 W3016250885.pdf 34 4 bibliography 0.9862599 "Heibel, E. Wikramanayake, D. Olson, H. L. López, R. E. Reis, J. G. Lundberg, M. H. 673 Sabaj Pérez, and P. Petry. 2008. Freshwater Ecoregions of the World: A New Map of 674 Biogeographic Units for Freshwater Biodiversity Conservation. BioScience 58:403-414. 675" 449 718 W3016250885.pdf 34 5 separator 0.795616 ¶ 719 721 W3016250885.pdf 34 6 bibliography 0.9959927 "Agnese, J.-F. and G. G. Teugels. 2005. Insigh t into the phylogeny of African Clariidae 676 (Teleostei, Siluriformes): implications for their body shape evolution, biogeography, and 677 taxonomy. Molecular Phylogenetics and Evolution 36:546-553. 678" 721 977 W3016250885.pdf 34 7 separator 0.5638582 ¶ 978 980 W3016250885.pdf 34 8 bibliography 0.99777293 "Baric, S., W. Salzburger, and C. Sturmbauer . 2003. Phylogeography and evolution of the 679 Tanganyikan cichlid genus Tropheus based upon mitochondrial DNA sequences. Journal 680 of Molecular Evolution 56:54-68." 980 1198 W3016250885.pdf 34 9 separator 0.7371848 1198 1199 W3016250885.pdf 34 10 bibliography 0.8702685 681 1199 1202 W3016250885.pdf 34 11 separator 0.5992373 ¶ 1203 1205 W3016250885.pdf 34 12 bibliography 0.99710387 "Barnhart, M. C., W. R. Haag, and W. R. Roston. 2008. Adaptations to host infection and larval 682 parasitism in Unionoida. Journal of the North American Benthological Society 27:370- 683 394." 1205 1403 W3016250885.pdf 34 13 separator 0.6805196 1403 1404 W3016250885.pdf 34 14 bibliography 0.75509524 684 1404 1407 W3016250885.pdf 34 15 separator 0.5652816 ¶ 1408 1410 W3016250885.pdf 34 16 bibliography 0.99768806 "Bell-Cross, G. 1966. The distribution of fishes in Central Africa. Fisheries Research Bulletin 685 Zambia 4:3-20." 1410 1527 W3016250885.pdf 34 17 separator 0.6405474 1527 1528 W3016250885.pdf 34 18 bibliography 0.6880545 686 1528 1533 W3016250885.pdf 34 19 separator 0.6182366 ¶ 1533 1534 W3016250885.pdf 34 20 bibliography 0.9977329 "Bogan, A. E. and K. J. Roe. 2008. Freshwater bi valve (Unioniformes) diversity, systematics, and 687 evolution: status and future directions. Journal of the North American Benthological 688 Society 27:349-369." 1534 1750 W3016250885.pdf 34 21 separator 0.74284977 1750 1751 W3016250885.pdf 34 22 bibliography 0.891794 689 1751 1754 W3016250885.pdf 34 23 separator 0.56821215 ¶ 1755 1757 W3016250885.pdf 34 24 bibliography 0.99678093 "Bolotov, I. N., A. Kondakov, I. V. Vikhrev, O. V. Aksenova, Y. V. Bespalaya, M. Y. Gofarov, 690 Y. S. Kolosova, E. S. Konopleva, V. M. Spitsyn, K. Tanmuangpak, and S. 691 Tumpeesuwan. 2017. Ancient river inference explains exceptional oriental freshwater 692 mussel radiations. Scientific Reports 7:e2135 (doi: 2110.1038/s41598-41017-02312-z)." 1757 2111 W3016250885.pdf 34 25 separator 0.71125484 693 2111 2115 W3016250885.pdf 34 0 text 0.9914057 "189 which I was able to apply it the presence of fluid might have been determined beyond reasonable doubt. When properly checked by test and counter-test the paravertebral triangle is our finest and apparently our only reliable reagent for the detection of small amounts of free fluid at the base of the pleura and also for some estimate as to its quantity. This method of diagnosis is at the same time by far the easiest and the most rapid to carry out. It is, therefore, likely to be regarded in the future not only as important but as often indispensable." 0 578 W1580689211.pdf 0 1 separator 0.96433634 ¶ 578 580 W1580689211.pdf 0 2 contact 0.5722248 I am, Sirs, 580 592 W1580689211.pdf 0 3 text 0.5168855 your 592 597 W1580689211.pdf 0 4 contact 0.5636319 s 597 599 W1580689211.pdf 0 5 text 0.47303042 faith 599 604 W1580689211.pdf 0 6 contact 0.5504076 fully, 604 610 W1580689211.pdf 0 7 separator 0.48440176 610 611 W1580689211.pdf 0 8 contact 0.8038584 ¶ WILLIAM EWART. 611 627 W1580689211.pdf 0 9 separator 0.8570031 ¶ 627 629 W1580689211.pdf 0 10 contact 0.8574275 Curzon-street, Mayfair, W., July 14th, 1907. 629 674 W1580689211.pdf 0 11 separator 0.99172115 ¶ 674 676 W1580689211.pdf 0 12 title 0.9879617 THE TSETSE FLY. 676 692 W1580689211.pdf 0 13 separator 0.81947124 ¶ 692 694 W1580689211.pdf 0 14 title 0.97808903 To the Editors of THE LANCET. 694 724 W1580689211.pdf 0 15 separator 0.99195975 ¶ 724 726 W1580689211.pdf 0 16 text 0.99759936 "SIRS,-At a time when so much interest is being taken in the tsetse fly it may be of interest to some of your readers to make known publicly what I have already men- tioned to one or two medical friends. About three years ago (when I was travelling commissioner here) I asked somE native chiefs if they knevr the fly that did harm to then cattle. They said they did but that the fly did no damage unless it had pre2ioecsly bitten a ""red"" "" mon7aey. By this l think is meant a ""yellow monkey, not uncommon out her( (the natives have no names for different shades of colour af we have), and I never saw a "" red "" monkey. I give this fo] what it is worth, but there was no reason why a monke should have been mentioned any more than a goat unless thl natives thought there was some truth in the statement " 726 1554 W1580689211.pdf 0 17 separator 0.6547045 ¶ 1554 1555 W1580689211.pdf 0 18 text 0.99447465 "Westwood (‘‘ Introduction to Study of Insects"") mention: in a footnote that M. Vallot noticed the existence of al oestrideous larva in a monkey, and possibly it was a zimb The matter seems worth looking into at any rate." 1555 1782 W1580689211.pdf 0 19 separator 0.9863628 ¶ 1782 1784 W1580689211.pdf 0 20 contact 0.88010085 "I am, Sirs, yours faithfully, J. WINN SAMPSON, F.R.M.S., Police Magistrate." 1784 1864 W1580689211.pdf 0 21 separator 0.90225565 ¶ 1864 1866 W1580689211.pdf 0 22 contact 0.7675476 "Calabar, South Nigeria, June 14th, 1907.J. WINN SAMPSON, F.R.M.S., Police Magistrate." 1866 1954 W1580689211.pdf 0 23 separator 0.989151 ¶ 1954 1956 W1580689211.pdf 0 24 title 0.9884845 THE HAMPSTEAD GENERAL HOSPITAL. 1956 1988 W1580689211.pdf 0 25 separator 0.9500253 ¶ 1988 1990 W1580689211.pdf 0 26 title 0.9545637 To the Editors of THE LANCET. 1990 2020 W1580689211.pdf 0 27 separator 0.99181116 ¶ 2020 2022 W1580689211.pdf 0 28 text 0.99686813 "SiRS,-In your last issue Mr. A. Craske makes a great deal of what is obviously an error in the report of my speech. My assertion was that the income from the invested funds of the North-West London Hospital was under Z200 a year ; it is actually £170. I am, Sirs, yours faithfully," 2022 2318 W1580689211.pdf 0 29 separator 0.9708457 ¶ 2318 2320 W1580689211.pdf 0 30 contact 0.54170483 E. COLLINGWOOD ANDREWS. 2320 2344 W1580689211.pdf 0 31 separator 0.9288308 ¶ 2344 2346 W1580689211.pdf 0 32 bibliography 0.4911276 Hampstead 2346 2356 W1580689211.pdf 0 33 contact 0.6220586 , N.W., July 16t-h, 1907.E. COLLINGWOOD ANDREWS. 2356 2404 W1580689211.pdf 0 34 separator 0.99161404 ¶ 2404 2406 W1580689211.pdf 0 35 title 0.99198806 THE IMAGINATIVE TEMPER IN SCIENCE. 2406 2441 W1580689211.pdf 0 36 separator 0.9537947 ¶ 2441 2443 W1580689211.pdf 0 37 title 0.8602937 To the Editors of THE LANCET. 2443 2473 W1580689211.pdf 0 38 text 0.84617037 I 2473 2475 W1580689211.pdf 0 39 separator 0.8694222 ¶ 2475 2477 W1580689211.pdf 0 40 text 0.99938786 "SIRS,-I think homoeopaths will have good reason to grumble with your article on the Imaginative Temper in Science"" and to comment on the taste and tact of the writer and also of the Editor in introducing this subject into a leading article and making statements about it which its followers will be unable to controvert, not because they cannot, but because their replies would be boycotted, as this one will be, by the Editor who places as a motto over one of his columns ""Audi alteram partem."" """ 2477 2991 W1580689211.pdf 0 41 separator 0.96887314 ¶ 2991 2993 W1580689211.pdf 0 42 contact 0.8606634 I am, Sirs, your obedient servant, 2993 3028 W1580689211.pdf 0 43 separator 0.6233547 ¶ 3028 3030 W1580689211.pdf 0 44 contact 0.91479987 Dewsbury, July 14th, 1907. J. J. G. PRITCHARD. J. J. G. PRITCHARD. 3030 3097 W1580689211.pdf 0 45 separator 0.9894376 ¶ 3097 3099 W1580689211.pdf 0 46 title 0.99008155 "A NIGHT SHELTER FOR WOMEN AND GIRLS." 3099 3138 W1580689211.pdf 0 47 separator 0.9684198 ¶ 3138 3140 W1580689211.pdf 0 48 title 0.9437121 To the Editors of THE LANCET. 3140 3170 W1580689211.pdf 0 49 separator 0.9821216 ¶ 3170 3172 W1580689211.pdf 0 50 text 0.9957806 "SrRS,-We beg your courtesy for a little space in your valuable journal for a special appeal on behalf of a cheap and decent night shelter for women and girls which we are anxious to establish in London. The idea is the outcome of hundreds of sympathetic letters received since the publication of ""The Soul Market"" which gave Mrs. Archibald MacKirdy’s personal experiences among the poor and outcast. A lady has promised us R1000 if four other ladies or gentlemen will give or collect like sums. " 3172 3684 W1580689211.pdf 0 51 separator 0.52028733 ¶ 3684 3685 W1580689211.pdf 0 52 text 0.98893046 "The plans for the shelter are made on the most economical and practical lines. It is hoped it will, when built and equipped, be self-supporting. The charges will be 2d. to 4d. a night and this refuge will be the means of helping many agirl and woman back to good citizenship and decent living.We are favoured with Royal sympathy and our committee include the following ladies and gentlemen among others :- The Duchess of St. Albans, Lady Wemyss, Lady Brassey, Lady Evelyn Moreton, Lady Wright, Mrs. Herbert Gladstone, Lord Reay, Lord Curzon, Lord Brassey, Lord Strathcona, Sir W. Wright, Sir Dyce Duckworth, Sir W. S. Gilbert, and the Rav. Arch. Fleming." 3685 4358 W1580689211.pdf 0 53 separator 0.8732251 ¶ 4358 4360 W1580689211.pdf 0 54 text 0.58552164 "B Subscriptions may be sent to Lady Brassey, the treasurer of the fund, at, 24, Park-lane, London, W." 4360 4464 W1580689211.pdf 0 55 separator 0.94810104 ¶ 4464 4466 W1580689211.pdf 0 56 text 0.70383537 We are, Sirs, yours very truly, 4466 4498 W1580689211.pdf 0 57 contact 0.53248245 ¶ 4498 4500 W1580689211.pdf 0 58 text 0.58764434 SYBIL DE V. BRASSEY, 4500 4521 W1580689211.pdf 0 59 contact 0.66865265 ¶ 4521 4523 W1580689211.pdf 0 60 text 0.5906572 OLIVE CHRISTIAN MACKIRDY 4523 4548 W1580689211.pdf 0 61 contact 0.51994354 . 4548 4549 W1580689211.pdf 0 62 separator 0.9915026 ¶ 4549 4551 W1580689211.pdf 0 63 title 0.9852725 "THE REFORM OF THE ROYAL NAVY MEDICAL SERVICE." 4551 4599 W1580689211.pdf 0 64 separator 0.9340174 ¶ 4599 4601 W1580689211.pdf 0 65 title 0.97371703 To the Editors of THE LANCET. 4601 4631 W1580689211.pdf 0 66 separator 0.99091977 ¶ 4631 4633 W1580689211.pdf 0 67 text 0.9979082 "SIRS,-The Lords Commissioners of the Admiralty have just issued an order that naval medical officers are not to receive fees for evidence at coroner’s inquests or for performing post-mortem examinations on a coroner’s order, and that they are to consider this part of their duty as naval medical officers. I ask you to publish this letter because I think that this order may have been issued before their lordships had been sufficiently well advised upon the matter, and also in order that we may hear through your valuable columns the opinions of some of our brothers in the profession. I have always believed that on taking our diplomas to practise as medical men and becoming registered we were, partly by power of the Charter of the Medical Faculty to which we belonged and partly by right as a registered medical practitioner, entitled to certain privileges and at the same time bound by certain restrictions. The right to demand fees from a coroner I have always looked on as a right conferred by being a registered medical man. Surely, if one class of Government officials are to be debarred from receiving these fees that can only be done by Act of Parliament, which would alter the coroner’s law, and at the same time surely it should be made applicable to all paid out of the public purse, whether Admiralty, War Office, Local Government Board, or municipal authority." 4633 6060 W1580689211.pdf 0 68 separator 0.8868315 ¶ 6060 6062 W1580689211.pdf 0 69 text 0.9994611 "I regret to say that there is a feeling of uncertainty in our branch of the profession as to whether you would care to ventilate our grievances in your valuable journal owing to pressure from the medical department of the Admiralty, who are not anxious that candidates for the Service should be deterred from joining when they read what is published. As I am sure that you would not close your valuable journal to any true and sensible grievance I send you this letter. There is a widespread view,, that it is I quite time that the suggested reforms by which manywere lately induced to enter the Service should be brought in as there is a great desire for improvement by many, not in the direction of pay, rank, or privileges, but in promotion of efficiency throughout the Service. The open disapproval shown to men who endeavour to im- prove their general knowledge by working at bacteriology has caused much discontent. The present way of distri- buting hospital appointments which are so few as to be insufficient to enable every medical officer to obtain one during his whole career in the Service and which could so easily be remedied by shortening the term of office ; and in order to avoid long journeys and expense to the department in travelling exchanges could be effected every 12 months with men serving in the port or in the fleet attached to the station. The present system of employment of large numbers of medical officers in the home and reserve fleets which all have reduced crews and most of the home fleet ships having two medical officers. These fleets, the home and reserve, have not sufficient work for one man for three ships. It certainly shows the kindness and generosity of the Admiralty in keeping the officers on full pay, but I for one would much rather have efficiency than idleness, as once appointed to one of these ships one has to remain on board daily from 9 A.M. to 1.30 and most ships until 3.30, although there may not be one man sick and there is always one ship flying a medical guard flag which signifies an officer on board all day for emergency. There are many who suggest that in the case of these medical officers they should, after visiting their ship in order to see the sick, be appointed to the hospital as medical or surgical registrars in order to keep ¶" 6062 8445 W1580689211.pdf 0 0 paratext 0.97958285 Open Peer Review on Qeios 0 25 W4242450733.pdf 0 1 separator 0.66578716 25 26 W4242450733.pdf 0 2 paratext 0.89133036 ¶ Open Peer Review on Qeios 26 53 W4242450733.pdf 0 3 separator 0.96632874 ¶ 53 55 W4242450733.pdf 0 4 title 0.9902096 Intratendinous Route of Administration 55 94 W4242450733.pdf 0 5 separator 0.96841216 ¶ 94 96 W4242450733.pdf 0 6 title 0.5824433 National Cancer Institute 96 122 W4242450733.pdf 0 7 separator 0.94071764 ¶ 122 124 W4242450733.pdf 0 8 paratext 0.70399714 Source 124 131 W4242450733.pdf 0 9 separator 0.8243009 ¶ 131 133 W4242450733.pdf 0 10 paratext 0.5082299 National Cancer Institute. 133 160 W4242450733.pdf 0 11 separator 0.9865965 ¶ 161 163 W4242450733.pdf 0 12 title 0.9789749 Intratendinous Route of Administration 163 202 W4242450733.pdf 0 13 separator 0.6491721 ¶ 202 205 W4242450733.pdf 0 14 paratext 0.5985328 . NCI Thesaurus. Code 205 226 W4242450733.pdf 0 15 separator 0.32641232 ¶ 226 228 W4242450733.pdf 0 16 paratext 0.58255666 C38265. 228 236 W4242450733.pdf 0 17 separator 0.9918581 ¶ 236 238 W4242450733.pdf 0 18 text 0.9983085 "The administration of an agent within a tendon. The route is used for local therapy in various conditions of the tendinous or bursal structures such as tendinitis, tenosynovitis, epicondylitis, etc. Depending on indications and the drug, injection could be done into the tendon sheath or into the substance of the tendon." 238 566 W4242450733.pdf 0 19 separator 0.98284924 ¶ 566 568 W4242450733.pdf 0 20 paratext 0.9612743 "Qeios · Definition, February 7, 2020" 568 612 W4242450733.pdf 0 21 separator 0.5903174 612 613 W4242450733.pdf 0 22 paratext 0.93869704 "¶ Qeios ID: XQAZ9F · https://doi.org/10.32388/XQAZ9F 1 /" 613 677 W4242450733.pdf 0 23 separator 0.7886112 ¶ 677 679 W4242450733.pdf 0 24 paratext 0.676966 1 679 681 W4242450733.pdf 0 0 paratext 0.9720109 "9 Vol.:(0123456789) Scientific Reports | (2021) 11:21463 | https://doi.org/10.1038/s41598-021-99743-6" 0 112 W3210345755.pdf 8 1 separator 0.9944025 ¶ 112 114 W3210345755.pdf 8 2 text 0.99924934 "www.nature.com/scientificreports/Small angle neutron scattering. SANS measurements were performed in order to get further informa- tion on the structural organization of the optimized NLC, with and without tetracaine. The samples were pre- pared in D2O to reach a significant contrast between the solvent and the nanoparticles. First, all the NLC systems exhibit negligible changes when measurements were conducted at 25 °C and at 37 °C (as shown in Figure S1 for CP-DK/TTC and MM-DK/TTC). SANS data then revealed several systematic tendencies in the internal arrangement of the nanoparticles (Fig. 5). For those prepared with cetyl palmitate and Transcutol (CP-TRANS/ TTC, CP-TRANS) correlation peaks in the SANS curves indicated the existence of lamellar structures inside the NLC (Fig. 5A), in agreement with previous reports in the literature, obtained with Electron Paramagnetic Resonance45 and molecular Dynamics54. Indeed, among the blends of solid and lipid lipids tested, cetyl palmitate and TRANS have the largest difference in polarity, and their SL:LL molar ratio (0.66) was the smallest among the three optimized formulations (Table S3). Because of that, the lamellar structure revealed by SANS results from the reorganization of CP molecules in the lipid NLC core, avoiding the contact with TRANS molecules (see “Discussion” below). Interestingly, and in agreement with that, the Design of Experiments study revealed that only for the CP-TRANS formulation (Fig. 1A) the amount of solid lipid (CP) played a significant effect, determining increased particles size." 114 1737 W3210345755.pdf 8 3 separator 0.9956173 ¶ 1737 1739 W3210345755.pdf 8 4 caption 0.95620525 "Figure 5. SANS data, measured at 25 °C, for the optimized NLC formulations and their controls (without TTC): (A ) CP-TRANS, (B ) CP-DK, (C ) MM-DK. (D –F) Schematic representation of the lipid arrangements in the inner core of the three kind of nanoparticles (for the sake of clarify the surfactant molecules are not represented). Notice that a lamellar structure was detected in the core of CP-TRANS particles (D ) while" 1739 2171 W3210345755.pdf 8 5 text 0.6060396 2172 2173 W3210345755.pdf 8 6 caption 0.5073416 ¶ hydro 2173 2180 W3210345755.pdf 8 7 text 0.69825166 phobic clusters (dotted lines) were observed 2180 2224 W3210345755.pdf 8 8 caption 0.71345353 2224 2225 W3210345755.pdf 8 9 text 0.734613 between the lipids CP-DK 2225 2249 W3210345755.pdf 8 10 caption 0.53396946 ( 2249 2251 W3210345755.pdf 8 11 text 0.53033745 E 2251 2253 W3210345755.pdf 8 12 caption 0.61609775 ) and 2253 2258 W3210345755.pdf 8 13 text 0.6191234 MM-DK systems 2258 2272 W3210345755.pdf 8 14 caption 0.5990113 ( 2272 2274 W3210345755.pdf 8 15 text 0.70425904 F 2274 2275 W3210345755.pdf 8 16 caption 0.5423516 ). 2275 2278 W3210345755.pdf 8 0 paratext 0.96445364 "25 ¶ Ethiopian Medical Journal 2024, 62(1) Open access articles distributed in terms of Creative Commons Attribution Licence [CC by 4.0] https://dx.doi.org/10.4314/emj.v62i1.4 ISSN 0014 -1755 eISSN 2415 -2420 Ayele et al. ¶" 0 260 W4391222929.pdf 0 1 separator 0.4927788 262 263 W4391222929.pdf 0 2 paratext 0.5874188 ¶ Original 263 273 W4391222929.pdf 0 3 title 0.49381852 Article 274 282 W4391222929.pdf 0 4 separator 0.6116015 ¶ ¶ 284 290 W4391222929.pdf 0 5 title 0.9730166 "Factors Associated with Neurocognitive Impairment in Treatment Experienced HIV+ Adults from a Tertiary Care Center in Ethiopia" 290 433 W4391222929.pdf 0 6 separator 0.98514235 ¶ 435 437 W4391222929.pdf 0 7 contact 0.98551273 "Biniyam A. Ayele1*, Kiran T. Thakur2, Wondwossen Amogne3 1Department of Neurology, School of Medicine, College of Health Sciences, Addis Ababa University 2 Department of Neurology, Columbia University Irving Medical Center, NY, USA 3 Department of Internal medicine, School of Medicine College of Health Sciences Addis Ababa University, Addis Ababa, Ethiopia ¶ Corresponding authors*: biniyam.a7@gmail.com" 437 881 W4391222929.pdf 0 8 separator 0.8493654 ¶ ¶ 883 889 W4391222929.pdf 0 9 title 0.93400407 Abstract 889 898 W4391222929.pdf 0 10 separator 0.99446297 ¶ 900 902 W4391222929.pdf 0 11 text 0.9986704 "Background: Given the improvement in life expectancy of people living with HIV (PLWH) in sub -Saharan Afri - ca, the risk of asymptomatic HIV -associated neurocognitive disorder (HAND) has increased. The study objectives were to investigate the prevalence of HAND and associated factors among treatment experienced adults in Ethiopia." 902 1257 W4391222929.pdf 0 12 separator 0.75422 ¶ 1259 1261 W4391222929.pdf 0 13 text 0.9992149 "Methods: A single -center observational cross -sectional study was conducted between December 2019 and June 2020 to investigate HAND. International HIV dementia scale (IHDS) was used to screen for the dis order. Both descriptive and analytical statistics were used to analyze the data." 1261 1560 W4391222929.pdf 0 14 separator 0.9196341 ¶ 1562 1564 W4391222929.pdf 0 15 text 0.9994939 "Results: Total of 324 PLWH (63% females) who were on combination antiretroviral therapy for median of 144 months (IQR: 108 -168) were investigated. The mean age was 42.5 years (1SD=12.2). The prevalence of HAND was 75.3% and the difference was significantly more in those above 40 years of age (65.8% vs. 80.7%, p=0.003)." 1564 1894 W4391222929.pdf 0 16 separator 0.78631496 ¶ 1896 1898 W4391222929.pdf 0 17 text 0.9995162 "Age is the only risk factor identified with multivariable logistic regression analysis. A linear decrement in the total score of cognitive performance was observed as the patient’s age increase; age was responsible for 9.4% variation observed in IHDS score (r= -0.31, R2=0.094, p<0.0001). Although statistically not -significant, the trend for cardio - metabolic and behavioral risk factors (hypertension, diabetes mellitus, dyslipidemia, smoking, alcohol and khat use) was higher in the group diagnosed with HAND." 1898 2439 W4391222929.pdf 0 18 separator 0.8626594 ¶ 2441 2443 W4391222929.pdf 0 19 text 0.9993185 "Conclusion: The occurrence of neurocognitive impairment was more pronounced in individuals aged 40 years and above who were HIV positive, compared to those below 40 years. Age was found to be an independent predictor of HAND. Cardiovascular and behavioral risk factors were observed more among patients with HAND compared to no-HAND." 2443 2791 W4391222929.pdf 0 20 separator 0.9397951 ¶ ¶ 2793 2799 W4391222929.pdf 0 21 paratext 0.43374917 Keywords : 2799 2810 W4391222929.pdf 0 22 text 0.3330362 HIV -associated neur oc 2810 2834 W4391222929.pdf 0 23 paratext 0.28310394 ognitive 2834 2842 W4391222929.pdf 0 24 text 0.34422725 disorder; aging; cardiovascular 2842 2874 W4391222929.pdf 0 25 paratext 0.3254781 risk factors 2874 2887 W4391222929.pdf 0 26 text 0.29643047 ; behavior 2887 2897 W4391222929.pdf 0 27 paratext 0.34866476 al risk factors; 2897 2916 W4391222929.pdf 0 28 separator 0.4642772 ¶ 2916 2917 W4391222929.pdf 0 29 paratext 0.5995537 Ethiopia 2917 2926 W4391222929.pdf 0 30 separator 0.97028434 ¶ 2928 2930 W4391222929.pdf 0 31 paratext 0.82934 "Citation : Ayele BA, Thakur KT, Amogne W et al. Factors associated with neurocognitive impairment in treatment experienced HIV+ adults from a tertiary care center in Ethiopia: A perspective study. Ethiop Med J 62 (1) 25 - 31" 2930 3172 W4391222929.pdf 0 32 separator 0.82607746 ¶ 3173 3175 W4391222929.pdf 0 33 paratext 0.97993904 Submission date : 14 March 2023 Accepted: 22 November 2023 Published: 1 January 2024 3175 3268 W4391222929.pdf 0 34 separator 0.98263836 ¶ ¶ 3270 3276 W4391222929.pdf 0 35 title 0.93846667 Introduction 3276 3289 W4391222929.pdf 0 36 separator 0.9935709 ¶ 3291 3293 W4391222929.pdf 0 37 text 0.99552745 "HIV-associated neurocognitive disorder is an umbrella term, which includes asymptomatic neurocognitive im - pairment (ANI), mild neurocognitive disorder (MND), and HIV-associated dementia (HAD) in individuals suffering from chronic HIV infection (1–3). Post com - bination antiretroviral therapy (cART) era is characterized by relati ve decrement in incidence of the severe form of HAND (i.e., HAD) and increment in incidence of ANI and MND (1–3). Likewise, the overall prevalence of HAND has remained similar in the post -cART era with almost affecting half of HIV infected individuals (1–3). Early identification of those at risk, accurate diagnosis, and treatment of HAND is vital especially in low and middle income (LMIC) countries such as Ethiopia, where HAND related health bur- den is highest (3). ¶ Prior studies have identified that decline in cognitive function of HIV + patients were strongly associated with poor cART adherence, engaging in unsafe sex, substance abuse, alcohol addiction, and loss to follow up; ultimately resulting in poor quality of life and increased HIV-associated morbidity and" 3293 4529 W4391222929.pdf 0 0 text 0.9922682 "Figure 4b, c characterize the catalytic nitroce fin hydrolysis, induced by the amine-substituted mutants. In general, all amine-substitutions led to a decrease in the catalytic activity in comparison tothe parent PSM α3. Speci fically, α3-N.Ac., α3-K6A, α3-K9A, and α3-K17A displayed minimal degradation of nitroce fin after two hours, re flected in the low concentration of the degradation product and low V 0values." 0 421 W4389556171.pdf 6 1 separator 0.94521296 ¶ 421 423 W4389556171.pdf 6 2 text 0.9979561 "These findings indicate that the primary amines of the N-terminus and t h es i d ec h a i n so fK 6 ,K 9 ,a n dK 1 7p l a yc r i t i c a lr o l e si nt h ec a t a l y t i cactivity of PSM α3fibrils. Interestingly, α3-K12A fibrils exhibited more pronounced catalytic activity alb eit lower than the parent peptide, generating 70% substrate degradation after two hours and indicatingthat K12 differs in its contribution to the catalytic active site and/or thereaction mechanism. pH titration experiments (Fig. S10) reveal that thepKa values of the amine moieties in the PSM α3fibrils were close to physiological pH (7.4), indicating ready occurrence of deprotonation, thereby enhancing the nucleophilic properties of the lysine residues (Fig. S10)." 423 1178 W4389556171.pdf 6 3 separator 0.98377323 ¶ 1178 1180 W4389556171.pdf 6 4 text 0.99856484 "Molecular dynamics (MD) simulations were carried out, designed to probe the nitroce fin binding modality onto the surface of PSM α3 fibrils, and furnishing a comprehensive overview of the structural and mechanistic features of the catalytic process (Fig. 5). To facilitate the MD analysis, we constructed a minimal representation of the amyloidsurface (Fig. 5a) and placed nitroce fin in an unbound state approxi- mately 2 nm from the surface (Fig. S11). We then aggregated 100 μso f simulation time over 20 repeat simulations of the binding processobtaining extensive sampling of ligand adsorption, binding con- formations, and transitions between them." 1180 1846 W4389556171.pdf 6 5 title 0.9344173 "Binding site clustering using the PyLipID software" 1846 1899 W4389556171.pdf 6 6 separator 0.94661546 ¶ 1899 1901 W4389556171.pdf 6 7 text 0.9993548 "58reveals two distinct bound conformations (Fig. 5bi,ii) based on the longest average binding duration of nitroce fin, which is ~300 ns for both sites. Inspection of the bound conformationsindicates that distinct structural features are shared between theconformations. Speci fically, the two bound nitroce fin conformations are anchored in the cavity between two PSM α3 helices by the thio- phene moiety, which binds in a hydrophobic pocket consisting ofphenylalanine F8 and F10. Likewise, the dinitrostyryl moiety binds inthe F8, F10 pocket in both conformations, but in the adjacent cavity tothe thiophene. Interestingly, the conformations mainly differ in the orientation of the β-lactam carbonyl of the 4-membered ring that is susceptible to be hydrolyzed resulting in nitroce find e g r a d a t i o n .I nt h e first binding site the carbonyl binds the two central lysines, K9 and K12 (Fig. 5b,i), while in the second site, the carbonyl binds to the N-terminal primary amine of methionine M1 and lysine K6 (Fig. 5b,ii). Given the very slow turnover, covalent trapping of β-lactam intermediates may occur, accounting for the nucleophilic properties of the lysines." 1901 3088 W4389556171.pdf 6 8 separator 0.9957839 ¶ 3088 3090 W4389556171.pdf 6 9 caption 0.9900359 "Fig. 5 | Molecular Dynamics (MD) simulations of nitroce fin binding to PSM α3 amyloid fibrils ’surface. a The cross- αamyloid fibrils of PSM α3, composed of bilayer made of amphiphilic α-helices, display arrays of lysine residues (marked in purple, based on PDB structure 5I5523).bMD simulations reveal two distinct binding conformations of nitroce fint ot h e fibril surface (conformation (i) and (ii))." 3090 3498 W4389556171.pdf 6 10 separator 0.9532677 ¶ 3498 3500 W4389556171.pdf 6 11 text 0.7670984 In both conformations, the β-lactam ring binds the primary amines of PSM α3(β-lactam carbonyl marked with 3500 3606 W4389556171.pdf 6 12 caption 0.8236733 3606 3607 W4389556171.pdf 6 13 text 0.5846101 a black arrow). 3607 3622 W4389556171.pdf 6 14 caption 0.9940942 "cThe fraction of contacts between the β-lactam carbonyl and the peptide residues, calculated with a 0.45 nm contact cutoff. dThree-state Bayesian Markov State Model between the unbound state and the bound states M1|K6 ( b, right) and K9|K12 ( b, left). The free energy for each state at 20oC and transition rates between the states were calculated from the MSM transition matrix. The sample standard deviation is shown in parentheses." 3622 4067 W4389556171.pdf 6 15 paratext 0.75708497 Article https://doi.org/10.1038/s41467-023-43624-1 4067 4117 W4389556171.pdf 6 16 separator 0.92541534 ¶ 4117 4119 W4389556171.pdf 6 17 paratext 0.98070455 Nature Communications | (2023) 14:8198 7 4119 4168 W4389556171.pdf 6 0 paratext 0.98431116 376 Arq Neuropsiquiatr 2022;80(4):375-383 0 41 W4224275305.pdf 1 1 title 0.82519644 INTRODUCTION 41 53 W4224275305.pdf 1 2 separator 0.9963007 ¶ 53 55 W4224275305.pdf 1 3 text 0.9985329 "The World Health Organization (WHO) declared that COVID- 19 constituted a pandemic on March 11, 20201. According to WHO data, the virus had infected 172,956,039 people worldwide as of June 7, 2021, and had caused 3,726,466 deaths2." 55 295 W4224275305.pdf 1 4 separator 0.7776567 ¶ 295 297 W4224275305.pdf 1 5 text 0.99745154 "Two coronaviruses previously identified as SARS-CoV-1 and MERS-CoV have caused large-scale epidemics3,4. SARS- CoV-2 may have higher neuroinvasive potential than previ- ous coronaviruses5." 297 493 W4224275305.pdf 1 6 separator 0.92349476 ¶ 493 495 W4224275305.pdf 1 7 text 0.9996254 "Viruses enter the central nervous system (CNS) essen - tially through hematogenous and neuronal retrograde prop - agation pathways. SARS-CoV-2 can also bind to angioten- sin receptor 2 (ACE2), which is expressed in the capillary endothelium of the blood brain barrier (BBB), to access the CNS6,7. The ACE2 receptor is expressed intensely in the cer - ebellum, thalamic nuclei, inferior olivary nucleus, ventro- lateral medulla and tractus solitarius nucleus, in the CNS1,8." 495 986 W4224275305.pdf 1 8 separator 0.71375173 ¶ 987 989 W4224275305.pdf 1 9 text 0.9992317 "SARS-CoV-2 has higher affinity for the ACE2 receptors found in neurons and endothelial cells than does SARS-CoV-17." 989 1108 W4224275305.pdf 1 10 separator 0.91589606 ¶ 1109 1111 W4224275305.pdf 1 11 text 0.99930733 "The mechanisms that have been suggested for the devel- opment of various neurological syndromes include direct viral neuronal damage, a hyperinflammatory syndrome secondary to viremia, para-infectious and post-infectious inflammatory or immune-mediated disorders, sepsis, hyper - pyrexia, hypoxia, hypercoagulopathy and critical illness." 1111 1462 W4224275305.pdf 1 12 separator 0.77858996 ¶ 1463 1465 W4224275305.pdf 1 13 text 0.99907374 "Several neurological conditions, including encephalopathy, meningoencephalitis, ischemic stroke, acute necrotizing encephalopathy and Guillain-Barré syndrome (GBS), have been found to coexist with COVID-199." 1465 1682 W4224275305.pdf 1 14 separator 0.8364374 ¶ 1682 1684 W4224275305.pdf 1 15 text 0.9992947 "Considering the high rates of COVID-19 infection in the general population, it is important to distinguish whether COVID-19 is associated with neurological involvement or whether coexistence of neurological diseases is coincidental, with support from scientific data10." 1684 1966 W4224275305.pdf 1 16 separator 0.9734254 ¶ 1966 1968 W4224275305.pdf 1 17 text 0.99889463 "In our study, we retrospectively reviewed the files of 2,329 patients who had been diagnosed with COVID-19 pneu- monia and hospitalized in the wards or intensive care units (ICUs) of our institution. We conducted statistical analyses on the data regarding neurological findings, demographic data, relationships with other chronic diseases, radiology and laboratory findings and drug use, with regard to 154 patients who required neurological consultations (NC)." 1968 2450 W4224275305.pdf 1 18 separator 0.99600303 ¶ 2451 2453 W4224275305.pdf 1 19 title 0.99012876 METHODS 2453 2461 W4224275305.pdf 1 20 separator 0.996727 ¶ 2461 2463 W4224275305.pdf 1 21 text 0.99951065 "The files of 2,329 patients with a diagnosis of COVID-19 pneumonia who were hospitalized in the wards and ICUs of our institution, between March 23, 2020, and October 1, 2020, were examined. The clinical findings, radiological find- ings and treatment records of 154 patients who required NC due to neurological symptoms were screened retrospec- tively by evaluating the consultation notes and patient files. The reason for requesting NC, neurological diagnoses, neu- rological examination findings and radiological data of all patients were examined. Patients under 18 years of age, those with a negative PCR test and/or without findings compatible with COVID-19 pneumonia on chest computed tomography imaging were not included in the evaluation." 2463 3241 W4224275305.pdf 1 22 separator 0.76210237 ¶ 3241 3243 W4224275305.pdf 1 23 text 0.993455 "The study protocol was approved by the Republic of Turkey Ministry of Health Scientific Research Platform and by Firat University Medical School Clinical Research Ethics Board." 3243 3429 W4224275305.pdf 1 24 separator 0.97837734 ¶ 3430 3432 W4224275305.pdf 1 25 text 0.9995802 "The age, sex, ICU admission and length of hospitalization of the patients who required NC were evaluated. The PCO2, pH, PaO2/FiO2 ratio, positive end expiratory pressure (PEEP), oxygen saturation, lymphocyte, white blood cell (WBC), thrombocyte, ferritin, D-dimer, pro-brain natriuretic peptide (pro-BNP), fibrinogen and C-reactive protein (CRP) values of the patients were recorded. The treatments that they received were recorded. The frequencies of neurological or non-neu- rological chronic comorbid diseases among the patients in this group were examined. The neurological findings mag - netic resonance imaging (MRI), CT, electroencephalography (EEG) and electromyography (EMG) findings of the patients were evaluated. The demographic data, risk factors, treat- ments and radiological and laboratory findings of patients who were diagnosed with delirium, acute ischemic or hemor - rhagic stroke were evaluated. Delirium patients were identi- fied by using the Richmond Agitation Sedation Scale (RASS)." 3432 4483 W4224275305.pdf 1 26 separator 0.971695 ¶ 4484 4486 W4224275305.pdf 1 27 text 0.99958426 "RASS is a 10-point scale, where (0) indicates a calm and alert state, while the levels from +1 to +4 indicate increasing lev- els of agitation and the levels from -1 to -5 indicate increas- ing levels of sedation11. It has been stated that patients with RASS scores between -4 and +4 can be evaluated as having delirium12." 4486 4822 W4224275305.pdf 1 28 separator 0.9966759 ¶ 4823 4825 W4224275305.pdf 1 29 title 0.99035054 Statistical analysis 4825 4846 W4224275305.pdf 1 30 separator 0.99534845 ¶ 4846 4848 W4224275305.pdf 1 31 text 0.9997135 "The data were analyzed by using the Statistical Package for the Social Sciences (SPSS) v.22 software (SPSS Inc., Chicago, IL, USA) Descriptive statistics were expressed as the number and percentage for categorical data and as the mean ±standard deviation for continuous data. Pearson chi- square analysis was used to compare categorical variables between groups. The Kolmogorov-Smirnov test was used to evaluate the normality of distribution of continuous vari- ables. The one-way ANOVA test was used to compare the nor - mally distributed numerical measurements in more than two groups. Student’s t-test was used for comparison of paired groups. P<0.05 were accepted as statistically significant." 4848 5576 W4224275305.pdf 1 32 separator 0.9953648 ¶ 5577 5579 W4224275305.pdf 1 33 title 0.99091166 RESUL TS 5579 5588 W4224275305.pdf 1 34 separator 0.9966548 ¶ 5588 5590 W4224275305.pdf 1 35 text 0.9992054 "The files of a total of 2,329 COVID-19 pneumo- nia patients were screened in this study. The number of patients who required NC was 154. NC were requested for" 5590 5754 W4224275305.pdf 1 0 paratext 0.70623016 Мамитова Н. В. и др. Использование инструментов цифровой экономики в контексте минимизации коррупционных рисков 0 119 W2898330393.pdf 4 1 separator 0.77566314 ¶ 121 126 W2898330393.pdf 4 2 paratext 0.7709658 ¶ 7 126 129 W2898330393.pdf 4 3 separator 0.9911723 ¶ 130 132 W2898330393.pdf 4 4 text 0.99923116 "Не случайно о необходимости усиления борьбы с коррупцией неоднократно ука- зывалось Президентом Российской Феде - рации В. В. Путиным и другими государ - ственными и политическими лицами на- шего государства1." 133 370 W2898330393.pdf 4 5 separator 0.84705174 ¶ 371 373 W2898330393.pdf 4 6 text 0.9990227 "Законодателем предпринимаются по- пытки сформулировать понятие этого не- гативного явления и определить норма - тивно -правовые контуры противодействия коррупции . Так, в действующем законода - тельстве под термином «коррупция » по- нимаются злоупотребление служебным положением , дача взятки , получение взят - ки, злоупотребление полномочиями , ком- мерческий подкуп или иное незаконное использование физическим лицом своего должностного положения вопреки закон - ным интересам общества и государства в целях получения выгоды в виде денег , ценностей , иного имущества или услуг имущественного характера , иных имуще - ственных прав для себя или для третьих лиц, либо незаконное предоставление та- кой выгоды указанному лицу другими фи- зическими лицами , либо совершение дея- ний , указанных выше , от имени или в ин- тересах юридического лица [3. – C. 388]." 373 1349 W2898330393.pdf 4 7 separator 0.9877551 ¶ 1350 1352 W2898330393.pdf 4 8 text 0.9992853 "В результате сложившихся на сего - дняшний день социальных , экономиче - ских , политических и правовых условий в стране наиболее эффективными мерами борьбы с коррупцией являются не уголов - ные, а гражданско -правовые методы . Ука- занное положение находит отражение в научных исследованиях . В свое время Н. М. Коркунов отмечал , что уголовная кара не восстанавливает нарушенного права и не возмещает вред , причиненный преступником [4. – С. 694]. Ученые пола - гают , что процесс реализации уголовно - правовых норм достаточно сложен , а самое главное – не гарантирует ожидаемых ре- зультатов из-за отсутствия материальных и кадровых ресурсов и в целом низкой эф- фективности работы правоохранительной" 1352 2151 W2898330393.pdf 4 9 separator 0.96121716 ¶ ¶ 2153 2207 W2898330393.pdf 4 10 bibliography 0.9564299 "1 См.: Послание Президента Владимира Путина Фе- деральному Собранию Российской Федерации // Российская газета . – 2012. – 13 декабря . системы" 2207 2364 W2898330393.pdf 4 11 text 0.4942169 2364 2365 W2898330393.pdf 4 12 bibliography 0.42812002 , поскольку 2365 2376 W2898330393.pdf 4 13 text 0.40686226 она 2377 2381 W2898330393.pdf 4 14 bibliography 0.42754683 в первую очередь 2381 2402 W2898330393.pdf 4 15 text 0.44782588 ¶ 2402 2403 W2898330393.pdf 4 16 bibliography 0.45865253 подвержена « 2403 2417 W2898330393.pdf 4 17 text 0.4337344 коррупци 2417 2425 W2898330393.pdf 4 18 bibliography 0.48397475 онной 2425 2432 W2898330393.pdf 4 19 text 0.42088 эрозии 2432 2438 W2898330393.pdf 4 20 bibliography 0.45869637 2438 2439 W2898330393.pdf 4 21 text 0.55656505 ». 2439 2441 W2898330393.pdf 4 22 separator 0.97590137 ¶ 2442 2444 W2898330393.pdf 4 23 text 0.9968955 "Особенно подчеркивается , что перекос в сторону уголовного права , уверенность , что уголовное наказание эффективно обеспечит как общую , так и частную пре- венцию , привели к тому , что наше право не имеет развитой системы гражданско - правовых средств противодействия кор- рупции [5. – C. 267]." 2444 2778 W2898330393.pdf 4 24 separator 0.98838544 ¶ 2780 2782 W2898330393.pdf 4 25 text 0.99926937 "Коррупция – многовекторное явление социальной действительности . С помощью состава преступления , по мнению специа - листов -практиков (не теоретиков уголов - ного права ), нельзя определить ее общест - венную опасность . С. С. Алексеев справед - ливо указывает на необходимость прини - мать во внимание в процессе действия по- зитивного права многообразие фактов со- циальной практики : экономических , поли - тических , психологических , индивидуаль - но-житейских и многих других [1. – С. 39]." 2782 3332 W2898330393.pdf 4 26 separator 0.9889816 ¶ 3333 3335 W2898330393.pdf 4 27 text 0.9993268 "Мы полагаем , что правильнее было бы на- звать это революционное для правоприме - нительной практики явление не социаль - ным составом преступления , а социальным составом правонарушения и в зависимости прежде всего от личности правонарушите - ля в подавляющем большинстве случаев применять гражданско -правовые меры и только в исключительных – уголовно - правовые . Также мы считаем , что, во- первых , уголовное наказание , связанное с лишением свободы , не обеспечит исправ - ление коррупционера , а скорее наоборот – укрепит в его поведении антиобществен - ные установки ; во-вторых , борьба с кор- рупцией уголовно -правовыми методами – это чаще всего видимость борьбы , по- скольку не секрет , что на муниципальном уровне нередко существует круговая по- рука среди чиновников , которая не позво - ляет изобличить своих и порушить моно - литные ряды так называемой местничковой элиты ; в-третьих , уголовное наказание , как правило , не предполагает абсолютной конфискации всего незаконно нажитого имущества коррупционера и имущества , находящегося в его родственных кланах ." 3335 4550 W2898330393.pdf 4 0 text 0.9985519 "km, and the average household size is 5.58. The literacy rate of this district is 35%. In this district, 87% of the population is Muslim, 13% Hindu, 0.1% Christian and 0.002% Buddhist (BBS, 2013)" 0 197 W2228033673.pdf 3 1 separator 0.54522806 197 198 W2228033673.pdf 3 2 text 0.99855375 "¶ [11]. Most of the people in study areas are involved with agricultural activities. We conducted this study in three sub-districts of Sunamgonj district. Most of the roads in the study areas aremade of mud, some of which are broken. The entire study area remains under water for half of the year. It is very difficult to move from one place to another in the villages during the rainy sea- son; villagers have to use bamboo bridges to cross the haors or marshy areas. During the rainy season, the only form of transportation is boat, without which one cannot move from one place to another. However, boats are not always available. After the rainy season is over, villagers mostly move from one place to another on foot. The only vehicle used is the motorbike whichpregnant women cannot easily use, especially as the road remains dilapidated long after the rainy season is over. Therefore, poor road conditions and lack of availability of transportation in both the rainy and dry seasons deter women from seeking facility based maternal and child healthcare in this study area. Residents of the study area usually seek health services from informal pro- viders such as: village doctors or drug sellers in and around the community." 198 1447 W2228033673.pdf 3 3 separator 0.9968202 ¶ 1447 1449 W2228033673.pdf 3 4 title 0.99148536 Study participants and sampling procedure 1449 1491 W2228033673.pdf 3 5 separator 0.99581355 ¶ 1491 1493 W2228033673.pdf 3 6 text 0.99946535 "We included several categories of study participants such as stakeholders which included influen- tial community members, formal and informal maternal and child health (MCH) service provid-ers, as well as community women. Stakeholders included Upazila Nirbahi Officers (UNO), Upazila Chairman, and Union Parisad (UP) chairman, UP member, as well as community influ- ential persons such as Imamas (Muslim religious leader) and teachers. As part of the formalMCH service providers we interviewed government Family Welfare Assistants (FWAs), FamilyWelfare Visitors (FWVs), Health Assistants (HAs), Upazila Family Planning Officers (UFPOs), Upazila Health & Family Planning Officers (UH&FPOs), obstetrics and gynecology consultants and nurses. We interviewed Village Doctors (VDs) and Traditional Birth Attendants (TBAs) asinformal MCH service providers. Finally, we interviewed community women with at least one living child below one year of age at the time of interviews to get their own experiences and per- ceptions regarding home delivery and preferences for TBAs. We applied a snowball samplingtechnique to identify the eligible respondents for both KIIs and IDIs. This snowball sampling approach helped us to easily identify eligible respondents. Those TBAs and VDs who were most popular or who conducted or assisted with high volume delivery in the last one year were identi-fied and selected as study participants and identified based on discussions with the local commu- nity. While qualitative study participants were purposively selected in the field, several eligibility criteria were used as a sampling frame including: education for the women ( <5v s .>5 class); years of involvement as community leader for the local elite e.g., UP member, Chairman, Imam,Teacher, etc; job duration for the formal and informal health service providers (experience for 5 years or more) in the maternal and child health and Family Planning field. We used purposive sampling to select the respondents in consultation with the community people living in the studyarea who could provide the most appropriate information to serve the purpose of the study. We shared our study objectives among the community people and asked them to let us know who would be best person to discuss on this issue. Therefore, community people themselves identifiedthe key informants and based on our selection criteria we went to respective informants to con- duct interviews. A detailed sampling frame is presented in Fig 1 ." 1493 4024 W2228033673.pdf 3 7 separator 0.99755543 ¶ 4024 4026 W2228033673.pdf 3 8 title 0.98887604 Sample Size 4026 4038 W2228033673.pdf 3 9 separator 0.9964796 ¶ 4038 4040 W2228033673.pdf 3 10 text 0.99550235 "We conducted 21 KIIs with stakeholders, 21 KIIs with formal health service providers, and 12 KIIs with informal providers at the community and facility level. In addition, 12 IDIs with Preference for Home Delivery with TBA in Rural Bangladesh" 4040 4287 W2228033673.pdf 3 11 separator 0.9494537 ¶ 4287 4289 W2228033673.pdf 3 12 paratext 0.98860085 PLOS ONE | DOI:10.1371/journal.pone.0146161 January 5, 2016 4/1 9 4289 4355 W2228033673.pdf 3 0 bibliography 0.98963165 "Okusaga O, Yolken R, Langenberg P ,et al. (2011). Association with seropositivity for influenza andcoronaviruses with history of mood disorders andsuicide attempts. Journal of Affective disorders 130(1–2), 220 –225." 0 219 W3025453843.pdf 5 1 separator 0.9837221 ¶ 219 221 W3025453843.pdf 5 2 bibliography 0.99769783 "Pivonello R, Simeoli C, Cristina de Martino M ,et al. (2015). Neuropsychiatric disorders in Cushing ’s syndrome. Frontiers in Neuroscience 9, 129. Published online 2015 Apr 20. doi: 10.3389/fnins.2015.00129 ." 221 436 W3025453843.pdf 5 3 separator 0.9851445 ¶ 436 438 W3025453843.pdf 5 4 bibliography 0.99785167 "Rasa S, Nora-Krukle Z, Henning N, Eliassen E, Shikova E, Harrer T, Scheibenbogen C, Murovska M, Prusty BK(2018). Chronic viral infections in myalgicencepaholmyelitis/chronic fatigue syndrome. Journal of Translational Medicine 16(268). doi: 10.1186/s12967-018- 1644-y ." 438 713 W3025453843.pdf 5 5 separator 0.9840871 ¶ 713 715 W3025453843.pdf 5 6 bibliography 0.9981218 "Straus SE, Tosato G, Armstrong G ,et al. (1985). Persisting illness and fatigue in adults with evidence of Epstein-Barrvirus infection. Annals of Internal Medicine 102,7–16." 715 891 W3025453843.pdf 5 7 separator 0.9814879 ¶ 891 893 W3025453843.pdf 5 8 bibliography 0.99791104 "Unger ER, Lin JS, Brimmer DJ, Lapp CW, Komaroff AL, Nath A, Laird S, Iskander J (2016). CDC grand rounds:chronic fatigue syndrome- advancing research and clinical education. MMWR Morbidity and Mortality Weekly Report 65(50 –51), 1434 –1438." 893 1140 W3025453843.pdf 5 9 separator 0.9833007 ¶ 1140 1142 W3025453843.pdf 5 10 bibliography 0.99703765 "Van den Heuvel L, Chishinga N, Kinyanda E ,et al. (2013). Frequency and correlates of anxiety and mood disorderamong TB- and HIV-infected Zambians. AIDS Care 25, 12; 1527 –1535." 1142 1324 W3025453843.pdf 5 11 separator 0.97815025 ¶ 1324 1326 W3025453843.pdf 5 12 bibliography 0.9978988 "Vollmer-Conna U (2001). Acute sickness behavior: an immune system to brain communication. Psychological Medicine 31, 761 –767." 1326 1457 W3025453843.pdf 5 13 separator 0.97726476 ¶ 1457 1459 W3025453843.pdf 5 14 bibliography 0.9978688 "Wang X, Zhang L, Lei Y ,et al. (2015). Meta-analysis of infectious agents and depression. Scientific Reports 4, 4530. doi:10.1038/srep04530 ." 1459 1605 W3025453843.pdf 5 15 separator 0.97587407 ¶ 1605 1607 W3025453843.pdf 5 16 bibliography 0.9980673 "Wojcik W, Armstrong D, Kanaan R (2011). Chronic fatigue syndrome: labels, meanings and consequences. Journal of Psychosomatic Research 70(6), 500 –504." 1607 1763 W3025453843.pdf 5 17 separator 0.9791682 ¶ 1763 1765 W3025453843.pdf 5 18 bibliography 0.9980398 "Xu J, Zhong S, Liu J ,et al. (2005). Detection of severe acute respiratory syndrome corona virus in the brain: potential role of chemokine migration in pathogenesis. Clinical Infectious Diseases 41, 1089 –1096.300 D. Lyons et al." 1765 2001 W3025453843.pdf 5 19 separator 0.8958546 ¶ 2001 2003 W3025453843.pdf 5 20 bibliography 0.976865 https://doi.org/10.1017/ipm.2020.40 Published online by Cambridge University Press 2003 2087 W3025453843.pdf 5 0 text 0.99836946 "to the size of the obese cohort, data for these women were combined into one group rather than being analysed separate- ly obese, severely obese and morbidly obese women." 0 174 W2920071635.pdf 6 1 separator 0.96229565 ¶ 174 176 W2920071635.pdf 6 2 text 0.99912614 "Morbidly obese women, in particular, present a different set of surgical and anaesthetic challenges to obese and severely obese women, meaning conclusions from this study should be extrapolated to morbidly obese women with caution." 176 414 W2920071635.pdf 6 3 separator 0.9353116 ¶ 414 416 W2920071635.pdf 6 4 text 0.9993814 "Although the three groups had similar baseline charac- teristics, the obese cohort was more likely to have a stage 3–4 apical POP on preoperative POP-Q. This may reflect that obese women with stage 2 vault POP were less likely to opt for surgery or an abdominal approach, or that in this cohort, they presented with a greater degree of POP than women who were overweight or of normal BMI." 416 817 W2920071635.pdf 6 5 separator 0.93896204 ¶ 817 819 W2920071635.pdf 6 6 text 0.9994538 "Preoperative POP stage 3 or 4 is a risk factor for recur- rence, and this bias could have affected subjective and objective cure rates in the obese group, although our anal- ysis would suggest this was not the case [ 3,18]." 819 1049 W2920071635.pdf 6 7 separator 0.9970261 ¶ 1049 1051 W2920071635.pdf 6 8 title 0.98970073 Interpretation 1051 1066 W2920071635.pdf 6 9 separator 0.9934666 ¶ 1066 1068 W2920071635.pdf 6 10 text 0.99945176 "This study demonstrates LSC is equally effective and with a comparable safety profile for normal weight, overweight and obese women when performed by a trained laparoscopic urogynaecologist. Data show a trend towards increased oper- ating time in normal weight women. One possible explanation is that surgeons are more likely to undertake complex cases, such as those with dense adhesions or previous urostomy, in women of normal BMI. An alternative explanation is that surgeons may prefer teaching trainee surgeons whilst operat- ing on women of normal BMI, which in turn may lead to longer operating times. This could also be a reflection of the small sample size." 1068 1757 W2920071635.pdf 6 11 separator 0.9966314 ¶ 1757 1759 W2920071635.pdf 6 12 title 0.99103 Generalisability 1759 1776 W2920071635.pdf 6 13 separator 0.9949932 ¶ 1776 1778 W2920071635.pdf 6 14 text 0.9965309 "All operations were performed in a tertiary unit by subspecial- ist urogynaecologists trained in laparoscopic urogynaecology. LSC can be technically challenging and requires an experi- enced laparoscopic surgeon to perform, particularly in over- weight and obese women due to difficulty accessing the sacral promontory. This is because the sacral promontory may be more difficult to identify and dissect in overweight and obese women, increasing the risk of a major vascular injury. Another difficulty performing LSC in obese women is in maintaining adequate ventilation while generating sufficient abdominal pressure to perform the procedure. We found this is easier when working with anaesthetists with bariatric experience." 1778 2527 W2920071635.pdf 6 15 separator 0.5368935 ¶ 2527 2529 W2920071635.pdf 6 16 text 0.9931277 "Our findings may not be generalisable to smaller units that do not have the equipment or personnel for managing obese women undergoing laparoscopy.Overall" 2529 2688 W2920071635.pdf 6 17 separator 0.9806542 ¶ 2688 2690 W2920071635.pdf 6 18 text 0.99934965 "Findings from this study are important, particularly in the context of the expanding obesity epidemic. Our data supports offering LSC to obese women with vault prolapse. It is our practice to offer both a LSC and a non-mesh alternative in the form of a vaginal sacrospinous fixation to all suitable women presenting with vault prolapse who wish to have surgical man- agement as part of a patient-centred, nondirective approach to care." 2690 3140 W2920071635.pdf 6 19 separator 0.99447846 ¶ 3140 3142 W2920071635.pdf 6 20 text 0.98161644 "Funding Coloplast provided funding to support data collection of the primary study (not published) and provision of the light-weight mesh but had no involvement in the design, analysis or conclusions of this second- ary study." 3142 3375 W2920071635.pdf 6 21 separator 0.9964352 ¶ 3375 3377 W2920071635.pdf 6 22 title 0.9931229 Compliance with ethical standards 3377 3411 W2920071635.pdf 6 23 separator 0.9940212 ¶ 3411 3413 W2920071635.pdf 6 24 text 0.9987091 "The findings of this study were presented at the British Society of Urogynaecology annual research meeting. None of the authors have any competing interests in the study." 3413 3588 W2920071635.pdf 6 25 separator 0.9882179 ¶ 3588 3590 W2920071635.pdf 6 26 title 0.95072764 Ethical approval 3590 3607 W2920071635.pdf 6 27 text 0.99864054 "All procedures performed in studies involving human participants were in accordance with the ethical standards of the institu- tional research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards." 3607 3866 W2920071635.pdf 6 28 separator 0.99513346 ¶ 3866 3868 W2920071635.pdf 6 29 title 0.9891834 Conflicts of interest 3868 3890 W2920071635.pdf 6 30 text 0.9985337 "C. Mahoney has received research grants from the National Institute of Health Research UK (NIHR) and is a member of the technical team for the National Institute for Health and Clinical Excellence (NICE) Clinical Guidelines on Urinary Incontinence and Pelvic Organ Prolapse. G. Scott declares no conflicts of interest. L. Dwyer has received research funding from Bulkamid. F. Reid has received research funding for an unrestricted industry funded investigator led study of stress urinary in- continence from Contura, was chief i nvestigator for a human tissue author- ity funded randomised controlled study of prolapse (PROSPECT) and is a member of Specialised National Health Service (NHS) commissioning committee for women's health. K. Ward is topic lead of the NICE Clinical Guideline on Urinary Incont inence Update. A. Smith has previous- ly received a research grant from Co loplast, which funded the primary study. R. Kearney is topic lead of the NICE Clinical Guideline on Pelvic Organ Prolapse Update and chief investigator of the Treatment of Prolapse with Self-care Pessary Study." 3890 5012 W2920071635.pdf 6 31 separator 0.97052056 ¶ 5012 5014 W2920071635.pdf 6 32 paratext 0.8556271 "Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http:// creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appro- priate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Publisher ’sn o t e Springer Nature remains neutral with regard to jurisdic- tional claims in published maps and institutional affiliations." 5014 5577 W2920071635.pdf 6 33 separator 0.9918772 ¶ 5577 5579 W2920071635.pdf 6 34 title 0.84656787 References 5579 5590 W2920071635.pdf 6 35 separator 0.98999363 ¶ 5590 5592 W2920071635.pdf 6 36 bibliography 0.9948589 "1. Marchionni M, Bracco G, Checcucci V , Carabaneanu A, Coccia E, Mecacci F, et al. True incidence of vaginal vault prolapse. Thirteen years of experience. J Reprod Med. 1999;44(8):679 –84.Int Urogynecol J (2019) 30:2041 –2048 2047" 5592 5828 W2920071635.pdf 6 0 paratext 0.9754189 "Research ArticleGlobal Dermatology ISSN: 2056-7863 Glob Dermatol, 2014 doi: 10.15761/GOD.1000116 Volume 1(2): 47-50" 0 132 W4231148076.pdf 0 1 title 0.94195265 "The efficacy and safety of Er:YAG laser for treatment of atrophic acne scars" 132 211 W4231148076.pdf 0 2 separator 0.97325873 ¶ 211 213 W4231148076.pdf 0 3 contact 0.98359895 "Mohamad Goldust* and Ramin Raghifar General Practitioner, Tabriz Azad University of Medical Sciences, Tabriz, Iran" 213 330 W4231148076.pdf 0 4 separator 0.99275434 ¶ 330 332 W4231148076.pdf 0 5 title 0.92022353 Abstract 332 341 W4231148076.pdf 0 6 separator 0.9926282 ¶ 341 343 W4231148076.pdf 0 7 text 0.99809724 "Objective: The efficacy of fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser is well substantiated. This study aimed at comparing the efficacy and safety of Er:YAG laser for treatment of atrophic acne scars." 343 567 W4231148076.pdf 0 8 separator 0.8814206 ¶ 567 569 W4231148076.pdf 0 9 text 0.99928683 "Methods: In this cross sectional study, 150 patients received four treatment sessions with Er:YAG fractional laser at 1-month interval. The laser parameters were kept constant for each of the four sittings in all patients. Qualitative and quantitative assessments were done using Goodman and Barron grading. Subjective assessment in percentage of improvement was also documented 1 month after each session. Photographs were taken before each treatment session and 1 month after the final session." 569 1072 W4231148076.pdf 0 10 separator 0.93629277 ¶ 1073 1075 W4231148076.pdf 0 11 text 0.9994502 "Results: Most patients showed at least fair improvement. Rolling and superficial box scars showed higher significant improvement when compared with ice pick and deep box scars. Patient’s satisfaction of improvement was higher when compared to physician’s observations. No serious adverse effects were noted with exacerbation of acne lesions forming the majority." 1075 1444 W4231148076.pdf 0 12 separator 0.7980211 ¶ 1445 1447 W4231148076.pdf 0 13 text 0.9995019 Conclusion: Er:YAG laser skin resurfacing was found to be a safe and effective treatment modality for treatment of atrophic acne scars. 1447 1583 W4231148076.pdf 0 14 separator 0.9970385 ¶ 1583 1585 W4231148076.pdf 0 15 title 0.912919 Introduction 1585 1598 W4231148076.pdf 0 16 separator 0.9951978 ¶ 1598 1600 W4231148076.pdf 0 17 text 0.999462 "Acne scars are the most common causes of facial scarring. Because the cosmetic discomfort is important for patients, therapeutic approaches seem to be precious and indispensable. Laser skin resurfacing has become a popular treatment modality for patients with atrophic acne scars [1,2]. Years after outgrowing acne, the aftermath of acne scars persists. Advances in acne therapy and dermatologic surgery have made it unnecessary for acne patients, both current and past to endure acne scarring [3,4]. For the lucky majority, acne scarring is a minor annoyance, obvious to the one affected yet difficult for others to see. For some, however, acne scarring can cause devastating long-term emotional suffering [5,6]. Teens may deal with depression, become withdrawn and lose self-confidence. Because 95% of acne patients will develop scarring to some degree, the earlier the treatment appropriate for the severity of the outbreak is initiated, the better the odds are that scar formation will be mild [7,8]. Delaying acne therapy by 3 or more years is likely to increase one’s risk of more significant acne scarring. Newer acne therapies make it needless for anyone to suffer from severe acne or develop scarring [9,10]. Early medical intervention is key to preventing unnecessary disfigurement. While this doesn’t mean that everyone suffering a solitary blemish or minor premenstrual flare-up should rush to schedule an appointment with a dermatologist [11,12]. Many therapeutic measures such as chemical peeling, subcision, dermabrasion, fillers, and punch techniques have been performed to improve acne scarring but with suboptimal outcomes [13,14]. Although significant clinical improvements can be seen with ablative lasers, adverse effects such as prolonged post-procedure erythema and dyspigmentation impede their widespread use especially in patients with darker skin [15,16]. Erbium: yttrium–aluminum–garnet (Er:YAG) laser treatment was approved for cutaneous laser resurfacing by the US Food and Drug Administration in 1996 [4,5]. Once the surface skin is ablated layer by layer, the skin regenerates with increased collagen production [17,18]. The aim of this study was to compare the efficacy and safety of Er:YAG laser for treatment of atrophic acne scars." 1600 3873 W4231148076.pdf 0 18 separator 0.9972913 ¶ 3873 3875 W4231148076.pdf 0 19 title 0.9888858 Methods 3875 3883 W4231148076.pdf 0 20 separator 0.99518406 ¶ 3883 3885 W4231148076.pdf 0 21 text 0.9996176 "This cross sectional study was designed using fractional laser resurfacing for the treatment of atrophic facial acne scars in 150 patients in Tabriz special clinic from April 2011 to April 2014. This study was approved by local ethic committee. Written consent was obtained from all the patients. Patients diagnosed with atrophic acne scarring aged 18 years or above were included. Exclusion criteria were patients with infectious diseases (hepatitis B and C, HIV), history of mkeloids or hypertrophic scarring, photosensitivity, unrealistic expectation of the patient and facial laser resurfacing, chemical peels, fillers, or botulinum toxin injection or usage of oral retinoids within the last 6 months. No regimen was prescribed prior to laser therapy. For the anesthesia, topical EMLA cream (Astra Zeneca, UK) was used prior to each laser procedure. After 30 minutes, the topical anesthetic was removed. Eyes were protected with eye shields. All 150 patients received four sittings of laser treatment at 1-month interval. They were treated with fractional ablative resurfacing module using 2940 nm Er:YAG" 3885 4997 W4231148076.pdf 0 22 separator 0.9898881 ¶ 4998 5000 W4231148076.pdf 0 23 contact 0.9959533 "Correspondence to: Mohamad Goldust, General Practitioner, Tabriz Azad University of Medical Sciences, Tabriz, Iran, Tel: 00989111289630, Fax: 00984113368805; E-mail: Drmgoldust@yahoo.com" 5000 5190 W4231148076.pdf 0 24 separator 0.9875934 ¶ 5191 5193 W4231148076.pdf 0 25 paratext 0.9125826 "Key words: atrophic acne scars, Er:YAG laser, treatmentReceived: November 18, 2014; Accepted: December 20, 2014; Published: December 22, 2014" 5193 5338 W4231148076.pdf 0 0 paratext 0.9406585 133 0 3 W2542694118.pdf 4 1 title 0.72828966 GOSPODARKA OPARTA NA WIEDZY JAKO DETERMINANTA KONWERGENCJI GOSPODARCZE 3 74 W2542694118.pdf 4 2 paratext 0.5868193 J... 74 76 W2542694118.pdf 4 3 separator 0.9886552 ¶ 76 78 W2542694118.pdf 4 4 text 0.8624573 "rozwojowej, może być wzrost efektywności pracy. Teza ta znajduje potwierdzenie w literaturze przedmiotu [Dobrinsky, Havlik, 2014, s. 21; Gärtner, 2003, s. 271]." 78 242 W2542694118.pdf 4 5 separator 0.98142403 ¶ 243 245 W2542694118.pdf 4 6 text 0.99891853 "Doświadczenia krajów zrzeszonych w Organizacji Współpracy Gospodarczej i Roz- woju (OECD) wskazują, że struktura czynników produkcji ulega obecnie poważnej zmianie. Malejący udział niskokwalifikowanej siły roboczej i kapitału fizycznego w tworzeniu PKB jest kompensowany przez wzrost udziału technologii, kapita - łu ludzkiego i kapitału społecznego [Marciniak, 2009, s. 369]. Przewaga postępu technicznego jako czynnika wzrostu wynika również z faktu, że usprawnienia o cha- rakterze technicznym w sposób trwały wpływają na długookresową stopę wzrostu, natomiast skutki ekonomiczne wzrostu stopy inwestycji zanikają po osiągnięciu nowego stanu ustalonego [Kubielas, 2009, s. 228]." 245 945 W2542694118.pdf 4 7 separator 0.99735296 ¶ 945 947 W2542694118.pdf 4 8 title 0.9941015 4. Gospodarka oparta na wiedzy w Polsce 947 987 W2542694118.pdf 4 9 separator 0.99648 ¶ 987 989 W2542694118.pdf 4 10 title 0.9860858 4.1. Definicja pojęcia 989 1012 W2542694118.pdf 4 11 separator 0.99253213 ¶ 1012 1014 W2542694118.pdf 4 12 text 0.9992573 "Zgodnie z definicją przyjętą przez OECD i Bank Światowy pojęcie „gospodarka oparta na wiedzy” oznacza model gospodarki, w którym [...] wiedza jest tworzona, pozyskiwana, przekazywana i wykorzystywana efektywnie przez przedsiębiorstwa, organizacje, jednostki i społeczności. Nie jest ograniczona do przemysłów zaawansowanych technologii lub technologii informacyjno-telekomunikacyjnych, ale stanowi podstawę analiz politycznych w dziedzinie edukacji, infrastruktury informacyjnej i systemów innowacji, które mogą sprzyjać wprowadzaniu GOW [Dahlman, Anderson, 2000, s. 3]." 1014 1604 W2542694118.pdf 4 13 separator 0.97599983 ¶ 1604 1606 W2542694118.pdf 4 14 text 0.99442655 "Ze względu na odnotowane w literaturze przedmiotu różnice w podejściu meto - dologicznym do pomiaru zaawansowania GOW [Piech, 2006, s. 232; Skrzypek, 2009, s. 83–85] i wielość ujęć definicyjnych tego pojęcia [Bojewska, 2015, s. 25; Dworak, 2014, s. 13; Żelazny, 2015, s. 47] ocena stanu zaawansowania GOW w konkretnym przypadku jest uzależniona od przyjętej definicji tego pojęcia i doboru danych źró - dłowych [Dworak, 2014, s. 11–14]." 1606 2056 W2542694118.pdf 4 15 separator 0.97254515 ¶ 2056 2058 W2542694118.pdf 4 16 text 0.99829894 "Powszechnie stosowana do pomiaru zaawansowania kraju pod względem GOW jest metodologia Banku Światowego KAM (Knowledge Assessment Methodology) [World Bank, 2012; Strożek, 2012, s. 106–110]. Umożliwia ona obliczenie dla po - szczególnych obszarów geograficznych syntetycznego wskaźnika zaawansowania poziomu gospodarki opartej na wiedzy KEI (Knowledge Economy Index), który opiera się na takich filarach, jak:" 2058 2480 W2542694118.pdf 4 17 separator 0.8908762 ¶ 2480 2482 W2542694118.pdf 4 18 text 0.6415549 1. Bodźce ekonomiczne i otoczenie instytucjonalne. 2482 2533 W2542694118.pdf 4 19 table 0.4410044 ¶ 2533 2535 W2542694118.pdf 4 20 text 0.45247424 2. Innowacje 2535 2548 W2542694118.pdf 4 21 table 0.40635768 2548 2549 W2542694118.pdf 4 22 text 0.5275968 i adaptacja technologiczna. 2549 2576 W2542694118.pdf 4 23 table 0.41451985 ¶ 2576 2578 W2542694118.pdf 4 24 text 0.52370274 3. Edukacja i szkolenia. 2578 2603 W2542694118.pdf 4 25 separator 0.47223562 ¶ 2603 2605 W2542694118.pdf 4 26 text 0.4033059 4. Infrastruktura 2605 2623 W2542694118.pdf 4 27 table 0.42239514 informacyjno-telekomunikacyjna. 2623 2655 W2542694118.pdf 4 28 bibliography 0.5662002 Pobrane z czasopisma Annales H - Oeconomia http://oeconomia.annales.umcs.pl 2655 2730 W2542694118.pdf 4 29 separator 0.97962 ¶ 2730 2732 W2542694118.pdf 4 30 paratext 0.95164955 Data: 18/05/2024 03:36:12 2732 2758 W2542694118.pdf 4 0 paratext 0.9892988 Page 9 of 11 0 12 W4206908695.pdf 8 1 separator 0.92686975 ¶ 12 14 W4206908695.pdf 8 2 paratext 0.55539536 Signer‐Hasler et al. 15 36 W4206908695.pdf 8 3 title 0.4955675 Genetic 36 44 W4206908695.pdf 8 4 paratext 0.6501605 s Selection Evolution (2022) 54:6 44 88 W4206908695.pdf 8 5 separator 0.9755721 ¶ ¶ 89 95 W4206908695.pdf 8 6 text 0.9993242 "from a lineage close to the West Caucasian tur and is linked to pathogen resistance. In line with this study, we report a ROH island that harbors MUC6 (Table 4) and (see Additional file 1: Table S3). However, we cannot con - firm the fixation of the haplotype in the 10 modern goat populations investigated here (results not shown)." 95 445 W4206908695.pdf 8 7 separator 0.92294246 ¶ 445 447 W4206908695.pdf 8 8 text 0.9995943 "In addition to the signature of selection containing MUC6 , Zheng et al. [34] located the strongest signature of selection on chromosome 15 that harbors the STIM1 and RRM1 genes. STIM1 was previously presented as a specific signature of directional selection in domes - tic goats [26]. In our data, the region on chromosome 15 (32,098,192–32,367,622 bp) that contains the RHOG , STIM1 and RRM1 genes was one among the 15 com - mon ROH islands in the 217 individuals from the 10 modern breeds (Fig. 3, Table 3) and (see Additional file 1: Tables S2 and S3). Whether the reduced genetic diversity in modern breeds is the result of selection on behavio - ral advantages [3, 34], improvement of meat quantity [26] or other phenotypes is not yet clear. The underlying causative variant(s) of this signature of selection and the selected phenotype(s) need to be investigated in future studies." 447 1387 W4206908695.pdf 8 9 separator 0.97205895 ¶ 1387 1389 W4206908695.pdf 8 10 text 0.9996875 "We present a more detailed analysis of the eight genes that are in ROH islands (Table 3). Two of these genes, STC1 and SLC9A3 showed the highest differentiation between BEZ and modern goat breeds (see Additional file 1: Table S3). In all the modern breeds, the fraction of individuals that carry these genes in a ROH is ubiqui - tously high, while the corresponding proportions in BEZ are remarkably lower (Tables 3 and 4) and (see Additional file 1: Tables S2 and S3). Both of these genes harbor vari - ants that nearly reached fixation in the modern breeds." 1389 1978 W4206908695.pdf 8 11 separator 0.9417357 ¶ 1979 1981 W4206908695.pdf 8 12 text 0.9996899 "Interestingly, SLC9A3 was previously detected in a signa - ture of selection by comparing WGS data from 24 BEZ and 164 domestic modern goats [34]. We speculate that these genes played an important role during differentia - tion between the wild Bezoar and modern goat breeds and consequently, they could represent new domestica - tion genes." 1981 2338 W4206908695.pdf 8 13 separator 0.9959005 ¶ 2338 2340 W4206908695.pdf 8 14 title 0.9923186 Protein coding variants in the STC1 and TSHR genes 2340 2391 W4206908695.pdf 8 15 separator 0.9938974 ¶ 2391 2393 W4206908695.pdf 8 16 text 0.9997454 "Detailed inspection of the STC1 gene revealed a mis - sense variant (p.Lys139Arg). Modern European goats are nearly fixed for the derived allele, while Bezoar goats are completely fixed for the reference allele (Fig. 4). The data from the VarGoats consortium confirmed the absence of the alternate allele in wild goats (N = 44) and its high frequency in modern European goats (0.90; N = 282) (see Additional file 1: Table S5). The STC1 gene encodes stanniocalcin-1, a glycoprotein that is involved in differ - ent biological processes including angiogenesis, bone and muscle development, and cellular metabolism [35]. Jellinek et al. [36] proposed, that STC1 and STC2 play a role in calcium and phosphate homoeostasis. Based on immunocytochemistry analysis, it was concluded that the stanniocalcin-1 protein is involved in muscle and bone development of the mouse fetus [37]. The STC2 gene was suggested to explain size reduction in dogs [28, 38]. Rah - malla et al. [39] showed that the Taggar goat breed, which is an achondroplastic dwarf goat breed, was strongly dif - ferentiated from other Sudanese goat breeds at 208 genes including STC1 . In dairy cattle, STC1 was proposed to be involved in the lactation process and the control of involution of milk-producing tissue [40]. Unfortu - nately, information describing phenotypic differences between modern goat breeds and wild Bezoar goats is sparse (Table 1) but it is assumed, that the domestication of goats led to a reduction in body size and horns [41] and that milk yield increased [42]. We speculate that the STC1 :p.Lys139Arg variant may contribute to differences in body size or milk yield between modern goat breeds and wild Bezoar goats. The exact functional role of this variant needs to be validated in future studies." 2393 4274 W4206908695.pdf 8 17 separator 0.9875368 ¶ 4274 4276 W4206908695.pdf 8 18 text 0.99973434 "The ROH island that contains the TSHR gene and the TSHR :p.Ala239Thr variant raised our interest. A variant in the TSHR gene was previously shown to cause reduced seasonality of reproduction in domestic chicken com - pared to its wild ancestor, the jungle fowl [29]. In sheep, TSHR was highlighted in an ancestral signature of selec - tion by Fariello et al. [43] and the authors concluded, that sheep raised in temperate climates experience a reproductive cycle under photoperiodic control. All the modern goat breeds investigated here have a seasonal reproductive cycle starting in late August with decreas - ing day length, followed by a birth season from January till March after 150 days of gestation. In contrast, for wild Bezoar goats, rut is described to last from Novem - ber until February [44, 45]. Including the information from the VarGoats consortium, we found that the fre - quencies for the derived 239Thr allele were close to 80% in the European goat breeds, while the frequencies were lower than 20% for goats sampled in tropical regions such as Africa, Asia, Oceania and America (see Additional file 1: Table S5). Goats bred in tropical and equatorial regions are subject to less variation in photoperiod and temperature. They display a longer breeding season than those bred in temperate and polar regions, which exhibit more pronounced seasonal effects [46]. As a promi - nent example, the Boer goat originating from Africa has a non-seasonal reproductive cycle [47, 48]. Only five of the 37 sequences from the Boer individuals collected by the VarGoats consortium carried the alternate allele in a heterozygous state, while the remaining 32 goats were homozygous for the reference allele (see Additional file 1: Table S5). In previous studies, SOX14, NOCT, RAI1, TH" 4276 6158 W4206908695.pdf 8 0 text 0.99796915 "e 0,7 cm de largura basal. Em câmara asséptica, foi realizado corte da parte aérea l ,0 cm acima do rizoma com o auxílio de pinça e bisturi flambados, retiran- do-se possíveis raízes." 0 189 W1974735456.pdf 2 1 separator 0.9538586 ¶ 189 191 W1974735456.pdf 2 2 text 0.99920684 "Os explantes foram inoculados em meio de cultura M1, isento de fítoreguladores, com as di- versas concentrações de BAR Foram a seguir leva- dos para sala de crescimento. O delineamento ado- tado foi o inteiramente casualizado e a avaliação foi realizada através do peso e do número de brotos emitidos após 45 dias." 191 518 W1974735456.pdf 2 3 separator 0.968448 ¶ 518 520 W1974735456.pdf 2 4 text 0.99958354 "Uma vez que existem autores que recomen- dam a utilização de reguladores de crescimento (auxinas) para a indução do enraizamento em Musa e outros que dispensam a sua utilização, realizou-se experimento para a determinação dos melhores reguladores de crescimento e concentrações adequa- das a serem utilizados para o enraizamento de plântulas de bananeira ""Maçã"". Para tanto, foram usadas 130 plântulas, com aproximadamente 3,5 cm de altura, originadas do cultivo in vitro e que ainda não estavam enraizadas." 520 1048 W1974735456.pdf 2 5 separator 0.9570608 ¶ 1048 1050 W1974735456.pdf 2 6 text 0.9996591 "Os reguladores de crescimento testados fo- ram as auxinas AIA, AIB e ANA, sendo que asplântulas foram inoculadas individualmente em tu- bos de ensaio contendo 25 ml de meio Ml, sem a presença de citocininas, com as auxinas citadas nas concentrações de 0; 0,1; 0,5; 1,0 e 5,0 mg.l-1 e 1,5 g.1-1 de gel (phytagel-Sigma) e mantidas em sala de crescimento." 1050 1415 W1974735456.pdf 2 7 separator 0.8409634 ¶ 1415 1417 W1974735456.pdf 2 8 text 0.99933714 "O delineamento foi inteiramente casualizado com cinco tratamentos (doses) e 10 repetições (1 plântula por repetição). A avaliação foi feita através do número de raízes e comprimento do sistema radicular após 14 dias da inoculação." 1417 1656 W1974735456.pdf 2 9 separator 0.95610654 ¶ 1656 1658 W1974735456.pdf 2 10 text 0.99950534 "Após as plântulas atingirem 6-9 cm, fo- ram levadas para casa de vegetação, onde foram aclimatadas em sacos plásticos de 10 x 12 cm, con- tendo mistura autoclavada de terra argilosa, matéria orgânica e areia nas proporções de 1:1:1, respectiva- mente. As mudas foram colocadas dentro de câma- ra úmida durante 4 dias. Após este período, foram retiradas e mantidas dentro de casa de vegetação" 1658 2064 W1974735456.pdf 2 11 separator 0.8528638 ¶ 2064 2066 W1974735456.pdf 2 12 text 0.9989732 "As análises estatísticas foram realizadas através de análises de variância e foi utilizado o tes- te de Tukey para os dados de contagem transformados segundo e através de equações de regres- são, quando necessário." 2066 2289 W1974735456.pdf 2 13 separator 0.9911039 ¶ 2289 2291 W1974735456.pdf 2 14 title 0.99253374 RESULTADOS E DISCUSSÃO 2291 2314 W1974735456.pdf 2 15 separator 0.99555075 ¶ 2314 2316 W1974735456.pdf 2 16 text 0.9996922 "Os ápices caulinares inoculados, que a princípio possuíam a coloração creme, adquiriram a coloração verde após uma semana, CRONAUER & KRIKORIAN (1984) também observaram estas al- terações, porém, no presente trabalho, os explantes apresentaram leve escurescimento devido a oxida- ção superficial dos mesmos, a qual, não chegou a prejudicar o seu desenvolvimento." 2316 2693 W1974735456.pdf 2 17 separator 0.89261806 ¶ 2693 2695 W1974735456.pdf 2 18 text 0.9996541 "Durante os primeiros vinte dias ocorreu entumescimento dos explantes, que cresceram diametralmente. Após 25-35 dias de cultivo inicia- ram-se as brotações que atingiram em média 5-6 brotos por explante em 45 dias de cultivo.Com relação à capacidade de brotação de ápices caulinares extraídos de diferentes maneiras, após um mês, os resultados podem ser vistos na TABELA l. Em alguns casos, houve tendência para a formação de plântulas únicas, sem brotações late- rais, isto ocorreu em alguns explantes pertencentes ao tipo 2. O tratamento que diferiu estatisticamente, apresentando o maior número médio de brotos foi o de número 3, isto é, os ápices caulinares que sofre- ram a retirada das bainhas foliares e que continham o ápice caulinar apical mais as gemas laterais." 2695 3495 W1974735456.pdf 2 19 separator 0.97967356 ¶ 3495 3497 W1974735456.pdf 2 20 text 0.9991953 "NOVAK et al. (1987) utilizaram explantes que correspondem ao tipo 5 com a finalidade de indução de mutações. No presente trabalho, este explante apresentou tendência para menor média" 3497 3686 W1974735456.pdf 2 21 separator 0.98393404 ¶ 3686 3688 W1974735456.pdf 2 0 separator 0.52243435 ¶ 1 2 W4299509952.pdf 2 1 paratext 0.8489159 "¶ Comparison of Extral evator Abdominoperineal Excision (ELAPE)and Abdominal - Perineal Resection (APR) ¶ http://www.ijSciences.com V olume 5 – March 2016 (03)" 4 206 W4299509952.pdf 2 2 separator 0.98848224 ¶ 208 210 W4299509952.pdf 2 3 text 0.9992496 "109 prospective multicentric study of ELAPE[11]. There are 102 patients of postoperative of ELAPE in this study. The median intraoperative blood loss was 200mL. There are 6 cases with positive of CRM (5.9 %), there are 4 cases with IOP(3.9%), local recurrence rate was 4.9%. Whether single -center or multicentric study confirmed ELAPE has a lower rate of IOP and positive rate of CRM and local recurrence rate than traditional APR." 210 668 W4299509952.pdf 2 4 separator 0.9884543 ¶ ¶ 670 676 W4299509952.pdf 2 5 title 0.99129224 4. Operative time and blood loss volume 676 716 W4299509952.pdf 2 6 separator 0.98484194 ¶ 718 720 W4299509952.pdf 2 7 text 0.9997664 "ELAPE needs changing position, while APR su rgery without changing position, ELAPE and APR have a roughly the same time during the surgery of abdominal and perineal region, therefore the operative time of ELAPE was significantly longer than the APR. The surgical field of ELAPE more in the gap betwee n advances, the gap between relatively small amount of bleeding. The surgical fields of ELAPE between the gap and less hemorrhage volume between the gap." 720 1200 W4299509952.pdf 2 8 separator 0.96945393 ¶ ¶ 1202 1208 W4299509952.pdf 2 9 title 0.9900136 5. Postoperative quality of life 1208 1241 W4299509952.pdf 2 10 separator 0.9877575 ¶ 1243 1245 W4299509952.pdf 2 11 text 0.99974984 "Angenete et al [12] compared clinical data from 2004 to 2009,it contains 31 cases of traditional APR and 38 cases ELAPE. During a mean follow -up of 44 months , stoma necrosis were more common for ELAPE (34% VS10%), but it is common that stome bandaging problem and low stoma height for traditional APR. The patients wer e followed up for one year, two groups have no significant difference of stoma function. Welsch et al [13] retrospectively analyzed 30 patients from 2007 to 2011 and accept ELAPE, it is the similar for traditional APR at the quality of life score and they think that the ELAPE did not reduce the overall quality of life scores. But ELAPE have a higher incidence of complication of perineal especially the perineal pain (50%) and affect the postoperative urinary reproductive function.It is pointed out that it ne ed to improve the technology in order to reduce complications. Vaughan -Shaw et al. [14] compared APR and ELAPE in the quality of life,it includes 16 cases of ELAPE and 20 cases of APR and evaluate the quality of life of the patients who after two weeks sur gery use EORTC 、QLQ -C30 and QLQ -C29 questionnaires. They found that it is no significant difference in the quality of life and short -term prognosis of the two groups of patients. From the current study, the overall quality of life in patients after ELAPE ha s no significant difference with the traditional APR, but the incidence of postoperative perineal chronic pain may increase." 1245 2805 W4299509952.pdf 2 12 separator 0.9210417 ¶ ¶ 2807 2813 W4299509952.pdf 2 13 text 0.99959576 "ELAPE surgery removes more tissue around the rectum, forming a huge defect of pelvic floor . It may increase the chance of pelvic and perineal nerve damage, especially the pelvic plexus, the pudendal nerve, the penis / clitoris dorsal nerve and the pelvic neurovascular bundle and it may increase the incidence of postoperative complications what the sexual dysfunction and urinary rete ntion .[15] Recent European multi -center study point out that in addition to the perineal wound complications and the pelvic complications of ELAPE is two times that of traditional APR, mainly composed of sexual function and urination disorders .[16]The l aparoscopic ELAPE study also found that after the QLQ -CR29 questionnaire survey , male patients have significant erectile dysfunction (average 75 points ), they comprehensive analysis of all patients and found that the frequency of urination has a moderate ly increase (average 37.5 points ).[17]" 2813 3824 W4299509952.pdf 2 14 separator 0.9861271 ¶ ¶ 3826 3832 W4299509952.pdf 2 15 title 0.9897945 "6. Surgical wound infection and surgical incision reoperation rate" 3832 3902 W4299509952.pdf 2 16 separator 0.9783933 ¶ 3904 3906 W4299509952.pdf 2 17 text 0.9996729 "In 2012 a single -center retrospective study in Sweden compered two cases of ELAPE and APR in quality of resection specimens and postoperative complica tions .[18] The two groups were comparable in operative indications and the TNM stage of preoperative . The study shows that ELAPE and APR have no statistical significance in the positive rate of CRM (17% vs.20%) and the rate of IOP(13% vs.10%)" 3906 4331 W4299509952.pdf 2 0 paratext 0.98547876 Revista da Faculdade de Serviço Social da Universidade do Estado do Rio de Janeiro 366 0 86 W2790066768.pdf 0 1 separator 0.9708967 ¶ 86 88 W2790066768.pdf 0 2 title 0.991635 R E S E N H A 88 102 W2790066768.pdf 0 3 separator 0.8069444 ¶ 102 104 W2790066768.pdf 0 4 title 0.95300865 "A experiência brasileira das fábricas recuperadas" 104 156 W2790066768.pdf 0 5 separator 0.9938969 ¶ 156 158 W2790066768.pdf 0 6 paratext 0.30584323 PIRES 158 164 W2790066768.pdf 0 7 contact 0.30194715 , A. S 164 170 W2790066768.pdf 0 8 bibliography 0.31263986 . 170 171 W2790066768.pdf 0 9 contact 0.28791234 S 171 173 W2790066768.pdf 0 10 bibliography 0.34027132 . 173 174 W2790066768.pdf 0 11 title 0.47984615 As fábricas recuperadas no Brasil : o desafio da autogestão 174 234 W2790066768.pdf 0 12 bibliography 0.26327756 . 234 235 W2790066768.pdf 0 13 separator 0.981129 ¶ 235 237 W2790066768.pdf 0 14 contact 0.57502407 São Carlos: EdUFSCcar, 2016. 237 266 W2790066768.pdf 0 15 separator 0.9183538 ¶ 266 268 W2790066768.pdf 0 16 contact 0.9755683 "Mariana Costa Carvalho* .............................................................................. * Mestre em Serviço Social pela Universidade Federal de Juiz de Fora (UFJF), doutoranda em Serviço Social pela Universidade do Estado do Rio de Janeiro (PPGSS/FSS/Uerj). Correspondência: Rua Engenheiro José Carlos Morais Sarmento, 259, apt. 201, Santa Catarina, Juiz de Fora - MG. CEP: 36036-100. Email: ." 268 721 W2790066768.pdf 0 17 text 0.97694856 "A obra, publicada em 2016, resulta de pesquisa de doutoramento em Sociologia, em 2014, na Universidade Federal de São Carlos. O livro,estruturado em 5 partes, apresenta os resultados de pesquisa de Aline SuelenPires que possui trajetória acadêmica na área de Sociologia do Trabalho. Oobjeto da pesquisa é a apresentação da situação atual das fábricas recupe-radas no Brasil, pensadas em articulação com a autogestão, cooperativismo, economia solidária e a percepção dos trabalhadores envolvidos." 721 1220 W2790066768.pdf 0 18 separator 0.9665582 ¶ 1220 1222 W2790066768.pdf 0 19 text 0.9936312 "A pesquisa abarcou visitas a nove empresas recuperadas no Brasil, com a realização de entrevistas e observações: Cooperminas, Bruscor,Coopermambrini, Coopersalto, Metalcoop, Copromem, Uniforja, Unimá-quinas e Flaskô. Além de visitas às principais instituições de apoio às fábricasrecuperadas, a ANTEAG (Associação Nacional de Trabalhadores e em Em-presas de Autogestão e Participação Acionária) e a UNISOL Brasil (Centralde Cooperativas e Empreendimentos Solidários)." 1222 1692 W2790066768.pdf 0 20 separator 0.9012513 ¶ 1692 1694 W2790066768.pdf 0 21 text 0.9969212 "Realiza um comparativo entre a experiência brasileira e argentina, traz uma breve apresentação das experiências de fábricas recuperadas deoutros países da América Latina e, ainda, notas sobre o cooperativismo e aeconomia solidária na Europa atual. Totalizando 12 visitas a empresas recu- peradas." 1694 1995 W2790066768.pdf 0 22 separator 0.99539226 ¶ 1995 1997 W2790066768.pdf 0 23 paratext 0.5843545 EM PAUTA 1997 2006 W2790066768.pdf 0 24 bibliography 0.5326048 , Rio de Janeiro 2006 2022 W2790066768.pdf 0 25 paratext 0.5381966 2022 2023 W2790066768.pdf 0 26 bibliography 0.5033456 _ 2023 2024 W2790066768.pdf 0 27 paratext 0.5292055 2 2024 2026 W2790066768.pdf 0 28 bibliography 0.54897976 o Semestre de 2026 2039 W2790066768.pdf 0 29 paratext 0.5125217 2017 2039 2044 W2790066768.pdf 0 30 bibliography 0.5758767 - n. 2044 2049 W2790066768.pdf 0 31 paratext 0.5428221 40 2049 2052 W2790066768.pdf 0 32 bibliography 0.5613162 , v. 2052 2056 W2790066768.pdf 0 33 paratext 0.56743824 15, p. 366 - 369 2056 2073 W2790066768.pdf 0 0 paratext 0.96704704 "1 Vol.:(0123456789) Scientific Reports | (2021) 11:17641 | https://doi.org/10.1038/s41598-021-96916-1 www.nature.com/scientificreportsAuthor" 0 153 W3197246832.pdf 0 1 title 0.88811207 "Correction: Identification, characterization and control of a sequence variant in monoclonal antibody drug product: a case study" 153 295 W3197246832.pdf 0 2 separator 0.99449193 ¶ 295 297 W3197246832.pdf 0 3 bibliography 0.99058515 "Anushikha Thakur , Rekha Nagpal, Avik Kumar Ghosh, Deepak Gadamshetty, Sirisha Nagapattinam, Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja Govindappa, Harish V. Pai & Ramakrishnan Melarkode Subbaraman" 297 534 W3197246832.pdf 0 4 separator 0.82598376 ¶ 535 537 W3197246832.pdf 0 5 paratext 0.8765154 Correction to: Scientific Reports https:// doi. org/ 10. 1038/ s41598- 021- 92338-1 , published online 24 June 2021 537 657 W3197246832.pdf 0 6 separator 0.9950639 ¶ 657 659 W3197246832.pdf 0 7 text 0.9750951 The Supplementary Information published with this Article contained errors. 659 735 W3197246832.pdf 0 8 separator 0.56927717 ¶ 735 737 W3197246832.pdf 0 9 text 0.9490632 "The order of authors was incorrectly given as Anushikha Thakur, Rekha Nagpal, Deepak Gadamshetty, Sirisha N., Malini Subbarao, Shreshtha Rakshit, Sneha Padiyar, Suma Sreenivas, Nagaraja G., Harish V Pai, Ramakrishnan M. S, Avik Kumar Ghosh. In addition, Affiliation 1 was incorrectly given as “Science and Technology Innovation Center (SnTIC), Biocon Biologics, Biocon Park, SEZ, Bommasandra Industrial Area, Jigani Link Road, Bangalore, India 560100. ”" 737 1202 W3197246832.pdf 0 10 separator 0.82424104 ¶ 1202 1204 W3197246832.pdf 0 11 text 0.9648864 "These errors have now been corrected in the Supplementary Information file that accompanies the original Article." 1204 1321 W3197246832.pdf 0 12 separator 0.9749286 ¶ 1321 1323 W3197246832.pdf 0 13 paratext 0.90506256 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/." 1323 2207 W3197246832.pdf 0 14 separator 0.7836628 ¶ 2207 2209 W3197246832.pdf 0 15 paratext 0.9662481 © The Author(s) 2021OPEN 2209 2234 W3197246832.pdf 0 16 separator 0.9937861 ¶ 2234 2236 W3197246832.pdf 0 0 text 0.9893011 any treatment for SLE, which is quite interesting. 0 50 W4281566253.pdf 9 1 separator 0.89288723 ¶ ¶ 52 58 W4281566253.pdf 9 2 text 0.9853127 Is the background of the case’s history and progression described in sufficient detail? 58 146 W4281566253.pdf 9 3 separator 0.68657017 ¶ 146 148 W4281566253.pdf 9 4 text 0.9649989 "Partly Are enough details provided of any physical examination and diagnostic tests, treatment given and outcomes? Partly Is sufficient discussion included of the importance of the findings and their relevance to future understanding of disease processes, diagnosis or treatment?" 148 440 W4281566253.pdf 9 5 separator 0.86524564 ¶ 440 442 W4281566253.pdf 9 6 text 0.95943415 "Yes Is the case presented with sufficient detail to be useful for other practitioners?" 442 531 W4281566253.pdf 9 7 separator 0.8202895 ¶ 531 533 W4281566253.pdf 9 8 text 0.7419373 No 533 536 W4281566253.pdf 9 9 separator 0.9733006 ¶ 536 538 W4281566253.pdf 9 10 text 0.6769038 Competing Interests: No competing interests were disclosed. 538 599 W4281566253.pdf 9 11 separator 0.9944867 ¶ 599 601 W4281566253.pdf 9 12 title 0.7901442 Reviewer Expertise: TTP, Hematology 601 638 W4281566253.pdf 9 13 separator 0.9813233 ¶ 638 640 W4281566253.pdf 9 14 text 0.97540194 "I confirm that I have read this submission and believe that I have an appropriate level of expertise to state that I do not consider it to be of an acceptable scientific standard, for reasons outlined above." 640 854 W4281566253.pdf 9 15 separator 0.9431963 ¶ 854 856 W4281566253.pdf 9 16 paratext 0.9532182 "Reviewer Report 15 November 2021 https://doi.org/10.5256/f1000research.54448.r97915 © 2021 Pavenski K. This is an open access peer review report distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited." 856 1211 W4281566253.pdf 9 17 separator 0.9395497 ¶ 1211 1213 W4281566253.pdf 9 18 contact 0.96363544 "Katerina Pavenski ¶ 1 Department of Medicine and Laboratory Medicine, St. Michael's Hospital - Unity Health Toronto, Toronto, Canada" 1213 1356 W4281566253.pdf 9 19 separator 0.6626326 ¶ 1358 1360 W4281566253.pdf 9 20 contact 0.9919171 "2 Department of Medicine and Laboratory Medicine, St. Michael's Hospital - Unity Health Toronto, Toronto, Canada" 1360 1476 W4281566253.pdf 9 21 separator 0.9917005 ¶ 1478 1480 W4281566253.pdf 9 22 text 0.9941946 "This is a case report of a 32yo female with a new diagnosis of presumably immune TTP. The case is not unique but still may have value to the readers with appropriate revisions. I summarize my feedback below:" 1480 1694 W4281566253.pdf 9 23 separator 0.9871493 ¶ ¶ 1696 1702 W4281566253.pdf 9 24 title 0.547721 Title 1702 1708 W4281566253.pdf 9 25 separator 0.97949797 ¶ 1710 1712 W4281566253.pdf 9 26 text 0.9966356 "Based on reading this case report, I am not convinced that your patient fulfils the diagnostic criteria for SLE. She clearly has positive autoimmune serology but does not appear to have any clinical features of SLE. Finding of positive autoimmune serology is not uncommon in patients with " 1712 2009 W4281566253.pdf 9 27 separator 0.92437136 ¶ 2009 2010 W4281566253.pdf 9 28 paratext 0.98013085 Page 10 of 16F1000Research 2022, 10:552 Last updated: 12 DEC 2023 2011 2077 W4281566253.pdf 9 0 paratext 0.970923 "¶ J.U. Okoye e t al. / NIPES Journal of Science and Technology Research 5(1) 20 23 pp. 179-194" 1 100 W4324126658.pdf 15 1 separator 0.8733422 ¶ 101 103 W4324126658.pdf 15 2 paratext 0.9351688 194 103 107 W4324126658.pdf 15 3 separator 0.90253943 ¶ 108 110 W4324126658.pdf 15 4 title 0.8886947 "the government to the incessant building" 111 155 W4324126658.pdf 15 5 text 0.36033493 ¶ 156 158 W4324126658.pdf 15 6 title 0.4207148 158 159 W4324126658.pdf 15 7 text 0.37757236 collapse 159 167 W4324126658.pdf 15 8 table 0.472872 169 170 W4324126658.pdf 15 9 text 0.5296345 ¶ Undergoing illegal 170 190 W4324126658.pdf 15 10 table 0.47374797 191 192 W4324126658.pdf 15 11 text 0.5330588 ¶ constructs by the owner 192 217 W4324126658.pdf 15 12 separator 0.9769398 ¶ 219 221 W4324126658.pdf 15 13 contact 0.78191954 "175 No 32 , Ibadan Street, Off Herbal Macaulay Way, Ebute -Meta" 221 291 W4324126658.pdf 15 14 table 0.9224995 "3 storey Building April, 1st 2022 10 death Failed integrity test mark for demolition, some occupants left but the rest material testing" 292 443 W4324126658.pdf 15 15 separator 0.91147995 ¶ 445 447 W4324126658.pdf 15 16 contact 0.7816699 "176 Chris Igade Street, Off Ago Palace Wary, Opposite Kilamajaro/AP , Lagos State" 447 539 W4324126658.pdf 15 17 table 0.96618056 "2 storey building May 7th 2022 No casualty was recorded during the incident Structural defects" 540 653 W4324126658.pdf 15 18 separator 0.596583 ¶ 655 657 W4324126658.pdf 15 19 contact 0.65791094 "177 Freeman Street, Lagos Island, Lagos" 657 700 W4324126658.pdf 15 20 table 0.97300756 "2 storey building May 21st 2022 1 dead Heavy downpou r (rainfall)/structural failure" 701 795 W4324126658.pdf 15 21 separator 0.5798919 ¶ 797 799 W4324126658.pdf 15 22 text 0.39651465 Source 799 806 W4324126658.pdf 15 23 table 0.41507745 : 806 807 W4324126658.pdf 15 24 text 0.5015478 [2 807 810 W4324126658.pdf 15 25 table 0.40285265 , 810 811 W4324126658.pdf 15 26 text 0.4426647 3,4,5,6,7 811 820 W4324126658.pdf 15 27 table 0.41148052 ] 820 821 W4324126658.pdf 15 28 separator 0.98334235 "¶ ¶" 823 833 W4324126658.pdf 15 0 paratext 0.92074776 EUROPEJSKIE STUDIA HUMANISTYCZNE: Państwo i Społeczeństwo Issue 3, 2014-201591 0 85 W4390429233.pdf 7 1 title 0.8134439 precedes data collection. 85 110 W4390429233.pdf 7 2 text 0.8541684 "Before proceeding to the evaluation of the model the researcher has to deal with issues related to the sample size and data validation." 110 252 W4390429233.pdf 7 3 separator 0.9941125 ¶ 252 254 W4390429233.pdf 7 4 text 0.9994016 "Sample size . Determining the size of the sample, some researchers consider the following requirements: error model specifications, the complexity of models used and the method of assessment model features of the distribution of observed variables [4, 8]. The error specification of the model can be called in case of exclusion or inclusion of certain variables or parameters. The sample size affects the probability of a correct evaluation of the model and the definition of the error specification. Typically when a complexity of the model is increased the volume of the sample is increased too." 254 876 W4390429233.pdf 7 5 separator 0.9857631 ¶ 876 878 W4390429233.pdf 7 6 text 0.9995836 "The useful rule for determining the sample size depending of the complexity of the model is suggested by R.B. Kline [8, p.12]. This N / q rule, where N – number of participants, and q – the number of model parameters that require statistical estimates. The ideal ratio of sample size to parameters is 20:1. Less ideal ratio is 10:1." 878 1223 W4390429233.pdf 7 7 separator 0.98982346 ¶ 1223 1225 W4390429233.pdf 7 8 text 0.9995189 "Multicollinearity . This applies to situations where the measured variables (indicators) are too closely related. This is a problem for the application of the method of SEM, because researchers use related indicators as indicators of constructs and if these figures are too strongly connected they can influence certain statistical tests results. The common practice to check the data for multicollinearity is to calculate the bivariate correlations for all measured variables. Any pair of variables with correlations greater than r = 0,85 causes potential problems. In such cases one of these two variables should be excluded from further analysis." 1225 1899 W4390429233.pdf 7 9 separator 0.99365866 ¶ 1899 1901 W4390429233.pdf 7 10 text 0.9947264 "Multivariate normal . Commonly used methods of LSG suggest that multivariate distribution usually has a normal distribution. R.B. Kline (2005) showed that if all the one-dimensional distributions are normal, and the joint distribution of any pair of variables is bivariate normal." 1901 2191 W4390429233.pdf 7 11 separator 0.90023124 ¶ 2192 2194 W4390429233.pdf 7 12 text 0.9991541 "Violation of these assumptions can affect the accuracy of the statistical tests in structural equation modeling. Multivariate normality is investigated using the normalized multivariate kurtosis values which is called Mardia." 2194 2426 W4390429233.pdf 7 13 separator 0.61306864 ¶ 2427 2429 W4390429233.pdf 7 14 text 0.99958915 "This is done by comparing the coefficient data Mardia for studies with values calculated according to the formula p × (p + 2), where p is equal to the number of observed variables in the model. If the coefficient of Mardia lower than the value obtained from the above formula the data are considered as multivariate normal." 2429 2765 W4390429233.pdf 7 15 separator 0.9947641 ¶ 2765 2767 W4390429233.pdf 7 16 text 0.9891958 Missing data . The presence of missing data often occurs due to factors 2767 2839 W4390429233.pdf 7 0 paratext 0.9698677 "92 СЛОБОЖАНСЬКИЙ НАУКОВО-СПОРТИВНИЙ ВІСНИК  2014  No2 (40)ISSN 1991-0177" 0 75 W2280697408.pdf 2 1 separator 0.9919451 ¶ 75 77 W2280697408.pdf 2 2 text 0.99876755 "для отримання найвищої оцінки, він становить 10 хв для хлопців і 11.30 хв для дівчат . У віці 15 років норма - тив є більшим і становить 9 хв та 10.30 хв для хлопців та дівчат відповідно. Якщо перевести ці показники у метричні виміри, то 1600 м 13-річний учень мав би до - лати за 10 хв (табл. 1)." 77 388 W2280697408.pdf 2 3 separator 0.9853602 ¶ 388 390 W2280697408.pdf 2 4 text 0.9901155 "Надалі зупинимося на аналізі нормативів спрямо - ваних на визначення рівня розвитку сили. В Україні, діючою навчальною програмою запропоновано тесто - вий норматив підтягування на перекладені для хлоп - ців та модифікований вид підтягування для дівчат [5]." 390 659 W2280697408.pdf 2 5 separator 0.56259584 ¶ 659 661 W2280697408.pdf 2 6 text 0.9844656 "Схожий підхід пропонується і навчальною програ - мою з фізичного виховання у Російській Федерації . " 661 765 W2280697408.pdf 2 7 separator 0.5676806 ¶ 765 766 W2280697408.pdf 2 8 text 0.9981972 "Однак, слід звернути увагу на те, що норматив для дівчат з віком зменшується. Можливо, це пов’язано з природним зменшенням показників відносної сили, що власне і враховано діючою програмою." 766 965 W2280697408.pdf 2 9 separator 0.97842604 ¶ 965 967 W2280697408.pdf 2 10 text 0.99935406 "У США оцінка силових можливостей здійснюєть - ся тестовою вправою, яка складається з трьох різних вправ, а саме: з гинання-розгинання рук в упорі лежа - чи; підтягування; вис на перекладені . У табл. 2 зазна - чені нормативи оцінки розвитку сили." 967 1220 W2280697408.pdf 2 11 separator 0.973953 ¶ 1220 1222 W2280697408.pdf 2 12 text 0.99919355 "Як бачимо, тестовий норматив у СшА диферен - ційовано таким чином, щоб кожен учень міг проявити себе у виконанні певної рухової дії [7; 10]. Такий під - хід характерний саме для навчальних програм СшА та Польщі, де учням для складання тестових норма - тивів пропонуються альтернативні способи рухової діяльності. Для практики фізичного виховання Росії та України характерний консервативніший підхід з уніфі - кованими вимогами." 1222 1670 W2280697408.pdf 2 13 separator 0.9668887 ¶ 1670 1672 W2280697408.pdf 2 14 text 0.99842316 "Для оцінки рівня розвитку швидкості навчаль - ними програмами з фізичного виховання України , Російської Федерації та Польщі , пропонується за - стосовувати біг на короткі дистанції. У Польській Рес - публіці, однак, дистанція є більшою і становить 60 м, на відміну від України та Російської Федерації, де ана - логічний норматив складається на дистанції 30 м." 1672 2048 W2280697408.pdf 2 15 title 0.9553052 Таблиця 3 2048 2057 W2280697408.pdf 2 16 separator 0.9720496 ¶ 2057 2059 W2280697408.pdf 2 17 title 0.96779 Нормативи оцінки розвитку швидкості в різних країнах 2059 2112 W2280697408.pdf 2 18 separator 0.94454473 ¶ 2112 2114 W2280697408.pdf 2 19 table 0.99370944 "Вік (роки)Україна Російська Федерація Польща США Біг 30 м, с Біг 30 м, с Біг 60 м, с Нормативи не визначеноХлопці Дівчата Хлопці Дівчата Хлопці Дівчата 13 5,4 5,8 4,8 5,0 8,8 9,4 14 5,2 5,6 4,7 4,9 8,4 9,3 15 5.0 5.5 4,5 4,9 8,2 9,2" 2114 2362 W2280697408.pdf 2 20 separator 0.9729608 ¶ 2362 2364 W2280697408.pdf 2 21 title 0.914394 Таблиця 4 2364 2374 W2280697408.pdf 2 22 separator 0.7654572 ¶ 2374 2376 W2280697408.pdf 2 23 title 0.8709082 Нормативи оцінки розвитку гнучкості в різних країнах 2376 2429 W2280697408.pdf 2 24 separator 0.8637805 ¶ 2429 2431 W2280697408.pdf 2 25 table 0.98108596 "Вік (роки)Україна Російська Федерація Польща США Нахил тулуба уперед із положення сидячи (см)Нахил тулуба уперед із положення сидячи (см)Повільний нахил вперед з основної стійкиНахилу з вихідного положення «сід» (см) Хлопці Дівчата Хлопці Дівчата Хлопці Дівчата Хлопці Дівчата 13 7 12 9 18 Г оловою торкнутися колін26 31 14 8 13 11 20 28 33 15 9 14 12 20 30 36" 2431 2828 W2280697408.pdf 2 26 separator 0.95918536 ¶ 2828 2830 W2280697408.pdf 2 27 title 0.8917442 Таблиця 5 2830 2840 W2280697408.pdf 2 28 separator 0.7687775 ¶ 2840 2842 W2280697408.pdf 2 29 title 0.9074211 Нормативи оцінки розвитку швидкісно-силових здібностей в різних країнах 2842 2914 W2280697408.pdf 2 30 separator 0.93597925 ¶ 2914 2916 W2280697408.pdf 2 31 table 0.8557377 "Вік (роки)Україна Російська Федерація Польща Стрибок у довжину з місця (см)Стрибок у довжину з місця (см)Стрибок у довжину з місця. Результат вимірюється стопами. В обчисленнях результат заокруглюється: менше, ніж пів стопи – знижується; більше, ніж пів стопи – зростає" 2916 3207 W2280697408.pdf 2 32 separator 0.718211 ¶ 3207 3209 W2280697408.pdf 2 33 table 0.99416906 "Хлопці Дівчата Хлопці Дівчата 10 стоп13 180 160 205 200 14 185 165 210 200 15 200 170 220 205" 3209 3309 W2280697408.pdf 2 34 bibliography 0.9917307 МАНДЮК А. Б., ЯРОШИК М. Я., ЛІТКЕВИЧ О. А. Порівняльний аналіз тестів рівня фізичної підготовленості 3309 3409 W2280697408.pdf 2 0 paratext 0.9830012 Manishaa. V et al., Journal of Biomedical and Pharmaceutical Research 0 70 W2974250592.pdf 4 1 separator 0.63580036 "¶ " 72 81 W2974250592.pdf 4 2 paratext 0.8989136 ¶ 35 | 81 87 W2974250592.pdf 4 3 title 0.8074252 P a g e 87 95 W2974250592.pdf 4 4 separator 0.70619845 ¶ 97 99 W2974250592.pdf 4 5 title 0.6739826 attributed to 100 114 W2974250592.pdf 4 6 text 0.6014377 the increased 114 128 W2974250592.pdf 4 7 title 0.562884 s 128 130 W2974250592.pdf 4 8 text 0.6926668 "taining capacity of beer." 130 158 W2974250592.pdf 4 9 separator 0.83371794 ¶ 160 162 W2974250592.pdf 4 10 text 0.96272963 "Though in vitro, this study will still be able to give both clinicians and patients the ability to evaluate the effect of patient’s lifestyle habits on dental restorative treatment procedu res." 162 365 W2974250592.pdf 4 11 separator 0.9948359 ¶ 366 368 W2974250592.pdf 4 12 title 0.9831513 Conclusion 368 379 W2974250592.pdf 4 13 separator 0.9941162 ¶ 381 383 W2974250592.pdf 4 14 text 0.9945546 From this study, the following can be concluded: 383 432 W2974250592.pdf 4 15 separator 0.8275734 ¶ 434 436 W2974250592.pdf 4 16 text 0.98948133 " All beverages cause a perceptible and undesirable colour change of currently available composite resin restorations that have a ΔE* > 3.3.  Red wine produced the maximum colour change.  The c olour change was time -dependent i.e., the colour change intensified with increased contact time." 436 753 W2974250592.pdf 4 17 separator 0.99546313 ¶ 755 757 W2974250592.pdf 4 18 title 0.7451829 References 757 768 W2974250592.pdf 4 19 separator 0.98963785 ¶ 770 772 W2974250592.pdf 4 20 bibliography 0.99755675 "1. BL Tan, AUJ Yap, HNT Ma J Chew, WJ Tan. Effect of Beverages on Color and Translucency of New Tooth -Colored Restoratives. Operative Dentistry, 2015. 40(2):56 -65." 772 947 W2974250592.pdf 4 21 separator 0.9420327 ¶ 948 950 W2974250592.pdf 4 22 bibliography 0.99768883 "2. Oliveira WJ, Bikharinho LJR, Abud MA. Does amalgam restoration belong to the past? Pesquisa Brasileira em Odontopediatria e Clinica Integrada, 2005. 9(48):39 -48." 950 1125 W2974250592.pdf 4 23 separator 0.97057515 ¶ 1127 1129 W2974250592.pdf 4 24 bibliography 0.99730146 "3. Nahsan FPS, Baseggio W, Schmitt VL, Walker CS, Mondelli RFL, Franco EB. Selection of color and natural stratification for aesthetic rehabilitation of anterior tooth . Dental Press Estét Maringá, 2011. 8(3):100 - 106." 1129 1367 W2974250592.pdf 4 25 separator 0.9720956 ¶ 1369 1371 W2974250592.pdf 4 26 bibliography 0.9978428 "4. Braga SR, Vasconcelos BT, Macedo MR, Martins VR, Sobral MA. Reasons for placement and replacement of direct resto rative materials in Brazil. Quintessence Int, 2007. 38(4):189 -194." 1371 1565 W2974250592.pdf 4 27 separator 0.9663495 ¶ 1567 1569 W2974250592.pdf 4 28 bibliography 0.9970815 "5. Ashok NG, Jayalakshmi S. Factors that influence the color stability of composite restorations. International Journal Orofacial Biology, 2017. 1(1):1 -3." 1569 1734 W2974250592.pdf 4 29 separator 0.9539366 ¶ 1735 1737 W2974250592.pdf 4 30 bibliography 0.99760526 "6. Um CM, Ruyter IE. Staining of resin -based veneering materials with coffee and tea. Quintessence International, 1991.22:377386. 377 - 386." 1737 1887 W2974250592.pdf 4 31 separator 0.98165417 ¶ 1889 1891 W2974250592.pdf 4 32 bibliography 0.99683136 "7. Fulya Toksoy Topcua, Gunes Sahinkesena, Kivanc Yamanelb, Ugur Erdemirc, Elif Aybala Oktaya, Seyda Ersahana. Influence of Different Drinks on the Colour Stab ility of Dental Resin Composites. European Journal of Dentistry, 2009. Volume 3, 50 -56. 8. Satou N, Khan AM, Matsumae I, Satou J, Shintani H. In vitro colour change of composite - based resins. Dental Materials, 1989. 5(6):384 -387." 1891 2307 W2974250592.pdf 4 33 separator 0.9702653 ¶ 2309 2311 W2974250592.pdf 4 34 bibliography 0.99761426 "9. Bansal K, Acharya SR, Sarasw athi V. Effect of alcoholic and non -alcoholic beverages on color stability and surface roughness of resin composites: An in vitro study. Journal of Conservative Dentistry, 2012. 15(3):283 -288." 2311 2550 W2974250592.pdf 4 35 separator 0.97722685 ¶ 2552 2554 W2974250592.pdf 4 36 bibliography 0.9975984 "10. Mildred M. Maldonado -Molina, Jennifer M. Reingle, Amy L. Toble r, and Kelli A. Komro. Effects of beverage -specific alcohol consumption on drinking behaviors among urban youth. Journal of Drug Education, 2010. 40(3):265 –280." 2554 2798 W2974250592.pdf 4 37 separator 0.9687179 ¶ 2800 2802 W2974250592.pdf 4 38 bibliography 0.99773186 "11. Paul S, Peter A, Pietrobon N, Hämmerle CHF. Visual and spectrophotometric shade analysis of hum an teeth. Journal of Dental Research, 2002. 81(8):578 - 582." 2802 2971 W2974250592.pdf 4 39 separator 0.96606386 ¶ 2973 2975 W2974250592.pdf 4 40 bibliography 0.9969051 "12. CIE (Commission International de l’Eclairage) Colourimetry technical report. CIE Publication No.15. 2. Vienna, Austria: Bureau Central de la CIE; 1986." 2975 3142 W2974250592.pdf 4 41 separator 0.97375894 ¶ 3144 3146 W2974250592.pdf 4 42 bibliography 0.99779946 "13. Abu-Bakr N, Han L, Okamoto A, Iwaku M. Color stability of compomer after immersion in various media. Journal of Esthetic Restorative Dentistry, 2000.12:258 -263." 3146 3322 W2974250592.pdf 4 43 separator 0.9620799 ¶ 3324 3326 W2974250592.pdf 4 44 bibliography 0.99746764 "14. Gupta R, Parkash H, Shah N, Jain V. A spectrophotometric evaluation of color changes of various tooth colored veneering materials after exposure to commonly consumed beverages. Journal of Indian Prosthodontic Society, 2005. 5:72–78." 3326 3580 W2974250592.pdf 4 45 separator 0.9776312 ¶ 3581 3583 W2974250592.pdf 4 46 bibliography 0.9970911 "15. Guler AU, Yilmaz F, Kulunk T, Guler E, Kurt S. Effects of different drinks on stainability of resin composite provisional restorative materials. Journal of Prosthetic Dentistry, 2005. 94(2):118 ‐124." 3583 3799 W2974250592.pdf 4 47 separator 0.9660839 ¶ 3801 3803 W2974250592.pdf 4 48 bibliography 0.99731874 "16. Gupta G, Gupta T. Evaluation of the effect of various beverages and food material on the color stability of provisional materials – an in vitro study. J Conserv Dent 2011;14:287 -92." 3803 3999 W2974250592.pdf 4 49 separator 0.97224414 ¶ 4000 4002 W2974250592.pdf 4 50 bibliography 0.99760514 "17. Andreas Faltermeier, Michae l Behr and Dieter Mubig. In vitro colour stability of aesthetic brackets. European Journal of Orthodontics, 2007. 29:354 –358." 4002 4170 W2974250592.pdf 4 51 separator 0.9696567 ¶ 4172 4174 W2974250592.pdf 4 52 bibliography 0.9977221 "18. R. Bagheri, M.F. Burrow, M. Tyas. Influence of food -simulating solutions and surface finish on susceptibility to staining of aesth etic restorative materials. Journal of Dentistry, 2005. 33:389 –398." 4174 4388 W2974250592.pdf 4 53 separator 0.9761239 ¶ 4390 4392 W2974250592.pdf 4 54 bibliography 0.9977155 "19. Eick JD, Smith RE, Pinzino CS, Kostoryz EL. Stability of silorane dental monomers in aqueous systems. Journal of Dentistry, 2006. 34:405 -410." 4392 4545 W2974250592.pdf 4 55 separator 0.97210205 ¶ 4547 4549 W2974250592.pdf 4 56 bibliography 0.99754083 "20. Ertas E, Guler AU, Yucek AÇ, Koprulu0 H, Guler E. Color stability on resin composites after immersion in different drinks. Journal of Dental Materials, 2006. 25(2):371 -376" 4549 4736 W2974250592.pdf 4 0 paratext 0.90062135 "Advancing Women In Leadership Journal Volume 30 , 2010 ¶ 5" 0 64 W4323019671.pdf 4 1 separator 0.99319077 ¶ 65 67 W4323019671.pdf 4 2 text 0.99526894 "Demographic items in the survey included students’ major, ethnicity, gender, and marital status. Students were also asked to report the average number of hours (per week) that they spent conducting research in the lab and to rate their self -confidence level at two points in their program -- when entering graduate school, and at the time of the study. ¶ The survey -questionnaire also included an open -ended question in which students we re asked to describe their department to a prospective graduate student. Student interviews were used to clarify and/or discuss in greater depth individual student’s responses to the items on the survey, and to explore additional issues/themes that emerged in their responses." 69 810 W4323019671.pdf 4 3 separator 0.96823347 ¶ 812 814 W4323019671.pdf 4 4 text 0.9995763 "The faculty members’ perspectives on their department were obtained from one interview question in which they were asked to describe their department to a prospective graduate student. The interviews were audio taped and took between 30 and 60 minutes each. Departmental records were used to determine the faculty and student composition of each department, student undergraduate and graduate grade -point average (GPA), and the student attrition rate (female and male) over a nine -year per iod." 815 1322 W4323019671.pdf 4 5 separator 0.9939596 ¶ ¶ 1324 1330 W4323019671.pdf 4 6 title 0.99216557 Data Analyses 1330 1344 W4323019671.pdf 4 7 separator 0.9851897 ¶ ¶ 1346 1352 W4323019671.pdf 4 8 text 0.99967164 "Analysis of variance was used to determine significant gender differences in student responses to the survey -questionnaire, their age, graduate and undergraduate GPA, and the weekly number of hours spent in the lab conducting research. Chi -square tests were used to determine significant gender differences in the student attrition rate and in their ratings of their self-confidence level before entering graduate school and at the time of the study." 1352 1817 W4323019671.pdf 4 9 separator 0.98265743 ¶ 1819 1821 W4323019671.pdf 4 10 text 0.9995227 "The transcripts of the faculty and student interviews and of student comments to the items on the survey were analyzed using the techniques of naturalistic inquiry (Lincoln & Guba, 1985; Miles & Huberman, 1994). After the interview tapes were transcribed verbatim and students’ comments to the survey questions copie d, each comment was coded with the respondent’s assigned code number, department and gender. As each transcript was read and categorical themes were identified, a text -based coding was used (Miles & Huberman, 1994). While categorical themes were identified , markings were made on the margins of the transcripts to code each theme (e.g., “competition”; “collegiality”; “sense of isolation”). These codes were revised and new ones added as the transcripts were read several times. The accuracy of the themes was accomplished through “member checking” and a peer reviewer (Lincoln & Guba, 1985)." 1822 2753 W4323019671.pdf 4 11 separator 0.9915688 ¶ ¶ 2756 2762 W4323019671.pdf 4 12 title 0.9601698 Results 2762 2770 W4323019671.pdf 4 13 separator 0.98910165 ¶ ¶ 2772 2778 W4323019671.pdf 4 14 text 0.9996784 "Statistical analyses of the data did not uncover significant gender differences in: (a) students’ age, (b) their undergraduate and graduate grade point average, (c) the ratings of their incoming self -confidence level, and (d) the weekly number of hours spent conducting research in the laboratory. However, significant gender differences were found in the student attrition rate and in the ratings of their self -confide nce at the time of the study. The attrition rate of female students, over a nine -year period, was significantly larger than that of males X 2 (1, N = 726) = 14.81, p = .001 and was significantly higher in the chemistry department X2 (1, N = 726) = 12.86," 2778 3470 W4323019671.pdf 4 0 paratext 0.912626 Angelina, P., Kartadinata, S., & Budiman, N. (2021) 0 51 W3176400224.pdf 1 1 separator 0.9166265 "¶ ¶" 53 63 W3176400224.pdf 1 2 paratext 0.96685183 306 Ta’dibuna, Vol. 10, No. 2, Juni 202 1 63 107 W3176400224.pdf 1 3 title 0.99189377 I. Pendahuluan 107 122 W3176400224.pdf 1 4 separator 0.9945946 ¶ 124 126 W3176400224.pdf 1 5 text 0.99678636 "Undang -undang No. 20 tahun 2003 tentang Si stem Pendidikan Nasional menyatakan bahwa pendidikan adalah usaha sadar dan terencana untuk mewujudkan suasana belajar dan proses pembelajaran agar peserta didik secara aktif mengembangkan potensi dirinya sehingga memiliki kekuatan spiritual keagamaan, pen gendalian diri, kepribadian, kecerdasan, akhlak mulia, serta keterampilan yang diperlukan oleh dirinya, masyarakat, bangsa dan negara. Amanat undang -undang ini menjadi pedoman segenap insan pendidikan untuk menyamakan langkah dalam usaha mencapai cita -cita tersebut. Oleh karenanya, sebagai seorang pendidik, perlu mengetahui kompetensi apa yang harus dimiliki untuk meraih tujuan pendidikan nasional dan bagaimana cara mewujudkannya sebagaimana amanah dalam pasal 8 Undang -undang Nomor 14 Tahun 2005 tentang Gur u dan Dosen." 126 986 W3176400224.pdf 1 6 separator 0.9698201 ¶ 988 990 W3176400224.pdf 1 7 text 0.9989449 "Pendidikan merupakan salah satu komponen penting dalam membentuk sebuah peradaban. Komponen dalam dunia pendidikan sebagai unsur holistik yang utuh, berkontribusi dalam menyokong keberhasilan dalam mencetak tingginya peradaban sebuah bangsa. K ita bisa lihat bagaimana Negara Jepang ketika selesai perang dunia, pertanyaan yang pertama di ajukan adalah, berapa orang guru yang tersisa (Taufik, 2019)." 990 1406 W3176400224.pdf 1 8 separator 0.9795319 ¶ 1408 1410 W3176400224.pdf 1 9 text 0.9994563 "Indonesia sebagai salah satu negara yang memiliki sumber daya manusia dan sumber daya alam yang ba nyak, akan segera menjemput bonus demografinya (PPN/Bappenas, 2017). Di saat yang bersamaan, China, Rusia, Jepang dan Jerman mengalami krisis demografi (Armandhanu, 2015). Jepang yang mengalami krisis demografi, mengalami sebuah tantangan berkurangnya popu lasi yang membuat penduduk/pekerja usia produktif berkurang sehingga Jepang berusaha memperbaiki kondisi tersebut dengan menerapkan Society 5.0 (Yuliardi, 2020). Indonesia tidak boleh lengah, sehingga kita masih harus perlu lebih serius dalam membawa arah pendidikan negeri ini dengan berlimpahnya sumber daya alam dan sumber daya manusia yang dimiliki." 1410 2146 W3176400224.pdf 1 10 separator 0.97995174 ¶ 2148 2150 W3176400224.pdf 1 11 text 0.99884784 "Terdapat hal -hal yang mewarnai catatan sejarah dunia pendidikan negeri ini. Tercatat sudah beberapa kali negeri ini me ngubah kurikulum sejak negeri ini merde ka hingga sekarang, mulai dari perubahan yang minimalis sampai maksimal (Muhammedi, 2016)." 2150 2407 W3176400224.pdf 1 12 separator 0.67159736 ¶ 2408 2410 W3176400224.pdf 1 13 text 0.99914885 "Belum lagi draf peta pendidikan nasional 2020 -2035 Indonesia yang sempat menghilangkan frase kata agama dan saat ini masih menjadi polemik ( CNN Indonesia, 2021). Ter masuk profesi guru yang saat ini tidak lagi menjadi salah posisi sebagai Pegawai Negeri Sipil (PNS) dan kesejahteraan guru honorer yang belum memadai (Bramasta , 2021)." 2410 2760 W3176400224.pdf 1 14 separator 0.98153853 ¶ 2762 2764 W3176400224.pdf 1 15 text 0.99944633 "Saat ini dunia sedang mengalam era disrupsi. Kemajuan teknologi berdampak pada tatanan k ehidupan dunia. Muncul banyak profesi baru seiring dengan banyaknya profesi yang hilang. Termasuk pelaksanaan profesi pembelajaran dikelas. Sebagai contoh adalah" 2764 3021 W3176400224.pdf 1 0 paratext 0.97863466 "[Marinho et. al. , Vol.8 (Iss.1): January 2020] ISSN - 2350 -0530(O) , ISSN - 2394 -3629(P) Index Copernicus Value (ICV 2018): 86.20 DOI: 10.5281/zenodo.3633270 Http:// www.granthaalayah.com ©International Journal of Research - GRANTHAALAYAH [229]" 0 305 W4287898340.pdf 8 1 separator 0.99522877 ¶ 306 308 W4287898340.pdf 8 2 text 0.9994363 "Starting from the Koopmans theorem, the global reactivity descriptors (generated from the HOMO -LUMO relationship) describe chemical properties that indicate the types of interactions between ligand mo lecules with biological receptors, since they act as mediators between reactivity and stability. Among these descriptors are: vertical ionization potential (I), electronic affinity (A), electronegativity (χ), chemical hardness (η), chemical softness (S), e lectronic chemical potential (μ) and electrophilicity index (ω) [29] [44].The ionic potential (I), related to the energy of the HOMO orbital, indicates the strength of an electron's strength when it is attached to an atom." 309 1009 W4287898340.pdf 8 3 separator 0.92183506 ¶ 1010 1012 W4287898340.pdf 8 4 text 0.9995853 "Electronic affinity (A), related to the energy of LUMO, represents the amount of energy released when an atom or molecule receives an electron [45]. Electronegativity is represented by the ability of a molecule to attract electrons from another molecular when they interact, interfering in the dipolar moment and changing molecular properties such as the acidity and basicity of different molecules [27]. Starting from Methylcytisine HOMO -LUMO boundary molecular orbitals, it was possible to determine the global chemical reactivity descriptors (Table 5), where the molecule had a lower GAP value than Cytisine reference, due to the fact that it has lower values of electro affinity and ionic potential than Cytisine. Methylcytisine also showed lower electronegativity and chemical hardness values than Cytsine." 1012 1851 W4287898340.pdf 8 5 separator 0.9920684 ¶ ¶ 1853 1859 W4287898340.pdf 8 6 title 0.9661939 Table 5 : Global Reactivity Descriptors calculated for Methylcytisine and Cystisine 1859 1943 W4287898340.pdf 8 7 separator 0.97621924 ¶ 1945 1947 W4287898340.pdf 8 8 table 0.99456275 "Descriptors Methylcytisine Cytisine Eléctron affinity (A) 0.12470 0.33701 GAP 8.34805 8.35463 Eletronegativity (χ) 4.29872 4.51432 Vertical Ionization potential (I) 8.47275 8.69164 Chemical hardness (η) 4.17402 4.17731 Chemical softness (S) 0.11978 0.11969 Eletronic chemical potential (μ) -4.29872 -4.51432 Electrophilicity index (Ω) 2.21345 2.43926" 1947 2348 W4287898340.pdf 8 9 separator 0.980909 ¶ ¶ 2350 2356 W4287898340.pdf 8 10 title 0.9926296 3.4. Mulliken Population Analysis 2356 2390 W4287898340.pdf 8 11 separator 0.9886734 ¶ ¶ 2392 2398 W4287898340.pdf 8 12 title 0.97849727 Mulliken atomic charges ( Mulliken population analysis) and electrostatic potential surface map 2398 2494 W4287898340.pdf 8 13 separator 0.99377346 ¶ 2495 2497 W4287898340.pdf 8 14 text 0.99798495 "Mulliken population analysis divide the charge densities between atoms evenly disregarding electronegativity. When studying the Mulliken charges of Methylcytisin e, the existence of varying charges of atoms of the same nature is notorious, where carbon atoms vary from -0.3405 to 0.3035, nitrogen at -0.0954 to 0.0983 and atoms of hydrogens 0.0859 to 0.2280 [46]. ¶ The visualization and analysis of charges is possible through the surface map of electrostatic potential, as it allows to characterize electrophilic and nucleophilic regions, showing how complex molecules interact [47] [47]. Through the MESP of Methylcytisine (Figure 5) it was possible to notice defined regi ons, since the regions in red mean regions with a high concentration of charges and the regions in white have a low concentration of charge. The regions highlighted in red are due to the presence of a nitrogen atom (N13) and oxygen since they are more elec tronegative atoms than carbons and hydrogens." 2497 3510 W4287898340.pdf 8 0 paratext 0.9903891 Energies 2020 ,13, 3142 16 of 24 0 32 W3035986397.pdf 15 1 separator 0.9928191 ¶ 32 34 W3035986397.pdf 15 2 text 0.9995666 "out that the existence of contact thermal resistance seriously restricted the performance of the temperature generator. Wang et al. [ 154] investigated the influence of the thermal contact resistance on TE performance by experiment. They demonstrated that the performance of a TE device can be significantly improved by reducing the contact thermal resistance." 34 399 W3035986397.pdf 15 3 separator 0.906508 ¶ 399 401 W3035986397.pdf 15 4 text 0.9997514 "Actually, for some practical applications, in order to improve the TE devices’ performance, many methods have been used to reduce the contact thermal resistance. The most frequently used method is to sandwich a material with high thermal conductivity between the TE module and the heat source for decreasing their thermal contact resistance [ 158]. In addition, the thermal grease and conductive adhesive are often used to decrease the thermal resistance of two contact surfaces. It is the same as for a thermal adhesive, as the use of a high thermal conductivity is an e ective way to reduce thermal contact resistance. The performance of the TEG has been significantly improved by reducing the contact resistance at the thermal interface [159–161]." 401 1166 W3035986397.pdf 15 5 separator 0.9627875 ¶ 1166 1168 W3035986397.pdf 15 6 text 0.9997243 "Nowadays, more suitable thermal interface materials (TIM) are used to improve the operation performance of TE modules in di erent locations and working conditions. These include inorganic compounds [ 162], greases [ 163], graphite [ 164], metal nanometer material [ 165], and carbon materials. The results [ 153] showed that the boron nitride-based ceramic coating, white coating and polyurethane-based sheet are suitable for reducing contact resistance, respectively. The thermal resistance decreases and leads to the increase in temperature r by between 13% and 15%. In addition, close physical contact between contact surfaces is essential to minimize heat losses at the interface." 1168 1866 W3035986397.pdf 15 7 separator 0.8710824 ¶ 1866 1868 W3035986397.pdf 15 8 text 0.99965584 "This kind of contact plays an increasingly prominent role in the heat-energy collection of curvy surfaces’ heat sources. However, conventional TE modules based on hard and brittle ceramic substrates are not viable for applications where surface irregularities or irregular surface shapes." 1868 2161 W3035986397.pdf 15 9 separator 0.86169195 ¶ 2161 2163 W3035986397.pdf 15 10 text 0.99952227 "The development of highly flexible and stretchable thermoelectric modules that are pliable to curvy and deformable surfaces are urgently needed. This challenge has driven the advent of flexible and stretchable TE modules in recent decades, which created a wide range of revolutionary functional TE devices including the liquid alloy [ 166], silk-fabric [ 167] as well as printed [ 168] and printing technologies [ 169]. The manufacturing is realized by the customized layer-by-layer manufacturing process where some special methods are used to reduce the contact thermal resistance. Karwa et al. [ 170] designed an on-line restriction injection array heat sink in which the coolant was directly impinging on the thermoelectric module to reduce the thermal resistance of the interface. The experimental and simulation results show that a low thermal resistance 0.025 K /W can be obtained." 2163 3065 W3035986397.pdf 15 11 separator 0.9959697 ¶ 3065 3067 W3035986397.pdf 15 12 title 0.9930346 6. Conclusions and Further Research Direction 3067 3113 W3035986397.pdf 15 13 separator 0.9953518 ¶ 3113 3115 W3035986397.pdf 15 14 text 0.99962217 "Considering today’s energy and environmental crisis, thermoelectric modules are an application with good prospects for thermoelectric generation and thermoelectric cooling in the future. Due to the low thermoelectric conversion rate, it is still urgent to improve thermoelectric modules to promote their commercialization. This paper comprehensively reviews the e orts and methods used to improve properties and enhance the performance of thermoelectrics in terms of material progress, structure /geometry, module construction, thermal management and thermal structure design." 3115 3703 W3035986397.pdf 15 15 separator 0.95093083 ¶ 3703 3705 W3035986397.pdf 15 16 text 0.9968854 "The summaries and corresponding research directions are proposed as follows: (1) The performance of thermoelectric devices is determined by two main factors: the thermoelectric material performance and the thermal structure, which corresponds to Z and temperature T. Thus, there are two corresponding ways to achieve high-performance thermoelectrics: one is for materials, and another is thermal design and optimization. (2) Although a high ZT has been obtained in some low dimensional thermoelectric materials such as superlattices, nanostructures, quantum dots, nanowires, and carbon nanotubes, the highest ZT of thermoelectric materials ever found at ambient temperature is 2.4 or even higher in the lab. However, many of them are not viable for large-scale commercial use at present due to their expensive materials and complex processes. Hence, developing the novel thermoelectric module shapes to order or a flexible thermoelectric module is a good way to address this issue." 3705 4706 W3035986397.pdf 15 0 text 0.68616384 "research and establishing drug interactions with adverse events applying FAERS data." 0 86 W2751944436.pdf 3 1 separator 0.99053043 ¶ 86 88 W2751944436.pdf 3 2 text 0.99778646 "Among all modern antiplatelet strategies, aspirin still remains the cornerstone with the broadest possible utilization." 88 210 W2751944436.pdf 3 3 separator 0.69045174 ¶ 210 212 W2751944436.pdf 3 4 text 0.99424136 "Aspirin irreversibly acetylates a serine residue at position 530 on the cyclooxygenase (COX) enzyme, thus inhibiting the first step in the transformation of arachidonic acid to the platelet agonist thromboxane A 2, a powerful promoterofaggregation.10" 212 468 W2751944436.pdf 3 5 separator 0.7605568 ¶ 468 470 W2751944436.pdf 3 6 text 0.99343157 "The irreversible nature of COX inhibition underlies the ability oflow doses ofaspirin administered chronically, to inhibit platelet aggregation in vivo." 470 625 W2751944436.pdf 3 7 separator 0.6320089 ¶ 625 627 W2751944436.pdf 3 8 text 0.96185994 "11There is a nonlinear relationship of inhibition of platelet thromboxane A 2generation with inhibi- tion of thromboxane-mediated platelet aggregation, requiring in excess of 95% inhibition to in fluence function.12Importantly, most antiplatelet strategies include aspirin as a back-up for newer agents; therefore, any analyses of clinical outcomes associated with patented OAA will not be possible, unless theprecise role of aspirin is clearly identi fied. In fact, our previous experience with FAERS suggests poor quality of event report- ing." 627 1187 W2751944436.pdf 3 9 separator 0.8483043 ¶ 13 1187 1192 W2751944436.pdf 3 10 text 0.9164073 "Clopidogrel monotherapy is common post-stroke, in contrast to prasugrel and ticagrelor which must be used with ASA. Therefore, it was a quality test for FAERS, as prasugrel and ticagrelor cases should mandatorily co-report ASA. However" 1192 1433 W2751944436.pdf 3 11 bibliography 0.49656028 ,these 1433 1439 W2751944436.pdf 3 12 text 0.6229067 data were heavily missed from FAERS. 1439 1476 W2751944436.pdf 3 13 separator 0.96502125 ¶ 1476 1478 W2751944436.pdf 3 14 text 0.99938107 "There are few important considerations which may be yielded from the index data. Indeed, the quality of FAERSreports was similarly average for all antiplatelet agents. There is nothing unique about aspirin reporting quality, and all OAA data are suffering from missing entries. More missing dataafter aspirin are probably attributed to much larger sample size, and domination among all antiplatelet-associated ad- verse events. Alarmingly high rate of nonreported gender inover a quarter of cases is unacceptable. Massive missed or/and unknown demographics preclude from better understandingof the drug safety pro files, somewhat challenging the entire idea behind FAERS. Especially concerning is a high incidence of adverse event reporting during triple antithrombotic strate-gies. This segment should be under close monitoring because novel oral anticoagulants will broadly supplement conven- tional dual antiplatelet strategies. Since the FDA mandates andoversees this valuable huge repository keeping it public, improving the qualityof reportsshould bethe upmost priority." 1478 2576 W2751944436.pdf 3 15 separator 0.98651534 ¶ 2576 2578 W2751944436.pdf 3 16 text 0.99959046 "In fairness, aspirin reporting may be tricky as there arenumerous local manufacturers not complying with the FAERS reporting laws. Such an “orphan ”status of aspirin may be partially responsible for the filing failures. Nevertheless, this study has important practical implications. First and upmost, the quality of the FAERS aspirin reporting is unacceptable, raising concerns about other drugs. Considering that U.S. filing is far better than reports around the globe," 2578 3059 W2751944436.pdf 3 17 separator 0.8903563 ¶ 13 3059 3064 W2751944436.pdf 3 18 text 0.9972992 "it seems the FDA should consider better options to stimulate proper interna- tional reporting, potentially switching such responsibility tothe consumers or health care professionals away from man- ufacturers. Acknowledging sharp decline in ongoing or planned clinical trials with antiplatelet agents, the “real-life ” data from FAERS are de finitely useful if properly managed." 3064 3450 W2751944436.pdf 3 19 separator 0.8116073 ¶ 3450 3452 W2751944436.pdf 3 20 text 0.99767834 "Since FAERS is public, any scientist may access the data and mine this huge repository. Moreover, FAERS maintenance ispaid by U.S. tax dollars, requiring de finite optimization and better surveillance." 3452 3657 W2751944436.pdf 3 21 separator 0.9521256 ¶ 3657 3659 W2751944436.pdf 3 22 text 0.99880904 "There are obvious strengths in our approach with this study. This analysis was conducted within the frame of a government database, requiring mandatory serious event reporting." 3659 3842 W2751944436.pdf 3 23 separator 0.8927226 ¶ 14 3842 3847 W2751944436.pdf 3 24 text 0.9978574 "The data retrieval and analyses were done by one of the authors (T.A.M.) with decades of experience working for the FDA. The sample size was suf ficient to make reasonable conclusions on filing quality. Our study also has some limitations. The FAERS database analyses are always challenged by the often uneven mixture of patientsand reports, since any single event can generate multiple records. Another shortcoming is that FAERS applies compli- cated accounting, making statistical claims for commonadverse events challenging. There are also no mandatory deadlines for updates required by and strictly forced by the FDA; therefore, some data may still be missing or delayed.Another disadvantage is that we did not encompass the entire database, allowing the in-depth examination of the totality of the extracted evidence, but limited our work to themost recent full year (2015) for which the FAERS data are available. Further research should expand demographics beyond age and gender, concomitant use of proton pumpinhibitors, and explore the entire FAERS data, not limited by the annual reports. The causative impact was greater for ticagrelor than for prasugrel or clopidogrel. This finding may reflect how long the drugs have been around, as enthusiasm for reporting AEs may fade over time. Regardless, the con- sistency and magnitude of the observed differences suggestthat the index data are realistic, and should not be disre- garded. The FDA should enforce quality and completeness of aspirin reports for better surveillance." 3847 5416 W2751944436.pdf 3 25 title 0.74929714 Table 5 Most common adverse events after aspirin in FAERS 5416 5473 W2751944436.pdf 3 26 table 0.9932364 "¶ (2015) Adverse event Patients (%) Bleeding 6,756 (14.1%) GI bleeding 3,302 (6.9%)Intracranial bleeding 717 (1.5%) Anemia 2,314 (4.8%) Dyspnea 2,286 (4.8%)Myocardial infarction 798 (1.7%)Stroke 1,422 (3.0%) Acute coronary syndrome 860 (1.8%) Thrombosis 1,015 (2.1%)Thrombosis in device 48 (0.1%) Arrhythmia 1,494 (3.1%) Ventricular arrhythmia 209 (0.4%)Torsade 36 (0.1%) Angioedema 708 (1.5%)" 5473 5887 W2751944436.pdf 3 27 separator 0.92794573 ¶ 5887 5889 W2751944436.pdf 3 28 table 0.8821278 "Abbreviations: FAERS, Food and Drug Administration Adverse Event Reporting System; GI, gastrointestinal." 5889 5996 W2751944436.pdf 3 29 separator 0.97730756 ¶ 5996 5998 W2751944436.pdf 3 30 paratext 0.96014184 TH Open Vol. 1 No. 2/2017Adverse Event Reporting after Aspirin Serebruany et al. e104 5998 6084 W2751944436.pdf 3 31 separator 0.99303865 ¶ 6084 6086 W2751944436.pdf 3 0 text 0.99942946 "for about two seconds and is not part of the new trains. Rather, kinesin-II seems to rely on passive diffusion rather than active transport to return to the base of the cilium, which means that it takes 10 times longer to return than dynein-1b.In most eukaryotic cells, the length of cilia is tightly regulated, and if they are amputated, cilia grow back to the same length as before (Ishikawa and Marshall, 2017 ). But how do cells know how long a given cilium is? The results of Chien et al. suggest that the availability of kine- sin-II at the base provides this information: when a cilium is short, it takes a relatively short time for kinesin-II to diffuse back to the base; how- ever, as the length of the cilium increases, it takes longer for kinesin-II to diffuse back, and its availability to power new IFT trains is reduced, as is the growth rate of the cilium." 0 905 W2888053781.pdf 1 1 separator 0.98787475 ¶ 905 907 W2888053781.pdf 1 2 text 0.9992577 "This study is one step toward a better under- standing of the workings of IFT trains and how cilia regulate their length. However, in some species, such as worms and mammals, kinesins rely on the IFT trains rather than diffusion to return to the base, so it remains unclear how cilia length is maintained in these organisms (Mijalkovic et al., 2017 ;Prevo et al., 2015 ; Williams et al., 2014 ). Previous research sug- gests that several kinases affect the length of cilia, but it is not yet known if these kinases con- trol kinesin motor levels at the base of cilia, or work in a different manner to maintain cilia length ( Ishikawa and Marshall, 2017 ). Muta- tions affecting dynein have been found in several severe ciliopathies and could also affect the cil- ium length, which highlights how important length control is for cilia to work properly ( McI- nerney-Leo et al., 2013 )." 907 1828 W2888053781.pdf 1 3 separator 0.99499625 ¶ 1828 1830 W2888053781.pdf 1 4 contact 0.9959108 "Dhivya Kumar is in the Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, United States Dhivya.Kumar@ucsf.edu http://orcid.org/0000-0002-3737-014X" 1830 2032 W2888053781.pdf 1 5 separator 0.60489595 ¶ 2032 2034 W2888053781.pdf 1 6 contact 0.99626 "Stephen M King is in the Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, United States king@uchc.edu https://orcid.org/0000-0002-5484-5530" 2034 2234 W2888053781.pdf 1 7 separator 0.9907644 ¶ 2234 2236 W2888053781.pdf 1 8 paratext 0.7377819 "Competing interests: The authors declare that no competing interests exist." 2236 2314 W2888053781.pdf 1 9 separator 0.7588655 ¶ 2314 2316 W2888053781.pdf 1 10 paratext 0.9621711 Published 30 October 2017 2316 2342 W2888053781.pdf 1 11 separator 0.9564123 ¶ 2342 2344 W2888053781.pdf 1 12 title 0.7680973 References 2344 2355 W2888053781.pdf 1 13 separator 0.9892062 ¶ 2355 2357 W2888053781.pdf 1 14 bibliography 0.9967146 "Belyy V , Shih SM, Bandaria J, Huang Y, Lawrence RE, Zoncu R, Yildiz A. 2017. PhotoGate microscopy to track single molecules in crowded environments. Nature Communications 8:13978. DOI: https://doi. org/10.1038/ncomms13978 ,PMID: 28071667" 2357 2604 W2888053781.pdf 1 15 separator 0.96314585 ¶ 2604 2606 W2888053781.pdf 1 16 bibliography 0.9977384 "Chien A , Shih SM, Bower R, Tritschler D, Porter ME, Yildiz A. 2017. Dynamics of the IFT machinery at the ciliary tip. eLife 6:e28606. DOI: https://doi.org/10. 7554/eLife.28606 ,PMID: 28930071" 2606 2805 W2888053781.pdf 1 17 separator 0.9930525 ¶ 2805 2807 W2888053781.pdf 1 18 caption 0.9730757 "Figure 1. Schematic of a cilium in the green alga Chlamydomonas .Cilia are anchored to the cell membrane by distal and sub-distal appendages (grey and green triangles) in the basal body. The Y-links (light blue) in the transition zone gate at the base controls the entry of proteins into the cilium. Proteins (brown hexagons), transmembrane proteins (brown) and other cargo are transported along microtubule tracks (grey cylinders) from the base of the cilium to the tip by kinesin motor proteins (blue) and an IFT train (yellow). The " 2807 3353 W2888053781.pdf 1 19 text 0.57132995 cargo proteins 3353 3368 W2888053781.pdf 1 20 caption 0.5540582 ¶ 3368 3369 W2888053781.pdf 1 21 text 0.6827802 are 3369 3373 W2888053781.pdf 1 22 caption 0.50728434 attach 3373 3380 W2888053781.pdf 1 23 text 0.5837281 ed 3380 3382 W2888053781.pdf 1 24 caption 0.6005852 directly 3382 3391 W2888053781.pdf 1 25 text 0.75109094 to the IFT train or via cargo adaptors (brown 3391 3437 W2888053781.pdf 1 26 caption 0.52790207 3437 3438 W2888053781.pdf 1 27 text 0.9773884 "ovals). At the tip, the trains release their cargo and break apart before remodeled IFT trains are returned to the base by dynein (pink). Kinesin, on the other hand, diffuses back to the base. Using a new imaging technique called PhotoGate, Chien et al. labeled certain proteins with fluorescent molecules, and then used a laser to ’photobleach’ most of them (represented here by fading) before they reached the tip. Since the photobleached molecules are dark, it is possible to follow the small number of labeled trains that remain fluorescent, and to better track their behavior at the tip of the cilium in order to study the remodeling of IFT trains." 3438 4105 W2888053781.pdf 1 28 separator 0.9945518 ¶ 4105 4107 W2888053781.pdf 1 29 bibliography 0.5764599 Kumar and King. eLife 4107 4129 W2888053781.pdf 1 30 paratext 0.6420503 2017 4129 4134 W2888053781.pdf 1 31 bibliography 0.54166174 ; 4134 4135 W2888053781.pdf 1 32 paratext 0.6440767 6 4135 4136 W2888053781.pdf 1 33 bibliography 0.591774 :e 4136 4138 W2888053781.pdf 1 34 paratext 0.65349233 32473 4138 4143 W2888053781.pdf 1 35 bibliography 0.6184999 . DOI: https://doi.org/10. 4143 4169 W2888053781.pdf 1 36 paratext 0.5656191 7554 4169 4173 W2888053781.pdf 1 37 bibliography 0.52488554 / 4173 4174 W2888053781.pdf 1 38 paratext 0.73793375 eLife.32473 2 of 3 4174 4192 W2888053781.pdf 1 39 title 0.97952855 Insight Intraflagellar transport Trainspotting in a cilium 4192 4250 W2888053781.pdf 1 0 paratext 0.9450605 "¶ Pamukkale Univ Muh Bilim Derg , 23(7), 899 -907, 2017 Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi Pamukkale University Journal of Engineering Sciences ¶ 899 ¶" 1 192 W4307652034.pdf 0 1 separator 0.9679127 ¶ 194 196 W4307652034.pdf 0 2 title 0.9904484 "Salisilik asit türevleri ile 2 -aminobenzotiyazol türevlerinin karışık ligandlı Cu(II) komplekslerinin sentezi ve karakterizasyonu" 196 330 W4307652034.pdf 0 3 separator 0.991742 ¶ 332 334 W4307652034.pdf 0 4 title 0.9666048 "Synthesis and characterization of mixed ligand Cu(II) complexes of salicylic acid derivatives with 2 -aminobenzotiyazol deriva tives" 334 470 W4307652034.pdf 0 5 separator 0.9891983 ¶ 472 474 W4307652034.pdf 0 6 contact 0.9916363 "Halil İLKİMEN1*, Cengiz YENİKAYA1 1Kimya Bölümü, Fen -Edebiyat Fakültesi, Dumlupınar Üniversitesi, Kütahya, Türkiye . halil.ilkimen@dpu.edu.tr , cengiz.yenikaya@dpu.edu.tr" 474 652 W4307652034.pdf 0 7 separator 0.944425 ¶ 654 656 W4307652034.pdf 0 8 paratext 0.97359806 "Geli ş Tarihi/ Received : 19.10.2016, Kabul Tarihi/ Accepted : 14.11.2016 * Yazışılan yazar/ Corresponding author doi: 10.5505 /pajes .2016.76735" 656 806 W4307652034.pdf 0 9 separator 0.832445 ¶ 808 810 W4307652034.pdf 0 10 paratext 0.70525205 Araştırma Makalesi/ Research Article 810 847 W4307652034.pdf 0 11 separator 0.8430705 ¶ ¶ 849 855 W4307652034.pdf 0 12 title 0.9770031 Öz Abstract 855 868 W4307652034.pdf 0 13 separator 0.9945059 ¶ 870 872 W4307652034.pdf 0 14 text 0.9989989 "Bu çalışmada, salisilik asit türevleri [salisilik asit (H 2sal) veya asetilsalisilik asit (Hasal )] ile 2 -aminobenzotiyazol türevlerinin [2-aminobenzotiyazol (abt) veya 2 -amino -6-klorobenzotiyazol (Clabt) veya 2 -amino -6-metilbenzotiyazol (Meabt)] karışık ligandlı Cu(II) geçiş metal kompleksleri sentezlenmiştir. Amorf halde elde edilen geçiş metal kom plekslerinin yapıları elementel analiz, ICP-OES, FT -IR, UV - Vis, termal analiz, manyetik duyarlılık ve molar iletkenlik sonuçları dikkate alınarak önerilmiştir. In this study, mixed ligand transition metal complexes of Cu( II) have been prepared between sal icylic acid derivatives [salicylic acid (H2sal) or acetylsalicylic acid (Hasal)] and 2 -aminobenzothiazole derivatives [2 -aminobenzothiazole (abt) or 2 -amino -6- chlorobenzothiazole (Clabt) or 2 -amino -6-methylbenzothiazole (Meabt)]. The structures of amorphou s metal complexes have been proposed by evaluating the data obtained from elemental analysis, ICP-OES, FT -IR, UV -Vis, thermal analysis, magnetic susceptibility and molar conductivity studies." 872 1994 W4307652034.pdf 0 15 separator 0.990317 ¶ 1996 1998 W4307652034.pdf 0 16 title 0.38593918 Anahtar kelimeler 1998 2016 W4307652034.pdf 0 17 text 0.4567905 ": Salisilik asit türevleri, 2 -aminobenzotiyazo l türevleri, Metal kompleksleri Keywords: Salicylic acid derivatives, 2 -aminobenzothiazole derivatives, Metal complexes" 2016 2194 W4307652034.pdf 0 18 separator 0.9968807 ¶ 2196 2198 W4307652034.pdf 0 19 title 0.98077774 1 Giriş 2198 2206 W4307652034.pdf 0 20 separator 0.9947573 ¶ 2208 2210 W4307652034.pdf 0 21 text 0.9984197 "Elektron verici oksijen atomları ( -COOH ve OH) bulunan salisilik asit ve türevleri (H2sal) ve proton vermiş formları (Hsal- ve sal2-) ile birçok çalışma yapılmaktadır. Bu çalışmalarda H2sal ve proton vermiş yapılarının yaygın olarak bir, iki, üç veya daha yüksek dişli olarak şelat oluşturdukları gözlenmiştir [1]. Literatürde salisilik asit [2 ]-[12] ve asetilsalisilik asit [3 ],[9],[13]-[19] ile organik asit veya bazların bulunduğu karışık ligandlı Cu(II) metal kompleksleri sentezlenmiştir. Bunlar antimikrobiyal, antiinflamatuar, antitümor, antiülser, antidiyabetik, antimütajen, süperoksit giderici ve radyoprotektif aktiviteye gibi biyolojik özelliklere sahiptir [2],[6]-[11],[20]-[23]." 2210 2943 W4307652034.pdf 0 22 separator 0.8174422 ¶ 2944 2946 W4307652034.pdf 0 23 text 0.9983793 "2-Aminobenzotiyazol türevlerinin antibakteriyel, antitümör, antiviral, antifungal, antihelmintik, anti -inflamatuar aktivite ve karbonik anhidraz inhibisyonu gibi biyolojik özellikleri bulunmaktadır [24]-[30]. 2-Aminobenzotiyazoller ile organik asitlerin karışık ligandlı bazı çalışmalar literatürde mevcuttur [30]-[41]. 2 -Aminobenzotiyazol türevleri bu kompleks bileşiklerinde metale N, S ve NH 2 atomlarından bağlandığı bilinmektedir [30]." 2946 3414 W4307652034.pdf 0 24 separator 0.9678055 ¶ 3416 3418 W4307652034.pdf 0 25 text 0.9984267 "Bu çalışmada, sal isilik asit ve türevleri [salisilik asit (H 2sal) ve asetilsalisilik asit (Hasal)] ile 2 -aminobenzotiyazol türevlerinin [2 -aminobenzotiyazol (abt), 2 -amino -6- klorobenzotiyazol (Clabt) ve 2 -amino -6-metilbenzotiyazol (Meabt)] karışık ligandlı Cu(II) geçiş met al kompleksleri sentezlenmiştir. Amorf halde elde edilen geçiş metal komplekslerinin yapıları elementel analiz, ICP-OES, FT -IR, UV - Vis, termal analiz, manyetik duyarlılık, molar iletkenlik, yük denkliği ve daha önceki çalışmalar ile önerilmiştir [4],[6],[8],[10],[12],[15],[17]-[19],[23]." 3418 4018 W4307652034.pdf 0 26 title 0.99152976 2 Materyal ve metot 4019 4039 W4307652034.pdf 0 27 separator 0.99561125 ¶ 4041 4043 W4307652034.pdf 0 28 title 0.96905357 2.1 Materyal 4043 4056 W4307652034.pdf 0 29 separator 0.9944074 ¶ 4058 4060 W4307652034.pdf 0 30 title 0.97223073 2.1.1 Kullanılan kimyasal maddeler 4060 4096 W4307652034.pdf 0 31 separator 0.99349415 ¶ 4098 4100 W4307652034.pdf 0 32 text 0.99790996 "Bu çalışmada kullanılan kimyasal maddeler Sigma Aldrich firmasından temin edilmiştir." 4100 4189 W4307652034.pdf 0 33 separator 0.9951933 ¶ 4191 4193 W4307652034.pdf 0 34 title 0.90959555 2.1.2 Metot 4193 4206 W4307652034.pdf 0 35 separator 0.99303436 ¶ 4208 4210 W4307652034.pdf 0 36 text 0.7893999 "Elementel Analiz Cihazı; LECO CHNS 932, ICP -OES Cihazı; Perkin Elmer 4300 O ptima, İnfrared Spektrometresi; BRUKER OPTICS VERTEX 70, TG -DTA cihazı; Pelkin Elmer, SII Exstar 6000 TG/DTA 6300, UV -Vis cihazı; SHIMADZU UV -2550 Spektrometresi, Manyetik Duyarlılık Cihazı; Sherwood Scientific Magway MSB MK1, Molar İletkenlik Cihazı; WTW" 4210 4561 W4307652034.pdf 0 37 table 0.48331252 4562 4563 W4307652034.pdf 0 38 text 0.72795045 "¶ Cond 315i/SET Model, Erime Noktası Tayin Cihazı; STUART SCIENTIFIC, Melting Point SMP3." 4563 4655 W4307652034.pdf 0 39 separator 0.99719983 ¶ 4657 4659 W4307652034.pdf 0 40 title 0.97731286 2.2 Metot 4659 4669 W4307652034.pdf 0 41 separator 0.99538326 ¶ 4671 4673 W4307652034.pdf 0 42 text 0.842509 "1 mmol Asit (0. 1381 g H 2sal veya 0.1802 Hasal), 1 mmol baz (0.1502 g abt veya 0.1847 g Clabt veya 0. 1642 g Meabt ) ve 0.5 mmol (0.099 g) Cu(CH 3COO) 2.H2O alınarak 30 mL su:etanolde (1:1) çözüldü. 72 sa at oda sıcaklığında karıştırıldıktan sonra kristallenmeye bırakıl mıştır. Çözelti ortamında çöken Cu(II) metal kompleksleri süzül müştür ve kurutul muştur . Elde edilen kompleks bileşiklerin bazı fiziksel özellikleri Tablo 1’de verilmiştir." 4673 5147 W4307652034.pdf 0 43 separator 0.9970832 ¶ 5149 5151 W4307652034.pdf 0 44 title 0.99207234 3 Bulgular ve tartışma 5151 5174 W4307652034.pdf 0 45 separator 0.99394727 ¶ 5176 5178 W4307652034.pdf 0 46 title 0.9905605 3.1 Elemental analiz ve ICP -OES sonuçları 5178 5221 W4307652034.pdf 0 47 separator 0.99526584 ¶ 5223 5225 W4307652034.pdf 0 48 text 0.99892783 "Cusalabt, CusalClabt, CusalMeabt, Cuasal, Cuasalabt, CuasalClabt ve CuasalMeabt metal komplekslerinin elementel analiz ve ICP -OES sonuçları Tablo 2’de verilmiştir. Deneysel olara k elde edilen değerler hem teorik elementel analiz değerleri ile hem de diğer spektroskopik çalışmalar sonucu ortaya konulan yapılar ile uyum içinde olduğu gözlenmiştir." 5225 5590 W4307652034.pdf 0 0 paratext 0.93662566 "Vol. 2, No. 2, Mei 2021 ISSN 2721 -4834" 0 42 W3167037696.pdf 4 1 separator 0.8488939 ¶ 44 46 W3167037696.pdf 4 2 paratext 0.94629985 206 Referensi 46 60 W3167037696.pdf 4 3 separator 0.9944347 ¶ 62 64 W3167037696.pdf 4 4 bibliography 0.9965083 "Budiana, A. , Muladi, M., & Putranto, H. (2019). Pengembangan Media Pembelajaran Digital Sistem Antena Berbasis React Pada Mata Pelajaran Penerapan Sistem Radio dan Televisi Kelas XI Teknik Audio Video di SMK Negeri 2 Singosari. Jurnal Edukasi Elektro, 3 (1). https://doi.org/10.21831/jee.v3i1.25895" 64 374 W3167037696.pdf 4 5 separator 0.9863161 ¶ 376 378 W3167037696.pdf 4 6 bibliography 0.98873824 "Nengsi, S . (201 5). Pengembangan Media Pembelajaran Animasi pada Materi Fotosintesis untuk Siswa Kelas VIII MTsN Koto Nan Gadang . BioCONCETTA , 1(2). https://doi.org/10.22202/bc.2015.v1i2.1504" 378 580 W3167037696.pdf 4 7 separator 0.9904611 ¶ 582 584 W3167037696.pdf 4 8 bibliography 0.99762255 "Ponza, P . J. R., Jampel, I. N., & Sudarma , I. K. (2018). Pengembangan Media Video Animasi pada Pembelajaran Siswa Kelas IV di Sekolah Dasar . Jurnal Edutech Universitas Pendidikan Ganesha, 6 (1)." 584 789 W3167037696.pdf 4 9 separator 0.9839089 ¶ 790 792 W3167037696.pdf 4 10 bibliography 0.90620524 https://ejournal.undiksha.ac.id/index.php/JEU/article/view/20257 792 857 W3167037696.pdf 4 0 paratext 0.99056375 Behav. Sci. 2022 ,12, 139 9 of 12 0 33 W4280616712.pdf 8 1 separator 0.9811626 ¶ 33 35 W4280616712.pdf 8 2 text 0.9770852 "considered the event as not being biased considered the event better organized than the ones that considered it biased." 35 157 W4280616712.pdf 8 3 separator 0.9823507 ¶ 157 159 W4280616712.pdf 8 4 text 0.9995692 "Hypothesis H5 tested if there is a significant difference in evaluation scores for the perceived quality of the content between groups with different bias perception. The distribution of scores were again not similar for all groups, as assessed by visual inspection of a boxplot. Median scores were statistically different between groups with different bias perception; H(2) = 23.641 and p< 0.001. After applying a pairwise comparisons using Dunn’s [ 18] procedure with a Bonferroni correction for multiple comparisons, statistically significant differences in evaluation scores were found between groups. Respondents that considered that the event was not biased (mean rank = 518.83) ( p< 0.001) and respondents that considered the event as being biased (mean rank = 519.96) had significantly higher scores than respondents that remained neutral (mean rank = 447.36) ( p= 0.001)." 159 1055 W4280616712.pdf 8 5 separator 0.9764104 ¶ 1055 1057 W4280616712.pdf 8 6 text 0.9996528 "The final hypothesis (H6) tested if there is a significant difference in evaluation scores for the lecturers between groups with different bias perception. The distribution of scores were assessed by visual inspection of a boxplot and are not similar for all groups. Me- dian scores were statistically different between groups with different bias perception; H(2) = 30.509 and p< 0.001. After applying the same post hoc test, statistically significant differences in evaluation scores were found between groups. Respondents that considered that the event was not biased (mean rank = 520.80) ( p< 0.001) and respondents that consid- ered the event as being biased (mean rank = 516.51) had significantly higher scores than respondents that remained neutral (mean rank = 439.20) ( p< 0.001)." 1057 1858 W4280616712.pdf 8 7 separator 0.9962537 ¶ 1858 1860 W4280616712.pdf 8 8 title 0.9881408 4. Discussion 1860 1874 W4280616712.pdf 8 9 separator 0.99588406 ¶ 1874 1876 W4280616712.pdf 8 10 text 0.99975103 "When assessing the results of our study, we see that they are contrary to the studies conducted by other researchers. This is due to the fact that the assumptions that were at the basis of students’ preference—reduction in costs and availability of time—are not validated in the case of professionals. As we see from the answers in the preferences of the organization of the events (Figure 1), professionals prefer days when they are off—meaning they are looking to develop themselves but outside the regular working hours. Moreover, when looking at the preferred type of event we notice that most of the respondents choose online events—such as webinars and case studies. The same results are shared by studies focusing on professionals [15,16]." 1876 2639 W4280616712.pdf 8 11 separator 0.97936136 ¶ 2639 2641 W4280616712.pdf 8 12 text 0.99972135 "Respondents’ rating of the material covered was independent of their belief about the bias of the course. This was not the case when looking at the perception of how much respondents learned. Respondents that considered the events as not being biased considered that they have learned much more than respondents that chose to remain neutral. This might indicate an unwillingness to express a negative opinion about the course. This phenomenon was also observed when asked about the quality of the content and of the lecturers, where people with a neutral opinion on bias rated both materials and lecturers significantly lower than people that expressed their (positive or negative) opinion on bias. Not surprisingly, respondents that considered the events as not being biased rated the overall quality of the event significantly higher than those that perceived the events as biased." 2641 3543 W4280616712.pdf 8 13 separator 0.98041666 ¶ 3543 3545 W4280616712.pdf 8 14 text 0.9996916 "The results of our study are contradictory to studies that had a focus on university education. Refs. [ 3,6,19] concluded that online education is not so well-perceived and could lead to fatigue. The results of [ 9] are also opposite compared with our current study which highlights the benefits of online courses." 3545 3865 W4280616712.pdf 8 15 separator 0.7899306 ¶ 3865 3867 W4280616712.pdf 8 16 text 0.9996655 "By focusing on the differences that other studies have pointed out, we can consider the quality of the materials [ 10,13]; the level of engagement [ 8,20] and the delivery method [ 7]." 3867 4054 W4280616712.pdf 8 17 separator 0.9606049 ¶ 4054 4056 W4280616712.pdf 8 18 text 0.9994906 "When assessing the overall quality of the programs, most of the literature that we analyzed presents different results than our study [ 1,3,7,8,12] with dissatisfaction ranging" 4056 4235 W4280616712.pdf 8 0 text 0.99867976 "clinical trials as a form of pai d work or work for health care ”(p. 117), particularly in con- texts where access to medical checks and basic health care is scarce or simply unavailable." 0 189 W1889354719.pdf 4 1 separator 0.99242246 ¶ 189 191 W1889354719.pdf 4 2 text 0.9996456 "Cooper and Waldby begin by reconstructing the history of human subject research in post-war America. Chapter 6 shows how clinical trials have moved from wartime excep- tionalism into the secluded space of the carceral system. Later, as prison-based experiments came under considerable critique, clinical res earch was moved into private medical centers and contract research organizations. The growth of the clinical trials industries notwithstanding, experimental labor has been kept away from the sphere of official labor relations –and bioethics has been a major force in maintaining this legal and discursive separation. From the 1990s onwards, newly liberalized countries and emerging economies have provided new experimental spaces for offshoring pharmaceutical production and clinical lab or (Chapter 7). In a sense, the crisis of pharmaceutical research was partially resolved by “contracting out ”experimental labor (and its embodied experimental risks) both institutionally and nationally." 191 1213 W1889354719.pdf 4 3 separator 0.9841856 ¶ 1213 1215 W1889354719.pdf 4 4 text 0.99967587 "Finally, the last chapter turns to a set of novel strategies and relations in drug innovation that walk hand in hand with a realignment of the clinic and its central place in the pharmaceutical business model. These strategies consist in opening up the con- fined clinical-experimental space towards a more distributed form of public experi- ment. On the one hand, patient groups in the US and elsewhere have increasingly claimed a right to assume experimental risks by accessing investigational drug prod- ucts. In this effort, some have formed alliances with pharmaceutical companies, or enjoy the support of libertarian think tanks and their deregulatory agendas. On the other hand, novel, mostly web-based strategies have sought to enroll the public in a collective effort of data generation facilitating some sort of open source model of bio- pharmaceutical innovation. Patients are asked to share and meticulously document their experiences with medication regimes, thus collecting tons of “post-marketing ” data valuable to the pharmaceutical industry. Thereby the public is being reconfigured as an “unwaged, highly skilled labor market ”(p. 218), further blurring the lines between clinic, market and society." 1215 2462 W1889354719.pdf 4 5 separator 0.9946075 ¶ 2462 2464 W1889354719.pdf 4 6 title 0.9932353 Discussion: A diagram of post-Fordist life, value and labor 2464 2524 W1889354719.pdf 4 7 separator 0.99094886 ¶ 2524 2526 W1889354719.pdf 4 8 text 0.9977214 "Clinical Labor offers detailed insights of how clinical trials, ART and regenerative medicine unfold aggressively in an expansive global post-Fordist economy. In a way, the argumentative structure of Clinical Labor resembles Eduardo Galeano ’s famous Open Veins of Latin America (Galeano 1998). Galeano ’s book details the brutal colonial history of Latin America, by reconstructing, chapter by chapter, each country ’s proper history of productive relations through the lenses of distinct commodities such as sugar cane, coffee or silver. While each separate chapter provides a compelling “stand alone ” analysis, the true force of Galeano ’s narrative unfolds only if these strands are articu- lated in an overall argument, thus revealing the overarching structures and patterns of political-economic domination that emerge as forceful and concerted system. Similarly, Clinical Labor provides a series of differentiated analyses, organized in separate chapters, that each deliver thorough analyses of different technologies (ART, clinical trials, etc.) articulated within particular socio-economic and cultural contexts (the US, China, Eastern Europe, etc.), thereby producing varied subjects (the oocyte vendor, the uninsured clinical research volunteer, etc.) and different forms of clinical labor (reproductive, regenerative,Haddad Life Sciences" 2526 3905 W1889354719.pdf 4 9 paratext 0.97732264 , Society and Policy (2015) 11:9 Page 5 of 8 3905 3950 W1889354719.pdf 4 0 paratext 0.58484787 FigUrE 2 | Flow chart of the study. 0 35 W2768973754.pdf 3 1 separator 0.7876148 ¶ 35 37 W2768973754.pdf 3 2 paratext 0.8059084 4Spaggiari et al. 37 55 W2768973754.pdf 3 3 separator 0.6736573 ¶ 55 57 W2768973754.pdf 3 4 title 0.9453394 Levothyroxine and Probiotics 57 86 W2768973754.pdf 3 5 separator 0.59613276 ¶ 86 88 W2768973754.pdf 3 6 paratext 0.954447 Frontiers in Endocrinology | www.frontiersin.org November 2017 | Volume 8 | Article 316 88 176 W2768973754.pdf 3 7 separator 0.9881345 ¶ 176 178 W2768973754.pdf 3 8 text 0.99817467 "with Chi-square or Fisher exact test. The changes after treatment were evaluated considering repeated variables, using Wilcoxon signed-rank test. The degree of correlation between ordinal vari- ables was studied using Spearman rho correlation test." 178 435 W2768973754.pdf 3 9 separator 0.80124474 ¶ 435 437 W2768973754.pdf 3 10 text 0.9935804 "In order to evaluate THs metabolism and pituitary feedback, fT3/fT 4, fT 3/TSH, and fT 4/TSH ratios were calculated. Moreover, hormonal measurements were adjusted for the anthropometrical available variables (BMI and BSA). Statistical analysis was performed using the “Statistical Package for the Social Sciences” software for Macintosh (version 21.0; SPSS Inc., Chicago, IL, USA). Statistical significance was considered significant when p < 0.05." 437 903 W2768973754.pdf 3 11 separator 0.9972074 ¶ 903 905 W2768973754.pdf 3 12 title 0.9906041 Ethical approval 905 922 W2768973754.pdf 3 13 separator 0.9935143 ¶ 922 924 W2768973754.pdf 3 14 text 0.99921024 "The Institutional Review Board of Modena (Comitato Etico di Modena) approved the study (code 184/13, approved on 12th November 2013)." 924 1061 W2768973754.pdf 3 15 separator 0.6147447 ¶ 1061 1063 W2768973754.pdf 3 16 text 0.9983586 "All procedures performed in studies involving human par - ticipants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or compara-ble ethical standards." 1063 1336 W2768973754.pdf 3 17 separator 0.9964168 ¶ 1336 1338 W2768973754.pdf 3 18 title 0.98832005 informed Consent 1338 1355 W2768973754.pdf 3 19 separator 0.9932782 ¶ 1355 1357 W2768973754.pdf 3 20 text 0.99890053 Written informed consent was obtained from all individual participants included in the study. 1357 1451 W2768973754.pdf 3 21 separator 0.9964261 ¶ 1451 1453 W2768973754.pdf 3 22 title 0.98736954 rESUl TS 1453 1462 W2768973754.pdf 3 23 separator 0.9938235 ¶ 1462 1464 W2768973754.pdf 3 24 text 0.99900186 "One hundred and twenty hypothyroid patients on LT 4 replace- ment therapy were screened and 80 patients were enrolled according to inclusion and exclusion criteria (Figure 2). Thirty- nine patients (48.8%) entered the study group and 41 (51.2%) the control group. Baseline characteristics of patients are shown in Table 1." 1464 1797 W2768973754.pdf 3 25 separator 0.8909576 ¶ 1797 1799 W2768973754.pdf 3 26 text 0.99965656 "At baseline, three male patients (3.75%) entered the study group while no male patients entered the control group. This gender disparity is in line with the known highest female inci-dence of primary hypothyroidism (1). Three patients (one male and two females) (7.69%) dropped out from the study group and six female patients (14.63%) dropped out from the control group (Figure 2). No adverse events were recorded in both groups and dropouts occurred for patients’ decision." 1799 2287 W2768973754.pdf 3 27 separator 0.9358846 ¶ 2287 2289 W2768973754.pdf 3 28 text 0.9994699 "No differences were observed between study and control group, considering anthropometrical variables (Table 1 ). Only heart rate was significantly higher in the control than in the study group ( p = 0.043)." 2289 2506 W2768973754.pdf 3 29 separator 0.9052725 ¶ 2506 2508 W2768973754.pdf 3 30 text 0.9997001 "The main cause of hypothyroidism was Hashimoto thyroidi- tis, occurring with similar incidence both in study and control group (71.8 and 73.2%, respectively; p = 0.916). Only two patients (4.88%) in the control group presented an iatrogenic hypothyroidism, due to total thyroidectomy or to radioiodine treatment. The majority of the patients was treated with branded LT 4 (97.5% in both groups; p = 0.971) and only the tablet formulation was used. Among branded LT 4, Eutirox® was the mostly taken (94.9% in the study vs. 90.2% in the control group; p = 0.432). The remaining patients were treated with Tirosint® (2.6% in the study group vs. 7.3% in the control group; p = 0.644)." 2508 3225 W2768973754.pdf 3 31 separator 0.79440767 ¶ 3225 3227 W2768973754.pdf 3 32 text 0.9982046 "The calculated compliance for probiotics ingestion was 79.2% in the study group." 3227 3311 W2768973754.pdf 3 33 separator 0.9969041 ¶ 3311 3313 W2768973754.pdf 3 34 title 0.9914008 Thyroid Hormones 3313 3330 W2768973754.pdf 3 35 separator 0.99618584 ¶ 3330 3332 W2768973754.pdf 3 36 text 0.9996161 "Thyroid-stimulating hormone, fT 3, fT 4 did not change between study and control group at each visit, as well as among visits in the two groups (Table 2 ). The lack of significance was confirmed after adjustment for BMI and BSA or considering hormonal ratios (fT 3/fT 4, fT 3/TSH, and fT 4/TSH)." 3332 3639 W2768973754.pdf 3 37 separator 0.8575492 ¶ 3639 3641 W2768973754.pdf 3 38 text 0.9996907 "In the control group, TSH was inversely related to fT 4 and fT3 (rho = −0.593, p < 0.001 and rho = −0.293, p = 0.004, respectively) while fT 4 and fT 3 were directly related each other (rho = 0.269, p = 0.004), as expected according to TH physiology." 3641 3905 W2768973754.pdf 3 39 separator 0.8860925 ¶ 3906 3908 W2768973754.pdf 3 40 text 0.99973774 "Unexpectedly, the correlation between TSH and fT 3 was lost after adjustment for age (p = 0.377) and BMI (p = 0.286). Similarly, TSH was inversely related to fT 4 (rho = −0.547, p < 0.001) in the study group, but their correlation to fT 3 was absent (p = 0.516 and p = 0.462, respectively). However, in both groups, the correlation was lost when each visit was considered separately, suggesting that the low number of cases evaluated in subgroup analyses impaired the statistical power." 3908 4413 W2768973754.pdf 3 41 separator 0.97489667 ¶ 4413 4415 W2768973754.pdf 3 42 text 0.99971986 "Regarding anthropometrical features at baseline, TSH was directly related to BMI (rho = 0.227, p = 0.047), but not to BSA (rho = 0.167, p = 0.146). Accordingly, fT 4 was inversely related to BMI (rho = −0.260, p = 0.023), while fT 3 did not correlate with any anthropometrical variable. Moreover, a direct cor - relation between TSH serum levels and systolic and diastolic pressures was found (rho = 0.282, p = 0.012 and rho = 0.227, p = 0.046, respectively). On the contrary, neither fT 4 nor fT 3 correlated with blood pressure. Similarly to what obtained for hormonal data, these relationships were lost considering fol- lowing visits. Moreover, heart rate did not correlate to THs at any time point." 4415 5152 W2768973754.pdf 3 43 separator 0.9862387 ¶ 5152 5154 W2768973754.pdf 3 44 text 0.9992056 "Evaluating the peripheral conversion of TH, the fT 3/fT 4 ratio was directly related to TSH at each visit in the control group, as expected for the known feedback mechanism. In the study group, this correlation was lost at visit 1 (rho = 0.287, p = 0.076), after" 5154 5429 W2768973754.pdf 3 0 paratext 0.82093316 Zbigniew Greń Wizerunek ateisty i jego miejsce na konfesyjnej mapie świata na Śląsku...303W 0 90 W2783333081.pdf 25 1 title 0.9034256 "izerunek ateisty i jego miejsce na konfesyjnej mapie świata na Śląsku Cieszyńskim" 90 174 W2783333081.pdf 25 2 separator 0.9931549 ¶ 174 176 W2783333081.pdf 25 3 title 0.9842345 Streszczenie 176 189 W2783333081.pdf 25 4 separator 0.99435294 ¶ 189 191 W2783333081.pdf 25 5 text 0.9941437 "Celem niniejszego artykułu jest stworzenie obrazu ateisty na podstawie źródeł historycznych i współczesnych. Historia pojęcia ateisty została opisana na podstawie prasy regionalnej, współczesny obraz – na podstawie wyników ankiet i dyskusji na tematy religijne na regionalnych stronach internetowych. " 191 503 W2783333081.pdf 25 6 separator 0.5013833 ¶ 503 504 W2783333081.pdf 25 7 text 0.9989421 "Analiza wykazała, że pojęcie ateisty jest traktowane jako pojęcie równorzędne z określeniami członków różnych kościołów. W wyniku badań przedstawiono nie tylko wizerunek ateisty, lecz także jego miejsce w systemie postrzegania różnic wyznaniowych." 504 761 W2783333081.pdf 25 8 separator 0.9945241 ¶ 761 763 W2783333081.pdf 25 9 text 0.3101879 Keywords: 763 775 W2783333081.pdf 25 10 table 0.2799327 a 775 776 W2783333081.pdf 25 11 text 0.32753655 theism; linguistic picture 776 803 W2783333081.pdf 25 12 table 0.3022167 of 803 806 W2783333081.pdf 25 13 text 0.31473055 the world; 806 817 W2783333081.pdf 25 14 table 0.32994446 stereotyp 817 827 W2783333081.pdf 25 15 text 0.34949547 es; mental maps; cultural history 827 860 W2783333081.pdf 25 16 separator 0.9932229 ¶ 860 862 W2783333081.pdf 25 17 table 0.29145396 Słowa 862 868 W2783333081.pdf 25 18 text 0.35208783 kluczowe: 868 878 W2783333081.pdf 25 19 table 0.40631863 a teizm; językowy obraz świata; stereotypy; mapy mentalne; historia kultury 879 955 W2783333081.pdf 25 20 separator 0.99070156 ¶ 955 957 W2783333081.pdf 25 21 contact 0.9922364 "Zbigniew Greń, Institute of Western and Southern Slavic Studies, Faculty of Polish Studies, University of Warsaw Correspondence: zgren@poczta.onet.pl" 957 1110 W2783333081.pdf 25 22 separator 0.8542956 ¶ 1110 1112 W2783333081.pdf 25 23 paratext 0.8791937 The article is financed within the National Centre for Science Opus Programme, no. 0 4101, Stosunki wyz 1112 1217 W2783333081.pdf 25 24 title 0.5021639 na 1217 1219 W2783333081.pdf 25 25 paratext 0.5283904 ­ 1219 1221 W2783333081.pdf 25 26 title 0.56698734 ¶ niowe w 1221 1231 W2783333081.pdf 25 27 paratext 0.5462063 językowym obraz 1231 1247 W2783333081.pdf 25 28 title 0.4822735 ie 1247 1249 W2783333081.pdf 25 29 paratext 0.73067826 "świata na Śląsku Cieszyńskim (Confessional relations in the linguistic picture of the world in Cieszyn Silesia )." 1249 1367 W2783333081.pdf 25 30 separator 0.9942883 ¶ 1367 1369 W2783333081.pdf 25 31 paratext 0.3826863 Competi 1369 1377 W2783333081.pdf 25 32 title 0.34975758 ng interests 1377 1389 W2783333081.pdf 25 33 paratext 0.4063773 : 1389 1390 W2783333081.pdf 25 34 text 0.5224407 The author has declared he has no competing interests. 1390 1445 W2783333081.pdf 25 0 paratext 0.587154 Automated transmission of hand water pumps in remote towns of Nigeria: Attaining a sustainable development project mana gement 0 126 W4252673581.pdf 2 1 separator 0.7917423 "¶ " 128 139 W4252673581.pdf 2 2 paratext 0.95912963 "¶ 15 Journal of Production and Industrial En gineering www.rame.org.in components. [8]" 139 445 W4252673581.pdf 2 3 text 0.91861755 "Eight key sustainable factors have been identified. These are: policy context, institutional arran gements, economic and financial issues, Community and social aspects, technology and the natural environment, supply of spare parts, maintenance and monitoring. These individual factors, together with guidance on sustainability, were explored extensively i n relation to financing, effective demand and management." 445 880 W4252673581.pdf 2 4 separator 0.987205 ¶ 882 884 W4252673581.pdf 2 5 text 0.9982465 "In combination with the experience of authors in this field, remote water supply service failures are due to two broad aspects with these observations in literature reviews :" 884 1065 W4252673581.pdf 2 6 separator 0.588238 ¶ 1066 1068 W4252673581.pdf 2 7 text 0.9957714 "Technical : Failure relating to the design and construction of the borehole, pump selection type and procedure and the lack of replacement parts . Managerial : These are failures linked to poor local administration and inefficient systems of support (financial, operational, and management) ." 1068 1383 W4252673581.pdf 2 8 separator 0.671308 ¶ 1384 1386 W4252673581.pdf 2 9 text 0.99919933 "It is evident that the cause of the failure in hand water pump could be technical or managerial. Analyzing the gaps of automation transmission from these prospects is imminent." 1386 1572 W4252673581.pdf 2 10 separator 0.9971043 ¶ 1574 1576 W4252673581.pdf 2 11 title 0.992741 D. Research Aim 1576 1592 W4252673581.pdf 2 12 separator 0.9949993 ¶ 1594 1596 W4252673581.pdf 2 13 text 0.99953014 "This research paper aimed to evaluate the ideal issu es related to transmission of hand water pump in remote towns of Nigeria and other nations and also analyze the causal issues of hand water pump failures with recommended solutions to enhance its efficiency and sustainability. This paper also tries to enha nce the relationship between the users and suppliers and how automation transmission can be passed across to the users." 1596 2047 W4252673581.pdf 2 14 separator 0.9969723 ¶ 2049 2051 W4252673581.pdf 2 15 title 0.99354106 E. Scope and Importance of Study 2051 2084 W4252673581.pdf 2 16 separator 0.9946207 ¶ 2086 2088 W4252673581.pdf 2 17 text 0.99817574 "The research analysis of 32 hand water pumps has scope in present and future. This research will eliminate all the problems associated with the present situation of automating hand washing pumps in remote communities of Nigeria. This research has high cost, high time consuming and will be an important government and nongovernmental tool in achieving their requ isite target towards automating the hand water pumps." 2088 2524 W4252673581.pdf 2 18 separator 0.99691534 ¶ 2526 2528 W4252673581.pdf 2 19 title 0.9919941 II. METHODOLOGY 2528 2545 W4252673581.pdf 2 20 separator 0.9959457 ¶ 2547 2549 W4252673581.pdf 2 21 text 0.99952585 "The research methodology used is the mixed methods, namely qualitative and quantitative methods of data collection and analysis. A mixed methods approach attempts to take advantage of t he similarities and differences in qualitative and quantitative methods [17]. The research population that was selected for the case study is are funded by International Organization for Migration located in Borno State. For the hand water pump users, from a sample of 70 borehole sites in IOM areas of operation, 32 boreholes were selected through multi -stage, systematic random sampling in 6 remote towns of Borno State which are: Bama, Gwoza, Chibok, Mafa, Damboa, Dikwa, Local Government Areas respectively. A questionnaire was administered to 73 users who source water from the 32 boreholes; 93% of them were regular members of the towns. The selection of hand water pump for the research were based on the relative distribution of the pump sizes. Information was collected from key informants from International Non -Governmental Organizations (INGOs), Government agencies, pump manufacturers and other stakeholders in the provision and use of hand pumps in Nigeria." 2549 3771 W4252673581.pdf 2 22 separator 0.9970163 ¶ 3773 3775 W4252673581.pdf 2 23 title 0.99335724 III. DISCUSSION AND RESULT 3775 3802 W4252673581.pdf 2 24 separator 0.9957154 ¶ 3804 3806 W4252673581.pdf 2 25 text 0.9996209 "The hand water pump usability and efficiency differ with various brands from suppliers. Also, some hand water pumps are frequently used more than others. This result to the breakdown and malfunctioning of major hand water pumps. Further research indicates that some of the boreholes have no sufficient water in it, thus making the hand water pump useless in the static position. The malfunctioning of the hand water pump is due to the design, operational and maintenance of the instrument. Other research and papers have supported this claim , as [8] asserts that the primary reason for hand pumps failure is insufficient attention to the operation and maintenance." 3806 4506 W4252673581.pdf 2 0 bibliography 0.99797887 "27. Ingvaldsen, R., Loeng, H., Ottersen, G. & Ådlandsvik Ingvaldsen, B. Climate variability in the Barents Sea during the 20th century with a focus on the1990s. ICES Mar. Sci. Symp. 219, 160 –168 (2003)." 0 205 W4386929387.pdf 10 1 separator 0.92052823 ¶ 205 207 W4386929387.pdf 10 2 bibliography 0.9977963 "28. Dickson, R. R. et al. The Arctic Ocean response to the North Atlantic Oscillation. J. Clim. 13, 2671 –2696 (2000)." 207 328 W4386929387.pdf 10 3 separator 0.83535624 ¶ 328 330 W4386929387.pdf 10 4 bibliography 0.9977374 "29. Serreze, M. C., Carse, F., Barry, R. G. & Rogers, J. C. Icelandic low cyclone activity: climatological features, linkages wit h the NAO, and relationships with recent changes in the northern hemisphere circulation. J. Clim. 10,4 5 3 –464 (1997)." 330 584 W4386929387.pdf 10 5 separator 0.8976532 ¶ 584 586 W4386929387.pdf 10 6 bibliography 0.99785805 "30. Deser, C., Walsh, J. E. & Timlin, M. S. Arctic sea ice variability in the context of recent atmospheric circulation trends. J. Clim. 13, 617 –633 (2000)." 586 746 W4386929387.pdf 10 7 separator 0.86075926 ¶ 746 748 W4386929387.pdf 10 8 bibliography 0.99794775 "31. Danilov, S., Sidorenko, D., Wang, Q. & Jung, T. The finite-volume sea ice–ocean model (FESOM2). Geosci. Model Dev. 10, 765 –789 (2017)." 748 889 W4386929387.pdf 10 9 separator 0.8393875 ¶ 889 891 W4386929387.pdf 10 10 bibliography 0.9979316 "32. Madonna, E., Hes, G., Li, C., Michel, C. & Siew, P. Y. F. Control of Barents Sea wintertime cyclone variability by large ‐scale atmospheric flow.Geophys. Res. 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Dyn. 49, 3141 –3157 (2017)." 1582 1742 W4386929387.pdf 10 17 separator 0.85765994 ¶ 1742 1744 W4386929387.pdf 10 18 bibliography 0.9976896 "36. Deser, C., Magnusdottir, G., Saravanan, R. & Phillips, A. The effects of North Atlantic SST and sea ice anomalies on the winter circulation in CCM3. Part II: direct and indirect components of the response. J. Clim. 17,8 7 7 –889 (2004)." 1744 1989 W4386929387.pdf 10 19 separator 0.9167861 ¶ 1989 1991 W4386929387.pdf 10 20 bibliography 0.9979427 "37. Screen, J. A., Simmonds, I., Deser, C. & Tomas, R. The atmospheric response to three decades of observed Arctic sea ice loss. J. Clim. 26, 1230 –1248 (2013)." 1991 2155 W4386929387.pdf 10 21 separator 0.85641146 ¶ 2155 2157 W4386929387.pdf 10 22 bibliography 0.99785364 "38. Cusinato, E., Rubino, A. & Zanchettin, D. Winter Euro ‐Atlantic climate modes: future scenarios from a CMIP6 multi ‐model ensemble. Geophys. Res. Lett. 48.https://doi.org/10.1029/2021GL094532 (2021)." 2157 2365 W4386929387.pdf 10 23 separator 0.90171933 ¶ 2365 2367 W4386929387.pdf 10 24 bibliography 0.99777937 "39. Ulbrich, U. & Christoph, M. A shift of the NAO and increasing storm track activity over Europe due to anthropogenic greenhouse gas forcing. Clim. Dyn. 15, 551 –559 (1999)." 2367 2547 W4386929387.pdf 10 25 separator 0.87226 ¶ 2547 2549 W4386929387.pdf 10 26 bibliography 0.9977923 "40. Branstator, G. & Selten, F. “Modes of variability ”and climate change. J. Clim. 22, 2639 –2658 (2009)." 2549 2658 W4386929387.pdf 10 27 separator 0.847662 ¶ 2658 2660 W4386929387.pdf 10 28 bibliography 0.9979734 "41. Deser, C., Phillips, A., Bourdette, V. & Teng, H. Uncertainty in climate change projections: the role of internal variability. Clim. Dyn. 38, 527 –546 (2012)." 2660 2825 W4386929387.pdf 10 29 separator 0.82162464 ¶ 2825 2827 W4386929387.pdf 10 30 bibliography 0.9977742 "42. Barnes, E. A. & Polvani, L. M. CMIP5 projections of Arctic ampli fication, of the North American/North Atlantic circulation, and of their relationship. J. Clim. 28, 5254 –5271 (2015)." 2827 3018 W4386929387.pdf 10 31 separator 0.86118925 ¶ 3018 3020 W4386929387.pdf 10 32 bibliography 0.9976704 "43. Luo, B. et al. Origins of Barents-Kara sea-ice interannual variability modulated by the Atlantic pathway of El Niño –Southern Oscillation. Nat. Commun. 14, 1–13 (2023)." 3020 3197 W4386929387.pdf 10 33 separator 0.926914 ¶ 3197 3199 W4386929387.pdf 10 34 bibliography 0.9978959 "44. Vessey, A. F., Hodges, K. I., Shaffrey, L. C. & Day, J. J. An inter-comparison of Arctic synoptic scale storms between four global reanalysis datasets. Clim. Dyn. 54, 2777 –2795 (2020)." 3199 3393 W4386929387.pdf 10 35 separator 0.9120666 ¶ 3393 3395 W4386929387.pdf 10 36 bibliography 0.9977667 "45. Stephenson, D. B., Pavan, V., Collins, M., Junge, M. M. & Quadrelli, R. North Atlantic Oscillation response to transient greenhouse gas forcing and theimpact on European winter climate: a CMIP2 multi-model assessment. Clim. Dyn. 27, 401 –420 (2006)." 3395 3653 W4386929387.pdf 10 37 separator 0.89636284 ¶ 3653 3655 W4386929387.pdf 10 38 bibliography 0.9976452 "46. Akperov, M. et al. Future projections of cyclone activity in the Arctic for the 21st century from regional climate models (Arctic-CORDEX). Glob. Planet Change 182, 103005 (2019)." 3655 3842 W4386929387.pdf 10 39 separator 0.91135263 ¶ 3842 3844 W4386929387.pdf 10 40 bibliography 0.99783653 "47. Valkonen, E., Cassano, J. & Cassano, E. Arctic cyclones and their interactions with the declining sea ice: a recent climatology. J. Geophys. Res. Atmos. 126, e2020JD034366 (2021)." 3844 4032 W4386929387.pdf 10 41 separator 0.93668365 ¶ 4032 4034 W4386929387.pdf 10 42 bibliography 0.997753 "48. Årthun, M., Eldevik, T., Smedsrud, L. H., Skagseth, Ø. & Ingvaldsen, R. B. 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Climatol. 26, 233 –249 (2006)." 5776 6034 W4386929387.pdf 10 59 separator 0.9295237 ¶ 6034 6036 W4386929387.pdf 10 60 bibliography 0.99775916 "58. KOBAYASHI, S. et al. The JRA-55 reanalysis: general speci fications and basic characteristics. J. Meteorol. Soc. Japn. Ser. II 93,5–48 (2015)." 6036 6184 W4386929387.pdf 10 61 separator 0.9600338 ¶ 6184 6186 W4386929387.pdf 10 62 bibliography 0.9968356 "59. TIBALDI, S. & MOLTENI, F. On the operational predictability of blocking. Tellus A 42, 343 –365 (1990)." 6186 6295 W4386929387.pdf 10 63 separator 0.9914604 ¶ 6295 6297 W4386929387.pdf 10 64 title 0.96643776 Acknowledgements 6297 6314 W4386929387.pdf 10 65 separator 0.98916376 ¶ 6314 6316 W4386929387.pdf 10 66 text 0.9930714 "We gratefully acknowledge the funding by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) through the Tra nsregional Collaborative Research Centre TRR-172 “ArctiC Ampli fication: Climate Relevant Atmospheric and SurfaCe Processes, and Feedback Mechanisms (AC)3”(grant 268020496). A.R. acknowledges funding by the Eur- opean Union ’s Horizon 2020 research and innovation framework program under Grant agreement no.101003590 (PolarRES project). M.I. was partially supported by BMBF through the project “Abrupt Climate Shifts and Extremes over Eurasia in Response to Arctic Sea Ice Change (ACE) ”under Grant 01LP2004A. We would li ke to thank Mirseid Akperov for providing the cyclone detection and tracking data. Furthermore, this work was supported by the North-German Supercomputing Alliance (HLRN). We are grateful to the HLRN super- computer staff, for providing the infrastructure allowing us to perform this research." 6316 7278 W4386929387.pdf 10 67 separator 0.99620557 ¶ 7278 7280 W4386929387.pdf 10 68 title 0.98193234 Author contributions 7280 7301 W4386929387.pdf 10 69 separator 0.9949235 ¶ 7301 7303 W4386929387.pdf 10 70 text 0.99930674 "F.O.H. designed the study, carried out the model experiments, and wrote the paper draft.L.A. analyzed the cyclone data. Q.W. and C.W. assisted in setting up and executing themodel simulations. M.I. carried out the atmospheric blocking analysis. T.K. and A.R., aswell as all other coauthors, assisted in interpreting and contextualizing the results. All coauthors were involved in reviewing and finalizing the manuscript." 7303 7725 W4386929387.pdf 10 71 separator 0.99547946 ¶ 7725 7727 W4386929387.pdf 10 72 title 0.883025 Funding 7727 7735 W4386929387.pdf 10 73 separator 0.9656143 ¶ 7735 7737 W4386929387.pdf 10 74 text 0.61844784 Open Access funding enabled and organized by Projekt DEAL. 7737 7796 W4386929387.pdf 10 75 separator 0.9906657 ¶ 7796 7798 W4386929387.pdf 10 76 title 0.9212249 Competing interests 7798 7818 W4386929387.pdf 10 77 separator 0.9389966 ¶ 7818 7820 W4386929387.pdf 10 78 text 0.6196267 The authors declare no competing interests. 7820 7864 W4386929387.pdf 10 79 separator 0.9868933 ¶ 7864 7866 W4386929387.pdf 10 80 title 0.8593194 Additional information 7866 7889 W4386929387.pdf 10 81 separator 0.95883936 ¶ 7889 7891 W4386929387.pdf 10 82 paratext 0.5871286 Supplementary information The online version contains supplementary 7891 7959 W4386929387.pdf 10 83 text 0.49214953 material 7959 7968 W4386929387.pdf 10 84 paratext 0.5560414 ¶ available at https://doi. 7968 7996 W4386929387.pdf 10 85 text 0.4736399 org 7996 7999 W4386929387.pdf 10 86 paratext 0.51545906 /10.1038/ 7999 8008 W4386929387.pdf 10 87 text 0.4681312 s 8008 8009 W4386929387.pdf 10 88 paratext 0.5783242 43247-023-00985-1 . 8009 8028 W4386929387.pdf 10 89 separator 0.94371337 ¶ 8028 8030 W4386929387.pdf 10 90 contact 0.6228883 Correspondence and requests for materials should be addressed to Finn Ole Heukamp. 8030 8113 W4386929387.pdf 10 91 separator 0.99050033 ¶ 8113 8115 W4386929387.pdf 10 92 paratext 0.48405564 Peer review information Communications Earth & Environment thanks Vida 8115 8186 W4386929387.pdf 10 93 contact 0.35461983 r Lien 8186 8192 W4386929387.pdf 10 94 paratext 0.519792 "and the other, anonymous, reviewer(s) for their contribution to the peer review of this work." 8192 8288 W4386929387.pdf 10 95 separator 0.59711814 ¶ 8288 8290 W4386929387.pdf 10 96 paratext 0.667817 Primary Handling Editors: 8290 8317 W4386929387.pdf 10 97 contact 0.36468452 Jennifer 8317 8325 W4386929387.pdf 10 98 paratext 0.39780816 Ve 8325 8328 W4386929387.pdf 10 99 contact 0.37915546 itch 8328 8332 W4386929387.pdf 10 100 paratext 0.451196 , He 8332 8336 W4386929387.pdf 10 101 contact 0.38086277 ike 8336 8339 W4386929387.pdf 10 102 paratext 0.40014163 Lang 8339 8344 W4386929387.pdf 10 103 contact 0.37867883 enberg 8344 8350 W4386929387.pdf 10 104 paratext 0.6900898 ". A peer review file is available." 8350 8385 W4386929387.pdf 10 105 separator 0.5580394 ¶ 8385 8387 W4386929387.pdf 10 106 paratext 0.83328325 Reprints and permission information is available at http://www.nature.com/reprints 8387 8470 W4386929387.pdf 10 107 separator 0.9452873 ¶ 8470 8472 W4386929387.pdf 10 108 paratext 0.51917696 "Publisher ’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional af filiations." 8472 8611 W4386929387.pdf 10 109 separator 0.96214 ¶ 8611 8613 W4386929387.pdf 10 110 paratext 0.95100015 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article ’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in thearticle ’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly fromthe copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/ ." 8613 9479 W4386929387.pdf 10 111 separator 0.5042931 9479 9480 W4386929387.pdf 10 112 paratext 0.97008353 "¶ © The Author(s) 2023COMMUNICATIONS EARTH & ENVIRONMENT | https://doi.org/10.1038/s43247-023-00985-1 ARTICLE COMMUNICATIONS EARTH & ENVIRONMENT | (2023) 4:324 | https://doi.org/10.1038/s43247-023-00985-1 | www.nature.com/commsenv 11" 9480 9725 W4386929387.pdf 10 0 paratext 0.99019295 Sustainability 2023 ,15, 16179 5 of 16 0 38 W4388858682.pdf 4 1 separator 0.9936495 ¶ 38 40 W4388858682.pdf 4 2 text 0.99970484 "Then, to produce the particleboard panel the cardoon particles were blended with the adhesive system in a 2500 W laboratory paddle mixer (iMAL 00G3446) for 5 min. The final mixture is placed in a mold/tray (a square aluminum container, with 220 22080 mm3dimensions), considering an adhesive/cardoon ratio of 0.8. The pressing was performed using a small computer-controlled scale/laboratorial press with 4000 W of power. Since it is necessary to preheat the press to 190C, in order to press the particleboard, two scenarios were considered with regard to the duration of the operation: (1) 65 min for summer conditions (summer scenario) and (2) 125 min for winter conditions (winter scenario). The hot plate pressing procedure itself involved pressing in two stages: (1) First, the cardoon/adhesive mixture in the mold was placed on the bottom plate and pressed to a 16 mm thickness for 60 s. (2) Then, the upper plate was raised to a 22 mm thickness and the particleboard was kept in the press for 240 s to allow the panel to expand. After pressing, stabilization follows, in which the particleboard remains at a temperature of 20 2C and a relative humidity of 65 5% until they reach a constant mass, as during the cooling period, they will lose some water. Finally, the panel is cut using a 1200 W squaring machine (MIDA SCE) for trimming the sides of the panel, which takes around 20 s, followed by the panel’s thickness calibration using a 6000 W sander (Boere Select-1100 kk) for sanding the panel for 1 min. The final product obtained in this way is the particleboard, with 220 22016 mm3dimensions, corresponding to this work’s functional unit. The particleboard main characteristics were determined according to the applicable European Standards, in particular the density [ 23], moisture content [ 24], internal bond strength [25] and thickness swelling [26]." 40 1956 W4388858682.pdf 4 3 separator 0.9770137 ¶ 1956 1958 W4388858682.pdf 4 4 text 0.9996901 "Although important for a more holistic understanding of the particleboard environ- mental impacts, the particleboard finishing, distribution, utilization and end-of-life stages were not considered in this study. Evaluating these final stages in the life cycle of parti- cleboard poses a number of challenges due to the lack of information and data published in the literature. For example, there is no single final application for the particleboard, as it can be used for different purposes in both the construction and furniture industries. It would therefore be necessary to simulate its many applications, and even in these usage scenarios, the variability and uncertainty would be enormous due to lack of user data and information. Also, such an analysis is beyond the scope of this study, which focuses on the environmental analysis of the panel production process, produced from agricultural waste and with an adhesive system of renewable origin, following a “cradle-to-gate” approach." 1958 2967 W4388858682.pdf 4 5 separator 0.99669945 ¶ 2967 2969 W4388858682.pdf 4 6 title 0.99376976 2.2. Case Study Description: Particleboard Formulation 2969 3024 W4388858682.pdf 4 7 separator 0.995803 ¶ 3024 3026 W4388858682.pdf 4 8 text 0.9995104 "As described above, this work considers a specific case study, which aims to evaluate the life cycle of a particleboard produced from cardoon fibers with a potato starch/chitosan adhesive, based on the experimental work described by Monteiro et al. [ 13]. The adhesive consists of the following components: potato starch, distilled water, chitosan and propionic acid. The best initial formulation for the particleboard, according to Monteiro et al. [ 13] has the following components and characteristics:" 3026 3539 W4388858682.pdf 4 9 separator 0.7689691 ¶ 3539 3541 W4388858682.pdf 4 10 table 0.95941275 "Starch/cardoon ratio (dry basis): 0.80; Chitosan/starch ratio: 0.05; Water/starch ratio: 1.75; Cardoon mass (wet basis): 0.113 kg; Initial moisture in the cardoon: 13%; Chitosan in the final solution: 5 wt%; Propionic acid solution: 6 wt%." 3543 3806 W4388858682.pdf 4 11 separator 0.9183824 ¶ 3806 3808 W4388858682.pdf 4 12 text 0.9990658 "Based on these data, mass balances were carried out to calculate the quantities of each raw material entering the system under study, required for the life cycle inventory." 3808 3983 W4388858682.pdf 4 13 separator 0.8858014 ¶ 3983 3985 W4388858682.pdf 4 14 text 0.9989976 "The particleboards produced using this formulation had a final density, after stabilization, trimming and calibration, of 323 kg m" 3985 4118 W4388858682.pdf 4 0 paratext 0.9886284 Remote Sens. 2024 ,16, 1591 3 of 15 0 35 W4396518644.pdf 2 1 separator 0.99365103 ¶ 35 37 W4396518644.pdf 2 2 text 0.9989792 "which are one of the main hubs of the “West–East Power Transmission” project. As one of them, Baihetan Hydropower Station, which is the second largest in the world in terms of power generation capacity, is located in Qiaojia County, Yunnan Province and Nanning County, Sichuan Province, in the lower reaches of the Jinsha River (as shown in Figure 1)." 37 395 W4396518644.pdf 2 3 separator 0.94202805 ¶ 395 397 W4396518644.pdf 2 4 text 0.99941355 "The Baihetan reservoir region experiences a subtropical dry/warm river valley climate, with an average annual temperature that varies from 12◦C to 20◦C. The region undergoes significant rainfall between May and October, contributing to approximately 90% of the annual precipitation in contrast to the clear and dry weather prevalent from November to April with minimal rainfall [ 28]. The area is primarily composed of limestone and basalt rocks, with basalt being structurally fragile and prone to fracturing. Factors, including precipitation, gravity, and water level changes due to reservoir operations, contribute to the frequent occurrence of geological hazards like landslides and debris flows, which has a significant impact on reservoir water level changes and the stability of the dam." 397 1208 W4396518644.pdf 2 5 separator 0.9870075 ¶ 1208 1210 W4396518644.pdf 2 6 paratext 0.98554873 Remote Sens. 2024 , 16, x FOR PEER REVIEW 3 of 16 1210 1260 W4396518644.pdf 2 7 separator 0.94723576 ¶ ¶ 1261 1267 W4396518644.pdf 2 8 title 0.9932845 2. Study Area and Datasets 1268 1295 W4396518644.pdf 2 9 separator 0.99476516 ¶ 1296 1298 W4396518644.pdf 2 10 title 0.9804976 2.1. Study Area 1298 1314 W4396518644.pdf 2 11 separator 0.9935757 ¶ 1315 1317 W4396518644.pdf 2 12 text 0.9996616 "Jinsha River originates from the Tanggula Mountains in Qinghai Province, China. It is dominated by steep alpine banks and deep valleys and, as a result, forms a typical al- pine-canyon terrain. The large elevation drop (about 3300 m), rugged terrain, and abun- dant water resources have resulted in the co nstruction of more than 20 hydropower sta- tions, which are one of the main hubs of th e “West–East Power Transmission” project. As one of them, Baihetan Hydropower Station, which is the second largest in the world in terms of power generation capacity, is located in Qiaojia County, Yunnan Province and Nanning County, Sichuan Province, in the lower reaches of the Jinsha River (as shown in Figure 1). The Baihetan reservoir region ex periences a subtropical dry/warm river valley climate, with an average annual temper ature that varies from 12 °C to 20 °C. The region undergoes signi ficant rainfall between May and October, contributing to approximately 90% of the annual precipitation in contrast to the clear and dry weather prevalent from November to April with minimal rainfall [28]. The area is primarily composed of lime- stone and basalt rocks, with basalt being structurally fragile and prone to fracturing. Fac-tors, including precipitation, gravity, and wa ter level changes due to reservoir operations, contribute to the frequent occurrence of geol ogical hazards like landslides and debris flows, which has a signi ficant impact on reservoir water level changes and the stability of the dam." 1317 2870 W4396518644.pdf 2 13 separator 0.9906785 ¶ ¶ 2871 2877 W4396518644.pdf 2 14 caption 0.9839223 Figure 1. Study area overview. 2877 2908 W4396518644.pdf 2 15 separator 0.99079823 ¶ 2909 2911 W4396518644.pdf 2 16 title 0.9920799 2.2. Datasets 2911 2925 W4396518644.pdf 2 17 separator 0.99535674 ¶ 2926 2928 W4396518644.pdf 2 18 text 0.9986858 "This study utilized SAR data from two satellite missions collected from four orbits, including L-band data from both the ascending and descending orbits of ALOS-2 and C- band data from both the ascending and descending orbits of Sentinel-1. The datasets con-sisted of 11 ascending images, 9 ascending images from ALOS-2, and 35 ascending images, 32 descending images from Sentinel-1. Figure 2 shows the temporal distribution of these images. Figure 1 displays the coverage area of the SAR images, while Table 1 presents the main parameters. For this study, the data on vegetation coverage originated from the " 2928 3553 W4396518644.pdf 2 19 separator 0.91448027 ¶ 3553 3554 W4396518644.pdf 2 20 caption 0.98080695 Figure 1. Study area overview. 3554 3585 W4396518644.pdf 2 21 separator 0.9913638 ¶ 3585 3587 W4396518644.pdf 2 22 title 0.98851234 2.2. Datasets 3587 3601 W4396518644.pdf 2 23 separator 0.9944782 ¶ 3601 3603 W4396518644.pdf 2 24 text 0.9993636 "This study utilized SAR data from two satellite missions collected from four orbits, including L-band data from both the ascending and descending orbits of ALOS-2 and C-band data from both the ascending and descending orbits of Sentinel-1. The datasets consisted of 11 ascending images, 9 ascending images from ALOS-2, and 35 ascending images, 32 descending images from Sentinel-1. Figure 2 shows the temporal distribution of these images. Figure 1 displays the coverage area of the SAR images, while Table 1 presents the main parameters. For this study, the data on vegetation coverage originated from the Landsat 8 satellite. The Landsat panchromatic image of the study area was obtained in August 2022." 3603 4325 W4396518644.pdf 2 0 paratext 0.9885595 Minerals 2020 ,10, 20 4 of 15 0 29 W2998216593.pdf 3 1 separator 0.9928367 ¶ 29 31 W2998216593.pdf 3 2 text 0.9965673 "structure of the nodules indicated that Ni, Cu, and Co are bound to the (MnO 6) octahedra of Mn-oxide [ 11]. No isolated Ni-, Co-, or Cu-bearing crystalline structures were observed in the XRD pattern." 31 237 W2998216593.pdf 3 3 separator 0.986885 ¶ 237 239 W2998216593.pdf 3 4 paratext 0.98503673 Minerals 2020 , 10, x FOR PEER REVIEW 4 of 15 239 285 W2998216593.pdf 3 5 separator 0.99325967 ¶ 286 288 W2998216593.pdf 3 6 text 0.95479417 "Mn-oxide [11]. No isolated Ni-, Co-, or Cu-bearing crystalline structures were observed in the XRD pattern." 288 400 W2998216593.pdf 3 7 separator 0.9908025 ¶ 401 403 W2998216593.pdf 3 8 table 0.984867 "20 40 60 80100200300400500600♣ ♣ ♣ ♣♦− Quartz ∇− Feldspar ♦∇Intensity(counts) Two-Theat(deg)∇♦10 Å phyllomanganate ♣−" 403 534 W2998216593.pdf 3 9 separator 0.90707695 ¶ ¶ 534 540 W2998216593.pdf 3 10 caption 0.99482715 Figure 1. X-ray diffraction (XRD) pattern of polymetallic nodules. 540 607 W2998216593.pdf 3 11 separator 0.9943368 ¶ 609 611 W2998216593.pdf 3 12 title 0.99198794 3.2. Thermodynamic Analysis 611 639 W2998216593.pdf 3 13 separator 0.9967052 ¶ 640 642 W2998216593.pdf 3 14 text 0.99871695 "A selective reduction process is based on the difference in reduction temperatures of several main metal oxides. Selective reduction of polymeta llic oxides can be achieved by controlling the temperature interval. The oxides of Ni, Co, Cu, an d Fe were reduced to form metallic states, and MnO 2 was reduced to MnO." 642 967 W2998216593.pdf 3 15 separator 0.9706034 ¶ 968 970 W2998216593.pdf 3 16 text 0.9761264 The reaction formula of metal oxides reduced by carbon is as follows: 970 1040 W2998216593.pdf 3 17 separator 0.9232661 ¶ 1041 1043 W2998216593.pdf 3 18 math 0.8554477 "MeO + C = Me + CO (1) 2MeO + C = 2Me + CO 2 (2) where Me is Ni, Co, Cu, Fe, Mn, etc." 1043 1134 W2998216593.pdf 3 19 separator 0.953187 ¶ 1135 1137 W2998216593.pdf 3 20 text 0.98314494 "The standard Gibbs free energy changes of the main Equations (3)–(12) in the solid-state metalized reduction process were calculated using HSC 6.0 software." 1137 1297 W2998216593.pdf 3 21 separator 0.9889817 ¶ 1298 1300 W2998216593.pdf 3 22 math 0.9439662 "NiO (s) + C (s) = Ni (s) + CO (g) ΔGө = [121094 − 171.67 T] J·mol−1 T0 = 705.38 K (3) CoO (s) + C (s) = Co (s)+CO (g) ΔGө = [131084 − 164.27 T] J·mol−1 T0 = 797.96 K (4) CuO (s) + C (s) = Cu (s) + CO (g) ΔGө = [37829 − 170.96 T] J·mol−1 T0 = 221.27 K (5) 3Fe 2O3 (s) + C (s) = 2Fe 3O4 (s) + CO (g) ΔGө = [237700 − 222.00 T] J·mol−1 T0 = 1070.72 K (6) Fe3O4 (s) + C (s) = 3FeO (s) + CO (g) ΔGө = [262350 − 179.70 T] J·mol−1 T0 = 1459.93 K (7) FeO (s) + C (s) = Fe (s) + CO (g) ΔGө = [147763 − 150.06 T] J·mol−1 T0 = 984.68 K (8)" 1300 1888 W2998216593.pdf 3 23 separator 0.9888059 ¶ 1889 1891 W2998216593.pdf 3 24 caption 0.9949627 Figure 1. X-ray di raction (XRD) pattern of polymetallic nodules. 1891 1958 W2998216593.pdf 3 25 separator 0.99537957 ¶ 1958 1960 W2998216593.pdf 3 26 title 0.99178535 3.2. Thermodynamic Analysis 1960 1988 W2998216593.pdf 3 27 separator 0.9963933 ¶ 1988 1990 W2998216593.pdf 3 28 text 0.9986419 "A selective reduction process is based on the di erence in reduction temperatures of several main metal oxides. Selective reduction of polymetallic oxides can be achieved by controlling the temperature interval. The oxides of Ni, Co, Cu, and Fe were reduced to form metallic states, and MnO 2was reduced to MnO." 1990 2309 W2998216593.pdf 3 29 separator 0.9683267 ¶ 2309 2311 W2998216593.pdf 3 30 text 0.931123 The reaction formula of metal oxides reduced by carbon is as follows: 2311 2381 W2998216593.pdf 3 31 separator 0.8713099 ¶ 2381 2383 W2998216593.pdf 3 32 math 0.8361851 "MeO +C=Me+CO (1) 2MeO +C=2Me+CO 2 (2) where Me is Ni, Co, Cu, Fe, Mn, etc." 2383 2462 W2998216593.pdf 3 33 separator 0.9006342 ¶ 2462 2464 W2998216593.pdf 3 34 text 0.97008514 "The standard Gibbs free energy changes of the main Equations (3)–(12) in the solid-state metalized reduction process were calculated using HSC 6.0 software." 2464 2623 W2998216593.pdf 3 35 separator 0.99240947 ¶ 2623 2625 W2998216593.pdf 3 36 math 0.934718 "NiO (s) +C (s) =Ni (s) +CO (g) DG/uni04E9=[121,094" 2625 2678 W2998216593.pdf 3 0 paratext 0.98390144 "50 www.scielo.br/rsbmtINTRODUCTIONRevista da Sociedade Brasileira de Medicina Tropical 46(1):50-54, Jan-Feb, 2013 http://dx.doi.org/10.1590/0037-86821738 2013" 0 162 W2045820004.pdf 0 1 title 0.77986073 Major Article 162 176 W2045820004.pdf 0 2 separator 0.98590815 ¶ 176 178 W2045820004.pdf 0 3 contact 0.99009687 "Address to . Dr. Miguel Tanús Jorge. Serviço de Controle de Infecção Hospitalar/ HC/UFU. Av. Pará 1720, Campus Umuarama, Umuarama. 38400-902 Uberlândia, MG, Brasil.Phone: 55 34 3218-2224; Fax: 55 34 3218-2199e-mail: miglind@ufu.br" 178 415 W2045820004.pdf 0 4 separator 0.907563 ¶ 415 417 W2045820004.pdf 0 5 paratext 0.9463125 "Received in 20/08/2012 Accepted in 11/01/2013" 417 465 W2045820004.pdf 0 6 title 0.98870635 "Impact of an intervention in the use of sequential antibiotic therapy in a Brazilian university hospital" 465 572 W2045820004.pdf 0 7 separator 0.9944414 ¶ 572 574 W2045820004.pdf 0 8 bibliography 0.4707947 R 574 576 W2045820004.pdf 0 9 contact 0.50350356 aquel Melo Rodrigues 576 596 W2045820004.pdf 0 10 bibliography 0.4859284 [1], 596 600 W2045820004.pdf 0 11 contact 0.597958 Astrídia Marília 600 617 W2045820004.pdf 0 12 bibliography 0.5114524 de Souza 617 626 W2045820004.pdf 0 13 contact 0.55083305 Fontes 626 633 W2045820004.pdf 0 14 bibliography 0.5598803 [1],[2], 633 641 W2045820004.pdf 0 15 contact 0.58883923 Orlando César Mantese 641 663 W2045820004.pdf 0 16 bibliography 0.44706345 [1], 663 669 W2045820004.pdf 0 17 contact 0.41525728 ¶ 669 670 W2045820004.pdf 0 18 bibliography 0.5010958 Rena 670 675 W2045820004.pdf 0 19 contact 0.5014695 ta 675 677 W2045820004.pdf 0 20 bibliography 0.56351835 Souza Martins[1] and Miguel Tanús Jorge[1],[2] 677 724 W2045820004.pdf 0 21 separator 0.72849286 ¶ 724 726 W2045820004.pdf 0 22 bibliography 0.54280096 [1]. Programa de Pós- 726 748 W2045820004.pdf 0 23 contact 0.47992444 Gradua 748 754 W2045820004.pdf 0 24 bibliography 0.50303996 ção em Ci 754 763 W2045820004.pdf 0 25 contact 0.48976713 ências 763 769 W2045820004.pdf 0 26 bibliography 0.5121635 da Saúde, 769 780 W2045820004.pdf 0 27 contact 0.49074697 Facul 780 785 W2045820004.pdf 0 28 bibliography 0.5062046 dade de Medicina, Universidade Federal de 785 826 W2045820004.pdf 0 29 contact 0.50881153 Uberlândia 826 837 W2045820004.pdf 0 30 bibliography 0.5007431 . Uber 837 843 W2045820004.pdf 0 31 contact 0.52405334 lândia 843 849 W2045820004.pdf 0 32 bibliography 0.5107668 , MG. [2]. 849 860 W2045820004.pdf 0 33 contact 0.51540226 Serviço 860 867 W2045820004.pdf 0 34 bibliography 0.5576726 de Controle de Infecção Hospitalar, Hospital de Clínicas, Universidade Federal de Uberlândia. Uberlândia, MG. 867 977 W2045820004.pdf 0 35 separator 0.99514675 ¶ 977 979 W2045820004.pdf 0 36 title 0.985911 ABSTRACT 979 988 W2045820004.pdf 0 37 separator 0.99492097 ¶ 988 990 W2045820004.pdf 0 38 text 0.9995611 "Introduction: Sequential antibiotic therapy (SAT) is safe and economical. However, the unnecessary use of intravenous (IV) administration usually occurs. The objective of this work was to get to know the effectiveness of an intervention to implement the SAT in a teaching hospital in Brazil. Methods: This was a prospective and interventional study, historically controlled, and was conducted in the Hospital de Clínicas , Universidade Federal de Uberlândia, State of Minas Gerais, Brazil, a high complexity teaching hospital having 503 beds. In each of the periods, from 04/04/05 to 07/20/05 (pre-intervention) and from 09/24/07 to 12/20/07 (intervention), 117 patients were evaluated. After the pre-intervention period, guidelines were developed which were implemented during the intervention period along with educational measures and a reminder system added to the patients’ prescription. Results: In the pre-intervention and intervention periods, the IV antibiotics were used as treatment for a average time of 14.8 and 11.8 days, respectively. Ceftriaxone was the antibiotic most prescribed in both periods (23.4% and 21.6% respectively). Starting from the first prescription of antibiotics, the average length of hospitalization time was 21.8 and 17.5 days, respectively. The SAT occurred only in 4 and 5 courses of treatment, respectively, and 12.8% and 18.8% of the patients died in the respective periods. Conclusions: Under the presented conditions, the evaluated intervention strategy is ineffective in promoting the exchange of the antibiotic administration from IV to oral treatment (SAT)." 990 2615 W2045820004.pdf 0 39 separator 0.9943348 ¶ 2615 2617 W2045820004.pdf 0 40 title 0.5860587 Keywords: Antibiotics 2617 2639 W2045820004.pdf 0 41 text 0.52093613 . Anti 2639 2645 W2045820004.pdf 0 42 title 0.5457629 microbial 2645 2654 W2045820004.pdf 0 43 text 0.5006618 . Antibiotic policy. Switch 2654 2681 W2045820004.pdf 0 44 title 0.6061901 therapy 2681 2689 W2045820004.pdf 0 45 separator 0.98930866 ¶ 2689 2691 W2045820004.pdf 0 46 text 0.97964007 "In many developing countries, the availability and the use of antibiotics are poorly controlled, resulting in high rates of microbial resistance 1. Brazil has a Unified Health System (SUS), which provides for all actions and health services which are gratuitously provided by the governments. SUS is applied to the entire Brazilian population 2, and the health authorities are concerned about the proper use of antibiotics3." 2691 3132 W2045820004.pdf 0 47 separator 0.5209428 3132 3133 W2045820004.pdf 0 48 text 0.98945194 "¶ Serious bacterial infections should be, and are traditionally treated with IV antibiotics. However, after clinical improvement, the oral treatment (OT) can be used. Besides, the prolonged and unnecessary use of IV , although not desirable, usually occurs 4. One of the data used to evaluate the use of antibiotics in hospitals described by the European Surveillance of Antimicrobial Consumption (ESAC) is the proportion of oral versus parenteral use. (ESAC moved to European Centre for Disease Prevention and Control – ECDC - in 2011 and is now named ESAC-Net) 5. Sequential antibiotic therapy (SAT) refers to the exchange from the parenteral route to the oral treatment as soon as the patient is clinically stable. Clinical and laboratory criteria are suggested so as to identify the patients who are sufficiently stable to enable therapy change 6. It is already clear that SAT is safe, and economical, and that it improves the quality of healthcare4,7." 3133 4111 W2045820004.pdf 0 49 separator 0.7969116 ¶ 4111 4113 W2045820004.pdf 0 50 text 0.99094814 "Oral formulations are cheaper then IV ones, leading to a reduction in the following: time of preparation and administration, work of nursing staff, drug waste and length of hospitalization. The OT is also easy to continue at home 8-10. Moreover, the reduction of the hospital stay and the length of catheter use, due to SAT, may lead to a reduction in hospital infection incidence 8,11,12." 4113 4513 W2045820004.pdf 0 51 separator 0.73366284 ¶ 4513 4515 W2045820004.pdf 0 52 text 0.9858895 "As a consequence of the increasing economic pressure, it becomes necessary to control hospital costs which are deeply influenced by the use of intravenous drugs, thus the SAT strategy is being more and more implemented. Therefore, studies are considered necessary in order to reduce the use of IV antibiotics in the treatment of hospitalized patients 13. Previous studies with SAT differ as to the characteristics of the intervention, of the hospital, of the infectious syndromes and of the antibiotics tested 6,14-17. In this context, the purpose of this present study was to discover the frequency of SAT practice and, especially, an effective strategy to reduce the use of IV antibiotics by the implementation of the SAT in a teaching hospital in Brazil." 4515 5288 W2045820004.pdf 0 53 separator 0.99688613 ¶ 5288 5290 W2045820004.pdf 0 54 title 0.99001485 METHODS 5290 5298 W2045820004.pdf 0 55 separator 0.9953041 ¶ 5298 5300 W2045820004.pdf 0 56 text 0.99733245 "This prospective, historically controlled, interventional study was conducted at the Clinical Hospital of the Federal University of Uberlândia (HCU). The HCU is a public teaching" 5300 5482 W2045820004.pdf 0 0 paratext 0.9558841 BULLETIN OF RSMU 2, 2018 VESTNIKRGMU.RU | |METHOD SURGERY77 0 65 W2883663628.pdf 4 1 text 0.9889515 "lesser pain, in some cases the pain was gone completely and knee functions returned in full, which had positive effect on patient satisfaction." 65 211 W2883663628.pdf 4 2 separator 0.51592064 ¶ 211 213 W2883663628.pdf 4 3 text 0.9860764 "Today, collagen matrix is the most advanced widely available biological material used to repair cartilage tissue, a material that positively affects stem cell differentiation and chondrogenesis. We believe this operation is the proper choice for patients with 3rd stage of Koenig's disease (full-thickness defects of hyaline cartilage, no damage to subchondral bone)." 213 592 W2883663628.pdf 4 4 separator 0.97370666 ¶ 593 595 W2883663628.pdf 4 5 text 0.9911723 "Prerequisites: healthy hyaline cartilage surrounding the defect, viable subchondral bone and unchanged mechanical axis of the lower limb. Contraindications: multiple cartilage defects, including ""kissing lesions""; widespread knee osteoarthritis; systemic autoimmune diseases; knee joint instability caused by ligament and meniscus injury; valgus or varus leg deformations that call for corrective surgery; allergic reactions to collagen." 595 1041 W2883663628.pdf 4 6 separator 0.98063445 ¶ 1042 1044 W2883663628.pdf 4 7 text 0.99927163 "Special attention should be paid to the state of the subchondral bone: expressed sclerosis there indicates its non-viability. We believe the non-viable part of the bone should be sanitated up to the healthy, bleeding layers, and the defect remedied through osteoplasty. Lack of pinpoint bleeding after subchondral bone tunneling signals of its non-viability, which should alert the surgeon. In such cases, implantation of a collagen matrix without osteoplasty is fruitless." 1044 1521 W2883663628.pdf 4 8 separator 0.9965334 ¶ 1521 1523 W2883663628.pdf 4 9 text 0.90961283 "The list below presents our recommendations based on the analysis of long-term outcomes of AMIC technique application to our patients." 1523 1661 W2883663628.pdf 4 10 separator 0.53979 ¶ 1662 1664 W2883663628.pdf 4 11 text 0.9887036 "– A mandatory prerequisite for collagen matrix implantation is healthy and stable subchondral bone. – Deep (over 5 mm) local damage to subchondral bone calls for osteoplasty on the osteochondral defect.– Simultaneous osteoplasty (on the osteochondral defect, using a biocomposite bone) and matrix implantation is unpromising. – Physical activity level of the patient should be factored in when planning the surgery. Unfortunately, AMIC and sport of records are incompatible." 1664 2155 W2883663628.pdf 4 12 separator 0.99565184 ¶ 2155 2157 W2883663628.pdf 4 13 title 0.9869368 CONCLUSION 2157 2168 W2883663628.pdf 4 14 separator 0.9958981 ¶ 2168 2170 W2883663628.pdf 4 15 text 0.9992676 "Having analyzed the outcomes of treatment done in our hospital, as well as available literature and technical capabilities, we optimized the algorithm for surgical treatment of patients suffering from knee osteochondritis desiccans and arrived at a number of conclusions: 1) patients with open physes should undergo removal of the non-viable cartilaginous plate, sanation of the osteochondral defect and subchondral bone tunneling;2) AMIC technique is the optimal choice for cases where there is a full-thickness local cartilage damage and undamaged subchondral bone; 3) local osteochondral defects measuring less than 10 cm2 may best be treated with ""mosaic"" osteochondral autotransplantation; 4) local osteochondral defects measuring 10–15 cm2 call for combined ""mosaic"" osteochondral transplantation." 2170 3001 W2883663628.pdf 4 16 separator 0.9860846 ¶ 3001 3003 W2883663628.pdf 4 17 text 0.99926805 "In conclusion, we would like to note that through the objective analysis of errors and complications we have managed to change the stereotypes around local cartilage and osteochondral femoral condyle defects treatment tactics, sort out a number of unpromising technologies and improve the surgery procedures. Nevertheless, surgery on knee osteochondritis desiccans is still is subject containing many controversial issues." 3003 3429 W2883663628.pdf 4 18 separator 0.9953437 ¶ 3429 3431 W2883663628.pdf 4 19 bibliography 0.9978989 "1. Anders S, W iech O, Schaumburger J, et al. Autologus Matrix induced chondrogenesis (AMIC) for focal chondal defects of the knee — first results. J Bone Joint Surg Br. 2009; 91 (Suppl.1): 83–7." 3431 3636 W2883663628.pdf 4 20 separator 0.97110665 ¶ 3637 3639 W2883663628.pdf 4 21 bibliography 0.9976281 "2. Malanin DA, Pisar ev VB, Novochadov VV. Vosstanovlenie povregdeniy chryasha v kolennom sustave. Eksperimental’nye i klinicheskie aspekty. Volgograd: Volgogradskoe nauchnoe izdatel’stvo; 2010. 455 с." 3639 3851 W2883663628.pdf 4 22 separator 0.97208184 ¶ 3851 3853 W2883663628.pdf 4 23 bibliography 0.9977408 "3. Alfor d JW, Cole BJ. Cartilage restoration, part 1: basic science, historical perspective, patient evaluation and treatment options. Am J Sports Med. 2005; 33 (2): 295–306." 3853 4036 W2883663628.pdf 4 24 separator 0.97017515 ¶ 4036 4038 W2883663628.pdf 4 25 bibliography 0.9978148 "4. Solheim E, Hegna J, Inderhaug E, Oyen J, Harlem T , Strand T. Results at 10–14 years after microfracture treatment of articular cartilage defects in the knee. Knee Surg Sports Traumatol Arthroscop. 2016; 24 (5): 1587–93." 4038 4265 W2883663628.pdf 4 26 separator 0.96216804 ¶ 4265 4267 W2883663628.pdf 4 27 bibliography 0.9958897 "5. Xing L, Jiang Y , Gui J, Lu Y, et al. Microfracture combined with osteochondral paste implantation was more effective than microfracture alone for full-thickness cartilage repair. Knee Surg Sports Traumatol Arthroscop. 2013; 21 (8): 1770–76." 4267 4519 W2883663628.pdf 4 28 separator 0.9711324 ¶ 4519 4521 W2883663628.pdf 4 29 bibliography 0.99653906 "6. Laupattarakasem W, Laopaiboon M, Laupattarakasem P , Sumananont C. Arthroscopic debridement for knee osteoarthritis (Review). Cochrane Database Syst Rev. 2008; Issue 1. Art. No.: CD005118. DOI: 10.1002/14651858.CD005118.pub2." 4521 4756 W2883663628.pdf 4 30 separator 0.97179574 ¶ 4756 4758 W2883663628.pdf 4 31 bibliography 0.99542725 "7. Stadnikov AA, Kavalerskiy GM, Arhipov SV, Pavlov VP , Makarov SA, Makarov MA, i dr. Novye metody hirurgicheskogo lecheniya defectov gialinovogo chryasha kolennogo sustava u bol’nyh s gonartrozom. Nauchno-practicheskaya revmatologiya. 2009; 3: 90–3." 4758 5021 W2883663628.pdf 4 32 separator 0.9684212 ¶ 5022 5024 W2883663628.pdf 4 33 bibliography 0.99503887 "8. T ratting S, Ba-Ssalamah A, Pinker K, Plank C, Vescei V, Marlovits S. Magnetic Resonance Imaging. 2005; 23 (7): 779–87." 5024 5153 W2883663628.pdf 4 34 separator 0.94844556 ¶ 5153 5155 W2883663628.pdf 4 35 bibliography 0.99778265 "9. Koval’chul VN. Klassifikaciya povr egdeniy chryasha kolennogo sustava. Luchevaya diagnostica, luchevaya terapiya. 2012; 1: 99–106." 5155 5293 W2883663628.pdf 4 36 separator 0.9722148 ¶ 5294 5296 W2883663628.pdf 4 37 bibliography 0.9977399 "10. Golovaha ML, Loskutov AE, Egorov VF. Korrelyacia dannyh magnitno-rezonansnoy tomografii i artroscopii pri travmaticheskih povregdeniyah kolennogo sustava. Praktikyushemu vrachu. 2011; 12 (2): 99–105." 5296 5504 W2883663628.pdf 4 38 separator 0.9769139 ¶ 5504 5506 W2883663628.pdf 4 39 bibliography 0.9906723 "11. Lazishvili GD, Zatikyan VR, Shukyur -Zadeh ER, Kornaev AS, Akmataliev KI, Danilov MA. Actual direction of chondroplasty. Bulletin of Russian State Medical University. 2013; 3: 13–17." 5506 5703 W2883663628.pdf 4 40 separator 0.96603596 ¶ 5704 5706 W2883663628.pdf 4 41 bibliography 0.9976538 "12. Malyshev EE, Kor olyov SB, Pavlov DV, Kuvshinov SG. Osteochondral autoplasty of the extensive post-traumatic defect of the proximal tibia. Modern technologies in medicine. 2014; 6 (2): 142–7." 5706 5908 W2883663628.pdf 4 42 separator 0.9761777 ¶ 5908 5910 W2883663628.pdf 4 43 bibliography 0.9896311 "13. Kotel’nikov GP , Larcev YV, Kudashev DS, Zuev-Ratnikov SD, Shorin IS. Mosaicplasty in the treatment of patients with destructive-dystrophic and post-traumatic lesions hyaline cartilage in the knee joint — experimental and clinical aspects. Fundamental research. 2013; 9: 252–5." 5910 6199 W2883663628.pdf 4 44 separator 0.9744725 ¶ 6200 6202 W2883663628.pdf 4 45 bibliography 0.9853474 "14. Zakir ova AR. Artroskopicheskoe lechenie hrjashevyh defectov kolennogo sustava. М.: 2010." 6202 6302 W2883663628.pdf 4 46 separator 0.9349645 ¶ 6302 6304 W2883663628.pdf 4 47 bibliography 0.9978502 "15. Caldwell PE, Shelton WR. Indications for allografts. Orthop Сlin North Am. 2005; 36 (4): 459–67." 6304 6409 W2883663628.pdf 4 48 separator 0.94150925 ¶ 6409 6411 W2883663628.pdf 4 49 bibliography 0.99780625 "16. Sadlik B, W iewiorski M. Implantation of a collagen matrix for an AMIC repair during dry arthroscopy. Knee Surg Sports Traumatol Arthrosc. 2015; 23: 2349–52." 6411 6577 W2883663628.pdf 4 50 separator 0.9601756 ¶ 6577 6579 W2883663628.pdf 4 51 bibliography 0.9958188 "17. Gille J, Schuseil E, Wimmer J, et al. Mid-term results of autologus matrix-indused chondrogenesis for treatment of focal cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc. 2010; 18: 1456. https://doi.org/10.1007/s00167-010-1042-3." 6579 6845 W2883663628.pdf 4 52 separator 0.9698008 ¶ 6846 6848 W2883663628.pdf 4 53 bibliography 0.99746144 "18. Pascar ella A, Ciatti R, Pascarella F, et al. Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique. References" 6848 7005 W2883663628.pdf 4 0 caption 0.9586689 Figure 1 TRiaDS Framework .Clarkson et al.Implementation Science 2010, 5:57 0 75 W2149919639.pdf 4 1 separator 0.79796165 ¶ 75 77 W2149919639.pdf 4 2 paratext 0.97337073 http://www.implementationscience.com/content/5/1/57Page 5 of 10 77 141 W2149919639.pdf 4 0 paratext 0.8348165 "¶ ( 396 (ً على استراتيجيات الإمام علي)عليه السلام" 1 54 W4361016437.pdf 7 1 separator 0.8853274 ¶ 54 56 W4361016437.pdf 7 2 title 0.9708559 تحليل المحتوى من الوصايا بناء 56 83 W4361016437.pdf 7 3 separator 0.800319 ¶ 83 85 W4361016437.pdf 7 4 paratext 0.7224954 "........... ........ )" 85 113 W4361016437.pdf 7 5 separator 0.9612565 ¶ ¶ 115 121 W4361016437.pdf 7 6 title 0.91162455 ٢-يالميزات الأخلاقية واص ٢ 121 145 W4361016437.pdf 7 7 separator 0.68175954 ¶ 146 148 W4361016437.pdf 7 8 text 0.66565955 258 259 W4361016437.pdf 7 9 separator 0.53673375 ¶ 259 260 W4361016437.pdf 7 10 text 0.98571974 "،  ل   ، وا ا ول اى ا ن أن  ت ا  ، وق اك واا () :" 261 505 W4361016437.pdf 7 11 separator 0.7654021 ¶ 505 507 W4361016437.pdf 7 12 text 0.4778355 ١ن: 507 512 W4361016437.pdf 7 13 math 0.43834832 - 512 513 W4361016437.pdf 7 14 text 0.5378128  ر و أن 513 536 W4361016437.pdf 7 15 math 0.44243285 536 537 W4361016437.pdf 7 16 text 0.49267197  ا أ 537 547 W4361016437.pdf 7 17 math 0.45245403 548 549 W4361016437.pdf 7 18 text 0.50549304 ؛ ا وا اا 549 574 W4361016437.pdf 7 19 separator 0.50085455 ¶ 574 576 W4361016437.pdf 7 20 math 0.7941271 "M ¶ x ¶ y ¶ z ¶ { ¶ | ¶ } ¶ ~ ¶ ¶ L /)ط۴۴  اث أ .( ()   ا ۵٩   م ا () :»َ ()  ا  ِ، و   ا  ِ،" 576 801 W4361016437.pdf 7 21 text 0.49031052  801 803 W4361016437.pdf 7 22 math 0.545457 و 805 808 W4361016437.pdf 7 23 text 0.531346  دَ 808 813 W4361016437.pdf 7 24 math 0.5513611 813 814 W4361016437.pdf 7 25 text 0.5097198  إ 814 817 W4361016437.pdf 7 26 math 0.47835243 818 819 W4361016437.pdf 7 27 text 0.538451 ¶ 819 820 W4361016437.pdf 7 28 math 0.53206855  820 822 W4361016437.pdf 7 29 text 0.49523836 ا 822 823 W4361016437.pdf 7 30 math 0.55935454  ِ ِ و 823 835 W4361016437.pdf 7 31 text 0.50519925 ا « 835 843 W4361016437.pdf 7 32 math 0.6395595 ،)د ۶٢١،۶٨٣١ (. 843 863 W4361016437.pdf 7 33 separator 0.9904928 ¶ 920 922 W4361016437.pdf 7 34 text 0.54443836 ٢-  922 929 W4361016437.pdf 7 35 title 0.62434185 ل ا  929 938 W4361016437.pdf 7 36 text 0.96398973 " :  ل  إ   ()    م أنء أو ا  ا»أ   سُ ا إم  ِ وا  ُأ  ْ   ط ِْ و أإ  ْ إ    و أمْ  ْ ْَ   ِ َ و إ أ ْ   ... ْ « ر، ا)م۶٣١ (." 938 1196 W4361016437.pdf 7 37 separator 0.84145963 ¶ 1213 1215 W4361016437.pdf 7 38 text 0.9373223 "، ن آ و  ل  ذ  ث ا  روح ا   أم س:  ل م ،»أ   سُا ا ُِَ ا  ِْُ ح ٍٍ وا ِُ اُْ وا ْِ َ َ  ْ ْ رُو  ا  ر ... « ر، ا)م۶٣١ (." 1216 1471 W4361016437.pdf 7 39 separator 0.99122685 ¶ 1490 1492 W4361016437.pdf 7 40 text 0.94901234 "٣-  ا    :  أو وان وا أن   ا  أم ا   ، و  ة  ي ا  ت : »أ   سُ ا إم  ْ ُْَ   ُ ا ا  ا  و  ما  ءُ ُأدّ و أ  ُ إ   ْ  أدّتِ وا  ءُ ْ إ َ ُَْَ ...«" 1492 1802 W4361016437.pdf 7 41 bibliography 0.54439974 ) 1802 1806 W4361016437.pdf 7 42 text 0.51683986 ر 1806 1807 W4361016437.pdf 7 43 bibliography 0.48742887  1807 1810 W4361016437.pdf 7 44 text 0.45828348 ا 1810 1814 W4361016437.pdf 7 45 bibliography 0.55465907 "،م ٨۴٢ (." 1814 1825 W4361016437.pdf 7 46 separator 0.9474426 ¶ 1930 1932 W4361016437.pdf 7 47 text 0.89103943 "و  ل  ا۵٠١ : : » إم     ا  إ  َّُ ِ  أ غُ: ر  ا  ِ،دُ و ا  ا  ا  ِ ... ،" 1932 2074 W4361016437.pdf 7 48 bibliography 0.56809855 "« ) ر ا،م ۶٣١ (." 2074 2100 W4361016437.pdf 7 49 separator 0.9956701 ¶ 2221 2223 W4361016437.pdf 7 50 title 0.9643474 ٢-ةيو مواعظ الأخلاق حةيأسباب لقبول نص ٣ 2223 2261 W4361016437.pdf 7 51 separator 0.9923006 ¶ ¶ 2262 2357 W4361016437.pdf 7 52 text 0.98541194 "ل ا ب أ  ا   وا وا  ا  ا   ا و    قل ط  ا   :" 2357 2480 W4361016437.pdf 7 53 separator 0.9438666 ¶ 2482 2484 W4361016437.pdf 7 54 text 0.6908974 ١- د س أمم ءس ا اآن ا ا ، :ن 2484 2544 W4361016437.pdf 7 55 separator 0.45446765 ¶ 2544 2546 W4361016437.pdf 7 56 math 0.65354776 "M ¶ μ ¶ ¶ ¶" 2547 2571 W4361016437.pdf 7 57 table 0.48008814 ̧ 2572 2573 W4361016437.pdf 7 58 math 0.5978207 "¶ 1o ¶" 2573 2588 W4361016437.pdf 7 59 table 0.5320086 » 2588 2590 W4361016437.pdf 7 60 math 0.52695936 ¶ ¶ 2590 2596 W4361016437.pdf 7 61 table 0.5275644 1⁄4 2596 2599 W4361016437.pdf 7 62 math 0.4858619 ¶ 2599 2600 W4361016437.pdf 7 63 table 0.6939346 "¶ 1⁄2 ¶ 3⁄4 ¶ ¿ ¶ À ¶ Á ¶ à ¶ Ä ¶ Å ¶ Æ ¶ Ç ¶ L " 2602 2692 W4361016437.pdf 7 64 math 0.3137553 ¶ 2692 2693 W4361016437.pdf 7 65 separator 0.85786116 ¶ 2695 2697 W4361016437.pdf 7 66 paratext 0.34972152 ) 2697 2700 W4361016437.pdf 7 67 bibliography 0.29051974  2700 2701 W4361016437.pdf 7 68 paratext 0.32200748 ه 2701 2702 W4361016437.pdf 7 69 bibliography 0.37747723 / ا  ٩۶٢ ( 2702 2717 W4361016437.pdf 7 0 paratext 0.9885289 Molecules 2024 ,29, 498 15 of 21 0 32 W4391045572.pdf 14 1 separator 0.9944054 ¶ 32 34 W4391045572.pdf 14 2 text 0.99115926 "especially the walnut have been intensively studied for their individual, multiple biological activities both for human health and phytosanitary properties. This review particularly highlights the antimicrobial activity on some pathogenic mi- croorganisms that manifest their action on plant, leguminous, and fruit crops, which raises the hypothesis of the separate or combined use of walnut and elderberry extracts to prevent or stop the proliferation of pathogens. From this perspective, we have already initiated a research series with the aim of verifying the combined action of the phytochemicals of the two species, in order to obtain additional benefits in anticipation of a synergistic effect." 34 750 W4391045572.pdf 14 3 separator 0.99585557 ¶ 750 752 W4391045572.pdf 14 4 bibliography 0.9800991 "Author Contributions: Conceptualization, A.-L.F., I.-L.I. and O.-I.P .; writing—original draft prepara- tion, A.S.-B. and I.-A. S,.; writing—review and editing, I.-L.I. and O.-I.P .; visualization, A.S.-B., I.-A. S,., I.-L.I. and O.-I.P .; supervision, A.-L.F.; project administration, A.-L.F.; funding acquisition, A.-L.F. All authors have read and agreed to the published version of the manuscript." 752 1159 W4391045572.pdf 14 5 separator 0.98531836 ¶ 1159 1161 W4391045572.pdf 14 6 paratext 0.73334116 Funding: This study received no external funding. 1161 1211 W4391045572.pdf 14 7 separator 0.9805227 ¶ 1211 1213 W4391045572.pdf 14 8 paratext 0.5835501 Institutional Review Board Statement: Not applicable. 1213 1267 W4391045572.pdf 14 9 separator 0.9342636 ¶ 1267 1269 W4391045572.pdf 14 10 paratext 0.5152786 Informed Consent Statement: Not applicable. 1269 1313 W4391045572.pdf 14 11 separator 0.9154235 ¶ 1313 1315 W4391045572.pdf 14 12 paratext 0.4222474 Data 1315 1320 W4391045572.pdf 14 13 bibliography 0.43066543 Availability 1320 1333 W4391045572.pdf 14 14 paratext 0.4423028 Statement 1333 1343 W4391045572.pdf 14 15 bibliography 0.41660058 : Not 1343 1348 W4391045572.pdf 14 16 paratext 0.42177165 applicable. 1348 1360 W4391045572.pdf 14 17 separator 0.9025456 ¶ 1360 1362 W4391045572.pdf 14 18 bibliography 0.43299264 1362 1363 W4391045572.pdf 14 19 paratext 0.52399707 Conflicts of Interest: The authors declare no conflicts of interest. 1363 1431 W4391045572.pdf 14 20 separator 0.9927131 ¶ 1431 1433 W4391045572.pdf 14 21 title 0.66364014 References 1433 1444 W4391045572.pdf 14 22 separator 0.9845319 ¶ 1444 1446 W4391045572.pdf 14 23 bibliography 0.9880634 "1. 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Available online: https://www.indexbox.io/search/production-walnut-romania/ (accessed on 5 October 2023). 2654 2763 W4391045572.pdf 14 36 separator 0.9601642 ¶ 2763 2765 W4391045572.pdf 14 37 bibliography 0.9969244 "9. Institutul Na t,ional de Statistic ă.Produc t,ia Vegetal ăla Principalele Culturi în Anul 2021 ; Editura Institutului Na t,ional de Statistic ă: Bucharest, Romania, 2022." 2765 2941 W4391045572.pdf 14 38 separator 0.942856 ¶ 2941 2943 W4391045572.pdf 14 39 bibliography 0.9979411 "10. Popa, R.-G.; B ălăcescu, A.; Popescu, L.G. Organic walnut cultivation in intensive and super-intensive system—Sustainable investment. Case study: Gorj County, Romania. Sustainability 2023 ,15, 1244. [CrossRef]" 2943 3159 W4391045572.pdf 14 40 separator 0.89488256 ¶ 3159 3161 W4391045572.pdf 14 41 bibliography 0.99801356 11. Lozan, A.; Arndt, C. Report on the Status of Organic Agriculture and Industry in Romania ; EkoConnect: Desden, Germany, 2022. 3161 3291 W4391045572.pdf 14 42 separator 0.8879292 ¶ 3291 3293 W4391045572.pdf 14 43 bibliography 0.9974802 "12. Mocanu, M.L.; Amariei, S. Elderberries—A source of bioactive compounds with antiviral action. Plants 2022 ,11, 740. [CrossRef] [PubMed]" 3293 3435 W4391045572.pdf 14 44 separator 0.9580983 ¶ 3435 3437 W4391045572.pdf 14 45 bibliography 0.99767995 "13. Pascariu, O.-E.; Israel-Roming, F. Bioactive compounds from elderberry: Extraction, health benefits, and food applications. Processes 2022 ,10, 2288. [CrossRef]" 3437 3604 W4391045572.pdf 14 46 separator 0.9605384 ¶ 3604 3606 W4391045572.pdf 14 47 bibliography 0.99465775 "14. Has,, I.M.; Teleky, B.-E.; Szabo, K.; Simon, E.; Ranga, F.; Diaconeasa, Z.M.; Purza, A.L.; Vodnar, D.-C.; Tit, D.M.; Ni t,escu, M. Bioactive potential of elderberry ( Sambucus nigra L.): Antioxidant, antimicrobial activity, bioaccessibility and prebiotic potential. Molecules 2023 ,28, 3099. [CrossRef] [PubMed]" 3606 3926 W4391045572.pdf 14 48 separator 0.97037756 ¶ 3926 3928 W4391045572.pdf 14 49 bibliography 0.9980268 "15. Zhan, Y.; Ma, M.; Chen, Z.; Ma, A.; Li, S.; Xia, J.; Jia, Y. A review on extracts, chemical composition and product development of walnut Diaphragma juglandis fructus. Foods 2023 ,12, 3379. [CrossRef]" 3928 4135 W4391045572.pdf 14 50 separator 0.89405274 ¶ 4135 4137 W4391045572.pdf 14 51 bibliography 0.9979258 "16. Sharma, M.; Sharma, M.; Sharma, M. A comprehensive review on ethnobotanical, medicinal and nutritional potential of walnut (Juglans regia L.).Proc. Indian Natl. Sci. Acad. 2022 ,88, 601–616. [CrossRef]" 4137 4345 W4391045572.pdf 14 52 separator 0.9475229 ¶ 4345 4347 W4391045572.pdf 14 53 bibliography 0.997956 "17. Bourais, I.; Elmarrkechy, S.; Taha, D.; Mourabit, Y.; Bouyahya, A.; El Yadini, M.; Machich, O.; El Hajjaji, S.; El Boury, H.; Dakka, N.; et al. A review on medicinal uses, nutritional value, and antimicrobial, antioxidant, anti-inflammatory, antidiabetic, and anticancer potential related to bioactive compounds of J. regia .Food Rev. Int. 2023 ,39, 6199–6249. [CrossRef]" 4347 4727 W4391045572.pdf 14 54 separator 0.930146 ¶ 4727 4729 W4391045572.pdf 14 55 bibliography 0.9980063 "18. Sidor, A.; Gramza-Michałowska, A. Advanced research on the antioxidant and health benefit of elderberry ( Sambucus nigra ) in food—A review. J. Funct. Food. 2015 ,18, 941–958. [CrossRef]" 4729 4922 W4391045572.pdf 14 56 separator 0.93797624 ¶ 4922 4924 W4391045572.pdf 14 57 bibliography 0.99805564 "19. Du, H.; Li, C.; Wen, Y.; Tu, Y.; Zhong, Y.; Yuan, Z.; Li, Y.; Liang, B. Secondary metabolites from pericarp of Juglans regia .Biochem. Syst. Ecol. 2014 ,54, 88–91. [CrossRef]" 4924 5105 W4391045572.pdf 14 0 paratext 0.9720371 "4 Volume 109 | Number 9/10 September/October 2013South African Journal of Science http://www.sajs.co.za" 0 111 W2150962617.pdf 3 1 title 0.9901654 Table 3: Student responses to questions about their university environment 111 186 W2150962617.pdf 3 2 separator 0.9804126 ¶ 186 188 W2150962617.pdf 3 3 table 0.9695465 "Survey question Stream 1 (%)Stream 2 (%) Where are you living while at university? Residence 73†63† Off-campus accommodation 19 24 At home 5 9 How are you paying for your studies? Financial aid 45†44† Family 36 41 Bursary 9 9 Other 2 2" 188 451 W2150962617.pdf 3 4 separator 0.60488427 ¶ 451 453 W2150962617.pdf 3 5 text 0.51579916 453 454 W2150962617.pdf 3 6 table 0.5126179 † 454 455 W2150962617.pdf 3 7 text 0.5733449 Totals less than 100% indicate a null student response to the question. 455 526 W2150962617.pdf 3 8 separator 0.99525464 ¶ 526 528 W2150962617.pdf 3 9 title 0.8496321 What was your reason for choosing to study physics? 528 580 W2150962617.pdf 3 10 separator 0.97251976 ¶ 580 582 W2150962617.pdf 3 11 text 0.99957585 "In Stream 1, approximately 40% of the students are doing Physics as part of an Engineering degree. Their responses indicate that they enjoyed the subject matter and found that it helps them better understand their Applied Mathematics curriculum. Approximately 40% of the students in Stream 1 intended to major in Physics. The remaining 20% of respondents in Stream 1 are taking Physics as a gateway to other career paths such as Medical or Engineering degrees. In Stream 2, 90% of the students are studying Physics because it is a prerequisite for their modules in life sciences or agricultural sciences. The remaining 10% are studying Physics as a gateway to other fields of study." 582 1292 W2150962617.pdf 3 12 separator 0.99677426 ¶ 1292 1294 W2150962617.pdf 3 13 title 0.96646595 "What were the main adjustments between physics in school and at university?" 1294 1373 W2150962617.pdf 3 14 separator 0.9785007 ¶ 1373 1375 W2150962617.pdf 3 15 text 0.99960846 "A high number (40%) of students cited an increase in the workload as the main adjustment between school and university physics. About 10% found it difficult to cope with university physics mainly because of the language barrier. English-only lectures made communication difficult as the students were not used to a solely English environment. Most of the 10% were fearful of asking questions in class because of their poor English and thus their misconceptions remained, which greatly affected their performance." 1375 1909 W2150962617.pdf 3 16 separator 0.8692044 ¶ 1909 1911 W2150962617.pdf 3 17 text 0.9990927 "Half (50%) of the students struggled with being expected to complete the experiments during the practicals by themselves in a fixed period of time, after never having been in a laboratory before." 1911 2113 W2150962617.pdf 3 18 separator 0.6621047 ¶ 2113 2115 W2150962617.pdf 3 19 text 0.99938905 "At least 20% said that both their physics knowledge and marks had improved and that they found physics at university more interesting because they now had unlimited access to books from the library. Some students reported that they found regular assessments to be difficult because they were not used to an environment of constant studying and testing." 2115 2483 W2150962617.pdf 3 20 separator 0.9953029 ¶ 2484 2486 W2150962617.pdf 3 21 title 0.78443664 Would you understand physics better if your study 2486 2536 W2150962617.pdf 3 22 text 0.6137371 materials 2536 2546 W2150962617.pdf 3 23 title 0.7649231 ¶ and 2547 2553 W2150962617.pdf 3 24 text 0.6939583 notes 2553 2559 W2150962617.pdf 3 25 title 0.74714243 were in isiZulu? 2559 2576 W2150962617.pdf 3 26 separator 0.9637784 ¶ 2576 2578 W2150962617.pdf 3 27 text 0.9951755 "A small number (14%) of students believed that they would understand physics better if the materials were in isiZulu because they felt they would understand the content better if it were in their own language. About 44% of the respondents were against learning materials being in isiZulu, with their main concern being that confusion may arise because isiZulu does not have translations for most of the English terms used in physics. A further 42% of the students were unsure or hesitant as they felt that it would make no difference to their performance as they had to study hard to understand the physics regardless if the language." 2578 3237 W2150962617.pdf 3 28 separator 0.99434626 ¶ 3238 3240 W2150962617.pdf 3 29 title 0.7027871 Are the labs easier to understand if they 3240 3282 W2150962617.pdf 3 30 text 0.5465827 are 3282 3286 W2150962617.pdf 3 31 title 0.49149278 3286 3287 W2150962617.pdf 3 32 text 0.7119167 explained to you 3287 3303 W2150962617.pdf 3 33 title 0.5669948 ¶ 3304 3306 W2150962617.pdf 3 34 text 0.55746776 in isiZulu? 3306 3318 W2150962617.pdf 3 35 separator 0.97021556 ¶ 3319 3321 W2150962617.pdf 3 36 text 0.997852 "Nearly 85% of students believed that their understanding would improve if they could ask questions in the laboratory in isiZulu with the demonstrators responding in English. About 15% of the students insisted that demonstrators explaining in English did not help them as their command of English was poor and they would become more confused. They saw no benefit in having an isiZulu-speaking demonstrator unless the entire lab was conducted in isiZulu." 3321 3789 W2150962617.pdf 3 37 separator 0.9950892 ¶ 3789 3791 W2150962617.pdf 3 38 title 0.8179478 Did you find the Physics tests difficult in terms of language ¶ 3791 3856 W2150962617.pdf 3 39 text 0.75027865 and if so why? 3856 3871 W2150962617.pdf 3 40 separator 0.9680358 ¶ 3871 3873 W2150962617.pdf 3 41 text 0.9996993 "A quarter (23%) of the respondents found the tests difficult because they did not understand the language of the questions and how to answer them. Only 5% of the students indicated that they were genuinely flummoxed by the questions because they did not understand what the English words ‘derive’, ‘explain’ or ‘prove’ meant. A majority (71%) of the students found the tests easy to understand in terms of language but struggled with the physics component of the question or the mathematical computations and calculations." 3873 4417 W2150962617.pdf 3 42 separator 0.9956987 ¶ 4418 4420 W2150962617.pdf 3 43 title 0.7961745 "Did the isiZulu-speaking tutors help you to better understand the work?" 4420 4495 W2150962617.pdf 3 44 separator 0.9389013 ¶ 4495 4497 W2150962617.pdf 3 45 text 0.99960726 "Nearly 67% of the students reported that having isiZulu-speaking tutors helped them better understand the work. The use of their own language made it easy to ask questions on things they did not comprehend in English. Most students opted to go only to the tutorials that were run by isiZulu-speaking tutors. They indicated that some of the tutors mixed isiZulu and English when explaining but they believed these tutorials still helped them to substantially improve." 4497 4982 W2150962617.pdf 3 46 separator 0.8414222 ¶ 4983 4985 W2150962617.pdf 3 47 text 0.9996378 "A small percentage (19%) of students said isiZulu-speaking tutors did not help because they still did not understand as the tutors used English throughout their explanations. A further 3% indicated that they did not understand explanations in both English and isiZulu and preferred only one language to be used." 4985 5309 W2150962617.pdf 3 48 separator 0.9952471 ¶ 5310 5312 W2150962617.pdf 3 49 title 0.7758081 Do you think you would perform better if 5312 5353 W2150962617.pdf 3 50 text 0.56422603 your notes 5353 5364 W2150962617.pdf 3 51 title 0.74806726 "were in isiZulu?" 5364 5384 W2150962617.pdf 3 52 separator 0.9694935 ¶ 5384 5386 W2150962617.pdf 3 53 text 0.99963653 "Close to 53% of the respondents believed they would perform better if their notes were in isiZulu because they would feel more comfortable using their vernacular. Nearly 26% indicated that they would not perform any better, with their main concern being that some physics terms cannot be explained in isiZulu and others do not even exist. A few students (4%) said they were already accustomed to studying in English, so changing the language would not really change their performance. About 5% of students indicated that they are not proficient in isiZulu, even though it is their first language." 5386 6007 W2150962617.pdf 3 54 separator 0.99298906 ¶ 6008 6010 W2150962617.pdf 3 55 text 0.92735755 "If your tests and exams were administered in isiZulu, do you think it would improve your performance?" 6010 6115 W2150962617.pdf 3 56 separator 0.9748449 ¶ 6115 6117 W2150962617.pdf 3 57 text 0.9995862 "Less than one-third (28%) of the students agreed that being tested in isiZulu would help their performance as they struggled to understand questions posed in English, even before attempting to answer the questions. This lack of understanding has cost them valuable time, hence if the questions were in isiZulu, they would have more time to concentrate on the physics content of the question." 6117 6524 W2150962617.pdf 3 58 separator 0.7559842 ¶ 6525 6527 W2150962617.pdf 3 59 text 0.9995804 "More than half (55%) of the students said it would not help their performance if the assessments were in isiZulu. These students said that they are already proficient in English and can explain more clearly in English than in isiZulu because of difficulties in translating some English words to isiZulu. These respondents were of the opinion that teaching science in isiZulu must be introduced at school and the vocabulary developed and introduced when they are still young." 6527 7020 W2150962617.pdf 3 60 separator 0.99438155 ¶ 7020 7022 W2150962617.pdf 3 61 text 0.96161187 "Do you think that being taught in isiZulu would make physics easier to understand and thus improve your performance in the subject?" 7022 7160 W2150962617.pdf 3 62 separator 0.9600836 ¶ 7160 7162 W2150962617.pdf 3 63 text 0.9990346 "Just under half (49%) of the students agreed that isiZulu lectures would improve their understanding and performance because it would make it easier for them to ask questions in class and to interact with the teacher." 7162 7386 W2150962617.pdf 3 64 paratext 0.6846744 Research Article 7386 7403 W2150962617.pdf 3 65 title 0.6016277 Student responses to being taught physics in isi 7403 7452 W2150962617.pdf 3 66 paratext 0.4825957 Zulu 7452 7456 W2150962617.pdf 3 67 separator 0.82773864 ¶ 7456 7458 W2150962617.pdf 3 68 paratext 0.9908386 Page 4 of 6 7458 7470 W2150962617.pdf 3 0 paratext 0.98770046 626 Mathews • STJ 2019, Vol 5, No 3, 621–642 0 46 W3004429072.pdf 5 1 separator 0.9934602 ¶ 46 48 W3004429072.pdf 5 2 text 0.9989378 "the texts themselves evidence the perspective of the underclass as well as the voice of the “ruling class”. Furthermore, post-colonial studies of the Hebrew Bible are re-examining the material from the perspective of Israel as the colonised vassal rather than an entity with any real power.13" 48 350 W3004429072.pdf 5 3 separator 0.9343237 ¶ 351 353 W3004429072.pdf 5 4 text 0.99937576 "Second, the particular texts I explore are texts responding to a context of crisis, whether personal or communal. If the context in which we are “struggling for the fullness of life” is tragedy, grief or death, then humanity is united in a common experience. It could be argued that for these texts the common perspective is that of the oppressed, those who struggle, even “the poor.” In Hebrew lament psalms and the prophetic literature, the term ‛anawîm is frequently used which seems to deliberately merge meanings of “poor,” “humble” and “pious.” Much debate exists in regard to the meaning of this term14 but decisions about semantic nuances do not undermine the assertion that those who suffer crisis become emotionally impoverished." 353 1121 W3004429072.pdf 5 5 separator 0.9454535 ¶ 1122 1124 W3004429072.pdf 5 6 text 0.9981601 "In the experience of grief all are coming from a perspective of struggle. As John de Gruchy has said, “Death ... is the great leveller.”15" 1124 1264 W3004429072.pdf 5 7 separator 0.9963571 ¶ 1264 1266 W3004429072.pdf 5 8 title 0.99330175 2. Biblical responses to crisis 1266 1298 W3004429072.pdf 5 9 separator 0.99569845 ¶ 1298 1300 W3004429072.pdf 5 10 text 0.9995001 "In the Old Testament we can find individual traditions that have “owned grief” in ways that may be helpful for our own crises. The biblical traditions discussed are not necessarily in chronological order – in fact, there is significant debate over the dating of most of them – and inevitably there is some commonality between their content. Nevertheless, they broadly reflect different but overlapping stages in the grieving process: inarticulate silence; expression of pain; switching into survival mode; reflection and analysis; and remembering or commemoration within liturgy." 1300 1901 W3004429072.pdf 5 11 separator 0.8737843 ¶ 1901 1903 W3004429072.pdf 5 12 text 0.99938756 "This survey of Old Testament perspectives begins with the book of Job – a book that transcends concrete historical placement yet has as its setting a situation of intense crisis: the physical, mental and spiritual anguish of an upright and innocent individual." 1903 2173 W3004429072.pdf 5 13 separator 0.9956058 ¶ 2173 2175 W3004429072.pdf 5 14 bibliography 0.9954214 "13 See Mark G. Brett, Decolonizing God: The Bible in the Tides of Empire (Sheffield: Sheffield Phoenix Press, 2008)." 2175 2296 W3004429072.pdf 5 15 separator 0.9821489 ¶ 2296 2298 W3004429072.pdf 5 16 bibliography 0.9967047 "14 See J. David Pleins, “Poor, Poverty (Old Testament),” in Anchor Bible Dictionary Vol. 5, ed. D. N. Freedman (New York: Doubleday, 1992), 402-414." 2298 2452 W3004429072.pdf 5 17 separator 0.99101484 ¶ 2452 2454 W3004429072.pdf 5 18 bibliography 0.93454367 15 de Gruchy, Led into Mystery , 5. 2454 2491 W3004429072.pdf 5 0 paratext 0.9745333 Open Peer Review on Qeios 0 25 W4246413605.pdf 0 1 separator 0.6633389 ¶ 25 27 W4246413605.pdf 0 2 paratext 0.9202242 Open Peer Review on Qeios 27 53 W4246413605.pdf 0 3 separator 0.92240334 ¶ 53 55 W4246413605.pdf 0 4 title 0.9308961 "National Research Service Award for Senior Fellows" 55 108 W4246413605.pdf 0 5 separator 0.89640975 ¶ 108 110 W4246413605.pdf 0 6 title 0.66095585 National Cancer Institute 110 136 W4246413605.pdf 0 7 separator 0.97078884 ¶ 136 138 W4246413605.pdf 0 8 paratext 0.68185633 Source 138 145 W4246413605.pdf 0 9 separator 0.75750214 ¶ 145 147 W4246413605.pdf 0 10 paratext 0.47972384 National Cancer Institute. 147 174 W4246413605.pdf 0 11 separator 0.8454431 ¶ 175 177 W4246413605.pdf 0 12 paratext 0.40028542 National Research Service Award for Senior Fellows 177 228 W4246413605.pdf 0 13 bibliography 0.34685743 ¶ 228 231 W4246413605.pdf 0 14 paratext 0.5120385 . NCI 231 236 W4246413605.pdf 0 15 bibliography 0.33174813 ¶ 236 238 W4246413605.pdf 0 16 paratext 0.43929648 The 238 242 W4246413605.pdf 0 17 bibliography 0.4299817 saurus 242 248 W4246413605.pdf 0 18 paratext 0.43485036 . 248 249 W4246413605.pdf 0 19 bibliography 0.43930694 Code 249 254 W4246413605.pdf 0 20 paratext 0.442735 C19497. 254 262 W4246413605.pdf 0 21 separator 0.992924 ¶ 262 264 W4246413605.pdf 0 22 text 0.95634365 "To provide senior fellowship support to established scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent research investigators in scientific health-related fields relevant to the missions of the NCI. This award is designed for sabbatical periods." 264 657 W4246413605.pdf 0 23 separator 0.97833 ¶ 657 659 W4246413605.pdf 0 24 paratext 0.95225126 "Qeios · Definition, February 2, 2020" 659 703 W4246413605.pdf 0 25 separator 0.5528883 ¶ 703 705 W4246413605.pdf 0 26 paratext 0.9561318 "Qeios ID: FL4QP1 · https://doi.org/10.32388/FL4QP1 1 /" 705 768 W4246413605.pdf 0 27 separator 0.79376626 ¶ 768 770 W4246413605.pdf 0 28 paratext 0.65144396 1 770 772 W4246413605.pdf 0 0 separator 0.98823774 ¶ 1 2 W3120560435.pdf 1 1 paratext 0.63106734 3) 2 5 W3120560435.pdf 1 2 title 0.6959788 Chevron Refinery Fire 5 27 W3120560435.pdf 1 3 paratext 0.67383534 "( The U.S. Chemical Safety Board, 2015)" 27 71 W3120560435.pdf 1 4 separator 0.99049604 ¶ 73 75 W3120560435.pdf 1 5 text 0.99925536 "On August 6, 2012, a catastrophic pipe rupture occurred in the Chevron Richmond refinery causing a fire which resulted in a large plume of vapor, particles, and smoke travelling across the surr ounding area. Six employees suffered minor injuries and approximately 15,000 people from surrounding communities sought medical treatment. The cause of the rupture was sulfidation corrosion." 77 484 W3120560435.pdf 1 6 separator 0.9868917 ¶ ¶ 486 492 W3120560435.pdf 1 7 paratext 0.5829034 4) 492 495 W3120560435.pdf 1 8 title 0.76361144 Macondo Blowout and Explosion 495 525 W3120560435.pdf 1 9 paratext 0.50090736 ( The U 525 533 W3120560435.pdf 1 10 title 0.5731842 . 533 534 W3120560435.pdf 1 11 paratext 0.4832807 "S. Chemical Safety Board, 2016 a)" 534 570 W3120560435.pdf 1 12 separator 0.98719823 ¶ 571 573 W3120560435.pdf 1 13 text 0.9993185 "On April 20, 2010, the control of the Macondo oil well was lost during temporary well -abandonment activities on the Deepwater Horizon drilling rig resulting in an uncontrolled release of oil and gas from the well. On the rig, explosions and fire occurred which led to 11 deaths and 17 serious physical injuries and massive marine and coastal damage." 575 945 W3120560435.pdf 1 14 separator 0.8752235 ¶ 947 949 W3120560435.pdf 1 15 text 0.9990943 "Post-Macondo safety culture assessment by BP did not assess whether the company ’s policies for risk management and operational success which were recommended in above mentioned Baker Panel Report were followed at Macondo and no new finding was added from the previous report." 950 1242 W3120560435.pdf 1 16 separator 0.97464544 ¶ ¶ 1244 1250 W3120560435.pdf 1 17 paratext 0.49130672 5) 1250 1253 W3120560435.pdf 1 18 title 0.7804164 Tesoro Martinez Sulfuric Acid Spill ( 1253 1291 W3120560435.pdf 1 19 paratext 0.51199937 The U 1291 1297 W3120560435.pdf 1 20 title 0.62805474 . 1297 1298 W3120560435.pdf 1 21 paratext 0.5000473 "S. Chemical Safety Board, 2016 b)" 1298 1335 W3120560435.pdf 1 22 separator 0.98900545 ¶ 1336 1338 W3120560435.pdf 1 23 text 0.99960816 "This report is the case study on process safety culture of the sulfuric acid releases occurring twice in succession at the Tesoro Martinez refinery. On February 12, 2014, the tubing of an acid sampling system came apart, spraying two operators and on March 10, 2014, two con tract workers were sprayed during planned non -routine maintenance work. The investigation found that a weak process safety culture created conditions conducive to the recurrence of sulfuric acid incidents that caused worker injuries over several years." 1340 1902 W3120560435.pdf 1 24 separator 0.97291285 ¶ ¶ 1904 1910 W3120560435.pdf 1 25 paratext 0.5635557 6) 1910 1913 W3120560435.pdf 1 26 title 0.7296325 Williams Olefin Plant Explosion and Fire 1913 1954 W3120560435.pdf 1 27 paratext 0.46385098 ( The U 1954 1962 W3120560435.pdf 1 28 title 0.5321129 . 1962 1963 W3120560435.pdf 1 29 paratext 0.37771893 S. 1963 1965 W3120560435.pdf 1 30 bibliography 0.42414445 ¶ 1966 1968 W3120560435.pdf 1 31 paratext 0.45588094 Chemical Safety Board, 2016 c) 1968 2000 W3120560435.pdf 1 32 separator 0.9901588 ¶ 2001 2003 W3120560435.pdf 1 33 text 0.99952614 "On June 13, 2013, catastrophic equipment rupture, explosion, and fire occurred during non -routine operational activities in the Williams olefin plant, which killed two employees. The technical cause of the rupture was the introduction of the valves in 2001 which isolated the equipment from a protective pressure relief valve." 2005 2349 W3120560435.pdf 1 34 separator 0.9971206 ¶ 2351 2353 W3120560435.pdf 1 35 title 0.9917738 "2.2 Key P rinciple s and Essential Features of Process Safety Culture in RBPS" 2353 2435 W3120560435.pdf 1 36 separator 0.99327576 ¶ 2437 2439 W3120560435.pdf 1 37 text 0.99877787 "According to RBPS, following three key principles should be addressed in management systems for the process safety culture. Items listed for each key principle are the essential features. The abbreviation in the parenthes is at the end of each key principle and essential feature will be used in the following section 3." 2439 2780 W3120560435.pdf 1 38 separator 0.900466 ¶ ¶ 2781 2787 W3120560435.pdf 1 39 text 0.9238844 "1) Maintain a dependable practice (DP) a. Establish process safety as a core value (DP1) b. Provide strong leadership (DP2) c. Establish and enforce high standards of performance (DP3) d. Document the process safety culture emphasis and approach (DP4) " 2787 3062 W3120560435.pdf 1 40 separator 0.88750166 ¶ ¶ 3062 3067 W3120560435.pdf 1 41 text 0.51011556 2) Develop and implement 3067 3092 W3120560435.pdf 1 42 title 0.5066596 a s ound culture (SC 3092 3113 W3120560435.pdf 1 43 text 0.42078903 ) 3113 3114 W3120560435.pdf 1 44 separator 0.84278226 ¶ 3116 3118 W3120560435.pdf 1 45 text 0.91195756 "a. Maintain a sense of vulnerability (SC1) b. Empower individuals to successfully fulfill their safety responsibilities (SC2) c. Defer to expertise (SC3) d. Ensure open and effective communications (SC4) e. Establish a questioning/learning environment (SC5) f. Foster mutual trust (SC6) g. Provide timely response to process safety issues and concerns (SC7)" 3120 3521 W3120560435.pdf 1 46 separator 0.9527709 ¶ ¶ 3523 3529 W3120560435.pdf 1 47 title 0.7308686 3) Monitor and Guide the Culture (MG) 3529 3567 W3120560435.pdf 1 48 separator 0.9636868 ¶ 3569 3571 W3120560435.pdf 1 49 text 0.96090275 "a. Provide continuous monitoring of performance (MG1)" 3573 3630 W3120560435.pdf 1 50 separator 0.99622726 ¶ 3632 3634 W3120560435.pdf 1 51 title 0.9898107 "3 CSB Safety Culture Weaknesses related to RBPS Essential Features" 3634 3704 W3120560435.pdf 1 52 separator 0.9854684 ¶ 3707 3709 W3120560435.pdf 1 53 text 0.99894196 "In this section, the weaknesses of safety culture reported in the six investigation reports in section 2 -1 are introduced and are related to either of the essential features listed in section 2 -2. The abbreviation in the parenthes is at the end of each report and weakness will be used in Table 1 at the end of th is section." 3709 4052 W3120560435.pdf 1 54 separator 0.9670278 ¶ ¶ 4054 4060 W3120560435.pdf 1 55 title 0.9260641 1) BP America Refinery Explosion (BP) 4060 4098 W3120560435.pdf 1 56 separator 0.9855929 ¶ 4100 4102 W3120560435.pdf 1 57 text 0.9837299 "a. Lack of reporting and learning culture (BP1) Reporting culture is directly related to communications (SC4) and communication is based on mutual trust (SC6) between employees and managers. Learning culture is directly related to questioning/learni ng environment (SC5)." 4102 4392 W3120560435.pdf 1 58 separator 0.680126 ¶ ¶ 4394 4400 W3120560435.pdf 1 59 text 0.6609957 b. Lack of focus on controlling major 4400 4438 W3120560435.pdf 1 60 title 0.49077472 4438 4439 W3120560435.pdf 1 61 text 0.6943742 hazard risk (BP2) 4439 4456 W3120560435.pdf 1 62 separator 0.6493579 4458 4459 W3120560435.pdf 1 63 text 0.99343497 "¶ BP executives relied only on personal safety metrics to drive safety performance, which means that they focused only on personal safety and not on process safety. This is related to the lack to establish process safety as a core value (DP1)." 4459 4717 W3120560435.pdf 1 64 separator 0.9293829 ¶ ¶ 4719 4726 W3120560435.pdf 1 65 title 0.9536622 c. Safety implications of organizational change (BP3) 4726 4780 W3120560435.pdf 1 66 separator 0.9849483 ¶ 4782 4784 W3120560435.pdf 1 67 text 0.9996182 "Poorly managed corporate mergers accompanied by leadership and organizational change and also the budget cuts both show weaknesses in safety culture. These factors are related to the lack in providing strong leadership (DP2) and the lack in establishing high standards of performance (DP3)." 4786 5092 W3120560435.pdf 1 68 separator 0.9678255 ¶ ¶ 5094 5100 W3120560435.pdf 1 69 title 0.9577131 2) Tesoro Refinery Fatal Explosion and Fire (TA) 5100 5149 W3120560435.pdf 1 70 separator 0.9844808 ¶ 5151 5153 W3120560435.pdf 1 71 text 0.98630154 "a. Management had normalized hazardous conditions (TA1) The leaks from the heat exchanger which caused this accident ha d occurred repeatedly at every startup operation and hazardous conditions were routinely developed for years. This shows the weakness in " 5153 5431 W3120560435.pdf 1 72 separator 0.58908266 ¶ 5431 5432 W3120560435.pdf 1 73 paratext 0.9718547 2MATEC Web of Conferences 333, 10001 (2021) https://doi.org/10.1051/matecconf/202133310001 5432 5523 W3120560435.pdf 1 74 separator 0.7519392 ¶ 5523 5525 W3120560435.pdf 1 75 paratext 0.9743209 APCChE 2019 5525 5537 W3120560435.pdf 1 0 paratext 0.97874725 Journal of Addiction 5 0 22 W2790250029.pdf 4 1 separator 0.98859 ¶ 22 24 W2790250029.pdf 4 2 title 0.9826157 Table 2: Characteristics according to mortality status. 24 80 W2790250029.pdf 4 3 separator 0.9905977 ¶ 80 82 W2790250029.pdf 4 4 table 0.9962483 "Women Men Deceased, % (n) Survived, % (n) p value Deceased, % (n) Survived, % (n) p value N= 16 788 252 5979 Mean age 39.75 years 36.14 years 0.201 34.90 years 32.20 years <0.001 Urban residence, large city 31.3 (5) 39.6 (312) 0.610 44.8 (113) 45.6 (2725) 0.819 Country of birth, Nordic country 93.8 (15) 89.6 (706) 1.000 86.5 (218) 78.2 (4677) 0.002 Homelessness, last 30 days 6.3 (1) 19.3 (152) 0.331 19.4 (49) 16.8 (1003) 0.268 Client has children 75.0 (12) 64.6 (509) 0.443 50.8 (128) 45.0 (2692) 0.071 Chronic physical disease 62.5 (10) 57 .0 (449) 0.659 52.8 (133) 44.5 (2659) 0.009 Client has worked for the last 3 yrs 31.3 (5) 36.2 (285) 0.685 28.2 (71) 39.4 (2354) <0.001 Client has partner with substance abuse 37 .5 (6) 33.9 (267) 0.762 10.3 (26) 9.9 (594) 0.842 Lifetime history of substance abuse ( >1y r ) Binge drinking 62.5 (10) 39.7 (313) 0.066 47 .2 (119) 41.0 (2453) 0.050 Heroin 37 .5 (6) 18.9 (149) 0.062 33.3 (84) 16.9 (1008) <0.001 Methadone 12.5 (2) 4.6 (36) 0.127 4.4 (11) 2.8 (168) 0.148 Other opioids 18.8 (3) 14.1 (111) 0.486 18.7 (47) 12.5 (749) 0.004 Sedatives 43.8 (7) 26.4 (208) 0.121 40.9 (103) 28.5 (1704) <0.001 Cocaine 12.5 (2) 5.3 (42) 0.217 11.1 (28) 13.8 (826) 0.221 Amphetamine 56.3 (9) 54.4 (429) 0.886 58.7 (148) 50.3 (3006) 0.009 Cannabis 43.8 (7) 38.1 (300) 0.643 62.3 (157) 53.2 (3180) 0.004 Injection drug use 56.3 (9) 48.2 (380) 0.525 59.5 (150) 39.6 (2366) <0.001 M e a nn u m b e ro fs u b s t a n c e su s e d ,l a s t3 0d a y s 1.4 1.3 0.769 1.7 1.4 <0.001 Main crime in index verdict Violent crime 6.3 (1) 10.2 (80) 1.000 15.5 (39) 13.4 (799) 0.336 Property crime 6.3 (1) 15.6 (123) 0.489 23.4 (59) 21.9 (1308) 0.564 Drug crime 31.3 (5) 24.6 (194) 0.543 21.0 (53) 23.0 (1376) 0.463 Financial crime 0.0 (0) 6.2 (49) 0.616 2.4 (6) 3.9 (232) 0.224 Lifetime history of psychiatric problemsHospitalization 25.0 (4) 21.7 (171) 0.761 18.3 (46) 13.8 (825) 0.046 Suicide attempt 43.8 (7) 35.0 (276) 0.469 25.4 (64) 18.7 (1121) 0.008 Depression 68.8 (11) 62.6 (493) 0.612 47 .2 (119) 49.4 (2954) 0.497 Anxiety 68.8 (11) 66.6 (525) 0.858 54.8 (138) 51.2 (3060) 0.265 Cognitive problems 62.5 (10) 52.7 (415) 0.435 54.0 (136) 51.6 (3083) 0.454 Hallucinations 12.5 (2) 13.2 (104) 1.000 11.9 (30) 12.8 (763) 0.689 Difficulty controlling violent behaviour 37 .5 (6) 32.1 (253) 0.648 38.1 (96) 42.0 (2509) 0.223" 82 2495 W2790250029.pdf 4 5 separator 0.9761263 ¶ 2495 2497 W2790250029.pdf 4 6 text 0.9742379 "associated with criminal recidivism among both the male clients. These results support previous findings that criminalrecidivism among criminal clients with substance abuse isdirectly linked to the severity of the substance abuse [17]." 2497 2735 W2790250029.pdf 4 7 separator 0.790346 ¶ 2735 2737 W2790250029.pdf 4 8 text 0.99854124 "However, no substance abuse variable was associated with criminal recidivism among the female prisoners. The onlyvariables that were associated with elevated risk factors forcriminal recidivism in the female study population were maincrime in index verdict being a property crime and having apartner with substance abuse. This suggests that femaleoffenders have different factors sustaining a criminal lifestylethan male offenders.I nt h eb a s e l i n ec o m p a r i s o n ,t h ew o m e ni nt h i ss t u d y reported having partners with substance abuse to a muchhigher extent than their male counterparts. Previous researchon gender differences in drug-use careers has identified that f e m a l es u b s t a n c ea b u s e r sa r ei n fl u e n c e dt ou s ed r u g sb y sexual partners or spouses, as opposed to male substanceabusers, who are more influenced by peer pressure [20].Importantly, in the present study, having a partner withsubstance abuse was predictive of criminal recidivism. Intu-itively, this calls for further focus on the treatment of femaleoffenders’ partners, in order to facilitate a favorable outcomein substance abuse treatment and rehabilitation of women." 2737 3929 W2790250029.pdf 4 0 text 0.9259411 "provided the lowest jaw temperatures, although with a broader area of thermal damage." 0 87 W2793023662.pdf 8 1 separator 0.9960332 ¶ 87 89 W2793023662.pdf 8 2 title 0.961415 Acknowledgments 89 105 W2793023662.pdf 8 3 separator 0.99432695 ¶ 105 107 W2793023662.pdf 8 4 text 0.9772556 "The authors would like to thank Dr. Kathryn Osann, PhD, for her help with statistical data analysis. In addition, wewould like to express our appreciation to histopathologylaboratory technicians from Ronald Reagan University of California, Los Angeles Medical Center, for their help in processing the samples." 107 423 W2793023662.pdf 8 5 separator 0.58432376 ¶ 423 425 W2793023662.pdf 8 6 text 0.98304385 "We would also like to thank Dr. Ralph V. Clayman for his critical review and feedback on the manuscript." 425 532 W2793023662.pdf 8 7 separator 0.9960648 ¶ 532 534 W2793023662.pdf 8 8 title 0.9799334 Authors’ Contributions 534 557 W2793023662.pdf 8 9 separator 0.9924545 ¶ 557 559 W2793023662.pdf 8 10 text 0.995731 "J.L. and Z.O. had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracyof data analysis. A.L. and J.L. carried out study concept and design. All authors acquired, analyzed, or interpreted data. Z.O. and J.L. drafted the article. Z.O., J.L., and Clayman criticallyreviewed the article for important intellectual content. K.O.carried out statistical analysis. J.L. supervised the study." 559 1011 W2793023662.pdf 8 11 separator 0.99607605 ¶ 1011 1013 W2793023662.pdf 8 12 title 0.9609577 Author Disclosure Statement 1013 1041 W2793023662.pdf 8 13 separator 0.9878799 ¶ 1041 1043 W2793023662.pdf 8 14 text 0.67744035 No competing financial interests exist. 1043 1082 W2793023662.pdf 8 15 separator 0.9900919 ¶ 1082 1084 W2793023662.pdf 8 16 title 0.85931873 References 1084 1095 W2793023662.pdf 8 17 separator 0.98874545 ¶ 1095 1097 W2793023662.pdf 8 18 bibliography 0.9977611 "1. Entezari K, Hoffmann P, Goris M, Peltier A, Van Veltho- ven R. A review of currently available vessel sealing sys- tems. Minimally invasive therapy & allied technologies: MITAT 2007;16:52–57." 1097 1298 W2793023662.pdf 8 19 separator 0.9543841 ¶ 1298 1300 W2793023662.pdf 8 20 bibliography 0.9978064 "2. Janssen PF, Brolmann HA, Huirne JA. Effectiveness of electrothermal bipolar vessel-sealing devices versus other electrothermal and ultrasonic devices for abdominal surgi- cal hemostasis: A systematic review. Surg Endosc 2012;26: 2892–2901." 1300 1551 W2793023662.pdf 8 21 separator 0.97350216 ¶ 1551 1553 W2793023662.pdf 8 22 bibliography 0.99783033 "3. Landman J, Kerbl K, Rehman J, et al. Evaluation of a vessel sealing system, bipolar electrosurgery, harmonicscalpel, titanium clips, endoscopic gastrointestinal anasto- mosis vascular staples and sutures for arterial and venous ligation in a porcine model. J Urol 2003;169:697–700." 1553 1844 W2793023662.pdf 8 23 separator 0.9656587 ¶ 1844 1846 W2793023662.pdf 8 24 bibliography 0.9978333 "4. Kennedy JS, Stranahan PL, Taylor KD, Chandler JG. High- burst-strength, feedback-controlled bipolar vessel sealing. Surg Endosc 1998;12:876–878." 1846 1998 W2793023662.pdf 8 25 separator 0.966187 ¶ 1998 2000 W2793023662.pdf 8 26 bibliography 0.99786866 "5. Hruby GW, Marruffo FC, Durak E, Collins SM, Pierorazio P, Humprey PA, Mansukhani MM, Landman J. Evaluation of surgical energy devices for vessel sealing and peripheral energy spread in a porcine model. J Urol 2007;178:2689– 2693." 2000 2241 W2793023662.pdf 8 27 separator 0.9724456 ¶ 2241 2243 W2793023662.pdf 8 28 bibliography 0.99793637 "6. MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR. Arterial blood pressure response to heavy resistance exer- cise. J Appl Physiol 1985;58:785–790." 2243 2401 W2793023662.pdf 8 29 separator 0.95527065 ¶ 2401 2403 W2793023662.pdf 8 30 bibliography 0.99791014 "7. Narloch JA, Brandstater ME. Influence of breathing tech- nique on arterial blood pressure during heavy weight lift- ing. Arch Phys Med Rehabil 1995;76:457–462." 2403 2569 W2793023662.pdf 8 31 separator 0.97454166 ¶ 2569 2571 W2793023662.pdf 8 32 bibliography 0.9979748 "8. Newcomb WL, Hope WW, Schmelzer TM, Heath JJ, Norton HJ, Lincourt AE, Heniford BT, Iannitti DA. Com- parison of blood vessel sealing among new electrosurgical and ultrasonic devices. Surg Endosc 2009;23:90–96.9. Timm RW, Asher RM, Tellio KR, Welling AL, Clymer JW, Amaral JF. Sealing vessels up to 7 mm in diameter solely with ultrasonic technology. Med Devices (Auckl) 2014;7: 263–271." 2571 2972 W2793023662.pdf 8 33 separator 0.98114663 ¶ 2972 2974 W2793023662.pdf 8 34 bibliography 0.9978018 "10. Reyes DA, Brown SI, Cochrane L, Motta LS, Cuschieri A. Thermal fusion: Effects and interactions of temperature, compression, and duration variables. Surg Endosc 2012;26: 3626–3633." 2974 3165 W2793023662.pdf 8 35 separator 0.9752486 ¶ 3165 3167 W2793023662.pdf 8 36 bibliography 0.9978424 "11. Phillips CK, Hruby GW, Mirabile G, Motamedine P, Durak E, Lehman DS, Hong PW, Landman J. The effect of in- traluminal content on the bursting strength of vessels li- gated with the harmonic ACE and LigaSure V. J Endourol 2008;22:1383–1387." 3167 3419 W2793023662.pdf 8 37 separator 0.97005486 ¶ 3419 3421 W2793023662.pdf 8 38 bibliography 0.9978596 "12. Sindram D, Martin K, Meadows JP, Prabhu AS, Heath JJ, McKillop IH, Iannitti DA. Collagen-elastin ratio predicts burst pressure of arterial seals created using a bipolar vessel sealing device in a porcine model. Surg Endosc 2011;25: 2604–2612." 3421 3676 W2793023662.pdf 8 39 separator 0.96844184 ¶ 3676 3678 W2793023662.pdf 8 40 bibliography 0.99786526 "13. Sigel B, Dunn MR. The mechanism of blood vessel closure by high frequency electrocoagulation. Surg Gynecol Obstet 1965;121:823–831." 3678 3818 W2793023662.pdf 8 41 separator 0.97024715 ¶ 3818 3820 W2793023662.pdf 8 42 bibliography 0.997721 "14. Eick S, Loudermilk B, Walberg E, Wente MN. Rationale, bench testing and in vivo evaluation of a novel 5 mm lap- aroscopic vessel sealing device with homogeneous pressure distribution in long instrument jaws. Ann Surg Innov Res 2013;7:15." 3820 4070 W2793023662.pdf 8 43 separator 0.9713332 ¶ 4070 4072 W2793023662.pdf 8 44 bibliography 0.9978974 "15. Kim FJ, Chammas MF, Jr.,GewehrE, et al. Temperature safety profile of laparoscopic devices: Harmonic ACE (ACE), Liga- Sure V (LV), and plasma trisector (PT). Surg Endosc 2008;22: 1464–1469." 4072 4271 W2793023662.pdf 8 45 separator 0.9735615 ¶ 4271 4273 W2793023662.pdf 8 46 bibliography 0.99747175 "16. Milsom J, Trencheva K, Monette S, Pavoor R, Shukla P, Ma J, Sonoda T. Evaluation of the safety, efficacy, and versatility of a new surgical energy device (THUNDER- BEAT) in comparison with Harmonic ACE, LigaSure V, and EnSeal devices in a porcine model. J Laparoendosc Adv Surg Tech A 2012;22:378–386." 4273 4588 W2793023662.pdf 8 47 separator 0.9783397 ¶ 4588 4590 W2793023662.pdf 8 48 bibliography 0.99795234 "17. Campbell PA, Cresswell AB, Frank TG, Cuschieri A. Real- time thermography during energized vessel sealing and dissection. Surg Endosc 2003;17:1640–1645." 4590 4751 W2793023662.pdf 8 49 separator 0.9912494 ¶ 4751 4753 W2793023662.pdf 8 50 contact 0.9922551 "Address correspondence to: Jaime Landman, MD Department of Urology University of California, Irvine 333 City Boulevard West, Suite 2100 Orange, CA 92868 E-mail: landmanj@uci.edu" 4753 4943 W2793023662.pdf 8 51 separator 0.9956041 ¶ 4943 4945 W2793023662.pdf 8 52 title 0.9473861 Abbreviations Used 4945 4964 W2793023662.pdf 8 53 separator 0.6702393 ¶ 4964 4966 W2793023662.pdf 8 54 table 0.9511049 "C51⁄4Caiman 5 ES1⁄4EnSeal G2 HA1⁄4Harmonic Ace Plus HA71⁄4Harmonic Ace +7 LS1⁄4LigaSure (5mm to 37cm, blunt tip laparoscopic sealer)" 4966 5099 W2793023662.pdf 8 55 separator 0.99199426 ¶ 5099 5101 W2793023662.pdf 8 56 title 0.8625444 VSDs1⁄4vessel sealing devicesCOMPARISON OF VESSEL SEALING DEVICES 5101 5165 W2793023662.pdf 8 57 paratext 0.6084684 337 5165 5169 W2793023662.pdf 8 0 paratext 0.98955625 Agronomy 2022 ,12, 826 2 of 19 0 30 W4220877882.pdf 1 1 separator 0.9924735 ¶ 30 32 W4220877882.pdf 1 2 text 0.9985637 "specific studies aimed at preserving the biodiversity of these sensitive agroecosystems, rich in exclusive weed plants [ 12], including many crop wild relatives (CWRs) which are useful for maintaining the high quality of forage due to the possible crossing between cultivated and wild species [13]." 32 336 W4220877882.pdf 1 3 separator 0.79286265 ¶ 336 338 W4220877882.pdf 1 4 text 0.99744 According to the literature, biostimulants can play an important role in this process [14–20] . 338 434 W4220877882.pdf 1 5 separator 0.9608554 ¶ 434 436 W4220877882.pdf 1 6 text 0.9990648 "Du Jardin [ 21] defined a plant biostimulant as any substance or microorganism applied to plants, seeds, or in the rhizosphere with the aim to stimulate natural processes in plants, enhance nutrition efficiency and/or abiotic stress tolerance, regardless of its nutrient con- tent, or a mixture of such substances and/or microorganisms. Agricultural biostimulants are a group of compounds, substances (trace elements, enzymes, plant growth regulators, macroalgal extracts), and microorganisms applied to plants or soil in order to regulate and enhance physiological processes in crops, thus making them more efficient [ 20,22]. By affecting biochemical, morphological, and physiological processes, biostimulants improve nutrient use efficiency in plants [ 23]. A beneficial influence of biostimulants on root system development, water retention capacity, chlorophyll content, and photosynthetic rate, con- tributing to increased nutrient uptake by crops, has been reported by Murawska et al. [ 18], Sharma et al. [ 20], Kleiber and Markiewicz [ 24], and Matysiak et al. [ 25]. The application of products that promote plant growth and development makes it possible to minimize the use of mineral fertilizers, in particular N rates [ 18]. Godlewska and Ciepiela [ 14–17] and Sosnowski et al. [ 19] observed a positive influence of biostimulants on the feed value of forage grasses. Similar results were reported by Murawska et al. [ 18], Kleiber and Markiewicz [ 24], Matysiak et al. [ 25], Sivasankari et al. [ 26], and Karr-Lilienthal et al. [ 27], who analyzed various crop species." 436 2048 W4220877882.pdf 1 7 separator 0.9679173 ¶ 2048 2050 W4220877882.pdf 1 8 text 0.9891088 "The biostimulants used in the present experiment are biological, environmentally- friendly formulations that support plant growth and development [ 28–30]. Blatt Boden- Foliar is a microbial solution that consists mainly of lactic acid bacteria: Lactobacillus casei (5109cfu mL" 2050 2335 W4220877882.pdf 1 0 separator 0.8626564 ¶ 1 2 W3199507157.pdf 0 1 paratext 0.8746737 "مجلة كلية اآلداب جامعة بورسعيد العدد التاسع عشر / يناير 2222م ¶ 701 ¶ ¶ ¶" 4 149 W3199507157.pdf 0 2 separator 0.78373915 "¶ ¶ ¶" 151 165 W3199507157.pdf 0 3 title 0.972034 التعليل الصوتي لظاهرة اإلعالل بالنقل في ضوء علم اللغة الحديث 165 226 W3199507157.pdf 0 4 separator 0.97957546 ¶ 228 230 W3199507157.pdf 0 5 title 0.9178207 نماذج تطبيقية من القرآن الكريم 230 261 W3199507157.pdf 0 6 separator 0.9849348 ¶ ¶ 263 269 W3199507157.pdf 0 7 contact 0.92949104 "إعداد ¶ أميرة صالح حامد عطعوط باحثة ماجستير بقسم اللغة العربية وآدابها كلية اآلداب، جامعة بورسعيد ¶" 269 388 W3199507157.pdf 0 8 separator 0.36342648 390 391 W3199507157.pdf 0 9 paratext 0.7575947 "¶ DOI: 10.21608/jfpsu.2022.193842 ¶" 391 433 W3199507157.pdf 0 10 separator 0.7813326 "¶ ¶ ¶" 435 449 W3199507157.pdf 0 0 paratext 0.9897404 Fermentation 2023 ,9, 460 7 of 13 0 33 W4376138256.pdf 6 1 separator 0.9952252 ¶ 33 35 W4376138256.pdf 6 2 title 0.9748039 Table 3. Proteolytic systems genes in L. helveticus H9 and L. paracasei ABK genomes. 35 120 W4376138256.pdf 6 3 separator 0.9897128 ¶ 120 122 W4376138256.pdf 6 4 table 0.99501616 "Enzyme GeneL. helveticus H9 L. paracasei ABK Number of GenesLocus Number in the GenomeNumber of GenesLocus Number in the Genome CEP proteinasesprtB 1 MBU6033914 1 MBU6046327 prtP 1 MBU6034695 1 MBU6048028 EndopeptidasepepO 2MBU6033720 MBU60346942MBU6046960 MBU6047360 pepF 1 MBU6034722 3MBU6046494 MBU6047890 MBU6047627 pepE 1 MBU6034026 1 MBU6047326 AminopeptidasespepC 3MBU6034983 MBU6034023 MBU60346591 MBU6047325 pepN 1 MBU6034546 1 MBU6048029 prolinase, pepP 1 MBU6035018 1 MBU6046149 glutaminopeptidase, pepA 1 MBU6034400 0 no * proline iminopeptidase, pepI 1 MBU6034385 1 MBU6046842 prolidase, pepQ 1 MBU6034747 1 MBU6046550 pepS 0 no 1 MBU6047768 Oligo-/Tri-/Di- peptidasesprolinase, pepR 1 MBU6034760 1 MBU6047007 tripeptidase, pepT 2MBU6034325 MBU60344290 no X-prolil dipeptidyl aminopeptidase, pepX1 MBU6034686 1 MBU6046155 dipepidase, pepV 1 MBU6034208 1 MBU6047856 dipepidase, pepD 4MBU6034175 MBU6033703 MBU6034538 MBU60344703MBU6046618 MBU6047722 MBU6047002 Total: 23 20 no *—not found." 122 1200 W4376138256.pdf 6 5 separator 0.98888624 ¶ 1200 1202 W4376138256.pdf 6 6 text 0.9994405 "For the postbiotic substances obtained after MRS fermentation, the concentration of all amino acids decreased in both MRS_Lh or MRS_Lp compared to the unfermented medium (Table 3 and Figure 1). The exceptions were phenylalanine and tyrosine, which were absent in MRS, MRS_Lh or MRS_Lp, and methionine, for which the concentration in MRS_Lh was the same as in MRS and increased two-fold in MRS_Lp. Among the amino acids, for which the concentration decreased after fermentation, four amino acids (histidine, cysteine, valine and threonine) totally disappeared both in MRS_Lh and MRS_Lp; nine amino acids (glutamate, glutamine, arginine, proline, aspartate, asparagine, glycine and serine) were present with the same concentration both in MRS_Lh and MRS_Lp; three amino acids (leucine, isoleucine and tryptophan) were present in MRS_Lp at twice the concentration compared to MRS_Lh; and for lysine, its concentration was slightly higher (by 44%) in MRS_Lh compared to MRS_Lp." 1202 2198 W4376138256.pdf 6 7 separator 0.95326245 ¶ 2198 2200 W4376138256.pdf 6 8 text 0.9994638 "Hence, during the RSM fermentation by both strains of probiotic cultures, free amino acids were enriched, and the content of free amino acids in the RSM_Lh postbiotic were somewhat higher than in RSM_Lp. Since amino acids with common biosynthetic precursors did not change their concentration in a similar way during fermentation, it can be assumed" 2200 2555 W4376138256.pdf 6 0 text 0.9834675 "following manufacturer's protocol, and resuspended in50μlofElution Buffer (10mM Tris, pH8.3) (Qiagen)." 0 104 W2606029971.pdf 9 1 separator 0.97832227 ¶ 104 106 W2606029971.pdf 9 2 text 0.9971957 "Tofacilitate library construction, weadapted theIllumina 16Smetabarcoding protocol, adding tails to12S-V5 primers [29] described above. Primers were obtained from Integrated DNA Technologies with thefollowing sequences (Illumina tails initalics):" 106 357 W2606029971.pdf 9 3 separator 0.99091065 ¶ 357 359 W2606029971.pdf 9 4 table 0.8913011 "Forward: 5’-TCGTCGGCAGCGTCAGATGTGTATAAGAGACAGACTGGGATTAGA TACCCC-3’. Reverse: 5’-GTCTCGTGGGCTCGGAGATGTGTATAAGAGACAGTAGAA CAGGCTCCTCTAG-3’. The amplified target notincluding primers isapproximately 110 bp;" 359 570 W2606029971.pdf 9 5 text 0.5677293 theentire amplicon including tail 570 603 W2606029971.pdf 9 6 table 0.4882408 ed 603 605 W2606029971.pdf 9 7 text 0.49797058 primers isapproximately 605 629 W2606029971.pdf 9 8 table 0.5087296 200b 629 634 W2606029971.pdf 9 9 text 0.5475986 p. 634 636 W2606029971.pdf 9 10 separator 0.9816199 ¶ 636 638 W2606029971.pdf 9 11 text 0.99802697 "Amplifications were done with Illustra puReTaq Ready-To-Go PCR beads (GE Healthcare), 5μlDNA (representing eDNA from 100mLofwater from estuary orcontrol samples) or5μl H2O fornegative PCR control, 200nMeach primer, infinal volume 25μl.Parameters were 95ÊC x7m,then 40cycles of(95ÊC x30s,52ÊC x30s,72ÊC x30s),followed by72ÊC for10 m,and hold at4ÊC. 5μlofeach reaction were runona2%agarose gelwith SYBR Safe dye (Thermo Fisher Scientific) tovisualize amplifications and confirm negative control. PCR prod- ucts were treated with AMPure XPtoremove unincorporated primers and nucleotides and resuspended in40μlElution Buffer." 638 1274 W2606029971.pdf 9 12 separator 0.95947087 ¶ 1274 1276 W2606029971.pdf 9 13 text 0.9992962 "Toenable pooling oflibraries, Nextera index primers (Illumina) were added following manufacturer's protocol, using 10μlof12SPCR product, 2.5μleach primer, GEIllustra beads with final volume of25μl,and amplification parameters 95ÊC x3m,then 8cycles of(95ÊC x 30s,55ÊC x30s,72ÊC x30s),extension at72ÊC x5m,hold at4ÊC. 5μlofeach reaction were runona2%agarose gelwith SYBR Safe dyetoconfirm amplification." 1276 1686 W2606029971.pdf 9 14 separator 0.9563754 ¶ 1686 1688 W2606029971.pdf 9 15 text 0.99918133 "Indexed PCR products were treated with AMPure XP,resuspended in40μlElution Buffer, and DNA concentration wasdetermined with Qubit. Apooled sample containing 27ngof each library at15nMwassequenced atGENEWIZ onanIllumina MiSeq (2x150bp). Nega- tivelibrary controls asdescribed above were included ineach pool. The 76experimental and 11control libraries, plus samples from other studies notreported here, were analyzed infour MiSeq runs with 35±60 libraries perrun." 1688 2161 W2606029971.pdf 9 16 separator 0.8764659 ¶ 2161 2163 W2606029971.pdf 9 17 text 0.99919695 "Toassess reproducibility, 42DNA samples were re-amplified, indexed, and submitted for MiSeq sequencing, and atwo-way comparison ofeach pair ofamplifications wasperformed." 2163 2336 W2606029971.pdf 9 18 separator 0.757907 ¶ 2336 2338 W2606029971.pdf 9 19 text 0.9983797 "Each taxon detection wasclassified bynumber ofreads and detection ofthat taxon inthe paired sample (S5Table)." 2338 2450 W2606029971.pdf 9 20 separator 0.9929049 ¶ 2450 2452 W2606029971.pdf 9 21 title 0.9733309 Bioinformatics 2452 2467 W2606029971.pdf 9 22 separator 0.99588466 ¶ 2467 2469 W2606029971.pdf 9 23 text 0.99957454 The paired FASTQ files generated bytheMiSeq instrument were analyzed using DADA2 [50]. 2469 2556 W2606029971.pdf 9 24 separator 0.6245916 ¶ 2556 2558 W2606029971.pdf 9 25 text 0.9954546 "DADA2 waschosen because ituses anerror model toinfer exact sample sequences that can vary byaslittle asasingle nucleotide. This isanalternative tocluster-based methods that tradi- tionally lump sequences at3%identity. This technical detail isimportant because the12S amplicon isshort (~100bp notincluding primers) and some fishspecies differ atonly oneora fewnucleotide positions; clustering would potentially lump such taxa together. DADA2 was used tomerge paired FASTQ files and infer sequence variants using thedefault error model parameters, with onemodification. Wechanged thesentence description ofDADA2's error model. The default behavior forDADA2 istobuild anerror model foreach basepair forevery fastq filethat isprovided. Alternatively, youcanbuild anerror model using asubset ofthe total reads from asequencing runand provide thismodel toDADA2. Weused thedefault value and have modified thedescription ofthischoice inthemethods toread asfollows: aDADA2 wasruninaself-consisto mode sothat theerror-model wasindependently built foreach sample. This error model uses FASTQ quality scores toassess thelikelihood ateach Fish eDNA inanurban estuary" 2558 3738 W2606029971.pdf 9 26 separator 0.8872143 ¶ 3738 3740 W2606029971.pdf 9 27 paratext 0.9869836 PLOS ONE |https://doi.or g/10.137 1/journal.po ne.01751 86 April 12,2017 10/15 3740 3819 W2606029971.pdf 9 0 paratext 0.6276435 TABLE 1 | 0 9 W4220874897.pdf 3 1 title 0.84922713 Evidence, best practices, and future direction to improve the care of Young Adults with diabetes in adult care setting. 9 129 W4220874897.pdf 3 2 separator 0.98669887 ¶ 129 131 W4220874897.pdf 3 3 title 0.95057225 The process of transfer from pediatric to adult healthcare systems 131 198 W4220874897.pdf 3 4 separator 0.9460814 ¶ 198 200 W4220874897.pdf 3 5 title 0.75454164 Evidence Best Practices Future Directions 200 242 W4220874897.pdf 3 6 text 0.9593487 " Communication between pediatric and adult care is fragmented “Warm hand-off ”communicated between pediatric and adult care Improve communication between pediatric and adult care –i.e. online registry covering all US states  Current RCT on transfer process have not been effective in improving A1c and number of follow- ups Use of YA coordinator to facilitate transfer and improve clinical attendance Develop tools to assess diabetes knowledge, engagement and progress over time to improve and engage YA in diabetes self-care and clinical attendance  YA have unique psychosocial needs related to their stage of life with several changes in relationship, housing, financial status etc. Assessment of diabetes education and developmental stage to create a diabetes management plan tailored to the YA  Referral to BH when available Develop tools to assess:  Maturation and readiness for transition and engagement" 242 1193 W4220874897.pdf 3 7 table 0.54665184 ¶ 1193 1195 W4220874897.pdf 3 8 text 0.6222927 in diabetes self-care 1195 1217 W4220874897.pdf 3 9 table 0.4936985 1217 1218 W4220874897.pdf 3 10 text 0.47932285 ¶ 1218 1219 W4220874897.pdf 3 11 table 0.4601664 1219 1220 W4220874897.pdf 3 12 text 0.91191095 " Psychosocial needs  Collaborate with behavioral health to support YA during transfer  Create age-speci fic provider competency curriculum to establish trusty relationship and promote engagement" 1220 1424 W4220874897.pdf 3 13 separator 0.98630214 ¶ 1424 1426 W4220874897.pdf 3 14 title 0.938684 Physical Health in in YA with Type 1 diabetesEvidence Best Practices Future DirectionsSuboptimal Glycemic Control 1426 1540 W4220874897.pdf 3 15 text 0.38436568 1540 1541 W4220874897.pdf 3 16 separator 0.45796955 ¶ 1541 1542 W4220874897.pdf 3 17 text 0.9141203 " A1c worsens during YA period  A1c before transition predicts A1c after  High A1c associates with low Health-Related QoL  Socioeconomic disparities impact physical health  Use of diabetes technology may improve glycemic control  Risk of DKA and SH is higher in YA with poor glycemic control Maintenance of clinical attendance with use of program coordinator  Assessment of barriers to engage in" 1542 1965 W4220874897.pdf 3 18 table 0.51550066 ¶ 1965 1967 W4220874897.pdf 3 19 text 0.45471188 diabetes self-care 1967 1986 W4220874897.pdf 3 20 table 0.5404237 ¶  1986 1990 W4220874897.pdf 3 21 text 0.6067867 Assessment of use of diabetes technologies 1990 2033 W4220874897.pdf 3 22 table 0.5976319 ¶ 2033 2036 W4220874897.pdf 3 23 text 0.9196506 " Assessment of social determinants of health  Use of support to establish relationships with speci fic, measurable, achievable, realistic and time-sensitive goals ( SMART )  Discussion of mental health, sex life and alcohol/illicit drug use up front Develop strategies to prevent deterioration of glycemic control and/or prevention of acute complication as severe hypoglycemia and DKA  Validate tools to assess knowledge, readiness and barrier to diabetes management  Increase use, access and engagement with diabetes technology to improve glycemic control  Facilitate and increase access to telehealth/text-messaging  Create peer-to-peer support systems  Develop new learning and engagement software  Reduce racial and socioeconomic gaps in delivery of care among YA" 2036 2844 W4220874897.pdf 3 24 separator 0.9624748 ¶ 2844 2846 W4220874897.pdf 3 25 title 0.94711304 Comorbidities/Complications 2846 2874 W4220874897.pdf 3 26 separator 0.59202707 ¶ 2874 2876 W4220874897.pdf 3 27 table 0.31266052 2876 2877 W4220874897.pdf 3 28 text 0.9244283 " High risk for CVD in T1D  Early onset of T1D is associated with higher CVD risk Screenings for complications and comorbidities  Annual eye exams  Assessment of whether use of ACE-I/ARB and statins is appropriate, primarily based onadult data Develop studies to help stratify YA patients for micro and macro-vascular complications  Assess CVD risk in context of age: impact of age of onset, age-speci fic goal for blood pressure and lipid profile" 2877 3348 W4220874897.pdf 3 29 separator 0.9923122 ¶ 3348 3350 W4220874897.pdf 3 30 title 0.89064705 Evidence Best Practices Future Directions 3350 3392 W4220874897.pdf 3 31 separator 0.64493406 ¶ 3392 3394 W4220874897.pdf 3 32 table 0.5693195  High incidenc 3394 3410 W4220874897.pdf 3 33 text 0.5563053 e of obesity 3410 3422 W4220874897.pdf 3 34 table 0.6287432 ¶ 3422 3425 W4220874897.pdf 3 35 text 0.8218573  High risk for rapid progression and poor 3425 3467 W4220874897.pdf 3 36 table 0.49026072 3467 3468 W4220874897.pdf 3 37 text 0.8591203 "¶ outcomes  Intensive lifestyle and medical intervention have not been ef ficacious  Bariatric surgery is effective for weight and glycemic outcomes" 3468 3625 W4220874897.pdf 3 38 table 0.57747895 ¶ 3625 3628 W4220874897.pdf 3 39 text 0.59381294  High socioeconomic disparities 3628 3660 W4220874897.pdf 3 40 table 0.6057727  Use 3660 3665 W4220874897.pdf 3 41 text 0.58876234 of metformin + 3665 3680 W4220874897.pdf 3 42 table 0.75377125 "GLP-1 RA  Use of intensive lifestyle management  Screening for depression, social determinants of health, eating disorders  Screening for complications and comorbidities Develop ef" 3680 3873 W4220874897.pdf 3 43 text 0.5345649 fica 3873 3877 W4220874897.pdf 3 44 table 0.7085885 "cious lifestyle and medical/surgical interventions  Use SGLT2 inhibitors*  Identify optimal medical treatment vs surgical interventions  Ident" 3877 4032 W4220874897.pdf 3 45 text 0.53757614 ify factors 4032 4043 W4220874897.pdf 3 46 table 0.48117688 to 4043 4046 W4220874897.pdf 3 47 text 0.5020393 predict 4046 4054 W4220874897.pdf 3 48 table 0.62983096 "/stratify patients at higher risk of rapid progression" 4054 4111 W4220874897.pdf 3 49 separator 0.75413454 ¶ 4111 4113 W4220874897.pdf 3 50 table 0.6314687 "Physical health in YA with Type 2 diabetes Evidence Best Practices Future Directions High incidence of obesity  High" 4113 4236 W4220874897.pdf 3 51 text 0.59079903 risk for rapid progression and poor 4236 4272 W4220874897.pdf 3 52 table 0.56798494 "outcomes " 4272 4285 W4220874897.pdf 3 53 text 0.745409 Intensive lifestyle and medical intervention have 4285 4335 W4220874897.pdf 3 54 table 0.5476861 ¶ 4335 4337 W4220874897.pdf 3 55 text 0.66793376 not been ef ficacious 4337 4358 W4220874897.pdf 3 56 table 0.5366147 ¶  4358 4362 W4220874897.pdf 3 57 text 0.82748 Bariatric surgery is effective for weight and 4362 4408 W4220874897.pdf 3 58 table 0.5288437 ¶ 4408 4410 W4220874897.pdf 3 59 text 0.70597553 glycemic 4410 4419 W4220874897.pdf 3 60 table 0.8036172 "outcomes  High socioeconomic disparities Use of metformin + GLP-1 RA  Use of intensive lifestyle management  Screening for depression, social determinants of health, eating disorders  Screening for complications and comorbidities Develop ef ficacious lifestyle and medical/surgical interventions  Use SGLT2 inhibitors *  Identify optimal medical treatment vs surgical interventions  Identify factors to predict /stratify patients at higher risk of rapid progression" 4419 4919 W4220874897.pdf 3 61 separator 0.7417524 ¶ 4919 4921 W4220874897.pdf 3 62 paratext 0.39064997 (Continue 4921 4931 W4220874897.pdf 3 63 text 0.38034678 d 4931 4932 W4220874897.pdf 3 64 paratext 0.7082366 )Toschi et al. Young Adults With Diabetes in Adult Care 4932 4987 W4220874897.pdf 3 65 separator 0.59100527 4987 4988 W4220874897.pdf 3 66 paratext 0.96333796 ¶ Frontiers in Clinical Diabetes and Healthcare | www.frontiersin.org March 2022 | Volume 3 | Article 830183 4 4988 5098 W4220874897.pdf 3 0 paratext 0.9893388 Motriz, Rio Claro, v.21 n.3, p.237-243, July/Sept. 2015 239 0 59 W2286472308.pdf 2 1 separator 0.99063694 ¶ 59 61 W2286472308.pdf 2 2 text 0.7146339 "Nintendo Wii as an adjunct to conventional therapy 360 degrees, 12.Placing alternate foot on step, 13.Standing with one foot in front, 14.Standing on one leg. Each item is scored from 0 to 4, based on the subject’s independence." 61 296 W2286472308.pdf 2 3 separator 0.8310721 ¶ 297 299 W2286472308.pdf 2 4 text 0.98013693 "The total score can range from 0 to 56, with lower scores indicating poorer functioning." 299 391 W2286472308.pdf 2 5 separator 0.9965455 ¶ 391 393 W2286472308.pdf 2 6 title 0.989531 Procedures 393 404 W2286472308.pdf 2 7 separator 0.9950055 ¶ 406 408 W2286472308.pdf 2 8 text 0.99572504 "Participants agreed to attend eleven appointments includ - ing: the experimental rehabilitation program (8), pre-and- post-program assessments (2) and introductory practice (1). The first meeting was set for the pre-program assessment and included data collection with application of clinical in - struments. At the second meeting, subjects were introduced to the clinical setting by creating their personalized avatar and briefly practicing virtual exercises using a Wii Balance Board (WBB). Through appointments three to ten, here called therapy sessions, subjects were submitted to eight 60-minute sessions of an experimental VR-based rehabilita - tion program, held twice a week, for 4 weeks. Each therapy session comprised three phases (therapeutic approaches): kinesiotherapy, virtual reality and learning transfer exercis - es. At the eleventh appointment, clinical instruments were reapplied for post-program assessment. A single investigator performed all assessments." 408 1429 W2286472308.pdf 2 9 separator 0.9970708 ¶ 1429 1431 W2286472308.pdf 2 10 title 0.9910777 Therapy sessions 1431 1448 W2286472308.pdf 2 11 separator 0.99466896 ¶ 1448 1450 W2286472308.pdf 2 12 text 0.99470085 "The first phase of a therapy session involved classic kine - siotherapy for the upper limb during 15 minutes. It included stretching, free exercises, light resistance exercises and postural adjustments followed by joint mobility. The second phase comprised virtual reality exercises for 30 minutes. The setting enclosed a Nintendo Wii console connected to a 29” television and a Wii Balance Board®(WBB), located directly on the floor at a distance of 240 centimeters from the television screen. For safety reasons, a chair and a walker were positioned behind and in front of the WBB, respectively." 1450 2074 W2286472308.pdf 2 13 separator 0.96417546 ¶ 2075 2077 W2286472308.pdf 2 14 text 0.9996156 "The WBB has been validated as a strength platform to assess balance in human research (Brault, Craig, Ferguson, & Young, 2011). It works with the Wii Fit Plus® software, which holds five categories of exercises: strength, yoga, aerobics, balance and advanced training. Seven games (exercises) from the balance category were used in this study. All participants performed the same sequence of games: balance bubble ; penguin slide; soccer heading; tightrope and table tilt , with six minutes of practice for each game." 2077 2619 W2286472308.pdf 2 15 separator 0.970718 ¶ 2620 2622 W2286472308.pdf 2 16 text 0.9978392 "The third phase comprised learning transfer activities (Benda, 2006; Kaefer, Chiviacowsky, Meira, & Go Tani, 2014) for 15 minutes. At this point, participants were asked to per - form real-world exercises that included movements based on those practiced while engaging in virtual reality tasks, such as: straight line walking (resembling Tightrope ) and heading a ball thrown at them by the therapist in various directions (resembling Soccer heading )." 2622 3095 W2286472308.pdf 2 17 title 0.9924289 Adaptation of therapy sessions 3095 3125 W2286472308.pdf 2 18 separator 0.9934287 ¶ 3125 3127 W2286472308.pdf 2 19 text 0.99970454 "Beginning at the fifth therapy session, one out of two extra games ( ski jump and ski slalom) were added to the sequence of virtual games. Simulators of snow sports, these exercises are more challenging and worked as a progression within the treat - ment. They were added alternatively so as to avoid consecutive inclusion in the remaining four sessions. With the addition of a sixth game, the time for each virtual exercise was reduced from six to five minutes, keeping total virtual exposure time in 30 minutes." 3127 3667 W2286472308.pdf 2 20 separator 0.6057346 ¶ 3668 3670 W2286472308.pdf 2 21 text 0.9889777 "All exercises were accomplished without therapeutic or assistive devices. Safety resources were used during the entire intervention, conducted in a laboratory adapted for the study. During therapy sessions, heart rate variability was tracked using a Polar® chest belt HR monitor." 3670 3963 W2286472308.pdf 2 22 separator 0.99686515 ¶ 3963 3965 W2286472308.pdf 2 23 title 0.9916739 Statistical analysis 3965 3986 W2286472308.pdf 2 24 separator 0.9943762 ¶ 3987 3989 W2286472308.pdf 2 25 text 0.99966097 "Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS) 20.0 program, at a 5% significance level. The quantitative variables were described by means and standard deviations. Inferential statistics using Spearman’s correlation determined the association between data measured by both the Berg and FIM scales. Finally, Wilcoxon test verified differences between dependent samples before and after the intervention in order to assess possible effects of motor training with VR and conventional therapy on balance and functionality in the group under study." 3989 4610 W2286472308.pdf 2 26 separator 0.9968903 ¶ 4610 4612 W2286472308.pdf 2 27 title 0.9545213 Results 4612 4620 W2286472308.pdf 2 28 separator 0.995312 ¶ 4620 4622 W2286472308.pdf 2 29 text 0.9971623 "Ten individuals, six men, mean age of 51.4 (± 6.7 years), participated in this study with eight virtual reality-based therapy sessions over the course of four weeks. Before the intervention, the main complaints were insecurity/difficulty in walking or remaining standing independently, reported by all patients. In addition, other problems reported at the initial assessment were hemiparesis (80%), postural patterns (40%) and aphasia (10%). Only 20% had previous experience with video games, either as entertainment or therapy." 4622 5175 W2286472308.pdf 2 30 separator 0.9025421 ¶ 5176 5178 W2286472308.pdf 2 31 text 0.9996055 "Statistical analysis revealed a positive effect of the exercise program based on the final total scores obtained on both scales: FIM ( p = .01) and BERG ( p < .01). FIM outcomes, expressed in Table 1, show an increase in all the items. However, in addition to “total score,” improvements were only significant in three specific tasks: “dressing lower body” ( p = .01), “transfers: bathtub and shower” ( p = .02) and “locomotion: stairs” ( p = .03)." 5178 5648 W2286472308.pdf 2 32 separator 0.8671321 ¶ 5648 5650 W2286472308.pdf 2 33 text 0.99845445 "With respect to balance, Table 2 shows a significant rise in “total score” as well as in six other items: “standing forward with outstretched arm” ( p = .01), “retrieving object from the floor” (p = .04), “turning 360 degrees” ( p = .01), “placing alternate foot on step” ( p = .01), “standing with one foot in front” (p = .01) and “one leg stand” ( p = .03)." 5650 6027 W2286472308.pdf 2 0 paratext 0.9356447 "Jurnal Ius Civile | 5 Volume 6, Nomor 1, Tahun 2022" 0 54 W4281709110.pdf 4 1 separator 0.9858649 ¶ 57 59 W4281709110.pdf 4 2 text 0.99775755 "salah satunya me ngenai kepentingan umum. Dampak dari hukuman tersebut dapat berupa siksaan atau penderitaan bagi yang melanggar nya.9 Dalam kasus ini prositusi online dapat dikatagori kan dalam bagian tindak pidana karena secara tidak langsung memperdagangkan manusia untuk me menuhi kebutuhannya ekonomi dengan cara mel anggar hukum yang telah diterapkan atau bisa dikatakan dengan cara yang tidak benar.10" 59 499 W4281709110.pdf 4 3 separator 0.9087479 ¶ 500 502 W4281709110.pdf 4 4 text 0.99942034 "Dapat diketahui bahwasaannya kejahatan seksual tidak hanya menimpa pada wanita dewasa, bahkan anak-anak di bawah umur juga ikut serta me njadi korbannya. Wa nita kususnya yang masih dibawah umur juga dilibatkan sebagai objek perdaga ngan atau pemuas nafsu bejat dari sese orang atau sekelompok orang tertentu yang menjala nkan bisnis se ksual guna agar m endapat keuntungan ekonomi yang hasilnya bisa berlipat ga nda.11" 502 940 W4281709110.pdf 4 5 separator 0.9763776 ¶ 941 943 W4281709110.pdf 4 6 text 0.9960307 "Berdasarkan hasil wawancara dengan Kapolsek Nagan Raya bapak AK BP Risno mengatakan ada kasus yang meliba tkan anak di bawah umur yang terjadi pada tahun 2021 dan dimuat di media tempat terjadinya kasus tersebut wanita berinisial ZI, 24 tahun. Dia diduga sebagai germo yang menjual seorang wanita berusia 17 tahun seharga Rp 900.000 di sekitarnya. ZI telah menjadi mucikari atau perantara layanan seksual sejak tahun 2020 melalui jejaring sosial WhatsApp, Instagram dan Face book. Aksi ilegal ZI diketahui polisi sehari sebelum ditangkap. Saat itu, tersangka sedang melakukan aksi rayuan dengan memberikan seorang wanita berusia 17 tahun berinisial MS kepada seorang pria. Setelah nego harga dengan MS melalui aplikasi perantara WhatsApp, ZI mengajak wanita tersebut untuk menemui pria tersebut. Saat itu, nasabah memberikan Rp 900.000 atau Rp 500.000 kepada MS, dan Rp 5 00.000 diambil oleh penulis ZI. Sekitar pukul 22.00 WIB pada 7 Novem ber, polisi kemudian menangkap ZI. Saat ini, ZI mendekam di Mapolres Nagan Raya untu k mengusut tuntas prostitusi online milik nya." 943 2116 W4281709110.pdf 4 7 paratext 0.7165357 12 2116 2119 W4281709110.pdf 4 8 separator 0.99378777 ¶ 2120 2122 W4281709110.pdf 4 9 text 0.9918748 "Berdasarkan wawancara dengan bapak Un it Pelayanan Anak dan Perempuan (PPA) Nagan Ra ya, Bapak AKP. Machfud, S.H.,M.M. selaku penyidik perempuan dan a nak yang terlibat dalam isu prostitusi online yang ada dan berbagai tindakan penegakan hukum yang dilakukan, mulai dari penyidikan hingga pemeriksaan penyidikan. Berdasarkan hasil penyidikan Polsek Nagan Raya, pelaku tindak pidana prostitusi online diketahui menggunakan WhatsApp. Klien dapat secara anonim berdagang atau mempekerjakan wanita yang dirujuk di situs jejaring sosial. Dalam kasus prostitusi online di wilayah hukum Polres Nagan Raya, penyidik hampir seca ra e ksklusif mendapat informasi dari masyara kat. Karena keterbatasan penyidik terha dap teknolog i, dalam hal ini penyidik melakukan tindakannya dengan melakukan pengintaian dan kamuflase. Penyidik akan tiba di lokasi yang ditentukan dan menangkap tersangka. 13" 2122 3070 W4281709110.pdf 4 10 separator 0.9938481 ¶ ¶ 3071 3077 W4281709110.pdf 4 11 bibliography 0.9905908 "9 J.B. Daliyo,2002, Pengantar Hukum Indonesia, PT Prenhalindo, Jakarta,hlm.88 10 Soerjono Sokanto, Op.Cit, hlm.25 11 Zainuddin Ali,2010 Filsafat Hukum, Sinar Grafika:Jakarta.hlm.34" 3077 3264 W4281709110.pdf 4 12 separator 0.9839343 ¶ 3265 3267 W4281709110.pdf 4 13 bibliography 0.8981214 12 Hasil Wawancara dengan Kapolres AKBP Risno Nagan Raya 24 November 2021, Pukul 10.21 WIB 3267 3358 W4281709110.pdf 4 14 separator 0.9873912 ¶ 3359 3361 W4281709110.pdf 4 15 bibliography 0.7372986 13 Hasil Wawancara dengan Unit Pelayanan Perempuan dan Anak (PPA) Nagan Raya yaitu bapak AKP. 3361 3469 W4281709110.pdf 4 16 separator 0.95091426 ¶ 3470 3472 W4281709110.pdf 4 17 bibliography 0.96309656 Machfud,S.H.,M.M 24 November 2021, Pukul 11.00 WIB. 3472 3524 W4281709110.pdf 4 0 paratext 0.9836573 RJOAS, 1(85), January 2019 0 26 W2907001643.pdf 7 1 separator 0.7525658 ¶ 28 30 W2907001643.pdf 7 2 paratext 0.9724965 160 30 34 W2907001643.pdf 7 3 text 0.99826145 "Based on the table above shows that the ability to grow crops with polybag media has the highest percentage score of 95.06 with the understanding category. While the ability to grow crops hydroponically has the lowest percentage score of 38.80 in the category less understood." 34 345 W2907001643.pdf 7 4 separator 0.94426656 ¶ 347 349 W2907001643.pdf 7 5 text 0.9985777 "Food independence is the ability of a person or family to produce a variety of food from the home yard. Food independence can guarantee the fulfillment of family food needs to the level of individuals by utilizing the potential of natural, human, social, economic and local spiritual resources in a dignified manner." 349 700 W2907001643.pdf 7 6 separator 0.9907237 ¶ ¶ 702 708 W2907001643.pdf 7 7 title 0.9858246 Table 12 – Distribution of Respondent Based on Family Food Independence 708 786 W2907001643.pdf 7 8 separator 0.89620435 ¶ ¶ 788 794 W2907001643.pdf 7 9 table 0.9556905 "No Classification Percentage of Score % Category 1 Availability of vegetables 49,32 Less 2 Availability of fruits 42,59 Less 3 Availability of cooking ingredients 45,06 Less 4 Availability of medicinal plants 34,56 Less The Average % of Score Achieved 42,88 Less ¶ Source: Processed Data ." 794 1133 W2907001643.pdf 7 10 separator 0.9762848 ¶ ¶ 1134 1140 W2907001643.pdf 7 11 text 0.9995603 "Based on the distribution table of respondents according to family food independence, the percentage of the score of availability of vegetables is 49.32% which is categorized as less, the percentage score in the availability of cooking ingredients is 45.06%, the percentage score for fruit availability is 42.06% and the percentage score in the availability of medicinal plants there is still a lack of independence, which is 34.56%. It could be stated that the variable level of family food independence was categorized as less independent with an average score of 42.88%. Realizing family food independence is not easy, because the people of Banda Aceh City accustomed to getting food from mobile vegetable vendors, nearby kiosks and traditional / supermarket markets to meet their family's daily food needs." 1140 2038 W2907001643.pdf 7 12 separator 0.84545046 ¶ 2040 2042 W2907001643.pdf 7 13 text 0.9993774 "According to them, growing vegetables in the yard is an activity that can add to their daily activities. Because taking care of the household and other work is time consuming as their routine. Even if they want to use the yard, they prefer to plant ornamental plants because they were more easier to maintain without having to do special maintenance every day as well as growing vegetables." 2042 2476 W2907001643.pdf 7 14 separator 0.9828807 ¶ ¶ 2478 2484 W2907001643.pdf 7 15 title 0.99033844 Table 13 – Value of Fit of Models from Factors Affecting KRPL Program Effectiveness in Banda Aceh, 2484 2592 W2907001643.pdf 7 16 separator 0.90861833 ¶ 2594 2596 W2907001643.pdf 7 17 table 0.769925 2018 2596 2601 W2907001643.pdf 7 18 separator 0.7312308 ¶ ¶ 2603 2609 W2907001643.pdf 7 19 table 0.8225155 "Model R R square Adjusted R Square Std. Error Of the Estimate 1 ,805a ,648 ,576 1,26864 ¶ Source: Processed Data . Information. Predictors: (Constant), Fund Assistance (X9), Motivation (X1), Extension Intensity (X7), Land Area (X3), Education (X5), Employment (X6), Partipasi (X2), Applied Innovation (X8), Age (X4)" 2609 2958 W2907001643.pdf 7 20 text 0.98531604 ". ¶ Based on Table 17 it could be seen that the fit of model value is 0.805, this means that 80.5% of this model is relatively appropriate . The remaining 19.5 percent was influenced by other factors. Because this will show an ANOVA table which will assess the value of F table and F count." 2958 3286 W2907001643.pdf 7 21 separator 0.9775735 ¶ ¶ 3287 3293 W2907001643.pdf 7 22 title 0.9094667 Table 14 – Value of Calculations from the KRPL Program Effectiveness 3293 3367 W2907001643.pdf 7 23 table 0.61890006 Model 3368 3377 W2907001643.pdf 7 24 separator 0.7387381 ¶ 3377 3378 W2907001643.pdf 7 25 table 0.981921 "¶ Model Sum of Squares Df Mean Square F Sig. Regression 130,443 9 14,494 9,005 ,000b Residual 70,816 44 1,609 Total 201,259 53 ¶ Source: Processed Data . Information. Predictors: (Constant), Fund Assistance (X9), Motivation (X1), Extension" 3380 3660 W2907001643.pdf 7 26 separator 0.7579746 ¶ 3662 3664 W2907001643.pdf 7 27 table 0.82408965 Intensity (X7), Land Area (X3), Education (X5), Employment (X6), Partipasi (X2), Applied Innovation (X8), Age (X4). 3664 3788 W2907001643.pdf 7 28 separator 0.98157763 ¶ 3789 3791 W2907001643.pdf 7 0 paratext 0.83993363 "This journal is ©the Owner Societies 2015 Phys. Chem. Chem. Phys., 2015, 17, 29747--29752 | 29751ligand plane separation between layers matched that of single crystalline FePc (3.3 Å, CCDC no. 996880), the total distancebetween metal centres would be approximately 3.8 Å, far toolarge for any significant bonding interaction." 0 327 W2166725343.pdf 4 1 separator 0.99518263 ¶ 327 329 W2166725343.pdf 4 2 text 0.9965108 "The ability to position the metal atoms of metal phthalocyanine multilayers directly above each other may have significantimplications for control of their properties. One prominent example of this is the predicted enhancement of magnetic exchange interactions in metal phthalocyanine thin films 36if the distances between their metal centres can be reduced andangles between them controlled. Although our data onlyaddresses growth in the monolayer regime, this methodologycould have significant implications for final property control." 329 876 W2166725343.pdf 4 3 separator 0.9972128 ¶ 876 878 W2166725343.pdf 4 4 title 0.9921875 Conclusions 878 890 W2166725343.pdf 4 5 separator 0.99620897 ¶ 890 892 W2166725343.pdf 4 6 text 0.9996029 "In conclusion, a combination of STM imaging and LEED hasbeen applied to the growth of a non-planar/planar phthalo-cyanine bilayer system on Au(111). The combination of thesetwo methods has allowed us to establish the true orientation and size of the surface mesh of the initial monolayer of FePc on Au(111), showing that the structure is incommensurate, andnot commensurate as previously proposed. Both methods alsoshow that sub-monolayer islands of VOPc grow on this FePcmonolayer with exact (1 /C21) periodicity, but STM also shows that the individual VOPc molecules sit directly atop FePcmolecules, a behaviour quite unlike that seen in the growthof single metal phthalocyanine films. The appearance of the STM images of the VOPc molecules is consistent with those recorded in pure VOPc growth that have been attributed tomolecules in which the V QO species points down into the surface. Of course, this kind of STM ‘image fingerprinting’ fallswell short of a true quantitative structural conclusion. However,the on-top configuration, together with the lack of mobilityeven at room temperature, strongly implies that there is a significant direct bonding interaction between the two moleculesthat can only be reasonably understood in this V QO-down orientation such that Fe–O bond can be formed." 892 2207 W2166725343.pdf 4 7 separator 0.9970236 ¶ 2207 2209 W2166725343.pdf 4 8 title 0.9866824 Acknowledgements 2209 2226 W2166725343.pdf 4 9 separator 0.99555373 ¶ 2226 2228 W2166725343.pdf 4 10 text 0.9967104 AJR and SH acknowledge support from the Engineering andPhysical Sciences Research Council (EPSRC), UK (Grant no. EP/G037515/1). LAR and TSJ acknowledge support from theEPSRC, UK (Grant no. EP/H021388/1). The underlying datafor this manuscript are freely available from the followingDOI: 10.6084/m9.figshare.1574110. 2228 2544 W2166725343.pdf 4 11 separator 0.9959949 ¶ 2544 2546 W2166725343.pdf 4 12 title 0.8170382 References 2546 2557 W2166725343.pdf 4 13 separator 0.9898559 ¶ 2557 2559 W2166725343.pdf 4 14 bibliography 0.9817793 "1 S. R. Forrest, Nature , 2004, 428, 911. 2 H. Spanggaard and F. C. Krebs, Sol. Energy Mater. Sol. Cells , 2004, 83, 125." 2559 2685 W2166725343.pdf 4 15 separator 0.63924694 ¶ 2685 2687 W2166725343.pdf 4 16 bibliography 0.99779946 3 K. Leo, Nat. Photonics , 2011, 5, 716. 2687 2728 W2166725343.pdf 4 17 separator 0.8619152 ¶ 2728 2730 W2166725343.pdf 4 18 bibliography 0.99801135 "4 Q. Tang, H. Li, Y. Liu and W. Hu, J. Am. Chem. Soc. , 2006, 128, 14634." 2730 2806 W2166725343.pdf 4 19 separator 0.87495345 ¶ 2806 2808 W2166725343.pdf 4 20 bibliography 0.9976989 5 C. G. Claessens, U. Hahn and T. Torres, Chem. Rec. , 2008, 8,7 5 . 2808 2877 W2166725343.pdf 4 21 separator 0.88841856 ¶ 2877 2879 W2166725343.pdf 4 22 bibliography 0.9979568 "6 L. A. Rochford, A. J. Ramadan, S. Heutz and T. S. Jones, Phys. Chem. Chem. Phys. , 2014, 16, 25404." 2879 2983 W2166725343.pdf 4 23 separator 0.89133614 ¶ 2983 2985 W2166725343.pdf 4 24 bibliography 0.99790514 "7 W. Wu, L. a. Rochford, S. Felton, Z. Wu, J. L. Yang, S. Heutz, G. Aeppli, T. S. Jones, N. M. Harrison and a. J. Fisher, J. Appl. Phys. , 2013, 113, 013914." 2985 3147 W2166725343.pdf 4 25 separator 0.9154098 ¶ 3147 3149 W2166725343.pdf 4 26 bibliography 0.9979714 "8 L. A. Rochford, D. S. Keeble, O. J. Holmes, G. J. Clarkson and T. S. Jones, J. Mater. Chem. C , 2014, 2, 6056." 3149 3264 W2166725343.pdf 4 27 separator 0.93679667 ¶ 3264 3266 W2166725343.pdf 4 28 bibliography 0.9978101 "9 M. Riede, C. Uhrich, J. Widmer, R. Timmreck, D. Wynands, G. Schwartz, W.-M. Gnehr, D. Hildebrandt, A. Weiss,J. Hwang, S. Sundarraj, P. Erk, M. Pfeiffer and K. Leo, Adv. Funct. Mater. , 2011, 21, 3019." 3266 3472 W2166725343.pdf 4 29 separator 0.98520684 ¶ 3472 3474 W2166725343.pdf 4 30 caption 0.9932346 "Fig. 5 Schematic diagram showing the local registry of adjacent molecules in successive layers of bulk crystalline FePc (a) and VOPc (b), and the two alternative atop geometries of VOPc on FePc (c and d). In the lower panels the VOPc conformation is assumed to be the same as in the bulk crystalline material. In the case of the VOPc ‘down’ geometry, there may well be changes in the buckling of the ligand plane and the separation of the V and O atoms out of the ligand plane.PCCP Paper" 3474 3968 W2166725343.pdf 4 31 separator 0.8571516 ¶ 3968 3970 W2166725343.pdf 4 32 paratext 0.9575293 "Open Access Article. Published on 12 October 2015. Downloaded on 5/18/2024 3:36:29 AM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. View Article Online" 3970 4170 W2166725343.pdf 4 0 paratext 0.98586756 "Revista de Letras Norte@mentos Estudos Linguísticos, Sinop, v. 15, n. 39 , p.105-125, jul./dez. 2022 . 110" 0 159 W4361858007.pdf 5 1 text 0.99190784 "reconfigurado por Barros (2012b), que distingue, nele, uma fase preliminar : a construção de um modelo teóric o, que compreende o estabelecimento de características do gênero estudado enquanto objeto social de referência ." 159 391 W4361858007.pdf 5 2 separator 0.9375043 ¶ 393 395 W4361858007.pdf 5 3 text 0.99946123 "É nesse sentido que Barros (2012b, p. 15) acredita que “o modelo do gênero pode ser visto, a priori , apenas teoricamente, isto é, sua construção não necessitaria levar em conta as capacidades dos alunos nem as parti cularidades do contexto de ensino” . Ou seja, o modelo teórico seria o primeiro movimento no processo de transposição didática (CHEVALLARD , 2013) do gênero, uma vez que torna explícito o seu funcionamento (contextual, discursivo, linguístico) dentro da sua esfera social de base. Segundo Barros (2012b, p. 15)," 396 945 W4361858007.pdf 5 4 separator 0.9140536 ¶ ¶ 947 953 W4361858007.pdf 5 5 text 0.9965299 "[...] ele [o modelo teórico] vem sendo elaborado por vários pesquisadores que, ao descrever os conhecimentos subjacentes aos mais variados gêneros, elaboram uma ferramenta fundamentalmente teórica, cujo objetivo é servir de base para ações didáticas posteriores em um eventual processo de transposição didática." 953 1277 W4361858007.pdf 5 6 separator 0.9555231 ¶ ¶ 1279 1285 W4361858007.pdf 5 7 text 0.99949557 "Compreendemos, assim, o modelo teórico como uma ferramenta que auxilia o professor a compreender o gênero, antes d e se pensar propriamente em um contexto de ensino específico . É uma forma de conhecê -lo enquanto objeto social /teórico, explicitar as suas especificidades, antes d a modeliza ção didática de suas dimensões ensináveis , as quais estão condicionadas, como expli ca Machado e Cristovão (2006), à observação do contexto e das capacidades de linguagem dos alunos onde se pretende realizar um determinado projeto de ensino." 1286 1846 W4361858007.pdf 5 8 separator 0.9786671 ¶ 1848 1850 W4361858007.pdf 5 9 text 0.9993119 "O cotejamento de diferentes modelos de gêneros pode , segundo Machado e Cristovão (2006, p. 552 – grifos das autoras ), “nos fornecer pistas para encontrarmos semelhanças e/ou diferenças que podemos não perceber de início, o que levaria a reformular os ‘modelos de gêneros’ ou os ‘gêneros teóricos’ inicialmente construídos”." 1851 2188 W4361858007.pdf 5 10 separator 0.9528033 ¶ 2189 2191 W4361858007.pdf 5 11 text 0.99943775 "Isso porque um modelo teórico, assim como seu gênero de referência, sofre influências do contexto sócio -histórico, o que nos leva a compreendê -lo como um instrumento maleável e mutável . Ou seja, um modelo do gênero deve ser visto, sempre, como representant e de uma prática social de linguagem que, como já ressaltamos, está condicionada a variações e mudanças." 2191 2568 W4361858007.pdf 5 12 separator 0.95764345 ¶ 2571 2573 W4361858007.pdf 5 13 text 0.9987127 "Na nossa pesquisa, a modelização teórica da carta de reclamação é direcionada para a análise da funcionalidade do gênero, sob a ótica das capacidade s de linguagem" 2574 2741 W4361858007.pdf 5 0 paratext 0.9588019 "UNDERGRADUATE RESEARCH IN NATURAL AND CLINICAL SCIENCE AND TECHNOLOGY (URNCST) JOURNAL Read more URNCST Journal articles and submit your own today at: https://www.urncst.com ¶ Dhall et al. | URNCST Journal (2021): Volume 5, Issue 6 Page 5 of 9 DOI Link : https://doi.org/10.26685/urncst.261" 0 307 W3170318892.pdf 4 1 text 0.9989114 "but the former does not give the same effectivity rate as platinum [44] and ferricyanide despite generating 1.5 -1.8 times more power than platinum, needs to be generated chemically [29]. Other cathodes using iron and cobalt as organic mixtures may replace platinum, but their durability is not well studied [45]. The hypothetical device should use graphite rods [34] making the device more c ost-effective as graphite is cheaper and generates a high amount of electricity [37]." 308 811 W3170318892.pdf 4 2 separator 0.97807693 ¶ 813 815 W3170318892.pdf 4 3 text 0.99972796 "Normal batteries in remotes for example, could also be used as they are simple to put in the device. However, once these batteries run out, they need to be charged. If the diagnostic device is being used in third world countries, then having access to electricity is not very common. MFC's, unlike batteries, do not need to store electrical energy as they can directly create it [46] by using saliva, for example. This process has a higher efficiency rate of 40% to 60% whereas batteries have an efficiency rate of less than 40% [46]. Like normal batteries, saliva can also be stored for longer periods of time. If optimal levels of humidity and temperature are maintained, a bio -battery can elicit a constant power density output of 0.396 μW/cm^2 [20] whereas, MFCs generate 1540 mW/m^2 [29] power density, ther eby releasing more power for the device. As in Figure 1 , the MFC will have PEDOT:PSS as the semiconductor surrounding it which will increase the power output of the device by doping. The level of doping increases with the progression of miniaturization [4]. It can be noted that an MFC is a small cell; it would require a significantly increased level of PEDOT:PSS doping. As doping levels of PEDOT:PSS increase, it is anticipated that the overall conductivity of the MFC should increase as well." 815 2195 W3170318892.pdf 4 4 separator 0.98393774 ¶ 2197 2199 W3170318892.pdf 4 5 text 0.9997037 "MFC’s use bacteria that break down organic matter like saliva to create ele ctricity [29]. Protons flow from the anode to the cathode once the bacteria produces protons by breaking down the organic matter [29]. The hypothetical device created in Figure 1 uses a similar method where an anode and cathode will be divided by a Nafion membrane [34] and the device will use bacteria to break down saliva and produce protons to create a current. The flow of protons will be connected to the diagnostic device attached which will be diagnosing the saliva from the peristaltic pump." 2199 2802 W3170318892.pdf 4 6 separator 0.8808825 ¶ 2803 2805 W3170318892.pdf 4 7 text 0.99970096 "Simultaneously, the flow of protons will also power the monitor displaying the results. The hypothetical device will be able to use saliva’s chemical ability to fuel the MFC powering the diagnostic device. The hypothetical device would be an improved version of the MFC by Logan et al.’s [29] and Mansoorian et al.’s [34] as it will be able to diagnose the person while using their saliva to generate the power to do so." 2805 3248 W3170318892.pdf 4 8 separator 0.9327309 ¶ 3251 3253 W3170318892.pdf 4 9 text 0.99970186 "Although the electrical component of the hypothetical device is c heaper, adding the diagnostic device raises the cost of the whole device. A monitor to display the results of the diagnoses will also increase the overall cost of the device." 3253 3503 W3170318892.pdf 4 10 separator 0.87429404 ¶ 3504 3506 W3170318892.pdf 4 11 text 0.9995599 "The diagnostic device will only be able to give baseline values which have to be analysed by the medical professional and to actually give medication and treatment to the patient, further tests and treatments need to be carried out to improve the patient’s well -being." 3506 3785 W3170318892.pdf 4 12 separator 0.9486044 ¶ 3788 3790 W3170318892.pdf 4 13 text 0.9996607 "Using saliva as a fuel source can be expanded to larger scale devic es theoretically, where under optimal conditions singular MFCs can be combined into a circuit to generate power for outdoor lighting. This supposed MFC could also contain 2 electrodes: an anode, as well as an air -cathode [31]." 3790 4098 W3170318892.pdf 4 14 separator 0.7479054 ¶ 4099 4101 W3170318892.pdf 4 15 text 0.9996556 "The carbon anodes could be connected to sewage systems providing a natural flow of bacteria to treat the MFC before the saliva is introduced [31]. A creative use for such a system is by utilizing spit, and dog saliva to produce electricity in third world countries such as India. In stray dogs’ salivation can be caused by many factors like the scent of food, or other biological problems [47]. Although canine saliva may have different components, the MFC can be tested to see if dog saliva is as effective as humans." 4101 4645 W3170318892.pdf 4 16 separator 0.972619 ¶ 4648 4650 W3170318892.pdf 4 17 text 0.99974877 "As WHO stated that 50% of the world doesn’t have access to basic healthcare necessities, using freeze -dried cells and MFC’s as in Figure 1 , in medical devices and using saliva to generate power will be cost efficient. For example, in a dentist’s office, a saliva ejector is used to suction out the saliva which can be collected and used to power the same device and other devices such as the cavitron (a device that cleans plaque from the teeth [48]). It has been shown that saliva can be used to power a LED for 20 minutes [49]. This is espe cially useful in low -income countries where cheaper sources of electricity are beneficial. Instead of the government or private institutions sending medical equipment yearly to treat lower -income households , the hypothetical device can be used for diagnosi s." 4650 5499 W3170318892.pdf 4 18 separator 0.9941549 ¶ ¶ 5501 5507 W3170318892.pdf 4 19 title 0.98923236 Conclusions 5507 5519 W3170318892.pdf 4 20 separator 0.9928396 ¶ 5521 5523 W3170318892.pdf 4 21 text 0.99972975 "Healthcare worldwide can be made better by initiating adequate diagnosis procedures to prevent the spread of disease, providing small scale lighting and electricity to healthcare facilities and communities. In theory, since saliva is capab le of exoelectrogenic lyophilization for point of care diagnostics and is a non -invasive biofluid with efficiency to power a semiconductor for a MFC, a device can be designed for simultaneous functions of power generation using saliva as the fuel source, a nd diagnosis. The intent of the research protocol was to explore the use of saliva as a fuel source to power diagnostic POC devices. It is anticipated that this prototype can use saliva to generate power to assist developing countries with primary POC diag nosis. The hypothetical prototype uses the knowledge from previous devices and improves and combines the functions of semiconducting and diagnostic devices. The importance of the research protocol is to improve electricity and healthcare sustainability as well as reduce the problems faced by people in developing nations by creating a self -powered diagnostic device. The protocol also combines the scientific knowledge presented in other research, enhancing, and promoting questions that can be associated with semiconductors. A fuel source brings in the aspect of the natural sciences, by using" 5523 6942 W3170318892.pdf 4 0 table 0.9861945 "/0 /1 /2 /1 /3 /4 /5 /6 □ /8 /9 □ /10 /11 /12 /3 /9 /13 /14 /13 /1 /2 □ /3 /9 /15 □ /16 /8 /5 /13 /3 /17 □ /16 /5 /13 /1 /9 /5 /1 /2 □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ □ /18 /18 /18 /19 /13 /13 /2 /14 /1 /19 /8 /4 /20 □ /21 /16 /16 /22 □ /23 /23 /23 /24 /25 /26 /27 /28 /28 □ /29 /30 /3 /31 /1 /4 /32 □ □ □ /21 /16 /16 /22 □ /23 /23 /23 /26 /25 /33 /24 /34 /24 □ /29 /35 /9 /17 /13 /9 /1 /32 □ □ /36 /8 /17 /19 /37 /38 /39 □ /22 /8 /19 /37 /23 /39 □ /23 /33 /23 /38 □ □ /26 /40 □ /15 /13 /2 /14 /4 /13 /5 /14 □ /4 /3 /9 /41 /1 /15 □ /3 /12 /8 /9 /20 □ /14 /6 /1 □ /42 /8 /14 /14 /8 /12 □ /15 /13 /2 /14 /4 /13 /5 /14 /2 □ /13 /9 □ /43 /3 /9 /44 /3 /9 /13 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/28 /101 /32 □ /8 /46 □ /4 /1 /2 /31 /8 /9 /15 /1 /9 /14 /2 □ /2 /14 /4 /8 /9 /20 /17 /47 □ /3 /20 /4 /1 /1 /15 □ /14 /8 □ /6 /3 /76 /1 □ /3 /15 /1 /77 /11 /3 /14 /1 □ /2 /14 /11 /15 /47 /13 /9 /20 □ /14 /13 /12 /1 □ /3 /14 □ /6 /8 /12 /1 /19 □ /21 /9 □ /98 /6 /3 /4 /13 /14 /47 □ /99 /18 /1 /100 /11 /11 □ /2 /1 /5 /8 /9 /15 /3 /4 /47 □ /2 /5 /6 /8 /8 /17 □ /38 /24 □ /29 /26 /33 /19 /27 /24 /101 /32 □ /8 /46 □ /4 /1 /2 /31 /8 /9 /15 /1 /9 /14 /2 □ /2 /14 /4 /8 /9 /20 /17 /47 □ /3 /20 /4 /1 /1 /15 □ /14 /8 □ /6 /3 /76 /1 □ /3 /15 /1 /77 /11 /3 /14 /1 □ /14 /13 /12 /1 □ /46 /8 /4 □ /2 /14 /11 /15 /47 /13 /9 /20 □ /3 /14 □ /6 /8 /12 /1 □ /31 /17 /3 /5 /1 /2 /19 □ □ /43 /6 /1 /13 /4 □ /4 /1 /2 /11 /17 /14 /2 □ /13 /9 /15 /13 /5 /3 /14 /1 □ /76 /3 /4 /47 /13 /9 /20 □ /17 /1 /76 /1 /17 /2 □ /8 /46 □ /13 /9 /46 /17 /11 /1 /9 /5 /1 □ /8 /46 □ /14 /13 /12 /1 □ /8 /9 □ /17 /1 /3 /4 /9 /1 /4 /2 □ /18 /13 /14 /6 □ /96 /3 /41 /11 /9 /15 /11 /5 /6 /13 □ /6 /8 /17 /15 /13 /9 /20 □ /38 /19 /38 □ /13 /9 /15 /13 /5 /3 /14 /13 /9 /20 □ /3 □ /12 /8 /15 /1 /4 /3 /14 /1 □ /17 /1 /76 /1 /17 □ /8 /46 □ /13 /9 /46 /17 /11 /1 /9 /5 /1 /19 □ /97 /3 /12 /42 /13 /3 /9 /13 □ /6 /8 /17 /15 /2 □ /38 /19 /38 □" 0 17188 W4383378282.pdf 6 0 caption 0.97216916 Fig. 3 (See legend on next page.) 0 33 W3129753562.pdf 7 1 paratext 0.95316935 Liet al. Journal of Experimental & Clinical Cancer Research (2021) 40:210 Page 8 of 17 33 128 W3129753562.pdf 7 0 paratext 0.9848608 Pathogens 2023 ,12, 44 17 of 18 0 31 W4313328179.pdf 16 1 separator 0.9878951 ¶ 31 33 W4313328179.pdf 16 2 bibliography 0.99801666 "14. Goldfarb, T.; Sberro, H.; Weinstock, E.; Cohen, O.; Doron, S.; Charpak-Amikam, Y.; Afik, S.; Ofir, G.; Sorek, R. BREX is a novel phage resistance systemwidespread in microbial genomes. EMBO J. 2015 ,34, 169–183. [CrossRef]" 33 260 W4313328179.pdf 16 3 separator 0.93986833 ¶ 260 262 W4313328179.pdf 16 4 bibliography 0.9976971 "15. Manni, M.; Berkeley, M.R.; Seppey, M.; Sim ão, F.A.; Zdobnov, E.M. BUSCO Update: Novel and Streamlined Workflows along with Broader and Deeper Phylogenetic Coverage for Scoring of Eukaryotic, Prokaryotic, and Viral Genomes. Mol. Biol. Evol. 2021 , 38, 4647–4654. [CrossRef]" 262 543 W4313328179.pdf 16 5 separator 0.94960964 ¶ 543 545 W4313328179.pdf 16 6 bibliography 0.9978666 "16. Page, A.J.; Cummins, C.A.; Hunt, M.; Wong, V .K.; Reuter, S.; Holden, M.T.G.; Fookes, M.; Falush, D.; Keane, J.A.; Parkhill, J. Roary: Rapid large-scale prokaryote pan genome analysis. Bioinformatics 2015 ,31, 3691–3693. [CrossRef]" 545 783 W4313328179.pdf 16 7 separator 0.90976936 ¶ 783 785 W4313328179.pdf 16 8 bibliography 0.997729 "17. Katoh, K.; Standley, D.M. MAFFT multiple sequence alignment software version 7: Improvements in performance and usability. Mol. Biol. Evol. 2013 ,30, 772–780. [CrossRef]" 785 961 W4313328179.pdf 16 9 separator 0.88841426 ¶ 961 963 W4313328179.pdf 16 10 bibliography 0.9980122 "18. Price, M.N.; Dehal, P .S.; Arkin, A.P . FastTree 2—Approximately maximum-likelihood trees for large alignments. PLoS ONE 2010 , 5, e9490. [CrossRef]" 963 1118 W4313328179.pdf 16 11 separator 0.8932283 ¶ 1118 1120 W4313328179.pdf 16 12 bibliography 0.99809676 "19. Arndt, D.; Grant, J.; Marcu, A.; Sajed, T.; Pon, A.; Liang, Y.; Wishart, D.S. PHASTER: A better, faster version of the PHAST phage search tool. Nucleic Acids Res. 2016 ,44, W16–W21. [CrossRef]" 1120 1319 W4313328179.pdf 16 13 separator 0.8321363 ¶ 1319 1321 W4313328179.pdf 16 14 bibliography 0.99805105 20. Seemann, T. Prokka: Rapid prokaryotic genome annotation. Bioinformatics 2014 ,30, 2068–2069. [CrossRef] 1321 1429 W4313328179.pdf 16 15 separator 0.8724458 ¶ 1429 1431 W4313328179.pdf 16 16 bibliography 0.9980806 "21. Jang, B.H.; Bolduc, B.; Zablocki, O.; Kuhn, J.H.; Roux, S.; Adriaenssens, E.M.; Brister, J.R.; Kropinski, A.M.; Krupovic, M.; Lavigne, R.; et al. Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks. Nat. Biotechnol. 2019 ,37, 632–639. [CrossRef] [PubMed]" 1431 1741 W4313328179.pdf 16 17 separator 0.9247029 ¶ 1741 1743 W4313328179.pdf 16 18 bibliography 0.99813795 "22. Pons, J.C.; Paez-Espino, D.; Riera, G.; Ivanova, N.; Kyrpides, N.C.; Llabr és, M. VPF-Class: Taxonomic assignment and host prediction of uncultivated viruses based on viral protein families. Bioinformatics 2021 ,37, 1805–1813. [CrossRef] [PubMed]" 1743 1996 W4313328179.pdf 16 19 separator 0.89933926 ¶ 1996 1998 W4313328179.pdf 16 20 bibliography 0.9980464 "23. Moraru, C.; Varsani, A.; Kropinski, A.M. VIRIDIC—A Novel Tool to Calculate the Intergenomic Similarities of Prokaryote- Infecting Viruses. Viruses 2020 ,12, 1268. [CrossRef] [PubMed]" 1998 2187 W4313328179.pdf 16 21 separator 0.9172199 ¶ 2187 2189 W4313328179.pdf 16 22 bibliography 0.99783254 24. Wickham, H. ggplot2: Elegant Graphics for Data Analysis ; Springer: New York, NY, USA, 2016; ISBN 978-3-319-24277-4. 2189 2310 W4313328179.pdf 16 23 separator 0.9439266 ¶ 2310 2312 W4313328179.pdf 16 24 bibliography 0.9979606 "25. Couvin, D.; Bernheim, A.; Toffano-Nioche, C.; Touchon, M.; Michalik, J.; N éron, B.; Rocha, E.P .C.; Vergnaud, G.; Gautheret, D.; Pourcel, C. CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins. Nucleic Acids Res. 2018 ,46, W246–W251. [CrossRef] [PubMed]" 2312 2655 W4313328179.pdf 16 25 separator 0.9438242 ¶ 2655 2657 W4313328179.pdf 16 26 bibliography 0.9981013 "26. Benson, D.A.; Cavanaugh, M.; Clark, K.; Karsch-Mizrachi, I.; Lipman, D.J.; Ostell, J.; Sayers, E.W. GenBank. Nucleic Acids Res. 2013 ,41, 36–42. [CrossRef]" 2657 2819 W4313328179.pdf 16 27 separator 0.89523506 ¶ 2819 2821 W4313328179.pdf 16 28 bibliography 0.99781275 "27. Roux, S.; P áez-Espino, D.; Chen, I.M.A.; Palaniappan, K.; Ratner, A.; Chu, K.; Reddy, T.; Nayfach, S.; Schulz, F.; Call, L.; et al. IMG/VR v3: An integrated ecological and evolutionary framework for interrogating genomes of uncultivated viruses. Nucleic Acids Res. 2021 ,49, D764–D775. [CrossRef]" 2821 3127 W4313328179.pdf 16 29 separator 0.9210795 ¶ 3127 3129 W4313328179.pdf 16 30 bibliography 0.99803066 "28. Parcey, M.; Gayder, S.; Morley-Senkler, V .; Bakkeren, G.; Úrbez-Torres, J.R.; Ali, S.; Castle, A.J.; Svircev, A.M. Comparative genomic analysis of Erwinia amylovora reveals novel insights in phylogenetic arrangement, plasmid diversity, and streptomycin resistance. Genomics 2020 ,112, 3762–3772. [CrossRef]" 3129 3445 W4313328179.pdf 16 31 separator 0.9046967 ¶ 3445 3447 W4313328179.pdf 16 32 bibliography 0.9980154 "29. Koskella, B.; Brockhurst, M.A. Bacteria-phage coevolution as a driver of ecological and evolutionary processes in microbial communities. FEMS Microbiol. Rev. 2014 ,38, 916–931. [CrossRef]" 3447 3641 W4313328179.pdf 16 33 separator 0.89953315 ¶ 3641 3643 W4313328179.pdf 16 34 bibliography 0.99801296 "30. Almpanis, A.; Swain, M.; Gatherer, D.; McEwan, N. Correlation between bacterial G+C content, genome size and the G+C content of associated plasmids and bacteriophages. Microb. Genom. 2018 ,4, e000168. [CrossRef]" 3643 3861 W4313328179.pdf 16 35 separator 0.8833077 ¶ 3861 3863 W4313328179.pdf 16 36 bibliography 0.9963193 "31. Pratama, A.A.; Bolduc, B.; Zayed, A.A.; Zhong, Z.; Guo, J.; Vik, D.R.; Gazit úa, M.C.; Wainaina, J.M.; Roux, S.; Sullivan, M.B. Expanding standards in viromics: In silico evaluation of dsDNA viral genome identification, classification, and auxiliary metabolic gene curation. PeerJ 2021 ,9, e11447. [CrossRef]" 3863 4178 W4313328179.pdf 16 37 separator 0.8943018 ¶ 4178 4180 W4313328179.pdf 16 38 bibliography 0.9979466 "32. Kieft, K.; Zhou, Z.; Anantharaman, K. VIBRANT: Automated recovery, annotation and curation of microbial viruses, and evaluation of viral community function from genomic sequences. Microbiome 2020 ,8, 90. [CrossRef] [PubMed]" 4180 4410 W4313328179.pdf 16 39 separator 0.9170114 ¶ 4410 4412 W4313328179.pdf 16 40 bibliography 0.99797267 "33. Roux, S.; Krupovic, M.; Daly, R.A.; Borges, A.L.; Nayfach, S.; Schulz, F.; Sharrar, A.; Carnevali, P .B.M.; Cheng, J.F.; Ivanova, N.N.; et al. Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth’s biomes. Nat. Microbiol. 2019 , 4, 1895–1906. [CrossRef] [PubMed]" 4412 4708 W4313328179.pdf 16 41 separator 0.94548345 ¶ 4708 4710 W4313328179.pdf 16 42 bibliography 0.9979912 "34. Andrade-Dom ínguez, A.; Kolter, R.; Shapiro, L.R. Complete Genome Sequence of EtG, the First Phage Sequenced from Erwinia tracheiphila .Genome Announc. 2018 ,6, e00127-18. [CrossRef] [PubMed]" 4710 4908 W4313328179.pdf 16 43 separator 0.91419065 ¶ 4908 4910 W4313328179.pdf 16 44 bibliography 0.9978653 "35. Fontana, R.; Macchi, G.; Caproni, A.; Sicurella, M.; Buratto, M.; Salvatori, F.; Pappad à, M.; Manfredini, S.; Baldisserotto, A.; Marconi, P . Control of Erwinia amylovora Growth by Moringa oleifera Leaf Extracts: In Vitro and in Planta Effects. Plants 2022 , 11, 957. [CrossRef] [PubMed]" 4910 5207 W4313328179.pdf 16 45 separator 0.9493706 ¶ 5207 5209 W4313328179.pdf 16 46 bibliography 0.9978994 "36. Shapiro, L.R.; Paulson, J.N.; Arnold, B.J.; Scully, E.D.; Zhaxybayeva, O.; Pierce, N.E.; Rocha, J.; Klepac-Ceraj, V .; Holton, K.; Kolter, R. An introduced crop plant is driving diversification of the virulent bacterial pathogen Erwinia tracheiphila .MBio Ecol. Evol. Sci. 2018 ,9, e01307-18. [CrossRef]" 5209 5520 W4313328179.pdf 16 47 separator 0.93707037 ¶ 5520 5522 W4313328179.pdf 16 48 bibliography 0.9980398 "37. Borruso, L.; Salomone-Stagni, M.; Polsinelli, I.; Schmitt, A.O.; Benini, S. Conservation of Erwinia amylovora pathogenicity-relevant genes among Erwinia genomes. Arch. Microbiol. 2017 ,199, 1335–1344. [CrossRef]" 5522 5740 W4313328179.pdf 16 49 separator 0.9184103 ¶ 5740 5742 W4313328179.pdf 16 50 bibliography 0.99728924 "38. Bondy-Denomy, J.; Davidson, A.R. When a virus is not a parasite: The beneficial effects of prophages on bacterial fitness. J. Microbiol. 2014 ,52, 235–242. [CrossRef]" 5742 5913 W4313328179.pdf 16 0 title 0.96969557 Intrudction 0 11 W3106676101.pdf 1 1 separator 0.9954649 ¶ 11 13 W3106676101.pdf 1 2 text 0.9993124 "Recent COVID-19 (Coronavirus Disease 2019) caused by a novel coronavirus named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) has been spread fastly all over the world. Higher lethality and powerful human-to-human transmission capacity has aroused widely concern. As a kind of enveloped virus with single- stranded positive-sensed RNA, new SARS2 CoV (Coronavirus) is a member of CoV family, which has closer relationship to previous SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome) CoVs [1,2]." 13 571 W3106676101.pdf 1 3 separator 0.97314084 ¶ 571 573 W3106676101.pdf 1 4 text 0.99962884 "Coronaviruses are cataloged into the Nidovirales, Cornidovirineae, Orthocoronavirinae and divided into four Genuses. Until now, the Alpha-coronavirus and Beta-coronavirus response to known human-isolated CoVs (HCoVS), including the above three CoVs combined with HKU1, OC43, NL63 and 229E HCoVs. According to phylogenetic analysis, these HCoVs are considered to have originated from the bats and rodents [3-5]. The genomes of coronaviruses have been described meticulously in previous reports. As one of biggest viruses, the 5’-terminal of positive-sense and single-stranded RNA (+ssRNA) genome in coronavirus encodes a polyprotein complexus, pp1ab, while the 3’-terminal encodes the structural proteins, such as the envelope glycoprotein spike protein (S-protein), envelope (E), membrane (M), nucleocapsid (N) and possible hemagglutinin-esterase (HE)[6-7]." 573 1452 W3106676101.pdf 1 5 separator 0.9703847 ¶ 1452 1454 W3106676101.pdf 1 6 text 0.999534 The clove homotrimeric S-protein is a type I glycoprotein which gives the crown-like appearance on CoVs. 1454 1559 W3106676101.pdf 1 7 separator 0.9461764 ¶ 1560 1562 W3106676101.pdf 1 8 text 0.99943054 "The S1 and S2 subunits in S-protein monomer, are responsible for cell binding and membrane fusion, respectively [8]. The S1 subunit forms the globular head and contains the N-terminal domain (NTD), receptor binding domain (RBD) and smaller subdomains (SD1 and SD2). The S2 subunit is conserved among all coronaviruses and forms the main rosette-like α-helix bundle and a β-sheets-riched subdomain. In the endosome, the S2 could be further cleaved by the host proteases and exposed its fusion peptide, which resulting in final membrane fusion [9-10]." 1562 2124 W3106676101.pdf 1 9 separator 0.9445363 ¶ 2124 2126 W3106676101.pdf 1 10 text 0.9972503 "The receptor of ACE2 (angiotensin-converting enzyme 2) for SARS CoV and DPP4 (dipeptidyl peptidase 4) for MERS CoV have been reported [11-12]. However, the S-protein is highly glycosylated, as many as 22 potential N- glycosylation sites in the S-protein of SARS CoV could be detected, compared to 23 N-glycosylation sites in the S- protein of MERS CoV [13-14]. Therefore, it is worth to figure out the distribution of N-glycosylation sites and glycobiology functions in the S-protein of SARS2 CoV." 2126 2634 W3106676101.pdf 1 11 separator 0.97738254 ¶ 2634 2636 W3106676101.pdf 1 12 text 0.99953514 "In this article, we have compared the evolutionary relationship and distribution of N-glycosylation sites in different CoVs. For the distribution and possible functions in the N-glycosylation sites, a homologous modeling method had been adopted. Further docking analysis have provided a visual method for the possible glycan binding domains. These works should contribute to explan the highly contagious of new SARS2 CoV and provide new strategy on SARS2 CoV prevention." 2636 3119 W3106676101.pdf 1 13 separator 0.9970297 ¶ 3119 3121 W3106676101.pdf 1 14 title 0.99086446 1 Methods 3121 3131 W3106676101.pdf 1 15 separator 0.98900616 ¶ 3131 3133 W3106676101.pdf 1 16 title 0.9922129 1.1 Phylogenetic analysis for S protein and N-glycosylation sites 3133 3199 W3106676101.pdf 1 17 separator 0.9950545 ¶ 3199 3201 W3106676101.pdf 1 18 text 0.99964714 "For the purpose of the evolution of S-protiens and N-glycosylation sites in CoVs, a dataset of S-protein sequences from representative 1169 CoVs was retrieved from the National Center for Biotechnology Information (NCBI) VIRUS database (https://www.ncbi.nlm.nih.gov/labs/virus, accessed in April.15th 2020), containing approximately 438 human reports in 1023 sequences[15]. An alignment of whole sequences was performed by ClustalW 2.0 in MEGA 7.0 (File S1)[16]. A webtool named “NetNGlyc 1.0 Server” was used for the N-glycosylation sites predicting[17]. To investigate the evolutionary relationship of N-glycosylation sites in different subgenus, a smaller dataset was used for further analysis with 49 representative sequences, including the HKU1, OC43, NL63, 229E, SARS, MERS as well as SARS2 CoVs. Unrooted phylogenetic tree was constructed using the Neighbor- Joining method and the Poisson correction model. The internal branching probabilities were determined by bootstrap analysis with 1,000 replicates similar to previous description[18]." 3201 4276 W3106676101.pdf 1 0 paratext 0.97687006 Page 5/11 0 9 W4379619123.pdf 4 1 text 0.98603374 Breast metastasis from FTC is extremely rare and imageological examination is always not su 9 100 W4379619123.pdf 4 0 paratext 0.9892688 Rev Bras Enferm [Internet]. 2018;71(supl1):568-76. 570570 0 58 W2791763633.pdf 2 1 separator 0.9794113 ¶ 58 60 W2791763633.pdf 2 2 title 0.80513054 Epidemiological overview of HIV/AIDS in pregnant women from a state of northeastern Brazil Silva CM, Alves RS, Santos TS, Bragagnollo 60 194 W2791763633.pdf 2 3 paratext 0.46915248 GR 194 197 W2791763633.pdf 2 4 title 0.552355 , Tavares CM, 197 210 W2791763633.pdf 2 5 paratext 0.44437203 Santos 210 217 W2791763633.pdf 2 6 title 0.86339206 AAP.Study protocol 217 236 W2791763633.pdf 2 7 separator 0.99098766 ¶ 236 238 W2791763633.pdf 2 8 text 0.9957829 "Data collection was carried out from May 2016 to April 2017 through the Epidemiological Surveillance database, available in the Secretariat of Health of São Paulo (SES), as well as the System for Notifiable Diseases (SINAN) and Infor - mation System on live births (SINASC), provided by the De - partment of Informatics of the Brazilian Unified Health System – DATASUS regarding the total number of cases of pregnant women with HIV/AIDS notified in Alagoas." 238 711 W2791763633.pdf 2 9 separator 0.8704858 ¶ 712 714 W2791763633.pdf 2 10 text 0.996155 "The data collected were organized from epidemiological variables divided into three typologies: sociodemographic (age, race/color, and education), health (year of diagnosis and birth year) and access to health services (prenatal and sero - logical evidence period)." 714 993 W2791763633.pdf 2 11 separator 0.9966339 ¶ 994 996 W2791763633.pdf 2 12 title 0.9869789 Results analysis and statistics 996 1028 W2791763633.pdf 2 13 separator 0.99128366 ¶ 1028 1030 W2791763633.pdf 2 14 text 0.99872065 "The numbers were exported to the software Tabwin 2.7, being tabulated and compiled into the software Microsoft Excel 2016 for Windows®. The incidence coefficients were obtained from the number of HIV cases detected in pregnant women living in Alagoas in the given period, divided by the total number of live births residing in the same place and year of notification, with demographic information available through demographic censuses." 1030 1482 W2791763633.pdf 2 15 separator 0.7214032 ¶ 1483 1485 W2791763633.pdf 2 16 text 0.99867016 "Subsequently, data were submitted to descriptive analysis, through the measures of dispersion parameter, using the arith - metic mean and standard deviation (X ± S), seeking to arrange the variability of the data. Following the measurement, the data were presented in graphs and table through absolute and relative frequency, as well as detection coefficient (or rate)." 1485 1871 W2791763633.pdf 2 17 title 0.98400587 RESULTS 1871 1878 W2791763633.pdf 2 18 separator 0.9954342 ¶ 1879 1881 W2791763633.pdf 2 19 text 0.99937934 "Considering the variables studied, in the period between 2007 and 2015, 773 cases of pregnant women with HIV/AIDS were identified in the state of Alagoas. Table 1 shows that 31.2% of the pregnant women declared from 5 to 8 years of schooling (X=30.5 and S=8.6), while 7.4% of them did not attend school (X=3.2 and S=7.7) and 1.9% presented 12 years or more of schooling." 1881 2261 W2791763633.pdf 2 20 separator 0.86636597 ¶ 2261 2263 W2791763633.pdf 2 21 text 0.9994704 "Concerning these women’s age group, the group from 20 to 34 years showed the highest percentage of cases, with 70.9% (X=71.8 and S=6.4), followed by the age group from 15 to 19 years, with percentage of 18.6% (X=18.3 and S=5.8). We also highlight the cases of pregnant women with HIV/AIDS in the age group below 15 years, which recorded 12 cases in the study period, totaling a percentage of 1.5% (X=1.4 and S=0.9)." 2263 2688 W2791763633.pdf 2 22 separator 0.9175786 ¶ 2688 2690 W2791763633.pdf 2 23 text 0.9993085 "Regarding the variable race/color, we can infer that 72.1% of pregnant women have declared themselves as being mixed-race, which is the phenotype responsible for the highest number of cases during the period (X=72.1 and S=5.6), followed by the white color, with 11.8% (X=12.2 and S=3.5). On the oth - er hand, we observed an increase in cases of race/black color, which are reaching the second position in some of the years studied, showing percentage of 10.6% (X=10.1 and S=5.6)." 2690 3187 W2791763633.pdf 2 24 separator 0.962181 ¶ 3187 3189 W2791763633.pdf 2 25 text 0.9972237 "Regarding the progress of the cases, the detection rate of pregnant women with HIV/AIDS in the state of Alagoas has been showing a tendency of increase in recent years (X=1.7 S=0.5). Figure 1 shows a rate of 1.0 case/1,000 live births in 2007, which passed to 2.5 in 2015, being the year with the largest rate in the study period after increase of 150%." 3189 3555 W2791763633.pdf 2 26 separator 0.996837 ¶ 3555 3557 W2791763633.pdf 2 27 title 0.979158 Table 1 – Distribution of HIV/AIDS cases in pregnant women according to sociodemographic data, Alagoas, Brazil, 2007 to 2015 3557 3682 W2791763633.pdf 2 28 separator 0.99191856 ¶ 3682 3684 W2791763633.pdf 2 29 table 0.99556607 "Variables2007 n(%)2008 n(%)2009 n(%)2010 n(%)2011 n(%)2012 n(%)2013 n(%)2014 n(%)2015 n(%)X *± S** n Schooling Ign***/blank 8(16) 10(13.7) 8(11.4) 21(27.6) 22(26.5) 8(11) 20(19.2) 21(18.1) 27(21.1) 18.3 ± 6.0 None 5(10) 8(10.9) 9(12.9) 5(6.6) 6(7.2) 2(2.7) 9(8.6) 6(5.2) 7(5.5) 7.7 ± 3.2 From 1 to 4 13(26) 34(46.6) 18(23.7) 18(23.7) 21(25.3) 19(26) 20(19.2) 26(22.4) 22(17.2) 25.8 ± 8.4 From 5 to 8 14(28) 9(12.3) 21(30) 25(32.9) 22(26.5) 31(42.5) 34(32.7) 34(29.3) 51(39.8) 30.5 ± 8.6 From 9 to 11 9(18) 8(11) 10(14.3) 7(9.2) 10(12.1) 12(16.4) 19(18.3) 28(24.1) 21(16.4) 15.5 ± 4.5 From 12 and more 1(2) 4(5.5) 4(5.7) 0(0.0) 2(2.4) 1(1.4) 2(2) 1(0.9) 0(0.0) 2.2 ± 2.1 Age group >15 years 0(0) 1(1.4) 0(0) 1(1.3) 1(1.2) 1(1.4) 3(2.9) 2(1.7) 3(3.2) 1.4 ± 0.9 15 to 19 years 5(10) 12(16.4) 16(22.9) 16(21.1) 13(15.7) 18(24.6) 11(10.6) 20(17.2) 33(25.8) 18.3 ± 5.8 20 to 34 years 42(84) 55(75.3) 49(70) 50(65.8) 62(74.7) 50(68.5) 80(76.9) 78(67.3) 82(64.1) 71.8 ± 6.4 35 to 49 years 3(6) 5(6.9)) 5(7.1) 9(11.8) 7(8.4) 4(5.5) 10(9.6) 16(13.8) 10(7.8) 8.5 ± 2.7 Race/Color Ign***/blank 4(8) 3(4.1) 3(4.3) 4(5.3) 4(4.8) 3(4.1) 3(2.9) 6(5.2) 6(4.7) 4.8 ± 1.4 White 6(12) 7(9.6) 11(15.7) 9(11.8) 14(16.9) 11(15.1) 14(13.5) 7((6) 12(9.4) 12.2 ± 3.5 Black 5(10) 5(6.8) 2(2.9) 4(5.3) 7(8.4) 14(19.2) 8(7.7) 21(18.1) 16(12.5) 10.1 ±5.6 Yellow 0(0.0) 0(0.0) 0(0.0) 1(1.3) 1(1.2) 0(0.0) 0(0) 2(1.7) 1(0.8) 0.6 ± 0.7 Mixed-race 35(70) 58(79.5) 54(77.1) 58(76.3) 57(68.7) 45(61.6) 78(75) 79(68.1) 93(72.6) 72.1 ± 5.6 Indigenous 0(0) 0(0) 0(0) 0(0) 0(0) 0(0) 1(0.9) 1(0.9) 0(0) 0.2 ± 0.4" 3684 5326 W2791763633.pdf 2 30 separator 0.79822755 ¶ 5326 5328 W2791763633.pdf 2 31 bibliography 0.59632075 Source: SINAN/SINASC/SES/AL, 2017. 5328 5363 W2791763633.pdf 2 32 separator 0.97833 ¶ 5363 5365 W2791763633.pdf 2 33 table 0.34488264 5365 5366 W2791763633.pdf 2 34 bibliography 0.31139472 Notes: 5366 5372 W2791763633.pdf 2 35 table 0.38862664 * 5372 5374 W2791763633.pdf 2 36 bibliography 0.34085754 Arithmetic 5374 5384 W2791763633.pdf 2 37 table 0.34949675 mean; ** 5384 5393 W2791763633.pdf 2 38 bibliography 0.3585774 Standard 5393 5401 W2791763633.pdf 2 39 table 0.37119597 deviation; *** 5401 5416 W2791763633.pdf 2 40 bibliography 0.3586427 Ignor 5416 5421 W2791763633.pdf 2 41 table 0.35806656 ed. 5421 5424 W2791763633.pdf 2 0 paratext 0.81091285 "¶ ¶ ¶ Knowledge Management & E -Learning , 12(4), 405–418 415 ¶ ¶ ¶ ¶ ¶" 1 145 W3145355484.pdf 11 1 separator 0.8412275 ¶ ¶ 150 162 W3145355484.pdf 11 2 text 0.9964198 "the ones in Canada I have had to contact the hospital in New York (where I had received my surgery) on several occassions for information relevant to my Cana dian healt hcare providers ." 163 358 W3145355484.pdf 11 3 separator 0.9963465 ¶ 359 361 W3145355484.pdf 11 4 title 0.9935498 2.5. Phase 5 - Long -term recovery 361 397 W3145355484.pdf 11 5 separator 0.99525595 ¶ 399 401 W3145355484.pdf 11 6 text 0.9996563 "In this final phase of my journey , the focus of my attention shifted from a curative focus to how to recover from the surgery, chemotherapy and radiation in order t o fully regain my ability to e at and spe ak (corresponding to the months April – June 2018 in Fig . 1)." 401 678 W3145355484.pdf 11 7 separator 0.91096616 ¶ 679 681 W3145355484.pdf 11 8 text 0.99969137 "This involved help fr om a speech therapist and dietician at the Cancer Agency over a several month period from January until June 2018. I wanted to cont inue to be an empowered active p articipant in my own care by staying informed of the latest trends and research on my previou s condition and therefore I continued to research and read relevant articles online from PubMed and other reputable sources. I also explored blogs and postings on YouTube an d Pinterest, posted by patients who had undergone similar treatment and therapy. Th is aided in not only giving me realistic expectations regarding recovery , but also in sharing strategies and tips for the road to r ecovery. Once again, the Interne t became a big part of my patient journey and helped me to become increasingly confident abou t my future and long -term health outcome over the ensuing months ." 681 1581 W3145355484.pdf 11 9 separator 0.9697747 ¶ 1582 1584 W3145355484.pdf 11 10 text 0.9997186 "I am now three years cancer free, which according to the statisti cs indicates I should be cancer free for the long term , now officially having “beat cancer”. Furthermore, I have continued w ith all activities I undertook before becoming ill. Much of what happened and I how I was able to turn around what appeared to be a bleak situation I can attribute to my frie nds and colleagues, a range of health professionals, and the information we gleane d fro m the Internet that was critical to my health and well -being ." 1584 2120 W3145355484.pdf 11 11 separator 0.9973135 ¶ 2121 2123 W3145355484.pdf 11 12 title 0.9935273 2.5.1. Personal use of the WWW 2123 2155 W3145355484.pdf 11 13 separator 0.99477905 ¶ 2157 2159 W3145355484.pdf 11 14 text 0.99973744 "As a result of my experience, I continue to use the WWW extensive ly to keep with advances in treatment of the cancer I had, to read about others’ experiences and to l earn more about how to identify any future symptoms that might indicate a recurrence. I also encour age others (through my t eaching , patient journey researc h and work ) who may be facing some of the same difficult health scenarios to become familiar with the array of information resources available to all of us. The information I continue to search for from the WWW is an invalu able aid in understanding and dis cussing lo ng-term monitoring decisions with my health professionals and I continue to personally sea rch for information relevant to cancer care in general and for new advances. In addition, as a health information science r esearcher I have started several new paths of research to help patients understand the full range of treatment options and present th em with effective information visualizations that can be shared between them and their health providers ." 2159 3251 W3145355484.pdf 11 15 separator 0.9972333 ¶ 3252 3254 W3145355484.pdf 11 16 title 0.9939548 2.5.2. Institutio nal information systems 3254 3297 W3145355484.pdf 11 17 separator 0.99540496 ¶ 3299 3301 W3145355484.pdf 11 18 text 0.9997226 "My health informati on related to this case is now distributed across numerous health information systems (e.g. EMRs i n Canada and the US) and organization s (e.g. my local GP, operating surgeon, local cancer agency etc.). In addition , I have become “curator” of my o wn critica l health information, creating a personal database of all the reports, scans and relevant articles I have collected along my journey. I have compiled all this information personally as spreadsheets and files on my own personal computer, and conti nue to do so." 3301 3865 W3145355484.pdf 11 0 paratext 0.9892465 WWW.PRO.RSU.RU 0 14 W2144363446.pdf 1 1 separator 0.9948113 ¶ 14 16 W2144363446.pdf 1 2 title 0.9485126 28террористической угрозы, в ситуации проявления экстремизма в молодежной 16 90 W2144363446.pdf 1 3 separator 0.58727074 ¶ 91 93 W2144363446.pdf 1 4 title 0.8423931 среде 93 99 W2144363446.pdf 1 5 text 0.9844207 ". Стимулирующая ситуация теста рисуночной фрустрации заключается в схематическом контурном рисунке, который предполагают три совершенно конкретных ситуации." 99 261 W2144363446.pdf 1 6 separator 0.96123755 ¶ 261 263 W2144363446.pdf 1 7 text 0.99523616 "Вовлечение в группировку по средствам угрозы, шантажа, демонстрации 1. силы, ультимативных требований. На стимульных карточках изображены три ситуации: «Кто не с нами – тот против нас», «Если ты не с нами, то пострадают твои близкие», «Если ты не с нами – тебе несдобровать»." 263 548 W2144363446.pdf 1 8 separator 0.81890595 ¶ 548 550 W2144363446.pdf 1 9 text 0.99713784 "Экстремистское проявление в молодежной среде. Предполагается, что для 2. каждого тестирующегося это будет своя наиболее значимая ситуация: прояв - ление экстремизма по отношению к представителю другой национальности, представителю другой социальной группы, представителям другого статуса, конфессиональной принадлежности. На стимульных карточках изображены три ситуации: «Футбол», «Сосед по парте», «Дедовщина»." 550 976 W2144363446.pdf 1 10 separator 0.97417283 ¶ 976 978 W2144363446.pdf 1 11 text 0.9864148 "Ситуация угрозы террористического акта. Три стимульных карточки: 3. «Заложники», «Угроза взрыва», «Отношение к теракту»." 978 1102 W2144363446.pdf 1 12 separator 0.97482973 ¶ 1102 1104 W2144363446.pdf 1 13 text 0.99832296 "Всего представлено 9 стимульных ситуаций, на которых изображены лица, находящиеся во фрустрационной ситуации. Все ситуации, представленные в тесте, можно отнести к ситуации «препятствия», так как в них какой-нибудь персонаж или группа людей обескураживает, сбивает с толку угрозой или словом." 1104 1408 W2144363446.pdf 1 14 separator 0.992948 ¶ 1409 1411 W2144363446.pdf 1 15 text 0.9976486 "Порядок обработки результатов тестирования аналогичен анализу ответов во фрустрационно-рисуночном тесте С. Розенцвейга [1]. Анализируются направле - ния реакций: экстрапунитивные – реакция направлена на живое или неживое окружение в форме подчеркивания степени фрустрирующей ситуации, в форме осуждения внешней причины фрустрации, или вменяется в обязанность друго - му лицу разрешить данную ситуацию, интрапунитивные – реакция направлена субъектом на самого себя; испытуемый принимает фрустрирующую ситуацию как благоприятную для себя, принимает вину на себя или берет на себя ответ - ственность за исправление данной ситуации, импунитивные – фрустрирующая ситуация рассматривается субъектом как малозначащая, как отсутствие чьей- либо вины, или нечто такое, что может быть исправлено само собой, стоит только подождать и подумать [1]." 1411 2278 W2144363446.pdf 1 16 separator 0.9486111 ¶ 2278 2280 W2144363446.pdf 1 17 text 0.993 "Первичные результаты по данной методике были получены в ходе моло - дежного антитеррористического фестиваля, прошедшего в г. Ростове-на-Дону в 2010 году." 2280 2439 W2144363446.pdf 1 18 separator 0.97905576 ¶ 2439 2441 W2144363446.pdf 1 19 text 0.9989193 "Типичной реакцией студентов на ситуацию вовлечения в экстремистскую группировку была защитная реакция, направленная на живое или неживое окружение в форме отстаивания собственных позиций, с элементами осуждения внешней причины фрустрации, а также реакция принятия на себя ответственности за создавшуюся ситуацию." 2441 2767 W2144363446.pdf 1 20 separator 0.97219765 ¶ 2767 2769 W2144363446.pdf 1 21 text 0.9991198 "В ситуации угрозы террористического акта обнаруживаются усиления ре - акций на удовлетворение потребности в обеих группах: требуется, ожидается," 2769 2917 W2144363446.pdf 1 0 text 0.99814224 "normalized, correcting for the interday machine tuning effect by dividing each metabolite’s value by the median per run for the day. Then, the data were further standardized before the analyses. For the 36 MZ twins, the mean difference of metabolite levels within twin pair (affected–unaffected twin) was calculated. One- sample non-parametric test (Wilcoxon signed-rank test) was calculated to assesswhether the mean difference for each metabolite was significantly different from 0." 0 491 W2032662504.pdf 5 1 separator 0.96939415 ¶ 491 493 W2032662504.pdf 5 2 text 0.9984869 "50 metabolites nominally associated with DNA methylation ( Po0.05) were then tested in the replication sample set. The meta-analysis of discovery ( n1⁄436 IDs) and replication ( n1⁄424 IDs) samples provided the overall pvalue for the association between metabolite levels and DNA methylation profiles." 493 796 W2032662504.pdf 5 3 separator 0.9953896 ¶ 796 798 W2032662504.pdf 5 4 text 0.997497 "Gene expression profiles.Gene expression results in adipose, skin and lymphoblastoid cell line tissue was extracted for 590 subjects from MuTHERstudy19. Gene expression levels were measured using the Illumina expression array HumanHT-12 version 3. Each sample had three technical replicates and log2- transformed expression signals, which were quantile normalized, first across three replicates of each individual, and then secondly by quantile normalization across all individuals. We used the transformed normalized residuals of the log-transformedgene expression array signal in this analysis." 798 1403 W2032662504.pdf 5 5 separator 0.9953938 ¶ 1403 1405 W2032662504.pdf 5 6 text 0.996826 "Genotype data.Genotype data for the individuals in this study were obtained on a combination of Illumina platforms (HumanHap300, HumanHap610Q, 1M-Duo and 1.2MDuo 1M custom arrays). The genotypes were called with the Illuminuscalling algorithm (maximum posterior probability of 0.95). Imputation was per- formed using the IMPUTE software package (v2) using two reference panels: P0 (HapMap2, rel 22, combined CEU) and P1 (610K þ, including the combined HumanHap610K and 1M array). After imputation, SNPs were filtered for MAF of 45% and IMPUTE info value of 40.8 (ref. 19)." 1405 1989 W2032662504.pdf 5 7 separator 0.99628377 ¶ 1989 1991 W2032662504.pdf 5 8 text 0.9917067 "Methylation QTL identification.Cismethylation QTL at DMRs was analysed using SNPs within 50 kb of the region. For each DMR, the methylation values werenormalized to N (0, 1), and we then fitted a linear model, regressing the methy- lation levels on fixed-effect terms including genotype, age and gender. Multiple testing was corrected for by the Bonferroni correction. We further tested whether methylation acts as a mediator between genotype and phenotype. This was assessed using the causal inference test8,31. The genetic effect on DMRs was calculated using a linear mixed effects model, we regressed the RPM value for each DMR on fixed- effect terms, which included disease status, BMI, age, sex and random-effect terms denoting family structure." 1991 2754 W2032662504.pdf 5 9 separator 0.99422044 ¶ 2754 2756 W2032662504.pdf 5 10 text 0.9987826 "Trans methylation QTLs at DMRs were analysed in the replication sample using 2.1M SNPs in the genome ( P1⁄42.4/C210/C08,F D R 1⁄45%). For each DMR, the methylation values were normalized to N (0, 1), and we performed association analyses by using linear regression implemented in PLINK47, assuming additive genetic effects, with adjustment for age and sex." 2756 3117 W2032662504.pdf 5 11 separator 0.99604714 ¶ 3117 3119 W2032662504.pdf 5 12 text 0.989003 "Pathway analysis .Pathway analysis was performed using two methods: Cytoscape v2.83 (ref. 48) and GREAT49. We used DMR or giDMR annotated gene list for Cytoscape analysis with FDR o0.001. For GREAT, we analysed separately the T2D-DMR and giDMR regions and applied the regional-based binomial approachwith the maximum distal extension reduced to from 1 Mb to 150 kb." 3119 3491 W2032662504.pdf 5 13 separator 0.9907248 ¶ 3491 3493 W2032662504.pdf 5 14 title 0.77027935 References 3493 3504 W2032662504.pdf 5 15 separator 0.9859473 ¶ 3504 3506 W2032662504.pdf 5 16 bibliography 0.9979923 "1. Morris, A. P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981–990 (2012)." 3506 3687 W2032662504.pdf 5 17 separator 0.72728574 ¶ 3687 3689 W2032662504.pdf 5 18 bibliography 0.99797195 "2. Robertson, K. D. DNA methylation and human disease. Nat. Rev. Genet. 6, 597–610 (2005)." 3689 3782 W2032662504.pdf 5 19 separator 0.6805005 ¶ 3782 3784 W2032662504.pdf 5 20 bibliography 0.99806476 "3. Rakyan, V. K., Down, T. A., Balding, D. J. & Beck, S. 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Diabetes 62,4270–4276 (2013)." 6644 6800 W2032662504.pdf 5 55 separator 0.900455 ¶ 6800 6802 W2032662504.pdf 5 56 bibliography 0.9978844 "22. Adrian, T. E. et al. Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers.Diabetologia 55,2343–2347 (2012)." 6802 7003 W2032662504.pdf 5 57 separator 0.90569067 ¶ 7003 7005 W2032662504.pdf 5 58 bibliography 0.99814385 "23. Falls, J. G., Pulford, D. J., Wylie, A. A. & Jirtle, R. L. Genomic imprinting: implications for human disease. Am. J. Pathol. 154, 635–647 (1999)." 7005 7158 W2032662504.pdf 5 59 separator 0.85058343 ¶ 7158 7160 W2032662504.pdf 5 60 bibliography 0.9979506 "24. Kong, A. et al. Parental origin of sequence variants associated with complex diseases. Nature 462, 868–874 (2009)." 7160 7281 W2032662504.pdf 5 61 separator 0.8518802 ¶ 7281 7283 W2032662504.pdf 5 62 bibliography 0.99801403 "25. Lawson, H. A., Cheverud, J. M. & Wolf, J. B. Genomic imprinting and parent- of-origin effects on complex traits. Nat. Rev. Genet. 14,609–617 (2013)." 7283 7438 W2032662504.pdf 5 63 separator 0.8698709 ¶ 7438 7440 W2032662504.pdf 5 64 bibliography 0.99782383 "26. Mackay, D. J. et al. Hypomethylation of multiple imprinted loci in individuals with transient neonatal diabetes is associated with mutations in ZFP57. Nat. Genet. 40,949–951 (2008)." 7440 7630 W2032662504.pdf 5 65 separator 0.9272448 ¶ 7630 7632 W2032662504.pdf 5 66 bibliography 0.9979464 "27. Cheverud, J. M. et al. Genomic imprinting effects on adult body composition in mice. Proc. Natl Acad. Sci. USA 105, 4253–4258 (2008)." 7632 7772 W2032662504.pdf 5 67 separator 0.89403176 ¶ 7772 7774 W2032662504.pdf 5 68 bibliography 0.9980134 "28. Gluckman, P. D., Hanson, M. A., Cooper, C. & Thornburg, K. L. Effect of in utero and early-life conditions on adult health and disease. N. Engl. J. Med. 359, 61–73 (2008)." 7774 7954 W2032662504.pdf 5 69 separator 0.9280342 ¶ 7954 7956 W2032662504.pdf 5 70 bibliography 0.9979922 "29. Ohno, H., Shinoda, K., Spiegelman, B. M. & Kajimura, S. PPARgamma agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 15,395–404 (2012)." 7956 8150 W2032662504.pdf 5 71 separator 0.86938965 ¶ 8150 8152 W2032662504.pdf 5 72 bibliography 0.99761385 "30. Kajimura, S. et al. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 22,1397–1409 (2008)." 8152 8311 W2032662504.pdf 5 73 separator 0.9451088 ¶ 8311 8313 W2032662504.pdf 5 74 bibliography 0.99800587 "31. Millstein, J., Zhang, B., Zhu, J. & Schadt, E. E. Disentangling molecular relationships with a causal inference test. BMC Genet. 10,23 (2009)." 8313 8462 W2032662504.pdf 5 75 separator 0.89301085 ¶ 8462 8464 W2032662504.pdf 5 76 bibliography 0.99765503 "32. Nambu, H. et al. Characterization of metabolic phenotypes of mice lacking GPR61, an orphan G-protein coupled receptor. Life Sci. 89,765–772 (2011)." 8464 8620 W2032662504.pdf 5 77 separator 0.951259 ¶ 8620 8622 W2032662504.pdf 5 78 bibliography 0.9978972 "33. Chin, J. E., Dickens, M., Tavare, J. M. & Roth, R. A. Overexpression of protein kinase C isoenzymes alpha, beta I, gamma, and epsilon in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J. Biol. Chem. 268, 6338–6347 (1993)." 8622 8901 W2032662504.pdf 5 79 separator 0.93683803 ¶ 8901 8903 W2032662504.pdf 5 80 bibliography 0.99797213 "34. Koya, D. & King, G. L. Protein kinase C activation and the development of diabetic complications. Diabetes 47,859–866 (1998)." 8903 9035 W2032662504.pdf 5 81 separator 0.85635746 ¶ 9035 9037 W2032662504.pdf 5 82 bibliography 0.9976833 "35. Nishimura, S. et al. CD8þeffector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15,914–920 (2009)." 9037 9196 W2032662504.pdf 5 83 separator 0.9207896 ¶ 9196 9198 W2032662504.pdf 5 84 bibliography 0.9979865 "36. Gregor, M. F. & Hotamisligil, G. S. Inflammatory mechanisms in obesity. Annu. Rev. Immunol. 29,415–445 (2011)." 9198 9314 W2032662504.pdf 5 85 separator 0.7838439 ¶ 9314 9316 W2032662504.pdf 5 86 bibliography 0.9979158 "37. Vandanmagsar, B. et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat. Med. 17,179–188 (2011)." 9316 9460 W2032662504.pdf 5 87 separator 0.90656865 ¶ 9460 9462 W2032662504.pdf 5 88 bibliography 0.99769694 "38. Gkrania-Klotsas, E. et al. Differential white blood cell count and type 2 diabetes: systematic review and meta-analysis of cross-sectional and prospective studies. PLoS One 5,e13405 (2010)." 9462 9660 W2032662504.pdf 5 89 separator 0.9084454 ¶ 9660 9662 W2032662504.pdf 5 90 bibliography 0.9978761 "39. Adalsteinsson, B. T. et al. Heterogeneity in white blood cells has potential to confound DNA methylation measurements. PLoS ONE 7,e46705 (2012)." 9662 9813 W2032662504.pdf 5 91 separator 0.9022341 ¶ 9813 9815 W2032662504.pdf 5 92 bibliography 0.9978853 "40. Moayyeri, A., Hammond, C. J., Hart, D. J. & Spector, T. D. The UK Adult Twin Registry (TwinsUK Resource). Twin Res. Hum. Genet. 16,144–149 (2013)." 9815 9970 W2032662504.pdf 5 93 separator 0.9459039 ¶ 9970 9972 W2032662504.pdf 5 94 bibliography 0.9927297 "41. Andrews, S. A quality control tool for high throughput sequence data. Available at http://wwwbioinformaticsbabrahamacuk/projects/fastqc/ (2010).ARTICLE" 9972 10130 W2032662504.pdf 5 95 paratext 0.96176493 "NATURE COMMUNICATIONS | DOI: 10.1038/ncomms6719 6 NATURE COMMUNICATIONS | 5:5719 | DOI: 10.1038/ncomms6719 | www.nature.com/naturecommunications &2014 Macmillan Publishers Limited. All rights reserved." 10130 10336 W2032662504.pdf 5 0 text 0.9991494 "ESIN in femur and forearm fractures led us to use this technique to treat tibial shaft fractures [ 7–9]. In our depart- ment, since 2000 every displaced diaphyseal tibial fracture in patents over the age of 6 years was therefore treated by ESIN, apart from Gustilo 2 and 3 open fractures that were treated by external fixation [ 20]. It is generally recognized that the minimal age for ESIN is 6 years old, apart from polytrauma patients for whom there is no age limit [ 7]. The mean age of our patients was 11 years and 8 months. We had only one patient under the age of six who sustained poly- trauma with a floating knee. Moreover, the fracture types in our study population were similar to those described in the literature [ 10,14,16,21]." 0 765 W1964455581.pdf 4 1 separator 0.8474132 ¶ 765 767 W1964455581.pdf 4 2 text 0.9981363 "Our study on 86 young patients confirms the efficiency of this technique in the immediate treatment of tibial shaft fractures. The operation duration was short in cases devoid" 767 945 W1964455581.pdf 4 3 title 0.98833025 Table 5 Comparison of displacements between postoperative days 15, 30 and 45 radiographies 945 1035 W1964455581.pdf 4 4 separator 0.95684147 ¶ 1035 1037 W1964455581.pdf 4 5 table 0.99623764 "Displacement type Day 15 radiographies Day 30 radiographies Day 45 radiographies N Mean displacement (range) N Mean displacement (range) N Mean displacement (range) Isolated varus ( /C176) 4 3.9 (1–7) 6 3.8 (1–8) 8 4.1 (2–7) Varus with procurvatum ( /C176)3 2 1 Varus with recurvatum ( /C176)5 8 7 Isolated valgus ( /C176) 6 3.8 (1–15) 6 3.2 (1–10) 4 4 (1–10) Valgus with procurvatum ( /C176)9 8 5 Valgus with recurvatum ( /C176)6 2 4 Isolated procurvatum ( /C176) 4 4.3 (2–13) 2 3.4 (1–10) 4 3.7 (2–10) Isolated recurvatum ( /C176) 9 4.5 (1–10) 9 4.6 (2–15) 8 5 (2–13) Lengthening (mm) 3 3.7 (3–4) 2 2.5 (2–3) 2 2.5 (2–3) Shortening (mm) 11 3.1 (1–7) 8 5.2 (3–11) 9 4.7 (2–11) Medial translation (mm) 6 4.2 (1–5) 6 4.2 (2–6) Lateral translation (mm) 9 2.7 (1–5) 9 2.7 (1–5)" 1037 1838 W1964455581.pdf 4 6 separator 0.9853952 ¶ 1838 1840 W1964455581.pdf 4 7 title 0.93896943 Table 6 Comparison of displacements between 6-month, 1- and 2-year radiographies 1840 1921 W1964455581.pdf 4 8 separator 0.9341048 ¶ 1921 1923 W1964455581.pdf 4 9 table 0.99606943 "Displacement 6-month radiographies 1-year radiographies 2-year radiographies N Mean displacement (range) N Mean displacement (range) N Mean displacement (range) Isolated varus ( /C176) 6 5.1 (1–6) 1 1.5 (1–2) 2 1.5 (1–2) Varus with procurvatum ( /C176)3 1 Varus with recurvatum ( /C176)5 0 Isolated valgus ( /C176) 5 4.3 (1–9) 3 3.7 (1–5) 2 3 (1–5) Valgus with procurvatum ( /C176)2 0 Valgus with recurvatum ( /C176)6 0 Isolated procurvatum ( /C176) 5 3.8 (1–5) 1 1 Isolated recurvatum ( /C176) 13 6.2 (3–10) 0 Lengthening (mm) 13 5.2 (1–10) 5 5.6 (2–5) 5 5.4 (2–8) Shortening (mm) 15 6.2 (2–13) 10 4.3 (1–6) 10 4 (1–5) FTA: valgus ( /C176) 12 2.7 (1–5) 4 3.5 (2–5) 3 3 (2–4) FTA: varus ( /C176) 16 3.9 (1–8) 10 4.7 (4–6) 8 4.3 (4–5) FTA femoro-tibial axis" 1923 2708 W1964455581.pdf 4 10 separator 0.8366713 ¶ 2708 2710 W1964455581.pdf 4 11 caption 0.75310147 "Progression of the number of patients with displacements between D0 and M24." 2710 2790 W1964455581.pdf 4 12 separator 0.87358797 ¶ 2790 2792 W1964455581.pdf 4 13 caption 0.9887817 "Fig. 2 Progression of the number of patients with fracture displace- ment ( varus ,valgus ,procurvatum and recurvatum angulation) between day 0 and 2 years" 2792 2952 W1964455581.pdf 4 14 paratext 0.803672 J Child Orthop (2011) 5:297–304 301 2952 2987 W1964455581.pdf 4 15 separator 0.8006608 ¶ 2987 2989 W1964455581.pdf 4 16 paratext 0.963619 123 2989 2993 W1964455581.pdf 4 0 paratext 0.9239397 "333 Cur Op Gyn Obs, 2(1): 318-345 (2019)" 0 43 W2977729887.pdf 15 1 title 0.8545221 "ET, EE and EAOC; ET cell line (CRL-7566) and EAOC cell line (CRL-11731)" 44 123 W2977729887.pdf 15 2 text 0.986058 "Higher miR-191 in ET, highest in EAOC, possi - bly associated with the regulation of cell pro - liferation and invasion.Notable that miR-191 may mediate tumorigenic activity of estrogen in ER positive target cells." 123 347 W2977729887.pdf 15 3 bibliography 0.8738098 "Dong et al. 2015 [203]; Tian et al. 2015 [204]" 347 397 W2977729887.pdf 15 4 separator 0.94535214 ¶ 397 399 W2977729887.pdf 15 5 text 0.8434773 "ET and OC, paired; United StatesDifferentially regulated miRs including down-regulated miR-1, miR-133a, miR-145 and up-regulated miR-200a, miR-200c, miR- 141 in OC as compared to ET were associ - ated with reduced PTEN expression with no change in NF-kB in OC as compared to endometriosis." 399 709 W2977729887.pdf 15 6 table 0.3671505 W 709 710 W2977729887.pdf 15 7 bibliography 0.432717 u et al 710 717 W2977729887.pdf 15 8 table 0.35499802 . 717 718 W2977729887.pdf 15 9 bibliography 0.38641742 2015 718 723 W2977729887.pdf 15 10 table 0.3220601 [20 723 727 W2977729887.pdf 15 11 text 0.46505225 5] 727 729 W2977729887.pdf 15 12 separator 0.9878175 ¶ 729 731 W2977729887.pdf 15 13 title 0.81373817 ET, EE and Endometrioid 731 755 W2977729887.pdf 15 14 separator 0.5251939 ¶ 756 758 W2977729887.pdf 15 15 text 0.95037293 "OC; Romanian population4 miRs over-expressed in endometriosis, 15 miRs differentially expressed in OC. miR-291- a-3p, miR-325-5p, and miR-492 up-regulated in ET and OC compared with EE; miR-200 family overexpressed in OC compared to ET playing a role in EMT. Let miR family having a role in inhibiting activity on oncogenes (KRAS, HRAS, c-MYC and HMG-2) was down-regulat - ed in OC compared to ET.Bra" 758 1185 W2977729887.pdf 15 16 bibliography 0.5582163 icu et al 1185 1194 W2977729887.pdf 15 17 text 0.4125701 . 2017 [206] 1194 1206 W2977729887.pdf 15 18 separator 0.99003124 ¶ 1206 1208 W2977729887.pdf 15 19 text 0.57177603 Bcl-2: B-cell Lymphoma 2; CE: Control (disease-free) Endometrium; CTNNTB1: Catenin Beta 1; CXCR 1208 1304 W2977729887.pdf 15 20 table 0.44539317 4 1304 1305 W2977729887.pdf 15 21 text 0.62342936 ": C-X-C Chemokine Receptor type 4; EAOC: Endometriosis-Associated Ovarian Cancer; EE: Eutopic endometrium from proven Endometriosis; EEC: Endometrial Endometrioid Cancer; EGFR: Epidermal Growth Factor Receptor; EMT: Epithelial–Mesenchymal Transition; ET: Ectopic Tissue; FOXO1: Forkhead box O1; HE: Hyperplastic Endometrium; HMG-2: High Mobility Group box 2; HRAS: Harvey Rat Sarcoma viral oncogene homolog; GTPase: Guanosine Triphosphatase; KRAS: KRAS proto-" 1305 1779 W2977729887.pdf 15 22 table 0.45745063 on 1779 1781 W2977729887.pdf 15 23 text 0.49249625 cogene; 1781 1789 W2977729887.pdf 15 24 table 0.45450988 lnc 1789 1792 W2977729887.pdf 15 25 text 0.5859652 "RNA: Long non-coding RNA; Let miRNA: Lethal microRNA; MALAT1: Metastasis Associated Lung Adenocarcinoma Transcript 1; MYC: MYC proto-oncogene bHLH, transcription factor; NF-kB: Nuclear Factor Kappa-light-chain-enhancer of activated B cells; OC: Ovarian Cancer; PTEN: Phosphatase and Tensin homolog; STAT3: Signal Transducer and Activator of Transcription 3; TP53: Tumor Protein p53; uPA: uroki - nase-type Plasminogen Activator; VEGF: Vascular Endothelial Growth Factor." 1792 2273 W2977729887.pdf 15 26 separator 0.9964962 ¶ 2273 2275 W2977729887.pdf 15 27 title 0.97814834 Table 4: Common microRNAs in endometriosis and endometriosis-associated ovarian cancers. 2275 2365 W2977729887.pdf 15 28 separator 0.99037004 ¶ 2366 2368 W2977729887.pdf 15 29 table 0.7248097 Between endometriosis and clear cell ovarian cancers 2368 2421 W2977729887.pdf 15 30 separator 0.7230787 ¶ 2422 2424 W2977729887.pdf 15 31 table 0.99204624 "· Upregulated: miR-125b, miR-143, miR-145, miR-145-5p, miR-191, miR-193a-5p, miR-194, miR-195, miR-223, miR-299-5p, miR-362-5p, miR-365, miR-451, miR-509-3-5p, miR-574-3p, miR-574-5p, miR-628-3p. · Down-regulated: let-7a, let-7c, miR-106a, miR-106b, miR-126, miR-141, miR-148a, miR-17-5p, miR-182, miR-183, miR-196b, miR-200c, miR-20a, miR-34c-5p, miR-449b, miR-92a, miR-93." 2424 2824 W2977729887.pdf 15 32 separator 0.9065032 ¶ 2824 2826 W2977729887.pdf 15 33 table 0.95867735 Between endometriosis and endometrioid ovarian cancers 2826 2881 W2977729887.pdf 15 34 separator 0.6758538 2882 2883 W2977729887.pdf 15 35 table 0.98302525 "¶ · Upregulated: miR-16-5p, miR-205, miR-30e-5p, miR-325, miR-492, miR-637. · Down-regulated: let-7f, miR-126. Between clear cell and endometrioid ovarian cancers · Upregulated: miR-200a, miR-200c, miR-21, miR-575. · Down-regulated : let-7d, miR-1, miR-100, miR-101, miR-105, miR-125a, miR-125b-1, miR-126, miR- 133a, miR-137, miR-140, miR-143, miR-144, miR-146b-5p, miR-147, miR-199a, miR-199b, miR-222, miR-224, miR-29b, miR-29c, miR-29c*, miR-302a, miR-302b, miR-302c, miR-34b*, miR-9, miR-9*, miR-99a." 2883 3432 W2977729887.pdf 15 36 separator 0.9867842 ¶ 3432 3434 W2977729887.pdf 15 37 bibliography 0.70338076 Based on Wendel et al. [156]. *miRNA resulting from the other 3434 3496 W2977729887.pdf 15 38 text 0.34708017 side 3496 3501 W2977729887.pdf 15 39 bibliography 0.53026825 of the hairpin, usually assumed to be non 3501 3543 W2977729887.pdf 15 40 text 0.3539077 - 3543 3544 W2977729887.pdf 15 41 bibliography 0.4267927 active. 3544 3551 W2977729887.pdf 15 0 paratext 0.99042654 covid-collective.net/clear Page 3 0 33 W4224209747.pdf 2 1 separator 0.99512935 ¶ 33 35 W4224209747.pdf 2 2 text 0.99270785 "Workers’ Federation (RTWF) represents collective bargaining agencies whilst the Bangladesh Road Transport Owners’ Association (BRTOA) and the Dhaka Road Transport Owners’ Association (DRTOA) protect the interests of bus companies and owners." 35 289 W4224209747.pdf 2 3 separator 0.99640405 ¶ 289 291 W4224209747.pdf 2 4 title 0.99355054 2 The ready-made garment (RMG) sector 291 329 W4224209747.pdf 2 5 separator 0.98926944 ¶ 329 331 W4224209747.pdf 2 6 text 0.99947417 "The RMG industry is one of the largest and most important sectors for Bangladesh. During the Covid-19 period, the government gave a stimulus package to the garment sector, for the workers, amounting to BDT 50bn (about €500m) to support the industry and mitigate the economic shock caused by the pandemic." 331 654 W4224209747.pdf 2 7 separator 0.9966264 ¶ 654 656 W4224209747.pdf 2 8 title 0.9917877 Existing data gaps and research opportunities 656 702 W4224209747.pdf 2 9 separator 0.9889456 ¶ 702 704 W4224209747.pdf 2 10 text 0.99344814 "The pandemic has exacerbated existing challenges and emphasised the need to focus on issues such as workers’ health and safety, job security, and working conditions. There is little research and discussion on how Covid-19 continues to impact garment workers’ employment security and future. What research exists fails to make important distinctions in how workers are paid. For example, sweater and knit industry workers are paid on a piece-rate basis so they were more impacted by the loss of orders due to the pandemic. There is no concrete data on how many factories were affected by the pandemic, how many closed down permanently, how many jobs have now been lost or gained, and what changes have been made to the rights of workers and freedom of association." 704 1514 W4224209747.pdf 2 11 separator 0.547567 ¶ 1515 1517 W4224209747.pdf 2 12 text 0.99474996 "Studies discuss the economic impact and future of the RMG industry, but rarely consider workers’ rights and livelihoods. Further studies could be conducted to better understand the role of trade unions in workers’ social protection, and to understand what the obstacles are and how they can be overcome." 1517 1838 W4224209747.pdf 2 13 separator 0.9968847 ¶ 1838 1840 W4224209747.pdf 2 14 title 0.99190885 Key stakeholders 1840 1857 W4224209747.pdf 2 15 separator 0.9949902 ¶ 1857 1859 W4224209747.pdf 2 16 text 0.99951047 "The RMG sector, given its economic importance and size, has many key stakeholders. The MoLE, the Department of Labour and Employment (DoLE), and the Department of Inspection for Factories and Establishments (DIFE) are among the most important government stakeholders." 1859 2142 W4224209747.pdf 2 17 separator 0.7148645 ¶ 2143 2145 W4224209747.pdf 2 18 text 0.9950172 "Factory owners, through the Bangladesh Garment Manufacturers and Exporters Association (BGMEA) and the Bangladesh Knitwear Manufacturers and Exporters Association (BKMEA), tend to have a high influence in policymaking. Trade unions in this sector are generally politicised, divided, and less capable of protecting workers’ rights. Moreover, factory management has taken initiatives to discourage and obstruct workers from unionising. " 2145 2602 W4224209747.pdf 2 19 separator 0.5548204 ¶ 2602 2603 W4224209747.pdf 2 20 text 0.99925476 "Non-governmental organisations (NGOs) and thinktanks such as BILS support social causes and initiatives for workers, undertake research, and make policy recommendations but have more limited influence. The International Labour Organization (ILO) is prominent among international agencies taking an interest in labour rights and employment." 2603 2961 W4224209747.pdf 2 21 separator 0.99707454 ¶ 2961 2963 W4224209747.pdf 2 22 title 0.9926558 3 The beauty parlour sector 2963 2991 W4224209747.pdf 2 23 separator 0.99548304 ¶ 2991 2993 W4224209747.pdf 2 24 text 0.99807465 "The beauty parlour sector, despite being in existence for a very long time, has only recently been recognised as an industrial sector. An estimated 100,000 workers, mostly women, are employed in this sector, which runs on an informal arrangement between the workers and owners. There are no written contracts between parlour workers and owners, resulting in violations of workers’ rights in every parlour in the form of extended working hours, absence of formal salary, leave, and benefit policies. During the pandemic, most staff were on unpaid leave when all parlours were forced to close their doors." 2993 3633 W4224209747.pdf 2 25 separator 0.99686015 ¶ 3633 3635 W4224209747.pdf 2 26 title 0.9935113 Existing data gaps and research opportunities 3635 3681 W4224209747.pdf 2 27 separator 0.99224305 ¶ 3681 3683 W4224209747.pdf 2 28 text 0.9940633 "There is a significant lack of research conducted on the beauty industry in Bangladesh. Karmojibi Nari, BIGD, and the ILO are the only three organisations that have researched the sector. The following might be considered for future research in the sector: • Research on what constitutes workers’ rights in this sector. • The mapping of beauty parlours to establish their numbers, location, numbers of workers, working conditions, and safety and security conditions would provide a useful evidence baseline for future research and decision-making. • Studies to explore the scope and design of social protection measures for beauty parlour workers. • Evidence on barriers to collective action by workers and to increasing awareness among workers of their rights." 3683 4489 W4224209747.pdf 2 29 separator 0.99633217 ¶ 4489 4491 W4224209747.pdf 2 30 title 0.99307525 Key stakeholders 4491 4508 W4224209747.pdf 2 31 separator 0.9949732 ¶ 4508 4510 W4224209747.pdf 2 32 text 0.9974806 "The Ministry of Commerce is the key agency responsible for overseeing the beauty industry. The city corporations provide trade licences to individual beauty parlours. DIFE is responsible for the supervision of parlours. There are a few parlour owners’ associations, such as the Beauty Service Owners Association of Bangladesh and the Bangladesh Garo Beauty Parlour Owners Association. Other stakeholders include beauty parlour owners and the workers themselves." 4510 4999 W4224209747.pdf 2 33 separator 0.996773 ¶ 5000 5002 W4224209747.pdf 2 34 title 0.98056906 Research Briefing The Impact of Covid-19 on Labour Rights and Working Conditions in Four Selected Sectors 5002 5108 W4224209747.pdf 2 0 separator 0.6371766 ¶ 1 2 W4224996753.pdf 2 1 paratext 0.5200387 4 5 W4224996753.pdf 2 2 separator 0.510963 ¶ 5 6 W4224996753.pdf 2 3 paratext 0.9769612 "¶ International Journal of Scientific Research and Modern Education (IJSRME) Impact Factor: 7.137, ISSN (Online): 2455 – 5630 (www.rdmodernresearch.com) Volume 7, Issue 1, 2022 38" 8 201 W4224996753.pdf 2 4 separator 0.99097127 ¶ 202 204 W4224996753.pdf 2 5 text 0.99367815 "This can be done only with the help of exploration process about the Workers in the IT sector. Hence the research has done on “A Study on the Measures Taken by Organization, Individual and Job Level to Minimize Attrition in It Industries with Reference to Infopark , Kochi ”" 205 489 W4224996753.pdf 2 6 separator 0.996313 ¶ 490 492 W4224996753.pdf 2 7 title 0.94637716 Objectives: 492 504 W4224996753.pdf 2 8 separator 0.94654715 ¶ 506 508 W4224996753.pdf 2 9 text 0.9976261 " To study the socio -economic details of the employees working in IT industries.  To get an insight into the measures taken by organization, individual and job level to minimize attrition in it industries with reference to Infopark, Kochi." 508 759 W4224996753.pdf 2 10 separator 0.99647975 ¶ 761 763 W4224996753.pdf 2 11 title 0.9795416 Limitations of the Study: 763 789 W4224996753.pdf 2 12 separator 0.9822814 ¶ 791 793 W4224996753.pdf 2 13 text 0.99719816 "Every study will have its own advantages and disadvantages. The following are the limitations of the study:  The result of the study is based upon the views expressed by the IT employees in Infopark, Kochi.  The statistical tools used to analysis the data have their own limitations .  All the limitations of primary data are applicable to this study." 793 1171 W4224996753.pdf 2 14 separator 0.9962909 ¶ 1173 1175 W4224996753.pdf 2 15 title 0.9874352 Research Methodology: 1175 1197 W4224996753.pdf 2 16 separator 0.9781678 ¶ 1199 1201 W4224996753.pdf 2 17 title 0.89783937 Area of the Study: 1201 1220 W4224996753.pdf 2 18 separator 0.7923846 ¶ 1222 1224 W4224996753.pdf 2 19 text 0.99925464 The research study was done in Infopark , Kochi. 1224 1274 W4224996753.pdf 2 20 separator 0.99325645 ¶ 1276 1278 W4224996753.pdf 2 21 title 0.9420614 Sample Size: 1278 1291 W4224996753.pdf 2 22 separator 0.8463249 ¶ 1294 1296 W4224996753.pdf 2 23 text 0.9994316 A sample of 100 respondents was collected using random sampling method. 1296 1368 W4224996753.pdf 2 24 separator 0.99607855 ¶ 1370 1372 W4224996753.pdf 2 25 title 0.96462363 Nature and Source of Data: 1372 1399 W4224996753.pdf 2 26 separator 0.92978674 ¶ 1401 1403 W4224996753.pdf 2 27 text 0.9992703 "The study is based on questionnaire method; primary data has been collected from various IT sector employees in Infopark, Kochi. And the secondary data have been collected from related journals, websites, Magazines and textbooks." 1403 1640 W4224996753.pdf 2 28 separator 0.9962478 ¶ 1642 1644 W4224996753.pdf 2 29 title 0.93915355 Statistical Tools Used for the Study: 1644 1682 W4224996753.pdf 2 30 table 0.6168217 ¶  Simple 1684 1695 W4224996753.pdf 2 31 text 0.5180462 1695 1696 W4224996753.pdf 2 32 table 0.6564307 "percentage analysis  T-test" 1696 1728 W4224996753.pdf 2 33 separator 0.99342746 ¶ 1729 1731 W4224996753.pdf 2 34 title 0.9491742 Analysis and Interpretation : 1731 1761 W4224996753.pdf 2 35 separator 0.98887 ¶ 1762 1764 W4224996753.pdf 2 36 title 0.9847333 Table 1: Socio Economic Profile of the respondents 1764 1816 W4224996753.pdf 2 37 separator 0.8629843 ¶ 1818 1820 W4224996753.pdf 2 38 table 0.9951483 "Gender Frequency Percent Cumulative Percent age Male 45 47.9 47.9 Female 49 52.1 100.0 Marital Status Married 41 43.6 43.6 Unmarried 53 56.4 100.0 Age 18to 25 45 47.9 47.9 26to 35 38 40.4 88.3 36to 45 11 11.7 100.0 Education Professional 53 56.4 56.4 UG 30 31.9 88.3 PG 11 11.1 100 Experience of Employees 0 – 5 42 44.7 44.7 6 – 10 33 35.1 79.8 11 – 15 14 14.9 94.7 Above15 5 5.3 100.0" 1820 2291 W4224996753.pdf 2 39 separator 0.98613435 ¶ 2293 2295 W4224996753.pdf 2 40 title 0.9829876 Source: Primary Data 2295 2318 W4224996753.pdf 2 41 separator 0.9881326 ¶ 2320 2322 W4224996753.pdf 2 42 title 0.883391 Interpretation 2322 2337 W4224996753.pdf 2 43 text 0.5126379 : 2337 2338 W4224996753.pdf 2 44 separator 0.9349256 ¶ 2340 2342 W4224996753.pdf 2 45 text 0.9981223 "The above table describes gender wise classification of the respondents. It shows the majority 52.1% of the respondents are female. The remaining 47.9% of the respondents are male. From the above table, it is inferred that majority 56.4% of respondents were unmarried and 43.6% of respondents were married . The age groups of the respondents are classified as 18 -25 years, 26 -35 years, 36 -45 years and above 45 years as shown in above table. The highest percentages of 47.9% of the respondents sel ected for the study are 18 -25 years of age, 40.4% of respondents are 26 -35 years of age and 11.7% of respondents are 36-45 years of age. The above table shows there respondents educational Post graduate. The majority 56.4% of the respondents was professional . 31.9% of the respondents were PG and 11.7% of the respondents were studied UG. The Employees experience is classified as below 5 years, 6 -10 years, 11 -15 years and above 15 years. The table 4.7 shows that 44.7% of the respondents were having below 5 years of experience. 35.1% of respondents were having 6 -10 years of experience.14.9% of the respondents were having 11 -15 years of experience and 5.3% of respondents were" 2342 3614 W4224996753.pdf 2 0 paratext 0.9874586 Information 2019 ,10, 138 15 of 16 0 34 W2938645573.pdf 14 1 separator 0.9905158 ¶ 34 36 W2938645573.pdf 14 2 bibliography 0.997935 "11. Cantner, U.; Graf, H. The network of innovators in Jena: An application of social network analysis. Res. Policy 2006 ,35, 463–480. [CrossRef]" 36 184 W2938645573.pdf 14 3 separator 0.8978316 ¶ 184 186 W2938645573.pdf 14 4 bibliography 0.9980044 "12. Hadjimanolis, A.; Dickson, K. Development of national innovation policy in small developing countries: The case of Cyprus. Res. Policy 2001 ,30, 805–817. [CrossRef]" 186 357 W2938645573.pdf 14 5 separator 0.9404038 ¶ 357 359 W2938645573.pdf 14 6 bibliography 0.9977219 "13. Chen, J. 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Available online: http: //www.gov.cn /premier /2019-03 /16/content_5374314.htm 4451 4561 W2938645573.pdf 14 53 separator 0.8833337 ¶ 4561 4563 W2938645573.pdf 14 54 bibliography 0.98714674 (accessed on 11 April 2019). 4563 4592 W2938645573.pdf 14 0 separator 0.8934627 "¶ ¶ ¶ ¶ ¶" 1 30 W4320491104.pdf 8 1 paratext 0.60554814 Test Image 30 41 W4320491104.pdf 8 2 title 0.57126427 Test description 42 59 W4320491104.pdf 8 3 separator 0.9958954 ¶ 61 63 W4320491104.pdf 8 4 title 0.97036463 Push up test 63 76 W4320491104.pdf 8 5 separator 0.9871231 ¶ 78 80 W4320491104.pdf 8 6 text 0.9963087 "The participant was asked to perform as many push ups as he could in one minute." 81 165 W4320491104.pdf 8 7 separator 0.9951565 ¶ 167 169 W4320491104.pdf 8 8 title 0.9816408 Oblique sit up test 169 189 W4320491104.pdf 8 9 separator 0.9874526 ¶ 191 193 W4320491104.pdf 8 10 text 0.9948407 "The participant was asked to perform as many oblique sit ups as he could in one minute. The participant was permitted to stabilise his legs during the sit up if he wished." 194 375 W4320491104.pdf 8 11 separator 0.9411803 "¶ ¶ ¶ ¶" 377 400 W4320491104.pdf 8 0 paratext 0.9874953 30 ISSN 1028-821X. Radio fi z. Electron. 2020. Vol. 25, No. 3А.С. Брюховецький , О.В. Вічкань 0 92 W4243291389.pdf 4 1 separator 0.9940144 ¶ 92 94 W4243291389.pdf 4 2 text 0.9816145 Формула (34) в цих позначеннях виглядає так: 94 139 W4243291389.pdf 4 3 separator 0.95023394 ¶ 139 141 W4243291389.pdf 4 4 math 0.9308236 "211(, ;, ) ( / ) . 41Grr tt t R c R   (36)" 141 204 W4243291389.pdf 4 5 separator 0.9575086 ¶ 204 206 W4243291389.pdf 4 6 text 0.9895108 "У роботі [1] формули (1.91) і (1.96) для збіж- ного розв’язку мають вигляд:" 206 284 W4243291389.pdf 4 7 separator 0.92719793 ¶ 284 286 W4243291389.pdf 4 8 math 0.9456836 "1(, ; , ) ( / ) .Grr tt t R c R (37)" 286 334 W4243291389.pdf 4 9 separator 0.9578382 ¶ 334 336 W4243291389.pdf 4 10 text 0.9612565 "Порівняння вказує на відсутність множників 1 4 і 21 1 з причин, що обговорювалися в роботі про монохроматичне джерело звуку [3]." 336 481 W4243291389.pdf 4 11 separator 0.9948241 ¶ 481 483 W4243291389.pdf 4 12 title 0.98602664 "3. Загальний випадок неточкового джере- ла." 483 529 W4243291389.pdf 4 13 text 0.996706 "У загальному випадку, коли Q не є добут- ком  -функцій (3), розв’язок рівняння (1) да- ється «хвильовим потенціалом»" 529 651 W4243291389.pdf 4 14 separator 0.95952487 ¶ 651 653 W4243291389.pdf 4 15 math 0.9612815 (,) (, ; , ) ( , ) .r t d r d t G r rt tQ rt        (38) 653 728 W4243291389.pdf 4 16 separator 0.9758259 ¶ 728 730 W4243291389.pdf 4 17 text 0.9958033 "Дійсно, підстановка (38) в ліву частину хви- льового рівняння (1) з урахуванням розкладан-ня (8) приводить до виразу" 730 849 W4243291389.pdf 4 18 separator 0.9611488 ¶ 849 851 W4243291389.pdf 4 19 math 0.95572144 "3 2 3,( , ) (2 ) exp ( ) ( ) ( , ) 1() ( 2 ) (2 ) () 2 ( ) ( , ) ( , ) .dK dLr t d r d t L Gt iK r r i t t Q r t dr dt z z rr t t Q r t Q r t                                           " 851 1167 W4243291389.pdf 4 20 separator 0.9652045 ¶ 1167 1169 W4243291389.pdf 4 21 text 0.9873301 "Для отримання (39) були прийняті до уваги рівність (9) і співвідношення повноти (6)." 1169 1257 W4243291389.pdf 4 22 separator 0.9453302 ¶ 1257 1259 W4243291389.pdf 4 23 text 0.9795899 "Підставляючи (34) у «хвильовий потенціал» (38), можна привести його до вигляду:" 1259 1342 W4243291389.pdf 4 24 separator 0.91869855 ¶ 1342 1344 W4243291389.pdf 4 25 math 0.9565177 "2111(,) ( , ) .ˆ41rt d r Q r trM      (40)" 1344 1406 W4243291389.pdf 4 26 separator 0.82595885 ¶ 1406 1408 W4243291389.pdf 4 27 text 0.910629 Для точкового джерела з залежністю від часу 1408 1452 W4243291389.pdf 4 28 separator 0.48988158 ¶ 1453 1455 W4243291389.pdf 4 29 math 0.9109756 "()ft 0 (,) ( )( ) .Qr t ft r r     (41)" 1455 1508 W4243291389.pdf 4 30 separator 0.93298155 ¶ 1508 1510 W4243291389.pdf 4 31 text 0.95001394 "Формула (40) після інтегрування за dr при- водить до результату" 1510 1578 W4243291389.pdf 4 32 separator 0.7660816 ¶ 1578 1580 W4243291389.pdf 4 33 math 0.94789153 "021011(,) ( ) ,ˆ41rt f trM    (42) де 010 1ˆˆ ,rrrr 00 (, ; ) .rrrr MДля" 1580 1689 W4243291389.pdf 4 34 text 0.81402683 "монохроматичного імпульсу прямокут- ної форми тривалістю t з несучою часто- тою" 1689 1774 W4243291389.pdf 4 35 math 0.9532019 "0 0 00 () ( ) ( )itft e Ut t Ut t t       отримуємо 00() 00 0 00() ( ) () .itft e Ut t Ut t t          (43)" 1774 1937 W4243291389.pdf 4 36 separator 0.9733124 ¶ 1937 1939 W4243291389.pdf 4 37 text 0.9749241 "Тут ()Ut  одинична ступінчаста функція Хевісайда, 00tt  момент часу приходу з точки 0r в т о ч к у r переднього хвильового фронту, а 00tt t      заднього." 1939 2123 W4243291389.pdf 4 38 separator 0.64634776 ¶ 2123 2125 W4243291389.pdf 4 39 text 0.9807608 "Для 00 00tt t t   добуток функ- цій Хевісайда у формулі (43) дорівнює одини-ці, і ця формула приводить до результату" 2125 2255 W4243291389.pdf 4 40 separator 0.5969399 ¶ 2255 2257 W4243291389.pdf 4 41 math 0.9130989 "00() 21011(,) ,ˆ41itrt erM    (44)" 2257 2308 W4243291389.pdf 4 42 separator 0.5263706 ¶ 2308 2310 W4243291389.pdf 4 43 text 0.9893643 "який (з точністю до знака джерела) збігається, маючи на увазі 0 з (33), зі значенням (,) ,rt що надається формулою (62) в [3] для порушу-ваних монохроматичним джерелом усталених звукових коливань." 2310 2516 W4243291389.pdf 4 44 separator 0.93877435 ¶ 2516 2518 W4243291389.pdf 4 45 text 0.988172 "Точки спостереження ,r до яких випроміне- не в момент часу t коливання надходить із за- пізненням (, , ) ,rr M  утворюють поверхню, рівняння якої в момент часу спостереження t визначається нулями  -функції в (34):" 2518 2753 W4243291389.pdf 4 46 separator 0.6581942 ¶ 2753 2755 W4243291389.pdf 4 47 math 0.9423152 (, , ) 0 . tt r r M  (45) 2755 2793 W4243291389.pdf 4 48 separator 0.9739264 ¶ 2793 2795 W4243291389.pdf 4 49 text 0.96890885 "Вигляд цієї поверхні легко встановити в разі спеціального вибору системи координат, напря- мок осі z якої збігається з напрямком ,M тобто з напрямком . У цьому випадку (0,0, ) MM ¶ і (45) записуються таким чином:" 2795 3028 W4243291389.pdf 4 50 separator 0.9120227 ¶ 3028 3030 W4243291389.pdf 4 51 math 0.95380485 "11 2 2ˆ 10, 1 1 aMz rttc M M        (46) де 2 1 22 11 1 2ˆ . 1zrx y M  " 3030 3143 W4243291389.pdf 4 52 separator 0.7859684 ¶ 3143 3145 W4243291389.pdf 4 53 text 0.9331373 "Якщо початок відліку системи координат збігається з джерелом (0 ) ,r то 1 ." 3145 3227 W4243291389.pdf 4 54 math 0.6539561 rr 3227 3233 W4243291389.pdf 4 55 text 0.876809 "¶ У результаті елементарних перетворень (46) отримуємо" 3233 3291 W4243291389.pdf 4 56 separator 0.6291222 ¶ 3291 3293 W4243291389.pdf 4 57 math 0.9257933 22 2 2() , ca zz r c t    (47) 3293 3330 W4243291389.pdf 4 58 separator 0.40966684 ¶ 3330 3332 W4243291389.pdf 4 59 text 0.93171465 "де tt t  різниця моментів часу спо- стереження і випромінювання коливання, а" 3332 3417 W4243291389.pdf 4 60 separator 0.63452125 ¶ 3418 3420 W4243291389.pdf 4 61 math 0.92898494 . cazM c t t  (39) 3420 3444 W4243291389.pdf 4 0 paratext 0.97794485 "5 Vol.:(0123456789) Scientific Reports | (2022) 12:10714 | https://doi.org/10.1038/s41598-022-14663-3 www.nature.com/scientificreports/" 0 148 W4283376999.pdf 4 1 text 0.9991155 "Although the canine tooth has been taken as a model for investigating OTM in a substantial number of researches, the differential rate of retraction of contralateral canines, and the severe tipping of the crown com - pared to the root movement was a common finding. Besides, though the difference in retraction pattern between the sliding and frictional mechanics which have been widely stated in the literature, there is no sound explana- tion of these phenomena57,60. This recurring finding triggered the assumption that a discreet factor might be controlling OTM. Hence, the current observational study was conducted to investigate three dimensionally the relationship between the canine root and the labial cortical plate of bone before and after maxillary canine retraction using conventional mechanics." 148 976 W4283376999.pdf 4 2 separator 0.9893774 ¶ 976 978 W4283376999.pdf 4 3 text 0.999479 "In the current observational study, 42 patients with 84 bilateral maxillary canines were enrolled. The patients’ orthodontic treatment plan necessitated extraction of maxillary first premolars and retraction of maxillary canines. Conventional orthodontic mechanics were applied using NiTi retraction spring delivering a force of 150 g. Three-dimensional CBCT were collected prior to and after canine retraction yielding 168 observations of the canine. The pre-retraction and post-retraction CBCT were superimposed on stable skeletal structures." 978 1535 W4283376999.pdf 4 4 separator 0.9965197 ¶ 1535 1537 W4283376999.pdf 4 5 caption 0.99220043 Figure 5. Examples of CRCR Grade C. 1537 1574 W4283376999.pdf 4 6 separator 0.99547476 ¶ 1574 1576 W4283376999.pdf 4 7 title 0.8701205 Table 3. Shows the total number of the canine root/cortical bone grades in the pre- and post-retraction 1576 1681 W4283376999.pdf 4 8 table 0.4318717 ¶ 1682 1684 W4283376999.pdf 4 9 title 0.585736 CBCT’s 1684 1691 W4283376999.pdf 4 10 table 0.98553514 ".Pre-retraction Post-retraction Total Total % Percentages Grade A 5 4 9 5.3 5.4 Grade B 19 8 27 16.1 94.6 Grade C 60 72 132 78.6" 1691 1827 W4283376999.pdf 4 11 separator 0.99069613 ¶ 1827 1829 W4283376999.pdf 4 12 title 0.7754994 Table 4. Showing the change of the grade of the canine root and root apices from the pre- to the post- 1829 1935 W4283376999.pdf 4 13 table 0.49198604 ¶ 1935 1936 W4283376999.pdf 4 14 title 0.64300334 retraction position for the same subjects 1936 1978 W4283376999.pdf 4 15 table 0.9801192 ".PrePost Grade A Grade B Grade C Grade A (5) 1 0 4 Grade B (19) 2 6 11 Grade C (60) 1 2 57" 1978 2076 W4283376999.pdf 4 0 paratext 0.79401165 Reed HM (2018) Large squamous papilloma involving a transgender neovagina Volume 2(1): 2-2 0 90 W2795607298.pdf 1 1 separator 0.9787147 ¶ 90 92 W2795607298.pdf 1 2 paratext 0.75199467 Surg Case Rep Rev, 2018 doi 92 135 W2795607298.pdf 1 3 text 0.70749456 : 135 136 W2795607298.pdf 1 4 paratext 0.85491943 10.15761/SCRR.1000111 136 158 W2795607298.pdf 1 5 text 0.9954887 "of cases involved HPV virus serotypes 6 and 11. With HPV 6 and 11 the potential for malignant transformation is low. 118 papilloma viruses have been completely described and many more are suspected to exist by subgenomic aplicons [4]. They can cause warts as well as papillomas and may exist without being grossly visible [5]." 158 496 W2795607298.pdf 1 6 separator 0.94820744 ¶ 497 499 W2795607298.pdf 1 7 text 0.9983899 "The National Cancer Institute has recommended routine 3 dose HPV vaccination (type 9vHPV) at age 11 or 12 years [6]. For those not previously vaccinated or those who have not completed the 3-dose course, females aged 13 through 26 years and of males aged 13 through 21 years may be vaccinated." 499 802 W2795607298.pdf 1 8 separator 0.7862761 ¶ 803 805 W2795607298.pdf 1 9 text 0.9974371 "HPV vaccination and condom usage of is recommended for vaginoplasty patients. through age 26 years as well as men who have sex with men and for immunocompromised persons if not vaccinated previously. The quadrivalent (qHPV) vaccine Gardasil (Merck) also protects against HPV types 6 and 11 [7-9].A p16 immunohistochemistry (IHC) is recommended by the American Society for Colposcopy and Cervical Pathology (ASCCP) when the H&E morphologic differential diagnosis is between precancer and a mimic of precancer (such as atrophy and reparative epithelial changes); a strong and diffuse block-positive P16 result supports a categorization of precancerous disease.” [2]. While the papilloma in our patient did not disclose atypia or suggestion of a precancerous lesion, a p16 IHC stain was performed as an academic adjunct. " 805 1639 W2795607298.pdf 1 10 separator 0.5382451 ¶ 1639 1640 W2795607298.pdf 1 11 text 0.99850637 "Removal of the entire lesion and expert pathologic review is strongly advised before treatment is initiated [10]." 1640 1757 W2795607298.pdf 1 12 separator 0.99615735 ¶ 1757 1759 W2795607298.pdf 1 13 title 0.9849714 Conclusion 1759 1770 W2795607298.pdf 1 14 separator 0.99656093 ¶ 1770 1772 W2795607298.pdf 1 15 text 0.99857676 "HPV induced squamous papilloma occur frequently in the anogenital area. They are often invisible, are sexually transmitted, and typically benign. Their duration may be brief and self-limiting. Such lesions may grow to an unusually large size. Concurrent malignancy justifies excisional biopsy." 1772 2078 W2795607298.pdf 1 16 separator 0.99607223 ¶ 2078 2080 W2795607298.pdf 1 17 title 0.8833784 Funding 2080 2088 W2795607298.pdf 1 18 separator 0.98333395 ¶ 2088 2090 W2795607298.pdf 1 19 bibliography 0.27215388 Non 2090 2094 W2795607298.pdf 1 20 text 0.4946686 e 2094 2095 W2795607298.pdf 1 21 separator 0.99344504 ¶ 2095 2097 W2795607298.pdf 1 22 title 0.8312069 References 2097 2108 W2795607298.pdf 1 23 separator 0.99425745 ¶ 2108 2110 W2795607298.pdf 1 24 bibliography 0.9976524 1. Braun H, Nash R, Tangpricha V (2017) Cancer in Transgender People: Evidence and Methodological Considerations. Epidermiol Review 39: 93-107 [Crossref] 2110 2265 W2795607298.pdf 1 25 separator 0.943496 ¶ 2265 2267 W2795607298.pdf 1 26 bibliography 0.9980218 "2. Darragh TM, Colgan TJ, Cox JT, Heller DS, Henry MR, et al. (2013) The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: background and consensus recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology. Int J Gynecol Pathol 32: 76-115 [Crossref]" 2267 2623 W2795607298.pdf 1 27 separator 0.9814173 ¶ 2623 2625 W2795607298.pdf 1 28 bibliography 0.9979723 3. Susan Hariri, Eileen Dunne, Mona Saraiya, Elizabeth Unger, Lauri Markowitz (2011) Manual for the Surveillance of Vaccine-Preventable Diseases, Centers for Disease Control and Prevention, Department of Health and Human Services, VPD Surveillance Manual, 5th Edition, 5 Human Papillomavirus: Chapter 5-1 2625 2930 W2795607298.pdf 1 29 separator 0.97314537 ¶ 2931 2933 W2795607298.pdf 1 30 bibliography 0.99786377 4. DermNet New Zealand, Squamous Cell Papilloma, Ngan, Vanessa 2005 2933 3001 W2795607298.pdf 1 31 separator 0.6797941 ¶ 3001 3003 W2795607298.pdf 1 32 bibliography 0.9978016 "5. Rocky bacelieri (2005) Cutaneous warts: an evidence-based approach to therapy Am Fam Physician. 72: 647-652. [Crossref]" 3003 3130 W2795607298.pdf 1 33 separator 0.9635161 ¶ 3130 3132 W2795607298.pdf 1 34 bibliography 0.99799615 6. De Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H (2004) Classification of papillomaviruses 3132 3240 W2795607298.pdf 1 35 separator 0.85226053 ¶ 3241 3243 W2795607298.pdf 1 36 bibliography 0.99751455 "7. Petrosky E, Bocchini JA, Hariri S (2015) Use of 9-Valent Human Papillomavirus (HPV) Vaccine: Updated HPV Vaccination Recommendations of the Advisory Committee on Immunization Practices. Morbidity and Mortality Weekly Report 64: 300-304. [Crossref]" 3243 3503 W2795607298.pdf 1 37 separator 0.98280716 ¶ 3503 3505 W2795607298.pdf 1 38 bibliography 0.99808127 8. Oelschlager AA, Kirby A, Breech L (2017) Evaluation and Management of Vaginoplasty Complications. Curr Opin Obstet Gynecol. 29: 316-321 [Crossref] 3505 3655 W2795607298.pdf 1 39 separator 0.95272166 ¶ 3655 3657 W2795607298.pdf 1 40 bibliography 0.99808764 9. Chia-ching JW, Palefsky JM (2015) Human Papillomavirus (HPV) Infections and the Importance of HPV Vaccination Curr Epidemiol Rep 2: 101-109 [Crossref] 3657 3811 W2795607298.pdf 1 41 separator 0.96964765 ¶ 3811 3813 W2795607298.pdf 1 42 bibliography 0.9979253 "10. Indres MT, Deligdisch L, Altchek (2009) A Squamous Papilloma with Hyperpigmentation in the Skin Graft of the Neovagina in Rokitansky Syndrome. J Pediatr Adolesc Gynecol 22: e148-e155 [ Crossref]" 3813 4016 W2795607298.pdf 1 43 separator 0.98946464 ¶ 4016 4018 W2795607298.pdf 1 44 caption 0.9895238 Figure 2. Gross B: Cut surfaces 4018 4051 W2795607298.pdf 1 45 separator 0.68943655 ¶ 4051 4053 W2795607298.pdf 1 46 caption 0.9855381 Figure 3. Micro: H 4053 4073 W2795607298.pdf 1 47 separator 0.93584335 ¶ 4073 4075 W2795607298.pdf 1 48 paratext 0.9670467 "Copyright: ©2018 Reed HM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited." 4075 4340 W2795607298.pdf 1 0 text 0.9995142 "mento, que dista cerca de doze quilômetros dessa vila, até a idade de três anos. Nessa ocasião acompanhou os pais, ao se mudarem para a localidade da Praia no município de Iguape, ali ficando por tempo inferior a um ano, findo o qual passou a residir no endereço atual. Freqüenta a escola de primeiro grau mostrando comportamento normal para a idade. Mediante informações colhidas de familiares, sua história pre- gressa assinala apenas quadros possivel- mente amastiformes nos primeiros anos de vida, além de anemia e anasarca em deter- minada oportunidade. Chamou a atenção o relato de que, no ano passado (1980), teria sofrido fenômeno febril revelado por acessos noturnos, sem a presença de outros sin- tomas, e com remissão durante o dia. O caso foi detectado quando da realização de uma das etapas do inquérito sorológico escolar em municípios do Estado, levado a efeito pela SUCEN, e baseado na coleta de sangue para o exame de imunofluores- cência indireta. Assim é que, em agosto de 1980, a amostra dos escolares da região forneceu, para ACC, resultado considerado duvidoso. Em vista disso, procedeu-se à segunda coleta em dezembro do mesmo ano e atingindo também seus familiares. Todos estes forneceram resultados negativos, mas o menor teve reação positiva de título 1/160." 0 1344 W3033691673.pdf 1 1 separator 0.95119643 ¶ 1344 1346 W3033691673.pdf 1 2 text 0.99956787 "Durante a presente investigação, fez-se nova coleta do caso, obtendo-se novo resultado positivo com título de 1/512. O exame físico revelou bom estado geral, sem qualquer alteração digna de nota. Não foi possível evidenciar a porta de entrada da infecção,tendo sido negados antecedentes operatórios ou de transfusão sangüínea. A reação de fixação de complemento foi positiva, bem assim a aglutinação direta ( > 64) e o xenodiagnóstico. Iniciou o tratamento em 7.IV. 81, com benzomidazol na posologia de 8,7mg/Kg/dia." 1346 1885 W3033691673.pdf 1 3 separator 0.9889878 ¶ 1885 1887 W3033691673.pdf 1 4 title 0.9939464 INVESTIGAÇÃO E COMENTÁRIOS 1887 1914 W3033691673.pdf 1 5 separator 0.9955981 ¶ 1914 1916 W3033691673.pdf 1 6 text 0.99970627 "Durante a inquirição dos familiares foi referido que, quando a família residia no Sítio Araçauba, alimentava-se com freqüên- cia de animais silvestres, entre os quais figuravam tatus. Nessas oportunidades, o menor ACC participava do preparo das carnes para as refeições. Por duas vezes, em dezembro de 1980 e março de 1981, foram realizadas buscas de triatomíneos na Vila São José — Ariri, com resultados total- mente negativos. Por sua vez, os moradores negam a existência de focos domiciliados desses insetos. Quatro cães encontrados nas casas locais foram submetidos ao xeno- diagnóstico, com resultados negativos." 1916 2562 W3033691673.pdf 1 7 separator 0.916054 ¶ 2562 2564 W3033691673.pdf 1 8 text 0.99967635 "Diante desses achados é forçoso admitir o caráter autóctone regional do caso bem como de mecanismo de transmissão outro que não a ação triatomínea. As caracterís- ticas locais e os hábitos da população, em todo análogas ao do caso anteriormente descrito, levam à supor a contaminação por meio de mamíferos silvestres utilizados na alimentação. De qualquer maneira, este novo achado parece confirmar a hipótese de exis- tência de quadro regional endêmico de tripanossomíase americana." 2564 3070 W3033691673.pdf 1 9 separator 0.99704874 ¶ 3070 3072 W3033691673.pdf 1 0 text 0.99316657 "171 ference, but at least three things appeared to pass by common consent: (I) } different grades of commercial instruction should be suited to the needs of different classes and to this end at least three sorts of institutions should be provided: high schools of commerce, colleges of commerce and post-graduate schools of commerce; (2) for the first two institutions just named, technical and special elements should not too much exclude the general and cultural work (a proportion given for the college of commerce was 60 per cent of general work, and 40 per cent of special) ; and (3) the traditions and condi- tions of each community and institution must largely guide in dealing with its local problem." 0 728 W2029599101.pdf 0 1 separator 0.9607495 ¶ 728 730 W2029599101.pdf 0 2 text 0.99873114 "Mention should be made of the gracious and diplomatic manner in which the president of the Michigan Political Science Association, Hon. Arthur Hill, of Saginaw, presided over the convention, and the skillful steering com- mittee work of Professor Adams as secretary. The visiting delegates carried away pleasant memories of the hospitality of President Angell and the Michigan faculty. The papers and discussions of the meeting will be pub- lished by the Michigan Political Science Association." 730 1237 W2029599101.pdf 0 3 separator 0.98775125 ¶ 1237 1239 W2029599101.pdf 0 4 contact 0.41692767 Central High School, Pkiladelpkia 1239 1273 W2029599101.pdf 0 5 paratext 0.3742499 CHEE 1273 1277 W2029599101.pdf 0 6 contact 0.41732657 SMAN A 1277 1283 W2029599101.pdf 0 7 paratext 0.40461528 . HER 1283 1288 W2029599101.pdf 0 8 contact 0.37784824 RICK 1288 1292 W2029599101.pdf 0 9 paratext 0.5445488 . 1292 1293 W2029599101.pdf 0 10 separator 0.9454854 ¶ 1293 1295 W2029599101.pdf 0 11 title 0.99277 TRAINING IN AGRICULTURE AT TUSKEGEE 1295 1331 W2029599101.pdf 0 12 separator 0.9948263 ¶ 1331 1333 W2029599101.pdf 0 13 text 0.9977216 "In the article on the &dquo;Evolution of Negro Labor,&dquo; by Mr. Carl Kelsey, published in the January number of THE ANNALS, the statement is made that &dquo;even Tuskegee is not doing so much in this line (training agriculturists) as generally supposed, in spite of the emphasis I know is being laid upon it. In examining its last catalogue I find only sixteen graduates who are farming; of these, thirteen have other occupations, principally teaching. Three others are introducing cotton raising in Africa under the German government. From the industrial department nine have received certificates in agriculture and six in dairying, but their present occupations are not given.&dquo;" 1333 2038 W2029599101.pdf 0 14 separator 0.93309414 ¶ 2038 2040 W2029599101.pdf 0 15 text 0.99487513 "It may be interesting in view of this comment for readers of THE ANNALS to know what Tuskegee is now doing to train agriculturists. This year the students in agriculture in the institute fall into three groups: (I) 181 students are engaged in the actual operation of the farm, the truck garden, the orchard, etc.; (2) 79 students are taking &dquo;the professional courses&dquo;; and (3) 207 students are taking agriculture as a regular part of their academic work. This statement has eliminated the counting of the same person twice and, therefore, shows, as far as enrollment goes, what the school is now doing in agriculture." 2040 2684 W2029599101.pdf 0 16 separator 0.9603583 ¶ 2684 2686 W2029599101.pdf 0 17 text 0.99963516 "But Mr. Kelsey bases his comment upon the unfortunately meagre state- ment contained in last year’s catalogue as to occupations in which our grad- uates are engaged. This is a clearly inadequate test of the efficiency of the work here because for easily understood reasons-and poverty is not the ieast-our students in very few cases remain throughout the course. The Senior Class;-the course is seven years in length,-in February, 1902, repre- sented less than 4/ per cent of the total undergraduate enrollment." 2686 3210 W2029599101.pdf 0 18 paratext 0.47765338 Of 3210 3213 W2029599101.pdf 0 19 text 0.86632466 the ¶ 3213 3219 W2029599101.pdf 0 20 paratext 0.94425327 at University of Manitoba Libraries on June 9, 2015 ann.sagepub.com Downloaded from 3220 3304 W2029599101.pdf 0 0 paratext 0.99024874 Int. J. Environ. Res. Public Health 2020 ,17, 1810 5 of 15 0 58 W3011447808.pdf 4 1 separator 0.99547154 ¶ 58 60 W3011447808.pdf 4 2 text 0.9879547 "Assuming interviewee (N) and assigned inquiry amounts ( Bi,BU i,BD i), the log-likelihood function of interviewee i is:" 60 186 W3011447808.pdf 4 3 separator 0.92644656 ¶ 186 188 W3011447808.pdf 4 4 math 0.93854904 "lnLD()=XN i=18>><>>:dYY ilnYY Bi, BU i +dNN ilnNN Bi, BD i +dYN ilnYN Bi, BU i +dNY ilnNY Bi, BD i9>>=>>;. (10)" 188 345 W3011447808.pdf 4 5 separator 0.9756011 ¶ 345 347 W3011447808.pdf 4 6 text 0.865686 "If the interviewee replies willing in both rounds, then dYY i=1,d" 347 415 W3011447808.pdf 4 7 math 0.5401555 NN ¶ 415 419 W3011447808.pdf 4 8 text 0.54027915 i 419 421 W3011447808.pdf 4 9 math 0.56325346 =dYN 421 425 W3011447808.pdf 4 10 text 0.4931038 425 426 W3011447808.pdf 4 11 math 0.47784898 ¶ 426 427 W3011447808.pdf 4 12 text 0.58666885 i 427 429 W3011447808.pdf 4 13 math 0.47901788 = 429 430 W3011447808.pdf 4 14 text 0.84803605 "dNY i=0; conversely, if the interviewee replies unwilling in both rounds, then dNN i=1," 430 523 W3011447808.pdf 4 15 math 0.5742992 "dYY i=dYN ¶" 523 536 W3011447808.pdf 4 16 text 0.5493975 536 537 W3011447808.pdf 4 17 math 0.6047787 i=dNY 537 542 W3011447808.pdf 4 18 text 0.5709145 542 543 W3011447808.pdf 4 19 math 0.48173872 ¶ 543 544 W3011447808.pdf 4 20 text 0.81591284 "i=0; therefore, dYN" 544 566 W3011447808.pdf 4 21 math 0.4997486 ¶ 566 568 W3011447808.pdf 4 22 text 0.6583157 iand dNY 568 577 W3011447808.pdf 4 23 math 0.50180984 ¶ 577 579 W3011447808.pdf 4 24 text 0.6568553 i. 579 582 W3011447808.pdf 4 25 separator 0.9778913 ¶ 582 584 W3011447808.pdf 4 26 text 0.9837018 "The first-order equilibrium solution (@lnLD ˆD @=0)is taken from the log-likelihood function (lnLD(ˆD)) against the estimator ()to obtain the maximum approximate estimator ˆD. The asymptotic variance covariance matrix of ˆDis expressed as:" 584 839 W3011447808.pdf 4 27 separator 0.7742323 ¶ 839 841 W3011447808.pdf 4 28 math 0.69848746 VD(ˆD) = [ 841 853 W3011447808.pdf 4 0 text 0.99941343 "In Table 4, model (1) includes the influence of firm characteristics and shows that the value of total assets is negatively related to the firm recovery rate, but thecoefficient is insignificant. Both asset structure variables, fraction of fixed assets and quick ratio, have significantly positive coefficients. The fraction of fixed assets is likely to have a positive sign, because it is a proxy for saleable assets and alsoinversely related to intangible assets. For the quick ratio we also hypothesize apositive effect on recovery, because companies with more liquid assets have ahigher recovery potential. Obviously, for leverage (Debt) we predict a negativecoefficient, as more indebted firms have simply more debt to recover. However, wehypothesize a positive effect of bank debt, because banks will put in more effort inthe recovery process in case their part of the total liabilities is larger. The estimates corroborate our hypothesized effects. Particularly, the coefficient of bank debt of 0.313 is high. In case a firm has the median amount of bank debt of 21.4%, therecovery rate is 6.7% point (21.4 times 0.313) higher, in comparison with a firmwithout bank debt. The adjusted R 2of the model is 0.250." 0 1215 W2158931222.pdf 16 1 separator 0.9896507 ¶ 1215 1217 W2158931222.pdf 16 2 text 0.9990795 In model (2) we drop insignificant variables and include time-related variables. 1217 1297 W2158931222.pdf 16 3 separator 0.6168039 ¶ 1297 1299 W2158931222.pdf 16 4 text 0.99960685 "None of these variables obtain significance. Clearly, both the length of thebankruptcy process and the time to sell assets do not influence the recovery rates. Inmodel (3), we introduce the procedural characteristics. Continuation in bankruptcy is hypothesized to be positive for the recovery rate, because it indicates that the firm has valuable activities, which may yield higher asset prices. The liquidation dummyis expected to yield a negative coefficient, because realized values are normallylower in piecemeal liquidations, compared to going concern asset sales. We find thatthe variables continuation in bankruptcy and piecemeal liquidation are significant,respectively at 5% and 10% level. Both coefficients also have the hypothesized sign.The levels of the coefficients imply that the recovery rate increases by 8.1% pointwhen the trustee continues the operations and decreases by 6.1% point in case of liquidation. Given that the average recovery rate is 37.2%, these two variables have a major impact on the creditors’ proceeds. Conflicts, procedures and disputes do notaffect recovery rates, nor does the involvement of management. The adjusted R 2in model (3) is 0.281, which again indicates a minor improvement relative to the firmcharacteristics in model (1). In model (4) we include only the significant variables inprevious models and find that the results are robust." 1299 2686 W2158931222.pdf 16 5 separator 0.98251605 ¶ 2686 2688 W2158931222.pdf 16 6 text 0.9995356 "We find that the firm recovery rate is higher when firms have more fixed assets, a higher quick ratio, are not liquidated and continue their operations in bankruptcy." 2688 2853 W2158931222.pdf 16 7 separator 0.74010086 ¶ 2853 2855 W2158931222.pdf 16 8 text 0.99929047 "These results are in line with expectations. We also find that the effect on recovery is negative for leverage and positive for bank debt. Our results confirm previoustests. Thorburn ( 2000 ) documents that recovery rates in Swedish firms are influenced by secured (bank) debt and the outcome of the procedure. Sundgren(1998 ) finds that indebtedness is a significant determinant of recovery. Bris et al. (2006 ) report similar results with respect to size (not or only weakly relevant), leverage and secured debt. Gilson et al. ( 1990 ) report that distressed exchange offers in the US are more successful when the debt structure is more concentrated, which is in line with our result for bank debt. The results show that even in liquidation-based system it helps to have concentrated bank debt." 2855 3660 W2158931222.pdf 16 9 paratext 0.9760611 Eur J Law Econ (2008) 26:105–127 121 3660 3696 W2158931222.pdf 16 10 separator 0.70268613 ¶ 3696 3698 W2158931222.pdf 16 11 paratext 0.95718473 123 3698 3702 W2158931222.pdf 16 0 paratext 0.9909199 Page 18/27 0 10 W4385930555.pdf 17 1 separator 0.99560434 ¶ 10 12 W4385930555.pdf 17 2 caption 0.95512724 Figure 2 12 21 W4385930555.pdf 17 3 separator 0.933655 ¶ 21 23 W4385930555.pdf 17 4 caption 0.99010307 The growth curve of Radon concentration builds inside the Smart RnDuo monitor 23 101 W4385930555.pdf 17 5 separator 0.99693775 ¶ 101 103 W4385930555.pdf 17 0 paratext 0.9902324 J. Fungi 2021 ,7, 211 5 of 13 0 29 W3135966791.pdf 4 1 separator 0.95361316 ¶ 29 31 W3135966791.pdf 4 2 text 0.9986262 "pg/mL, 7 (3%) were indeterminate and 152 were negative. For Aspergillus real-time PCR there was sufficient volume for testing 156/240 (65%) samples, whereof 39 (25%) were positive with a median (range, IQR) C t37.7 (17.1–41.6, 2.6). Thus, taking into account only the 156 samples tested for all three biomarkers, 88 (56%) were positive in at least one biomarker, whereas only 4 (3%) were positive in all three (Table 1). The four samples were from four patients (two AML, all on antifungal treatment, three with antimold therapy), three with probable IA and one with possible IA and had GM index/PCR C t/BDG pg/mL 1.41/34/119, 0.63/40.1/320, 3.02/28.47/309, 1.53/20.45/84, respectively. The sample positivity rate of BDG was higher in patients with probable (55%) and possible IA (46%) than in patients with no evidence for IA (40%), whereas the positivity rate of PCR was higher in patients with probable IA (55%) than in patients with possible IA (19%) and no evidence for IA (22%). When samples positive to one of the biomarkers were analyzed, significant correlation was found between PCR C tand GM indices (r s=" 31 1170 W3135966791.pdf 4 0 paratext 0.97910196 Editorial - 11- 0 15 W4248561575.pdf 0 1 separator 0.8497871 ¶ 15 17 W4248561575.pdf 0 2 title 0.9786114 EDITORIAL 17 27 W4248561575.pdf 0 3 separator 0.99416006 ¶ 27 29 W4248561575.pdf 0 4 text 0.9985136 "A publicação de um periódico científico requer o cumprimento de vários critérios indispensáveis para a manutenção da qualidade esperada pelos editores, autores, comunidade consumidora, e pelas bases de dados nacionais e internacionais. Atender os requisitos básicos é um desafio que o corpo editorial deve enfrentar a cada número a ser publicado, dentre eles destacam-se: cumprir os prazos de publicação e distribuição conforme a periodicidade prevista; manter a qualidade gráfica; viabilizar um processo de avaliação por pares ágil e de qualidade; manter adequada comunicação com os auto- res; assegurar a qualidade do conteúdo, normalização, atualidade, abrangência (regional, nacional e internacional) e inovação das informações veiculadas." 29 784 W4248561575.pdf 0 5 separator 0.9598255 ¶ 784 786 W4248561575.pdf 0 6 text 0.99959826 "As etapas que envolvem o processo de editoração, desde a submissão do manuscrito até a publi- cação do artigo final requerem um trabalho árduo, comprometido e minucioso . A qualidade de toda essa operação, permeada por muitas facetas “invisíveis”, é avaliada indiretamente pelos consumi - dores do conhecimento divulgado e pelos experts que compõem os comitês de seleção/avaliação dos periódicos das bases de dados, que tem como objeto real de avaliação o “produto”, ou seja, os artigos publicados. A indexação em bases de dados conceituadas em nível nacional e internacional promove a aceitação na comunidade científica e consequente visibilidade do periódico, quando está associada a uma política de acessibilidade – open acess." 786 1524 W4248561575.pdf 0 7 separator 0.9728404 ¶ 1526 1528 W4248561575.pdf 0 8 text 0.9988688 "Assim, cada periódico científico possui um papel fundamental na construção e divulgação do conhecimento, considerando que “o fluxo da comunicação científica inclui a publicação formal de resultados de pesquisa, a recuperação de informação, o acesso à literatura publicada e a comunicação informal e de intercâmbio entre pesquisadores. É um fluxo contínuo, pois conhecimentos publicados e assimilados dão origem a novos conhecimentos, pesquisas e publicações, regido por uma dinâmica específica e influenciado pelas relações com a sociedade”." 1529 2074 W4248561575.pdf 0 9 separator 0.9752934 ¶ 2074 2076 W4248561575.pdf 0 10 paratext 0.9462785 1:58 2076 2081 W4248561575.pdf 0 11 separator 0.99318284 ¶ 2081 2083 W4248561575.pdf 0 12 text 0.99936295 "A Texto & Contexto Enfermagem, publicada desde 1992, teve como grande diferencial qualitati- vo ser uma revista temática, abordando questões importantes para a Enfermagem brasileira, em cada número, sob vários olhares e diferentes ângulos." 2083 2325 W4248561575.pdf 0 13 separator 0.6214385 2325 2326 W4248561575.pdf 0 14 text 0.5831838 ¶ 2 2326 2329 W4248561575.pdf 0 15 separator 0.96614254 ¶ 2330 2332 W4248561575.pdf 0 16 text 0.9996404 "Desde seu início, passou (e continuará passando) por transformações ao longo de sua existên- cia, buscando acompanhar a crescente evolução na produção e fluxo de divulgação da comunicação científica. A trajetória desse periódico tem sido pautada pelo aprimoramento do seu processo de editoração e administrativo, que culminou na publicação trimestral a partir de 2003 para atender a grande demanda de artigos submetidos e consequente necessidade de ampliação de oportunidade para a disseminação do conhecimento. Em 2006, foi aprovada para fazer parte da Scientific Eletronic Library Online (SciELO), estando em acesso aberto nessa coleção a partir de 2007." 2332 2994 W4248561575.pdf 0 17 separator 0.98625696 ¶ 2994 2996 W4248561575.pdf 0 18 text 0.39076522 2 2996 2998 W4248561575.pdf 0 19 bibliography 0.77772284 "A conquista mais recente foi a indexação no ISI - Web of Science®.3" 2998 3069 W4248561575.pdf 0 20 separator 0.9923768 ¶ 3069 3071 W4248561575.pdf 0 21 text 0.9989554 "Todos os esforços têm sido empreendidos para que a Texto & Contexto Enfermagem contribua cada vez mais para a divulgação do conhecimento científico na área da saúde, em especial da enfermagem, procurando aperfeiçoar o seu acesso à comunidade científica. Assim, após 18 anos (1992-2009), focali-zando uma temática específica em cada número, 4 deixa de ter essa característica a partir do volume 19 de 2010. Essa mudança busca acompanhar o crescimento vertiginoso das solicitações de submissão dos últimos anos e ampliar as possibilidades de socialização da informação científica oriunda das diversas áreas da saúde e da Enfermagem. Não haverá mais uma restrição temática para que o conhecimento produzido em uma determinada área ou especialidade possa ser submetido para publicação e, quiçá aprovado para publicação, após a conclusão de todas as etapas, desde a avaliação por pares até a re-visão final do manuscrito." 3071 3996 W4248561575.pdf 0 22 separator 0.9960873 ¶ 3998 4000 W4248561575.pdf 0 23 paratext 0.7008005 Texto Contexto Enferm, Florianópolis, 2010 Jan-Mar; 19(1): 11-2. 4000 4065 W4248561575.pdf 0 0 table 0.9947229 "Tampa Bay 12,443 (100.0) 7,509 (60.4) 621 (5.0) 688 (5.5) 3,625 (29.1) Central Florida 14,000 (100.0) 8,255 (59.0) 842 (6.0) 727 (5.2) 4,176 (29.8) Northeast Florida 10,581 (100.0) 5,844 (55.2) 844 (8.0) 562 (5.3) 3,331 (31.5) Southwest Florida 8,644 (100.0) 5,203 (60.2) 602 (7.0) 546 (6.3) 2,293 (26.5) Northwest Rural 4,272 (100.0) 2,238 (52.4) 327 (7.7) 305 (7.1) 1,402 (32.8) Marital status <0.01 Not married 28,016 (100.0) 15,207 (54.3) 1,859 (6.6) 1,554 (5.6) 9,396 (33.5) Married 35,235 (100.0) 22,670 (64.3) 2,120 (6.0) 1,979 (5.6) 8,466 (24.0) Unknown 1,748 (100.0) 934 (53.4) 141 (8.1) 101 (5.8) 572 (32.7) AJCC stage SEER <0.01 Stage I 46,333 (100.0) 29,317 (63.3) 3,383 (7.3) 2,494 (5.4) 11,139 (24.0) Stage II 11,156 (100.0) 6,288 (56.4) 374 (3.4) 544 (4.9) 3,950 (35.4) Unknown 7,510 (100.0) 3,206 (42.7) 363 (4.8) 596 (7.9) 3,345 (44.5) Histology <0.01 Adenocarcinoma 35,265 (100.0) 25,139 (71.3) 1,750 (5.0) 1,939 (5.5) 6,437 (18.3) Squamous cell carcinoma 18,132 (100.0) 9,906 (54.6) 1,165 (6.4) 1,233 (6.8) 5,828 (32.1) Large cell carcinoma 1,220 (100.0) 792 (64.9) 28 (2.3) 39 (3.2) 361 (29.6) Unspecified and Others 4,177 (100.0) 306 (7.3) 529 (12.7) 99 (2.4) 3,243 (77.6) NSCLC NOS 5,499 (100.0) 2,194 (39.9) 631 (11.5) 293 (5.3) 2,381 (43.3) CCI <0.01 CCI=0 16,818 (100.0) 11,477 (68.2) 744 (4.4) 1,070 (6.4) 3,527 (21.0) 1 ≤ CCI ≤ 2 36,194 (100.0) 22,323 (61.7) 1,936 (5.4) 1,982 (5.5) 9,953 (27.5) CCI ≥ 3 7,780 (100.0) 3,942 (50.7) 558 (7.2) 577 (7.4) 2,703 (34.7) Cancer sequence number <0.01 One primary in the patient’s lifetime 36,316 (100.0) 20,843 (57.4) 2,060 (5.7) 1,528 (4.2) 11,885 (32.7) 1st of two or more primaries 7,211 (100.0) 5,100 (70.7) 382 (5.3) 445 (6.2) 1,284 (17.8) ≥2nd of two or more primaries 21,472 (100.0) 12,868 (59.9) 1,678 (7.8) 1,661 (7.7) 5,265 (24.5) Cancer sequence number † <0.01 One primary in the patient’s lifetime 36,316 (55.9) 20,843 (53.7) 2,060 (50.0) 1,528 (42.1) 11,885 (64.5) 1st of two or more primaries 7,211 (11.1) 5,100 (13.1) 382 (9.3) 445 (12.3) 1,284 (7.0) ≥2nd of two or more primaries 21,472 (33.0) 12,868 (33.2) 1,678 (40.7) 1,661 (45.7) 5,265 (28.6)" 0 2440 W4393863549.pdf 1 1 separator 0.527639 2443 2444 W4393863549.pdf 1 2 table 0.9436412 "¶ Abbreviations: SD, standard deviation; AJCC, American Joint Committee on Cancer; CCI, Charlson Comorbidity Index; NSCLC, non -small cell lung cancer; NOS: not otherwise specified; SBRT , stereotactic body radiation therapy." 2444 2672 W4393863549.pdf 1 3 separator 0.91087735 ¶ 2674 2676 W4393863549.pdf 1 4 table 0.80496365 * P-value obtained from chi -square test. 2676 2721 W4393863549.pdf 1 5 text 0.34318322 ¶ 2721 2722 W4393863549.pdf 1 6 table 0.762925 † Column percentage. 2722 2743 W4393863549.pdf 1 7 separator 0.9940928 ¶ 2745 2747 W4393863549.pdf 1 0 paratext 0.9627695 "12 Vol:.(1234567890) Scientific Reports | (2021) 11:3534 | https://doi.org/10.1038/s41598-021-83009-2" 0 113 W3128886743.pdf 11 1 separator 0.732216 113 114 W3128886743.pdf 11 2 paratext 0.90263695 ¶ www.nature.com/scientificreports/Reprints and permissions information is available at www.nature.com/reprints. 114 226 W3128886743.pdf 11 3 separator 0.98422015 ¶ 226 228 W3128886743.pdf 11 4 title 0.5684125 Publisher’s note 228 245 W3128886743.pdf 11 5 text 0.7273846 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 245 367 W3128886743.pdf 11 6 separator 0.9802259 ¶ 367 369 W3128886743.pdf 11 7 paratext 0.8780463 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/." 369 1249 W3128886743.pdf 11 8 separator 0.97933507 ¶ 1249 1251 W3128886743.pdf 11 9 paratext 0.7131469 © 1251 1253 W3128886743.pdf 11 10 title 0.47284937 The Author(s) 1253 1267 W3128886743.pdf 11 11 paratext 0.75967675 2021 1267 1272 W3128886743.pdf 11 12 separator 0.96454096 ¶ ¶ 1272 1278 W3128886743.pdf 11 13 title 0.50323623 COLOR Study Group 1278 1296 W3128886743.pdf 11 14 separator 0.8902119 ¶ 1296 1298 W3128886743.pdf 11 15 table 0.71785647 "Anundorn Wongteerasut1, Kaouther Ben‐Amor2, Rocio Martin2, Steven Ting3, Orapa Suteerojntrakool4, Chonikarn Visuthranukul4 & Punnapatch Piriyanon5" 1298 1448 W3128886743.pdf 11 0 text 0.99463606 "among firms. ”He lists as characteristics of an alliance the voluntariness, fixation by agreement, exchange and/or pooling of resources and the sharing of bene fit and control." 0 177 W3008176063.pdf 5 1 separator 0.9825877 ¶ 177 179 W3008176063.pdf 5 2 text 0.9985954 "A more restricted view by Yoshino and Rangan ( 1995 ,p .4 –5) defines“a strategic alliance as possessing simultaneously the following three necessary and suf ficient characteristics ”: Two or more firms remain independent, share bene fits and control and“contribute to a continuing basis in one or more key strategic areas ”." 179 507 W3008176063.pdf 5 3 separator 0.9464475 ¶ 507 509 W3008176063.pdf 5 4 text 0.99894094 "Suen ( 2005 ) combines this de finition with the speci fics by Gomes-Casseres (1999 , p. 34): Each partner has only limited control and the cooperation is based on“an incomplete contract ”.“Because the partners remain separate firms, there is no automatic convergence in their interest and actions. As a result, to deal with unforeseen contingencies the partners need to make decisions jointly. ”" 509 911 W3008176063.pdf 5 5 separator 0.9881832 ¶ 911 913 W3008176063.pdf 5 6 text 0.9990257 "DePamphilis ( 2018 , p. 553) uses the overall term of “Business Alliances ”which covers a variety of partnerships (Joint Venture, Strategic Alliances, Equity Partner-ships, Licensing, Franchising, Network Alliances, Exclusive Agreements) withdifferent characteristics but “the common goal of the partners are the sharing of risks, rewards and control ”." 913 1271 W3008176063.pdf 5 7 separator 0.9862125 ¶ 1271 1273 W3008176063.pdf 5 8 text 0.99205357 "The Association of Strategic Alliance Professionals (ASAP) says about the motivation for partnering: “Typically, strategic alliances have a broad and long- term impact on corporate performance and valuation. Often, strategic alliances are formed to create a competitive advantage for the partners in their respective markets ” (https://www.strategic-alliances.org/page/alliance_de finitions )." 1273 1674 W3008176063.pdf 5 9 separator 0.9907572 ¶ 1674 1676 W3008176063.pdf 5 10 text 0.993877 "Merger and Acquisitions (M&A) activities are closely related to alliances and often seen as a kind of de finitive, non-temporary alliance with a high level of control. The main differences are a higher investment, interest of controlling, less flexibility and the joint organizations become either one or belong to the same corporate parent(Gomes et al. 2011 , p. 7f.)." 1676 2050 W3008176063.pdf 5 11 separator 0.9912838 ¶ 2050 2052 W3008176063.pdf 5 12 text 0.9525767 "The range of strategic alliances from pure contractual, non-equity based alliances like market transactions to equity-based alliances with its most de finitive form of an acquisition is shown in Fig. 2." 2052 2258 W3008176063.pdf 5 13 separator 0.98475707 ¶ 2258 2260 W3008176063.pdf 5 14 text 0.9782136 "There are three main types of alliances which can be assigned to the three main stages of the pharmaceutical value chain as shown in Fig." 2260 2400 W3008176063.pdf 5 15 separator 0.9802583 ¶ 2400 2402 W3008176063.pdf 5 16 bibliography 0.98399305 1. Austin ( 2008 , p. 166) 2402 2429 W3008176063.pdf 5 17 separator 0.9564189 ¶ 2429 2431 W3008176063.pdf 5 18 text 0.6179568 "differentiates accordingly: Research alliances" 2431 2481 W3008176063.pdf 5 19 table 0.498199 for discovery 2481 2495 W3008176063.pdf 5 20 text 0.52365804 , target and lead 2495 2512 W3008176063.pdf 5 21 table 0.54516524 molecule 2512 2521 W3008176063.pdf 5 22 text 0.5120154 identi fication, 2521 2537 W3008176063.pdf 5 23 table 0.4995277 for 2537 2542 W3008176063.pdf 5 24 text 0.55140203 ¶ assays, mechanisms etc. 2542 2567 W3008176063.pdf 5 25 separator 0.7989737 ¶ 2567 2569 W3008176063.pdf 5 26 table 0.9757077 "Market transactionsAcquisitionsR&D contractCo- marketingStrategic Partner*Licensing/ Franchising Cross- share- holdingStrategic investmentJoint ventureInformal collaborationContractual/Non-equity-based alliances Equity-based alliances" 2569 2829 W3008176063.pdf 5 27 separator 0.9777077 ¶ 2829 2831 W3008176063.pdf 5 28 caption 0.994018 "Fig. 2 Range of alliances from market transactions to acquisitions. Adapted from (Peng 2014 , p. 213) and (Herrmann and Dressel 2014 ). *E.g. strategic supplier, distributor, service provider68 E. Hörner" 2831 3037 W3008176063.pdf 5 0 paratext 0.9901919 Atmosphere 2023 ,14, 222 8 of 18 0 32 W4317930155.pdf 7 1 separator 0.80736977 ¶ 32 34 W4317930155.pdf 7 2 paratext 0.9838418 Atmosphere 2023 , 14, x FOR PEER REVIEW 10 of 21 34 83 W4317930155.pdf 7 3 separator 0.96374613 "¶ ¶" 84 94 W4317930155.pdf 7 4 caption 0.9963763 "Figure 6. Observations of CD on 28 February 2009 showing the AU/AL (auroral upper/auroral lower) indices, the magnetic field components in GSM coordinates at P4 and P5, current densities in the layer embedded by P4 and P5, power within the layer, and the average electric field at the two satellites at CD." 94 405 W4317930155.pdf 7 5 separator 0.9947494 ¶ 405 407 W4317930155.pdf 7 6 text 0.9959696 "The second last panel of Figure 6 shows the dissipation parameters in both x- and y-directions using different colors. The last panel shows the average electric field of the two satellites, also in both x- and y-directions using different colors. Note that since the power dissipation is mainly caused by the electric field, the role of CCI in power dissipation during a substorm is the rapid magnetic field changes as a result of current changes caused by the CCI." 407 881 W4317930155.pdf 7 0 paratext 0.990325 J. Clin. Med. 2021 ,10, 3185 2 of 15 0 36 W3185159463.pdf 1 1 separator 0.9749646 ¶ 36 38 W3185159463.pdf 1 2 text 0.99968934 "in increased endothelial permeability, consequently enabling the infiltration of various lipids such as low-density lipoprotein (LDL) into the intima. Here, LDL can be modified into oxidized LDL (oxLDL) by reactive oxygen species (ROS), which are released by the damaged endothelial cells (ECs) [ 4,5]. Both the accumulation of lipids and the endothe- lial damage trigger an inflammatory reaction, which includes the release of chemokines from the activated endothelium and the expression of adhesion molecules on ECs [ 4,5]." 38 571 W3185159463.pdf 1 3 separator 0.8757887 ¶ 571 573 W3185159463.pdf 1 4 text 0.99974245 "This inflammatory response stimulates the recruitment and adhesion of leukocytes, pre- dominantly monocytes, to the endothelium [ 6]. Subsequently, these immune cells will transmigrate into the vessel wall, a process that is also guided by chemokines and adhesion molecules. The infiltrated monocytes will differentiate into macrophages, which take up oxLDL and cell debris, leading to the formation of foam cells [ 7,8]. Foam cells on their turn release inflammatory cytokines, which again triggers the recruitment cascade, thereby creating a vicious cycle. The continued recruitment of monocytes into the vessel wall results in the formation and further development of so called fatty-streak lesions. During lesion development, medial vascular smooth muscle cells (vSMCs) migrate towards the luminal side of the lesion where they produce collagen, which consequently leads to the formation of a fibrotic cap on top the macrophage rich areas of the plaque. In this stage, macrophages residing inside the lesion will not only secrete inflammatory cytokines, but also matrix metalloproteinases (MMPs), which break down extracellular matrix compo- nents in the plaque cap, thereby destabilizing the plaque. Moreover, due to continued lipid accumulation these macrophages become apoptotic, contributing to the formation of the necrotic core and thereby mediating plaque progression into an advanced stage [ 9]." 573 2006 W3185159463.pdf 1 5 separator 0.95167804 ¶ 2006 2008 W3185159463.pdf 1 6 text 0.9997736 "Furthermore, in advanced human lesions angiogenesis plays an important role driven by macrophages [ 10,11]. Eventually, the continued growth of the plaque together with the thinning of the fibrotic cap can lead to plaque rupture and thrombus formation. The thrombus can then trigger other cardiovascular events, such as MI or stroke by occluding certain vessels in the heart or the brain, respectively [8]." 2008 2422 W3185159463.pdf 1 7 separator 0.9964814 ¶ 2422 2424 W3185159463.pdf 1 8 title 0.9940349 1.2. Current CVD-Therapies 2424 2451 W3185159463.pdf 1 9 separator 0.9957723 ¶ 2451 2453 W3185159463.pdf 1 10 text 0.99975824 "CVD management mainly revolves around the stabilization of blood lipid levels via statins and the reduction of thrombotic factors via for example aspirin, which result in slowing down disease progression. Statins are the current gold standard of CVD- therapy. They inhibit HMG-CoA reductase, consequently decreasing the production of cholesterol [ 12]. A meta-analysis on clinical statin trials unveiled that this medication can indeed reduce the LDL levels in plasma by 50–55% thereby also significantly decreasing the risk of further cardiovascular events [ 13]. However, treatment with statins also has a lot of off-target effects. For example, a study by Preiss et al. [ 14] revealed that treatment with statins increased the risk for the development of diabetes by a striking 9%. This discovery led to a discussion about the use of statins in the clinic and especially stimulated the development of alternative treatment options. One of these new strategies is the use of monoclonal antibodies against proprotein convertase subtilisin/kexin type 9 (PCSK9)." 2453 3536 W3185159463.pdf 1 11 separator 0.9848887 ¶ 3536 3538 W3185159463.pdf 1 12 text 0.99972236 "Its physiological function is to stimulate the degradation of the LDL receptor via direct interaction in the liver [ 15]. Additionally, PCSK9 prevents LDL receptor recycling to the membrane. In this way, inhibiting PCSK9 will avert LDL receptor degradation and hence lead to increased surface expression of LDL receptors that can bind and internalize LDL particles, thereby lowering plasma LDL levels. Interestingly, PCSK9 inhibition can reduce plasma LDL levels by a striking 60%, even on top of statin-induced LDL decrease, without any signs of serious side effects [ 16–18]. Although PCSK9 inhibition is a very promising therapeutic option, the production costs of these antibodies remain at the moment too high in order for it to be used on a large scale." 3538 4314 W3185159463.pdf 1 13 separator 0.98461175 ¶ 4314 4316 W3185159463.pdf 1 14 text 0.99972194 "Besides these lipid-focused CVD-therapies, novel methods based on immunomod- ulation have emerged in the last decades. The immune system protects the body from infections. In large parts, this is based on the recognition of “self” and “non-self”. Im- munity is vital to protect the body, but exaggerated inflammation and elevated white" 4316 4657 W3185159463.pdf 1 0 paratext 0.9405041 "International Journal of Current Advanced Research ¶ Vol 6 , Issue 03 , pp 2496 - 2499 , March ¶ 201 7 ¶ ¶ 2499 ¶" 0 155 W2610202791.pdf 3 1 separator 0.5104096 ¶ 157 159 W2610202791.pdf 3 2 bibliography 0.98026854 "13. ¶ Son EJ, Oh KK, Kim ¶ EK. Pregnancy associated breast disease: Radiologic features and diagnostic dilemmas. Yonsei Med J. 2006 Feb 28; 47(1): 34 - 42. ¶ 14. ¶ Sawhney S et al .Ultrasound separates galactoceles from simple cysts. Ultrasound reviews; 2002 Apr " 159 460 W2610202791.pdf 3 3 separator 0.61664987 ¶ 460 461 W2610202791.pdf 3 4 bibliography 0.50971156 9. 461 464 W2610202791.pdf 3 5 paratext 0.5960018 "Available from: http://www.au ntminnie.com/ index" 464 518 W2610202791.pdf 3 6 bibliography 0.5209951 . 518 519 W2610202791.pdf 3 7 paratext 0.6232528 "¶ aspx?sec=ser&sub=def&pag=dis&ItemID=53045 ." 520 568 W2610202791.pdf 3 8 separator 0.48124766 568 569 W2610202791.pdf 3 9 paratext 0.48394042 ¶ 569 570 W2610202791.pdf 3 10 separator 0.4909284 ¶ 572 574 W2610202791.pdf 3 11 bibliography 0.97174776 "15. ¶ Nikumbh DB, Desai SR, Shrigondekar PA et al . Crystallizing galactocele – An Unusual diagnosis on Fine needle Aspiration cytology. J Clin Diagn Res . 2013; 7(3): 604 -" 574 777 W2610202791.pdf 3 12 separator 0.74308467 ¶ 777 779 W2610202791.pdf 3 13 bibliography 0.4285282 5. 779 782 W2610202791.pdf 3 14 table 0.5710478 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 782 984 W2610202791.pdf 3 15 separator 0.30002615 986 987 W2610202791.pdf 3 16 table 0.2599552 ¶ 987 988 W2610202791.pdf 3 17 separator 0.54904234 ¶ ¶ 990 996 W2610202791.pdf 3 18 bibliography 0.98095304 "16. ¶ Rosen, Peter P, editors. Rosen’s Breast Pathology. 3 rd ¶ edition. Lippincot Williams and Wilkins ; 2009. P. 34 - 70. ¶ 17. ¶ Jyothi K, Baliga V. Crystallizing Galactocele - A Cytological Dilemma: Case Report. Sch J App Med ¶ Sci.2015; 3(1B):129 - 30. ¶ 18. ¶ Nuzhat S, Qayoom S, Zubair Q et al . Old Crystallizing Galactocele - ¶ A Rare Case Report. J Cytol Histol . 2015; 6: 325 - 6. ¶ 19. ¶ Shetty A, Narasimha A, Jayalakshmi VJ. Crystallising Galactocele: Report of a rare variation . Breast disease . 2016; 36(2 - 3): 111 - " 996 1643 W2610202791.pdf 3 19 separator 0.62047684 ¶ 1643 1644 W2610202791.pdf 3 20 bibliography 0.44445914 4. 1644 1647 W2610202791.pdf 3 21 table 0.4110674 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ " 1647 1756 W2610202791.pdf 3 22 math 0.2985605 ¶ 1756 1757 W2610202791.pdf 3 23 table 0.28953132 1759 1760 W2610202791.pdf 3 24 math 0.32260516 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 1760 1925 W2610202791.pdf 3 25 table 0.29374227 1927 1928 W2610202791.pdf 3 26 math 0.32272485 ¶ 1928 1929 W2610202791.pdf 3 27 table 0.29665753 1931 1932 W2610202791.pdf 3 28 math 0.32082638 ¶ 1932 1933 W2610202791.pdf 3 29 table 0.29988706 1935 1936 W2610202791.pdf 3 30 math 0.3184211 ¶ 1936 1937 W2610202791.pdf 3 31 table 0.30333072 1939 1940 W2610202791.pdf 3 32 math 0.31640303 ¶ 1940 1941 W2610202791.pdf 3 33 table 0.30622885 1943 1944 W2610202791.pdf 3 34 math 0.31447583 ¶ 1944 1945 W2610202791.pdf 3 35 table 0.3095444 1947 1948 W2610202791.pdf 3 36 math 0.3119564 ¶ 1948 1949 W2610202791.pdf 3 37 table 0.3176523 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 1951 2013 W2610202791.pdf 3 38 separator 0.27653316 2015 2016 W2610202791.pdf 3 39 math 0.21576013 ¶ 2016 2017 W2610202791.pdf 3 40 separator 0.59333485 "¶ ¶" 2019 2029 W2610202791.pdf 3 41 paratext 0.7656571 "How to cite this article: ¶ R" 2029 2068 W2610202791.pdf 3 42 contact 0.36588642 adhika 2068 2074 W2610202791.pdf 3 43 paratext 0.51992077 Ya 2074 2077 W2610202791.pdf 3 44 contact 0.46233866 jaman 2077 2082 W2610202791.pdf 3 45 paratext 0.5065657 Gurumurthy and Na 2082 2100 W2610202791.pdf 3 46 contact 0.41641554 dig 2100 2103 W2610202791.pdf 3 47 paratext 0.47120038 Sidd 2103 2108 W2610202791.pdf 3 48 bibliography 0.33013558 harth 2108 2113 W2610202791.pdf 3 49 paratext 0.55339944 "Shankar ¶ (2017)" 2113 2134 W2610202791.pdf 3 50 separator 0.5178334 ¶ 2135 2137 W2610202791.pdf 3 51 paratext 0.57570076 "' ¶ Crystall" 2137 2154 W2610202791.pdf 3 52 bibliography 0.3895397 izing 2154 2159 W2610202791.pdf 3 53 paratext 0.4954399 Ga 2159 2162 W2610202791.pdf 3 54 bibliography 0.39760154 lactocele ¶ 2162 2174 W2610202791.pdf 3 55 paratext 0.44464535 2174 2175 W2610202791.pdf 3 56 bibliography 0.48483014 "- ¶ Histopathological Diagnosis Of An Enigmatic Entity" 2175 2236 W2610202791.pdf 3 57 separator 0.4184469 ¶ 2236 2238 W2610202791.pdf 3 58 bibliography 0.36951098 ¶ 2240 2242 W2610202791.pdf 3 59 paratext 0.53614557 ' 2242 2244 W2610202791.pdf 3 60 separator 0.361476 ¶ 2244 2246 W2610202791.pdf 3 61 paratext 0.67262316 , 2246 2248 W2610202791.pdf 3 62 separator 0.6168324 ¶ 2249 2251 W2610202791.pdf 3 63 paratext 0.9523583 "International Journal of Current Advanced Research, 06(03), pp. 2496 - 2499 . ¶ DOI: ¶ ht tp://dx.doi.org/10.24327/ijcar.2017. 2499 .0036 ¶ *******" 2251 2433 W2610202791.pdf 3 64 separator 0.9757208 ¶ 2433 2435 W2610202791.pdf 3 0 math 0.796616 "qt tf=+.0(2)" 0 14 W2899385742.pdf 6 1 separator 0.9936626 ¶ 14 16 W2899385742.pdf 6 2 text 0.99930847 "The feature that if δR.11" 16 558 W2899385742.pdf 6 3 separator 0.9901018 ¶ 558 560 W2899385742.pdf 6 4 text 0.9983229 "Keeping in mind the “classical results ”from for example, Becker ( 1968 ) and Allingham and Sandmo ( 1972 ), Proposition 1(ii) may appear counterintuitive. The cost to the taxpayer of getting caught, f, has no effect on the evasion probability, but on the authority's audit prob- ability. While this effect is not the usual in the tax ‐compliance literature, where the taxpayer is regarded as the only active part, it is a typical finding for inspection games as presented, for example, in Graetz et al. ( 1986 ).12When inspector and inspectee move simultaneously, the unique and mixed equilibrium implies that the two players, so to say, hold each other in- different. Since a more severe punishment makes evasion less attractive, the inspection prob- ability has to go down in order for the taxpayer to remain indifferent between evading anddeclaring. The effects of harsher punishment are manifested, not in terms of less crime, butrather in terms of less inspection." 560 1547 W2899385742.pdf 6 5 separator 0.9690522 ¶ 1547 1549 W2899385742.pdf 6 6 text 0.9965151 "Note that we have not mentioned player 3 at all. Rightly so, since 3 has no bearing on anything under classical preferences." 1549 1676 W2899385742.pdf 6 7 separator 0.9966129 ¶ 1676 1678 W2899385742.pdf 6 8 title 0.99145234 3|INCORPORATING GUILT 1678 1700 W2899385742.pdf 6 9 separator 0.9964745 ¶ 1700 1702 W2899385742.pdf 6 10 text 0.99913543 "The filing of tax returns is an example where guilt plausibly influences behavior. By with- holding provision of public funds, tax evaders may hurt fellow citizens who expect compliance.Conscientious filers dislike that and may declare honestly to avoid guilt. This is in line withfindings in psychology. In an influential study, (Baumeister et al., 1994 , p. 247) explain that ""If people feel guilt for hurting their partners ...and for failing to live up to their expectations, they will alter their behavior (to avoid guilt) in ways that seem likely to maintain and strengthen therelationship. ”" 1702 2305 W2899385742.pdf 6 11 separator 0.91580904 ¶ 2305 2307 W2899385742.pdf 6 12 text 0.9853747 "13Note the link to others' expectations. Using designs that elicit beliefs about beliefs, several experimental studies tested for such belief ‐dependent motivation and found support.14B&D develop two models —simple guilt and guilt from blame —that describe how" 2307 2572 W2899385742.pdf 6 13 separator 0.69302535 ¶ 2572 2574 W2899385742.pdf 6 14 paratext 0.72860736 11 2574 2577 W2899385742.pdf 6 15 separator 0.9824513 ¶ 2577 2579 W2899385742.pdf 6 16 text 0.77672136 IfδR=, then equilibrium requires 2579 2612 W2899385742.pdf 6 17 math 0.82115996 "p=00and  q ,1t tf0 +∈ ." 2612 2664 W2899385742.pdf 6 18 separator 0.96802306 ¶ 2664 2666 W2899385742.pdf 6 19 text 0.9477175 "12The broader and somewhat counterintuitive game ‐theoretic angle is that as regards mixed strategy equilibrium a change in one player's payoff is predicted to only affect the other player's behavior." 2666 2869 W2899385742.pdf 6 20 bibliography 0.62285465 Camer 2869 2875 W2899385742.pdf 6 21 text 0.49776998 er 2875 2877 W2899385742.pdf 6 22 bibliography 0.81360584 ( 2003 , pp. 139 –140) 2877 2900 W2899385742.pdf 6 23 text 0.79206437 ¶ discusses lab experiments that tested this prediction and reports that 2900 2973 W2899385742.pdf 6 24 bibliography 0.6071774 “This 2973 2979 W2899385742.pdf 6 25 text 0.8099988 "wacky prediction is surprisingly close to correct. " 2979 3033 W2899385742.pdf 6 26 bibliography 0.5502016 ” 3033 3034 W2899385742.pdf 6 27 text 0.9416491 "We also note that there is large experimental literature on ‐œtax evasion games ‐Âİwhich largely does not shed light on the issue discussed here since most of the games studied are not inspection games but rather treat theinspection probability as a parameter; see Alm and Malézieux ( 2021 , especially" 3034 3338 W2899385742.pdf 6 28 bibliography 0.53566545 p. 713 3338 3345 W2899385742.pdf 6 29 text 0.59649765 ). 3345 3347 W2899385742.pdf 6 30 separator 0.91131634 ¶ 3347 3349 W2899385742.pdf 6 31 bibliography 0.9630134 13Compare also Baumeister et al. ( 1995 ) and Tangney ( 1995 ). 3349 3413 W2899385742.pdf 6 32 separator 0.9635236 ¶ 3413 3415 W2899385742.pdf 6 33 bibliography 0.9442074 "14For example, Dufwenberg and Gneezy ( 2000 ) show for a dictator game that more is given by subjects who expect their co‐players to expect a lot. See also Dufwenberg and studies have met some criticism —see Ellingsen et al. ( 2010 ) and Vanberg ( 2008 )—and some follow ‐up defense —see for example, Khalmetski et al. ( 2015 ). Cartwright ( 2019 ) surveys much of the literature.DUFWENBERG ANDNORDBLOM" 3415 3824 W2899385742.pdf 6 34 paratext 0.9540388 | 11 3824 3829 W2899385742.pdf 6 0 paratext 0.9429844 "Devina Rizka Fajriati dkk, Abdi Implementasi Pancasila: Jurnal Pengabdian Masyarakat , Volume ; 3 Nomor: 1 Nomor Halaman 11-15 DOI: ¶ 14" 0 151 W4378803631.pdf 3 1 text 0.80545104 "Sebelum adanya kegiatan penyuluhan pembuatan jamu instan ol" 152 215 W4378803631.pdf 3 2 title 0.63315505 eh 215 218 W4378803631.pdf 3 3 text 0.9941069 "kelompok KKM UIN Malang, ternyata masih banyak masyarakat Desa Bayem yang belum mengetahui bagaimana proses pembuatan jamu beras kencur menjadi serbuk. Hal ini membuat masyarakat desa tertarik dan antusias dalam mengikuti kegiatan penyuluhan ini. Kegiat an penyuluhan dimulai dengan membahas apa itu obat tradisional dan ‘TOGA’. Menurut BPOM (2014), obat tradisional adalah bahan atau ramuan yang berupa tumbuhan, hewan, mineral, sediaan sarian (galenik) atau campuran dari salah satu bahan tersebut yang secar a turun temurun telah digunakan untuk pengobatan, dan dapat diterapkan sesuai dengan norma yang berlaku di masyarakat. Di Indonesia, obat herbal yang merupakan bagian dari obat bahan alam dapat dikelompokkan menjadi 3 kelompok yaitu jamu, obat herbal terstandar, dan fitofarmaka (Oktaviani et al , 2020). Sementara itu, ‘TOGA’ (Tanaman Obat Keluarga) merupakan beberapa jenis tanaman obat pilihan yang dapat ditanam di pekarangan ataupun lingkungan rumah. Biasanya, tanaman obat yang dipilih adalah tanaman yang digunakan untuk pengobatan pada penyakit ringan seperti demam, batuk, dan pilek." 218 1400 W4378803631.pdf 3 4 separator 0.96758664 ¶ 1401 1403 W4378803631.pdf 3 5 text 0.99857193 "Keberadaan TOGA di lingkungan rumah cukup penting terutama bagi keluarga atau masyarakat yang memiliki akses cukup sulit ke pelayananan medis atau fasilitas kesehatan (Puspitas ari et al , 2021). Salah satu tanaman obat keluarga yang dapat dimanfaatkan dan ditanam masyarakat Desa Bayem adalah kencur." 1403 1726 W4378803631.pdf 3 6 separator 0.9915576 ¶ 1728 1730 W4378803631.pdf 3 7 text 0.9983381 "Bahan -bahan yang diperlukan dalam kegiatan penyuluhan pembuatan jamu serbuk ini antara lain adalah simplisia basah kencur, serai dap ur, kayu manis, tepung beras, gula putih, garam, dan air. Sedangkan, peralatan yang digunakan antara lain adalah kompor, wajan, sutel (spatula), tumbukan kayu, gelas ukur, saringan, dan timbangan. Pada dasarnya, bahan dan alat yang digunakan untuk membuat jamu instan beras kencur ini sederhana dan mudah didapatkan" 1730 2207 W4378803631.pdf 3 8 separator 0.99189734 ¶ 2210 2212 W4378803631.pdf 3 9 text 0.9921667 "Proses pembuatan jamu beras kencur diawali dengan menyiapkan simplisia basah kencur terlebih dahulu. Kencur yang sudah dikupas dan dicuci bersih selanjutnya ditumbuk hingga halus, kemudian ditamb ahkan air. Setelah ditambahkan air, kencur diperas dan diendapkan selama 30 menit. Tujuan pengendapan air perasan kencur ini adalah untuk memisahkan antara air dan sari pati dari kencur itu sendiri. Pemisahan ini dilakukan dengan maksud agar memudahkan pro ses pengkristalan jamu untuk menjadi serbuk nantinya." 2212 2755 W4378803631.pdf 3 10 separator 0.894297 ¶ 2757 2759 W4378803631.pdf 3 11 text 0.9991305 "Setelah proses pengendapan selesai, air hasil endapan dipisahkan dari sari patinya dan diaduk terus menerus di dalam wajan sampai berubah menjadi serbuk. Dalam proses pengadukkan, secara perlahan ditamb ahkan serai dapur dan juga kayu manis. Apabila sudah mendidih, tepung beras, gula pasir, dan garam dimasukkan. Seluruh rangkaian proses pembuatan serbuk jamu beras kencur ini memakan waktu selama kurang lebih tiga jam." 2759 3208 W4378803631.pdf 3 12 separator 0.990232 ¶ ¶ 3210 3216 W4378803631.pdf 3 13 caption 0.9924018 "Gambar 2. Demonstrasi Pembuatan Jam u Beras Kencur Instan" 3216 3277 W4378803631.pdf 3 14 separator 0.98939764 ¶ 3279 3281 W4378803631.pdf 3 15 text 0.9930593 "Kegiatan penyuluhan ini memberikan manfaat besar bagi masyarakat desa Bayem dalam memanfaatkan tanaman obat -obatan yang terdapat di sekitar menjadi jamu tradisional dengan kadar penyimpanan yang ¶" 3281 3492 W4378803631.pdf 3 0 paratext 0.9876844 Magnus Alm Rosenblad et al. / MycoKeys 13: 21–33 (2016)26 0 59 W2381190404.pdf 5 1 title 0.89387846 "Table 1. Data on the underlying specimens and PCR primers. The already sequenced specimens of Russula and Lactarius were re-sequenced with a different primer pair compared to the extant " 59 251 W2381190404.pdf 5 2 text 0.44648954 sequence 251 259 W2381190404.pdf 5 3 title 0.43955725 s. 259 261 W2381190404.pdf 5 4 text 0.7345184 "Our Philippines specimen of Astraeus sirindhorniae had never been sequenced before, but we used a different primer pair compared to the Astraeus sirindhorniae sequence generated by Phosri et al. (2014) from a Thailand collection. Primer" 261 505 W2381190404.pdf 5 5 title 0.35026228 505 506 W2381190404.pdf 5 6 text 0.35530093 sequence 506 514 W2381190404.pdf 5 7 table 0.3254387 s 514 515 W2381190404.pdf 5 8 text 0.35541978 are available 515 529 W2381190404.pdf 5 9 table 0.3611052 in Supp 529 537 W2381190404.pdf 5 10 title 0.41670817 l. 537 539 W2381190404.pdf 5 11 text 0.3471829 material 1B 539 551 W2381190404.pdf 5 12 table 0.37562826 . 551 552 W2381190404.pdf 5 13 separator 0.9876168 ¶ 552 554 W2381190404.pdf 5 14 table 0.9925973 "Species Original entryResequenced entrySpecimen Herbarium CountryOriginal primersResequencing primersITS1 5.8S ITS2 Astraeus sirindhorniae(not sequenced before) KU356730 MA-Fungi 47735 Madrid Phillipines(not sequenced before)ITS5 / ITS4 1–442 443–444 - Lactarius luridus UDB023551 (UNITE) KU356731 TU118993 Tartu Estonia ITS0F / LB-W ITS1F / ITS4b 1–482 483–640 641–896 Russula olivacea UDB016000 (UNITE) KU356732 TU101845 Tartu Estonia ITS0Ft / LB-W ITS1F / ITS4b 1–457 458–615 616–891" 554 1062 W2381190404.pdf 5 0 separator 0.97587115 ¶ 2 3 W4384921604.pdf 6 1 title 0.98523146 АКАДЕМІЧНІ ВІЗІЇ 5 22 W4384921604.pdf 6 2 separator 0.89597005 ¶ 23 25 W4384921604.pdf 6 3 title 0.599823 Випуск 20/ 25 37 W4384921604.pdf 6 4 paratext 0.47972086 2023 37 41 W4384921604.pdf 6 5 separator 0.975158 ¶ 43 45 W4384921604.pdf 6 6 text 0.9993901 "різних джерелах . Крім того , виконання завдань з побудови інфографіки розвиває креативне та логічне мислення . К р е а т и в н і с т ь , а б о к р е а т и в н е м и с л е н н я , ф о р м у є компетентність до генерування нестандартних рішень та ідей , а логічне мислення ‐ до розуміння взаємозв 'язків між складними системами . Важко уявити на сьогоднішній день компетентного лікаря у якого б не були розвинені критичне мислення , цифрова грамотність та креативність . З в а ж а ю ч и н а з а з н а ч е н і а р г у м е н т и , с т а є з р о з у м і л и м , наскільки важливо створювати умови для формування та розвитку н аведених умінь та навичок під час навчання майбутнього лікаря ." 45 775 W4384921604.pdf 6 7 separator 0.99142563 ¶ ¶ 776 782 W4384921604.pdf 6 8 title 0.98021984 Висновки 782 791 W4384921604.pdf 6 9 separator 0.995276 ¶ 792 794 W4384921604.pdf 6 10 text 0.9989275 "Н а ф о р м у в а н н я т а р о з в и т о к у з д о б у в а ч і в о с в і т и з а г а л ь н и х т а ф а х о вих компетентностей значний вплив має ефективна організація самості йної роботи . Одним з методів організації такої робо т и є вико нання за вдан ь зі с т во р енням відповіді на проблемне запитання у вигляді інфографіки , що було застосовано під час вивчення медичної біохімії в Національному медичному університеті імені О.О. Богомольця ." 794 1267 W4384921604.pdf 6 11 separator 0.9935443 ¶ 1269 1271 W4384921604.pdf 6 12 text 0.99733174 "В и к о р и с т а н н я т а к и х з а в д а н ь п і д ч а с о с в і т н ь о г о п р о ц е с у д о з в о л я є реалізувати принцип індивідуального підходу , стимулювати пізнавальний інтерес , розвивати креативність , самостійність , критичне та логічного мислення . Вагомим пріоритетом завдань по створенню інфографіки є їхня відповідність принципу академічної доброчесності . Кожна робота індивідуальна , б а г а т о ш а р о в а т а м о ж е м і с т и т и р і з н і складові елементи : г р а ф і к и , с х е м и , ілюстрації , к о л ь о р о в у г а м у , п о с л і д о в н і с т ь розміщення інформації тощо . Вагомою перевагою застосува ння інфографічних завдань є їх проста перевірка . З першого погляду стає зрозуміли м наскільки детально здобувач освіти опанував проблематику питання та зумів логічно поєднати необхідну інформацію . Для створення якісної інфографіки потрібно всебічно вивчити зм іст теми , приділити увагу логічному поєднанню інформації , підібрати візуалізаційний матеріал , персоніфікувати інфографіку , щоб в результаті отримати графічний об ’єкт, який буде інформативним та зрозумілим не тільки автору , а й і н ш и м у ч а с н и к а м о с в і т н ь о г о процесу . В і д т а к , можемо констатувати , що застосування завдань із створення інфографіки в самостійній роботі здобувачів освіти сприяє форму ванню важливих особистісних якостей , таких як гнучкість , тайм‐менеджмент , цифрова та медіаграмотність ." 1271 2831 W4384921604.pdf 6 13 separator 0.9947151 ¶ ¶ 2832 2838 W4384921604.pdf 6 14 title 0.97539276 Список використаних джерел 2838 2865 W4384921604.pdf 6 15 separator 0.98868155 ¶ 2866 2868 W4384921604.pdf 6 16 bibliography 0.9908033 "1. Карапетян А .О. Особливості навчання представників покоління Z у вищій школі . Наукові записки . С е р і я : П е д а г о г і ч н і н а у к и . 2020. В и п . 186. С. 115 ‐ 120. DOI: https://doi.org/10.36550/2415 ‐7988‐2020‐1‐186‐115‐120." 2868 3118 W4384921604.pdf 6 17 separator 0.9539298 ¶ 3119 3121 W4384921604.pdf 6 18 bibliography 0.99698114 "2. Соболь Н . Заклади вищої освіти і покоління Z. Взаємна трансформація . Збірник наукових праць Національної академії Державної прикордонної слу жби України ." 3121 3292 W4384921604.pdf 6 19 separator 0.57545406 3293 3294 W4384921604.pdf 6 20 bibliography 0.9892934 "¶ Серія : П е д а г о г і ч н і н а у к и . 2021. No 4 (27). C. 188 ‐ 201. DOI: https://doi.org/10.32453/pedzbirnyk.v27i4.919 ." 3294 3426 W4384921604.pdf 6 21 separator 0.96264374 ¶ 3427 3429 W4384921604.pdf 6 22 bibliography 0.99726135 "3. Ломоносова О .Е. Адаптація університетів до особ ливостей підготовки студентів покоління Z д л я п р и й д е ш н ь о ї е к о н о м і к и з н а н ь . Причорноморські економічні студії . 2020. Вип . 56. С. 7 ‐ 15. URL: http://eir.nuos.edu.ua/handle/123456789/6023 ." 3429 3707 W4384921604.pdf 6 23 separator 0.9323802 ¶ 3708 3710 W4384921604.pdf 6 24 bibliography 0.9930117 "4. Шиян А ., Войтович О .М. Оцінка ефективності форм візуалізації навчального матеріалу в курсі “Природничі науки ”. Альманах науки . 2021. No 5 (50), С. 24 ‐ 29. URL: http://almanah.ltd.ua/save/2021/5%20%2850%29/5.pdf ." 3710 3945 W4384921604.pdf 6 25 separator 0.9322522 ¶ 3946 3948 W4384921604.pdf 6 26 bibliography 0.99708515 "5. Дегтярьова Г . Візуалізація як важливий засіб ефективної комунікації в процес і навчання . Соціальні комунікації : Теорія і практика . 2020. 1 (10). С. 93 ‐ 110. URL: https://new.comteka.com.ua/index. php/journal/article/view/36/21 ." 3948 4191 W4384921604.pdf 6 0 paratext 0.98886365 Molecules 2018 ,23, 2943 6 of 14 0 32 W2900439350.pdf 5 1 separator 0.9910272 ¶ 32 34 W2900439350.pdf 5 2 title 0.99076843 Table 4. Therapeutic index of synthetic peptides. 34 84 W2900439350.pdf 5 3 separator 0.99000263 ¶ 84 86 W2900439350.pdf 5 4 table 0.9947838 "Analog IdentificationMIC (M)MHC (M)Therapeutic Index (TI) E. coli S. aureus E. coli S. aureus P1-Ll-1577 20 40.5 640 32 15.8 P2-Ll-1298 24.6 49 320 13 6.5 P3-Ll-2085 15 15 40 2.7 2.7 MHC: minimal hemolytic concentration, MIC: minimal inhibitory concentration." 86 365 W2900439350.pdf 5 5 separator 0.9948621 ¶ 365 367 W2900439350.pdf 5 6 title 0.99404544 2.5. Secondary Structure Determination by Circular Dichroism (CD) 367 433 W2900439350.pdf 5 7 separator 0.99459964 ¶ 433 435 W2900439350.pdf 5 8 text 0.9992679 "The CD spectra of the analogs are shown in Figure 4. Spectra were collected in four distinct environments: water, trifluoroethanol (TFE)/water (50% v/v), and in the presence of DPPG or DPPC vesicles." 435 638 W2900439350.pdf 5 9 separator 0.99171144 ¶ 638 640 W2900439350.pdf 5 10 paratext 0.9877042 Molecules 2018 , 23, x 6 of 14 640 671 W2900439350.pdf 5 11 separator 0.9936477 ¶ 672 674 W2900439350.pdf 5 12 text 0.99966127 "All the analogs showed a therapeutic index ( TI) over 1 (Table 4 ), meaning that total hemolysis is not achieved at the MIC . P1-Ll-1577 showed exciting TI values, especially for E. coli . The lowest TI value was obtained with P3 -Ll-2085, comparable with that of toxins such as melitin, for which TI values of 0.6 against Gram (+) and Gram ( −) bacteria have been reported [35]." 674 1067 W2900439350.pdf 5 13 separator 0.9969139 ¶ 1068 1070 W2900439350.pdf 5 14 title 0.98721856 Table 4. Therapeutic index of synthetic peptides. 1070 1120 W2900439350.pdf 5 15 separator 0.9861022 ¶ 1122 1124 W2900439350.pdf 5 16 table 0.9945145 "Analog Identification MIC (μM) MHC (μM) Therapeutic Index (TI) E. coli S. aureus E. coli S. aureus P1-Ll-1577 20 40.5 640 32 15.8 P2-Ll-1298 24.6 49 320 13 6.5 P3-Ll-2085 15 15 40 2.7 2.7 MHC: minimal hemolytic concentration, MIC: minimal inhibitory concentration ." 1124 1427 W2900439350.pdf 5 17 separator 0.9954624 ¶ 1428 1430 W2900439350.pdf 5 18 title 0.9944115 2.5. Secondary Structure Determination by Circular Dichroism (CD) 1430 1496 W2900439350.pdf 5 19 separator 0.9952564 ¶ 1498 1500 W2900439350.pdf 5 20 text 0.99924767 "The CD spectra of the analogs are sho wn in Figure 4. Spectra were collected in four distinct environments: water, trif luoro ethanol (TFE)/water (50% v/v), and in the presence of DPPG or DPPC vesicles." 1500 1714 W2900439350.pdf 5 21 separator 0.98142046 ¶ ¶ 1716 1722 W2900439350.pdf 5 22 caption 0.9769343 "Figure 4. Circular dichroism spectra of synthetic analogs. (A) water, (B) TFE/ H2O (50%, v/v) (C) DPPG, (D) DPPC. Peptide concentration: 0.2 mg /mL." 1722 1875 W2900439350.pdf 5 23 separator 0.98334634 ¶ 1877 1879 W2900439350.pdf 5 24 text 0.9993949 "The CD spectra show ed that none of the compounds adopt ed a preferential conformation in water , which is consistent with the presence of a minimum at 198 nm. In the presence of TFE, P3 -Ll- 2085 adopt ed a helical conformation, an observation consistent with the presence of two minimums at 205–207 nm and 215 –220 nm and a maximum at 195 nm." 1879 2235 W2900439350.pdf 5 25 separator 0.92688406 ¶ 2237 2239 W2900439350.pdf 5 26 text 0.9996806 "Deconvolution spectra by SELCON and CONTILL methods indicated more than 70% helical structure for P3 -Ll-2085. P2 -Ll-1298 also showed contributions of α -helix, while P1 -Ll-1577, although present ing contributions of turn structure, was less order ed in the presence of TFE (percentage of an unordered structure high er than 40%)." 2239 2582 W2900439350.pdf 5 27 separator 0.9195156 ¶ 2584 2586 W2900439350.pdf 5 28 text 0.9996668 "In the presence of DPPG vesicles (Figure 4C), P3-Ll-2085 and P2 -Ll-1298 adopt ed a helical structure. Nevertheless, the higher molar ellipticity values registered for the former , together with slight shifts of the positions of the minima , indicate further stabilization of the helix about the latter ." 2586 2898 W2900439350.pdf 5 29 separator 0.8547579 ¶ 2899 2901 W2900439350.pdf 5 30 text 0.99930215 "The spectra deconvolution of P3 -Ll-2085 and P2 -Ll-1298 by SELCON 3 and CONTILL show ed contribution s of α-helix of over 70% and 50% , respectively ." 2901 3056 W2900439350.pdf 5 31 separator 0.993667 ¶ 3057 3059 W2900439350.pdf 5 32 caption 0.99572766 Figure 4. Circular dichroism spectra of synthetic analogs. ( A) water, ( B) TFE/ H2O (50%, v/v) (C) 3059 3159 W2900439350.pdf 5 33 separator 0.70201945 ¶ 3159 3161 W2900439350.pdf 5 34 caption 0.9714092 DPPG, ( D) DPPC. Peptide concentration: 0.2 mg/mL. 3161 3212 W2900439350.pdf 5 35 separator 0.9828152 ¶ 3212 3214 W2900439350.pdf 5 36 text 0.9993556 "The CD spectra showed that none of the compounds adopted a preferential conformation in water, which is consistent with the presence of a minimum at 198 nm. In the presence of TFE, P3-Ll-2085 adopted a helical conformation, an observation consistent with the presence of two minimums at 205–207 nm and 215–220 nm and a maximum at 195 nm." 3214 3558 W2900439350.pdf 5 37 separator 0.9502064 ¶ 3558 3560 W2900439350.pdf 5 38 text 0.99964494 "Deconvolution spectra by SELCON and CONTILL methods indicated more than 70% helical structure for P3-Ll-2085. P2-Ll-1298 also showed contributions of -helix, while P1-Ll-1577, although presenting contributions of turn structure, was less ordered in the presence of TFE (percentage of an unordered structure higher than 40%)." 3560 3892 W2900439350.pdf 5 39 separator 0.8626882 ¶ 3892 3894 W2900439350.pdf 5 40 text 0.9996215 In the presence of DPPG vesicles (Figure 4C), P3-Ll-2085 and P2-Ll-1298 adopted a helical structure. 3894 3995 W2900439350.pdf 5 41 separator 0.5730547 ¶ 3995 3997 W2900439350.pdf 5 42 text 0.99946135 "Nevertheless, the higher molar ellipticity values registered for the former, together with slight shifts of the positions of the minima, indicate further stabilization of the helix about the latter. The spectra deconvolution of P3-Ll-2085 and P2-Ll-1298 by SELCON 3 and CONTILL showed contributions of -helix of over 70% and 50%, respectively." 3997 4348 W2900439350.pdf 5 43 separator 0.96679604 ¶ 4348 4350 W2900439350.pdf 5 44 text 0.999587 "P1-Ll-1577 did not interact with DPPG vesicles, an observation that can be explained by its anionic character (net charge of" 4350 4477 W2900439350.pdf 5 0 paratext 0.9755297 ¶ 97 | rcf-Indonesia.org 1 27 W4391647546.pdf 1 1 separator 0.99474347 ¶ 60 62 W4391647546.pdf 1 2 text 0.98316365 "primer dengan menggunakan beberapa teknik sebagai berikut:" 63 125 W4391647546.pdf 1 3 separator 0.9867319 ¶ 127 129 W4391647546.pdf 1 4 title 0.87018424 a. Wawancara 129 142 W4391647546.pdf 1 5 separator 0.94449306 ¶ 144 146 W4391647546.pdf 1 6 text 0.9957444 "Yaitu dengan mengajukan pertanyaan kepada pi hak terkait untuk mendapatkan informasi yang dibutuhkan." 146 254 W4391647546.pdf 1 7 separator 0.99599516 ¶ 256 258 W4391647546.pdf 1 8 title 0.9713481 b. Obsevasi 258 270 W4391647546.pdf 1 9 separator 0.97643673 ¶ 272 274 W4391647546.pdf 1 10 text 0.99856347 "Observasi adalah melakukan pengamatan secara langsung di tempat penelitian untuk mengatahui secara jelas dan rinci tentang permasalahan yang ada." 274 426 W4391647546.pdf 1 11 separator 0.9965843 ¶ 428 430 W4391647546.pdf 1 12 title 0.9890633 2. Penelitian Pustaka ( Library Research ) 430 473 W4391647546.pdf 1 13 separator 0.992658 ¶ 474 476 W4391647546.pdf 1 14 text 0.9989924 "Penelitian yang dilakukan dengan menggunakan buku -buku yang berhubungan dengan pemecahan masalah dalam menunjang penyelesaian penulisan laporan ini. Adapun sumber tersebut didapatkan dari arsip -arsip yang ada pada data tersebut" 476 718 W4391647546.pdf 1 15 separator 0.99577045 ¶ 720 722 W4391647546.pdf 1 16 title 0.99052256 3. Pengujian Siste m 722 743 W4391647546.pdf 1 17 separator 0.99442136 ¶ 744 746 W4391647546.pdf 1 18 text 0.99813163 "Pada bagian pengujian program ini akan dijelaskan mengenai penggunaan dari aplikasi yang dibuat. Penjelasan aplikasi yang dibuat meliputi tampilan aplikasi, fungsi control dalam aplikasi, serta cara penggunaannya. Pada sub bab akan dijelaskan tentang pen ggunaan apliaksi per sistem menu, mulai dari tampilan menu utama, fungsi dan cara penggunaannya sampai selesai." 746 1134 W4391647546.pdf 1 19 separator 0.9932902 ¶ ¶ 1136 1142 W4391647546.pdf 1 20 title 0.9916382 3. RESULTS AND DISCUSSION 1142 1168 W4391647546.pdf 1 21 separator 0.99432003 ¶ ¶ 1170 1176 W4391647546.pdf 1 22 title 0.9910502 3.1. Tampilan Halaman Login 1176 1204 W4391647546.pdf 1 23 separator 0.9936442 ¶ 1206 1208 W4391647546.pdf 1 24 text 0.9981438 "Halaman login merupakan halaman yang akan ditampilkan pertama kali masuk ke menu. Halaman ini be risikan menu login yang akan digunakan pengguna untuk masuk ke dalam system dengan perintah localhost/reservasi/login.php dan admin harus menginputkan email dan password terlebih dahulu, seperti yang terlihat pada Gambar 1." 1208 1547 W4391647546.pdf 1 25 separator 0.9792346 ¶ ¶ 1548 1554 W4391647546.pdf 1 26 caption 0.97377825 Gambar 1. Halaman Login 1554 1578 W4391647546.pdf 1 27 separator 0.98938394 ¶ 1580 1582 W4391647546.pdf 1 28 title 0.9918666 4.1 Ta mpilan Halaman Utama 1582 1610 W4391647546.pdf 1 29 separator 0.99523586 ¶ 1612 1614 W4391647546.pdf 1 30 text 0.9973064 "Halaman utama adalah tampilan halaman awal admin setelah melakukan proses login. Halaman ini nantinya akan menampilkan menu -menu pilihan yang akan digunakan untuk melihat data data kamar pada sistem pendukung" 1614 1833 W4391647546.pdf 1 31 separator 0.99410164 ¶ 1835 1837 W4391647546.pdf 1 32 title 0.98956704 3.2. Form Data Kamar 1837 1858 W4391647546.pdf 1 33 separator 0.9945798 ¶ 1860 1862 W4391647546.pdf 1 34 text 0.99759865 "Form data kamar merupakan form yang digunakan oleh bagian admin untuk melihat jumlah kamar dan harga ." 1862 1971 W4391647546.pdf 1 35 separator 0.99308014 ¶ 1972 1974 W4391647546.pdf 1 36 title 0.9880128 3.3. Form Data pengguna 1974 1998 W4391647546.pdf 1 37 separator 0.99222606 ¶ 2000 2002 W4391647546.pdf 1 38 text 0.9960241 "Form data pengguna admin bisa melihat pengguna yg pernah memesan kamar, seperti yang terlihat pada Gambar 2." 2002 2117 W4391647546.pdf 1 39 separator 0.97830415 ¶ ¶ 2118 2124 W4391647546.pdf 1 40 caption 0.9859686 Gambar 2. Halaman Form Data pengguna 2124 2161 W4391647546.pdf 1 41 separator 0.991035 ¶ 2163 2165 W4391647546.pdf 1 42 title 0.9904958 3.4. Form Transaksi Pending 2165 2193 W4391647546.pdf 1 43 separator 0.99251896 ¶ 2195 2197 W4391647546.pdf 1 44 text 0.99749315 "Form transaksi pending ketika pengguna telah melakukan pemesan kamar akan tetapi belom di confirmasi oleh admin, seperti yang terlihat pada Gambar 3" 2197 2355 W4391647546.pdf 1 45 separator 0.82022494 "¶ ¶" 2356 2366 W4391647546.pdf 1 46 caption 0.89785945 Gambar 3. 11 Form Pending 2366 2392 W4391647546.pdf 1 47 separator 0.9896532 ¶ 2394 2396 W4391647546.pdf 1 48 title 0.9905027 3.5. Form Transaksi Confirm 2396 2424 W4391647546.pdf 1 49 separator 0.9917493 ¶ 2426 2428 W4391647546.pdf 1 50 text 0.99829763 "Form transaksi con firm admin dapat melihat data pengguna yang sudah di konfirmasikan pemesanannya seperti yang terlihat pada Gambar 4." 2428 2570 W4391647546.pdf 1 51 separator 0.9966853 ¶ 2571 2573 W4391647546.pdf 1 0 paratext 0.9883495 Tomczak, I., and Pétri, J.: A&A 676, A128 (2023) 0 48 W4383292599.pdf 18 1 separator 0.9375284 ¶ 48 50 W4383292599.pdf 18 2 title 0.3283389 ( 50 52 W4383292599.pdf 18 3 math 0.41467798 "a) (b) (c) (d)" 52 68 W4383292599.pdf 18 4 separator 0.9938612 ¶ 68 70 W4383292599.pdf 18 5 caption 0.9943797 "Fig. 27. Lorentz factor distribution of protons trapped around neutron stars with an inclination of =60(a),=90(b),=120(c), and =150(d). Radiation reaction was enabled." 70 248 W4383292599.pdf 18 6 separator 0.5299628 ¶ 248 250 W4383292599.pdf 18 7 caption 0.5651375 found 250 256 W4383292599.pdf 18 8 math 0.8617514 "that = 60E2 q!1=4 = q Ek m c rL re ̃2!1=4 : (14)" 256 323 W4383292599.pdf 18 9 separator 0.9692585 ¶ 323 325 W4383292599.pdf 18 10 text 0.99382824 "This last expression uses quantities without dimensions, such as ̃==rL, and the electric strength parameter, with rebeing the electron classical radius and Ek= Eas the accelerating elec- tric field. In our case, we applied the expression to millisecond pulsars and got =107:5, which is only a guess because the curvature radius can be very di erent from that on the stellar surface. The true curvature is found from the velocity vector derivative such that " 325 802 W4383292599.pdf 18 11 separator 0.44885302 ¶ 802 803 W4383292599.pdf 18 12 math 0.7639607 "=1 = dv c2dt : (15)" 803 837 W4383292599.pdf 18 13 separator 0.96209735 ¶ 837 839 W4383292599.pdf 18 14 text 0.9988099 "This expression accurately captures the local curvature radius along the trajectory. Therefore, by following the Lorentz factor from the Landau-Lifshitz approximation and comparing it to the radiation reaction limit estimate as given by Eq. (14), we show that the latter always finds higher Lorentz factors, see Fig. 21." 839 1169 W4383292599.pdf 18 15 separator 0.96365124 ¶ 1169 1171 W4383292599.pdf 18 16 text 0.9985219 "To check that the results converged, several di erent time step integration parameters were used, two times as well as five times smaller without noticeable changes. Thus, our results have con- verged and are robust." 1171 1394 W4383292599.pdf 18 17 separator 0.97239786 ¶ 1394 1396 W4383292599.pdf 18 18 text 0.99910754 "We note that the Lorentz factors of trapped particles span a large range from almost rest 10 to .108. This does not necessarily mean that they always experience strong radia- tion damping. Indeed, the Lorentz factor variation is two-fold in this electromagnetic field environment. First, the radiation reac- tion decelerates the particles from a very high Lorentz factor of 1012" 1396 1789 W4383292599.pdf 18 0 paratext 0.9895005 Cells 2022 ,11, 834 3 of 5 0 26 W4214665561.pdf 2 1 separator 0.9946084 ¶ 26 28 W4214665561.pdf 2 2 text 0.99970067 "Maria Ankarcrona et al. [ 21] deals with an emerging aspect in neurodegeneration which is the altered communication between the endoplasmic reticulum (ER) and mito- chondria. The authors reported an increased juxtaposition between ER and mitochondria in the brain of different AD mouse models, in primary neurons from these mice, as well as in wild-type neurons treated with A . Importantly, the potentiated inter-organelle tethering found in these cells is linked to dysfunctions in autophagy and mitochondrial bioenergetics." 28 566 W4214665561.pdf 2 3 separator 0.9515947 ¶ 566 568 W4214665561.pdf 2 4 text 0.99977034 "Ultimately, three different papers analyzed the role played by presenilin 2 (PS2), one of the three mutated proteins causing familial AD (FAD), in determining, by multiple means, neuronal dysfunction and degeneration. Firstly, Giulia Rigotto et al. [ 22] investigated possible mitochondrial alterations in neurons from FAD-PS2 mice, as a key mechanism for neurodegeneration. They found defects in mitochondrial respiration, organelle membrane potential and Ca2+handling in AD neurons under mild stress that were partially rescued by an inhibitor of the mitochondrial permeability transition pore, proposing the latter as a possible tuneable target to potentiate mitochondrial and cellular function in AD. Alice Rossi et al. [ 23] investigated the role of endogenous PS2 in neuronal function, by using knock-out (KO) animals for the protein. They showed that PS2-KO primary cortical neurons present a decreased ER-mitochondria coupling and a blunted mitochondrial Ca2+signal upon neuronal stimulation, as well as a slight alteration in organelle respiration, confirming the key role played by PS2 in keeping mitochondrial health. Moreover, the paper by Michela Rossini et al. [ 24] identified the domain of PS2 which is involved in the previously described capacity of the protein to reinforce ER-mitochondria coupling. Specifically, the sole cytosolic loop of PS2, when targeted to the mitochondrial surface, was able to counteract the activity of FAD-PS2 mutants on organelle tethering, proving itself as a possible tool for recovering FAD-PS2-associated alterations linked to this signaling axis." 568 2198 W4214665561.pdf 2 5 separator 0.98017716 ¶ 2198 2200 W4214665561.pdf 2 6 text 0.99977523 "Last, but not least, two interesting reviews present different tools and animal mod- els available for studying Ca2+signaling in neuronal physiology and during aging and neurodegeneration. The first, by Nelly Redolfi et al. [ 25], is an overview of the most used model organisms employed for Ca2+imaging in brain research, from D. melanogaster to C. elegans , from different transgenic mouse models to zebrafish lines, underlining their specific applications in the field. The review by Javier Alvarez, Mayte Montero and collabo- rators [ 26], instead, focuses only on C. elegans , presenting all the advantages in using the nematode as a model organism to understand in vivo the role of Ca2+signaling in aging and neurodegeneration, being transparent throughout its life, and thus suitable for the expression of Ca2+fluorescent probes, and presenting gene mutations linked to different neurodegenerative diseases." 2200 3129 W4214665561.pdf 2 7 separator 0.98565674 ¶ 3129 3131 W4214665561.pdf 2 8 text 0.99977255 "In addition to the importance of better defining the early events leading to neurode- generation, a key step in the effort of preventing the onset of blocking the progression of neurodegenerative disorders is the development of methods and tools for an early and precise diagnosis. Indeed, one of the reasons underlying the lack of success of several clinical trials is likely a tardive patient recruitment, i.e., when the symptoms are evident and the degenerative process is already irremediable. In this context, the use of free-water imaging to detect and distinguish neuronal degeneration and neuroinflammation in the white and grey matter of PD patients, as shown by Koji Kamagata and co-workers [ 27], appears promising. Similarly, in a FAD mouse model, the finding of early (i.e., before amyloid deposition), specific patterns of alterations in brain electrical activity suggests the possibility to use this tool for an early AD diagnosis, as presented by Cristina Fasolato and collaborators [ 28]. Moreover, in the paper by Lu Zhao et al. [ 29], the introduction of novel tools to investigate in vitro and in vivo the activation of specific cell pathways, such as the pHluorin-BACE1-mCherry reporter for BACE1 distribution and activity, appears of utmost importance to screen possible therapeutic candidates." 3131 4471 W4214665561.pdf 2 9 separator 0.9785863 ¶ 4471 4473 W4214665561.pdf 2 10 text 0.99934363 "In conclusion, this Special Issue provides new molecular advice to sketch a better scenario for understanding aging processes and neurodegenerative events, stimulating further research for the development of early and efficient therapeutic interventions for related pathologies." 4473 4757 W4214665561.pdf 2 0 paratext 0.9078754 "Molecules 2006 , 11 ¶ 747" 0 33 W2125343127.pdf 8 1 separator 0.991501 ¶ 33 35 W2125343127.pdf 8 2 text 0.9969316 "To a 250 mL stainless reactor, were added a magnetic stir bar, L-isoleucine (5.009 g, 38.2 mmol) and thiourea (5.836 g, 76.8 mmol). After sealing, the reactor was immersed halfway into an oil bath preheated to 195oC, and stirred magnetically. At differe nt intervals, the metal reactor was taken out of oil bath and the contents sampled to monitor the completion of reaction by TLC. When the reaction was complete, water was added into the reactor to wash out the resulting product, which was purified in a similar way to that described in the oil bath treatment to afford 5.65 g of ( S)-5-sec-butyl-2- thiohydantoin (86% yield). As it was very difficult and inconvenient to monitor the reaction under these conditions, no further reactions of thiourea with other amino acids were carried out using this setup." 35 868 W2125343127.pdf 8 3 separator 0.9877552 ¶ ¶ 869 875 W2125343127.pdf 8 4 title 0.9736092 Table 3. NMR data of prepared 2-thiohydantoins.* 875 924 W2125343127.pdf 8 5 separator 0.9950576 ¶ 925 927 W2125343127.pdf 8 6 title 0.91949713 Compound NMR data 927 945 W2125343127.pdf 8 7 separator 0.9762095 ¶ 946 948 W2125343127.pdf 8 8 table 0.6245703 "Gly-thiohydantoin 1H-NMR (DMSO-d 6, 303K): 4.03 (dd, J 1=14.67, J 2=6.54 Hz, 2 H, α-H), 9.80 (s, 1H, NH), 11.61 (s, 1 H, NH); 13C-NMR (DMSO-d 6, 303K): 54.21 ( α-C), 178.40, 187.38." 948 1133 W2125343127.pdf 8 9 separator 0.640841 ¶ 1134 1136 W2125343127.pdf 8 10 table 0.49467364 Ala-thiohydantoin 1H-NMR (DMSO-d 6, 303K): 1.22 1136 1184 W2125343127.pdf 8 11 text 0.45177466 ( 1184 1186 W2125343127.pdf 8 12 table 0.4619268 d, 1186 1188 W2125343127.pdf 8 13 text 0.46229333 J= 1188 1191 W2125343127.pdf 8 14 table 0.58077395 "6.14 Hz, 3 H, β-H on Me), 4.01 (q, J=6.15 Hz, 1 H, α-H), 9.05 (s, 1 H, NH), 10.56 (s, 1 H, NH); 13C-NMR (DMSO-d 6, 303K): 21.75 (β-C), 51.19 ( α-C), 181.17, 186.00." 1191 1361 W2125343127.pdf 8 15 separator 0.8205538 ¶ 1362 1364 W2125343127.pdf 8 16 table 0.5180924 Val 1364 1368 W2125343127.pdf 8 17 text 0.48123088 - 1368 1369 W2125343127.pdf 8 18 table 0.46193868 thiohydantoin 1H 1369 1385 W2125343127.pdf 8 19 text 0.46363822 -NMR 1385 1389 W2125343127.pdf 8 20 table 0.45515585 ( 1389 1391 W2125343127.pdf 8 21 text 0.4632423 DMSO- 1391 1396 W2125343127.pdf 8 22 table 0.43543443 d 1396 1397 W2125343127.pdf 8 23 text 0.43956754 6, 303K 1397 1405 W2125343127.pdf 8 24 table 0.4945823 ): 0.83 (d, 1405 1416 W2125343127.pdf 8 25 text 0.47547314 J=6 1416 1420 W2125343127.pdf 8 26 table 0.5059509 . 1420 1421 W2125343127.pdf 8 27 text 0.5213129 79 1421 1423 W2125343127.pdf 8 28 table 0.56509906 "Hz, 3 H, Me), 0.97 (d, J=6.95 Hz, 3 H, Me), 2.02-2.08 (m, 1 H, β-H), 4.10 (d, J=3.39 Hz, 1 H, α-H), 9.99 (s, 1 H, NH), 11.60" 1423 1551 W2125343127.pdf 8 29 text 0.41563267 ¶ 1552 1554 W2125343127.pdf 8 30 table 0.4726199 (s, 1 H, NH); 13C-NMR (DMSO-d 1554 1584 W2125343127.pdf 8 31 text 0.4261965 6, 1584 1587 W2125343127.pdf 8 32 table 0.4933367 "303K): 20.05 ( γ-C), 22.20 ( γ-C), 33.93 ( β-C), 69.73 (α-C), 179.85, 186.91." 1587 1668 W2125343127.pdf 8 33 separator 0.9124581 ¶ 1669 1671 W2125343127.pdf 8 34 table 0.505901 Le 1671 1674 W2125343127.pdf 8 35 text 0.48488146 u- 1674 1676 W2125343127.pdf 8 36 table 0.4715309 thiohydantoin 1676 1689 W2125343127.pdf 8 37 text 0.45272696 1 1689 1691 W2125343127.pdf 8 38 table 0.465985 H- 1691 1693 W2125343127.pdf 8 39 text 0.46207842 NMR ( 1693 1698 W2125343127.pdf 8 40 table 0.46061555 aceto 1698 1703 W2125343127.pdf 8 41 text 0.46407014 ne- 1703 1706 W2125343127.pdf 8 42 table 0.43930432 d 1706 1707 W2125343127.pdf 8 43 text 0.46706432 6, 1707 1710 W2125343127.pdf 8 44 table 0.44842762 280 1710 1714 W2125343127.pdf 8 45 text 0.4725808 K): 1714 1717 W2125343127.pdf 8 46 table 0.46959534 1717 1718 W2125343127.pdf 8 47 text 0.5201876 0.97 (d, J=6.64 Hz, 6 H, 2 1718 1744 W2125343127.pdf 8 48 table 0.4769926 Me), 1744 1749 W2125343127.pdf 8 49 text 0.46436864 1.63-1.68 ( 1749 1760 W2125343127.pdf 8 50 table 0.47141036 m 1760 1761 W2125343127.pdf 8 51 text 0.47443083 , 2 1761 1764 W2125343127.pdf 8 52 table 0.48064294 H, β-H 1764 1771 W2125343127.pdf 8 53 text 0.4848377 "), 1.91-1.98 (m, 1 H, γ-H)," 1771 1801 W2125343127.pdf 8 54 table 0.45097402 4.34 1801 1806 W2125343127.pdf 8 55 text 0.43421593 ( 1806 1808 W2125343127.pdf 8 56 table 0.4502573 dd 1808 1810 W2125343127.pdf 8 57 text 0.45848447 , 1810 1811 W2125343127.pdf 8 58 table 0.41394064 J 1811 1813 W2125343127.pdf 8 59 text 0.45344558 1=8.58, J 2=5.22 Hz, 1813 1834 W2125343127.pdf 8 60 table 0.4236028 1 H 1834 1838 W2125343127.pdf 8 61 text 0.44297442 , 1838 1840 W2125343127.pdf 8 62 table 0.4250266 α 1840 1841 W2125343127.pdf 8 63 text 0.43981665 - 1841 1842 W2125343127.pdf 8 64 table 0.40832362 H 1842 1843 W2125343127.pdf 8 65 text 0.42798966 ), 1843 1846 W2125343127.pdf 8 66 table 0.44484293 9.14 1846 1850 W2125343127.pdf 8 67 text 0.42300105 ( 1850 1852 W2125343127.pdf 8 68 table 0.44678855 s 1852 1853 W2125343127.pdf 8 69 text 0.4567555 , 1853 1854 W2125343127.pdf 8 70 table 0.44670302 1 H 1854 1858 W2125343127.pdf 8 71 text 0.44521096 , 1858 1859 W2125343127.pdf 8 72 table 0.42014056 NH 1859 1862 W2125343127.pdf 8 73 text 0.466437 "), 10.63 (" 1862 1875 W2125343127.pdf 8 74 table 0.40456784 s 1875 1876 W2125343127.pdf 8 75 text 0.44043437 , 1 H, NH); 13 1876 1890 W2125343127.pdf 8 76 table 0.41086337 C 1890 1891 W2125343127.pdf 8 77 text 0.44449833 -NMR ( 1891 1897 W2125343127.pdf 8 78 table 0.41193444 aceto 1897 1902 W2125343127.pdf 8 79 text 0.41519406 ne-d 6, 280K): 1902 1916 W2125343127.pdf 8 80 table 0.41882405 12.08 (Me 1916 1926 W2125343127.pdf 8 81 text 0.3867947 ), 1926 1928 W2125343127.pdf 8 82 table 0.43566224 "13.69 (Me), 15.51 ( γ- C), 31.28 ( β-C), 50.76 ( α-C" 1928 1983 W2125343127.pdf 8 83 text 0.3745051 ), 1983 1985 W2125343127.pdf 8 84 table 0.41934735 167.23, 17 1985 1996 W2125343127.pdf 8 85 text 0.43288818 4.04. 1996 2001 W2125343127.pdf 8 86 separator 0.9530541 ¶ 2002 2004 W2125343127.pdf 8 87 text 0.4608875 Ile-thiohy 2004 2015 W2125343127.pdf 8 88 table 0.43148363 dantoin 2015 2022 W2125343127.pdf 8 89 text 0.40204528 ( 2022 2024 W2125343127.pdf 8 90 table 0.41039783 S 2024 2026 W2125343127.pdf 8 91 text 0.41632527 ,S 2026 2028 W2125343127.pdf 8 92 table 0.3927069 ) 2028 2029 W2125343127.pdf 8 93 text 0.4183699 - and ( R,S)-dias 2029 2046 W2125343127.pdf 8 94 table 0.4197699 teromeric mixtures in a ratio of 2046 2079 W2125343127.pdf 8 95 text 0.4348188 1.38:1; 2079 2086 W2125343127.pdf 8 96 table 0.40504962 1H 2086 2089 W2125343127.pdf 8 97 text 0.4203127 -NMR ( 2089 2095 W2125343127.pdf 8 98 table 0.42157876 acetone-d 2095 2104 W2125343127.pdf 8 99 text 0.43341893 "6, 298K): " 2104 2118 W2125343127.pdf 8 100 table 0.40061057 0.89 2118 2122 W2125343127.pdf 8 101 text 0.46102026 "(d, J=6.78 Hz, β-Me, 1.9 H), 0.93 (t, J=7.50 Hz, δ-Me, 1.1 H), 0.97 (t, J =7.38 Hz, δ-Me, 1.6 H), 1.04 (d, J=6.96 Hz," 2122 2243 W2125343127.pdf 8 102 table 0.3768727 β 2243 2245 W2125343127.pdf 8 103 text 0.38853583 - 2245 2246 W2125343127.pdf 8 104 table 0.36451462 Me 2246 2248 W2125343127.pdf 8 105 text 0.40829992 , 1.40 H), 1.30-1.43 (m, 2248 2272 W2125343127.pdf 8 106 table 0.37021554 γ 2272 2274 W2125343127.pdf 8 107 text 0.39992693 - 2274 2275 W2125343127.pdf 8 108 table 0.36757356 H 2275 2276 W2125343127.pdf 8 109 text 0.41876948 ", 1H), 1.48-1.60 (m, γ-H, 1H), 4.28 (d, J=3.66 Hz, H-5," 2276 2334 W2125343127.pdf 8 110 table 0.38495195 2334 2335 W2125343127.pdf 8 111 text 0.38867426 0.42 H), 2335 2343 W2125343127.pdf 8 112 table 0.41518325 4.34 2343 2348 W2125343127.pdf 8 113 text 0.37522742 ( 2348 2350 W2125343127.pdf 8 114 table 0.32893077 d 2350 2351 W2125343127.pdf 8 115 text 0.39934096 , J= 2351 2355 W2125343127.pdf 8 116 table 0.3961238 3.18 2355 2359 W2125343127.pdf 8 117 text 0.3893366 2359 2360 W2125343127.pdf 8 118 table 0.35035875 Hz 2360 2362 W2125343127.pdf 8 119 text 0.39854056 ", H-5, 0.59 H), 8.96 (" 2362 2387 W2125343127.pdf 8 120 table 0.3574019 s 2387 2388 W2125343127.pdf 8 121 text 0.39096907 , 2388 2389 W2125343127.pdf 8 122 table 0.3755212 1 H 2389 2393 W2125343127.pdf 8 123 text 0.37248752 , 2393 2394 W2125343127.pdf 8 124 table 0.36635107 NH 2394 2397 W2125343127.pdf 8 125 text 0.35257626 ), 2397 2399 W2125343127.pdf 8 126 table 0.4125249 10 2399 2402 W2125343127.pdf 8 127 text 0.38995355 .55 2402 2405 W2125343127.pdf 8 128 table 0.383033 (s 2405 2408 W2125343127.pdf 8 129 text 0.34078804 , 2408 2409 W2125343127.pdf 8 130 table 0.378819 1 H 2409 2413 W2125343127.pdf 8 131 text 0.35893854 , 2413 2414 W2125343127.pdf 8 132 table 0.3766558 NH 2414 2417 W2125343127.pdf 8 133 text 0.36583656 ); 13 2417 2422 W2125343127.pdf 8 134 table 0.36560705 C 2422 2423 W2125343127.pdf 8 135 text 0.39293098 -NMR (acetone-d 6, 298K): 2423 2449 W2125343127.pdf 8 136 table 0.40994376 2.17 2449 2453 W2125343127.pdf 8 137 text 0.42815325 ¶ 2454 2456 W2125343127.pdf 8 138 table 0.346619 (Me 2456 2460 W2125343127.pdf 8 139 math 0.33793977 ), 2460 2462 W2125343127.pdf 8 140 table 0.45342848 2.30 (Me), 3.92 (Me), 5.48 (Me), 14.84 ( γ-C), 16.78 ( γ-C), 28.16 ( β-C), 28.24 2462 2543 W2125343127.pdf 8 141 text 0.39795938 ¶ 2544 2546 W2125343127.pdf 8 142 table 0.45333335 (β-C), 55.91 (C-5), 56.75 (C-5), 166.18, 166.67, 174.29, 174.61. 2546 2611 W2125343127.pdf 8 143 separator 0.9565686 ¶ 2612 2614 W2125343127.pdf 8 144 table 0.48641664 Met 2614 2618 W2125343127.pdf 8 145 text 0.47058043 - 2618 2619 W2125343127.pdf 8 146 table 0.44283605 thiohy 2619 2625 W2125343127.pdf 8 147 text 0.45568597 dantoin 1 2625 2634 W2125343127.pdf 8 148 table 0.43468133 H 2634 2635 W2125343127.pdf 8 149 text 0.47239417 -NMR (DMSO-d 6, 303K): 1.81-1.86 (m, 1 2635 2673 W2125343127.pdf 8 150 table 0.4747637 H, β- 2673 2678 W2125343127.pdf 8 151 text 0.44916964 H), 2678 2681 W2125343127.pdf 8 152 table 0.44567528 2681 2682 W2125343127.pdf 8 153 text 0.48938534 1.93-1.97 (m, 2682 2695 W2125343127.pdf 8 154 table 0.487928 1 H, β-H 2695 2704 W2125343127.pdf 8 155 text 0.47397912 ), 2704 2707 W2125343127.pdf 8 156 table 0.4488343 2.05 2707 2711 W2125343127.pdf 8 157 text 0.5356382 ¶ (d, J=0.82 Hz, 3 H, Me), 2.54 2712 2744 W2125343127.pdf 8 158 table 0.44469467 - 2744 2745 W2125343127.pdf 8 159 text 0.4983116 2.57 ( 2745 2751 W2125343127.pdf 8 160 table 0.4389039 m 2751 2752 W2125343127.pdf 8 161 text 0.4624772 , 2 2752 2755 W2125343127.pdf 8 162 table 0.4672571 H, γ-H 2755 2762 W2125343127.pdf 8 163 text 0.40856537 ), 2762 2764 W2125343127.pdf 8 164 table 0.4449466 4.30 2764 2769 W2125343127.pdf 8 165 text 0.42676768 ( 2769 2771 W2125343127.pdf 8 166 table 0.45718932 dd 2771 2773 W2125343127.pdf 8 167 text 0.46808508 , J 1=6.75, J 2=6.06 2773 2794 W2125343127.pdf 8 168 table 0.43800616 Hz 2794 2796 W2125343127.pdf 8 169 text 0.46740353 , 1 H, ¶ 2796 2805 W2125343127.pdf 8 170 table 0.45884264 α 2805 2807 W2125343127.pdf 8 171 text 0.44113946 -H); 13C-NMR (DMSO-d 6, 303K): 18.38 2807 2843 W2125343127.pdf 8 172 table 0.4292933 (Me), 2843 2849 W2125343127.pdf 8 173 text 0.4754792 32.56 2849 2855 W2125343127.pdf 8 174 table 0.46193206 ( γ-C), 3 2855 2865 W2125343127.pdf 8 175 text 0.4309163 4.21 2865 2869 W2125343127.pdf 8 176 table 0.44370568 ( β-C), 63.45 ( α- 2869 2888 W2125343127.pdf 8 177 text 0.4250126 ¶ 2888 2890 W2125343127.pdf 8 178 table 0.42169538 C 2890 2892 W2125343127.pdf 8 179 text 0.3966862 ), 2892 2894 W2125343127.pdf 8 180 table 0.4260322 180.21, 18 2894 2905 W2125343127.pdf 8 181 text 0.4489805 6.49. 2905 2910 W2125343127.pdf 8 182 separator 0.92950654 ¶ 2911 2913 W2125343127.pdf 8 183 table 0.47681367 Ph 2913 2916 W2125343127.pdf 8 184 text 0.49590403 e-thiohydantoin 1H-NMR (acetone-d 6, 280K): 2916 2959 W2125343127.pdf 8 185 table 0.46169043 3.09 (d 2959 2967 W2125343127.pdf 8 186 text 0.46785182 d, J 1 2967 2973 W2125343127.pdf 8 187 table 0.4596435 =14.20, 2973 2980 W2125343127.pdf 8 188 text 0.50515246 J 2=5.92 Hz, 1 H 2980 2997 W2125343127.pdf 8 189 table 0.46047482 , β-H), 3.21 2997 3009 W2125343127.pdf 8 190 text 0.43195328 ( 3009 3011 W2125343127.pdf 8 191 table 0.49150208 dd 3011 3013 W2125343127.pdf 8 192 text 0.45812675 , J 1 3013 3018 W2125343127.pdf 8 193 table 0.40414464 = 3018 3019 W2125343127.pdf 8 194 text 0.4929508 ¶ 14.15, J 2=4.7 Hz, 1 3020 3043 W2125343127.pdf 8 195 table 0.42384586 H 3043 3045 W2125343127.pdf 8 196 text 0.42864937 , 3045 3046 W2125343127.pdf 8 197 table 0.4280591 β-H), 3046 3052 W2125343127.pdf 8 198 text 0.5033918 4.63 3052 3057 W2125343127.pdf 8 199 table 0.4692428 (t, J=4.8 Hz, 1 H, α-H), 3057 3082 W2125343127.pdf 8 200 text 0.49158612 7.24-7.31 (m, 5 H, 3082 3101 W2125343127.pdf 8 201 table 0.4291042 Ph 3101 3104 W2125343127.pdf 8 202 text 0.4528073 ), 3104 3107 W2125343127.pdf 8 203 table 0.44783482 9.10 3107 3111 W2125343127.pdf 8 204 text 0.49525535 ¶ ( 3112 3116 W2125343127.pdf 8 205 table 0.4552833 s 3116 3117 W2125343127.pdf 8 206 text 0.42059612 , 3117 3118 W2125343127.pdf 8 207 table 0.45276326 1 H, NH), 3118 3128 W2125343127.pdf 8 208 text 0.4859771 10.47 3128 3134 W2125343127.pdf 8 209 table 0.459486 (s, 1 H, NH); 3134 3148 W2125343127.pdf 8 210 text 0.41957852 13 3148 3151 W2125343127.pdf 8 211 table 0.4329652 C 3151 3152 W2125343127.pdf 8 212 text 0.41705954 -N 3152 3154 W2125343127.pdf 8 213 table 0.4140679 MR (acetone-d 3154 3167 W2125343127.pdf 8 214 text 0.4085356 6, 280 3167 3174 W2125343127.pdf 8 215 table 0.415792 K): 27. 3174 3181 W2125343127.pdf 8 216 text 0.40014762 58 3181 3183 W2125343127.pdf 8 217 table 0.42984846 ( β-C), 53.40 ( α- 3183 3202 W2125343127.pdf 8 218 text 0.40460545 ¶ 3202 3204 W2125343127.pdf 8 219 table 0.4797799 C), 118.24 (Ph), 119.59 (Ph), 120.97 (Ph), 126.58 (Ph), 166.12, 174.15. 3204 3276 W2125343127.pdf 8 220 separator 0.9928093 ¶ 3277 3279 W2125343127.pdf 8 0 bibliography 0.99740016 "[4]Ronald J. Gould, Advances on the Hamiltonian problem –a survey , Graph Combin. 19(2003 ),7–52, DOI: 10.1007/s00373 - 002 -0492 -x." 0 135 W3046092592.pdf 9 1 separator 0.9851055 ¶ 135 137 W3046092592.pdf 9 2 bibliography 0.9964919 "[5]Genghua Fan, New sufficient conditions for cycles in graph , J. Combin. Theory Ser. B 37 (1984 ), no. 3, 221 –227, DOI: 10.1016/0095 -8956 (84)90054 -6." 137 293 W3046092592.pdf 9 3 separator 0.98229784 ¶ 293 295 W3046092592.pdf 9 4 bibliography 0.99725825 "[6]Igor Fabrici, Erhard Hexel, and Stanislav Jendro ’,On vertices enforcing a hamiltonian cycle , Discuss. Math. Graph Theory 33 (2013 ), no. 1, 71 –89, DOI: 10.7151/dmgt.1653." 295 474 W3046092592.pdf 9 5 separator 0.98298234 ¶ 474 476 W3046092592.pdf 9 6 bibliography 0.99724436 "[7]Xinhong Zhang, Ruijuan Li, and Shengjia Li, H-force sets of locally semicomplete digraphs , Discrete Appl. Math. 160 (2012 ), no. 16 –17, 2491 –2496, DOI: 10.1016/j.dam.2012.06.014." 476 663 W3046092592.pdf 9 7 separator 0.9782796 ¶ 663 665 W3046092592.pdf 9 8 bibliography 0.99700856 "[8]Ruijuan Li, Xinhong Zhang, Shengjia Li, Qiaoping Guo, and Yubao Guo, The H -force set of a hypertournament , Discrete Appl. Math. 169 (2014 ), 168 –175, DOI: 10.1016/j.dam.2013.12.020." 665 855 W3046092592.pdf 9 9 separator 0.97298604 ¶ 855 857 W3046092592.pdf 9 10 bibliography 0.9979077 [9]Oystein Ore, Note on Hamilton circuits , Amer. Math. Monthly 67 (1960 ), no. 1, 55, DOI: 10.2307/2308928. 857 966 W3046092592.pdf 9 11 separator 0.96272206 ¶ 966 968 W3046092592.pdf 9 12 bibliography 0.9922745 "[10]Gabriel Andrew Dirac, Some theorems on abstract graphs , Proc. London Math. Soc. s3-2(1952 ), no. 1, 69 –81, DOI: 10.1112/plms/s3 -2.1.69.780 Xinhong Zhang and Ruijuan Li" 968 1146 W3046092592.pdf 9 0 text 0.9875677 "Scientific Research Publishing (SCIRP) is one of the largest Open Access journal publishers. It is currently publishing more than 200 open access, online, peer- reviewed journals covering a wide range of academic disciplines. SCIRP serves the worldwide academic communities and contributes to the progress and application of science with its publication." 0 360 W1994608847.pdf 7 1 separator 0.7874877 ¶ ¶ 362 368 W1994608847.pdf 7 2 text 0.81748605 Other selected journals from SCIRP are listed as below. 368 426 W1994608847.pdf 7 3 contact 0.5536569 "Submit your manuscript to us via e ither submit@scirp.org or Online Submission Portal" 426 518 W1994608847.pdf 7 4 text 0.48055187 . 518 520 W1994608847.pdf 7 5 separator 0.9015801 "¶ ¶ ¶ ¶" 521 555 W1994608847.pdf 7 0 paratext 0.9831075 Jurnal Magistrorum Et Scholarium, Volume 0 4 Nomor 0 1, Agustus 2023, 48-56 0 75 W4391260508.pdf 1 1 separator 0.7529595 ¶ ¶ 76 82 W4391260508.pdf 1 2 paratext 0.91010076 49 82 85 W4391260508.pdf 1 3 title 0.9874419 PENDAHULUAN 85 97 W4391260508.pdf 1 4 separator 0.9909748 ¶ ¶ 99 105 W4391260508.pdf 1 5 text 0.99928814 "Masyarakat di era Society 5.0 menjadi sebuah kelompok masyarakat yang tidak bisa lepas dari teknologi dan internet. Teknologi dan internet telah menjadi sebuah kebutuhan." 106 281 W4391260508.pdf 1 6 separator 0.5555799 ¶ 282 284 W4391260508.pdf 1 7 text 0.9972189 "Teknologi dan internet telah menjadi bagian integral dari kehidupan sehari -hari yang memfasilitasi komunikasi, pen didikan, dan hiburan (Kurniasanti et al., 2019) . Hal ini terjadi di semua kalangan usia, dari usia dini hingga usia lanjut, termasuk juga usia remaja. Terutama bagi para remaja dengan kebutuhan relasi sosial, menyebabkan mudahnya seseorang lebih merasa nyaman dan santai bila melakukan hubungan melalui internet (Saragih, 2020) . Adanya Pandemi Covid -19 juga semakin melekatkan kehidupan dengan teknologi dan internet. Adanya peningkatan frekuensi dan durasi penggunaan interne t untuk hiburan, hingga menyebabkan pola pengaturan waktu yang tidak teratur bagi seseorang yang menyebabkan berubahnya waktu bekerja, dan atau kece nderungan begadang. Oleh karena itu, diperlukan tindakan preventif dan penguatan bagi seluruh masyarakat te rutama anak -anak dan remaja yang telah melalui masa pandemi sehingga mampu mengelola waktu (Dong et al., 2020) ." 284 1284 W4391260508.pdf 1 8 separator 0.9819089 ¶ 1285 1287 W4391260508.pdf 1 9 text 0.9993065 "Salah satu tantangan besar yang harus dihadapi remaja saat ini ialah terbukanya arus informasi yang luas serta tidak ada batasan untuk mengaksesnya. Perkembangan teknologi dan informasi sedang mengalami kemajuan yang sangat pesat yang bi sa dirasakan akhir -akhir ini." 1287 1562 W4391260508.pdf 1 10 separator 0.8154925 ¶ 1563 1565 W4391260508.pdf 1 11 text 0.99920195 "Meningkatnya penggunaan gadget berupa smartphone serta alat -alat yang dapat dengan mudah terkoneksi dengan internet menjadi pertanda perkembangan tersebut . Di sisi lain, melalui internet juga remaja mendapatkan informasi dan h al baru yang terkadang tidak sesuai dengan budaya Indonesia sehingga hal tersebut menjadi kurang sesuai dengan konteks remaja Indonesia apabila remaja tidak mengolah informasi secara tepat (Desiningrum et al., 2017) ." 1565 2028 W4391260508.pdf 1 12 separator 0.98565626 ¶ 2029 2031 W4391260508.pdf 1 13 text 0.9990148 "Menurut survey Badan Pusa t Statistik (BPS) bekerjasama dengan Asosiasi Penyelenggara Jasa Internet Indonesia (APJII) mencatat bahwa angka pertumbuhan pengguna gawai di Indonesia hingga akhir tahun 2021 mencapai 196,7 juta orang dari total 256,2 juta penduduk Indonesia. Penggunaan internet sebagian besar perangkat yang paling sering digunakan untuk mengakses internet ialah gawai sebanyak 47,6%, mengakses internet menggunakan komputer 1,7% dan 50,7% menggunakan perangkat gawai dan komputer (Pratiwi et al., 2022) ." 2031 2570 W4391260508.pdf 1 14 separator 0.9795799 ¶ 2571 2573 W4391260508.pdf 1 15 text 0.9992571 Perkembangan teknologi pada era digital ini tidak dapat dipungkiri sangat pesat adanya. 2573 2661 W4391260508.pdf 1 16 separator 0.77668226 ¶ 2662 2664 W4391260508.pdf 1 17 text 0.9995378 "Salah satu produk perkembangan teknologi yang saat ini digemari remaja adalah game online berbasis internet . Semest inya game online dimanfaatkan untuk hiburan tetapi yang terjadi game online dimainkan secara berlebihan, digunakan sebagai tempat untuk melarikan diri dari realitas kehidupan sehingga yang terjadi adalah kecanduan game online . Hal ini akan berakibat buruk terhadap berbagai aspek kehidupan remaja. Dengan demikian remaja perlu diberikan upaya pe ncegahan terhadap kecanduan internet yang berupa game online (Novrialdy, 2019) ." 2664 3230 W4391260508.pdf 1 18 separator 0.9736754 ¶ 3231 3233 W4391260508.pdf 1 19 text 0.9985835 "Kecanduan gadget adalah suatu kelekatan yang kompleks pada penggunaan gadget, yang menyebabkan ketegantungan individu tersebut yang dapat merugikan kondisi tubuhnya (Alrasheed & Aprianti, 2016) ." 3233 3435 W4391260508.pdf 1 20 separator 0.9749708 ¶ 3436 3438 W4391260508.pdf 1 21 text 0.9995043 "Penggunaan teknologi dan internet berlebihan dapat mengarah kepada kecenderungan kecanduan yang menimbulkan efek sosial (Cho u et al, 2005). Efek sosial ini sangat beragam mulai dari efek di bidang akademik, hubungan sosial, keuangan, dan pekerjaan. Apabila tidak ditangani secara serius akan membuat individu lebih menyukai dunia maya dibanding dunia" 3438 3799 W4391260508.pdf 1 0 paratext 0.98654145 ORIGINAL RESEARCH ARTICLE Open Access 0 37 W2751812234.pdf 0 1 separator 0.9572342 ¶ 37 39 W2751812234.pdf 0 2 title 0.9899693 "Illicit Drug Use Among Gym-Goers: a Cross- sectional Study of Gym-Goers in Sweden" 39 123 W2751812234.pdf 0 3 separator 0.9682913 ¶ 123 125 W2751812234.pdf 0 4 contact 0.6786944 Yasmina Molero1,2*, Ann-Sofie Bakshi1and Johanna Gripenberg1 125 186 W2751812234.pdf 0 5 separator 0.9889256 ¶ 186 188 W2751812234.pdf 0 6 title 0.94711745 Abstract 188 197 W2751812234.pdf 0 7 separator 0.99325454 ¶ 197 199 W2751812234.pdf 0 8 text 0.9991661 "Background: The use of anabolic-androgenic steroids has increased among gym-goers, and it has been proposed that this may be part of a polysubstance use pattern that includes the use of illicit drugs. Still, epidemiological data on illicit drug use among gym-goers of both genders are meager. The aim of the present study was thus to examine the use of illicit drugs and its correlates in a large sample of men and women who engaged in weight training at gyms across Sweden." 199 682 W2751812234.pdf 0 9 separator 0.9662908 ¶ 682 684 W2751812234.pdf 0 10 text 0.9991007 "Methods: In this cross-sectional study, a total of 1969 gym-goers who engaged in weight training in 54 gyms across Sweden were invited to fill in a questionnaire. The questionnaire included 25 items on background variables, weight training frequency, use of illicit drugs and doping substances, and non-medical use of benzodiazepines." 684 1023 W2751812234.pdf 0 11 separator 0.9849453 ¶ 1023 1025 W2751812234.pdf 0 12 text 0.9995938 "Results: Of the gym-goers, 19.6% reported having ever used illicit drugs, 6.5% reported use during the past 12 months, and 2.1% during the past 30 days. The most commonly used drug was cannabis, followed by cocaine, amphetamine, and ecstasy. Almost 40% of those who reported drug use had used more than one drug. Male participants and participants between 20 and 39 years of age made up the majority of users. Furthermore, 5.1% of the reported drug users had ever used a doping substance. There was an almost threefold higher odds (OR = 2.99, 95% CI = 1.16 –7.66, p< 0.023) of doping use among people who had reported drug use as compared to non-users." 1025 1688 W2751812234.pdf 0 13 separator 0.98204833 ¶ 1688 1690 W2751812234.pdf 0 14 text 0.9991679 "Conclusions: Training at gyms is typically considered a health-promoting behavior. However, our results revealed a slightly higher prevalence of illicit drug use among gym attendees as compared to the general population. Our findings may have captured an underrecognized group of young adult males who engage in weightlifting and use illicit drugs recreationally and/or as training aids. Developing knowledge is imperative in orientating preventive efforts among at-risk gym-goers." 1690 2180 W2751812234.pdf 0 15 separator 0.9336012 ¶ 2180 2182 W2751812234.pdf 0 16 text 0.45923153 2182 2183 W2751812234.pdf 0 17 paratext 0.47496974 Trial 2183 2188 W2751812234.pdf 0 18 text 0.6381324 Registration: ISRCTN11655041 2188 2217 W2751812234.pdf 0 19 separator 0.9883516 ¶ 2217 2219 W2751812234.pdf 0 20 paratext 0.32640457 Keywords 2219 2228 W2751812234.pdf 0 21 title 0.36571595 : 2228 2229 W2751812234.pdf 0 22 text 0.3033892 Illic 2229 2235 W2751812234.pdf 0 23 title 0.3157375 it 2235 2237 W2751812234.pdf 0 24 text 0.3284557 drug use, Gym-goers, Anabolic 2237 2267 W2751812234.pdf 0 25 title 0.299842 -androgenic 2267 2278 W2751812234.pdf 0 26 text 0.29137498 steroid 2278 2286 W2751812234.pdf 0 27 title 0.28623345 s 2286 2287 W2751812234.pdf 0 28 text 0.30514866 , Cross-section 2287 2302 W2751812234.pdf 0 29 title 0.2917398 al 2302 2304 W2751812234.pdf 0 30 text 0.29533428 study 2304 2310 W2751812234.pdf 0 31 title 0.32679418 , 2310 2311 W2751812234.pdf 0 32 text 0.31810582 Drug 2311 2316 W2751812234.pdf 0 33 title 0.2939227 prevalence 2316 2327 W2751812234.pdf 0 34 separator 0.9948319 ¶ 2327 2329 W2751812234.pdf 0 35 title 0.9837023 Key Points 2329 2340 W2751812234.pdf 0 36 separator 0.98442054 ¶ 2340 2342 W2751812234.pdf 0 37 text 0.99668086 "/C15Approximately one in five gym-goers report use of illicit drugs, most commonly cannabis and stimulants. The rates of drug use are higher among young adult males. /C15Illicit drug use appears to be associated with the use of doping substances./C15Gyms could provide an innovative setting for intervention and prevention efforts targeting doping and illicit drug use, because such establishments already deal with health promotion." 2342 2792 W2751812234.pdf 0 38 separator 0.996777 ¶ 2792 2794 W2751812234.pdf 0 39 title 0.91785264 Background 2794 2805 W2751812234.pdf 0 40 separator 0.99074364 ¶ 2805 2807 W2751812234.pdf 0 41 text 0.9992551 "Research shows that 65% of citizens in the European Union exercise at least once a week. Among this group, 30% exercise at sport clubs such as gyms and fitness centers [1]. In the USA, approximately 21% of adults re- ported exercising regularly [2], and more than 55 million memberships were purchased at health clubs and fitness centers in 2015 [3]. Exercise is a health-promoting activ- ity associated with several benefits, including reduced*" 2807 3267 W2751812234.pdf 0 42 contact 0.99596226 Correspondence: yasmina.molero.samuelson@ki.se 3267 3314 W2751812234.pdf 0 43 separator 0.8601154 ¶ 3314 3316 W2751812234.pdf 0 44 contact 0.99163884 "1STAD, Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, & Stockholm Health Care Services, Stockholm County Council, Norra Stationsgatan 69, SE-1113-64 Stockholm, Sweden 2Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden" 3316 3632 W2751812234.pdf 0 45 separator 0.51409024 ¶ 3632 3634 W2751812234.pdf 0 46 paratext 0.96851724 "© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Molero et al. Sports Medicine - Open (2017) 3:31 DOI 10.1186/s40798-017-0098-8" 3634 4149 W2751812234.pdf 0 0 paratext 0.95158976 CORRECTION OPEN 0 15 W4386540465.pdf 0 1 separator 0.9708574 ¶ 15 17 W4386540465.pdf 0 2 title 0.94608104 "Correction: Time-restricted eating with calorie restriction on weight loss and cardiometabolic risk: a systematic review and meta-analysis" 17 160 W4386540465.pdf 0 3 separator 0.9941001 ¶ 160 162 W4386540465.pdf 0 4 bibliography 0.7821274 Jing-Chao Sun, Zhen-Tao Tan, Chao-Jie He, Hui-Lin Hu, Chang-Lin Zhai and Gang Qian 162 245 W4386540465.pdf 0 5 separator 0.71574974 ¶ © 245 249 W4386540465.pdf 0 6 paratext 0.8649852 The Author(s) 2023 249 268 W4386540465.pdf 0 7 separator 0.93516773 ¶ 268 270 W4386540465.pdf 0 8 paratext 0.972657 European Journal of Clinical Nutrition (2023) 77:1100; https://doi.org/10.1038/s41430-023-01341-4 270 368 W4386540465.pdf 0 9 separator 0.49231082 368 369 W4386540465.pdf 0 10 paratext 0.91245604 "¶ Correction to: European Journal of Clinical Nutrition https://doi.org/ 10.1038/s41430-023-01311-w , published online 24 July 2023" 369 502 W4386540465.pdf 0 11 separator 0.9888342 ¶ 502 504 W4386540465.pdf 0 12 text 0.6496126 In the original article, the 504 534 W4386540465.pdf 0 13 paratext 0.43090084 funding 534 541 W4386540465.pdf 0 14 text 0.6916316 "grant number ‘LGF21H020006 ’ was given incorrectly as ‘LGF21H090017 ’. The original article has been corrected" 541 656 W4386540465.pdf 0 15 paratext 0.89962167 ".Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation,distribution and reproduction in any medium or format, as long as you give appropriatecredit to the original author(s) and the source, provide a link to the Creative Commonslicense, and indicate if changes were made. The images or other third party material in this article are included in the article ’s Creative Commons license, unless indicated" 656 1148 W4386540465.pdf 0 16 text 0.43705758 1148 1149 W4386540465.pdf 0 17 paratext 0.8483036 "¶ otherwise in a credit line to the material. If material is not included in the article ’s Creative Commons license and your intended use is not permitted by statutoryregulation or exceeds the permitted use, you will need to obtain permission directlyfrom the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/ ." 1149 1516 W4386540465.pdf 0 18 separator 0.888158 ¶ 1516 1518 W4386540465.pdf 0 19 paratext 0.9454096 "© The Author(s) 2023 Published online: 8 September 2023www.nature.com/ejcn European Journal of Clinical Nutrition1234567890();,:" 1518 1649 W4386540465.pdf 0 0 paratext 0.95057106 J Clin Exp Dent. 2020;12(1):e98-102. Cancer related with dental rehabilitatione98Journal section: Oral Medicine and Pathology 0 309 W4247125519.pdf 0 1 separator 0.90714496 ¶ 331 333 W4247125519.pdf 0 2 title 0.94295573 Publication Types: Case Report 333 364 W4247125519.pdf 0 3 separator 0.9646768 ¶ 364 366 W4247125519.pdf 0 4 title 0.96617746 Squamous cell carcinoma related with dental implants. A clinical cases report 366 444 W4247125519.pdf 0 5 separator 0.9885988 ¶ 444 446 W4247125519.pdf 0 6 bibliography 0.73587894 "Francisco Granados, Leonor Santos-Ruiz, Marian Contreras, Jose Mellado, Gregorio Martin, Lucas Bermudo, Francisco Ruiz, Yolanda Aguilar, Ignacio Yáñe" 446 599 W4247125519.pdf 0 7 contact 0.5048542 z 599 600 W4247125519.pdf 0 8 separator 0.6147889 ¶ 600 602 W4247125519.pdf 0 9 contact 0.98132026 "University General Hospital of Málaga. Plaza de Hospital Civil, Málaga Correspondence: University General Hospital of Málaga Plaza de Hospital Civil, Málaga, 29009 dr.granados@gmail.com" 602 796 W4247125519.pdf 0 10 separator 0.8831747 ¶ 796 798 W4247125519.pdf 0 11 paratext 0.9612727 "Received: 05/06/2019 Accepted: 07/10/2019" 798 842 W4247125519.pdf 0 12 separator 0.99330956 ¶ 842 844 W4247125519.pdf 0 13 title 0.93575317 Abstract 844 853 W4247125519.pdf 0 14 separator 0.99367833 ¶ 854 856 W4247125519.pdf 0 15 text 0.99957633 "One third of all cases of head and neck carcinoma (CA) concern the oral mucosa. The use of dental implants (DI) for dental rehabilitation is widely extended. However, a few studies have reported some cases with neoplasic al - terations, among the tissue surrounding implants. Our aim was to analyze possible alterations at the bone-implant interface in patients with oral squamous cell carcinoma (SCC), providing new evidence that could relate or discard a possible link between these factors. We used, for the first time, different techniques, including electron microsco - py and histology, to analyze the implant ́s surface and the surrounding tissue from four clinical cases with neoplasic alterations surrounding DI. Histologically, ample inflammatory tissue was found in direct contact with the implant surface. Surface analysis of this tissue, revealed titanium percentages. According to our study, no oncological rela - tion with deterioration of the implant surface was found, although DI were constantly related with peri-implantitis, a chronic trauma of the oral mucosa that could involve a neoplastic factor." 856 2001 W4247125519.pdf 0 16 separator 0.99047786 ¶ 2002 2004 W4247125519.pdf 0 17 paratext 0.95585084 "Key words: Dental implants, carcinoma, peri-implantitis.doi:10.4317/jced. 55964 https://doi.org/10.4317/jced.55964" 2004 2121 W4247125519.pdf 0 18 separator 0.99493265 ¶ 2121 2123 W4247125519.pdf 0 19 title 0.949631 Introduction 2123 2136 W4247125519.pdf 0 20 separator 0.99335766 ¶ 2136 2138 W4247125519.pdf 0 21 text 0.99944705 "Head and neck cancer constitutes 3-5% of all malignan - cies, with 33% appearing over the oral mucosa, repre - senting the most frequent histological type accounting for 90% of all cancers in the oral cavity (1). CA of the oral mucosa mainly affects men from the age of 50 years and is related to chronic tobacco and alcohol consump - tion, risk factors that are time and dose dependent. Ne - vertheless, recent years have seen an increase in this type of cancer among younger patients without these two classical risk factors. Thus, new risk factors are be - ing sought to discover links with the carcinogenesis of SCC of the oral mucosa, such as certain agents that are irritant to the oral mucosa, like poor oral hygiene, poor dentition, ill-fitting dentures and missing teeth with the corresponding dental implants(DI) as mentioned by sin - ghvi et al. and Mendes et al. (2,3)." 2138 3058 W4247125519.pdf 0 22 separator 0.788819 ¶ 3058 3060 W4247125519.pdf 0 23 text 0.98796076 "Since the introduction of DI around 50 years ago (Bra - nemark, 1965), DI have been used as a rehabilitation technique in patients treated for CA of the oral muco -" 3060 3230 W4247125519.pdf 0 24 paratext 0.9678647 Article Number: 55964 http://www.medicinaoral.com/odo/indice.htm 3230 3308 W4247125519.pdf 0 25 separator 0.5969244 ¶ 3308 3310 W4247125519.pdf 0 26 paratext 0.9222943 "© Medicina Oral S. L. C.I.F . B 96689336 - eISSN: 1989-5488 eMail: jced@jced.es Indexed in: Pubmed Pubmed Central® (PMC) Scopus DOI® System" 3310 3463 W4247125519.pdf 0 27 separator 0.99162686 ¶ 3463 3465 W4247125519.pdf 0 28 bibliography 0.99784756 "Granados F, Santos-Ruiz L, Contreras M, Mellado J, Martin G, Bermudo L, Ruiz F, Aguilar Y, Yáñez I. Squamous cell carcinoma related with dental implants. A clinical cases report. J Clin Exp Dent. 2020;12(1):e98-102." 3465 3687 W4247125519.pdf 0 29 separator 0.7660806 ¶ 3687 3689 W4247125519.pdf 0 30 bibliography 0.9917328 http://www.medicinaoral.com/odo/volumenes/v12i1/jcedv12i1p98.pdf 3689 3754 W4247125519.pdf 0 0 paratext 0.95034164 "¶ 250 | Advanced Pharmaceutical Bulletin, 2016, 6(2), 243 -250" 1 70 W2467806903.pdf 7 1 separator 0.9807285 ¶ 71 73 W2467806903.pdf 7 2 bibliography 0.99752843 "Polymeropoulos et al. disease in smokers: Vitamin C restores coronary microcirculatory function. Circulation 2000;102(11):1233 -8. doi: 10.1161/01.cir.102.11.1233" 73 251 W2467806903.pdf 7 3 separator 0.9804325 ¶ 253 255 W2467806903.pdf 7 4 bibliography 0.997979 "51. Solzbach U, Hornig B, Jeserich M, Just H. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation 1997;96( 5):1513 -9. doi: 10.1161/01.cir.96.5.1513" 255 475 W2467806903.pdf 7 5 separator 0.98023653 ¶ 477 479 W2467806903.pdf 7 6 bibliography 0.9974211 "52. Shiroshita -Takeshita A, Schram G, Lavoie J, Nattel S. Effect of simvastatin and antioxidant vitamins on atrial fibrillation promotion by atrial -tachycardia remodeling in dogs. Circulation 2004;110(16):2313 - 9. do i: 10.1161/01.CIR.0000145163.56529.D1" 479 749 W2467806903.pdf 7 7 separator 0.9819695 ¶ 751 753 W2467806903.pdf 7 8 bibliography 0.9979196 "53. Imazio M, Brucato A, Ferrazzi P, Pullara A, Adler Y, Barosi A, et al. Colchicine for Prevention of Postpericardiotomy Syndrome and postoperative atrial fibrillation: The COPPS -2 randomized clinical trial. JAMA 2014 ;312(10):1016 -23. doi: 10.1001/jama.2014.11026" 753 1037 W2467806903.pdf 7 9 separator 0.9736272 ¶ 1039 1041 W2467806903.pdf 7 10 bibliography 0.997382 "54. Imazio M, Brucato A, Ferrazzi P, Rovere ME, Gandino A, Cemin R, et al. Colchicine reduces postoperative atrial fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy. Circulation 2011;124(21):2290 - 5. doi: 10.1161/CIRCULATIONAHA.111.026153" 1041 1377 W2467806903.pdf 7 11 separator 0.9802654 ¶ 1379 1381 W2467806903.pdf 7 12 bibliography 0.9977711 "55. Jacob KA, Nathoe HM, Dieleman JM, van Osch D, Kluin J, van Dijk D. Inflammation in new -onset atrial fibrillation after cardiac surgery: A syst ematic review. Eur J Clin Invest 2014;44(4):402 -28. doi: 10.1111/eci.12237" 1381 1618 W2467806903.pdf 7 13 separator 0.9741209 ¶ 1620 1622 W2467806903.pdf 7 14 bibliography 0.9979239 "56. Ramlawi B, Otu H, Mieno S, Boodhwani M, Sodha NR, Clements RT, et al. Oxidative stress and atrial fibrillation after cardiac surgery: A case -control study. Ann Thorac Surg 2007; 84(4):1166 -72; discussion 72 -3. doi: 10.1016/j.athoracsur.2007.04.126" 1622 1893 W2467806903.pdf 7 15 separator 0.9733639 ¶ 1895 1897 W2467806903.pdf 7 16 bibliography 0.9980146 "57. Buettner GR, Moseley PL. EPR spin trapping of free radicals produced by bleomycin and ascorbate. Free Radic Res Commun 1993;19 Suppl 1:S89 -93. doi: 10.3109/10715769309056s89" 1897 2086 W2467806903.pdf 7 17 separator 0.97106725 ¶ 2088 2090 W2467806903.pdf 7 18 bibliography 0.9978824 "58. Pada yatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, et al. Vitamin C as an antioxidant: Evaluation of its role in disease prevention. J Am Coll Nutr 2003;22(1):18 -35. doi: 10.1080/07315724.2003.10719272" 2090 2313 W2467806903.pdf 7 19 separator 0.99193573 ¶ 2315 2317 W2467806903.pdf 7 0 bibliography 0.99653554 "______. O emprego na globalização: a nova divisão internacional do trabalho e os caminhos que o Brasil escolheu. São Paulo: Boitempo Editorial, 2001. (Mundo do Trabalho)." 0 176 W2810344446.pdf 17 1 separator 0.97468656 ¶ 178 180 W2810344446.pdf 17 2 bibliography 0.9971455 "______. O fenômeno do desemprego no Brasil: diagnóstico e perspectivas. Campinas: [s.n.], 1999a." 180 280 W2810344446.pdf 17 3 separator 0.9217031 ¶ 282 284 W2810344446.pdf 17 4 bibliography 0.9946559 ______. Os velhos e novos problemas do mercado de trabalho brasileiro nos anos 90. 284 367 W2810344446.pdf 17 5 separator 0.97557026 ¶ 368 370 W2810344446.pdf 17 6 bibliography 0.9980024 "LACERDA, Antônio Correia de (Org.). (Des)emprego e globalização: avaliação e perspectivas. São Paulo: EDUC, 1998d. p. 42-65. (Cadernos PUC Economia,7)" 370 524 W2810344446.pdf 17 7 separator 0.9766224 ¶ 526 528 W2810344446.pdf 17 8 bibliography 0.99779576 "POSTHUMA, A. C.; LEITE, M. P. Reestruturação produtiva e qualificação: reflexões sobre a experiência brasileira. In: ENCONTRO NACIONAL DE ESTUDOS DO TRABALHO, 4, 1995, São Paulo. Anais... Rio de Janeiro, 1995, p.403-436." 528 755 W2810344446.pdf 17 9 separator 0.97065806 "¶ ¶ ¶" 757 775 W2810344446.pdf 17 10 text 0.75906247 "[1] Este artigo é fruto da minha tese de doutorado, produzida no Programa de Pós- Graduação em Ciências Sociais, na linha de pesquisa “Trabalho, Subjetividade e Condições de Vida”." 775 962 W2810344446.pdf 17 11 separator 0.9884623 ¶ 965 967 W2810344446.pdf 17 12 contact 0.8004401 "[2] Professora Assistente do Departamento de Educação I da Faculdade de Educação da Universidade Federal da Bahia." 967 1085 W2810344446.pdf 17 13 separator 0.9620991 ¶ 1087 1089 W2810344446.pdf 17 14 text 0.97966063 "[3] O Consenso de Washington é hoje um conjunto, abrangente, de regras de condicionalidade aplicadas de forma cada vez mais padronizada aos diversos países e regiões do mundo, para obter o apoio político e econômico dos governos centrais e dos organismos internacionais. Trata-se também de políticas macroeconômicas de estabilização acompanhadas de reformas estruturais liberalizantes." 1089 1487 W2810344446.pdf 17 15 separator 0.8535867 ¶ 1489 1491 W2810344446.pdf 17 16 text 0.94534475 "[4] Merecem destaque os textos de Elenice Leite: Questões Críticas da Educação Brasileira e Educação Profissional: um projeto para o desenvolvimento sustentado, 1995; PLANFOR: trabalho e empregabilidade; PLANFOR: formando o cidadão produtivo; Sistema Público de Emprego e Educação Profissional: implementação de uma política integrada; Educação Profissional no Brasil: construindo uma nova institucionalidade. E também os do Ministério do Trabalho: PLANFOR: termos de referência dos projetos especiais e PLANFOR: termos de referência dos programas de educação profissional, de 1996." 1491 2095 W2810344446.pdf 17 17 bibliography 0.6183338 PLANFOR: avanço 2095 2111 W2810344446.pdf 17 18 text 0.5898423 conceitual/ 2111 2123 W2810344446.pdf 17 19 bibliography 0.7666791 "termos de referência, 1996; PALNFOR 1996/99: avanço gerencial, 1997." 2123 2194 W2810344446.pdf 17 20 separator 0.9170927 ¶ 2198 2200 W2810344446.pdf 17 21 bibliography 0.98010874 [5] Cf. www.mtb.gov.br/sppe/caged/esta/2000/est1200/tab1.htm 2200 2261 W2810344446.pdf 17 22 separator 0.7393494 "¶ ¶" 2263 2275 W2810344446.pdf 17 23 paratext 0.98697066 volta Página 18 de 19 2275 2297 W2810344446.pdf 17 24 title 0.7190685 O PLANO DE QUALIFICAÇÃO PROFISSIONAL DO TRABALHADOR 2297 2349 W2810344446.pdf 17 25 separator 0.9670564 ¶ 2349 2351 W2810344446.pdf 17 26 paratext 0.96032435 11/9/2008 file://C:\Documents and Settings\Administrador\Meus documentos\Minhas Webs\NED... 2351 2443 W2810344446.pdf 17 0 paratext 0.9894474 E.R. Grela et al. 239 0 21 W2170343059.pdf 3 1 separator 0.9878147 ¶ 21 23 W2170343059.pdf 3 2 math 0.52351636 temperature: 160°C; 23 44 W2170343059.pdf 3 3 text 0.2864065 detector 44 52 W2170343059.pdf 3 4 math 0.5911339 "temperature: 160°C; other gases: hydrogen and oxygen." 52 109 W2170343059.pdf 3 5 separator 0.98284084 ¶ 109 111 W2170343059.pdf 3 6 text 0.9877773 "Lipid quality indices, i.e. the atherogenicity index (AI) and thrombogenicity index (TI), were calculated according to the Ulbricht and Southgate (1991) equations:" 111 284 W2170343059.pdf 3 7 separator 0.8033029 ¶ 284 286 W2170343059.pdf 3 8 math 0.95348835 "AI = [(4 × C14:0) + C16:0] / [n-6PUFA + n-3 PUFA + MUFA] TI = [C14:0 + C16:0 + C18:0] / [(0.5× MUFA) + (0.5 × n-6PUFA) + (3 × n-3PUFA) + n-3/n-6 UFA]." 286 471 W2170343059.pdf 3 9 separator 0.98240864 ¶ 471 473 W2170343059.pdf 3 10 text 0.9904749 "The hypocholesterolaemic/hypercholesterolae - mic ratio (h/H) was obtained according to Fernán - dez et al. (2007):" 473 593 W2170343059.pdf 3 11 math 0.43193668 593 594 W2170343059.pdf 3 12 separator 0.4286254 ¶ 594 595 W2170343059.pdf 3 13 math 0.8848476 "h/H = (C18:1 + C18:2 + C18:3 + C20:3 +C20:4+ C20:5 + C22:4 + C22:5 + C22:6) / (C14:0 + C16:0)." 595 693 W2170343059.pdf 3 14 separator 0.98340315 ¶ 693 695 W2170343059.pdf 3 15 text 0.99738437 "Extracted egg fat was assayed for total cho - lesterol content by the Washburn and Nix method (1974). Homogenates from egg yolks were also ana - lysed for lipid peroxidation products, i.e. lipid per - oxide content according to Gay and Gebicki (2002) and malondialdehyde according to Botsoglou et al. (1994). Malondialdehyde was determined based on the reaction of thiobarbituric acid (TBA) with lipid peroxidation end products in an acid environment and increased temperature to generate a coloured adduct. To eliminate quantities of complex series of adducts from TBA, the assay is run in the presence of inhibitors, e.g., BHT." 695 1359 W2170343059.pdf 3 16 separator 0.9798244 ¶ 1359 1361 W2170343059.pdf 3 17 text 0.99915355 "The activity of an antioxidative enzyme, super - oxide dismutase (SOD), was determined spectro - photometrically in extracted eggs using the adrena - line method (according to Misra, in: Greenwald, 1985) with a modification in wavelength, i.e. at 320 nm. This method was modified to achieve greater selectivity of intermediate reaction products at this wavelength. SOD activity was determined measur - ing the rate of auto-oxidation of adrenaline at 30°C on the basis of the increase of absorbance at 320 nm (which corresponds to monitoring the increase in the concentration of various products of adrenaline oxidation). The activity of catalase (CAT) was de - termined according to Claiborne (1985). The assay consisted of measuring the substrate (hydrogen per - oxide) decomposition rate catalysed by this enzyme." 1361 2217 W2170343059.pdf 3 18 separator 0.99658954 ¶ 2217 2219 W2170343059.pdf 3 19 title 0.99207765 Statistical analysis 2219 2240 W2170343059.pdf 3 20 separator 0.99549234 ¶ 2240 2242 W2170343059.pdf 3 21 text 0.9890627 "Statistical computations were carried out using STATISTICA Ver 5.1.G software (1996). For all analysed dependent variables, one-way analysis of variance, ANOV A, was conducted according to the following model: " 2242 2462 W2170343059.pdf 3 22 separator 0.4220948 ¶ 2462 2463 W2170343059.pdf 3 23 text 0.6891825 yij = μ + 2463 2474 W2170343059.pdf 3 24 math 0.51713437 αi 2474 2476 W2170343059.pdf 3 25 text 0.50345033 + 2476 2478 W2170343059.pdf 3 26 math 0.5317813 eij 2478 2482 W2170343059.pdf 3 27 text 0.71477073 "¶ where: μ – total mean, αi – stable effect of i-th addi - tive for i = 0, 1, 2, 3 (for control i = 0), eij– random error has normal distribution N (0,2σ)." 2482 2643 W2170343059.pdf 3 28 separator 0.9957594 ¶ 2643 2645 W2170343059.pdf 3 29 title 0.9484629 Results 2645 2653 W2170343059.pdf 3 30 separator 0.99568844 ¶ 2653 2655 W2170343059.pdf 3 31 text 0.999327 "Average egg production (EP) during the study equalled 92%. No significant differences between groups or terms of study were found (Table 3). The physicochemical parameters of eggs (Table 3) indi - cated that the addition of 1.5% and 3.0% LPC to the hen feeds had no effect on the quality traits of the eggs. In turn, the study demonstrated a significant increase in the yolk colour intensity of eggs laid by hens receiving feed mixtures with 1.5% and 3.0% LPC, i.e. increases by 1.57 pts (D-1) and 1.2 pts (D-2), respectively, compared with the control group, in which egg yolk colour was assessed at 7.06 pts in the La’Roche’s scale." 2655 3326 W2170343059.pdf 3 32 separator 0.9759009 ¶ 3327 3329 W2170343059.pdf 3 33 text 0.9991743 "The analysis of egg yolks (Table 4) did not reveal any significant effect of LPC on their fat and cholesterol contents. The supplement also did not significantly influence the fatty acid profile of egg yolks, with exception of a increased n-6 PUFA content. This increase resulted in a higher (P ≤ 0.05) n-6/n-3 ratio in comparison with the control (Table 5)." 3329 3707 W2170343059.pdf 3 34 separator 0.88951486 ¶ 3708 3710 W2170343059.pdf 3 35 text 0.9987056 "These dependencies were observed in the yolk fat of eggs collected both in week 33 as well as in week 53 of rearing." 3710 3833 W2170343059.pdf 3 36 separator 0.97597086 ¶ 3833 3835 W2170343059.pdf 3 37 text 0.99944067 "Analysis of the mean level of H2O2 demon - strated its significant increase in yolks of eggs from hens fed mixtures containing both 1.5% and 3.0% LPC. In eggs from group D-1 (1.5% LPC), the con - centration of H2O2 increased by 24%, whereas in those from group D-2 (3.0% LPC), by as much as 35%, compared with control eggs (Table 6). This correlation was observed in egg yolks collected both in week 33 and week 53 of life. The eggs of the laying hens fed the diets enriched both with 1.5% or 3.0% LPC were, additionally, character - istic because of their significantly higher level of the end product of lipid peroxidation, i.e. malon - dialdehyde (MDA): by 35% in group D-1 and by 50% in group D-2 in comparison with the control." 3835 4606 W2170343059.pdf 3 38 separator 0.6211818 ¶ 4607 4609 W2170343059.pdf 3 39 text 0.99854636 "These eggs also showed considerable ( P ≤ 0.05) suppression of catalase activity compared with control eggs (Table 6)." 4609 4734 W2170343059.pdf 3 0 title 0.9632902 3 Formation of Gradient Structure in Rails at Long-Term Operation 0 65 W3107735507.pdf 2 1 separator 0.99647725 ¶ 65 67 W3107735507.pdf 2 2 caption 0.9964946 Figure 2. Structure of rail tread surface; a – unetched metallographic section; b – etched metallographic section. 67 183 W3107735507.pdf 2 3 separator 0.97349775 ¶ 183 185 W3107735507.pdf 2 4 caption 0.99611294 "Figure 3. Electron microscopic images of rail structure in the layer located at a depth of 10 mm; a – lamellar pearlite; b - degenerate pearlite; c – structure-free ferrite." 185 363 W3107735507.pdf 2 5 separator 0.9708476 ¶ 363 365 W3107735507.pdf 2 6 caption 0.99476033 "Figure 4. Structure of rail metal; a - fractured lamellar pearlite; b - ferrite-carbide mixture; a - layer at a depth of 2 mm; b - surface layer of fillet." 365 525 W3107735507.pdf 2 7 separator 0.9815055 ¶ 525 527 W3107735507.pdf 2 8 caption 0.9917617 "Figure 5. Electron microscopic images of ‘ferrite-carbide mixture’ structure of surface layer. Arrows indicate in (b) the particles of carbide phase." 527 681 W3107735507.pdf 2 0 paratext 0.86799455 Pérez-Ortega et al. 0 19 W2601087101.pdf 4 1 title 0.9694967 Interactions in Meningococcal Biofilms 19 57 W2601087101.pdf 4 2 separator 0.9811332 ¶ 57 59 W2601087101.pdf 4 3 text 0.99954396 "processingprogramImageJ.Theresultsrevealedlargedifferenc es in fluorescence intensity between the promoter variants in th e orderopaBPH>opaBPM>opaBPL,inaccordancewithprotein production levels detected on Western blots (Figure S1D). Th e fluorescence of pIN H-derived transformants was visualized in all our imaging devices and allowed for the discrimination o f fluorescentstrainsinmixedbiofilms.Therefore,thisplasmi dwas used to generate fluorescent bacteria. Indeed, we could gene rate fluorescent bacteria in strains of Nm,Nl,andNgtransformed withthisplasmid(FigureS1E)." 59 644 W2601087101.pdf 4 4 separator 0.99636847 ¶ 644 646 W2601087101.pdf 4 5 title 0.9931609 Biofilm Structure of Fluorescent Neisseriae 646 689 W2601087101.pdf 4 6 separator 0.9915583 ¶ 689 691 W2601087101.pdf 4 7 text 0.99953014 "To study the biofilm structure of various NmandNlstrains, biofilms of fluorescent bacteria were formed on glass and visualized by confocal microscopy. All strains used were caps ule deficient, as capsule has been reported to inhibit biofilm formation on abiotic surfaces ( Yi et al., 2004; Lappann et al., 2006).Figure1A shows the structures of 15-h old biofilms of various strains. Biofilms consisted of cell clusters, but the size, dispersion and number of the clusters differed largely between both species and between strains of the same species." 691 1250 W2601087101.pdf 4 8 separator 0.9226787 ¶ 1250 1252 W2601087101.pdf 4 9 text 0.999722 "Nmstrains generally formed smaller clusters than did the Nl strains. Also, Nmstrains of cc8 and cc11 formed much smaller and less compact clusters with, together, a larger coverage o f the substratum than strains of cc32 and cc53 ( Figure1A ). It is noteworthy that strains of cc8 and cc11 use an eDNA- independent strategy of biofilm formation in contrast to stra ins ofothercc( Lappannetal.,2010 ).BothNlstrainsformedbiofilms that were sensitive to DNase I (data not shown). Thus, these results confirmed that aggregation is a common feature durin g neisserialbiofilmformation." 1252 1846 W2601087101.pdf 4 10 separator 0.99610996 ¶ 1846 1848 W2601087101.pdf 4 11 title 0.99114424 "eDNA-Binding Proteins Contribute to Cell Aggregation in Single-Strain Biofilms" 1848 1928 W2601087101.pdf 4 12 separator 0.98580444 ¶ 1928 1930 W2601087101.pdf 4 13 text 0.9996788 "AutA and type IV pili are known to be involved in bacterial aggregation during biofilm formation ( Lappann et al., 2006; Arenas et al., 2015a ). Here, we explored the contribution in this process of eDNA-binding proteins, which are cleaved from the cell surface by the protease NalP. Figure1B shows the biofilm structure of mutants of Nmstrains HB-1 and BB- 1 lacking nalP. ThenalPmutants formed bigger and more compact microcolonies than the corresponding wild types (Figure1A ), although the difference was less pronounced in BB-1, in accordance with the eDNA-independent strategy of biofilmformationofthisstrain.Thestrongeraggregationo fHB- 1/Delta1nalPis not due to increased piliation, as Western blotting assays showed a similar production of PilE, the major pilus subunit, in the wild type and the nalPmutant (Figure S2A)." 1930 2782 W2601087101.pdf 4 14 separator 0.9518136 ¶ 2782 2784 W2601087101.pdf 4 15 text 0.99970955 "Since cc11 strain BB-1 produces a different type of pilin that is not recognized by the antibodies ( Cehovin et al., 2010 ) we could not verify pilEexpression in this strain and its nalPmutant." 2784 2981 W2601087101.pdf 4 16 separator 0.91278297 ¶ 2981 2983 W2601087101.pdf 4 17 text 0.9997423 "TheautAgene is disrupted in HB-1 and BB-1 because of the presence of a premature stop codon ( Arenas et al., 2015a ) and can,therefore,notplayaroleinthedifferencesbetweentheNa lP- producingandnon-producingstrains.Furthermore,aggregat ion was severely reduced when NalP was expressed in transfrom plasmidpEN300inthe nalPmutants( Figure1B )demonstratingthat the increased aggregation of the nalPmutants is a direct effect of the lack of NalP synthesis. Microscopic examination of log-phase precultures grown under shaking conditions showed the presence of only few very small aggregates in the nalP mutant of HB-1 but not in the wild type (Figure S2B). The size of these aggregates does not match those observed in biofilms (Figure S2B). Probably, the abundance of eDNA at the surface of the nalPmutant cells facilitates aggregation and thereby microcolony formation. Such interactions may occu r already in liquid cultures, but they are disrupted by physical forces during shaking. In conclusion, these results show th at microcolony formation occurs during biofilm formation and thatnalPexpression influences this process, presumably by cleaving eDNA-binding proteins from the cell surface. Thus, these data expand the previously established role of NalP duri ng theinitiationofbiofilmformationbydemonstratingitseffect on biofilmstructuring." 2983 4359 W2601087101.pdf 4 18 separator 0.9962409 ¶ 4359 4361 W2601087101.pdf 4 19 title 0.9930352 "Interbacterial Interactions in Dual-Strain Biofilms" 4361 4414 W2601087101.pdf 4 20 separator 0.9940359 ¶ 4414 4416 W2601087101.pdf 4 21 text 0.9997312 "The high rates of Nmcolonization ( Sim et al., 2000 ) suggest an intense traffic of strains within the nasopharynx. Consequent ly, strains could interact with each other to compete or to benefit during colonization. To study how different strains affect each other during biofilm formation, we analyzed pairwise combinations of three Nmstrains in biofilm experiments. We selected strains HB-1, BB-1, and α14 because different traits relevant for biofilm formation. HB-1 and BB-1 were chosen as representatives of strains following an eDNA-dependent and -independent strategy of biofilm formation, respectively (Arenas et al., 2013a ). Strain α14 was chosen because it producesAutA,whichcausesautoaggregationandtherebyaffec ts biofilm architecture ( Arenas et al., 2015a ). HB-1 and BB-1 do not produce AutA ( Arenas et al., 2015a ). Other relevant characteristicsofthesestrainsarelistedin Table1." 4416 5329 W2601087101.pdf 4 22 separator 0.97482467 ¶ 5329 5331 W2601087101.pdf 4 23 text 0.9981541 "First, several relevant properties of these strains were furt her analyzed. HB-1 and BB-1 clearly showed twitching motility in biofilms ( Videos1,2, respectively, in Supplementary Material). Strain α14, however, showed no twitching motility, similar as apilEmutant of HB-1 ( Videos3,4, respectively, in Supplementary Material). Interestingly, Western blot analy sis revealedaconsiderabledifferenceintheelectrophoreticmob ility of the PilE proteins of HB-1 and α14 (Figure S2A), even though the sequences of these proteins are identical according to th e availablegenomesequences( Schoenetal.,2008;Pietetal.,2011 )." 5331 5962 W2601087101.pdf 4 24 separator 0.90573794 ¶ 5962 5964 W2601087101.pdf 4 25 text 0.99974877 "Additionally,thegenomesequenceof α14showedthat nalPisout ofphase;WesternblottingconfirmedthatNalPisnotsynthesi zed in this strain (Figure S2A). All relevant properties of the thr ee strainsarelistedin Table1." 5964 6178 W2601087101.pdf 4 26 separator 0.97732854 ¶ 6178 6180 W2601087101.pdf 4 27 text 0.9958744 "Each strain was grown independently in TSB, and, after adjusting them to the same OD, they were mixed 1:1 for biofilm formation. First, green- and red-fluorescent variants of st rain HB-1 were combined ( Figure2A ). Both variants of the strain formed separate clusters with hardly any intermixing, altho ugh these separate clusters extensively interacted ( Figure2A ). A similar result was observed when green- and red-fluorescent ¶" 6180 6622 W2601087101.pdf 4 28 paratext 0.9851885 Frontiers in Microbiology | www.frontiersin.org 5 March 2017 | Volume 8 | Article 434 6622 6708 W2601087101.pdf 4 0 bibliography 0.59341 "5Only one individual showed possible signs of GSD on the lower neck and two" 0 78 W2897343092.pdf 5 1 text 0.49617392 others 78 85 W2897343092.pdf 5 2 bibliography 0.47419107 showed 85 93 W2897343092.pdf 5 3 text 0.46895915 signs 93 98 W2897343092.pdf 5 4 bibliography 0.40598774 of 98 101 W2897343092.pdf 5 5 text 0.40400174 101 102 W2897343092.pdf 5 6 bibliography 0.4641741 GED, based 102 112 W2897343092.pdf 5 7 text 0.42037404 ¶ 113 115 W2897343092.pdf 5 8 bibliography 0.500157 on gross pathological 115 137 W2897343092.pdf 5 9 text 0.4400776 features 137 146 W2897343092.pdf 5 10 bibliography 0.6304176 described in the literature. 146 175 W2897343092.pdf 5 11 separator 0.9868301 ¶ 176 178 W2897343092.pdf 5 12 text 0.99683046 "These more superficial wounds may not have been perceived as a stressor in these individuals, subsequently resulting in fGCM levels comparable to non-injured individuals." 178 355 W2897343092.pdf 5 13 separator 0.98934555 ¶ 355 357 W2897343092.pdf 5 14 text 0.99943227 "Elevated GC levels in animals with lower BC have been observed in a number of studies on birds and mammals (Kitaysky et al. 1999, Cabezas et al. 2007, Pokharel et al. 2017). When comparing individual baseline levels in two colonies of black-legged kittiwakes Rissa tridactyla for exam - ple, higher levels have been found in the colony living in a food scarce environment compared to food-rich environ - ment (Kitaysky et al. 1999). In a study on Steller sea lions, the loss of body mass was associated with an increase in GC (Jeanniard du Dot et al. 2009). In our study, three individu - als assigned to category 3 not only showed severe foot and leg injuries, but also had a lower BC scoring. The lower BC could be caused due to reduced mobility and subsequent reduced food intake leading to an increase in GC levels, a similar scenario has been described for elephants with foot injuries (Ganswindt et al. 2010). Alternatively, it is also pos - sible that the increased GC levels due to the injuries lead to a reduced BC due to an enhanced energy demand as glu - coneogenesis is activated in stressful situations (Sapolsky 2002). Further studies are needed to entangle which of the two proposed scenarios are responsible for the increased GC, or if it is a combination of reduced energy intake during times of increased energy demands." 357 1758 W2897343092.pdf 5 15 separator 0.99435264 ¶ 1758 1760 W2897343092.pdf 5 16 text 0.9995318 "The severity, but also the duration of an injury can influ - ence the distinctiveness of an adrenal response (Voigtlän - der et al. 2006). This has been shown in elephants suffering from enduring foot injuries, where higher fGCM concen - trations were found in the individual afflicted by the lon - ger lasting injury (Ganswindt et al. 2010). In our study, the individual with the persistent injury (approx. one year, pers. comm.) did not show higher fGCM levels compared to individuals with a short to medium term injury. A pos - sible explanation could be the adaptation of the HPA axis towards a long-term stressor. Although initially helpful to cope with a stressful situation, prolonged elevation of GC levels may cause changes in physiology and behaviour of an individual, which can have deleterious implications for survival and well-being (Herman 2013). The individual may have adapted to the consequences of the injury (e.g. decreased mobility), with a subsequent decrease in GC lev - els over time. Individual differences in GC levels also need to be taken into considerations, as the perceived pain varies between individuals (Bateson 1991)." 1760 2964 W2897343092.pdf 5 17 separator 0.9956274 ¶ 2964 2966 W2897343092.pdf 5 18 text 0.99938285 "In conclusion, we found differences in fGCM concen - trations in individual giraffes assigned to different catego - ries of trauma and body conditions. The possible response observed may result from a combination of differences in the severity of the injuries and the subsequent degree of pain associated with it, the influence of the stress response on the energetic condition, as well as the duration of the injuries." 2966 3402 W2897343092.pdf 5 19 separator 0.98857236 ¶ 3403 3405 W2897343092.pdf 5 20 text 0.99924934 "The results of our study are limited to a small sample size and although the data was collected during the end of the rainy season when food resources can be expected to be adequate, we cannot control for the effects of food access on the body condition of the individuals. A more detailed study over a longer time would be needed to evaluate the individual food intake and the effects that the injuries have on the mobility." 3405 3846 W2897343092.pdf 5 21 separator 0.9903233 ¶ 3846 3848 W2897343092.pdf 5 22 text 0.9990141 "Euthanasia is a common management tool used to pre - vent unnecessary suffering, but especially in wild animals the severity of an injury and the associated pain perceived could be difficult to assess. Combining an assessment of BC and analysis of individual glucocorticoid levels may help to improve health assessments in free-ranging giraffes and thus assist management decisions." 3848 4248 W2897343092.pdf 5 23 separator 0.99596226 ¶ 4248 4250 W2897343092.pdf 5 24 paratext 0.27602565 Acknowledgements – 4250 4269 W2897343092.pdf 5 25 text 0.67106646 "We thank Tal Fineberg for providing access to Mbuluzi Game Reserve and their giraffes and Stefanie Ganswindt for expert help with laboratory techniques." 4270 4429 W2897343092.pdf 5 26 separator 0.94129264 ¶ 4429 4431 W2897343092.pdf 5 27 text 0.6887042 Funding – All Out Africa provided support for this research. 4431 4493 W2897343092.pdf 5 28 separator 0.94481444 ¶ 4493 4495 W2897343092.pdf 5 29 text 0.5946555 Conflicts of interest – The authors declare no conflicts of interest. 4495 4566 W2897343092.pdf 5 30 separator 0.982777 ¶ 4566 4568 W2897343092.pdf 5 31 title 0.77503884 References 4568 4579 W2897343092.pdf 5 32 separator 0.99068284 ¶ 4579 4581 W2897343092.pdf 5 33 bibliography 0.99761796 "Bashaw, M. J. et al. 2016. Non-invasive assessment of adrenocortical activity as a measure of stress in giraffe ( Giraffa camelopardalis ). – BMC Vet. Res. 12: 235." 4581 4752 W2897343092.pdf 5 34 separator 0.9587163 ¶ 4752 4754 W2897343092.pdf 5 35 bibliography 0.99801064 "Bateson, P . 1991. Assessment of pain in animals. – Anim. Behav. 42: 827–839." 4754 4835 W2897343092.pdf 5 36 separator 0.9603503 ¶ 4835 4837 W2897343092.pdf 5 37 bibliography 0.9980377 "Bond, M. L. et al. 2016. Soil correlates and mortality from Giraffe Skin Disease in Tanzania. – J. Wildl. Dis. 52: 953–958." 4837 4964 W2897343092.pdf 5 38 separator 0.96603924 ¶ 4964 4966 W2897343092.pdf 5 39 bibliography 0.9980698 "Boonstra, R. et al. 1998. The impact of predator-induced stress on the snowshoe hare cycle. – Ecol. Monogr. 79: 371–394." 4966 5090 W2897343092.pdf 5 40 separator 0.9601724 ¶ 5090 5092 W2897343092.pdf 5 41 bibliography 0.9980396 "Cabezas, S. et al. 2007. 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Patterns of urinary and fecal steroid excretion during the ovarian cycle and pregnancy in the African elephant (Loxodonta africana ). – Gen. Comp. Endocrinol. 115: 76–89." 5666 5865 W2897343092.pdf 5 48 separator 0.98032653 ¶ 5865 5867 W2897343092.pdf 5 49 bibliography 0.9979054 "Ganswindt, A. et al. 2002. Assessment of testicular endocrine function in captive African elephants by measurement of urinary and fecal androgens. – Zoo Biol. 21: 27–36." 5867 6043 W2897343092.pdf 5 50 separator 0.9768553 ¶ 6043 6045 W2897343092.pdf 5 51 bibliography 0.99759626 "Ganswindt, A. et al. 2005. The sexually active states of free-ranging male African elephants ( Loxodonta africana ): defining musth and non-musth using endocrinology, physical signals, and behaviour. – Horm. Behav. 47: 83–91." 6045 6280 W2897343092.pdf 5 52 separator 0.98126316 ¶ 6280 6282 W2897343092.pdf 5 53 bibliography 0.99775636 "Ganswindt, A. et al. 2010. Concentrations of faecal glucocorticoid metabolites in physically injured free-ranging African elephants Loxodonta africana . – Wildl. Biol. 16: 323–332." 6282 6469 W2897343092.pdf 5 54 separator 0.9785321 ¶ 6469 6471 W2897343092.pdf 5 55 bibliography 0.9980261 "Hardy, M. P . et al. 2005. Stress hormone and male reproductive function. – Cell Tissue Res. 322: 147–153." 6471 6581 W2897343092.pdf 5 56 separator 0.96168065 ¶ 6581 6583 W2897343092.pdf 5 57 bibliography 0.9979369 "Heistermann, M. 2010. Non-invasive monitoring of endocrine status in laboratory primates: methods, guidelines and applications. – Adv. Sci. Res. 5: 1–9." 6583 6742 W2897343092.pdf 5 58 separator 0.9691465 ¶ 6742 6744 W2897343092.pdf 5 59 bibliography 0.9980106 "Hellyer, P . W. 2010. Pain assessment and management. – In: Kahn, C. M. and Line, S. (eds), Merck veterinary manual. A handbook of diagnosis, therapy and disease prevention and control for the veterinarian. Merck and Co. Inc, pp. 1857–1863." 6744 6994 W2897343092.pdf 5 60 separator 0.97876537 ¶ 6994 6996 W2897343092.pdf 5 61 bibliography 0.9979131 "Herman, J. P . 2013. Neural control of chronic stress adaptation. – Front. Behav. Neurosci. 7: 1–12." 6996 7100 W2897343092.pdf 5 62 separator 0.902881 ¶ 7100 7102 W2897343092.pdf 5 63 bibliography 0.9980084 "Holm, S. 1979. A simple sequentially rejective multiple test procedure. – Scand. J. Stat. 6: 65–70." 7102 7205 W2897343092.pdf 5 64 separator 0.9787029 ¶ 7205 7207 W2897343092.pdf 5 65 paratext 0.98398334 Downloaded From: https://bioone.org/journals/Wildlife-Biology on 17 May 2024 7207 7284 W2897343092.pdf 5 66 separator 0.5238541 ¶ 7284 7286 W2897343092.pdf 5 67 paratext 0.9662247 Terms of Use: https://bioone.org/terms-of-use 7286 7332 W2897343092.pdf 5 0 text 0.9851247 "the 22 DM patients, 11 (50%) were diagnosed after pre- senting with MK." 0 73 W2981710942.pdf 3 1 separator 0.99212 ¶ 73 75 W2981710942.pdf 3 2 text 0.69767696 Table 2 shows 75 90 W2981710942.pdf 3 3 title 0.5288631 exposure comparison 90 109 W2981710942.pdf 3 4 text 0.97299784 "among the cases and controls matched for age, sex and village. The proportion of HIV positive patients among the cases was 9% versus 1% among the controls ( p= .0003). DM was 7% among the cases versus 1.4% among the con- trols ( p= .012). Sixty-one (29%) of the cases reportedeye trauma before onset of symptoms, none of the controls reported any trauma in the previous 3 months." 109 501 W2981710942.pdf 3 5 separator 0.7618745 ¶ 501 503 W2981710942.pdf 3 6 text 0.9961833 "One hundred and twenty-eight (61%) of the cases reported having used TEM versus only one control who had recently used TEM. Cases more than controls had more people in the poor social economic bracket (p= .0001) and lived further from the nearest village health centre, median distance 3km (IQR 1 –4, total" 503 820 W2981710942.pdf 3 7 title 0.9747233 Table 1. Comparison of people who were enrolled into the nested case-control and those who were not (n = 313). 820 930 W2981710942.pdf 3 8 separator 0.98014843 ¶ 930 932 W2981710942.pdf 3 9 table 0.9954954 "Enrolled into the case-control (n = 215) Not enrolled (n = 98) ǂ Variable Median (IQR) (Total range) Median (IQR) (Total range) P value Age 50 (37 –60) (18 –96) 42 (33 –59) (18 –87) .040 Distance 78 (53 –120) (1.5 –286) 85 (48 –183) (0.2 –378) .171 Household population 7 (5–8) (1 –28) 6 (3 –8) (1 –18) .030 Distance to nearest Health Centre in KM 3 (1–4) (0 –45) 2 (1 –4) (0 –35) .215 Variable Category count (%) count (%) P value Gender Female 101 (47) 38 (39) .176 Male 114 (53) 60 (61) Occupation Farmer 157 (73) 63 (64) .117 Non-farmer 58 (27) 35 (36) Marital status Not married* 61 (28) 34 (35) .259 Married 154 (72) 64 (65) Education status None 60 (28) 24 (25) .896 Primary 110 (51) 52 (53) Secondary 31 (14) 14 (14) Tertiary 14 (7) 8 (8) Being head of household Yes 146 (68) 66 (67) .922 No 69 (32) 32 (33) Being HIV positive (overall 12%) Ɨ Yes 18 (8%) 19 (22%) .001 No 197 (92%) 67 (78%) Being a Diabetic patient (overall 7%) Ɨ Yes 14 (7%) 8 (9%) .385 No 201 (93%) 77 (91%)" 932 1961 W2981710942.pdf 3 10 separator 0.92563677 ¶ 1961 1963 W2981710942.pdf 3 11 text 0.9832342 "*Not married refers to single, separated, divorced or widowed. Ɨmissing results for HIV and diabetes, it was not possible to test everyone for HIV and Diabetes. ǂThese 98 include the 53 that were lost to follow up and the 45 cases with follow-up data at 3 months but to whom controls could not be enrolled." 1963 2274 W2981710942.pdf 3 12 separator 0.99648094 ¶ 2274 2276 W2981710942.pdf 3 13 title 0.9707238 Table 2. A matched comparison of exposures among 215 case-control pairs. (gender and village and adjusted for age). 2276 2392 W2981710942.pdf 3 14 separator 0.99109 ¶ 2392 2394 W2981710942.pdf 3 15 table 0.9945534 "Cases (215) Controls (215) P-value Exposure n (%) n (%) Married 154 (72) 143 (67) .215 Head of household 146 (68) 140 (65) .441 Education status None 60 (28) 48 (22) .148 Primary 110 (51) 114 (53) Secondary 31 (14) 32 (15) Tertiary 14 (7) 21 (10) Farming occupation (if yes) 157 (73) 168 (78) .144 Trauma (if yes, n = 214) 63 (29) 0 (0) <.0001 Traditional Eye Medicine (if yes) 133 (62) 1 (0.5) <.0001 HIV (being positive) * 18 (9) 2 (1) .0001 Diabetes Mellitus (being positive) Ɨ 14 (7) 3 (1.4) .012 Size of the household Small (1 –4 people) 50 (23) 109 (51) Medium (5 –10 people) 115 (54) 94 (44) Large (>11 people) 50 (23) 12 (5) Self-reported wealth status ǂ Poor 36 (18) 20 (9) .003 Middle 158 (74) 188 (89) Upper 21 (8) 6 (2) Type of water source Well 103 (50) 107 (52) Tap 85 (41) 74 (36) Other 17 (9) 25 (12) median (IQR) median (IQR) Distance to nearest Health centre 3 (1–4) 2 (1–3) <.0001" 2394 3348 W2981710942.pdf 3 16 separator 0.9071965 ¶ 3348 3350 W2981710942.pdf 3 17 text 0.9652656 "*Twelve cases had missing HIV results, however, all the controls had HIV results reported. ƗNineteen Cases had missing Diabetes test results. self-reported wealth status was classified as poor (1 ”very poor ”2”poor ”), middle (3 “neither poor nor rich ”) upper (4 “rich”5“very rich ”)OPHTHALMIC EPIDEMIOLOGY 101" 3350 3664 W2981710942.pdf 3 0 paratext 0.9897073 Page 22/22 0 10 W4383198394.pdf 21 1 separator 0.995798 ¶ 10 12 W4383198394.pdf 21 2 caption 0.8172477 Figure 9 12 21 W4383198394.pdf 21 3 separator 0.96172714 ¶ 21 23 W4383198394.pdf 21 4 caption 0.8074619 Flowchart of adopted methodology 23 56 W4383198394.pdf 21 5 separator 0.9945524 ¶ 56 58 W4383198394.pdf 21 6 title 0.98454547 Supplementary Files 58 78 W4383198394.pdf 21 7 separator 0.9968299 ¶ 78 80 W4383198394.pdf 21 8 text 0.98062354 This is a list of supplementary 80 112 W4383198394.pdf 21 0 paratext 0.9794286 720 Eur J Appl Physiol (2017) 117:713–720 0 41 W2593296096.pdf 7 1 separator 0.6814976 ¶ 41 43 W2593296096.pdf 7 2 paratext 0.9750298 1 3 43 47 W2593296096.pdf 7 3 separator 0.9200443 ¶ 47 49 W2593296096.pdf 7 4 bibliography 0.97442704 "agonist-antagonist EMG, muscle CSA, and force during strength training in middle-aged and older people. 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Proc Natl Acad Sci 80(4):1008–1012" 3046 3292 W2593296096.pdf 7 33 separator 0.9796523 ¶ 3292 3294 W2593296096.pdf 7 34 bibliography 0.9980465 "Patel T, Lieber R (1997) Force transmission in skeletal muscle: from actomyosin to external tendons. Exerc Sport Sci Rev 25:321–363" 3294 3429 W2593296096.pdf 7 35 separator 0.97669053 ¶ 3429 3431 W2593296096.pdf 7 36 bibliography 0.9981056 "Place N, Casartelli N, Glatthorn JF, Maffiuletti NA (2010) Compari- son of quadriceps inactivation between nerve and muscle stimu-lation. Muscle Nerve 42(6):894–900. doi:10.1002/mus.21776" 3431 3621 W2593296096.pdf 7 37 separator 0.97053576 ¶ 3621 3623 W2593296096.pdf 7 38 bibliography 0.9980154 "Quach NL, Rando TA (2006) Focal adhesion kinase is essential for costamerogenesis in cultured skeletal muscle cells. Dev Biol 293(1):38–52" 3623 3765 W2593296096.pdf 7 39 separator 0.9773662 ¶ 3765 3767 W2593296096.pdf 7 40 bibliography 0.9979068 "Ramaswamy KS, Palmer ML, van der Meulen JH, Renoux A, Kostro- minova TY, Michele DE, Faulkner JA (2011) Lateral transmis-sion of force is impaired in skeletal muscles of dystrophic mice and very old rats. J Physiol 589(5):1195–1208. doi:10.1113/ jphysiol.2010.201921" 3767 4038 W2593296096.pdf 7 41 separator 0.98817873 ¶ 4038 4040 W2593296096.pdf 7 42 bibliography 0.997962 "Reeves ND, Narici MV (2003) Behavior of human muscle fascicles during shortening and lengthening contractions in vivo. J Appl Physiol 95(3):1090–1096" 4040 4193 W2593296096.pdf 7 43 separator 0.9745736 ¶ 4193 4195 W2593296096.pdf 7 44 bibliography 0.99796355 "Reeves ND, Maganaris CN, Narici MV (2004a) Ultrasonographic assessment of human skeletal muscle size. 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(2023) 77:350–374 0 35 W4328052409.pdf 10 1 separator 0.9940686 ¶ 35 37 W4328052409.pdf 10 2 table 0.57141393 Table 7 Example for creating the job-specific competence model for the employees of quality control in SME 3 37 145 W4328052409.pdf 10 3 separator 0.99046767 ¶ 145 147 W4328052409.pdf 10 4 table 0.8262174 Tab. 7 Beispiel für die Herleitung des tätigkeitsspezifischen Kompetenzmodells für die Mitarbeitenden der Qualitätskontrolle in KMU 3 147 280 W4328052409.pdf 10 5 separator 0.99559563 ¶ 280 282 W4328052409.pdf 10 6 title 0.9489336 Competence dimensions 282 304 W4328052409.pdf 10 7 separator 0.5131686 ¶ 304 306 W4328052409.pdf 10 8 title 0.5290615 and relating sub-dimen 306 329 W4328052409.pdf 10 9 table 0.66178304 "- sionsExemplary interview text passages (translated from German) Job-" 329 401 W4328052409.pdf 10 10 title 0.47092354 specific competence facets 401 426 W4328052409.pdf 10 11 separator 0.981699 ¶ 426 428 W4328052409.pdf 10 12 title 0.7395627 Professional competence 428 452 W4328052409.pdf 10 13 separator 0.54944056 ¶ 452 454 W4328052409.pdf 10 14 text 0.9722588 "Application of manual skills“Yes, I will take a couple of waffles and measure them. I check the weight, length and diameter. I also check whether the appearance of the product fits.”Measuring the product (e.g., length, di- ameter, weight) and conducting visual inspections" 454 735 W4328052409.pdf 10 15 separator 0.994097 ¶ 735 737 W4328052409.pdf 10 16 title 0.8035647 Personal competence 737 757 W4328052409.pdf 10 17 separator 0.86749756 ¶ 757 759 W4328052409.pdf 10 18 text 0.9949028 "Assuming respons ibility “Y ou also have to be able to d ecide quickly and you have also to be ready to decide whether a produc t can still be pr ocessed.”Responsible decision-making with regard to produc t quality and a kappa value of 0.826 for its second level. The us- ability questionnaires (filled out by the employees as part of the third interview module) were analyzed descriptively using the software SPSS 28. For each usability criteria that is listed in the questionnaire, its mean value and standard deviation were calculated." 759 1313 W4328052409.pdf 10 19 separator 0.9972812 ¶ 1313 1315 W4328052409.pdf 10 20 title 0.99373055 3.6 Developing job-specific competence models 1315 1360 W4328052409.pdf 10 21 separator 0.9955851 ¶ 1360 1362 W4328052409.pdf 10 22 text 0.99915034 "After content analysis, job-sp ecific competence facets have been formulated on the basis of the interview text passages that have been mapped to the different competence cate- gories. The resulting job-speci fic competence facets were summarized to job-specific co mpetence models. The job- specific competence models se rve to further differentiate and finalize the prospective and process-related competence models. Table 7shows an example of how job-specific competence facets for the emp loyees of quality control in SME 3 have been formulated." 1362 1924 W4328052409.pdf 10 23 separator 0.9971297 ¶ 1924 1926 W4328052409.pdf 10 24 title 0.9930956 "3.7 Developing prospective and process-related competence models" 1926 1993 W4328052409.pdf 10 25 separator 0.9949132 ¶ 1993 1995 W4328052409.pdf 10 26 text 0.9995432 "In order to develop the final prospective and process-re- lated competence models, a three-step methodology was applied (Fig. 5). In a first step, the competences that have been identified and mapped by the employees to the single" 1995 2229 W4328052409.pdf 10 27 separator 0.84380734 ¶ 2229 2231 W4328052409.pdf 10 28 caption 0.99583894 Fig. 5 Process of creating a prospective and process-related competence model for the employees of quality control in SME 3 2231 2355 W4328052409.pdf 10 29 separator 0.9193 ¶ 2355 2357 W4328052409.pdf 10 30 caption 0.99632365 Abb. 5 Prozess zur Erstellung eines prospektiven und prozessbezogenen Kompetenzmodells für die Mitarbeitenden der Qualitätssicherung in 2357 2493 W4328052409.pdf 10 31 separator 0.66341436 ¶ 2493 2495 W4328052409.pdf 10 32 text 0.9977103 "KMU 3process steps during the VR-interviews were transferred to text-based templates. In this way, preliminary versions of the prospective and process-related competence models have been created. In a second step, the job-specific compe- tence facets (that have been derived after content analysis) were added to the related competence (sub-) dimensions. In a third step, the final prospective and process-related com- petence models were validated by a direct supervisor con- cerning their correctness and c ompleteness. Afterwards, the actual competence levels of the employees were also added by the ir supervisor. For this purpose, the same rating key has been used that was also applied during the VR-based expert interviews." 2495 3248 W4328052409.pdf 10 33 separator 0.99639535 ¶ 3248 3250 W4328052409.pdf 10 34 title 0.9926628 4R e s u l t s 3250 3265 W4328052409.pdf 10 35 separator 0.98091996 ¶ 3265 3267 W4328052409.pdf 10 36 title 0.99227655 4.1 Results of VR-based PCM 3267 3295 W4328052409.pdf 10 37 separator 0.99449277 ¶ 3295 3297 W4328052409.pdf 10 38 text 0.9939547 "The central results of our VR -based PCM approach are the prospective and process-related competence models. In order to create these comp etence models, job-specific competence facets were firs t formulated and summarized in respective job-specific competence models. The job- specific competence facets were i ntegrated afterwards into the preliminary versions of the prospective and process-re- lated competence models (created by the employees during K" 3297 3766 W4328052409.pdf 10 0 paratext 0.97729546 13 0 2 W4312072512.pdf 12 1 separator 0.9224289 "¶ ¶" 3 13 W4312072512.pdf 12 2 text 0.96407336 "are also shown. (b, d) Maps of SC_CPM/OB relative bi as for the 1 h (b) and 24 h (d) mean AM. In all pan els, significant differences at 5% level are indicated with a black dot and their proportion is reported as the percent age of significant cases on the total number of stations." 14 303 W4312072512.pdf 12 3 separator 0.98690283 ¶ ¶ 304 310 W4312072512.pdf 12 4 caption 0.9911012 "Figure 4. Orographic effect on 1 h and 24 h annual maxima for observation (OB), station-collocated CPM (SC_CPM), all CPM 315 grid points (GR_CPM). (a, c) Relationship of AM ra in rate with elevation at 1 h and 24 h durations, r espectively. In panel a, the linear regressions lines are shown as a solid line, are expressed as a percent of the median value and are calculated for the stations above 100 m a.s.l.; (b, d) Box plots of AM rain rat e at 1 h and 24 h durations, respectively, for the three rainfall datasets and 4 elevation groups. Note" 310 874 W4312072512.pdf 12 5 text 0.7245928 that the considered elevatio n data is the one of each dataset (OB or CPM 874 948 W4312072512.pdf 12 6 caption 0.4997857 ). 948 950 W4312072512.pdf 12 7 separator 0.9968349 ¶ 952 954 W4312072512.pdf 12 8 title 0.9930015 4.3 Hourly return levels and relation with elevatio n 320 954 1012 W4312072512.pdf 12 9 separator 0.99624836 ¶ 1013 1015 W4312072512.pdf 12 10 text 0.99868804 "We estimate the return levels of hourly precipitati on for several return periods. Results on bias asse ssment and relation with elevation are here reported for the 20 yr return le vels as reference, but similar results are found fo r return periods up to 100 yr and reported in the following Discussion section ." 1015 1335 W4312072512.pdf 12 11 separator 0.990808 ¶ 1336 1338 W4312072512.pdf 12 12 caption 0.9878834 "Figure 5 shows the comparison between estimated 20 yr return level from observations and SC_CPM (panel a), and the magnitude of the relative bias at each location (pa nel b), while the spatial distribution of the rain intensity for the 1 h 325" 1338 1586 W4312072512.pdf 12 13 separator 0.98420894 ¶ 1587 1589 W4312072512.pdf 12 14 paratext 0.9093887 https://doi.org/10.5194/egusphere-2022-1037 1589 1633 W4312072512.pdf 12 15 separator 0.6573715 ¶ 1633 1635 W4312072512.pdf 12 16 paratext 0.96079034 "Preprint. Discussion started: 17 October 2022 c Author(s) 2022. CC BY 4.0 License." 1635 1720 W4312072512.pdf 12 17 separator 0.99591887 ¶ 1720 1722 W4312072512.pdf 12 0 paratext 0.8521376 UC San Diego 0 12 W2775532084.pdf 0 1 separator 0.93717825 ¶ 12 14 W2775532084.pdf 0 2 title 0.9237183 UC San Diego Previously Published Works 14 54 W2775532084.pdf 0 3 separator 0.9946271 ¶ 54 56 W2775532084.pdf 0 4 title 0.9263942 Title 56 62 W2775532084.pdf 0 5 separator 0.95570767 ¶ 62 64 W2775532084.pdf 0 6 title 0.91783994 "Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo" 64 205 W2775532084.pdf 0 7 separator 0.96095604 ¶ 205 207 W2775532084.pdf 0 8 paratext 0.65340257 Permalink 207 217 W2775532084.pdf 0 9 separator 0.7062352 ¶ 217 219 W2775532084.pdf 0 10 paratext 0.38705748 https 219 225 W2775532084.pdf 0 11 text 0.42578492 ://e 225 229 W2775532084.pdf 0 12 paratext 0.45720032 scholarship 229 240 W2775532084.pdf 0 13 text 0.47410655 . 240 241 W2775532084.pdf 0 14 paratext 0.45317876 org 241 244 W2775532084.pdf 0 15 text 0.41086456 / 244 245 W2775532084.pdf 0 16 paratext 0.48493057 uc 245 247 W2775532084.pdf 0 17 text 0.3816145 / 247 248 W2775532084.pdf 0 18 paratext 0.53609395 item 248 252 W2775532084.pdf 0 19 text 0.45648217 /92m9k0tr 252 261 W2775532084.pdf 0 20 separator 0.9928365 ¶ 261 263 W2775532084.pdf 0 21 paratext 0.34754756 Journal 263 271 W2775532084.pdf 0 22 separator 0.86898726 ¶ 271 273 W2775532084.pdf 0 23 text 0.41335312 Journal of the American Chemical Society, 140 273 319 W2775532084.pdf 0 24 paratext 0.39807284 (1) 319 322 W2775532084.pdf 0 25 separator 0.86670864 ¶ 322 324 W2775532084.pdf 0 26 paratext 0.51670593 ISSN 324 329 W2775532084.pdf 0 27 separator 0.38348836 ¶ 329 331 W2775532084.pdf 0 28 paratext 0.38030872 0002-7863 331 341 W2775532084.pdf 0 29 separator 0.994588 ¶ 341 343 W2775532084.pdf 0 30 contact 0.92861086 Authors 343 351 W2775532084.pdf 0 31 separator 0.49485728 ¶ 351 353 W2775532084.pdf 0 32 contact 0.9871033 "Navratil, Aaron R Shchepinov, Mikhail S Dennis, Edward A" 353 414 W2775532084.pdf 0 33 separator 0.9659879 ¶ 414 416 W2775532084.pdf 0 34 title 0.37017596 Publication Date 416 433 W2775532084.pdf 0 35 separator 0.83639467 ¶ 433 435 W2775532084.pdf 0 36 paratext 0.38352865 2018-01-10 435 446 W2775532084.pdf 0 37 separator 0.9706859 ¶ 446 448 W2775532084.pdf 0 38 paratext 0.4152726 DOI 448 452 W2775532084.pdf 0 39 separator 0.54326034 ¶ 452 454 W2775532084.pdf 0 40 paratext 0.4185629 10.1021/ja 454 465 W2775532084.pdf 0 41 contact 0.4012441 cs 465 467 W2775532084.pdf 0 42 paratext 0.39085904 .7b 467 470 W2775532084.pdf 0 43 contact 0.3233578 094 470 473 W2775532084.pdf 0 44 paratext 0.40428942 93 473 475 W2775532084.pdf 0 45 separator 0.93065083 ¶ ¶ 475 481 W2775532084.pdf 0 46 paratext 0.6231396 Peer reviewed 481 495 W2775532084.pdf 0 47 separator 0.3441713 ¶ 495 497 W2775532084.pdf 0 48 paratext 0.6261332 eScholarship.org Powered by the California Digital Library 497 556 W2775532084.pdf 0 49 separator 0.9694402 ¶ 556 558 W2775532084.pdf 0 50 paratext 0.44339812 University of California 558 583 W2775532084.pdf 0 0 paratext 0.9131556 24 0 2 W2894560710.pdf 23 1 separator 0.97903436 ¶ 3 5 W2894560710.pdf 23 2 table 0.9663502 "Sdev 0.061 0.052 0.064 0.078 0.079 0.048 Accumulation [m w.eq.a–1] for 1999 –2013 Min 0.111 0.203 0.142 0.159 0.130 0.141 Mean 0.158 0.284 0.219 0.229 0.231 0.200 Max 0.284 0.378 0.333 0.295 0.353 0.311" 6 246 W2894560710.pdf 23 3 separator 0.94635963 "¶ ¶" 248 258 W2894560710.pdf 23 4 title 0.97800094 Table 2: Dating results for the six firn cores from Union Glacier based on annual layer counting (stable water isotopes and 258 383 W2894560710.pdf 23 5 separator 0.81194055 ¶ 384 386 W2894560710.pdf 23 6 title 0.7770111 glacio –chemistry) and core inter–matching taking SCH –2 as reference. 386 457 W2894560710.pdf 23 7 separator 0.9937798 ¶ 460 462 W2894560710.pdf 23 8 table 0.58946526 5 463 465 W2894560710.pdf 23 9 separator 0.8471087 ¶ 466 468 W2894560710.pdf 23 10 table 0.9794698 "Firn Core Period ¶ Total number of years (δ18O/δD summer maxima) GUPA –1 1989 –2014 26 DOTT –1 1999 –2014 16 SCH –1 1986 –2014 29 SCH –2 1977 –2015 39 BAL –1 1980 –2015 36 PASO –1 1973 –2015 43 ¶ ¶ 10 ¶ ¶ 15" 468 797 W2894560710.pdf 23 11 separator 0.9516856 ¶ 798 800 W2894560710.pdf 23 12 paratext 0.95321417 The Cryosphere Discuss., https://doi.org/10.5194/tc-2018-161 801 862 W2894560710.pdf 23 13 separator 0.94426614 ¶ 862 864 W2894560710.pdf 23 14 paratext 0.7950095 "Manuscript under review for journal The Cryosphere Discussion started: 4 October 2018" 864 952 W2894560710.pdf 23 15 separator 0.58468115 952 953 W2894560710.pdf 23 16 paratext 0.9209424 ¶ c Author(s) 2018. CC BY 4.0 License. 953 991 W2894560710.pdf 23 17 separator 0.99622893 ¶ 991 993 W2894560710.pdf 23 0 paratext 0.96861047 "El cartel ruso y soviético de 1914 a 1939 ________________________________________ _____________________________________________ Arte y Ciudad - Revista de Investigación No 21 – Abril de 2022 145" 0 208 W4285510111.pdf 12 1 separator 0.8657896 ¶ 210 212 W4285510111.pdf 12 2 text 0.9983731 "- El mal es representado de diversas maneras como un monstru o, una serpiente o un dragón, basándose en la iconografía cristiana. - Las armas: ballonetas, fusiles, cuchillos y espadas, como seguridad y garantía de victoria. Sujetas por soldados o solas haciendo una fun- ción metonímica de ejércitos entero s. También aniq uilando al enemigo y ensangrentadas o derramando sangre. Se utiliza la geometrización para hacerlas más punzantes y afiladas. - La sangre es la muerte, el dolor y el sufrimiento. - La paloma es símbolo de la paz y esperanza." 213 787 W4285510111.pdf 12 3 separator 0.9971005 ¶ 789 791 W4285510111.pdf 12 4 title 0.994094 3. Cartel ruso y soviético en el pe riodo Leninista. 791 844 W4285510111.pdf 12 5 separator 0.99602413 ¶ 846 848 W4285510111.pdf 12 6 text 0.9994968 "En el periodo comprendido entre la Revolución de Octubre y el 13 de abril de 1924 (muerte de Lenin) acontecen los hechos más importantes para la so- ciedad ruso -soviética. Hay una guerra civil, cambios estructurales económico - sociales, nace la URSS. En este periodo, el cartel ruso aporta al mund o estilos y estudios psicosociales desconocidos hasta el momento. Cumplió las funcio- nes de: potenciación de la producción, promoción de los productos estatales para desbancar a la empresa privada y agi tación política, entre otros." 848 1397 W4285510111.pdf 12 7 separator 0.9972054 ¶ 1399 1401 W4285510111.pdf 12 8 title 0.9788249 "3.1. La idea de arte y propaganda de Lenin y Lunacharski. El plan de propa- ganda monumental ." 1401 1499 W4285510111.pdf 12 9 separator 0.9958893 ¶ 1500 1502 W4285510111.pdf 12 10 text 0.9992663 "Anatoli Vasilievich Lunacharski nació en Poltava en 1885, estudió filosofía y ciencias naturales en la Universidad de Zúrich, donde e mpezó su actividad propagandística con Plejanov y Axelrod. En 1897 llegó a Rusia como revolu- cionario profesional. A partir de 1906 vivió en el exilio (Francia e Italia, fun- damentalmente) trabajando en colaboración con Lenin. Tras la revolución, fue nombrad o Primer Comisario de Instrucción Pública, cargo que ocupó hasta 1929. Durante esos años escribió numerosos artículos sobre la configuración del arte y la cultura soviética. “En 1918 me llamó Vladimir Illich y me comu- nicó que era preciso desarrollar el art e como medio de propaganda” (Luna- charski, 1969, p. 9)." 1502 2236 W4285510111.pdf 12 11 separator 0.9840404 ¶ 2238 2240 W4285510111.pdf 12 12 text 0.999532 "Los teóricos de l socialismo coincidían en que el arte es distinto según las so- ciedades y los pueblos, por lo que el arte socialista debía ser distinto al burgués y aceptado por todos. Lenin había prese ntado la necesidad de crear arte en las calles, las casas y las plazas. El estado invierte en arte. El nuevo mecenas del" 2240 2574 W4285510111.pdf 12 0 title 0.97495526 Table 3. Insurance Claims for Participants (N = 70) Covered by MassHealth (Medicaid) Related to Asthma, Reducing Racial/Ethnic Asthma Disparities in Youth 0 154 W3003462785.pdf 6 1 separator 0.9745617 ¶ 154 156 W3003462785.pdf 6 2 title 0.9161758 (READY) Study, Massachusetts, 2009–2014 156 196 W3003462785.pdf 6 3 separator 0.9818519 ¶ 196 198 W3003462785.pdf 6 4 table 0.98833954 "VariableControl Perioda Post Periodb P Valuec Mean (Standard Deviation) Mean (Standard Deviation) Participants who completed all 5 visits (n = 70) Average cost per person, $ Hospitalization 1,059.22 (3,199.62) 506.20 (1,948.86) .11 Emergency department visits 534.73 (809.61) 223.41 (473.77) .001 Office visits 473.77 (618.94) 406.17 (537.90) .32 Health care events, no. Hospitalization 0.21 (0.66) 0.10 (0.39) .11 Emergency department visits 0.93 (1.15) 0.50 (0.86) .004 Office visits 3.19 (3.28) 2.96 (3.09) .69 Participants who completed all 5 visits and had 2 or more emergency department visits during control period (n = 22) Average cost per person, $ Hospitalization 2,543.76 (4,372.83) 1,243.14 (4,378.39) .23 Emergency department 1,512.87 (828.25) 454.39 (1,206.34) .009 Office 730.22 (868.92) 739.91 (773.25) .52 Health care events, no. Hospitalization 0.64 (1.09) 0.32 (0.78) .13 Emergency department visit 2.59 (1.01) 0.95 (2.21) <.001 Office visit 4.50 (4.61) 4.86 (4.14) .65" 198 1225 W3003462785.pdf 6 5 separator 0.4927862 1225 1226 W3003462785.pdf 6 6 table 0.564451 ¶ 1226 1228 W3003462785.pdf 6 7 text 0.8627392 "a Control period was defined as 1 year prior to visit 1. b Post period was defined as 1 year after visit 5. c P < .05 indicates significance." 1228 1373 W3003462785.pdf 6 8 title 0.77879053 PREVENTING CHRONIC DISEASE VOLUME 17, E11 1373 1414 W3003462785.pdf 6 9 separator 0.9480959 ¶ 1414 1416 W3003462785.pdf 6 10 title 0.97850716 PUBLIC HEALTH RESEARCH, PRACTICE, AND POLICY FEBRUARY 2020 1416 1477 W3003462785.pdf 6 11 separator 0.98216516 ¶ 1477 1479 W3003462785.pdf 6 12 text 0.9447913 "The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors’ affiliated institutions." 1479 1753 W3003462785.pdf 6 13 separator 0.9689151 ¶ 1753 1755 W3003462785.pdf 6 14 paratext 0.7105555 www.cdc.gov/pcd/issues/2020/19_0288.htm • Centers for Disease Control and Prevention 7 1755 1848 W3003462785.pdf 6 0 paratext 0.9901914 World Electric Vehicle Journal 2019 ,10, 54 6 of 12 0 51 W2972819804.pdf 5 1 separator 0.99431336 ¶ 51 53 W2972819804.pdf 5 2 text 0.9948459 "if the reverse current is sufficiently large, the electric charge is discharged completely, and D–S voltage becomes zero. Consequently, the soft switching can be achieved in all switches in the active bridge." 53 263 W2972819804.pdf 5 3 separator 0.8906778 ¶ 263 265 W2972819804.pdf 5 4 text 0.98091215 "From the above, the requirement where soft-switching can be achieved at all switches in both active bridges can be expressed as (" 265 399 W2972819804.pdf 5 5 separator 0.9939297 ¶ 399 401 W2972819804.pdf 5 0 text 0.9534257 "fibrinogen, alpha2-macroglobulin, alpha1-acid glycoprotein, IgM, apolipoprotein AI, apolipoprotein AII, complement C3, and transthyretin." 0 139 W2345695819.pdf 3 1 separator 0.9965948 ¶ 139 141 W2345695819.pdf 3 2 title 0.9896874 Mass spectrometry 141 159 W2345695819.pdf 3 3 separator 0.9927066 ¶ 159 161 W2345695819.pdf 3 4 text 0.99927765 "For non-depleted serum samples, MALDI-TOF MS was used to identify proteins of interest from the 2D gels as previously described [10]. To increase the ability to detect smaller quantities of protein in the depleted samples, triple quadrupole/linear ion trap MS was performed using the QTRAP 5500 System (Sciex, Canada) according to stand- ard protocols. The data files were submitted to Mascot for the protein library search." 161 594 W2345695819.pdf 3 5 separator 0.99728435 ¶ 594 596 W2345695819.pdf 3 6 title 0.9908531 Statistical analysis 596 617 W2345695819.pdf 3 7 separator 0.9933851 ¶ 617 619 W2345695819.pdf 3 8 text 0.9994364 "To determine if there were significant differences between hemodynamic parameters be- tween patients with good vs. poor neurological outcome, ttests were used. Results were considered significant if p< 0.05. Due to the feasibility nature of this project, no correction was performed for multiple comparisons, as all results are considered exploratory." 619 977 W2345695819.pdf 3 9 separator 0.99709725 ¶ 977 979 W2345695819.pdf 3 10 title 0.980186 Results 979 987 W2345695819.pdf 3 11 separator 0.98461115 ¶ 987 989 W2345695819.pdf 3 12 title 0.9806501 Patients 989 998 W2345695819.pdf 3 13 separator 0.98831916 ¶ 998 1000 W2345695819.pdf 3 14 text 0.9996112 "From August 2010 to June 2014, a convenience sample of 11 patients were recruited into the study (Table 1). Of the 11 patients recruited, all but 2 were male. The median age was 61 years (range 27 –76). Five of the patients had no known cardiac history. For patient 5, the presenting rhythm was initially interpreted as ventricular fibrillation, and the patient was recruited into the study. On further review of the cardiac arrest, the ini- tial rhythm was not ventricular fibrillation, but a non-perfusing bradyarrhythmia that subsequently degenerated into ventricular fibrillation. The serum was collected, but" 1000 1626 W2345695819.pdf 3 15 separator 0.99291754 ¶ 1626 1628 W2345695819.pdf 3 16 title 0.9788269 Table 1 Patient demographics and clinical characteristics 1628 1686 W2345695819.pdf 3 17 separator 0.9510877 ¶ 1686 1688 W2345695819.pdf 3 18 table 0.99600273 "Patient # Age/gender Comorbidities Rhythm CPC Good neurological outcome 1 61 M Obesity/OA VF 1 2 76 F Obesity, HTN, DM, AS, AF PEA* 1 3 62 M COPD, CKD, CAD, DM, CHF VT 1 7 46 M Healthy VF 1 9 37 F Endometriosis, nephrolithiasis, epilepsy VT 1 10 57 M Healthy VF 1 Poor neurological outcome 4 68 M HTN, DM, smoker VF 4 5 70 M Healthy VF 5 6 47 M Healthy VF 5 8 67 M HTN, AF VF 5 11 27 M Healthy VF/VT 5" 1688 2116 W2345695819.pdf 3 19 separator 0.99512506 ¶ 2116 2118 W2345695819.pdf 3 20 text 0.809108 "The demographic information, initial rhythm, and 3-month neurological outcome are shown for the 11 patients recruited into the study" 2118 2253 W2345695819.pdf 3 21 separator 0.89734614 ¶ 2253 2255 W2345695819.pdf 3 22 text 0.79112667 "CPC cerebral performance category, VFventricular fibrillation, OAosteoarthritis, HTN hypertension, DMdiabetes mellitus, ASaortic stenosis, AFatrial fibrillation, COPD chronic obstructive pulmonary disease, CKD chronic kidney disease, CAD coronary artery disease, CHF congestive heart failure, PEA pulseless electrical activity, VTventricular tachycardia." 2255 2614 W2345695819.pdf 3 23 separator 0.4535421 2614 2615 W2345695819.pdf 3 24 text 0.46115333 ¶ 2615 2616 W2345695819.pdf 3 25 table 0.61150694 * Patient was initially classified as 2616 2655 W2345695819.pdf 3 26 text 0.5656435 having 2655 2661 W2345695819.pdf 3 27 table 0.59546566 VF, but reclassified later as 2661 2692 W2345695819.pdf 3 28 text 0.4918741 having 2692 2698 W2345695819.pdf 3 29 table 0.64229983 a non-perfusing bradycardia (see text 2698 2737 W2345695819.pdf 3 30 separator 0.35200313 ¶ 2737 2738 W2345695819.pdf 3 31 table 0.60111463 for details) 2738 2751 W2345695819.pdf 3 32 paratext 0.54049355 Boy 2751 2754 W2345695819.pdf 3 33 bibliography 0.55636585 d et al. 2754 2762 W2345695819.pdf 3 34 paratext 0.78068566 Intensive Care Medicine Experimental (2016) 4:9 Page 4 of 11 2762 2824 W2345695819.pdf 3 0 title 0.97768086 SUPPLEMENTARY INFORMATION 0 25 W4361265879.pdf 0 1 separator 0.99014366 ¶ 26 28 W4361265879.pdf 0 2 title 0.9756997 MATERIALS AND METHODS 28 50 W4361265879.pdf 0 3 separator 0.9843085 ¶ ¶ 51 57 W4361265879.pdf 0 4 text 0.9994281 "Bioinformatic analysis . Microarray data analysis was performed using GeneSpring v7.1 (Agilent Technologies UK Limited, Stockport, UK). For both 5-FU and oxaliplatin, two independent experiments we re created. Firstly, to analyse drug- inducible gene expression in HCT116 pare ntal cells, all genes on each array were normalised to the median signal intensity of that array. Secondly, each gene on the 6, 12 and 24h sample arrays was normalised to the median signa l intensity of the respective gene on the 0h (control) array. The GeneSpring Cross Gene Error Model was then applied to the experiment, with the average base/proportional values calculated from the replicated conditions of the experiment. Ge nes were filtered using three parameters. Firstly, all genes that displayed an Affymetrix present or marginal flag call in all samples were retained. The gene list was subsequently filtered using the average base/proportional values calculated from the cross gene error model, with genes displaying cont rol values greater than the average base/proportional value being re tained (this was required in all samples for any gene)." 57 1234 W4361265879.pdf 0 5 separator 0.891028 ¶ 1236 1238 W4361265879.pdf 0 6 text 0.9996429 "Finally, the list was filtered us ing a 2-fold cut-off for each gene relative to the 0h control, with genes meeting this criteri on in at least 1 of the 3 timepoints being retained. The genes passing these 3 filters were consider ed to be drug-inducible." 1238 1500 W4361265879.pdf 0 7 separator 0.98480713 ¶ 1501 1503 W4361265879.pdf 0 8 text 0.99936527 "The second experiment created aimed to compare basal gene expression in the HCT116 parental cell lin e relative to both the 5-FU- a nd oxaliplatin-resistant daughter lines. As described above, all genes on each array were initially normalised to the median signal intensity of that array. Each gene was then normalised to the median signal intensity of the respective gene on all arrays. The data was filtered as described" 1503 1935 W4361265879.pdf 0 0 paratext 0.9883815 Grünheid and Hazem 10.3389/fpubh.2023.1204662 0 45 W4381135125.pdf 6 1 separator 0.99319285 ¶ 45 47 W4381135125.pdf 6 2 text 0.99238086 "Frontiers in Public Health 07 frontiersin.orgsurvey participants were guaranteed anonymity, we relied on patient- reported outcomes and were unable to evaluate the accuracy of the reported pathologies. However, the survey contained three validated tools to gauge depression severity, level of perceived stress, and mental health status that were specifically designed for this purpose, allowing a comprehensive assessment of various aspects of mental wellbeing." 47 523 W4381135125.pdf 6 3 separator 0.78172535 ¶ 524 526 W4381135125.pdf 6 4 text 0.9993831 "Third, any survey study is limited by its response rate. A good survey response rate is generally considered to range between 5 and 30% ( 41)." 526 672 W4381135125.pdf 6 5 separator 0.7602121 ¶ 673 675 W4381135125.pdf 6 6 text 0.9994611 "Our response rate was 32%. Finally, the study is lacking comparison data obtained before pandemic onset. For this reason, we cannot confirm that the present findings were substantially impacted by COVID-19. We refrained from asking respondents to compare their current status to their pre-pandemic status as this would have introduced a response shift. Response shift refers to measurement of patient-reported outcomes that reflect better outcomes over time not because the patient is doing better but because the patient has now adapted, psychologically, to match their new life circumstances in order to better cope with them ( 42). Patient-reported outcomes such as those in the present survey are particularly prone to this change over time." 675 1452 W4381135125.pdf 6 7 separator 0.9965193 ¶ 1452 1454 W4381135125.pdf 6 8 title 0.9828121 5. Conclusion 1454 1468 W4381135125.pdf 6 9 separator 0.9964409 ¶ 1468 1470 W4381135125.pdf 6 10 text 0.99579936 "The results suggest that the mental wellbeing of frontline health workers is poor. Medical and dental workers tend to suffer from moderate to moderately severe depression, have a much higher perceived stress level than average, and have a lower level of mental health than the general population. Many are dissatisfied with healthcare and consider leaving the industry with stress and burnout being the main reasons. " 1470 1904 W4381135125.pdf 6 11 separator 0.49336088 ¶ 1904 1905 W4381135125.pdf 6 12 text 0.9988859 "Notably, all groups seem equally affected with no apparent differences between medical and dental frontline healthcare workers." 1905 2036 W4381135125.pdf 6 13 separator 0.91877675 ¶ 2036 2038 W4381135125.pdf 6 14 text 0.9992919 "Healthcare executives and leaders must understand the gravity of the situation and take action. To improve their employees’ mental wellbeing, healthcare employers should understand their baseline, ensure co-design with staff of interventions, and track progress over time so that interventions can be changed or adjusted in case they are not working. Organizations should also pay particular attention to female workers as they constitute the largest percentage of individuals with severe depression, which may be at a higher suicide risk." 2038 2599 W4381135125.pdf 6 15 separator 0.9862103 ¶ 2599 2601 W4381135125.pdf 6 16 text 0.99906003 "Primary, secondary, and tertiary prevention of loss of mental wellbeing in healthcare workers must become a priority. Leaders should focus on mental wellbeing before people start to struggle, not after. The results of this study may help design the tools to do so." 2601 2875 W4381135125.pdf 6 17 separator 0.99716866 ¶ 2875 2877 W4381135125.pdf 6 18 title 0.98838353 Data availability statement 2877 2905 W4381135125.pdf 6 19 separator 0.9932384 ¶ 2905 2907 W4381135125.pdf 6 20 text 0.99302804 "The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation." 2907 3032 W4381135125.pdf 6 21 title 0.9220933 Ethics statement 3032 3048 W4381135125.pdf 6 22 separator 0.97993386 ¶ 3048 3050 W4381135125.pdf 6 23 text 0.9894754 "This study involving human participants was reviewed and approved by the Institutional Review Boards at Essentia Health Duluth and the University of Minnesota (Study number 00016700). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements." 3050 3404 W4381135125.pdf 6 24 separator 0.9966558 ¶ 3404 3406 W4381135125.pdf 6 25 title 0.9865634 Author contributions 3406 3427 W4381135125.pdf 6 26 separator 0.99360085 ¶ 3427 3429 W4381135125.pdf 6 27 text 0.9967146 "TG contributed to data collection, curation, and analysis. TG and AH contributed to conceptualization, study design, data interpretation, manuscript drafting, reviewing and editing, and are responsible for the overall content. All authors contributed to the article and approved the submitted version." 3429 3743 W4381135125.pdf 6 28 separator 0.9967391 ¶ 3743 3745 W4381135125.pdf 6 29 title 0.9816043 Acknowledgments 3745 3761 W4381135125.pdf 6 30 separator 0.9938221 ¶ 3761 3763 W4381135125.pdf 6 31 text 0.9972937 "The authors are grateful to Essentia Health and the University of Minnesota School of Dentistry for supporting this study and to Mike John and Naveed Haider for sharing their expertise. The authors are indebted to Priscilla Flynn and her team for sharing their Minnesota State Fair PROMIS Global-10 data. Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1-TR002494. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health." 3763 4422 W4381135125.pdf 6 32 separator 0.996597 ¶ 4422 4424 W4381135125.pdf 6 33 title 0.98777926 Conflict of interest 4424 4445 W4381135125.pdf 6 34 separator 0.9918727 ¶ 4445 4447 W4381135125.pdf 6 35 text 0.9974549 "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest." 4447 4626 W4381135125.pdf 6 36 separator 0.9960418 ¶ 4626 4628 W4381135125.pdf 6 37 title 0.9819466 Publisher’s note 4628 4645 W4381135125.pdf 6 38 separator 0.98921824 ¶ 4645 4647 W4381135125.pdf 6 39 text 0.99318 "All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher." 4647 5009 W4381135125.pdf 6 40 separator 0.99607205 ¶ 5009 5011 W4381135125.pdf 6 41 title 0.9239539 References 5011 5022 W4381135125.pdf 6 42 separator 0.99230015 ¶ 5022 5024 W4381135125.pdf 6 43 bibliography 0.9978647 "1. LeGoff DB, Lazarovic J, Kofeldt M, Ghayal H, Peters A. Addressing mental health factors to improve outcomes in work-related COVID-19: a retrospective study of frontline workers. J Occup Environ Med . (2022) 64:e443–51. doi: 10.1097/JOM.0000000000002575" 5025 5287 W4381135125.pdf 6 44 separator 0.94935596 ¶ 5287 5289 W4381135125.pdf 6 45 bibliography 0.9978654 "2. Magnavita N, Soave PM, Antonelli M. A one-year prospective study of work-related mental health in the intensivists of a COVID-19 hub hospital. Int J Environ Res Public Health . (2021) 18:9888. doi: 10.3390/ijerph18189888 3. Mavrogenis AF, Scarlat MM. Stress, anxiety, and burnout of orthopaedic surgeons in COVID-19 pandemic. Int Orthop . (2022) 46:931–5. doi: 10.1007/s00264-022-05393-2" 5290 5690 W4381135125.pdf 6 46 separator 0.9654201 ¶ 5690 5692 W4381135125.pdf 6 47 bibliography 0.9977709 "4. Dragioti E, Tsartsalis D, Mentis M, Mantzoukas S, Gouva M. Impact of the COVID-19 pandemic on the mental health of hospital staff: an umbrella review of 44 meta-analyses. Int J Nurs Stud . (2022) 131:104272. doi: 10.1016/j.ijnurstu.2022." 5693 5940 W4381135125.pdf 6 48 separator 0.963256 ¶ 5942 5944 W4381135125.pdf 6 49 paratext 0.5005926 104 5944 5948 W4381135125.pdf 6 50 bibliography 0.552219 272 5948 5951 W4381135125.pdf 6 0 paratext 0.9837583 Available at www .veterinaryworld.org/V ol.7/Jan-2014/1.pdf 0 59 W2025464660.pdf 4 1 separator 0.53464967 59 60 W2025464660.pdf 4 2 paratext 0.92407674 ¶ Veterinary World, EISSN: 2231-0916 5sar 60 106 W2025464660.pdf 4 3 title 0.5221496 coma (HSA) cells and HSA tumor initiating cells at for providing 106 171 W2025464660.pdf 4 4 text 0.8840949 "the funding that allowed the conduction clinically achievable concentrations of EGFuP A, and of our experiments, and Dr. Brenda Spangler for that EGFuP A targets chemotherapy-resistant tumor helpful discussions." 171 389 W2025464660.pdf 4 5 separator 0.98816514 ¶ 390 392 W2025464660.pdf 4 6 title 0.74329036 cells and the associated tumor microvasculature [20-22]. Competing interestsNovel VEGFR-targeting compounds designed 392 509 W2025464660.pdf 4 7 text 0.95836574 "to The authors declare that they have no competing interests. deliver chemotherapeutics as well as other anticancer agents to VEGFR-expressing cancer cells may exhibit" 509 683 W2025464660.pdf 4 8 title 0.8961848 References 683 694 W2025464660.pdf 4 9 separator 0.9843359 ¶ 694 696 W2025464660.pdf 4 10 text 0.37795478 similar anticancer activity. Preclinical studies 696 745 W2025464660.pdf 4 11 bibliography 0.99712956 1. Sitohi, B., Nagy , J.A. and Dvorak, H.F. (2012) Anti-VEGF / confirming successful targeting and investigating the VEGFR therapy for cancer: reassessing the target. Cancer potential toxicity of novel compounds delivering Res., 72(8):15, 1909-1914. 745 995 W2025464660.pdf 4 12 separator 0.9607276 ¶ 995 997 W2025464660.pdf 4 13 bibliography 0.6513392 therapeutic 997 1009 W2025464660.pdf 4 14 text 0.45379293 s 1009 1010 W2025464660.pdf 4 15 bibliography 0.9683118 "to VEGFR-expressing cells are essential 2. Restucci, B., Paparella, S., Maiolino, P. and De Vico, G. (2002) Expression of vascular endothelial growth factor in prior to clinical translation of the proposed strategy . canine mammary tumors. Vet. Pathol. , 39:488-493.Based on our RT-qPCR data, we selected TLM-1 3. Wergin, M.C. and Kaser -Hotz. (2004) Plasma vascular and Grace-HSA cells as representative lines with endothelial growth factor (VEGF) measured in 70 dogs with enrichment of VEGFR1 expression to test VEGF spontaneously occurring tumors. In Vivo, 18:15-20." 1010 1587 W2025464660.pdf 4 16 separator 0.97476363 ¶ 1587 1589 W2025464660.pdf 4 17 bibliography 0.99738693 4. Tamburini, B.A,, Trapp, S., Phang, T.L., Schappa, J.T., binding. Our results confirmed a successful VEGF- 1589 1698 W2025464660.pdf 4 18 separator 0.5556146 ¶ 1698 1700 W2025464660.pdf 4 19 bibliography 0.9964028 Hunter , L.E. and Modiano, J.F. (2009) Gene expression binding that did not appear to be affected by endogenous profiles of sporadic canine hemangiosarcoma are uniquely VEGF . The greater fluorescence noted in Grace-HSA associated with breed. PLoS One, 4(5):e5549. 1700 1967 W2025464660.pdf 4 20 separator 0.96643937 ¶ 1968 1970 W2025464660.pdf 4 21 bibliography 0.7236359 compare 1970 1978 W2025464660.pdf 4 22 text 0.54985374 d to TLM-1 might be due to line 1978 2009 W2025464660.pdf 4 23 bibliography 0.41601697 age 2009 2012 W2025464660.pdf 4 24 text 0.49455237 -specific 2012 2021 W2025464660.pdf 4 25 bibliography 0.9976184 5. Yonemaru, K., Sakai, H., Yanai, T. and Masegi, T. (2006) 2021 2081 W2025464660.pdf 4 26 separator 0.8768406 ¶ 2082 2084 W2025464660.pdf 4 27 bibliography 0.860237 Expression 2084 2095 W2025464660.pdf 4 28 text 0.5817109 of vascular 2095 2107 W2025464660.pdf 4 29 bibliography 0.6002746 2107 2108 W2025464660.pdf 4 30 text 0.8826082 "endothelial growth factor , basic post-translational stabilization leading to increased fibroblast growth factor , and their receptors (FLT-1, FLK-1, receptor density . Not surprisingly , competition with and FLG-1) in canine vascular tumors. Vet" 2108 2357 W2025464660.pdf 4 31 bibliography 0.5509157 . Path 2357 2363 W2025464660.pdf 4 32 text 0.91284025 ol., 43: 971-unlabeled VEGF was more efficient in TLM1 cells that 980. 2363 2434 W2025464660.pdf 4 33 separator 0.81981874 ¶ 2434 2436 W2025464660.pdf 4 34 text 0.4464233 2436 2437 W2025464660.pdf 4 35 bibliography 0.44113114 appear 2437 2443 W2025464660.pdf 4 36 text 0.5691211 ed to have decreased surface receptors 2443 2481 W2025464660.pdf 4 37 bibliography 0.98084664 "density 6. Koch, S. and Claesson-W elsh, L. (2012) Signal transduction compared to Grace-HSA. Considering systemic concen- by vascular endothelial growth factor receptors. Cold Sprinng Harb Perspect Med. , 2:a006502. trations of VEGF in tumor bearing dogs are in the 7. Kerber , M., Reiss, Y., Wickersheim, A., Jugold, M., picomolar range [23,24], receptors in tumor cells Kiessling, F., Heil, M., Tchaikovski, V., Walternber ger, J., should be readily available for targeting under most Shibuya, M., Plate, K.H. and Machein, M.R. (2008). Flt-1" 2481 3032 W2025464660.pdf 4 38 separator 0.9003819 ¶ 3033 3035 W2025464660.pdf 4 39 bibliography 0.59953386 conditions, as 3035 3050 W2025464660.pdf 4 40 text 0.51648515 plasma levels of 3050 3067 W2025464660.pdf 4 41 bibliography 0.49518955 VE 3067 3070 W2025464660.pdf 4 42 text 0.47798365 GF have 3070 3077 W2025464660.pdf 4 43 bibliography 0.5867562 been shown signaling in macrophages promotes glioma growth in vivo. 3077 3145 W2025464660.pdf 4 44 separator 0.66407204 ¶ 3146 3148 W2025464660.pdf 4 45 bibliography 0.9796358 Cancer Res., 68:7342-7351. to be <100 pg/ml for 95-100% of tumor -bearing dogs 8. Murakami, M., Iwai, S., Hiratsuka, S., Yamauchi, M., [23,24].Nakamura, K., Iwakura, Y. and Shibuya, M. (2006) 3148 3340 W2025464660.pdf 4 46 separator 0.96878946 ¶ 3341 3343 W2025464660.pdf 4 47 title 0.87437075 Signaling of vascular endothelial growth factor receptor -1 Conclusions 3343 3415 W2025464660.pdf 4 48 separator 0.91395116 ¶ 3415 3417 W2025464660.pdf 4 49 text 0.944603 "tyrosine kinase promotes rheumatoid arthritis through In summary , canine tumor cells can show activation of monocytess/macrophages. Blood, 108:(1849- 1856). preferential expression of VEGFR1, but these cells" 3417 3632 W2025464660.pdf 4 50 bibliography 0.99007344 "9. Hurwitz, H., Fehrenbacher , L., Novotny , W., Cartwright, T., remain capable of binding native VEGF-A, thus Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., providing feasibility of targeting VEGFR-expressing Holmgren, E., Ferrara, N., Fyfe, G., Rogers, B., Ross, R. and tumor cells with cytotoxic molecules conjugated to Kabbinavar, F. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer . VEGF-A. Optimization of anti-cancer strategies N. Eng. J. Med. , 350:2335-2342.targeting VEGFR1 receptors in dogs as part of the 10. Miller , K., Wang, M., Gralow , J., Dickler , M., Cobleigh, M., process of clinical translation could provide insights on Perez, E.A., Shenkier , T., Cella, D. and Davidson, N.E. their potential efficacy and toxicity [25]. Further (2007) Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer . N. Engl. J. Med., 357:2666- studies are needed to develop strategies based on the 2676.selective delivery of therapeutic compounds against 11. Jain, R.K., Duda, D.G., Clark, J.W. and Loeffler, J.S. (2006) VEGFR-expressing tumors through VEGF-VEGFRs Lessons from phase III clinical trials on anti-VEGF therapy binding. for cancer . Nat. Clin. Pract. Oncol., 3:24-40." 3632 4926 W2025464660.pdf 4 51 separator 0.9852693 ¶ 4926 4928 W2025464660.pdf 4 52 bibliography 0.9717939 "12. Oh, S., Stish, B.J., Sachdev , D., Chen, H., Dudek, A.Z. and Authors' contributionsVallera, D.A. (2009) A novel reduced immunogenicity bispecific ligand targeted toxin simultaneously recognizing AB, CS, and JFM conceptualized the study . AB and human epidermal growth factor and interleukin-4 receptors JFM obtained funding. AB and MD performed and in a mouse model of metastatic breast carcinoma. Clin. analyzed the experiments, and wrote the initial draft of Cancer Res., 15(19): 6137-6147." 4928 5432 W2025464660.pdf 4 53 separator 0.988962 ¶ 5432 5434 W2025464660.pdf 4 54 bibliography 0.9976005 13. Spangler , C.W., Starkey , J.R., Rebane, A., Drobizhev , M., the manuscript. AB, MD, CS, JFM reviewed and edited 5434 5551 W2025464660.pdf 4 55 separator 0.74024594 ¶ 5552 5554 W2025464660.pdf 4 56 bibliography 0.9968035 Meng, F. and Gong, A. (2008) Synthesis, characterization all subsequent drafts of the manuscript. All authors and two-photon PDT efficacy studies of triads incorporating read and approved the final manuscript.tumor targeting and imaging components. Proc. Soc. Photo. 5554 5821 W2025464660.pdf 4 57 separator 0.55642384 ¶ 5822 5824 W2025464660.pdf 4 58 bibliography 0.98156357 "Opt. Instrum., Optical Methods for Tumor Treatment and AcknowledgementsDetection: Mechanisms and Techniques in Photodynamic Therapy XVII, 68450S; doi:10.1 117/12.763472. We thank the American College of Veterinary" 5824 6042 W2025464660.pdf 4 59 separator 0.98307896 ¶ 6043 6045 W2025464660.pdf 4 60 bibliography 0.9973495 "14. Hamada, Y., Gonda, K., Takeda, M., Sato, A., Watanabe, M., Internal Medicine (ACVIM) Foundation and the Yambe, T., Satomi, S. and Ohuchi, N. (2011) In vivo imaging Canine Health Foundation and the Animal Cancer Care of the molecular distribution of the VEGF receptor during and Research Program of the University of Minnesota angiogenesis in a mouse model of ischemia. Blood 118(13)." 6045 6437 W2025464660.pdf 4 0 paratext 0.9440867 "ЛИТОСФЕР А том 23 No 5 2023Шумилов Shumilov 818" 0 54 W4388454782.pdf 9 1 separator 0.9903186 ¶ 54 56 W4388454782.pdf 9 2 text 0.99840945 "щавшие их воды в случае затрудненного кислород - ного обмена теряли кислород на различные окис - лительные процессы и становились бескислород - ными. В результате этого в породах создавались благоприятные условия для развития анаэробных микроорганизмов, которые порождали, в свою оче - редь, восстановительную (глеевую) среду." 56 394 W4388454782.pdf 9 3 separator 0.97873515 ¶ 394 396 W4388454782.pdf 9 4 text 0.9929772 "Вокруг разлагающихся органических остатков в результате деятельности таких анаэробов, как молочнокислые, маслянокислые и ацетонобути - ловые бактерии (Непомилуев, Козырев, 1970), от - нимавших необходимый им кислород у минераль - ных соединений и продуцировавших большое ко - личество свободной углекислоты, образовывался ореол кислой среды, благоприятной для миграции железа. Помимо выделения масляной (бутановой) и углекислоты при бактериальном разложении ор - ганики выделяется водород – сильнейший восста - новитель:" 396 935 W4388454782.pdf 9 5 separator 0.8095491 ¶ 935 937 W4388454782.pdf 9 6 math 0.8489335 "C 6H12O6 → CH 3CH 2CH 2COOH + 2CO 2 + 2H 2 + X кал." 937 991 W4388454782.pdf 9 7 separator 0.98762345 ¶ 991 993 W4388454782.pdf 9 8 text 0.9986385 "Считается, что подвижная двухвалентная фор - ма железа выносится за пределы зоны оглеения диффузным путем в виде органометаллических комплексов, а при наличии в породах углекисло - ты – в бикарбонатной форме Fe(HCO 3)2 (Перель - ман, 1972)." 993 1245 W4388454782.pdf 9 9 separator 0.93643826 ¶ 1245 1247 W4388454782.pdf 9 10 text 0.9979987 "Однако при рассмотрении исследованных нами объектов возникает ряд вопросов, не освещенных предшественниками." 1247 1359 W4388454782.pdf 9 11 separator 0.77401626 ¶ 1359 1361 W4388454782.pdf 9 12 text 0.9994109 "В первую очередь обращает на себя внимание совпадение форм ореола оглеения и продуцирую - щей его органики, т. е. одинаковой мощности про - работки вмещающей породы во всех направлени - ях. Это указывает на то, что конечная форма зон оглеения была достигнута в отложениях, испытав - ших полное уплотнение под воздействием литоста - тического давления. В противном случае наблю - далось бы значительное искажение форм зон огле- ения по вертикали (уплощение) в результате усад - ки пород, особенно пелитолитов, изменяющих объем в разы (Фролов, 1993). При этом вся седи - ментационная вода должна быть отжата." 1361 1987 W4388454782.pdf 9 13 separator 0.99153656 ¶ 1987 1989 W4388454782.pdf 9 14 text 0.9977729 "Здесь уместно коротко рассмотреть историю геологического становления девонской толщи на территории Среднего Тимана. Как уже упомина - лось, максимальное развитие красноцветные от - ложения на Цилемской площади получили на за - вершающем этапе устьчиркинского времени кон - ца среднего девона. После этого наступил продол - жительный этап перерыва в осадконакоплении. В этот период произошла тектоническая активиза - ция района, в результате которой некоторые блоки были в значительной мере дислоцированы. Затем длительное время территория экспонировалась на дневной поверхности, в результате чего произошла ее пенепленизация (Шумилов, Тельнова, 2017). Лишь затем наступили следующие трансгрессив -но-регрессивные циклы, осадки которых погреб - ли рассматриваемые породы. Таким образом, огле-ение пород происходило на протяжении длитель - ного времени, измеряемого тысячами или даже сотнями тысяч лет." 1989 2909 W4388454782.pdf 9 15 separator 0.9786205 ¶ 2909 2911 W4388454782.pdf 9 16 text 0.99951106 "Возникает вопрос: могло ли разложение орга - нического материала происходить с участием ана - эробных бактерий на протяжении указанного вре - мени? Или биохимические процессы начально - го этапа сменились физико-химическими? Дело еще в том, что углефицированная органика райо - на также обладает специфическими особенностя - ми: сочетает в себе свойства двух угольных анта - гонистов – фюзена и гагата (Шумилов, 2015). В ре - зультате каких процессов получились такие объек - ты, непонятно до сих пор. Эти обстоятельства об - условливают проблему выделенных захороненной органикой реагентов, приведших к оглеению вме - щающих пород." 2911 3572 W4388454782.pdf 9 17 separator 0.9908335 ¶ 3572 3574 W4388454782.pdf 9 18 text 0.99947864 "Вернемся к форме и характеру границ зон огле - ения. Если бы реагенты были в виде жидкости, то она либо стекала вниз под воздействием гра - витации, либо поднималась вверх по капиллярам. В том и другом случаях было бы искажение форм зон оглеения в вертикальном направлении. Сле - дует заметить, что красноцветные глинистые по - роды обладают превосходными консервирующи - ми свойствами. Так, псевдоморфозы джарлеита по растительной органике, находясь даже в русле реки на глубине первых сантиметров, не несут никаких признаков окисления. Это при том, что джарлеит, относясь к высшим сульфидам меди, неустойчив в зоне гипергенеза. Следовательно, рассматрива - емые глинистые породы непроницаемы для жид - костей. Если реагенты были бы газообразными, то они поднимались бы вверх, что также приводи - ло бы к увеличению верхних частей зон оглеения. Кроме того, ранее описано, что в случае развития глеевых процессов в слоистых породах не отмеча - ется более интенсивного восстановления по более проницаемым песчанистым слоям и слойкам." 3574 4628 W4388454782.pdf 9 19 separator 0.98860836 ¶ 4628 4630 W4388454782.pdf 9 20 text 0.99956566 "Учитывая перечисленные факты, мы считаем, что основным способом движения реагентов, при - ведших к оглеению красноцветов, была диффузия молекул, атомов, ионов. Не исключено, что глав - ным агентом оглеения (восстановления) был во - дород в ионной Н + (своеобразная протонная эмис - сия) или молекулярной форме H 2. Именно в силу малых размеров для их диффузии не существует преград. С такой точки зрения можно объяснить, почему, казалось бы, в более проницаемых песча - никах зоны оглеения развиты на расстояние, вдвое меньшее от органики, чем в глинистых отложени - ях. Скорее всего, дело в кристаллической плот - ности минералов, слагающих породы, – обломки кварца и вулканического стекла менее проницае - мы для диффузии, чем минералы глин." 4630 5398 W4388454782.pdf 9 0 separator 0.63803476 1 2 W2138646798.pdf 0 1 paratext 0.8413286 ¶ 1501 1 8 W2138646798.pdf 0 2 separator 0.97546333 ¶ 8 10 W2138646798.pdf 0 3 title 0.98832417 INTRODUCTION 10 23 W2138646798.pdf 0 4 separator 0.98396796 ¶ ¶ 24 30 W2138646798.pdf 0 5 text 0.999633 "Iron (Fe) is an essential element for livestocks as well as human beings. NRC (1994) suggested that the Fe requirement should be 50-120 ppm for poultry, and Fe toxicity appears at a very high level over 2,000 ppm. It is well known that white meats, such as breast meat of broilers, are low in Fe content than red meats, such as beef. Extra supplementation of Fe in addition to meeting nutritional requirement of chicken would enable enrichment of Fe in white meat. Iron enriched broiler meat may meet the demand of niche market customers looking for such functional products." 30 622 W2138646798.pdf 0 6 separator 0.9565251 ¶ 623 625 W2138646798.pdf 0 7 text 0.9966651 "Since a few years ago, researches on organic minerals have been actively undertaken because chelate minerals can be more effectively absorbed into the intestines than inorganic oxide and sulfate (W edekind et al., 1992; Aoyagi and Baker, 1993). In the same way, Fe may have big difference in bioavailability according to the form of supply. As it was found that chelate minerals which are new organic compounds of the metal enhanced the productivity of livestock because they have a higher bioavailability than inorganic minerals, intensive researches on this issue have been conducted (Kratzer an d V ohra, 1986). Organic minerals, in particular, amino acids and low molecule peptide (Miller et al., 1972; McNaughton et al., 1974; Zoubek et al., 1975; Spears, 1992 ) in the state of chelation with metal ions are more effectively absorbed into the body (Fouad, 1976; Ashmead, 1993). It is because chelation of metal ions with organic substances such as amino acids or low molecule peptide makes metal ions electrically neutral and chemically stable, thereby allowing easy passage through the small intestinal wall. Actually, 95% of them are absorbed (Kratzer and V ohra, 1986). Paik (2001" 625 1845 W2138646798.pdf 0 8 paratext 0.96411365 ") reported Asian-Aust. J. Anim. Sci. Vol. 21, No. 10 : 1501 - 1505 October 2008 ¶ www.ajas.info" 1845 1961 W2138646798.pdf 0 9 separator 0.78668606 ¶ ¶ 1963 1969 W2138646798.pdf 0 10 title 0.97294414 "The Effect of Level and Period of Fe-methionine Chelate Supplementation on the Iron Content of Boiler Meat" 1969 2081 W2138646798.pdf 0 11 separator 0.9914296 ¶ ¶ 2083 2089 W2138646798.pdf 0 12 contact 0.97918516 "S. H. Seo1, H. K. Lee1, W. S. Lee2, K. S. Shin and I. K. Paik * Department of Animal Science and Technology, Chung-Ang University, Ansung-si, Kyunggi-do, 456-756, Korea" 2089 2261 W2138646798.pdf 0 13 separator 0.97104895 ¶ ¶ 2263 2269 W2138646798.pdf 0 14 text 0.9913411 "ABSTRACT : A broiler experiment was conducted to compare the effect s of duration and level of iron-methionine chelate (Fe-Met) supplementation on the iron, copper (Cu) and zinc (Zn) content of broiler meat. Two hundred and fifty hatched Ross broiler chick ens were randomly assigned to 5 dietary treatments. Each treatment had 5 replicates of 10 birds (5 males and 5 females) each. Birds were housed in raised floor batteries and fed traditional broiler diets ad libitum for 5 weeks. Dietary treatments were as follows: Control and two levels of Fe-Met (100 or 200 ppm in Fe) supplemented for either the whole period (0 -5 wk) or grower period (4-5 wk). Produc tion performance was not significantly affected by treatments. Iron content in the muscles (b reast, leg and wing) and organs (liver and spleen) were significantly (p<0.05) increa sed as the level and duration of Fe-Met s upplementation increased. The highest concen tration of iron was shown in Fe-Met 200 fed for the whole period. Live r contained the highest amount of iron followed by spleen, leg mu scle, wing muscle and breast muscle. Supplementation of Fe-Met 200 for the grower period resulted in higher iron concentration in liv er and spleen than supplementation of Fe-Met 100 fo r the whole period. However, the same tr eatment resulted in lower iron concentratio n in muscles (breast, leg and wing) than the treatment of Fe-Met 100 for the whole period. In order to achieve the highest iron enri chment in the muscles, Fe-Met should be supplemented at 200 ppm in Fe fo r the whole period (5 wks). Fe-Met supplementation increased copp er concentration in all muscles and organs exce pt wing muscle. Zinc concentr ation decreased in breast and wing muscle but tended t o increase in leg muscle, liver and spleen by Fe-Met 200 supplementa tion. Color of muscle was not si gnificantly affected by Fe-Me t treatments. However, redness of leg and br east muscle, and yellowness of leg and breas t muscle tended to increase by supplement ation of Fe-Met for the whole period. It was concluded that iron conten t of broiler meat can be effectively enriched by supplementati on of 200 ppm of Fe as Fe-Met for 5 wks. (Key Words : Fe-methionine Chelate, Iron Enriched Meat, Broiler, Copper, Zinc)" 2269 4584 W2138646798.pdf 0 15 separator 0.9742147 ¶ ¶ 4585 4591 W2138646798.pdf 0 16 contact 0.9964204 "* Corresponding Author: InKee Paik. Tel: +82-31-670-3028, E-mail: ikpaik@cau.ac.kr" 4591 4676 W2138646798.pdf 0 17 separator 0.91864145 ¶ 4677 4679 W2138646798.pdf 0 18 contact 0.97361505 "1 Cargill Agri Purina Inc. Korea. 2 Daejoo Co. Ltd. Korea." 4679 4741 W2138646798.pdf 0 19 separator 0.9274932 ¶ 4742 4744 W2138646798.pdf 0 20 paratext 0.98110795 Received February 1, 2008; Accepted May 2, 2008 4744 4792 W2138646798.pdf 0 0 paratext 0.97750527 "4 Vol:.(1234567890) Scientific Reports | (2023) 13:5064 | https://doi.org/10.1038/s41598-023-32383-0" 0 112 W4361222741.pdf 3 1 separator 0.7640281 ¶ 112 114 W4361222741.pdf 3 2 paratext 0.8336751 www.nature.com/scientificreports/ 114 148 W4361222741.pdf 3 3 title 0.98470867 Morphologic analysis. Morphological characteristics for plant growth analysis of transgenic cotton plants 148 253 W4361222741.pdf 3 4 separator 0.9432002 ¶ 254 256 W4361222741.pdf 3 5 text 0.9995462 "were carried out by measuring plant height, Root to shoot ratio, root-to-total plant weight ratio (RWR), stem- to-total plant weight ratio (SWR), leaf-to-total plant weight ratio (LWR) and fresh and dry biomass as compared to non-transgenic control cotton plants at 0, 5 and 10 days of drought stress. The height of plants was measured from the soil surface to the apex using a measuring tape. The shoot length was measured from apex to the base of the hypocotyl. The root length was measured from tip of the root to the hypocotyl base at day 0, 5 and 10 day of drought stress. Three plants from each transgenic and non-transgenic line were selected. The root to shoot length ratio was calculated for each plant by taking values and means of measurement. For data collection, the parameters like root, stem and leaf to total plant weight ratio for transgenic and non-transgenic control plants under drought stress were taken. Plants were unsoiled and the fresh weight in gram (g) per plant was taken. Then plants were wrapped in brown papers and kept at 80 °C for 48 h. After that, dry weight was measured in g per plant. Percent reduction in biomass was measured at 0, 5 and 10 days after drought stress." 256 1491 W4361222741.pdf 3 6 separator 0.99358565 ¶ 1491 1493 W4361222741.pdf 3 7 text 0.65428036 Physiological and 1493 1511 W4361222741.pdf 3 8 title 0.52740353 bio 1511 1515 W4361222741.pdf 3 9 text 0.9884396 "chemical analysis. Physiological characteristics like Leaf relative water content (LRWC), chlorophyll content, photosynthesis, transpiration rate, and stomatal conductance of transgenic and non-transgenic cotton plants were calculated at 0, 5 and 10 day of drought stress by taking means of three values of each parameter. The leaf relative water content was calculated by taking a leaf sample 0.1 g from each treat- ment according to the method described by22. The chlorophyll a and chlorophyll b (photosynthetic pigments) were calculated according to23. Infra-Red Gas Analyzer (IRGA)was used to measure the net photosynthesis rate, transpiration rate, and stomatal conductance. Biochemical characteristics like Proline and the total soluble sugars were estimated by following the method described by24,25, respectively. After completion of all the param- eters’ analysis, seeds were collected and stored for the study of the next generation." 1515 2483 W4361222741.pdf 3 10 separator 0.9640057 ¶ 2483 2485 W4361222741.pdf 3 11 text 0.99923503 "Statistical analysis. Graph Pad Prism7 was used for statistical analysis by subjecting the data for 2-way analysis of variance (ANOV A) to find out the significant difference in the mean." 2485 2676 W4361222741.pdf 3 12 separator 0.9953351 ¶ 2676 2678 W4361222741.pdf 3 13 title 0.875365 Results 2678 2686 W4361222741.pdf 3 14 separator 0.99494815 ¶ 2686 2688 W4361222741.pdf 3 15 text 0.9996851 "Structural and functional analysis of GaZnF gene. Clustering analysis of the ZF-HD family showed that 22 TFs were divided into 3 main subfamilies A, B and C. Family B is further divided into two subgroups (B1&B2). GaZnF belongs to subgroup B2 (Fig. 1a). The protein sequences of ZF-HD from 10 different species were obtained by NCBI alignment. It was found that GaZnF had a genetic relationship with Gossypium raimon - dii and Gossypium arboreum in the evolutionary process (Fig. 1b). Amino acid motifs retrieved from MEME suite software (Fig. 1c). The chemical formula of GaZnF is determined as C761H1219N233O240S17, the relative molecular weight is 18,017.49 Da and the theoretical isoelectric point was 8.66. The total counts of negatively charged residual bases (Asp + Glu) are 15, and the total counts of positively charged residual bases (Arg + Lys) are found to be 20. The fat coefficient of the peptide chain is 3605, and the instability coefficient is 2980. The instability index (II) is calculated to be 38.26. The above-mentioned characteristics classify the GaZnF protein as stable. Trans-membrane domain is found in the intramembrane protein encoded by GaZnF (Fig. 1Sa), and there is Meth signal peptide at the N-terminal of GaZnF. It is therefore speculated that the protein encoded by GaZnF is a non-secretory protein (Fig. 1Sb). Plant TFDB predicted the GaZnF protein binding motif (Fig. 1Sc). The sec- ondary structure of the GaZnF protein contained 41.18% α helix (Hh), 4.62% extended chain (Ee), 1.68% β angle (Tt) and 52.52% irregular crimped (Cc) (Fig. 1d,e). Several motifs related to plant stress resistance are found in the 518 bp region upstream of GaZnF, including MYB transcription factors (CNGTTR motif) that regulate many stress responses, especially against drought stress in plants. The WRKY plant-specific transcription factor (motif TGAC) playing important roles in many different response pathways of diverse abiotic stresses (drought, saline, temperature, alkali and ultraviolet radiation) is a stress-related cis component (W-box)." 2688 4813 W4361222741.pdf 3 16 separator 0.99046016 ¶ 4813 4815 W4361222741.pdf 3 17 text 0.99834156 "Cloning of GaZnF in TA & pCAMBIA-1301 vector. cDNA synthesized by using total RNA from drought-stressed leaves was observed in Fig. 2a. A fragment of 531 bp released through restriction digestion by EcoRI confirmed the cloning of GaZnF in TA vector (Fig. 2b). The PCR amplification (Fig. 2c) with gene- specific primers of GaZnF and restriction digestion with Nco I and BglII (Fig. 2d) confirmed the cloning of gene in pCAMBIA-1301 vector. The graphical representation of full-length GaZnF gene is shown in (Fig. 2e)." 4815 5349 W4361222741.pdf 3 18 separator 0.9965559 ¶ 5349 5351 W4361222741.pdf 3 19 title 0.9477038 Transformation of pGaZnF in Agrobacterium and transient expression. 5351 5419 W4361222741.pdf 3 20 text 0.58121675 Colon 5419 5425 W4361222741.pdf 3 21 title 0.5428098 y 5425 5427 W4361222741.pdf 3 22 text 0.60587716 PCR with Ga 5427 5438 W4361222741.pdf 3 23 title 0.5197277 Z 5438 5439 W4361222741.pdf 3 24 text 0.6085967 nF 5439 5441 W4361222741.pdf 3 25 separator 0.80613816 ¶ 5442 5444 W4361222741.pdf 3 26 text 0.99746794 "gene specific primers confirms the transformation of pCAMBIA35S-GaZnF in Agrobacterium competent cells (Fig. 3a). The development of blue spots in the agro-infiltrated leaf confirmed the transient expression of GUS. The control leaf had no blue spots (Fig. 3b,c)." 5444 5715 W4361222741.pdf 3 27 separator 0.99596906 ¶ 5715 5717 W4361222741.pdf 3 28 title 0.8360287 Transformation of pGaZnF in local variety of cotton. Local cotton variety CIM-482 ( 5717 5801 W4361222741.pdf 3 29 text 0.64923847 G. 5801 5803 W4361222741.pdf 3 30 title 0.620205 hirsutum 5803 5812 W4361222741.pdf 3 31 text 0.54368037 ) 5812 5814 W4361222741.pdf 3 32 separator 0.73292255 ¶ 5815 5817 W4361222741.pdf 3 33 text 0.9993067 "is selected for GaZnF gene transformation, and seeds of cotton variety (CEMB-482) are collected from CEMB Research Station Multan (30° 5′ 0′′ N, 71° 40′ 0′′ E) Punjab, Pakistan. During this study total of 7000 embryos were isolated (Fig. 4c), and co-cultivated with Agrobacterium containing pGaZnF by co-cultivation (Fig. 4a,b).," 5817 6156 W4361222741.pdf 3 34 separator 0.9810854 ¶ 6157 6159 W4361222741.pdf 3 35 text 0.99957246 "A total of 500 putative transgenic plants, are shifted to shoot-inducing medium. Out of these, 320 plants survived after 8 weeks, having well-developed shoots and roots in selection media. Non-transgenic plants are also shifted to shoot and root-inducing medium (Fig. 4d). Total of 180 putative transgenic plants with well-developed roots and shoots are shifted to soil pots. Non-transgenic plants are also shifted to soil pots (Fig. 4e,f). The overall effi- ciency of transformation is 2.57% (Table 1)." 6159 6676 W4361222741.pdf 3 0 paratext 0.98318005 Page 4/18 0 9 W4396216348.pdf 3 1 text 0.93116504 safe, and its e 9 24 W4396216348.pdf 3 0 text 0.99957305 "pair AflII-f and MspI-r (Table 5). The primers ClaI-f and AflII-r were then used to amplify the whole recombinant plasmid sequence of pUC-PCV1, including the pUC-18vector and the PCV1 genome without its ORF2 se- quence. The expected PCR products were ligated together to create recombinant plasmid pUC-PCV12, which con-tained the PCV2 capsid gene cloned into the backbone of the PCV1 genome. The PCV12 genome was excised and recircularized. The duplicated fragment was then ampli-fied from the circularized PCV12 genome with primers EcoRV-f12 and EcoRI-r12 and subcloned into pUC- PCV12 to generate the chimeric PCV12 DNA clone pIS-PCV12 (Figure 1A)." 0 666 W2137079923.pdf 6 1 separator 0.9969496 ¶ 666 668 W2137079923.pdf 6 2 title 0.9933103 In vitro characterization of PCV12 668 703 W2137079923.pdf 6 3 separator 0.9928043 ¶ 703 705 W2137079923.pdf 6 4 text 0.99970585 "To determine the infectivity and in vitro growth charac- teristics of the progeny PCV12 viruses, PK-15 cells grown to 80% confluency in 6-well plates were trans-fected with 20 μg of PCV1, PCV2 and PCV12 DNA clone as described previously [15]. The cells in each well were collected 5 days post-transfection and were thenfrozen and thawed three times. Subsequently, the cell lysates were used to inoculate fresh PK-15 cells growing in T-25 flasks, which were incubated for five days andthen passaged serially 26 times. The in vitro viability and growth activity of the progeny viruses were evaluated by IFA as described previously [15]." 705 1356 W2137079923.pdf 6 5 separator 0.99689424 ¶ 1356 1358 W2137079923.pdf 6 6 title 0.99336755 In vivo experimental design 1358 1386 W2137079923.pdf 6 7 separator 0.9941982 ¶ 1386 1388 W2137079923.pdf 6 8 text 0.99972355 "One hundred and sixteen 7-week-old BALB/C micewere used for the in vivo experiment, twenty of which were randomly selected before inoculation to undergo nucleic acid and serological screening for PCV to con-firm that the animals used in the study were initially PCV-free. The remaining mice were divided into six groups of sixteen animals each and housed in pens inseparate rooms, where they were acclimatized for 7 days before inoculation. As a negative control, the mice in group 1 were inoculated intranasally and intraperitone-ally with culture fluid (MEM). Mice in groups 2 and 3 were inoculated intranasally and intraperitoneally with 0.2 ml (50 μg) of the PCV1 and PCV2 DNA clones." 1388 2093 W2137079923.pdf 6 9 separator 0.881178 ¶ 2093 2095 W2137079923.pdf 6 10 text 0.9996168 "Group 4 animals were inoculated with 0.2 ml (50 μg) of the PCV12 DNA clone. Animals in groups 5 and 6 were inoculated with 0.2 ml (50 μg) of the chimeric PCV1- NLS2 and PCV2-NLS1 DNA clones [15]. All mice were monitored daily for health status and possible clinical signs. Four mice in each group were euthanized bybleeding at 7, 14, 28 and 42 days post-inoculation (dpi)." 2095 2478 W2137079923.pdf 6 11 separator 0.96910024 ¶ 2478 2480 W2137079923.pdf 6 12 text 0.99872833 "Blood and tissue samples were collected from euthanized mice and stored at −80°C for further studies. The animal experiments in this study were approved by the Animal Welfare Committee of Zhejiang University (protocol No. 20100134)." 2480 2721 W2137079923.pdf 6 13 title 0.9912135 Serological study 2721 2738 W2137079923.pdf 6 14 separator 0.9938985 ¶ 2738 2740 W2137079923.pdf 6 15 text 0.99968475 "Antibodies to PCV1 or PCV2 in the serum of eacheuthanized mouse were detected by modified indirectELISA based on the recombinant ORF2 capsid protein of PCV1 or PCV2 as described previously [24,25]." 2740 2940 W2137079923.pdf 6 16 separator 0.9966898 ¶ 2940 2942 W2137079923.pdf 6 17 title 0.9911806 Pathological analysis 2942 2964 W2137079923.pdf 6 18 separator 0.99268556 ¶ 2964 2966 W2137079923.pdf 6 19 text 0.99972236 "For microscopic study, sections of spleen, lung and mes- enteric lymph nodes were fixed in 4% phosphate-buffered paraformaldehyde. The sections were then dehydrated, embedded in paraffin, stained with hematoxylin and eosin(HE) and finally evaluated under a microscope. Lesion scores for lymphoid tissues were estimated in blinded samples based on the level of lymphoid depletion andhistiocytic infiltration, with scores ranging from 0 (normal or no lymphoid depletion) to 3 (severe lymphoid depletion and histiocytic infiltration)." 2966 3512 W2137079923.pdf 6 20 separator 0.99655163 ¶ 3512 3514 W2137079923.pdf 6 21 title 0.994023 Viral detection by taqman PCR 3514 3544 W2137079923.pdf 6 22 separator 0.993376 ¶ 3544 3546 W2137079923.pdf 6 23 text 0.9997288 "Blood samples from euthanized mice were collected dur-ing necropsy and were stored at −80°C before DNA ex- traction. Viral DNA was extracted from serum using the QIAamp DNA Blood kit (QIAGEN, USA) according tothe manufacturer ’s instructions. The amount of PCV DNA obtained from serum was determined using PCV1 or PCV2 ORF2-based primer pairs and probes [15]." 3546 3914 W2137079923.pdf 6 24 separator 0.9964909 ¶ 3914 3916 W2137079923.pdf 6 25 title 0.9936657 Immunohistochemistry (IHC) analysis 3916 3952 W2137079923.pdf 6 26 separator 0.9922842 ¶ 3952 3954 W2137079923.pdf 6 27 text 0.9997223 "Specific antigens of PCV1, PCV2 and the three chimeric viruses were detected by IHC in paraffin-embedded sections of lymph node collected at 28 and 42 dpi usingpolyclonal antiserum to PCV1 or PCV2 according to the procedures described previously [23]. The polyclonal antiserum to PCV1 or PCV2, which was raised in rabbitsby immunization with PCV1 and PCV2 viral proteins, have been confirmed as type-specific by immunofluores- cence assay and western blot [25]. The amounts of specificantigen distributed in the tissues were scored blindly on a scale of 0 (for no signal) to 3 (for a strong positive signal)." 3954 4577 W2137079923.pdf 6 28 separator 0.9967158 ¶ 4577 4579 W2137079923.pdf 6 29 title 0.9922134 Statistical analysis 4579 4600 W2137079923.pdf 6 30 separator 0.994341 ¶ 4600 4602 W2137079923.pdf 6 31 text 0.9995775 "Results were presented as averages ± the standard devia- tions. Associations between rates of pathological lessions (normal, mild, moderate and severe) and amounts of viral antigens in the lymph nodes (negative, mild, moderate andstrong) were assessed using the χ 2test. Differences were considered significant when P < 0.05." 4602 4938 W2137079923.pdf 6 32 separator 0.9961798 ¶ 4938 4940 W2137079923.pdf 6 33 title 0.98567784 Competing interests 4940 4960 W2137079923.pdf 6 34 separator 0.9888638 ¶ 4960 4962 W2137079923.pdf 6 35 text 0.9885682 The authors declare that they have no competing interests. 4962 5021 W2137079923.pdf 6 36 separator 0.99439794 ¶ 5021 5023 W2137079923.pdf 6 37 title 0.98221993 Authors ’contributions 5023 5046 W2137079923.pdf 6 38 separator 0.98701763 ¶ 5046 5048 W2137079923.pdf 6 39 text 0.9373485 "JS designed the whole project, carried out the DNA clone construction, performed data analysis and drafted the manuscript. XZ contributed to the construction of PCV12DNA clone, serological study and histopathologicalanalysis. WC performed in vitro characterization of PCV12 DNA clone. KLShuai et al" 5048 5351 W2137079923.pdf 6 40 paratext 0.97244835 . Virology Journal 2013, 10:16 Page 7 of 8 5351 5393 W2137079923.pdf 6 41 separator 0.56844866 5393 5394 W2137079923.pdf 6 42 paratext 0.95796907 ¶ http://www.virologyj.com/content/10/1/16 5394 5436 W2137079923.pdf 6 0 paratext 0.95874965 "Вісник Київського національного університету імені Тараса Шевченка Серія фізико-математичні науки 2021, 4 Bulletin of Taras Shevchenko National University of Kyiv Series Physics & Mathematics ¶ УДК 539.375" 0 228 W4285529981.pdf 0 1 separator 0.87038106 ¶ ¶ 231 237 W4285529981.pdf 0 2 contact 0.9487252 "Зражевський Г.М.1, к.ф.-м.н., доцент, Зражевська В.Ф.2, к.ф.-м.н., доцент." 237 315 W4285529981.pdf 0 3 separator 0.97448736 ¶ ¶ 316 322 W4285529981.pdf 0 4 title 0.9808002 "Комбінування детермінованого та стохастичного методів до розв’язання задачі дефектоскопії пружного стрижня" 322 435 W4285529981.pdf 0 5 separator 0.9887545 ¶ ¶ 436 442 W4285529981.pdf 0 6 contact 0.98978674 "1 Київський національний університет імені Тараса Шевченка, 83000, м. Київ, пр-т. Глушкова 4д, е-mail: zgrig@univ.kiev.ua 2 Національний технічний університет України «Київський політехнічний інститут імені Ігоря Сікорського», 03056, м. Київ, пр-т. Перемоги, 37, е-mail: vera.zrazhevska@gmail.com G.M. Zrazhevsky1, PhD, V.F. Zrazhevska2, PhD." 442 815 W4285529981.pdf 0 7 separator 0.95453525 ¶ ¶ 816 822 W4285529981.pdf 0 8 title 0.8895094 "Deterministic and stochastic methods combining while solving the problem of defectoscopy of an elastic rod" 822 935 W4285529981.pdf 0 9 separator 0.9893598 ¶ ¶ 936 942 W4285529981.pdf 0 10 contact 0.99451506 "1 Taras Shevchenko National University of Kyiv, 83000, Kyiv, Glushkova av., 4d, е-mail: zgrig@univ.kiev.ua" 942 1057 W4285529981.pdf 0 11 separator 0.5379426 ¶ 1058 1060 W4285529981.pdf 0 12 contact 0.994471 "2 National Technical University of Ukraine ""Igor Sikorsky Kiev Polytechnic Institute"", 03056, Kyiv, Peremogi av., 37, е-mail: vera.zrazhevska@gmail.com" 1060 1222 W4285529981.pdf 0 13 separator 0.9250482 "¶ ¶" 1223 1233 W4285529981.pdf 0 14 text 0.99934727 "У роботі розглянута задача про власні гармонійні коливання пружного стрижня з вільними від напружень торцями при наявності в ньому одного або сукупності дефектів. Дефекти моделюються неоднорідністю модуля Юнга. За параметри дефектів прийняті їх розташування, геометричні розміри, що вважаються малими, та зміни пружних властивостей. Предметом дослідження є аналіз зсувів власних частот коливань, що спричинені дефектністю стрижня. Метою роботи є математичне обґрунтування для побудови швидких та стійких алгоритмів визначення параметрів дефектності пружних тіл шляхом аналізу вільних коливань. У роботі використовуються та порівнюються принципово різні методи дослідження. Перші методи є класичними математичними методами механіки, що застосовуються до аналізу детермінованих систем та базуються на аналітичних дослідженнях, поєднаних з чисельною реалізацією. На противагу їм, для розв’язання оберненої задачі використаний Bootstrap-aggregated Regression Trees (BART) - метаалгоритм композиційного машинного навчання, що стандартним чином застосовується в статистичній класифікації та регресуванні." 1233 2368 W4285529981.pdf 0 15 separator 0.9792291 ¶ 2371 2373 W4285529981.pdf 0 16 bibliography 0.5582514 Ключ 2373 2378 W4285529981.pdf 0 17 text 0.45273572 ові 2378 2381 W4285529981.pdf 0 18 bibliography 0.6877973 "слова: гармонійні коливання стрижня, власні частоти, дефектоскопія, Bootstrap- aggregated Regression Trees." 2381 2491 W4285529981.pdf 0 19 separator 0.9764416 ¶ ¶ 2492 2498 W4285529981.pdf 0 20 text 0.99784017 "The paper considers the problem of natural harmonic oscillations of an elastic rod with stress-free ends in the presence of one or a set of defects. Defects are modeled by the inhomogeneity of the Young's modulus. The location of the defects, their geometric size, which is considered small, and the change in elastic properties are the parameters of the defects. The analysis of natural frequency shifts caused by the defect of the rod is the subject of the study. The aim of the work is a mathematical substantiation for the construction of fast and stable algorithms for determining the defect parameters of elastic bodies by analyzing free oscillations. The paper uses and compares fundamentally different research methods. The first methods are classical mathematical methods of mechanics, applied to the analysis of deterministic systems and based on analytical studies combined with numerical implementation. In contrast, a composite machine learning meta-algorithm used in standard statistical classification and regression - Bootstrap-aggregated Regression Trees (BART) - is used to solve the inverse problem. When comparing the constructed algorithms, the statistical method Sampling was used, which allowed to quantify the accuracy and stability of the algorithms." 2498 3807 W4285529981.pdf 0 21 separator 0.98172915 ¶ 3808 3810 W4285529981.pdf 0 22 bibliography 0.88961023 "Key words: harmonic rod oscillations, natural frequencies, flaw detection, Bootstrap-aggregated Regression Trees." 3810 3927 W4285529981.pdf 0 23 separator 0.9793742 ¶ 3928 3930 W4285529981.pdf 0 24 paratext 0.731169 "Статтю представив д.ф.-м.н., проф. , член-кор. НАН України Жук Я.О. © Г." 3930 4007 W4285529981.pdf 0 25 bibliography 0.46368587 М 4007 4008 W4285529981.pdf 0 26 paratext 0.4617516 . Зражевський, 4008 4022 W4285529981.pdf 0 27 bibliography 0.43579063 В 4022 4024 W4285529981.pdf 0 28 paratext 0.4543674 . 4024 4025 W4285529981.pdf 0 29 bibliography 0.48200873 Ф 4025 4026 W4285529981.pdf 0 30 paratext 0.68793267 ". Зражевська, 2021 ¶ 35" 4026 4053 W4285529981.pdf 0 31 separator 0.62670255 ¶ 4053 4055 W4285529981.pdf 0 32 paratext 0.9837022 https://doi.org/10.17721/1812-5409.2021/4.4 4055 4099 W4285529981.pdf 0 0 text 0.99966705 "perpendicular to the root axis (Figures 1b, 2c). Nevertheless, meticulous observations revealed three exceptions. First, cortical microtubules exhibited random orientation in cells that had just accomplished cell division (Figure 1c, pointed by arrow). Second, in cells preparing for formative divisions, either periclinal or tangentially anticlinal, cortical microtubules were transverse to the growth axis of each cell but not to the root axis (Figure 1d, arrow). Third, cortical microtubules under the external protodermal cell wall exhibited a loose longitudinal (i.e. parallel to the root axis) orientation (Figure 1e, arrows) similar to the pattern reported previously [ 39]. However, in these cells cortical microtubules under the radial anticlinal walls and the inner periclinal wall were transversely oriented, perpendicular to the root axis (Figures 1f, pointed by arrows). Apart from these deviations, microtubules were transverse in the inner cell files of the meristematic root zone, including the cortex, endodermis and stele (Figures 1b)." 0 1085 W2063471760.pdf 3 1 separator 0.97343796 ¶ 1085 1087 W2063471760.pdf 3 2 text 0.99973834 "In the transition zone, cortical microtubules under the external protodermal cell wall shifted from loosely longitudinal (Figure 3a; included in bracket) to transverse (Figure 3a , arrows). Consequently, transverse microtubule orientation was uniform in every cell of this zone (Figure 2c), as well as of the fast elongation zone (Figures 3b, c, 2c), while this pattern was altered in the cells of the growth terminating zone (Figure 3d , arrows; [ 35]). Accordingly, transverse orientation of cortical microtubules was established in the meristematic zone and persisted through the transition and fast elongation zones of A. thaliana root." 1087 1749 W2063471760.pdf 3 3 separator 0.9954481 ¶ 1749 1751 W2063471760.pdf 3 4 title 0.98009425 "Inhibition of cellulose biosynthesis resulted in reorientation of cortical microtubules in the fast elongation zone" 1751 1871 W2063471760.pdf 3 5 separator 0.99154043 ¶ 1871 1873 W2063471760.pdf 3 6 text 0.9997315 "To address the question whether defective cell wall synthesis may influence the orientation of microtubules in root tips, the pattern of cortical microtubules in than heterozygous and pom2-4 root tips was examined. The function of CesA3 is aberrant in than mutants, resulting in reduced cellulose synthesis and plant growth [ 33]. Heterozygous than/ + plants are semi-dwarf (Figure 2j), while than homozygous seedlings die soon after germination [ 33]. Homozygous CSI1 /pom-pom2 (csi1/pom2 ) seedlings also exhibit reduced growth phenotype (Figure 2j) with decreased cellulose content and defective hypocotyl and root cell elongation [12-14]." 1873 2537 W2063471760.pdf 3 7 separator 0.97942984 ¶ 2537 2539 W2063471760.pdf 3 8 text 0.99972856 "Similarly to wild-type root tips, cortical microtubule orientation was transverse in the meristematic (Figures 4a, pointed by arrows, 4d) and transition (Figures 4b, included by bracket, 4e) zones of than/+ and pom2-4 (Figures 2d, e) root tips. Cortical microtubules remained transverse in the epidermal cells of the fast elongation zone located close to the transition zone, while the orientation changed in the elongated cells proximal to the growth terminating zone in both than/+ (Figures 2e, 4b, c , arrows) and pom2-4 (Figures 2d, 4f). Measurements of the LEH and of the length of adjacent elongation zone epidermal cells confirmed that the final cell length was significantly reduced in both mutants compared to wild-type seedlings (Figures 2a, b). These results demonstrate that genetic defects in cellulose synthesis restrain cell expansion and modify theorientation of cortical microtubules only in the zone of fast elongation." 2539 3509 W2063471760.pdf 3 9 separator 0.9844167 ¶ 3509 3511 W2063471760.pdf 3 10 text 0.9996908 "Given that genetic impairment of cellulose synthesis induced the above results, we assessed the effect of chemical inhibition of cellulose synthesis on cortical microtubules. The cellulose synthesis inhibitor isoxaben [ 40] was applied on wild-type (Figure 2k) and mutant seedlings. Isoxaben treatment for 4-6 h did not exert any effect on the transverse microtubule orientation of the cells in the meristematic (Figure 2f, 5a) and transition (Figures 2f, 5d , arrowheads) zones of wild-type roots." 3511 4024 W2063471760.pdf 3 11 separator 0.98282784 ¶ 4024 4026 W2063471760.pdf 3 12 text 0.9997248 "Cortical microtubules remained transverse in the short cells located rootward in the fast elongation zone (Figure S1 , arrows), but were reoriented in the elongated epidermal cells located shootward, proximal to the growth terminating zone (Figures 2f, 5e). Isoxaben treatment for 6 h also reduced the length of fast elongation zone cells in wild-type roots, as indicated by measurements of the LEH and of the length of adjacent cells rootward (Figures 2a, b). This also indicates that a biophysical feedback from the cell wall affects the transverse orientation of cortical microtubules." 4026 4633 W2063471760.pdf 3 13 separator 0.9767958 ¶ 4633 4635 W2063471760.pdf 3 14 text 0.99967456 "The pattern of microtubule organization in than/+ and pom2-4 meristematic zone cells remained transverse when treated with isoxaben (Figures 5b, c), but it was altered in the cells of the transition and fast elongation zones (Figures 5f, g )." 4635 4885 W2063471760.pdf 3 15 separator 0.9690218 ¶ 4885 4887 W2063471760.pdf 3 16 text 0.9996265 "The extension of microtubule reorientation in the transition zone results from the combinatorial action of genetic defects and chemical inhibition of cellulose synthesis, indicating that intense perturbation of cellulose biosynthesis affected the pattern rootward. This also underlines the interplay between cellulose synthesis and microtubule orientation." 4887 5254 W2063471760.pdf 3 17 separator 0.99643135 ¶ 5254 5256 W2063471760.pdf 3 18 title 0.9690914 "Inhibition of cell expansion results in cortical microtubule reorientation in the elongation zone" 5256 5356 W2063471760.pdf 3 19 separator 0.99161875 ¶ 5356 5358 W2063471760.pdf 3 20 text 0.99974114 "Since impaired cellulose synthesis reduced cell length and concomitantly induced cortical microtubule reorientation, the effects of cell growth inhibitors on the orientation of microtubules were investigated (Figure 2k). The cellulose- binding stain Congo red inhibits cell expansion without affecting cellulose synthesis, by potentially uncoupling cellulose polymerization from its crystallization into microfibrils [ 41,42]." 5358 5797 W2063471760.pdf 3 21 separator 0.9668584 ¶ 5797 5799 W2063471760.pdf 3 22 text 0.99971694 "Similarly to isoxaben, Congo red apparently decreased cell length in the fast elongation zone (Figures 2a, b). Cortical microtubule orientation remained transverse in the meristematic and transition zones of wild-type root tips treated with Congo red for 6 h (Figures 2g, 6a, b, arrowheads)." 5799 6099 W2063471760.pdf 3 23 separator 0.81568205 ¶ 6099 6101 W2063471760.pdf 3 24 text 0.9997583 "However, in the fast elongation zone this pattern changed in the cells located shootward, close to the growth terminating zone (Figures 2g, 6c, arrows), albeit it was still transverse in the cells located rootward, close to the transition zone ( Figure 6c; included in bracket)." 6101 6388 W2063471760.pdf 3 25 separator 0.95222354 ¶ 6388 6390 W2063471760.pdf 3 26 text 0.99958235 "As expected, the meristematic cells of wild-type roots treated simultaneously with Congo red and isoxaben for 6 h had transverse cortical microtubules (Figure 6d). However, the orientation was modified in the cells of the transition and fast elongation zones (Figures 6e, f). In pom2-4 and than/+ root tips treated with Congo red cortical microtubules remained transverse in the meristematic (Figures 7a, b) and transitionCortical Microtubules in Arabidopsis thaliana Root" 6390 6877 W2063471760.pdf 3 27 separator 0.961457 ¶ 6877 6879 W2063471760.pdf 3 28 paratext 0.9829173 PLOS ONE | www.plosone.org 4 December 2013 | Volume 8 | Issue 12 | e82442 6879 6953 W2063471760.pdf 3 0 paratext 0.9819142 "e-ISSN : 2828 -0490 ¶ 86 | Dina Kartika, Riska , Yessi Mardiana ; Dns Server And Web Server ..." 0 102 W4392466785.pdf 3 1 separator 0.962093 ¶ ¶ 103 109 W4392466785.pdf 3 2 text 0.9769677 "4. Implementation . Dalam implementasi networker’s akan menerapkan semua yang telah direncanakan dan di design sebelumnya. Implementasi merupakan tahapan yang sangat menetukan dari berhasil atau gagalnya projek yang akan di bangun." 110 348 W4392466785.pdf 3 3 separator 0.9654755 ¶ 350 352 W4392466785.pdf 3 4 text 0.98408264 "5. Monitoring. Tahapan monitoring merupakan tahapan yang penting, agar jaringan komputer dan komunikasi dapat berjalan sesuai dengan ke inginan." 352 500 W4392466785.pdf 3 5 separator 0.94739974 ¶ 502 504 W4392466785.pdf 3 6 text 0.99753577 "6. Management . Pada manajement perhatian khusus adalah masalah policy, kebijakan perlu dibuat untuk membuat a tau mengatur agar system yang telah dibangun berjalan dengan baik dapat berlangsung lama dan unsur reliability terjaga." 504 741 W4392466785.pdf 3 7 separator 0.9946586 ¶ ¶ 743 750 W4392466785.pdf 3 8 title 0.99110097 HASIL DAN PEMBAHASAN 750 771 W4392466785.pdf 3 9 separator 0.9949353 ¶ ¶ 773 779 W4392466785.pdf 3 10 text 0.99579746 "Pengujian ini dilakukan dengan 5 tahap terdiri dari pengujian performansi dengan 10 user, 20 user,30 user,50 user dan 100 user sebagai berikut :" 779 927 W4392466785.pdf 3 11 separator 0.9946161 ¶ 929 931 W4392466785.pdf 3 12 title 0.91086304 1. Pengujian performansi dengan 10 user 931 971 W4392466785.pdf 3 13 separator 0.98111784 ¶ 972 974 W4392466785.pdf 3 14 text 0.9959126 "pengujian ini menggunakan perintah top pada linux. perintah ini digunakan untuk melihat proses yang sedang berjalan, pada gambar 2. terdapat proses bind yaitu proses aplikasi DNS server . Digunakan untuk mengubah ip address menjadi nama domain. Terdapat pula proses root merupakan proses login user root pada server . Proses www -data digunakan untuk menyimpan konfigurasi data web server . Selain itu terdapat pula proses login user root d an dina. Ketika 10 user mengakses web server secara bersamaan didapatkan memory yang digunakan sebesar 205.1 mb dengan persentase cpu 0.5 %." 974 1578 W4392466785.pdf 3 15 separator 0.977516 "¶ ¶" 1580 1590 W4392466785.pdf 3 16 caption 0.9688392 Gambar 2 Pengujian Performansi Dengan 10 User 1590 1636 W4392466785.pdf 3 17 separator 0.98923075 ¶ ¶ 1638 1644 W4392466785.pdf 3 18 text 0.8696421 "Pada gambar 3. pengujian network menggunakan aplikasi nl oad pada akses 10 user menghasilkan bandwith masuk sebesar 112.74 kBit/s dan bandwith keluar 1.96 MBit/s rata -rata bandwith saat mengakses menggunakan 10 user sebesar 62.11kBit/s. Total bandwith pada saat akses 10 user sebesar 1.72 Mbyte." 1644 1956 W4392466785.pdf 3 0 paratext 0.98275596 "Page 2 of 4 Opinion Paper http://www.sajid.co.za Open Access" 0 62 W3134490656.pdf 1 1 title 0.98854566 "Mechanism of action of Bacille Calmette – Guerin and purified protein derivative" 62 148 W3134490656.pdf 1 2 separator 0.9851758 ¶ 148 150 W3134490656.pdf 1 3 text 0.9997115 "When exposed to Mycobacterium tuberculosis antigen, the sensitisation initiates in the regional lymph nodes where T-lymphocytes proliferate in response to the antigenic stimulus to give rise to specifically sensitised lymphocytes, which may exist in the circulation up to many years. Antigen is presented to T-cells by being ingested by antigen presenting cells (APC), which then present it on their surface to lymphocytes in combination with various major histocompatibility molecules once they reach local lymph nodes. Purified protein derivative (PPD) is a source of mycobacterial antigens, which consist of approximately 200 protein allergens obtained from the precipitate of M. tuberculosis culture supernatant. When these antigens are injected intradermally into the skin, activated T-lymphocytes mount immune response to these antigens." 150 1035 W3134490656.pdf 1 4 separator 0.7864983 ¶ 1036 1038 W3134490656.pdf 1 5 text 0.9996635 "Molecular analyses of PPD has revealed that four heat shock proteins (GroEl, GroEs, DnaK and HspX) contribute to roughly 60% of the PPD proteomic content. These chaperone proteins share a high homology and are conserved amongst most mycobacterial species.5,6" 1038 1309 W3134490656.pdf 1 6 separator 0.649163 1309 1310 W3134490656.pdf 1 7 text 0.99832433 "¶ Purified protein derivative most likely interacts with toll- like receptor 2 expressed on APCs that initiates an inflammatory response. Subsequent restimulation of the sensitised lymphocytes with the same or a similar antigen, such as the intradermal injection of PPD, evokes a local reaction mediated by these cells. This reaction is referred to as a delayed-type hypersensitivity response that includes vasodilation, edema and the infiltration of lymphocytes, basophils, monocytes and neutrophils into the site of antigen injection. The sensitised antigen-specific T-lymphocytes proliferate and release lymphokines, which mediate the accumulation of other cells at the site. In vitro studies show that PPD promotes the upregulation of vascular endothelial growth factor (VEGF) expression in T-lymphocytes through MHC class II interaction with CD4+ T-lymphocyte interaction.7 The reactions are evident after 5–6 h following administration." 1310 2300 W3134490656.pdf 1 8 separator 0.95007384 ¶ 2300 2302 W3134490656.pdf 1 9 text 0.9989921 "Purified protein derivative is a cell-free purified protein fraction obtained from a human strain of M. tuberculosis grown on a protein-free synthetic medium and inactivated." 2302 2484 W3134490656.pdf 1 10 separator 0.9175793 ¶ 2485 2487 W3134490656.pdf 1 11 text 0.999689 "The sensitisation following BCG injection occurs primarily in the regional lymph nodes. T-lymphocytes proliferate in response to the antigenic stimulus to give rise to specifically sensitised lymphocytes. After 3–8 weeks, these lymphocytes enter the blood stream and circulate for years. Subsequent restimulation of these sensitised lymphocytes with the PPD evokes a strong cellular immune response." 2487 2905 W3134490656.pdf 1 12 separator 0.8818246 ¶ 2906 2908 W3134490656.pdf 1 13 text 0.9996427 "Purified protein derivative is a complex mixture of mycobacterial peptides, which cannot initiate an immune response to itself when injected alone in the body of a naïve animal or human not sensitised with mycobacterial antigens." 2908 3147 W3134490656.pdf 1 14 separator 0.6679581 ¶ 3148 3150 W3134490656.pdf 1 15 text 0.99974895 "However, if PPD is injected in an animal presensitised with mycobacterial antigens, it elicits a strong immune response to itself. Purified protein derivative acts as a strong carrier molecule when conjugated with a hapten and injected in an animal presensitised with mycobacterial antigens,8 for example, infection with mycobacteria or vaccination with BCG. It stimulates T-helper response to itself and a high magnitude immune response (humoral and cellular) to the hapten conjugated to it because of the linked recognition of the hapten and the carrier PPD. The same principle has been exploited earlier to enhance anti-tumour immune response9 by conjugating PPD onto the tumour cells and injecting it into BCG primed mice. However, in this model, the lymphokine secretion by PPD – specific helper T-cells will be directed onto the target PPD – bearing tumour cells and the proliferation of anti-tumour lymphocytes will be the result of the bystander effect." 3150 4158 W3134490656.pdf 1 16 separator 0.99546814 ¶ 4158 4160 W3134490656.pdf 1 17 title 0.99149376 "The hypothesis of strategy for selective in vivo immunostimulation" 4160 4230 W3134490656.pdf 1 18 separator 0.99186814 ¶ 4230 4232 W3134490656.pdf 1 19 text 0.9997328 "An alternative strategy proposed by us10 envisaged a focused secretion of lymphokines like IL2 by helper T-cells directly onto the effector lymphocytes (anti-tumour T-cells in our case) bringing in a high magnitude of selective in vivo amplification of desired T-cells minimising the chances of non-specific amplification of harmful lymphocytes like the anti-idiotypic or the suppressor lymphocytes and phagocytes." 4232 4666 W3134490656.pdf 1 20 separator 0.96671593 ¶ 4666 4668 W3134490656.pdf 1 21 text 0.9997214 "B-cells constitutively express MHC class II molecules and can process and present antigens to helper T-cells. Activated T-lymphocytes (including the cytotoxic T-cells) from some species of animals such as rats and humans express MHC class II molecules on their surface and can present antigenic peptides to the helper T-cells. Purified protein derivative is a complex mixture of mycobacterial peptides and can be presented by MHC II bearing cells without any further processing." 4668 5171 W3134490656.pdf 1 22 separator 0.9049607 ¶ 5171 5173 W3134490656.pdf 1 23 text 0.9996884 "We had proposed10 that in vitro activated autologous anti- tumour T-cells bearing MHC II on their surface, if pulsed with PPD and re-infused in a BCG – primed patient, can activate PPD – specific helper T-cells and the focused secretion of lymphokines like the IL-2 can selectively amplify the anti-tumour T-cell response by their proliferation and activation in a specific manner bypassing the suppression exerted by the anti-idiotypic and suppressor cells ( Figure 1)." 5173 5669 W3134490656.pdf 1 24 separator 0.97090065 ¶ 5669 5671 W3134490656.pdf 1 25 text 0.9803158 "Bacille Calmette – Guerin boosts the immune system to fight not only against tuberculosis but other infections also. A 2018 study suggested that the BCG vaccine reduced yellow fever vaccine viremia by 71 % in volunteers in the Netherlands. Two mice studies showed that it reduces the severity of mengovirus (encephalomyocarditis virus) infection.1 Purified protein derivative immunotherapy for the treatment of warts involves single or multiple intradermal injections of PPD antigens in the substance of viral warts at the specific interval till there is a disappearance of viral warts. Repeated injections mount booster response to PPD antigens. Activated" 5671 6358 W3134490656.pdf 1 0 paratext 0.9876895 Page 2/25 0 9 W4220701469.pdf 1 1 title 0.48523444 Abstract 9 17 W4220701469.pdf 1 2 separator 0.995268 ¶ 17 19 W4220701469.pdf 1 3 text 0.9953946 "We present a seismic source characterization model for the probabilistic seismic hazard assessment (PSHA) of the Isfahan urban area, Iran. We compiled the required datasets including the earthquake catalogue and the geological and seismotectonic structure and faults systems within the study region to delineate and characterize seismic source models. We identi" 19 385 W4220701469.pdf 1 0 paratext 0.94134676 "Xi and Yang Lipids in Health and Disease (2024) 23:40 https://doi.org/10.1186/s12944-024-02027-x RESEARCH Open Access © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data." 0 1244 W4391615626.pdf 0 1 title 0.9510849 Lipids in Health and Disease 1244 1272 W4391615626.pdf 0 2 separator 0.69597673 ¶ 1272 1274 W4391615626.pdf 0 3 title 0.9761252 "Association between cardiometabolic index and controlled attenuation parameter in U.S. adults with NAFLD: findings from NHANES (2017–2020)" 1274 1422 W4391615626.pdf 0 4 separator 0.99108994 ¶ 1422 1424 W4391615626.pdf 0 5 contact 0.9204603 Wen‐feng Xi1 and Ai‐ming Yang1* 1424 1456 W4391615626.pdf 0 6 separator 0.9949696 ¶ 1457 1459 W4391615626.pdf 0 7 title 0.96010584 Abstract 1459 1468 W4391615626.pdf 0 8 separator 0.99576324 ¶ 1469 1471 W4391615626.pdf 0 9 text 0.99896985 "Background Cardiometabolic index (CMI), a novel indicator that combines abdominal obesity and lipid levels, has been confirmed to correlate with non‐alcoholic fatty liver disease (NAFLD). However, limited research has been conducted on the relationship between CMI and controlled attenuation parameter (CAP), a parameter measured by transient elastography and reflecting the extent of fat accumulation in the liver. The objective of our study was to investigate the relationship between the two variables." 1471 1989 W4391615626.pdf 0 10 separator 0.9944538 ¶ 1989 1991 W4391615626.pdf 0 11 title 0.6245228 Methods 1991 1999 W4391615626.pdf 0 12 text 0.99493307 "This was a cross‐sectional study with a sample size of 1,759 U.S. adults with NAFLD sourced from the NHANES 2017–2020. Participants with a median CAP ≥ 248 dB/m were considered to have hepatic steatosis. CMI was calculated as [waist circumference (cm)/height(cm)]×[TG (mmol/L)/HDL ‐C (mmol/L)]. Multivariate linear regression, generalized additive model and subgroup analysis were employed to examine the association of CMI and CAP ." 1999 2445 W4391615626.pdf 0 13 separator 0.99182606 ¶ 2445 2447 W4391615626.pdf 0 14 text 0.9992415 "Results The average age of the 1,759 participants was 50.2 years, with males accounting for 50.76% and females 49.24%. The average BMI was 32.23 kg/m2. The multivariate linear regression model indicated that with every 1‐unit increase in CMI, there was an associated rise of 10.40 dB/m in CAP (95% CI, 7.14–13.67) after adjusting for covariates and a p for trend < 0.05 suggested the existence of a linear association between the two variables. Similarly, general‐ ized additive model also found it a roughly linear relationship between the two. Subgroup analysis revealed a positive correlation in the majority of subgroups." 2447 3087 W4391615626.pdf 0 15 separator 0.9930252 ¶ 3087 3089 W4391615626.pdf 0 16 title 0.73775005 Conclusions 3089 3101 W4391615626.pdf 0 17 text 0.99952716 "CMI was positively associated with CAP in U.S. adults with NAFLD. Our findings indicated that CMI may serve as an ideal indicator for monitoring the degree of hepatic steatosis among patients with NAFLD." 3101 3308 W4391615626.pdf 0 18 separator 0.9963292 ¶ 3308 3310 W4391615626.pdf 0 19 title 0.6013361 Keywords 3310 3319 W4391615626.pdf 0 20 text 0.7012156 Non‐alcoholic fatty liver disease, CMI, NHANES, Crosssectional study 3320 3389 W4391615626.pdf 0 21 separator 0.996433 ¶ 3389 3391 W4391615626.pdf 0 22 title 0.89446515 Introduction 3391 3404 W4391615626.pdf 0 23 separator 0.99166554 ¶ 3404 3406 W4391615626.pdf 0 24 text 0.99732107 "Non-alcoholic fatty liver disease (NAFLD) stands as the predominant etiological factor behind chronic liver dis - eases with a prevalence of up to approximately 25% [1]. Concurrently, with the escalating prevalence of obe - sity and metabolic syndrome, the global incidence of NAFLD exhibits an upward trajectory. NAFLD harbors the potential for deleterious progression, ranging from" 3406 3806 W4391615626.pdf 0 25 contact 0.9897804 "*Correspondence: Ai‐ming Yang yangam2020@126.com" 3806 3859 W4391615626.pdf 0 26 separator 0.815479 ¶ 3859 3861 W4391615626.pdf 0 27 contact 0.9896634 "1 Department of Gastroenterology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China" 3861 4083 W4391615626.pdf 0 0 paratext 0.6924552 Proof For Review 0 16 W2548069382.pdf 5 1 separator 0.9715921 ¶ 16 18 W2548069382.pdf 5 2 title 0.6697572 5identify 19 29 W2548069382.pdf 5 3 text 0.5036672 the δ 29 35 W2548069382.pdf 5 4 title 0.4864782 13 C 35 40 W2548069382.pdf 5 5 text 0.5766468 changes associated with ROECE and DICE, carbonate and organic 109 40 109 W2548069382.pdf 5 6 separator 0.5612553 ¶ 109 110 W2548069382.pdf 5 7 text 0.8242125 carbon isotope results are presented here. 110 110 158 W2548069382.pdf 5 8 separator 0.7978554 ¶ 111 ¶ 159 169 W2548069382.pdf 5 9 title 0.99234265 2. Geological setting and study locations 169 211 W2548069382.pdf 5 10 separator 0.9028092 112 ¶ 211 218 W2548069382.pdf 5 11 text 0.99694383 "An almost continuous belt of Cambro0Ordovician rock s crop out along the 113 Caledonian foreland within the Moine Thrust Zone of northwestern Scotland, from 114 Loch Eriboll in the north to the Isle of Skye in th e southwest (Fig. 1 ; Raine & Smith, 115 2012) . These strata record deposition on the southeaster n Laurentian margin and 116 are characterised by the predominance of marine san dstones of the Ardvreck Group 117 and limestones and dolostones of the Durness Group. The Salterella Grit Member of 118 the An t0Sròn Formation forms the uppermost part of the Ardvreck Group and 119 consists of Skolithos 0bioturbated cross0stratified, quartz arenitic sandstones (McKie, 120 1989, 1990). The transition to the Ghrudaidh Format ion of the Durness Group marks 121 the establishment of a thick succession of doloston e and limestone beds that formed 122 in a range of supratidal, peritidal and shallow marin e carbonate platform deposits 123 (Raine & Smith, 2012). Quartz sand grains persist f or a few metres in the basal 124 Ghrudaidh Formation but their disappearance at high er levels has been attributed to 125 an abrupt transgression causing the sediment hinterland to b ecome far distant 126 (Raine & Smith, 2012). 127" 218 1498 W2548069382.pdf 5 12 separator 0.815117 ¶ 128 ¶ 1499 1509 W2548069382.pdf 5 13 paratext 0.4582871 2. 1509 1512 W2548069382.pdf 5 14 title 0.39265037 a. Loch Eriboll 1512 1527 W2548069382.pdf 5 15 paratext 0.24568099 (58° 1527 1532 W2548069382.pdf 5 16 text 0.25526324 28 1532 1534 W2548069382.pdf 5 17 math 0.25473052 ' 1534 1535 W2548069382.pdf 5 18 text 0.24587104 56.64 1535 1540 W2548069382.pdf 5 19 math 0.2642691 """" 1540 1541 W2548069382.pdf 5 20 paratext 0.20873004 N 1541 1543 W2548069382.pdf 5 21 math 0.2410701 , 1543 1544 W2548069382.pdf 5 22 title 0.22098467 1544 1545 W2548069382.pdf 5 23 paratext 0.2290608 4° 1545 1547 W2548069382.pdf 5 24 text 0.22671562 40 1547 1549 W2548069382.pdf 5 25 math 0.20655623 ' 1549 1550 W2548069382.pdf 5 26 bibliography 0.17997047 0 1550 1551 W2548069382.pdf 5 27 text 0.23818693 1.01 1551 1555 W2548069382.pdf 5 28 title 0.25878203 """ W)" 1555 1559 W2548069382.pdf 5 29 separator 0.89094335 129 ¶ 1559 1566 W2548069382.pdf 5 30 text 0.99373066 "A promontory on the western shore of Loch Eriboll i s one of the few localities 130 in NW Scotland in which the An t0Sròn, Ghrudaidh an d the lower portion of the 131 Eilean Dubh formations are well exposed without a s ignificant tectonic break (Raine 132 & Smith, 2012). The outcrop spans the upper Pipe Ro ck Member of the Eriboll 133 Formation through the Fucoid and Salterella Grit me mbers, and the Ghrudaidh 134 Formation to a level above its boundary with the Ei lean Dubh Formation. 135" 1566 2077 W2548069382.pdf 5 31 separator 0.72171533 ¶ 2078 2080 W2548069382.pdf 5 32 paratext 0.48198584 136 2081 2085 W2548069382.pdf 5 33 separator 0.87204486 ¶ 2086 2088 W2548069382.pdf 5 34 paratext 0.44867605 2.b. Ardv 2088 2098 W2548069382.pdf 5 35 bibliography 0.40398684 reck 2098 2102 W2548069382.pdf 5 36 paratext 0.4223587 Castle 2102 2109 W2548069382.pdf 5 37 bibliography 0.38107935 "(58°10'12.51"" N, 4°59'55.00"" W" 2109 2140 W2548069382.pdf 5 38 paratext 0.89690024 ) 137 Page 5 of 28 Proof For Review 2140 2176 W2548069382.pdf 5 39 separator 0.97957206 ¶ 2177 2179 W2548069382.pdf 5 40 paratext 0.6359296 "1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60" 2179 2468 W2548069382.pdf 5 0 paratext 0.83970135 H. Shahverdi et al. / Clustering of parameter sensitivities: Examples from a helicopter airframe model updating exercise 85 0 123 W4250157793.pdf 10 1 separator 0.99585164 ¶ 123 125 W4250157793.pdf 10 2 caption 0.9958308 Fig. 8. Correlation of the finite element model and test data. 125 187 W4250157793.pdf 10 3 separator 0.9738027 ¶ 187 189 W4250157793.pdf 10 4 caption 0.995152 Fig. 9. MAC table after offset correction and updating. 189 245 W4250157793.pdf 10 5 separator 0.9924525 ¶ 245 247 W4250157793.pdf 10 6 text 0.9982326 "It is known that there are principally two tools, sensitivity analysis and subset selection, for the selection of parameters in model updating. In the case of very large and complicated systems these two tools on their own are insufficient to compare the many possible sensitivity columns. Clustering methods are able to carry out this taskefficiently and together with sensitivity analysis and subset selection provide a method for including the effects of" 247 707 W4250157793.pdf 10 0 paratext 0.9837399 Revista Ibero - Americana de Humanidades, Ciências e Educação - REASE 0 69 W3201737220.pdf 10 1 separator 0.6481347 "¶ ¶" 77 87 W3201737220.pdf 10 2 paratext 0.97438264 "Revista Ibero -Americana de Humanidades, Ciências e Educação. São Paulo, v.7.n.9. set. 2 021. ISSN - 2675 – 3375 200" 87 210 W3201737220.pdf 10 3 separator 0.99239445 ¶ 212 214 W3201737220.pdf 10 4 text 0.9990695 "De acordo com as dimensões fornecidas, apenas um retângulo de 5X8, com perímetro de 26 unidade s obedeceria de forma aproximada o padrão áureo de 1,618." 214 372 W3201737220.pdf 10 5 separator 0.7604252 ¶ 374 376 W3201737220.pdf 10 6 text 0.9979093 "Dentro desse contexto, qual seria a probabilidade, de uma pessoa “ao acaso” pintar 26 quadradinhos de forma aleatória, e como consequência obter um retângulo que obedece a proporção ?" 376 572 W3201737220.pdf 10 7 separator 0.8049482 ¶ 573 575 W3201737220.pdf 10 8 text 0.99722505 "Para responder essa pergunta, a fim de verificar a capacidade do acaso de gerar esse padrão precisamos determinar o número de eventos favoráveis ao experimento, e em seguida determinar o espaço amostral." 575 785 W3201737220.pdf 10 9 separator 0.76256084 ¶ 787 789 W3201737220.pdf 10 10 text 0.9983932 "Com o auxílio do software “scratch ”, verificou -se que o n úmero de retângulos áureos que podem ser construídos dentro da malha corresponde a um total de 27." 789 951 W3201737220.pdf 10 11 separator 0.8645748 ¶ 953 955 W3201737220.pdf 10 12 text 0.9751864 "Observe abaixo o exemplo de uma das 27 posições diferentes que o retângulo pode ser construído:" 955 1054 W3201737220.pdf 10 13 separator 0.9940938 ¶ 1056 1058 W3201737220.pdf 10 14 caption 0.9841547 Imagem 13 : Retângulo áureo 1111 1139 W3201737220.pdf 10 15 separator 0.76076794 ¶ ¶ 1141 1147 W3201737220.pdf 10 16 caption 0.80430937 Fonte: autor 1147 1160 W3201737220.pdf 10 17 separator 0.991642 ¶ 1162 1164 W3201737220.pdf 10 18 text 0.9832527 "Agora é necessário determinar o espaço amostral, isto é, o número de combinações diferentes que podem ser feitas dentro da malha a partir do preenchimento de 26 quadrados, para isso usaremos a fórmula de combinação simples. ¶" 1164 1401 W3201737220.pdf 10 19 separator 0.5646056 1409 1410 W3201737220.pdf 10 20 text 0.4911114 ¶ 1410 1411 W3201737220.pdf 10 21 separator 0.7956794 ¶ 1423 1425 W3201737220.pdf 10 22 text 0.990151 "Sendo C = combinações possíveis e sem repetição, n= total de elementos disponíveis para as combinações, e p = número de elementos que se deseja agrupar." 1425 1584 W3201737220.pdf 10 23 separator 0.8502451 ¶ 1586 1588 W3201737220.pdf 10 24 text 0.98898447 Onde temos: 1588 1600 W3201737220.pdf 10 25 separator 0.9947428 ¶ 1602 1604 W3201737220.pdf 10 0 paratext 0.93991655 Trevor Cohn January 2012 0 25 W4245437313.pdf 17 1 separator 0.81501377 ¶ 26 28 W4245437313.pdf 17 2 title 0.4660048 28 29 W4245437313.pdf 17 3 paratext 0.5054679 - December ¶ 29 42 W4245437313.pdf 17 4 title 0.610507 2012 (Austria)Learning. 42 66 W4245437313.pdf 17 5 separator 0.9861082 ¶ 67 69 W4245437313.pdf 17 6 contact 0.7549157 "Adam Bermingham and Alan F. Smeaton" 69 114 W4245437313.pdf 17 7 table 0.71209794 "Irish General Election, 2011.February 8th - February 25th" 114 177 W4245437313.pdf 17 8 separator 0.9233036 ¶ 178 180 W4245437313.pdf 17 9 table 0.53728235 "2011Hybrid Senti" 180 200 W4245437313.pdf 17 10 title 0.41355482 ment 200 204 W4245437313.pdf 17 11 table 0.49296406 ¶ & 205 209 W4245437313.pdf 17 12 text 0.3714685 Volume 209 216 W4245437313.pdf 17 13 table 0.53478134 .+/- 3.7% MAE 216 229 W4245437313.pdf 17 14 separator 0.9329847 ¶ 229 231 W4245437313.pdf 17 15 contact 0.46714693 Andreas 231 239 W4245437313.pdf 17 16 table 0.36791378 ¶ 240 242 W4245437313.pdf 17 17 contact 0.5992676 Jungherr 242 251 W4245437313.pdf 17 18 table 0.635887 "2009 German Federal ElectionMid June - Early October" 251 309 W4245437313.pdf 17 19 separator 0.42646092 ¶ 310 312 W4245437313.pdf 17 20 table 0.49874526 2009 312 317 W4245437313.pdf 17 21 text 0.9236713 "Hashtag volume.The volume of usage a particular hashtag receives is not predictive of a party's/candidates vote share." 317 456 W4245437313.pdf 17 22 separator 0.98670924 ¶ 458 460 W4245437313.pdf 17 23 contact 0.8438663 "Erik Tjong Kim Sang and Johan Bos" 460 500 W4245437313.pdf 17 24 table 0.51869905 "2011 Dutch Senate ElectionsFebruary 16th" 500 546 W4245437313.pdf 17 25 separator 0.9271463 ¶ 547 549 W4245437313.pdf 17 26 table 0.59066516 2011 549 554 W4245437313.pdf 17 27 title 0.40747035 Volume 554 562 W4245437313.pdf 17 28 table 0.34651583 ¶ 562 563 W4245437313.pdf 17 29 title 0.59465575 Based 563 569 W4245437313.pdf 17 30 text 0.4216945 . 569 570 W4245437313.pdf 17 31 separator 0.63561434 ¶ 570 572 W4245437313.pdf 17 32 text 0.93373066 "Sentiment Based.A wide swing in terms of MAE. 17% in some cases." 572 649 W4245437313.pdf 17 33 separator 0.9603312 ¶ 649 651 W4245437313.pdf 17 34 contact 0.8700578 "Andranik Tumasjan, Timm O. Sprenger, Philipp G. Sandner, Isabell M. Welpe" 651 746 W4245437313.pdf 17 35 table 0.5774385 "2009 German Federal ElectionAugust 13th - September 19th 2009" 746 816 W4245437313.pdf 17 36 title 0.5740722 "Sentiment Based" 816 834 W4245437313.pdf 17 37 text 0.556399 . 834 835 W4245437313.pdf 17 38 separator 0.7486055 ¶ 835 837 W4245437313.pdf 17 39 text 0.9748293 "Volume Based.Raw volume based model was able to predict election result with a MAE of +/- 1.65%" 837 950 W4245437313.pdf 17 40 separator 0.98336875 ¶ 950 952 W4245437313.pdf 17 41 paratext 0.82124656 12 952 955 W4245437313.pdf 17 42 separator 0.9920081 ¶ 955 957 W4245437313.pdf 17 0 paratext 0.96651757 168 0 3 W2969922999.pdf 1 1 separator 0.97492075 ¶ 3 5 W2969922999.pdf 1 2 title 0.8644951 "PHYSICAL EDUCATION OF STUDENTSA" 8 48 W2969922999.pdf 1 3 text 0.9840523 "s a result, the aim of this study was to investigate effects of Wingate-based HIIT on aerobic and anaerobic performances of kick boxers." 48 190 W2969922999.pdf 1 4 separator 0.9958549 ¶ 190 192 W2969922999.pdf 1 5 title 0.9898065 Material and Method Participants 192 227 W2969922999.pdf 1 6 separator 0.98633903 ¶ 229 231 W2969922999.pdf 1 7 text 0.9994072 "Twenty-three male kick boxer (age 19.39 ± 0.72 y, body mass 74.14 ± 6.22 kg, height 177.95 ± 5.29 cm) voluntarily participated in this study. Participants were informed about the study in detail. All participants were told to refrain from strenuous training, food consumption 2 hours before the experiment, not to change their food habits and consume alcohol." 231 594 W2969922999.pdf 1 8 separator 0.9952 ¶ 595 597 W2969922999.pdf 1 9 title 0.9776235 Study design 597 610 W2969922999.pdf 1 10 text 0.9995535 "Experimental study design was used. 24 male kick box athletes who regularly trained voluntarily participated in this study. They were randomly divided into two groups: experimental and control. As well as their training routine, experimental group carried out Wingate-based HIIT 3 times per week with 1 day intervals for two weeks. Each training session involved a 10 min warm-up followed by a HIT program consisting of 4-5x30 s all-out sprints with a 4 min recovery. A 5 min cool down period was then performed. Body fat percentages, aerobic and anaerobic performances of the athletes were evaluated before and after the study. Pre and post tests were carried out 72 hours before and 48 hours after the training, respectively. All participant followed the same diet throughout the study." 610 1401 W2969922999.pdf 1 11 separator 0.9955511 ¶ 1402 1404 W2969922999.pdf 1 12 title 0.9314092 Study protocolHeight 1404 1425 W2969922999.pdf 1 13 text 0.77690655 , 1425 1426 W2969922999.pdf 1 14 title 0.59547186 body mass 1426 1436 W2969922999.pdf 1 15 text 0.9906872 "index (BMI), body fat weight, body fat percentage (BFP), aerobic capacity (VO2 max), anaerobic capacity, were measured before and after the training. To find the aerobic strength of the subjects, 20m shuttle run test was applied. All-out 30s WanT was applied to determine anaerobic performance of the athletes. Height was measured with a stadiometer (Holtain, England) and body mass was measured with Jowan Segmental Body Composition Analyzer (Korea) to the nearest 100 gr." 1436 1914 W2969922999.pdf 1 16 separator 0.99613917 ¶ 1914 1916 W2969922999.pdf 1 17 title 0.99125093 High Intensity Interval Training Program 1916 1957 W2969922999.pdf 1 18 text 0.99844736 "As well as their training routine, experimental group carried out Wingate-based HIIT with a resistance equal to %7.5 of body weight 3 times per week for two weeks. Athletes carried out four HIIT (4X30s) during the first week and 5 repetition (5X30s) during the second week." 1957 2233 W2969922999.pdf 1 19 separator 0.9952121 ¶ 2233 2235 W2969922999.pdf 1 20 title 0.9891845 Control Group Training Program 2235 2266 W2969922999.pdf 1 21 text 0.9984884 "Control group practiced typical kickbox training for 3 days with 1 day intervals for two weeks. During the first and second weeks of the training plan a and plan b were performed, respectively. Athletes used all the protective materials that are used during the competition." 2266 2543 W2969922999.pdf 1 22 separator 0.86946106 ¶ 2544 2546 W2969922999.pdf 1 23 text 0.99946505 "Plan a: After 20 minutes of warm-up, athletes performed 5 different technique combinations specific to kickbox competitions for 2 minutes with 1 min intervals. Then, athletes performed 3 different games specific to kickbox competition in order to improve distance control for 2 minutes. Lastly, athletes were paired and carried out 3 round simulated kickbox fight." 2546 2914 W2969922999.pdf 1 24 separator 0.72112846 ¶ 2918 2920 W2969922999.pdf 1 25 text 0.99956566 "Plan b: athletes performed the same program as the first week with increased number of repetitions and content of the techniques. Following a 20 min warm-up, athletes applied 7 different combinations of attack and defense techniques. Combinations lasted 2 min with 1 min intervals. Then, 5 X 2 min imaginary workout was carried out with 1 min intervals. At last, athletes were paired and carried out 3 round simulated kickbox fight." 2920 3356 W2969922999.pdf 1 26 separator 0.9962532 ¶ 3365 3367 W2969922999.pdf 1 27 title 0.98915905 Statistical Analysis 3367 3388 W2969922999.pdf 1 28 text 0.99914694 "Descriptive statistic test was used to show mean and standard deviation of the variables. The differences obtained from two groups were evaluated inter and intra-group. Mann Whitney-U Test was used to determine the differences between two groups. Wicoxon Signed Rank Test was used to determine intra-group differences. Statistical analysis was carried out with SPSS 22 and p value was set at p<0.05." 3388 3790 W2969922999.pdf 1 29 separator 0.9952252 ¶ 3790 3792 W2969922999.pdf 1 30 title 0.7570944 Results 3792 3800 W2969922999.pdf 1 31 text 0.99719954 "Table 1 presents anthropometric profile of the athletes.Table 2 presents body mass, body fat percentage, Peak Power (W/kg), Mean Power (W/kg), Minimum Power (W/kg) and predicted VO 2max of the kick box athletes." 3800 4016 W2969922999.pdf 1 32 separator 0.68475235 ¶ 4017 4019 W2969922999.pdf 1 33 text 0.99902654 "When the pre-test results presented by both groups were compared, there was no difference (p>0.05). Accordingly, differences between groups are as follow: body mass (z= -0.291, p= 0.771), body fat percentages (Z= -0.355, p= 0.722), Peak Power (Z= -1.743, p= 0.081), Mean Power (Z= -1.906, p= 0.057), Minimum Power (Z= -0.775, p= 0.438), and predicted VO 2max (Z=0.065, p= 0.945). Nevertheless, significant differences were found between both groups in PP, MP (p<0.05) after 2 weeks of HIIT while there was no difference in body mass, body fat percentage and predicted VO 2max. Accordingly, differences between groups are as follow: body mass (Z= -0.071, p= 0.776), body fat percentage (Z= -0.797, p= 0.426), Peak Power (Z= -3.22, p= 0.001*), Mean Power (Z= -2.68, p= 0.008*), Minimum power (Z= -2.00, p= 0.045*), estimated VO 2max (Z=-1,03, p= 0.302)." 4019 4886 W2969922999.pdf 1 34 separator 0.99679005 ¶ 4887 4889 W2969922999.pdf 1 35 title 0.9815199 Table 1. Anthropometric profile of kick boxers 4889 4937 W2969922999.pdf 1 36 separator 0.59390396 ¶ 4938 4940 W2969922999.pdf 1 37 table 0.99417895 "Variable (n=24) Mean±SD Age (y) 19.39 ± 0.72 Height (cm) 177.95 ± 5.29 Weight (kg) 74.14 ± 6.22 Body fat percentage (%) 11.96 ± 3.27" 4940 5081 W2969922999.pdf 1 0 paratext 0.8241895 359 0 3 W3115271997.pdf 3 1 title 0.9609854 Kekuatan Hukum Alat Bukti Keterangan Saksi Yang Sedarah Dengan Terdakwa Dalam Proses 3 91 W3115271997.pdf 3 2 separator 0.6974864 ¶ 92 94 W3115271997.pdf 3 3 title 0.9838126 Pembuktian Di Pengadilan 94 120 W3115271997.pdf 3 4 separator 0.9250152 ¶ 122 124 W3115271997.pdf 3 5 title 0.99006134 C. HASIL PENELITIAN DAN PEMBAHASAN 125 160 W3115271997.pdf 3 6 separator 0.99258983 ¶ 162 164 W3115271997.pdf 3 7 text 0.9989793 "Arti umum dari kata “saksi” adalah seorang yang memberikan keterangan untuk membuktikan keterangan suat u peristiwa. Keterangan saksi adalah salah satu alat bukti dalam perkara pidana yang berupa keterangan saksi mengenai suatu peristiwa pidana yang ia dengar sendiri, ia lihat sendiri dan ia alami sendiri dengan menyebut alasan dari pengetahuannya itu (Pasal 1 butir 27 KUHAP)." 164 557 W3115271997.pdf 3 8 separator 0.9457502 ¶ 559 561 W3115271997.pdf 3 9 text 0.9921972 "Umumnya semua orang dapat menjadi saksi. Kekecualian menjadi saksi tercantum dalam Pasal 168 KUHAP :" 561 666 W3115271997.pdf 3 10 separator 0.6673459 ¶ 667 669 W3115271997.pdf 3 11 text 0.89107764 "1. Keluarga sedarah atau semenda adalam garis lurus ke atas atau ke bawah sampai derajat ketiga dari terdakwa atau yang bersama -sama sebag ai terdakwa; 2. Saudara dari terdakwa atau yang bersama -sama sebagai terdakwa, saudara ibu atau saudara bapak, juga mereka yang mempunyai hubungan karena perkawinan dan anak -anak saudara terdakwa sampai derajat ketiga; 3. Suami atau istri terdakwa meskipun sudah bercerai atau yang bersama -sama sebagai terdakwa (And" 669 1153 W3115271997.pdf 3 12 bibliography 0.41519415 i Ham 1153 1158 W3115271997.pdf 3 13 text 0.4743091 zah 1158 1161 W3115271997.pdf 3 14 bibliography 0.5251847 . 200 9:26 1161 1171 W3115271997.pdf 3 15 text 0.66845554 8). 1171 1174 W3115271997.pdf 3 16 separator 0.9815141 ¶ 1176 1178 W3115271997.pdf 3 17 text 0.99780846 "Pengecualian dapat dilakukan apabila dari mereka menghendaki untuk disumpah dan disetujui oleh Penuntut Umum dan terdakwa seperti tercantum pada Pasal 169 ayat (1) KUHAP. Apabila sa ksi dari keluarga terdakwa bersedia untuk di sumpah maka keterangan yang ia berikan dapat dinilai sebagai alat bukti, dan keterangan tersebut dapat dipersamakan dengan alat bukti saksi yang sah lainnya." 1178 1575 W3115271997.pdf 3 18 separator 0.9865763 ¶ 1577 1579 W3115271997.pdf 3 19 text 0.9983159 "Mengenai pertimbangan saksi yang masih keluarga terda kwa disumpah atau tidak bahwa sebelumnya Hakim menanyakan terlebih dahulu kepada saksi tersebut, apakah ingin mengundurkan diri atau bersedia untuk di sumpah. Apabila saksi tersebut memilih untuk tidak disumpah maka melihat dari keterangan saksi lainnya ap akah ada persesuaian, dan keterangan saksi yang tidak disumpah dapat ditambahkan sebagai petunjuk untuk menguatkan keyakinan hakim." 1579 2037 W3115271997.pdf 3 20 separator 0.9905782 ¶ 2039 2041 W3115271997.pdf 3 21 text 0.9986661 "Pada perkara Nomor 132 / Pid.Sus / 2015 / PN.Smn, saksi -saksi yang diajukan oleh Jaksa Penuntut Umum yang berjumlah 9 orang, dua orang dari saksi tersebut adalah anggota keluarga dari terdakwa yaitu yang berinisial (My) dan (Dw), saksi tersebut merupakan anak dari terdakwa (Ar). Namun sesuai dengan ketentuan Pasal 169 ayat (1) KUHAP, maka saksi tersebut dapat memberi keterangan pada persidangan karena saksi tersebut telah bersedia memberikan keterangan di bawah sumpah dan penuntut umum serta terdakwa menyetujuinya." 2041 2583 W3115271997.pdf 3 22 separator 0.9725553 ¶ 2585 2587 W3115271997.pdf 3 23 text 0.99880797 "Saksi dari anggota keluarga yaitu (My) dan (Dw) yang merupakan anak dari terdakwa telah memenuhi syarat sah menjadi seorang saksi dan keterangan yang diberikannya bersesuaian dengan saksi -saksi yang lain sehingga merupakan alat bukti yang sah dan dapat dipersamakan dengan alat bukti saksi yang lain. Saksi dari anggota keluarga yaitu (My) dan (Dw) sudah sesuai dengan ke tentuan Pasal 160 ayat (3) KUHAP, Pasal 1 angka 27 KUHAP serta Pasal 185 ayat (1) KUHAP." 2587 3065 W3115271997.pdf 3 24 separator 0.985518 ¶ 3067 3069 W3115271997.pdf 3 25 text 0.9952654 "Berdasarkan keterangan saksi pada perkara Nomor: 132 / Pid.Sus / 2015 / PN.Smn, masing -masing dari 9 orang saksi termasuk anak dari terdakwa yang berinisial (My) dan ( Dw) telah memenuhi syarat sah menjadi seorang saksi, meliputi syarat formal dan syarat materiil." 3069 3344 W3115271997.pdf 3 26 separator 0.99567664 ¶ 3346 3348 W3115271997.pdf 3 27 title 0.9785476 a. Syarat Formal 3348 3365 W3115271997.pdf 3 28 separator 0.99573284 ¶ 3367 3369 W3115271997.pdf 3 29 text 0.9987952 "Bahwa keterangan saksi hanya dapat dianggap sah, apabila diberikan di bawah sumpah sebagaimana telah diatur dalam Pasal 160 ayat (3) KUHAP." 3369 3512 W3115271997.pdf 3 30 separator 0.69345605 ¶ 3513 3515 W3115271997.pdf 3 31 text 0.99876934 Keter angan saksi yang tidak di bawah sumpah hanya boleh dipergunakan sebagai 3515 3593 W3115271997.pdf 3 0 paratext 0.7445049 Retraction 0 10 W4389989374.pdf 0 1 separator 0.7458809 ¶ 10 12 W4389989374.pdf 0 2 title 0.944727 "Retracted: Sports Augmented Cognitive Bene fits: An fMRI Study of Executive Function with Go/NoGo Task" 12 116 W4389989374.pdf 0 3 separator 0.5091861 116 117 W4389989374.pdf 0 4 title 0.85082835 ¶ Neural Plasticity 117 136 W4389989374.pdf 0 5 separator 0.71999604 ¶ 136 138 W4389989374.pdf 0 6 paratext 0.98109436 Received 19 December 2023; Accepted 19 December 2023; Published 20 December 2023 138 219 W4389989374.pdf 0 7 separator 0.8286766 ¶ 219 221 W4389989374.pdf 0 8 paratext 0.96524596 "Copyright ©2023 Neural Plasticity. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited." 221 473 W4389989374.pdf 0 9 separator 0.99348897 ¶ 473 475 W4389989374.pdf 0 10 text 0.98783267 "This article has been retracted by Hindawi following an investi- gation undertaken by the publisher [1]. This investigation hasuncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: " 475 724 W4389989374.pdf 0 11 separator 0.5714751 ¶ 724 725 W4389989374.pdf 0 12 text 0.9039958 "(1) Discrepancies in scope (2) Discrepancies in the description of the research reported(3) Discrepancies between the availability of data and the research described (4) Inappropriate citations (5) Incoherent, meaningless and/or irrelevant content included in the article (6) Manipulated or compromised peer review" 725 1052 W4389989374.pdf 0 13 separator 0.90617687 ¶ 1052 1054 W4389989374.pdf 0 14 text 0.9961613 "The presence of these indicators undermines our con fidence in the integrity of the article ’s content and we cannot, therefore, vouch for its reliability. Please note that this notice is intended solely to alert readers that the content of this article is unreliable.We have not investigated whether authors were aware of orinvolved in the systematic manipulation of the publicationprocess." 1054 1451 W4389989374.pdf 0 15 separator 0.8580187 ¶ 1451 1453 W4389989374.pdf 0 16 text 0.99924433 "In addition, our investigation has also shown that one or more of the following human-subject reporting requirementshas not been met in this article: ethical approval by an Institu-tional Review Board (IRB) committee or equivalent, patient/participant consent to participate, and/or agreement to publishpatient/participant details (where relevant)." 1453 1804 W4389989374.pdf 0 17 separator 0.92617726 ¶ 1804 1806 W4389989374.pdf 0 18 text 0.9979656 "Wiley and Hindawi regrets that the usual quality checks did not identify these issues before publication and have since putadditional measures in place to s afeguard research integrity." 1806 1994 W4389989374.pdf 0 19 separator 0.92602456 ¶ 1994 1996 W4389989374.pdf 0 20 text 0.99372715 "We wish to credit our own Research Integrity and Research Publishing teams and anonymous and named externalresearchers and research integrity experts for contributing tothis investigation.The corresponding author, as the representative of all authors, has been given the opportunity to register their agree-ment or disagreement to this retraction. We have kept a record of any response received." 1996 2398 W4389989374.pdf 0 21 separator 0.9965556 ¶ 2398 2400 W4389989374.pdf 0 22 paratext 0.49758014 Reference 2400 2410 W4389989374.pdf 0 23 title 0.52164423 s 2410 2411 W4389989374.pdf 0 24 separator 0.9815194 ¶ 2411 2413 W4389989374.pdf 0 25 bibliography 0.99692845 "[1] Q. Ding, L. Huang, J. Chen et al., “Sports Augmented Cognitive Benefits: An fMRI Study of Executive Function with Go/NoGo Task, ”Neural Plasticity , vol. 2021, Article ID 7476717, 6 pages," 2413 2609 W4389989374.pdf 0 26 separator 0.7113787 ¶ 2609 2611 W4389989374.pdf 0 27 paratext 0.9259949 "2021.Hindawi Neural Plasticity Volume 2023, Article ID 9867463, 1 page https://doi.org/10.1155/2023/9867463" 2611 2725 W4389989374.pdf 0 28 separator 0.9964813 ¶ 2725 2727 W4389989374.pdf 0 0 paratext 0.9639748 L. F. T. Mukwa et al . 0 23 W2009523693.pdf 9 1 separator 0.92264503 ¶ ¶ 24 30 W2009523693.pdf 9 2 paratext 0.96969193 656 31 35 W2009523693.pdf 9 3 title 0.5476066 Annexes 36 44 W2009523693.pdf 9 4 separator 0.86113644 ¶ ¶ 46 52 W2009523693.pdf 9 5 title 0.81161183 (a) 52 56 W2009523693.pdf 9 6 separator 0.5394959 ¶ ¶ 57 63 W2009523693.pdf 9 7 title 0.5649791 (a & b) 63 71 W2009523693.pdf 9 8 separator 0.41018257 ¶ ¶ 73 79 W2009523693.pdf 9 9 text 0.40930307 (b 79 82 W2009523693.pdf 9 10 title 0.50782204 ) 82 83 W2009523693.pdf 9 11 separator 0.9944992 ¶ 84 86 W2009523693.pdf 9 12 caption 0.9580407 "Figure 1. Molecular detection of Banana bunchy top virus on 54 samples from Bas Congo and urban and péri urban Ki n- shasa province. Thesites surveyed were:" 86 247 W2009523693.pdf 9 13 text 0.96959966 "( a) In Bas Congo: Kasavubu-lukula, kinzita -lukula, patuzemba-lukula, kok o- lo-lukula, 4janvier -lukula ,mawusa -lukula , inera luki, Luila, M’vuazi 1, Kisantu, Madimba, Ki nzokimosi, Mbanzangungu, Mwenge - lukula, ELPV lukula." 247 482 W2009523693.pdf 9 14 caption 0.68751776 ( b) In Kin 482 494 W2009523693.pdf 9 15 text 0.78835195 shasa 494 499 W2009523693.pdf 9 16 caption 0.72956693 urban and peri urban: 499 521 W2009523693.pdf 9 17 text 0.89182425 Selembao 521 530 W2009523693.pdf 9 18 caption 0.6005622 , 530 531 W2009523693.pdf 9 19 text 0.83287865 KindeleI Montnga fula 531 553 W2009523693.pdf 9 20 caption 0.5229499 , 553 554 W2009523693.pdf 9 21 text 0.781589 Cité verte 554 565 W2009523693.pdf 9 22 caption 0.59330064 , 565 566 W2009523693.pdf 9 23 text 0.9109975 N 566 568 W2009523693.pdf 9 24 caption 0.53127074 ’ 568 569 W2009523693.pdf 9 25 text 0.9037608 "Dj ili secomaf, djili brasserie, Menkao, Bandalungwa, Kalamu, Kingabwa, Malueka et Kinsuka pompage" 569 670 W2009523693.pdf 9 26 caption 0.5363413 , 670 671 W2009523693.pdf 9 27 text 0.90962577 Kasangulu 671 681 W2009523693.pdf 9 28 caption 0.55486965 , 681 682 W2009523693.pdf 9 29 text 0.74601185 Maluku . 682 691 W2009523693.pdf 9 30 separator 0.99599266 ¶ 786 788 W2009523693.pdf 9 0 paratext 0.97351944 "ISSN: 2320 -5407 Int. J. Adv. Res. 7(5), 858-862 861" 0 89 W2955954846.pdf 3 1 separator 0.9746938 ¶ 90 92 W2955954846.pdf 3 2 title 0.9934052 Table 1:-Intergroup Comparison of Pre menarche and Menarche Group 93 160 W2955954846.pdf 3 3 separator 0.9852605 "¶ ¶" 162 172 W2955954846.pdf 3 4 title 0.8917405 Discussion :- 172 186 W2955954846.pdf 3 5 separator 0.963591 ¶ 187 189 W2955954846.pdf 3 6 text 0.99604875 "The aim of the study was to compare the fitness level of female sports players in pre menarche and menarche phase. The fitness tests were performed among 100 female sports players, out of which 50 were in pre menarche phase and 50 in menarche phase. Results showed there was a significant difference in the muscle strength, endurance, flexibility and agility . But there was no significant difference in the cardiovascular endurance. Thus, we reject the null hypothesis.Thus menarche has certain effects on the physical fitness of females." 189 745 W2955954846.pdf 3 7 separator 0.5185834 747 748 W2955954846.pdf 3 8 text 0.98224765 "¶ According to Goswami in 2014, the pubertal growth and hence the physical fitness is directly and indirectly affected by the hormonal changes during this period.(1) Among the several fitness variables body composition, muscle strength and bone development have been found to be mostly affected by the puberty.(10)" 748 1072 W2955954846.pdf 3 9 separator 0.96764654 ¶ 1074 1076 W2955954846.pdf 3 10 text 0.9972412 "According to Fard and colleagues in 2017, significant difference in physical fitness level in early and late puberty was due to natural grow and increase of muscle size and also, indicative of the lack of impact of puberty factor in drop of physical fitness level.(2)" 1076 1351 W2955954846.pdf 3 11 separator 0.55440414 ¶ 1353 1355 W2955954846.pdf 3 12 text 0.9861335 "¶ According to Fard and colleagues in 2017, significant difference in physical fitness level in early an d late puberty was due to natural grow and increase of muscle size and also, indicative of the lack of impact of puberty factor in drop of physical fitness level.(2) ¶ Estrogen up regulates the ability of muscles to contract by about 10%, with a peak in st rength just before ovulation (Day MA in 2015). Improvements of heart size with greater aerobic fitness should occur due to increase in lung size, skeletal muscle mass, musclecapillarization. (1) ¶ Menarcheal physical activity participation would be positiv ely associated with lean mass and strength development. (3) ¶ Puberty alters the aerobic fitness by increasing body size, dimension of the heart, lungs, muscles and circulatory system.(9) ¶ The key factors of physical fitness development are growth, developm ent, and the maturation rate ( Matejek in 2013)." 1357 2328 W2955954846.pdf 3 13 table 0.9778498 "(4) 13.68 16.86 23.38 24.24 81.18 125 15.18 17.94 26.64 26.6 84.52 125.36 020406080100120140 Pre Post SU QJ VJ SR CARDIOPre Menarche Menarche" 2328 2493 W2955954846.pdf 3 0 paratext 0.9633365 "Publish with BioMed Central and every scientist can read your work free of charge" 0 87 W2124590669.pdf 6 1 separator 0.59784347 ¶ 87 89 W2124590669.pdf 6 2 paratext 0.67697394 """BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime."" Sir Paul Nurse, Cancer Research UK" 89 257 W2124590669.pdf 6 3 separator 0.84162104 ¶ 257 259 W2124590669.pdf 6 4 paratext 0.689688 Your research papers will be: 259 289 W2124590669.pdf 6 5 text 0.47592342 ¶ 289 291 W2124590669.pdf 6 6 paratext 0.6678183 available free of charge to the entire biomedical community 291 351 W2124590669.pdf 6 7 text 0.53513175 ¶ 351 353 W2124590669.pdf 6 8 paratext 0.6124736 peer reviewed and published immediately upon acceptance 353 409 W2124590669.pdf 6 9 text 0.508977 ¶ 409 411 W2124590669.pdf 6 10 paratext 0.8626515 "cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.aspBioMed centralFrontiers in Zoology 2009, 6:25 http://www.frontiersinz oology.com/content/6/1/25" 411 674 W2124590669.pdf 6 11 separator 0.7465858 ¶ 674 676 W2124590669.pdf 6 12 paratext 0.98824495 Page 7 of 7 676 688 W2124590669.pdf 6 13 separator 0.9826992 ¶ 688 690 W2124590669.pdf 6 14 bibliography 0.64811283 (page number 690 703 W2124590669.pdf 6 15 paratext 0.49042094 not for 703 711 W2124590669.pdf 6 16 bibliography 0.6326914 711 712 W2124590669.pdf 6 17 paratext 0.47939885 citation purpose 712 728 W2124590669.pdf 6 18 bibliography 0.9830658 "s)4. 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Learn Behav 2006, 34(4): 366-73." 1206 1340 W2124590669.pdf 6 25 separator 0.94440943 ¶ 1340 1342 W2124590669.pdf 6 26 bibliography 0.99800307 "8. Wiltschko W, Wiltschko R: Magnetoreception in birds: two receptors for two different tasks. J Ornithol 2007, 148:61-76." 1342 1470 W2124590669.pdf 6 27 separator 0.9578744 ¶ 1470 1472 W2124590669.pdf 6 28 bibliography 0.9978003 "9. Wiltschko W: On the effect of static magnetic fields on the migratory orientation of the robin (Erithacus rubecula). Z Tierpsychol 1968, 25(5): 537-558." 1472 1635 W2124590669.pdf 6 29 separator 0.94558364 ¶ 1635 1637 W2124590669.pdf 6 30 bibliography 0.9979596 "10. Walcott C, Green RP: Orientation of homing pigeons altered by a change in the direction of an applied magnetic field. Sci- ence 1974, 184(133): 180-182." 1637 1800 W2124590669.pdf 6 31 separator 0.9615458 ¶ 1800 1802 W2124590669.pdf 6 32 bibliography 0.99799633 "11. Freire R, Munro UH, Rogers LJ, Wiltschko R, Wiltschko W: Chick- ens orient using a magnetic compass. Curr Biol 2005, 15(16): R620-621." 1802 1948 W2124590669.pdf 6 33 separator 0.94620645 ¶ 1948 1950 W2124590669.pdf 6 34 bibliography 0.99809176 "12. Wiltschko W, Freire R, Munro U, Ritz T, Rogers L, Thalau P, Wilt- schko R: The magnetic compass of domestic chickens, Gallus gallus. J Exp Biol 2007, 210(Pt 13): 2300-2310." 1950 2134 W2124590669.pdf 6 35 separator 0.96173406 ¶ 2134 2136 W2124590669.pdf 6 36 bibliography 0.9980066 "13. Voss J, Keary N, Bischof HJ: The use of the geomagnetic field for short distance orientation in zebra finches. Neuroreport 2007, 18(10): 1053-1057." 2136 2295 W2124590669.pdf 6 37 separator 0.9502445 ¶ 2295 2297 W2124590669.pdf 6 38 bibliography 0.9979385 "14. Beason RC, Nichols JE: Magnetic orientatio n and magnetically sensitive material in a tr ansequatorial migratory bird. Nature 1984, 309:151-153." 2297 2452 W2124590669.pdf 6 39 separator 0.9467359 ¶ 2452 2454 W2124590669.pdf 6 40 bibliography 0.9977895 "15. Williams MN, Wild JM: Trigeminally innervat ed iron-containing structures in the beak of ho ming pigeons, and other birds. Brain Res 2001, 889(1-2): 243-246." 2454 2621 W2124590669.pdf 6 41 separator 0.968186 ¶ 2621 2623 W2124590669.pdf 6 42 bibliography 0.99798995 "16. Fleissner G, Holtkamp-Rotzler E, Hanzlik M, Winklhofer M, Fleissner G, Petersen N, Wiltschko W: Ultrastructural analysis of a puta- tive magnetoreceptor in th e beak of homing pigeons. J Comp Neurol 2003, 458(4): 350-360." 2623 2858 W2124590669.pdf 6 43 separator 0.95307267 ¶ 2858 2860 W2124590669.pdf 6 44 bibliography 0.99802774 "17. Kirschvink JL, Gould JL: Biogenic magnetite as a basis for mag- netic field detection in animals. Biosystems 1981, 13(3): 181-201." 2860 3000 W2124590669.pdf 6 45 separator 0.9597708 ¶ 3000 3002 W2124590669.pdf 6 46 bibliography 0.99795604 "18. Fleissner G, Stahl B, Thalau P, Falkenberg G, Fleissner G: A novel concept of Fe-mineral-based magnetoreception: histological and physicochemical data from the upper beak of homing pigeons. Naturwissenschaften 2007, 94(8): 631-642." 3002 3247 W2124590669.pdf 6 47 separator 0.95701605 ¶ 3247 3249 W2124590669.pdf 6 48 bibliography 0.99793977 "19. Beason R, Semm P: Does the avian ophthalmic nerve carry magnetic navigational information? J Exp Biol 1996, 199(Pt 5):1241-1244." 3249 3389 W2124590669.pdf 6 49 separator 0.9640569 ¶ 3389 3391 W2124590669.pdf 6 50 bibliography 0.9975948 "20. Schulten K, Windemuth A: Model for a physiological magnetic compass. In Biophysical Effects of Steady Magnetic Fields Edited by: Maret G, Boccara N, J K. New Yo rk, Berlin, Heidelberg: Springer; 1986:99-106." 3391 3612 W2124590669.pdf 6 51 separator 0.96540964 ¶ 3613 3615 W2124590669.pdf 6 52 bibliography 0.9979432 "21. Ritz T, Adem S, Schulten K: A model for photoreceptor-based magnetoreception in birds. Biophys J 2000, 78(2): 707-718." 3615 3743 W2124590669.pdf 6 53 separator 0.96142566 ¶ 3743 3745 W2124590669.pdf 6 54 bibliography 0.9977544 "22. Thalau P, Ritz T, Stapput K, Wiltschko R, Wiltschko W: Magnetic compass orientation of migrator y birds in the presence of a 1.315 MHz oscillating field. Naturwissenschaften 2005, 92(2): 86-90." 3745 3952 W2124590669.pdf 6 55 separator 0.9672542 ¶ 3952 3954 W2124590669.pdf 6 56 bibliography 0.9978854 "23. Ritz T, Wiltschko R, Hore PJ, Rodgers CT, Stapput K, Thalau P, Tim- mel CR, Wiltschko W: Magnetic compass of birds is based on a molecule with optimal directional sensitivity. Biophys J 2009, 96(8): 3451-7." 3954 4174 W2124590669.pdf 6 57 separator 0.95631 ¶ 4174 4176 W2124590669.pdf 6 58 bibliography 0.9979675 "24. Ritz T, Thalau P, Phillips JB, Wiltschko R, Wiltschko W: Resonance effects indicate a radical-pair mechanism for avian magnetic compass. Nature 2004, 429(6988): 177-180." 4176 4358 W2124590669.pdf 6 59 separator 0.9655123 ¶ 4358 4360 W2124590669.pdf 6 60 bibliography 0.9979541 "25. Thalau P, Ritz T, Burda H, Wegner RE, Wiltschko R: The magnetic compass mechanisms of birds and rodents are based on dif- ferent physical principles. J R Soc Interface 2006, 3(9): 583-587." 4360 4560 W2124590669.pdf 6 61 separator 0.9657628 ¶ 4560 4562 W2124590669.pdf 6 62 bibliography 0.9979143 "26. Wegner RE, Begall S, Burda H: Magnetic compass in the cornea: local anaesthesia impairs orientation in a mammal. J Exp Biol 2006, 209(Pt 23): 4747-4750." 4562 4725 W2124590669.pdf 6 63 separator 0.9591389 ¶ 4725 4727 W2124590669.pdf 6 64 bibliography 0.9977384 "27. Sancar A: Structure and function of DNA photolyase and cryptochrome blue-light photoreceptors. Chem Rev 2003, 103(6): 2203-2237." 4727 4867 W2124590669.pdf 6 65 separator 0.9628556 ¶ 4867 4869 W2124590669.pdf 6 66 bibliography 0.99793935 "28. Bailey MJ, Chong NW, Xiong J, Cassone VM: Chickens' Cry2: molecular analysis of an avia n cryptochrome in retinal and pineal photoreceptors. FEBS Lett 2002, 513(2-3): 169-174.29. Haque R, Chaurasia SS, Wessel JH 3rd, Iuvone PM: Dual regulation of cryptochrome 1 mRNA expre ssion in chic ken retina by light and circadian oscillators. Neuroreport 2002, 13(17): 2247-2251." 4869 5261 W2124590669.pdf 6 67 separator 0.9731498 ¶ 5261 5263 W2124590669.pdf 6 68 bibliography 0.9977749 "30. Moller A, Sagasser S, W iltschko W, Schierwater B: Retinal crypto- chrome in a migratory passerine bird: a possible transducer for the avian magnetic compass. Naturwissenschaften 2004, 91(12): 585-588." 5263 5478 W2124590669.pdf 6 69 separator 0.9743271 ¶ 5478 5480 W2124590669.pdf 6 70 bibliography 0.9978665 "31. Mouritsen H, Janssen-Bienhold U, Liedvogel M, Feenders G, Stal- leicken J, Dirks P, Weiler R: Cryptochromes and neuronal-activ- ity markers colocalize in the re tina of migratory birds during magnetic orientation. Proc Natl Acad Sci USA 2004, 101(39): 14294-14299." 5480 5761 W2124590669.pdf 6 71 separator 0.96570647 ¶ 5761 5763 W2124590669.pdf 6 72 bibliography 0.997903 "32. Thoss F, Bartsch B: The human visual threshold depends on direction and strength of a weak magnetic field. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 2003, 189(10): 777-9." 5763 5958 W2124590669.pdf 6 73 separator 0.9544509 ¶ 5958 5960 W2124590669.pdf 6 74 bibliography 0.99765736 "33. Watanabe S, Bischof HJ: Effects of hippocampal lesions on acquisition and retention of spat ial learning in zebra finches. Behav Brain Res 2004, 155(1): 147-52." 5960 6130 W2124590669.pdf 6 75 separator 0.96953607 ¶ 6130 6132 W2124590669.pdf 6 76 bibliography 0.99793667 "34. Ericson PG, Anderson CL, Britton T, Elzanowski A, Johansson US, Kallersjo M, Ohlson JI, Pars ons TJ, Zuccon D, Mayr G: Diversifica- tion of Neoaves: integration of molecular sequence data and fossils. Biol Lett 2006, 2(4): 543-547." 6132 6377 W2124590669.pdf 6 0 paratext 0.9856038 Author Manuscript Author Manuscript Author Manuscript Author ManuscriptFarquharson et al. Page 9 0 96 W2736057678.pdf 8 1 separator 0.99350446 ¶ 96 98 W2736057678.pdf 8 2 title 0.9717275 Table 1 98 106 W2736057678.pdf 8 3 separator 0.99477744 ¶ 106 108 W2736057678.pdf 8 4 table 0.64523786 List of 33 drugs included in the SERS library. All were measured at 100 μg/mL. 108 187 W2736057678.pdf 8 5 separator 0.90977216 ¶ 187 189 W2736057678.pdf 8 6 table 0.98701936 "acetaminophen cannabidiol heroin meperidine naltrexone phenylbarbitol amobarbitol cocaine hydrocodone mescaline nicotine secobarbitol amphetamine codeine hydroxy-THC methadone oxazepam varenicline buprenorphine Δ9-THC ibuprofen methamphetamine oxycodone buproprion diazepam MDA methylphenidate oxymorphone caffeine fentanyl MDMA morphine phencyclidine" 189 551 W2736057678.pdf 8 7 separator 0.9910115 ¶ 551 553 W2736057678.pdf 8 8 paratext 0.9560383 J Anal Bioanal Tech . Author manuscript; available in PMC 2018 June 01. 553 625 W2736057678.pdf 8 0 paratext 0.98383176 3846 Human Molecular Genetics,2018,Vol. 27,No. 22 0 49 W2884309940.pdf 6 1 separator 0.99529773 ¶ 49 51 W2884309940.pdf 6 2 caption 0.98595655 "Figure 4. Assessment of ER stress in Col10a1 p.Tyr632stop MCDS mouse model. The cartilage growth plate extracts from three 21-day-old mice were analysed with qPCR for the expression of ( A)Bip,(B)Creld2and (C)ChopmRNAs. ( D) RT-PCR on cDNA drive form three pooled ribs growth plate extracts of 21-day-old mice to detect the unsliced form of Xbp1 (size =205 bp FL) or the active and spliced form of Xbp1 (Xbp1s) with the size of 179 bp ( −RT=minus reverse transcriptase control)." 51 534 W2884309940.pdf 6 3 separator 0.91853917 ¶ 534 536 W2884309940.pdf 6 4 caption 0.9959995 (E) The average rate of Xbp1 splicing from three independent samples for each genotype. ( F) A typical western blots of rib growth plate extracts at 3 weeks of age for 536 704 W2884309940.pdf 6 5 separator 0.945657 ¶ 704 706 W2884309940.pdf 6 6 caption 0.9690065 Bip,Creld2,Atf4 and cleaved and activated form of Atf6 αand Atf6 α(N),proteins.Coomassie blue-stained gel was used as loading control.( G–J) Quantification of ( G)B i p , 706 877 W2884309940.pdf 6 7 separator 0.6808349 ¶ 877 879 W2884309940.pdf 6 8 caption 0.91180235 (H)C r e l d 2 ,( I)A t f 4a n d( J )A t f 6 α(N) from three independent experiments.All statistical analyses by ANOVA.(*P<0.05,**P<0.01). 879 1018 W2884309940.pdf 6 9 paratext 0.7953835 Downloaded from https://academic.oup.com/hmg/article/27/22/3840/5053937 by guest on 17 May 2024 1018 1113 W2884309940.pdf 6 10 separator 0.996153 ¶ 1113 1115 W2884309940.pdf 6 0 table 0.99367404 20BRAFV600E RESISTANTIVCutaneousCT, TT, IT8056Back noduleTargeted21BRAFV600E RESISTANTIVCutaneousUnkwonn15070Right LegTargeted22BRAFV600E NAÏVEIVCutaneousNo treatment5545Metastatectomy left chest wallN/A23BRAF MUTANTIVCutaneousIT, TT, IT756Excision melanoma Targeted24BRAF wildtypeIVCutaneousIT5267Excision melanoma N/A25BRAFV600E RESISTANTIVCutaneousTT055Excision of skin lesion to scalpN/A26BRAFV600E RESISTANTIVCutaneousTT, IT054Subcutaneous lesion excision Targeted27BRAFV600E RESISTANTIVCutaneousTT, IT061Excision of Tumor deposits Targeted28BRAFL597P/NRASE153KIVCutaneousCT, IT075Excision of lesion to back regionWES29BRAFV600E NAÏVEIIICutaneousNo treatment074Metastatic deposits left Targeted30BRAFK601EIVCutaneousCT, IT038Ultrasound guided biopsy of N/A31BRAFV600E RESISTANTIVCutaneousTT, IT062Melanoma deposit right Targeted32BRAF wildtypeIVCutaneousIT062Excision lesion right lower limbN/A33BRAFV600E RESISTANTIVCutaneousTT, IT062Right legTargeted34BRAFV600E RESISTANTIVCutaneousUnkwonn071Electrochemotherapy with Targeted35BRAF WildtypeIVCutaneousCT, IT080Electrochemotherapy with N/A36BRAFV600E NAÏVEIVAcralIT, TT2639Metastectomy right thighWES37unknownIII?acral right foot No treatment systemic 10085Electrochemotherapy with N/A38KRASG12DIVAcralNo treatment071Excision lesion right neckWES39NRASQ61LIIICutaneousNo treatment2880Right Groin DissectionTargeted40BRAF wildtypeIIICutaneousNo treatment10554Left groin nodeTargeted41BRAF wildtype IIICutaneousNo treatment8563Right axillary dissectionWES42BRAFV600E NAÏVEIII to IV CutaneousTT8079Right axillary dissectionTargeted43BRAFV600E NAÏVEIIICutaneousNo treatment1074Dissection right inguinal lymph Targeted 0 2005 W4362538902.pdf 1 0 paratext 0.9157348 Full text (403.0 kB) 0 20 W2119612521.pdf 1 0 paratext 0.9846486 "Clin Case Rep. 2021;9:355–361. | 355 wileyonlinelibrary.com/journal/ccr3" 0 79 W4243534838.pdf 0 1 separator 0.9318368 ¶ 79 81 W4243534838.pdf 0 2 paratext 0.78752846 1 | 81 85 W4243534838.pdf 0 3 title 0.9887407 INTRODUCTION 85 98 W4243534838.pdf 0 4 separator 0.99451447 ¶ 98 100 W4243534838.pdf 0 5 text 0.999554 "Juvenile nasopharyngeal angiofibroma (JNA) is a tumor that occurs only in 0.05% of all head and neck tumors. We report a multisystemic approach combining study methods and col-laboration with a radiologist for a 16-year-old male patient, diagnosed with a JNA measuring 2 × 3 × 5 cm with retarded diagnosis who received endoscopic surgery management." 100 453 W4243534838.pdf 0 6 separator 0.8789746 ¶ 453 455 W4243534838.pdf 0 7 text 0.9995513 "Juvenile nasopharyngeal angiofibroma (JNA) was first described in 1897 by Chelius as a polyp that took place during the adolescence and early adulthood stage. This type of tumor occurs only in 0.05% of all head and neck tumors, it is benign, and as the name implies, it is installed in the nasopharynx, more specifically, in the sphenoid process of the palatine bone with the horizontal wing of vomer and on the roof of the pterygoid process of the sphenoid bone. Histologically, it is formed by a cylindrical and pavement epithelium with the characteristics of the epithelium found in the nasopharynx, below is a loose cellular tissue, and the neoformation itself is constituted by fibrous and highly" 455 1160 W4243534838.pdf 0 8 paratext 0.9829049 "Received: 24 August 2020 | Revised: 5 October 2020 | Accepted: 27 October 2020 DOI: 10.1002/ccr3.3529" 1160 1264 W4243534838.pdf 0 9 separator 0.9888579 ¶ 1266 1268 W4243534838.pdf 0 10 title 0.9893403 CASE REPORT 1268 1280 W4243534838.pdf 0 11 separator 0.9939564 ¶ 1280 1282 W4243534838.pdf 0 12 title 0.92920315 Juvenile nasopharyngeal angiofibroma in a male of 16 years old. 1282 1346 W4243534838.pdf 0 13 separator 0.9873912 ¶ 1347 1349 W4243534838.pdf 0 14 title 0.8268637 A case report 1349 1363 W4243534838.pdf 0 15 separator 0.94650245 ¶ 1363 1365 W4243534838.pdf 0 16 table 0.97960997 "Daniel Salame Waxman1,2 | Adelaido López Chavira2,3,4 | Martín Alberto Porras Jiménez2,3,5 | César López Hernández3,6 | Jorge Alberto Romo Magdaleno2,3,6 | Julio Eduardo López Montoy1" 1365 1567 W4243534838.pdf 0 17 separator 0.9694594 ¶ 1567 1569 W4243534838.pdf 0 18 paratext 0.9687428 "This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.© 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd." 1569 1851 W4243534838.pdf 0 19 contact 0.9789508 "1Department of Health Sciences, School of Medicine, Anahuac University Network, Naucalpan de Juarez, Mexico 2Undergraduate Internal Medical Teaching Department ABC Medical Center I.A.P., Centro Médico ABC, Mexico City, Mexico 3Department of Otolaryngology, Head and Neck Surgery, Universidad del Ejercito y Fuerza Aerea, Mexico City, Mexico 4Department of Otolaryngology, Head and Neck Surgery, Corporativo Hospital Satelite, Naucalpan, Mexico 5Department of Interventional Neuroradiology, Hospital Angeles Lomas, Huixquilucan, Mexico 6Department of Otolaryngology, Head and Neck Surgery, Hospital Central Militar, Miguel Hidalgo, Mexico" 1851 2519 W4243534838.pdf 0 20 separator 0.9679067 ¶ 2519 2521 W4243534838.pdf 0 21 contact 0.9560192 Correspondence 2521 2536 W4243534838.pdf 0 22 separator 0.7751358 ¶ 2536 2538 W4243534838.pdf 0 23 contact 0.9955318 Daniel Salame Waxman, Av Universidad Anáhuac 46, Lomas Anahuac, 52786 Naucalpan de Juárez, Méx. Naucalpan de Juarez PO BOX. 52786, Mexico.Email: drdanielsalame@gmail.com 2538 2708 W4243534838.pdf 0 24 title 0.8428462 Abstract 2708 2716 W4243534838.pdf 0 25 separator 0.99435645 ¶ 2716 2718 W4243534838.pdf 0 26 text 0.99906766 We present a multisystemic approach involving diverse specialists of a rare disease. Bringing into the perspective the importance of multidisciplinary work and complete patient knowledge in order to an adequate clinical practice and patient outcome. 2718 2968 W4243534838.pdf 0 27 separator 0.9966184 ¶ 2968 2970 W4243534838.pdf 0 28 title 0.97910416 KEYWORDS 2970 2979 W4243534838.pdf 0 29 separator 0.99506676 ¶ 2979 2981 W4243534838.pdf 0 30 text 0.9467008 benign head and neck tumor, endoscopic surgery, epistaxis, Juvenile nasopharyngeal angiofibroma 2981 3077 W4243534838.pdf 0 0 paratext 0.976233 "4 Vol:.(1234567890) Scientific Reports | (2022) 12:2312 | https://doi.org/10.1038/s41598-022-05670-5" 0 112 W4211009551.pdf 3 1 separator 0.7097397 ¶ 112 114 W4211009551.pdf 3 2 paratext 0.945 www.nature.com/scientificreports/ 114 148 W4211009551.pdf 3 3 text 0.69970864 "Using the generated ratio, a RNA input of 4 ng total human RNA was determined individually for each sam - ple for a second cDNA synthesis followed by 2nd qRT-PCR (confirmation for methodological reasons in this context, Fig. 2 " 148 381 W4211009551.pdf 3 4 caption 0.39368147 boxes in 381 389 W4211009551.pdf 3 5 text 0.45811576 darker grey). 389 403 W4211009551.pdf 3 6 separator 0.99375856 ¶ 403 405 W4211009551.pdf 3 7 text 0.9991071 "Modified cDNA synthesis—SuperScript III First -Strand Synthesis System. In order to sub- sequently perform gene expression analysis of human origin, only eukaryotic messenger RNA (mRNA) was reverse transcribed to cDNA by using the SuperScript® III First-Strand Synthesis System with Oligo (dT)20 prim - ers. As a result, pan-bacterial RNA and other human RNA species were excluded from further processing, mini- mizing the inhibition effects of those RNA species on the following reactions. According to the kit description, the amount of starting material can vary from 1 pg to 5 μg of RNA and the maximum input volume of RNA is 8 μl19. The amount of human RNA input was set to 4 ng per reaction. Using the concentration from repeated NanoDropTM measurements and the calculated 18S/16S ratio in each sample, the corresponding amount of meas- ured total RNA input was calculated, conforming to the maximum input volume of 8 μl. The RT was performed according to the manufacturer’s instructions19." 405 1425 W4211009551.pdf 3 8 separator 0.9903781 ¶ 1425 1427 W4211009551.pdf 3 9 text 0.9981839 "Pre-amplification—TaqMan® PreAmp Master Mix. To detect low abundance mRNA species, pre- amplification was required. We used TaqMan® PreAmp Master Mix (Thermo Fisher Scientific Baltics UAB, Vilnius, Lithuania) to increase the amount of specific cDNA targets, synthesized with the SuperScript® III First-Strand Synthesis System. According to the manufacturer, pre-amplification with this kit is linear when a minimum amount of cDNA molecules is present (minimum of 1–250 ng and Ct-values without pre-amplification should be < 35) and multiplex amplification can be performed by pooling up to 100 TaqMan® Gene Expression Assays. Pre-amplification was performed according to the TaqMan® PreAmp master mix kit protocol20. In the present work, 10 different TaqMan® Gene Expression Assays (ACTB, Hs01060665_g1; B2M, Hs00187842_m1; GUSB, Hs00939627_m1; MT-ATP6, Hs02596862_g1; PGK1, Hs00943178_g1; PP1A, Hs99999904_m1; RPL13A, Hs04194366_g1; RPLP0, Hs02992885_s1; TBP, Hs00427620_m1; YWHAZ, Hs01122445_g1) were utilized and pooled to enable the multiplex amplification of specific cDNA targets. Those are commonly used house-keeping genes already employed in other experimental set ups (www. genom ics- online. com)." 1427 2669 W4211009551.pdf 3 10 separator 0.9901837 ¶ 2669 2671 W4211009551.pdf 3 11 text 0.99586815 "Real-time quantitative reverse transcription polymerase chain reaction (qRT -PCR). Using dif- ferent sets of primers, two kinds of cDNAs were utilized for qRT-PCR: for human (18S rRNA, Hs99999901_g1) and pan-bacterial (16S rRNA, Ba04230899_s1) primer probe designs, cDNA from High-capacity cDNA reverse transcription kit was used, whereas for the primer probe designs representing the potential house-keeping genes (ACTB, B2M, GUSB, MT-ATP6, PGK1, PP1A, RPL13A, RPLP0, TBP, YWHAZ), SuperScriptTM III First-Strand Synthesis SuperMix synthesized, i.e. human cDNA with and without 14× pre-amplification was used for detec- tion of each of these genes in each sample. The qRT-PCR reaction contained TaqMan® Universal PCR Master Mix and one of the inventoried TaqMan® Gene Expression Assays for separate detection of transcripts. All meas-adjustment of RNA input to" 2671 3551 W4211009551.pdf 3 12 separator 0.91056055 ¶ 3552 3554 W4211009551.pdf 3 13 title 0.4254764 4 ng of hum an RNATask 3554 3577 W4211009551.pdf 3 14 math 0.4133995 II ¶ 3577 3582 W4211009551.pdf 3 15 table 0.41942367 Task IIII ksaTSample collec 3582 3610 W4211009551.pdf 3 16 math 0.43664294 / 3610 3611 W4211009551.pdf 3 17 table 0.38718027 g 3611 3612 W4211009551.pdf 3 18 math 0.43693057 415on ¶ 3612 3619 W4211009551.pdf 3 19 table 0.43172544 RNA isola 3619 3629 W4211009551.pdf 3 20 math 0.45960775 /g415 3629 3634 W4211009551.pdf 3 21 table 0.4082194 on 3634 3636 W4211009551.pdf 3 22 math 0.48656583 ¶ + 3637 3641 W4211009551.pdf 3 23 table 0.4443604 Qu alita 3641 3650 W4211009551.pdf 3 24 math 0.4909069 / 3650 3651 W4211009551.pdf 3 25 table 0.45555893 g415ve and quan 3651 3666 W4211009551.pdf 3 26 math 0.49120757 / 3666 3667 W4211009551.pdf 3 27 table 0.45307398 g415ta 3667 3673 W4211009551.pdf 3 28 math 0.47940776 / 3673 3674 W4211009551.pdf 3 29 table 0.51838624 g415ve analysis 3674 3689 W4211009551.pdf 3 30 separator 0.8829324 ¶ 3689 3691 W4211009551.pdf 3 31 table 0.9366117 "1st cDNA synthesis (High-capacity cDNA RT kit) 500 ng total RNA input 1st qRT-PCR for 18S & 16S rRNA → 18s/16S rR NA ra/g415o calcula/g415on 2nd cDNA synthesis (High-capacity cDNA RT kit) 4 ng hum an RNA input 2nd qRT-PCR for 18S & 16S rRNA → adjustment confirma/g415onPoly(A)+-selected cDNA synthesis (Supe rScript III First-Strand Synt hesis System ) 4 ng huma n RNA input 14X Pre-amplifica/g415on (TaqMan® PreAmp Master Mix) 10 pooled assays 3rd qRT-PCR for 10 hous e-keeping genes" 3691 4219 W4211009551.pdf 3 32 separator 0.9890711 ¶ 4219 4221 W4211009551.pdf 3 33 caption 0.99539995 "Figure 2. The flow chart displays the different steps (rows) in gene expression analysis including our modified workflow, the tasks, the required kits and the detour for adjustment of human RNA input as well as its confirmation (boxes in darker grey). The boxes in brighter grey depict the advanced methodological workflow for gene expression analysis in whole saliva samples." 4221 4608 W4211009551.pdf 3 0 separator 0.9910366 ¶ 1 2 W3109719169.pdf 14 1 text 0.99946904 "Do ponto de vista do autor (professor) uma maneira de se colocar de forma polêmica é construir seu texto, seu discurso, de maneira a expor-se a efeitos de sentidos possíveis, é deixar um espaço para a existência do ouvinte como “sujeito”." 2 245 W3109719169.pdf 14 2 separator 0.65645057 ¶ 245 247 W3109719169.pdf 14 3 text 0.9994224 "Isto é, deixar vago um espaço para o outro (o ouvinte) dentro do discurso e construir a própria possibilidade de ele mesmo (locutor) se colocar como ouvinte. É saber ser ouvinte do próprio texto e do outro." 247 458 W3109719169.pdf 14 4 separator 0.9707138 ¶ 458 460 W3109719169.pdf 14 5 text 0.9993402 "Da parte do aluno, uma maneira de instaurar o polêmico é o exercer sua capacidade de discordância, isto é, não aceitar aquilo que o texto propõe e o garante em seu valor social: é a capacidade do aluno de se constituir ouvinte e se construir como autor na dinâmica da interlocução, recusando tanto a fixidez do dito como a fixação do seu lugar como ouvinte. Ou seja, é próprio do discurso autoritário fixar o ouvinte na posição de ouvinte e o locutor na posição de locutor. Negar isso não é negar a possibilidade de ser ouvinte, é não aceitar a estagnação nesse papel, nessa posição. (ORLANDI, 1996, p. 32-33)" 460 1084 W3109719169.pdf 14 6 separator 0.9938541 ¶ 1086 1088 W3109719169.pdf 14 7 text 0.9994948 "Portanto, ante a fixidez do dito no discurso pedagógico, a autora sugere a exposição a efeitos de sentidos possíveis e o exercício da capacidade de discordância por parte do aluno." 1088 1271 W3109719169.pdf 14 8 separator 0.94547844 ¶ 1271 1273 W3109719169.pdf 14 9 text 0.99963254 "Diante da fixação dos lugares do locutor e do ouvinte, propõe-se uma dinâmica na interlocução. Segundo Orlandi, essa dinâmica de papéis promoveria uma recuperação do objeto de reflexão e uma produção de conhecimento mais conflituosa." 1273 1524 W3109719169.pdf 14 10 separator 0.96342075 ¶ 1528 1530 W3109719169.pdf 14 11 text 0.9995842 "A proposta encaminhada por Orlandi (1996) pode ser relevante para a formação de professores de PLAc uma vez que se leva em conta a existência do discurso da falta (DINIZ; NEVES, 2018) e do discurso da obrigatoriedade da aprendizagem do português (LOPEZ, 2018). A dinâmica de papéis proposta por Orlandi pode exercer deslocamentos significativos em ambos os discursos. Na medida em que a relação se faz mais conflituosa, com a possibilidade de reversibilidade de lugares, reflexão e discordância por parte do aluno, este pode se significar / ser significado por aquilo que é, que faz, que sabe e que conhece, por contraponto à sua significação, no âmbito do discurso da falta, a partir do que “não é”, “não faz”, “não sabe” e “não conhece” (cf. DINIZ; NEVES, 2018). Da mesma forma, o conflito, a dinâmica de lugares, a reflexão e a discordância em relação ao mestre pode viabilizar, no âmbito da aprendizagem do PLAc, uma relação que seja menos opressora e segregadora (cf. LOPEZ, 2018) e na qual não se desconsidera o sujeito e a(s) língua(s) que o constituem, relação na qual a língua portuguesa desponta não como uma obrigação ou uma imposição," 1530 2716 W3109719169.pdf 14 12 separator 0.96551895 ¶ 2716 2718 W3109719169.pdf 14 13 paratext 0.9824633 Gláuks: Revista de Letras e Artes– jan/jun. 2020 – Vol. 20, No 1 2718 2783 W3109719169.pdf 14 14 separator 0.7118515 ¶ 2783 2785 W3109719169.pdf 14 15 paratext 0.9840169 145 2785 2789 W3109719169.pdf 14 0 paratext 0.96536124 (Continued from previous page) 0 30 W4236330086.pdf 1 1 separator 0.9955476 ¶ 30 32 W4236330086.pdf 1 2 text 0.9737504 "Discussion: This research is of great significance for the treatment of cancer and improving the quality of life of cancer patients. The study may provide the most direct evidence for meeting clinical needs and lay a solid scientific foundation for later product development." 32 312 W4236330086.pdf 1 3 separator 0.98114514 ¶ 312 314 W4236330086.pdf 1 4 text 0.8174238 Trial registration: Chinese Clinical Trial Registry, ID: ChiCTR1800020107 . Registered on 14 December 2018. 314 422 W4236330086.pdf 1 5 separator 0.9896631 ¶ 422 424 W4236330086.pdf 1 6 paratext 0.3894316 Keywords: 424 435 W4236330086.pdf 1 7 title 0.43205312 Medicinal and edible compound prescription, YH0618 granule, Chemotherapy-induced hair 435 520 W4236330086.pdf 1 8 paratext 0.4360498 "loss, Tax" 520 532 W4236330086.pdf 1 9 title 0.39277706 anes, Anthracyclines, Kidney deficiency 532 571 W4236330086.pdf 1 10 paratext 0.3802914 and 571 575 W4236330086.pdf 1 11 title 0.40250736 renal dysfunction, Quality of life 575 610 W4236330086.pdf 1 12 separator 0.9957701 ¶ 610 612 W4236330086.pdf 1 13 title 0.8787882 Background 612 623 W4236330086.pdf 1 14 separator 0.9915122 ¶ 623 625 W4236330086.pdf 1 15 text 0.9996552 "Chemotherapy is a major type of cancer treatment using chemical medications to affect cancer cell growth, div- ision and reproduction. Regardless of the route of ad- ministration, chemotherapy drugs are introduced into the blood stream, so that chemotherapy can cause vari- ous degree of damage to other normal organs and tis- sues while killing cancer cells, further causing a series of serious adverse effects/toxicity." 625 1061 W4236330086.pdf 1 16 separator 0.88668954 ¶ 1061 1063 W4236330086.pdf 1 17 text 0.9954443 "Hair loss is an obvious side effect of chemotherapy. The incidence of chemotherapy-induced hair loss is as high as 65% in patients receiving chemotherapy and in some is even up to 80 –100% in patients receiving spe- cific agents, such as doxorubicin and docetaxel [ 1–3]. Although hair loss itself does not cause damage to the body and threaten life, it can induce persistent negative emotions such as anxiety, depression and negative evalu- ation of self-image, which in turn reduces quality of life [4]. The hair loss caused by chemotherapy is usually re- versible; however, in most cases, the color of the new hair is grayish or different from the previous color, and the hair texture also shows some changes, such as being rougher, slower growing and sparser [ 5,6]. Besides, con- temporary social media and excessive attention to ap- pearance have put more pressure on patients, with 8% of patients saying that they refuse chemotherapy because of fear of alopecia [ 7]. Even some female patients said that having no hair is more difficult to tolerate than mastec- tomy [ 8]." 1063 2181 W4236330086.pdf 1 18 separator 0.97551227 ¶ 2181 2183 W4236330086.pdf 1 19 text 0.9997222 "The mechanism of chemotherapy-induced hair loss is still unclear because of the difference between animal models and the actual human body, and the human scalp cannot be extracted for research. The current re- ported mechanisms of chemotherapy-induced hair loss mainly involve deoxyribonucleic acid (DNA) damage, hair-follicle cell-cycle inhibition, hair-follicle-cell apop- tosis, and reactive oxygen species and signal transduc- tion, etc. Accordingly, animal-model studies have found that vasoconstrictors, antioxidants, hair-growth cycle regulators and parathyroid hormone can improve hair loss caused by chemotherapy [ 9]. In clinical practice, it has been reported that minoxidil, AS101 and vitamin D3 can treat chemotherapy-induced hair loss, but the effectis not significant [ 10]. Currently, scalp-cooling is the only method approved by the US Food and Drug Ad- ministration (FDA) for use for chemotherapy-induced hair loss, and the hypothesis about its mechanism is that the low-temperature-induced rapid contraction of blood vessels can reduce blood flow into hair follicles, and cause a general reduction in cutaneous-cell metabolism, which makes the hair less affected by the chemotherapy [11]. Unfortunately, the success rate of scalp-cooling is also only 50%, and patients with cold allergy, cold agglu- tination, and cold globulinemia are not suitable for this method [ 9]. Although some progress has been made in the mechanism, research and management of alopecia, there is no very effective way in solving the hair loss caused by chemotherapy so far. Therefore, it is necessary for clinicians and researchers to pay more attention to chemotherapy-induced alopecia and a series of relevant psychological problems to further elucidate the mechan- ism of hair loss and develop safe and effective solutions." 2183 4067 W4236330086.pdf 1 20 separator 0.9813719 ¶ 4067 4069 W4236330086.pdf 1 21 text 0.99968493 "YH0618, a medicinal and edible compound prescrip- tion, is developed based on the “homology of medicine and food, ”theory ancient prescription, and long clinical practice. Our previous animal studies have shown that YH0618 decoction did not interfere with the anti-tumor effects of chemotherapy drugs [ 12]. Additionally, a ran- domized clinical trial also showed that YH0618 signifi- cantly accelerated hair regrowth and reduced thumbnail pigmentation in cancer patients who have completed chemotherapy (data was not showed, but the protocol was published in [ 13]). Therefore, this study will further explore the efficacy of YH0618 granule on chemotherapy-induced hair loss in patients with breast cancer by a randomized, double-blind, multi-center clin- ical trial. YH0618 consists of five medicinal and edible foods (black soybean and liquorice, etc.) which are rec- ommended by clinicians for cancer patients and all com- ponents have a history of safe use in other foods." 4069 5081 W4236330086.pdf 1 22 separator 0.92819864 ¶ 5081 5083 W4236330086.pdf 1 23 text 0.9994056 "Besides, each of the components possesses a distinct pharmacological profile, including removing free radicals in the body, regulating the immune system, preventing cancer, detoxifying and enhancing the sense of taste [14–16]. Black soybean and liquorice, as the main essen- tial ingredients, have been used for detoxification for" 5083 5424 W4236330086.pdf 1 24 paratext 0.96718746 You et al. Trials (2019) 20:719 Page 2 of 8 5424 5476 W4236330086.pdf 1 0 paratext 0.92139316 "REJ – Revista de Estudios de la Justicia – No 17 – Año 2012 ¶ 89" 0 104 W4251333988.pdf 6 1 separator 0.9861331 ¶ 105 107 W4251333988.pdf 6 2 title 0.7851028 adecuadamente la naturaleza del derecho. 108 149 W4251333988.pdf 6 3 text 0.9951534 "20 Quisiera detenerme en este segundo punto. Una explicación adecuada de la naturaleza de l derecho es tributaria de su capacidad para formular proposiciones necesariamente verdaderas, pero ello constituye una condición necesaria y no suficiente para el éxito de la empresa explicativa. Es efectivo que solo proposiciones nec esariamente verdaderas sobre el derecho son aptas para dar cuenta de su naturaleza, pues afirmaciones contingentemente verdaderas solo alcanzan caracterís ticas contextualizadas, que no resultan esenciales para la verificación de esta in stitución social. Pero el problema de explicar las propiedades esenciales del derecho no se traduce en identificar ciertas propiedades y no otras, sino que la identidad de u na teoría del derecho como parte de la filosofía analítica, bajo estos términos , se define porque considera que el derecho posee propiedades esenciales y, por consigu iente, reconoce su tarea en la identificación y explicación de dichas característi cas. 21" 149 1186 W4251333988.pdf 6 4 separator 0.8579157 ¶ ¶ 1188 1194 W4251333988.pdf 6 5 text 0.9949441 "Una teoría del derecho de este carácter se encuentr a comprometida en formular proposiciones necesariamente verdaderas sobr e lo que algo debe poseer para ser considerado derecho y, además, en que sus e xplicaciones sean adecuadas. 22" 1194 1435 W4251333988.pdf 6 6 separator 0.9906367 ¶ 1437 1439 W4251333988.pdf 6 7 text 0.99935347 "Este último estándar se encuentra asociado a la inco rporación del punto de vista interno de las reglas en su contenido explicativo. Una explicación sobre la naturaleza del derecho será adecuada en la medida e n que se ajuste a la comprensión de la forma en que las reglas se present an para los individuos, quienes las aceptan como criterios de conducta. El a nálisis hermenéutico esgrimido por Hart a la teoría del derecho, según el cual el derecho es entendido como una práctica social, exige analizar las accione s y prácticas de acuerdo al significado que ambas nociones representan para los partícipes de la práctica. Es decir, una teoría jurídica exitosa está sujeta a ex igencias de articular explicaciones que sean sensibles a la perspectiva que tienen los individuos que se encuentran bajo el ámbito de aplicación del fenómeno jurídico." 1439 2317 W4251333988.pdf 6 8 separator 0.90351754 "23 ¶ ¶" 2317 2380 W4251333988.pdf 6 9 bibliography 0.98236066 "20 Julie DICKSON: Evaluación en la Teoría del Derecho : 21. Para una caracterización de la teoría jurídica en torno a la coexistencia de (i) instituc iones normativas coercitivas y (ii) una síntesis de otros discursos sobre el derecho desarrollados medi ante métodos socioyhistóricos de estudio." 2380 2684 W4251333988.pdf 6 10 separator 0.7580954 ¶ 2685 2687 W4251333988.pdf 6 11 bibliography 0.99742955 "Véase, Hanoch DAGAN y Roy KREITNER: “The Character of Legal Theory”, Cornell Law Review , 96, 2011, pp. 680y687. Una perspectiva escéptica so bre la justificación y los propósitos de la filosofía del derecho en Danny PRIEL: “The Boundari es of Law and the Purpose of Legal Philosophy”, Law and Philosophy , 27, 2008, pp. 643y695." 2687 3026 W4251333988.pdf 6 12 separator 0.98228586 ¶ 3028 3030 W4251333988.pdf 6 13 bibliography 0.9972006 21 Julie DICKSON: Evaluación en la Teoría del Derecho, p. 27. 3030 3094 W4251333988.pdf 6 14 separator 0.980459 ¶ 3095 3097 W4251333988.pdf 6 15 bibliography 0.98324203 "22 Según Pablo E. Navarro y María Cristina Redondo, e l progreso en la filosofía del derecho se encuentra asociado a distintos enfoques correlativo s a la (i) obtención de explicaciones verdaderas y adecuadas a un cierto auditorio; (ii) reconstrucció n de criterios de corrección para el uso de conceptos; o (iii) reformulación de problemas filos óficos tradicionales, conectando e integrando argumentos. Pablo NAVARRO y María Cristina REDONDO: “Filosofía del derecho: problemas y posibilidades”, en del mismo, comps., La relevancia del derecho : Ensayos de filosofía jurídica, moral y política, Gedisa, Barcelona, 2002, pp. 17y31." 3097 3750 W4251333988.pdf 6 16 separator 0.96586496 ¶ 3751 3753 W4251333988.pdf 6 17 bibliography 0.9970392 23 Julie DICKSON: Evaluación en la Teoría del Derecho , p. 32. 3753 3817 W4251333988.pdf 6 0 paratext 0.9552488 "www.nature.com/scientificreports/12 Scientific RepoRts | 5:18413 | DOI: 10.1038/srep1841329." 0 96 W2399366904.pdf 11 1 bibliography 0.997893 "Abualrous, E. T. et al. F pocket flexibility influences the tapasin dependence of two differentially disease-associated MHC Class I proteins. Eur J Immunol 45, 1248–1257 (2015)." 96 278 W2399366904.pdf 11 2 separator 0.9455332 ¶ 278 280 W2399366904.pdf 11 3 bibliography 0.9978453 "30. Powis, S. J., Santos, S. G. & Antoniou, A. N. Biochemical features of HLA-B27 and antigen processing. Adv Exp Med Biol 649, 210–216 (2009)." 280 427 W2399366904.pdf 11 4 separator 0.9250301 ¶ 427 429 W2399366904.pdf 11 5 bibliography 0.9947162 "31. Posteraro, B. et al. The link between genetic variation and variability in vaccine responses: systematic review and meta-analyses. Vaccine 32, 1661–1669 (2014)." 429 598 W2399366904.pdf 11 6 separator 0.87466776 ¶ 598 600 W2399366904.pdf 11 7 bibliography 0.99808353 "32. Ovsyannikova, I. G., Pankratz, V . S., Larrabee, B. R., Jacobson, R. M. & Poland, G. A. HLA genotypes and rubella vaccine immune response: additional evidence. Vaccine 32, 4206–4213 (2014)." 600 798 W2399366904.pdf 11 8 separator 0.883937 ¶ 798 800 W2399366904.pdf 11 9 bibliography 0.99783754 "33. Loffredo, J. T. et al. Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity. J Immunol 182, 7763–7775 (2009)." 800 1026 W2399366904.pdf 11 10 separator 0.9336784 ¶ 1026 1028 W2399366904.pdf 11 11 bibliography 0.997305 "34. Kaslow, R. A. et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 2, 405–411 (1996)." 1028 1192 W2399366904.pdf 11 12 separator 0.92073333 ¶ 1192 1194 W2399366904.pdf 11 13 bibliography 0.99807864 35. Adelson, J. D. et al. Developmental Sculpting of Intracortical Circuits by MHC Class I H2-Db and H2-Kb. Cereb Cortex, 1–11 (2014). 1194 1329 W2399366904.pdf 11 14 separator 0.78896475 ¶ 1329 1331 W2399366904.pdf 11 15 bibliography 0.99803793 36. Lee, H. et al. Synapse elimination and learning rules co-regulated by MHC class I H2-Db. Nature 509, 195–200 (2014). 1331 1453 W2399366904.pdf 11 16 separator 0.85337865 ¶ 1453 1455 W2399366904.pdf 11 17 bibliography 0.99794775 37. Bergeron, B. Bioinformatics Computing 1st edn (Prentice Hall, 2002). 1455 1529 W2399366904.pdf 11 18 separator 0.7836098 ¶ 1529 1531 W2399366904.pdf 11 19 bibliography 0.99808323 "38. Bagaria, A., Jaravine, V ., Huang, Y . J., Montelione, G. T. & Guntert, P . Protein structure validation by generalized linear model root- mean-square deviation prediction. Protein Sci 21, 229–238 (2011)." 1531 1742 W2399366904.pdf 11 20 separator 0.8374109 ¶ 1742 1744 W2399366904.pdf 11 21 bibliography 0.9980251 "39. Madurga, S., Belda, I., Llora, X. & Giralt, E. Design of enhanced agonists through the use of a new virtual screening method: application to peptides that bind class I major histocompatibility complex (MHC) molecules. 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We would like to thank the Centro de Supercomputação da UFRGS (CESUP-UFRGS) for providing its facilities and support. The authors would also like to thank Caio Diniz de Farias, Marina Roberta Scheid, Renata Fioravanti Tarabini and Marcelo Alves Bragatte de Souza for their involvement in this project, as well as Dr. José Artur Bogo Chies, for the support and immunological discussions. Finally, we thank Dr. Didier Devaurs for his helpful comments on the final manuscript." 5763 6499 W2399366904.pdf 11 68 separator 0.99622107 ¶ 6499 6501 W2399366904.pdf 11 69 title 0.9783141 Author Contributions 6501 6522 W2399366904.pdf 11 70 separator 0.9961236 ¶ 6522 6524 W2399366904.pdf 11 71 text 0.9968856 "M.M.R., D.A.A., M.S. and G.F.V . conceived the study. M.M.R. wrote the paper. M.M.R. and D.A.A. developed the scripts for the DockTope automation. M.M.R., D.A.A., M.F.A.M., M.V .F. conducted experiments. M.M.R., D.A.A., M.F.A.M., M.V .F., L.M., M.S. and G.F.V . analysed and interpreted the data. M.F. and L.M. were responsible for web-server development and the database integration with CESUP-UFRGS. M.M.R., D.A.A., M.F.A.M., M.V .F., M.S., L.M. and G.F.V . revised the manuscript for intellectual content and approved the final version to be published." 6524 7092 W2399366904.pdf 11 72 separator 0.9956088 ¶ 7092 7094 W2399366904.pdf 11 73 title 0.9746396 Additional Information 7094 7117 W2399366904.pdf 11 74 separator 0.9944155 ¶ 7117 7119 W2399366904.pdf 11 75 text 0.95578796 Supplementary information accompanies this paper at http://www.nature.com/srep 7119 7198 W2399366904.pdf 11 0 paratext 0.97869134 JANSSEN & JANSEN  PERSUASION BY NUMBERS | 82 0 45 W2805772826.pdf 21 1 separator 0.9902007 ¶ 46 48 W2805772826.pdf 21 2 bibliography 0.997955 "Marshall, R., Chuan, N.E., and WoonBong, N. ( 2002). Children’s use of consumer heuristics. In: S.M. Broniarczyk and K. Nakamoto (Eds.), Advances in consumer research (Vol 28). 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Reflexão , v. 47, e226523, 2022. https://doi.org/10.24220/2447-" 3090 3324 W4313304526.pdf 14 45 paratext 0.8915112 ¶ 6803v47e2022a6523 3324 3344 W4313304526.pdf 14 46 separator 0.9807191 ¶ 3344 3346 W4313304526.pdf 14 47 paratext 0.9546908 Recebido em 3/8/2022 e aprovado em 7/11/2022. 3346 3392 W4313304526.pdf 14 0 bibliography 0.57640034 Prandner, D. 0 12 W2883544403.pdf 6 1 paratext 0.48907053 ; 12 13 W2883544403.pdf 6 2 bibliography 0.53770137 Moosbrugger, 13 26 W2883544403.pdf 6 3 paratext 0.5774418 R. 26 29 W2883544403.pdf 6 4 separator 0.9861541 ¶ ¶ 31 38 W2883544403.pdf 6 5 text 0.9993165 "influences the intention of working in the field of journalism. The better the con ditions when growing up are rat ed the more likely the individuals are to intend to work in journalism. The motives are most strongly tied to the sociodemographic control variables (sex and age). Men are more interested to work on the political and social agenda setting ." 40 408 W2883544403.pdf 6 6 separator 0.5736624 ¶ 409 411 W2883544403.pdf 6 7 text 0.99942696 "The older the respondents are the less interested they ar e to work on those issues and the less important the social benefits going along with the profession are. The intention to work in the field of journalism is dependent on the motives agency , employment and calling ." 411 694 W2883544403.pdf 6 8 separator 0.9605144 ¶ 695 697 W2883544403.pdf 6 9 text 0.99967283 "Someone reporting the motive of agency is more likely to intend to work in the field. The same is true for those who think journalism is their calling . Those focusing on employment related issues rather do not intend to work as journalists. Those seem to be individuals interested in the field but well aware of the struggles in the job market. Yet the context of where someone studies and how far he or she has progressed in his or her studies does not make any difference on their aspiration to work as journalists." 697 1234 W2883544403.pdf 6 10 separator 0.9919903 ¶ ¶ 1236 1242 W2883544403.pdf 6 11 title 0.98700315 4. Conclusion 1242 1256 W2883544403.pdf 6 12 separator 0.9968091 ¶ 1258 1260 W2883544403.pdf 6 13 text 0.99974966 "Our results show that the motivation to join the j ournalistic profession is deepl y related to beliefs of individuals. Those who study journalism related subjects at the tertiary educational level have n ormative aspirations lik e a political or social agenda and interpret journalism as a calling . Understand ably so as those ideas are deeply ingrain ed into the doxa as well as the illusio of the field (Kirchhoff & Prandner, 2016). Journalism is framed as a profession that strives to challenge the mighty , where those who think the y have the talent to be a wordsmith aim to make their mark, as the term the fourth estate so vivi dly illustra tes (McQuail , 2013) a nd makes interested individuals endure in a dire job market (Dora et al. , 2009). Yet those fundamental underpinnings are not the primary concern for many who study journalism. T hose who are focusing on employability are less likely to aspire to be journalist s, even if they study a subject with close t ies to the field. For educators this heteroginity in higher education has to be seen as challenge, as the field of journalism studies is highly normative and tied to the concept of the fourth estate and civil sphere. The discrepancy between curricular focus and students aspirations makes it necessary to rethink how core co ncepts of journalism related education can be framed in a broader context. That the education of the parents is a deciding influence on the reasons why someone aspires a profession and how someone choses which university he or she visits matches with former empirical findings . In Austria education is still strongly tied to family background and people from families with lower education are more likely to search for education that brings more tangible results and increases their employability. Even as more employment driven training and education programs are offered, journalism remains a field that is governed by the aspirations and believes of individuals and the illusio individuals bring with themselves." 1260 3357 W2883544403.pdf 6 14 separator 0.9900719 ¶ 3359 3361 W2883544403.pdf 6 15 paratext 0.9464877 635 3361 3365 W2883544403.pdf 6 0 bibliography 0.99746716 "22. T. P. Hughes, M. L. Barnes, D. R. Bellwood, J. E. Cinner, G. S. Cumming, J. B. C. Jackson, J. Kleypas, I. A. van de Leemput, J. M. Lough, T. H. Morrison, S. R. Palumb i, E. H. van Nes, M. 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Sci . 944 012030: 1 – 12 (2021)" 1368 1533 W4396628950.pdf 12 15 separator 0.96917784 ¶ 1535 1537 W4396628950.pdf 12 16 bibliography 0.99786884 "30. S. Campbell, E. S. Darling, S. Pardede, G. N. Ahmadia, S. Mangubhai, Amkieltiela, Estradivari, E. Maire, Conservation Letters, 13(2) , e12698, 1-9 (2020)" 1537 1699 W4396628950.pdf 12 17 separator 0.9633788 ¶ 1701 1703 W4396628950.pdf 12 18 bibliography 0.997981 31. K. Wibowo, M. Adrim, P. C. Makatipu, Mar. Res. Indonesia 38(1), 1−8 (2013) 1703 1784 W4396628950.pdf 12 19 separator 0.951067 ¶ 1786 1788 W4396628950.pdf 12 20 bibliography 0.99760383 "32. M. Ulfah, S.N. Fajri, M. Nasir, K Hamsah, S. Purnawan , IOP Conf. Ser.: Earth Environ. Sci. 348 012074 : 1 - 6 (2019)" 1788 1913 W4396628950.pdf 12 21 separator 0.89655447 "¶ ¶ ¶" 1915 1933 W4396628950.pdf 12 22 paratext 0.8872544 13BIO Web of Conferences 106, 02014 (2024) 1933 1976 W4396628950.pdf 12 23 separator 0.70803356 ¶ 1976 1978 W4396628950.pdf 12 24 paratext 0.9742905 ICMS 2023 https://doi.org/10.1051/bioconf/202410602014 1978 2033 W4396628950.pdf 12 0 paratext 0.98554504 Page 2 of 9 Matei et al. Parasites Vectors (2021) 14:107 0 65 W3127080848.pdf 1 1 separator 0.9917854 ¶ 66 68 W3127080848.pdf 1 2 title 0.8814313 Background 68 79 W3127080848.pdf 1 3 separator 0.9922263 ¶ 79 81 W3127080848.pdf 1 4 text 0.99942476 "Among tick-borne diseases, rickettsioses are considered to be the oldest known affecting humanity. Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group (SFG) of the genus Rickettsia, one of the most diverse groups among Rick - ettsiales, comprising a large number of zoonotic agents [1]. The first clinical description of the prototypical tick-borne rickettsiosis (Rocky Mountain spotted fever, RMSF) was made in 1899 by Edward E. Maxey [2]. Its agent, Rickettsia rickettsii, was demonstrated to have vectorial transmission in 1906 by Howard T. Ricketts [3], which was later confirmed by S. Burt Wolbach [4]." 81 777 W3127080848.pdf 1 5 separator 0.8907882 ¶ 777 779 W3127080848.pdf 1 6 text 0.99958456 "This complex of diseases is still intensively studied, and newly associated clinical conditions are continu - ously described. Its importance and recognition have increased considerably over the last 3 decades [1]. More than 24 Rickettsia species and subspecies are associ - ated with human infections, while for many others the public health relevance is still unknown [1]. In Europe, eight tick-borne rickettsiae with known pathogenic - ity to humans were reported in European patients: R. aeschlimannii , R. conorii subsp. conorii, R. helvet - ica, R. massiliae, R. monacensis, R. raoultii, R. sibirica subsp. mongolitimonae, and R. slovaca. Additionally, 15 Candidatus Rickettsia species and strains of unknown pathogenicity were also described [1]. Seven of the eight human pathogenic species were previously reported in Romania (Table 1) [5–15]. Despite the common detec - tion of tick-borne rickettsiae in ticks collected from diverse hosts, to the best of our knowledge, they have been reported only in humans and birds in Romania." 779 1866 W3127080848.pdf 1 7 separator 0.98441935 ¶ 1866 1868 W3127080848.pdf 1 8 text 0.9864714 "Romania has a remarkable biodiversity, having in its territory 21 ecoregions in 5 biogeographical regions [16]. " 1868 1985 W3127080848.pdf 1 9 separator 0.6150438 ¶ 1985 1986 W3127080848.pdf 1 10 text 0.99966437 "This unique situation is associated with a wide range of habitats and is mirrored by a very rich fauna including 32 species of insectivorous bats [17], more than 82% of all continental European bat species [18]. Romania is not only diverse in species, but also hosts large bat popula - tions, including two of the largest hibernating colonies of bats from Europe (> 100,000 individuals) [19]." 1986 2396 W3127080848.pdf 1 11 separator 0.9503685 ¶ 2396 2398 W3127080848.pdf 1 12 text 0.99959564 "Bats are well-known reservoir hosts for important zoonotic viruses such as Lyssavirus and Ebola virus, probable reservoirs for Hendra and Nipah henipaviruses, MERS and SARS coronaviruses, probably including SARS-CoV-2, and other emerging viruses [20, 21]. Along - side viruses, in the last few years, bacterial and protozoan pathogens from bats have been intensively studied to clarify their zoonotic potential. As a result, several path - ogens have been identified in different samples (blood, Results: Positive results were obtained in 14.6% of bat samples. Sequence analysis confirmed the presence of R. monacensis in two bat species (Nyctalus noctula and Pipistrellus pipistrellus) in two locations." 2398 3130 W3127080848.pdf 1 13 separator 0.9597007 ¶ 3130 3132 W3127080848.pdf 1 14 text 0.9992015 "Conclusion: This study provides the first evidence of a possible involvement of these bat species in the epidemiol- ogy of Rickettsia spp., highlighting the importance of bats in natural cycles of these vector-borne pathogens." 3132 3361 W3127080848.pdf 1 15 separator 0.99574304 ¶ 3361 3363 W3127080848.pdf 1 16 paratext 0.43681479 Keywords: Chir 3363 3378 W3127080848.pdf 1 17 text 0.37593678 optera, 3378 3385 W3127080848.pdf 1 18 paratext 0.3241317 In 3385 3388 W3127080848.pdf 1 19 text 0.30680832 s 3388 3389 W3127080848.pdf 1 20 title 0.31397402 ectivorous 3389 3399 W3127080848.pdf 1 21 text 0.36945048 bats, S 3399 3407 W3127080848.pdf 1 22 paratext 0.32933378 FG 3407 3410 W3127080848.pdf 1 23 text 0.32499525 rickettsiae, Vector-borne diseases, 3410 3445 W3127080848.pdf 1 24 paratext 0.31186312 Zoo 3445 3449 W3127080848.pdf 1 25 text 0.30152708 no 3449 3451 W3127080848.pdf 1 26 title 0.3011327 tic reservoir 3451 3464 W3127080848.pdf 1 0 title 0.57749236 Prophylaxis against MDR TB 0 26 W2128235672.pdf 3 1 separator 0.99252963 ¶ 26 28 W2128235672.pdf 3 2 bibliography 0.9963552 "8. Markowitz N, Hansen NI, Hopewell PC, Glassroth J, Kvale PA, Mangura BT, et al. Incidence of tuberculosis in the United States among HIV-infected persons. The Pulmonary Com - plications of HIV Infection Study Group. Ann Intern Med. 1997;126:123–32. http://dx.doi.org/10.7326/0003-4819-126-2- 199701150-00005" 30 353 W2128235672.pdf 3 3 separator 0.97745 ¶ 353 355 W2128235672.pdf 3 4 bibliography 0.9974163 "9. Schluger NW, Burzynski J. Tuberculosis and HIV infection: epide - miology, immunology, and treatment. HIV Clin Trials. 2001;2:356– 65. http://dx.doi.org/10.1310/TUNH-UAKU-N0E4-1PXF" 357 545 W2128235672.pdf 3 5 separator 0.98499054 ¶ 545 547 W2128235672.pdf 3 6 bibliography 0.9977568 "10. Younossian AB, Rochat T, Ketterer JP, Wacker J, Janssens JP. High hepatotoxicity of pyrazinamide and ethambutol for treatment of latent tuberculosis. Eur Respir J. 2005;26:462–4. http://dx.doi.or g/ 10.1183/09031936.05.00006205" 547 788 W2128235672.pdf 3 7 separator 0.98170483 ¶ 788 790 W2128235672.pdf 3 8 bibliography 0.99784815 "11. Ridzon R, Meador J, Maxwell R, Higgins K, Weismuller P, Onorato IM. Asymptomatic hepatitis in persons who received alterna - tive preventive therapy with pyrazinamide and ofloxacin. Clin Infect Dis. 1997;24:1264–5. http://dx.doi.org/10.1093/clinids/24.6.1264" 790 1062 W2128235672.pdf 3 9 separator 0.9798193 ¶ 1062 1064 W2128235672.pdf 3 10 bibliography 0.99794567 "12. Horn DL, Hewlett D Jr, Alfalla C, Peterson S, Opal SM. Limited tolerance of ofloxacin and pyrazinamide prophylaxis against tuberculosis. N Engl J Med. 1994;330:1241. http://dx.doi. org/10.1056/NEJM199404283301718" 1064 1287 W2128235672.pdf 3 11 separator 0.97943795 ¶ 1287 1289 W2128235672.pdf 3 12 bibliography 0.9979711 "13. Papastavros T, Dolovich LR, Holbrook A, Whitehead L, Loeb M. Ad - verse events associated with pyrazinamide and levofloxacin in the treat - ment of latent multidrug-resistant tuberculosis. CMAJ. 2002;167:131–6." 1289 1508 W2128235672.pdf 3 13 separator 0.97749925 ¶ 1508 1510 W2128235672.pdf 3 14 bibliography 0.99574345 "14. Adler-Shohet FC, Low J, Carson M, Girma H, Singh J. Manage - ment of latent tuberculosis infection in child contacts of multidrug- resistant tuberculosis. Pediatr Infect Dis J. 2014;33:664–6. http://dx.doi.org/10.1097/INF.0000000000000260" 1510 1761 W2128235672.pdf 3 15 separator 0.9843232 ¶ 1761 1763 W2128235672.pdf 3 16 bibliography 0.99791616 "15. Bamrah S, Dorina F, Setik L, Song R, Kawamura LM, A. Heetderks A, et al. Treatment for LTBI in contacts of MDR-TB patients, Federated States of Micronesia, 2009–2012. Int J Tuberc Lung Dis. 2014;18:912–8." 1763 1982 W2128235672.pdf 3 17 separator 0.9911511 ¶ 1982 1984 W2128235672.pdf 3 18 contact 0.99236447 "Address for correspondence: Lisa Trieu, NYC Department of Health and Mental Hygiene, Bureau of Tuberculosis Control, 42-09 28th Street, 21st Fl, CN-72B, WS21-10, Long Island City, NY 11101, USA; email: ltrieu@health.nyc.gov" 1984 2217 W2128235672.pdf 3 19 separator 0.96483815 ¶ 2217 2219 W2128235672.pdf 3 20 paratext 0.94615495 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 21, No. 3, March 2015 503November 2014: 2220 2314 W2128235672.pdf 3 21 separator 0.9404351 ¶ 2316 2318 W2128235672.pdf 3 22 title 0.9771439 Foodborne Infections 2318 2339 W2128235672.pdf 3 23 separator 0.8674533 ¶ 2339 2341 W2128235672.pdf 3 24 title 0.66800386 Including : 2341 2353 W2128235672.pdf 3 25 separator 0.4621153 ¶ 2353 2355 W2128235672.pdf 3 26 table 0.4069611 • 2355 2357 W2128235672.pdf 3 27 title 0.46368203 Blastomycosis Mortality Rates, 2358 2389 W2128235672.pdf 3 28 table 0.60667694 ¶ 2391 2393 W2128235672.pdf 3 29 title 0.4106363 United States 2393 2407 W2128235672.pdf 3 30 table 0.41823363 , 1990 2407 2413 W2128235672.pdf 3 31 title 0.37750527 – 2413 2414 W2128235672.pdf 3 32 table 0.52716 "2010 •" 2414 2422 W2128235672.pdf 3 33 title 0.6119325 Legionnaires’ Disease Incidence and 2423 2459 W2128235672.pdf 3 34 table 0.47351438 ¶ 2460 2462 W2128235672.pdf 3 35 title 0.5284247 Risk Factors, New York, New York, USA, 2462 2501 W2128235672.pdf 3 36 table 0.594314 ¶ 2002 2502 2509 W2128235672.pdf 3 37 title 0.42308143 – 2509 2510 W2128235672.pdf 3 38 table 0.44747347 2011 2510 2514 W2128235672.pdf 3 39 separator 0.619284 ¶ 2514 2516 W2128235672.pdf 3 40 table 0.46275124 • 2516 2518 W2128235672.pdf 3 41 title 0.5747643 Death Patterns during the 1918 2519 2550 W2128235672.pdf 3 42 table 0.56028116 ¶ 2552 2554 W2128235672.pdf 3 43 title 0.5344194 Influenza Pandemic in Chile 2554 2582 W2128235672.pdf 3 44 separator 0.5556075 ¶ 2582 2584 W2128235672.pdf 3 45 title 0.82567275 "• Genomic Definition of Hypervirulent and Multidrug-Resistant Klebsiella pneumoniae Clonal Groups" 2584 2692 W2128235672.pdf 3 46 separator 0.49892145 2692 2693 W2128235672.pdf 3 47 table 0.37363693 ¶ 2693 2694 W2128235672.pdf 3 48 title 0.6944029 "• Respiratory Viruses and Bacteria among Pilgrims during the 2013 Hajj" 2694 2770 W2128235672.pdf 3 49 separator 0.66978246 ¶ 2770 2772 W2128235672.pdf 3 50 title 0.80962306 "• Drug-Resistant Candida glabrata Infec - tion in Cancer Patients" 2772 2842 W2128235672.pdf 3 51 table 0.34639746 ¶ 2842 2844 W2128235672.pdf 3 52 title 0.7607452 "• Novel Chlamydia trachomatis Strains in Heterosexual Sex Partners," 2844 2920 W2128235672.pdf 3 53 separator 0.69976544 ¶ 2923 2925 W2128235672.pdf 3 54 title 0.6685879 Indianapolis, Indiana, USA 2925 2952 W2128235672.pdf 3 55 separator 0.9603564 ¶ 2952 2954 W2128235672.pdf 3 56 paratext 0.9456394 http://wwwnc.cdc.gov/eid/articles/issue/20/11/table-of-contents 2954 3018 W2128235672.pdf 3 0 paratext 0.98221004 "Educational Research in Universal Sciences ISSN: 2181 -3515 VOLUME 2 | ISSUE 5 | 2023 ¶ https://t.me/Erus_uz Multidisciplinary Scientific Journal May, 2023 673" 0 408 W4381236837.pdf 0 1 separator 0.95811135 ¶ ¶ 409 416 W4381236837.pdf 0 2 title 0.99234504 "PRESUPPOZITSIYA ATAMASIGA DOIR NAZARIY QARASHLAR TAHLILI" 416 477 W4381236837.pdf 0 3 separator 0.90835905 ¶ ¶ 479 485 W4381236837.pdf 0 4 contact 0.99313754 "Sarbarova Dilnoza Nosirjon qizi O‘zbekiston Milliy universiteti O‘zbek tilshunosligi kafedrasi o‘qituvchisi Email: dilnozasarbarova1@gmail.com" 485 640 W4381236837.pdf 0 5 separator 0.9748782 ¶ ¶ 642 648 W4381236837.pdf 0 6 title 0.9916571 ANNOTATSIYA 648 660 W4381236837.pdf 0 7 separator 0.99452144 ¶ 662 664 W4381236837.pdf 0 8 text 0.99801725 "Presuppozitsiya tushunchasi, uning kelib chiqish tarixi hamda tilshunoslikdagi o‘rni va ahamiyati mazkur maqolada yoritib berilgan. Shuningdek, lingvistik presuppozitsiya bilan bog‘liq nazariy qarashlar ham bayon qilingan." 664 894 W4381236837.pdf 0 9 separator 0.96318114 ¶ 896 898 W4381236837.pdf 0 10 text 0.93163204 "Kalit so‘zlar: presuppozitsiya, pragmatika, tag ma’no, yashirin axborot, tejamlilik, propozitsiya." 898 1000 W4381236837.pdf 0 11 separator 0.9368112 ¶ ¶ 1002 1008 W4381236837.pdf 0 12 text 0.99956304 "Keyingi davrlarda lingvistik presuppozitsiya masalasi ko‘plab tilshunos olimlarning diqqat e’tiborini tortib kelmoqda. Presuppozitsiya atamasi nemis mantiqshunosi G.Frege g‘oyalari bilan bog‘liq hisoblanadi. Fregening fikricha, asosiy hukm ko‘p hollarda boshqa yashirin hukm bilan birgalikda keladi. Uning ta’limotiga ko‘ra mavjudlikni bildiruvchi ikkinchi darajali yashirin hukmgina presuppozitsiya hisoblanadi. Ushbu atamaning qo‘llanilishi P.Strouson nomi bilan ham bog‘ liqdir. U ham huddi Frege singari presuppozitsiyani gaplar o‘rtasidagi semantik munosabatdan kelib chiqishini ta’kidlaydi." 1008 1627 W4381236837.pdf 0 13 separator 0.98836774 ¶ 1632 1634 W4381236837.pdf 0 14 text 0.99916154 "Presuppozitsiya tushunchasi tilning pragmatik aspektini namoyon etadigan hodisa bo‘lib, gapda, nutq shakllanishida shu bilan birg a shaxslarning nut jarayoni va ob’ekti to‘g‘risidagi umumiy ma’lumotlari bilan uzviy bog‘lanadi. Shuningdek, gapning semantik jihatdan tuzilishi bilan bog‘liq hodisa sifatida alohida tadqiqotlarni talab qiladi. Lingvistik presuppozitsiya ko‘p hollarda til shunosligimizda doimiy qo‘laniluvchi tejash tamoyili asosida hosil bo‘ladi. N.Mahkamov tejamlilik xususida shunday deydi: tejamlilik o‘ziga xos xususiyatlarga ega bo‘lib, unda leksik yoki grammatik ma’no bajarayotgan birlik vazifasi shu birliklar majmuasid agi boshqa birlikka yuklatiladi. Natijada vazifa bajarmayotgan birlik majmua (so‘z, birikma, gap) tarkibidan chiqariladi va nisbatan shakliy ixchamlik vujudga keladi [2]. A.Nurmonov ilmiy ishlarining birida presuppozitsiya va tag ma’no haqida so‘z yuritadi va shunday deydi: Bizning fikrimizcha presuppozitsiyani yashirin ma’no bilan bog‘lasak, presuppozitsiya va tag ma’noning o‘rtasidagi farqni yo‘qqa chiqarib qo‘yamiz. Bizning" 1634 2746 W4381236837.pdf 0 0 text 0.9958503 "veridically reported perceiving first and third objects as weighing the same; 4/10 participants were not naı ̈ve, as we had demonstrated the effect to them in the days prior to the meeting." 0 189 W4239803621.pdf 1 1 separator 0.9242356 ¶ 189 191 W4239803621.pdf 1 2 text 0.99864465 "Both naı ̈ve and nonnaı ̈ve participants experienced the illusory weight change; knowledge of the illusion did not appear to weaken the effect, suggesting it might be cognitively impenetrable (Lupyan, 2015)." 191 402 W4239803621.pdf 1 3 separator 0.98434603 ¶ 402 404 W4239803621.pdf 1 4 text 0.99944514 "Following the discussions that took place at the group meeting, we concluded that the illusion is likely related to the interaction between short-term motor adaptation andviolations of sensorimotor expectations (van Polanen & Davare, 2015). The forces thathumans use to pick up an object tend to be scaled based on previous lifts. The lightwooden object therefore likely induced participants to use less force to hold the heavyobject the second time around, which resulted in the heavy object feeling heavier. We set out to test whether this effect would survive cognition, that is, knowledge of the relationships between the weights of the objects." 404 1059 W4239803621.pdf 1 5 separator 0.9882715 ¶ 1059 1061 W4239803621.pdf 1 6 text 0.9910582 "We recruited 70 participants: 30 for Experiment 1 (19 women, 1 left-handed, mean /C6SD age: 27 /C67), 20 for Experiment 2 (9 women, 2 left-handed, mean /C6SDage: 29 /C67), and 20 for Experiment 3 (16 women, 0 left-handed, mean /C6SDage: 25 /C64). Participants were staff" 1061 1335 W4239803621.pdf 1 7 separator 0.9778253 ¶ 1335 1337 W4239803621.pdf 1 8 caption 0.99626094 "Figure 1. Very formal results from the informal experiment. Data and analyses are openly shared directly from the experimenter’s lab notebook. Rating data were normalized by subtracting each participant’s mean rating. Mean normalized weight ratings were hand-plotted as a function of object number onto theconference room black board. Error bars are 95% confidence intervals. Objects 1 and 3 are the same." 1337 1747 W4239803621.pdf 1 9 paratext 0.94857854 2 i-Perception 9(4) 1747 1766 W4239803621.pdf 1 0 paratext 0.99050045 Mar. Drugs 2017 ,15, 96 8 of 19 0 31 W2597772549.pdf 7 1 separator 0.99311465 ¶ 31 33 W2597772549.pdf 7 2 title 0.99452573 3. Chitosan Nanoparticles in Chemotherapeutic Delivery 33 88 W2597772549.pdf 7 3 separator 0.9961839 ¶ 88 90 W2597772549.pdf 7 4 text 0.99971557 "Nano-drug delivery systems using chitosan offer many advantages. These systems minimize drug clearance in the circulation, control release of drug, reduce drug cytotoxicity, and increase therapeutic index. Moreover, the biodegradability and biocompatibility have made chitosan a suitable material for chemo-drug delivery in cancer therapy. Chitosan is mucoadhesive, and its cationic nature allows for enhanced affinity towards mucous membrane, thereby assisting trans-mucosal drug delivery. These properties of chitosan would be useful in intra-nasal and intrapulmonary delivery of chemotherapeutics for cancers especially of the nasopharyngeal and lung tissues." 90 764 W2597772549.pdf 7 5 separator 0.9969952 ¶ 764 766 W2597772549.pdf 7 6 title 0.99433076 3.1. Delivery of Hydrophilic Chemotherapeutics 766 813 W2597772549.pdf 7 7 separator 0.99646413 ¶ 813 815 W2597772549.pdf 7 8 text 0.9997738 "Chitosan nanoparticles can be used to deliver both hydrophilic drugs [ 61,62], and hydrophobic drugs [ 63,64]. The presence of many free amine groups can be easily functionalized for conjugation of chemotherapeutic drugs. For example, in a recent study, water-soluble drug doxorubicin (DOX) was conjugated to chitosan using a succinic anhydride spacer [ 62]. The succinic anhydride could react with the amine of DOX and functionalize to become carboxylic. This carboxylic acid of DOX was then conjugated with chitosan’s free amine groups using carbodiimide chemistry." 815 1393 W2597772549.pdf 7 9 separator 0.9628318 ¶ 1393 1395 W2597772549.pdf 7 10 text 0.9997101 "The chitosan-DOX was then self-assembled to form nanoparticles in aqueous solution under stirring at room temperature. However, the introduction of more DOX reduced the conjugation efficiency to chitosan. The Her2+ (human epidermal growth factor receptor 2+) targeting monoclonal antibody, trastuzumab was also conjugated to chitosan-DOX nanoparticles via thiolation of lysine residues (by reacting with primary amines) and subsequent linking of the resulted thiols to chitosan." 1395 1881 W2597772549.pdf 7 11 separator 0.96618396 ¶ 1881 1883 W2597772549.pdf 7 12 text 0.99962246 "The trastuzumab conjugated chitosan-DOX nanoparticles showed target specificity towards Her2+ cancer cells, resulting in enhanced uptake compared to chitosan-DOX and free drug. Also, trastuzumab conjugated chitosan-DOX nanoparticles could efficiently discriminate between Her2+ and Her2" 1883 2172 W2597772549.pdf 7 0 paratext 0.981434 fmicb-08-01703 September 5, 2017 Time: 16:57 # 5 0 48 W2746646675.pdf 4 1 separator 0.9571858 ¶ 48 50 W2746646675.pdf 4 2 title 0.9798999 Zheng et al. Sulfasalazine Modulates Gut Microbiome 50 102 W2746646675.pdf 4 3 separator 0.9948508 ¶ 102 104 W2746646675.pdf 4 4 caption 0.99633265 "FIGURE 1 | SASP reduces inflammation in TNBS-induced colitis. Effects of SASP treatment on the disease activity index (A), MPO activity (B), the length of the colon (C), histopathological score (G). And the representative pathological section of the colon tissues from rats in the model group (D), the control group (E), and the SASP group (F). Scale bar, 200 mm. Data are expressed as mean SD. The differences in (A–C,G) were analyzed using one-way ANOVA followed by Tukey’s post hoc tests (P<0.05,P<0.01)." 104 621 W2746646675.pdf 4 5 separator 0.99452627 ¶ 621 623 W2746646675.pdf 4 6 paratext 0.97836685 Frontiers in Microbiology | www.frontiersin.org 5 September 2017 | Volume 8 | Article 1703 623 714 W2746646675.pdf 4 0 paratext 0.9593269 Enhancing Navigation in Difficult Environments with Low-Cost, Dual-Frequency GNSS PPP and MEMS IMU 145 0 101 W3037280355.pdf 2 1 separator 0.98720264 ¶ 101 103 W3037280355.pdf 2 2 table 0.9772116 "Accelerometers GyroscopesResolveGravity AttitudeInitial velocityVelocity Position Initial AttitudeInitial position" 103 236 W3037280355.pdf 2 3 separator 0.9683764 ¶ 236 238 W3037280355.pdf 2 4 caption 0.99422497 Fig. 1 Block diagram of IMU mechanization process (after Titterton et al. 2004 ) 238 319 W3037280355.pdf 2 5 separator 0.94571555 ¶ 319 321 W3037280355.pdf 2 6 caption 0.39213845 Input 321 327 W3037280355.pdf 2 7 text 0.50012153 s 327 328 W3037280355.pdf 2 8 caption 0.43009698 to 328 331 W3037280355.pdf 2 9 text 0.4542305 IMU 331 335 W3037280355.pdf 2 10 caption 0.39217874 mechanization are 335 353 W3037280355.pdf 2 11 text 0.43874282 specific force 353 367 W3037280355.pdf 2 12 caption 0.4537215 fband 367 373 W3037280355.pdf 2 13 text 0.817092 "¶ turn rates !b ib. Mechanization process including equations are described in detail in (Farrell 2008 )." 373 483 W3037280355.pdf 2 14 separator 0.99645716 ¶ 483 485 W3037280355.pdf 2 15 title 0.9438941 "3 GNSS PPP/INS Tightly Coupled Kalman Filter" 485 532 W3037280355.pdf 2 16 separator 0.990546 ¶ 532 534 W3037280355.pdf 2 17 text 0.9991402 "In this research, a tightly-coupled Extended Kalman Filter (EKF) is used to fuse the GNSS and IMU measurements. In a tightly-coupled integration architecture, raw measurements from the sensors are used, which enables continuous naviga- tion during a GNSS signal outage. The typical error budget for GNSS PPP is listed in Table 1." 534 874 W3037280355.pdf 2 18 separator 0.80514693 ¶ 874 876 W3037280355.pdf 2 19 text 0.9984143 "The inputs to the complementary Kalman filter are (1) code and phase measurements from a low-cost DF GNSS receiver corrected for atmosphere, relativistic errors and clock and orbit errors using the precise PPP corrections, and (2) predicted code and phase measurements that are formed using the IMU position and velocity with the satellite position and velocity. For this research work, the ionosphere- free (IF) model is used to avoid estimation of the iono- sphere, which simplifies the number of states to be estimated." 876 1413 W3037280355.pdf 2 20 separator 0.9968789 ¶ 1413 1415 W3037280355.pdf 2 21 table 0.9727081 "Table 1 PPP Error budget (Choy 2018 ) Error source Error (m) Ionosphere delay 10–20 Troposphere delay 1–10 Relativistic 10 Multipath 1.0 Receiver measurement noise 0.1–0.7 SV orbit/clock /CAN0.01–0.1 Satellite phase centre variation 0.05–1 Solid earth tide 0.2 Ocean loading 0.05 Phase wind-up (ionosphere-free) 0.1 Receiver phase centre variation 0.001–0.01" 1415 1834 W3037280355.pdf 2 22 separator 0.94587386 ¶ 1834 1836 W3037280355.pdf 2 23 text 0.99575955 "The ambiguities estimated are float only. The mathematical model for IF PPP can be written as (Parkinson and Spilker 1996 ):" 1836 1964 W3037280355.pdf 2 24 separator 0.9912496 ¶ 1964 1966 W3037280355.pdf 2 25 table 0.4698419 PD 1966 1969 W3037280355.pdf 2 26 math 0.4460939 / 1969 1970 W3037280355.pdf 2 27 table 0.4597774 SUBC 1970 1974 W3037280355.pdf 2 28 math 0.4459556 c. 1974 1976 W3037280355.pdf 2 29 table 0.46799397 dt r 1976 1981 W3037280355.pdf 2 30 math 0.4482099 / 1981 1982 W3037280355.pdf 2 31 table 0.50538915 NULdts 1982 1988 W3037280355.pdf 2 32 math 0.46170983 / 1988 1989 W3037280355.pdf 2 33 table 0.4374132 CTC 1989 1992 W3037280355.pdf 2 34 math 0.4664135 c/DLE ¶ 1992 1999 W3037280355.pdf 2 35 table 0.5207986 "Br p/NULBs p" 1999 2016 W3037280355.pdf 2 36 math 0.46901053 / 2016 2017 W3037280355.pdf 2 37 table 0.45520076 DC1 2017 2021 W3037280355.pdf 2 38 math 0.59217215 "¶ CeP (3) 'D/SUBCc. dt r/NULdts/CTCc/DLE Br '/NULBs '/DC1 CN/NAKCe' (4)" 2021 2104 W3037280355.pdf 2 39 separator 0.9746504 ¶ 2104 2106 W3037280355.pdf 2 40 text 0.99643713 "In Eqs. ( 3)a n d( 4),dtrand dtsare the receiver clock error and satellite clock errors resp ectively, T is the tropospheric delay, Br pandBs pare the code bias for receiver and satellite, Br 'andBs 'are the phase bias for receiver and satellite, eP and e®are the unmodelled errors in pseudorange and carrier phase measurements, and N/NAKis the ambiguity term between the receiver and satellite on phase measurements." 2106 2544 W3037280355.pdf 2 41 separator 0.98826545 ¶ 2544 2546 W3037280355.pdf 2 42 text 0.62871283 Figure 2546 2553 W3037280355.pdf 2 43 caption 0.53378505 2 2553 2555 W3037280355.pdf 2 44 text 0.6242878 provides the representation of the E 2555 2591 W3037280355.pdf 2 45 caption 0.5471856 KF integra 2591 2601 W3037280355.pdf 2 46 text 0.58867186 - ¶ 2601 2604 W3037280355.pdf 2 47 caption 0.56412345 tion of the G 2604 2618 W3037280355.pdf 2 48 text 0.5339585 NSS 2618 2621 W3037280355.pdf 2 49 caption 0.53599393 -PPP and 2621 2630 W3037280355.pdf 2 50 text 0.6495687 IMU. 2630 2634 W3037280355.pdf 2 51 separator 0.9748142 ¶ 2634 2636 W3037280355.pdf 2 52 text 0.9990566 "In Fig. 2,fb,wbare the IMU specific force and turn rate measurements. These meas urements are converted into position PIMU, velocity VIMUand attitude AIMUfrom a known position, velocity and attitude by applying IMU mecha- nization process. Predicted /SUBIMU,®IMU are constructed by using the satellite position and velocity, which are corrected by applying the precise orbit and clock corrections. DF code and phase measurements /SUBGNSS,®GNSS are corrected for typical errors such as the errors mentioned in Table 1." 2636 3169 W3037280355.pdf 2 53 separator 0.9469013 ¶ 3169 3171 W3037280355.pdf 2 54 text 0.9483951 "The estimated output from the EKF are the error in IMU position ırn, velocity ıvnattitude ı""nand biases bgand ba. Pe IMU;Ve IMU andAe IMU give the final IMU position, velocity and attitude." 3171 3372 W3037280355.pdf 2 55 separator 0.9171349 ¶ 3372 3374 W3037280355.pdf 2 56 text 0.99878806 "The state vector consists of the navigation states, IMU states, and the GNSS only states. Navigation states include position error, velocity error and attitude error. While the inertial states consist of accelerometer and gyroscope biases." 3374 3620 W3037280355.pdf 2 57 separator 0.9193616 ¶ 3620 3622 W3037280355.pdf 2 58 text 0.99941736 The GNSS states estimated ar e: GNSS receiver clock, as well 3622 3683 W3037280355.pdf 2 0 paratext 0.98146653 "Jiang et al. /one.tnum/zero.tnum./three.tnum/three.tnum/eight.tnum/nine.tnum/fnins./two.tnum/zero.tnum/two.tnum/three.tnum./one.tnum/one.tnum/eight.tnum/zero.tnum/six.tnum/seven.tnum/nine.tnum /one.tnum." 0 205 W4378782816.pdf 1 1 title 0.69645846 Introduction 205 218 W4378782816.pdf 1 2 separator 0.9902212 ¶ 218 220 W4378782816.pdf 1 3 text 0.99964017 "Epilepsy is one of the most common chronic neurological diseases, affecting more than 70 million people worldwide, accounting for 0.5% of the global disease burden, and affecting a broad population of people of all ages, races, social classes and geographic locations ( Fiest et al., 2017 ;Feigin et al., 2019 ;Thijs et al., 2019 ;Trinka et al., 2019 ;Beghi, 2020 ). For most patients with epilepsy, treatment with antiepileptic drugs is the mainstay of treatment, with the aim of stopping seizures as early as possible withoutcausingsideeffectsthatcanaffectqualityoflife.However, more than half of patients taking epilepsy drugs still have seizures, according to surveys in the United States in 2013 and 2015 ( Tian et al., 2018 ). Although antiepileptic drugs may suppress seizures in up to two-thirds of patients, up to one-third of patients with epilepsy may still have drug-resistant epilepsy. For drug-resistant epilepsy, especially for focal epilepsy, surgical resection of the epileptogenic foci may be a more effective method. With surgery to remove or disconnect restrictive brain regions, patients can achieve complete seizure control or at least stop them. In carefully selected groups, 50–80% of individuals were seizure-free after surgery(Ryvlinetal.,2014 ).Surgeryappearstobecost-effectiveand superior to optimal medical therapy in terms of epilepsy control andqualityoflife( Wiebeetal.,2001 ;Engeletal.,2012 ;Picotetal., 2016;Dwivedi et al., 2017 ). The benefits of successful surgery also include a reduced risk of injury or premature death, opportunities to drive, greater independence, and potentially improved career choices. Therefore, surgical treatment decisions are critical for the treatmentofdrug-resistantfocalepilepsy." 220 2012 W4378782816.pdf 1 4 separator 0.9867722 ¶ 2012 2014 W4378782816.pdf 1 5 text 0.9996641 "Temporal lobe epilepsy (TLE) in drug-resistant focal epilepsy is the most common type of epilepsy in children and adults (Goubran et al., 2016 ). TLE is mostly associated with lesions of the temporal cortex, and the most common pathological type is hippocampalsclerosis(HS),accountingforapproximately50–83% of TLE cases ( Mueller et al., 2007 ). More than 70% of HS epilepsy patients can be cured by surgical resection of the hippocampus (Granados Sanchez and Orejuela Zapata, 2018 ). Therefore, HS servesasamajorhistopathologicalhallmarkandmajorunderlying etiology of TLE ( Blumcke et al., 2017 ). Notably, misdiagnosis of HS early in the disease course may lead to surgical delays, which are associated with cumulative brain damage, cognitive decline, and increased risk of disability and death, as well as significant socioeconomicconsequences( Wiebeetal.,2001 ).Therefore,oneof thekeystochoosingasurgicaltreatmentpathforTLEistoquickly andaccuratelydiscriminateHS." 2014 3011 W4378782816.pdf 1 6 separator 0.9795584 ¶ 3011 3013 W4378782816.pdf 1 7 text 0.99971586 "At present, MRI is mainly used as a standard imaging tool to detect and diagnose epilepsy foci, and more than half of patients with drug-resistant focal epilepsy can be diagnosed with epileptogenic foci ( Berg et al., 2009 ;Hakami et al., 2013 ;Duncan et al., 2016 ). Among them, the imaging features of HS on MRI may include marked atrophy on coronal T1-weighted images, hyperintensity on T2-weighted and FLAIR images, and loss of definition of the internal structures of the hippocampus ( Coras et al., 2014 ). In the diagnosis of HS in China, radiologists mainly useMRItovisuallydiagnoseHSandperformavisualinspectionor quantitative measurement of lesions such as hippocampal atrophy and hippocampal signal increase. The accuracy of diagnosisdependsonthedoctor’sexperienceandimagingquality.Physicians with imaging experience in diagnosing epilepsy are quite different in terms of diagnosing HS from those with little or no relevant experience ( Azab et al., 2015 ). Regarding the quality of MRI, some studies have shown that the performance of 3.0T MR in detecting HSisbetterthanthatof1.5TMR( Coanetal.,2014 )." 3013 4156 W4378782816.pdf 1 8 separator 0.98052824 ¶ 4156 4158 W4378782816.pdf 1 9 text 0.99970406 "Considering that in the actual diagnosis process, especially in primary hospitals, clinical facilities rarely have 3.0T and higher-performanceMRinstruments,theconventionalacquisition equipment is 1.5T MR, and most of the obtained medical images areoflowresolution(LR).Intheinitialscreeningtest,considering acquisition time, cost, and efficiency, conventional MR imaging sequences have mainly been used, with slice thicknesses ranging from 3 to 10 mm, with intervals, and few thin-slice sequences (i.e., slice thicknesses ≤1 mm) without intervals. Furthermore, as for the doctors’ experience, it is impossible for primary hospital physicians or junior physicians to have enough solid experience to accuratelydiscriminateHS.Thisisagreatchallengeforphysicians in primary hospitals or junior doctors to diagnose HS with conventionalMRsequences,whileitisthekeytowhetherpatients can be promptly transferred to high-level hospitals or undergo surgicaltreatment." 4158 5141 W4378782816.pdf 1 10 separator 0.9708072 ¶ 5141 5143 W4378782816.pdf 1 11 text 0.9994552 "With the development of computer vision technology and artificial intelligence, there are an increasing number of studies using computer-aided discrimination of HS. Current studies mainlyuseMRIsequenceswiththinthickness( ≤1mmthickness) of good quality 3T MR images to extract imaging histology featuresandlaterconstructmachinelearningclassificationmodels (Mo et al., 2019 ). Other studies have used computer vision techniquestoautomaticallymeasurefeaturessuchashippocampal volume and symmetry in MRI and construct machine learning classification models to discriminate HS ( Mettenburg et al., 2019 )." 5143 5759 W4378782816.pdf 1 12 separator 0.80192834 ¶ 5759 5761 W4378782816.pdf 1 13 text 0.99954355 "Furthermore, some studies have used deep learning to reconstruct low-resolution MRI images into high-resolution images for HS differential diagnosis ( Cao et al., 2021 ). Based on our knowledge, no studies based on real clinical MRI common sequences using computer vision or deep learning to discriminate HS have been published." 5761 6099 W4378782816.pdf 1 14 separator 0.97997373 ¶ 6099 6101 W4378782816.pdf 1 15 text 0.99945503 "This study attempted to mimic the real clinical diagnosis process of HS, construct a deep learning model, namely, HS- Net, using real-world clinical routine MRI sequences with pathological findings as the gold standard to assist primary hospital physicians or junior doctors in rapidly discriminating HS in patients with TLE, explore the feasibility of using deep learning algorithms to discriminate HS from conventional MRI sequences,andprovideradiologicalevidencefortheactualclinical identificationofHS." 6101 6621 W4378782816.pdf 1 16 separator 0.874212 ¶ 6621 6623 W4378782816.pdf 1 17 paratext 0.96311593 "/two.tnum. Materials and methods /two.tnum./one.tnum." 6623 6679 W4378782816.pdf 1 18 title 0.9293872 Study design 6679 6692 W4378782816.pdf 1 19 separator 0.9958646 ¶ 6692 6694 W4378782816.pdf 1 20 text 0.9991071 "This study explores the use of computer vision to assist clinicians in discriminating HS based on a real clinical diagnostic process. As shown in Figure1, in the actual diagnostic process, the physician first asks the patient about his or her condition" 6694 6952 W4378782816.pdf 1 21 separator 0.983163 ¶ 6952 6954 W4378782816.pdf 1 22 paratext 0.9775082 Frontiersin Neuroscience /zero.tnum/two.tnum frontiersin.org 6954 7015 W4378782816.pdf 1 0 paratext 0.97041684 Page 8 of 20 Wang et al. Diabetology & Metabolic Syndrome (2024) 16:49 0 80 W4392159436.pdf 7 1 separator 0.98864675 ¶ 81 83 W4392159436.pdf 7 2 caption 0.98278356 Fig. 2 (See legend on previous page.) 83 121 W4392159436.pdf 7 0 paratext 0.9753445 "ISSN: 2614 -6754 (print) ISSN: 2614 -3097(online) Halaman 1168 -1172 Volume 7 Nomor 1 Tahun 2023 ¶ Jurnal Pendidikan Tambusai 1171" 0 154 W4320725466.pdf 3 1 separator 0.9648943 ¶ 156 158 W4320725466.pdf 3 2 title 0.924352 Tabel 3 . Kisi -Kisi Instrumen ahli Materi 159 202 W4320725466.pdf 3 3 table 0.5126496 204 205 W4320725466.pdf 3 4 separator 0.62599784 ¶ 205 206 W4320725466.pdf 3 5 table 0.856807 "¶ No Kriteria Indikator 1. ¶ ¶ Aspek Kelayakan Isi Kesesuaian materi dengan KD Keakuratan materi Kemuktahiran Materi Mendorong Keingintahuan Menemukan dan" 208 401 W4320725466.pdf 3 6 text 0.48572063 menje 401 407 W4320725466.pdf 3 7 table 0.65352607 "laskan strategi dalam menyelesaiakan masalah Mengungkapkan ide melalui lisan atau tulisan Mengevaluasi argument ¶" 407 537 W4320725466.pdf 3 8 text 0.48990366 Menyelesai 537 548 W4320725466.pdf 3 9 table 0.517121 kan s 548 553 W4320725466.pdf 3 10 text 0.57125485 "uatu masalah dengan berbagai" 553 584 W4320725466.pdf 3 11 table 0.5294919 584 585 W4320725466.pdf 3 12 text 0.5896852 macam cara 585 595 W4320725466.pdf 3 13 separator 0.9755856 ¶ 597 599 W4320725466.pdf 3 14 title 0.6997313 2. Aspek Kelayakan 599 618 W4320725466.pdf 3 15 table 0.75098 "¶ Penyajian Teknik penyajian Pendukung penyajian ¶" 619 677 W4320725466.pdf 3 16 text 0.5083769 Koheren 677 685 W4320725466.pdf 3 17 table 0.7127426 si dan keruntutan alur berpikir 685 716 W4320725466.pdf 3 18 separator 0.82881474 ¶ 718 720 W4320725466.pdf 3 19 title 0.7161029 3. Aspek Kelayakan 720 739 W4320725466.pdf 3 20 table 0.48472863 740 741 W4320725466.pdf 3 21 separator 0.43610522 ¶ 741 742 W4320725466.pdf 3 22 table 0.7141324 "Bahasa Lugas Komunikatif, Dialogis dan Interaktif ¶" 742 801 W4320725466.pdf 3 23 text 0.49008158 Ke 801 804 W4320725466.pdf 3 24 table 0.5005939 sesuai 804 810 W4320725466.pdf 3 25 text 0.55242234 an dengan 810 819 W4320725466.pdf 3 26 table 0.5548013 ka 819 822 W4320725466.pdf 3 27 text 0.49104849 idah 822 826 W4320725466.pdf 3 28 table 0.60332954 bahasa ¶ 826 837 W4320725466.pdf 3 29 text 0.64603883 Penggunaan notasi, simbol/lambing 837 871 W4320725466.pdf 3 30 separator 0.92417544 ¶ ¶ 873 879 W4320725466.pdf 3 31 title 0.9519131 Tabel 4 . Validasi ahli Media 879 909 W4320725466.pdf 3 32 separator 0.74598897 ¶ ¶ 911 917 W4320725466.pdf 3 33 table 0.99476033 "No Aspek Penilaian Hasil Validitas (%) Kategori 1 Kegrafikan 90% Sangat Valid 2 Isi 88% Sangat Valid 3 Kebahasaan 90% Sangat Valid Jumlah Rata -rata 89% Sangat Valid" 917 1106 W4320725466.pdf 3 34 separator 0.681524 ¶ ¶ 1108 1114 W4320725466.pdf 3 35 text 0.96690834 "Gambaran tabel diatas, disimpulkan tiga aspek penilaian pada validitas media dapat diuraikan sebagai berikut : 1) Kegrafikan dengan skor 90 % kategori sangat valid, 2 ) Isi dengan skor 88 %, dan 3 ) Kebahasaan dengan skor 90 % kategori sangat valid. Sehingga rata-rata keseluruhannya 8 9% pada kategori sangat valid." 1114 1441 W4320725466.pdf 3 36 separator 0.9893595 ¶ ¶ 1443 1449 W4320725466.pdf 3 37 title 0.91164845 Tabel 4. Validasi ahli 1449 1472 W4320725466.pdf 3 38 table 0.49175122 Materi 1472 1479 W4320725466.pdf 3 39 separator 0.692359 ¶ 1481 1483 W4320725466.pdf 3 40 table 0.9949213 "No Aspek Penilaian Hasil Validitas (%) Kategori 1 Kelayakan Isi 87,6% Sangat Valid 2 Penyajian Bahan 88% Sangat Valid 3 Kebahasaan 87% Sangat Valid Jumlah Rata -rata 87.5% Sangat Valid" 1483 1694 W4320725466.pdf 3 41 separator 0.48623416 1696 1697 W4320725466.pdf 3 42 table 0.46778736 ¶ 1697 1698 W4320725466.pdf 3 43 separator 0.5904782 ¶ 1700 1702 W4320725466.pdf 3 44 text 0.90128285 "Gambaran tabel diatas, disimpulkan tiga aspek penilaian pada validitas media dapat diuraikan sebagai berikut : 1) Kelayakan Isi dengan skor 87,6 % kategori sangat valid, 2 ) Penyajian bahan dengan skor 88 %, dan 3 ) Kebahasaan dengan skor 87% kategori sangat valid. Sehingga rata -rata keseluruhannya 8 7,5% pada kategori sangat valid." 1702 2048 W4320725466.pdf 3 45 separator 0.86534953 ¶ 2050 2052 W4320725466.pdf 3 46 text 0.9921841 "Sehingga hasil gabungan antara tabel validasi media dan validasi materi dapat dilihat validitas e -modul pembelajaran gaun pesta yaitu 88% dengan kategori Sangat Valid." 2052 2227 W4320725466.pdf 3 0 paratext 0.895653 1 0 1 W4361831725.pdf 0 1 separator 0.9947604 ¶ 2 4 W4361831725.pdf 0 2 title 0.97716963 Supplemental figure legends 4 32 W4361831725.pdf 0 3 caption 0.71388376 "Figure S1: ROC1 silencing induced cell sene scence in p53-null H 1299 cells and H1299- p53 " 33 128 W4361831725.pdf 0 4 separator 0.63012505 ¶ 128 129 W4361831725.pdf 0 5 caption 0.54149646 ts 129 133 W4361831725.pdf 0 6 text 0.9420095 "cells. H1299 cells were infected with LT-ROC 1, along with LT-CONT for 72 hrs. Cells were then split and cultured for 120 hrs, followed by IB analysis (A), morphological observation under green fluorescence (C), and SA– β–gal staining (D). H1299-p53ts cells were infected with LT-ROC1 or LT-CONT for 72 hrs, then sp lit and incubated at either 37°C (mutant p53 conformation) or 32°C (wild type p53 conformation) for 120 hrs followed by IB analysis (B), and SA –β–gal staining of cells cultured at 37°C (mutant p53 conformation)" 133 677 W4361831725.pdf 0 7 caption 0.5855943 (E 677 680 W4361831725.pdf 0 8 text 0.71631455 ). 680 682 W4361831725.pdf 0 9 separator 0.9798492 ¶ 683 685 W4361831725.pdf 0 10 text 0.85670626 Representative results of three i ndependent experiments were shown. 685 754 W4361831725.pdf 0 11 separator 0.99588156 ¶ 755 757 W4361831725.pdf 0 12 caption 0.82104754 "Figure S2: siROC1 oligonucleot ide inhibited cancer cell growth by inducing apoptosis, G2/M arrest and senescence. The U87 cells and H1299 cells we re trans" 757 917 W4361831725.pdf 0 13 text 0.54614526 fected with siROC1 ¶ 917 938 W4361831725.pdf 0 14 caption 0.5694103 938 939 W4361831725.pdf 0 15 text 0.5764777 along with siCONT (40 939 962 W4361831725.pdf 0 16 caption 0.5913451 n 962 963 W4361831725.pdf 0 17 text 0.53323215 M 963 964 W4361831725.pdf 0 18 caption 0.8429242 ") using Lipofect amine 2000 for 48 hrs, followed by immunoblotting analysis for ROC1 levels (A), or split for ATPlite cell proliferation assay at 24, 48, 72 and 96 hrs later (B)." 964 1149 W4361831725.pdf 0 19 text 0.963342 "Shown is mean value ± SEM from three independent experiments, each run in quadruplicate. U87 cel ls were transfected with siROC1, along with siCONT, for 120 hrs and subject to FACS an alysis. Apoptosis was measured by the percentage of cells in Sub-G1 population, and shown is mean value ±SEM from three independent experiments (C). Cell cycle profile was determined in non-apoptotic cells, and representative results of three i ndependent experiments were shown (D). U87 cells were transfected with siROC1, along with siCONT, for 48 hrs, then split and subject to SA- β- galactosidase staining 96 hrs later (E). Representative result s of three independent experiments were shown." 1149 1861 W4361831725.pdf 0 0 paratext 0.98841107 Page 9 of 9 0 11 W2173199045.pdf 8 1 separator 0.99151886 ¶ 11 13 W2173199045.pdf 8 2 bibliography 0.9884562 Liu and Xu SpringerPlus (2015) 4:732 14 53 W2173199045.pdf 8 3 separator 0.987939 ¶ 54 56 W2173199045.pdf 8 4 bibliography 0.9949165 "Vijayakumar N, Subramanian E, Padiyan DP (2013) Cross-Linked Poly(Vinyl Pyrrolidone) Hard-Template and Polym- erization Method in controlling nanostructures and properties of polyaniline composites. Polym-Plast Technol 52:1220–1227" 56 293 W2173199045.pdf 8 5 separator 0.9910261 ¶ 293 295 W2173199045.pdf 8 6 bibliography 0.99777097 "Wanna Y, Pratontep S, Wisitsoraat A, Tuantranont A (2006) Development of nanofibre composite Polyaniline/CNT fabri- cated by electro spinning technique for CO gas sensor. IEEE Sens 1–3:342–345" 295 490 W2173199045.pdf 8 7 separator 0.9869232 ¶ 490 492 W2173199045.pdf 8 8 bibliography 0.9976634 "Yoo I, Song S, Uh K, Lee CW, Kim JM (2015) Size-controlled fabrication of polyaniline microfibres based on 3d hydrody- namic focusing approach. Macromol Rapid Comm 3:1272–1276" 492 670 W2173199045.pdf 8 9 separator 0.9888513 ¶ 670 672 W2173199045.pdf 8 10 bibliography 0.99725795 "Zhu XY, Hou K, Chen C, Zhang WQ, Sun HM, Zhang GF, Gao ZW (2015) Structural-controlled synthesis of polyaniline nanoarchitectures using hydrothermal method. High Perform Polym 27:207–216" 672 862 W2173199045.pdf 8 0 paratext 0.97270536 "www.nature.com/scientificreports/4 SCiENtiFiC RepoRts | (2018) 8:7261 | DOI:10.1038/s41598-018-25024-4" 0 108 W2805291611.pdf 3 1 title 0.48362616 of 108 110 W2805291611.pdf 3 2 text 0.9917991 "bonds between the calcium cation and particular functional groups responsible for this vibration. Moreover, as a result of the modification, merging signals at v = 1715 cm−1 and v = 1460 cm−1 present in the spectrum of unmodified yeast can be observed. Another characteristic band appears at v = 1377 cm−1 and derives from the stretching vibration of C-N from surface proteins. These changes are probably related to the complexation reactions between the calcium cation and O- and N- donors of proper functional group 26,27. The obtained data prove that the S . cerevisiae exhibits the ability of the sorption of divalent metal cations such as calcium ions27." 110 785 W2805291611.pdf 3 3 separator 0.9168267 ¶ 786 788 W2805291611.pdf 3 4 text 0.99957985 "Furthermore, it can be observed that the most significant changes occur in the spectrum of the yeast modified by 5 mM Ca(NO 3)2 solution at pH = 9, which is caused by the total deprotonation of -COO−, -OPO32− and -NH2 groups. These results are also confirmed by the zeta potential measurement in this study - the highest dispersion stability of the system was observed at the pH range from 8 to 10 21. Therefore, under these conditions, the tested (bio)colloid is characterized by a large active surface and the highest availability of functional groups able to bind calcium ions. This indicates that the most effective biosorption process occurs in these conditions." 788 1466 W2805291611.pdf 3 5 separator 0.9908322 ¶ 1466 1468 W2805291611.pdf 3 6 text 0.99924093 "The impact of the S. cerevisiae surface functional groups modification on their electrophoretic separation at different pH. The chosen electrolyte for the modification of the yeast surface was Ca(NO3)2 at the concentration of 5 mM. According to Dziubakiewicz et al . the type and concentration of the background electrolyte have a significant influence on the cells viability20. The number of viable cells increased along with the decrease in the electrolyte ionic strength: 0.1 M > 0.01 M > 0.005 M. To determine the effect of the surface modi- fication of S . cerevisiae on the electrophoretic mobility, the electrophoretic analysis was conducted. Figure 3 shows the electropherograms of the yeast unmodified and modified by calcium ions at different pH conditions. The electromigration time of the yeast modified by the calcium solution of pH 6, 8 and 9 was 3.099 (RSD = 4.59%), 4.013 (RSD = 4.73%) and 4.099 (RSD = 3.03%) min respectively." 1468 2437 W2805291611.pdf 3 7 separator 0.9876797 ¶ 2437 2439 W2805291611.pdf 3 8 text 0.9996603 "The results indicate that the surface modification of (bio)colloid has a significant impact on its electrophoretic mobility. This phenomenon was also observed by Pomastowski et al .28 in the case of bacteria. They stated that the change in the electrophoretic mobility of bacteria cells and the reduction of repulsive forces have resulted in clumping of cells and a signal amplification. Moreover, after the modification, the sharpening of the peaks and improvement of the shape of the base line on the electropherogram as well as the reduction in the number of aggregates and the improvement of the reproducibility can be observed; it was evidenced by a significant reduc- tion in the relative standard deviation value in comparison to unmodified yeast. Another interesting observation is the effect of pH on modified (bio)colloid behaviour during the electrophoretic analysis. With the increase in the pH of medium in which sorption was conducted, the increase in the electromigration time of modified yeast cells and as a decrease in the electrophoretic mobility (38.1 ± 2, 27.8 ± 1 and 24.5 ± 1 [10 −5 cm2Vs] for pH 6, 8 and 9, respectively) were observed (Fig. 3). However, these effects were not observed for the yeast cells incubated at different pH but without the presence of calcium ions, as demonstrated in Supplementary Fig. S4." 2439 3801 W2805291611.pdf 3 9 separator 0.98148286 ¶ 3801 3803 W2805291611.pdf 3 10 text 0.99970883 "The highest reproducibility (RSD < 5%) of the electrophoretic analysis was obtained for S . cerevisiae which was modified with Ca(NO3)2 solution at pH = 9. This phenomenon is probably connected with the total depro- tonation of surface functional groups, which is also confirmed by the results of the spectroscopic and potentio-metric analysis. The total deprotonation of active functional groups at pH = 9 causes the high dispersion stability (zeta potential measurements) and high availability of ion binding sites at the starting point of the sample prepa-ration stage, which determines the creation of stable electrokinetic clumping during the yeast cells electroanalysis." 3803 4489 W2805291611.pdf 3 11 separator 0.98167086 ¶ 4490 4492 W2805291611.pdf 3 12 text 0.99952936 "A high availability of the deprotonated functional groups on the surface of S . cerevisiae allows binding of a large amount of calcium ions which promote the formation of aggregate systems." 4492 4686 W2805291611.pdf 3 13 separator 0.9368022 ¶ 4686 4688 W2805291611.pdf 3 14 text 0.9996865 "Moreover, the study of the size of modified and non-modified yeast cells at different pH ( Supplementary Fig. S5) indicates that the change occurring only in the pH of the incubation does not have a significant impact on the size distribution of the examined cells, while the modification of cells by calcium causes the unification of their size. This phenomenon may also contribute to the improvement of their electrophoretic separation." 4688 5137 W2805291611.pdf 3 15 separator 0.9870026 ¶ 5137 5139 W2805291611.pdf 3 16 text 0.99931526 "Microscopic and spectrometric studies of modified and non-modified yeasts were performed in order to high- light the changes in the molecular profile of (bio)colloids under different pH conditions." 5139 5339 W2805291611.pdf 3 17 separator 0.93401694 ¶ 5339 5341 W2805291611.pdf 3 18 text 0.9995398 "The MALDI-TOF MS spectra of yeast incubated at different pH (6, 8 and 9) without calcium ions are present in Supplementary Fig. S6. As it can be observed the incubation of S . cerevisiae at different pH does not signifi- cantly affect their molecular profile in comparison to the control - S . cerevisiae sample taken directly from growth media. On the obtained spectra only slight changes can be observed. What may be observed is the appearance of" 5341 5800 W2805291611.pdf 3 19 separator 0.84413517 ¶ 5801 5803 W2805291611.pdf 3 20 caption 0.99648905 Figure 2. The FTIR spectra of unmodified and modified S. cerevisiae pellets at pH 6, 8 and 9. 5803 5898 W2805291611.pdf 3 0 paratext 0.976952 Open Peer Review on Qeios 0 25 W4254807282.pdf 0 1 separator 0.70857525 ¶ 25 27 W4254807282.pdf 0 2 paratext 0.92465085 Open Peer Review on Qeios 27 53 W4254807282.pdf 0 3 separator 0.96170247 ¶ 53 55 W4254807282.pdf 0 4 title 0.9848439 Sheep Red Blood Cell Rosetting 55 86 W4254807282.pdf 0 5 separator 0.9536449 ¶ 86 88 W4254807282.pdf 0 6 title 0.82744044 National Cancer Institute 88 114 W4254807282.pdf 0 7 separator 0.9702371 ¶ 114 116 W4254807282.pdf 0 8 paratext 0.60590935 Source 116 123 W4254807282.pdf 0 9 separator 0.79170036 ¶ 123 125 W4254807282.pdf 0 10 bibliography 0.3672086 National 125 134 W4254807282.pdf 0 11 paratext 0.38299447 Cancer Institute 134 151 W4254807282.pdf 0 12 bibliography 0.38617352 . 151 152 W4254807282.pdf 0 13 separator 0.9244091 ¶ 153 155 W4254807282.pdf 0 14 title 0.6890856 Sheep Red Blood Cell Rosetting 155 186 W4254807282.pdf 0 15 separator 0.48964083 ¶ 186 188 W4254807282.pdf 0 16 bibliography 0.49007073 . NCI Thesaurus. Code C72897. 188 218 W4254807282.pdf 0 17 separator 0.9760963 ¶ 218 220 W4254807282.pdf 0 18 text 0.8778013 A technique for identifying and removing T lymphocytes based on their ability to form 220 307 W4254807282.pdf 0 19 separator 0.5281991 ¶ 307 308 W4254807282.pdf 0 20 text 0.89630884 rosettes with untreated sheep erythrocytes. 308 352 W4254807282.pdf 0 21 separator 0.97645175 ¶ 352 354 W4254807282.pdf 0 22 paratext 0.94260156 "Qeios · Definition, February 7, 2020" 354 398 W4254807282.pdf 0 23 separator 0.5865819 398 399 W4254807282.pdf 0 24 paratext 0.96193314 ¶ Qeios ID: I0YS6R · https://doi.org/10.32388/I0YS6R 399 455 W4254807282.pdf 0 25 separator 0.4839564 455 456 W4254807282.pdf 0 26 paratext 0.8813397 "¶ 1 /" 456 463 W4254807282.pdf 0 27 separator 0.86718464 ¶ 463 465 W4254807282.pdf 0 28 paratext 0.53425604 1 465 467 W4254807282.pdf 0 0 paratext 0.9755844 "Agunyo, M. F., et al. Exploring the Environmental Feasibility of ... Year 2019 Volume 7, Issue 1, pp 28-43" 0 114 W2806643524.pdf 9 1 separator 0.5347855 ¶ 116 118 W2806643524.pdf 9 2 paratext 0.91680855 ¶ Journal of Sustainable Development of Energy, Water and Environment Systems 37 120 205 W2806643524.pdf 9 3 title 0.991481 Life cycle impact assessment 206 235 W2806643524.pdf 9 4 separator 0.99493617 ¶ 236 238 W2806643524.pdf 9 5 text 0.99924815 "This stage of the LCA aims at assessing the life cy cle inventory to better understand the environmental significance of the sanitation sy stems. Thus, assessment of the environmental impacts arising from the life cycle i nventory was carried out." 238 492 W2806643524.pdf 9 6 separator 0.7587404 ¶ 494 496 W2806643524.pdf 9 7 text 0.9989236 "To accomplish this task, environmental impact categ ories were assigned for the inputs and outputs to the sanitation systems. The impact c ategory indicators were then used to explain the inventory results. As such, the mandato ry steps which include classification and characterization of the impact categories was c arried out using the CML 2001 impact assessment methodology in Gabi 6 software [21, 31]. Given that no agreed universal list of impact categories exists for carrying out such L CAs, the following set was selected; Global Warming (GWP), Eutrophication Potential (EP) and Human Toxicity Potential (HTP). The choice of the impact categories was infl uenced by the anticipated impacts from improper management of the organic waste strea ms and the potential resource use as well as recovery from system’s operation phase c onsidered. Besides, the available impact categories in the Gabi 6 software also influ enced the final choice of impact categories." 496 1500 W2806643524.pdf 9 8 separator 0.9973253 ¶ 1502 1504 W2806643524.pdf 9 9 title 0.99336964 DISCUSSION OF RESULTS 1504 1526 W2806643524.pdf 9 10 separator 0.99574625 ¶ 1527 1529 W2806643524.pdf 9 11 text 0.99924076 "The results from computation of the environmental i mpact for the six sanitation system alternatives are summarized in Table 3. In g eneral, negative or lower impact values represent an environmentally beneficial sani tation system, while positive or higher impact values represent environmental burden s from the respective sanitation systems. The results indicated that for all sanitat ion system alternatives which consisted of AD process, much lower impact values were regist ered in comparison to the Status Quo. Meanwhile, the trend of performance for the di fferent sanitation system alternatives varied with reference to specific impact categories and the results are summarized in Table 3." 1529 2253 W2806643524.pdf 9 12 separator 0.9880503 ¶ ¶ 2254 2260 W2806643524.pdf 9 13 title 0.82760024 "Table 3. Shows the environmental impact results for sanitation system alternatives with reference to the FU" 2260 2372 W2806643524.pdf 9 14 separator 0.9358267 ¶ ¶ 2373 2379 W2806643524.pdf 9 15 table 0.9954572 "Impact Units Status Quo COMPAD COMPAD LF INCAD INTEG 1 INTEG 2 BfC CoGen BfC CoGen BfC CoGen BfC CoGen BfC CoGen GWP [kg CO 2 eq] 3.27E+5 4.18E+4 4.36E+4 4.16E+4 4.33E+4 1.35E+5 1.35E+5 3.9 3E+4 4.04E+4 4.47E+4 4.45E+4 EP [kg PO 4−3 eq] 2.58E+2 6.83E+1 8.18E+1 6.83E+1 8.18E+1 8.28E+1 8.96E+1 7.7 1E+1 8.63E+1 3.58E+1 3.88E+1 HTP [kg DCB eq] 1.71E+4 1.45E+4 1.68E+4 1.45E+4 1.68E+4 1.30E+4 1.38E+4 1.5 7E+4 1.69E+4 7.56E+3 7.50E+3" 2379 2830 W2806643524.pdf 9 16 separator 0.99520355 ¶ 2831 2833 W2806643524.pdf 9 17 title 0.99144113 Global Warming Potential 2833 2858 W2806643524.pdf 9 18 separator 0.9953902 ¶ 2860 2862 W2806643524.pdf 9 19 text 0.9996238 "The Status Quo sanitation system registered the highest GWP value followed by INCAD, INTEG 2, COMPAD, COMPAD LF while INTEG 1 alt ernative performed best, registering the least GWP value. A summary of proce sses contribution to GWP and the respective emissions from the sanitation systems is represented in Table 4. Moreover, for the sanitation systems which consisted of the AD un it, significant reduction in GWP was attained when substitution of firewood with biogas as a cooking fuel was considered and this accounted for a reduction in GWP of upto −1,340 kg CO 2 eq. Meanwhile, the substitution of artificial fertilizer with compost and digestate as organic fertilizer contributed to reduction in GWP of at least −1,210 kg CO 2 eq." 2862 3625 W2806643524.pdf 9 20 separator 0.98351526 ¶ ¶ 3627 3633 W2806643524.pdf 9 21 title 0.95941263 Table 4. Shows a summary of process contribution to GWP 3633 3690 W2806643524.pdf 9 22 separator 0.8155613 ¶ 3691 3696 W2806643524.pdf 9 23 table 0.9867397 "¶ Sanitation system Process contribution to GWP [%] Re spective emissions Status Quo Dumping of residual sewage sludge (LDS) [97%] CH 4 emissions COMPAD, COMPADLF, INTEG 1, INTEG 2 AD (68%) Utilization of Firewood for Cooking (UFc) (20.8%) CH 4 CO 2" 3696 3962 W2806643524.pdf 9 0 separator 0.99648637 ¶ 1 2 W4200391341.pdf 0 1 title 0.9802456 Supplementary Material 2 25 W4200391341.pdf 0 2 separator 0.99621403 ¶ ¶ 27 33 W4200391341.pdf 0 3 caption 0.9937918 Supplementary Video 1. Dynamic evolution of a 3-D isosurface taken at normalized Q -criterion = 33 130 W4200391341.pdf 0 4 separator 0.8448868 ¶ 131 133 W4200391341.pdf 0 5 caption 0.99161774 0.3 colored by vorticity magnitude which illustrates coherent turbulence structures in the jet flow . 133 236 W4200391341.pdf 0 6 separator 0.94273776 ¶ 238 240 W4200391341.pdf 0 7 caption 0.94536644 The video is slowed by a factor of 10,000. 240 283 W4200391341.pdf 0 0 paratext 0.9750796 Open Peer Review on Qeios 0 25 W4232229978.pdf 0 1 separator 0.7181108 ¶ 25 27 W4232229978.pdf 0 2 paratext 0.900023 Open Peer Review on Qeios 27 53 W4232229978.pdf 0 3 separator 0.9456328 ¶ 53 55 W4232229978.pdf 0 4 title 0.90314966 "Malignant Neoplasm of the Abdominal Esophagus" 55 103 W4232229978.pdf 0 5 separator 0.9396852 ¶ 103 105 W4232229978.pdf 0 6 title 0.5706957 National Cancer Institute 105 131 W4232229978.pdf 0 7 separator 0.9495479 ¶ 131 133 W4232229978.pdf 0 8 paratext 0.7407041 Source 133 140 W4232229978.pdf 0 9 separator 0.83629227 ¶ 140 142 W4232229978.pdf 0 10 paratext 0.5950643 National Cancer Institute. 142 169 W4232229978.pdf 0 11 separator 0.9614804 ¶ 170 172 W4232229978.pdf 0 12 title 0.56309164 Malignant Neoplasm of the Abdominal Esophagus 172 218 W4232229978.pdf 0 13 separator 0.44328368 ¶ 218 220 W4232229978.pdf 0 14 paratext 0.52064407 . NCI 220 226 W4232229978.pdf 0 15 separator 0.30783045 ¶ 226 228 W4232229978.pdf 0 16 paratext 0.55828905 Thesaurus. Code C4764. 228 251 W4232229978.pdf 0 17 separator 0.9936557 ¶ 251 253 W4232229978.pdf 0 18 text 0.93386763 "A primary or metastatic malignant neoplasm involving the abdominal region of the esophagus." 253 347 W4232229978.pdf 0 19 separator 0.9777616 ¶ 347 349 W4232229978.pdf 0 20 paratext 0.9335249 "Qeios · Definition, February 7, 2020" 349 393 W4232229978.pdf 0 21 separator 0.6547899 393 394 W4232229978.pdf 0 22 paratext 0.93050236 "¶ Qeios ID: R7PZK0 · https://doi.org/10.32388/R7PZK0 1 /" 394 458 W4232229978.pdf 0 23 separator 0.75741005 ¶ 1 458 462 W4232229978.pdf 0 0 title 0.97104055 supporting information 0 22 W2246663845.pdf 7 1 separator 0.9879912 ¶ 22 24 W2246663845.pdf 7 2 paratext 0.8213884 sup-7 Acta Cryst. (2012). E 68, o2010 24 63 W2246663845.pdf 7 3 table 0.99457175 "C10—N1—N2—C9 −1.1 (5) C10—N1—C8—C7 55.1 (7) C8—N1—N2—C9 −179.7 (4) N2—N1—C8—C7 −126.5 (5)C6—C1—C2—C3 −0.2 (9) C10—N1—C8—C11 −126.2 (5)C1—C2—C3—F1 −179.8 (5) N2—N1—C8—C11 52.2 (6)C1—C2—C3—C4 3.1 (10) C10—N3—C9—N2 0.0 (6)C2—C3—C4—C5 −3.4 (10) N1—N2—C9—N3 0.6 (6)F1—C3—C4—C5 179.6 (6) C9—N3—C10—N1 −0.7 (5)C3—C4—C5—F2 −178.2 (6) N2—N1—C10—N3 1.1 (5)C3—C4—C5—C6 0.6 (10) C8—N1—C10—N3 179.6 (4)F2—C5—C6—C1 −179.2 (5) C7—O1—C12—C13 −179.3 (4)C4—C5—C6—C1 2.0 (9) O1—C12—C13—C14 −68.8 (6)F2—C5—C6—C7 1.8 (8) C15—O2—C14—C13 179.2 (4)C4—C5—C6—C7 −177.0 (6) C12—C13—C14—O2 180.0 (4)C2—C1—C6—C5 −2.2 (8) C14—O2—C15—C20 −2.6 (7)C2—C1—C6—C7 176.7 (5) C14—O2—C15—C16 178.6 (4)C12—O1—C7—C8 −158.1 (5) O2—C15—C16—C17 178.8 (5)C12—O1—C7—C6 21.7 (6) C20—C15—C16—C17 −0.1 (8)C5—C6—C7—C8 −113.0 (6) C15—C16—C17—C18 −0.2 (8)C1—C6—C7—C8 68.1 (7) C16—C17—C18—C19 0.2 (8)C5—C6—C7—O1 67.2 (7) C16—C17—C18—Br 179.5 (4)C1—C6—C7—O1 −111.7 (6) C17—C18—C19—C20 0.1 (8)O1—C7—C8—N1 7.3 (7) Br—C18—C19—C20 −179.3 (4)C6—C7—C8—N1 −172.5 (4) C18—C19—C20—C15 −0.3 (9)O1—C7—C8—C11 −171.2 (5) O2—C15—C20—C19 −178.5 (5)C6—C7—C8—C11 9.0 (9) C16—C15—C20—C19 0.3 (8)" 66 1191 W2246663845.pdf 7 4 separator 0.9934783 ¶ 1191 1193 W2246663845.pdf 7 5 title 0.82015556 Hydrogen-bond geometry (Å, 1193 1220 W2246663845.pdf 7 6 table 0.45979062 o) 1220 1223 W2246663845.pdf 7 7 separator 0.9692111 ¶ 1225 1227 W2246663845.pdf 7 8 table 0.9387329 "D—H··· AD —H H··· AD ···AD —H··· A N3—H3 A···O4 0.86 1.95 2.790 (6) 167 C9—H9 A···O3i0.93 2.55 3.271 (7) 135 C10—H10 A···O3ii0.93 2.49 3.263 (7) 140 C10—H10 A···O5ii0.93 2.42 3.340 (7) 168 C19—H19 A···O3 0.93 2.54 3.276 (7) 137" 1227 1465 W2246663845.pdf 7 9 separator 0.9796745 ¶ 1465 1467 W2246663845.pdf 7 10 table 0.45695668 Sym 1467 1471 W2246663845.pdf 7 11 text 0.4083866 metry codes 1471 1482 W2246663845.pdf 7 12 math 0.60957694 : (i) − x+2, − y+1, − z+1; (ii) − x+1, − y+1, − z+1. 1482 1534 W2246663845.pdf 7 0 paratext 0.9867889 www.nature.com/scientificreports/12 0 35 W2769120433.pdf 11 1 separator 0.66646695 ¶ 35 37 W2769120433.pdf 11 2 paratext 0.9761776 SCIentIFIC RepoRts | 7: 16360 | DOI:10.1038/s41598-017-16611-y 37 103 W2769120433.pdf 11 3 separator 0.9949542 ¶ 103 105 W2769120433.pdf 11 4 caption 0.9440695 "Figure 7. In vitro and in vivo differentiation potential of LIF-independent iOCT4 ES cells (A) Schematic of " 105 219 W2769120433.pdf 11 5 text 0.9294457 "experimental design. To induce differentiation, OCT4-inducible (iOCT4) ES cells were grown in the absence of LIF and with doxycycline to downregulate OCT4 expression on low-binding dishes or as a monolayer. (B) Embryoid" 219 441 W2769120433.pdf 11 6 caption 0.49594152 body 441 446 W2769120433.pdf 11 7 text 0.60355383 ( 446 448 W2769120433.pdf 11 8 caption 0.72559965 EB) differentiation of control ES cells (ZHTc6) and LIF-independent iOCT4 ES cells. 448 531 W2769120433.pdf 11 9 text 0.92769533 "(C) Teratomas generated from LIF-independent iOCT4 ES cells injected into SCID-beige mice, which were treated with tetracycline (Tc) to downregulate OCT4 expression. (D) Teratomas generated from wild-type ES cells (R1) injected into SCID-beige mice. Tumors were harvested 4–6 weeks post injection and evaluated using standard H&E histological methods. Transmitted white-light microscopy of sectioned teratomas. Heterogeneous differentiation of LIF-independent iOCT4 ES cells and control ES cells into endoderm (glandular structures), mesoderm (osteoblasts, adipocytes, muscle), and ectoderm (keratinized epidermal cells). (E,F) Differentiation of" 531 1184 W2769120433.pdf 11 10 caption 0.56499267 1184 1185 W2769120433.pdf 11 11 text 0.50123554 LIF 1185 1188 W2769120433.pdf 11 12 caption 0.51507485 -independent 1188 1200 W2769120433.pdf 11 13 text 0.51527685 1200 1201 W2769120433.pdf 11 14 caption 0.64075494 iOCT4 ES cells in the presence of doxycycline to downregulate 1201 1263 W2769120433.pdf 11 15 text 0.5180496 OCT 1263 1266 W2769120433.pdf 11 16 caption 0.51266545 4 expression and 1266 1282 W2769120433.pdf 11 17 text 0.5704925 (E 1282 1285 W2769120433.pdf 11 18 caption 0.5017937 ) 1285 1287 W2769120433.pdf 11 19 text 0.6087315 without or ( F) with retinoic acid 1287 1321 W2769120433.pdf 11 20 caption 0.4904449 . 1321 1322 W2769120433.pdf 11 0 text 0.9988966 "Urban Rail Transit system is a complex network having a defined topological relations, The Urban Rail Transit system network methods include the R Space method and the L, P Space method. The R Space method is to track the rail-line as a complex network node, and the site of line intersects as a complex network link, the number of the site what two lines intersecting as a complex network connection weights, to construct the R spatial network model. In contrast, the L, P Sp ace method is to track the site as a complex network node, and the rail-line as the complex network link, so this method is a direct mapping to track network. the configuration differences of the L,P Space method as follows:" 0 738 W2535238560.pdf 1 1 separator 0.8601997 ¶ 739 741 W2535238560.pdf 1 2 text 0.98047733 "(1). The L space network model. The network model is a direct mapping of the rail network diagram that if two adjacent sites in a track circuit, then connect it with the link. (2). The P space network mo del. When two sites are connected by at least one rail line, then connect it with the link. i.e. 123( , , ... )n Line p p p p /g32 , the site 1p and the sites 23, ...n pp p are to establish a connection." 741 1171 W2535238560.pdf 1 3 separator 0.98996866 ¶ 1172 1174 W2535238560.pdf 1 4 caption 0.9726769 Fig. 1 shows the display method of the L, P Spcce. 1174 1225 W2535238560.pdf 1 5 separator 0.97462344 ¶ ¶ 1226 1232 W2535238560.pdf 1 6 caption 0.99361974 Figure 1. The display method of the L, P Spcce. 1232 1281 W2535238560.pdf 1 7 separator 0.97251874 ¶ ¶ 1282 1288 W2535238560.pdf 1 8 text 0.9992042 "This paper selected the L, P spatial network method for urban rail network mapping. The L space network model is applied to study the degree distribution and network efficiency of the track network. The P space network model is suitable for the study of transfer parameters. The above two methods have their limitations respectively ˈ so this paper will combine the use of these two methods." 1288 1701 W2535238560.pdf 1 9 separator 0.822608 ¶ 1702 1704 W2535238560.pdf 1 10 text 0.9972755 "Taking into account the Urban Rail Transit system in Beijing, Shanghai, Guangzhou developed more perfect and mature, so this paper make the Urban Rail Transit networks of above three cities as the study object. Urban Rail Transit network data including line network operators table, name of the site, ID number of the site, name of the line, station location (latitude and longitude) and other items, All data items got through the Baidu maps API interface. Convert the data file for the site ID retrieval matrix, site latitude and longitude matrix, adjacency matrix and a series of data basis for complex network analysis based on the above L, P spatial network method." 1704 2412 W2535238560.pdf 1 11 separator 0.9963601 ¶ 2413 2415 W2535238560.pdf 1 12 title 0.9914822 "3 Topology homogeneity of urban rail transport network" 2415 2473 W2535238560.pdf 1 13 separator 0.98646945 ¶ 2474 2476 W2535238560.pdf 1 14 title 0.9889485 3.1 Static topological features 2476 2508 W2535238560.pdf 1 15 separator 0.9938777 ¶ 2509 2511 W2535238560.pdf 1 16 text 0.98498017 "Static topological characteristics of complex networks including degree and degree distribution, the network diameter and the average path length, betweenness and clustering coefficient." 2511 2705 W2535238560.pdf 1 17 separator 0.86045456 ¶ 2706 2708 W2535238560.pdf 1 18 text 0.80696994 "(1). Degree and degree distribution. A degree of the node i is the number of edges associated with the node i. The average degree value of ea ch node is the degree of the entire network, i.e." 2708 2910 W2535238560.pdf 1 19 math 0.89989394 "¶ () /ii iNkk k N /g143/g31/g33 /g32 /g32 /g166 (1)" 2911 2987 W2535238560.pdf 1 20 text 0.46507525 ¶ ()pk represents the probability of each node degree 2988 3042 W2535238560.pdf 1 21 math 0.43666583 ¶ 3043 3045 W2535238560.pdf 1 22 text 0.45361358 "distribution. (2). The network diameter an d the average path length." 3045 3118 W2535238560.pdf 1 23 separator 0.9274795 ¶ 3119 3121 W2535238560.pdf 1 24 text 0.9615771 "In the complex network theory, define the distance between nodes ,ijnn is the number of edges in the shortest path connecting nodes ,ijnn . The network diameter D is the maximum distance between any two nodes in the network, i.e. , max ( )ij i j Dd/g32 (2)" 3121 3422 W2535238560.pdf 1 25 separator 0.6277635 ¶ 3423 3425 W2535238560.pdf 1 26 text 0.98026025 "The average path length of the network is the average distance between all nodes." 3425 3510 W2535238560.pdf 1 27 separator 0.7137258 ¶ 3511 3513 W2535238560.pdf 1 28 text 0.9904975 "(3). Betweenness. Betweenness divided the edges betweenness and the node betweenness. The so-called edge betweenness, refers to the network between all nodes on the shortest path through which the ratio of the edge, the node betweenness and the edge betweenness have the similar meaning." 3513 3816 W2535238560.pdf 1 29 separator 0.8891461 ¶ 3817 3819 W2535238560.pdf 1 30 text 0.97614205 "(4). Clustering coefficient. clustering coefficient reflects the degree of aggregation of nodes in the network, the degree of node inis ik, i.e. adjacent to the surrounding ik nodes. If the interconnectivity between these ik nodes, even up to the " 3819 4080 W2535238560.pdf 1 31 math 0.83176243 /;#23#23#23#23#23#23#23#23#23#23#23/;#23#23#23#23#23#23#23#23#23#23#23#23 1/ 2iikk /;#23#23#23#23#23#23#23#23#23#23#23#23#23#23#23#23 links, 4080 4221 W2535238560.pdf 1 32 text 0.9350882 "¶ Suppose even number of links it actually exists is ikn, then the node clustering coefficient iC is:" 4222 4331 W2535238560.pdf 1 33 separator 0.51450616 ¶ 4333 4335 W2535238560.pdf 1 34 math 0.95380867 "/ ((1 ) ) i ik i iCn k k/g32/g117 /;#23#23#23#23#23#23#23#23#23#23#23#23#23#23#23#23 (3)" 4347 4458 W2535238560.pdf 1 35 separator 0.6515587 ¶ 4459 4461 W2535238560.pdf 1 36 text 0.6210845 "Network clustering coefficient C is the arithmetic mean of each node clustering coefficient:" 4461 4558 W2535238560.pdf 1 37 math 0.878668 "¶ 11N i iCCN /g32/g32/g166 (4)" 4560 4623 W2535238560.pdf 1 38 separator 0.9960611 ¶ 4624 4626 W2535238560.pdf 1 39 title 0.99286073 3.2 Homogeneous topology 4626 4651 W2535238560.pdf 1 40 separator 0.99571455 ¶ 4652 4654 W2535238560.pdf 1 41 text 0.99482346 "Through computer programming to Beijing, Shanghai and Guangzhou Urban Rail Transit network topology packet characteristic calculation , the specific results are shown in Table 1." 4654 4842 W2535238560.pdf 1 42 separator 0.629446 4843 4844 W2535238560.pdf 1 43 text 0.9917185 "¶ By the Table 1, it can be seen, Urban Rail Transit network scale of the three cities, but the average degree of nodes, the network diameter, the average path length, the average clustering coef ficient roughly equivalent, It illustrates the complex network topology homogeneity of the three cities." 4844 5160 W2535238560.pdf 1 44 separator 0.98221564 ¶ 5161 5163 W2535238560.pdf 1 45 paratext 0.9514317 "2/g3 ¶ DOI: 10.1051/ 01003 (2016) matecconf/201 MATEC Web of Conferences 2016,81 68101003" 5163 5267 W2535238560.pdf 1 46 separator 0.5878526 5267 5268 W2535238560.pdf 1 47 paratext 0.8585775 ¶ ICTTE 5268 5275 W2535238560.pdf 1 0 paratext 0.9896981 Page 14/17 0 10 W4312017953.pdf 13 1 separator 0.9964097 ¶ 10 12 W4312017953.pdf 13 2 caption 0.82200956 Figure 4 12 21 W4312017953.pdf 13 3 separator 0.98657215 ¶ 21 23 W4312017953.pdf 13 4 caption 0.98473763 (a) Schematic illustration of the BANN structure; (b) the loss and (c) accuracy of the BANN as a function 23 129 W4312017953.pdf 13 5 separator 0.85569876 ¶ 129 131 W4312017953.pdf 13 6 caption 0.9718967 of number of epochs during the training process. 131 180 W4312017953.pdf 13 0 separator 0.6939252 ¶ 1 5 W4239299455.pdf 0 1 paratext 0.35934898 "¶ ¶ ¶" 5 22 W4239299455.pdf 0 2 separator 0.32952723 24 25 W4239299455.pdf 0 3 paratext 0.30475622 ¶ 25 26 W4239299455.pdf 0 4 separator 0.3544394 28 29 W4239299455.pdf 0 5 paratext 0.28138065 ¶ 29 30 W4239299455.pdf 0 6 separator 0.37640905 32 33 W4239299455.pdf 0 7 paratext 0.25860298 ¶ 33 34 W4239299455.pdf 0 8 separator 0.52900714 "¶ ¶ ¶ ¶ ¶ ¶ ¶" 36 82 W4239299455.pdf 0 9 title 0.97862023 Donating Behaviour and Attitudes: An Exploratory Study of the 82 144 W4239299455.pdf 0 10 separator 0.7013478 ¶ 145 147 W4239299455.pdf 0 11 title 0.9344383 Differences in Age Cohorts 147 174 W4239299455.pdf 0 12 separator 0.68823695 "¶ ¶ ¶" 176 194 W4239299455.pdf 0 13 contact 0.9712481 "¶ Agnes Meinhard Centre for Voluntary Sector Studies, Ryerson Univer sity Mary Foster Centre for Voluntary Sector Studies, Ryerson Univer sity" 196 348 W4239299455.pdf 0 14 separator 0.5014279 349 350 W4239299455.pdf 0 15 contact 0.5880216 ¶ ¶ 350 355 W4239299455.pdf 0 16 separator 0.42298803 357 358 W4239299455.pdf 0 17 contact 0.40895966 ¶ 358 359 W4239299455.pdf 0 18 separator 0.41496813 361 362 W4239299455.pdf 0 19 contact 0.3340076 ¶ 362 363 W4239299455.pdf 0 20 separator 0.4402016 365 366 W4239299455.pdf 0 21 contact 0.26817238 ¶ 366 367 W4239299455.pdf 0 22 separator 0.63516194 "¶ ¶ ¶ ¶" 369 391 W4239299455.pdf 0 23 title 0.575519 Working Paper Series 391 412 W4239299455.pdf 0 24 paratext 0.7945697 ¶ Volume 1997 (1) 414 432 W4239299455.pdf 0 25 separator 0.67670584 ¶ 433 435 W4239299455.pdf 0 26 paratext 0.52726007 "¶ ¶ ¶" 437 451 W4239299455.pdf 0 27 contact 0.3734892 453 454 W4239299455.pdf 0 28 paratext 0.55062735 ¶ 454 455 W4239299455.pdf 0 29 contact 0.46117297 457 458 W4239299455.pdf 0 30 paratext 0.361558 ¶ 458 459 W4239299455.pdf 0 31 contact 0.9149061 "¶ 350 Victoria Street Toronto, Ontario, M5B 2K3 Tel: (416) 979-5000, x 6739 / Fax: (416) 979-5124 cvss@ryerson. ca" 461 587 W4239299455.pdf 0 32 paratext 0.7604747 ¶ http://www.ryerson.ca/cvss/working_papers / 589 636 W4239299455.pdf 0 33 separator 0.93927157 ¶ ¶ 637 643 W4239299455.pdf 0 0 text 0.9993725 "ARC of 23 mitochondrial genes (adjusted to the ARC across the entire mtDNA) were determined and 78%, 83%, and 87% of these genes were not statistically different from the ARC of wild-type B for MSC3, MSC12, and MSC16, respectively (Table 1). However MSC3had signi ficant ( P,0.05) under-representation of the polycistronic region carrying nad5ex4-atp4-nad5ex5 , which codes for exons 4 and 5 of NADH dehydrogenase subunit 5 and ATPase subunit 4 (Table 1). Inaddition, MSC3 had an over-representation of the cytochrome c bio-genesis FC ( ccmFc ), 18S ribosomal RNA ( rrnS), and ribosomal protein S10 ( rps10 )( T a b l e1 )( P,0.05). MSC12 and MSC16 have an under- representation of ribosomal protein S7 ( rps7)a sc o m p a r e dt ow i l d - t y p e B( T a b l e1 )( P,0.05). In addition, MSC12 ha s under-representation of the 5S ribosomal RNA ( rrn5)( T a b l e1 )( P,0.05), as well as more coverage depth of NADH dehydrogenase subunit 9 ( nad9 ) and ATPse subunit 8 ( atp8). MSC16 had over-representation of ccmFc andrps10 (Table 1) ( P,0.05)." 0 1068 W2149469992.pdf 5 1 separator 0.99681044 ¶ 1068 1070 W2149469992.pdf 5 2 title 0.9766858 "Quantitative PCR con firmed copy number differences among MSC lines and wild-type B" 1070 1155 W2149469992.pdf 5 3 separator 0.987443 ¶ 1155 1157 W2149469992.pdf 5 4 text 0.9995764 "We focused on mitochondrial ge nes that appeared in lower copy number in MSC3, MSC12, and MSC16 relative to wild-type B (Table 1 and Table S1 ). The polycistronic region nad5ex4-atp4-nad5ex5 in MSC3 and rps7 in MSC12 and MSC16 were hypothesized to be likely candidates for their respective M SC phenotypes and their relative amounts were assessed using quantitative (q) PCR (Figure 2 and Table S1). Normalization was performed using the nuclear gene gadph ,b e - cause it has been previously validated as an appropriate reference genefor leaf tissues (Hruz et al. 2011), and we did not detect copy number differences among the MSC lines and wild-type B ( Table S2 )." 1157 1840 W2149469992.pdf 5 5 separator 0.9482322 ¶ 1840 1842 W2149469992.pdf 5 6 text 0.99904895 "Copy numbers of mitochondrial genes were similar for MSC3 and wild-type B except for signi ficantly ( P,0.05) fewer copies of nad5ex4 andatp4 (0.3660.11X and 0.43 60.04X, respectively) and higher copy number of cob(1.2960.05X, apocytochrome b) (Figure 2 and Table S2 )." 1842 2119 W2149469992.pdf 5 7 separator 0.7840297 ¶ 2119 2121 W2149469992.pdf 5 8 text 0.99925274 "Cobdid not show a difference in sequence coverage depth as compared to the wild-type, but did so using qPCR ( Table S2 ). As expected from the next-generation sequencing results, rps7 had sig- nificantly lower copy number at 0.12 60.04X for both MSC12 and 16 relative to B (Figure 2 and Table S2 ). Interestingly, MSC12 and MSC16 had an average of two-fold increased copy number for somemitochondrial genes (up to 2.9-fold) relative to wild-type B (Figure 2 andTable S2 )." 2121 2605 W2149469992.pdf 5 9 separator 0.99402475 ¶ 2605 2607 W2149469992.pdf 5 10 title 0.92393 "Mitochondrial genes in under-represented regions have fewer transcripts compared to wild-type B" 2607 2705 W2149469992.pdf 5 11 separator 0.9775772 ¶ 2705 2707 W2149469992.pdf 5 12 text 0.9992735 "No signi ficant differences were observed for the nuclear transcripts porin andubqc between wild-type B and the MSC lines (Figure 3). As expected, expression of alternative oxidase ( aox)w a ss i g n i ficantly higher in the MSC lines relative to B; AOX is nuclear-encoded protein andshows upregulation in stressed plants and mitochondrial mutants(Karpova et al. 2002, Juszczuk et al. 2007, Polidoros et al. 2009). MSC3 showed lower transcript abundance for nad5ex4 (0.1460.02X) and atp4 (0.4760.07X) as compared to wild-type B (Figure 4). MSC12 and MSC16 had eight-fold fewer transcripts for rps7 as compared to wild- type B (Figure 4 and Table S3 ). In addition, MSC12 had lower (0.5 6 0.12X) expression levels for rrnS (18S rRNA) ( Table S3 ). Surprisingly, all three MSC lines had signi ficantly higher ( P,0.05) expression levels fornad9 ,nad6 ,nad3 ,sdh3,ccmFc ,cob,ccmB ,cox1,atp1,rps3,rpl2, rps13 ,rpl5,a n d rps10 as compared to wild-type B ( Table S3 ). These results suggest that the genetic basis of the mosaic phenotype of MSC3 may be lower amounts of the NAD5 andATP4 proteins, potentially resulting in unstable complexes for NADH dehydrogenase (Complex I)and ATP synthase (Complex V). In the case of MSC12 and MSC16,both may have compromised function of the small subunit in the mitochondrial ribosome due to lower abundance of the RPS7 protein." 2707 4095 W2149469992.pdf 5 13 separator 0.9941821 ¶ 4095 4097 W2149469992.pdf 5 14 title 0.68352985 Liquid chromatography-mass spectrometry 4097 4138 W2149469992.pdf 5 15 text 0.50048923 reveal 4138 4144 W2149469992.pdf 5 16 title 0.6197958 s 4144 4145 W2149469992.pdf 5 17 text 0.5312044 ¶ no 4145 4150 W2149469992.pdf 5 18 title 0.5680811 signi fica 4150 4160 W2149469992.pdf 5 19 text 0.64454067 nt differences in protein 4160 4185 W2149469992.pdf 5 20 title 0.55668515 4185 4186 W2149469992.pdf 5 21 text 0.6078645 "quantity for mitochondrially" 4186 4216 W2149469992.pdf 5 22 title 0.5364853 en 4216 4219 W2149469992.pdf 5 23 text 0.6395609 coded proteins but does fornuclear-encoded mitochondrially targeted proteins 4219 4295 W2149469992.pdf 5 24 separator 0.9765388 ¶ 4295 4297 W2149469992.pdf 5 25 text 0.9991344 "Mitochondrial protein extracts f rom wild-type B, MSC3, MSC12, and MSC16 were evaluated by LC-MS to estimate their relative amounts. A total of 483 proteins were con fidently identi fied, including mitochon- drially encoded ATP1 ,ATP4 ,ATP8 ,NAD7 ,a n d NAD9 (Table 2)." 4297 4571 W2149469992.pdf 5 26 separator 0.9610856 ¶ 4571 4573 W2149469992.pdf 5 27 text 0.9994264 "A m o u n t so fm o s to ft h e s ep r o t e i n sw e r e not statistically different except NAD7 ,w h i c hw a ss i g n i ficantly ( P,0.05) lower in MSC3 and MSC12 as compared to wild-type B. FTSH4 , a nuclear-encoded ATP-dependent mitochondrial protease, had signi ficantly ( P,0.05) higher amounts in MSC16 (Table 2)." 4573 4901 W2149469992.pdf 5 28 separator 0.9871157 ¶ 4901 4903 W2149469992.pdf 5 29 caption 0.9953673 "Figure 2 Fold-change differences with standard errors for copy number of mitochondrial genes among wild-type line B and MSC lines. Normal-ization was performed using the nuclear genegadph as compared to wild-type B as described by Livak and Schmittgen (2001). Signi ficant dif- ference between an MSC mutant for a given mi-tochondrial gene as compared to wild-type Bwas established at a= 0.05 using pairwise t-test." 4903 5326 W2149469992.pdf 5 30 separator 0.9887358 ¶ 5326 5328 W2149469992.pdf 5 31 caption 0.99389374 "Lower and higher copy number comparison be- tween an MSC mutant and wild-type line B areshown as “a”and “b,”respectively." 5328 5452 W2149469992.pdf 5 32 separator 0.97051966 ¶ 5452 5454 W2149469992.pdf 5 33 paratext 0.9880028 1216 | A. R. Del Valle-Echevarria et al.Downloaded from https://academic.oup.com/g3journal/article/5/6/1211/6025283 by guest on 18 May 2024 5454 5594 W2149469992.pdf 5 34 separator 0.99241865 ¶ 5594 5596 W2149469992.pdf 5 0 paratext 0.9885898 Biology 2023 ,12, 1483 16 of 16 0 31 W4389274364.pdf 15 1 separator 0.9929378 ¶ 31 33 W4389274364.pdf 15 2 bibliography 0.99792093 "59. Qanbari, S.; Pausch, H.; Jansen, S.; Somel, M.; Strom, T.M.; Fries, R.; Nielsen, R.; Simianer, H. Classic Selective Sweeps Revealed by Massive Sequencing in Cattle. PLOS Genet. 2014 ,10, e1004148. [CrossRef] [PubMed]" 33 256 W4389274364.pdf 15 3 separator 0.97447777 ¶ 256 258 W4389274364.pdf 15 4 bibliography 0.99783134 "60. Vanvanhossou, S.F.U.; Yin, T.; Scheper, C.; Fries, R.; Dossa, L.H.; König, S. Unraveling Admixture, Inbreeding, and Recent Selection Signatures in West African Indigenous Cattle Populations in Benin. Front. Genet. 2021 ,12, 657282. [CrossRef]" 258 507 W4389274364.pdf 15 5 separator 0.96089303 ¶ 507 509 W4389274364.pdf 15 6 bibliography 0.9980203 61. Guo, H.J.; Tadi, P . Biochemistry, Ubiquitination ; StatPearls Publishing: Treasure Island, FL, USA, 2022. 509 620 W4389274364.pdf 15 7 separator 0.942801 ¶ 620 622 W4389274364.pdf 15 8 bibliography 0.99778455 "62. Myung, J.; Kim, K.B.; Crews, C.M. The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors. Med. Res. Rev. 2001 ,21, 245–273. [CrossRef]" 622 767 W4389274364.pdf 15 9 separator 0.98035103 ¶ 767 769 W4389274364.pdf 15 10 bibliography 0.9970418 "63. Saravanan, K.A.; Panigrahi, M.; Kumar, H.; Parida, S.; Bhushan, B.; Gaur, G.K.; Dutt, T.; Mishra, B.P .; Singh, R.K. Genomic Scans for Selection Signatures Revealed Candidate Genes for Adaptation and Production Traits in a Variety of Cattle Breeds. Genomics 2021 ,113, 955–963. [CrossRef]" 769 1066 W4389274364.pdf 15 11 separator 0.977278 ¶ 1066 1068 W4389274364.pdf 15 12 bibliography 0.9979911 64. Singh, A.; Kumar, A.; Gondro, C.; Da Silva Romero, A.R.; Karthikeyan, A.; Mehrotra, A.; Pandey, A.K.; Dutt, T.; Mishra, B.P . 1068 1198 W4389274364.pdf 15 13 separator 0.961713 ¶ 1198 1200 W4389274364.pdf 15 14 bibliography 0.97975856 "Identification of Genes Affecting Milk Fat and Fatty Acid Composition in Vrindavani Crossbred Cattle Using 50 K SNP-Chip. Trop. Anim. Health Prod. 2021 ,53, 347. [CrossRef]" 1200 1374 W4389274364.pdf 15 15 separator 0.9940729 ¶ 1374 1376 W4389274364.pdf 15 16 text 0.55403644 Disclaimer 1376 1387 W4389274364.pdf 15 17 title 0.48572046 / 1387 1388 W4389274364.pdf 15 18 text 0.5479447 Publisher 1388 1397 W4389274364.pdf 15 19 title 0.48923302 ’s 1397 1399 W4389274364.pdf 15 20 text 0.8972749 "Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content." 1399 1750 W4389274364.pdf 15 0 paratext 0.969575 "3 Scientific RepoRts | (2019) 9:3672 | https://doi.org/10.1038/s41598-019-39605-4 www.nature.com/scientificreports www.nature.com/scientificreports/" 0 162 W2920341818.pdf 2 1 text 0.99744695 "carbon region of the Raman spectra remains unchanged even after prolonged deposition of WS2, indicating that the coating does not interact strongly with the nanotubes. At a sputter time of 20 min, we observe a small broad peak at approximately 800 cm−1, which gradually intensifies until two distinct peaks at 704.1 cm−1 and 804.9 cm−1 emerge at 30 min sputter time. Both peaks are matched to the W-O stretching modes in tungsten (VI) oxide27." 162 614 W2920341818.pdf 2 2 separator 0.54843915 ¶ 615 617 W2920341818.pdf 2 3 text 0.9991579 "A shoulder at approximately 300 cm−1 can also be observed in the Raman spectra at 20 min. With increasing deposition times, this feature transforms into a definite peak at 263.1 cm−1 and another weak shoulder appears at 325.9 cm−1. Both bands correspond to the O-W-O bending modes of WO327. This trend suggests that the partic- ulate film formed during initial deposition is composed of amorphous WO3 that then re-crystallizes with longer sputter times. There appears to be no contribution whatsoever from WS2 regardless of sputtering duration, which is curious as the TEM images depict the distinctive crystalline 2D flakes of WS2. We attribute this to the fact that first, WO3 signals are overwhelming due to the much higher concentration of the WO3 interface/support layer as compared with the 2D WS2 petals that extends from the surface. It is further noted the WO3 peaks at 330 cm−1 slightly overlaps and easily mask the much weaker WS2 Raman peaks at 350 cm−1 leading to this shadowing effect which resulted in the non-detection of the characteristic Raman modes of WS2." 617 1722 W2920341818.pdf 2 4 separator 0.99083734 ¶ 1722 1724 W2920341818.pdf 2 5 caption 0.9955571 "Figure 1. Top view SEM images of (a) pristine CNTs and WS2-CNT samples fabricated at sputter deposition times of (b) 10 min, (c) 20 min, (d) 25 min, (e) 30 min, (f) 35 min, (g) 40 min and (h) 60 min." 1724 1927 W2920341818.pdf 2 0 paratext 0.97639227 Molecules 1998 , 3, M88 0 24 W2036875872.pdf 0 1 separator 0.919732 ¶ 25 27 W2036875872.pdf 0 2 title 0.81596696 2-a, 3-b-Dihydroxyolean-12-en-28-oic Acid (Maslinic Acid) 27 85 W2036875872.pdf 0 3 separator 0.9908414 ¶ 86 88 W2036875872.pdf 0 4 contact 0.97626317 Andres Garcia-Granados*, Antonio Martinez, Juan /glyph1197. Moliz, Andres Parra and Franci sco Rivas 88 189 W2036875872.pdf 0 5 separator 0.58011436 ¶ 190 192 W2036875872.pdf 0 6 contact 0.97832704 "Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Granada , 18071 Granada, Spain. Tel and Fax 34-58-243364, E-mail: agarcia@goliat.ugr.es" 192 357 W2036875872.pdf 0 7 separator 0.9236404 ¶ 358 360 W2036875872.pdf 0 8 paratext 0.9763257 Received: 20 May1998 / Published: 25 July 1998 360 407 W2036875872.pdf 0 9 separator 0.97123003 ¶ ¶ 408 414 W2036875872.pdf 0 10 text 0.997454 "An industrial procedure has been established for the isolation of 2-alpha,3-beta -dihydroxyolean- 12-en- 28-oic acid (maslinic acid) starting from olive fruits ( Olea europaea ). Maslinic acid [4373-41-5] has been identified by its physical constants and spectroscopical data (See refe rences). It is affordable on a large scale in two qualities: Solid white powder (85% content, 15% other terpene compounds) or c hemically pure maslinic acid ( >97%)." 414 878 W2036875872.pdf 0 11 separator 0.98245776 ¶ 879 881 W2036875872.pdf 0 12 text 0.768941 "1H NMR of the methylester of this product (solvent CDCl 3): 0.70 (3H-26), 0.80 (3H-24), 0.88 (3H-29), 0.90 (3H-30), 0.96 (3H-25), 1.01(3H-23), 1.11 (3H-27), 5.05 (1H-12), 3.45 (1H-2), 2.75 (1H-3), 2.6 (1H-18)." 881 1097 W2036875872.pdf 0 13 separator 0.8023845 ¶ 1098 1100 W2036875872.pdf 0 14 text 0.7893168 "13 C NMR of the methylester of this product (solvent CDCl 3): 46.12 (C1), 68.24 (C2), 83.17(C3), 38.97(C4)," 1100 1211 W2036875872.pdf 0 15 table 0.4864436 5 1211 1213 W2036875872.pdf 0 16 text 0.5527405 5.05 (C5), 1213 1223 W2036875872.pdf 0 17 table 0.47331864 18.5 1223 1228 W2036875872.pdf 0 18 text 0.5413459 2 (C6) 1228 1234 W2036875872.pdf 0 19 table 0.4974949 , 32.29 ( 1234 1244 W2036875872.pdf 0 20 text 0.5553676 C7) 1244 1247 W2036875872.pdf 0 21 table 0.5321233 , 39.07 ( 1247 1256 W2036875872.pdf 0 22 text 0.5023988 C8), 1256 1260 W2036875872.pdf 0 23 table 0.62310755 47 1260 1263 W2036875872.pdf 0 24 text 0.4915491 .38 1263 1266 W2036875872.pdf 0 25 table 0.47074753 ( 1266 1268 W2036875872.pdf 0 26 text 0.5337928 C9), 1268 1272 W2036875872.pdf 0 27 table 0.6807387 37. 1272 1276 W2036875872.pdf 0 28 text 0.5244193 88 (C10), 1276 1285 W2036875872.pdf 0 29 table 0.5379782 23.18 1285 1291 W2036875872.pdf 0 30 text 0.5213632 (C11), 1291 1298 W2036875872.pdf 0 31 table 0.5246426 121.86 1298 1305 W2036875872.pdf 0 32 text 0.5234865 ¶ 1306 1308 W2036875872.pdf 0 33 table 0.50161266 (C12), 143.71 (C 1308 1325 W2036875872.pdf 0 34 text 0.45082995 13) 1325 1328 W2036875872.pdf 0 35 table 0.58337426 ", 41.52 (C14), 27.37 (C15), 22.73 (C16), 46.12 (C17), 41.00 (C18), 45.71 (C19), 30.36 (C20), 33.60 (C21), 32.39 (C22), 28.21 (C23), 16.14 (C24), 16.37 (C25), 16.54 (C26), 27.37 (C27)" 1328 1513 W2036875872.pdf 0 36 text 0.44932535 , ¶ 1513 1517 W2036875872.pdf 0 37 table 0.5226751 180.58,( 1517 1526 W2036875872.pdf 0 38 text 0.4353813 C 1526 1527 W2036875872.pdf 0 39 table 0.4756844 28) 1527 1530 W2036875872.pdf 0 40 text 0.4971003 , 1530 1531 W2036875872.pdf 0 41 table 0.5304297 32.67 1531 1537 W2036875872.pdf 0 42 text 0.48330644 (C 1537 1540 W2036875872.pdf 0 43 table 0.4907083 29) 1540 1543 W2036875872.pdf 0 44 text 0.50916344 , 1543 1544 W2036875872.pdf 0 45 table 0.46374828 23.14( 1544 1551 W2036875872.pdf 0 46 text 0.5390857 Me). 1551 1555 W2036875872.pdf 0 47 separator 0.99418473 ¶ 1556 1558 W2036875872.pdf 0 48 title 0.8976579 References 1558 1569 W2036875872.pdf 0 49 separator 0.9878862 ¶ 1570 1572 W2036875872.pdf 0 50 bibliography 0.97998977 "1. Dictionary of /glyph817atural Products on CD-ROM , Chapman and Hall, London, 1997. ISSN 0966-2146 2. Visit the http://probe.nalusda.gov:8300/cgi-bin/browse/phytochemdb websit e." 1572 1756 W2036875872.pdf 0 51 separator 0.9218915 ¶ 1757 1759 W2036875872.pdf 0 52 bibliography 0.92671335 Sample availability: Commercially available from the authors. MDPI Reg. No. 15849 . 1759 1844 W2036875872.pdf 0 53 separator 0.8584132 ¶ 1844 1846 W2036875872.pdf 0 54 paratext 0.98241967 ©1998 MDPI. All rights reserved. Molecules website http://www.mdpi.org/molecules/ M0088 http://www.mdpi.org/molbank/m0088.htm 1846 1973 W2036875872.pdf 0 55 separator 0.7920022 ¶ 1974 1976 W2036875872.pdf 0 56 paratext 0.9819421 1 von 1 07.05.2009 13:58 1976 2001 W2036875872.pdf 0 57 separator 0.99548537 ¶ 2002 2004 W2036875872.pdf 0 0 text 0.99969995 "the liver ( 1,2) ;T h em u l t i p l ei n t r a h e p a t i cl e s i o n sw i t hm o r es e v e r e destruction of intrahepatic structures have led to a relatively small number of patients, only 35%, undergoing radical hepatectomy (3,4), Liver transplantation was recognized as the best treatment for patients with advanced hepatic alveolar echinococcosis because of the destruction of the liver and surrounding organs and the redu ced prognosis for patients with such advanced disease ( 5). However, allogeneic liver transplantation can be associated with a shortage of donor ’s livers during treatment, and lifelong immunosuppressive medication, which leads to a signi ficantly higher risk of recurrence of encapsulated worms and affects the use of liver transplantation in HAE ( 5,6). Pichlmayr ’st e a m( 7)first completed the resection of hepatic malignancies in 1988 usingELRA as a radical approach for tumours that conventional surgery could not remove. To overcome the dilemma faced by liver transplantation in HAE, in 2011, Professor Wen Hao ’s team ( 8)first reported the application of the isolated liver resection technique combined with ELRA to the treatment of HAE patients, which several cen tres subsequently adopted in China for the treatment of HAE with good results. The clinical data and follow-up data of 13 ELRA patients admitted to the Affiliated Hospital of Qinghai University from January 2015 to December 1, 2020, are retrospectively analyzed and reported." 0 1522 W4320920011.pdf 1 1 separator 0.98898536 ¶ 1522 1524 W4320920011.pdf 1 2 title 0.98870766 Patients and methods 1524 1545 W4320920011.pdf 1 3 separator 0.9935935 ¶ 1545 1547 W4320920011.pdf 1 4 text 0.9996656 "Data of patients undergoing surgery: The data of 13 patients admitted to the Af filiated Hospital of Qinghai University from January 2015 to January 2020 who underwent ELRA for advanced hepatic vesicular encrustation disease were retrospectively analyzed, and the ir main characteristics were as follows: (1) the target lesion was challenging to resect in vivo , the reserved hepatic involved vasculature was dif ficult to resect and reconstruct, and bleeding from the liver and blood vessels close to the liver was dif ficult to control; (2) the prepared left hepatic vein-inferior vena cava venous con flu e n c es i t ei n v a s i o n , pre-existing hepatic portal vein tertiary and higher branch invasion; (3) patient in the good physical condition and normal liver and renal function before surgery. There were 3 cases (23.1%) of males and 10 (76.9%) of females, aged 18 –59 years, with a mean age of 38.3 years. Patients presented with symptoms of jaundice before surgery in 8 cases; recurrent upper abdominal discomfort in 5 cases; Indocyanine green retention rate at 15 min <10% in 6 cases and >10% in 7 cases; Child-Pugh A in 8 cases and grade B in 5 cases; all patients underwent preoperative PHI staging (HX-PHI Staging system) ( 9), The severity of vascular erosion was classi fied into 3 grades and different types according to the preoperative imaging assessment of the operated patients; the speci fic typing and grading levels are shown in Table 1 . this study complied with the Declaration of Helsinki. All patients had postoperative pathology con firmed as hepatic echinococcosis; the patients and their families signed an informed consent form. The patient ’sp r e o p e r a t i v ec l i n i c a l data and preoperative assessment results are shown in Table 2 ." 1547 3375 W4320920011.pdf 1 5 title 0.9871558 Preoperative surgical feasibility assessment 3375 3419 W4320920011.pdf 1 6 separator 0.99268043 ¶ 3419 3421 W4320920011.pdf 1 7 text 0.99971235 "Imaging was performed to understand the size, extent of infiltration,vascular and biliary involvement of the liver lesion ( 10, 11)(Figure 1A ); for patients with extensive invasion and/or compression of the posterior hepatic inferior vena cava, an inferior vena cava angiogram was required; the degree of inferior vena cava stenosis was assessed and the presence or absence of collateral circulation established ( Figure 1B ); all patients were treated with three-dimensional reconstruction of the liver and a liver model was created ( Figure 1C ) to visualize the size of the lesion, calculate the actual liver volume, liver lesion volume, remaining liver volume,and standard liver volume to assess the surgical outcome to ensure the safety of the procedure ( 12,13); the ICGR 15-minute retention rate was performed 1 week before surgery in all patients to assess the reserve function of the patient ’s liver to predict the occurrence of liver failure after surgery; all patients were treated preoperatively according to semi-ex Vivo All patients were prepared preoperatively for hepatectomy or hepatectomy combined with autologous transplantation." 3421 4603 W4320920011.pdf 1 8 separator 0.996295 ¶ 4603 4605 W4320920011.pdf 1 9 title 0.9914388 Surgical procedures 4605 4625 W4320920011.pdf 1 10 separator 0.99299777 ¶ 4625 4627 W4320920011.pdf 1 11 text 0.9997352 "After general anaesthesia, an incision is made through a herringbone incision, layer by layer, until the abdominal cavity is entered. Once the lesion is seen, intraoperative ultrasonography is used to demonstrate the intrahepatic invasion of the lesion further, to make a preliminary determination of the status of the lesion to the hilar, and to examine other extrahepatic organs for the presence of extrahepatic metastases. Adequate freeing of the liver, with the the third porta hepatis (at the lower part of the vena cava sulcus, at the outlet of the right posterior inferior hepatic vein and caudate vein) as utterly free as possible or, if the the third porta hepatis is found to be invaded by a lesion, in vitro separation after adequate dissection; sequential blocking and dissection of the CHD (common hepatic duct), PHA (Proper hepatic artery), SHIVC (suprahepatic inferior vena cava), IHIVC (Inferhepatic inferior vena cava) RHIVC (Retrohepatic inferior vena cava) from the body (Figure 1D ). The inferior vena cava was reconstructed by end-to- end anastomosis of the arti ficial vessel-superior and inferior vena cava using a 6-0 prolene wire ( Figure 1E ). A temporary portal vein shunt was established by end-to-end anastomosis of the PV to the artificial IVC. These two routine steps maintain hemodynamic stability during the procedure. Blood gas analysis, including pH, LAC, and SaPO2, was performed at 1-hour intervals, and anaesthetic adjustments were made accordingly. After the liver is removed from the body, the liver is continuously lavaged with 0-4° lavage solution viathe portal vein, followed by sequential lavage of the hepatic artery and the intra- and extrahepatic bile ducts. The ultrasonic knife and bipolar electrocoagulation forceps were used to separate the liver parenchyma along the hepatic sickle ligament and carefully isolate the liver lesion, followed by complete resection of the diseased liver ( Figure 1F ), the healthy side intact. After the reserved liver has been repaired ex vivo ( Figure 1I ), the reconstructed hepatic vein is lateralized to the arti ficial inferior" 4627 6802 W4320920011.pdf 1 12 paratext 0.5127689 Yuan 6802 6806 W4320920011.pdf 1 13 text 0.5568412 et 6806 6809 W4320920011.pdf 1 14 paratext 0.91613144 al. 10.3389/fsurg.2023.1089788 6809 6840 W4320920011.pdf 1 15 separator 0.6253037 ¶ 6840 6842 W4320920011.pdf 1 16 paratext 0.981277 Frontiers in Surgery 02 frontiersin.org 6842 6882 W4320920011.pdf 1 0 caption 0.7918365 Figure 4 0 8 W4286638093.pdf 22 1 separator 0.99590576 ¶ 8 10 W4286638093.pdf 22 2 caption 0.6971019 Gene duplication analysis of GhPRXs . 10 48 W4286638093.pdf 22 3 separator 0.9842063 ¶ 48 50 W4286638093.pdf 22 4 caption 0.91053486 (A) paralogous gene pairs among G.hirumtum . (B) Ka, Ks, Ka/Ks distribution of PRXs gene 50 140 W4286638093.pdf 22 5 separator 0.87047493 ¶ 140 142 W4286638093.pdf 22 6 caption 0.77074087 pairs. Ka, Ks, Ka/Ks analysis of GhPRXs -GhPRXs . 142 192 W4286638093.pdf 22 7 separator 0.994521 ¶ 192 194 W4286638093.pdf 22 8 paratext 0.9806444 PeerJ reviewing PDF | (2021:12:69244:2:0:NEW 19 May 2022) 194 252 W4286638093.pdf 22 9 separator 0.9902302 ¶ 252 254 W4286638093.pdf 22 10 paratext 0.80473304 Manuscripttobereviewed 254 277 W4286638093.pdf 22 0 paratext 0.9744112 "Veterinary World, EISSN: 2231-0916 Available at www.veterinaryworld.org/Vol.8/April-2015/17.pdf Veterinary World, EISSN: 2231-0916 523RESEARCH ARTICLE Open Access" 0 168 W2003954981.pdf 0 1 separator 0.9374888 ¶ 168 170 W2003954981.pdf 0 2 title 0.9704145 "Utility of a rapid immunochromatographic strip test in detecting canine parvovirus infection compared with polymerase chain reaction" 170 306 W2003954981.pdf 0 3 separator 0.98884964 ¶ 306 308 W2003954981.pdf 0 4 contact 0.988933 "Sundaran S. Tinky, R. Ambily, Sreeja R. Nair and Mangattumuruppel Mini Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Mannuthy, Thrissur, Kerala Corresponding author: R. Ambily, e-mail: ambilysd@gmail.com, SST: ss4tinky@gmail.com, SRN: drsreejarnair@gmail.com, MM: mini@kvasu.ac.in" 308 686 W2003954981.pdf 0 5 separator 0.8688972 ¶ 686 688 W2003954981.pdf 0 6 paratext 0.9613377 "Received: 18-12-2014, Revised: 19-03-2015, Accepted: 26-03-2015, Published online: 21-04-2015 doi: 10.14202/vetworld.2015.523-526. How to cite this article: Tinky SS, Ambily R, Nair SR, Mini M. (2015) Utility of a rapid immunochromatographic strip test in detecting canine parvovirus infection compared with polymerase chain reaction, Veterinary World 8(4); 523-526." 688 1067 W2003954981.pdf 0 7 separator 0.99395156 ¶ 1067 1069 W2003954981.pdf 0 8 title 0.9247947 Abstract 1069 1078 W2003954981.pdf 0 9 separator 0.9931598 ¶ 1078 1080 W2003954981.pdf 0 10 text 0.9981302 "Aim: The present study was undertaken to detect the presence of canine parvovirus (CPV) in fecal samples of diarrheic dogs by conventional polymerase chain reaction (PCR) and immunochromatographic (IC) strip test and to compare the diagnostic potential of these tests." 1080 1353 W2003954981.pdf 0 11 separator 0.8870378 ¶ 1353 1355 W2003954981.pdf 0 12 text 0.99904156 "Materials and Methods: A total of 50 fecal samples collected from diarrheic dogs suspected for CPV infection were subjected to PCR using CPV-555 primer amplifying the gene coding for the VP1 protein. These samples were also tested by IC strip test using a commercial rapid Ag test kit. The results were statistically analyzed using McNemar test." 1355 1705 W2003954981.pdf 0 13 separator 0.89563215 ¶ 1705 1707 W2003954981.pdf 0 14 text 0.99959534 "Results: A total of 22 samples (44%) were detected as positive by PCR, which yielded a specific amplicon of 583 bp. In IC strip test, 18 (36%) samples were found to be positive. The sensitivity of the test as compared to PCR was found to be 72.22% and specificity was 92.86%. Positive predictive value and negative predictive value of IC strip test was found to be 88.89% and 81.25%, respectively. Statistical analysis of the results of PCR and IC assay using McNemar test revealed no significant difference (p>0.05)." 1707 2229 W2003954981.pdf 0 15 separator 0.72487867 ¶ 2229 2231 W2003954981.pdf 0 16 text 0.9976105 "Conclusion: The IC strip test could be employed as a rapid field level diagnostic tool for the diagnosis of canine parvoviral diarrhea." 2231 2371 W2003954981.pdf 0 17 separator 0.9364535 ¶ 2371 2373 W2003954981.pdf 0 18 text 0.97762066 Keywords: canine parvoviral diarrhea, immunochromatographic strip test, polymerase chain reaction. 2373 2473 W2003954981.pdf 0 19 separator 0.9962001 ¶ 2473 2475 W2003954981.pdf 0 20 title 0.926261 Introduction 2475 2488 W2003954981.pdf 0 21 separator 0.9944117 ¶ 2488 2490 W2003954981.pdf 0 22 text 0.99955636 "Parvoviral enteritis is a highly contagious disease causing heavy mortality in dogs all over the world. Early and rapid diagnosis is quintessential, so that the infected dogs can be isolated and supportive treatment can be adopted to reduce morbidity and mortality [1]. The etiological agent is canine parvovirus (CPV), which emerged in the 1970s as a host range variant of feline panleukopenia virus (FPV). The virus is now classified as Carnivore protoparvovirus 1 [2]. The infection is characterized by acute hemorrhagic gas-troenteritis in adult dogs and myocarditis in puppies causing high morbidity and mortality [3]." 2490 3117 W2003954981.pdf 0 23 separator 0.9128626 ¶ 3117 3119 W2003954981.pdf 0 24 text 0.999669 "Diagnosis on the basis of clinical signs is not definitive, since several other pathogenic organisms can cause diarrhea in dogs. Therefore, a clinical diag-nosis should always be confirmed with laboratory tests. The standard method for the identification of CPV infection is the detection of morphologically intact virus particles by electron microscopy (EM). This method is fast and specific, but expensive and less sensitive [4]. Isolation of the virus from sus-pected fecal samples is laborious and time consuming [5]. Thus, although EM and virus isolation are highly specific, they are not often used routinely in a clinical setting [6]. Hemagglutination test seems to be accept-able in routine diagnosis because the test is relatively simple, rapid, and inexpensive, but it is less sensitive and specific [7]. Serological tests fail to diagnose infections in acute stages. Hence, early diagnosis is focused on molecular methods such as polymerase chain reaction (PCR). It is a reliable technique with high degree of sensitivity and specificity in detecting CPV from fecal samples than the conventional anti-gen or antibody based methods [8,9]. However, the technique needs relatively expensive equipment and reagents, which are not available in routine veterinary practice. This has led to the development of various rapid field level diagnostic test kits based on the prin-ciple of immunochromatography [10]. The advantage is that these tests are easy to perform with minimal costs even by the dog owners [11]." 3119 4642 W2003954981.pdf 0 25 separator 0.90678406 ¶ 4642 4644 W2003954981.pdf 0 26 text 0.99938345 "However, the efficacies of these rapid tests are often dubious. Considering the above facts, it was decided to detect CPV among diarrheic dogs by PCR and immunochromatographic (IC) strip test and to compare the diagnostic potential of these tests." 4644 4895 W2003954981.pdf 0 27 separator 0.99705845 ¶ 4895 4897 W2003954981.pdf 0 28 title 0.9886404 Materials and Methods 4897 4919 W2003954981.pdf 0 29 separator 0.99484724 ¶ 4919 4921 W2003954981.pdf 0 30 title 0.98627883 Ethical approval 4921 4938 W2003954981.pdf 0 31 separator 0.993845 ¶ 4938 4940 W2003954981.pdf 0 32 text 0.9973018 "No ethical approval is necessary for clinical cases. However, all samples were collected as per standard sample collection procedure" 4940 5076 W2003954981.pdf 0 33 paratext 0.9533748 ".Copyright: The authors. This article is an open access article licensed under the terms of the Creative Commons Attributin License (http://creative commons.org/licenses/by/2.0) which permits unrestricted use, distribution and reproduction in any medium, provided the work is properly cited." 5076 5370 W2003954981.pdf 0 0 text 0.999705 "configurations with two kinds of boundary conditions. They are ass ociated with the Rindler metric and the Taub one, respectively [ 77–83]. A geometry of these configurations consists in the flat space with the Rindler metric from one side of the slice and wit h the Taub metric from another side. An unexpected peculiarity of the solutions is loos ing of mirror symmetry [77,78]. A slice with a matter is inside a singular surface. Contrary to this, th e solution (24), (25) is regular, naturally preserves mirror symmetry, satisfies all the energy conditions and opens a way to find a full general-relativistic solution for the disk , at least, numerically (see Appendix). We can note that the disk field and the field with the T aub metric are qualitatively different as follows from the second-order invariants." 0 823 W3098079631.pdf 22 1 separator 0.9839282 ¶ 823 825 W3098079631.pdf 22 2 text 0.99974644 "We can certify that the spacetime attributed to the large disk is ess entially curved. At some time, anincrease of the disk radius leaves all thedisk under the horizon. Therefore, the disk radius is limited. As a result, the Riemann tensor and the field inhom ogeneity cannot be vanished. The Ricci tensor is zero. The existence of a horizon at a large disk radius is the main disagreement with the previous results [ 13–20]. Even for the arbitrarily small surface mass density, one can find so large disk radius Rthatrg/R>>1. In this case, the field of the gravitating disk is equivalent to that of a pointlike Schwarz schild source and all points near the disk surface are under the horizon . Therefore, the infinite gravitating plane is a nonexistent object. Importantly, the nonexistence of the un iform gravitational field has been proven without the use of the weak-field approximation . The same result follows from the brane-world point of view, where the infinite plane is embedded in 3 D space." 825 1843 W3098079631.pdf 22 3 separator 0.9877534 ¶ 1843 1845 W3098079631.pdf 22 4 text 0.9996662 "This conclusion is very important for the correct analysis of the EEP . Sec.VIpresents a comparison of the equations of particle motion in the three importan t quasi-uniform gravita- tional fields and in the uniformly accelerated frame. We have conside red the Schwarzschild field in the Cartesian and isotropic coordinates and the field of the gr avitating disk. The equations of particle motion in all four cases do not coincide with each other while the New- tonian limit in these cases is the same. Therefore, the spatial inhomo geneity significantly influences the form of the equations of motion. Since the EEP has be en formulated only relative to a constant uniform gravitational field [ 1], it is not violated by the results pre- sented. Thus, the consideration of the quasi-uniform gravitation al field of the disk confirms the conclusion first made in Ref. [ 4]." 1845 2728 W3098079631.pdf 22 5 separator 0.9400457 ¶ 2728 2730 W3098079631.pdf 22 6 text 0.99953467 "It is also important that the gravitoelectromagnetic fields in the Sch warzschild spacetime in the Cartesian and isotropic coordinates and in the quasi-uniform g ravitational field of the" 2730 2918 W3098079631.pdf 22 7 separator 0.8897934 ¶ 2918 2920 W3098079631.pdf 22 8 paratext 0.75237715 23 2920 2923 W3098079631.pdf 22 0 paratext 0.9848647 1055 0 4 W3112914009.pdf 4 1 separator 0.95102036 ¶ ¶ 6 12 W3112914009.pdf 4 2 title 0.8746196 "Shalsabila Jasmira Aisyah Identify the Protective Effect of Garlic as Antioxidant Against Free Radicals Simpulan Dan Saran" 12 139 W3112914009.pdf 4 3 separator 0.9934182 ¶ 141 143 W3112914009.pdf 4 4 text 0.99858946 "Terbukti bahwa bawang putih yang memiliki khasiat antioksidan lebih adalah bawang putih local siung tunggal dan aged garlic dibandingkan fresh . Zat organosulfur pada bawang putih antara lain flavonoid, adenosin, ahoene, dan alliin . Ketika bawang putih mentah dihancurkan, akan terjadi proses pemecahan sel dari allicin menjadi Allyl tiosulfat yang berperan penting dalam proses pe nurunan lipid, antikanker, dan antio ksidan . Karena penelitian yang telah dibahas dilakukan dengan metode DPPH, maka masih perlu dilakukan penelitian lebih lanjut dengan metode in vivo terutama pada histopatologi berbagai macam organ pada mencit atau tikus dengan dosis bertingkat dimana sumbe r radikal bebas langsung dari paparan asap rokok samping atau side stream smoke ." 143 930 W3112914009.pdf 4 5 separator 0.99559927 ¶ 931 933 W3112914009.pdf 4 6 title 0.9607121 Daftar Rujukan 933 948 W3112914009.pdf 4 7 separator 0.98077923 ¶ 950 952 W3112914009.pdf 4 8 bibliography 0.99710184 "Chairunnisa, O. P. (2019). Literatur Review Efek Bawang Putih ( Allium Sativ um L ) Sebagai Pengobatan Penyakit Ja ntung Koroner . 10(2), 250–254. https://doi.org/10.35816/jiskh.v10i2.160" 952 1148 W3112914009.pdf 4 9 separator 0.97671735 ¶ 1150 1152 W3112914009.pdf 4 10 bibliography 0.9981086 "Febrinda, A., Astawan, M., Wresdiyati, T., & Dewi Yuliana, N. (2013). Kapasitas Antioksidan Dan Inhibitor Alfa Glukosidase Ekstrak Umbi Bawang Daya k. Jurnal Teknologi Dan Industri Pang an, 24(2), 161–167. https://doi.org/10.6066/jtip.2013.24.2.161" 1152 1407 W3112914009.pdf 4 11 separator 0.9782618 ¶ 1409 1411 W3112914009.pdf 4 12 bibliography 0.9979492 "Gruhlke, M. C. H., Nicco, C., Batteux, F., & Slusarenko, A. J. (2017). The effects of allicin, a reactive sulfur species from garlic, on a selection of mamm alian cell lines. Antioxidants , 6(1), 1–16. https://doi.org/10.3390/antiox6010001" 1411 1659 W3112914009.pdf 4 13 separator 0.9595748 ¶ 1661 1663 W3112914009.pdf 4 14 bibliography 0.9967271 "Hendra, H. (2017). Pengaruh Pemberian Ekstrak Bawang Putih (Allium Sativum L.) Dan Lama Penyimpanan Terhadap Daya Awet Tahu Putih . Biota , 3(2), 54. https://doi.org/10.19109/b iota.v3i2.1193" 1663 1861 W3112914009.pdf 4 15 separator 0.97605866 ¶ 1863 1865 W3112914009.pdf 4 16 bibliography 0.99755996 "Jang, H. J., Lee, H. J., Yoon, D. K., Ji, D. S., Kim, J. H., & Lee, C. H. (2018). Antioxidant and antimicrobial activities of fresh garlic and aged garlic by -products extracted with different solvents. Food Science and Biotechnology , 27(1), 219–225. https://doi.org/10.1007/s10 068 -017 -0246 -4" 1865 2173 W3112914009.pdf 4 17 separator 0.9699309 ¶ 2174 2176 W3112914009.pdf 4 18 bibliography 0.9977159 "Ko, J. W., Jeong, S. H., Kwon, H. J., Shin, N. R., Seo, Y. S., Kim, J. C., Shin, I. S., & Kim, J. S. (2018). Preventive effect of garlic oil and its organosulfur component diallyl - disulfide on cigarette sm oke-induced airway inflammation in m ice. Nutrients , 10(11), 1–12. https://doi.org/10.3390/nu10111659" 2176 2495 W3112914009.pdf 4 19 separator 0.9663358 ¶ 2497 2499 W3112914009.pdf 4 20 bibliography 0.99756837 "Lawson, L. D., & Hunsaker, S. M. (2018). Allicin bioavailability and bioequivalence from garlic supplements and garlic foods. In Nutrients (Vol. 10, Issue 7). https://doi.org/10.3390/nu100708 12" 2499 2701 W3112914009.pdf 4 21 separator 0.9824223 ¶ 2702 2704 W3112914009.pdf 4 22 bibliography 0.9973452 "Martaningtyas, D. C., Nurliani, A., & Rusmiati. (2015). Efek Antioksidan Ekstrak Etanol Bulbus Bawang Dayak ( Eleutherine americana ) terhadap Kualitas Spermatozoa Tikus Putih ( Rattus norvegicus L ) yang Dipapar Asap Rokok Kretek. Jsv, 33(1), 85– 93." 2704 2965 W3112914009.pdf 4 23 separator 0.9839113 ¶ 2966 2968 W3112914009.pdf 4 24 bibliography 0.9974924 "Milo, S. (2015). Hubungan Kebiasaan Merokok di Dalam Rumah Dengan Kejadian ISPA Pada Anak Umur 1 -5 Tahun di Puskesmas Sario Kota Manado. EJournal Keperawatan , 3(2), 2–6." 2968 3146 W3112914009.pdf 4 25 separator 0.98806965 ¶ 3147 3149 W3112914009.pdf 4 26 bibliography 0.99497795 "Mohi El -Din, M. M., Mostafa, A. M., & Abd -Elkader, A . (2014). Experimental studies on th e effect of (Lambda -Cyhalothrin) insecticide on lungs and the ameliorating effect of plant extracts (Ginseng (Panax Ginseng) and garlic (Allium sativum L.) on asthma development in albino rats. BMC Research Notes , 7(1), 1–10. https://doi.org/10.1186/1756 -0500 -7-243" 3149 3523 W3112914009.pdf 4 27 separator 0.9847932 ¶ 3525 3527 W3112914009.pdf 4 28 bibliography 0.99780357 "Nurjanah, Kresnowati, L., & Mufid, A. (2014). Gangguan Fungsi Paru Dan Kadar Cotinine Pada Urin Karyawan Yang Terpapar Asap Rokok Orang Lain. Jurnal Kesehatan Masyarakat , 10(1), 43–52. https://doi.org/10.15294/ kemas.v10i1.3069" 3527 3762 W3112914009.pdf 4 0 text 0.9562498 "to the frequency of blog postings at time tby user i. Next, we use the following relation between the execution rate mi(t)and the activity Ai, " 0 147 W2007921612.pdf 5 1 math 0.8010839 "¶ ci T(i) totðT(i) tot 0mi(t)dt~Ai, ð11Þ " 147 196 W2007921612.pdf 5 2 text 0.95680016 "¶ where ciis a proportionality constant. For the arriving rate li(t), since we do not have any information of when a new task isarriving, we assume l i(t)to be the same as mi(t)." 196 378 W2007921612.pdf 5 3 separator 0.9628669 ¶ 378 380 W2007921612.pdf 5 4 text 0.9952333 "Based on this idea, for each user i, we perform numerical simulations as follows:" 380 464 W2007921612.pdf 5 5 separator 0.70256186 ¶ 464 466 W2007921612.pdf 5 6 text 0.99270403 "i) We numerically generate both arrival and execution time sequences ftkg[(0,T(i) tot/C138through the Poisson process with the rates mi(t)andli(t)[31]. ii) Subsequent these time sequences, we input a task into the queue when it is not full of Litasks, where the queue size Lii s determined at a later stage. Upon arrival, the task is given apriority x[1⁄20,1/C138. At the same time, a task with the highest priority is executed and removed from the queue. Thewaiting time of the task is also recorded. iii) We repeat this procedure until N iwaiting times are obtained. Niis regarded as the number of blog posts uploaded by user i." 466 1115 W2007921612.pdf 5 7 separator 0.62186605 ¶ 1115 1117 W2007921612.pdf 5 8 text 0.99635345 "In this model, the activity is determined to be Ai~Ni=T(i) tot, whereas the queue size Liand the proportionality constant ci remain to be determined." 1117 1273 W2007921612.pdf 5 9 separator 0.97895384 ¶ 1273 1275 W2007921612.pdf 5 10 text 0.9992628 "To determine Liandci, i.e., to generate a synthetic probability distribution function fit to the empirical data, we use theKolmogorov-Smirnov (KS) statistical test [32]. We obtain a set of^LL jand ^ccjfor each user iby minimizing the KS statistic between the empirical data and simulated data. They are distributed as shown in Fig. 7. The closeness between the empirical data and thesimulated data is tested (see Fig. 8): the obtained pvalue is shown in the legend. It is known that if the p-value is higher than a preassigned value ( p~0:05), then one can accept the null hypothesis that the probability distribution functions are identical.As we can see in the p-value histogram of Fig. 7(b), most cases show good agreement between synthetic and empirical data withhigh pvalues: The fraction of users is 23.2% for pw0:9, and86.3% for pw0:1. Thus, it can be said that our theoretical result reasonably reproduces the empirical pattern." 1275 2232 W2007921612.pdf 5 11 separator 0.9777639 ¶ 2232 2234 W2007921612.pdf 5 12 text 0.9995236 "Moreover, we simulate the queuing process by using the average rates of SmTand SlTinstead of the time-dependent form ofm(t)andl(t)for each user. In most cases, there is only a slight difference between the two simulated results with different types of parameters as shown in Fig. 8. However, there are apparent different cases for the two results; these occur when periodic time intervals appear in the activity of writing blog posts. In this case, the time-dependent forms m(t)andl(t)are better for fitting to the empirical data." 2234 2781 W2007921612.pdf 5 13 separator 0.9962579 ¶ 2781 2783 W2007921612.pdf 5 14 title 0.9885609 Conclusions 2783 2795 W2007921612.pdf 5 15 separator 0.99586135 ¶ 2795 2797 W2007921612.pdf 5 16 text 0.9956845 "In this work, we have studied the inter-event time statistics of human dynamics based on a large scale of on-line records of blog writings at a Korean portal site. We observed that the IET distributions of each user exhibit a universal pattern in the short- time regime, but they exhibit different decay patterns in the long- time regime, which depends on the activities of individual users. " 2797 3200 W2007921612.pdf 5 17 separator 0.6029604 ¶ 3200 3201 W2007921612.pdf 5 18 text 0.99945486 "Moreover, we observed a clear periodic pattern with a period of one day, which reflects the circadian pattern of human behavior." 3201 3332 W2007921612.pdf 5 19 separator 0.9129202 ¶ 3332 3334 W2007921612.pdf 5 20 text 0.99946755 "We explained these patterns within the framework of the queueing model. First, we identified active and inactive time intervals of individual behaviors and then removed inactive time interval and constructed an ad-hoc time domain. Next, we applied the priority- based queueing model in the ad-hoc time domain by adjusting the arrival and execution rates of tasks to the empirical data. Following this, we returned to the real time domain and found our theoretical results to be in agreement with the empirical results including the positions of circadian peaks [6,13,18,27]. The microscopic studies performed in this paper enable us tounderstand these empirical results from a theoretical perspective." 3334 4054 W2007921612.pdf 5 21 separator 0.9968501 ¶ 4054 4056 W2007921612.pdf 5 22 title 0.94624346 Acknowledgments 4056 4072 W2007921612.pdf 5 23 separator 0.994323 ¶ 4072 4074 W2007921612.pdf 5 24 text 0.87064 "We would like to thank Mr. Youn Sik Lee, Director of Data Information Center, for allowing for using the data after deleting user names, and Mr. Sukwon Kang for helpful discussion." 4074 4259 W2007921612.pdf 5 25 separator 0.9954667 ¶ 4259 4261 W2007921612.pdf 5 26 title 0.91445917 Author Contributions 4261 4282 W2007921612.pdf 5 27 separator 0.9904183 ¶ 4282 4284 W2007921612.pdf 5 28 text 0.9335453 "Conceived and designed the experiments: BK JK. Analyzed the data: JKDL. Contributed reagents/materials/analysis tools: JK. Wrote the paper: BK JK." 4284 4433 W2007921612.pdf 5 29 separator 0.9943073 ¶ 4433 4435 W2007921612.pdf 5 30 title 0.8295336 References 4435 4446 W2007921612.pdf 5 31 separator 0.99177766 ¶ 4446 4448 W2007921612.pdf 5 32 bibliography 0.99802077 "1. Lazer D, Pentland A, Adamic L, Aral S, Baraba ́si AL, et al. (2009) SOCIAL SCIENCE: computational social science. Science 323: 721–723." 4448 4589 W2007921612.pdf 5 33 separator 0.7886697 ¶ 4589 4591 W2007921612.pdf 5 34 bibliography 0.9978643 "2. Castellano C, Fortunato S, Loreto V (2009) Statistical physics of social dynamics. Rev Mod Phys 81: 591646." 4591 4704 W2007921612.pdf 5 35 separator 0.91775537 ¶ 4704 4706 W2007921612.pdf 5 36 bibliography 0.9979954 "3. Song C, Qu Z, Blumm N, Baraba ́si AL (2010) Limits of predictability in human mobility. Science 327: 1018–1021." 4706 4823 W2007921612.pdf 5 37 separator 0.9265628 ¶ 4823 4825 W2007921612.pdf 5 38 bibliography 0.99758345 "4. Baraba ́si AL (2005) The origin of bursts and heavy tails in human dynamics. Nature 435: 207–211." 4825 4928 W2007921612.pdf 5 39 separator 0.9646607 ¶ 4928 4930 W2007921612.pdf 5 40 bibliography 0.9978898 "5. Johansen A (2004) Probing human response times. Physica A 338: 286–291.6. Eckmann JP (2004) Entropy of dialogues creates coherent structures in e-mail traffic. Proc Natl Acad Sci U S A 101: 14333–14337." 4930 5138 W2007921612.pdf 5 41 separator 0.9735967 ¶ 5138 5140 W2007921612.pdf 5 42 bibliography 0.99801314 "7. Va ́zquez A, Oliveira JG, Dezso ̈ Z, Goh KI, Kondor I, et al. (2006) Modeling bursts and heavy tails in human dynamics. Phys Rev E 73: 036127." 5140 5288 W2007921612.pdf 5 43 separator 0.8645362 ¶ 5288 5290 W2007921612.pdf 5 44 bibliography 0.99781245 "8. Va ́zquez A (2007) Impact of memory on human dynamics. Physica A 373: 747– 752." 5290 5375 W2007921612.pdf 5 45 separator 0.9407081 ¶ 5375 5377 W2007921612.pdf 5 46 bibliography 0.99794185 "9. 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Proc Natl Acad Sci U S A 107: 18803–18808." 6867 7033 W2007921612.pdf 5 69 separator 0.9231107 ¶ 7033 7035 W2007921612.pdf 5 70 bibliography 0.997883 "22. Jo HH, Pan RK, Kaski K (2012) Time-varying priority queuing models for human dynamics. Phys Rev E 85: 066102." 7035 7151 W2007921612.pdf 5 71 separator 0.8606599 ¶ 7151 7153 W2007921612.pdf 5 72 bibliography 0.99783945 "23. Hidalgo R CA (2006) Conditions for the emergence of scaling in the inter-event time of uncorrelated and seasonal systems. Physica A 369: 877–883." 7153 7305 W2007921612.pdf 5 73 separator 0.93062085 ¶ 7305 7307 W2007921612.pdf 5 74 bibliography 0.998003 "24. Malmgren D, Stouffer D, Campanharo A, Nunes Amaral L (2009) On universality in human correspondence activity. Science 325: 1696–1700." 7307 7447 W2007921612.pdf 5 75 separator 0.9097332 ¶ 7447 7449 W2007921612.pdf 5 76 bibliography 0.9977885 "25. Vajna S, To ́th B, Kerte ́sz J (2012) Modelling power-law distributed interevent times: arXiv: 1211.1175.Circadian and Bursty Pattern of Human Activities" 7449 7609 W2007921612.pdf 5 77 separator 0.9776763 ¶ 7609 7611 W2007921612.pdf 5 78 paratext 0.9822791 PLOS ONE | www.plosone.org 6 March 2013 | Volume 8 | Issue 3 | e58292 7611 7681 W2007921612.pdf 5 0 paratext 0.98164165 IUPAC Compendium of Chemical Terminology 28 of 1622PAC, 1993, 65, 2291 (Nomenclature of kinetic methods of analysis (IUPAC Recommendations 1993)) 0 146 W4246657974.pdf 75 1 separator 0.5466455 ¶ 146 148 W4246657974.pdf 75 2 paratext 0.9835899 on page 2294 148 161 W4246657974.pdf 75 3 separator 0.9334171 ¶ 161 163 W4246657974.pdf 75 4 paratext 0.5849051 PAC 163 167 W4246657974.pdf 75 5 bibliography 0.5194234 , 167 168 W4246657974.pdf 75 6 paratext 0.60620534 1994 168 173 W4246657974.pdf 75 7 bibliography 0.5080156 , 66, 173 178 W4246657974.pdf 75 8 paratext 0.6001348 1077 178 183 W4246657974.pdf 75 9 bibliography 0.6401095 ( 184 186 W4246657974.pdf 75 10 paratext 0.616637 Glossary 186 194 W4246657974.pdf 75 11 bibliography 0.58227843 "of terms used in physical organic chemistry (IUPAC " 194 248 W4246657974.pdf 75 12 paratext 0.52952695 Recommendations 248 263 W4246657974.pdf 75 13 bibliography 0.51506376 263 264 W4246657974.pdf 75 14 paratext 0.78644544 1994)) on page 1112 264 284 W4246657974.pdf 75 15 separator 0.99550796 ¶ 284 286 W4246657974.pdf 75 16 title 0.95988154 "activation in electrochemical corrosion" 286 328 W4246657974.pdf 75 17 separator 0.99336046 ¶ 328 330 W4246657974.pdf 75 18 text 0.99571985 "The process of transition from the passive to the active state by removal of the passivating film. A necessary condition for activation is an electrode potential negative to the equilibrium potential of formation of the passivating film . Activation is achieved by cathodic currents, by a reduced substance in the adjacent solution, or by contact with an electronic conductor having a suitably negative corrosion potential ." 330 765 W4246657974.pdf 75 19 separator 0.9764358 ¶ 765 767 W4246657974.pdf 75 20 bibliography 0.95444477 See also: passive state , active state 767 807 W4246657974.pdf 75 21 separator 0.928828 ¶ 807 809 W4246657974.pdf 75 22 bibliography 0.9949382 "Source: PAC, 1989, 61, 19 (Electrochemical corrosion nomenclature (Recommendations 1988)) on page 21" 809 913 W4246657974.pdf 75 23 separator 0.99519217 ¶ 913 915 W4246657974.pdf 75 24 title 0.9675997 "activation in radiochemistry" 915 946 W4246657974.pdf 75 25 separator 0.993647 ¶ 946 948 W4246657974.pdf 75 26 text 0.99906534 "The process of inducing radioactivity by irradiation. In general, a specification is added of the type of incident radiation (e.g. nuclear, neutron , photon) or its energy (e.g. thermal, fast)." 948 1146 W4246657974.pdf 75 27 separator 0.98434746 ¶ 1146 1148 W4246657974.pdf 75 28 bibliography 0.97167474 "Source: PAC, 1994, 66, 2513 (Nomenclature for radioanalytical chemistry (IUPAC Recommendations 1994)) on page 2515" 1148 1268 W4246657974.pdf 75 29 separator 0.9947581 ¶ 1268 1270 W4246657974.pdf 75 30 title 0.98509854 activation reaction 1270 1290 W4246657974.pdf 75 31 separator 0.99426794 ¶ 1290 1292 W4246657974.pdf 75 32 text 0.9973391 Process leading from the reactants to the formation of an activated complex or transition state . 1292 1391 W4246657974.pdf 75 33 separator 0.9491391 ¶ 1391 1393 W4246657974.pdf 75 34 bibliography 0.9356067 "Source: Physical Chemistry Division, unpublished" 1393 1444 W4246657974.pdf 75 35 separator 0.9844847 ¶ 1444 1446 W4246657974.pdf 75 36 title 0.8346154 activator 1446 1456 W4246657974.pdf 75 37 separator 0.9904796 ¶ 1456 1458 W4246657974.pdf 75 38 text 0.63755155 Also contains definition of : 1458 1488 W4246657974.pdf 75 39 title 0.85098714 enzyme activator 1488 1505 W4246657974.pdf 75 40 separator 0.9115302 ¶ 1505 1507 W4246657974.pdf 75 41 text 0.9988082 "A substance, other than the catalyst or one of the substrates, that increases the rate of a catalysed reaction without itself being consumed; the process is called activation . An activator of an enzyme- catalysed reaction may be called enzyme activator, if it acts by binding to the enzyme." 1507 1803 W4246657974.pdf 75 42 separator 0.86710566 ¶ 1803 1805 W4246657974.pdf 75 43 bibliography 0.80035216 See also: 1805 1815 W4246657974.pdf 75 44 text 0.5373272 effect 1816 1823 W4246657974.pdf 75 45 bibliography 0.5247401 or 1823 1825 W4246657974.pdf 75 46 separator 0.9551596 ¶ 1825 1827 W4246657974.pdf 75 47 bibliography 0.9942546 "Source: PAC, 1993, 65, 2291 (Nomenclature of kinetic methods of analysis (IUPAC Recommendations 1993))" 1827 1933 W4246657974.pdf 75 48 separator 0.7155076 ¶ 1933 1935 W4246657974.pdf 75 49 bibliography 0.94859207 on page 2292 1935 1948 W4246657974.pdf 75 0 text 0.86087877 "monitoring video data of diseases and pests. Application side is belonging to the final client . Users issue a surveillance request to the cloud storage service side used by the desktop computer, notebook computer or smartphone to check the video of diseases and pests at a remote place." 0 295 W2550734885.pdf 3 1 separator 0.99146426 ¶ 296 298 W2550734885.pdf 3 2 text 0.9660592 Sketch map of the o verall system structure is shown in Fig. 1. 298 363 W2550734885.pdf 3 3 separator 0.97873527 "¶ ¶" 364 374 W2550734885.pdf 3 4 caption 0.9866154 Fig. 1 Overall structure of the system 374 413 W2550734885.pdf 3 5 separator 0.99357873 ¶ 415 417 W2550734885.pdf 3 6 title 0.9920996 3Fundamental Function Modules 417 447 W2550734885.pdf 3 7 separator 0.99360013 ¶ 449 451 W2550734885.pdf 3 8 title 0.9903368 3.1 The Module of Acquisition Side 451 486 W2550734885.pdf 3 9 separator 0.9937241 ¶ 487 489 W2550734885.pdf 3 10 text 0.99964905 "The a cquisitionside mainly consists of high definition dome camera, hemispheric camera and some auxiliary equipment. According to the requirements of modern management style of fruit trees, in full fruit period, height of fruit trees often remain under about 3m. And the height of surveillance pole need higher than trees ’ height in order to observe the entire orchard. So the height of surveillance pole designs with about 3.5m.Surveillance pole adopts stainless steel material quality that not only ensured stiffness of bracket, but also prevents rain erosion and field weathering." 489 1100 W2550734885.pdf 3 11 separator 0.9717301 ¶ 1102 1104 W2550734885.pdf 3 12 text 0.99965835 "Cameras are fitted on the top and the middle of the survei llance pole. In order to observe the diseases and pests of the entire orchard, the top camera use a unibody waterproof dome camera that equipped with a 27 -power binocular lens. Lower -middle part of the surveillance pole, under the canopy of the fruit trees , uses a hemispheric camera thatequipped with a 10 -power binocular lens. Camera stretched into the tree canopy by means of the transverse branch arm to observe the occurrence status of diseases and pests. Similarly , tak ing rainfall issue into consideration , the sealed rainproof is installed on the external of the hemispheric camera. Physical picture of the surveillance pole is shown in Fig. 2." 1104 1849 W2550734885.pdf 3 13 separator 0.99700856 ¶ 1851 1853 W2550734885.pdf 3 0 paratext 0.85608935 "The rural super city - Central Lancashire New Town ." 0 55 W2935804856.pdf 0 1 separator 0.6922915 ¶ 56 58 W2935804856.pdf 0 2 paratext 0.6354139 "Victoria Jolley1,1 ¶ 1Manchester School of Architecture, UK." 58 125 W2935804856.pdf 0 3 separator 0.88071036 ¶ ¶ 127 133 W2935804856.pdf 0 4 text 0.99751097 "Abstract. From 1950 rural Lancashire, in England, became the focus of a major renewal scheme to accommodate population overspill from nearby cities of Liverpool and Manch ester. Over a period of 15 years the initial proposal for a series of self -contained new towns progressed into an ambitious s cheme for a single polycentric “supercity ” for 500,000 people." 133 511 W2935804856.pdf 0 5 separator 0.9619888 ¶ 513 515 W2935804856.pdf 0 6 text 0.99963367 "Known as Central Lancashire New Town and designed by RMJM, this part-realised development was the last and largest New Town designated under the 1965 Act. Its theoretical urban pattern, which followed new and proposed infrastructure, was unique. Based on a ladder system this straddled rich agricultural land and declining post -industrial townscapes to unify and expand existing settlements with the aim of generating prosperity on a sub -regional scale. CLNT was not completed but its planning phases can be traced across Lancashire’s urban and rural landscapes by built communications networks and city -scale public and civic buildings. Referencing three different new town typologies this paper will outline the project’s evol ution and identify the impact that designing for the motorcar and future change had on the provision of green space. This research has be en undertaken using previously “closed ” archival resources and architectural journal and local press articles." 515 1544 W2935804856.pdf 0 7 separator 0.9873204 "¶ ¶" 1546 1556 W2935804856.pdf 0 8 title 0.90594935 Introduction 1556 1569 W2935804856.pdf 0 9 separator 0.98553234 ¶ ¶ 1570 1576 W2935804856.pdf 0 10 text 0.9991678 "Designated in 1970 Central Lancashire New Town is significant because it was the last and largest of the third generation new towns proposed in Britain between 1967 and 1970 and it demonstrated an unprecedented application of the New Town Act. Set within rural Lancashire, CLNT is a part -realised sub -regional complex based on an interconnected series of urban townships. Inspired by the context’s poly -centricity, it focused on existing small towns and villages surrounding Preston, Chorley a nd Leyland and involved the creation of substantial new communities as well as the controlled expansion of existing settlements (Figure 1) . Prepared by Central Lancashire Development Corporation following extensive consultation, its strategy for delivery over a period of 30 years was released prior to a public inquiry as an Outline Plan in 1974 [1: 9]. This master -plan, prepared by Robert Matthew Johnson Marshall and Partners, accommodated a predicted population increase from 253,000 in 1966 to 503,000 in 1991 over 51,460 acres, 44,187 acres of which had been identified as suitable for development. Four key criteria needed to be satisfied – the integration of " 1576 2792 W2935804856.pdf 0 11 separator 0.87099457 ¶ ¶ 2792 2857 W2935804856.pdf 0 12 contact 0.9946213 1 Corresponding author: v.jolley@mmu.ac.uk 2857 2900 W2935804856.pdf 0 13 separator 0.51907045 2902 2903 W2935804856.pdf 0 14 paratext 0.9745346 "¶ © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/).SHS Web of Conferences 63, 05003 (2019) https://doi.org/10.1051/shsconf/20196305003" 2903 3186 W2935804856.pdf 0 15 separator 0.67420375 ¶ 3186 3188 W2935804856.pdf 0 16 paratext 0.96754044 MODSCAPES 2018 3188 3203 W2935804856.pdf 0 0 text 0.9811703 "guidance and regulation of actin cytoskeleton were also expressed at higher levels (Fig 3c)." 0 94 W3031517209.pdf 5 1 separator 0.9940636 ¶ 94 96 W3031517209.pdf 5 2 title 0.9904766 KITLG-related miRNA pro files 96 125 W3031517209.pdf 5 3 separator 0.9855882 ¶ 125 127 W3031517209.pdf 5 4 text 0.99934185 "miRNA data was excavated from TCGA-THYM to fur- ther explore the correlati on with KITLG expression. A total of 79 positive and 78 negative miRNAs were identi- fied (P<0 . 0 5 , P e a r s o n R>0 . 5 o r< −0.5, Fig 4a). As previous studies reported , some of these miRNAs were closely associated with thymoma or the thymus. As for upregulated miRNA, miR-125a regulates FOXP3 expres- sion and modulates the different in flammatory signaling pathways; this might be associated with thymoma with myasthenia gravis.20High expression of miR-34a might modulate thymoma cell differentiation and develop- ment.21As for downregulated miRNA, miR-106 can tar- get MEK2, which might affect the thymus ’immune function.22Meanwhile, MEK2 is a member of the MAPKsignaling pathway, which was also upregulated in type A and AB thymoma, as previously mentioned. miR-363 could regulate TNF receptor superfamily member 5 and cyclin-dependent kinase inhibitor 1A, which mightinfluence the tumor cell cycle." 127 1142 W3031517209.pdf 5 5 separator 0.95134425 ¶ 1142 1144 W3031517209.pdf 5 6 text 0.98725724 "23Low levels of miR-20b expression were also evident in thymoma. MiR-20b acts as a tumor suppressor in the development of thymomaby repression of NFAT5 and CAMTA1 expression to inhibit NFAT signaling." 1144 1351 W3031517209.pdf 5 7 separator 0.64445376 ¶ 1351 1353 W3031517209.pdf 5 8 text 0.99064076 "24MiR-7 can control CCL21 release, which is essential for thymoma germinal centerdevelopment." 1353 1449 W3031517209.pdf 5 9 separator 0.93818647 ¶ 1449 1451 W3031517209.pdf 5 10 text 0.9858417 "25The differentially expressed miRNAs are also presented with KITLG expression in a heatmap (Fig 4b). An interaction n etwork of differentially expressed miRNAs and KITLG was established using Cytoscape 3.7.126to further demonstrate their relation- ship (Fig 4c). KITLG as the core was at the center of thenetwork. The upregulated miRNAs are represented by pink rounded rectangles, while the downregulated miRNAs are labeled by green rounded rectangles." 1451 1919 W3031517209.pdf 5 11 separator 0.99574316 ¶ 1919 1921 W3031517209.pdf 5 12 caption 0.9963666 "Figure 4 KITLG related genome-wide microRNAs pro files. (a) Volcano plot of positive and negative microRNAs. ( b) Heatmap of microRNAs associ- ated with KITLG. The top curve shows KITLGs expression distribution of 121 thymoma samples. ( c) Interaction network of differentially expressed microRNAs and KITLG." 1921 2233 W3031517209.pdf 5 13 separator 0.97289044 ¶ 2233 2235 W3031517209.pdf 5 14 paratext 0.971314 Thoracic Cancer 11(2020) 1944 –1954 © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd 1949Z. Yang et al. KITLG for type A and AB thymoma 2235 2434 W3031517209.pdf 5 0 text 0.98742485 jOR=1.6). 0 9 W4388503548.pdf 5 1 separator 0.60199165 ¶ 12 14 W4388503548.pdf 5 2 text 0.9960462 "¶ Including unsalted nuts and seeds in one ’s diet (p<0.001) was associated with ageing while on ART. At multivariate analysis, there was a reduc- tion in the odds of ageing among respondents who included unsalted nuts and seeds in their diet and (from unadjOR=2.2 to adjOR=1.8). ¶ Regularly adding salt to food during cooking (p=0.004) was associated with ageing while on ART. Multivariate analysis revealed that there was a reduction in the odds of ageing among respond- ents who regularly added salt to their food during cooking (from unadjOR=3.1 to adjOR=2.6). ¶ Hence at bivariate level, the nutrition factors that were found associated with ageing while on ART were confidence about current nutrition knowledge (p<0.001), eating breakfast (p=0.016), preference for half the plate being fruits/vegetables (p<0.001), including unsalted nuts and seeds in one ’s diet (p<0.001) and regularly adding salt to food during cooking (p=0.004). ¶ At multivariate analysis, the odds of ageing among respondents who eat breakfast remained the same, while there was a 10% increase in the odds for re- spondents who were confident about their nutrition knowledge from 0.4 to 0.5 (adjOR=0.5; 95%CI 0.3 -0.7). While there was a reduction in the odds of ageing among respondents who preferred that half their plate consisted of fruits or vegetables (from unadjOR=2.0 to adjOR=1.6), those who included unsalted nuts and seeds in their diet and (from un- adjOR=2.2 to adjOR=1.8) and those who regularly added salt to their food during cooking (from unad- jOR=3.1 to adjOR=2.6), these respondents still had higher odds compared to those that had responded “no” to these components." 16 1786 W4388503548.pdf 5 3 separator 0.99715114 ¶ 1788 1790 W4388503548.pdf 5 4 title 0.99310094 Table 2: Relationship between ageing and nutrition factors 1790 1849 W4388503548.pdf 5 5 separator 0.9971299 ¶ 1851 1853 W4388503548.pdf 5 6 text 0.9965791 "In summary, Confidence about current nutrition knowledge, (p<0.001), eating breakfast (p=0.039), pref- erence for half the plate consisting of fruits or vegetables (p=0.031), including unsalted nuts and seeds in Variable Unadj OR (95% p-value Adj. OR (95% p-value" 1853 2120 W4388503548.pdf 5 7 separator 0.96267176 ¶ 2121 2123 W4388503548.pdf 5 8 table 0.9945844 "Confident about current nutrition knowledge No Yes 1 (Reference) 0.4 (0.3-0.6) ¶ <0.001* 1 (Reference) 0.5 (0.3-0.7) ¶ <0.001* Eat breakfast No Yes 1 (Reference) 0.5 (0.3-0.9) ¶ 0.018* 1 (Reference) 0.5 (0.3-1.0) ¶ 0.039* Prefer that half your plate is fruits/vegetables No Yes 1 (Reference) 2.0 (1.4-2.8) ¶ <0.001* (Reference) 1.6 (1.0-2.3) ¶ 0.031* Include unsalted nuts and seeds in diet No Yes 1 (Reference) 2.2 (1.4-3.5) ¶ <0.001* (Reference) 1.8 (1.1-2.9) ¶ 0.013* Regularly add salt to food during cooking No Yes 1 (Reference) 3.1 (1.4-6.9) ¶ 0.006* 1 (Reference) 2.6 (1.1-5.9) ¶ 0.028* * Denotes statistical significant at p<0.05" 2123 2951 W4388503548.pdf 5 9 separator 0.9927465 ¶ 2961 2963 W4388503548.pdf 5 10 paratext 0.9838174 AJMCRR, 2023 Volume 2 | Issue 11 | 6 of 10 2963 3162 W4388503548.pdf 5 11 separator 0.99257547 ¶ 3164 3166 W4388503548.pdf 5 0 paratext 0.9882648 Page 9 of 9 0 11 W3085847135.pdf 8 1 separator 0.8152652 ¶ 11 13 W3085847135.pdf 8 2 paratext 0.9684182 Lv et al. Parasites Vectors (2020) 13:475 14 65 W3085847135.pdf 8 3 separator 0.95132685 ¶ ¶ 66 72 W3085847135.pdf 8 4 text 0.5395206 • 72 74 W3085847135.pdf 8 5 separator 0.42076045 74 75 W3085847135.pdf 8 6 text 0.6060769 "¶ fast, convenient online submission • " 75 118 W3085847135.pdf 8 7 table 0.45895848 ¶ 118 119 W3085847135.pdf 8 8 text 0.6841857 thorough peer review by experienced researchers in your field 121 183 W3085847135.pdf 8 9 table 0.47556058 ¶ 183 184 W3085847135.pdf 8 10 text 0.4997573 • 184 188 W3085847135.pdf 8 11 table 0.47613946 ¶ 188 189 W3085847135.pdf 8 12 text 0.70461965 "rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations " 190 381 W3085847135.pdf 8 13 separator 0.49803314 ¶ 381 382 W3085847135.pdf 8 14 text 0.77931154 maximum visibility for your research: over 100M website views per year • 383 456 W3085847135.pdf 8 15 separator 0.903258 ¶ 456 458 W3085847135.pdf 8 16 text 0.62872654 At BMC, research is always in progress. 460 500 W3085847135.pdf 8 17 separator 0.62396383 ¶ 500 502 W3085847135.pdf 8 18 text 0.6788527 Learn more biomedcentral.com/submissionsReady to submit y our researc h ? Choose BMC and benefit fr om: 502 607 W3085847135.pdf 8 19 separator 0.9952159 ¶ 608 610 W3085847135.pdf 8 20 bibliography 0.997522 "21. Brosson D, Kuhn L, Delbac F, Garin J, Vivarès PC. Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi (microsporidia): a refer - ence map for proteins expressed in late sporogonial stages. Proteomics. 2006;6:3625–35." 611 856 W3085847135.pdf 8 21 separator 0.9763236 ¶ 856 858 W3085847135.pdf 8 22 bibliography 0.9978965 22. Becnel JJ, Andreadis TG. Microsporidia in insects. Microsporidia. 2014:521–70. 859 942 W3085847135.pdf 8 23 separator 0.9634843 ¶ 942 944 W3085847135.pdf 8 24 bibliography 0.9981037 23. Han B, Polonais V, Sugi T, Yakubu R, Takvorian PM, Cali A, et al. The role of microsporidian polar tube protein 4 (PTP4) in host cell infection. PLoS Pathog. 2017;13:e1006341. 945 1125 W3085847135.pdf 8 25 separator 0.9597746 ¶ 1125 1127 W3085847135.pdf 8 26 bibliography 0.9979723 24. Liu FY, Ma Q, Dang XQ, Wang Y, Song Y, Meng XZ, et al. Identification of a new subtilisin-like protease NbSLP2 interacting with cytoskeletal protein septin in Microsporidia Nosema bombycis. J Invertebr Pathol. 2017;148:110–7. 1128 1358 W3085847135.pdf 8 27 separator 0.97019315 ¶ 1358 1360 W3085847135.pdf 8 28 bibliography 0.9979353 "25. Corsaro D, Walochnik J, Venditti D, Steinmann J, Müller KD, Michel R. Microsporidia-like parasites of amoebae belong to the early fungal line - age Rozellomycota. Parasitol Res. 2014;113:1909–18." 1361 1563 W3085847135.pdf 8 29 separator 0.9761814 ¶ 1563 1565 W3085847135.pdf 8 30 bibliography 0.9978289 26. Wang Y, Geng HX, Dang XQ, Xiang H, Li T. Comparative analysis of the proteins with tandem repeats from 8 microsporidia and characteriza-tion of a novel endospore wall protein colocalizing with polar tube from Nosema bombycis. J Eukaryot Microbiol. 2017;64:707–15. 1566 1834 W3085847135.pdf 8 31 separator 0.9788002 ¶ 1834 1836 W3085847135.pdf 8 32 bibliography 0.99792963 27. Han B, Takvorian PM, Weiss LM. Invasion of host cells by microsporidia. Front Microbiol. 2020;11:172–4. 28. Taupin V, Garenaux E, Mazet M, Maes E, Denise H, Prensier G. Major O-glycans in the spores of two microsporidian parasites are represented by unbranched manno-oligosaccharides containing α-1,2 linkages. Glycobiology. 2006;17:56–67. 1837 2181 W3085847135.pdf 8 33 separator 0.9785666 ¶ 2181 2183 W3085847135.pdf 8 34 bibliography 0.9979543 29. He Q, Luo J, Xu JZ, Meng XZ, Pan GQ, Li T. In-vitro cultivation of Nosema bombycis sporoplasms: a method for potential genetic engineering of microsporidia. J Invertebr Pathol. 2020;174:107420. 2184 2382 W3085847135.pdf 8 35 separator 0.9684671 ¶ 2382 2384 W3085847135.pdf 8 36 bibliography 0.9979213 30. Bohne W, Böttcher K, Groß U. The parasitophorous vacuole of Encepha-litozoon cuniculi: biogenesis and characteristics of the host cell–pathogen interface. Int J Med Microbiol. 2011;301:395–9. 2385 2581 W3085847135.pdf 8 37 separator 0.9725902 ¶ 2581 2583 W3085847135.pdf 8 38 bibliography 0.9978726 "31. Magaud A, Achbarou A, Desportes-Livage I. Cell invasion by the micro - sporidium Encephalitozoon intestinalis. J Eukaryot Microbiol. 1997;44:81–3." 2584 2737 W3085847135.pdf 8 39 separator 0.9679373 ¶ 2737 2739 W3085847135.pdf 8 40 bibliography 0.99793553 "32. Schottelius J, Schmetz C, Kock NP , Schüler T, Sobottka I, Fleischer B. Presentation by scanning electron microscopy of the life cycle of micro - sporidia of the genus Encephalitozoon. Microbes Infect. 2000;2:1401–6." 2740 2963 W3085847135.pdf 8 41 separator 0.9561855 ¶ 2963 2965 W3085847135.pdf 8 42 bibliography 0.99783695 33. Bigliardi E, Sacchi L. Cell biology and invasion of the microsporidia. Microbes Infect. 2001;3:373–9. 2966 3072 W3085847135.pdf 8 43 separator 0.9899392 ¶ 3072 3074 W3085847135.pdf 8 44 title 0.97795695 Publisher’s Note 3074 3091 W3085847135.pdf 8 45 separator 0.97848874 ¶ 3091 3093 W3085847135.pdf 8 46 text 0.8478648 "Springer Nature remains neutral with regard to jurisdictional claims in pub - lished maps and institutional affiliations." 3093 3217 W3085847135.pdf 8 0 paratext 0.9901747 Educ. Sci. 2023 ,13, 542 9 of 19 0 32 W4378222719.pdf 8 1 separator 0.9954103 ¶ 32 34 W4378222719.pdf 8 2 text 0.99665713 "each coach and the classroom practice that was the focus of each observation (e.g., class- room climate)." 34 142 W4378222719.pdf 8 3 separator 0.91352 ¶ 142 144 W4378222719.pdf 8 4 text 0.99873304 "We assessed the impact of CHALK by comparing the covariate-adjusted mean outcome values between the CHALK and usual coaching groups. We evaluated the impact of the intervention on the classroom observation measures by comparing mean values across the CHALK and usual coaching conditions at the intermediate and year-end time points." 144 483 W4378222719.pdf 8 5 separator 0.96398556 ¶ 483 485 W4378222719.pdf 8 6 text 0.999484 "The child assessment analysis used a complete case sample of children who had both pretest and posttest assessments. We used a two-level model with a random intercept clustered at the coach level (i.e., the level of the randomization). The model also contained covariates for the baseline assessment value, child age at the baseline assessment, days between the start of the school year and the baseline assessment, days between the baseline and endline assessment, child race, and child gender." 485 991 W4378222719.pdf 8 7 separator 0.9970578 ¶ 991 993 W4378222719.pdf 8 8 title 0.9885607 3. Results 993 1004 W4378222719.pdf 8 9 separator 0.9970024 ¶ 1004 1006 W4378222719.pdf 8 10 text 0.99961317 "We first compared the demographic characteristics of our participants at the baseline, calculating effect sizes between conditions using the COX transformation [ 38]. Child gender was balanced across the CHALK and usual coaching samples, but there were substantial racial and age imbalances across conditions. The CHALK sample was 60% Black and 34% White, whereas the usual coaching sample was 80% Black and 17% White." 1006 1432 W4378222719.pdf 8 11 separator 0.9039204 ¶ 1432 1434 W4378222719.pdf 8 12 text 0.9996235 "We then calculated effect sizes for age in months and age in months at assessment date and compared the number of days between pretest and posttest assessments by estimating Hedges’ g[39]. We found that the two conditions were also imbalanced in terms of child age. The CHALK students were two months older on September 1st of the school year and one month older at assessment than students in the usual coaching condition. This translates to a standardized mean difference of 0.32 between the child ages on September 1st and a standardized mean difference of 0.12 at assessment. This was due to the baseline child assessments being collected later, on average, for the usual coaching group than for the CHALK group. The mean assessment day for the CHALK group was 79 days after September 1st, and the mean assessment day for the usual coaching group was 100 days after September 1st ( g= 0.60). This produced average ages that were closer together at assessment for the two conditions but also meant that children in the usual coaching condition had more time in preschool before their baseline assessments were collected than did children in the CHALK condition. None of the demographic or assessment timing differences were statistically significant at the 0.05 level." 1434 2733 W4378222719.pdf 8 13 separator 0.9971942 ¶ 2733 2735 W4378222719.pdf 8 14 title 0.9917395 3.1. Implementation Study 2735 2761 W4378222719.pdf 8 15 separator 0.9969398 ¶ 2761 2763 W4378222719.pdf 8 16 text 0.999676 "Focus of coaching. All coaches and teachers reported that their primary focus for coaching was their respective PLC topic, but five of the coaches added that they used each observation and subsequent conversation as an opportunity to assess teachers’ in- dividual instructional needs and then adjusted the focus to fit teachers’ needs. Six of the seven coaches described choosing a coaching focus in collaboration with their teachers (two CHALK coaches and all of the control group coaches)." 2763 3263 W4378222719.pdf 8 17 separator 0.9271393 ¶ 3263 3265 W4378222719.pdf 8 18 text 0.999597 "“So with the PLC that they’re in, the topics are already laid out because we do a book study. It is—it’s with what we’re going through in the book. So that’s how we do it. But if I was going in to observe the classroom, I would take that tool and say, okay, is she doing any number? And it’s good because now I’m more aware and aware is the big thing. And intentional and being aware is the game in this tool ”. (chalk coach)" 3265 3699 W4378222719.pdf 8 19 separator 0.9606166 ¶ 3699 3701 W4378222719.pdf 8 20 text 0.99955606 "“My PLC topic is very important and I feel like that I just can’t get enough of it. And it’s so good information that every time we review it, we get a new piece ”. (chalk teacher)" 3701 3884 W4378222719.pdf 8 21 separator 0.960788 ¶ 3884 3886 W4378222719.pdf 8 22 text 0.9995657 "“So I think it depends on their goals or what they’re specifically working on. So who can I think of? Well, I can think of [Teacher], the girl who I talked about. She’s been working on, with her large group time, student engagement ”. (chalk Coach)" 3886 4138 W4378222719.pdf 8 0 paratext 0.94188875 839Web Inventory of Transcribed and Translated Talks. 0 53 W3152995402.pdf 9 1 separator 0.9701197 ¶ 53 55 W3152995402.pdf 9 2 bibliography 0.9026812 "InProceedings of the 16th EAMT Conference , pages 261–268, Trento, Italy." 55 131 W3152995402.pdf 9 3 separator 0.9852654 ¶ 131 133 W3152995402.pdf 9 4 bibliography 0.99611986 "Rajen Chatterjee, Matteo Negri, Marco Turchi, Mar- cello Federico, Lucia Specia, and Fr ́ed ́eric Blain." 133 239 W3152995402.pdf 9 5 separator 0.8535845 ¶ 239 241 W3152995402.pdf 9 6 bibliography 0.996429 "2017. Guiding Neural Machine Translation Decod- ing with External Knowledge. In Proceedings of the Second Conference on Machine Translation , pages 157–168, Copenhagen, Denmark. Association for Computational Linguistics." 241 470 W3152995402.pdf 9 7 separator 0.98061186 ¶ 470 472 W3152995402.pdf 9 8 bibliography 0.9970177 "Georgiana Dinu, Prashant Mathur, Marcello Federico, and Yaser Al-Onaizan. 2019. Training Neural Ma- chine Translation to Apply Terminology Constraints." 472 628 W3152995402.pdf 9 9 separator 0.8666402 ¶ 628 630 W3152995402.pdf 9 10 bibliography 0.9965981 "InProceedings of the 57th Annual Meeting of the Association for Computational Linguistics , pages 3063–3068, Florence, Italy. Association for Compu- tational Linguistics." 630 807 W3152995402.pdf 9 11 separator 0.97601295 ¶ 807 809 W3152995402.pdf 9 12 bibliography 0.997054 "Yarin Gal and Zoubin Ghahramani. 2016. A Theoreti- cally Grounded Application of Dropout in Recurrent Neural Networks. In Proceedings of the 30th Inter- national Conference on Neural Information Process- ing Systems , NIPS’16, pages 1027–1035, Barcelona, Spain. Curran Associates Inc." 809 1104 W3152995402.pdf 9 13 separator 0.98453075 ¶ 1104 1106 W3152995402.pdf 9 14 bibliography 0.9964096 "Eva Hasler, Adri `a de Gispert, Gonzalo Iglesias, and Bill Byrne. 2018. Neural Machine Translation De- coding with Terminology Constraints. In Proceed- ings of the 2018 Conference of the North Ameri- can Chapter of the Association for Computational Linguistics: Human Language Technologies, Vol- ume 2 (Short Papers) , pages 506–512, New Orleans, Louisiana. Association for Computational Linguis- tics." 1106 1525 W3152995402.pdf 9 15 separator 0.98270917 ¶ 1525 1527 W3152995402.pdf 9 16 bibliography 0.9973119 "Chris Hokamp and Qun Liu. 2017. Lexically Con- strained Decoding for Sequence Generation Using Grid Beam Search. In Proceedings of the 55th An- nual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers) , pages 1535– 1546, Vancouver, Canada. Association for Computa- tional Linguistics." 1527 1853 W3152995402.pdf 9 17 separator 0.9834964 ¶ 1853 1855 W3152995402.pdf 9 18 bibliography 0.9950026 "Catherine Kobus, Josep Crego, and Jean Senellart. 2017. Domain Control for Neural Machine Trans- lation. In Proceddings of Recent Advances in Natu- ral Language Processing (RANLP 2017) , pages 372– 378, Varna, Bulgaria." 1855 2083 W3152995402.pdf 9 19 separator 0.97289807 ¶ 2083 2085 W3152995402.pdf 9 20 bibliography 0.99734855 "Philipp Koehn. 2005. Europarl: A Parallel Corpus for Statistical Machine Translation. In Proceedings The Tenth Machine Translation Summit (MT Summit X) , Phuket, Thailand." 2085 2263 W3152995402.pdf 9 21 separator 0.9802665 ¶ 2263 2265 W3152995402.pdf 9 22 bibliography 0.99770445 "Thomas Lavergne, Hai-Son Le, Alexandre Allauzen, and Franc ̧ois Yvon. 2011. LIMSI’s experiments in domain adaptation for IWSLT11. In Proceedings of the International Workshop on Spoken Langugage Translation , pages 62–67, San Francisco, CA." 2265 2514 W3152995402.pdf 9 23 separator 0.9837389 ¶ 2514 2516 W3152995402.pdf 9 24 bibliography 0.99765027 Ya Li, Xinyu Liu, Dan Liu, Xueqiang Zhang, and J. Liu. 2516 2571 W3152995402.pdf 9 25 separator 0.7106993 ¶ 2571 2573 W3152995402.pdf 9 26 bibliography 0.9951467 "2019. Learning Efficient Lexically-Constrained Neural Machine Translation with External Memory." 2573 2670 W3152995402.pdf 9 27 separator 0.96967435 ¶ 2670 2672 W3152995402.pdf 9 28 bibliography 0.9908489 "ArXiv , abs/1901.11344.Minh-Thang Luong and Christopher D. Manning. 2015. Stanford Neural Machine Translation Systems for Spoken Language Domains. In Proceedings of the Twelfth International Workshop on Spoken Lan- guage Translation (IWSLT 2015) , Da Nang, Viet- nam." 2672 2950 W3152995402.pdf 9 29 separator 0.98165864 ¶ 2950 2952 W3152995402.pdf 9 30 bibliography 0.9975395 "Jan Niehues, Eunah Cho, Thanh Le Ha, and Alex Waibel. 2016. Pre-translation for neural machine translation. In COLING 2016 - 26th International Conference on Computational Linguistics, Proceed- ings of COLING 2016: Technical Papers , pages 1828–1836, Osaka, Japan." 2952 3227 W3152995402.pdf 9 31 separator 0.9788102 ¶ 3227 3229 W3152995402.pdf 9 32 bibliography 0.9975835 "Jan Niehues and Alex Waibel. 2011. Using Wikipedia to translate domain-specific terms in SMT. In Proceedings of the 8th International Workshop on Spoken Language Translation (IWSLT 2011) , pages 230–237." 3229 3440 W3152995402.pdf 9 33 separator 0.9828619 ¶ 3440 3442 W3152995402.pdf 9 34 bibliography 0.99749464 "Kishore Papineni, Salim Roukos, Todd Ward, and Wei- Jing Zhu. 2002. Bleu: a method for automatic eval- uation of machine translation. In Proceedings of the 40th Annual Meeting of the Association for Com- putational Linguistics , pages 311–318, Philadelphia, Pennsylvania, USA. Association for Computational Linguistics." 3442 3774 W3152995402.pdf 9 35 separator 0.98245573 ¶ 3774 3776 W3152995402.pdf 9 36 bibliography 0.9968296 "Ngoc-Quan Pham, Thai-Son Nguyen, Jan Niehues, Markus M ̈uller, Sebastian St ̈uker, and Alexander Waibel. 2019. Very Deep Self-Attention Networks for End-to-End Speech Recognition. In Proceed- ings of the 20th Annual Conference of the Inter- national Speech Communication Association (Inter- speech 2019) , Graz, Austria." 3776 4109 W3152995402.pdf 9 37 separator 0.97332716 ¶ 4109 4111 W3152995402.pdf 9 38 bibliography 0.9976472 Ngoc-Quan Pham, Jan Niehues, and Alex Waibel. 4111 4157 W3152995402.pdf 9 39 separator 0.62737024 4157 4158 W3152995402.pdf 9 40 bibliography 0.98905104 "¶ 2018. Towards one-shot learning for rare-word translation with external experts. In Proceedings of the Second Workshop on Neural Machine Transla- tion, Melbourne, Australia." 4158 4339 W3152995402.pdf 9 41 separator 0.9818008 ¶ 4339 4341 W3152995402.pdf 9 42 bibliography 0.9966606 "Matt Post and David Vilar. 2018. Fast Lexically Con- strained Decoding with Dynamic Beam Allocation for Neural Machine Translation. In Proceedings of the 2018 Conference of the North American Chap- ter of the Association for Computational Linguistics: Human Language Technologies, Volume 1 (Long Pa- pers) , pages 1314–1324, New Orleans, Louisiana." 4341 4702 W3152995402.pdf 9 43 separator 0.711645 ¶ 4702 4704 W3152995402.pdf 9 44 bibliography 0.9944368 Association for Computational Linguistics. 4704 4747 W3152995402.pdf 9 45 separator 0.9823385 ¶ 4747 4749 W3152995402.pdf 9 46 bibliography 0.99736184 "Peng Qi, Yuhao Zhang, Yuhui Zhang, Jason Bolton, and Christopher D. Manning. 2020. Stanza: A Python Natural Language Processing Toolkit for Many Human Languages. In Proceedings of the 58th Annual Meeting of the Association for Compu- tational Linguistics: System Demonstrations ." 4749 5039 W3152995402.pdf 9 47 separator 0.9804814 ¶ 5039 5041 W3152995402.pdf 9 48 bibliography 0.9943248 "Rico Sennrich. 2017. How Grammatical is Character- level Neural Machine Translation? Assessing MT Quality with Contrastive Translation Pairs. In Pro- ceedings of the 15th Conference of the European Chapter of the Association for Computational Lin- guistics: Volume 2, Short Papers , pages 376–382, Valencia, Spain. Association for Computational Lin- guistics." 5041 5415 W3152995402.pdf 9 0 paratext 0.9810173 "1785 Trindade Neto et al. R. Bras. Zootec., v.39, n.8, p.1784-1790, 2010" 0 74 W2101116610.pdf 1 1 title 0.8423788 Introduction 74 86 W2101116610.pdf 1 2 separator 0.9957125 ¶ 86 88 W2101116610.pdf 1 3 text 0.9963442 "The low performance of piglets after weaning is partly caused by the poorly developed digestive systemand the fact that it is not accustomed to dry food. The first two weeks after weaning are characterized as transitory phase for the piglet and it may be characterizedby anorexic situations and damages on the production of digestive enzymes as well as on the intestinal villous. Under these circumstances, the diet digestibility and useof nutrients may change over time after weaning. On the other hand, feed composition and nutritional requirement tables do not consider this aspect." 88 688 W2101116610.pdf 1 4 separator 0.9733766 ¶ 688 690 W2101116610.pdf 1 5 text 0.99376 "Dietary ingredients with high digestibility and that are compatible with the piglet physiologic conditions require some considerations. The high inclusion of lactosesource is a better alternative to substitute starch, whose use efficiency is lower in piglets due to its chemical complexity (Mahan & Newton, 1993; Tokach et al., 1995).As observed by Barbosa et al. (1999); Soares et al. (2000) and Trindade Neto et al. (2002), the diet quality during the initial period of post-weaning may influence overallanimal performance, with influences on weight and age at finishing phase." 690 1284 W2101116610.pdf 1 6 separator 0.9650732 ¶ 1284 1286 W2101116610.pdf 1 7 text 0.9997312 "The efficiency of piglet initial diet after weaning will depend, at some extent, on anatomical and physiological development of the gastrointestinal tract from the suckling phase (Owsley et al., 1986). At birth, the gastrointestinalsystem of the pig is immature and the changes in digestive enzyme secretions reflect on a fast increase of some nutrients digestibility. However, after weaning, very fasttransformation occurs in the gastrointestinal tract, especially during the first week." 1286 1787 W2101116610.pdf 1 8 separator 0.9453062 ¶ 1787 1789 W2101116610.pdf 1 9 text 0.9996537 "The changes in the piglet gastrointestinal tract after weaning are caused by the type of food and by post- weaning transitory anorexia (Montagne et al., 2007). This anorexia affects digestive enzyme secretion (Marion et al.,2003) and intestinal villous size (Berto et al., 1996), however, the animal may have a fast recovery (Marion et al., 2003; McCracken, et al., 1999). Therefore, the digestibility and retention of some nutrients by the piglet may change from one week to another. Nevertheless, published nutritional tables do not specify the age and body weightof the animals used in determining the published values in the immediate post-weaning phase." 1789 2466 W2101116610.pdf 1 10 separator 0.95038795 ¶ 2466 2468 W2101116610.pdf 1 11 text 0.9962418 "The objective this study was to determine the apparent digestibility of diets with variable concentrations of digestible lysine and metabolizable energy in piglets in the first weeks after weaning." 2468 2672 W2101116610.pdf 1 12 title 0.9920815 Material and Methods 2672 2692 W2101116610.pdf 1 13 separator 0.9956119 ¶ 2692 2694 W2101116610.pdf 1 14 text 0.99969125 "Forty-eight castrated piglets, obtained from a commercial farm, were used in this trial. The piglets were divided intotwo groups of 24 per group based on age and weight. Thefirst group was weaned one week earlier than the secondgroup, thus at the start of the experiment, the first groupweighed 12.73 ± 0.99 kg and at the age of 35 days while the second group weighed 8.68 ± 0.76 kg at 28 days of age. From weaning to start of the experimental adaptation, the pigletsfrom the first group received the same diet (pre-initialphase). The piglets, housed in metabolism crates, weresubmitted to 13 days in evaluation period, during whichseven were an adaptation period when feed was offered ad libitum. However, 24 hours before the collection period, all piglets were weighed to calculate metabolic weight (BW 0.75) and feed intakes during the collection period were based onmetabolic weight as described by Matterson et al. (1965).Total fecal and urine collections were carried out in the lastsix days as described by Barbosa et al. (1985). Ferric oxide was used as fecal marker. Apparent digestibility of dry matter, nitrogen and energy were determined." 2694 3863 W2101116610.pdf 1 15 separator 0.9713491 ¶ 3863 3865 W2101116610.pdf 1 16 text 0.99975085 "This study was designed as a follow-up to the study by Trindade Neto et al. (2009) in which the ratio betweendigestible lysine and metabolizable energy for nurserypiglets (6.90 ± 1.11 kg) was evaluated. The results of this study showed that increase in metabolizable energy resulted in a higher nitrogen retention, whereas increase in lysinereduced nitrogen retention. In the current study, four levelsof digestible lysine (1.222; 1.305; 1.390 and 1.497%) andthree levels of metabolizable energy (3510, 3700 and3830 kcal/kg of food) were separetely evaluated at two body weight categories. Other nutritional requirements (Table 1) were formulated to meet minimal requirements assuggested by NRC (1998) and Rostagno et al. (2005)." 3865 4605 W2101116610.pdf 1 17 separator 0.9743718 ¶ 4605 4607 W2101116610.pdf 1 18 text 0.99967694 "The study was designed as a randomized block design with a fact orial arrangement. Each pig was considered an experimental unit and initial weight was used to form the blocks. When digestible lysine was considered, the factorial scheme was 2 × 4 with six replications. Whenmetabolizable energy was considered, the factorial schemewas 2 × 3 with eight replications. The body weights werethe following: 12.73 kg (35 days of age) and 8.68 (28 daysof age). The data was analyzed by using the GLM procedure of SAS (SAS, 2004)." 4607 5140 W2101116610.pdf 1 19 separator 0.996295 ¶ 5140 5142 W2101116610.pdf 1 20 title 0.991811 Results and Discussion 5142 5165 W2101116610.pdf 1 21 separator 0.99585485 ¶ 5165 5167 W2101116610.pdf 1 22 text 0.99960107 "During the experimental period, the room temperature ranged from 19.4 ± 1.2oC to 25.2 ± 1.0oC. Due to the piglet" 5167 5283 W2101116610.pdf 1 0 paratext 0.6774392 272 0 3 W2131259510.pdf 5 1 title 0.98919326 THE IDLE ACTOR IN AESCHYLUS 3 31 W2131259510.pdf 5 2 separator 0.9928738 ¶ 31 33 W2131259510.pdf 5 3 text 0.99869823 "as, for example, in that of the Merchant of Venice, in which the Duke, as judge, remains silent for some 213 lines, and Antonio, the prisoner, for about 325 lines." 33 201 W2131259510.pdf 5 4 separator 0.6113385 ¶ 201 203 W2131259510.pdf 5 5 text 0.99838567 "The silence is inherent in the situation—forced upon the poet, if one will have it so, by the circumstances of the scene. But for the choice of the scene he alone is responsible." 203 386 W2131259510.pdf 5 6 separator 0.813774 ¶ 386 388 W2131259510.pdf 5 7 text 0.9994109 "The silences of the Eumenides, therefore, like that of the Agamemnon, afford no evidence whatever to show what the poet may have done when handling an entirely different problem. Moreover, just as it would be absurd to ascribe the silence of Antonio and the Duke to Shakespeare's inability to keep the wholenumber of actors employed, so it is manifestly a mistake to cite this scene of theEumenides as illustrating the alleged difficulty which Aeschylus encountered in trying to keep three actors employed at once (p. 29). Quite as little warrant, also, is there for citing the silence of Cassandra in this connection (p. 29)." 388 1025 W2131259510.pdf 5 8 separator 0.9764358 ¶ 1025 1027 W2131259510.pdf 5 9 text 0.9946314 "There seems to be, therefore, little support 1 for the conclusion that ' the analogy of extant scenes suggests that' Achilles and Niobe were shown as silent figures because ' the poet did not know what else to do with them ' (p. 43). On the contrary, in view of the bold ingenuity of the poet in devising spectaculareffects, it remains not merely a possibility but a probability that these and,perhaps, other characters also were so represented for the sake of the picture, thoughnot necessarily for the purpose suggested by Aristophanes, to exaggerate the effectof the actor's words. Indeed it seems, more than likely that Eustathius—basing his remark, doubtless, upon some earlier source, now lost—was right when he statedthat Aeschylus, in such scenes, was imitating Homer." 1027 1818 W2131259510.pdf 5 10 separator 0.98364294 ¶ 1818 1820 W2131259510.pdf 5 11 paratext 0.4486505 2 1820 1822 W2131259510.pdf 5 12 separator 0.94507986 ¶ 1822 1824 W2131259510.pdf 5 13 contact 0.9684797 "JAMES TURNEY ALLEN. UNIVERSITY OF CALIFORNIA. Dec. 6, 1906." 1824 1888 W2131259510.pdf 5 14 separator 0.9914099 ¶ 1888 1890 W2131259510.pdf 5 15 text 0.9911694 "1 With regard to the Choephori I do not agree in that play the chorus did not enter singing. Cf. with Dr. Dignan when he thinks that Electra sits on also the Antigone. As for the Septem the arguments the step of the altar during the parodos. That the brought forward in support of the view that Eteocles vase paintings which represent her in this attitude do remained on the scene during the parodos (see above) not refer to this particular scene is shown by the are not conclusive. It seems, therefore, hardly justi- presence of Orestes in them. Tucker (pp. cit. p. 14) fiable to cite this as an instance of the idle actor in supposes that the absence of anapaests indicates that Aeschylus. the ode was not sung until the chorus reached the a See also M. Croiset, ' Eschyle Imitateur orchestra. But the parodos of the Oed. Tyr. has no d'Homere,' Rev. d. &tudes Grecques, vii. 151 sqq. anapaests : yet no one supposes, so far as I know, that" 1890 2856 W2131259510.pdf 5 0 table 0.98081607 "70AB 160 140 120 100 80604020 060 50403020 10 0 20 30 Panobinostat dose (mg)R= 0.361 P= 0.023P= 0.034 P= 0.333Panobinostat plasma level (ng/mL) Panobinostat plasma level (ng/mL) 40 50 60 1/2 3/4 PD CB Toxicity grade" 0 245 W2303007295.pdf 4 1 separator 0.9867332 ¶ 245 247 W2303007295.pdf 4 2 caption 0.98691076 "Figure 2. Relationship between panobinostat plasma concentration and dose, response, and toxicity. (A) Panobinostat plasma concentration (ng/ml) exhibit s a positive correlation with dose (mg). (B) Box plots of panobinostat plasma concentrations (ng/ml) in patients who immediately progressed (PD) vers us those who experienced clinical bene fit (CB) and in patients who experienced grade 1/2 toxicities versus those who experienced grade 3/4 toxicities. Correlations were conducted using Pearson ’s correlation coef ficient method." 247 784 W2303007295.pdf 4 3 separator 0.96531475 ¶ 784 786 W2303007295.pdf 4 4 table 0.9917347 "P= 0.538R= 0.124 080100 60 4020 0 20 40 Panobinostat plasma level (ng/mL)Relative acetylation (X-fold)B 6080R= 0.062 60 4020 0 20 30 40 Panobinostat dose (mg)Relative acetylation (X-fold)A 50 60 P= 0.0046 P= 0.0054 P= 0.251.8 1.61.41.21.0 0.8 0.6 0.4 0.2 PD CB WBC0DRelative to pre treatment PD CB ANCPD CB LymphoP= 0.915 P= 0.041 PD 1/2 3/4 Toxicity gradeCB80100C 60 40 20 0Relative acetylation (X-fold)" 786 1251 W2303007295.pdf 4 5 separator 0.99167836 ¶ 1251 1253 W2303007295.pdf 4 6 caption 0.99361074 "Figure 3. Peripheral blood mononucleocyte histone acetylation relationship to panobinostat dose and plasma concentration, response, toxicity, and white c ell count. Histone acetylation neither correlates with panobinostat dose (A) nor plasma concentration (ng/ml, B). (C) Box plots of histone acetylation in patients who did (CB) versus those who did not (PD) bene fit from treatment and in patients who experienced grade 1/2 versus grade 3/4 toxicity. (D) Dot plots of all leukocytes (WBC), neutrophils (ANC), and lymphocytes (Lympho) on day 5 of treatment normalized to pretreatment on day 1 of cycle 1 comparing patientswho did (CB) and did not (PD) bene fit from treatment. The bar indicates the mean. Correlations were conducted using Pearson ’s correlation coef ficient method." 1253 2042 W2303007295.pdf 4 7 separator 0.971908 ¶ 2042 2044 W2303007295.pdf 4 8 paratext 0.9739025 Volume 27 | No. 5 | May 2016 doi:10.1093/annonc/mdw044 | Annals of Oncology original articles 2044 2141 W2303007295.pdf 4 0 paratext 0.97130823 "Genomics and evolutionary biology | Human biology and medicine Jinek et al. eLife 2013;2:e00471. DOI: 10.7554/eLife.00471 6 of 9" 0 134 W2153344788.pdf 5 1 separator 0.9594141 ¶ 134 136 W2153344788.pdf 5 2 title 0.8581413 Research article 136 153 W2153344788.pdf 5 3 separator 0.8894202 ¶ 153 155 W2153344788.pdf 5 4 text 0.9992733 "engineered for each new cleavage site. RNA-guided genome editing would thus offer distinct advan - tages due to the simplicity of the sgRNA design." 155 305 W2153344788.pdf 5 5 separator 0.5800625 ¶ 305 307 W2153344788.pdf 5 6 text 0.9994171 "Our results thus provide the framework for implementing Cas9 as a facile molecular tool for diverse genome editing applications. Although not tested explicitly in this study, a powerful feature of this system is the potential to program Cas9 with multiple sgRNAs in the same cell, either to increase the efficiency of targeting at a single locus, or as a means of targeting several loci simultaneously. Such strategies would find broad application in genome-wide experiments and large-scale research efforts such as the development of multigenic disease models. As an inexpensive and rapid mechanism for triggering site-specific genome modification, the programmable Cas9:sgRNA system could potentially transform next-generation genome- scale studies." 307 1079 W2153344788.pdf 5 7 separator 0.99399495 ¶ 1079 1081 W2153344788.pdf 5 8 caption 0.97193074 "Figure 3 . 3′ extension of sgRNA constructs enhances site-specific NHEJ-mediated mutagenesis. ( A) The construct for CLTA1 sgRNA expression (top) was designed to generate transcripts containing the original Cas9-binding sequence v1.0 ( Jinek et al., 2012 ), or sequences extended by 4 base pairs (v2.1) or 10 base pairs (v2.2). ( B) Surveyor nuclease assay of genomic DNA isolated from HEK293T cells expressing Cas9 and/or CLTA sgRNA v1.0, v2.1 or v2.2. A ZFN construct previously used to target the CLTA locus ( Do" 1081 1609 W2153344788.pdf 5 9 text 0.51598155 yon 1609 1612 W2153344788.pdf 5 10 caption 0.69638556 et al., 1612 1620 W2153344788.pdf 5 11 text 0.67372185 2011 1620 1625 W2153344788.pdf 5 12 caption 0.8182368 ") was used as a positive control for detecting DSB-induced DNA repair by non-homologous end joining." 1625 1729 W2153344788.pdf 5 13 separator 0.9739677 ¶ 1729 1731 W2153344788.pdf 5 14 paratext 0.98125196 DOI: 10.7554/eLife.00471.006 1731 1760 W2153344788.pdf 5 0 paratext 0.99039966 Page 8/25 0 9 W4292457494.pdf 7 1 separator 0.9937072 ¶ 9 11 W4292457494.pdf 7 2 text 0.9807304 et al. (2009) used the impact function to obtain RIF estimates of various distributional statistics of health 11 121 W4292457494.pdf 7 3 separator 0.913375 ¶ 121 123 W4292457494.pdf 7 4 text 0.9927517 status (such as quantile, variance, Gini coe 123 168 W4292457494.pdf 7 0 text 0.57802725 speed n = 30558 min-1 (ω = 3200 rad/s 0 38 W3181479967.pdf 5 1 caption 0.7700026 ). Figures 10 -12 38 56 W3181479967.pdf 5 2 separator 0.9283531 ¶ 57 59 W3181479967.pdf 5 3 caption 0.96924007 show the SSS on the hull under working conditions 59 109 W3181479967.pdf 5 4 separator 0.78820205 ¶ ¶ 111 117 W3181479967.pdf 5 5 caption 0.80137825 a) b) 117 168 W3181479967.pdf 5 6 separator 0.9784107 ¶ 169 171 W3181479967.pdf 5 7 caption 0.99455553 "Fig. 10. Equivalent tensions in sector (a) and into the grinding head opening (b) ." 171 258 W3181479967.pdf 5 8 separator 0.50769234 "¶ ¶" 259 269 W3181479967.pdf 5 9 caption 0.50420713 271 272 W3181479967.pdf 5 10 separator 0.4977144 ¶ 272 273 W3181479967.pdf 5 11 caption 0.95437115 a) b) 273 324 W3181479967.pdf 5 12 separator 0.94239914 ¶ 326 328 W3181479967.pdf 5 13 caption 0.99255735 Fig. 11. Radial movements (a) and axial movements (b) . 328 384 W3181479967.pdf 5 14 separator 0.978987 ¶ 385 387 W3181479967.pdf 5 15 text 0.80848014 "The greatest stresses are in the grinding head holes and ar e l ocal i n n ature. Equivalent voltages i n t hem σekqmax = 948 MPa. Equivalent plastic deformation in the holes εр = 0,3%. Voltages in the astragal molding of the carrier p in fabric 7 22 MP a." 387 658 W3181479967.pdf 5 16 table 0.46343645 V oltages in t he 658 676 W3181479967.pdf 5 17 text 0.47600532 "hub 6 04 MPa." 676 693 W3181479967.pdf 5 18 separator 0.9708139 ¶ ¶ 694 700 W3181479967.pdf 5 19 caption 0.7834167 "Fig. 12. Equivalent plastic deformation Radial movements: flange bores (83 mm diameter) UR = 0,0137 mm; grinding head bores on the abrasive side (105 mm diameter) UR = 0,127 mm." 700 895 W3181479967.pdf 5 20 table 0.47856346 "¶ Axial movements: grinding head holes on the abrasive side (105 mm diameter) U Z = 0,07 mm." 897 998 W3181479967.pdf 5 21 separator 0.95638925 ¶ 1000 1002 W3181479967.pdf 5 22 text 0.9976202 "The body in the central part is evenly stretched out radially and narrowed axially. The periphery of the casing b ends t o t he abrasive s ide. When cal culated according to the two -dimensional scheme of the stress state with stress averaging on the thickness of the disk, the safety margin Km = 2.132 in the center of the disk." 1002 1346 W3181479967.pdf 5 23 separator 0.9771786 ¶ 1348 1350 W3181479967.pdf 5 24 caption 0.47526366 Inventory at destructive speed Kv = 1350 1387 W3181479967.pdf 5 25 table 0.4033163 1.619. 1387 1394 W3181479967.pdf 5 26 separator 0.99624574 ¶ 1396 1398 W3181479967.pdf 5 27 title 0.99240273 Calculating mandrel and spindle 1398 1430 W3181479967.pdf 5 28 separator 0.99483854 ¶ 1432 1434 W3181479967.pdf 5 29 text 0.99815625 "In o rder t o as sess the failure t o o pen t he joint between the spindle and mandrel, calculations of these elements from the action of centrifugal forces were made. Figures 13 a nd 14 s how the equivalent stresses and radial movements. At the points of contact between the spindle and mandrel, the mandrel displacement is 3 μm, while the s pindle d isplacement is 0 .5 μ m. This results in a conicity of 1: 5 to the axial displacement of the mandrel by δ = (3 - 0.5) ∙5∙2 = 25 μm." 1434 1933 W3181479967.pdf 5 30 separator 0.84586 ¶ ¶ 1934 1940 W3181479967.pdf 5 31 math 0.29293495 1940 1941 W3181479967.pdf 5 32 text 0.33544978 a) 1941 1943 W3181479967.pdf 5 33 table 0.2981364 b) 1982 1985 W3181479967.pdf 5 34 separator 0.9818393 ¶ 1986 1988 W3181479967.pdf 5 35 caption 0.943442 "Fig. 13. Equivalent stresses in mandrel (a) and spindle (b) . ¶ a) b)" 1988 2104 W3181479967.pdf 5 36 separator 0.8747547 ¶ 2105 2107 W3181479967.pdf 5 37 caption 0.99479574 Fig. 14. Radial movements in mandrel (a) and spindle (b) . 2107 2166 W3181479967.pdf 5 38 separator 0.97794604 ¶ 2167 2169 W3181479967.pdf 5 39 text 0.9842839 "This movement causes the tightening to be loosened. For this reason, a special flow screw has been designed to compensate for axial movement." 2169 2315 W3181479967.pdf 5 40 separator 0.6293781 ¶ 2316 2318 W3181479967.pdf 5 41 text 0.748049 "Radial displacement o f flange bores (83 mm diameter) U R = 0.017 m m, a lmost id entical to th e movements of the housing flange." 2318 2458 W3181479967.pdf 5 42 separator 0.995395 ¶ 2460 2462 W3181479967.pdf 5 43 title 0.97281915 6 Conclusion 2462 2475 W3181479967.pdf 5 44 separator 0.99529535 ¶ 2477 2479 W3181479967.pdf 5 45 text 0.9909989 "This work leads us to the following conclusions : 1. The strength of high -speed grinding wheels has been cal culated. T wo v ariants o f ar rangement o f machining elements are considered: horizontally and at an angle of 45 degrees. The horizontal version of the grinding heads i s p referable. The cas ing d eforms uniformly without bending. Manufacturing this casing is less time-consuming. 2. The mandrel and spindle are calculated. According to calculation s, a special screw with a flow was designed to co mpensate t he a xial movement o f t he mandrel relative to the spindle. 3. Radial movements in the area of the flange holes (83 mm i n d iameter) a t t he ho using a nd mandrel a re nearly the same." 2479 3229 W3181479967.pdf 5 46 separator 0.996131 ¶ 3231 3233 W3181479967.pdf 5 47 title 0.9567053 Acknowledgments 3233 3249 W3181479967.pdf 5 48 separator 0.99197614 ¶ 3251 3253 W3181479967.pdf 5 49 text 0.989866 "The work was carried out with the financial support of the G rant C ouncil o f the President o f t he R ussian Federation for state support of young Russian scientists and for state support of leading scientific schools of the Russian Federation, grant number MD -345.2020.8." 3253 3535 W3181479967.pdf 5 50 separator 0.9649564 ¶ 3537 3539 W3181479967.pdf 5 51 paratext 0.98718256 6EPJ Web of Conferences 248, 04008 (2021) https://doi.org/10.1051/epjconf/202124804008 3539 3626 W3181479967.pdf 5 52 separator 0.69810736 ¶ 3626 3628 W3181479967.pdf 5 53 paratext 0.9780855 MNPS-2020 3628 3638 W3181479967.pdf 5 0 text 0.77739793 "Z-VAD induced cell death and significant IL-1 /H9251processing and release (Fig. 3 B)." 0 88 W2018334071.pdf 4 1 separator 0.9884089 ¶ 88 90 W2018334071.pdf 4 2 title 0.9354884 Necroptosis Induces IL-1 /H9251Release 90 129 W2018334071.pdf 4 3 text 0.9983059 "—Treatment of macro- phages with LPS and the pan-caspase inhibitor Z-VAD inducesRIP3-dependent necroptosis (22), a caspase-independent formof programmed necrosis. Necroptosis can be inhibited by theRIP1 inhibitor necrostatin-1 (NEC1) (23, 24). Thus, the data wepresent above (Fig. 3 B) suggested that in our LPS-primed BMDMs, Z-VAD induced necroptosis, that this drove IL-1 /H9251 processing and release, and that this was completely indepen-dent of IL-1 /H9252. To further confirm that necroptosis was regulat- ing the processing and release of IL-1 /H9251we incubated LPS- primed BMDMs with Z-VAD (100 /H9262M) in the absence or presence of the RIP1 inhibitor NEC1 (100 /H9262M). To determine whether necroptotic responses to LPS and Z-VAD were inflam-masome-dependent we also repeated the LPS and Z-VAD experiment in BMDMs isolated from NLRP3/H11002//H11002and ASC/H11002//H11002 mice (Fig. 4). Z-VAD induced cell death in LPS-primed BMDMs from WT, NLRP3/H11002//H11002, and ASC/H11002//H11002mice, and this was not significantly affected by NEC1 (Fig. 4 A). In LPS-primed BMDMs from all strains Z-VAD induced IL-1 /H9251release, and this was significantly inhibited by NEC1 (Fig. 4 C). There was no release of IL-1 /H9252over vehicle treatment (Fig. 4 B). Interestingly, the release of IL-1 /H9251from LPS- and Z-VAD-treated ASC/H11002//H11002 cells was lower than from WT or NLRP3/H11002//H11002cells, suggesting that under these conditions release of IL-1 /H9251may be partially ASC-dependent (Fig. 4 C). We repeated these experiments in primary mouse peritoneal macrophages, another cell type com-monly used to interrogate mechanisms of IL-1 release. In LPS-primed primary peritoneal macrophages, NEC1 (100 /H9262M)" 129 1896 W2018334071.pdf 4 4 separator 0.9897174 ¶ 1896 1898 W2018334071.pdf 4 5 caption 0.99632424 "FIGURE 3. Effects of YVAD and Z-VAD on apoptotic stimuli induced IL-1 release. BMDMs isolated from WT mice were treated with LPS (1 /H9262g/ml, 4 h) and then treated with CHX (100 /H9262M) or STS (5 /H9262M) in serum-free medium for 24 h. Cells were also incubated with or without the caspase-1 inhibitor YVAD (100 /H9262M (A) or the pan-caspase inhibitor Z-VAD (100 /H9262M,B), where indicated for the duration of the experiment (after LPS stimulation). Supernatants were collected and analyzed for cell death (-fold increase in LDH release over vehicle treatment ( i), IL-1/H9252release ( ii), and IL-1 /H9251release ( iii). Release of IL-1 was measured by ELISA." 1898 2570 W2018334071.pdf 4 6 separator 0.97590315 ¶ 2570 2572 W2018334071.pdf 4 7 caption 0.9882504 "Identification of the mature 17-kDa IL-1 species in supernatants was confirmed by Western blotting. All data are presented as the mean /H11006S.D. ( error bars ) from at least three separate experiments. Blots shown are representative. ***, p/H110210.001.Cell Death and the Regulation of IL-1" 2572 2867 W2018334071.pdf 4 8 separator 0.9808835 ¶ 2867 2869 W2018334071.pdf 4 9 paratext 0.95096755 15946 JOURNAL OF BIOLOGICAL CHEMISTRY 2869 2907 W2018334071.pdf 4 10 separator 0.65718913 ¶ 2907 2909 W2018334071.pdf 4 11 paratext 0.96084183 VOLUME 289 • NUMBER 23 • JUNE 6, 2014 2910 2948 W2018334071.pdf 4 0 paratext 0.95792085 "14 International Journal of Advanced Computing Scienc e and Engineering ISSN 2714-7533 Vol. 3, No. 1, April 2021, pp. 10-17" 0 128 W3196185915.pdf 4 1 separator 0.98877203 ¶ 130 132 W3196185915.pdf 4 2 contact 0.39220017 Saba 133 138 W3196185915.pdf 4 3 text 0.42810753 Azeez et.al ( 138 153 W3196185915.pdf 4 4 title 0.61631566 FPGA Implementation of High Speed and Area E fficient Three Operand Binary Adder 153 233 W3196185915.pdf 4 5 text 0.46124083 ) 233 234 W3196185915.pdf 4 6 separator 0.98801017 ¶ 236 238 W3196185915.pdf 4 7 text 0.99761873 "maximum length period of 2n for n-bit modulus opera nd. To perform the modulo-2 addition operation, it takes only single XOR logic. The prop osed PRBG method can reduce the large memory area used in the existing dual-CLCG method and also can achieve the full-length period of 2n." 238 525 W3196185915.pdf 4 8 separator 0.9957237 ¶ 526 528 W3196185915.pdf 4 9 title 0.9798533 4. Results 528 540 W3196185915.pdf 4 10 separator 0.9952141 ¶ 541 543 W3196185915.pdf 4 11 text 0.99852484 Result of the proposed design is implemented using Xilinx ISE for simulation and Synthesis. 543 635 W3196185915.pdf 4 12 separator 0.99016416 ¶ 636 638 W3196185915.pdf 4 13 text 0.5726438 16 BIT 3- 638 648 W3196185915.pdf 4 14 title 0.46686232 OPERAND ADDER 648 661 W3196185915.pdf 4 15 text 0.62144595 : 661 662 W3196185915.pdf 4 16 separator 0.80346227 ¶ 663 665 W3196185915.pdf 4 17 caption 0.458663 Simulation: 665 677 W3196185915.pdf 4 18 separator 0.5128139 ¶ ¶ 678 684 W3196185915.pdf 4 19 caption 0.9479824 Fig. 2 Simulation. 684 703 W3196185915.pdf 4 20 separator 0.50284505 ¶ 705 707 W3196185915.pdf 4 21 caption 0.7294434 Synthesis Result: ¶ 707 728 W3196185915.pdf 4 22 separator 0.55974597 ¶ 730 732 W3196185915.pdf 4 23 caption 0.9419316 Fig 3. RTL Schematic. 732 754 W3196185915.pdf 4 24 separator 0.5141195 ¶ ¶ 756 762 W3196185915.pdf 4 25 caption 0.79453194 "Fig 4. Design Summary. " 762 792 W3196185915.pdf 4 26 separator 0.555427 ¶ 792 793 W3196185915.pdf 4 27 caption 0.95351475 Fig 5. Timing Summary. 793 816 W3196185915.pdf 4 28 separator 0.98974335 ¶ ¶ 817 823 W3196185915.pdf 4 0 paratext 0.6175258 On 0 2 W2513740014.pdf 4 1 title 0.5875846 Caccioppoli-Kannan type fixed point 2 38 W2513740014.pdf 4 2 paratext 0.75566643 principle 1005 38 52 W2513740014.pdf 4 3 separator 0.9948508 ¶ 52 54 W2513740014.pdf 4 4 text 0.98491246 "Letting n→∞ we then obtain d(u, Tu)≤a1(u, Tu). which implies u=Tu. This contradicts the property (ii) for n= 1. Hence the possibility Tkx=uor Tkx=Tufor some k∈Ncan not stand." 54 233 W2513740014.pdf 4 5 separator 0.9296425 ¶ 233 235 W2513740014.pdf 4 6 text 0.99444425 Now by (iii) of Definition 2.1 and condition (A) of Theorem 3.1, we obtain 235 309 W2513740014.pdf 4 7 separator 0.81511027 ¶ 309 311 W2513740014.pdf 4 8 math 0.9445639 "d(u, Tu)≤d(u, Tnx)+d(Tnx,Tn+1x)+d(Tn+1x,Tu) ≤d(u, Tnx)+d(Tnx,Tn+1x)+a1[d(Tnx,Tn+1x)+d(u, Tu)] ≤1 1−a1[d(u, Tnx) + (1 + a1)an 1−a1d(x, Tx)],b y(2)." 311 466 W2513740014.pdf 4 9 separator 0.93531823 ¶ 466 468 W2513740014.pdf 4 10 text 0.9926312 Letting n→∞ we get u=Tu. Hence Thas a fixed point in X. 468 523 W2513740014.pdf 4 11 separator 0.9514492 ¶ 523 525 W2513740014.pdf 4 12 text 0.9484753 "Case II . In this case we assume that Tpx=Trxfor some p, r∈N,p/negationslash=r. Let p>r. Then Tp−r(Trx)=Trx, i.e.,Tky=y, where k=p−r≥1, y=Trx∈X." 525 674 W2513740014.pdf 4 13 separator 0.8431674 ¶ 674 676 W2513740014.pdf 4 14 text 0.7269377 Now for k 676 686 W2513740014.pdf 4 15 math 0.75369704 "=1 ,Ty=y.F o rk>1,d(y,Ty)=d(Tky,Tk+1y) ≤ak 1−a1d(y,Ty) , or, (1 −ak 1−a1)d(y,Ty)≤0." 686 775 W2513740014.pdf 4 16 text 0.48697037 775 776 W2513740014.pdf 4 17 separator 0.5492096 ¶ 776 777 W2513740014.pdf 4 18 text 0.98818755 "Since k>1,a1+ak<1 and so d(y,Ty) = 0, i.e., Ty=yand so Thas a fixed point in X." 777 858 W2513740014.pdf 4 19 separator 0.5599816 ¶ 858 860 W2513740014.pdf 4 20 text 0.84333974 "For uniqueness of the fixed point let Tu=uandTv=v;u, v∈X. So,d(u, v)=d(Tu.Tv )≤a1[d(u, Tu)+d(v,Tv)] = 0. Hence u=v. " 860 978 W2513740014.pdf 4 21 separator 0.52987707 ¶ 978 979 W2513740014.pdf 4 22 text 0.98871297 This proves the theorem. 979 1004 W2513740014.pdf 4 23 separator 0.98599994 ¶ 1004 1006 W2513740014.pdf 4 24 text 0.9785771 "Remark 3.1. We show that Kannan’s fixed point theorem in generalized metric space (Theorem 2.6) and in metric space (Theorem 2.5) follow from our Theorem 3.1." 1006 1168 W2513740014.pdf 4 25 separator 0.97989213 ¶ 1168 1170 W2513740014.pdf 4 26 text 0.77070296 Proof of Theorem 2.6. 1170 1192 W2513740014.pdf 4 27 math 0.7906144 "d(Tx,Ty )≤(β α)α[d(x, Tx)+d(y,Ty)], whrere 0<α=β 1−β<1." 1192 1254 W2513740014.pdf 4 28 separator 0.8579241 ¶ 1254 1256 W2513740014.pdf 4 29 text 0.9903036 Using method of induction we easily prove that 1256 1303 W2513740014.pdf 4 30 separator 0.48595145 ¶ 1303 1305 W2513740014.pdf 4 31 math 0.7805781 "d(Tnx,Tny)≤(β α)αn[d(x, Tx)+d(y,Ty)] =an[d(x, Tx)+d(y,Ty)], where an=(β α)αn<β<1 2" 1305 1396 W2513740014.pdf 4 32 text 0.4828796 as 1396 1398 W2513740014.pdf 4 33 math 0.57020336 0<α< 1398 1403 W2513740014.pdf 4 34 text 0.96973574 "1, which implies that all the conditions of Theorem 3.1 are satisfied and hence by Theorem 3.1, Thas a unique fixed point in X." 1403 1533 W2513740014.pdf 4 35 separator 0.9895919 ¶ 1533 1535 W2513740014.pdf 4 36 text 0.8181742 "Acknowledgement: The first author acknowledges TEQIP-II (sub comp. 1. 2 ) grant of JIS College of Engineering, Kalyani, India for providing publication charges." 1535 1699 W2513740014.pdf 4 37 separator 0.99304473 ¶ 1699 1701 W2513740014.pdf 4 38 title 0.54978776 References 1701 1712 W2513740014.pdf 4 39 separator 0.986493 ¶ 1712 1714 W2513740014.pdf 4 40 bibliography 0.9959813 "1. A. Branciary, A fixed point theorem of Banach-Caccioppoli type on a class of generalized metric space, Publ. Math. Debrecen, (2000), (57), 1-2, 31." 1714 1866 W2513740014.pdf 4 0 text 0.9996101 "Initially, our research group established a protocol designed as a daily reduction in caloric intake in zebrafish. For this task, cohorts of both young and old fish raised in the zebrafish facility were moved to round glass aquaria ( Figure 1a and b). Fish were fed individually in 600 mL beakers during the weekdays ( Figure 1c and Table 2 ). On the weekend, fish were fed similar amounts of food in the housing aquaria. It should be noted that the animals were not housed continually in the beakers since zebrafish are highly social [ 83, 84 ], and continuous social isolation would increase their stress levels [ 85]. Since the effects of CR are thought to be modulated through the target of rapamycin (TOR) pathway [ 86], we aimed to test whether we could mimic the effects of CR with rapamycin treatment, a TOR inhibitor. Rapamycin is a macrocyclic compound produced by bacterium Streptomyces hygroscopicus and approved for patient use by the Food and Drug Administration (FDA, USA) [ 87]. The rapamycin group was treated daily with 100 nM rapamycin dissolved in DMSO. The fish in all treatment groups" 0 1142 W2807187732.pdf 9 1 separator 0.97795236 ¶ 1143 1145 W2807187732.pdf 9 2 caption 0.97588146 "Figure 1. Aquaria set-up for CR and rapamycin treatment (a–d), and IF and rapamycin treatment (e) experiments.Zebrafish Aging Models and Possible Interventions http://dx.doi.org/10.5772/intechopen.7555411" 1145 1353 W2807187732.pdf 9 0 paratext 0.97270954 G. R. van der Werf et al.: Globalfire emissions 11731 0 52 W3004727452.pdf 24 1 separator 0.90774775 ¶ 52 54 W3004727452.pdf 24 2 paratext 0.53552055 References 54 65 W3004727452.pdf 24 3 separator 0.97173035 ¶ 65 67 W3004727452.pdf 24 4 bibliography 0.9978861 "Achard, F., Eva, H. D., Mayaux, P., Stibig, H. J., and Belward, A.: Improved estimates of net carbon emissions from land cover changeinthetropicsforthe1990s,GlobalBiogeochem.Cy.,18, GB2008, doi:10.1029/2003GB002142, 2004." 67 295 W3004727452.pdf 24 5 separator 0.9499607 ¶ 295 297 W3004727452.pdf 24 6 bibliography 0.9928898 "Amiro, B. D., Todd, J. B., Wotton, B. M , Logan, K. A., Flannigan, M.D.,Stocks,B.J.,Mason,J.A.,Martell,D.L.,andHirsch,K. " 297 421 W3004727452.pdf 24 7 separator 0.5455559 ¶ 421 422 W3004727452.pdf 24 8 bibliography 0.9977965 "G.: Direct carbon emissions from Canadian forest fires, 1959– 1999, Can. J. Forest Res., 31, 512–525, 2001." 422 531 W3004727452.pdf 24 9 separator 0.94771564 ¶ 531 533 W3004727452.pdf 24 10 bibliography 0.99797064 "Andreae, M. O., and Merlet, P.: Emission of trace gases and aerosolsfrombiomassburning,Glob.Biogeochem.Cy.,15,955- 966, 2001." 533 663 W3004727452.pdf 24 11 separator 0.9503755 ¶ 663 665 W3004727452.pdf 24 12 bibliography 0.99777 "Aragao,L.E.O.C.,Malhi,Y.,Barbier,N.,Lima,A.,Shimabukuro, Y., Anderson, L., and Saatchi, S.: Interactions between rainfall, deforestation and fires during recent years in the Brazilian Amazonia, Philos. T. R. Soc. B, 363, 1779–1785, doi:10.1098/rstb.2007.0026, 2008." 665 938 W3004727452.pdf 24 13 separator 0.9620446 ¶ 938 940 W3004727452.pdf 24 14 bibliography 0.99757737 "Arino, O., Rosaz, J. M., and Poloup, P.: The ATSR World Fire At- lasandaSynergywithPOLDERAerosolProducts,Proceedings of the International Workshop on the Applications of the ERS Along Track Scanning Radiometer, 8, 1999." 940 1166 W3004727452.pdf 24 15 separator 0.96124065 ¶ 1166 1168 W3004727452.pdf 24 16 bibliography 0.9979121 "Arora, V. K. and Boer, G. J.: Fire as an interactive component of dynamic vegetation models, J. Geophys. Res.-Biogeo, 110, G02008, doi:10.1029/2005JG000042, 2005." 1168 1335 W3004727452.pdf 24 17 separator 0.9518515 ¶ 1335 1337 W3004727452.pdf 24 18 bibliography 0.99795496 "Ballhorn, U., Siegert, F., Mason, M., and Limin, S.: Derivation of burnscardepthsandestimationofcarbonemissionswithLIDAR in Indonesian peatlands, P. Natl. Acad. Sci. USA, 106, 21213– 21218, doi:10.1073/pnas.0906457106, 2009." 1337 1568 W3004727452.pdf 24 19 separator 0.9495888 ¶ 1568 1570 W3004727452.pdf 24 20 bibliography 0.9979521 "Batjes, N. H.: Total carbon and nitrogen in the soils of the world, Eur. J. Soil Sci., 47, 151–163, 1996." 1570 1678 W3004727452.pdf 24 21 separator 0.9508653 ¶ 1678 1680 W3004727452.pdf 24 22 bibliography 0.99793375 "Boby, L. A., Schuur, E. A. G., Mack, M. C., Verbyla, D., and John- stone, J. F.: Quantifying fire severity, carbon, and nitrogen emis- sions in Alaska’s boreal forest, Ecol. Appl., 20(6), 1633–1647, doi:10.1890/08-2295.1, 2010." 1680 1913 W3004727452.pdf 24 23 separator 0.94842625 ¶ 1913 1915 W3004727452.pdf 24 24 bibliography 0.9975167 "Bowman,D.M.J.S.,Balch,J.K.,Artaxo,P.,Bond,W.J.,Carlson, J.M.,Cochrane,M.A.,D’Antonio,C.M.,DeFries,R.S.,Doyle, J. C., Harrison, S. P., Johnston, F. H., Keeley, J. E., Krawchuk, M. A., Kull, C. A., Marston, J. B., Moritz, M. A., Prentice, I. C., Roos, C. I., Scott, A. C., Swetnam, T. W., van der Werf, G. R., andPyne,S.J.: FireintheEarthSystem,Science,324,481–484, doi:10.1126/science.1163886, 2009." 1915 2326 W3004727452.pdf 24 25 separator 0.9492767 ¶ 2326 2328 W3004727452.pdf 24 26 bibliography 0.99790996 "Chang, D., and Song, Y.: Estimates of biomass burning emissions in tropical Asia based on satellite-derived data, Atmos. Chem. Phys., 10, 2335–2351, doi:10.5194/acp-10-2335-2010, 2010." 2328 2517 W3004727452.pdf 24 27 separator 0.95704675 ¶ 2517 2519 W3004727452.pdf 24 28 bibliography 0.9972246 "Chevallier, F., Fortems, A., Bousquet, P., Pison, I., Szopa, S., De- vaux, M., and Hauglustaine, D. A.: African CO emissions be- tweenyears2000and2006asestimatedfromMOPITTobserva- tions,Biogeosciences,6,103–111,doi:10.5194/acp-6-103-2009, 2009." 2519 2772 W3004727452.pdf 24 29 separator 0.9636785 ¶ 2772 2774 W3004727452.pdf 24 30 bibliography 0.99794877 "Chuvieco,E.,Giglio,L.,&Justice,C.O.: Globalcharacterizationof fireactivity: towarddefiningfireregimesfromEarthobservation data. Global Change Biol., 14, 1488–1502, doi:10.1111/j.1365- 2486.2008.01585.x, 2008." 2774 2986 W3004727452.pdf 24 31 separator 0.9649385 ¶ 2986 2988 W3004727452.pdf 24 32 bibliography 0.99701864 "Christian, T. J., Kleiss, B., Yokelson, R. J., Holzinger, R., Crutzen, P. J., Hao, W. M., Saharjo, B. H., and Ward, D. E.: Comprehen- sive laboratory measurements of biomass-burning emissions: 1. EmissionsfromIndonesian,African,andotherfuels,J.Geophys. Res.-Atmos, 108, 4719, doi:10.1029/2003JD003704, 2003." 2988 3304 W3004727452.pdf 24 33 separator 0.9604802 ¶ 3304 3306 W3004727452.pdf 24 34 bibliography 0.9944653 "Cramer,W.P.andLeemans,R.: Global30-YearMeanMonthlyCli-matology, 1930–1960, V[ersion]. 2.1. Data set, available online at:http://www.daac.ornl.gov , from Oak Ridge National Labora- tory Distributed Active Archive Center, Oak Ridge, Tennessee, USA, doi:10.3334/ORNLDAAC/416, 2001." 3306 3591 W3004727452.pdf 24 35 separator 0.9793606 ¶ 3591 3593 W3004727452.pdf 24 36 bibliography 0.997972 "Crutzen, P. J. and Andreae, M. O: Biomass burning in the trop- ics: Impact on atmospheric chemistry and biogeochemical cy- cles, Science, 250, 1669–1678, 1990." 3593 3757 W3004727452.pdf 24 37 separator 0.9680364 ¶ 3757 3759 W3004727452.pdf 24 38 bibliography 0.9978344 "de Groot, W. J., Landry, R., Kurz, W. A., Anderson, K. R., Engle- field, P., Fraser, R. H., Hall, R. J., Banfield, E., Raymond, D. A., Decker,V.,Lynham,T.J.,andPritchard,J.M.: Estimatingdirect carbonemissionsfromCanadianwildlandfires1,Int.J.Wildland Fire, 16, 593–606, doi:10.1071/WF06150, 2007." 3759 4060 W3004727452.pdf 24 39 separator 0.94822997 ¶ 4060 4062 W3004727452.pdf 24 40 bibliography 0.99757636 "de Groot, W. J., Pritchard, J. M., and Lynham, T. J.: Forest floor fuelconsumptionandcarbonemissionsinCanadianborealforest fires, Can. J. Forest Res., 39, 367–382, doi:10.1139/X08-192, 2009." 4062 4257 W3004727452.pdf 24 41 separator 0.96966755 ¶ 4257 4259 W3004727452.pdf 24 42 bibliography 0.9978727 "DeFries, R. S., Houghton, R. A., Hansen, M. C., Field, C. B., Skole, D., and Townshend, J.: Carbon emissions from tropical deforestationandregrowthbasedonsatelliteobservationsforthe 1980s and 1990s, P. Natl. Acad. Sci. USA, 99, 14256–14261, doi:10.1073/pnas.182560099, 2002." 4259 4542 W3004727452.pdf 24 43 separator 0.96918106 ¶ 4542 4544 W3004727452.pdf 24 44 bibliography 0.99771655 "Defries, R. S., Morton, D. C., van der Werf, G. R., Giglio, L., Col- latz, G. J., Randerson, J. T., Houghton, R. A., Kasibhatla, P. K., and Shimabukuro, Y.: Fire-related carbon emissions from land use transitions in southern Amazonia, Geophys. Res. Lett., 35, L22705, doi:10.1029/2008GL035689, 2008." 4544 4852 W3004727452.pdf 24 45 separator 0.9610676 ¶ 4852 4854 W3004727452.pdf 24 46 bibliography 0.9979765 "Duncan, B. N., Martin, R. V., Staudt, A. C., Yevich, R., and Lo- gan, J. A.: Interannual and seasonal variability of biomass burn- ing emissions constrained by satellite observations, J. Geophys. Res.-Atmos, 108, 4100, doi:10.1029/2002JD002378, 2003." 4854 5111 W3004727452.pdf 24 47 separator 0.9538663 ¶ 5111 5113 W3004727452.pdf 24 48 bibliography 0.99796677 "Ellicott, E., Vermote, E., Giglio, L., and Roberts, G.: Estimating biomass consumed from fire using MODIS FRE, Geophys. Res. Lett., 36, 1–5, doi:10.1029/2009GL038581, 2009." 5113 5289 W3004727452.pdf 24 49 separator 0.9533596 ¶ 5289 5291 W3004727452.pdf 24 50 bibliography 0.9979013 "Fearnside, P. M.: Deforestation in Brazilian Amazonia: History, rates, and consequences, Conserv. Biol., 19, 680–688, 2005." 5291 5417 W3004727452.pdf 24 51 separator 0.9624071 ¶ 5417 5419 W3004727452.pdf 24 52 bibliography 0.9978218 "Field, C. B., Randerson, J. T., and Malmstrom, C. M.: Global net primary production – combining ecology and remote sensins, Remote. Sens. Environ, 51, 74–88, 1995." 5419 5587 W3004727452.pdf 24 53 separator 0.97160125 ¶ 5587 5589 W3004727452.pdf 24 54 bibliography 0.99792117 "Field,R.D.,vanderWerf,G.R.,andShen,S.S.P.: Humanampli- fication of drought-induced biomass burning in Indonesia since 1960, Natl. Geosci., 2, 185–188, doi:10.1038/NGEO443, 2009." 5589 5770 W3004727452.pdf 24 55 separator 0.96943355 ¶ 5770 5772 W3004727452.pdf 24 56 bibliography 0.9980308 "French,N.H.F.,Goovaerts,P.,andKasischke,E.S.: Uncertaintyin estimatingcarbonemissionsfromborealforestfires,J.Geophys. Res.-Atmos, 109, D14S08, doi:10.1029/2003JD003635, 2004." 5772 5950 W3004727452.pdf 24 57 separator 0.97109854 ¶ 5950 5952 W3004727452.pdf 24 58 bibliography 0.9978311 "Friedl, M. A., McIver, D. K., Hodges, J. C. F., Zhang, X. Y., Mu- choney, D., Strahler, A. H., Woodcock, C. E., Gopal, S., Schnei- der, A., Cooper, A., Baccini, A., Gao, F., and Schaaf, C.: Global land cover mapping from MODIS: algorithms and early results, Remote Sens. Environ., 83, 287–302, 2002." 5952 6260 W3004727452.pdf 24 59 separator 0.96567297 ¶ 6260 6262 W3004727452.pdf 24 60 bibliography 0.99793446 "Galanter, M., Levy, H., and Carmichael, G. R.: Impacts of biomass burning on tropospheric CO, NO x, and O 3, J. Geophys. Res.- Atmos., 105, 6633–6653, 2000." 6262 6423 W3004727452.pdf 24 61 separator 0.95623296 ¶ 6423 6425 W3004727452.pdf 24 62 bibliography 0.9976821 "Giglio, L., Descloitres, J., Justice, C. O., and Kaufman, Y. J.: An enhanced contextual fire detection algorithm for MODIS, Remote. Sens. Environ., 87, 273–282, doi:10.1016/S0034- 4257(03)00184-6, 2003a." 6425 6634 W3004727452.pdf 24 63 separator 0.9589598 ¶ 6634 6636 W3004727452.pdf 24 64 bibliography 0.9924931 "Giglio, L., Kendall, J. D., and Mack, R.: A multi-year active fire dataset for the tropics derived from the TRMM VIRS, Int. J. Remote Sens., 24, 4505–4525, www.atmos-chem-phys.net/10/11707/2010/ Atmos. Chem. Phys., 10, 11707– 11735, 2010" 6636 6879 W3004727452.pdf 24 0 paratext 0.9787546 533 0 3 W4390344170.pdf 1 1 separator 0.5797531 ¶ 3 5 W4390344170.pdf 1 2 paratext 0.64395607 ИЗВЕСТИЯ ВУЗОВ. ПРИКЛАДНАЯ ХИМИЯ И БИОТЕХНОЛОГИЯ 2023 Том 13 N 4 5 73 W4390344170.pdf 1 3 separator 0.92176473 ¶ 73 75 W4390344170.pdf 1 4 paratext 0.95529425 PROCEEDINGS OF UNIVERSITIES. APPLIED CHEMISTRY AND BIOTECHNOLOGY 2023 Vol. 13 No. 4 https://vuzbiochemi.elpub.ru/jour 75 195 W4390344170.pdf 1 5 text 0.9994697 "Abstract. Extremophile organisms can survive under extreme conditions through tolerance mechanisms. Such organisms include lichens, which are symbiotic associations of fungi and algae and/or cyanobacteria. Among other factors, the high stress tolerance of lichens can be attributed to their ability to synthesize a wide range of metabo - lites, including chemically diverse lipid compounds. Despite their obvious relevance, the biochemical mechanisms of stress tolerance in lichens that are mediated by changes in the lipid profile remain understudied. Peltigerous lichens constitute a separate division of lichens characterized by high growth rates and metabolic activity indices. Taking into account the temperate climate in which these lichens grow, it can be assumed that they may be highly sensitive to temperature fluctuations. These factors led to the choice of Peltigera canina, epigeic lichen, as the subject matter of this study. The present work examined stress-induced changes in the redox status of P. canina, as well as changes in its lipid composition at an elevated temperature (40 °С). The exposure of hydrated lichen thalli to an unfavorable temperature led to an increase in the level of hydrogen peroxide, phenoloxidase activity, and lipid peroxidation, which constitutes an important part of stress response in lichen. The stress-induced changes in the redox status of lichen thalli stimulated an increase in lipophilic antioxidant agents: a dramatic increase in the level of α-tocopherol and an increase in carotenoids, specifically β-carotene. Thus, the accumulation of lipophilic antioxidants constitutes an important part of the lipid-mediated stress response of P. canina to temperature elevation." 195 1960 W4390344170.pdf 1 6 separator 0.9689683 ¶ 1960 1962 W4390344170.pdf 1 7 text 0.5803373 Keywords: lichen, lipids, carotenoids, α-tocopherol, oxidative stress, temperature 1962 2046 W4390344170.pdf 1 8 bibliography 0.38276705 stress 2046 2053 W4390344170.pdf 1 9 separator 0.98873836 ¶ 2053 2055 W4390344170.pdf 1 10 text 0.98824775 "Funding. This work was partially performed within the framework of the state assignment of the FRC KazSC RAS (analysis of redox parameters), and with the financial support of the Russian Science Foundation, grant no. 22-14- 00362 (J.N. Valitova, analysis of lipid composition)." 2055 2339 W4390344170.pdf 1 11 separator 0.98841524 ¶ 2339 2341 W4390344170.pdf 1 12 bibliography 0.83663833 "For citation: Valitova J.N., Khabibrakhmanova V.R., Guryanov O.P., Uvaeva V.L., Khairullina A.F., Rakhmatullina D.F., et al. Changes in the lipid composition of Peltigera canina at an elevated temperature. Izvestiya Vuzov. Prikladnaya Khimiya i Biotekhnologiya =" 2341 2612 W4390344170.pdf 1 13 paratext 0.48933026 P 2612 2614 W4390344170.pdf 1 14 bibliography 0.5421391 roceedings of Universit 2614 2637 W4390344170.pdf 1 15 paratext 0.5025846 ies 2637 2640 W4390344170.pdf 1 16 bibliography 0.5081999 . 2640 2641 W4390344170.pdf 1 17 paratext 0.49435568 A 2641 2643 W4390344170.pdf 1 18 bibliography 0.48546028 pplied 2643 2649 W4390344170.pdf 1 19 paratext 0.48469815 2649 2650 W4390344170.pdf 1 20 bibliography 0.5337219 Chemistry and 2650 2663 W4390344170.pdf 1 21 paratext 0.6816399 Biotechnology. 2023;13(4): 532-544. 2663 2699 W4390344170.pdf 1 22 separator 0.54433143 ¶ 2700 2702 W4390344170.pdf 1 23 paratext 0.9746516 (In Russian). DOI: 10.21285/2227-2925-2023-13-4- 532-544 . EDN: UISMLE . 2702 2775 W4390344170.pdf 1 24 separator 0.9952529 ¶ 2775 2777 W4390344170.pdf 1 25 title 0.98648274 ВВЕДЕНИЕ 2777 2786 W4390344170.pdf 1 26 separator 0.99488723 ¶ 2786 2788 W4390344170.pdf 1 27 text 0.99944603 "Проблема стрессовой устойчивости живых орга - низмов является предметом пристального внимания ученых в течение многих лет. В связи с этим повышенный интерес исследователей вызывают экстремофилы – орга - низмы, способные выживать в экстремальных условиях посредством уникальных механизмов устойчивости. К таким организмам относятся и лишайники, которые представляют собой симбиотические ассоциации между грибами (микобионтами) и водорослями и/или циа - нобактериями (фотобионтами). Температурный стресс является достаточно обычным явлением для лишай - ников, произрастающих зачастую в неблагоприятных условиях. В настоящее время известно, что большинство лишайников в высушенном состоянии чрезвычайно устойчивы к высокотемпературному стрессу, тогда как гидратированные талломы обладают значительно большей чувствительностью к изменению температуры [1, 2]." 2788 3687 W4390344170.pdf 1 28 separator 0.865669 ¶ 3688 3690 W4390344170.pdf 1 29 text 0.99321604 "Интересной группой лишайников являются лишайники порядка Пельтигеровые, широко распространенные по всему миру и произрастающие в умеренном климате. Данные лишайники являются обособленным отделом лишайников и относятся к отдельной ветви лишайникового сообщества. Известно, что они отличаются высокими темпами роста и активным редокс-метаболизмом [3]." 3690 4058 W4390344170.pdf 1 30 separator 0.69784594 ¶ 4059 4061 W4390344170.pdf 1 31 text 0.99943954 "В связи с этим можно предположить, что пельтигеровые лишайники продемонстрируют выраженную реакцию к действию неблагоприятных температур. Одним из известных представителей пельтигеровых является эпи - гейный двухкомпонентный цианолишайник Peltigera canina , который был выбран в качестве объекта наших исследований. Известно, что важной составляющей стрессового ответа живого организма на воздей - ствие абиотических стрессовых факторов является увеличение образования активных форм кислорода (АФК) [4] и развитие окислительного стресса, который сопровождается перекисным окислением липидов и повреждением клеточных мембран. В связи с этим актуально изучение стресс-индуцированных изме - нений в липидном профиле лишайников, в том числе в содержании липофильных соединений, обладающих антиоксидантными свойствами. В настоящее время биохимические механизмы стрессовой устойчивости лишайников, опосредованные изменениями липидного профиля, изучены недостаточно полно. Целью настоящей работы было изучение изменений липидного состава лишайника P. canina при действии повышенной темпе - ратуры. Понимание биохимических основ липид-опо - средованных стрессовых ответов лишайников поможет более углубленно и детально разобраться в механизмах стрессовой устойчивости экстремофилов." 4061 5395 W4390344170.pdf 1 32 separator 0.99444205 ¶ 5395 5397 W4390344170.pdf 1 33 title 0.9933405 ЭКСПЕРИМЕНТАЛЬНАЯ ЧАСТЬ 5397 5421 W4390344170.pdf 1 34 separator 0.99582815 ¶ 5421 5423 W4390344170.pdf 1 35 text 0.9994392 "Объектом исследования служили талломы лишайника P. canina , собранного на территории Республики Татарстан в мае 2023 года. После сбора и предва - рительной очистки талломы лишайника высушивали при комнатной температуре. Высушенный материал помещали в морозильную камеру (минус 20 °C) на хранение до использования в экспериментах." 5423 5761 W4390344170.pdf 1 36 separator 0.99693906 ¶ 5761 5763 W4390344170.pdf 1 37 title 0.95240057 Стрессовая обработка лишайника Peltigera canina. 5763 5812 W4390344170.pdf 1 38 separator 0.99406517 ¶ 5813 5815 W4390344170.pdf 1 39 text 0.99844617 "Талломы лишайника, выложенные в один слой, гидрати - ровали в контейнерах на вискозных салфетках, увлаж - ненных дистиллированной водой, в течение двух суток при температуре 5 °С. Перед стрессовой обработкой контейнеры с гидратированными талломами оставляли на 2 ч при комнатной температуре, после чего их раскла - дывали по 1,0±0,1 г на диски фильтровальной бумаги, смоченной 1,5 мл дистиллированной воды, которые были уложены на чашки Петри. Для стрессовой обра - ботки чашки Петри с образцами закрывали, помещали в термостат ТСО-1/80 СПУ (Смоленское СКТБ СПУ, Россия) и оставляли при температуре 40 °C на 30 мин, 1 ч, 2 ч, 3 ч с целью изучения динамики образования" 5815 6512 W4390344170.pdf 1 0 bibliography 0.98952806 Andrian et al ., 2023 0 21 W4385507956.pdf 8 1 separator 0.96342754 ¶ 21 23 W4385507956.pdf 8 2 bibliography 0.9712071 "ID: 3863Rev. Multi. Saúde, v. 4, n. 364ROSENBERG, M. Society and the adolescent self image. Princeton: Princeton University Press, 1965 https://www.jstor.org/stable/j.ctt183pjjh" 23 205 W4385507956.pdf 8 3 separator 0.99062717 ¶ 205 207 W4385507956.pdf 8 4 bibliography 0.99663466 "SANTOS , Marcela Savegnago dos et al. Implicações da mastectomia na autoestima da mulher. Revista Eletrônica Acervo Saúde , Porto Velho, v . 29, jun 2019." 207 372 W4385507956.pdf 8 5 separator 0.98812014 ¶ 374 376 W4385507956.pdf 8 6 bibliography 0.9942403 "SANTOS , Cintia Barcala de Oliveira; SIVIERO , Ivana Maria Passini Sodré; PIETRAFESA , Gisele Acerra Biondo . Sexualidade da mulher acometida com o câncer de mama. Revista Interdisciplinar em Ciências da Saúde e Biológica , v. 4, n. 2, p. 15-25, 11 Nov 2020." 376 647 W4385507956.pdf 8 7 separator 0.9834634 ¶ 649 651 W4385507956.pdf 8 8 bibliography 0.99756664 "STUNKARD, A. J. et al. Use of the danish adoption register for the study of obesity and thinness. In: KETY , S. et al. (Ed.). The genetics of neurological and psychiatric disorders. New York: Raven Press, p. 115-120, 1983." 651 880 W4385507956.pdf 8 9 separator 0.9830669 ¶ 880 882 W4385507956.pdf 8 10 bibliography 0.99739945 "URBAN , Cicero et al. Cirurgia oncoplástica e reconstrutiva da mama: Reunião de Consenso da Sociedade Brasileira de Mastologia. Revista Brasileira de Mastologia , Rio de Janeiro, v. 25, n. 4, p. 118-24, 25 out 2015." 882 1110 W4385507956.pdf 8 11 separator 0.9849248 ¶ 1110 1112 W4385507956.pdf 8 12 bibliography 0.9979667 "VERENHITACH , Beatriz Daou et al. Câncer de mama e seus efeitos sobre a sexualidade: uma revisão sistemática sobre abordagem e tratamento. Femina, São Paulo, v. 42, n. 1, p. 3-10, jan/fev 2014." 1112 1317 W4385507956.pdf 8 0 paratext 0.9588279 "¶ ISSN: 2790–0088 Journal of Biomedical and Sustainable Healthcare Applications 1( 1)(2021) 23" 1 140 W3214994968.pdf 5 1 separator 0.988936 ¶ 141 143 W3214994968.pdf 5 2 text 0.99975145 "Scientific proof analysis adds to the pessimism, saying that ""health has a poor track history for embracing actually cutting technology."" What role might artificial intelligence play in this? Medicinal technology's main approach is to create linkages via trends depending on current information (datasets), and we can assume that the statistical technique existed at the heart of this procedure for a long period of time even before AI. However, utilizing three major scientific -statistical methods — the designed method, the databases technique, and the strategic decision method – AI might be much more successful in this area. They're all usable, but they're all better suitable for AI application in various ways. The ""Diagrammatical technique"" is based on the collection of known signs, which results in a historical record and a likely diagnosis by integrating signs into one image. The drawbacks of such a strategy are apparent. They are the need to enter a large amount of data on various symptoms, their features, combinations, related illnesses, and so on in order to get a reliable result. Furthermore, because of healthcare professional's intermediate function, such a strategy is restricted - the AI Algorithms can't ""query"" anything other than the data given by the clinical employee, and can't get any data about the specific patient – a 100 percent ""ma chines"" and predictable method." 144 1584 W3214994968.pdf 5 3 separator 0.8791939 ¶ 1586 1588 W3214994968.pdf 5 4 text 0.9997536 "It may, nevertheless, be helpful in some situations, such as recording emergency procedures for clinicians to follow, individual questioning, or providing medical recommendations in the chemical re gion. The ""Data approach"" is centered on the personality, personal self, and in analytical principles. When AI has to understand how to detect interconnections and trends, it employs a set of techniques that are intended to determine how illness or mixes o f disorders, visual aspects, and other factors emerge. Such technologies are typically operational, for example, in the relevant problem of COVID -19 diagnoses based on coughed sounds. Although such information computing technologies have progressed, they c an be used in all situations due to a number of concerns, including elevated expenses and duration expended gathering and manufacturing huge datasets; difficulties comparing old and new information; cultural variations in gathered information; the potentia l of clinical exclusions in certain kinds of infections; and a lack of specifics and incapability to replace the responsibility of the doctors. Certainly, such a technique may be accomplished in practice, but the breadth of such deployment should not be ov erstated." 1588 2855 W3214994968.pdf 5 5 separator 0.9685724 ¶ 2857 2859 W3214994968.pdf 5 6 text 0.9969603 "The ""strategic decision technique"" is based on statistical methods for taking decisions under ambiguity, which include previous experiences, manifestation, probability, and consequences. Despite its simplicity, such a method has certain difficult ies about getting acceptable estimations of probability and benefits for a specific study. Whereas methods like sensitive assessment may assist to identify which possible errors are insignificant, a limitation of sufficient information frequently induces f alse approximations of the issue, lowering trust in the study' conclusion. For example, such a method may lead to a scenario in which many signs are mistaken for a singular illness (when they are really a composite resulting to one), or vise - versa. Furth ermore, the quantitative analytic depiction of the strategic decision procedure clearly varies from those of a genuine personal clinician, which may cause the patients to be confused. As a result, each method is appropriate, but not ubiquitous. Moreover, c onsidering the fairly lengthy history of AI, we must acknowledge that it is just the beginning for the technologies in overall and its application in medical in specific. ""While there are broad concerns about what is genuine in AI in medical presently,"" ba sed to new study, ""this analysis examined at 23 programs in use now and offers example reports of 14 programs that are currently being used. These examples show how AI may help individuals control their own treatment, as well as computerized symptoms detec tors and e -triage AI systems, digital assistants that can do jobs in clinics, and a prosthetic pancreatic to assist diabetic individuals."" According to predictions , there will be three major stages of AI in medical scalability: 1. A low technological applicat ion layer in which AI will help with administration chores that are repetitious. At this time, AI technologies will allow actual image AI application in ophthalmic and radiography, as well as reducing the associated burden (not the primary one) of clinical personnel at all stages. 2. AI-assisted residence healthcare stage, in which AI -assisted distant tracking and alarming visible guidance on the foundation of AI technologies will enable a shift in specialized health models towards distant surveillance and det ecting visible help. Furthermore, breakthroughs will be made in AI's application in cancer care, cardiothoracic, and neuroscience, where it is currently demonstrating its first aspects of deployment with wider digital supply chain configurations (by machin e learning, NLP, and accessibility) and organizational growth in conjunction with established innovations." 2859 5609 W3214994968.pdf 5 7 separator 0.53553236 ¶ 5611 5613 W3214994968.pdf 5 8 text 0.99928856 "3. Medical studies and judgement support level, in which AI innovations will be integrated into clinical information systems and entrenched in every ste p of the care systems, from teaching and understanding the medical studies and diagnosis, as well as healthcare improvement and overall care assessment." 5613 5925 W3214994968.pdf 5 9 separator 0.9811865 ¶ 5927 5929 W3214994968.pdf 5 10 text 0.99974877 "As a result, we are still a long way from widespread AI adoption in medical, and now is the time to con sider what kinds of problems it may bring. Are we prepared to deal with them, and if not, what approach should we use to reduce the dangers? Moreover, the fundamental problem stems from the fact that we're talking about fundamental changes in medical, public health concerns, the clash among formal and informal concerns, values and ethical, innovation, and mankind. We have no plans to go extensively into every aspect of AI application in health, and it will be the focus of our future study." 5929 6540 W3214994968.pdf 5 11 separator 0.91544247 ¶ 6541 6543 W3214994968.pdf 5 12 text 0.9949902 So, let's go to w ork on the research. 6543 6582 W3214994968.pdf 5 13 separator 0.97767043 "¶ ¶" 6584 6594 W3214994968.pdf 5 14 title 0.9911817 V. DISCUSSION 6594 6608 W3214994968.pdf 5 15 separator 0.996601 ¶ 6610 6612 W3214994968.pdf 5 16 text 0.9997409 "The deployment of machine -learning technologies and techniques, or intelligent systems, to replicate mental abilities in the assessment, display, and interpretation of complicated healthcare and health data is known as artificial intelligence in medicine. AI is the capacity of computational models to make educated guesses based only on data input. AI technology is distinguished from traditional healthcare solutions by its ability to take data, evaluate it, and offer a well -defined" 6612 7109 W3214994968.pdf 5 0 paratext 0.8211668 ¶ _________ 1 12 W2099065338.pdf 0 1 separator 0.9870007 ¶ 13 15 W2099065338.pdf 0 2 text 0.8112033 "Alexa Smith-Osborne, Ph.D. is assistant professor of social work, University of Texas at Arlington. Support for the preparation of this article was given by a University of Te xas Arlington research enhancement grant and a grant from the Hogg Foundation for Mental Health." 15 295 W2099065338.pdf 0 3 separator 0.9551867 ¶ 297 299 W2099065338.pdf 0 4 paratext 0.9880725 Copyright © 2012 Advances in Social Work Vol. 13 No. 1 (Spring 2012), 34-50 300 376 W2099065338.pdf 0 5 separator 0.9873518 ¶ 377 379 W2099065338.pdf 0 6 title 0.9905841 "Supporting Resilience in the Academic Setting for Student Soldiers and Veterans as an Aspect of Community Reintegration:" 380 504 W2099065338.pdf 0 7 separator 0.520234 506 507 W2099065338.pdf 0 8 title 0.93663245 ¶ The Design of the Student Veteran Project Study 507 557 W2099065338.pdf 0 9 separator 0.98461163 ¶ 558 560 W2099065338.pdf 0 10 contact 0.845913 Alexa M. Smith-Osborne 560 583 W2099065338.pdf 0 11 separator 0.9953927 ¶ 584 586 W2099065338.pdf 0 12 text 0.9991738 "Abstract: The Post 9/11 GI Bill is leading an in creasing proportion of wounded warriors to enter universities. This paper describes the design and development of an adapted supported education intervention for veterans. The intervention trial was one of two projects which grew out of a participatory action research process aimed at supporting reintegration of returning veterans into the civilian community. This intervention is being tested in a foundation-funded randomized controlled trial in a large southwestern university, with participation now extended to student-veterans at colleges around the country. Some protective mechanisms which w ere found in theory and in prior research were also supported in early results. SEd int ervention was associated with the protective mechanisms of support network density, hi gher mood, and resilience. Practitioners may benefit from the lessons learned in the development of this supported education intervention trial when considering implemen tation of this complementary intervention for veterans reintegrating into civilian life." 586 1705 W2099065338.pdf 0 13 separator 0.99243486 ¶ 1706 1708 W2099065338.pdf 0 14 text 0.5419237 Keywords: Veterans, resilience, supported educati 1708 1759 W2099065338.pdf 0 15 paratext 0.3031392 on 1759 1762 W2099065338.pdf 0 16 text 0.46152413 , psychiatric rehabilitation, GI 1762 1794 W2099065338.pdf 0 17 paratext 0.4258447 Bill 1794 1799 W2099065338.pdf 0 18 separator 0.99671674 ¶ 1800 1802 W2099065338.pdf 0 19 title 0.99017376 INTRODUCTION 1802 1815 W2099065338.pdf 0 20 separator 0.995061 ¶ 1816 1818 W2099065338.pdf 0 21 text 0.9991817 "The Department of Defense (DoD) has initia ted innovative efforts to support mission readiness and prevent mental health problem s among troops in current conflicts. These efforts use two theoretical frameworks, r esilience and positive psyc hology, which show goodness of fit with military emphasis on pro active preparedness a nd adaptive fitness and training (e.g., Britt, Adler, & Bartone, 2001; Castro, 2008; Cornum, Matthews, & Seligman, 2011; Mojica, 2010; Office of the U.S. Army Surgeon General, 2003, 2008, 2009; Orsingher, Lopez, & Rinehart, 2008)." 1818 2396 W2099065338.pdf 0 22 separator 0.87611127 ¶ 2397 2399 W2099065338.pdf 0 23 text 0.99948335 "Community institutions which serve military members and families, taking over educational, health, and social service delivery from DoD institutions when military service is done, may enhance continuity of car e and community reintegration by adopting service models consistent with these theore tical frameworks. Choice of theory has important implications for measurement (Luthar, 1993, Luthar & Cushing, 1999), goodness of fit of intervention with target group (Greene, 2007; Holter, Mowbray, Bellamy, MacFarlane, & Dukarski, 2004; Luth ar, Sawyer, & Brown, 2006), and fidelity of intervention implementation (Bond, Evan s, Salyers, Williams, & Kim, 2000; Borrelli et al., 2005). Academic settings are one impor tant community ins titution for returning service members, as pursuing higher education has been identified as a key goal for" 2399 3265 W2099065338.pdf 0 0 title 0.89272106 B. anthracis Infection 0 22 W100478810.pdf 7 1 separator 0.95820653 ¶ 22 24 W100478810.pdf 7 2 text 0.99720174 "and nonsurvivors of this newly described form of infec- tion. Although duration of symptoms and time to seeking hospital care did not differ between survivors and nonsur-vivors, the severity of illness did. Most survivors reported localized symptoms related to the injection site, and none required vasopressor therapy or mechanical ventilation. In contrast, most nonsurvivors had generalized symptoms and evidence of sepsis, which required both vasopressor support and mechanical ventilation. Nonsurvivors also had lower systolic blood pressures and Glasgow coma scores; higher respiratory rates; worsened base deficits; higher levels of hemoglobin (consistent with hemoconcentration) and C-reactive protein; higher international normalized ratio; and lower sodium and albumin levels and platelet counts. During hospitalization, all nonsurvivors required vasopressor and ICU support, whereas only 3 and 7 survi-vors, respectively, required these. SOFA scores were sub-stantially higher in nonsurvivors than survivors. Thus, as-sessing the need for aggressive cardiopulmonary support or determining a score like SOFA for patients with in-jectional anthrax can help identify those for whom prog-nosis is particularly poor and more aggressive therapy is needed.Possibly consistent with prior analysis showing an association between excessive alcohol use and risk for B. anthracis infection in PWID, we found a higher incidence of excessive alcohol use among nonsurvivors than survi-vors (6). Increased bilirubin and decreased albumin levels in nonsurvivors might in part have reflected preexisting alcoholic liver disease. Although age did not differ sig-nificantly between survivors and nonsurvivors, the latter tended to be older, a finding consistent with analysis of in-halational B. anthracis infection ( 14)." 24 1854 W100478810.pdf 7 3 separator 0.9927205 ¶ 1854 1856 W100478810.pdf 7 4 title 0.6937403 Differences in outcome 1856 1880 W100478810.pdf 7 5 text 0.76094276 between survivors and non- 1880 1906 W100478810.pdf 7 6 separator 0.5525547 ¶ 1906 1908 W100478810.pdf 7 7 text 0.9996965 survivors did not appear related to variation in treatment. All patients received antibacterial drugs from the time they sought care, and the types and numbers of antibacterial drugs administered did not differ. Also, the proportion of patients who had >1 surgeries and the time from admission to initial surgery did not differ. Finally, similar proportions of survivors and nonsurvivors received anthrax immune globulin, and the median time to treatment for these groups did not differ. 1908 2396 W100478810.pdf 7 8 separator 0.9413799 ¶ 2396 2398 W100478810.pdf 7 9 text 0.99560547 "The most common skin and limb findings were local - ized edema, pain, and erythema. Although these findings are consistent with soft tissue infection, their presence did" 2398 2570 W100478810.pdf 7 10 separator 0.98189294 ¶ 2571 2573 W100478810.pdf 7 11 paratext 0.9861996 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 20, No. 9, September 2014 1459 2574 2659 W100478810.pdf 7 12 separator 0.9939172 ¶ 2660 2662 W100478810.pdf 7 13 title 0.98165524 Table 3. Initial administration of a ntibacterial drug s to persons who inject drug s and had Bacillus anthracis Infection, Scotland, UK, 2662 2801 W100478810.pdf 7 14 separator 0.9413973 ¶ 2802 2804 W100478810.pdf 7 15 table 0.78265655 2009 –2010* 2804 2816 W100478810.pdf 7 16 separator 0.56836814 ¶ 2818 2820 W100478810.pdf 7 17 table 0.9894151 "Patient no. † CLI CIP BPC FLUX MTZ CRO GEN VAN MEM TZP AMC AMX Survivor, n = 16‡ 14 (88) 12 (75) 11 (69) 11 (69) 8 (50) 1 (6) 0 2 (13) 1 (6) 0 1 (6) 0 1 + + – – + – – + – – – – 2 + – – + + – – – – – – – 3 – – + + – – – – – – + – 4 + + + + + – – – – – – – 5 + + + – + – – – – – – – 6 + + + – – – – – – – – – 7 + + + + + – – – – – – – 8 + + + + – – – – – – – – 9 + + + + + – – – – – – – 10 + + + + – – – – – – – – 11 – – – + – – – – – – – – 12 + + + + + – – – – – – – 13 + – – – – – – – + – – – 14 + + + + – – – – – – – – 15 + + + + + + – – – – – – 16 + + – – – – – + – – – – Nonsurvivor , n = 11 ‡ 7 (64) 6 (55) 5 (45) 5 (45) 6 (55) 4 (36) 3 (27) 1 (9) 1 (9) 1 (9) 0 1 (9) 1 – – – – + + – – – – – – 2 – – – – – + – – – – – – 3 + + + + + – + – – – – – 4 + + + + + – – – – – – – 5 – – – + – – – – – – – – 6 + + + + + – – – – – – – 7 + + + – – – – – – – – – 8 + – + + – – + – – – – – 9 + + – – + + + + + + – – 10 + + – – + + – – – – – – 11 – – – – – – – – – – – + Total , n = 27 21 (78) 18 (67) 16 (59) 16 (59) 14 (52) 5 (19) 3 (11) 3 (11) 2 (7) 1 (4) 1 (4) 1 (4)" 2820 4023 W100478810.pdf 7 18 separator 0.8093293 ¶ 4024 4026 W100478810.pdf 7 19 table 0.8269542 "*CLI, clindamycin; CIP, ciprofloxacin; BPC, benzylpenicillin (penicillin G); FLUX, flucloxacillin; MTZ, metronidazole; CRO, ce ftriaxone; GEN, gentamicin ; VAN, vancomycin; MEM, meropenem; TZP, piperacillin/tazobactam; AMC, amoxicillin/clavulanic acid; AMX, amoxicillin; +, antibacterial drug administered; –, antibacterial drug not administered." 4026 4379 W100478810.pdf 7 20 separator 0.6888667 ¶ 4381 4384 W100478810.pdf 7 21 table 0.65448844 †Patients for whom data were available are numbered in the order in which they sought care during 4384 4481 W100478810.pdf 7 22 text 0.49275327 the 4481 4485 W100478810.pdf 7 23 table 0.73055303 "outbreak. ‡No. (%) patients receiving an antibacterial drug ." 4485 4551 W100478810.pdf 7 24 separator 0.98801947 ¶ 4553 4555 W100478810.pdf 7 0 paratext 0.9862685 237 Bull World Health Organ 2020;98:237–238 | doi: http://dx.doi.org/10.2471/BLT.20.030420News 0 94 W4232597083.pdf 0 1 separator 0.9943748 ¶ 94 96 W4232597083.pdf 0 2 text 0.95915926 "Q: You started out in electrical engineer - ing. How did you get from there to work- ing on artificial intelligence (AI)?" 96 222 W4232597083.pdf 0 3 separator 0.9617335 ¶ 222 224 W4232597083.pdf 0 4 text 0.99938595 "A: It started with a fascination for computers. I still remember my first computer class. The teacher came to class dressed like a magician, with a pointed hat and a purple cape, and he said, ‘computing is like magic’ . I be- lieved it then and still do. I studied and graduated with degrees in computer science and electrical engineering, so I was trained in working with software and hardware as a whole system and in real-world applications. I think this system perspective has helped shape my research interests and directions throughout my career." 224 818 W4232597083.pdf 0 5 separator 0.99366736 ¶ 818 820 W4232597083.pdf 0 6 text 0.88059473 "Q: What was your first contact with artificial intelligence?" 820 884 W4232597083.pdf 0 7 separator 0.82253027 ¶ 884 886 W4232597083.pdf 0 8 text 0.9994355 "A: I worked on a research project called “Murmur Clinic: An Auscultation Expert System” – the objective was to build a computer program that would diagnose the symptoms and sound patterns related to different heart con- ditions. It was really exciting to see the system predictions actually matching the diagnoses of the doctors!" 886 1239 W4232597083.pdf 0 9 separator 0.9948778 ¶ 1239 1241 W4232597083.pdf 0 10 text 0.7839739 "Q: What is the main focus of your re - search?" 1241 1290 W4232597083.pdf 0 11 separator 0.8838142 ¶ 1290 1292 W4232597083.pdf 0 12 text 0.99952525 "A: Developing human-aware AI that is capable of dealing with real-life problems. Essentially, designing AI in- novations that work for, with and along- side humans. To do this, the AI needs to be able to make good decisions despite incomplete information, evolving condi- tions and limited resources." 1292 1611 W4232597083.pdf 0 13 separator 0.99444675 ¶ 1611 1613 W4232597083.pdf 0 14 text 0.81596285 Q: Can you give some examples of AI ap 1613 1652 W4232597083.pdf 0 15 title 0.49999326 1652 1653 W4232597083.pdf 0 16 text 0.53336895 - 1653 1654 W4232597083.pdf 0 17 title 0.51197076 1654 1655 W4232597083.pdf 0 18 text 0.55556697 ¶ 1655 1656 W4232597083.pdf 0 19 title 0.55743736 1656 1657 W4232597083.pdf 0 20 text 0.73964536 plications you have worked on? 1657 1687 W4232597083.pdf 0 21 separator 0.9615488 ¶ 1687 1689 W4232597083.pdf 0 22 text 0.99619275 "A: Specific applications include ef- fective management of coronary artery disease patients with stroke, follow-up strategies for colorectal cancer patients after surgery, interpretation of intensive care unit (ICU) data for decision sup- port, etc. A lot of my work has been on neurocognitive issues, with applications ranging from intelligent image-based diagnosis in strokes and brain injuries, diagnosis and staging for dementia, and personalized assistive care for older peo-ple with neurodegenerative disorders. " 1689 2240 W4232597083.pdf 0 23 separator 0.55787116 ¶ 2240 2241 W4232597083.pdf 0 24 text 0.99900377 "Currently, I am also working on future research directions of biomedical and health informatics, and ethics and gov- ernance, and regulatory considerations for AI in health in general." 2241 2437 W4232597083.pdf 0 25 separator 0.8449365 ¶ 2437 2439 W4232597083.pdf 0 26 text 0.9792306 "“We [need] relevant regulatory and governance guidelines and protocols to enhance the benefits and minimize the potential harm of these technologies and systems.”" 2439 2626 W4232597083.pdf 0 27 separator 0.9950032 ¶ 2626 2628 W4232597083.pdf 0 28 text 0.75412405 Q: 2628 2631 W4232597083.pdf 0 29 title 0.50894266 What 2631 2636 W4232597083.pdf 0 30 text 0.6660955 are the main AI-related ethics, 2636 2668 W4232597083.pdf 0 31 title 0.51994824 2669 2670 W4232597083.pdf 0 32 text 0.8119958 ¶ governance, and regulatory concerns? 2670 2708 W4232597083.pdf 0 33 separator 0.9530289 ¶ 2708 2710 W4232597083.pdf 0 34 text 0.9995286 "A: They cover a broad range of is- sues reflecting the extraordinarily broad application of AI in the contemporary health space. Just to focus on clinical application, AI supports diagnosis, treatment, and prognosis management through data analytics and predictive modelling for disease screening, stag-ing, progression and risk stratification, individualized treatment and care plans, optimization of workflow processes and cost-effectiveness analyses. AI is also es- sential in scientific discovery and experi- mentation, especially in drug discovery and clinical trials, as well as in disease modelling and surveillance, and health policy analysis and design." 2710 3415 W4232597083.pdf 0 35 separator 0.8313116 ¶ 3415 3417 W4232597083.pdf 0 36 text 0.99925554 "In all of these applications, digital health and AI brings tremendous ben- efits, but at the same time sometimes unexpected, and even harmful effects." 3417 3576 W4232597083.pdf 0 37 separator 0.9032613 ¶ 3577 3579 W4232597083.pdf 0 38 text 0.99941 "As we learn more about the power and the limitations of digital health and AI in medicine, we need to catch up with improving the development and appli- cation approaches and processes. We also need to start establishing relevant regulatory and governance guidelines and protocols to enhance the benefits and minimize the potential harm of these technologies and systems." 3579 3977 W4232597083.pdf 0 39 separator 0.8505181 ¶ 3977 3979 W4232597083.pdf 0 40 text 0.9995249 "The main danger and the greatest harms are brought about by poorly de- signed, hastily developed, inadequately tested, and/or inappropriately used digi- tal and AI health systems. Unfortunately, we have heard many horror stories, which result from such situations. So much needs to be done to improve the design, development, implementation, use, and regulation of digital and AI health system applications." 3979 4415 W4232597083.pdf 0 41 title 0.9785124 Tze-Yun Leong: the need for intelligent regulation 4415 4465 W4232597083.pdf 0 42 separator 0.9932049 ¶ 4465 4467 W4232597083.pdf 0 43 text 0.9989148 Tze-Yun Leong talks to Gary Humphreys about the challenges faced in realizing the potential of digital health. 4467 4578 W4232597083.pdf 0 44 separator 0.96809727 ¶ 4578 4580 W4232597083.pdf 0 45 text 0.99825513 "Tze-Yun Leong is Director of AI Technology at AI Singapore, a national programme on Artificial Intelligence and Professor of Practice of Computer Science at the School of Computing, National University of Singapore. Author of over 150 international peer- reviewed publications on Artificial Intelligence (AI), she is currently focused on designing and operationalizing a series of multidisciplinary research, innovation, and education programmes that harness the power of AI to address the AI Grand Challenges – complex, national and global issues in health, education, and other domains. A member of the World Health Organization (WHO) Expert Group on Ethics and Governance of Artificial Intelligence in Health, she is also a Fellow of the American College of Medical Informatics, and a Founding Fellow of the International Academy of Health Sciences Informatics. Tze-Yun received her Bachelor (1987), Master (1991) and Doctoral (1994) degrees in Electrical Engineering and Computer Science from the Massachusetts Institute of Technology, in the United States of America.Courtesy of Tze-Yun Leong" 4580 5725 W4232597083.pdf 0 46 separator 0.9751699 ¶ 5725 5727 W4232597083.pdf 0 47 contact 0.6390113 Tze-Yun Leong 5727 5741 W4232597083.pdf 0 48 separator 0.994856 ¶ 5741 5743 W4232597083.pdf 0 0 title 0.9923393 Prediction ofmortality using baseline, peak and delta-RSI 0 57 W2803275897.pdf 6 1 separator 0.99373376 ¶ 57 59 W2803275897.pdf 6 2 text 0.99906754 "Using univariate logistic regression models, wefound that longitudinal assessments ofRSI were informative, whereas baseline assessments were not. Mean delta-RSI scores were highly predictive ofmortality (non-survivors: 33.6±5.6, survivors: 5.6±33.6, p<0.0001), aswere peak RSIscores (non-survivors: 53.2±13.2, survivors: 18.9±17.6, p<0.0001) (Table 5).However, baseline RSIscores were notpredictive ofmortality (non-survivors: 19.6±8.8, survivors: 13.3 ±14.3, p=0.22). Adding RSI-CT scores tothelogistic regression models improved thepredic- tivepower ofdelta-RSI butnotpeak RSI(Table 6).Delta-RSI using only RSI-CXR scores had good discrimination (area under theROC curve: 0.92) butthisdiscrimination improved with theaddition ofRSI-CT scores (area under theROC curve: 0.97)." 59 852 W2803275897.pdf 6 3 separator 0.99687135 ¶ 852 854 W2803275897.pdf 6 4 title 0.99075663 Reliability ofRSI between readers 854 888 W2803275897.pdf 6 5 separator 0.9948236 ¶ 888 890 W2803275897.pdf 6 6 text 0.9991851 "Reliability between readers wasexcellent forallRSIscores (ICC: 0.99). Table 7shows thedis- tribution ofradiologic patterns inCTand CXR asscored byeach reader. Weincluded allTable 2.Baseline characteris tics by30-day survival status." 890 1125 W2803275897.pdf 6 7 separator 0.99319667 ¶ 1125 1127 W2803275897.pdf 6 8 table 0.98106974 "Variable Survivor s(n=54) Non-Su rvivors (n=9) p-valuea Age (years, mean±SD) 52±15 59±14 0.17 Gender (%female) 27(50%) 1(11.1%) 0.04 Race(n,%U Non-Hisp anic White 39(72.2%) 8(88.9%) 1.00 Asian 4(7.4%) 1(11.1%) Black 5(9.3%) 0 Hispanic 5(9.3%) 0 Middle Eastern 1(1.9%) 0 dnrelyign CsaygCnanci (n,%U 0.10 Acute lymphocy ticleukemia 13(24%) 0(0.0%) Acute myelogen ousleukemia 14(26%) 7(77.8%) Chronic lymphocytic leukemia 4(7.4%) 1(11.1%) Chronic myelogenous leukemia 7(13.0%) 0(0.0%) Myelodysp lastic syndrome 1(1.9%) 0(0.0%) Hodgkin's lymphoma 1(1.9%) 1(11.1%) Non-Hod gkin's lymphoma 8(14.8%) 0(0.0%) Multiple myeloma 3(5.6%) 0(0.0%) Ovarian cancer 2(3.7%) 0(0.0%) T-cell prolymphoc yticleukemia 1(1.9%) 0(0.0%) tanceluoaofuaoogseLTpRS(n,%Ub0.38 Active 14(25.9%) 1(11.1%) Remission 8(14.8%) 0(0.0%) Refractor y 20(37%) 4(44.4%) Relapse 12(22.2%) 4(44.4%) Cytotoxic chemothera pywithin 30Days (n,%) 34(64.2%) 6(75%) 0.70 Lower respiratory tract infection, LRI aFisher's exact testforcategori caldata and Student's t-test forcontinuous data bActive =undergoing initial treatment forcancer; remission =disease-free atthetime ofenrollme ntforatleast 6months; relapse =disease occurring after remission; refractory =notreceiving initial treatment forcancer and never having achieved remission." 1127 2474 W2803275897.pdf 6 9 separator 0.9652735 ¶ 2474 2476 W2803275897.pdf 6 10 paratext 0.9620821 https://do i.org/10.1371/j ournal.pone .0197418.t002 2476 2529 W2803275897.pdf 6 11 separator 0.95629275 ¶ 2529 2531 W2803275897.pdf 6 12 paratext 0.5892427 Radio 2531 2537 W2803275897.pdf 6 13 title 0.7245441 log icprogression inpneumon iapredicts mortality 2537 2585 W2803275897.pdf 6 14 separator 0.56817317 ¶ 2585 2587 W2803275897.pdf 6 15 paratext 0.9832441 PLOS ONE |https://doi.or g/10.137 1/journal.po ne.01974 18 May 17,2018 7/18 2587 2663 W2803275897.pdf 6 0 text 0.9997656 "Ueber das Radialisphänomen.Von Dr. 1h. tioffa, städtischer Kinderarzt in Barmen.Die Prüfung der mechanischen Uebererregbarkeit der peripheri-schen Nerven zur Feststellung der kindlichen Tetanie(Spasmo- philie) erfolgt in der Praxis fast ausschließlich durch Bekiopten derStämme des N. facialis (Chvostek) und des N. peroneus (Lust).Esistbekannt und inder kinderarztlichcnLiteraturoft genug betont, daß die mechanische Uebererregbarkeit sämtliche Nerven-stämme der Peripherie betrifft, wenn auch nicht immer alle gleich-zeitig und in gleicher Stärke.Das Lustsche Peroneusphänomen hat sich darum so schnellin der kinderirztlichen Praxis eingeführt, weil es als Symptom derSpasmophilie entschieden konstanter istalsdasFazialisphänornen (Lust fand positives Peroneusphänomen bei Kindern mit manifesterTetanie oder kathodisçher Uebererregbarkeit in 97,4 0/o positiv, gegen-über 43,4 /o positivem Fazialisphänomen am gleichen Material) und weil seine Feststellung vom Verhalten des Kindes weit uiiabhängigeristals das Fazialisphänomen, dessen Beobachtung durch jede Be-wegung der mimischen Muskulatur gestört wird.Angaben über die Prüfung der mechanischen Erregbarkeit ananderen Nervenstämmen finden sich nur sehrspärlichund sind meist recht allgemein gehalten (vgl. die neueste ausführliche Mono-graphie von Asehenheim, Uebererregbarkeit im Kindesalter, mitbesonderer Berücksichtigung der kindlichen Tetanie (Erg. d. Inn. M.Bd. 17 1919).Nur Ibrahim erwähnt im Feershcn Lehrbuchder Kinderheilkunde (VI. Aufl. 1920 S. 488), daß er ,,öfter ein sehrdeutlichesRadialis- oder Peroneusphänonien auslösen konnte hei Beklopfen der betreffendenReizstellen am Oberarm und Fibula-köpfchen"".Ein schwerer Fall von Spasmophilie, den iCh im Jahr 1919 im Säuglingsheim beobachten konnte, gab Anlaß zur genaueren Er-forschung des Radial is ph än om ens. Dies Phänomen besteht, kurz gesagt, in folgender Erscheinung: Beklopfen des Stammes desNervus radialis an der Außenseite des Oberarms, und zwar an derUmschlagsstelle des Nerven, etwas unterhalb der Mitte des Ober-armes, löst eine blitzartige radiale Adduktion (Beugung) des Vorder.arms und Dorsalflexion der Hand aus. Bei höheren Graden von Uebererregbarkeit läßt sich diese Bewegung durch Beklopfen desOberarms von der Ansatzstelle des Deltamuskels an nach abwärtslängs des ganzen Sulcusradialis bzw. des Septum intermuscularelaterale bis zum Epicondylus lateralis des Oberarms hin auslösen.In den weniger hochgradigen Fällen bedarf es einer genauerenLokalisierung desReizesauf dieStelle, an welcher der Nervas radialis sich um die Außenkante des Oberarmknochens herumsclilägt.Man gibt dabei dem Arm des Kindes zweckmäßig eine Lagerungderart, daß der pronierte, im Ellenbogen leicht flektierte Vorder- arm auf dem linken Arm des Untersuchers oder auf einer passen-den Unterlage aufruht, ähnlich wie es Lust für den Unterschenkelbei Prüfung des Peroneusphänomens vorschreibt. Wichtig istes, den Klopfschlag gegen den Sulcus radialis bzw. das Septum inter.musculare laterale auszuführen und weder den Musc. biceps nochden Triceps oder den Muskelbauch des Brachioradialis zu beklopfen,da sonst Täuschungen durch vermehrte Muskele rregbark eiauftreten könnten, während es uns doch auf Erregbarkeitsprüfungdes Nervenstamines ankommt.Ueber die praktische Brauchbarkeit des Radialisphänoinens fürdieErkennung der Spasmophilie lehrenunsereErfahrungenan Säuglingen Folgendes.Im allgemeinen gehen Peroneus- und Ra-dialisphänoxnen durchaus parallel, invereinzeltenFällenfehlt das Radialisphänomen bei positivem Fazialis- und Peroneusphänomen, nurin 2 Fällen war Radialis + und Peroneus --. Bemerkenswert ist derWechsel der Erscheinungen im Verlauf einzelner Fälle: an manchenTagen wird das eine oder andere Phänomen negativ oder positiv;am konstantesten fanden wir das Peroneusphänomen, danach dasRadialisphänomen; dem stärksten Wechsel unterliegt das Fazialis. phänomen nach Tageszeiten wie Tagen. Wir prüfen jetzt grund-sätzlich in jedem Falle Chvostek, Radialis- und Peroneusphänomcn.Für die Erforschung der Spasmophilie scheint mir diese nur wenigzt!itraubende Erweiterting des Status jedenfalls zweckmäßig.Für den Wechsel der Erscheinungen nur ein Beispiel.Christel L.,1/2 Jahr alt.Manifeste Spasmophilie, Karpopedal-spasmen, Laryngospasmus, am 2ó. Xl. 1919 Fazialis wegen Schreiens nicht zu prüfen, Radjahs und Peroneus +, am 27. XI. 1919 Radtalisund Peroneus +, KOeZ bei 1,2 MA., am 28. Xl. 1919 Radialis undPeroneus -, Trousseau +, am 1. XII. 1919 Fazialis und Peroneus +, Radialis --, am 3. 12. 1919 Fazialis vorm. -, nachm. -j-, PeroneusundRadialis +,5. Xli. 1919alle3Phänomene +,.i. Xli. 1919Peroneus und untererFazialis-f,Radialis--,17. XII 1919 alle 3 Phänomene + 1. XII. 1919 Fazialis --, 23. XII. 1919 Fazialts -j-, Peroneus -, Radialis -.Bemerkenswert scheint mir das Verhalten der normalen ReflexebeiSpasmophilie.In mehreren Fällen hochgradiger spasmophilerUeberertegbarkeitfandenwir einSchwächerwerden desBaucl-decken- und Krernasterreflexes, in einem Falle auch Verschwindendes Patellarsehnen- und Achillesreflexes. Mit dem Rückgang derspasmophilen Uebererrcgbarkeit kamen die normalen Reflexe allmählichwieder zum Vorschein und verschwanden wieder bei erneutem An.stieg der tetanischen Uebererregbarkeit.Etwas Aehnliches beobachten wir ja bei den postdiphtlieri-sdhen Lähmungen (Gött, M. m. W . 1918 S. 669). Schon vor dem Auftreten der Lähmungen wird das Fazialisphänotnen positiv,die Sehnenreflexe verschwinden. ICh konnteinsämtlichen Fallenpostdiphtherischer Lähmung, die ichim letzten Jahr beobachtete, feststellen, daß mit dem Fazialisphänomen auch das LustsChe; Pero-neusphänomen und dasRadialisphänomenpositivwurdeh.Siebleiben auch positiv bei bestehender Lähmung und überdauern so-gar die Lähmungen geraume Zeit.Wir kommen damit zur Frage der Bewertung unserer Phänomenebei älteren Kindern.Ich bin mit 1K I ei n s e h m i d t (diese Wochen-schrift 1918 Nr. 43 S. 1017) der Ansicht, daß das Fazialisphänomeiiauch beim älterenKind pathologische Bedeutung besitzt, insofern es - abgesehen von den Fällen postinfektiöser Schädigung des Nervensystems - für eine angeborene funktionelle Minderwertig-keit des Nervensystems spricht. Ich sehe in dem positiven Fazialis- phänomen ein objektives Zeichen der kindlichen Neuropathie, undzwar vor allem auf Grund meiner über Jahre dauernden BeobaCh-tung sehr zahlreiCher Kinder in der Privatpraxis. Hier nun erweistsichdie Ergänzung der Beobachtung durch das Radialisphänomeiials von ganz besonderem Werte. Ich prüfe grundsätzlich bei jedemKínde meiner KlientelaufFazialis- und Radialisphiinomen ; dabeifand ich, daß im allgemeinen hei positivem Fauialisphänomcn auchdas Radialisphänomen auszulösen ist.In zahlreichen Fällen wurdeaber auch beiälteren Kindern (vom 3. Lebensjahr ab) der Stammdes N.radialis mechanisch übererregbar gefunden, hei negativemFazialisphänomen.Das Radialisphänomen beim älteren Kind gehtim allgemeinen parallel dein Peroneuspliäiionieii, seine Prüfung hatvor der des L u s t scheu Phänomens in der Sprechstunde den Vor-teil größerer Bequemlichkeit. Der Oberkörper des Kindes wird zurUntersuchung stetsentblößt, die Prüfung des Peroneusphänomenserfordert daneben Ablegen von Schuhen und Strümpfen. Das Gleichegiltfür Reihenuntersuchungen von Kindern hei Aussendung aufs Land und vor allem bei den Untersuchungen in den Schulen.Die Prüfung der Uebererregbarkeitphänomene solltehei den schuliirztlichcn Untersuchungen ganz besonders regelmäßig und sorg-fältig geschehen, sie sind als objektive Zeichen von größtem Wertfür die Beurteilung der Konstitution des Kindes." 0 7575 W2322804645.pdf 0 1 separator 0.90904444 ¶ 7575 7578 W2322804645.pdf 0 2 text 0.9997264 .Ein Vergleich zwischenFazialis-und Radialisphänomen beim älteren Kind ergibt ebenso wie beim Säugling clic größere Konstanzdes Radialisphänomens.Bei fortlaufender Beobachtung im Kinder-krankenhaus fanden wir häufig das Eazialisphänomen zu manchenTageszeiten-j-,zu anderen ; ebenso wechselte sein Auftretenan den einzelnen Tagen. Das Radíalispliänomen ist diesem Wechselkaum unterworfen.Hat man es einmal positiv gefunden, so bleibtes auch dauernd, wenn nicht durch therapeutische Eingriffe (Nar-kotika, Kalzium oder Brom) die Erregbarkeit vermindert wird.Die außerordentliche Häufigkeit der mechanischen Uebercrreg-barkeit beim älteren Kinde bei Fehlen allen sonstigen Erscheinungenvon Spasmophilie - die elektrische Ucbererregbarkeit fehlte min-destens bei einem grollen Teil unserer Krankenhausbeobachtungenverbietet es meiner Ansicht nach, diese Phänomene als Zeichen einerlatenten Spasmophilie zu deuten. Es würde das zu einer derartigen Verwässerung des Begriffes der Spasmophilie fuhren, daß von einemeingermaßen greifbaren Krankheitsbild keine Rede mehr sein könnte.DaßdasChvostekschewiedasRadialisphänomenauchbeim älteren Kinde jahreszeitliche Schwankungen zeigt, die etwa denen der Spasmophilie (kindliche Tetanie) entsprechen, braucht tins vondieser ablehnenden Auffassung nicht abzubringen; hat doch jüngsterst Moro darauf hingewiesen, daß auch andere krankhafte Zu-stände des Nervensystems, z. B. Psychosen, diesen klimatischen undmeteorologischen Einflüssen unterworfen sind.Mit zunehmender Uebung und Erfahrung lernt mari leicht dasRadialisphänomen je nach deni Ausfall der Reaktion einigermaßenquantitativ abzuschätzen, man bekommt damit einen immhin nichtganz unwichtigenBeitrag zur Konstitutiomisnote des betreffendenKindes.ist das Radmalisphänomen beim älteren Kind stark positiv,so wird man niemals sonstige Zeichen der neuropathisehen Kon-stitution vermissen. 7578 9458 W2322804645.pdf 0 3 paratext 0.9845562 I 44 DEUTSCHE MEDIZINISCHE WOCHENSC1-IRIFT Nr.41 9458 9506 W2322804645.pdf 0 4 separator 0.9225539 ¶ 9506 9508 W2322804645.pdf 0 5 paratext 0.96085525 Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages. 9508 9623 W2322804645.pdf 0 6 separator 0.99113667 ¶ 9623 9625 W2322804645.pdf 0 0 paratext 0.990179 J. Clin. Med. 2020 ,9, 1048 6 of 11 0 35 W3016007823.pdf 5 1 separator 0.9943739 ¶ 35 37 W3016007823.pdf 5 2 caption 0.9944553 "Figure 2. The respective numbers of renal transplants (red line) and the Google TrendsTMindices (blue line) are given for the United Nations of Organ Sharing (UNOS), the Organizaci ón Nacional de Trasplantes (ONT), the Eurotransplant areas, and the UK National Register. Numbers of deceased and living donor transplants are indicated by light and dark red areas. While there was a marginal increase in the Google TrendsTMindex observed in Spain, the curves obtained from the UNOS, Eurotransplant areas, and the UK National Register mirror the worldwide trend." 37 607 W3016007823.pdf 5 0 paratext 0.98151237 www.ccsenet.org/jas Journal of Agricu ltural Science V ol. 6, No. 12; 2014 0 74 W2147977287.pdf 6 1 separator 0.98320687 ¶ 75 77 W2147977287.pdf 6 2 bibliography 0.9980768 "113 Jabro, J. D., Sainju, L. I., Stevens, W. B., & Evans, R. G. (2008). Carbon dioxide flux as affected by tillage and irrigation in soil converted from perennial forages to annual crops. J. Environ. Manage., 88 , 1478-1484." 77 305 W2147977287.pdf 6 3 separator 0.5201036 ¶ 306 308 W2147977287.pdf 6 4 bibliography 0.9976123 http://dx.doi.org/10.1016/j.jenvman.2007.07.012 308 356 W2147977287.pdf 6 5 separator 0.9780999 ¶ 357 359 W2147977287.pdf 6 6 bibliography 0.9979758 "Kanwar, R. S. (1989). Effect of Tillage Systems on the Variability of Soil Water Tensions and Soil Water Content. Trans. ASAE, 32 , 605-610. http://dx.doi.org/10.13031/2013.31045" 359 541 W2147977287.pdf 6 7 separator 0.9711293 ¶ 542 544 W2147977287.pdf 6 8 bibliography 0.9981323 "Keshavarzpour, F., & Rashidi, M. (2008). Effect of diff erent tillage methods on soil physical properties and crop yield of watermelon ( Citrullus vulgaris ). World Appl. Sci. J., 3 , 359-364." 544 740 W2147977287.pdf 6 9 separator 0.9651966 ¶ 741 743 W2147977287.pdf 6 10 bibliography 0.99813765 "Khan, F. U. H., Tahir, A. R., & Yule, I. J. (2001). In trinsic implication of differ ent tillage practices on soil penetration resistance and crop growth. Int. J. Agri. Biol., 3 , 23-26." 743 933 W2147977287.pdf 6 11 separator 0.9602485 ¶ 934 936 W2147977287.pdf 6 12 bibliography 0.9981965 "Khurshid, K., Iqbal, M., Arif , M. S., & Nawaz, A. (2006). Effect of tillage and mulch on soil physical properties and growth of maize. Int. J. Agric. Biol., 8 , 593-596" 936 1109 W2147977287.pdf 6 13 separator 0.9702834 ¶ 1110 1112 W2147977287.pdf 6 14 bibliography 0.99820465 Kumar, S., Nakajima, T., Mbonimpa, E. G., Gautam, S ., Somireddy, U. R., Kadono, A., ... Fausey, N. (2014). 1112 1218 W2147977287.pdf 6 15 separator 0.75579417 ¶ 1219 1221 W2147977287.pdf 6 16 bibliography 0.9977654 "Long-term tillage and drainage influences on soil organic carbon dynamics, aggregate stability, and carbon yield. Soil Sci. Pl. Nut., 1 , 108-118. http://dx.doi.org/10.1080/00380768.2013.878643" 1221 1418 W2147977287.pdf 6 17 separator 0.968627 ¶ 1419 1421 W2147977287.pdf 6 18 bibliography 0.99822235 "Logsdon, S. D., Kaspar, T. C., & Cambardella, C. A. ( 1999). Depth incremental soil properties under no-tillage or chisel management. Soil Sci. Soc. Am. J., 63 , 197-200." 1421 1595 W2147977287.pdf 6 19 separator 0.73739135 ¶ 1596 1598 W2147977287.pdf 6 20 bibliography 0.9975101 http://dx.doi.org/ 10.2136/sssaj1999. 03615995006 300010028x 1598 1659 W2147977287.pdf 6 21 separator 0.9659952 ¶ 1660 1662 W2147977287.pdf 6 22 bibliography 0.998123 "Mahboubi, A. A., Lal, R., & Fausey, N. R. (1993). Twen ty-eight years of tillage effects on two soils in Ohio. Soil Sci. Soc. Am. J., 57 , 506-512. http://dx.do i.org/10.2136/sssaj199 3.03615995005 700020034x" 1662 1874 W2147977287.pdf 6 23 separator 0.9726727 ¶ 1875 1877 W2147977287.pdf 6 24 bibliography 0.9981325 "Ogban, P. I., Ekanem, T. P., & Etim, E. A. (2001). Effect of mulching methods on soil properties and growth and yield of maize in Southeastern Nigeria. Trop. Agric., 78 , 82-89." 1877 2058 W2147977287.pdf 6 25 separator 0.9621446 ¶ 2059 2061 W2147977287.pdf 6 26 bibliography 0.99804366 Ogban, P. I., Ogunewe, W. N., Dike, R. I., Ajaelo, A. C., Ikeata, N. I., Achumba, U. E., & Nyong, E. E. (2008). 2061 2173 W2147977287.pdf 6 27 separator 0.6351793 ¶ 2174 2176 W2147977287.pdf 6 28 bibliography 0.9977637 "Effect of tillage and mulching practices on so il properties and growth and yield of cowpea ( Vigna Unguiculata L.) in Southeastern Nigeria. J. Trop. Agri. Food, Envir. Exte., 7 , 118-128." 2176 2369 W2147977287.pdf 6 29 separator 0.96440494 ¶ 2370 2372 W2147977287.pdf 6 30 bibliography 0.9980046 "Ozpiner, S., & Cay, A. (2005). Eff ects of minimum and conventional tillage systems on soil properties and yield of winter wheat in clay-loa m in the Canakkale region. Turk. J. Agric. Forest., 29 , 9-18." 2372 2579 W2147977287.pdf 6 31 separator 0.970229 ¶ 2580 2582 W2147977287.pdf 6 32 bibliography 0.9977216 "Prasad, R. (2014). Using nitrogen and phosphorus budgets as effective tools for assessing nitrogen and phosphorus losses from agricultural systems (Ph.D. Diss.). Univ. of Florida, Gainesville." 2582 2780 W2147977287.pdf 6 33 separator 0.9607956 ¶ 2781 2783 W2147977287.pdf 6 34 bibliography 0.99813515 "Ram, H., Kaler, D. S., Singh, Y., & Kumar, K. (2010) Productivity of ma ize-wheat system under different tillage and crop establishment practices. Soil Till. Res., 113 , 48-54." 2783 2964 W2147977287.pdf 6 35 separator 0.964262 ¶ 2966 2968 W2147977287.pdf 6 36 bibliography 0.99443763 "Sarkar, S., & Singh, R. S. (2007). Interactive effect of tillage depth and mulch on soil temperature, productivity and water use pattern of rainfed barley ( Hordium vulgare L.). Soil Till. Res., 92 , 79-86. http://dx.doi.org/10.1016/j.still.2006.01.014" 2968 3228 W2147977287.pdf 6 37 separator 0.9727262 ¶ 3229 3231 W2147977287.pdf 6 38 bibliography 0.997796 "Sarkar, S., Paramanick, M., & Goswami, G. B. (2007). So il temperature, water use and yield of yellow sarson (Brassica napus L. var. glauca ) in relation to tillage intensity and mulch management under rainfed lowland ecosystem in eastern India. Soil Till. Res., 93 , 94-101. http://dx.doi.org/10.1016/j.still.2006.03.015" 3231 3560 W2147977287.pdf 6 39 separator 0.97706807 ¶ 3561 3563 W2147977287.pdf 6 40 bibliography 0.9981343 "Sen, A., Sharma, S. N., Singh, R. K., & Pandey, M. D. (2002). Effect of different tillage systems on the performance of wheat: Extn Bull (pp. 121-22). CCS Haryana Agricultural University, Hisar, India." 3563 3769 W2147977287.pdf 6 41 separator 0.9554379 ¶ 3770 3772 W2147977287.pdf 6 42 bibliography 0.99606085 "Shipitato, M. J., Dick, W. A., & Edwards, W. M. (2000). Conservation tillage and macrospore factors that affect water movement and the fate of chemicals. Soil Till. Res., 53 , 167-183. http://dx.doi.org/10.1016/S0167-1987(99)00104-X" 3772 4012 W2147977287.pdf 6 43 separator 0.9750679 ¶ 4013 4015 W2147977287.pdf 6 44 bibliography 0.99619186 "Sieling, K., Schroder, H., Finck, M., & Hanus, H. (1998). Yield, N uptake, and apparent N-use efficiency of winter wheat and winter barley gr own in different cropping systems. J. Agric. Sci., 131 , 375-87. http://dx.doi.org/10.1017/S0021859698005838" 4015 4272 W2147977287.pdf 6 45 separator 0.96910125 ¶ 4273 4275 W2147977287.pdf 6 46 bibliography 0.99802876 "Talaat, A. M. (2009). Assessment of infiltration rate parameters for water management in reclaimed area. Res. J. Agri. and Bio. Sci., 5 , 223-234." 4275 4427 W2147977287.pdf 6 47 separator 0.97392476 ¶ 4429 4431 W2147977287.pdf 6 48 bibliography 0.99641836 "Tessier, S., Peru, M., Dy ck, F. B., Zentner, R. P., & Campbell, C. A. (1990). Conservation tillage for spring wheat production in semi-arid Saskatchewan. Soil Till. Res., 18 , 73-89. http://dx.doi.org/10.1016/0167-1987(90)90094-T" 4431 4668 W2147977287.pdf 6 49 separator 0.9817684 ¶ 4669 4671 W2147977287.pdf 6 50 bibliography 0.9978582 Tripathi, S. C., & Chauhan, D. S. (2000). Evaluation of fertilizer and seed rate in wheat under different tillage 4671 4785 W2147977287.pdf 6 0 text 0.99843186 "diabetes is far less expensive and has lower unit costs than treatment interventions for those conditions. Further, outpatient treatment is far less costly than inpatient treatment, so it is critical to have an effective referral system that directs patients to the proper facility [25]." 0 295 W1984856979.pdf 4 1 separator 0.9811451 ¶ 295 297 W1984856979.pdf 4 2 text 0.99952614 "Using China, an upper-middle income country, as an example, population-level primary prevention of diabetes- through media campaigns- costs well under one USD per capita per year. However, treatment of uncomplicated dia- betes costs nearly 1000USD and treatment of complicated diabetes costs nearly 2,500USD [26,27]." 297 624 W1984856979.pdf 4 3 separator 0.95654446 ¶ 624 626 W1984856979.pdf 4 4 text 0.9992852 "A costed NCD strategy is a starting place for deter- mining the scope and pace of scaling up NCD services in Uganda. There are many existing tools and sources of costing information [28]. Although it will take time for Uganda to develop a full array of costs for providing NCD services, the success of an NCD strategy will ultimately depend upon a local understanding of costs and benefits." 626 1029 W1984856979.pdf 4 5 separator 0.9973124 ¶ 1029 1031 W1984856979.pdf 4 6 title 0.99298716 Ministry of health financing for NCDs 1031 1069 W1984856979.pdf 4 7 separator 0.99570227 ¶ 1069 1071 W1984856979.pdf 4 8 text 0.9992209 "In 2006, The Ugandan Ministry of Health (MoH) estab- lished the Programme for the Prevention and Control of NCDs. This small unit is one of nine divisions within the Department of Community Health and is responsible for all national NCD-related activities. A separate division, Health Promotion, is actually responsible for promoting healthy lifestyle changes in the population. According to the Government of Uganda Ministry of Health Ministerial Policy Statement 2014/2015, the NCD Programme is allo- cated 0.01 percent of the total MoH budget, representing three percent of the Departmental budget, or approxi- mately 27,000USD per annum. The Programme budget iscurrently supplemented by a five-year grant from the World Diabetes Federation (WDF) that expires at the end of 2017 and that brings the total budget to approximately 270,000USD. For the current fiscal year, NCD Programme funding was increased to 25% of the total Departmental budget to allow for the completion of STEPS (Table 2) [un- published data, Government of Uganda Ministry of Health]." 1071 2164 W1984856979.pdf 4 9 separator 0.9963038 ¶ 2164 2166 W1984856979.pdf 4 10 title 0.9924414 Current efforts to combat NCDs in Uganda 2166 2207 W1984856979.pdf 4 11 separator 0.97404754 ¶ 2207 2209 W1984856979.pdf 4 12 title 0.9821003 Public sector NCD capacity 2209 2236 W1984856979.pdf 4 13 separator 0.9884275 ¶ 2236 2238 W1984856979.pdf 4 14 text 0.9990885 "An NCD needs assessment conducted in 2013 character- ized, for the first time in Uganda, the capacity of regional and general hospitals and high-level (Level IV) health centers to provide NCD-related services. It evaluated human resources, equipment, drug supply, and laboratory" 2238 2525 W1984856979.pdf 4 15 separator 0.9790406 ¶ 2525 2527 W1984856979.pdf 4 16 caption 0.9957064 Figure 3 Trends in age-standardized incidence rates of selected cancers in males and females in Kampala, Uganda, 1991 –2006. 2527 2652 W1984856979.pdf 4 17 separator 0.6077518 2652 2653 W1984856979.pdf 4 18 caption 0.94879794 ¶ (Adapted from Parkin [14]). 2653 2682 W1984856979.pdf 4 19 separator 0.9746908 ¶ 2682 2684 W1984856979.pdf 4 20 table 0.9304612 "Table 2 Ministry of health financing for NCDs [provided by personal communication: Ministry of Health Ministerial Policy Statement 2014/2015, the Republic of Uganda] Approximate budget (USD), 2014-15Percent of total MOH budget Ministry of Health 240,000,000 - Source: Government of Uganda20,000,000 8.3 Source: External financing 220,000,000 91.7 Department of Community Health902,000 0.37 Programme for the Prevention and Control of NCDs27,000*0.011 *The NCD Programme budget was increased from 3% (27,000USD) of Department of Community Health budget to 25% (250,000USD) for 2014 –15 " 2684 3302 W1984856979.pdf 4 21 separator 0.5782686 ¶ 3302 3303 W1984856979.pdf 4 22 table 0.79316956 to fund the STEPS survey 3303 3328 W1984856979.pdf 4 23 paratext 0.9390547 ".Schwartz et al. Globalization and Health 2014, 10:77 Page 5 of 9 http://www.globalizationandhealth.com/content/10/1/77" 3328 3449 W1984856979.pdf 4 0 paratext 0.96644646 "¶ 2021 | International Journal of Education, Science, Technology and Engineering | Volume. 4 | Issue. 2 | 105-111 ¶ International Journal of Education, Science, Technology and Engineering p-ISSN: 2685-1458, e-ISSN: 2684-9844" 1 236 W4200274990.pdf 0 1 separator 0.94049144 ¶ 239 241 W4200274990.pdf 0 2 title 0.9394107 Original Research Paper 241 265 W4200274990.pdf 0 3 separator 0.65932786 ¶ ¶ 266 272 W4200274990.pdf 0 4 title 0.9310965 Development and Application of Nanoparticle Technology in Herbal Drug Formulation: A 272 359 W4200274990.pdf 0 5 separator 0.46504226 ¶ 359 360 W4200274990.pdf 0 6 title 0.89776987 Review 360 367 W4200274990.pdf 0 7 separator 0.97335744 ¶ ¶ 368 374 W4200274990.pdf 0 8 contact 0.9746355 "Roosma Hatmayana1, Syafira Nabillah1, Yuditha Mutia Windy1, Noval1 ¶ 1 Department of Pharmacy, Faculty of Health, Sari Mulia University. Banjarmasin, Indonesia." 374 540 W4200274990.pdf 0 9 separator 0.4472983 ¶ 541 548 W4200274990.pdf 0 10 paratext 0.4131228 "¶ ¶ ¶ " 548 568 W4200274990.pdf 0 11 math 0.40103462 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 568 669 W4200274990.pdf 0 12 separator 0.3546881 671 672 W4200274990.pdf 0 13 math 0.33585516 ¶ 672 673 W4200274990.pdf 0 14 separator 0.74213994 "¶ ¶ ¶" 675 689 W4200274990.pdf 0 15 title 0.8479075 Article History 690 706 W4200274990.pdf 0 16 separator 0.96833766 ¶ 707 709 W4200274990.pdf 0 17 paratext 0.49042842 "Received: 18.11.2021 ¶ Revised:" 709 749 W4200274990.pdf 0 18 table 0.40371174 ¶ 750 752 W4200274990.pdf 0 19 paratext 0.49184504 21.12.2021 752 763 W4200274990.pdf 0 20 table 0.3543362 ¶ 764 766 W4200274990.pdf 0 21 paratext 0.48524347 ¶ Accepted: 768 782 W4200274990.pdf 0 22 table 0.3268153 ¶ 782 783 W4200274990.pdf 0 23 paratext 0.612706 27.12.2021 783 794 W4200274990.pdf 0 24 separator 0.5869977 ¶ ¶ 795 801 W4200274990.pdf 0 25 contact 0.99623203 "*Corresponding Author: Roosma Hatmayana Email: roosmayn@gmail.com" 801 878 W4200274990.pdf 0 26 paratext 0.41553366 879 880 W4200274990.pdf 0 27 contact 0.48639074 ¶ 880 881 W4200274990.pdf 0 28 paratext 0.9240507 "¶ This is an open access article, licensed under: CC–BY-SA" 883 945 W4200274990.pdf 0 29 separator 0.896248 ¶ ¶ 947 953 W4200274990.pdf 0 30 text 0.9975487 "Abstract: Formulations of Herbal medicine are continuously being developed to improve health and treatment through natural ingredients obtained from the surrounding environment with scientific evidence. Common problems in herbal medicine are bioavailability, solubility, absorption of active substances and low stability. Recently, it has become a development trend to enter the realm of nanoparticle technology to its application in herbal drug formulations. Nanoparticle technology is a technology of drug particles are made on the nanoscale (10 nm-1000 nm). Many studies have been carried out on the development and application of nanoparticle-based delivery technology containing natural ingredients, from these results nanoparticle- based delivery technology has succeeded in delivering these natural materials through certain mechanisms in increasing the activity and bioavailability of herbal medicinal compounds. Particles at the nanoparticle scale have distinctive physical properties compared to particles at a larger size, especially in increasing the amount and purpose of delivering drug compounds. Another advantage of nanoparticle technology is the potential to be combined with other technologies, thus opening up opportunities to produce more perfect and targeted delivery systems. Examples of nanotechnologies that can be used are polymer nanoparticles, solid lipid particles, magnetic nanoparticles, and others. The manufacture of preparations based on nanoparticle technology is an alternative in the manufacture of herbal medicines and it is hoped that the bioavailability and therapy produced in the body will be better. ¶" 954 2665 W4200274990.pdf 0 31 separator 0.676514 ¶ 2667 2669 W4200274990.pdf 0 32 text 0.6788077 Keywords: Herbal Drug, Nanoparticle, Nano Technology 2669 2722 W4200274990.pdf 0 33 paratext 0.45083725 . 2722 2723 W4200274990.pdf 0 0 paratext 0.98906714 Appl. Sci. 2022 ,12, 2018 7 of 8 0 32 W4213269958.pdf 6 1 separator 0.9896018 ¶ 32 34 W4213269958.pdf 6 2 title 0.988952 4. Conclusions 34 49 W4213269958.pdf 6 3 separator 0.9959507 ¶ 49 51 W4213269958.pdf 6 4 text 0.99939024 "In this paper, an analytical method for calculating the insertion loss of barriers on the ground was described. In line with the theory, the time-domain method for wedge diffraction proposed by Svensson et al. was combined with the classic image method for the analysis of sound propagation over a barrier on the ground. The accuracy of the proposed method was validated using the classic MacDonald method. Moreover, the proposed method has faster processing speed than the conventional MacDonald method." 51 566 W4213269958.pdf 6 5 separator 0.7154191 ¶ 566 568 W4213269958.pdf 6 6 text 0.99906063 "In addition, the proposed method can calculate the whole frequency range at the same time due to the nature of the time domain, while frequency-domain methods have to repeat the process point by point in the range of interest. However, the proposed method is currently restricted more by the fact that it does not allow for absorbent barriers and impedance ground. Thus, our future work will focus on an extension of our method to absorbent barriers and finite impedance ground. Moreover, predictions of a finite barrier or moving source effects would be interesting." 568 1146 W4213269958.pdf 6 7 separator 0.996168 ¶ 1146 1148 W4213269958.pdf 6 8 bibliography 0.969481 "Author Contributions: Conceptualization, J.G.; methodology, J.G.; software, J.G. and X.F.; validation, J.G.; formal analysis, J.G.; investigation, J.G.; resources, J.G. and Y.S.; data curation, J.G.; writing— original draft preparation, J.G.; writing—review and editing, J.G., X.F. and Y.S.; visualization, J.G.; supervision, X.F. and Y.S.; project administration, X.F. and Y.S. All authors have read and agreed to the published version of the manuscript." 1148 1612 W4213269958.pdf 6 9 separator 0.9886792 ¶ 1612 1614 W4213269958.pdf 6 10 paratext 0.74969333 Funding: This research received no external funding. 1614 1667 W4213269958.pdf 6 11 separator 0.96847695 ¶ 1667 1669 W4213269958.pdf 6 12 paratext 0.6049101 Institutional Review Board Statement: Not applicable. 1669 1723 W4213269958.pdf 6 13 separator 0.8807214 ¶ 1723 1725 W4213269958.pdf 6 14 paratext 0.53450567 Informed Consent Statement: Not applicable. 1725 1769 W4213269958.pdf 6 15 separator 0.7861045 ¶ 1769 1771 W4213269958.pdf 6 16 paratext 0.4495199 Data Availability Statement 1771 1799 W4213269958.pdf 6 17 bibliography 0.37757307 : 1799 1800 W4213269958.pdf 6 18 paratext 0.42578518 Not applicable. 1800 1816 W4213269958.pdf 6 19 separator 0.8987094 ¶ 1816 1818 W4213269958.pdf 6 20 paratext 0.59785867 Conflicts of Interest: The authors declare no conflict of interest. 1818 1884 W4213269958.pdf 6 21 separator 0.993958 ¶ 1884 1886 W4213269958.pdf 6 22 title 0.7522218 References 1886 1897 W4213269958.pdf 6 23 separator 0.98999333 ¶ 1897 1899 W4213269958.pdf 6 24 bibliography 0.9979386 "1. 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The Alchemy of Probability Distributions: Beyond Gram- Charlier Expansions, and a Skew-kurtotic Normal Distribution from a Rank Transmutation Map." 2414 2600 W1945950696.pdf 11 36 separator 0.97426534 ¶ 2600 2602 W1945950696.pdf 11 37 bibliography 0.968263 arXiv preprint, arXiv:0901.0434, 2009. 2602 2641 W1945950696.pdf 11 0 title 0.9850822 Supplementary Table S2: Details of riboprobes used in RNase protection assays 0 79 W2122184087.pdf 1 1 separator 0.98736024 "¶ ¶" 80 90 W2122184087.pdf 1 2 table 0.99481463 "abbreviation gene species accession number 5’ end 3’ end protected length(bp) μg of total RNA hybridised HIF-1α hypoxia inducible factor 1α human U22431 759 1017 240 40 HIF-2α hypoxia inducible factor 2α human U81984 2542 2762 210 40 VEGF Vascular endothelial growth factor human M63971 2280 2502 140 40 Glut-1 glucose transporter 1 human K03195 1063 1198 136 30 CA-9 carbonic anhydrase 9 human Z54349 3631 3777 146 40 U6sn U6 small nuclear RNA human X01366 1 107 106 1 (1/10 loaded on gel)" 90 655 W2122184087.pdf 1 3 separator 0.9648939 ¶ ¶ 656 662 W2122184087.pdf 1 0 paratext 0.990616 Information 2020 ,11, 352 7 of 30 0 33 W3038482006.pdf 6 1 separator 0.99536306 ¶ 33 35 W3038482006.pdf 6 2 text 0.99965954 "Such relocations brought about by lateral gene transfer contribute to a reduction of the endosymbiont genome and it facilitates an overall orchestration of functional unity to the benefit of the cell and the entire organism. Explaining such alterations simply cannot be reduced to a genetic (nuclear or organellar) level. On the contrary, any such genetic exchange between organelles and nuclei brings to light the existence of higher-level entities such as the cell whose variation is altered because of the repeated genetic exchanges." 35 581 W3038482006.pdf 6 3 separator 0.99696887 ¶ 581 583 W3038482006.pdf 6 4 title 0.99293 3.1.3. Infective Heredity 583 609 W3038482006.pdf 6 5 separator 0.9966733 ¶ 609 611 W3038482006.pdf 6 6 text 0.9997849 "Upon infection, bacteriophages can take on a lysogenic (avirulent) phase that precedes the lytic (virulent) phase [ 68]. During the lytic phase, the phage uses the host metabolism to make more viral particles and it ends up destroying the host upon release. However, in their lysogenic phase, bacteriophages integrate into the host genome (a process known as lysogenization) at which point they are called prophages. As prophages, they act as symbionts, and the nature of the symbiosis can often be characterized as mutualistic." 611 1150 W3038482006.pdf 6 7 separator 0.9601238 ¶ 1150 1152 W3038482006.pdf 6 8 text 0.99977326 "An example is the lambda phage that infects E. coli bacteria [ 97]. During its lysogenic phase, the phage’s DNA integrates into the bacterial genome of its E. coli host. In this condition, the phage finds shelter and protection from unfavorable environmental conditions, and the phage increases the genetic variation found in the host. It also increases metabolic and phenotypic variation of the E. coli bacterium, because some of the phage’s genes are active, resulting in the bacterium demonstrating phenotypic properties it cannot produce by itself. An example is resistance to serum killing (animal blood contains antibacterial antibodies), which is a trait induced by genes coming from the lambda prophage, portrayed by the E. coli bacterium, which enables it to survive inside the bloodstream of numerous animals [98,99]." 1152 1995 W3038482006.pdf 6 9 separator 0.979167 ¶ 1995 1997 W3038482006.pdf 6 10 text 0.9996844 "Phage infection also contributes to the overall genetic variation of E. coli on a higher species level because, during division, the bacterial host passes on the integrated prophage genes to the next generation. This is also beneficial for lambda that, without any costs involved, is able to spread and increase in number each time lysogenic E. coli undergo division." 1997 2370 W3038482006.pdf 6 11 separator 0.9770819 ¶ 2370 2372 W3038482006.pdf 6 12 text 0.99975026 "A special case of variation is attributed to mobile genetic elements [ 14] such as transposons, retrotransposons and retroviruses. Transposons and retrotransposons are found in both pro- and eukaryotes, and, in the latter, they have been implicated in numerous cancers as well as autoimmunity and neurodegenerative diseases [ 100]. Transposons or “jumping genes” [ 101,102] are mobile genetic elements that mostly cut themselves from their original site on the genome to subsequently integrate at a di erent location. Retrotransposons move about by a copy and paste mechanism [ 103], and thus duplicate." 2372 2989 W3038482006.pdf 6 13 separator 0.96374226 ¶ 2989 2991 W3038482006.pdf 6 14 text 0.99975294 "When transposons integrate at a di erent location, they often alter or interrupt active genes and the metabolic pathways that these genes encode for. Rather than consider them as junk DNA, the inserted sequences are often sources of evolutionary innovation because they underlie novel metabolic features and phenotypic alterations (for a discussion, see [ 104]). Both transposons and retrotransposons thus alter existing variation, and they have the potential to introduce novel genetic interactions that in turn have the potential to introduce novel traits with phenotypic e ects." 2991 3585 W3038482006.pdf 6 15 separator 0.9809455 ¶ 3585 3587 W3038482006.pdf 6 16 text 0.99970126 "Other mobile genetic elements are endogenous retroviruses that have permanently integrated into the eukaryotic genome. As “gene delivery vectors” [ 105], they form an integrated part of the genome where they are passed on to future generations via sexual recombination, thereby contributing to the overall genetic variation of the species." 3587 3933 W3038482006.pdf 6 17 separator 0.996943 ¶ 3933 3935 W3038482006.pdf 6 18 title 0.99218875 3.1.4. Hybridization 3935 3956 W3038482006.pdf 6 19 separator 0.997055 ¶ 3956 3958 W3038482006.pdf 6 20 text 0.9914721 "Hybridization increases variation at a genetic, phenotypic, sub-species, and species level [ 86]. Most certainly common in plants, an extensive review written by Arnold, Brothers, and Hamlin [ 106] also demonstrates the occurrence of hybridization in the following mammals: marsupials, rabbits and hares, mice, rats, chipmunks, minks and polecats, polar and brown bears, Florida panthers," 3958 4353 W3038482006.pdf 6 0 paratext 0.96030885 "12 Vol:.(1234567890) Scientific Reports | (2022) 12:18510 | https://doi.org/10.1038/s41598-022-22631-0" 0 113 W4309508320.pdf 11 1 separator 0.64459586 ¶ 113 115 W4309508320.pdf 11 2 paratext 0.59527886 www.nature.com/scientificreports/Correspondence and requests for materials should be addressed to M.A.B. 115 220 W4309508320.pdf 11 3 separator 0.8847234 ¶ 220 222 W4309508320.pdf 11 4 text 0.38514367 Re 222 225 W4309508320.pdf 11 5 paratext 0.43301705 prints 225 231 W4309508320.pdf 11 6 text 0.44014934 and permissions information 231 259 W4309508320.pdf 11 7 paratext 0.41579354 is 259 262 W4309508320.pdf 11 8 text 0.4103093 available 262 272 W4309508320.pdf 11 9 paratext 0.42272618 at 272 275 W4309508320.pdf 11 10 text 0.38915122 www.nature.com 275 290 W4309508320.pdf 11 11 paratext 0.45354518 /reprints. 290 300 W4309508320.pdf 11 12 separator 0.98234224 ¶ 300 302 W4309508320.pdf 11 13 text 0.5082057 Publisher 302 312 W4309508320.pdf 11 14 title 0.51600075 ’s 312 314 W4309508320.pdf 11 15 text 0.7110849 "note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 314 441 W4309508320.pdf 11 16 separator 0.9820608 ¶ 441 443 W4309508320.pdf 11 17 paratext 0.87469876 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/." 443 1327 W4309508320.pdf 11 18 separator 0.77742904 ¶ 1327 1329 W4309508320.pdf 11 19 paratext 0.9505548 © The Author(s) 2022 1329 1350 W4309508320.pdf 11 0 paratext 0.83353406 "Review of: ""The Aesthetic of the Nakikibakang Loob: Kiri Dalena’s Militant and Transcendent Art""" 0 98 W4392785623.pdf 0 1 separator 0.70656157 ¶ 98 100 W4392785623.pdf 0 2 paratext 0.583334 "Marivi Veliz 1 1" 100 121 W4392785623.pdf 0 3 contact 0.44147986 ¶ 121 123 W4392785623.pdf 0 4 paratext 0.40661532 W 124 126 W4392785623.pdf 0 5 contact 0.4310719 ichita State University 126 149 W4392785623.pdf 0 6 separator 0.96027976 ¶ 149 151 W4392785623.pdf 0 7 title 0.58612037 Potential competing interests 151 181 W4392785623.pdf 0 8 text 0.7721691 : 181 182 W4392785623.pdf 0 9 separator 0.82760036 ¶ 182 184 W4392785623.pdf 0 10 text 0.98304474 No potential competing interests to declare. 185 230 W4392785623.pdf 0 11 separator 0.8434405 ¶ 230 232 W4392785623.pdf 0 12 text 0.966581 The essay is well written and tied up. I truly enjoyed the reading. However, I have some comments: 232 331 W4392785623.pdf 0 13 separator 0.9595542 ¶ 331 333 W4392785623.pdf 0 14 text 0.6099669 "1 ." 333 339 W4392785623.pdf 0 15 separator 0.42950246 ¶ 340 342 W4392785623.pdf 0 16 text 0.8870248 "The translation of kapwa and loob should be provided in the abstract." 342 424 W4392785623.pdf 0 17 separator 0.9724746 ¶ 425 427 W4392785623.pdf 0 18 table 0.45046 2 ¶ 427 431 W4392785623.pdf 0 19 text 0.47516322 . 431 433 W4392785623.pdf 0 20 separator 0.93526274 ¶ 434 436 W4392785623.pdf 0 21 text 0.8229437 First section heading should be “Social Realism and Bring 436 494 W4392785623.pdf 0 22 title 0.5199583 ing 494 497 W4392785623.pdf 0 23 text 0.84410524 "to Light the Darkest Depths of the Loob” The h in Depths is missing." 497 574 W4392785623.pdf 0 24 separator 0.97851217 ¶ 575 577 W4392785623.pdf 0 25 table 0.415561 3 ¶ 577 581 W4392785623.pdf 0 26 text 0.39186388 . 581 583 W4392785623.pdf 0 27 separator 0.95619494 ¶ 584 586 W4392785623.pdf 0 28 text 0.99553823 "In the first paragraph, there is a typo. “Levias” instead of Levinas. In this sentence, I think that some adjectives would help to contextualize the theoretical framework or the theorists. For example, French or poststructuralist philosopher Emmanuel Levinas, Filipino poet Albert Alejo, etc." 586 883 W4392785623.pdf 0 29 separator 0.9685877 ¶ 884 886 W4392785623.pdf 0 30 table 0.3469468 "4 " 886 891 W4392785623.pdf 0 31 text 0.34447408 . 891 892 W4392785623.pdf 0 32 separator 0.97950315 ¶ 893 895 W4392785623.pdf 0 33 text 0.3604995 Paragraph 4. The 895 912 W4392785623.pdf 0 34 caption 0.41774714 word 912 917 W4392785623.pdf 0 35 text 0.34714898 ¶ ladrones 918 930 W4392785623.pdf 0 36 separator 0.2618503 ¶ 930 931 W4392785623.pdf 0 37 text 0.35453767 should 932 939 W4392785623.pdf 0 38 caption 0.37623423 be replace 939 950 W4392785623.pdf 0 39 text 0.40184048 d 950 951 W4392785623.pdf 0 40 caption 0.46398738 with 951 956 W4392785623.pdf 0 41 text 0.31997812 957 958 W4392785623.pdf 0 42 separator 0.28732395 ¶ 958 959 W4392785623.pdf 0 43 text 0.38820574 ladrón 959 966 W4392785623.pdf 0 44 separator 0.9726893 ¶ 966 968 W4392785623.pdf 0 45 text 0.4074045 "5 ." 968 974 W4392785623.pdf 0 46 separator 0.9310087 ¶ 975 977 W4392785623.pdf 0 47 text 0.9987442 "Since social realism in Art History refers to a specific period and a style loaded by propaganda and didactic purposes, the use of the term should be explained further. What’s the artist's background? What has been said about her work, and what makes the author identify Dalena’s work with social realism?" 977 1287 W4392785623.pdf 0 48 separator 0.6467113 ¶ 1287 1289 W4392785623.pdf 0 49 text 0.73140305 "6 ." 1289 1295 W4392785623.pdf 0 50 separator 0.94983006 ¶ 1296 1298 W4392785623.pdf 0 51 text 0.9993352 "The ambivalence and fascinating contradiction between erasing the human (with no traces, according to the author) and the Other’s traces in Levinas terms could be explored. The author seems to argue that there is a level of connection that never disappears. Is it the power of the Loob? If so, it is full of traces." 1298 1618 W4392785623.pdf 0 52 separator 0.91041285 ¶ ¶ 1619 1625 W4392785623.pdf 0 53 paratext 0.9570196 "Qeios, CC-BY 4.0 · Review, February 2, 2024 Qeios ID: T2GV0A · https://doi.org/10.32388/T2GV0A 1 /" 1625 1741 W4392785623.pdf 0 54 separator 0.6957151 ¶ 1 1741 1745 W4392785623.pdf 0 0 paratext 0.97259957 31doi: 10 .5937/SelSem2002031SSELEKCIJA I SEMENARSTVO, Vol . XXVI (2020) broj 2 0 80 W3123780265.pdf 0 1 separator 0.9570184 ¶ 80 82 W3123780265.pdf 0 2 title 0.9862963 "IDENTIFIKACIJA POTOMSTAV A BEZ KUNITZ TRIPSIN INHIBITORA KOD UKRŠTANJA SOJE U PUNOM SRODSTVU" 82 179 W3123780265.pdf 0 3 separator 0.9890349 ¶ 179 181 W3123780265.pdf 0 4 contact 0.55956554 Mir 181 185 W3123780265.pdf 0 5 text 0.6527628 jana Srebrić 185 197 W3123780265.pdf 0 6 contact 0.5911637 1* 197 199 W3123780265.pdf 0 7 text 0.5334052 , Dragan K 199 209 W3123780265.pdf 0 8 contact 0.47085565 ovač 209 213 W3123780265.pdf 0 9 text 0.49803218 ević 213 217 W3123780265.pdf 0 10 contact 0.6506568 1, Vesna Perić1 217 232 W3123780265.pdf 0 11 separator 0.98147637 ¶ 232 234 W3123780265.pdf 0 12 text 0.5299926 Izvod 234 240 W3123780265.pdf 0 13 separator 0.9349487 ¶ 240 242 W3123780265.pdf 0 14 text 0.99952894 "Kunitz tripsin inhibitor (KTI) je deo antihranljivog kompleksa prisutnog u zrnu soje . Zrno soje bez KTI može da se koristi u ishrani nepreživara bez prethodne termičke obrade . U cilju dobijanja linija soje sa smanjenim sadržajem anti-hranljivih materija u zrnu, na prvom mestu bez KTI, izvršeno je ukrštanje adaptiranog genotipa standardnog kvaliteta zrna (sorta Kador) sa genotipom bez KTI slabije adaptiranim na naše uslove gajenja (sorta Kunitz) . Dobijena je segregirajuća generacija iz koje su za novi ciklus ukrštanja odabrane tri najprinosnije F3 linije, hetereozigotne za prisustvo KTI . Realizovane su dve kombinacije ukrštanja u punom srodstvu (full-sib - FS) sa različitim brojem uspešno ukrštenih biljaka . Utvrđivanje prisustva KTI u po- tomstvima razvijenim iz odabranih linija poreklom iz ukrštanja Kunitz x Kador i njihovih kom- binacija FS ukrštanja, izvršeno je pomoću proteinskih markera na nativnom poliakrilamidnom gelu . Na osnovu elektroforegrama je uočeno da trake koje odgovaraju poziciji KTI nisu istog intenziteta . Analiza je rađena iz grupnog uzorka, tako da je moguće da se u uzorku nalaze zrna sa i bez KTI . Na elektroforegramu je identifikovano deset potomstava linija majki i pet potomstava FS ukrštanja bez trake koja odgovara poziciji KTI . Ukupno četiri potomstva sa prinosom zrna po biljci na nivou i boljim od prinosnijeg roditelja mogu se smatrati perspektivnim za dalji postupak odabiranja ." 242 1724 W3123780265.pdf 0 15 separator 0.9097269 ¶ 1724 1726 W3123780265.pdf 0 16 text 0.9948039 Ključne reči : soja, ukrštanje u punom srodstvu, Kunitz tripsin inhibitor, proteinski markeri 1726 1820 W3123780265.pdf 0 17 separator 0.9921 ¶ 1820 1822 W3123780265.pdf 0 18 title 0.93574303 Originalni naučni rad (Original Scientific Paper) 1822 1872 W3123780265.pdf 0 19 separator 0.99401206 ¶ 1872 1874 W3123780265.pdf 0 20 contact 0.99535877 "1 Srebrić M, Kovačević D, Perić V , Institut za kukuruz „Zemun Polje“, Slobodana Bajića 1 ., Beograd-Zemun, Srbija * e-mail: msrebric@mrizp .rs" 1874 2021 W3123780265.pdf 0 21 title 0.90746903 Uvod 2022 2027 W3123780265.pdf 0 22 separator 0.99368227 ¶ 2027 2029 W3123780265.pdf 0 23 text 0.99954176 "Soja predstavlja jednu od najvažnijih gaje- nih biljnih vrsta zbog sadržaja pre svega kvali- tetnih proteina i ulja . Iako se najveće količine proizvedenog zrna soje u svetu koriste za ishra- nu domaćih životinja (sačme, pogače, griz), zrno soje se sve više koristi i za ljudsku ishranu (brašno, teksturirani belančevinasti koncen- trati sa 38-95% proteina) . U prehrambenoj, hemijskoj i farmaceutskoj industriji, zrno soje je značajna sirovina (Vratarić i Sudarić, 2008) ." 2029 2526 W3123780265.pdf 0 24 separator 0.7215245 ¶ 2526 2528 W3123780265.pdf 0 25 text 0.99956864 "Osim korisnih sastojaka, zrno soje sadrži i kompleks antihraljivih supstaci (Mikić et al ., 2009) od kojih su najviše proučavane: tripsin inhibitori, hemaglutinin, saponin, goitrogeni faktori, alergeni, flatulenske supstance, lipok- sidaza, ureaza . Smatra se da su glavni antinu- tritvni faktori tripsin inhibitori i lektin (Bec- ker-Ritt et al ., 2004; Gu et al ., 2010) . Tripsin inhibitori (Kunitz i Bowman-Birk tripsin in- hibitor) spadaju u proteine i učestvuju sa oko 6% od ukupnih proteina u zrelom zrnu soje ." 2528 3074 W3123780265.pdf 0 26 separator 0.6807013 ¶ 3075 3077 W3123780265.pdf 0 27 text 0.9981644 "Kunitz tripsin inhibitor (KTI) se smatra sup- stancom sa najjačim inhibirajućim delovanjem u zrelom zrnu soje (Watanabe et al ., 2018) ." 3077 3221 W3123780265.pdf 0 28 separator 0.9159418 ¶ 3221 3223 W3123780265.pdf 0 29 text 0.9988508 "U sistemu za varenje monogastričnih živo- tinja i čoveka tripsin inhibitori blokiraju pro- teolitičke fermente i na taj način ometaju nor - malnu razgradnju molekula korisnih proteina (Kim et al ., 2010) . Blokiranje funkcije proteo- litičkih fermenata pouzrokuje hiperfunkciju a" 3223 3515 W3123780265.pdf 0 0 paratext 0.9795004 "IJAE Vol. 125, n. 1: 11- 17, 2021 © 2021 Firenze University Press http://www.fupress.com/ijaeITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY DOI: 10.36253/ijae-11871*" 0 172 W4229372335.pdf 0 1 contact 0.98669446 Corresponding author. E-mail: guarna@unisi.it 172 218 W4229372335.pdf 0 2 title 0.9884157 "Elongated styloid process: literature review and morphometric data on a collection of dried skulls" 218 319 W4229372335.pdf 0 3 separator 0.9887176 ¶ 319 321 W4229372335.pdf 0 4 contact 0.9936139 "Massimo Guarna*, Paola Lorenzoni, Nila Volpi, Margherita Aglianò Dipartimento di Scienze mediche, chirurgiche e Neuroscienze, Università degli studi di Siena, Siena, Italy" 321 495 W4229372335.pdf 0 5 separator 0.9930834 ¶ 495 497 W4229372335.pdf 0 6 title 0.91937625 Abstract 497 506 W4229372335.pdf 0 7 separator 0.99480057 ¶ 506 508 W4229372335.pdf 0 8 text 0.9996203 "The styloid process is a subtle process of variable length that originates from the petrous part of temporal bone . From the process originate three muscles: the stylopharyngeus,the styloglos- sus, the stylohyoideus and two ligaments :stylohyoid and stylomandibular . The styled process of the temporal bone has a variable length as demonstrated for studies conducted in three- dimensional computed tomography or dental panoramic three-dimensional scanning,and in dried skulls The normal length of the styloid process is particularly important to establish for the relations of closeness with vascular and nervous structures and their possible compression by an elongated styloid process.Several studies have focused on the effects of changes in length and course of the styloid process, highlighting the relations of the carotid artery and the glos- sopharyngeal nerve to explain cerebrovascular symptoms or Eagle’s syndrome characterized by neck pain and dysphagia .However the association for the abnormal length of styloid process and Eagle’s syndrome is not always present and many cases are asymptomatic. In the present study we propose a review of the studies performed with different in vivo radiological tech- niques and on dried skull collections on the normal and pathological length of the stiloyd pro- cess and on its association with the Eagle’s syndrome. We also present a morphometric study carried out in dried skulls of our museum collection.The results are discussed in light of the possible variations in the muscular and ligamentous structures consequent to the elongation of the styloid process." 508 2172 W4229372335.pdf 0 9 separator 0.9970194 ¶ 2172 2174 W4229372335.pdf 0 10 title 0.8898573 Keywords 2174 2183 W4229372335.pdf 0 11 separator 0.9927882 ¶ 2183 2185 W4229372335.pdf 0 12 text 0.96310556 Elongated styloid process, Eagle’s syndrome. 2185 2230 W4229372335.pdf 0 13 separator 0.9955193 ¶ 2230 2232 W4229372335.pdf 0 14 title 0.93859464 Introduction 2232 2245 W4229372335.pdf 0 15 separator 0.994796 ¶ 2246 2248 W4229372335.pdf 0 16 text 0.9964099 "The styloid process (SP) is a subtle pointed process of variable length that origi- nates from the petrous portion of temporal bone and is localized anteriorly to the sty- lomastoid foramen. From the process originate three muscles: the stylopharyngeus,the styloglos- sus, the stylohyoideus and two ligaments :stylohyoid and stylomandibular . The SP projects inferiorly and anteriorly into the parapharyngeal space and it is in relation- ship with the internal carotid artery medially and with various encephalic nerves as glossopharyngeal, vagus, accessory, hypoglossal .The SP of the temporal bone has a variable length as demonstrated for studies conducted in: three-dimensional com- puted tomography (3dct) or dental panoramic three-dimensional scanning.Sökler" 2248 3034 W4229372335.pdf 0 0 title 0.9892379 1.5. Agreement between observers 0 32 W2889077465.pdf 7 1 separator 0.99291444 ¶ 32 34 W2889077465.pdf 7 2 text 0.7194978 SeeTable 15 . 34 48 W2889077465.pdf 7 3 separator 0.9960989 ¶ 48 50 W2889077465.pdf 7 4 title 0.9913876 2. Experimental design, materials and methods 50 96 W2889077465.pdf 7 5 separator 0.9967027 ¶ 96 98 W2889077465.pdf 7 6 title 0.9751344 2.1. Experimental setup 98 122 W2889077465.pdf 7 7 separator 0.9933298 ¶ 122 124 W2889077465.pdf 7 8 text 0.99935055 "The experimental procedure was approved by the Danish Animal Inspectorate (2013-15-2934- 00849). A total of 12 pigs were anesthetized using the same protocol as recently described [1,7]." 124 313 W2889077465.pdf 7 9 separator 0.8262145 ¶ 313 315 W2889077465.pdf 7 10 text 0.9994807 "During a period of 3 –4 min, four blunt traumas (area of impact Nos. 1, 2, 3 and 4) were in flicted on the back along the right M. longissimus dorsi from the area just caudal to the scapula and to the lumbar region of each pig using a plastic tube (mass 1⁄40.047 kg, impact speed 1⁄447.4 m/s)or an iron bar (mass 1⁄40.4 kg, impact speed 1⁄419.7 m/s) The blunt traumas were in flicted using a mechanical device and procedure as described recently [1,7]. All pigs were kept anesthetized during the experiment and 4 pigs were euthanized every 2, 5 and 8 h after in fliction of trauma ( Fig. 1 )." 315 907 W2889077465.pdf 7 11 separator 0.9974961 ¶ 907 909 W2889077465.pdf 7 12 title 0.99165237 2.2. Histology 909 924 W2889077465.pdf 7 13 separator 0.9969415 ¶ 924 926 W2889077465.pdf 7 14 text 0.99971855 "From each of the areas of impact (Nos. 1 –4), 5 slices of skin and underlying muscle tissue were sampled from the center (B, n1⁄43), the dorsal end (A, n1⁄41) and the ventral end (C, n1⁄41) of the bruises. In addition, uninjured skin and muscle tissue were sampled from the right thigh of each pig and served as control tissue. For histology, the samples were fixed in 10% neutral buffered formalin for up to 5 days [8]. Following fixation, tissue samples were processed through graded concentrations of ethanol and xylene [8]. Tissue sections were cut (4 –5mm) and stained with hematoxylin and eosin before all sections ( n1⁄4240) were blinded and evaluated by a single observer [8]. In addition, 22% of the sections were selected randomly and evaluated by a second observer." 926 1707 W2889077465.pdf 7 15 separator 0.9756716 ¶ 1707 1709 W2889077465.pdf 7 16 text 0.9997185 "In total, 9 histological parameters were assessed [1]. Neutrophils and macrophages were scored on a semiquantitative scale: (0) Absence of neutrophils or macrophages, respectively; (1) 1 –10 neu- trophils or macrophages, respectively; (2) 11 –30 neutrophils or macrophages, respectively; (3) 430 neutrophils or macrophages, respectively. The scoring was carried out in the dermis, subcutaneous fat tissue and muscle tissue in a single high power field at 400 fold magni fication in the area with the highest density of macrophages and neutrophils. In the dermis and muscle tissue, hemorrhage was registered as present or absent. In the subcutis, the density of hemorrhage was registered as the percentile area of extravasated erythrocytes in a low power field at 100 fold magni fication and scored either as (0) absent; (1) minor: o12.5%; (2) moderate: 12.5 –25%; (3) severe 425%. In the muscle tissue, the percentile area of necrosis was evaluated in the area with the highest density of necrotic muscle fibers and scored according to the following scale in a single low power field at 100 fold" 1709 2819 W2889077465.pdf 7 17 paratext 0.7082989 Table 15 2819 2827 W2889077465.pdf 7 18 separator 0.99565214 ¶ 2827 2829 W2889077465.pdf 7 19 text 0.99940187 "Agreement (estimated as Cohen's kappa) between two observers evaluating nine histological parameters in 53 tissue sectionsof skin and muscle selected randomly from a total of 240 tissue sections from experimental bruises. Limits of 95% con fidence interval (Lower95 to Upper95) not including zero and a p-value for kappa below 0.05 means that there is some level of agreement between the two observers. The level of agreement was interpreted according to Altman 1991 [6]." 2829 3304 W2889077465.pdf 7 20 separator 0.99618286 ¶ 3304 3306 W2889077465.pdf 7 21 table 0.9941687 "Tissue Parameter Cohen's kappa Lower95 Upper95 Level of agreement p-value Dermis Neutrophils 0.65 0.51 0.80 Good o0.0001 Dermis Hemorrhage 0.46 0.19 0.73 Moderate 0.0006 Subcutaneous tissue Neutrophils 0.75 0.63 0.87 Good o0.0001 Subcutaneous tissue Macrophages 0.55 0.37 0.74 Moderate o0.0001 Subcutaneous tissue Hemorrhage 0.82 0.71 0.93 Very good o0.0001 Muscle tissue Necrosis 0.89 0.81 0.97 Very good o0.0001 Muscle tissue Neutrophils 0.90 0.83 0.97 Very good o0.0001 Muscle tissue Macrophages 0.84 0.74 0.93 Very good o0.0001 Muscle tissue Hemorrhage 0.84 0.70 0.99 Very good o0.0001K" 3306 3915 W2889077465.pdf 7 22 paratext 0.9863415 . Barington et al. / Data in Brief 20 (2018) 1166 –1176 1173 3915 3975 W2889077465.pdf 7 0 separator 0.61302596 1 2 W4312259627.pdf 1 1 paratext 0.934935 "¶ Copyright : @ 2021 Rosmiati" 1 35 W4312259627.pdf 1 2 separator 0.9170866 ¶ 37 39 W4312259627.pdf 1 3 contact 0.81630236 Rosmiati1, Suryo Pratikwo 2, Arwani3, Mardi Hartono4, Tri Anonim5 39 105 W4312259627.pdf 1 4 separator 0.96249866 ¶ ¶ 106 113 W4312259627.pdf 1 5 title 0.98939914 "THE EFFECT OF HEALTH EDUCATION WITH AUDIOVISUAL MEDIA ON FAMILY KNOWLEDGE IN HANDLING FEVER SEIZURES IN CHILDREN" 113 229 W4312259627.pdf 1 6 separator 0.988609 ¶ ¶ 231 237 W4312259627.pdf 1 7 contact 0.9782301 "Rosmiati1, Suryo Pratikwo 2, Arwani3, Mardi Hartono4, Tri Anonim5 1,2,3 ,4,5Pekalongan Nursing Study Program Polytechnic Health Ministry of Semarang , Indonesia ¶ *Corresponding author : rosmiatisaleh59@gmail.com ¶" 237 463 W4312259627.pdf 1 8 separator 0.7871597 ¶ ¶ 465 471 W4312259627.pdf 1 9 title 0.9871031 ABSTRACT 471 480 W4312259627.pdf 1 10 separator 0.99226725 ¶ ¶ 482 488 W4312259627.pdf 1 11 text 0.9907424 "Background : The level of family knowledge can be the key in handling febrile seizures in children. One way that can be used to increase knowledge is by conducting health education using audiovisual media. " 488 700 W4312259627.pdf 1 12 separator 0.5802319 ¶ 700 701 W4312259627.pdf 1 13 text 0.99957114 "Audiovisual media can provide a stimulus to the two human senses, namely sight and hearing. Health education th at is carried out in a structured and consistent manner can provide effective information for a person." 701 923 W4312259627.pdf 1 14 separator 0.90875983 ¶ 925 927 W4312259627.pdf 1 15 text 0.99811524 "Objective : This study aims to determine the effect of providing audiovisual -based health education to increase family knowledge in handling febrile sei zures in children." 927 1104 W4312259627.pdf 1 16 separator 0.8537332 ¶ 1106 1108 W4312259627.pdf 1 17 text 0.9996492 "Method : This study aims to determine the effect of providing audiovisual -based health education to increase family knowledge in handling febrile seizures in children. This study used a quasi -experimental method with a control group. The control group was given an intervention in the form of traditional health education, while the intervention group was given an intervention in the form of education using audiovisual media. The sampling technique used total sampling by using all responden ts who met the criteria." 1108 1643 W4312259627.pdf 1 18 separator 0.8316635 ¶ 1644 1646 W4312259627.pdf 1 19 text 0.9988171 "Respondents were divided into two groups, namely the control group and the intervention group. Each group contains 20 respondents, namely families with children from 3 months to 5 years ." 1646 1837 W4312259627.pdf 1 20 separator 0.94873416 ¶ 1838 1840 W4312259627.pdf 1 21 text 0.99926615 "Results : The results of this study showed a significant increase in knowledge in the intervention group. In addition, family skills in dealing with febrile seizures in children are also getting better.acquainted." 1840 2059 W4312259627.pdf 1 22 separator 0.95777994 ¶ ¶ 2061 2067 W4312259627.pdf 1 23 paratext 0.5907877 Key words : Audi visual; Knowledge; Febrile convulsion 2067 2123 W4312259627.pdf 1 24 separator 0.71908206 ¶ 2125 2130 W4312259627.pdf 1 25 paratext 0.5735992 ¶ 2130 2131 W4312259627.pdf 1 26 separator 0.7536577 ¶ 2133 2135 W4312259627.pdf 1 27 paratext 0.95476776 "ISSN : 2807 -9280 https://ejournal.poltekkes -smg.ac.id/ojs/index.php/LIK JLK Team" 2135 2226 W4312259627.pdf 1 0 title 0.79150504 Selection of our books indexed in the Book Citation Index 0 57 W1590167984.pdf 0 1 separator 0.43706942 58 59 W1590167984.pdf 0 2 paratext 0.51564527 ¶ in Web of ScienceTM Core Collection (BKCI) 59 102 W1590167984.pdf 0 3 separator 0.9592484 ¶ 102 104 W1590167984.pdf 0 4 contact 0.6887386 Interested in publishing with us? 104 138 W1590167984.pdf 0 5 separator 0.78090066 ¶ 139 141 W1590167984.pdf 0 6 contact 0.9428876 Contact book.department@intechopen.com 141 180 W1590167984.pdf 0 7 separator 0.99162865 ¶ 180 182 W1590167984.pdf 0 8 text 0.77825713 "Numbers displayed above are based on latest data collected. For more information visit www.intechopen.comOpen access books available" 182 318 W1590167984.pdf 0 9 separator 0.98262835 ¶ 318 320 W1590167984.pdf 0 10 title 0.877057 Countries delivered to Contributors from top 500 universitiesInternational authors and editors 320 420 W1590167984.pdf 0 11 separator 0.69781977 ¶ 420 422 W1590167984.pdf 0 12 text 0.9326995 "Our authors are among th e most cited scientistsDownloadsWe are IntechOpen, the world’s leading publisher of Open Access books" 422 556 W1590167984.pdf 0 13 separator 0.84674954 ¶ 556 558 W1590167984.pdf 0 14 text 0.59233 Built by scientist 558 577 W1590167984.pdf 0 15 table 0.535907 s, 577 579 W1590167984.pdf 0 16 text 0.5271973 for 579 583 W1590167984.pdf 0 17 table 0.6914422 scientists 583 594 W1590167984.pdf 0 18 separator 0.6065768 ¶ 594 596 W1590167984.pdf 0 19 table 0.973226 "12.2%186,000 200M TOP 1% 1546,900" 596 632 W1590167984.pdf 0 0 paratext 0.9151327 REINALDO R. ROSA DATA 0 21 W3090022343.pdf 7 1 title 0.6861214 SCIENCE STRATEGIES FOR MULTIMESSENGER ASTRONOMY 21 69 W3090022343.pdf 7 2 separator 0.9814986 ¶ 69 71 W3090022343.pdf 7 3 title 0.98470324 APPENDIX:BIGDATAINASTRONOMY 71 99 W3090022343.pdf 7 4 separator 0.98900735 ¶ 99 101 W3090022343.pdf 7 5 text 0.99945223 "The concept of epistemological paradigm indicates how the advancement of scientific knowledge has evolved over the history of civilization (Kuhn 1996, Tansley & Toole 2009)." 101 281 W3090022343.pdf 7 6 separator 0.5523795 ¶ 281 283 W3090022343.pdf 7 7 text 0.9994944 "According to some important contemporary scientists, science in the 21stcentury is experiencing the shift to a fourth paradigm after a sequence of three: (i) science guided mostly by empirical experiments, (ii) science guided mostly by theory and (iii) science guided mostly by computer simulation. The fourth paradigm suggests that new and more important scientific discoveries are (and will be more and more) strongly conditioned by the intensive use of large volumes of data called Big Data (Kelleher & Tierney 2018). The science driven by big data is the 4thparadigm, interpreted today as Data Scienceby most of the productive and academic sectors." 283 964 W3090022343.pdf 7 8 separator 0.9735554 ¶ 964 966 W3090022343.pdf 7 9 text 0.9995558 "Manyauthorstrytodefine BigData fromthe so-called set of the four basic properties (4V): volume,velocity,varietyandvalue. Properties that are related to the production, transmission, storage, acquisition and analytical manipulation of digital information. In practice, the workfow velocity (in bytes per unit of time) is a veryimportant quantitative factor. In this way, big dataare large data sets that are generally heterogeneous in their variety and value and, therefore, demand great storage and processing power throughout their workflow." 966 1529 W3090022343.pdf 7 10 separator 0.97814465 ¶ 1529 1531 W3090022343.pdf 7 11 text 0.9993301 "Nowadays, the main source of Big Data Workflows is the active network of electronic devices connected to the internet, named by KevinAshton,in1999,bythenameofthe Internet of Things or simply IoT(See Figure 2). In the context of IoT, the search for information or new knowledge, whether working with simulations, measurementsensorsoralreadypublisheddata, is based on large amounts of data that are, for the human brain, very difficult to store, manipulate, analyze and understand. It is in this context that data mining (mostly based on techniques from machine learning ) is one of the fundamental gears in the process of extracting information from big data." 1531 2218 W3090022343.pdf 7 12 separator 0.9753598 ¶ 2218 2220 W3090022343.pdf 7 13 text 0.9995117 "Astronomical observatories generate an impressive amount of data. For example, ALMA (Atacama Large Millimeter Array), operating in Chile, adds about 2 TB of data to its files every day. And as we know, each generation of observatories is usually at least ten times more sensitive than the previous one, either because" 2220 2550 W3090022343.pdf 7 14 separator 0.9358152 ¶ 2550 2552 W3090022343.pdf 7 15 caption 0.99511224 "Figure2. Today, the data life cycle can follow the path defined by data science based entirely on cloud computing. The observer makes use of IoT devices to place their data in the cloud. The IoT is generating Big Data where your data is now inserted. A user can mine the data and extract knowledgedirectlyin thecloud.This knowledgecanservetogeneratenew data and thus boost the cycle." 2552 2946 W3090022343.pdf 7 16 separator 0.9805285 ¶ 2946 2948 W3090022343.pdf 7 17 paratext 0.98799795 An Acad Bras Cienc (2021) 93(Suppl. 1) e20200861 8 | 9 2948 3003 W3090022343.pdf 7 0 paratext 0.98829085 Molecules 2017 ,22, 593 7 of 15 0 31 W2604241522.pdf 6 1 separator 0.98715895 ¶ 31 33 W2604241522.pdf 6 2 title 0.9830942 Table 4. Boltzmann population for rotamers of 3R. 33 83 W2604241522.pdf 6 3 separator 0.9718518 ¶ 83 85 W2604241522.pdf 6 4 table 0.99529636 "Compound E rel(Kcal/mol) % 3Ra 0.87 17.85 3Rb 1.64 4.87 3Rc 0 77.28" 85 159 W2604241522.pdf 6 5 separator 0.7877834 ¶ 159 161 W2604241522.pdf 6 6 paratext 0.82747704 Molecules 2017 , 22, 593 7 of 15 161 194 W2604241522.pdf 6 7 separator 0.99641 ¶ 195 197 W2604241522.pdf 6 8 title 0.81496656 Table 4. Boltzmann population for rotamers of 3R 198 248 W2604241522.pdf 6 9 table 0.5549561 . 248 249 W2604241522.pdf 6 10 separator 0.7784594 ¶ 250 252 W2604241522.pdf 6 11 table 0.9893018 "Compound E rel(Kcal/mol) % 3Ra 0.87 17.85 3Rb 1.64 4.87 3Rc 0 77.28 ¶" 252 331 W2604241522.pdf 6 12 separator 0.6339244 ¶ 333 335 W2604241522.pdf 6 13 caption 0.86497307 Figure 8. Single rotamer for 4S. 335 369 W2604241522.pdf 6 14 separator 0.9942545 ¶ 370 372 W2604241522.pdf 6 15 title 0.84233856 Table 5. Boltzmann population for rotamers of 4S. 372 423 W2604241522.pdf 6 16 separator 0.78487265 ¶ 424 426 W2604241522.pdf 6 17 table 0.9704828 "Compound E rel(Kcal/mol) % 4Sa 0 100.00 4Sb 6.65 0.00 4Sc 6.97 0.00 ¶" 426 509 W2604241522.pdf 6 18 caption 0.83874995 Figure 9. Single rotamer for 4R. 509 543 W2604241522.pdf 6 19 separator 0.9941846 ¶ 544 546 W2604241522.pdf 6 20 title 0.87208235 Table 6. Boltzmann population for rotamers of 4R 546 596 W2604241522.pdf 6 21 table 0.4766378 . 596 597 W2604241522.pdf 6 22 separator 0.7807236 ¶ 598 600 W2604241522.pdf 6 23 table 0.99514806 "Compound E rel(Kcal/mol) % 4Ra 0 99.99 4Rb 5.42 0.01 4Rc 9.19 0.00" 600 675 W2604241522.pdf 6 24 separator 0.9439148 ¶ 676 678 W2604241522.pdf 6 25 text 0.999557 "A different behavior takes place in chromenone derivatives 5 (Figure 10, Table 7) and 6 (Figure 11, Table 8). Compound 5 exhibits two hydrogen bonds in al l calculated structures, the same already discussed before between one phenolic prot on with the carbonyl oxygen atom forming a six membered ring, and a different hydrogen bond between the other phenolic proton and the oxygen atom of the chromenone ring, fo rming a five membered ring. The 1H-NMR spectrum evidences these interactions by displaying chemical shifts of phenolic protons at δ = 5.05 and 11.34 for OH-5 and OH-10, respectively. The conformation of the hydr oxymethyl group here has a similar behavior to that described for compound 1, displaying a mixture of three conformers. The preferred rotamer" 678 1467 W2604241522.pdf 6 26 separator 0.99496514 ¶ 1468 1470 W2604241522.pdf 6 27 caption 0.96076953 Figure 8. Single rotamer for 4S. 1470 1503 W2604241522.pdf 6 28 separator 0.994356 ¶ 1503 1505 W2604241522.pdf 6 29 title 0.92294574 Table 5. Boltzmann population for rotamers of 4S. 1505 1555 W2604241522.pdf 6 30 separator 0.8350192 ¶ 1555 1557 W2604241522.pdf 6 31 table 0.9733113 "Compound E rel(Kcal/mol) % 4Sa 0 100.00 4Sb 6.65 0.00 4Sc 6.97 0.00 ¶" 1557 1633 W2604241522.pdf 6 32 paratext 0.86202043 Molecules 2017 , 22, 593 7 of 15 1633 1666 W2604241522.pdf 6 33 separator 0.9962572 ¶ 1667 1669 W2604241522.pdf 6 34 title 0.8450873 Table 4. Boltzmann population for rotamers of 3R 1670 1720 W2604241522.pdf 6 35 table 0.5178444 . 1720 1721 W2604241522.pdf 6 36 separator 0.7723007 ¶ 1722 1724 W2604241522.pdf 6 37 table 0.96969056 "Compound E rel(Kcal/mol) % 3Ra 0.87 17.85 3Rb 1.64 4.87 3Rc 0 77.28 ¶" 1724 1807 W2604241522.pdf 6 38 caption 0.8257427 Figure 8. Single rotamer for 4S. 1807 1841 W2604241522.pdf 6 39 separator 0.9938654 ¶ 1842 1844 W2604241522.pdf 6 40 title 0.77449954 Table 5. Boltzmann population for rotamers of 4S 1844 1894 W2604241522.pdf 6 41 table 0.6069524 . 1894 1895 W2604241522.pdf 6 42 separator 0.7178743 ¶ 1896 1898 W2604241522.pdf 6 43 table 0.967277 "Compound E rel(Kcal/mol) % 4Sa 0 100.00 4Sb 6.65 0.00 4Sc 6.97 0.00 ¶" 1898 1981 W2604241522.pdf 6 44 caption 0.8889325 Figure 9. Single rotamer for 4R. 1981 2015 W2604241522.pdf 6 45 separator 0.994715 ¶ 2016 2018 W2604241522.pdf 6 46 title 0.86640835 Table 6. Boltzmann population for rotamers of 4R. 2018 2069 W2604241522.pdf 6 47 separator 0.8083465 ¶ 2070 2072 W2604241522.pdf 6 48 table 0.99468267 "Compound E rel(Kcal/mol) % 4Ra 0 99.99 4Rb 5.42 0.01 4Rc 9.19 0.00" 2072 2147 W2604241522.pdf 6 49 separator 0.9383713 ¶ 2148 2150 W2604241522.pdf 6 50 text 0.9995066 "A different behavior takes place in chromenone derivatives 5 (Figure 10, Table 7) and 6 (Figure 11, Table 8). Compound 5 exhibits two hydrogen bonds in al l calculated structures, the same already discussed before between one phenolic prot on with the carbonyl oxygen atom forming a six membered ring, and a different hydrogen bond between the other phenolic proton and the oxygen atom of the chromenone ring, fo rming a five membered ring. The 1H-NMR spectrum evidences these interactions by displaying chemical shifts of phenolic protons at δ = 5.05 and 11.34 for OH-5 and OH-10, respectively. The conformation of the hydr oxymethyl group here has a similar behavior to that described for compound 1, displaying a mixture of three conformers. The preferred rotamer" 2150 2939 W2604241522.pdf 6 51 separator 0.9950057 ¶ 2940 2942 W2604241522.pdf 6 52 caption 0.97775584 Figure 9. Single rotamer for 4R. 2942 2975 W2604241522.pdf 6 53 separator 0.99508977 ¶ 2975 2977 W2604241522.pdf 6 54 title 0.91134566 Table 6. Boltzmann population for rotamers of 4R. 2977 3027 W2604241522.pdf 6 55 separator 0.8415545 ¶ 3027 3029 W2604241522.pdf 6 56 table 0.9941836 "Compound E rel(Kcal/mol) % 4Ra 0 99.99 4Rb 5.42 0.01 4Rc 9.19 0.00" 3029 3102 W2604241522.pdf 6 57 separator 0.94487035 ¶ 3102 3104 W2604241522.pdf 6 58 text 0.99948746 "A different behavior takes place in chromenone derivatives 5(Figure 10, Table 7) and 6(Figure 11, Table 8). Compound 5exhibits two hydrogen bonds in all calculated structures, the same already discussed before between one phenolic proton with the carbonyl oxygen atom forming a six membered ring, and a different hydrogen bond between the other phenolic proton and the oxygen atom of the chromenone ring, forming a five membered ring. The1H-NMR spectrum evidences these interactions by displaying chemical shifts of phenolic protons at = 5.05 and 11.34 for OH-5 and OH-10, respectively." 3104 3701 W2604241522.pdf 6 0 paratext 0.9769579 246 0 3 W4242477029.pdf 0 1 separator 0.81312656 ¶ 3 5 W4242477029.pdf 0 2 title 0.8542312 Testimonium Spiritus Sancti Internum. 5 43 W4242477029.pdf 0 3 separator 0.85856724 ¶ 43 45 W4242477029.pdf 0 4 title 0.8857263 BY PROFESSOR THE REVEREND JAMES STALKER, D.D., ABERDEEN. 45 102 W4242477029.pdf 0 5 separator 0.9880646 ¶ 102 104 W4242477029.pdf 0 6 text 0.9996017 "EARLY in the war there was published in Paris a book by one Pescari, a grandson of M. Renan, the author of The Life of Jesus. It was introduced to the public by a preface from the pen of M. Bourget, who is, I fancy, among the’most eminent of living men of letters in France. And it had the honour of being crowned by the French Academy of Letters. Though issued as a romance, it was understood to contain, under a thin veil, a strongly autobiographical element. It did not deny that the author had been brought up in the sceptical principles of his grandfather, or that, in being launched on the society of literary Paris, he had lived with the freedom too common there." 104 801 W4242477029.pdf 0 7 separator 0.87926745 ¶ 801 803 W4242477029.pdf 0 8 text 0.99968374 "But, becoming a soldier, he was sent out to the part of North Africa in French occupation. Living there in enemy-country, he was disciplined in vigilance and unselfishness by having to consider continually the safety of the men under his charge." 803 1057 W4242477029.pdf 0 9 separator 0.8288845 ¶ 1057 1059 W4242477029.pdf 0 10 text 0.9995882 "Being often on the borders of the Sahara, he acquired habits of meditation, whilst wandering forth from the camp into the safer portions of the surrounding desert. He had always been a reader; but now his reading took a more serious turn, and he became a student of the Bible. One text especially laid hold of his mind-the saying of the centurion who sent for Jesus to come and heal his servant-‘ For I also am a man set under authority, having under me soldiers: and I say unto one, Go, and he goeth ; and to another, Come, and he cometh; and to my servant, Do this, and he doeth it.’ Every action of his daily life threw light on this text, and the text, in turn, threw light on every aspect of the daily routine. It penetrated, however, by degrees far more deeply into his mind; because he seemed to see in it both what the Saviour had done for him and what he might do for the Saviour. When he returned to Paris, he lost no time in letting it be known that he had undergone a spiritual change; and, when his book was published, not only did it exhibit his favourite text on the title-page, but the name it bore was The Journey of the Centurion." 1059 2254 W4242477029.pdf 0 11 separator 0.9803289 ¶ 2254 2256 W4242477029.pdf 0 12 text 0.9996611 "At the outbreak of the war the author was in the camp at Cherbourg, and he was among the first to be sent to the front. But his careerterminated within a fortnight; for he fell in the battle of Rossignol." 2256 2467 W4242477029.pdf 0 13 separator 0.8274038 ¶ 2467 2469 W4242477029.pdf 0 14 text 0.99953514 "I In this incident there are many points of interest; but the one on which I wish to fix attention is the part played in it by a verse of Holy. Writ. In such spiritual crises it is no unusual thing for a Scripture text to discharge what Socrates would have called a maieutic office. Even where the mind may have been sceptical before, the im- pression of a divine evidence seems to sweep all doubts away, without the need of scientific inquiry." 2469 2930 W4242477029.pdf 0 15 separator 0.88213706 ¶ 2930 2932 W4242477029.pdf 0 16 text 0.9993763 "It is as if God ’had revealed Himself suddenly with irresistible and immediate testimony: and thenceforth He speaks not only in the particular text, but in His Word as a whole. This is what is called, in theology, the Testimonium S Sandi Internttm." 2932 3191 W4242477029.pdf 0 17 separator 0.91422546 ¶ 3191 3193 W4242477029.pdf 0 18 text 0.99961054 "This phrase has a sound of mystery; and it certainly belongs to that aspect of religion in which it is described as the secret of the Lord’; yet it ought not to be incapable of theological control." 3193 3397 W4242477029.pdf 0 19 separator 0.9424108 ¶ 3397 3399 W4242477029.pdf 0 20 text 0.9986179 "The object of the present article is to furnish a definition which will bring it within the range of theological science; and I will attempt it in the following form : When the Spirit of God isperforvi- ing any of His characteristic operations in the spirit of man, any text of scripture embodying the truth whicll ought then to be filling the mind is apt to come home with unique force and conviction." 3399 3816 W4242477029.pdf 0 21 separator 0.87597877 ¶ 3816 3818 W4242477029.pdf 0 22 text 0.99917436 "Let this definition be tested. by any of the characteristic works of the Holy Spirit. Of these our Lord Himself supplied a list when He said that the Spirit of Truth, when He came, would convince the world of sin, of righteousness, and of judgment." 3818 4077 W4242477029.pdf 0 23 separator 0.9499993 ¶ 4077 4079 W4242477029.pdf 0 24 text 0.99370986 "First, the conviction of sin. This it is the office of the Holy Spirit to produce, and He may do it through a great variety of means. For days or weeks or years the awakening of the conscience may have been becoming more and more intense. Now, when the mind is in this condition through the operation of the Holy Spirit, any text of Scripture, describing sin as God sees it and setting forth its guilt and punishment, is apt to come home with overwhelming power. ’ Of this we have a memorable instance in the ¶" 4079 4610 W4242477029.pdf 0 0 text 0.9893757 "be seen from Figure 13 , the single step motion resolution of the actuator reaches 96 nm under the locking force of 1 N." 0 122 W4224299041.pdf 15 1 separator 0.97174 ¶ 122 124 W4224299041.pdf 15 2 text 0.9992287 "Maintaining the voltage is 100 V p-p, the displacement characteristics under differ- ent locking forces are plotted, as shown in Figure 14 . It is obvious that the velocity is the fastest at the locking force of 1 N, the friction resistance is small at this time, so the backward motion is minimum. The load characteristics of the actuator is emerged in" 124 484 W4224299041.pdf 15 3 separator 0.8339539 ¶ 484 486 W4224299041.pdf 15 4 text 0.9954864 "Figure 15 , as the locking force gradually increases, the maximum load of the actuator increases significantly. Within a certain adjustment range, the greater locking force can increase the friction driving force, which improves the load capacity of the actuator. It can be seen that the velocity decreases almost linearly with the load increases, and the maximum load mass of the actuator exceeds 330 g under 3 N locking force." 486 925 W4224299041.pdf 15 5 separator 0.974279 ¶ 925 927 W4224299041.pdf 15 6 text 0.9903658 "The efficiency ηis usually introduced to evaluate the output capacity of the actuator, which can be calculated by " 927 1044 W4224299041.pdf 15 7 separator 0.56666887 ¶ 1044 1045 W4224299041.pdf 15 8 text 0.7817178 1045 1046 W4224299041.pdf 15 9 math 0.8340197 "η1⁄4Pout Pin1⁄4F/C2v Pin1⁄4mg/C2v Pin/C2100% (23)" 1046 1095 W4224299041.pdf 15 10 separator 0.9869338 ¶ 1095 1097 W4224299041.pdf 15 11 caption 0.9775154 "Figure 13. The motion resolution under the locking force of 1 N." 1097 1164 W4224299041.pdf 15 12 separator 0.78887415 ¶ 1164 1166 W4224299041.pdf 15 13 caption 0.9547397 "Figure 14. Displacement characteristics under different locking forces." 1166 1240 W4224299041.pdf 15 14 separator 0.99528277 ¶ 1240 1242 W4224299041.pdf 15 15 title 0.9838969 15Topology Optimization Methods for Flexure Hinge Type Piezoelectric Actuators 1242 1321 W4224299041.pdf 15 16 separator 0.939873 ¶ 1321 1323 W4224299041.pdf 15 17 paratext 0.94901365 DOI: http:/ /dx.doi.org/10.5772/intechopen.1 03983 1323 1374 W4224299041.pdf 15 0 paratext 0.9319717 "Journal of Economics and Finance 1 3" 0 38 W4391133625.pdf 21 1 separator 0.9962822 ¶ 38 40 W4391133625.pdf 21 2 text 0.99907684 "In terms of policy, a first indication offered by the present research is that inter - ventions to ensure and consolidate the relations between vulnerable enterprises and banks could be designed. Indeed, establishing and maintaining interactions among these agents might ensure lower fluctuations in firms’ stability, especially those highly indebted. Moreover, our work suggests that restructuring processes oriented to a more concentrated banking system could benefit vulnerable firms. In this vein, the introduction of a recent reform (law 49/2016) about reinforcing and re-centralis- ing the cooperative banks’ system could represent a starting point for future evalua- tion of banking concentration and its effect on enterprises. Similarly, whether and to what extent our conclusions hold by using other firms’ financial stability and indebt- edness measures and employing Artificial Intelligence techniques are relevant topics for future research." 40 1023 W4391133625.pdf 21 3 separator 0.9966763 ¶ 1023 1025 W4391133625.pdf 21 4 title 0.9784985 Appendix 1025 1034 W4391133625.pdf 21 5 separator 0.98916477 ¶ 1034 1036 W4391133625.pdf 21 6 text 0.37529367 Figure 1036 1043 W4391133625.pdf 21 7 caption 0.31851932 s 1043 1044 W4391133625.pdf 21 8 text 0.47710744 3, 4, 5, 6, and 7 1044 1062 W4391133625.pdf 21 9 separator 0.47507447 ¶ 1062 1064 W4391133625.pdf 21 10 text 0.5198332 Tables 8, 9, 10, 11, 12, and 13. 1064 1097 W4391133625.pdf 21 11 separator 0.9940339 ¶ 1097 1099 W4391133625.pdf 21 12 caption 0.99558926 Fig. 3 Marginal effect of LEV on ZSCORE as LEV changes 1099 1155 W4391133625.pdf 21 0 paratext 0.9897537 Int. J. Mol. Sci. 2019 ,20, 4003 3 of 15 0 40 W2967175311.pdf 2 1 separator 0.99286246 ¶ 40 42 W2967175311.pdf 2 2 text 0.99700564 "found for the first time in our study. The deletion was verified through PCR amplification and Sanger sequencing with specific primers rpl32_1F /rpl32_1R (Table S1). The special plastid genome structure of E. chlorandrum suggests that it is di erent from E. acuminatum ." 42 314 W2967175311.pdf 2 3 separator 0.9944713 ¶ 314 316 W2967175311.pdf 2 4 caption 0.9956945 Figure 1. Gene map of the complete plastid genomes of E. wushanense and its closely related species. 316 417 W2967175311.pdf 2 5 separator 0.9618407 ¶ 417 419 W2967175311.pdf 2 6 caption 0.9745001 "Genes drawn inside the circle are transcribed clockwise, whereas those outside are transcribed counterclockwise. The darker gray in the inner circle corresponds to the GC content, whereas the lighter gray corresponds to the AT content." 419 659 W2967175311.pdf 2 0 paratext 0.98749685 Page 11/16 0 10 W4323356164.pdf 10 1 title 0.9260274 Variable Crude Odd Ratio Adjusted Odd Ratio 10 54 W4323356164.pdf 10 2 separator 0.48610502 ¶ 54 56 W4323356164.pdf 10 3 table 0.9823569 "OR (95% CI) p-value AOR (95%CI) p-value Education level At most Secondary 0.5 (0.271 – 0.899) 0.021 1.0 (0.470 – 2.245) 0.946 Graduate 1.0 (0.612 – 1.736) 0.909 1.0 (0.531 – 1.908) 0.985 Postgraduate (ref) - - - - Currently employed Yes 2.2 (1.446 – 3.257) <0.001 0.6 (0.341 – 1.067) 0.083 No (ref) - - When ANC Commenced 1 2.6 (0.343 – 20.199) 0.352 0.6 (0.069 – 4.863) 0.615 2 1.6 (0.203 – 12.028) 0.669 0.7 (0.088 – 6.125) 0.774 3 (ref) - - - - Husbands Education At Most Secondary 0.4 (0.209 – 0.664) 0.001 2.1 (1.005 – 4.437) 0.048 Graduate 0.9 (0.632 – 1.550) 0.963 0.9 (0.529 – 1.613) 0.781 Postgraduate (ref) - - Occupation Professional 3.1 (1.694 – 5.589) <0.001 0.4 (0.219 – 0.794) 0.008 Sales and services 0.9 (0.459 – 1.876) 0.836 1.1 (0.558 – 2.321) 0.722 Other occupations (ref) - - Age (years) 1.0 (0.996 – 1.080) 0.079 1.0 (0.950 – 1.059) 0.921 Adjusted with Age and Number of Children The reference category = Good knowledge of PE" 58 1103 W4323356164.pdf 10 4 separator 0.99236655 ¶ 1103 1105 W4323356164.pdf 10 5 title 0.9814776 Discussion 1105 1116 W4323356164.pdf 10 6 separator 0.99557453 ¶ 1116 1118 W4323356164.pdf 10 7 text 0.99263334 Pregnancy is one of the signi 1118 1148 W4323356164.pdf 10 0 paratext 0.89845103 diagnostics 0 11 W3106656044.pdf 0 1 separator 0.7947352 ¶ 12 14 W3106656044.pdf 0 2 title 0.6763692 Article 14 22 W3106656044.pdf 0 3 separator 0.6988691 ¶ 22 24 W3106656044.pdf 0 4 title 0.9414306 "BCL2 Expression at Post-Induction and Complete Remission Impact Outcome in Acute Myeloid Leukemia" 24 126 W3106656044.pdf 0 5 separator 0.9711611 ¶ 126 128 W3106656044.pdf 0 6 table 0.61788625 128 129 W3106656044.pdf 0 7 contact 0.45960522 Cristina 129 137 W3106656044.pdf 0 8 table 0.5280127 Bilbao- 137 145 W3106656044.pdf 0 9 contact 0.49366683 Siey 145 149 W3106656044.pdf 0 10 table 0.6447459 ro1,2,*, Carlos Rodr íguez-Medina1, 149 184 W3106656044.pdf 0 11 contact 0.51592517 Yanira 184 191 W3106656044.pdf 0 12 table 0.5398047 Florido1, 191 202 W3106656044.pdf 0 13 contact 0.48725402 Ruth 202 206 W3106656044.pdf 0 14 table 0.5822684 "Stuckey1 , María" 206 227 W3106656044.pdf 0 15 contact 0.4828863 Nieves 227 234 W3106656044.pdf 0 16 table 0.51086456 S á 234 238 W3106656044.pdf 0 17 contact 0.506188 ez1 238 241 W3106656044.pdf 0 18 table 0.60381246 , 241 242 W3106656044.pdf 0 19 contact 0.53187525 Santiago S ánchez 242 260 W3106656044.pdf 0 20 table 0.47347444 - 260 261 W3106656044.pdf 0 21 contact 0.57589155 Sosa 261 265 W3106656044.pdf 0 22 table 0.5139588 "1 ," 265 270 W3106656044.pdf 0 23 contact 0.5881665 Jesús Mar ía Gonz ález Mart ín3 270 302 W3106656044.pdf 0 24 table 0.4502357 302 303 W3106656044.pdf 0 25 contact 0.5111028 ¶ 303 304 W3106656044.pdf 0 26 table 0.55010587 , ¶ 304 308 W3106656044.pdf 0 27 contact 0.5732992 Guillermo Santana1 308 327 W3106656044.pdf 0 28 table 0.5877477 , 327 328 W3106656044.pdf 0 29 contact 0.5708569 Elena Gonz 328 339 W3106656044.pdf 0 30 table 0.4948967 339 340 W3106656044.pdf 0 31 contact 0.5318434 ález-Pérez1 340 351 W3106656044.pdf 0 32 table 0.47014973 , 351 352 W3106656044.pdf 0 33 contact 0.67805785 "Nayl én Cruz-Cruz1, Rosa Fern ández4, Teresa Molero Labarta1,5and Mar ía Teresa Gomez-Casares1,5" 352 451 W3106656044.pdf 0 34 separator 0.9815438 ¶ 451 453 W3106656044.pdf 0 35 contact 0.9962711 "1Molecular Biology Group, Hematology Department, Hospital Universitario de Gran Canaria Dr. Negr ín, 35019 Las Palmas de Gran Canaria, Spain; hematocritico@yahoo.es (C.R.-M.); floryyana@hotmail.com (Y.F.); rstuckey@funcanis.es (R.S.); marysnow@telefonica.net (M.N.S.); jsanchez@fciisc.es (S.S.-S.); gsansan.2@hotmail.com (G.S.); gpelena88@gmail.com (E.G.-P .); nelyan@hotmail.com (N.C.-C.); tmollab@gobiernodecanarias.org (T.M.L.); mgomcasf@gobiernodecanarias.org (M.T.G.-C.)" 453 936 W3106656044.pdf 0 36 separator 0.9393435 ¶ 936 938 W3106656044.pdf 0 37 contact 0.9929738 "2Morphology Department, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain" 938 1047 W3106656044.pdf 0 38 separator 0.552761 ¶ 1047 1049 W3106656044.pdf 0 39 contact 0.9851206 "3Unidad de Investigaci ón, Hospital Universitario de Gran Canaria Dr. Negr ín, 35019 Las Palmas de Gran Canaria, Spain; josu.estadistica@gmail.com 4Hematology Department, Complejo Hospitalario Universitario Insular Materno Infantil, 35016 Las Palmas de Gran Canaria, Spain; rfermarc@hotmail.com" 1049 1350 W3106656044.pdf 0 40 separator 0.5230755 ¶ 1350 1352 W3106656044.pdf 0 41 contact 0.99427336 "5Medical Science Department, Universidad de Las Palmas de Gran Canaria, 35001 Las Palmas de Gran Canaria, Spain" 1352 1466 W3106656044.pdf 0 42 separator 0.5182841 1466 1467 W3106656044.pdf 0 43 contact 0.98228616 ¶ *Correspondence: bilbaocristina@gmail.com; Tel.: +34-928-449420; Fax: +34-928-449827 1467 1553 W3106656044.pdf 0 44 separator 0.9484465 ¶ 1553 1555 W3106656044.pdf 0 45 paratext 0.97592133 "Received: 15 October 2020; Accepted: 3 December 2020; Published: 4 December 2020 /gid00030/gid00035/gid00032/gid00030/gid00038/gid00001/gid00033/gid00042/gid00045 /gid00001 /gid00048/gid00043/gid00031/gid00028/gid00047/gid00032/gid00046" 1555 1796 W3106656044.pdf 0 46 separator 0.9951783 ¶ 1796 1798 W3106656044.pdf 0 47 text 0.9933974 "Abstract: Advances in acute myeloid leukemia (AML) genomics and targeted therapies include the recently approved BCL2 inhibitor venetoclax. The association between BCL2 expression and patient outcome was analyzed in a series of 176 consecutive AML patients at diagnosis (Dx), post-induction (PI), complete remission (CR) and relapse (RL). Levels increased significantly at relapse (mean 1.07 PI /0.96 CR vs. 2.17 RL, p=0.05/p=0.03). In multivariate analysis, high BCL2 -Dx were marginally associated with worse progression-free survival, while high PI levels or at CR had an independent negative impact on outcome (PI: HR 1.58, p=0.014; CR: HR 1.96, p=0.008). This behavior of high PI or CR BCL2 levels and increased risk was maintained in a homogeneous patient subgroup of age <70 and intermediate cytogenetic risk (PI: HR 2.44, p=0.037; CR: HR 2.71, p=0.049). Finally, for this subgroup, high BCL2 at relapse indicated worse overall survival (OS, HR 1.15, p=0.05). In conclusion, high BCL2 levels PI or at CR had an independent negative impact on patient outcome. Therefore, BCL2 expression is a dynamic marker that may be useful during AML patient follow up, andBCL2 levels at PI and /or CR may influence response to anti-BCL2 therapy." 1798 3059 W3106656044.pdf 0 48 separator 0.96907306 ¶ 3059 3061 W3106656044.pdf 0 49 text 0.572532 "Keywords: acute myeloid leukemia; BCL2 inhibitors; biomarkers; patient outcome; induction therapy; molecular diagnostics" 3061 3184 W3106656044.pdf 0 50 separator 0.996245 ¶ 3184 3186 W3106656044.pdf 0 51 title 0.98378974 1. Introduction 3186 3202 W3106656044.pdf 0 52 separator 0.99482334 ¶ 3202 3204 W3106656044.pdf 0 53 text 0.99699 "Advances in acute myeloid leukemia (AML) genomics have revealed the broad biological heterogeneity of the disease, leading to new risk stratifications in the pathology and the incorporation of targeted therapies for a more personalized management [ 1–3]. Despite this progress in the understanding" 3204 3505 W3106656044.pdf 0 54 separator 0.96189576 ¶ 3505 3507 W3106656044.pdf 0 55 paratext 0.9827516 Diagnostics 2020 ,10, 1048; doi:10.3390 /diagnostics10121048 www.mdpi.com /journal /diagnostics 3507 3603 W3106656044.pdf 0 0 title 0.74741364 Ladouceur 0 9 W2155940586.pdf 2 1 text 0.99832755 "Cognitive-affective interactions in adolescence positively valenced stimuli; such an effect was not present in the groups with affective disorders ( Ladouceur et al., 2005 ). Recent neuroimaging studies using cognitive-affective tasks with fMRIin youth with anxiety and mood disorders have reported alter- ations in the functioning of VLPFC and amygdala, suggesting that VLPFC modulation of amygdala may contribute to affectivebiases reported in these clinical populations ( Monk et al., 2008; Pavuluri et al., 2008 ). Together, these findings suggest that using cognitive-affective tasks such as the emotional working mem-ory paradigm enables researchers to investigate the development of attentional control processes (implicated in resisting interfer- ence from emotionally salient distracters) and examine to whatextent the development of the neural systems that support these processes may be altered in youth at risk for or diagnosed with affective disorders." 9 996 W2155940586.pdf 2 2 separator 0.9828514 ¶ 996 998 W2155940586.pdf 2 3 text 0.999755 "Some researchers have also examined the influence of incen- tives on cognitive processes. For instance, using an emotional antisaccade task, Geier and colleagues reported differences inperformance and associated neural activation in fronto-striatal regions in adolescents relative to adults ( Geier et al., 2010 ). An antisaccade is an eye movement to the opposite direction of asuddenly appearing target. This movement requires inhibiting a prepotent response to the target, and the initiation of an alter- nate goal-relevant response in the opposite direction signaled bythe sudden onset of the stimulus. Geier and colleagues examined the effects of reward on antisaccades, during the cue stage, sac- cade preparation stage, and saccade execution stage. In order toassess neural responses across these three stages, a time-course analysis over 18 s post-trial onset was employed. They reported greater ventral striatum activity to the saccade preparation in ado-lescents than adults but during the incentive cue, it was recruited more strongly in adults than adolescents; there were no group differences in the saccade execution stage. Neural regions com-monly recruited during antisaccade were generally less activated in adolescents than adults in response to neutral trials and showed no age-group differences to reward trials. Interestingly, how- ever, this study demonstrated that adolescents tended to exhibit greater recruitment of reward circuitry during saccade prepara-tion to incentive trials. These fi ndings are consistent with those of another recent study in which adolescents exhibited greater activation in reward circuitry and prefrontal regions than adultson a continuous performance task (CPT) ( Smith et al., 2011 ). In this study, Smith and colleagues compared, in adolescents relative to adults, behavioral performance and neural activity on threetypes of trials (non-targets, rewarded targets, and on-rewarded targets) of CPT. Findings from behavioral data analyzes revealed that adolescents responded significantly faster to rewarded vs.non-rewarded targets whereas no such differences were observed in adults. These behavioral findings suggest that being rewarded had significant impact on sustained attention in adolescents thanadults. Moreover, findings from fMRI analyses revealed a sig- nificant positive correlation between age and neural activity to rewarded (vs. non-rewarded) targets in neural regions implicatedin sustained attention (e.g., dorsolateral prefrontal cortex, ven- tromedial orbital frontal cortex), suggesting that age modulated the effects of reward on activity in neural regions implicated insustained attention.In sum, these findings suggest that cognitive control may be more challenged in the face of emotionally salient or incentive- laden distracters in adolescents relative to adults. We acknowledgethat our review of cognitive-affective findings in adolescence was not exhaustive. The purpose was not to provide an exhaustive lit- erature review since this has been accomplished elsewhere (e.g.,Mueller, 2011 ). Rather the aim was to provide some examples of research findings demonstrating that the influence of emotionally salient information on the functioning of neural systems sup-porting cognitive processes including cognitive control undergo important neuro-maturational changes in adolescence. In this review, I will demonstrate that the onset of puberty is associ-ated with increased reactivity to emotionally salient information in ways that create challenges for cognitive control systems." 998 4623 W2155940586.pdf 2 4 separator 0.96485114 ¶ 4623 4625 W2155940586.pdf 2 5 text 0.99976045 "Furthermore, these pubertal influences on fronto-limbic systemsmay be associated with reduced modulation of attention in the context of emotional distracters and increased vulnerability to emotion dysregulation. Such a framework complements existingneurobiological models of adolescent brain development ( Casey et al., 2010; Ernst et al., 2011 ) but attempts to move beyond age- related effects to focus more specifically on neurodevelopmentalchanges occurring at puberty and how such changes may help explain increases in the escalating rates of adolescent death and disability related to problems of emotion regulation (e.g., mooddisorders, suicide, accidents, etc.)." 4625 5306 W2155940586.pdf 2 6 separator 0.9954709 ¶ 5306 5308 W2155940586.pdf 2 7 title 0.98058563 "WHAT DEVELOPMENTAL FACTORS MIGHT INFLUENCE COGNITIVE-AFFECTIVE PROCESSES?" 5308 5384 W2155940586.pdf 2 8 separator 0.768552 ¶ 5384 5386 W2155940586.pdf 2 9 title 0.9852961 RISE IN SEX HORMONES DURING PUBERTY 5386 5422 W2155940586.pdf 2 10 separator 0.99042404 ¶ 5422 5424 W2155940586.pdf 2 11 text 0.9997468 "Puberty refers to a specific set of processes implicating changes in physical and reproductive maturation. Although the majority of these changes occur early to mid-adolescence, as described below, some (e.g., adrenarche and luteinizing hormone secretion), how-ever, can start in childhood. As such, puberty is often considered as the beginning of adolescence, a developmental period between childhood and adulthood that encompasses changes at multiple levels. This transitional developmental period not only implicates changes associated with pubertal maturation but also changesin physical growth, psychological functioning, and social expe- riences ( Dahl and Spear, 2004; Dorn et al., 2006 )." 5424 6136 W2155940586.pdf 2 12 separator 0.9341018 ¶ 6136 6138 W2155940586.pdf 2 13 text 0.99910545 "Puberty includes important changes in the functioning of the neuroendocrine system (for a review, see Dorn et al., 2006; Natsuaki et al., 2009; Blakemore et al., 2010 ). The earliest phase of puberty or “prepuberty,” which begins between 6–9 yearsold in girls and about 1 year later in boys ( Cutler et al., 1990; Parker, 1991 ), involves the rising of androgens that are secreted by the adrenal glands. These include dehydroepiandrosterone(DHEA), its sulfate (DHEAS), and androstendione ( Grumbach and Styne, 2003 ). The rising of these hormones refers to what is known as the beginning of adrenarche . The maturation of pri- mary sexual characteristics (i.e., ovaries and testes) and the full development of secondary sexual characteristics (i.e., pubic hair, breast, and genital development) is associated with the activa-tion of the hypo-thalamic-pituitary gonadal (HPG) axis ( Demir et al., 1996; Delemarre-Van De Waal, 2002 ). The rising of these sexual hormones represents a second phase of puberty knownasgonadarche , which begins at about 9–10 years old in girls and ¶" 6138 7240 W2155940586.pdf 2 14 paratext 0.98483485 Frontiers in Integrative Neuroscience www.frontiersin.org August 2012 | Volume 6 | Article 65 |3 7240 7337 W2155940586.pdf 2 0 paratext 0.97583026 R. Velmurugan et al / Modal analysis of pre and post impacted nano composite laminates 21 0 89 W2169736932.pdf 12 1 separator 0.99584794 ¶ 89 91 W2169736932.pdf 12 2 caption 0.9955994 Figure 15 Post impact damping factors for eight layer laminate subjected to 35 m/s. 91 175 W2169736932.pdf 12 3 separator 0.9925244 ¶ 175 177 W2169736932.pdf 12 4 text 0.9988945 "nano clay and the clay has participated in the load sharing. Figure 19 shows fracture surface of epoxy-glass fiber with 5% clay when subjected to 85 m/s. Complete brittle failure of both fiber and matrix is observed. This is due to the aggolerimation of clay particles leading to weak bonding between the matrix and clay." 177 503 W2169736932.pdf 12 5 separator 0.9944192 ¶ 503 505 W2169736932.pdf 12 6 caption 0.99538106 "Figure 16 SEM of fracture surface of 3 layer laminate without clay subjected to 85 m/s." 505 597 W2169736932.pdf 12 7 separator 0.9733003 ¶ 597 599 W2169736932.pdf 12 8 caption 0.9955205 "Figure 17 SEM of fracture surface of 3 layer laminate with 1% clay subjected to 85 m/s." 599 691 W2169736932.pdf 12 9 separator 0.9962654 ¶ 691 693 W2169736932.pdf 12 10 title 0.9942248 3.3 Comparision of frequency and damping factor for pre and post impacted laminates 693 777 W2169736932.pdf 12 11 separator 0.9958272 ¶ 777 779 W2169736932.pdf 12 12 text 0.99941474 "The experimental natural frequencies for pre and post impacted laminates are compared and the results for Mode I of three layer laminates are shown in Fig.20. In mode I, the natural frequency of laminate without clay, after 82 m/s velocity of impact, is 11.6% less compared to pre impacted specimens. In mode V the natural frequency is about 19% less when compared" 779 1150 W2169736932.pdf 12 13 separator 0.99564874 ¶ 1150 1152 W2169736932.pdf 12 14 paratext 0.98413074 Latin American Journal of Solids and Structures 8(2011) 9 – 26 1152 1215 W2169736932.pdf 12 0 paratext 0.98299724 Page 7/29 0 9 W4393236140.pdf 6 1 text 0.98849446 "growth, 4 × 10^6 CWR22Rv1 cells (sgControl, sgPLXND1#1, or sgPLXND1#2) were combined in a 1:1 ratio with Matrigel (Corning) for bilateral subcutaneous injection into NSG mice. Tumor size was measured every 3–4 days with calipers, and tumor volume was calculated as width^2 × length × 0.52, starting one week after tumor inoculation." 9 347 W4393236140.pdf 6 2 separator 0.96771157 ¶ 347 349 W4393236140.pdf 6 3 text 0.9978643 "For organoid culture, PDX tumor tissues were collected and cut into 2–4 mm3. Tumors were digested using collagenase IV (STEMCELL) and incubated at 37°C for 30 min until tumor cells were dispersed." 349 548 W4393236140.pdf 6 4 separator 0.9035252 ¶ 548 550 W4393236140.pdf 6 5 text 0.99689144 "Advanced DMEM (ADMEM) medium supplemented with 1× GlutaMAX (Gibco), 1M HEPES (Gibco), 100 u/ml penicillin, and 0.1 mg/ml streptomycin was added to the cell suspension and then" 550 728 W4393236140.pdf 6 0 text 0.9711515 "Technology Innovation Management (TIM; timprogram.ca) is an international master's level program at Carleton University in Ottawa, Canada. It leads to a Master of Applied Science (M.A.Sc.) degree, a Master of Engineering (M.Eng.) degree, or a Master of Entrepreneurship (M.Ent.) degree. The objective of this program is to train aspiring entrepreneurs on creating wealth at the early stages of company or opportunity lifecycles. • The TIM Review is published in association with and receives partial funding from the TIM program." 0 552 W2777697578.pdf 3 1 title 0.98779804 Academic Affiliations and Funding Acknowledgements 552 602 W2777697578.pdf 3 2 separator 0.9952046 ¶ 602 604 W2777697578.pdf 3 3 text 0.9911495 "The Federal Economic Development Agency for Southern Ontario (FedDev Ontario; feddevontario.gc.ca) is part of the Innovation, Science and Economic Development portfolio and one of six regional development agencies, each of which helps to address key economic challenges by providing regionally- tailored programs, services, knowledge and expertise. • The TIM Review receives partial funding from FedDev Ontario's Investing in Regional Diversification initiative.timreview.ca" 604 1098 W2777697578.pdf 3 4 separator 0.99125886 ¶ 1098 1100 W2777697578.pdf 3 5 title 0.79005635 Technology Innovation 1100 1122 W2777697578.pdf 3 6 separator 0.7871682 ¶ 1122 1124 W2777697578.pdf 3 7 title 0.6627401 Management Review 1124 1142 W2777697578.pdf 3 0 title 0.99141765 B. Simulation Setup 0 19 W4309957174.pdf 5 1 separator 0.995385 ¶ 19 21 W4309957174.pdf 5 2 text 0.9993953 "We adopt the simulation setup for coverage extension de- picted in [14, Fig. 1] with the following default values for the parameters [5], [13], [14]. The BS has a 4×4 = 16 UPA whose center is at [30, 0, 10] m. The RIS is a UPA whose center is at [0, 50, 5] m which consists of Ny×Nzsquare tiles along the y- and z-axes, respectively. The element spacing of the UPAs at both BS and RIS is half wavelength. The UEs have a single antenna and their positions are randomly generated on a 8m×8m square area with center [10, 50, 1] m." 21 565 W4309957174.pdf 5 3 separator 0.6741222 ¶ 565 567 W4309957174.pdf 5 4 text 0.9970868 "The noise variance is computed as σ2 n=WN 0Nfwith N0=−174 dBm/Hz, W= 20 MHz, and Nf= 6 dB. We assume 5GHz carrier frequency, β=−46dB at d0= 1 m, andγthr= 10 . Moreover, we adopt η= (3.5, 2, 2.8) and K= (0, 10, 1) for the BS-UE, BS-RIS, and RIS-UE channels, respectively. Except for the i.i.d Rayleigh fading model, LOS is assumed for the BS-RIS and RIS-UE links. For each channel, we generate L= 5 clusters and R= 20 subpaths (i.e., 100 channel paths for each link or 100×(2NUE+ 1) paths in total). The clusters for the BS-UE, BS-RIS, and RIS-UE channels are randomly generated in volumes Vs= {(x,y,z)|x∈[0, 40] m,y∈[0, 60] m,z∈[0, 10] m}, {(x,y,z)|x∈[0, 40] m,y∈[0, 50] m,z∈[0, 10] m}, and {(x,y,z)|x∈[0, 40] m,y∈[40, 60] m,z∈[0, 10] m}, respec- tively. The paths within each cluster are generated in a cube of volume 23m3. The simulation results are averaged over 1000 independent realizations of the channels and UE positions." 567 1531 W4309957174.pdf 5 5 separator 0.99715143 ¶ 1531 1533 W4309957174.pdf 5 6 title 0.9926796 C. Simulation Results 1533 1555 W4309957174.pdf 5 7 separator 0.9962677 ¶ 1555 1557 W4309957174.pdf 5 8 text 0.99075645 "Figs. 1 and 2 show the required BS transmit power Ptx vs. the number of RIS elements QforNUE= 2 when the algorithms in [5] and Algorithm 1 are adopted, respectively." 1557 1727 W4309957174.pdf 5 9 separator 0.80690277 ¶ 1727 1729 W4309957174.pdf 5 10 text 0.9995716 "Due to the high complexity of the algorithm in [5], only up to Q= 128 RIS elements are considered. Moreover, although a large pathloss exponent is assumed for the BS-UE link, extensive simulation experiments have revealed that the impact of the considered RIS is negligible unless the BS-UE link is further attenuated due to, e.g., a blockage. Therefore, we consider a weak BS-UE link with ̄hBL=−40dB. For this setup, Fig. 1 shows that the required BS transmit power is significantly lower for i.i.d. Rayleigh fading than the other models. For half-wavelength element spacing, the performance of i.i.d. Rician and correlated fading is similar which is due to the small correlation of the channel coefficients in this case. Interestingly, while Fig. 1 shows that the algorithm in [5] yields the largest transmit power for the geometric fading models1, Fig. 2 reveals that the proposed Algorithm 1 requires a much smaller transmit power for the geometric fading models despite its lower computational complexity compared to the algorithm in [5]. This is due to the fact that the Algorithm 1 explicitly exploits the ray propagation structure of the underlying channel, i.e., the reflection codebook enables reflection in the desired directions by each tile and the phase wavefront codebook controls the constructive or destructive superposition of the waves reflected by all tiles." 1729 3152 W4309957174.pdf 5 11 separator 0.8486541 ¶ 3152 3154 W4309957174.pdf 5 12 text 0.9995435 "The results obtained with the proposed Algorithm 1 for large RIS (i.e., Q≥128) are reported in Fig. 3. In addition, for 1The amplitude taper in (16) can be potentially incorporated into some of the other channel models, too. Therefore, for a fair comparison, we only include the impact of wavefront curvature in (16) for the reported simulations.comparison, we show the results for two baselines without the RIS, namely obstructed and unobstructed BS-UE links." 3154 3625 W4309957174.pdf 5 13 separator 0.9045826 ¶ 3625 3627 W4309957174.pdf 5 14 text 0.99955755 "This figure suggests that even for the considered relatively rich scattering channel with overall 500paths, several thousands of RIS elements are required to generate a link that is as strong as the unobstructed BS-UE link." 3627 3857 W4309957174.pdf 5 15 separator 0.9747578 ¶ 3857 3859 W4309957174.pdf 5 16 text 0.9980622 "Fig. 4 shows the BS transmit power Ptxvs. the number of UEs NUEforQ= 1024 and Algorithm 1. This figure reveals that compared to i.i.d. Rayleigh fading, a much smaller transmit power is required for the other considered channel models when a single user is assumed. This is mainly due to the strong LOS component assumed for the BS-RIS channel which is missing in the i.i.d. Rayleigh model. However, the required transmit power significantly increases for multiple users, since in this case, the weak non-LOS components of the BS-RIS channel has to be used to convey information." 3859 4456 W4309957174.pdf 5 17 separator 0.82581973 ¶ 4456 4458 W4309957174.pdf 5 18 text 0.9995405 "Furthermore, the models based on isotropic scattering predict a moderate increase of PtxasNUEincreases whereas the geometric channel models suggest a significant increase in the required Ptxdue to the limited number of resolvable channel paths." 4458 4711 W4309957174.pdf 5 19 separator 0.9968251 ¶ 4711 4713 W4309957174.pdf 5 20 title 0.9930642 V. C ONCLUSIONS 4713 4729 W4309957174.pdf 5 21 separator 0.9960897 ¶ 4729 4731 W4309957174.pdf 5 22 text 0.9974206 "In this paper, we have reviewed five channel models that were chosen to progressively improve the modeling accuracy for large RISs. Our simulation experiments for these channel models have revealed important insights for system design. For instance, while for most scenarios, an idealistic rich scattering environment yields a higher system performance, the pro- posed RIS configuration algorithm is able to achieve a higher performance in the finite scattering case for large RISs by explicitly exploiting the underlying geometric characteristics of wave propagation. Moreover, our results have shown that in realistic channel conditions, an extremely large RIS is required to approach the performance of an unobstructed direct link. Furthermore, in a channel with finite scattering objects, the number of UEs that can be simultaneously served by one RIS is quite limited." 4731 5633 W4309957174.pdf 5 23 separator 0.9969338 ¶ 5633 5635 W4309957174.pdf 5 24 title 0.9711413 "APPENDIX A PROOF OF LEMMA 1" 5635 5665 W4309957174.pdf 5 25 separator 0.99531186 ¶ 5665 5667 W4309957174.pdf 5 26 text 0.99886084 "Under Assumptions A1 and A2, the distribution of each entry of HnLOSapproaches a Gaussian distribution as L→ ∞ following the central limit theorem [11]. A matrix Gaussian distribution, MCN (M,αU,βV), is defined three parameters:" 5667 5902 W4309957174.pdf 5 27 separator 0.9175954 ¶ 5902 5904 W4309957174.pdf 5 28 math 0.9100167 "M≜E HnLOS ,U≜E (HnLOS−M)(HnLOS−M)H , andV≜E (HnLOS−M)H(HnLOS−M) ¶" 5904 5988 W4309957174.pdf 5 29 text 0.8999628 ", where ar- bitrary non-negative scalars αandβare chosen such that αβ= 1/E" 5988 6067 W4309957174.pdf 5 30 math 0.60088086 {∥ 6067 6069 W4309957174.pdf 5 31 text 0.522005 Hn 6069 6071 W4309957174.pdf 5 32 math 0.54709655 LOS−M∥2 6071 6078 W4309957174.pdf 5 33 text 0.9654464 "¶ F}[11]. First, we have mean matrix M=0, since E{c(l)}= 0,∀l. The second-order moment matrix Ucan be computed as follows" 6078 6204 W4309957174.pdf 5 34 separator 0.9701947 ¶ 6204 6206 W4309957174.pdf 5 35 math 0.95439285 "U≜E HnLOS(HnLOS)H (a)=1 LLX l=1E c(l)(c(l))∗ ×En arx(Ψ(l) rx)aH tx(Ψ(l) tx)atx(Ψ(l) tx)aH rx(Ψ(l) rx)o =σ2 c LLX l=1En aH tx(Ψ(l) tx)atx(Ψ(l) tx)o En arx(Ψ(l) rx)aH rx(Ψ(l) rx)o" 6206 6440 W4309957174.pdf 5 0 paratext 0.98789865 Minerals 2024 ,14, 454 5 of 9 0 29 W4395668730.pdf 4 1 separator 0.99000967 ¶ 29 31 W4395668730.pdf 4 2 text 0.9986211 "acid, which potentially alters the carbon isotopic compositions of study samples. Further, given that digesting speleothem carbonate by using orthophosphoric acid is a priority step before oxidizing DOC in speleothem, the same results from this conditional experiment suggest that the digestion reaction itself would not affect the δ13CDOC of the study samples." 31 399 W4395668730.pdf 4 3 separator 0.9898627 ¶ 399 401 W4395668730.pdf 4 4 paratext 0.9889257 Minerals 2024 , 14, 454 5 of 9 401 433 W4395668730.pdf 4 5 separator 0.9602617 ¶ ¶ 434 440 W4395668730.pdf 4 6 text 0.99919593 "orthophosphoric acid with an average value of −26.6‰ are equivalent to those of samples without orthophosphoric acid solution (Figure 2), indicating the e ffects of adding acid can be neglected. It also rules out the possibility of contamination from DOC in orthophos- phoric acid, which potentially alters the carbon isotopic compositions of study samples. Further, given that digesting speleothem ca rbonate by using orthophosphoric acid is a priority step before oxidizing DOC in speleo them, the same results from this conditional experiment suggest that the digestion reaction itself would not a ffect the δ 13CDOC of the study samples." 441 1100 W4395668730.pdf 4 7 separator 0.9881127 ¶ ¶ 1101 1107 W4395668730.pdf 4 8 caption 0.9966848 "Figure 2. The δ13CDOC results from a comparison between samples with and without orthophos- phoric acid. The green and blue dashed lines re present the average values of without and with orthophosphoric acid, respectively." 1107 1336 W4395668730.pdf 4 9 separator 0.9930476 ¶ 1338 1340 W4395668730.pdf 4 10 text 0.99944013 "On account of speleothem, carbonate subsam ples need to be completely digested, and hence, enough reaction time is essential. Generally, according to di fferent concentra- tions of DOC in various speleothems, 100–500 mg of carbonate should be prepared so that enough gas CO 2 reaches the limitation for detecting δ13CDOC [9,15]. Previous tests sug- gested a digestion time of 48 h is generally en ough [15], therefore we set 0, 48 h, and 72 h (digestion time occasionally may exceed 48 h) to inspect whether the digestion time a ffects the δ13CDOC of study samples." 1340 1921 W4395668730.pdf 4 11 separator 0.9127475 ¶ 1922 1924 W4395668730.pdf 4 12 text 0.9992615 "The results show that there is a good consistency between 0, 48, and 72 h (Figure 3), indicating that digestion time does not obviously a ffect the δ13CDOC, and the solution still preserves the imprint of the original materials." 1924 2158 W4395668730.pdf 4 13 separator 0.9949641 ¶ 2160 2162 W4395668730.pdf 4 14 caption 0.9966036 "Figure 2. The δ13CDOC results from a comparison between samples with and without orthophos- phoric acid. The green and blue dashed lines represent the average values of without and with orthophosphoric acid, respectively." 2162 2388 W4395668730.pdf 4 15 separator 0.99200034 ¶ 2388 2390 W4395668730.pdf 4 16 text 0.9994758 "On account of speleothem, carbonate subsamples need to be completely digested, and hence, enough reaction time is essential. Generally, according to different concentrations of DOC in various speleothems, 100–500 mg of carbonate should be prepared so that enough gas CO 2reaches the limitation for detecting δ13CDOC [9,15]. Previous tests suggested a digestion time of 48 h is generally enough [ 15], therefore we set 0, 48 h, and 72 h (digestion time occasionally may exceed 48 h) to inspect whether the digestion time affects the δ13CDOC of study samples." 2390 2960 W4395668730.pdf 4 17 separator 0.9113102 ¶ 2960 2962 W4395668730.pdf 4 18 text 0.99909574 "The results show that there is a good consistency between 0, 48, and 72 h (Figure 3), indicating that digestion time does not obviously affect the δ13CDOC, and the solution still preserves the imprint of the original materials." 2962 3194 W4395668730.pdf 4 19 separator 0.9917917 ¶ 3194 3196 W4395668730.pdf 4 20 paratext 0.98742354 Minerals 2024 , 14, 454 6 of 9 3196 3228 W4395668730.pdf 4 21 separator 0.97835016 "¶ ¶" 3229 3240 W4395668730.pdf 4 22 caption 0.9964122 "Figure 3. The δ13CDOC results of di fferent digestion durations. The green, blue, and pink dashed lines represent the average values of di fferent durations respectively." 3240 3412 W4395668730.pdf 4 23 separator 0.99556565 ¶ 3414 3416 W4395668730.pdf 4 24 title 0.9898734 4. Discussion 3416 3430 W4395668730.pdf 4 25 separator 0.9890281 ¶ 3431 3433 W4395668730.pdf 4 26 title 0.99182934 4.1. The Possibilities of Contamination 3433 3473 W4395668730.pdf 4 27 separator 0.9946252 ¶ 3474 3476 W4395668730.pdf 4 28 text 0.9997162 "Exogenous carbon contamination is the culprit behind the unreliable data; hence, clarifying the possibilities of contamination is essential. Blank bears the brunt and needs to be checked, and each step needs to be judged on whether the contaminations appear." 3476 3742 W4395668730.pdf 4 29 separator 0.75443816 ¶ 3743 3745 W4395668730.pdf 4 30 text 0.9996643 "The above results have shown that there is no deviation of δ13CDOC during the digestion process and under the di fferent reaction times, indicating the organic contamination car- bon can be neglected or the content of contamination is not enough to a ffect the δ13CDOC of the study samples." 3745 4043 W4395668730.pdf 4 31 separator 0.68760693 ¶ 4044 4046 W4395668730.pdf 4 32 text 0.99971074 "In addition, it is well known that samples wi th a higher content of carbon are less sus- ceptible to their carbon isotope composition from exogenous contamination because, even if there is contamination, its proportion is re latively low. The opposite is true for samples with low carbon content. Specifically, if th ere is contamination with carbon, the final δ13CDOC could increase or decrease with the decrease in carbon mass in the study samples. To further clarify the possibilities of contamination, we therefore compared the mass of carbon in dif- ferent samples and their δ13CDOC. The comparison shows that th ere is no correlation between the amount of carbon and δ13CDOC (Figure 4), further indicating that the carbon isotopic com- positions of DOC in speleothem ar e not affected by contamination." 4046 4878 W4395668730.pdf 4 33 separator 0.9823692 ¶ ¶ 4880 4886 W4395668730.pdf 4 34 caption 0.9966053 "Figure 3. The δ13CDOC results of different digestion durations. The green, blue, and pink dashed lines represent the average values of different durations respectively." 4886 5057 W4395668730.pdf 4 0 paratext 0.9903087 Curr. Oncol. 2024 ,31 1902 0 26 W4393480252.pdf 3 1 separator 0.99201894 ¶ 26 28 W4393480252.pdf 3 2 text 0.9962625 "in the B and CR groups was compared by the log-rank test ( p< 0.05). Secondly, uni- and multivariate Cox regression analyses of OS were performed in each group of patients. Only those variables that presented a p-value < 0.1 in the univariate analysis were included in the multivariate analysis." 28 330 W4393480252.pdf 3 3 separator 0.99618804 ¶ 330 332 W4393480252.pdf 3 4 title 0.9849273 3. Results 332 343 W4393480252.pdf 3 5 separator 0.9958103 ¶ 343 345 W4393480252.pdf 3 6 text 0.99155194 "A total of 99 patients (mean age, 61.18 years [SD = 11.45]; 41 women) were included. The CR group comprised 68 patients (68.7%), and the other 31 patients were in the B group. The clinical, radiological, and pathological features are shown in Table 1. Among the patients who underwent surgery with the intention of achieving CR, CR was achieved in 33 patients (48.5%). Resection in the remaining patients in the CR group was consid- ered subtotal." 345 803 W4393480252.pdf 3 7 separator 0.9967718 ¶ 803 805 W4393480252.pdf 3 8 title 0.9453371 Table 1. Clinical, radiological, and pathological features of the patients included in the study. 805 903 W4393480252.pdf 3 9 separator 0.97805166 ¶ 903 905 W4393480252.pdf 3 10 table 0.9958942 "VariableMean (SD) Count (%) Age 61.18 (SD = 11.45) Gender (female:male) 41:58 Karnofsky Performance Status (KPS) ≥70 91 (91.9%) Neurological deficit 74 (74.7%) Epileptic seizures 16 (16.2%) Headache 23 (23.2%) Brain hemisphereLeft 57 (57.6%) Right 40 (40.4% Bilateral 2 (2.0%) Contrast-enhancement typeRing 50 (51.0%) Heterogeneous 47 (48.0%) No enhancement 1 (1.0%) >2 lobes affected 27 (27.3%) Subventricular zone involvement 74 (74.7%) Corpus callosum involvement 39 (39.4%) Internal capsule < 1 cm 41 (41.4%) Contrast-enhancement volume (cc) 21.77 (SD = 15.22) Edema volumen (cc) 55.32 (SD = 34.78) Necrosis volumen (cc) 9.39 (SD = 9.92) Necrosis–tumor enhancement ratio (NTR) 0.41 (SD = 0.41) ASA1–2 76 (76.8%) 3–4 23 (23.2%) Risk of serious complication (%) 7.22 (SD = 3.44) Risk of any complication (%) 8.64 (SD = 3.41) Surgical intentionBiopsy 31 (31.3%) Complete 68 (68.7%) IDH mutation 1 (1.0%) Ki-67 > 20% 47 (52.2%) MGMT methylation 57 (58.2%)" 905 1921 W4393480252.pdf 3 0 bibliography 0.9948315 "M. Taboada, J. Brooke, M. Tofiloski, K. V oll, and M. Stede. 2011. Lexicon-based methods for sentiment analysis. Computational linguistics 37(2):267–307." 0 158 W2962974143.pdf 5 1 separator 0.99144614 ¶ 158 160 W2962974143.pdf 5 2 bibliography 0.9977943 "Amy Beth Warriner, Victor Kuperman, and Marc Brys- baert. 2013. Norms of valence, arousal, and dom- inance for 13,915 English lemmas. Behavior re- search methods 45(4):1191–1207." 160 345 W2962974143.pdf 5 3 separator 0.9847752 ¶ 345 347 W2962974143.pdf 5 4 bibliography 0.99622685 "T. Wilson, J. Wiebe, and P. Hoffmann. 2005. Rec- ognizing contextual polarity in phrase-level senti- ment analysis. In Proceedings of the conference on HLT/EMNLP 2005 . Vancouver, Canada.822" 347 544 W2962974143.pdf 5 0 paratext 0.98903096 469 Page 8 of 13 Eur. Phys. J. Plus (2022) 137:469 0 58 W4223993139.pdf 7 1 separator 0.9951911 ¶ 59 61 W4223993139.pdf 7 2 caption 0.86724025 "Fig. 8 EDX analyses corresponding to differentparticles within the yellow glazescontaining aSb, P" 61 161 W4223993139.pdf 7 3 table 0.55995256 b 161 162 W4223993139.pdf 7 4 caption 0.69735277 and Zn; 162 170 W4223993139.pdf 7 5 table 0.46431324 b 170 172 W4223993139.pdf 7 6 caption 0.4665087 S 172 173 W4223993139.pdf 7 7 table 0.4444942 b 173 174 W4223993139.pdf 7 8 caption 0.72568923 , 174 175 W4223993139.pdf 7 9 table 0.5708807 ¶ Pb 175 180 W4223993139.pdf 7 10 caption 0.49766368 and 180 184 W4223993139.pdf 7 11 table 0.60180104 Sn 184 187 W4223993139.pdf 7 12 caption 0.65144485 ; 187 188 W4223993139.pdf 7 13 table 0.6886615 cPb 188 192 W4223993139.pdf 7 14 caption 0.47245735 , 192 193 W4223993139.pdf 7 15 table 0.6967418 Sn 193 196 W4223993139.pdf 7 16 caption 0.54322594 , 196 197 W4223993139.pdf 7 17 table 0.6944541 Sb 197 200 W4223993139.pdf 7 18 caption 0.5187385 and 200 204 W4223993139.pdf 7 19 table 0.7010701 Zn 204 207 W4223993139.pdf 7 20 caption 0.4844072 ; 207 208 W4223993139.pdf 7 21 table 0.9532519 "¶ and dZn and Si 2000 4000 6000 8000 10000 12000(d) (c) (b) (a)ZnZn Si ZnSb Sn PbO C Sb PbPbSn SiAl Pb ZnSbPb Zn).u.a( stnuoc Energy (eV)" 208 376 W4223993139.pdf 7 22 separator 0.9859792 ¶ 376 378 W4223993139.pdf 7 23 caption 0.6923434 "Fig. 9 EDX analyses corresponding to orange andbrown glaze layers containingaS i ,P b ,S b ,A l ,M g ,N aa n dF e " 378 495 W4223993139.pdf 7 24 table 0.36661506 ¶ 495 496 W4223993139.pdf 7 25 caption 0.6788697 (orange); 496 506 W4223993139.pdf 7 26 table 0.48162064 bPb 506 510 W4223993139.pdf 7 27 caption 0.45263612 , S 510 513 W4223993139.pdf 7 28 table 0.5320622 b 513 514 W4223993139.pdf 7 29 caption 0.46934065 and 514 518 W4223993139.pdf 7 30 table 0.48900482 Fe ¶ 518 523 W4223993139.pdf 7 31 caption 0.39289913 ( 523 525 W4223993139.pdf 7 32 table 0.41059124 orange 525 531 W4223993139.pdf 7 33 caption 0.42426383 ); 531 533 W4223993139.pdf 7 34 table 0.5317055 "cMn and Fe (orange); dPb, Sb and Fe (brown); and eSi" 533 588 W4223993139.pdf 7 35 caption 0.36272675 , 588 589 W4223993139.pdf 7 36 table 0.52427125 ¶ Ca, Al, Mg, Na, Fe 589 610 W4223993139.pdf 7 37 caption 0.39254522 , 610 611 W4223993139.pdf 7 38 table 0.59052587 Mn 611 614 W4223993139.pdf 7 39 caption 0.4078212 and 614 618 W4223993139.pdf 7 40 table 0.56582594 Ni 618 621 W4223993139.pdf 7 41 caption 0.42092067 ( 621 622 W4223993139.pdf 7 42 table 0.45179224 red 622 625 W4223993139.pdf 7 43 caption 0.399997 p 625 627 W4223993139.pdf 7 44 table 0.94730324 "articles) 2000 4000 6000 8000 10000 12000Sn(e) (d) (c) (b) (a)PbSbPb Ni MnFe NaMgAlCa Fe Mn FeSbPb Sb Fe PbPbSi Al Mg).u.a(stnuoc Energy (eV)Na" 627 798 W4223993139.pdf 7 45 separator 0.98682654 ¶ 798 800 W4223993139.pdf 7 46 text 0.9996147 "A fragment with yellow color glaze was analyzed by SEM to study its yellow surface. The punctual chemical analyses showed the presence of particles composed of Sb, Pb and Zn (Fig. 8a). Other particles were composed of Sb and Pb with high contents of Sn (Fig. 8b) or Pb, Sn, Sb and Zn (Fig. 8c). In addition, the particles mainly consisted of Zn accompanied by Si (Fig. 8d). These data could indicate the presence of different compounds based on Naples yellow but with inclusions in their pyrochlore structure ofZn, Sn or both cations simultaneously." 800 1356 W4223993139.pdf 7 47 separator 0.99639726 ¶ 1356 1358 W4223993139.pdf 7 48 title 0.98524094 Orange and brown colors 1358 1382 W4223993139.pdf 7 49 separator 0.9959245 ¶ 1382 1384 W4223993139.pdf 7 50 text 0.9997175 "EDX analyses of the orange color showed the presence of Si, Pb, Sb, Al, Mg, Na and Fe. Sn was also present (Fig. 9a). Punctual chemical analyses showed the presence of Pb, Sb and Fe (Fig. 9b). These analyses also showed that the particles were mainly composed of Mn and Fe (Fig. 9c)." 1384 1672 W4223993139.pdf 7 51 separator 0.9028709 ¶ 1672 1674 W4223993139.pdf 7 52 text 0.9996749 "Regarding the brown color, the EDX analyses showed the presence of Pb, Sb and Fe (Fig. 9d). Punctual analyses of small particles of reddish color (Fig. 4h) showed that they were constituted by Si, Ca, Al, Mg, Na, Fe, Mn and Ni (Fig. 9e); the last three elements are responsible for the reddish color. Important iron oxide quantities (ca. 2.7 and 3.0% for orange and brown, respectively) havebeen found in these colors (Table 1)." 1674 2107 W4223993139.pdf 7 53 separator 0.9707954 ¶ 2107 2109 W4223993139.pdf 7 54 text 0.99582237 "As described in the results provided by EDX, iron was also present in variable amounts as a chromophore of the glassy matrix. This element may be included in the structure of Pb 2Sb2O7and form an Fe-modified pigment during the ceramic firing process [27]. The incorporation of Fe inside the pigment lattice was largely described by Cartechini et al. [ 28]. The punctual chemical analyses carried out in our study (Fig. 9d) suggest the possibility of the formation of the abovementioned phase in the orange and brown glazes. The light Naples yellow darkens with exposure to iron. The punctual chemical analyses also showed the presence ofFe-based compounds are not associated with Pb and Sb but with Mn (Fig. 9e). In other ceramics from the Alcazar [3], Mn and Fe were detected in the darkest color areas." 2109 2924 W4223993139.pdf 7 55 separator 0.99177814 ¶ 2924 2926 W4223993139.pdf 7 56 paratext 0.9682264 123 2926 2930 W4223993139.pdf 7 0 paratext 0.9378024 "¶ ¶ www.ioles. com. br/boca ¶" 1 37 W4387228821.pdf 16 1 separator 0.7921802 ¶ ¶ 39 45 W4387228821.pdf 16 2 title 0.9025063 BOLETIM DE CONJUN TURA (BOCA) ano V, vol. 15, n. 45, Boa Vista, 2023 45 115 W4387228821.pdf 16 3 separator 0.9933955 ¶ 116 118 W4387228821.pdf 16 4 text 0.9367298 "764 Governo Federal a terceirizar algumas funções para o setor p rivado, como a segura nça nos abrigos, que já está sendo feita com custos crescentes." 119 273 W4387228821.pdf 16 5 separator 0.97138715 ¶ 275 277 W4387228821.pdf 16 6 text 0.99874836 "Em contraste, o artigo ""Migrações Internacionais Contemporâneas e a Crise de Refugiados na Região Noroeste do Brasil: O Caso do Acolhimento Venezuelano pelo Estado de Rora ima (2018 - 2019),"" de Érica Silva e Fernando Rod rigues (2020), afirma que o fluxo migratório venezuelano foi classificado como um problema de segurança devido ao seu comando por um general do Exército e define a militarização da Operação." 277 701 W4387228821.pdf 16 7 separator 0.94473004 ¶ 703 705 W4387228821.pdf 16 8 text 0.9995074 "No e ntanto, a Oper ação Acolhida é um es forço interministerial coo rdenado pela Casa Civil. A Força -Tarefa logística e humanitária, por outro lado, tem um General de Divisão como coordenador operacional. É evidente que os autores confundiram ambas as figuras e n ão compreender am o complexo arranjo institucional da operação ." 705 1046 W4387228821.pdf 16 9 separator 0.9818832 ¶ 1047 1049 W4387228821.pdf 16 10 text 0.9994945 "Silva e Rodrigues (2020) também afirmam que o processo de triagem funciona como um meio de restringir o sujeito migrante. Além disso, argumentam que o processo, sendo controlado pelo estado e militarizado, e stá ideologicamente i mbuído de controle excessi vo de segurança, comum entre as forças de repressão do estado, diante do inimigo percebido na travessia dos venezuelanos." 1049 1437 W4387228821.pdf 16 11 separator 0.97209656 ¶ 1439 1441 W4387228821.pdf 16 12 text 0.9992352 "Praticamente não existem restrições para indivíduos que passam pelo proce sso de triagem . Além disso, como me ncionado anteriormente, o Posto de Triagem (PTRIG) em Pacaraima é um local que abrange várias agências intergovernamentais, organizações não governamentais e entidades federais pertencentes à Operação Acolhida e, no Brasi l, a autoridad e migratória é a Polí cia Federal e não as Força s Armadas." 1441 1861 W4387228821.pdf 16 13 separator 0.95424557 ¶ 1863 1865 W4387228821.pdf 16 14 text 0.99922246 "Além disso, desde 2019, o governo brasileiro simplificou o processo de reconhecimento do status de refugiado dos imigrantes venezuelanos, caracterizando -os como refugiados devido à ""gr ave e generali zada violação dos dir eitos humanos"" na Venezuel a e concedendo reconhecimento prima facie aos nacionais venezuelanos." 1865 2194 W4387228821.pdf 16 15 separator 0.97545624 ¶ 2196 2198 W4387228821.pdf 16 16 text 0.99937624 "Silva e Rodrigues (2020) também afirmam que as Forças Armadas Brasileiras acabam assumindo um papel que pertence a outros ato res estatais e argumentam que esse papel assumido em tarefas subsidiárias desvia do papel das Forças Armadas conforme delineado na Constituição Federal de 1988, que é a defesa da nação, a garantia dos poderes constitucionais, a manutenção da ordem pública e a participaç ão em operações inter nacionais." 2198 2641 W4387228821.pdf 16 17 separator 0.9806402 ¶ 2643 2645 W4387228821.pdf 16 18 text 0.9994548 "Nesse sentido, os autores estão corretos em suas críticas. Primeiramente, eles estabelecem que as Forças Armadas desempenham um papel que deveria ser realizado por outros órgãos do governo. A questão é que, dev ido à complexi dade logística e à di stância dos principais cen tros urbanos do país, a" 2645 2950 W4387228821.pdf 16 0 text 0.96081316 "consumers and traders. Focus Group Discussions (FGD) held with women group of 15 members who were randomly selected to represent camel milk pro- ducers, herders, milk traders, and consumers at Isiolo and Eastleigh, Nairobi. This was done to identify handling practices along the value chain." 0 301 W2536399810.pdf 2 1 separator 0.99638397 ¶ 301 303 W2536399810.pdf 2 2 title 0.9872144 Milk sampling 303 317 W2536399810.pdf 2 3 separator 0.9932328 ¶ 317 319 W2536399810.pdf 2 4 text 0.9995925 "Samples of raw camel milk and suusa were collected in triplicates at each representative point of the value chain for microbiological analysis. At production, pooled milk samples from the herds. Milk samples were collected from each container at the herd level and later pooled to make a representative sample of 20. At bulking centres, a total of 12 random samples were collected from each cooling hub. A total of 7 unintended suusa samples were collected at the time of the study while a total of 10 intended suusa were collected. Intended suusa was col- lected from pastoral women who were requested to pre- pare it since the commodity is rare. A total of 10 suusa samples were collected from Eastleigh, Nairobi market from 10 traders. Pooled suusa sample was made by pool- ing milk from as many containers as each woman trader had to obtain a representative sample. At each sampling point, 50 ml of milk sample was taken and transferred into sterile screw-capped sampling bottles, securely capped, clearly labelled and immediately transported to the laboratory for analysis under ice (4 °C). A total of 59 samples were obtained for titratable acidity and micro- bial analysis." 319 1542 W2536399810.pdf 2 5 separator 0.99725807 ¶ 1542 1544 W2536399810.pdf 2 6 title 0.9868799 Sample analysis 1544 1560 W2536399810.pdf 2 7 separator 0.9948752 ¶ 1560 1562 W2536399810.pdf 2 8 text 0.9995753 "The raw camel milk and suusa samples analysis was done at Egerton University, Food microbiology labora- tory. Serial dilution of up to 10−6was done using pep- tone water and 1 ml of homogenate of sample was aseptically transferred into a sterile petri dish. Total Viable Counts (TVC) was enumerated on Plate Count Agar (PCA) (Oxoid, UK) using pour plating method and the plates incubated at 37 °C for 48 hours. The Coli- forms counts (CC) were enumerated on Violet Red Bile Agar (VRBA) (Oxoid, UK) using pour plating technique and plates incubated at 37 °C for 24 hours(AOAC, 1995). The Spore Counts (SC) were enumerated by heat treating milk samples in a water bath at 80 °C for 10 - minutes and 1 ml of appropriate dilution pour plated on (PCA) (Oxoid, UK) and the plates incubated at 37 °C for 24 hours (AOAC, 1995). While the yeast and mould were determined on Potato Dextrose Agar (PDA) (Oxoid, UK) by spread plating technique and the plates incubated at 25 °C for 5 days (AOAC, 1995)." 1562 2589 W2536399810.pdf 2 9 separator 0.9729481 ¶ 2589 2591 W2536399810.pdf 2 10 text 0.9997086 "Discrete colonies grown on plates after incuation were selected randomly and purified by repeated plating on the same agar according to Lore et al. (2005). Thecolonies were then subjected to morphological (cell shape, motility, cell grouping and endospores), biochem- ical (catalase, oxidase, carbohydrate utilization, indole, and Methyl red-Vosges-Proskauer) and physiological tests and identified to genus level (AOAC, 1995)." 2591 3031 W2536399810.pdf 2 11 separator 0.98191637 ¶ 3031 3033 W2536399810.pdf 2 12 text 0.99953216 "Developed acidity in the samples was determined according to the method described by the International Dairy Federation (I.D.F.) (1990). 9 ml of the milk sam- ples were measured into the conical flasks, and 1 ml 0.5 % alcoholic phenolphthalein indicator added then titrating with 0.1 N sodium hydroxide (NaOH) until a faint pink colour appears. The results were then expressed as % lactic acid where 1/10 ml NaOH is equal to 0.09 % w/v lactic acid." 3033 3498 W2536399810.pdf 2 13 separator 0.99694073 ¶ 3498 3500 W2536399810.pdf 2 14 title 0.9928034 Statistical analysis of data 3500 3529 W2536399810.pdf 2 15 separator 0.99405754 ¶ 3529 3531 W2536399810.pdf 2 16 text 0.99962884 "The microbial counts for the total viable count (TVC), coliform count (CC), spore count (SC), yeast and mould count (YM) were transformed to base-10 logarithm of colony forming units (cfus) per millilitre (ml) of the milk samples (log 10cfu/ml). The transformed data was tested for normality using PROC NPAR1WAY procedure of Komolgorov –Smirnoff's test and also tested for homo- geneity of variances using Levene ’s test before assump- tion of analysis of variance (ANOVA) was done using the General Linear Model (GLM) procedure of SAS ver- sion 9.1 (SAS Institute, Inc., Cary, NC). The independent variable was the milk quality and value chain points (production, bulking, processing and marketing). The significance of the means was determined using Tukey ’s Honestly Significance Difference (HSD) test at P< 0.05." 3531 4376 W2536399810.pdf 2 17 separator 0.9966115 ¶ 4376 4378 W2536399810.pdf 2 18 title 0.9830366 Results 4378 4386 W2536399810.pdf 2 19 separator 0.9916338 ¶ 4386 4388 W2536399810.pdf 2 20 title 0.98913234 Mapping the suusa value chain 4388 4418 W2536399810.pdf 2 21 separator 0.9910271 ¶ 4418 4420 W2536399810.pdf 2 22 text 0.9995361 "The value chain for s uusa mapped from surveys and FGD is represented in Fig. 1, revealing the handling practices along the value chain. Camels are milked at “boma ”(simi- lar to a kraal) by herders. Fresh milk is bought by women groups or individuals to make suusa or sell in open air market. Soured milk is downgraded and sold as un- intended suusa . Fresh camel milk and suusa is consumed by both pastoralists and non-pastoralists." 4420 4869 W2536399810.pdf 2 23 separator 0.97014886 ¶ 4869 4871 W2536399810.pdf 2 24 text 0.9946651 "The common camel milk handling practices that influ- ence the contamination levels in milk is shown in Table 1. It was found that all herders neither wash their hands nor wash the camel udder before milking and all camel milk handling containers were plastic. After milk- ing and bulking at the herd level, all milk was found to be transported by the either motorbikes when the herd was near Isiolo town or trucks when the herds were far from the town e.g. from Kulamawe which was about 100 KM form Isiolo town. Isiolo town is the main collection center for raw camel milk where there are cooling facilities for the milk. At Isiolo, milk" 4871 5531 W2536399810.pdf 2 25 paratext 0.96951896 Mwangi et al. International Journal of Food Contamination (2016) 3:18 Page 3 of 9 5531 5613 W2536399810.pdf 2 0 paratext 0.9866632 http://www.diva-portal.org 0 26 W2193999258.pdf 0 1 separator 0.9827971 ¶ 26 28 W2193999258.pdf 0 2 paratext 0.669661 This is the published version of a paper published in Journal of Yoga & Physical therapy. 28 118 W2193999258.pdf 0 3 separator 0.9889902 ¶ 118 120 W2193999258.pdf 0 4 title 0.40527284 Citation 120 129 W2193999258.pdf 0 5 text 0.45115355 for the original 129 146 W2193999258.pdf 0 6 title 0.46947432 published 146 156 W2193999258.pdf 0 7 text 0.48183355 paper (version of record): 156 183 W2193999258.pdf 0 8 separator 0.99038136 ¶ 183 185 W2193999258.pdf 0 9 bibliography 0.9738979 Kjellgren, A., Andersson, M. (2015) 185 221 W2193999258.pdf 0 10 separator 0.8148112 ¶ 221 223 W2193999258.pdf 0 11 bibliography 0.9106739 Relaxation and Wellness through Yoga Practice. 223 270 W2193999258.pdf 0 12 separator 0.77231574 ¶ 270 272 W2193999258.pdf 0 13 bibliography 0.7403276 Journal of Yoga & Physical therapy, 5(4) 272 313 W2193999258.pdf 0 14 separator 0.62829113 ¶ 313 315 W2193999258.pdf 0 15 paratext 0.7815639 https://doi.org/10.4172/2157-7595.1000219 315 357 W2193999258.pdf 0 16 separator 0.9875692 ¶ 357 359 W2193999258.pdf 0 17 text 0.4011596 Access to the published version 359 391 W2193999258.pdf 0 18 paratext 0.36954993 may 391 395 W2193999258.pdf 0 19 text 0.47381756 require subscription. 395 417 W2193999258.pdf 0 20 separator 0.5910029 ¶ 417 419 W2193999258.pdf 0 21 text 0.54410565 N.B. When citing this work, cite the original published paper. 419 482 W2193999258.pdf 0 22 separator 0.9922641 ¶ 482 484 W2193999258.pdf 0 23 paratext 0.9214568 "Permanent link to this version: http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-38847" 484 573 W2193999258.pdf 0 0 paratext 0.9706663 CORRECTION OPEN 0 15 W4385064589.pdf 0 1 separator 0.90685916 ¶ 15 17 W4385064589.pdf 0 2 title 0.95606333 Correction: Supporting Weight Management during COVID-19 17 74 W4385064589.pdf 0 3 separator 0.48630995 ¶ 74 76 W4385064589.pdf 0 4 title 0.72839355 (SWiM-C): twelve-month follow-up of a randomised controlled 76 137 W4385064589.pdf 0 5 text 0.43351504 ¶ 137 138 W4385064589.pdf 0 6 title 0.6457515 trial of a 138 149 W4385064589.pdf 0 7 text 0.461546 web 149 153 W4385064589.pdf 0 8 title 0.61278343 -based, ACT-based, guided self-help intervention 153 201 W4385064589.pdf 0 9 separator 0.99392366 ¶ 201 203 W4385064589.pdf 0 10 bibliography 0.9724414 "Julia Mueller , Rebecca Richards, Rebecca A. Jones , Fiona Whittle, Jennifer Woolston, Marie Stubbings , Stephen J. Sharp , Simon J. Grif fin, Jennifer Bostock, Carly A. Hughes, Andrew J. Hill , Clare E. Boothby and Amy L. Ahern" 203 433 W4385064589.pdf 0 11 separator 0.9554632 ¶ 433 435 W4385064589.pdf 0 12 paratext 0.93638873 "© The Author(s) 2023 International Journal of Obesity (2023) 47:882; https://doi.org/10.1038/s41366-023-01330-4 Correction to: International Journal of Obesity https://doi.org/ 10.1038/s41366-022-01232-x , published online 11 November 2022" 435 681 W4385064589.pdf 0 13 separator 0.9915449 ¶ 681 683 W4385064589.pdf 0 14 text 0.99731576 "The authors have discovered an error in the way the data for three of the secondary outcomes were processed." 683 794 W4385064589.pdf 0 15 separator 0.5596365 ¶ 794 796 W4385064589.pdf 0 16 text 0.99751693 "The error pertains to the three subscales of the Three Factor Eating Questionnaire. The TFEQ-R21 consists of 21 items, and responsesto each of the items were given a score between 1 and 4 and item scores were summated into scale scores for cognitive restraint, uncontrolled eating, and emotional eating. The raw scale scoreswere then transformed to a 0 –100 scale using the formula: ((raw score−lowest possible raw score)/possible raw score range) * 100" 796 1258 W4385064589.pdf 0 17 separator 0.54730684 ¶ 1258 1260 W4385064589.pdf 0 18 text 0.77886266 (see: 1260 1266 W4385064589.pdf 0 19 bibliography 0.68264216 de Lau 1266 1273 W4385064589.pdf 0 20 text 0.58158994 zon 1273 1276 W4385064589.pdf 0 21 bibliography 0.76897043 et al. The Three-Factor Eating Qu 1276 1310 W4385064589.pdf 0 22 text 0.5114578 estionnaire 1310 1321 W4385064589.pdf 0 23 bibliography 0.62581486 -R18 isable 1321 1332 W4385064589.pdf 0 24 text 0.72216207 to distinguish among different eating patterns in 1332 1382 W4385064589.pdf 0 25 bibliography 0.80808675 1382 1383 W4385064589.pdf 0 26 text 0.69799674 a general 1383 1392 W4385064589.pdf 0 27 bibliography 0.80864084 "population. J Nutr. 2004;134:2372 –80.https://doi.org/10.1093/jn/ 134.9.2372 . PMID: 153337" 1392 1485 W4385064589.pdf 0 28 text 0.7313764 31). 1485 1489 W4385064589.pdf 0 29 separator 0.98492277 ¶ 1489 1491 W4385064589.pdf 0 30 text 0.9988146 "The possible raw score range is the range of the scale (1 –4, so 3) multiplied by the number of items. For example, if a participant completed the 6 items on the Restraint Subscale, the possible rawscore range is 3 * 6 =18. Unfortunately, the authors used 4 instead of 3 for the range of the scale, which means that instead oftransforming the scores to a 0 –100 scale, they transformed the scores to a 0 –75 scale. This has now been corrected in the tables below." 1491 1965 W4385064589.pdf 0 31 separator 0.8681165 ¶ 1965 1967 W4385064589.pdf 0 32 text 0.9985955 "This does not affect the overall results and the conclusions remain the same, but, using the corrected scoring method, the authors obtained slightly different numbers for three of their secondary outcomes. The original article has been corrected." 1967 2220 W4385064589.pdf 0 33 separator 0.9722063 ¶ 2220 2222 W4385064589.pdf 0 34 paratext 0.93978655 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you giveappropriate credit to the original author(s) and the source, provide a link to the CreativeCommons license, and indicate if changes were made. The images or other third party material in this article are included in the article ’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in thearticle ’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directlyfrom the copyright holder. To view a copy of this license, visit http:// creativecommons.org/licenses/by/4.0/ ." 2222 3085 W4385064589.pdf 0 35 separator 0.904596 ¶ 3085 3087 W4385064589.pdf 0 36 paratext 0.9485223 "© The Author(s) 2023 Published online: 21 July 2023www.nature.com/ijo International Journal of Obesity1234567890();,:" 3087 3207 W4385064589.pdf 0 0 paratext 0.94398946 Томакова Р. А., Иванов Д. В., Корсунский Н. А. Интеллектуальная система обес печения миграции ... 51 0 110 W4391275741.pdf 20 1 separator 0.933431 ¶ 111 113 W4391275741.pdf 20 2 paratext 0.7473811 Proceedings of the Southwest State University. Seri es: Control, Computer Engineering, 113 200 W4391275741.pdf 20 3 separator 0.40635598 202 203 W4391275741.pdf 20 4 paratext 0.73967046 ¶ Information Science. Medical Instruments Engineering . 2023; 13(3): 31 –51 203 279 W4391275741.pdf 20 5 bibliography 0.9853318 "20. Doolan D. Migraciya dannyh: prakticheskoe rukovodstvo po effektivnomu perenosu dannyh [Data Migration: A Practical Guide to Effective Data Migration]. Wimbledon, Lon- don, BCS Learning & Development Ltd Publ., 2020, pp. 301‒312." 279 517 W4391275741.pdf 20 6 separator 0.9229064 ¶ 519 521 W4391275741.pdf 20 7 paratext 0.91584134 _________________________ 521 547 W4391275741.pdf 20 8 separator 0.9948604 ¶ 548 550 W4391275741.pdf 20 9 title 0.9707763 Информация об авторах / Information about the Authors 550 604 W4391275741.pdf 20 10 separator 0.994079 ¶ 606 608 W4391275741.pdf 20 11 contact 0.98794335 "Томакова Римма Александровна, доктор технических наук, профессор, профессор кафедры программной инженерии, Юго -Западный государственный университет, г. Курск, Российская Федерация , e-mail: rtomakova@mail.ru , Researcher ID: O-6164-2015, ORCID: 0000-0003-152-4714 Rimma A. Tomakova, Dr. of Sci. (Engineering), Professor, Professor of the Department of Software Engineering, Southwest State University, Kursk, Russian Federation, e-mail: rtomakova@mail.ru , Researcher ID: O-6164-2015, ORCID: 0000-0003-152-4714" 608 1166 W4391275741.pdf 20 12 separator 0.97728646 ¶ 1167 1169 W4391275741.pdf 20 13 contact 0.98971194 "Иванов Дмитрий Вадимович, магистрант, Юго -Западный государственный университет , г. Курск, Российская Федерация, e-mail: asmadisel@yandex.ru , ORCID: 0009-0004-5581-1641 Dmitry I. Vadimovich, Undergraduate, Southwest State University, Kursk, Russian Federation, e-mail: asmadisel@yandex.ru , ORCID: 0009-0004-5581-1641" 1169 1519 W4391275741.pdf 20 14 separator 0.94539416 ¶ 1520 1522 W4391275741.pdf 20 15 contact 0.9869016 "Корсунский Никита Александрович, аспирант, Юго -Западный государственный университет, г. Курск, Российская Федерация, e-mail: cor.nick2013@yandex.ru , ORCID: 0009-0005-4606-5517 Nikita A. Korsunsky, Post-Graduate Student, Southwest State University, Kursk, Russian Federation, e-mail: cor.nick2013@yandex.ru , ORCID: 0009-0005-4606-5517" 1522 1888 W4391275741.pdf 20 16 separator 0.9926638 ¶ ¶ 1889 1896 W4391275741.pdf 20 0 paratext 0.8983341 18/05/2024 11:27Ranking 0 23 W2107387902.pdf 0 1 bibliography 0.5591871 paths in stoch 23 38 W2107387902.pdf 0 2 title 0.48716295 astic 38 43 W2107387902.pdf 0 3 bibliography 0.92509234 "time-dependent networks / Lars Relund, Nielsen; Kim Allan, Andersen; Pretolani, Daniele. - In: EUROPEAN JOURNAL OF OPERATIONAL RESEARCH. - ISSN 0377-2217. - STAMPA. -" 43 212 W2107387902.pdf 0 4 separator 0.9034928 ¶ 212 214 W2107387902.pdf 0 5 paratext 0.9178192 236:3(2014), pp. 903-914. [10.1016/j.ejor.2013.10.022] 214 269 W2107387902.pdf 0 6 separator 0.9944103 ¶ 269 271 W2107387902.pdf 0 7 title 0.85289776 Terms of use 271 284 W2107387902.pdf 0 8 paratext 0.5083859 : 284 285 W2107387902.pdf 0 9 separator 0.91480625 ¶ 285 287 W2107387902.pdf 0 10 paratext 0.55189735 "The terms and conditions for the reuse of this version of the manuscript are specified in the publishing policy. For all terms of use and more information see the publisher's website." 287 473 W2107387902.pdf 0 11 separator 0.9858185 ¶ 473 475 W2107387902.pdf 0 12 paratext 0.78643715 (Article begins on next page)This is a pre print version of the following article: 475 558 W2107387902.pdf 0 0 paratext 0.8530966 Imbernón Cuadrado et al. ARTIE ¶ 0 32 W2483985165.pdf 2 1 title 0.51935995 in 32 35 W2483985165.pdf 2 2 paratext 0.49313423 education 35 44 W2483985165.pdf 2 3 title 0.53660715 ,duetothestrongrelationshipbetween 44 78 W2483985165.pdf 2 4 paratext 0.48741618 emo 78 81 W2483985165.pdf 2 5 title 0.49859804 tio 81 84 W2483985165.pdf 2 6 paratext 0.5341866 84 85 W2483985165.pdf 2 7 title 0.50187796 ns 85 87 W2483985165.pdf 2 8 paratext 0.55322707 ¶ 87 89 W2483985165.pdf 2 9 title 0.554738 andmentalprocessesofcognitivenature 89 125 W2483985165.pdf 2 10 paratext 0.5128746 . 125 126 W2483985165.pdf 2 11 separator 0.98987365 ¶ 126 128 W2483985165.pdf 2 12 text 0.97847694 "In this section, we present the current state in the research areas of interest for this paper, putting the work in context and justifying the technological choices taken to carry it o ut." 128 321 W2483985165.pdf 2 13 separator 0.80375636 ¶ 321 323 W2483985165.pdf 2 14 text 0.997678 "Such areas are: affective robotics in education, requirement s engineering for the development of affective educational software, recognition of emotional states from keyboard an d mouse interactions, and markup languages for the specificati on ofrobotsandvirtualagents." 323 599 W2483985165.pdf 2 15 separator 0.9964069 ¶ 599 601 W2483985165.pdf 2 16 title 0.99289024 2.1.1. Affective Robotics in Education 601 640 W2483985165.pdf 2 17 separator 0.99333143 ¶ 640 642 W2483985165.pdf 2 18 text 0.997525 "Human Robot Interaction (HRI), and, in particular, Socially AssitiveRobotics(SAR)arekeystonesinactualroboticsrese arch. In this context, developing virtual agents as a teaching reso urce, given their potential to simulate real social interaction, i s today an open question. However, as set forth in Saerbeck et al. (2010) the appearance of the educational agent has a significant impact on user behavior. It has been shown that having the perception ofapartnertointeractwithcanbeimprovedbyusingaphysical robot.Nevertheless,itshouldbenotedthattheacceptanceo fthe robot by teachers is vital to ensuring its benefits as an educa tion assistancetool( FridinandBelokopytov,2013 )." 642 1337 W2483985165.pdf 2 19 separator 0.9745462 ¶ 1337 1339 W2483985165.pdf 2 20 text 0.9994991 "Educational robots have positive influence on the learning processes, helping students to get better test scores ( Catlin and Robertson, 2012 ) and increasing more than books or other audio-visual resources their interest ( Mubin et al., 2013 )." 1339 1590 W2483985165.pdf 2 21 separator 0.97170067 ¶ 1590 1592 W2483985165.pdf 2 22 text 0.9996865 "Within education, robotics initially adopted the perspective of constructivism, in which students learn to solve problems by building a physical artifact. Later the notion of social constructivismproposedbyVygotskywasintroducedandisnow theperspectiveadoptedbymosteducationmethodologiesbased onrobottutors( Mubinetal.,2013 )." 1592 1927 W2483985165.pdf 2 23 separator 0.96883416 ¶ 1927 1929 W2483985165.pdf 2 24 text 0.999686 "Inprimaryeducationalargenumberofstudieswithdifferent robots have been carried out. Two different approaches can be considered:onewheretherobottutorplaystheroleofateach er, teachinglessonstothestudent,asin Kerenetal.(2012) andother where the role of the robot is to receive care, as in Tanaka and Matsuzoe(2012) ." 1929 2250 W2483985165.pdf 2 25 separator 0.9043814 ¶ 2250 2252 W2483985165.pdf 2 26 text 0.99145925 "Notably,inallthestudiesanalyzed,thepresenceofaroboti n aclassroomsignificantlyimprovesthelearningcurveofstud ents. However,despitetheinitialincreaseinmotivationofthest udents due to the presence of the robots, they gradually lose interest in them ( Jimenez et al., 2015 ). Due to these findings studies on affectiveeducationwerecarriedoutinthefieldofrobotics." 2252 2618 W2483985165.pdf 2 27 separator 0.95846045 ¶ 2618 2620 W2483985165.pdf 2 28 text 0.99962646 "Therefore, socially interactive robots should ideally hav e a number of features such as the ability to express or perceive emotions, to communicate via high-level dialogue, to learn a nd recognize patterns of other agents, to establish and maintai n social relationships, to use natural signs, to display a distin ctive personalityandtolearnsocialskills( Fongetal.,2002 )." 2620 3004 W2483985165.pdf 2 29 separator 0.9817066 ¶ 3004 3006 W2483985165.pdf 2 30 text 0.9996547 "As mentioned previously, SAR have great potential for developing efficient educational tools ( Keren et al., 2012 ). In recent years there has been an increase in the development of socially interactive robots with the ability to interpret so cial characteristics ( Vouloutsi et al., 2014 ) which enable them tointeract naturally with humans ( Salam and Chetouani, 2015 ). In Fong et al. (2002) , an extensive study of the state of the art on socially-interactive robots at that time is presented concl uding that, to give credibility to the interaction between a robot a nd a person, the robot has to incorporate artificial emotions and recognizehumanemotions;theauthorsdrawattentiontothe role ofspeech,facialexpressionsandbodylanguageashighlyeffect ive methods of communicating emotions ( Breazeal and Aryananda, 2002).Robotstrainedtoidentifystudentemotionsthroughfacia l and gesture recognition can provide effective assistance to the teacher(VeenaVijayan,2014 )." 3006 3996 W2483985165.pdf 2 31 separator 0.98543125 ¶ 3996 3998 W2483985165.pdf 2 32 text 0.99965733 "In recent times, social and assistant robots have been used in many educational projects involving preschool children, o ne example being the use of NAO ( Softbank Robotics, 2016 ) in Kindergarten Assistive Robotics (KAR) ( Keren et al., 2012 ). The use of robots in special education has also been shown to be effective,particularlyineducationforchildrenwithASD( Robins etal.,2004;Ismailetal.,2012 )." 3998 4411 W2483985165.pdf 2 33 separator 0.9972551 ¶ 4411 4413 W2483985165.pdf 2 34 title 0.9931499 2.1.1.1.Affectiverobotsandrecommendersystems 4413 4457 W2483985165.pdf 2 35 separator 0.99562246 ¶ 4457 4459 W2483985165.pdf 2 36 text 0.9996924 "Theprocessofacquiringknowledgeisakeycomponentforsocia l robots, enabling them to improve their actions in a dynamic human environment. For this reason, one of the approaches to the implementation of knowledge systems in robots is to imita te the human cognitive processes involved in the interaction wi th differentenvironments( Kooetal.,2011 ).Tooperateasagenuine tutor and make appropriate educational interventions, a robot must know the learning subject, the competencies of students , and the specific circumstances which create the need for each particular learning intervention. A possible means to provide a robot with this knowledge is to establish a communication between the robot and an affective educational recommender systemwithwhichthestudentsinteract." 4459 5249 W2483985165.pdf 2 37 separator 0.9396311 ¶ 5249 5251 W2483985165.pdf 2 38 text 0.9996449 "Inthecontextofhealthcareprogresshasbeenmaderegarding the communication between robots and recommender systems, seeHammer et al. (2015) andTang et al. (2015) . Robots connectedtorecommendersystemshavealsobeendevelopedin thecontextofbusinessprovidingotherservicesasshownin Koo etal.(2011) andKameietal.(2011) ." 5251 5570 W2483985165.pdf 2 39 separator 0.8397511 ¶ 5570 5572 W2483985165.pdf 2 40 text 0.99960375 "However, in the context of education to date we have not found any reference of robots which operate jointly with an educationalrecommendersystem." 5572 5723 W2483985165.pdf 2 41 separator 0.7162355 ¶ 5723 5725 W2483985165.pdf 2 42 text 0.9996085 "Therearethereforeenoughstudiessupportingthehypothesis that the use of robots, and particularly affective robots, in education can improve learning processes, as concluded in Saerbecketal.(2010) ,Capponietal.(2010) ,Jimenezetal.(2015) , andKeren et al. (2012) . The greatest benefits of using robots as an educational tool are obtained in infant and primary school children. The availability of non-intrusive and low cost meth ods and tools to facilitate social interaction between children and robots is crucial to the use of affective robot tutors becoming widespread in infant and primary education. Also noteworthy is thelackofresearchwithregardtotheintegrationofeducat ional recommendersystemsandrobots." 5725 6452 W2483985165.pdf 2 43 separator 0.6081697 ¶ 6452 6454 W2483985165.pdf 2 44 text 0.9950612 "Under the above considerations, we aim to facilitate the implementation of affective robot tutors which operate jointly with an educational recommender system for elementary ¶" 6454 6633 W2483985165.pdf 2 45 paratext 0.9838954 Frontiers in Computational Neuroscience | www.frontiersi n.org 3 August 2016 | Volume 10 | Article 77 6633 6735 W2483985165.pdf 2 0 separator 0.9650022 ¶ ¶ 1 6 W2570674397.pdf 5 1 math 0.85411525 "c) /g302 = 600 ¶ a) /g302 = 900 b) /g302 = 750" 6 125 W2570674397.pdf 5 2 separator 0.99339855 ¶ 126 128 W2570674397.pdf 5 3 caption 0.99557 Fig. 7. Values of impact forces for nozzle diameter D=2 mm for different values of impact angle /g302. 128 232 W2570674397.pdf 5 4 separator 0.9958595 ¶ 233 235 W2570674397.pdf 5 5 title 0.9933809 3.3 Determining the Influence of the process parameters 235 291 W2570674397.pdf 5 6 separator 0.9957224 ¶ 292 294 W2570674397.pdf 5 7 text 0.9967614 "Using the Full factorial method has conducted an analysis of the variance to determine the contribution of each parameter and their interactions on the impact force. Table 2 presents the analysis of the variance, using Minitab 17." 294 531 W2570674397.pdf 5 8 separator 0.9961126 ¶ 532 534 W2570674397.pdf 5 9 title 0.8538786 Table 2. Analysis of Variance (Minitab 17). 534 579 W2570674397.pdf 5 10 separator 0.8812593 ¶ 580 582 W2570674397.pdf 5 11 table 0.99667794 "Source DF (degree of freedom) Seq. SS (sum of square) Contribution Model 103 163,747 99.87% Linear 16 153,677 93.73% Diameter 2 117,239 71.50% Pressure 5 29,641 18.08% Distance 7 410 0.25% Angle 2 6,387 3.90% 2-Way Interactions 87 10,070 6.14% Diameter*Pressure 10 7,626 4.65% Diameter*Distance 14 333 0.20% Diameter*Angle 4 1,636 1.00% Pressure*Distance 35 55 0.03% Pressure*Angle 10 414 0.25% Distance*Angle 14 6 0.00% Error 328 217 0.13% Total 431 163,965 100.00%" 582 1102 W2570674397.pdf 5 12 separator 0.9073639 ¶ ¶ 1103 1111 W2570674397.pdf 5 13 paratext 0.97412187 "DOI: 10.1051/ , (2017) 79407005 94 matecconf/201 MATEC Web of Conferences CoSME'1607005" 1113 1204 W2570674397.pdf 5 14 separator 0.59369 1205 1206 W2570674397.pdf 5 15 paratext 0.766557 ¶ 6 1206 1209 W2570674397.pdf 5 0 text 0.993879 "ability of SCL and CS in order to improve their electro- spinnability while reducing the PEO content. SCL, CS and PEO are blended in aqueous solutions of acetic acid and subsequently electrospun." 0 201 W1964811855.pdf 2 1 separator 0.9964254 ¶ 201 203 W1964811855.pdf 2 2 title 0.9886903 Experimental 203 216 W1964811855.pdf 2 3 separator 0.9771491 ¶ 216 218 W1964811855.pdf 2 4 text 0.99899334 "MaterialsSCL was purchased from Northway Lignin Chemical as Polybind 300 (liquid). Before use, the SCL was dried in a100/C176C laboratory oven until dry. The dry weight of the lignin was *50 % of the as-received wet lignin weight." 218 453 W1964811855.pdf 2 5 separator 0.8874916 ¶ 453 455 W1964811855.pdf 2 6 text 0.99903315 "Medium molecular weight CS (viscosity average Mw190–310 kDa, 75–85 % deacetylation) and 5,000,000 Mw PEO were purchased from Sigma-Aldrich and used as- received without further purification. Acetic acid ( C99.5 % pure) was purchased from Acros Organics. Deionized water was used as the primary solvent." 455 765 W1964811855.pdf 2 7 separator 0.99646294 ¶ 765 767 W1964811855.pdf 2 8 title 0.95797 Method 767 774 W1964811855.pdf 2 9 separator 0.99012184 ¶ 774 776 W1964811855.pdf 2 10 title 0.7315926 Solution preparation 776 797 W1964811855.pdf 2 11 text 0.99972874 "Various electrospinning solutions were prepared from a blend of SCL, CS and PEO. All polymer concentrations arereported as w/v % (g/ml). The solutions were prepared with 0.6 % PEO, 1.5 % chitosan and 1.5, 2.0, 2.5, or 3.0 % SCL. Initially, CS and PEO were dissolved in acetic acidand deionized water, while SCL was dissolved in deionized water. The two solutions were then mixed under constant stirring conditions to achieve the desired polymer con-centrations in a 40(v/v) % acetic acid solution. The solu- tions are labelled as 1.5, 2.0, 2.5 and 3.0L based on their respective lignin content." 797 1405 W1964811855.pdf 2 12 separator 0.9966967 ¶ 1405 1407 W1964811855.pdf 2 13 title 0.9888391 Electrospinning 1407 1423 W1964811855.pdf 2 14 separator 0.9947196 ¶ 1423 1425 W1964811855.pdf 2 15 text 0.99977 "Electrospinning was performed in a NANON-01A elec- trospinning setup, MECC Co., Ltd. Japan. A custom-made plate collector, which allowed for a variation in the heightof the collector (the collector, which came with the machine had a fixed height), was employed to achieve a greater working distance. Solutions were electrospun usinga 24 gauge needle, 14 kV applied voltage, 0.1 ml/h flow rate and a 22.5 cm working distance in ambient conditions." 1425 1880 W1964811855.pdf 2 16 separator 0.9964572 ¶ 1880 1882 W1964811855.pdf 2 17 title 0.98733723 Characterization 1882 1899 W1964811855.pdf 2 18 separator 0.9948729 ¶ 1899 1901 W1964811855.pdf 2 19 text 0.9996304 "Solution viscosities were measured using a Brookfield DV- II?Pro viscometer at room temperature with a #4 spindle at 100 rpm. Each measurement had an inherent 1 % error,and three independently prepared solutions were measured to calculate an average and standard deviation. Solution surface tensions were measured using the Du Nuoy ring method with the ring attached to a microbalance at roomtemperature where the ring was slowly pulled out of the solution, and the surface tension being recorded just before the ring broke contact with the solution surface. Eachmeasurement had an inherent 5 % error, and three inde- pendently prepared solutions were measured to calculate an average and standard deviation. The resulting fibre mor- phologies were analysed using an FEI - Inspect S50 scanning electron microscope (SEM) operated at 15 kV.The fibres were sputter-coated with *20 nm of gold to make them conductive. The obtained SEM images were further analysed using the ImageJ software to measure thefibre diameters using over 100 measurements for each formulation to obtain an average and standard deviation. A model TCS SP5 II laser scanning confocal microscope(LCM) (Leica Microsystems, Exton, PA) was used in the ‘xyk’ mode to obtain fluorescence emission spectra of the resulting fibres and the constituent materials as well as toresolve the spatial distribution of the constituent materials within the fibres. Thermal characteristics of the fibres were measured using a TA instruments thermogravimetric ana-lyser (TGA) Q500. TGA thermograms were obtained from 20 to 800 /C176C at a ramp rate of 10 /C176C/min. Heating took place in a nitrogen atmosphere injected at a flow rate of15 ml/min. Structural characteristics of the fibres and constituent polymers were investigated using a Thermo Scientific Nicolet 6700 Fourier transform infrared (FTIR)spectrometer with a GladiATR single reflection ATR accessory operated between 400 and 4000 cm -1. The spectra were collected at a resolution of 4 cm-1with 32 scans per sample at room temperature. Elemental analysis was performed on the fibres using a model S3400-N SEM (Hitachi Hitachi-Technologies, Pleasanton, CA) coupled toa Noran System 6 energy dispersive x-ray spectrometer (Thermo Electron Corp., Madison, WI). To confirm that the resultant fibres were composed of PECs, the fibres weresoaked in water for at least a day and analysed through SEM, LCM, EDS, FTIR and TGA." 1901 4380 W1964811855.pdf 2 20 separator 0.99634826 ¶ 4380 4382 W1964811855.pdf 2 21 title 0.98866224 Result and discussion 4382 4404 W1964811855.pdf 2 22 separator 0.9946275 ¶ 4404 4406 W1964811855.pdf 2 23 text 0.90492797 "Polyelectrolyte complex of sodium carbonate lignin and chitosan" 4406 4472 W1964811855.pdf 2 24 separator 0.8756345 ¶ 4472 4474 W1964811855.pdf 2 25 text 0.99970263 "Based on the polyionic nature of the SCL and CS, it was expected that they would form PECs with each other (Fig. 1). It was undesirable for them to form PECs in solution as it would cause clogging of the needle. It was observed that above an acetic acid concentration of 40 %" 4474 4758 W1964811855.pdf 2 26 paratext 0.9803751 inJ Mater Sci (2014) 49:7949–7958 7951 4758 4797 W1964811855.pdf 2 27 separator 0.649993 4797 4798 W1964811855.pdf 2 28 paratext 0.76369536 ¶ 123 4798 4803 W1964811855.pdf 2 0 title 0.57475334 data 0 4 W3125451002.pdf 0 1 separator 0.96550584 ¶ 4 6 W3125451002.pdf 0 2 title 0.9847874 Data Descriptor 6 22 W3125451002.pdf 0 3 separator 0.6599376 22 23 W3125451002.pdf 0 4 title 0.9339447 "¶ Sigfox and LoRaWAN Datasets for Fingerprint Localization in Large Urban and Rural Areas" 23 114 W3125451002.pdf 0 5 separator 0.9888369 ¶ 114 116 W3125451002.pdf 0 6 contact 0.9886151 "Michiel Aernouts1,*ID, Rafael Berkvens1ID, Koen Van Vlaenderen2and Maarten Weyn1ID 1IDLab—Faculty of Applied Engineering, University of Antwerp—imec, Groenenborgerlaan 171, 2020 Antwerp, Belgium; rafael.berkvens@uantwerpen.be (R.B.); maarten.weyn@uantwerpen.be (M.W.) 2Sensolus NV , Rijsenbergstraat 148, 9000 Ghent, Belgium; koen@sensolus.com *Correspondence: michiel.aernouts@uantwerpen.be" 116 516 W3125451002.pdf 0 7 separator 0.9242439 ¶ 516 518 W3125451002.pdf 0 8 paratext 0.97552717 "Received: 16 March 2018; Accepted: 5 April 2018; Published: 10 April 2018 /gid00030/gid00035/gid00032/gid00030/gid00038/gid00001/gid00033/gid00042/gid00045 /gid00001 /gid00048/gid00043/gid00031/gid00028/gid00047/gid00032/gid00046" 518 752 W3125451002.pdf 0 9 separator 0.994113 ¶ 752 754 W3125451002.pdf 0 10 text 0.9985529 "Abstract: Because of the increasing relevance of the Internet of Things and location-based services, researchers are evaluating wireless positioning techniques, such as fingerprinting, on Low Power Wide Area Network (LPWAN) communication. In order to evaluate fingerprinting in large outdoor environments, extensive, time-consuming measurement campaigns need to be conducted to create useful datasets. This paper presents three LPWAN datasets which are collected in large-scale urban and rural areas. The goal is to provide the research community with a tool to evaluate fingerprinting algorithms in large outdoor environments. During a period of three months, numerous mobile devices periodically obtained location data via a GPS receiver which was transmitted via a Sigfox or LoRaWAN message. Together with network information, this location data is stored in the appropriate LPWAN dataset. The first results of our basic fingerprinting implementation, which is also clarified in this paper, indicate a mean location estimation error of 214.58 m for the rural Sigfox dataset, 688.97 m for the urban Sigfox dataset and 398.40 m for the urban LoRaWAN dataset. In the future, we will enlarge our current datasets and use them to evaluate and optimize our fingerprinting methods. Also, we intend to collect additional datasets for Sigfox, LoRaWAN and NB-IoT." 754 2130 W3125451002.pdf 0 11 separator 0.9882312 ¶ 2130 2132 W3125451002.pdf 0 12 paratext 0.9746693 "Dataset: 10.5281/zenodo.1193562 Dataset License: CC-BY" 2132 2189 W3125451002.pdf 0 13 separator 0.8939135 ¶ 2189 2191 W3125451002.pdf 0 14 paratext 0.70106804 Keywords: IoT; LPWAN; Sigfox; LoRaWAN; localization; fingerprinting 2191 2258 W3125451002.pdf 0 15 separator 0.99604774 ¶ 2258 2260 W3125451002.pdf 0 16 title 0.98599845 1. Introduction 2260 2276 W3125451002.pdf 0 17 separator 0.9956542 ¶ 2276 2278 W3125451002.pdf 0 18 text 0.9996033 "The growing importance of the Internet of Things (IoT) creates a rapidly increasing necessity for wide area communication standards that guarantee reliable connectivity between a multitude of IoT devices. For this purpose, researchers have been developing various Low Power Wide Area Network (LPWAN) standards. IoT requires LPWAN standards to support long-range communication and high scalability of end-devices at a low cost. Also, ubiquitous indoor and outdoor connectivity as well as ultra-low power consumption are crucial aspects for reliable, transparent IoT applications that work for years on small batteries [ 1]. To meet these requirements, numerous measures have to be considered for LPWAN design, such as modulation techniques, network topology, hardware complexity, use of radio frequent spectrum and regulations. In general, a trade-off between these measures and data rate has to be made [2]." 2278 3204 W3125451002.pdf 0 19 separator 0.9108067 ¶ 3204 3206 W3125451002.pdf 0 20 text 0.99966145 "Context-awareness is an important aspect of IoT applications. This means that, depending on the application, an IoT device can alter its behavior based on the measurements it has conducted in its environment. In order to create context-awareness for IoT applications, the location of the device has" 3206 3509 W3125451002.pdf 0 21 separator 0.83689183 ¶ 3509 3511 W3125451002.pdf 0 22 paratext 0.986761 Data 2018 ,3, 13; doi:10.3390/data3020013 www.mdpi.com/journal/data 3511 3579 W3125451002.pdf 0 0 text 0.97618914 "Siqueira Filho et al.similar behavior between the methods, but with divergence in values." 0 92 W2099880065.pdf 4 1 separator 0.904845 ¶ 92 94 W2099880065.pdf 4 2 text 0.9940379 "At points on the welding fillet (points 11, 12 and 13) it was shown that the stresses measured by the method of X-ray diffraction values are quite different from those obtained by the method of coordinate measuring machine." 94 327 W2099880065.pdf 4 3 separator 0.94116396 ¶ 328 330 W2099880065.pdf 4 4 text 0.99661535 "Measurements made by the method of X-ray diffraction showed inconsistent values, requiring new measurements to better observations." 330 468 W2099880065.pdf 4 5 separator 0.99627954 ¶ 468 470 W2099880065.pdf 4 6 title 0.9859507 4. Conclusions 470 485 W2099880065.pdf 4 7 separator 0.9954935 ¶ 485 487 W2099880065.pdf 4 8 text 0.9903925 "The results obtained with the coordinate machine measurements proved to be quite consistent, as compared to values obtained by X-ray diffraction, especially for the longitudinal stresses. " 487 685 W2099880065.pdf 4 9 separator 0.58322257 ¶ 685 686 W2099880065.pdf 4 10 text 0.9903225 "The transverse residual stress present different values between the two methods. Although the difference between these methods showed similar behavior either for points at a distance 2.5 mm or 5.0 mm from weld fillet. This new method showed satisfactory results, allowing a greater range of options for measurements in the residual stresses resulting from the welding process." 686 1080 W2099880065.pdf 4 11 separator 0.9968102 ¶ 1080 1082 W2099880065.pdf 4 12 title 0.91514724 Acknowledgements 1082 1099 W2099880065.pdf 4 13 separator 0.9923574 ¶ 1099 1101 W2099880065.pdf 4 14 text 0.9864405 "Thanks to FACEPE (Science and Technology Foundation of Pernambuco) and CNPQ (National Council of Research) for financial assistance during this work.Comparing the longitudinal stresses measured in points 1 to 10 in the heat affected zone, HAZ (Figures 4 and 5) with the Transverse residual stresses at the same points (Figures 6 and 7), we observe that the longitudinal stresses we obtain result very similar values absolute in both methods of measurements, whereas in transverse notes there is a Figure 7. Transverse residual stresses obtained by X-ray diffraction and displacement in coordinate measuring machine (as showed in graphic the uncertainty measurements are very small, so the points are not can be observed), points a distance 5.0 mm from weld fillet." 1101 1896 W2099880065.pdf 4 15 separator 0.99614936 ¶ 1896 1898 W2099880065.pdf 4 16 title 0.71846616 References 1898 1909 W2099880065.pdf 4 17 separator 0.9876303 ¶ 1909 1911 W2099880065.pdf 4 18 bibliography 0.9970006 "1. Lu J. Handbook of Measurement of Residual Stresses . SEM Inc.; 1996. 254 p." 1911 1993 W2099880065.pdf 4 19 separator 0.67546964 ¶ 1993 1995 W2099880065.pdf 4 20 bibliography 0.9966924 "2. Rodacoski MR . Medição de Tensões Residuais com Holografia Eletrônica. 2002." 1995 2078 W2099880065.pdf 4 21 separator 0.61064285 ¶ 2078 2080 W2099880065.pdf 4 22 bibliography 0.99743766 "3. Benning IO. Non-destructive determination of Load and Residual Stresses by the X-ray stress method. The Rigaku Journal . 1989; 6(2)." 2080 2222 W2099880065.pdf 4 23 separator 0.9186468 ¶ 2222 2224 W2099880065.pdf 4 24 bibliography 0.99703646 "4. Bureau Veritas. Rules and Regulation for the Classification of Ships and Offshore Installation-Materials. Section 2. NR. 216DNCRO2E; 1997." 2224 2372 W2099880065.pdf 4 25 separator 0.974802 ¶ 2372 2374 W2099880065.pdf 4 26 bibliography 0.9957863 "5. Mercantil Brasileira de Aço – MBA. Available from:: www.mba -aco.com.br/pdf/chapas_estruturas_navais_alta_ resistencia.pdf . Acess in: 11/03/2010." 2374 2530 W2099880065.pdf 4 27 separator 0.95944774 ¶ 2530 2532 W2099880065.pdf 4 28 bibliography 0.99741906 "6. American Welding Society - AWS. AWS A5.18 : Specification for Carbon Steel Electrodes and Rods for Gas Shielded Arc Welding. AWS; 2001." 2532 2677 W2099880065.pdf 4 29 separator 0.96622324 ¶ 2677 2679 W2099880065.pdf 4 30 bibliography 0.99764866 "7. Lu J, Bouhelier C, Lieurade HP, Baralle D, Miege B and Flevanot JF. Study of Residual Welding Stress Using Step- by-step Hole Drilling and Xray Diffraction Method . Welding in the World . 1994; 33(2):118-128.8. Okumura T and Tanigusgi C. Engenharia de Soldagem e Aplicações. Rio de Janeiro: Livros Técnicos e Científicos Ed.; 1982." 2679 3028 W2099880065.pdf 4 31 separator 0.970622 ¶ 3028 3030 W2099880065.pdf 4 32 bibliography 0.99765897 "9. Callister Junior WD. Ciência e Engenharia de Materiais : Uma Introdução. 5. ed. Rio de Janeiro: Livros Técnicos e Científicos Ed.; 2002." 3030 3176 W2099880065.pdf 4 33 separator 0.9777142 ¶ 3176 3178 W2099880065.pdf 4 34 bibliography 0.99744827 "10. Guimarães PB, Pedrosa PMA, Yadava PY , Barbosa JMA, Siqueira Filho A V and Ferreira RAS. Determination of the Residual Stresses from a Temperature Field Numerically Obtained , 2012. In publication." 3178 3389 W2099880065.pdf 4 35 separator 0.965395 ¶ 3389 3391 W2099880065.pdf 4 36 bibliography 0.99751914 "11. Oliveira GLG, Hélio CM and Jesualdo PF. Avaliação das Tensões Residuais em Tubos de Pequeno Diâmetro Soldados pelo Processo TIG Orbital. Soldagem & Inspeção . 2009; 14(2)." 3391 3574 W2099880065.pdf 4 37 separator 0.95902663 ¶ 3575 3577 W2099880065.pdf 4 38 bibliography 0.98437643 "Available from: . Access in: 23/08/2010. Comparative." 3577 3719 W2099880065.pdf 4 39 separator 0.98781085 ¶ 3719 3721 W2099880065.pdf 4 40 bibliography 0.99766386 "12. Lima EPR, Sanguinetti Ferreira, RA, Quadros NF and Yadava YP. Estudo dos aspectos cinéticos e mofológicos durante recristalização da liga AA8011 . Revista Iberoamericana de Ingenharia Mecânica. 2006; 10(1):131-137." 3721 3950 W2099880065.pdf 4 41 separator 0.9833032 ¶ 3950 3952 W2099880065.pdf 4 42 bibliography 0.9974796 "13. Siqueira Filho A V , Guimarães PB, Pedrosa PMA, Yadava PY , Rolim TL and Ferreira RAS. Effect of Anisotropy in Heat Treatment Stress Relieving , 2012. In publication.326" 3952 4132 W2099880065.pdf 4 43 separator 0.97672105 ¶ 4132 4134 W2099880065.pdf 4 44 bibliography 0.98054594 Materials Research 4134 4153 W2099880065.pdf 4 0 paratext 0.93410856 7 0 1 W3012489676.pdf 6 1 separator 0.99515283 ¶ 3 5 W3012489676.pdf 6 2 text 0.9997384 instructions of the coprocessor 1% of time (one instruction of the scheduling per 100 instructions), then the probability of a conflict occurrence is 0.01% for dual-core CPUs. So the conflict would occur very rarely but still it has to be taken into account. If a conflict occurs, it is resolved dynamically by the semaphore module. This module is responsible for choosing which CPU core can use the coprocessor at the corresponding time. The second core will use the coprocessor 2 clock cycles later and thus, it must be stalled for 2 clock cycles in that case. The Semaphore module for dual-core CPU systems consists mainly of multiplexers for selecting the instruction. In addition to that, there is only one D Flip-Flop (DFF) added for remembering whether the last conflict-winning core was CPU core 1 or CPU core 2. In the case of a conflict occurrence, the multiplexer is also controlled by the output of the DFF. The best-case execution time is one clock cycle. However, it is important to keep in mind that the main target is hard real-time systems, where the worst-case execution time should be taken in consideration instead of the best case or average execution time. The worst-case execution time of the semaphore approach is four clock cycles because in the worst-case scenario, a conflict occurs every clock cycle. 6 1335 W3012489676.pdf 6 3 caption 0.9885192 Fig. 9 shows the logic circuit that implements Semaphore module handling conflicts for two CPU cores. 1335 1437 W3012489676.pdf 6 4 separator 0.995002 ¶ 1438 1440 W3012489676.pdf 6 5 caption 0.9928714 Fig. 9. Semaphore module circuit for dual-core systems. 1441 1497 W3012489676.pdf 6 6 text 0.9988485 For quad-core systems, the situation is much more complicated because there are more possible combinations of the conflicts that may occur. Even bigger conflicts (i.e. three or more CPU cores intending to use the coprocessor at the same time) can occur too. There are eleven possible combinations of conflicts in total, represented by the CPU core numbers. There exist six versions of conflicts when two CPU cores are in conflict: CPU core 1 and CPU core 2 conflict named as 1-2, CPU core 1 and CPU core 3 named as 1-3, CPU core 1 and CPU core 4 named as 1-4, CPU core 2 and CPU core 3 named as 2-3, CPU core 2 and CPU core 4 named as 2-4, CPU core 3 and CPU core 4 named as 3-4. These four versions of conflicts can occur when three CPU cores are trying to use the scheduler at the same time: CPU core 1, CPU core 2 and CPU core 3 conflict named as 1-2-3, CPU core 1, CPU core 2 and CPU core 4 conflict named as 1-2-4, CPU core 1, CPU core 3 and CPU core 4 conflict named as 1-3-4 and CPU core 2, CPU core 3 and CPU core 4 conflict named as 2-3-4. The last possible combination is when all four CPU cores are trying to use the scheduler at the same time, which is named as 1-2-3-4. There are two requirements for the semaphore module, primary and secondary. The primary requirement is that there is specified a maximum possible number of delays (CPU stalls) caused by the conflicts and that this number is relatively low. Such a requirement is crucial because the scheduler is intended for real-time systems. The secondary requirement is fairness from the point of view of the CPU cores – each CPU core has approximately the same amount of possibilities to win to use the scheduler instantly [37]. The proposed solution for the new Semaphore module consists of a 2-bit counter that is used for representation of four states. These four states are called: 1234, 2143, 3412 and 4321. Each of these states implicitly specifies the priority order that is used for selecting a winner whenever any of the eleven possible conflicts occurs. For example, the 1234 state means that the CPU core 1 has higher priority than core 2, CPU core 2 has higher priority than core 3, and CPU core 3 has higher priority than core 4. Whenever a conflict occurs, the state is changed to the next one by incrementing the 2-bit counter. We decided to reduce the total number of 24 possible permutations or priority orders to only 4 orders defined by the four states because in this way, the state machine responsible for decision of which CPU wins the conflict is much simpler, resulting in simpler design and smaller hardware. The four orders were chosen so that these orders are symmetric, fair and they are rotating after every conflict. Whenever a conflict occurs, the order is changed to the next order by updating the state machine moving from the current state to the next state. The states are specified by 2-bit counter in the following way [37]: • value “00” represents state/order 1234. The next value is “01”. • value “01” represents state/order 2143. The next value is “10”. • value “10” represents state/order 3412. The next value is “11”. • value “11” represents state/order 4321. The next value is “00”. All combinations of conflicts with respect to the actual state and the corresponding winners are listed in Table I. Each line of the table represents a possible scenario of conflicting CPU cores. The columns represent the four possible orders, where one of them is selected at a given time depending on the current state of the state machine. One can observe that both requirements for the Semaphore are met because the maximum possible number of losses for any CPU core is three in a row (i.e. the CPU core can lose 0, 1 2 or 3 times at most), and the winning of CPU cores is evenly distributed. Due to the rotating behavior of states/orders, it is guaranteed that one instruction will take 2M clock cycles in the worst-case scenario (the case when all CPU cores want to use the scheduler all the time), where M is the number of CPU cores. The best-case scenario is 2 clock cycles. Thus, for quad-core CPUs, one instruction can take 2 to 8 clock cycles depending on the occurrence of the conflicts. 1497 5695 W3012489676.pdf 6 7 title 0.99147344 TABLE I. TABLE OF WINNERS FOR QUAD-CORE SEMAPHORE 5695 5746 W3012489676.pdf 6 8 separator 0.99731326 ¶ 5747 5749 W3012489676.pdf 6 0 text 0.99946773 "ON. 100 ml of TSB +YE medium was inoculated with 1 ml of ON-culture and grown to log phase followed by induction of protein expression by addition of IPTG to a final concentration of 1 mM. The cultivations were incubated at 25 uC ON and harvested by centrifugation (2700 g, 15 min, 4 uC). The pellets were resuspended in 10 ml wash buffer (50 mM sodium phosphate, 6 M Urea, 300 mM NaCl, pH 7.5) and disrupted by sonication (Vibra Cell; Sonics and materials Inc., Danbury, CT, USA). Proteins were recovered from the supernatant after a subsequent centrifugation to remove cell debris (10000 g, 20 min,4uC). The samples were filtered (0.45 mm) and loaded on a 1 ml Talon metal affinity resin column (Clontech Laboratories, CA, USA) equilibrated with eight column volumes (CV) of wash buffer." 0 813 W2077893947.pdf 2 1 separator 0.85719484 ¶ 813 815 W2077893947.pdf 2 2 text 0.9993823 "The column was washed with ten CV of wash buffer followed by elution in ten (1 ml) fractions (50 mM NaAc, 6 M Urea, 100 mM NaCl, 30 mM HAc, pH 4.5). Protein concentrations were estimated from absorbance measurements at 280 nm (Eppendorf Biophotometer) and the most concentrated fractions were analyzed by SDS-PAGE on Novex Bis-Tris 4–12% gradient gels using the Novex system (Invitrogen, CA, USA). Buffer exchange was done by extensive dialysis at 4 uC against HEPES buffered saline (HBS-EP; 10 mM HEPES, 150 mM NaCl, 3.4 mM EDTA, 0.05% P20, pH 7.4). Concentrations were determined by amino acid analysis (Aminosyraanalyscentralen, Uppsala, Sweden) and molecular weights were verified by liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS) on a 6520 Accurate Mass Q-TOF LC/MS (Agilent Technologies, CA, USA)." 815 1676 W2077893947.pdf 2 3 separator 0.99584997 ¶ 1676 1678 W2077893947.pdf 2 4 title 0.99091583 Biosensor analysis of first generation binders 1678 1725 W2077893947.pdf 2 5 separator 0.99383414 ¶ 1725 1727 W2077893947.pdf 2 6 text 0.9996917 "Selected ABD-variants were screened for binding to HSA and TNF- ausing surface plasmon resonance (SPR) with a BIAcore H 2000 instrument (Biacore, Uppsala, Sweden). HSA and TNF- a (both at 10 mgm l21in 10 mM NaAc, pH 4.5) were immobilized (2000 response units (RU) each) on a Biacore CM5 sensor chip by standard amine coupling. ABD-variants were serially injected over both flow cells at concentrations ranging from 1–5 mM with a flow rate of 50 ml min21at 25 uC using HBS-EP as running buffer. The surfaces were regenerated between injections using 10 ml pulses of 10 mM HCl. The response from a reference flow cell was subtracted and the results were analyzed using BIAevaluation 3.2 software." 1727 2444 W2077893947.pdf 2 7 separator 0.9429523 ¶ 2444 2446 W2077893947.pdf 2 8 text 0.9997501 "The two candidates that showed binding to TNF- ain the screening (ABD TNF1 and ABD TNF2 ) were immobilized, by amine coupling by the procedure described above, to 400 RU each on a new CM5 chip. TNF- awas injected (50 ml min21at 25 uC using HBS-EP as running buffer) at concentrations ranging from 3.2– 9960 nM. Injections were performed in duplicates and the kinetic constants (k aand k d) were determined using BIAevaluation 3.2 software. To determine the affinity to HSA, both ABD-variants as well as the non-randomized ABD were injected in duplicates, at concentrations ranging from approximately 1–3000 nM (up to 250 nM for ABD), over a surface immobilized with HSA (2000 RU). Kinetic constants were determined as above and equilibrium responses (RU) from all experiments were fitted to a 1:1 binding model using GraphPad Prism in order to determine the K Dvalues." 2446 3341 W2077893947.pdf 2 9 separator 0.9972166 ¶ 3341 3343 W2077893947.pdf 2 10 title 0.9943684 Subcloning to staphylococcal display vector 3343 3387 W2077893947.pdf 2 11 separator 0.9924502 ¶ 3387 3389 W2077893947.pdf 2 12 text 0.99971265 "The gene sequences encoding the non-randomized ABD and the two selected bispecific ABD-variants were PCR-amplified from their phage display vector constructs and ligated to a modifiedversion of the previously described staphylococcal display vector pSCZ1 [22]. In the new vector (denoted pSCABD1), the albumin- binding protein (ABP) that was previously used for normalizationof surface expression was replaced with a dimeric construct of an IgG-binding domain (Z 2) derived from staphylococcal protein A." 3389 3906 W2077893947.pdf 2 13 separator 0.5006163 3906 3907 W2077893947.pdf 2 14 text 0.9920328 "¶ E. coli RR1DM15 was used as host for plasmid construction and preparation, and the constructs were transformed to electrocom- petent Staphylococcus carnosus TM300 according to previously described protocol [23]." 3907 4126 W2077893947.pdf 2 15 separator 0.9970845 ¶ 4126 4128 W2077893947.pdf 2 16 title 0.99387205 Cell labeling and flow-cytometric analysis 4128 4171 W2077893947.pdf 2 17 separator 0.99500334 ¶ 4171 4173 W2077893947.pdf 2 18 text 0.99970835 "Staphylococcal cells displaying ABD-variants were inoculated to 10 ml TSB +YE with 10 mgm l21chloramphenicol and grown ON at 37 uC and 150 rpm. From ON cultures, approximately 106cells were washed with 1 ml PBS supplemented with 0.1% Pluronic H F108 NF Surfactant (PBSP; pH 7.4; BASF Corporation, Mount Olive, NJ). The cells were pelleted by centrifugation (3500 g, 4 uC, 6 min) and resuspended in 100 ml of PBSP containing twelve different concentrations of biotinylated TNF- a(4.3–12900 nM) or fluorophore-conjugated HSA (1.25–2500 nM; 10–20000 nM for ABD TNF1 ). Equilibrium binding was reached by incubation at RT for 1 h with gentle mixing. The cells were washed with 1 ml ice- cold PBSP, followed by incubation on ice in 100 ml ice-cold PBSP containing 1.25 mgm l21streptavidin-Alexa Fluor 488 conjugate (Invitrogen) for 15 min (for HSA-binding the secondary incuba- tion was omitted). Following one wash with 1 ml ice-cold PBSP, cells were resuspended in 300 ml ice-cold PBSP prior to flow- cytometric analysis. The mean fluorescence intensity (MFI) was measured using a FACS Vantage SE (BD Biosciences, San Jose, CA) flow cytometer. MFI data was fitted to a 1:1 binding model using GraphPad Prism in order to determine the K Dvalues." 4173 5453 W2077893947.pdf 2 19 separator 0.9968555 ¶ 5453 5455 W2077893947.pdf 2 20 title 0.9937574 Second-generation library construction and cloning 5455 5506 W2077893947.pdf 2 21 separator 0.99440694 ¶ 5506 5508 W2077893947.pdf 2 22 text 0.99973696 "Two different degenerate oligonucleotides (Scandinavian Gene Synthesis AB, Ko ̈ping, Sweden), encoding helix one and helix three, respectively, with complementary regions encoding the non- randomized second helix of ABD were annealed and extended bysix cycles of PCR using AmpliTaqGold DNA polymerase (Applied Biosystems). Flanking restriction sites for XhoI and NheI were introduced in an additional PCR-reaction (15 cycles) using a new primer pair. The PCR-products were purified with QIAquick PCR Purification Kit (Qiagen) according to the supplier’s recommendations. The purified pool of randomized library fragment was digested with restriction enzymes XhoI and NheI (New England Biolabs) and purified as above. The staphylococcal display vector, pSCABD1, was prepared from E. coli RR1DM15 and purified using Jetstar Maxi Kit (Genomed, Bad Oeynhausen, Germany). The vector was digested with the same enzymes and purified using preparative gel electrophoresis on a 1% agarose gel." 5508 6521 W2077893947.pdf 2 23 separator 0.90828145 ¶ 6521 6523 W2077893947.pdf 2 24 text 0.9988853 "Ligation of pSCABD1 with the randomized library fragments was performed at a 1:20 molar ratio of vector to fragment using T4 DNA ligase (New England Biolabs). The ligation mixture was purified using QIAquick Gel Extraction Kit according to the supplier’s recommendations prior to transformation to electro- competent E. coli DH5acells. Individual clones, plated directly after transformation, were PCR-amplified for sequence verifica- tion using BigDye Thermo Cycle Sequencing reactions and an ABI Prism H3700 instrument (Applied Biosystems). Plasmids were prepared from ON cultures of E. coli using Jetstar Maxi Kit (Genomed) and transformed to electrocompetent S. carnosus as described above. The staphylococcal library is hereinafter denoted Sc:ABD TNFlib ." 6523 7310 W2077893947.pdf 2 25 separator 0.9965261 ¶ 7310 7312 W2077893947.pdf 2 26 title 0.9935572 Cell labeling and FACS 7312 7335 W2077893947.pdf 2 27 separator 0.9952608 ¶ 7335 7337 W2077893947.pdf 2 28 text 0.9995282 "Cells, approximately 50 times the library size, were labeled basically as described above, but with the addition of fluorescently conjugated IgG in the second incubation for monitoring of theEngineering Bispecificity into a Single Domain" 7337 7579 W2077893947.pdf 2 29 separator 0.9618852 ¶ 7579 7581 W2077893947.pdf 2 30 paratext 0.98537517 PLoS ONE | www.plosone.org 3 October 2011 | Volume 6 | Issue 10 | e25791 7581 7654 W2077893947.pdf 2 0 table 0.55116975 "a85aS122 ea2C~0!~12t/t0!D, ~20! b85b21 eaC~0!~12t/t0!, ~21! e85e F" 0 76 W1976725956.pdf 3 1 math 0.69870585 "122 ea2C~0!~12t/t0!G. ~22!" 76 104 W1976725956.pdf 3 2 separator 0.98130536 ¶ 104 106 W1976725956.pdf 3 3 text 0.99933994 "Although we admit that this particularly simple renormal- ization scheme is model dependent, the procedure is quitegeneral and its predictions are quite robust, as shown in fol-lowing sections, when they are statistically compared withnumerical simulations of the original stochastic model." 106 399 W1976725956.pdf 3 4 separator 0.9691639 ¶ 399 401 W1976725956.pdf 3 5 text 0.99868107 "It is clear that these results have been obtained for small noise intensities and temporal correlations and thereforesome inconsistencies should be expected for large values ofthese parameters. In order to get a better analytical conver-gence we further propose a standard analytic regularizationof the previous first-order expressions. The simplest regular- ization of the tdependence, giving the deterministic limit when t!0, would be expressed by ~see Fig. 2 !" 401 872 W1976725956.pdf 3 6 separator 0.9897115 ¶ 872 874 W1976725956.pdf 3 7 math 0.4899318 874 875 W1976725956.pdf 3 8 table 0.4531921 a 875 876 W1976725956.pdf 3 9 math 0.47789317 85 876 878 W1976725956.pdf 3 10 table 0.47708398 aS122CR 878 885 W1976725956.pdf 3 11 math 0.49752975 ~0! 885 888 W1976725956.pdf 3 12 table 0.52647054 "¶ ea2D, ~23! b85b2CR~0! ea, ~24! ¶" 888 927 W1976725956.pdf 3 13 math 0.60852015 "e85e S122CR~0! ¶" 927 946 W1976725956.pdf 3 14 text 0.87508446 "ea2D, ~25!where for simplicity we have introduced the effective param- eterCR(0) into the renormalized expressions for the model parameters, " 946 1092 W1976725956.pdf 3 15 separator 0.46148115 ¶ 1092 1093 W1976725956.pdf 3 16 math 0.76267606 "CR~0!5C~0! @11t/t0~l!#. ~26!" 1093 1124 W1976725956.pdf 3 17 separator 0.8827798 ¶ 1124 1126 W1976725956.pdf 3 18 text 0.9978586 "This is another relevant effective parameter in our analytical approach. It can be understood as a renormalization of thenoise intensity, which incorporates the influence of the three parameters of the noise @remember that C(0); s2/ld#. The white noise intensity is trivially recovered for t!0 leading to the well-known Stratonovich contribution, and the deter- ministic limit is obtained as s2!0,t!‘,o rl!‘." 1126 1546 W1976725956.pdf 3 19 separator 0.952325 ¶ 1546 1548 W1976725956.pdf 3 20 text 0.9976832 "The behavior of t0andCR(0) as a function of the noise parameters will help us in the interpretations and predictionsrelevant to the phenomena in noisy excitable systems re-ported in the following sections." 1548 1756 W1976725956.pdf 3 21 separator 0.9968792 ¶ 1756 1758 W1976725956.pdf 3 22 title 0.9938568 III. NOISE-INDUCED EXCITABILITY TRANSITIONS 1758 1802 W1976725956.pdf 3 23 separator 0.9960015 ¶ 1802 1804 W1976725956.pdf 3 24 text 0.9993504 "Quite diverse are the wave propagation phenomenologies that can be found in spatially extended active media. In thissection we focus on the most paradigmatic examples, i.e.,single front propagation ~either with or without free ends !, spiral waves or target patterns. Our goal at this point is toshow that external distributed fluctuations can be effectivelyused to tune the global excitability properties of the medium,and in turn modify the conditions under which the differentregimes of wave propagation are observed.Although such aneffect will naturally depend on the different parameters of thefluctuations, i.e, their intensity and length and time correla-tions, we will restrict ourselves in this section to the consid-eration of noncorrelated, neither temporal nor spatial, noise.In this way, we hope to stress the generic nature of what wehave called noise-induced excitability transitions and, at thesame time, focus on the role of the fluctuation intensity as" 1804 2776 W1976725956.pdf 3 25 separator 0.991146 ¶ 2776 2778 W1976725956.pdf 3 26 caption 0.9013307 "FIG. 2. Parameters of the effective model Eqs.~23!–~25!vs the temporal correlation of the noise ( t). In this and following figures, the sym- bols s.u. and t.u. correspond, respectively, to thedimensionless spatial and temporal units used forthe model in Eq. ~1!. Parameter values are a" 2778 3070 W1976725956.pdf 3 27 separator 0.33604628 ¶ 3070 3072 W1976725956.pdf 3 28 caption 0.38680708 5 3072 3074 W1976725956.pdf 3 29 math 0.52876425 "0.7,b50.1, e50.02,D51,C(0)50.004, C9(0)520.8, and t050.0047" 3074 3137 W1976725956.pdf 3 30 caption 0.32339895 3137 3138 W1976725956.pdf 3 31 math 0.43850097 t.u 3138 3141 W1976725956.pdf 3 32 text 0.25150794 . 3141 3142 W1976725956.pdf 3 33 paratext 0.9847699 S. ALONSO, F. SAGUE ́S, AND J. M. SANCHO PHYSICAL REVIEW E 65066107 3142 3208 W1976725956.pdf 3 34 separator 0.6250311 ¶ 3208 3210 W1976725956.pdf 3 35 paratext 0.9847286 066107-4 3210 3219 W1976725956.pdf 3 0 paratext 0.9905109 Remote Sens. 2023 ,15, 962 2 of 13 0 34 W4319965899.pdf 1 1 separator 0.98969305 ¶ 34 36 W4319965899.pdf 1 2 text 0.9991826 "explains the relationship between image intensity and the motion of a structure. It is suitable for cases in which there are no artificial targets, and can result in full-field mode shapes." 36 226 W4319965899.pdf 1 3 separator 0.6388517 ¶ 226 228 W4319965899.pdf 1 4 text 0.9995708 "The phase-based approach [ 11] is used to rapidly recover the displacements from the phase space of the images. Compared to the optical-flow-based method, the phase-based approach is frequently more resilient to noise and disturbances." 228 467 W4319965899.pdf 1 5 separator 0.82406914 ¶ 467 469 W4319965899.pdf 1 6 text 0.9997324 "In practice, the long-term monitored structure is usually subjected to ambient exci- tation only, so its vibration is slight [ 12]. Conventionally, for the measurement of small- amplitude dynamic response caused by environmental excitation, the accelerometers are mounted on the structure to get the structure’s acceleration response, and then several ap- proaches, such as the combination of natural excitation technique (NExT) and eigensystem realization algorithm (ERA) and the stochastic subspace identification technique (SSI), are used to determine the structure’s modal parameters. However, the accelerometers must be installed on the structure ahead of time, which is costly and inconvenient if the sensors installation is difficult. For a vision-based approach, which does not require installation of sensors, the natural frequencies of the structure can be approximately evaluated by Fourier transform, but it is difficult to quantify the mode shapes, since the extracted dynamic responses by vision-based technique usually have insufficient accuracy. As a result, the critical challenge in vision-based mode shape identification of structures subject to ambient excitation is to improve the noise resistance and robustness in low-level vibration signals." 469 1756 W4319965899.pdf 1 7 separator 0.97470593 ¶ 1756 1758 W4319965899.pdf 1 8 text 0.9954158 "Motion magnification has been proposed [ 13] recently to increase the signal-to-noise ratio (SNR) in low-amplitude vibrations. However, motion magnification (video magnification) technology employed to preprocess the source footage necessitates a significant amount of storage space. A hybrid identification method combining a high-speed camera with accelerometers was proposed [ 14] to increase the estimate accuracy of mode shapes [ 15]. " 1758 2202 W4319965899.pdf 1 9 separator 0.6392652 ¶ 2202 2203 W4319965899.pdf 1 10 text 0.99954456 "Nevertheless, this approach will lose its universality if the structure is not appropriate for mounting accelerometers." 2203 2325 W4319965899.pdf 1 11 separator 0.9746475 ¶ 2325 2327 W4319965899.pdf 1 12 text 0.99970156 "This paper presents a novel signal processing algorithm for the vision-based method to identify mode shapes of structures with small amplitude vibration. Lab-scale experimental tests on a cantilever beam showed that with the proposed signal processing algorithm, the first two mode shapes can be accurately extracted even if the displacement amplitude is as low as 0.01 mm (0.06 pixel) whereas without the proposed signal reconstruction they can only be identified if the displacement amplitude is higher than 0.06 mm (0.3 pixel). The proposed algorithm also performed well for a variety of focal lengths and object distances." 2327 2964 W4319965899.pdf 1 13 separator 0.94136405 ¶ 2964 2966 W4319965899.pdf 1 14 text 0.9996677 "Compared to other motion amplification methods, the suggested approach shows the benefits of a shorter operation time and less storage space by processing the extracted displacement directly rather than applying amplification to the source video to speed up modal identification. The framework of the vision-based dynamic response extraction and modal identification method is summarized as follows. First, the template matching method, in conjunction with subpixel methodologies, is used to extract the displacements at different points on the targeted structure. Then the proposed signal processing algorithm is adopted to reconstruct the displacement and acceleration. Finally, the mode shapes of the targeted structure can be evaluated by NexT-ERA approach." 2966 3739 W4319965899.pdf 1 15 separator 0.9967624 ¶ 3739 3741 W4319965899.pdf 1 16 title 0.99348325 2. Theoretical Background 3741 3767 W4319965899.pdf 1 17 separator 0.98965824 ¶ 3767 3769 W4319965899.pdf 1 18 title 0.9917625 2.1. Dynamic Response Extraction Based on Template Matching at the Subpixel Level 3769 3851 W4319965899.pdf 1 19 separator 0.991873 ¶ 3851 3853 W4319965899.pdf 1 20 text 0.99615616 "Figure 1 shows the illustration of vision-based displacement measurement; the targets should be pre-positioned on the structure, and the position of each target in the source image can be determined by template matching to calculate the time history of displacement of each target." 3853 4141 W4319965899.pdf 1 0 bibliography 0.9737641 32 0 2 W4285576944.pdf 12 1 separator 0.9781233 ¶ 2 4 W4285576944.pdf 12 2 bibliography 0.99812394 Jiménez-Ortiz, Sánchez-Cardona, & Pérez-Pedrogo, Evaluar, 2020, 20(3), 20-33 4 81 W4285576944.pdf 12 3 separator 0.6011783 ¶ 81 83 W4285576944.pdf 12 4 bibliography 0.9974972 "self-sexualization. SAGE Open, 9 (2), 1-14. doi: 10.1177/2158244019848905" 83 160 W4285576944.pdf 12 5 separator 0.96065813 ¶ 160 162 W4285576944.pdf 12 6 bibliography 0.99645424 "IBM Corporation. (2013). SPSS Statistics for Windows (Version 22). [computer software]. Armonk, NY: IBM." 162 273 W4285576944.pdf 12 7 separator 0.97726893 ¶ 273 275 W4285576944.pdf 12 8 bibliography 0.99804765 "Karsay, K., Knoll, J., & Matthes, J. (2017). Sexual - izing media use and self-objectification. Psy- chology of Women Quarterly, 42 (1), 9-28. doi: 10.1177/0361684317743019" 275 455 W4285576944.pdf 12 9 separator 0.9556744 ¶ 455 457 W4285576944.pdf 12 10 bibliography 0.99808985 "Manago, A. M., Ward, L. M., Lemm, K. M., Reed, L., & Seabrook, R. (2014). Facebook involvement, objec - tified body consciousness, body shame, and sexual assertiveness in college women and men. Sex Roles, 72(1-2), 1-14. doi: 10.1007/s11199-014-0441-1" 457 719 W4285576944.pdf 12 11 separator 0.9590603 ¶ 719 721 W4285576944.pdf 12 12 bibliography 0.9980542 "McKinley, N. M., & Hyde, J. S. (1996). The Objectified Body Consciousness Scale: Development and vali - dation. Psychology of Women Quarterly, 20(2), 181- 215. doi: 10.1111/j.1471-6402. 1996.tb00467.x" 721 930 W4285576944.pdf 12 13 separator 0.9646308 ¶ 930 932 W4285576944.pdf 12 14 bibliography 0.9979091 "Moradi, B. (2010). Addressing gender and cultural diversity in body image: Objectification theory as a framework for integrating theories and grounding research. Sex Roles, 63 (1-2), 138-148. doi: 10.1007/s11199-010- 9824-0" 932 1167 W4285576944.pdf 12 15 separator 0.9578483 ¶ 1167 1169 W4285576944.pdf 12 16 bibliography 0.99802536 "Moradi, B., & Huang, Y .-P. (2008). Objectification theory and psychology of women: A decade of advances and future directions. Psycholo - gy of Women Quarterly, 32 (4), 377-398. doi: 10.1111/j.1471-6402.2008.00452.x" 1169 1397 W4285576944.pdf 12 17 separator 0.95580065 ¶ 1397 1399 W4285576944.pdf 12 18 bibliography 0.9980184 "Moradi, B., & Varnes, J. R. (2017). Structure of the Ob - jectified Body Consciousness Scale: Reevaluated 20 years later. Sex Roles, 77 (5-6), 325-337. doi: 10.1007/s11199-016-0731-x" 1399 1590 W4285576944.pdf 12 19 separator 0.9697867 ¶ 1590 1592 W4285576944.pdf 12 20 bibliography 0.9973962 "Moya-Garófano, A., Megías, J. L., Rodríguez-Bailón, R., & Moya, M. (2017). Spanish version of the Objec - tified Body Consciousness Scale (OBCS): Results from two samples of female university students. Revista de Psicología Social, 32 (2), 362-394. doi: 10.1080/02134748.2017.1292700" 1592 1890 W4285576944.pdf 12 21 separator 0.9713664 ¶ 1890 1892 W4285576944.pdf 12 22 bibliography 0.9979097 "Noll, S. M., & Fredrickson, B. L. (1998). A mediational model linking self-objectification, body shame, and disordered eating. Psychology of Women Quarter -ly, 22(4), 623-636. doi: 10.1111/j.1471-6402.1998. tb00181.x" 1892 2117 W4285576944.pdf 12 23 separator 0.959978 ¶ 2118 2120 W4285576944.pdf 12 24 bibliography 0.9923448 "Roberts, T.-A., Calogero, R. M., & Gervais, S. J. (2018). Objectification theory: Continuing contributions to feminist psychology. In C. B. Travis, J. W. White, A. Rutherford, W. S. Williams, S. L. Cook & K. F. Wyche (Eds.), AP A handbooks in psychology®. AP A handbook of the psychology of women: History, theory, and battlegrounds (pp. 249-271). Washing - ton, DC. American Psychological Association. doi: 10.1037/0000059-013" 2120 2572 W4285576944.pdf 12 25 separator 0.96737117 ¶ 2572 2574 W4285576944.pdf 12 26 bibliography 0.9980345 "Satorra, A., & Bentler, P. M. (1994). Correction to test sta - tistics and standard errors in covariance structure analysis. In A. von Eye & C. C. Clogg (Eds.), Latent variables analysis: Applications for developmental research (pp. 399-419). Sage Publications." 2574 2847 W4285576944.pdf 12 27 separator 0.96776474 ¶ 2847 2849 W4285576944.pdf 12 28 bibliography 0.99138445 "Schaefer, L. M., Burke, N. L., Calogero, R. M., Menzel, J. E., Krawczyk, R., & Thompson, J. K. (2018). Self-objectification, body shame, and disordered eating: Testing a core mediational model of objec - tification theory among White, Black, and Hispanic women. Body Image, 24 , 5-12 doi: 10.1016/j.body - im.2017.10.005" 2849 3186 W4285576944.pdf 12 29 separator 0.9739138 ¶ 3186 3188 W4285576944.pdf 12 30 bibliography 0.9980656 "Steer, A., & Tiggemann, M. (2008). The role of self-objec - tification in women’s sexual functioning. Journal of Social and Clinical Psychology, 27 (3), 205-225. doi: 10.1521/jscp.2008.27.3.205" 3188 3390 W4285576944.pdf 12 31 separator 0.96637046 ¶ 3390 3392 W4285576944.pdf 12 32 bibliography 0.99751794 "Szymanski, D. M., Moffitt, L. B., & Carr, E. R. (2010). Sexual objectification of women: Advances to the - ory and research 1ψ7. The Counseling Psychologist, 39(1), 6-38. doi: 10.1177/0011000010378402" 3392 3601 W4285576944.pdf 12 33 separator 0.96500635 ¶ 3601 3603 W4285576944.pdf 12 34 bibliography 0.998069 "Tiggemann, M., & Andrew, R. (2012). Clothes make a dif - ference: The role of self-objectification. Sex Roles, 66(9-10), 646-654. doi: 10.1007/s11199-011-0085-3" 3603 3769 W4285576944.pdf 12 35 separator 0.9620701 ¶ 3769 3771 W4285576944.pdf 12 36 bibliography 0.99804616 "Tiggemann, M., & Kuring, J. K. (2004). The role of body objectification in disordered eating and depressed mood. British Journal of Clinical Psychology, 43 (3), 299-311. doi: 10.1348/0144665031752925" 3771 3980 W4285576944.pdf 12 37 separator 0.97381556 ¶ 3980 3982 W4285576944.pdf 12 38 bibliography 0.99786246 "Veldhuis, J., Alleva, J. M., Bij de Vaate, A. J. D. (Nadia), Keijer, M., & Konijn, E. A. (2020). Me, my selfie, and I: The relations between selfie behaviors, body" 3982 4152 W4285576944.pdf 12 0 paratext 0.967346 "https://doi.org/10.1177/2324709618812196Journal of Investigative Medicine High Impact Case Reports Volume 6: 1–4 © 2018 American Federation for Medical Research DOI: 10.1177/2324709618812196 journals.sagepub.com/home/hic Creative Commons CC BY: This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).Case Report" 0 654 W2900513586.pdf 0 1 separator 0.9954931 ¶ 654 656 W2900513586.pdf 0 2 title 0.96473986 Introduction 656 669 W2900513586.pdf 0 3 separator 0.99365056 ¶ 669 671 W2900513586.pdf 0 4 text 0.9996909 "Macrophage activation syndrome (MAS) is a life-threaten- ing condition. It belongs to the hemophagocytic lymphohis-tiocytosis (HLH) group of diseases, which includes familial HLH and secondary HLH. Secondary HLH is triggered by several causes that disrupt immune homeostasis, which includes infection, drugs, rheumatic disorder, and malig-nancy. HLH is characterized by proliferation and activation of T lymphocytes and macrophages, which causes an exces-sive inflammatory response and hypersecretion of cytokines. Clinically, patients usually present with prolonged fever, pancytopenia, hepatosplenomegaly, liver function abnormal-ities, hyperferritinemia, and coagulopathy." 671 1349 W2900513586.pdf 0 5 separator 0.9948405 ¶ 1349 1351 W2900513586.pdf 0 6 title 0.80917233 1 Systemic lupus 1351 1368 W2900513586.pdf 0 7 text 0.97352564 "¶ erythematosus (SLE) is a systemic autoimmune disorder that involves multiple visceral organs. In adults, MAS is rarely associated with SLE 2 the incidence of MAS associated with SLE is about 0.9% to 4.6%.3,4 In this article, we report a case of MAS that occurred as the first manifestation of SLE." 1369 1677 W2900513586.pdf 0 8 separator 0.99747765 ¶ 1677 1679 W2900513586.pdf 0 9 title 0.9917846 Case Presentation 1679 1697 W2900513586.pdf 0 10 separator 0.9962383 ¶ 1697 1699 W2900513586.pdf 0 11 text 0.9996391 "A previously healthy 26-year-old Caucasian woman was admitted due to high fever with rash for 2 days. The fever and rash started after lamotrigine was started for her bipolar disorder 1 week ago. However, on further questioning, she also had history of alopecia, arthritis, and oral ulcers inter - mittently. Her past medical history was unremarkable for rheumatic disease, severe infections, or immunodeficiency. Her family history was also negative for rheumatic disease. On admission, vital signs were normal except for the tem-perature of 101.5°F. On physical examination, she had dif-fuse erythematous maculopapular non-itchy rashes over her face and chest without mucocutaneous involvement. Since she complained of the rashes after starting the new medica-tion, we initially treated her as an allergic reaction to the new drug with diphenhydramine and methylprednisolone. How-ever, she continued to have fever spikes along with worsening of her rash." 1699 2658 W2900513586.pdf 0 12 separator 0.9901601 ¶ 2658 2660 W2900513586.pdf 0 13 text 0.7693699 "Laboratory results showed white blood cells 1.7 × 10 9/L, absolute neutrophils 1.51 × 103/μL, absolute lymphocytes 0.08 × 103/μL, hemoglobin 10.3 g/dL, platelets 138 000 μL, aspartate transaminase 57 U/L, alanine transaminase 19 U/L, triglycerides level 266 mg/dL, fibrinogen 273 mg/dL, ferritin level 16911 ng/mL (normal = 13-150 ng/mL), and elevated 812196 HICXXX10.1177/2324709618812196Journal of Investigative Medicine High Impact Case Reports" 2660 3122 W2900513586.pdf 0 14 paratext 0.51341903 Po 3122 3124 W2900513586.pdf 0 15 text 0.642689 udel et 3124 3131 W2900513586.pdf 0 16 paratext 0.53330916 al 3131 3134 W2900513586.pdf 0 17 separator 0.6682379 ¶ 3134 3136 W2900513586.pdf 0 18 paratext 0.9708792 case-report 2018 2018 3136 3158 W2900513586.pdf 0 19 separator 0.9521744 ¶ 3158 3160 W2900513586.pdf 0 20 contact 0.9832549 "1State University of New York Upstate Medical University, Syracuse, NY, USA 2Interfaith Medical Center, New York, NY, USA" 3160 3288 W2900513586.pdf 0 21 separator 0.9334536 ¶ 3288 3290 W2900513586.pdf 0 22 paratext 0.973321 "Received July 3, 2018. Revised September 24, 2018. Accepted September 29, 2018." 3290 3373 W2900513586.pdf 0 23 separator 0.9520872 ¶ 3373 3375 W2900513586.pdf 0 24 contact 0.9949496 "Corresponding Author: Pooja Poudel, State University of New York Upstate Medical University, 750 East Adams, Syracuse, NY 13210-2306, USA. Email: poojapoudel112@gmail.com" 3375 3548 W2900513586.pdf 0 25 title 0.92491525 "A Rare Case of Macrophage Activation Syndrome Presenting as the First Manifestation of Systemic Lupus Erythematosus" 3548 3666 W2900513586.pdf 0 26 separator 0.8831506 ¶ 3666 3668 W2900513586.pdf 0 27 contact 0.9962689 Pooja Poudel, MBBS1, Thein Swe, MD2, and Sheetal Rayancha, MD1 3668 3731 W2900513586.pdf 0 28 separator 0.99494106 ¶ 3731 3733 W2900513586.pdf 0 29 title 0.96017694 Abstract 3733 3742 W2900513586.pdf 0 30 separator 0.9959643 ¶ 3742 3744 W2900513586.pdf 0 31 text 0.99962056 Macrophage activation syndrome (MAS) itself is a rare, potentially life-threatening complication of a rheumatic disease, mostly seen in juvenile idiopathic arthritis. It infrequently occurs in systemic lupus erythematosus (SLE), and it is extremely rare to be the first presentation of SLE. In a study of 511 patients with SLE, 7 cases (1.4%) of MAS were identified. In all the cases, MAS was simultaneous to the presentation of SLE in this article, we report a case of a patient with MAS who presented with fever, rash, and high ferritin level up to 16911 ng/mL. A high degree of suspicion is required that high fever and rash can be clues to MAS. Early diagnosis is necessary since mortality rates remain high for untreated cases. 3744 4477 W2900513586.pdf 0 32 separator 0.9968056 ¶ 4477 4479 W2900513586.pdf 0 33 title 0.9143554 Keywords 4479 4488 W2900513586.pdf 0 34 separator 0.9970437 ¶ 4488 4490 W2900513586.pdf 0 35 text 0.9771328 MAS, SLE 4490 4499 W2900513586.pdf 0 0 paratext 0.98813957 Int. J. Mol. Sci. 2022 ,23, 12988 8 of 18 0 41 W4307358136.pdf 7 1 separator 0.8088139 ¶ 41 43 W4307358136.pdf 7 2 paratext 0.98611987 Int. J. Mol. Sci. 2022, 23, 12988 8 of 19 43 86 W4307358136.pdf 7 3 separator 0.97270757 ¶ ¶ 87 93 W4307358136.pdf 7 4 text 0.99877095 "(Figure 5). The rise period was found to be 15 min for Bolokhovo and 20 for Novomos ‐ kovsk; the difference may stem from a longer maturation time of Novomoskovsk, which is consistent with a larger burst size." 94 314 W4307358136.pdf 7 5 separator 0.98038965 ¶ ¶ 315 321 W4307358136.pdf 7 6 caption 0.99496996 "Figure 6. Growth dynamics of Novomoskovsk and Bolokhovo on B. pumilus AVS‐01. (a) Adsorption assay, (b) one‐step growth curve assay." 321 461 W4307358136.pdf 7 7 separator 0.99598384 ¶ 462 464 W4307358136.pdf 7 8 title 0.994022 2.6. Thermal and pH Stability of Phages 464 504 W4307358136.pdf 7 9 separator 0.99264437 ¶ 505 507 W4307358136.pdf 7 10 text 0.99970716 "Phage stability was assessed at different temperatures and pH values. Both phages remained viable in a broad range of temperatures and pH values. Bolokhovo remained stable (109 PFU/mL) at pH values ranging from 4 to 11, and at temperatures ranging from 4 °C to 50 °C (Figure 7a,c); whereas at 60 °C, the phage titer dropped significantly (106 PFU/mL). Novomoskovsk remained stable (109 PFU/mL) at temperatures ranging from 4 °C to 60 °C and pH values from 4 to 10 (Figure 7b,d)." 507 1017 W4307358136.pdf 7 11 separator 0.90153605 ¶ ¶ 1018 1025 W4307358136.pdf 7 12 caption 0.9953269 "Figure 7. Thermal and pH stability of the Bolokhovo and Novomoskovsk phages. (a,b) Thermal stability diagrams; (c,d) pH stability diagrams. The results are expressed as the mean ± standard deviation for three replicates." 1025 1259 W4307358136.pdf 7 13 separator 0.9920962 ¶ 1261 1263 W4307358136.pdf 7 14 paratext 0.98191 Int. J. Mol. Sci. 2022, 23, 12988 8 of 19 1263 1306 W4307358136.pdf 7 15 separator 0.9699638 ¶ ¶ 1307 1313 W4307358136.pdf 7 16 text 0.9992131 "(Figure 5). The rise period was found to be 15 min for Bolokhovo and 20 for Novomos ‐ kovsk; the difference may stem from a longer maturation time of Novomoskovsk, which is consistent with a larger burst size." 1314 1534 W4307358136.pdf 7 17 separator 0.9808841 ¶ ¶ 1535 1541 W4307358136.pdf 7 18 caption 0.9952441 "Figure 6. Growth dynamics of Novomoskovsk and Bolokhovo on B. pumilus AVS‐01. (a) Adsorption assay, (b) one‐step growth curve assay." 1541 1681 W4307358136.pdf 7 19 separator 0.9959162 ¶ 1682 1684 W4307358136.pdf 7 20 title 0.99414325 2.6. Thermal and pH Stability of Phages 1684 1724 W4307358136.pdf 7 21 separator 0.9939718 ¶ 1725 1727 W4307358136.pdf 7 22 text 0.9997257 "Phage stability was assessed at different temperatures and pH values. Both phages remained viable in a broad range of temperatures and pH values. Bolokhovo remained stable (109 PFU/mL) at pH values ranging from 4 to 11, and at temperatures ranging from 4 °C to 50 °C (Figure 7a,c); whereas at 60 °C, the phage titer dropped significantly (106 PFU/mL). Novomoskovsk remained stable (109 PFU/mL) at temperatures ranging from 4 °C to 60 °C and pH values from 4 to 10 (Figure 7b,d)." 1727 2237 W4307358136.pdf 7 23 separator 0.9106513 ¶ ¶ 2238 2245 W4307358136.pdf 7 24 caption 0.99577904 "Figure 7. Thermal and pH stability of the Bolokhovo and Novomoskovsk phages. (a,b) Thermal stability diagrams; (c,d) pH stability diagrams. The results are expressed as the mean ± standard deviation for three replicates." 2245 2479 W4307358136.pdf 7 25 separator 0.9868351 ¶ 2481 2483 W4307358136.pdf 7 26 caption 0.9956438 "Figure 7. Thermal and pH stability of the Bolokhovo and Novomoskovsk phages. ( a,b) Thermal stability diagrams; ( c,d) pH stability diagrams. The results are expressed as the mean standard deviation for three replicates." 2483 2709 W4307358136.pdf 7 27 separator 0.9960737 ¶ 2709 2711 W4307358136.pdf 7 28 title 0.9941627 2.7. Divergence and Domain Organisation of Novomoskovsk and Bolokhovo Depolymerases 2711 2795 W4307358136.pdf 7 29 separator 0.9951019 ¶ 2795 2797 W4307358136.pdf 7 30 text 0.9994768 "Negative colonies of Novomoskovsk and Bolokhovo are surrounded by halos (Figure 1a). Such halos may occur because of the degradation of bacterial mucus mediated by soluble forms of phage depolymerases [ 47–49]. Due to a smaller size, the enzymes diffuse in soft agar faster than bacteriophages; therefore, they can digest bacterial cap- sules that have not been affected by phage endolysins or tail depolymerases [ 31]. Both Novomoskovsk and Bolokhovo encode depolymerases of the Pectin_lyas_fold superfamily (InterPro code: IPR012334) (gp28 and gp31 in the Bolokhovo and Novomoskovsk genomes, respectively) (Supplementary Figures S1 and S2)." 2797 3454 W4307358136.pdf 7 31 separator 0.95364815 ¶ 3454 3456 W4307358136.pdf 7 32 text 0.9996725 "Gp28 contains a Pectate_lyase_SF_prot domain (IPR024535) in its N-terminal part and a Beta_helix domain (IPR039448) at the C-terminus, while Gp31 only has a Beta helix domain in its C-terminal region. Pectinlyase-like sequences and beta-helices are typical for phage depolymerases described in other studies [ 30,31,47,50,51]. A BLASTp alignment of the putative depolymerases of Bolokhovo and Novomoskovsk revealed that the proteins are 29.73% identical to each other, the coverage being 99%. An HHpred analysis revealed that both Gp28 and Gp31 have homologs among the domains and proteins of the Pectinlyase- like superfamily (SCOPe ID: b.80.1) [ 52]. For instance, HHpred probability values of 99% were obtained in the alignments of both proteins with the rhamnogalacturonase A of Aspergillus aculeatus (SCOPe ID: d1rmga_), suggesting that Gp28 and Gp31, though highly divergent in sequence, are structurally and functionally homologous." 3456 4416 W4307358136.pdf 7 33 separator 0.9827342 ¶ 4416 4418 W4307358136.pdf 7 34 text 0.99305296 "The Maximum Likelihood phylogram inferred from the multiple alignment of Gp28, Gp31 and different endolysins and depolymerases of the members of Andromedavirus is shown in Figure 8. Significantly diverged from one another, Gp28 and Gp31 fall into different clades. The two proteins being so divergent, it is reasonable to expect them to differ considerably in their key characteristics, such as affinity to bacterial glycocalyx." 4418 4853 W4307358136.pdf 7 0 paratext 0.96793973 Page 14 of 14 Stangler et al. Fluids and Barriers of the CNS (2021) 18:52 0 83 W3215316879.pdf 13 1 separator 0.7461082 ¶ • ¶ 84 90 W3215316879.pdf 13 2 text 0.69472 "fast, convenient online submission • thorough peer review by experienced researchers in your field • rapid publication on acceptance • support for research data, including large and complex data types • gold Open Access which fosters wider collaboration and increased citations maximum visibility for your research: over 100M website views per year •" 91 470 W3215316879.pdf 13 3 separator 0.588347 ¶ 470 472 W3215316879.pdf 13 4 paratext 0.6478785 At BMC, research is always in progress. 474 514 W3215316879.pdf 13 5 separator 0.58224225 ¶ 514 516 W3215316879.pdf 13 6 paratext 0.7094598 Learn more biomedcentral.com/submissionsReady 516 562 W3215316879.pdf 13 7 title 0.7593853 to submit y our researc h 562 588 W3215316879.pdf 13 8 paratext 0.3864734 Ready 588 594 W3215316879.pdf 13 9 text 0.4838131 to submit y our researc h ? Choose BMC and benefit fr om: ? Choose BMC and benefit fr om: 594 687 W3215316879.pdf 13 10 separator 0.99133337 ¶ 688 690 W3215316879.pdf 13 11 bibliography 0.9972256 "110. Kanamori K. Faster flux of neurotransmitter glutamate during seizure— evidence from 13 C-enrichment of extracellular glutamate in kainate rat model. PLoS One. 2017;12(4):e0174845." 691 881 W3215316879.pdf 13 12 separator 0.95897985 ¶ 881 883 W3215316879.pdf 13 13 bibliography 0.99715847 "111. Morales-Villagran A, Pardo-Pena K, Medina-Ceja L, Lopez-Perez S. A microdialysis and enzymatic reactor sensing procedure for the simultaneous registration of online glutamate measurements at high temporal resolution during epileptiform activity. J Neurochem. 2016;139(5):886–96." 884 1180 W3215316879.pdf 13 14 separator 0.96896166 ¶ 1180 1182 W3215316879.pdf 13 15 bibliography 0.99799323 "112. Soukupova M, Binaschi A, Falcicchia C, Palma E, Roncon P , Zucchini S, et al. Increased extracellular levels of glutamate in the hippocampus of chronically epileptic rats. Neuroscience. 2015;301:246–53." 1183 1397 W3215316879.pdf 13 16 separator 0.95440924 ¶ 1397 1399 W3215316879.pdf 13 17 bibliography 0.9974623 "113. Konno D, Nakayama R, Tsunoda M, Funatsu T, Ikegaya Y, Sasaki T. Collection of biochemical samples with brain-wide electrophysi- ological recordings from a freely moving rodent. J Pharmacol Sci. 2019;139(4):346–51." 1400 1627 W3215316879.pdf 13 18 separator 0.9622778 ¶ 1627 1629 W3215316879.pdf 13 19 bibliography 0.9979719 "114. Bourdon AK, Spano GM, Marshall W, Bellesi M, Tononi G, Serra PA, et al. Metabolomic analysis of mouse prefrontal cortex reveals upregulated analytes during wakefulness compared to sleep. Sci Rep. 2018;8(1):11225." 1630 1857 W3215316879.pdf 13 20 separator 0.9516558 ¶ 1857 1859 W3215316879.pdf 13 21 bibliography 0.9979941 "115. Hiller A, Loeffler S, Haupt C, Litza M, Hofmann U, Moser A. Electrical high frequency stimulation of the caudate nucleus induces local GABA outflow in freely moving rats. J Neurosci Methods. 2007;159(2):286–90." 1860 2082 W3215316879.pdf 13 22 separator 0.94943 ¶ 2082 2084 W3215316879.pdf 13 23 bibliography 0.9979941 "116. Tamano H, Nishio R, Shakushi Y, Sasaki M, Koike Y, Osawa M, et al. In vitro and in vivo physiology of low nanomolar concentrations of Zn(2+) in artificial cerebrospinal fluid. Sci Rep. 2017;7:42897." 2085 2295 W3215316879.pdf 13 24 separator 0.867622 ¶ 2295 2297 W3215316879.pdf 13 25 bibliography 0.99789226 "117. Tamano H, Nishio R, Takeda A. Involvement of intracellular Zn(2+) signaling in LTP at perforant pathway-CA1 pyramidal cell synapse. Hip - pocampus. 2017;27(7):777–83." 2298 2475 W3215316879.pdf 13 26 separator 0.9238951 ¶ 2475 2477 W3215316879.pdf 13 27 bibliography 0.9978083 "118. Potschka H, Baltes S, Fedrowitz M, Loscher W. Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats. Neuropharmacology. 2011;61(5-6):909–17." 2478 2675 W3215316879.pdf 13 28 separator 0.94648063 ¶ 2675 2677 W3215316879.pdf 13 29 bibliography 0.99765563 "119. Varatharajan R, Joseph K, Neto SC, Hofmann UG, Moser A, Tronnier V. Electrical high frequency stimulation modulates GABAergic activ- ity in the nucleus accumbens of freely moving rats. Neurochem Int. 2015;90:255–60." 2678 2907 W3215316879.pdf 13 30 separator 0.9547498 ¶ 2907 2909 W3215316879.pdf 13 31 bibliography 0.9979565 "120. Schumacher A, Haegele M, Spyth J, Moser A. Electrical high frequency stimulation of the nucleus accumbens shell does not modulate depressive-like behavior in rats. Behav Brain Res. 2020;378:112277." 2910 3119 W3215316879.pdf 13 32 separator 0.9431681 ¶ 3119 3121 W3215316879.pdf 13 33 bibliography 0.9978483 "121. Soukupova M, Falcicchia C, Lovisari F, Ingusci S, Barbieri M, Zucchini S, et al. Microdialysis of excitatory amino acids during eeg recordings in freely moving rats. J Vis Exp. 2018(141)." 3122 3321 W3215316879.pdf 13 34 separator 0.89137506 ¶ 3321 3323 W3215316879.pdf 13 35 bibliography 0.9978765 "122. During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet. 1993;341(8861):1607–10." 3324 3480 W3215316879.pdf 13 36 separator 0.9299434 ¶ 3480 3482 W3215316879.pdf 13 37 bibliography 0.9977661 "123. Fried I, Wilson CL, Maidment NT, Engel J, Behnke E, Fields TA, et al. Cerebral microdialysis combined with single-neuron and electro - encephalographic recording in neurosurgical patients. J Neurosurg. 1999;91(4):697–705." 3483 3718 W3215316879.pdf 13 38 separator 0.95444953 ¶ 3718 3720 W3215316879.pdf 13 39 bibliography 0.9977454 "124. Vezzani A, Ungerstedt U, French ED, Schwarcz R. In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissocia- tion between neurochemical changes and seizures. J Neurochem. 1985;45(2):335–44." 3721 4017 W3215316879.pdf 13 40 separator 0.9628471 ¶ 4017 4019 W3215316879.pdf 13 41 bibliography 0.9979313 "125. John R, John MJ. Evaluation of the microdialysis electrode concept as a generic biosensing technology. Electroanalysis. 1998;10(16):1125–9." 4020 4168 W3215316879.pdf 13 42 separator 0.94457537 ¶ 4168 4170 W3215316879.pdf 13 43 bibliography 0.9977802 "126. Walker MC, Galley PT, Errington ML, Shorvon SD, Jefferys JG. Ascor - bate and glutamate release in the rat hippocampus after per - forant path stimulation: a “dialysis electrode” study. J Neurochem. 1995;65(2):725–31." 4171 4401 W3215316879.pdf 13 44 separator 0.97175527 ¶ 4401 4403 W3215316879.pdf 13 45 bibliography 0.99793637 "127. Cavus I, Romanyshyn JC, Kennard JT, Farooque P , Williamson A, Eid T, et al. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: microdialysis study of 79 patients at the yale epilepsy surgery program. Ann Neurol. 2016;80(1):35–45." 4404 4680 W3215316879.pdf 13 46 separator 0.97024053 ¶ 4680 4682 W3215316879.pdf 13 47 bibliography 0.99814165 "128. Mishra P , Lehmann J, Nair N. Inventors microdialysis probes and meth- ods of use patent 5,441,481. 1994." 4683 4796 W3215316879.pdf 13 48 separator 0.83916056 ¶ 4796 4798 W3215316879.pdf 13 49 bibliography 0.99776655 "129. Kucharczyk J, Gillies GT. Inventors multi-probe system patent 6,626,902. 2003." 4799 4887 W3215316879.pdf 13 50 separator 0.9698777 ¶ 4887 4889 W3215316879.pdf 13 51 bibliography 0.99765146 "130. Engström ER, Hillered L, Flink R, Kihlström L, Lindquist C, Nie JX, et al. Extracellular amino acid levels measured with intracerebral microdialy- sis in the model of posttraumatic epilepsy induced by intracortical iron injection. Epilepsy Res. 2001;43(2):135–44. 131. Amberg G, Lindefors N. Intracerebral microdialysis: II. Math- ematical studies of diffusion kinetics. J Pharmacolog Methods. 1989;22(3):157–83." 4890 5321 W3215316879.pdf 13 52 separator 0.96222603 ¶ 5321 5323 W3215316879.pdf 13 53 bibliography 0.9978926 "132. Lopes da Silva F, Pijn JP , Boeijinga P . Interdependence of EEG signals: linear vs. nonlinear associations and the significance of time delays and phase shifts. Brain Topography. 1989;2(1):9–18." 5324 5531 W3215316879.pdf 13 54 separator 0.9571632 ¶ 5531 5533 W3215316879.pdf 13 55 bibliography 0.99773884 "133. Höller Y, Nardone R. Chapter Six - Quantitative EEG biomarkers for epi- lepsy and their relation to chemical biomarkers. In: Makowski GS, editor. 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Role of LC_GidA in L. capsiciFrontiers in Microbiology | www.frontiersin.org 3 March 2022 | Volume 13 | Article 840792 0 133 W4221015550.pdf 2 1 title 0.43860343 de 133 135 W4221015550.pdf 2 2 text 0.99123913 "rivative strains were grown at 28 °C in nutrient broth (NB) medium or on NA (NB with 1.5% agar) medium. Transformants from the first crossover for the LC_GidA knockout were cultured on NBN (NB without 1% sucrose) or NAN (NBN with 1.5% agar) medium. Transformants bearing the second crossover were plated on NAS (NAN plus 10% sucrose) medium ( Zou et al., 2011 ). All bacterial strains were incubated at 28°C. Escherichia coli strains were cultured in Luria-Bertani (LB) or LB plus 1.5% agar plates at 37 °C. When necessary, the media were supplemented with the antibiotic ampicillin (Amp, 50 μg/ml), kanamycin (Km, 50 μg/ml), or gentamicin (Gm, 50 μg/ml), depending on the strains used." 135 860 W4221015550.pdf 2 3 separator 0.99549365 ¶ 860 862 W4221015550.pdf 2 4 title 0.9933554 Construction of the LC_GidA Deletion 862 900 W4221015550.pdf 2 5 separator 0.95764625 ¶ 901 903 W4221015550.pdf 2 6 title 0.989192 Mutant and Its Complemented Strain 903 938 W4221015550.pdf 2 7 separator 0.9898119 ¶ 938 940 W4221015550.pdf 2 8 text 0.99966365 "The LC_GidA mutant was generated from the wild-type X2-3 strain by allelic homologous recombination. Briefly, two LC_GidA flanking regions were amplified by PCR using the primer pairs up F/R and down F/R ( Table 1 ). The upstream and downstream PCR products were digested with Bam HI and HindIII, respectively. The digested fragments were ligated into the suicide vector pKMS1 ( Table 1 ) to obtain the recombinant plasmid pKMS1-AB ( Zou et al., 2011 ). The plasmid was transformed into X2-3 by electroporation. The LC_GidA mutant MT16 was obtained after two recombination events and confirmed by PCR and sequencing of the PCR products." 940 1613 W4221015550.pdf 2 9 separator 0.9049182 ¶ 1613 1615 W4221015550.pdf 2 10 text 0.9996628 "The fragment harboring the intact LC_GidA gene, which was amplified by PCR using the primers gidA F and gidA R (Table 1 ), was cloned into the expression vector pBBR1-MCS5 (Table 1 ) at the EcoRI and Bam HI site, resulting in the recombinant plasmid pBBR1- gidA , and then pBBR1- gidA was transformed into the mutant MT16 by electroporation (1.8 KV , 200 Ω, and 25 μF). The complemented mutant strain Com-16 was selected on NA plates with gentamycin ( Kovach et al., 1994 )." 1615 2117 W4221015550.pdf 2 11 separator 0.99687994 ¶ 2117 2119 W4221015550.pdf 2 12 title 0.9935794 Growth Curve Determination 2119 2146 W4221015550.pdf 2 13 separator 0.99482626 ¶ 2146 2148 W4221015550.pdf 2 14 text 0.9937766 "The X2-3, MT16, and Com-16 strains were grown for 24 h at 28°C in NA medium and then inoculated into NB medium to OD 600 = 1.0. The cultures were diluted 1:100 into NB medium. The strains were incubated at 28 °C for 48 h with shaking at 180 rpm, and bacterial growth was examined every 4 h (Rehl et al., 2013 )." 2148 2479 W4221015550.pdf 2 15 separator 0.99662316 ¶ 2479 2481 W4221015550.pdf 2 16 title 0.99206996 Motility Assay 2481 2496 W4221015550.pdf 2 17 separator 0.9933759 ¶ 2496 2498 W4221015550.pdf 2 18 text 0.99973524 "The motility assay was performed as previously described (Rashid and Kornberg, 2000 ; Tomada et al., 2016 ). To test twitching motility, bacteria were grown for 24 h in NA medium at 28°C, and 3 μl of the bacterial cultures at a normalized OD 600 were added to NYGB medium (0.6% agar) plates. The diameters of the areas occupied by the bacterial cells were measured after 3 days." 2498 2899 W4221015550.pdf 2 19 separator 0.9968542 ¶ 2899 2901 W4221015550.pdf 2 20 title 0.9929078 Biofilm Formation Assay 2901 2925 W4221015550.pdf 2 21 separator 0.99142975 ¶ 2925 2927 W4221015550.pdf 2 22 text 0.9997154 "The crystal violet technique was used to analyze the attachment of the different strains to an abiotic surface. The X2-3, MT16, and Com-16 strains were cultured in NB medium and adjusted to OD 600 = 1. The cultures were diluted 1:100 into a glass tube containing 10 ml of NB medium supplemented with 1% sucrose or glucose. Then, the glass tubes were incubated at 28 °C for 3 days with shaking at 180 rpm. The growth medium was removed, and the tubes were washed three times with sterile distilled water. Then, the glass tubes were stained with a 0.2% crystal violet solution for 10 min. The unbound crystal violet was removed, and the tubes were washed three times with sterile distilled water. Crystal violet was extracted with absolute ethanol, and the absorbance was measured at 575 nm ( Zhang et al., 2018 )." 2927 3781 W4221015550.pdf 2 23 separator 0.9963283 ¶ 3781 3783 W4221015550.pdf 2 24 title 0.99267995 Pellicle Formation 3783 3802 W4221015550.pdf 2 25 separator 0.9933163 ¶ 3802 3804 W4221015550.pdf 2 26 text 0.9996995 "All Lysobacter strains obtained throughout the study were tested for their ability to produce biofilms, which were visualized as floating pellicle at the air–broth interface that completely blocked the surface of the culture and could not be dispersed by shaking. The X2-3, MT16, and Com-16 strains were grown in glass test tubes containing NB medium (with 1% sucrose or 1% glucose) at 28 °C for 5 days without shaking ( Latasa et al., 2012 )." 3804 4273 W4221015550.pdf 2 27 separator 0.99693024 ¶ 4273 4275 W4221015550.pdf 2 28 title 0.9932159 Root Colonization Assay 4275 4299 W4221015550.pdf 2 29 separator 0.9945531 ¶ 4299 4301 W4221015550.pdf 2 30 text 0.9996238 "Seven-day-old plants were collected, and the roots were cut into 1.5 cm segments. Fragments of uniform shape and size were placed into 96-well microtiter plate. Two hundred microliters of bacterial culture with an OD 600 = 1.0 was added to the wells, and the plates were incubated at 28 °C for 3 days. After the incubation period, the roots were removed from the cultures, washed with sterile water, and then added to 1 ml sterile water." 4301 4760 W4221015550.pdf 2 31 separator 0.52552426 ¶ 4761 4763 W4221015550.pdf 2 32 text 0.99957865 "The bacteria on the root surface were removed and dispersed in sterile water by shaking. One hundred microliters of the dispersed preparation was plated on NA agar and counted after 5 days ( Tariq et al., 2014 )." 4763 4987 W4221015550.pdf 2 33 separator 0.8934274 ¶ 4987 4989 W4221015550.pdf 2 34 text 0.9995093 "The plasmid pBBR1- gfp was transformed into the X2-3, MT16, and Com-16 strains by electroporation, and the transformants were selected on NA plates with gentamycin." 4989 5160 W4221015550.pdf 2 35 separator 0.8937385 ¶ 5161 5163 W4221015550.pdf 2 36 text 0.9995879 "The treatment was the same as above. To view the colonization of L. capsici X2-3- gfp, MT16- gfp, and Com-16- gfp on the root surfaces, the roots were observed using a confocal laser scanning microscope system (Zeiss LSM 800, Carl Zeiss AG, Jena, Germany) with an excitation wavelength of 488 nm. Images of at least 12 roots were obtained for each treatment ( Liu et al., 2020 )." 5163 5564 W4221015550.pdf 2 37 separator 0.9968971 ¶ 5564 5566 W4221015550.pdf 2 38 title 0.99325997 Stress Tolerance Assays 5566 5590 W4221015550.pdf 2 39 separator 0.9949405 ¶ 5590 5592 W4221015550.pdf 2 40 text 0.99947184 "The bacterial strains were diluted 1:100 into NB medium, and experiments were conducted to test the OD 600 under five environmental stresses. Stress treatments were applied as follows: for UV radiation, the cells were exposed to shortwave UV radiation (254 nm in a biological safety cabinet) at a distance of 60 cm for 45 min. For salt stress, NaCl was added to the bacterial cultures at final concentrations of 0.15, 0.25, and 0.35 mol/L ( Li et al., 2014 ). For temperature stress, the cultures were incubated at 37 and 42 °C with shaking at 180 rpm." 5592 6173 W4221015550.pdf 2 41 separator 0.86592984 ¶ 6174 6176 W4221015550.pdf 2 42 text 0.99910796 Resistance against H 2O2 was determined as described previously 6176 6240 W4221015550.pdf 2 0 paratext 0.9693011 "Jurnal Kajian Matematika dan Aplikasinya Vol. 2 No. 2 Tahun 2021 Pemodelani Klaim Asuransi ... Azizah 9" 0 104 W4317825069.pdf 2 1 text 0.999743 Dalam kerangka analisis Bayesian, parameter diperlakukan sebagai variabel acak. Keacakan parameter bukan berasal dari hasil suatu eksperimen yang berbeda-beda. Keacakan parameter terkait dengan distribusi peluang subyektif yang menggambarkan pengetahuan seseorang tentang parameter tersebut. Hal ini berbeda dengan konsep parameter yang nilainya tetap didalam teori statistik klasik sehingga parameter tidak memiliki distribusi peluang, atau dapat dikatakan parameter memiliki suatu nilai pasti tetapi belum diketahui (klugman dkk, 2004). 104 643 W4317825069.pdf 2 2 title 0.9913375 Simulasi Markov Chain Monte Carlo 645 679 W4317825069.pdf 2 3 text 0.9997775 Suatu proses stokastik memiliki sifat Markov, jika distribusi peubah acak X#-& bersyarat pada X(,X&,X),....X# adalah sama dengan distribusi X#-&bersyarat pada X# saja. Suatu proses dengan sifat Markov tersebut dinamakan proses Markov. Jika ruang keadaan pada proses markov tersebut terhitung, maka proses Markov tersebut dapat dinyatakan sebagai rantai Markov. Markov Chain Monte Carlo adalah suatu metode untuk membangkitkan variable acak yang didasarkan pada rantai markov. Metode ini berkaitan dengan estimasi parameter pada inferensi Bayesian. Konsep utama dalam MCMC adalah membuat sampel pendekatan dari distribusi posterior parameter, dengan membangkitkan sebuah rantai Markov yang memiliki distribusi limit mendekati distribusi posterior parameter (Meyers, 2015). Dengan MCMC akan diperoleh suatu barisan sampel acak yang berkorelasi, yakni nilai ke-j dari barisan Uj disampling dari suatu distribusi peluang yang bergantung pada nilai sebelumnya. Distribusi eksak dari (Uj) umumnya tidak diketahui, namun distribusi pada setiap iterasi dalam barisan nilai sampel tersebut akan konvergen pada distribusi yang sesungguhnya untuk nilai t yang cukup besar. Oleh karena itu, jika ukuran sampel yang diperbaharui cukup besar maka kelompok terakhir dari nilai yang disampling dalam barisan tersebut akan mendekati sebuah sampel yang berasal dari distribusi yang diinginkan. Gibbs Sampling adalah salah satu algoritma yang terdapat dalam simulasi MCMC. Konsep utama dalam Gibbs sampling adalah menemukan bentuk distribusi bersyarat univariat dimana dalam distribusi tersebut memuat semua variable random dengan satu variabel yang akan ditentukan nilainya. Gibbs sampling memerlukan distribusi bersyarat penuh (full conditional distribution) dari tiap- tiap variabel. Pada Gibbs sampling semua simulasi adalah univariat dan semua sampel hasil simulasi diterima. Gibar sampling bisa diterapkan apabila distribusi probabilitas bersama (joint probability distribution) tidak diketahui secara eksplisit, tetapi distribusi bersyarat penuh (full conditional distribution) dari tiap-tiap variabel diketahui. 679 2800 W4317825069.pdf 2 4 title 0.98636276 HASIL DAN PEMBAHASAN 2801 2822 W4317825069.pdf 2 5 text 0.998829 Data yang digunakan dalam penelitian ini adalah data banyak klaim pada asuransi kompensasi tenaga kerja. Data dibagi dalam tiga grup polis dan lima tahun polis. 2823 2984 W4317825069.pdf 2 6 table 0.96901935 Tabel 1. Data Simulasi Grup 1 Grup 2 Grup 3 Tahun Gaji (dalam puluhan ribu) Banyak Klaim Gaji (dalam puluhan ribu) Banyak Klaim Gaji (dalam puluhan ribu) Banyak Klaim 1 269 9 265 7 2 315 7 255 3 135 7 3 275 6 230 3 125 2 4 320 13 285 7 115 3 5 ? ? 275 ? 105 ? 2986 3252 W4317825069.pdf 2 0 text 0.9977046 "Stage-strati fied gametocyte populations were produced here at low cost from a single parasite line and, in contrast to previousprotocols, required minimal manipulation and no additional purification or enrichment steps. Our gametocyte populations were viable as measured with live-dead staining ( Figure 2C ) without any detectable morphological abnormalities.Additionally, mature gametoc ytes produced in this manner were fully functional and able to produce high numbers ofexflagellating male gametes (15 –20 ex flagellation centers per field, 16 fields counted, average of 184.8 ± 56.7 total exflagellation centers per experiment; Figure 2D ), comparable to previous work (13 –50 ex flagellation centers per field) ( Delves et al., 2013 )." 0 752 W4283747106.pdf 4 1 separator 0.99422324 ¶ 752 754 W4283747106.pdf 4 2 title 0.98902684 "Evaluating Gametocytocidal Action on Different Stages of Gametocytes" 754 825 W4283747106.pdf 4 3 separator 0.98391354 ¶ 825 827 W4283747106.pdf 4 4 text 0.99932975 "T h ei m m a t u r ea n dm a t u r eg a m e tocyte populations produced a b o v ew e r es u b s e q u e n t l yu s e dt o evaluate gametocytocidal action of compounds by detecting differences in luciferasesignal after a 48 h incubation period. This signal remaineddetectable in the NF54- Pfs1 6 - G F P - l u cl i n eu s e dt op r o d u c et h e different stages of gametocytes for more than 10 generations (Figure S3 ). Luciferase expression could be detected throughout gametocytogenesis ( Figure 3A )b u tw a s expectedly higher in immatu re gametocytes compared to mature gametocytes, as this is associated with Pfs16 promotor activity that is higher in the immature stages but still active inmature stages ( Bruce et al., 1994 ;Van Biljon et al., 2019 ). For both the immature and mature gametocytes, a linearrelationship between gametocyte numbers and luciferase expression was present ( R 2[immature] = 0.9991 and R2 [mature] = 0.9927; Figures 3B, C ) with sensitive detection of signal in as little as ~3,000 gametocytes per well (in a 96-well format) for both immature and mat ure gametocytes. Saturation in the luciferase readout could not be observed at even thehighest cell count tested (15 × 10 3immature gametocytes and ~50 × 103mature gametocytes per well), similar to previous reports with luciferase expression ( D'alessandro et al., 2016 )." 827 2222 W4283747106.pdf 4 5 separator 0.9806528 ¶ 2222 2224 W4283747106.pdf 4 6 text 0.9973552 "Overall assay performance indic ated high reproducibility with Z′-factors of 0.83 ± 0.02 (immature gametocyte assay; n = 81) and 0.84 ± 0.02 (mature gametocyte assay, n = 50) routinelyobtained ( Figures 3D, E )." 2224 2440 W4283747106.pdf 4 7 separator 0.96592957 ¶ 2440 2442 W4283747106.pdf 4 8 text 0.99762833 "To benchmark and validate the use of the stage-strati fied gametocytes produced in gametocytocidal assays, a set of 12known antimalarial compounds were evaluated against both immature and mature gametocytes and compared to published data ( Table S1 ). The gametocytocidal activity of the compounds against our immature gametocyte population strongly correlatedwith that previously observed for both stage II (Pearson R 2= 0.98) and stage III gametocytes (Pearson R2= 0.82; Figure 4A ) (Plouffe et al., 2016 ) supporting the prevalence of stage II/III gametocytes in our immature gametocyte population and the absence of stage IV gametocytes (Pearson R2= 0.48 with stage IV gametocytocidal action as reported ( Plouffe et al., 2016 ))." 2442 3196 W4283747106.pdf 4 9 separator 0.93887496 ¶ 3196 3198 W4283747106.pdf 4 10 text 0.9992529 "Moreover, the gametocytocidal action of the compoundsagainst immature gametocytes correlated weakly (Pearson R 2= 0.55; Figure 4B ) with their activity against ABS parasites." 3198 3377 W4283747106.pdf 4 11 separator 0.83330786 ¶ 3377 3379 W4283747106.pdf 4 12 text 0.98226243 "Particularly, pyrimethamine and atovaquone that are potent ABS actives have no (>5,000 nM) activity against immature AB" 3379 3503 W4283747106.pdf 4 13 separator 0.8633089 ¶ 3503 3505 W4283747106.pdf 4 14 text 0.85626256 D 3505 3507 W4283747106.pdf 4 15 separator 0.690948 ¶ 3507 3509 W4283747106.pdf 4 16 text 0.6778126 C 3509 3511 W4283747106.pdf 4 17 separator 0.9880153 ¶ 3511 3513 W4283747106.pdf 4 18 caption 0.9951112 "FIGURE 2 | Morphological stage distribution and viability con firmation of immature and mature gametocytes. Quanti fication of the stage distribution of (A)immature gametocytes indicated at >80% enrichment to stage II/III gametocytes and (B)>90% stage V mature gametocytes on the day of assay. N > 30 individual exp, ~500 red blood cell counted/exp ± S.E. (C)Hydroethidine-stained confocal images con firmed the viability of untreated gametocytes and the “dead ”phenotype observed following DHA treatment on both immature and mature gametocytes (at 1× IC 50of 20 nM and 5 μM, respectively). Magni fication, ×1,000. (D)Viability of mature gametocytes was further evaluated by con firming male ex flagellation before initiating any assays (N > 25, ± S.E.). MB, methylene blue (10 μM) treated gametocytes; UT, untreated gametocytes." 3513 4347 W4283747106.pdf 4 19 paratext 0.4457702 Reader 4347 4353 W4283747106.pdf 4 20 caption 0.6231703 et al. 4353 4360 W4283747106.pdf 4 21 paratext 0.9344058 Malaria Gametocyte Drug Screening 4360 4394 W4283747106.pdf 4 22 separator 0.6312156 ¶ 4394 4396 W4283747106.pdf 4 23 paratext 0.9813752 Frontiers in Cellular and Infection Microbiology | www.frontiersin.org June 2022 | Volume 12 | Article 926460 5 4396 4508 W4283747106.pdf 4 0 contact 0.99330306 * Corresponding author: mtgencoglu23@gmail.com 0 46 W2763286043.pdf 0 1 separator 0.98142177 "¶ ¶" 48 59 W2763286043.pdf 0 2 title 0.9672996 "Cryptanalysis of Application of Laplace Transform for Cryptography" 59 129 W2763286043.pdf 0 3 separator 0.9465109 ¶ 131 133 W2763286043.pdf 0 4 contact 0.98892856 "Muharrem Tuncay GENÇOĞLU* Vocational School of Technical Sciences, Firat University, Elazig, Turkey" 133 237 W2763286043.pdf 0 5 separator 0.9778278 ¶ ¶ 239 245 W2763286043.pdf 0 6 text 0.9983106 "Abstract . Although Laplace Transform is a good application field in the design of cryptosystems, many cryptographic algorithm proposals become unsatisfactory for secure communication. In this cryptanalysis study, one of the significant disadvantages of the proposed algorithm is performed with only statistical test of security analysis. In this study, Explaining what should be considered when performing security analysis of Laplace Transform based encryption systems and using basic mathematical rules, password has broken without knowing secret key. Under the skin; This study is a refutation for the article titled Application of Laplace Transform for Cryptography written by Hiwerakar[3]." 245 960 W2763286043.pdf 0 7 separator 0.9917908 ¶ 962 964 W2763286043.pdf 0 8 text 0.50049794 Keywords: Laplace Transform; Cryptography; Cryptanalysis; A general attack scenari o. 964 1051 W2763286043.pdf 0 9 separator 0.634006 "¶ ¶" 1052 1062 W2763286043.pdf 0 10 paratext 0.33146006 "¶ ¶ ¶" 1065 1080 W2763286043.pdf 0 11 separator 0.4231145 1082 1083 W2763286043.pdf 0 12 paratext 0.36423743 ¶ 1083 1084 W2763286043.pdf 0 13 separator 0.70922655 "¶ ¶" 1086 1096 W2763286043.pdf 0 14 paratext 0.9773534 "ITM Web of Conferences 13, 01009 (2017) DOI: 10.1051/itmconf/20171301009 CMES2017" 1096 1180 W2763286043.pdf 0 15 separator 0.567961 ¶ 1180 1182 W2763286043.pdf 0 16 paratext 0.97738355 "© The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/)." 1182 1382 W2763286043.pdf 0 0 paratext 0.98483086 102 0 3 W576304626.pdf 1 1 separator 0.8058853 ¶ 3 5 W576304626.pdf 1 2 paratext 0.97966814 Uroš Stepišnik / Dela 41 ● 2014 ● 101–1151. 5 49 W576304626.pdf 1 3 title 0.9858599 INTRODUCTION 49 62 W576304626.pdf 1 4 separator 0.9954285 ¶ 62 64 W576304626.pdf 1 5 text 0.990959 "The Dinaric Alps are one of the largest contiguous mountain belts of the European part of the Eurasian orogen, with a total length of 645 km and a width of approximately 150 km." 64 245 W576304626.pdf 1 6 separator 0.78437316 ¶ 246 248 W576304626.pdf 1 7 text 0.99977803 They are positioned between the Pannonian Basin in the northeast and the Adriatic Sea in the southwest. The Dinaric Alps are separated into different natural belts in which morphol-ogy is strongly influenced by differences in lithology. Inland, non-carbonate rocks hosting fluvial relief prevail, while the central and outer belts are formed mostly of limestone and dolomite – therefore karst landscape prevails. Characteristic forms associated with the karst area of the Dinaric Alps are extensive mountains, large levelled corrosion plains and intra-montane basins which host poljes (Mihevc, 2010). Whole surface is dissected by smaller karst features such as uvalas, dolines, canyons, dry valleys and collapse dolines. 248 970 W576304626.pdf 1 8 separator 0.85410106 ¶ 970 972 W576304626.pdf 1 9 text 0.9985795 "Poljes are the largest enclosed depressions in karst. Their size distinguishes them from other depressions, as do their large flat floors. There are about 130 poljes in the Dinaric karst region (Gams, 1978). Most of them are elongated along the strike of the Dinaric Alps which runs in a northwest–southeast direction, as most of them developed along regional fault lines, graben structures or overthrusts." 972 1382 W576304626.pdf 1 10 separator 0.9951261 ¶ 1382 1384 W576304626.pdf 1 11 caption 0.9638469 Figure 1: Location of the study areaSlika 1: Lega preučevanega območja 1384 1455 W576304626.pdf 1 12 separator 0.9945631 ¶ 1455 1457 W576304626.pdf 1 13 paratext 0.9858964 Dela_41_notranjost_FINAL.indd 102 6.1.2015 10:12:13 1457 1513 W576304626.pdf 1 0 paratext 0.98655957 Molecules 2023 ,28, 7076 5 of 20 0 32 W4387617977.pdf 4 1 separator 0.98790705 ¶ 32 34 W4387617977.pdf 4 2 text 0.99952567 "+2 and determine the formation of a palladium complex in the sample [ 69,70]. Figure 3B shows a C 1s spectrum, and the major peak at about 284.5 eV can be attributed to the sp2-hybridized carbon atoms present in the MWCNT backbone [ 71]. A peak at 285.2 eV relates to sp3C–C bonds, typical for MWCNTs. The peaks at 286.4, 287.7, 289.4, and 291.0 eV correspond to C–O bonds, C=O carbonyl groups, O–C=O carboxyl groups, and –*, respectively [ 71–73]. Figure 3C shows the deconvoluted peaks of O 1s at 532.5 eV and 533.9 eV , attributed to C=O and C–O–H groups, respectively. [ 56,57,74]. Moreover, a peak at 168.4 eV , which refers to S 2p, was recorded in the spectrum (Figure 3D). It indicates the presence of oxidized sulfur from the sulfonic group, typical for lignosulfonate [56,57]." 34 839 W4387617977.pdf 4 3 separator 0.9889971 ¶ 839 841 W4387617977.pdf 4 4 paratext 0.98920685 Molecules 2023 , 28, 7076 5 of 21 841 876 W4387617977.pdf 4 5 separator 0.97497165 ¶ ¶ 877 883 W4387617977.pdf 4 6 text 0.9995179 "tion of these two peaks and their characteristic s indicate the presence of palladium in the formal oxidation state +2 and determine the formation of a palladium complex in the sample [69,70]. Figure 3B shows a C 1s spectrum, and the major peak at about 284.5 eV can be attributed to the sp2-hybridized carbon atoms present in the MWCNT backbone [71]. A peak at 285.2 eV relates to sp3 C–C bonds, typical for MWCNTs. The peaks at 286.4, 287.7, 289.4, and 291.0 eV correspon d to C–O bonds, C=O carbonyl groups, O–C=O carboxyl groups, and π–π*, respectively [71–73]. Figure 3C shows the deconvoluted peaks of O 1s at 532.5 eV and 533.9 eV , attributed to C=O and C–O–H groups, respective- ly. [56,57,74]. Moreover, a peak at 168.4 eV , which refers to S 2p, was recorded in the spectrum (Figure 3D). It indicates the pres ence of oxidized sulfur from the sulfonic group, typical for lignosulfonate [56,57]." 884 1820 W4387617977.pdf 4 7 separator 0.992182 ¶ ¶ 1821 1827 W4387617977.pdf 4 8 caption 0.9955892 "Figure 3. XPS spectrum recorded for MWCN T/LS/NPd hybrid material: ( A) Pd 3d, ( B) C 1s, ( C) O 1s, and ( D) S 2p." 1827 1946 W4387617977.pdf 4 9 separator 0.99556327 ¶ 1948 1950 W4387617977.pdf 4 10 title 0.99446845 2.2. Physicochemical Analysis of MWCNT/LS/NPd 1950 1996 W4387617977.pdf 4 11 separator 0.9938711 ¶ 1997 1999 W4387617977.pdf 4 12 text 0.9996606 "The study of the morphology of palladium nanoparticles on the lignosulfonate- coated carbon nanotubes was performed using AFM microscopy. Figure 4 shows the AFM picture with cross-sections and 3D visualization for MWCNT/LS/NPd. The average value of the diameter of the developed material in the cross-section is about 70.69 ± 7.77 nm, which indicates good coverage of the MWCNT surface by LS and numerous Pd nanostructures. Compared to the average cr oss-sectional diameters of pure MWCNTs (39.25 ± 3.74 nm) and MWCNT/LS (48.20 ± 7.42 nm) presented in our previous work [57], it is concluded that the synthesis effectively resulted in a modified MWCNT/LS/NPd hybrid material with a differentiated surf ace area. Nanostructured palladium seems to be uniformly dispersed throughout the composit e. Metallic objects in the form of spheri- cal particles have been detected within the MWCNT/LS matrix. Moreover, the rough surface of the MWCNT/LS/NPd can be observed. The average roughness of the material is 2.62 ± 1.21 nm and is much higher than the average roughness of pristine MWCNTs" 1999 3115 W4387617977.pdf 4 13 separator 0.9945165 ¶ 3116 3118 W4387617977.pdf 4 14 caption 0.9958664 "Figure 3. XPS spectrum recorded for MWCNT/LS/NPd hybrid material: ( A) Pd 3d, ( B) C 1s, ( C) O 1s, and ( D) S 2p." 3118 3235 W4387617977.pdf 4 15 separator 0.9954116 ¶ 3235 3237 W4387617977.pdf 4 16 title 0.99426407 2.2. Physicochemical Analysis of MWCNT/LS/NPd 3237 3283 W4387617977.pdf 4 17 separator 0.9944971 ¶ 3283 3285 W4387617977.pdf 4 18 text 0.9996693 "The study of the morphology of palladium nanoparticles on the lignosulfonate-coated carbon nanotubes was performed using AFM microscopy. Figure 4 shows the AFM picture with cross-sections and 3D visualization for MWCNT/LS/NPd. The average value of the diameter of the developed material in the cross-section is about 70.69 7.77 nm, which indicates good coverage of the MWCNT surface by LS and numerous Pd nanostructures." 3285 3715 W4387617977.pdf 4 19 separator 0.936089 ¶ 3715 3717 W4387617977.pdf 4 20 text 0.9996702 "Compared to the average cross-sectional diameters of pure MWCNTs ( 39.253.74 nm ) and MWCNT/LS (48.20 7.42 nm) presented in our previous work [ 57], it is concluded that the synthesis effectively resulted in a modified MWCNT/LS/NPd hybrid material with a differ- entiated surface area. Nanostructured palladium seems to be uniformly dispersed through- out the composite. Metallic objects in the form of spherical particles have been detected within the MWCNT/LS matrix. Moreover, the rough surface of the MWCNT/LS/NPd can be observed. The average roughness of the material is 2.621.21 nm and is much higher than the average roughness of pristine MWCNTs ( 0.300.07 nm ) and MWCNT/LS (1.490.60 nm ). This is due to the presence of multiple palladium structures deposited on the MWCNT/LS in the reduction process." 3717 4550 W4387617977.pdf 4 0 paratext 0.9866098 Page 24 of 28 Lee et al. Int J Educ Technol High Educ (2024) 21:16 0 76 W4392342858.pdf 23 1 separator 0.99056995 ¶ 77 79 W4392342858.pdf 23 2 title 0.9903256 Future directions 79 97 W4392342858.pdf 23 3 separator 0.9948558 ¶ 97 99 W4392342858.pdf 23 4 text 0.9992053 "Based on the findings and limitations of this study, several directions for future research can be suggested. First, future studies can extend the scope of this study by investigat - ing the effects of the GCLA on other aspects of students’ learning, such as motivation, interest, satisfaction, and attitude. These aspects are also important for students’ learn - ing success and well-being, and can provide a more comprehensive picture of the impact of the GCLA. Second, future studies can explore the underlying mechanisms and factors that mediate or moderate the effects of the GCLA on students’ learning. For example, how does the GCLA influence students’ cognitive processes, metacognitive strategies, and affective states? How do students’ prior knowledge, learning styles, and preferences affect their use and perception of the GCLA? These questions can help to explain the reasons and conditions for the effectiveness of the GCLA, and provide more insights for its improvement and optimization. Third, future studies can compare the GCLA with other ChatGPT-based tools or interventions, such as those that provide different types or levels of feedback, scaffolding, or personalization. These comparisons can help to identify the strengths and weaknesses of the GCLA, and provide more evidence for its relative advantages and disadvantages." 99 1490 W4392342858.pdf 23 5 separator 0.9972896 ¶ 1490 1492 W4392342858.pdf 23 6 title 0.98665124 Acknowledgements 1492 1509 W4392342858.pdf 23 7 separator 0.99548215 ¶ 1509 1511 W4392342858.pdf 23 8 text 0.9988209 We are extremely grateful to the research assistants and students who participated in this study. 1511 1609 W4392342858.pdf 23 9 separator 0.9968074 ¶ 1609 1611 W4392342858.pdf 23 10 title 0.989373 Author contributions 1611 1632 W4392342858.pdf 23 11 separator 0.99490494 ¶ 1632 1634 W4392342858.pdf 23 12 text 0.9991537 "H‐YL is the leader of this research, he is in charge of the research design, conducting teaching and learning experiment, data analysis. P ‐HC is responsible for assisting in the conduct of experiments and surveying related literature. W ‐SW is responsible for assisting in the conduct of experiments. Y ‐MH is responsible for designing research experiments, providing fundamental education theories and comments to this research, and he is also responsible for revising the manuscript. All authors spent more than 2 months to discuss and analyze the data. The author(s) read and approved the final manuscript. T ‐TW is responsible for assisting in the conduct of experiments and surveying related literature and proofreading the manuscript." 1634 2394 W4392342858.pdf 23 13 separator 0.9969492 ¶ 2394 2396 W4392342858.pdf 23 14 title 0.9882884 Funding 2396 2404 W4392342858.pdf 23 15 separator 0.9945433 ¶ 2404 2406 W4392342858.pdf 23 16 text 0.99879855 "This project was funded by the National Science and Technology Council (NSTC), of the Republic of China under Con‐ tract numbers NSTC 110–2511‐H‐006–008‐MY3, NSTC 112–2410‐H‐006–053‐MY3." 2406 2595 W4392342858.pdf 23 17 separator 0.9970063 ¶ 2595 2597 W4392342858.pdf 23 18 title 0.9905681 Availability of data and materials 2597 2632 W4392342858.pdf 23 19 separator 0.99307525 ¶ 2632 2634 W4392342858.pdf 23 20 text 0.99822474 "The datasets used or analyzed during the current study are available from the corresponding author on reasonable request." 2634 2759 W4392342858.pdf 23 21 separator 0.99672866 ¶ 2759 2761 W4392342858.pdf 23 22 title 0.98677284 Declarations 2761 2774 W4392342858.pdf 23 23 separator 0.980989 ¶ 2774 2776 W4392342858.pdf 23 24 title 0.9880138 Competing interests 2776 2796 W4392342858.pdf 23 25 separator 0.9837481 ¶ 2796 2798 W4392342858.pdf 23 26 text 0.99710816 "The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper." 2798 2972 W4392342858.pdf 23 27 separator 0.99203134 ¶ 2972 2974 W4392342858.pdf 23 28 paratext 0.97424597 Received: 8 November 2023 Accepted: 9 February 2024 2974 3028 W4392342858.pdf 23 29 separator 0.99339056 ¶ 3028 3030 W4392342858.pdf 23 30 title 0.9609834 References 3030 3041 W4392342858.pdf 23 31 separator 0.99230033 ¶ 3041 3043 W4392342858.pdf 23 32 bibliography 0.9976715 "Abramski, K., Citraro, S., Lombardi, L., Rossetti, G., & Stella, M. (2023). Cognitive network science reveals bias in GPT ‐3, GPT ‐ 3.5 Turbo, and GPT ‐4 mirroring math anxiety in high‐school students. Big Data and Cognitive Computing, 7(3), 124. https:// doi. org/ 10. 3390/ bdcc7 030124" 3043 3337 W4392342858.pdf 23 33 separator 0.9811127 ¶ 3337 3339 W4392342858.pdf 23 34 bibliography 0.997979 "Adeshola, I., & Adepoju, A. P . (2023). The opportunities and challenges of ChatGPT in education. Interactive Learning Environments. https:// doi. org/ 10. 1080/ 10494 820. 2023. 22538 58" 3339 3530 W4392342858.pdf 23 35 separator 0.97845316 ¶ 3530 3532 W4392342858.pdf 23 36 bibliography 0.9978894 "Al‐Husban, N. A. (2020). Critical thinking skills in asynchronous discussion forums: A case study. International Journal of Technology in Education, 3(2), 82–91." 3532 3697 W4392342858.pdf 23 37 separator 0.9745277 ¶ 3697 3699 W4392342858.pdf 23 38 bibliography 0.99801314 "Al Mamun, M. A., & Lawrie, G. (2023). Student ‐content interactions: Exploring behavioural engagement with self‐ regulated inquiry‐based online learning modules. Smart Learning Environments, 10(1), 1. https:// doi. org/ 10. 1186/" 3699 3931 W4392342858.pdf 23 39 separator 0.96773624 ¶ 3932 3934 W4392342858.pdf 23 40 bibliography 0.8827067 s40561‐ 022‐ 00221‐x 3934 3955 W4392342858.pdf 23 0 text 0.97494256 "of the MOOC. Data was fully de-identified prior to analysis." 0 62 W2788601299.pdf 4 1 separator 0.99154925 ¶ 62 64 W2788601299.pdf 4 2 text 0.9991383 "A total of 1156 people enrolled in the Dying2Learn MOOC with 895 (77.4%) subsequently participating in some content or activity in the MOOC. A total of 210 MOOC participants completed the MOOC evaluation activity in the final week, representing 18.2% of those who initially enrolled in the MOOC, and 23.5% of those who had commenced participation in the MOOC. Of these, 208 had matched data from both the enrolment and the final activity on death attitudes which allowed a pre-post assessment of change in death attitudes." 64 605 W2788601299.pdf 4 3 separator 0.99597776 ¶ 605 607 W2788601299.pdf 4 4 title 0.97702765 Measures 607 616 W2788601299.pdf 4 5 separator 0.99417305 ¶ 616 618 W2788601299.pdf 4 6 text 0.999692 "Socio-Demographic Background was collected through five questions at the point of MOOC enrolment. Partici- pants were asked to provide their age in years, and the gender they identify with (with 5 options of male, fe- male, Trans, other, or prefer not to disclose). Given the very small number of participants utilizing the latter 3 options ( n= 14), where gender was included in analyses it was dichotomized to compare males and females (with the remainder coded as missing). Regarding occupation, participants identified themselves on the dichotomous categorization as either a health professional or not a health professional. They were also asked to report their highest level of education they had completed based on a four-category ordinal scale adapted from the Austra- lian Bureau of Statistics 2016 census [ 23] (some high school, completed high school, trade school/equivalent, and university studies). For the purpose of analysis, edu- cation was also dichotomized to compare those with university qualifications to those without university qual- ifications. Participants ’4-digit Australian residential postcode was recorded if they lived in Australia, or alter- natively the name of the country they resided in if they were not located in Australia. For participants residing in Australia ( n= 1078), the Socio-Economic Index for Areas (SEIFA) Index of Relative Socio-Economic Disad- vantage (IRSD) corresponding to their residential post- code was assigned, which is based on 2011 census data from the Australian Bureau of Statistics [ 24]. The 2011 Census SEIFA Disadvantage Index ranks 2481 postal areas in Australia according to relative disadvantage. It summarizes a range of information about the economic and social conditions of people and households within each area. Scores based on the 2011 Census can range from 506.3 to 1155.5, with low scores indicating greater disadvantage in that area (i.e., many households with un- employment, low income, no qualifications, and low skilled occupations). Higher scores on the SEIFA Disad- vantage index indicate that the postal area has a relative lack of disadvantage (i.e., few households with un- employment, low incomes, no qualifications, and lowskilled occupations) [ 24]. In the present study, SEIFA Disadvantage scores ranged from 744 to 1155.5." 618 3017 W2788601299.pdf 4 7 separator 0.9930121 ¶ 3017 3019 W2788601299.pdf 4 8 text 0.99843264 "Death Attitudes were measured with five items de- signed for the purpose of evaluating the impact of par- ticipation in the Dying2Learn MOOC, and were representative of the learning objectives of the MOOC." 3019 3231 W2788601299.pdf 4 9 separator 0.7050103 ¶ 3231 3233 W2788601299.pdf 4 10 text 0.99954766 "These items were presented both at enrolment (baseline) and at the end of the MOOC in a final activity (follow- up), to allow the assessment of change over time in death attitudes. Participants were asked to rate their level of agreement with five statements on a five-point Likert scale of ‘strongly disagree ’,‘disagree ’,‘not sure ’, ‘agree ’and ‘strongly agree ’. The statements (listed in Table 2) investigated attitudes towards death as a normal part of life, level of comfort in talking about death, and about how death and dying are presented in the main- stream media and social media." 3233 3848 W2788601299.pdf 4 11 separator 0.992158 ¶ 3848 3850 W2788601299.pdf 4 12 text 0.9993813 "MOOC Satisfaction was measured with six items at the end of the MOOC in a final evaluation activity. The items were adapted from evaluations of courses/work- shops related to death and palliative care [ 25,26]. Partic- ipants were asked to respond to six statements on a five- point Likert scale from ‘strongly disagree ’to ‘strongly agree ’. This assessed opinions on whether: the MOOC was enjoyable; it met expectations; they would recom- mend it to others; they would feel comfortable talking about MOOC content to others; and the MOOC had given them a deeper understanding of death, and helped them gain insight into personal beliefs." 3850 4511 W2788601299.pdf 4 13 separator 0.9904692 ¶ 4511 4513 W2788601299.pdf 4 14 text 0.9992123 "MOOC Engagement metrics were automatically gener- ated by the OpenLearning MOOC platform, and were extracted from the platform after the closure of the MOOC. The total percentage of course progress gave an indicator of the level of engagement for each participant based on the overall proportion of all content pages accessed and activities completed. A count score on the total number of comments made throughout the MOOC was also provided." 4513 4971 W2788601299.pdf 4 15 separator 0.9956782 ¶ 4971 4973 W2788601299.pdf 4 16 title 0.9887944 Statistical approach 4973 4994 W2788601299.pdf 4 17 separator 0.9956533 ¶ 4994 4996 W2788601299.pdf 4 18 text 0.9954534 "This study analyses data based on enrolment in the MOOC, MOOC engagement, and evaluation of the MOOC embedded in a final activity of the course. On completion of the MOOC, data extraction was facilitated by the team at OpenLearning, and was de-identified prior to data analyses. All analyses included a large sam- ple size (ranging from a minimum of n= 179 up to n= 1156), therefore providing adequate statistical power to the analyses. Descriptive statistics were produced for each variable (means and standard deviations for con- tinuous and ordinal variables, or proportions for cat- egorical variables). Chi-Square Tests of Independence were conducted to assess the extent of the relationship be- tween categorical variables. Socio-demographic variables" 4996 5780 W2788601299.pdf 4 19 paratext 0.97841305 Tieman et al. BMC Palliative Care (2018) 17:31 Page 5 of 16 5780 5840 W2788601299.pdf 4 0 paratext 0.9668315 "169 Шибер, О.О. Практики рекреаційного дозвілля у просторі «життєвого світу»Issues in Cultural Studies 2019 • 35 • 168-178CULTURAL PRACTICES ISSN 2410-1311 (Print) ISSN 2616-4264 (Online)" 0 198 W2998252643.pdf 1 1 title 0.83548045 Вступ 198 203 W2998252643.pdf 1 2 separator 0.9955454 ¶ 205 207 W2998252643.pdf 1 3 text 0.9996293 "Поняття життєвого світу нині широко використовується в культурологічних, соціологічних, філософських дослідженнях повсякденності, де дозвіллю та ре - креації як індивідуальному цінному, насамперед для індивіда, часу належить одна з провідних ролей. Водночас трансформаційні процеси, що відбуваються в сучасній Україні і пов’язані із впровадженням інформаційно-комунікативних, «високих» технологій, спричиняють «атомізацію» особистісного буття, сприяю - чи створенню «віртуального» образу повсякденної реальності – «віртуального життєвого світу». Ці зміни засвідчують розмивання меж між реальністю та ір - реальністю, де індивід, занурюючись у нові «правила гри» віртуального жит - тєвого світу, отримує й нові знання та досвід, які не завжди адекватно відобра - жають дійсність перебігу власного життя. Буденна свідомість та повсякденна реальність перестають опосередковуватися на раціональних схемах і розгорну - тих доказах як непотрібних атрибутах минулої епохи, спонукаючи до глибшого осмислення проблем сучасної гуманізації суспільства й людського буття. Прак - тики рекреаційного дозвілля в контексті «життєвого світу» людини техногенної цивілізації здатні забезпечити не тільки відновлення втрачених життєвих сил людини, а й сприяти її самореалізації та самовдосконаленню, досягти макси - мального синергетично-рекреаційного ефекту відновлення, гармонізації інтере - сів і потреб." 207 1640 W2998252643.pdf 1 4 separator 0.9921987 ¶ 1641 1643 W2998252643.pdf 1 5 text 0.9871082 "Окремі аспекти дослідження категорії «життєвий світ» висвітлено в працях вітчизняних і зарубіжних науковців." 1643 1755 W2998252643.pdf 1 6 separator 0.8875033 ¶ 1755 1757 W2998252643.pdf 1 7 text 0.9996358 "Зокрема, Е. Гуссерль (2013) пов’язує «життєвий світ» зі світом повсякден - ності, який, у свою чергу, окреслює простір здорового глузду в межах соціаль - ної феноменології. А. Шюц (2004) у модусі «життєвого світу» визначає характе - ристики повсякденного життя і також робить припущення про конституювання і конструювання світу. Ю. Хабермас (2001), у свою чергу, трактує поняття «жит - тєвого світу» як «необхідний фон», «необхідний горизонт» комунікації тріади «суспільство – особистість – культура». Г. Жигунова (2015) розглядає категорію «життєвий світ» як одну з ключових характеристик соціального феномену – по- всякденності. «Життєвий світ» людини як сенсовий універсум культури дослі - джує вітчизняна вчена А. Залужна (2012); «життєвий світ» у контексті культурно- дозвіллєвої діяльності проаналізовано Є. Сидоровською (2018), однак мало - дослідженою залишається проблема ефективності освоєння рекреаційно- дозвіллєвими практиками в просторі життєвого світу людини, що й зумовлює актуальність вивчення даного концепту." 1757 2820 W2998252643.pdf 1 8 separator 0.9955811 ¶ 2820 2822 W2998252643.pdf 1 9 title 0.9692304 Мета статті 2822 2834 W2998252643.pdf 1 10 separator 0.99285275 ¶ 2836 2838 W2998252643.pdf 1 11 text 0.9974076 "Визначити особливості реалізації практик рекреаційного дозвілля у просторі життєвого світу і з’ясувати ступінь ефективності їхнього освоєння." 2838 2983 W2998252643.pdf 1 12 separator 0.9832209 ¶ 2984 2986 W2998252643.pdf 1 13 text 0.9995335 "Методологія дослідження зумовлена необхідністю застосування культуро - логічного, мікросоціологічного та філософського підходів для аналізу сфери дозвілля і рекреації у рамках «життєвого світу». Мікросоціологічний підхід доз - воляє розглянути інтеракцію (рекреаційно-дозвіллєвої взаємодії індивідів) як ос - нови цілісності життєвого світу. Філософський – вплив виду і змісту рекреаційно-" 2986 3385 W2998252643.pdf 1 0 paratext 0.9665028 5406 H. Suto et al.: TIR spectral radiance characterization for TANSO-FTS-2 onboard GOSAT-2 0 91 W4291123792.pdf 7 1 separator 0.9946236 ¶ 91 93 W4291123792.pdf 7 2 caption 0.9958734 "Figure 4. Comparing TANSO-FTS-2 with other sounders: coincident latitude and longitude map between TANSO-FTS-2 and AIRS/IASI/TANSO-FTS for SNO (a)and 2O-SONO (b)." 93 258 W4291123792.pdf 7 3 separator 0.97394526 ¶ 258 260 W4291123792.pdf 7 4 text 0.9984911 "tures. The consistency between TANSO-FTS-2 and TANSO- FTS agrees in these regions. In other words, version v210210 of TANSO-FTS-2 products removes the low-temperature bi- ases, even though TANSO-FTS version v230231 still has lower temperature biases." 260 519 W4291123792.pdf 7 5 separator 0.9904569 ¶ 519 521 W4291123792.pdf 7 6 caption 0.7399356 Figure 6 presents the time series of the brightness temper- 521 581 W4291123792.pdf 7 7 text 0.4842436 581 582 W4291123792.pdf 7 8 caption 0.763157 "¶ ature difference between TANSO-FTS-2 and IASI, between TAN" 582 644 W4291123792.pdf 7 9 text 0.49749509 SO 644 646 W4291123792.pdf 7 10 caption 0.6648561 - 646 647 W4291123792.pdf 7 11 text 0.504921 FTS 647 650 W4291123792.pdf 7 12 caption 0.8922891 "-2 and AIRS, and between TANSO-FTS-2 and TANSO-FTS for four spectral ranges, both versions v210210" 650 750 W4291123792.pdf 7 13 separator 0.39902923 ¶ 750 752 W4291123792.pdf 7 14 caption 0.6499252 and v1021 752 762 W4291123792.pdf 7 15 text 0.9914064 "02. During winter in the Southern Hemisphere, the version v102102 products present negative values and large deviations due to seasonal variation, especially in the CO2and CH 4spectral ranges. Cold temperature scenes over Antarctica were selected as coincident observation locations." 762 1053 W4291123792.pdf 7 16 separator 0.9153584 ¶ 1053 1055 W4291123792.pdf 7 17 text 0.99945813 "In contrast, version v210210 products suggest no seasonal variation except for a comparison with the first TANSO-FTS instrument. These plots also indicate that version v230231of TANSO-FTS products has a negative bias against cold scenes, observed over high-latitude coincident points." 1055 1345 W4291123792.pdf 7 18 separator 0.96661305 ¶ 1345 1347 W4291123792.pdf 7 19 text 0.9992052 "As a result of SNO, version v210210 of TANSO-FTS-2 products shows that the averaged bias is less than 0:3 K for all four ranges. In addition, the deviations against IASI and AIRS for the CO 2and CH 4spectral ranges are less than 0.3 and 0.5 K, respectively. These results suggest that the consistency for the CO 2and CH 4spectral ranges be- tween TANSO-FTS-2 and AIRS, between TANSO-FTS- 2 and IASI, is much improved. The comparison between TANSO-FTS-2 and TANSO-FTS shows a significant differ- ence for low-temperature scenes, but we have to conclude that version v230231 of the TANSO-FTS product has a chal- lenging issue at low temperatures, especially at high lati- tudes, for both CO 2and CH 4spectral ranges. Therefore, the calibration of the TIR band for TANSO-FTS will be up- dated in the next version of the level 1 product to improve" 1347 2219 W4291123792.pdf 7 20 separator 0.9415022 ¶ 2219 2221 W4291123792.pdf 7 21 paratext 0.98504364 Atmos. Meas. Tech., 15, 5399–5413, 2022 https://doi.org/10.5194/amt-15-5399-2022 2221 2302 W4291123792.pdf 7 0 bibliography 0.99794656 "34. Boyle AP, Davis S, Shulha HP, Meltzer P, Margulies EH, Weng Z, Furey TS, Crawford GE. High-resolution mapping and characterization of open chromatin across the genome. Cell. 2008;132(2):311 –22." 0 202 W2949216407.pdf 11 1 separator 0.97130024 ¶ 202 204 W2949216407.pdf 11 2 bibliography 0.9977897 "35. Giresi PG, Lieb JD. Isolation of active regulatory elements from eukaryotic chromatin using FAIRE (formaldehyde assisted isolation of regulatory elements). Methods. 2009;48(3):233 –9." 204 396 W2949216407.pdf 11 3 separator 0.9681212 ¶ 396 398 W2949216407.pdf 11 4 bibliography 0.9963861 "36. Song L, Crawford GE. DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells. Cold Spring Harb Protoc. 2010;2010(2):pdb. prot5384." 398 603 W2949216407.pdf 11 5 separator 0.9717696 ¶ 603 605 W2949216407.pdf 11 6 bibliography 0.9978812 "37. Zhou VW, Goren A, Bernstein BE. Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet. 2011;12(1):7." 605 757 W2949216407.pdf 11 7 separator 0.97099483 ¶ 757 759 W2949216407.pdf 11 8 bibliography 0.9979348 "38. Hiatt JB, Pritchard CC, Salipante SJ, O'Roak BJ, Shendure J. Single molecule molecular inversion probes for targeted, high-accuracy detection of low- frequency variation. Genome Res. 2013;23(5):843 –54." 759 970 W2949216407.pdf 11 9 separator 0.8139623 ¶ • 970 974 W2949216407.pdf 11 10 text 0.5181803 We accept pre 975 989 W2949216407.pdf 11 11 title 0.47084773 - 989 990 W2949216407.pdf 11 12 text 0.86521864 "submission inquiries  Our selector tool helps you to find the most relevant journal  We provide round the clock customer support  Convenient online submission  Thorough peer review  Inclusion in PubMed and all major indexing services  Maximum visibility for your research" 990 1288 W2949216407.pdf 11 13 separator 0.63145304 ¶ 1288 1290 W2949216407.pdf 11 14 text 0.5905617 "Submit your manuscript at www.biomedcentral.com" 1290 1340 W2949216407.pdf 11 15 contact 0.444559 / 1340 1341 W2949216407.pdf 11 16 text 0.72288954 "submitSubmit your next manuscript to BioMed Central and we will help you at every step:Wu" 1341 1433 W2949216407.pdf 11 17 paratext 0.8779799 et al. BMC Genomics (2018) 19:143 Page 12 of 12 1433 1481 W2949216407.pdf 11 0 bibliography 0.99807495 "19. Jan S, Santin G, Strul D, Staelens S, Assié K, Autret D, et al. GATE: a simulation toolkit for PET and SPECT. Phys Med Biol 49(2004) 4543." 0 144 W3124366161.pdf 17 1 separator 0.9484066 ¶ 144 146 W3124366161.pdf 17 2 bibliography 0.9981241 "20. Jan S, Benoit D, Becheva E, Carlier T, Cassol F, Descourt P, et al. Gate V6: a major enhancement of the GATE simulation platform enabling modelling ofCT and radiotherapy. Phys Med Biol 56(2011) 881." 146 351 W3124366161.pdf 17 3 separator 0.9517114 ¶ 351 353 W3124366161.pdf 17 4 bibliography 0.9979316 "21. Sarrut D, Bardiès M, Boussion N, Freud N, Jan S, Létang J, et al. A review of the use and potential of the GATE Monte Carlo simulation code for radiationtherapy and dosimetry applications. Med Phys 41(2014) 64301. doi:10.1118/1. 4871617" 353 598 W3124366161.pdf 17 5 separator 0.97151077 ¶ 598 600 W3124366161.pdf 17 6 bibliography 0.99796176 "22. Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys 39(2012) 6818 –37. doi:10.1118/1.4758060" 600 800 W3124366161.pdf 17 7 separator 0.9460112 ¶ 800 802 W3124366161.pdf 17 8 bibliography 0.9980813 "23. Testa M, Schümann J, Lu HM, Shin J, Faddegon B, Perl J, et al. Experimental validation of the TOPAS Monte Carlo system for passive scattering protontherapy. Med Phys 40(2013) 121719. doi:10.1118/1.4828781" 802 1013 W3124366161.pdf 17 9 separator 0.9567013 ¶ 1013 1015 W3124366161.pdf 17 10 bibliography 0.9978868 "24. Jia X, Schümann J, Paganetti H, Jiang SB. GPU-based fast Monte Carlo dose calculation for proton therapy. Phys Med Biol 57(2012) 7783 –97. doi:10.1088/ 0031-9155/57/23/7783" 1015 1196 W3124366161.pdf 17 11 separator 0.9706673 ¶ 1196 1198 W3124366161.pdf 17 12 bibliography 0.99807763 "25. Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, et al. Recent developments and comprehensive evaluations of a GPU-based Monte Carlopackage for proton therapy. Phys Med Biol 61(2016) 7347." 1198 1405 W3124366161.pdf 17 13 separator 0.95806825 ¶ 1405 1407 W3124366161.pdf 17 14 bibliography 0.9980054 "26. Giantsoudi D, Schuemann J, Jia X, Dowdell S, Jiang S, Paganetti H. Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy:clinical cases study. Phys Med Biol 60(2015) 2257." 1407 1610 W3124366161.pdf 17 15 separator 0.93919396 ¶ 1610 1612 W3124366161.pdf 17 16 bibliography 0.9980556 "27. Wan Chan Tseung H, Ma J, Beltran C. A fast GPU-based Monte Carlo simulation of proton transport with detailed modeling of nonelasticinteractions. Med Phys 42(2015) 2967 –78. doi:10.1118/1.4921046" 1612 1814 W3124366161.pdf 17 17 separator 0.9601868 ¶ 1814 1816 W3124366161.pdf 17 18 bibliography 0.99801826 "28. Mein S, Choi K, Kopp B, Tessonnier T, Bauer J, Ferrari A, et al. Fast robust dose calculation on GPU for high-precision 1H, 4He, 12C and 16O ion therapy: the FRoG platform. Sci Rep 8(2018) 14829. doi:10.1038/s41598-018-33194-4" 1816 2051 W3124366161.pdf 17 19 separator 0.95051396 ¶ 2051 2053 W3124366161.pdf 17 20 bibliography 0.9980838 "29. Choi K, Mein SB, Kopp B, Magro G, Molinelli S, Ciocca M, et al. FRoG - a new calculation engine for clinical investigations with proton and carbon ion beamsat cnao. Cancers 10(2018) doi:10.3390/cancers10110395" 2053 2269 W3124366161.pdf 17 21 separator 0.96417797 ¶ 2269 2271 W3124366161.pdf 17 22 bibliography 0.9981101 "30. Ma CMC, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, et al. Beam modeling and beam model commissioning for Monte Carlo dose calculation-basedradiation therapy treatment planning: report of AAPM Task Group 157.Med Phys 47(2020) e1 –e18. doi:10.1002/mp.13898" 2271 2536 W3124366161.pdf 17 23 separator 0.9651083 ¶ 2536 2538 W3124366161.pdf 17 24 bibliography 0.9978433 "31. Parodi K, Mairani A, Brons S, Hasch BG, Sommerer F, Naumann J, et al. Monte Carlo simulations to support start-up and treatment planning ofscanned proton and carbon ion therapy at a synchrotron-based facility.Phys Med Biol 57(2012) 3759." 2538 2782 W3124366161.pdf 17 25 separator 0.94633746 ¶ 2782 2784 W3124366161.pdf 17 26 bibliography 0.99799687 "32. Grevillot L, Bertrand D, Dessy F, Freud N, Sarrut D. A Monte Carlo pencil beam scanning model for proton treatment plan simulation using GATE/GEANT4. Phys Med Biol 56(2011) 5203." 2784 2969 W3124366161.pdf 17 27 separator 0.9466963 ¶ 2969 2971 W3124366161.pdf 17 28 bibliography 0.9978591 "33. Grassberger C, Lomax A, Paganetti H. Characterizing a proton beam scanning system for Monte Carlo dose calculation in patients. Phys Med Biol 60(2015) 633. doi:10.1088/0031-9155/60/2/633" 2971 3166 W3124366161.pdf 17 29 separator 0.96777 ¶ 3166 3168 W3124366161.pdf 17 30 bibliography 0.9980015 "34. Schiavi A, Senzacqua M, Pioli S, Mairani A, Magro G, Molinelli S, et al. Fred: a GPU-accelerated fast-Monte Carlo code for rapid treatment plan recalculationin ion beam therapy. Phys Med Biol 62(2017) 7482 –504. doi:10.1088/1361- 6560/aa8134" 3168 3418 W3124366161.pdf 17 31 separator 0.9758278 ¶ 3418 3420 W3124366161.pdf 17 32 bibliography 0.9978997 "35. Winterhalter C, Aitkenhead A, Oxley D, Richardson J, Weber DC, MacKay RI, et al. Pitfalls in the beam modelling process of Monte Carlo calculations forProton pencil beam scanning. Br J Radiol (2020) 20190919. doi:10.1259/bjr. 20190919" 3420 3663 W3124366161.pdf 17 33 separator 0.96944773 ¶ 3663 3665 W3124366161.pdf 17 34 bibliography 0.9973583 "36. Schneider U, Pedroni E, Lomax A. The calibration of CT Houns field units for radiotherapy treatment planning. Phys Med Biol 41(1996) 111.37. Varian Medical System Inc. Proton algorithm reference guide (Eclipse). Tech. Rep. August , Varian Medical Systems, Inc., Palo Alto (2013)" 3665 3951 W3124366161.pdf 17 35 separator 0.9659821 ¶ 3951 3953 W3124366161.pdf 17 36 bibliography 0.9976582 "38. ICRU. Report 90: Key data for ionizing-radiation dosimetry: measurement standards and applications. J Int Comm Radiation Units Measure 14(2016) 1–118. doi:10.1093/jicru/ndw029" 3953 4137 W3124366161.pdf 17 37 separator 0.956781 ¶ 4137 4139 W3124366161.pdf 17 38 bibliography 0.9978871 "39. Zhu RX, Poenisch F, Lii M, Sawakuchi GO, Titt U, Bues M, et al. Commissioning dose computation models for spot scanning proton beamsin water for a commercially available treatment planning system. Med Phys 40 (2013) 041723. doi:10.1118/1.4798229" 4139 4393 W3124366161.pdf 17 39 separator 0.96818805 ¶ 4393 4395 W3124366161.pdf 17 40 bibliography 0.9978679 "40. Langner UW, Eley JG, Dong L, Langen K. Comparison of multi-institutional Varian ProBeam pencil beam scanning proton beam commissioning data. J Appl Clin Med Phys 18(2017) 96 –107. doi:10.1002/acm2.12078" 4395 4606 W3124366161.pdf 17 41 separator 0.961277 ¶ 4606 4608 W3124366161.pdf 17 42 bibliography 0.99805474 "41. Almhagen E, Boersma DJ, Nyström H, Ahnesjö A. A beam model for focused proton pencil beams. Phys Med 52(2018) 27 –32. doi:10.1016/j.e jmp.2018.06.007" 4608 4764 W3124366161.pdf 17 43 separator 0.95373917 ¶ 4764 4766 W3124366161.pdf 17 44 bibliography 0.99800926 "42. Twiss RQ, Frank NH. Orbital stability in a proton synchrotron. Rev Sci Instrum 20(1949) 1 –17. doi:10.1063/1.1741343" 4766 4889 W3124366161.pdf 17 45 separator 0.90163827 ¶ 4889 4891 W3124366161.pdf 17 46 bibliography 0.99789786 "43. Bortfeld T. An analytical approximation of the Bragg curve for therapeutic proton beams. Med Phys 24(1997) 2024. doi:10.1118/1.598116" 4891 5031 W3124366161.pdf 17 47 separator 0.91351336 ¶ 5031 5033 W3124366161.pdf 17 48 bibliography 0.99775475 44. [Dataset]Gajewski J. Bragg peak analysis (2017) 5033 5085 W3124366161.pdf 17 49 separator 0.9215807 ¶ 5085 5087 W3124366161.pdf 17 50 bibliography 0.9979613 "45. Nelder JA, Mead R. A simplex method for function minimization. Comput J 7 (1965) 308 –13. doi:10.1093/comjnl/7.4.308" 5087 5210 W3124366161.pdf 17 51 separator 0.9458381 ¶ 5210 5212 W3124366161.pdf 17 52 bibliography 0.99805975 "46. Lin L, Ainsley CG, Mertens T, De Wilde O, Talla PT, McDonough JE. A novel technique for measuring the low-dose envelope of pencil-beam scanning spotprofiles.Phys Med Biol 58(2013) doi:10.1088/0031-9155/58/12/N171" 5212 5430 W3124366161.pdf 17 53 separator 0.93968296 ¶ 5430 5432 W3124366161.pdf 17 54 bibliography 0.99782765 "47. Lin L, Huang S, Kang M, Solberg TD, McDonough JE, Ainsley CG. Technical Note: validation of halo modeling for proton pencil beam spot scanning using aquality assurance test pattern. Med Phys 42(2015) 5138 –43. doi:10.1118/1. 4928157" 5432 5673 W3124366161.pdf 17 55 separator 0.9427321 ¶ 5673 5675 W3124366161.pdf 17 56 bibliography 0.9979083 "48. Low DA, Harms WB, Mutic S, Purdy JA. A technique for the quantitative evaluation of dose distributions. Med Phys 25(1998) 656 –61. doi:10.1118/1. 598248" 5675 5836 W3124366161.pdf 17 57 separator 0.9563712 ¶ 5836 5838 W3124366161.pdf 17 58 bibliography 0.9977875 49. Biggs S, Jennings M. PyMedPhys python package (2019) 5838 5895 W3124366161.pdf 17 59 separator 0.89225805 ¶ 5895 5897 W3124366161.pdf 17 60 bibliography 0.9978856 "50. Albertini F, Casiraghi M, Lorentini S, Rombi B, Lomax AJ. Experimental verification of IMPT treatment plans in an anthropomorphic phantom in the presence of delivery uncertainties. Phys Med Biol 56(2011) 4415 –31. doi:10. 1088/0031-9155/56/14/012" 5897 6153 W3124366161.pdf 17 61 separator 0.96219933 ¶ 6153 6155 W3124366161.pdf 17 62 bibliography 0.9977842 "51. ICRU. Report 83. Prescribing, recording, and reporting photon-beam intensity-modulated radiation therapy (IMRT). J Int Commission Radiation Units Measure 10(2010) 112." 6155 6331 W3124366161.pdf 17 63 separator 0.9415871 ¶ 6331 6333 W3124366161.pdf 17 64 bibliography 0.99789554 "52. Pathak P, Vashisht S. A quantitative analysis of intensity-modulated radiation therapy plans and comparison of homogeneity indices for the treatment of gynecological cancers. J Med Phys 38(2013) 67 –73. doi:10.4103/0971-6203." 6333 6567 W3124366161.pdf 17 65 separator 0.73664224 ¶ 6567 6569 W3124366161.pdf 17 66 bibliography 0.9413972 111309 6569 6576 W3124366161.pdf 17 67 separator 0.9866922 ¶ 6576 6578 W3124366161.pdf 17 68 text 0.8436269 "Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential con flict of interest." 6578 6775 W3124366161.pdf 17 69 separator 0.82325244 ¶ 6775 6777 W3124366161.pdf 17 70 paratext 0.96731377 Copyright © 2021 6777 6794 W3124366161.pdf 17 71 bibliography 0.98477924 "Gajewski, Garbacz, Chang, Czerska, Durante, Krah, Krzempek, Kopec, Lin, Mojzeszek, Patera, Pawlik-Niedzwiecka, Rinaldi, Rydygier, Pluta,Scifoni, Skrzypek, Tommasino, Schiavi and Rucinski. This is" 6794 6992 W3124366161.pdf 17 72 paratext 0.9058361 an open-accessarticle distributed under the terms of the Creative Commons Attribution License(CC BY). The use, distribution or reproduction in other forums is permitted,provided the original author(s) and the copyright owner(s) are credited and thatthe original publication in this journal is cited, in accordance with accepted academicpractice. No use, distribution or reproduction is permitted which does not complywith these terms. 6992 7427 W3124366161.pdf 17 73 separator 0.9295237 ¶ 7427 7429 W3124366161.pdf 17 74 paratext 0.9289964 Frontiers in Physics | www.frontiersin.org January 2021 | Volume 8 | Article 567300 18Gajewski 7429 7524 W3124366161.pdf 17 75 bibliography 0.5341503 et 7524 7527 W3124366161.pdf 17 76 paratext 0.607021 al. 7527 7531 W3124366161.pdf 17 77 bibliography 0.7503473 FREDMC for Proton Therapy 7531 7557 W3124366161.pdf 17 0 paratext 0.96720237 Mapping High-Level Applicat ion Requirements onto Low-Level Cloud Resources 897 0 80 W2031931181.pdf 3 1 separator 0.9577395 ¶ ¶ 80 86 W2031931181.pdf 3 2 caption 0.9881395 Figure 2. Categories of infrastructure requirements. 86 139 W2031931181.pdf 3 3 separator 0.7999308 ¶ ¶ 140 146 W2031931181.pdf 3 4 text 0.9988364 "requirement is. This can be us ed during the requirements prioritization and resources filtering phases. Require- ments may be inter-dependent. For example, the UK Data Protection Act (a compliance requirement) indicates that no data can be processed or stored outside the UK. This translates to a dependency relationship on geogra- phical requirement. Figure 3 provides an overview of the ontology for infrastructure requirements ." 146 596 W2031931181.pdf 3 5 separator 0.9806397 ¶ 597 599 W2031931181.pdf 3 6 text 0.9979333 "A class restriction is defined to identify the relevant conditions or constraints asso ciated with a requirement (see Figure 3 ). Each requirement is constrained by at least one restriction . The detailed ontology relationships between infrastructure requirements and restrictions are given below:" 599 915 W2031931181.pdf 3 7 separator 0.9055449 ¶ 916 918 W2031931181.pdf 3 8 text 0.9985334 " A cost requirement is constrained by cost restrictions. A cost restriction can be a total cost or it can be sub- divided into compute costs, software costs, storage costs, or bandwidth costs. Each cost restriction is as- sociated with cost frequenc y (per hour, per day) and financial cost (amount and currency)." 918 1240 W2031931181.pdf 3 9 separator 0.6068509 ¶ 1241 1243 W2031931181.pdf 3 10 text 0.9993385  A performance requirement is constrained by per- formance related restrictions. Network latency perfor- mance is constrained by latency restrictions. Incom- ing and outgoing bandwidth performances are cons- trained by bandwidth restrictions. Bandwidth restri- ction indicates the minimum amount of bandwidth required. 1243 1563 W2031931181.pdf 3 11 separator 0.6452123 ¶ 1564 1566 W2031931181.pdf 3 12 text 0.99773425 " A resource requirement is constrained by resource- related restrictions. 1) The hosting environment is constrained by operating system restriction wh ich specifies the operating sys- tem types. 2) The hardware capability is constrained by various hardware restrictions, such as minimum number of CPU cores, CPU speed, CPU architecture type, RAM, and storage space restriction. 3) The software stack is co nstrained by software res- trictions which specify the list of software or services that need to be installed on the resource." 1566 2124 W2031931181.pdf 3 13 separator 0.697625 ¶ 2126 2128 W2031931181.pdf 3 14 text 0.9976467 " Geographical requirement is constrained by location restrictions. Location restri ction indicates the location of resource or data processing.  Compliance code requirement is constrained by com- pliance restrictions, which can be industry’s standard restriction or regulatory restriction. Deployment specifications are expressed using layers: domain, site, group , and node (see Figure 4 ). A domain represents the top-layer of th e infrastructure deployment layout and has at least one site. A site is composed of one or more groups . A group contains a set of nodes which provide same functionality, such as web servers or data- bases. A node is a specific type of resource such as a computational unit or storage. The ontologies include requirements which apply to many different layers of the deployment structure. For example, if a location require- ment is applied at the domain layer, all sites , groups and nodes within the domain must fulfil the same location constraint; hardware requirements , such as CPU and memory, can be applied at group level or at individual node level." 2128 3270 W2031931181.pdf 3 15 separator 0.9453848 ¶ 3271 3273 W2031931181.pdf 3 16 text 0.9987003 "Once the infrastructure deployment specification is defined, it is then used to search for resources in the low- level resource pool." 3273 3411 W2031931181.pdf 3 17 separator 0.9965955 ¶ 3412 3414 W2031931181.pdf 3 18 title 0.9918623 3.3. Resource Ontology 3414 3437 W2031931181.pdf 3 19 separator 0.9962558 ¶ 3438 3440 W2031931181.pdf 3 20 text 0.9996435 "The resource ontology defines the properties of the resources offered by cloud providers. This layer has been widely investigated elsewher e [5,6]. In the proposed model, we adopt a similar approach as [6] (using the concept of resource capabilities) for describing cloud re- sources." 3440 3735 W2031931181.pdf 3 21 separator 0.9411658 ¶ 3736 3738 W2031931181.pdf 3 22 text 0.99733967 "A cloud resource is associated with different resource capabilities , which can be storage capability , compute capability, memory capability , software capability and host capability . Storage capability consists of amount of storage space and various storage types, such as local ¶" 3738 4040 W2031931181.pdf 3 23 separator 0.8563929 ¶ ¶ 4042 4048 W2031931181.pdf 3 24 caption 0.99326867 "Figure 3. Overview of infr astructure requirements ontol- ogy." 4048 4113 W2031931181.pdf 3 25 separator 0.8316471 "¶ ¶" 4114 4124 W2031931181.pdf 3 26 caption 0.9945821 Figure 4. Ontology for in frastructure deployment. 4124 4175 W2031931181.pdf 3 27 separator 0.9804312 ¶ 4176 4178 W2031931181.pdf 3 28 paratext 0.96758056 Copyright © 2012 SciRes. JSEA 4178 4289 W2031931181.pdf 3 0 paratext 0.58603936 REFERENCES 0 10 W3124890611.pdf 19 1 separator 0.9932605 ¶ 10 12 W3124890611.pdf 19 2 bibliography 0.995295 "Altenhoff AM, Studer RA, Robinsonrechavi M, Dessimoz C. 2012. Resolving the ortholog conjecture: orthologs tend to be weakly, but significantly, more sim- ilar in function than paralogs. PLOS Computational Biology 8(5):e1002514 DOI 10.1371/journal.pcbi.1002514." 12 280 W3124890611.pdf 19 3 separator 0.9870298 ¶ 280 282 W3124890611.pdf 19 4 bibliography 0.9976285 "Belenghi B, Acconcia F, Trovato M, Perazzolli M, Bocedi A, Polticelli F, Ascenzi P, Delledonne M. 2010. AtCYS1, a cystatin from Arabidopsis thaliana , suppresses hypersensitive cell death. European Journal of Biochemistry 270(12) :25932604 DOI 10.1046/j.1432-1033.2003.03630.x." 282 567 W3124890611.pdf 19 5 separator 0.9880315 ¶ 567 569 W3124890611.pdf 19 6 bibliography 0.9976213 "Chen PJ, Senthilkumar R, Jane WN, He Y, Tian Z, Yeh KW. 2014. 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Hvidberg et al.: Surface velocity of the Northeast Greenland Ice Stream (NEGIS) 3489 0 90 W4243055514.pdf 2 1 separator 0.9907421 ¶ 90 92 W4243055514.pdf 2 2 text 0.9990773 "quirements, the stake network contains sets of stakes placed in a diamond shape centered around the midpoint of NEGIS and at both shear margins. The stake network extends 35 km along NEGIS and 40 km across NEGIS, thereby covering the entire 25 km width of NEGIS and extending across both shear margins into the slower-moving regions outside the ice stream. The purpose of the additional stakes added in 2018 was to obtain detailed information of strain rates across a topographic surface undulation northwest of NEGIS (a 20– 30 km dark–bright pattern perpendicular to NEGIS, Fig. 2a)." 92 695 W4243055514.pdf 2 3 separator 0.98176014 ¶ 695 697 W4243055514.pdf 2 4 text 0.9948549 All stake observations are included in this analysis. 697 751 W4243055514.pdf 2 5 separator 0.94698215 ¶ 751 753 W4243055514.pdf 2 6 text 0.9996458 "The GPS observations were carried out with a Leica GX1230 GPS receiver with data acquisition lasting a min- imum of 1 h and typically 2–4 h. The GPS antenna was mounted on the top of each stake, and the height above the surface was measured manually. The stakes were 3.5 m long aluminum stakes, which were drilled approximately 2 m be- low the surface and extended when needed due to continuous snow accumulation in the area (approximately 0.3 m of snow equivalent per year; Vallelonga et al., 2014). All stakes es- tablished in 2015, 2016, and 2017 were extended during the observational period when the antenna heights decreased be- low 1 m above the surface. A few stakes were moved and/or replaced due to camp activities." 753 1503 W4243055514.pdf 2 7 separator 0.9615301 ¶ 1503 1505 W4243055514.pdf 2 8 text 0.99936306 "The GPS observations were postfield processed using the open-source software package ESA/UPC GNSS-Lab Tool (gLAB; Sanz Subirana et al., 2013; Ibáñez et al., 2018). We use the Center for Orbit Determination in Europe (CODE) final orbit and clock product, which includes Earth rotation parameters. We took the antenna phase center offset and vari- ation into account. Receiver clock parameters are modeled, and the atmosphere delay parameters are modeled using the CODE maps for the ionosphere and ESA’s Niell mapping function with simple nominal values for the troposphere. We applied solid Earth tidal corrections using the IERS Conven- tion’s degree 2 tides displacement model (Sanz Subirana et al., 2013). Ocean tidal correction is not implemented in the gLAB processing tool, and for our interior site the associ- ated error is estimated to be within 1 cm. The coordinates are computed in the IGS14 frame. We use the software in static mode and developed an automated protocol in order to perform a systematic precise point positioning (PPP) pro- cessing of the stake observations. The PPP approach can in- troduce systematic errors if the stake is moving (King, 2004)." 1505 2714 W4243055514.pdf 2 9 separator 0.9914086 ¶ 2714 2716 W4243055514.pdf 2 10 text 0.99944687 "To optimize our processing protocol and evaluate timing esti- mates and position uncertainties, we observed the central ref- erence stake at the EastGRIP site (red dot in Fig. 2) over ex- tended periods each season and compared separate 1 h static, 24 h static, and kinematic solutions. We found that the 24 h static solution performed better than the average position of a 24 h kinematic solution. With a maximum observed surface speed of approximately 60 m a" 2716 3191 W4243055514.pdf 2 0 paratext 0.9780366 nature cardiovascular research Volume 3 | January 2024 | 94 | 94 0 64 W4390898677.pdf 0 1 separator 0.9932177 ¶ 64 66 W4390898677.pdf 0 2 title 0.944274 Corrections & amendments Author Correction: Cardiometabolic and renal phenotypes 66 147 W4390898677.pdf 0 3 separator 0.7452848 ¶ 148 150 W4390898677.pdf 0 4 title 0.93838626 and transitions in the United States population 150 198 W4390898677.pdf 0 5 separator 0.95687175 ¶ 198 200 W4390898677.pdf 0 6 bibliography 0.9922282 "Victor P. F. Lhoste, Bin Zhou , Anu Mishra, James E. Bennett, Sarah Filippi, Perviz Asaria, Edward W. Gregg, Goodarz Danaei & Majid Ezzati" 200 345 W4390898677.pdf 0 7 separator 0.9579031 ¶ 349 351 W4390898677.pdf 0 8 text 0.9740451 "In the version of this article initially published, incorrect versions of Extended Data Figs. 1 and 2, with mismatched data and labels, were presented. The figures have been corrected in the HTML and PDF versions of the article." 351 587 W4390898677.pdf 0 9 separator 0.9752506 ¶ 587 589 W4390898677.pdf 0 10 paratext 0.9220829 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/." 589 1443 W4390898677.pdf 0 11 separator 0.72235644 ¶ 1443 1445 W4390898677.pdf 0 12 paratext 0.9630007 "© The Author(s) 2024Correction to: Nature Cardiovascular Research https://doi.org/10.1038/ s44161-023-00391-y , published online 15 December 2023. https://doi.org/10.1038/s44161-024-00425-z" 1445 1647 W4390898677.pdf 0 13 separator 0.5737201 ¶ 1647 1649 W4390898677.pdf 0 14 paratext 0.9485338 Published online: 15 January 2024 1649 1683 W4390898677.pdf 0 15 separator 0.9248157 ¶ 1683 1685 W4390898677.pdf 0 16 paratext 0.53555435 Check for updates 1686 1704 W4390898677.pdf 0 0 paratext 0.8163775 "Journal of Clinical Medicine" 0 30 W3112626654.pdf 0 1 separator 0.6125934 ¶ 30 32 W3112626654.pdf 0 2 title 0.79250085 Review 32 39 W3112626654.pdf 0 3 separator 0.7813306 ¶ 39 41 W3112626654.pdf 0 4 title 0.980536 "Systematic Review with Meta-Analysis: Endoscopic and Surgical Resection for Ampullary Lesions" 41 137 W3112626654.pdf 0 5 separator 0.9931929 ¶ 137 139 W3112626654.pdf 0 6 contact 0.885518 "Christian Heise1,y, Einas Abou Ali2,y , Dirk Hasenclever3, Francesco Auriemma4, Aiste Gulla5,6, Sara Regner7 , Sébastien Gaujoux8and Marcus Hollenbach9,*" 139 299 W3112626654.pdf 0 7 separator 0.9720737 ¶ 299 301 W3112626654.pdf 0 8 contact 0.99291444 "1Department of Medicine I—Gastroenterology, Pulmonology, Martin-Luther University Halle-Wittenberg, 06097 Halle, Germany; christian.heise@uk-halle.de" 301 453 W3112626654.pdf 0 9 separator 0.5339372 453 454 W3112626654.pdf 0 10 contact 0.9828907 "¶ 2Department of Gastroenterology, Digestive Oncology and Endoscopy, Cochin Hospital, Paris Descartes University, 75014 Paris, France; einas.abouali@gmail.com" 454 614 W3112626654.pdf 0 11 separator 0.59151644 ¶ 614 616 W3112626654.pdf 0 12 contact 0.99419045 "3Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, 04103 Leipzig, Germany; dirk.hasenclever@medizin.uni-leipzig.de" 616 778 W3112626654.pdf 0 13 separator 0.82708114 ¶ 778 780 W3112626654.pdf 0 14 contact 0.99374765 "4Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Hospital, Rozzano, 20089 Milan, Italy; francesco.auriemma.1987@gmail.com" 780 944 W3112626654.pdf 0 15 separator 0.71732 ¶ 944 946 W3112626654.pdf 0 16 contact 0.9932267 "5Department of Abdominal Surgery, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, 01513 Vilnius, Lithuania; aistegulla@gmail.com" 946 1102 W3112626654.pdf 0 17 separator 0.56852865 ¶ 1102 1104 W3112626654.pdf 0 18 contact 0.9841821 "6General Surgery, MedStar Georgetown University Hospital, Washington, DC 20007, USA 7Department of Clinical Sciences Malmö, Section for Surgery, Lund University, 221 00 Lund, Sweden; sara.regner@med.lu.se" 1104 1313 W3112626654.pdf 0 19 separator 0.83216304 ¶ 1313 1315 W3112626654.pdf 0 20 contact 0.99257237 "8Department of Pancreatic and Endocrine Surgery, Piti é-Salpetriere Hospital, M édecine Sorbonne Universit é, 75000 Paris, France; sebastien.gaujoux@aphp.fr" 1315 1474 W3112626654.pdf 0 21 separator 0.7658376 ¶ 1474 1476 W3112626654.pdf 0 22 contact 0.98558253 "9Medical Department II, Division of Gastroenterology, University of Leipzig Medical Center, 04103 Leipzig, Germany *Correspondence: marcus.hollenbach@medizin.uni-leipzig.de; Tel.: +49-34-1971-2362" 1476 1677 W3112626654.pdf 0 23 separator 0.9746748 ¶ 1677 1679 W3112626654.pdf 0 24 paratext 0.91029954 yAuthors contributed equally and shared first authorship. 1679 1736 W3112626654.pdf 0 25 separator 0.6287794 ¶ 1736 1738 W3112626654.pdf 0 26 paratext 0.9781214 "Received: 11 October 2020; Accepted: 30 October 2020; Published: 10 November 2020 /gid00030/gid00035/gid00032/gid00030/gid00038/gid00001/gid00033/gid00042/gid00045 /gid00001 /gid00048/gid00043/gid00031/gid00028/gid00047/gid00032/gid00046" 1738 1980 W3112626654.pdf 0 27 separator 0.9941634 ¶ 1980 1982 W3112626654.pdf 0 28 text 0.99635196 "Abstract: Ampullary lesions (ALs) can be treated by endoscopic (EA) or surgical ampullectomy (SA) or pancreaticoduodenectomy (PD). However, EA carries significant risk of incomplete resection while surgical interventions can lead to substantial morbidity. We performed a systematic review and meta-analysis for R0, adverse-events (AEs) and recurrence between EA, SA and PD. Electronic databases were searched from 1990 to 2018. Outcomes were calculated as pooled means using fixed and random-e ects models and the Freeman-Tukey-Double-Arcsine-Proportion-model. We identified 59 independent studies. The pooled R0 rate was 76.6% (71.8–81.4%, I2=91.38%) for EA, 96.4% (93.6–99.2%, I2=37.8%) for SA and 98.9% (98.0–99.7%, I2=0%) for PD. AEs were 24.7% (19.8–29.6%, I2=86.4%), 28.3% (19.0–37.7%, I2=76.8%) and 44.7% (37.9–51.4%, I2=0%), respectively." 1982 2843 W3112626654.pdf 0 29 separator 0.63525414 ¶ 2843 2845 W3112626654.pdf 0 30 text 0.99931777 "Recurrences were registered in 13.0% (10.2–15.6%, I2=91.3%), 9.4% (4.8–14%, I2=57.3% ) and 14.2% (9.5–18.9%, I2=0%). Dierences between proportions were significant in R0 for EA compared to SA (p=0.007) and PD ( p=0.022). AEs were statistically di erent only between EA and PD ( p=0.049) and recurrence showed no significance for EA /SA or EA /PD. Our data indicate an increased rate of complete resection in surgical interventions accompanied with a higher risk of complications. However, studies showed various sources of bias, limited quality of data and a significant heterogeneity, particularly in EA studies." 2845 3470 W3112626654.pdf 0 31 separator 0.9874011 ¶ 3470 3472 W3112626654.pdf 0 32 text 0.49102664 Keywords: ampullectomy; papillectomy 3472 3509 W3112626654.pdf 0 33 table 0.3744392 ; 3509 3510 W3112626654.pdf 0 34 text 0.40055096 pancreaticoduo 3510 3525 W3112626654.pdf 0 35 table 0.3795451 denectomy; 3525 3535 W3112626654.pdf 0 36 text 0.46921036 trans-duodenal am 3535 3553 W3112626654.pdf 0 37 table 0.34347022 pullectomy 3553 3563 W3112626654.pdf 0 38 text 0.39556918 "; ampulla of Vater" 3563 3583 W3112626654.pdf 0 39 separator 0.97787106 ¶ 3583 3585 W3112626654.pdf 0 40 paratext 0.98384094 J. Clin. Med. 2020 ,9, 3622; doi:10.3390 /jcm9113622 www.mdpi.com /journal /jcm 3585 3665 W3112626654.pdf 0 0 paratext 0.5457428 A GEó 0 5 W2742651804.pdf 0 1 title 0.58966243 GRAFA ISABEL ANDRÉ 5 24 W2742651804.pdf 0 2 separator 0.4754653 ¶ 24 26 W2742651804.pdf 0 3 title 0.9209606 "NOTAS DE TESTEMUNHO DE UM PERCURSO INOVADOR, BRILHANTE E LIVREi" 26 92 W2742651804.pdf 0 4 separator 0.9263941 ¶ 92 94 W2742651804.pdf 0 5 contact 0.8826585 "Patrícia Pedro r êgo1 se" 94 121 W2742651804.pdf 0 6 text 0.54735935 "eu tiver que morrer Vou morr" 121 153 W2742651804.pdf 0 7 contact 0.47625643 er pela 153 160 W2742651804.pdf 0 8 text 0.44671747 vida 160 165 W2742651804.pdf 0 9 contact 0.84496236 "! Vinicius de Moraes" 165 187 W2742651804.pdf 0 10 separator 0.97879195 ¶ 187 189 W2742651804.pdf 0 11 text 0.991935 "isabel a ndré faz parte da geração entusiasta que chegou ao Departamento de Geografia da faculdade de Letras da Universidade de Lisboa, no imediato pós -25 de a bril de 74. espírito brilhante, vivo, confiante e amante dos debates, impôs os seus pontos de vista e interessou -se geograficamente pelas novas temáticas sociais que o contexto revolucionário fazia chegar à a cademia nesses anos de formação." 189 604 W2742651804.pdf 0 12 separator 0.9399124 ¶ 604 606 W2742651804.pdf 0 13 text 0.9996478 "Pioneira em muitas iniciativas e decisões, desde logo na maternidade que abraçou no limiar da idade adulta, antes ainda de chegar à Universidade, i sabel a ndré associava a paixão à racionalidade numa medida desconhecida para a maioria dos seus contemporâneos. exemplo da harmonização sur - preendente entre um pensamento racional de que não abdicava (dizia, com frequência, “vou pensar no assunto... ”) e o entusiasmo, a paixão, perante cada nova descoberta (os novos conceitos, as interacções que se evidenciavam, os actores em presença, o papel dos lugares...), a sua forma de viver traduziu -se na afirmação da integridade, evidenciada no seu percurso pessoal e profissional, e expressa num exercício constante de liberdade. Havia na i sabel a ndré a generosidade da partilha das suas experiências e dos seus projectos com os outros, convocando -os para o seu círculo próximo, numa medida maravilhosa, didáctica e incentivadora, embora adepta da autonomia de cada uma e de cada um. a sua vivência inte-gradora, particularmente atenta aos mais jovens, beneficiou os seus alunos, os discípulos, a família, os amigos. era, contudo, exigente porque queria construir um caminho novo." 606 1808 W2742651804.pdf 0 14 separator 0.98892546 ¶ 1808 1810 W2742651804.pdf 0 15 text 0.99951655 "Desde muito cedo (finais dos anos 70) i sabel a ndré colaborou na investigação, no Centro de e stu- dos Geográficos, na linha de acção estudos para o Planeamento regional e Urbano. a economia e a política sempre a interessaram e, para além do contributo em projectos de planeamento, colaborou nos estudos pioneiros na temática da Geografia e leitoral a que dedicou, aliás, a sua tese de mestrado em 1984." 1810 2223 W2742651804.pdf 0 16 separator 0.9960754 ¶ 2224 2226 W2742651804.pdf 0 17 contact 0.99456596 "1 Professora a uxiliar, Departamento de Geociências, Universidade de Évora, Colégio Luís a ntónio Verney, r ua r omão ramalho, 59, 7000 -671 Évora, Portugal. e -mail: patrego@uevora.pt" 2226 2414 W2742651804.pdf 0 18 paratext 0.961541 "Finisterra , LII, 105, 2017, pp. 143 ‐145 doi: 10.18055/finis12208" 2414 2483 W2742651804.pdf 0 19 separator 0.4907018 2483 2484 W2742651804.pdf 0 20 paratext 0.770051 ¶ Comentário 2484 2496 W2742651804.pdf 0 21 separator 0.99516845 ¶ 2496 2498 W2742651804.pdf 0 0 bibliography 0.99391353 "6. S. Konasová, The benefits of vegetated roofs in reducing the excess heat in three urban areas with different climate conditions. Advances and Trends in Engineering Sciences and Technologies III - Proceedings of the 3rd International Conference on Engineering Sciences an d Technologies, ESaT 2018; 2019." 0 315 W4388025809.pdf 7 1 separator 0.9854168 ¶ 317 319 W4388025809.pdf 7 2 bibliography 0.99693877 "7. K. Nečadová, P. Selník, H. Karafiátová, Differential substrate subsidence of the EnviHUT project pitched extensive green roof. MATEC Web of Conferences; 2016." 319 484 W4388025809.pdf 7 3 separator 0.8669369 "¶ ¶ ¶" 486 501 W4388025809.pdf 7 4 paratext 0.9435921 8 501 503 W4388025809.pdf 7 5 separator 0.96382177 ¶ 503 505 W4388025809.pdf 7 6 paratext 0.9819055 MATEC Web of Conferences 385, 01036 (2023) https://doi.org/10.1051/matecconf/202338501036 505 596 W4388025809.pdf 7 7 separator 0.752179 ¶ 596 598 W4388025809.pdf 7 8 paratext 0.97447085 Young Scientist 2023 598 619 W4388025809.pdf 7 0 paratext 0.9783012 "Arts and Design Studies www.iiste.org ISSN 2224-6061 (Paper) ISSN 2225-059X (Online) Vol.92, 2021 ¶ 15" 0 278 W3157861315.pdf 4 1 separator 0.97187364 ¶ 279 281 W3157861315.pdf 4 2 title 0.99361455 3.4 Visual Art of Indung in Sundanese Myth 281 324 W3157861315.pdf 4 3 separator 0.99570227 ¶ 325 327 W3157861315.pdf 4 4 text 0.9969594 "Indung artwork in Sundanese mythological figures is an ar twork made based on research. Research was carried out on the existence of two indung figures namely Sunan Ambu contained in mythology o r religious beliefs Kanekes Baduy Dalam and Dewi Sri or Nyi Sri Pohaci contained in the ancient manuscript Ksatriya Budug Basu." 327 658 W3157861315.pdf 4 5 separator 0.7799232 ¶ 659 661 W3157861315.pdf 4 6 text 0.9996187 "The work consists of two works, Indung of Aing and Nyi Sri Pohaci: Indung Pare. The concept is based o n the results of research, namely data collection through literature." 661 838 W3157861315.pdf 4 7 separator 0.9971106 ¶ 839 841 W3157861315.pdf 4 8 title 0.99328 3.4.1 Artwork : Indung of Aing 841 872 W3157861315.pdf 4 9 separator 0.99590003 ¶ 873 875 W3157861315.pdf 4 10 text 0.9997441 "Indung of Aing concept is based on the results of l iterature, Saputra (Heryana, 2006) writes, in the b elief of urang Kanekes, there is called Ambu Langit that is the woman who will assign Aing (human who is still in the womb) to descend into the world. By Ambu Langit, th e Aing was handed over to Ambu Tengah named Nyi Randakasih. From Ambu tengah then descended again t o Ambu Bumi named Ambu Dayang Wirati. Here Si Aing meets Ambu Dayang Wirati and receives love. So by t he intercession of love and love of a mother and a father called Indung Simbarang Kandung (mother) and Bapa Simbarang Jadikeun (father), Si Aing human in the belly of Indung Simbarang Kandung. After nine months Si Aing spoke to Ambu for permission to travel in Buana Pancatengah (earth)." 875 1669 W3157861315.pdf 4 11 separator 0.9792719 ¶ 1670 1672 W3157861315.pdf 4 12 text 0.9997069 "The literature is interpreted in visual artwork wit h depictions of Ambu Langit (mother of sky), Ambu Tengah (mother of middle) and Ambu Bumi (mother of earth) as bird and buterflies. Birds and buterfly a re used as symbols of Goddesses. The indung are not depicted, the Aing as a human candidate is described as a fish that is in the womb of the Indung Simbarang Kandung (mother)." 1672 2067 W3157861315.pdf 4 13 separator 0.97573566 ¶ 2068 2070 W3157861315.pdf 4 14 text 0.9997059 "The visual style used batik tulis technique with ba tik pesisir motifs. Such as mega mendung, daun taleus , kumeli , and others. The use of color in this work follows the colors on batik pesisir, such as blue, purple, pink, yellow, orange and others that give a festive impre ssion. Batik pesisir is a batik produced by batik c raftman from the lower society. Decorative and color is richer b ecause it gets influence from Chinese and Indo-Dutc h culture, batik pesisir area that is the north coast of Java Island such as Indramayu, Cirebon, Tegal, Pekalonga n, and others (Hasanudin 2001)." 2070 2679 W3157861315.pdf 4 15 separator 0.97730917 ¶ 2681 2683 W3157861315.pdf 4 16 text 0.99904186 "The work (as seen on figure 2) is made with batik t ulis technique, using cold wax media from tamarine powder, this is a new batik technique that is popul ar in Indonesia today. Coloring using textile paint , fabric using polyester cloth with a size of 50 x 150 cm." 2683 2955 W3157861315.pdf 4 17 separator 0.91247845 ¶ 2956 2961 W3157861315.pdf 4 18 math 0.67105675 "¶ ¶ ¶ ¶ ¶ ¶ ¶ (a) ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ (b)" 2961 3113 W3157861315.pdf 4 19 separator 0.99315214 ¶ 3114 3116 W3157861315.pdf 4 20 caption 0.9953718 "Figure 2. Indung of Aing, (a) The upper part of the artwork, (b) The bottom part of the artwork, measures 50x150 cm." 3116 3238 W3157861315.pdf 4 21 separator 0.94809014 ¶ 3240 3242 W3157861315.pdf 4 22 caption 0.5093387 Source: https://www.artpal.com/rinimaulina and http 3242 3294 W3157861315.pdf 4 23 bibliography 0.44615602 3294 3295 W3157861315.pdf 4 24 caption 0.53264046 s://www.youtube.com/watch?v= 3295 3323 W3157861315.pdf 4 25 bibliography 0.29410174 CWtuHxj6v 3323 3332 W3157861315.pdf 4 26 caption 0.36658636 3w 3332 3334 W3157861315.pdf 4 27 separator 0.99533916 ¶ 3336 3338 W3157861315.pdf 4 28 title 0.9931851 3.4.2 Artwork: Nyi Sri Pohaci: Indung Pare 3338 3381 W3157861315.pdf 4 29 separator 0.9949268 ¶ 3382 3384 W3157861315.pdf 4 30 text 0.99947226 "Nyi Sri Pohaci: Indung Pare concept is based on the results of literature, based on the ancient manusc ript Serat Satriya Budug Basu written by Pangeran Sujatmaningr at (Ridwan and Abdulgani, 2012). In the ancient manuscript, there is a story about Budug Basu and N yi Sri Pohaci (Dewi Sri). In Budug Basu's story, th e characters are played by Gods, giants and humans (p easants). The setting of the story is mostly in Kah yangan, the world where the Gods live. The story contains o f part of people's lives, namely agriculture, such as the origin of rice crops, irrigation, pests and others. In add ition, there is a story as a public belief in the r ice Goddess Dewi Sri as the origin of rice and Budug Basu as the ori gin of fish in the sea (Ridwan and Abdulgani 2012)." 3384 4177 W3157861315.pdf 4 31 separator 0.9148444 ¶ 4180 4182 W3157861315.pdf 4 32 text 0.99935496 "In the manuscript of serat Satriya Budug Basu, the origin of rice is come from the body of Nyi Sri Poh aci (Dewi Sri). According to Lombard, myths with such m otives exist throughout the archipelago, including islands" 4182 4403 W3157861315.pdf 4 33 separator 0.9945642 ¶ 4404 4406 W3157861315.pdf 4 0 paratext 0.9852579 E2056 Wang et al. 0 19 W2009309312.pdf 6 1 separator 0.9339955 "¶ ¶" 21 31 W2009309312.pdf 6 2 caption 0.9966404 "Figure 2. Biophysical characterization of the effect of th e p.Ser129Arg mutation on the structures of both βB1-crystallin homomer and βB1/βA3-crystallin heteromer. The samples were prepar ed by dissolving the proteins in buffer B. The βB1/βA3- crystallin was prepared by incubating equimolar of βB1-crystallin and βA3-crystallin at 37 °C for 2 h. (A) Far-UV CD. (B)" 31 404 W2009309312.pdf 6 3 separator 0.93796384 ¶ 405 407 W2009309312.pdf 6 4 caption 0.9723349 "Intrinsic fluorescence. In panels (A) and (B), the difference spectra were produced by subtracting the sum spectra of the homomers by that of equimola r heteromer. (C) Parameter A. Parameter A was calculated by dividi ng the fluorescence intensity at 320 nm ( I 320) to that at 365 nm ( I365). (D) Extrinsic ANS fluorescence. (E) SEC analysis. The arrow heads along the top axis indicate the elution posit ions of the standard molecular weight markers of 66 kDa, 29 kDa and 14 kDa, from left to right, respectively. The inset shows the identification of the heteromer by SDS-PAGE of the eluted samples. M, 1, 2 and 3 represents the marker, purified βA3-crystallin, purified βB1-crystallin and the eluted samples of the heteromer collected from the main peak in the SEC profile, respectively. The void volume of Supe rdex 75 HR 10/30 column is 8 ml. (F) Crystal structure of the truncated βB1-crystallin (PDB 1OKI) (Van Montfort, et al., 2003). The position of Ser129 was highlighted by the space-filling model." 407 1443 W2009309312.pdf 6 5 separator 0.99396473 ¶ ¶ 1444 1450 W2009309312.pdf 6 6 title 0.9892246 DISCUSSION 1450 1461 W2009309312.pdf 6 7 separator 0.990098 ¶ ¶ 1462 1468 W2009309312.pdf 6 8 text 0.99967504 "In this study, we have identified a novel causative mutation p.Ser129Arg in CRYBB1 in a large Chinese family with CCMC. βB1-crystallin is a major subunit of the β-crystallins and comprises 9% of the total soluble crystallin in the human lens (Lampi, et al., 1997). The three-dimensional X-ray structure of βB1-crystallin shows it contains two tightly folded domains, N-terminal and C-termin al domains, composed of two Greek key motifs(Van Montfort, et al., 2003). The mutation det ected in this family is located in ex on 4, which encode s the Greek key II, and replaces the polar uncharged serine by the charged resi due arginine at position 129. As suggested by Polyphen analysis, the mutation is predicted to be possibly damaging, which highlights the functional importance of this region of βB1-crystallin. To our knowledge, this is the first re port of causative mutations identified in Greek key II of βB1-crystallin associated with CCMC." 1468 2439 W2009309312.pdf 6 9 separator 0.9752218 ¶ ¶ 2441 2447 W2009309312.pdf 6 0 paratext 0.9868171 Contemporary Clinical Trials 127 (2023) 107122 0 46 W4321378662.pdf 4 1 separator 0.59677136 ¶ 46 48 W4321378662.pdf 4 2 paratext 0.9810813 4 48 50 W4321378662.pdf 4 3 separator 0.9946941 ¶ 50 52 W4321378662.pdf 4 4 caption 0.98931277 Fig. 1.Flowchart diagram: an overview the RCT study design. 52 112 W4321378662.pdf 4 5 separator 0.9934067 ¶ 113 115 W4321378662.pdf 4 6 table 0.646238 Abbreviations. GP: General practitioner; ASRD: Anxiety and stress-related disorders; AUDIT: Alcohol Use Disorders Identification Test; DUDIT: Drugs Use Disorders 115 277 W4321378662.pdf 4 7 separator 0.80653834 ¶ 278 280 W4321378662.pdf 4 8 bibliography 0.41240597 Identification Test; 280 301 W4321378662.pdf 4 9 table 0.34280407 EEG: 301 306 W4321378662.pdf 4 10 text 0.33311498 Electro 306 314 W4321378662.pdf 4 11 bibliography 0.32606423 encephal 314 322 W4321378662.pdf 4 12 text 0.32817712 ography 322 329 W4321378662.pdf 4 13 bibliography 0.3633539 ; 329 331 W4321378662.pdf 4 14 table 0.3959562 iCBT 331 335 W4321378662.pdf 4 15 bibliography 0.54495806 -I: internet-based Guided Cognitive Behavioral Therapy for Insomnia; ISI: Insomnia Severity Index; MHC: 335 438 W4321378662.pdf 4 16 separator 0.71724033 ¶ 439 441 W4321378662.pdf 4 17 bibliography 0.52913535 Mental health care; 441 461 W4321378662.pdf 4 18 text 0.32311186 M 461 463 W4321378662.pdf 4 19 bibliography 0.66530395 .I.N.I: Mini International Neuropsychiatric Interview; OCD: Obsessive compulsive disorder; RMT20: Rapid Measurement-Toolkit 20. J.E. Reesen et al. 463 609 W4321378662.pdf 4 0 paratext 0.9302364 "Multi-Dimensional Implication of Water Scarcity on Inhabitants of District Quetta, 69 Balochistan, Pakistan" 0 110 W3037504323.pdf 10 1 separator 0.9194467 ¶ ¶ 112 118 W3037504323.pdf 10 2 text 0.9875193 "immediately withdraw subsidy on irrigation tube wells, and shift existing irrigation on efficient irrigation to minimize the use of water consumption." 118 272 W3037504323.pdf 10 3 separator 0.6572534 ¶ 274 276 W3037504323.pdf 10 4 text 0.9857706 "2. All existing tube wells in Quetta valley needed to be registered. Also phase wise closing down of illegal tube wells with provision of piped water to each and every house to full filled their domestic need. 3. Restrictions be made on use of sweet water for agriculture, in case of violation, Imposition of heavy fines for water extravagance or theft." 276 643 W3037504323.pdf 10 5 separator 0.50973326 ¶ 644 646 W3037504323.pdf 10 6 text 0.99634457 "4. Autonomous & Empowered ‘Water Body’ be set up to oversee all water sector projects. Community and water managers must in liaison to control the situation." 646 810 W3037504323.pdf 10 7 separator 0.5390011 ¶ 811 813 W3037504323.pdf 10 8 text 0.9855595 "5. Conservation & Efficient Use of Water be made part of school curriculums. Periodic Water Awareness Drives be run on the lines of Polio Campaigns Optimizing. 6. Strategic plantation and effective control over new housing schemes in Quetta valley be made to overcome the issue." 813 1104 W3037504323.pdf 10 9 separator 0.9909462 ¶ ¶ 1106 1112 W3037504323.pdf 10 10 title 0.7901474 References 1112 1123 W3037504323.pdf 10 11 separator 0.92356443 ¶ ¶ 1124 1130 W3037504323.pdf 10 12 bibliography 0.99764156 "Ahmed, Sheikh (2015). Quetta Water And Sanitation Authroity Performance and Prospects, (An organizational Study), QWASA publication, Quetta, p. 4." 1130 1280 W3037504323.pdf 10 13 separator 0.6705106 ¶ 1282 1284 W3037504323.pdf 10 14 bibliography 0.49621013 1286 1287 W3037504323.pdf 10 15 separator 0.62324667 ¶ 1287 1288 W3037504323.pdf 10 16 bibliography 0.9964838 "Ali, Wajid and Kakar, Azizullah (2018, April 13). Balochistan’s water, Dawn. Retrieved from https://www.dawn.com on October 24, 2018." 1288 1425 W3037504323.pdf 10 17 separator 0.77239674 ¶ ¶ 1427 1433 W3037504323.pdf 10 18 bibliography 0.9980474 "Anam, A. &Shafique, M. (2017). Agriculture in Pakistan and its Impact on Economy – A Review. International Journal of Advanced Science and Technology. Vol,103pp, 47-60." 1433 1608 W3037504323.pdf 10 19 separator 0.6681998 ¶ ¶ 1610 1616 W3037504323.pdf 10 20 bibliography 0.9980214 "Arkin, H, & Colton, R. (1963). Table for the statistics. New York: Barnes and Noble Publication." 1616 1716 W3037504323.pdf 10 21 separator 0.61037683 ¶ ¶ 1719 1725 W3037504323.pdf 10 22 bibliography 0.9973556 "Asian Development Bank. (2002). Report on Poverty in Pakistan, Issues, Causes and Institutional responses.https://www.adb.org/sites/default/files/institutional- document/33464/files/poverty.pdf" 1725 1927 W3037504323.pdf 10 23 separator 0.89768946 ¶ ¶ 1928 1934 W3037504323.pdf 10 24 bibliography 0.9975072 "Bajoi AH. (2004). Report on reorganization of Agriculture Research and Extension Balochistan University of Information TechnologyEngineeringand Management Sciences Quetta." 1934 2115 W3037504323.pdf 10 25 separator 0.6717046 ¶ ¶ 2116 2122 W3037504323.pdf 10 26 bibliography 0.9978926 "Bhatti SS, Khattak MUK, &Roohi R. (2008). Planning Water Resource Management in Pishin Lora River Basin of Balochistan Using GIS/RS Techniques. Proceeding of ICAST.(2): 91-97." 2122 2306 W3037504323.pdf 10 27 separator 0.99091196 ¶ 2307 2309 W3037504323.pdf 10 0 paratext 0.9900231 NEW BOOKS I 767 0 15 W2326196713.pdf 0 1 separator 0.9828799 ¶ 16 18 W2326196713.pdf 0 2 title 0.4033493 3. 18 21 W2326196713.pdf 0 3 separator 0.3457396 ¶ 22 24 W2326196713.pdf 0 4 text 0.4476785 4. 24 27 W2326196713.pdf 0 5 separator 0.46654004 ¶ 28 30 W2326196713.pdf 0 6 text 0.8078237 5. In some cases notable quantities of nitrates remain in the mature 30 101 W2326196713.pdf 0 7 separator 0.49316514 ¶ 101 102 W2326196713.pdf 0 8 text 0.9719874 The amounts of nitrates found in vegetables are of the same order 102 168 W2326196713.pdf 0 9 separator 0.6902789 ¶ 169 171 W2326196713.pdf 0 10 text 0.9913569 "A person on a diet consisting of fresh vegetables, wholly or largely plant : instance ripe beets and turnips. but rather more in many instances than those found in cured meats. would consume more nitrates than one on a mixed diet consisting in part of cured meats. As much as the equivalent of from one to two grams of saltpeter daily could be consumed by a person eating fresh vegetables. Inasmuch as a fresh vegetable diet is entirely harmless and as no case of injury from saltpeter in cured meats is on record, saltpeter in the quantities used in cured meats must be classed as a harmless substance. 6." 171 802 W2326196713.pdf 0 11 separator 0.9398902 ¶ 803 805 W2326196713.pdf 0 12 contact 0.7478022 7. 805 808 W2326196713.pdf 0 13 separator 0.8417312 ¶ 809 811 W2326196713.pdf 0 14 contact 0.94140404 "CHEMICAL LABORATORY OF SWIFT AND Co. Chicago, Ill." 811 865 W2326196713.pdf 0 15 separator 0.9876878 ¶ 866 868 W2326196713.pdf 0 16 title 0.79191 CORRECTION. 868 880 W2326196713.pdf 0 17 separator 0.98659647 ¶ 881 883 W2326196713.pdf 0 18 text 0.99232066 "On page 573, lines 5, 6 and 7, of the current volume of the Journal, is found the sentence, ‘‘ 3 cc. of nitric oxide gas mixed with three liters of air will efficiently bleach a kilo of flour.’’ In writing the sentence, I intended to use the word distinctly ” instead of ‘‘ efficiently,” just as I did in the parallel experiment with bromine vapor given at the bottom of the preceding page. S. AVERY." 883 1299 W2326196713.pdf 0 19 separator 0.9920646 ¶ 1300 1302 W2326196713.pdf 0 20 title 0.9626171 NEW BOOKS. 1302 1313 W2326196713.pdf 0 21 separator 0.7619263 ¶ 1314 1316 W2326196713.pdf 0 22 title 0.9582539 "THE ELEMENTS OF PHYSICAL CHEMISTRY. BY HARRY C. JONES. Third Edition, Revised and Enlarged. Price &, net." 1316 1425 W2326196713.pdf 0 23 separator 0.9908612 ¶ 1426 1428 W2326196713.pdf 0 24 text 0.99537367 "The new edition of this excellent and well known work has been care- fully revised. Of the abundant and important material published since the appearance, five years since, of the earlier edition, whatever was fairly within the scope of the book has been incorporated in it, with the result that it has been enlarged by about a seventh part. A goodly num- ber of references to original papers will enable the student to follow a given discussion further than the limits of the text. Naturally, the chapters on Solutions and on Electrochemistry contain the most of the new material, but half df the other chapters show additions. The new edition well deserves the same commendation and the same welcome as that with which the earlier one was received. New York, The MacMillan Company, 1907." 1428 2248 W2326196713.pdf 0 25 separator 0.99525374 ¶ 2249 2251 W2326196713.pdf 0 26 title 0.6762409 EDWARD W. MORLEY. 2251 2269 W2326196713.pdf 0 27 separator 0.9490137 ¶ 2270 2272 W2326196713.pdf 0 28 title 0.93969667 ENTWICKELUNGSGBSCKICHTB DER CHEMIE. VON A. LADENBURG. 2272 2326 W2326196713.pdf 0 29 contact 0.793902 Braunschweig, 2326 2340 W2326196713.pdf 0 30 separator 0.7973628 ¶ 2341 2343 W2326196713.pdf 0 31 contact 0.5998192 Friederich Vieweg und Sohn, 1907 2343 2376 W2326196713.pdf 0 32 text 0.54355603 . 2376 2377 W2326196713.pdf 0 33 separator 0.95299214 ¶ 2378 2380 W2326196713.pdf 0 34 text 0.99805415 "Ladenburg’s “Entwickelungsgeschichte der Chemie” is an attempt to trace the development of our present conceptions of chemistry from earlier conceptions, beginning with the time of Lavoisier. By omitting bio- Price, unbound, IZ marks." 2380 2621 W2326196713.pdf 0 0 separator 0.92474854 ¶ 1 2 W3124786751.pdf 13 1 paratext 0.54899937 13 2 5 W3124786751.pdf 13 2 separator 0.723802 ¶ 6 8 W3124786751.pdf 13 3 bibliography 0.9905299 "in Prostate Cancer: Progesterone receptor B is the isoform associated with dis ease progression, 1 Sci Rep 8(1) (2018) 11358. 2 [24] C.M. Luetjens, A. Didolkar, S. Kliesch, W. Paulus, A. Jeibmann, W. Bocker, E. Nieschlag, 3 M. Simoni, Tissue expression of the nuclear progesterone receptor in male non -human primates 4 and men, J Endocrinol 18 9(3) (2006) 529 -39. 5 [25] D. Crews, Evolution of neuroendocrine mechanisms that regulate sexual behavior, Trends 6 Endocrinol Metab 16(8) (2005) 354 -61. 7 [26] C.K. Wagner, The many faces of progesterone: a role in adult and developing male brain, 8 Front Neuroen docrinol 27(3) (2006) 340 -59. 9 [27] J.W. Funder, Mineralocorticoid receptor activation and specificity -conferring mechanisms: 10 a brief history, Journal of Endocrinology 234(1) (2017) T17 -T21. 11 [28] B.C. Rossier, M.E. Baker, R.A. Studer, Epithelial sodium tran sport and its control by 12 aldosterone: the story of our internal environment revisited, Physiological reviews 95(1) (2015) 13 297-340. 14 [29] P.J. Fuller, Y. Yao, J. Yang, M.J. Young, Mechanisms of ligand specificity of the 15 mineralocorticoid receptor, J Endocrin ol 213(1) (2012) 15 -24. 16 [30] R.P. Lifton, A.G. Gharavi, D.S. Geller, Molecular mechanisms of human hypertension, Cell 17 104(4) (2001) 545 -56. 18 [31] I. Hanukoglu, A. Hanukoglu, Epithelial sodium channel (ENaC) family: Phylogeny, 19 structure -function, tissue dist ribution, and associated inherited diseases, Gene 579(2) (2016) 95 - 20 132. 21 [32] S. Shibata, 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid 22 receptor and NaCl transport mechanisms in the renal distal nephron, J Endocrinol 234(1) (2017) 23 T35-T47. 24 [33] U.A. Hawkins, E.P. Gomez -Sanchez, C.M. Gomez -Sanchez, C.E. Gomez -Sanchez, The 25 ubiquitous mineralocorticoid receptor: clinical implications, Curr Hypertens Rep 14(6) (2012) 26 573-80. 27 [34] L. Martinerie, M. Munier, D. Le Menuet, G. Meduri, S. Viengchareun, M. Lombes, The 28 mineralocorticoid signaling pathway throughout development: expression, regulation and 29 pathophysiological implications, Biochimie 95(2) (2013) 148 -57. 30 [35] A. Odermatt, D.V. Kratschmar, Tissue -specific modulation of mineralocorticoid recept or 31 function by 11beta -hydroxysteroid dehydrogenases: an overview, Molecular and cellular 32 endocrinology 350(2) (2012) 168 -86. 33 [36] M.E. Baker, Y. Katsu, 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: 34 Evolution of the mineralocorticoid receptor: sequence, struc ture and function, J Endocrinol 35 234(1) (2017) T1 -T16. 36 [37] J.W. Funder, Reconsidering the roles of the mineralocorticoid receptor, Hypertension 53(2) 37 (2009) 286 -90. 38 [38] F. Jaisser, N. Farman, Emerging Roles of the Mineralocorticoid Receptor in Pathology: 39 Toward New Paradigms in Clinical Pharmacology, Pharmacological reviews 68(1) (2016) 49 -75. 40 [39] J.J. DuPont, I.Z. Jaffe, 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The 41 role of the mineralocorticoid receptor in the vasculature, J Endocrinol 234(1) (2017) T 67-T82. 42 [40] E.P. Gomez -Sanchez, Mineralocorticoid receptors in the brain and cardiovascular 43 regulation: minority rule?, Trends Endocrinol Metab 22(5) (2011) 179 -87. 44 [41] M. Joels, E.R. de Kloet, 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: The 45 brain minera locorticoid receptor: a saga in three episodes, J Endocrinol 234(1) (2017) T49 -T66." 9 3540 W3124786751.pdf 13 4 paratext 0.9839879 46 Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 21 January 2020 doi:10.20944/preprints202001.0231.v1 3540 3680 W3124786751.pdf 13 0 title 0.8680544 CORRIGENDUM 0 11 W4235863277.pdf 0 1 separator 0.99139106 ¶ 11 13 W4235863277.pdf 0 2 title 0.9228097 Integration Processes of Syrian Refugees in Turkey: ‘Class-based Integration’ 13 91 W4235863277.pdf 0 3 separator 0.66392505 ¶ 91 93 W4235863277.pdf 0 4 paratext 0.54475385 DOG ̆US/ 93 102 W4235863277.pdf 0 5 text 0.47552103 C176 102 106 W4235863277.pdf 0 6 paratext 0.45401028 S/C 106 109 W4235863277.pdf 0 7 text 0.42264652 176 109 112 W4235863277.pdf 0 8 paratext 0.54276097 _IMS/C176EK 112 123 W4235863277.pdf 0 9 separator 0.34491134 123 124 W4235863277.pdf 0 10 paratext 0.6722841 ¶ Journal of Refugee Studies . doi:10.1093/jrs/fey057. 124 178 W4235863277.pdf 0 11 separator 0.9844681 ¶ 178 180 W4235863277.pdf 0 12 text 0.91895765 "The above article has been corrected to add the following reference which was omitted in error:" 180 278 W4235863277.pdf 0 13 separator 0.99339664 ¶ 278 280 W4235863277.pdf 0 14 bibliography 0.99570143 "AKCAPAR-KOSER, S. and SIMSEK, D. (2018) ‘The Politics of Syrian Refugees in Turkey: A Question of Inclusion and Exclusion throughCitizenship’. Social Inclusion 6(1): 176–187." 280 457 W4235863277.pdf 0 15 separator 0.9823872 ¶ 457 459 W4235863277.pdf 0 16 paratext 0.9430238 The author apologizes for the error.Journal of Refugee Studies Vol. 34, No. 1 /C223The Author(s) 2019. Published by Oxford University Press. 459 600 W4235863277.pdf 0 17 separator 0.8492212 ¶ 600 602 W4235863277.pdf 0 18 paratext 0.9166719 "All rights reserved. For permissions, please email: journals.permissions@oup.com doi:10.1093/jrs/fez014 Advance Access publication 7 February 2019Downloaded from https://academic.oup.com/jrs/article/34/1/1274/5310006 by guest on 18 May 2024" 602 845 W4235863277.pdf 0 19 separator 0.99674785 ¶ 845 847 W4235863277.pdf 0 0 paratext 0.85260016 Nedeva et al. OSCAR Signaling in Osteoclastogenesis 0 51 W3154071403.pdf 2 1 separator 0.9967537 ¶ 51 53 W3154071403.pdf 2 2 caption 0.60424453 TABLE 1 | Summary of 53 74 W3154071403.pdf 2 3 title 0.39293426 74 75 W3154071403.pdf 2 4 caption 0.42155606 s 75 76 W3154071403.pdf 2 5 title 0.4219801 keleton-related phenotypes 76 102 W3154071403.pdf 2 6 caption 0.55132234 in 102 105 W3154071403.pdf 2 7 title 0.4314732 knockout mice 105 119 W3154071403.pdf 2 8 caption 0.4766494 fo 119 122 W3154071403.pdf 2 9 title 0.47052878 r 122 124 W3154071403.pdf 2 10 caption 0.5347789 genes involved in osteoc 124 149 W3154071403.pdf 2 11 title 0.4569996 last 149 153 W3154071403.pdf 2 12 caption 0.7297887 differentiation in the order in which they are discussed in the text. 153 223 W3154071403.pdf 2 13 separator 0.9953145 ¶ 223 225 W3154071403.pdf 2 14 table 0.8888599 Gene Protein Skeleton-related phenotypes and diseases MGI IDs References 225 298 W3154071403.pdf 2 15 separator 0.7379325 298 299 W3154071403.pdf 2 16 table 0.976646 "¶ Csf1 M-CSF Osteopetrosis, op/op mouse Abnormal bone structure, morphology and remodeling Abnormal bone and dentin mineralisation Decreased bone resorption Abnormal osteoblast morphology and differentiation Abnormal osteoclast morphology and differentiation Decreased osteoclast cell number1856333 " 299 612 W3154071403.pdf 2 17 bibliography 0.9822394 "5305707Yoshida et al., 1990; Naito et al., 1991, 1997; Begg et al., 1993; Harris et al., 2012; Nakamichi et al., 2013" 612 733 W3154071403.pdf 2 18 separator 0.9796251 ¶ 733 735 W3154071403.pdf 2 19 table 0.9791856 "Csf1r M-CSFR Osteopetrosis Abnormal bone structure, morphology, physiology and mineralisation Failure of bone resorption Abnormal osteoblast morphology Abnormal osteoclast morphology and differentiation2181194" 735 955 W3154071403.pdf 2 20 bibliography 0.9953616 "Dai et al., 2002, 2004; Nakamichi et al., 2013" 955 1004 W3154071403.pdf 2 21 separator 0.86701155 ¶ 1004 1006 W3154071403.pdf 2 22 table 0.9290453 "Spi1 PU.1 Osteopetrosis Failure of tooth eruption3717917" 1006 1065 W3154071403.pdf 2 23 bibliography 0.99305797 Tondravi et al., 1997; Houston et al., 2007 1065 1109 W3154071403.pdf 2 24 separator 0.9274173 ¶ 1109 1111 W3154071403.pdf 2 25 table 0.9856853 "Mitf MITF Osteopetrosis, mi/mi mouse Osteosclerosis Abnormal bone morphology Failure of tooth eruption Abnormal osteoclast morphology and physiology1856087 ¶" 1111 1277 W3154071403.pdf 2 26 bibliography 0.99541503 "1856085Hodgkinson et al., 1993; Nii et al., 1995; McGill et al., 2002; Steingrimsson et al., 2002" 1277 1379 W3154071403.pdf 2 27 separator 0.97580945 ¶ 1379 1381 W3154071403.pdf 2 28 table 0.984032 "Tnfrsf11a RANK Osteopetrosis Abnormal bone and tooth morphology Abnormal osteoclast differentiation Decreased osteoclast cell number1860238 2183226 3664109" 1381 1547 W3154071403.pdf 2 29 bibliography 0.996593 "Dougall et al., 1999; Li et al., 2000; Kapur et al., 2004" 1547 1606 W3154071403.pdf 2 30 separator 0.962318 ¶ 1606 1608 W3154071403.pdf 2 31 table 0.9892589 "Tnfsf11 RANKL Osteopetrosis Abnormal bone and tooth morphology Abnormal bone mineralisation Decreased bone resorption Abnormal osteoclast physiology Decreased osteoclast cell number Abnormal chondrocyte morphology and differentiation1859962 2386263 5297062 5307891 5614816" 1608 1901 W3154071403.pdf 2 32 bibliography 0.99695766 "Kong et al., 1999; Kim et al., 2000; Nakashima et al., 2011; Douni et al., 2012; Palmer et al., 2016" 1901 2005 W3154071403.pdf 2 33 separator 0.975898 ¶ 2005 2007 W3154071403.pdf 2 34 table 0.98777485 "Traf6 TRAF6 Osteopetrosis Abnormal bone and tooth morphology Decreased bone resorption Abnormal osteoclast morphology and physiology1859953 ¶" 2007 2155 W3154071403.pdf 2 35 bibliography 0.9580833 2675469Lomaga et al., 1999; Naito et al., 1999 2155 2202 W3154071403.pdf 2 36 separator 0.8652376 ¶ 2202 2204 W3154071403.pdf 2 37 table 0.98828375 "Nfkb1 Nfkb2NF-κB Osteopetrosis Abnormal bone structure and morphology Abnormal osteoclast differentiation Decreased osteoclast cell number3852643" 2204 2358 W3154071403.pdf 2 38 bibliography 0.9963149 "Franzoso et al., 1997; Iotsova et al., 1997; Yamashita et al., 2007" 2358 2428 W3154071403.pdf 2 39 separator 0.9130347 ¶ 2428 2430 W3154071403.pdf 2 40 table 0.9616243 "Fos c-Fos Osteopetrosis Abnormal bone and tooth morphology Decreased osteoclast cell number2181817" 2430 2533 W3154071403.pdf 2 41 bibliography 0.9818971 Wang et al., 1992 2533 2551 W3154071403.pdf 2 42 separator 0.5451412 ¶ 2551 2553 W3154071403.pdf 2 43 table 0.9808374 "Nfatc1 NFATc1 Osteopetrosis Abnormal bone and tooth morphology Abnormal osteoclast differentiation Decreased osteoclast cell number3831720" 2553 2698 W3154071403.pdf 2 44 bibliography 0.9953119 Asagiri et al., 2005; Aliprantis et al., 2008 2698 2744 W3154071403.pdf 2 45 separator 0.9296994 ¶ 2744 2746 W3154071403.pdf 2 46 table 0.9871364 "Fcer1g FcR γ No skeletal effects Normal bone volume and osteoclast function, size or number1857165" 2746 2849 W3154071403.pdf 2 47 bibliography 0.90637064 Mócsai et al., 2004 2849 2869 W3154071403.pdf 2 48 table 0.97892773 "¶ Fcer1g TyrobpFcRγ DAP12Osteopetrosis Abnormal bone morphology Increased bone mass Decreased bone resorption Abnormal osteoclast differentiation3818498" 2869 3034 W3154071403.pdf 2 49 bibliography 0.8178482 Mócsai et al., 3034 3049 W3154071403.pdf 2 50 table 0.9774659 "2004 Tyrobp DAP12 Osteopetrosis Nasu-Hakola disease Abnormal bone morphology, remodeling and mineralisation Decreased bone resorption Abnormal osteoclast physiology and differentiation2386271 ¶" 3049 3255 W3154071403.pdf 2 51 bibliography 0.9936697 "2386277Tomasello et al., 2000; Mócsai et al., 2004; Nataf et al., 2005" 3255 3328 W3154071403.pdf 2 52 separator 0.9076316 ¶ 3328 3330 W3154071403.pdf 2 53 paratext 0.7235818 (Continued) 3330 3342 W3154071403.pdf 2 54 separator 0.9439123 ¶ 3342 3344 W3154071403.pdf 2 55 paratext 0.9722171 Frontiers in Cell and Developmental Biology | www.frontier sin.org 3 April 2021 | Volume 9 | Article 641162 3344 3452 W3154071403.pdf 2 0 paratext 0.8145436 6 0 1 W4362735498.pdf 5 1 separator 0.99333286 ¶ 2 4 W4362735498.pdf 5 2 table 0.8567437 "Yield: 6.3 g (65 %). 1H-NMR, (500 MHz, D 2O)  (ppm): 1.9 (m, 4 H, CH 2alkyl), 3.2 (t, 12 H, J = 7,5 Hz, CH 2DABCO), 3.3 (m, 4 H, CH 2alkyl), 3.4 (t, 12 H, J = 7.5 Hz, CH 2DABCO)." 5 188 W4362735498.pdf 5 3 separator 0.9420088 ¶ 190 192 W4362735498.pdf 5 4 table 0.9719636 "MS (L -SIMS: pos. / Matrix: Glycerine) m/z: 279 (M – 2 I)2+, 407 (M – I)+. EA: C 16H32N4I2: Cal. C, 35.97; H, 6.04; N, 10.49. Exp. C, 34.68; H, 5.54; N, 9.80." 192 355 W4362735498.pdf 5 5 separator 0.8344463 ¶ ¶ 357 363 W4362735498.pdf 5 6 table 0.84559053 1,1 ́-(1,5-Pentandiyl)bis[4 -aza-1-azoniabicyclo[2.2.2]octan]dibromide (DABCO -5) 363 444 W4362735498.pdf 5 7 separator 0.9541616 ¶ 445 447 W4362735498.pdf 5 8 table 0.7548185 "Yield: 3.4 g (42 %). 1H-NMR, (500 MHz, D 2O)  (ppm): 1.5 (m, 2 H, CH 2alkyl), 1.9 (m, 4 H, CH 2alkyl), 3.2 (t, 12 H, J = 7.3 Hz, CH 2DABCO), 3.3 (t, 4 H, J = 7.6 Hz, CH 2alkyl), 3.4 (t, 12 H, J = 7.3 Hz, CH 2DABCO)." 447 670 W4362735498.pdf 5 9 separator 0.9226979 ¶ 672 674 W4362735498.pdf 5 10 table 0.96335995 "MS (L -SIMS: pos. / Matrix: Glycerine) m/z: 293 (M – 2 Br)2+, 373/375 (M – Br)+. EA: C 17H34N4Br2: Cal. C, 44.95; H, 7.54; N, 12.33. Exp. C, 42.66; H, 7.38; N, 10.85." 674 844 W4362735498.pdf 5 11 separator 0.8525753 ¶ ¶ 846 852 W4362735498.pdf 5 12 table 0.863278 1,1 ́-(1,6-Hexandiyl)bis[4 -aza-1-azoniabicyclo[2.2.2]octan]dibromide (DABCO -6) 852 932 W4362735498.pdf 5 13 separator 0.9582297 ¶ 933 935 W4362735498.pdf 5 14 table 0.7403603 "Yield: 6.1 g (72 %). 1H-NMR, (500 MHz, D 2O)  (ppm): 1.4 (m, 4 H, CH 2alkyl), 1.8 (m, 4 H, CH 2alkyl), 3.2 (t, 12 H, J = 7.2 Hz, CH 2DABCO), 3.3 (t, 4 H, J = 8.5 Hz, CH 2alkyl), 3.4 (t, 12 H, J = 7.2 Hz, CH 2DABCO)." 935 1158 W4362735498.pdf 5 15 separator 0.90290904 ¶ 1160 1162 W4362735498.pdf 5 16 table 0.9613053 "MS (L -SIMS: pos. / Matrix: Glycerine) m/z: 307 (M – 2 Br)2+, 387/389 (M – Br)+. EA: C 18H36N4Br2: Cal. C, 46.16; H, 7.75; N, 11.96. Exp.: C, 42.51; H, 7.69; N, 10.53." 1162 1334 W4362735498.pdf 5 17 separator 0.89298093 ¶ ¶ 1336 1342 W4362735498.pdf 5 18 table 0.8310437 1,1 ́-(1,7-Heptandiyl)bis[4 -aza-1-azoniabicyclo[2.2.2]octan]dibro mide (DABCO -7) 1342 1424 W4362735498.pdf 5 19 separator 0.9626471 ¶ 1425 1427 W4362735498.pdf 5 20 table 0.7889774 "Yield: 5.0 g (58 %). 1H-NMR, (500 MHz, D 2O)  (ppm): 1.4 (m, 6 H, CH 2alkyl), 1.8 (m, 4 H, CH 2alkyl), 3.2 (t, 12 H, J = 8.0 Hz, CH 2DABCO), 3.3 (m, 4 H, CH 2alkyl), 3.4 (t, 12 H, J = 8.0 Hz, CH 2DABCO)." 1427 1638 W4362735498.pdf 5 21 separator 0.8457844 ¶ 1640 1642 W4362735498.pdf 5 22 table 0.94953346 "MS (L -SIMS: pos. / Matrix: Glycerine) m/z: 321 (M – 2 Br)2+, 401/403 (M – Br)+. EA: C 19H38N4Br2: Cal. C, 47.31; H, 7.94; N, 11.62. Exp.: C, 46.16; H, 7.56; N, 10.72." 1642 1815 W4362735498.pdf 5 23 separator 0.95848966 ¶ ¶ 1817 1823 W4362735498.pdf 5 24 text 0.9555801 "The calculated values of the elemental analysis and the experimental results differ for some of the synthesized compounds. The bromide and iodide derivatives of DABCO are strong hydroscopic and this may lead to the observed differences. However, even the r esults from elemental analysis of DABCO itself show differences between calculated and experimental values: C 6H12N2: Calc.: ¶" 1823 2217 W4362735498.pdf 5 25 table 0.4432169 C, 6 2217 2222 W4362735498.pdf 5 26 text 0.48074692 4.24 2222 2226 W4362735498.pdf 5 27 table 0.4822607 ; H, 10 2226 2233 W4362735498.pdf 5 28 text 0.4766685 .78 2233 2236 W4362735498.pdf 5 29 table 0.4655283 ; N, 24. 2236 2244 W4362735498.pdf 5 30 text 0.46252272 97. Exp.: 2244 2253 W4362735498.pdf 5 31 table 0.43202245 C, 58 2253 2259 W4362735498.pdf 5 32 text 0.47377282 .55; 2259 2263 W4362735498.pdf 5 33 table 0.4680375 H 2263 2265 W4362735498.pdf 5 34 text 0.45416453 , 10.58; 2265 2273 W4362735498.pdf 5 35 table 0.4208498 N 2273 2275 W4362735498.pdf 5 36 text 0.9543227 ", 22.21. However, a definitive characterisation of the synthesized compound s is possible from 1H-NMR and mass spectrometry." 2275 2403 W4362735498.pdf 5 37 separator 0.99559677 ¶ 2405 2407 W4362735498.pdf 5 0 paratext 0.98315203 J Clin Exp Dent. 2020;12(5):e488-93. 0 36 W3021744122.pdf 3 1 title 0.7503371 e491Mandibular task 200 220 W3021744122.pdf 3 2 table 0.9924402 "s Muscles ARG CG p value Rest RM .04 ± .001 .05 ± .01 .37 LM .05 ± .008 .05 ± .01 .24 RT .12 ± .02 .13 ± .02 .85 LT .12 ± .02 .11 ± .01 .60 Right laterality RM .05 ± .007 .09 ± .03 .16 LM .07 ± .02 .07 ± .02 .90 RT .18 ± .03 .27 ± .07 .29 LT .14 ± .03 .10 ± .01 .26 Left laterality RM .07 ± .01 .11 ± .03 .33 LM .06 ± .007 .06 ± .009 .66 RT .10 ± .02 .14 ± .03 .37 LT .13 ± .03 .17 ± .01 .28 Protrusion RM .11 ± .03 .17 ± .05 .32 LM .18 ± .05 .12 ± .02 .34 RT .11 ± .02 .14 ± .03 .56 LT .12 ± .02 .12 ± .03 .96 Maximal voluntary contractionRM .83 ± .07 .71 ± .09 .34 LM .80 ± .10 .57 ± .08 .10 RT .98 ± .05 .77 ± .05 .01* LT .95 ± .06 .72 ± .05 .01*" 220 916 W3021744122.pdf 3 3 caption 0.9791194 "Table 3 : Means, standard errors (±) and statistical significance ( p < .05*) of the normalized electromyo - graphic data averages of the right masseter (RM), left masseter (LM), right temporal (RT) and left temporal (LT) for chronic allergic rhinitis group (ARG) and control group (CG) in the mandibular tasks." 916 1232 W3021744122.pdf 3 4 separator 0.995582 ¶ 1232 1234 W3021744122.pdf 3 5 text 0.99940836 "In this study, it was observed that the electromyographic activities of the masseter and temporalis muscles were similar between groups during mandibular rest. This fact reveals the existence of postural maintenance with acti - vation of muscle fibers in the healthy organism (21,22) and functional alteration (23)." 1234 1564 W3021744122.pdf 3 6 separator 0.8025569 ¶ 1564 1566 W3021744122.pdf 3 7 text 0.99938375 "During the protrusion, the chronic allergic rhinitis group demonstrated an adequate neuroanatomic pattern of muscle activation to maintain the postural position (21)." 1566 1739 W3021744122.pdf 3 8 separator 0.84815633 ¶ 1740 1742 W3021744122.pdf 3 9 text 0.9995866 "In this condition, changes in normalized electromyo - graphic means of the masseter muscles were observed between the groups. This situation may be related to the functional imbalance of the stomatognathic system due to the oral breathing pattern (24). The buccal brea - thing pattern in subjects affected by upper airway in - flammation promotes muscle compensations that trigger functional imbalance (25)." 1742 2168 W3021744122.pdf 3 10 separator 0.9749468 ¶ 2168 2170 W3021744122.pdf 3 11 text 0.9996723 "During right and left laterality, the chronic allergic rhi - nitis group had lower normalized electromyographic means than the control group, without significant diffe - rence. The results presented are directed at the muscles that effectively participated in the neuroanatomic mus - cle activation pattern. In this pattern there was greater electromyographic ac - tivation of the temporal muscle on the same side of the mandible that extends to the functional side, while in the masseter muscle the highest activation was contralateral to movement (23). The hypothesis for the lowest norma - lized electromyographic means of the masticatory mus - cles may be related to the buccal breathing pattern (26)." 2170 2903 W3021744122.pdf 3 12 separator 0.9867155 ¶ 2903 2905 W3021744122.pdf 3 13 text 0.99947286 "Normalized electromyographic activity in the present investigation was measured in the maximal isometric contraction of the masseter and temporalis muscles in both groups. Higher electromyographic means were demonstrated in the group with chronic allergic rhinitis when compared to the control group, with significant di - fference for the temporalis muscles." 2905 3282 W3021744122.pdf 3 14 separator 0.9806961 ¶ 3282 3284 W3021744122.pdf 3 15 text 0.9994727 "Muscle performance may be influenced by topical na - sal decongestants containing vasoconstrictors used to treat allergic rhinitis. Studies indicate that small doses of vasoconstrictors, for example adrenaline, constantly re - leased into the bloodstream, promote acute vasodilation, increasing the caliber of vessels and arteries present in skeletal striated muscle through beta-adrenergic mecha - nism (27)." 3284 3712 W3021744122.pdf 3 16 separator 0.9913819 ¶ 3712 3714 W3021744122.pdf 3 17 text 0.9912569 Chronic administration of substances that help treat res - 3714 3773 W3021744122.pdf 3 0 paratext 0.98421437 S. Narison / Physics Letters B 784 (2018) 261–265 265 0 53 W2885497018.pdf 5 1 separator 0.9899971 ¶ 53 55 W2885497018.pdf 5 2 title 0.98222905 Table 4 55 63 W2885497018.pdf 5 3 separator 0.98381364 ¶ 63 65 W2885497018.pdf 5 4 title 0.5140391 Charm and 65 76 W2885497018.pdf 5 5 table 0.46021852 bottom 76 82 W2885497018.pdf 5 6 title 0.47691116 running masses 83 99 W2885497018.pdf 5 7 table 0.54193187 mc,b(mc,b)from 100 115 W2885497018.pdf 5 8 title 0.4670793 ( 115 117 W2885497018.pdf 5 9 table 0.44594643 ra 117 119 W2885497018.pdf 5 10 title 0.4515184 - 119 121 W2885497018.pdf 5 11 table 0.49946967 ¶ 121 122 W2885497018.pdf 5 12 title 0.53287077 tios 122 127 W2885497018.pdf 5 13 table 0.47829247 of 127 130 W2885497018.pdf 5 14 title 0.46732724 ) 130 131 W2885497018.pdf 5 15 table 0.59342855 moments. 131 140 W2885497018.pdf 5 16 separator 0.85256493 ¶ 140 142 W2885497018.pdf 5 17 table 0.99284077 "Observables Mass [MeV] Charm M4(0) 1266(9.0) r3/4(0) 1264(11.1) M10(4m2 c) 1263(2.3) M16(8m2 c) 1261(1.3) Mean 1264(6) Bottom M6(0)⊕r4/5(0) 4186(9.3) M10(4m2 b)⊕r9/10(4m2 b) 4189(7.5) M13(8m2 b)⊕r10/11(8m2 b) 4188(6.7) Mean 4188(8)" 142 408 W2885497018.pdf 5 18 separator 0.99123234 ¶ 408 410 W2885497018.pdf 5 19 text 0.9947492 "use of the higher moments and their ratios reduce notably the er- rors in the mass determinations. Though it is difficult to estimate the systematic errors of the approach, we can expect that they are at most equal to the ones quoted in this paper. These new re- sults are also in perfect agreement with the ones quoted in Eq. (5) from a recent global fit of the (axial-)vector and (pseudo)scalar charmonium and bottomium systems using Laplace sum rules [3]." 410 907 W2885497018.pdf 5 20 separator 0.8117361 ¶ 908 910 W2885497018.pdf 5 21 text 0.994503 "Some comments on the existing estimates of the quark masses and gluon condensates from SVZ-(ratios of) moments are given in Section 5. Our results are comparable with recent results from non-relativistic approaches [33]b u t more accurate." 910 1174 W2885497018.pdf 5 22 separator 0.9958806 ¶ 1174 1176 W2885497018.pdf 5 23 title 0.7740195 References 1176 1187 W2885497018.pdf 5 24 separator 0.986889 ¶ 1187 1189 W2885497018.pdf 5 25 bibliography 0.9933707 "[1]S. Narison, Phys. Lett. B 706 (2012) 412. [2]S. Narison, Phys. Lett. B 693 (2010) 559, Erratum: Phys. Lett. 705 (2011) 544.[3]S. Narison, Int. J. Mod. Phys. A 33 (10) (2018) 1850045." 1189 1382 W2885497018.pdf 5 26 separator 0.92806375 ¶ 1382 1384 W2885497018.pdf 5 27 bibliography 0.98802847 "[4]M.A . Shifman, A.I. Vainshtein, V.I. Zakharov, Nucl. Phys. B 147 (1979) 385. [5]M.A . Shifman, A.I. Vainshtein, V.I. Zakharov, Nucl. Phys. B 147 (1979) 448. [6]V.I. Zakharov, Talk given at the Sakurai’s price, Int. J. Mod. Phys. A 14 (1999) 4865." 1384 1651 W2885497018.pdf 5 28 separator 0.88830453 ¶ 1651 1653 W2885497018.pdf 5 29 bibliography 0.9975222 "[7]S. Narison, Camb. Monogr. Part. Phys. Nucl. Phys. Cosmol. 17 (2004) 1–778, arXiv:hep -ph /0205006." 1653 1762 W2885497018.pdf 5 30 separator 0.73861754 ¶ 1762 1764 W2885497018.pdf 5 31 bibliography 0.98672944 "[8]S. Narison, World Sci. Lect. Notes Phys. 26 (1989) 1. [9]S. Narison, Phys. Rep. 84 (1982) 263. [10]S. Narison, Acta Phys. Pol. B 26 (1995) 687. [11]L.J. Reinders, H. Rubinstein, S. Yazaki, Phys. 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Phys. B 254 (1985) 55. [24]K. Chetyrkin, R. Harlander, J.H. Kuhn, M. Steinhauser, Nucl. Phys. B 503 (1997) 339." 2737 2918 W2885497018.pdf 5 36 separator 0.6451216 ¶ 2918 2920 W2885497018.pdf 5 37 bibliography 0.9977991 "[25]B. Dehnadi, A.H. Hoang, V. Mateu, S.M. Zebarjad, J. High Energy Phys. 1309 (2013) 103." 2920 3016 W2885497018.pdf 5 38 separator 0.5638454 ¶ 3016 3018 W2885497018.pdf 5 39 bibliography 0.9964989 "[26]K.G. Chetyrkin, et al., Phys. Rev. D 80 (2009) 074010; K.G. Chetyrkin, et al., Phys. Rev. D 96 (2017) 116007." 3018 3136 W2885497018.pdf 5 40 separator 0.60573447 ¶ 3136 3138 W2885497018.pdf 5 41 bibliography 0.98049104 "[27]A. Maier, et al., Nucl. Phys. B 824 (2010) 1. [28]R. Boughezal, M. Czakon, T. Schutzmeier, Phys. Rev. D 74 (2006) 074006. [29]S. Narison, V.I. Zakharov, Phys. Lett. B 522 (2001) 266." 3138 3334 W2885497018.pdf 5 42 separator 0.5956775 ¶ 3334 3336 W2885497018.pdf 5 43 bibliography 0.98634833 "[30]D.J. Broadhurst, P.A. Baikov, V.A. Ilyin, J. Fleischer, O.V. Tarasov, V.A. Smirnov, Phys. Lett. B 329 (1994) 103. [31]D. Boito, et al., Phys. Rev. D 91 (3) (2015) 034003. [32]A. Pich, A. Rodriguez-Sanchez, Phys. Rev. D 94 (3) (2016) 034027." 3336 3593 W2885497018.pdf 5 44 separator 0.75703025 ¶ 3593 3595 W2885497018.pdf 5 45 bibliography 0.9978452 [33]C. Peset, A. Pineda, J. Segovia, arXiv:1806 .05197, 2018. 3595 3661 W2885497018.pdf 5 0 paratext 0.9842344 "Prosiding Seminar Nas ional Fisika (E -Journal) VOLUME XI, JANUARI 2023 p-ISSN: 2339 -0654 e-ISSN: 2476 -9398" 0 115 W4323899612.pdf 3 1 separator 0.5094143 116 117 W4323899612.pdf 3 2 paratext 0.4925095 ¶ 117 118 W4323899612.pdf 3 3 separator 0.5575502 ¶ 120 122 W4323899612.pdf 3 4 paratext 0.8745238 "Seminar Nasional Fisika 202 2 Program Studi Fisika dan Pendidikan Fisika , Fakultas MIPA, Universitas Negeri J akarta" 122 244 W4323899612.pdf 3 5 separator 0.96602863 ¶ 246 248 W4323899612.pdf 3 6 title 0.9913172 PF-4 Development (Pengembangan) 248 280 W4323899612.pdf 3 7 separator 0.9946343 ¶ 282 284 W4323899612.pdf 3 8 text 0.99865633 "Setelah membuat rancangan, seluruh rancangan dan desain direalisasikan menjadi modul digital fisika. Bedasarkan diagram alir pada rancangan model, setelah proses tahap pembuatan modul digit al akan diuji kelayak an dari produk , maka dalam tahap ini akan dilakukan beberapa kegiatan, yaitu:" 284 583 W4323899612.pdf 3 9 separator 0.9864501 ¶ 585 587 W4323899612.pdf 3 10 text 0.6080531 587 588 W4323899612.pdf 3 11 title 0.84180284 a. Realisasi desain media pembelajaran 588 626 W4323899612.pdf 3 12 text 0.5688112 . 626 627 W4323899612.pdf 3 13 separator 0.95743465 ¶ 629 631 W4323899612.pdf 3 14 text 0.9990741 "Pada tahapan ini skema dan desain produk yang telah dibuat akan direalisasikan menggunakan sigil s oftware , sehingga meng hasilkan sebu ah produk berupa modul digital EMO -GE (Elektronik Modul Geothermal) sebagai media/bahan belajar bagi si swa." 631 884 W4323899612.pdf 3 15 separator 0.99631965 ¶ 885 887 W4323899612.pdf 3 16 title 0.98153496 b. Uji validasi kelayakan ahli materi dan ahli media. 887 941 W4323899612.pdf 3 17 separator 0.9824916 ¶ 943 945 W4323899612.pdf 3 18 text 0.9958761 "Pada tahap ini dibutuhkan instrumen berupa angket penilaian da ri ahli materi dan ahl i media. Hasil dari uji validasi kelayakan dari ahli media dan ahli materi akan digunakan untuk meperbaiki /merevisi produk, sehingga produk layak digunakan sebagai media belajar bagi siswa." 945 1232 W4323899612.pdf 3 19 separator 0.9955148 ¶ 1234 1236 W4323899612.pdf 3 20 title 0.98557323 c. Revisi 1236 1246 W4323899612.pdf 3 21 separator 0.99443877 ¶ 1248 1250 W4323899612.pdf 3 22 text 0.99953884 "Revisi merupakan suatu tahapan di mana menjadikan suatu pr oduk layak d igunakan oleh siswa sebagai media belajar yang akan membatu siswa dalam memahami materi." 1250 1415 W4323899612.pdf 3 23 separator 0.99705565 ¶ 1417 1419 W4323899612.pdf 3 24 title 0.99257 Implementation (Implementasi) 1419 1449 W4323899612.pdf 3 25 separator 0.9942394 ¶ 1451 1453 W4323899612.pdf 3 26 text 0.99719167 "Pada tahap implementasi , hal yang dilakukan yaitu uji coba dalam pembelajaran fisika. Hasil dari pengem bangan media belajar a kan diuji cob a kepada guru dan peserta didik SMAN 21 Jakarta. Kemudian guru dan peserta didik diberi angket sebagai hasil kelayakan dan sebagai tempat saran dan kritik modul digital." 1453 1775 W4323899612.pdf 3 27 separator 0.9969231 ¶ 1777 1779 W4323899612.pdf 3 28 title 0.99237967 Evaluation (Evaluasi) 1779 1801 W4323899612.pdf 3 29 separator 0.9948839 ¶ 1803 1805 W4323899612.pdf 3 30 text 0.9995979 "Evaluasi dilakukan pada setia p tahapan proses, sete lah menganali sis data, merancang produk, membuat produk, serta setelah melakukan implementasi. Tahap evaluasi dilaku kan perbaikan dari pengembangan produk." 1805 2022 W4323899612.pdf 3 31 separator 0.9952025 ¶ 2024 2026 W4323899612.pdf 3 32 title 0.9909716 HASIL DAN PEMBAHASAN 2026 2047 W4323899612.pdf 3 33 separator 0.9962724 ¶ 2049 2051 W4323899612.pdf 3 34 text 0.99397105 "Aplikasi Canva sebagai salah satu aplikasi online yang g ratis dan berbayar berb asis online dapat digunakan untuk mendesah media pembelajaran dengan beberapa template yang tersedia [9]. Aplikasi Canva merupakan aplikasi desain grafis yang menyediakan tools berupa input foto, video, dan font. Materi yang digunak an dalam penelitian ini adalah sumb er energi Panas Bumi. Secara geologis Indonesia terletak di pertemuan tiga lempeng tektonik utama, lemp eng Eurasia, Indo - Australia, dan Pasifik. Kondisi geologis in i berdampak pada jumlah energi panas bumi di Indonesia." 2051 2647 W4323899612.pdf 3 35 separator 0.97952616 ¶ 2648 2650 W4323899612.pdf 3 36 text 0.9993111 "Modul digital berfungsi sebagai baha n ajar yang dicetak dan dikembangkan dalam bentuk digital sehingga pembelajaran siswa tidak lagi bergan tung pada guru sebagai satu -satunya sumber informasi [10]. Med ia pembelajaran elektronik saat ini dibuat menarik dan m enyenangkan sehingga pr oses pembela jaran tercapai dengan baik, salah satu media pembelajaran elektronik adalah bahan ajar berupa modul digi tal [1 1]. Modul digital adalah versi elektron ik dari modul cetak yang dapat dibaca di komputer atau android, di mana pembuatan modul digital memerlukan perangkat lunak . Modul digital adalah modul cetak versi elektronik, perangkat yang digunakan seperti komputer, laptop, handphone atau perangkat e lektronik lainnya [1 2]. Modul digital merupakan bentuk penyajian materi pemb elajaran mandiri yang d isusun secar a sistematis menjadi satuan pembelajaran terkecil untuk mencapai tujuan pembelajaran tertentu, yang disajikan ke dalam format elektronik di mana terdapat animasi, audio, navigasi yang membuat pengguna lebih interaktif dan sifat penggunaannya. Modul digital berfungsi sebagai bahan ajar yang dicetak dan dikembangkan dalam bentuk digital sehingga pembelajar an siswa tidak lagi bergantung pada guru se bagai satu -satunya sumber informasi [9]." 2650 3955 W4323899612.pdf 3 37 separator 0.93392015 ¶ 3957 3959 W4323899612.pdf 3 38 text 0.9982079 "Modul pembelajaran digital yang baik memiliki beberapa kara kteristik, y aitu self-instruction, self - contained, stand alone, adaptive and user friendly." 3959 4117 W4323899612.pdf 3 0 paratext 0.67955774 RESEARCH ARTICLE 0 16 W3014614299.pdf 0 1 separator 0.9375944 ¶ 16 18 W3014614299.pdf 0 2 title 0.9888333 "Cerebellar –cortical dysconnectivity in resting-state associated with sensorimotor tasks in schizophrenia" 18 126 W3014614299.pdf 0 3 separator 0.9940229 ¶ 126 128 W3014614299.pdf 0 4 contact 0.71047527 Dae-Jin Kim1| Alexandra B. Moussa-Tooks1,2| Amanda R. Bolbecker 128 192 W3014614299.pdf 0 5 table 0.5257554 1,3| 192 197 W3014614299.pdf 0 6 contact 0.6626406 ¶ Deborah Apthorp4,5 197 217 W3014614299.pdf 0 7 table 0.53619534 | 217 218 W3014614299.pdf 0 8 contact 0.67185336 Sharlene D. Newman1,2 218 240 W3014614299.pdf 0 9 table 0.5627907 | 240 241 W3014614299.pdf 0 10 contact 0.66244346 Brian F. O'Donnell 241 260 W3014614299.pdf 0 11 table 0.5909669 1,2,3| 260 266 W3014614299.pdf 0 12 contact 0.76783353 ¶ William P. Hetrick1,2,3 266 292 W3014614299.pdf 0 13 separator 0.9462499 ¶ 292 294 W3014614299.pdf 0 14 contact 0.9842828 "1Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana 2Program in Neuroscience, Indiana University, Bloomington, Indiana 3Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 4School of Psychology, Faculty of Medicine and Health, University of New England, Armidale, New South Wales, Australia 5Research School of Computer Science, College of Engineering and Computer Science, Australian National University, Canberra, Australian Capital Territory, Australia" 294 849 W3014614299.pdf 0 15 separator 0.9618891 ¶ 849 851 W3014614299.pdf 0 16 contact 0.9811341 "Correspondence Dae-Jin Kim, Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405.Email: daejkim@indiana.edu" 851 1002 W3014614299.pdf 0 17 separator 0.98913974 ¶ 1002 1004 W3014614299.pdf 0 18 title 0.66082346 Funding information 1004 1024 W3014614299.pdf 0 19 separator 0.96500397 ¶ 1024 1026 W3014614299.pdf 0 20 contact 0.44679135 Brain and Behavior Research Foundation; 1026 1067 W3014614299.pdf 0 21 text 0.32392517 ¶ 1067 1068 W3014614299.pdf 0 22 contact 0.46249947 Indiana 1068 1076 W3014614299.pdf 0 23 text 0.37581652 Clinical 1076 1085 W3014614299.pdf 0 24 contact 0.41209382 and Translational SciencesInstitute, Grant/Award Numbers: TL1 1085 1147 W3014614299.pdf 0 25 bibliography 0.35115352 1147 1148 W3014614299.pdf 0 26 text 0.35034245 ¶ 1148 1149 W3014614299.pdf 0 27 contact 0.38493356 TR001107, UL1 TR001108; National Institute 1149 1192 W3014614299.pdf 0 28 text 0.3740537 ¶ of Mental Health, Grant 1192 1218 W3014614299.pdf 0 29 contact 0.3392227 / 1218 1219 W3014614299.pdf 0 30 text 0.42389163 "Award Numbers: R01 MH074983, R21 MH091774, T32 MH103213" 1219 1276 W3014614299.pdf 0 31 title 0.8290735 Abstract 1276 1284 W3014614299.pdf 0 32 separator 0.99559546 ¶ 1284 1286 W3014614299.pdf 0 33 text 0.99964654 "Abnormalities of cerebellar function have been implicated in the pathophysiology of schizophrenia. Since the cerebellum has afferent and efferent projections to diverse brain regions, abnormalities in cerebellar lobules could affect functional connectivity with multiple functional systems in the brain. Prior studies, however, have not exam- ined the relationship of individual cerebellar lobules with motor and nonmotor resting-state functional networks. We evaluated these relationships using resting-state fMRI in 30 patients with a schizophrenia-spectrum disorder and 37 healthy comparison participants. For connectivity analyses, the cerebellum was parcellated into 18 lobular and vermal regions, and functional connectivity of each lobule to 10 major functional networks in the cerebrum was evaluated. The relationship between functional connectivity measures and behavioral performance on sensori- motor tasks (i.e., finger-tapping and postural sway) was also examined. We found cerebellar –cortical hyperconnectivity in schizophrenia, which was predominantly associated with Crus I, Crus II, lobule IX, and lobule X. Specifically, abnormal cerebel- lar connectivity was found to the cerebral ventral attention, motor, and auditory net- works. This cerebellar –cortical connectivity in the resting-state was differentially associated with sensorimotor task-based behavioral measures in schizophrenia and healthy comparison participants —that is, dissociation with motor network and associ- ation with nonmotor network in schizophrenia. These findings suggest that functional association between individual cerebellar lobules and the ventral attentional, motor, and auditory networks is particularly affected in schizophrenia. They are also consis- tent with dysconnectivity models of schizophrenia suggesting cerebellar contribu- tions to a broad range of sensorimotor and cognitive operations." 1286 3231 W3014614299.pdf 0 34 separator 0.99665576 ¶ 3231 3233 W3014614299.pdf 0 35 title 0.79543316 KEYWORDS 3233 3242 W3014614299.pdf 0 36 separator 0.9774182 ¶ 3242 3244 W3014614299.pdf 0 37 text 0.37765014 cere 3244 3249 W3014614299.pdf 0 38 paratext 0.2752778 bell 3249 3253 W3014614299.pdf 0 39 text 0.32939053 um, functional 3253 3267 W3014614299.pdf 0 40 paratext 0.31410065 connectivity 3267 3280 W3014614299.pdf 0 41 text 0.31359532 , schizophrenia, finger 3280 3303 W3014614299.pdf 0 42 paratext 0.8521855 "tapping, postural swayReceived: 2 December 2019 Revised: 15 March 2020 Accepted: 25 March 2020 DOI: 10.1002/hbm.25002" 3303 3423 W3014614299.pdf 0 43 separator 0.54277253 3423 3424 W3014614299.pdf 0 44 paratext 0.95017284 "¶ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any me dium, provided the original work is properly cited." 3424 3630 W3014614299.pdf 0 45 separator 0.6026803 ¶ 3630 3632 W3014614299.pdf 0 46 paratext 0.9846571 © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. 3632 3709 W3014614299.pdf 0 47 separator 0.5347208 3709 3710 W3014614299.pdf 0 48 paratext 0.97438437 ¶ Hum Brain Mapp. 2020;41:3119 –3132. wileyonlinelibrary.com/journal/hbm 3119 3710 3787 W3014614299.pdf 0 0 bibliography 0.9661533 "Sakran, Sergio Susmallian, Levent Karagöz, Murat Akbaba, Salih Zeki Pişkin, Ahmet Ziya Balta, Zafer Senol, Emilio Manno, Michele Giuseppe Iovino, Ahmed Osman, Mohamed Qassem, Sebastián Arana-Garza, Heitor P. Povoas, Marcos Leão Vilas-Boas, David Naumann, Jonathan Super, Alan Li, Basil J Ammori, Hany Balamoun, Mohammed Salman, Amrit Manik Nasta, Ramen Goel, Hugo Sánchez-Aguilar, Miguel F Herrera, Adel Abou-Mrad, Lucie Cloix, Guilherme Silva Mazzini, Leonardo Kristem, Andre Lazaro, Jose Campos, Joaquín Bernardo, Jesús González, Carlos Trindade, Octávio Viveiros, Rui Ribeiro, David Goitein, David Hazzan, Lior Segev, Tamar Beck, Hernán Reyes, Jerónimo Monterrubio, Paulina García, Marine Benois, Radwan Kassir, Alessandro Contine, Moustafa Elsh afei, Sueleyman Aktas, Sylvia Weiner, Till Heidsieck, Luis Level, Silvia Pinango, Patricia Martinez Ortega, Rafael Moncada, Victor Valenti, Ivan Vlahovi ć. Zdenko Boras, Arnaud Liagre, Francesco Martini, Gildas Juglard, Manish Motwani, Sukhvinder Singh Saggu, Hazem Al Momani, Luis Adolfo Aceves López, María Angelina Contreras C ortez, Rodrigo Aceves Zavala, Christine D ’Haese RN, Ivo Kempeneers, Jacques Himpens, Andrea Lazzati, Luca Paolino, Sarah Bathaei, Abdulkadir Bedirli, Ayd ın Yavuz, Ça ğrıBüyükkasap, Safa Özayd ın, Andrzej Kwiatkowski, Katarzyna Bartosiak, Maciej Wal ędziak, Antonella Santonicola, Luigi Angrisani, Paola Iovino, Rossella Palma, Angelo Iossa, Cristian Eugeniu Boru, Francesco De Angelis, Gianfranco Silecchia, Abdulzahra Hussain, Srivinasan B alchandra, Izaskun Balciscueta Coltell, Javier Lorenzo Pérez, Ashok Bohra, Altaf K Awan, Brijesh Madhok, Paul C Leeder, Sherif Awad, Waleed Al-Khyatt, Ashraf Shoma, Hosam Elghadban, Sameh Ghareeb, Bryan Mathews, Marina Kurian, Andreas Larentzakis, Gavriella Zoi Vrakopoulou, Konstantinos Albanopoulos, Ahemt Bozdag, Azmi Lale, Cuneyt Kirkil, Mursid Dincer, Ahmad Bashir, Ashraf Haddad, Leen Abu Hijleh, Bruno Zilberstein, Danilo Dallago de Marchi, Willy Petrini Souza, Carl Magnus Brodén, Hjörtur Gislason, Kamran Shah, Antonio Ambrosi, Giovanna Pavone, Nicola Tartaglia, S Lakshmi Kumari Kona, Kalyan K, Cesar Ernesto Guevara Perez, Miguel Alberto Forero Botero, Adrian Covic, Daniel Timofte, Madalina Maxim, Dashti Faraj, Larissa Tseng, Ronald Liem, Gürdal Ören, Evren Dilektasli, Ilker Yalcin, Hudhaifa AlMukhtar, Mohammed Al Hadad, Rasmi Mohan, Naresh Arora, Digvijaysingh Bedi, Claire Rives-Lange, Jean-Marc Chevallier, Tigran Poghosyan, Hugues Sebbag, Lamia Zinaï, Saadi Khaldi, Charles Mauchien, Davide Mazza, Georgiana Dinescu, Bernardo Rea, Fernando Pérez-Galaz, Luis Zavala, Anais Besa, Anna Curell, Jose M Balibrea, Carlos Vaz, Luis Galindo, Nelson Silva, José Luis Estrada Caballero, Sergio Ortiz Sebastian, João Caetano Dallegrave Marchesini, Ricardo Arcanjo da Fonseca Pereira, Wagner Herbert Sobottka, Felipe Eduardo Fiolo, Matias Turchi, Antonio Claudio Jamel Coelho, Andre Luis Zacaron, André Barbosa, Reynaldo Quinino, Gabriel Menaldi, Nicolás Paleari, Pedro Martinez-Duartez, Gabriel Martínez de Aragon Ramírez de Esparza, Valentin Sierra Esteban, Antonio Torres, Jose Luis Garcia- Galocha, Miguel Josa, Jose Manuel Pacheco-Garcia, Maria Angeles Mayo-Ossorio, Pradeep Chowbey, Vandana Soni, Hercio Azevedo de Vasconcelos Cunha, Michel Victor Castilho, Rafael Meneguzzi Alves Ferreira, Thiago Alvim Barreiro, Alexandros Charalabopoulos, Elias Sdralis, Spyridon Davakis, Benoit Bomans, Giovanni Dapri, Koenraad Van Belle, MazenTakieddine, Pol Vaneukem, Esma Seda Akal ınK a r a c a , Fatih Can Karaca, Aziz Sumer, Caghan Peksen, Osman Anil Savas, Elias Chousleb, Fahad Elmokayed, Is lam fakhereldin, Hany Mohamed Aboshanab, Talal Swelium, Ahmad Gudal, Lamees Gamloo, Ayushka Ugale, Surendra Ugale, Clara Boeker, Christian Reetz, Ibrahim Ali Hakami, Julian Mall, Andreas Alexandrou, Efstratia Baili, Zsolt Bodnar, Almantas Maleckas, Rita Gudaityte, Cem Emir Guldogan, Emre Gundogdu, Mehmet Mahir Ozmen, Deepti Thakkar, Nandakishore Dukkipati, Poonam Shashank Shah, Shashank Subhashchandra Shah, Simran Shashank Shah, Md Tanveer Adil, Periyathambi Jambulingam, Ra vikrishna Mamidanna, Douglas Whitelaw, Md Tanveer Adil, Vigyan Jain, Deepa Kizhakke Veetil, Randeep Wadhawan, Antonio To rres, Max Torres, Tabata Tinoco,Wouter Leclercq, Marleen Romeijn, Kelly van de Pas, Ali K. Alkhazraji, Safwan A. Taha, Murat Ustun, Taner Yigit, Aatif Inam, Muhammad Burhanulhaq, Abdo lreza Pazouki, Foolad Eghbali, Mohammad Kermansaravi, Amir Hosein Davarpanah Jazi, Mohsen Mahmoudieh, Neda Mogharehabed, Gregory Tsiotos, Konstantinos Stamou, Francisco J. Barrera Rodriguez, Marco A. Rojas Navarro, Omar Mohamed Torres, Sergio Lopez Martinez, Elda Rocio Maltos Tamez, Gustavo A. Millan Cornejo, Jose Eduardo Garcia Flores, Diya Aldeen Mohammed, Mohamad Hayssam Elfawal, Asim Shabbir, Kim Guowei, Jimmy By So, Elif Tu ğçe Kaplan, Mehmet Kaplan, Tu ğba Kaplan, DangTuan Pham, Gurteshwar Rana, Mojdeh Kappus, Riddish Gadani, Manish Kahitan, Koshish Pokharel, Alan Osborne, Dimitri Pournaras, James Hewes, Errichett a Napolitano, Sonja Chiappetta, Vincenzo Bottino, Evelyn dorado, Axel Schoettler, Daniel Gaertner, Katharina Fedtke, Francisco Aguilar-Espinosa, Saul Aceves-Lozano, Alessandro Balani, Carlo Nagliati, Damiano Pennisi, Andrea Rizzi, Francesco Frattini, Diego Fosch i, Laura Benuzzi, Chirag Parikh, Harshil Shah, Enrico Pinotti, Mauro Montuori, Vincenzo Borrelli, Jerome Dargent, Catalin A Copaescu, Ionut Hutopila, Bogdan Smeu, Bart Witteman, Eric Hazebroek, Laura Deden, Laura Heusschen, Sietske Okkema, Theo Aufenacker, Willem den Hengst, Wouter Vening, Yonta van der Burgh, Ahmad Ghazal, Hamza Ibrahim, Mourad Niazi, Bilal Alkhaffaf, Mohammad Altarawni, Giovanni Carlo Cesana, Marco Anselmino, Matteo Uccelli, Stefano Olmi, Christine Stier, Tahsin Akmanlar, Thomas Sonnenberg, Uwe Schieferbein, Alejandro Marcolini, Diego Awruch, Marco Vicentin, Eduardo Lemos de Souza Bastos, Samuel Azenha Gregorio, Anmol Ahuja, Tarun mittal, Roel Bolckmans, Tom Wiggins, Clément Baratte, Judith Aron Wisnewsky, Laurent Genser, Lynn Chong, Lillian Taylor, Salena Ward, Lynn Chong, Lillian Taylor, Michael W Hi, Helen Heneghan, Naomi Fearon, Andreas Plamper, Karl Rheinwalt, Helen Heneghan, Justin Geoghegan, Kin Cheung Ng, Naomi Fearon, Krzysztof Kaseja, Maciej Kotowski, Tarig A Samarkandy, Adolfo Leyva-Alvizo, Lourdes Corzo-Culebro, Cunchuan Wang, Wah Yang, Zhiyong Dong, Manel Riera, Rajesh Jain, Hosam Hamed, Mohammed Said, Katia Zarzar, Manuel Garcia, Ahmet Gökhan Türkçapar, Ozan Şen, Edoardo Baldini, Luigi Conti, Cacio Wietzycoski, Eduardo Lopes, Tade ja Pintar, Jure Salobir, Cengiz Aydin, Semra Demirli Atici, An ılErgin , Huseyin Ciyiltepe, Mehmet Abdussamet Bozkurt, Mehmet Celal Kizilkaya, Nezihe Berrin Dodur Onalan, Mariana Nabila Binti Ahmad Zuber, Wei Jin Wong, Amador Garcia, Laura Vidal, Marc Beisani, Jorge Pasquier, Ramon Vilallonga, Sharad Sharma, Chetan Parmar, Lyndcie Lee, Pratik Sufi, Hüseyin Sinan, Mehmet Saydam" 0 7174 W3185414455.pdf 14 1 separator 0.9930752 ¶ 7174 7176 W3185414455.pdf 14 2 title 0.8915814 Author Contribution Concept: RS and KM 7176 7215 W3185414455.pdf 14 3 separator 0.783285 ¶ 7215 7217 W3185414455.pdf 14 4 text 0.86330336 Manuscript writing and reviewing: all authors 7217 7263 W3185414455.pdf 14 5 table 0.67814165 "¶ Figures: CL Analysis: RS, GR, and GG Data collection" 7263 7322 W3185414455.pdf 14 6 text 0.48032635 and 7322 7326 W3185414455.pdf 14 7 table 0.62250066 conduct: RS 7326 7338 W3185414455.pdf 14 8 separator 0.9839321 ¶ 7338 7340 W3185414455.pdf 14 9 title 0.9539643 Funding 7340 7348 W3185414455.pdf 14 10 text 0.8148004 "This study is funded by Bariatric Unit, University Hospital Birmingham NHS Foundation Trust." 7348 7443 W3185414455.pdf 14 11 separator 0.99104 ¶ 7443 7445 W3185414455.pdf 14 12 title 0.98913354 Declarations 7445 7458 W3185414455.pdf 14 13 separator 0.9320501 ¶ 7458 7460 W3185414455.pdf 14 14 title 0.9749056 Human and Animal Rights and Informed Consent 7460 7505 W3185414455.pdf 14 15 text 0.99633616 "All procedures per- formed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research commit- tee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study by the respective GENEVA collaborators." 7505 7910 W3185414455.pdf 14 16 separator 0.9951077 ¶ 7910 7912 W3185414455.pdf 14 17 title 0.97225726 Conflict of Interest 7912 7933 W3185414455.pdf 14 18 paratext 0.9440627 The authors declare no competing interests.4286 OBES SURG (2021) 31:4272–4288 7933 8012 W3185414455.pdf 14 0 title 0.92014897 CORRECTION 0 10 W2195000354.pdf 0 1 separator 0.9941139 ¶ 10 12 W2195000354.pdf 0 2 title 0.989215 Correction: Cysteine String Protein Limits 12 55 W2195000354.pdf 0 3 separator 0.91506064 ¶ 55 57 W2195000354.pdf 0 4 title 0.9740688 "Expression of the Large Conductance,Calcium-Activated K +(BK) Channel" 57 129 W2195000354.pdf 0 5 separator 0.9891612 ¶ 129 131 W2195000354.pdf 0 6 contact 0.6671415 Eva Ahrendt, Barry Kyle, Andrew P. Braun, Janice E. A. Braun 131 192 W2195000354.pdf 0 7 separator 0.9521581 ¶ 192 194 W2195000354.pdf 0 8 text 0.970545 "Fig 1C is incorrect as it shows the wrong actin blot. The authors have provided a corrected ver- sion of Fig 1 here." 194 313 W2195000354.pdf 0 9 separator 0.8777143 ¶ 313 315 W2195000354.pdf 0 10 text 0.9705309 "Additionally, there is a sentence missing from the caption for Fig 3 . Please see the complete, correct Fig 3 caption here. The missing sentence is highlighted in bold." 315 486 W2195000354.pdf 0 11 separator 0.96064556 ¶ 486 488 W2195000354.pdf 0 12 paratext 0.9675656 "PLOS ONE | DOI:10.1371/journal.pone.0140073 October 2, 2015 1/3 OPEN ACCESS" 488 566 W2195000354.pdf 0 13 separator 0.9486481 ¶ 566 568 W2195000354.pdf 0 14 paratext 0.74768907 Citation: Ahrend 568 585 W2195000354.pdf 0 15 bibliography 0.47376782 t 585 586 W2195000354.pdf 0 16 paratext 0.61105436 E, 586 589 W2195000354.pdf 0 17 bibliography 0.4884632 Kyle 589 594 W2195000354.pdf 0 18 paratext 0.5909897 B, 594 597 W2195000354.pdf 0 19 bibliography 0.38729885 Braun 597 603 W2195000354.pdf 0 20 paratext 0.6689151 AP , Braun JEA 603 618 W2195000354.pdf 0 21 separator 0.6174661 ¶ 618 620 W2195000354.pdf 0 22 paratext 0.95696735 "(2015) Correction: Cysteine String Protein LimitsExpression of the Large Conductance, Calcium-Activated K +(BK) Channel. PLoS ONE 10(10): e0140073. doi:10.1371/journal.pone.0140073" 620 805 W2195000354.pdf 0 23 separator 0.5615769 ¶ 805 807 W2195000354.pdf 0 24 paratext 0.9773053 Published: October 2, 2015 807 834 W2195000354.pdf 0 25 separator 0.79948086 ¶ 834 836 W2195000354.pdf 0 26 paratext 0.95957065 "Copyright: © 2015 Ahrendt et al. This is an open access article distributed under the terms of theCreative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited." 836 1107 W2195000354.pdf 0 0 separator 0.5939603 ¶ 1 2 W3033002491.pdf 1 1 paratext 0.49152642 "Ки ї вський ¶ нац ¶" 2 31 W3033002491.pdf 1 2 contact 0.4470294 і 31 33 W3033002491.pdf 1 3 paratext 0.35926178 33 34 W3033002491.pdf 1 4 contact 0.863903 "¶ ональний ¶ ун і верситет ¶ ¶ і мен і ¶ Тараса ¶ Шевченка ¶ ¶ Ihar Pushkin ¶ Ph . D . ¶ in History , ¶ Associate Professor , ¶ Department of Humanitarian Disciplines, ¶ Mogilev State University of Food Technologies , Belarus" 34 345 W3033002491.pdf 1 5 separator 0.85639507 "¶ ¶" 345 355 W3033002491.pdf 1 6 title 0.9870857 "THE ORIGINS OF CORRUPTION AND ABUSE OF POWER ¶ IN THE SOVIET PAST (EXAMPLE OF BELARUS)" 355 450 W3033002491.pdf 1 7 separator 0.9509873 "¶ ¶" 450 460 W3033002491.pdf 1 8 title 0.86842275 Abstract. 460 470 W3033002491.pdf 1 9 separator 0.815829 ¶ ¶ 470 476 W3033002491.pdf 1 10 text 0.9994043 "Using the example of the BSSR the article analyzes the historical background of corruption and abuse of power in modern society. Mistakes and shortcomings in the personnel policy of the party - state leadership of Soviet Belarus are shown. The failure of economic policy is stated to have been caused by a number of objective and subjective factors including imperfecti on of the personnel selection system, weakening of state and labor discipline, spread o f drunkenness and alcoholism, theft of state and public property. It is noted that in the 1970 - 1980s the number of embezzlement and misappropriations, the facts of using one's official position for personal enrichment did not steadily decline but increased , which resulted in great material damage to the national economy. A feature of that period was the fact that the facts of organized and corrupt crime were revealed in the USSR and Be larus." 476 1421 W3033002491.pdf 1 11 separator 0.8957914 ¶ 1422 1424 W3033002491.pdf 1 12 text 0.99848944 "The most notorious cases: the numeral facts of venality ¶ by the off icials of housing - departments of the Minsk district executive committee (1970), larcenies and abuses in the consumer cooperation in BSSR, especially in Orsha, where the high - level heads of Vitebsk Regional executive committee and Orsha district executive c ommittee as well as some other authority members were involved into official corruption (1973). The negative tendencies of abuse took place also among Party’s and Soviet leaders: in Vitebsk Region during 1975 - 1980 more than 100 authority members were penal ized for different cases of abuse; in 1981 138 heads were brought to responsibility." 1424 2141 W3033002491.pdf 1 13 separator 0.5943297 ¶ 2142 2144 W3033002491.pdf 1 14 text 0.9995765 "All these facts caused social tension in the society, disaffection of the population with the activities of the authorities, government and militia of the republic. As a r esult, the party - state leadership lost its authority, which along with economic problems and contention in society led to the collapse of the USSR. It is concluded that numerous facts of upward distortions and fraud bring into question the reliability of r eporting figures on the implementation of plans and programs for the economic development of the BSSR, and numerous modern conflicts in countries that formed the USSR arose in the Soviet past." 2144 2788 W3033002491.pdf 1 15 separator 0.946463 ¶ ¶ 2788 2794 W3033002491.pdf 1 16 text 0.36895558 Keywords: 2794 2804 W3033002491.pdf 1 17 separator 0.40236905 2804 2805 W3033002491.pdf 1 18 text 0.51108086 "¶ Belarus, historical background of corruption, person" 2805 2863 W3033002491.pdf 1 19 title 0.36715844 n 2863 2864 W3033002491.pdf 1 20 text 0.50396127 ¶ 2864 2866 W3033002491.pdf 1 21 title 0.34708247 el 2866 2869 W3033002491.pdf 1 22 text 0.45797965 "selection, organized and corrupt crime ." 2869 2912 W3033002491.pdf 1 23 separator 0.8371536 "¶ ¶ ¶" 2912 2926 W3033002491.pdf 1 24 text 0.9955316 "Сучаснаму грамадству ¶ неабходны аб’ектыўны аналіз, ¶ з пункту гледжання гістарычнага вопыту, кадравай палітыкі дзяржаўнай улады, шляхоў фарміравання, зместу і ўдасканалення кадравага патэнцыялу. Сёняшнія шматлікія ¶ канфлікты ў краінах, якія раней былі ў складзе СССР, маюць вытокі ў савецкім мінулым і маюць непасрэднае дачыненне да сістэмы падрыхтоўкі і падбору кіруючых кадраў." 2926 3341 W3033002491.pdf 1 25 separator 0.7442034 ¶ 3342 3344 W3033002491.pdf 1 26 text 0.961158 "Наша мэта прааналізаваць гістарычныя перадумовы карупцыі і злоўжыванняў уладаю на прыкладз е БССР у апошнія дзесяцігоддзі яе існавання (1970 – 1991) ." 3344 3509 W3033002491.pdf 1 27 separator 0.60102576 ¶ 3509 3514 W3033002491.pdf 1 28 text 0.5543321 ¶ 3514 3515 W3033002491.pdf 1 29 separator 0.7306353 ¶ 3517 3519 W3033002491.pdf 1 30 text 0.9973973 "Існаванне жорсткага парадку размеркавання кадраў у СССР прыводзіла да таго, што толькі сяброўства ў КПСС адкрывала дарогу спецыялісту для кар’ернага росту." 3519 3684 W3033002491.pdf 1 31 separator 0.6853018 ¶ 3685 3687 W3033002491.pdf 1 32 text 0.996986 "У савецкі час падбор кадраў ажыццяўляўся н а аснове так званых “ аб ’ектывак” і “гутарак” па інстанцыі (ад інспектара да начальніка аддзялення, упраўлення, намесніка міністра, міністра і г.д.)." 3687 3899 W3033002491.pdf 1 33 separator 0.64108145 ¶ 3900 3902 W3033002491.pdf 1 34 text 0.97687244 "У кандыдата , ¶ найперш , ¶ вызначалася такая якасць, як адданасць, вернасць справе партыі, а, па сутнасці, таму, ¶ хто запрашаў на службу. Прафе сіяналізм таксама быў патрэбен , але ён не быў на першым месцы ¶" 3902 4175 W3033002491.pdf 1 35 separator 0.8050163 ¶ 4177 4179 W3033002491.pdf 1 36 text 0.59664935 [2, с 4179 4185 W3033002491.pdf 1 37 paratext 0.43565488 . 4185 4186 W3033002491.pdf 1 38 text 0.5182953 70] 4186 4190 W3033002491.pdf 1 39 separator 0.37910607 ¶ 4190 4192 W3033002491.pdf 1 40 paratext 0.5045209 4192 4193 W3033002491.pdf 1 41 text 0.52603036 . 4193 4194 W3033002491.pdf 1 42 separator 0.98756427 ¶ ¶ 4195 4201 W3033002491.pdf 1 43 title 0.9863578 "Роля і значэнне КПСС у справе падрыхтоўкі, фарміравання і кіраванні кадрамі" 4201 4280 W3033002491.pdf 1 44 separator 0.86858636 ¶ ¶ 4280 4286 W3033002491.pdf 1 45 text 0.9761481 "ў 1970 – 1980 - х гг. раскрыты ў шэрагу публікацый савецкіх даследчыкаў. Галоўн ым у іх было тое, што задачы, якія ставіліся перад кадравым складам былі падпарадкаваны не законам развіцця эканомікі, а фарміраванню новага сацыялістычнага ладу пад кіраўніцтвам КПСС [3; 15; 21; 32] . ¶" 4286 4603 W3033002491.pdf 1 46 separator 0.61541414 ¶ 4606 4608 W3033002491.pdf 1 47 text 0.97215766 "Склад партыйна - савецкага кіраўніцтва і яго роля ў разв іцці эканомікі, сістэма падрыхтоўкі кадраў СССР і БССР у пэўныя гістарычныя перыяды закрануты ў працах, якія з’явіліся ў апошнія дзесяцігоддзі [5; 6; 12; 13; 34] . У сваіх публікацыях даследчыкі не ў поўным аб’ёме асвятлілі пралікі і недахопы ў кадравай пал ітыцы партыйна - дзяржаўнага кіраўніцтва савецкай Беларусі, у прыватнасці праявы карупцыі і злоўжыванняў уладаю." 4608 5074 W3033002491.pdf 1 48 separator 0.98142093 ¶ ¶ 5075 5081 W3033002491.pdf 1 49 title 0.8623903 "Правал эканамічнай палітыкі ў 1970 – ¶" 5081 5122 W3033002491.pdf 1 50 text 0.9907275 "1980 - я гг. быў выкліканы шэрагам аб’ектыўных і суб’ектыўных фактараў, у тым ліку недасканаласцю сістэмы падбо ру кадраў, іх закасцянеласцю, паслабленнем дзяржаўнай і працоўнай дысцыпліны, распаўсюджва - ннем п’янства і алкагаліз му, крадзяжоў дзяржаўнай і грамадскай уласнасці . Асаблівасцю перыяду стала і тое, што ў СССР і Беларусі былі выяўлены факты арганізаванай і карумпаванай злачыннасці, якія атрымалі шырокі грамадскі рэзананс." 5122 5608 W3033002491.pdf 1 51 separator 0.67120755 ¶ 5609 5611 W3033002491.pdf 1 52 text 0.98453206 "Найбольш гучныя справы: ш матлікія факты хабарніцтва сярод кіруючых работнікаў Краснадарскага краю (1982), у гандлёвай арганізацыі “Гастраном” Галоўнага ўпраўлення гандлю Масгарвыканкама (19 83), у Дзяржаўным камітэце СССР па эканамічных сувязях, Міністэрстве знешняга гандлю СССР пры заключэнні здзелак з замежнымі фірмамі (1986), злоўжыванні і парушэнні законнасці ў органах унутраных спраў Іркуцкай вобласці (1986) і іншыя [8, арк. 1; 4," 5611 6087 W3033002491.pdf 1 53 bibliography 0.5639832 арк 6087 6091 W3033002491.pdf 1 54 text 0.55865383 ". 1; 9," 6091 6104 W3033002491.pdf 1 55 bibliography 0.57149595 арк 6104 6108 W3033002491.pdf 1 56 text 0.6808412 . 1; 11, 6108 6116 W3033002491.pdf 1 57 bibliography 0.54222554 арк 6116 6120 W3033002491.pdf 1 58 text 0.72983956 ". 1 – 4]." 6120 6133 W3033002491.pdf 1 59 separator 0.9620889 ¶ 6134 6136 W3033002491.pdf 1 60 text 0.99753284 "У БССР гэта так званыя “мінская” і “аршанская” справы, у якія былі ўцягнуты як гаспадарнікі, так і партыйныя, савецкія работнікі, а таксама супрацоўнікі праваахоўнай сістэмы" 6136 6319 W3033002491.pdf 1 61 separator 0.51179206 6320 6321 W3033002491.pdf 1 62 text 0.8923158 "¶ [2, с. 71] ." 6321 6337 W3033002491.pdf 1 63 separator 0.7695783 ¶ ¶ 6338 6344 W3033002491.pdf 1 64 text 0.99720955 "У пачатку 1970 г. у БССР грамадства было ¶ ўзрушана выяўленымі шматлікімі фактамі хабарніцтва з боку чыноўнікаў жыллёвых аддзелаў райвыканкамаў Мінска. 04.01.1973 г. Вярхоўны суд БССР разгледзеў справу аб групе злачынцаў на чале з былым старшынёй Аршанскай райспажыў - кааперацыі М. Барадой, якая зай малася крадзяжом народнага дабра ў асабліва буйных памерах. Варта ўзгадаць, што напрыканцы 1960 - х гг. у СССР самай 96" 6344 6800 W3033002491.pdf 1 0 paratext 0.982511 "Vol.:(0123456789)1 3Cancer Causes Control (2017) 28:155–165 DOI 10.1007/s10552-016-0847-x" 0 92 W2584663609.pdf 0 1 separator 0.8966938 ¶ 92 94 W2584663609.pdf 0 2 title 0.7050145 ORIGINAL PAPER 94 109 W2584663609.pdf 0 3 separator 0.94803816 ¶ 109 111 W2584663609.pdf 0 4 title 0.98202825 Adjustment for tobacco smoking and alcohol consumption 111 166 W2584663609.pdf 0 5 separator 0.4628466 167 168 W2584663609.pdf 0 6 title 0.88019854 ¶ by simultaneous analysis of several types of cancer 168 221 W2584663609.pdf 0 7 separator 0.9828085 ¶ 221 223 W2584663609.pdf 0 8 contact 0.96084756 Tor Haldorsen1 · Jan Ivar Martinsen1 · Kristina Kjærheim1 · Tom K. Grimsrud1 223 300 W2584663609.pdf 0 9 separator 0.93889403 ¶ 302 304 W2584663609.pdf 0 10 paratext 0.9751951 "Received: 22 October 2015 / Accepted: 28 December 2016 / Published online: 2 February 2017 © The Author(s) 2017. This article is published with open access at Springerlink.com" 304 483 W2584663609.pdf 0 11 separator 0.97830236 ¶ 483 485 W2584663609.pdf 0 12 text 0.8612154 "0.72 (Fishermen), and an increase from 0.47 to 0.95 (For - estry workers)." 485 562 W2584663609.pdf 0 13 separator 0.9928899 ¶ 562 564 W2584663609.pdf 0 14 title 0.91407776 Conclusions 564 576 W2584663609.pdf 0 15 text 0.997235 "We consider the method useful for achiev - ing less confounded estimates of cancer risk in large cohort studies with no available information on smoking and alco-hol consumption." 576 757 W2584663609.pdf 0 16 separator 0.9962728 ¶ 757 759 W2584663609.pdf 0 17 table 0.96345824 "Keywords Alcohol drinking · Bias · Confounding factors · Epidemiological methods · Neoplasms · Tobacco smoking" 759 876 W2584663609.pdf 0 18 separator 0.9569553 ¶ 876 878 W2584663609.pdf 0 19 table 0.6070887 Abbrevi 878 886 W2584663609.pdf 0 20 title 0.4421894 ations 886 892 W2584663609.pdf 0 21 separator 0.57049227 ¶ 892 894 W2584663609.pdf 0 22 table 0.83975804 "SIR Standardised incidence ratio CI Confidence interval" 894 954 W2584663609.pdf 0 23 separator 0.99486315 ¶ 954 956 W2584663609.pdf 0 24 title 0.90612245 Introduction 956 969 W2584663609.pdf 0 25 separator 0.99209356 ¶ 969 971 W2584663609.pdf 0 26 text 0.99961114 "Tobacco smoking and alcohol consumption are related to several types of cancer [1] and constitute major risk fac-tors, alone or in combination, for many of them. Unevenly distributed consumption of tobacco and alcohol may, there-fore, seriously hamper the identification of other causal factors in the absence of appropriate confounder control, which may be the case in large studies based on linkage between census data and cancer registries [2, 3]. For dec- ades, methods for control of tobacco smoking in occupa-tional studies have been discussed [4–6] and evaluated [7–10]. Others have assessed the effect of controlling for tobacco and alcohol at the same time [11, 12]. The need for confounder control and bias assessment may vary according to scientific challenge or regulatory questions, but observed variation in cancer risk between regions, over time, and between populations does, indeed, demonstrate that the issue is of some concern [13–17]." 971 1931 W2584663609.pdf 0 27 title 0.9756096 Abstract Purpose 1931 1947 W2584663609.pdf 0 28 text 0.99707335 "Tobacco smoking and alcohol consumption are risk factors for several types of cancer and may act as confounders in aetiological studies. Large register-based cohorts often lack data on tobacco and alcohol. We present a method for computing estimates of cancer risk adjusted for tobacco and alcohol without exposure information.Methods We propose the use of confirmatory factor analysis models for simultaneous analysis of several can-cer sites related to tobacco and alcohol. In the analyses, the unobserved pattern of smoking habits and alcohol drinking is considered latent common factors. The models allow for different effects on each cancer site, and also for appro-priate latent site-specific factors for subgroup variation. Results may be used to compute expected numbers of can-cer from reference rates, adjusted for tobacco smoking and alcohol consumption. This method was applied to results from a large, published study of work-related cancer based on census data (1970) and 21 years of cancer incidence data from the national cancer registry.Results The results from our analysis were in accord- ance with recognised risks in selected occupational groups. The estimated relative effects from tobacco and alcohol on cancer risk were largely in line with results from Nordic reports. For lung cancer, adjustment for tobacco implied relative changes in SIR between a decrease from 1.16 to" 1947 3354 W2584663609.pdf 0 29 separator 0.98746455 ¶ 3355 3357 W2584663609.pdf 0 30 paratext 0.88453186 "Electronic supplementary material The online version of this article (doi:10.1007/s10552-016-0847-x) contains supplementary material, which is available to authorized users." 3357 3537 W2584663609.pdf 0 31 separator 0.91046906 ¶ 3537 3539 W2584663609.pdf 0 32 contact 0.995534 "* Tom K. Grimsrud tom.k.grimsrud@kreftregisteret.no" 3540 3596 W2584663609.pdf 0 33 separator 0.5530993 ¶ 3596 3598 W2584663609.pdf 0 34 contact 0.99041647 "1 Department of Research, Cancer Registry of Norway, Pb 5313, Majorstuen, 0304 Oslo, Norway" 3598 3693 W2584663609.pdf 0 0 title 0.99040395 Murine colonization andascension 0 32 W2622731166.pdf 9 1 separator 0.9952245 ¶ 32 34 W2622731166.pdf 9 2 text 0.99795306 "Deletion ofthepotoperon inencapsulated pneumococcal strain T4severely attenuates its ability tocolonize thenasopharynx ofamouse [17]. However, NESp Δpoth mutant PIP01 expresses higher levels oftheadhesive protein PspK and shows increased biofilm formation" 34 294 W2622731166.pdf 9 3 separator 0.9824734 ¶ 294 296 W2622731166.pdf 9 4 caption 0.9751388 "Fig4.Epithelia lcelladhesio nand invasion. Changes inepithelial celladhesion andinvasion were assessed using adhesion/ invasion assays with either Detroit 562(pharyn geal) orA549 (lung) human epithel ialcells. Epithelial cells were incubated with 107pneumococ ci andadhered orinternaliz edpneumococc iwere enumerat edonBA." 296 623 W2622731166.pdf 9 5 text 0.9223067 "Adhesion toDetroit 562was notsignificantl yaffected bytheabsence ofpotD inMNZ67 (A),butadhesio ntoA549 cells was significantl yincreased intheabsence ofpotD (B).Asignificant differenc ewas not observed between MNZ67 andPIP01 when examining Detroit 562orA549 cellinvasion (CandD).Allsamples were analyzed in triplica teandexperime ntswere performed atleast 3times. Error bars denote standard error ofthemean." 623 1036 W2622731166.pdf 9 6 separator 0.95319414 ¶ 1036 1038 W2622731166.pdf 9 7 paratext 0.9795205 https://d oi.org/10.1371 /journal.pone. 0179159.g004 1038 1091 W2622731166.pdf 9 8 separator 0.9849814 ¶ 1091 1093 W2622731166.pdf 9 9 title 0.9836298 Polyamin etransport andvirulence ofStreptoc occus pneumon iae 1093 1155 W2622731166.pdf 9 10 separator 0.8138628 ¶ 1155 1157 W2622731166.pdf 9 11 paratext 0.9805125 PLOS ONE |https://doi.or g/10.137 1/journal.po ne.01791 59 June 6,2017 10/19 1157 1234 W2622731166.pdf 9 0 paratext 0.9500304 "¶ ¶ Intern ational Journal of Telereha bilitation • telerehab. pitt.edu ¶ International Journal of Telerehabilitation • Vol. 14, No. 2 Fall 2022 • (10.5195/ijt.20 22.6492) 7" 1 203 W4311310868.pdf 6 1 separator 0.98987323 ¶ 204 206 W4311310868.pdf 6 2 title 0.9929762 Participants’ Response 207 230 W4311310868.pdf 6 3 separator 0.9949906 ¶ 232 234 W4311310868.pdf 6 4 text 0.9938728 "Following the intervention, participants were asked to provide their opinions regarding the program in a free -writing format. Some of the positive comments were as follows: “It was just as good online as in -person classes,” “It was nice to participate from home,” and “I learned how to use my smart phone.” Conversely, three respondents commented negatively due to poor connection: “It was hard to hear the sound.”" 234 660 W4311310868.pdf 6 5 separator 0.99699736 ¶ 662 664 W4311310868.pdf 6 6 title 0.9879424 Discussion 664 675 W4311310868.pdf 6 7 separator 0.99497324 ¶ 677 679 W4311310868.pdf 6 8 text 0.9995757 "This study aimed to (1) examine the feasibility of an online interactive exercise class for community -dwelling older adults and (2) preliminarily examine changes in physical activity and self -efficacy. Throughout the onl ine interactive exercise class, none of the participants experienced serious adverse events, and only minor problems associated with the online implementation of the intervention occurred. Additionally, the responses from participants were positive. The Wi lcoxon rank - sum test results showed significant improvements in the m -GES score and daily steps pre -intervention and post -intervention." 679 1311 W4311310868.pdf 6 9 separator 0.56541497 ¶ 1312 1314 W4311310868.pdf 6 10 text 0.9996029 "Furthermore, self -rated health was significantly greater in the maintained/improved group, based on the result of the ch i- square test." 1314 1454 W4311310868.pdf 6 11 separator 0.95241904 ¶ 1456 1458 W4311310868.pdf 6 12 text 0.9997639 "The average age of the participants was 76.9 years, approximately the same as that in previous studies of community - dwelling older adults (Nishiguch et al., 2015; Suzuki et al., 2004). Regarding frailty status, the proportion of participants in the robust group was similar to, that in the pre -frail group was lower than, and that in the frail group was higher than those in a previous study conducted in Japan using the same index (Yamada et al., 2015). Thus, the participants in this study were more likely to be frail than the general community -dwelling older population." 1458 2050 W4311310868.pdf 6 13 separator 0.98194265 ¶ 2052 2054 W4311310868.pdf 6 14 text 0.99973434 "A review of intervention studies on fall prevention in the community -dwelling older population reported a withdrawal rate of 9.1% –16% and a participation rate of over 80% after a 2–3-month intervention period (Nyman et al., 2012). Moreover, a previous study conducting online interactive exercise sessions for adults aged 25 –58 years reported a withdrawal rate of 50% (Santabarbara et al., 2022). An online intervention study of cance r patients an average age of 65 years, reported participation rates of 80% for one -on-one online sessions and 29% for group -based programs (Dennett et al. 2021). In this study, the withdrawal and participation rates were comparable to those of intervention studies conducted in community -dwelling older individuals, which is considered to be a good rate for online interventions. Additionally, no serious problems such as falls or physical illnesses occurred during the intervention period. Therefore, the progra m could be conducted safely. A few participants experienced poor communication conditions owing to audio and video problems. However, in most cases, the situation improved by simple on -the-spot operations and did not pose a major problem. During the implem entation stage, these technical problems were considered as issues that can be resolved by preparing the communication environment in advance. When participants provided free -writing comments about the program, the majority were positive. Based on the abov e findings, an online interactive program for community -dwelling older adults was considered feasible." 2054 3667 W4311310868.pdf 6 15 separator 0.99062335 ¶ 3669 3671 W4311310868.pdf 6 16 text 0.999277 "Results of pre - and post -intervention comparisons showed that the m -GES scores and daily steps significantly improved after the intervention. Further, th e maintained/improved group showed significantly greater post -intervention self -rated health." 3671 3927 W4311310868.pdf 6 17 separator 0.9676925 ¶ 3928 3930 W4311310868.pdf 6 18 text 0.99973965 "A previous study reported that an in -person exercise class for community -dwelling older adults significantly improved their self - efficacy for walking, falling, an d daily steps (Nishiguch et al., 2015; Suzuki et al., 2004). Furthermore, some participants reported that their self -rated health was maintained or increased after participating in the exercise classes (Barenfeld et al., 2018; Behm et al., 2014). In this s tudy, the exercise class was conducted in an online setting, and the results were similar to those obtained in -person. However, findings of reviews on step counts showed that continuous monitoring improved the step counts (Chaudhry et al., 2020). Therefore , the daily reporting of step count might have contributed to the improvement in the step count in this study, and this intervention should be closely examined." 3930 4791 W4311310868.pdf 6 19 separator 0.98715365 ¶ 4793 4795 W4311310868.pdf 6 20 text 0.9997479 "The m -FES score did not improve. In this study, the mean m -FES score was 130.5 pre -intervention . A previous study that measured the m -FES score in community -dwelling older individuals reported a mean value of 113.7 –123.1 (Quigley et al., 2014). The highest m -FES score was 140. It is possible that the participants in this study did not show a signifi cant improvement as their baseline m -FES score was high." 4795 5222 W4311310868.pdf 6 21 separator 0.978372 ¶ 5224 5226 W4311310868.pdf 6 22 text 0.9996229 "This study had several limitations. First, it was a before -and-after study and not a randomized controlled trial. Further investigation of the effectiveness of this intervention is required. Second, the intervention only lasted for a short time. The Ministry of Health, Labour and Welfare recommends that care prevention programs should be conducted for at least three months (Ministry of Health, Labour and Welfare, 2022a). Since this study was only cond ucted for a month, further study is required to determine the effectiveness of the program when performed over a longer period. In addition, this study required" 5226 5858 W4311310868.pdf 6 0 paratext 0.8499583 J. Y ang et al.: Measurement Report: Abundance and fractional solubilities of aerosol metals in urban Hong Kong 1407 0 116 W4304172135.pdf 4 1 separator 0.99590063 ¶ 116 118 W4304172135.pdf 4 2 caption 0.9958982 Figure 1. Seasonal average concentrations of total elemental metals in size-fractionated aerosols sampled by the MOUDI with the following 118 256 W4304172135.pdf 4 3 separator 0.80614704 ¶ 256 258 W4304172135.pdf 4 4 caption 0.9899961 "nominal cut points (Dp): 0.056 μm (size fraction 1), 0.1 μm (size fraction 2), 0.18 μm (size fraction 3), 0.32 μm (size fraction 4), 0.56 μm (size fraction 5), 1.0 μm (size fraction 6), 1.8 μm (size fraction 7), 3.2 μm (size fraction 8), 5.6 μm (size fraction 9), 10 μm (size fraction 10), and 18 μm (size fraction 11). The error bars represent 1 standard deviation of the seasonal average value." 258 659 W4304172135.pdf 4 5 separator 0.99390364 ¶ 659 661 W4304172135.pdf 4 6 paratext 0.53857064 pHD 661 665 W4304172135.pdf 4 0 paratext 0.9804278 "Oosthuizen et al. 10.3389/feduc.2024.1346907 Frontiers in Education 06 frontiersin.org" 0 88 W4396224570.pdf 5 1 title 0.9434456 TABLE 4 Diploma of Environmental Health student enrolments (2017–2023). 88 160 W4396224570.pdf 5 2 separator 0.9298887 ¶ 160 162 W4396224570.pdf 5 3 table 0.985569 "2017 2018 2019 2020 2021 2022 2023 Enrolled 5 5 9 16 29 25 11 Completed 1 1 3 5 11 * *2023 Completion data is not yet available." 162 297 W4396224570.pdf 5 4 separator 0.9959894 ¶ 297 299 W4396224570.pdf 5 5 title 0.8811826 "TABLE 5 Occupational Environmental Health and Safety degree enrolment data 2019–2023." 299 389 W4396224570.pdf 5 6 separator 0.88299704 ¶ 389 391 W4396224570.pdf 5 7 table 0.9944182 "Student category2019 2020 2021 2022 2023 Enrolled 2 11 9 15 24 Completed 2 2 0 3 1*" 391 482 W4396224570.pdf 5 8 separator 0.9329227 ¶ 482 484 W4396224570.pdf 5 9 text 0.920519 This number does not include 2023 Semester 2 data which is not yet available. 484 562 W4396224570.pdf 5 10 separator 0.9418056 ¶ 562 564 W4396224570.pdf 5 11 text 0.99916625 "This feedback attests to the university’s commitment to prepare its graduates to be able to secure employment in a range of working environments, training them to participate in employment interviews; and to practice professional conduct to enhance employability. All students studying the health science degree are required to undertake a minimum of 75 h of practicum with an employer in their area of study. It is worth noting that one student highlighted the assistance received to overcome a disability while learning. The lecturing staff across the OEHS major; with the support of the university’s Access and Inclusion team, was invaluable to this student while undertaking their studies at ECU." 564 1296 W4396224570.pdf 5 12 separator 0.99615073 ¶ 1296 1298 W4396224570.pdf 5 13 title 0.9859319 3 Discussion 1298 1311 W4396224570.pdf 5 14 separator 0.9962466 ¶ 1311 1313 W4396224570.pdf 5 15 text 0.99960756 "Edith Cowan University is a relatively new university that was established in 1991 in the Northern suburbs of the Perth Metropolitan area in Western Australia. As a new university in a relatively small city that has five universities (four public and one private) it was important for ECU to distinguish itself from the other well-established universities and ECU strives to provide industry-relevant teaching and research. ECU courses are developed with graduate employability as a key focus, and they are designed and regularly reviewed in consultation with industry. Teaching staff at ECU have extensive industry-based experience and networks. Work integrated learning placement opportunities, as well as fieldwork, and practicums are important aspects of ECU courses, and key to enable students to develop important employability skills to function effectively in the work environment ( Jackson, 2013a ,b). Such a student-centered approach, essential for student retention and success ( Taylor, 2013 ) has been rewarded as the university has received five-star ratings for undergraduate teaching quality for the last 17 years consecutively (Edith Cowan University, 2023 )." 1313 2541 W4396224570.pdf 5 16 separator 0.9807591 ¶ 2541 2543 W4396224570.pdf 5 17 text 0.99963105 "Environmental health officers provide a core public health service, and EH is a profession that is in high demand globally with a long- recognized skills shortage. Despite the demand, EH is not a popular career choice for school leavers and many people come into the profession later in life with several post graduate courses now on offer (Cromar, 2006 ; Dunn et al., 2018 ; Whiley et al., 2018 ; Oosthuizen et al., 2022 ). One of the first undergraduate degree courses that was developed at ECU was the BHlthSc and this course offered a minor in Environmental Health which was not accredited by EHA, and so did not lead to employment as an EHO. In the early years, the BHlthSc attracted more mature age students than school leavers and these students were studying to improve their employment prospects, so it was decided in 2006 to develop an accredited EH program in collaboration with EHA and the local EH fraternity. Although the previous versions of EH teaching had been delivered in the School of Biomedical and Health Sciences, by a relatively junior academic with an EH background, the degree was established in the School of Science. Many of the senior academics involved with the course design were environmental scientists, and they did not have a clear understanding of the role of EHOs as part of a Public Health team, this influenced the direction of the course, and it became too focused on environmental management, which meant that the course ended up being a 4-year long degree. In Australia, all undergraduate EH degrees are 3-year courses and so this placed the course at a distinct disadvantage, and it never was viable, producing only two graduates." 2543 4285 W4396224570.pdf 5 18 separator 0.9741237 ¶ 4286 4288 W4396224570.pdf 5 19 text 0.99971825 "This initiative consumed significant resources and the School of Science decided to archive it. The lesson learned from this failed initiative is the fact that EH academics were not driving the process and there were too many senior staff in power positions and with vested interests including irrelevant curriculum content, hence the course lost its Public Health focus. The course should have been located within the health discipline. It is an EHA accreditation requirement (Clause 4.6), that the coordinator of the course should be a qualified EHO and member of the association ( Environmental Health Australia, 2014 ), yet the only EHO on staff was employed in a different school." 4288 5004 W4396224570.pdf 5 20 separator 0.983843 ¶ 5004 5006 W4396224570.pdf 5 21 text 0.99963504 "The suite of EH courses that were developed since 2011 have been immersed in the EH profession from the very start and the program was developed to meet EHA accreditation requirements with significant input from a highly engaged industry consultative committee and several targeted focus group discussions. The W A Government Department of Health, and the Department of Water and Environmental Regulation were also part of the course development process, their inclusion from the outset ensured that the course met the statutory training requirements of the regulators." 5006 5600 W4396224570.pdf 5 22 separator 0.98717606 ¶ 5600 5602 W4396224570.pdf 5 23 text 0.99963206 "EH degrees offered at universities in Australia were targeted at high school students who were required to achieve the minimum Australian Tertiary Academic Ranking (ATAR) requirements to study at university, which is a number between 0.00 and 99.95 ( Universities Admission Centre, n.d. ). This number reflects a student’s relative position to others falling in the same age bracket. The major disadvantage of such a system is the possible exclusion of students who, due to other extenuating circumstances may fail to achieve the required score for university entry, yet given the opportunities, may well proceed to successfully complete any university course and enter the environmental health profession." 5602 6339 W4396224570.pdf 5 24 separator 0.9328754 ¶ 6339 6341 W4396224570.pdf 5 25 text 0.9994248 "Furthermore, the results of the focus group discussion with practicing EHOs indicated that several cadres employed as TOs in local government were already carrying out some EHO dues, albeit without formal qualifications not currently offered in Australia’s" 6341 6607 W4396224570.pdf 5 0 text 0.976397 "¶ Physical Layer Impairments ( PLIs ): the Amplified Spontaneous Emission ( ASE ) noise, Cross -Phase Modulation (XPM), Four -Wave Mixing (FWM), and dispersion. The ASE noise, XPM and FWM gen erate the beat noise (i.e., crosstalk) terms at th e receiver. Further, assuming that the signal power for bit ‘0’ is zero, the BER and the noise powers are given as ¶ " 1 389 W2620132349.pdf 1 1 math 0.8100156 "¶           11 0 2 2 41  T S T I IerfcIerfc BER , (1) where ¶ 1 00 1 1 0      S STI II , (2) and ¶" 389 565 W2620132349.pdf 1 2 text 0.4819466 1 565 567 W2620132349.pdf 1 3 math 0.5102435 SI 567 569 W2620132349.pdf 1 4 text 0.63274145 "and 0SI are the signal currents due to the reception of bit ‘1’ and ‘0’ respectively. Further, ¶" 570 676 W2620132349.pdf 1 5 math 0.8445432 "¶ 2 2 2 22 2 2 2 2) 1 ( Thermal XPM signal FWM signal FWM ASEASE ASE signal ASE shot ASE signal                     (3) and ¶ 2 22 2 2) 0 ( Thermal FWM ASEASE ASE shot ASE          , (4) ¶" 678 928 W2620132349.pdf 1 6 text 0.5672317 where in (3) and (4), 928 950 W2620132349.pdf 1 7 math 0.47502285 950 951 W2620132349.pdf 1 8 text 0.48035392 ¶ 2 951 954 W2620132349.pdf 1 9 math 0.5169489 ¶ 954 956 W2620132349.pdf 1 10 text 0.7033418 "Thermal , 2 shot , 2 signal are the thermal noise, the shot noise, and the signal noise variance respectively, 2 2 2, , FWM ASE ASE ASE shot ASE      are the ASE - shot noise, ASE -ASE and ASE -FWM beat noise respectively, and 2 2 2, ,XPM signal FWM signal signal ASE      are the ASE -signal, signal -FWM and signal -XPM beat noise respectively." 956 1351 W2620132349.pdf 1 11 separator 0.98325336 ¶ 1353 1355 W2620132349.pdf 1 12 text 0.9861616 "Further , the design steps in our work are detailed as follows: ¶ 1) Initially, the k-shortest paths (k-SPs) between every network topology s-d pair are determined . 2) Then, over the possible routes, for a candidate lig htpath, the BER is evaluated with a certain format of modulation ; hence, it is check ed whether the evaluated BER is less than the specified threshold or not. 3) The above step is repea ted for all the line rates, hence, based on the BER threshold , specific line rate feasibility (or viability) for every s-d pair is ensured. 4) For few s-d pairs which are distant apart, and have non - viable higher line rates, the above p rocedure is repeated with the appropriate modulation format, whose extended reach makes few more lightpaths feasible over the higher line rates, which were infeasible with the previously used format owing to constraint set by the BER threshold . 5) With this pre -processed data as the input, a mathematical formulation of the problem is developed in the form of an MILP , which is detailed as follows:" 1355 2474 W2620132349.pdf 1 13 separator 0.9636762 ¶ ¶ 2476 2482 W2620132349.pdf 1 14 math 0.54700893 "Input : ) , (" 2482 2499 W2620132349.pdf 1 15 text 0.534888 "E V G : Network topology comprising of a set of V nodes and a set of E links;  d s T : Matrix consisting of the traffic having the total Gbps requests of d s between a n s-d pair" 2499 2704 W2620132349.pdf 1 16 math 0.48276228 ";  kR R R R ,...... ," 2704 2731 W2620132349.pdf 1 17 text 0.79815394 "2 1 : Line rate a vailable set; kTP : Transponder (with rate kR ) cost; A : Cost of an amplifier ; n mA : On a fiber, the amplifier numbers over the link with nodes m and n. For a span distance L = 80 km bet ween adjacent amplifiers (EDFAs), the amount of EDFAs for the link of a fiber is given as   2 1   L L Amnn m ; where, mnL denotes length of span of the f iber between m and n." 2731 3162 W2620132349.pdf 1 18 separator 0.7019958 ¶ 3163 3165 W2620132349.pdf 1 19 text 0.4490689 pC 3165 3168 W2620132349.pdf 1 20 table 0.3826719 ¶ 3168 3170 W2620132349.pdf 1 21 text 0.47179952 : Electronic processing ( 3170 3196 W2620132349.pdf 1 22 table 0.4483973 per Gbps) cost i.e. 3196 3216 W2620132349.pdf 1 23 text 0.4178925 , 3216 3217 W2620132349.pdf 1 24 table 0.45701554 cost of 3217 3225 W2620132349.pdf 1 25 text 0.42057845 OEO 3225 3229 W2620132349.pdf 1 26 table 0.44706222 ¶ conversion 3230 3243 W2620132349.pdf 1 27 text 0.37622118 . 3243 3245 W2620132349.pdf 1 28 table 0.63049304 "¶ j il : Lightpath length in km between a n s–d pair; n ml : Link" 3246 3321 W2620132349.pdf 1 29 text 0.48538426 ( 3321 3323 W2620132349.pdf 1 30 table 0.5325872 physical) between m and n 3323 3348 W2620132349.pdf 1 31 text 0.4559106 ; 3348 3349 W2620132349.pdf 1 32 table 0.5183157 ¶ W ¶ 3351 3357 W2620132349.pdf 1 33 text 0.4670472 : 3357 3360 W2620132349.pdf 1 34 table 0.4817493 Maximum amount(s 3360 3376 W2620132349.pdf 1 35 text 0.48330924 ) 3376 3377 W2620132349.pdf 1 36 table 0.5141367 of the wavelength (s) on 3377 3402 W2620132349.pdf 1 37 text 0.4927017 3402 3403 W2620132349.pdf 1 38 table 0.46576986 a link 3403 3410 W2620132349.pdf 1 39 text 0.4090309 ";   W,....2" 3410 3426 W2620132349.pdf 1 40 math 0.41016018 , 3426 3428 W2620132349.pdf 1 41 text 0.38644803 1 3428 3432 W2620132349.pdf 1 42 math 0.42137527 ¶ 3432 3435 W2620132349.pdf 1 43 text 0.5669826 "; B : BER threshold which is set to 10-12. Any light path with a BER greater than the threshold is rejected; k j i BER : BER of a lightpath between an s–d pair " 3435 3611 W2620132349.pdf 1 44 math 0.4434221 i 3611 3612 W2620132349.pdf 1 45 text 0.4502288 - 3612 3613 W2620132349.pdf 1 46 math 0.4620024 j 3613 3614 W2620132349.pdf 1 47 text 0.46688595 at a 3614 3619 W2620132349.pdf 1 48 math 0.4757871 3620 3621 W2620132349.pdf 1 49 text 0.5049482 ¶ line rate 3621 3632 W2620132349.pdf 1 50 math 0.5049154 3633 3634 W2620132349.pdf 1 51 text 0.43339726 ¶ 3634 3635 W2620132349.pdf 1 52 math 0.445749 kR and 3635 3642 W2620132349.pdf 1 53 text 0.4937021 a wavelength 3642 3655 W2620132349.pdf 1 54 math 0.713194 "¶  ;  ,),, ( else 0for 1 k j iB BER bijk ijk    ;" 3655 3734 W2620132349.pdf 1 55 text 0.8359624 "denotes the lightpath feasibil ity based on the threshold BER. Hence, ijkb determines the feasibility of a lightpath between a node (s) pair over a specific wavelength and bit rate." 3734 3930 W2620132349.pdf 1 56 separator 0.747928 ¶ 3932 3934 W2620132349.pdf 1 57 text 0.46010232 n mP 3934 3939 W2620132349.pdf 1 58 table 0.42659903 ¶ 3939 3941 W2620132349.pdf 1 59 text 0.48511073 : Lightpath (s) 3941 3957 W2620132349.pdf 1 60 table 0.44218612 "set passing through the link n ml " 3957 3994 W2620132349.pdf 1 61 text 0.40335807 . 3994 3995 W2620132349.pdf 1 62 separator 0.48568687 ¶ ¶ 3996 4002 W2620132349.pdf 1 63 text 0.54928446 Variables: 4002 4013 W2620132349.pdf 1 64 table 0.46926725 ¶ 4015 4017 W2620132349.pdf 1 65 text 0.4959652 4017 4018 W2620132349.pdf 1 66 table 0.42545 k 4018 4021 W2620132349.pdf 1 67 text 0.435249 j 4021 4022 W2620132349.pdf 1 68 table 0.41777578 iX 4022 4025 W2620132349.pdf 1 69 text 0.54382074 "¶ : Lightpath (s) number(s) at a rate kR and a wavelength  between the nodes i- j; d s j iF : Between s-d, traffic which is routed on a lightpath i- j. jE " 4025 4207 W2620132349.pdf 1 70 table 0.48233333 ¶ 4207 4208 W2620132349.pdf 1 71 text 0.5992898 ": Variable (integer) which denotes the data amount that is carried by the lightpaths ending at node j." 4208 4316 W2620132349.pdf 1 72 separator 0.9656966 ¶ ¶ 4317 4323 W2620132349.pdf 1 73 text 0.7251131 Problem formulation: 4323 4344 W2620132349.pdf 1 74 separator 0.8675428 ¶ 4346 4348 W2620132349.pdf 1 75 text 0.979388 "Minimize the overall network cost which consists of (i) number of transponders and the fiber amplifiers, and (ii) the electro nic processing used for setting up the multi -hop connections (i.e., the s–d connections whose establishment occurs over many i.e., multiple lightpaths. ), which is mathematically given as follows:" 4348 4687 W2620132349.pdf 1 76 separator 0.49226457 ¶ 4689 4691 W2620132349.pdf 1 77 math 0.87837434 "       jp jn mmn mn j i kk k j i C EF A A TP X Minimize" 4691 4766 W2620132349.pdf 1 78 text 0.4467627 "Objective " 4766 4778 W2620132349.pdf 1 79 math 0.41056472 , 4778 4779 W2620132349.pdf 1 80 text 0.53051674 : 4779 4780 W2620132349.pdf 1 81 math 0.507863 ¶ 4780 4782 W2620132349.pdf 1 82 text 0.51377547  4782 4785 W2620132349.pdf 1 83 math 0.53424126 ¶ 4785 4787 W2620132349.pdf 1 84 text 0.5281747 (5) 4789 4793 W2620132349.pdf 1 85 separator 0.4646726 4794 4795 W2620132349.pdf 1 86 text 0.9181096 ¶ The objective function i n (5) is constrained by: 4795 4846 W2620132349.pdf 1 87 separator 0.89768946 ¶ 4848 4850 W2620132349.pdf 1 88 paratext 0.9551017 "International Journal of Advances in Telecommunications, Electrotechnics, Signals and Systems Vol. 6, No. 2 (2017) 62" 4850 4972 W2620132349.pdf 1 0 paratext 0.8060741 "Review of: ""Investigation of the properties of the composition obtained based on mixtures of polyvinyl chloride""" 0 114 W4362604491.pdf 0 1 separator 0.9818119 ¶ 114 116 W4362604491.pdf 0 2 contact 0.41097054 Omdeo Gohatre 116 130 W4362604491.pdf 0 3 separator 0.98961157 ¶ 130 132 W4362604491.pdf 0 4 text 0.7649768 Potential competing interests: 132 163 W4362604491.pdf 0 5 separator 0.5796835 ¶ 163 165 W4362604491.pdf 0 6 text 0.9948238 No potential competing interests to declare. 166 211 W4362604491.pdf 0 7 separator 0.6016842 ¶ 211 213 W4362604491.pdf 0 8 text 0.99867946 "The author should explain what exact SKEPT and SREPT. Even not mention the full form at the starting of the manuscript. The abstract of manuscript is not clear and written in poor English. The objective of the current study not defined clearly in the abstract. Introduction part is too small and looking that author has not done in detailed study or survey of the current research topic." 213 610 W4362604491.pdf 0 9 separator 0.82148886 ¶ 610 612 W4362604491.pdf 0 10 text 0.9895708 "In my opinion the current manuscript “Investigation of the properties of the composition obtained based on mixtures of polyvinyl chloride” should not be consider for publication in its current form." 612 819 W4362604491.pdf 0 11 separator 0.9764068 ¶ 819 821 W4362604491.pdf 0 12 paratext 0.97621816 "Qeios, CC-BY 4.0 · Review, April 5, 2023" 821 869 W4362604491.pdf 0 13 separator 0.5561337 ¶ 869 871 W4362604491.pdf 0 14 paratext 0.98193145 Qeios ID: A8UHHA · https://doi.org/10.32388/A8UHHA 871 926 W4362604491.pdf 0 15 separator 0.61449456 ¶ 926 928 W4362604491.pdf 0 16 paratext 0.92273694 "1 /" 928 934 W4362604491.pdf 0 17 separator 0.8737613 ¶ 934 936 W4362604491.pdf 0 18 paratext 0.5406816 1 936 938 W4362604491.pdf 0 0 paratext 0.79836065 2 Journal of Investigative Medicine High Impact Case Reports 0 60 W2141481800.pdf 1 1 separator 0.990397 ¶ 60 62 W2141481800.pdf 1 2 text 0.9991393 "proliferative activity >10%. She was classified as standard risk for recurrence. Analysis of molecular markers was not done as its role was not established then. Postoperatively she received 36 Gy craniospinal radiation with an 18 Gy boost to the posterior fossa followed by adjuvant chemotherapy with carboplatin and etoposide. She did well for 10 years until she presented with generalized weakness and hoarseness. ENT evaluation demonstrated left true vocal cord paralysis. Computed tomography (CT) showed a 4.2 × 6.8 cm infiltrat-ing mass that surrounded and extrinsically compressed the left main pulmonary artery, left mainstem bronchus, and dis-tal trachea. The mass was inseparable from the aortic arch and involved the left hilar, subcarinal, pretracheal, and right paratracheal nodes (Figure 1). Positron emission tomogra-phy (PET)/CT showed 18FDG-avid masses involving the left lower lobe, left hilum, and mediastinum, and bilateral supra-clavicular lymph nodes. Excisional biopsy of a left supracla-vicular lymph node showed metastatic high-grade round blue cell malignant neoplasm positive for GFAP, NSE, and synaptophysin (Figure 2). After comparison to the original biopsy, a diagnosis of metastatic medulloblastoma was ren-dered. MRI of the head and spine showed no evidence of tumor or metastases in the central nervous system. She was treated with 3 cycles of weekly cisplatin 30 mg/m 2 and irino- tecan 65 mg/m2 after which PET scan showed a compete response. This was followed by high-dose carboplatin, thio-tepa, and etoposide conditioning followed by autologous stem cell transplant. She tolerated the treatment well and achieved a complete response. Two years later, PET/CT showed increased activity in the mediastinum and supracla-vicular lymph nodes. A biopsy confirmed relapse. She was treated with 6 cycles of carboplatin AUC 4 and gemcitabine 1000 mg/m 2 every 21 days. After showing an initial response to the chemotherapy, PET/CT showed tumor progression in the aforementioned sites. She was treated with 50.4 Gy intensity modulated radiotherapy. The mass showed a partial response that has been stable for 4 months." 62 2230 W2141481800.pdf 1 3 title 0.9393052 Discussion 2230 2240 W2141481800.pdf 1 4 separator 0.9952724 ¶ 2240 2242 W2141481800.pdf 1 5 text 0.9854147 "Medulloblastomas are malignant brain tumors arising from primitive neuroepithelial cells in the cerebellum. They are the most common malignant brain tumor of childhood with peak incidence between 5 and 9 years and a much smaller peak between 20 and 24 years of age. 3,4 Seventy percent are diagnosed before 20 years of age and rare after the fourth decade, consistent with their embryonal origin. 3,4 Since the leptomeninges are involved in 20% to 25% of patients, both spinal MRI and cerebrospinal fluid (CSF) analysis is recom-mended in all patients, as the results can be discordant." 2242 2839 W2141481800.pdf 1 6 separator 0.8189242 ¶ 2839 2841 W2141481800.pdf 1 7 text 0.6469787 5 2841 2843 W2141481800.pdf 1 8 separator 0.9533319 ¶ 2844 2846 W2141481800.pdf 1 9 text 0.61352676 Multimodality therapy with resection followed by radiation to the primary site and the craniospinal axis, and systemic chemotherapy is standard. 2846 2991 W2141481800.pdf 1 10 separator 0.90261114 ¶ 2991 2993 W2141481800.pdf 1 11 text 0.9324122 "6 Treatment of adults is modeled on protocols used in children as there are no prospective studies in adults owing to the rarity of the tumor." 2993 3139 W2141481800.pdf 1 12 separator 0.7622955 ¶ 3139 3141 W2141481800.pdf 1 13 text 0.9885961 "In one series by Pobereskin and Treip on 12 adult patients, all but one—who had bone metastases—experienced either a local recurrence or craniospinal metastases. 7 In another study by Ang et al on 25 patients, they had either a local recurrence or metastases within the neuraxis. 8 In a third series of 14 adult patients, the recurrence was primarily in the central nervous system (CNS) apart from bone or bone marrow metastases observed in 3 patients. 9 Similarly, in another series of 42 patients by Prados et al, there were no extraneu-ral metastases apart from 2 patients who developed bone lesions." 3141 3763 W2141481800.pdf 1 14 separator 0.5805414 ¶ 3763 3765 W2141481800.pdf 1 15 text 0.98548985 "10 Extraneural metastases are exceedingly rare in lit- erature. We came across one case with widespread metastatic disease and local recurrence that recurred in the pelvic lymph nodes and soft tissues. 11 We have not come across any adult medulloblastoma patient with mediastinal metastases like our patient." 3765 4081 W2141481800.pdf 1 16 separator 0.95443845 ¶ 4081 4083 W2141481800.pdf 1 17 text 0.99815893 "Since spinal leptomeninges can be involved in 20% to 25% of patients, both MRI spine and CSF analysis is recom-mended in all patients at diagnosis, as the results can be dis-cordant." 4083 4269 W2141481800.pdf 1 18 separator 0.9965826 ¶ 4269 4271 W2141481800.pdf 1 19 title 0.9839215 5 Multimodality therapy with maximal safe resection 4271 4323 W2141481800.pdf 1 20 separator 0.8779819 ¶ 4324 4326 W2141481800.pdf 1 21 text 0.99972785 followed by radiation to the primary site and the craniospinal axis and systemic chemotherapy is the standard treatment in children. Neurologic and endocrine complications are limit-ing factors for higher radiation therapy doses, especially in children less than 3 years old. For children more than 3 years of age with complete resection of tumor, 23.4 Gy craniospi-nal irradiation followed by a posterior fossa boost of 32.4 Gy is the standard recommendation. 4326 4787 W2141481800.pdf 1 22 separator 0.7696091 ¶ 4787 4789 W2141481800.pdf 1 23 text 0.9247809 "6 Treatment in adults is modeled on protocols in older children as there are no ran-domized prospective studies in this age group owing to the rarity in this population. In adults with no evidence of resid-ual disease postsurgery or distant metastases, the role of che-motherapy is controversial as they can tolerate higher doses of radiation therapy. Late relapses are more frequent in adults compared to children. 2,12,13 There is no standard treatment for adult patients who suffer a relapse. Options include surgical resec-tion where possible, followed by chemotherapy and/or" 4789 5382 W2141481800.pdf 1 24 separator 0.98519146 ¶ 5383 5385 W2141481800.pdf 1 25 caption 0.994401 Figure 1. CT scan showing the infiltrating mediastinal mass. 5385 5446 W2141481800.pdf 1 0 text 0.9579318 "other social scientists in dherse disciplines in African society, this book raises many interrogations ""hich should provide sustained socio-historical debates here in Africa and in the African Diaspora." 0 208 W4385980047.pdf 4 1 separator 0.8474307 ¶ 59 209 214 W4385980047.pdf 4 0 paratext 0.6620718 CARDIO VASCULAR MEDICINE 0 25 W45258012.pdf 0 1 separator 0.47141758 25 26 W45258012.pdf 0 2 paratext 0.5478938 ¶ 26 27 W45258012.pdf 0 3 title 0.5828856 Research in 27 39 W45258012.pdf 0 4 paratext 0.66732496 ¶ 39 41 W45258012.pdf 0 5 title 0.640511 Official Journal of Rajaie Cardiovascular Medical and Research Center 41 111 W45258012.pdf 0 6 separator 0.93160546 ¶ 111 113 W45258012.pdf 0 7 title 0.9869706 Subacute Myocardial Rupture Following Tirofiban Treatment 113 171 W45258012.pdf 0 8 separator 0.9897901 ¶ 171 173 W45258012.pdf 0 9 contact 0.99391085 Özgür Çiftçi 1, Murat Günday 2, *, Tonguç Saba 2, Mehmet Özülkü 2 173 239 W45258012.pdf 0 10 separator 0.581321 ¶ 239 241 W45258012.pdf 0 11 contact 0.982259 "1 Department of Cardiology , Faculty of Medicine, Baskent University , Ankara, Turkey 2 Department of Cardiovascular Surgery , Faculty of Medicine, Baskent University , Ankara, Turkey" 241 427 W45258012.pdf 0 12 separator 0.87067187 ¶ 427 429 W45258012.pdf 0 13 contact 0.99473643 "*Corresponding author: Murat Günday , Baskent Universitesi Konya Hastanesi, Kalp ve Damar Cerrahisi Bölümü, Hocacihan Mah. Saray Cad. No : 1, Selçuklu, Konya, Turkey . Tel: +90-3122126868, Fax: +90-3122237333, E-mail: gundaymurat@yahoo.com" 429 672 W45258012.pdf 0 14 separator 0.9935081 ¶ 672 674 W45258012.pdf 0 15 title 0.98137033 ABSTRACT 674 683 W45258012.pdf 0 16 separator 0.9960774 ¶ 683 685 W45258012.pdf 0 17 text 0.99962395 "A 74-year-old male patient was admitted to our emergency department with post-MI angina. On account of the anginal complaint that continued for three days, a coronary artery angiography was undertaken. A percutaneous transluminal coronary angioplasty was performed, followed by the implantation of a coronary stent, and coronary perfusion (TIMI-3) was achieved in the left anterior descending artery . Medical treatment (with acetylsalicylic acid, clopidogrel, metoprolol, atorvastatin and enoxaparine) and tirofiban infusion were duly administered in the coronary care unit. After twenty-four hours, however, acute dyspne, hypotension and tachycardia developed, making it necessary to perform an echocardiography . Since the echocardiography revealed a frank pericardial effusion, the patient was immediately taken to the operation room. The ventricular free wall rupture was repaired with Surgicel, which was prepared in three layers and fixed to the myocardium by tissue glue; cardiopulmonary bypass was not used. To our knowledge, our study constitutes the first case report of a tirofiban-induced free wall rupture." 685 1809 W45258012.pdf 0 18 separator 0.9948644 ¶ 1809 1811 W45258012.pdf 0 19 paratext 0.54824996 Keywords: 1811 1821 W45258012.pdf 0 20 title 0.46144238 Tirofiban 1821 1831 W45258012.pdf 0 21 paratext 0.43910304 ; Rup 1831 1836 W45258012.pdf 0 22 title 0.42089275 ture 1836 1840 W45258012.pdf 0 23 paratext 0.4747409 ; Emergencies 1840 1853 W45258012.pdf 0 24 separator 0.99110645 ¶ 1853 1855 W45258012.pdf 0 25 paratext 0.77233946 Copyright © 2013, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Published by Kowsar Corp. 1855 2001 W45258012.pdf 0 26 separator 0.9568949 ¶ 2001 2003 W45258012.pdf 0 27 paratext 0.91255903 Article type: Case Report; Received: 18 Dec 2012; Revised: 08 Jan 2013; Accepted: 26 Feb 2013; Epub: 31 Jul 2013; Ppub: 10 Aug 2013 2003 2138 W45258012.pdf 0 28 separator 0.9281174 ¶ 2138 2140 W45258012.pdf 0 29 text 0.83871543 "Implication for health policy/practice/research/medical education: This study is going to be considered in the use of tirofiban." 2140 2272 W45258012.pdf 0 30 separator 0.7801311 ¶  2272 2276 W45258012.pdf 0 31 paratext 0.80668956 Please cite this paper as: 2276 2302 W45258012.pdf 0 32 separator 0.895999 ¶ 2302 2304 W45258012.pdf 0 33 bibliography 0.9800883 "Çiftçi Ö, Günday M, Saba T, Özülkü M. Subacute Myocardial Rupture Following Tirofiban Treatment. Res Cardiovasc Med.2013;2(3):149- 51. DOI: 10.5812/cardiovascmed.10065" 2304 2474 W45258012.pdf 0 34 separator 0.9873239 ¶ 2474 2476 W45258012.pdf 0 35 paratext 0.7537405 Copyright © 2013, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran; Published by Kowsar Corp. 2476 2623 W45258012.pdf 0 36 separator 0.87263083 ¶ 2623 2625 W45258012.pdf 0 37 paratext 0.9602294 "This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which per - mits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.1." 2625 2905 W45258012.pdf 0 38 title 0.9445119 Introduction 2905 2918 W45258012.pdf 0 39 separator 0.9961122 ¶ 2918 2920 W45258012.pdf 0 40 text 0.9996624 "The left ventricular free wall rupture, although rarely encountered, constitutes one of the most fatal compli- cations of acute myocardial infarction. Surgical repair is mandatory , even though operative mortality is high. Ear-ly diagnosis and surgical repair are crucial in treatment. However, it remains controversial which is the most suit-able method of surgical management. Glycoprotein IIb/IIIa antagonists like abciximab, eptifibatide and tirofi -ban, the last a nonpeptide tyrosine derivative (Aggrastat, Merck & Co), have generally demonstrated good clinical benefits and safety profiles in acute coronary syndrome. But we present in this study a complication of subacute myocardial infarction, involving ventricular free wall rupture that developed after the administration of tiro - fiban. Surgical treatment was administered through the implantation of Surgicel (Ethicon, Inc., a Johnson & John - son company; Somerville, NJ), which was fixed in place with tissue glue." 2920 3911 W45258012.pdf 0 0 separator 0.5385543 ¶ 1 2 W4313574702.pdf 2 1 paratext 0.9715482 15 | Dakwah | Vol 5 | No. 2 | 2022 2 37 W4313574702.pdf 2 2 separator 0.9741722 ¶ 39 41 W4313574702.pdf 2 3 title 0.98113567 ABSTRAK 42 50 W4313574702.pdf 2 4 separator 0.995399 ¶ 52 54 W4313574702.pdf 2 5 text 0.9518418 "Tujuan Penelitian: Penelitian ini bertujuan untuk mengungkap model da’wah bil ihsan. Sebuah model da’wah yang didasari dengan ilmu, kesabaran dan kecintaan . Metode Penelitian : Kualitatif." 54 251 W4313574702.pdf 2 6 title 0.7789643 Hasil Penelitian 251 268 W4313574702.pdf 2 7 text 0.759279 : 268 270 W4313574702.pdf 2 8 separator 0.8103293 ¶ 271 273 W4313574702.pdf 2 9 text 0.9990713 "Pertama: Da’wah bil ihsan mengedepankan ilmu, kecintaan dan kelembut an. Sehingga yang asalnya benci berubah menjadi cinta. Kata ihsan sendiri disebutkan dalam al -Qur’an di beberapa tempat. Kedua dilakukan dengan cara bil ihsan, dengan cara yang paling baik. Karena hal ini penting untuk dilakukan oleh juru da’wah. Keberhasilah da’wah atau seruan sangat tergantung sejauh mana para juru da’ wah memahami seluk -beluk yang berkaitan dengan da’ wahnya. Para ulama menyebutkan ada beberapa un sur pokok dalam melaks anakan da’ wah, ant ara lain; Juru da’wah, objek da’wah, materi da’ wah dan u slub da’ wah atau metode atau juga cara da’ wah.Unsur - unsur pokok da’ wah yang disebutkan itu merupakan sesuatu yang amat penting dalam menunjang keberhasilan da’ wah yang disampaikan." 273 1087 W4313574702.pdf 2 10 separator 0.94989836 ¶ 1088 1090 W4313574702.pdf 2 11 text 0.9949178 "Terkadang da’ wah yang tidak berhasil itu, salah satu sebabnya adalah kurangnya juru da’wah memperhatikan unsur -unsur dan pokok da’ wah di atas tadi. Ketiga: memahami dan memperhatikan empat bekal juru da’ wah yang harus diperhatikan. Keempat: Memperhatikan o byek da’wah , dengan siapa dia berhadapan, orang berilmu atau kah orang yang tidak berilmu. Kelima: Hendaknya memakai metode da’wah yang benar. Keenam: memperhatikan lima sumber da’wah. Ketujuh: Memperhatikan prinsip - prinsip da’wah. Kedelapan: Dilakukan dengan lembut d an bijaksana , itu lah da’wah bil ihsan." 1090 1691 W4313574702.pdf 2 12 separator 0.99202716 ¶ 1693 1695 W4313574702.pdf 2 13 title 0.5845838 Kata Kunci 1695 1706 W4313574702.pdf 2 14 text 0.832632 : Da’wah bil Ihsan , konsep, metode, aplikasi 1706 1753 W4313574702.pdf 2 15 separator 0.99575084 ¶ ¶ 1756 1762 W4313574702.pdf 2 16 title 0.9891905 PENDAHULUAN 1762 1774 W4313574702.pdf 2 17 separator 0.99587524 ¶ 1777 1779 W4313574702.pdf 2 18 text 0.99498516 "Da’wah bil ihsan merupakan pilar terpenting dalam da’wah Islam. Da’wah yang dilandasi dengan ilmu, kesabaran, hikmah dan kelembutan. Kalimat ihsan disebutkan dalam al -Qur’an dalam beberapa tempat, diantaranya dalam al -Baqarah ayat 178, 229, an -Nahl ayat 90.1" 1779 2052 W4313574702.pdf 2 19 separator 0.874218 ¶ 2054 2056 W4313574702.pdf 2 20 text 0.99852145 "Da’wa h bil ihsan bertopang pada ilmu, sabar dan kelembutan, walaupun terkadang dalam prakteknya tidaklah mudah. Sekali lagi, s ungguh tidak mudah. Namun, kita harus nyakin bahwa sejatinya banyak kebaikan jika sikap ihsan ini dilakukan dalam kehidupan da’wah kita. Salah satunya" 2056 2344 W4313574702.pdf 2 21 separator 0.8722461 ¶ ¶ 2345 2351 W4313574702.pdf 2 22 bibliography 0.8925579 "1 Selain surat -surat di atas juga, disebutkan dalam surat at -Taubah: 100, al -Isra: 23, al -Ahqaf: 15, ar -Rahman: 60, al -Baqarah: 83, an -Nisa: 36, 62, dan al -An’am: 151. Lihat Tarjamah Makna" 2351 2551 W4313574702.pdf 2 23 separator 0.9509051 ¶ 2552 2554 W4313574702.pdf 2 24 paratext 0.42795897 Al_ 2554 2558 W4313574702.pdf 2 25 bibliography 0.33969387 qur 2558 2561 W4313574702.pdf 2 26 paratext 0.43853554 ’an Bahasa Indonesia, Kompleks Percetakan 2561 2602 W4313574702.pdf 2 27 bibliography 0.36607057 al 2602 2606 W4313574702.pdf 2 28 paratext 0.35140026 - 2606 2607 W4313574702.pdf 2 29 bibliography 0.3818246 Qur’an 2607 2613 W4313574702.pdf 2 30 paratext 0.4338105 Raja Fahd, Saudi Arabia. 2613 2638 W4313574702.pdf 2 0 paratext 0.7503337 Wang et al. 0 11 W2536050198.pdf 7 1 title 0.76395446 Firing Frequency of Fast-Spiking Neurons 11 52 W2536050198.pdf 7 2 separator 0.9943217 ¶ 52 54 W2536050198.pdf 7 3 caption 0.9964682 "FIGURE 3 | The correlation between maximal firing frequency and o ther intrinsic properties of human FS neurons. (A) The color coded correlation map of all intrinsic parameters examined in human FS neurons. (B–C)The linear fit of maximal instantaneous frequency vs. AP width (B)and F-I slope (C)of all human FS neurons." 54 376 W2536050198.pdf 7 4 separator 0.9920857 ¶ 376 378 W2536050198.pdf 7 5 text 0.99932265 "cortical FS neurons between species and between cortices. In order to investigate to what extent the firing frequency of FS neurons could reach under physiological activation, we furt her examined the firing of FS neurons in the neocortex of behaving monkey and mouse. In one monkey keeping eye fixation at a target point, we performed single-unit recordings in its posterior parietal cortex ( Figure5A ), which was supposed to be activated during the period of attention captured “bottom-up” by salient stimuli ( Kastner and Ungerleider, 2000; Corbetta and Shulman, 2002 ). Based on their spike waveforms, we identified 18 narrow-spiking units, which were putatively FS neurons (Barthó et al., 2004; Niell and Stryker, 2010 ) and 4 broad- spiking units ( Figures5A,B . see also Materials and Methods), and analyzed all their instantaneous spiking frequencies. W e plotted the cumulative distribution curves of ISIs for indiv idual single units and found the curves of narrow-spiking units are more left-shifted (i.e., higher firing frequency) than thos e of broad-spiking units ( Figure5C ). The maximal instantaneous frequency of those putative FS neurons was 746.0 ±85.8Hz (ranging from 206.7 to 1717.0Hz.), close to that obtained in vitro(611.2±31.3Hz,p=0.16, K-S test. Figure5D )." 378 1699 W2536050198.pdf 7 6 separator 0.9831176 ¶ 1699 1701 W2536050198.pdf 7 7 text 0.99681133 "Considering that FS neurons do not always fire at their highes t frequency during the fixation period, we also examined how often FS neurons fire at high frequencies. With a 1% (or 5%) chance, monkey FS neurons could fire at instantaneous frequencies higher than 542.1 ±85.7Hz (or 363.4 ±59.0Hz. Figures5C,D )." 1701 2018 W2536050198.pdf 7 8 separator 0.97393954 ¶ 2018 2020 W2536050198.pdf 7 9 text 0.99943167 "Next, we investigated the firing frequency of cortical FS neurons of mice by recording single units in mouse V1 inresponse to simple visual stimuli (sinusoidal drifting gratin gs. Figure5E ). During a 2-s stimulation period, narrow-spiking units (putatively FS neurons, Figure5E ) transiently elevated their firing frequency at the onset and fired with higher frequency than broad-spiking units ( Figure5F ). By analyzing all the ISIs during the stimulation period of individual single units, we found that narrow-spiking units discharged with a maximal instantaneous frequency of 561.8 ±13.7Hz (n=18), close to that obtained in vitro(581.7±15.0Hz, p=0.09, K-S test, p=0.56, WRS test. Figure5G )." 2020 2734 W2536050198.pdf 7 10 separator 0.934273 ¶ 2734 2736 W2536050198.pdf 7 11 text 0.99965143 "With a 1% (or 5%) chance, narrow-spiking units discharged with instantaneous frequencies higher than 437.7 ±21.0Hz (or 247.1 ±23.1Hz. Figure5G ). Due to lack of a well- establishedbehaviorparadigmtoactivatetheassociationc ortices of mouse, we could not validate the difference in maximal firing frequency of FS neurons between cortices by in vivo recordings. Together, our results demonstrate that the maxi mal firing frequency of FS neurons in vivois comparable to that foundin vitro, and is able to reach near-kilohertz ultrafast frequencies." 2736 3296 W2536050198.pdf 7 12 separator 0.9950584 ¶ 3296 3298 W2536050198.pdf 7 13 title 0.99202496 DISCUSSION 3298 3309 W2536050198.pdf 7 14 separator 0.99614894 ¶ 3309 3311 W2536050198.pdf 7 15 text 0.99968743 "In this study, we first described and compared the maximal firing frequencies of FS neurons in human, monkey, and mouse neocortex, and also examined its correlation with different neuronal intrinsic properties. And then, the data about maxim al firing frequency obtained in cortical slices of animals were validated by in vivorecordings in behaving monkey and mouse." 3311 3684 W2536050198.pdf 7 16 separator 0.98135173 ¶ 3684 3686 W2536050198.pdf 7 17 paratext 0.98422 Frontiers in Cellular Neuroscience | www.frontiersin.org 8 October 2016 | Volume 10 | Article 239 3686 3784 W2536050198.pdf 7 0 paratext 0.9887746 4Epidemiology and Health 2016;38:e2016002 0 43 W2228320946.pdf 3 1 separator 0.99133486 ¶ 43 45 W2228320946.pdf 3 2 text 0.99887353 "CRC was coded as C18-C20 [9]. Deaths from CRC were ascer - tained from the cause of death listed on death certificates." 45 167 W2228320946.pdf 3 3 separator 0.9954581 ¶ 167 169 W2228320946.pdf 3 4 title 0.98594064 Statistical analysis 169 190 W2228320946.pdf 3 5 separator 0.9937067 ¶ 190 192 W2228320946.pdf 3 6 text 0.99934024 "Person-years were calculated from the baseline enrollment to December 2012 or the date of CRC diagnosis, death, or loss to follow-up. Crude incidence rates (per 100,000 person-years) were calculated from the person-years and number of cases of CRC. Hazard ratios (HRs) were calculated by using the Cox proportional hazard model, after adjusting for age, sex, BMI, smoking status, alcohol consumption, and regular exercise. These analyses were used after the FSG levels were divided into four categories on the basis of cut-offs at 100 mg/dL, 110 mg/dL, and 126 mg/dL. A chi-square goodness-of-fit test was used to assess whether the SNPs were in Hardy-Weinberg equilibrium and to identify differences in genotype frequencies between CRC cases and controls. All statistical tests were two-sided, and statistical significance was determined as p< 0.05. SAS version 9.2 (SAS Institute Inc., Cary, NC, USA) was used for all analyses." 192 1164 W2228320946.pdf 3 7 separator 0.99626917 ¶ 1164 1166 W2228320946.pdf 3 8 title 0.9888425 RESULTS 1166 1174 W2228320946.pdf 3 9 separator 0.9950379 ¶ 1174 1176 W2228320946.pdf 3 10 text 0.9950431 "The basic characteristics of the participants (144,527 in the whole cohort and 1,834 in the subcohort) are summarized in Table 1 and Figure 1. A total of 317 participants were newly di - agnosed with CRC among the 144,527 participants over 771,052 total person-years (mean follow-up 5.3 years) through to De - cember 2012. The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. The population had a low BMI on average, with 39.5% of the men and 15.1% of the women at 25 kg/m2 or above and 3.5% of the men and 1.6% of the women above 30 kg/m2. Both smok - ing and alcohol use were substantially more common in men than in women." 1176 1880 W2228320946.pdf 3 11 separator 0.99356526 ¶ 1881 1883 W2228320946.pdf 3 12 text 0.9822029 "Table 2 shows the age-adjusted rates and relative risks (RRs) of CRC in relation to FSG and the three common SNPs. Higher FSG was associated with an increased risk of CRC, particularly among subjects with impaired fasting glucose (IFG; 100 ≤ FSG ≤ 125 mg/dL). The findings were similar when we examined the relationship of FSG to CRC subgroup among the subjects with DNA data. Considering only those participants with DNA (SNP) data, we examined the potential relationships between genotypes and CRC risk. The RR for CRC for those with geno - type AC or CC in SNP rs3802842 was 1.7 and 1.3 times high - er, respectively, than for those with genotype AA. The RRs for colon cancer and rectal cancer were similar, with the same ge - notypic pattern for SNP rs3802842. Also, those with genotype TT in SNP rs6983267 had an increased risk of rectal cancer (HR, 2.3; 95% CI, 1.3 to 3.9), but not colon cancer. The RR for colon cancer with genotype GG in SNP rs10795668 was signif - icant (HR, 1.9; 95% CI, 0.9 to 3.9)." 1883 2939 W2228320946.pdf 3 13 separator 0.9928584 ¶ 2940 2942 W2228320946.pdf 3 14 text 0.9487063 "Table 3 shows the age-adjusted and gender-adjusted combined effect of SNPs and dysglycemia on the risk of CRC. Among par - ticipants with dysglycemia, both SNPs rs3802842 and rs6983267 were associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3;" 2942 3323 W2228320946.pdf 3 15 separator 0.9951063 ¶ 3324 3326 W2228320946.pdf 3 16 title 0.98189455 Table 2. Risk factors for colorectal cancer incidence as analyzed by Cox proportional hazard models: the Korean Cancer Prevention Study-II 3326 3466 W2228320946.pdf 3 17 separator 0.93394095 ¶ 3466 3468 W2228320946.pdf 3 18 table 0.99481046 "Whole cohort (n= 144,527)Subjects with DNA data (n= 1,691), case-cohort design Colorectal cancer Colon cancer Rectal cancer Case Rate1RR (95% CI) Case RR (95% CI) Case RR (95% CI) Case RR (95% CI) Age (yr) 317 41.1 1.1 (1.1, 1.1) 221 1.1 (1.1, 1.1) 114 1.1 (1.1, 1.2) 107 1.1 (1.1, 1.1) Gender Men Women230 8748.4 29.41.0 (reference) 0.7 (0.5, 0.8)163 581.0 (reference) 0.6 (0.4, 0.8)82 321.0 (reference) 0.6 (0.4, 1.0)81 261.0 (reference) 0.5 (0.3, 0.8) FSG (mg/dL) < 100 100-109 110-125 ≥ 126205 53 22 3732.8 67.9 77.8 93.81.0 (reference) 1.4 (1.0, 1.9) 1.3 (0.9, 2.0) 1.2 (0.9, 1.8)142 37 15 271.0 (reference) 1.1 (0.8, 1.6) 1.8 (1.2, 2.6)73 20 9 121.0 (reference) 1.2 (1.0, 2.8) 1.7 (1.0, 2.8)69 17 6 151.0 (reference) 1.1 (0.7, 1.9) 1.9 (1.1, 3.2) Genetic polymorphism rs3802842 AA 60 1.0 (reference) 33 1.0 (reference) 27 1.0 (reference) AC 124 1.7 (1.2, 2.3) 61 1.5 (1.0, 2.3) 63 2.0 (1.3, 3.1) CC 37 1.3 (0.8, 2.0) 20 1.3 (0.7, 2.4) 17 1.4 (0.8, 2.6) rs6983267 GG 53 1.0 (reference) 25 1.0 (reference) 28 1.0 (reference) GT 102 1.1 (0.8, 1.5) 47 0.8 (0.5, 1.2) 55 1.7 (1.0, 2.7) TT 66 1.4 (1.0, 2.0) 42 0.9 (0.5, 1.5) 24 2.3 (1.3, 3.9) rs10795668 AA 22 1.0 (reference) 9 1.0 (reference) 13 1.0 (reference) AG 99 1.0 (0.6, 1.6) 56 1.4 (0.7, 2.9) 43 0.7 (0.4, 1.3) GG 100 1.4 (0.8, 2.2) 49 1.9 (0.9, 3.9) 51 1.1 (0.6, 1.9) RR, relative risk; CI, confidence interval; FSG, fasting serum glucose." 3469 4984 W2228320946.pdf 3 19 separator 0.5642176 4984 4985 W2228320946.pdf 3 20 table 0.9462528 ¶ 1Age-adjusted rate per 100,000 person years. 4985 5031 W2228320946.pdf 3 0 paratext 0.9905248 Int. J. Mol. Sci. 2022 ,23, 16121 12 of 15 0 42 W4312210472.pdf 11 1 separator 0.99152005 ¶ 42 44 W4312210472.pdf 11 2 text 0.99637604 "for 2 h. After the reaction finished, photocatalyst was separated through centrifugation and the supernatant was examined with UV–Vis spectrophotometer. The result was compared with the unilluminated control group, showing that no OH produced." 44 292 W4312210472.pdf 11 3 separator 0.99650824 ¶ 292 294 W4312210472.pdf 11 4 title 0.9858736 4. Conclusions 294 309 W4312210472.pdf 11 5 separator 0.99677217 ¶ 309 311 W4312210472.pdf 11 6 text 0.998943 "A photocatalyst Zr-MOF-P based on a BINOL-derived phosphoric acid ligand for the selective oxidation of sulfides under white light irradiation was prepared. Comprehen- sive mechanistic studies indicated that Zr-MOF-P had appropriate photo-electrochemical properties for this reaction, and the ESIPT process produced the reactive oxygen radical, which would take an electron from the sulfides. Thus, the sulfides were activated and, sub- sequently, react with ground state oxygen, producing sulfoxides. The unique mechanism without the participation of ROS ensured the high selectivity and substrate compatibility of the reaction. Moreover, as a heterogeneous photocatalyst, Zr-MOF-P had sufficient stability, as it can be easily separated and re-used at least five times without any noticeable change in reactivity. This study demonstrates that phosphoric acids with a large conjugate structure can be used as photocatalysts, and they might have potential applications in more kinds of photocatalytic reactions. Further applications for Zr-MOF-P are under study in our group." 311 1404 W4312210472.pdf 11 7 separator 0.99302983 ¶ 1404 1406 W4312210472.pdf 11 8 text 0.48951662 Supplementary Materials 1406 1430 W4312210472.pdf 11 9 bibliography 0.40374216 : 1430 1431 W4312210472.pdf 11 10 text 0.54467535 The 1431 1435 W4312210472.pdf 11 11 bibliography 0.43427745 1435 1436 W4312210472.pdf 11 12 text 0.47377723 following supporting information can be downloaded at: 1436 1490 W4312210472.pdf 11 13 bibliography 0.441259 https 1490 1496 W4312210472.pdf 11 14 text 0.42238176 :// 1496 1499 W4312210472.pdf 11 15 bibliography 0.56707025 ¶ www 1499 1505 W4312210472.pdf 11 16 text 0.41630125 .m 1505 1507 W4312210472.pdf 11 17 bibliography 0.40964165 dpi 1507 1510 W4312210472.pdf 11 18 text 0.41001233 . 1510 1511 W4312210472.pdf 11 19 bibliography 0.44789335 com/article/10.3390/ijms232416121/s 1511 1546 W4312210472.pdf 11 20 text 0.4202328 1. 1546 1548 W4312210472.pdf 11 21 separator 0.99442655 ¶ 1548 1550 W4312210472.pdf 11 22 bibliography 0.8693702 "Author Contributions: Methodology, Z.Z. (Zhenghua Zhao) and Z.Z. (Zhiguo Zhang); validation, Z.Z. (Zhenghua Zhao), M.L., K.Z. and H.G.; formal analysis, Z.B., Q.Y. and Q.R.; investigation, Z.Z. (Zhenghua Zhao); writing—original draft preparation, Z.Z. (Zhenghua Zhao), Y.S. and Z.Z. (Zhiguo Zhang); writing—review and editing, Z.Z. (Zhenghua Zhao), Y.S. and Z.Z. (Zhiguo Zhang); supervision, Z.Z. (Zhiguo Zhang); All authors have read and agreed to the published version of the manuscript." 1550 2050 W4312210472.pdf 11 23 separator 0.99319184 ¶ 2050 2052 W4312210472.pdf 11 24 text 0.94905996 "Funding: This research was funded by the National Key R&D Program of China (grant number 2021YFC2103704) and National Natural Science Foundation of China (grant number 21878266, 22078288, and U21A20301)." 2052 2260 W4312210472.pdf 11 25 separator 0.9900473 ¶ 2260 2262 W4312210472.pdf 11 26 text 0.5499724 Institutional Review Board Statement: Not applicable. 2262 2316 W4312210472.pdf 11 27 separator 0.98142374 ¶ 2316 2318 W4312210472.pdf 11 28 text 0.40860295 Informed Cons 2318 2332 W4312210472.pdf 11 29 paratext 0.37363824 ent 2332 2335 W4312210472.pdf 11 30 text 0.54825294 Statement: Not applicable. 2335 2362 W4312210472.pdf 11 31 separator 0.98035777 ¶ 2362 2364 W4312210472.pdf 11 32 text 0.9169397 "Data Availability Statement: CCDC 2218003 contains the supplementary crystallographic data of Zr-MOF-P : these data can be obtained free of charge through www.ccdc.cam.ac.uk/data_request/cif (accessed on 26 November 2022), or by emailing data_request" 2364 2619 W4312210472.pdf 11 33 contact 0.6570543 @ 2619 2620 W4312210472.pdf 11 34 text 0.5198306 ccdc 2620 2624 W4312210472.pdf 11 35 contact 0.47034338 . 2624 2625 W4312210472.pdf 11 36 text 0.47799486 cam 2625 2628 W4312210472.pdf 11 37 contact 0.8795344 ".ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44-1223-336033." 2628 2760 W4312210472.pdf 11 38 separator 0.9930953 ¶ 2760 2762 W4312210472.pdf 11 39 text 0.59755105 Acknowledgments: We gratefully acknowledge Jianyang Pan (Research and Service 2762 2840 W4312210472.pdf 11 40 contact 0.4552158 Center 2840 2847 W4312210472.pdf 11 41 text 0.63849705 ", College of Pharmaceutical Sciences, Zhejiang University) for NMR characterization." 2847 2933 W4312210472.pdf 11 42 separator 0.9844858 ¶ 2933 2935 W4312210472.pdf 11 43 text 0.7184763 Conflicts of Interest: The authors declare no conflict of interest. 2935 3001 W4312210472.pdf 11 44 separator 0.99502945 ¶ 3001 3003 W4312210472.pdf 11 45 title 0.73889124 References 3003 3014 W4312210472.pdf 11 46 separator 0.9887768 ¶ 3014 3016 W4312210472.pdf 11 47 bibliography 0.99749744 "1. Wang, S.S.; Yang, G.Y. Recent Advances in Polyoxometalate-Catalyzed Reactions. Chem. Rev. 2015 ,115, 4893–4962. [CrossRef] [PubMed]" 3016 3153 W4312210472.pdf 11 48 separator 0.9381782 ¶ 3153 3155 W4312210472.pdf 11 49 bibliography 0.9980192 "2. Mansir, N.; Taufiq-Yap, Y.H.; Rashid, U.; Lokman, I.M. Investigation of heterogeneous solid acid catalyst performance on low grade feedstocks for biodiesel production: A review. Energy Convers. Manag. 2017 ,141, 171–182. [CrossRef]" 3155 3391 W4312210472.pdf 11 50 separator 0.96370256 ¶ 3391 3393 W4312210472.pdf 11 51 bibliography 0.9974093 "3. Doustkhah, E.; Lin, J.; Rostamnia, S.; Len, C.; Luque, R.; Luo, X.; Bando, Y.; Wu, K.C.; Kim, J.; Yamauchi, Y.; et al. Development of Sulfonic-Acid-Functionalized Mesoporous Materials: Synthesis and Catalytic Applications. Chem. Eur. J. 2019 ,25, 1614–1635. [CrossRef] [PubMed]" 3393 3678 W4312210472.pdf 11 52 separator 0.9736434 ¶ 3678 3680 W4312210472.pdf 11 53 bibliography 0.9974997 4. Buru, C.T.; Farha, O.K. Strategies for Incorporating Catalytically Active Polyoxometalates in Metal 3680 3783 W4312210472.pdf 11 0 paratext 0.9759832 "RBRH , Porto Alegre, v. 26, e16, 2021Assis et al. 9/13" 0 56 W3177186807.pdf 8 1 text 0.9964963 "by the negative charges of the mineral and organic colloids of the soil when situated at pH 7.0 ± 2.0. According to the authors, in situations with soil at pH 6.0 the Imazapic will be quite dissociated and the adsorption mechanism should be exclusively ionic in order to occur a significant adsorption." 56 372 W3177186807.pdf 8 2 separator 0.9785482 ¶ 372 374 W3177186807.pdf 8 3 text 0.9993425 "The calculated values of Kd had variations of 0.052 to 0.083 and 0.19 to 0.25 L kg-1 in YUd and RYOd, respectively, as shown in Table 6 . The mass transfer coefficient (α) increased with the increase of the degree of chemical non-equilibrium in the sorption (1- f). According to Gaber et al. (1995) , high values of α indicate the presence of slow sorption kinetics. The mass transfer coefficient (α) was higher for the RYOd, where there was an increase in the chemical non-equilibrium conditions of the sorption. The parameter f corresponds to sorption sites in equilibrium and indicates the degree of chemical non-equilibrium in the sorption." 374 1057 W3177186807.pdf 8 4 separator 0.9845557 ¶ 1057 1059 W3177186807.pdf 8 5 text 0.9996557 "The breakthrough curves, experimental and fitted with the CDE – 2 sorption sites are presented in Figure 5, YUd (A) and RYOd (B). The level of interaction between the Imazapic molecule and the soil is evaluated according to the value of the retardation factor, the higher the value of the retardation factor the greater the interaction. The asymmetric shape of the breakthrough curves, due to the prolongation of the descending part of the curves, can be attributed to the kinetic desorption process, and the ascending part of the curves, adsorption phase, refers to the linear isotherm processes. Asymmetric behavior was more evident in RYOd than in YUd.The initial part of the breakthrough curve is mainly due to interaction with soil organic matter, which is weak and reversible, and where equilibrium is rapidly established. The descending phase of the curve corresponds to the very slow desorption due to the interactions with the iron oxide, whose binding is stronger, and the equilibrium is established more slowly, as observed for RYOd, which had a great interaction with Imazapic." 1059 2206 W3177186807.pdf 8 6 separator 0.9909829 ¶ 2206 2208 W3177186807.pdf 8 7 text 0.9752465 Imazapic has higher interaction with organic matter (OM). 2208 2268 W3177186807.pdf 8 8 separator 0.55437946 ¶ 2268 2269 W3177186807.pdf 8 9 text 0.9996571 "However, the values of Total Carbon (OC) are the same for the 0-20 cm layers for both soils ( Table 2 ). The organic matter in the two soils favors the hydrophobic interactions more than the electrostatic interactions between the soil colloids ( Spark & Swift, 2002). Thus, the main physical and chemical attributes of the soil evaluated in the Imazapic adsorption process were iron (Fed and Feo) oxides and clay content, higher in RYOd." 2269 2727 W3177186807.pdf 8 10 separator 0.99658597 ¶ 2727 2729 W3177186807.pdf 8 11 title 0.9878045 Kd, Koc coefficients and GUS index 2729 2764 W3177186807.pdf 8 12 separator 0.9926589 ¶ 2764 2766 W3177186807.pdf 8 13 text 0.9996476 "As observed in Table 6 , the calculated Koc values for YUd ranged from 5.2 to 5.3 (L kg-1), whereas for RYOd the variation was 12.3 to 15.7 (L kg-1). This difference in Koc values is associated to the high content of clay and iron oxides in the RYOd, the main factors that influenced the Imazapic adsorption difference between the soils, since the OC content and the mineralogical characteristics were identical for the two studied soils." 2766 3224 W3177186807.pdf 8 14 separator 0.6769318 ¶ 3224 3226 W3177186807.pdf 8 15 text 0.9906953 "Some parameters are used as potential indicators of leaching of pesticide molecules such as Kd, Koc and GUS index. The GUS" 3226 3355 W3177186807.pdf 8 16 caption 0.99623924 "Figure 5. Breakthrough curves (experimental and fitted) from Imazapic to: (A) dystrophic Yellow Ultisol (YUd); and (B) dystrophic Red-Yellow Oxisol (RYOd)." 3356 3516 W3177186807.pdf 8 17 separator 0.9795398 ¶ 3516 3518 W3177186807.pdf 8 18 caption 0.6353654 "Table 6. Hydrodispersive parameters calculated from the parameters obtained by fitting the CDE-2 sorption sites model to the data from the Imazapic miscible displacement tests for the dystrophic Red-Yellow Oxisol and the" 3518 3743 W3177186807.pdf 8 19 table 0.43266127 dystrophic Yellow Ultisol. 3743 3770 W3177186807.pdf 8 20 separator 0.7984079 ¶ 3770 3772 W3177186807.pdf 8 21 table 0.9919605 "0-20 α Kdf (1-f) cm h-1L kg-1-- -- dystrophic Yellow Ultisol R1 6.18E-3 0.083 0.027 0.973 R2 1.05E-3 0.052 0.991 0.009 dystrophic Red-Yellow Oxisol R1 7.75E-3 0.197 0.203 0.797 R2 1.24E-2 0.252 0.001 0.999" 3772 3992 W3177186807.pdf 8 0 paratext 0.8447667 COMPETÊNCIAS E APRENDIZAGEM EMPREENDEDORA NO CONTEXTO DE INSUCESSO EMPRESARIAL199 0 81 W2231444670.pdf 27 1 separator 0.9774816 ¶ 81 83 W2231444670.pdf 27 2 paratext 0.47250608 Desenvolvimento 83 99 W2231444670.pdf 27 3 bibliography 0.65765965 em QuestãoGLOBAL ENTREPRENEURSHIP MONITOR 2012: Global Report. 99 162 W2231444670.pdf 27 4 paratext 0.49356407 GEM 162 166 W2231444670.pdf 27 5 bibliography 0.6038897 . 166 167 W2231444670.pdf 27 6 separator 0.81743985 ¶ 169 171 W2231444670.pdf 27 7 bibliography 0.985977 Disponível em: . Acesso em: 25 fev. 2013. 171 243 W2231444670.pdf 27 8 separator 0.985605 ¶ 243 245 W2231444670.pdf 27 9 bibliography 0.9978827 "HEINZE, I. Entrepreneur sense-making of business failure. Small Enterprise Rese- arch, v. 20, n. 1, p. 21-39, 2013." 245 363 W2231444670.pdf 27 10 separator 0.9709154 ¶ 363 365 W2231444670.pdf 27 11 bibliography 0.99776727 "HIGGINS, D.; ASPINALL, C. Learning to learn: a case for developing small firm owner/managers. Journal of Small Business and Enterprise Development, v. 18, n. 1, p. 43-57, 2011." 365 548 W2231444670.pdf 27 12 separator 0.98072946 ¶ 548 550 W2231444670.pdf 27 13 bibliography 0.99083257 "HISRICH, R. D.; PETERS, M. P .; SHEPHERD, D. A. Empreendedorismo. 9. ed. Porto Alegre: AMGH, 2014." 550 652 W2231444670.pdf 27 14 separator 0.9645617 ¶ 652 654 W2231444670.pdf 27 15 bibliography 0.9940459 "INSTITUTO BRASILEIRO DE GEOGRAFIA E ESTATÍSTICA. IBGE. De- mografia das empresas 2010. Estudos e Pesquisas. Informações econômicas. Rio de Janeiro. Disponível em: . Acesso em: 3 mar. 2014." 654 939 W2231444670.pdf 27 16 separator 0.9861156 ¶ 939 941 W2231444670.pdf 27 17 bibliography 0.9979937 "JENKINS, A. S.; WIKLUND, J.; BRUNDIN, E. Individual responses to firm failure: appraisals, grief, and the influence of prior failure experience. Journal of Business Venturing, v. 29, n. 1, p. 17-33, 2014." 941 1152 W2231444670.pdf 27 18 separator 0.9753382 ¶ 1152 1154 W2231444670.pdf 27 19 bibliography 0.9979575 "KOLB, D. A. Experiential Learning: experience as the source of learning and deve- lopment. Englewood Cliffs, New Jersey: Prentice Hall, 1984." 1154 1298 W2231444670.pdf 27 20 separator 0.97187835 ¶ 1299 1301 W2231444670.pdf 27 21 bibliography 0.9980611 "LÉVESQUE, M.; MINNITI, M.; SHEPHERD, D. Entrepreneur’s decisions on timing of entry: Learning from participation and from the experiences of others. Entrepreneurship Theory and Practice, v. 33, n. 2, p. 547-570, mar. 2009." 1301 1527 W2231444670.pdf 27 22 separator 0.9727361 ¶ 1527 1529 W2231444670.pdf 27 23 bibliography 0.9979777 "LIMA, E. Estratégias de pequenas e médias empresas: uma revisão. Rege, São Paulo, v. 17, n. 2, p. 169-187, abr./jun. 2010." 1529 1655 W2231444670.pdf 27 24 separator 0.980301 ¶ 1655 1657 W2231444670.pdf 27 25 bibliography 0.99791604 "MAN, T . W. Y.; LAU, T .; SNAPE, E. Entrepreneurial competencies and the per - formance of small and medium enterprises: an investigation through a framework of competitiveness. Journal of Small Business and Entrepreneurship, v. 21, n. 3, p. 690-708, 2008." 1657 1922 W2231444670.pdf 27 26 separator 0.9645443 ¶ 1922 1924 W2231444670.pdf 27 27 bibliography 0.99803406 "MAN, T . W. Y. Exploring the behavioral patterns of entrepreneurial learning: a competency approach. Education & Training, v. 48, n. 5, p. 309-321, 2006." 1924 2081 W2231444670.pdf 27 28 separator 0.96654093 ¶ 2082 2084 W2231444670.pdf 27 29 bibliography 0.9969569 "______. LAU, T . The context of entrepreneurship in Hong-Kong: an investigation through the patterns of entrepreneurial competencies in contrasting industrial environments. Journal of Small Business and Enterprise Development. v. 12, n. 4, p. 464-481, 2005." 2084 2351 W2231444670.pdf 27 0 paratext 0.933162 "Int. J. Mol. Sci. 2010 , 11 ¶ 1299" 0 53 W2063165809.pdf 30 1 separator 0.98793405 ¶ 53 55 W2063165809.pdf 30 2 text 0.99873 "in modeling aromaticity when considered within se mi-empirical computational framework, while the electronegativity responds better in conjunction with ab initio methods." 55 230 W2063165809.pdf 30 3 separator 0.84939766 ¶ 232 234 W2063165809.pdf 30 4 text 0.99952054 "From quantum computational perspective, the cons ecrated HF method seems to get more marks in fulfillment of above Aroma1-to-5 rules, cumulated for electronegativity and chemical hardness based- aromaticity scales; it leads with the important idea the correlation effects are not determinant in aromaticity phenomenology, an idea confirmed also by the fact the dens ity functional without exchange and correlation produces not-negligible fits with Aroma1, 2, and 4 rules in electronegativity framework." 234 749 W2063165809.pdf 30 5 separator 0.98798287 ¶ 751 753 W2063165809.pdf 30 6 text 0.99843 "Overall, few basic ideas in computing aromaticity should be finally emphasized (i) there is preferable computing aromaticity in an absolute manner , i.e., for each molecule based on its pre- and post- bonding properties (as is th e present compactness definition, for instance) without involving other referential molecule, as is often case in the fashioned aromaticity scales; (ii) the comparison between various aromaticity absolut e scales is to be done respecting that one based on a structural or reactivity index with attested observational character (as is the present polarizability based- aromaticity); (iii) the rules derived from the absolute aroma ticity scale based on observable quantum index should be considered for further guidance for the rest of aromaticity scales considered; (iv) the aromaticity concept , although currently associated with stability character of molecules , seems to not depending on correlation and sometimes neither by exchange effects ." 753 1774 W2063165809.pdf 30 7 separator 0.796304 ¶ 1776 1778 W2063165809.pdf 30 8 text 0.99948686 "Future quests should enlarge the basis of the present conclusions by performing comparative aromaticity studies at the level of biomolecules and nanostructures; at the end of the day, the aromaticity concept in general and with its particular specialization should represent just a tool/vehicle in modeling and understanding the chemical bond of atoms in molecules and nanostructures, either in isolated or interacting states." 1778 2212 W2063165809.pdf 30 9 separator 0.9971176 ¶ 2214 2216 W2063165809.pdf 30 10 title 0.98687774 Acknowledgements 2216 2233 W2063165809.pdf 30 11 separator 0.99574745 ¶ 2234 2236 W2063165809.pdf 30 12 text 0.99890316 "Useful discussions on historical aspects of aromaticity concept and on the present studied molecules with Dr. Delia Isac, Associate Professor for Didactic Chemistry at West University of Timisoara, now retired, are kindly thanked. As well, th e editors and the associate team of International Journal of Molecular Sciences are very much thanked for supporting the open access publishing of highly rated scientific works in general, and of this paper in special. Author is grateful also to Brietta Pike of MDPI for final English editing of the manuscript." 2236 2808 W2063165809.pdf 30 13 separator 0.99672604 ¶ 2810 2812 W2063165809.pdf 30 14 title 0.86141837 References 2812 2823 W2063165809.pdf 30 15 separator 0.99211085 ¶ 2824 2826 W2063165809.pdf 30 16 bibliography 0.99748397 "1. Kekulé, A.F. Untersuchungen uber aromatische Verbindungen. Liebigs Ann. Chem. 1866 , 137, 129–136." 2826 2931 W2063165809.pdf 30 17 separator 0.67086816 ¶ 2932 2934 W2063165809.pdf 30 18 bibliography 0.99745995 "2. Thomson, J.J. On the structure of the molecule and chemical combination. Philos. Mag. 1921 , 41, 510–538." 2934 3047 W2063165809.pdf 30 19 separator 0.7927067 ¶ 3048 3050 W2063165809.pdf 30 20 bibliography 0.9976949 3. Hückel, E. Quantentheoretische Beiträge zum Benzolproblem. Z. Physik 1931 , 70, 204–286. 3050 3143 W2063165809.pdf 30 0 paratext 0.9875349 Page 13/17of 0 12 W4252640052.pdf 12 1 title 0.7675518 pN staging. c The percentage of 12 44 W4252640052.pdf 12 2 text 0.42572653 pM 44 47 W4252640052.pdf 12 3 title 0.5784847 staging. 47 56 W4252640052.pdf 12 4 text 0.3120235 d 56 58 W4252640052.pdf 12 5 title 0.3729184 The 58 63 W4252640052.pdf 12 6 text 0.32664362 percentage 63 73 W4252640052.pdf 12 7 title 0.3795098 of 73 76 W4252640052.pdf 12 8 text 0.43810734 pTNM 76 81 W4252640052.pdf 12 9 title 0.41210875 staging. 81 90 W4252640052.pdf 12 10 caption 0.5007081 e. The stacked 90 106 W4252640052.pdf 12 11 separator 0.38939705 ¶ 106 107 W4252640052.pdf 12 12 caption 0.68708974 diagram shows the percentage of pathological grading at different NEK7 expression level. f. The box plot 107 212 W4252640052.pdf 12 13 text 0.4624366 212 213 W4252640052.pdf 12 14 separator 0.4327546 ¶ 213 214 W4252640052.pdf 12 15 caption 0.66275406 shows 214 220 W4252640052.pdf 12 16 text 0.5086196 NEK7 220 225 W4252640052.pdf 12 17 caption 0.5659397 expression level in 225 245 W4252640052.pdf 12 18 text 0.50184286 245 246 W4252640052.pdf 12 19 caption 0.5193479 samples 246 253 W4252640052.pdf 12 20 text 0.5530344 of different p 253 268 W4252640052.pdf 12 21 caption 0.51972425 T stage staging. 268 284 W4252640052.pdf 12 22 separator 0.9935141 ¶ 284 286 W4252640052.pdf 12 23 caption 0.8272504 Figure 3 286 295 W4252640052.pdf 12 24 separator 0.97481036 ¶ 295 297 W4252640052.pdf 12 25 caption 0.9735485 a. The spot plot shows that Tregs in 297 334 W4252640052.pdf 12 0 title 0.9890196 3.4 PPI analysis of DKD-associated HCC 0 38 W4391108911.pdf 4 1 separator 0.5937891 38 39 W4391108911.pdf 4 2 title 0.8846992 ¶ causative genes 39 56 W4391108911.pdf 4 3 separator 0.98707455 ¶ 56 58 W4391108911.pdf 4 4 text 0.99887717 "We constructed a PPI network using the STRING database to recognize the possible causativ e genes of DKD-related HCC from 101 up-secreted and 104 HCC-related DEGs. The Cytoscapesoftware identi fied three important protein interaction modules with a leading eigenvector algorithm. These three modules contained 132 genes, 67 from DKD and 68 from HCC (Supplementary Table S8 ). Eight genes, COL15A1, ECM1, CTHRC1, C7, LUM, MS4A6A, PLVAP, and LYVE1 belong to DKD and HCC ( Figure 4A ). Their relationships with DKD and" 58 587 W4391108911.pdf 4 5 separator 0.8655406 ¶ 587 589 W4391108911.pdf 4 6 table 0.71588224 "B C D EF GA" 589 607 W4391108911.pdf 4 7 separator 0.975209 ¶ 607 609 W4391108911.pdf 4 8 caption 0.65645915 FIGURE 2 609 618 W4391108911.pdf 4 9 separator 0.99324846 ¶ 618 620 W4391108911.pdf 4 10 text 0.9795445 "Identify essential module genes for HCC. (A)Determines the optimal bvalue using a scale-free topological model and selects b= 5 as the soft threshold based on average connectivity and scale independence. (B)Displays a hierarchical clustering dendrogram of the module identi fiers." 620 902 W4391108911.pdf 4 11 separator 0.59706897 ¶ 902 904 W4391108911.pdf 4 12 text 0.9976566 "The dendrogram of genes was obtained by average chained hierarchical clustering —color rows below the dendrogram show module assignments determined by dynamic tree cuts. (C)Visually characterizes the correlation of the eigengenes. The branches (meta-modules) of the dendrogram combine sets of eigengenes that are positively correlated. The heatmap shows the neighbors in the Eigengenes network. Each row and column in the heatmap represent modular eigengenes (indicated by color). Blue indicates low adjacency with a negative correlation, and red indicates highadjacency with a positive correlation. (D)Displays a graph of the relationship between the module genes and the HCC. Each row corresponds to a module eigengenes and the column to a trait. Each cell was filled with the corresponding correlation and p-value. A redder color indicates a strong positive correlation between the phenotypic trait and the module eigengene, while a greener color indicates a strong negative correlation." 904 1904 W4391108911.pdf 4 13 separator 0.95625955 ¶ 1904 1906 W4391108911.pdf 4 14 text 0.993749 "(E)indicates the correlation between turquoise module members and the gene signi ficance for HCC. Gene signi ficance and module membership have a very signi ficant correlation (0.86), implying that hub genes of the turquoise module also tend to be highly correlated with HCC. (F)indicates the correlation between the pink module members and the gene signi ficance for HCC. Gene signi ficance and module membership have a very significant correlation (0.76), implying that the hub genes of the pink module also tend to be highly correlated with HCC. (G)shows the intersection of crucial module genes with DEGs. The genes with R>0.5 from Module-trait relationships and kME_MM>0.8 in WGCNA analysis were consideredhub genes in modules highly associated with HCC ( Supplementary Table S3 ).Chen et al. 10.3389/fimmu.2024.1339373" 1906 2733 W4391108911.pdf 4 15 separator 0.99159783 ¶ 2733 2735 W4391108911.pdf 4 16 paratext 0.9390463 Frontiers in Immunology frontiersin.org 05 2735 2778 W4391108911.pdf 4 0 paratext 0.85260785 "Review of: ""The" 0 15 W4385416854.pdf 0 1 title 0.5822006 pros and cons of utilizing crude herbal 15 55 W4385416854.pdf 0 2 paratext 0.46922094 ¶ 55 57 W4385416854.pdf 0 3 title 0.640765 preparations as opposed to purified active ingredients 57 112 W4385416854.pdf 0 4 paratext 0.7503268 ", with emphasis on the COVID pandemic""" 112 152 W4385416854.pdf 0 5 separator 0.9533522 ¶ 152 154 W4385416854.pdf 0 6 contact 0.6091938 Ghulam Murtaza ¶ 154 171 W4385416854.pdf 0 7 paratext 0.5231206 1 171 173 W4385416854.pdf 0 8 contact 0.6985376 "¶ 1 Kunming University of Science and Technology" 173 225 W4385416854.pdf 0 9 separator 0.9745046 ¶ 225 227 W4385416854.pdf 0 10 title 0.5993458 P 227 229 W4385416854.pdf 0 11 text 0.4986486 otential 229 237 W4385416854.pdf 0 12 title 0.53021014 competing interests 237 257 W4385416854.pdf 0 13 text 0.7537078 : 257 258 W4385416854.pdf 0 14 separator 0.7466639 ¶ 258 260 W4385416854.pdf 0 15 text 0.9903959 No potential competing interests to declare. 261 306 W4385416854.pdf 0 16 separator 0.61223054 ¶ 306 308 W4385416854.pdf 0 17 text 0.99729973 "I noticed that authors should improve the conclusion and future suggestion.The paper places a focus on a few case studies should add more case studies. The author should improve the readability of the paper, dividing the analysis into several subsections." 309 569 W4385416854.pdf 0 18 separator 0.57911485 ¶ 571 573 W4385416854.pdf 0 19 text 0.99400926 "In the working method, it should be specified which of the types of research is review, narrative, cross-sectional or qualitative" 573 705 W4385416854.pdf 0 20 separator 0.9628658 ¶ 705 707 W4385416854.pdf 0 21 paratext 0.9467426 "Qeios, CC-BY 4.0 · Review, July 31, 2023 Qeios ID: O8JLP0 · https://doi.org/10.32388/O8JLP0 1 /" 707 820 W4385416854.pdf 0 22 separator 0.77639747 ¶ 1 820 824 W4385416854.pdf 0 0 text 0.997753 "cis-SNPs. It is interesting to note that, among these 18 genes, the first five (CYP3A5, CYP2D6, CYP4F12, CYP2E1 and CYP2U1) having more than 40 cis-SNPs. In all cases FDR based analysis results in identifying more cis-SNPs for these 18 genes compared to that of Yang et al. (2010) [33]." 0 294 W1965273462.pdf 6 1 separator 0.9969262 ¶ 294 296 W1965273462.pdf 6 2 title 0.98614115 Discussion 296 307 W1965273462.pdf 6 3 separator 0.99610126 ¶ 307 309 W1965273462.pdf 6 4 text 0.99863553 "In contrast to previously available methods based on p- values, the empirical Bayes method uses local false dis- covery rate (lfdr) as the threshold. This method controls false positive rate. For a particular SNP, the lfdr is com- puted for the site-specific evidence whereas the FDR averages over other sites with stronger evidence. There are some limitations of using FDR which may result in" 309 715 W1965273462.pdf 6 5 separator 0.8126153 ¶ 715 717 W1965273462.pdf 6 6 caption 0.9826948 Figure 3 QQ-plot for eight SNPs . 717 751 W1965273462.pdf 6 7 separator 0.9963075 ¶ 751 753 W1965273462.pdf 6 8 title 0.97577864 Table 1 The True FDR Performance of Controlled FDR in EB Models 753 817 W1965273462.pdf 6 9 separator 0.821427 ¶ 817 819 W1965273462.pdf 6 10 table 0.99221385 "True fraction of DE Controlled FDR Nonparametric empirical Bayes Parametric empirical Bayes 0.01 0.05 0.10 0.01 0.05 0.10 0.01 0.004 0.029 0.067 0.005 0.042 0.090 0.05 0.006 0.041 0.079 0.006 0.045 0.094 0.10 0.007 0.043 0.087 0.008 0.047 0.097" 819 1074 W1965273462.pdf 6 11 separator 0.982517 ¶ 1074 1076 W1965273462.pdf 6 12 caption 0.98083127 "Figure 4 Minor allele frequency (MAF) distribution .Xa x i s corresponds to minor allele frequency 25% to 50%.Chakraborty et al.BMC Genomics 2013, 14(Suppl 8):S8" 1076 1240 W1965273462.pdf 6 13 separator 0.90006614 ¶ 1240 1242 W1965273462.pdf 6 14 paratext 0.9554674 http://www.biomedcentral.com/1471-2164/14/S8/S8Page 7 of 9 1242 1301 W1965273462.pdf 6 0 paratext 0.9877838 International Seminars in Surgical Oncology 2006, 3:29 http://www.issoonline.com/content/3/1/29 0 96 W2147530962.pdf 7 1 separator 0.5923557 ¶ 96 98 W2147530962.pdf 7 2 paratext 0.9899697 Page 8 of 11 98 111 W2147530962.pdf 7 3 separator 0.9906459 ¶ 111 113 W2147530962.pdf 7 4 text 0.99459153 "(page number not for citation purposes)The same occurred for the estrogen receptor, 59.5% before and 25.9% after drug use, and progesterone receptor, 59.34% and 29.6%, respectively. Both showed a signifi- cant reduction. Biomarker results suggest that lower tamoxifen doses produce results similar to those of the standard dose. If applied to clinical trials, such findings may lead to a significant reduction in costs and less side effects.Our results are similar to those of Uehara [42], who also evaluated estrogen and progesterone receptor positivity in breast cancer of women treated with tamoxifen. However, tamoxifen was used at a 20 mg/day dose for 14 days. The mentioned author observed a ratio reduction from 55.4% to 10.2% in cells stained for estrogen receptors, and from 59.2% to 18.9% in those stained for progesterone recep- tors. In a similar manner, using a 10 mg/day dose of the drug for 14 days, our data revealed a reduction from 59.5% to 25.9% and from 59.3% to 29.6% for estrogen and progesterone receptors, respectively." 113 1191 W2147530962.pdf 7 5 separator 0.97472864 ¶ 1191 1193 W2147530962.pdf 7 6 text 0.99958944 "Likewise, results obtained by Decensi et al. [2] demon- strated that use of 1, 5 or 20 mg/day dose of tamoxifen for four weeks, lead to a similar reduction in proliferative activity of breast carcinoma, evaluated by Ki-67 mono- clonal antibody. In the group using a tamoxifen dose of 1 mg/day, 4-hydroxytamoxifen metabolite level was 10–20 times higher than the minimum inhibitory concentration." 1193 1601 W2147530962.pdf 7 7 separator 0.94421047 ¶ 1601 1603 W2147530962.pdf 7 8 text 0.9993753 "In the current study, the percentage of nuclei stained by Ki-67 monoclonal antibody after using 10 mg/day of tamoxifen for 14 days decreased from 24.7% to 10.4%." 1603 1769 W2147530962.pdf 7 9 separator 0.8671681 ¶ 1769 1771 W2147530962.pdf 7 10 text 0.9993522 "Consistent with this result, Descensi et al. [2] obtained a 21.2% to 14.0% decrease in nuclei staining, demonstrat- ing that our results are similar to those obtained by the above-mentioned authors." 1771 1976 W2147530962.pdf 7 11 separator 0.94888175 ¶ 1976 1978 W2147530962.pdf 7 12 text 0.9994435 "Our results showed that using 10 mg/day of tamoxifen for 14 days is enough to reduce proliferative activity. Descensi et al. [2] described that this activity was similarly reduced" 1978 2162 W2147530962.pdf 7 13 separator 0.99549186 ¶ 2162 2164 W2147530962.pdf 7 14 title 0.598237 Table 5: Percentage of nuclei stained by estrogen receptor (1D5) in Group B (tamoxifen 10 mg) before and after 2164 2275 W2147530962.pdf 7 15 table 0.47589564 14 2275 2278 W2147530962.pdf 7 16 title 0.51652324 days of 2278 2286 W2147530962.pdf 7 17 table 0.62347996 "drug use (magnified 400×)." 2286 2316 W2147530962.pdf 7 18 separator 0.6410324 ¶ 2316 2318 W2147530962.pdf 7 19 table 0.99162054 "PATIENT Before tamoxifen 10 mg (% stained cells) 1 4 days after tamoxifen 10 mg (% stained cells) 1 68.59 30.25 2 45.68 12.47 3 69.48 26.56 4 55.26 12.56 5 0.00 0.00 6 68.67 26.11 7 71.39 10.58 8 74.37 55.42 9 94.96 27.85 10 70.87 20.32 11 100.00 81.32 12 25.63 13.58 13 10.25 2.25 14 92.54 32.38 15 21.21 4.29 16 100.00 50.26 17 14.15 5.58 18 88.59 56.21 MEAN 59.53 25.99Box" 2318 2733 W2147530962.pdf 7 20 caption 0.9123647 -plots for mean Ki-67 va riables (MIB-1) in Group B (tamoxifen 10 mg) before and 14 days of treatmentFigure 4 2733 2842 W2147530962.pdf 7 21 separator 0.80969346 ¶ 2842 2844 W2147530962.pdf 7 22 caption 0.96578336 "Box-plots for mean Ki-67 va riables (MIB-1) in Group B (tamoxifen 10 mg) before and 14 days of treatment.After " 2844 2959 W2147530962.pdf 7 23 table 0.76812387 Before 2959 2965 W2147530962.pdf 7 24 caption 0.53136045 % 2965 2966 W2147530962.pdf 7 25 table 0.8887925 "positivo60 50 40 30 20 10 0 Wilcoxon (Group B" 2966 3028 W2147530962.pdf 7 26 caption 0.48593992 : 3028 3029 W2147530962.pdf 7 27 table 0.624069 "Before x After) Z = 3.724 p<0.001* Standard Deviation: Before = 15.94 After = 9.26" 3029 3121 W2147530962.pdf 7 0 separator 0.9028924 ¶ 1 2 W2995142178.pdf 47 1 paratext 0.7769459 48 2 5 W2995142178.pdf 47 2 separator 0.98727655 ¶ 6 8 W2995142178.pdf 47 3 caption 0.9710788 "Supplementary Fig. 4: Glucose tolerance, islet-cell pr oliferation, and islet-cell 1 apoptosis during macrophage depletion and adoptive transfer in the absence or 2 presence of STZ." 9 199 W2995142178.pdf 47 4 table 0.5132131 3 200 202 W2995142178.pdf 47 5 separator 0.6880602 ¶ 203 205 W2995142178.pdf 47 6 table 0.55479693 "(A) Intraperitoneal glucose tolerance test (IPGTT, 1 g glucose/kg body weight) 13 days 4 following the first dose of STZ/acetate buffer ; n=5 mice/ control, control + PBS -lip, STZ 5 + PBS -lip, STZ + CLOD -lip groups; n=4 mice/ STZ group" 205 450 W2995142178.pdf 47 7 text 0.35236347 , 450 451 W2995142178.pdf 47 8 table 0.38193956 and n=3 mice 451 464 W2995142178.pdf 47 9 text 0.34612226 / 464 465 W2995142178.pdf 47 10 table 0.38225132 control 465 472 W2995142178.pdf 47 11 text 0.35038364 + 472 474 W2995142178.pdf 47 12 table 0.44618404 "6 CLOD -lip group. 7 ¶" 474 502 W2995142178.pdf 47 13 caption 0.5699403 (B) Incremental area under the curve (AUC) for mice in ( A); 502 564 W2995142178.pdf 47 14 table 0.553506 n=5 564 567 W2995142178.pdf 47 15 caption 0.45587185 567 568 W2995142178.pdf 47 16 table 0.5017021 mice/control 568 580 W2995142178.pdf 47 17 caption 0.51687866 , 580 581 W2995142178.pdf 47 18 table 0.45327577 control 581 589 W2995142178.pdf 47 19 caption 0.46382675 + 589 591 W2995142178.pdf 47 20 table 0.47919637 "8 PBS-lip, STZ + PBS -lip, STZ + CLOD -lip groups; n= 4 mice/STZ group, and n=3 9 mice/control + CLOD -lip group" 591 710 W2995142178.pdf 47 21 caption 0.32999521 , 710 711 W2995142178.pdf 47 22 table 0.3383165 *p < 0.05 STZ versus control 711 740 W2995142178.pdf 47 23 caption 0.370958 , 740 741 W2995142178.pdf 47 24 table 0.33801982 one 741 745 W2995142178.pdf 47 25 caption 0.3489655 -way A 745 752 W2995142178.pdf 47 26 table 0.37407953 "NOVA with 10 Tukey’ s multiple comparisons test" 752 802 W2995142178.pdf 47 27 caption 0.2813311 . 802 803 W2995142178.pdf 47 28 table 0.3214155 11 804 807 W2995142178.pdf 47 29 separator 0.93808305 ¶ 808 810 W2995142178.pdf 47 30 title 0.9070656 (C) Quantification of TUNEL+ islet cells and ( D) pHH3+ islet cells harvested from control 810 901 W2995142178.pdf 47 31 separator 0.835437 12 ¶ 901 907 W2995142178.pdf 47 32 text 0.9046823 "or mu ltiple low -dose STZ treated mice 2 weeks from the start of treatment. Between 13 394-16144 nuclei per section were counted; n=3 -5, One -way ANOVA with Tukey’s 14 multiple comparisons test." 907 1112 W2995142178.pdf 47 33 separator 0.79900044 15 ¶ 1113 1119 W2995142178.pdf 47 34 title 0.9204961 (E) Quantification of TUNEL+ islet cells and ( F) EdU+ islet cells in pancr eatic sections 1119 1210 W2995142178.pdf 47 35 separator 0.9458041 16 ¶ 1210 1216 W2995142178.pdf 47 36 text 0.93783295 "from control or multiple low -dose STZ (50 mg/kg) treated mice 28 days from the start of 17 the STZ/control treatmen t. EdU (1 mg) was injected daily i.p. for the last five days 18 before the sacrifice. Between 370-2615 islet cells per section were counted; n=3 -5, 19 One-way ANOVA with Tukey’s multiple comparisons test." 1216 1553 W2995142178.pdf 47 37 separator 0.69920707 20 ¶ 1554 1560 W2995142178.pdf 47 38 table 0.6214917 (G) Oral glucose tolerance test (OGTT, 2 g glucose/kg body weight) 25 -26 days 1560 1639 W2995142178.pdf 47 39 separator 0.8256642 21 ¶ 1639 1645 W2995142178.pdf 47 40 text 0.61654454 following administration of the first dose of STZ or acetate buffer; n= 5 -6 mice, *p < 0.05, 22 1645 1742 W2995142178.pdf 47 41 separator 0.41363564 1742 1743 W2995142178.pdf 47 42 paratext 0.9184511 . CC-BY 4.0 International licenseunder anot certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available The copyright holder for this preprint (which was this version posted November 15, 2019. ; https://doi.org/10.1101/480368doi: bioRxiv preprint 1743 2071 W2995142178.pdf 47 0 paratext 0.972264 "Vol. 1, No. 1, p. 129 -130 May 2014 ¶ DOI: 10.15353/cfs -rcea.v1i1.41 ISSN: 2292 -3071 129" 0 103 W2058992591.pdf 0 1 separator 0.69985396 "¶ ¶" 105 115 W2058992591.pdf 0 2 title 0.8969391 Book Review 116 128 W2058992591.pdf 0 3 separator 0.91868746 ¶ 130 132 W2058992591.pdf 0 4 title 0.9574148 "The Industrial Diet: The degradation of food and the struggle for healthy eating" 132 216 W2058992591.pdf 0 5 separator 0.88528025 ¶ 218 220 W2058992591.pdf 0 6 paratext 0.49326172 Anthony Winson 220 235 W2058992591.pdf 0 7 separator 0.5430137 ¶ 237 239 W2058992591.pdf 0 8 paratext 0.9082869 UBC Press, 2013: 352 pages 239 266 W2058992591.pdf 0 9 separator 0.49059248 ¶ 268 270 W2058992591.pdf 0 10 paratext 0.49784273 ¶ Review by 272 284 W2058992591.pdf 0 11 contact 0.5620188 Julie Pilson (Car 284 303 W2058992591.pdf 0 12 paratext 0.472424 leton 303 308 W2058992591.pdf 0 13 contact 0.48352197 University 308 319 W2058992591.pdf 0 14 paratext 0.5471517 ) 319 320 W2058992591.pdf 0 15 separator 0.84366053 "¶ ¶" 322 333 W2058992591.pdf 0 16 text 0.99935126 "Anthony Winson, a professor in the Department of Sociology and Anthropology at the University of Guelph, has written or co-authored several books that explore agriculture, food and the food system in both North and Central America. These books include: Coffee and Democ racy in Modern Costa Rica (1989), The Intimate Commodity (1993), and Contingent Work, Disrupted Lives: Labour and Community in the New Rural Economy (2002, with Belinda Leach). His most recent book builds on his previous analysis of the food industry by exploring the political, social, economic and technological factors that shape and influence the human diet—and have led to the proliferation of a nutritionally compromised human diet at a global scale. The Industrial Diet: The degradation of food and the struggle for healthy eating is a book best suited to an educated—though not necessarily academic—audience. Anybody with an interest in the current food industry, human health, diet and nutrition, or in the fascinating history of the food system, will fin d something of interest." 333 1407 W2058992591.pdf 0 17 separator 0.9893254 ¶ 1408 1410 W2058992591.pdf 0 18 text 0.9997627 Winson’s research and subsequent book are partially in response to the apparent crisis in human health referred to as the overweight and obesity epidemic. Winson seeks to expose the main causes of the degradation of our food supply and link these changes to human health and disease. He also examines the potential for action and the available solutions that could change our current food system. He identifies changes that could promote a food system that sustains the health of the population instead of simply the financial health of the food industry. In order to provide readers with the necessary background information, the book begins with a history of human diets and “dietary regimes”, including a discussion of the factors that have influenced dietary changes from Paleolithic times into the present day. The author explores the environmental, political, social, economic and technological conditions and innovations that have influenced the food supply throughout human history. Winson then explores more recent changes in food production that have resulted in the ongoing decline in nutritional health of our food supply, and the resultant health implications for the human population. To highlight the 1411 2635 W2058992591.pdf 0 19 separator 0.99242485 ¶ 2636 2638 W2058992591.pdf 0 0 paratext 0.9867355 Trans/Form/Ação, Marília, v. 41, p. 9-12, 2018, Edição Especial 9 0 65 W4252615596.pdf 0 1 separator 0.97588503 ¶ 65 67 W4252615596.pdf 0 2 title 0.93967265 Apresentação Editorial / Editorial 67 131 W4252615596.pdf 0 3 separator 0.6210328 ¶ 132 134 W4252615596.pdf 0 4 paratext 0.96276206 This is an open-access article distributed under the terms of the Creative Commons Attribution License.http://dx.doi.org/10.1590/0101-3173.2018.v41esp.02.p9Apresent Ação 135 305 W4252615596.pdf 0 5 separator 0.9953012 ¶ 305 307 W4252615596.pdf 0 6 text 0.9990482 "Este número especial de Trans/Form/Ação é dedicado ao tema “cons - ciência”, trazendo um amplo espectro de abordagens do fenômeno que con - temporaneamente se tornou alvo do interesse de investigadores em diversas áreas do conhecimento. Procuramos aqui ilustrar e tratar sistematicamente os principais enfoques filosóficos oferecidos no recorte, descrição, interpretação e tentativas de explicação do fenômeno, contemplando tanto as tradições conti - nentais quanto as analíticas." 307 805 W4252615596.pdf 0 7 separator 0.98863226 ¶ 805 807 W4252615596.pdf 0 8 text 0.99950886 "O primeiro artigo, de autoria de Manuel Moreira da Silva, resgata uma abordagem ontológica da consciência, da tradição aristotélica e neo-platônica, que pretende superar as abordagens modernas, as quais se centram no conceito de representação mental. Enveredando nesta direção, o trabalho de Manuel termina por aproximar os filósofos antigos de contemporâneos como Heide - gger e teóricos psicodinâmicos. O conceito de “manência” é utilizado, nesta abordagem, para expressar a intimidade da consciência com o ser." 807 1338 W4252615596.pdf 0 9 separator 0.98412496 ¶ 1339 1341 W4252615596.pdf 0 10 text 0.99947643 "No segundo artigo, Sam Coleman discute a teoria HOT (higher-order thought; vide Rosenthal, 2006), que defende a concepção moderna de cons - ciência, na qual esta se formaria por meio de pensamentos a respeito de estados mentais, os quais podem ser de natureza cognitiva ou emocional. A expressão da consciência se faria cognitivamente, ou seja, em conceitos , que se formam espontaneamente e são comunicados por meio da linguagem verbal. Em sua nova versão da teoria HOT, a teoria “citacional” ( quotational HOT ), que parte de objeções apresentadas a partir do trabalho de Ned Block e Uriah Kriegel, Coleman argumenta por um processo não-representacional de segunda or - dem, constitutivo da experiência consciente, pelo qual os processos represen -" 1341 2119 W4252615596.pdf 0 0 text 0.9992649 "western countries wher e this study detected it in only 1 fetus of Rus sian women and our 2nd commonest major malformations were detected in the Urinary tract 24/7552(20.16%). Accor ding to a study published in the Journal of Pakistan Medical Association in 2015, the incidence of neural tube defects in Pakistan was repor ted to be ar ound 5.6 per 1, 000 liv e bir ths [22] B ut in this study , the incidence found to be higher (approx. 18.18% in 3 trimest ers). Overall, the incidence was lower in trimest ers individually and this may be because of folate supplementation in the last few years as a part of the healthcar e system in Pakistan . But ther e is a need to study this further at multi-center and especially in areas of malnutrition in the countr y. Since ther e were no neural tube defects, we were unable to associat e it with folat e, drug, and supplementar y products, though other socie ties and populations did repor t the association before." 0 1009 W4388949142.pdf 5 1 separator 0.9956567 ¶ 1009 1011 W4388949142.pdf 5 2 bibliography 0.99771583 "Mahapatra AK, Suri A. Anterior encephaloceles: a study of 92 cases. Pediatric neur osur gery. 2002 Mar; 36(3): 113-8. doi: 10.1159/000048365." 1011 1159 W4388949142.pdf 5 3 separator 0.97686416 ¶ 1159 1161 W4388949142.pdf 5 4 bibliography 0.99512845 "Cicero S, Bindra R, Rembouskos G, Tripsanas C, Nicolaides KH. Fetal nasal bone length in PJHS V OL. 4 Is sue . 10 Oct ober 202" 1161 1294 W4388949142.pdf 5 5 paratext 0.91933954 3 Copyright © 2023. PJHS , Published by Cros slinks Int ernational Publisherschromosomally normal 1294 1392 W4388949142.pdf 5 6 bibliography 0.55541164 and abnormal fetuses at 1392 1416 W4388949142.pdf 5 7 paratext 0.52935046 11–14 1416 1422 W4388949142.pdf 5 8 bibliography 0.5824647 ¶ weeks of gestation 1423 1445 W4388949142.pdf 5 9 paratext 0.5927299 . The Journal of Mat ernal-F 1445 1473 W4388949142.pdf 5 10 bibliography 0.48592365 et 1473 1476 W4388949142.pdf 5 11 paratext 0.53346914 al & 1476 1480 W4388949142.pdf 5 12 bibliography 0.62260437 ¶ Neonatal Medicine . 1481 1503 W4388949142.pdf 5 13 paratext 0.6324104 2002 Jan 1503 1512 W4388949142.pdf 5 14 bibliography 0.52046347 ; 1512 1513 W4388949142.pdf 5 15 paratext 0.5998758 11(6) 1513 1519 W4388949142.pdf 5 16 bibliography 0.6795734 1519 1520 W4388949142.pdf 5 17 paratext 0.5227233 :400-2. doi 1520 1531 W4388949142.pdf 5 18 bibliography 0.51674044 : 1531 1532 W4388949142.pdf 5 19 paratext 0.4945227 10. 1532 1536 W4388949142.pdf 5 20 bibliography 0.5694065 ¶ 1537 1539 W4388949142.pdf 5 21 paratext 0.7255465 1080/jmf .11.6.400.402 1539 1562 W4388949142.pdf 5 22 separator 0.9923523 ¶ 1562 1564 W4388949142.pdf 5 23 paratext 0.6820393 Sn 1564 1567 W4388949142.pdf 5 0 text 0.9994364 "These arguments have been criticized by a number of anthropologists. At the time, some argued that looking for such large-scale processes –from colonial rule to neoliber- alism to modernity –was a way of turning a ‘general context into [a] particular explanation ’ (Moore 1999 , 306; cf. Englund and Leach 2000 ). Instead, anthropologists should contextua- lize rumours in relation to local social situations and practices. This is an enduring and understandable anthropological response to large-scale analyses and, consequently, anumber of anthropologists have attempted to situate the emergence of vampirerumours and witchcraft accusations in relation to smaller-scale dynamics such as local forms of inequality and ‘social tensions ’of various kinds (see, for example, Geissler 2005 ). However, even these more fine-grained ethnographic analyses have not satis fied critics who have taken up a di fferent line of argument. In recent years, many anthropolo- gists have argued that these approaches are ‘reductionist ’because they attempt to explain the presence of vampires, zombies, witches (and other entities) in people ’s lives in relation to other more ‘real’processes, structures and political realities: whether this is colonial rule, neoliberalism, or modernity (see, for example, Pedersen 2011 ; Scherz 2018 ; West 2007 )." 0 1355 W2999848269.pdf 6 1 separator 0.98843896 ¶ 1355 1357 W2999848269.pdf 6 2 text 0.9996183 "Instead, when we encounter people discussing the presence of vampires (or other entities) in their lives, we should take seriously their ontological claims about the reality of these actors rather than assuming that these are figurative or metaphorical claims that must ulti- mately be about something else (see also Holbraad and Pedersen 2018 )." 1357 1709 W2999848269.pdf 6 3 separator 0.98542655 ¶ 1709 1711 W2999848269.pdf 6 4 text 0.9997278 "These persuasive criticisms have been infl uential within the discipline. Indeed, it does seem that scholars of vampires, witches, and other entities have failed to take seriouslythe reality of these non-human actors in people ’s lives by regarding them principally as metaphorical commentaries on other realities. However, one of the consequences of these debates is that anthropologists have arguably become preoccupied with theoreti- cally convoluted discussions about reductionism and ontology (for example, Ellis 2015 )." 1711 2244 W2999848269.pdf 6 5 separator 0.98051256 ¶ 2244 2246 W2999848269.pdf 6 6 text 0.99880105 "And these kinds of anthropological debates can obscure a di fferent –and I think more interesting –problem with much of the scholarship on vampires and biomedicine in Africa: namely, that it paints a picture in which African populations have responded to bio- medical interventions in uniformly morally negative terms. Whether vampires are a realityin people ’s lives or a metaphorical language for describing other realities, the fact is that they are troubling and morally harmful entities. Historians and anthropologists have tended to focus their attention on the figure of the vampire alone –whether this is the mumiani ,kachinja ormunyama –and therefore the reception to new biomedical interven- tions seems to be relentlessly and enduringly negative. This ultimately prevents us fromcapturing the profound moral ambivalence at stake in responses to humanitarian biome- dicine in the region. However, when we consider that vampires have not been the onlynon-human entities associated with biomedicine, it becomes possible instead to identify the more interestingly ambivalent attitudes that people have adopted towards humanitar- ian biomedicine. In the next section, I outline the history of southern Zambia and the pres- ence of banyam awithin this history before considering how the figure of the angel might complicate this history." 2246 3613 W2999848269.pdf 6 7 separator 0.9963154 ¶ 3613 3615 W2999848269.pdf 6 8 title 0.9814405 White Europeans and banyama 3615 3643 W2999848269.pdf 6 9 separator 0.9928031 ¶ 3643 3645 W2999848269.pdf 6 10 text 0.99684143 "Thefirst Europeans to settle permanently in the region of present-day southern Zambia were agents of the British South Africa Company (BSAC) who governed from the 1890s222 J. WINTRUP" 3645 3829 W2999848269.pdf 6 0 paratext 0.96849924 "Citation: Truneh, L.A.; Matula, S.; Bát’ková, K. Hydroclimate Impact Analyses and Water Management in the Central Rift Valley Basin in Ethiopia. Water 2023 ,15, 18. https:// doi.org/10.3390/w15010018" 0 209 W4312187908.pdf 0 1 separator 0.939375 ¶ 209 211 W4312187908.pdf 0 2 paratext 0.6138823 Academic Editor: 211 228 W4312187908.pdf 0 3 contact 0.8312854 "Adriana Bruggeman" 228 248 W4312187908.pdf 0 4 paratext 0.93166703 "¶ Received: 12 October 2022 Revised: 14 December 2022 Accepted: 15 December 2022 Published: 21 December 2022" 248 363 W4312187908.pdf 0 5 separator 0.8083687 ¶ 363 365 W4312187908.pdf 0 6 paratext 0.9364338 "Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)." 365 632 W4312187908.pdf 0 7 separator 0.9456384 ¶ 632 634 W4312187908.pdf 0 8 paratext 0.72407794 water 634 640 W4312187908.pdf 0 9 separator 0.8121891 ¶ 640 642 W4312187908.pdf 0 10 title 0.9683169 Article 642 650 W4312187908.pdf 0 11 separator 0.7090336 ¶ 650 652 W4312187908.pdf 0 12 title 0.985676 "Hydroclimate Impact Analyses and Water Management in the Central Rift Valley Basin in Ethiopia" 652 749 W4312187908.pdf 0 13 separator 0.9875922 ¶ 749 751 W4312187908.pdf 0 14 contact 0.9928177 "Lemma Adane Truneh * , Svatopluk Matula and Kamila B át’kov á Department of Water Resources, Faculty of Agrobiology Food and Natural Resources, Czech University of Life Sciences Prague, Kam ýcká129, Suchdol, 165 00 Prague, Czech Republic *Correspondence: truneh@af.czu.cz" 751 1035 W4312187908.pdf 0 15 separator 0.9937138 ¶ 1035 1037 W4312187908.pdf 0 16 text 0.99038035 "Abstract: This study explores the impacts of climate change on the major components of the water balance such as surface runoff (Q), water yield (WY), and evapotranspiration (ET) in the Central Rift Valley Basin (CRVB) in Ethiopia. Projected climate data from the climate emission scenarios were used for the analyses. Representative concentration pathway (RCP) data from the MIROC-RCA4 ensemble driving climate models were downscaled, bias-corrected, and applied for impact analyses." 1037 1530 W4312187908.pdf 0 17 separator 0.60287166 ¶ 1530 1532 W4312187908.pdf 0 18 text 0.9983328 "Climate scenario analyses for the near-term (2031–2060) and long-term (2070–2099) periods were used to assess the conditions of the water balance components. The endo hydrogenic CRVB was divided into three sub-basins, and their respective hydroclimatic impacts were simulated separately with calibrated Arc-SWAT models. The future impacts simulated on the annual average basis vary in their maximum ranges from" 1532 1951 W4312187908.pdf 0 0 paratext 0.97386926 "www.ccsenet.org/ass Asian Social Science V ol. 11, No. 15; 2015 258" 0 71 W1540982974.pdf 1 1 separator 0.9779115 ¶ 72 74 W1540982974.pdf 1 2 title 0.9933503 2. Teacher Beliefs and Grammar Teaching 75 115 W1540982974.pdf 1 3 separator 0.9950742 ¶ 116 118 W1540982974.pdf 1 4 text 0.99965596 "Studies on the beliefs of ESL teachers in Malaysia in th e teaching of grammar in thei r ESL classrooms have been few and far between. This is not surprising as Borg (2006) pointed out that there is a lack of explicit discussion in the literature on the study of beliefs in teaching among teachers. He consider s such studies to be “different to the study of related psychological constructs such as knowledge, conceptions and attitudes.” As Richards (1998: 51-52) acknowledges, the teachers’ belief systems are “s table sources of re ference which are built gradually over the years they are teaching and are rela ted to the teaching dimensions such as the teachers’ theory of language, the nature of language teaching, the role of the teacher, effective teaching practices and teacher-student relations.”" 118 946 W1540982974.pdf 1 5 separator 0.9432881 ¶ 947 949 W1540982974.pdf 1 6 text 0.99967015 "In short, it is likely that it is the teachers’ beliefs that will determin e how enthusiastically they teach in the classroom as well as how effec tive they may be in teaching their students. The lack of studies in this particular area in the Malaysian education system, therefore, prevents educators and re searchers alike from a useful source of reference." 949 1317 W1540982974.pdf 1 7 separator 0.9878787 ¶ 1318 1320 W1540982974.pdf 1 8 text 0.99972314 "In trying to understand the influence of teachers’ beliefs on teaching, it is important to identify factors that may shape teacher beliefs. Eisentein-Ebsworth and Schweers (1997) claim that when it comes to “articulating their rationales, teachers referred to various factors shaping their views, such as student wants, and syllabus expectations” (p. 255). Richar ds (1998) lists down two different types of knowledge that ma y influence teachers’ understanding and practice of teaching. The first concer ns the curricular goals, lesson plans, instructional activities, materials, tasks, and teaching techniques. The other relates to teacher s’ personal and subjective philosophies and their und erstanding of what constitute good teaching (Richards, 1998 : 51). Moini (2009) notes that teachers’ social construct, whic h results from their personal experi ences and influences from their work setting, play a role in the development of their beliefs." 1320 2295 W1540982974.pdf 1 9 separator 0.973117 ¶ 2297 2299 W1540982974.pdf 1 10 text 0.999745 "Through his extensive review of studies on beliefs, Borg (2003) insists that the studies on practicing teachers “provide further support for the belief that prior learning expe rience shapes teachers’ c ognitions and instructional decisions” (p. 88). Other previous studies have also shown that teachers’ prior knowledge as learners with their previous ESL teachers plays an important role in shaping their current teaching beliefs regarding the teaching of grammar. In the same vein, Nespor (1 987) found that th e teachers may be influenced by a “crucial experience or some particularly influential teacher produces a richly-detailed episodic me mory which later serves the student as an inspiration and a template for his or her own teac hing practices” (p. 320). Expe rience as learners has also been identified by Abdullah and Majid (2013) as one of the potential sources of beliefs, besides perceptions towards the students, institutional environment and practi ce and personal views on current practice in their study on Malaysian ESL teachers (p. 821). The results of these studies are echoed by Ezzi’s statement on the complexity of the beliefs that teach ers possess that “are likely to be de rived from their prior experience of teaching English” ( 2012, p. 170)." 2299 3607 W1540982974.pdf 1 11 separator 0.98677886 ¶ 3609 3611 W1540982974.pdf 1 12 text 0.9996648 "The importance of beliefs in a teache r’s practice in the classroom cannot be ignored. Shavelson and Stern (1981) indicate that teachers’ action in the class is governed by their beliefs. According to Moini (2009), the teachers’ belief system consists of “the information, attitudes, va lues, theories, and assumptions about teaching, learning, learners, and other aspects of teaching” (p. 143). The teachers’ beliefs on th e teaching of grammar help them to “form part of the process of understanding how to conceptualize their work” (Richards, Gallo and Renandya, 2001, p. 42). These show the vitality of the role of ESL teachers’ beliefs ’ in the process of making decisions involving the contents of the lesson, the depth of the lesson, the methodology used and other aspects of language teaching in their ESL grammar classroom." 3611 4466 W1540982974.pdf 1 13 separator 0.98664737 ¶ 4467 4469 W1540982974.pdf 1 14 text 0.99971277 "The teachers’ effectiveness at delivering the grammar lessons to their ESL classrooms can clearly be affected by their beliefs regarding the teaching of grammar. Richards mentioned that one of the two types of knowledge that can play an influential role in how e ffective the teacher will be in the classroom, is teach ers’ personal view of teaching (Richards, 1998, p. 51). Their beliefs are not formed loosely and do not just influence one aspect of the grammar teaching but also act as a f ilter to their instructional judgement s and decision making in class and subsequently provide a “systematic justification process wi th which to plan, assess, j udge, decide, accept, deny or act (Ezzi, 2012, p. 172). However, although Ezzi (2012) found that while the teachers’ beliefs may have a very significant relationship to the suggested strategi es of teaching grammar, when it comes to the actual teaching, the beliefs are not actually refl ected in their classroom practices. This is the reason why it is crucial to conduct more studies in this area as it will provide valuable info rmation that may be used to sensitize teachers to their own beliefs in order to improve classroom pedagogy as well as to inform teacher trainers and administrators on how best to ensure that effective grammar t eaching is constantly provided in the classroom." 4469 5848 W1540982974.pdf 1 0 paratext 0.9871678 Int. J. Mol. Sci. 2020 ,21, 5426 8 of 10 0 40 W3045574101.pdf 7 1 separator 0.9874524 ¶ 40 42 W3045574101.pdf 7 2 bibliography 0.983187 "13. Kochevar, I.E. Cytotoxicity and mutagenicity of excimer laser radiation. Lasers Surg. Med. 1989 ,9, 440–445. [CrossRef]" 42 168 W3045574101.pdf 7 3 separator 0.95103383 ¶ 168 170 W3045574101.pdf 7 4 bibliography 0.9979921 "14. Tanaka, Y.; Nakayama, J. Upregulated epidermal growth factor receptor expression following near-infrared irradiation simulating solar radiation in a three-dimensional reconstructed human corneal epithelial tissue culture model. Clin. Interv. Aging 2016 ,11, 1027–1033. [CrossRef] [PubMed]" 170 467 W3045574101.pdf 7 5 separator 0.94992316 ¶ 467 469 W3045574101.pdf 7 6 bibliography 0.9980616 "15. Mesa, R.; Bassnett, S. UV-B-Induced DNA damage and repair in the mouse lens. Invest. Ophthalmol. Vis. Sci. 2013 ,54, 6789. [CrossRef]" 469 609 W3045574101.pdf 7 7 separator 0.93447155 ¶ 609 611 W3045574101.pdf 7 8 bibliography 0.9980308 "16. Behar-Cohen, F.; Baillet, G.; de Ayguavives, T.; Garcia, P .O.; Krutmann, J.; Peña-Garc ía, P .; Reme, C.; Wolsohn, J.S. Ultraviolet damage to the eye revisited: Eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin. Ophthalmol. 2014 ,8, 87–104. [CrossRef]" 611 912 W3045574101.pdf 7 9 separator 0.9208524 ¶ 912 914 W3045574101.pdf 7 10 bibliography 0.9980986 17. Youssef, P .N.; Sheibani, N.; Albert, D.M. Retinal light toxicity. Eye (Lond) 2011 ,25, 1–14. [CrossRef] 914 1023 W3045574101.pdf 7 11 separator 0.8759853 ¶ 1023 1025 W3045574101.pdf 7 12 bibliography 0.998108 "18. Ortwerth, B.J.; Bhattacharyya, J.; Shipova, E. Tryptophan metabolites from young human lenses and the photooxidation of ascorbic acid by UVA light. Invest. Ophthalmol. Vis. Sci. 2009 ,50, 3311–3319. [CrossRef]" 1025 1241 W3045574101.pdf 7 13 separator 0.9034133 ¶ 1241 1243 W3045574101.pdf 7 14 bibliography 0.99813634 "19. An, M.-J.; Kim, C.-H.; Nam, G.-Y.; Kim, D.-H.; Rhee, S.; Cho, S.-J.; Kim, J.-W. Transcriptome analysis for UVB-induced phototoxicity in mouse retina. Environ. Toxicol. 2018 ,33, 52–62. [CrossRef]" 1243 1445 W3045574101.pdf 7 15 separator 0.90257573 ¶ 1445 1447 W3045574101.pdf 7 16 bibliography 0.99809664 "20. Gaillard, E.R.; Zheng, L.; Merriam, J.C.; Dillon, J. Age-related changes in the absorption characteristics of the primate lens. Invest. Ophthalmol. Vis. Sci. 2000 ,41, 1454–1459." 1447 1632 W3045574101.pdf 7 17 separator 0.8953575 ¶ 1632 1634 W3045574101.pdf 7 18 bibliography 0.99804246 "21. Gaillard, E.R.; Merriam, J.; Zheng, L.; Dillon, J. Transmission of light to the young primate retina: Possible implications for the formation of lipofuscin. Photochem. Photobiol. 2011 ,87, 18–21. [CrossRef] [PubMed]" 1634 1856 W3045574101.pdf 7 19 separator 0.93600833 ¶ 1856 1858 W3045574101.pdf 7 20 bibliography 0.99791956 "22. Cejkov á, J.; St ípek, S.; Crkovsk á, J.; Ardan, T.; Pl áteník, J.; Cejka, C.; Midelfart, A. UV Rays, the prooxidant /antioxidant imbalance in the cornea and oxidative eye damage. Physiol. Res. 2004 ,53, 1–10. [PubMed]" 1858 2085 W3045574101.pdf 7 21 separator 0.94162595 ¶ 2085 2087 W3045574101.pdf 7 22 bibliography 0.99808633 "23. Cejka, C.; Pl áteník, J.; Guryca, V .; Sirc, J.; Mich álek, J.; Br ̊ unov á, B.; Cejkov á, J. Light absorption properties of the rabbit cornea repeatedly irradiated with UVB rays. Photochem. Photobiol. 2007 ,83, 652–657. [CrossRef]" 2087 2325 W3045574101.pdf 7 23 separator 0.9192015 ¶ 2325 2327 W3045574101.pdf 7 24 bibliography 0.99290633 "24. Podskochy, A.; Gan, L.; Fagerholm, P . Apoptosis in UV-exposed rabbit corneas. Cornea 2000 ,19, 99–103. [CrossRef]" 2327 2448 W3045574101.pdf 7 25 separator 0.93746245 ¶ 2448 2450 W3045574101.pdf 7 26 bibliography 0.9979961 "25. Sidjanin, D.; Zigman, S.; Reddan, J. DNA damage and repair in rabbit lens epithelial cells following UVA radiation. Curr. Eye Res. 1993 ,12, 773–781. [CrossRef] [PubMed]" 2450 2626 W3045574101.pdf 7 27 separator 0.90536946 ¶ 2626 2628 W3045574101.pdf 7 28 bibliography 0.998065 "26. Hammond, B.R., Jr.; Renzi-Hammond, L. Individual variation in the transmission of UVB radiation in the young adult eye. PLoS ONE 2018 ,13, e0199940. [CrossRef]" 2628 2794 W3045574101.pdf 7 29 separator 0.91137505 ¶ 2794 2796 W3045574101.pdf 7 30 bibliography 0.9977108 "27. Cejkov á, J.; St ípek, S.; Crkovsk á, J.; Ardan, T.; Midelfart, A. Reactive oxygen species (ROS)-generating oxidases in the normal rabbit cornea and their involvement in the corneal damage evoked by UVB rays. Histol. Histopathol. 2001 ,16, 523–533." 2796 3053 W3045574101.pdf 7 31 separator 0.96553266 ¶ 3053 3055 W3045574101.pdf 7 32 bibliography 0.99804586 "28. Cejkov á, J.; Ardan, T.; Filipec, M.; Midelfart, A. Xanthine oxidoreductase and xanthine oxidase in human cornea. Histol. Histopathol. 2002 ,17, 755–760." 3055 3215 W3045574101.pdf 7 33 separator 0.9408898 ¶ 3215 3217 W3045574101.pdf 7 34 bibliography 0.998108 "29. Buddi, R.; Lin, B.; Atilano, S.R.; Zorapapel, N.C.; Kenney, M.C.; Brown, D.J. Evidence of oxidative stress in human corneal diseases. J. Histochem. Cytochem. 2002 ,50, 341–351. [CrossRef]" 3217 3411 W3045574101.pdf 7 35 separator 0.90349925 ¶ 3411 3413 W3045574101.pdf 7 36 bibliography 0.99808973 "30. Najjar, D.M.; Awwad, S.T.; Zein, W.M.; Haddad, W.F. Assessment of the corneal endothelium in acute ultraviolet keratitis. Med. Sci. Monit. 2006 ,12, MT23–MT25." 3413 3579 W3045574101.pdf 7 37 separator 0.94467807 ¶ 3579 3581 W3045574101.pdf 7 38 bibliography 0.9973733 "31. Vizzarri, F.; Palazzo, M.; Bartollino, S.; Casamassima, D.; Parolini, B.; Troiano, P .; Caruso, C.; Costagliola, C. Eects of an antioxidant protective topical formulation on eye exposed to ultraviolet-irradiation: A study in rabbit animal model. Physiol. Res. 2018 ,67, 457–464. [CrossRef]" 3581 3880 W3045574101.pdf 7 39 separator 0.9413493 ¶ 3880 3882 W3045574101.pdf 7 40 bibliography 0.997969 "32. Cejka, C.; Cejkova, J. Oxidative stress to the cornea, changes in corneal optical properties, and advances in treatment of corneal oxidative injuries. Oxid. Med. Cell. Longev. 2015 ,2015 , 1–10. [CrossRef] [PubMed]" 3882 4103 W3045574101.pdf 7 41 separator 0.94990814 ¶ 4103 4105 W3045574101.pdf 7 42 bibliography 0.9980262 "33. Wakamatsu, T.H.; Dogru, M.; Ayako, I.; Takano, Y.; Matsumoto, Y.; Ibrahim, O.M.A.; Okada, N.; Satake, Y.; Fukagawa, K.; Shimazaki, J.; et al. Evaluation of lipid oxidative stress status and inflammation in atopic ocular surface disease. Mol. Vis. 2010 ,16, 2465–2475. [PubMed]" 4105 4389 W3045574101.pdf 7 43 separator 0.9133059 ¶ 4389 4391 W3045574101.pdf 7 44 bibliography 0.99732786 "34. Seen, S.; Tong, L. Dry eye disease and oxidative stress. Acta Ophthalmol. 2018 ,96, e412–e420. [CrossRef] [PubMed]" 4391 4512 W3045574101.pdf 7 45 separator 0.95640945 ¶ 4512 4514 W3045574101.pdf 7 46 bibliography 0.998005 "35. Zigman, S.; McDaniel, T.; Schultz, J.B.; Reddan, J.; Meydani, M. Damage to cultured lens epithelial cells of squirrels and rabbits by UV-A (99.9%) plus UV-B (0.1%) radiation and alpha tocopherol protection. Mol. Cell. Biochem. 1995 ,143, 35–46. [CrossRef]" 4514 4778 W3045574101.pdf 7 47 separator 0.9459925 ¶ 4778 4780 W3045574101.pdf 7 48 bibliography 0.99806005 36. Yam, J.C.S.; Kwok, A.K.H. Ultraviolet light and ocular diseases. Int. Ophthalmol. 2014 ,34, 383–400. [CrossRef] 4780 4896 W3045574101.pdf 7 0 paratext 0.97387093 "Jurnal Interprofesi Kesehatan Indonesia Vol. 2, No. 4, September 2023, pp. 354-359 ISSN 2807 -7563 (print), ISSN 2807 -7571 (online) Journal homepage https://jurnalinterprofesi.com/index.php/jipki Fitriyah | 358" 0 229 W4386754105.pdf 4 1 separator 0.9882541 ¶ 230 232 W4386754105.pdf 4 2 bibliography 0.49969733 Nilai 232 238 W4386754105.pdf 4 3 text 0.4612257 Asymp 238 244 W4386754105.pdf 4 4 bibliography 0.49143088 . 244 245 W4386754105.pdf 4 5 text 0.4905447 Sig 245 249 W4386754105.pdf 4 6 bibliography 0.5045377 . 249 250 W4386754105.pdf 4 7 text 0.44779456 (2 250 253 W4386754105.pdf 4 8 bibliography 0.5027554 253 254 W4386754105.pdf 4 9 text 0.46980393 -tail 254 259 W4386754105.pdf 4 10 bibliography 0.4848926 ed) sebesar 0,647 259 277 W4386754105.pdf 4 11 text 0.4316882 > 277 279 W4386754105.pdf 4 12 bibliography 0.61412114 0,05 sehingga keputusan hipote 279 310 W4386754105.pdf 4 13 text 0.4363195 sis 310 313 W4386754105.pdf 4 14 bibliography 0.5586465 Ha ditolak 313 324 W4386754105.pdf 4 15 text 0.6142971 . 324 325 W4386754105.pdf 4 16 separator 0.99427253 ¶ 326 328 W4386754105.pdf 4 17 title 0.65783805 "Tidak ada pengaruh WhatsApp Group (WAG) terhadap Self Regulation remaja dengan gejala anemia di Sari Farma Depok" 328 447 W4386754105.pdf 4 18 text 0.6048932 . 447 448 W4386754105.pdf 4 19 separator 0.9900072 ¶ 450 452 W4386754105.pdf 4 20 text 0.9889015 "Penelitian ini sejalan dengan penelitian yang dilakukan oleh (Nengah Runiari & I Dewa Made Ruspawan) tentang “Media Video dan WhatsApp Rimender Terhadap Kepatuhan Remaja Putri Minum Tablet Tambah Darah”. Penelitian ini menggunakan 74 responden kelompok intervensi dan 74 responden kelompok kontrol. Penelitian ini menggunakan Uji Mann Whitney U-Tes dengan hasil Ada pengaruh edukasi kesehatan menggunakan video dan Whatssapp Reminder berpengaruh terhadap pengetahuan responden (p=0.000). Nilai rata -rata pengetahuan lebih tinggi pada kelompok perlakuan (10.61, SD=1.077) dibandingkan dengan kelompok kontrol (9.69, SD=1.077).15" 452 1102 W4386754105.pdf 4 21 separator 0.98796487 ¶ 1103 1105 W4386754105.pdf 4 22 text 0.9970165 "Hasil penelitian secara statistic menunjukan tidak ada perbedaan self regulation remaja dengan gejala anemia dengan media WhatsApp Group (WAG) meskipun skor rata -rata kelompok eksperimen mengalami penurunan dibandingkan skor rata -rata kelompok kontrol." 1105 1368 W4386754105.pdf 4 23 separator 0.62046075 ¶ 1369 1371 W4386754105.pdf 4 24 text 0.997431 "Hal ini menunjukan bahwa perlakuan edukasi melalui WhatsApp Group (WAG) untuk meningkatkan self regulation remaja dengan gejala anemia memberikan dampak positif terhadap peningkatan self regulation." 1371 1578 W4386754105.pdf 4 25 separator 0.99668765 ¶ 1581 1583 W4386754105.pdf 4 26 title 0.9869375 Kesimpulan 1583 1594 W4386754105.pdf 4 27 separator 0.99519813 ¶ 1596 1598 W4386754105.pdf 4 28 text 0.9982552 "Berdasarkan hasil penelitian yang telah dilakukan tentang pengaruh WhatsApp Group terhadap self regulation pada remaja dengan gejala anemia di SMK Sari Farma Depok Tahun 2021 dengan jumlah 30 responden, maka dapat disimpulkan bahwa Tidak ada pengaruh WhatsApp Group terhadap self regulation pada remaja dengan gejala anemia di SMK Sari Farma Depok Tahun 2021 . Adanya peningkatan skor rata -rata self regulation remaja terhadap gejala anemia setelah edukasi WhatsApp Group." 1598 2096 W4386754105.pdf 4 29 separator 0.9961469 ¶ 2097 2099 W4386754105.pdf 4 30 title 0.9886177 Konflik Kepentingan 2099 2119 W4386754105.pdf 4 31 separator 0.9857042 ¶ 2121 2123 W4386754105.pdf 4 32 text 0.9964629 "Peneliti menyatakan bahwa penelitian ini independen dari konflik kepentingan individu dan organisasi" 2123 2227 W4386754105.pdf 4 33 separator 0.9946077 ¶ 2229 2231 W4386754105.pdf 4 34 title 0.9877282 Ucapan Terima Kasih 2231 2251 W4386754105.pdf 4 35 separator 0.9901637 ¶ 2253 2255 W4386754105.pdf 4 36 text 0.993337 "Ucapan terima kasih kepada STIKIM dan SMK Sari Farma Depok yang telah membantu dan memfasilitasi kegiatan penelitian ini." 2255 2381 W4386754105.pdf 4 37 separator 0.9945668 ¶ 2383 2385 W4386754105.pdf 4 38 title 0.9824996 Pendanaan 2385 2395 W4386754105.pdf 4 39 separator 0.98789996 ¶ 2397 2399 W4386754105.pdf 4 40 text 0.9959986 Sumber keuangan dalam penelitian ini yaitu dari peneliti. 2399 2458 W4386754105.pdf 4 41 separator 0.9958705 ¶ 2460 2462 W4386754105.pdf 4 42 title 0.8993299 References 2462 2473 W4386754105.pdf 4 43 separator 0.9874237 ¶ 2475 2477 W4386754105.pdf 4 44 bibliography 0.99706703 1. S. P. Gizi Remaja Putri Plus 1000 Hari Pertama Kehidupan. Bandung; 2017. 2477 2554 W4386754105.pdf 4 45 separator 0.67054474 ¶ 2556 2558 W4386754105.pdf 4 46 bibliography 0.99762785 "2. Hidayati KB, Farid M. Konsep diri, adversity quotient dan penyesuaian diri pada remaja. Pers J Psikol Indones. 2016;5(02):137 –44." 2558 2696 W4386754105.pdf 4 47 separator 0.9326885 ¶ 2698 2700 W4386754105.pdf 4 48 bibliography 0.99752986 3. Proverawati A. Anemia dalam Kehamilan. Nuha Med Yogyakarta. 2013; 2700 2770 W4386754105.pdf 4 49 separator 0.8275696 ¶ 2772 2774 W4386754105.pdf 4 50 bibliography 0.99682134 "4. Putri R, Bengkulu K. A nalysis Of Diet And Iron Deficiency Anemia In Adolescent Girls City . 2015;11 – 8." 2774 2886 W4386754105.pdf 4 51 separator 0.8855386 ¶ 2888 2890 W4386754105.pdf 4 52 bibliography 0.9968012 "5. Riskesdas. Hasil Utama Riset Kesehatan Dasar. Kementrian Kesehatan Republik Indonesia. 2018. 1 –100 p." 2890 3000 W4386754105.pdf 4 53 separator 0.9733267 ¶ 3002 3004 W4386754105.pdf 4 54 bibliography 0.99749136 "6. Mulya H, Sumargi A. Self -Regulation dan Perilaku Makan Sehat Mahasiswa yang Mengalami Dyspepsia. Experientia. 2016;4(2):65 –74." 3004 3140 W4386754105.pdf 4 55 separator 0.965801 ¶ 3142 3144 W4386754105.pdf 4 56 bibliography 0.9975842 7. Briawan D. Anemia: masalah gizi pada remaja wanita. In EGC; 2014. 3144 3214 W4386754105.pdf 4 0 paratext 0.9659383 Acta Cirúrgica Brasileira - Vol 20 (5) 2005 - 373Comp 0 53 W2057126774.pdf 5 1 title 0.98984575 ensatory lung growth in autologus lobar implant after pneumonectomy in dogs 53 128 W2057126774.pdf 5 2 separator 0.9895627 ¶ 128 130 W2057126774.pdf 5 3 text 0.9975623 "reduced 7 days after surgery in rats despite normalized RV , but on the 30th day it was normal13. Other authors have shown that this compensation may occur before the 14th postoperative day in rats10. Perhaps TLC compensation time in dogs is longer than our study period, this is why it wasnot detected." 130 442 W2057126774.pdf 5 4 separator 0.9959152 ¶ 442 444 W2057126774.pdf 5 5 title 0.7333666 Lung scintigraphy 444 462 W2057126774.pdf 5 6 text 0.9984981 "In the control group, despite higher captation in the right lung, it was not significantly different from the left butin operated animals the right lung captation wassignificantly higher than the left. Scintigraphy did not detectCLG and no correlation was found between scintigraphyand lung mass and volume in any group; this demonstratesthat perfusion scintigraphy under these conditions is notrepresentative of lung parenchyma levels. One reason thatmay alter the result in operated dogs is anaesthesia, becauseto perform scintigraphy dogs were previously anaesthetizedwhich leads to a superficial breathing" 462 1073 W2057126774.pdf 5 7 separator 0.9908527 ¶ 1073 1075 W2057126774.pdf 5 8 text 0.97704804 "1. As the left lung in operated animals had less compliance than the right,ventilation damage to the left was much higher and by theEuler and Liljestrandt law, perfusion should also decreasewhich would lead to reduced radionuclide drug captationby the left lung." 1075 1340 W2057126774.pdf 5 9 separator 0.9566564 ¶ 1340 1342 W2057126774.pdf 5 10 text 0.99860543 "There are other factors influencing captation besides compliance because in controls there was no significantcorrelation between captation with scintigraphy and lungvolume and mass, and one of the elements that can influencethis result is decubitus because lung perfusion depends ongravity." 1342 1635 W2057126774.pdf 5 11 separator 0.9951688 ¶ 1635 1637 W2057126774.pdf 5 12 title 0.8950463 Conclusion 1637 1648 W2057126774.pdf 5 13 text 0.9969286 "There is CLG in transplanted lobe and lung contralateral to transplant, but lung compliance is still reduced fivemonths after surgery. In lobectomized and transplantedanimals CLG of contralateral lung was similar but on theoperated side reimplanted lobe lung compliance is muchmore prejudiced than the lobe remaining after lobectomy." 1648 1983 W2057126774.pdf 5 14 separator 0.9957819 ¶ 1983 1985 W2057126774.pdf 5 15 paratext 0.47546166 Reference 1985 1995 W2057126774.pdf 5 16 title 0.54013 s 1995 1996 W2057126774.pdf 5 17 separator 0.9864825 ¶ 1996 1998 W2057126774.pdf 5 18 bibliography 0.995444 "1. Nagao RK, Cataneo AJM. Autologus lobar lung implant after pneumonectomy: experimental model in dogs. Acta Cir Bras. [serial on the Internet] 2005 July-Aug;20(4).Available from URL: http://www .scielo.br/acb" 1998 2215 W2057126774.pdf 5 19 separator 0.9646902 ¶ 2215 2217 W2057126774.pdf 5 20 bibliography 0.9978233 "2. Haasler G. Ueber compensatorishe hypertrophie der lunge. Virchows Arch Pathol Anat Physiol. 1892;128:527-36." 2217 2331 W2057126774.pdf 5 21 separator 0.90065753 ¶ 2331 2333 W2057126774.pdf 5 22 bibliography 0.9978982 "3. Thurlbeck WM. Postpneumonectomy compensatory lung growth. Am Rev Resp Dis. 1983;128:965-7." 2333 2429 W2057126774.pdf 5 23 separator 0.7913389 ¶ 2429 2431 W2057126774.pdf 5 24 bibliography 0.9979198 "4. Addis T. Compensatory hypertrophy of the lung after unilateral pneumonectomy. J Exp Med. 1928;47:51-6." 2431 2539 W2057126774.pdf 5 25 separator 0.73324406 ¶ 2539 2541 W2057126774.pdf 5 26 bibliography 0.99793357 "5. Cohn R. Factors affecting the postnatal growth of the lung. Anat Rec. 1939;75:195-205." 2541 2633 W2057126774.pdf 5 27 separator 0.9371413 ¶ 2633 2635 W2057126774.pdf 5 28 bibliography 0.9976643 "6. Romanova LK. Regenerative hypertrophy of the lungs in rats after one-stage removal of the entire left lung andthe diaphragmatic lobe of the right lung. Bull Exp BiolMed. 1961;50:1192-7." 2635 2826 W2057126774.pdf 5 29 separator 0.95046103 ¶ 2826 2828 W2057126774.pdf 5 30 bibliography 0.9978557 "7. Sery Z, Kepri E, Obrucnik M. Morphometric analysis of late adaptation of the residual lung followingpneumonectomy in young and adult rabbits. J Thorac Cardiovasc Surg. 1969;57:549-57." 2828 3019 W2057126774.pdf 5 31 separator 0.94646966 ¶ 3019 3021 W2057126774.pdf 5 32 bibliography 0.99790955 "8. Buhain WJ, Brody JS. Compensatory growth of the lung following pneumonectomy. J Appl Physiol. 1973;35:898-902." 3021 3137 W2057126774.pdf 5 33 separator 0.9024924 ¶ 3137 3139 W2057126774.pdf 5 34 bibliography 0.9979398 "9. Tartter PI, Goss RJ. Compensatory pulmonary hypertrophy after incapacitation of one lung in the rat. JThorac Cardiovasc Surg. 1973;66:147-52." 3139 3286 W2057126774.pdf 5 35 separator 0.926628 ¶ 3286 3288 W2057126774.pdf 5 36 bibliography 0.997974 "10. Nattie EE, Wiley CW, Bartlett D Jr. Adaptive growth of the lung following pneumonectomy in rats. J ApplPhysiol. 1974;37:491-5." 3288 3421 W2057126774.pdf 5 37 separator 0.91862124 ¶ 3421 3423 W2057126774.pdf 5 38 bibliography 0.9979575 "11. Cowan MJ, Crystal RG. Lung growth after unilateral pneumonectomy quantitation of collagen synthesis andcontent. Am Rev Respir Dis. 1975;111:267-77." 3423 3578 W2057126774.pdf 5 39 separator 0.9208307 ¶ 3578 3580 W2057126774.pdf 5 40 bibliography 0.9978994 "12. Wandel G, Berger LC, Burri PH. Morphometric analysis of adult rat lung after bilobectomy. Am Rev Respir Dis.1983;128:968-72." 3580 3711 W2057126774.pdf 5 41 separator 0.9444886 ¶ 3711 3713 W2057126774.pdf 5 42 bibliography 0.9978373 "13. Cataneo AJM, Curi PR, Reibscheid SM. Alterações funcionais do aparelho respiratório pós-trilobectomiapulmonar: estudo experimental no rato. J Pneumol.1989;15:1-7." 3713 3882 W2057126774.pdf 5 43 separator 0.93887144 ¶ 3882 3884 W2057126774.pdf 5 44 bibliography 0.99792296 "14. Romanova LK, Leikina EM, Antipova KK. Nucleic acid synthesis and mitotic activity during development ofcompensatory hypertrophy of the lung in rats. Bull ExpBiol Med. 1967;63:303-6." 3884 4072 W2057126774.pdf 5 45 separator 0.91640544 ¶ 4072 4074 W2057126774.pdf 5 46 bibliography 0.99795854 "15. Brody JS, Burki SR, Kaplan N. Desoxyribonucleic acid synthesis in lung cells during compensatory lunggrowth after pneumonectomy. Am Rev Respir Dis.1978;117:307-16." 4074 4246 W2057126774.pdf 5 47 separator 0.9507085 ¶ 4246 4248 W2057126774.pdf 5 48 bibliography 0.997849 "16. Ruiz RL Jr, Curi PR, Cataneo AJM. Compensatory lung growth lung mass and protein content in trilobectomizedrats. Acta Cir Brás. 1996;11:127-32." 4248 4398 W2057126774.pdf 5 49 separator 0.94352806 ¶ 4398 4400 W2057126774.pdf 5 50 bibliography 0.99770147 "17. Cataneo AJM, Curi PR, Reibscheid SM. Alterações morfológicas do aparelho respiratório pós-trilobectomiapulmonar: estudo experimental no rato. J Pneumol.1988;14:121-6." 4400 4573 W2057126774.pdf 5 51 separator 0.96194077 ¶ 4573 4575 W2057126774.pdf 5 52 bibliography 0.99796003 "18. Langenburg SE, Blackbourne LH, Buchanan S A, Mauney, MC, Kim, SS, Sinclair, KN, Kern, JA, Teja, SS,Tribble, CG, Kron, I . Compensatory Growth of PorcineRight Lungs after Chronic Rejection of TransplantedLeft Lungs. Ann Thorac Surg. 1995;59:28-32." 4575 4828 W2057126774.pdf 5 53 separator 0.93453443 ¶ 4828 4830 W2057126774.pdf 5 54 bibliography 0.99790406 "19. Hsia CCW, Herazo LF, Fryder-Doffey F, Weibel R. Compensatory Lung Growth Occurs in Adult Dogs afterRight Pneumonectomy. J Clin Invest. 1994;94:405-12." 4830 4989 W2057126774.pdf 5 55 separator 0.96852493 ¶ 4989 4991 W2057126774.pdf 5 56 bibliography 0.9980126 "20.Crombleholme T M, Adzick NS, Hardy K, Longaker, MT, Bradley, SM, Duncan, BW, Verrier, ED, Harrison, M.R.Pulmonary lobar transplantation in neonatal Swine: Amodel for treatment of Congenital Diaphragmatic hernia.J Pediatr Surg. 1990;25:11-8." 4991 5237 W2057126774.pdf 5 57 separator 0.92213666 ¶ 5237 5239 W2057126774.pdf 5 58 bibliography 0.9979547 "21.Doerschuk CM., Sekhon HS. Pulmonary blood volume and edema in postpneumonectomy lung growth in rats.J Appl Physiol. 1990;69:1178-82." 5239 5378 W2057126774.pdf 5 59 separator 0.9537172 ¶ 5378 5380 W2057126774.pdf 5 60 bibliography 0.9979817 "22.Duebener LF, Takahashi Y , Wada H, Tschanz SA, Burri PH, Schäfers HJ. Do mature pulmonary lobes grow aftertransplantation into an immature recipient? Ann ThoracSurg. 1999;68:1165-70." 5380 5569 W2057126774.pdf 5 61 separator 0.93607605 ¶ 5569 5571 W2057126774.pdf 5 62 bibliography 0.99792224 "23.Georgopoulos D, Mink S N, Oppenheimer L. How is maximal expiratory flow reduced in canine postpneumonectomylung growth? J Appl Physiol. 1991;71:834-40." 5571 5729 W2057126774.pdf 5 63 separator 0.96407115 ¶ 5729 5731 W2057126774.pdf 5 64 bibliography 0.997918 "24.Ruiz RL Jr, Burini RC, Cataneo AJM. Compensatory lung growth: lung protein, DNA and RNA contents intrilobectomized rats. Acta Cir Bras. 1998;13:18-25." 5731 5887 W2057126774.pdf 5 0 paratext 0.9885381 Nanomaterials 2022 ,12, 2347 9 of 15 0 36 W4285010234.pdf 8 1 separator 0.88265425 ¶ 36 38 W4285010234.pdf 8 2 paratext 0.97180504 Nanomaterials 2021 , 11, x FOR PEER REVIEW 9 of 15 38 89 W4285010234.pdf 8 3 separator 0.9663095 ¶ ¶ 90 96 W4285010234.pdf 8 4 text 0.9982496 "portland cement systems. The use of inert grinding media such as corundum can be rec- ommended to avoid the contamination and pote ntial reactivity reduction of Class F fly ash." 97 280 W4285010234.pdf 8 5 separator 0.9157953 ¶ 281 283 W4285010234.pdf 8 6 text 0.9996003 "Based on XRD, the main cementitious comp onent of Class C fly ash capable of hy- dration and the formation of nano-seeds is C 3A, which is found in a crystalline phase at 32%, Figure 3b. Upon 3-hour hydration in the mill, the formation of a new phase of katoite (Ca 3Al2(SiO 4)3-x(OH) 4x, where x = 1.5–3) was detected, reducing the C 3A content to 11%. It can be observed that the C 3A phase was completely converted to katoite after 24 h of mill- ing. However, the follow-up activation for 24 h resulted in the contamination of a speci- men with iron at the level of up to 12%. Fu rthermore, extended milling results in the for- mation of considerable volumes of iron hydroxide phases such as lepidocrocite γ- FeO(OH) and goethite α-FeO(OH), the contribution of which to the hydration of portland cement systems is not clear. Therefore, it ca n be concluded that wet mechanical activation in a mill for up to 3 h results in the formation of potentially beneficial nano-seed phases derived from C 3A available in Class C fly ash, and th e overall process can be described as mechano-chemical activation." 283 1419 W4285010234.pdf 8 7 separator 0.98437214 ¶ ¶ 1420 1426 W4285010234.pdf 8 8 title 0.6071257 (a) 1426 1430 W4285010234.pdf 8 9 separator 0.97546136 ¶ 1431 1433 W4285010234.pdf 8 10 paratext 0.9802615 Nanomaterials 2021 , 11, x FOR PEER REVIEW 10 of 15 1433 1486 W4285010234.pdf 8 11 separator 0.9303049 ¶ ¶ 1488 1495 W4285010234.pdf 8 12 title 0.6654248 (b) 1495 1499 W4285010234.pdf 8 13 separator 0.9928932 ¶ 1500 1502 W4285010234.pdf 8 14 caption 0.99560606 "Figure 3. Transformation of (a) Class F fly ash (RF is a reference Class F fly ash; F3, F6, and F24 are Class F–based products activated for 3, 6, and 24 h, respectively) and (b) Class C fly ash (RC is a reference Class C fly ash; C3 and C24 are Class C products activated for 3 and 24 h, respectively) due to wet vibro -milling up to 24 h ." 1502 1854 W4285010234.pdf 8 15 separator 0.99371266 ¶ 1855 1857 W4285010234.pdf 8 16 title 0.9910845 3.2. Hydration Process 1857 1880 W4285010234.pdf 8 17 separator 0.99625146 ¶ 1882 1884 W4285010234.pdf 8 18 text 0.99965465 "Based on the heat of the hydration experiment, it was observed that the activation of fly ash in a vibro -mill considerably accelerates the hydration of cementitious systems with fly ash vs. reference mix (Figure 4 ). The best performance was reached by the composition with activate d Class F fly ash and nanosilica. Here, the formation of nano -seed products was not detected; thus, this effect is achieved mainly due to the contribution of ultrafine fly ash particles and nanosilica." 1884 2386 W4285010234.pdf 8 19 separator 0.93027127 ¶ ¶ 2388 2394 W4285010234.pdf 8 20 table 0.972021 "(a) 012345678910 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 Time, hoursHeat Flow, mW/g R R20C 20AC3 20AC-NS" 2394 2517 W4285010234.pdf 8 21 separator 0.9849427 ¶ 2517 2519 W4285010234.pdf 8 22 caption 0.99632084 "Figure 3. Transformation of ( a) Class F fly ash (RF is a reference Class F fly ash; F3, F6, and F24 are Class F–based products activated for 3, 6, and 24 h, respectively) and ( b) Class C fly ash (RC is a reference Class C fly ash; C3 and C24 are Class C products activated for 3 and 24 h, respectively) due to wet vibro-milling up to 24 h." 2519 2863 W4285010234.pdf 8 0 paratext 0.54054105 1554 0 4 W2074272762.pdf 0 1 title 0.9261939 COW’S MILK : A SUGGESTION.-BELFAST HEALTH COMMISSION. 4 58 W2074272762.pdf 0 2 separator 0.98840976 ¶ 58 60 W2074272762.pdf 0 3 text 0.999172 "of, the enormous amount of work done by others on immunity and of the work which probably lies at the root of these experiments-I mean that done on cytolytic processes." 60 233 W2074272762.pdf 0 4 separator 0.61923534 ¶ 233 235 W2074272762.pdf 0 5 text 0.9976907 "Mr. Walker in his reply confessed, in fact, to ignorance in regard to this." 235 313 W2074272762.pdf 0 6 separator 0.5735904 ¶ 313 315 W2074272762.pdf 0 7 text 0.99952173 "I hardly think it necessary to pick to pieces his criticism of my remarks, for he has so placed these, which were only published in brief abstract, out of the context, that I should have to write out what I said in full to make the position intelligible. To give an instance, surely work on immunisation "" is different from ""immunisation,"" as quoted by Mr. Walker as a positive fact I I must therefore be general. In the first place, I never said that the results of the work of others coincided in every particular with the results of Mr. Walker’s experiments-that would be too much to expect of any work-and I pointed out differences. In the second place I have a good imagination but I cannot recognise the ultimate difference between experiments on immunity and experiments on curative processes based on induced immunity. For Mr. Walker to say that experiments which "" deal with the immunisation of mice beforehand to tumours which were subsequently introduced ...... have no bearing upon the treatment of already existing and well-established tumours "" is-even if it were true, which it is not-to emphasise his ignorance of the nature of the process and the work done. Direct contradiction is given, if any were needed, by the experiments of Clowes and others on this very subject." 315 1645 W2074272762.pdf 0 8 separator 0.95839524 ¶ 1645 1647 W2074272762.pdf 0 9 text 0.99865794 "Then in regard to priority. In the historical portion of a paper by Bashford, Murray, and Cramer2 they state that Jensen (in 1901) "" observed the complete disappearance of tumours from mice that had been successfully inoculated. He added, however, that the results of attempts to cure mice of tumours have hitherto been uncertain.’ """ 1647 1991 W2074272762.pdf 0 10 separator 0.6301484 1991 1992 W2074272762.pdf 0 11 text 0.9965705 "¶ Again : I Borrel ...... recorded suggestive experiments directed to obtaining a polyvalent immune serum against human cancer."" Also : I Clowes ...... the animals in which spontaneous absorption had occurred were stated to possess a specific antibody in their serum which on injection into animals with transplanted tumours exerted a cnrati1)e effect"" "" (italics mine). And so on. There are several very important and interesting papers in the Third Scientific Report of the Imperial Cancer Research Fund dealing with the immunity established in rats to mouse tumours and the immunising effects of other tissues, including the work done with testis." 1992 2662 W2074272762.pdf 0 12 separator 0.92421955 ¶ 2662 2664 W2074272762.pdf 0 13 text 0.9986639 "Regarding Mr. Walker’s claim to "" cure "" mouse cancer with ""testis serum"" I have already spoken-and the less said about it the better !" 2664 2804 W2074272762.pdf 0 14 separator 0.9396459 ¶ 2805 2807 W2074272762.pdf 0 15 text 0.99577236 "In conclusion, I only wish there were a hopeful outlook for the experiments, but I think if Mr. Walker will make himself familiar with work on cytolysins generally (of which he confessed ignorance) he will, when he fully under- stands all they imply, be as doubtful as other workers have been who have considered the question of making a cytolytic serum for human cancer on these lines. All my criticism would have been avoided if Mr. Walker had acknowledged the work of others-whether he conscientiously considered that he was first in the field or not. I make no attack on Mr. Walker and unwillingly allow myself to say this much in answer to his attempt to clear himself. I shall not, therefore, discuss the matter further.-I am, Sir, yours faithfully, " 2807 3589 W2074272762.pdf 0 16 separator 0.6142599 ¶ 3589 3590 W2074272762.pdf 0 17 contact 0.711923 Liverpool, Nov. 14th, 1908. W. BLAIR BELL. 3590 3633 W2074272762.pdf 0 18 separator 0.47168696 3634 3635 W2074272762.pdf 0 19 contact 0.7461977 ¶ IW. BLAIR BELL. 3635 3652 W2074272762.pdf 0 20 separator 0.7911677 ¶ 3652 3654 W2074272762.pdf 0 21 title 0.7922737 THE NEUROTONE. 3654 3669 W2074272762.pdf 0 22 separator 0.8679648 ¶ 3669 3671 W2074272762.pdf 0 23 paratext 0.4465049 10 the Editor of THE 3671 3692 W2074272762.pdf 0 24 contact 0.37778556 LANCET 3692 3699 W2074272762.pdf 0 25 paratext 0.4022226 . 3699 3700 W2074272762.pdf 0 26 separator 0.988811 ¶ 3700 3702 W2074272762.pdf 0 27 text 0.99792325 "SIR,-May I state in your able journal that I am not the inventor of ""The Neurotone or Neurostone,"" as it is termed ; but during many years of research work in electricity I have found it a perfect appliance to accomplish the object I had in view. I am, Sir, yours faithfully," 3702 3986 W2074272762.pdf 0 28 separator 0.90966785 ¶ 3986 3988 W2074272762.pdf 0 29 contact 0.81957215 Ottawa, Nov. 4th, 1908. J. A. GRANT.J. A. GRANT. 3988 4037 W2074272762.pdf 0 30 separator 0.991861 ¶ 4037 4039 W2074272762.pdf 0 31 title 0.9828959 COW’S MILK: A SUGGESTION. 4039 4065 W2074272762.pdf 0 32 separator 0.942222 ¶ 4065 4067 W2074272762.pdf 0 33 title 0.72109497 To the Edatom of THE LANCET. 4067 4096 W2074272762.pdf 0 34 separator 0.9827961 ¶ 4096 4098 W2074272762.pdf 0 35 text 0.9989765 "SIR,-I should feel very much obliged if some of your readers who have patients unable to take ordinary cow’s milk would be so good as to try those patients with milk from cows which are not in calf. The milk that is supplied daily in this country is in 99 per cent. of cases obtained from cows" 4098 4400 W2074272762.pdf 0 36 separator 0.9867257 ¶ 4400 4402 W2074272762.pdf 0 37 bibliography 0.7897342 "2 The Natural and Induced Resistance of Mice to the Growth of Cancer, Proceedings of the Royal Society, B., vol. lxxvi., 1907.in" 4402 4533 W2074272762.pdf 0 38 text 0.986955 "calf. My experience so far has been that patients, espe- cially children, who were unable to digest the ordinary market commodity were when given milk obtained from cows not in calf able to take the latter and thrive on it. The difference between the two milks is considerable, as the drain of the embryonic calf must seriously interfere with the quality of the pregnant cow’s milk." 4533 4928 W2074272762.pdf 0 39 separator 0.9472262 ¶ 4928 4930 W2074272762.pdf 0 40 text 0.84721965 I am, Sir, yours faithfully, 4930 4959 W2074272762.pdf 0 41 contact 0.82334185 "¶ G. ARBOUR STEPHENS, Swansea, Nov. 9th, 1908.G. ARBOUR STEPHENS." 4959 5027 W2074272762.pdf 0 42 separator 0.9859417 ¶ 5027 5029 W2074272762.pdf 0 43 title 0.8501252 BELFAST HEALTH COMMISSION. 5029 5056 W2074272762.pdf 0 44 separator 0.74041486 ¶ 5056 5058 W2074272762.pdf 0 45 title 0.57891273 (FROM A CORRESPONDENT 5058 5080 W2074272762.pdf 0 46 paratext 0.5542304 .) 5080 5082 W2074272762.pdf 0 47 separator 0.9349065 ¶ 5082 5084 W2074272762.pdf 0 48 paratext 0.5259809 (Conclztded from p. 1483.) 5084 5111 W2074272762.pdf 0 49 separator 0.9798056 ¶ 5111 5113 W2074272762.pdf 0 50 text 0.99942994 "WITH reference to the deplorable state of affairs in Belfast pointed out by the recent Health Commission, that the corporation is without information as to the details of deaths occurring in its district beyond the mere numerical particulars obtained from the Registrar-General’s official publication-information without which no sanitary authority can adequately search for, or cope with, causes of disease and death-it is clear the excuse of the committee of the corporation, that it is the duty of the Local Govern- ment Board to promote the legislation suggested by the Health Commission in this direction, is mere fencing with the question. The corporation of Belfast should itself promote a Bill and ’’ the most effective and natural way of dealing with it (the question of vital statistics) is to follow the precedent of the English and Scottish Registration Acts, even if such a method involves fresh legislation; and we recommend that this should be done,"" says the Health Commission, and it further adds : ""In view of the importance of the information as to the details of deaths occurring within the city, we regret that the corporation did not fall in with the suggestion made to them in October, 1907, by the Local Government Board for Ireland, which, pending legislation, would have enabled them to get the information desired."" "" There can never be any proper public health administration in a city until the medical officer of health has trustworthy vital statistics, and, as the Health Commission reports, any health reforms attempted without such information must be in the nature of leaps in the dark. Imagine a city where, as the Health Commission says, the corporation does not know the causes of death among the children, where "" the corporation are com- pletely in the dark as to the places where deaths in the city are occurring, even from such important diseases as phthisis, tuberculosis, pneumonia, cancer, diarrhoea, or from diseases which may be due to industrial causes, to poverty, or to any of the other conditions which may be thought of as asso- ciated with modern town influences."" Dr. H. Whitaker, the former medical superintendent officer of health, often drew attention to the defects in his sources of information ; nay, more, Mr. H. W. Bailie, in his report just issued for 1907, says in reference to this matter, We are where we were a year ago. """ 5113 7584 W2074272762.pdf 0 51 separator 0.9576175 ¶ 7584 7586 W2074272762.pdf 0 52 text 0.9996375 "In the face of these facts, why does the corporation not promote a Bill itself and get this matter made right, which is the very foundation of public health, and put into its Health Bill all other matters-the control of the milk- supply, certain powers for sanitary administration (as advised by the Health Commission), the getting rid of the abomination of double tenement houses, the reorganisation of the antiquated system by which there is a medical super- intendent officer of health and 14 district medical officers of health, so as to make the medical superintendent officer of health the real head of his department, with personal control of everything pertaining to the public health, &c., so as to place Belfast on the level, in public health administra- tion, with any city in England or Scotland? When anyone suggests to the corporation of Belfast the trial of public health measures which have proved efficacious in other cities they always get the same answer, "" We have no powers,"" and the bogey of the Local Government Board is trotted ’out." 7586 8678 W2074272762.pdf 0 53 separator 0.9307442 ¶ 8678 8680 W2074272762.pdf 0 54 text 0.999484 "In reply, it may be said if you have not powers your duty is to get them. Sheffield and Bolton got special Acts passed to enable them to make pulmonary tuberculosis compulsorily notifiable, Manchester and Bristol went for special legisla- tion on the milk question, and Huddersfield was compli- mented by a Committee of the House of Commons for leading ¶" 8680 9045 W2074272762.pdf 0 0 text 0.9984517 "NMRspectroscopic investigations inCD2Cl2alreadyrevealvery similarspectraandthusverysimilarstructures.Thechemical shiftsoftheprotonsoftheferrocenebackbone(δ1HE4.3– 4.8ppm)andthebipyridylentity(δ1HE7.1–8.7ppm)areinthe sameregionastheonesofthemonofuntionalized 5-ferrocenyl- 2,2’-bipyridine, whichwerefirstdescribedbyCrowley.[12]" 0 336 W4200050903.pdf 2 1 separator 0.99383533 ¶ 336 338 W4200050903.pdf 2 2 text 0.99275875 "Figure2showsthemolecularstructuresoftheligands2A and2C.Incaseofcompound 2B,onlysmallcrystalscouldbe obtainedwherecrystalstructureanalysisconfirmedthecon-nectivity,butthedatasetwasofpoorquality.Thebondlengths andanglesprovesimilaritiestothemonofuntionalized 5- ferrocenyl-2,2’-bipyridine ligandsofCrowley.[12]Themolecular structuresoftheligandsareessentiallyunaffectedbythe additionalorganicsubstituentonthesecondCpring." 338 770 W4200050903.pdf 2 3 separator 0.9863491 ¶ 770 772 W4200050903.pdf 2 4 text 0.99890906 "Forthesetwocompounds, theferrocenebackbonesshow aneclipticarrangement. Thetwoarylsubstituents adopta stacked(syn)conformation andareparalleltoeachother,which islikelytheresultofbyπ-stacking.[13]Similareffectshavebeen observedbyCrowleyandco-workers.[6e,f]Wenoteinpassing thatinsolutiontheprotonsignalsassociatedwiththebipyridyl ringsof2A–2Careslightlyshiftedupfieldrelativetothoseof thesinglyfunctionalized compound 2D,[12]indicatingthatthe di-functionalized ferrocenederivativesmightalsoadopta stacked(syn)conformation insolution(FigureS26,Supporting Information).[6e,f]However,1H,1HNOESYand1H,19FHOESY measurements on2Aasrepresentative ofthenewlysynthe- sizedligandsgavenoindicationsforπinteractionsinsolution." 772 1508 W4200050903.pdf 2 5 separator 0.99011993 ¶ 1508 1510 W4200050903.pdf 2 6 text 0.99732846 "Thecomparison withothercompounds knownfromthe literatureshowsthatthebondlengthsandanglesaresimilar.[14]" 1510 1616 W4200050903.pdf 2 7 separator 0.8595286 ¶ 1616 1618 W4200050903.pdf 2 8 text 0.99916714 "Thebipyridineunitresemblesother2,2’-bipyridine derivatives, whichwasalreadyshownfortheanalogousmonofunctional- ized5-ferrocenyl-2,2’-bipyridine ligands[12]anditthusseems reasonabletoassumethatthecoordination behaviorissimilar." 1618 1851 W4200050903.pdf 2 9 separator 0.86824644 ¶ 1851 1853 W4200050903.pdf 2 10 text 0.99920094 "Toverifythis,theligandswerereactedwithdifferenttransition metalprecursorsofgroup8and10.Forreferencetothe electrochemical investigations plannedonthefreepro-ligands andalltheircomplexes,thecomplexesofthemonofunctional- ized5-ferrocenyl-2,2’-bipyridine oftheCrowleygroupwerealso synthesized.[12]Inthecurrentpaperwedenotethisliterature- knownligandas2Dinthefollowingdiscussion." 1853 2240 W4200050903.pdf 2 11 separator 0.9620887 ¶ 2240 2242 W4200050903.pdf 2 12 text 0.9989061 "Wethusfirstreactedthepro-ligands 2A–2Dwith[Pd- (cod)Cl2]inordertoobtainthesquare-planar Pd(II)complexes (Scheme4).Forthesakeofcompleteness andsubsequent electrochemical comparison, theliterature-known complex 3D[12]withligand2Dwasalsosynthesized. Ascopper(II)" 2242 2510 W4200050903.pdf 2 13 separator 0.99350655 ¶ 2510 2512 W4200050903.pdf 2 14 caption 0.99582 "Figure2.Molecularstructuresof2A(a)and2C(b).Hydrogenatomshave beenomittedforclarity.Selectedbondlengths[pm]andangles[°]:a)" 2512 2636 W4200050903.pdf 2 15 separator 0.86425114 ¶ 2636 2638 W4200050903.pdf 2 16 caption 0.9678118 C10 2638 2642 W4200050903.pdf 2 0 text 0.9880598 "pulse was converted to a voltage pulse through a 50 Ωimpedance and monitored with an oscilloscope. The time integral of the voltage pulsewas recorded." 0 152 W4387745025.pdf 5 1 separator 0.99384236 ¶ 152 154 W4387745025.pdf 5 2 text 0.99937385 "The BeO cathode surface had a cylindrical shape with a curvature radius of about 1 cm. As the THz beam, focused onto the cathode, had a relatively small waist radius of about 1.2 mm and a depth of focus ofseveral centimeters due to astigmatism (see Methods: THz beam andpulse characterization), the cathode surface curvature had only a slighteffect on the measured electron emission characteristics. The rough-ness of the BeO surface had a signi ficant effect on electron emission." 154 639 W4387745025.pdf 5 3 separator 0.9573599 ¶ 639 641 W4387745025.pdf 5 4 text 0.9924892 The characterization of the surface is described in more detail in Sup-plementary Information: Characterization of the BeO surface. 641 773 W4387745025.pdf 5 5 separator 0.9951985 ¶ 773 775 W4387745025.pdf 5 6 title 0.9921661 THz beam and pulse characterization 775 811 W4387745025.pdf 5 7 separator 0.99425125 ¶ 811 813 W4387745025.pdf 5 8 text 0.9994608 "The THz pulse energy was measured by a calibrated pyroelectric detector (Sensor- und Lasertechnik, THZ 20). A maximum energy of 2.34μJ was used at the BeO surface." 813 981 W4387745025.pdf 5 9 separator 0.9675325 ¶ 981 983 W4387745025.pdf 5 10 text 0.9992972 "THz beam pro files were recorded with a pyroelectric camera (Ophir, Pyrocam III) at different positions along the propagation axis.The beam waist radius in both the horizontal and the vertical direc-tions was about 1.2 mm (corresponding to 1 =e 2values of the peak intensity). Due to astigmatism, the distance between the horizontaland vertical foci was about 2 cm. This resulted in an extended focalregion and a reduced variation of the peak field strength across the BeO cathode surface." 983 1479 W4387745025.pdf 5 11 separator 0.9912417 ¶ 1479 1481 W4387745025.pdf 5 12 text 0.9993136 "THz waveforms were recorded by electro-optic sampling (EOS) in a 1-mm thick (110)-cut GaP crystal by using a small portion of the laser energy for the sampling pulses and balanced photodetection with alock-in ampli fier. The measured waveform is shown in Fig. 1c for the beam propagation coordinate corresponding to the BeO cathodeposition. The field strength and the single-cycle, nearly sine-like waveform changed only slightly over a propagation length of about 2cm. This ensured a reasonably good uniformity of the THz waveformacross the illuminated spot at the BeO cathode surface for all THzpolarization directions used in the experiment. The electric- field amplitude was obtained by combining the measured THz waveform,beam size, and pulse energy." 1481 2244 W4387745025.pdf 5 13 separator 0.99683994 ¶ 2244 2246 W4387745025.pdf 5 14 title 0.99370813 Calibration of the THz field polarity 2246 2283 W4387745025.pdf 5 15 separator 0.994171 ¶ 2283 2285 W4387745025.pdf 5 16 text 0.9891263 "The THz polarity was calibrated by comparison with a static (DC) field, utilizing an insulator LiNbO 3(LN) crystal for EOS (Fig. 2a). First, in the absence of the THz field, a high DC voltage (HV) of 4.4 kV and con- trolled polarity was applied to the LN crystal through the two elec-trodes near the top and bottom edges of the crystal. The opticalsampling pulse was sent through the crystal. When the HV was off, thetwo photodetectors were balanced and the output from the lock-inampli fier was zero. When an HV was applied with an upward-pointing electric field, the output from the lock-in ampli fier was negative. When the HV was reversed, the output changed sign. Figure 2bs h o w st h e " 2285 2984 W4387745025.pdf 5 17 caption 0.7277428 "¶ lock-in output of two such cycles with the HV manually switched on,off, and reversed. This output directly re flects the phase change of the probe" 2984 3133 W4387745025.pdf 5 18 text 0.7676619 passing through the LN crystal. 3133 3165 W4387745025.pdf 5 19 separator 0.99330336 ¶ 3165 3167 W4387745025.pdf 5 20 text 0.9993363 "During the next measurement steps, the HV was switched off and the THz pulse passed through the LN detector crystal. The opticalsampling pulse propagates much faster through the crystal than theTHz pulse and sweeps over the portion of the THz pulse that lies insidethe crystal 33,34(see Supplementary Information: Calibration of the THz field polarity). The THz electric- field waveform, directly comparable in polarity to the DC field, was obtained by taking the time derivative of the EOS trace originating from the input region of the crystal. Because the THz signal changed from negative to positive (Fig. 2c), a compar- ison with the HV bias (Fig. 2b) indicated that in the laboratory frame, the THz electric- field pointed upwards (downwards) in the leading (trailing) oscillation half-cycle. Based on this result and the geometryof the experimental setup, and taking into account the phase shiftupon re flection at the gold mirror, the THz electric- field polarity could easily be traced to the cathode surface. More details on field calibra- tion are given in Supplementary Information: Calibration of the THzfield polarity." 3167 4314 W4387745025.pdf 5 21 separator 0.9966373 ¶ 4314 4316 W4387745025.pdf 5 22 title 0.9937284 Calculation of the THz near field 4316 4349 W4387745025.pdf 5 23 separator 0.9935013 ¶ 4349 4351 W4387745025.pdf 5 24 text 0.9996912 "The THz near field at the cathode surface was calculated by the finite- element method. The measured surface topography data, obtained byatomic force microscopy (see Supplementary Information: Char-acterization of the BeO surface), were used to de fine the boundary conditions. For the simulations, two types of software were used:the FDTD 3D Electromagnetic Simulator (Lumerical, Inc.) for time-domain calculations and the COMSOL Multiphysics® (COMSOL AB)software for frequency-domain calculations. The latter was carried outat 0.3 THz and 0.5 THz frequencies. Both methods gave very similar field-enhancement values. The field enhancement was de fined as the ratio of the THz electric- field amplitude at the surface and the ampli- tude of the incoming field. Calculation results are shown in Fig. 4b, c." 4351 5160 W4387745025.pdf 5 25 separator 0.99527466 ¶ 5160 5162 W4387745025.pdf 5 26 title 0.959356 Data availability 5162 5180 W4387745025.pdf 5 27 separator 0.9886933 ¶ 5180 5182 W4387745025.pdf 5 28 text 0.968084 "Data underlying the res ults presented in this paper are available from the corresponding author upon request. The experimental data gen-erated in this study have been deposited in the Figshare databaseunder the accession code https://doi.org/10.6084/m9. figshare." 5182 5448 W4387745025.pdf 5 29 separator 0.7734158 ¶ 5448 5450 W4387745025.pdf 5 30 paratext 0.9481816 "24065715 35." 5450 5465 W4387745025.pdf 5 31 separator 0.8975537 ¶ 5465 5467 W4387745025.pdf 5 32 title 0.76070046 References 5467 5478 W4387745025.pdf 5 33 separator 0.9864239 ¶ 5478 5480 W4387745025.pdf 5 34 bibliography 0.9876133 "1. Keldysh, L. V. Ionization in the field of a strong electromagnetic wave. Sov. Phys. JETP 20,1 3 0 7 –1314 (1965). 2. Büttiker, M. & Landauer, R. Traversal time for tunneling. Phys. Rev. Lett. 49,1 7 3 9 –1742 (1982)." 5480 5705 W4387745025.pdf 5 35 separator 0.9335147 ¶ 5705 5707 W4387745025.pdf 5 36 bibliography 0.99768585 "3 . P u t n a m ,W .P . ,H o b b s ,R .G . ,K e a t h l e y ,P .D . ,B e r g g r e n ,K .K .& Kärtner, F. X. Optical- field-controlled photoemission from plas- monic nanoparticles. Nat. Phys. 13,3 3 5 –339 (2017)." 5707 5924 W4387745025.pdf 5 37 separator 0.9479853 ¶ 5924 5926 W4387745025.pdf 5 38 bibliography 0.99801105 "4. Farkas, G., Horváth, Z. G. & Kertész, I. In fluence of optical field emission on the nonlinear photoelectric effect induced by ultra-short laser pulses. Phys. Lett. A 39,2 3 1 –232 (1972)." 5926 6118 W4387745025.pdf 5 39 separator 0.95644236 ¶ 6118 6120 W4387745025.pdf 5 40 bibliography 0.99675715 "5 . T ó t h ,C . ,F a r k a s ,G .&V o d o p y a n o v ,K .L .L a s e r - i n d u c e de l e c t r o n emission from an Au surface irradiated by single picosecond pulsesatλ=2 . 9 4 μm. The intermediate region between multiphoton and tunneling effects. Appl. Phys. B 53, 221 –225 (1991)." 6120 6411 W4387745025.pdf 5 41 separator 0.9740942 ¶ 6411 6413 W4387745025.pdf 5 42 bibliography 0.9974769 "6 . B e c k e r ,W .e ta l .I n Advances in Atomic, Molecular, and Optical Physics . (eds Bederson, B., & Walther, H. Advances in atomic, molecular, and optical physics. Vol. 48, 35 –98 (Academic Press, 2002)." 6413 6629 W4387745025.pdf 5 43 separator 0.9209615 ¶ 6629 6631 W4387745025.pdf 5 44 bibliography 0.9978085 "7. Dombi, P. et al. Ultrafast strong- field photoemission from plas- monic nanoparticles. Nano Lett. 13,6 7 4 –678 (2013)." 6631 6755 W4387745025.pdf 5 45 separator 0.9179986 ¶ 6755 6757 W4387745025.pdf 5 46 bibliography 0.9978171 "8. Bormann, R., Gulde, M., Weismann, A., Yalunin, S. V. & Ropers, C. Tip-enhanced strong- field photoemission. P h y s .R e v .L e t t . 105, 147601 (2010)." 6757 6917 W4387745025.pdf 5 47 separator 0.8455316 ¶ 6917 6919 W4387745025.pdf 5 48 bibliography 0.9975428 "9. Teichmann, S. M. et al. Strong- field plasmonic photoemission in the mid-IR at <1 GW/cm 2intensity. Sci. Rep. 5,7 5 8 4( 2 0 1 5 ) ." 6919 7058 W4387745025.pdf 5 49 separator 0.7426996 ¶ 7058 7060 W4387745025.pdf 5 50 bibliography 0.9976486 "10. Dombi, P. et al. Observation of few-cycle, strong- field phenomena in surface plasmon fields. Opt. Express 18,2 4 2 0 6 –24212 (2010)." 7060 7199 W4387745025.pdf 5 51 separator 0.7616732 ¶ 7199 7201 W4387745025.pdf 5 52 bibliography 0.99768144 "11. Apolonski, A. et al. Observation of light-phase-sensitive photo- emission from a metal. Phys. Rev. Lett. 92,0 7 3 9 0 2( 2 0 0 4 ) ." 7201 7340 W4387745025.pdf 5 53 separator 0.7612972 ¶ 7340 7342 W4387745025.pdf 5 54 bibliography 0.99764466 "12. Dombi, P. et al. Direct measurement and analysis of the carrier- envelope phase in light pulses approaching the single-cycle regime. N. J. Phys. 6,3 9 –39 (2004)." 7342 7513 W4387745025.pdf 5 55 separator 0.8706179 ¶ 7513 7515 W4387745025.pdf 5 56 bibliography 0.9979309 "13. Paulus, G. G. et al. Silvestri, Absolute-phase phenomena in photo- ionization with few-cycle laser pulses. Nature 414,1 8 2 –184 (2001)." 7515 7658 W4387745025.pdf 5 57 separator 0.85030115 ¶ 7658 7660 W4387745025.pdf 5 58 bibliography 0.99787307 "14. Krausz, F. & Ivanov, M. Attosecond physics. Rev. Mod. Phys. 81, 163 –234 (2009)." 7660 7747 W4387745025.pdf 5 59 separator 0.9843966 ¶ 7747 7749 W4387745025.pdf 5 60 bibliography 0.95437163 "1 5 . I r v i n e ,S .E . ,D o m b i ,P . ,F a r k a s ,G .&E l e z z a b i ,A .Y .I n fluence of the carrier-envelope phase of few-cycle pulses on ponderomotiveArticle https://doi.org/10.1038/s41467-023-4231" 7749 7959 W4387745025.pdf 5 61 paratext 0.5813983 6-0 7959 7962 W4387745025.pdf 5 62 separator 0.65340906 ¶ 7962 7964 W4387745025.pdf 5 63 paratext 0.98014015 Nature Communications | (2023) 14:6596 6 7964 8013 W4387745025.pdf 5 0 text 0.99773574 "¶ assessed by a few teachers , the e fficient peer evaluation mechanism need to be design ed. A learner's home work is randomly assigned to another learner evaluation , and the process should be justice [ 8]. This r equireme nt should be provided from M OOC platform, and to achieve thousands of learners to complete the evaluation function of peer review." 1 378 W2775596896.pdf 6 1 separator 0.99645925 ¶ 380 382 W2775596896.pdf 6 2 title 0.9913382 3 Future research es 382 403 W2775596896.pdf 6 3 separator 0.9939621 ¶ 404 406 W2775596896.pdf 6 4 text 0.99924755 "With the development o n educational information, on the current background of big data, mobile cloud and so on , the research on design ing of instructional software needs to keep up with the pace o n new technology in the future." 406 647 W2775596896.pdf 6 5 separator 0.99648803 ¶ 649 651 W2775596896.pdf 6 6 title 0.9937119 3.1 Design of teaching platform for SPOC 651 692 W2775596896.pdf 6 7 separator 0.9935857 ¶ 694 696 W2775596896.pdf 6 8 text 0.99959636 "SPOC(Small Private Online Course) is the new development on web learning which is derivative of MOOC.SPOC is also the most important way f or learning in Post -MOOC Era[9] . For small -scale learning crowd, focusing on campus localization, and to promote hybrid learning are the characters on SPOC. The teaching platform for SPOC can be a simplified de sign of the existing MOOC platforms, and is only applied on micro -curriculum construction. Colleges and universities can also design teaching platforms for hybrid teaching process which is based on SPOC concept according to the actual teaching environment." 696 1338 W2775596896.pdf 6 9 separator 0.99667764 ¶ 1340 1342 W2775596896.pdf 6 10 title 0.9931209 3.2 Design of resources for m obile learning 1342 1388 W2775596896.pdf 6 11 separator 0.9896042 ¶ 1390 1392 W2775596896.pdf 6 12 text 0.9995949 "With the popularity of 4G mobile networks, the learning by the using of mobile devices and wireless network has become the main learning methods. Mobile learning resources have the characters o n simple interface , small and accurate of information content, and the design of interactivity, compatibility, applicability, and real-time on data transmission for various mobile client platforms (Android /Mac OS/Symbian) will be the trend o n teaching software design ing in the future [ 10]." 1392 1907 W2775596896.pdf 6 13 separator 0.9969207 ¶ 1908 1910 W2775596896.pdf 6 14 title 0.99303603 "3.3 Intelligen ce on design ing of instruction software" 1910 1970 W2775596896.pdf 6 15 separator 0.99171 ¶ 1971 1973 W2775596896.pdf 6 16 text 0.9994052 "With the development of teaching theory and artificial intelligence technology, especially the emergence of constructivism and Agent, learning activities have become a process of acquir ing knowledge, including dialogue, situation, collaboration and meaning construction, and the direction of development on learning is to explore, cooperate and exchange on society." 1973 2353 W2775596896.pdf 6 17 separator 0.7882868 ¶ 2354 2356 W2775596896.pdf 6 18 text 0.99826497 "The design of I ntelligent Tutoring System [11], Adaptive Hypermedia System(A HS), I nteractive Learning Environment, Distributed Intelligent Learning System, and Educational Semantic Web will be the mainly direction s for intelligent design ing of instruction software in the future." 2356 2657 W2775596896.pdf 6 19 separator 0.9949263 ¶ 2660 2662 W2775596896.pdf 6 20 title 0.9138292 4 Acknowledgments 2662 2680 W2775596896.pdf 6 21 text 0.964916 "Author acknowledge s financial sup port from the projects on teaching team of ""Software Engineering course "" of Anhui SanLian University ( No. 15zlgc029) and ""Massive Open Online Course on Software Engineering "" of Anhui Province ( No. 2015mooc104). Here, I would like to express my heartfelt gr atitude to other colleagues from the both projects ." 2681 3051 W2775596896.pdf 6 22 separator 0.99493515 ¶ 3052 3054 W2775596896.pdf 6 23 title 0.87917775 References 3054 3065 W2775596896.pdf 6 24 separator 0.9850491 ¶ 3067 3069 W2775596896.pdf 6 25 bibliography 0.9962868 "1. Yu Shengquan, The Handbook of Instruc tional Software Design, Beijing Tsinghua University Press, 2011." 3069 3184 W2775596896.pdf 6 26 separator 0.72633815 ¶ 3186 3188 W2775596896.pdf 6 27 bibliography 0.99766743 "2. Li Wenhao, Zheng Yan, Instructional Simulation: The New Approach in Integrating Technology in the Curriculum , Journal of modern educational technology, 2009, 16(4) :9-12." 3188 3376 W2775596896.pdf 6 28 separator 0.9212153 ¶ 3379 3381 W2775596896.pdf 6 29 bibliography 0.99756134 "3. Yin Rui, Action Research on the Web -based and Problem -based Coope rative Learning Activity Design , Journal of modern educational technology, 2005,15(4) :34-39." 3381 3558 W2775596896.pdf 6 30 separator 0.9502331 ¶ 3561 3563 W2775596896.pdf 6 31 bibliography 0.99779016 "4. Wang Guangxin , Dong Fei, Summary of Educational Games Basic Structure and Character , Journal of China Educational Technology , 2009, (7) :77-80." 3563 3720 W2775596896.pdf 6 32 separator 0.905169 ¶ 3721 3723 W2775596896.pdf 6 33 bibliography 0.99755985 "5. Wu Fati, The Principle of Objectives -Driven E - Learning Course Design , Journal of China Educational Technology , 2006,(1) :17-20." 3723 3866 W2775596896.pdf 6 34 separator 0.9406787 ¶ 3870 3872 W2775596896.pdf 6 35 bibliography 0.99790686 "6. Cheng Zhu, LI Guilin, LIU Hai tao,The Develop ments of Chinese MOOC Platforms ,Journal of Higher Education Research, 20 14,37(2) :15-16." 3872 4021 W2775596896.pdf 6 36 separator 0.91692924 ¶ 4022 4024 W2775596896.pdf 6 37 bibliography 0.99779636 "7. Wu Jinhui, Contrastive Analysis on Main MOOC Platfor ms in China , Journal of Library Work in Colleges and Universities ,2015, 35(1) :11-14." 4024 4175 W2775596896.pdf 6 38 separator 0.96245635 ¶ 4176 4178 W2775596896.pdf 6 39 bibliography 0.9976253 "8. Huang Ming, Liang Xu,Gu Xiaolin, Mass O pen Online Course -MOOC Overview ,Beijing: Publishing House of Electronics Industry , 201 5." 4178 4323 W2775596896.pdf 6 40 separator 0.8985957 ¶ 4324 4326 W2775596896.pdf 6 41 bibliography 0.9977421 "9. He Bin, CaoYang, SPOC: MOOC -based I nnovation of Teaching Processes , Journal of China Educational Technology , 2015,(3) :22-27." 4326 4468 W2775596896.pdf 6 42 separator 0.92882454 ¶ 4472 4474 W2775596896.pdf 6 43 bibliography 0.9978916 "10. Li Lei,Li Xiaoli, Research on M -learning Resource Design Based on IOS Handheld Device , Journal of China Educational Technology , 2014 ,(12) :93-97." 4474 4637 W2775596896.pdf 6 44 separator 0.9616777 ¶ 4641 4643 W2775596896.pdf 6 45 bibliography 0.9962932 "11. Xu Gaopan, Zeng Wenhua, Huang Cuilan, Research on intelligent tutoring system, Journa l of Application Research of Computers, 2009, 26(11) : " 4643 4801 W2775596896.pdf 6 46 separator 0.49802497 ¶ 4801 4802 W2775596896.pdf 6 47 bibliography 0.9087184 4019- 4802 4808 W2775596896.pdf 6 48 paratext 0.64343554 4808 4809 W2775596896.pdf 6 49 bibliography 0.5056967 4022 4809 4813 W2775596896.pdf 6 50 paratext 0.837267 4813 4814 W2775596896.pdf 6 51 bibliography 0.49163687 . 4814 4815 W2775596896.pdf 6 52 paratext 0.96677554 "MATEC Web of Conferences 139, 00009 (2017) DOI: 10.1051/matecconf/201713900009 ICMITE 2017" 4815 4909 W2775596896.pdf 6 53 separator 0.53080404 ¶ 4909 4911 W2775596896.pdf 6 54 paratext 0.97729367 7 4911 4913 W2775596896.pdf 6 0 paratext 0.99064165 Geriatrics 2024 ,9, 35 3 of 17 0 30 W4392563304.pdf 2 1 separator 0.98248684 ¶ 30 32 W4392563304.pdf 2 2 title 0.9890683 Ophiocephalus striatus extract on the IGF-1 and IL-6 levels in older adults with sarcopenia. 32 125 W4392563304.pdf 2 3 separator 0.9885796 ¶ 125 127 W4392563304.pdf 2 4 text 0.97081774 "The results of this study are expected to provide valuable insights for clinicians in managing elderly patients with sarcopenia." 127 258 W4392563304.pdf 2 5 separator 0.99667 ¶ 258 260 W4392563304.pdf 2 6 title 0.99283105 2. Materials and Methods 260 285 W4392563304.pdf 2 7 separator 0.9956793 ¶ 285 287 W4392563304.pdf 2 8 text 0.99927574 "This study was a double-blind randomized controlled trial aimed at determining the effects of Ophiocephalus striatus extract on the IGF-1 and IL-6 levels in older adults with sarcopenia. The study was conducted at the Geriatric Clinic of RSUP Dr. Mohammad Hoesin, Palembang. Ethical clearance was obtained from the Research Ethics Commission (No. DP .04.03/D.XVIII.6.11/ETIK/36/2023). This study spanned from March 2023 to August 2023. The target population consisted of elderly patients aged 60 years and above with sarcopenia who sought treatment at the Geriatric Clinic of RSUP Dr. Mohammad Hoesin, Palembang. This RCT was registered under trial registration number NCT05869383." 287 983 W4392563304.pdf 2 9 separator 0.9974619 ¶ 983 985 W4392563304.pdf 2 10 title 0.99191266 2.1. Inclusion Criteria 985 1009 W4392563304.pdf 2 11 separator 0.99435174 ¶ 1009 1011 W4392563304.pdf 2 12 text 0.9994892 "Older adults ( ≥60 years old, in line with the Indonesian Ministry of Health Regula- tion) with sarcopenia were diagnosed using AWGS criteria, which include low muscle mass (estimated appendicular skeletal muscle index BIA cut-off of <7.0 kg/m2for males, <5.7 kg/m2for females), low muscle strength (measured using a handgrip dynamometer: <28 kg for males, <18 kg for females), and low physical performance (assessed using the 6 m walk test: <1 m/s)." 1011 1472 W4392563304.pdf 2 13 separator 0.99719095 ¶ 1472 1474 W4392563304.pdf 2 14 title 0.9899254 2.2. Exclusion Criteria 1474 1498 W4392563304.pdf 2 15 separator 0.9936203 ¶ 1498 1500 W4392563304.pdf 2 16 text 0.99935794 "Patients with severe chronic liver disease or elevated SGPT levels > 3 times the up- per limit of normal, impaired kidney function with an estimated glomerular filtration rate < 30 mL/min without hemodialysis, acute disease phase (e.g., acute infection, acute arthritis, acute stroke, trauma), malignancy, depression according to the Geriatric Depres- sion Scale (score > 10), history of hypersensitivity to Ophiocephalus striatus , or that refused to participate in the study were excluded from this study." 1500 2018 W4392563304.pdf 2 17 separator 0.9968996 ¶ 2018 2020 W4392563304.pdf 2 18 title 0.9900808 2.3. Drop-Out Criteria 2020 2043 W4392563304.pdf 2 19 separator 0.9934443 ¶ 2043 2045 W4392563304.pdf 2 20 text 0.9995249 "Subjects were considered dropped if subjects died before day 14, were lost to follow- up, experienced severe adverse effects, developed acute conditions during the follow-up period, or withdrew from participation before the completion of the study." 2045 2298 W4392563304.pdf 2 21 separator 0.99712706 ¶ 2298 2300 W4392563304.pdf 2 22 title 0.99100065 2.4. Data Collection 2300 2321 W4392563304.pdf 2 23 separator 0.9958468 ¶ 2321 2323 W4392563304.pdf 2 24 text 0.9993895 "The data collection included sociodemographic information, comorbidities based on patient history and medical records, physical examinations, anthropometric measurements (height, weight, upper arm and calf circumferences), nutrition assessment (using the Mini Nutritional Assessment and 3-day food records), a functional status assessment (using the Barthel Activities of Daily Living score), mental status assessment (using the Geriatric Depression Scale), cognitive status assessment (using the Abbreviated Mental Test), sarcopenia screening (using the SARC-F questionnaire and calf circumference), a handgrip strength assessment (using the Jamar Hydraulic Hand Dynamometer Model J00105), a 6 m walk speed assessment, a muscle mass assessment (using Bio Impedance Analysis TANITA BC-545N), and laboratory tests for IGF-1 and IL-6. The selected BIA model was chosen due to its widespread use in clinical settings across Indonesia, and the BIA is supported by current guidelines, while the DXA is not available in Palembang, and Indonesia has only one, located in Jakarta." 2323 3420 W4392563304.pdf 2 25 separator 0.96757674 ¶ 3420 3422 W4392563304.pdf 2 26 text 0.9996319 "In this study, the type of sarcopenia under investigation was not limited. Instead, subjects who met the criteria for sarcopenia as defined by the Asian Working Group for Sarcopenia (AWGS) in 2019 and who also fulfilled all the inclusion criteria specified for the study were included. By adhering to these inclusion criteria and utilizing the AWGS guidelines for sarcopenia diagnosis, a standardized approach for participant selection was" 3422 3870 W4392563304.pdf 2 0 paratext 0.97249 ¶ © Mehran University of Engineering and Technology 2022 56 1 79 W4290000745.pdf 2 1 text 0.9949225 "from a given point to search for the final solution in a possible region. This method was firstly proposed in 1984 [23] and has since been investigated in several studies [24]. This method has been used in various fields of power system operation such as economic load dispatch security -constrained optimal power flow, assessment of power system load -ability, and loss reduction [25]. This method is often used to solve linear optimization problems such as transmission expansion planning [26]. The main weakness of the internal point method is when the active constraints prevent the point from reaching the zero point or the acceptable boundary." 79 767 W4290000745.pdf 2 2 separator 0.9193966 ¶ 768 770 W4290000745.pdf 2 3 text 0.9994739 "Therefore, the great challenge in applying this method to solving the optimal power flow problem is to introduce a robust convergence approach to show the current limitations to prevent inefficiency. To deal with this problem in [27], some guidelines were discussed." 770 1049 W4290000745.pdf 2 4 separator 0.9397759 ¶ 1050 1052 W4290000745.pdf 2 5 text 0.9993523 "The penalty function method is used to solve the nonlinear optimization problem in which a quadratic approximation is used to solve the internal point method problem [28]." 1052 1237 W4290000745.pdf 2 6 separator 0.8925892 ¶ 1239 1241 W4290000745.pdf 2 7 text 0.9995 "Probability theory is used to indicate the uncertain ty of optimal power flow [29]. A fuzzy -based optimization approach is proposed to schedule the generation in power systems considering various uncertainties [30]." 1241 1471 W4290000745.pdf 2 8 separator 0.9397479 ¶ 1472 1474 W4290000745.pdf 2 9 text 0.9903342 "Addressed the different types of probabilistic uncertainties in load -flow studies in the mode rn power system [31]. The point estimation method has been expanded using random variables with an arbitrary distribution in the probability optimal power flow [32]." 1474 1752 W4290000745.pdf 2 10 separator 0.8031746 ¶ 1753 1755 W4290000745.pdf 2 11 text 0.99952966 "Presented a method for combining (1+2m) to investigate the impacts of different random inp uts concluding spatial and temporal variables [33]. Also, a modified PEM is analyzed POPF problem considering the correlation between sole, wind as well as the demanded loads [9, 21]." 1755 2045 W4290000745.pdf 2 12 separator 0.9618002 ¶ 2047 2049 W4290000745.pdf 2 13 text 0.9996878 "The OPF problem has been studied in a multi - objective optimization frame work [34]. Also, investigating this complex problem in the stochastic condition in the presence of random variables arising from wind and solar energy resources and their correlation by using the probability density functions is of great importance. The au thors in [35] have addressed this concept by applying the MCS method. Two MCS methods are proposed, along with the point estimation method [36]." 2049 2552 W4290000745.pdf 2 14 separator 0.97022426 ¶ 2554 2556 W4290000745.pdf 2 15 text 0.9997043 "The MCS method is usually a basic framework for POPF since it uses the real nonlinear power flow equations, and it is simple to expand. The answers to this method are used as a benchmark. MCS is among the widely applied numerical methods for POPF. Analytical solutions provide another option for solving POPF using probability densities. A PEM is a solution option fo r a probabilistic problem that operates with random variables [37]. PEM is considered a state -of-the-art method for solving OPF problems with accuracy and efficiency. Rosenblueth modified the PEM as 2 m [17]." 2556 3164 W4290000745.pdf 2 16 separator 0.9847542 ¶ 3166 3168 W4290000745.pdf 2 17 text 0.99955636 "Probabilistic methods, including the MCS Method and the PEM, have been used [38]. By using the MCS Method, we can achieve the exact voltage and power flow of branches. PEM is widely used to distribute the probability of the optimal probability flow problem, which can be used to calculate the significan t statistical results of a deterministic optimal flow [37]." 3168 3551 W4290000745.pdf 2 18 separator 0.9759549 ¶ 3553 3555 W4290000745.pdf 2 19 text 0.999655 "PEM for analyzing the statistical moments of a random value as a function of “ m input random variables” is proposed . The load is modeled as a random variable, and two individual cases of PEM concl uding 2m and 2 m+1 concentration schemes were considered [39]. In the 2 m scheme, only the skewness is considered , but in the 2 m+1 scheme, both skewness and kurtosis are mentioned in PDF. As the value of a random variable change based on predetermined distri bution, the expected values for voltage of the buses and line loading are determined. Also, the results of deterministic PLF are entirely compared with the obtained results applying 2m and 2 m+1 scheme ." 3555 4263 W4290000745.pdf 2 20 separator 0.9831853 ¶ 4264 4266 W4290000745.pdf 2 21 text 0.9995468 "We have modeled the wind speed as a Weibull distributi on using actual data and normal distributions for modeling the demanded loads [40]. The PEMs are compared with MCS results. As it was reported in this reference, the PEMs reach acceptable results in acceptable calculation time. However, in some conditions, PEMs may give inaccurate results." 4266 4633 W4290000745.pdf 2 22 separator 0.9780885 ¶ 4635 4637 W4290000745.pdf 2 23 text 0.9989942 "Combined Zhao's PEM with Nataf transformation and applied the combined method to solve the correlated PLF [9]. As it was stated in that reference, the mentioned technique can quickly deal with correlated input random variables in non -normal and normal Probability Density Functions (PDFs)." 4637 4945 W4290000745.pdf 2 24 separator 0.9845766 ¶ 4947 4949 W4290000745.pdf 2 25 text 0.9991028 "Applied power system graph in which a novel probabilistic strategy for generating all probable islanding solutions are mentioned , and they are reduced using different evaluating static an d dynamic constraints they are reduced [41]. The presented technique considers the relevant uncertainties to the wind farm and demanded loads and analyzed the steady - state stability of all partitions in each possible solution." 4949 5390 W4290000745.pdf 2 0 paratext 0.9775121 35 Page 10 of 71 Partial Differential Equations and Applications (2023) 4 :35 0 77 W3081631753.pdf 9 1 separator 0.99471354 ¶ 77 79 W3081631753.pdf 9 2 text 0.992556 "Furthermore, ( 1.14 )a n d( 2.1) imply that X(t(s,ξ) , x(s,ξ) )=X(0,ξ)=g(ξ),f o rs o m e strictly increasing function g∈C1(R). Differentiation, combined with ( 2.1)a n d( 2.3) yields" 79 264 W3081631753.pdf 9 3 separator 0.91653395 ¶ 264 266 W3081631753.pdf 9 4 math 0.9254777 "Xt=g/prime(ξ)ξ t=−g/prime(ξ)xs xξand Xx=g/prime(ξ)ξ x=g/prime(ξ)1 xξ, (2.4) " 266 347 W3081631753.pdf 9 5 separator 0.4035977 ¶ 347 348 W3081631753.pdf 9 6 text 0.755571 which implies 0 " 98 243 W4367173281.pdf 15 6 separator 0.95932484 ¶ 244 246 W4367173281.pdf 15 7 paratext 0.7659266 16 246 249 W4367173281.pdf 15 8 text 0.96402586 "Para tanto, a Pedagogia deve continuar o seu percurso de construir a humanidade no homem, elevar a uma cultura que conecta o íntimo com o universal, entendendo que o campo pedagógico é impactado pelas políticas públicas relativa aos sistemas escolares, nos “cumpre o dever de fazer com que a pedagogia não ceda as artimanhas do capitalismo" 249 599 W4367173281.pdf 15 9 bibliography 0.98108745 ” (FREIRE, 1996 , p. 82). 599 624 W4367173281.pdf 15 10 separator 0.9911043 ¶ 626 628 W4367173281.pdf 15 11 text 0.99896586 "Nesse momento do país com a Resolução CNE 02/2019 se reverbera no cenário educacional uma lógica ameaçadora que institui a pedagogia de competências enquanto “salvadora” dos problemas educacionais, se evidencia uma estreita relação da educação à teoria do capital humano, do sujeito econômico e empreendedor; culminando no esvaziamento do princípio da humanização, da criticidade, dos processos de interculturalidade e na interrelação existente entre escola e democracia." 628 1112 W4367173281.pdf 15 12 separator 0.9775548 ¶ 1114 1116 W4367173281.pdf 15 13 text 0.9873696 Assim como assinalam Pimenta, Pinto e Severo (2020, p . 14): 1116 1177 W4367173281.pdf 15 14 separator 0.91780007 ¶ 1178 1180 W4367173281.pdf 15 15 text 0.99888146 "Na óptica do compromisso com a democracia, a educação é concebida como prática social crítica e transformadora. Diante do quadro problemático que se expõe com o avanço da ação mercadológica no campo das polí ticas educacionais e, mais especificamente, na rentabilização da formação docente por conglomerados financeiros próprios das ideologias neoliberais que operam nas estruturas do Estado, é preciso assumir a necessidade de situar propostas de org anização curricular do curso de Pedagogia nessa concepção. Formar profissionais no curso de Pedagogia." 1180 1779 W4367173281.pdf 15 16 separator 0.9688118 ¶ 1781 1783 W4367173281.pdf 15 17 text 0.9992692 "Portanto, não cabe pensar a Pedagogia distanciada de um contexto histórico e desvinculadas da políticas vigente; ou engessada a uma identificação restri tiva vinculada a condução de crianças, pois, ela (a pedagogia) se nutre de uma dinâmica e conforme explicita Franco (2021, p. 727):" 1783 2075 W4367173281.pdf 15 18 separator 0.97519207 ¶ 2077 2079 W4367173281.pdf 15 19 text 0.99948376 "A Pedagogia como prática da educação e da liberdade está continuamente mergulhada em relações desiguais de poder, o que, en tre outras coisas, lhe confere seu inexorável papel político e ético. Assim, como se sabe, sua prática nunca será neutra e nem tão explícita. Desta forma, impõe -se a leitura crítica de sua prática para identificar o lugar da construção de sua intencionalid ade: a favor dos que são oprimidos por lógicas de dominação; ou a favor dos dominantes que pretendem assegurar seus privilégios e seus sistemas de opressão. Suas práticas estruturam -se para criar possibilidades de resistências às opressões constituídas ou essas práticas se organizam para a manutenção dos mecanismos que perpetuam as desigualdades?" 2080 2836 W4367173281.pdf 15 20 separator 0.98350966 ¶ 2838 2840 W4367173281.pdf 15 21 text 0.9990011 "Nós, pesquisadores implicados com a Pedagogia, precisamos continuar a manifestação a favor da Pedagogia, pois ela é legítima e necessária na construção de uma soci edade mais justa, coadunando com a defesa de Houssaye (2004, p. 7 -8):" 2840 3081 W4367173281.pdf 15 22 separator 0.95280695 ¶ 3082 3084 W4367173281.pdf 15 23 text 0.996269 "a pedagogia é legítima; a pedagogia é um saber legítimo; a pedagogia produz saberes legítimos e historicamente legitimados; a pedagogia produz saberes específicos; a formação pedagógic a é legítima; a formação pedagógica é específica; a formação pedagógica deve ser construída em torno desses saberes legítimos e específicos; a formação pedagógica deve ser construída por pedagogos; os saberes pedagógicos se" 3084 3510 W4367173281.pdf 15 0 paratext 0.54208106 CORRECTION 0 10 W4237890918.pdf 0 1 separator 0.97059155 ¶ 10 12 W4237890918.pdf 0 2 title 0.9126305 "Correction: Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A SystematicReview" 12 104 W4237890918.pdf 0 3 separator 0.44703746 ¶ 104 106 W4237890918.pdf 0 4 title 0.7812076 ThePLOS ONE Staff 106 124 W4237890918.pdf 0 5 separator 0.98798215 ¶ 124 126 W4237890918.pdf 0 6 text 0.8576392 "There are errors in the author affiliations. The publisher apologizes for the error. The affilia- tions should appear as shown here:" 126 261 W4237890918.pdf 0 7 separator 0.9898162 ¶ 261 263 W4237890918.pdf 0 8 contact 0.9845861 Vikki G. Nolan1, Kerri A. Nottage2, Elliott W. Cole1, Jane S. Hankins2, James G. Gurney1,3 263 354 W4237890918.pdf 0 9 separator 0.80175954 ¶ 354 356 W4237890918.pdf 0 10 contact 0.9876637 "1 Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, TN, USA, 2 Department of Hematology, St. JudeChildren ’s Research Hospital, Memphis, TN, USA, 3 Department of Epidemiology and Cancer Control, St. Jude Children ’s Research Hospital, Memphis, TN, USA." 356 686 W4237890918.pdf 0 11 separator 0.9479021 ¶ 686 688 W4237890918.pdf 0 12 paratext 0.78701735 Reference 688 698 W4237890918.pdf 0 13 separator 0.9780555 ¶ 698 700 W4237890918.pdf 0 14 bibliography 0.97115993 "1. Nolan VG, Nottage KA, Cole EW, Hankins JS, Gurney JG (2015) Prevalence of Vitamin D Deficiency in Sickle Cell Disease: A Systematic Review. PLoS ONE 10(3): e0119908. doi: 10.1371/journal.pone. 0119908 PMID: 25734582" 700 923 W4237890918.pdf 0 15 separator 0.7622745 ¶ 923 925 W4237890918.pdf 0 16 paratext 0.9630647 "PLOS ONE | DOI:10.1371/journal.pone.0128853 May 18, 2015 1/1 OPEN ACCESS" 925 1000 W4237890918.pdf 0 17 separator 0.87249446 ¶ 1000 1002 W4237890918.pdf 0 18 paratext 0.92560995 "Citation: ThePLOS ONE Staff (2015) Correction: Prevalence of Vitamin D Deficiency in Sickle CellDisease: A Systematic Review. PLoS ONE 10(5):e0128853. doi:10.1371/journal.pone.0128853 Published: May 18, 2015" 1002 1214 W4237890918.pdf 0 19 separator 0.7502122 ¶ 1214 1216 W4237890918.pdf 0 20 paratext 0.9528633 "Copyright: © 2015 The PLOS ONE Staff. This is an open access article distributed under the terms of theCreative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited." 1216 1492 W4237890918.pdf 0 0 text 0.65638673 18 0 4 W4283373401.pdf 17 1 separator 0.69976085 ¶ 4 5 W4283373401.pdf 17 2 text 0.9979402 "(HRLT). The HRLT dataset shows an overall high correlation with the observation s from 357 meteorological stations for daily maximum and minimum temperature s (R2 was 0.98 and 0.99, 358 respectively; Cor were both 0.99; NSE was 0.98 and 0.99, respectively) and the error s were smaller 359 (MAE was 1.07 °C and 1.08 °C, respectively; RMSE was 1.62 °C and 1.53 °C, respectively). 360" 6 399 W4283373401.pdf 17 3 separator 0.65748346 ¶ 400 402 W4283373401.pdf 17 4 text 0.99842465 "Although the HRLT dataset showed that the daily precipita tion accuracy was lower than the daily 361 temperature accuracy (R2, Cor, NSE, MAE , and RMSE were 0.71, 0.84, 0.70, 1.30 mm, and 4.78 362 mm, respectively), the daily precipitation data in the HRLT dataset were more accurate and had a 363 finer spatial resolution comp ared to the other t hree existing datasets (CMFD , CLDAS and 364 ISIMIP3a ). Furthe rmore , the accuracies for daily maximum and minimum temperature s and 365 precipitation were lower in the southwestern part of China, probably because of the complex 366 topography in that area compared to other areas. Calculation and interpolation by subregions may 367 solve this problem in future studies . The use of satellite data as an input covariate in future studies 368 will further improve the accuracy of the HRLT dataset, especially for precipitation. The HRLT 369 dataset will help identify future extreme climatic events and can be also used to improve process - 370 based model s for prediction, adaptation , and mitigation strategies." 402 1508 W4283373401.pdf 17 5 separator 0.92419624 371 ¶ 1509 1516 W4283373401.pdf 17 6 title 0.9644483 Author contributions 1516 1537 W4283373401.pdf 17 7 separator 0.8159521 372 ¶ 1538 1545 W4283373401.pdf 17 8 text 0.8928034 "Rongzhu Qin and Feng Zhang calculated the dataset, analyzed the results , and wrote the 373 manuscript; all other authors reviewed and revised the manuscript." 1545 1708 W4283373401.pdf 17 9 separator 0.81186706 374 ¶ 1709 1716 W4283373401.pdf 17 10 title 0.94316345 Competing interests 1716 1736 W4283373401.pdf 17 11 paratext 0.3207889 375 1737 1741 W4283373401.pdf 17 12 separator 0.9496808 ¶ 1742 1744 W4283373401.pdf 17 13 text 0.89258945 The authors declare that they have no conflict of interest. 1744 1804 W4283373401.pdf 17 14 paratext 0.60156 376 1805 1809 W4283373401.pdf 17 15 text 0.51942223 https 1809 1815 W4283373401.pdf 17 16 paratext 0.5857868 ://doi. 1815 1822 W4283373401.pdf 17 17 text 0.6281446 org 1822 1825 W4283373401.pdf 17 18 paratext 0.7438913 /10.5194/ 1825 1834 W4283373401.pdf 17 19 text 0.5650062 essd 1834 1838 W4283373401.pdf 17 20 paratext 0.8623421 "-2022-79 Open Access Earth System Science" 1838 1886 W4283373401.pdf 17 21 separator 0.9016092 ¶ 1888 1890 W4283373401.pdf 17 22 title 0.74074143 DataDiscussions 1890 1906 W4283373401.pdf 17 23 separator 0.90841377 ¶ 1906 1908 W4283373401.pdf 17 24 paratext 0.9421768 "Preprint. Discussion started: 4 April 2022 c Author(s) 2022. CC BY 4.0 License." 1908 1990 W4283373401.pdf 17 25 separator 0.996892 ¶ 1990 1992 W4283373401.pdf 17 0 paratext 0.9902817 Foods 2021 ,10, 1960 5 of 12 0 28 W3194860153.pdf 4 1 separator 0.9953919 ¶ 28 30 W3194860153.pdf 4 2 title 0.92618036 Table 1. Composition and physicochemical properties of MCC solutions mixed with 0 (S-MCC-0G), 10 (S-MCC-10G), and 30 144 W3194860153.pdf 4 3 separator 0.96776724 ¶ 144 146 W3194860153.pdf 4 4 table 0.8420426 20 (S-MCC-20G) % GMP as a percentage of total protein. 146 201 W3194860153.pdf 4 5 separator 0.86954486 ¶ 201 203 W3194860153.pdf 4 6 table 0.9865401 "Parameter S-MCC-0G S-MCC-10G S-MCC-20G Total solids (%, w/w) 9.77 0.11a9.900.13a9.920.14a Protein (%, w/w) 8.64 0.08a8.580.09a8.590.18a Protein (%, w/w, dry basis) 88.5 0.72a86.70.31a86.61.21a Zeta potential (mV)" 203 433 W3194860153.pdf 4 0 paratext 0.9743861 Jurnal Informatika dan Komputer (JIKO) – Vol. 2, No. 2, September 2017 0 70 W2771981070.pdf 5 1 separator 0.78640866 "¶ ¶ ¶" 72 86 W2771981070.pdf 5 2 paratext 0.9811133 108 86 90 W2771981070.pdf 5 3 separator 0.9855031 ¶ 91 93 W2771981070.pdf 5 4 title 0.9830013 REFERENSI 94 104 W2771981070.pdf 5 5 separator 0.99613535 ¶ 106 108 W2771981070.pdf 5 6 bibliography 0.99306935 "[1] _____, “Pengertian Kos ”, http://libra ry.binus.ac.id/eColls/eThesisdoc/Bab2/2009 -1-00024 -AR%20Bab%202.pdf, tanggal akses 31 Januari 2016." 108 256 W2771981070.pdf 5 7 separator 0.98705566 ¶ 258 260 W2771981070.pdf 5 8 bibliography 0.99417 "[2] Andi Wahju Raharjo E, Jimmy Sentosa, “Perbandingan Kinerja Data Manipulation Language MongoDB dan SQL Server ”, http://www.andiwre.itmaranatha.org/jurnal/P aper%20Andi%20WRE%20cs%20 - %20Seminasik%202013%20v%20prosiding.pdf, tanggal akses 26 September 2015, 2013" 260 534 W2771981070.pdf 5 9 separator 0.98192334 ¶ 536 538 W2771981070.pdf 5 10 bibliography 0.99538827 [3] _____, “PHP MongoDB ”, http://php.net/manual/en/book.mongo.php, tanggal akses 18 September 2015. 538 640 W2771981070.pdf 5 11 separator 0.8814461 ¶ 642 644 W2771981070.pdf 5 12 bibliography 0.9943663 [4] _____, “MongoDB Manual ”, http://docs.mongodb.org/manual /crud, tanggal akses 18 September 2015. 644 746 W2771981070.pdf 5 13 separator 0.9940921 ¶ 748 750 W2771981070.pdf 5 0 title 0.99011433 Supplementary table 2 Single-dose toxici ty study of HER2-lytic in mice 0 72 W4362478737.pdf 0 1 separator 0.9953072 ¶ 74 76 W4362478737.pdf 0 2 table 0.96536636 "Dose of HER2-lytic ( iv) The number of dead mice/ total tested mice 10mg/kg 20mg/kg0/53/5 gg 40mg/kg 5/5 N=5" 76 196 W4362478737.pdf 0 3 separator 0.893549 ¶ 196 198 W4362478737.pdf 0 4 text 0.81448835 "BALB/c mice were received HER2-lytic peptide as intravenous injections (50 μl/injection" 198 289 W4362478737.pdf 0 5 table 0.45757124 ) 289 290 W4362478737.pdf 0 6 text 0.5362726 μl/injection) . 290 305 W4362478737.pdf 0 7 separator 0.99318206 ¶ 305 307 W4362478737.pdf 0 8 table 0.3565526 Supplement 307 318 W4362478737.pdf 0 9 caption 0.6112432 ary 318 321 W4362478737.pdf 0 10 table 0.51041263 Table 2 Kawamoto et al. 321 345 W4362478737.pdf 0 0 paratext 0.97467834 "3 Vol.:(0123456789) Scientific Reports | (2022) 12:3707 | https://doi.org/10.1038/s41598-022-07689-0" 0 112 W4220727343.pdf 2 1 separator 0.99463814 ¶ 112 114 W4220727343.pdf 2 2 text 0.99929184 "www.nature.com/scientificreports/funerary practices. From these results, one can conclude that only the central area of Aebutia ’s body (vertebrae) was exposed to a mild heat source at ca. 200 °C. Moreover, the presence of intact and well-preserved garlands in the same sarcophagus makes unrealistic any scenario whereby a burning process started within the sarcophagus itself." 114 501 W4220727343.pdf 2 3 separator 0.98442996 ¶ 501 503 W4220727343.pdf 2 4 text 0.99970305 "As to the remains collected from A1, distinct heating conditions were unveiled, in particular, by the INS data (Fig. 4A,B). While the fibula and rib4 appear to have been subjected to temperatures of ca. 700 °C, specimens from the radius, cranium2 and clavicles1, 2 and 3 were burned at higher temperatures. This is corroborated by the FTIR-ATR and Raman spectra, the infrared OH libration being detected for rib4, clavicles 1, 2 and 3, radius and cranium2 (at ca. 660 cm−1) but not for the fibula (Fig. 4C), while the Raman spectra of the clavicle1, radius and cranium2 comprise the typical narrow and intense ν1(PO4) phosphate signal from hydroxyapatite (typical of high burning temperatures) as opposed to the spectrum from the rib (Fig. 4D). These vibrational profiles are compatible with a heating temperature of about 800–900 °C. Additionally, there is a noticeable variation in the relative intensity of the Raman bands at 480 and 490 cm−1 from the triply degenerate phosphate mode (ν4(OPO), Fig. 4D), evidencing the presence of distinct hydroxyapatite polymorphic phases, in different amounts in each of these samples. This indicates that the bone fragments from the clavicle, radius and cranium2 were not subject to exactly the same burning temperature (although always ≥ 800 °C). These skeletal remains also display a band at 725 cm−1 (Fig. 4A) which is ascribed to contamination with calcite. Since calcite was only detected for these skeletal remains found directly on the soil (and not for those found inside the sarcophagus), it may be suggested that this contamination is due to water percolation or to a bone treatment, such as the use of lime in funerary practices (see, e.g., Ref.18)." 503 2264 W4220727343.pdf 2 5 separator 0.99143994 ¶ 2264 2266 W4220727343.pdf 2 6 text 0.99964476 "Spectroscopic results reveal that the heating processes have occurred in an environment with a reduced oxy- gen availability (quasi-anaerobic conditions), as demonstrated by the presence of carbonate and cyanamide in the tibia sample as clearly evidenced by FTIR-ATR (Fig. 4C). The inclusion of cyanamide anion (NCN2−) within the bone ́s framework, identified through its infrared peaks at 702 and 2017 cm−1 (respectively from NCN deforma- tion and stretching modes), was previously only reported in bone heated at 650 °C and above under anaerobic" 2266 2827 W4220727343.pdf 2 7 separator 0.9769068 ¶ 2828 2830 W4220727343.pdf 2 8 caption 0.99227244 "Figure 2. Skeletal remains from the “Hypogeum of the Garlands” studied here. Samples are from Aebutia Quarta and one incinerated individual: AEBUTIA—1. Rib1; 2. Vertebra1; 3. Tibia; 4. Carpal (trapezium); 5. Rib2; 6. Cranium1; 7. Rib3; 8. Vertebra2; 9. Vertebra3; 10. Vertebra4. Individual A1–11. Fibula; 12. Rib4; 13. Craniuml2; 14. Pelvis with white concretions in the upper region; 15. Rock1 fragment; 16. Radius; 17. Clavicle1; 18. Clavicle2; 19. Clavicle3; 20. Vertebra5 with white concretions in the lower region; 21. Rock2 fragment." 2830 3383 W4220727343.pdf 2 9 separator 0.9946662 ¶ 3384 3386 W4220727343.pdf 2 10 text 0.64021677 Details are reported in the “ Methods and materials ” section. 3386 3449 W4220727343.pdf 2 0 text 0.9985099 "Th is understanding is somewhat at variance to traditional clinical practice, supported by current guide-lines that recommend haemodynamic resuscitation follows a step-wise approach – initial fl uid loading, followed by the use of an inotrope to improve cardiac output, followed by a vasopressor to squeeze the circulation to augment the perfusion pressure [7]." 0 367 W2153888810.pdf 1 1 separator 0.99139273 ¶ 367 369 W2153888810.pdf 1 2 text 0.99813086 "Th ree recently published randomised controlled trials comparing the eff ects of catecholamines in severe sepsis have demonstrated equivalence in haemodynamic responses without adverse eff ects on organ function or mortality [8-10]. Of the three catecholamines studied, norepinephrine was associated with the lowest incidence of drug-specifi c side eff ects compared with epinephrine (hyperlactataemia and hyperglycaemia) and dopamine (arrhythmias). On the basis of these studies and a recent commentary [11], norepinephrine appears to be the initial agent of choice. Furthermore, these trials represent a perceptible change in clinical practice to preferentially use catecholamines early in resuscitation to defend MAP as the principal haemodynamic endpoint, although it is acknowledged that there is little evidence or agreement on an optimal perfusion pressure in septic shock [12]." 369 1267 W2153888810.pdf 1 3 separator 0.9922143 ¶ 1267 1269 W2153888810.pdf 1 4 text 0.99946326 "Th e justifi cation for selecting MAP is based on prag- matic reasons – MAP is easy and accurate to measure – as well as it being an aggregate index of organ perfusion pressure. However, as there is little direct relationship between perfusion pressure and venous return, which remains diffi cult to measure under clinical conditions, clinicians rely on the assumption that parallel changes in the arterial and venous circulations will occur." 1269 1717 W2153888810.pdf 1 5 separator 0.99115455 ¶ 1717 1719 W2153888810.pdf 1 6 text 0.9989672 "Th e use of norepinephrine as a neurohormonal aug- men tation therapy by Hamzaoui and colleagues demon-strated inotropic and vasopressor responses in a hetero-geneous population of patients with severe sepsis using current monitoring techniques [1]. Th ese data are consistent with established biological and basic science evidence, and provide addi tional strength to the argument for viewing nor epi nephrine as a neurohormone rather than as a vasopressor and to recommend its early use as the fi rst-line agent for life-threatening hypotension." 1719 2273 W2153888810.pdf 1 7 separator 0.99659985 ¶ 2273 2275 W2153888810.pdf 1 8 title 0.9555033 Abbreviations 2275 2289 W2153888810.pdf 1 9 separator 0.99602485 ¶ 2289 2291 W2153888810.pdf 1 10 text 0.609198 MAP , mean 2291 2302 W2153888810.pdf 1 11 title 0.7349252 arterial pressure.Competing interests 2302 2340 W2153888810.pdf 1 12 separator 0.9829137 ¶ 2340 2342 W2153888810.pdf 1 13 text 0.9396544 The author declares that he has no competing interests. 2342 2398 W2153888810.pdf 1 14 separator 0.9948303 ¶ 2398 2400 W2153888810.pdf 1 15 title 0.5261591 Author details 2400 2415 W2153888810.pdf 1 16 separator 0.97421074 ¶ 2415 2417 W2153888810.pdf 1 17 contact 0.9857669 "1Division of Critical Care and Trauma, The George Institute for Global Health, Level 7, 341 George Street, Sydney 2000, Australia. 2Department of Critical Care Medicine, University of New South Wales, Sydney, 2052, Australia. 3Department of Intensive Care Medicine, St George Hospital, Gray Street, Kogarah, Sydney 2217, Australia." 2417 2759 W2153888810.pdf 1 18 separator 0.90542793 ¶ 2759 2761 W2153888810.pdf 1 19 paratext 0.8653961 Published: 20 September 2010Reference 2761 2799 W2153888810.pdf 1 20 title 0.5547225 s 2799 2800 W2153888810.pdf 1 21 separator 0.99084306 ¶ 2800 2802 W2153888810.pdf 1 22 bibliography 0.99768776 "1. Hamzaoui O, Georger J-F, Monnet X, Ksouri H, Maizel J, Richard C, Teboul J-L: Early administration of norepinephrine increases cardiac preload and cardiac output in septic patients with life-threatening hypotension. Crit Care 2010, 14:R142." 2802 3052 W2153888810.pdf 1 23 separator 0.94010305 ¶ 3052 3054 W2153888810.pdf 1 24 bibliography 0.9976196 "2. Insel PA: Seminars in medicine of the Beth Israel Hospital, Boston. Adrenergic receptors-evolving concepts and clinical implications. N Engl J Med 1996, 334: 580-585." 3054 3230 W2153888810.pdf 1 25 separator 0.91436076 ¶ 3230 3232 W2153888810.pdf 1 26 bibliography 0.9977253 "3. Hein L: Adrenoceptors and signal transduction in neurons. Cell Tissue Res 2006, 326: 541-551." 3232 3332 W2153888810.pdf 1 27 separator 0.9418826 ¶ 3332 3334 W2153888810.pdf 1 28 bibliography 0.9979304 "4. Bressack MA, Raffi n TA: Importance of venous return, venous resistance, and mean circulatory pressure in the physiology and management of shock. Chest 1987, 92:906-912." 3334 3513 W2153888810.pdf 1 29 separator 0.9380096 ¶ 3513 3515 W2153888810.pdf 1 30 bibliography 0.9978907 "5. Jacobsohn E, Chorn R, O’Connor M: The role of the vasculature in regulating venous return and cardiac output: historical and graphical approach. Can J Anaesth 1997, 44:849-867." 3515 3702 W2153888810.pdf 1 31 separator 0.94281316 ¶ 3702 3704 W2153888810.pdf 1 32 bibliography 0.9977033 "6. Myburgh JA: An appraisal of selection and use of catecholamines in septic shock – old becomes new again. Crit Care Resusc 2006, 8:353-360." 3704 3849 W2153888810.pdf 1 33 separator 0.9768963 ¶ 3849 3851 W2153888810.pdf 1 34 bibliography 0.9977897 "7. Dellinger RP , Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327." 3851 4278 W2153888810.pdf 1 35 separator 0.9792737 ¶ 4278 4280 W2153888810.pdf 1 36 bibliography 0.9979628 "8. Annane D, Vignon P , Renault A, Bollaert PE, Charpentier C, Martin C, Troche G, Ricard JD, Nitenberg G, Papazian L, Azoulay E, Bellissant E: Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial. Lancet 2007, 370: 676-684." 4280 4569 W2153888810.pdf 1 37 separator 0.9629376 ¶ 4569 4571 W2153888810.pdf 1 38 bibliography 0.99794036 "9. Myburgh JA, Higgins A, Jovanovska A, Lipman J, Ramakrishnan N, Santamaria J: A comparison of epinephrine and norepinephrine in critically ill patients. Intensive Care Med 2008, 34:2226-2234." 4571 4772 W2153888810.pdf 1 39 separator 0.9662896 ¶ 4772 4774 W2153888810.pdf 1 40 bibliography 0.9979894 "10. De Backer D, Biston P , Devriendt J, Madl C, Chochrad D, Aldecoa C, Brasseur A, Defrance P , Gottignies P , Vincent JL: Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med 2010, 362: 779-789." 4774 5007 W2153888810.pdf 1 41 separator 0.9537872 ¶ 5007 5009 W2153888810.pdf 1 42 bibliography 0.9977968 "11. Maybauer MO, Walley KR: Best vasopressor for advanced vasodilatory shock: should vasopressin be part of the mix? Intensive Care Med 2010, 36:1484-1487." 5009 5171 W2153888810.pdf 1 43 separator 0.94431025 ¶ 5171 5173 W2153888810.pdf 1 44 bibliography 0.99238604 "12. Shapiro DS, Loiacono LA: Mean arterial pressure: therapeutic goals and pharmacologic support. Crit Care Clin 2010, 26:285-293, table. doi:10.1186/cc9246" 5173 5335 W2153888810.pdf 1 45 separator 0.94340205 ¶ 5335 5337 W2153888810.pdf 1 46 paratext 0.8292456 "Cite this article as :" 5337 5362 W2153888810.pdf 1 47 bibliography 0.8744467 "Myburgh J: Norepinephrine: more of a neurohormone than a vasopressor. Critical Care 2010, 14:196.Myburgh Critical Care 2010," 5362 5493 W2153888810.pdf 1 48 paratext 0.87484396 "14:196 http://ccforum.com/content/14/5/196Page 2 of 2" 5493 5550 W2153888810.pdf 1 0 paratext 0.9656478 "International Journal of Education, Social Science & Humanities. Finland Academic Research Science Publishers ISSN: 2945 -4492 (online) | (SJIF) = 7.502 Impact factor" 0 177 W4379374720.pdf 5 1 separator 0.64724004 ¶ 179 181 W4379374720.pdf 5 2 paratext 0.93632233 "Volume -11| Issue -5| 202 3 Published: |22-05-202 3| ¶ 2275 Publishing centre of Finland" 181 285 W4379374720.pdf 5 3 bibliography 0.9961542 "13. Садикова М. И. и др. КАТАЛИТИЧЕСКАЯ ОЧИСТКА ГАЗОВ //ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ. – 2023. – Т. 20. – No. 1. – С. 43 -47." 286 433 W4379374720.pdf 5 4 separator 0.96158636 ¶ 434 436 W4379374720.pdf 5 5 bibliography 0.99723893 "14. Садикова М. И. и др. МИНЕРАЛЬНОЕ И ОРГАНИЧЕСКОЕ СЫРЬЕ //ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ. – 2023. – Т. 20. – No. 1. – С. 51 -55." 436 587 W4379374720.pdf 5 6 separator 0.9689357 ¶ 588 590 W4379374720.pdf 5 7 bibliography 0.99696076 "15. Садикова М. И. СВЕРХКРИТИЧЕСКАЯ ХРОМАТОГРАФИЯ (СКФХ) ЭКСТРАКТОВ ЦВЕТКОВ ДЖИДЫ И ЛИСТЬЕВ ЩЕЛКОВИЦЫ //Главный редактор. – 2022. – С. 62." 590 735 W4379374720.pdf 5 8 separator 0.96642387 ¶ 737 739 W4379374720.pdf 5 9 bibliography 0.99781626 "16. Bobir O., Mashhura S., Islom B. TECHNOLOGY OF OBTAINING EFFECTIVE CORROSION IN HIBITORS IN THE OIL AND GAS INDUSTRY //Universum: технические науки . – 2022. – No. 1 -3 (94). – С. 85-87." 739 935 W4379374720.pdf 5 10 separator 0.9684677 ¶ 936 938 W4379374720.pdf 5 11 bibliography 0.9977959 "17. Шарипов М. З. и др. Influence of hexagonal symmetry stresses on domain structure and magnetization process of FeBO3 single crystal //Eurasian Physic al Technical Journal. – 2020. – Т. 17. – No. 1 (33). – С. 65 -72." 938 1163 W4379374720.pdf 5 12 separator 0.97420776 ¶ 1164 1166 W4379374720.pdf 5 13 bibliography 0.9977448 "18. Атоев Э. Х. Исследование взаимодействия солей хрома и цинка с различными органическими реагентами //Консолидация интеллектуальных ресурсов как фундамент развития современной науки. – 2021. – С. 324 -330." 1166 1381 W4379374720.pdf 5 14 separator 0.9673102 ¶ 1382 1384 W4379374720.pdf 5 15 bibliography 0.99741966 "19. Атоев Э. Х. ТЕРМИЧЕСКИЕ ПРЕВРАЩЕНИЯ АМОРФНОГО ГИДРОКСИДА ЖЕЛЕЗА //Прогрессивные технологии и процессы. – 2018. – С. 23 -24." 1384 1518 W4379374720.pdf 5 16 separator 0.97090757 ¶ 1519 1521 W4379374720.pdf 5 17 bibliography 0.99783266 "20. Атоев Э. Х., Гафурова Г. А. Рафинирование и экстракция семян тыквы сверхкритической углекислотой //Universum: технические науки. – 2020. – No. 5 -2 (74). – С. 26 -28." 1521 1697 W4379374720.pdf 5 18 separator 0.96430516 ¶ 1698 1700 W4379374720.pdf 5 19 bibliography 0.99753875 "21. Атоев Э. Х. ГЕТЕРОЦИКЛИЧЕСКИЕ ОКСИАЗОСОЕДИНЕНИЯ КАК АНАЛИТИЧЕСКИЕ РЕАГЕНТЫ //Universum: химия и биология. – 2021. – No. 3-2 (81). – С. 4-6." 1700 1849 W4379374720.pdf 5 20 separator 0.96736157 ¶ 1850 1852 W4379374720.pdf 5 21 bibliography 0.99762946 "22. Атоев Э. Х. Строение и свойства внутрикомплексных соеди нений 8 - меркаптохинолина (тиооксина) и его производных //Universum: химия и биология. – 2020. – No. 10 -2 (76). – С. 29 -32." 1852 2043 W4379374720.pdf 5 22 separator 0.9686246 ¶ 2044 2046 W4379374720.pdf 5 23 bibliography 0.9968063 "23. Атоев Э. Х. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМЕ ОБРАЗОВАНИЯ СОЕДИНЕНИЯ С АНТИПИРИНОМ И ЕГО ПРОИЗВОДНЫМИ //Universum: химия и био логия. – 2021. – No. 10 -2 (88). – С. 42-43." 2046 2234 W4379374720.pdf 5 24 separator 0.97087044 ¶ 2235 2237 W4379374720.pdf 5 25 bibliography 0.99752903 "24. Атоев Э. Х. ИССЛЕДОВАНИЕ РЕАКЦИЙ О, О - ДИОКСИАЗОСОЕДИНЕНИЙ //Universum: химия и биология. – 2022. – No. 9 - 2 (99). – С. 35 -37." 2237 2374 W4379374720.pdf 5 0 paratext 0.9903501 Entropy 2019 ,21, 416 3 of 19 0 29 W2938458899.pdf 2 1 separator 0.9956182 ¶ 29 31 W2938458899.pdf 2 2 title 0.9076492 "Table 1. A summary of the related research studies for multi-occupancy environment in the context of the type of sensors used, data association, and the approaches used as well as the results obtained." 31 235 W2938458899.pdf 2 3 separator 0.9905466 ¶ 235 237 W2938458899.pdf 2 4 table 0.9905372 "Reference Type of Sensors Data Association Approach Overall Accuracy [4] Ambient sensors yes Markov Modulated Poisson Process (MMPP) 82.3% [5] Ambient sensors no Factorial Hidden Markov Model (FHMM) and Nonlinear Bayesian Tracking 64% [20] Motion sensor yes Finite-set statistics (FISST) and Bayesian filtering - [21] Ambient and smartphone sensor no Coupled Hidden Markov Model (CHMM) and HMM 70% [22] Wearable sensors no K-NN, SVM, GMM and RF - [23] Infrastructure yes Conditional Random Field (CRF) 81.3% [24] Infrastructure yes 2 HMMs 84% [25] Infrastructure no Incremental Decision Trees (IDT) 40% [14,26] Infrastructure yes HMM and CRF - [27] Infrastructure yes HMM, DT, KNN. TDNN and MLP 84.6% [28] Motion sensor and wearable no Bayesian framework 80.2% [29] Video encoder no Linear Signal Model for Hybrid and Video Decoding 90% [30] Passive sonar yes The probabilistic data association (PDA) 85% [31] CCTV cameras no HMM 98.3% [32] Motion sensor yes Markov chain Monte Carlo (MCMC) 82% [33] Passive sonar no SVM 83.5%" 237 1295 W2938458899.pdf 2 5 separator 0.99641985 ¶ 1295 1297 W2938458899.pdf 2 6 text 0.9817041 Recent advances in identifying activities in multi-occupant environments are presented in [ 17]. 1297 1394 W2938458899.pdf 2 7 separator 0.9367267 ¶ 1394 1396 W2938458899.pdf 2 8 text 0.99972254 "There are many published papers related to pattern recognition that conducted their research to detect HAR in a home environment using a range of different machine learning techniques, including HMM [ 34,35]. In [ 5], the Factorial Hidden Markov Model (FHMM) and Nonlinear Bayesian Tracking method are applied and compared for tracking and recognizing human activity. The FHMM is used to model two separate Markov chains corresponding to two users whereas Nonlinear Bayesian Tracking is used to break down the observation area into the number of users. The authors indicated that the Nonlinear Bayesian Tracking method performs better than FHMM (the performance of Bayesian Tracking was 67.9% , while the performance of FHMM was 59.5% ). The authors in [ 4] proposed a new model based on the Markov Modulated Poisson Process (MMPP), an unsupervised method that detects visitors in a smart home environment occupied by an older adult living alone. The ambient sensors are installed in specific locations to cover most of the movement without affecting the routine activities of the occupier. Multiple datasets are used in their research based on the data collected from two apartments. The results of their study show that when MMPP is applied on both datasets, a recall of78.4% and a precision of 74.9% were achieved for their first dataset, whereas 80.1% recall and 84.2% precision have resulted from their second dataset." 1396 2846 W2938458899.pdf 2 9 separator 0.9843179 ¶ 2846 2848 W2938458899.pdf 2 10 text 0.99962753 "Using embedded sensors in smartphones, including built-in microphones, to recognize multi-occupancy activities is reported in [ 36]. A recent survey by [ 37] presents an overview of wearable sensors and bespoke sensors’ usage in activity recognition of multi-occupant environments." 2848 3134 W2938458899.pdf 2 11 separator 0.9852927 ¶ 3134 3136 W2938458899.pdf 2 12 text 0.9997441 "The paper highlights the cooperative interaction activities and complex activity recognition in smart homes. The authors of [ 21] proposed a hybrid approach to recognizing the complex activities of ADL using a smartphone-based sensor. First, different activities such as walking and sitting are extracted by the smartphone accelerometer data, followed by the application of HMM for each person, while the hidden stats are used for the locations of the occupant. Finally, Coupled Hidden Markov Model (CHMM) is constructed to infer the persons’ activities in a multi-occupancy environment. The hidden stats of the CHMM and HMM refer to the activities, whereas the observations of the CHMM and HMM indicate both the location and posture of the individual. The results obtained with five people demonstrated that their proposed method improves the accuracy up to 70%, compared to 30% when only accelerometer data is used. Nevertheless, the cooperative activities, where many residents work together in a cooperative manner such that each person does certain actions of the same activity or together (e.g., two persons moving a table by holding it by the ends), were ignored in this research." 3136 4345 W2938458899.pdf 2 13 separator 0.98804146 ¶ 4345 4347 W2938458899.pdf 2 14 text 0.99926174 "In [22] the authors present an overview of different classification techniques used to recognize human activity based on wearable sensors. They used four supervised classification techniques namely" 4347 4545 W2938458899.pdf 2 0 paratext 0.87590885 "A cultura na sala de aula e a interdisciplinaridade Revista NUPEM, Campo Mourão, v.3, n.5, ago./dez.2011" 0 106 W4008612.pdf 8 1 separator 0.98758405 ¶ 106 108 W4008612.pdf 8 2 text 0.9959737 "143social; com a internet também os jovens desejam se sentir parte deste mundo moderno. Este período que vivemos causa rupturas nas identidades tradicionais provocando a fragmentação e o hibridismo. Atualmente pensar a diferença tem sido ponto atualíssimo no mundo, preconceitos são abolidos e a convivência é fundamental em um mundo em conflito." 108 458 W4008612.pdf 8 3 separator 0.843737 ¶ 458 460 W4008612.pdf 8 4 text 0.9995007 "Destarte a cultura possibilita a partir deste entendimento a explicação em si mesma, oferecendo reflexões parciais das razões do por que as pessoas pensam e se expressam em comportamentos específicos. O conhecimento da cultura num contexto gera um encontro com identidades múltiplas." 460 747 W4008612.pdf 8 5 separator 0.9549584 ¶ 747 749 W4008612.pdf 8 6 text 0.9994164 "A prática docente guarda estrita correspondência com a cultura na qual ela se organiza, de modo que ao analisarmos uma determinada situação, poderemos inferir não só os conteúdos que, explícita ou implicitamente, são vistos como importantes naquela cultura, como também de que maneira aquela cultura prioriza alguns temas em detrimento de outros, isto é, podemos inferir quais foram os critérios de escolha que guiaram os professores." 749 1193 W4008612.pdf 8 7 separator 0.9754256 ¶ 1193 1195 W4008612.pdf 8 8 text 0.9988375 "Cabe ressaltar a quase inexistência de pesquisas que possam discutir a influência cultural na formação educacional no estado de Mato Grosso do Sul. Acreditamos que a influência das artes são constituidoras de sujeitos e a realidade de Coxim permite que possamos refletir sobre essa absorção, capacidade de resistência, renovação e novas possibilidades criativas." 1195 1570 W4008612.pdf 8 9 separator 0.9953067 ¶ 1570 1572 W4008612.pdf 8 10 title 0.97998184 Interdisciplinaridade 1572 1594 W4008612.pdf 8 11 separator 0.9925909 ¶ 1594 1596 W4008612.pdf 8 12 text 0.999274 "A cultura interdisciplinar precisa ser assimilada com prazer cada vez maior e definitivamente implantada para a superação e renovação da prática educativa escolar, segundo Fazenda (2002) com seu leque de possibilidades subjetivas, criativas, afetivas, na ação objetiva, para a formação cultural do sujeito." 1596 1909 W4008612.pdf 8 13 separator 0.9646269 ¶ 1909 1911 W4008612.pdf 8 14 text 0.9996993 "Ivani Fazenda (2001) é a pioneira nos estudos interdisciplinares no Brasil, autora de várias obras. As primeiras pesquisas revelaram professores bloqueados nas suas criações, robotizados nas tarefas cotidianas, desapontados e alienados. A interdisciplinaridade, como tudo que é inovador, indica nova postura e transformações nas práticas docentes. Em vista disso a busca de novas alternativas e a conquista de uma nova atitude, nova visão, nova reflexão sobre a existência." 1911 2388 W4008612.pdf 8 15 separator 0.97304004 ¶ 2388 2390 W4008612.pdf 8 16 text 0.9996852 "Fazenda (1995) partiu da necessidade do professor trazer o conhecimento vivenciado, não só refletido, mas percebido e sentido. Gestando estas ideias, o sujeito na perspectiva interdisciplinar duvida das teorias postas e inquestionáveis, compreendendo como incompletas para as práticas cotidianas e existenciais. Parte-se para a busca da marca registrada, pessoal, na práxis. Esta marca registrada passa pela subjetividade, pela metáfora interior." 2390 2840 W4008612.pdf 8 17 separator 0.95499504 ¶ 2840 2842 W4008612.pdf 8 18 text 0.99927044 "A pesquisa interdisciplinar tem sido orientada pela recuperação das histórias de vida, a utilização dos recursos da hermenêutica, o uso das" 2842 2985 W4008612.pdf 8 0 text 0.9985739 "expected for the impregnation of HPW (reported in ESI, Fig. SX †). The presence of HPW is also con rmed by the appearance of a new O 1s peak at 530 eV assigned to O-atom inWO 3. Interestingly enough, the Nb 3d signal was signi cantly broadened in the SPION-Nb30@HPW-R5 indicating a change inits chemical environment a erve recovery and reuse process, but especially it is possible to see the disappearance of thedoublet corresponding to the Fe 2+2p indicating the oxidation of magnetite to maghemite. In short, the changes in the oxidation state of iron, in the chemical environment of Nb and the decrease in concentration of acidic sites, especially of Bronstedacid sites, may be responsible for the increase in polymer yieldas a function of the number of reuse cycles." 0 792 W3152963436.pdf 7 1 separator 0.99693674 ¶ 792 794 W3152963436.pdf 7 2 title 0.9859088 Conclusion 794 805 W3152963436.pdf 7 3 separator 0.9953896 ¶ 805 807 W3152963436.pdf 7 4 text 0.99978405 "The pinene isomerization reaction was chosen as model tostudy the catalytic activity and reusability of SPION-Nb30impregnated with HPW. The superparamagnetic character conferred by SPION is fundamental since avoid self- agglomeration while incorporating the possibility of magneticprecipitation and recovery. This strategy is more convenient andfaster than using ltration and conventional precipitation techniques for separation of the catalyst from the reactionmedium, in addition to save energy and time. A reusable andefficient catalyst for isomerization of turpentine oil (80 to 100% conversion of pinenes) to valuable terpenes such as camphene and limonene ( /C2450%) was achieved by treatment of SPION-Nb30 with HPW. This combination generates new Lewis and Bronsted acidicactive sites and/or a synergic e ffect, as induced by the use of toluene as solvent in combination with ultrasound probe, since theisolated components showed signi cantly lower selectivity for camphene and limonene, in addition to larger yield of polymericby-products. These probably is consequence of slow changesinduced to the catalyst by the catalytic reaction such as oxidation of SPION from magnetite to maghemite, decrease in the concentra- tion and nature of the active acid sites, and change in the chemicalenvironment of the Nb sites. The good performance and selectivityeven a er the h reuse cycle indicate the good stability of the catalyst and good e fficiency of the magnetic recovery, associated with low leaching, demonstrating the high potentiality of theoptimized material and process." 807 2413 W3152963436.pdf 7 5 separator 0.9966037 ¶ 2413 2415 W3152963436.pdf 7 6 title 0.9863016 Experimental section 2415 2436 W3152963436.pdf 7 7 separator 0.9909365 ¶ 2436 2438 W3152963436.pdf 7 8 title 0.58156705 Materials 2438 2448 W3152963436.pdf 7 9 separator 0.97372276 ¶ 2448 2450 W3152963436.pdf 7 10 text 0.9997444 "All chemicals were acquired commercially from Aldrich or Merck Company and used without further puri cation. Crude turpentine oil, pure a-pinene and b-pinene were donated by SOCER RB Company. Turpentine oil compo sition was evaluated by GC-MS using hexadecane as internal standard: 54 –55% a-pinene, 44 – 45%b-pinene and 1 –2% camphene. A Q700W Q-Sonica ultrasonic probe operating at frequency of 20 kHz was used in the experi- ments. The GC-MS analyzes were performed in a Shimadzu model GCMS-QP2010 ULTRA equipment. Niobium chloride (NbCl 5)w a s kindly donated by Prof. Dr Thiago Canevari. Toluene, diethylene glycol, tetramethyl ammonium, hydrogen peroxide (30 wt%),tetrahydrofuran (THF) and ammonium hydroxide (99.8 wt%) were purchased from Merck®. Superp aramagnetic iron oxide nano- particles (SPIONs), 7 nm large, was prepared by thermo-decomposition process, as described previously." 2450 3368 W3152963436.pdf 7 11 separator 0.9689975 ¶ 3368 3370 W3152963436.pdf 7 12 paratext 0.91452944 35,57 –59 3370 3380 W3152963436.pdf 7 13 separator 0.99205136 ¶ 3380 3382 W3152963436.pdf 7 14 title 0.98918873 Characterization methods 3382 3407 W3152963436.pdf 7 15 separator 0.9926369 ¶ 3407 3409 W3152963436.pdf 7 16 text 0.99964267 "Transmission electron microscopy (TEM) images were obtained using a JEOL, model JEM 2100 FEG-TEM (at National Nano-technology Laboratory –LNNANO, of the National Center for Energy and Materials Research –CNPEM, or at the Analytical Center of Institute of Chemistry of University of Sao Paulo)equipped with a LaB 6lament gun, Maximum acceleration voltage: 200 kV, Resolution: 0.23 nm (dot). The crystallinestructures of samples were surveyed by X-ray di ffractometry (XRD) using a Brucker D2 Phaser with Cu K aradiation ( l1⁄4 1.5418 angstrom) at 20 keV. The Dispersive Energy X-ray uo- rescence spectra (EDX) were obtained at 25/C14C in a Shimadzu EDX-720 equipment, with a Rh tube as X-ray source, 15 –50 kV voltage and a Si(Li) semiconductor detector cooled by liquidnitrogen. The solid samples were analyzed as powder placedonto Mylar® lm in a 30 mm diameter sample holder, while liquid samples were placed onto Mylar® lms in a 10 mm diameter sample holder and let dry under vacuum. The surface area and pore size were measured by nitrogen gas adsorption ina Gemini VII equipment, and isotherm curve analysis wascarried out by BET method. The magnetization curves of solidsamples were obtained using a vibrating sample magnetometermanufactured by EG&G Princeton A pplied Research-model 4500. A QSONICA 700 watts ultrasonic probe was utilized in the reactionssetting the pulse time to 15 s and the rest time to 15 s. The particles size and zeta potential measurements were carried out in a Mal- vern Zetasizer Nano ZS equipment using samples dispersed inwater. The acidic sites were determined by pyridine adsorptionassay as monitored by FTIR, and spectra acquired in a ALPHABruker Spectrophotometer, in transmission mode, with samplesdispersed in KBr pellets. The chemical composition of the passivelm was analyzed by X-ray photoelectron spectroscopy (XPS) using a ThermoVG K-alpha + spectrometer operating with Al-K aradia- tion source. The pressure in the analysis chamber was 5 /C210 /C08 mPa and the spot size was 400 mm .T h ee n e r g ys c a l ew a sc a l i b r a t e d with respect to the adventitious C 1s peak at 284.8 eV. Peak tting was carried out with the Avantage v5.9912 so ware using a combination of Lorentzian and Gaussian line shapes and theSmart algorithm for background subtraction." 3409 5767 W3152963436.pdf 7 17 separator 0.9971813 ¶ 5767 5769 W3152963436.pdf 7 18 title 0.9932178 Synthesis of SPION-Nb30 catalyst 5769 5802 W3152963436.pdf 7 19 separator 0.99335647 ¶ 5802 5804 W3152963436.pdf 7 20 text 0.99404556 "The Nb precursor solution was prepared by dissolving 6.75 g of niobium( V) chloride (0.025 mols) in 200 mL of diethylene glycol (DEG) upon heating to approximately 180/C14C for two hours. The light green solution was cooled to 50/C14C and ltered using a quantitative paper lter to remove eventual impurities. SPIONs were prepared by thermo-decomposition reaction of iron( III) precursor in a high boiling temperature solvent.35,60 Briey, a solution containing 5 mmol of an iron( III) complex was heated to 180/C14C for 30 minutes, and the temperature increased to 230/C14C for 30 minutes. A er cooling, the product was " 5804 6448 W3152963436.pdf 7 21 separator 0.84358954 ¶ 6448 6449 W3152963436.pdf 7 22 paratext 0.9440926 "14210 |RSC Adv. ,2 0 2 1 , 11,1 4 2 0 3 –14212 © 2021 The Author(s). Published by the Royal Society of ChemistryRSC Advances Paper Open Access Article. Published on 15 April 2021. Downloaded on 5/18/2024 2:42:54 AM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. View Article Online" 6449 6780 W3152963436.pdf 7 0 math 0.6907046 "u 0 5 -4 ~ 3 c 2 CLI ... 1 ~ 0 c -1 CLI ... :::s ... ""'" 0 73 W4241528769.pdf 116 1 table 0.5846615 ... 0 ~ ~ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ~ ~ ~ ~ ~ ~ ~ 73 126 W4241528769.pdf 116 2 math 0.5098795 - 126 127 W4241528769.pdf 116 3 table 0.59531564 Average 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 127 182 W4241528769.pdf 116 4 math 0.80736446 ¶ ~ ~ ~ ~ 0 ~ ~ ~ 0 0 ~ ~ ~ ~ ~ 0 0 0 0 0 ~ 0 0 ~ -95% Confidence N rl N m ~ L/') I.D ,.... co 0'\ 0 rl N rl N m ..;:t L/') I.D ,.... co m 0 rl rl rl rl rl rl rl ¶ 183 348 W4241528769.pdf 116 5 table 0.64317745 "CLI c. E ~ AM PM Time" 348 376 W4241528769.pdf 116 6 separator 0.98680574 ¶ 377 379 W4241528769.pdf 116 7 title 0.82169074 "B1.46: Warren Stevens (WS) average (mean) typical day temperature difference between sun and shade loggers during the month of June" 379 514 W4241528769.pdf 116 8 table 0.38512844 2008 514 519 W4241528769.pdf 116 9 separator 0.9190173 ¶ 520 522 W4241528769.pdf 116 10 math 0.7740341 "-u 6 0 -5 ~ 4 c 3 CLI ... 2 CLI :a: 1 c 0 CLI -1 ... -2 :::s ... ra ... 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -Average 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -95% Confidence N rl N m ..;:t L/') I.D ,.... 00 0'\ 0 rl N rl N m ..;:t L/') I.D """" 00 0'\ 0 rl CLI rl rl rl rl rl rl ¶" 522 836 W4241528769.pdf 116 11 table 0.50797737 c. 836 839 W4241528769.pdf 116 12 math 0.57568383 ¶ 840 842 W4241528769.pdf 116 13 table 0.5561453 "E ~ AM PM Time" 842 863 W4241528769.pdf 116 14 separator 0.9888558 ¶ 864 866 W4241528769.pdf 116 15 title 0.81357604 "B1.47: Warren Stevens (WS) average (mean) typical day temperature difference between sun and shade loggers during the month of" 866 996 W4241528769.pdf 116 16 table 0.40582728 996 997 W4241528769.pdf 116 17 title 0.4221617 July 997 1001 W4241528769.pdf 116 18 table 0.43538722 2008 1001 1006 W4241528769.pdf 116 19 separator 0.9406374 ¶ 1007 1009 W4241528769.pdf 116 20 math 0.7557755 "-u 0 8 - ~ 6 e 4 CLI ... ~ 2 c 0 CLI -2 ... :::s 0 0 0 0 0 0 0 ~ ~ 0 ~ ~ 0 0 0 0 0 0 0 0 -Average 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ... ra ... 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 -95% Confidence m ..;:t L/') I.D ,.... 00 0'\ 0 rl N rl N m ..;:t L/') I.D """" 00 0'\ 0 rl CLI .-I .-I .-I .-I .-I c. E ~ AM PM ¶" 1009 1354 W4241528769.pdf 116 21 table 0.66318274 Time 1354 1359 W4241528769.pdf 116 22 separator 0.99108875 ¶ 1360 1362 W4241528769.pdf 116 23 title 0.9139929 "Bl.48: Warren Stevens (WS) average (mean) typical day temperature difference between sun and shade loggers during the month of August 2008" 1362 1504 W4241528769.pdf 116 24 separator 0.99058753 ¶ 1505 1507 W4241528769.pdf 116 25 paratext 0.88200265 105 1507 1511 W4241528769.pdf 116 0 paratext 0.9902211 Vadamala Prudhvi Raj, Int. J.Exp. Biomed. Res. 2023; 2(1): 17-26 0 64 W4379163852.pdf 6 1 separator 0.9896962 ¶ 64 66 W4379163852.pdf 6 2 text 0.99836886 "left hovering just above (noncontact mode). AFM is a helpful technology because it allows for mapping samples according to characteristics other than size, such as colloid connection rather than deformed resistance." 66 290 W4379163852.pdf 6 3 separator 0.9896189 ¶ 290 292 W4379163852.pdf 6 4 title 0.6676701 292 293 W4379163852.pdf 6 5 text 0.5053375 Both 293 297 W4379163852.pdf 6 6 title 0.71333313 differential scanning calorimetry 297 331 W4379163852.pdf 6 7 text 0.64490896 ( 331 333 W4379163852.pdf 6 8 title 0.53640926 DSC 333 336 W4379163852.pdf 6 9 text 0.9818378 ") and powder X-ray diffraction: By identifying whether or not crystal planes are present in a solid through the geometric scattering of radiation from those planes, one can determine the degree of crystallinity of that solid. By mea- suring the temperatures at which glass and melting points are reached and the enthalpies that go along with those temperatures, DSC is a different tech- nique from that used with bulk materials that can also be used to identify the type and speciation of crystallinity present in nanoparticles [ 28] ." 336 893 W4379163852.pdf 6 10 separator 0.9965905 ¶ 893 895 W4379163852.pdf 6 11 title 0.9897611 SLN sterilization 895 913 W4379163852.pdf 6 12 separator 0.9925622 ¶ 913 915 W4379163852.pdf 6 13 text 0.9996883 "For distribution via intravenous and ocular routes, SLN must be sterile. The hot nanodroplets’ size will likely alter due to the hot o/w microemulsion that develops in the autoclave due to the maximum tem- perature at which autoclaving attained sterilization." 915 1183 W4379163852.pdf 6 14 separator 0.5054388 1183 1184 W4379163852.pdf 6 15 text 0.99520683 "¶ After a subsequent progressive cooling, the SLN was reconstructed; nevertheless, certain nanodroplets may mix to form more signiβicantly than the origi- nal SLN. Because SLN were rinsed before steriliza- tion, there may be less. In the hot system, surfac- tants and co-surfactants could improperly stabilize the nanodroplets." 1184 1523 W4379163852.pdf 6 16 separator 0.9963505 ¶ 1523 1525 W4379163852.pdf 6 17 title 0.99029255 Formulations based on oral lipid [ 29] 1525 1564 W4379163852.pdf 6 18 separator 0.99439365 ¶ 1564 1566 W4379163852.pdf 6 19 text 0.99929863 "Among the advantages that Using lipid-based oral compositions offers are the following, The capacity of poorly water-soluble, lipophilic medications to be absorbed through the GI tract is improved, and its variability is reduced. It may be possible to minimize or do away with sev- eral stages of creation and processing, such as salt selection, drug crystalline form discovery, coat- ing, βlavour-decreased conβinement, masking, and cleanup requirements during the design of very potent or cytotoxic therapeutic products. Diminu- tion or elimination of eating’s positive beneβits." 1566 2170 W4379163852.pdf 6 20 separator 0.96232533 ¶ 2170 2172 W4379163852.pdf 6 21 text 0.9994764 "Fabrication with relatively simple, readily avail- able tools. Different oral lipid-based formula- tions include Self-emulsifying compositions, single- component lipoprotein formulations, solid disper- sion formulations, and pelletizing melt." 2172 2423 W4379163852.pdf 6 22 separator 0.8942697 ¶ 2423 2425 W4379163852.pdf 6 23 text 0.9968303 "The most widely used To create oral lipid- based compositions, excipients were found to be moderate- but rather lengthy triglyceride-based nutritional oil, such as coconut or palm seed oil, as well as lipophilic solvents, such as propylene, alco-hol, as well as polyethylene glycol 400, and glycerin, as well as a variety of pharmaceutically acceptable surfactants like Cremophor® EL and RH40. When Standard techniques (solid dry or wet granulated, either water-miscible solutions in such capsules) did not produce enough bioavailability or when the medication was an oil, these formulations were used (dronabinol, ethyl icosapentate, indometacin farnesol, teprenone, and tocopherol nicotinate). These formulations were available as liquid-βilled hard or soft capsules, bulk oral solutions, or both." 2425 3253 W4379163852.pdf 6 24 separator 0.75045246 ¶ 3253 3255 W4379163852.pdf 6 25 text 0.9992815 "These formulations range in complexity from straightforward drug strategies for multi-excipient, self-emulsifying pharmaceutical delivery systems using nutritive oils, with total daily medication dosages ranging from less than 0.25 g to more than 2000 mg (SEDDS)." 3255 3529 W4379163852.pdf 6 26 separator 0.8173895 ¶ 3529 3531 W4379163852.pdf 6 27 text 0.9995951 "The medication content of unit-dose capsule prod- ucts ranges from 0.25 g to 500 mg, whereas that of oral solution solutions ranges from 1 g/ml to 100 mg/ml. In a capsule formulation, the total amount of lipid excipient delivered in a single dose ranges from 0.5 to 5 g. In contrast, the amount for oral solution solutions might range from 0.1 to 20 ml. Several of these goods can only be kept at room temperature brieβly. It must be held at 2-8◦for lengthy periods due to chemical and physical stability concerns." 3531 4066 W4379163852.pdf 6 28 separator 0.9963834 ¶ 4066 4068 W4379163852.pdf 6 29 title 0.988351 "Administrative strategies and their biodistribu- tion" 4068 4124 W4379163852.pdf 6 30 separator 0.9934975 ¶ 4124 4126 W4379163852.pdf 6 31 text 0.99975437 "SLN comprises lipids or waxes that are signiβicant to or associated with biology. A solid lipid nanopar- ticle’s in vivo course will be determined through signiβicantly inβluenced based on the administra- tion and distribution routes mechanism (biological material adsorbs onto nanoparticle surface whereas SLN components deabsorb through into the physi- cal environment). As a result, the carrier’s in vivo fate may be signiβicantly inβluenced by the body’s metabolic and transport routes. The most critical SLN breakdown enzymes are probably the lipases in several organs and tissues. Lipases break the ester bond to produce free fatty acids, glycerol, and par- tial linoleic acid. Most lipases require an oil/water contact to activate their catalytic core (lid opening)." 4126 4928 W4379163852.pdf 6 32 separator 0.7714288 ¶ 4928 4930 W4379163852.pdf 6 33 text 0.9995523 "An in vitro experiment revealed that the properties of solid lipid nanoparticles (lipid matrix, stabilizing surfactant) inβluence how quickly pancreatic lipase breaks them down." 4930 5114 W4379163852.pdf 6 34 separator 0.9707969 ¶ 5114 5116 W4379163852.pdf 6 35 text 0.99905807 "Per-oral administration: Two possibilities for SLN that can be consumed orally are aqueous disper- sions and conventional dosage forms like tablets, pellets, or capsules βilled with SLN. The high ionic strength and acidity of the stomach promote particle aggregation. Although, To our knowledge, no experi- ©" 5116 5437 W4379163852.pdf 6 36 paratext 0.9769422 Pharma Springs Publication jInternational Journal of Experimental and Biomedical Research 23 5437 5530 W4379163852.pdf 6 0 paratext 0.9790689 "ISSN: 2320 -5407 Int. J. Adv. Res. 6(10), 1072 -1076 1075" 0 138 W2901908662.pdf 3 1 separator 0.93847215 ¶ ¶ 140 147 W2901908662.pdf 3 2 caption 0.99649584 "Figure 2: -Malonaldehyde levels in healthy (G1,G2) and patient (G3,G4) individuals at (p<0.05). G1 control, G2, related, G3, treated, G4 untreated." 147 298 W2901908662.pdf 3 3 separator 0.9923453 ¶ ¶ 300 306 W2901908662.pdf 3 4 title 0.97112036 Discussion :- 306 320 W2901908662.pdf 3 5 separator 0.9927286 ¶ 321 323 W2901908662.pdf 3 6 text 0.99807495 "The role of free radicals, oxidative stress, and lipid peroxidation in carcinogenesis and their contribution to the initiation and progression of the process are well documented(9). In recent years, using MDA as a marker of oxidative stress, there has been a growing interest in studying the role played by lipid peroxidation in cancer progression. MDA is low - molecularweightaldehydethatcanbeproducedfromfree radical attack on polyunsaturated fatty acids. Increased plasma MDA levels have been reported in breas t cancer(10). Our results showed increase in MDA level in breast cancer as compared to controls thus agreeing with the previous studies, and thus suggesting increased lipidperoxidation in breast cancer patients. ¶ Presentationofnitricoxideinhumanserumisawell - known phenomenon that points to a crucial role of nitric oxide in physiological and pathological processes. It exhibits adualrole,withregard tothe complexmechanism of tumor invasion and metastasis. It could either mediate tumorocidal activity or promote tumor growth(11).Its presence has been assessed in various humanmalignanttumors(12).Some workers have reported a higher NO syntheses activity in tumors(12), while some have reported a lower activity(13). Our results support the general observation thatbreastmalignanciesareassociatedwithanincreased level of nitric oxide. In this study, we demonstrated that serumlevelsofnitricoxidearesignificantlyincreasedin breast cancer as compared to healthy subject. Increased NO in serum of breast carcinoma may be in response of inflammation(14). ¶ Considering the data presented in this study, we suggest that free radicals induce lipid peroxidation and peroxidation of unsaturated fatty acid with decreased activity of enzymatic antioxi dants in breast cancer; and NO may be increased in response to inflammation(15). However, studies with more patients and parameters related to oxidative stress, lipid profile, and antioxidants statusarerequired,toexploretheassociationamongthem, in relation to breast cancer patients and healthycontrols(16)." 323 2454 W2901908662.pdf 3 7 separator 0.8075099 ¶ ¶ 2455 2461 W2901908662.pdf 3 8 title 0.8387883 Conclusions :- 2461 2476 W2901908662.pdf 3 9 separator 0.98139405 ¶ 2477 2479 W2901908662.pdf 3 10 text 0.9996338 "In the present study, Malondialdehyde (MDA) and nitric oxide (NO) level has been consistently demonstrated to be elevated in patients with breast cancer. Increase the effectiveness of (MDA, NO) in breast cancer leads to oxidative damage, tissue damage." 2479 2739 W2901908662.pdf 3 11 separator 0.9940454 ¶ 2741 2743 W2901908662.pdf 3 0 paratext 0.97503585 M. HASHEMPOUR, Z. PAKDAMAN AND M. DOOSTPARAST 465 0 49 W3033009670.pdf 3 1 separator 0.99412465 ¶ 49 51 W3033009670.pdf 3 2 text 0.9883258 Under the LTCPHR with the one-parameter exponential baseline DF, we have 51 124 W3033009670.pdf 3 3 separator 0.7374135 ¶ 124 126 W3033009670.pdf 3 4 math 0.87926495 "Qi:=r∑ j=1(n−j+ 1)jaD ij∼Γ(r; i); i= 1;· · ·; s; (8)" 126 182 W3033009670.pdf 3 5 text 0.8871719 ¶ where Γ(m; n )calls for the gamma distribution with the shape and the scale parameters mandn, respectively. 182 292 W3033009670.pdf 3 6 separator 0.9345964 ¶ 292 294 W3033009670.pdf 3 7 text 0.96059704 "From Equation ( 8) and for i= 1;· · ·; s,ˆi∼Γ(r; i=r), and then E(ˆi) =iandV ar(ˆi) =2 i=r. Notice that the ML estimate ˆ0in Equation ( 6) is the arithmetic mean of the ML estimates ˆifor the mean populations given by Equation ( 7), i.e. ˆ0=∑s" 294 553 W3033009670.pdf 3 8 separator 0.805861 ¶ 553 555 W3033009670.pdf 3 9 math 0.9420159 "i=1ˆi=s:So,E(ˆ0) = ̄andV ar(ˆ0) =2=srwhere ̄=∑s i=1i=sand 2=∑s i=12 i=s." 555 645 W3033009670.pdf 3 10 separator 0.9947953 ¶ 645 647 W3033009670.pdf 3 11 title 0.987531 Case II: The parameter ais unknown 647 682 W3033009670.pdf 3 12 separator 0.9952358 ¶ 682 684 W3033009670.pdf 3 13 text 0.99711376 "Suppose that the parameter ain Equation ( 5) is unknown. In this case, calculations are complicated. The logarithm of LF in Equation ( 5) can be written as" 684 842 W3033009670.pdf 3 14 separator 0.8272217 ¶ 842 844 W3033009670.pdf 3 15 math 0.95605713 "l(1;· · ·; s; a;x) =rslna−rs∑ i=1lni−as∑ i=1r∑ j=1j(n−j+ 1)Dij i: (9)" 844 926 W3033009670.pdf 3 16 separator 0.97716653 ¶ 926 928 W3033009670.pdf 3 17 text 0.9943967 "The ML estimates of the parameters which are shown by ˆˆiand ˆafori= 1; : : : ; s , (if exist) are obtained (numerically) by solving the following likelihood equations:" 928 1100 W3033009670.pdf 3 18 separator 0.94515544 ¶ 1100 1102 W3033009670.pdf 3 19 math 0.9484149 "@l @a=rs a−s∑ i=1r∑ j=1j(n−j+ 1)Dij i= 0; (10) and @l @k=a 2 kr∑ j=1j(n−j+ 1)Dkj−r k= 0; k = 1; : : : ; s: (11)" 1102 1242 W3033009670.pdf 3 20 separator 0.96235573 ¶ 1242 1244 W3033009670.pdf 3 21 text 0.9846004 From Equations ( 10) and ( 11), we have 1244 1284 W3033009670.pdf 3 22 separator 0.76732856 ¶ 1284 1286 W3033009670.pdf 3 23 math 0.9590082 "ˆa(1; : : : ; k−1; k+1; : : : ; s) =r(s−1) s∑ i=1i̸=kr∑ j=1j(n−j+1)Dij σi; (12) and ˆˆk(1; : : : ; k−1; k+1; : : : ; s) =(s−1)r∑ j=1j(n−j+ 1)Dkj s∑ i=1i̸=kr∑ j=1j(n−j+1)Dij σi; k = 1; : : : ; s: (13)" 1286 1521 W3033009670.pdf 3 24 separator 0.98809636 ¶ 1521 1523 W3033009670.pdf 3 25 text 0.9705389 "Equations ( 12) and ( 13) cannot be solved analytically. The matrix of second derivatives of the likelihood with respect to the parameters is called Hessian matrix ( HM), that is HM = [[(@2log(L)=" 1523 1722 W3033009670.pdf 3 26 math 0.561742 @ i@j 1722 1729 W3033009670.pdf 3 27 text 0.57961893 )1≤i 1729 1733 W3033009670.pdf 3 28 math 0.5042468 , 1733 1734 W3033009670.pdf 3 29 text 0.8477004 "j≤s+1]], where i=i;(1≤i; j≤s)andi=a;(i; j=s+ 1). For more information, see Khuri [ 17]. After some algebraic calculations, we have" 1734 1871 W3033009670.pdf 3 30 separator 0.74224305 ¶ 1871 1873 W3033009670.pdf 3 31 math 0.8549837 "HM =( B11B12 B21B22) ; (14)" 1873 1907 W3033009670.pdf 3 32 separator 0.9915042 ¶ 1907 1909 W3033009670.pdf 3 33 paratext 0.9691648 Stat., Optim. Inf. Comput. Vol.8, June 2020 1909 1953 W3033009670.pdf 3 0 paratext 0.98905 1291Cadernos de Prospecção, Salvador, v. 16, n. 4, Edição Prospect, p. 1274-1291, maio de 2023. 0 95 W4378472965.pdf 17 1 title 0.98737586 Mapeamento de Tecnologias Direcionadas para a Prevenção de Lesão por Pressão Alinhadas às Diretrizes Internacionais 95 210 W4378472965.pdf 17 2 separator 0.99308777 ¶ 210 212 W4378472965.pdf 17 3 title 0.88671815 Apêndice – International Patent Classiication (IPC) 212 264 W4378472965.pdf 17 4 separator 0.9852276 ¶ 264 266 W4378472965.pdf 17 5 title 0.85779697 Tabela 1 – Códigos IPCs usados na metodologia 266 312 W4378472965.pdf 17 6 separator 0.98223495 ¶ 312 314 W4378472965.pdf 17 7 table 0.87362486 Código iPC definição 314 336 W4378472965.pdf 17 8 separator 0.8463652 ¶ 336 338 W4378472965.pdf 17 9 table 0.92573816 "A41B-009/12Roupas de baixo protetoras combinadas com enchimentos ou almofadas absorventes ou especialmente adaptadas para segurá-las A41D-013/12 Aventais ou camisolas para cirurgiões ou pacientes A61F-005/34Almofadas de compressão cheias de ar ou líquido [válvulas especialmente adaptadas para usos médicos]" 338 656 W4378472965.pdf 17 10 separator 0.8664025 ¶ 656 658 W4378472965.pdf 17 11 table 0.9189418 "A61G-005/00Cadeiras ou transportes pessoais especialmente adaptados para pacientes ou deficientes físicos, p. ex. cadeiras de rodas" 658 793 W4378472965.pdf 17 12 separator 0.8228706 ¶ 793 795 W4378472965.pdf 17 13 table 0.87110263 "A61G-007/00Camas especialmente adaptadas para enfermagem; dispositivos para levantamento de pacientes ou deficientes físicos" 795 923 W4378472965.pdf 17 14 separator 0.84107363 ¶ 923 925 W4378472965.pdf 17 15 table 0.86718994 "A61G-007/002Camas especialmente adaptadas para enfermagem; dispositivos para levantamento de pacientes ou deficientes físicos com estrutura de colchão ajustável " 925 1090 W4378472965.pdf 17 16 separator 0.5369498 ¶ 1090 1091 W4378472965.pdf 17 17 table 0.7874573 "A61G-007/015Camas especialmente adaptadas para enfermagem; dispositivos para levantamento de pacientes ou deficientes físicos com estrutura de colchão ajustável dividida em diferentes seções" 1091 1288 W4378472965.pdf 17 18 text 0.49686667 ajust 1288 1294 W4378472965.pdf 17 19 table 0.5270993 áveis 1294 1299 W4378472965.pdf 17 20 text 0.55938965 ", p. ex. para a posição ""Gatch" 1299 1329 W4378472965.pdf 17 21 table 0.53224903 """" 1329 1330 W4378472965.pdf 17 22 separator 0.7540035 ¶ 1330 1332 W4378472965.pdf 17 23 table 0.7385946 "A61G-007/057Camas especialmente adaptadas para enfermagem; dispositivos para levantamento de pacientes ou deficientes físicos com disposições para evitar dores no leito ou para apoiar pacientes com queimaduras, p. ex. colchões" 1332 1565 W4378472965.pdf 17 24 text 0.50875735 especialmente adaptados para esse fim 1565 1603 W4378472965.pdf 17 25 separator 0.9474836 ¶ 1603 1605 W4378472965.pdf 17 26 table 0.85574275 "A43B-003/00 Calçados caracterizados pelo formato ou o uso A43B-007/08Calçados com dispositivos higiênicos ou sanitários com orifícios de ventilação, com ou sem fechos A43B-007/20Calçados com dispositivos higiênicos ou sanitários com elementos para suportar ou firmar tornozelos" 1605 1893 W4378472965.pdf 17 27 separator 0.5820856 ¶ 1893 1895 W4378472965.pdf 17 28 table 0.7418424 "A61F-005/01Dispositivos ortopédicos, p. ex. dispositivos de mobilização a longo prazo ou de pressionamento direto para o tratamento de ossos quebrados ou deformados tais como talas, moldes ou suportes" 1895 2102 W4378472965.pdf 17 29 separator 0.57562673 ¶ 2102 2104 W4378472965.pdf 17 30 table 0.93418276 "A61G-007/075 Descansos especialmente adaptados para os membros A61F-013 Ataduras, curativos ou almofadas absorventes A61Q Uso específico de cosméticos ou preparações similares para higiene pessoal A61K Preparações para finalidades médicas, odontológicas ou higiênicas" 2104 2378 W4378472965.pdf 17 0 paratext 0.97430056 48 0 2 W3173465226.pdf 47 1 separator 0.9883146 ¶ ¶ 4 10 W3173465226.pdf 47 2 caption 0.99265945 "Figure S7. Structural basis of promoter -sequence dependence of primer -dependent initiation at position TSS -2" 10 127 W3173465226.pdf 47 3 separator 0.748525 ¶ 128 130 W3173465226.pdf 47 4 caption 0.99263656 Crystal structure of T. thermophilus RPo[T TSS-2CTSS-1CTSS]-GpG -CMPcPP 130 203 W3173465226.pdf 47 5 separator 0.98380697 ¶ 205 207 W3173465226.pdf 47 6 caption 0.9643763 A. Experimental electron density (contoured at 2.5s; green mesh) and atomic model for DNA template 207 309 W3173465226.pdf 47 7 separator 0.49798286 ¶ 309 310 W3173465226.pdf 47 8 caption 0.9665861 "strand (yellow, red, blue, and orange for C, O, N, and P atoms), dinucleotide primer (green, red, blue, and orange for C, O, N, and P atoms), RNAP active -center catalytic Mg2+(I) (violet sphere), and RNAP bridge helix (gray ribbon)." 310 550 W3173465226.pdf 47 9 separator 0.9013908 ¶ 552 554 W3173465226.pdf 47 10 caption 0.96546406 B. Contact s of RNAP residues (gray, red, and blue for C, O, and N atoms) with primer and RNAP 554 651 W3173465226.pdf 47 11 separator 0.5526246 ¶ 652 654 W3173465226.pdf 47 12 caption 0.93293333 "active -center catalytic Mg2+(I). RNAP residues are numbered both as in T. thermophilus RNAP and as in E. coli RNAP (in parentheses)." 654 791 W3173465226.pdf 47 13 separator 0.8541251 ¶ 793 796 W3173465226.pdf 47 14 paratext 0.87646085 . CC-BY 4.0 International license available under awas not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint (which this version posted April 7, 2021. ; https://doi.org/10.1101/2021.04.06.438613doi: bioRxiv preprint 796 1132 W3173465226.pdf 47 0 paratext 0.98056453 "Vol.:(0123456789)1 3Journal of Neuro-Oncology (2019) 141:467–473 https://doi.org/10.1007/s11060-018-03057-z" 0 110 W2903060807.pdf 0 1 separator 0.9888102 ¶ 110 112 W2903060807.pdf 0 2 title 0.99186265 CLINICAL STUDY 112 127 W2903060807.pdf 0 3 separator 0.9869144 ¶ 127 129 W2903060807.pdf 0 4 title 0.69318366 Increased compliance with tumor treating fields therapy is prognostic 129 201 W2903060807.pdf 0 5 text 0.48925957 ¶ 201 202 W2903060807.pdf 0 6 title 0.6171232 for improved survival in the 202 231 W2903060807.pdf 0 7 text 0.6152487 treatment 231 241 W2903060807.pdf 0 8 title 0.6628318 of glioblastoma: 241 259 W2903060807.pdf 0 9 text 0.5043644 a 259 260 W2903060807.pdf 0 10 title 0.6497407 subgroup analysis of the EF-14 phase III trial 260 307 W2903060807.pdf 0 11 separator 0.992871 ¶ 307 309 W2903060807.pdf 0 12 contact 0.62589353 S. A. Toms1 · C. Y . Kim2 · G. Nicholas3 · Z. Ram4 309 361 W2903060807.pdf 0 13 separator 0.905435 ¶ 361 363 W2903060807.pdf 0 14 paratext 0.965365 "Received: 30 August 2018 / Accepted: 21 November 2018 / Published online: 1 December 2018 © The Author(s) 2018" 363 477 W2903060807.pdf 0 15 separator 0.9912859 ¶ 477 479 W2903060807.pdf 0 16 title 0.9451563 Abstract 479 488 W2903060807.pdf 0 17 separator 0.9930959 ¶ 488 490 W2903060807.pdf 0 18 text 0.99936473 "Background Tumor treating fields (TTFields) is a non-invasive, antimitotic therapy. In the EF-14 phase 3 trial in newly diagnosed glioblastoma, TTFields plus temozolomide (TTFields/TMZ) improved progression free (PFS) and overall survival (OS) versus TMZ alone. Previous data indicate a ≥ 75% daily compliance improves outcomes. We analyzed compliance data from TTFields/TMZ patients in the EF-14 study to correlate TTFields compliance with PFS and OS and identify potential lower boundary for compliance with improved clinical outcomes.Methods Compliance was assessed by usage data from the NovoTTF-100A device and calculated as percentage per month of TTFields delivery. TTFields/TMZ patients were segregated into subgroups by percent monthly compliance. A Cox pro-portional hazard model controlled for sex, extent of resection, MGMT methylation status, age, region, and performance status was used to investigate the effect of compliance on PFS and OS.Results A threshold value of 50% compliance with TTFields/TMZ improved PFS (HR 0.70, 95% CI 0.47–1.05) and OS (HR 0.67, 95% CI 0.45–0.99) versus TMZ alone with improved outcome as compliance increased. At compliance > 90%, median survival was 24.9 months (28.7 months from diagnosis) and 5-year survival rate was 29.3%. Compliance was independent of gender, extent of resection, MGMT methylation status, age, region and performance status (HR 0.78; p = 0.031; OS at compliance ≥ 75% vs. < 75%).Conclusion A compliance threshold of 50% with TTFields/TMZ correlated with significantly improved OS and PFS versus TMZ alone. Patients with compliance > 90% showed extended median and 5-year survival rates. Increased compliance with TTFields therapy is independently prognostic for improved survival in glioblastoma." 490 2282 W2903060807.pdf 0 19 separator 0.9972644 ¶ 2282 2284 W2903060807.pdf 0 20 title 0.88690555 Keywords 2284 2293 W2903060807.pdf 0 21 table 0.6513659 Glioblastoma · Tumor treating fields · Compliance · Monthly usage 2293 2359 W2903060807.pdf 0 22 separator 0.9962058 ¶ 2359 2361 W2903060807.pdf 0 23 title 0.9437688 Introduction 2361 2374 W2903060807.pdf 0 24 separator 0.99227536 ¶ 2374 2376 W2903060807.pdf 0 25 text 0.996443 "Glioblastoma (GBM) is the most common and aggressive adult brain tumor, accounting for 56% of all gliomas and 15% of all primary brain tumors with an annual incidence in the United States that increases with age—ranging from 0.2 per 100,000 in 0–19 year old population to the highest rate of 15.3 per 100,000 in the 75–84 year old population [1]. Glioblastoma remains incurable with a median survival of only 15 months until recently [2 ]. The previous standard treatments for newly diagnosed GBM include maximally safe surgical resection followed by radiation therapy (RT) and adjuvant temozolomide (TMZ) chemotherapy [3 ]. Tumor treating fields (TTFields) are a unique treatment modality [4 , 5] for GBM that affects rapidly dividing gli- oma cells through the action of low-intensity, intermediate" 2376 3193 W2903060807.pdf 0 26 separator 0.9827572 ¶ 3194 3196 W2903060807.pdf 0 27 paratext 0.9111896 "Electronic supplementary material The online version of this article (https ://doi.org/10.1007/s1106 0-018-03057 -z) contains supplementary material, which is available to authorized users." 3196 3392 W2903060807.pdf 0 28 separator 0.9175499 ¶ 3392 3394 W2903060807.pdf 0 29 contact 0.9950838 "* S. A. Toms Steven.Toms@Lifespan.org" 3395 3437 W2903060807.pdf 0 30 separator 0.8716132 ¶ 3437 3439 W2903060807.pdf 0 31 contact 0.99011314 "1 Department of Neurosurgery, Warren Alpert Medical School of Brown University, Providence, RI, USA 2 Seoul National University, Bundang, South Korea 3 Ottawa Hospital Research Institute, Ottawa, ON, Canada 4 Tel Aviv Medical Center, Tel Aviv, Israel" 3439 3699 W2903060807.pdf 0 0 paratext 0.83262867 "121Rio de Janeiro, v. 38, n. 2, 2002 Jornal Brasileiro de Patologia e Medicina Laboratorialárea salientaram com exatidão os três sintomas habituais da doença." 0 160 W2059064090.pdf 2 1 separator 0.99285 ¶ 160 162 W2059064090.pdf 2 2 text 0.9996232 "Muitos (60,2%) acreditam que um exame para- sitológico de fezes de rotina inclui pesquisa de oocistosdo Cryptosporidium parvum . Entre as especialidades, 83% dos infectologistas solicitariam algum exame caso suspei- tassem da doença. Entretanto somente 21,9% dos inter-nistas, 37,5% dos gastroenterologistas, 33,3% dos pedia- tras, 37,5% dos médicos comunitários e 42,8% dos ginecologistas obstetras solicitariam algum teste específi-co se suspeitassem da doença. As principais razões para não solicitarem testes laboratoriais específicos foram: bai- xa ocorrência da doença (23,8%), falta de familiaridadecom a doença (14,7%), falta de conhecimento dos testes (12,5%) e custo elevado dos mesmos (4,5%)." 162 882 W2059064090.pdf 2 3 separator 0.95344365 ¶ 882 884 W2059064090.pdf 2 4 text 0.9994784 "A maioria dos entrevistados (94,3%) acha que precisa de mais informações sobre o tema. Por especialidade, 97,5% dos internistas, 72,7% dos gastroenterologistas, 33,3% dos infectologistas, 100% dos pediatras e médicoscomunitários e 87,5% dos ginecologistas obstetras acham que necessitam conhecer melhor a doença." 884 1205 W2059064090.pdf 2 5 separator 0.9960686 ¶ 1205 1207 W2059064090.pdf 2 6 title 0.9873003 Discussão 1207 1217 W2059064090.pdf 2 7 separator 0.9962802 ¶ 1217 1219 W2059064090.pdf 2 8 text 0.99972975 "Os resultados deste estudo mostram que a maioria dos médicos entrevistados, atuantes em hospitais universitáriosde Porto Alegre, sabe que criptosporidiose intestinal mani- festa-se com diarréia aquosa prolongada, especialmente em pacientes imunodeprimidos. No entanto não reconhecemoutros sintomas da doença, como dor abdominal e náuseas/ vômitos, nem outros grupos de risco, tais como crianças em creches e pessoas em contato com animais. A diarréia aquo- sa prolongada é aceita como sintoma da doença por 62,5% dos médicos comunitários e 38,8% dos pediatras, e tam- bém 62,5% e, principalmente, 44,4% destes especialistas,respectivamente, não reconhecem crianças em creches como grupo em risco, apesar de, atualmente, as crianças de dife- rentes classes socioeconômicas permanecerem nestes esta-belecimentos grande parte de seu dia. Assim, a doença pode estar sendo subestimada, especialmente em crianças." 1219 2150 W2059064090.pdf 2 9 separator 0.98057675 ¶ 2150 2152 W2059064090.pdf 2 10 text 0.9996845 "Mesmo quando há suspeita diagnóstica correta da doença podem ocorrer falhas no processo. Muitas vezes isso acontece pelo desconhecimento dos testes laboratoriais re- lativos à doença. A maioria dos entrevistados (60,2%) achaque os laboratórios são capazes de detectar o parasita emum exame parasitológico de fezes de rotina, sem requisiçãomédica para a sua procura específica. Na verdade, nenhumlaboratório realiza a procura do parasita se esta não for re-quisitada pelo médico assistente. A identificação laboratorial é importante, não somente para que o diagnóstico seja esta-belecido, mas também para que dados epidemiológicos eprogramas de saúde pública possam ser ajustados, principal-mente se levarmos em conta que o parasito é consideradoum problema de saúde pública não só nos países subdesen-volvidos, como nos desenvolvidos também (17)." 2152 3007 W2059064090.pdf 2 11 separator 0.9847583 ¶ 3007 3009 W2059064090.pdf 2 12 text 0.99971956 "A razão mais freqüente apontada para a não-realização de testes laboratoriais, como o diagnóstico de criptosporidioseintestinal, foi a baixa ocorrência da doença. A maioria dosestudos de prevalência é limitada a populações selecionadas,como pacientes imunodeprimidos, crianças em creches,crianças hospitalizadas ou agricultores (6, 8-10, 14). Entre-tanto a prevalência real da doença na população geral é des-conhecida. Alguns trabalhos (11, 12) têm mostradoprevalência de 1% em amostras aleatórias de fezes na popu-lação geral, e o mesmo índice aparece em estudo só comcrianças (15). Um estudo realizado em Connecticut, EstadosUnidos, mostrou altos valores de positividade nas amostras(13), ou seja, 2,8%, quando o exame específico foi solicita-do. Entretanto todas as amostras suspeitas de criptosporidioseforam examinadas, independente de solicitação médica, eforam positivas em 5,8% dos casos. Conclui-se que os pacien-tes com alto risco de serem contaminados com a doençanão estão sendo bem selecionados para a realização de tes-tes laboratoriais. Isto pode ocorrer pelo fato de os médicosdesconhecerem a necessidade de requisição do exame espe-cífico para o parasita." 3009 4185 W2059064090.pdf 2 13 separator 0.9965042 ¶ 4185 4187 W2059064090.pdf 2 14 title 0.9909403 Conclusão 4187 4197 W2059064090.pdf 2 15 separator 0.99626523 ¶ 4197 4199 W2059064090.pdf 2 16 text 0.9997084 "É iminente a necessidade de melhora do conhecimen- to médico sobre criptosporidiose em nosso meio. Médi- cos de todas as especialidades, mas sobretudo aqueles li-gados a populações de risco (médicos comunitários e pedia tras), têm poucas informações sobre a apresentação e os fatores de risco da doença. Em quase todas as especi-alidades é pequeno o conhecimento sobre a necessidade de solicitar a pesquisa específica do parasita no exame parasi- tológico de fezes. Assim corremos o risco de subestimar apresença da doença entre nós e, com isso, o impacto que ela exerce sobre a saúde pública, principalmente se levar- mos em consideração, como citado anteriormente, que oproblema ocorre não somente em países subdesenvolvi- dos, mas nos desenvolvidos também (17)." 4199 4982 W2059064090.pdf 2 17 separator 0.97240615 ¶ 4982 4984 W2059064090.pdf 2 18 text 0.99280155 "Indubitável é a preocupação dos médicos entrevista- dos com a doença, pois a maioria se mostrou interessada em receber maiores informações sobre a mesma.Wiebbelling et al." 4984 5160 W2059064090.pdf 2 19 title 0.4165903 Avaliação 5160 5170 W2059064090.pdf 2 20 bibliography 0.48874548 do conhecimento sobre criptosporidiose em uma amostra de médicos de 5170 5238 W2059064090.pdf 2 21 title 0.41034803 Porto A 5238 5246 W2059064090.pdf 2 22 bibliography 0.46797013 legre 5246 5251 W2059064090.pdf 2 23 title 0.38614652 , 5251 5252 W2059064090.pdf 2 24 bibliography 0.33682021 RS 5252 5255 W2059064090.pdf 2 0 paratext 0.98508346 56 Jin. 0. v. a. peel and others ox [Jan. 23, 0 55 W2139215633.pdf 1 1 separator 0.9951231 ¶ 55 57 W2139215633.pdf 1 2 text 0.97436595 "The subspecies nigrimamts was based upon a single example from Mombasa (see Proc. Zool. Soc. 1890, p. 130, pi. xiv. fig. 2)." 57 204 W2139215633.pdf 1 3 separator 0.7919019 ¶ 204 206 W2139215633.pdf 1 4 text 0.99109894 "U.jlavimanus is based upou a specimen in the British Museum obtained by Mr. J. Wilson at Mombasa in British East Africa." 206 348 W2139215633.pdf 1 5 separator 0.8036644 ¶ 348 350 W2139215633.pdf 1 6 text 0.99876744 "It is interesting to note tbat tbe two subspecies most distinct from each other, namely, U. f. Jlavimanus and U. f. nigrimanus, occur iu the same locality, whei'eas the subspecies intermediate between them is found elsewhere." 350 614 W2139215633.pdf 1 7 separator 0.9960761 ¶ 614 616 W2139215633.pdf 1 8 title 0.73451096 Genus Pababuthus 616 634 W2139215633.pdf 1 9 bibliography 0.4550681 Po 635 638 W2139215633.pdf 1 10 title 0.41670072 cock 638 642 W2139215633.pdf 1 11 bibliography 0.6428199 . 642 643 W2139215633.pdf 1 12 separator 0.87450546 ¶ 643 645 W2139215633.pdf 1 13 bibliography 0.9912727 "Pababuthus gbanimanus Pocock. Parabuthus granimus, Pocock, Journ. Linn. Soc, Zool. xxv. p. 311 (1»95)." 645 763 W2139215633.pdf 1 14 separator 0.9729959 ¶ 763 765 W2139215633.pdf 1 15 bibliography 0.9895127 "Loc. Zeyla in North-west Somaliland (E. W. Oates), Goolis Mountains (Lort Phillips). In tbe British Museum." 765 889 W2139215633.pdf 1 16 separator 0.9840518 ¶ 889 891 W2139215633.pdf 1 17 bibliography 0.97719806 "Pababuthus heteburus Pocock. Parabuthus heterurus, Pocock, in Donaldson Smith's ' Through Unknown African Countries,' p. 4(J2 (1897)." 891 1043 W2139215633.pdf 1 18 separator 0.9762188 ¶ 1043 1045 W2139215633.pdf 1 19 bibliography 0.98997843 "Loc. Hargaisa, Silul, Shebeli Eiver (A. Donaldson Smith) ; Goolis Mountains (E. Lort Phillips). In British Museum." 1045 1177 W2139215633.pdf 1 20 separator 0.994745 ¶ 1177 1179 W2139215633.pdf 1 21 text 0.9871845 The two species of this genus may be recognized as follows : — 1179 1254 W2139215633.pdf 1 22 separator 0.49929628 1254 1255 W2139215633.pdf 1 23 text 0.94335705 "¶ a. Hand and brachium closely granular ; 5th segment of tail strongly int'uscate at leust below P. graninianus. b. Hand and brachium smooth, punctured, hairy ; 5th caudal segment clear yellow throughout, 4th segment and vesicle black P. heterwus." 1255 1538 W2139215633.pdf 1 24 separator 0.9938582 ¶ 1538 1540 W2139215633.pdf 1 25 title 0.7326878 Genus Buthus Leach. 1540 1562 W2139215633.pdf 1 26 separator 0.9718772 ¶ 1562 1564 W2139215633.pdf 1 27 text 0.89878595 Buthus occitanus (Amoreux), subsp. now bebbebensis. 1564 1621 W2139215633.pdf 1 28 separator 0.9176974 ¶ 1621 1623 W2139215633.pdf 1 29 text 0.9914739 "Colour yellow, with black lines along the keels of the upperside of the trunk, humerus, brachium, and hand, also the distal half of the femora infuscate and the base and keels on the patella?. Body and tail crested and granular as in the typical form, the granules of the inferior keels of the 2nd and 3rd caudal segments about as much enlarged as in the Spanish form ; external surface of hand with a few granules, a pair of strong granular finger-keels running along its upperside and inner edge." 1623 2217 W2139215633.pdf 1 30 separator 0.9637979 ¶ 2217 2219 W2139215633.pdf 1 31 table 0.621964 Total length 38 mm. 2219 2242 W2139215633.pdf 1 32 separator 0.98865235 ¶ 2242 2244 W2139215633.pdf 1 33 bibliography 0.9462259 Somaliland (Miss Gillett). In British Museum. 2244 2295 W2139215633.pdf 1 34 separator 0.9941321 ¶ 2295 2297 W2139215633.pdf 1 35 title 0.91183645 Subsp. nov. ZETLENSIS. 2297 2322 W2139215633.pdf 1 36 separator 0.98821783 ¶ 2322 2324 W2139215633.pdf 1 37 text 0.9206028 "Colour a uniform reddish yellow, the appendages aud tail clearer than the trunk. Frontal intercarinal area of carapace covered with granules ; a median row of granules running along" 2324 2536 W2139215633.pdf 1 38 separator 0.8820997 ¶ 2536 2538 W2139215633.pdf 1 0 paratext 0.97169566 Open Peer Review on Qeios 0 25 W4252902931.pdf 0 1 separator 0.8275291 ¶ 25 27 W4252902931.pdf 0 2 paratext 0.85206056 Open Peer Review on Qeios 27 53 W4252902931.pdf 0 3 separator 0.9562259 ¶ 53 55 W4252902931.pdf 0 4 title 0.9715495 Tracheoarterial Fistula 55 79 W4252902931.pdf 0 5 separator 0.97317207 ¶ 79 81 W4252902931.pdf 0 6 title 0.6430916 National Cancer Institute 81 107 W4252902931.pdf 0 7 separator 0.95215595 ¶ 107 109 W4252902931.pdf 0 8 paratext 0.6677753 Source 109 116 W4252902931.pdf 0 9 separator 0.86700165 ¶ 116 118 W4252902931.pdf 0 10 paratext 0.43408346 National Cancer Institute. 118 145 W4252902931.pdf 0 11 separator 0.97479415 ¶ 146 148 W4252902931.pdf 0 12 title 0.47470754 Tracheoarterial Fistula 148 172 W4252902931.pdf 0 13 separator 0.5251658 ¶ 172 174 W4252902931.pdf 0 14 bibliography 0.37389904 . 174 176 W4252902931.pdf 0 15 paratext 0.4459297 NCI Thesaurus 176 190 W4252902931.pdf 0 16 bibliography 0.43750373 . 190 191 W4252902931.pdf 0 17 paratext 0.39252022 Code C1278 191 202 W4252902931.pdf 0 18 bibliography 0.38151932 25. 202 205 W4252902931.pdf 0 19 separator 0.9933698 ¶ 205 207 W4252902931.pdf 0 20 text 0.79397017 An erosion through the tracheal wall into an artery. 207 260 W4252902931.pdf 0 21 separator 0.97857106 ¶ 260 262 W4252902931.pdf 0 22 paratext 0.8987593 "Qeios · Definition, February 2, 2020" 262 306 W4252902931.pdf 0 23 separator 0.6477206 ¶ 306 308 W4252902931.pdf 0 24 paratext 0.9765805 Qeios ID: ENCRS7 · https://doi.org/10.32388/ENCRS7 308 363 W4252902931.pdf 0 25 separator 0.5711473 363 364 W4252902931.pdf 0 26 paratext 0.85990787 "¶ 1 /" 364 371 W4252902931.pdf 0 27 separator 0.7883188 ¶ 1 371 375 W4252902931.pdf 0 0 paratext 0.989172 Sustainability 2019 ,11, 863 2 of 19 0 36 W2911956250.pdf 1 1 separator 0.6754509 ¶ 36 38 W2911956250.pdf 1 2 text 0.99974304 "related to climate change [ 5]. Indeed, cities represent 70% of the total emissions of CO 2caused by humans [ 6], being one of the largest contributors to climate change. In addition, cities face devastating effects from climate change. Approximately 70% of cities are already coping with the effects of climate change. Since 90% of all urban areas are coastal, the damage caused by rising sea levels is expected to increase, with some cities in developing countries being particularly vulnerable. The increase in urban energy consumption has also led to an increase in urban air pollution. According to the World Health Organization (WHO), 90% of the inhabitants of urban areas are subject to environmental pollution levels that exceed the recommended limits [7]." 38 817 W2911956250.pdf 1 3 separator 0.96370643 ¶ 817 819 W2911956250.pdf 1 4 text 0.99977434 "Biomass refers to all organic matter existing in the biosphere, whether of plant or animal origin, as well as those materials obtained through their natural or artificial transformation [ 8–10]. Biofuels derived from biomass include firewood, wood shavings, pellets, some fruit stones such as olives and avocados, as well as nutshells. Of these, cut and chopped firewood is the least processed, and is usually burned directly in domestic appliances such as stoves and boilers. The chips come from the crushing of biomass both agricultural and forest, with their size being variable depending on the manufacturing process from which they are derived, or the transformation process that they have undergone. Finally, pellets are the most elaborate biofuel, and consist of small cylinders 6 to 12 mm in diameter and 10 to 30 mm in length that are obtained by pressing biofuels with binders. Pellets are used especially in fuels with a low energy/volume ratio [ 11,12]. Fruit stones and seeds, as well as fruit husks, though used to a lesser extent than other standardized fuels such as fuelwood, wood chips and pellets, also represent an increasingly used solid biofuel. Indeed, it has been shown that mango stone, peanut shell and sunflower seed husk have a high energy potential, with a Higher Heating Value (HHV) similar to other commercialized biofuels [ 13–15]. This fact, together with the increasing worldwide production of these by-products, makes them especially attractive for thermal energy generation, as well as to reduce CO 2emissions. Biomass is present in a variety of different materials: wood, sawdust, straw, seed waste, manure, paper waste, household waste, wastewater, etc. [16]." 819 2545 W2911956250.pdf 1 5 separator 0.97082627 ¶ 2545 2547 W2911956250.pdf 1 6 text 0.9997647 "Renewable energy for heating comes either from decentralized equipment in buildings or from centralized generation and its further distribution [ 17]. Decentralized biomass boilers are an emerging technology in constant development [ 18]. Biomass is a carbon-neutral energy source, since the biomass during its growth absorbs CO 2that is then released into the atmosphere during its combustion, with a zero-net balance of CO 2emissions [ 19]. However, large amounts of thermal energy are wasted in power generation and in many manufacturing processes. Cogeneration is the most widely used technology to reuse lost heat, generating useful heat as well as electrical energy. Combined Heat and Power plants (CHP) simultaneously produce electricity and heat for use in industrial, trade or residential contexts. Industry consumes all the heat and electricity it needs, and the excess electricity is fed into the grid and is consumed mostly in the local environment [ 20,21]. On the other hand, district heating and cooling networks are a highly effective way to integrate natural resources such as industrial and agricultural biomass, while increasing energy efficiency. Distributed energy systems consist of a network of underground insulated pipes, connected to a thermal or cold heat plant, through which hot or cold water is pumped to several buildings within a district [14]." 2547 3949 W2911956250.pdf 1 7 separator 0.964581 ¶ 3949 3951 W2911956250.pdf 1 8 text 0.9997693 "Due to the wide availability of biomass worldwide, mainly because it can be obtained as a by-product of many industrial and agricultural processes, biomass represents a growing renewable energy source with high growth potential [ 22]. One of the main characteristics of biomass that makes it suitable as an energy source is that through direct combustion it can be burned in waste conversion plants to produce electricity [ 23] or in boilers to produce heat at industrial and residential levels [ 24]." 3951 4461 W2911956250.pdf 1 9 separator 0.87352204 ¶ 4461 4463 W2911956250.pdf 1 10 text 0.9997359 "However, it must be borne in mind that direct combustion of biomass is not always feasible in existing facilities, and that in many cases it is necessary to carry out physical-chemical or biological treatments to adapt it to the quality of conventional fuels. Biomass District Heating (BDH) is a very effective system for the integration of natural energy resources within urban environments, achieving on the one hand a 100% reduction in CO 2emissions compared to fossil fuels, and on the other hand an increase in energy efficiency due to the lower cost of biofuels. Biomass exists in a variety of different" 4463 5082 W2911956250.pdf 1 0 paratext 0.9599213 "¶ ¶ IJST Vol 2 No. 1 March 2023 | ISSN: 2829 -0437 (print ), ISSN: 2829 -050X (online) , Page 48-53" 1 114 W4323980435.pdf 5 1 separator 0.5526517 115 116 W4323980435.pdf 5 2 paratext 0.8911279 ¶ 53 Ariyanto 116 129 W4323980435.pdf 5 3 text 0.9516343 The simulation is divided into 2 parts, the first part is Displacement and the second is the Safety Factor 129 237 W4323980435.pdf 5 4 separator 0.6926108 ¶ 238 240 W4323980435.pdf 5 5 text 0.8823881 "simulation of water flow in the tube by entering parameter data in the form of 4.5 bar water pressure, 0.5 m/s flow rate, and 30°C water temperature. heater flow rate 1 m/s." 240 417 W4323980435.pdf 5 6 separator 0.82333463 ¶ ¶ 419 429 W4323980435.pdf 5 7 text 0.40839514 a) b) 432 443 W4323980435.pdf 5 8 separator 0.98257864 ¶ 444 446 W4323980435.pdf 5 9 caption 0.9916229 Figure 1 1. a) Von Misses Stress, b) Displacement 446 497 W4323980435.pdf 5 10 separator 0.86141944 "¶ ¶" 499 509 W4323980435.pdf 5 11 caption 0.9592248 Figure 12. Safety Factor 509 534 W4323980435.pdf 5 12 separator 0.91948885 ¶ ¶ 536 542 W4323980435.pdf 5 13 text 0.9990404 "After the simulation based on the picture above, it can be seen that the Boiler Water Tube pipe material is given a pressure of 4.5 bar or 65.267 psi and Von Mises is simulated with a maximum value of 3.444 MPa and then displacement is still below the maximum value of 0.002 mm. And for the safety factor simulation value of 75." 542 880 W4323980435.pdf 5 14 separator 0.99327034 ¶ ¶ 882 888 W4323980435.pdf 5 15 title 0.9903935 CONCLUSION AND SUGGESTIONS 888 915 W4323980435.pdf 5 16 separator 0.99621546 ¶ 917 919 W4323980435.pdf 5 17 text 0.49593613 919 920 W4323980435.pdf 5 18 title 0.6215972 Conclusion 920 930 W4323980435.pdf 5 19 separator 0.9409602 ¶ 932 934 W4323980435.pdf 5 20 text 0.99933034 "From the results of this writing several conclusions can be drawn, including the following: The Boiler Water Tube material for clove leaf distillation uses 2 types of materials, namely for the Tube itself using copper or Cooper material and for the Boiler wall using AISI 304 Stainless Steel Sheet (ss). After the simulation based on the image above, it can be seen that the Boiler Water Tube pipe material and given a pressure of 4.5 bar or 65.267 psi and simulated by Von Mises with a maximum value of 3.444 MPa then displacement is still below the maximum value of 0.00 2 mm, and for the safety factor simulation value of 75." 934 1578 W4323980435.pdf 5 21 separator 0.9894749 ¶ ¶ 1580 1586 W4323980435.pdf 5 22 title 0.98789626 Suggestion 1586 1597 W4323980435.pdf 5 23 separator 0.9925972 ¶ 1599 1601 W4323980435.pdf 5 24 text 0.9591697 "The following are suggestions for processing the watertube boiler design data, including: 1. To get maximum results and precision, it is necessary to add parameters to determine the perfo rmance of this steam boiler. 2. In the process of initiating a design, it must go through a calculation process first to reduce design errors." 1601 1948 W4323980435.pdf 5 25 separator 0.9946834 ¶ ¶ 1950 1956 W4323980435.pdf 5 26 title 0.9601763 REFERENCES 1956 1967 W4323980435.pdf 5 27 separator 0.9943949 ¶ 1969 1971 W4323980435.pdf 5 28 bibliography 0.9915028 "[1] Ike Ridha Rusnani, 2012, Pengaruh Pemotongan Akar Tunggang Bengkok Terhadap Pertumbuhan Bibit Cengkeh (Syzygium aromaticum), Universitas Muhammadiyah Surakarta. Arang Sampah Organik, CV IRDH" 1971 2189 W4323980435.pdf 5 29 separator 0.9041351 ¶ 2191 2193 W4323980435.pdf 5 30 bibliography 0.9951748 "[2] Yohana E dan Askhabulyamin, 2009, Perhitungan Efisiensi Dan Konversi Dari Bahan Bakar Solar Ke Gas Pada Boiler Ebara HKL 1800 KA, Volume 11, Rotasi [3] Rachma t Subagyo, 2018, Bahan Ajar : Sistem Pembangkit Uap dan Turbin, Universitas Lambung Mangkurat, Banjarbaru" 2193 2493 W4323980435.pdf 5 31 separator 0.6535219 ¶ 2495 2497 W4323980435.pdf 5 32 bibliography 0.9937004 "[4] Lalu Mustiadi, 2020, Buku Ajar Distilasi Uap Dan Bahan Bakar Pelet [5] Sjahrul Bustaman, 2011, Potensi Pengembangan Minyak Daun Cengkih Sebagai Komoditas Ekspor Maluku, Litbang Pertanian, Bogor" 2497 2723 W4323980435.pdf 5 33 separator 0.9928569 ¶ 2725 2727 W4323980435.pdf 5 0 text 0.99933946 "performance drop, showing no material failure. This proves that one of the major challenges for elastocaloric cooling on its way to commercialization can be resolved by choosing a compression- based concept for ECSs. At the same time, it was possible to show a cooling power of 7.9 W corresponding to a speci fic cooling power of 6,270 W kg−1, which means nearly one order of mag- nitude increase compared to the best ECS-systems based on bulk ECMs21. This was possible by using latent heat of fluid duringevaporation and condensation for a fast and ef ficient heat transfer to heat sink and source. By connecting several segments in series,the maximum temperature span of the AEH can be signi ficantly increased in the future. Hereby, the speci fic cooling capacity approximately scales inversely to the number of cascaded segments 41,43, while the second law ef ficiency of the system is independent from the number of stages." 0 948 W3195478454.pdf 3 1 separator 0.9214545 ¶ 948 950 W3195478454.pdf 3 2 text 0.99950063 "In this work the loading of the elastocaloric material was done by compression. It is also possible to adapt the AEH concept to tensile loading, potentially leading to even larger speci fic cooling capacities." 950 1165 W3195478454.pdf 3 3 separator 0.69708264 ¶ 1165 1167 W3195478454.pdf 3 4 text 0.99878246 "Thus, latent heat transfer in elastocaloric cooling systems can pave the way to many applications for an energy-ef ficient and environmentally friendly alternative to existing cooling technologies." 1167 1370 W3195478454.pdf 3 5 separator 0.99453366 ¶ 1370 1372 W3195478454.pdf 3 6 title 0.98210293 Methods 1372 1380 W3195478454.pdf 3 7 separator 0.99340254 ¶ 1380 1382 W3195478454.pdf 3 8 text 0.9995514 "Material . The ECM used in the setup are nickel-titanium tubes with 56.25 wt% nickel and 43.73 wt% titanium (alloy contents below 0.03% are not listed) with anaustenite finishing temperature of A f=−1.4 °C and were purchased from EUROFLEX GmbH. According to manufacturer ’s speci fications, the tubes have an outer diameter of 2.40 ± 0.01 mm and an inner diameter of 1.45 ± 0.04 mm. Thetubes were cut and polished to a length of 11.005 ± 0.010 mm. The speci fic heat capacity of the alloy is 540 ± 90 J kg −1K−1and was measured by Ingpuls GmbH in a differential scanning calorimeter." 1382 1977 W3195478454.pdf 3 9 separator 0.9256165 ¶ 1977 1979 W3195478454.pdf 3 10 text 0.99954677 "Before measuring the adiabatic temperature change, the ECM was trained over more than 2,000 cycles. The adiabatic temperature span was then measured in aself-made experimental material characterization setup, giving 17.2 ± 0.5 K for loading and 11.9 ± 0.5 K for unloading for a compressive stress of 1234 ± 7 MPa (Supplementary Fig. 1). The uncertainty of the temperature results from thespecifications of the thermocouple manufacturer and the uncertainty of the stress results from the manufacturer ’s speci fications of the force sensor from HBM GmbH." 1979 2541 W3195478454.pdf 3 11 separator 0.99630433 ¶ 2541 2543 W3195478454.pdf 3 12 title 0.93862027 Setup of single-stage AEH-system 2543 2576 W3195478454.pdf 3 13 separator 0.8515824 2576 2577 W3195478454.pdf 3 14 text 0.9856751 ". Supplementary Fig. 2a shows the experi- mental setup for long-term-stability measurements of the single-stage AEH-system." 2577 2702 W3195478454.pdf 3 15 separator 0.8369618 ¶ 2702 2704 W3195478454.pdf 3 16 text 0.9993947 "The system consists of a crankshaft that compresses one elastocaloric segment, which is located between evaporator and condenser. The eccentricity the crankshaft is 300 μm with a tolerance of ± 30 μm. The force is measured with the sensor C10Force Sensor from Hottinger Baldwin Messtechnik GmbH and determines the maximum stress. The maximum load is F max=21 kN with a reading accuracy of 1 kN. This corresponds to a maximum stress σmaxof 1226 ± 70 MPa." 2704 3168 W3195478454.pdf 3 17 separator 0.9847596 ¶ 3168 3170 W3195478454.pdf 3 18 text 0.996346 "Supplementary Fig. 2b shows the elastocaloric segment consisting of two connectors holding the check valves (Supplementary Fig. 2d) and a bellow, where the compressive force can be applied to. Six tubes of Ni 56,25Ti43,73 were fixed by sample holders to prevent them from slipping (Supplementary Fig. 2c) and are integrated into the segment." 3170 3519 W3195478454.pdf 3 19 separator 0.9517405 ¶ 3519 3521 W3195478454.pdf 3 20 text 0.99553025 "The check valves (Supplementary Fig. 2d) separate the evaporator and condenser from the segment. With water as heat transfer fluid, a temperature difference of 1 K across the check valve results in a heat flow of 166 W in forward0" 3521 3754 W3195478454.pdf 3 21 table 0.48978257 2468 1 0 3754 3762 W3195478454.pdf 3 22 separator 0.38293988 3762 3763 W3195478454.pdf 3 23 table 0.9037431 "¶ Cycles n 1060246Temperature span [K]a) P = 0 W P = 2 Wfit fit 012345678 Cooling power [W]b) n 106 n 4,5*106 n 107model model model" 3763 3920 W3195478454.pdf 3 24 separator 0.9902298 ¶ 3920 3922 W3195478454.pdf 3 25 caption 0.9238293 "Fig. 3 Long-term stability of the active elastocaloric heat pipe (AEH). a The temperature span versus the number of cycles n at a frequency of 0.8 Hz is plotted in green with zero and in orange with 2 W of heating load at the evaporator. The data are in agreement with a linear for the entire measurement series (lines). The linear fit for the maximum temperature span ΔTisΔT1⁄45:2K/C0" 3922 4309 W3195478454.pdf 3 26 text 0.5249998 n 4309 4310 W3195478454.pdf 3 27 caption 0.5484133 /C13:8/C110/C 4310 4323 W3195478454.pdf 3 28 text 0.5063279 08K 4323 4326 W3195478454.pdf 3 29 caption 0.6753884 , for 2 W it is 4326 4341 W3195478454.pdf 3 30 text 0.60578126 ΔT1⁄43:1K/C0n 4341 4353 W3195478454.pdf 3 31 caption 0.94494474 "/C15:2/C110/C08K. Error bars as calculated as described in the methods. bMeasurement of the temperature span at different heat loads at a frequency of 0.8 Hz. The data points at the beginning of the long-term measurement are shown in green, after 4.5 × 106cycles in orange and after more than 107cycles in grey. The linear fiti s expected41. The calculation of the errors is given in the methods." 4353 4754 W3195478454.pdf 3 32 separator 0.97574735 ¶ 4754 4756 W3195478454.pdf 3 33 table 0.98316634 "10-210-1100101102 Cooling power [W]100102104106108Number of cycles n" 4756 4828 W3195478454.pdf 3 34 separator 0.47648862 4828 4829 W3195478454.pdf 3 35 table 0.48310137 ¶ 4829 4830 W3195478454.pdf 3 36 bibliography 0.9780316 "Ossmer et al.Brüderlin et al. & Chluba et al. Snodgras et al.Engelbrecht et al. & Tusek et al. ^This work Qian et al. Michaelis et al." 4830 4971 W3195478454.pdf 3 37 separator 0.80731773 ¶ 4971 4973 W3195478454.pdf 3 38 table 0.9698297 "Tensile load Compressive load ECS & ECM test setupRunout Failure No data for n" 4973 5060 W3195478454.pdf 3 39 separator 0.9859964 ¶ 5060 5062 W3195478454.pdf 3 40 caption 0.9923774 "Fig. 4 Comparison of cooling power and long-term stability of different elastocaloric cooling systems (ECS) or material test setups10,15,18,20–22,24,42.A square indicates tests under tensile load, the star indicates compressive load. A red frame around the data point indicates the value at which the sample in a test failed. A black frame marks tests that were stopped after a certain number of cycles (runout). Data without reported cycle stability are shown in grey. Material composition, sample shape, amount of material, stress, strain, frequency and temperature vary in the results plotted. " 5062 5676 W3195478454.pdf 3 41 text 0.7403523 Both, the work of 5676 5693 W3195478454.pdf 3 42 caption 0.475306 Brüder 5693 5700 W3195478454.pdf 3 43 text 0.965435 "lin et al.22 and Chluba et al.10as well as Engelbrecht et al.20and Tu šek et al.21are marked green, since they have demonstrated their long-term stability in a material test setup rather than in an ECS." 5700 5908 W3195478454.pdf 3 44 paratext 0.9732344 "ARTICLE COMMUNICATIONS PHYSICS | https://doi.org/10.1038/s42005-021-00697-y 4 COMMUNICATIONS PHYSICS | (2021) 4:194 | https://doi.org/10.1038/s42005-021-00697-y | www.nature.com/commsphys" 5908 6107 W3195478454.pdf 3 0 text 0.9903641 "¶ forecasts can also contain relevant information to infer an online (or real-time) snapshot of voltage profiles." 1 118 W2889306332.pdf 2 1 separator 0.98580843 "¶ ¶" 119 129 W2889306332.pdf 2 2 caption 0.99666685 "Figure 1 - Voltage magnitude variation over 240 instants of 30 minutes at phase a of node 1 of high_PV (see section IV.A)." 129 255 W2889306332.pdf 2 3 separator 0.9791521 ¶ 256 258 W2889306332.pdf 2 4 caption 0.9958068 "Figure 2 - Voltage magnitude correlation between the same phase of nodes 2 and 12 (left picture) and between phases a and b of nodes 9 and 22 (right picture) of high_PV (see section IV.A)." 258 453 W2889306332.pdf 2 5 separator 0.99637437 ¶ 454 456 W2889306332.pdf 2 6 title 0.993954 III. LOW VOLTAGE STATE ESTIMATOR (LVSE) 456 496 W2889306332.pdf 2 7 separator 0.9929249 ¶ 497 499 W2889306332.pdf 2 8 title 0.98408395 A. General Framework 499 520 W2889306332.pdf 2 9 separator 0.989774 ¶ 521 523 W2889306332.pdf 2 10 text 0.9948006 "The basic principle behind the proposed LVSE is to search for analog voltage events in the historical dataset, using a set of explanatory variables, and extrapolate the current operating state from past information. This naturally relies on information collected online (or in real time) from a subset of smart meters, but also explores other types of information, mainly related to the autocorrelation of the voltage time series and influence of weather and calendar variables in the load patterns that results in voltage variations along the day. The analog-search procedure is described in section III.B and Figure 3 illustrates a set of potential explanatory variables." 523 1228 W2889306332.pdf 2 11 separator 0.80260164 ¶ 1229 1231 W2889306332.pdf 2 12 text 0.9875419 "In brief, the method explores recent and current measures collected by the subset of smart meters with real-time communication and MV/LV substation meter, together with voltage observations from the previous day and from all the meters installed in the LV grid and MV/LV substation. Information about the most recent numerical weather predictions (NWP), like global horizontal irradiance or ambient temperature, can be also integrated in the model. The same is valid for measurements collected by a weather station. Information about demand response actions or dynamic price signals are other potential explanatory variables if available. " 1231 1902 W2889306332.pdf 2 13 separator 0.5143754 ¶ 1902 1903 W2889306332.pdf 2 14 text 0.99923337 "The outcome is a deterministic estimation (i.e., expected value) of the voltage magnitude in the smart meters without real-time communication, which combined with the others meters provide a real-time snapshot of the system state." 1903 2143 W2889306332.pdf 2 15 separator 0.99413717 ¶ 2145 2147 W2889306332.pdf 2 16 caption 0.995931 "Figure 3 – Group of potential explanatory variables for the low voltage state estimator." 2147 2239 W2889306332.pdf 2 17 separator 0.98887324 ¶ 2241 2243 W2889306332.pdf 2 18 text 0.9995371 "The lack of full observability leads to uncertainty in the estimated variables, which is also conditional to the grid current operating conditions (e.g., level of PV generation, observability). Section III.C describes a methodology based on kernel density estimation (KDE) to derive a conditional and non-parametric uncertainty estimation. This statistical method requires a set of hyper-parameters that need to be estimated offline (to avoid “flat start”) and online (to adjust to changes in the grid structure and measurements). The model’s tuning process is described in section III.D." 2243 2859 W2889306332.pdf 2 19 separator 0.9970199 ¶ 2860 2862 W2889306332.pdf 2 20 title 0.9941187 B. Deteministic State Estimation Formulation 2862 2907 W2889306332.pdf 2 21 separator 0.99606335 ¶ 2908 2910 W2889306332.pdf 2 22 text 0.99936193 "This estimation methodology relies on the idea that information regarding the current state of the system can be used to quantify how analogous a given known past state is [15]. When running, the state estimator searches for similarities, for each node’s phase n, computing a weighted average as in Eq. 1, where the estimated voltage for the current instant t, V෠௡,௧, is obtained as a weighted average of past states (instants H)." 2910 3359 W2889306332.pdf 2 23 separator 0.9911897 ¶ 3360 3362 W2889306332.pdf 2 24 math 0.9299616 "V෠௡,௧=∑V௡,௛∙w௡,௛,௧ு ௛ୀଵ ∑w௡,௛,௧ு ௛ୀଵ (1)" 3363 3410 W2889306332.pdf 2 25 separator 0.82917297 ¶ 3411 3413 W2889306332.pdf 2 26 text 0.9840608 "The smoothing coefficients, wn,h,t, are in this method calculated considering: i) The distance ( d௡,௛,௧) between the explanatory variables at instant t and at each instant of the past, h. In this work, we considered the absolute distance (Eq. 2) for the K explanatory variables contained in vector u." 3413 3731 W2889306332.pdf 2 27 separator 0.9524215 ¶ 3732 3734 W2889306332.pdf 2 28 math 0.91719025 "d௡,௛,௧=෍หu௞,௛−u௞,௧ห௄ ௞ୀଵ (2)" 3735 3766 W2889306332.pdf 2 29 text 0.9770471 "¶ ii) The bandwidth δ௡ that defines the selection window of data according to the distances. Here, it is computed as a percentage pr (tuning parameter) of the range of distances, d௠௜௡ and d௠௔௫ (Eq. 3)." 3767 3978 W2889306332.pdf 2 30 separator 0.9239349 ¶ 3979 3981 W2889306332.pdf 2 31 math 0.9176242 δ௡=d௠௜௡+pr(d௠௔௫−d௠௜௡) (3) 3982 4008 W2889306332.pdf 2 32 separator 0.91998994 ¶ 4009 4011 W2889306332.pdf 2 33 text 0.9211774 "Other alternatives to the range of distances could be chosen like the median or the mean distance [15]. iii) A function that weights the past instants according to distances and within the bandwidth (Eq. 4), where α is a tuning parameter, μ is the center of the distribution of distances, τ௠ is the age in hours of the selected historical 0.930.950.970.991.011.031.051.07V_n1_a (p.u.)" 4011 4411 W2889306332.pdf 2 34 separator 0.9498583 ¶ 4411 4413 W2889306332.pdf 2 35 table 0.9081216 "timestamp 0.910.950.991.031.07 0.91 0.95 0.99 1.03 1.07V_n2_a (p.u.) V_n12_a (p.u.)0.90.9511.051.1 0.9 0.94 0.98 1.02 1.06V_n9_a (p.u) V_n22_b (p.u.)Current Instant timet t-1t-2 t-24" 4413 4611 W2889306332.pdf 2 36 separator 0.5540848 ¶ 4611 4613 W2889306332.pdf 2 37 table 0.7669611 "Voltage from smart meters with real-time communication and MV/LV substation Most recent NWPVoltage from ALL smart meters and MV/LV substation" 4613 4784 W2889306332.pdf 2 0 text 0.99742156 "moral duty under conditions of distributive injustice ”and “may not exhaust the scope of legally enforceable duty, ”but should be recognized as a minimum.25Thus, although the duties that infuse contract are “ultimately interpersonal moral duties, ”their content (meaning the prohibition against exacerbating or exploiting distributive injustice) “turns on the nor- mative state of the world (i.e., distributive justice or injustice) and related facts about distribution. ”26" 0 486 W4281741890.pdf 9 1 separator 0.96409184 ¶ 486 488 W4281741890.pdf 9 2 text 0.9987922 "Bagchi sees nothing arbitrary in “recognizing those distribution-sensitive constraints in the liability conditions of contract law. ”27Quite the contrary, “distributive injustice is imbedded in the moral structure of our interper- sonal relations, and plays a direct role in de fining the scope of individual responsibility. ”28Indeed, by focusing on the duty to refrain from exploiting distributive injustice, this account helps to re fine the speci fic obligations toward the poor and disadvantaged incumbent on those who seek to inter- act with them through a direct, pro fitable exchange.29It also clari fies that the requirements of contractual fairness need not be overridden by the vic-tim’s consent." 488 1207 W4281741890.pdf 9 3 separator 0.827278 ¶ 1207 1209 W4281741890.pdf 9 4 text 0.9904471 "30Finally, honing the relationship between contract and dis- tributive justice along these lines is consistent with the observation that contract law is “less sympathetic to those whose weak bargaining power reflects bad luck rather than distributive injustice. ”31" 1209 1480 W4281741890.pdf 9 5 separator 0.98720825 ¶ 1480 1482 W4281741890.pdf 9 6 text 0.99952424 "Like Bagchi, we hold that a theory of contractual fairness can hardly be oblivious to the exploitation of a party ’s poverty or disadvantageous predic- ament but we are far less certain that the prohibition against such exploita- tion is best justi fied, as she argues, by reference to distributive justice. Our concern is twofold. On the one hand, this prohibition is often unlikely tovindicate distributive justice and, on the other, the prohibition against exploitation of a party ’s poverty seems only one aspect of a nondistributive conception of justice, which Bagchi ’s framework obscures." 1482 2090 W4281741890.pdf 9 7 separator 0.9801899 ¶ 2090 2092 W4281741890.pdf 9 8 text 0.99927837 "Bagchi is aware of both these dif ficulties. She recognizes that “regulating terms risks increasing transaction costs for some parties, ”and concedes that these costs become “perverse ”when “they are disproportionately borne by the socially disadvantaged. ”But this “futility ”challenge, she argues, is highly contingent, as it depends on “how a variety of market actors value exchange on a variety of terms. ”" 2092 2512 W4281741890.pdf 9 9 separator 0.90556574 ¶ 2512 2514 W4281741890.pdf 9 10 text 0.99523866 "32Bagchi also acknowledges that not all cases of illegitimate contractual exploitation are “marked by background distributive injustice, ”but insists that the fact that so many are is telling.33" 2514 2713 W4281741890.pdf 9 11 separator 0.9754959 ¶ 2713 2715 W4281741890.pdf 9 12 text 0.9476441 These responses, however, are unpersuasive. 2715 2759 W4281741890.pdf 9 13 separator 0.99335265 ¶ 2759 2761 W4281741890.pdf 9 14 bibliography 0.9819427 "25.Id.at 135. 26. Bagchi, supra note 22, at 197. 27.Id.at 195. 28. Bagchi, supra note 24, at 147. 29.Id.at 125. 30.SeeBagchi, supra note 22, at 202 –207. 31. Bagchi, supra note 24, at 136. 32. Bagchi, supra note 22, at 209 –210. 33.SeeBagchi, supra note 24, at 139.HANOCH DAGAN AND AVIHAY DORFMAN 98" 2761 3077 W4281741890.pdf 9 15 separator 0.9460882 ¶ 3077 3079 W4281741890.pdf 9 16 paratext 0.98517144 https://doi.org/10.1017/S1352325222000076 Published online by Cambridge University Press 3079 3169 W4281741890.pdf 9 0 paratext 0.9875406 Materials 2021 ,14, 173 5 of 13 0 31 W3115880296.pdf 4 1 separator 0.81184727 ¶ 31 33 W3115880296.pdf 4 2 paratext 0.9812102 Materials 2020, 13, x FOR PEER REVIEW 5 of 13 33 80 W3115880296.pdf 4 3 separator 0.9928981 ¶ 81 83 W3115880296.pdf 4 4 table 0.7511489 "K2CO 3 → K2O + CO 2 (2) K2CO 3 + 2C → 2K + 3CO (3) K2O+C → 2K + CO (4) CO 2 + C → 2CO (5)" 84 187 W3115880296.pdf 4 5 separator 0.9842249 ¶ 188 190 W3115880296.pdf 4 6 text 0.9996112 "These reaction s showed that the oxidization of the carbon atom would be enhanced when the temperature was over 700 °C, which meant more oxygen atom in the carbon would be consumed during the carbonization process . That wa s the reason for lower oxygen con- tent in ACRF -50C-85%-800 than ACRF -50C-85%-600 or ACRF -50C-85%-700." 190 532 W3115880296.pdf 4 7 separator 0.97444487 ¶ ¶ 534 540 W3115880296.pdf 4 8 caption 0.995713 "Figure 2. X-ray photoelectron spectroscopy (XPS) spectra of all ACRFs ( A) and deconvolution of O 1s peaks of ACRF -50-85%-600 ( B), ACRF -50-85%-700 (C) and ACRF -50-85%-800 ( D)" 540 725 W3115880296.pdf 4 9 separator 0.99585676 ¶ 726 728 W3115880296.pdf 4 10 title 0.99313796 3.3. Porosity of ACRFs 728 751 W3115880296.pdf 4 11 separator 0.9958159 ¶ 753 755 W3115880296.pdf 4 12 text 0.99843615 "The macroporous morphologies of PRFs and AC RFs were presented in Figure 3. For all the PRFs, the typical SEM images of the porous material obtained via concentrated emu lsion t emplate could be seen [25,26 ]—there were many closely -packed cavities (which were called “voids”) interconnected with the adjacent ones by small pores (which were called “windows”). It was found that the size of voids could be tuned by adjusting the composition of conce ntrated emulsion —in PRF -50C-80%, PRF -50C-85%, and PRF -50C- 90% the size of voids increased with the increasing dispersed phase volume fraction in concentrated emulsion, and in PRF -50C-85%, PRF -40C-85%, and PRF -30C-85% the sizes of voids decreased with the d ecreasing concentration of continuous phas e in concentrated emulsion. For ACRF s, ACRF -50C-80%-800, ACRF -50C-85%-800, and ACRF -40C-85%-800 all inherit ed the marocporous structures of their corresponding PRFs. However, the size of macropores in ACRF -50C-90%-800 and ACRF -30C-85%-800 shrank obviously, which illustrated that the macropores in PRF -50C-90% and PRF -30C-85% collapsed during the carbonization process [27]. The marcoporous morphologies of ACRF -50C-85%-600, ACRF -50C-85%-700, and ACRF -50C-85%-800 were similar ( Figure S2), indicating that the influence of carbonization temperature on macropores in ACRFs was limited . In general, the macroporous structure of ACRFs could be tuned by concentrated emulsion to some extent." 755 2273 W3115880296.pdf 4 13 separator 0.99483776 ¶ 2275 2277 W3115880296.pdf 4 14 table 0.9200816 "A C B D" 2277 2291 W3115880296.pdf 4 15 separator 0.97828794 ¶ 2292 2294 W3115880296.pdf 4 16 caption 0.9961634 "Figure 2. X-ray photoelectron spectroscopy (XPS) spectra of all ACRFs ( A) and deconvolution of O 1s peaks of ACRF-50-85%-600 ( B), ACRF-50-85%-700 ( C) and ACRF-50-85%-800 ( D)." 2294 2475 W3115880296.pdf 4 17 separator 0.90252316 ¶ 2475 2477 W3115880296.pdf 4 18 caption 0.4917954 2477 2478 W3115880296.pdf 4 19 table 0.8693225 "When the temperature is over 700C: K2CO 3!K2O + CO 2 (2) K2CO 3+ 2C!2K + 3CO (3) K2O+C!2K + CO (4) CO 2+ C!2CO (5)" 2478 2601 W3115880296.pdf 4 20 separator 0.9665149 ¶ 2601 2603 W3115880296.pdf 4 21 text 0.99929297 "These reactions showed that the oxidization of the carbon atom would be enhanced when the temperature was over 700C, which meant more oxygen atom in the carbon would be consumed during the carbonization process. That was the reason for lower oxygen content in ACRF-50C-85%-800 than ACRF-50C-85%-600 or ACRF-50C-85%-700." 2603 2930 W3115880296.pdf 4 22 separator 0.9973844 ¶ 2930 2932 W3115880296.pdf 4 23 title 0.9935622 3.3. Porosity of ACRFs 2932 2955 W3115880296.pdf 4 24 separator 0.99581563 ¶ 2955 2957 W3115880296.pdf 4 25 text 0.9976897 "The macroporous morphologies of PRFs and ACRFs were presented in Figure 3. For all the PRFs, the typical SEM images of the porous material obtained via concentrated emulsion template could be seen [ 25,26]—there were many closely-packed cavities (which were called “voids”) interconnected with the adjacent ones by small pores (which were called “windows”). It was found that the size of voids could be tuned by adjusting the composition of concentrated emulsion—in PRF-50C-80%, PRF-50C-85%, and PRF-50C- 90% the size of voids increased with the increasing dispersed phase volume fraction in concentrated emulsion, and in PRF-50C-85%, PRF-40C-85%, and PRF-30C-85% the sizes of voids decreased with the decreasing concentration of continuous phase in concentrated emulsion. For ACRFs, ACRF-50C-80%-800, ACRF-50C-85%-800, and ACRF-40C-85%- 800 all inherited the marocporous structures of their corresponding PRFs. However, the size of macropores in ACRF-50C-90%-800 and ACRF-30C-85%-800 shrank obviously, which illustrated that the macropores in PRF-50C-90% and PRF-30C-85% collapsed during the carbonization process [ 27]. The marcoporous morphologies of ACRF-50C-85%-600, ACRF-50C-85%-700, and ACRF-50C-85%-800 were similar (Figure S2), indicating that the influence of carbonization temperature on macropores in ACRFs was limited. In general, the macroporous structure of ACRFs could be tuned by concentrated emulsion to some extent." 2957 4425 W3115880296.pdf 4 0 paratext 0.9906866 Page 13/14 0 10 W4241125781.pdf 12 1 separator 0.991922 ¶ 10 12 W4241125781.pdf 12 2 caption 0.9421368 Figure 2 12 21 W4241125781.pdf 12 3 separator 0.9590329 ¶ 21 23 W4241125781.pdf 12 4 caption 0.8322184 "Relationship between climatic factors and infectivity of SARS-CoV-2 across the Spanish AA.CC. Data on UVR (J/m2), temperature (oC), and relative humidity (%) were collected from the months with the highest infectivity. These meteorological variables were correlated with the cumulative incidence (previous 14 days) x105 inhabitants, on March 15 for February climate variables and on April 15 for March climate variables. *p<0.001." 23 462 W4241125781.pdf 12 0 paratext 0.98926216 Page 4 of 11 Hsieh et al. BMC Ophthalmology (2022) 22:44 0 66 W4210675544.pdf 3 1 separator 0.99230915 ¶ 67 69 W4210675544.pdf 3 2 title 0.9866307 Table 1 Demographics and Baseline characteristics 69 119 W4210675544.pdf 3 3 separator 0.982641 ¶ 119 121 W4210675544.pdf 3 4 table 0.9766233 "Values are presented as N (%) or mean (SD) P value for chi square test or two independent t test *represent P value less than 0.05case (N = 19) control (N = 17) P value Age 7.78 (0.88) 8.31 (1.01) 0.109 Sex 0.187 Male 12 (63.2%) 7 (41.2%) Female 7 (36.8%) 10 (58.8%) Anisometropia or Isometropia 0.167 A 18 (94.7%) 13 (76.5%) I 1 (5.3%) 4 (23.5%) Anisometropia definition met 0.143 Cylinder only (≥1.50D difference) 1 (5.3%) 2 (11.8%) Spherical equivalent only (≥0.50D difference) 11 (57.9%) 10 (58.8%) Spherical equivalent and cylinder 7 (36.8%) 1 (5.9%) Refractive error in amblyopia eye – 0 to + 1.00D 0 (0%) 1 (5.9%) + 1.00D to < + 2.00D 0 (0%) 2 (11.8%) + 2.00D to < + 3.00D 1 (5.3%) 1 (5.9%) + 3.00D to < + 4.00D 1 (5.3%) 1 (5.9%) + 4.00D to < + 5.00D 5 (26.3) 4 (23.5%) ≥ + 5.00D 1 (5.3%) 4 (23.5%) -1.00D to 0 1 (5.3%) 0 (0%) -2.00D to < −1.00D 0 (0%) 2 (11.8%) -3.00D to < −2.00D 4 (21.1%) 0 (0%) -4.00D to < −3.00D 0 (0%) 0 (0%) -5.00D to < −4.00D 4 (21.1%) 1 (5.9%) < −5.00D 2 (10.5%) 1 (5.9%) Depth of Amblyopia 0.051 severe (> 0.7 logMAR) 2 (10.5%) 5 (29.4%) moderate (0.3 to 0.7 logMAR) 10 (52.7%) 12 (70.6%) mild (< 0.3 logMAR) 7 (36.8%) 1 (5.9%)" 121 1371 W4210675544.pdf 3 5 separator 0.9929176 ¶ 1371 1373 W4210675544.pdf 3 6 title 0.9648052 Table 2 Improvement of BCVA from baseline to follow‐up visits in 2 groups 1373 1447 W4210675544.pdf 3 7 separator 0.9915775 ¶ 1447 1449 W4210675544.pdf 3 8 table 0.78752977 "Data presented as mean (SD). p value for two independent t test Δ0–1: Difference between 3rd month and baseline Δ0–2: Difference between 6th month and baseline Δ0–3: Difference between 9th month and baseline Δ0–4: Difference between 12th month and baseline Δ0-E: Difference between endpoint and baseline *represent P value less than 0.05Variables Δ0–1Δ0–2Δ0–3Δ0-E" 1449 1825 W4210675544.pdf 3 9 separator 0.6368847 ¶ 1825 1827 W4210675544.pdf 3 10 table 0.9352665 "control case P value control case P value control case P value control case P value logMAR N = 13 N = 18 N = 6 N = 3 N = 1 N = 1 N = 17 N = 19 0.07 (0.18) 0.32 (0.20) 0.005* 0.12 (0.15) 0.23 (0.21) 0.356 0.30 (−) 0.40 (−) – 0.12 (0.18) 0.29 (0.20) 0.006*" 1827 2086 W4210675544.pdf 3 0 text 0.99969876 "Accordingly, the electrophysiological studies that target this lateral nucleus demonstrate that ghrelin decreases the frequency ofmEPSCs recorded, indicating that ghrelin reduces synaptictransmission in this area. Specificity of this effect to GHS-R1Awas verified by the fact that co-application of a GHS-R1Aantagonist with ghrelin abolished ghrelin’s electrophysiologicaleffects. Given that the lateral amygdaloid nucleus is considered tobe functionally linked to affective motivated behavior, connectedto the nucleus accumbens [42], it is well placed to receive andcontribute to ghrelin’s effects on food intake and food-motivatedbehavior. Indeed, this subnucleus of the amygdala, that we nowdemonstrate is ghrelin-responsive, is known to be important forappetitive learning and for assigning emotional and motivationalsignificance to environmental cues [43–45]." 0 866 W2073559421.pdf 6 1 separator 0.99422896 ¶ 866 868 W2073559421.pdf 6 2 text 0.99968326 "Previous studies have shown that hyper-excitability of pyrami- dal-like neurons in the lateral amygdaloid nucleus is linked toanxiety-like behavior [46]. Conversely, it has also been shown thata reduction of this activity, for example via activation of inhibitoryneuropeptide Y-expressing neurons, leads to a reduction inanxiety-like behavior [47]. This is especially relevant to thepresent study in which we demonstrate that ghrelin administrationnot only suppresses the activity of the pyramidal-like neurons inthis area but also suppresses anxiety-like behavior in the EPM testwhen administered directly into the amygdala. Thus ourelectrophysiology data are supportive of the behavioral results,as ghrelin reduces both the activation of pyramidal-like neurons and anxiety-like behavior." 868 1662 W2073559421.pdf 6 3 separator 0.9914074 ¶ 1662 1664 W2073559421.pdf 6 4 text 0.9995419 "Previous studies determining the effects of intra-amygdala injection of ghrelin on feeding behavior are not altogether in agreement; whereas one study reported no effect on regular chow intake [19] another reported a decrease in liquid food intake [48]." 1664 1924 W2073559421.pdf 6 5 separator 0.9321998 ¶ 1924 1926 W2073559421.pdf 6 6 text 0.9996651 "In the present study we found that intra-amygdala injection of ghrelin robustly increased food intake in fed rats given free access to normal chow. Note that, in the present study, ghrelin was administered, by microinjection of a small volume, to the part of the amygdala where GHS-R is most abundant thereby limiting diffusion to adjacent structures (as depicted in Fig. 1). Given that lesions of the amygdala have been shown to increase or decrease food intake in a site-specific manner [49], we may infer that the focal site of ghrelin injection (including spread from the injection site) may be critical for determining the feeding response, and likely differs between these different studies." 1926 2644 W2073559421.pdf 6 7 separator 0.9900345 ¶ 2644 2646 W2073559421.pdf 6 8 text 0.99966717 "Previously we demonstrated that central administration of a ghrelin receptor antagonist suppresses the hyperphagia observed after an overnight fast [33]. Given that ghrelin levels are high during fasting [50], providing a strong motivational drive for food intake [5–7,39], these findings suggest that endogenous ghrelin could have a role in hunger-induced food intake. Here we extendthese studies to demonstrate that food intake after an overnight fast can be reduced by administration of a ghrelin receptor antagonist directly into the amygdala. We may infer, therefore, that" 2646 3238 W2073559421.pdf 6 9 separator 0.9763408 ¶ 3238 3240 W2073559421.pdf 6 10 caption 0.9962657 "Figure 6. Effects of intra-amygdala administration of ghrelin on anxiety-like behavior in rats given access to food. In rats given access to food during the first hour after intra-amygdala injection (FOOD ACCESS), ghrelin increased food intake relative to saline controls (g of chow), bo th during this hour and during the 1 hr measurement taken after the anxiety tests (A). In this paradigm there was no effect of ghrelin (relative to saline controls) on anxiety-like behavior in either the EPM test (time spent in the open arm; B) or the open field test (central activity or central rearing; C, D respectively). *P ,0.05 **P ,0.01, vs. saline. Independent samples t-test, SPSS." 3240 3928 W2073559421.pdf 6 11 separator 0.9404527 ¶ 3928 3930 W2073559421.pdf 6 12 paratext 0.92723495 doi:10.1371/journal.pone.0046321.g006Ghrelin and Amygdala 3930 3988 W2073559421.pdf 6 13 separator 0.74081075 ¶ 3988 3990 W2073559421.pdf 6 14 paratext 0.9790528 PLOS ONE | www.plosone.org 7 October 2012 | Volume 7 | Issue 10 | e46321 3990 4063 W2073559421.pdf 6 0 separator 0.66564566 ¶ 1 5 W2896675998.pdf 3 1 paratext 0.96224284 ¶ Rev. Ambient . Água vol. 13 n. 5, e2051 - Taubaté 2018 5 62 W2896675998.pdf 3 2 separator 0.66390026 ¶ 64 66 W2896675998.pdf 3 3 paratext 0.95938975 4 Douglas Cavalcante Costa et al. 67 102 W2896675998.pdf 3 4 separator 0.9950634 ¶ 104 106 W2896675998.pdf 3 5 text 0.9979798 "30,5 a 32°C e as mínimas entre 21,0 a 22,5°C. O período mais chuvoso ocorre de dezembro a maio com cerca de 80% dos totais pluviais e, entre junho a novembro são contabilizados o restante do volume precipitado na região (Varela -Ortega et al., 2013)." 106 363 W2896675998.pdf 3 6 separator 0.97745925 ¶ ¶ 365 371 W2896675998.pdf 3 7 caption 0.98872596 "Figura 1. Mapa de localização do polo de grãos Santarém/Belterra no oeste do Pará, Amazônia." 371 467 W2896675998.pdf 3 8 separator 0.9880222 ¶ 469 471 W2896675998.pdf 3 9 text 0.99889326 "Para calcular a pegada hídrica total das oito cultivares testadas na região, fez -se as estimativas das pegadas hídricas verde e cinza a partir dos valores em ren dimento dessas cultivares, mas os valores de estimativas de taxas evapotranspiratórias foram contabilizados considerando a duração do ciclo e condições térmico -hídricas em cada ano/safra, no período de 2009 a 2014, conforme descrito a seguir." 471 890 W2896675998.pdf 3 10 separator 0.8629815 ¶ 892 894 W2896675998.pdf 3 11 text 0.99899095 "Como na regi ão de estudo os cultivos não são irrigados, a PH azul foi desconsiderada na contabilização da pegada hídrica total." 894 1026 W2896675998.pdf 3 12 separator 0.9969888 ¶ 1028 1030 W2896675998.pdf 3 13 title 0.99228936 2.1. Pegada hídrica verde (PH verde) 1030 1068 W2896675998.pdf 3 14 separator 0.99513775 ¶ 1069 1071 W2896675998.pdf 3 15 text 0.9993035 "Para o cálculo de evapotranspiração da cultura no polo de grãos de Santarém/Belterra foi utilizado o modelo CROPWAT 8.0 que foi desenvolvido pela Organização das Nações Unidas para Agricultura e Alimentação (FAO, 2010). Nessa ferramenta foram inseridos os dados mensais, correspondentes ao período de 2009 a 2014. Assim, inseriram -se os val ores de precipitação pluvial (mm), temperatura máxima e mínima (°C), umidade relativa do ar (%) e velocidade do vento (m s-1), oriundos de estação automática do Instituto Nacional de Meteorologia (INMET) e posto pluvial da Agência Nacional de Águas (ANA). Os valores de coeficiente da cultura (Kc) adotados foram 0 ,4, 1,15 e 0 ,5, correspondentes a fase inicial, média e final, respectivamente (Allen et al., 1998). Identifica -se na Amazônia a predominância de Latossolo Amarelo, o que determinou os valores de en trada gerais do solo no software. A PH verde foi estimada baseando -se nos dados de clima, de precipitação e no período de semeadura de cada cultivar apontad os na Tabela 1. Utilizou -se a metodologia de Hoekstra et al. (2011)," 1071 2191 W2896675998.pdf 3 16 separator 0.9313177 ¶ 2192 2194 W2896675998.pdf 3 17 text 0.4886863 Equação 2194 2202 W2896675998.pdf 3 18 caption 0.7267637 1. 2202 2205 W2896675998.pdf 3 19 separator 0.99652326 ¶ 2206 2208 W2896675998.pdf 3 0 paratext 0.9608976 "Adang Djumhur Salikin, Ilham Bustomi, Irfan Zidny 299 299" 0 114 W2903887178.pdf 7 1 separator 0.981586 ¶ 115 117 W2903887178.pdf 7 2 text 0.84864247 "Dan kewajiban penulis adalah taat kepada Allah SWT dan Rasul -Nya, serta mengembalikan kepada Allah dan rasul - Nya jika terjadi perbedaan pendapat." 118 276 W2903887178.pdf 7 3 separator 0.9930109 ¶ ¶ 278 284 W2903887178.pdf 7 4 title 0.9867651 DAFTAR PUSTAKA 284 299 W2903887178.pdf 7 5 separator 0.99049485 ¶ ¶ 301 307 W2903887178.pdf 7 6 bibliography 0.9915111 "Abu Zahrah , Tārikh al -Madz āhib al - Islāmiyah , 1989 Dar al -Fikr al - Arabi, Kairo" 307 399 W2903887178.pdf 7 7 separator 0.9390404 ¶ 401 403 W2903887178.pdf 7 8 bibliography 0.993738 "Abu Zahrah, Ibnu Hazm Hay ātuhū wa Ashruh ū Arā‟uhū wa Fiqhuh ū, 1997 Dar al -Fikr, Kairo" 403 501 W2903887178.pdf 7 9 separator 0.9369086 ¶ 503 505 W2903887178.pdf 7 10 bibliography 0.9860194 "Al-Imam Muaffiq al -Dīn Abdullah bin Ahmad bin Qud āmah al -Maqsidi, al-Mughniy , Juz VIII, Beirut: Daar al -Kutub al -Ilmiyah, t.th" 505 647 W2903887178.pdf 7 11 separator 0.86528516 ¶ 649 651 W2903887178.pdf 7 12 bibliography 0.9905699 "Hasballah Thaib dan Mara Halim Harahap, Hukum Keluarga Dalam Syariat Islam , Al-Azhar, 2010 Medan: Universitas" 651 775 W2903887178.pdf 7 13 separator 0.9791527 ¶ 777 779 W2903887178.pdf 7 14 bibliography 0.79271597 "Henni Handayani , Tinjauan yuridis gugat cerai yang dilakukan via sms (short message services) menurut Hukum Islam dan Undang - Undang No.1 tahun 1974 : studi kasus putusan Pengadilan Agama" 779 984 W2903887178.pdf 7 15 separator 0.6050433 ¶ 985 987 W2903887178.pdf 7 16 bibliography 0.923836 Bangkalan 987 997 W2903887178.pdf 7 17 separator 0.5458282 ¶ 998 1000 W2903887178.pdf 7 18 bibliography 0.9472352 "No.0253/Pdt.G/2013/PA.Bkl , 2013 Jakarta, Fakulas Hukum Universitas Indonesia:" 1000 1088 W2903887178.pdf 7 19 separator 0.7413696 ¶ 1090 1092 W2903887178.pdf 7 20 bibliography 0.99335504 "Ibnu Hazm, al-iḥkām fī uṣūl al -aḥkām , 1998 Dar al -Fikr Beirut Ibnu Hazm , al-Muhalla bil Atsar , Beirut: Dar al Fikr, t.th" 1092 1228 W2903887178.pdf 7 21 separator 0.7649039 ¶ 1230 1232 W2903887178.pdf 7 22 bibliography 0.9953964 "Ibnu Hazm , al-Muhalla, Juz X, Dar al - Fikr, t.th , Cairo" 1232 1293 W2903887178.pdf 7 23 separator 0.9818766 ¶ 1296 1298 W2903887178.pdf 7 24 bibliography 0.9672939 "Liliyah Linda Fianti , Perceraian Melalui SMS (Short Message Service) Menurut Hukum Islam , 20 03 Surabaya , Fakultas Hukum Universitas Airlangga" 1298 1456 W2903887178.pdf 7 25 separator 0.9764563 ¶ 1459 1461 W2903887178.pdf 7 26 bibliography 0.99422103 "M.Yahya Harahap, Kedudukan, Kewenangan, dan Acara Peradilan Agama , 2003 Sinar Grafika, Jakarta" 1461 1567 W2903887178.pdf 7 27 separator 0.94518626 ¶ 1569 1571 W2903887178.pdf 7 28 bibliography 0.9933617 "Nana Syaodih Sukmadinata, Metode Penelit ian Pendidikan , 2010 PT. Remaja Rosdakarya, Bandung" 1571 1672 W2903887178.pdf 7 29 separator 0.90400827 ¶ 1675 1677 W2903887178.pdf 7 30 bibliography 0.9938015 "Noeng Muhadjir, Metodologi Penelitian kualitatif , 1996 Rakesarasin, Yogyakarta" 1677 1766 W2903887178.pdf 7 31 separator 0.97075516 ¶ 1768 1770 W2903887178.pdf 7 32 bibliography 0.97974324 "Rima Safria , Perselingkuhan Melalui Facebook dan SMS Akibat Penyebab Perceraian (Studi pada Pengadilan Agama Surakarta) , 2014 Jakarta, Fakulas Syari‟ah dan Hukum UIN Syarif" 1770 1961 W2903887178.pdf 7 33 separator 0.61201835 ¶ 1962 1964 W2903887178.pdf 7 34 bibliography 0.9901547 "Hidayutullah Slamet Abidin dan Aminudin, Fiqih Munakahat I, 2011 Pustaka Setia , Bandung: CV." 1964 2069 W2903887178.pdf 7 35 separator 0.7325274 ¶ 2071 2073 W2903887178.pdf 7 36 bibliography 0.9917974 "Wjs Peorwardamita, Kamus Umum Bahasa Indonesia ,: 2006 Balai Pustaka Jakarta" 2073 2156 W2903887178.pdf 7 37 separator 0.9940637 ¶ 2158 2160 W2903887178.pdf 7 0 title 0.9692458 Table 3 Summary of the available “viewing software ”smartphone applications. 0 76 W1998211972.pdf 3 1 text 0.72929853 "*Price refers to the advertised cost of downloading the application from the application store; additional costs are not included. MIP=maximum intensity projection, MPR=multiplanar reformatting, PACS=picture archiving and communication system, ROI=region of int erest, SUV=specific uptake value, VRT= volume-rendering technique, W/L=window level" 76 426 W1998211972.pdf 3 2 separator 0.9902617 ¶ 426 428 W1998211972.pdf 3 3 table 0.9734321 "Application name Application storeDeveloper Price* FDA approved Advertised viewing featuresPACS Advertised limitations Tablet application available Centricity Radiology Mobile AccessApple/ Google PlayGE Healthcare Free No Zoom, pan, scroll, W/L, 2D, 3D, MIP, MPRGE Centricity PACS Not for diagnostic use Yes DicomDroid Google Play Mediko srl €20.62 No Not stated Any PACS None stated Yes DocBookMD Google Play DocBookMD Free No Not stated Any PACS via messaging applicationNone stated Yes" 428 937 W1998211972.pdf 3 4 separator 0.7621584 ¶ 937 939 W1998211972.pdf 3 5 table 0.98172164 "Doshi Diag Apple My Personal Health Record ExpressFree No Zoom, scroll, cine loop Doshi Diagnostics PACS Not for diagnostic use No eFilm Mobile Apple Merge Healthcare Free No Zoom, pan, W/L eFilm PACS Not for diagnostic use Yes ENDEAVOR Google Play Computer Vision Research GroupFree No Zoom, pan, scroll, W/L, annotateAny PACS None stated Yes" 939 1293 W1998211972.pdf 3 6 separator 0.7546916 ¶ 1293 1295 W1998211972.pdf 3 7 table 0.97923887 "Fujifilm Synapse MobilityApple/ Google PlayFujifilm Medical Systems USAFree Yes (for iPhone/ iPad)Zoom, W/L, 2D, 3D, MIP, MPRFujifilm systems PACS For diagnostic use on iPhone/iPadYes" 1295 1491 W1998211972.pdf 3 8 separator 0.9102831 ¶ 1491 1493 W1998211972.pdf 3 9 table 0.9696583 "iClarity Lite: Advanced Medical ImagingViewer and ImageManagement ToolApple iCRco Inc. Free No Zoom, pan, scroll, W/L, measurement,cine loopAny PACS Not for diagnostic use Yes" 1493 1673 W1998211972.pdf 3 10 separator 0.8858801 ¶ 1673 1675 W1998211972.pdf 3 11 table 0.986218 "iClarity: Advanced Medical ImagingViewer and ImageManagement ToolApple iCRco Inc. €3.54 No Zoom, pan, scroll, W/L, measure, cine loopAny PACS Not for diagnostic use Yes" 1675 1848 W1998211972.pdf 3 12 separator 0.8703254 ¶ 1848 1850 W1998211972.pdf 3 13 table 0.98653716 "Independent Apple My Personal Health Record ExpressFree No Zoom, scroll, cine loop Independent Imaging ’s PACSNot for diagnostic use Yes" 1850 1991 W1998211972.pdf 3 14 separator 0.8777773 ¶ 1991 1993 W1998211972.pdf 3 15 table 0.97604 "INFINITT Mobile ViewerApple/ Google PlayINFINITT Healthcare Free No Zoom, pan, W/L, cine, measure, ROIINFINITT PACS Not for diagnostic use Yes inteleGRID Apple Intelemage Free No Zoom, pan, scroll, W/L Any PACS None stated Yes" 1993 2228 W1998211972.pdf 3 16 separator 0.60055727 ¶ 2228 2230 W1998211972.pdf 3 17 table 0.98933357 "IOP Mobile Apple ZED Technologies Free No Not stated Olympic Park PACS None stated YesiPaxera Apple Paxeramed Corp €3.54 No Zoom, pan, rotate, W/L, measureAny PACS Not for diagnostic use Yes" 2230 2423 W1998211972.pdf 3 18 separator 0.7691651 ¶ 2423 2425 W1998211972.pdf 3 19 table 0.95099264 "MITK Pocket Apple Medical Embedded SystemsFree No Zoom, MPR, W/L, measure, annotationAny PACS None stated Yes Mobile MIM Apple MIM Software Free Yes 2D, 3D, MIP, measure, annotate, SUVAny PACS Only to be used when no accessto workstations.Not for mammographyYes" 2425 2697 W1998211972.pdf 3 20 separator 0.9338014 ¶ 2697 2699 W1998211972.pdf 3 21 table 0.9878579 "MphRx Apple My Personal Health Free No Zoom, scroll, cine loop Any PACS via MphRx cloudsystemNot for diagnostic use No" 2699 2820 W1998211972.pdf 3 22 separator 0.54289985 ¶ 2820 2822 W1998211972.pdf 3 23 table 0.97500455 "MRDS Google Play Inrete SRL Free No Not stated Any PACS None stated Yes OsiriX HD Apple Pixmeo SARL €24.88 No Zoom, pan, rotate, W/L , cine , measure, ROIAny PACS Not for diagnostic use Yes" 2822 3016 W1998211972.pdf 3 24 separator 0.6112217 ¶ 3016 3018 W1998211972.pdf 3 25 table 0.98688895 "ResolutionMD Mobile Apple/ Google PlayCalgary Scientific Free Yes (for iPhone/ iPad)Zoom, pan, W/L, 2D, 3D, MIP, MPR,measure, cineResolutionMD PACS For diagnostic use on iPhone/iPad. Notfor mammographyYes" 3018 3231 W1998211972.pdf 3 26 paratext 0.98702484 558 Insights Imaging (2013) 4:555 –562 3231 3269 W1998211972.pdf 3 0 paratext 0.9895329 Infrastructures 2021 ,6, 20 6 of 11 0 35 W3126576191.pdf 5 1 separator 0.81084394 ¶ 35 37 W3126576191.pdf 5 2 paratext 0.98147225 Infrastructures 2021 , 6, x FOR PEER REVIEW 6 of 10 37 89 W3126576191.pdf 5 3 separator 0.75118 "¶ ¶" 90 100 W3126576191.pdf 5 4 caption 0.9880553 Figure 6. Maximum lateral deflection case of an 8-story building. 100 166 W3126576191.pdf 5 5 separator 0.9588165 ¶ ¶ 167 173 W3126576191.pdf 5 6 caption 0.98917186 Figure 7. Maximum lateral deflection case of a 10-story building. 173 239 W3126576191.pdf 5 7 separator 0.99372214 ¶ 240 242 W3126576191.pdf 5 8 text 0.99387395 "Comparing the results of the maximum displacements of the fixed base and the other soil type models, we can observe that the effects of the SSI increase the displacements considerably between the 5-story and 8-story case s. It increases by 96% at the 5-story level for the soil type 4, which is less than between the 8-story and 10-story cases which increase by 37% at the 5-story level of soil type 4. It is observable that the case of soil type 1 does not present any difference in displace- ment values with the fixed base for the three cases, which proves that the fixed base is only valid with a non-cohesive soil. In addition, we can observe that in all case s, we exceeded the limit value of the code but it is amplified with the increasing stor y structure and the decreasing soil rigidity." 242 1069 W3126576191.pdf 5 9 separator 0.9963451 ¶ 1070 1072 W3126576191.pdf 5 10 title 0.9935167 3.2. Inter-Story Drift Results 1072 1103 W3126576191.pdf 5 11 separator 0.9965978 ¶ 1104 1106 W3126576191.pdf 5 12 text 0.99723625 The inter-story drift mentioned below is calculated by the following: 1106 1176 W3126576191.pdf 5 13 separator 0.9294712 ¶ 1177 1179 W3126576191.pdf 5 14 math 0.68636954 Drift 1179 1185 W3126576191.pdf 5 15 text 0.64538276 1185 1186 W3126576191.pdf 5 16 math 0.84105337 "= d (i + 1) − d (i) h (2)" 1186 1215 W3126576191.pdf 5 17 text 0.9509144 ¶ The limitation of the code in our case is given by 1% [25]. 1215 1277 W3126576191.pdf 5 18 separator 0.5611696 ¶ 1278 1280 W3126576191.pdf 5 19 text 0.99768895 "As the figures show, the inter-story drift increases considerably between levels 1 and 2 (Figures 8–10), with a small difference between the case of rigid soil (non-cohesive soil) and the embedded base case." 1280 1495 W3126576191.pdf 5 20 separator 0.9951652 ¶ 1496 1498 W3126576191.pdf 5 21 caption 0.98879826 Figure 6. Maximum lateral deflection case of an 8-story building. 1498 1563 W3126576191.pdf 5 22 separator 0.9847965 ¶ 1563 1565 W3126576191.pdf 5 23 paratext 0.9831197 Infrastructures 2021 , 6, x FOR PEER REVIEW 6 of 10 1565 1617 W3126576191.pdf 5 24 separator 0.8364951 "¶ ¶" 1618 1628 W3126576191.pdf 5 25 caption 0.9884413 Figure 6. Maximum lateral deflection case of an 8-story building. 1628 1694 W3126576191.pdf 5 26 separator 0.90380895 ¶ ¶ 1695 1701 W3126576191.pdf 5 27 caption 0.99087095 Figure 7. Maximum lateral deflection case of a 10-story building. 1701 1767 W3126576191.pdf 5 28 separator 0.99354684 ¶ 1768 1770 W3126576191.pdf 5 29 text 0.9937392 "Comparing the results of the maximum displacements of the fixed base and the other soil type models, we can observe that the effects of the SSI increase the displacements considerably between the 5-story and 8-story case s. It increases by 96% at the 5-story level for the soil type 4, which is less than between the 8-story and 10-story cases which increase by 37% at the 5-story level of soil type 4. It is observable that the case of soil type 1 does not present any difference in displace- ment values with the fixed base for the three cases, which proves that the fixed base is only valid with a non-cohesive soil. In addition, we can observe that in all case s, we exceeded the limit value of the code but it is amplified with the increasing stor y structure and the decreasing soil rigidity." 1770 2597 W3126576191.pdf 5 30 separator 0.9965967 ¶ 2598 2600 W3126576191.pdf 5 31 title 0.9932073 3.2. Inter-Story Drift Results 2600 2631 W3126576191.pdf 5 32 separator 0.9967203 ¶ 2632 2634 W3126576191.pdf 5 33 text 0.9975151 The inter-story drift mentioned below is calculated by the following: 2634 2704 W3126576191.pdf 5 34 separator 0.93464243 ¶ 2705 2707 W3126576191.pdf 5 35 math 0.67446977 Drift 2707 2713 W3126576191.pdf 5 36 text 0.6843236 2713 2714 W3126576191.pdf 5 37 math 0.8275231 "= d (i + 1) − d (i) h (2)" 2714 2743 W3126576191.pdf 5 38 text 0.95101184 ¶ The limitation of the code in our case is given by 1% [25]. 2743 2805 W3126576191.pdf 5 39 separator 0.575871 ¶ 2806 2808 W3126576191.pdf 5 40 text 0.9978898 "As the figures show, the inter-story drift increases considerably between levels 1 and 2 (Figures 8–10), with a small difference between the case of rigid soil (non-cohesive soil) and the embedded base case." 2808 3023 W3126576191.pdf 5 41 separator 0.9935223 ¶ 3024 3026 W3126576191.pdf 5 42 caption 0.9927478 Figure 7. Maximum lateral deflection case of a 10-story building. 3026 3091 W3126576191.pdf 5 43 separator 0.9849137 ¶ 3091 3093 W3126576191.pdf 5 44 text 0.9984445 "It can also be noticed that the non-cohesive soil (type 1) has practically the same value as the fixed base case." 3093 3208 W3126576191.pdf 5 45 separator 0.90995383 ¶ 3208 3210 W3126576191.pdf 5 46 text 0.9990297 "Comparing the results of the maximum displacements of the fixed base and the other soil type models, we can observe that the effects of the SSI increase the displacements considerably between the 5-story and 8-story cases. It increases by 96% at the 5-story level for the soil type 4, which is less than between the 8-story and 10-story cases which increase by 37% at the 5-story level of soil type 4." 3210 3619 W3126576191.pdf 5 47 separator 0.52887046 ¶ 3619 3621 W3126576191.pdf 5 48 text 0.9955942 "It is observable that the case of soil type 1 does not present any difference in displace- ment values with the fixed base for the three cases, which proves that the fixed base is only valid with a non-cohesive soil. In addition, we can observe that in all cases, we exceeded the limit value of the code but it is amplified with the increasing story structure and the decreasing soil rigidity." 3621 4020 W3126576191.pdf 5 0 paratext 0.9884477 693 Scientometrics (2023) 128:651–698 0 37 W4309042737.pdf 42 1 separator 0.51787025 38 39 W4309042737.pdf 42 2 paratext 0.8535309 ¶ 1 3 39 44 W4309042737.pdf 42 3 separator 0.9915559 ¶ 44 46 W4309042737.pdf 42 4 text 0.9956891 "To clarify the importance of positive sorting in enhancing quality in academia, I also estimated the total academic output with and without the sorting effect. I interpret the aca- demic output as a result of high-level teaching and high-impact research. Following de la Croix et al. (2022), I first aggregate the individual quality of every scholar i predicted to teach in a university k to compute institutions’ output (characterized as a CES production function), and I aggregate them to compute the total output of the model—with and with- out the sorting effect. I proceed as follows: where ̂pik is the predicted probability for a scholar i to choose university k, as shown in the three examples above. These values weigh scholar’s human capital qi . The additional parameter /u1D70C denotes the elasticity of substitution between individual quality of profes- sors in producing institutions’ output. This parameter is crucial because, by assuming it to be finite, it demonstrates complementarity between professors. As /u1D70C falls, the gains from matching better scholars in the best institutions rise, improving the total output. The results are in the main text, Table 9.(17)" 46 1267 W4309042737.pdf 42 5 math 0.6622637 Y=/ 1267 1271 W4309042737.pdf 42 6 text 0.61666226 uni2211 1271 1278 W4309042737.pdf 42 7 math 0.58903056 .s1 1278 1281 W4309042737.pdf 42 8 separator 0.7020149 ¶ 1281 1283 W4309042737.pdf 42 9 math 0.897056 "k/parenleft.s4 /uni2211.s1 îpikqρ−1 ρ i/parenright.s4 ρ ρ−1" 1283 1354 W4309042737.pdf 42 10 title 0.8282967 Table 25 Predicted values of individual location choice probabilities—role of sorting 1354 1440 W4309042737.pdf 42 11 table 0.99345005 "¶ Benchmark (6) Benchmark (6)—NO sorting A B C A B C Birthplace ln of HCFlorence 10.097 (%)Florence 4.415 (%)Florence 2.487 (%)Florence 10.097 (%)Florence 4.415 (%)Florence 2.487 (%) UNIROMA2 6.5 3.0 2.1 3.3 2.1 1.8 UNIBO 11.1 7.7 6.3 7.2 6.2 5.5 UNITO 4.1 2.1 1.5 2.8 1.7 1.4 UNIMI 7.3 4.3 3.3 5.7 3.7 3.0 UNIPD 6.3 4.0 3.2 5.1 3.5 3.0 LUISS 3.6 2.3 1.8 3.2 2.1 1.7 CATT 6.1 3.9 3.1 5.7 3.7 3.0 UNIVPM 3.8 2.8 2.4 4.0 2.8 2.3 UNIVE 5.6 4.2 3.5 6.3 4.3 3.6 BOCCONI 4.9 3.6 3.0 5.6 3.7 3.0 UNITN 3.4 2.4 2.0 3.9 2.5 2.0 BICOCCA 4.8 3.5 2.9 5.6 3.6 3.0 UNIFI 23.5 49.0 58.5 28.8 51.9 60.0 UNIVR 3.0 2.6 2.2 4.0 2.8 2.4 UNIBA 1.3 0.8 0.7 1.7 0.9 0.7 FUB 2.7 2.1 1.8 3.9 2.4 1.9 UNIROMA1 2.2 1.8 1.6 3.1 2.0 1.7" 1440 2201 W4309042737.pdf 42 0 paratext 0.7028314 Yang et 0 7 W2914522527.pdf 4 1 title 0.88041645 al. Serum Uric Acid Levels and BPPV 7 43 W2914522527.pdf 4 2 separator 0.99653137 ¶ 43 45 W2914522527.pdf 4 3 caption 0.9953401 FIGURE 4 | Sensitivity analysis of the studies in serum uric acid level between the BPPV and control groups. 45 154 W2914522527.pdf 4 4 separator 0.98804635 ¶ 154 156 W2914522527.pdf 4 5 caption 0.9954019 "FIGURE 5 | Forest plot of serum uric acid level as an independent risk fa ctor for BPPV across all studies, in the subset of studies con ducted within China or in the subset conducted outside China. The x-axis shows the 95% con fidence interval." 156 403 W2914522527.pdf 4 6 separator 0.9896952 ¶ 403 405 W2914522527.pdf 4 7 text 0.994884 "acid levels can trigger inflammation of the gelatinous matri x to which otoconia are connected ( 33,34); uric acid can promote the release of inflammatory mediators that induce productionof damaging reactive oxygen species (ROS). Through a similar inflammatory mechanism, elevated serum uric acid levels may trigger production of ROS that damage the vasculature ( 35,36)," 405 782 W2914522527.pdf 4 8 separator 0.98871636 ¶ 782 784 W2914522527.pdf 4 9 paratext 0.9793567 Frontiers in Neurology | www.frontiersin.org 5 February 2019 | Volume 10 | Article 91 784 870 W2914522527.pdf 4 0 title 0.77462345 Collisions of random walks in reversible random graphs 0 54 W868410753.pdf 5 1 separator 0.9874128 ¶ 54 56 W868410753.pdf 5 2 title 0.9172875 References 56 67 W868410753.pdf 5 3 separator 0.9942664 ¶ 67 69 W868410753.pdf 5 4 bibliography 0.9957257 "[1]David Aldous and James Allen Fill, Reversible markov chains and random walks on graphs , 2002, Unfinished monograph, recompiled 2014." 69 207 W868410753.pdf 5 5 separator 0.93347454 ¶ 207 209 W868410753.pdf 5 6 bibliography 0.99706507 "[2]David Aldous and Russell Lyons, Processes on unimodular random networks , Electron. J. Probab. 12(2007), no. 54, 1454–1508. MR-2354165" 209 349 W868410753.pdf 5 7 separator 0.83276653 ¶ 349 351 W868410753.pdf 5 8 bibliography 0.9971263 "[3]Omer Angel and Oded Schramm, Uniform infinite planar triangulations , Comm. Math. Phys. 241 (2003), no. 2-3, 191–213. MR-2013797" 351 484 W868410753.pdf 5 9 separator 0.88216186 ¶ 484 486 W868410753.pdf 5 10 bibliography 0.9976655 "[4]Martin T. Barlow, Yuval Peres, and Perla Sousi, Collisions of random walks , Ann. Inst. Henri Poincaré Probab. Stat. 48(2012), no. 4, 922–946. MR-3052399" 486 645 W868410753.pdf 5 11 separator 0.8383162 ¶ 645 647 W868410753.pdf 5 12 bibliography 0.9976429 "[5]I. Benjamini, R. Lyons, Y. Peres, and O. Schramm, Group-invariant percolation on graphs , Geom. Funct. Anal. 9(1999), no. 1, 29–66. MR-1675890" 647 795 W868410753.pdf 5 13 separator 0.72836924 ¶ 795 797 W868410753.pdf 5 14 bibliography 0.9974169 "[6] Itai Benjamini and Nicolas Curien, Ergodic theory on stationary random graphs , Electron. J. Probab. 17(2012), no. 93, 20. MR-2994841" 797 937 W868410753.pdf 5 15 separator 0.7926956 ¶ 937 939 W868410753.pdf 5 16 bibliography 0.9974543 "[7]Itai Benjamini and Oded Schramm, Recurrence of distributional limits of finite planar graphs , Electron. J. Probab. 6(2001), no. 23, 13 pp. (electronic). MR-1873300" 939 1108 W868410753.pdf 5 17 separator 0.8455795 ¶ 1108 1110 W868410753.pdf 5 18 bibliography 0.99752194 "[8]XinXing Chen and DaYue Chen, Two random walks on the open cluster of Z2meet infinitely often , Sci. China Math. 53(2010), no. 8, 1971–1978. MR-2679079" 1110 1265 W868410753.pdf 5 19 separator 0.7617426 ¶ 1265 1267 W868410753.pdf 5 20 bibliography 0.9977049 "[9]Ori Gurel-Gurevich and Asaf Nachmias, Recurrence of planar graph limits , Ann. of Math. (2) 177 (2013), no. 2, 761–781. MR-3010812" 1267 1403 W868410753.pdf 5 21 separator 0.852672 ¶ 1403 1405 W868410753.pdf 5 22 bibliography 0.9973526 "[10] Olle Häggström, Infinite clusters in dependent automorphism invariant percolation on trees , Ann. Probab. 25(1997), no. 3, 1423–1436. MR-1457624" 1405 1556 W868410753.pdf 5 23 separator 0.79316854 ¶ 1556 1558 W868410753.pdf 5 24 bibliography 0.99748707 "[11] Antal A. Járai, Incipient infinite percolation clusters in 2D , Ann. Probab. 31(2003), no. 1, 444–485. MR-1959799" 1558 1678 W868410753.pdf 5 25 separator 0.8495568 ¶ 1678 1680 W868410753.pdf 5 26 bibliography 0.9974956 "[12] Harry Kesten, The incipient infinite cluster in two-dimensional percolation , Probab. Theory Related Fields 73(1986), no. 3, 369–394. MR-859839" 1680 1830 W868410753.pdf 5 27 separator 0.91931784 ¶ 1830 1832 W868410753.pdf 5 28 bibliography 0.9973878 [13] Maxim Krikun, Local structure of random quadrangulations , arXiv:math/0512304 (2005). 1832 1923 W868410753.pdf 5 29 separator 0.6307984 ¶ 1923 1925 W868410753.pdf 5 30 bibliography 0.99202156 "[14] Manjunath Krishnapur and Yuval Peres, Recurrent graphs where two independent random walks collide finitely often , Electron. Comm. Probab. 9(2004), 72–81 (electronic). MR- 2081461" 1925 2113 W868410753.pdf 5 31 separator 0.9285798 ¶ 2113 2115 W868410753.pdf 5 32 bibliography 0.9975005 "[15] Thomas M. Liggett, Interacting particle systems , Classics in Mathematics, Springer-Verlag, Berlin, 2005, Reprint of the 1985 original. MR-2108619" 2115 2269 W868410753.pdf 5 33 separator 0.9521767 ¶ 2269 2271 W868410753.pdf 5 34 bibliography 0.9934639 "[16] R. Lyons and Y. Peres, Probability on trees and networks , Cambridge University Press, 2015, In preparation. Current version available at http://mypage.iu.edu/~rdlyons/ ." 2271 2451 W868410753.pdf 5 35 separator 0.8434478 ¶ 2451 2453 W868410753.pdf 5 36 bibliography 0.9977652 "[17] J. R. Norris, Markov chains , Cambridge Series in Statistical and Probabilistic Mathematics, vol. 2, Cambridge University Press, Cambridge, 1998, Reprint of 1997 original. MR-1600720" 2453 2643 W868410753.pdf 5 37 separator 0.99400985 ¶ 2643 2645 W868410753.pdf 5 38 text 0.9116763 "Acknowledgments. This work was carried out while TH was an intern at Microsoft Research. We thank Itai Benjamini for suggesting this problem, and also thank Lewis Bowen, Perla Sousi and Omer Tamuz for helpful discussions." 2645 2871 W868410753.pdf 5 39 separator 0.9885858 ¶ 2871 2873 W868410753.pdf 5 40 paratext 0.95901436 "ECP20(2015), paper 63. Page 6/6ecp.ejpecp.org" 2873 2921 W868410753.pdf 5 0 paratext 0.83674276 Jin et al. C 0 12 W4283793114.pdf 1 1 title 0.6361059 holesterol Efflux Capacity and Vascular Diseases 12 59 W4283793114.pdf 1 2 separator 0.9875092 ¶ 59 61 W4283793114.pdf 1 3 title 0.97199917 INTRODUCTION 61 74 W4283793114.pdf 1 4 separator 0.99297166 ¶ 74 76 W4283793114.pdf 1 5 text 0.99958485 "Epidemiologic studies have shown an inverse relationship between high-density lipoprotein (HDL) cholesterol levels a nd cardiovascular disease ( 1); however, recent clinical trials ( 2,3) and Mendelian randomization (MR) studies ( 4,5) failed to established a clear causal association between HDL cholest erol and cardiovascular disease. This led to the hypothesis that t he atheroprotective role of HDL lies in its function rather than in itsconcentrations( 6)." 76 553 W4283793114.pdf 1 6 separator 0.5543467 ¶ 553 555 W4283793114.pdf 1 7 text 0.99966544 "The most important measure of HDL function is cholesterol efflux capacity (CEC), the ability of HDL to reverse cholestero l transport from peripheral cells ( 7). Previous cohort and case- control studies showed that CEC was inversely associated wi th atherosclerosis and the incidence of cardiovascular event s in the general population, independently of the HDL cholesterol concentration ( 8–11). However, observational epidemiological studies may suffer from confounding and selection bias that represent obstacles to valid causal inference ( 12,13). The causal association between CEC and cardiovascular diseases is sti ll controversial.Furthermore,ischemicstrokehadaheterog eneous mechanism and may have different cause and risk factors from coronary artery disease (CAD) ( 14). Previous MR studies have showed a weaker effect on ischemic stroke than on CAD for some lipid metabolic factors, such as low-density lipoprotein cholesterol and proprotein convertase subtilisin/kexin type 9 (PCSK9) variants ( 15,16). Therefore, the relative effects of CEC onCADandischemicstrokeneedsfurtherinvestigation." 555 1688 W4283793114.pdf 1 8 separator 0.95180774 ¶ 1688 1690 W4283793114.pdf 1 9 text 0.99952865 "MR study, using genetic variants as instrumental variables, is a method that can control potential confounders and revers e causationthatmaybiasobservationalstudies,andmakestr onger causal inferences between an exposure and risk of diseases ( 12)." 1690 1944 W4283793114.pdf 1 10 separator 0.86509264 ¶ 1944 1946 W4283793114.pdf 1 11 text 0.99918723 "Inthepresentstudy,weaimedtouseMRanalysistoexaminethe causalrelevanceofCECforCADandmyocardialinfarction(MI ), andcomparesitwiththatforischemicstrokeanditssubtypes." 1946 2113 W4283793114.pdf 1 12 separator 0.9967578 ¶ 2113 2115 W4283793114.pdf 1 13 title 0.99168336 MATERIALS AND METHODS 2115 2137 W4283793114.pdf 1 14 separator 0.99137986 ¶ 2137 2139 W4283793114.pdf 1 15 title 0.9871038 Study Design 2139 2152 W4283793114.pdf 1 16 separator 0.9936073 ¶ 2152 2154 W4283793114.pdf 1 17 text 0.9996313 "A two-sample MR analysis using CEC-related genetic variants as instrumental variable was designed to evaluate the causa l effect between CEC and risk of CAD and ischemic stroke (SupplementaryFigure1 ).Summary-leveldataontheexposure (CEC) were derived from a recent published genome-wide association study (GWAS) of up to 5,293 European individuals (17) and data on the outcome (CAD and ischemic stroke) were obtained from GWASs of up to 446,696 European individuals ( 18,19).Table1andSupplementaryTable1 shows thecharacteristicsoftheseGWASs.Approvalofethicscommit tee and written informed consent were obtained before data collectionintheoriginalGWASs." 2154 2828 W4283793114.pdf 1 18 separator 0.996926 ¶ 2828 2830 W4283793114.pdf 1 19 title 0.99276704 Genetic Instrumental Variables 2830 2861 W4283793114.pdf 1 20 separator 0.99494576 ¶ 2861 2863 W4283793114.pdf 1 21 text 0.99962646 "We used 6 single nucleotide polymorphisms (SNPs) associated with CEC identified through GWAS by Low-Kam et al. ( 17) as the instrumental variables. Low-Kam et al. ( 17) tested the genetic association between 4 CEC measures and genotypes at>9millioncommon autosomal DNAsequence variantsin5,293 French Canadians. They identified 10 genome-wide significan t signals (P<6.25×10−9) representing 7 loci. Among the 7 loci, 2 loci (near the PPP1CB/PLB1 andRBFOX3/ENPP7 genes) only reached genome-wide significance in the model further adjust ed forHDL-Candtriglyceridelevelswhichmayleadtofalsepositiv e associations in the GWAS context (i.e., collider bias). Oth er 5 loci(CETP,LIPC,LPL,APOA1/C3/A4/A5 ,andAPOE/C1/C2/C4 ) harboredgeneswithimportantrolesinlipidbiologyandreach ed genome-wide significance in the model adjusted for sex, age squared, coronary artery disease status, experimental batch es, statin treatment, and the first 10 principal components. Except for theAPOE/C1/C2/C4 variant, association of other 4 loci disappeared when correcting for HDL-C and triglyceride level s." 2863 3970 W4283793114.pdf 1 22 separator 0.95887685 ¶ 3970 3972 W4283793114.pdf 1 23 text 0.99962145 "Only the SNP of rs141622900 in APOE/C1/C2/C4 locus reached genome-widesignificanceinbothtwomodelsandwasusedasthe instrument. In sensitivity analysis, we used the most signifi cant SNP in each of the 5 loci (rs77069344, rs2070895, rs247616, rs964184, and rs445925) as the instrument. These 5 SNPs were in different genomic regions and not in linkage disequilibrium (r2<0.1). The 1 SNP (rs141622900) instrument explained 0.9% andthe5SNPsinstrumentexplained5.3%ofthevarianceinCEC (Fstatistic=59.2 and 45.9, respectively, indicating sufficient strength of the instruments). Table2shows the characteristics andassociationsoftheseincludedSNPswithCEC." 3972 4632 W4283793114.pdf 1 24 separator 0.9966581 ¶ 4632 4634 W4283793114.pdf 1 25 title 0.9886937 Outcomes 4634 4643 W4283793114.pdf 1 26 separator 0.9949974 ¶ 4643 4645 W4283793114.pdf 1 27 text 0.9847102 "Summary statistics for the association of each CEC-related SNP withtheCADandMIwereextractedfromtheCoronaryARtery DIsease Genome-wide Replication And Meta-Analysis Plus Coronary Artery Disease Genetics (CARDIoGRAMplusC4D) 1000Genomes-basedGWAS( 17).TheCARDIoGRAMplusC4D 1000Genomes-basedGWASinterrogated9.4millionvariants in up to 60,801 CAD cases and 123,504 controls from 48 studies of predominantly European ancestry. Summary statistics for the association of the included SNPs with ischemic stroke an d the 3 main subtypes of ischemic stroke (large artery stroke [LAS], small vessel stroke [SVS], cardioembolic stroke [CE S]) were extracted from the GWAS of Multiancestry Genome-wide Association Study of Stroke (MEGASTROKE) consortium ( 19)." 4645 5415 W4283793114.pdf 1 28 separator 0.9695349 ¶ 5415 5417 W4283793114.pdf 1 29 text 0.99942905 "The MEGASTROKE consortium tested ∼8 million SNPs and indels with minor-allele frequency ≥0.01 in up to 67,162 stroke cases and 454,450 controls from 29 studies, predominantly European ancestry (40,585 cases; 406,111 controls). This GW AS involved 34,217 cases with LAS, 5,386 cases with SVS and 7,19 3 cases with CES of European ancestry. The associations of the 6 individualSNPsforCECwithCADandMI,andischemicstroke anditssubtypesarepresentedin Tables3,4,respectively." 5417 5900 W4283793114.pdf 1 30 separator 0.9965129 ¶ 5900 5902 W4283793114.pdf 1 31 title 0.9918954 Statistical Analysis 5902 5923 W4283793114.pdf 1 32 separator 0.99568844 ¶ 5923 5925 W4283793114.pdf 1 33 text 0.998479 "Per-allele effects of the selected SNPs on CEC and disease outcomes were extracted from the GWASs and used to estimate the causal effect of CEC on outcomes using two-sample MR analyses.UsingtheSNPofrs141622900astheinstrument,Wal d ratio method were used to obtain effect estimate by dividing the SNP-outcome estimate by the SNP-CEC estimate. Standard error were estimated using the Delta method by dividing ¶" 5925 6343 W4283793114.pdf 1 34 paratext 0.9863114 Frontiers in Cardiovascular Medicine | www.frontiersin.o rg 2 July 2022 | Volume 9 | Article 891148 6343 6443 W4283793114.pdf 1 0 paratext 0.98513055 Murray J, et al. BMJ Glob Health 2018;3:e000808. doi:10.1136/bmjgh-2018-00080811BMJ Global Health 0 97 W2883950008.pdf 10 1 separator 0.9600661 ¶ 97 99 W2883950008.pdf 10 2 text 0.99883574 "of delivering it at a national scale in Burkina Faso and other countries). Mass media is an unusual intervention in that it is usually easier to deliver at scale than within the limitations of a cluster trial. Mass media campaigns could potentially be used in any similar setting with minimal demand generation initiative and good service avail-ability, perhaps supplementing existing successful inte-grated community case management activities. Kasteng et al have estimated that the incremental provider cost-ef-fectiveness of a national media campaign in Burkina Faso during the trial period would have been $15 per DALY averted, with a societal cost (including the additional costs to households of changed care-seeking) of $38 per DALY averted." 99 851 W2883950008.pdf 10 3 separator 0.93707913 ¶ 851 853 W2883950008.pdf 10 4 text 0.75525254 "20 For national campaigns in five African countries from 2018 to 2020, the projected provider cost" 853 955 W2883950008.pdf 10 5 bibliography 0.42271137 ranged from 955 967 W2883950008.pdf 10 6 text 0.49616793 $7 to $27 per DALY averted. 967 995 W2883950008.pdf 10 7 separator 0.87572455 ¶ 995 997 W2883950008.pdf 10 8 text 0.97360814 "Our modelling was based on results from a CRT, using routine health facility data that was well powered to detect changes in care seeking and was collected as part of the most rigorous evaluation of a mass media intervention to have been conducted in a developing country. 6 There is extensive evidence, derived from non-randomised studies from multiple low-income countries, that mass media campaigns with adequate exposure can change health-related behaviours affecting child survival. 3 Our projections for other countries illustrate that the impact seen in Burkina Faso is potentially generalisable to other countries with different patterns of treatment seeking and mortality. However, these projections assume that the intervention (with cultural adaptation) would be equally effective at increasing healthcare seeking in other countries, which may not be the case." 997 1882 W2883950008.pdf 10 9 separator 0.9801622 ¶ 1882 1884 W2883950008.pdf 10 10 text 0.984921 "Health facilities in Burkina Faso adopted the District Health Information System (DHIS) 2 data management system in 2013. In 2014, data submissions from health facilities were over 95% complete, 29 but there is limited information available on the quality of the data collected. A further limitation is that the system does not provide precise denominator data. 6" 1884 2258 W2883950008.pdf 10 11 separator 0.8397468 ¶ 2258 2260 W2883950008.pdf 10 12 text 0.9926522 "The average number of diagnoses per consultation increased in both arms over time, from 1.23 to 2.17 in the control arm and from 1.51 to 2.29 in the inter - vention arm (online supplementary appendix 2b). For this reason, it was necessary to compress the absolute numbers of diagnoses in each month to 100% of the total number of consultations to facilitate modelling. By far the largest contributor to this pattern was the other diagnosis category (not targeted by the campaign), which rose more rapidly in the control arm (online supplemen-tary appendix 2c). The reasons for this are unclear." 2260 2860 W2883950008.pdf 10 13 separator 0.9323802 ¶ 2860 2862 W2883950008.pdf 10 14 text 0.9982454 "In our modelling, we made adjustments to reflect the fact that not all sick children taken to a health facility will necessarily receive treatment (perhaps because a health worker did not adhere to guidance, or treatment was not actually required or due to supply-side constraints). We estimated this based on 2010 DHS data (or LiST" 2862 3198 W2883950008.pdf 10 15 title 0.98435646 Table 2 2012–2014 projected lives that could have been saved by a national radio campaign in Burkina Faso 3198 3304 W2883950008.pdf 10 16 separator 0.99199903 ¶ 3304 3306 W2883950008.pdf 10 17 table 0.996452 "Burkina Faso 2012 2013 2014 Under-five lives saved* 6690 (3413 to 10 288) 4143 (336 to 9413) 4055 (1083 to 10 731) Percentage reduction in mortality 9.2 5.6 5.5 Under-five lives saved (10% discounting) 6021 (3072 to 9259) 3729 (302 to 8472) 3650 (975 to 9658) Percentage reduction in mortality 8.3 5.1 5.0 Under-five lives saved (20% discounting) 5352 (2730 to 8230) 3314 (269 to 7530) 3244 (866 to 8585) Percentage reduction in mortality 7.4 4.5 4.4" 3306 3769 W2883950008.pdf 10 18 separator 0.5648813 ¶ 3769 3771 W2883950008.pdf 10 19 table 0.8824852 *Estimated lower and upper bounds shown in brackets. 3771 3824 W2883950008.pdf 10 20 separator 0.99534786 ¶ 3824 3826 W2883950008.pdf 10 21 title 0.72104305 Table 3 Estimated number of under-five lives 3826 3872 W2883950008.pdf 10 22 table 0.5415878 saved 3872 3877 W2883950008.pdf 10 23 title 0.53913873 per 3877 3881 W2883950008.pdf 10 24 table 0.5436965 year 3881 3886 W2883950008.pdf 10 25 title 0.5450519 by a national media 3886 3906 W2883950008.pdf 10 26 table 0.5979456 intervention 3906 3919 W2883950008.pdf 10 27 title 0.5341481 in 3919 3922 W2883950008.pdf 10 28 table 0.9876445 "five low-income countries 2018–2020 LiST projections* Year Burkina Faso Burundi Malawi Mozambique Niger Under-five lives saved2018 4714 (7.7) 3171 (9.8) 7384 (20.7) 8519 (10.9) 6031 (6.7) 2019 2851 (4.6) 1847 (5.5) 5664 (15.5) 4777 (6.0) 3142 (3.4) 2020 2469 (3.9) 2187 (6.4) 6649 (17.9) 8147 (10.0) 4391 (4.6) Under-five lives saved (with 10% discount)2018 4242 (6.9) 2854 (8.8) 6645 (18.6) 7667 (9.8) 5428 (6.0) 2019 2566 (4.1) 1662 (5.0) 5097 (14.0) 4299 (5.4) 2828 (3.0) 2020 2223 (3.5) 1969 (5.8) 5984 (16.1) 7333 (9.0) 3952 (4.1) Under-five lives saved (with 20% discount)2018 3771 (6.1) 2537 (7.8) 5907 (16.5) 6815 (8.7) 4825 (5.4) 2019 2281 (3.7) 1478 (4.4) 4531 (12.4) 3822 (4.8) 2513 (2.7) 2020 1976 (3.1) 1750 (5.1) 5319 (14.3) 6518 (8.0) 3513 (3.7) " 3922 4704 W2883950008.pdf 10 29 separator 0.60503465 ¶ 4704 4705 W2883950008.pdf 10 30 table 0.94935715 *Percentage reductions in mortality are in brackets. 4705 4758 W2883950008.pdf 10 0 paratext 0.888294 "International Journal of Trend in Scientific Resear ch and Development (IJTSRD) ISSN: 2456 @ IJTSRD | Available Online @ www.ijtsrd.com economic and environmental (SEE) impacts as well as tourist-host interaction studies respectively." 0 244 W2922435762.pdf 4 1 separator 0.8962644 ¶ ¶ 245 251 W2922435762.pdf 4 2 title 0.9914952 Method of Data Analysis 251 275 W2922435762.pdf 4 3 separator 0.99457335 ¶ 276 278 W2922435762.pdf 4 4 text 0.99831283 "The study is concerned with finding the impact of a n independent variable (e.g. Tourism, which is deconstructed with sub- variables such as Service, Products, Hotel, Transportation, and Infrastructura l Facilities) on 3 dependent variables (e.g. Economic Well-Being, Ecological Development and Sociological Development). Consequently, the researcher used the Regres sion Analysis of ordinary least square." 278 710 W2922435762.pdf 4 5 separator 0.9939189 ¶ ¶ 711 717 W2922435762.pdf 4 6 title 0.99049115 Model Specification 717 737 W2922435762.pdf 4 7 separator 0.9871982 ¶ 742 744 W2922435762.pdf 4 8 text 0.7850288 "The structural form of the model SOI = f(SER, PRO, HOT, TRAN, INF) ¶ The mathematical form of the model ¶" 744 860 W2922435762.pdf 4 9 math 0.6701204 "SOI = β0 +β1 SER + β2 PRO + β3 HOT + β INF ... (2)" 860 912 W2922435762.pdf 4 10 text 0.6557007 "¶ The econometric form of the model ¶" 913 956 W2922435762.pdf 4 11 math 0.76705706 "SOI = β0 +β1 SER + β2 PRO + β3 HOT + β INF + μi (3)" 956 1012 W2922435762.pdf 4 12 text 0.33673638 ¶ 1013 1015 W2922435762.pdf 4 13 math 0.40686387 ¶ Where 1017 1025 W2922435762.pdf 4 14 text 0.38199723 ; 1025 1026 W2922435762.pdf 4 15 table 0.53823125 ¶ SOD 1027 1034 W2922435762.pdf 4 16 math 0.45597062 = 1034 1035 W2922435762.pdf 4 17 table 0.76924 "SOCIAL DEVELOPMENT SER " 1035 1063 W2922435762.pdf 4 18 math 0.38015077 = 1063 1064 W2922435762.pdf 4 19 table 0.75256246 "SERVICE PRO " 1064 1080 W2922435762.pdf 4 20 math 0.39812914 = 1080 1081 W2922435762.pdf 4 21 table 0.77031463 "PRODUCTS HOT " 1081 1098 W2922435762.pdf 4 22 math 0.3743034 = 1098 1099 W2922435762.pdf 4 23 table 0.7432927 "HOTELS TRA = TRANSPORTATION INF " 1099 1139 W2922435762.pdf 4 24 math 0.46568865 = 1139 1140 W2922435762.pdf 4 25 table 0.71600455 INFRASTRUCTURAL FACILITIES 1140 1167 W2922435762.pdf 4 26 math 0.54668933 ¶ f = 1168 1174 W2922435762.pdf 4 27 text 0.3915223 Function 1174 1183 W2922435762.pdf 4 28 math 0.3880863 al 1183 1185 W2922435762.pdf 4 29 text 0.35231736 relationship 1185 1198 W2922435762.pdf 4 30 math 0.6044427 "¶ β0 = the intercept or the constant β1 – β5 = the co- efficient of the explanatory variables μt = Stochastic error term. ¶ ¶" 1199 1338 W2922435762.pdf 4 31 separator 0.79951745 "¶ ¶ ¶" 1340 1354 W2922435762.pdf 4 32 title 0.9891101 Table 3: Demographic profile of the sample 1354 1397 W2922435762.pdf 4 33 separator 0.9880806 ¶ 1398 1400 W2922435762.pdf 4 34 table 0.9489157 "Demographic profile Sex/Gender Male Female Age 18 -25 26-35 36-60" 1400 1488 W2922435762.pdf 4 35 separator 0.936792 ¶ 1489 1491 W2922435762.pdf 4 36 paratext 0.9489714 "International Journal of Trend in Scientific Resear ch and Development (IJTSRD) ISSN: 2456 www.ijtsrd.com | Volume – 2 | Issue – 6 | Sep- Oct 2018 economic and " 1491 1660 W2922435762.pdf 4 37 title 0.5199029 environmental (SEE 1660 1678 W2922435762.pdf 4 38 paratext 0.551379 ) 1678 1679 W2922435762.pdf 4 39 title 0.55493367 impact 1679 1686 W2922435762.pdf 4 40 paratext 0.52886397 s 1686 1687 W2922435762.pdf 4 41 title 0.6045309 "as well as host interaction studies respectively." 1687 1741 W2922435762.pdf 4 42 separator 0.98576385 ¶ 1743 1745 W2922435762.pdf 4 43 text 0.9942151 "The study is concerned with finding the impact of a n independent variable (e.g. Tourism, which is variables such as Service, Products, Hotel, Transportation, and Infrastructura l Facilities) on 3 dependent variables (e.g. Economic Being, Ecological Development and Sociological Development). Consequently, the sion Analysis of ordinary SOI = f(SER, PRO, HOT, TRAN, INF) ...(1)" 1745 2148 W2922435762.pdf 4 44 separator 0.79296315 ¶ 2149 2151 W2922435762.pdf 4 45 math 0.7735764 "HOT + β4 TRAN + β5 HOT + β4 TRAN + β5 INF = INFRASTRUCTURAL FACILITIES" 2151 2229 W2922435762.pdf 4 46 text 0.29914346 ¶ 2231 2233 W2922435762.pdf 4 47 table 0.40834308 efficient 2233 2243 W2922435762.pdf 4 48 text 0.46457088 of the ex 2243 2253 W2922435762.pdf 4 49 table 0.5197497 planatory variables 2253 2272 W2922435762.pdf 4 50 title 0.990425 Table 2: Economic a priori expectation 2273 2312 W2922435762.pdf 4 51 separator 0.96276796 ¶ 2313 2315 W2922435762.pdf 4 52 title 0.6053901 Parame 2315 2322 W2922435762.pdf 4 53 table 0.6326715 ¶ 2323 2325 W2922435762.pdf 4 54 title 0.5809138 ters 2325 2330 W2922435762.pdf 4 55 table 0.94877046 "Variables Regr ess and Regre ss or β0 SOI Interc ept β1 SOI SER β2 SOI PRO β3 SOI HOT β4 SOI TRA β5 SOI INF Source:" 2330 2482 W2922435762.pdf 4 56 text 0.5558807 Research 2482 2491 W2922435762.pdf 4 57 table 0.45236066 ers 2491 2494 W2922435762.pdf 4 58 text 0.46255746 2494 2495 W2922435762.pdf 4 59 table 0.5604322 compilation 2495 2506 W2922435762.pdf 4 60 separator 0.9813597 ¶ 2507 2509 W2922435762.pdf 4 61 text 0.99783784 "A positive '+' sign indicate that the relationship between the regress or and regress move in the sa me direction i.e. increase or decrease together. On the other hand, a ' indirect (inverse) relationship between the regress and regress and i.e. they move in opposite or different direction." 2509 2817 W2922435762.pdf 4 62 separator 0.99328923 ¶ ¶ 2818 2824 W2922435762.pdf 4 63 title 0.99289596 DATA PRESENTATION AND ANALYSIS 2824 2855 W2922435762.pdf 4 64 separator 0.99017894 ¶ 2856 2858 W2922435762.pdf 4 65 title 0.94941777 Administ ration and Collection of Instrument 2858 2903 W2922435762.pdf 4 66 separator 0.9632561 ¶ 2904 2906 W2922435762.pdf 4 67 text 0.99684507 "The total number of questionnaire distributed was 400. This was determined by the sample size of the study. The number returned was a total of 300copies , representing 75% (percent) of number distributed. This shows that the number not returned was 100 (25%). Based the above, the return rate is consider ed sufficiently high. This is in consonance with 70% return rate benchmark suggested by some researchers for example Kathari, (2011)." 2906 3370 W2922435762.pdf 4 68 separator 0.9955825 ¶ ¶ 3371 3377 W2922435762.pdf 4 69 title 0.99025965 Data Presentation 3377 3395 W2922435762.pdf 4 70 separator 0.99266744 ¶ 3396 3398 W2922435762.pdf 4 71 text 0.99839795 "This data presentatio n section is divided into two subsections. The first subsection deals with demographic profile of the respondents. The second subsection deals with the presentation of responses on core subject matter." 3398 3635 W2922435762.pdf 4 72 separator 0.9966693 ¶ 3637 3639 W2922435762.pdf 4 73 title 0.9890129 Demographic Profile of Respondents 3639 3674 W2922435762.pdf 4 74 separator 0.9746704 ¶ 3675 3677 W2922435762.pdf 4 75 text 0.97515804 "Table 3 gives an o verview of the demographic and socioeconomic characteristics of the sample" 3677 3774 W2922435762.pdf 4 76 separator 0.98404455 ¶ 3775 3777 W2922435762.pdf 4 77 title 0.9308429 Table 3: Demographic profile of the sample 3777 3820 W2922435762.pdf 4 78 table 0.7646515 3822 3823 W2922435762.pdf 4 79 separator 0.56982493 ¶ 3823 3824 W2922435762.pdf 4 80 table 0.994327 "Frequency Percentage (%) Cumulative Percent ¶ 180 60.0 60.0 120 40.0 100.0 ¶ 164 54.7 54.7 80 26.7 81.3 56 18.7 100.0" 3825 3964 W2922435762.pdf 4 81 separator 0.95045614 ¶ 3965 3967 W2922435762.pdf 4 82 paratext 0.93259984 "International Journal of Trend in Scientific Resear ch and Development (IJTSRD) ISSN: 2456 -6470 Oct 2018 Page: 1502" 3967 4091 W2922435762.pdf 4 83 title 0.9884255 Table 2: Economic a priori expectation 4092 4131 W2922435762.pdf 4 84 separator 0.9629967 ¶ 4133 4135 W2922435762.pdf 4 85 table 0.8961142 "Expected Relations hips Expecte d Coeffici ents (+/-)" 4135 4207 W2922435762.pdf 4 86 math 0.4927695 0 < 4207 4211 W2922435762.pdf 4 87 table 0.48950225 β 4211 4213 W2922435762.pdf 4 88 math 0.7068922 "0 > 0 + β1 < 0 + β2 < 0 + Β3 < 0 + β4 < 0 + β5 < 0" 4213 4281 W2922435762.pdf 4 89 table 0.33996934 4282 4283 W2922435762.pdf 4 90 separator 0.37707704 ¶ 4283 4284 W2922435762.pdf 4 91 table 0.47114295 Source: 4284 4292 W2922435762.pdf 4 92 text 0.38402703 Researchers 4292 4304 W2922435762.pdf 4 93 table 0.5248579 compilation 4304 4316 W2922435762.pdf 4 94 separator 0.96865207 ¶ 4318 4320 W2922435762.pdf 4 95 text 0.9970276 "A positive '+' sign indicate that the relationship or and regress and is direct and me direction i.e. increase or decrease together. On the other hand, a ' -' shows that there is an indirect (inverse) relationship between the regress or and i.e. they move in opposite or different" 4320 4618 W2922435762.pdf 4 96 separator 0.9397125 ¶ 4619 4621 W2922435762.pdf 4 97 title 0.99313265 DATA PRESENTATION AND ANALYSIS 4621 4652 W2922435762.pdf 4 98 separator 0.6415465 ¶ 4654 4656 W2922435762.pdf 4 99 title 0.9860992 ration and Collection of Instrument 4656 4692 W2922435762.pdf 4 100 separator 0.982877 ¶ 4694 4696 W2922435762.pdf 4 101 text 0.9949981 "The total number of questionnaire distributed was 400. This was determined by the sample size of the study. The number returned was a total of 300copies , representing 75% (percent) of number distributed. the number not returned was 100 (25%). Based the above, the return rate is consider ed sufficiently high. This is in consonance with 70% return rate benchmark suggested by some researchers" 4696 5111 W2922435762.pdf 4 102 separator 0.57165915 ¶ 5113 5115 W2922435762.pdf 4 103 text 0.98024285 "n section is divided into two subsections. The first subsection deals with demographic profile of the respondents. The second subsection deals with the presentation of responses on Demographic Profile of Respondents verview of the demographic and socioeconomic characteristics of the sample ." 5115 5428 W2922435762.pdf 4 104 separator 0.98295283 ¶ 5428 5430 W2922435762.pdf 4 105 table 0.9938755 "Cumulative Percent 60.0 100.0 54.7 81.3 100.0" 5430 5496 W2922435762.pdf 4 0 paratext 0.9856099 154 G.C.HARTMANN ANDO.E.ROSSLER 0 31 W1990833660.pdf 1 1 separator 0.9930643 ¶ 31 33 W1990833660.pdf 1 2 text 0.9968855 "autocatalytically whenever xn,themomentary valueofthechaotic forcing, exceeds thethreshold valueassumed. Thesmallparameter e>0prevents thesecond variable from reaching unrealistic unbounded flareamplitudes. Figure 2shows a simulation." 33 278 W1990833660.pdf 1 3 separator 0.9811539 ¶ 278 280 W1990833660.pdf 1 4 text 0.99910414 "Figure 2(a) isself-explanatory: Thename ""flares"" isdirectly applicable totheelements ofsuchatime series. Thex,bplot(Fig.2(b)) is alsocharacteristic: Ifonewaitslongenough, a screen-filling black ""curtain"" iseventually obtained. Inthetransient picture shown here,the exponentially decreasing density, towards thetop oftheattractor, makes itselfmanifest totheeye." 280 653 W1990833660.pdf 1 5 separator 0.75018114 ¶ 653 655 W1990833660.pdf 1 6 text 0.99787813 "Forcuriosity's sake,wealsopresent, inFig.3,a moresophisticated flareattractor. Itisgenerated decay" 655 758 W1990833660.pdf 1 7 separator 0.9938856 ¶ 758 760 W1990833660.pdf 1 8 caption 0.99619156 "FIGURE Basicmode ofaction ofaflare attractor. A chaotic subsystem ""forces"" anonlinearly responding autocata- lyticunit(schematic drawing)." 760 903 W1990833660.pdf 1 9 separator 0.99040884 ¶ 903 905 W1990833660.pdf 1 10 caption 0.9913239 "FIGURE 2Asimple flareattractor based onthelogistic difference equation: Numerical simulation ofEq.(1).(a)Time plotoftheflaring variable, b.Hereby successive points were connected byastraight linesegment. (b)Sideview(x,bplot)." 905 1137 W1990833660.pdf 1 11 separator 0.9585068 ¶ 1137 1139 W1990833660.pdf 1 12 text 0.90108675 "Parameter values: threshold=0.7, e=0.01. Initial conditions: x=0,b1.Iteration number: 2000for(a);and1000000 for(b).Thisandallfollowing calculations weredone at16- digitprecision." 1139 1324 W1990833660.pdf 1 13 caption 0.975952 "FIGURE 3Flare attractor generated byaninvertible map, Eq.(2).(a)Timebehavior asinFig.2(a),butlonger. (b)Side view(x,bplot)asinFig.2(b).(c)Cross-view (y,bplot).A cross section between x=0andx isshown (" 1324 1530 W1990833660.pdf 1 14 text 0.86172503 "note thatno narrower sliceisnecessary withthisparticular map)." 1530 1594 W1990833660.pdf 1 15 caption 0.4852132 1594 1595 W1990833660.pdf 1 16 text 0.66215 "1000000 iterations areshown (in(b)and(c)). Initial conditions: x0v,Y00.1,b00.1,tend 5000(in(a))." 1595 1695 W1990833660.pdf 1 17 separator 0.9960663 ¶ 1695 1697 W1990833660.pdf 1 0 paratext 0.9886303 Foods 2024 ,13, 924 13 of 15 0 28 W4392958117.pdf 12 1 separator 0.98698455 ¶ 28 30 W4392958117.pdf 12 2 title 0.9877265 4. Conclusions 30 45 W4392958117.pdf 12 3 separator 0.995458 ¶ 45 47 W4392958117.pdf 12 4 text 0.9993651 "The present study demonstrated that Lpb. plantarum A72 possesses significant antiox- idant, anti-aging and longevity extension effects. These effects are due to the probiotic (including the antioxidant action) of the strain. This was demonstrated by the fact that the IC and CFS of this strain scavenged 60.14% and 87.01% of DPPH and hydroxyl rad- icals, respectively, while showing good growth capacity in 0–9 mM H 2O2. By feeding C. elegans with Lpb. plantarum A72, we observed that C. elegans lifespan was extended by 25.13%, motility was enhanced 2.52-fold, and its reproductive ability was not impaired. Lpb. plantarum A72 reduced 34.86% of ROS and 69.52% of MDA in C. elegans and significantly increased the activities of related antioxidant enzymes. The strain enhanced C. elegans survival by 46.33% and 57.78% in high temperature and H 2O2, respectively. Through transcriptomics, it was found that the strain could achieve the effect of anti-aging and prolonging lifespan of C. elegans by upregulating the sod-5 andhsp-16.1 genes and downreg- ulating the fat-6 andlips-17 genes. Therefore, Lpb. plantarum A72 is an effective antioxidant and anti-aging strain. In the future, Lpb. plantarum A72 may be expected to be used in the fermentation of food and other fields. The strain provides for the development of antioxidant functional foods." 47 1425 W4392958117.pdf 12 5 separator 0.9930066 ¶ 1425 1427 W4392958117.pdf 12 6 bibliography 0.66454893 "Supplementary Materials: The following supporting information can be downloaded at: https://www. mdpi.com/article/10.3390/foods13060924/s1" 1427 1568 W4392958117.pdf 12 7 separator 0.7107411 1568 1569 W4392958117.pdf 12 8 bibliography 0.4131987 , 1569 1570 W4392958117.pdf 12 9 caption 0.9645695 "Figure S1: Results of ARTP mutagenesis selection of Lpb. plantarum SC3 as the parent strain. (A) ARTP mutagenesis lethality curve. (B) The growth results of 149 mutant strains and Lpb. plantarum SC3 in MRS broth with 1.5 mM H 2O2. The color of the heatmap indicates the OD 600value of the strains after 20 h in MRS broth with 1.5 mM H 2O2, and the redder the color, the better the growth. Figure S2: Beneficence and growth curve of Lpb. plantarum A72. (A) Survival of Lpb. plantarum A72 cultured for 4 h in MRS broth at pH = 3.0, MRS broth with a bile salt concentration of 0.3% ( w/v), artificial gastric fluid and artificial intestinal fluid. (B) Growth curves of Lpb. plantarum A72 in different concentrations of H 2O2MRS broth.aLpb. plantarum A72" 1570 2335 W4392958117.pdf 12 10 separator 0.7563323 ¶ 2335 2337 W4392958117.pdf 12 11 text 0.86438483 "was tolerant to acid, bile salts, artificial intestinal fluid and gastric fluid environments and the four tolerances were not significant." 2337 2478 W4392958117.pdf 12 12 separator 0.9961494 ¶ 2478 2480 W4392958117.pdf 12 13 bibliography 0.99262154 "Author Contributions: S.Z. (Sibo Zou): Formal Analysis, Investigation, Writing—Original Draft, Writing—Reviewing and Editing. Q.W.: Methodology, Investigation. Z.L.: Validation, Data Curation." 2480 2675 W4392958117.pdf 12 14 separator 0.76370937 ¶ 2675 2677 W4392958117.pdf 12 15 bibliography 0.979274 "S.Z. (Sufang Zhang): Writing—Reviewing and Editing. L.D.: Resources. Y.C.: Resources. Y.D.: Resources. C.J.: Resources. H.L.: Conceptualization, Supervision, Project Administration. X.L.: Conceptualization, Supervision, Project Administration. All authors have read and agreed to the published version of the manuscript." 2677 3004 W4392958117.pdf 12 16 separator 0.9911376 ¶ 3004 3006 W4392958117.pdf 12 17 text 0.9342732 "Funding: This research was funded by the National Key Research and Development Project (2023YFD2100304), the High-Level Talents Innovation and Entrepreneurship Project of Dalian (2021RQ093) and the Basic Research Project of the Education Department of Liaoning Province (LJKZ0544)." 3006 3294 W4392958117.pdf 12 18 separator 0.9922271 ¶ 3294 3296 W4392958117.pdf 12 19 paratext 0.40490913 Institutional Review Board Statement: Not applicable. 3296 3350 W4392958117.pdf 12 20 separator 0.87861747 ¶ 3350 3352 W4392958117.pdf 12 21 paratext 0.4004037 Informed Consent Statement: Not 3352 3384 W4392958117.pdf 12 22 text 0.37369615 applicable 3384 3395 W4392958117.pdf 12 23 paratext 0.43475246 . 3395 3396 W4392958117.pdf 12 24 separator 0.92448235 ¶ 3396 3398 W4392958117.pdf 12 25 text 0.3994736 Data 3398 3404 W4392958117.pdf 12 26 paratext 0.36649486 Availability 3404 3416 W4392958117.pdf 12 27 text 0.6888241 "Statement: The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors." 3416 3595 W4392958117.pdf 12 28 separator 0.9650322 ¶ 3595 3597 W4392958117.pdf 12 29 paratext 0.4030695 Conflicts of Interest: The 3597 3624 W4392958117.pdf 12 30 text 0.43974993 authors declar 3624 3639 W4392958117.pdf 12 31 paratext 0.4457862 e 3639 3640 W4392958117.pdf 12 32 text 0.43460155 no conflict of interest 3640 3664 W4392958117.pdf 12 33 paratext 0.4682396 . 3664 3665 W4392958117.pdf 12 34 separator 0.9948772 ¶ 3665 3667 W4392958117.pdf 12 35 title 0.79688394 References 3667 3678 W4392958117.pdf 12 36 separator 0.985829 ¶ 3678 3680 W4392958117.pdf 12 37 bibliography 0.99757713 "1. Guedj, A.; Volman, Y.; Geiger-Maor, A.; Bolik, J.; Schumacher, N.; Künzel, S.; Baines, J.F.; Nevo, Y.; Elgavish, S.; Galun, E.; et al. Gut microbiota shape ‘inflamm-ageing’ cytokines and account for age-dependent decline in DNA damage repair. Gut2020 ,69, 1064–1075. [CrossRef] [PubMed]" 3680 3974 W4392958117.pdf 12 38 separator 0.7888958 ¶ 3974 3976 W4392958117.pdf 12 39 bibliography 0.99343514 "2. He, M.; Chiang, H.H.; Luo, H.; Zheng, Z.; Qiao, Q.; Wang, L.; Tan, M.; Ohkubo, R.; Mu, W.C.; Zhao, S. An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance. Cell Metab. 2020 ,31, 580–591. [CrossRef] [PubMed]" 3976 4256 W4392958117.pdf 12 0 paratext 0.96710914 "ORIGINAL RESEARCH published: 19 December 2018 doi: 10.3389/fnins.2018.00950 Frontiers in Neuroscience | www.frontiersin.org 1 December 2018 | Volume 12 | Article 950" 0 171 W2903770715.pdf 0 1 contact 0.9781631 "Editedby: AndrewL.Alexander, UniversityofWisconsin-Madison, UnitedStates Reviewedby: AndreaMartinuzzi, EugenioMedea(IRCCS),Italy JodieReannaGawryluk, UniversityofVictoria,Canada *Correspondence: LauraChaddock-Heyman lchaddo2@illinois.edu" 171 430 W2903770715.pdf 0 2 separator 0.94785345 ¶ 430 432 W2903770715.pdf 0 3 paratext 0.9254086 "Specialtysection: Thisarticlewassubmittedto BrainImagingMethods, asectionofthejournal FrontiersinNeuroscience Received: 31August2018 Accepted: 30November2018 Published: 19December2018" 432 630 W2903770715.pdf 0 4 separator 0.98241067 ¶ 630 632 W2903770715.pdf 0 5 paratext 0.88322043 Citation: 632 642 W2903770715.pdf 0 6 separator 0.9427012 ¶ 642 644 W2903770715.pdf 0 7 bibliography 0.7223284 "Chaddock-HeymanL,EricksonKI, KienzlerC,DrolletteES,RaineLB, KaoS-C,BenskenJ,WeisshappelR, CastelliDM,HillmanCHand " 644 765 W2903770715.pdf 0 8 separator 0.50047654 ¶ 765 766 W2903770715.pdf 0 9 bibliography 0.7665977 KramerAF 766 775 W2903770715.pdf 0 10 paratext 0.6119359 "(2018)PhysicalActivity IncreasesWhiteMatterMicrostructure" 775 834 W2903770715.pdf 0 11 separator 0.47404814 ¶ 834 836 W2903770715.pdf 0 12 paratext 0.7724236 inChildren.Front.Neurosci.12:950. 836 870 W2903770715.pdf 0 13 separator 0.6836213 ¶ 870 872 W2903770715.pdf 0 14 paratext 0.78925633 doi:10.3389/fnins.2018.00950Physical 872 909 W2903770715.pdf 0 15 title 0.9056667 "Activity Increases White Matter Microstructure in Children" 909 970 W2903770715.pdf 0 16 separator 0.99493635 ¶ 970 972 W2903770715.pdf 0 17 contact 0.41955695 Laura 972 978 W2903770715.pdf 0 18 table 0.44410056 Chad 978 982 W2903770715.pdf 0 19 contact 0.42546424 dock-Heyman 982 993 W2903770715.pdf 0 20 table 0.5507735 1*, 993 996 W2903770715.pdf 0 21 contact 0.46440136 KirkI 996 1001 W2903770715.pdf 0 22 table 0.57111645 . 1001 1002 W2903770715.pdf 0 23 contact 0.46240467 Er 1002 1004 W2903770715.pdf 0 24 table 0.55355453 ickson2,C 1004 1013 W2903770715.pdf 0 25 contact 0.5095072 aitlinKi 1013 1021 W2903770715.pdf 0 26 table 0.55158556 enzler3, 1021 1029 W2903770715.pdf 0 27 contact 0.5114857 EricS 1029 1034 W2903770715.pdf 0 28 table 0.544628 . 1034 1035 W2903770715.pdf 0 29 contact 0.47597024 Droll 1035 1040 W2903770715.pdf 0 30 table 0.5698274 "ette4, LaurenB.Raine5,Shih-" 1040 1069 W2903770715.pdf 0 31 contact 0.43975312 Chun 1069 1073 W2903770715.pdf 0 32 table 0.6160988 "Kao5,JeanineBensken6,RobertWeisshappel1, DarlaM.Castelli7,CharlesH.Hillman5,8andArthurF.Kramer" 1073 1169 W2903770715.pdf 0 33 contact 0.5248857 1,5 1169 1172 W2903770715.pdf 0 34 separator 0.9937639 ¶ 1172 1174 W2903770715.pdf 0 35 contact 0.98198986 "1BeckmanInstitute,UniversityofIllinoisatUrbana-Champai gn,Urbana,IL,UnitedStates,2DepartmentofPsychology, UniversityofPittsburgh,Pittsburgh,PA,UnitedStates,3DepartmentofPsychology,UniversityofColorado,Denver, CO, UnitedStates,4DepartmentofKinesiology,UniversityofNorthCarolinaat Greensboro,Greensboro,NC,UnitedStates," 1174 1496 W2903770715.pdf 0 36 separator 0.6242991 ¶ 1496 1498 W2903770715.pdf 0 37 contact 0.9722441 "5DepartmentofPsychology,NortheasternUniversity,Bosto n,MA,UnitedStates,6DepartmentofKinesiologyand CommunityHealth,UniversityofIllinoisatUrbana-Champai gn,Urbana,IL,UnitedStates,7DepartmentofKinesiologyand HealthEducation,TheUniversityofTexasatAustin,Austin ,TX,UnitedStates,8DepartmentofPhysicalTherapy,Movement, &RehabilitationSciences,NortheasternUniversity,Bost on,MA,UnitedStates" 1498 1889 W2903770715.pdf 0 38 separator 0.99492264 ¶ 1889 1891 W2903770715.pdf 0 39 text 0.99919397 "Children are becoming increasingly inactive, unfit, and ove rweight, yet there is relatively little causal evidence regarding the effects of physical ac tivity on brain health during childhood. The present study examined the effects of an afte r-school physical activity program (FITKids2) on the microstructure of white matter tr acts in 7- to 9-year-old children.Wemeasuredthemicrostructuralpropertiesofwh itematterviadiffusiontensor imaging in 143 children before and after random assignment t o either a 9-month after-school physical activity program ( N=76, mean age =8.7 years) or a wait list control group ( N=67, mean age =8.7 years). Our results demonstrate that children who participated in the physical activity program showed increased white matter microstructure in the genu of the corpus callosum, wi th no changes in white matter microstructure in the wait list control group which r eflects typical development." 1891 2837 W2903770715.pdf 0 40 separator 0.81660247 ¶ 2837 2839 W2903770715.pdf 0 41 text 0.9994856 "Specifically, children in the physical activity program sho wed increases in fractional anisotropy (FA) and decreases in radial diffusivity (RD) in the genu from pre- to post-test, thereby suggesting more tightly bundled and structurally c ompact fibers (FA) and increased myelination (RD), with no changes in estimates of axonal fiber diameter (axial diffusivity,AD).Thecorpuscallosumintegratescognitiv e,motor,andsensoryinformation between the left and right hemispheres of the brain, and the w hite matter tract plays a role in cognition and behavior. Our findings reinforce the im portance of physical activity for brain health during child development." 2839 3507 W2903770715.pdf 0 42 separator 0.9908747 ¶ 3507 3509 W2903770715.pdf 0 43 text 0.54048294 Keywords: brain deve, children, physical activity, diffusi 3509 3568 W2903770715.pdf 0 44 paratext 0.31491736 on 3568 3571 W2903770715.pdf 0 45 text 0.3942881 tensor imaging, white 3571 3593 W2903770715.pdf 0 46 paratext 0.373254 matter 3593 3600 W2903770715.pdf 0 47 separator 0.99659234 ¶ 3600 3602 W2903770715.pdf 0 48 title 0.98740417 INTRODUCTION 3602 3615 W2903770715.pdf 0 49 separator 0.99505746 ¶ 3615 3617 W2903770715.pdf 0 50 text 0.9991467 "Children are becoming increasingly inactive, unfit, and over weight. Exercise has decreased in school-aged youth, with only one-quarter of children partic ipating in the recommended 60min or more of moderate-to-vigorous physical activity per day ( National Physical Activity Plan Alliance, 2016 ). Schools, which reach ∼55.5 million children between the ages of 5 and 17 years (National Center for Education Statistics, U.S. Department of Education, 2017 ), have contributed" 3617 4099 W2903770715.pdf 0 0 paratext 0.90578204 Anna NOWAKOWSKA-GŁUSZAK, Funkcja rodzajnika w okre laniu adresata... 0 66 W2590567695.pdf 4 1 separator 0.8335522 ¶ 67 69 W2590567695.pdf 4 2 bibliography 0.64682287 p 69 71 W2590567695.pdf 4 3 text 0.87339675 ostrzeganymi jako konkretne jednostki 71 108 W2590567695.pdf 4 4 bibliography 0.4747777 108 109 W2590567695.pdf 4 5 text 0.9224978 a tymi, 109 116 W2590567695.pdf 4 6 bibliography 0.45400113 116 117 W2590567695.pdf 4 7 text 0.8504361 "o kt órych my limy w kategoriach pewnego rodzaju czy gatunku" 117 180 W2590567695.pdf 4 8 bibliography 0.7688158 ” (Pawlik 2001, 48)8. 180 201 W2590567695.pdf 4 9 separator 0.9920647 ¶ 202 204 W2590567695.pdf 4 10 text 0.9965599 "Na potrzeby niniejszej analizy i zgodnie z jej zało eniami badawczymi, traktowa bdziemy rodzajnik jako jednostk formaln jzyka uywan w funkcji semantycznej (por. Karolak 2001, 337)." 204 394 W2590567695.pdf 4 11 separator 0.99724144 ¶ 396 398 W2590567695.pdf 4 12 title 0.9938761 5.2. Rodzajnik w tekstach prawnych 398 433 W2590567695.pdf 4 13 separator 0.99644786 ¶ 433 435 W2590567695.pdf 4 14 text 0.9995066 "W literaturze specjalistycznej na temat hiszpa skiego j zyka prawa, rodzajnikowi nie powicono zbyt wiele uwagi. I tak Hernando Cuadrado opisuj c poziom morfo- syntaktyczny hiszpa skich tekstów prawnych stwierdza: „rodzajnik [okre lony] cz sto nadaje warto generyczn wprowadzaj c rzeczowniki, które nie odnosz si do indywidualnych osób ani konkretnych rzeczy” (2003, 15), i „rodzajnik nieokre lony un, wraz z czasownikiem w formie futuro imperfecto de indicativo czasami wskazuje, e referent syntagmy lub grupy nominalnej, któr poprzedza, nie istnieje w momencie formułowania wypowiedzi, ale mo e zaistnie w przyszło ci” (2003, 15-16). Opis ten, z oczywistych powodów, wydaje si mało satysfakcjonuj cy z perspektywy polskiego odbiorcy." 435 1202 W2590567695.pdf 4 15 separator 0.994205 ¶ 1204 1206 W2590567695.pdf 4 16 text 0.91603273 "Spróbujmy przeanalizowa problem na przykładzie wybranych artykułów z hiszpa skiego kodeksu cywilnego:" 1206 1312 W2590567695.pdf 4 17 separator 0.9435077 ¶ 1313 1315 W2590567695.pdf 4 18 text 0.96225613 "1. ............. extranjero menor de dieciocho años adoptado por un español adquiere, desde la adopción, la nacionalidad españo la de origen. (Art. 19) 2. .............. hijo, al alcanzar la mayor edad, podrá solicitar que se altere el orden de los apellidos. (Art. 109)" 1315 1598 W2590567695.pdf 4 19 separator 0.5011493 ¶ 1599 1601 W2590567695.pdf 4 20 text 0.97336817 "3. ........... menor no emancipado ejercerá la pat ria potestad sobre sus hijos con la asistencia de sus padres y, a falta de ambos, de su tutor; en casos de desacuerdo o imposibilidad, con la del Juez. (Art. 157)" 1601 1822 W2590567695.pdf 4 21 separator 0.7143986 ¶ 1823 1825 W2590567695.pdf 4 22 text 0.8875972 "4. Si....................... usuario consumiera todos los frutos de la cosa ajena, o el que tuviere derecho de habitación ocupara toda la casa, estará obligado a los gastos de cultivo, a los reparos ordinarios de cons ervación y al pago de las contribuciones, del mismo modo que el usufructuario. (Art. 527)" 1825 2143 W2590567695.pdf 4 23 separator 0.9938186 ¶ 2144 2146 W2590567695.pdf 4 24 text 0.9986278 "Co przemawia za u yciem rodzajnika okre lonego, nieokre lonego b d zerowego w powy szych zdaniach? Jakim kryterium powinien kierowa si nasz student? By odpowiedzie na to pytanie, oprzemy si na podr czniku uniwersyteckim Selección de problemas de gramática española, skierowanym, jak zauwaa w przedmowie sam autor, Janusz Pawlik, do neofilo logów. Skupimy si na syntagmach nominalnych (SN) reprezentowanych przez nasze przykłady, tj. prostych lub złoonych, w których rzeczownik ma liczb pojedyncz , jest nazw ogóln" 2146 2683 W2590567695.pdf 4 25 separator 0.88653994 ¶ 2683 2685 W2590567695.pdf 4 26 paratext 0.6969229 8 Wszystkie tłumaczenia z j zyka hiszpa skiego wykonała autorka. 2685 2750 W2590567695.pdf 4 0 paratext 0.9892876 AppliedChem 2022 ,2 40 0 22 W4214885647.pdf 10 1 separator 0.995853 ¶ 22 24 W4214885647.pdf 10 2 title 0.9257284 Table 3. MMD of derivatized PB lignin from universal calibration with global curve fit and individual 24 125 W4214885647.pdf 10 3 separator 0.9926585 ¶ 125 127 W4214885647.pdf 10 4 caption 0.57674533 curve fit and comparison with standard calibration. (M values in g mol 127 197 W4214885647.pdf 10 0 paratext 0.9802272 "www.ccsenet.org/jms Journal of Management and Sustainability V ol. 2, No. 2; 2012 230" 0 88 W2101725293.pdf 3 1 separator 0.9639466 ¶ 89 91 W2101725293.pdf 3 2 title 0.9930569 4. Childhood Diseases: The Yoruba Traditional Perspective 92 150 W2101725293.pdf 3 3 separator 0.9956639 ¶ 151 153 W2101725293.pdf 3 4 text 0.9997143 "The study area is Lagos State, Nigeria which is one of the six states in South-West Nigeria and predominantly inhabited by the Yoruba. Ogunjuyigbe (2004) explained that despite the fact that major childhood diseases have been identified by modern technology, yet, children from African countries die in large number from attack of these diseases because of the deep rooted beliefs and attitudes of the people concerning childcare and behavioural practices in health strategies. The Yoruba perceptions about the aetiology of most childhood diseases are a great hindrance to public health programmes and intervention by the government of Nigeria. Adegoke (2008) while explaining the f actors influencing health beliefs am ong the people of South-West Nigeria conceded that African conception of illness and disease ca usation are often linked with the belief that misfortune of which ill health is a form does not happen by chance. Quoting Odebiyi (1980), he explained that in Yoruba society, people attribute diseases and illnesses to supe rnatural causes. Odebiyi & Ekong (1982) in Ogunjuyigbe (2004) corroborated this point when he observed that in traditional Yoruba setting, measles attack is usually attributed to a variety of causes which have no link with the concept of virus, According to him, measles attack is considered to be punishment for breaking family taboo or evil deed from witches or enemies or the consequence of rivalry between co-wives in a polygamous setting." 153 1666 W2101725293.pdf 3 5 separator 0.97782326 ¶ 1668 1670 W2101725293.pdf 3 6 text 0.9996931 "To the Yoruba, measles is the by-product of the anger of Igbona or Sopona or Olode, the god of small-pox (Odebiyi & Ekong, 1982). This god is known to be intolerant of any form of vaccination or injection and it is generally believed among the Yoruba of South-West Nigeria that a child having measles should neither visit the hospital nor take injection." 1670 2036 W2101725293.pdf 3 7 separator 0.9308699 ¶ 2037 2039 W2101725293.pdf 3 8 text 0.9996884 "Tuberculosis on the other hand is seen by the Yoruba to be an affliction resulting from food ate in a dream or poisoning from enemies who have access to the victims’ saliva. In this respect children and adults alike are usually warned not to spit on the sand or leave their chew ing stick or toothbrushes in places where enemies could have access to them." 2039 2405 W2101725293.pdf 3 9 separator 0.9729494 ¶ 2407 2409 W2101725293.pdf 3 10 text 0.99967265 "Asakitikpi (2004) observed that diarrhoea is seen among the Yoruba as a type of illness that is generally regarded as a milestone in the development of the child below five years. According to him, most mothers believe that diarrhoea signifies the onset of growing of teeth by babies while some see the disease as being caused by consumption of sweet" 2409 2770 W2101725293.pdf 3 11 separator 0.9937881 ¶ 2771 2773 W2101725293.pdf 3 12 title 0.9889762 5. Methodology 2773 2788 W2101725293.pdf 3 13 separator 0.9963752 ¶ 2789 2791 W2101725293.pdf 3 14 text 0.99969035 "The population of this study consists of all mothers in Lagos State, Nigeria. The quota sampling techniques was considered appropriate here to give the study the desired spread across the local government areas (LGAs) and also because a sampling frame is not readily availa ble. However, the state was divided into the 20 constitutionally recognised Local Govern ment Areas (LGAs) and pa rents (fathers and moth ers) were selected and interviewed on the spot (that is, wher ever they were found to be present)." 2791 3312 W2101725293.pdf 3 15 separator 0.8670671 ¶ 3313 3315 W2101725293.pdf 3 16 text 0.99917394 "A sample of 1000 respondents spread across the 20 LGAs was interviewed. The instrument which consists of 35 questions .was tested for pilot tested before being sent to the field. Variables examined include demographic details such as Gender; Age; Marital Status; Religion; Educational qualifications; Occupation and so on. Other details such as: Whether their children were immunise d or not; How many of their children were immunised?; Whether they found immunisation beneficial; Type of immunisation; Opinion about Immunisation and so on were also considered in the study." 3315 3903 W2101725293.pdf 3 17 separator 0.84462154 ¶ 3904 3906 W2101725293.pdf 3 18 text 0.99937296 "Apart from descriptive analysis which includes frequency distribution and percentages, hypotheses were also tested at 5 % level of significance to ascertain the dependence of the various attributes (variables) in our study using the 2 statistics. This statistical tool was found to be appropriate in this case because the variables in the study are categorical." 3906 4282 W2101725293.pdf 3 19 separator 0.9971159 ¶ 4283 4285 W2101725293.pdf 3 20 title 0.9875462 6. Results 4285 4296 W2101725293.pdf 3 21 separator 0.9950378 ¶ 4297 4299 W2101725293.pdf 3 22 title 0.9902668 6.1 Data Description 4299 4320 W2101725293.pdf 3 23 separator 0.99602604 ¶ 4321 4323 W2101725293.pdf 3 24 text 0.9997109 "About 70 percent of the respondents are females. The study did not preclude the male parents because of their overbearing influence on decisions about the children and this may include decision on whether to immunise such child or not. Slightly over 72 percent of the respondents are married while 8 percent are separated from their spouses and 4.1 percent are divorced. In terms of educational attainment, more than 50 percent of the respondents are graduates from Polytechnics and Univ ersities while 29.2 percent possess Secondary School Certificates and below." 4323 4894 W2101725293.pdf 3 0 paratext 0.98529184 Processes 2020 ,8, 1001 14 of 14 0 32 W3049590720.pdf 13 1 separator 0.99202156 ¶ 32 34 W3049590720.pdf 13 2 bibliography 0.9979233 "14. Bartczak, P .; Norman, M.; Klapiszewski, L.; Karwan’ska, N.; Kawalec, M.; Baczyn ́ska, M.; Wysokowski, M.; Zdarta, J.; Ciesielczyk, F.; Jesionowski, T. Removal of nickel(II) and lead(II) ions from aqueous solution using peat as a low-cost adsorbent: A kinetic and equilibrium study. Arab. J. Chem. 2018 ,11, 1209–1222. [CrossRef]" 34 372 W3049590720.pdf 13 3 separator 0.95792454 ¶ 372 374 W3049590720.pdf 13 4 bibliography 0.99794024 "15. Ali, I.H.; Al Mesfer, M.K.; Khan, M.I.; Danish, M.; Alghamdi, M.M. Exploring Adsorption Process of Lead (II) and Chromium (VI) Ions from Aqueous Solutions on Acid Activated Carbon Prepared from Juniperus procera Leaves. Processes 2019 ,7, 217. [CrossRef]" 374 637 W3049590720.pdf 13 5 separator 0.9406991 ¶ 637 639 W3049590720.pdf 13 6 bibliography 0.9981011 "16. Chang, C.F.; Chang, C.Y.; Chen, K.H.; Tsai, W.T.; Shie, J.L.; Chen, Y.H. Adsorption of naphthalene on zeolite from aqueous solution. J. Colloid. Interface Sci. 2004 ,277, 29–34. [CrossRef]" 639 834 W3049590720.pdf 13 7 separator 0.9071589 ¶ 834 836 W3049590720.pdf 13 8 bibliography 0.9979181 "17. Ali, I.H.; Sulfab, Y. Kinetics and mechanism of oxidation of cisdiaquabis(glycinato)chromium(III) by periodate ion in aqueous solutions. Transit. Met. Chem. 2013 ,38, 79–84. [CrossRef]" 836 1027 W3049590720.pdf 13 9 separator 0.9291405 ¶ 1027 1029 W3049590720.pdf 13 10 bibliography 0.9979975 "18. Tempkin, M.I.; Pyzhev, V . Kinetic of Ammonia Synthesis on Promoted Iron Catalyst. Acta Phys. Chim. USSR 1940 ,12, 327–356." 1029 1159 W3049590720.pdf 13 11 separator 0.97072804 ¶ 1159 1161 W3049590720.pdf 13 12 bibliography 0.99801064 "19. Günay, A.; Arslankaya, E.; Tosun, I. Lead removal from aqueous solution by natural and pretreated clinoptilolite: Adsorption equilibrium and kinetics. J. Hazard. Mater. 2007 ,146, 362–371. [CrossRef]" 1161 1367 W3049590720.pdf 13 13 separator 0.9304334 ¶ 1367 1369 W3049590720.pdf 13 14 bibliography 0.99787354 "20. Gupta, S.; Kumar, A. Removal of nickel (II) from aqueous solution by biosorption on A. barbadensis Miller waste leaves powder. Appl. Water Sci. 2019 ,9, 96–107. [CrossRef]" 1369 1547 W3049590720.pdf 13 15 separator 0.9191866 ¶ 1547 1549 W3049590720.pdf 13 16 bibliography 0.9978864 "21. Priyantha, N.; Kotabewatta, P .A. Biosorption of heavy metal ions on peel of Artocarpus nobilis fruit: 1—Ni(II) sorption under static and dynamic conditions. Appl. Water Sci. 2019 ,9, 37–47. [CrossRef]" 1549 1757 W3049590720.pdf 13 17 separator 0.93545663 ¶ 1757 1759 W3049590720.pdf 13 18 bibliography 0.99786013 "22. Gupta, S.; Sharma, S.K.; Kumar, A. Biosorption of Ni(II) ions from aqueous solution using modified Aloe barbadensis Miller leaf powder. Water Sci. Eng. 2019 ,12, 27–36. [CrossRef]" 1759 1944 W3049590720.pdf 13 19 separator 0.94325584 ¶ 1944 1946 W3049590720.pdf 13 20 bibliography 0.99802995 "23. Barquilha, C.E.R.; Cossich, E.S.; Tavares, C.R.; Silva, E.A. Biosorption of nickel(II) and copper(II) ions by Sargassum sp. in nature and alginate extraction products. Bioresour. Technol. Rep. 2019 ,5, 43–50. [CrossRef]" 1946 2172 W3049590720.pdf 13 21 separator 0.94501936 ¶ 2172 2174 W3049590720.pdf 13 22 bibliography 0.99678755 "24. Pandey, P .K.; Choubey, S.; Verma, Y.; Pandey, M.; Kamal, S.S.; Chandrashekhar, K. Biosorptive removal of Ni(Ii) from wastewater and industrial e uent. Int. J. Environ. Res. Public Health 2007 ,4, 332–339. [CrossRef] [PubMed]" 2174 2409 W3049590720.pdf 13 23 separator 0.96491605 ¶ 2409 2411 W3049590720.pdf 13 24 bibliography 0.9979987 "25. Thevannan, A.; Mungroo, R.; Niu, C. Biosorption of nickel with barley straw. Bioresour. Technol. 2010 ,101, 1776–1780. [CrossRef]" 2411 2547 W3049590720.pdf 13 25 separator 0.93265617 ¶ 2547 2549 W3049590720.pdf 13 26 bibliography 0.99804115 "26. Feng, N.; Guo, X.; Liang, S.; Zhu, Y.; Liu, J. Biosorption of heavy metals from aqueous solutions by chemically modified orange peel. J. Hazard. Mater 2011 ,185, 49–54. [CrossRef]" 2549 2734 W3049590720.pdf 13 27 separator 0.9207672 ¶ 2734 2736 W3049590720.pdf 13 28 bibliography 0.9978414 "27. Malkoc, E.; Nuhoglu, Y. Investigations of nickel(II) removal from aqueous solutions using tea factory waste. J. Hazard. Mater 2005 ,127, 120–128. [CrossRef]" 2736 2899 W3049590720.pdf 13 29 separator 0.9070956 ¶ 2899 2901 W3049590720.pdf 13 30 paratext 0.9760014 "©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http: //creativecommons.org /licenses /by/4.0/)." 2901 3146 W3049590720.pdf 13 0 paratext 0.7661612 "Molecules ¶ 2006 , ¶ 11 , ¶ 232 - 241 ¶ molecules ¶ ISSN 1420 - 3049 ¶ http://www.mdpi.org ¶ Co r rection ¶ Publisher " 0 172 W2007907395.pdf 0 1 title 0.44976828 "' s Note " 172 183 W2007907395.pdf 0 2 text 0.28943563 ¶ 183 187 W2007907395.pdf 0 3 paratext 0.3611509 ¶ added 187 194 W2007907395.pdf 0 4 title 0.34870255 on 194 197 W2007907395.pdf 0 5 paratext 0.45636985 29 197 200 W2007907395.pdf 0 6 text 0.41627863 June 200 205 W2007907395.pdf 0 7 paratext 0.45566452 2006 205 210 W2007907395.pdf 0 8 separator 0.81387454 "¶ ¶" 210 220 W2007907395.pdf 0 9 contact 0.97110885 "Shu - K un Lin ¶ MDPI, Matthaeusstrasse 11, CH - 4057 Basel, Switzerland ; E - mail: lin@mdpi.com ¶" 220 348 W2007907395.pdf 0 10 paratext 0.87193096 "Published: 29 ¶ J une ¶ 2006" 348 390 W2007907395.pdf 0 11 separator 0.8094343 "¶ ¶ ¶" 390 404 W2007907395.pdf 0 12 text 0.9603856 "There is a pagination error in this paper. The page number for the first page (Sergei V. Trepalin ¶ et al . ¶ Mo lecules ¶ 2006, 11 , 219) is assigned correctly. However, the following pages were not correctly paginated and the final page number should be 231 instead of 241. The original file is still provided. Pages 232 - 241 are thus taken as blank pages. We apologize f or this error and for any inconvenience ." 404 860 W2007907395.pdf 0 13 separator 0.68655926 ¶ 860 865 W2007907395.pdf 0 14 paratext 0.93016094 "¶ ¶ © 200 6 ¶ by MDPI (http://www.mdpi.org)." 865 921 W2007907395.pdf 0 15 separator 0.5565085 922 923 W2007907395.pdf 0 16 paratext 0.94758844 "¶ This is an open access article distributed under the Creative Commons Attribution License ¶ (CC BY 3.0)." 923 1042 W2007907395.pdf 0 17 separator 0.9947194 ¶ 1042 1044 W2007907395.pdf 0 0 paratext 0.9752943 "783 E-Amal Jurnal Pengabdian Kepada Masyarakat Vol. 02, No. 01, Januari , 2022, pp. 779 -784 ¶ https://stp -mataram.e -journal.id/Amal ISSN: 2774 -8316 (Print), ISSN: 2775 -0302 (Online)" 0 214 W4313373946.pdf 4 1 separator 0.99348706 ¶ 217 219 W4313373946.pdf 4 2 title 0.99014837 KESIMPULAN 219 230 W4313373946.pdf 4 3 separator 0.99446476 ¶ 232 234 W4313373946.pdf 4 4 text 0.9944004 "Peran mahasiswa dalam kehidupan bermasyarakat dan bernegara dalam proses pembangunan dapat dilakukan melalui kegiatan nonakademik dalam bentuk seperti pengabdian kepada masyarakat dalam bentuk pelatihan, edukasi, sosialisasi, penyuluhan. Mahasiswa memiliki peran sebagai agent of change , mengubah cara pandangan kelompok sasaran, berupa edukasi Gemarikan bagaimana cara memelihara ikan air tawar se hingga dapat dikonsumsi sehari -hari dan menambah nilai ekonomi. Kegiatan ini memberikan dampak edukatif karena mahasiswa membantu meningkatkan kesadaran dan pengetahuan berdasarkan materi yang diberikan, dan berdampak sosial karena mahasiswa melaksanakan sebagai agent of sosial change ." 234 948 W4313373946.pdf 4 5 separator 0.9751074 ¶ ¶ 949 955 W4313373946.pdf 4 6 title 0.9896029 ACKNOWLEDGMENTS 955 971 W4313373946.pdf 4 7 separator 0.9932306 ¶ 973 975 W4313373946.pdf 4 8 text 0.99680007 "Tim Abdimas mengucapkan terima kasih kepada LPPM STKIP PGRI Pacitan, tim mahasiswa dari Himaprodi PGSD, dan Duta Gemarikan atas kerjasama dan dukungannya dalam setiap tahap kegiatan ini sehing ga terlaksana dengan baik." 975 1217 W4313373946.pdf 4 9 separator 0.99293685 ¶ ¶ 1219 1225 W4313373946.pdf 4 10 title 0.9861601 DAFTAR REFERENSI 1225 1242 W4313373946.pdf 4 11 separator 0.9951817 ¶ 1244 1246 W4313373946.pdf 4 12 bibliography 0.9943431 "[1] Wibawa, Sutrisna. 2017. Tridharma Perguruan Tinggi (Pendidikan Dan Pengabdian Kepada Masyarakat). 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Piechota, P .; Cronin, M.T.; Hewitt, M.; Madden, J.C. Pragmatic approaches to using computacional methods to predict xenobiotic metabolism. J. Chem. Inf. Model. 2013 ,53, 1282–1293. [CrossRef] [PubMed]" 3118 3326 W2765729209.pdf 24 35 separator 0.9846705 ¶ 3326 3328 W2765729209.pdf 24 36 paratext 0.94190234 Sample Availability: Not Available. 3328 3364 W2765729209.pdf 24 37 separator 0.6952779 ¶ 3364 3366 W2765729209.pdf 24 38 paratext 0.9766707 "©2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)." 3366 3608 W2765729209.pdf 24 0 title 0.62631893 Kunze et al. Arthroscopic Core Decompression for Osteonecrosis 0 62 W4226026819.pdf 2 1 text 0.723443 62 63 W4226026819.pdf 2 2 separator 0.9132272 ¶ 63 64 W4226026819.pdf 2 3 text 0.9838232 "of patient reported outcomes. Future research should determi ne the patient subjective experience following arthroscopic-as sisted coredecompressionforearly-onsetONFH." 64 236 W4226026819.pdf 2 4 separator 0.98971033 ¶ 236 238 W4226026819.pdf 2 5 text 0.9994284 "Guo et al. ( 21) performed a randomized controlled trial where patients with Ficat grade II ONFH were treated with arthroscopic-guided core decompression and bone grafting combined with selective arterial infusion (experimental gr oup, n=35) or percutaneous core decompression combined with selective arterial infusion (control group, n=41). At a mean 30-month follow-up, the mean Harris Hip Score (HHS) was significantly greater in the experimental group compared with the control group (86.7 vs. 78.6, p<0.05), despite similar reported HHS preoperatively. They also reported that the change in the radiographic appearance of the femoral head was significantly better in the experimental group. Although both treatment methods are effective, the authors concluded that arthroscopic-guided core decompression can obtain bett er results as the necrotic femoral head can be positioned and scrapedmoreaccurately." 238 1175 W4226026819.pdf 2 6 separator 0.99426115 ¶ 1175 1177 W4226026819.pdf 2 7 text 0.99947685 "Ellenrieder et al. ( 19) reported the outcomes of 53 patients (56 hips) with Steinberg grade 0-IVa ONFH treated with arthroscopically-assisted core decompression. At a mean 33- month follow-up, the success rate (defined as no conversion to THA, no reoperations, or no radiological progression of OFNH with clinical symptoms) was 86%. Of the nine failures, the majority were in stage IVa (31%) and stage III (25%) patients. These results support the indication of utilizing arthroscopic-assisted core decompression in late-stage ONF H with increased risk of failure and/or progression to THA." 1177 1786 W4226026819.pdf 2 8 separator 0.99167377 ¶ 1786 1788 W4226026819.pdf 2 9 text 0.99949586 "Additionally, we would like to introduce the case of a 46-yea r- old female who presented to our service with early subchondral collapse and subsequently underwent core decompression and labral debridement, the need for the latter of which was identifiedduringthediagnosticarthroscopy.Thepatientrem ains free of major complication at the 2-year follow-up point as defined by any revision procedures or progression to THA. Such cases bolster the need for further research on the efficacy of core decompression in patients with more advancedAVN." 1788 2346 W4226026819.pdf 2 10 separator 0.99468756 ¶ 2346 2348 W4226026819.pdf 2 11 text 0.99944025 "Guadilla et al. ( 20) studied the use of arthroscopic-assisted core decompression and platelet-rich plasma (PRP) therapy in four patients with pre-collapse ONFH. At a mean 14-month follow-up, all patients reported a reduction in pain intensity and returned to their “normal style of life” by 5 months.Two patients were found to have labral tears and were treated with debridement. The authors noted that this procedure may improve the overall diagnostic accuracy of labrum degenerati on or other pathologies in patients with ONFH when not identified on MRI and also allows for precise decompression due to enhancedvisualcontrol." 2348 2994 W4226026819.pdf 2 12 separator 0.9938347 ¶ 2994 2996 W4226026819.pdf 2 13 text 0.9992567 "The above literature suggests that arthroscopic-assisted co re decompression is a promising and efficacious treatment option inthetreatmentofpre-collapsestagesofONFHwithorwithout additional intra-articular pathology. However, based on th e paucity of literature and identification of only one randomiz ed trial, there is currently only weak evidence to support its use and additional, high-quality trials are needed. In this cur rent review, only one study had reported patient reported outcomes, the HHS at a mean 30-month follow-up. Future studies should incorporate patient reported outcomes at regular postoperative follow-up to determine subjective patient experience followi ng arthroscopic-assistedcoredecompression." 2996 3739 W4226026819.pdf 2 14 separator 0.99304247 ¶ 3739 3741 W4226026819.pdf 2 15 title 0.98992676 CONCLUSION 3741 3752 W4226026819.pdf 2 16 separator 0.9964608 ¶ 3752 3754 W4226026819.pdf 2 17 text 0.9995028 "Arthroscopic-assistedcoredecompressionforOFNHhassever al purportedbenefitsincludingtheabilitytovisualthejointsu rface toavoidpenetration,performdiagnosticarthroscopyandaddre ss concomitantintra-articularpathology,andthepotentialfo rmore comprehensive and accurate debridement of the avascular bon e lesions. Based on the available literature, this procedure m ay effectivelyreducepainandincreasesurvivorshipofthenative hip in patients with pre-collapse ONFH prior, with better outcomes in earlier pre-collapse stages. There is inadequate evidence to recommend the use of biologic adjuncts such as platelet-rich plasma in conjunction with these procedures. Future research is imperative to continue to understand the indications and outcomesofarthroscopic-assistedcoredecompression." 3754 4558 W4226026819.pdf 2 18 separator 0.9953762 ¶ 4558 4560 W4226026819.pdf 2 19 title 0.981421 AUTHOR CONTRIBUTIONS 4560 4581 W4226026819.pdf 2 20 separator 0.9944582 ¶ 4581 4583 W4226026819.pdf 2 21 text 0.9926609 "SS was the main author of this mini-review, performing the literature search and drafting/revising of this article. K K played a significant role in the revisions and writing of this manusc ript as well as literature search for the final product. BN formulat ed anddesignedtheoutlineofthismini-reviewandprovidedcru cial editing and supervision to the final manuscript. All authors contributedtothearticleandapprovedthesubmittedversion ." 4583 5029 W4226026819.pdf 2 22 separator 0.9955095 ¶ 5029 5031 W4226026819.pdf 2 23 title 0.9252245 REFERENCES 5031 5042 W4226026819.pdf 2 24 separator 0.9932872 ¶ 5042 5044 W4226026819.pdf 2 25 bibliography 0.9977022 "1. Guerado E, Caso E. The physiopathology of avascular necrosis of the femoral head: an update. Injury. (2016) 47(Suppl. 6):S16–26.doi:10.1016/S0020-1383(16)30835-X" 5044 5213 W4226026819.pdf 2 26 separator 0.949732 ¶ 5213 5215 W4226026819.pdf 2 27 bibliography 0.99788725 "2. GlimcherMJ,KenzoraJE.NicolasAndryaward.Thebiologyofosteo necrosis ofthehumanfemoralheadanditsclinicalimplications:1.Tissuebi ology.Clin Orthop.(1979)284–309." 5215 5380 W4226026819.pdf 2 28 separator 0.9514469 ¶ 5380 5382 W4226026819.pdf 2 29 bibliography 0.99760085 "3. Glimcher MJ, Kenzora JE. The biology of osteonecrosis of the huma n femoral head and its clinical implications: II. The pathological cha nges in the femoral head as an organ and in the hip joint. Clin Orthop. (1979) 139:283−312.doi:10.1097/00003086-197903000-000404. BaigSA,BaigMN.Osteonecrosisofthefemoralhead:etiology, investigations, andmanagement. Cureus.(2018)10:e3171.doi:10.7759/cureus.3171" 5382 5791 W4226026819.pdf 2 30 separator 0.98417664 ¶ 5791 5793 W4226026819.pdf 2 31 bibliography 0.9978974 "5. Mont MA, Cherian JJ, Sierra RJ, Jones LC, Lieberman JR. Nontraumat ic osteonecrosis of the femoral head: where do we stand today? A ten- year update.JBoneJointSurgAm. (2015)97:1604–27.doi:10.2106/JBJS.O.00071" 5793 6009 W4226026819.pdf 2 32 separator 0.9718536 ¶ 6009 6011 W4226026819.pdf 2 33 bibliography 0.9978663 "6. Shah KN, Racine J, Jones LC, Aaron RK. Pathophysiology and risk factors for osteonecrosis. Curr Rev Musculoskelet Med. (2015) 8:201–9. doi: 10.1007/s12178-015- 9277-8" 6011 6187 W4226026819.pdf 2 34 separator 0.96243626 ¶ 6187 6189 W4226026819.pdf 2 35 bibliography 0.9978284 "7. Moya-Angeler J, Gianakos AL, Villa JC, Ni A, Lane JM. Current con cepts on osteonecrosis of the femoral head. World J Orthop. (2015) 6:590– 601.doi:10.5312/wjo.v6.i8.590" 6189 6366 W4226026819.pdf 2 36 separator 0.96098197 ¶ 6366 6368 W4226026819.pdf 2 37 paratext 0.98427415 Frontiers in Surgery | www.frontiersin.org 3 April 2022 | Volume 9 | Article 662722 6368 6452 W4226026819.pdf 2 0 title 0.9855189 Table 1 Macrohaemodynamics 0 26 W2143126467.pdf 6 1 separator 0.988385 ¶ 26 28 W2143126467.pdf 6 2 table 0.9931403 "HRa [beats/min]MAPa [mmHg]BRa [breaths/min]HRb [beats/min]MAPb [mmHg]BRb [breaths/min]CIb [ml/min/kg]SVIb [ml/beat/min]TPRIb [mmHg/ml/min/kg]DO 2-Ib [ml/min/kg] Control 382 ± 25§ 115 ± 11 78 ± 12 378 ± 35 92 ± 9 99 ± 12 379 ± 55 1.11 ± 0.19 0.31 ± 0.15 70.4 ± 15.6 Sham 428 ± 22 120 ± 7 72 ± 10 383 ± 48 98 ± 17 92 ± 14 447 ± 112 1.24 ± 0.25 0.28 ± 0.11 76.5 ± 18.8sCASP 388 ± 22§ 128 ± 6 64 ± 10 446 ± 56*§ 80 ± 11§ 107 ± 23 453 ± 72 1.00 ± 0.20 0.26 ± 0.04 81.7 ± 16.3" 28 523 W2143126467.pdf 6 3 separator 0.96968687 ¶ 523 525 W2143126467.pdf 6 4 table 0.49646282 aBaseline measurements ( 525 550 W2143126467.pdf 6 5 text 0.36541897 see Figure 550 560 W2143126467.pdf 6 6 table 0.4776503 1);bintra-OP measurements ( 560 588 W2143126467.pdf 6 7 text 0.35142994 see Figure 588 598 W2143126467.pdf 6 8 table 0.6577843 "1). HR, heart rate; MAP, mean arterial pressure; BR, breathing rate; CI, cardiac index; SVI, stroke volume index; TPRI, total peripheral resistance index; DO 2-I, oxygen delivery index, * p< 0.05 vs. control, § p<0.05 vs. sham." 598 828 W2143126467.pdf 6 9 paratext 0.6987333 Schick 828 834 W2143126467.pdf 6 10 bibliography 0.43561086 et 834 837 W2143126467.pdf 6 11 paratext 0.90840983 al. Intensive Care Medicine Experimental 2014, 2:34 Page 7 of 17 837 902 W2143126467.pdf 6 12 separator 0.8892851 ¶ 902 904 W2143126467.pdf 6 13 paratext 0.9570315 http://www.icm-experimental.com/content/2/1/34 904 951 W2143126467.pdf 6 0 paratext 0.918763 "DIDASCEIN : Journal of English Education September 2022, Vol. 3 No.2 ¶ 75" 0 81 W4320063919.pdf 1 1 separator 0.9723288 ¶ 82 84 W4320063919.pdf 1 2 title 0.9922657 INTRODUCTION 85 98 W4320063919.pdf 1 3 separator 0.9944389 ¶ 100 102 W4320063919.pdf 1 4 text 0.99942774 "ne of the most efficient ways to express our feelings, thoughts, ideas, and opinions to someone or to others is through language. In order to communicate with others, it is crucial for humans to be able to speak any language." 102 334 W4320063919.pdf 1 5 separator 0.7438162 ¶ 335 337 W4320063919.pdf 1 6 text 0.99968207 "Hadley (2001) defined language as the thoughts and emotions that are communicated to other people through engagement or conversation. The importance of learning English today cannot be overstated because it is a major international language. Engl ish is not only used and spoken by native speakers; persons who reside in nations where English is recognized as a second language, or a foreign language also use it. English is taught as a required subject in elementary schools, junior high schools, senio r high schools, and universities in Indonesia and is regarded as a foreign language." 337 944 W4320063919.pdf 1 7 separator 0.977735 ¶ 946 948 W4320063919.pdf 1 8 text 0.99962443 "The four fundamental abilities in English are writing, speaking, reading, and listening. The two categories of productive skills and receptive skills each include four fundamental talents. Reading and listening are regarded as receptive skills, but speakin g and writing are considered productive. One of the four fundamental abilities is writing." 948 1305 W4320063919.pdf 1 9 separator 0.95488137 ¶ 1306 1308 W4320063919.pdf 1 10 text 0.999724 "Writing refers to skill used to express ideas, thoughts, and feelings to other people in written form (Setiani, 2021). When the pupils start interacting with others at the school level, they start learning English through written form for communication. Students find writing to be more challenging than other language abilities. Writing is the ability to utilize written language to communicate with others, according to the National Evaluation of Educational Progress (2011), making the need for effective writing education and assessment more important than ever (p.1). One of the fundamental English abilities is writing. For students of foreign languages, writing is typic ally regarded as one of the most challenging talents. Even native speakers struggle to write well, according to Johnstone, Ashbaugh, and Warfield (2002)." 1308 2169 W4320063919.pdf 1 11 separator 0.9722985 ¶ 2171 2173 W4320063919.pdf 1 12 text 0.9997004 "In addition, Kelog g (2008) notes that writing aids in the development of vocabulary, the reinforcemen t of grammatical structure, and the development of other language abilities including reading, listening, and speaking. Multiple texts were taught to vocational high school students as part of the K13 curriculum as they learned and practiced writing. They were procedural, narrative, recount, report, and descriptive." 2173 2607 W4320063919.pdf 1 13 separator 0.98071873 ¶ 2608 2610 W4320063919.pdf 1 14 text 0.9996974 "According to the curriculum, teachers should also teach students how to write straightforward transactional and interpersonal texts that include expressions like asking for and offering complime nts, expressing an opinion, issuing an invitation, and making an announcement. The research's typing skills were concentrated on writing, particularly composing descriptive prose. According to Wardiman, Jahur, and Djusman (2008), descriptive text is any te xt that describes the characteristics of someone, something, or a specific location (p.16). This method could be used to teach students how to write descriptive texts. Descriptive text, on the other hand, is text that talks about a specific person, thing, or place. To write a descriptive text, we must use our imagination and visualization because we must describe specific people, things, or places in specific ways." 2610 3509 W4320063919.pdf 1 15 separator 0.8884518 ¶ 3510 3512 W4320063919.pdf 1 16 text 0.999462 Running dictation could thus be used to assist students in creating descriptive text. 3512 3598 W4320063919.pdf 1 17 separator 0.9552939 ¶ 3600 3602 W4320063919.pdf 1 18 text 0.9995869 "Running dictation, according to Duncan and Westgate (2010), is an activity that generates a lot of excitement and encourages participation from all classes, with individual students filling a variety of roles. Running Dictation is a dictation activity that O" 3602 3868 W4320063919.pdf 1 0 paratext 0.9276571 Martins et al. : Geochemical data used for climatic reconstruction during the Holocene 0 87 W1482989464.pdf 4 1 separator 0.9288893 ¶ 87 89 W1482989464.pdf 4 2 paratext 0.72658646 297 89 93 W1482989464.pdf 4 3 title 0.7427625 The values of the Kubler index of illite crystallinity 93 147 W1482989464.pdf 4 4 paratext 0.3365727 147 148 W1482989464.pdf 4 5 separator 0.48707667 ¶ 148 149 W1482989464.pdf 4 6 paratext 0.42212382 (Kubler, 1964; Segonzac, 1969 149 179 W1482989464.pdf 4 7 title 0.47811756 ) and the kaolinite/illite ratio arehigher in two particular sections of the core, between 179 269 W1482989464.pdf 4 8 paratext 0.25812528 164 269 273 W1482989464.pdf 4 9 title 0.3426884 and 273 277 W1482989464.pdf 4 10 paratext 0.2699342 120 277 280 W1482989464.pdf 4 11 title 0.32751325 cm, and 280 289 W1482989464.pdf 4 12 bibliography 0.36235872 "between 85 and 45 cm, and show a tendency to increase between 20 and 0 cm (fig. 3)." 289 374 W1482989464.pdf 4 13 separator 0.990922 ¶ 374 376 W1482989464.pdf 4 14 text 0.9995988 "In the 164–115 cm section, higher contents of kaolinite and smectite occur. In the 115–95 cm section, the abundance ofthese clay minerals decreases, bu t illite and chlorite contents increase. In the 90–50 cm sec tion, smectite content increases and kaolinite content shows the highest values despite thereduction of kaolinite content starting at 85 cm (fig. 3). In thesediments of the upper 50 cm of the core, chlorite persists inhigher contents whereas smect ite is absent or rare. Between 18 and 30 cm, the kaolinite/illite ratio decreases notably(fig. 3)." 376 944 W1482989464.pdf 4 15 separator 0.9687898 ¶ 944 946 W1482989464.pdf 4 16 text 0.997846 "Pyrite is always present alon g the core, both in the sand fractions as framboidal sed imentary deposits and in pyritized shells of benthic foraminifera." 946 1104 W1482989464.pdf 4 17 separator 0.9743685 ¶ 1104 1106 W1482989464.pdf 4 18 text 0.63180625 Ben 1106 1110 W1482989464.pdf 4 19 title 0.5079396 thic foramini 1110 1123 W1482989464.pdf 4 20 text 0.9433832 "fera assemblages along core KSGX 40 consist of autochthonous individuals (not showing transportmarks) and of transported shells (broken or abraded)." 1123 1273 W1482989464.pdf 4 21 separator 0.5890795 ¶ 1273 1275 W1482989464.pdf 4 22 text 0.9981219 "The total number of foraminifera (benthic and planktonic) shells per gram of sediment is, as a rule, higher below the depthof 80 cm down to the basis of the core (<6500 shells per gramof sediment), this section also being characterized by a higher number of autochthonous benthic foraminifera and transportedshells (fig. 4)." 1275 1605 W1482989464.pdf 4 23 separator 0.9605645 ¶ 1605 1607 W1482989464.pdf 4 24 text 0.9688759 "Some species of the benthi c foraminifera assemblages found in core KSGX 40 are better represented in the inner and/or middle shelf environments of this North Atlantic region." 1607 1785 W1482989464.pdf 4 25 separator 0.7954842 ¶ 1785 1787 W1482989464.pdf 4 26 text 0.999006 "Such is the case of Ammonia beccarii , Asterigerinata mamila ,La abundancia relativa de partículas granulares no cohesi- vas muestra valores > 65% en la sección de 33 a 55 cm y debajo de 76 cm (fig. 2). El contenido de CaCO 3 varía de 2% a 18% del peso de sedimento seco y es mayor en la sección infe- rior del sondeo (fig. 2). Las conchas de foraminíferos y moluscos son importantes componentes biogénicos de estos sedimento y contribuyen significativamente al CaCO3 total." 1787 2276 W1482989464.pdf 4 27 separator 0.9706372 ¶ 2276 2278 W1482989464.pdf 4 28 text 0.9992589 "La ilita (50–75%) es el mineral arcilloso predominante, seguida por la caolinita (16–18% ), la esmectita (0–15%) y la clorita (2–10%). La ilita y la caolinita, así como la clorita y la esmectita, varían de forma opues ta en el sondeo estudiado (fig. 3)." 2278 2540 W1482989464.pdf 4 29 separator 0.9410728 ¶ 2540 2542 W1482989464.pdf 4 30 text 0.9984239 "Los valores del índice de Kubler de cristalinidad de la ilita (Kubler, 1964; Segonzac, 1969) y la razón caolinita/ilita son mayores en dos secciones partic ulares del sondeo, entre 164 y 120 cm y entre 85 y 45 cm, y mu estran una tendencia a incre- mentar entre 20 y 0 cm (fig. 3)." 2542 2832 W1482989464.pdf 4 31 separator 0.9553728 ¶ 2832 2834 W1482989464.pdf 4 32 text 0.99951375 "En la sección de 164 a 115 cm se encuentran contenidos mayores de caolinita y esmectita. En la sección de 115 a 95 cm, decrece la abundancia de esto s minerales arcillosos, pero aumentan los contenidos de ilita y clorita. En la sección de 90 a 50 cm el contenido de esmectita se incrementa y el contenido de caolinita muestra sus valores más altos a pesar de que el contenido de este mineral se empieza a reducir a los 85 cm (fig. 3). En los sedimentos de los 50 cm superiores del sondeo persisten los elevados conteni dos de clorita mientras que la esmectita es escasa o está ausente. Entre los 18 y 30 cm la razón caolinita/ili ta decrece notablemente (fig. 3)." 2834 3520 W1482989464.pdf 4 33 separator 0.9782764 ¶ 3520 3522 W1482989464.pdf 4 34 text 0.99794084 "La pirita siempre está presente a lo largo del sondeo, tanto en las fracción de area en la fo rma de depósitos sedimentarios framboidales como en conchas piritizadas de foraminíferos bentónicos." 3522 3724 W1482989464.pdf 4 35 separator 0.9713249 ¶ 3724 3726 W1482989464.pdf 4 36 text 0.99538314 "Las asociaciones de foraminífe ros bentónicos en el sondeo KSGX 40 están formadas por individuos autóctonos (sin señales de transporte) y por conchas transportadas (rotas o gastadas)." 3726 3916 W1482989464.pdf 4 37 separator 0.85409737 ¶ 3916 3918 W1482989464.pdf 4 38 text 0.9985353 "El número total de conchas de foraminíferos (bentónicos y planctónicos) por gramo de sedimento es, en general, mayor por debajo de la profundidad de 80 cm hasta la base del sondeo (<6500 conchas por gramo de sedimento), caracterizándose esta sección por un mayor númer o de foraminíferos bentónicos autóctonos y de conchas transportadas (fig. 4)." 3918 4275 W1482989464.pdf 4 39 separator 0.97655237 ¶ 4275 4277 W1482989464.pdf 4 40 text 0.8854289 "Algunas especies de las asociaciones de foraminíferos bentónicos están mejor representadas en los ambientes de la plataforma interna y/o media de esta región del Atlántico Norte. Tal es el caso de Ammonia beccarii , Asterigerinata mamila , Bolivina pseudoplicata, Cibicides ungerianus , Cribrononion gerthi , Discorbis mira , D. williamsoni , Eggerelloides scaber , Elphidium complanatum , E. crispum, E. discoidale , E. macellum var. aculeatum , E. pulvereum , Haynesina depressula , Lepidodeuterammina ochracea , Planorbulina mediterranensis , Quinqueloculina seminulum y Remaneica helgolandica (Pujos, 1976" 4277 4911 W1482989464.pdf 4 41 bibliography 0.48301542 ; 4911 4912 W1482989464.pdf 4 42 text 0.5001803 Blanc- 4912 4919 W1482989464.pdf 4 43 bibliography 0.5192203 Vernet et al. 4919 4932 W1482989464.pdf 4 44 separator 0.36867827 4932 4933 W1482989464.pdf 4 45 table 0.29599616 , 4933 4934 W1482989464.pdf 4 46 caption 0.9947818 "Figure 3. Vertical evolution of the clay mineral content, kaolinite/illite ratio and Kubler index of illite crystallinity. Sediment layers dated by 14C are marked." 4934 5102 W1482989464.pdf 4 47 separator 0.9733553 ¶ 5102 5104 W1482989464.pdf 4 48 caption 0.9966442 "Figura 3. Evolución vertical del contenido de mineral arcilloso, de la razón caolinita/ilita y del índice de Kubler de cristalinidad de la ilita. Se indican las capas de sedimento fechadas mediante 14C." 5104 5312 W1482989464.pdf 4 0 title 0.953546 Utsunomiya et al. Selection in the bovine genome 0 48 W2021698582.pdf 4 1 separator 0.7210367 ¶ 48 50 W2021698582.pdf 4 2 text 0.9993149 "function of physical distance can be assessed to determine the extension of the haplotype homozygosity. From this seminalconcept, a family of statistical methods was developed in orderto scan entire genomes in the search for evidence of selection." 50 300 W2021698582.pdf 4 3 separator 0.91851985 ¶ 300 302 W2021698582.pdf 4 4 text 0.99702454 "Voight et al. (2006) proposed to measure how rapidly EHH decays from a core SNP site by calculating the area under the EHH curve," 302 436 W2021698582.pdf 4 5 separator 0.84635663 ¶ 436 438 W2021698582.pdf 4 6 text 0.6049525 iHH 438 442 W2021698582.pdf 4 7 math 0.53029084 =/ 442 444 W2021698582.pdf 4 8 text 0.6515776 integraldisplay 444 459 W2021698582.pdf 4 9 math 0.67111915 "¶ b aEHH (x)dx" 459 476 W2021698582.pdf 4 10 text 0.9819827 "¶ where iHH represents the definite integral of EHH evaluated over the domain of the chromosome segment delimited by upstreamposition aand downstream position bwhere EHH decays to some arbitrary small value (originally 0.05). As the area under the curveis not tractable analytically, a trapezoid quadrature with non-uniform grid can be adopted as a deterministic approximation:" 476 857 W2021698582.pdf 4 11 separator 0.94633037 ¶ 857 859 W2021698582.pdf 4 12 math 0.9401424 "iHH∼ K/summationdisplay k=1(xk+1−xk)(EHH k+1+EHH k) 2" 859 919 W2021698582.pdf 4 13 separator 0.9843654 ¶ 919 921 W2021698582.pdf 4 14 text 0.9665382 "A within population score, namely Integrated Haplotype Score (iHS), for a given site i,w a si n t r o d u c e db y Voight et al. (2006) " 921 1060 W2021698582.pdf 4 15 separator 0.55798453 ¶ 1060 1061 W2021698582.pdf 4 16 text 0.98447454 "as the log-ratio between the integrated EHH for the haplotypes containing the ancestral allele ( iHH A) and the derived allele (iHH D):" 1061 1201 W2021698582.pdf 4 17 separator 0.8952967 ¶ 1201 1203 W2021698582.pdf 4 18 math 0.9002807 "iHS i=ln/parenleftbiggiHH A,i iHH D,i/parenrightbigg" 1203 1258 W2021698582.pdf 4 19 text 0.8959346 "¶ These scores are then standardized to have mean zero and vari- ance one." 1258 1335 W2021698582.pdf 4 20 separator 0.98176414 ¶ 1335 1337 W2021698582.pdf 4 21 text 0.9995858 "Extremely negative standardized iHSvalues have been of par- ticular interest in human genetics, as they represent a recentlyacquired mutation that increased very rapidly in frequency (i.e.,there is a partial sweep due to ongoing selection) or a haplo-type that hitchhiked to fixation and then became enriched forderived alleles ( Voight et al., 2006 ). However, a sweep can also produce large positive iHSvalues at nearby SNPs if ancestral alle- les hitchhike with the selected site, so the chromosome regionsurrounding the selected variant typically exhibits a cluster ofextreme positive and negative iHS v a l u e s .F u r t h e r m o r e ,i nt h e context of cattle data, artificial selection and domestication prob-ably favored “beneficial” alleles in the sense of human interest,regardless if it is ancestral or derived. Therefore, both positive andnegative values should be investigated in cattle data. This impli-cates that the absolute value of standardized iHSscores should be preferred over the signed values, or, equivalently, that a two tailedhypothesis test should be assumed. As only partial ancestral alleleinformation is available for cattle SNP assays, and the search forfootprints of selection by iHSin cattle should disregard the direc- tion of the sweep, a more appropriate generalized version of iHS can be postulated as the log-ratio between the integrated EHH for an arbitrary reference allele ( iHH REF) and for the alternative allele (iHH ALT)." 1337 2824 W2021698582.pdf 4 22 separator 0.9645486 ¶ 2824 2826 W2021698582.pdf 4 23 text 0.99950135 "One of the limitations of this method is that if a given marker presents a nearly or completely fixed allele in the populationbeing analyzed, this allele will have no integral to be calculated or an integral close to zero, so the log-ratio will result in a pos-itive or negative infinite value. In this scenario, the calculationofiHS must be conditioned by iHH REF>0a n d iHH ALT>0, which indirectly leads to a minor allele frequency (MAF) con-straint. This limitation renders iHSunderpowered to detect very recent nearly fixed selective sweeps, which are of primary interestin the cattle community. However, as discussed earlier, a crucialpoint to be considered is that contiguous chromosomal segmentscontaining SNPs with MAF =0 can also result from SNP chip ascertainment bias, which may produce false positive signals." 2826 3657 W2021698582.pdf 4 24 separator 0.98698914 ¶ 3657 3659 W2021698582.pdf 4 25 text 0.9995287 "Tang et al. (2007) andSabeti et al. (2007) have independently developed equivalent methods, Rsb and XPEHH ,r e s p e c t i v e l y , which attempt to compare long-range haplotypes between popu-lations in order to increase the power of selective sweep detection.The most crucial improvement is that, for each population beinganalyzed iHH is calculated for the entire sample, instead of being partitioned between derived and ancestral alleles. This eliminatesthe MAF constraint and recovers the power to detect sweepsreaching fixation. The comparison with a population where theselective sweep may not have occurred adds extra power to themethod. Calculations are performed as follows:" 3659 4348 W2021698582.pdf 4 26 separator 0.98998404 ¶ 4348 4350 W2021698582.pdf 4 27 math 0.8593909 "XPEHH i=Rsb i=ln/parenleftbiggiHH pop1,i iHH pop2,i/parenrightbigg" 4350 4421 W2021698582.pdf 4 28 separator 0.94873405 ¶ 4421 4423 W2021698582.pdf 4 29 text 0.99956405 "Where, relative to SNP i,iHH pop1,iis the integrated EHH in the first population and iHH pop2,iis the integrated EHH in the second population. Scores are also standardized to produce a distributionof standard deviates. Positive values indicate selective sweeps inthe population used in the numerator, while negative values indi-cate selection in the population used in the denominator. Here, itis easy to keep track of the signals by using one-tailed hypothesistests." 4423 4894 W2021698582.pdf 4 30 separator 0.9908267 ¶ 4894 4896 W2021698582.pdf 4 31 text 0.9969249 "Studies applying EHH -based methods to cattle data are numerous (for instance, Hayes et al., 2008; Gautier and Naves, 2011; Qanbari et al., 2011, 2014; Flori et al., 2012; Utsunomiyaet al., 2013; Huson et al., 2014 ). The reported loci are deemed to be genome responses to a variety of different selective pres-sures, such as milk and meat production, coat color, heat stress,and reproductive performance. Among these, one particularlyinteresting selective sweep, most likely related to adaptation toheat stress, has been reported in Creole cattle, including Senepol,Carora, Romosinuano, and cross-bred lineages ( Flori et al., 2012; Huson et al., 2014 ). These cattle breeds present the slick hair coat phenotype, a dominant trait associated to heat tolerance intropically adapted cattle that descend from Spanish cattle intro-duced to the New World. The chromosome segment containingthe selective sweep ranges from 37.5 to 39.6 Mb on chromosome20, with a variable peaking position (39.5 or 37.7 Mb) depend-ing on the SNP panel (BovineSNP50 or BovineHD) and datasetanalyzed ( Flori et al., 2012; Huson et al., 2014 ). The disputed posi- tional candidate genes are the retinoic acid induced 14 ( RAI14 orNORPEG ), prolactin receptor ( PRLR ), and S-phase kinase- associated protein 2 ( SKP2 ). A strong candidate mutation has been recently proposed for PRLR ,as i n g l eb a s ed e l e t i o ni ne x o n 10 (ss1067289408) predicted to cause a frameshift that introduces ¶" 4896 6388 W2021698582.pdf 4 32 paratext 0.976822 www.frontiersin.org February 2015 | Volume 6 | Article 36 |5 6388 6449 W2021698582.pdf 4 0 paratext 0.9867683 Eng. & Tech. Journal, Vol.27, No. 11, 2009 0 42 W2186937257.pdf 3 1 title 0.91713536 "Analysis and design of PID Control System for Active Magnetic Bearings" 82 264 W2186937257.pdf 3 2 separator 0.88921887 "¶ ¶" 266 300 W2186937257.pdf 3 3 math 0.8088958 300 301 W2186937257.pdf 3 4 paratext 0.39331564 2308 301 305 W2186937257.pdf 3 5 math 0.9173191 "snix2 n pkkk mwk+= ¶ snin dkkmw2Tx=" 306 356 W2186937257.pdf 3 6 separator 0.8312633 ¶ ¶ 360 368 W2186937257.pdf 3 7 title 0.9931405 "5. Design of PID Controller using the Two Degrees of Freedom Approach" 368 441 W2186937257.pdf 3 8 separator 0.99256146 ¶ 444 446 W2186937257.pdf 3 9 text 0.99900675 "When the system is subjected to disturbances and noises it is useful to use a modified PID control schemes instead of the basic PID control. One of those control schemes is the two-degree-of-freedom control scheme [1]. In this scheme, we have a controller in the feed forward path and another controller in the feedback path." 450 797 W2186937257.pdf 3 10 separator 0.9854716 ¶ 798 800 W2186937257.pdf 3 11 math 0.9448528 Gc=G c1+G c2 800 813 W2186937257.pdf 3 12 separator 0.97427773 ¶ 814 816 W2186937257.pdf 3 13 text 0.99671143 "The PID controller designed using the two-degrees-of-freedom configuration satisfy two independent requirements, such as the response characteristics to disturbance input and these to reference input. Figure 4 shows a two-degree-of- freedom control system." 820 1094 W2186937257.pdf 3 14 separator 0.7871731 ¶ 1234 1236 W2186937257.pdf 3 15 text 0.9937101 "The controller will be designed to satisfy the following requirements: a- The response to the step disturbance input is damp out quickly. b- The maximum overshoot in the response to the unit-step reference input be less than 20% but more than 2%, and the settling time be less than 0.05 second. c- The steady-state errors in the responses to both the ramp and acceleration reference inputs should be zero." 1240 1681 W2186937257.pdf 3 16 separator 0.89487845 ¶ 1682 1684 W2186937257.pdf 3 17 text 0.9901487 "To design suitable controllers Gc1 and Gc2, the design procedure will be performed in two main steps: Design step (1): In this step assumption is made where the reference input is zero." 1688 1890 W2186937257.pdf 3 18 separator 0.7018016 ¶ 1891 1893 W2186937257.pdf 3 19 text 0.9502552 "The transfer function from disturbing force Fd(s) to displacement output X(s) is given by:" 1893 1990 W2186937257.pdf 3 20 separator 0.70613873 ¶ 1991 1993 W2186937257.pdf 3 21 math 0.8960813 "c snipp d GkkG1G )s(F)s(X += (7) ¶" 1993 2037 W2186937257.pdf 3 22 text 0.6149702 Where, ¶ 2037 2047 W2186937257.pdf 3 23 math 0.6643017 x2 pk ms1)s(G 2047 2061 W2186937257.pdf 3 24 text 0.54197335 ¶ 2061 2063 W2186937257.pdf 3 25 math 0.6450479 −= Gc 2063 2070 W2186937257.pdf 3 26 text 0.76594037 is defined as a PID controller such that ¶ 2070 2114 W2186937257.pdf 3 27 math 0.5577688 [1] 2114 2118 W2186937257.pdf 3 28 text 0.50400835 : 2118 2119 W2186937257.pdf 3 29 math 0.9270086 ¶ s) s)( s(kGcb a+ += (8) 2121 2175 W2186937257.pdf 3 30 separator 0.46247143 ¶ 2224 2226 W2186937257.pdf 3 31 math 0.52299833 Substituting 2226 2239 W2186937257.pdf 3 32 text 0.4892683 for 2239 2243 W2186937257.pdf 3 33 math 0.8850387 "Gc and Gp in equation (7) and rearranging: =)s(F)s(X d ab ba ksnkiks]xk) (ksnkik[2kssnkik3mss + −+ + + (9)" 2243 2435 W2186937257.pdf 3 34 separator 0.9507512 ¶ 2499 2501 W2186937257.pdf 3 35 text 0.99564314 "To satisfy the requirement that the steady-state errors in the responses to both the ramp and acceleration reference inputs be zero, we refer to the zero-placement method [1] and choose the closed-loop transfer function X(s)/X o(s) to be of the following form:" 2505 2784 W2186937257.pdf 3 36 separator 0.8016308 ¶ 2785 2787 W2186937257.pdf 3 37 math 0.9601931 "=)s(X)s(X o c)b a(s)ac2 b a( s)ca2(sc)b a(s)ac2 b a( s)ca2( 2 2 2 2 2 32 2 2 2 2 ++ +++ ++++ +++ + (10)" 2787 2928 W2186937257.pdf 3 38 separator 0.9241371 ¶ 2929 2931 W2186937257.pdf 3 39 text 0.99824184 "In which case the third requirement is automatically satisfied. In MATLAB a computational approach is used to search optimal set or sets of desired closed-loop poles in terms of a, b, and c in the specified region. Such that the system will satisfy the requirement on the response to the unit-step reference input that the maximum overshoot be between 2% and 20% and the settling time be less than 0.05 second." 2931 3369 W2186937257.pdf 3 40 separator 0.8817789 ¶ 3370 3372 W2186937257.pdf 3 41 text 0.90708154 "MATLAB program produces a table of sets of acceptable values of a, b, and c." 3372 3452 W2186937257.pdf 3 42 separator 0.96290433 ¶ 3453 3455 W2186937257.pdf 3 43 text 0.9769753 "For an under damped system the dominant closed-loop poles are complex conjugates and may be given by: jba s±−= And the remaining closed-loop pole is real and is located at: s = – c" 3459 3684 W2186937257.pdf 3 44 separator 0.8246267 ¶ 3685 3687 W2186937257.pdf 3 45 text 0.99300915 "Consider the same radial magnetic bearing data given in section 4 [4]:" 3691 3765 W2186937257.pdf 3 46 separator 0.696697 ¶ 3766 3768 W2186937257.pdf 3 47 text 0.8394083 "Two sets of closed-loop poles are considered as follows: 1- In the first set the complex conjugate closed loop poles found using root locus" 3772 3925 W2186937257.pdf 3 48 separator 0.9701429 ¶ 3926 3928 W2186937257.pdf 3 49 paratext 0.93796515 PDF created with pdfFactory Pro trial version www.pdffactory.com 3928 3993 W2186937257.pdf 3 0 paratext 0.98729616 F. Alhusain et al. / Journal of Epidemiology and Global Health 10 (4) 276–279 279 0 82 W2997531548.pdf 3 1 separator 0.9936904 ¶ 82 84 W2997531548.pdf 3 2 text 0.9904683 "the SSC bundle elements or the mortality rate. The only significant difference found was the time to the lactate measurement. These find - ings reflect the lack of sepsis awareness of prehospital care providers and management protocols may be a potential area for improvement." 84 369 W2997531548.pdf 3 3 separator 0.995358 ¶ 369 371 W2997531548.pdf 3 4 title 0.96968573 CONFLICTS OF INTEREST 371 393 W2997531548.pdf 3 5 separator 0.9836602 ¶ 393 395 W2997531548.pdf 3 6 text 0.93955797 The authors declare they have no conflicts of interest. 395 451 W2997531548.pdf 3 7 separator 0.9934714 ¶ 451 453 W2997531548.pdf 3 8 title 0.97594535 AUTHORS’ CONTRIBUTION 453 475 W2997531548.pdf 3 9 separator 0.98980916 ¶ 475 477 W2997531548.pdf 3 10 text 0.9806694 "NA, YA and Sami A, designed the study and reviewed the manu - script. NA supervised the study. HA, AA, AB and Sarah A, collected data and wrote the manuscript. FA analyzed and interpreted data, wrote and edited the manuscript." 477 712 W2997531548.pdf 3 11 separator 0.99518263 ¶ 712 714 W2997531548.pdf 3 12 title 0.97045517 ETHICAL APPROVAL 714 731 W2997531548.pdf 3 13 separator 0.9859229 ¶ 731 733 W2997531548.pdf 3 14 text 0.95135593 "The Institutional Review Board, King Abdullah International Medical Research Centre, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia approved this study." 733 909 W2997531548.pdf 3 15 separator 0.9951495 ¶ 909 911 W2997531548.pdf 3 16 title 0.90498424 REFERENCES 911 922 W2997531548.pdf 3 17 separator 0.9896273 ¶ 922 924 W2997531548.pdf 3 18 bibliography 0.99721634 "[1] Napolitano LM. Sepsis 2018: definitions and guideline changes. Surg Infect (Larchmt) 2018;19;117–25." 924 1032 W2997531548.pdf 3 19 separator 0.83426034 ¶ 1032 1034 W2997531548.pdf 3 20 bibliography 0.9979728 "[2] Levy MM, Artigas A, Phillips GS, Rhodes A, Beale R, Osborn T, et al. Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 2012;12;919–24." 1034 1267 W2997531548.pdf 3 21 separator 0.8507277 ¶ 1267 1269 W2997531548.pdf 3 22 bibliography 0.99802005 "[3] Dellinger RP , Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013;41;580–637." 1269 1492 W2997531548.pdf 3 23 separator 0.7898501 ¶ 1492 1494 W2997531548.pdf 3 24 bibliography 0.9976602 "[4] Stevenson EK, Rubenstein AR, Radin GT, Wiener RS, Walkey AJ. Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis. Crit Care Med 2014;42;625–31." 1494 1691 W2997531548.pdf 3 25 separator 0.8384867 ¶ 1691 1693 W2997531548.pdf 3 26 bibliography 0.9972909 "[5] Kaukonen KM, Bailey M, Suzuki S, Pilcher D, Bellomo R. Mortality related to severe sepsis and septic shock among crit - ically ill patients in Australia and New Zealand, 2000–2012. JAMA 2014;311;1308–16." 1693 1909 W2997531548.pdf 3 27 separator 0.8223146 ¶ 1909 1911 W2997531548.pdf 3 28 bibliography 0.9979737 "[6] Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective anti - microbial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34;1589–96." 1911 2166 W2997531548.pdf 3 29 separator 0.8385427 ¶ 2166 2168 W2997531548.pdf 3 30 bibliography 0.99806786 "[7] Seymour CW , Gesten F, Prescott HC, Friedrich ME, Iwashyna TJ, Phillips GS, et al. Time to treatment and mortality during man - dated emergency care for sepsis. N Engl J Med 2017;376;2235–44." 2168 2369 W2997531548.pdf 3 31 separator 0.83446157 ¶ 2369 2371 W2997531548.pdf 3 32 bibliography 0.99768454 "[8] Guerra WF, Mayfield TR, Meyers MS, Clouatre AE, Riccio JC. Early detection and treatment of patients with severe sepsis by prehospital personnel. J Emerg Med 2013;44; 1116–25." 2371 2557 W2997531548.pdf 3 33 separator 0.8224308 ¶ 2557 2559 W2997531548.pdf 3 34 bibliography 0.9979091 "[9] Iwami T, Nichol G, Hiraide A, Hayashi Y , Nishiuchi T, Kajino K, et al. Continuous improvements in “chain of survival” increased survival after out-of-hospital cardiac arrests. Circulation 2009;119;728–34." 2559 2775 W2997531548.pdf 3 35 separator 0.8388071 ¶ 2775 2777 W2997531548.pdf 3 36 bibliography 0.9980176 "[10] Minnerup J, Wersching H, Unrath M, Berger K. Effects of emer - gency medical service transport on acute stroke care. Eur J Neurol 2014;21;1344–7.[11] Stiell IG, Nesbitt LP , Pickett W , Munkley D, Spaite DW , Banek J, et al. The OPALS Major Trauma Study: impact of advanced life-support on survival and morbidity. CMAJ 2008;178;1141–52." 2777 3130 W2997531548.pdf 3 37 separator 0.8452654 ¶ 3130 3132 W2997531548.pdf 3 38 bibliography 0.9979529 "[12] Jones J, Lawner BJ. Prehospital sepsis care. Emerg Med Clin North Am 2017;35;175–83." 3132 3225 W2997531548.pdf 3 39 separator 0.7899847 ¶ 3225 3227 W2997531548.pdf 3 40 bibliography 0.99798113 "[13] Lane D, Ichelson RI, Drennan IR, Scales DC. Prehospital manage- ment and identification of sepsis by emergency medical ser vices: a systematic review. Emerg Med J 2016;33;408–13." 3227 3416 W2997531548.pdf 3 41 separator 0.8251946 ¶ 3416 3418 W2997531548.pdf 3 42 bibliography 0.9980038 "[14] Alam N, Oskam E, Stassen PM, van Exter P , van de Ven PM, Haak HR, et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med 2018;6;40–50." 3418 3636 W2997531548.pdf 3 43 separator 0.854061 ¶ 3636 3638 W2997531548.pdf 3 44 bibliography 0.99793714 "[15] Bullard MJ, Musgrave E, Warren D, Unger B, Skeldon T, Grierson R, et al. Revisions to the Canadian Emergency Department Triage and Acuity Scale (CTAS) Guidelines 2016. CJEM 2017;19:S18–S27." 3638 3842 W2997531548.pdf 3 45 separator 0.85875094 ¶ 3842 3844 W2997531548.pdf 3 46 bibliography 0.99787915 "[16] Böttiger BW , Bernhard M, Knapp J, Nagele P . Influence of EMS- physician presence on survival after out-of-hospital cardiopul - monary resuscitation: systematic review and meta-analysis. Crit Care 2016;20;4." 3844 4065 W2997531548.pdf 3 47 separator 0.7829664 ¶ 4065 4067 W2997531548.pdf 3 48 bibliography 0.9979456 "[17] Femling JK, Weiss SJ, Fullerton L, Erik H, Tarby D. 338 EMS sepsis patients are different from walk-in sepsis patients. Ann Emerg Med 2012;60:S120." 4067 4226 W2997531548.pdf 3 49 separator 0.87365186 ¶ 4226 4228 W2997531548.pdf 3 50 bibliography 0.99792826 "[18] Smyth MA, Brace-McDonnell SJ, Perkins GD. Impact of pre - hospital care on outcomes in sepsis: a systematic review. West J Emerg Med 2016;17;427–37." 4228 4387 W2997531548.pdf 3 51 separator 0.87535423 ¶ 4387 4389 W2997531548.pdf 3 52 bibliography 0.99799645 "[19] Seymour CW , Kahn JM, Martin-Gill C, Callaway CW , Y ealy DM, Scales D, et al. Delays from first medical contact to antibiotic administration for sepsis. Crit Care Med 2017;45 ;759–65." 4389 4585 W2997531548.pdf 3 53 separator 0.8846117 ¶ 4585 4587 W2997531548.pdf 3 54 bibliography 0.9978624 "[20] Sterling SA, Miller WR, Pryor J, Puskarich MA, Jones AE. The impact of timing of antibiotics on outcomes in severe sepsis and septic shock: a systematic review and meta-analysis. Crit Care Med 2015;43;1907–15." 4587 4811 W2997531548.pdf 3 55 separator 0.912003 ¶ 4811 4813 W2997531548.pdf 3 56 bibliography 0.99707484 "[21] Band RA, Gaieski DF, Hylton JH, Shofer FS, Goyal M, Meisel ZF. Arriving by emergency medical services improves time to treat - ment endpoints for patients with severe sepsis or septic shock. Acad Emerg Med 2011;18;934–40." 4813 5048 W2997531548.pdf 3 57 separator 0.9209911 ¶ 5048 5050 W2997531548.pdf 3 58 bibliography 0.99785143 "[22] Walchok JG, Pirrallo RG, Furmanek D, Lutz M, Shope C, Giles B, et al. Paramedic-initiated CMS sepsis core measure bundle prior to hospital arrival: a stepwise approach. Prehospital Emerg Care 2017;21;291–300." 5050 5273 W2997531548.pdf 3 59 separator 0.8939882 ¶ 5273 5275 W2997531548.pdf 3 60 bibliography 0.99799347 "[23] Seymour CW , Cooke CR, Heckbert SR, Spertus JA, Callaway CW , Martin-Gill C, et al. Prehospital intravenous access and fluid resuscitation in severe sepsis: an observational cohort study. Crit Care 2014;18;533." 5275 5500 W2997531548.pdf 3 61 separator 0.8913204 ¶ 5500 5502 W2997531548.pdf 3 62 bibliography 0.99788153 "[24] Seymour CW , Rea TD, Kahn JM, Walkey AJ, Y ealy DM, Angus DC. Severe sepsis in pre-hospital emergency care: analysis of incidence, care, and outcome. Am J Respir Crit Care Med 2012;186 ;1264–71." 5502 5711 W2997531548.pdf 3 63 separator 0.91453075 ¶ 5711 5713 W2997531548.pdf 3 64 bibliography 0.99787956 "[25] Seymour CW , Band RA, Cooke CR, Mikkelsen ME, Hylton J, Rea TD, et al. Out-of-hospital characteristics and care of patients with severe sepsis: a cohort study. J Crit Care 2010;25; 553–62." 5713 5918 W2997531548.pdf 3 65 separator 0.8992585 ¶ 5918 5920 W2997531548.pdf 3 66 bibliography 0.9978686 "[26] Seymour CW , Cooke CR, Mikkelsen ME, Hylton J, Rea TD, Goss CH, et al. Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency department. Prehospital Emerg Care 2010;14;145–52." 5920 6143 W2997531548.pdf 3 67 separator 0.8924029 ¶ 6143 6145 W2997531548.pdf 3 68 bibliography 0.9971232 "[27] Sinuff T, Kahnamoui K, Cook DJ, Luce JM, Levy MM; Values Ethics and Rationing in Critical Care Task Force. Rationing critical care beds: a systematic review. Crit Care Med 2004;32; 1588–97." 6145 6350 W2997531548.pdf 3 0 text 0.996102 "salarial que perdurou durante todo o governo de FHC, sobr etudo pelo estímulo às fundaç ões de apoio , que torna vam possív el a comer cialização de cursos e serviços nas univ ersidades , contribuindo assim para a consolidação de um processo gradual de mer cantilização da educação superior (BOSI; REIS, 2008)." 0 319 W1528052797.pdf 6 1 separator 0.99600154 ¶ 319 321 W1528052797.pdf 6 2 title 0.68243265 A política de 321 335 W1528052797.pdf 6 3 text 0.80685616 335 336 W1528052797.pdf 6 4 title 0.70306855 educação superior no Paraná 336 363 W1528052797.pdf 6 5 text 0.98149794 "conduzida pelo governo Jaime Lerner entr e os anos de 1994 a 2002, mostr ava-se em sintonia com as medidas t omadas pelo pr esident e FHC no âmbit o da política nacional . Lerner instituiu medidas de desmont e do ensino superior públic o, orientado pela lógica de enxugament o de “gast os públic os”." 363 676 W1528052797.pdf 6 6 separator 0.94468737 ¶ 676 678 W1528052797.pdf 6 7 text 0.9944858 "As iniciativas reformistas do governo Lerner se deram, desde a concretização da prestação de serviços pelas universidades públicas à sociedade , através da Lei Estadual n. 11.500/96, até a proposta do deputado Eduardo Trevisan que, apoiado pelo governo à época, visava à institucionalização de mensalidades nas univ ersidades mantidas pelo Estado . Tal objetiv o contribuiria para a concr etização de uma terceira medida, a saber : a transf ormação das instituiç ões públicas de ensino superior no Paraná em organizações sociais, conforme previsto no Plano Diretor da Reforma do Apar elho do Estado ." 678 1303 W1528052797.pdf 6 8 separator 0.9450869 ¶ 1303 1305 W1528052797.pdf 6 9 text 0.9985444 "Embora houv esse muitos debates e mobilizações da comunidade acadêmica, cujas ações eram organizadas pelo Comit ê em Defesa do Ensino Superior Públic o do Paraná e pela União Paranaense de Estudant es (REIS, 2001), nenhuma dessas ações coletivas conseguiu inviabilizar que o governo sancionasse tal medida." 1305 1624 W1528052797.pdf 6 10 separator 0.9954407 ¶ 1624 1626 W1528052797.pdf 6 11 text 0.93987155 A Lei n. 11.500/96 previa que: 1626 1657 W1528052797.pdf 6 12 separator 0.9878599 ¶ 1657 1659 W1528052797.pdf 6 13 text 0.7302848 "Art. 1o. A s Instituiç ões de Ensino Superior mantidas pelo Estado do Paraná (IES)," 1659 1746 W1528052797.pdf 6 0 paratext 0.96411884 http://www.revmaterialeplastice.ro MATERIALE PLASTICE ♦55♦No. 4 ♦2018 596that 0 77 W3003562107.pdf 1 1 title 0.4106993 treats 77 84 W3003562107.pdf 1 2 text 0.39407262 plastic 84 92 W3003562107.pdf 1 3 title 0.31942895 as 92 95 W3003562107.pdf 1 4 paratext 0.3899717 95 96 W3003562107.pdf 1 5 text 0.4053395 a insignificant material rather than a 96 134 W3003562107.pdf 1 6 paratext 0.33116978 134 135 W3003562107.pdf 1 7 text 0.5045654 ¶ valuable resource to be 135 160 W3003562107.pdf 1 8 title 0.3038325 exploit 160 168 W3003562107.pdf 1 9 paratext 0.73423004 [23]. 168 174 W3003562107.pdf 1 10 separator 0.9926487 ¶ 174 176 W3003562107.pdf 1 11 text 0.99933934 "Environmental pollution represents an important and complex subject with a huge concern for scientists in different fields, but also for the governments, national and international organizations, because besides theincontestable assets of the industry for the human development, it has negative effects to the human health [3]." 176 515 W3003562107.pdf 1 12 separator 0.91097057 ¶ 515 517 W3003562107.pdf 1 13 text 0.9991257 "For a good understanding of the issues discussed it is necessary to define and explain the processes of biodegradation, composting and oxo-degradation." 517 673 W3003562107.pdf 1 14 separator 0.6663549 ¶ 673 675 W3003562107.pdf 1 15 text 0.992733 "Biodegradation is a process by which material disintegrates and is decomposed by micro-organisms into elements that are found in nature, such as CO2, water and biomass. Biodegradation can occur in an oxygen rich environment (aerobic biodegradation) or in an oxygen poor environment(anaerobic biodegradation). There is currently insufficient evidence to provide assurance that oxo-degradable plastic, including plastic carrier bags, will biodegrade in theenvironment within reasonable time [24]." 675 1184 W3003562107.pdf 1 16 separator 0.7301612 ¶ 1184 1186 W3003562107.pdf 1 17 text 0.99932265 "Recycling waste can be considered the key element of the entire environmental issues, including giving it somesolutions on the conservation of natural resources and energy, and in terms of preserving a healthy and unpolluted habitat in all aspects [18]." 1186 1446 W3003562107.pdf 1 18 separator 0.9963312 ¶ 1446 1448 W3003562107.pdf 1 19 title 0.99225044 Results and discussions 1448 1472 W3003562107.pdf 1 20 separator 0.99470747 ¶ 1472 1474 W3003562107.pdf 1 21 text 0.9995644 "It is too early to draw robust conclusions on the environmental impact that bans and levies have had. In 50 per cent of cases, information about their impact is missing, partly because some countries have adoptedthem only recently and partly because monitoring is deficient." 1474 1757 W3003562107.pdf 1 22 separator 0.69896394 ¶ 1757 1759 W3003562107.pdf 1 23 text 0.9996447 "In countries that do have data, about 30 per cent have registered notable decrease in the consumption of plastic bags within the first year. The remaining 20 per cent ofcountries have reported little to no change.Since the 1950’s, growth in the production of plastic has largely surmounted that of any other material, with a global shift from the production of durable plastics to single-useplastics (including packaging), as shown in figure 1." 1759 2212 W3003562107.pdf 1 24 separator 0.85162246 ¶ 2212 2214 W3003562107.pdf 1 25 text 0.9995797 "Unfortunately, the production of plastic is largely based on fossil hydrocarbons, which are non-renewableresources. If the growth in plastic production continues at the same level, by 2050 the plastic industry may account for 20% of the world’s total oil consumption [23]." 2214 2493 W3003562107.pdf 1 26 separator 0.9674498 ¶ 2493 2495 W3003562107.pdf 1 27 text 0.99933624 "Global consumption of plastic can be estimated by observing the amount of plastic waste produced. Plastic packaging is mostly single-use, especially in business-to-consumer applications, and a majority of it is discarded the same year it is produced." 2495 2752 W3003562107.pdf 1 28 separator 0.9328745 ¶ 2752 2754 W3003562107.pdf 1 29 text 0.9995061 "In 2015, plastic packaging waste accounted for 47% of the plastic waste generated globally, with half of that appearing to come from Asia. While China remains the largest worldwide generator of plastic packaging waste,the USA is the largest generator of plastic packaging waste on a per-capita basis, followed by Japan and the EU (fig. 2)" 2754 3101 W3003562107.pdf 1 30 separator 0.9967734 ¶ 3101 3103 W3003562107.pdf 1 31 title 0.9903353 International action on bags 3103 3132 W3003562107.pdf 1 32 separator 0.99225533 ¶ 3132 3134 W3003562107.pdf 1 33 text 0.99951285 "Government-led changes to reduce plastic bag consumption and litter are common internationally. Bansand levies are the most popular methods for plastic bag reduction globally (fig. 3)." 3134 3323 W3003562107.pdf 1 34 separator 0.7794299 ¶ 3323 3325 W3003562107.pdf 1 35 text 0.9995798 "In the EU, we currently use 100 billion plastic bags per year. This is a huge waste, because most of the time the bags are used only once, many ending in our oceans and seas." 3325 3506 W3003562107.pdf 1 36 separator 0.587956 ¶ 3506 3508 W3003562107.pdf 1 37 text 0.9991839 "A new measure in combating this problem raised by plastic consumption is the new EU Plastic Packaging Directive, which obliges Member States to drasticallyreduce the use of light bags." 3508 3697 W3003562107.pdf 1 38 separator 0.6299393 ¶ 3697 3699 W3003562107.pdf 1 39 text 0.99931604 "Due to the measures taken in recent years in Denmark and Finland, the average annual consumption of lightweight plastic bags is only four per person. In Ireland, since the introduction of a tax in 2002, the consumption ofdisposable plastic bags decreased from 328 people per" 3699 3980 W3003562107.pdf 1 40 separator 0.81547344 ¶ 3980 3982 W3003562107.pdf 1 41 caption 0.9887332 "Fig. 2. Plastic packaging waste generation, 2015, million MtFig. 1. Global plastic production by industrial sector, 2015" 3982 4107 W3003562107.pdf 1 42 separator 0.9963043 ¶ 4107 4109 W3003562107.pdf 1 0 paratext 0.8874788 13 0 2 W4295722753.pdf 12 1 separator 0.9915987 ¶ 3 5 W4295722753.pdf 12 2 bibliography 0.99753606 "Walach, H., Klement, R. J., & Aukema, W. (2022). The risk -benefit ratio of Covid -19 vaccines : Publication policy by retraction does nothing to improve it. Clinical and Tran slational Discovery , 2, e35. https://doi.org/10.1002/ctd2.35" 6 251 W4295722753.pdf 12 3 separator 0.9795772 ¶ 253 255 W4295722753.pdf 12 4 bibliography 0.99092925 "Walker, P. G. T., Whittaker, C., Watson, O. J., Baguelin, M., Winskill, P., Hamlet, A., ... Ghani, A. C. (2020). The impact of COVID -19 and strategies for mitigation and suppression in low - And middle-income countries. Science , 369(6502), 413 –422. https://doi.org/10.1126/science.abc0035" 255 554 W4295722753.pdf 12 5 separator 0.9826573 ¶ 556 558 W4295722753.pdf 12 6 bibliography 0.9980252 "Watson, O. J., Barnsley, G., Toor, J., Hogan, A. B., Winskill, P., & Ghani, A. C. (2022a). Global impact of the first year of COVID -19 vaccination: a mathematical mo delling study. The Lancet Infectious Diseases , 3099 (22), 1 –10. https://doi.org/10.1016/s1473 -3099(22)00320 -6" 558 845 W4295722753.pdf 12 7 separator 0.96523494 ¶ 846 848 W4295722753.pdf 12 8 bibliography 0.9979211 "Watson, O. J., Barnsley, G., Toor, J., Hogan, A. B., Winskill, P., & Ghani, A. C. (2022b). Global impact of the first year of COVID -19 vaccination: a mathematical modelling study. The Lancet Infectious Diseases , 3099 (22). https://doi.org/10.1016/s1473 -3099(22)00320 -6" 848 1128 W4295722753.pdf 12 9 separator 0.96767247 ¶ 1129 1131 W4295722753.pdf 12 10 bibliography 0.9977534 "Yamamoto, K. (2022). Adverse effects of COVID -19 vaccines and measures to prevent them. Virology Journal , 19, 100. https://doi.org/10.1 186/s12985 -022-01831 -0" 1131 1297 W4295722753.pdf 12 11 separator 0.99068063 ¶ ¶ 1298 1304 W4295722753.pdf 12 0 paratext 0.8956708 Nätynki et al. BP180 Autoantibodies in Dermatitis Herpetiformis and Coel iac Disease 0 84 W3088427357.pdf 9 1 separator 0.987654 ¶ 84 86 W3088427357.pdf 9 2 bibliography 0.9976361 "27. Tasanen K, Varpuluoma O, Nishie W. Dipeptidyl peptidase-4 inhibi tor- associated bullous pemphigoid. Front Immunol. (2019) 10:1238. doi:10.3389/fimmu.2019.01238" 86 254 W3088427357.pdf 9 3 separator 0.963588 ¶ 254 256 W3088427357.pdf 9 4 bibliography 0.997675 "28. Didona D, Di Zenzo G. Humoral epitope spreading in autoimmune bullous diseases. Front Immunol. (2018) 9:779. doi: 10.3389/fimmu.2018. 00779" 256 403 W3088427357.pdf 9 5 separator 0.972678 ¶ 403 405 W3088427357.pdf 9 6 bibliography 0.9965485 "29. Cornaby C, Gibbons L, Mayhew V, Sloan CS, Welling A, Poole BD. B cell epitope spreading: mechanisms and contribution to autoimmune diseases. Immunol Lett. (2015) 163:56–68. doi: 10.1016/j.imlet.2014. 11.001" 405 622 W3088427357.pdf 9 7 separator 0.9647479 ¶ 622 624 W3088427357.pdf 9 8 bibliography 0.9979924 "30. Messingham KAN, Aust S, Helfenberger J, Parker KL, Schultz S, McKillip J, et al. Autoantibodies to collagen XVII are present in parkinson’s dis ease and localize to tyrosine-hydroxylase positive neurons. J Invest Dermatol. (2016) 136:721–3.doi:10.1016/j.jid.2015.12.005" 624 904 W3088427357.pdf 9 9 separator 0.97640777 ¶ 904 906 W3088427357.pdf 9 10 bibliography 0.99652314 "31. Zone JJ, Schmidt LA, Taylor TB, Hull CM, Sotiriou MC, Jaskowski TD, et al. Dermatitis herpetiformis sera or goat anti-transglutaminase -3 transferred to human skin-grafted mice mimics dermatitis herpetiformis immunopathology. J Immunol. (2011) 186:4474–80. doi: 10.4049/jimmunol. 1003273" 906 1206 W3088427357.pdf 9 11 separator 0.9816111 ¶ 1206 1208 W3088427357.pdf 9 12 bibliography 0.997448 "32. Feliciani C, Caldarola G, Kneisel A, Podstawa E, Pfutze M, Pfu tzner W, et al. IgG autoantibody reactivity against bullous pemphigoid (BP) 180 a nd BP230 inelderlypatientswithpruriticdermatoses. BrJDermatol. (2009)161:306–12. doi:10.1111/j.1365-2133.2009.09266.x" 1208 1481 W3088427357.pdf 9 13 separator 0.96894336 ¶ 1481 1483 W3088427357.pdf 9 14 bibliography 0.99717134 "33. van Beek N, Dohse A, Riechert F, Krull V, Recke A, Zillikens D, et al. Serum autoantibodies against the dermal-epidermal junction in pati ents with chronic pruritic disorders, elderly individuals and blood donors prospectively recruited. Br J Dermatol. (2014) 170:943–7. doi: 10.1111/bjd. 12739" 1483 1790 W3088427357.pdf 9 15 separator 0.9785208 ¶ 1790 1792 W3088427357.pdf 9 16 bibliography 0.997789 "34. Liu Z, Chen L, Zhang C, Xiang LF. Circulating bullous pemphigoid 1 80 autoantibody can be detected in a wide spectrum of patients with other dermatologicconditions:across-sectionalstudy. JAmAcadDermatol. (2019) 80:774–5.doi:10.1016/j.jaad.2018.06.00635. Saffari H, Zone JJ, Allen M, Leiferman KM. A subset of patients with pemphigoid(herpes)gestationishasserologicalevidenceofceliac disease.Int JDermatol. (2018)57:534–40.doi:10.1111/ijd.13925" 1792 2249 W3088427357.pdf 9 17 separator 0.9839216 ¶ 2249 2251 W3088427357.pdf 9 18 bibliography 0.998003 "36. Ress K, Teesalu K, Annus T, Putnik U, Lepik K, Luts K, et al. Low prevalence ofIgAanti-transglutaminase1,2,and3autoantibodiesinchild renwithatopic dermatitis. BMCResNotes. (2014)7:310.doi:10.1186/1756-0500-7-310" 2251 2471 W3088427357.pdf 9 19 separator 0.97254163 ¶ 2471 2473 W3088427357.pdf 9 20 bibliography 0.99796164 "37. Schulze F, van Beek N, Terheyden P, Zillikens D, Schmidt E. Con comitant bullous pemphigoid and dermatitis herpetiformis. Dermatology. (2013) 226:217–21.doi:10.1159/000349982" 2473 2656 W3088427357.pdf 9 21 separator 0.96634513 ¶ 2656 2658 W3088427357.pdf 9 22 bibliography 0.99764293 "38. Hervonen K, Alakoski A, Salmi TT, Helakorpi S, Kautiainen H, Kaukinen K, et al. Reduced mortality in dermatitis herpetiformis: a population-based study of 476 patients. Br J Dermatol. (2012) 167:1331–7. doi:10.1111/j.1365-2133.2012.11105.x" 2658 2908 W3088427357.pdf 9 23 separator 0.96864617 ¶ 2908 2910 W3088427357.pdf 9 24 bibliography 0.9977995 "39. Horvath B, Niedermeier A, Podstawa E, Muller R, Hunzelmann N, Karpati S, et al. IgA autoantibodies in the pemphigoids and linear IgA bullous dermatosis. Exp Dermatol. (2010) 19:648–53. doi:10.1111/j.1600-0625.2010.01080.x" 2910 3142 W3088427357.pdf 9 25 separator 0.96829534 ¶ 3142 3144 W3088427357.pdf 9 26 bibliography 0.9979214 "40. Zone JJ, Egan CA, Taylor TB, Meyer LJ. IgA autoimmune disorder s: development of a passive transfer mouse model. J Investig Dermatol Symp Proc.(2004)9:47–51.doi:10.1111/j.1087-0024.2004.00840.x" 3144 3346 W3088427357.pdf 9 27 separator 0.98566747 ¶ 3346 3348 W3088427357.pdf 9 28 text 0.8882205 "Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be c onstrued as a potentialconflictofinterest." 3348 3542 W3088427357.pdf 9 29 separator 0.9814677 ¶ 3542 3544 W3088427357.pdf 9 30 paratext 0.80126065 Copyright © 2020 Nätynki, Tuusa, 3544 3577 W3088427357.pdf 9 31 bibliography 0.56760216 Hervon 3577 3584 W3088427357.pdf 9 32 paratext 0.64245117 en, 3584 3587 W3088427357.pdf 9 33 bibliography 0.5680816 Kaukinen 3587 3596 W3088427357.pdf 9 34 paratext 0.6948122 , 3596 3597 W3088427357.pdf 9 35 bibliography 0.7341288 Lindgren 3597 3606 W3088427357.pdf 9 36 paratext 0.67683756 , 3606 3607 W3088427357.pdf 9 37 bibliography 0.62981987 Hui 3607 3611 W3088427357.pdf 9 38 paratext 0.60758895 "laja, Ko" 3611 3622 W3088427357.pdf 9 39 bibliography 0.48639047 kkonen 3622 3628 W3088427357.pdf 9 40 paratext 0.94192415 ", Salmi and Tasanen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). T he use, distribution or reproduction in other forums is permitted, provided the or iginal author(s) and the copyright owner(s) are credited and that the original pub lication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproductionispermittedwhichdoesnotcomplywiththeset erms." 3628 4102 W3088427357.pdf 9 41 separator 0.9131323 ¶ 4102 4104 W3088427357.pdf 9 42 paratext 0.97857505 Frontiers in Immunology | www.frontiersin.org 10 September 2020 | Volume 11 | Article 575805 4104 4197 W3088427357.pdf 9 0 paratext 0.9772601 In Memoriam – Jean-Paul Mauriès91 0 33 W4387498109.pdf 4 1 separator 0.90490013 ¶ 33 35 W4387498109.pdf 4 2 bibliography 0.9857488 "1920 (Chordeumatida: Opisthocheiridae). Zootaxa 4044(3): 391–410. https://doi. org/10.11646/zootaxa.4044.3.4" 35 146 W4387498109.pdf 4 3 separator 0.98631823 ¶ 146 148 W4387498109.pdf 4 4 bibliography 0.9973699 "Gilgado JD, Ledesma E, Enghoff H, Mauriès J-P , Ortuño VM (2017) A new genus and spe- cies of Haplobainosomatidae (Diplopoda: Chordeumatida) from the MSS of the Sierra de Guadarrama National Park, central Spain. Zootaxa 4347(3): 492–510. https://doi. org/10.11646/zootaxa.4347.3.4" 148 436 W4387498109.pdf 4 5 separator 0.9831921 ¶ 436 438 W4387498109.pdf 4 6 bibliography 0.9976573 "Golovatch SI, Geoffroy J-J, Mauriès J-P (2006) Four new Chordeumatida (Diplopoda) from caves in China. Zoosystema 28(1): 75–92." 438 569 W4387498109.pdf 4 7 separator 0.97555923 ¶ 569 571 W4387498109.pdf 4 8 bibliography 0.9970537 "Golovatch SI, Geoffroy J-J, Mauriès J-P (2006) Review of the millipede genus Hyleoglomeris Verhoeff, 1910 (Diplopoda, Glomerida, Glomeridae), with descriptions of new species from caves in Southeast Asia. Zoosystema 28(4): 887–915." 571 809 W4387498109.pdf 4 9 separator 0.98285294 ¶ 809 811 W4387498109.pdf 4 10 bibliography 0.9975158 "Golovatch SI, Geoffroy J-J, Mauriès J-P (2007) Several new or poorly-known cavernicolous millipedes (Diplopoda) from southern China [for 2006]. Arthropoda Selecta 15(2): 81–89." 811 991 W4387498109.pdf 4 11 separator 0.9856066 ¶ 991 993 W4387498109.pdf 4 12 bibliography 0.99644613 "Golovatch SI, Geoffroy J-J, Mauriès J-P (2010) Review of the millipede genus Pacidesmus Golovatch 1991, with descriptions of three new species from caves in Southern China (Diplopoda: Polydesmida: Polydesmidae). T ropical Natural History 10(2): 159–169." 993 1253 W4387498109.pdf 4 13 separator 0.9844751 ¶ 1253 1255 W4387498109.pdf 4 14 bibliography 0.9975139 "Golovatch SI, Geoffroy J-J, Mauriès J-P (2010) T wo new species of the millipede genus Desmoxy- tes Chamberlin, 1923 (Diplopoda: Polydesmida: Paradoxosomatidae) from caves in south- ern China. Arthropoda Selecta 19(2): 57–61. https://doi.org/10.15298/arthsel.19.2.01" 1255 1526 W4387498109.pdf 4 15 separator 0.98830473 ¶ 1526 1528 W4387498109.pdf 4 16 bibliography 0.99699694 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2007) Review of the millipede genus Glyphiulus Gervais, 1847, with descriptions of new species from Southeast Asia (Diplopoda, Spirostreptida, Cambalopsidae). Part 1. the granulatus-group. Zoosystema 29(1): 7–49." 1528 1809 W4387498109.pdf 4 17 separator 0.97864246 ¶ 1809 1811 W4387498109.pdf 4 18 bibliography 0.9972772 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2007) Review of the millipede genus Glyphiulus Gervais, 1847, with descriptions of new species from Southeast Asia (Diplopoda, Spirostreptida, Cambalopsidae). Part 2. The javanicus-group. Zoosystema 29(3): 417–456." 1811 2094 W4387498109.pdf 4 19 separator 0.9865067 ¶ 2094 2096 W4387498109.pdf 4 20 bibliography 0.99740434 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2009) Review of the millipede genus Plusioglyphiulus Silvestri, 1923, with descriptions of new species from Southeast Asia (Diplopoda, Spirostreptida, Cambalopsidae). Zoosystema 31(1): 71–116. https://doi. org/10.5252/z2009n1a5" 2096 2391 W4387498109.pdf 4 21 separator 0.9886613 ¶ 2391 2393 W4387498109.pdf 4 22 bibliography 0.99710935 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2009) The first, new species of mil- lipede family Pyrgodesmidae to be recorded in Vanuatu, Melanesia, southwestern Pacific (Diplopoda: Polydesmida) [for 2008]. Arthropoda Selecta 17(3/4): 145–151." 2393 2655 W4387498109.pdf 4 23 separator 0.98804295 ¶ 2655 2657 W4387498109.pdf 4 24 bibliography 0.99734765 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2009) Review of the millipede fam- ily Haplodesmidae, with descriptions of some new or poorly-known species (Diplopoda, Polydesmida). [In: Golovatch SI, Mesibov R (Eds) Advances in the Systematics of Di- plopoda I]. Zookeys 7: 1–53. https://doi.org/10.3897/zookeys.7.117" 2657 2994 W4387498109.pdf 4 25 separator 0.9868418 ¶ 2994 2996 W4387498109.pdf 4 26 bibliography 0.99748963 "Golovatch SI, Geoffroy J-J, Mauriès J-P , VandenSpiegel D (2009) Review of the millipede genus Eutrichodesmus Silvestri, 1910 (Diplopoda, Polydesmida, Haplodesmidae), with de- scriptions of new species [In: Golovatch SI, Mesibov R (Eds) Advances in the Systematics of Diplopoda II]. Zookeys 12: 1–46. https://doi.org/10.3897/zookeys.12.167" 2996 3344 W4387498109.pdf 4 0 title 0.9296212 Abstract 0 8 W4214778087.pdf 1 1 separator 0.9965111 ¶ 8 10 W4214778087.pdf 1 2 text 0.9996257 "Given its inputs from auditory structures and neuromodulatory systems, the posterior tail of the stria- tum is ideally positioned to influence behavioral responses to acoustic stimuli according to context and previous rewards. Results from previous studies indicate that neurons in this striatal region display selective responses to sounds. However, it is not clear whether different striatal cell classes code for distinct features of sounds, nor how different striatal output pathways may use acoustic information to guide behavior. Here we compared the sound-evoked responses of posterior striatal neurons that form the striatal direct pathway (and express the dopamine receptor D1) to the responses of neighboring neurons in naive mice. We achieved this via optogenetic photo-identification of D1-expressing neu- rons during extracellular electrophysiological recordings in awake head-fixed mice of both sexes. We found that the frequency tuning of sound-responsive direct-pathway striatal neurons is comparable to that of their sound-responsive neighbors. Moreover, we found that both populations encode amplitude modulated sounds in a similar fashion. These results suggest that different classes of neurons in the posterior striatum of naive animals have similar access to acoustic features conveyed by the auditory system even outside the context of an auditory task." 10 1410 W4214778087.pdf 1 3 separator 0.99731934 ¶ 1410 1412 W4214778087.pdf 1 4 title 0.90388715 Introduction 1412 1425 W4214778087.pdf 1 5 separator 0.9967906 ¶ 1425 1427 W4214778087.pdf 1 6 text 0.9996199 "The striatum, as the primary input structure of the basal ganglia and a target of extensive dopaminergic inputs, is ideally positioned to influence behavioral responses to sensory stimuli according to context and previous rewards. Neurons in the posterior tail of the striatum receive numerous inputs from the auditory thalamus and the auditory cortex (Hintiryan et al., 2016; Ponvert and Jaramillo, 2019; Chen et al., 2019; Valjent and Gangarossa, 2021), and these striatal neurons display robust responses to sounds (Bordi and LeDoux, 1992; Znamenskiy and Zador, 2013; Zhong et al., 2014; Guo et al., 2018). It is not known, however, whether different striatal cell classes code for distinct features of sounds, nor how different striatal output pathways may use acoustic information to guide behavior. A key step toward understanding the processing of sounds by striatal circuits and the role of different striatal cells in auditory learning is the characterization of sound evoked responses by distinct striatal neuron classes in naive animals." 1427 2495 W4214778087.pdf 1 7 separator 0.97741985 ¶ 2495 2497 W4214778087.pdf 1 8 text 0.99963576 "The striatum, including the posterior tail portion, is composed of a range of neuron classes with different gene expression and physiological profiles, including fast-spiking parvalbumin-expressing interneurons, spontaneously active cholinergic interneurons, and the abundant principal projection neurons (Kawaguchi, 1997; Valjent and Gangarossa, 2021). The large majority of these cells are medium spiny neurons that form the two main outputs of the striatum: the direct (striatonigral) path-" 2497 2998 W4214778087.pdf 1 9 separator 0.95697045 ¶ 2998 3000 W4214778087.pdf 1 10 paratext 0.89566886 2. CC-BY 4.0 International license available under a(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted February 27, 2022. ; https://doi.org/10.1101/2022.02.26.482132doi: bioRxiv preprint 3000 3342 W4214778087.pdf 1 0 text 0.99925363 "stream of protons colliding with the membrane leads to arti ficial heating. This suggests that scattering of protons at 5 keV providesonly limited insights into the membrane ’s temperature." 0 190 W4388747377.pdf 4 1 separator 0.9402031 ¶ 190 192 W4388747377.pdf 4 2 text 0.99942374 "The large-scale corrugation of the membrane has only a minor effect on the scattering pattern. Thus, stretching the membrane asdiscussed in Nicholl et al. (2017) ;Nicholl et al. (2015) does not seem necessary. Regarding angular resolut ion, we observe that increasing the value of φresembles the effect of increasing temperature (see Supplementary Material ): at 400 μrad the intensity of the rainbow p e a k si sc o m p a r a b l et ot h a ta t T= 2000 K, cf. Figure 3 .T h e optimal resolution to study scattering of protons at 5 keV is aroundφ= 100 μrad. It can be easily realized experimentally and the resulting pattern ( Figure 2C ) is virtually indistinguishable from the one with a perfectly collimated beam ( Figure 2B ). This allows to capture all essential details of the pattern." 192 1002 W4388747377.pdf 4 3 separator 0.96470916 ¶ 1002 1004 W4388747377.pdf 4 4 text 0.9991802 "So far, we have considered a perfect crystal in a single orientation. This is motivated by advances in the synthesis of graphene [ Chen et al. (2013) ;Gao et al. (2012) ;Wu et al. (2013) ;Yan et al. (2014) ]. However, irradiating such a sample with protons at 5 keV leads to substantialdamage. If we multiply the probability to introduce defects with the 1.6 ×10 8scattered protons required to create an image in Figure 2 ,w ee n du p with 3.2 × 105additional generated vacancies. Thus, using this method to study defects and assess their conce ntration is at least questionable." 1004 1596 W4388747377.pdf 4 5 separator 0.9786488 ¶ 1596 1598 W4388747377.pdf 4 6 text 0.9996888 "Extracting information from a poly -crystalline sample with grain boundaries is even more challenging. Here, several lattices withdifferent orientations will contribu te, further obscuring the image. In the extreme case of small grain size one would expect a circularlysymmetrical image. However, if th e experiment is restricted to low doses, it should be possible to extract some information on theinteraction potential from the pos ition of the rainbow peaks before the membrane is damaged too much. The same applies to orientation of the membrane, which is encoded in the scattering pattern at least for samples with one predominant crystal orientation." 1598 2268 W4388747377.pdf 4 7 separator 0.99669147 ¶ 2268 2270 W4388747377.pdf 4 8 title 0.99202174 5 Summary and outlook 2270 2292 W4388747377.pdf 4 9 separator 0.9962777 ¶ 2292 2294 W4388747377.pdf 4 10 text 0.999761 "In summary, we have investigated classical scattering of protons through graphene. Including the temperature of the lattice by displacing the lattice atoms for each scattering event, we couldshow that the outer rainbow previously described in the literature isan artifact. In contrast to that, statistical averaging performed herequantitatively indicates the maximum level of detail that can beobserved in an experiment. Regarding thermometry, we observeonly a weak dependence of the peak positions on temperature, whichmight additionally be obscured by the angular resolution and the artificial heating due to the colliding protons. Based on this, we cannot con firm the predicted high sensitivity regarding temperature based on the contribution of in-plane and out-of-plane motion." 2294 3086 W4388747377.pdf 4 11 separator 0.7819966 ¶ 3086 3088 W4388747377.pdf 4 12 text 0.9936257 "If the dose is restricted, it should be possible to extract some information on the interaction potential and the orientation of themembrane. The possibility to study defects seems unrealistic as the method has a non-negligible probab ility for inducing defects itself. This limits the applicability of the proposed method as an analytical tool as the membrane is always c hanged during the analysis." 3088 3497 W4388747377.pdf 4 13 separator 0.9574379 ¶ 3497 3499 W4388747377.pdf 4 14 text 0.99973375 "To avoid beam damage and turn proton scattering into a useful technique, the interaction energy has to be reduced below the damagethreshold, which is predicted around 80 eV [ Brand et al. (2019) ]. In turn,this opens new vistas to study the interaction of protons with the membrane. On the one hand, neutralization will be more prominentat these energies [ Kononov and Schleife (2021) ], bringing energy- and angle-resolved neutralization studies within reach. On the other hand,exchanging protons by neutral hydrog en atoms facilitates matter-wave diffraction [ Brand et al. (2019) ]. In this case the level of detail is expected to be much higher, allowing to study elasti c and inelastic interactions in detail." 3499 4224 W4388747377.pdf 4 15 separator 0.9968858 ¶ 4224 4226 W4388747377.pdf 4 16 title 0.98982024 Data availability statement 4226 4254 W4388747377.pdf 4 17 separator 0.99276656 ¶ 4254 4256 W4388747377.pdf 4 18 text 0.995205 "The raw data supporting the conclusion of this article will be made available by the authors, without undue reservation." 4256 4379 W4388747377.pdf 4 19 separator 0.9964265 ¶ 4379 4381 W4388747377.pdf 4 20 title 0.9786188 Author contributions 4381 4402 W4388747377.pdf 4 21 separator 0.9826633 ¶ 4402 4404 W4388747377.pdf 4 22 bibliography 0.9691637 "JB: Formal Analysis, Invest igation, Software, Writing –original draft, Writing –review and editing. PR: Conceptualization, Methodology, Writing –original draft, Formal Analysis, Supervision, Writing –review and editing. CB: Conceptualiz ation, Supervision, Writing –original draft, Formal Analysis, Writing –review and editing." 4404 4741 W4388747377.pdf 4 23 separator 0.9940363 ¶ 4741 4743 W4388747377.pdf 4 24 title 0.9805536 Funding 4743 4751 W4388747377.pdf 4 25 separator 0.9897274 ¶ 4751 4753 W4388747377.pdf 4 26 text 0.99085957 "The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article." 4753 4881 W4388747377.pdf 4 27 separator 0.9950572 ¶ 4881 4883 W4388747377.pdf 4 28 title 0.9693518 Acknowledgments 4883 4899 W4388747377.pdf 4 29 separator 0.9866519 ¶ 4899 4901 W4388747377.pdf 4 30 text 0.8432236 "We thank Maxime Debiossac, Maxim Efremov, and François Aguillon for fruitful discussions." 4901 4993 W4388747377.pdf 4 31 separator 0.99588466 ¶ 4993 4995 W4388747377.pdf 4 32 title 0.9871437 Conflict of interest 4995 5015 W4388747377.pdf 4 33 separator 0.985676 ¶ 5015 5017 W4388747377.pdf 4 34 text 0.9976827 "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential con flict of interest." 5017 5193 W4388747377.pdf 4 35 separator 0.99576384 ¶ 5193 5195 W4388747377.pdf 4 36 title 0.98056376 Publisher ’s note 5195 5213 W4388747377.pdf 4 37 separator 0.9766696 ¶ 5213 5215 W4388747377.pdf 4 38 text 0.9879808 "All claims expressed in this article are solely those of the authors and do not necessarily represent those of their af filiated organizations, or those of the publisher, the editors and thereviewers. Any product that may be evaluated in this article, orclaim that may be made by its manufacturer, is not guaranteed orendorsed by the publisher." 5215 5563 W4388747377.pdf 4 39 separator 0.99509513 ¶ 5563 5565 W4388747377.pdf 4 40 title 0.97098345 Supplementary material 5565 5588 W4388747377.pdf 4 41 separator 0.9753083 ¶ 5588 5590 W4388747377.pdf 4 42 text 0.8437518 "The Supplementary Material for this article can be found online at:https://www.frontiersin.org/articles/10.3389/fchem.2023.1291065/ " 5590 5725 W4388747377.pdf 4 43 paratext 0.45854017 ¶ 5725 5726 W4388747377.pdf 4 44 text 0.45555925 full 5726 5731 W4388747377.pdf 4 45 paratext 0.5424017 # 5731 5732 W4388747377.pdf 4 46 text 0.75240326 supplementary 5732 5745 W4388747377.pdf 4 47 paratext 0.46938366 - 5745 5746 W4388747377.pdf 4 48 text 0.5032373 material 5746 5754 W4388747377.pdf 4 49 separator 0.7438572 ¶ 5754 5756 W4388747377.pdf 4 50 paratext 0.9733516 Frontiers in Chemistry frontiersin.org 05Bühler et al. 10.3389/fchem.2023.1291065 5756 5838 W4388747377.pdf 4 0 paratext 0.96525776 "ISSN: 2320 -5407 Int. J. Adv. Res. 8(06), 180-188 186" 0 132 W4287760396.pdf 6 1 separator 0.98429084 ¶ 133 135 W4287760396.pdf 6 2 title 0.8953312 Conclusion and Recommendations : - 136 171 W4287760396.pdf 6 3 separator 0.9878478 ¶ 172 174 W4287760396.pdf 6 4 text 0.99944156 "Aerosols are the major pathway of COVID -19 transmission. Thus, wearing a face mask in any public setting where social distancing is hard to do is highly recommended. Even though masks may not be perfect, current evidence generally supports their use, and taking this small precaution could help slow the pandemic. Many commonly used items, toilet facilities, and air samples had evidence of viral contamination. This indicates that SARS -CoV-2 is shed to the environment as expired particles, during toileting, and through contact with surfaces. Hence disease spread through both direct and indirect contact are confirmed, supporting the use of airborne isolation precautions." 174 867 W4287760396.pdf 6 5 separator 0.72190493 ¶ ¶ 869 875 W4287760396.pdf 6 6 text 0.99901897 "Following common sense and the guidance of public health officials is also important, including avoiding crowded indoor spaces as much as possible and practicing social distancing both inside and outdoors. Washing hands frequently and ensuring personal and environmental hygiene is of p aramount importance in minimizing the risks." 875 1214 W4287760396.pdf 6 7 separator 0.879169 ¶ ¶ 1216 1223 W4287760396.pdf 6 8 text 0.999493 "The COVID -19 would not just disappear overnight, and we have to learn to live with it by taking the necessary precautions to control its spread. Even though lockdown have made the skies in many cities are les s polluted now than they were before the pandemic, the effects of decades of exposure to air pollution would not simply disappear. The seeming improvement in air quality resulting from the lockdown may be temporary. Again, while social distancing could have an impact, and minimize the risk of COVID -19 transmission, air quality is likely to get worse again as restrictions are lifted and the economic activities resumes, unless other steps are taken. Thus, countries that have high level of air pollution need t o take environmental measures as the only enduring step in controlling the pandemic." 1223 2050 W4287760396.pdf 6 9 separator 0.98663664 ¶ ¶ 2052 2058 W4287760396.pdf 6 10 paratext 0.46307507 References :- 2058 2072 W4287760396.pdf 6 11 separator 0.9723486 ¶ 2073 2075 W4287760396.pdf 6 12 bibliography 0.99810016 "1. Ansari SA, Springthorpe VS, Sattar SA, Rivard S, Rahman M (1991); Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus -3 and rhinovirus 14. J Clin Microbiol 1991;29: pp.2115 -9." 2075 2320 W4287760396.pdf 6 13 separator 0.9064735 ¶ 2321 2323 W4287760396.pdf 6 14 bibliography 0.99815357 "2. Bean B, Moore BM, Sterner B, Peterson LR, Gerding DN, Balfour HH (1982); Survival of influenza viruses an environmental surface; J Infect Dis 1982;146: pp.47 -51." 2323 2492 W4287760396.pdf 6 15 separator 0.89011544 ¶ 2493 2495 W4287760396.pdf 6 16 bibliography 0.9981363 "3. Brauer M. (2010) ; How much, how long, what, and where: air pollution exposure assessment for epidemiologic studies of respiratory disease; Proc. Am. Thorac. Soc. 2010;7: pp.111 –115. [PubMed] [Google Scholar]" 2495 2711 W4287760396.pdf 6 17 separator 0.8847612 ¶ 2713 2715 W4287760396.pdf 6 18 bibliography 0.9980369 4. Bunge, M. (1979); Treatise on Basic Philosophy, vol. 4. Ontology II: A World of Systems, p. 61 -2. 2715 2818 W4287760396.pdf 6 19 separator 0.9167657 ¶ 2819 2821 W4287760396.pdf 6 20 bibliography 0.99735546 "5. Carbon Brief. (2020); As China Battles One of the Most Serious Virus Epidemics of the Century, the Impacts on the Country’s Energy Demand and Emissions Are Only Beginning to Be Felt. [Google Scholar]" 2821 3027 W4287760396.pdf 6 21 separator 0.9638168 ¶ 3029 3031 W4287760396.pdf 6 22 bibliography 0.9964861 "6. Calma, Justine (2020); Air quality is way better in nine major cities after coronavirus confinement; Retrieved from: https://www.theverge.com/2020/4/22/21230917/air -quality -pollution -coronavirus -lockdown -social -distancing - cities; Accessed on 05:05:2020." 3031 3302 W4287760396.pdf 6 23 separator 0.9678271 ¶ 3304 3306 W4287760396.pdf 6 24 bibliography 0.99799854 "7. Cascella, Marco; Michael Rajnik; Arturo Cuomo; Scott C. Dulebohn; Raffaela Di Napoli (2020); Features, Evaluation and Treatment Coronavirus (COVID -19); Last Update: April 6, 2020 (http://creativecommons.org/licenses/by/4.0/); Accessed 19:05:2020" 3306 3563 W4287760396.pdf 6 25 separator 0.97497654 ¶ 3565 3567 W4287760396.pdf 6 26 bibliography 0.99690694 "8. Chan J.F. -W., Yuan S., Kok K. -H., To K.K. -W., Chu H., Yang J., Xing F., Liu J., Yip C.C. -Y., Poon R.W. -S., Tsoi H.-W., Lo S.K. -F., Chan K. -H., Poon V.K. -M., Chan W. -M., Ip J.D., Cai J. -P., Cheng V.C. -C., Chen H., Hui C.K. - M., Yuen K. -Y.(2020); A familial cluster of pneumonia associated wit h the 2019 novel coronavirus indicating person -to-person transmission: a study of a family cluster. Lancet. 2020; 395: pp.514 –523. [PMC free article] [PubMed] [Google Scholar]; https://doi.org/10.1016/s0140 -6736(20) pp.30154 -9." 3567 4118 W4287760396.pdf 6 27 separator 0.95477474 ¶ 4119 4121 W4287760396.pdf 6 28 bibliography 0.9980847 "9. Chen S., Bloom D.E. (2019); The macroeconomic burden of noncommunicable diseases associated with air pollution in China; PloS One. 2019;14 [PMC free article] [PubMed] [Google Scholar]" 4121 4311 W4287760396.pdf 6 29 separator 0.9462503 ¶ 4313 4315 W4287760396.pdf 6 30 bibliography 0.9969622 "10. Chiusolo M., Cadum E., Stafoggia M., Galassi C., Berti G., Faustini A., Bisanti L., Vigotti M.A., De ssì M.P., Cernigliaro A., Mallone S., Pacelli B., Minerba S., Simonato L., Forastiere F., (2011); EpiAir Collaborative Group Short -Term effects of nitrogen dioxide on mortality and susceptibility factors in 10 Italian cities: the EpiAir study. Environ. Hea lth Perspect. 2011;119: pp.1233 –1238. [PMC free article] [PubMed] [Google Scholar]" 4315 4772 W4287760396.pdf 6 31 separator 0.9683419 ¶ 4774 4776 W4287760396.pdf 6 32 bibliography 0.99782395 "11. Cohen A.J., Brauer M., Burnett R., Anderson H.R., Frostad J., Estep K., Balakrishnan K., Brunekreef B., Dandona L., Dandona R., Feigin V., Freedman G., Hubbell B., Jobling A ., Kan H., Knibbs L., Liu Y., Martin R., Morawska L., Pope C.A., Shin H., Straif K., Shaddick G., Thomas M., van Dingenen R., van Donkelaar A., Vos T., Murray C.J.L., Forouzanfar M.H. (2017); Estimates and 25 -year trends of the global burden of disease at tributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015. Lancet. 2017;389: pp.1907 –1918. [PMC free article] [PubMed] [Google Scholar]" 4776 5409 W4287760396.pdf 6 0 paratext 0.9736035 "8 Vol:.(1234567890) Scientific RepoRtS | (2020) 10:12104 | https://doi.org/10.1038/s41598-020-68942-y www.nature.com/scientificreports/" 0 148 W3044075956.pdf 7 1 text 0.99666643 "To investigate possible effects of chronic alcohol consumption on learning curves, we then explored group differences among runs. Namely, for the variables showing significant group differences in the previous analysis we performed additional Mann–Whitney non-parametric U tests on run-specific mean values regardless of condition, as well as PF and CF mean values separately. Based on the considerable executive load of the WoF task, we also assessed possible group differences in learning abilities in terms of time needed for task execution. To this purpose, we first applied the Friedman test within each group, to highlight significant RT differences along the four runs. We then performed post-hoc analyses (Wilcoxon signed-rank test) to identify the specific run at which each group reached the maximum (i.e. fastest) performance. For each statistical analysis we performed also effect size calculation, i.e. Glass rank biserial correlation for non-parametric tests and partial eta squared for ANCOV A. Statistical analyses were performed with SPSS (IBM Corp. Released 2015. IBM SPSS Statistics for Macintosh Version 23.0. Armonk, NY: IBM Corp.) and JASP (https ://jasp-stats .org/ )." 148 1352 W3044075956.pdf 7 2 separator 0.99414515 ¶ 1352 1354 W3044075956.pdf 7 3 text 0.99952734 "Analysis of choice behaviour. We applied regression analyses, using a panel logit procedure with an indi- vidual random effect, to unveil the contribution of different choice-related emotions to decision-making perfor - mance. The panel data analysis modelled each subject as unit, and each trial as time variable. The random-effects model was used as the default model, and the parameters were estimated by maximum likelihood. We tested two models of choice, incorporating the effect of different choice variables on decision-making behaviour." 1354 1903 W3044075956.pdf 7 4 separator 0.9641304 ¶ 1903 1905 W3044075956.pdf 7 5 text 0.9967 "In the former, we modelled the effects of anticipating disappointment (d) and regret (r), alongside the maxi- mization of expected value (e) (see details in 8). The probability of choosing gamble 1 is: where s = subject, t = time and F[θ] denotes the function eθ/(1 + eθ). The variables d and r , as described in Eqs. 2 and 3, indicate the process of minimizing future disappointment and future regret, respectively; e indicates the result of maximizing expected values. x1 and y1 represent the better and worst outcome of gamble 1 ( g1), and x2 and y2 represent the better and worst outcome of gamble 2 ( g2). The probability of x1 is p and the probability of y1 is 1 – p; the probability of x2 is q, and the probability of y2 is 1 – q." 1905 2666 W3044075956.pdf 7 6 separator 0.98185843 ¶ 2666 2668 W3044075956.pdf 7 7 text 0.99945337 "In the CF condition, the optimal behaviour depends on the subject’s ability to minimize disappointment (d; Eq. 2) and regret (r; Eq. 3), while maximizing expected value (e; Eq. 4). In the PF condition, instead, subjects can only integrate in their evaluative process the effect of anticipated disappointment and maximization of expected values (see details in 8)." 2668 3043 W3044075956.pdf 7 8 separator 0.98180676 ¶ 3043 3045 W3044075956.pdf 7 9 text 0.99686503 "The second model aimed to investigate the modulation of choice behaviour by the affective experience asso- ciated with a near-miss outcome (NM) in the previous trial, in addition to the maximization of expected value (e). Therefore, choice behaviour depends a) both on the maximization of expected value (Eq. 4) and near-miss outcome of both gambles in the CF condition; b) only on expected value and near-miss of the chosen gamble in the PF condition. The probability of choosing g 1 is: where the NM regressor included three possible values, depending on the proportional distance between the rest - ing position of the spinning arrow and the boundaries between the best and worse gamble outcomes. Therefore, the participants could experience a ""clear"" outcome, when the arrow stopped in the central area of the best or worse gamble segments; a full near-miss outcome, when it stopped very close to the boundary between them; and a partial near-miss outcome, when it stopped in an approximately intermediate area between the former positions." 3045 4104 W3044075956.pdf 7 10 separator 0.9786775 ¶ 4104 4106 W3044075956.pdf 7 11 text 0.7750841 "The analysis of choice behaviour was carried out with STATA (StataCorp. 2019. Stata Statistical Software: Release 13 . College Station, TX: StataCorp LLC.)." 4106 4267 W3044075956.pdf 7 12 separator 0.8685039 ¶ 4267 4269 W3044075956.pdf 7 13 paratext 0.9855088 Received: 2 March 2020; Accepted: 25 June 2020 4269 4316 W3044075956.pdf 7 14 separator 0.9718522 ¶ 4316 4318 W3044075956.pdf 7 15 title 0.8273734 References 4318 4329 W3044075956.pdf 7 16 separator 0.9912432 ¶ 4329 4331 W3044075956.pdf 7 17 bibliography 0.9978637 "1. Ernst, M. & Paulus, M. P . Neurobiology of decision making: a selective review from a neurocognitive and clinical perspective. Biol. Psychiatry 58, 597–604 (2005)." 4332 4503 W3044075956.pdf 7 18 separator 0.901183 ¶ 4503 4505 W3044075956.pdf 7 19 bibliography 0.9981617 2. Liu, X., Hairston, J., Schrier, M. & Fan, J. Common and distinct networks underlying reward valence and processing stages: a meta-analysis of functional neuroimaging studies. Neurosci. Biobehav. Rev. 35, 1219–1236 (2011). 4506 4732 W3044075956.pdf 7 20 separator 0.8888014 ¶ 4732 4734 W3044075956.pdf 7 21 bibliography 0.9978276 "3. Rogers, R. D. et al. Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J. Neurosci. 19, 9029–9038 (1999)." 4735 4914 W3044075956.pdf 7 22 separator 0.93898475 ¶ 4914 4916 W3044075956.pdf 7 23 bibliography 0.99768406 "4. Brand, M., Labudda, K. & Markowitsch, H. J. Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Networks 19, 1266–1276 (2006)." 4917 5089 W3044075956.pdf 7 24 separator 0.904606 ¶ 5089 5091 W3044075956.pdf 7 25 bibliography 0.99805117 5. Lawrence, A., Clark, L., Labuzetta, J. N., Sahakian, B. & Vyakarnum, S. The innovative brain. Nature 456, 168–169 (2008). 5092 5218 W3044075956.pdf 7 26 separator 0.86075103 ¶ 5218 5220 W3044075956.pdf 7 27 bibliography 0.9855358 6. Camille, N. et al. The involvement of the orbitofrontal cortex in the experience of regret. Science (80-) 304, 1167–1170 (2004).(1) 5221 5358 W3044075956.pdf 7 28 math 0.9634206 "Pr/parenleftbig g1st/parenrightbig =1−Pr/parenleftbig g2st/parenrightbig =F[dst;rst;est] (2) d=/parenleftbig y2−x2∨/parenleftbig 1−q/parenrightbig/parenrightbig −/parenleftbig y1−x1∨/parenleftbig 1−p/parenrightbig/parenrightbig (3) r=/vextendsingle/vextendsingley2−x1/vextendsingle/vextendsingle−/vextendsingle/vextendsingley1−x2/vextendsingle/vextendsingle (4) e=EV/parenleftbig g1/parenrightbig −EV/parenleftbig g2/parenrightbig =/parenleftbig px1+/parenleftbig 1−p/parenrightbig y1/parenrightbig −/parenleftbig qx2+/parenleftbig 1−q/parenrightbig y2/parenrightbig Pr/parenleftbig g1st/parenrightbig =1−Pr/parenleftbig g2st/parenrightbig =F[NM st;est]" 5358 6068 W3044075956.pdf 7 0 paratext 0.9908135 Page 7 of 10 0 12 W4317895761.pdf 6 1 separator 0.81275135 ¶ 12 14 W4317895761.pdf 6 2 paratext 0.98414546 Cardoso Pinto et al. BMC Medical Education (2023) 23:56 15 81 W4317895761.pdf 6 3 separator 0.93867993 ¶ ¶ 82 88 W4317895761.pdf 6 4 text 0.99072206 "personalised teaching and therefore both a unique expe - rience for pupils and a more enjoyable experience for themselves. “being able to like use like physical stuff to interact with them (...) I think that’s what really makes TBH so special. ” (VP3)." 88 352 W4317895761.pdf 6 5 separator 0.9898454 ¶ 352 354 W4317895761.pdf 6 6 text 0.9982397 "Lockdowns drastically changed the nature of the uni - versity experience; in this context volunteer participants noted the benefits to their mental health of partaking in online volunteering." 354 554 W4317895761.pdf 6 7 separator 0.5260554 ¶ 554 556 W4317895761.pdf 6 8 text 0.9994151 "“From the whole situation that we were going through in lockdown (...) I think mentally it was one of the things that kept me sane in it (...) I had a moment where I felt that I was doing something good for other people, not related to academics” (VP11)." 556 819 W4317895761.pdf 6 9 separator 0.90704465 ¶ 819 821 W4317895761.pdf 6 10 text 0.99938095 "Volunteer participants enjoyed “seeing the kids (...) [who] have lots of energy (...) and it was nice to feed off that when it was locked down as you weren’t seeing many people” (VP7). Online also offered a space to “de-stress (...) [by] working with kids (...) which takes your mind off (...) other issues” (VP11)." 821 1144 W4317895761.pdf 6 11 separator 0.9712035 ¶ 1144 1146 W4317895761.pdf 6 12 text 0.9995579 "Nevertheless, university teaching was also transferred online, meaning that ICSM-TBH shifting online was yet “another stare-at-screen session” (VP10). In-person vol - unteering offers a “good [opportunity] to get out of the house” whereas online sessions could “feel very weird in the sense that you do it from your own room, as opposed to physically going to the session and getting excited about speaking to all those 5-6-year-olds” (VP4)." 1146 1608 W4317895761.pdf 6 13 separator 0.99713516 ¶ 1608 1610 W4317895761.pdf 6 14 title 0.98772883 (xxii) Workload 1611 1627 W4317895761.pdf 6 15 separator 0.9950665 ¶ 1627 1629 W4317895761.pdf 6 16 text 0.9996372 "The pandemic changed the nature of work for univer - sity students; working from home was often “mentally stressful” . Online sessions were a “really fun experience” and a “nice kind of break from uni” (VP12), however sometimes it could be “a bit challenging to find motiva - tion to join”, as “you had been in front of your computer for the entire morning and will be for the entire afternoon for the last five days. So, everything feels like effort and dif - ficult to enjoy” (VP6). In-person sessions allowed volun - teers to “split up [their] day a bit more as you have to go in-person instead of everything being online” (VP1)." 1629 2288 W4317895761.pdf 6 17 separator 0.9545364 ¶ 2288 2290 W4317895761.pdf 6 18 text 0.99962705 "Convenience was a crucial benefit highlighted in online volunteering as it is “less time intensive” and “easier to fit into schedules” due to not having travel time and making it “easier to commit to sessions” (VP12). In-person volun - teering required travelling “which can impede how many people can turn up” and can force volunteers to rush from lectures or clinical placements which can be physi - cally and mentally exhausting. Online platforms allowed volunteers to multitask and do things like “eat lunch during sessions” or “do your laundry whilst it is going on” whereas in-person “often took place over lunch times” which disrupted eating schedules for participants (VP10)." 2290 3002 W4317895761.pdf 6 19 separator 0.9968314 ¶ 3002 3004 W4317895761.pdf 6 20 title 0.9879222 Discussion 3004 3015 W4317895761.pdf 6 21 separator 0.9956008 ¶ 3015 3017 W4317895761.pdf 6 22 text 0.999592 "This study explored volunteer and teacher perspectives on the value of online versus in-person volunteering with ICSM-TBH. Overall, both online and in-person volun - teering showed social and wellbeing benefits and offered opportunities to develop a variety of professional skills for volunteers. However, for volunteers who experienced both formats, in-person sessions were preferred. Volun - teers and teachers agreed that in-person sessions pro - vided a more effective learning experience for the pupils." 3017 3547 W4317895761.pdf 6 23 separator 0.96504873 ¶ 3548 3550 W4317895761.pdf 6 24 text 0.99958885 "In the context of the national lockdowns and government restrictions, this study demonstrated that online volun - teering was an overall positive experience, as it offered a space for socialisation, allowed volunteers to gain a sense of fulfilment and provided a convenient and safe option to volunteer. This study is particularly interesting as it demonstrates that many benefits of volunteering [14] can be obtained online and outside the clinical context. Both modalities were perceived to offer skill development and offer benefits for volunteers’ future professions, espe - cially those interested in paediatrics as a speciality." 3550 4213 W4317895761.pdf 6 25 separator 0.98670137 ¶ 4213 4215 W4317895761.pdf 6 26 text 0.999585 "The opportunity to socialise through online volun - teering was essential, particularly at a time where there were limited social interactions and poor mental health [21]. Online volunteering is helpful when there are no viable alternatives, for example, due to lockdowns or to engage with children who are at high medical risk [22]." 4215 4563 W4317895761.pdf 6 27 separator 0.88420296 ¶ 4564 4566 W4317895761.pdf 6 28 text 0.99966663 "Furthermore, whilst to the authors’ knowledge there have been no studies on the impact of online commu - nity non-clinical volunteering on student wellbeing dur - ing the pandemic, previous studies have highlighted that volunteering in hospital settings during the pandemic increased university students’ sense of wellbeing [14]." 4566 4909 W4317895761.pdf 6 29 separator 0.7494503 ¶ 4910 4912 W4317895761.pdf 6 30 text 0.99965763 "This is, in part, due to the feeling of being helpful dur - ing the COVID-19 pandemic [14] – a very similar finding to this study. Volunteering may also have supported stu - dents in feeling as though they belonged to a community, which is particularly important at times of social isola - tion. Nevertheless, volunteers did suggest that this sense of enjoyment and community was greater in-person than online. Furthermore, only a subset of ICSM-TBH volun - teers took part in this research; these may be volunteers who are highly engaged with the society and therefore demonstrate a stronger sense of enjoyment and commu - nity than less committed volunteers." 4912 5601 W4317895761.pdf 6 31 separator 0.9913511 ¶ 5601 5603 W4317895761.pdf 6 32 text 0.9991027 "An important consideration is the impact of screen - time on volunteers’ health and wellbeing. During the pandemic, most teaching was online, and overall screen - time increased. The introduction of online volunteering" 5603 5829 W4317895761.pdf 6 0 table 0.9096368 "KO CM KO FAWT CM WT FA-dyeA KO CM KO FAWT CM WT FA-dyeC" 0 65 W4362528862.pdf 0 1 separator 0.842795 ¶ 65 67 W4362528862.pdf 0 2 table 0.46828818 B 67 69 W4362528862.pdf 0 3 separator 0.9939265 ¶ 69 71 W4362528862.pdf 0 4 caption 0.9825879 "Figure S1: HILPDA-dependent fatty acid storage. A) FACS analysis of BODIPY 493/503 stained MEFs in complete media (CM) or loaded with fatty acids (FA) for 24h. B) Fractional distribution of lipid droplet diameters in MEFs grown in complete media or FA loaded. Small: <150nm, Intermediate: 150-650nm, Large: >650nm. C) Nile Red staining of HCT116 HILPDA WT and KO cells following loading with FA for 24h. D) FACS analysis of BODIPY 493/503 stained HILPDA WT and KO HCT116 cells in complete media or FA loaded for 24h." 71 600 W4362528862.pdf 0 5 separator 0.98817754 ¶ 601 603 W4362528862.pdf 0 6 text 0.36948135 WTKOD 603 609 W4362528862.pdf 0 0 title 0.87530917 "Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes" 0 138 W2002892844.pdf 0 1 separator 0.9589866 ¶ 138 140 W2002892844.pdf 0 2 contact 0.9857833 "Antje Bruckbauer *, Michael B. Zemel Research and Development, NuSirt Sciences Incorporated, Knoxville, Tennessee, United States of America" 140 282 W2002892844.pdf 0 3 separator 0.9915626 ¶ 282 284 W2002892844.pdf 0 4 title 0.8671378 Abstract 284 293 W2002892844.pdf 0 5 separator 0.99545 ¶ 293 295 W2002892844.pdf 0 6 text 0.99952 "The AMPK-Sirt1 pathway is an important regulator of energy metabolism and therefore a potential target for prevention and therapy of metabolic diseases. We recently demonstrated leucine and its metabolite b-hydroxy- b-methylbutyrate (HMB) to synergize with low-dose resveratrol (200 nM) to activate sirtuin signaling and stimulate energy metabolism. Here we show that leucine exerts a direct effect on Sirt1 kinetics, reducing its Km for NAD+by.50% and enabling low doses of resveratrol to further activate the enzyme (p = 0.012). To test which structure elements of resveratrol are necessary forsynergy, we assessed potential synergy of structurally similar and dissimilar polyphenols as well as other compoundsconverging on the same pathways with leucine using fatty acid oxidation (FAO) as screening tool. Dose-response curves for FAO were constructed and the highest non-effective dose (typically 1–10 nM) was used with either leucine (0.5 mM) or HMB (5mM) to treat adipocytes and myotubes for 24 h. Significant synergy was detected for stilbenes with FAO increase in adipocytes by 60–70% (p ,0.05) and in myotubes .2000% (p ,0.01). Sirt1 and AMPK activities were stimulated by ,65% (p,0.001) and ,50% (p,0.03), respectively. Similarly, hydroxycinnamic acids and derivatives (chlorogenic, cinnamic, and ferulic acids) combined with leucine/HMB increased FAO (300–1300%, p ,0.01), AMPK activity (50–150%, p ,0.01), and Sirt1 activity ( ,70%, p,0.001). In contrast, more complex polyphenol structures, such as ellagic acid and epigallocatechin gallate required higher concentrations ( .1mM) and exhibited little or no synergy. Thus, the six-carbon ring structure bound to a carboxylic group seems to be a necessary element for leucine/HMB synergy with other stilbenes and hydroxycinnamic acids to stimulate AMPK/Sirt1 dependent FAO; these effects occur at concentrations that produce no independent effects and are readily achievable via oral administration." 295 2284 W2002892844.pdf 0 7 separator 0.9927722 ¶ 2284 2286 W2002892844.pdf 0 8 paratext 0.8971926 "Citation: Bruckbauer A, Zemel MB (2014) Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes. PLoS ONE 9(2): e89166. doi:10.1371/journal.pone.0089166" 2286 2520 W2002892844.pdf 0 9 separator 0.87604845 ¶ 2520 2522 W2002892844.pdf 0 10 paratext 0.6773242 Editor: 2522 2530 W2002892844.pdf 0 11 contact 0.74947083 Krisztian Stadler, Pennington Biomedical Research Center, United States of America 2530 2613 W2002892844.pdf 0 12 separator 0.7157328 ¶ 2613 2615 W2002892844.pdf 0 13 paratext 0.9848747 Received September 11, 2013; Accepted January 16, 2014; Published February 14, 2014 2615 2699 W2002892844.pdf 0 14 separator 0.8463516 ¶ 2699 2701 W2002892844.pdf 0 15 paratext 0.97238994 "Copyright: /C2232014 Bruckbauer, Zemel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited." 2701 2979 W2002892844.pdf 0 16 separator 0.9910197 ¶ 2979 2981 W2002892844.pdf 0 17 text 0.3913894 Fund 2981 2986 W2002892844.pdf 0 18 title 0.43474206 ing 2986 2989 W2002892844.pdf 0 19 text 0.9639236 ": This project was internally funded by NuSirt Sciences, Inc. No external sponsors or funders were involved. The funder NuSirt Sciences Inc. played no r ole in study design, data collection and analysis, and the preparation of the manuscript. The funder approved the publication of the manuscript." 2989 3288 W2002892844.pdf 0 20 separator 0.97873425 ¶ 3288 3290 W2002892844.pdf 0 21 text 0.9839447 "Competing Interests: Both authors are employees and stockholders of NuSirt Sciences, Inc, and hold patents related to the reported research, as noted in the Competing Interests section of the online submission. In addition, this research was supported by NuSirt Sciences, Inc., This does not alter the auth ors’ adherence to all the PLOS ONE policies on sharing data and materials." 3290 3676 W2002892844.pdf 0 22 separator 0.96976495 ¶ 3676 3678 W2002892844.pdf 0 23 contact 0.99579924 * E-mail: abruckbauer@nusirt.com 3678 3711 W2002892844.pdf 0 24 separator 0.99636877 ¶ 3711 3713 W2002892844.pdf 0 25 title 0.91248065 Introduction 3713 3726 W2002892844.pdf 0 26 separator 0.995367 ¶ 3726 3728 W2002892844.pdf 0 27 text 0.9993767 "AMP-activated protein kinase (AMPK) and the sirtuins Sirt1 and Sirt3 are well-known key sensors of energy status andregulators of glucose and lipid metabolism [1–3]. They work in afinely tuned network with the peroxisome proliferator activatedreceptor cco-activator 1 a(PGC-1 a) to regulate mitochondrial proliferation and metabolism and energy expenditure [4,5].Accordingly, this network appears to be a strong target forprevention and control of metabolic diseases such as obesity anddiabetes." 3728 4228 W2002892844.pdf 0 28 separator 0.9028163 ¶ 4228 4230 W2002892844.pdf 0 29 text 0.9997336 "The polyphenol resveratrol (Resv), found in the skin of red grapes and other fruits, has been reported to be a Sirt1 activator,mimicking the effects of caloric restriction on life span, oxidativeand inflammatory stress, as well as improving insulin sensitivityand reducing adiposity [6,7]. However, Sirt1 activation by Resvhas been suggested by some to be a measurement artifact, as direct Sirt1 activation demonstrated with a fluorophore-linked enzyme activity assay (Fleur-de-Lys assay) was dependent on the presenceof the fluorophore [8,9]. In contrast, recent data indicates that,depending on the substrate, the fluorophore was substituting for endogenously present hydrophobic amino acids such as leucine tolink Resv with the substrate to activate Sirt1 [10]. In addition,there is evidence for an indirect Sirt1 activation mediated byinhibiting cAMP phosphodiesterase, which results in upregulationof AMPK and a subsequent increase in NAD +levels [11]." 4230 5198 W2002892844.pdf 0 30 separator 0.9132818 ¶ 5198 5200 W2002892844.pdf 0 31 text 0.99971956 "However, this was shown to be the case only at high concentra-tions (50 mM) that are not achieved invivo, while lower concentrations lead to direct Sirt1 activation [12]. Thus, thesedifferent modes of action may explain reports of Resv’s dose- andtime- dependent effects, which lead to different outcomes in cell and animal studies. However, studies in humans are very limited and results from cell and animals studies are not readily translated,since, due to the low bioavailability of Resv, plasma concentrationsachieved with oral supplementation are much lower than thoseused in vitro ." 5200 5796 W2002892844.pdf 0 32 separator 0.96152496 ¶ 5796 5798 W2002892844.pdf 0 33 text 0.99937373 "We have previously demonstrated that the branched-chain amino acid leucine (Leu), as well as its metabolites b-hydroxy- b- methylbutyrate (HMB) and a-ketoisocaproate (KIC), directly activate recombinant human Sirt1 enzyme by 30 to 100% [13]." 5798 6046 W2002892844.pdf 0 34 separator 0.99404895 ¶ 6046 6048 W2002892844.pdf 0 35 paratext 0.9804628 PLOS ONE | www.plosone.org 1 February 2014 | Volume 9 | Issue 2 | e89166 6048 6121 W2002892844.pdf 0 0 text 0.9957167 "used for data assimilation is thus recommended, assigning information about the statistical properties of the heterogeneity that is available." 0 144 W4309822026.pdf 29 1 separator 0.9964597 ¶ 144 146 W4309822026.pdf 29 2 title 0.99044 5 Conclusions 146 160 W4309822026.pdf 29 3 separator 0.9946229 ¶ 160 162 W4309822026.pdf 29 4 text 0.9996851 "In this study, the ensemble Kalman filter was applied to a three-dimensional hillslope model to assimilate soil moisture. The augmented state vector approach was used to investigate the influence of parameter updates on the soil moisture estimates. To 605 this purpose two reference models were created, one with a homogeneous soil and the other one with two heterogeneous soil layers. These models provided synthetic observations for the assimilation and validation of the data assimilation runs." 162 664 W4309822026.pdf 29 5 separator 0.963571 ¶ 664 666 W4309822026.pdf 29 6 text 0.9989433 "A previous sensitivity analysis revealed the saturated hydraulic conductivity, porosity and the van Genuchten model param- etersαandnto be the most sensitive parameters with respect to soil moisture while the remaining parameters had a negligible influence. An ensemble was generated for each reference model by perturbing the four sensitive parameters representing the 610 uncertainty of these parameters. Then, a data assimilation run was performed for each possible combination of parameter up- dates to investigate the impact of the individual parameter updates on the soil moisture estimates. It was shown that for both scenarios, homogeneous and heterogeneous, the joint update of states (soil moisture) and the uncertain parameters improved the soil moisture estimates compared to runs without parameter updates. While updating the saturated hydraulic conductivity turned out to be less important, the update of porosity and the van Genuchten model parameters were essential. Furthermore, 615 the parameter updates improved the numerical stability of the ensemble resulting in a reduction of run time and consumed computational resources. It was further shown that a simplified representation of the heterogeneous soil structure leads to sig- nificantly worse estimates of local soil moisture values and filter divergence while it gave comparable results for estimates of averaged soil moisture when including parameter updates. Ignoring heterogeneous structures in data assimilation is therefore only recommended if the aim of the model is to estimate cumulative quantities. 620" 666 2273 W4309822026.pdf 29 7 separator 0.9826236 ¶ 2273 2275 W4309822026.pdf 29 8 text 0.9997428 "One issue that we encountered is that the improvement by the filter updates in heterogeneous soils is mostly limited to the observation locations and a small area around them. Estimates at more distant locations are still highly uncertain after the assimilation. More information is needed to overcome this problem. This can be achieved by using a denser measurement network. However, it is hardly feasible to install a monitoring network with the required density in a real field application." 2275 2773 W4309822026.pdf 29 9 separator 0.55990016 ¶ 2773 2775 W4309822026.pdf 29 10 text 0.9993037 "Instead, the additional assimilation of remotely sensed data or observations from cosmic ray probes can be an option. Besides, 625 the studies by e.g. Shi et al. (2015) and Zhang et al. (2018) indicate that additional measurements of groundwater level may help improve the soil moisture estimates." 2775 3077 W4309822026.pdf 29 11 separator 0.9233807 ¶ 3077 3079 W4309822026.pdf 29 12 text 0.9989463 "Generally, the present study has shown that whenever the soil structure can be represented accurately in the ensemble (as e.g. in homogeneous soils), parameter updates are able to improve state estimates with optimally conditioned parameter estimates reducing the model error caused by parameter uncertainty significantly. Yet, soil heterogeneity produces additional uncertainty 630 in the model which needs to be accounted for. In this work, this was done by updating the fully heterogeneous parameter fields." 3079 3594 W4309822026.pdf 29 13 separator 0.6016239 ¶ 3594 3596 W4309822026.pdf 29 14 text 0.9875672 "Thus, the assimilation can reduce the model error caused by the soil heterogeneity as much as the observations allow for. By applying a simplified soil structure, this error can only be reduced to a very limited extent due to the insufficient degrees" 3596 3847 W4309822026.pdf 29 15 separator 0.9638219 ¶ 3847 3849 W4309822026.pdf 29 16 paratext 0.98797005 30https://doi.org/10.5194/hess-2022-311 3849 3889 W4309822026.pdf 29 17 separator 0.5909955 3889 3890 W4309822026.pdf 29 18 paratext 0.9592731 "¶ Preprint. Discussion started: 26 September 2022 c Author(s) 2022. CC BY 4.0 License." 3890 3978 W4309822026.pdf 29 19 separator 0.9946509 ¶ 3978 3980 W4309822026.pdf 29 0 separator 0.5729734 ¶ 1 2 W4285817503.pdf 1 1 paratext 0.64156705 "¶ ¶ ¶ ¶" 4 27 W4285817503.pdf 1 2 separator 0.54440796 29 30 W4285817503.pdf 1 3 paratext 0.942735 "¶ 102 Arranz et al. 2022 - LimnoFish 8 (2): 101-115" 30 86 W4285817503.pdf 1 4 separator 0.97692156 ¶ ¶ 87 94 W4285817503.pdf 1 5 title 0.93990415 Introduction 94 107 W4285817503.pdf 1 6 separator 0.9930942 ¶ 109 111 W4285817503.pdf 1 7 text 0.9995581 "Arctic biomes have been profoundly modified by global warming as the increased air temperature and ice cover retreat have altered the structure and functioning of food webs (Quinlan et al. 2005; Kortsch et al. 2015; Coumou et al. 2018). Arctic charr (Salve linus alpinus , hereafter charr) plays a key role in structuring Arctic food webs by interacting across multiple trophic levels, coupling benthic –pelagic compartments and maintaining community stability (Eloranta et al. 2013; Jeppesen et al. 2017). So far, however, the combined impact of lake morphology and ecological interactions with other sympatric fish species is a little studied subject, although it may determine the charr population structure in species - poor oligotrophic high -latitude lakes (Eloranta e t al. 2015; Knudsen et al. 2016)." 111 964 W4285817503.pdf 1 8 separator 0.8793226 ¶ 966 968 W4285817503.pdf 1 9 text 0.99971056 "Arctic food webs are relevant model systems for evaluating ecological interactions because of their relatively low species diversity and simple structure (Jeppesen et al. 2017; Rolls et al. 2017). In Greenland lakes, charr is commonly the sole fish species, but it often lives in sympatry with three -spined stickleback (Gasterosteus aculeatus , hereafter stickleback) at lower latitudes in Greenland (Wootton 1985; Laske et al. 2019). However, the strength of the charr and stick leback interactions is body -size dependent because charr undergoes ontogenetic trophic shifts following a positive trophic -level –body -size relationship (i.e., trophic level increasing with body size), as demonstrated by many animal taxa but particularly by salmonids (McCann et al. 2005; Romanuk et al. 2011) . Typically, adult charr is the top predator in Arctic food webs, feeding on small - sized fish species such as sticklebacks (Jeppesen et al. 2017), but cannibalism among charr also occurs (Amundsen 2016). Given that young and small -sized charr may share sim ilar food resources with sticklebacks in the littoral zone, small -sized charr and sticklebacks are usually segregated by microhabitat feeding site selection, with sticklebacks feeding on small benthic microcrustaceans and small charr usually on chironomids or zooplankton (Jørgensen and Klemetsen 1995). Given the fact that sticklebacks affect the ontogenetic niche shifts of other salmonids such as brown trout Salmo trutta (Sánchez -Hernández et al. 2017), stickleback presence might influence the trophic posit ion (TP) of charr populations in Arctic lakes." 968 2680 W4285817503.pdf 1 10 separator 0.97834265 ¶ 2682 2684 W4285817503.pdf 1 11 text 0.99971 "A key environmental factor controlling the ecological interactions among species is habitat morphology – defined as the ecosystem size or the space where a species performs its ecological activities (Connell 1 961). Controlling for environmental conditions is important to understand ecological interactions, as e.g. interspecific competition strength may change due to the la ”ke morphology (Post et al. 2000; Eloranta et al. 2015)." 2684 3139 W4285817503.pdf 1 12 separator 0.9305819 ¶ 3140 3142 W4285817503.pdf 1 13 text 0.9996857 "Lake morphology has been observed as a key driver of charr TP, in which charr populations display high foraging plasticity and occupy different niches at large ecosystem size (Adams and Huntingford 2002; Eloranta et al. 2015; Doenz et al. 2019). Moreover, lake morphology modifies the cros s-habitat linkages between littoral and pelagic food web compartments and the charr food resources ( Murdoch and Power 2013; Eloranta et al. 2015). However, conflicting effects of lake morphology on the food chain length have been observed because of the co mplexity of food webs (Eloranta et al. 2010; Murdoch and Power 2013 ) and also due to the lack of studies using the same compositional communities. Therefore, it is a priority to develop approaches that are universal enough to include the differences in env ironmental conditions among lakes in order to identify general mechanisms driving changes in the trophic ecology in fish." 3142 4125 W4285817503.pdf 1 14 separator 0.9620297 ¶ 4127 4129 W4285817503.pdf 1 15 text 0.9995183 "In the present study, we investigated the role of lake morphology and ecological interactions with sticklebacks on charr TP in Arctic lakes and, with this, the food web structure and food chain length." 4129 4340 W4285817503.pdf 1 16 separator 0.9483985 ¶ 4341 4343 W4285817503.pdf 1 17 text 0.99955237 "The studied Arctic lakes are excellent model systems for assessing trophic interactions under both allopatric (only charr populations) and sympatric (charr populations co -occurring with st icklebacks) community compositions. We used a Bayesian Stable Isotope Mixing Model ( i) to estimate the TP (from δ15N and δ13C) of the two fish species in nine Greenland lakes and ( ii) to assess the effects of lake morphology and stickleback presence on the TP of the model organism. We hypothesized that lake morphology (defined here as the living space where a species performs their ecological activities; Connell 1961) would be positively related to the food chain length, resulting in enhanced TP of the top predator; i.e., the ecosystem -size hypothesis (Post et al. 2000; Eloranta et al. 2015). We also tested the hypothesis that the ecological role of charr would be influenced by lake morphology through biotic interactions triggering ontogenetic shifts (hereafter the trophic - ontogenetic hypothesis; Sánchez -Hernández et al. 2017; Ka hilainen et al. 2019; Klobucar and Budy 2020). To support this hypothesis, we predicted that the TP and population density of sticklebacks would trigger a switch to charr trophic level during their ontogeny/development, leading to a higher TP." 4343 5698 W4285817503.pdf 1 18 separator 0.99560547 ¶ 5700 5702 W4285817503.pdf 1 19 title 0.9926462 Materials an d Methods 5702 5725 W4285817503.pdf 1 20 separator 0.8336531 ¶ 5727 5729 W4285817503.pdf 1 21 title 0.9892193 Study Site 5729 5740 W4285817503.pdf 1 22 separator 0.99227333 ¶ 5742 5744 W4285817503.pdf 1 23 text 0.9992194 "Nine lakes were studied along the coast of western Greenland (latitudinal and longitudinal gradients 64°  76°N and 51° 54°E, respectively;" 5744 5891 W4285817503.pdf 1 0 paratext 0.9489424 38. 2019. . 0 53 W2965397497.pdf 3 1 separator 0.81031466 ¶ 55 57 W2965397497.pdf 3 2 paratext 0.9635692 127 57 61 W2965397497.pdf 3 3 separator 0.5872209 "¶ ¶" 62 73 W2965397497.pdf 3 4 bibliography 0.38443688 73 74 W2965397497.pdf 3 5 paratext 0.38486677 - 74 75 W2965397497.pdf 3 6 separator 0.46325853 ¶ 76 78 W2965397497.pdf 3 7 bibliography 0.4159556 80 81 W2965397497.pdf 3 8 separator 0.4371221 ¶ ¶ 81 86 W2965397497.pdf 3 9 bibliography 0.8602546 "[19, 231]." 86 101 W2965397497.pdf 3 10 separator 0.49867296 ¶ 102 104 W2965397497.pdf 3 11 bibliography 0.94384927 [28, 6]. 104 114 W2965397497.pdf 3 12 separator 0.6128638 ¶ 115 117 W2965397497.pdf 3 13 bibliography 0.85256314 "IV) - ¶ [25, 773]." 117 146 W2965397497.pdf 3 14 separator 0.46878576 ¶ 147 149 W2965397497.pdf 3 15 bibliography 0.83993345 "¶ - - - [21, 185-186]." 151 185 W2965397497.pdf 3 0 table 0.9800933 "unc-31 ;wwEx66 dcap-1 ;unc-31 ;wwEx66Days of adulthoodRelative Intensity Total ins-7p::gfp fluorescence (unc-31 background) C 0 1 2 3 4 5 6 7 8 9 10 110123456 unc-13 ;wwEx66 dcap-1 ;unc-13 ;wwEx66Days of adulthoodRelative Intensity Total ins-7p::gfp fluorescence (unc-13 background) D 0 1 2 3 4 5 6 7 8 9 10 110123456 ****** ** ins-7 ;wwEx66 dcap-1 ;ins-7 ;wwEx66Days of adulthoodRelative Intensity Total ins-7p::gfp fluorescence (ins-7 background) F 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 150123456 Days of adulthood%Survival Post-developmental ins-7 RNAi H 0 5 10 15 20 25 30 35 40020406080100 wt wt; ins-7(RNAi) ** synEx345 ;ins-7 (RNAi)synEx345 ns Relative mRNA levels ins-7 daf-28 ins-33 ins-1 ins-6wt dcap-1 synEx293 A 1 day 9 days 1 day 9 days 1 day 9 days 1 day 9 days 1 day 9 days13579111315 ***** 0 wt; wwEx66 dcap-1 ;wwEx66Days of adulthoodRelative Intensity Total ins-7p::gfp fluorescence B 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 1502460246 *********** ** ** * Neuonal ins-7p::gfp fluorescence E Relative mRNA levels ins-7(mRNA) 9 days old wt dcap-1dcap-1; synEx293dcap-1; synEx328***** 01234 1 day 9 days02468Relative mRNA levels**G Neuronal ins-7(mRNA) dcap-1;ins-7;synEx478 ins-7;synEx478" 0 1275 W3021931547.pdf 5 1 separator 0.98673797 ¶ 1276 1278 W3021931547.pdf 5 2 caption 0.995074 "Figure 3. Neuronal dcap-1 regulates ins-7 expression to control longevity. ( A) mRNA levels of lifespan-regulating ILPs in young (1 day old) and mid- aged (9 days old) wt, dcap-1 and neuronal dcap-1 overexpressing worms. ( B) Fluorescence intensity of ins-7p::gfp reporter in whole worms or head neurons of wt and dcap-1 animals. ( C–D) Total fluorescence intensity of ins-7p::gfp reporter in neurosecretion defective unc-31 orunc-13 mutants. ( E)" 1278 1730 W3021931547.pdf 5 3 separator 0.7089727 ¶ 1730 1732 W3021931547.pdf 5 4 caption 0.9765638 "ins-7 mRNA levels in 9 days old worms overexpressing dcap-1::gfp in neurons ( synEx293 ) or intestine ( synEx328 ). (F) Total fluorescence intensity of ins- 7p::gfp reporter in ins-7 mutants. ( G)ins-7 mature mRNA/pre-mRNA ratio in ins-7 and dcap-1;ins-7 animals that carry a neuronally expressed unc-119p:: ins-7 transgene. ( H) Lifespan of wt and neuronal dcap-1 overexpressing worms sensitized for neuronal RNAi during post-developmental ins-7 RNAi" 1732 2188 W3021931547.pdf 5 5 separator 0.86372006 ¶ 2188 2190 W3021931547.pdf 5 6 caption 0.9749989 knockdown. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Error bars indicate mean ±SD. Unpaired t-test ( A–G); Log-rank (Mantel-Cox) test ( F). 2190 2333 W3021931547.pdf 5 7 separator 0.9892206 ¶ 2333 2335 W3021931547.pdf 5 8 paratext 0.50974596 The online version of this article includes the following source data and figure supplement(s) for figure 3: 2335 2444 W3021931547.pdf 5 9 separator 0.98353755 ¶ 2444 2446 W3021931547.pdf 5 10 caption 0.8784877 Source data 1. Lifespan replicates of worms exposed to ins-7 RNAi at 20 ̊C. 2446 2521 W3021931547.pdf 5 11 separator 0.88696975 ¶ 2521 2523 W3021931547.pdf 5 12 table 0.48427156 Source data 2. Figure 2523 2545 W3021931547.pdf 5 13 text 0.4218987 3A, 2545 2549 W3021931547.pdf 5 14 table 0.42440736 E and G 2549 2557 W3021931547.pdf 5 15 caption 0.3825242 and 2557 2561 W3021931547.pdf 5 16 table 0.37189347 Figure 2561 2567 W3021931547.pdf 5 17 text 0.397866 3 2567 2569 W3021931547.pdf 5 18 table 0.38528204 — 2569 2570 W3021931547.pdf 5 19 caption 0.35970804 figure supplement 2570 2587 W3021931547.pdf 5 20 table 0.46739468 6 . 2587 2591 W3021931547.pdf 5 21 separator 0.48072875 ¶ 2591 2593 W3021931547.pdf 5 22 table 0.54853266 Source data 3. Figure 2593 2615 W3021931547.pdf 5 23 text 0.42136353 3 2615 2617 W3021931547.pdf 5 24 table 0.5191737 B, C, D and F andFigure 3— 2617 2643 W3021931547.pdf 5 25 caption 0.35702482 figure 2643 2649 W3021931547.pdf 5 26 table 0.51782614 supplement 2A . 2649 2665 W3021931547.pdf 5 27 separator 0.990337 ¶ 2665 2667 W3021931547.pdf 5 28 caption 0.5686576 Figure supplement 1. 2667 2688 W3021931547.pdf 5 29 text 0.5498449 Transcriptional 2688 2704 W3021931547.pdf 5 30 caption 0.55193055 activity of in 2704 2719 W3021931547.pdf 5 31 text 0.45090672 s-7 2719 2722 W3021931547.pdf 5 32 caption 0.6521541 promoter is significantly increased in dcap-1 mutants. 2722 2777 W3021931547.pdf 5 33 separator 0.9042378 ¶ 2777 2779 W3021931547.pdf 5 34 text 0.6053243 Figure supplement 2. Mutation of dcap-1 does not affect the expression of a ges-1p::gfp transgene. 2779 2878 W3021931547.pdf 5 35 separator 0.8645686 ¶ 2878 2880 W3021931547.pdf 5 36 text 0.76464856 Figure supplement 3. Transcriptional activity of ins-7 promoter is not increased in dcap-1 mutants when unc-31 is missing. 2880 3003 W3021931547.pdf 5 37 separator 0.89329016 ¶ 3003 3005 W3021931547.pdf 5 38 text 0.58221287 Figure supplement 4. Transcriptional activity of ins-7 3005 3060 W3021931547.pdf 5 39 caption 0.47695294 promo 3060 3066 W3021931547.pdf 5 40 text 0.50094914 ter 3066 3069 W3021931547.pdf 5 41 caption 0.5273085 in un 3069 3075 W3021931547.pdf 5 42 text 0.6053515 c-31 3075 3079 W3021931547.pdf 5 43 caption 0.6410424 mutants is further induced upon daf-16 knockdown. 3079 3129 W3021931547.pdf 5 44 separator 0.9163947 ¶ 3129 3131 W3021931547.pdf 5 45 caption 0.6922825 Figure supplement 5. Transcriptional activity of ins-7 promoter is significantly increased in dcap-1 mutants independently of unc-13 . 3131 3266 W3021931547.pdf 5 46 separator 0.90748644 ¶ 3266 3268 W3021931547.pdf 5 47 caption 0.6907619 Figure supplement 6. Transcriptional activity of ins-7 promoter is not increased in dcap-1 mutants when ins-7 gene product is missing. 3268 3403 W3021931547.pdf 5 48 separator 0.9107561 ¶ 3403 3405 W3021931547.pdf 5 49 caption 0.93313664 Figure supplement 7. The ratio of eft-3 mature mRNA/pre-mRNA is not affected by dcap-1 mutation. 3405 3502 W3021931547.pdf 5 50 separator 0.9882591 ¶ 3502 3504 W3021931547.pdf 5 51 paratext 0.97543526 Borbolis et al. eLife 2020;9:e53757. DOI: https://doi.org/10.7554/eLife.53757 6 of 23Research article Genetics and Genomics 3504 3628 W3021931547.pdf 5 0 text 0.92199886 "2)If the current item has P < h, then the algorithm trig- gers a decision round, assessing a posterior probabil - ity kP that takes the evidence of the subsequent item of the list into account." 0 200 W4391463580.pdf 3 1 separator 0.9954598 ¶ 201 203 W4391463580.pdf 3 2 text 0.6440704 2.1 If the current item has kP ≥ h 203 238 W4391463580.pdf 3 3 title 0.71238023 ", then the posterior probability is accepted as the new prior. Go back " 238 313 W4391463580.pdf 3 4 text 0.5037367 ¶ 313 314 W4391463580.pdf 3 5 title 0.73353606 to step 1. 314 325 W4391463580.pdf 3 6 separator 0.9722558 ¶ 325 327 W4391463580.pdf 3 7 title 0.5568747 2.2 If the 327 338 W4391463580.pdf 3 8 text 0.50441724 current 338 346 W4391463580.pdf 3 9 title 0.6036464 346 347 W4391463580.pdf 3 10 text 0.54511666 item has kP < h 347 362 W4391463580.pdf 3 11 title 0.5350279 , 362 363 W4391463580.pdf 3 12 text 0.46628365 then 363 368 W4391463580.pdf 3 13 separator 0.8700013 ¶ 369 371 W4391463580.pdf 3 14 text 0.9824154 "2.2.1 If more subsequent items are available, go back to step 2.1 and repeat the process by using the posterior probability as the new prior and incorporating the new evidence. 2.2.2 If no more subsequent items are available, then the OG root is found at the ancestral node that does not include the common ancestor to the current and all subsequent items of the list." 371 763 W4391463580.pdf 3 15 separator 0.9839072 ¶ 763 765 W4391463580.pdf 3 16 text 0.99759656 "The bridge algorithm uses the posterior probabilities as weights, aggregating the predictions into a weighted average ensemble model. Given the current item m and the subsequent items of the ordered list of branches (i = m, ..., n), the posterior probability kP is given by:" 765 1050 W4391463580.pdf 3 17 separator 0.95492315 ¶ 1050 1052 W4391463580.pdf 3 18 math 0.9413538 "kP(O†B, data) =Xn i=mP(O†B i,data)·P(B i†data) (2)" 1052 1105 W4391463580.pdf 3 19 separator 0.59436655 ¶ 1106 1108 W4391463580.pdf 3 20 text 0.98617333 "where P(O|B i, data) is the probability of occurrence of an ortholog O given a branch Bi and the observed data. This probability is calculated within each branch separately (see Equation (1)). P(B i|data) is the posterior probability of branch Bi given the observed data, which is calculated during the decision rounds for the branch model selection." 1108 1471 W4391463580.pdf 3 21 separator 0.97656345 ¶ 1471 1473 W4391463580.pdf 3 22 text 0.9988592 "Whenever a posterior probability is accepted as the new prior (see step 2.1), a “bridge” is included in the evolution - ary model, thus reconciling the phyletic pattern up to that point of the loop. This acceptance step effectively bridges the current item of the loop with the next one, allowing the algorithm to explore additional evidence that might root the ortholog at more ancestral nodes of the tree." 1473 1898 W4391463580.pdf 3 23 separator 0.9958998 ¶ 1898 1900 W4391463580.pdf 3 24 title 0.9921182 Uncertainty of Root Placement 1900 1930 W4391463580.pdf 3 25 separator 0.9959755 ¶ 1930 1932 W4391463580.pdf 3 26 text 0.99903464 "After placing the OG root at the given ancestral node of the tree, then the bridge algorithm proceeds to estimate uncer - tainty regarding the root placement, which represents the optimal point that splits the probability distribution into 2 branch ensembles: one enriched with the queried OG (i.e. all branches supporting a vertical heritage pattern) and an- other one with low evidence in favor of the OG's presence (say branch ensembles M and N, respectively). Given M (i = 1, ..., m) and N (i = m + 1, ..., n), a consistency score D is calculated by aggregating these 2 ensembles as follows:" 1932 2549 W4391463580.pdf 3 27 separator 0.98324907 ¶ 2549 2551 W4391463580.pdf 3 28 math 0.94470584 "M=Xm i=1P(O†B i,data)·P(B i†data) (3) N=Xn i=m+1P(O†B i,data)·P(B i†data) (4) D=M−N (5)" 2551 2649 W4391463580.pdf 3 29 separator 0.52200484 ¶ 2650 2652 W4391463580.pdf 3 30 math 0.53830427 "A B C" 2652 2660 W4391463580.pdf 3 31 separator 0.9952816 ¶ 2660 2662 W4391463580.pdf 3 32 caption 0.91169053 Fig. 3. The performance of the bridge algorithm to predict roots for 300 simulated random ROGs. a) An uncertainty of root placement 2662 2794 W4391463580.pdf 3 33 text 0.94298184 ". Each data point displays a consistency score (D) along with the associated P-value (on a −log10 scale) calculated for a simulated ROG. A low P-value (green circles) indicates that the predicted root is supported by a phyletic pattern in the data. Each ROG was simulated using default parameters of the simulateRogs() function available in the GeneBridge package. b) Three confusion matrices showing ROG's roots predicted by the bridge algorithm for varying penalty factors. The ROG simulation generated reference roots by modeling ideal vertical heritage patterns. These patterns were then subjected to random gain and loss events at fixed probability levels. The simulation used a random phylogenetic tree with 7 possible roots, referred to as classes. c) Performance plots depicting balanced " 2794 3608 W4391463580.pdf 3 34 caption 0.5929322 accura 3608 3614 W4391463580.pdf 3 35 text 0.53954405 cy across the different 3614 3637 W4391463580.pdf 3 36 caption 0.59101576 root classes 3637 3650 W4391463580.pdf 3 37 text 0.65984863 , using a fixed penalty 3650 3673 W4391463580.pdf 3 38 caption 0.56099766 factor in 3673 3683 W4391463580.pdf 3 39 text 0.5915356 the bridge ¶ 3683 3697 W4391463580.pdf 3 40 caption 0.49988332 3697 3698 W4391463580.pdf 3 41 text 0.53051275 algorithm, 3698 3709 W4391463580.pdf 3 42 caption 0.5172723 while 3709 3714 W4391463580.pdf 3 43 text 0.6040133 varying gain and 3714 3731 W4391463580.pdf 3 44 caption 0.53051585 loss probabil 3731 3745 W4391463580.pdf 3 45 text 0.53514874 ities 3745 3750 W4391463580.pdf 3 46 caption 0.6299551 in 3750 3753 W4391463580.pdf 3 47 text 0.6240129 the ROG 3753 3761 W4391463580.pdf 3 48 caption 0.5271102 simulation 3761 3772 W4391463580.pdf 3 49 text 0.59267986 . A detailed reproduction of the simulation is provided in the vignette 3772 3845 W4391463580.pdf 3 50 separator 0.45192313 ¶ 3845 3846 W4391463580.pdf 3 51 text 0.5740036 of the GeneBridge package. 3846 3873 W4391463580.pdf 3 52 paratext 0.9301663 Campos et al.·https://doi.org/10 .1093/molbev/ms ae019 TGKDownloaded from https://academic.oup.com/mbe/article/41/2/msae019/7596672 by guest on 18 May 2024 3873 4028 W4391463580.pdf 3 53 separator 0.99529207 ¶ 4028 4030 W4391463580.pdf 3 0 paratext 0.5211301 References 0 10 W2972676464.pdf 24 1 separator 0.9932517 ¶ 10 12 W2972676464.pdf 24 2 bibliography 0.9976725 "1. B. D. Bue et al., “Leveraging in-scene spectra for vegetation species discrimination with MESMA-MDA, ”ISPRS J. Photogramm. Remote Sens. 108,3 3–48 (2015)." 12 172 W2972676464.pdf 24 3 separator 0.88143337 ¶ 172 174 W2972676464.pdf 24 4 bibliography 0.997624 "2. K. L. 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Kenzer, “The decline of fieldwork in human geography, ”Prof. Geogr. 41(3), 294 –303 (1989).Chehdi and Cariou: Learning or assessment of classification algorithms relying. . ." 3978 4185 W2972676464.pdf 24 49 separator 0.9706224 ¶ 4185 4187 W2972676464.pdf 24 50 paratext 0.9609274 Journal of Applied Remote Sensing 034522-24 Jul –Sep 2019 Vol. 13(3) 4187 4257 W2972676464.pdf 24 0 paratext 0.97674525 A Spin Glass Model for Reconstructing... 803 0 44 W3105470691.pdf 14 1 separator 0.99434304 ¶ 44 46 W3105470691.pdf 14 2 text 0.99162084 "when performing the replica limit n→0, using explicit forms Eqs. ( 38)–(39), remembering qd=R2−t2and finally understanding by x(q)only its non-trivial part in the interval q0,qk we arrive to the following" 46 254 W3105470691.pdf 14 3 separator 0.97005785 ¶ 254 256 W3105470691.pdf 14 4 text 0.4151096 Pro 256 260 W3105470691.pdf 14 5 title 0.5042774 position 260 268 W3105470691.pdf 14 6 text 0.92618006 "2.1 Given the values of real parameters R >0andμ> 1, consider the func- tional" 268 349 W3105470691.pdf 14 7 separator 0.8816706 ¶ 349 351 W3105470691.pdf 14 8 math 0.94915074 "φ[x(q);q0,qk,t]=μln⎩parenleftbig 1+β⎩bracketleftbig /Phi1(R2)−/Phi1(qk+t2)⎩bracketrightbig⎩parenrightbig −ln(R2−t2−qk) +μβ⎩bracketleftbig σ2+/Phi1(R2)−2/Phi1(Rt)+/Phi1(q0+t2)⎩bracketrightbig 1+β⎩bracketleftbig /Phi1(R2)−/Phi1(qk+t2)⎩bracketrightbig +β⎩integraltextqk q0x(u)/Phi1/prime(u+t2)du −q0 R2−t2−qk+⎩integraltextqk q0x(u)du +μβ⎩integraldisplayqk q0/Phi1/prime(q+t2)dq 1+β⎩bracketleftbig /Phi1(R2)−/Phi1(qk+t2)⎩bracketrightbig +β⎩integraltextqk qx(u)/Phi1/prime(u+t2)du −⎩integraldisplayqk q0dq R2−t2−qk+⎩integraltextqk qx(u)du, (47)" 351 935 W3105470691.pdf 14 9 separator 0.52958035 ¶ 935 937 W3105470691.pdf 14 10 text 0.90248156 "which depends on the parameters −R≤t≤R, and 0≤q0≤qk2000μm 2 were scanned to obtain the averaged dislocation density." 3821 4205 W3133893801.pdf 1 13 separator 0.90162945 ¶ 4205 4207 W3133893801.pdf 1 14 text 0.9987217 "Transmittance (T ) and re flectance (R ) were characterized in a Lambda 950 Spectrophotometer from PerkinElmer in the wave- length range from 280 to 1200 nm." 4207 4368 W3133893801.pdf 1 15 title 0.8545997 "Table 1. Structural properties of two generations of GaInP/GaAs/Si triple- junction solar cells. Gen II has been presented in a previous publication.[6]" 4368 4522 W3133893801.pdf 1 16 separator 0.9903442 ¶ 4522 4524 W3133893801.pdf 1 17 table 0.98827404 "Gen II Gen IV Si bottom cell Base resistivity 2Ωcm 20Ωcm Miscut 2/C14toward (111) 6/C14toward (111) Surface finish CMP Stock Polish Step graded buffer GaAs yP1/C0y AlxGa1/C0xAsyP1/C0y Protection layer – 5 nm GaAs GaAs middle cell 760 nm 790 nm GaInP top cell 390 nm 400 nm ARC Ta 2O5/MgF 79 nm/110 nm 65 nm/110 nm" 4524 4855 W3133893801.pdf 1 18 separator 0.98568213 ¶ 4855 4857 W3133893801.pdf 1 19 caption 0.99668306 Figure 1. AFM scans (2 /C22μm2) of a) a CMP-treated Si surface and b) a Si surface prepared by a low-cost “stock polish ”process developed by Topsil. 4857 5007 W3133893801.pdf 1 20 separator 0.86431485 ¶ 5007 5009 W3133893801.pdf 1 21 caption 0.9500968 The latter one is used for the solar cell presented within this work. 5009 5079 W3133893801.pdf 1 22 separator 0.85641205 ¶ 5079 5081 W3133893801.pdf 1 23 contact 0.30646327 www.advancedscience 5081 5101 W3133893801.pdf 1 24 paratext 0.32144213 news 5101 5105 W3133893801.pdf 1 25 contact 0.3989216 . 5105 5106 W3133893801.pdf 1 26 paratext 0.4628447 "com www." 5106 5117 W3133893801.pdf 1 27 contact 0.39107203 solar- 5117 5123 W3133893801.pdf 1 28 paratext 0.45264068 rrl.com 5123 5130 W3133893801.pdf 1 29 separator 0.9305873 ¶ 5130 5132 W3133893801.pdf 1 30 paratext 0.9809478 Sol. RRL 2021, 5, 2000763 2000763 (2 of 7) © 2021 The Authors. 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[CrossRef] [PubMed]" 3195 3560 W2963448028.pdf 10 25 separator 0.96297204 ¶ 3560 3562 W2963448028.pdf 10 26 bibliography 0.9972227 "30. Rhode, P .R.; Egan, J.O.; Xu, W.; Hong, H.; Webb, G.M.; Chen, X.; Liu, B.; Zhu, X.; Wen, J.; You, L.; et al. Comparison of the Superagonist Complex, ALT-803, to IL15 as Cancer Immunotherapeutics in Animal Models. Cancer Immunol. Res. 2016 ,4, 49–60. [CrossRef] [PubMed]" 3562 3840 W2963448028.pdf 10 27 separator 0.9468498 ¶ 3840 3842 W2963448028.pdf 10 28 bibliography 0.99800354 "31. Romee, R.; Cooley, S.; Berrien-Elliott, M.M.; Westervelt, P .; Verneris, M.R.; Wagner, J.E.; Weisdorf, D.J.; Blazar, B.R.; Ustun, C.; DeFor, T.E.; et al. First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation. Blood 2018 ,131, 2515–2527. [CrossRef] [PubMed]" 3842 4172 W2963448028.pdf 10 29 separator 0.93002427 ¶ 4172 4174 W2963448028.pdf 10 30 bibliography 0.9979041 "32. Pasche, N.; Neri, D. Immunocytokines: A novel class of potent armed antibodies. Drug Discov. Today 2012 , 17, 583–590. [CrossRef] [PubMed]" 4174 4319 W2963448028.pdf 10 31 separator 0.9333066 ¶ 4319 4321 W2963448028.pdf 10 32 bibliography 0.9980069 "33. Vincent, M.; Bessard, A.; Cochonneau, D.; Teppaz, G.; Sole, V .; Maillasson, M.; Birkle, S.; Garrigue-Antar, L.; Quemener, A.; Jacques, Y. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int. J. Cancer 2013 ,133, 757–765. [CrossRef] [PubMed]" 4321 4634 W2963448028.pdf 10 33 separator 0.9449899 ¶ 4634 4636 W2963448028.pdf 10 34 bibliography 0.9979964 "34. Jochems, C.; Tritsch, S.R.; Knudson, K.M.; Gameiro, S.R.; Rumfield, C.S.; Pellom, S.T.; Morillon, Y.M.; Newman, R.; Marcus, W.; Szeto, C.; et al. The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex. Oncoimmunology 2019 ,8, e1532764." 4636 4947 W2963448028.pdf 10 35 separator 0.7488538 ¶ 4947 4949 W2963448028.pdf 10 36 bibliography 0.9972127 [CrossRef] [PubMed] 4949 4969 W2963448028.pdf 10 0 paratext 0.95607734 55 0 2 W4321390770.pdf 61 1 separator 0.9916154 ¶ 3 5 W4321390770.pdf 61 2 title 0.8919513 Filmin Künyesi: 6 22 W4321390770.pdf 61 3 separator 0.85700214 ¶ 24 26 W4321390770.pdf 61 4 title 0.5204455 Paisà 26 32 W4321390770.pdf 61 5 table 0.3726293 ( 33 35 W4321390770.pdf 61 6 text 0.434977 Türkçe 35 41 W4321390770.pdf 61 7 table 0.37895867 : 41 42 W4321390770.pdf 61 8 text 0.43074575 Hem 42 46 W4321390770.pdf 61 9 title 0.4094947 şe 46 48 W4321390770.pdf 61 10 text 0.30978686 hri 48 51 W4321390770.pdf 61 11 table 0.46316034 ) 51 52 W4321390770.pdf 61 12 separator 0.7424909 ¶ 54 56 W4321390770.pdf 61 13 bibliography 0.43523434 1946 56 61 W4321390770.pdf 61 14 table 0.44042853 , 61 63 W4321390770.pdf 61 15 bibliography 0.5438509 Roberto Rossellini 63 81 W4321390770.pdf 61 16 separator 0.5577252 ¶ 83 85 W4321390770.pdf 61 17 bibliography 0.68995625 "IMDB ID: https://www.imdb.com/title/tt0038823/?ref_=nv_sr_srsg_0 (Görsel Kaynağı: https://www.rottentomatoes.com/m/paisan )" 85 213 W4321390770.pdf 61 18 separator 0.95393014 "¶ ¶" 214 225 W4321390770.pdf 61 19 table 0.6462682 "Filmin Künyesi: Stromboli" 225 255 W4321390770.pdf 61 20 separator 0.4731458 ¶ 257 259 W4321390770.pdf 61 21 bibliography 0.46571708 1950, 259 265 W4321390770.pdf 61 22 table 0.4527976 265 266 W4321390770.pdf 61 23 bibliography 0.6009665 Roberto Rossellini 266 284 W4321390770.pdf 61 24 separator 0.49775684 ¶ 286 288 W4321390770.pdf 61 25 bibliography 0.7491952 "IMDB ID: https://www.imdb.com/title/tt0041931/?ref_=nv_sr_srsg_1 (Görsel Kaynağı: https://www.rottentomatoes.com/m/stromboli)" 288 418 W4321390770.pdf 61 26 separator 0.9598977 "¶ ¶" 419 430 W4321390770.pdf 61 27 table 0.6338931 Filmin Künyesi: 430 446 W4321390770.pdf 61 28 separator 0.51349235 ¶ 448 450 W4321390770.pdf 61 29 table 0.58227545 Umberto D. 450 461 W4321390770.pdf 61 30 separator 0.7120283 ¶ 463 465 W4321390770.pdf 61 31 bibliography 0.69083303 1952, Vittorio De Sica 465 488 W4321390770.pdf 61 32 separator 0.5342101 ¶ 490 492 W4321390770.pdf 61 33 bibliography 0.80810195 "IMDB ID: https://www.imdb.com/title/tt0045274/?ref_=nv_sr_srsg_0" 492 561 W4321390770.pdf 61 34 separator 0.5036801 ¶ ¶ 561 567 W4321390770.pdf 61 35 bibliography 0.8332136 "(Görsel Kaynağı: https://www.amazon.co.uk/Umberto-D- Carlo - Battisti/dp/B01HN80IK8 )" 567 655 W4321390770.pdf 61 36 separator 0.9904978 ¶ ¶ 656 663 W4321390770.pdf 61 0 paratext 0.95747435 "Journal of Bioscience and Applied Research, 2021, Vol. 7, No. 3, P.116 -129 pISSN: 2356 -9174, eISSN: 2356 -9182 116 ¶" 0 148 W3207995493.pdf 0 1 separator 0.58844304 ¶ 150 152 W3207995493.pdf 0 2 paratext 0.94737554 "Received: July 2 6, 2021. Accepted: September 1 8, 2021. Published: September 2 9, 2021 ¶ BioBacta Journal of Bioscience and Applied Research www.jbaar.org" 152 332 W3207995493.pdf 0 3 separator 0.6145223 335 336 W3207995493.pdf 0 4 paratext 0.4944969 ¶ 336 337 W3207995493.pdf 0 5 separator 0.9823948 ¶ 339 341 W3207995493.pdf 0 6 title 0.9741347 "T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE) : Correlation with Clinical Manifestation" 341 471 W3207995493.pdf 0 7 separator 0.991027 ¶ ¶ 473 479 W3207995493.pdf 0 8 contact 0.64352393 Abeer M. El -Maghraby1 479 503 W3207995493.pdf 0 9 bibliography 0.47705686 , 503 504 W3207995493.pdf 0 10 contact 0.69471735 Yasser B 504 513 W3207995493.pdf 0 11 bibliography 0.5535624 . 513 514 W3207995493.pdf 0 12 contact 0.58098364 M 514 515 W3207995493.pdf 0 13 bibliography 0.5757465 . 515 516 W3207995493.pdf 0 14 contact 0.6285732 Ali2 516 521 W3207995493.pdf 0 15 bibliography 0.57559025 , 521 522 W3207995493.pdf 0 16 contact 0.70536757 Eman A 522 529 W3207995493.pdf 0 17 bibliography 0.56118405 . El 529 533 W3207995493.pdf 0 18 contact 0.49021035 533 534 W3207995493.pdf 0 19 bibliography 0.4949925 - 534 535 W3207995493.pdf 0 20 contact 0.681861 maadawy2 535 543 W3207995493.pdf 0 21 bibliography 0.61450857 , 543 544 W3207995493.pdf 0 22 contact 0.6528887 Mohamed F 544 554 W3207995493.pdf 0 23 bibliography 0.6061801 . 554 555 W3207995493.pdf 0 24 contact 0.6838246 Elshal2 555 563 W3207995493.pdf 0 25 bibliography 0.54861253 , 563 564 W3207995493.pdf 0 26 contact 0.6791409 Iman H 564 571 W3207995493.pdf 0 27 bibliography 0.46414742 572 573 W3207995493.pdf 0 28 contact 0.6201589 ¶ Bassyouni 573 584 W3207995493.pdf 0 29 bibliography 0.555994 3, 584 586 W3207995493.pdf 0 30 contact 0.6382171 Islam M 586 594 W3207995493.pdf 0 31 bibliography 0.56802917 El - 594 599 W3207995493.pdf 0 32 contact 0.70911264 Garawani 599 607 W3207995493.pdf 0 33 bibliography 0.52663803 1, 607 609 W3207995493.pdf 0 34 contact 0.79736423 Roba M. Talaat2 609 625 W3207995493.pdf 0 35 separator 0.9330478 ¶ 626 628 W3207995493.pdf 0 36 contact 0.99461883 "1Zoology Department, Faculty of Science, Menoufia University, Shebin El -Kom 32511, Menoufia, Egypt; dr.garawani@science.menofia.edu.eg ; 2Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt. dr_abeer_elmaghraby@yahoo.com , eman.anwr@gebri.usc.edu.eg , yasser.ali@gebri.usc.edu.eg , mohamed.elshal@gebri.usc.edu.eg" 628 1031 W3207995493.pdf 0 37 separator 0.5392003 ¶ 1033 1035 W3207995493.pdf 0 38 contact 0.9846479 "3Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt. iman.bassyouni@kasralainy.edu.eg " 1035 1172 W3207995493.pdf 0 39 separator 0.508261 ¶ 1172 1173 W3207995493.pdf 0 40 contact 0.9935081 "Corresponding author: Dr. Roba M. Talaat. Prof. of Molecular Immunology, Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC), Egypt. Fax: +2 048 260 1266/68 Tel. +2 048 260 1264/65 E-mail address: roba.talaat@gebri.usc.edu.eg" 1173 1489 W3207995493.pdf 0 41 separator 0.99203193 ¶ 1491 1493 W3207995493.pdf 0 42 title 0.7057454 1493 1494 W3207995493.pdf 0 43 paratext 0.5136315 Running 1494 1501 W3207995493.pdf 0 44 title 0.9568855 Title: T-lymphocyte regulation in SLE patients 1501 1548 W3207995493.pdf 0 45 separator 0.666191 ¶ 1550 1552 W3207995493.pdf 0 46 paratext 0.90524226 DOI: 10.21608/jbaar.2021.198735 1552 1584 W3207995493.pdf 0 47 separator 0.98627865 ¶ 1586 1588 W3207995493.pdf 0 48 title 0.947805 Abstract 1588 1597 W3207995493.pdf 0 49 separator 0.9821608 ¶ 1599 1601 W3207995493.pdf 0 50 text 0.9944871 "AIM: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that has a multifactorial etiology. T- Lymphocytes are essential in SLE pathogenesis . It plays a crucial role in autoantibody production and the subsequent immune complex formation, which may induce or directly damage multiple organs. This study was carried out aiming to quantify certain T lymphocyte subsets (CD3+, CD4+, and CD8+) in SLE patients and to elucidate if there is a possible influence of disease activity scores and clinical manifestations . Patients and" 1601 2161 W3207995493.pdf 0 51 separator 0.7948923 ¶ 2162 2164 W3207995493.pdf 0 52 text 0.99632645 "Methods: This study included 100 SLE patients with various disease activity scores (SLEDAI) and 100 healthy age and sex -matched controls . The frequency of CD3+, CD4+, and CD8+ was assessed by flow cytometry. Results: A significant up -regulation in CD3+ (P<0.01), CD8+ (P<0. 001) coincides with a significant downregulation in CD4+cells (P<0.0 01) were detected in SLE patients compared to controls. A significant up -regulation in CD4+ (P<0.05) was demonstrated in active S LE patients compared with the inactive form of the disease. On the other hand, n o significant change was observed in the frequenc y of CD3+ and CD8+T cell sub sets between active and inactive patients. Arthritic patients have a significant reduction in CD3+ and CD4+ T cells while those with Vasculities significant ly reduce in CD4+, CD8+ compared with SLE patients without these manifestations." 2164 3063 W3207995493.pdf 0 53 separator 0.995435 ¶ 3066 3068 W3207995493.pdf 0 0 paratext 0.9893818 Vaccines 2021 ,9, 1236 2 of 15 0 30 W3208105146.pdf 1 1 separator 0.99300486 ¶ 30 32 W3208105146.pdf 1 2 text 0.9997202 "more attention in recent years based on its efficiency of inducing systemic and mucosal immune responses; including humoral and CTL responses in both mucosal and extra- mucosal tissues [ 5–13]. In HIV vaccine development, sublingual vaccination with an HIV subunit vaccine can induce strong mucosal immune responses evidenced by high levels of antibodies and CTLs detected in the mouse female genital tract [ 6]. By using adenoviral vector encoding HIV-Gag or HIV-envelope gp120 (Env), sublingual immunization can elicit both mucosal and systemic immunity against HIV [ 7,8]. These data indicate the sublingual immunization route is a promising route for mucosal vaccine development." 32 729 W3208105146.pdf 1 3 separator 0.96429944 ¶ 729 731 W3208105146.pdf 1 4 text 0.9997673 "Studies have found that antigen size and repetitive structure are critical factors for efficient antigen presentation to B cells, and that the particulate antigens such as virus-like particles (VLPs) are better antigens than soluble proteins [ 14,15]. VLPs have therefore shown dramatic effectiveness as candidate vaccines [ 14,16–18]. We have previously pro- duced a chimeric CD40L/SHIV VLPs (simian-human immunodeficiency virus-like parti- cles) using a baculovirus expression system which contains SIV Gag, HIV gp160 envelope (cleaved to gp41 and gp120), and CD40 ligand (CD40L) by taking advantage of existing knowledge about CD40/CD40L interactions between T cells and DCs which are critical for the induction and regulation of immune responses. We showed that chimeric CD40L/SHIV VLPs were able to induce enhanced immune responses in mice both by targeting HIV anti- gens to DCs and also by activating DCs for T cell activation. Enhanced mucosal humoral and cellular immune responses can be achieved by intranasal immunization in the mouse model by the chimeric CD40L/SHIV VLPs [ 19]. Therefore, the mucosal immunogenicity of particulate sized immunogen such as VLPs should be explored in sublingual immunization route." 731 1983 W3208105146.pdf 1 5 separator 0.9821806 ¶ 1983 1985 W3208105146.pdf 1 6 text 0.99971044 "In order to enhance the delivery of antigen to the oral-sub-mucosal and encounter DCs, we hypothesized that modified VLPs that specifically target the oral mucosal epithelium will facilitate antigen delivery and therefore enhance antigen presentation and the adaptive immune response. C1q is the first subcomponent of the C1 complex involved in the classical pathway of complement activation and was recently reported to be the ligand of CD91, a multifunctional scavenger and signaling receptor [ 20]. Interestingly, CD91 is reported to be highly expressed by human salivary gland epithelial cells, which makes it a potential specific target for an oral mucosal vaccine [21]." 1985 2671 W3208105146.pdf 1 7 separator 0.98042953 ¶ 2671 2673 W3208105146.pdf 1 8 text 0.9997081 "The sub-mucosal layer of the sublingual mucosa contains a dense network of DCs, and DCs rely on a number of specialized receptors to facilitate the uptake and intracellular accumulation of antigens. Studies have demonstrated that the targeted delivery of antigens in vivo to CD91 induces enhanced activation of the adaptive immune system. It was further found that a subset of CD11c+lineage-negative (lin" 2673 3086 W3208105146.pdf 1 0 title 0.98059076 Evaluation Method 0 17 W2905452096.pdf 4 1 separator 0.97291404 ¶ 17 19 W2905452096.pdf 4 2 title 0.98903704 Facebook Metrics 19 36 W2905452096.pdf 4 3 separator 0.97874653 ¶ 36 38 W2905452096.pdf 4 4 text 0.9975057 "Facebook metrics were collected through the Facebook Ads Manager , including reach (ie, the number of users who saw the adverts in their News Feed at least once), link clicks (ie, the number of users who click ed on the advertisement), cost per click (ie, campaign cost divided by the number of link clicks), and relevance (a score out of 10 generated by Facebook, which estimates how well the target audience is responding to the advertisement). Higher relevance scores indicate positi ve user engagement (eg, link clicks), whereas lower scores indicate negative interactions (eg, hiding or reporting an advertisement) [28]." 38 684 W2905452096.pdf 4 5 separator 0.9960393 ¶ 684 686 W2905452096.pdf 4 6 title 0.99249226 Recruitment Rates and Costs 686 714 W2905452096.pdf 4 7 separator 0.99163866 ¶ 714 716 W2905452096.pdf 4 8 text 0.9971221 "Recruitment rates and costs were calculated following the Checklist for Reporting Results of Internet E-Surv eys (CHERRIES) [29]. The CHERRIES frame work is designed to guide the quality reporting of online surveys in the same way as the Consolidated Standards of Reporting Trials statement guides the reporting of randomized controlled trials. As such, we report several metrics that speak to the quality and completeness of the data and of the overall feasibility of Facebook recruitment (that is, was a useable sample and dataset obtained?). These include the following: view rate: the ratio of Facebook users who click ed on the advertisement and visited the survey landing page divided by users who saw the advertisement (click to reach ratio); participation rate: the ratio of those who consented to participate divided by the number of visitors to the survey landing page (consent to click ratio); and completion rate: the ratio of the number of people who completed the survey divided by those who consented to participate (completion to consent ratio). Cost per consent and cost per completer for each campaign were also derived. It was not possible to calculate the view rates or response rates for our free recruitment strate gies." 716 1999 W2905452096.pdf 4 9 separator 0.9953004 ¶ 1999 2001 W2905452096.pdf 4 10 title 0.9927432 Determining Sample Representativ eness 2001 2040 W2905452096.pdf 4 11 separator 0.9917875 ¶ 2040 2042 W2905452096.pdf 4 12 text 0.99954456 "Comparison data were drawn from the Longitudinal Study of Australian Children (LSA C), Kinder garten (K) cohort (child age: 4-5 years at recruitment in 2004). Full sample details, design, and field methods are published elsewhere [30]. Briefly , LSAC emplo yed a 2-stage cluster sampling design using Australian postcodes and Australia’ s universal health insurance database (Medicare Australia) to recruit parents through a mailout. The LSAC sample is considered broadly representati ve of all Australian children and their parents. Data are collected biennially (since 2004) via a face-to-f ace intervie w with parents and a parent-report questionnaire [31,32]. Data from emplo yed parents were compared with this study’ s sample on baseline demographic characteristics and primary outcome measures at 3 waves: wave 1 (child age: 4-5 years), wave 4 (child age: 10-11 years), and wave 6 (child age: 14-15 years)." 2042 2984 W2905452096.pdf 4 13 separator 0.963853 ¶ 2984 2986 W2905452096.pdf 4 14 text 0.9995438 "The demographic characteristics used for comparison were marital status (married or de facto; single); country of birth (born outside Australia; born in Australia); education (with or without tertiary qualif ication); and neighborhood disadvanta ge, assessed using the Socio-Economic Index of Areas (SEIF A)Disadv antage score [33]. Postcodes provided by the participants were matched with the corresponding SEIF A score (Australian mean 1000). To assess for self-selection bias, we also compared participants on the 2 main survey measures: work-f amily conflict and psychological distress. Work-family conflict was measured using 4 items on a 5-point scale, from 1=“strongly disagree” to 5=“strongly agree”, adapted from Marshall and Barnett [34] and used widely in Australian research (eg, [35,36]). Scores across the 4 items were averaged, with higher scores indicating greater work-f amily conflict (alpha=.67). Psychological distress was assessed using the K6 [37] on a 5-point scale, from 1=“none of the time” to 5=“all of the time”. Responses were summed (range 6-30), with higher scores indicating greater psychological distress (alpha=.87)." 2986 4170 W2905452096.pdf 4 15 separator 0.99586904 ¶ 4170 4172 W2905452096.pdf 4 16 title 0.9925572 Statistical Analyses 4172 4193 W2905452096.pdf 4 17 separator 0.9953287 ¶ 4193 4195 W2905452096.pdf 4 18 text 0.9996261 "To determine Facebook recruitment rates and costs (Aim 1), survey data were exported from Qualtrics into StataSE14 (StataCorp) [38] and the number of consenting participants and completed surveys were summarized by the recruitment source (identif ied by the unique survey URLs). Facebook campaign costs were then summarized by the number of participants who provided consent (cost per consent) and the number of participants who completed the survey (ie, reached the end of the survey and click ed submit ; cost per completer). To assess sample representati veness (Aim 2), baseline (T1) demographic characteristics were compared with LSAC waves 1, 4, and 6." 4195 4874 W2905452096.pdf 4 19 separator 0.9617213 ¶ 4874 4876 W2905452096.pdf 4 20 text 0.99962467 "Only emplo yed parents from the LSAC sample were used, to provide a meaningful comparison. Independent sample t-tests were used to compare continuous variables (ie, work-f amily conflict, psychological distress, neighborhood disadv antage), and chi-square tests were used to compare categorical variables (ie, educational attainment, marital status, country of birth). To assess participant retention (Aim 3), the number of participants who completed the follow-up survey (ie, reached the end of the survey and click ed submit ) were compared with those who consented to be recontacted and with those who consented to the initial study . Demographic characteristics of T1 and T2 participants were compared using independent samples t-tests and chi-square tests, as appropriate." 4876 5678 W2905452096.pdf 4 21 separator 0.99633133 ¶ 5678 5680 W2905452096.pdf 4 22 title 0.98805386 Results 5680 5688 W2905452096.pdf 4 23 separator 0.8963032 ¶ 5688 5690 W2905452096.pdf 4 24 title 0.98752904 Survey Recruitment (T1) 5690 5714 W2905452096.pdf 4 25 separator 0.99219996 ¶ 5714 5716 W2905452096.pdf 4 26 text 0.999129 "After a 15-week recruitment period, there were a total of 6653 clicks on the survey link, resulting in 5378 eligible participants consenting and commencing the T1 survey. Of these 5378, 4665 (86.74%) participants completed the survey (ie, pressed submit at the end of the survey) and a further 532 (9.89%) participants provided partial data (ie, exited before pressing submit ); however, 181 (3.37%) participants provided consent but did not answer any questions. The proportion of consenting participants who provided complete, partial, or no data did not differ for the paid and free methods. Of the 4665 participants who provided complete data, 3440 (73.74%) were recruited through the 20 paid Facebook advertising campaigns, 79 (1.69%) through other paid online advertising, 782 (16.76%) through free Facebook advertising, and 364 (7.80%) through" 5716 6593 W2905452096.pdf 4 27 separator 0.75929123 ¶ 6593 6595 W2905452096.pdf 4 28 paratext 0.9693535 "J Med Internet Res 2019 | vol. 21 | iss. 3 | e11206 | p. 5 https://www .jmir.org/2019/3/e11206/ (page number not for citation purposes)Bennetts et al JOURN AL OF MEDICAL INTERNET RESEARCH XSL•FO" 6595 6794 W2905452096.pdf 4 29 separator 0.4510225 6794 6795 W2905452096.pdf 4 30 paratext 0.69040155 ¶ RenderX 6795 6804 W2905452096.pdf 4 0 paratext 0.9862975 www.nature.com/scientificreports/3 0 34 W2759608560.pdf 2 1 separator 0.74876386 ¶ 34 36 W2759608560.pdf 2 2 paratext 0.96160406 SCIentIfIC REPORTS | (2018) 8:10651 | DOI:10.1038/s41598-018-28999-2∑ 36 110 W2759608560.pdf 2 3 math 0.74823517 "∑ τ =− −− . It Wt Eu tt () ()() exp[ () /] (4) siiis synr ev syn" 110 178 W2759608560.pdf 2 4 separator 0.98964244 ¶ 178 180 W2759608560.pdf 2 5 text 0.9932792 The temporal dependence of the synaptic weights accounts for the STP mechanism we discuss later. 180 277 W2759608560.pdf 2 6 separator 0.95248365 ¶ 277 279 W2759608560.pdf 2 7 text 0.9743668 "Each neuron receives both functional synaptic input from other neurons within the network and diffuse back- ground input from external neurons that can be modeled as Poisson spike trains. The latter causes the neuron to fire stochastically. Since, at the level of spikes, the output of a neuron can be considered binary, we associate a binary random variable z k to each neuron. As a neuron never fires within the refractory period, it is natural to set zk = 1 for t tt[, )ks ks refτ ∈+ and 0 otherwise (Fig. 1b)." 279 806 W2759608560.pdf 2 8 separator 0.97531974 ¶ 806 808 W2759608560.pdf 2 9 text 0.98414296 "For constant functional synaptic input as defined above, the mean firing rate of such a neuron is proportional to its activation function p (zk = 1). By applying strong background input, we lift neurons into a high-conductance state (HCS)29, which molds their activation function into an approximately logistic shape30: p" 808 1138 W2759608560.pdf 2 10 math 0.5566491 z 1138 1139 W2759608560.pdf 2 11 text 0.58956254 1139 1140 W2759608560.pdf 2 12 math 0.7262505 u (1 )( ), (5) kkfσα β =≈ − 1140 1167 W2759608560.pdf 2 13 text 0.92126495 ¶ with scaling parameters α and β, where ukf represents the functional, i.e., background-free, membrane potential. 1167 1282 W2759608560.pdf 2 14 separator 0.9176039 ¶ 1283 1285 W2759608560.pdf 2 15 text 0.9979063 "Similarly to Gibbs sampling, the functional membrane potential thereby fulfills the local computability condition (equation 2), which is a sufficient computational prerequisite for sampling in neural networks 23,31. The scaling parameters can be derived analytically and allow a direct translation of the BM parameters W and b to the corre- sponding parameters in the biological domain (Methods, Sec. 1)." 1285 1698 W2759608560.pdf 2 16 separator 0.9853885 ¶ 1698 1700 W2759608560.pdf 2 17 text 0.99831116 "Training. To speed up training, we used RBMs with binary units. As a learning algorithm, we used the coupled adaptive simulated tempering (CAST) method16, which is a version of the wake-sleep algorithm. In CAST, two instances of the RBM are simulated in parallel, with one of them staying at a constant inverse temperature β = 1 for parameter update using persistent contrastive divergence32 (slow chain) and the other one using adaptive simulated tempering (AST)16 for mixing (fast chain). The states of the two RBMs are swapped constantly to help the slow chain jump out of local minima during parameter updating. In AST, states z(t+1) are updated by Gibbs sampling from β|pz()Tt(). After each state update, the temperature is itself updated by an adaptive rule that ensures the algorithm spends a roughly equal amount of time at each value βT. Details of the AST algorithm are described in Table 1. The training hyperparameters for different experiments can be found in Methods Sec. 2." 1700 2715 W2759608560.pdf 2 18 separator 0.98437107 ¶ 2715 2717 W2759608560.pdf 2 19 text 0.9943797 "The trained RBM parameters are then mapped to the spiking-network domain as described below28 (see Methods Sec. 1 for more details):" 2717 2853 W2759608560.pdf 2 20 separator 0.9829886 ¶ 2853 2855 W2759608560.pdf 2 21 math 0.9087713 "αμ ττ =− − −− −   τ ττ τ−− ()W CwE ee1 1(1 )1 , (6)kjkj kj mrev syn1 eff syn effsyn eff " 2855 2996 W2759608560.pdf 2 22 separator 0.42490295 ¶ 2996 2997 W2759608560.pdf 2 23 text 0.7546187 "where Wkj denotes the peak synaptic conductance (see equation 4), Cm the membrane capacitance, wkj the abstract Boltzmann weight, Ekjrev the corresponding reversal potential, μ the mean free membrane potential, τsyn the syn- aptic time constant and τeff = Cm/〈gtot〉 the (mean) effective membrane time constant." 2997 3315 W2759608560.pdf 2 24 separator 0.9734411 ¶ 3315 3317 W2759608560.pdf 2 25 text 0.9989526 "Tempering vs. short-term plasticity. When trained from data, the energy landscape E (z) is shaped in a way that assigns low energy values (modes) to the samples in the training data. If this dataset is composed of very dissimilar classes, training algorithms tend to separate them by high energy barriers16,33. As their height grows during training, Gibbs sampling becomes increasingly ineffective at covering the entire relevant state space, as reflected by a high correlation between consecutive samples caused by the component-wise update of states 16,17,33 ,34. Consequently, a BM would need longer to converge towards its underlying distribution. This prob- lem becomes particularly inconvenient when dealing with complex, real-world data, or when an agent must rely on the prediction of the network to make a fast decision." 3317 4160 W2759608560.pdf 2 26 separator 0.9556703 ¶ 4160 4162 W2759608560.pdf 2 27 text 0.99202317 "The ability of a sampling-based generative model to jump across energy barriers, also known as mixing, has therefore received significant attention 16,17,35,36. Many of these methods rely on some version of simulated 1:Given adaptive weights " 4162 4410 W2759608560.pdf 2 28 math 0.5801103 =g{}kk 4410 4416 W2759608560.pdf 2 29 text 0.59193474 K 4416 4417 W2759608560.pdf 2 30 math 0.40218672 ¶ 1 4417 4421 W2759608560.pdf 2 31 text 0.5855652 and the initial configuration of the state 4421 4464 W2759608560.pdf 2 32 math 0.63458055 "z1 at temperature 1, k = 1: 2: for t = 1:T (number of iterations) do" 4464 4538 W2759608560.pdf 2 33 text 0.40990064 ¶ 4538 4540 W2759608560.pdf 2 34 table 0.42395094 3: 4540 4543 W2759608560.pdf 2 35 text 0.42478845 Given zt, sample a new state zt+1 4543 4577 W2759608560.pdf 2 36 table 0.3660292 from 4577 4582 W2759608560.pdf 2 37 text 0.37834275 p(z|kt) 4582 4590 W2759608560.pdf 2 38 table 0.36436468 by 4590 4593 W2759608560.pdf 2 39 text 0.38915238 Gibbs sampling. 4593 4609 W2759608560.pdf 2 40 separator 0.8782429 ¶ 4609 4611 W2759608560.pdf 2 41 table 0.48284507 4:Given 4611 4619 W2759608560.pdf 2 42 text 0.46727532 kt, sample kt+1 from proposal distribution q(kt 4619 4667 W2759608560.pdf 2 43 math 0.4861786 +1←kt 4667 4672 W2759608560.pdf 2 44 text 0.483822 ). 4672 4675 W2759608560.pdf 2 45 table 0.41491276 Accept with 4675 4686 W2759608560.pdf 2 46 text 0.4315732 ¶ probability 4687 4701 W2759608560.pdf 2 47 table 0.34154746 : 4701 4702 W2759608560.pdf 2 48 math 0.90508616 "min1,pztktqktktgkt pztknqktktgkt(1,1)(1) (1,) (1) 1  ++←+ ++← + ¶" 4702 4791 W2759608560.pdf 2 49 table 0.3210654 5: 4791 4794 W2759608560.pdf 2 50 text 0.40411302 Update 4794 4800 W2759608560.pdf 2 51 table 0.37104428 adaptive 4800 4810 W2759608560.pdf 2 52 text 0.35174212 adjust 4810 4816 W2759608560.pdf 2 53 table 0.3910453 ing factors: 4816 4828 W2759608560.pdf 2 54 math 0.87472653 "¶ g gI ki iK (1 () ), 1, ,it it tt 11γ =+ == ....++ 6: end for" 4829 4896 W2759608560.pdf 2 55 text 0.4590593 "¶ 7:Collect data: Obtain (dependent) samples from target distribution p(z) by keeping" 4896 4985 W2759608560.pdf 2 56 math 0.44018617 k = 4985 4989 W2759608560.pdf 2 57 text 0.40125093 1. 4989 4992 W2759608560.pdf 2 58 separator 0.995291 ¶ 4992 4994 W2759608560.pdf 2 59 title 0.93282276 Table 1. Adaptive simulated tempering. 4994 5033 W2759608560.pdf 2 0 text 0.99581474 "effect of rs1057035 by the PS software (Power and the Sample Size Calculations version 1.0.17) and found that in the case of OR = 0.65 (dominant model), our sample could reach 78.8% of the statistical efficacy. Secondly, it is a hospital-based case-control study and inherent selection bias cannot be completely excluded." 0 329 W1996127604.pdf 5 1 separator 0.89345187 ¶ 329 331 W1996127604.pdf 5 2 text 0.99903715 "However, we applied a rigorous epidemiological design in selecting study subjects and used further statistical adjustment for known risk factors to minimize potential biases. Thirdly, since the intensity and duration of smoking and drinking were absent in this study, it was difficult to do future analysis for such exposure variables. Last, we only selected miRNA-binding SNPs for genotyping and could not evaluate the relationship between other potentially functional SNPs in miRNA processing genes and HNC risk. Thus, larger, well-designed epidemiological studies with ethnically diverse populations are warranted to confirm and expand our findings." 331 1004 W1996127604.pdf 5 3 title 0.98844415 Supporting Information 1004 1026 W1996127604.pdf 5 4 separator 0.99384236 ¶ 1026 1028 W1996127604.pdf 5 5 title 0.5089537 Table S1 The 1028 1041 W1996127604.pdf 5 6 caption 0.39999023 analysis for 1041 1054 W1996127604.pdf 5 7 title 0.38122728 the 1054 1058 W1996127604.pdf 5 8 caption 0.45269614 effect 1058 1065 W1996127604.pdf 5 9 title 0.37092668 of 1065 1069 W1996127604.pdf 5 10 caption 0.40658474 variables on ORs 1069 1085 W1996127604.pdf 5 11 table 0.39536238 ¶ 1085 1087 W1996127604.pdf 5 12 caption 0.4228014 in models. 1087 1099 W1996127604.pdf 5 13 text 0.31228793 NOTE 1099 1103 W1996127604.pdf 5 14 caption 0.40751976 :a 1103 1105 W1996127604.pdf 5 15 text 0.30503038 Like 1105 1109 W1996127604.pdf 5 16 caption 0.4260266 lihood ratio test was used to check the 1109 1148 W1996127604.pdf 5 17 table 0.37258133 ¶ 1148 1150 W1996127604.pdf 5 18 caption 0.42146346 difference between 22*log 1150 1176 W1996127604.pdf 5 19 table 0.45595014 Like 1176 1181 W1996127604.pdf 5 20 caption 0.46260366 lihood of the two models.b 1181 1207 W1996127604.pdf 5 21 table 0.33877936 1207 1208 W1996127604.pdf 5 22 separator 0.32426006 ¶ 1208 1209 W1996127604.pdf 5 23 table 0.43689075 Compare 1209 1217 W1996127604.pdf 5 24 caption 0.49622875 d to the first model including 1217 1247 W1996127604.pdf 5 25 table 0.44214576 age 1247 1251 W1996127604.pdf 5 26 caption 0.39517996 , 1251 1252 W1996127604.pdf 5 27 table 0.5113548 "gender, smoking and drinking." 1252 1284 W1996127604.pdf 5 28 separator 0.5678623 ¶ 1284 1286 W1996127604.pdf 5 29 table 0.47656327 (DOCX) 1286 1293 W1996127604.pdf 5 30 separator 0.99549305 ¶ 1293 1295 W1996127604.pdf 5 31 title 0.93944645 Author Contributions 1295 1316 W1996127604.pdf 5 32 separator 0.9922755 ¶ 1316 1318 W1996127604.pdf 5 33 text 0.9628781 "Conceived and designed the experiments: HM HY NC. Performed the experiments: HM HY ZY. Analyzed the data: RW YJ ZH. Contributedreagents/materials/analysis tools: CY ZH HS. Wrote the paper: HM HYNC." 1318 1518 W1996127604.pdf 5 34 separator 0.9951502 ¶ 1518 1520 W1996127604.pdf 5 35 title 0.7822373 References 1520 1531 W1996127604.pdf 5 36 separator 0.99285924 ¶ 1531 1533 W1996127604.pdf 5 37 bibliography 0.9978236 "1. Blot WJ, McLaughlin JK, Winn DM, Austin DF, Greenberg RS, et al. (1988) Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 48: 3282–3287." 1533 1702 W1996127604.pdf 5 38 separator 0.91261506 ¶ 1702 1704 W1996127604.pdf 5 39 bibliography 0.99818134 "2. Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, et al. (2004) Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst 96: 99–106." 1704 1865 W1996127604.pdf 5 40 separator 0.90664786 ¶ 1865 1867 W1996127604.pdf 5 41 bibliography 0.9978804 "3. da Silva SD, Ferlito A, Takes RP, Brakenhoff RH, Valentin MD, et al. 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Cancer Res 68: 2530–2537.Genetic Variants and Head and Neck Cancer" 6351 6570 W1996127604.pdf 5 92 separator 0.96974874 ¶ 6570 6572 W1996127604.pdf 5 93 paratext 0.98168343 PLOS ONE | www.plosone.org 6 October 2012 | Volume 7 | Issue 10 | e47544 6572 6645 W1996127604.pdf 5 0 paratext 0.7637054 "Review of: ""Multiplicity of solutions for nonlocal fractional equations with nonsmooth potentials""" 0 100 W4388704156.pdf 0 1 separator 0.90593207 ¶ 100 102 W4388704156.pdf 0 2 contact 0.9609367 "Dhatchinamurthi Tamizharasan 1 1 K. S. Rangasamy College of Technology" 102 180 W4388704156.pdf 0 3 separator 0.99463683 ¶ 180 182 W4388704156.pdf 0 4 title 0.9285578 Potential competing interests: 182 213 W4388704156.pdf 0 5 separator 0.9650462 ¶ 213 215 W4388704156.pdf 0 6 text 0.9881374 "No potential competing interests to declare. A specific category of nonlocal fractional Laplacian problems that involve nonsmooth potential has been reviewed. Then, the utilization of an abstract critical point theorem for nonsmooth functionals developed by Servadei and Valdinoci, and combining it with the analytical framework on fractional Sobolev Space has been well-analyzed. In this paper, the authors mainly focus the existence of at least three weak solutions for nonlocal fractional problems. Also, this work generalizes and improves upon certain results presented in the existing literature. The basic preliminaries of this paper are enough to understand the main result contents. Also, I appreciate the authors for utilizing the existing results to prove their results. In this article, the hypotheses for described functions F, G, and H are well defined and equipped." 216 1113 W4388704156.pdf 0 7 separator 0.98821664 ¶ 1113 1115 W4388704156.pdf 0 8 paratext 0.84204215 "Page 8 ," 1115 1126 W4388704156.pdf 0 9 separator 0.84036803 ¶ 1127 1129 W4388704156.pdf 0 10 title 0.9747484 Remark 3.1 1129 1140 W4388704156.pdf 0 11 separator 0.90029144 ¶ 1140 1143 W4388704156.pdf 0 12 text 0.9267168 ", Check the hypothesis consideration... (H 4 ) is not described." 1143 1212 W4388704156.pdf 0 13 separator 0.6048708 ¶ 1212 1214 W4388704156.pdf 0 14 text 0.9984702 "Page 8, the proof of Lemma 3.1 is clearly and remarkably proved. They showed the monotonicity of I' , but I cannot understand that how to showed the fact I' is strictly monotonic from the above result." 1214 1418 W4388704156.pdf 0 15 separator 0.78032804 ¶ 1422 1424 W4388704156.pdf 0 16 text 0.99896604 Lemma 3.2 is proved by using Hahn-Banach theorem to show the result of the lemma. 1424 1506 W4388704156.pdf 0 17 separator 0.9233996 ¶ 1507 1509 W4388704156.pdf 0 18 text 0.9760655 The proof of theorem 3.1, Line 2, please abbreviate the l.s.c. Is this lower semicontinuous? 1509 1602 W4388704156.pdf 0 19 separator 0.6047988 ¶ 1602 1604 W4388704156.pdf 0 20 text 0.88188106 "Please describe for getting the equation (3.7) from G 3 and G 4 ." 1604 1679 W4388704156.pdf 0 21 separator 0.8346777 ¶ 1680 1682 W4388704156.pdf 0 22 text 0.98772323 The technical part of the theorem is executed well. 1682 1734 W4388704156.pdf 0 23 separator 0.98412764 ¶ 1735 1737 W4388704156.pdf 0 24 paratext 0.94538397 "Qeios, CC-BY 4.0 · Review, November 15, 2023 Qeios ID: H121Q6 · https://doi.org/10.32388/H121Q6 1 /" 1737 1854 W4388704156.pdf 0 25 separator 0.7833134 ¶ 1854 1856 W4388704156.pdf 0 26 paratext 0.6868699 1 1856 1858 W4388704156.pdf 0 0 paratext 0.98373926 88 0 2 W2994094954.pdf 17 1 separator 0.9863497 ¶ 2 4 W2994094954.pdf 17 2 bibliography 0.984357 "European Commission (2008). Improving competences for the 21st century: An agenda for European cooperation on schools . Brussels: European Commission. Retreived 15 March 2012 from http:// ec.europa.eu/education/school21/sec2177_en.pdf Fullan, M. (1993). Change forces: Probing the depths of educational reform. London: Falmer Press." 4 342 W2994094954.pdf 17 3 separator 0.9751273 ¶ 342 344 W2994094954.pdf 17 4 bibliography 0.998061 Goodlad, J. I. (1991). Why We Need a Complete Redesign of Teacher Education. Educational Leadership , 49(3), 4-6, 8-10. 344 464 W2994094954.pdf 17 5 separator 0.9817568 ¶ 464 466 W2994094954.pdf 17 6 bibliography 0.9965886 "Hargreaves, A. (2003). Teaching in the Knowledge Society: Education in the Age of Insecurity. Maidenhead: Open University Press." 466 598 W2994094954.pdf 17 7 separator 0.96979195 ¶ 598 600 W2994094954.pdf 17 8 bibliography 0.99804974 Hargreaves, A., & Fullan, M. G. (1992). Understanding Teacher Development . New Y ork: Cassell. 600 696 W2994094954.pdf 17 9 separator 0.9626683 ¶ 696 698 W2994094954.pdf 17 10 bibliography 0.99802554 Hytonen, J., Pucko, C., & Smyth G. (2003). The restructuring of teacher education – a case study from Slovenia. The Three C’s: Clarity, Consistency and Commitment. Norma , 9(2-3), 25-38. 698 885 W2994094954.pdf 17 11 separator 0.9810783 ¶ 885 887 W2994094954.pdf 17 12 bibliography 0.9981268 Huizen, P ., Oers, B., & Wubbels, T. (2005). A Vygotskian perspective on teacher education. Journal of Curriculum Studies , 37(3), 267-290. 887 1027 W2994094954.pdf 17 13 separator 0.9807466 ¶ 1027 1029 W2994094954.pdf 17 14 bibliography 0.9849492 "Ikonomi, E., Musai, B., & Sotirofski, K. (2010). Mapping policies and practices for the preparation of teachers for inclusive education in contexts of social and cultural diversity – Albania country report. Turin: European Training Foundation." 1029 1279 W2994094954.pdf 17 15 separator 0.9732832 ¶ 1279 1281 W2994094954.pdf 17 16 bibliography 0.9978526 "Kafedžić, L., Pribišev Beleslin, T., & Džemidžić Kristiansen, S. (2010). Mapping policies and practices for the preparation of teachers for inclusive education in contexts of social and cultural diversity – Bosnia and Herzegovina country report. Turin: European Training Foundation.Kidd, J. K., Sanchez, S. Y ., & Thorp, E. K. (2008). Defining moments: Developing culturally responsive dispositions and teaching practices in early childhood pre-service teachers. Teaching and Teacher Education , 24, 316-329." 1281 1799 W2994094954.pdf 17 17 separator 0.98539835 ¶ 1799 1801 W2994094954.pdf 17 18 bibliography 0.99781555 "Leclercq, J.-M. (1996). Teachers in a Context of Change. European Journal of Education, 31(1), 73-84.Macura-Milovanović, S., Gera, I., & Kovačević, M. (2010). Mapping policies and practices for the preparation of teachers for inclusive education in contexts of social and cultural diversity – Serbia country report. Turin: European Training Foundation." 1801 2160 W2994094954.pdf 17 19 separator 0.97649455 ¶ 2160 2162 W2994094954.pdf 17 20 bibliography 0.9979954 "Macura-Milovanović, S., Pantić, N., & Closs, A. (2012). The rationale for a wider concept of Inclusive Education for teacher education: A case-study of Serbia. Prospects , 42, 19-39." 2162 2348 W2994094954.pdf 17 21 separator 0.97910905 ¶ 2348 2350 W2994094954.pdf 17 22 bibliography 0.9979399 Margalef Garcia, L. (2011). Encouraging Teachers’ and Students’ Innovation with the Support of Teacher Learning Communities. Ceps Journal, 1(1), 133-152. 2350 2504 W2994094954.pdf 17 23 separator 0.9809253 ¶ 2504 2506 W2994094954.pdf 17 24 bibliography 0.9978226 "Milić, T., Marić, A., Bošković, V ., & Šćepović, V . (2010). Mapping policies and practices for the preparation of teachers for inclusive education in contexts of social and cultural diversity – Montenegro country report. Turin: European Training Foundation." 2506 2768 W2994094954.pdf 17 25 separator 0.9745271 ¶ 2768 2770 W2994094954.pdf 17 26 bibliography 0.9979206 "Miclea, M. (2003). Institutional-Level Reform and the Bologna Process: The Experience of Nine Universities in South East Europe. Higher Education in Europe, 28 (3), 259-272." 2770 2947 W2994094954.pdf 17 27 separator 0.9753871 ¶ 2947 2949 W2994094954.pdf 17 28 bibliography 0.99792933 "Miller, P ., & Stayton, V . (2006). Interdisciplinary teaming in teacher preparation’ . Teacher Education and Special Education , 29(1), 56-68." 2949 3096 W2994094954.pdf 17 29 separator 0.97938025 ¶ 3096 3098 W2994094954.pdf 17 30 bibliography 0.99764186 "Niemi, H. (2011). Educating Student Teachers to Become High Quality Professionals – A Finnish Case. CEPS Journal, 1(1), 43-65.teacher education and higher education reforms" 3098 3274 W2994094954.pdf 17 0 paratext 0.97920036 "Intern ational Journal of Electrical and Computer Engineering (IJECE) Vol. 10, No. 3, June 2020, pp. 2997~3006 ISSN: 2088 -8708 , DOI: 10.11591/ ijece .v10i3.pp2997 -3006  2997 ¶ Journal homepage : http://ijece.iaescore.com/ind ex.php/IJECE" 0 258 W2997293043.pdf 0 1 title 0.7746216 "Optimized BER for channel equalizer using cuckoo search and neural network" 259 337 W2997293043.pdf 0 2 separator 0.9703634 "¶ ¶" 339 349 W2997293043.pdf 0 3 contact 0.99240726 "Swati Katwal1, Vinay Bhatia2 1Department of Electronics and Communication Engineering , Baddi University of Emerging Sciences and Technology, India 2Department of Electronics and Communication Engineering, Chandigarh Engineering College, India" 349 606 W2997293043.pdf 0 4 separator 0.6818225 608 609 W2997293043.pdf 0 5 contact 0.53995657 ¶ 609 610 W2997293043.pdf 0 6 separator 0.90357965 ¶ ¶ 612 618 W2997293043.pdf 0 7 title 0.9403047 Article Info ABSTRACT 618 642 W2997293043.pdf 0 8 separator 0.96863836 ¶ 644 646 W2997293043.pdf 0 9 paratext 0.4460001 Article 646 654 W2997293043.pdf 0 10 title 0.45928544 history 654 662 W2997293043.pdf 0 11 paratext 0.65677613 : 662 663 W2997293043.pdf 0 12 separator 0.49729174 ¶ 665 667 W2997293043.pdf 0 13 paratext 0.6337777 "Received Apr 16 , 2019 Revised Dec 5 , 2019 Accepted Dec 10 , 2019" 667 743 W2997293043.pdf 0 14 text 0.9993851 "The digital data transfer faces issues regarding Inter -Symbol Interference (ISI); t herefore, the error rate becomes dependent upon channel estimation and its equalization. This paper focuses on the development of a method for optimizing the channel data to improve ISI by utilizing a swarm intelligence series algorithm termed as Cuckoo Se arch (CS). The adjusted data through CS is cross -validated using Artificial Neural Network (ANN). The data acceptance rate is considered with 0 -10% marginal error which varies in the given range with different bit streams. The performance evaluation of the proposed algorithm using the Average Bit Error Rate (A -BER) and Logarithmic Bit Error Rate (L -BER) had shown an overall improvement of 30-50% when compared with the Kalman filter based algorithm." 745 1576 W2997293043.pdf 0 15 title 0.85640544 Keyword s: 1577 1588 W2997293043.pdf 0 16 separator 0.953284 ¶ 1589 1591 W2997293043.pdf 0 17 table 0.637252 "ANN Channel estimation CS Equalization" 1591 1641 W2997293043.pdf 0 18 separator 0.979772 ¶ 1643 1645 W2997293043.pdf 0 19 paratext 0.8594303 "Copyright © 2020 Institute of Advanced Engineering and Science . All rights reserved ." 1645 1736 W2997293043.pdf 0 20 separator 0.9541534 ¶ 1737 1739 W2997293043.pdf 0 21 contact 0.9960153 "Corresponding Author: Swati Katwal , Department of Electronics and Communication Engineering , Baddi University of Emerging Sciences and Technology, Solan , India . Email: engg.swati@yahoo.co.in" 1739 1953 W2997293043.pdf 0 22 separator 0.5825726 1955 1956 W2997293043.pdf 0 23 contact 0.7089421 ¶ 1956 1957 W2997293043.pdf 0 24 separator 0.8982407 ¶ ¶ 1959 1965 W2997293043.pdf 0 25 title 0.99160856 1. INTRODUCTION 1965 1981 W2997293043.pdf 0 26 separator 0.9951939 ¶ 1983 1985 W2997293043.pdf 0 27 text 0.99953455 "Digital Communication (DC) provides digital data transfer with high transfer rate [1 -2]. The average power of the transmitted signal reduces as the distance betw een transmitter and receiver surges. The noise comes in the form of disturbance and Inter -Symbol Interference (ISI) in the received signal. Figure 1 shows the occurrence of ISI in the received signal. It is seen that due to multipath propagation of the tra nsmitted signal, the strength of the received signal reduces due to the presence of buildings and another obstacle like airplane and trees etc." 1985 2565 W2997293043.pdf 0 28 separator 0.9510006 ¶ 2567 2569 W2997293043.pdf 0 29 text 0.9996792 "In this paper, the authors have addressed the ISI distortions and propose an approach to reduce this unwanted p henomenon to improve the reliability of the communication.Basically, there are two main causes of occurring ISI. These are non -linear frequency between the channels and multipath propagation. Many attempts have been made by the researchers to reduce the in terference effect. There are various algorithms and filter proposed by scholars to combat the interference effect. For instance, Kalman Filter (KF) is widely used to reduce the ISI and channel interference effects. This filter is used to linearize the nonl inear models [3]. If the data is well structured, it results in a balanced cha nnel estimation whichresults in a minimum error rate. Although KF and Extended Kalman Filter (EKF ) are used worldwide to rectify the channel data, it lacks in adaptive filtering [4]. Equalizers are used in the adaptive filters. Figure 2 shows the use of equalizer between the transmitter and the receiver. The data is transferred from transmitter to receiver. But, the transfer data stream cannot be kept homogenous throughout [5 -6]. For estimating the time - varying channel coefficients different algorithms are available. Due to the simpli city of the adaptive algorithm, the coefficients of the channel are estimated using Least Mean Square (LMS) algorithm." 2569 3977 W2997293043.pdf 0 0 paratext 0.9670216 ¶ Language and Literacy Volume 21, Issue 3, 2019 Page 6 1 120 W3037920942.pdf 0 1 separator 0.81698763 ¶ ¶ 121 128 W3037920942.pdf 0 2 title 0.9810649 The Meeting of Multiple Words and Worlds 128 169 W3037920942.pdf 0 3 separator 0.8732936 "¶ ¶" 171 181 W3037920942.pdf 0 4 contact 0.8942309 "GALICIA S.T. BLACKMAN University of Calgary" 181 229 W3037920942.pdf 0 5 separator 0.9764663 ¶ ¶ 231 237 W3037920942.pdf 0 6 title 0.9516612 Abstract 237 246 W3037920942.pdf 0 7 separator 0.9955441 ¶ 248 250 W3037920942.pdf 0 8 text 0.9993106 "As a newcomer to Canadian culture, I present an interpretive rendering of my encounters with settler and Indigenous relations. It is my humble attempt to respond to the Truth and Reconciliation Calls to Action ([TRC], 2015) for newcomers, by providing insight into what newcomers might experience in r esponse to the complexities of Indigenous and settler dialogues. Newcomers are diverse groups, on the fringes of Indigenous -settler relations discourse, and outside of the protocols to enter such dialogues. Therefore, I ask, where and when can newcomers, t emporary or long term, enter the dialogues in meaningful, respectful ways? I came to recognize that as a newcomer the more appropriate course of action would be to wait to be invited into the conversation; but that does not absolve me of the responsibility to inform myself about Indigenous -settler relations and confront my discomforts with how I am implicated in these relations. This led me to inquire, can newcomers be of value in the ways multiple ethnic groups live together, in a good way? Using a hermene utic and mythopoetic lens I present a series of vignettes that attempt to grapple with these questions, to contribute to the discourse of responses to the Calls to Action (TRC, 2015)." 250 1554 W3037920942.pdf 0 9 separator 0.98826146 "¶ ¶" 1556 1566 W3037920942.pdf 0 10 title 0.98596317 The Meeting of Multiple Words and Worlds 1566 1607 W3037920942.pdf 0 11 separator 0.9841081 ¶ ¶ 1609 1615 W3037920942.pdf 0 12 bibliography 0.8244164 ...myth 1615 1621 W3037920942.pdf 0 13 text 0.6309958 s 1621 1622 W3037920942.pdf 0 14 bibliography 0.68933773 are 1622 1627 W3037920942.pdf 0 15 text 0.6353389 actually 1627 1635 W3037920942.pdf 0 16 bibliography 0.5597592 1635 1636 W3037920942.pdf 0 17 text 0.7347172 truths about culture and conventional views of history that 1636 1695 W3037920942.pdf 0 18 bibliography 0.86494005 ¶ 1696 1698 W3037920942.pdf 0 19 text 0.5438445 have 1698 1703 W3037920942.pdf 0 20 bibliography 0.59227 both 1703 1708 W3037920942.pdf 0 21 text 0.6305558 been 1708 1713 W3037920942.pdf 0 22 bibliography 0.6825397 deeply 1713 1720 W3037920942.pdf 0 23 text 0.59428537 influenced 1720 1731 W3037920942.pdf 0 24 bibliography 0.5694987 by the stories 1731 1746 W3037920942.pdf 0 25 text 0.7200457 of our country that we have been 1746 1779 W3037920942.pdf 0 26 bibliography 0.85993636 ¶ 1780 1782 W3037920942.pdf 0 27 text 0.74404454 told in school 1782 1797 W3037920942.pdf 0 28 bibliography 0.970527 . (Donald, 2009, p. 3) 1797 1819 W3037920942.pdf 0 29 separator 0.94609 ¶ ¶ 1821 1827 W3037920942.pdf 0 30 text 0.9954417 "For new Canadians, many of whom carry their own traumatic memories of colonial violence, racism, and oppression, finding common ground as Treaty people involves learning about the history of Aboriginal peoples and finding ways to build stronger relationships of solidarity with them." 1827 2123 W3037920942.pdf 0 31 separator 0.88160443 ¶ 2125 2127 W3037920942.pdf 0 32 bibliography 0.98553175 (Truth and Reconciliation Commission, 2015, p. 312) 2127 2179 W3037920942.pdf 0 33 separator 0.79805905 ¶ ¶ 2180 2186 W3037920942.pdf 0 34 bibliography 0.74268466 We call 2186 2195 W3037920942.pdf 0 35 text 0.8258228 upon the federal government, in collaboration with the national Aboriginal 2195 2269 W3037920942.pdf 0 36 bibliography 0.7467569 ¶ 2271 2273 W3037920942.pdf 0 37 text 0.7681816 organizations, to revise the information kit for newcomers to Canada 2273 2342 W3037920942.pdf 0 38 bibliography 0.95738304 ".... (Truth and Reconciliation Commission, 2015, p. 315)" 2342 2400 W3037920942.pdf 0 39 separator 0.8774858 ¶ ¶ 2402 2408 W3037920942.pdf 0 40 text 0.998423 "As a relative newcomer to Canadian culture I present an interpretive rendering of my encounters with the themes and concerns r egarding settler and Indigenous relations which have unfolded around me . This paper is my humble attempt to consider how I may enter the dialogues between Indigenous and se ttler groups, through an examination of my shifting experiences and perspectives. I state upfront that I have much to learn from these" 2408 2858 W3037920942.pdf 0 0 paratext 0.956656 "ISSN: 2320 -5407 Int. J. Adv. Res. 7(3), 1024 -1029 1029" 0 141 W2938497771.pdf 5 1 separator 0.98740923 ¶ 143 145 W2938497771.pdf 5 2 bibliography 0.99787056 "8. Vijayalakshmi, K ., Punitha, N., Mangalam, M., Selvan, S.A., Green synthesis of schiff base and its complex using natural acid catalyst under microwave condition, International Journal of Nano Corrosion Science and Engineering , 2015, 2, 31 -36." 146 401 W2938497771.pdf 5 3 separator 0.97738683 ¶ 402 404 W2938497771.pdf 5 4 bibliography 0.9978212 "9. Deivanayagam, P., Bhoopathy, R.P., Thanikaikarasan, S., Synthesis, characterization, antimicrobial, analgesic and CNS studies of Schiff base Cu (II) complex derived from 4 -choro -o-phenylene diamine, International Journal of Advanced Chemistry , 2014, 2, 166 -170." 404 679 W2938497771.pdf 5 5 separator 0.9764229 ¶ 680 682 W2938497771.pdf 5 6 bibliography 0.99793863 "10. Ashraf, M.A., Mahmood, K., Wajid, A., Synthesis, characterization and biological activity of schiff bases, International Conference on Chemistry and Chemical Process , 2011, 10, 1 -7." 682 873 W2938497771.pdf 5 7 separator 0.97343516 ¶ 874 876 W2938497771.pdf 5 8 bibliography 0.9980536 "11. Elmali, A., Kabak, M., Elerman, Y., Keto -enol tautomerism, conformations a nd structure of N -(2-hydroxy -5- methylphenyl), 2 -hydroxy benzaldehyde imine, Journal of Molecular Structure, 2000, 477, 151 -158." 876 1092 W2938497771.pdf 5 9 separator 0.97788405 ¶ 1093 1095 W2938497771.pdf 5 10 bibliography 0.9979894 "12. Ramadhan, U.H., Haddad, H.M., Ezaria, Z.G., Synthesis of schiff bases complexes as anti -inflammatory agents, World Journal of Ph armacy and Pharmaceutical Sciences , 2016, 5, 98 -108." 1095 1287 W2938497771.pdf 5 11 separator 0.974111 ¶ 1288 1290 W2938497771.pdf 5 12 bibliography 0.99800116 "13. Muzammil, K., Trivedi, P., Khetani, D.B., Synthesis and characterization of schiff base m -nitro aniline and their complexes, Research Journal of Chemical Sciences , 2015, 5, 52 -55." 1290 1481 W2938497771.pdf 5 13 separator 0.9689418 ¶ 1483 1485 W2938497771.pdf 5 14 bibliography 0.9976213 "14. Bader, N.R., Applicat ions of schiff’s bases chelates in quantitative analysis -A review, Rasayan J. Chem , 2010, 3, 660 -670." 1485 1619 W2938497771.pdf 5 15 separator 0.97075623 ¶ 1620 1622 W2938497771.pdf 5 16 bibliography 0.9973831 "15. Arafa, W.A.A., Shaker, R.M., Facile green chemistry approaches towards the synthesis of bis -Schiff bases using ultrasound versus microwave and convention al method without catalyst, General papers, 2016, 3, 187 - 201." 1622 1851 W2938497771.pdf 5 17 separator 0.98295844 ¶ 1852 1854 W2938497771.pdf 5 18 bibliography 0.99781847 "16. Wahab, A., Haider, S.S., Mahmood, I., Mahmood, T., Sherwani, S.K., Kanwal, S., Synthesis of schiff bases from natural products and their remarkable antimicrobial and antioxidant activity, FUUAST J. BIOL , 2014, 4, 27-32." 1854 2086 W2938497771.pdf 5 19 separator 0.9808484 ¶ 2087 2089 W2938497771.pdf 5 20 bibliography 0.9979209 "17. Kasuan, N., Muhammad, Z., Yusoff, Z., Rahiman, M.H.F., Taib, M.N., Haiyee, Z.A., Extraction of Citrus hystrix D.C (Kaffir lime) essential oil using automated steam distillation process: Analysis of volatile compounds, Malaysian J ournal of Analytical Sciences, 2013, 17, 359 -369." 2089 2382 W2938497771.pdf 5 0 paratext 0.9879173 2423 0 4 W3035748381.pdf 10 1 separator 0.8399296 ¶ 4 6 W3035748381.pdf 10 2 title 0.8223781 Modeling intracranial aneurysm stability and growth: an integrative mechanobiological 6 92 W3035748381.pdf 10 3 paratext 0.728736 ... 92 93 W3035748381.pdf 10 4 separator 0.6730626 93 94 W3035748381.pdf 10 5 paratext 0.84221244 ¶ 1 3 94 99 W3035748381.pdf 10 6 separator 0.99103475 ¶ 99 101 W3035748381.pdf 10 7 text 0.9994644 "in size and a prominant secondary bleb develops on the upstream region of the aneurysm sac where a region of low WSS is located. This is facilitated by a feedback mechanism whereby the regions of low WSS enlarge in size as the aneu-rysm enlarges (compare Fig. 13b, c)." 101 374 W3035748381.pdf 10 8 separator 0.98943293 ¶ 374 376 W3035748381.pdf 10 9 text 0.97407794 "Figure 14 illustrates FAR at t=0 and the spatial distribu- tions of WSSAR at t=0 and t=2 . Regions of high WSSAR are associated with oscillatory flow and we hypothesize that in these regions the endothelium will have an irregular mor - phology. In these locations, i.e. the white regions of Fig. 14a where FAR=1 , degradation is maximal. For this example, FAR does not have localized maxima and consequently the whole IA sac is seen to enlarge without the development of focal secondary blebs." 376 894 W3035748381.pdf 10 10 separator 0.97721773 ¶ 894 896 W3035748381.pdf 10 11 text 0.98890215 "The impact on the blood flow velocity field of distinct WSS-related degradation hypotheses is evident in Fig. 15, which compares the velocity streamline from the initial homeostasis (common to all degradation methods) to that of each resulting configuration." 896 1162 W3035748381.pdf 10 12 title 0.99019736 3.3 Stabilization 1162 1180 W3035748381.pdf 10 13 separator 0.9964497 ¶ 1180 1182 W3035748381.pdf 10 14 text 0.9901348 "Figure 16 illustrates the collagen fiber stretch distributions in the final stabilized state for low-WSS driven enlargement (upper) and high-WSSAR driven enlargement (lower). As material is degraded and the IA sac enlarges, the fiber stretches increase to maintain mechanical equilibrium. As the stabilization mechanism is a point-wise relation, see Eq. 15, the mechanobiological equilibrium at the final home- ostatic state contains a spatially-variable attachment stretch field. It can be seen that the magnitudes of the attachment stretch distribution (see Fig. 16) have increased (compare with Fig. 10). More specifically, to stabilize the aneurysm, the attachment stretch distribution evolves from a spatially homogeneous distribution where min/ mode/max attachment stretches of the distribution are 1.01/1.05/1.1 to a spatially heterogeneous distribution where these values increase up to 1.07/1.12/1.17, respectively." 1182 2122 W3035748381.pdf 10 15 separator 0.99622893 ¶ 2122 2124 W3035748381.pdf 10 16 title 0.9853856 4 Discussion 2124 2138 W3035748381.pdf 10 17 separator 0.99645245 ¶ 2138 2140 W3035748381.pdf 10 18 text 0.9997803 We have presented the first Fluid-Solid-Growth frame-work to model IA growth and stabilization for personalized (image-based) IA geometries. Two illustrative scenarios to drive IA enlargement are presented: low WSS and com-plex, oscillatory flow. We propose a novel approach to link endothelial morphology (aligned vs. irregular) to a novel pulsatile flow metric (WSSAR) and subsequently localized degradation of the tissue. Moreover, the model integrates a mechanism to account for aneurysm stabilization, i.e. adap-tion of the adventitial collagen fabric via remodelling of the collagen fiber attachment stretch distribution. 2140 2768 W3035748381.pdf 10 19 separator 0.88967437 ¶ 2768 2770 W3035748381.pdf 10 20 text 0.9995554 "The model is fully implemented into Sim4Life, a state-of- the-art simulation platform for computational life sciences (Neufeld et al. 2013). To our knowledge, Sim4Life is the first fully integrative framework for modeling IA evolution of its type: it incorporates user-friendly tools which span from image segmentation to simulation of IA enlargement." 2770 3124 W3035748381.pdf 10 21 separator 0.97876537 ¶ 3124 3126 W3035748381.pdf 10 22 text 0.99973136 "We utilized an isochoric split of the deformation gradi- ent for our finite element (FE) model. It is recognized that this can cause problems for fiber-reinforced materials that lead to FE simulations producing unrealistic behaviour (volumetric swelling) of a material (Sansour 2008; Helfen-stein et al. 2010; Gültekin et al. 2019). Essentially, from an energy minimization perspective, at a critical fiber stretch, it becomes energetically more favourable to swell the material as opposed to stretch along the fiber direction (Zdunek et al. 2014). Interestingly, the (isochoric) fiber stretch at which this occurs can be calculated by consideration of the relative stiffnesses of the bulk modulus and embedded fiber (Zdunek et al. 2014). If a material is modeled to have a stiffness that increases exponentially, then—for physiological consistent" 3126 3979 W3035748381.pdf 10 23 separator 0.98618966 ¶ 3980 3982 W3035748381.pdf 10 24 caption 0.9960659 "Fig. 9 Evolution of the displacement field from the initial loaded geometry (top) to the (initial) homeostatic state (bottom)" 3982 4112 W3035748381.pdf 10 0 paratext 0.9825888 "European Journal of Business and Management www.iiste.org ISSN 2222-1905 (Paper) ISSN 2222-2839 (Online) DOI: 10.7176/EJBM" 0 253 W2980038797.pdf 7 1 separator 0.7858715 ¶ 254 256 W2980038797.pdf 7 2 paratext 0.93958974 "Vol.11, No.16, 2019 ¶ 47" 256 286 W2980038797.pdf 7 3 separator 0.97984517 ¶ 287 289 W2980038797.pdf 7 4 title 0.9910625 Annex (B) Stata Output for Descriptive Statistics 289 340 W2980038797.pdf 7 5 separator 0.97092605 "¶ ¶" 342 352 W2980038797.pdf 7 6 title 0.9785923 Annex (C) Stata Output for Pairwise Correlation 352 401 W2980038797.pdf 7 7 separator 0.87966514 "¶ ¶" 402 412 W2980038797.pdf 7 8 title 0.94675 Annex (D) Stata Output for Multicollinearty Test of VIF 412 469 W2980038797.pdf 7 9 separator 0.9214732 "¶ ¶ ¶ ¶ ¶" 471 505 W2980038797.pdf 7 0 paratext 0.9568489 "PRODUÇÃO CIENTÍFICA1711 Cad. Saúde Pública, Rio de Janeiro, 29(9):1707-1730, set, 2013" 0 88 W4248637382.pdf 4 1 separator 0.9933583 ¶ 88 90 W4248637382.pdf 4 2 title 0.98759866 Resumen 90 98 W4248637382.pdf 4 3 separator 0.99484015 ¶ 98 100 W4248637382.pdf 4 4 text 0.9985267 "La evaluación de la calidad de la producción científica se basa ampliamente, si no exclusivamente, en los in- dicadores bibliométricos cuantitativos, a pesar de las numerosas críticas a los mismos. La reacción de la co-munidad académica se ha acumulado en los últimos años. Después de presentar una evaluación crítica de este modelo, una alternativa cualitativa es expuesta, con el objetivo de eliminar el estímulo excesivo a la producción desenfrenada de artículos de dudosa con- tribución a la ciencia. Se presenta y se discute la crítica al modelo propuesto." 100 681 W4248637382.pdf 4 5 separator 0.9958769 ¶ 681 683 W4248637382.pdf 4 6 title 0.7440497 "Indicadores de Producción Científica; Evaluación de Programas e Instrumentos de Investigación; Sistemas de Créditos y Evaluación de Investigadores; Sistemas de Evaluación de las Publicaciones" 683 881 W4248637382.pdf 4 7 separator 0.9935552 ¶ 881 883 W4248637382.pdf 4 8 title 0.968473 Referências 883 895 W4248637382.pdf 4 9 separator 0.9892741 ¶ 895 897 W4248637382.pdf 4 10 bibliography 0.9933984 "1. Camargo Jr. KR. O rei está nu, mas segue impávido: os abusos da bibliometria na avaliação da ciência. Saúde & Transformação Social 2010; 1:3-8." 897 1050 W4248637382.pdf 4 11 separator 0.96185887 ¶ 1050 1052 W4248637382.pdf 4 12 bibliography 0.99641913 "2. Adler R, Ewing J, Taylor P . Citation statistics – a re- port from the International Mathematical Union (IMU) in cooperation with the International Coun- cil of Industrial and Applied Mathematics (ICIAM) and the Institute of Mathematical Statistics (IMS). Stat Sci 2009; 24:1-14." 1052 1345 W4248637382.pdf 4 13 separator 0.9681021 ¶ 1345 1347 W4248637382.pdf 4 14 bibliography 0.9976069 "3. Krampen G, Becker R, Wahner U, Montada L. On the validity of citation counting in science evalu- ation: content analyses of references and citations in psychological publications. Scientometrics 2007; 71:191-202." 1347 1571 W4248637382.pdf 4 15 separator 0.96702373 ¶ 1571 1573 W4248637382.pdf 4 16 bibliography 0.99759185 4. Lawrence P . Lost in publication: how measure-ment harms science. Ethics Sci Environ Polit 2008; 8:9-11. 1573 1681 W4248637382.pdf 4 17 separator 0.9453912 ¶ 1681 1683 W4248637382.pdf 4 18 bibliography 0.9978466 5. Campbell DT. Assessing the impact of planned social change. Hanover: The Public Affairs Center, Dartmouth College; 1976. 1683 1807 W4248637382.pdf 4 19 separator 0.929971 ¶ 1807 1809 W4248637382.pdf 4 20 bibliography 0.9977554 6. Fanelli D. Do pressures to publish increase scien-tists’ bias? An empirical support from US states data. PLoS One 2010; 5:e10271. 1809 1942 W4248637382.pdf 4 21 separator 0.9579598 ¶ 1942 1944 W4248637382.pdf 4 22 bibliography 0.9935647 "7. Fang FC, Steen RG, Casadevall A. Misconduct ac-counts for the majority of retracted scientific publications. Proc Natl Acad Sci U S A 2012; 109: 17028-33.8. Reinach F . Darwin e a prática da “Salami Science” . http://www.estadao.com.br/noticias/impresso, darwin-e-a-pratica-da-salami-science-, 1026037,0.htm (acessado em 27/Abr/2012)." 1944 2290 W4248637382.pdf 4 23 separator 0.95901 ¶ 2290 2292 W4248637382.pdf 4 24 bibliography 0.9974266 "9. Alberts B. We need to teach science. http://revista- pesquisa.fapesp.br/en/2012/09/10/bruce-alberts- we-need-to-teach-science/ (acessado em 29/Mai/ 2013)." 2292 2454 W4248637382.pdf 4 25 separator 0.9663707 ¶ 2454 2456 W4248637382.pdf 4 26 bibliography 0.9977674 10. Rorty R. Objectivity, relativism, and truth. Cam-bridge: Cambridge University Press; 1991. 2456 2551 W4248637382.pdf 4 27 separator 0.88417804 ¶ 2551 2553 W4248637382.pdf 4 28 bibliography 0.99718046 "11. Rorty R. Philosophy and the mirror of nature. Princeton: Princeton University Press; 2009." 2553 2651 W4248637382.pdf 4 29 separator 0.9421557 ¶ 2651 2653 W4248637382.pdf 4 30 bibliography 0.9976916 "12. Popper K. The sociology of knowledge. In: Stehr N, Grundmann R, editors. Knowledge: critical con- cepts. V: sociology of knowledge and science. New York: Routledge; 2005. p. 63-74." 2653 2846 W4248637382.pdf 4 31 separator 0.9686071 ¶ 2846 2848 W4248637382.pdf 4 32 bibliography 0.9974425 "13. Hacking I. Statistical language, statistical truth, and statistical reason: the self authentication of a style of scientific reasoning. In: McMullin E, edi-tor. The social dimensions of science. Notre Dame: University of Notre Dame Press; 1992. p. 130-57." 2848 3117 W4248637382.pdf 4 33 separator 0.98756486 ¶ 3117 3119 W4248637382.pdf 4 34 paratext 0.9149582 "Recebido em 14/Jun/2013 Aprovado em 25/Jun/2013" 3119 3169 W4248637382.pdf 4 0 paratext 0.90565985 Page number not for citation purposes 1 ¶ 0 44 W1970779219.pdf 0 1 separator 0.73051417 ¶ ¶ 46 52 W1970779219.pdf 0 2 title 0.98888886 "Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review" 52 178 W1970779219.pdf 0 3 separator 0.98644805 ¶ ¶ 180 186 W1970779219.pdf 0 4 contact 0.97974133 "Nissrine EL omairi1,&, Sanae Abourazzak1, Sanae Chaouki1, Samir Atmani1, Moustapha Hida1 ¶ 1Pediatric Department, Hassan II Un iversity Hospital, Fes, Morocco ¶ &Corresponding author: El Omairi Nissrine, Pediatric Department, Hassan II University Hospital, Fes, Morocco ¶" 186 479 W1970779219.pdf 0 5 separator 0.646492 ¶ 481 483 W1970779219.pdf 0 6 paratext 0.52415127 Key words: 483 494 W1970779219.pdf 0 7 text 0.30737823 Epi 494 498 W1970779219.pdf 0 8 paratext 0.3013974 lepsy 498 503 W1970779219.pdf 0 9 text 0.33590415 , carbamazepine, rash 503 524 W1970779219.pdf 0 10 paratext 0.3400092 , DRESS syndrome 524 540 W1970779219.pdf 0 11 separator 0.7939917 ¶ ¶ 542 548 W1970779219.pdf 0 12 paratext 0.98031825 Received: 29/12/2013 - Accepted: 17/02/2014 - Published: 02/05/2014 548 616 W1970779219.pdf 0 13 separator 0.85865295 ¶ ¶ 618 624 W1970779219.pdf 0 14 title 0.8055554 Abstract 624 633 W1970779219.pdf 0 15 separator 0.9948232 ¶ 636 638 W1970779219.pdf 0 16 text 0.99847335 "Drug-induced hypersensitivity or Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug -induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs in volved. Most of the aromatic anticonvulsants, such as phenytoin, phenobarbital, and carbamazepine, can induce DRESS. Culprit drug withdrawal and corticosteroids constituted the ma instay of DRESS treatment. We describe a 6 year -old boy who presented fever a nd rash 4 weeks after starting carbamazepine. Investigation revealed leukocytosis, atypical lymphocytosis, and elevated serum transaminases. The diagnosis of DREES syndrome was made, Carbamazepine was stopped and replaced initially by Clobazam and by Valpr oic acid after discharge, no systemic corticotherapy was prescribed. Symptoms began to resolve within two weeks, and by one month later her laboratory values had returned to normal. The aim of this work is to raise awareness ge neral practitioner and pediat ricians to suspect Dress syndrome in patients who present with unusual complaints and skin findings after starting any antiep ileptic drug." 638 1804 W1970779219.pdf 0 17 separator 0.9123171 "¶ ¶" 1805 1815 W1970779219.pdf 0 18 paratext 0.9827074 Pan African Medical Journal. 2014 ; 18:9 doi:10.11604/pamj.2014.18.9.3799 1815 1890 W1970779219.pdf 0 19 separator 0.5231233 1892 1893 W1970779219.pdf 0 20 paratext 0.9440822 "¶ This article is available online at: http://www.panafrican -med-journal.com/content/ article/18/9/full/ ¶ © Nissrine EL omairi et al. The Pan African Medical Journal - ISSN 1937 -8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creati vecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the or iginal work is properly cited. ¶ ¶ ¶ ¶ ¶ Pan Africa n Medical Journal – ISSN: 1937 - 8688 (www.panafrica n-med-journal.com) Published in partnership with the African Field Epidemiology Network (AFENET). (www.afenet.net) ¶ Case report Open Access" 1893 2629 W1970779219.pdf 0 21 separator 0.5992849 2631 2632 W1970779219.pdf 0 22 paratext 0.5825566 ¶ 2632 2633 W1970779219.pdf 0 23 separator 0.5902662 2635 2636 W1970779219.pdf 0 24 paratext 0.5138682 ¶ 2636 2637 W1970779219.pdf 0 25 separator 0.94265383 ¶ 2639 2641 W1970779219.pdf 0 0 paratext 0.97007555 "Bulletin of Information Technology (BIT) Vol 4, No 1, Maret 2023 , Hal 75 - 80 ISSN 2722 -0524 (media online) DOI 10.47065/ bit.v3i1. 504 https://journal.fkpt.org/index.php/BIT ¶ Copyright © 2022 Edy W idodo , Page 77 Jurnal BIT is licensed under a Creative Commons Attribution 4.0 International License" 0 334 W4390687707.pdf 2 1 separator 0.8600063 ¶ 336 338 W4390687707.pdf 2 2 table 0.8092031 "17 14 18 14 19 13 20 13 21 14 22 12 23 13 24 15 25 12" 339 417 W4390687707.pdf 2 3 separator 0.9902958 ¶ 418 420 W4390687707.pdf 2 4 title 0.9927219 2. Integrasi Data (Data Integration 420 456 W4390687707.pdf 2 5 separator 0.99264884 ¶ 458 460 W4390687707.pdf 2 6 text 0.99563086 "Penggabungan data dari berbagai database ke dalam suatu database baru. Data yang ditambahkan pada tabel berikut meliputi trouble, durasi human error , dan break, stop delivery, u ntuk data lebih lengkapnya dapat dilihat dilembar lampiran." 460 705 W4390687707.pdf 2 7 separator 0.99637836 ¶ 707 709 W4390687707.pdf 2 8 title 0.51431817 Tabel 3. 709 719 W4390687707.pdf 2 9 table 0.98851013 "Data Integration Pemakain ( Roll ) Trouble Durasi ( Menit ) Human Error Break Hasil 15 Run Out Cepat Ya Ya Tidak 14 Run Out Cepat Tidak Tidak Ya 5 Run Out Lama Tidak Tidak Tidak 8 Press Roll Cepat Tidak Ya Tidak 12 Press Roll Cepat Tidak Ya Tidak 11 Press Roll Lama Tidak Ya Ya 11 Press Roll Lama Tidak Ya Tidak 13 Press Roll Lama Tidak Tidak Tidak 9 Press Roll Lama Tidak Ya Ya 7 Press Roll Cepat Tidak Ya Tidak 10 Press Roll Lama Tidak Tidak Tidak 4 Fold Up Cepat Tidak Tidak Tidak 9 Fold Up Lama Tidak Ya Tidak 8 Fold Up Lama Tidak Ya Tidak 11 Fold Up Lama Ya Ya Tidak" 719 1405 W4390687707.pdf 2 10 separator 0.99028707 ¶ 1407 1409 W4390687707.pdf 2 11 title 0.9910356 3. Seleksi Data ( Data Selection ) 1409 1444 W4390687707.pdf 2 12 separator 0.9946362 ¶ 1446 1448 W4390687707.pdf 2 13 text 0.99431777 "Data yang ada pada database sering kali tidak semuanya dipakai, oleh karena itu hanya data yang sesuai untuk dianalisis yang akan diambil dari database, untuk data lebih lengkapnya dapat dilihat dilembar lampiran." 1448 1668 W4390687707.pdf 2 14 separator 0.9961442 ¶ 1670 1672 W4390687707.pdf 2 15 table 0.98491704 "Tabel 4. Data Selection Pemakaian ( Roll ) Trouble Durasi ( Menit ) Human Error Break Stop Delivery 15 Run Out Cepat Ya ya Tidak 14 Run Out Cepat Tidak Tidak Ya 5 Run Out Lama Tidak Tidak Tidak 8 Press Roll Cepat Tidak ya Tidak 12 Press Roll Cepat Tidak ya Tidak 11 Press Roll Lama Tidak ya Tidak 11 Press Roll Lama Tidak ya Ya 13 Press Roll Lama Tidak Tidak Tidak 9 Press Roll Lama Tidak ya Ya 7 Press Roll Cepat Tidak ya Tidak 10 Press Roll Lama Tidak Tidak Tidak 4 Fold Up Cepat Tidak Tidak Tidak" 1672 2295 W4390687707.pdf 2 0 paratext 0.97845644 "1016 1016-1030 Cad. EBAPE.BR, v. 19, no 4, Rio de Janeiro, Out./Dez. 2021. ISSN 1679-3951" 0 95 W4206952507.pdf 0 1 separator 0.9717475 ¶ 95 97 W4206952507.pdf 0 2 title 0.97883934 "Improvisação organizacional: desafios e perspectivas para o ensino-aprendizagem em administração" 97 197 W4206952507.pdf 0 3 separator 0.98700094 ¶ 197 199 W4206952507.pdf 0 4 contact 0.99192923 "Fernanda Paquelet Moreira Barbosa 1 Eduardo Davel 1 1 Universidade Federal da Bahia (UFBA) / Escola de Administração, Salvador – BA, Brasil" 199 343 W4206952507.pdf 0 5 separator 0.9939134 ¶ 343 345 W4206952507.pdf 0 6 title 0.9876499 Resumo 345 352 W4206952507.pdf 0 7 separator 0.99387074 ¶ 352 354 W4206952507.pdf 0 8 text 0.99930954 "A improvisação organizacional é pesquisada há mais de 30 anos, pois ressalta a importância de sofisticar a prática de gestores e líderes frente às imprevisibilidades cada vez mais marcadas na contemporaneidade. Carecemos de uma visão mais atualizada da produção em improvisação organizacional e de uma reflexão sobre de que modo integrá-la na formação do gestor. O objetivo desta pesquisa é sistematizar os avanços na produção acadêmica acerca de improvisação organizacional e discutir sua integração no ensino-aprendizagem da administração. A metodologia de pesquisa consiste num levantamento sistemático da produção acadêmica. Os resultados da pesquisa fornecem um conjunto atualizado de relevâncias e temáticas relacionadas à improvisação organizacional, uma discussão sobre a importância da improvisação organizacional para a pesquisa em ensino-aprendizagem em administração e um conjunto de abordagens educacionais, barreiras e perspectivas que ajudam pesquisas e práticas futuras a melhor integrar a improvisação no ensino-aprendizagem em administração. A principal contribuição deste estudo é inaugurar uma nova orientação de pesquisa : o ensino-aprendizagem da improvisação organizacional ." 354 1578 W4206952507.pdf 0 9 separator 0.96149313 ¶ 1578 1580 W4206952507.pdf 0 10 text 0.6711951 Palavras-chave: 1580 1596 W4206952507.pdf 0 11 bibliography 0.4602048 Improv 1597 1604 W4206952507.pdf 0 12 text 0.5097217 isação organizacional. En 1604 1629 W4206952507.pdf 0 13 bibliography 0.43219095 sino 1629 1633 W4206952507.pdf 0 14 text 0.5521302 -aprendizagem. En 1633 1650 W4206952507.pdf 0 15 bibliography 0.4581641 sino 1650 1654 W4206952507.pdf 0 16 text 0.43021688 da 1654 1657 W4206952507.pdf 0 17 bibliography 0.45863688 improvisação 1657 1670 W4206952507.pdf 0 18 text 0.5330365 . Desafios do ensino. 1670 1691 W4206952507.pdf 0 19 separator 0.9958006 ¶ 1691 1693 W4206952507.pdf 0 20 title 0.98933786 Organizational improvisation: challenges and perspectives for management education 1693 1776 W4206952507.pdf 0 21 separator 0.9799813 ¶ 1776 1778 W4206952507.pdf 0 22 title 0.9872214 Abstract 1778 1787 W4206952507.pdf 0 23 separator 0.9929275 ¶ 1787 1789 W4206952507.pdf 0 24 text 0.9994735 "Organizational improvisation has been researched for over 30 years as it emphasizes the importance of improving the practice of managers and leaders dealing with unpredictability, increasingly stressed in contemporary times. An updated view of academic production in organizational improvisation is necessary, and a reflection on integrating it in management education. This research aims to systematize the advances in academic production on organizational improvisation and discuss its integration in management education. The research methodology consists of a systematic survey of academic production. The research results include: (a) a set of actual relevances and themes related to organizational improvisation, (b) a discussion about the importance of organizational improvisation for management education research, and (c) a set of educational approaches, barriers, and perspectives that help research and future practices to better integrate improvisation in management teaching and learning. The main contribution of this research is to inaugurate a new research orientation: the teaching- learning of organizational improvisation." 1789 2955 W4206952507.pdf 0 25 separator 0.98258984 ¶ 2955 2957 W4206952507.pdf 0 26 bibliography 0.7679582 Keywords : Organizational improvisation. Management education. Teaching improvisation. Teaching challenges . 2957 3066 W4206952507.pdf 0 27 separator 0.9956206 ¶ 3066 3068 W4206952507.pdf 0 28 title 0.9875417 Improvisación organizacional: desafíos y perspectivas para la enseñanza-aprendizaje en Administración 3068 3170 W4206952507.pdf 0 29 separator 0.99447596 ¶ 3170 3172 W4206952507.pdf 0 30 title 0.99112725 Resumen 3172 3180 W4206952507.pdf 0 31 separator 0.99509835 ¶ 3180 3182 W4206952507.pdf 0 32 text 0.9993036 "La improvisación organizacional ha sido investigada durante más de 30 años, ya que enfatiza la importancia de sofisticar la práctica de gestores y líderes ante la imprevisibilidad cada vez más marcada en la actualidad. Necesitamos una visión más actualizada de la producción en improvisación organizacional, así como una reflexión sobre cómo integrarla en la formación de los directivos. El objetivo de esta investigación es sistematizar los avances en la producción académica sobre la improvisación organizacional y discutir su integración en la enseñanza-aprendizaje de la Administración. La metodología de investigación consiste en un relevamiento sistemático de la producción académica. Los resultados de la investigación son: (a) un conjunto de puntos relevantes y temas relacionados con la improvisación organizacional, (b) una discusión sobre la importancia de la improvisación organizacional para la investigación en enseñanza-aprendizaje en Administración, (c) un conjunto de enfoques, barreras y perspectivas educativos que ayudan a las investigaciones y prácticas futuras a integrar mejor la improvisación en la enseñanza y el aprendizaje en Administración . El principal aporte de esta investigación es inaugurar una nueva orientación investigadora : la enseñanza- aprendizaje de la improvisación organizacional ." 3182 4537 W4206952507.pdf 0 33 separator 0.96650064 ¶ 4537 4539 W4206952507.pdf 0 34 bibliography 0.8353402 Palabras clave : Improvisación organizacional. Enseñanza-aprendizaje. Enseñanza de la improvisación. Desafíos de la enseñanza . 4539 4667 W4206952507.pdf 0 35 separator 0.97504556 ¶ 4667 4669 W4206952507.pdf 0 36 paratext 0.96587807 "Artigo submetido em 12 de setembro de 2020 e aceito para publicação em 09 de fevereiro de 2021. DOI: http://dx.doi.org/10.1590/1679-3951220200191" 4669 4817 W4206952507.pdf 0 0 paratext 0.98841166 Energies 2016 ,9, 767 24 of 24 0 30 W2522747841.pdf 23 1 separator 0.99186 ¶ 30 32 W2522747841.pdf 23 2 bibliography 0.9978844 "18. Ceperic, E.; Ceperic, V .; Baric, A. A strategy for short-term load forecasting by support vector regression machines. IEEE Trans. Power Syst. 2013 ,28, 4356–4364. [CrossRef]" 32 213 W2522747841.pdf 23 3 separator 0.9475864 ¶ 213 215 W2522747841.pdf 23 4 bibliography 0.9976555 "19. Lahouar, A.; Slama, J.B.H. Day-ahead load forecast using random forest and expert input selection. Energy Convers. Manag. 2015 ,103, 1040–1051. [CrossRef]" 215 376 W2522747841.pdf 23 5 separator 0.94588876 ¶ 376 378 W2522747841.pdf 23 6 bibliography 0.9978034 "20. Jurado, S.; Nebot, À.; Mugica, F.; Avellana, N. Hybrid methodologies for electricity load forecasting: entropy-based feature selection with machine learning and soft computing techniques. Energy 2015 ,86, 276–291. [CrossRef]" 378 611 W2522747841.pdf 23 7 separator 0.95020103 ¶ 611 613 W2522747841.pdf 23 8 bibliography 0.998098 21. Dudek, G. Short-Term Load Forecasting Using Random Forests. Intell. Systems'2014 2015 ,323, 821–828. 613 718 W2522747841.pdf 23 9 separator 0.94878745 ¶ 718 720 W2522747841.pdf 23 10 bibliography 0.9979727 "22. Wang, J.; Li, L.; Niu, D.; Tan, Z. An annual load forecasting model based on support vector regression with differential evolution algorithm. Appl. Energy 2012 ,94, 65–70. [CrossRef]" 720 909 W2522747841.pdf 23 11 separator 0.8978305 ¶ 909 911 W2522747841.pdf 23 12 bibliography 0.9978768 23. Breiman, L. Random forest. Mach. Learn. 2001 ,45, 5–32. [CrossRef] 911 982 W2522747841.pdf 23 13 separator 0.8838761 ¶ 982 984 W2522747841.pdf 23 14 bibliography 0.99795425 "24. Che, J.X.; Wang, J.Z.; Tang, Y.J. Optimal training subset in a support vector regression electric load forecasting model. Appl. Soft Comput. 2012 ,12, 1523–1531. [CrossRef]" 984 1163 W2522747841.pdf 23 15 separator 0.9384793 ¶ 1163 1165 W2522747841.pdf 23 16 bibliography 0.99790686 "25. Ghofrani, M.; Ghayekhloo, M.; Arabali, A.; Ghayekhloo, A. A hybrid short-term load forecasting with a new input selection framework. Energy 2015 ,81, 777–786. [CrossRef]" 1165 1341 W2522747841.pdf 23 17 separator 0.9216247 ¶ 1341 1343 W2522747841.pdf 23 18 bibliography 0.9978291 "26. Kouhi, S.; Keynia, F. A new cascade NN based method to short-term load forecast in deregulated electricity market. Energy Convers. Manag. 2013 ,71, 76–83. [CrossRef]" 1343 1515 W2522747841.pdf 23 19 separator 0.95365584 ¶ 1515 1517 W2522747841.pdf 23 20 bibliography 0.99797535 "27. Breiman, L.; Friedman, J.H.; Olshen, R.A.; Stone, C.J. Classification and Regression Trees ; Chapman Hall: New York, NY, USA, 1984." 1517 1654 W2522747841.pdf 23 21 separator 0.9443694 ¶ 1654 1656 W2522747841.pdf 23 22 bibliography 0.9980555 "28. Troncoso, A.; Salcedo-Sanz, S.; Casanova-Mateo, C.; Riquelme, J.C.; Prieto, L. Local models-based regression trees for very short-term wind speed prediction. Renew. Energy 2015 ,81, 589–598. [CrossRef]" 1656 1864 W2522747841.pdf 23 23 separator 0.9358964 ¶ 1864 1866 W2522747841.pdf 23 24 bibliography 0.9979702 "29. Sirlantzis, K.; Hoque, S.; Fairhurst, M.C. Diversity in multiple classifier ensembles based on binary feature quantisation with application to face recognition. Appl. Soft Comput. 2008 ,8, 437–445. [CrossRef]" 1866 2080 W2522747841.pdf 23 25 separator 0.9421417 ¶ 2080 2082 W2522747841.pdf 23 26 bibliography 0.99792594 "30. Li, S.; Wang, P .; Goel, L. Short-term load forecasting by wavelet transform and evolutionary extreme learning machine. Electr. Power Syst. Res. 2015 ,122, 96–103. [CrossRef]" 2082 2263 W2522747841.pdf 23 27 separator 0.941531 ¶ 2263 2265 W2522747841.pdf 23 28 paratext 0.97511107 "©2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/)." 2265 2507 W2522747841.pdf 23 0 paratext 0.8725789 9rsos.royalsocietypublishing.org R. Soc. open sci. 4:171101................................................an opposite change at the motor cortex in the TD state following maximal shortening contractions [ 13]. 0 210 W2768450377.pdf 8 1 separator 0.9951523 ¶ 210 212 W2768450377.pdf 8 2 text 0.9995056 "This counterbalancing effect provides insight into how modulations in spinal or supraspinal excitability may occur following active muscle shortening even if motor neuron output, as measured by surface EMG, remains constant [ 13]. Central nervous system excitability was also altered in the isometric steady state following maximal lengthening contractions [ 15]. It was found that the force-enhanced state was associated with increased MEP amplitude and unchanged CMEP amplitude, suggesting an increase in cortical excitability following active lengthening. Collectively, these findings indicate that voluntarycontrol of force during maximal efforts in the history-dependent state of residual force enhancement and TD is associated with changes in excitability of the corticospinal tract." 212 1013 W2768450377.pdf 8 3 separator 0.9868008 ¶ 1013 1015 W2768450377.pdf 8 4 text 0.9997384 "The current study investigated neuromechanical coupling following submaximal contractions in the TD state. It was found that, following active muscle shortening, there was an increase in CMEP amplitude of approximately 10%. As seen in figure 4 e, this was a robust finding, with only two participants showing a modest decrease. This indicates that in the TD state, there is an increase in spinal excitability, andfurther supports the notion of neuromechanical coupling as a phenomenon involved in the history- dependent nature of muscle contraction. There was no observed difference in MEP amplitude between the TD and ISO states, and the variability in data between subjects was considerably larger than CMEPamplitude ( figure 4 f). However, in some subjects, changes in MEP and CMEP amplitudes appear to be negatively related to one another, meaning that an increase or decrease in CMEP amplitude could have been accompanied by an opposite change in MEP amplitude. While this was not observed for all subjects, it is possible that during submaximal contractions, similar to maximal contractions [ 13], the excitatory changes at the spinal level were counterbalanced by reduced excitability at the level of the motor cortex.Future investigations should more closely examine this relationship." 1015 2324 W2768450377.pdf 8 5 separator 0.9972693 ¶ 2324 2326 W2768450377.pdf 8 6 title 0.99428266 4.3. Possiblesensorimotorcontributionstoalteredexcitabilityinthetorque-depressedstate 2326 2412 W2768450377.pdf 8 7 separator 0.99614984 ¶ 2412 2414 W2768450377.pdf 8 8 text 0.9997743 "The cause of increased spinal excitability in the present study is unknown, but it may be related tothe function of sensory afferent feedback mechanisms located in the periphery. The Golgi tendon organ (GTO) is anatomically located in-series with the muscle and aponeurosis at the muscle–tendon junction, and is a mechanoreceptor responsible for monitoring muscle tension and providing inhibitory sensoryfeedback via Ib afferents to the agonist motor neuron pool [ 22]. Firing of Ib afferents is modulated in a tension-dependent manner [ 23], and signals whole-muscle force rather than internal forces related to individual motor units [ 24]. In the present study, torque amplitude was approximately 13% lower in the TD state when compared with the ISO state, so a reduction in Ib afferent firing could have contributed to the larger CMEPs (i.e. increased spinal excitability) observed in TD." 2414 3318 W2768450377.pdf 8 9 separator 0.97499907 ¶ 3318 3320 W2768450377.pdf 8 10 text 0.9997145 "In addition to providing inhibitory feedback to the agonist motor neuron pool at the spinal level, Ib afferents also cause presynaptic inhibition of afferents via primary afferent depolarization [ 22]. Primary afferent depolarization may be used to target other Ib afferents as a negative feedback mechanism [25], but it may also be directed towards Ia afferents [ 26]. Presynaptic inhibition may therefore control the balance of excitatory and inhibitory feedback to the central nervous system, which is critical for voluntary force control [ 22] and could be altered in the history-dependent state. Further, Ib afferents relay information from GTOs to the cerebellum and cerebral cortex via the dorsal and ventral spinocerebellartracts for higher-level proprioceptive processing [ 27]. The precise outcome of this input is unknown, but along with associated messages from skin, joints and other muscle receptors, it may be used for conscious sensation, intentional force adjustments and the voluntary control of movement [ 22]. Reduced muscle force production capacity in the TD state—while maintaining similar levels of activation—may perhaps alter the feedback delivered by these afferents, and could modify the control of force production via thecentral nervous system. Thus, altered afferent feedback provides an exciting area for further research into the effects of the history-dependence of force on nervous system activity and the voluntary control of force." 3320 4813 W2768450377.pdf 8 11 separator 0.99653256 ¶ 4813 4815 W2768450377.pdf 8 12 title 0.98940563 5. Conclusion 4815 4829 W2768450377.pdf 8 13 separator 0.9969981 ¶ 4829 4831 W2768450377.pdf 8 14 text 0.9997562 "The present study investigated alterations to the excitability of the central nervous system in the torque- depressed state as indicated by changes in MEP and CMEP amplitude. Using a paradigm of maintained motor neuron output (i.e. matching of agonist integrated EMG), it was shown that following activeshortening, steady-state isometric torque was significantly less than the torque produced during the purely isometric contractions. Further, it was shown that during contractions in the torque-depressed state, there was a significant increase in CMEP amplitude when compared with contractions in the" 4831 5440 W2768450377.pdf 8 0 title 0.4958656 Compar 0 6 W2932715612.pdf 8 1 paratext 0.54102015 ative cytogenetics 6 25 W2932715612.pdf 8 2 title 0.4927003 among 25 30 W2932715612.pdf 8 3 paratext 0.51180923 Lepor 30 36 W2932715612.pdf 8 4 title 0.5239595 inus 36 40 W2932715612.pdf 8 5 paratext 0.5656978 frid 40 45 W2932715612.pdf 8 6 title 0.5138451 erici and Leporellus 45 66 W2932715612.pdf 8 7 paratext 0.54546833 vittatus 66 75 W2932715612.pdf 8 8 title 0.53305155 population 76 87 W2932715612.pdf 8 9 paratext 0.8526883 s...113 87 94 W2932715612.pdf 8 10 separator 0.9956149 ¶ 94 96 W2932715612.pdf 8 11 text 0.9996318 "this was also observed, differences in the chromosomal position of 45S rDNA were additionally observed between species, with signals in the terminal region of the p arm for L. friderici and in the q arm for L. vittatus . The rDNAs usually present high rates of karyotype rearrangements in evolutionary lineages (Symonová et al. 2013). These sequence movements within karyotypes have been proposed to occur by transposition and/or by transposon-mediated by TEs in a non-homologous recombination mecha - nism (Symonová et al. 2013, Barros et al. 2017a, Glugoski et al. 2018). The L. vittatus specimens from the Aripuanã river presented synteny of 45S rDNA and 5S rDNA, in contrast with the specimens from the Mogi–Guaçu and São Francisco rivers and the L. friderici populations corroborating to high evolutionary chromosomal change level to rDNA sites. The rDNA synteny was also observed in other anostomids, such as L. tri - fasciatus , S. fasciatus and Laemolyta taeniata (Kner, 1858), showing that it is a recurrent chromosomal characteristic of this group (Barros et al. 2017b)." 96 1211 W2932715612.pdf 8 12 separator 0.97316927 ¶ 1211 1213 W2932715612.pdf 8 13 text 0.99949354 "Recently, some studies have proposed that the dispersal of ribosomal sites and changes in their chromosomal location may affect recombination rates in these spe - cific sites, and that these changes can lead to rapid genome divergence (Symonová" 1213 1463 W2932715612.pdf 8 14 caption 0.9964425 "Figure 5. Karyotypes of Leporinus friderici (a, b) and Leporellus vittatus (c, d, e ) submitted to fluores - cence in situ hybridization with (TTAGGG)n probe. Scale bar: 10 μm." 1463 1642 W2932715612.pdf 8 15 separator 0.99631417 ¶ 1642 1644 W2932715612.pdf 8 0 paratext 0.8827806 ARTICLE 0 7 W3165653026.pdf 0 1 separator 0.9446138 ¶ 7 9 W3165653026.pdf 0 2 title 0.984839 "Phonological vs. natural gender cues in the acquisition of German by simultaneous and sequential bilinguals (German –Russian)" 9 139 W3165653026.pdf 0 3 separator 0.9903337 ¶ 139 141 W3165653026.pdf 0 4 contact 0.92016125 Tanja KUPISCH1,2,*, Natalia MITROFANOVA2, and Marit WESTERGAARD2,3 141 208 W3165653026.pdf 0 5 separator 0.51606184 ¶ 208 210 W3165653026.pdf 0 6 contact 0.98233706 "1University of Konstanz, Germany,2UiT The Arctic University of Norway, Norway, and3NTNU Norwegian University of Science and Technology, Norway *Corresponding author: Tanja Kupisch University of Konstanz Department of Linguistics D-78 464 Konstanz Germany E-mail: tanja.kupisch@uni-konstanz.de" 210 509 W3165653026.pdf 0 7 separator 0.92179483 ¶ 509 511 W3165653026.pdf 0 8 paratext 0.9655545 "(Received 11 January 2020; revised 2 September 2020; accepted 2 January 2021; first published online 25 May 2021)" 511 627 W3165653026.pdf 0 9 separator 0.99548787 ¶ 627 629 W3165653026.pdf 0 10 title 0.8581202 Abstract 629 638 W3165653026.pdf 0 11 separator 0.9875071 ¶ 638 640 W3165653026.pdf 0 12 text 0.9970546 "We investigate German –Russian bilingual children ’s sensitivity to formal and semantic cues when assigning gender to nouns in German. Across languages, young children have beenshown to primarily rely on phonological cues, whereas sensitivity to semantic andsyntactic cues increases with age. With its semi-transparent gender assignment system,where both formal and semantic cues are psycho linguistically relevant, German has weakphonological cues compared to other languages, and children have been argued toacquire semantic and phonological rules in tandem. German –Russian bilingual children face the challenge of acquiring two different gender assignment systems simultaneously." 640 1328 W3165653026.pdf 0 13 separator 0.90133405 ¶ 1328 1330 W3165653026.pdf 0 14 text 0.99916023 "We tested 45 bilingual children (ages 4 –10 years) and monolingual controls. Results show that the children are clearly sensitive to phonological cues, while semantic cues play aminor role. However, monolingual and bilingual children have different defaultingstrategies, with monolinguals defaulting to neuter and bilinguals to feminine gender." 1330 1677 W3165653026.pdf 0 15 separator 0.9614723 ¶ 1677 1679 W3165653026.pdf 0 16 text 0.6192984 Keywords: gender assignment; transparency; nonce words; cue mismatch; crosslinguistic influence 1679 1775 W3165653026.pdf 0 17 separator 0.9970914 ¶ 1775 1777 W3165653026.pdf 0 18 title 0.75233024 Introduction 1777 1790 W3165653026.pdf 0 19 separator 0.9911933 ¶ 1790 1792 W3165653026.pdf 0 20 text 0.99216443 "The present study investigates bilingual children ’s sensitivity to phonological and semantic cues in the acquisition of grammatical gender assignment in German. The acquisition of gender by bilingual children has been extensively studied over the past few years, focussing on a number of language combinations and a variety of topics,including acceleration and delay compared to monolinguals (e.g., Eichler, Jansen" 1792 2214 W3165653026.pdf 0 21 bibliography 0.9784854 "& Müller, 2013 ; Egger, Hulk & Tsimpli, 2018 ; Hulk & van der Linden, 2010 ; Kaltsa, Tsimpli & Argyri, 2019 ; Kupisch & Klaschik, 2017 ; Kupisch, Müller & Cantone, 2002 ; Rodina & Westergaard, 2015 ,2017 ), age of onset effects (e.g., Granfeldt, 2018" 2214 2471 W3165653026.pdf 0 22 text 0.53884524 2471 2472 W3165653026.pdf 0 23 bibliography 0.8593592 "; Meisel, 2018" 2472 2488 W3165653026.pdf 0 24 text 0.6849933 ); and the role of 2488 2507 W3165653026.pdf 0 25 bibliography 0.49084187 input 2507 2513 W3165653026.pdf 0 26 text 0.55362356 and 2513 2517 W3165653026.pdf 0 27 bibliography 0.6755281 language use at home (e.g., Gathercole & 2517 2558 W3165653026.pdf 0 28 separator 0.6602566 ¶ 2558 2560 W3165653026.pdf 0 29 paratext 0.9601632 "© The Author(s), 2021. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.Journal of Child Language (2022), 49, 661 –683 doi:10.1017/S0305000921000039 https://doi.org/10.1017/S0305000921000039 Published online by Cambridge University Press" 2560 3078 W3165653026.pdf 0 0 paratext 0.97520703 226 0 3 W2753782435.pdf 15 1 separator 0.98160774 ¶ 3 5 W2753782435.pdf 15 2 title 0.8992037 Análisis normativo sobre medios altern 5 44 W2753782435.pdf 15 3 text 0.71580124 os... 44 49 W2753782435.pdf 15 4 separator 0.87798154 ¶ 49 51 W2753782435.pdf 15 5 text 0.9967445 "social como son: 1. combatir las situaciones delictivas y facilitar la resolución de conflictos que amenacen la seguridad ciudadana –protección de la integridad física de las personas, sus propiedades, el disfrute de los derechos y el cumplimiento de los deberes– mediante el diálogo, la mediación y la conciliación, debiéndose al respecto separar las competencias entre órganos represivos y preventivos, y 2. atribuirle al cuerpo policial de menor rango o jerarquía –la policía comunal–, la encomiable labor de actuar bajo los esquemas de resolución pacífica, como se refiere: (...) el oficial puede actuar como agente de la realidad y factor que facilite la comunicación entre las personas que amenazan con un acto determinado, y las personas con quienes deben negociar. En caso de rehenes o secuestro... o el equipo de negociación táctica pueden constituir la autoridad, mientras que el oficial de policía local señala el proceso de mediación. Si las negociaciones entre la autoridad y el agresor no se llevan a cabo a través de la mediación dirigida por la policía local, es posible delinear un plan que resulte ideal para una solución rápida, aunque desde luego no estamos pronunciándonos a favor de un compromiso hacia la violencia o las amenazas (Folberg & Taylor, 1996, p. 206)." 51 1375 W2753782435.pdf 15 6 separator 0.9917941 ¶ 1375 1377 W2753782435.pdf 15 7 text 0.9978558 "Abordando ahora los preceptos normativos de la Ley Orgánica del Poder Popular de 2010 que regulan los medios alternos de resolución de conflictos, ha de señalarse que se trata de un instrumento jurídico que tiene por objeto desarrollar y consolidar al Poder Popular a través de los diversos medios de participación y organización, reconociéndose el protagonismo del pueblo organizado sobre ese ámbito, ahora bien sobre el tópico objeto de interés se preceptúa a la justicia comunal, la cual hace referencia a los medios alternos de resolución de conflictos siguiendo los preceptos constitucionales del segundo aparte del artículo 258 eiusdem en el enunciado del Arbitraje, la Conciliación, la Mediación y cualesquiera otros medios alternos, como profesa el artículo 21 eiusdem :" 1377 2184 W2753782435.pdf 15 8 separator 0.89042485 ¶ 2184 2186 W2753782435.pdf 15 9 text 0.99815017 "La justicia comunal es un ámbito de actuación del Poder Popular, a través de medios alternativos de justicia de paz que promueven el arbitraje, la conciliación, la mediación y cualquier otra forma de solución de conflictos ante situaciones derivadas directamente del ejercicio del derecho a la participación y a la convivencia comunal, de acuerdo a los principios constitucionales del Estado democrático y social de Derecho y de Justicia, sin contravenir las competencias legales propias del sistema de justicia ordinario (Asamblea Nacional de la República Bolivariana de Venezuela, 2010)." 2186 2794 W2753782435.pdf 15 10 separator 0.97101855 ¶ 2794 2796 W2753782435.pdf 15 11 text 0.9986283 "Este artículo se fundamenta en el reconocimiento concreto de la participación ciudadana de los actores socio-comunitarios –principalmente miembros de los Concejos Comunales y las Comunas–, en detrimento de la competencia exclusiva del municipio de la justicia de paz, lo cual normativamente configura una institucionalidad paralela –llamada justicia comunal–, que contradice el numeral" 2797 3195 W2753782435.pdf 15 0 paratext 0.9559651 Page 2/16Abstract 0 17 W4252029459.pdf 1 1 separator 0.9960371 ¶ 17 19 W4252029459.pdf 1 2 title 0.8838449 Objective 19 29 W4252029459.pdf 1 3 text 0.99429053 "We integrated neoadjuvant chemotherapy (NAC) into the protocol for Enhanced Recovery After Surgery (ERAS) in the management of gastric cancer. This study was aimed at investigating the feasibility and effectiveness of this combined approach." 29 275 W4252029459.pdf 1 4 separator 0.9930319 ¶ 275 277 W4252029459.pdf 1 5 title 0.50723976 277 278 W4252029459.pdf 1 6 text 0.98551726 "Methods A retrospective cohort study was conducted on patients with gastric cancer undergoing cancer treatment at our Department from January 2016 to June 2019. All patients were compliant with the ERAS protocol perioperatively and were divided into an ERAS group and an ERAS + NAC group for the study. The following parameters were compared between the two groups: TNM staging, the choice of the surgical approach, estimated blood loss, operating time, placement of drainage and catheter, the volume of" 278 791 W4252029459.pdf 1 0 paratext 0.9897127 Catalysts 2023 ,13, 259 3 of 11 0 31 W4317930358.pdf 2 1 separator 0.7470838 ¶ 31 33 W4317930358.pdf 2 2 paratext 0.986957 Catalysts 2023 , 13, x 3 of 11 33 65 W4317930358.pdf 2 3 separator 0.9932276 ¶ 67 69 W4317930358.pdf 2 4 text 0.99885803 "to minimize the influence of geometric factors on catalytic activity. It is interesting to find that only CeO 2 can substantially improve the catalytic activity whereas other suppor ts all suppress the activity of BaMnO 3 (Figure 1b) . The results clearly reveal that CeO 2 is critical for the high performance of the BaMnO 3-CeO 2 catalyst." 70 421 W4317930358.pdf 2 5 separator 0.98571694 ¶ ¶ 423 429 W4317930358.pdf 2 6 caption 0.99624467 "Figure 1. Catalytic activity of ( a) BaMnO 3-CeO 2-M and ( b) BaMnO 3-AxOy-M (A = Ce, Zr, Ti, Si and Al). The BaMnO 3-CeO 2-O, BaMnO 3 and CeO 2 samples were also included for comparison. Reaction conditions: 2 vol% NO/He, 1.5 g s cm−3, 500–850 °C." 429 684 W4317930358.pdf 2 7 separator 0.991398 ¶ 685 687 W4317930358.pdf 2 8 text 0.9989191 "Considering that the elevated temperature probably promotes the interaction between the components (Fig ure 1a), the BaMnO 3-CeO 2-M samples were pretreated at 600–800 °C before the catalytic activity test. The 600 °C-treated sample (BaMnO 3-CeO 2-M-600) shows almost similar activity with BaMnO 3-CeO 2-M over the whole temperature range (Fig ure 2a). In contrast, 700 and 800 °C calcination (BaMnO 3-CeO 2-M-700/800) enhances the ac- tivity clearly . The BaMnO 3-CeO 2-M-700 sample shows the highest activity, 26.5%, 40.6% and 50.5% at 650, 700 and 750 °C, respectively , which increases by ~17%, ~20% and ~15% compared with BaMnO 3-CeO 2-M. BaMnO 3-CeO 2-M-800 shows slightly lower activity than BaMnO 3-CeO 2-M-700, but still higher than BaMnO 3-CeO 2-M. Accordingly, the thermal treatment above 600 °C can improve the catalytic activity of BaMnO 3-CeO 2-M." 687 1578 W4317930358.pdf 2 9 separator 0.9439547 ¶ 1579 1581 W4317930358.pdf 2 10 text 0.99271464 "Furthermore, BaMnO 3-CeO 2-M-700 shows a rather stable durability in the 5 vol% O2-containing atmosphere at 800 °C, with only ~11% decrease over more than " 1581 1743 W4317930358.pdf 2 11 separator 0.9309416 ¶ ¶ 1743 1748 W4317930358.pdf 2 12 caption 0.9910199 "Figure 2. (a) Catalytic activity of BaMnO 3-CeO 2-M thermally pre -treated at different temperatures (600, 700 and 800 °C). Reaction conditions: 2 vol% NO/He, 1.5 g s cm−3, 500–850 °C. (b) Durability of BaMnO 3-CeO 2-M-700 in O 2-containing atmosphere. Reaction conditions: 2 vol% NO/He, 5 vol% O 2, 1.5 g s cm−3, 800 °C. 500 h ." 1748 2087 W4317930358.pdf 2 13 separator 0.9914119 ¶ 2088 2090 W4317930358.pdf 2 14 caption 0.9953496 "Figure 1. Catalytic activity of ( a) BaMnO 3-CeO 2-M and ( b) BaMnO 3-AxOy-M (A = Ce, Zr, Ti, Si and Al). The BaMnO 3-CeO 2-O, BaMnO 3and CeO 2samples were also included for comparison. Reaction conditions: 2 vol% NO/He, 1.5 g s cm" 2090 2326 W4317930358.pdf 2 0 title 0.713959 CORRECTION 0 10 W4251281504.pdf 0 1 separator 0.9779898 ¶ 10 12 W4251281504.pdf 0 2 title 0.8570709 "Correction: α-MSH Stimulates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1Independently of AMPK" 12 151 W4251281504.pdf 0 3 separator 0.6009916 ¶ 151 153 W4251281504.pdf 0 4 title 0.6195926 ThePLOS ONE Staff 153 171 W4251281504.pdf 0 5 separator 0.992385 ¶ 171 173 W4251281504.pdf 0 6 title 0.97664773 Notice of Republication 173 197 W4251281504.pdf 0 7 separator 0.97839344 ¶ 197 199 W4251281504.pdf 0 8 text 0.9550834 "This article was republished on August 1, 2016, to correct errors that were introduced during the typesetting process: in several places throughout the article the αwas omitted from α- MSH. The publisher apologizes for the error. Please download this article again to view the cor-rect version. The originally published, uncorrected article and the republished, corrected article are provided here for reference." 199 618 W4251281504.pdf 0 9 separator 0.9962161 ¶ 618 620 W4251281504.pdf 0 10 title 0.9803567 Supporting Information 620 643 W4251281504.pdf 0 11 separator 0.9914462 ¶ 643 645 W4251281504.pdf 0 12 bibliography 0.41688108 S1 File. 645 654 W4251281504.pdf 0 13 table 0.42385963 Originally published, uncorrected 654 688 W4251281504.pdf 0 14 bibliography 0.34778935 article. ¶ 688 699 W4251281504.pdf 0 15 table 0.4175507 (PDF) 699 705 W4251281504.pdf 0 16 separator 0.6853823 ¶ 705 707 W4251281504.pdf 0 17 table 0.49956876 "S2 File. Republished corrected article. (PDF)" 707 755 W4251281504.pdf 0 18 separator 0.99593055 ¶ 755 757 W4251281504.pdf 0 19 title 0.42305854 Reference 757 767 W4251281504.pdf 0 20 separator 0.9869714 ¶ 767 769 W4251281504.pdf 0 21 bibliography 0.9923114 "1. Møller CL, Kj øbsted R, Enriori PJ, Jensen TE, Garcia-Rudaz C, Litwak SA, et al. (2016) α-MSH Stimu- lates Glucose Uptake in Mouse Muscle and Phosphorylates Rab-GTPase-Activating Protein TBC1D1 Independently of AMPK. PLoS ONE 11(7): e0157027. doi: 10.1371/journal.pone.0157027 PMID: 27467141" 769 1070 W4251281504.pdf 0 22 separator 0.7904742 ¶ 1070 1072 W4251281504.pdf 0 23 paratext 0.9577288 "PLOS ONE | DOI:10.1371/journal.pone.0161047 August 8, 2016 1/1a11111 OPEN ACCESS" 1072 1155 W4251281504.pdf 0 24 separator 0.93459165 ¶ 1155 1157 W4251281504.pdf 0 25 paratext 0.8885175 "Citation: ThePLOS ONE Staff (2016) Correction: α- MSH Stimulates Glucose Uptake in Mouse Muscleand Phosphorylates Rab-GTPase-Activating ProteinTBC1D1 Independently of AMPK. PLoS ONE 11(8):e0161047. doi:10.1371/journal.pone.0161047" 1157 1390 W4251281504.pdf 0 26 separator 0.5406809 ¶ 1390 1392 W4251281504.pdf 0 27 paratext 0.9600344 Published: August 8, 2016 1392 1418 W4251281504.pdf 0 28 separator 0.74801356 ¶ 1418 1420 W4251281504.pdf 0 29 paratext 0.9542411 "Copyright: © 2016 The PLOS ONE Staff. This is an open access article distributed under the terms of theCreative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited." 1420 1696 W4251281504.pdf 0 0 paratext 0.948097 "JURNAL NERS http://e -journal.unair.ac.id/JNERS | 47 risk of heart disease, from the lowest score of -3 to -5 and from the median value of 1 to 0.5." 0 156 W2886022284.pdf 5 1 separator 0.9943123 ¶ 158 160 W2886022284.pdf 5 2 text 0.9995772 "The results listed in Table 9 focused on the difference in the risk score of heart disease in the control group in relation to the three measurements obtained a p -value of 0.098. Statistically, this shows that there is no significant difference between the first, second, and third measurements. However, when viewed from the median value achieved at the beginning of th e measurement, it showed that the risk of heart disease increased from the score of 1.5 to a score of 2 at the end of the measurement period. In addition, the minimum score also increased from -4 to -3. This suggests that the control group respondents tend to have an increased risk of developing heart disease at the end of the measurement period." 160 925 W2886022284.pdf 5 3 separator 0.99443704 ¶ 927 929 W2886022284.pdf 5 4 title 0.9908276 DISCUSSION 929 940 W2886022284.pdf 5 5 separator 0.99635744 ¶ 942 944 W2886022284.pdf 5 6 text 0.9997614 "The behaviour of a person living a healthy lifestyle is influenced by several factors, one of which is the knowledge and understanding possessed by a pe rson (Mindy & Alyson, 2015). Therefore, to improve one's knowledge, it can be provided through health education. Health education activities aim to increase one's knowledge and understanding so that they will be able to transform their behaviour into a hea lthier one (Marianne et al, 2001). There are many methods used in health education, one of which is Peer Health Education. Peer Health Education involves a person who is considered to be able influence the community around them. By using the Peer Health Education method, it is hoped that the communities around them will find it easier to understand and implement the knowledge that they have acquired (Duncanson et al, 2014)." 944 1832 W2886022284.pdf 5 7 separator 0.95048726 ¶ 1834 1836 W2886022284.pdf 5 8 text 0.9997528 "This is in accordance with the results of the research as shown in Table 1, which shows that Peer Health Education can increase the knowledge of the respondents on what makes a healthy lifestyle to prevent heart disease (p -value 0,004). It also showed that for the respondents who did not get Peer Health Education, their knowledge about utilising a healthy lifestyle to prevent heart disease tended to show no difference between the first measurements and the second measurement (p -value 0.172). So, from the analysis of both groups, it showed that there is a difference in the knowledge abou t using healthy lifestyles to prevent heart disease between the groups who underwent Peer Health Education and those who did not get Peer Health Education access (p -value 0.034). Peer Health Education is an effective method in health education that is used to provide health information to a group of people with special characteristics, with the aim of achieving certain knowledge and skills used to achieve a health goal. A Peer Health Educator is also able to motivate and facilitate members of their group to behave healthily in accordance with the expected goals. A Peer Health Educator is also able to share information in an applicable, practical and appealing way to the audience and therefore it is often easier for them to produce behavioural changes (Duncan son et al, 2014)." 1836 3302 W2886022284.pdf 5 9 separator 0.9863144 ¶ 3304 3306 W2886022284.pdf 5 10 text 0.9997346 "Good knowledge, an understanding of the community and an awareness of the attitude to healthy lifestyles in order to prevent heart disease will be able to affect their behaviour in daily life. The results of the research in Table 3 shows that Peer Health Education can influence the consumption pattern of sweet foods in the community group who are at risk of heart disease (p -value 0.011). In the first measurements, the Peer Health Education action was given, and the pattern of the excessive consumption of sweet foods was more than once per day for as many as 39.3% of respondents. At the end of the measurements, the number decreased to 10.7% of the respondents. This shows that the pattern of the excessive consumption of sweet foods is one of the risk factors for heart disease. Consuming excess sweet foods will increase the risk of increased blood pressure. The results of another study indicate that there is a significant relationship between the pattern of consumption of sweet foods with the o ccurrence of increased systolic blood pressure in patients with hypertension (Fikriana, 2016). This happens because the consumption of excessive sweet foods will cause the levels of glucose and fructose in the blood to increase, which will affect the metab olism of a person's body, causing damage and the homeostasis of the blood vessel walls, affecting insulin disturbance in the body as well as increasing the occurrence of the lipogenesis process (Siervo et al, 2013)." 3306 4872 W2886022284.pdf 5 11 separator 0.9916184 ¶ 4874 4876 W2886022284.pdf 5 12 text 0.9994344 "Table 6 shows that there was a differenc e in blood pressure before treatment and after treatment (p - value 0.010). Before the treatment was obtained, the number of respondents who had normal blood pressure was as many as 32.1%. After treatment, there was an increase in the number of respondents who had normal blood pressure, up to 46.4%. The respondents who had not had the treatment had blood pressure that fit the classification of hypertension stage 2, which decreased the number of respondents from the previous 14.3% to 7.1%. This shows that the Peer Health Educator can motivate the respondents to control their blood pressure. The results of this study are in line with the research conducted by Mindy & Alyson (2015), which states that knowledge will affect a person's ability to control his or her blood pressure." 4876 5750 W2886022284.pdf 5 13 separator 0.9781266 ¶ 5752 5754 W2886022284.pdf 5 14 text 0.9996672 "The pattern of the excessive consumption of fatty foods, stress/anxiety and a lack of exercise are also risk factors that can cause heart disease. However, the results of this study indicate that there is no difference in the behaviour pattern of fast food consumption (p -value 0.078), physical activity (p - value 0.268), and stress/anxiety (p -value 0.441) in the group receiving Peer Health Education. This is in line with the results of the study in Table 6, which shows no difference in blood cholesterol level s before treatment and after treatment (p -value 0.291). The increased knowledge obtained by the respondents does not directly affect the behaviour of the" 5754 6462 W2886022284.pdf 5 0 paratext 0.9842322 ¶ https://journal.utripoli.edu.ly/index.php/Alqalam/index eISSN 2707 -7179 1 77 W4393131461.pdf 7 1 separator 0.8425321 "¶ ¶" 79 89 W4393131461.pdf 7 2 paratext 0.96021205 Alfituri et al. Alq J Med App Sci. 2024;7( 2):213-221 220 89 150 W4393131461.pdf 7 3 separator 0.99137425 ¶ 151 153 W4393131461.pdf 7 4 bibliography 0.956505 "5. WHO. Coronavirus disease (COVID -19): How is it transmitted? [Internet]. 2021 [cited 2023 Aug 19]. 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Available from: https:/ /www.cdc.gov/coronavirus/2019 -ncov/vaccines/different -vaccines/how -they-work.html" 1324 1525 W4393131461.pdf 7 17 separator 0.9557073 ¶ 1528 1530 W4393131461.pdf 7 18 bibliography 0.994862 "12. Mayoclinic.org. Different types of COVID -19 vaccines: How they work [Internet]. 2023 [cited 2023 Aug 10]. Available from: https://www.mayoclinic.org/diseases -conditions/coronavirus/in -depth/different -types -of-covid -19-vaccines/art - 20506465" 1530 1787 W4393131461.pdf 7 19 separator 0.98356974 ¶ 1790 1792 W4393131461.pdf 7 20 bibliography 0.9972548 "13. WHO. COVID 19 VACCINE [Internet]. 2023 [cited 2023 Aug 19]. Available from: https://covid19.who.int/region/emro/country/ly" 1792 1923 W4393131461.pdf 7 21 separator 0.9492549 ¶ 1926 1928 W4393131461.pdf 7 22 bibliography 0.9973148 "14. Seed S. Complications Coronavirus Can Cause [Internet]. 2021 [cited 2023 Aug 10]. Available from: https://www.webmd.com/covid/coronavirus -complications#1" 1928 2090 W4393131461.pdf 7 23 separator 0.97546047 ¶ 2093 2095 W4393131461.pdf 7 24 bibliography 0.99785656 "15. Suvvari TK, Kutikuppala LVS, Tsagkaris C, Corriero AC, Kandi V. Post -COVID -19 complications: Multisystemic approach. J Med Virol. 2021;93(12):6451 –5." 2095 2255 W4393131461.pdf 7 25 separator 0.9699222 ¶ 2257 2259 W4393131461.pdf 7 26 bibliography 0.9976738 "16. Hasabo EA, Ayyad FA, Alam Eldeen SAM, Noureldaim MK, Abdallah TA, Ahmed YT, et al. Clinical manifestations, complications, and outcomes of patients with COVID -19 in Sudan: a multicenter observational study. Trop Med Health. 2021;49(1):91." 2259 2509 W4393131461.pdf 7 27 separator 0.97777903 ¶ 2511 2513 W4393131461.pdf 7 28 bibliography 0.9980705 "17. Ramanathan K , Antognini D, Combes A, Paden M, Zakhary B, Ogino M, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(20):497 –506." 2513 2709 W4393131461.pdf 7 29 separator 0.96643883 ¶ 2711 2713 W4393131461.pdf 7 30 bibliography 0.9978494 "18. Poudel R, Daniels LB, DeFilippis AP, Hamburg NM, Khan Y, Keith RJ, et al. Smokin g is associated with increased risk of cardiovascular events, disease severity, and mortality among patients hospitalized for SARS -CoV -2 infections. PLoS One. 2022;17(7 July):1 –14." 2713 2988 W4393131461.pdf 7 31 separator 0.9566463 ¶ 2990 2992 W4393131461.pdf 7 32 bibliography 0.99788475 19. Ma RCW, Holt RIG. COVID -19 and diabetes. Diabet Med. 2020;37(5):723 –5. 2992 3069 W4393131461.pdf 7 33 separator 0.9561516 ¶ 3071 3073 W4393131461.pdf 7 34 bibliography 0.9979513 "20. Haider T, Abidi SRZ, Fatima M, Zafar A, Siddiqui RQU, Khan W, et al. The Prevalence of Side Effects of Sinopharm COVID -19 Vaccine: An Experience From Pakistan. Cureus. 2023;15(4):2 –8." 3073 3266 W4393131461.pdf 7 35 separator 0.96243376 ¶ 3268 3270 W4393131461.pdf 7 36 bibliography 0.99764764 "21. Kim EJ, Yoo SJ. Pulmonary Embolism after Vaccination with the COVID -19 Va ccine (Pfizer, BNT162b2): A Case Report. Vaccines. 2023;11(6):1 –9." 3270 3420 W4393131461.pdf 7 37 separator 0.9787327 ¶ 3422 3424 W4393131461.pdf 7 38 bibliography 0.9979671 "22. SeyedAlinaghi SA, Afsahi AM, MohsseniPour M, Behnezhad F, Salehi MA, Barzegary A, et al. Late Complications of COVID -19; a Systematic Review of Current Evidence. Arch Acad Emerg Med. 2020; 9(1):e14." 3424 3631 W4393131461.pdf 7 39 separator 0.71988475 "¶ " 3633 3642 W4393131461.pdf 7 40 paratext 0.38267186 "¶ ¶ ¶ ¶ ¶" 3642 3675 W4393131461.pdf 7 41 separator 0.7592868 ¶ ¶ 3677 3683 W4393131461.pdf 7 0 paratext 0.98935556 www.nature.com/scientificreports/2 0 34 W2896897117.pdf 1 1 separator 0.67481625 34 35 W2896897117.pdf 1 2 paratext 0.9415486 ¶ Scientific REPORTS | (2018) 8:15545 | DOI:10.1038/s41598-018-33998-4a 35 110 W2896897117.pdf 1 3 text 0.588336 pproach has been initiated with in vitro systems by the National Cancer Institute (N 110 195 W2896897117.pdf 1 4 paratext 0.34684703 CI 195 197 W2896897117.pdf 1 5 text 0.97685176 ") in Bethesda, Maryland (USA) and is pursued by a growing number of public and private laboratories around the world17. Although extensive research has been performed under in vitro conditions concerning drug response and many of the mechanisms have been characterized, translating this to the clinic still represents a major conceptual and techni- cal challenge. Hence, an additional approach that identifies drug sensitivity could significantly advance the clini-cal management of tumors such as OSCC. Analyzing the expression patterns of genes related to drug response in tumor samples along with evaluating drug response at the cellular level using cell-based assays will assist in drug selection in a personalized manner in order to manage OSCC." 197 965 W2896897117.pdf 1 6 separator 0.9839276 ¶ 965 967 W2896897117.pdf 1 7 text 0.9945096 "The BCL-2 family proteins are known to control the apoptosis and classified into pro-apoptotic and anti-apoptotic members 18. Recently, a new functional assay, BCL2-homology domain 3 (BH3) profiling, was reported, and this profiling could predict drug sensitivity in primary tumor samples19. The BH3 profiling is a potentially powerful technique to measure early changes in net pro-apoptotic signaling in mitochondria (“apop-totic priming”) induced by chemotherapeutic agents" 967 1454 W2896897117.pdf 1 8 separator 0.9571924 ¶ 1454 1456 W2896897117.pdf 1 9 text 0.92573076 "14. BH3 profiling interrogates the BCL-2 family of proteins that regulates commitment to the mitochondrial pathway of apoptosis in response to most chemotherapeutic agents " 1456 1632 W2896897117.pdf 1 10 separator 0.5445787 ¶ 1632 1633 W2896897117.pdf 1 11 text 0.9962554 "20. BH3 peptides are convenient, titratable components that can be exploited to systematically study mito- chondrial readiness to undergo apoptosis21. Thus, BH3 profiling based on the drug’s ability to initiate apoptosis priming can be used to predict the cytotoxic response of cancers to chemotherapeutics before chemotherapy is administered." 1633 1982 W2896897117.pdf 1 12 separator 0.99067867 ¶ 1982 1984 W2896897117.pdf 1 13 text 0.99967706 "There is a significant lack of scientific investigation correlating expression pattern of genes involved in drug response with cell-based experiments to precisely forecast tumor sensitivity towards anticancer drugs. To sat - isfy this unmet need, we correlated certain drug-response related gene expression patterns with the % apoptotic priming in cancer cells isolated from a cohort of OSCC samples. In this study, we employed a qRT-PCR array to study the expression of certain multidrug resistance (MDR)-linked genes and correlated this with the results of" 1984 2548 W2896897117.pdf 1 14 separator 0.98842186 ¶ 2549 2551 W2896897117.pdf 1 15 caption 0.9961953 "Figure 1. Expression levels of drug response genes in 31 OSCC samples. (A) The mRNA expression pattern of 11 drug response-linked genes. The total mRNA was isolated from fresh tumor tissues and were detected using custom PCR array following the manufacturer’s instructions. The clustergram results of three independent experiments were analyzed using the SA Biosciences online tool. (B) Venn diagram showed the gene expression pattern of drug resistance genes in tumor samples. Samples 9 and 10 overexpress most of the drug response- linked genes." 2551 3104 W2896897117.pdf 1 0 text 0.9574811 "ristische Verhalten wie die 4.5-Dinitrodiphenylenglykolsiiure. Man er- halt eunachst eine rothgelbe Losung, die beim Erwiirmen tief purpur- roth wird." 0 156 W1989842774.pdf 13 1 separator 0.99141014 ¶ 157 159 W1989842774.pdf 13 2 table 0.6475762 "Ozim des 4..~-L)i/,it,.o~tlitorenons. Kryjtsllisirt ails Alkohol in braungelben Nadeln, die bei 267-2680 schmelzen." 159 278 W1989842774.pdf 13 3 separator 0.93408823 ¶ 279 281 W1989842774.pdf 13 4 table 0.94904214 0.1382 g Sbst.: 18.2 ccm N t214 747 mm). 281 322 W1989842774.pdf 13 5 separator 0.8997337 ¶ 323 325 W1989842774.pdf 13 6 table 0.9174419 "Ptienjlliydraaon des 4.5 . Uinitro$uorenona. 13ildet ziegelrothe Nsdelchen, 0.1376 g Sbst.: 19.4 ccm N (21°, 73G mm)." 325 446 W1989842774.pdf 13 7 separator 0.520975 447 448 W1989842774.pdf 13 8 table 0.95563954 ¶ CI~HI~O,N,. Ber. N 15.55. Gef. N 15.54. 448 489 W1989842774.pdf 13 9 separator 0.9695765 ¶ 490 492 W1989842774.pdf 13 10 table 0.5243699 Scjnicnr6 492 502 W1989842774.pdf 13 11 text 0.4902791 azon des 5.5 Dini 502 519 W1989842774.pdf 13 12 table 0.4973522 ho-A 519 523 W1989842774.pdf 13 13 text 0.607731 "uorenons. Durch Kochen des Ketons mit Semicarbazi" 523 575 W1989842774.pdf 13 14 table 0.5137964 d 575 576 W1989842774.pdf 13 15 text 0.63901114 chlorhydrat ebenfalls in alkoholischer Suspension dargestellt: 576 638 W1989842774.pdf 13 16 separator 0.4120248 639 640 W1989842774.pdf 13 17 table 0.76536024 ¶ bildet hellgelbe Nadeln, die bei 2880 unter Zersetzung schmelzen. CI3H7O5N3. Ber. N 14.73. Gef. N 11.73. 640 746 W1989842774.pdf 13 18 separator 0.5194945 ¶ 747 749 W1989842774.pdf 13 19 table 0.6683223 aelche bei 2-1 lo unter Zersetziing echmelzen. 749 796 W1989842774.pdf 13 20 separator 0.6109016 ¶ 797 799 W1989842774.pdf 13 21 table 0.955999 "0.1378 g Sbst.: 26.6 ccm N (220, 740 mm). CIdHgOsNs. Ber. N 21.40. Gef. N 21.26." 799 883 W1989842774.pdf 13 22 separator 0.9854853 ¶ 884 886 W1989842774.pdf 13 23 table 0.40265125 5. 886 889 W1989842774.pdf 13 24 title 0.5569063 Flnorenabkommlinge, erhalten aus 2-Bro1n-phenanthrenchinon 889 948 W1989842774.pdf 13 25 table 0.41223136 . 948 949 W1989842774.pdf 13 26 separator 0.9663101 ¶ 950 952 W1989842774.pdf 13 27 table 0.49153742 HO COOH 952 960 W1989842774.pdf 13 28 separator 0.9504403 ¶ 961 963 W1989842774.pdf 13 29 text 0.9945602 "Das 2-Bromphenanthrenchinon') wird von 10-procentiger Kali- Iauge bei gew6hnlicher Temperatur nicht angegriffen. Eret beim Er- wiirmen auf 80 -90° erfolgt Bildung der 2-Bromdiphenylenglpkoleaure und zwar in bemerkenswerth glatter Weise. Man erwiirmt 2 g reiues 2-Bromphenanthrenchinon rnit 200 ccm 10-procentiger Kalilauge auf 80-900, bis eine fast klare Liisung vorliegta)., filtrirt dorch Glaswolle ond iibersattigt das abgekiihlte Filtrat rnit verdiinnter Schwefeleaure. Dabei scheidet sich die 2-Bromdiphenylenglykoleaure in weissen Na- deln ab, welche wrgftiltig ausgewaschen nnd im Vacuumexsiccator ge- trocknet werden." 963 1616 W1989842774.pdf 13 30 separator 0.9706584 ¶ 1617 1619 W1989842774.pdf 13 31 text 0.7940819 "0.1594 g Sbst.: 0.3164 g Cog, 0.0440 g HsO. - 0.3553 g Sbst. erforderteo nach dem Vergliihen mit Kalk 11.55 ccm 'il0-n. Silbernitratlosung." 1619 1762 W1989842774.pdf 13 32 separator 0.93642557 ¶ 1763 1765 W1989842774.pdf 13 33 table 0.9457786 "CI(Hg03Br. Ber. C 55.08, H 2.95, Br 26.23. Gef. a 54.79, >) 3.OG, D 26.45." 1765 1843 W1989842774.pdf 13 34 separator 0.98033285 ¶ 1844 1846 W1989842774.pdf 13 35 text 0.97502834 "Die Same schmilzt bei 2130 unter Zersetzung. Sie 16sL sich sehr leicht in Aether, Aethyl-, Methyl-Alkohol, Eiseseig und Chloroform, schwer in Benzol und sehr schwer in kaltem Wasser. Ihre Losungen 1) Es wurde dargestellt nach den Angahen von J. Schmidt und E. 2) Etwas 2-Bromfluorenon, das sich hierbei bildet, bleibt ungelost." 1846 2186 W1989842774.pdf 13 36 bibliography 0.8474404 Junghans, diese Berichte 37, 3558 [1904]. 2186 2228 W1989842774.pdf 13 0 title 0.827846 Vanaken et al. Coherence, Social Support, Trauma Resilience 0 59 W3126511503.pdf 8 1 text 0.9994167 "¶ could be influenced by limitations in the design. First, we di d not include a separate manipulation check to control for the effectiveness of social support, apart from the psychological (STAI-S) and physiological (cortisol) stress measures. Loo king at the cortisol responses, stress continued to increase duri ng the whole experiment, which may be a sign that participants did not feel at ease and could have expected the stressful task to take place again later on in the experiment. This explanation would make sense keeping in mind that instructions in the MAST conceal the end of the experiment to be a short break, so participants could possibly be never fully relieved. Furtherm ore, the manipulation of social support may have been less credible or ineffective, given that both the traumatic event and the support was administered by one and the same person (the experimenter). On top of that, the experimenter changed roles from being a neutral to becoming either very empathetic or very apathetic, which may have increased overall distrust an d stress. As indicated earlier, research shows that the effecti veness of social support is dependent on many factors, one of which is the source of social support ( Barrera et al., 1981; Li et al., 2014; Nguyen et al., 2016; Alsubaie et al., 2019 ). Furthermore, research has indicated that unsupportive social interaction s have been more strongly associated with trauma responses tha n supportive social interactions (e.g., Ullman and Filipas, 2001; Andrews et al., 2003; DeCou et al., 2017 ). Future research could take this into consideration when setting up experiments. Fo r instance, comparing a condition in which participants can have a phone call to a (supportive) loved one after a traumatic event, to a condition in which they are only allowed to talk to an (unsupportive)experimenter,andtoacontrolconditioninwhi ch theycouldnottalktoanyotherperson,couldhelptodisentan gle this effect. In addition, while people who generally have high social support tend to have lower PTSD symptoms on any given day, average PTSD symptom severity does not seem to be associatedwithday-to-dayfluctuationsintheavailabilit yofsocial support(Dworkinetal.,2018 ).Forthepresentstudy,thiswould implythatthesocialsupportrightaftertheMASTtaskmayhave not been enough to buffer memory coherence or state anxiety, and rather that we would need a follow-up design to create a larger difference between conditions (more social support over time in supportive group, less social support over time in unsupportivegroup),inordertobeabletopickupdifferencesin posttraumaticresponses,likestateanxietyormemorycohere nce." 59 2789 W3126511503.pdf 8 2 separator 0.90862185 ¶ 2789 2791 W3126511503.pdf 8 3 text 0.9997047 "This would also be in line with research suggesting that attentive listeners can assist in the coherent co-construc tion of autobiographical narratives over time, and with research suggesting that memories eventually become reconstructio ns of previous(social)narrations( Bavelasetal.,2000;Pasupathi,2001; Pasupathi and Rich, 2005; Fivush, 2011 ). This would mean that multiple interactions with supportive, attentive listeners o ver time would be more helpful to protect memory coherence and mental health, in comparison with merely a single interventio n ofsupportrightafterthetraumaticevent." 2791 3404 W3126511503.pdf 8 4 separator 0.9627062 ¶ 3404 3406 W3126511503.pdf 8 5 text 0.9997643 "Finally, our exploratory analyses indicated that psychologi cal stress in the form of state anxiety and physiological stress in the form of cortisol did not run along similar patterns, contrary to our expectations and previous research ( Smeetset al., 2012 ). However, we did find that lower cortisol levels at baseline and after the first writing task could predict highe r coherence of the traumatic memory. Thus, it could be possible that those individuals who are better able to remain calm in situations that do arouse some people (e.g., participation in an experiment, thinking about important memories), are more likely to cope more adaptively with stressful situations late r on. This could be explained by the fact that the ability to remain calm renders the individual with sufficient free worki ng memory space, which is needed in order to process difficult events(KleinandBoals,2001 )." 3406 4324 W3126511503.pdf 8 6 separator 0.9797087 ¶ 4324 4326 W3126511503.pdf 8 7 text 0.9924945 "Besidestheaforementionedlimitationsinthedesign,anot her limitation can be noticed. Our sample consisted mostly of young, female, white students and was thus very homogeneous . Participants were also excluded based on current or previous psychopathology, which to some extent reduces our ability to generalize findings to clinical samples including individual s experiencing PTSD and other stress-related psychopathology." 4326 4758 W3126511503.pdf 8 8 separator 0.631845 ¶ 4758 4760 W3126511503.pdf 8 9 text 0.99962723 "Future research could take this into account by examining (sub-)clinical samples. Furthermore, it would be useful to asse ss participant’s prior traumatic experiences and examine these in relationtocopingabilitieswithnewtraumaticexperiences, since there is some evidence showing the impact of prior trauma on how new traumatic events are experienced ( Breslau et al., 2008; Schocketal.,2016 )." 4760 5166 W3126511503.pdf 8 10 separator 0.9787755 ¶ 5166 5168 W3126511503.pdf 8 11 text 0.9995113 "Concluding,inthisstudy,narrativesoftraumaticexperien ces were less coherent than narratives of turning point events." 5168 5287 W3126511503.pdf 8 12 separator 0.674364 5287 5288 W3126511503.pdf 8 13 text 0.99873114 "¶ However, contrary to our predictions, coherence, and, in particular, thematic coherence, related positively to anxiety levels. This possibly reflects a non-adaptive component in thematiccoherencethatcouldberelatedtoruminativeproces ses and unfinished attempts at meaning-making. Furthermore, coherence at baseline could not buffer against the impact of trauma on anxiety levels in this study. Contrary to our hypotheses, social support did not have the intended beneficial effects on coherence, neither on well-being. Multiple possible explanations are suggested. The source of support and the traumatic event was identical, namely the experimenter, who was unfamiliar to the participant as well as took on different roles over the experimental procedure, which likely reduced th e effectiveness the credibility of the social support. Also, stress levels for all participants were constantly increasing over th e procedure,asreflectedbyrisinglevelsofcortisol.Thiscould have overruled the effect of social support on coherence and well- being overall. Nonetheless, lower cortisol levels at baselin e and after writing about the turning point memory predicted higher coherence in the trauma narratives. This may point out that the ability to remain calm in difficult situations does relate to the ability to cope adaptively with future difficult experiences ." 5288 6676 W3126511503.pdf 8 14 separator 0.7548037 ¶ 6676 6678 W3126511503.pdf 8 15 text 0.994455 "Further research on the relations between narrative cohere nce, socialsupport,andtraumaresilienceisrecommended." 6678 6792 W3126511503.pdf 8 16 separator 0.98998344 ¶ 6792 6794 W3126511503.pdf 8 17 title 0.9909223 DATA AVAILABILITY STATEMENT 6794 6822 W3126511503.pdf 8 18 separator 0.97199345 ¶ 6822 6824 W3126511503.pdf 8 19 text 0.9973146 "The dataset generated for this study can be found in online repositories (Open Science Framework): doi:10.17605/OSF.IO/3H7QM." 6824 6954 W3126511503.pdf 8 20 separator 0.9704089 ¶ 6954 6956 W3126511503.pdf 8 21 paratext 0.98420763 Frontiers in Psychology | www.frontiersin.org 9 February 2021 | Volume 12 | Article 558044 6956 7047 W3126511503.pdf 8 0 text 0.99843013 "treatment for patients with OCD. This collaborative initiative also aims to enhance the validity and reliability of researchresults provided by different facilities and countries. This initiative is similar to those that have been implemented to establish stand- ards of care for other mental health issues, such as diagnosticassessment and treatment of people with dementia (MSNAP 2012) or the administration of electroconvulsive therapy (ECTAS 2012)." 0 462 W2472797563.pdf 2 1 separator 0.99482536 ¶ 462 464 W2472797563.pdf 2 2 title 0.9832555 Methods 464 472 W2472797563.pdf 2 3 separator 0.9947407 ¶ 472 474 W2472797563.pdf 2 4 text 0.9994132 "Standards of care were selected through a highly consensual pro- cedure that gathered a large number of opinions and points of view. This was done in an interactive and iterative way, enablingconsiderable feedback to be obtained from experienced therapistsin the field of OCD. Consensus was not based only on the experts’ opinions, but on widely used clinical practice guidelines in OCD, also. Examples of these guidelines have been developed by thefollowing associations and institutions: the National Institute for Health and Care Excellence (NICE guideline 2005 ), the American Psychiatric Association (APA guideline 2013 ), the British Association for Psychopharmacology (Baldwin et al. 2014 ), American Academy of Child and Adolescent Psychiatry (AACAP guideline 2012 ), the World Federation of Societies of Biological Psychiatry (Bandelowet al. 2012 ) and the Cape Town Consensus Statement (Stein 2007 )." 474 1403 W2472797563.pdf 2 5 separator 0.9931694 ¶ 1403 1405 W2472797563.pdf 2 6 text 0.9987909 "The process began with the call for applications to participate in the working groups (child and adult) in May 2013. Applications were received (from ICOCS members and non-members) and threegroups were established: the Steering Committee (formed by 13 board members, not included in the working groups), the Child OCD Centres Working Group and the Adult OCD Centres WorkingGroup. The working groups of the ICOCS Credentialing Task Force included leaders and highly experienced practitioners in OCD (including psychiatrists, psychologists and mental health nurses)from many different countries: Turkey, South Africa, United Kingdom, Sweden, United States of America, Israel, the Netherlands, Bulgaria, Canada, Japan, Argentina, Hungary, Braziland Australia." 1405 2178 W2472797563.pdf 2 7 separator 0.97802323 ¶ 2178 2180 W2472797563.pdf 2 8 text 0.97010124 "After a review of similar initiatives, a survey containing a com- prehensive list of possible standards was sent to all members of the working groups. The objective was to decide which itemsshould be included as standards. The working members had to rate the possible standards according to the following: (0): should not be included" 2180 2522 W2472797563.pdf 2 9 table 0.5809887 ¶ 2522 2524 W2472797563.pdf 2 10 text 0.63651794 (1): the standard is not essential, 2524 2560 W2472797563.pdf 2 11 table 0.52923536 but 2560 2564 W2472797563.pdf 2 12 text 0.59099436 may be pertinent 2564 2581 W2472797563.pdf 2 13 table 0.51113975 for 2581 2585 W2472797563.pdf 2 14 text 0.49858838 an 2585 2588 W2472797563.pdf 2 15 table 0.62044173 "OCD unit ¶" 2588 2601 W2472797563.pdf 2 16 text 0.5857849 (2): the standard may be important for an O 2601 2645 W2472797563.pdf 2 17 table 0.6033529 CD unit ¶ 2645 2654 W2472797563.pdf 2 18 text 0.5902701 (3): the standard is definitely necessary for an O 2654 2705 W2472797563.pdf 2 19 table 0.500381 CD 2705 2707 W2472797563.pdf 2 20 text 0.52238566 unit 2707 2712 W2472797563.pdf 2 21 separator 0.9523256 ¶ 2712 2714 W2472797563.pdf 2 22 text 0.98850983 The standards were grouped into the following areas: 2714 2767 W2472797563.pdf 2 23 separator 0.73914605 ¶ 2767 2769 W2472797563.pdf 2 24 text 0.7803694 "I. Resources II. Procedures and assessmentIII. Management and follow-upIV. Quality indicators." 2769 2866 W2472797563.pdf 2 25 separator 0.986786 ¶ 2866 2868 W2472797563.pdf 2 26 text 0.9940533 "When all the responses had been received, a list with the selected standards was again sent to the members of the working groups, and two teleconferences were held shortly after (with the adult andchild working groups). In this second stage, the groups were askedto distribute the standards on the following two different levels: a. Recommended standards, considered key elements for an OCD unit (i.e., those that an accredited centre would beexpected to meet)b. Excellence standards (i.e., those that an excellent service should meet or criteria that, while not essential for an OCDunit, would bring higher quality to the unit)." 2868 3508 W2472797563.pdf 2 27 separator 0.92182934 ¶ 3508 3510 W2472797563.pdf 2 28 text 0.9990939 "Once this information had been received, a Reference Group also assessed the proposed standards. Thereafter, the proposal was sent to the Steering Committee, which produced an overviewof all the feedback. The final proposal was presented at the ICOCS9th Scientific Meeting, held in Berlin on 22 October 2014." 3510 3823 W2472797563.pdf 2 29 separator 0.9967977 ¶ 3823 3825 W2472797563.pdf 2 30 title 0.96880776 Results 3825 3833 W2472797563.pdf 2 31 separator 0.9417325 ¶ 3833 3835 W2472797563.pdf 2 32 title 0.9258752 Resources 3835 3845 W2472797563.pdf 2 33 separator 0.75256246 ¶ 3845 3847 W2472797563.pdf 2 34 title 0.7348281 Facilities 3847 3858 W2472797563.pdf 2 35 separator 0.93968165 ¶ 3858 3860 W2472797563.pdf 2 36 text 0.9981871 "The unit provides suitable facilities in an environment that is appropriate to the needs of people with OCD. The service offers places and resources for staff to carry out their duties effectively." 3860 4062 W2472797563.pdf 2 37 separator 0.9586196 ¶ 4062 4064 W2472797563.pdf 2 38 text 0.9370638 "Recommendable 1. To have private consultation rooms 2. Availability of a psychiatric inpatient ward or day treatment facilities (not necessarily specific for OCD, may be a generalpsychiatric inpatient ward) with specific knowledge of OCD treatment for severe patients or for specific OCD treatments." 4064 4372 W2472797563.pdf 2 39 separator 0.9928739 ¶ 4372 4374 W2472797563.pdf 2 40 text 0.45811382 1 4374 4376 W2472797563.pdf 2 41 separator 0.86188173 ¶ 4376 4378 W2472797563.pdf 2 42 title 0.77948403 Excellence 4378 4389 W2472797563.pdf 2 43 separator 0.80452365 ¶ 4389 4391 W2472797563.pdf 2 44 text 0.6381635 1. Consultation and counselling rooms large enough for family 4391 4453 W2472797563.pdf 2 45 table 0.71233535 ¶ 4453 4455 W2472797563.pdf 2 46 text 0.607604 meeting 4455 4463 W2472797563.pdf 2 47 table 0.6223393 "s 2." 4463 4469 W2472797563.pdf 2 48 text 0.542471 Group therapy 4469 4483 W2472797563.pdf 2 49 table 0.6174624 "room 3." 4483 4493 W2472797563.pdf 2 50 text 0.6083505 Access to facilities for showering/bathing 4493 4536 W2472797563.pdf 2 51 table 0.5716074 , 4536 4537 W2472797563.pdf 2 52 text 0.5085425 for 4537 4541 W2472797563.pdf 2 53 table 0.5304234 practis 4541 4549 W2472797563.pdf 2 54 text 0.5216086 ing 4549 4552 W2472797563.pdf 2 55 table 0.66466844 "¶ behavioural exercises 4." 4552 4581 W2472797563.pdf 2 56 text 0.5578955 Computer and internet access 4581 4610 W2472797563.pdf 2 57 table 0.56301093 for therapeutic 4610 4626 W2472797563.pdf 2 58 text 0.53269994 4626 4627 W2472797563.pdf 2 59 table 0.5757466 "exposure of patients ¶" 4627 4651 W2472797563.pdf 2 60 text 0.7422288 5. Access to kitchen facilities so as to practise preparing food 4651 4716 W2472797563.pdf 2 61 separator 0.99422455 ¶ 4716 4718 W2472797563.pdf 2 62 title 0.9843132 Child units 4718 4730 W2472797563.pdf 2 63 separator 0.9829327 ¶ 4730 4732 W2472797563.pdf 2 64 text 0.998722 "Availability of or integration with a paediatric general medical ser- vice (given the frequent comorbidity and, in particular, the poten-tial role of a post-infectious autoimmune basis in OCDpathophysiology)." 4732 4943 W2472797563.pdf 2 65 separator 0.9947244 ¶ 4943 4945 W2472797563.pdf 2 66 title 0.9826051 Human resources 4945 4961 W2472797563.pdf 2 67 separator 0.9821929 ¶ 4961 4963 W2472797563.pdf 2 68 text 0.99915326 "Skilled and qualified staff are essential to ensure that patients obtain the appropriate treatment in accordance with state-of-the- art knowledge. The staff members involved in the assessment and treatment of patients work as a multidisciplinary team and dis-cuss relevant clinical matters. Staff members are properly trainedfor their job and their continuing professional development is facili- tated. The roles and responsibilities of team members are defined." 4963 5434 W2472797563.pdf 2 69 separator 0.9940078 ¶ 5434 5436 W2472797563.pdf 2 70 title 0.7616914 Recommendable 5436 5450 W2472797563.pdf 2 71 separator 0.83718014 ¶ 5450 5452 W2472797563.pdf 2 72 table 0.4830741 1. 5452 5455 W2472797563.pdf 2 73 text 0.48587343 The unit has at 5455 5471 W2472797563.pdf 2 74 table 0.5540828 least 5471 5477 W2472797563.pdf 2 75 text 0.47136858 one 5477 5481 W2472797563.pdf 2 76 table 0.55600667 "staff psychiatrist with clinical experi- ence and training in the following: /C15 The diagnosis, background and treatment of OCD: /C15 Psychopathology of ob" 5481 5644 W2472797563.pdf 2 77 text 0.46124786 sessions 5644 5652 W2472797563.pdf 2 78 table 0.43293688 "and compulsions and the assessment of " 5652 5693 W2472797563.pdf 2 79 text 0.34099373 insight 5693 5700 W2472797563.pdf 2 80 table 0.6583308 ". /C15 Main clinical dimensions/subtypes of OCD. /C15 Diagnostic criteria for OCD. /C15 The diagnosis, background and treatment of OCD spec- trum and related disorders." 5700 5876 W2472797563.pdf 2 81 paratext 0.93719846 INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE 205 5876 5936 W2472797563.pdf 2 0 paratext 0.9880106 RattanakulandLenbury AdvancesinDifferenceEquations (2017) 2017:162 Page9of14 0 76 W2624385668.pdf 8 1 separator 0.9949805 ¶ 76 78 W2624385668.pdf 8 2 text 0.9981184 "ofboundreceptorsofvarioustypesinturnsleadtodifferentlevelsofextracellularandin- tracellularcalciumaccordingtoequations( )and(),respectively.Thus,excessivelyhigh orlowcalciumlevelisbroughtbacktoanormallevelbysuchPTHfeedbackmechanism." 78 316 W2624385668.pdf 8 3 separator 0.6469481 ¶ 316 318 W2624385668.pdf 8 4 text 0.9982529 "We refer the readers to [ ]a n d[] for the detail of the manner in which the receptors are assumed to move toward neighboring receptors to form dimers or oligomers, after whichtheirbindingaffinityisimproved.Here,weshowthediagraminFigure toexplain how a receptor moves closer to its neighboring receptors that are bound to form dimersoroligomers.Iftherearemorethanoneboundreceptorinitsneighborhood,oneofsuchreceptorsischosenatrandomtobetheoneapproached." 318 778 W2624385668.pdf 8 5 separator 0.9970262 ¶ 778 780 W2624385668.pdf 8 6 title 0.99132246 4 Simulationresultsanddiscussion 780 813 W2624385668.pdf 8 7 separator 0.9964298 ¶ 813 815 W2624385668.pdf 8 8 text 0.99943227 "We discovered that the simulated time series from all simulation runs are not noticeablydifferentfromeachother,andtherefore,wesh owinthefollowingfigurestheaverageover  runs for each construct. In Figure the simulated time series of extracellularcalcium concentrationisshown,comparingthecasewhentraffickingisnotincorporatedintoourCA model ( ρ = .), corresponding to the dashed curve, to the case that receptor traf- fickingisincorporated,whichisthesolidcurve.Weseethatbothcurvesexhibitdampedoscillations, while the receptor trafficking has the expected effect of significantly raisingthe extracellular fluid calcium concentration. Trafficking facilitates dimerization, whichincreases binding affinity of the receptors as has been reported by Wu et al.[]. It is necessary for receptors such as the vascular endothelial growth factor to form dimers tobecome activated. Before the receptor monomers bind with the growth factor, they are" 815 1752 W2624385668.pdf 8 9 separator 0.9466349 ¶ 1752 1754 W2624385668.pdf 8 10 caption 0.9685228 Figure3 Simulatedtimecoursesofextracellularcalciumconcentrationaboveitsequilibriumlevel 1754 1843 W2624385668.pdf 8 11 separator 0.59039724 ¶ 1843 1844 W2624385668.pdf 8 12 caption 0.9937831 Eb=2.4mmol/L,usingtheparametervaluesgiveninTables 1and3. 1844 1901 W2624385668.pdf 8 0 paratext 0.9901044 Viruses 2021 ,13, 1727 13 of 17 0 31 W3197883300.pdf 12 1 separator 0.9909049 ¶ 31 33 W3197883300.pdf 12 2 text 0.9871324 "only at 40 and 42C (Figure 8). These data corroborate an important role of W421 in conferring stability to virus particles." 33 160 W3197883300.pdf 12 3 separator 0.9910824 ¶ 160 162 W3197883300.pdf 12 4 caption 0.9957391 "Figure 8. Thermal stability of WT and mutants. Relative infectivity is expressed as percent of focus forming units (FFU) of the WT and mutants at 37C, 40C and 42C relative to the FFU of the WT control at 4C. Data are from at least three independent experiments; error bars represent the standard errors of the means (SEM). Asterisks indicate significant differences relative to the WT at the corresponding temperature (ANOVA and Dunnett’s multiple comparison test; *p< 0.05, **p< 0.01, *** p< 0.001)." 162 674 W3197883300.pdf 12 5 separator 0.9959736 ¶ 674 676 W3197883300.pdf 12 6 title 0.9904199 4. Discussion 676 690 W3197883300.pdf 12 7 separator 0.9960226 ¶ 690 692 W3197883300.pdf 12 8 text 0.99959934 "In this study, we investigated the role of the strictly conserved hydrophobic residue W421 in the CS element of the E-stem in the viral life cycle. Replacement of this residue by alanine or histidine impaired the secretion (and probably formation) of viral particles but had no apparent effect on their maturation, which involves acidic-pH-induced confor- mational changes and oligomeric reorganizations of prM and E to allow furin cleavage of prM in the TGN [ 16]. Likewise, the mutants were still capable of displaying those acidic- pH-triggered conformational changes that convert metastable E dimers into stable trimers and are necessary for membrane fusion during virus entry. These data are consistent with experiments that showed that the stem region is not involved in the stabilization of the E-trimer [ 13] and a study with a W421I SVP mutant of TBEV that was not only able to form stable post-fusion trimers, but also to fuse efficiently with liposomes [25]." 692 1681 W3197883300.pdf 12 9 separator 0.97988373 ¶ 1681 1683 W3197883300.pdf 12 10 text 0.99965334 "The evidence presented in this work suggests that the dramatically reduced specific infectivities of supernatants from mutant-infected cells are related to the strongly reduced stability of viral particles, resulting in a tendency for disintegration and reduced resistance to thermal inactivation. Our findings are in agreement with the loss of infectivity of dengue virus serotype 2 particles with a W420A mutation (W421A in TBEV) [ 12], although detailed experiments for identifying the reasons of this defect were not performed with the dengue mutant. As revealed by cryo-electron microscopy (EM) structure analyses, CS connects two helices of the stem as a loop, both in mature and immature particles [ 3–12,44]. In mosquito-borne flaviviruses, W421 constitutes the last residue of H2, whereas in TBEV it is the first residue of the loop (Figures 1B and 9). Studies resolving the structures of mature Zika, Spondweni and dengue serotype 2 viruses identified several residues (including W421, TBEV numbering) in the stem region of E as being part of lipid-binding pockets" 1683 2775 W3197883300.pdf 12 0 text 0.99554914 "the group submitted to CABG, two patients were submitted to thrombolytic therapy (TIMI score 3 and TIMI score 7) without mortality." 0 135 W2005036511.pdf 16 1 separator 0.9952396 ¶ 135 137 W2005036511.pdf 16 2 title 0.9595105 Conclusions 137 149 W2005036511.pdf 16 3 text 0.9992565 "The mortality was significantly higher in the group with clinical treatment ( P= 0.0189). The comparative study about the mortality of each group of TIMI score was not statistically significant: there was no correlation of TIMI score and mortality." 149 404 W2005036511.pdf 16 4 separator 0.99457407 ¶ 404 406 W2005036511.pdf 16 5 title 0.9555826 Nephrology 406 417 W2005036511.pdf 16 6 separator 0.6593434 ¶ 417 419 W2005036511.pdf 16 7 title 0.9001292 P37 419 423 W2005036511.pdf 16 8 separator 0.9825686 ¶ 423 425 W2005036511.pdf 16 9 title 0.8006015 "Does intensive insulin therapy really reduce the incidence of acute renal injury in critically ill patients? An analysis using the rifle criteria" 425 575 W2005036511.pdf 16 10 separator 0.9915347 ¶ 575 577 W2005036511.pdf 16 11 contact 0.7520948 "JRA Azevedo1, RP Azevedo1, LC Lucena2, NNR Costa1, WS Sousa2" 577 641 W2005036511.pdf 16 12 separator 0.92527485 ¶ 641 643 W2005036511.pdf 16 13 contact 0.9845892 "1Intensive Care Unit, Hospital São Domingos, São Luis – MA, Brazil; 2Intensive Care Unit, Hospital Dr Clementino Moura, São Luis – MA, Brazil" 643 789 W2005036511.pdf 16 14 separator 0.75117266 ¶ 789 791 W2005036511.pdf 16 15 paratext 0.98192966 Critical Care 2009, 13(Suppl 3): P37 (doi: 10.1186/cc7839) 791 850 W2005036511.pdf 16 16 separator 0.9945631 ¶ 850 852 W2005036511.pdf 16 17 title 0.7093509 Introduction 852 865 W2005036511.pdf 16 18 text 0.9982873 "In 2001, Van den Berghe and colleagues introduced the concept of strict glycemic control in the critically ill patient [1]. The impact of this new approach was particularly significant when the renal outcome of the patients was evaluated. While some subsequent studies corroborated Van den Berghe and colleagues’ results, others could not demonstrate any benefit of intensive insulin therapy on mortality and renal outcome. One of the diffi- culties in comparing the incidence of acute renal dysfunction is the lack of consensus about its definition. The RIFLE criteria, proposed in 2004 [2], had the objective of standardizing this definition." 865 1528 W2005036511.pdf 16 19 separator 0.99600345 ¶ 1528 1530 W2005036511.pdf 16 20 title 0.908431 Objective 1530 1540 W2005036511.pdf 16 21 text 0.97663856 "To compare the incidence and severity of acute kidney injury (AKI) in critically ill patients submitted to two different regi- mens of glycemic control, using the RIFLE criteria." 1540 1723 W2005036511.pdf 16 22 separator 0.99330866 ¶ 1723 1725 W2005036511.pdf 16 23 title 0.92414814 Methods 1725 1733 W2005036511.pdf 16 24 text 0.9976439 "Analysis of 228 patients who had been previously included in a prospective study, randomized to intensive insulin therapy (Group 1) or to a carbohydrate restrictive strategy (Group 2). The RIFLE criteria were established according to the creatinine values on the first day and the last day of the ICU stay, and the highest value obtained during this period. The renal outcome was evaluated through the comparison of the last RIFLE score obtained during the ICU stay and the RIFLE score at admission, and then classified as favorable, stable or unfavorable." 1733 2306 W2005036511.pdf 16 25 separator 0.99568534 ¶ 2306 2308 W2005036511.pdf 16 26 text 0.99827385 "Results The two groups were comparable regarding demographic data, APACHE III score and comorbidities. The median blood glucose levels were 132.6 mg/dl in Group 1 and 142.0 mg/dl in Group 2 ( P= 0.02). Hypoglycemia occurred in 20 (18.1%) patients in Group 1 and in five (4.2%) patients in Group 2 ( P= 0.001). AKI developed in 52% of the patients and was associated with a higher mortality (39.4%) as compared with those who did not have AKI (8.2%) ( P<0.001). The renal function outcome wascomparable between the two groups ( P= 0.37) (Table 1). On the other hand, we have observed a significant correlation between the blood glucose levels and the incidence of AKI ( P= 0.007) (Figure 1). In the multivariate logistic regression analysis, only previous diabetes mellitus and age higher than 60 years were risk factors for AKI. Independent risk factors for mortality were hypo- glycemia and APACHE III score >60." 2308 3248 W2005036511.pdf 16 27 separator 0.9958056 ¶ 3248 3250 W2005036511.pdf 16 28 title 0.9452882 Conclusions 3250 3262 W2005036511.pdf 16 29 text 0.9992666 "Intensive insulin therapy does not reduce the incidence of acute kidney injury evaluated through the RIFLE criteria when compared with a carbohydrate restrictive strategy." 3262 3438 W2005036511.pdf 16 30 separator 0.61856794 3438 3439 W2005036511.pdf 16 31 text 0.99492717 "¶ However, we have observed that an increase in the blood glucose levels beyond normal values is associated with an increase in the incidence of AKI. This, as well as the higher incidence of hypoglycemia, suggests that a carbohydrate restrictive strategy is safer than and as efficient as intensive insulin therapy in preventing AKI in critically ill patients." 3439 3809 W2005036511.pdf 16 32 separator 0.9961492 ¶ 3809 3811 W2005036511.pdf 16 33 title 0.56085366 References 3811 3822 W2005036511.pdf 16 34 separator 0.98620147 ¶ 3822 3824 W2005036511.pdf 16 35 bibliography 0.99445605 "1. Van den Berghe G, Wouters P, Weekers F, et al .: Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345:1359-1367. 2. Bellomo R, Ronco C, Kellum JA, et al.: Acute renal failure – defi- nition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Con- sensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2004, 8:R204-R212." 3824 4269 W2005036511.pdf 16 36 separator 0.9912423 ¶ 4269 4271 W2005036511.pdf 16 37 title 0.8694837 Pneumology 4271 4282 W2005036511.pdf 16 38 separator 0.8127904 ¶ 4282 4284 W2005036511.pdf 16 39 title 0.62928414 P38 4284 4288 W2005036511.pdf 16 40 separator 0.98423874 ¶ 4288 4290 W2005036511.pdf 16 41 title 0.4149991 "Experience in the intensive management of early postoperative lung transplantation patients of the Complexo" 4290 4400 W2005036511.pdf 16 42 bibliography 0.30369484 ¶ 4400 4402 W2005036511.pdf 16 43 title 0.36249703 Hospitalar Santa Casa Group of Porto Alegre, 4402 4447 W2005036511.pdf 16 44 paratext 0.26150903 Brazil 4447 4454 W2005036511.pdf 16 45 separator 0.94382286 ¶ 4454 4456 W2005036511.pdf 16 46 bibliography 0.9775236 "CDAO Costa, JJ Camargo, SM Schio, IA Melo, T Machuca, L Sanchez, SM Camargo, FA Perin, JC Felicetti, A Nogueira, V Lobato Complexo Hospitalar Santa Casa de Porto Alegre – RS, Brazil" 4456 4646 W2005036511.pdf 16 47 separator 0.5431432 ¶ 4646 4648 W2005036511.pdf 16 48 bibliography 0.8249478 Critical Care 2009, 13(Suppl 3): P38 (doi: 10.11 4648 4697 W2005036511.pdf 16 49 paratext 0.6448516 86/cc7840) 4697 4707 W2005036511.pdf 16 50 separator 0.99594927 ¶ 4707 4709 W2005036511.pdf 16 51 text 0.91234934 "Introduction After James Hardy’s pioneer initiative (1963) and the advance of lung preservation techniques, the progress of immuno- suppressive treatment with the discovery of cyclosporine and the" 4709 4910 W2005036511.pdf 16 52 bibliography 0.5564071 Available online http://ccforum.com/supplements/13/S3 4910 4963 W2005036511.pdf 16 53 separator 0.9906814 ¶ 4963 4965 W2005036511.pdf 16 54 caption 0.99006337 Figure 1 (abstract P37) 4965 4989 W2005036511.pdf 16 55 separator 0.742761 ¶ 4989 4991 W2005036511.pdf 16 56 caption 0.9870724 Acute kidney injury (AKI) according to glycemic levels. 4991 5047 W2005036511.pdf 16 57 separator 0.9522129 ¶ 5047 5049 W2005036511.pdf 16 58 table 0.9577626 "Table 1 (abstract P37) Results Group 1 Group 2 Renal outcome ( n= 118) ( n= 110) P value Unfavorable 17 20 Stable 64 76 0.27 Favorable 29 22" 5049 5203 W2005036511.pdf 16 0 paratext 0.9727974 | 3 4 8 W3016559957.pdf 2 1 separator 0.5726212 ¶ 8 10 W3016559957.pdf 2 2 title 0.94781655 DRETCHEN ET al. 10 26 W3016559957.pdf 2 3 separator 0.9939782 ¶ 26 28 W3016559957.pdf 2 4 text 0.9990644 "delivered 100 μL of epinephrine in a 200-μL capacity cannula (pi - pette tip) that was attached to a 100-μL calibrated pipette. No dead space was present in the cannula following dose delivery. The entire dose was delivered at a depth of three-quarters of an inch into the right nostril. For IM epinephrine administration, the autoinjector dosing procedure provided in the manufacturer's in - structions was utilized." 28 453 W3016559957.pdf 2 5 separator 0.99661535 ¶ 453 455 W3016559957.pdf 2 6 title 0.97929394 2.5 | Sample collection 455 479 W3016559957.pdf 2 7 separator 0.993618 ¶ 479 481 W3016559957.pdf 2 8 text 0.9988277 "Up to 2 mL of whole blood was collected (Vacuette® tube 4 mL K2EDTA [Greiner Bio-One]) via venous puncture from jugular or cephalic vein. Blood serum and plasma samples were separated from whole blood by centrifugation, kept on ice, and protected from light when possible during the collection, aliquoting, and transfer processes. The PK plasma samples were vortex-mixed for approxi - mately 1 minute, followed by centrifugation and aliquoting (typi - cally 3 × 100 μ L) into amber microcentrifuge tubes containing SMBS (5 μL). Following mixing, samples were transferred to the MRIGlobal Bioanalytical Group for analysis (one aliquot per PK sample)." 481 1144 W3016559957.pdf 2 9 separator 0.9971578 ¶ 1144 1146 W3016559957.pdf 2 10 title 0.9871212 2.6 | Bioanalysis of plasma samples 1146 1182 W3016559957.pdf 2 11 separator 0.99455094 ¶ 1182 1184 W3016559957.pdf 2 12 text 0.99644 "Plasma samples were analyzed for epinephrine concentrations using a calibrator range (lower limit of quantitation to upper limit of quantitation) of either 0.4 to 10 ng/mL or 1 to 32 ng/mL. Samples used for quality control (QC) were 0.4, 1, 3, and 5 ng/mL, and 1, 4, 12, and 24 ng/mL, respectively. Control plasma was heat treated (55°C for ~ 8 days) and stabilized with SMBS (~ 317 mg/mL) (plasma/SMBS = 98:2, volume/volume) before use. Calibrators, QCs, blanks, and incurred samples were prepared by solid-phase extraction using Biotage Evolute ® Express WCX (10 mg) 96-well plates (Uppsala, Sweden) and epinephrine-d6 as a true internal standard. The obtained extracts were analyzed by liquid chroma - tography tandem-mass spectrometry (LC-MS/MS) using a C18-PFP column. Analysis with LC-MS/MS was performed in positive electrospray ionization mode using multiple reaction monitoring ionization." 1184 2107 W3016559957.pdf 2 13 separator 0.9968221 ¶ 2107 2109 W3016559957.pdf 2 14 title 0.98682654 2.7 | Statistical analysis 2109 2137 W3016559957.pdf 2 15 separator 0.9964552 ¶ 2137 2139 W3016559957.pdf 2 16 text 0.99928004 "Epinephrine plasma concentrations were adjusted to account for the plasma epinephrine baseline concentration by subtracting the average concentration of three pre-dose samples (1, 12, and 60 min - utes prior to time 0) from the post-dose values for each dog. In ad - dition, epinephrine concentrations were considered as outliers and removed from analysis if they exceeded two times the standard de - viation from the mean of baseline-subtracted post-dose epinephrine plasma concentrations of each dog over the course of blood sam - pling (1 to 90 minutes post-dose)." 2139 2715 W3016559957.pdf 2 17 title 0.93494266 TABLE 1 PK parameters following IN or IM administration of epinephrine 2715 2785 W3016559957.pdf 2 18 separator 0.6486578 ¶ 2785 2787 W3016559957.pdf 2 19 table 0.9761916 "PK parametera IN epinephrine IM epinephrine 2 mg n = 63 mgn = 64 mgn = 65 mgn = 610 mgn = 620 mgn = 50.15 mgn = 60.3 mgn = 6 C max (ng/mL) 2.79 ± 0.96 2.37 ± 1.26 3.75 ± 1.71 3.43 ± 0.65 8.28 ± 1.97 23.28 ± 8.71 1.25 ± 0.19 2.81 ± 0.97 Tmax (minutes) 37.00 ± 15.48 20.17 ± 14.10 48.50 ± 13.15 41.67 ± 15.95 15.00 ± 3.42 15.20 ± 11.23 21.83 ± 8.74 31.67 ± 9.37 AUC0–90 (ng*minutes/ mL)95.59 ± 41.39 91.23 ± 41.35 192.49 ± 99.49 153.19 ± 20.13 207.56 ± 55.72 660.61 ± 323.75 58.93 ± 6.64 118.43 ± 19.40" 2787 3306 W3016559957.pdf 2 20 separator 0.95794165 ¶ 3306 3308 W3016559957.pdf 2 21 table 0.6374365 Ab 3308 3311 W3016559957.pdf 2 22 caption 0.6052005 breviations: AUC0–90, area under the plasma concentration-time curve from 0 to 90 3311 3392 W3016559957.pdf 2 23 table 0.4868924 minutes 3392 3400 W3016559957.pdf 2 24 caption 0.65317404 ; 3400 3401 W3016559957.pdf 2 25 table 0.49263382 Cmax 3401 3406 W3016559957.pdf 2 26 caption 0.5548199 , 3406 3408 W3016559957.pdf 2 27 table 0.49929604 maximum plasma 3408 3422 W3016559957.pdf 2 28 caption 0.4727858 3422 3423 W3016559957.pdf 2 29 table 0.5171554 concentration 3423 3436 W3016559957.pdf 2 30 caption 0.5439673 ; 3436 3437 W3016559957.pdf 2 31 table 0.6026332 IM 3437 3440 W3016559957.pdf 2 32 caption 0.502761 , 3440 3441 W3016559957.pdf 2 33 table 0.65482163 intramuscular 3441 3455 W3016559957.pdf 2 34 caption 0.48589736 ; 3455 3456 W3016559957.pdf 2 35 table 0.63203526 IN 3456 3459 W3016559957.pdf 2 36 caption 0.48966438 , 3459 3460 W3016559957.pdf 2 37 table 0.5851266 intranasal 3460 3471 W3016559957.pdf 2 38 caption 0.5866428 ; 3471 3472 W3016559957.pdf 2 39 table 0.48122102 PK 3472 3475 W3016559957.pdf 2 40 caption 0.61518335 , 3475 3476 W3016559957.pdf 2 41 table 0.4698617 pharmac 3476 3484 W3016559957.pdf 2 42 caption 0.6183958 "okinetic; Tmax, time to reach maximum plasma concentration." 3484 3546 W3016559957.pdf 2 43 separator 0.5121876 ¶ 3546 3548 W3016559957.pdf 2 44 caption 0.76100296 aResults are reported as mean ± standard error. 3548 3596 W3016559957.pdf 2 0 paratext 0.9865172 fnins-13-01251 November 26, 2019 Time: 18:19 # 3 0 48 W2991635263.pdf 2 1 separator 0.96553254 ¶ 48 50 W2991635263.pdf 2 2 title 0.9912629 Musaeus et al. Microstates in Down Syndrome and Alzheimer’s Disease 50 118 W2991635263.pdf 2 3 separator 0.95740795 ¶ 118 120 W2991635263.pdf 2 4 text 0.998294 "system. For impedance, the aim was to reach below 10 kOhm for all electrodes during the recordings. However, we do not have any records of the impedance before or after the recording." 120 308 W2991635263.pdf 2 5 separator 0.9948168 ¶ 308 310 W2991635263.pdf 2 6 title 0.98511326 "Preprocessing of Electroencephalography" 310 352 W2991635263.pdf 2 7 separator 0.99147046 ¶ 352 354 W2991635263.pdf 2 8 text 0.99969405 "Results from analysis of spectral power have been presented elsewhere (Salem et al., 2015; Musaeus et al., 2019b). All preprocessing was performed in MATLAB (Mathworks, v2016a) using the EEGLAB toolbox (Delorme and Makeig, 2004). The electrodes were computationally located on the scalp using the DIPFIT toolbox (Oostenveld et al., 2011) with the standard 10– 20 cap model. The excessive channels were removed, and the data was bandpass filtered from 1 to 70 Hz, and bandstop filtered from 45 to 55 Hz using the pop_firws function in MATLAB, with a filter order of 2. Afterward, the data were then re- referenced to a common average montage. Then segments of both eyes open and closed were selected. Next, the data was divided into 1-s epochs and the EEGs were visually inspected and epochs with excessive artifacts were removed. If there was less than three channels with excessive artifacts, they were then interpolated using spherical interpolation otherwise the segments were rejected. Afterward, independent component analysis was performed with the extended infomax algorithm (Lee et al., 1999), and components containing eye blinks or eye movement were removed. Lastly, the EEGs were visually inspected and epochs with artifacts were removed. The person performing the preprocessing was blinded to whether the participants were DS or DS-AD." 354 1742 W2991635263.pdf 2 9 separator 0.95822144 ¶ 1742 1744 W2991635263.pdf 2 10 text 0.9996707 "After the preprocessing, only subjects with at least 30 1-s epochs were used for further analysis. Furthermore, all epochs were selected within the first 30 s after the participants closed their eyes to avoid any effects from drowsiness or sleep. In the eyes closed condition, EEGs from 16 DS-AD, and 12 DS were included. We did not look at the eyes open segments due to the varying activities and focus for the participant when they had their eyes open." 1744 2211 W2991635263.pdf 2 11 separator 0.99668676 ¶ 2211 2213 W2991635263.pdf 2 12 title 0.991267 Microstate Analysis 2213 2233 W2991635263.pdf 2 13 separator 0.99541485 ¶ 2233 2235 W2991635263.pdf 2 14 text 0.9996075 "The microstates analysis was performed using the Microstate EEGlab Toolbox (Poulsen et al., 2018). Before the microstate analysis, we first band-pass filtered the data between 2 and 20 Hz with the same settings as mentioned above. Afterward, we concatenated the epochs for each subject, i.e., ending up having one continuous EEG file instead of 1-s epochs. To assure thequality of the individual microstate maps, we first extracted the global field power (GFP) peaks for each participant with the following settings: minimum peak distance of 10 ms, the number of GFP peaks was set at the maximum for the shortest EEG file, and GFP peaks that exceeded two times the standard deviation of the GFP of all maps were excluded. For segmentation, we used the Topographic Atomize and Agglomerate Hierarchical Clustering (TAAHC) algorithm. Afterward, each map was visually inspected and subsequently removed from the analysis if they did not resemble the four maps previous reported in the literature (Michel and Koenig, 2018). Here, we excluded EEGs from two persons with DS, and one person with DS-AD." 2235 3356 W2991635263.pdf 2 15 separator 0.9217987 ¶ 3356 3358 W2991635263.pdf 2 16 text 0.99933195 "In the final analysis, we concatenated the GFP peaks from all subjects (n DS= 10, n DS" 3358 3446 W2991635263.pdf 2 0 paratext 0.9026344 1 0 1 W4362536676.pdf 0 1 separator 0.9848746 ¶ ¶ 2 9 W4362536676.pdf 0 2 title 0.9249622 Supplemental Table S1 . IC50s ( nM) for inhibition of enzyme activity for PARP family members 9 103 W4362536676.pdf 0 3 separator 0.9691499 ¶ 105 107 W4362536676.pdf 0 4 table 0.9933091 "Veliparib Olaparib Talazoparib Rucaparib A-934935 PARP1 1.05 +0.4 0.47 +0.04 0.50 +0.03 0.38 +0.01 0.77 +0.03 PARP2 0.42 +0.09 0.27 +0.01 0.26 +0.04 0.26 +0.01 0.31 +0.02 PARP3 98.3 +10.0 15.9 +2.96 23.4 +3.41 19.2 +4.73 109 +16.2 TNKS1 7,573 +2,011 1,447 +72.3 17.7 +2.1 296 +5.0 121 +16.3 TNKS2 1,927 +696 579 +53.6 5.13 +1.1 66.7 +41.2 21.1 +9.7 PARP6 > 10 ,000 1,137 +545 530 +179 > 10 ,000 > 10 ,000 PARP7 > 10 ,000 1,522 +1,099 > 10 ,000 > 10 ,000 > 10 ,000 PARP8 > 10 ,000 1,319 +622 254 +129 > 10 ,000 3,213 +1,350 PARP10 > 10 ,000 589 +269 9,293 +1,852 446 +89.8 2,410 +272 PARP11 No Inhibition 79% @ 10 μM 596 +100 1,200 +173 No Inhibition PARP12 > 10 ,000 3,577 +790 > 10 ,000 6,240 +1,629 6,680 +1,205 PARP15 > 10 ,000 5,483 +588 > 10 ,000 > 10 ,000 > 10 ,000" 108 1372 W4362536676.pdf 0 5 separator 0.99226797 ¶ 1374 1376 W4362536676.pdf 0 0 paratext 0.988702 Materials 2017 ,10, 1401 3 of 9 0 31 W2774662964.pdf 2 1 separator 0.9944312 ¶ 31 33 W2774662964.pdf 2 2 text 0.90238523 Dowling et al. reported 0and a to be 0.883 and 2 33 83 W2774662964.pdf 2 3 paratext 0.8652324 10 83 87 W2774662964.pdf 2 0 bibliography 0.99803656 "24. 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JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2016;44:D110 –5." 477 702 W2800572547.pdf 7 9 separator 0.96152866 ¶ 702 704 W2800572547.pdf 7 10 bibliography 0.9980848 "29. Ghittoni R, Accardi R, Chiocca S, Tommasino M. Role of human papillomaviruses in carcinogenesis. Ecancermedicalscience. 2015;9:526." 704 842 W2800572547.pdf 7 11 separator 0.9587631 ¶ 842 844 W2800572547.pdf 7 12 bibliography 0.9980285 "30. Chen Z, Jing Y, Wen Q, Ding X, Wang T, Mu X, et al. E6 and E7 gene polymorphisms in human papillomavirus Types-58 and 33 identified in Southwest China. PLoS One. 2017;12:e0171140." 844 1032 W2800572547.pdf 7 13 separator 0.9640813 ¶ 1032 1034 W2800572547.pdf 7 14 bibliography 0.99790937 "31. Liu JH, Lu ZT, Wang GL, Zhou WQ, Liu C, Yang LX, et al. Variations of human papillomavirus type 58 E6, E7, L1 genes and long control region in strains from women with cervical lesions in Liaoning province, China. Infect Genet Evol. 2012;12:1466 –72." 1034 1294 W2800572547.pdf 7 15 separator 0.9741421 ¶ 1294 1296 W2800572547.pdf 7 16 bibliography 0.99800414 "32. Chan PK, Lam CW, Cheung TH, Li WW, Lo KW, Chan MY, et al. Association of human papillomavirus type 58 variant with the risk of cervical cancer. J Natl Cancer Inst. 2002;94:1249 –53." 1296 1486 W2800572547.pdf 7 17 separator 0.9626695 ¶ 1486 1488 W2800572547.pdf 7 18 bibliography 0.99801344 "33. Ding T, Wang X, Ye F, Cheng X, Ma D, Lu W, et al. Distribution of human papillomavirus 58 and 52 E6/E7 variants in cervical neoplasia in Chinese women. Gynecol Oncol. 2010;119:436 –43." 1488 1681 W2800572547.pdf 7 19 separator 0.9676652 ¶ 1681 1683 W2800572547.pdf 7 20 bibliography 0.9979713 "34. Murakami M, Gurski KJ, Marincola FM, Ackland J, Steller MA. Induction of specific CD8+ T-lymphocyte responses using a human papillomavirus-16 E6/E7 fusion protein and autologous dendritic cells. Cancer Res. 1999;59:1184 –7." 1683 1915 W2800572547.pdf 7 21 separator 0.97041214 ¶ 1915 1917 W2800572547.pdf 7 22 bibliography 0.9978547 "35. Yang A, Jeang J, Cheng K, Cheng T, Yang B, Wu TC. Current state in the development of candidate therapeutic HPV vaccines. Expert Rev Vaccines. 2016;15:989 –1007." 1917 2087 W2800572547.pdf 7 23 separator 0.9716418 ¶ 2087 2089 W2800572547.pdf 7 24 bibliography 0.99806577 "36. Cornet I, Gheit T, Franceschi S, Vignat J, Burk RD, Sylla BS, et al. Human papillomavirus type 16 genetic variants: phylogeny and classification based on E6 and LCR. J Virol. 2012;86:6855 –61." 2089 2290 W2800572547.pdf 7 25 separator 0.9657154 ¶ 2290 2292 W2800572547.pdf 7 26 bibliography 0.99791163 "37. Miettinen M, McCue PA, Sarlomo-Rikala M, Biernat W, Czapiewski P, Kopczynski J, et al. Sox10 –a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015;39:826 –35." 2292 2579 W2800572547.pdf 7 27 separator 0.9733943 ¶ 2579 2581 W2800572547.pdf 7 28 bibliography 0.99776083 "38. Tong X, Li L, Li X, Heng L, Zhong L, Su X, et al. SOX10, a novel HMG-box- containing tumor suppressor, inhibits growth and metastasis of digestive cancers by suppressing the Wnt/ β-catenin pathway. Oncotarget. 2014;5: 10571 –83." 2581 2820 W2800572547.pdf 7 29 separator 0.97877294 ¶ 2820 2822 W2800572547.pdf 7 30 bibliography 0.99590325 "39. Zhong WD, Qin GQ, Dai QS, Han ZD, Chen SM, Ling XH, et al. SOXs in human prostate cancer: implication as progression and prognosis factors. BMC Cancer. 2012;12:248.Xiet al. Virology Journal (2018) 15:76" 2822 3034 W2800572547.pdf 7 31 paratext 0.9549433 Page 8 of 8 3034 3046 W2800572547.pdf 7 0 paratext 0.9101713 Original Paper 0 14 W4210556692.pdf 0 1 separator 0.6644157 ¶ 14 16 W4210556692.pdf 0 2 title 0.9855199 Effect of Serial Anthropometr ic Measurements and Motiv ational 16 80 W4210556692.pdf 0 3 separator 0.6632744 ¶ 80 82 W4210556692.pdf 0 4 title 0.92776257 "Text Messages on Weight Reduction Among Workers:Pilot Randomiz ed Controlled Trial" 82 167 W4210556692.pdf 0 5 separator 0.9711623 ¶ 167 169 W4210556692.pdf 0 6 contact 0.92366016 "Renee Chan1, MBBS; Matthe w Nguyen1, MBBS; Rachel Smith1, MBBS; Sarah Spencer1, MBBS; Sabrina Winona Pit1,2, PhD, MSc, Dip (OHS)" 169 300 W4210556692.pdf 0 7 separator 0.9220767 ¶ 300 302 W4210556692.pdf 0 8 contact 0.98312026 "1School Of Medicine, University Centre for Rural Health, Western Sydne y University , Lismore, Australia 2Rural Clinical School, University of Sydne y, Lismore, Australia Corr esponding Author: Sabrina Winona Pit, PhD, MSc, Dip (OHS) School Of Medicine University Centre for Rural Health Western Sydne y University 62 Uralba Street Lismore, 2480 Australia Phone: 61 266207570 Email: sabrina.pit@sydne y.edu.au" 302 734 W4210556692.pdf 0 9 separator 0.99432325 ¶ 734 736 W4210556692.pdf 0 10 title 0.9821089 Abstr act 736 746 W4210556692.pdf 0 11 separator 0.99242204 ¶ 746 748 W4210556692.pdf 0 12 text 0.9995352 "Backgr ound: Obesity is an endemic problem with signif icant health and financial consequences. Text messaging has been shown to be a simple and effective method of facilitating weight reduction. In addition, waist-to-hip ratio (WHR) has emer ged as a signif icant anthropometric measure. However, few studies have examined the effect of serial anthropometric self-measurement combined with text messaging." 748 1161 W4210556692.pdf 0 13 separator 0.82483387 ¶ 1161 1163 W4210556692.pdf 0 14 text 0.9990372 "Objecti ve: The primary aim of this study was to assess whether an 8-week program, consisting of weekly serial self-measurements of waist and hip circumference, combined with motivational text messages, could reduce WHR among Australian workers." 1163 1411 W4210556692.pdf 0 15 separator 0.9059466 ¶ 1411 1413 W4210556692.pdf 0 16 text 0.9987775 "Methods: This was a community-based, participant-blinded, staggered-entry , parallel group study . Adult workers with access to mobile phones were eligible and recruited through an open access Web-based survey. Participants were randomly allocated to recei ve interv ention or control messages for 8 weeks. Outcome data were self-assessed through a Web-based survey." 1413 1784 W4210556692.pdf 0 17 separator 0.9064307 ¶ 1784 1786 W4210556692.pdf 0 18 text 0.9991489 Results: A total of 60 participants were randomized with 30 participants each allocated to a control and an interv ention group. 1786 1915 W4210556692.pdf 0 19 separator 0.74479127 ¶ 1915 1917 W4210556692.pdf 0 20 text 0.99917954 "There was no signif icant change in WHR (P=.43), and all secondary outcome measures did not differ between the interv ention group and the control group at the end of the 8-week interv ention. Both groups, however, showed a signif icant decrease in burnout over time (mean [SE]: pre 4.80 [0.39] vs post 3.36 [0.46]; P=.004). The interv ention uptak e followed a downw ard trend. Peak participant replies to weekly self-measurements were recei ved in week 3 (14/23, 61%) and the least in week 8 (8/23, 35%). No harm was found to result from this study ." 1917 2478 W4210556692.pdf 0 21 separator 0.91668177 ¶ 2478 2480 W4210556692.pdf 0 22 text 0.9988113 "Conclusions: This study is an innovative pilot trial using text messaging and serial anthropometric measurements in weight management. No change was detected in WHRs in Australian workers over 8 weeks; therefore, it could not be concluded whether the interv ention affected the primary outcome. However, these results should be interpreted in the conte xt of limited sample size and decreasing interv ention uptak e over the course of the study . This pilot trial is useful for informing and contrib uting to the design of future studies and the growing body of literature on serial self-measurements combined with text messaging." 2480 3119 W4210556692.pdf 0 23 separator 0.95745355 ¶ 3119 3121 W4210556692.pdf 0 24 paratext 0.38733038 Trial Registration: Australian New Zealand Clinical Trials Registry ACTRN12616001496404; 3121 3210 W4210556692.pdf 0 25 bibliography 0.41250464 3210 3211 W4210556692.pdf 0 26 paratext 0.40170988 ¶ 3211 3212 W4210556692.pdf 0 27 bibliography 0.51739347 https://www . 3212 3226 W4210556692.pdf 0 28 paratext 0.4814342 anzctr 3226 3232 W4210556692.pdf 0 29 bibliography 0.5233842 .org. 3232 3238 W4210556692.pdf 0 30 paratext 0.43379375 au 3238 3240 W4210556692.pdf 0 31 bibliography 0.4711953 / 3240 3241 W4210556692.pdf 0 32 paratext 0.4308343 T 3241 3242 W4210556692.pdf 0 33 bibliography 0.48846155 rial/Re 3242 3251 W4210556692.pdf 0 34 paratext 0.4372241 gistration 3251 3261 W4210556692.pdf 0 35 bibliography 0.45319745 / 3261 3262 W4210556692.pdf 0 36 paratext 0.45940357 T 3262 3263 W4210556692.pdf 0 37 bibliography 0.49027884 "rialRe view.aspx?id=371696&isRe view=true (Archi ved by WebCite at http://www .web" 3263 3348 W4210556692.pdf 0 38 paratext 0.44335312 citation 3348 3356 W4210556692.pdf 0 39 bibliography 0.46528798 . 3356 3357 W4210556692.pdf 0 40 paratext 0.43457136 or 3357 3359 W4210556692.pdf 0 41 bibliography 0.50657094 3359 3360 W4210556692.pdf 0 42 paratext 0.8429483 "g/73UkKFjSw) (JMIR Mhealth Uhealth 2019;7(4):e11832) doi: 10.2196/11832" 3360 3433 W4210556692.pdf 0 43 separator 0.86565983 ¶ 3433 3435 W4210556692.pdf 0 44 paratext 0.5192755 3435 3436 W4210556692.pdf 0 45 title 0.6062494 KEYW ORDS 3436 3445 W4210556692.pdf 0 46 separator 0.81919634 ¶ 3445 3447 W4210556692.pdf 0 47 paratext 0.61618185 text messages; obesity; waist-hip ratio; weight reduction programs; mHealth 3447 3523 W4210556692.pdf 0 48 separator 0.9565706 ¶ 3523 3525 W4210556692.pdf 0 49 paratext 0.9078319 "JMIR Mhealth Uhealth 2019 | vol. 7 | iss. 4 | e11832 | p. 1 https://mhealth.jmir .org/2019/4/e11832/ (page number not for citation purposes)Chan et al JMIR MHEAL TH AND UHEAL TH XSL•FO RenderX" 3525 3724 W4210556692.pdf 0 0 separator 0.62585163 "¶ ¶ ¶" 1 18 W4225876167.pdf 4 1 paratext 0.81863064 "Publisher: Jurusan Kebidanan P oltekkes K emenkes Malang Website: www. http://ojs. poltekkes -malang.ac.id/index.php/MAJORY" 19 150 W4225876167.pdf 4 2 separator 0.959911 ¶ 152 154 W4225876167.pdf 4 3 title 0.9583836 39 DISKUSI 154 165 W4225876167.pdf 4 4 separator 0.99521625 ¶ 167 169 W4225876167.pdf 4 5 text 0.9984557 "Menurut WHO (2013) , kepatuhan merupakan fenomena multidimens i yang ditent ukan oleh beb erapa faktor selain dari pasien itu sendiri, juga ada faktor lima dimensi yang saling terkait, yaitu faktor terapi, faktor sistem kesehatan, faktor lingkungan, faktor sosial ekonomi dan faktor dukungan keluarga, selain itu menurut Menurut Mori sky (2009)" 169 539 W4225876167.pdf 4 6 separator 0.688065 541 542 W4225876167.pdf 4 7 text 0.9961285 "¶ beberapa alasan ketidakpatuhan minum obat sebagai berikut : lupa, sengaja tidak minum obat, merasa kondisi memburuk, lupa membawa ketika bepergian, merasa kondisi membaik, menganggu keharusan minum obat. Hasil penelitian menunjukkan kepatuhan mengkonsumsi ta blet tambah darah sebelum menggunakan aplikasi reminder berbasis android dalam kategori rendah (100%. ) Hal ini dikarenakan tidak ada yang mengingatkan saat minum tablet tambah darah (100%) , tidak nyaman dalam mematuhi rencana p engobatan (93%) , dan kesulita n dalam mengingat penggunaan obat (56%)." 542 1151 W4225876167.pdf 4 8 separator 0.9723694 ¶ 1154 1156 W4225876167.pdf 4 9 text 0.99944365 "Hasil penelitian ini sejalan dengan penelitian yang dilakukan Riza (2015:15 - 23) menunjukkan bahwa pasien dengan tingka t kepatuhan tinggi 20 pasien (18,2%), tingkat kepatuhan sedang 43 pasien (39,1%), dan tingkat k epatuhan rendah 47 pasien (42,7%) saat sebelum diberikan intervensi. Kebanyakan pasien mengabaikan akan pentingnya pengobatan disebabkan oleh ketidaksengajaan (contohnya kelalaian atau terlupa minum obat), sengaja (tidak minum obat saat merasa penyakitnya bertambah p arah atau mem baik), dan kurangnya pengetahuan tentang penyakit dan tujuan pengobatannya. Hasil penelitian ini juga sejalan dengan penelitian Alfian (2015:129 -138) bahwa alasan ketidakpatuhan pasien yang diketahui dengan alas an lupa memin um obat sebesar 54,76 %, sengaja tidak minum obat sebesar 33,33 %, merasa kondisi lebih baik sebesar 33,33 %. Lupa, sengaja tidak minum , persepsi bahwa kondisinya membaik , dan tidak ada yang mengingatkan waktu konsumsi o bat merupakan alasan rendahnya kepatuhan konsum si ob at." 1156 2239 W4225876167.pdf 4 10 separator 0.990556 ¶ 2240 2242 W4225876167.pdf 4 11 text 0.9983503 "Hasil penelitian menunjukkan kepatuhan minum tablet tambah darah setelah menggunakan aplikasi reminder berbasis android ini responden yang masuk dalam kategori kepatuhan tinggi (53,3%), sedang (6,7%), dan r endah (40%)." 2242 2481 W4225876167.pdf 4 12 separator 0.959087 ¶ 2482 2484 W4225876167.pdf 4 13 text 0.9986346 "Kepatuhan minum tablet tamba h darah pada remaja putri anemia mengalami peningkatan dikarenakan remaja putri sudah memiliki persepsi dan daya ingat yang lebih baik mengenai cara mengkonsumsi tablet tambah darah yang benar dibuktikan dengan adanya peningkatan skor setelah diberikan apl ikasi reminder ." 2484 2814 W4225876167.pdf 4 14 separator 0.9740443 ¶ 2815 2817 W4225876167.pdf 4 15 text 0.999515 "Hasil penelitian ini sejalan dengan penelitian yang dilakukan oleh Alfian (2015:129 -138) menunjukkan tingkat kepatuhan minum obat pasien diabetes pada kelompok intervensi setelah dipasangkan aplikasi digital pengingat minum obat lebih besar (60,0%) dibanding kelompok kontrol (8,0%) peningkatan kepatuhan. Berdasarkan hasil penelitian ini dan penelitian terdahulu, membuktikan bahwa aplikasi reminder memiliki pengar uh terhadap kepatuhan seseorang, dikarenakan adanya stimulus untuk mengingat wak tu minum obat sesuai yang dianjurkan." 2817 3402 W4225876167.pdf 4 16 separator 0.77013147 ¶ 3404 3406 W4225876167.pdf 4 17 text 0.994917 "Penggunaan aplikasi reminder berbasis android dalam penelitian ini memberikan pengingat yang tepat pada responden untuk mengkonsumsi tab let" 3406 3557 W4225876167.pdf 4 18 paratext 0.8252001 Silvi Maya Asrina | 3557 3578 W4225876167.pdf 4 19 title 0.8158917 Kepatuhan Remaja Minum Tablet Tambah Darah Sebelum dan Setelah Menggunakan Aplikasi Reminder (Pengingat) 3578 3684 W4225876167.pdf 4 20 separator 0.997077 ¶ 3686 3688 W4225876167.pdf 4 0 text 0.6972902 vltrt[avibtgrh5vlravthEvltAaokae2lrumovaevs5trtmtasort2. ae2chvlslh5t2s[h5tr 0 76 W2536588821.pdf 11 1 separator 0.7200704 ¶ 76 78 W2536588821.pdf 11 2 text 0.829974 grh5vlieTFmt2iomuhmRart2 5ivlvlt5i[2-v1Rt svraie3 78 128 W2536588821.pdf 11 3 separator 0.977049 ¶ 128 130 W2536588821.pdf 11 4 title 0.9470788 Discussion 130 141 W2536588821.pdf 11 5 separator 0.98564386 ¶ 141 143 W2536588821.pdf 11 6 text 0.98172134 ")evlissvo21.5tEhoe2vlavvltT)AsEhrvigtu1u[iet ieurtast2 ieasvtR-5ist maeetr5ivlvlt Rrtsteut hEmovavihes ievltAaokhRtrheae2vltlruae2Ansggtets3:orvraesuriRvihea[ aea[- " 143 311 W2536588821.pdf 11 7 separator 0.5319962 ¶ 311 312 W2536588821.pdf 11 8 text 0.93997276 1sisrtso[vsslh5t2vlavvltAaokhRtrheisligl[1t0Rrtsst2 iea[[stbtevigtu1u[iet-rtsisvaev 312 397 W2536588821.pdf 11 9 separator 0.58497894 ¶ 397 398 W2536588821.pdf 11 10 text 0.9815982 "K3nuemoruiae svraies.ie2iuavieg vlavvltAaokhRtrheR[a1saeimRhrvaev rh[tievigtu1u[iet rtsisvaeut ieK3nuemoruiae3 SltAaokgtet.[huavt2oRsvrtam hEAaoR.teuh2tsavraesuriR- vihea[rtRrtsshr ct[hegieg vhvltStvMEami[1.ae2amovavihe ieAaok[ta2svhvlthbtrt0Rrts- sihehEAaoR]w6.wNp3Slisrtgo[avihe isaulitbt2 biavltcie2ieghEMamMvhvltRrhmhvtr hE AaoR]–kp3Ihes1ehe1mhos movavihes ieAaokartrtRhrvt2 5ivlliglErtjoteu1 ievigtu1- u[iet-ehe-sosutRvic[t K3nuemoruiae u[ieiua[ish[avts]Hp3+ta[shi2teviEit2 castsocsvivovihes." 398 906 W2536588821.pdf 11 11 separator 0.78235614 ¶ 906 908 W2536588821.pdf 11 12 text 0.97041416 iestrvihes ae22t[tvihes ievltAaokgtetLHμHUieK3nuemoruiae. uheEirmieg vltstRrtbihos 908 991 W2536588821.pdf 11 13 separator 0.65879476 ¶ 991 993 W2536588821.pdf 11 14 text 0.9737549 "Eie2iegs3 Sltstrtso[vsie2iuavtvlavAaokmovavihe isauhmmhe mtulaeism iebh[bt2 ievigt- u1u[ietrtsisvaeut3 SltWheRrhvtastisiebh[bt2 ievlt2tgra2avihe hETarqieEsfteAiftia frli]–,p3q[hss-hE- Eoeuvihemovavihe ielru5ho[2[ta2vhligltruheutevravihes hETarq.5liul5ho[2ieurtast t0Rrtssihe hEvltqurqXtEE[o0RomR3+t2tvtuvt2vlrtt2iEEtrtev v1RtshERhievmovavihes ie vltlrugtet.ae2uhmR[tmtevavihe ae2gtetéehuéhov t0Rtrimtevs 2tmhesvravt2 vlavlru movaevst0licivt2 ligltrrtsisvaeut vhvigtu1u[iet vlae5i[2-v1Rt K3nuemoruiae3 )eauvibavihe hElruisiebh[bt2 ievltmtulaeism hEvigtu1u[iet rtsisvaeut ieE3frliae2y3dvntiomAimo ]–w. " 993 1608 W2536588821.pdf 11 15 separator 0.58177453 ¶ 1608 1609 W2536588821.pdf 11 16 text 0.93430424 ––p3ShvltctsvhEhoréeh5[t2gt. vlissvo21ieu[o2tsvltEirsvuhesvrouvihe hEalrumovaevie 1609 1692 W2536588821.pdf 11 17 separator 0.49527058 ¶ 1692 1693 W2536588821.pdf 11 18 text 0.93196946 "K3nuemoruiae. 5liula[[h5t2uheEirmavihe hEvltasshuiavihe hEmovavihes ievlisgtet5ivl vigtu1u[iet rtsisvaeut3 qvraesuriRv aea[1sisslh5t2vlav'Fw,,.'Fw,w.'Fw,9ae2'Fw,B " 1693 1859 W2536588821.pdf 11 19 separator 0.52878803 ¶ 1859 1860 W2536588821.pdf 11 20 text 0.7946079 Rrtstevt2 ligltrt0Rrtssihe [tbt[shErqxRSuhmRart2 5ivlvlt5i[2-v1Rt svraie3Sltstrtso[vs 1860 1947 W2536588821.pdf 11 21 separator 0.64256334 ¶ 1947 1948 W2536588821.pdf 11 22 text 0.85438114 "soggtsvvlavMarqae2:j0qXR[a1aeimRhrvaev rh[tie[achravhr1-tbh[bt2 vigtu1u[iet-rtsis- vaevsvraies]–8p.5ltrtasvltt0Rrtssihe hErqxRSmiglvctrtgo[avt2 c1lruiea[[Ehorsvraies vlavlarchrlrumovavihes3 MRsJisvlhoglvvhauvasagtetra[vargtvhEvigtu1u[iet a2aRvihe ae2amarétrEhra[vtravihes ieaevicihviu rtsisvaeut iecauvtria]–9p3SltRrhvtieteuh2t2c1vltAnsggtetisauhmRhetev hE vlt–k7richshma[ socoeivae2RarviuiRavts ievltEhrmavihe hEaXh0q-cie2ieg mh2o[t]–Bp3 Vi[[aeEal3rtRhrvt2 aeamiehaui2socsvivovihe hEV9HWieK3nuemoruiae Ansg]6p.ae2hor rtso[vsuheEirmt2 vltRrtsteut hEvlisamiehaui2socsvivovihe ievlisgtet3SltV9HWmovavihe " 1948 2565 W2536588821.pdf 11 23 separator 0.4415813 ¶ 2565 2566 W2536588821.pdf 11 24 text 0.6809101 miglvuaost5taétrcie2ieghEvigtu1u[iet vh,B7rMIq.[ta2iegvhvigtu1u[iet rtsisvaeut ]6p3 2566 2650 W2536588821.pdf 11 25 separator 0.7237342 ¶ 2650 2652 W2536588821.pdf 11 26 text 0.921983 Slt7,kmovavihe lasa[shcttertRhrvt2 ieEuEeArfrffms faefimo. E3frli.yEantvlrfrffms 2652 2733 W2536588821.pdf 11 27 separator 0.47609958 2733 2734 W2536588821.pdf 11 28 text 0.84827477 "¶ amAems.yEAenErfrffms nuemoruiae ae2RfiueErbafEeA bamoauuii ]–9.–H.–6p3Fh5tbtr. 5t2i2 ehvaulitbtAnsgéehuéhov ieK3nuemoruiae3 )ea22ivihe. a[[avvtmRvs vhaulitbta[[t[iurtR[aut- mtevavvlis[huosieE3frli.R3bamoauuii ae2E3faefimolabtEai[t2]–9.–Np3SlisEai[ort uho[2ct2otvhvlttsstevia[rh[thE7,kievraes[avihe ae2vraesuriRvihe3" 2734 3057 W2536588821.pdf 11 29 title 0.9804406 Table 5.Tigecycli neMICs and relative growt hrates ofK.pneumoni aeXH209 and itsisogenic mutants . 3057 3154 W2536588821.pdf 11 30 separator 0.99101543 ¶ 3154 3156 W2536588821.pdf 11 31 table 0.9875907 "Strain Genotyp e TGC MIC (mg/L) Relative growt hrate Broth E-test XH209 wt 2 1 100.0 XH872 ΔramR::ap r 16 12 93.6 XH889 Δlon::apr 8 3 96.3" 3156 3303 W2536588821.pdf 11 32 separator 0.63551724 ¶ 3303 3305 W2536588821.pdf 11 33 paratext 0.8437271 doi:10.13 71/journal.pone .0165019.t005 3305 3345 W2536588821.pdf 11 34 separator 0.9906028 ¶ 3345 3347 W2536588821.pdf 11 35 title 0.97821134 The Role oframR, lonandrpsJ inTigecycline Resistanc e 3347 3401 W2536588821.pdf 11 36 separator 0.8925086 ¶ 3401 3403 W2536588821.pdf 11 37 paratext 0.98614657 PLOS ONE |DOI:10.1 371/journ al.pone.0165 019 October 20,2016 12/16 3403 3471 W2536588821.pdf 11 0 paratext 0.98984534 Toxics 2023 ,11, 765 7 of 18 0 28 W4386601127.pdf 6 1 separator 0.67584527 28 29 W4386601127.pdf 6 2 paratext 0.95829654 ¶ Toxics 2023 , 11 , x 7 of 19 29 60 W4386601127.pdf 6 3 separator 0.97934884 ¶ 62 64 W4386601127.pdf 6 4 text 0.99737936 "intervention group mice was relatively mild on days 7 and 42. The same outcomes were observed using the Szapiel inflammatory score (Figur e 3B, C)." 65 215 W4386601127.pdf 6 5 separator 0.99579644 ¶ 216 218 W4386601127.pdf 6 6 title 0.992624 3.2.2. Masson Staining 218 241 W4386601127.pdf 6 7 separator 0.9949622 ¶ 242 244 W4386601127.pdf 6 8 text 0.9996598 "Masson staining results (Figure 3D) showed that on day 7, the alveolar structure of the lung tissue in the control group mice was intac t, and no obvious collagen fiber depo- sition was found, with only a small amount of strom al collagen fibers (blue stained area) present around the walls of the large airways and b lood vessels. The Masson staining re- sults of lung tissues in the SiO 2 group and Tet intervention group mice were similar to those in the control group, which may be related to the fact that inflammation is mainly present in the early stage of silica dust exposure, while tissue fibrosis repair mainly occurs in the mid to late stage. The quantitative analysis of collagen fibers stained by Masson showed that there was no significant difference in co llagen fiber area between the SiO 2 group and the Tet intervention group in the lung ti ssues of mice compared to the control group (Figure 3E)." 244 1187 W4386601127.pdf 6 9 separator 0.9816128 ¶ 1188 1190 W4386601127.pdf 6 10 text 0.9995895 "On day 42, blue-stained collagen fiber deposition co uld be observed in the alveolar septa and bronchial walls of SiO 2 group mice, and the degree of collagen deposition in the Tet intervention group was lower than that in the S iO 2 group. Similarly, quantitative anal- ysis results indicate that the area of collagen fibe rs in the lung tissues of SiO 2 group mice was significantly increased compared to the control group ( p < 0.05). Compared with the SiO 2 group, the area of collagen fibers in the Tet inter vention group decreased significantly (p < 0.05) (Figure 3F)." 1190 1779 W4386601127.pdf 6 11 separator 0.9878822 ¶ ¶ 1780 1786 W4386601127.pdf 6 12 caption 0.9493995 "Figure 3. Histopathological changes in mouse lungs. ( A) Representative HE staining images of lung sections (200×) from each group of mice on days 7 a nd 42 of SiO 2 exposure ( n = 3). (B) Szapiel scores for HE staining after the 7-day experiment were sta tistically analyzed. ( C) The statistical evaluation of the Szapiel scores for the 42-day experiment’s H E staining. ( D) The representative images of Figure 3. Histopathological changes in mouse lungs. ( A) Representative HE staining images of lung sections (200 ) from each group of mice on days 7 and 42 of SiO 2exposure ( n =3). (B) Szapiel scores for HE staining after the 7-day experiment were statistically analyzed. ( C) The statistical evaluation of the Szapiel scores for the 42-day experiment’s HE staining. ( D) The representative images of Masson staining of lung tissue sections from each group of mice (200 ) (n =3). (E) The results of the quantitative Masson staining analysis after the 7-day trial. ( F) The outcomes of the quantitative Masson staining analysis after the 42-day experiment. Results are expressed as mean SD, compared with the control group, *** p< 0.001, ** p< 0.01; Compared with SiO 2group,#p< 0.05,###p< 0.001." 1786 3019 W4386601127.pdf 6 13 separator 0.9960642 ¶ 3019 3021 W4386601127.pdf 6 14 title 0.99200743 "3.3. Tet Could Relieve SiO 2-Induced Inflammation by Inhibiting Inflammatory Cytokines TNF- a, IL-1b, MCP-1, and TGF- b1 mRNA in the Lung Tissues of Mice" 3021 3175 W4386601127.pdf 6 15 separator 0.9941181 ¶ 3175 3177 W4386601127.pdf 6 16 text 0.99950236 "According to the results of RT-qPCR, on day 7, SiO 2exposure increased the levels of TNF- a,IL-1b,MCP-1 , and TGF- b1mRNA expression in the lung tissue of mice by 4.88, 6.97, 4.12, and 0.45 times, respectively, in comparison to the control group (all p< 0.05). In addition, compared with the SiO 2group, the expression levels of TNF- a,IL-1b,MCP-1 , and TGF- b1mRNA in the Tet intervention group decreased by 0.74, 0.69, 0.62, and 0.22 times, respectively (all p< 0.05) (Figure 4A,C)." 3177 3672 W4386601127.pdf 6 17 separator 0.97025526 ¶ 3672 3674 W4386601127.pdf 6 18 text 0.9996 "On day 42, SiO 2exposure upregulated TNF- a,IL-1b,MCP-1 , and TGF- b1mRNA expression levels in the lung tissues of mice by 3.94, 10.23, 63.59, and 1.83-fold, respectively, compared with the control group (all p< 0.05). By comparing the expression levels of inflammatory factors on the 7th and 42nd days, it was discovered that, except TNF- a, the enhanced expression of IL-1b,MCP-1 , and TGF- b1mRNA on day 42 after SiO 2exposure were more significant than those on day 7. In the Tet intervention group compared to the SiO 2group, the expression TNF- a,IL-1b,MCP-1 , and TGF- b1mRNA was downregulated by 0.84, 0.71, 0.70, and 0.57 times, respectively (all p< 0.05) (Figure 4B,C)." 3674 4366 W4386601127.pdf 6 0 paratext 0.97108924 330 0 3 W4210681436.pdf 2 1 separator 0.9942446 ¶ 3 5 W4210681436.pdf 2 2 text 0.9979543 "The remaining six patients were all found to have temporal lobe foci and anti-convulsant medication was introduced with therapeutic effect in four cases. Further investigation of one of these patients also revealed the presence of a cerebral aneurysm." 5 265 W4210681436.pdf 2 3 separator 0.9951581 ¶ 265 267 W4210681436.pdf 2 4 title 0.840716 Comment 267 275 W4210681436.pdf 2 5 separator 0.9928876 ¶ 275 277 W4210681436.pdf 2 6 text 0.999493 "A number of methodological flaws are apparent in the present study. Because of its retrospective nature it has not been possible to eliminate several sources of bias. For instance, the neurophysiologist reporting the EEGs was already informed of clinical details and must have made his interpretations with these in mind. This was inevitable, as the intention was to assess the significance of EEG recordings in clinical psychiatric practice." 277 736 W4210681436.pdf 2 7 separator 0.8024234 ¶ 736 738 W4210681436.pdf 2 8 text 0.99949116 "The nature of the sample studied must also be borne in mind; the present study cannot be regarded as a random survey of psychiatric patients. They were selected by the referring psychiatrist on the grounds of his suspecting or needing to eliminate the presence of organic cerebral disorder." 738 1039 W4210681436.pdf 2 9 separator 0.99006915 ¶ 1039 1041 W4210681436.pdf 2 10 text 0.99908924 "The percentage of abnormal recordings warrants some comment. Non-specific abnormalities have been reported in 5-10% of normal subjects and in up to 26% of psychoneurotic patients. Of our sample, 29% had an abnormal recording and half of these had a specific abnormality. Even the equivocal recordings demonstrated abnormality in excess of the non-specific increase in thcta activity described by Williams.8" 1041 1464 W4210681436.pdf 2 11 separator 0.99020815 ¶ 1464 1466 W4210681436.pdf 2 12 text 0.99962217 "Not surprisingly there is a reliable associationbetween abnormal EEG recordings and 'organic' factors in the history, mental state and neurological examination. Similarly, there is evidence that the psychiatrists could accurately predict what the EEG recordings would be (Table III). However, it should not be assumed that such accuracy implies that referrals were appropriate, as a large proportion of accurate predictions were of normal recordings." 1466 1931 W4210681436.pdf 2 13 separator 0.9827504 ¶ 1931 1933 W4210681436.pdf 2 14 text 0.9886088 "The clinical value of the EEG is reflected not by the proportion of abnormal recordings but by theinfluence of the recordings on the patient's manage ment, diagnosis and prognosis. Table IV shows that management, diagnosis and prognosis were influenced in 13.2% of cases. This is comparable with the usefulness of the CT scanner in psychiatry,Roberts & Lishman9 having found that the CT scanner influenced diagnosis, management and/or prognosis in 11.7% of patients scanned for clinical reasons.Bulletin of the Royal" 1933 2466 W4210681436.pdf 2 15 title 0.6816794 College of Psychiatrists 2466 2491 W4210681436.pdf 2 16 separator 0.9944187 ¶ 2491 2493 W4210681436.pdf 2 17 text 0.99951476 "A review of the literature by the authors revealed only one previous study that quantifies the clinicalusefulnessoftheEEG.Colgan&Philpott'°examined the results of 49 elderly patients referred on clinical grounds for EEG. Whilst 75.5% of recordings were abnormal, only 2% influenced future clinical practice." 2493 2812 W4210681436.pdf 2 18 separator 0.98443675 ¶ 2812 2814 W4210681436.pdf 2 19 text 0.9996501 "We would argue that the EEG does have a place in clinical psychiatric practice, but only in selected patients. Our findings suggest that the cost-effective ness of the EEG in psychiatry would be improved ifrecordings were limited to patients with 'organic' fac tors or in whom the referring psychiatrist anticipated an abnormal recording. However, we do not feel that the significance of these findings is high enough to exclude the usefulness of the EEG in the clinicalsetting when 'organic' factors and the psychiatrist's expectations are absent. Indeed, some may argue that the EEG is more useful when the abnormality is completely unexpected." 2814 3481 W4210681436.pdf 2 20 separator 0.99576885 ¶ 3481 3483 W4210681436.pdf 2 21 title 0.9476787 References 3483 3494 W4210681436.pdf 2 22 separator 0.9933603 ¶ 3494 3496 W4210681436.pdf 2 23 bibliography 0.9976882 "'FENTON,G. W., TENNENT. T. G., FENWICK, P. B. C. & RATTRAY. N. (1974)The EEG in anti-social behaviour: a study of posterior temporal slow activity in special hospital patients. Psychological Medicine,4, 181-186." 3496 3714 W4210681436.pdf 2 24 separator 0.9517006 ¶ 3714 3716 W4210681436.pdf 2 25 bibliography 0.99774694 "2HowARD,R. C. (1984)The clinical EEG and personality in mentally abnormal offenders. Psychological Medicine, 14, 569-580." 3716 3842 W4210681436.pdf 2 26 separator 0.9670688 ¶ 3842 3844 W4210681436.pdf 2 27 bibliography 0.9974853 "3GnuHLE, H. (I936) Wahn Ãœberden bei Epilepsie. Zeitschrift fÃ1⁄4r die Gesamte, Neurologie und Psvchialrie, 154,395-399." 3844 3967 W4210681436.pdf 2 28 separator 0.94855094 ¶ 3967 3969 W4210681436.pdf 2 29 bibliography 0.9976511 "*HILL, J. D. N. (1953) Psychiatrie aspects of epilepsy. Medical Press, 229,473-475." 3969 4055 W4210681436.pdf 2 30 separator 0.95134425 ¶ 4055 4057 W4210681436.pdf 2 31 bibliography 0.99768347 "5PoND,D. A. (1957) Psychiatric aspects of epilepsy. Journal of the Indian Medica! Profession. 3, 1441 1451.6SLATER. E., BEARD. A. W. & CLITHEROE, E. (1963) The schizophrenia-like psychosis of epilepsy. British Journal of Psychiatry, 109,95 150.7FLOR-HENRY, P. (1969) Psychosis and temporal lobe epilepsy. Epilepsia, 10, 363 395.8WILLIAMS. D. (1941) The significance of an abnormal electro-encephalogram. Journal of Neurology and Psvchiatn-, 4,257-268." 4057 4521 W4210681436.pdf 2 32 separator 0.97589934 ¶ 4521 4523 W4210681436.pdf 2 33 bibliography 0.9979383 """ROBERTS. J. K. A. & LISHMAN, W. A. (1984) The use of the CAT head scanner in clinical psychiatry. British Journal of Psychiatry. 145, 152-158." 4523 4671 W4210681436.pdf 2 34 separator 0.9818397 ¶ 4671 4673 W4210681436.pdf 2 35 bibliography 0.9978027 "10CoLGAN, J. & PHILPOTT. M. (1985) The routine use of investigations in elderly psychiatric patients. Age and Ageing. 14,163 167." 4673 4807 W4210681436.pdf 2 36 separator 0.94629467 ¶ 4807 4809 W4210681436.pdf 2 37 paratext 0.6920805 "A detailed lisi of references is available from the authors on request.https://doi.org/10.1192/S014007890002099X Published online by Cambridge University Press" 4809 4972 W4210681436.pdf 2 0 paratext 0.98721147 Al-Adab Journal – No. 135 ( December ) 2020 / 1442 0 64 W3112971779.pdf 9 1 separator 0.596405 ¶ 66 68 W3112971779.pdf 9 2 paratext 0.96530926 42 68 71 W3112971779.pdf 9 3 title 0.96150345 "Table 7. Respondents’ perceptions on choosing to study tourism major" 71 143 W3112971779.pdf 9 4 separator 0.98676795 ¶ 145 147 W3112971779.pdf 9 5 text 0.99393386 "Table 8 demonstrates the positive perceptions of the respondents to work in the tourism industry in the future (mean vale of 4.20). They are happy to choose tourism as a career path (4.23), plan to work in the industry after graduation (4.24), and will do their utmost to get a pr ofession in the tourism sector (4.16)." 147 480 W3112971779.pdf 9 6 separator 0.9961679 ¶ 482 484 W3112971779.pdf 9 7 title 0.87559223 "Table 8. Respondents’ perceptions on career intention/ commitment to work in tourism" 484 572 W3112971779.pdf 9 8 separator 0.99339986 ¶ 574 576 W3112971779.pdf 9 9 title 0.98587227 Measurement Model 576 594 W3112971779.pdf 9 10 separator 0.9920449 ¶ 596 598 W3112971779.pdf 9 11 text 0.9976229 "The measurement model looks at the validity and reliability of the measurement scale. It examines the relationships between indicators and their relevant constructs. Conducting the SEM analysis using the WarpPLS Software program (Ver. 7), the measurement model showed good model fit indices according to (Kock, 2020 ):" 598 929 W3112971779.pdf 9 12 separator 0.67784494 ¶ 930 932 W3112971779.pdf 9 13 text 0.5708888 Average path coefficient (APC)=0.233 932 969 W3112971779.pdf 9 14 math 0.46707916 , 969 970 W3112971779.pdf 9 15 text 0.4851278 P<0.001, average R -squared ¶ 970 1001 W3112971779.pdf 9 16 math 0.47559404 (ARS)=0. 1001 1010 W3112971779.pdf 9 17 text 0.44061536 727 1010 1013 W3112971779.pdf 9 18 math 0.51123 , P<0.00 1013 1021 W3112971779.pdf 9 19 text 0.47148174 1, 1021 1025 W3112971779.pdf 9 20 math 0.4509197 average 1025 1032 W3112971779.pdf 9 21 text 0.4739059 adjusted 1032 1041 W3112971779.pdf 9 22 math 0.45735514 R -squared 1041 1052 W3112971779.pdf 9 23 text 0.44000965 ( 1052 1054 W3112971779.pdf 9 24 math 0.48275772 AARS)=0.720, 1054 1066 W3112971779.pdf 9 25 text 0.52666706 ¶ P<0.001, average block VIF (AVIF) 1067 1103 W3112971779.pdf 9 26 math 0.44024718 =2 1103 1105 W3112971779.pdf 9 27 text 0.5216696 .497 ( 1105 1111 W3112971779.pdf 9 28 math 0.43656546 ideal 1111 1116 W3112971779.pdf 9 29 text 0.66048205 "), average full collinearity VIF (AFVIF)=2.521 (ideal), Tenenhaus GoF (GoF)=0.707 (large), Sympson's paradox ratio (SPR)=0.833 (acceptable), R -squared contribution ra tio (RSCR)=0.937 (acceptable), statistical suppression ratio (SSR)=1 (acceptable), and Nonlinear bivariate causality direction ratio (NLBCDR)=1 (acceptable). enter Compared to other fields, it is easy to study this field" 1116 1527 W3112971779.pdf 9 30 table 0.9243164 "4.29 .832 Study" 1527 1546 W3112971779.pdf 9 31 text 0.6099393 ing 1546 1550 W3112971779.pdf 9 32 table 0.5146157 tourism 1550 1557 W3112971779.pdf 9 33 text 0.6801779 major in university was 1557 1581 W3112971779.pdf 9 34 table 0.5958888 1581 1582 W3112971779.pdf 9 35 text 0.6664569 a 1582 1583 W3112971779.pdf 9 36 table 0.6033602 ¶ 1584 1586 W3112971779.pdf 9 37 text 0.6197561 correct decision 1586 1603 W3112971779.pdf 9 38 table 0.915905 "4.20 .883 Grand mean 3.99 Career intention/ commitment to work in tourism Mean Std. Deviation I am very happy to have chosen tourism as a career path 4.23 .852 I intend to work in the tourism industry after graduation. 4.24 .839 I would like to work in the tourism industry after graduation 4.22 .849 I see my vocational (professional) future in the tourism industry 4.17 .810 I will do my best to acquire a job in the tourism industry 4.16 .893 Grand mean 4.20" 1604 2122 W3112971779.pdf 9 0 title 0.9725374 Goals of the Bioavailability Ratio (BR) 0 39 W3185215762.pdf 10 1 separator 0.99433565 ¶ 39 41 W3185215762.pdf 10 2 text 0.97406447 "Addresses two key points: 1)Provides a formal way of quantifying variance in contaminant partitioning 2)Translating bioavailability among phases relevant for contaminant characterization: Cfree, Ctotal, Clipid" 41 263 W3185215762.pdf 10 3 separator 0.9941652 ¶ 263 265 W3185215762.pdf 10 0 paratext 0.9771744 "532 Rev. Ciênc. Méd. Biol., Salvador, v.12, especial, p.531-534, dez.2013Jo" 0 77 W936227339.pdf 1 1 title 0.5575305 a 77 78 W936227339.pdf 1 2 text 0.9912893 "quim Custódio da Silva Júnior e Helton Estrela Ramossister had hyperthyroidism secondary to Graves’ disease some years ago, and was successfully treated with radi - oiodine. At admission, he had normal blood pressure (110/70 mmHg), a normal-high resting pulse rate (95 beats per minute), and a respiratory rate of 22 incursions per minute. On physical examination, the main finding was a loss of muscular strength at legs (grade 1/5) and arms (grade 2/5). The laboratorial profile have showed an important hypokalemia (1.7 mmol/L, normal range 3.5-5.1 mmol/L), a discrete hypophosphatemia (1.6 mmol/L, normal range 2.5-4.5 mmol/L) and a normal- low magnesemia (1.6 mmol/L, normal range 1.6-2.3 mmol/L). The serum levels of sodium and calcium were at normal ranges. The arterial blood gasometry didn’t show acid-base alteration. There was also an elevation of the total bilirubin (4.3 mg/dL, normal range 0.2-1.3 mg/dL) and the creatine phosphokinase (CPK) levels (566 U/L, normal range 55-170 U/L). The myocardial injury specific markers CK-MB (creatine kinase-myocardial band) and troponin were normal. The electrocardiogram presented a right bundle branch block, with a sinusal rhythm. The axial computed tomography of the brain was normal." 78 1387 W936227339.pdf 1 3 separator 0.95013607 ¶ 1387 1389 W936227339.pdf 1 4 text 0.9991539 "An intravenous drip with 20 mEq/L of potassium chloride diluted in saline (0.9% sodium chloride solution) was started, and the patient was transferred to the In - tensive Care Unit of the Hospital. A normalization of se - rum potassium levels to 3.8 mmol/L was associated with an important improvement of the muscular weakness, allowing the patient to walk with the help of an assistant 12 hours after the start of the drip." 1389 1833 W936227339.pdf 1 5 separator 0.96561396 ¶ 1834 1836 W936227339.pdf 1 6 text 0.9995999 "The Endocrinology team of was called to investi - gate the etiology of the electrolyte disturbance. At his first analysis, the Endocrinologist (J.C.S.Jr.) noted a nor - mal heart-beat rhythm (72 beats per minute), and no alterations at blood pressure, or respiratory rate. The patient had a subtle ocular proptosis (not measured) and, at neck palpation, the thyroid gland was enlarged (twice the normal volume), but no pain and nodules were observed." 1836 2306 W936227339.pdf 1 7 separator 0.8674722 ¶ 2306 2308 W936227339.pdf 1 8 text 0.9997018 "The thyroid function tests confirmed thyrotoxico - sis, with a suppressed TSH level (TSH < 0.02 mUI/L), as - sociated with elevated total T4 of 24.2 ng/dL (Table 1). A thyroid ultrasound revealed an augmented gland (20.8 cm3 of volume, normal range until 15 cm3), with no nod - ules." 2308 2604 W936227339.pdf 1 9 separator 0.9465988 ¶ 2604 2606 W936227339.pdf 1 10 text 0.9995924 "Thyrotoxicosis treatment was promptly started with propylthiouracil 300 mg per day (100 mg three times a day), prednisone 20 mg per day and propranolol 40 mg twice a day. The patient was followed for more five days at hospital, with a satisfactory clinical evolution. At dis - charge, he was oriented to maintain use of propylthioura - cil 100 mg three times a day and propranolol 40 mg twice a day; the corticosteroid was stopped. He was advised to stop the regular consumption of sugar-rich diet." 2606 3127 W936227339.pdf 1 11 separator 0.9703876 ¶ 3127 3129 W936227339.pdf 1 12 text 0.99968016 "Thirty days after the onset of the symptoms, the patient returned for consultation, with thyroid function tests showing a great response to anti-thyroid drugs (see Table 1). The TRAb (thyroid stimulating hormone receptor antibody) value was 4.5 UI/L (normal range: below 1.75 UI/L). Following the recommendation of most recent guidelines3, we have changed the anti-thyroid drug to me - thimazole 10 mg once a day. Due to a slow heart beat (56 beats per minute), propranolol dose was reduced to 20 mg twice a day." 3129 3668 W936227339.pdf 1 13 separator 0.9660975 ¶ 3668 3670 W936227339.pdf 1 14 text 0.9995428 "In the follow-up, 4 months after the diagnosis of hyperthyroidism, the patient referred absence of symp - toms of thyrotoxicosis and no recurrence of muscle weak - ness (see Table 1 to view the laboratory profile). Patient refused treatment with radioiodine at this moment due concern about infertility. The methimazole dose was maintained with recommendation of return each 3 months (or before, if symptoms recurrency)." 3670 4110 W936227339.pdf 1 15 separator 0.9967196 ¶ 4110 4112 W936227339.pdf 1 16 title 0.9459099 Table 1. Laboratorial findings. 4112 4144 W936227339.pdf 1 17 separator 0.9970194 ¶ 4144 4146 W936227339.pdf 1 0 paratext 0.92642826 "Tinjaua n Pengetahuan Perekam Medis dan Informasi Kesehatan Mengenai Aturan Penggunaan ICD 10 dalam Menentukan Diagnosa di RS Bhayangkara TK II Sartika Asi h Bandung Jurnal Health Sains, Vol . 2, No . 8, Agustus 2021 1019" 0 297 W3193635244.pdf 5 1 separator 0.98260725 ¶ 299 301 W3193635244.pdf 5 2 title 0.98974454 B. Pembahasan 302 316 W3193635244.pdf 5 3 separator 0.989082 ¶ 318 320 W3193635244.pdf 5 4 title 0.9390567 Tabel 3 320 328 W3193635244.pdf 5 5 separator 0.81126934 ¶ 330 332 W3193635244.pdf 5 6 table 0.97970855 "Uji Hipotesis Chi Square pernyataan kuesioner X1 tentang aturan -aturan ICD Chi Square df Asymp Sig X1.1 12,800a 1 ,000 X1.2 9,800a 1 ,002 X1.3 1,800a 1 ,180 X1.4 ,000a 1 1,000 X1.5 5,000a 1 ,025 X1.6 5,000a 2 ,026 Total_X1 7,300b 2 ,026" 332 608 W3193635244.pdf 5 7 separator 0.98695964 ¶ ¶ 609 615 W3193635244.pdf 5 8 text 0.9556135 "1. Berdasarkan pernyataan ke 1 “saya telah memahami dagge r dan asterisk” yang menjawab “ya” itu sebanyak 90% dan yang menjawab “tidak” sebanyak 10% " 615 778 W3193635244.pdf 5 9 separator 0.67333215 ¶ 778 779 W3193635244.pdf 5 10 text 0.966669 "2. Berdasarkan pernyataan ke 2 “saya bisa menentukan lead term dengan tepat sesuai dengan ICD 10” yang menjawab “ya” sebanyak 85% dan yang menjawab “tidak” sebanyak 15% " 779 963 W3193635244.pdf 5 11 separator 0.6721917 ¶ 963 964 W3193635244.pdf 5 12 text 0.97064877 "3. Berda sarkan pernyataan ke 3 “saya telah memahami tentang cara pemakaian exclude atau include pada ICD 10” yang menjawab “ya” sebanyak 65% dan yang menjawab “tidak” 35%" 964 1151 W3193635244.pdf 5 13 separator 0.7126739 ¶ 1153 1155 W3193635244.pdf 5 14 text 0.97696537 "4. Berdasarkan pernyataan ke 4 “saya mampu memahami perbedaan dari setiap Rule MB” yang me njawab “ya” sebanyak 50% dan yang menjawab “tidak” sebanyak 50%" 1155 1323 W3193635244.pdf 5 15 separator 0.66987133 ¶ 1325 1327 W3193635244.pdf 5 16 text 0.9821188 "5. Berdasarkan pernyataan ke 5 “saya bisa membedakan kondisi utama (main condition) dan kondisi lain (other condition)” yang menjawab “ya” sebanyak 75% dan yang menjawab “tidak” 25% 6. Berdasarkan p ernyat aan ke 6 “saya seorang koder dan saya telah memahami arti Parentheses” yang menjawab “ya” sebanyak 75% dan yang menjawab “tidak” sebanyak 25%" 1327 1703 W3193635244.pdf 5 17 separator 0.8556949 ¶ ¶ 1705 1711 W3193635244.pdf 5 18 text 0.9973074 "Hasil penelitian setelah dilakukan uji Chi Square Test mendapatkan nilai p sebesar 0,026 sehingga p <0,05." 1711 1824 W3193635244.pdf 5 19 separator 0.9710937 ¶ 1825 1827 W3193635244.pdf 5 20 text 0.99541837 "Berdas arkan uji statistik dapat ditemukan bahwa ada hubungan yang signifikan antara aturan -aturan ICD -10 dengan pengetahuan Perekam Medis dan Informasi Kesehatan" 1827 2004 W3193635244.pdf 5 21 separator 0.8433522 ¶ 2006 2008 W3193635244.pdf 5 22 text 0.9970467 "Sehingga dapat disimpulkan bahwa latar belakang pendidikan berperan dalam menunjang pengetahua n yang dibutuhkan seorang Perekam Medis dan Informasi Kesehatan untuk menghasilkan kode yang akurat, hal ini dikarenakan:" 2008 2241 W3193635244.pdf 5 23 separator 0.86645365 ¶ 2243 2245 W3193635244.pdf 5 24 text 0.96092135 "1. Dasar ilmu yang didapatkan akan mendukung dalam mencari kode 2. Mencocokan obat serta tindakan yang diberikan 3. Mencocokan tulisan dokter d engan kode diagnosa yang berada di ICD -10 dan kode tindakan yang berada di ICD - 9-CM." 2245 2499 W3193635244.pdf 5 25 separator 0.85943013 "¶ ¶ ¶" 2500 2518 W3193635244.pdf 5 26 title 0.62510765 Tabel 4 2518 2526 W3193635244.pdf 5 0 paratext 0.98860765 Transport Policy 134 (2023) 119–127 0 35 W4320730775.pdf 6 1 separator 0.97730666 ¶ 35 37 W4320730775.pdf 6 2 text 0.9993704 "125manufacturing industries, together with low specialisation in faster growing industries. Prior research has also argued that an element of the productivity problem in Wales links to the relatively low number of SMEs identified as having high growth prospects, with this entailing low rates of business evolution from small into medium-sized firms (Eco- nomic Intelligence Wales, 2019). While these productivity differences have proven to be persistent, the case evidence in this paper suggests that infrastructure development and resulting innovation between managing contractors and their local suppliers (particularly SME sup- pliers) and the new growth opportunities that arise, could play a role in improving productivity growth. The wider effects identified in this paper suggest that the total regional gains resulting from the infra- structure development will exceed those direct and indirect impacts estimated in the previous section." 37 1020 W4320730775.pdf 6 3 separator 0.99550235 ¶ 1021 1023 W4320730775.pdf 6 4 title 0.9866702 6.Discussion 1023 1036 W4320730775.pdf 6 5 separator 0.99579895 ¶ 1037 1039 W4320730775.pdf 6 6 text 0.9997524 "It was argued at the outset that transport appraisal approaches typically focus on end user benefits of new or improved infrastructure or provide a snapshot of expected or actual gains in the periods leading up to, and after, the project’s construction stage. However, this paper ar- gues for closer monitoring of in-process benefits. While the monitoring outlined in the paper primarily provided a longitudinal tracking of im- pacts to the local economy, in particular focusing on labour market gains, sectoral support and supply chain legacies, these gains may not be merely short term, temporarily transferred from another area or obscured by externalities (Laird and Venables, 2017; SACTRA, 1999)." 1039 1766 W4320730775.pdf 6 7 separator 0.91945815 ¶ 1767 1769 W4320730775.pdf 6 8 text 0.9997454 "Instead, these in-process economic gains contribute to longer-term regional economic development that is particularly pertinent for lag- ging regions. In the A465 case, evidence of benefits dispersing across the economy was found, from a spillover of output and GVA gains that can spur productivity, through to labour market benefits, an upskilling of the labour force and the development of sustainable collaborations along supply chains and across sectors." 1769 2245 W4320730775.pdf 6 9 separator 0.9747132 ¶ 2246 2248 W4320730775.pdf 6 10 text 0.9997328 "In practical terms socio-economic outcomes in road transport appraisal processes remain undervalued (Atkins et al., 2017) and largely overlook the in-process benefits (Laird and Venables, 2017). While cost-benefit analysis ex ante and ex post remain important it is often too procedural (Kelly et al., 2015; Odeck and Kjerkreit, 2019), disconnected from supply side improvements (Mullen and Marsden, 2015), affected by optimism bias (Flyvbjerg, 2007, 2009) and with a challenge to con- nect it with in-process analysis. While studies might focus on the com- parison between ex ante and ex post analyses (see Kelly et al., 2015) the explicit consideration of in-process benefits is often omitted. Moreover, the scarcity of in-process evaluations creates mistrust over account - ability, with a potential for those possessing knowledge of the system to maximise the gaps in the appraisal process and highlight only the favourable outcomes (Flyvbjerg et al., 2016). Incorporating periodic reviews during the lifetime of the infrastructure projects provides greater transparency, allows for in-process comparisons to be made with similar infrastructure projects and incorporates real-time reporting from sources directly impacted by the project. By more fully connecting ex ante claims with ex post outcomes, in-process reporting may help to reduce the tendency towards ‘survival of the unfittest’ in terms of future infrastructure projects." 2248 3743 W4320730775.pdf 6 11 separator 0.9687345 ¶ 3744 3746 W4320730775.pdf 6 12 text 0.9997252 "Despite scepticism over the construction sector’s low-value proper - ties and propensity to market volatility (Angulo et al., 2018; Lagravi - nese, 2015), this paper points to the overlooked benefits of long-term infrastructure projects when building sectoral specialisation and struc- ture of the region. Potential benefits can be realised by monitoring and building on the socio-economic benefits during the in-process stage and supporting these benefits into the ex post stage. This study points to the advancements of wider economic gains during the course of the con- struction and operations phases (i.e., design, development, build and handover), establishing collaborations, expertise and expansion oppor - tunities that transcend the life of the project itself. While the completed infrastructure is seen to provide productivity and competitiveness ben- efits (Love et al., 2016; Mullen and Marsden, 2015) this paper highlights the importance of the ‘in-process’ activities for augmenting existing sectoral and labour market components, therefore helping to support lagging economies." 3746 4876 W4320730775.pdf 6 13 separator 0.97501016 ¶ 4877 4879 W4320730775.pdf 6 14 text 0.9996271 "The mixed methods analysis and periodic design of the analysis captured the accumulating effects in real time, monitoring how these expand across the time-horizon (seven years) studied and identifying legacy effects for regions and the businesses and workers within them." 4879 5160 W4320730775.pdf 6 15 separator 0.6006381 ¶ 5161 5163 W4320730775.pdf 6 16 text 0.9996488 "The method then facilitated the identification of the wider regional gains that cannot be fully captured though the quantitative modelled impact analysis. This paper begins to demonstrate that monitoring de- velopments provides a better understanding of how, and to what extent, transportation schemes can bring more unexpected benefits. The process by which lessons and competencies are collaboratively attained, shared and fostered may help to support the development of indirect knowledge spillovers across the local economy (Steen and Hansen, 2014; Qui et al., 2017). As the findings from this study also suggest, these knowledge spillovers bring with them opportunities for longer-term incremental innovation for firms across the local supply chain (Hervas-Oliver et al., 2019; McCann and Simonen, 2005; Morrissey and Cummins, 2016). This study then contributes to an overlooked aspect of transport planning and policy, illustrating how the in-process operations and construction ac- tivities can encourage and embed subsequent and longer-term socio- - economic outcomes for regions." 5163 6294 W4320730775.pdf 6 17 separator 0.9668325 ¶ 6295 6297 W4320730775.pdf 6 18 text 0.999662 "The case considered in this paper also illustrates that systematically monitoring socio-economic impacts during the course of a development ensures greater transparency (Flyvbjerg et al., 2016; Penyalver et al., 2019), identification of potentially additional economic outcomes, accountability and continuity in measurement of outcomes. This would facilitate an orderly progression towards the factors that might also be considered in the ex post analysis of wider user benefits of the new infrastructure." 6297 6824 W4320730775.pdf 6 19 separator 0.9965042 ¶ 6825 6827 W4320730775.pdf 6 20 title 0.99192494 7.Limitations and future research 6827 6861 W4320730775.pdf 6 21 separator 0.99551105 ¶ 6862 6864 W4320730775.pdf 6 22 text 0.9932044 "The paper is not without some limitations. For example, while it addresses potential localised externalities advanced during the in- process operations and activities, there is still scope for follow-up research to more fully understand how these network and innovative gains might vary depending on firm and regional characteristics. Moreover, the specific Welsh policy context towards the encouragement of in-process benefits may restrict generalisation of the findings to other places." 6864 7374 W4320730775.pdf 6 23 separator 0.7593206 ¶ 7375 7377 W4320730775.pdf 6 24 text 0.99974036 "It is also noted that the economic modelling framework has limita - tions, not least in terms of embracing changes to the supply side of the economy caused by the road development process. Aside from the standard assumptions, the analysis also took no account of the nature of project financing and its source, and that impacts may vary according to the procurement model adopted. The Input-Output framework does not identify opportunity costs associated with the public spending. To re- dress these types of problems and better understand the complex regional effects associated with construction shock, displacement and financing variations, a computable general equilibrium model would be a more appropriate methodological tool (Kim et al., 2011; Rokicki et al., 2021). However, while the limitations to the Input-Output model are accepted, this paper does use a combination of data sources and cases to support and unpack claims, combining a focus on the periodic assess - ment of economic benefits understood through the framework of an economic model but then supported and supplemented through quali - tative case studies. In doing so, the paper reveals that a better under - standing and structuring of in-process benefits of infrastructure improvements is important for a more holistic appraisal of impact." 7377 8742 W4320730775.pdf 6 25 separator 0.99062717 ¶ 8743 8745 W4320730775.pdf 6 26 text 0.9988901 "There is a final question on the extent to which the effects described in this paper apply to other major infrastructure projects in Wales (and elsewhere). The effects and issues discussed in the paper are considered M. Munday et al." 8745 8985 W4320730775.pdf 6 0 paratext 0.8609533 "STEP KONFERENCE 2022 ¶ 2 ¶" 0 36 W4286383164.pdf 1 1 separator 0.9843597 ¶ 38 40 W4286383164.pdf 1 2 text 0.94874936 "ekspеrtiza qilish va хatarni bahоlash tizimini takоmillashtirish, krеditlar bo’yicha muammоli qarzlarning hоsil bo’lishiga yo’l qo’ymaslik bоrasida оldini оlish chоralarini ko’rish yo’ li bilan tijоrat banklarining krеdit pоrtfеli muttasil o’sishi hamda sifati yaхshilanishini ta’minlash 2011 –2015 yillarda rеspublika mоliya - bank tizimini yanada islоh qilish va barqarоrligini оshirishning ustuvоr yo’nalishlaridan biri sifatida bеlgilab bеr ilgan edi." 40 510 W4286383164.pdf 1 3 separator 0.9905618 ¶ 512 514 W4286383164.pdf 1 4 text 0.9981063 "O’zbеkistоn Rеspublikasida banklar bank оpеratsiyalarini amalga оshirishga dоir qarоrlar qabul qilishda mustaqil bo’lib, o’rnatilgan tartibda krеdit siyosatini ishlab chiqadi va amalga оshiradi. Bank krеdit siyosatining maqsadi krеditlash jaray onida amaldagi qоnunchilik talablari va mе’yorlariga riоya etish, krеdit siyosati va krеditlash tartiblarining bir хilligini kafоlatlash, tavakkalchiliklarni muntazam ravishda divеrsifikatsiyalash, bank krеdit pоrtfеli sifatini yaхshilash va krеditlash jarayonini to’g’ri amalga оshirish оrqali bank faоliyatining fоydaliligi va samaradоrligini ta’minlashdan ibоrat." 514 1147 W4286383164.pdf 1 5 separator 0.98639727 ¶ 1149 1151 W4286383164.pdf 1 6 text 0.99938285 "Mamlakatimiz tijоrat banklarida krеdit pоrtfеlini shakllantirish va krеdit siyosatini ishlab chiqishda samarali ishlar amalga оshirilib kеlinmоq da natijada biz yuqоrida ko’rsatib, tahlil qilib o’tgan muvaffaqiyatlarga erishilmоqda. Ammо shunday bo’lishiga qaramasdan bank krеdit pоrtfеli muntazam ravishda tahlil va audit qilib bоrish lоzimligi qоnunchilikda bеlgilab bеrilgan. Bunda asоsiy e’tibоr ajratilayotgan krеditni sifat jihatdan ko’rib chiqish bilan birga krеditlash jarayonini bоshqarish sifatini bahоlash, jumladan, tasdiqlangan krеdit siyosatiga va krеdit hujjatlarini rasmiylashtirish jarayonlariga, garоvni rasmiylashtirish va bahоlash, krеdi tlashga dоir vakоlatlarni taqsimlash, qоnunchilik mе’yorlariga riоya qilishga muvоfiqligini ta’minlashga qaratilishi lоzim." 1151 1960 W4286383164.pdf 1 7 separator 0.9919676 ¶ 1962 1964 W4286383164.pdf 1 8 text 0.99660045 "Bugungi kunda Respublikamizda iqtisodiyotni rivojlantirishga yo‘naltirilgan bank kreditlari hajmining oshishi, bank kreditlaridan fo ydalanayotgan turli mulkchilik va xo‘jalik yuritish shaklidagi mijozlar miqdori ko‘payishi va banklar tomonidan" 1964 2215 W4286383164.pdf 1 0 paratext 0.6582023 This is a self-archived version of an original article 0 54 W4366987338.pdf 0 1 text 0.5599225 . This version 54 70 W4366987338.pdf 0 2 separator 0.42211974 ¶ 70 71 W4366987338.pdf 0 3 text 0.57894045 may differ from the original in pagination and typographic details. 71 139 W4366987338.pdf 0 4 separator 0.99556977 ¶ 140 142 W4366987338.pdf 0 5 paratext 0.42750806 Author(s): 142 153 W4366987338.pdf 0 6 separator 0.7944373 ¶ 154 156 W4366987338.pdf 0 7 paratext 0.25635883 Title: 156 163 W4366987338.pdf 0 8 separator 0.3368746 164 165 W4366987338.pdf 0 9 table 0.39210862 ¶ 165 166 W4366987338.pdf 0 10 paratext 0.2771145 Year: 166 172 W4366987338.pdf 0 11 table 0.46812612 ¶ 173 175 W4366987338.pdf 0 12 paratext 0.3167735 Version: 175 184 W4366987338.pdf 0 13 separator 0.41976747 ¶ 184 186 W4366987338.pdf 0 14 paratext 0.337879 Copyright: 186 197 W4366987338.pdf 0 15 separator 0.2912495 ¶ 197 199 W4366987338.pdf 0 16 paratext 0.48556948 Rights 199 206 W4366987338.pdf 0 17 text 0.32430777 : 206 207 W4366987338.pdf 0 18 separator 0.30093253 ¶ 207 209 W4366987338.pdf 0 19 paratext 0.72911847 "Rights url: Please cite the original version: CC BY 4.0 https://creativecommons.org/licenses/by/4.0/" 209 317 W4366987338.pdf 0 20 separator 0.99169844 ¶ 317 319 W4366987338.pdf 0 21 title 0.98508537 "Teachers’ occupational well-being in relation to teacher–student interactions at the lower secondary school level" 319 435 W4366987338.pdf 0 22 separator 0.96267354 ¶ 435 437 W4366987338.pdf 0 23 paratext 0.949048 "© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group Published version" 437 546 W4366987338.pdf 0 24 separator 0.98634946 ¶ 546 548 W4366987338.pdf 0 25 bibliography 0.99637145 Chan, Sze Wah; Pöysä, Sanni; Lerkkanen, Marja-Kristiina; Pakarinen, Eija 548 621 W4366987338.pdf 0 26 separator 0.77046 ¶ 621 623 W4366987338.pdf 0 27 bibliography 0.9971184 "Chan, S. W., Pöysä, S., Lerkkanen, M.-K., & Pakarinen, E. (2023). Teachers’ occupational well- being in relation to teacher–student interactions at the lower secondary school level." 623 807 W4366987338.pdf 0 28 separator 0.62360907 ¶ 807 809 W4366987338.pdf 0 29 bibliography 0.99263126 Scandinavian Journal of Educational Research, Early online. 809 869 W4366987338.pdf 0 30 separator 0.638478 ¶ 869 871 W4366987338.pdf 0 31 bibliography 0.81224984 https://doi.org/10.1080/00313831.2023.2204114 871 917 W4366987338.pdf 0 32 separator 0.9757519 ¶ 917 919 W4366987338.pdf 0 33 paratext 0.94441897 2023 919 924 W4366987338.pdf 0 0 bibliography 0.9963109 "Tietze R, Schreiber E, Lyer S, Alexiou C. Mitoxantrone loaded superparamagnetic nanoparticles for drug targeting: a versatile and sensitive method for quantification of drug enrichment in rabbit tissues using HPLC -UV. J Biomed Biotechnol. 2010;2010:597304." 0 265 W2139870539.pdf 1 1 separator 0.98725295 ¶ 267 269 W2139870539.pdf 1 2 bibliography 0.9957086 "Tietze R, Lyer S, Durr S, Struffert T, Engelhorn T, Schwarz M, Eckert E, Goen T, Vasylyev S, Peukert W, Wiekhorst F, Trahms L, Dorfler A, Alexiou C. 2013 . Efficient drug -delivery using magnetic nanoparticles --biodistribution and therapeutic effects in tumour bearing rabbits." 269 554 W2139870539.pdf 1 3 separator 0.8705687 ¶ 555 557 W2139870539.pdf 1 4 bibliography 0.98198634 Nanomedicine 9:961 -971 557 581 W2139870539.pdf 1 5 separator 0.9383418 "¶ ¶ ¶" 582 600 W2139870539.pdf 1 0 title 0.9257879 8 Abstract and Applied Analysis 0 31 W2086495114.pdf 7 1 separator 0.9503845 ¶ 31 33 W2086495114.pdf 7 2 math 0.9571599 "×τμρ]p(τ)p(ρ)󵄨󵄨󵄨󵄨H(τ,ρ)󵄨󵄨󵄨󵄨dτdρ ≤t−α−β−γ−δ−2(μ+ ])󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩st Γ(α)Γ(γ) ×∫∫t 0τμρ](t−τ)α−1(t−ρ)γ−1 ×2F1(α+β+μ,−η;α;1−τ t) ×2F1(γ+δ+ ],−ζ;γ;1−ρ t)p(τ)p(ρ)dτdρ ≤󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩stIα,β,η,μ t{p(t)}Iγ,δ,ζ, ] t{p(t)}, (37)" 33 297 W2086495114.pdf 7 3 separator 0.43684095 ¶ 297 299 W2086495114.pdf 7 4 text 0.87752825 whichcompletestheproofof Theorem5 . 299 335 W2086495114.pdf 7 5 separator 0.93320525 ¶ 335 337 W2086495114.pdf 7 6 text 0.6689766 Remark 6. Forγ=α,δ 337 356 W2086495114.pdf 7 7 math 0.5207454 = 356 357 W2086495114.pdf 7 8 text 0.5771752 β,ζ 357 360 W2086495114.pdf 7 9 math 0.47622332 = 360 361 W2086495114.pdf 7 10 text 0.63748085 "η,a n d ]=μ,Theorem5 immediatelyreducesto Theorem4 ." 361 415 W2086495114.pdf 7 11 separator 0.994846 ¶ 415 417 W2086495114.pdf 7 12 title 0.99159086 3. Consequent Results and Special Cases 417 457 W2086495114.pdf 7 13 separator 0.99468315 ¶ 457 459 W2086495114.pdf 7 14 text 0.9815631 "As implications of our main results, we consider some consequentresultsofTheorems 4and5bysuitablychoosing the function p(t).T ot h i se n d ,l e tu ss e t p(t) = tλ(λ ∈ [ 0 , ∞ ) , t∈( 0 , ∞ ) ) ;t h e n ,o nu s i n g( 10), Theorems 4and5 yieldthefollowingresults." 459 732 W2086495114.pdf 7 15 separator 0.97860014 ¶ 732 734 W2086495114.pdf 7 16 text 0.8049457 Corollary 7. Letfandgbe two synchronous functions on ¶ 734 789 W2086495114.pdf 7 17 math 0.5342637 [0,∞ 789 794 W2086495114.pdf 7 18 text 0.51470447 ). 794 796 W2086495114.pdf 7 19 math 0.47961646 I 796 798 W2086495114.pdf 7 20 text 0.4866042 ff󸀠 798 801 W2086495114.pdf 7 21 math 0.537864 ∈Lr 801 804 W2086495114.pdf 7 22 text 0.49636218 ([ 804 806 W2086495114.pdf 7 23 math 0.46906167 0 806 807 W2086495114.pdf 7 24 text 0.5048207 ,∞)),g󸀠 807 814 W2086495114.pdf 7 25 math 0.5174619 ∈Ls([0 814 820 W2086495114.pdf 7 26 text 0.5053433 ,∞ 820 822 W2086495114.pdf 7 27 math 0.94304657 ")),r>1,r−1+s−1= 1,then 2󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨Γ(μ+λ+1)Γ(λ+1−β+η) Γ(λ+1−β)Γ(λ+μ+1+α+η) ×tλ−β−μIα,β,η,μ t{tλf(t)g(t)} −Iα,β,η,μ t{tλf(t)}Iα,β,η,μ t{tλg(t)}󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨 ≤t−2α−2β−4μ󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩s Γ2(α) ×∫∫t 0τμ+λρμ+λ(t−τ)α−1(t−ρ)α−1 ×2F1(α+β+μ,−η;α;1−τ t) ×2F1(α+β+μ,−η;α;1−ρ t)󵄨󵄨󵄨󵄨τ−ρ󵄨󵄨󵄨󵄨dτdρ ≤󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩sΓ2(μ+λ+1)Γ2(λ+1−β+η)t1+2λ−2β−2μ Γ2(λ+1−β)Γ2(μ+λ+1+α+η), (38) wheret>0,β<1,μ>−1,α>max{0,−β−μ} ,β−1<η<0 , λ≥0,min(λ+μ,λ−β+η)>−1 ." 822 1303 W2086495114.pdf 7 28 text 0.70880586 Corollary 8. Letfandgbe two synchronous functions on ¶ 1303 1357 W2086495114.pdf 7 29 math 0.5304464 [0,∞).I ff 1357 1368 W2086495114.pdf 7 30 text 0.47732154 󸀠 1368 1369 W2086495114.pdf 7 31 math 0.9366488 "∈Lr([0,∞)),g󸀠∈Ls([0,∞)),r>1,r−1+s−1= 1,then 󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨Γ(μ+λ+1)Γ(λ+1−β+η) Γ(λ+1−β)Γ(μ+λ+1+α+η) ×tλ−β−μIγ,δ,ζ, ] t{tλf(t)g(t)} +Γ(]+λ+1)Γ(λ+1−δ+ζ ) Γ(λ+1−δ)Γ(]+λ+1+γ+ζ)tλ−δ− ] ×Iα,β,η,μ t{tλf(t)g(t)} −Iα,β,η,μ t{tλf(t)}Iγ,δ,ζ, ] t{tλg(t)} −Iγ,δ,ζ, ] t{tλf(t)}Iα,β,η,μ t{tλg(t)}󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨 ≤t−α−β−γ−δ−2μ−2 ]󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩s Γ(α)Γ(γ) ×∫∫t 0(t−τ)α−1(t−ρ)γ−1 2F1(α+β+μ,−η;α;1−τ t) ×2F1(γ+δ+ ],−ζ;γ;1−ρ t)τμ+λρ]+λ󵄨󵄨󵄨󵄨τ−ρ󵄨󵄨󵄨󵄨dτdρ ≤󵄩󵄩󵄩󵄩󵄩f󸀠󵄩󵄩󵄩󵄩󵄩r󵄩󵄩󵄩󵄩󵄩g󸀠󵄩󵄩󵄩󵄩󵄩s ×(Γ(μ+λ+1)Γ (]+λ+1) ×Γ(λ+1−β+η)Γ (λ+1−δ+ζ )) ×(Γ(λ+1−β)Γ(μ+λ+1+α+η) ×Γ(λ+1−δ)Γ( ]+λ+1+γ+ζ))−1 ×t1+2λ−β−δ−2μ−2 ], (39) forallt>0,β<1,μ>−1,α>max{0,−β−μ} ,β−1<η<0 , δ<1,]>− 1,γ>max{0,−δ− ]},δ−1<ζ<0 ,λ≥0, min(λ+μ,λ+ ],λ−β+η,λ−δ+ζ)>−1 ." 1369 2122 W2086495114.pdf 7 32 separator 0.71291524 ¶ 2122 2124 W2086495114.pdf 7 33 text 0.94518393 "Further, if we put λ=0inCorollaries 7and8(orp(t) = 1in Theorems 4and5), we obtain the following integral inequalities." 2124 2247 W2086495114.pdf 7 34 separator 0.98191726 ¶ 2247 2249 W2086495114.pdf 7 35 text 0.76097524 Corollary 9. Letfandgbe two synchronous functions on 2249 2303 W2086495114.pdf 7 36 separator 0.4572869 ¶ 2303 2304 W2086495114.pdf 7 37 math 0.5338326 [0, 2304 2308 W2086495114.pdf 7 38 text 0.5065308 ∞). 2308 2311 W2086495114.pdf 7 39 math 0.4643848 I 2311 2312 W2086495114.pdf 7 40 text 0.5068047 ff󸀠 2312 2316 W2086495114.pdf 7 41 math 0.50737274 ∈Lr([0 2316 2322 W2086495114.pdf 7 42 text 0.4874146 ,∞ 2322 2324 W2086495114.pdf 7 43 math 0.87238014 ")),g󸀠∈Ls([0,∞)),r>1,r−1+s−1= 1,then 2󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨Γ(μ+1)Γ(1−β+η) Γ(1−β)Γ(μ+1+α+η)t−β−μIα,β,η,μ t{f(t)g(t)} −Iα,β,η,μ t{f(t)}Iα,β,η,μ t{g(t)}󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨󵄨" 2324 2483 W2086495114.pdf 7 0 paratext 0.9880687 Int. J. Environ. Res. Public Health 2017 ,14, 459 11 of 14 0 58 W2609223890.pdf 10 1 separator 0.9914001 ¶ 58 60 W2609223890.pdf 10 2 text 0.99407583 "entitlement gaps among less targeted population groups, such as adults and/or more disadvantaged migratory status groups, such as irregular migrants, is needed. At the same time, more efforts such as development of online immunization registries and the promotion of cooperation between countries of origin, transit and destination, should be encouraged in order to share immunization strategies and monitor administered vaccines. The finalization, sharing and dissemination of the pilot projects mentioned above [ 47–49] could represent useful steps to track the health status of migrants and refugees, establishing mechanisms of collaboration among countries. This could guarantee appropriate and targeted health assistance for migrants/refugees and facilitate cross-border immunization planning. Furthermore, effective health status monitoring can also lead to avoiding unnecessary health actions, including unnecessary re-vaccination." 60 1016 W2609223890.pdf 10 3 separator 0.9949815 ¶ 1016 1018 W2609223890.pdf 10 4 text 0.92205864 "Acknowledgments: The authors would like to thank all the members of the “Network for the Control of Cross-border Health Threats in the Mediterranean Basin and Black Sea for the ProVacMed project” for filling out the questionnaires and for their comments to the paper: Albania: Erida Nelaj, Silvia Bino, Iria Preza " 1018 1336 W2609223890.pdf 10 5 contact 0.4958815 ¶ 1336 1337 W2609223890.pdf 10 6 text 0.8162819 (Institute of Public Health, Tirana 1337 1373 W2609223890.pdf 10 7 contact 0.43672866 ); 1373 1375 W2609223890.pdf 10 8 text 0.5562061 1375 1376 W2609223890.pdf 10 9 contact 0.49974006 Algeria: 1376 1384 W2609223890.pdf 10 10 text 0.4749575 Karima 1384 1391 W2609223890.pdf 10 11 contact 0.46837875 Meziani ( 1391 1401 W2609223890.pdf 10 12 text 0.52291065 Institut 1401 1409 W2609223890.pdf 10 13 contact 0.43116194 National 1409 1418 W2609223890.pdf 10 14 text 0.48207727 de Sant 1418 1427 W2609223890.pdf 10 15 contact 0.53262985 éPub 1427 1431 W2609223890.pdf 10 16 text 0.49764153 lique, 1431 1437 W2609223890.pdf 10 17 contact 0.4507645 Algeria); ¶ 1437 1449 W2609223890.pdf 10 18 text 0.5596609 Armenia: Gayane Sahakyan (Ministry of Health, 1449 1495 W2609223890.pdf 10 19 contact 0.37152708 Republic 1495 1504 W2609223890.pdf 10 20 text 0.37279922 of 1504 1507 W2609223890.pdf 10 21 contact 0.54628396 Armenia), Marine 1507 1524 W2609223890.pdf 10 22 text 0.44348255 Kirakosyan 1524 1535 W2609223890.pdf 10 23 contact 0.41800904 (National Center 1535 1552 W2609223890.pdf 10 24 table 0.47789145 1552 1553 W2609223890.pdf 10 25 contact 0.43751737 ¶ of Disease Control and Prevention 1553 1588 W2609223890.pdf 10 26 text 0.40998712 , Republic of 1588 1601 W2609223890.pdf 10 27 contact 0.46455145 Armenia); Bosnia and Herzegovina: Dusan 1601 1641 W2609223890.pdf 10 28 text 0.43685967 Kojic 1641 1647 W2609223890.pdf 10 29 contact 0.42379844 (Ministry of 1647 1660 W2609223890.pdf 10 30 table 0.42880642 1660 1661 W2609223890.pdf 10 31 contact 0.44975346 ¶ Civil Affairs, 1661 1677 W2609223890.pdf 10 32 text 0.5197683 Sarajevo 1677 1686 W2609223890.pdf 10 33 contact 0.44353005 ), Jel 1686 1692 W2609223890.pdf 10 34 text 0.40774763 a 1692 1693 W2609223890.pdf 10 35 contact 0.5507825 A ́ cim 1693 1700 W2609223890.pdf 10 36 text 0.40568322 ovi 1700 1703 W2609223890.pdf 10 37 contact 0.5112509 ́ c (Public Health Institute of Republic of Srpska), 1703 1755 W2609223890.pdf 10 38 text 0.48263204 San 1755 1759 W2609223890.pdf 10 39 contact 0.4566659 jin Musa (Public Health 1759 1782 W2609223890.pdf 10 40 table 0.40379256 1782 1783 W2609223890.pdf 10 41 contact 0.4332632 ¶ Institute of 1783 1797 W2609223890.pdf 10 42 text 0.37431708 Federation 1797 1808 W2609223890.pdf 10 43 contact 0.50754464 of B&H); 1808 1817 W2609223890.pdf 10 44 text 0.33834636 Egypt 1817 1823 W2609223890.pdf 10 45 table 0.34814444 : 1823 1824 W2609223890.pdf 10 46 text 0.4157648 Shaza Badr 1824 1835 W2609223890.pdf 10 47 contact 0.37209576 , 1835 1836 W2609223890.pdf 10 48 text 0.39757377 E 1836 1838 W2609223890.pdf 10 49 contact 0.41164923 hab Basha (Ministry 1838 1857 W2609223890.pdf 10 50 text 0.38084227 of 1857 1860 W2609223890.pdf 10 51 contact 0.3831461 Health and 1860 1871 W2609223890.pdf 10 52 text 0.41809595 Population, Egypt 1871 1889 W2609223890.pdf 10 53 contact 0.5484139 ); 1889 1891 W2609223890.pdf 10 54 separator 0.3943783 ¶ 1891 1893 W2609223890.pdf 10 55 table 0.3498461 Georgia 1893 1901 W2609223890.pdf 10 56 contact 0.42800307 : Anna 1901 1907 W2609223890.pdf 10 57 text 0.45239845 Tatulashvili (National Center for Disease 1907 1949 W2609223890.pdf 10 58 table 0.34861645 Control and 1949 1961 W2609223890.pdf 10 59 text 0.37816948 Public Health, Georgia 1961 1984 W2609223890.pdf 10 60 contact 0.449468 ); 1984 1986 W2609223890.pdf 10 61 text 0.37276143 Israel 1986 1993 W2609223890.pdf 10 62 table 0.33533183 : 1993 1994 W2609223890.pdf 10 63 contact 0.49049187 Itamar 1994 2001 W2609223890.pdf 10 64 table 0.40865514 ¶ 2001 2003 W2609223890.pdf 10 65 contact 0.49427554 Grot 2003 2008 W2609223890.pdf 10 66 text 0.39617938 to, 2008 2011 W2609223890.pdf 10 67 contact 0.36764312 Emilia 2011 2018 W2609223890.pdf 10 68 text 0.42826754 Anis, Larisa 2018 2031 W2609223890.pdf 10 69 table 0.33077866 Mo 2031 2034 W2609223890.pdf 10 70 text 0.33136988 irman 2034 2039 W2609223890.pdf 10 71 table 0.42349792 , 2039 2040 W2609223890.pdf 10 72 text 0.37944815 No 2040 2043 W2609223890.pdf 10 73 table 0.38193637 a 2043 2044 W2609223890.pdf 10 74 contact 0.38331866 Ce 2044 2047 W2609223890.pdf 10 75 text 0.43723118 dar 2047 2050 W2609223890.pdf 10 76 table 0.37143457 (Ministry 2050 2060 W2609223890.pdf 10 77 text 0.4111508 of Health, Israel 2060 2078 W2609223890.pdf 10 78 table 0.39526975 ); Jordan: 2078 2088 W2609223890.pdf 10 79 contact 0.36043447 Ratib Surour ( 2088 2103 W2609223890.pdf 10 80 text 0.3760712 Ministry of 2103 2114 W2609223890.pdf 10 81 table 0.50196916 ¶ 2114 2116 W2609223890.pdf 10 82 text 0.3559064 Health 2116 2123 W2609223890.pdf 10 83 table 0.33941898 , 2123 2124 W2609223890.pdf 10 84 text 0.39632553 Jordan 2124 2131 W2609223890.pdf 10 85 contact 0.39823335 ); 2131 2133 W2609223890.pdf 10 86 table 0.38804752 2133 2134 W2609223890.pdf 10 87 text 0.35404417 Kosovo 2134 2140 W2609223890.pdf 10 88 table 0.43590966 : 2140 2141 W2609223890.pdf 10 89 contact 0.34632564 Isme Hu 2141 2149 W2609223890.pdf 10 90 text 0.3381041 molli 2149 2154 W2609223890.pdf 10 91 table 0.4576671 , 2154 2155 W2609223890.pdf 10 92 contact 0.2987692 Ari 2155 2159 W2609223890.pdf 10 93 table 0.37812346 jana 2159 2163 W2609223890.pdf 10 94 contact 0.34758478 Kala 2163 2168 W2609223890.pdf 10 95 text 0.31196 vesh 2168 2172 W2609223890.pdf 10 96 table 0.36350077 i, Naser 2172 2180 W2609223890.pdf 10 97 contact 0.42182615 Ramadani 2180 2189 W2609223890.pdf 10 98 table 0.3649919 , Luljeta Gashi 2189 2204 W2609223890.pdf 10 99 contact 0.36635792 ( 2204 2206 W2609223890.pdf 10 100 table 0.42880934 National Institute ¶ 2206 2226 W2609223890.pdf 10 101 contact 0.36728063 of 2226 2229 W2609223890.pdf 10 102 table 0.3657698 Public 2229 2236 W2609223890.pdf 10 103 contact 0.37720433 Health of Kosovo); 2236 2255 W2609223890.pdf 10 104 table 0.3822118 Republic 2255 2264 W2609223890.pdf 10 105 text 0.3651023 of Macedonia 2264 2277 W2609223890.pdf 10 106 contact 0.4296989 - 2277 2278 W2609223890.pdf 10 107 text 0.45285437 FYROM: Blagoja Aleksoski, 2278 2304 W2609223890.pdf 10 108 contact 0.3306477 Kristina 2304 2312 W2609223890.pdf 10 109 text 0.52189976 Stavridis 2312 2322 W2609223890.pdf 10 110 contact 0.41047055 , Vladimir 2322 2332 W2609223890.pdf 10 111 table 0.4268648 ¶ 2332 2334 W2609223890.pdf 10 112 contact 0.40647665 Miki 2334 2339 W2609223890.pdf 10 113 text 0.300878 c 2339 2340 W2609223890.pdf 10 114 contact 0.36330765 ( 2340 2342 W2609223890.pdf 10 115 text 0.37803832 Institute of Public Health 2342 2368 W2609223890.pdf 10 116 contact 0.46849123 of R. Macedonia); 2368 2386 W2609223890.pdf 10 117 table 0.29581878 2386 2387 W2609223890.pdf 10 118 text 0.3652441 Moldova 2387 2394 W2609223890.pdf 10 119 contact 0.4163603 : 2394 2395 W2609223890.pdf 10 120 text 0.4179348 Melnic 2395 2403 W2609223890.pdf 10 121 contact 0.41462883 Anatolie ( 2403 2413 W2609223890.pdf 10 122 text 0.5098183 National Center for Public Health 2413 2446 W2609223890.pdf 10 123 contact 0.39878568 , ¶ 2446 2449 W2609223890.pdf 10 124 text 0.49203148 Republic of 2449 2462 W2609223890.pdf 10 125 contact 0.46946457 Moldova); 2462 2471 W2609223890.pdf 10 126 text 0.44554794 Palestine 2471 2481 W2609223890.pdf 10 127 contact 0.4336512 : 2481 2482 W2609223890.pdf 10 128 text 0.56671333 Sbehat Wesam 2482 2495 W2609223890.pdf 10 129 contact 0.4455166 ( 2495 2497 W2609223890.pdf 10 130 text 0.47293314 Palestinian Ministry of 2497 2520 W2609223890.pdf 10 131 contact 0.44905972 Health); 2520 2529 W2609223890.pdf 10 132 text 0.41364953 Serbia 2529 2536 W2609223890.pdf 10 133 contact 0.509778 : 2536 2537 W2609223890.pdf 10 134 text 0.44811937 Gor 2537 2541 W2609223890.pdf 10 135 contact 0.42932153 anka 2541 2545 W2609223890.pdf 10 136 text 0.5057785 Loncare 2545 2553 W2609223890.pdf 10 137 contact 0.40553534 "vic (" 2553 2560 W2609223890.pdf 10 138 text 0.52803725 Institute of Public Health of 2560 2589 W2609223890.pdf 10 139 contact 0.41923216 Serbia 2589 2596 W2609223890.pdf 10 140 text 0.5706555 , Belgrade); Ukraine: Olga Lugash (State Sanitary and Epidemiological 2596 2665 W2609223890.pdf 10 141 contact 0.45806193 Service ¶ 2665 2675 W2609223890.pdf 10 142 text 0.40669113 of 2675 2678 W2609223890.pdf 10 143 contact 0.45016694 Ukraine 2678 2686 W2609223890.pdf 10 144 text 0.90089345 "),Mariya Iemets (Ministry of Health of Ukraine); Tunisia: Kais Guezmir, Essia Ben Farhat Hmida (Minist ère de la Sant é, Tunisie). The ProVacMed project was implemented with a financial support of the Italian Ministry of Health (DG Communication and International relations)—Euromed-UpM Projects. We would like to thank Pasqualino Rossi and Maria Grazia Pompa, scientific referents for the project at the Italian Ministry of Health." 2686 3124 W2609223890.pdf 10 145 separator 0.9969757 ¶ 3124 3126 W2609223890.pdf 10 146 title 0.680054 Author Contributions 3126 3147 W2609223890.pdf 10 147 text 0.9903948 ": All authors contributed substantially to the conception of the work. Cristina Giambi, Maria Grazia Dente, Christian Napoli, and Silvia Declich conceived and designed the study. Cristina Giambi, Maria Grazia Dente, Christian Napoli, Carmen Montaño-Remacha, Flavia Riccardo and Silvia Declich participated in the development of the questionnaire. Cristina Giambi collected the data with the survey tool. Cristina Giambi and Martina Del Manso analyzed the data. Cristina Giambi wrote the preliminary paper. Martina Del Manso, Maria Grazia Dente, Christian Napoli, Carmen Montaño-Remacha, Flavia Riccardo and Silvia Declich critically revised the preliminary paper. The “Network for the control of cross-border health threats in the Mediterranean Basin and Black Sea for the ProVacMed project” filled out the questionnaires and critically revised the preliminary paper. All the authors read and approved the final version of the manuscript." 3147 4099 W2609223890.pdf 10 148 separator 0.9955952 ¶ 4099 4101 W2609223890.pdf 10 149 title 0.7589105 Conflicts of Interest 4101 4122 W2609223890.pdf 10 150 text 0.7792473 : The authors declare no conflict of interest. 4122 4167 W2609223890.pdf 10 151 separator 0.9957493 ¶ 4167 4169 W2609223890.pdf 10 152 title 0.9566829 References 4169 4180 W2609223890.pdf 10 153 separator 0.9909036 ¶ 4180 4182 W2609223890.pdf 10 154 bibliography 0.94358623 "1. WHO Regional Office for Europe. Migration and Health: Key Issues. Available online: http://www.euro.who.int/en/health-topics/health-determinants/migration-and-health/migrant- health-in-the-european-region/migration-and-health-key-issues (accessed on 17 January 2017)." 4182 4456 W2609223890.pdf 10 155 separator 0.9805449 ¶ 4456 4458 W2609223890.pdf 10 156 bibliography 0.6852649 "2. European Centre for Disease Prevention and Control. Expert Opinion on the Public Health Needs of Irregular Migrants, Refugees or Asylum Seekers across the EU’s Southern and South-Eastern Borders." 4458 4659 W2609223890.pdf 10 157 separator 0.74861634 ¶ 4659 4661 W2609223890.pdf 10 158 bibliography 0.9347985 "Available online: http://ecdc.europa.eu/en/publications/Publications/Expert-opinion-irregular-migrants- public-health-needs-Sept-2015.pdf (accessed on 17 January 2017)." 4661 4832 W2609223890.pdf 10 159 separator 0.9902649 ¶ 4832 4834 W2609223890.pdf 10 160 bibliography 0.9372185 "3. European Centre for Disease Prevention and Control. Handbook on Using the ECDC Preparedness Checklist Tool to Strengthen Preparedness against Communicable Disease Outbreaks at Migrant Reception/Detention Centres. Available online: http://ecdc.europa.eu/en/publications/Publications/preparedness-checklist- migrant-centres-tool.pdf (accessed on 17 January 2017)." 4834 5205 W2609223890.pdf 10 161 separator 0.9848616 ¶ 5205 5207 W2609223890.pdf 10 162 bibliography 0.97796994 "4. European Centre for Disease Prevention and Control. Migrant Health: Background Note to the ‘ECDC Report on Migration and Infectious Diseases in the EU’. Available online: http://ecdc.europa.eu/en/ publications/Publications/0907_TER_Migrant_health_Background_note.pdf (accessed on 17 January 2017)." 5207 5512 W2609223890.pdf 10 0 paratext 0.93627965 66 0 2 W3129501402.pdf 7 1 separator 0.9867598 ¶ 3 5 W3129501402.pdf 7 2 title 0.50195646 8 9 W3129501402.pdf 7 3 table 0.95024145 "Composite Reliability Asosiasi 0.836217 Brand Awarness 0.791416 Brand Image 0.837010 Kualitas 0.834623 Loyalitas 0.801159 ¶" 9 159 W3129501402.pdf 7 4 separator 0.8914843 ¶ ¶ 161 167 W3129501402.pdf 7 5 text 0.9902033 "Pada tabel composit Reabilitas menunjukan bahwa nilai tertinggi dari 0.7 adalah pada Asosiasi sebesar 0.836217 , diikuti Brand image 0.837010 , Kualitas 0.834623 dan yang terakhir sebesar 0.801159 pada variabel Loyalitas ." 168 401 W3129501402.pdf 7 6 separator 0.94298494 ¶ 402 404 W3129501402.pdf 7 7 text 0.9801359 "Berdasarkan hasil olahan data , menunjukkan semua indikator -indikat or memiliki nilai t -statistiknya > 1.96, yang berarti bahwa semua indikator tersebut mempunyai nilai yang signifikan. Nilai terbesar pada indikator Brand awareness A2 dengan nilai tertinggi 16.120321 “varian Produk akademik program studi ”. Varian merup akan pilihan yang akan diambil calon konsumen ketika mempertimbangkan apa yang diinginkan sesuai keinginan pasar dan kesesuian lingkup pekerjaannya . Berikutnya adalah komponen P1 dengan nilai tertinggi 23.923621 Sistem registrasi canggih, akurat dan terkini”. Pada persepsi kualitas yaitu penguatan pada infrastruktuk teknologi informasi yang mumpuni yang dapat membantu dengan cepat proses kinerja “.Brand Asosiasi berikutnya adalah Persepsi Kualitas P 4 dengan nilai sedang 21.228227 “Petugas pelma memba ntu mahasiswa dalam memberi informasi lain ”. Hal ini berkaitan dengan pelayanan prima untuk memuaskan konsumen, petugas selalu berempati kepada pelangganya dan peningkatan kinerjanya selalu ditingkatkan." 404 1493 W3129501402.pdf 7 8 separator 0.9944393 ¶ ¶ 1495 1501 W3129501402.pdf 7 9 title 0.9839042 Tabel Path Coefficients 1501 1525 W3129501402.pdf 7 10 separator 0.8837145 ¶ 1527 1529 W3129501402.pdf 7 11 table 0.9883382 "Original Sample (O) Sample Mean (M) Standard Deviation (STDEV) Standard Error (STERR) T Statistics (|O/STERR|) Brand Image -> Asosiasi 0.542219 0.554723 0.050603 0.050603 10.715180 Brand Image -> Brand Awarness 0.676286 0.688073 0.053062 0.053062 12.745171 Brand Image -> Kualitas 0.566994 0.578823 0.057474 0.057474 9.865272 Brand Image -> Loyalitas 0.396499 0.410436 0.070223 0.070223 5.646275" 1531 1996 W3129501402.pdf 7 12 separator 0.9022614 ¶ ¶ 1998 2004 W3129501402.pdf 7 13 text 0.98901385 "Berdasarkan tabel Path Coefficients dapat dilihat bahwa tiga parameter jalur hubungan yang menjadi hipotesa pada penelitian ini bernilai t -statistiknya > 1.96 yang menunjukkan signifikansi pengaruh antar variabel laten sebagai berikut :" 2004 2248 W3129501402.pdf 7 0 paratext 0.96429497 "BioMed Central Page 1 of 19" 0 29 W2148643489.pdf 0 1 separator 0.5227455 ¶ 29 31 W2148643489.pdf 0 2 paratext 0.90633 "(page number not for citation purposes)Retrovirology Open Access Research" 31 107 W2148643489.pdf 0 3 separator 0.8424617 ¶ 107 109 W2148643489.pdf 0 4 title 0.99044997 "Effect of SWI/SNF chromatin remodeling complex on HIV-1 Tat activated transcription" 109 196 W2148643489.pdf 0 5 separator 0.99041724 ¶ 196 198 W2148643489.pdf 0 6 contact 0.9922373 "Emmanuel Agbottah1, Longwen Deng1, Luke O Dannenberg1, Anne Pumfery2 and Fatah Kashanchi*1,3" 198 294 W2148643489.pdf 0 7 separator 0.69187486 ¶ 294 296 W2148643489.pdf 0 8 contact 0.99283046 "Address: 1The George Washington University Medical Center, Department of Biochemistry and Molecular Biol ogy, Washington, DC 20037, USA, 2Seton Hall University, Department of Bi ology, South Orange, NJ 07079, USA and 3The Institute for Genomic Research (TIGR), Rockville, MD 20850, USA" 296 589 W2148643489.pdf 0 9 separator 0.8742888 ¶ 589 591 W2148643489.pdf 0 10 contact 0.99340695 "Email: Emmanuel Agbottah - etagbottah@yahoo .com; Longwen Deng - bcmfxk@gwumc.edu; Lu ke O Dannenberg - dannenbergl@yahoo.com; Anne Pumfery - pumferan@shu.edu; Fa tah Kashanchi* - bcmfxk@gwumc.edu * Corresponding author" 591 816 W2148643489.pdf 0 11 separator 0.98794895 ¶ 820 822 W2148643489.pdf 0 12 title 0.9045889 Abstract 822 831 W2148643489.pdf 0 13 separator 0.9944803 ¶ 831 833 W2148643489.pdf 0 14 text 0.9953998 "Background: Human immunodeficiency virus type 1 (HIV-1 ) is the etiologic agent of acquired immunodeficiency virus (AIDS). Fo llowing entry into the host ce ll, the viral RNA is reverse transcribed into DNA and subsequently integrated into the host genome as a chromatin template. The integrated proviral DNA, along with the specific chromatinized environment in which integration takes place allows for the coordinated regulation of vi ral transcription and replication." 833 1314 W2148643489.pdf 0 15 separator 0.548865 ¶ 1314 1316 W2148643489.pdf 0 16 text 0.99960554 "While the specific roles of and interplay between viral and host proteins have not been fully elucidated, numerous reports indicate that HIV-1 retains the ability for self-regulation via the pleiotropic effects of it s viral proteins. Though viral transc ription is fully dependent upon host cellular factors and the state of host activation , recent findings indica te a complex interplay between viral proteins and host transcription regu latory machineries includ ing histone deacetylases (HDACs), histone acetyltransferases (HATs), cyclin dependent kinases (CDKs), and histone methyltransferases (HMTs)." 1316 1937 W2148643489.pdf 0 17 separator 0.97713387 ¶ 1937 1939 W2148643489.pdf 0 18 text 0.9997088 "Results: Here, we describe the effect of Ta t activated transcription at the G1/S border of the cell cycle and analyze the interaction of modified Ta t with the chromatin remodeling complex, SWI/ SNF. HIV-1 LTR DNA reconstituted in to nucleosomes can be activated in vitro using various Tat expressing extracts. Optimally activate d transcription was observed at the G1/S border of the cell cycle both in vitro and in vivo , where chromatin remodeling comple x, SWI/SNF, was present on the immobilized LTR DNA. Using a number of in vitro binding as well as in vivo chromatin immunoprecipitation (ChIP) assays , we detected the presence of both BRG1 and acetylated Tat in the same complex. Finally , we demonstrate that activated transcription resulted in partial or complete removal of the nucleosome from the star t site of the LTR as evidenced by a restriction enzyme accessibility assay." 1939 2848 W2148643489.pdf 0 19 separator 0.9118185 ¶ 2848 2850 W2148643489.pdf 0 20 text 0.99947715 "Conclusion: We propose a model where unmodified Tat is involved in binding to the CBP/p300 and cdk9/cyclin T1 complexes facilitating transcription init iation. Acetylated Tat dissociates from the TAR RNA structure and recruits bromodomai n-binding chromatin modifying complexes such as p/CAF and SWI/SNF to possibly facilitate transcription elongation." 2850 3210 W2148643489.pdf 0 21 paratext 0.968974 Published: 07 August 2006 3210 3235 W2148643489.pdf 0 22 separator 0.9108354 ¶ 3235 3237 W2148643489.pdf 0 23 paratext 0.9759731 "Retrovirology 2006, 3:48 doi:10.1186/1742-4690-3-48Received: 13 June 2006 Accepted: 07 August 2006 This article is available from: http ://www.retrovirology.com/content/3/1/48" 3237 3418 W2148643489.pdf 0 24 separator 0.5246378 ¶ 3418 3420 W2148643489.pdf 0 25 paratext 0.97529954 © 2006 Agbottah et al; licensee BioMed Central Ltd. 3420 3472 W2148643489.pdf 0 26 separator 0.5087806 3472 3473 W2148643489.pdf 0 27 paratext 0.9607146 "¶ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons. org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the orig inal work is properly cited." 3473 3753 W2148643489.pdf 0 0 paratext 0.9225979 "International Journal of AerospaceEngineering Hindawi Publishing Corporation http://www.hindawi.com Volume 2010" 0 117 W1997356566.pdf 8 1 separator 0.9734615 ¶ 117 119 W1997356566.pdf 8 2 contact 0.32637733 RoboticsJournal of 119 138 W1997356566.pdf 8 3 table 0.36076802 ¶ 138 140 W1997356566.pdf 8 4 contact 0.27123767 Hindawi Publishing Corporation 140 171 W1997356566.pdf 8 5 table 0.35129517 ¶ 171 173 W1997356566.pdf 8 6 contact 0.29014847 http 173 178 W1997356566.pdf 8 7 table 0.26063636 :// 178 181 W1997356566.pdf 8 8 contact 0.26619917 www 181 184 W1997356566.pdf 8 9 paratext 0.31431544 . 184 185 W1997356566.pdf 8 10 contact 0.3383014 hindawi.com Volume 2014 185 208 W1997356566.pdf 8 11 separator 0.7640101 ¶ 208 210 W1997356566.pdf 8 12 contact 0.5167936 Hindawi Publishing Corporation 210 241 W1997356566.pdf 8 13 paratext 0.32618874 241 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contact 0.4184114 "Hindawi Publishing Corporation http://www.hindawi.com" 799 855 W1997356566.pdf 8 45 table 0.437866 Volume 2014Shock and Vibration ¶ 855 888 W1997356566.pdf 8 46 bibliography 0.42590255 Hindawi Publishing Corporation 888 919 W1997356566.pdf 8 47 table 0.46032414 ¶ 919 921 W1997356566.pdf 8 48 bibliography 0.4609975 http://www 921 932 W1997356566.pdf 8 49 table 0.4194752 . 932 933 W1997356566.pdf 8 50 bibliography 0.4124586 hindawi.com 933 944 W1997356566.pdf 8 51 table 0.5140709 "Volume 2014Civil EngineeringAdvances in Acoustics and VibrationAdvances" 944 1018 W1997356566.pdf 8 52 bibliography 0.45381433 in 1018 1021 W1997356566.pdf 8 53 table 0.43414104 ¶ 1021 1023 W1997356566.pdf 8 54 bibliography 0.43928295 Hindawi 1023 1031 W1997356566.pdf 8 55 table 0.42420882 Publishing 1031 1042 W1997356566.pdf 8 56 bibliography 0.42230976 Corporation 1042 1054 W1997356566.pdf 8 57 table 0.44764185 ¶ 1054 1056 W1997356566.pdf 8 58 bibliography 0.42619884 http://www 1056 1067 W1997356566.pdf 8 59 table 0.44316995 . 1067 1068 W1997356566.pdf 8 60 bibliography 0.3964899 hindawi 1068 1075 W1997356566.pdf 8 61 table 0.39767212 . 1075 1076 W1997356566.pdf 8 62 bibliography 0.37042457 com 1076 1079 W1997356566.pdf 8 63 table 0.41341347 Volume 2014 1079 1091 W1997356566.pdf 8 64 separator 0.5440162 ¶ 1091 1093 W1997356566.pdf 8 65 contact 0.3905987 "Hindawi Publishing Corporation http://www.hindawi.com" 1093 1149 W1997356566.pdf 8 66 table 0.36844578 Volume 2014Electrical 1149 1171 W1997356566.pdf 8 67 title 0.41980174 and 1171 1175 W1997356566.pdf 8 68 table 0.50532097 "Computer EngineeringJournal of Advances in ¶" 1175 1225 W1997356566.pdf 8 69 bibliography 0.4146537 OptoElectronics 1225 1242 W1997356566.pdf 8 70 table 0.35077852 ¶ 1242 1243 W1997356566.pdf 8 71 bibliography 0.52842224 Hindawi Publishing Corporation 1243 1274 W1997356566.pdf 8 72 table 0.34207565 ¶ 1275 1277 W1997356566.pdf 8 73 bibliography 0.46271577 http://www 1277 1288 W1997356566.pdf 8 74 table 0.34093678 . 1288 1289 W1997356566.pdf 8 75 bibliography 0.3841345 hindawi.comVolume 1289 1306 W1997356566.pdf 8 76 table 0.2768959 2014 1306 1311 W1997356566.pdf 8 77 separator 0.97208273 ¶ 1311 1313 W1997356566.pdf 8 78 contact 0.3890022 The Scientific 1313 1328 W1997356566.pdf 8 79 table 0.36662927 ¶ 1330 1332 W1997356566.pdf 8 80 contact 0.32206985 World Journal 1332 1346 W1997356566.pdf 8 81 table 0.34296334 "¶ Hindawi Publishing Corporation http://" 1346 1390 W1997356566.pdf 8 82 title 0.23494548 www 1390 1393 W1997356566.pdf 8 83 table 0.28844082 . 1393 1394 W1997356566.pdf 8 84 title 0.2623058 hindawi 1394 1401 W1997356566.pdf 8 85 table 0.30073738 .com Volume 2014 1401 1417 W1997356566.pdf 8 86 separator 0.9121089 ¶ 1417 1419 W1997356566.pdf 8 87 bibliography 0.6794779 "SensorsJournal of Hindawi Publishing Corporation http://www.hindawi.com Volume 2014" 1419 1507 W1997356566.pdf 8 88 separator 0.69383895 ¶ 1507 1509 W1997356566.pdf 8 89 bibliography 0.40063632 Modell 1509 1516 W1997356566.pdf 8 90 table 0.4295175 ing & ¶ 1516 1524 W1997356566.pdf 8 91 bibliography 0.4137382 1524 1525 W1997356566.pdf 8 92 table 0.45108372 Simulation 1525 1535 W1997356566.pdf 8 93 bibliography 0.4218465 in Engineering 1535 1551 W1997356566.pdf 8 94 table 0.39282137 ¶ 1551 1552 W1997356566.pdf 8 95 bibliography 0.4636631 Hindawi Publishing Corporation 1552 1583 W1997356566.pdf 8 96 table 0.42819488 ¶ 1584 1586 W1997356566.pdf 8 97 bibliography 0.40007234 http://www 1586 1597 W1997356566.pdf 8 98 table 0.3980827 . 1597 1598 W1997356566.pdf 8 99 bibliography 0.36448386 hindawi.com 1598 1609 W1997356566.pdf 8 100 table 0.33895546 Volume 1609 1616 W1997356566.pdf 8 101 bibliography 0.32703078 2014 1616 1621 W1997356566.pdf 8 102 separator 0.6080878 ¶ 1621 1623 W1997356566.pdf 8 103 contact 0.37548947 "Hindawi Publishing Corporation http://www.hindawi.com" 1623 1679 W1997356566.pdf 8 104 bibliography 0.38856426 Volume 2014Chemical EngineeringInternational Journal of 1679 1735 W1997356566.pdf 8 105 separator 0.3204001 ¶ 1735 1737 W1997356566.pdf 8 106 bibliography 0.40452936 Antennas and 1738 1751 W1997356566.pdf 8 107 table 0.48113915 1751 1752 W1997356566.pdf 8 108 bibliography 0.6098303 "¶ PropagationInternational Journal of Hindawi Publishing Corporation http://www.hindawi.com Volume 2014" 1752 1859 W1997356566.pdf 8 109 separator 0.4605661 ¶ 1859 1861 W1997356566.pdf 8 110 bibliography 0.7333051 "Hindawi Publishing Corporation http://www.hindawi.com Volume 2014Navigation and ObservationInternational Journal of Hindawi Publishing Corporation http://www.hindawi.com Volume 2014Distributed Sensor NetworksInternational Journal of" 1861 2107 W1997356566.pdf 8 0 paratext 0.8927005 "ORIGINAL ARTICLEORIGINAL ARTICLE 39 SA JOURNAL OF RADIOLOGY • June 2009" 0 81 W1997885526.pdf 5 1 text 0.99004936 "pared with 44% in this study. Splenomegaly without focal masses is relatively common in the tropics and can have myriads of causes includ - ing malaria, septicaemia, typhoid, schistosomiasis, portal hypertension, haemolytic anaemia and tropical splenomegaly." 81 347 W1997885526.pdf 5 2 separator 0.9215381 ¶ 347 349 W1997885526.pdf 5 3 text 0.9993599 "Hepatomegaly is commonly attributed to either a non-specific response to infection, hepatitis, fatty change, or neoplastic infiltration from lymphoma or Kaposi’s sarcoma.11 However, hepatosplenomegaly in AIDS patients in the absence of hepatic focal lesions may suggest infection ( M. avium intracellulare , malaria or histoplasmosis) rather than lymphoma.12" 349 723 W1997885526.pdf 5 4 separator 0.97128534 ¶ 723 725 W1997885526.pdf 5 5 text 0.9995673 "Y ee et al.10 and Schneiderman et al.11 attributed the diffuse increased hepatic echogenicity mostly to fatty infiltration or hepatic granulomato - sis. However, hepatitis from infection or drugs can cause the observed hyperechoic and also hypoechoic hepatic parenchyma changes. In another study, biopsy-proven cases with similar hyperechoic hepatic lesions to those seen in this study were described as caused by either granuloma or haemangioma.7" 725 1190 W1997885526.pdf 5 6 separator 0.97624576 ¶ 1190 1192 W1997885526.pdf 5 7 text 0.9996265 "Renal disease may be caused by the HIV virus itself, secondary infections or the administered drugs. The statistically significant find - ing of more patients with renomegaly and associated increased cortical echogenicity may be ascribed to HIV nephropathy, which usually causes diffuse renal cortical echogenicity as well as renal enlargement.13 The pat - tern of increased renal cortical echogenicity seen in this study is similar to that described by some authors as AIDS nephropathy which is shown to occur primarily in black patients.7 Surprisingly, Hricak et al.5 found no correlation between renal sonographic appearance and the type of renal disease, while Schaffer et al.13 found no definite correlation between the degree of echogenicity and the severity of the renal disease." 1192 2004 W1997885526.pdf 5 8 separator 0.94199824 ¶ 2004 2006 W1997885526.pdf 5 9 text 0.9986579 "However, the abnormal renal sonographic findings in patients with AIDS suggest that even if a patient has no laboratory evidence of renal disease, a baseline renal sonogram could be useful for comparison if the patient ultimately presents with proteinuria or uraemia.13 Furthermore," 2006 2298 W1997885526.pdf 5 10 title 0.9876415 T able VI. Bowel activity v. CD4+ classification 2298 2347 W1997885526.pdf 5 11 separator 0.92838067 ¶ 2347 2349 W1997885526.pdf 5 12 table 0.99293494 "CD4+ classification Gastrointestinal peristalsis Total N (% within class) Hypoactive Normoactive Hyperactive Not significant 0 (0.0%) 34 (97.1%) 1 (2.9%) 35 (100%) Mild 2 (3.2%) 60 (95.2%) 1 (1.6%) 63 (100%) Advanced 2 (3.2%) 58 (92.1%) 3 (4.8%) 63 (100%) Severe 9 (6.5%) 124 (89.2%) 6 (4.3%) 139 (100%) Total 13 (4.3%) 276 (92.0%) 11 (3.7%) 300 (100%) Chi-square = 3.866; p = 0.680." 2349 2747 W1997885526.pdf 5 13 separator 0.9892178 ¶ 2747 2749 W1997885526.pdf 5 14 caption 0.995128 "Fig. 8. Abdominal ultrasound image showing an intra-abdominal abscess with echogenic debris within it." 2749 2855 W1997885526.pdf 5 15 separator 0.9770911 ¶ 2855 2857 W1997885526.pdf 5 16 caption 0.99388486 "Fig. 9. Abdominal ultrasound image showing an anterior abdominal wall abscess." 2857 2939 W1997885526.pdf 5 17 separator 0.9535413 ¶ 2939 2941 W1997885526.pdf 5 18 paratext 0.96340185 trans-abdominal.indd 39 6/8/09 2:01:09 PM 2941 2987 W1997885526.pdf 5 0 paratext 0.9787238 "International Journal for Multidisciplinary Research (IJFMR) ¶ E-ISSN: 2582 -2160 ● Website: www.ijfmr.com ● Email: editor@ijfmr.com" 0 152 W4367050518.pdf 4 1 separator 0.5336712 ¶ ¶ 154 160 W4367050518.pdf 4 2 paratext 0.9796688 IJFMR2302 199 Volume 5, Issue 2, March -April 2023 5 160 214 W4367050518.pdf 4 3 separator 0.93238544 ¶ ¶ 215 221 W4367050518.pdf 4 4 text 0.9986822 "the proportion of the distribution of age group who still use the heritage language; the heritage language ability. According to this system, the endangered language should meet the following three conditions: 1) 80% of the national population have shifted to use the dominant language and the number is increasing; 2) the heritage language is only used by middle -aged and senior people above 40 specifically; 3) the heritage language users only have the listening ability and have lost s peaking ability. These three complement with each other, and if these three conditions are met, it can be defined as the endangered language.3 Based on the above parameters till now, there exist 120 languages in PRC and more than 20 languages are in danger . It is estimated that more than 20% of languages will disappear within the next 20-50 years (S.X.Xu. 2001). Under such a socio -cultural scenario the Chinese Communist Party decided the protection of the endangered languages by adopting various academic pr ojects at the institutional and policies at the government level." 221 1323 W4367050518.pdf 4 5 separator 0.9967903 ¶ 1325 1327 W4367050518.pdf 4 6 title 0.96761346 Efforts at the Institutional Level: 1327 1363 W4367050518.pdf 4 7 separator 0.9710543 ¶ 1365 1367 W4367050518.pdf 4 8 text 0.999633 "Off let the Chinese government is running various projects and schemes for conserving the threatened languages. Through these projects and schemes, the government is trying to create awareness of the importance of languages. Since the early 90’s the awaren ess program has reached a new height. The awareness period has been divided into the following phases:" 1367 1736 W4367050518.pdf 4 9 separator 0.85969603 ¶ 1738 1740 W4367050518.pdf 4 10 text 0.887459 1. The period of enlightenment and exploration( 启蒙和探索期 ) 1740 1797 W4367050518.pdf 4 11 separator 0.73382473 ¶ 1798 1800 W4367050518.pdf 4 12 text 0.66291845 2. The period of prosperity and transition ( 繁荣和转向期 ) 1800 1855 W4367050518.pdf 4 13 separator 0.99666405 ¶ 1856 1858 W4367050518.pdf 4 14 title 0.94412696 1. The period of enlightenment and exploration( 启蒙和探索期 ): 1858 1916 W4367050518.pdf 4 15 separator 0.9805402 ¶ 1918 1920 W4367050518.pdf 4 16 text 0.9976385 "The very term “endangered language” itself is a new phenomenon. Until the 1990’s the word “endangered” was usually associated with flora, fauna, birds and species. However, in as early as the mid to late 1980s, linguists from the Institute of Ethnic Stu dies of the Chinese Academy of Social Sciences ( 中国社会科学院民族研究所 ) during some investigations at southwest China came across some languages which are not at all comprehendible to them. Records also revealed that those languages were never been recognised by any of the National languages Census so far held. Among them , few languages were only spoken by the elderly, middle -aged people of a particular speech community. Children no longer use them and thus will disappear completely after the death of the elderly spe akers in the next 20 to 30 years. Some of these languages in the 1980’s itself had no fluent speakers. From then onwards the phenomenon of language endangerment was much discussed in the academic circle. In the year 1992, at the 15th International Congr ess of Linguists ( 十五届国际语言学家代表大会 Shíwǔjièguójìyǔyánxuéjiādàibiǎodàhuì ) the Chinese linguists for the first time formally discussed the concepts of endangered languages. The discussions of the meeting w ere published in a magazine titled as ""Mínzúyǔyán "" ( 民族语言) and thus the very concept “endangered language” became a new area of study in Chinese linguistics. With further field investigations in course of time , the subject gained much popularity. In the year 1996, Hong Kong University of Science and Technolo gy and the Institute of Ethnology and Anthropology of the Chinese Academy of Social Sciences collaborated to conduct in - depth research on the study of ""Endangered Languages of Southern China"", which was the first domestic project to name as endangered la nguage. In 1998, the Ministry of Education approved the fully -funded Ph.D. program project under the title “Survey and Research on Endangered Languages in Southwest China”. This is the first -ever endangered language Ph.D. program project supported by the Chinese " 1920 4046 W4367050518.pdf 4 17 separator 0.8330864 "¶ 3" 4046 4111 W4367050518.pdf 4 18 title 0.98168236 The Protection of Endangered Languages in Mainland China 4111 4168 W4367050518.pdf 4 19 paratext 0.6769048 Chun Zhang 4168 4179 W4367050518.pdf 4 0 bibliography 0.99798936 "45. Schirmer M, Ijaz UZ, D’Amore R, Hall N, Sloan WT, Quince C. Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform. Nucleic Acids Research. 2015;43(6):e37–e37. doi:10.1093/nar/gku1341." 0 236 W4394603965.pdf 35 1 separator 0.97834456 ¶ 236 238 W4394603965.pdf 35 2 bibliography 0.9978446 "46. Metzker ML. Sequencing technologies—the next generation. Nature Reviews Genetics. 2010;11(1):31–46. doi:10.1038/nrg2626." 238 365 W4394603965.pdf 35 3 separator 0.9658124 ¶ 365 367 W4394603965.pdf 35 4 bibliography 0.9975554 "47. F L ̈ ochel H, Heider D. Comparative analyses of error handling strategies for next-generation sequencing in precision medicine. Sci Rep. 2020;10(1):5750. doi:10.1038/s41598-020-62675-8." 367 561 W4394603965.pdf 35 5 separator 0.97718334 ¶ 561 563 W4394603965.pdf 35 6 bibliography 0.9975132 "48. Bonidia RP, Domingues DS, Sanches DS, de Carvalho ACPLF. MathFeature: Feature Extraction Package for DNA, RNA and Protein Sequences Based on Mathematical Descriptors. Briefings in Bioinformatics. 2022;23(1):bbab434. doi:10.1093/bib/bbab434." 563 814 W4394603965.pdf 35 7 separator 0.9638336 ¶ 814 816 W4394603965.pdf 35 8 bibliography 0.99778175 "49. Bonidia RP, Sampaio LDH, Domingues DS, Paschoal AR, Lopes FM, de Carvalho ACPLF, et al. Feature Extraction Approaches for Biological Sequences: A Comparative Study of Mathematical Features. Briefings in Bioinformatics. 2021;22(5):bbab011. doi:10.1093/bib/bbab011." 816 1090 W4394603965.pdf 35 9 separator 0.97071815 ¶ 1090 1092 W4394603965.pdf 35 10 bibliography 0.9979818 "50. Fickett JW. Recognition of Protein Coding Regions in DNA Sequences. Nucleic Acids Research. 1982;10(17):5303–5318. doi:10.1093/nar/10.17.5303." 1092 1241 W4394603965.pdf 35 11 separator 0.96519506 ¶ 1241 1243 W4394603965.pdf 35 12 bibliography 0.99803257 "51.Wang L, Park HJ, Dasari S, Wang S, Kocher JP, Li W. CPAT: Coding-Potential Assessment Tool Using an Alignment-Free Logistic Regression Model. Nucleic Acids Research. 2013;41(6):e74. doi:10.1093/nar/gkt006." 1243 1456 W4394603965.pdf 35 13 separator 0.968374 ¶ 1456 1458 W4394603965.pdf 35 14 bibliography 0.997513 "52. Holden T, Subramaniam R, Sullivan R, Cheung E, Schneider C, Jr GT, et al.; International Society for Optics; Photonics. ATCG nucleotide fluctuation of Deinococcus radiodurans radiation genes. 2007;6694:669417. doi:10.1117/12.732283." 1458 1701 W4394603965.pdf 35 15 separator 0.97608757 ¶ 1701 1703 W4394603965.pdf 35 16 bibliography 0.9975944 "53. Marsella L, Sirocco F, Trovato A, Seno F, Tosatto SCE. REPETITA: detection and discrimination of the periodicity of protein solenoid repeats by discrete Fourier transform. Bioinformatics. 2009;25(12):i289–i295. doi:10.1093/bioinformatics/btp232." 1703 1959 W4394603965.pdf 35 17 separator 0.96783036 ¶ 1959 1961 W4394603965.pdf 35 18 bibliography 0.99775326 "54. Anastassiou D. Genomic signal processing. IEEE Signal Processing Magazine. 2001;18(4):8–20. doi:10.1109/79.939833." 1961 2082 W4394603965.pdf 35 19 separator 0.9619675 ¶ 2082 2084 W4394603965.pdf 35 20 bibliography 0.9976305 "55. Pedregosa F, Varoquaux G, Gramfort A, Michel V, Thirion B, Grisel O, et al. Scikit-Learn: Machine Learning in Python. J Mach Learn Res. 2011;12(null):2825–2830. doi:10.5555/1953048.2078195." 2084 2282 W4394603965.pdf 35 21 separator 0.96186703 ¶ 2282 2284 W4394603965.pdf 35 22 bibliography 0.9977946 "56. Chawla NV, Bowyer KW, Hall LO, Kegelmeyer WP. SMOTE: Synthetic Minority Over-sampling Technique. Journal of Artificial Intelligence Research. 2002;16:321–357. doi:10.1613/jair.953." 2284 2473 W4394603965.pdf 35 23 separator 0.96553254 ¶ 2473 2475 W4394603965.pdf 35 24 bibliography 0.9978889 "57. Lemaˆ ıtre G, Nogueira F, Aridas CK. Imbalanced-Learn: A Python Toolbox to Tackle the Curse of Imbalanced Datasets in Machine Learning. J Mach Learn Res. 2017;18(1):559–563. doi:10.5555/3122009.3122026." 2475 2686 W4394603965.pdf 35 25 separator 0.97386146 ¶ 2686 2688 W4394603965.pdf 35 26 bibliography 0.9977593 "58. Akiba T, Sano S, Yanase T, Ohta T, Koyama M. Optuna: A Next-Generation Hyperparameter Optimization Framework. 2019; p. 2623–2631. doi:10.1145/3292500.3330701." 2688 2855 W4394603965.pdf 35 27 separator 0.9494556 ¶ 2855 2857 W4394603965.pdf 35 28 paratext 0.9446143 April 5, 2024 36/37. CC-BY 4.0 International license available under awas not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint (which this version posted April 9, 2024. ; https://doi.org/10.1101/2024.04.05.588226doi: bioRxiv preprint 2857 3213 W4394603965.pdf 35 0 paratext 0.95474523 "BCP Social Sciences & Humanities ADCS 2022 Volume 15 (2022) ¶ 231" 0 72 W4280551970.pdf 3 1 title 0.99208164 3.3 Building 3D Model Building 72 103 W4280551970.pdf 3 2 separator 0.994665 ¶ 104 106 W4280551970.pdf 3 3 text 0.9956683 "According to the floor plan of t he building parameterized vecto r type, it can be automatically and quickly generated in batches with the building he ight informati on (Figure 4 refers to the Completely Customizable Graphical User Interface). The specific implementa tion steps are as follows: (1) Import the building vector layer to the scene through ArcGIS Engine. ( 2) Query the floor information corresponding to each polygon in the building vector layer thro ugh Osg Earth, and generate the ""white model"" of the building model by automatically ""pulling up"". (3) Map the roof and wall textures, and set the positional relationship between the building model and the 3D terrain surface, such as whether it is attached to the ground. ( 4) Build a building group node a nd add it to the OSG scene terrain root node." 106 950 W4280551970.pdf 3 4 separator 0.9908099 ¶ ¶ 952 958 W4280551970.pdf 3 5 caption 0.9914944 Fig 4. Batch automatic generation of 3D models for buildings 958 1019 W4280551970.pdf 3 6 separator 0.9375435 ¶ ¶ 1020 1026 W4280551970.pdf 3 7 text 0.9985406 "This method can generate buildings in modern gardens in batches , and can control the texture maps of buildings through XML files, without the need for positionin g and texture maps for specific buildings." 1026 1239 W4280551970.pdf 3 8 separator 0.9968176 ¶ 1240 1242 W4280551970.pdf 3 9 title 0.9907096 4. Virtual Reality Module Integration 1242 1280 W4280551970.pdf 3 10 separator 0.99451447 ¶ ¶ 1281 1287 W4280551970.pdf 3 11 caption 0.9920094 Fig 5. Flow chart of virtual realit y scene rendering technology 1287 1352 W4280551970.pdf 3 12 separator 0.9899602 ¶ 1353 1355 W4280551970.pdf 3 13 text 0.99914205 "The virtual display on the host side can be rendered and displa yed in real time through OSG along with the data input and processing [8]. On the virtual reality helmet display device side, the display devices are two high-definition monitors that are close to the human eye. The 3D scene is rendered twice, and the matrix offset of the helmet based on the scene s pace position is calculated. Through a series of space transformation and texture rendering, the garde n landscape display on the virtual reality side is finally realized. For garden vegetation landsca pes with many elements and a large amount of data, the module integ rates LOD methods, scene occlus ion, Billboard, and field clipping methods to reduce program rendering consumption as much as poss ible. The domain range is small, and the above method can better ensure the real-time rendering of the scene in the virtual reality display. In addition, by integra ting the multi-sampling anti-al iasing (MSAA) method, the scene model " 1356 2386 W4280551970.pdf 3 14 separator 0.7080049 ¶ 2386 2387 W4280551970.pdf 3 0 paratext 0.93270904 ¶ www.aging -us.com 10406 AGING 1 34 W3026495924.pdf 8 1 title 0.7604727 "essential hormone for women and that exogenous testosterone enhances cognitive performance and musculoskeletal health in postmenopausal women [" 35 186 W3026495924.pdf 8 2 paratext 0.5167012 66] 186 189 W3026495924.pdf 8 3 title 0.8115871 ", the effects of TP supplementation on mitochondrial complex V function in f emale animals should be examined in a future study." 189 326 W3026495924.pdf 8 4 separator 0.9800022 ¶ ¶ 328 334 W3026495924.pdf 8 5 text 0.9997009 "In summary, testosterone supplementation overcame the deficits in mitochondrial complex V in the SN in aged male rats. During aging, testosterone supplementation increased ATP levels and enhanced mitocho ndrial complex V activity in the SN by upregulating ATP6 and ATP8. Thus, mitochondrial ATP6 and ATP8, as potential testosterone targets, may maintain nigrostriatal dopaminergic function in aged males to some extent." 334 777 W3026495924.pdf 8 6 separator 0.98985696 ¶ ¶ 779 785 W3026495924.pdf 8 7 title 0.991509 MATERIALS AND METHOD S 785 808 W3026495924.pdf 8 8 separator 0.9498479 ¶ ¶ 809 815 W3026495924.pdf 8 9 title 0.92927897 Animals 815 823 W3026495924.pdf 8 10 separator 0.84606177 ¶ ¶ 825 831 W3026495924.pdf 8 11 text 0.9995899 "Male Sp rague -Dawley rats supplied by the Experimental Animal Center of Hebei Medical University were housed at a controlled temperature (22 ± 2 °C) on a 12 -h light -dark cycle (lights on at 6:00 AM). Food and water were available ad libitum . The experimental proced ures were approved by the Committee of Ethics on Animal Experiments at Hebei Medical University." 831 1216 W3026495924.pdf 8 12 separator 0.9805469 ¶ ¶ 1218 1224 W3026495924.pdf 8 13 title 0.9845871 Experiment 1 1224 1237 W3026495924.pdf 8 14 separator 0.91554075 ¶ ¶ 1239 1245 W3026495924.pdf 8 15 text 0.99970603 "Forty -five rats were used to study the effects of testosterone supplementation on mitochondrial complex V function in aged male rats. The rats w ere randomly divided into the following three groups: the 6 -month - old group (6Mon, n=15), the 24 -month -old group (24Mon, n=15) and the 24 -month -old with TP supplementation group (24Mon -TP, n=15). For the 24Mon -TP group, the rats were subcutaneously injecte d with TP (1 mg/kg per day) for 12 weeks beginning at the age of 21 months. The body weights of the rats in the 24Mon and 24Mon -TP groups were documented every three weeks. The rats in the 6Mon and 24Mon groups were injected with sesame oil rather than TP. In this experiment, coordinated motor behavior was analyzed , as well as ATP levels and mitochondrial complex V activity in the SN. Then, SNP screening, real-time quantitative polymerase chain reaction (qPCR) and Western blot analyses were performed." 1245 2218 W3026495924.pdf 8 16 separator 0.98463583 ¶ ¶ 2220 2226 W3026495924.pdf 8 17 title 0.9886569 Experiment 2 2226 2239 W3026495924.pdf 8 18 separator 0.9625272 ¶ ¶ 2241 2247 W3026495924.pdf 8 19 text 0.9997376 "Thirty -six adult male rats were used to investigate the effects of testosterone deficiency and testosterone replacement on mitochondrial complex V function. The rats were randomly divided into the following three groups: the sham -operated gro up (n=12), the gonadectomized group (GDX, n=12) and the GDX with TP administration group (GDX -TP, n=12). The gonadectomy and the sham operation were performed as described previously [3]. For the GDX -TP group , the castrated rats were subcutaneously injecte d with TP for four weeks (1 mg/kg per day ) [14]. The rats in the sham and GDX groups were injected with sesame oil rather than TP. In this experiment, ATP levels and mitochondrial complex V activity in the SN were analyzed. Then, qPCR and Western blot anal yses were performed to detect alterations in the mitochondrial complex V subunits in GDX or GDX -TP rats." 2247 3162 W3026495924.pdf 8 20 separator 0.99175906 ¶ ¶ 3164 3170 W3026495924.pdf 8 21 title 0.99272615 Cylinder test 3170 3184 W3026495924.pdf 8 22 separator 0.9777382 ¶ ¶ 3186 3192 W3026495924.pdf 8 23 text 0.99667245 "The apparatus for the cylinder test was a transparent plexiglass cylinder with a diameter of 20 cm and a height of 30 cm . The rats were handled for about 10 min per day for two weeks, and were naive to the apparatus. At the time of the test, the rats were individually placed in the cylinder and were recorded with a digital video camera for 5 min [29]. The number of times th e rats contacted the wall with both forelimbs during rearing was documented [2]." 3192 3675 W3026495924.pdf 8 24 separator 0.992169 ¶ ¶ 3676 3682 W3026495924.pdf 8 25 title 0.99380857 Tapered beam walking test 3682 3708 W3026495924.pdf 8 26 separator 0.97831154 ¶ ¶ 3710 3716 W3026495924.pdf 8 27 text 0.99573153 "The tapered beam walking test procedure and score calculation method used in this study were described in detail by Strome et al. [30] and Wang et al. [2], respectively . In brief, 2 cm below a 165 -cm-long beam, there was a 2.5 -cm-wide ledge on each side, which provided a platform on which the rats could step. The beam was narrower at one end than at the other (6.5 cm wide at the wide end, 1.5 cm at t he narrow end). The beam was divided into wide, medium and narrow segments for scoring. The day before the test, the rats were allowed to walk on the tapered beam for training. The following day, each rat was tested five times, and the tests were recorded with a digital video camera." 3716 4444 W3026495924.pdf 8 28 separator 0.9085913 ¶ 4445 4447 W3026495924.pdf 8 29 text 0.9995875 "Taking a step with one or two toes of the hindlimb on the main surface of the beam with the other four or three toes overhanging the ledge was scored as a half - foot fault, while stepping with the entire foot on the ledge rather than on the main surface of the beam was scored as a full -foot fault. We used the mean value of the scores for the five tapered beam walking tests from the narrow section of the beam for statistical analysis." 4447 4908 W3026495924.pdf 8 30 separator 0.99171865 ¶ ¶ 4910 4916 W3026495924.pdf 8 31 title 0.99216866 Sample preparation 4916 4935 W3026495924.pdf 8 32 separator 0.9807491 ¶ ¶ 4937 4943 W3026495924.pdf 8 33 text 0.9996751 "The rats were sacrificed by decapitation and their brains were removed quickly. The tissue block containing the SN (between 3.00 mm and 4.08 mm rostral to the interaural axis ) [67] was dissected with an ophthalmic scalpel on an ice -cold plate under a stereomicroscope. It" 4943 5233 W3026495924.pdf 8 0 paratext 0.98891765 Geriatrics 2022 ,7, 82 7 of 16 0 30 W4291464210.pdf 6 1 separator 0.994395 ¶ 30 32 W4291464210.pdf 6 2 text 0.9899683 "“I like to do some shopping or have a coffee in the tea-room of the shopping centre not far from my home, five minutes’ walk away .” (Participant 11)" 32 183 W4291464210.pdf 6 3 separator 0.8109172 ¶ 183 185 W4291464210.pdf 6 4 text 0.9969509 "“Every afternoon, I do a group activity: aquafit twice a week, Tai-chi once a week, osteopathic-fitness once a week or walks .” (Participant 15)" 185 330 W4291464210.pdf 6 5 separator 0.9773581 ¶ 330 332 W4291464210.pdf 6 6 text 0.9993555 "These participants also regularly shopped in grocery shops ( n= 7), usually two or three times a week (both n= 3); collected medicine from a pharmacy ( n= 7), about once a week ( n= 3); and bought bread at a bakery ( n= 7), usually every day or three times per week (both n= 3). —see Figure 1." 332 632 W4291464210.pdf 6 7 separator 0.9717192 ¶ 632 634 W4291464210.pdf 6 8 text 0.99387115 "“Every morning, on my way back from the village caf é, I stop to buy bread at my village bakery, and I talk to the sales ladies I know well. ” (Participant 6)" 634 795 W4291464210.pdf 6 9 separator 0.9547975 ¶ 795 797 W4291464210.pdf 6 10 text 0.97914016 “We usually go to the little cooperative shop in our neighbourhood .” (Participant 14) 797 884 W4291464210.pdf 6 11 separator 0.98827314 ¶ 884 886 W4291464210.pdf 6 12 text 0.99905187 "Finally, the older adult participants without self-reported cognitive impairments often frequented places of worship ( n= 4), about once a week ( n= 3); restaurants ( n= 4), about once a week ( n= 3); a butcher’s shop ( n= 4), twice a week ( n= 3); and the post office ( n= 4), once a week ( n= 2) or twice a month ( n= 2). —see Figure 1." 886 1230 W4291464210.pdf 6 13 separator 0.9806669 ¶ 1230 1232 W4291464210.pdf 6 14 text 0.9821541 “I regularly see the butcher I go to, about twice a week .” (Participant 11) 1232 1309 W4291464210.pdf 6 15 separator 0.8538856 ¶ 1309 1311 W4291464210.pdf 6 16 text 0.9936853 "“I often go for lunch at my usual restaurant, about twice a week, and to the post office counter every two weeks to pick up orders .” (Participant 12)" 1311 1463 W4291464210.pdf 6 17 separator 0.9387578 ¶ 1463 1465 W4291464210.pdf 6 18 text 0.9968787 "“We go to church every Sunday and talk with the other participants and the priest, and we have become familiar with each other. We are like a community; we all know one another .” (Participant 14)" 1465 1666 W4291464210.pdf 6 19 separator 0.9854753 ¶ 1666 1668 W4291464210.pdf 6 20 text 0.9993346 "The locations most frequented by the panel of five older adults with a probable or diagnosed slight cognitive impairment or mild-to-moderate dementia were: caf és or tearooms ( n= 3), mostly three times per week ( n= 2), but also every day ( n= 1); large supermarkets in town ( n= 2), twice per week ( n= 2); leisure centres such as a tennis club or a swimming pool, twice per week ( n= 1) and every day ( n= 1), respectively; and day centres ( n= 2), four times per week ( n= 1) and twice per week ( n= 1). —see Figure 2." 1668 2200 W4291464210.pdf 6 21 separator 0.9874948 ¶ 2200 2202 W4291464210.pdf 6 22 paratext 0.9806309 Geriatrics 2022 , 7, x FOR PEER REVIEW 8 of 17 2202 2249 W4291464210.pdf 6 23 separator 0.95621693 ¶ ¶ 2250 2256 W4291464210.pdf 6 24 text 0.9854612 "“I usually go for a walk three times a week wi th a friend, and we go for coffee in a tearoom near my house. I also go shopping with my daughter, once a week, in a supermarket.” " 2256 2441 W4291464210.pdf 6 25 separator 0.57007366 ¶ 2441 2442 W4291464210.pdf 6 26 text 0.98892015 (Participant 21—early-stage Alzheimer’s disease) 2442 2491 W4291464210.pdf 6 27 separator 0.99020475 ¶ ¶ 2492 2498 W4291464210.pdf 6 28 caption 0.9948027 "Figure 2. Types of locations frequented by study participants with a probable or diagnosed slight cognitive impairment or mild-to-moderate dementia." 2498 2650 W4291464210.pdf 6 29 separator 0.995279 ¶ 2651 2653 W4291464210.pdf 6 30 text 0.9995239 "In general, older adults without self-reported cognitive impairments, like older adults with cognitive impairments, were very well surrounded by a network of family, neighbours and friends. Cross-referencing the places frequented by the two panels of par- ticipants revealed, that the first three most frequented places were the same. The only differences between the two panels of participants were that older adults without self- reported cognitive impairments were more physically active, busier (e.g., taking care of grandchildren) and did more activities (e.g., walking, shopping, etc.)." 2653 3259 W4291464210.pdf 6 31 separator 0.9967165 ¶ 3260 3262 W4291464210.pdf 6 32 title 0.99127775 3.2.2. Theme 2: Social Networks 3262 3294 W4291464210.pdf 6 33 separator 0.9968451 ¶ 3295 3297 W4291464210.pdf 6 34 text 0.9994235 "Older adult participants without self-repor ted cognitive impairments were able to identify the non-healthcare workers with whom they were regularly in contact in their day-to-day life: checkout workers at supermarkets in town (n = 12); café and tearoom staff and managers (n = 8); leisure centre staff (s ports coaches, swimming instructors, dance teachers) (n = 8); grocery shop checkout workers (n = 7); pharmacists and pharmacy assis- tants (n = 7); bakery sales staff (n = 7); priests and pastors (n = 4); restaurant staff and managers (n = 4); butchers (n = 4); and post office counter workers (n = 4) (Figure 3)." 3297 3928 W4291464210.pdf 6 35 separator 0.99511606 ¶ 3929 3931 W4291464210.pdf 6 36 caption 0.994741 "Figure 2. Types of locations frequented by study participants with a probable or diagnosed slight cognitive impairment or mild-to-moderate dementia." 3931 4082 W4291464210.pdf 6 37 separator 0.99430907 ¶ 4082 4084 W4291464210.pdf 6 38 text 0.98899764 "“I get up every day at 5:15 and have breakfast. At 6 o’clock, a friend picks me up in her car to meet our group of friends at the pool. We swim for 45 minutes, and then we always take time for a coffee in a tearoom right next to the pool .” (Participant 19—moderate vascular dementia)" 4084 4375 W4291464210.pdf 6 39 separator 0.92161715 ¶ 4375 4377 W4291464210.pdf 6 40 text 0.9789172 "“At the end of the morning, about four times a week, I attend an activity organised by the social workers in the community hall, such as gymnastics .” (Participant 20—moderate Alzheimer’s disease)" 4377 4578 W4291464210.pdf 6 0 paratext 0.9897472 Diversity 2023 ,15, 899 12 of 22 0 32 W4385421112.pdf 11 1 separator 0.9892821 ¶ 32 34 W4385421112.pdf 11 2 text 0.9852787 "thickness of ischiopubic bar. Iliac processes massive and curving inwards, with broad, quadrangular tip. Each iliac region with two foramina." 34 178 W4385421112.pdf 11 3 separator 0.81134444 ¶ 178 180 W4385421112.pdf 11 4 text 0.9945189 "Scapulocoracoid . Scapulocoracoid elongated rectangular in lateral view, with very asymmetrical anterior position of the mesocondyle. Overall shape and number, shape and arrangement of postdorsal and postventral foramina variable, but scapulocoracoid always with a solid horizontal anterior bridge separating the anterior fenestra into a smaller anterior dorsal and an anterior ventral fenestra. Overall shape moderately short to elongated rectangular, with rounded to sharply marked rear corner and nearly straight to deeply concave posterior margin sloping to the metacondyle. Anterior dorsal and ventral fenestrae large, postdorsal fenestrae large or a combination of a large anterior fenestra and several small foramina, postventral fenestrae mostly small and arranged in a chain along the ridge between meso- and metacondyle. Pre-mesocondyle length 25.6–38.0% of maximum length and 35.7–58.7% of post-mesocondyle length. Maximum length 1.3–1.6 times maximum height at scapular process. Height at rear corner 83.3–85.3% of maximum height. Combined height of both anterior fenestrae 37.4–43.3% of maximum height at scapular process and 26.8–28.8% of the element’s maximum length." 180 1389 W4385421112.pdf 11 5 separator 0.9953213 ¶ 1389 1391 W4385421112.pdf 11 6 title 0.84688646 Skeletal meristics 1391 1410 W4385421112.pdf 11 7 separator 0.76137286 1410 1411 W4385421112.pdf 11 8 table 0.95174706 ". Trunk vertebrae (Vtr): 30–37; predorsal tail vertebrae (Vprd): 66–80; total predorsal vertebrae: 97–113; terminal tail vertebrae (Vterm, approximately): 23–40; total vertebrae (Vtotal, approximately): 120–151; pectoral radials, left: 70–89, right: 70–90; pelvic radials, left: 4+16–5+20, right: 4+17–5+19." 1411 1724 W4385421112.pdf 11 9 separator 0.9962651 ¶ 1724 1726 W4385421112.pdf 11 10 title 0.99249506 3.2.3. Egg Case Morphology 1726 1753 W4385421112.pdf 11 11 separator 0.9954004 ¶ 1753 1755 W4385421112.pdf 11 12 text 0.9972206 "The description of the egg case morphology is based on the lectotype (IRSNB 25 [orig. 3005]) and paralectotypes (IRSNB 26 [orig. 3006] and IRSNB 27 [orig. 3007]), as well as two egg cases catalogued under ZMH 9014). Figure 6 shows the lectotype and paralectotype egg cases in dorsal and ventral views, Table 1 provides morphometrics of all five egg cases." 1755 2116 W4385421112.pdf 11 13 separator 0.99058235 ¶ 2116 2118 W4385421112.pdf 11 14 paratext 0.9856051 Diversity 2023 , 15, x FOR PEER REVIEW 14 of 24 2118 2166 W4385421112.pdf 11 15 separator 0.9284444 "¶ ¶" 2167 2178 W4385421112.pdf 11 16 caption 0.9884938 "Figure 6. Bathyraja arctowskii , three empty egg cases, IRSNB, Brussels, Belgium. ( 1a,b) lectotype IRSNB 25; ( 2a,b) paralectotype IRSNB 26; ( 3a,b) paralectotype IRSNB 27. ( 1a–3a) dorsal views; ( 1b– 3b) ventral views. Scale bar: 40 mm." 2178 2423 W4385421112.pdf 11 17 separator 0.987512 ¶ 2424 2426 W4385421112.pdf 11 18 table 0.5532567 Table 1. Bath 2426 2440 W4385421112.pdf 11 19 title 0.51342416 yraja arctowskii , 2440 2459 W4385421112.pdf 11 20 table 0.81974024 "morphometrics of the lectotype IRSNB 25, the two paralectotypes IRSNB 26 and IRSNB 27, as well as two egg cases catalogued under ZMH 9014; all values are given in mm." 2459 2632 W4385421112.pdf 11 21 separator 0.8066464 ¶ 2633 2635 W4385421112.pdf 11 22 table 0.99228185 "ZMH 9014 ZMH 9014 IRSNB 25 IRSNB 26 IRSNB 27 * empty egg case egg case with embryo empty egg case empty egg case empty egg case ECTL_1, egg case total length incl. length of bent horns (along curve) 141.5 146.4 >126.4 (d) >118.1 (d) >112.5 (d) ECTL_2, egg case total length incl. horizontal length of bent horns 121.8 120.2 >105.9 >96.5 >99.5 ECL, egg case length; measured longitudinally between the anterior and posterior apron borders 77.6 76.1 67.5 64.3 62.6 AAL, anterior apron length 5.1 5.1 4.5 3.7 7.0 PAL, posterior apron length 12.6 12.9 15.6 (b) 10 .5 (b) 15.1 * ABW, anterior border width; distance between the bases of the anterior horns 20.1 20.0 22.9 19.4 23.0 PBW, posterior border width; distance between the bases of the posterior horns 21.0 21.1 23.8 20.5 24.8 MAW, maximum case width; transverse width of the case in its lateral plane at its widest part 42.3 40.7 42.1 37.4 32.1 *" 2636 3602 W4385421112.pdf 11 23 separator 0.9896453 ¶ 3603 3605 W4385421112.pdf 11 24 caption 0.99143136 "Figure 6. Bathyraja arctowskii , three empty egg cases, IRSNB, Brussels, Belgium. ( 1a,b) lectotype IRSNB 25; ( 2a,b) paralectotype IRSNB 26; ( 3a,b) paralectotype IRSNB 27. ( 1a–3a) dorsal views; (1b–3b) ventral views. Scale bar: 40 mm." 3605 3847 W4385421112.pdf 11 0 paratext 0.9840919 ISSN 2522 -9842 Journal of Scientific Papers “Social Development and Security ”, Vol. 1 1, No. 4, – 2021 0 106 W4206804627.pdf 12 1 separator 0.96699905 ¶ ¶ 107 113 W4206804627.pdf 12 2 text 0.9865472 "управления, обеспечив ая тем самым непрерывность процесса управлен ия чрезвычайной ситуацией террористического характера в интересах ее недопущения и предотвращения. После чего определить пути повышения эффективности систем физической защиты охраняемых объектов критической инфра структуры государства. Показано, что одним и з перспективных направлений повышения эффективности процесса управления чрезвычайной ситуацией террористического характера на охраняемых объектах критической инфраструктуры государства является совершенствование систем физической защиты путем разработки но вых устройств и систем акустического контроля помещений и территорий объекта и снятия языковой информации с использованием параболических, трубчатых и градиентных микрофонов и плоских акустических решеток, которы е обеспечивают прием акустических сигналов н а удалении от нескольких десятков до нескольких сотен метров и обеспечивают полную информацию о действиях и намерениях людей, регистрируемых в видео системах." 114 1149 W4206804627.pdf 12 3 separator 0.97839296 ¶ 1151 1153 W4206804627.pdf 12 4 paratext 0.45757708 "Ключевые слова: чрезвычайная ситуация, террористический акт, система ф изической защиты, акустичес кий контроль, направленный микрофон ." 1153 1294 W4206804627.pdf 12 5 separator 0.9904012 ¶ ¶ 1295 1301 W4206804627.pdf 12 6 title 0.9186316 "Ways to increase the effectiveness of physical protection systems of critical infrastructure of the state, protected" 1301 1421 W4206804627.pdf 12 7 separator 0.9884028 ¶ ¶ 1423 1429 W4206804627.pdf 12 8 contact 0.9641852 "Olena Azarenko * 1 А; Yulia Honcharenko 2 B; Mykhailo Divizinyuk 3 C; Volodymyr Mirnenko 4 D; Valeri y Strilets 5 A" 1429 1550 W4206804627.pdf 12 9 separator 0.93632144 ¶ 1551 1553 W4206804627.pdf 12 10 contact 0.99635255 * Corresponding author : 1 Dr, Professor, Deputy Head, e-mail: е-mail : azarenko _ev@ukr.net, ORCID : 0000 -0003 -2927 -5545 1553 1679 W4206804627.pdf 12 11 separator 0.75527185 ¶ 1681 1683 W4206804627.pdf 12 12 contact 0.9957912 2 Ph.D., Associate Professor, Professor of Department , e-mail: vup@e -u.in.ua , ORCID : 0000 -0003 -2045 -0263 1683 1796 W4206804627.pdf 12 13 separator 0.81617576 ¶ 1798 1800 W4206804627.pdf 12 14 contact 0.9833293 "3 Dr, Professor, H ead of Department, e -mail: divizinyuk@ukr.net, ORCID: 0000 -0002 -5657 -2302 4 Dr, Professor, Director of the Department, e -mail: mirnenkovi@gmail.com, ORCID: 0000 -0002 -7484 -1035 5 Head, e-mail: v.strelec.brand@gmail.com , ORCID : 0000 -0003 -1913 -7878" 1800 2086 W4206804627.pdf 12 15 separator 0.98111457 ¶ 2088 2090 W4206804627.pdf 12 16 contact 0.9901897 "А Research laboratory -experimental center “BRAND TRADE ” B European University , Kyiv, Ukraine C Institute of Environmental Geochemistry of the NAS of Ukraine , Kyiv, Ukraine D Department of Military Education and Science of the Ministry of Defense of Ukraine , Kyiv, U kraine" 2090 2380 W4206804627.pdf 12 17 separator 0.9886233 ¶ ¶ 2382 2388 W4206804627.pdf 12 18 title 0.9299721 Abstract 2388 2397 W4206804627.pdf 12 19 separator 0.9958447 ¶ 2399 2401 W4206804627.pdf 12 20 text 0.99838823 "The article is devoted to the definition of new ways to increase the effectiveness of physical protection systems of critical infrastructure, which are the main technical means of preventing terrorist a cts against these objects. The charac teristic of premises protection systems and control objects adjoining territories of critical infrastructure is described. It is shown that the functional purpose of the physical protection system includes devices and ala rm systems for detection, collectio n and processing of information, alarm, access control and management, optoelectronic surveillance, operational communication and notification, power supply and lighting, physical protection systems nuclear materials duri ng transportation." 2401 3164 W4206804627.pdf 12 21 separator 0.9632318 ¶ 3166 3168 W4206804627.pdf 12 22 text 0.43455765 "Keywords: emerge ncy, terrorist act, physical prote ction system, acoustic control, directional microphone ." 3168 3281 W4206804627.pdf 12 23 separator 0.9954531 ¶ 3282 3284 W4206804627.pdf 12 24 title 0.7783783 References 3284 3295 W4206804627.pdf 12 25 separator 0.99235064 ¶ 3308 3310 W4206804627.pdf 12 26 bibliography 0.99736756 "1. Azarenko E .V., Goncharenko Yu. Yu., Divizinyuk М. М., Ozhiganova M.I. Protection of critical infrastructure of the state from terrorist impa ct. Kyiv: IGNS NASU, 2018. 84 p. ISBN 97 8-617-7187 -25-6." 3310 3529 W4206804627.pdf 12 27 separator 0.8223959 ¶ 3530 3532 W4206804627.pdf 12 28 bibliography 0.9947133 "2. Azarenko , E., Honcharenko , Y., Divizinyuk , M., Mirnenko , V., & Syrytsia , I. (2020). Structural -logical model of emergency situation management of terrorist character and its features caused by lat ent electromagnetic influence on the operational staff of the guarded facility of critical infrastructure. Journal of Scientific Papers «Social Development and Security », 10(1), 177 -187." 3532 3950 W4206804627.pdf 12 29 separator 0.9154755 ¶ 3951 3953 W4206804627.pdf 12 30 paratext 0.9747892 212 3953 3957 W4206804627.pdf 12 0 paratext 0.8867253 "Frequency effects and structural change – the Afrikaans preterite http://spilplus.journals.ac.za 159" 0 105 W2495654804.pdf 12 1 separator 0.96831477 ¶ 106 108 W2495654804.pdf 12 2 title 0.9884491 4.2.3 “Kon ” 108 122 W2495654804.pdf 12 3 separator 0.98979557 ¶ ¶ 123 129 W2495654804.pdf 12 4 text 0.9984023 "The modal auxiliary kan (“can”) conveys both participant -internal ability and participant - external possibility. The preterite kon (“could” ) places the ability or pos sibility in the past (10 ), except when a wish o r desire is being expressed (11) , or if it is used in combination with sou (12)." 129 440 W2495654804.pdf 12 5 separator 0.9501655 ¶ ¶ 441 447 W2495654804.pdf 12 6 text 0.73872626 "(10) Hy kon ook ure aaneen die ou Joodse geskrifte lees en met Josef daaroo r gesels. (corpus #4, Religiou s)" 447 560 W2495654804.pdf 12 7 separator 0.4592309 ¶ 561 563 W2495654804.pdf 12 8 text 0.9355283 [He could read old Jewish texts for hours on end and discuss it with Josef.] 563 640 W2495654804.pdf 12 9 separator 0.8646588 ¶ 642 644 W2495654804.pdf 12 10 table 0.3961962 (11) 644 649 W2495654804.pdf 12 11 text 0.7888788 Ek wens jy kon bietjie in my kop inklim en kyk wat gaan aan. 649 710 W2495654804.pdf 12 12 table 0.37876505 ( corp 710 717 W2495654804.pdf 12 13 text 0.3317446 us 717 719 W2495654804.pdf 12 14 table 0.3512099 #4 720 723 W2495654804.pdf 12 15 text 0.4039469 , 723 724 W2495654804.pdf 12 16 bibliography 0.4084127 Manuscript 724 736 W2495654804.pdf 12 17 table 0.3985542 ) 736 737 W2495654804.pdf 12 18 text 0.8552086 ¶ [I wish you could climb into my head for a bit and see what ’s going on.] 738 814 W2495654804.pdf 12 19 separator 0.8721237 ¶ 816 818 W2495654804.pdf 12 20 text 0.8010405 (12) En veral met John sou ek kon uitgaan – hy is immers verlief op jou! 818 891 W2495654804.pdf 12 21 table 0.38830665 ( 891 893 W2495654804.pdf 12 22 text 0.43779466 corpus #2, Fiction) 893 913 W2495654804.pdf 12 23 separator 0.4869315 ¶ 915 917 W2495654804.pdf 12 24 text 0.9356498 [And especially with John I could go out – he is after all in love with you! ] 917 997 W2495654804.pdf 12 25 separator 0.98457146 ¶ 998 1000 W2495654804.pdf 12 26 text 0.9982253 "If example (11) would be reformulated with kan , the difference in meaning becomes clear where kon indicates a wish for an unrealistic or impossible matter, while kan indicates a wish for a real possibility. The original association of temporal distance between kan and kon is extended here to epistemic distance." 1001 1326 W2495654804.pdf 12 27 separator 0.904252 ¶ 1328 1330 W2495654804.pdf 12 28 text 0.9939323 "De Villiers (1971: 29) claims that when kan is used with epistemic modality in the past tense in formal tex ts, it would sometimes not undergo preterite assimilation. However, in a sample of 400 uses of kan from each corpus, I did not find any examples of this occurring. This does not necessarily mean that the possibility does not exist, rather that it is just too rare to surface in my data . " 1331 1746 W2495654804.pdf 12 29 separator 0.7064657 ¶ ¶ 1746 1751 W2495654804.pdf 12 30 text 0.98787594 Details regarding frequencies of kon and kan are given in table 12. 1751 1821 W2495654804.pdf 12 31 separator 0.98390687 ¶ ¶ 1823 1829 W2495654804.pdf 12 32 table 0.98235595 "Table 12: Frequencies of kan and kon 1911–2010 1911 –1920 1941 –1950 1971 –1980 2001 –2010 kan 959 74,6% 1 053 75,7% 1 290 81,7% 1 357 80,5% kon 326 25,4% 344 24,6% 289 18,3% 329 19,5% Total 1 285 1 397 1 579 1 686" 1829 2079 W2495654804.pdf 12 33 separator 0.98000646 ¶ 2082 2084 W2495654804.pdf 12 34 text 0.99729353 "It seems that kon also shows no definite change – the total frequencies and the ratio with kan shows variability , but it is not statistically significant 6, and does not show a strong direction of change. However, t he increase of kan is significant7." 2085 2352 W2495654804.pdf 12 35 separator 0.96101695 ¶ ¶ 2353 2359 W2495654804.pdf 12 36 title 0.9903913 4.2.4 “Moes ” 2359 2374 W2495654804.pdf 12 37 separator 0.9923754 ¶ ¶ 2375 2381 W2495654804.pdf 12 38 text 0.98909664 "The modal auxiliary moet (“must ”) indicates both deontic and epistemic modality, with the preterite moes , which is used solely in the past tense. While moet merges with nie in the negative ¶" 2381 2580 W2495654804.pdf 12 39 separator 0.92158294 ¶ 2630 2632 W2495654804.pdf 12 40 text 0.9374944 "6 While the decrease from corpus #2 to #3 shows a low level of significance (with a log -likelihood result of 4 .49), the increase to corpus #4 cancels this out." 2632 2803 W2495654804.pdf 12 41 separator 0.9555867 ¶ 2805 2807 W2495654804.pdf 12 42 table 0.6364727 "7 Log-likelihood for all four corpora consecutively: 96. 23; corpus #1 to #2: 4.64 (low le vel of significance); corpus #2 to #3: 25.34; corpus #3 to #4: 1.48 (insignificant) ." 2807 2987 W2495654804.pdf 12 0 paratext 0.98502207 1167 Clinical and Translational Oncology (2022) 24:1157–1167 0 60 W4225550271.pdf 10 1 separator 0.9043956 ¶ 61 63 W4225550271.pdf 10 2 paratext 0.97689754 1 3 63 67 W4225550271.pdf 10 3 separator 0.9631008 ¶ 67 69 W4225550271.pdf 10 4 bibliography 0.944141 "cancer: long-term results of the EORTC 22921 randomised study. Lancet Oncol. 2014;15:184–90." 69 165 W4225550271.pdf 10 5 separator 0.96496254 ¶ 165 167 W4225550271.pdf 10 6 bibliography 0.9946183 "52. Rödel C, Graeven U, Fietkau R, et al. Oxaliplatin added to fluo- rouracil-based preoperative chemoradiotherapy and postopera- tive chemotherapy of locally advanced rectal cancer (the German CAO/ARO/AIO-04 study): final results of the multicentre, open- label, randomised, phase 3 trial. Lancet Oncol. 2015;16:979–89." 168 498 W4225550271.pdf 10 7 paratext 0.5699057 Publisher 498 507 W4225550271.pdf 10 8 title 0.4844319 's 507 509 W4225550271.pdf 10 9 paratext 0.5113543 Note 509 515 W4225550271.pdf 10 10 bibliography 0.47444358 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 515 636 W4225550271.pdf 10 0 text 0.9973701 "measured parameters (reduction of turbidity and water con - tent, increase of volume of filtrate) for all of the tested poly - mers. Therefore, increasing the dosage does not necessarily result in better chemical conditioning, which emphasizesthe importance of obtaining an optimum dosage, as alsodiscussed in studies by Tominaga (2010)." 0 343 W4246083262.pdf 22 1 separator 0.9972662 ¶ 343 345 W4246083262.pdf 22 2 title 0.99306107 3.2. Dewatering tests in geotextile bags 345 386 W4246083262.pdf 22 3 separator 0.9959309 ¶ 386 388 W4246083262.pdf 22 4 text 0.9995571 "The ASTM International published a standard method to determine the flow rate of water and suspendedsolids in a geosynthetic permeable bag containing high wa-ter content sludges (ASTM D 7701, 2011). This methodol-ogy describes two test methods. One test involves using ageotextile bag with a 114 cm inner circumference, a lengthof 165 cm and a volumetric test capacity of 150 to 190 L.The other test uses a geotextile bag with a 1.52 m circum-ference, a depth of 0.92 m, with a volumetric test capacityof 19 L." 388 901 W4246083262.pdf 22 5 separator 0.969721 ¶ 901 903 W4246083262.pdf 22 6 text 0.9991015 "The Geosynthetic Research Institute (GRI) has also proposed methodologies to analyze the behaviors of mate - rials in dewatering, such as GRI-GT14 (2004) and GRI- GT15 (2009). The first method is for field dewatering ofsolids in a hanging bag test (HBT), as shown in Fig. 7, withone of the faces open and a linear length between 0.3 and7.0 m." 903 1252 W4246083262.pdf 22 7 separator 0.96968734 ¶ 1252 1254 W4246083262.pdf 22 8 text 0.9989063 "The GRI-GT15 (2009) serves an identical purpose as the GRI-GT14 (2004); however, it uses geotextile bagswith approximate dimensions of 50 to 65 cm in length, 38to 65 cm in width and a volumetric capacity of 20 to 30 L.These bags contain an adapter flange to guide the sludgewith polymeric additives into the bags (Fig. 8). Another dif - ference between the methods is that the GRI-GT15 (2009) allows for the monitoring of the dewatering performanceover time by observing the dehydrated material column(cm) by test time (min)." 1254 1786 W4246083262.pdf 22 9 separator 0.9339575 ¶ 1786 1788 W4246083262.pdf 22 10 text 0.9980468 "Castro et al. (2009) conducted a comparative study of both methods described above. This study showed that theGRI-GT15 (2009) method produces results very close theactual application of dewatering in geotextile bags; thesludge remains confined within the geotextile bags, which allows for better dewatering and prevents rehydration of thedry sludge. There is also a low breakdown of chemical con - ditioning with the introduction of sludge within the geotex -" 1788 2254 W4246083262.pdf 22 11 separator 0.9690931 ¶ 2254 2256 W4246083262.pdf 22 12 paratext 0.9691704 256 Soils and Rocks, São Paulo, 36(3): 251-263, September-December, 2013.Guimarães & Urashima 2256 2350 W4246083262.pdf 22 13 separator 0.99597466 ¶ 2350 2352 W4246083262.pdf 22 14 caption 0.9960286 "Figure 6 - Cone tests with 15 mL polymer dosage at a concentra - tion of 0.004 g.L-1." 2352 2440 W4246083262.pdf 22 15 separator 0.98103845 ¶ 2440 2442 W4246083262.pdf 22 16 caption 0.995654 Figure 7 - Hanging bag test (Lawson, 2008). 2442 2486 W4246083262.pdf 22 17 separator 0.97331476 ¶ 2486 2488 W4246083262.pdf 22 18 caption 0.996445 Figure 8 - Tests in geotextile closed according to GRI-GT15 2488 2548 W4246083262.pdf 22 19 separator 0.51243424 2548 2549 W4246083262.pdf 22 20 caption 0.9430289 ¶ (Geosynthetic Research Institute, 2009). 2549 2591 W4246083262.pdf 22 0 paratext 0.9881587 Page 7/19 0 9 W4310474401.pdf 6 1 title 0.8888695 Ingredients Diets 9 26 W4310474401.pdf 6 2 separator 0.8719994 ¶ 26 28 W4310474401.pdf 6 3 table 0.99630016 "PC NC SHP TH SH Ca(H2PO3)2a 1.00 1.00 1.00 1.00 1.00 Microcrystalline cellulosea 2.00 2.00 2.00 2.00 2.00 Carboxymethyl cellulosea 1.00 1.00 1.00 1.00 1.00 Zeolite powdera 6.50 1.77 2.71 5.27 5.27 Crystalline lysinea 0.00 0.71 0.60 0.71 0.71 Crystalline methioninea 0.00 0.15 0.15 0.15 0.15" 28 331 W4310474401.pdf 6 4 separator 0.6283525 ¶ 331 333 W4310474401.pdf 6 5 table 0.9789669 "Proximate analysis (Mean values, % dry weight) Moisture 4.67 4.65 3.83 5.41 6.12 Crude protein 51.80 51.80 52.00 51.30 50.70 Crude lipid 13.17 12.09 12.31 13.03 13.23 Ash 16.00 9.70 11.00 9.70 9.50" 333 539 W4310474401.pdf 6 6 separator 0.98094547 ¶ 539 541 W4310474401.pdf 6 7 table 0.7095523 a 541 543 W4310474401.pdf 6 8 text 0.4729899 Supplied by 543 554 W4310474401.pdf 6 9 contact 0.60097563 Xinxin Tian’en Aquatic Feed Co., Ltd 554 591 W4310474401.pdf 6 10 text 0.48275962 ( 591 593 W4310474401.pdf 6 11 contact 0.5168289 Zhejiang 593 601 W4310474401.pdf 6 12 text 0.51856804 , China). 601 610 W4310474401.pdf 6 13 separator 0.93977404 ¶ 610 612 W4310474401.pdf 6 14 table 0.93331605 "bVitamin Premix (mg/kg diet): vitamin A, 16000 IU; vitamin D3, 8000 IU; vitamin K3, 14.72; vitamin B1, 17.80; vitamin B2, 48; vitamin B6, 29.52; vitamin B12, 0.24; vitamin E, 160; vitamin C, 800; niacinamide, 79.20; calcium-pantothenate, 73.60; folic acid, 6.40; biotin, 0.64; inositol, 320; choline chloride, 1500; L-carnitine, 100." 612 952 W4310474401.pdf 6 15 separator 0.6756592 ¶ 952 954 W4310474401.pdf 6 16 table 0.8401331 "cMineral Premix (mg/kg diet): Cu (CuSO4), 2.00; Zn (ZnSO4), 34.4; Mn (MnSO4), 6.20; Fe (FeSO4), 21.10; I (Ca (IO3)2), 1.63; Se (Na2SeO3), 0.18; Co (CoCl2), 0.24; Mg (MgSO4·H2O), 52.7." 954 1140 W4310474401.pdf 6 17 separator 0.97104216 ¶ 1140 1142 W4310474401.pdf 6 18 text 0.7679801 "dSupplied by Symrise Aqua Feed (Elven, France and Part of Symrise Taste, Nutrition & Health segment)." 1142 1246 W4310474401.pdf 6 0 paratext 0.6582068 Análise da viabilidade econ ômica da previsão de cheias... 0 58 W4383422126.pdf 9 1 separator 0.9475746 ¶ 60 62 W4383422126.pdf 9 2 paratext 0.6300333 Non 62 66 W4383422126.pdf 9 3 bibliography 0.65226346 nemacher, L.C., & Fan, F.M. 66 93 W4383422126.pdf 9 4 separator 0.9387103 ¶ ¶ 95 101 W4383422126.pdf 9 5 paratext 0.9348625 Rev. Gest. Água Am. Lat., Porto Alegre , v. 20, e8, 2023 10/15 101 165 W4383422126.pdf 9 6 text 0.9992927 "Portanto, a quantidade total de estações subtrai a área urbana do restante do estado, de forma que a mesma região não seja contabilizada duas vezes. A Tabela 5 apresenta a quantidade fina l de estações para cada classe, totalizando 117 estações. Para fins de segurança, como haver falha ou danos a alguma estação, serão contabilizadas 120 estações. No entanto, sabe -se que na região Nordeste há a Formação Serra Geral, onde há grandes declivida des, as quais não foram contempladas pela resolução do mapa utilizado. A fim de garantir segurança a estas áreas, considerou -se um total de 150 estações, de forma a ser distribuída uma maior quantidade por essas regiões." 165 852 W4383422126.pdf 9 7 separator 0.9969493 ¶ 854 856 W4383422126.pdf 9 8 title 0.7712825 Tabela 5. Número de estações 856 885 W4383422126.pdf 9 9 table 0.50438005 tele 885 890 W4383422126.pdf 9 10 title 0.53742975 métrica 890 897 W4383422126.pdf 9 11 table 0.961931 "s necessárias. Classe Área total (km2) Área por estação (km2) Número de estações Urbana 1.415 20 71 Costeira 33.000 9.000 4 Plana ou suavemente ondulada 237.711 5.750 42" 897 1089 W4383422126.pdf 9 12 separator 0.99075747 ¶ 1090 1092 W4383422126.pdf 9 13 text 0.99903727 "Os custos para a implantação da nova rede hidrometeorológica envolvem o custo com o equipamento, as taxas de importação, visto que os preços no exterior geralmente são mais baixos, e a mão de obra para a instalação. Estes valores foram definidos com base no orçamento da última compra de duas estações meteorológicas realizada pela Universidade Federal do Rio Grande do Sul. O equipamento utilizado para os cálculos foi o Wireless Vantage Pro2 TM with Standard Radiation Shield (#6152), da marca Davis Instruments , o qual custa US$ 695,00, equivalente a cerca de R$ 3.748,55, com a cotação de 25/11/2022, com o dólar valendo R$ 5,39. As taxas a serem consideradas, em caso de compra por setor público, são as seguintes:" 1092 1821 W4383422126.pdf 9 14 separator 0.8395189 ¶ 1823 1825 W4383422126.pdf 9 15 text 0.97462875 "a. Total de equipamentos: 150 estações totalizam R$ 562.282,50; b. Taxa de variação de 5%: valor contabilizado para possíveis alterações cambiais. Aplicando a taxa ao valor da compra, resulta -se em R$ 28.115,00; c. Taxas bancárias entre os bancos nacionais e exteriores: calculada por uma rela ção de proporção, estimada em R$ 17.392,00; d. Taxas do despachante: calculada por uma relação de proporção, estimada em R$ 181.231,00." 1825 2278 W4383422126.pdf 9 16 separator 0.9807435 ¶ 2280 2282 W4383422126.pdf 9 17 text 0.9994058 "Somando o valor total dos equipamentos com todas as taxas, chega -se a um custo arredondado de 800 mil reais. No entanto , como essas estações não medem o nível da água, é necessária a compra de linígrafos. Para isso, foram contabilizados 150 linígrafos com as mesmas taxas aplicadas às estações meteorológicas. Foi obtido um custo total arredondado para 500 mil reais." 2282 2658 W4383422126.pdf 9 18 separator 0.9750043 ¶ 2660 2662 W4383422126.pdf 9 19 text 0.9961965 "Além do s custos com a compra, é necessário calcular -se o custo com a instalação. Para isso, entram nos cálculos os custos com o material para a base de concreto das estações (cimento, areia e brita) e com as diárias da equipe de instalação, estimados da seguinte forma: a Concreto com proporção 1:1:1: um saco de cimento com 50 kg custa cerca de R$ 22,00 e rende para aproximadamente 10 estações, sendo necessários 12 sacos. Um saco de areia com 20 kg custa R$ 4,00 e rende para 4 estações, sendo necessários 30 sacos. A brita compra -se por metro cúbico, sendo 1 m 3 suficiente e custando R$ 90,00. O valor total é de R$ 474,00; b. A diária da equipe de instalação varia bastante, aqui será considerado o valor de R$ 50,00 por trabalhador. Considerando uma equipe de dois hidrotécnicos, com honorários de R$ 100,00, e seis meses para a instalação de todos os equipamentos, totaliza -se o valor de R$ 306.000,00." 2662 3606 W4383422126.pdf 9 20 separator 0.9805951 ¶ 3608 3610 W4383422126.pdf 9 21 text 0.9993493 "Ainda, para o cálculo da vazão a partir do nível d’água, é necessária a medição periódica de vazões para cada ponto, dev endo ser contabilizado o valor para o equipamento de medição de vazão. No caso do presente estudo, considerou -se que quatro equipamentos são necessários, um ADCP e um Flow Tracker para cada equipe (considerando duas equipes de campo). Portanto, estima -se aqui o valor de 800 mil reais para a compra do equipamento, valor que contempla o custo de aquisição de um ADCP (Acoustic Doppler Current Profiler ) e um Flow Tracker, utilizando como base o orçamento da compra realizada pela ANA. Dessa forma, o valor total arredondado de investimento inicial na nova rede telemétrica será de R$ 2.307.000,00." 3610 4351 W4383422126.pdf 9 22 separator 0.98485744 ¶ 4353 4355 W4383422126.pdf 9 23 text 0.99939954 "Tanto para o ano da instalação da rede quanto para os seguintes, é necessária a realização de idas a campo quatro vezes por ano para coleta de novos dados de vazão e nível para a construção e aprimoramento da curva -chave. Além disso, essas idas a campo também seriam utilizadas para a realização da manutenção da rede. Cada ida a campo considera dois hidrotécnicos com honorário de R$ 100,00 e diárias de R$ 50,00, sendo consi deradas duas equipes que atuem simultaneamente, além" 4355 4842 W4383422126.pdf 9 0 text 0.9990808 "smaller in those girls doing ≥3 h/week of extra- curricular osteogenic sports than in the rest of the sam- ple (girls doing < 3 h/week of extra-curricular sports +girls doing non-osteogenic sports + girls not doing extra-curricular sport). Moreover, the cut-off for time of study (low: <3 h/day and high: ≥3 h/day) was also included in our analyses as in previous studies [14]." 0 387 W1979754604.pdf 7 1 separator 0.9725975 ¶ 387 389 W1979754604.pdf 7 2 text 0.9995948 "Similar results were obtained independently of the chosen cut-off. The analyses of other regions, such aswhole body and lumbar spine showed also similar out- comes. These results suggest the importance of extra- curricular and osteogenic sports in the development ofhealthy bones, especially when sedentary behaviours, such as to stay seated for studying are evident. Similarly, it has been shown that sedentary occupations in adult-hood are associated with an increased risk of hip frac- ture in elderly people [30]." 389 919 W1979754604.pdf 7 3 separator 0.9891093 ¶ 919 921 W1979754604.pdf 7 4 text 0.99954176 "The mechanisms by which sedentary behaviours lead to poor bone health are not well understood. According to a recent literature review [13], sedentary behaviour leads to a rapid increase in bone resorption without con-comitant changes in bone formation, resulting in reduced BMC. The present results indicate that some sedentary behaviours can be more detrimental for bonehealth than others. Both the amount and the pattern of sedentary time may have influence on bone metabolism." 921 1414 W1979754604.pdf 7 5 separator 0.9805659 ¶ 1414 1416 W1979754604.pdf 7 6 text 0.99971586 "In a recent study, we observed that the time studyingwas a good surrogate marker of objectively measured sedentary time (the higher the time studying the higher the time spent sedentary) in a large sample of Europeanadolescents [19]. Moreover, sitting is common when a subject is studying or surfing internet. Compared with other sedentary activities, these activities are character-ized by spending a lot of minutes in the same position." 1416 1863 W1979754604.pdf 7 7 separator 0.83372647 ¶ 1863 1865 W1979754604.pdf 7 8 text 0.99959815 "As a result of this, an excessive time without mechanical loading could be detrimental for bone health. We en-courage adolescents to practice extra-curricular osteo- genic sports at least 3 h/week in order to break the sedentary time caused by some sedentary behaviourssuch as study." 1865 2155 W1979754604.pdf 7 9 separator 0.99627984 ¶ 2155 2157 W1979754604.pdf 7 10 title 0.9919621 Limitations and strengths 2157 2183 W1979754604.pdf 7 11 separator 0.995438 ¶ 2183 2185 W1979754604.pdf 7 12 text 0.9997072 "Although we controlled for several potential confoun- ders we cannot be certain that other unmeasured con- founders have not influenced our observations. Ourstudy focus on adolescents from Zaragoza, Spain, since bone mass by DXA was only assessed in this sub-sample of the HELENA-CSS, so the conclusions cannot be gen-eralized to whatever population. Cross-sectional studies only can provide suggestive evidence concerning causal relationships. However, in this specific case, it seems rea-sonable to think that time spent on sedentary behaviours could influence BMC, whereas it is not so clear themechanisms by which bone mass could determine the time spent on sedentary behaviours." 2185 2885 W1979754604.pdf 7 13 separator 0.96239924 ¶ 2885 2887 W1979754604.pdf 7 14 text 0.99968374 "The use of sophisticated methods, such as DXA to as- sess body composition, and the use of accelerometers to assess PA are strengths of the study. In addition, this study includes a rather complete set of confounders, i.e.height, sexual maturation, lean mass and MVPA, which is crucial to examine the current research question." 2887 3223 W1979754604.pdf 7 15 separator 0.9971838 ¶ 3223 3225 W1979754604.pdf 7 16 title 0.9901632 Conclusion 3225 3236 W1979754604.pdf 7 17 separator 0.9958352 ¶ 3236 3238 W1979754604.pdf 7 18 text 0.9995965 "The results of this report indicate that some sedentary behaviour, such as the use of internet for non-study (in boys) and the time spent studying (in girls) are negatively associated with whole body and femoralneck BMC, respectively. In addition, at least 3 h/week of extra-curricular osteogenic sports may help to coun- teract the negative association of time spent studyingon bone health in girls. Additional studies (with a longitudinal or intervention design) must determine with more accuracy the public health importance ofthese findings." 3238 3798 W1979754604.pdf 7 19 separator 0.99669456 ¶ 3798 3800 W1979754604.pdf 7 20 title 0.98818076 Competing interests 3800 3820 W1979754604.pdf 7 21 separator 0.9937134 ¶ 3820 3822 W1979754604.pdf 7 22 text 0.9945732 The authors declare that they have no competing interests. 3822 3881 W1979754604.pdf 7 23 separator 0.99451673 ¶ 3881 3883 W1979754604.pdf 7 24 title 0.9854004 Authors ’contributions 3883 3906 W1979754604.pdf 7 25 separator 0.9906266 ¶ 3906 3908 W1979754604.pdf 7 26 text 0.9991326 "All the authors have substantially contributed to this work: LGM, JPRL, LAM and GVR designed research; LGM, JPRL, LAM and GVR conducted research; LGM, JPRL and GVR performed statistical analysis; LGM and JPRL wrotepaper; LGM, JPRL, LAM and GVR had primary responsibility for final content.All authors have read and approved the final manuscript." 3908 4258 W1979754604.pdf 7 27 separator 0.9971844 ¶ 4258 4260 W1979754604.pdf 7 28 title 0.98305863 Acknowledgements 4260 4277 W1979754604.pdf 7 29 separator 0.9949479 ¶ 4277 4279 W1979754604.pdf 7 30 text 0.99643856 "The HELENA-CSS takes place with the financial support of the European Community Sixth RTD Framework Program (Contract FOOD-CT-2005-007034). This study was also supported by the following grants: Beca de la FundaciónCuenca Villoro (Spain) and JCI-2010-07055. We gratefully acknowledge allparticipating adolescents and their parents for their collaboration. All the authors have substantially contributed to this work." 4279 4702 W1979754604.pdf 7 31 separator 0.99661607 ¶ 4702 4704 W1979754604.pdf 7 32 title 0.6338285 Author details 4704 4719 W1979754604.pdf 7 33 separator 0.96657515 ¶ 4719 4721 W1979754604.pdf 7 34 contact 0.9910865 "1School of Sport and Health Sciences, University of Exeter, Heavitree Road, Exeter EX1 2LU, UK.2GENUD (Growth, Exercise, NUtrition and Development) Research Group, University of Zaragoza, Zaragoza, Spain.3Children Institute, School of Medicine, University of São Paulo, São Paulo, Brazil.4Facultad de Ciencias de la Salud, Universidad de Zaragoza, C/Domingo Miral s/n, 50009 Zaragoza, Spain.5Department of Physiology, School of Medicine, University of Granada, Granada, Spain.6Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute of Food Science, Technology andNutrition (ICTAN), Spanish National Research Council (CSIC), Madrid, Spain." 4721 5401 W1979754604.pdf 7 35 separator 0.5288027 5401 5402 W1979754604.pdf 7 36 contact 0.9831643 "¶ 7Faculty of Health and Sport Science (FCSD), Department of Physiatry and Nursing, University of Zaragoza, Ronda Misericordia 5, 22001 Huesca, Spain." 5402 5554 W1979754604.pdf 7 37 separator 0.9220963 ¶ 5554 5556 W1979754604.pdf 7 38 paratext 0.98321825 "Received: 26 March 2012 Accepted: 24 October 2012 Published: 13 November 2012" 5556 5636 W1979754604.pdf 7 39 separator 0.98288536 ¶ 5636 5638 W1979754604.pdf 7 40 title 0.8533236 References 5638 5649 W1979754604.pdf 7 41 separator 0.9896194 ¶ 5649 5651 W1979754604.pdf 7 42 bibliography 0.9954624 "1. Rizzoli R, Bianchi ML, Garabedian M, McKay HA, Moreno LA: Maximizing bone mineral mass gain during growth for the prevention of fractures inthe adolescents and the elderly. Bone 2010, 46:294–305. 2. Zofkova I: Role of genetics in prediction of osteoporosis risk. Vnitr Lek 2011, 57:78–84." 5651 5949 W1979754604.pdf 7 43 separator 0.94852746 ¶ 5949 5951 W1979754604.pdf 7 44 bibliography 0.9954727 "3. Gracia-Marco L, Moreno LA, Ortega FB, Leon F, Sioen I, Kafatos A, Martinez- Gomez D, Widhalm K, Castillo MJ, Vicente-Rodriguez G: Levels of PhysicalGracia-Marco et al. BMC Public Health 2012, 12:971 Page" 5951 6160 W1979754604.pdf 7 45 paratext 0.62287015 8 6160 6162 W1979754604.pdf 7 46 bibliography 0.525365 of 9 6162 6167 W1979754604.pdf 7 47 separator 0.9430183 ¶ 6167 6169 W1979754604.pdf 7 48 bibliography 0.6564116 http://www.biomed 6169 6187 W1979754604.pdf 7 49 paratext 0.67329973 central.com/1471-2458/12/971 6187 6215 W1979754604.pdf 7 0 caption 0.9933266 Fig. 1. Lensless microscopy setup and object fitting. 0 52 W4297934697.pdf 1 1 separator 0.97178423 ¶ 52 54 W4297934697.pdf 1 2 title 0.5465782 Maximum likelihood 54 73 W4297934697.pdf 1 3 caption 0.4797606 estim 73 79 W4297934697.pdf 1 4 title 0.48355895 ation of 79 87 W4297934697.pdf 1 5 caption 0.37166598 the 87 91 W4297934697.pdf 1 6 title 0.3492929 91 92 W4297934697.pdf 1 7 text 0.52519035 parameters of 92 106 W4297934697.pdf 1 8 separator 0.5443773 ¶ 106 108 W4297934697.pdf 1 9 text 0.8967713 "the object of interest, under the hypothesis of additive white Gaussian noise, amounts to solving a nonlinear least-squares problem [3]:" 108 249 W4297934697.pdf 1 10 separator 0.74714136 ¶ 249 251 W4297934697.pdf 1 11 math 0.86113155 "^(ML)=arg min AX a=1BX b=1w(a;b)[m(a;b)" 251 301 W4297934697.pdf 1 0 text 0.98926026 "Anderson al. Granger causality and connection strength overcome these biases,but the predispositions for action are still revealed by the time it takes us to act. As an example, when shown the word “three” we can either read it aloud or report its parity, and we can do the same when shown the numeral “3.”" 0 314 W1997264248.pdf 1 1 separator 0.94656605 ¶ 314 316 W1997264248.pdf 1 2 text 0.9996464 "It turns out that the time to respond interacts with the nature of the format and reveals the omnipresent effect of a stimulus- task predisposition. Besner et al. (2011) found that participants weremuchfasteratmakingparityjudgmentstoArabicnumerals thantonumberspresentedalphabetically(hereafterreferredtoas “numberwords”),buttookaboutthesameamountoftimewhen reading/naming these different stimuli aloud1.T oe x p l a i nt h e i r findings,Besneretal. (2011)proposedageneralaccountinwhich there are various special purpose modules, each of which com- putes specific information-processing routines. An example of suchanaccountcanbeseenin Figure 1,whichisadaptedinlarge part from several well known and highly successful computa- tionalaccountsofreadingaloud(e.g., Coltheartetal.,2001 ;Perry et al., 2007 ). The lexical representations are localist and linguis- tic in nature. Each node in the alphabetic input lexicon consists of the spelling of a word known to the reader. The nodes in theArabicinputlexiconrepresent,minimally,eachsingleArabic numeralfrom0to9.Thesemanticsystemisconceptualandcon- tains general knowledge of the world. Both input lexicons and the semantic system also activate the phonological output lexi- con, whichcontains information abouthoweachitemthereader knows should be pronounced. The additional but theoretically central point here is that the strength of the format-task associ- ations reflects both predispositions (some format-task pairings are more natural and experienced than others; Figure 1A ), and task-induced modulation of the routes connecting the relevant cognitivemodules( Figure 1B )." 316 1991 W1997264248.pdf 1 3 separator 0.9814049 ¶ 1991 1993 W1997264248.pdf 1 4 text 0.9995509 "This account differs from previous accounts in its emphasis ontheassertionthattheconnections betweendifferentrepresen- tations differ in strength. The Arabic numeral format (an input module) is more strongly associated with semantics than is the number word format (hence parity judgments are faster for theformer than the latter). In contrast, the number word format (input module) is more strongly associated with phonology, as compared to Arabic numerals. Indeed, so strongly that it over- comesthefactthatArabicnumeralsaremorefrequentlyencoun- tered in the world than are their number word counterparts (and hence Arabic numerals, despite the fact that they are more frequent than their number word counterparts, are not named faster). Such a framework implies the need for some sort of mediator that functions as an arbiter of task demands.Such task demand units (e.g., see the seminal paper by Cohen et al., 1990 ) could favorsomemodulesoverothers (e.g., by inhibition and/or activation),and/ormodulatethestrengthofconnectionsbetween different modules (see also Norman and Shallice, 1986 ;Monsell" 1993 3124 W1997264248.pdf 1 5 separator 0.9725969 ¶ 3124 3126 W1997264248.pdf 1 6 text 0.995212 "1Support for this strength of connections account has been reported by Adelman et al.(2014) who compared two versions of a computational model for reading words aloud. The model in which word frequency affects the strength of con- nections (stronger for high- than low-f requency words) between an orthographic input lexicon and a phonological output lexicon accounts for more variance inreading aloud response times than does the otherwise identical model in which wordfrequencyaffectstherestinglevelsofactivation(higherrestinglevelsforhigh- than low-frequencywords)inthesesamemodules.and Driver, 2000 ;Kane and Engle, 2003 ). Seeking converging evidence to support this hypothesis, the present work assessed whether this cognitive account has a neurological correlate by measuringchangesinfunctional connectivity infunctional mag- netic resonance imaging (fMRI) scans of participants engagedin ourreading/parity taskswithnumberwordsandArabicnumeral stimuli." 3126 4108 W1997264248.pdf 1 7 separator 0.98930335 ¶ 4108 4110 W1997264248.pdf 1 8 title 0.96580505 "Choosing a Functional Analysis Methodology" 4110 4155 W1997264248.pdf 1 9 separator 0.9871906 ¶ 4155 4157 W1997264248.pdf 1 10 text 0.9975305 "Earlierweproposedthattheremustbechangesintheconnection strengthbetweenmodulesthataremodulatedbycombinationsof task demands and stimulus characteristics ( Besner et al., 2011 ). To provide evidence for our claim, we repeated our behavioral task while performing fMRI. We were specifically interested in whether we could observe changes in cortical functional con- nectivity for particular task-stimulus combinations. While thecognitive model per seis agnostic about underlying cortical anatomical localization, the claim about changes in connectiv- ity is more generic. As long as the brain is the physical substrate implementing the cognitive comp onents, functional changes in cognitivemoduleconnectivityshouldproducesomecorrespond- ing changes in brain signals. The key question is whether the brainchangesoccurforparticular task-stimulussetcombinations that are predicted by the cognitive model, rather than whether the brain changes occur in particular brain regions. However, if changes are found, the knowledge about the localization of cog- nitivefunctionsfrompriorfunctionalimagingworkdoesprovide apowerfulcheckontheplausibilitythatthechangesinfunctional connectivity aremeaningful." 4157 5383 W1997264248.pdf 1 11 separator 0.97052944 ¶ 5383 5385 W1997264248.pdf 1 12 text 0.99948263 "Functional connectivity assessments in fMRI are relatively new, and there are several available procedures, and no one method has been clearly established as superior to the others (Rogers et al., 2007 ). Therefore, the choice of which one is used rests to a large extent on the familiarity and experience of the researchers involved. Perhaps the only real choice is whetherthereissufficient aprioriinformation availableto warrant estab- lishingacausalmodelinadvanceofexperimentalmeasurements." 5385 5889 W1997264248.pdf 1 13 separator 0.8584908 ¶ 5889 5891 W1997264248.pdf 1 14 text 0.9993329 "Ifnot,andtheexperimentislargelyexploratory thenmostof the available methods could be justified, though as will be reviewed shortly, only the Grangermetric offers the potential for support- ing a claim about the causal nature of the relation between two brainregions." 5891 6164 W1997264248.pdf 1 15 separator 0.96044064 ¶ 6164 6166 W1997264248.pdf 1 16 text 0.9995844 "Essentially, functional connectivity is a way of measuring to what degree different voxels from a series of functional images move in sync together. Procedures for measuring this type of functionalconnectivity includeGCM,psychophysiological inter- action (PPI), and various graph theoretic measures. The excep- tion to this approach may be dyn amic causal modeling (DCM) where the emphasis is more on comparing particular models of brain module connectivity than exploring what voxels show activationpatternsthatarecorrelated." 6166 6708 W1997264248.pdf 1 17 separator 0.89088535 ¶ 6708 6710 W1997264248.pdf 1 18 text 0.99697584 "One of the more direct approaches to functional connectiv- ity is the graph theoretic ( Cao et al., 2014 ). For this technique (Bullmore and Bassett, 2011 ) the BOLD signal for each voxel can be assessed over time. These time series are then corre- lated against each other to see which voxels are correlated with ¶" 6710 7034 W1997264248.pdf 1 19 paratext 0.98472065 Frontiers in Psychology | www.frontiersin.org 2 March 2015 | Volume 6 | Article 321 7034 7118 W1997264248.pdf 1 0 paratext 0.95340514 "SABINO, 1\1:.&ZORZETTO, M.A.P. -Separação equantificação dasaflatoxinas B""B2>G,eG2por cromatografia líquida dealtaresolução. Rev.Lnst:Adolfo Lutz,44(2):101-108, 1984." 0 168 W4392437139.pdf 1 1 separator 0.99527395 ¶ 168 170 W4392437139.pdf 1 2 title 0.8688199 Solvenies 170 180 W4392437139.pdf 1 3 table 0.8864913 "¶ Metanol p.a. Clorofórmio p.a. Solução decloreto desódioa40/0 Hexano p.a. Metanol Lichrosolv Acetonitrila Lichrosolv Águadestilada, filtrada emfiltroMillipQ'í-e emmembrana filtrante de0,8/Ldeporo (47mmdediâmetro) ref.AAWP, 04700." 180 427 W4392437139.pdf 1 4 separator 0.99416256 ¶ 427 429 W4392437139.pdf 1 5 title 0.64234006 Soluções-padrão dasaf'latoxl 429 458 W4392437139.pdf 1 6 table 0.8763198 "nas BJ, B2'G"" G2emmetanol Lichrosolv Fasemóvel Aáguadestilada Bacetonitrila +metanol (3+2) sendoIAlB65% 35r;1o" 458 580 W4392437139.pdf 1 7 separator 0.9800488 ¶ 580 582 W4392437139.pdf 1 8 title 0.75274515 Aparelho 582 591 W4392437139.pdf 1 9 separator 0.86293304 ¶ 591 593 W4392437139.pdf 1 10 text 0.976502 "Cromatógrafo automático líquido dealta resolução, cominjetor automático (variá- vel),modo1084A,comsistema gradien- te,acoplado comdetetor variável, U.V., visível, H.P.,modo1030B,comprogra- mador modo79850A-LC, terminal HP" 593 825 W4392437139.pdf 1 11 separator 0.5697698 ¶ 825 827 W4392437139.pdf 1 12 text 0.6721789 "Coluna: Lichrosorb RP18-10um (Merck) ¶" 827 868 W4392437139.pdf 1 13 table 0.4988369 Fras 868 873 W4392437139.pdf 1 14 text 0.55934983 co: de2mlHP 873 884 W4392437139.pdf 1 15 separator 0.9961838 ¶ 884 886 W4392437139.pdf 1 16 title 0.98586065 MÉTODO 886 893 W4392437139.pdf 1 17 separator 0.99490404 ¶ 893 895 W4392437139.pdf 1 18 text 0.9906713 "Adeterminação dasaflatoxinas envolve as seguintes operações:" 895 958 W4392437139.pdf 1 19 separator 0.9465536 ¶ 958 960 W4392437139.pdf 1 20 text 0.7558919 a)Pre 960 966 W4392437139.pdf 1 21 title 0.5825513 par 966 969 W4392437139.pdf 1 22 text 0.58664244 o daamostra 969 980 W4392437139.pdf 1 23 separator 0.8742207 ¶ 980 982 W4392437139.pdf 1 24 text 0.9968004 "Descascar (seforocaso) etriturar a amostra. Proceder aumaperfeita homoge- neização damesma." 982 1078 W4392437139.pdf 1 25 separator 0.96503913 ¶ 1078 1080 W4392437139.pdf 1 26 text 0.63735706 b)Extração das 1080 1095 W4392437139.pdf 1 27 title 0.6325459 ailatoxina 1095 1105 W4392437139.pdf 1 28 text 0.575297 e 1105 1106 W4392437139.pdf 1 29 separator 0.9056411 ¶ 1106 1108 W4392437139.pdf 1 30 text 0.9947672 "Pesar30gdaamostra etransferir para umfrasco Erlenmeyer de250mlcomtampa esmerilhada. Adicionar àamostra 10mlde águaehomogeneizar combastonete devidro; adicionar 100mldeclorofórmio, fechar o frasco eagitar violentamente durante 30 segundos. Continuar agitando emagitador mecânico por30minutos oumais.Filtrar o extrato empapeldefiltroWhatman n.?1 ouequivalente. Afiltração decertosmate- riais,particularmente amendoim, podeser muitolentaedifícil. Paraevitarestepro- blema, éconveniente filtrar através deuma camada deterradiatornácea, talcomo""Celi- te"".Minimizar aevaporação doclorofórmio cobrindo ofunilcomvidroderelógio efolha depapeldealumínio. Evaporar ofiltrado até oresíduo. Dissolver esteresíduo em50ml demetanol p.a.,transferir parafunilde 102separação de500ml.Adicional 50mldeelo- retodesódioa4%eagitar. Extrair com3 porções de50mldehexano cadapararemo- veragordura. Desprezar ohexano. Extrair comduasporções de50mldeclorofórmio." 1108 2090 W4392437139.pdf 1 31 separator 0.84097 ¶ 2090 2092 W4392437139.pdf 1 32 text 0.9932228 "Evaporar oextrato clorofórmico atéoresí- duo.Transferir oresíduo quantitativamente comclorofórmio parafrasco de2ml,evapo- rarsobgásdenitrogênio atéresíduo. Guar- daremgeladeira, sobproteção daluz,até omomento deusar." 2092 2319 W4392437139.pdf 1 33 separator 0.9968925 ¶ 2319 2321 W4392437139.pdf 1 34 title 0.9841995 c)Cromatoçrafia líquida dealtaresolução 2321 2361 W4392437139.pdf 1 35 separator 0.991655 ¶ 2361 2363 W4392437139.pdf 1 36 text 0.9899383 "Dissolver oresíduo obtido etransferir paraofrascodopróprio aparelho com2ml demetanol Lichrosolv. Injetar estasolução nocromatógrafo paraidentificação equan- tificação dasaflatoxinas." 2363 2554 W4392437139.pdf 1 37 separator 0.9961877 ¶ 2554 2556 W4392437139.pdf 1 38 title 0.8210117 Programação deoperação-coluna (RP 2556 2590 W4392437139.pdf 1 39 table 0.9664111 "18) Fasemóvel acetonitrila-metanol (3+2) -água(35+65%) Detetor: U.V.(350nm) Fluxo: 2,0ml/minuto Injeção:50/LI Sensibilidade: 0,05 Atenuação: ATTN 2 Temperatura doforno: ambiente" 2590 2783 W4392437139.pdf 1 40 separator 0.990299 ¶ 2783 2785 W4392437139.pdf 1 41 text 0.99556017 "Asaflatoxinas sãodetectadas porabsor- çãonoU.V.a350nm,equantificadas pela áreadospicosobtidos comparada àáreados picosdassoluções-padrão." 2785 2929 W4392437139.pdf 1 42 separator 0.90602124 ¶ 2929 2931 W4392437139.pdf 1 43 text 0.9959515 "Asafiatoxinas sãodetectadas porabsor- çãonoU.V.a350nm,equantificadas pela áreadospicosobtidos comparada àáreados picosdassoluções-padrão, segundo af'ór- mula:" 2931 3098 W4392437139.pdf 1 44 separator 0.9208106 ¶ 3098 3100 W4392437139.pdf 1 45 table 0.9316072 "AxXCsXVsXSD AsXVxXWaflatoxinas (/Lg/kg) Ax áreaintegrada daaflatoxina (B"" B2'G""G2) CSconcentração daafiatoxina-padrão (/Lg/ml) Vs=/LIdasolução-padrão injetada SDdiluição finaldoextrato daamostra em/LI Asáreaintegrada dasolução-padrão Vx.-/LIdoextrato daamostra injetada Wpesodaamostra representado pelo volume doextrato utilizado por CLAR" 3100 3465 W4392437139.pdf 1 46 separator 0.9954044 ¶ 3465 3467 W4392437139.pdf 1 47 title 0.9878666 RESULTADOS 3467 3478 W4392437139.pdf 1 48 separator 0.99569017 ¶ 3478 3480 W4392437139.pdf 1 49 text 0.99856865 "As4aflatoxinas BJ, B2,GleG2foram resolvidas porCLAR em15minutos edetec- tadasnoU.V.a350nm.Os4compostos" 3480 3587 W4392437139.pdf 1 50 separator 0.95761526 ¶ 3587 3589 W4392437139.pdf 1 0 paratext 0.9780323 "Bugallo VL , Facciuto GR & Poggio L4 of 9 Rodriguésia 74: e00872022 . 2023" 0 77 W4386831856.pdf 3 1 separator 0.95681477 ¶ 77 79 W4386831856.pdf 3 2 text 0.99590445 "a caliber and registered in millimeters. Estimation of the mean leaf area was made by means of the measurement of this parameter in a Green Leaf Area Meter GA-5 (Tokio Photoelectrics) in at least 10 leaves for genotype." 79 311 W4386831856.pdf 3 3 separator 0.995836 ¶ 311 313 W4386831856.pdf 3 4 title 0.99227095 "Comparison between genome size, cytological and phenotype characters" 313 385 W4386831856.pdf 3 5 separator 0.9895909 ¶ 385 387 W4386831856.pdf 3 6 text 0.99962515 "The comparisons between the genomic size and the phenotypic characters obtained in this work, as well as with previously published cytological characters (Bugallo et al. 2020; Kew 2021), were made through regressions to establish correlations." 387 643 W4386831856.pdf 3 7 separator 0.9967382 ¶ 643 645 W4386831856.pdf 3 8 title 0.9919326 Statistical design and analysis 645 677 W4386831856.pdf 3 9 separator 0.99317956 ¶ 677 679 W4386831856.pdf 3 10 text 0.9996233 "The hypothesis of similarity of means 1Cx value, flower diameter, leaf area and internodal length between the different genotypes and taxa of Passiflora was verified according to an F-test (ANOV A) in a completely randomized design and they were compared by means of a Between Sum of Squares (BSS) statistical test with significance level p 0.05. Correlations between characters were studied by means of linear regressions. All statistical analyses have been performed with the InfoStat package (version 2009, National University of Córdoba, Argentina) (Di Rienzo et al. 2010)." 679 1294 W4386831856.pdf 3 11 separator 0.99666506 ¶ 1294 1296 W4386831856.pdf 3 12 title 0.9383426 Results 1296 1304 W4386831856.pdf 3 13 separator 0.9942063 ¶ 1304 1306 W4386831856.pdf 3 14 text 0.9993188 "As a result of the flow cytometric analysis, histograms of the relative content of nuclear DNA of Argentinean genotypes of Passiflora and Hordeum vulgare cv. New Golden were obtained. The amount of 1Cx DNA estimated for Passiflora taxa from Argentina ranged between 0.54 and 2.52 picograms in P . capsularis and P. alata species, respectively ( Tab. S2, available on supplementary material < https://doi.org/10.6084/ m9.figshare.23905617.v1 >)." 1306 1783 W4386831856.pdf 3 15 separator 0.96216345 ¶ 1783 1785 W4386831856.pdf 3 16 text 0.9992899 "The BSS statistical comparison carried out between the analyzed taxa showed the existence of similarity between the sizes of the genomes in the Decaloba and Dysosmia subgenus species, differing with the Passiflora subgenus species, which presented higher amounts of DNA. Comparison among the amounts of DNA in the monoploid complements (1Cx) of the taxa allowed the recognition of five groups: a) P . capsularis , P . suberosa , P . morifolia and P. foetida with 0.54 to 0.72 picograms of DNA per genome; b) P . tucumanensis with 0.91 pg.; c) P . elegans and P . cincinnata with 1.29 and 1.35 pg.; d) P . edulis f. edulis , P . edulis f. flavicarpa , P . caerulea , P . mooreana (diploid and tetraploid) and P . amethystina with 1.52 to 1.76 pg., e) P. alata with 2.52 pg. This analysis differentiated the Passiflora subgenus, which presented a greater amount of DNA in its genome (0.91 to 2.52 pg.), from the Dysosmia and Decaloba subgenera (0.54 to 0.72 pg.)." 1785 2818 W4386831856.pdf 3 17 separator 0.9775888 ¶ 2818 2820 W4386831856.pdf 3 18 text 0.99973357 "Within the subgenus Passiflora , there was variation between the C values of the different taxa. In addition, intraspecific differences in the size of the genomes were recorded in the species P. caerulea , P . elegans and P . edulis f. flavicarpa . The species with the highest number of genotypes in this work was P . caerulea , of which 10 accessions were studied. There were found 3 different statistical groups (ANOV A-BSS) and a variation from 1.33 to 1.80 pg. of DNA per haploid genome." 2820 3342 W4386831856.pdf 3 19 separator 0.9728358 ¶ 3343 3345 W4386831856.pdf 3 20 text 0.999632 "In the studied species of Passiflora , variation in the phenotypic characters, flower diameter, length of internodes and leaf area were found ( Tab. S2, available on supplementary material < https:// doi.org/10.6084/m9.figshare.23905617.v1 >). In linear regression studies (Fig. 1), genome size (Cx value) and flower diameter correlated significantly (R2 = 0.75), as well as leaf area and flower diameter (R2 = 0.58). Correlations of less than 0.5 were found between genome size and leaf area (R2 = 0.40), and between the length of the internodes and the rest of the studied characters: with the leaf area (R2 = 0.31), with genome size (R2 = 0.15) and flower diameter (R2 = 0.13). The three phenotypic characters studied in this work, flower diameter, leaf area and length of internodes, showed intra and inter-specific variation." 3345 4223 W4386831856.pdf 3 21 separator 0.9785491 ¶ 4223 4225 W4386831856.pdf 3 22 text 0.9997241 "A linear regression was performed between the total length of the genome, estimated by measuring the chromosomes in the genotypes of the collection (Bugallo et al . 2020), and the amount of DNA per haploid genome estimated in this work. The results showed that the two variables were closely correlated, with a coefficient of determination R2 = 0.95 (Fig. 1). When the total length of the genome was compared with the estimated genomic sizes for other genotypes of these species, known prior to this work, the same correlation was found (R2 = 0.95)." 4225 4808 W4386831856.pdf 3 23 separator 0.99693567 ¶ 4809 4811 W4386831856.pdf 3 24 title 0.9908756 Discussion 4811 4822 W4386831856.pdf 3 25 separator 0.99544495 ¶ 4822 4824 W4386831856.pdf 3 26 text 0.9992576 "In this work, the nuclear DNA content of 30 genotypes corresponding to 13 taxa of" 4824 4909 W4386831856.pdf 3 0 title 0.98281485 2. Main points of this book 0 27 W2884489219.pdf 2 1 separator 0.9947277 ¶ 27 29 W2884489219.pdf 2 2 text 0.9995851 "Technological change is one of the greatest issues in the modern world. As the world faces societal challenges, for example, climate challenges, aging problem, and energy security, tech - nology will contribute to new or better solutions for those problems. New technologies take longer to develop and mature; moreover which tend to be born in the interconnection of mul - tiple technology fields, therefore early detection of emerging technological concepts across multiple disciplines will be a very important issue." 29 561 W2884489219.pdf 2 3 separator 0.9032452 ¶ 561 563 W2884489219.pdf 2 4 text 0.9951448 "Our goal is to seek to develop automated methods that aid the systematic, continuous and comprehensive assessment of technological emergence using one of the major foresight exercises, scientometrics. There is now a huge flood of scientific and technical information, especially scientific publications and patent information. Using the information patterns of emergence for technological concepts have been discovered and theories of technical emer - gence have also been developed in several years. We have been developing visualization tools that thousands of technical areas have been interacted with each other and evolved in time. Several indicators of technical emergence have been improved by universities, international organizations, and funding agencies." 563 1352 W2884489219.pdf 2 5 separator 0.96506816 ¶ 1352 1354 W2884489219.pdf 2 6 text 0.9987548 "This book intends to provide readers a comprehensive overview of the current state-of-the-art in scientometrics, focusing on the systematic, continuous and comprehensive assessment of technological emergence. This book is composed of 12 chapters by cutting-of-edge authors of many different nationalities from Europe to Asia." 1354 1689 W2884489219.pdf 2 7 separator 0.87903965 ¶ 1689 1691 W2884489219.pdf 2 8 text 0.99924415 "Especially the chapter “Mapping Science based on research content similarity” by Dr Kawa- mura shows an interesting methodology for analyzing publications based on an adaptation of word embedding and paragraph embedding with an entropy-based word clustering meth - odology. The proposed combination of word embedding and entropy-based approach is very useful for the scientometrics community." 1691 2094 W2884489219.pdf 2 9 separator 0.99709916 ¶ 2094 2096 W2884489219.pdf 2 10 title 0.992376 3. Conclusions and future perspective 2096 2134 W2884489219.pdf 2 11 separator 0.99600625 ¶ 2134 2136 W2884489219.pdf 2 12 text 0.9995026 "Last but not least, we would like to mention an expected future landscape of this field. Now it is evolutionary time from basic research phase to implementation phase and scientometrics will be expected to be applied to the fields below at the implementation level." 2136 2408 W2884489219.pdf 2 13 separator 0.9970771 ¶ 2408 2410 W2884489219.pdf 2 14 title 0.99146056 3.1. IP landscape 2410 2428 W2884489219.pdf 2 15 separator 0.9966284 ¶ 2428 2430 W2884489219.pdf 2 16 text 0.99753195 "Recently “IP landscape” has been referred in the field of intangible assets. IP landscape pro - vides not only a snapshot but also a strategic analysis of the IP trends of a specific technology field within either a given company or a given country. It is said that the techniques or tools in scientometrics are very useful for the needs of IP landscape as following: (i) understanding of IP for products and technologies, (ii) building a simple model,Scientometrics" 2430 2909 W2884489219.pdf 2 17 paratext 0.5996045 4 2909 2911 W2884489219.pdf 2 0 text 0.9957304 "2and re-ligating the plasmid. hARGal4ΔTAU5/whtlf+, hARGal4ΔTAU5/ahtaa+, hARGal4ΔTAU5/2Xwhtlf+, and hARGal4ΔTAU5/3Xwhtlf+ were generated by inserting synthetic double-stranded cassettes with flanking BssH II sites into BssH II-digested hARGal4ΔTAU5. Fusions between the Gal4 DBD (pM, Clontech) and WHTLF- or AHTAA-containing peptides were cons tructed using the same strategy." 0 389 W4361804907.pdf 1 1 separator 0.97194993 ¶ 390 392 W4361804907.pdf 1 2 text 0.99521005 "Details of the primers used for mutagene sis reactions will be made available upon request. All deletion and point-mutant constructs were sequenced to verify their integrity and tested for expression via transient tran sfection and Western blot with anti-AR and anti-Gal4 antibodies." 393 688 W4361804907.pdf 1 3 separator 0.997061 ¶ 691 693 W4361804907.pdf 1 4 title 0.9756158 Supplemental Figure Legends 693 721 W4361804907.pdf 1 5 separator 0.99678075 ¶ 722 724 W4361804907.pdf 1 6 caption 0.98899686 "Supplemental Figure 1. AR does not display ligand-inde pendent activity in androgen- dependent LNCaP cells. LNCaP cells were transfected with ARE-driven or GAL4- driven, PSA-based reporter construc ts along with wild-type (WT) AR Gal4 or ARGal4 ΔTAU5 as indicated. Cells were grown in serum-free medium for 48h. Luciferase activity was determined. Data represent the mean +/- S.E. from at least three independent experiments, each performed in duplicate. Supplemental Figure 2. TAU5 is dispensable for AR activity in response to 1nM mibolerone in ADI C4-2 cells. C4-2 cells were transfected with MMTV-LUC along with wild-type and ΔTAU5 versions of AR sr as indicated and treated with 1nM Mib or" 724 1453 W4361804907.pdf 1 0 title 0.9007419 352 RELIGIOUS EDUCATION 0 23 W1993529186.pdf 4 1 separator 0.8123987 ¶ 23 25 W1993529186.pdf 4 2 title 0.98702884 FROM THE STANDPOINT OF THE PSYCHOLOGY OF EDUCATION 25 76 W1993529186.pdf 4 3 separator 0.98947084 ¶ 76 78 W1993529186.pdf 4 4 text 0.99946773 "Modern educational psychology challenges society and all its organizations to service in a note that has no uncertain ring. There is no time to do this challenge justice in this brief paper, but there are at least two principles that stand out so clear that we who are concerned about religious education need to sit up and take notice." 78 423 W1993529186.pdf 4 5 separator 0.6673156 ¶ 423 425 W1993529186.pdf 4 6 text 0.99961925 "The first of these is the fact that such things as science, music, ideals of social living, religious philosophies of life, and a few other things that go with culture, can be guaranteed to succeeding gener- ations only on the basis of education. All that heredity and instinct can do is to provide for rudimentary living." 425 756 W1993529186.pdf 4 7 separator 0.9281782 ¶ 756 758 W1993529186.pdf 4 8 text 0.99972373 "After a fashion we have always believed this, otherwise the question of education and schools would be a matter of only yester- day. But we have not believed it in the way that the naked facts revealed by educational psychology compel us to believe it. Conse- quently, we are beginning to realize what plastic beings children are and how completely their futures rest with us. Now and then an individual kicks the traces, but in general, people share the ideas of the home in which they grow up, the school they go to and the com- munity in which they live. If a child is to have the advantage of the best, therefore, he must be given a chance to share the best in his own immediate environment and to share in the remodeling of the community to this end." 758 1536 W1993529186.pdf 4 9 separator 0.95611954 ¶ 1536 1538 W1993529186.pdf 4 10 text 0.9995955 "The second fact established by modern educational psychology is that education is assured only when all instruction is either done through or supplemented by actual participation in the art of doing and living. Learning by rote ethical codes and knowing a catechism forwards and backwards are no more a guarantee of right living and logical theological thinking, than being able to recite the laws of chemistry makes a man a practical chemist. The way to become a chemist is by discovering and verifying chemical law through experiment. And the way to become safe in ethical living and sound in theological thinking is to practice ethical living every day from childhood to old age, and by testing out theological doctrine in human experience. Ethics and religion can be taught, but they are not taught simply when children have been exposed to the sound of their formulae and the sight of their ceremonialism and symbolism." 1538 2489 W1993529186.pdf 4 11 separator 0.9425614 ¶ 2489 2491 W1993529186.pdf 4 12 text 0.99969804 "It is quite true that the contemplation of these things as well as the perfunctory participation in them produces habits of thought and mind that become fixed. This ""set of the mind"" Professor Coe defines as the result of education whether consciously or uncon- sciously directed, but what we want is a ""set of mind"" that is alert." 2491 2831 W1993529186.pdf 4 13 separator 0.9897584 ¶ 2831 2833 W1993529186.pdf 4 14 paratext 0.9063092 Downloaded by [Computing & Library Services, University of Huddersfield] at 14:27 13 January 2015 2833 2931 W1993529186.pdf 4 15 separator 0.9969504 ¶ 2932 2934 W1993529186.pdf 4 0 text 0.9995786 "In mammalian hosts, adult forms of trematodes consume large amounts of glucose to generate and supply energy by running theglycolytic pathway [10]. Adult schistosomes import exogenousglucose, equivalent to their dry body weight every 4 hours fromhost blood by using glucose transporters in their tegumentalmembranes [11,12]. In C. sinensis , glucose transporter and Na +/ glucose co-transporter are expressed abundantly in the adult stagebut less so in the metacercarial stage as presented in the C. sinensis transcriptome [13]. Adult C. sinensis worms uptake glucose to produce energy in the anaerobic environment of the bile duct [14]." 0 647 W1996775489.pdf 1 1 separator 0.932492 ¶ 647 649 W1996775489.pdf 1 2 text 0.9993994 "Therefore, we expected that C. sinensis could be labeled with 2- deoxy-2-[ 18F]fluoro-D-glucose (18F-FDG), a glucose analogue used for the radiolabeling and diagnostic imaging of cancer cells [15].Thus, by ex vivo labeling CsNEJs with 18F-FDG, we hoped their migration in the final host could be traced in vivo by positron emission tomography-computed tomography (PET-CT)." 649 1034 W1996775489.pdf 1 3 separator 0.96371794 ¶ 1034 1036 W1996775489.pdf 1 4 text 0.99881375 "In vivo imaging techniques have strong merits for the no- ninvasive tracing on pathogens moving within tissues of livinganimals, as they involve minimal manipulation and/or euthanasiaof animals, and allow repetitive tracking in same animals.Furthermore, as was found in the present study, these techniquesmake it possible to monitor the distribution and migration ofCsNEJs in vivo from the duodenum to the liver or distal bowel. This study was carried out to determine how CsNEJs find their way and how rapidly they migrate to the intrahepatic bile duct by using in vitro 18F-FDG radiolabeling and PET-CT in a rabbit model." 1036 1670 W1996775489.pdf 1 5 separator 0.99639744 ¶ 1670 1672 W1996775489.pdf 1 6 title 0.99108046 Materials and Methods 1672 1694 W1996775489.pdf 1 7 separator 0.9956978 ¶ 1694 1696 W1996775489.pdf 1 8 title 0.9889624 1. Collection of C. sinensis metacercariae 1696 1739 W1996775489.pdf 1 9 separator 0.99162066 ¶ 1739 1741 W1996775489.pdf 1 10 text 0.9997448 "Topmouth gudgeons ( Pseudorasbora parva ), the second interme- diate host of C. sinensis , were purchased at a fish market in Shenyang, Liaoning Province, People’s Republic of China. Fisheswere ground then digested in artificial gastric juice (8 g of pepsin1:10,000 (MP Biochemicals Co., Solon, OH, USA) and 8 ml ofconcentrated HCl in 1 liter of water) for 2 hr at 37 uC [10]. To remove particulate matters, the digested soup was filtered througha sieve of 212 mm mesh. C. sinensis metacercariae (135–145mm690–100 mm) were then filtered out using seives of 106 and 53 mm meshes and washed thoroughly several times with 0.85% saline. C. sinensis metacercariae were collected under a dissecting microscope and stored in phosphate-buffered saline at 4uC until required [10]." 1741 2529 W1996775489.pdf 1 11 separator 0.99725306 ¶ 2529 2531 W1996775489.pdf 1 12 title 0.9925449 2. Labeling CsNEJs with radio-isotope 2531 2569 W1996775489.pdf 1 13 separator 0.99326456 ¶ 2569 2571 W1996775489.pdf 1 14 text 0.9996237 "The metacercarial cyst wall of C. sinensis is thick and can hinder glucose diffusion. Thus to maximize radiolabeling efficiency, metacercariae were excysted and juvenile worms were liberatedfrom cysts. The C. sinensis metacercariae were excysted by treating them with 0.05% trypsin at 37 uC for 5 minutes (Gibco, Grand Island, NY, USA) in 1 6Locke’s solution (150 mM NaCl, 5 mM KCl, 1.8 mM CaCl 2, 1.9 mM NaHCO 3), a maintaining medium ofCsNEJs [16]. CsNEJs were washed 5 times with 1 6Locke’s solution, and used immediately. CsNEJs were divided into two groups of 10–270 juveniles each; one was of CsNEJs that excysted just before radiolabeling and the other was of the CsNEJs fasted for 24 hours. The two CsNEJ groups were radio-labeled with18F- FDG by incubating them in 1 6Locke’s solution containing 74 MBq18F-FDG at 37 uC for 15, 30, or 60 min. After washing 3 times with 1 6Locke’s solution, radioactivity was measured for 10 min using a PET (GEMINI TF, Philips Healthcare, Cleveland, OH, USA). Numbers of CsNEJs were counted and labeling efficiency was calculated as counts per minute (cpm) divided bynumber of the CsNEJs. Radio-labeling efficiencies of the CsNEJs in both groups were measured 3 times and significant differences were determined using the student’s t-test." 2571 3891 W1996775489.pdf 1 15 separator 0.9970617 ¶ 3891 3893 W1996775489.pdf 1 16 title 0.9889024 "3. Gallbladder contraction in response to cholecystokinin by cholescintigraphy" 3893 3974 W1996775489.pdf 1 17 separator 0.9944242 ¶ 3974 3976 W1996775489.pdf 1 18 text 0.999556 "Rabbits (New Zealand White, male, 2.2–2.5 kg) were purchased from Samtako Bio Korea Inc. (Osan, Korea). Rabbits were cared for and handled according to guidelines issued by Chung-Ang University College of Medicine Animal Facility (an accreditedfacility) in accordance with AAALAC International Animal Carepolicy. Animal experiments were approved by the institutionalreview board of the Chung-Ang University animal facility (CAUMD 09-0024)." 3976 4424 W1996775489.pdf 1 19 separator 0.95105684 ¶ 4424 4426 W1996775489.pdf 1 20 text 0.9996012 "Gallbladder contraction and emptying time induced by cholecystokinin-8 (CCK–8) varied from rabbit to rabbit. To selectrabbits that responded sensitively to CCK-8, cholescintigraphy and 99mTc-mebrofenin (3-bromo-2,4,6-trimethylphenyl carba- moylmethyl iminodiacetic acid) were used. Briefly, rabbits werefasted for 12 hrs and anesthetized with a 0.47 mg/kg Rompun(xylazine hydrochloride; Bayer Korea, Seoul, Korea) and 12.5 mg/kg Zoletil 50 (Zolazepam and Tiletamine; Virvac Korea, Seoul), intramuscular injection." 4426 4952 W1996775489.pdf 1 21 separator 0.847278 ¶ 4952 4954 W1996775489.pdf 1 22 text 0.99945176 "99mTc-mebrofenin (74 MBq) in 0.5 ml volume was then administered via an ear vein to eachanesthetized rabbit. When full of 99mTc-mebrofenin, gallbladders were stimulated to contract by injecting CCK–8 intravenously at 20 ng/kg every 1 min. A dynamic image was taken every 1 min for 1 hour for each rabbit. All images were obtained with arotating dual-headed gamma camera equipped with a low-energy,high-resolution collimator (Vertex TM, Philips Healthcare, Cleve-land, OH, USA) using a 256 6256-pixel matrix at an energy range of 20% at 140 keV." 4954 5511 W1996775489.pdf 1 23 separator 0.9969252 ¶ 5511 5513 W1996775489.pdf 1 24 title 0.9878736 "4.In vivo imaging of migration of the CsNEJs using PET- CT" 5513 5574 W1996775489.pdf 1 25 separator 0.9957551 ¶ 5574 5576 W1996775489.pdf 1 26 text 0.9991901 "Fresh CsNEJs (n = ,3,000) were radio-labeled with18F-FDG by incubating them in a maintaining medium containing 74 MBq18F- FDG at 37 uC for 15 min. CsNEJs were washed 3 times with 1 6" 5576 5763 W1996775489.pdf 1 27 title 0.76091284 Author Summary 5763 5777 W1996775489.pdf 1 28 separator 0.9966638 ¶ 5777 5779 W1996775489.pdf 1 29 text 0.99675304 "Clonorchis sinensis adults habituating in the bile duct cause clonorchiasis endemic in East Asian countries, in which about 15–20 million people are supposedly infected. It has previously been reported that C. sinensis metacercariae excyst in the duodenum and that the juvenile flukesmigrate to the bile duct through the ampulla of Vater in 4– 7 hours. Recently advanced imaging technologies have enabled visualization of movements and localizations ofparasites in mammalian hosts. From present study, wefound the following: newly excysted C. sinensis juveniles (CsNEJs) were efficiently in vitro radiolabeled with 18F-FDG since CsNEJs have glucose transporters; CCK-8-induced gallbladder contraction was various rabbit to rabbit; CsNEJs promptly recognized bile and migrated up the duodenum to reach the intrahepatic bile ducts by way ofthe ampulla of Vater and the common bile duct as early as7–9 minutes after inoculation. Some CsNEJs responding slowly to the bile delayed arriving at the distal bile capillaries. It was visualized for the first time that theCsNEJs migrate quickly within 10–20 minutes from the duodenum to the intrahepatic bile duct. These findings provide fundamental information on the migration of parasites living in the biliary passages of mammals.In Vivo Migration of Clonorchis sinensis" 5779 7128 W1996775489.pdf 1 30 separator 0.7339153 ¶ 7128 7130 W1996775489.pdf 1 31 paratext 0.9842127 www.plosntds.org 2 December 2011 | Volume 5 | Issue 12 | e1414 7130 7193 W1996775489.pdf 1 0 paratext 0.9873007 Page 19/27 0 10 W4283258181.pdf 18 1 title 0.45844713 p 10 11 W4283258181.pdf 18 2 table 0.72486234 JS297 Δ pJS287 BamHI in-frame deletion This study 11 60 W4283258181.pdf 18 3 separator 0.947448 ¶ 60 62 W4283258181.pdf 18 4 table 0.7948622 pJS302 Δ pKanMobSacB::cytC4 in-frame deletion This study 62 119 W4283258181.pdf 18 5 separator 0.77678275 ¶ 119 121 W4283258181.pdf 18 6 table 0.799118 pJS314 Δ pBluescript::pufC in-frame deletion This study 121 177 W4283258181.pdf 18 7 separator 0.8047339 ¶ 177 179 W4283258181.pdf 18 8 table 0.74650824 pJS315 Δ pKanMobSacB::pufC in-frame deletion 179 224 W4283258181.pdf 18 9 separator 0.9905388 ¶ ¶ 226 232 W4283258181.pdf 18 10 title 0.9633904 Table 2 232 240 W4283258181.pdf 18 11 separator 0.9924923 ¶ 240 242 W4283258181.pdf 18 12 title 0.8315226 Oligonucleotide Primer Sequences 243 276 W4283258181.pdf 18 0 paratext 0.95870763 https://ncats.nih.gov/tox21 0 27 W3097280976.pdf 21 1 separator 0.9933491 ¶ 27 29 W3097280976.pdf 21 2 paratext 0.51627254 Tox21 29 35 W3097280976.pdf 21 3 title 0.6876657 :NCATS Public Data Release 35 61 W3097280976.pdf 21 0 paratext 0.9719782 229 0 3 W4390467522.pdf 2 1 separator 0.9872345 ¶ 3 5 W4390467522.pdf 2 2 title 0.9089137 Ramayana and Animism in Wayang Puppet Theatreand 5 55 W4390467522.pdf 2 3 text 0.9971514 "Christians, wayang plays present essentially an «animist ontology», braiding enter - tainment and ritual efficacy.4 Performances are occasioned by communal celebrations and rites of passages such as planting and harvest festivities, commemoration of ancestors, tooth filings, circumcisions, weddings, birthdays, thanksgiving for fishing, exorcism, completion of building projects, release from vows, pregnancy rites, and rites honoring the first time a baby sets foot on the ground or has a haircut. Performances aim to propi - tiate spirits, venerate ancestors, retell myths and legends, visualize the demonic and the di - vine, and remind audiences of their ethical duties, behavioral norms, and spiritual values." 55 790 W4390467522.pdf 2 4 separator 0.96551514 ¶ 791 793 W4390467522.pdf 2 5 text 0.99960315 "As vehicles for summoning unseen forces, the puppets themselves are sacred. The puppet, as what performance theorist Joe Roach calls an «effigy», summons through a process of «surrogation» historical or mythical figures at a remove. The kayon , a tree of life figure that opens and closes performances and acts as an all-purpose stage property, is an axis mundi , a representation of passage from the chthonic and demonic domain, through the middle world of humans, up to the celestial plane." 793 1301 W4390467522.pdf 2 6 separator 0.9589019 ¶ 1301 1303 W4390467522.pdf 2 7 text 0.9993515 "This does not imply that performing wayang should be equated with the worship of nature spirits. These beings – such as Dewi Sri, the rice goddess – do appear in wayang plays, but they are generally not revered as deities.5 Rather, for many Javanese Muslim puppeteers, for example, they are invoked as natural symbols in the service of collective well-being. As one senior puppeteer explained it to me, the ritual drama of Mapag Sri (‘Greeting Sri’) which concerns the rice goddess Sri and the origins of agriculture, spon - sored annually by agricultural villages in the Cirebon region of W est Java, is a collective search for «goodness, a search for purity, a search for God’s blessings. For mapag means ‘to follow’, while sri is ‘purity’. So with Mapag Sri the symbolic goal is for us, as God’s creations, to strive for goodness, for peace, for happiness, for salvation».6" 1303 2210 W4390467522.pdf 2 8 separator 0.9668939 ¶ 2210 2212 W4390467522.pdf 2 9 text 0.99949193 "But in wayang mythology, Sri is not only a symbol for the good, she is also a par - ticular kind of being, a dewi or bathari, who in wayang enters into dialogue with other" 2212 2389 W4390467522.pdf 2 10 separator 0.9791504 ¶ 2390 2392 W4390467522.pdf 2 11 bibliography 0.9856449 4 Cfr. D escola 2013: 129-143. 2392 2425 W4390467522.pdf 2 12 separator 0.99251246 ¶ 2425 2427 W4390467522.pdf 2 13 bibliography 0.50754553 5 Even in Bali, 2427 2444 W4390467522.pdf 2 14 text 0.48843178 2444 2445 W4390467522.pdf 2 15 bibliography 0.57599443 a majority Hindu island, the gods and nature spirits are prone to faults. 2445 2518 W4390467522.pdf 2 16 separator 0.99443305 ¶ 2518 2520 W4390467522.pdf 2 17 bibliography 0.54735506 6 Interview 2520 2533 W4390467522.pdf 2 18 caption 0.41043812 with 2533 2538 W4390467522.pdf 2 19 bibliography 0.4114824 Sukarta 2538 2546 W4390467522.pdf 2 20 caption 0.5293612 at 2546 2549 W4390467522.pdf 2 21 bibliography 0.39493313 his 2549 2553 W4390467522.pdf 2 22 caption 0.4385901 home in 2553 2561 W4390467522.pdf 2 23 bibliography 0.43424988 Bong 2561 2566 W4390467522.pdf 2 24 text 0.4000263 as 2566 2568 W4390467522.pdf 2 25 caption 0.37974533 , 2568 2569 W4390467522.pdf 2 26 bibliography 0.49222475 Majalengka on 25 June 2019: « 2569 2599 W4390467522.pdf 2 27 text 0.9957176 "kebecikan, nggayuh kealusan, nggayuh ridhoeng Pengeran. Mapag – nusul, Sri iku alus. Dados Mapag Sri ku tujuane sih dados, ‘ayulah, kula sageda makhlukeng Pangeran, ayo nggayuh kebecikan, mamrih keslametan, mamrih kebegjan, mamrih kerahyuan,’ simbolnya seperti itu »." 2599 2875 W4390467522.pdf 2 0 paratext 0.97775 "Journal of Law, Policy and Globalization www.iiste.org ISSN 2224-3240 (Paper) ISSN 2224-3259 (Online) Vol.115, 2021 ¶ 93" 0 271 W4206485376.pdf 2 1 separator 0.9808836 ¶ 272 274 W4206485376.pdf 2 2 text 0.5133361 based on availability charge or user-by- 274 315 W4206485376.pdf 2 3 bibliography 0.431991 charge 315 321 W4206485376.pdf 2 4 text 0.36556852 usag 321 326 W4206485376.pdf 2 5 bibliography 0.31720853 326 327 W4206485376.pdf 2 6 text 0.37198272 e 327 328 W4206485376.pdf 2 7 bibliography 0.3904346 charge 328 335 W4206485376.pdf 2 8 text 0.4211306 . The scheme of payment system is based on the ¶ 335 384 W4206485376.pdf 2 9 bibliography 0.36663792 384 385 W4206485376.pdf 2 10 text 0.33864936 agreement 385 394 W4206485376.pdf 2 11 bibliography 0.35332498 394 395 W4206485376.pdf 2 12 text 0.38652322 between the government and the private se ctors. 395 443 W4206485376.pdf 2 13 separator 0.99251854 ¶ ¶ 445 451 W4206485376.pdf 2 14 title 0.9917229 3. Characteristics of PPPs 451 479 W4206485376.pdf 2 15 separator 0.9961686 ¶ 480 482 W4206485376.pdf 2 16 text 0.9916636 "The provisions of infrastructures are identified as a state action in providing public facilities. Tra ditionally, the government carries out this provision. The governme nt, currently, do not dominate infrastructure devel opment. The private sectors involve in the development and operationalization of facilities for the community. This PPPs model is very different from the more dom inant models so far such as the traditional procurement and privatization." 482 958 W4206485376.pdf 2 17 separator 0.6658857 ¶ 960 962 W4206485376.pdf 2 18 text 0.99030477 "The differences between PPPs and the traditional pr ocurement are as follows. The legal relationship between the government and the private sectors in t raditional procurement is limited to the implementa tion of the design and construction of infrastructure that is g overned by a design-build (DB) agreement. 1 Private sectors build and the government finance and operate the in frastructure facilities. This is different from the PPPs model that private sectors carry out activities of Design -Build-Finance-Operate-Maintain (DBFOM) of faciliti es. The facilities will be returned to the government withi n a certain time frame as stipulated in the agreeme nt." 962 1642 W4206485376.pdf 2 19 separator 0.8452052 ¶ 1643 1645 W4206485376.pdf 2 20 text 0.9749049 "PPPs also differs from privatization. Based on the Indonesian law, the concept of privatization is kno wn as transfers of assets or equities from the state-owne d enterprises (SoE) to the private sectors. 2 The definition of privatization can be found in the Law No. 19 of 200 3 concerning State Owned Enterprise (hereinafter abbreviated as ‘Law of SoE’). In Article 1 Point 12 affirms that privatization as a result of the sale of shares of SoE either partially or wholly to the private party . The objective of privatization is to improve the performance or value of the company, increase benefits for the state and society, and share ownership to public." 1645 2320 W4206485376.pdf 2 21 separator 0.9726138 ¶ 2321 2323 W4206485376.pdf 2 22 text 0.99910235 "Privatization as a transfer of assets is regulated in the Law No. 1/2004 concerning State Treasury and the Government Regulation No. 27 of 2014 concerning The Management of State/Local Property as the implementing regulation. This Government Regulation stipulates that the transfer of properties owned b y state or regional government is classified privatization. Th e properties include the properties purchased or ob tained at the expense of state or regional budgets and other lega lly obtained from grants or the like, properties ob tained as execution of agreements, properties obtained in acc ordance with the provisions of statutory regulation s, or properties obtained under a court decision which ha s permanent legal force. In the PPPs scheme, there is no action of transferring asset or equities from state to private sectors." 2323 3186 W4206485376.pdf 2 23 separator 0.98504716 ¶ ¶ 3188 3194 W4206485376.pdf 2 24 title 0.9932653 4. Indonesian PPPs Laws 3194 3219 W4206485376.pdf 2 25 separator 0.99631506 ¶ 3220 3222 W4206485376.pdf 2 26 text 0.99862397 "The initial enactment of the Indonesian PPPs law wa s the Presidential Decree No. 7 of 1998 concerning Public- Private Partnerships in Development and/or Infrastr ucture Management (hereinafter referred to as 'Pres idential Decree 7/1998') in 1998. The Presidential Decree 7/ 1998 was declared null and void by the enactment of the Presidential Regulation No. 67 of 2005 concerning G overnment Cooperation with Business Entities in the Provision of Infrastructure (hereinafter abbreviate d as ‘Presidential Regulation 67/2005’). This Presi dential Regulation was substituted by Presidential Regulati on No. 38 of 2015 concerning Government Cooperation with Business Entities in the Provision of Infrastructur e (hereinafter abbreviated ‘Presidential Regulation 38/2015’)." 3222 4015 W4206485376.pdf 2 27 separator 0.96915543 ¶ 4016 4018 W4206485376.pdf 2 28 text 0.99934417 "Presidential Decree 7/1998 only regulated the devel opment of economic infrastructures. The social infrastructures have not been regulated in the Pres idential Decree until the enactment of Presidential Regulation 67/2005. Economic and social infrastructures remain as part of Presidential Regulation 38/2015." 4018 4336 W4206485376.pdf 2 29 separator 0.98438525 ¶ 4337 4339 W4206485376.pdf 2 30 text 0.9971776 "Presidential Regulation 38/2015 affirms five object ives of the PPPs. 3 Firstly, PPPs aim to provide for sustainable financing in the provision of infrastru cture through the mobilization of private funds. Se condly, PPPs aims to realisation the provision of infrastructure s with certain quality, effective, efficient, targe ted, and timely. Thirdly, PPPs is endeavoured to encourage the parti cipation of private sector in the provision of infr astructures based on sound business principles. Fourthly, PPPs encourages the use of the principle of users pay fo r services received, or in some cases consider the ability to pay users. Fifthly, PPPs provides certainty of retu rn of investment of private sector in the provision of in frastructures through payment mechanism periodicall y by government to private sector." 4339 5181 W4206485376.pdf 2 31 separator 0.94082165 ¶ 5182 5184 W4206485376.pdf 2 32 text 0.9866611 "The principles of PPPs adopted by the Presidential Regulation 38/2015 are as follows. 4 Firstly, the principle of partnerships is the cooperation between the gove rnment and the private sector based on the legislat ion and considers the needs of both parties. Secondly, the principle of utilization is the provision of infras tructure by the government and private sector to provide social and economic benefits for the community. Thirdly, the fair competition principle is the procurement of busines s entity conducted through fair, open, and transpar ent." 5184 5755 W4206485376.pdf 2 33 separator 0.9792856 ¶ ¶ 5756 5762 W4206485376.pdf 2 34 bibliography 0.9968268 "1 Grimsey, Darrin and Mervyn Lewis (2007) Public Private Partnerships and Public Procurement , Agenda, Volume 14, Number 2, pp. 171- 188" 5762 5901 W4206485376.pdf 2 35 separator 0.9021385 ¶ 5902 5904 W4206485376.pdf 2 36 bibliography 0.9970475 2 Yescombe, E. R. (2007) Public-Private Partnership , Elsevier, Great Britain 5904 5982 W4206485376.pdf 2 37 separator 0.98901045 ¶ 5983 5985 W4206485376.pdf 2 38 title 0.9267783 3 Article 3 the Presidential Regulation 38/2015 5985 6033 W4206485376.pdf 2 39 separator 0.9927482 ¶ 6034 6036 W4206485376.pdf 2 40 paratext 0.58901185 4 6036 6038 W4206485376.pdf 2 41 title 0.3903037 Article 6038 6046 W4206485376.pdf 2 42 paratext 0.4468047 4 6046 6048 W4206485376.pdf 2 43 title 0.382997 the Presidential Regulation 6048 6076 W4206485376.pdf 2 44 paratext 0.431239 38/2015 6076 6084 W4206485376.pdf 2 0 paratext 0.593335 4 ClinicalandDevelopmentalImmunology 0 36 W2147638580.pdf 3 1 separator 0.9672878 ¶ 36 38 W2147638580.pdf 3 2 title 0.95962316 "Table 2: Effects of KIRgenesandgenotypesontheonsetageofHCC byKManalysis." 38 113 W2147638580.pdf 3 3 separator 0.94517374 ¶ 113 115 W2147638580.pdf 3 4 table 0.9965928 "KIRgeneand genotypen(%) Medianage Pvalue 2DL1Negative 4(2.3) 450.82 Positive 167(97.7) 50 2DL2Negative 137(80.1) 500.09 Positive 34(19.9)) 49 2DL3Negative 4(2.3) 450.81 Positive 167(97.7)) 50 2DL5Negative 103(60.2) 500.67 Positive 68(39.8) 50 3DL1Negative 3(1.8) 410.68 Positive 168(98.2) 50 2DS1Negative 109 (63.7) 500.49 Positive 62(36.3) 49 2DS2Negative 139 (81.3) 500.09 Positive 32(18.7) 50 2DS3Negative 145(84.8) 500.07 Positive 26(15.2) 49 2DS4(f)Negative 28(16.4) 490.83 Positive 143(83.6) 50 2DS4(d)Negative 116(67.8) 500.97 Positive 55(32.2) 49 2DS5Negative 124 (72.5) 500.50 Positive 47 (27.5) 51 3DS1Negative 108 (63.2) 490.98 Positive 63(36.8) 50 KIRgenotypeAA 84(49.1) 500.42 BX 87(50.9) 50" 115 874 W2147638580.pdf 3 5 separator 0.98395205 ¶ 874 876 W2147638580.pdf 3 6 text 0.998956 "thisperiodicscreeninghasbeenpracticedwidely,itsbenefits remain uncertain. Therefore, an optimal HCC surveillanceprogramwithacceptablecosteffectivenessisneeded,partic-ularlyforat-riskpopulations[ 4,29].Oneofthecontroversial issues is that when to begin this periodic screening in HBV-infected patients. The American Association for Study ofLiver Disease recommends that, for noncirrhotic patientswithhepatitisB,malesabovetheageof40yearsandfemalesabovetheageof50yearsareappropriatecandidatesforHCC surveillance [ 30]. The Asia-Pacific Association for Study of Liver Disease recommends the HCC surveillance programfor high-risk patients with chronic hepatitis B (especiallythose who aged>30yearswithserumHBVDNAlevels >20 000IU/mL)intheabsenceofaknowndiagnosisofcirrhosis[5].TheMinistryofHealthofthePeople’sRepublicofChina recommends lately that, for HBV-infected patients, malesabove the age of 40 years and females above the age of 50years are appropriate candidates for HCC surveillance [ 28]." 876 1881 W2147638580.pdf 3 7 separator 0.98415196 ¶ 1881 1883 W2147638580.pdf 3 8 text 0.9984397 K n o w l e d g eo nt h ef a c t o r st h a ti n fl u e n c et h ea g eo fH C Conset will provide basis for the improvement of the currentHCC surveillance programs. HCC occurs mainly in men.Male:femaleratiosbetween3:1and4:1arereportedinEast 1883 2124 W2147638580.pdf 3 9 title 0.98188937 "Table 3: Effects of HLA-C-KIR ligand-receptorcombinationsonthe onsetageofHCCbyKManalysis." 2124 2215 W2147638580.pdf 3 10 separator 0.9829862 ¶ 2215 2217 W2147638580.pdf 3 11 table 0.99588084 "HLA-KIR combinationnMedianage Pvalue C1C1-KIR2DL3Negative 40 500.81 Positive 98 47 C1C2-KIR2DL3Negative 109 480.78 Positive 29 50 C1C2-KIR2DL1Negative 110 490.65 Positive 28 50 C2C2-KIR2DL1Negative 131 490.81 Positive 7 50 C1C1-KIR2DS2/2DL2Negative 141 500.004∗∗ Positive 20 44 C1C2-KIR2DS2/2DL2Negative 155 490.53 Positive 8 53 C1C2-KIR2DS1Negative 134 500.68 Positive 7 50 C2C2-KIR2DS1Negative 138 500.12 Positive 3 43 ∗∗P<0.01." 2217 2682 W2147638580.pdf 3 12 separator 0.99427915 ¶ 2682 2684 W2147638580.pdf 3 13 title 0.87611675 "Table 4: Multivariate Cox model survival analysis of C1C1+2DS2/2DL2 andotherfactorsontheonsetageofHCC." 2684 2789 W2147638580.pdf 3 14 separator 0.9328582 ¶ 2789 2791 W2147638580.pdf 3 15 table 0.99330974 "Factor Pvalue HR 95%CI C1C1+2DS2/2DL2 0.04∗1.70 1.01–2.85 Cirrhosis 0.03 0.59 0.36–0.96HBeAgpositive 0.39 1.19 0.80–1.77 FamilyhistoryofHBV-relateddiseases 0.23 1.30 0.85–2.01 ∗P<0.05." 2791 2984 W2147638580.pdf 3 16 separator 0.9916477 ¶ 2984 2986 W2147638580.pdf 3 17 text 0.99915504 "China[1,20,27].Inthisstudy,weexaminedthe KIRandHLA genetic background in 171 male patients. We found that themedianonsetageofHCCwas6yearsearlierinpatientswithap a r t i c u l a r HLA-KIR combination of C1C1-KIR2DS2/2DL2 thanthat ofthepatientswithoutthiscombination( Table 4)." 2986 3266 W2147638580.pdf 3 18 separator 0.90698284 ¶ 3266 3268 W2147638580.pdf 3 19 text 0.9988926 "The patients with C1C1-KIR2DS2/2DL2 accounted for about 12% of this study cohort. Because both KIRgenes and HLA- C1can be identified by real-time polymerase chain reaction [31], which is economical and time saving, the detection ofKIR2DS2/2DL2 andHLA-C1 is easy to be applied in clinicalpractice.Therefore,thisstudycouldhelpfocusearly- detection programs to a two-tiered model for greatest cost- benefitratio." 3268 3692 W2147638580.pdf 3 20 separator 0.9765942 ¶ 3692 3694 W2147638580.pdf 3 21 text 0.9993352 "In our previous case-control study, several KIRand HLAvariants, including HLA-C1C1 ,HLA-Bw4-80I, and KIR2DS4(f)/(d) , were identified as the risk factors for HCC developmentinthepatientswithHBVinfection.Becauseallof these risk factors we found had been reported to result inhighNKcellfunctionalpotential,thedatastronglysuggestedthat overactivation of NK cell contributed to HBV-relatedHCCdevelopment[ 20].Theresultsofcurrentstudysupport the importance of NK cells (or other KIR expressing cells)intheprogressofHBV-relatedHCCdevelopment.Wecouldnotdistinguishtheeffectbetween C1C1-2DS2 andC1C1-2DL2" 3694 4299 W2147638580.pdf 3 0 text 0.9931965 "Q8 showed signi ficant differences for both virtual robotic limb appearances ( Figures 11A, B , and Supplementary Table S1 )." 0 126 W4388456642.pdf 12 1 separator 0.9864367 ¶ 126 128 W4388456642.pdf 12 2 text 0.9973371 "Q1 scores were signi ficantly higher in the hand condition compared to the foot and multiple body parts conditions. Q2 and Q7 scores were signi ficantly higher in the hand condition compared to the foot and multiple body partsconditions. In addition, these scores were signi ficantly lower in the foot condition than in the multiple body parts condition.Q3 scores were signi ficantly higher in the hand condition than in the conditions of the foot and multiple body parts. Furthermore,these scores were signi ficantly higher in the foot condition than in the multiple body parts cond ition. Q8 scores were signi ficantly l o w e ri nt h eh a n dc o n d i t i o nt h a ni nt h ef o o ta n dm u l t i p l eb o d y parts conditions in the manipulator appearance condition, andQ6 scores were signi ficantly higher in the hand condition than in the foot condition. Furthermore, Figures 11C, D show differences in the subjective sense of agency and body ownership between thehuman avatar appearance and the multiple body parts condition.Q2 and Q7 scores for the hand in the human avatar appearancewere signi ficantly higher compared to the virtual robotic limb in the multiple body parts condition. These scores for the foot in the h u m a na v a t a ra p p e a r a n c ew e r es i g n i ficantly lower compared to the virtual robotic limb in the multiple body parts condition." 128 1517 W4388456642.pdf 12 3 separator 0.98450637 ¶ 1517 1519 W4388456642.pdf 12 4 text 0.9994005 "Q3 and Q8 scores for the hand of the human avatar appearancewere signi ficantly lower than in the virtual robotic limb of the multiple body parts condition. These scores for the foot in thehuman avatar were signi ficantly higher than those of the virtual robotic limb in the multiple body parts condition. Q4 scores forthe human avatar hand appearance were signi ficantly lower than those in the multiple body parts condition of the manipulatorappearance. Q6 scores for the human avatar hand appearancewere signi fic a n t l yh i g h e rt h a nt h o s ef o rt h em u l t i p l eb o d yp a r t s condition. Q9 scores for the human avatar ’s hand appearance were signi ficantly lower than those fo r the multiple body parts condition." 1519 2259 W4388456642.pdf 12 5 separator 0.97603595 ¶ 2259 2261 W4388456642.pdf 12 6 text 0.9993056 "Q2 and Q3 scores in the multiple body parts condition were signi ficantly correlated with those in the manipulator appearance condition ( p= .035, r= .433, R 2= .277) ( Figure 12B ). Q7 and Q8 scores in the multiple body parts condition were signi ficantly correlated with those in the humanoid condition ( p= .017, r= .482, R2= .218) ( Figure 12C ) and the manipulator appearance condition ( p<.001, r= .838, R2= .691) ( Figure 12D ). There was no signi ficant correlation between the questionnaire scores for each body part (hand: Q2, Q7, foot: Q3, Q8) and eachproprioceptive drift in the multiple body parts condition(Table 2 )." 2261 2908 W4388456642.pdf 12 7 separator 0.9965385 ¶ 2908 2910 W4388456642.pdf 12 8 title 0.9866204 6 Discussion 2910 2923 W4388456642.pdf 12 9 separator 0.99368846 ¶ 2923 2925 W4388456642.pdf 12 10 title 0.9845015 "6.1 Gap between proprioceptive drift and subjective perceptual attribution" 2925 3002 W4388456642.pdf 12 11 separator 0.9866042 ¶ 3002 3004 W4388456642.pdf 12 12 text 0.9980313 "Each measurement index in this study showed a pattern of perceptual attribution in each condition ( Figure 13 ). However, the results of proprioceptive drift and subjective perceptual" 3004 3192 W4388456642.pdf 12 13 caption 0.91034025 FIGURE 13 3192 3201 W4388456642.pdf 12 14 separator 0.76175034 ¶ 3201 3203 W4388456642.pdf 12 15 caption 0.71961516 Main results of this study. Each cell shows 3203 3247 W4388456642.pdf 12 16 text 0.60662764 the main findings based on each index 3247 3284 W4388456642.pdf 12 17 caption 0.6064019 . 3284 3285 W4388456642.pdf 12 18 separator 0.9929224 ¶ 3285 3287 W4388456642.pdf 12 19 table 0.95366013 "TABLE 2 Correlation between proprioceptive drift and questionnaire for each body part. Questionnaire Proprioceptive drift Visual appearance pr R2 Q2 Hand Humanoid .983 −.005 .001 Q2 Hand Manipulator .584 .128 .014 Q3 Foot Humanoid .478 −.152 .018 Q3 Foot Manipulator .206 .333 .072Q7 Hand Humanoid .113 .332 .088 Q7 Hand Manipulator .445 .230 .027 Q8 Foot Humanoid .099 .345 .154Q8 Foot Manipulator .450 .138 .026" 3287 3715 W4388456642.pdf 12 20 separator 0.9628191 ¶ 3715 3717 W4388456642.pdf 12 21 paratext 0.98174447 Frontiers in Virtual Reality frontiersin.org 13Sakurada et al. 10.3389/frvir.2023.1210303 3717 3807 W4388456642.pdf 12 0 separator 0.62581784 1 2 W1489269437.pdf 29 1 paratext 0.9151754 "¶ Computational Fluid Dynamics Technologies and Applications 210" 1 69 W1489269437.pdf 29 2 separator 0.99344534 ¶ 70 72 W1489269437.pdf 29 3 text 0.98867077 "The simulations produced the following conclusions: 1. After calibration, the SST k- ω model simulated the velocity recovery rate observed downwind from a 2-dimensio nal windbreak with an R2 factor of 0.95 for distances of 0 to 30 H, where H is the height of the windbreak; 2. The SST k- ω model predicted odour concentration with an R2 value generally above 0.75 for values over 150 m away from the windbreak, which is considered quite acceptable for odour simulations. 3. A less porous or denser windbreak (aerodynam ic porosity of 0.2 versus 0.4 and 0.66) produced a shorter, wider and more intense odour plume; 4. Assuming that the air flow resistance was proportional to the square of the tree diameter, the tree type had almost no effect on the size of the odour plume. As opposed to the conifer, the poplar windbreak created a slightly shorter odour plume for the same aerodynamic porosity; 5. A taller windbreak resulted in a shorter odour plume, by creating a taller low turbulence zone downwind from the windbr eak, where more odours were trapped and retained for dispersion; 6. When close to odour source, the windbr eak produces a shorter odour plume. " 72 1292 W1489269437.pdf 29 4 separator 0.49047598 ¶ 1292 1293 W1489269437.pdf 29 5 text 0.99686897 "7. In terms of climatic factors, atmospheric stability was the governing element since it generally establishes wind speed and air te mperature gradient; under low wind speeds weaker than convective forces, the odour plume was shorter but under low convective forces, higher wind speeds created more turbulences and shorter odour plumes." 1293 1641 W1489269437.pdf 29 6 separator 0.9968164 ¶ 1643 1645 W1489269437.pdf 29 7 title 0.99037313 6. Nomenclature 1645 1661 W1489269437.pdf 29 8 separator 0.9952388 ¶ 1662 1664 W1489269437.pdf 29 9 text 0.78986377 "AHT is absolute hedonic tone AS is atmospheric stability as is a factor involved in determining TKE" 1664 1770 W1489269437.pdf 29 10 table 0.5551049 ¶ Cir 1771 1777 W1489269437.pdf 29 11 text 0.5047786 is the in 1777 1787 W1489269437.pdf 29 12 table 0.5295102 er 1787 1789 W1489269437.pdf 29 13 text 0.5327956 tial resistance 1789 1804 W1489269437.pdf 29 14 table 0.59629995 "coefficient Cir" 1804 1823 W1489269437.pdf 29 15 text 0.59473944 0 is the constant 1823 1840 W1489269437.pdf 29 16 table 0.57029676 ¶ Cp 1841 1846 W1489269437.pdf 29 17 text 0.564495 is specific heat of air 1846 1870 W1489269437.pdf 29 18 table 0.60428596 ¶ D1 and D 1871 1882 W1489269437.pdf 29 19 text 0.5412458 2 1882 1883 W1489269437.pdf 29 20 table 0.5054793 are 1883 1887 W1489269437.pdf 29 21 text 0.5907013 the tree 1887 1897 W1489269437.pdf 29 22 table 0.51576054 diameter 1897 1905 W1489269437.pdf 29 23 text 0.5041279 s 1905 1906 W1489269437.pdf 29 24 table 0.6025488 ¶ Di 1907 1912 W1489269437.pdf 29 25 text 0.5022252 , 1912 1913 W1489269437.pdf 29 26 table 0.5779147 "m is the diffusion coefficient for species i in the gaseous mixture DT,i is the thermal diffusion coefficient for species" 1913 2037 W1489269437.pdf 29 27 text 0.4937798 i 2037 2039 W1489269437.pdf 29 28 table 0.5639715 in 2039 2042 W1489269437.pdf 29 29 text 0.48368573 the 2042 2046 W1489269437.pdf 29 30 table 0.74424833 "gaseous mixture DWO is the distance between the windbreak and the odour source E is the total energy Fi is the resistance to wind flow g is acceleration of gravity gi" 2046 2230 W1489269437.pdf 29 31 text 0.5626537 is the component of the 2230 2254 W1489269437.pdf 29 32 table 0.5163819 gr 2254 2258 W1489269437.pdf 29 33 text 0.5208574 avitational vector 2258 2276 W1489269437.pdf 29 34 table 0.5908548 in 2276 2279 W1489269437.pdf 29 35 text 0.5063786 the 2279 2283 W1489269437.pdf 29 36 table 0.6847636 "ith direction H is the total height of the windbreak HF is the vertical heat flux ¶" 2283 2374 W1489269437.pdf 29 37 text 0.61342335 hi is the height at which the rate of the gr adient of the tree 2374 2439 W1489269437.pdf 29 38 table 0.5374949 diameter 2439 2447 W1489269437.pdf 29 39 text 0.5302598 changed at the ith 2447 2466 W1489269437.pdf 29 40 table 0.6380426 "height hABL is the height of the atmospheric boundary layer Hi is the " 2466 2543 W1489269437.pdf 29 41 text 0.4848302 sensible 2543 2551 W1489269437.pdf 29 42 table 0.6002331 "enthalpy of ith species HT is the odour hedonic tone Ji is" 2551 2616 W1489269437.pdf 29 43 text 0.49082947 the 2616 2621 W1489269437.pdf 29 44 table 0.5643752 diffusion flux of 2621 2638 W1489269437.pdf 29 45 text 0.53173375 2638 2639 W1489269437.pdf 29 46 table 0.50396717 species 2639 2646 W1489269437.pdf 29 47 text 0.51770145 2646 2647 W1489269437.pdf 29 48 table 0.50554925 i 2647 2648 W1489269437.pdf 29 49 text 0.7666727 ¶ ka is the van Karman constant ranging from 0.35 to 0.43, and n9ormally equal to 0.4 2649 2736 W1489269437.pdf 29 50 separator 0.9033857 ¶ 2737 2739 W1489269437.pdf 29 51 text 0.92158335 www.intechopen.com 2739 2758 W1489269437.pdf 29 0 text 0.9992702 "(SPRINT), aspirin use had no impact on the risk of all-cause death in hypertensive patients (HR: 0.84, 95% CI: 0.53 –1.30) ( Del et al., 2022 )." 0 146 W4320922682.pdf 7 1 separator 0.96579707 ¶ 146 148 W4320922682.pdf 7 2 text 0.99931914 "According to a cohort study using the Colorectal Cancer Data BaseSweden (CRCBaSe), aspirin use dur ing follow-up was linked to an increased risk of all-cause mortality (HR: 1.09, 95% CI: 1.04 –1.15) but not colorectal cancer (CRC) mortality (HR: 0.98, 95% CI: 0.91 –1.06) among patients who were diagnosed with CRC ( Shahrivar et al., 2022 )." 148 497 W4320922682.pdf 7 3 separator 0.98307335 ¶ 497 499 W4320922682.pdf 7 4 text 0.9996698 "In Denmark, after a prostate cancer diagnosis, the usage of low-dose aspirin was compared to death in a large cohort research. According tothefindings, taking low-dose aspirin during exposure periods of 5 years (HR: 0.91, 95% CI: 0.83 –1.00) and 7 years (HR: 0.84, 95% CI: 0.72 –0.97) was associated with a slight reduction in prostate cancer mortality(Skriver et al., 2019 ). The Nurses ’Health Study found that women who reported low-to-moderate aspirin use had a decreased risk of death from all causes (HR: 0.75, 95% CI: 0.71 –0.81), CVD (HR: 0.62, 95% CI: 0.55 –0.71), and cancer (HR: 0.88, 95% CI: 0.81 –0.96) during the course of a 24-year follow-up compared to those who never took aspirin ( Chan et al., 2007 )." 499 1235 W4320922682.pdf 7 5 separator 0.98577976 ¶ 1235 1237 W4320922682.pdf 7 6 text 0.99712163 "As previously mentioned, aspirin use and the risks of cardiovascular events, overall mortal ity, and cause-speci ficd e a t ha r es t i l lb e i n gd e b a t e d ." 1237 1402 W4320922682.pdf 7 7 separator 0.80914795 ¶ 1402 1404 W4320922682.pdf 7 8 text 0.99962455 "Previous RCTs and observational studies were mainly conducted inselected populations and there is a lack of studies conducted in community-based genera l populations. For the first time, our study provides a special perspective on aspirin ’s primary preventive effect in the generally representative nation al population. We found that taking low-dose aspirin had no bene ficial effect on the risk of dying due to any cause while high-dose aspirin use might increases the risk of CVDdeath, especially for those aged 60 years and older." 1404 1948 W4320922682.pdf 7 9 separator 0.97894585 ¶ 1948 1950 W4320922682.pdf 7 10 text 0.99972874 "Bleeding is the most frequent aspirin side effect, which may cancel out any positive effects. For example, taking aspirin increased gastrointestinal bleeding incidents substantially (HR: 2.11, 95% CI: 1.36 –3.28) compared with placebo in the ARRIVE trial ( Gaziano et al., 2018 ). An earlier study found that aspirin users who are 70 years of age or older have a dramatically increased risk ofbleeding events ( Patrono et al., 2005 ). Aspirin ’s positive and negative effects have the same underlying me chanism. The primary metabolite of arachidonic acid, thromboxane A2 (TXA2), can be inhibited byaspirin. Aspirin ’s therapeutic effectiveness in reducing the risk of atherothrombosis and its side effect of bleeding can be explained by the fact that TXA2 is a potent inducer of platelet aggregation ( Patrono, 2015;Petrucci et al., 2022 ). Controversial reco mmendations made by European and US guidelines re flect the uncertainty over the relative benefits and risks of using aspirin for the primary prevention of CVD." 1950 2994 W4320922682.pdf 7 11 separator 0.982189 ¶ 2994 2996 W4320922682.pdf 7 12 text 0.9997317 "Our study comes with a number of limitations. First, the usage of aspirin use was recorded only based a one-time questionnaire, whichmay lead to recall bias and inaccurate estimate of dose intensity. Second, although it is based on the fact that preventive drugs are generally taken regularly for a long time, the NHANES preventive aspirin use questionnaire did not collect participants ’drug duration, which should be taken into account when interpreting the results. Third,there is a lack of data on the incidence of CVD or bleeding events duringfollow-up because this analysis lin ked NHANES with death records of NDI Fourth, the observational study design makes it impossible toestablish a causal link between aspirin use and risk of death." 2996 3753 W4320922682.pdf 7 13 separator 0.9389939 ¶ 3753 3755 W4320922682.pdf 7 14 text 0.9994294 "In conclusion, using low-dose as pirin has no effect on the risk of death from any causes, whereas taking high dosage of aspirin useincreases the risk of CVD death, especially for those aged 60 years andolder." 3755 3967 W4320922682.pdf 7 15 title 0.98798597 Data availability statement 3967 3994 W4320922682.pdf 7 16 separator 0.99264556 ¶ 3994 3996 W4320922682.pdf 7 17 text 0.997179 "The raw data supporting the conclusion of this article will be made available by the authors, without undue reservation." 3996 4119 W4320922682.pdf 7 18 separator 0.9966396 ¶ 4119 4121 W4320922682.pdf 7 19 title 0.9884897 Ethics statement 4121 4138 W4320922682.pdf 7 20 separator 0.9942994 ¶ 4138 4140 W4320922682.pdf 7 21 text 0.9988842 "The studies involving human pa rticipants were reviewed and approved by The US National Center for Health Statistics(NCHS) institutional review boa rd. The patients/participants provided their written informed c onsent to participate in this study." 4140 4395 W4320922682.pdf 7 22 separator 0.9968264 ¶ 4395 4397 W4320922682.pdf 7 23 title 0.9830068 Author contributions 4397 4418 W4320922682.pdf 7 24 separator 0.99436814 ¶ 4418 4420 W4320922682.pdf 7 25 text 0.99416214 "LZ and GL contributed to the study conception and design. LZ and YC contributed to the material preparation, datacollection and analysis. The first draft of the manuscript was written by LZ, YC, and FC. JL, HH, and GL contributed to thereview and editing the manuscript. All authors read and approved the final manuscript." 4420 4747 W4320922682.pdf 7 26 separator 0.9964485 ¶ 4747 4749 W4320922682.pdf 7 27 title 0.98608637 Funding 4749 4757 W4320922682.pdf 7 28 separator 0.9941984 ¶ 4757 4759 W4320922682.pdf 7 29 text 0.9991247 "This study was funded by Excellent Doctoral Program of Sichuan Provincial People ’s Hospital and it was partially supported by National Natural Science Foundation of China (No. 81600259), Natural Science Foundation of Sichuan Province (No. 2022NSFSC0817; No. 2023NSFSC0590; No. 2022NSFSC0811; No.2022NSFSC1589), and Sichuan Cadre Health Research Project (No.Chuanganyan ZH 2022-201). The design, analysis, and writing ofthis publication were all independent of the funding source." 4759 5248 W4320922682.pdf 7 30 separator 0.9969045 ¶ 5248 5250 W4320922682.pdf 7 31 title 0.9832263 Acknowledgments 5250 5266 W4320922682.pdf 7 32 separator 0.9896363 ¶ 5266 5268 W4320922682.pdf 7 33 text 0.9978438 "We are grateful for the efforts and contributions made by all of the NHANES participants and staff." 5268 5370 W4320922682.pdf 7 34 separator 0.9963385 ¶ 5370 5372 W4320922682.pdf 7 35 title 0.9879538 Conflict of interest 5372 5392 W4320922682.pdf 7 36 separator 0.9891938 ¶ 5392 5394 W4320922682.pdf 7 37 text 0.99838406 "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential con flict of interest." 5394 5570 W4320922682.pdf 7 38 separator 0.995782 ¶ 5570 5572 W4320922682.pdf 7 39 title 0.9796325 Publisher ’s note 5572 5590 W4320922682.pdf 7 40 separator 0.9843082 ¶ 5590 5592 W4320922682.pdf 7 41 text 0.9923312 "All claims expressed in this article are solely those of the authors and do not necessarily represent those of their af filiated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, orclaim that may be made by its manufacturer, is not guaranteed orendorsed by the publisher." 5592 5943 W4320922682.pdf 7 42 separator 0.9914965 ¶ 5943 5945 W4320922682.pdf 7 43 paratext 0.87209123 Frontiers in Pharmacology frontiersin.org 08Chen et al. 10.3389/fphar.2023.1099810 5945 6028 W4320922682.pdf 7 0 paratext 0.7625269 "Ontologias e taxonomias: diferenças Luciane Paula Vital; Lí" 0 63 W2017988284.pdf 9 1 contact 0.4828912 gia 63 66 W2017988284.pdf 9 2 paratext 0.60644263 Maria Arruda Café 66 84 W2017988284.pdf 9 3 separator 0.7110307 ¶ ¶ 85 91 W2017988284.pdf 9 4 paratext 0.9257474 Perspectivas em Ciência da Informação, v.16, n.2, p .115-130, abr./jun. 2011 124 91 173 W2017988284.pdf 9 5 bibliography 0.4501509 hier 174 179 W2017988284.pdf 9 6 text 0.56743264 árquica. No entanto, em um ambiente 179 214 W2017988284.pdf 9 7 bibliography 0.55698794 corporativo 214 226 W2017988284.pdf 9 8 text 0.57650375 isso não 227 236 W2017988284.pdf 9 9 bibliography 0.8352269 236 237 W2017988284.pdf 9 10 text 0.74795276 é possível 237 247 W2017988284.pdf 9 11 bibliography 0.65459836 ¶ 248 250 W2017988284.pdf 9 12 text 0.5889401 nem 250 254 W2017988284.pdf 9 13 bibliography 0.5497258 desej 254 260 W2017988284.pdf 9 14 text 0.52092445 ável 260 264 W2017988284.pdf 9 15 bibliography 0.8326847 ” (WOODS, 2004, p. 3) 264 285 W2017988284.pdf 9 16 paratext 0.89171726 5. 285 288 W2017988284.pdf 9 17 title 0.50388485 Um documento 288 301 W2017988284.pdf 9 18 text 0.48905793 "pode ser de interesse de vários departamentos dentro da organiz" 301 368 W2017988284.pdf 9 19 title 0.46931463 ação 368 373 W2017988284.pdf 9 20 text 0.6461985 ", com implicações e objetivos diferentes e precisa estar representado dentro desses diversos interesses." 373 483 W2017988284.pdf 9 21 separator 0.99057984 ¶ 486 488 W2017988284.pdf 9 22 text 0.99192405 "Outros tipos de relação entre conceitos como as de funcionalidade também são importantes. A relação funcional é aquel a em que, segundo Dahlberg (1978a, p. 105) “Pode-se conhecer o caráte r semântico [...] tendo por base as chamadas valências semânticas dos verbos [...]”." 488 771 W2017988284.pdf 9 23 separator 0.6621649 ¶ 772 774 W2017988284.pdf 9 24 text 0.99742985 "Valência semântica é caracterizada como “a soma dos lugares a serem preenchidos de acordo com a ligação deste conceito com outros” (DALHBERG, 1978a, p. 105). As relações entre os con ceitos também podem ser intensionais, redes de conceitos, usadas tanto nas ontologias quanto nas taxonomias. Sendo que, nas taxonomias co rporativas, segundo Woods (2004) as relações necessitam ser fle xíveis, pragmáticas assim como coerentes." 774 1220 W2017988284.pdf 9 25 separator 0.98547363 ¶ 1221 1223 W2017988284.pdf 9 26 text 0.98482066 "De acordo com Holgate (2004), há quatro formas de s e construir uma taxonomia: a) adquirir uma taxonomia pré-definida; b) construir manualmente uma taxonomia; c) construir automaticamente uma taxonomia; e d) uma combinação de automática e manual (híbrida). ¶" 1223 1499 W2017988284.pdf 9 27 separator 0.6203313 ¶ 1501 1503 W2017988284.pdf 9 28 text 0.9984677 "Holgate (2004) afirma que a forma mais adequada dep ende de alguns critérios que variam em cada organização, co mo: a) o problema que a taxonomia está tendo que respon der; b) o tipo e o alcance da informação corporativa; c) o volume do conteúdo; e d) a disponibilidade dos especialistas da área para estarem desenvolvendo a taxonomia." 1503 1858 W2017988284.pdf 9 29 separator 0.9731875 ¶ 1859 1861 W2017988284.pdf 9 30 text 0.99336916 "Woods (2004) explica que, em ambientes organizacion ais, as taxonomias precisam: a) fazer parte de um processo de gestão do conhecim ento mais amplo; b) estar relacionadas com arquiteturas de administr ação da informação, como portais, datawarehousing, etc; e c) estar relacionadas a um ambiente de informações integrado, procurando entender o fluxo de informação e semânti co da organização. ¶ Na construção de taxonomias, alguns critérios devem ser observados: ¶ a)Comunicabilidade: termos utilizados devem transpa recer os conceitos carregados de acordo com a linguagem util izada" 1861 2483 W2017988284.pdf 9 31 separator 0.7327405 "¶ 5" 2484 2550 W2017988284.pdf 9 32 bibliography 0.9513407 "“A classical taxonomy assumes that each element can only belong to one branch of the hierarquical tree. However, in a corporate environm ent, such formal ordering is neither feasible nor desirable” (WOODS, 2004, p. 3)." 2550 2776 W2017988284.pdf 9 0 paratext 0.9632112 67 0 2 W2466046010.pdf 9 1 separator 0.7075058 ¶ 2 4 W2466046010.pdf 9 2 paratext 0.9202584 Estudos de Psicologia, 21(1), janeiro a março de 2016, 58-68Regul 4 70 W2466046010.pdf 9 3 title 0.7195232 ação emocional, bem-estar psicológico 70 107 W2466046010.pdf 9 4 bibliography 0.98763585 "e bem-estar subjetivoHolland, K. D., & Holahan, C. K. (2003). The relation of social support and coping to positive adaptation to breast cancer. Psychology and Health , 18(1), 15-29. doi: 10.1080/0887044031000080656" 107 329 W2466046010.pdf 9 5 separator 0.95264393 ¶ 329 331 W2466046010.pdf 9 6 bibliography 0.9980442 "Hu, L. T., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struc - tural Equation Modeling , 6, 1-55. doi: 10.1080/10705519909540118" 331 559 W2466046010.pdf 9 7 separator 0.956119 ¶ 559 561 W2466046010.pdf 9 8 bibliography 0.9980745 "Keyes, C. L. M., Shmotkin, D., & Ryff, C. D. (2002). Optimizing well-being: the empirical encounter of two traditions. Journal of Personal - ity and Social Psychology , 82(6), 1007-1022. doi: 10.1037/0022- 3514.82.6.1007" 561 789 W2466046010.pdf 9 9 separator 0.9543407 ¶ 789 791 W2466046010.pdf 9 10 bibliography 0.99806863 "John, O. P ., & Gross, J. J. (2004). Healthy and unhealthy emotion regulation: Personality processes, individual differences, and life span development. Journal of Personality , 72(6), 1301-1333. DOI: 10.1111/j.1467-6494.2004.00298.x" 791 1034 W2466046010.pdf 9 11 separator 0.92686284 ¶ 1034 1036 W2466046010.pdf 9 12 bibliography 0.998083 "Koole, S. L. (2009). The psychology of emotion regulation: an integrative re - view. Cognition & Emotion, 23 , 4-41. doi: 10.1080/02699930802619031" 1036 1186 W2466046010.pdf 9 13 separator 0.9642074 ¶ 1186 1188 W2466046010.pdf 9 14 bibliography 0.99798524 "Lazarus, R. S. (1991). Emotion and adaptation. New Y ork: Oxford Uni - versity Press." 1188 1277 W2466046010.pdf 9 15 separator 0.95100427 ¶ 1277 1279 W2466046010.pdf 9 16 bibliography 0.99799484 "Livingstone K. M., & Srivastava, S. (2012). Up regulating positive emo - tions in everyday life: strategies, individual differences, and associa - tions with positive emotion and well-being. Journal of Research in Personality, 46 (5), 504-516. doi: 10.1016/j.jrp.2012.05.009" 1279 1561 W2466046010.pdf 9 17 separator 0.9674395 ¶ 1561 1563 W2466046010.pdf 9 18 bibliography 0.9981506 "Lopes, P . N., Salovey, P ., Côté, S., & Beers, M. (2005). Emotion regulation abilities and the quality of social interaction. 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Personality and Individual Differences, 51(5), 589-594. doi: 10.1016/j.paid.2011.05.020" 2804 3062 W2466046010.pdf 9 31 separator 0.9693222 ¶ 3062 3064 W2466046010.pdf 9 32 bibliography 0.9978621 "Mendonça, H., Ferreira, M. C., Porto, J., & Zanini, D. S. (2012). Saúde, qualidade de vida e bem-estar: limites e interfaces teórico-metodo - lógicas. In Saúde e bem-estar no trabalho: dimensões individuais e culturais (pp. 11-34). São Paulo: Casa do Psicólogo." 3064 3334 W2466046010.pdf 9 33 separator 0.9693126 ¶ 3334 3336 W2466046010.pdf 9 34 bibliography 0.99736553 "Nelis, D., Quoidbach, J., Hansenne, M., & Mikolajczak, M. (2011). Measuring individual differences in emotion regulation: The emotion regulation profile-revised (ERP-R). Psychologica Belgica, 51 , 49-91. doi: 10.5334/pb-51-1-49Nyklíček, I., Denollet, J., & Vingerhoets, A. (2011) Emotion regulation: Conceptual an clinical issues. Nova Iorque: Springer." 3336 3703 W2466046010.pdf 9 35 separator 0.94024074 ¶ 3703 3705 W2466046010.pdf 9 36 bibliography 0.9978368 "Preacher, K. J., & Hayes, A. F . (2004). SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behavior Research Methods, Instruments, & Computers , 36(4), 717-731. doi:10.3758/BF03206553" 3705 3932 W2466046010.pdf 9 37 separator 0.9648982 ¶ 3932 3934 W2466046010.pdf 9 38 bibliography 0.99741393 "Queroz, N. C., & Neri, A. L (2005). Bem-estar psicológico e inteligência emocional entre homens e mulheres na meia idade e na velhice . Psicologia: Reflexão e Crítica, 18 (2), 292-299. doi: 10.1590/S0102- 79722005000200018" 3934 4165 W2466046010.pdf 9 39 separator 0.97265345 ¶ 4165 4167 W2466046010.pdf 9 40 bibliography 0.99783176 "Quoidbach, J., & Hansenne, M. (2009). The impact of trait emotional intelligence on nursing team performance and cohesiveness. Journal of Professional Nursing , 25(1), 23-29. doi: 10.1016/j.prof - nurs.2007.12.002" 4167 4389 W2466046010.pdf 9 41 separator 0.9718045 ¶ 4389 4391 W2466046010.pdf 9 42 bibliography 0.99679065 "Quoidbach, J., Berry, E. V ., Hansenne, M., & Mikolajczak, M. (2010). Positive emotion regulation and well-being: comparing the impact of eight savoring and dampening strategies. Personality and Individual Differences, 49 (5), 368-373. doi: 10.1016/j.paid.2010.03.048" 4391 4669 W2466046010.pdf 9 43 separator 0.9691486 ¶ 4669 4671 W2466046010.pdf 9 44 bibliography 0.9980589 "Ryan, R. M., & Deci, E. L. (2001). On happiness and human potentials: a review of research on hedonic and eudaimonic well-being. An- nual Review of Psychology, 52 , 141-166. doi: 10.1146/annurev. psych.52.1.141" 4671 4889 W2466046010.pdf 9 45 separator 0.9751069 ¶ 4889 4891 W2466046010.pdf 9 46 bibliography 0.9980897 "Ryff, C. D. (1989). Happiness is everything, or is it? Explorations on the meaning of psychological well-being. Journal of Personality and So - cial Psychology, 57 , 1069-1081. doi: 10.1037/0022-3514.57.6.1069" 4891 5106 W2466046010.pdf 9 47 separator 0.9672713 ¶ 5106 5108 W2466046010.pdf 9 48 bibliography 0.9980827 "Ryff, C. D., & Keyes, C. L. (1995). The structure of psychological well- being revisited. Journal of Personality and Social Psychology, 69 (4), 719-727. doi: 10.1037/0022-3514.69.4.719" 5108 5298 W2466046010.pdf 9 49 separator 0.96845627 ¶ 5298 5300 W2466046010.pdf 9 50 bibliography 0.9980521 "Ryff, C. D., & Singer B. H. (2008). Know thyself and become what you are: a eudaimonic approach to psychological well-being. Journal of Happiness Studies , 9, 13-39. doi: 10.1007/s10902-006-9019-0" 5300 5503 W2466046010.pdf 9 51 separator 0.9712378 ¶ 5503 5505 W2466046010.pdf 9 52 bibliography 0.9979587 "Ryff, C. D., Keyes, C. L. M., & Hughes, D. L. (2003). 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Psicologia: Teoria e Pesquisa, 24 (2), 201-209. doi: 10.1590/S0102- 37722008000200010." 6036 6267 W2466046010.pdf 9 57 separator 0.96402466 ¶ 6267 6269 W2466046010.pdf 9 58 bibliography 0.9979717 "Sobel, M. E. (1982). Asymptotic confidence intervals for indirect effects in structural equation models. In Leinhardt, S. (Org.), Sociological Methodology (pp. 290-312). Washington DC: American Sociologi - cal Association." 6269 6501 W2466046010.pdf 9 59 separator 0.97290134 ¶ 6501 6503 W2466046010.pdf 9 60 bibliography 0.99793917 "Tamir, M. (2011). The maturing field of emotion regulation. Emotion Review, 3, 3-7. doi: 10.1177/1754073910388685" 6503 6621 W2466046010.pdf 9 61 separator 0.9642148 ¶ 6621 6623 W2466046010.pdf 9 62 bibliography 0.99795663 "T amir, M., Mitchell, C., & Gross, J. J. (2008). Hedonic and instrumental motives in anger regulation. Psychological Science , 19, 324-328. doi: 10.1111/j.1467-9280.2008.02088.x" 6623 6807 W2466046010.pdf 9 63 separator 0.9701191 ¶ 6807 6809 W2466046010.pdf 9 64 bibliography 0.99778676 "Warr, P . (2007). Work, happiness, and unhappiness . Mahwah: Lawrence Erlbaum Associates, Inc." 6809 6907 W2466046010.pdf 9 0 paratext 0.971714 6 Óêðà¿íñüêèй íåйðîõ3ðóðã3чíèй æóðíàë, 13, 2008 0 47 W4238997778.pdf 0 1 separator 0.8975748 ¶ 47 49 W4238997778.pdf 0 2 paratext 0.6298653 "МІНІСТЕРСТВО ОХОРОНИ ЗДОРОВ’Я УКР АЇНИ Н А К А З" 49 100 W4238997778.pdf 0 3 separator 0.51745903 100 101 W4238997778.pdf 0 4 paratext 0.8623345 ¶ 13.06.2008 м. Київ No 317 101 127 W4238997778.pdf 0 5 separator 0.9680097 ¶ 127 129 W4238997778.pdf 0 6 title 0.960494 "Про затвердження клінічних протоколів надання медичної допомоги за спеціальністю «Нейрохірургія»" 129 238 W4238997778.pdf 0 7 separator 0.9746095 ¶ 238 240 W4238997778.pdf 0 8 text 0.9317618 "На виконання доручення Прем’єр-міністра України від 12.03.2003 No14494 до доручення Президента України від 06.03.2003 No1-1/252 щодо прискорення розроблення і запровад - ження протоколів лікування" 240 440 W4238997778.pdf 0 9 separator 0.89840746 ¶ 440 442 W4238997778.pdf 0 10 text 0.9147795 НАКАЗУЮ: 442 451 W4238997778.pdf 0 11 separator 0.7397046 ¶ 451 453 W4238997778.pdf 0 12 text 0.90724826 "1. Затвердити клінічні протоколи надання медичної допомоги за спеціальністю «Ней - рохірургія»:" 453 551 W4238997778.pdf 0 13 separator 0.75937146 ¶ 551 553 W4238997778.pdf 0 14 text 0.95387024 "1.1. Клінічний протокол надання медичної допомоги хворим із абсцесом головного мозку (додається)." 553 654 W4238997778.pdf 0 15 separator 0.59582293 ¶ 654 656 W4238997778.pdf 0 16 text 0.9588973 "1.2. Клінічний протокол надання медичної допомоги хворим із гідроцефалією (додається)." 656 746 W4238997778.pdf 0 17 separator 0.51159453 ¶ 746 748 W4238997778.pdf 0 18 text 0.94660556 "1.3. Клінічний протокол надання медичної допомоги хворим із невралгією трійчастого, язикоглоточного нервів, гемілицевим спазмом, синдромом Меньєра, есенціальною парок - сизмальною артеріальною гіпертензією (додається)." 748 972 W4238997778.pdf 0 19 separator 0.84844494 ¶ 972 974 W4238997778.pdf 0 20 text 0.9649941 "1.4. Клінічний протокол надання медичної допомоги хворим із відкритими пошкоджен - нями хребта та спинного мозку (додається)." 974 1102 W4238997778.pdf 0 21 separator 0.74631655 ¶ 1102 1104 W4238997778.pdf 0 22 text 0.9271184 "1.5. Клінічний протокол надання медичної допомоги хворим із інфекційно-запальними ускладненнями при травмі хребта та спинного мозку (додається)." 1104 1252 W4238997778.pdf 0 23 separator 0.7687544 ¶ 1252 1254 W4238997778.pdf 0 24 text 0.95775807 "1.6. Клінічний протокол надання медичної допомоги хворим із травматичними ушкод - женнями краніовертебральної ділянки (додається)." 1254 1387 W4238997778.pdf 0 25 separator 0.8380613 ¶ 1387 1389 W4238997778.pdf 0 26 text 0.88238233 "1.7. Клінічний протокол надання медичної допомоги хворим із травмою шийного від - ділу хребта та спинного мозку (додається)." 1389 1516 W4238997778.pdf 0 27 separator 0.8218341 ¶ 1516 1518 W4238997778.pdf 0 28 text 0.88802475 "1.8. Клінічний протокол надання медичної допомоги хворим із з травмою грудного та поперекового відділів хребта та спинного мозку (додається)." 1518 1663 W4238997778.pdf 0 29 separator 0.89706516 ¶ 1663 1665 W4238997778.pdf 0 30 text 0.8272936 "1.9. Клінічний протокол надання медичної допомоги хворим із з інфекційно-запальними процесами хребта та спинного мозку (додається)." 1665 1800 W4238997778.pdf 0 31 separator 0.92975175 ¶ 1800 1802 W4238997778.pdf 0 32 text 0.73881483 1.10. Клінічний протокол надання медичної допомоги хворим із з дискогенними нейро - ¶ 1802 1888 W4238997778.pdf 0 33 table 0.49419063 компресійним 1888 1901 W4238997778.pdf 0 34 text 0.49943233 и 1901 1902 W4238997778.pdf 0 35 table 0.498428 синдром 1902 1910 W4238997778.pdf 0 36 text 0.5258168 ами 1910 1913 W4238997778.pdf 0 37 table 0.4847741 попере 1913 1920 W4238997778.pdf 0 38 text 0.49684066 кового відд 1920 1931 W4238997778.pdf 0 39 table 0.49147204 ілу 1931 1934 W4238997778.pdf 0 40 text 0.68252045 хребта (додається). 1934 1954 W4238997778.pdf 0 41 separator 0.823156 ¶ 1954 1956 W4238997778.pdf 0 42 text 0.7346362 "1.11. Клінічний протокол надання медичної допомоги хворим із з дискогенними нейро - компресійними синдромами шийного відділу хребта (додається)." 1956 2103 W4238997778.pdf 0 43 separator 0.91215336 ¶ 2103 2105 W4238997778.pdf 0 44 text 0.88234234 "1.12. Клінічний протокол надання медичної допомоги хворим із з нестабільністю хребта дегенеративно-дистрофічного ґенезу (спондилолістезом, сподилолізом хребта) із невроло - гічними проявами (додається)." 2105 2313 W4238997778.pdf 0 45 separator 0.9949423 ¶ 2313 2315 W4238997778.pdf 0 0 text 0.44018558 1 2 W1771910653.pdf 1 1 separator 0.8555951 ¶ 1 2 W1771910653.pdf 1 2 text 0.99507105 "approach to voltage control in a distribution system by taking in to account of number of DG systems and capacitors under various condition has been presented. Besides offering environmental benefits, integration of modular generating units to distribution network may bring other significant benefits such as increased reliability, loss reduction, load management and also the possibility of delaying the adjustment of transmission and distribution networks [1, 4, 5]." 2 493 W1771910653.pdf 1 3 separator 0.968385 ¶ 494 496 W1771910653.pdf 1 4 text 0.9995167 "In order to achieve these benefits with large penetration of DG source in existing utility network, several technical problems are to be fronted. Some of the technical issues must be considered for successful introduction of DG systems are steady state voltage regulation, increased system fault level, islanding operation, degradation of power quality and reliability, protection and stability of the network [2 ]. These issues are further complicated by the type of interface used for DG system to interconnect it to the grid [3]. One of the major concern is the rise in steady state voltage level of distribution system." 496 1152 W1771910653.pdf 1 5 separator 0.9971293 ¶ 1153 1155 W1771910653.pdf 1 6 title 0.9936415 II. S TEADY STATE VOLTAGE RISE 1155 1187 W1771910653.pdf 1 7 separator 0.9958508 ¶ 1189 1191 W1771910653.pdf 1 8 text 0.9995534 "When the generator is connected to the radial feeder, its active power export reduces the power flow from the primary substation. This causes reduction in the voltage drop along the feeder. If the generator’s power export is larger than the feeder load, power flows from the generator to the primary substation and this causes a voltage rise along the feeder. Typically, worst case scenarios are: a) no generation and maximum system demand, b) maximum generation and maximum system demand, c) maximum generation and minimum system demand. In the context of voltage rise effect, minimum load and maximum generation conditions are usually critical for the amount of generation that can be connected [4]. However, it may also be necessary to consider maximum load and maximum generation conditions for studying voltage rise problem [5]." 1191 2067 W1771910653.pdf 1 9 separator 0.9911774 ¶ ¶ 2068 2074 W1771910653.pdf 1 10 table 0.78825617 "Load DGFeeder line SubstationjX R Z+ =RIgV sVL LjQ P+ gP gQUtility network RS ¶ (a) IRX IR Vs Vg IRR δφ ¶ (b)" 2076 2221 W1771910653.pdf 1 11 separator 0.989018 ¶ 2222 2224 W1771910653.pdf 1 12 caption 0.99531674 Fig. 1 (a). Utility network with wind DG system (b) phasor diagram 2224 2291 W1771910653.pdf 1 13 separator 0.94798285 "¶ ¶" 2292 2302 W1771910653.pdf 1 14 text 0.9951597 "Fig.1 (a) and Fig.1 (b) are illustrates the connection of distributed generator to the distribution network [9]. The active and reactive powers of the generator are gP and gQ respectively. LP and LQrepresent the active and reactive power of the load connected to the distribution system. RI is the net current through the line impedance, jX R Z+ = and RSis the net power injected to network. The substation voltage and connection point voltage are sV and gVrespectively." 2303 2797 W1771910653.pdf 1 15 separator 0.9908998 ¶ 2798 2800 W1771910653.pdf 1 16 math 0.9682986 ") ( ) (L L g g R R RjQ P jQ P jQ P S+ − + = + = (1) * */ ) ( ,g R R R R g rV jQ P I I V S − = = (2) */ ) ( ) (g R R s R s gV jQ P jX R V Z I V V − + + = + = =* */ ) ( / ) (g R R g R R sV R Q X P j V XQ R P V − + + + (3)" 2803 3098 W1771910653.pdf 1 17 separator 0.9466582 ¶ 3099 3101 W1771910653.pdf 1 18 text 0.9382658 Considering the phasor diagram in Fig. 1(b) 3105 3149 W1771910653.pdf 1 19 separator 0.51626015 ¶ 3150 3152 W1771910653.pdf 1 20 math 0.92981344 s R R gV R Q X P V/ ) ( sin − =δ (4) 3161 3225 W1771910653.pdf 1 21 text 0.36725196 3226 3227 W1771910653.pdf 1 22 separator 0.42369968 ¶ 3227 3228 W1771910653.pdf 1 23 text 0.9084786 "Since the voltage angle δis very small, the term ∗−g R RV R Q X P/ ) ( is also very small and can be neglected." 3229 3344 W1771910653.pdf 1 24 separator 0.8518722 ¶ 3345 3347 W1771910653.pdf 1 25 text 0.70980006 Magnitude of voltage rise 3347 3373 W1771910653.pdf 1 26 math 0.5676807 VΔ 3373 3376 W1771910653.pdf 1 27 text 0.7243215 is approximately given by 3376 3401 W1771910653.pdf 1 28 math 0.94388455 "[14] */ ) (g R RV XQ R P V + = Δ */ )) ( ) ((g L g L gV Q Q X R P P − + − = (5)" 3401 3587 W1771910653.pdf 1 29 separator 0.98107004 ¶ 3588 3590 W1771910653.pdf 1 30 text 0.9932113 "The active power produced by embedded generators increase the voltage, whereas the reactive power can further increase or reduce it depending on the type of DG technology. The synchronous generator can generate or absorb reactive power, but the induction generator only consumes reactive power. These outcomes, in combination with the system’s X R/ ratio or distribution network characteristics and load profiles, determine whether the voltage level at the connection point is increasing by increasing the power production of DG or not. In general for a radial system the voltage level decreases along the feeder, from supply end to the end of the feeder" 3591 4280 W1771910653.pdf 1 31 separator 0.98586094 ¶ 4281 4283 W1771910653.pdf 1 32 math 0.95681906 "∑ = ++ + +− +− =n k kk k K k n VjQ P jX RV V 1 1*1 1 1 1) )( ( (6)" 4283 4382 W1771910653.pdf 1 33 separator 0.93961835 ¶ ¶ 4388 4394 W1771910653.pdf 1 34 text 0.9992682 "In [6], the results of some generic studies explaining the voltage rise issue and how it may be overcome are presented. Several methods like reducing primary substation voltage and constraining the generator operation are discussed." 4394 4636 W1771910653.pdf 1 35 separator 0.9619843 ¶ 4637 4639 W1771910653.pdf 1 36 text 0.9988374 "Distribution networks are designed to keep the customer voltage constant within tolerance limit as dictated by statute and has always been a top priority. The range of voltage which must be met under a number of different standards does not exceed ±10%, with some standards being even tighter than this [7]." 4639 4962 W1771910653.pdf 1 37 separator 0.9925207 ¶ 4964 4966 W1771910653.pdf 1 38 table 0.87013143 "Q compensator AVCUtility network OLTC Load DG Feeder line jXR Z+ =sVgV L LjQ P+ gP gQ cQ ¶" 4966 5076 W1771910653.pdf 1 39 separator 0.9825196 ¶ 5078 5080 W1771910653.pdf 1 40 caption 0.9958112 Fig. 2 A simple system illustrati ng the options for voltage regulation 5080 5152 W1771910653.pdf 1 41 separator 0.90662885 ¶ 5153 5155 W1771910653.pdf 1 42 caption 0.4925094 A 5155 5157 W1771910653.pdf 1 43 text 0.81428576 "distributed generator, DG (gP,gQ ) together with a local load (LP, LQ ) and a reactive compensator (CQ )" 5157 5266 W1771910653.pdf 1 44 caption 0.51118743 are 5266 5269 W1771910653.pdf 1 45 text 0.5600039 ¶ 5270 5272 W1771910653.pdf 1 46 caption 0.49807447 5272 5273 W1771910653.pdf 1 47 text 0.49443436 connected 5273 5282 W1771910653.pdf 1 48 caption 0.5818454 to the distribution system through 5282 5317 W1771910653.pdf 1 49 paratext 0.33451298 5317 5318 W1771910653.pdf 1 50 text 0.6706111 a 5318 5319 W1771910653.pdf 1 51 caption 0.46848693 distribution 5319 5332 W1771910653.pdf 1 52 paratext 0.978011 "World Academy of Science, Engineering and Technology International Journal of Electrical and Computer Engineering Vol:5, No:2, 2011 194 International Scholarly and Scientific Research & Innovation 5(2) 2011 scholar.waset.org/1307-6892/2944International Science Index, Electrical and Computer Engineering Vol:5, No:2, 2011 waset.org/Publication/2944" 5332 5689 W1771910653.pdf 1 0 title 0.7234327 Table 1 Table of the comparative specimens consulted. Museum abbreviations are given in the institutional abbreviations section 0 127 W2886891486.pdf 4 1 text 0.49070707 . 127 128 W2886891486.pdf 4 2 separator 0.9949405 ¶ 128 130 W2886891486.pdf 4 3 table 0.52889293 Tax 130 134 W2886891486.pdf 4 4 title 0.48681504 on 134 136 W2886891486.pdf 4 5 table 0.9835586 "Group Museum and specimen number Boa constrictor imperator Boidae AMNH R 155261, AMNH R 155257, AMNH R 77590, AMNH R 74737, AMNH R 57472 Boa constrictor Boidae AMNH R 57467, AMNH R 57476, AMNH R 131475, AMNH R 75478, AMNH R 141144, AMNH R 7204, AMNH R 75267, AMNH R 7118, MCN.D, 333, MCN.D 335, MCN.D 343, MCN.D 344, MCN.D 347, MCN.D 351" 136 486 W2886891486.pdf 4 6 separator 0.57681775 ¶ 486 488 W2886891486.pdf 4 7 table 0.99580604 "Corallus caninus Boidae AMNH R 57788, AMNH R 73347, AMNH R 57816, AMNH R 155265, AMNH R 169154, AMNH R 155260, AMNH R 73347, AMNH R 155264, AMNH R 139338, AMNH R 155263, AMNH R 57816 Crotallus durissus Viperidae AMNH 56455, AMNH 744442 Crotallus durissus terrificus Viperidae AMNH 77027 Clelia clelia Colubroidea AMNH 57797 Bothrops atrox Viperidae AMNH 29885 Bothrops bilineatus Viperidae AMNH R 140856 Corallus cf.C.caninus Boidae AMNH R 57804 Corallus annulatus Boidae AMNH R 114496 Corallus batesi Boidae UFMT-R 05362 Drymarchon corais couperi Colubroidea AMNH R 155299 Eunectes murinus Boidae AMNH 57474, MCN.D 306, MCN.D 316, MCN.D 319, MCN.D 342 Epicrates crassus Boidae MCN-PV DR 0003 Epicrates striatus Boidae AMNH R 140542 Epicrates striatus striatus Boidae AMNH R 155262 Epicrates striatus strigilatus Boidae AMNH 155259, AMNH R 70263, AMNH R 155259 Epicrates striatus fosteri Boidae AMNH R 77633, AMNH R 77057 Corallus cropanii Boidae AMNH R 92997 Corallus hortulanus cookii Boidae AMNH R 141098, AMNH R 74832, AMNH R 7812, AMNH R 75740, AMNH R 57809 Corallus hortulanus Boidae AMNH 104528, AMNH R 57786, MCN-PV DR 0001, UFMT 02389, UFMT 02398 Chironius carinatus Colubroidea AMNH 82841 Dipsas indica Colubroidea AMNH 53780 Drymoluber dichrous Colubroidea AMNH 55847 Dendrophidian nucale Colubroidea AMNH 138461 Erythrolamprus mimus micrurus Colubroidea AMNH 109828 Erythrolamprus bizona Colubroidea AMNH 90018 Epicrates angulifer Boidae AMNH R 77596, AMNH R 114497 Epicrates cenchria Boidae AMNH R 114716, AMNH R 57473, AMNH R 71153, AMNH R 75796, AMNH R 75795, MCN-PV DR 0002 Epicrates inornatus Boidae AMNH 70023 Helicops angulatus Colubroidea AMNH R 139137, AMNH R 155310, AMNH R 56031 Hydrodynastes bicinctus Colubroidea AMNH 60822" 488 2309 W2886891486.pdf 4 8 separator 0.7112778 ¶ 2309 2311 W2886891486.pdf 4 9 paratext 0.38157 (continued on 2311 2325 W2886891486.pdf 4 10 text 0.40340492 next page 2325 2335 W2886891486.pdf 4 11 paratext 0.3787586 ) 2335 2337 W2886891486.pdf 4 12 separator 0.97031534 ¶ 2337 2339 W2886891486.pdf 4 13 paratext 0.9350991 Onary et al. (2018), PeerJ , DOI 10.7717/peerj.5402 5/32 2339 2396 W2886891486.pdf 4 0 title 0.9753352 950 COPULA-BASED NONPARAMETRIC TESTS OF INDEPENDENCE 0 52 W4386425796.pdf 1 1 separator 0.99227524 ¶ 52 54 W4386425796.pdf 1 2 text 0.999624 "introduced a generalized entropy and divergence measure that naturally extend the KL divergence. Tsallis entropy was firstly described by Havrda and Charvat [15] and unearthed by Tsallis [42]. Generalizations of Shannon’s entropy have attracted the attention of many researchers. For recent properties of these generalization measures, we refer to [17, 19, 22, 23, 24, 33, 14, 40]. Also, Tsallis entropy extensions have been performed by some researchers, among which we can mention [41, 20, 21]. Some of these measures can be considered as a statistic for the independence test." 54 644 W4386425796.pdf 1 3 separator 0.9782721 ¶ 644 646 W4386425796.pdf 1 4 text 0.999298 "Ma and Sun [27] introduced the concept of copula entropy by combining the KL divergence and the copula density. They demonstrated that the KL divergence is equal to the negative of copula entropy. The copula entropy was considered as a measure of multivariate association by Blumentritt and Schmid [4]. In this paper, we provide R ́enyi and Tsallis divergence measures based on copula density together with their basic properties. We use these measures to perform two nonparametric tests the independence. These tests are simple to implement and reduce the complexity because they depend only on the copula density. Also, the copula-based R ́enyi and Tsallis divergence measure independence tests provide a bigger power compared to the empirical copula-based test in weak dependency." 646 1443 W4386425796.pdf 1 5 separator 0.96308386 ¶ 1443 1445 W4386425796.pdf 1 6 text 0.99869055 "The rest of the paper is arranged as follows. In Section 2, the copula-based R ́enyi and Tsallis divergence measures together with their basic properties are provided. Estimators of the copula-based R ́enyi and Tsallis divergence measures are considered as test statistics for testing independence, and their consistency is established in Section 3. In Section 4, the simulation results are provided to compare the empirical power of independence tests. Finally, an application of new methods in hydrology is presented in Section 5." 1445 1986 W4386425796.pdf 1 7 separator 0.9967352 ¶ 1986 1988 W4386425796.pdf 1 8 title 0.9933622 2. Copula-based R ́enyi and Tsallis divergence measures 1988 2044 W4386425796.pdf 1 9 separator 0.9964233 ¶ 2044 2046 W4386425796.pdf 1 10 text 0.9558935 The KL divergence between two density functions f1andf2is defined as ¶ 2046 2117 W4386425796.pdf 1 11 math 0.792382 "KL(f1, f2) =Z∞ −∞f1(x) logf1(x) f2(x)dx, α > 0, α̸= 1." 2117 2176 W4386425796.pdf 1 12 separator 0.641363 ¶ 2176 2178 W4386425796.pdf 1 13 text 0.9836498 "This divergence is nonnegative, and KL(f1, f2) = 0 if and only if f1(x) =f2(x). The R ́enyi divergence (or relative R ́enyi entropy) of order αbetween two density functions f1andf2is defined as R" 2178 2377 W4386425796.pdf 1 14 math 0.8422741 "α(f1∥f2) =1 α−1logZ Rfα 1(x)f1−α 2(x)dx, α > 0, α̸= 1, (1) ¶" 2377 2445 W4386425796.pdf 1 15 text 0.87155294 and the Tsallis divergence of order αis defined as ¶ 2445 2498 W4386425796.pdf 1 16 math 0.9071288 "Tα(f1∥f2) =1 α−1Z Rfα 1(x)f1−α 2(x)dx−1 , α > 0, α̸= 1. (2)" 2498 2570 W4386425796.pdf 1 17 separator 0.9773674 ¶ 2570 2572 W4386425796.pdf 1 18 text 0.9994285 "The larger αvalues give the R ́enyi and Tsallis divergence measures dominated by the greatest ratio between the two functions. One of the interesting special cases of the R ́enyi and Tsallis divergence measures occurs for α→1, which gives the KL divergence. We also get the well-known Bhattacharyya distance in the special case where α= 0.5for the R ́enyi divergence. On the other hand, it can be noted that the special case α= 0.5for the Tsallis divergence is equal to the double Hellinger distance between probability distributions." 2572 3115 W4386425796.pdf 1 19 separator 0.9772613 ¶ 3115 3117 W4386425796.pdf 1 20 text 0.9989903 "The R ́enyi and Tsallis divergence measures between a joint density function and the product of its corresponding marginal density functions can be rewritten in terms of the copula density function. The copula function suggested by Sklar [38] has been implemented in a broad spectrum of scientific fields such as hydrology and finance. Let random variables XandYfollow arbitrary marginal cumulative distribution functions FXandFY, respectively. Then there is a copula function Cthat combines these marginal distribution functions to give the joint distribution function FasF(x, y) =C(FX(x), FY(y);θ), where (x, y)∈R2andθis a copula parameter." 3117 3770 W4386425796.pdf 1 21 separator 0.9176415 ¶ 3770 3772 W4386425796.pdf 1 22 text 0.98632693 "Recently, semiparametric methods for the estimation of copula parameter based on minimum Alpha-Divergence are presented in [31], which perform well in small sample size and weak dependency. If Cis an absolutely ¶" 3772 3987 W4386425796.pdf 1 23 paratext 0.47948915 Stat 3987 3992 W4386425796.pdf 1 24 bibliography 0.573609 ., Optim. Inf. Comput. 3992 4014 W4386425796.pdf 1 25 paratext 0.72268844 V ol. 11, September 2023 4014 4039 W4386425796.pdf 1 0 paratext 0.98417354 241 0 3 W2965401189.pdf 4 1 separator 0.50599664 3 4 W2965401189.pdf 4 2 paratext 0.9622818 ¶ Revista Brasileira de História, vol. 39, no 81 • pp. 237-241Memória 4 75 W2965401189.pdf 4 3 separator 0.98335814 ¶ 75 77 W2965401189.pdf 4 4 title 0.9834288 REFERÊNCIAS 77 89 W2965401189.pdf 4 5 separator 0.99462146 ¶ 89 91 W2965401189.pdf 4 6 bibliography 0.99695903 "HESPANHA, António Manuel. A constituição do império português. Revisão de al- guns enviesamentos correntes. In: FRAGOSO, João; GOUVÊA, Maria de Fátima Silva; BICALHO, Maria Fernanda (org.). O Antigo Regime nos Trópicos: a dinâmica imperial portuguesa (séculos XVI-XVIII). Rio de Janeiro: Civilização Brasileira, 2001. p. 165-188." 91 430 W2965401189.pdf 4 7 separator 0.98532504 ¶ 430 432 W2965401189.pdf 4 8 bibliography 0.9951004 "HESPANHA, António Manuel. Por que é que foi ‘portuguesa’ a expansão portuguesa? ou o revisionismo nos trópicos. In: SOUZA, Laura de Mello e; FURTADO, Júnia Ferreira; BICALHO, Maria Fernanda (org.). O governo dos povos. São Paulo: Ala-meda, 2009. p. 39-62." 432 691 W2965401189.pdf 4 9 separator 0.98818064 ¶ 691 693 W2965401189.pdf 4 10 bibliography 0.9946145 "HESPANHA, António Manuel. As Vésperas do Leviathan: instituições e poder político. Portugal – séc. XVII. Coimbra: Almedina, 1994." 693 826 W2965401189.pdf 4 11 separator 0.9841554 ¶ 826 828 W2965401189.pdf 4 12 bibliography 0.9971549 "SCHWARTZ, Stuart B. Burocracia e sociedade no Brasil colonial: o Tribunal Superior da Bahia e seus desembargadores, 1609-1751. [1979]. São Paulo: Companhia das Letras, 2011." 828 1005 W2965401189.pdf 4 13 separator 0.9861187 ¶ 1005 1007 W2965401189.pdf 4 14 bibliography 0.99771094 "WEHLING, Arno; WEHLING, Maria José. Direito e justiça no Brasil colonial: o Tri- bunal da Relação do Rio de Janeiro (1751-1808). Rio de Janeiro: Renovar, 2004." 1007 1169 W2965401189.pdf 4 15 separator 0.991853 ¶ 1169 1171 W2965401189.pdf 4 16 paratext 0.94216114 Texto recebido em 5 de julho de 2019. 1171 1209 W2965401189.pdf 4 17 separator 0.6462327 1209 1210 W2965401189.pdf 4 18 paratext 0.85715663 ¶ Aprovado em 9 de julho de 2019. 1210 1243 W2965401189.pdf 4 0 paratext 0.9885963 Microorganisms 2023 ,11, 1048 2 of 3 0 36 W4366212695.pdf 1 1 separator 0.99240583 ¶ 36 38 W4366212695.pdf 1 2 text 0.9996428 "assays used worldwide for SARS-CoV-2 diagnosis reinforces the need to optimize and constantly update these assays according to SARS-CoV-2 genetic evolution and the future emergence of novel variants [ 16]. In this context, the omicron variant has been highly contagious worldwide, although the severity of the disease has been milder, with a less lethal course for patients. Recent diagnostic strategies have been adopted to either detect viral antigens, i.e., antigen-based immunoassays or human anti-SARS-CoV-2 antibodies, i.e., antibody-based immunoassays, in nasal or oropharyngeal swabs, as well as in blood or saliva samples, even using SARS-CoV-2 serologic methods [ 8,17]. An aspect that has been uncovered only partially, but may soon be the subject of in-depth studies, concerns the dosage of mucosal secretory IgA, especially at the ocular level. The role of mucosal IgA in counteracting SARS-CoV-2 infection, particularly at this site of virus entry, appears to be promising [ 18]. Ultimately, innovative tests such as MqSOFA and NEWS-2 were applied to assess intra-hospital mortality (IHM) and 30-day COVID-19 mortality. MqSOFA, although not able to predict treatment, is easier to use than NEWS-2, especially in the emergency setting and when appropriate [5,6]." 38 1342 W4366212695.pdf 1 3 separator 0.9869365 ¶ 1342 1344 W4366212695.pdf 1 4 text 0.99949354 "There are still many uncertainties regarding knowledge of the virus and disease: are asymptomatic people actually infectious and with what charge? Can swabs alone be considered effective? How long will the vaccine be able to protect us? Why are people infected with SARS-CoV-2 not protected against a second infection? Will the immune shield acquired by the most vaccinated countries be sufficient to protect us from possible variations generated by poorly vaccinated countries? Nor do we know whether individuals who have developed severe symptoms of COVID-19 develop more neutralizing antibodies and thus greater protection against reinfection. Precisely in the case of coronavirus, protection may be short-lived, as several authors have suggested. However, it is also true that high levels of antibodies to pre-existing coronaviruses are associated with mild disease, suggesting that their measurement could be useful in predicting disease severity [ 3]. Epigenetics can help us answer some questions. Epigenetic disturbances in both the host and viruses are a matter of great interest in revealing the disparities in mortality and pathology of COVID-19. In fact, several targets of epigenetic modification in the virus, as well as the host, have been identified, including m6A, ACE2 modifications, etc., which have been linked to various conditions in infected hosts and their pathology [ 3,19]. Finally, considering the emergence of new variants, especially from countries where there has not been much stratification of vaccination, how will the situation evolve in general? From the literature data, it appears that breakthrough infections can significantly enhance -S- and neutralizing antibody responses, indicating a possible benefit from booster vaccinations [ 9,10,20]. It is not excluded that many of these questions may be answered in the second edition (2023) of this Special Issue." 1344 3278 W4366212695.pdf 1 5 separator 0.99502313 ¶ 3278 3280 W4366212695.pdf 1 6 paratext 0.38503876 Author 3280 3287 W4366212695.pdf 1 7 contact 0.58705723 "Contributions: Conceptualization, C.C.; writing and original draft preparation, review and editing, C.C. and J.C.R., resources and software., B.P . and M.G.; visualization and supervision, M.G. " 3287 3484 W4366212695.pdf 1 8 bibliography 0.4134524 ¶ 3484 3485 W4366212695.pdf 1 9 contact 0.46220505 and R.D.G.; project administration and funding acquisition C.C. and J.C.R 3485 3559 W4366212695.pdf 1 10 bibliography 0.42046794 ". All authors have read and agree" 3559 3594 W4366212695.pdf 1 11 paratext 0.29081422 d to the 3594 3603 W4366212695.pdf 1 12 bibliography 0.29507676 published 3603 3612 W4366212695.pdf 1 13 paratext 0.3312119 version of the manuscript 3612 3638 W4366212695.pdf 1 14 text 0.29723755 . 3638 3639 W4366212695.pdf 1 15 separator 0.9586683 ¶ 3639 3641 W4366212695.pdf 1 16 text 0.84890765 "Funding: This research was partially funded by FAR-2021 of the University of Ferrara. John Charles Rotondo is supported by the CHEST Foundation (USA) (ID:7580). It is a part of a Special Issue entitled “Advances in SARS-CoV-2 Infection” by Carlo Contini as Guest Editor." 3641 3916 W4366212695.pdf 1 17 separator 0.98910797 ¶ 3916 3918 W4366212695.pdf 1 18 text 0.80860007 "Acknowledgments: We are deeply thankful to all authors and reviewers who provided their contri- bution to this Special Issue." 3918 4046 W4366212695.pdf 1 19 separator 0.95959866 ¶ 4046 4048 W4366212695.pdf 1 20 text 0.5909735 Conflicts of Interest: The editors declare no conflict of interest. 4048 4114 W4366212695.pdf 1 21 separator 0.99458396 ¶ 4114 4116 W4366212695.pdf 1 22 title 0.65241945 References 4116 4127 W4366212695.pdf 1 23 separator 0.9888552 ¶ 4127 4129 W4366212695.pdf 1 24 bibliography 0.98907375 "1. Contini, C.; Di Nuzzo, M.; Barp, N.; Bonazza, A.; De Giorgio, R.; Tognon, M.; Rubino, S. The novel zoonotic COVID-19 pandemic: An expected global health concern. J. Infect Dev. Ctries. 2020 ,14, 254–264. [CrossRef] [PubMed] 2. Available online: https://www.who.int/emergencies/diseases/novel-coronavirus-2019 (accessed on 29 March 2023)." 4129 4474 W4366212695.pdf 1 0 separator 0.76498115 ¶ 1 2 W1549996419.pdf 17 1 title 0.96841866 Esophageal Speech Enhancement Using a Feature Extr action Method Based on Wavelet Transform 213 2 98 W1549996419.pdf 17 2 separator 0.99519813 ¶ 99 101 W1549996419.pdf 17 3 text 0.9970359 "The behavior of proposed feature extraction method was compared with the performance of several other wavelet functions for evaluation purposes. Comparison results are shown in Table 4 which show that proposed method has better performance than other wavelet based feature extraction methods." 101 404 W1549996419.pdf 17 4 separator 0.9935276 ¶ ¶ 405 411 W1549996419.pdf 17 5 table 0.9925772 "Proposed method Daub 4 wavelet Haar waveletMexican hat wavelet Morlet wavelet Recognition rate 95% 75% 40% 79% 89%" 412 545 W1549996419.pdf 17 6 separator 0.9717876 ¶ 546 548 W1549996419.pdf 17 7 caption 0.83611804 "Table 4. Performance of different wavelet based feature enhanced methods when an ANN is used as identification method." 548 671 W1549996419.pdf 17 8 separator 0.9967792 ¶ 672 674 W1549996419.pdf 17 9 title 0.9906376 4. Conclusions 674 689 W1549996419.pdf 17 10 separator 0.99657017 ¶ 690 692 W1549996419.pdf 17 11 text 0.99951017 "This chapter proposed an alaryngeal speech re storation system, suitable for esophageal and ALT produced speech, based on a pattern reco gnition approach where the voiced segments are replaced by equivalent segments of norm al speech contained in a codebook. Evaluation results show a correct detection of voic ed segment by comparison between their spectrograms to those spectrograms of norm al speech signal. Objective and subjective evaluation results show that the proposed system provides a good improvement in the intelligibility and quality of esophageal produced speech signals. These results show that proposed system is an attractive alternative to enhance the alaryngeal speech signals. This chapter also presents a flexible structure that allows the us e of the proposed system to enhance esophageal and artificial laryinx produced speech signals without further modifications. The proposed system could be used to enhance alaryngeal speech in several practical situations such as te lephone and teleconference systems, thus improving the voice and quality life of alaryngeal people." 692 1827 W1549996419.pdf 17 12 separator 0.996816 ¶ 1828 1830 W1549996419.pdf 17 13 contact 0.899928 Author details 1830 1845 W1549996419.pdf 17 14 separator 0.5386978 1846 1847 W1549996419.pdf 17 15 contact 0.9849857 "¶ Alfredo Victor Mantilla Caeiros Tecnológico de Monterrey, Campus Ciudad de Mexico, México Hector Manuel Pérez Meana Instituto Politécnico Nacional, México" 1847 2012 W1549996419.pdf 17 16 separator 0.9937333 ¶ 2013 2015 W1549996419.pdf 17 17 title 0.9009931 5. References 2015 2029 W1549996419.pdf 17 18 separator 0.9948629 ¶ 2030 2032 W1549996419.pdf 17 19 bibliography 0.994889 "[1] H. K. Barney, H. L. Hawork , F. E., and Dunn, ( 1959), “An experimental transitorized artifcial larynx”,. Bell System Technical Journal, 38, 1337-1356.. [2] G. Aguilar, M. Nakano-Miyatake and H. Perez-Meana, (2005), Alaryngeal Speech Enhancement Using Pattern Recognition Techniques”, IEICE Trans. Inf. & Syst. Vol. E88-D, No. 7, pp. 1618-1622." 2032 2394 W1549996419.pdf 17 0 separator 0.4744231 1 2 W2124500521.pdf 19 1 paratext 0.3667714 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ " 1 61 W2124500521.pdf 19 2 table 0.21907152 ¶ 61 62 W2124500521.pdf 19 3 paratext 0.21966416 64 65 W2124500521.pdf 19 4 table 0.22490637 ¶ 65 66 W2124500521.pdf 19 5 paratext 0.21451993 68 69 W2124500521.pdf 19 6 table 0.22606309 ¶ 69 70 W2124500521.pdf 19 7 separator 0.21530722 72 73 W2124500521.pdf 19 8 table 0.22997561 ¶ 73 74 W2124500521.pdf 19 9 separator 0.2154459 76 77 W2124500521.pdf 19 10 table 0.23166087 ¶ 77 78 W2124500521.pdf 19 11 separator 0.2135355 80 81 W2124500521.pdf 19 12 table 0.23307021 ¶ 81 82 W2124500521.pdf 19 13 separator 0.21489908 84 85 W2124500521.pdf 19 14 table 0.23446263 ¶ 85 86 W2124500521.pdf 19 15 separator 0.21499728 88 89 W2124500521.pdf 19 16 table 0.23384006 ¶ 89 90 W2124500521.pdf 19 17 separator 0.2148227 92 93 W2124500521.pdf 19 18 table 0.23290488 ¶ 93 94 W2124500521.pdf 19 19 separator 0.21403688 96 97 W2124500521.pdf 19 20 table 0.2328783 ¶ 97 98 W2124500521.pdf 19 21 separator 0.2126711 100 101 W2124500521.pdf 19 22 table 0.23585819 ¶ 101 102 W2124500521.pdf 19 23 separator 0.21177804 104 105 W2124500521.pdf 19 24 table 0.23446654 ¶ 105 106 W2124500521.pdf 19 25 separator 0.21270765 108 109 W2124500521.pdf 19 26 table 0.23384188 ¶ 109 110 W2124500521.pdf 19 27 separator 0.21177013 112 113 W2124500521.pdf 19 28 table 0.2333545 ¶ 113 114 W2124500521.pdf 19 29 separator 0.21170409 116 117 W2124500521.pdf 19 30 table 0.23312496 ¶ 117 118 W2124500521.pdf 19 31 separator 0.21112522 120 121 W2124500521.pdf 19 32 table 0.2327718 ¶ 121 122 W2124500521.pdf 19 33 separator 0.20833445 124 125 W2124500521.pdf 19 34 table 0.23199745 ¶ 125 126 W2124500521.pdf 19 35 paratext 0.2100741 128 129 W2124500521.pdf 19 36 table 0.22999898 ¶ 129 130 W2124500521.pdf 19 37 paratext 0.20815349 132 133 W2124500521.pdf 19 38 table 0.23021896 ¶ 133 134 W2124500521.pdf 19 39 paratext 0.20986721 136 137 W2124500521.pdf 19 40 table 0.2293018 ¶ 137 138 W2124500521.pdf 19 41 paratext 0.21218078 140 141 W2124500521.pdf 19 42 table 0.22803137 ¶ 141 142 W2124500521.pdf 19 43 paratext 0.21513972 144 145 W2124500521.pdf 19 44 table 0.22666878 ¶ 145 146 W2124500521.pdf 19 45 paratext 0.21550329 148 149 W2124500521.pdf 19 46 table 0.22670038 ¶ 149 150 W2124500521.pdf 19 47 paratext 0.21693201 152 153 W2124500521.pdf 19 48 table 0.22321129 ¶ 153 154 W2124500521.pdf 19 49 paratext 0.21970123 156 157 W2124500521.pdf 19 50 table 0.2241667 ¶ 157 158 W2124500521.pdf 19 51 paratext 0.22466892 160 161 W2124500521.pdf 19 52 table 0.21980037 ¶ 161 162 W2124500521.pdf 19 53 paratext 0.2286612 164 165 W2124500521.pdf 19 54 table 0.21672522 ¶ 165 166 W2124500521.pdf 19 55 paratext 0.2605307 "¶ ¶ ¶ ¶ ¶" 168 202 W2124500521.pdf 19 56 separator 0.30518866 204 205 W2124500521.pdf 19 57 paratext 0.31034827 ¶ 205 206 W2124500521.pdf 19 58 separator 0.41142425 208 209 W2124500521.pdf 19 59 paratext 0.30329537 ¶ 209 210 W2124500521.pdf 19 60 separator 0.75221175 "¶ ¶" 212 222 W2124500521.pdf 19 61 bibliography 0.5279744 Matth 223 229 W2124500521.pdf 19 62 paratext 0.58946955 yssens et al. Retroperitoneal liposarcoma 229 270 W2124500521.pdf 19 63 separator 0.98777914 ¶ 270 272 W2124500521.pdf 19 64 bibliography 0.9930415 "145. Blay JY, Casali P , Nieto A, Tanovic A, Le Cesne A. Efficacy and safety of trabectedin as an early treatment for advanced or metastatic liposarcoma and leiomyosarcoma. Future Oncol (2014) 10(1):59–68. doi:10.2217/fon.13. " 272 502 W2124500521.pdf 19 65 separator 0.56017274 ¶ 502 503 W2124500521.pdf 19 66 bibliography 0.9794262 163 503 507 W2124500521.pdf 19 67 separator 0.9714283 ¶ 507 509 W2124500521.pdf 19 68 bibliography 0.9973924 "146. Demetri GD, Chawla SP , von Mehren M, Ritch P , Baker LH, Blay JY, et al. Effi- cacy and safety of trabectedin in patients with advanced or metastatic liposar- coma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: results of a randomized phase II study of two different schedules. 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MDM2 small-molecule antagonist RG7112 activates p53 signaling and regresses human tumors in preclinical cancer models. Cancer Res (2013) 73(8):2587–97. doi:10.1158/0008-5472.CAN-12-2807" 1433 1699 W2124500521.pdf 19 75 separator 0.9730215 ¶ 1699 1701 W2124500521.pdf 19 76 bibliography 0.9979928 "150. Ding Q, Zhang Z, Liu JJ, Jiang N, Zhang J, Ross TM, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem (2013) 56(14):5979–83. doi:10.1021/jm400487c" 1701 1913 W2124500521.pdf 19 77 separator 0.96332145 ¶ 1913 1915 W2124500521.pdf 19 78 bibliography 0.9974089 "151. Luke JJ, D’Adamo DR, Dickson MA, Keohan ML, Carvajal RD, Maki RG, et al. The cyclin-dependent kinase inhibitor flavopiridol potentiates doxoru- bicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial. Clin Cancer Res (2012) 18(9):2638–47. doi:10.1158/1078-0432.CCR-11-3203" 1915 2263 W2124500521.pdf 19 79 separator 0.9779351 ¶ 2263 2265 W2124500521.pdf 19 80 bibliography 0.99776924 "152. Demetri GD, Fletcher CD, Mueller E, Sarraf P , Naujoks R, Campbell N, et al. Induction of solid tumor differentiation by the peroxisome proliferator- activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A (1999) 96(7):3951–6. doi:10.1073/pnas.96.7.3951" 2265 2574 W2124500521.pdf 19 81 separator 0.97525007 ¶ 2574 2576 W2124500521.pdf 19 82 bibliography 0.99801755 "153. Debrock G, Vanhentenrijk V , Sciot R, Debiec-Rychter M, Oyen R, Van Oost- erom A. A phase II trial with rosiglitazone in liposarcoma patients. Br J Cancer (2003) 89(8):1409–12. doi:10.1038/sj.bjc.6601306" 2576 2789 W2124500521.pdf 19 83 separator 0.972186 ¶ 2789 2791 W2124500521.pdf 19 84 bibliography 0.99792033 "154. Pishvaian MJ, Marshall JL, Wagner AJ, Hwang JJ, Malik S, Cotarla I, et al. A phase 1 study of efatutazone, an oral peroxisome proliferator-activated receptor gamma agonist, administered to patients with advanced malignancies. Cancer (2012) 118(21):5403–13. doi:10.1002/cncr.27526" 2791 3082 W2124500521.pdf 19 85 separator 0.97245586 ¶ 3082 3084 W2124500521.pdf 19 86 bibliography 0.9977836 "155. Guan M, Fousek K, Jiang C, Guo S, Synold T, Xi B, et al. Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane pro-teolysis of SREBP-1 and ATF6. Clin Cancer Res (2011) 17(7):1796–806. doi:10.1158/1078-0432.CCR-10-3216" 3084 3343 W2124500521.pdf 19 87 separator 0.96179974 ¶ 3343 3345 W2124500521.pdf 19 88 bibliography 0.9978541 "156. Pan J, Mott M, Xi B, Hepner E, Guan M, Fousek K, et al. Phase I study of nelfinavir in liposarcoma. Cancer Chemother Pharmacol (2012) 70(6):791–9. doi:10.1007/s00280-012-1961-4" 3345 3530 W2124500521.pdf 19 89 separator 0.9740051 ¶ 3530 3532 W2124500521.pdf 19 90 bibliography 0.99636006 "157. Mahmood ST, Agresta S, Vigil CE, Zhao X, Han G, D’Amato G, et al. Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent his- tologies: leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma. Int J Cancer (2011) 129(8):1963–9. doi:10.1002/ijc.25843" 3532 3911 W2124500521.pdf 19 91 separator 0.9810052 ¶ 3911 3913 W2124500521.pdf 19 92 bibliography 0.9975418 "158. Cassier PA, Lefranc A, Amela EY, Chevreau C, Bui BN, Lecesne A, et al. A phase II trial of panobinostat in patients with advanced pretreated soft tissue sarcoma. A study from the French Sarcoma Group. Br J Cancer (2013) 109(4):909–14. doi:10.1038/bjc.2013.442" 3913 4184 W2124500521.pdf 19 93 separator 0.9778042 ¶ 4184 4186 W2124500521.pdf 19 94 bibliography 0.99641603 "159. Sleijfer S, Ray-Coquard I, Papai Z, Le Cesne A, Scurr M, Schoffski P , et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a phase II study from the Euro- pean organisation for research and treatment of cancer-soft tissue and bone sarcoma group (EORTC study 62043). J Clin Oncol (2009) 27(19):3126–32. doi:10.1200/JCO.2008.21.3223" 4186 4606 W2124500521.pdf 19 95 separator 0.97928345 ¶ 4606 4608 W2124500521.pdf 19 96 bibliography 0.99768573 "160. von Mehren M, Rankin C, Goldblum JR, Demetri GD, Bramwell V , Ryan CW, et al. Phase 2 Southwest Oncology Group-directed intergroup trial (S0505) of sorafenib in advanced soft tissue sarcomas. Cancer (2012) 118(3):770–6. doi:10.1002/cncr.26334" 4608 4862 W2124500521.pdf 19 97 separator 0.98978573 ¶ 4862 4864 W2124500521.pdf 19 98 paratext 0.4676284 Conflict 4864 4872 W2124500521.pdf 19 99 text 0.38477263 of Interest Statement 4872 4894 W2124500521.pdf 19 100 paratext 0.521323 : 4894 4895 W2124500521.pdf 19 101 text 0.72695947 "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as" 4895 5037 W2124500521.pdf 19 102 paratext 0.55055386 5037 5038 W2124500521.pdf 19 103 text 0.721282 a potential conflict of interest. 5038 5070 W2124500521.pdf 19 104 separator 0.86428356 ¶ 5070 5072 W2124500521.pdf 19 105 paratext 0.98085594 "Received: 30 October 2014; accepted: 28 January 2015; published online: 10 February 2015." 5072 5164 W2124500521.pdf 19 106 separator 0.9717442 ¶ 5164 5166 W2124500521.pdf 19 107 paratext 0.85234255 Citation: 5166 5176 W2124500521.pdf 19 108 bibliography 0.7677457 "Matthyssens LE, Creytens D and Ceelen WP (2015) Retroperitoneal liposarcoma: current insights in diagnosis and treatment" 5176 5299 W2124500521.pdf 19 109 paratext 0.59109867 . Front. Surg. 2:4. doi: 5299 5324 W2124500521.pdf 19 110 bibliography 0.5059689 ¶ 5324 5325 W2124500521.pdf 19 111 paratext 0.8695487 "10.3389/fsurg.2015.00004 This article was submitted to Surgical Oncology, a section of the journal Frontiers in Surgery." 5325 5450 W2124500521.pdf 19 112 separator 0.59215075 ¶ 5450 5452 W2124500521.pdf 19 113 paratext 0.9756064 "Copyright © 2015 Matthyssens, Creytens and Ceelen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)." 5452 5617 W2124500521.pdf 19 114 separator 0.55391145 ¶ 5617 5619 W2124500521.pdf 19 115 paratext 0.94909805 "The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms." 5619 5947 W2124500521.pdf 19 116 separator 0.98542804 ¶ 5947 5949 W2124500521.pdf 19 117 paratext 0.90829986 Frontiers in Surgery | Surgical Oncology February 2015 | Volume 2 | Article 4 | 20 5949 6032 W2124500521.pdf 19 0 paratext 0.9265049 18 D. Stokols, S. A. Shumaker and J. Martinez 0 45 W1987601846.pdf 14 1 separator 0.95147455 ¶ 46 48 W1987601846.pdf 14 2 bibliography 0.99735326 "Fischer, C. S. and Stueve, C. A. (1977). Authentic community: the role of place in modern life. In C. S. Fischer, R. M. Jackson, C. A. Stueve, K. Gerson, L. M. Jones and M. Baldassare (eds), Networks and Places: Social Relations in the Urban Setting, 163-86. New York: The Free Press." 48 342 W1987601846.pdf 14 3 separator 0.97251976 ¶ 343 345 W1987601846.pdf 14 4 bibliography 0.99264735 "Fried, M. (1963). Grieving for a lost home. In L. J. Duhl (ed.), The Urban Condition, 151-71. New York: Basic Books." 345 465 W1987601846.pdf 14 5 separator 0.95875406 ¶ 466 468 W1987601846.pdf 14 6 bibliography 0.998005 "Harrison, R. V. (1978). Person-environment fit and job stress. In C. L. Cooper and R. Payne (eds), Stress at Work, 175-205. New York: John Wiley & Sons." 468 624 W1987601846.pdf 14 7 separator 0.97372204 ¶ 625 627 W1987601846.pdf 14 8 bibliography 0.9979784 "Holmes, T. H. and Rahe, R. H. (1967). The social readjustment rating scale. Journal of Psycho- somatic Research, 11, 213-8." 627 754 W1987601846.pdf 14 9 separator 0.96195656 ¶ 755 757 W1987601846.pdf 14 10 bibliography 0.9975978 "Hormuth, S. E. (1983). Transitions in commitments to roles and self-concept change: Relocation as a paradigm. In V. Allen and E. van de Vliert (eds), Role Transitions. New York: Plenum Press." 757 955 W1987601846.pdf 14 11 separator 0.974833 ¶ 956 958 W1987601846.pdf 14 12 bibliography 0.9978029 "Janowitz, M. (1967). The Community Press in an Urban Setting, 2nd ed. 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The Geographical Mobility of Americans: An International Comparison. Current Population Reports, Special Studies, Series P-23, No. 64. Washington, D.C.: U.S. Bureau of the Census, Government Printing Office." 1560 1815 W1987601846.pdf 14 21 separator 0.9734385 ¶ 1816 1818 W1987601846.pdf 14 22 bibliography 0.99795306 "Long, L. H. and DeAre, D. (1981). Population Redistribution: 1960-1980. Washington, D.C.: U.S. Bureau of the Census, Government Printing Office." 1818 1966 W1987601846.pdf 14 23 separator 0.9719936 ¶ 1967 1969 W1987601846.pdf 14 24 bibliography 0.99814004 "Marx, M. B., Garrity, T. F. and Bowers, F. R. (1975). The influence of recent life experience on the health of college freshmen. Journal of Psychosomatic Research, 19, 87-98." 1969 2147 W1987601846.pdf 14 25 separator 0.97319573 ¶ 2148 2150 W1987601846.pdf 14 26 bibliography 0.996391 "Michelson, W. (1976). Man and His Urban Environment: A Sociological Approach, 2nd ed. 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Spielberger (eds), Stress & Anxiety, Volume 6. Washington, D.C.: Hemisphere Press, 27-53." 3692 3868 W1987601846.pdf 14 49 separator 0.9729872 ¶ 3869 3871 W1987601846.pdf 14 50 bibliography 0.99789196 "Stokols, D. (1982). Environmental psychology: A coming of age. In A. Kraut (ed.), The G. Stanley Hall Lecture Series, Volume 2. Washington, D.C.: American Psychological Association, 1982." 3871 4065 W1987601846.pdf 14 51 separator 0.9795585 ¶ 4066 4068 W1987601846.pdf 14 52 bibliography 0.9981146 "Stokols, D., Novaco, R. W., Stokols, J. and Campbell, J. (1978). Traffic congestion, Type-A behavior, and stress. Journal of Applied Psychology, 63, 467-80." 4068 4228 W1987601846.pdf 14 53 separator 0.98025703 ¶ 4229 4231 W1987601846.pdf 14 54 bibliography 0.9977431 Stokols, D. and Shumaker, S. A. (1981). People in places: A transactional view of settings. 4231 4323 W1987601846.pdf 14 55 separator 0.9806758 ¶ 4324 4326 W1987601846.pdf 14 0 paratext 0.98914486 Molecules 2019 ,24, 2989 2 of 20 0 32 W2968166477.pdf 1 1 separator 0.99527633 ¶ 32 34 W2968166477.pdf 1 2 text 0.99965775 "Recently, metabolomics combined with multivariate data analysis (MVA) has proven to be an ecient tool to predict bioactive constituents in NP research [ 3–7]. Metabolomics aims at providing comprehensive qualitative and quantitative analysis of the whole set of metabolites (metabolome) present in a complex biological sample [ 8,9]. The most used analytical techniques in metabolomics are nuclear magnetic resonance (NMR) and mass spectrometry (MS) [10]. Generally metabolite profiling of natural extracts is achieved via high resolution ultra-high performance liquid chromatography (UHPLC), coupled to high resolution tandem mass spectrometry (HRMS2), which provides molecular formula and fragmentation information on most NPs in extracts in an untargeted manner [ 11]." 34 820 W2968166477.pdf 1 3 separator 0.8460543 ¶ 820 822 W2968166477.pdf 1 4 text 0.99911314 "Unsupervised or supervised multivariate data analysis such as principal components analysis (PCA) or orthogonal partial least squares (OPLS) are then needed to mine such data and highlight biomarkers." 822 1025 W2968166477.pdf 1 5 separator 0.8786469 ¶ 1025 1027 W2968166477.pdf 1 6 text 0.99962866 "Alternative strategies have been developed to explore LC-HRMS2metabolite profiling datasets with the aim of highlighting structural similarities between analytes and e ciently identify new compounds with potential therapeutic interest. Molecular network analysis (MN) [ 12,13] is a computer-based approach allowing the organization of fragmentation spectra from MS-based metabolomics experiments in order to dereplicate and eventually prioritize natural products of interest [ 14–16]. MN is generated based on the similarities of fragmentation patterns and, thus, indirectly allows the grouping of analytes with closely related structures. Networks can be built using the Global Natural Product Social Molecular Networking (GNPS) platform [17] or software such as Metgem or MS-Dial [18,19]." 1027 1832 W2968166477.pdf 1 7 separator 0.98686147 ¶ 1832 1834 W2968166477.pdf 1 8 text 0.9997088 "Bacopa is a genus of aquatic plants belonging to the Plantaginaceae family. Three species occur in Thailand: B. monnieri ,B. caroliniana and B. floribunda [20]. Among them, only B. monnieri (Brahmi) has been reported as a herbal medicine in Ayurvedic medicine for learning and memory improvement [ 21]." 1834 2140 W2968166477.pdf 1 9 separator 0.88653374 ¶ 2140 2142 W2968166477.pdf 1 10 text 0.99973196 "The safety and e cacy of Brahmi extracts in animal models [ 22,23] and in clinical trials [ 24–28] have been proven and support its traditional uses. Intake of Brahmi has been reported to exert undesirable e ects on the gastrointestinal tract, such as nausea, increased stool frequency and abdominal cramps [ 25,29], which might be explained by a cholinergic e ect [30]. In addition, severe liver toxicity has been detected in women taking Brahmi products for vitiligo disease. Nevertheless, their liver function returned to normal after discontinuation of products’ usage [ 31]. Other reports however indicated that Brahmi possessed hepatoprotective activity [ 32,33]. Notwithstanding such adverse e ects and considering the positive e ects of the plant in relation with cognition improvements, further investigations are still worth to identify bioactive principles." 2142 3032 W2968166477.pdf 1 11 separator 0.9852553 ¶ 3032 3034 W2968166477.pdf 1 12 text 0.9997475 "The compounds responsible for the memory enhancing e ects of Brahmi have been reported to be triterpenoid saponins i.e., bacoside A 3, bacopaside I, bacopaside II, bacopasaponin C and bacopaside X [34,35]. They are considered as markers of Brahmi [ 36–41], and their level is assessed for quality control purposes. Usually, the level of plant specialized metabolites is highly variable according to environmental factors. In Brahmi, the levels of such markers were found to vary significantly depending on the part of used (leaves, stems, shoots etc.), collection area and season [42–45]." 3034 3633 W2968166477.pdf 1 13 separator 0.9163402 ¶ 3633 3635 W2968166477.pdf 1 14 text 0.99974656 "Moreover, this plant also contains other classes of NPs such as sterols [ 46], flavonoids [ 47] and phenylethanoids [ 48,49] that may play roles in the pharmacological activities of the plant. It has also been reported that part of the neuroprotective e ects of Brahmi appeared to result from its antioxidant activities that suppress neuronal oxidative stress. Brahmi has been found to inhibit the lipid peroxidation reaction of brain homogenate in a dose-dependent manner [50]." 3635 4122 W2968166477.pdf 1 15 separator 0.97819865 ¶ 4122 4124 W2968166477.pdf 1 16 text 0.9997047 "In this study, we aimed at searching for compounds that could be involved in the memory improvement activity of Brahmi through lipid peroxidation inhibitory activity. In addition, the anti-lipid peroxidation activity of two other Bacopa species has been investigated. To achieve these goals, a metabolomic strategy combining multivariate data analysis (MVA) and bioactivity informed molecular maps [ 14] was used as a guide to highlight bioactive constituents early in the phytochemical study process and directly target their isolation." 4124 4672 W2968166477.pdf 1 0 paratext 0.94615835 "International Journal of Information Sciences and Techniques (IJIST) Vol.6, No.1/2, March 2016 271 ¶" 0 104 W2338248104.pdf 2 1 separator 0.84451914 ¶ ¶ 106 112 W2338248104.pdf 2 2 title 0.6992238 Scenario Trust Multi-Domain TOrBAC 112 149 W2338248104.pdf 2 3 table 0.40180787 150 151 W2338248104.pdf 2 4 text 0.43405986 TCC 151 154 W2338248104.pdf 2 5 table 0.43363503 -P MTB-AC 154 163 W2338248104.pdf 2 6 separator 0.4890198 ¶ 165 167 W2338248104.pdf 2 7 title 0.5129352 and 168 172 W2338248104.pdf 2 8 table 0.9556833 "risk Confidentiality Very Increase Increase Good Increase good ¶ Integrity Increase Increase Very good Increase Very good ¶ Trust Increase Increase Very good Increase Very good ¶ Risk Yes No No Yes No ¶" 172 427 W2338248104.pdf 2 9 separator 0.70108956 434 435 W2338248104.pdf 2 10 table 0.59046173 ¶ 435 436 W2338248104.pdf 2 11 separator 0.98818517 ¶ 438 440 W2338248104.pdf 2 12 title 0.98714674 Table 1.Comparision on Different Model 440 479 W2338248104.pdf 2 13 separator 0.97189915 ¶ 481 483 W2338248104.pdf 2 14 title 0.98342514 5. MTBAC 483 492 W2338248104.pdf 2 15 separator 0.9735934 ¶ ¶ 493 499 W2338248104.pdf 2 16 text 0.9968127 "A term “Mutual Trust” means a reliable interaction among user and cloud service node with considering their behavior and trust. Access control is an important measure to ensure the security of cloud. It is a policy or procedure that allows, denies or restricts access to a system. Access control may also identify user attempting to access the system unauthorized." 499 873 W2338248104.pdf 2 17 separator 0.74851704 "¶ " 874 883 W2338248104.pdf 2 18 math 0.37728742 ¶ 883 884 W2338248104.pdf 2 19 separator 0.3277928 886 887 W2338248104.pdf 2 20 math 0.39785922 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 887 940 W2338248104.pdf 2 21 separator 0.32100806 942 943 W2338248104.pdf 2 22 math 0.3411406 ¶ 943 944 W2338248104.pdf 2 23 separator 0.75876456 "¶ ¶ ¶" 946 960 W2338248104.pdf 2 24 caption 0.9860761 Figure1. Mutual trust structure 960 992 W2338248104.pdf 2 25 separator 0.96161044 ¶ ¶ 997 1003 W2338248104.pdf 2 26 caption 0.90268534 The Algorithm of MTBAC: 1003 1027 W2338248104.pdf 2 27 text 0.45877957 ¶ 1030 1033 W2338248104.pdf 2 28 table 0.48982495  1033 1034 W2338248104.pdf 2 29 text 0.5836925 User request valid or not checked by AAC 1034 1077 W2338248104.pdf 2 30 table 0.5005074  ¶ 1077 1080 W2338248104.pdf 2 31 text 0.59080386 1080 1081 W2338248104.pdf 2 32 table 0.4838006  1081 1082 W2338248104.pdf 2 33 text 0.6205936 AAC checks the user’s behavior  1082 1116 W2338248104.pdf 2 34 table 0.5252076 1116 1117 W2338248104.pdf 2 35 text 0.55994785 ¶ 1117 1119 W2338248104.pdf 2 36 table 0.5089668  1119 1120 W2338248104.pdf 2 37 text 0.60004294 Read the users request and assign 1120 1154 W2338248104.pdf 2 38 table 0.5930171 cloud 1154 1160 W2338248104.pdf 2 39 text 0.5500555 node 1160 1165 W2338248104.pdf 2 40 table 0.558799 to 1165 1168 W2338248104.pdf 2 41 text 0.48699728 handle 1168 1175 W2338248104.pdf 2 42 table 0.4843301 the 1175 1179 W2338248104.pdf 2 43 text 0.5204642 request 1179 1187 W2338248104.pdf 2 44 table 0.5474371 in 1187 1190 W2338248104.pdf 2 45 text 0.4829979 1190 1191 W2338248104.pdf 2 46 table 0.55230564 queue  ¶ 1191 1201 W2338248104.pdf 2 47 text 0.6021477 1201 1202 W2338248104.pdf 2 48 table 0.56723535  1202 1203 W2338248104.pdf 2 49 text 0.618655 Select the best 1203 1219 W2338248104.pdf 2 50 table 0.49436706 service 1219 1227 W2338248104.pdf 2 51 text 0.6103871 node in the node queue 1227 1250 W2338248104.pdf 2 52 table 0.49432772 and 1250 1254 W2338248104.pdf 2 53 text 0.5848107 give the service access 1254 1278 W2338248104.pdf 2 54 table 0.49778274 right 1278 1284 W2338248104.pdf 2 55 text 0.5035191 to 1284 1287 W2338248104.pdf 2 56 table 0.5455654 user 1287 1293 W2338248104.pdf 2 57 text 0.52042735  1293 1295 W2338248104.pdf 2 58 table 0.51813775 ¶ 1295 1297 W2338248104.pdf 2 59 text 0.6373747  Service provide to the user and updates 1297 1339 W2338248104.pdf 2 60 table 0.52264917 users trust 1339 1351 W2338248104.pdf 2 61 text 0.546314 degree 1351 1358 W2338248104.pdf 2 62 table 0.58633834  1358 1359 W2338248104.pdf 2 63 separator 0.95551026 "¶ ¶ ¶" 1359 1373 W2338248104.pdf 2 0 text 0.99948597 "122(31) reported an increase in sway amplitude, together with increased muscular co-contraction, especially when per - forming dual tasks. Kang et al. (31) further suggested that increased co-contractions slow and hamper the ability to generate the corrective reactions to environmental pertur - bations (slips and trips) leading to falls. This could worsen with a feeling of insecurity and/or post fall anxiety, known to affect especially older fallers (38). The feeling of insecu - rity could increase muscle activity, reported by Kang et al. (31) as co-contraction and worsen already slowed postural reaction to perturbations, having an overall destabilizing ef - fect for which the body systems cannot (due to age-related changes) compensate. For all the above reasons we support the idea that BSV increases, reported also in our findings, represent a substantial danger to the overall postural stability and that BS velocity, once extracted from platform stabilom - etry measurements, and might further serve as an indicator of progressive age-related changes in physical functioning." 0 1116 W2070090707.pdf 5 1 separator 0.94416094 ¶ 1117 1119 W2070090707.pdf 5 2 text 0.9994224 "This further leads us to reflect on how to account for BSV age-related changes when designing a corrective ther - apy. From the literature we know that corrective therapy usually focuses on BSD by encouraging yoga, Pilates, mus - cle strengthening and more recently balance training (24); and the focus on BSD might be the reason why such correc - tive therapies were not evaluated as very effective. Based on our results we would suggest evaluations targeting rather BSV when measuring effects of intervention/exercise." 1119 1655 W2070090707.pdf 5 3 separator 0.98178554 ¶ 1655 1657 W2070090707.pdf 5 4 text 0.9997474 "Due to age-related changes in BSV , reflecting to a greater extent changes in nerve conduction velocity and accuracy, as discussed above, we may need a different exercise. Several authors (V ojta, Vele) have suggested this exercise focus - ing more on joint flexibility and muscle synergies, while stimulating inborn locomotor patterns (39, 40). These were described by V ojta, Vele, Panjabi (39–41) and linked with correct breathing patterns (39). Such exercising could have rather a ‘stimulating and reassuring’ effect that might help to compensate for stiffness induced co-contractions and support the ability to generate corrective reactions to envi - ronmental perturbations, especially in fallers. Interventions targeting joint flexibility and muscle strengthening were recently introduced by Mazzeo et al. (42), but without en - couraging findings, Mazzeo (42) focused on root joints only. When spine flexibility and strengthening exercising were added, Danneels et al. (43) and Hides et al. (44), combining stabilization training together with dynamic static resistance, reported more encouraging findings. In addition better spine flexibility was found to improve functional reach, decrease functional limitations and improve balance control in the elderly (24, 45–47). To demonstrate better these mechanisms further research is needed." 1657 3018 W2070090707.pdf 5 5 separator 0.98543227 ¶ 3018 3020 W2070090707.pdf 5 6 text 0.9997269 "Finally we have also noted that BS velocity starts to change more steeply around the age of 80 (Fig. 4 Line chart). Our results have shown this trend in both tests of quiet stand - ing. Results from more difficult tests show an even steeper increase in BS velocity from age of 80 onwards. However further research is also needed to find more general patterns." 3020 3387 W2070090707.pdf 5 7 title 0.98527735 Limitations of the study 3387 3412 W2070090707.pdf 5 8 separator 0.9928584 ¶ 3412 3414 W2070090707.pdf 5 9 text 0.9991829 "Participants and Care Homes were not randomly chosen this might be a limiting factor in terms of the generalizability of our results. Also we would like to add that in this study we were comparing older adults with different levels of physical activity. We have tried to make both samples comparable as to their function, mobility and ability to complete the testing without help (see inclusion and exclusion criteria) but we are aware that there are still few limitations that need addressing. One limitation arises from different mean age of the groups. On one hand this has been addressed in methods in participants section (inclusion and exclusion criteria) and data analysis section (where for Ray Charts we have adjust - ed for age so both samples are in the same age range). On the other hand as one of the aims of this observational study was looking onto how PS indicators (BSV and BSD) change with increasing age we think that differences in mean age between he groups might not be that limiting after all. An - other limitation might be that even if we reduced the number of drugs being taken by 3, there still may be some drug interactions we are not aware of which of course is, to some extent, limiting results of this study. On the other hand there were few authors in the past (i.e. Stelmach) that argued for less tight exclusion criteria as it might be altering the picture of the elderly population." 3414 4864 W2070090707.pdf 5 10 separator 0.9633891 ¶ 4864 4866 W2070090707.pdf 5 11 text 0.9997522 "Another limitation might be that platform stabilometry as a method is not very sensitive to changes in motivation, moods or emotions, as these are difficult to assess in real time measurement. Also questionnaires assessing falls, dizziness, levels of PA and social activity in this study were used only to interpret results. Further research would be focused on using more precisely coded levels of social and physical activity and on exercising involving spine flexibility." 4866 5344 W2070090707.pdf 5 12 separator 0.9961728 ¶ 5344 5346 W2070090707.pdf 5 13 title 0.9899454 Conclusions 5346 5358 W2070090707.pdf 5 14 separator 0.99605155 ¶ 5358 5360 W2070090707.pdf 5 15 text 0.99940944 "Postural stability (PS) has been assessed using five various indicators in two different groups of volunteers (a Third Age University group and a Residential Care Home group). Levels of usual physical and social activities were also assessed in all participants. PS in the Residential Care Home group was significantly worse than the results of the Third Age University group. This difference, we suggest, can be attributed not only to age-related changes but also to reduced physical and social activity in the Care Home group. This study has shown that it is beneficial to divide PS indicators into BS deviation and BS velocity and ob - serve age-related changes affecting BS Deviation (BSD) and BS Velocity (BSV) in different ways. Our results indicate that the age-dependent indicator is BSV rather than BSD, and that BSV contributes to overall PS more than BSD, which is in agreement with previous studies. Therefore we suggest that BSV needs to be accounted for when designing the physical activity to prevent falls in the ¶ elderly." 5360 6411 W2070090707.pdf 5 0 paratext 0.9824945 "IJASOS - International E -Journal of Advances in Social Sciences, Vol. VII, Issue 19, April 2021 ¶ http://ijasos.ocerintjournals.org 123" 0 144 W3119612974.pdf 3 1 separator 0.99507177 ¶ 145 147 W3119612974.pdf 3 2 text 0.9982767 "Since the problem is static, we introduce a spatial coordinate system, combining its beginning with the point , and compose 6 static equilibrium equations:" 148 308 W3119612974.pdf 3 3 separator 0.7990085 ¶ 310 312 W3119612974.pdf 3 4 math 0.6842711 "∑ ∑ ∑ ∑ ∑ ∑ ¶" 312 407 W3119612974.pdf 3 5 separator 0.91068816 ¶ 415 417 W3119612974.pdf 3 6 text 0.9990771 "This problem can be considered only using the definitions and concepts of theoretical mechanics, applying the concepts o f higher mathematics, but in case of interdisciplinary interaction, it is more preferable to implement previously studied concepts of higher mathem atics. P ractical working experience with students shows that this approach is more effective." 417 794 W3119612974.pdf 3 7 separator 0.987253 ¶ 796 798 W3119612974.pdf 3 8 text 0.9929403 "Mathematical part of the problem: it is necessary to determine the coordinates of the points of application of vectors and their projections on the coordinate axis." 798 966 W3119612974.pdf 3 9 separator 0.97665644 ¶ 968 970 W3119612974.pdf 3 10 text 0.46962747 At 970 973 W3119612974.pdf 3 11 table 0.3944511 point forces 973 996 W3119612974.pdf 3 12 text 0.34151906 ⃗ 997 999 W3119612974.pdf 3 13 math 0.36507428 and 1009 1015 W3119612974.pdf 3 14 text 0.41109753 ⃗ 1015 1016 W3119612974.pdf 3 15 math 0.37207276 1026 1027 W3119612974.pdf 3 16 text 0.37026253 . 1027 1028 W3119612974.pdf 3 17 table 0.4279367 ¶ At point forces 1029 1073 W3119612974.pdf 3 18 math 0.36785334 ⃗ 1073 1074 W3119612974.pdf 3 19 table 0.41850805 and 1085 1089 W3119612974.pdf 3 20 math 0.3853604 ⃗ 1090 1116 W3119612974.pdf 3 21 table 0.36568478 . 1116 1119 W3119612974.pdf 3 22 math 0.32363236 ¶ 1119 1120 W3119612974.pdf 3 23 table 0.43532068 "At point " 1120 1149 W3119612974.pdf 3 24 math 0.37147877 ¶ 1149 1150 W3119612974.pdf 3 25 table 0.4723424 ¶ force 1162 1175 W3119612974.pdf 3 26 math 0.3556307 1175 1176 W3119612974.pdf 3 27 table 0.38942865 s 1176 1177 W3119612974.pdf 3 28 math 0.38963234 ⃗ 1178 1189 W3119612974.pdf 3 29 table 0.35019335 . 1189 1190 W3119612974.pdf 3 30 separator 0.8078239 ¶ 1191 1193 W3119612974.pdf 3 31 text 0.99478066 "It is not difficult to make up the first three equations of statics – just add up the corresponding projections of forces:" 1193 1319 W3119612974.pdf 3 32 separator 0.8943881 ¶ ¶ 1321 1372 W3119612974.pdf 3 33 text 0.96638805 "Students have much more difficulties with equations of moments of forces relative to coordinate axes. Here higher mathematics comes to the rescue – we apply the mechanical meaning of the vector [ ⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗⃗ ] (the vector moment of force relative to the origin). Let’s create determina nts:" 1372 1693 W3119612974.pdf 3 34 separator 0.69862723 ¶ 1694 1696 W3119612974.pdf 3 35 table 0.99260575 "⃗⃗ ( ⃗ ) | ⃗ ¶ | ⃗⃗ ( ⃗ ) | ⃗ ¶ | ⃗⃗ ( ⃗ ) | ⃗ ¶ | ⃗⃗ ( ⃗ ) | ⃗ ¶ | ⃗⃗ ( ⃗ ) | ⃗ ¶ ¶ |" 1697 1952 W3119612974.pdf 3 36 separator 0.9831414 ¶ 1954 1956 W3119612974.pdf 3 37 text 0.958434 "By revealing the determinants according to the first line and correlating the obtained minors, we can write the remaining three equations, taking into account that t he obtained coefficients for unit vectors are projections of the vector moment on the coordinate axis: ¶ " 1956 2280 W3119612974.pdf 3 38 math 0.37364355 ¶ 2280 2281 W3119612974.pdf 3 39 text 0.442117 2308 2309 W3119612974.pdf 3 40 math 0.3549373 ¶ 2309 2310 W3119612974.pdf 3 41 text 0.517447 ¶ 2324 2371 W3119612974.pdf 3 42 separator 0.47877416 ¶ 2371 2372 W3119612974.pdf 3 43 text 0.99257207 The last equation is transformed into a valid identity. 2372 2428 W3119612974.pdf 3 44 separator 0.9049766 ¶ 2430 2432 W3119612974.pdf 3 45 text 0.986764 From the geometric relations, we get: . 2432 2485 W3119612974.pdf 3 46 separator 0.9813596 ¶ 2486 2488 W3119612974.pdf 3 47 text 0.9655641 Let's put all the equations into a system: 2488 2531 W3119612974.pdf 3 48 separator 0.8146757 ¶ 2533 2535 W3119612974.pdf 3 49 math 0.5900543 "{ ¶ ¶ ¶ { ¶ ¶" 2535 2726 W3119612974.pdf 3 50 separator 0.9539331 ¶ 2737 2739 W3119612974.pdf 3 0 text 0.9777593 "89 The target sample size was calculated according to the recommendation of 5 –10 observed values 90 per studied variable19. In this study, there were 14 variables, and the expected sample size was 91 140 (14 × 10). The study was conducted with the approval of the Ethics Committee of Southern 92 Medical University (Ref ID: NFYKDX002)." 0 345 W4317721949.pdf 5 1 separator 0.9950186 ¶ 345 347 W4317721949.pdf 5 2 title 0.98313427 93 Patient and public involvement 347 381 W4317721949.pdf 5 3 separator 0.99079686 ¶ 381 383 W4317721949.pdf 5 4 text 0.98711187 "94 The participants and the general public were not involved in the design, recruitment, and 95 conduction of this study." 383 508 W4317721949.pdf 5 5 separator 0.9964297 ¶ 508 510 W4317721949.pdf 5 6 title 0.9904563 96 Calculation of anxiety scores 510 543 W4317721949.pdf 5 7 separator 0.99221754 ¶ 543 545 W4317721949.pdf 5 8 text 0.9905078 "97 The Chinese version of the Generalized Anxiety Disorder Scale-7 (GAD-7)—a valid self- 98 reported psychometric scale—was used to measure individuals’ anxiety levels in the past two 99 weeks during COVID-19. The questionnaire comprised seven items using a 4-point Likert scale 100 ranging from 0 (not at all) to 3 (nearly every day), with a total score between 0–2120 21. The 101 levels of anxiety were classified as follows: normal (0–5), mild (5–9), moderate (10–14), and 102 severe (15–21)22. In a previous study23, a total score higher than 5 was deemed as anxiety. This 103 instrument has been widely used in China and also been confirmed to have good retesting 104 reliability and validity24 25. Similarly, in this study, the reliability was found to be very good 105 (Cronbach’s alpha = 0.94)." 545 1371 W4317721949.pdf 5 9 separator 0.9962386 ¶ 1371 1373 W4317721949.pdf 5 10 title 0.9876664 106 Covariates for analysis 1373 1401 W4317721949.pdf 5 11 separator 0.9910232 ¶ 1401 1403 W4317721949.pdf 5 12 text 0.9978114 "107 Socio-demographic variables in the analysis included sex, age, marital status, famil y registration, 108 educational attainment, occupational background, and annual family income. In addition, the 109 following health status data were collected and included: (1) good self-reported heal th (yes/no)" 1403 1712 W4317721949.pdf 5 13 separator 0.9729505 ¶ 1713 1715 W4317721949.pdf 5 14 paratext 0.9861377 PeerJ reviewing PDF | (2022:03:71827:4:0:NEW 13 Nov 2022) 1715 1773 W4317721949.pdf 5 15 separator 0.75583375 ¶ 1773 1775 W4317721949.pdf 5 16 paratext 0.9411652 Manuscripttobereviewed 1775 1798 W4317721949.pdf 5 0 paratext 0.92505276 "Publish with BioMed Central and every scientist can read your work free of charge" 0 87 W1995487684.pdf 1 1 separator 0.9753672 ¶ 87 89 W1995487684.pdf 1 2 text 0.9084091 """BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime.""" 89 220 W1995487684.pdf 1 3 separator 0.7312392 ¶ 220 222 W1995487684.pdf 1 4 contact 0.49408987 Sir Paul 222 232 W1995487684.pdf 1 5 text 0.51230925 Nurse 232 237 W1995487684.pdf 1 6 contact 0.58089375 , 237 238 W1995487684.pdf 1 7 text 0.438029 Cancer 238 245 W1995487684.pdf 1 8 contact 0.4710496 Research UK 245 257 W1995487684.pdf 1 9 separator 0.95431185 ¶ 257 259 W1995487684.pdf 1 10 text 0.806065 "Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright" 259 492 W1995487684.pdf 1 11 separator 0.89949286 ¶ 492 494 W1995487684.pdf 1 12 contact 0.4075433 Submit your m 494 508 W1995487684.pdf 1 13 paratext 0.37760141 anuscript 508 517 W1995487684.pdf 1 14 contact 0.4157251 here: 517 523 W1995487684.pdf 1 15 separator 0.31135243 523 524 W1995487684.pdf 1 16 paratext 0.31550848 ¶ 524 525 W1995487684.pdf 1 17 contact 0.4131609 http://www 525 536 W1995487684.pdf 1 18 paratext 0.54075015 . 536 537 W1995487684.pdf 1 19 contact 0.46144265 biomedcentral.com/info/publishing_ 537 571 W1995487684.pdf 1 20 paratext 0.4301578 adv 571 574 W1995487684.pdf 1 21 contact 0.3974573 .asp 574 578 W1995487684.pdf 1 22 paratext 0.98452115 BioMed centralBMC Pharmacology 2009, 9(Suppl 1):P19 http://www.biomed central.com/1471-2210/9/S1/P19 578 679 W1995487684.pdf 1 23 separator 0.8768227 ¶ 679 681 W1995487684.pdf 1 24 paratext 0.99087155 Page 2 of 2 681 693 W1995487684.pdf 1 25 separator 0.9959881 ¶ 693 695 W1995487684.pdf 1 26 text 0.6896595 "(page number not for citation purposes)relative expression and 1.8 ± 0.4 TIMP1-relative expres- sion, p < 0.05)." 695 810 W1995487684.pdf 1 27 separator 0.9809121 ¶ 810 812 W1995487684.pdf 1 28 title 0.8931886 Conclusion 812 823 W1995487684.pdf 1 29 separator 0.9873946 ¶ 823 825 W1995487684.pdf 1 30 text 0.9975692 "The present study shows that in a model with hyperten- sion and impaired renal function 1) aortic hypertrophyand remodelling is significantly more severe in male gen- der and 2) enhancing NO/GMP signalling by Bay 41-8543 ameliorates aortic wall changes significantly and in ablood pressure-independent manner." 825 1141 W1995487684.pdf 1 0 title 0.9796774 Table 2.Baseline characte ristics oftheGraz cohortÐ Distribution overall and byVTE status. 0 90 W2986596926.pdf 4 1 separator 0.9932068 ¶ 90 92 W2986596926.pdf 4 2 title 0.7206132 Variable Subject swith 92 115 W2986596926.pdf 4 3 table 0.9590251 "available data {%missin g}Overall Graz cohort (n=657)VTE during follow-up (n=34)NoVTE during follow-up (n=623)P* Demogr" 115 245 W2986596926.pdf 4 4 title 0.49158713 ap 245 248 W2986596926.pdf 4 5 table 0.98906004 "hic character istics Age, years 657 {0.0%} 35.9 [29.2±43.0] 36.5 [27.7±40.1] 35.7 [29.2±43.1] 0.5 BMI, kg/m 634 {3.5%} 24.7 [22.8±27.2] 23.9 [21.8±26.3] 24.8 [22.9±27.4] 0.11 Family history ofTGCT** 463 {29.5%} 17(3.7%) 0(0.0%) 17(3.8%) 0.39 Smoker orEx-Smoker 555 {15.5%} 281 (50.6%) 11(50.0%) 270 (50.7%) 0.95 Karnofsky Index<100% 647 {1.5%} 66(10.2%) 10(30.3%) 56(9.1%) <0.0001" 248 640 W2986596926.pdf 4 6 separator 0.5689776 ¶ 640 642 W2986596926.pdf 4 7 table 0.9930722 "Clinicopa thological variable s Non-Semin omatous histology648 {1.4%} 260 (40.1%) 22(66.7%) 238 (38.7%) 0.001 Clinical tumor stage 640 {2.6%} <0.0001 stage IA-IB 463 (72.3%) 10(2.2%) 453 (97.8%) stage IS 9(1.4%) 1(11.1%) 8(88.9%) stage IIA±IIC 98(15.3%) 8(8.2%) 90(91.8%) stage IIIA±IIIC 70(10.9%) 15(21.4%) 55(78.6%) RPLN(>5 cm) 652 {0.8%} 50(7.7%) 11(22.0%) 39(78.0%) <0.0001 IGCCCG riskstrati®cati on 180 {0.0%} 0.004 Good risk 137 (76.1%) 13(9.5%) 124 (90.5%) Intermediat erisk 19(10.6%) 7(36.8%) 12(63.2%) Poor risk 24(13.3%) 4(16.7%) 20(83.3) Chemothe rapy cycles 653 {0.6%} <0.0001 0cycles 367 (56.2%) 4(1.1%) 363 (98.9%) 1cycle 37(5.7%) 0(0.0%) 37(100%) 2cycles 91(13.9%) 6(6.6%) 85(93.4%) 3cycles 105 (16.1%) 10(9.5%) 95(90.5%) 4cycles 53(8.1%) 14(26.4%) 39(73.6%)" 642 1455 W2986596926.pdf 4 8 separator 0.7992625 ¶ 1455 1457 W2986596926.pdf 4 9 table 0.9917492 "Laborato ryparamete rs Hemoglob in,g/dL (13- 17.5)464 15.4 [14.7 1±16.2] 15.6 [14.6±16.1] 15.4 [14.7±16.2] 0.93 WBC, G/L(4.4±11.3) 461 7.7[6.2±9.5] 8.2[6.0±9.3] 7.7[6.2±9.5] 0.93 Platelet count, G/L(140± 440)461 231 [199±2 73] 226 [191±2 74] 232 [201±273] 0.59 CRP, mg/L (5) 427 1.8[1.0±7.7] 6.7[2.4±51.0] 1.8[1.0±6.3] 0.004 Fibrinoge n,mg/dL (210 ± 400)405 313 [250±4 25] 410 [324±6 53] 309 [249±418] 0.003 Tumor markers Preoperative AFP, ng/ mL(15)581 5.2[3.0±12.0] 14.0 [3.3±517.7] 5.0[3.0±10.1] 0.008 Preoperative betaHCG, mU/mL (5)592 5.0[2.0±11.2] 6.1[2.0±48.5] 5.0[2.0±9.4] 0.12 Preoperative LDH, U/L (120-240)474 216 [178±2 95] 343 [237±8 00] 212 [175±283] <0.0001 Khorana Score 586 0.002 Score =1 502 (85.7%) 20(4.0%) 482 (96.0%) Score =2 75(12.8%) 10(13.3%) 65(86.7%) Score =3 9(1.5%) 0(0.0%) 9(100%)" 1457 2309 W2986596926.pdf 4 10 separator 0.7227987 ¶ 2309 2311 W2986596926.pdf 4 11 table 0.9385949 "Follow-up data Recurrence ofcancer 657 {0.0%} 63(9.6%) 10(29.4%) 53(8.5%) <0.0001 (Continue d) Testicular cancer andthromboem bolism" 2311 2450 W2986596926.pdf 4 12 separator 0.8911618 ¶ 2450 2452 W2986596926.pdf 4 13 paratext 0.8446329 PLOS ONE |https://doi.or g/10.137 1/journal.po ne.01762 83 April 21,2017 5/15 2452 2530 W2986596926.pdf 4 0 paratext 0.96619684 10 0 2 W4385492667.pdf 9 1 title 0.9804934 "5.1. Analysis of the Metaverse is an Internet virtual world in the context of Web Content Accessibility Guidelines (WCAG) 2.2" 2 131 W4385492667.pdf 9 2 separator 0.99109805 ¶ 133 135 W4385492667.pdf 9 3 text 0.99915045 "This section emphasises the importance considering WCAG 2.2 compliance in the Metaverse context, because the Metaverse is an online virtual environment. The EU, UK, and US, have put in place legal frameworks to encourage accessibility and inclusivity, but WCAG 2.2 is especially relevant for accessibility and inclusiveness of disabled users and content creators ." 135 510 W4385492667.pdf 9 4 separator 0.956128 ¶ 511 513 W4385492667.pdf 9 5 text 0.99908614 "The Web Accessibility Directive (2016/2102) in the European Union outlines the accessibility criteria for websites and mobile applications in the pu blic sector. It encourages member states to implement accessibility measures in various digital services, including virtual environments, and is compliant with WCAG 2.1 Level AA. Adherence to the WCAG recommendations, especially version 2.2, would show the EU's commitment to accessibility." 513 965 W4385492667.pdf 9 6 separator 0.9592281 ¶ 967 969 W4385492667.pdf 9 7 text 0.99894816 "The Equality Act 2010 in the UK prohibits discrimination based on a person's disability and mandates that service providers make reasonable modifications to guarantee equal access. The WCAG 2.1 Level AA standard for acces sibility has been embraced by the UK government as well. It would be easier to fulfil legal requirements and improve accessibility for impaired users and content providers in the Metaverse by ensuring compliance with WCAG 2.2." 969 1430 W4385492667.pdf 9 8 separator 0.9643586 ¶ 1432 1434 W4385492667.pdf 9 9 text 0.9995034 "The Americans with Disabiliti es Act (ADA) of 1990, which mandates reasonable accommodations for people with disabilities, is applicable to virtual platforms in the United States. Although there is no formal federal statute requiring WCAG compliance, the ADA's duties have been interpre ted in a number of court cases to include digital accessibility. The de facto norm is WCAG 2.0 Level AA, and adoption of the most recent version, WCAG 2.2, would show a commitment to accessibility and lessen the likelihood of legal issues." 1434 1976 W4385492667.pdf 9 10 separator 0.95728207 ¶ 1978 1980 W4385492667.pdf 9 11 text 0.99922514 "Integrating WCAG 2.2 compliance into the creation and continuing management of the Metaverse is essential for the legal requirements in the EU, UK, and US. It would guarantee that people with disabilities may fully engage in virtual experiences and give content producers the tools they need to create inclusive and accessible content. Additionally, adhering to these rules and recommendations supports an inclusive culture and equal chances for everyone, regardless of disability, in the quickly changing environment of modern information and communication technology." 1980 2566 W4385492667.pdf 9 12 separator 0.9966215 ¶ 2568 2570 W4385492667.pdf 9 13 title 0.98383236 6. Results 2570 2581 W4385492667.pdf 9 14 separator 0.99549097 ¶ 2583 2585 W4385492667.pdf 9 15 text 0.9989573 "We summarise the key findings in a new framework for supporting, enabling, and encouraging physically disabled creative and performing artists to participate and build creative communities based on shared values. The framework is targeted at configuring a Metaverse that can be accessible/usable/inclusive for people with disabilities —via the associated physical and cognitive technologies and devices." 2585 3002 W4385492667.pdf 9 16 separator 0.95120806 ¶ ¶ 3004 3010 W4385492667.pdf 9 17 paratext 0.9773778 https://doi.org/10.33774/coe-2023-mwg81 ORCID: https://orcid.org/0000-0001-5629-6857 Content not peer-reviewed by Cambridge University Press. License: CC BY 4.0 3010 3176 W4385492667.pdf 9 0 paratext 0.9882125 Galley Proof 26/03/2010; 15:11 File: ica336.tex; BOKCTP/wyn p. 8 0 64 W1592208007.pdf 7 1 separator 0.9557106 ¶ 64 66 W1592208007.pdf 7 2 paratext 0.83166456 8 I. Mart et al. / 66 85 W1592208007.pdf 7 3 title 0.98758924 A multi-agent system for managing adverse weather situations on the road network 85 166 W1592208007.pdf 7 4 separator 0.99671096 ¶ 166 168 W1592208007.pdf 7 5 caption 0.9939658 Fig. 3. Example of the graphic interface. A segment of the Spanish A-3 road network from Madrid to Valencia is showed. 168 287 W1592208007.pdf 7 6 separator 0.9925889 ¶ 287 289 W1592208007.pdf 7 7 caption 0.9847823 "Fig. 4. A part of the road network used to evaluate the MAS prototype. In this case, there are two local systems with one VMS and one MS, connected to the TCC." 289 451 W1592208007.pdf 7 8 separator 0.9631114 ¶ 451 453 W1592208007.pdf 7 9 text 0.9984233 "controlling two main roads. The system has been test- ed in several situations: a) in a coordinated way, where all local systems and the TCSs provide a generic solu- tion, b) one local system works autonomously and the rest works coordinately; and c) all local systems work autonomously.In order to run the simulations, data provided by me- teorological stations have been reproduced using real files. Furthermore, specific weather incidences were simulates to test new adverse conditions" 453 956 W1592208007.pdf 7 10 separator 0.9948161 ¶ 956 958 W1592208007.pdf 7 11 caption 0.5561706 Figure 4 shows 958 973 W1592208007.pdf 7 12 text 0.5249155 973 974 W1592208007.pdf 7 13 caption 0.61986077 a part of the road network used to 974 1009 W1592208007.pdf 7 14 text 0.41376492 ¶ 1009 1010 W1592208007.pdf 7 15 caption 0.56360066 evaluate the MAS prototype. 1010 1038 W1592208007.pdf 7 16 text 0.57268476 In this 1038 1046 W1592208007.pdf 7 17 caption 0.49803266 case 1046 1051 W1592208007.pdf 7 18 text 0.5629255 , there are 1051 1062 W1592208007.pdf 7 19 caption 0.5117799 two 1062 1066 W1592208007.pdf 7 0 paratext 0.9904995 Cancers 2021 ,13, 2047 8 of 14 0 30 W3158910355.pdf 7 1 separator 0.99346864 ¶ 30 32 W3158910355.pdf 7 2 title 0.98598075 "3.2. Impact of Implementation of SelectMDx Versus PSAD into the mpMRI Pathway to Select Patients Candidate for Prostate Biopsy" 32 161 W3158910355.pdf 7 3 separator 0.98954177 ¶ 161 163 W3158910355.pdf 7 4 text 0.99971366 "The distribution of SelectMDx scores according to PI-RADS findings in mpMRI is reported in Figure 1b and compared to those for total PSA in Figure S1b. Interestingly, SelectMDx positivity increased from 30.3% for PI-RADS 1–2 cases, to 66.7% and 69.2% for PI-RADS 3 and 4–5 cases ( p< 0.01); additionally, total PSA values were differently distributed among PI-RADS score groups ( p< 0.01) (Figure 1b and Figure S1b). With regards to PI-RADS 3 lesions, 59.3% (32/54) showed PCa at biopsy, and 14 (25.9%) were csPCa; SelectMDx score was positive in 81.3% of PI-RADS score 3 associated with PCa diagnosis and positive in 45.4% of those negative for PCa at biopsy. In PI-RADS 4–5 lesions, SelectMDx score was positive in 88.9% of PCa cases, and in 25.0% of those with no PCa at biopsy." 163 962 W3158910355.pdf 7 5 separator 0.9467423 ¶ 962 964 W3158910355.pdf 7 6 text 0.99957836 "Cases with discordant tests were investigated to analyze the potential added value of implementing SelectMDx in the mpMRI diagnostic pathway. If we look at PI-RADS 1–2 cases, according to SelectMDx results, 30.3% (54/178) of patients would undergo biopsy with the detection of 16 (15.4%) PCa and 8 (12.9%) csPCa. Avoiding biopsy in patients with a PI-RADS score 4–5 and a negative SelecMDx test would result in 24 (30.8%) being spared biopsies within this category, while missing 6 (5.8%) PCa and 4 (6.5%) csPC. Regarding PI-RADS 3 cases, performing prostate biopsy only in those with a positive SelectMDx would result in 81.3% (26/32) of PCa detected, while avoiding biopsy in those with a negative SelectMDx would result in 18.8% (6/32) of PCa and 14.3% (2/14) of csPCa missed." 964 1760 W3158910355.pdf 7 7 separator 0.95000386 ¶ 1760 1762 W3158910355.pdf 7 8 text 0.99960333 "Performing prostate biopsy in patients with a PI-RADS score 1–2 and PSAD 0.15, would result in 48/178 (27.0%) biopsies performed in this category, with the detection of 6 (5.8%) PCa and 4 (6.5%) csPC. Avoiding biopsy in patients with a PI-RADS score 4–5 and PSAD < 0.15, would result in 28 (35.9%) spared biopsies within this category, yet missing 14 (13.5%) PCa and 10 (16.1%) csPC. If we perform prostate biopsy among PI-RADS score 3 cases only in those with PSAD 0.15, this would result in the detection of 8/32 (25.0%) PCa and 4/14 (28.6%) csPCa, while avoiding biopsy in those with PSAD < 0.15 would miss 24/32 (75.5%) PCa and 10/14 (71.4%) csPCa diagnosed within this category." 1762 2462 W3158910355.pdf 7 9 separator 0.9973656 ¶ 2462 2464 W3158910355.pdf 7 10 title 0.9943355 3.3. Impact of Different Screening Strategies to Select Patients Candidate for Prostate Biopsy 2464 2559 W3158910355.pdf 7 11 separator 0.9959465 ¶ 2559 2561 W3158910355.pdf 7 12 text 0.9996831 "Several strategies of combining and sequencing SelectMDx and mpMRI have been simulated to investigate their impact in terms of number of avoided biopsies, missed PCa and csPCa (Table 3). Limiting biopsy to men with a positive SelectMDx would result in avoiding 53.5% (166/310) of biopsies, while missing 13.5% (14/104) of PCa and 12.9% (8/62) of csPCa; performing a biopsy only in those men with a positive mpMRI (PI-RADS 4–5) would avoid 74.8% (232/310) of biopsies and miss 48.1% (50/104) of PCa and 38.7% (24/62) of csPCa. Initial SelectMDx test followed by mpMRI if the test was positive and a subsequent biopsy if the mpMRI showed PI-RADS 4–5 findings, would result in 82.6% (256/310) of biopsies avoided, yet with 53.9% (116/104) of PCa and 45.2% (28/62) of csPCa missed. Initial mpMRI followed by biopsy for positive mpMRI cases (PI-RADS 4–5) and negative mpMRI cases (PI-RADS 1–3) (only if SelectMDx was positive), would result in avoiding 45.8% (142/310) of biopsies, while only missing 7.7% (8/104) of PCa and 6.5% (6/62) of csPCa." 2561 3626 W3158910355.pdf 7 0 paratext 0.9840678 fpsyg-13-774165 May 16, 2022 Time: 14:24 # 6 0 44 W4280629697.pdf 5 1 separator 0.9867233 ¶ 44 46 W4280629697.pdf 5 2 text 0.9821919 "Fareed et al. Human Resource Professionals Effectiveness Model were apprehended by interpreting the interview tapes (MP3) into the interview transcripts. As stated earlier, each interview acquired about forty to sixty, consequently, interpreting the interview tapes (MP3) into the interview transcriptions took more than 2 weeks and more than 50 pages. After interviews were transcribed, content analysis has been recognized as an appropriate technique for analyzing the interview transcripts. And identification of the key themes and dimensions has been assembled by the way of detaining and getting the relevant elements and concepts of each variable from each participant." 46 741 W4280629697.pdf 5 3 separator 0.89439476 ¶ 741 743 W4280629697.pdf 5 4 text 0.9996579 "Content analysis was carried out on two stages “first-order and second-order” (Gehman et al., 2017). The first stage acts upon single-interview transcripts for identification of the concepts and key terms (first-order codes), whereas the second (2nd) stage acts upon cross interview transcripts for the validation of the concepts (second-order themes), which, in-depth, analyzes the similarities and differences of the factors and elements. Once all the first- order codes and second-order themes and dimensions have been accumulated, then we have the foundation of building a data structure. This, perhaps, is the most essential step in the entire research approach because it shows the progression from raw data to first-order codes to second-order theoretical themes and dimensions, which is an important part of demonstrating rigor in qualitative research. First-order and second-order terminologies seem to become progressively predominant in recent years in the qualitative field research (Gehman et al., 2017). Content analysis was done manually, and inductive as well as deductive reasoning was applied to classify the factors and elements. Therefore, the mapping of findings was done through a combination of inductive and deductive approaches of content analysis." 743 2046 W4280629697.pdf 5 5 separator 0.9890862 ¶ 2046 2048 W4280629697.pdf 5 6 title 0.98970634 FINDINGS AND DISCUSSION 2048 2072 W4280629697.pdf 5 7 separator 0.99204576 ¶ 2072 2074 W4280629697.pdf 5 8 text 0.99228776 "Data were collected from HR executives of Telco firms (Mobilink, Telenor, Zong, Ufone and Warid) through semi-structured interviews. These Telco firms are the top firms in Pakistan as per their market shares and subscribers. They hold 99% of the market share in the Telco industry as per the PTA (2013–2012). The researchers interviewed two HR managers/executives, each from Telenor, Mobilink, and Zong, while three from Ufone and" 2074 2514 W4280629697.pdf 5 9 separator 0.970328 ¶ 2514 2516 W4280629697.pdf 5 10 title 0.9193439 TABLE 1 | Demographic information of the participants. 2516 2571 W4280629697.pdf 5 11 separator 0.9025936 ¶ 2571 2573 W4280629697.pdf 5 12 table 0.96987695 "Participants Company Current PositionWorking ExperienceHighest Qualification 1 Telenor HR Executive 11 years MBA (HR) 2 Ufone HR Executive 5 years MBA (HR) 3 Zong HR Executive 8 years MBA (HR) 4 Mobilink HR Executive 6 years MBA (HR) 5 Warid HR Operations Executive6 years MBA (HR) 6 Zong HR Executive 6 years MBA (HR) 7 Mobilink HR Executive 7 years MBA (HR) 8 Ufone HR Manager 5 years MBA (HR) 9 Telenor HR Director 6 and half years MBA (HR) 10 Ufone Manager (OD) 5 years MSC (HR)one" 2573 3086 W4280629697.pdf 5 13 text 0.98998755 "from Warid. This is due to, during the field study, Mobilink was in the process of consolidating Warid, which was officially publicized far along in PTA Annual Report (2016). Nonetheless, it was challenging to approach another HR executive from Warid; for that reason, the HR executive from Ufone was approached and providentially obtainable for the field interview. The aim behind was to exactly point out the experiences related to the performance of HR managers itself. Supporting the argument, Ahmad et al. (2014) encouraged forthcoming scholars to study HR managers in measuring HR professionals’ effectiveness." 3086 3716 W4280629697.pdf 5 14 separator 0.97285616 ¶ 3716 3718 W4280629697.pdf 5 15 text 0.9980662 "Table 1 specifies that the total number of HR professionals who were the part of qualitative field research is ten participants. Among which seven participants are HR executives, and one each participant is an HR manager, a manager of organization development (OD) and an HR director. All HR professionals have sufficient experience in the field of HR, which facilitated researchers to get thoughtful information and to gain insight into their experiences in the workplace. The HR professionals also had earlier worked in the HR domain prior to they had been employed by the current organization. The HR professionals have been recognized by their organizations to key HR positions after certain years of working experience and training. All of the ten HR professionals have completed their Master of Business Administration specialized in the human resources area. The HR professionals’ experiences and their qualifications symbolize that they are appropriate for the field interviews; therefore, they were reliable for the qualitative field research." 3718 4795 W4280629697.pdf 5 16 separator 0.98532414 ¶ 4795 4797 W4280629697.pdf 5 17 text 0.9992375 "Table 2 presents the insights of the participants into their levels of effectiveness in nine key strategic functions, which they perceive are essentials to execute if they want to be effective. Nevertheless, it has been affirmed that the level of HR professionals’ effectiveness is above the standards as their responses reveal higher proportions in all nine key strategic functions. These key strategic functions are expressed in below Table 2 , accompanied by the level of effectiveness." 4797 5295 W4280629697.pdf 5 18 separator 0.99539423 ¶ 5295 5297 W4280629697.pdf 5 19 text 0.99172693 "The fable displays the level of HR professionals’ effectiveness and highlights the core strategic functions, which drive the effectiveness of HR professionals. Columns of the table illustrate the level of effectiveness in percentages, while rows represent the nine strategic functions, which HR professionals are obligatory to perform for the purpose of expanding their effectiveness. These strategic functions are recruitment of right candidates at the right time, responding to employees’ needs and demands, communicating timely information, developing HR policies and procedures, performing optimum HR practices, HR professionals’ roles, HR professionals’ responsibilities, providing career plans and providing support and services for the employees. Besides this, the level of effectiveness was established by the measurement of the average score (in percentage) given by each participant in every strategic function, whereas the average score was calculated as the total score divided by nine strategic functions (see Table 2 ). It is believed that there is no pragmatic approach or criterion available in previous research, which can lead us to understand the standards on the level of HR professionals’ effectiveness by following what we can postulate, that the level of effectiveness is higher or not. This is since previous researchers (Wright et al., 2001b; Han et al., 2006; Choi" 5297 6723 W4280629697.pdf 5 20 separator 0.7351854 ¶ 6723 6725 W4280629697.pdf 5 21 paratext 0.98334265 Frontiers in Psychology | www.frontiersin.org 6 May 2022 | Volume 13 | Article 774165 6725 6811 W4280629697.pdf 5 0 text 0.9995866 "expressing ’, metastatically potent cells. This also carries the possibility of a primary tumour showing relatively higher expression levels than its metastasis, which wouldhave already been re-selected by the new microenviron- ment. Translating this into clinical practice would mean, that the ‘lack ’of overexpression would not exclude metastatic potential or even a worse prognosis. As pri- mary tumour site seemed to be interesting in terms of selection of metastatically potent, CD44v3/v6 high sub-clones, we tried to find support os this theory in another, quite different model system." 0 608 W2110600317.pdf 9 1 separator 0.9749805 ¶ 608 610 W2110600317.pdf 9 2 text 0.9996684 "We further examined the role of the primary tumour microenvironment in our subcutaneously implanted xenograft model. CD44v3 and v6 expression levels were different in tumours implanted from the same cell sus-pension, into genetically identical host, i.e. newborn and adult scid mice, which were only physiologically differ- ent. Hence, differences in expression levels of the exam-ined gene products (v3 and v6) could be correlated with differences in metastatic potential (0% vs. 100%). Micro- environmental (host) factors (such as maturity immunesystem, vascular permeability, cytokines and chemo- kines, etc.) should, therefore, stand as driving factors in the background of metastatically potent subclones whichwill ultimately determine the clinical behaviour of the entire tumour. These experiments prove that physio- logical factors of host (as well as primary tumour micro-environment) do matter and in extreme, experimental conditions can fully determine metastatic potential of a malignant system." 610 1643 W2110600317.pdf 9 3 separator 0.9958227 ¶ 1643 1645 W2110600317.pdf 9 4 title 0.984845 Conclusions 1645 1657 W2110600317.pdf 9 5 separator 0.9937383 ¶ 1657 1659 W2110600317.pdf 9 6 text 0.9963935 "It is likely to assume that tumour microenvironment(tumour host organism) have a central role in metastatic phenotype presentation of primary colorectal cancer. While normal tissues (such as colonic mucosa) do not express variant isoforms of CD44, tumours seem to per- form a wide variation of CD44 isoforms. Presuming that different domains of different CD44 isoforms can performa variety of new functions, there is no more sense in investigating CD44 “in general ”." 1659 2139 W2110600317.pdf 9 7 separator 0.65542436 ¶ 2139 2141 W2110600317.pdf 9 8 text 0.9996326 "Moreover, expression pattern of CD44 isoforms was found to be stable , meaning that colorectal type expression profile remained unchanged from tumour cell suspen- sions (in vitro) throughout primary and metastatic colon cancer xenografts. In contrary, quantitative changes do exist in the expression of distinct variant exons." 2141 2478 W2110600317.pdf 9 9 separator 0.967734 ¶ 2478 2480 W2110600317.pdf 9 10 text 0.9996597 "CD44 variant isoforms, especially the functionally well-characterized v3 and v6 containing isoforms, seem to massively take part in expressing the metastatic phenotype . Our results support that higher-level v3/v6 co-expression can represent this “quasy-metastatic-gene ” function at the primary tumour site and at the early phase of the metastatic cascade. Nontheless, it must beemphasized that only a minor proportion of the primary tumour mass is sufficient to hold “metastatic-phenotype ” for the complete primary tumour. Although each colo-rectal tumour types use metastatic subclones of high CD44v3/v6 expression rate, selective examination of metastatic tumour cell group is not yet resolved. Thismeans that quantitative evaluation of not only CD44 “in general ”, but even of v3/v6-containing isoforms are inappropriate for the prognosis of metastatic behaviorof a single tumour case because of the summative way of the measurement techniques. Moreover this can be the background of the quite diversive results on the pre-dictive value of “CD44 ”in the literature." 2480 3580 W2110600317.pdf 9 11 separator 0.9971395 ¶ 3580 3582 W2110600317.pdf 9 12 title 0.9899643 Methods 3582 3590 W2110600317.pdf 9 13 separator 0.9875732 ¶ 3590 3592 W2110600317.pdf 9 14 title 0.97870064 Tumour cell cultures 3592 3613 W2110600317.pdf 9 15 separator 0.9887157 ¶ 3613 3615 W2110600317.pdf 9 16 text 0.9984598 "We maintained cell cultures of three genetically different human colorectal cell lines (HT25 (from M.Hendricks,Iowa), HT29 (ECACC 91072201) and HCT116 (ICLC HTL95025)), four other human neoplastic cell lines (MCF7 –human breast cancer cell line (ATCC HTB-22 TM), K562 –chronic myelogenous leukemia cell line (ATCC CCL-243TM), A431 –human vulvar epidermoid carcinoma cell line (ATCC CRL 1555), HT199 –human malignant melanoma cell line (developed in the 1st Department of Pathology and Experimental Cancer Research (Semmel- weis University, Budapest, Hungary)) and a mouse colo-rectal cell line (C26 - derived from BALB/C Colon26 murine colon adenocarcinoma - obtained from ATCC. USA) in 5% FCS and 1% Penicillin/Streptomycin con-taining 1640-RPMI medium at 37°C. For implantation we prepared single-cell suspensions after enzymatic (Tripsine- E D T A )d i g e s t i o na n dw a s h e dt h ec u l t u r e st w i c ew i t hF C S -free medium." 3615 4582 W2110600317.pdf 9 17 separator 0.996926 ¶ 4582 4584 W2110600317.pdf 9 18 title 0.98910075 In vivo experimental models 4584 4612 W2110600317.pdf 9 19 separator 0.8949263 ¶ 4612 4614 W2110600317.pdf 9 20 title 0.9588331 Isograft model 4614 4629 W2110600317.pdf 9 21 separator 0.9883009 ¶ 4629 4631 W2110600317.pdf 9 22 text 0.99826473 "We injected suspensions of C26 isograft colorectal tumour cell line into the spleen (4 animals) [80]andcolonic wall (4 animals) of adult (20-week-old, 20g – weigh) Balb-C mice. Anaesthesia was performed by intraperitoneal injection of Nembuthal (70 mg/kg). Eachtumour injection was performed by 0.05 ml suspension of 5x10 5cells (107cell/ml serum-free one-cell suspen- sions). After 4 weeks, animals were sacrificed, autopsywas performed and tumour tissues of primary tumours and liver metastases were isolated Figure" 4631 5163 W2110600317.pdf 9 23 caption 0.88876176 5I.a,I.b. 5163 5173 W2110600317.pdf 9 24 separator 0.9620743 ¶ 5173 5175 W2110600317.pdf 9 25 caption 0.9913925 "Human xenograft model I. - spontaneous lung metastatic model from heterotopic (subcutaneous) implantation" 5175 5283 W2110600317.pdf 9 26 separator 0.62966895 ¶ 5283 5285 W2110600317.pdf 9 27 text 0.7921155 "Single cell suspension of HT25, HT29 and HCT116 cell lines (5x105cells / 0.05 ml) were subcutaneously implanted into adult and newborn scid mice into the same localization (left lumbar region) using the same" 5285 5499 W2110600317.pdf 9 28 paratext 0.9524706 "Bánky et al. Molecular Cancer 2012, 11:83 Page 10 of 15 http://www.molecular-cancer.com/content/11/1/83" 5499 5604 W2110600317.pdf 9 0 title 0.97014016 ACKONWLEDGEMENTS 0 16 W2904932512.pdf 5 1 separator 0.9885558 ¶ 17 19 W2904932512.pdf 5 2 text 0.9519988 "This study was financially supported by Natural Science Foundation of China (Grant No. 51409015; 51679094; 51339001); the National Key Research and Development Program of China (Grant No. 2016YFC0402305 and 2016YFC0402310); and the Public Welfare Scientific Research Funding Project of the MWR of China (Grant No. 201401011)." 19 363 W2904932512.pdf 5 3 separator 0.99505603 ¶ 364 366 W2904932512.pdf 5 4 title 0.96985835 REFERENCES 366 377 W2904932512.pdf 5 5 separator 0.98570895 ¶ 378 380 W2904932512.pdf 5 6 bibliography 0.99762225 "1. C.A.C. Coello, Theoretical and numerical constraint- handling techniques used with evolutionary algorithms: a survey of the state of the art, Comput. Methods Appl. Mech. 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Computer Journal, (1965)308-313." 1580 1682 W2904932512.pdf 5 23 separator 0.88911533 ¶ 1683 1685 W2904932512.pdf 5 24 bibliography 0.9979586 "10. K.V . Price, R.M. Storn, Differential evolution - a simple evolution strategy for fast optimization. Dr. Dobb’s Journal, 22(1997)18-24." 1685 1831 W2904932512.pdf 5 25 separator 0.9325635 ¶ 1832 1834 W2904932512.pdf 5 26 bibliography 0.9979802 "11. K.V . Price, R.M. Storn, J.A. Lampinen, Differential Evolution: A Practical Approach to Global Optimization, Springer-Verlag, New York, 2005." 1834 1986 W2904932512.pdf 5 27 separator 0.91104007 ¶ 1987 1989 W2904932512.pdf 5 28 bibliography 0.99782145 "12. Michalewicz Z. Genetic Algorithms + Data Structures = Evolution Programs, Springer-Verlag, New York, 1996." 1989 2106 W2904932512.pdf 5 29 separator 0.94318736 ¶ 2107 2109 W2904932512.pdf 5 30 bibliography 0.99210477 "13. Ono I, Kita H, Kobayashi S. A robust real-coded genetic algorithm using unimodal normal distribution crossover augmented by uniform crossover: effects of self-adaptation of crossover probabilities. Proceedings of the Genetic and Evolutionary Computation Conference. San Mateo: Morgan Kaufmann Publishers, 1999, 496~503." 2109 2451 W2904932512.pdf 5 31 separator 0.9755633 ¶ 2453 2455 W2904932512.pdf 5 32 bibliography 0.99767935 "14. Price K, Strom R, Lampinen J. Differential evolution: a practical approach to global optimization [M]. Springer Science & Bu siness Media, 2006." 2455 2607 W2904932512.pdf 5 33 separator 0.95860946 ¶ 2608 2610 W2904932512.pdf 5 34 bibliography 0.9974192 "15. Shu-Kai S. Fan, Yun-Chia L i a n g , E r w i e Z a h a r a , A genetic algorithm and a particle swarm optimizer hybridized with Nelder– Mead simplex search. Computer and Industrial Engineering. 50(2006)401- 425." 2610 2842 W2904932512.pdf 5 35 separator 0.96107185 ¶ 2843 2845 W2904932512.pdf 5 36 bibliography 0.99785477 "16. S. Simonovic, The implicit stochastic model for reservoir yield optimization, Water Resour Res., 23(1987)2159-2165." 2845 2971 W2904932512.pdf 5 37 separator 0.9157264 ¶ 2972 2974 W2904932512.pdf 5 38 bibliography 0.99769974 "17. Storn R, Price K. Differential evolution–a simple and efficient heuristic for global optimization over continuous spaces [J]. Journal of global optimization, 1997, 11(4): 341-359." 2974 3167 W2904932512.pdf 5 39 separator 0.95298314 ¶ 3168 3170 W2904932512.pdf 5 40 bibliography 0.9978225 "18. Takahashi M, Kita H. A crossover operator using independent component analysis for real-coded genetic algorithm. Proceedings of the 2001 Congress on Evolutionary Computation, 2001, pp. 643-649." 3170 3377 W2904932512.pdf 5 41 separator 0.9538491 ¶ 3378 3380 W2904932512.pdf 5 42 bibliography 0.9976637 "19. Thangavelu S, Velayutham C S. An investigation on mixing heterogeneous differential evolution variants in a distributed framework [M]. Inderscience Publishers, 2015." 3380 3559 W2904932512.pdf 5 43 separator 0.95317745 ¶ 3560 3562 W2904932512.pdf 5 44 bibliography 0.99776435 "20. Tsutsui S, Yamamura M, Higuchi T. Multi-parent recombination with simplex crossover in real coded genetic algorithms. Proceedings of the Genetic and Evolutionary Computation Conference. San Mateo: Morgan Kaufmann Publishers, 1999. 657~664." 3562 3818 W2904932512.pdf 5 45 separator 0.9642071 ¶ 3819 3821 W2904932512.pdf 5 46 bibliography 0.9977186 "21. Wen X, Xia Q, Zhao Y . An effective genetic algorithm for circularity error unified evaluation [J]. International Journal of Machine Tools & Manufacture, 2006, 46(14):1770-1777." 3821 4012 W2904932512.pdf 5 47 separator 0.9671017 ¶ 4014 4016 W2904932512.pdf 5 48 bibliography 0.9980492 "22. W. Splendy, G.R. Hext, F.R. Himsworth Sequential application of simplex design in optimization and evolutionary design. Technometrics (1962) 441-461." 4016 4176 W2904932512.pdf 5 49 separator 0.9285663 ¶ 4177 4179 W2904932512.pdf 5 50 bibliography 0.99801546 "23. X. Liu, S. Guo, P. Liu, L. Chen, X. Li, Deriving optimal refill rules for multi-purpose reservoir operation, Water Resour Manage 25 (2011)431-448." 4179 4337 W2904932512.pdf 5 51 separator 0.9310137 ¶ 4338 4340 W2904932512.pdf 5 52 bibliography 0.9979425 "24. Yan X, Liu H, Zhu Z, et al. Hybrid genetic algorithm for engineering design problems [J]. Cluster Computing, 2016, 13(9):1-13." 4340 4478 W2904932512.pdf 5 53 separator 0.9506469 ¶ 4479 4481 W2904932512.pdf 5 54 bibliography 0.9977121 "25. Z. Michalewicz, Genetic Algorithms + Data Structures = Evolution Programs, Springer-Verlag, New York, 1996." 4481 4599 W2904932512.pdf 5 55 separator 0.9681948 ¶ ¶ 4601 4607 W2904932512.pdf 5 56 paratext 0.96691024 "6 ,0 (2018) MATEC Web of Conferences https://doi.org/10.1051/matecconf/201824601003 246 1003 ISWSO 2018" 4607 4721 W2904932512.pdf 5 0 paratext 0.98751265 http://ijsp.ccsenet.org International Journal of Statistics and Probability V ol. 10, No. 1; 2021 0 97 W3115197588.pdf 1 1 separator 0.9959865 ¶ 97 99 W3115197588.pdf 1 2 caption 0.975902 Figure 1. Xi=0:1+3i=100 for 1i30. The solid line is the unknown function fdefined by f(x)=1=xforx2(0;1) 99 206 W3115197588.pdf 1 3 separator 0.95727175 ¶ 206 208 W3115197588.pdf 1 4 text 0.7730295 "and the circles are the observations Yi=f(Xi)+""i, the dashed line is the convex regression estimator" 208 310 W3115197588.pdf 1 5 caption 0.90129614 ", and the dotted line is the penalized convex regression estimator with n=0:01. The""i’s follow iid standard normal distributions" 310 441 W3115197588.pdf 1 6 separator 0.99261296 ¶ 441 443 W3115197588.pdf 1 7 text 0.99934846 "We refer to the solution to (2) as the convex regression estimator, and this estimator has gained a great deal of attention from numerous researchers. Hanson and Pledger (1976) established consistency for the case when d=1, Groeneboom et al. (2001) computed the rate of convergence for the case when d=2, Seijo and Sen (2011) studies consistency for the case when d>1, and Mazumder et al. (2019) proposed an e cient algorithm for solving (2). One can note that (2) is a convex quadratic program with n(d+1) decision variables and n2linear constraints, so one can solve (2) by using convex programming solvers." 443 1064 W3115197588.pdf 1 8 separator 0.979071 ¶ 1064 1066 W3115197588.pdf 1 9 text 0.99952245 "One of the drawbacks of the convex regression estimator is that it tends to overfit the data set near the boundary of the domain, so its subgradient gets large near the boundary. The main reason of this undesirable situation is that (2) is formulated in a way that only the sum of squared errors is minimized. Thus, one way to remedy this situation is adding a penalty term to the objective function of (2), which leads to the following formulation:" 1066 1521 W3115197588.pdf 1 10 separator 0.9860453 ¶ 1521 1523 W3115197588.pdf 1 11 math 0.8177763 "Minimize1 nnX i=1(Yi" 1523 1548 W3115197588.pdf 1 0 title 0.9849493 Case presentation 0 17 W2131077930.pdf 1 1 separator 0.99471927 ¶ 17 19 W2131077930.pdf 1 2 text 0.9996406 "A 9-year-old Greek boy was transferred in the Emergency Department of the hospital after sustaining injuries by stray lead shots fired from a shotgun. On his admission the patient had a patent airway, Beats: 122 per minute, Blood Pressure: 135/60 mmHg, SpO2: 96% and Breaths: 30/min while from the full blood count Hb: 6.6 gm/dl, Hct: 17.2%. He had suffered multiple entry points by the lead shots that were distributed across the right side of his thorax, abdomen and left arm. On auscultation the patient had decreased lung sounds on the right side and subcutaneous emphysema. A chest tube was placed that confirmed the suspicion of pneumothorax and hemothorax. His abdomen was soft and tender with no sign of peritonitis engorgement or pain. A urine catheter was placed that revealed macroscopic hematuria. The patient was intubated and a computed tomography scanwas followed. The computed tomography scan of the thorax revealed lacerations of the lung parenchyma in the right middle and lower lobe, pneumothorax, free pleural fluid, large subcutaneous emphysema, small collection of fluid (blood) in the pericardium and multiple lead shots scattered inside the thoracic cavity and the thoracic wall." 19 1263 W2131077930.pdf 1 3 separator 0.95954424 ¶ 1263 1265 W2131077930.pdf 1 4 text 0.9992807 "No major injury to the heart (one lead shot was lodged between the epicardium and pericardium) or the large blood vessels was observed (Figure 1).In the abdominal cavity the computed tomography scan showed: extended lacerations of the liver (segments V, VI,VII, VIII,) and a fracture of segment V fracture of the lowerpole of the right kidney. The child was transferred in thepediatric intensive care unit of our hospital were he was transfused with blood products and remained hemody- namically stable during the critical initial period after theinjury. The continuous monitoring by clinical examina-tion and ultrasound of his abdominal cavity showed nochange and his clinical condition was stabilized in thepediatric intensive care unit with no further blood loss. Hecontinued to have a large quantity of fluid in his abdomenthat showed no sign of decreasing, on the contrary on the 8 thday of his hospitalization the child was transferred in the operating room for an exploratory surgery of theabdomen due to the progression of intra-abdominalinflammation caused by choloperitoneum and the verylarge amount of fluid collected. During the operation theperitoneal cavity was found to be filled with bile and onexploration of the billiary tree a small hole was found onthe wall of the gallbladder. His post-op hospitalization was normal with no complications. The manufacturers of the lead pellets for shotguns use lead and antimony aspropellants. Because of the large amount of lead pelletsinside the patient ’s body the blood lead levels were measured periodically [5]. He also developed a temporaryulnar nerve paresis which was developed by a pellet whichinjured the nerve." 1265 2964 W2131077930.pdf 1 5 separator 0.99713933 ¶ 2964 2966 W2131077930.pdf 1 6 title 0.98741674 Discussion 2966 2977 W2131077930.pdf 1 7 separator 0.9949355 ¶ 2977 2979 W2131077930.pdf 1 8 text 0.99971366 "The most commonly affected organs by penetrating firearm injury in children are the small bowel, colon, liver and stomach followed by the spleen, kidney and pancreas [3,6,7]. Anatomic differences between the body of children and adults may account for the higher incidence of multivisceral injuries in children with penetrating injury [6]. The thoracic cage in children is much more compliant and not as well developed therefore affording less protection to the liver and other organs. The viscera of children are smaller and in closer proximity to each other, and the hepatic mass is smaller providing less physical protection to adjacent organs than in adults. The injuries that are developed by the pellets can be fatal in some cases. The incidence of gunshots in children and adults is rising over time [1,8]. The existence of a pediatric intensive care unit is very crucial for the management of these patients. The appropriate co-operation of different medical specialities in such multi-injured patients can save the life of a child." 2979 4056 W2131077930.pdf 1 9 separator 0.9964602 ¶ 4056 4058 W2131077930.pdf 1 10 title 0.9799974 Conclusion 4058 4069 W2131077930.pdf 1 11 separator 0.9924885 ¶ 4069 4071 W2131077930.pdf 1 12 text 0.993251 "We feel that carefully selected patients can be treated conservatively under pediatric intensive care unit mon- itoring conditions having in mind that especially in " 4071 4241 W2131077930.pdf 1 13 separator 0.6446316 ¶ 4241 4242 W2131077930.pdf 1 14 caption 0.99614906 Figure 1. X-ray shows the pellets in the thorax and abdomen. 4242 4303 W2131077930.pdf 1 15 separator 0.97596526 ¶ 4303 4305 W2131077930.pdf 1 16 paratext 0.9903627 Page 2 of 3 4305 4317 W2131077930.pdf 1 17 separator 0.91256636 ¶ 4317 4319 W2131077930.pdf 1 18 paratext 0.9651179 (page number not for citation purposes)Cases Journal 2009, 2:6340 http://casesjournal.com/casesjournal/article/view/6340 4319 4440 W2131077930.pdf 1 0 paratext 0.9682547 4 93 0 5 W4223515558.pdf 4 1 separator 0.67635286 ¶ 6 8 W4223515558.pdf 4 2 paratext 0.7774556 94 9 12 W4223515558.pdf 4 3 separator 0.9903532 ¶ 13 15 W4223515558.pdf 4 4 caption 0.9882906 Fig. 1 . Cross -reactive SARS -CoV-2-specific T cells are present in pre -pandemic BAL 95 15 105 W4223515558.pdf 4 5 separator 0.72243524 ¶ 106 108 W4223515558.pdf 4 6 caption 0.9725736 samples: a,b, Frequency of TNF a (a) and IFNg-producing ( b) CD4+ (left) and CD8+ (right) T 96 108 206 W4223515558.pdf 4 7 separator 0.4393283 ¶ 206 207 W4223515558.pdf 4 8 caption 0.970982 cells in BAL for each peptide pool. Doughnut plots on top show per centage of samples abov e 97 207 303 W4223515558.pdf 4 9 separator 0.55173445 ¶ 304 306 W4223515558.pdf 4 10 caption 0.82966846 mean+2SD of DMSO control. c, Total Sars -CoV-2-specific CD4+ (left) and CD8+ (right) T cells 306 399 W4223515558.pdf 4 11 table 0.538055 98 ¶ 399 405 W4223515558.pdf 4 12 caption 0.5729521 producing T 405 417 W4223515558.pdf 4 13 table 0.49549744 NF a or IFNg. d 417 432 W4223515558.pdf 4 14 caption 0.5635663 , Individual responses of 432 457 W4223515558.pdf 4 15 table 0.5356848 "CD4+ or CD8+ T cells producing TNF a 99 (" 457 502 W4223515558.pdf 4 16 caption 0.51213837 left) or 502 511 W4223515558.pdf 4 17 table 0.5246956 IFN g 511 516 W4223515558.pdf 4 18 caption 0.56004184 (right) in BAL. 516 532 W4223515558.pdf 4 19 table 0.53369296 e 532 534 W4223515558.pdf 4 20 caption 0.5289824 , Correlation of total 534 556 W4223515558.pdf 4 21 table 0.5464449 TNF a 556 562 W4223515558.pdf 4 22 caption 0.47249717 (left 562 568 W4223515558.pdf 4 23 table 0.5094677 ) and IFN g (right) 568 587 W4223515558.pdf 4 24 caption 0.525164 -producing CD4+ 587 603 W4223515558.pdf 4 25 table 0.65614784 100 603 607 W4223515558.pdf 4 26 separator 0.38654533 ¶ 608 610 W4223515558.pdf 4 27 caption 0.84349126 vs. CD8+ T cells in BAL. a-d, bars at median; grey area represents mean+2SD of DMSO 101 610 700 W4223515558.pdf 4 28 separator 0.30702582 ¶ 700 701 W4223515558.pdf 4 29 caption 0.6709292 control. *p<0.05, **p<0.01, ***p<0.001; a,b, ANOVA and Dunn’s multiple comparison; c,d, 701 790 W4223515558.pdf 4 30 table 0.35041916 102 ¶ 790 797 W4223515558.pdf 4 31 caption 0.56706357 Wilcoxon; e, Spearman correlation. 797 832 W4223515558.pdf 4 32 table 0.469817 103 834 838 W4223515558.pdf 4 33 separator 0.9931493 ¶ 839 841 W4223515558.pdf 4 34 caption 0.32767913 Fig 841 845 W4223515558.pdf 4 35 title 0.42796928 . 845 846 W4223515558.pdf 4 36 table 0.37909007 1 846 848 W4223515558.pdf 4 37 separator 0.49419606 ¶ 850 852 W4223515558.pdf 4 38 table 0.95445937 "a b c 0 10 20 300.00.51.01.52.0% TNFα+ CD8+ % TNFα+ CD4+ r= 0.7234, * 0 1 2 3 40.00.51.01.5% IFNγ+ CD8+ % IFNγ+ CD4+ r= 0.8234, ** e Spike NSP7 NSP12 NSP13 Total Sars -CoV-2-specific response d TNFα IFNγ0102030% CD4+ * TNFα IFNγ0.00.51.01.52.0% CD8+ * CD4 CD802468% TNFα+ *** CD4 CD80.00.51.01.5% IFNγ+ **Spike NSP7NSP12 NSP1302468% TNFα+ CD4+ Spike NSP7NSP12 NSP130.00.51.01.5% IFNγ+ CD4+Spike NSP7NSP12 NSP130.00.20.40.60.81.0% TNFα+ CD8+ Spike NSP7NSP12 NSP130.00.20.40.60.81.0% IFNγ+ CD8+" 852 1401 W4223515558.pdf 4 0 paratext 0.7719099 Frank Leonardo Apituley (1) , Amin Setyo Leksono (2) , Bagyo Yanuwiadi (3 0 73 W2119098980.pdf 7 1 separator 0.54469997 ¶ 74 76 W2119098980.pdf 7 2 paratext 0.84002924 ¶ 92 78 83 W2119098980.pdf 7 3 separator 0.98772204 ¶ 84 86 W2119098980.pdf 7 4 text 0.9987228 "sedangkan Vespidae mengalami kenaikan pada tempo pertama sampai kedua dan mengalami penurunan pada tempo ketiga sampai keempat (Gambar 5). Hal ini dikarenakan serangga mempunyai mekanisme secara fisiologis untuk mengukur waktu aktifitasnya, yang dikenal sebagai jam biologi. Secara umum jam biologi harian adalah kemampuan serangga untuk menentukan waktu bagi serangga, kapan untuk melakukan aktivitas dan kapan waktu untuk serangga beristirahat. Jam biologi juga dikaitkan dengan periodisitas yang berhubungan dengan bulan dan daur musim." 87 665 W2119098980.pdf 7 5 separator 0.9908433 ¶ 667 669 W2119098980.pdf 7 6 text 0.9989069 "Pada tempo ketiga (12.00-13.15) terlihat kelimpahan serangga polinator mengalami penurunan, hal ini disebabkan karena adanya ketidaksesuaian iklim mikro atau suhu pada lingkungan tersebut. Serangga memiliki kisaran suhu tertentu dimana dia dapat bertahan hidup. Di luar kisaran suhu tersebut serangga akan mati kedinginan atau kepanasan. Pengaruh suhu ini jelas terlihat pada proses fisiologi serangga. Pada suhu tertentu aktifitas serangga tinggi, akan tetapi pada suhu lain akan berkurang atau menurun." 669 1208 W2119098980.pdf 7 7 separator 0.89790934 ¶ 1209 1211 W2119098980.pdf 7 8 text 0.9990706 "Pada umumnya kisaran suhu efektif adalah : suhu minimum 15 0C, suhu optimum 25 0C, dan suhu maksimum 45 0C (Jumar, 2000)." 1211 1340 W2119098980.pdf 7 9 separator 0.65478384 ¶ 1342 1344 W2119098980.pdf 7 10 text 0.9991309 "Serangga merupakan organisme yang bersifat poikiloterm, sehingga suhu badan serangga banyak dipengaruhi oleh suhu lingkungan." 1344 1476 W2119098980.pdf 7 11 separator 0.97020555 ¶ 1477 1479 W2119098980.pdf 7 12 text 0.9991824 "Pada tempo keempat (15.00-16.15) menunjukan bertambahnya kelimpahan dari serangga polinator tertentu meskipun jumlah penambahannya tidak sebanyak tempo sebelumnya, hal ini dikarenakan beberapa aktivitas dari serangga di pengaruhi oleh respon terhadap cahaya yang berperan dalam proses pertumbuhan, perkembangan dan kelangsungan hidup dari serangga tersebut." 1479 1861 W2119098980.pdf 7 13 separator 0.9849138 ¶ 1863 1865 W2119098980.pdf 7 14 text 0.9993071 "Hasil perhitungan nilai indeks diversitas komunitas serangga polinator saat musim berbunga sebesar 2,08 sedangkan nilai indeks diversitas pada saat musim berbuah sebesar 1,27. Hal ini menunjukan bahwa diversitas serangga pada saat musim berbunga dan berbuah di perkebunan apel termasuk kategori rendah (H’>1-2). Kategori rendah pada kedua musim di perkebunan apel ini disebabkan karena aktivitas masyarakat dalam pengelolaan lahan pertanian yang kurang memperhatikan aspek lingkungan serta dipengaruhi oleh faktor lingkungan yang ada dan juga keragaman komponen yang menyusun ekosistem. Menurut Krebs (2001) keanekaragaman jenis untuk mengukur tingkat keteraturan dan kestabilan suatu ekosistem hal ini diartikan bahwa semakin rendah nilai indeks keanekaragaman maka semakin menurun tingkat keteraturan dan kestabilan ekosistem." 1865 2761 W2119098980.pdf 7 15 separator 0.9962275 ¶ 2771 2773 W2119098980.pdf 7 16 title 0.612033 Analisis statistik keanekaragam 2773 2805 W2119098980.pdf 7 17 text 0.9939831 "an serangga polinator saat musim berbunga dan berbuah memiliki hasil yang signifikan dimana nilainya P < 0,001, waktu pengambilan sampel antara musim berbunga dan berbuah juga memiliki hasil yang signifikan dengan nilai P < 0,001. Hal ini menunjukan bahwa antara musim berbunga dan berbuah dan waktu berpengaruh dalam keanekaragaman serangga polinator. Keanekaragaman serangga polinator di suatu habitat dipengaruhi oleh ketersediaan sumber pakan dan faktor lingkungan. Beberapa serangga pengunjung dapat dikategorikan sebagai serangga penyerbuk, yaitu dari ordo Hymenoptera, Diptera dan Lepidoptera (Banjo et all , 2006)." 2805 3478 W2119098980.pdf 7 18 separator 0.991391 ¶ 3479 3481 W2119098980.pdf 7 19 text 0.9994775 "Individu tertinggi dan dominan pada perkebunan apel pada saat musim berbunga adalah famili Syrpidae dari ordo Diptera dengan nilai INP sebesar 39,21 dengan kelimpahan relatif 28,09%, sedangkan pada musim berbuah didominasi oleh famili Vespidae dengan nilai INP sebesar 65,11 dengan kelimpahan relatif 42,38%. Syrpidae disamping bersifat sebagai polinator juga sebagai predator dan dapat bergerak aktif sehingga mampu bertahan hidup dan berkembangbiak sehingga keberadaannya mampu mendominasi suatu komunitas, selain itu hewan ini mampu menghasilkan telur dalam jumlah banyak." 3481 4099 W2119098980.pdf 7 20 separator 0.9916034 ¶ 4101 4103 W2119098980.pdf 7 21 text 0.9906138 "Tingkat kesamaan antar komunitas tiap periode waktu dapat dianalisis dengan menggunakan indeks Bray Curtis . Hasil perhitungan indeks kesamaan Bray Curtis berdasarkan kelompok musim berbunga dan berbuah disajikan pada (Tabel 2)." 4103 4348 W2119098980.pdf 7 0 paratext 0.9747315 "http://www.hts.org.za Open Access HTS Teologiese Studies/Theological Studies ISSN: (Online) 2072-8050, (Print) 0259-9422 Page 1 of 8 Original Research" 0 158 W2888365170.pdf 0 1 separator 0.57517433 ¶ 158 160 W2888365170.pdf 0 2 paratext 0.88687974 "Read online: Scan this QR code with your smart phone or mobile device to read online." 160 260 W2888365170.pdf 0 3 contact 0.97618616 "Author: Diana L. Villegas1 Affiliation: 1Faculty of Theology and Religion, University of the Free State, South Africa Corresponding author: Diana Villegas, dianavilsa@gmail.com" 260 457 W2888365170.pdf 0 4 separator 0.9665562 ¶ 457 459 W2888365170.pdf 0 5 paratext 0.9295631 "Dates: Received: 17 Apr. 2018 Accepted: 23 July 2018 Published: 27 Aug. 2018" 459 542 W2888365170.pdf 0 6 separator 0.9710169 ¶ 542 544 W2888365170.pdf 0 7 paratext 0.92934746 "How to cite this article: Villegas, D.L., 2018, ‘Spirituality and belief: Implications for study and practice of Christian spirituality’, HTS Teologiese Studies/Theological Studies 74(3), 5037. https://doi.org/ 10.4102/hts.v74i3.5037 Copyright: © 2018. The Authors. Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License." 544 937 W2888365170.pdf 0 8 title 0.9637443 Introduction 937 949 W2888365170.pdf 0 9 separator 0.992771 ¶ 949 951 W2888365170.pdf 0 10 text 0.99954224 "In this study, I emphasise that beliefs are always inherent in lived spirituality. According to John Hick (1989), a scholar of religion, offering beliefs that address human questions about dealing with the limitations and sufferings of life as well as the human quest for meaning is a central function of religion in human culture. Based on this theory, I explore the importance of studying how religious beliefs are received and appropriated, particularly in our globalised, pluralistic culture where there is a smorgasbord of beliefs." 951 1503 W2888365170.pdf 0 11 separator 0.92001843 ¶ 1503 1505 W2888365170.pdf 0 12 text 0.99894315 "This article is written from the perspective of the contemporary discipline of Christian spirituality1 which is considered an interdisciplinary endeavour. While adhering to this point of view (this study is itself interdisciplinary), I argue here for the importance of theological reflection regarding beliefs undergirding the spiritual journeys of Christians. Theology studies beliefs from the perspective of a religious denomination’s self-understanding, that is, a confessional standpoint.2 Precisely in our globalised culture, exploring, understanding and developing that self-understanding in terms of living the beliefs of a particular denomination is an important theoretical and practical task." 1505 2226 W2888365170.pdf 0 13 separator 0.92031825 ¶ 2227 2229 W2888365170.pdf 0 14 text 0.9989131 "Theology that helps interpret and understand lived spirituality must take into account contemporary cultural and historical contexts as enculturated theological reflection has a significant interpretive function in the study of Christian spirituality." 2229 2487 W2888365170.pdf 0 15 separator 0.92169774 ¶ 2487 2489 W2888365170.pdf 0 16 text 0.9994017 "This study makes a contribution by exploring the significance of religious belief for contemporary spirituality even as there is a cultural movement towards separating spirituality and religion. The methodology is innovative in that, rather than philosophical or historical arguments, I use theories from the study of religion, sociological studies including one by a theologian, biography and theology to make an argument regarding theological reflection on belief in the field of Christian spirituality." 2489 3007 W2888365170.pdf 0 17 separator 0.99648106 ¶ 3007 3009 W2888365170.pdf 0 18 title 0.98124385 Religion and belief: The case from the study of religion3 3009 3067 W2888365170.pdf 0 19 separator 0.99402916 ¶ 3067 3069 W2888365170.pdf 0 20 text 0.99872243 "John Hick, a major scholar of religion and comparative theology, developed a detailed theory about the emergence of religion in human culture and about a pattern of belief in major world religions." 3069 3270 W2888365170.pdf 0 21 separator 0.74882936 ¶ 3271 3273 W2888365170.pdf 0 22 text 0.9820715 "1.When referencing Christian spirituality, this study presupposes a plurality of interpretations of Christianity ranging from those of different denominations to the many specific forms of Christian spirituality within denominations, such as Orthodox spirituality, Carmelite spirituality or contemplative spirituality. 2.Confession or confessional refers to perspectives from the self-understanding of a religion as opposed to beliefs viewed or studied from a non-religious perspective. 3.Material in this section is based in part on research presented in Villegas (2012:70–73).The aim of this article is to show the inherent connection between spirituality and belief and the significance of this for the study and practice of Christian spirituality. John Hick, a scholar of religion, argues that religions arose in human culture in order to offer beliefs and practices that respond to the human quest for meaning and transcendence. Assuming spirituality refers to consciously living life in terms of such beliefs and rituals, then religion’s function in culture is to provide a spirituality. Based on the latter theory, I argue for the importance of theological or confessional reflection regarding contemporary belief, given that theology reflects on the beliefs of a religion and at its best helps persons understand and integrate their beliefs into the living of life at a particular historical-cultural moment. In our contemporary globalised, pluralistic culture the influence on spiritual practice of multiple sources of wisdom is common, as shown by sociological studies discussed in this study. This cultural context calls for identification, understanding and interpretation of the beliefs of Christians, as well as study regarding how these beliefs fulfil the purpose of religion in human culture, namely offering ways of living with suffering, evil and questions about the meaning of life. I argue such study fulfils both practical and theoretical functions." 3273 5299 W2888365170.pdf 0 23 title 0.8967763 "Spirituality and belief: Implications for study and practice of Christian spirituality" 5299 5388 W2888365170.pdf 0 24 separator 0.97043335 ¶ 5388 5390 W2888365170.pdf 0 25 paratext 0.8705062 "Read online: Scan this QR code with your smart phone or mobile device to read online." 5390 5490 W2888365170.pdf 0 0 paratext 0.95627266 "Materials 2010 , 3 2281" 0 30 W2158508516.pdf 21 1 separator 0.99304354 ¶ 30 32 W2158508516.pdf 21 2 caption 0.9881006 "Figure 9. Experimental values of ionization potential (I p) and electron affinity (E a) of different sized TOPO coated CdSe Qdots (a: 2.3 nm, b: 3.1 nm, c: 3.2 nm, d: 3.5 nm, e: 3.7 nm, f: 3.8 nm, g: 4.0 nm) (Reprinted with permission from [62]. Copyright 2005 " 32 303 W2158508516.pdf 21 3 separator 0.44237614 ¶ 303 304 W2158508516.pdf 21 4 caption 0.95178634 American Chemical Society). 304 332 W2158508516.pdf 21 5 separator 0.98352414 "¶ ¶" 333 343 W2158508516.pdf 21 6 title 0.9937752 3.2.1. Radiative Relaxation 343 371 W2158508516.pdf 21 7 separator 0.9962264 ¶ 372 374 W2158508516.pdf 21 8 text 0.9920516 "Radiative relaxation results in spontaneous luminescence from Q dots. Such luminescence may result from band-edge or near ba nd-edge transitions or from defect and/or activator quantum states. " 374 572 W2158508516.pdf 21 9 separator 0.55761313 ¶ 572 573 W2158508516.pdf 21 10 text 0.99757975 We discuss such emissions in the following sections. 573 626 W2158508516.pdf 21 11 separator 0.99664533 ¶ 627 629 W2158508516.pdf 21 12 title 0.9932909 3.2.1.1. Band-Edge Emission 629 657 W2158508516.pdf 21 13 separator 0.9964587 ¶ 658 660 W2158508516.pdf 21 14 text 0.99972683 "The most common radiative relaxation processes in intrinsic semiconductors and insulators are band-edge and near band-edge (exciton) emission. Th e recombination of an excited electron in the conduction band with a hole in the valence band is called band-edge emission. As noted above, an electron and hole may be bound by a few meV to form an exciton. Therefore, radiative recombination of an exciton leads to near band-edge emission at energies slightly lowe r than the band-gap. The lowest energy states in Qdots are referred as 1se-1sh (also called exciton state) . The full width at half maximum (FWHM) of a room-temperature band-edge emission peak from Qdots varies from 15 to 30 nm depending on the average si ze of particles. For ZnSe Qdots, however, the luminescence can be tuned by size over the spectral range 390 –440 nm with FWHM as narrow as 12.7–16.9 nm [114,115]. The optical absorption spectrum reflects the band structure of th e materials. While PL from bulk semiconductors is fairly simple and well-understood, and can be expl ained by parabolic band theory, the PL from Qdots raises several questions. For example, radiativ e lifetime of 3.2 nm sized CdSe Qdots can be 1 μs at 10K compared to bulk (~1 ns) [116,117]. This was expl ained by the fact that there were surface states that involved in emission [116]. Ba nd structures of semiconductors ar e often determined from either absorption spectra or PLE spectra. The study [116] also showed that these two spectra exhibited different characteristics when th ese spectra were acquired at 15 K. The PLE spectrum was associated" 660 2309 W2158508516.pdf 21 0 paratext 0.9833086 "689 Mem Inst Oswaldo Cruz , Rio de Janeiro, Vol. 112(10), October 2017" 0 72 W2755453995.pdf 8 1 separator 0.9819859 ¶ 72 74 W2755453995.pdf 8 2 text 0.84719086 "IV). In downtown Palmas, L. infantum and L. amazo - nensis DNA was detected in Ny. whitmani pools and Lu. longipalpis pools, respectively (Table IV)." 74 230 W2755453995.pdf 8 3 separator 0.97813904 ¶ 230 232 W2755453995.pdf 8 4 text 0.99768335 "The minimum rates of infection of Ny. whitmani (number of positive pools/number of females analysed) by L. amazonensis and L. infantum in HUs in July (the dry month) were 7%, and 3%, respectively. In November (the rainy month), no Leishmania -infected Ny. whitmani was detected. The minimum rates of infection of Lu. lon - gipalpis by L. amazonensis in HUs were 10% in Novem - ber and 12.5% in July. In November, Leishmania sp. was detected in Bi. flaviscutellata and L. amazonensis was detected in Ev. walkeri and Pi. christenseni (Table IV)." 232 803 W2755453995.pdf 8 5 separator 0.9935599 ¶ 803 805 W2755453995.pdf 8 6 title 0.9883335 DISCUSSION 805 816 W2755453995.pdf 8 7 separator 0.9956317 ¶ 816 818 W2755453995.pdf 8 8 text 0.9993171 "The presence of Leishmania spp. DNA in six Phle - botominae species from HUs and adjacent gallery for - ests in downtown Palmas and the Taquaruçu district suggests that the environments are potentially at risk for the Leishmania transmission. The results also reveal the role of gallery forests in maintaining Leishmania vectors in areas of the Brazilian savanna." 818 1198 W2755453995.pdf 8 9 separator 0.84199977 ¶ 1198 1200 W2755453995.pdf 8 10 text 0.99951214 "The number of species recorded in this study (30) was similar to the number reported by Machado et al. (2012), who registered 32 species. High Phlebotominae diversity has also been reported in studies performed in different cities in this state (Andrade-Filho et al. 2001, Vilela et al. 2011, 2013). Species such as Ny. whitmani , Bi. flaviscutel - lata, and Lu. longipalpis are likely to be involved in the transmission of Leishmania spp. in Palmas." 1200 1671 W2755453995.pdf 8 11 separator 0.97481835 ¶ 1671 1673 W2755453995.pdf 8 12 text 0.99959457 "Species richness and Phlebotominae occurrence were higher in the rural area (Taquaruçu) than in downtown Palmas. Parallel findings were also reported by Cruz et al. (2013) in Bandeirantes, state of Paraná. Meanwhile, Vilela et al. (2011) also observed high species diversity in rural environments, but the abundance of sand flies was higher in urban environments. These results may be due to the presence of forests close to households and animal housing structures, as well as to the presence accumulated organic matter, all of which provides conditions that are conducive to the establishment of a Phlebotomine repro - ductive cycle (Quinnell & Dye 1994, Cruz et al. 2013)." 1673 2381 W2755453995.pdf 8 13 separator 0.9873433 ¶ 2381 2383 W2755453995.pdf 8 14 text 0.9891361 "Species richness was higher in July (the dry month) than in November (the rainy month) in both locations." 2383 2492 W2755453995.pdf 8 15 separator 0.8844184 ¶ 2493 2495 W2755453995.pdf 8 16 text 0.9995707 "Similar findings were reported by Pinheiro et al. (2013) in the state of Rio Grande do Norte and Moraes et al. (2015) in state of Maranhão. In the current study, the soil showed higher amount of organic matter in dry month (see Fig. in Supplementary data). This condition may have con - tributed to the higher population size in this month and, as a result, to the increase in permanent breeding sites. In the dry month, the preferred habitat among the sand fly specimens was the adjacent gallery forests, where higher numbers of females were captured. In November (the rainy month), most of the specimens captured were found in the peridomestic sites, and there were more males than females. The lower number of phlebotomines in gallery forests was observed in the rainy season when the soil was very soaked (see Fig. in Supplementary data). Proba - bly this environmental condition disturbs the species de - velopment in the soil reducing number of breeding sites and consequently population size. The predominance of females over males in this study differed from the find - ings of other authors (Vilela et al. 2011, 2013, Cruz et al. 2013, Pinheiro et al. 2013), and this occurred probably due the food source or climatic changes. However, a de - tailed sex ratio study during a one or two-year period is necessary to test such hypothesis." 2495 3901 W2755453995.pdf 8 17 separator 0.98828673 ¶ 3901 3903 W2755453995.pdf 8 18 text 0.99970907 "PCR has been used in many studies to detect Leish - mania in Phlebotominae species (Quaresma et al. 2012, Vilela et al. 2013). It is more sensitive than dissection fol - lowed by parasitological examination, and it allows for the identification of parasites at the genus, subgenus, and/ or species level (Pita-Pereira et al. 2011). The nested PCR technique using SSU rDNA is more sensitive in the de - tection of trypanosomatids than PCR with ITS1 as a tar - get (El Tai et al. 2000), a factor which would explain the unique positive sample detected using the ITS1 marker." 3903 4498 W2755453995.pdf 8 19 separator 0.98402333 ¶ 4499 4501 W2755453995.pdf 8 20 text 0.9953926 "The rates of infection by Leishmania in vectors are gen - erally low in nature (Paiva et al. 2006). The average rates remained below 3%, and have rarely reached 10% when evaluated by dissection or PCR (Missawa et al. 2010). Based on this, some of our rates were considered high." 4501 4792 W2755453995.pdf 8 21 separator 0.9804398 ¶ 4792 4794 W2755453995.pdf 8 22 text 0.9997326 "In Taquaruçu, Leishmania spp. DNA detected in the Ny. whitmani may be from L. braziliensis , as Ny. whitmani is an important vector of the parasite (Rangel & Lainson 2009). L. amazonensis DNA was detected for the first time in Ny. whitmani , Pa. hermanlenti , and Pi. christenseni from this location. It is known that Ny. whitmani can be infected experimentally with L. amazonensis and may even be a vector of diffuse cutaneous leishmaniasis (Fonteles et al. 2016). Infection by Leishmania sp. detected in Bi. flavis - cutellata from this site may be caused by L. amazonensis , given the known association between these species (Rangel & Lainson 2009). Crithidia fasciculata DNA was detected for the first time in Ny. whitmani from this district, as was DNA of Trypanosoma sp. in Pi. christenseni . In downtown Palmas, DNA of L. infantum was detected in Ny. whitmani , and the presence of L. amazonensis was detected in Ev. walkeri for the first time. Infections of Ny. whitmani by L. infantum were described in state of Minas Gerais, but the biological interactions involved in this infection need to be investigated to determine the role of this vector in parasite transmission (Margonari et al. 2010). The finding of L. in- fantum DNA in Lu. longipalpis at both locations was ex - pected, but L. amazonensis DNA was found in this sand fly species. Experiments have revealed the ability of this vector to transmit L. amazonensis to hamsters (da Silva et al. 1990), and other studies have detected L. amazonensis in Lu. longipalpis (Paiva et al. 2006, Savani et al. 2009)." 4794 6456 W2755453995.pdf 8 23 separator 0.9890544 ¶ 6456 6458 W2755453995.pdf 8 24 text 0.9996267 "The first records of L. amazonensis DNA in Ny. whit- mani , Pi. christenseni , Pa. hermanlenti , and Ev. walkeri in the city of Palmas suggest the possible involvement of these species in the transmission of the diffuse cutaneous form of the disease in this city, where 169 cases of ACL were reported in recent years (data obtained in coopera - tion with the Municipal Secretariat of Health). However, the finding of Leishmania DNA in sand fly species is not the only condition required to declare it a vector. Species distribution must also coincide with that of the disease in humans; the insect must also be found to be infected in peridomestic and domestic environments; it must feed" 6458 7179 W2755453995.pdf 8 0 paratext 0.95290464 Alekseev AV et al.: Outcomes of the “steady-state crisis” experiment212 0 71 W2953948531.pdf 5 1 separator 0.9807544 ¶ 71 73 W2953948531.pdf 5 2 bibliography 0.9971257 "„Alekseev VV (2013) Use of the MUZA program for computational support of experiments in research reactors. Nuclear Reactor Physics 3: 135–140. [in Russian]" 74 236 W2953948531.pdf 5 3 separator 0.94158447 ¶ 236 238 W2953948531.pdf 5 4 bibliography 0.99106216 "„Bobkov VP (1999) Table method to calculate critical heat flux in water-cooled triangular assemblies. Atomic Energy 87(1): 37–43. https://doi.org/10.1007/BF02673204 [in Russian]" 239 424 W2953948531.pdf 5 5 separator 0.9272938 ¶ 424 426 W2953948531.pdf 5 6 bibliography 0.99781173 "„Bobkov VP, Smogalyov IP (2001) On the Accuracy of Describing Different Codes of Critical Heat Flows in Rods Bundles. Heat Power Engineering 3: 21–28. [in Russian]" 427 597 W2953948531.pdf 5 7 separator 0.9176384 ¶ 597 599 W2953948531.pdf 5 8 bibliography 0.9976398 "„Bobkov VP, Yefanov AD, Pometko RS, Smogalyov IP (2011) A modified table for calculating the critical heat fluxes in fuel rod as - semblies in a triangular package. Heat Power Engineering 4: 43–51." 600 803 W2953948531.pdf 5 9 separator 0.5494602 ¶ 804 806 W2953948531.pdf 5 10 bibliography 0.99737585 https://doi.org/10.1134/S0040601511040045 [in Russian] 806 862 W2953948531.pdf 5 11 separator 0.9587605 ¶ 862 864 W2953948531.pdf 5 12 bibliography 0.9974051 "„Bolshakov VV , Ivanov VK, Kobzar LL, Kosourov KB, Oleksyuk DA, Semchenkov YuM (2009) Experimental study of the spacing effect of the spacer grids arrangement on the critical heat fluxes in bundles of rods. Proc. of the 6th International Conference «Safety Assurance of NPPs with VVER», May 26–29. Podolsk. OKB Gidro - press JSC Publ. [CD, track 108]. [in Russian]" 865 1244 W2953948531.pdf 5 13 separator 0.94319874 ¶ 1244 1246 W2953948531.pdf 5 14 bibliography 0.9975004 "„Bolshakov VV , Kobzar LL, Kosourov KB, Oleksyuk DA, Sem - chenkov YuM (2009a) An experimental study of the effect of axial non-uniformity of heat generation on critical heat fluxes in bundles of rods. Proc. of the 6th International Conference “Safety Assurance of NPPs with VVER”, May 26–29. Podolsk. OKB Gidropress JSC Publ. [CD, track 209]. [in Russian]" 1247 1618 W2953948531.pdf 5 15 separator 0.9727645 ¶ 1618 1620 W2953948531.pdf 5 16 bibliography 0.9932375 "„Burukin A V , Ilyenko SA, Izhutov AL (2009) Methodical funda - mentals and results of investigating fission product release from 60 MWd/kgU VVER fuel rods with simulated defects in the MIR reac - tor loop facility. Proc. of the 8th International Conference on VVER " 1621 1896 W2953948531.pdf 5 17 separator 0.553319 ¶ 1896 1897 W2953948531.pdf 5 18 bibliography 0.970908 Fuel Performance, Modeling and Experimental Support, 26 Sep – 04 1897 1962 W2953948531.pdf 5 19 separator 0.8213278 ¶ 1963 1965 W2953948531.pdf 5 20 bibliography 0.8219853 "Oct, Burgas, Bulgaria. Sofia. Institute for Nuclear Research and Nu - clear Energy Bulgarian Academy of Sciences Publ., 250–256." 1965 2096 W2953948531.pdf 5 21 separator 0.9877451 ¶ 2096 2098 W2953948531.pdf 5 22 bibliography 0.9977039 "„Dreganov OI, Shulimov VN, Alekseev A V , Kiseleva IV (2014) Re - sults of the “Steady-State Crisis” Experiment. RIAR Collected Pa - pers 2: 3–9. [in Russian]" 2099 2262 W2953948531.pdf 5 23 separator 0.9353549 ¶ 2262 2264 W2953948531.pdf 5 24 bibliography 0.99522066 "„Dreganov OI, Shulimov VN, Alekseev A V , Kiseleva IV (2015) The “Steady-State Crisis” Experiment and its results. Proc. of the 9th Intern. Sci. Conf. on Safety Assurance of NPPs with VVER. Podolsk. OKB Gidropress JSC Publ., 75. [in Russian] „Goryachev A V , Makhin VM, Kiseleva IV , Shulimov VN (2004) Integral reactor experiments to test multi-component fragments of VVER-440 and VVER-1000 FAs under LOCA conditions. Summa - ry of experimental results. Nuclear Reactor Physics 2: 29–38. [in Russian]" 2265 2787 W2953948531.pdf 5 25 separator 0.97567034 ¶ 2787 2789 W2953948531.pdf 5 26 bibliography 0.9977765 "„Groeneveld DC, Shan JQ, Vasic AZ, Leung LKH, Durmayazd A, Yanga J, Cheng SC, Tanase A (2007) The 2006 CHF look-up ta - ble. Nuclear Engineering and Design 237: 1909–1922. https://doi. org/10.1016/j.nucengdes.2007.02.014" 2790 3018 W2953948531.pdf 5 27 separator 0.9764354 ¶ 3018 3020 W2953948531.pdf 5 28 bibliography 0.98800665 "„Izhutov AL, Burukin A V , Zhemkov IYu, Kalygin VV , Ovchinnikov V A (2015) Capabilities of unique experimental reactor basis of JSC “SSC RIAR” for feasibility of new nuclear fuel. Conference Pro - ceedings Poster «Reactor Fuel Performance Meeting / Top Fuel 2015», 13–17 September, Zurich, Switzerland, ISBN 978-92-95064- 23-2, paper No. TopFuel2015-A0063: 448–457." 3021 3401 W2953948531.pdf 5 29 separator 0.98835516 ¶ 3401 3403 W2953948531.pdf 5 30 bibliography 0.99711597 "„Krylov DA, Lozhkin VV , Smirnov AM (1995) Experimental study of the heat transfer crisis on rod models of VVER fuel assemblies at low pressures and flow rates characteristic of emergency conditions. Proc. of the Conf. Teplofizika-95 1: 174–180. [in Russian]" 3404 3672 W2953948531.pdf 5 31 separator 0.9658539 ¶ 3672 3674 W2953948531.pdf 5 32 bibliography 0.9976727 "„Logvinov SA, Bezrukov YuA, Dragunov YuG (2004) Experimental Substantiation of the Thermohydraulic Reliability of VVER Reac - tors. Moscow. IKTs Akademkniga Publ., 137 pp. [in Russian]" 3675 3865 W2953948531.pdf 5 33 separator 0.96322274 ¶ 3865 3867 W2953948531.pdf 5 34 bibliography 0.9928539 "„Lozhkin VV , Kolmakov AP, Smirnov AM (1998) Computational and experimental study of the crisis of heat transfer and local heating of the coolant on a 19-rod model of VVER fuel assemblies with a cen - tral non-heated rod. Proc. of the Conf. Teplofizika-98 1: 320–329. [in Russian]" 3868 4160 W2953948531.pdf 5 35 separator 0.9812909 ¶ 4160 4162 W2953948531.pdf 5 36 bibliography 0.9970946 "„Nechayeva O, Medvedev A, Novikov V (2003, 2004) Researches оf WWER fuel rods behaviour under RIA accident conditions. Proc. of the 5th Intern. Conf. on VVER Fuel Performance, Modelling and Experimental Support. 29 Sep–3 Oct 2003. Albena, Bulgaria, 2004, 309–318." 4163 4439 W2953948531.pdf 5 37 separator 0.9821837 ¶ 4439 4441 W2953948531.pdf 5 38 bibliography 0.9975924 "„Sergeev VV (1998) Generalization of data on the heat exchange cri - sis during boiling water in pipes and core assemblies. Proc. of the Conf. Teplofizika-98 1: 330–337. [in Russian]" 4442 4630 W2953948531.pdf 5 39 separator 0.9484229 ¶ 4630 4632 W2953948531.pdf 5 40 bibliography 0.9975344 "„Shchekoldin VI, Bykov MA, Zaitsev SI, Bezrukov YuA (1998) Analy - sis of the experimental data on the crisis and the post-crisis heat trans - fer with the help of the calculation codes of the TRAP and RELAP5 / mod 3.2. Proc. of the Conf. Teplofizika-98 1: 295–303. [in Russian]" 4633 4919 W2953948531.pdf 5 0 separator 0.50252426 1 2 W4391418342.pdf 1 1 paratext 0.96987695 "¶ Al-Kufa University Journal f or Biology / VOL.8/ NO.3/ Year: 2016 Print ISSN: 2073 -8854 & Online ISSN: 2311 -6544 54 URL: http://www.uokufa.edu.iq/journals/index.php/ajb/index http://iasj.net/iasj?func=issues&jId=129&uiLanguage=en ¶" 1 305 W4391418342.pdf 1 2 contact 0.8971919 Email: biomgzn.sci@uokufa.edu.iq 315 348 W4391418342.pdf 1 3 separator 0.9932183 ¶ 350 352 W4391418342.pdf 1 4 text 0.9979064 "T which afford the function of calcium binding, inhibition of ATPase action and tropomyosin bonding respectivel y (7). Assessment of blood &/or its constituents were exploited for the estimation of markers, nowadays other samplings for instance spinal or salivary secretions are also used (8, 9)." 353 656 W4391418342.pdf 1 5 separator 0.92047155 ¶ 657 659 W4391418342.pdf 1 6 text 0.99970365 "Saliva has benefits over blood like ease of collection & assessment, hi gh amounts of electrolytes & markers, less invasive and painless in subjects with AMI (pain may magnify necrosis by enhancing catecholamines secretion) (10,11). Furthermore, saliva is easier for resampling if required to confirm diagnosis. However, the nor mal range of salivary TnI in healthy population is not known (12)." 659 1064 W4391418342.pdf 1 7 separator 0.96454906 ¶ 1066 1068 W4391418342.pdf 1 8 text 0.9987 "This study examine the relation between serum (S) & salivary (Sal) TnI & whether saliva could be applied as an alternate practice for diagnosing AMI in case of positive relationship." 1075 1262 W4391418342.pdf 1 9 separator 0.99307305 ¶ ¶ 1264 1270 W4391418342.pdf 1 10 title 0.94052577 Methods: 1270 1279 W4391418342.pdf 1 11 separator 0.991865 ¶ 1281 1283 W4391418342.pdf 1 12 text 0.9996707 "A cross -section study was completed in Merjan Medical city. It comprised of 100 patients in cardiac care unit under a physicia n's management. All diagnosed as AMI for the first time, after physical examination and by ECG & serum enzymes assessment . This study lasted for ten months and throughout this period we had to take history, perform oral examination, interrogate all the patients that had IHD and admitted to the hospital for further management &/or follow up. Meanwhile, we had to review the fin al diagnosis, investigations & echocardiography findings. Exclusion criteria include history of (proven CAD, stable IHD & PCI or CABG), heart failure, non -cardiac causes of elevated Tn levels, cardiac arrhythmias. Plasma & salivary Tn assessment were perf ormed by ELISA® method, according to manufacturing guidelines of Troponin I Ultra (TNIU) assay by VIDAS® technique (25)." 1290 2203 W4391418342.pdf 1 13 separator 0.9682194 ¶ 2204 2206 W4391418342.pdf 1 14 text 0.9996162 "A written consent was obtained for each patient. Subjects were inquired not to eat, drink, smoke, and brush their teeth for one hour be fore saliva collection (12, 24). Subjects asked to wash their mouths with water, and then, swallow entire his mouth content. Unstimulatory – noninvasive 5 ml saliva sampling gained into a sterile tube. Three cc of blood drained after saliva collection. The reafter, both the blood and saliva were centrifuged at 3500 rpm for about 3 -5 minutes, then the samples placed in tubes and kept at -20 °C for further assessment." 2206 2778 W4391418342.pdf 1 15 separator 0.9225296 ¶ 2780 2782 W4391418342.pdf 1 16 text 0.9996233 "T-test was used to match the Tn in blood & saliva and Pearson -correlation used to lin k the linearity. P -value ˂0.05 was regarded significant. The statistical analysis was completed using SBSS - 22 software package. Baseline physical features were assembled for all subjects using a survey formula with fixed questions for their demographic dat a and clinical history. The choice of subjects was completed so that finally no participant had any of the ensuing confounders (may alter Tn measurements per se ): trauma, CHF, kidney failure, hypothyroidism, sepsis, and burns." 2789 3378 W4391418342.pdf 1 17 separator 0.9966298 ¶ 3380 3382 W4391418342.pdf 1 18 title 0.91440976 Results: 3382 3391 W4391418342.pdf 1 19 separator 0.99433315 ¶ 3393 3395 W4391418342.pdf 1 20 text 0.99882054 "Tables (1) shows baseline characteristics of individuals enrolled in the study. Risk factors for all subjects of the study were hypertension (HT), diabetes mellitus (DM) & smoking. The most common was smoking (37%), followed by HT (26%) & then DM (21 %). (79%) were males & (21%) were females, male to female ratio was 3.5 to 1. Mean ages of the patients was 56.5±13.5 years (table -2)." 3401 3797 W4391418342.pdf 1 21 separator 0.8799162 ¶ 3798 3800 W4391418342.pdf 1 22 text 0.999452 "There was week positive significant correlation (r=0.1, P<0.05) between S TnI & Sal TnI concentrations (table 3). There w as no statistical difference noticed in salvia troponin levels between males and females. Also no significant correlation of both serum & salivary TnI with increasing age (table 5)." 3800 4113 W4391418342.pdf 1 23 separator 0.99634993 ¶ 4115 4117 W4391418342.pdf 1 0 separator 0.98705506 ¶ 1 2 W2771527059.pdf 2 1 text 0.9987436 "In the formula, x is a set of fe asible action sets, and ()nox is the action set credibility. According to the multi -objective optimization method, the navigation process of an autonomous mobile robot specifying the starting and ending points can be decomposed into thre e sub actions, namely, obstacle avoidance, keeping the target direction and moving rapidly toward the target. As shown in figure 3." 2 428 W2771527059.pdf 2 2 separator 0.9910703 ¶ 430 432 W2771527059.pdf 2 3 table 0.97099864 "Navigate to the destination point Obstacle avoidanceMoving to the target Keep the Direction of targetMove fast-forwardGyroscope SpeedometerInfrared ranging sensor Camera " 432 626 W2771527059.pdf 2 4 separator 0.918587 ¶ ¶ 626 631 W2771527059.pdf 2 5 caption 0.99241966 "Fig. 3. specifies the navigation process behavior decomposition of the target" 631 712 W2771527059.pdf 2 6 separator 0.97680414 ¶ 714 716 W2771527059.pdf 2 7 text 0.99765426 "According to the decision theory, the weights, priorities and other factors are taken into account . A weighted objective programming method with dynamic interval weight is proposed to obtain the satisfactory solution of the system at present:" 716 972 W2771527059.pdf 2 8 separator 0.9284052 ¶ 974 976 W2771527059.pdf 2 9 math 0.94187397 "(, )( *, *) arg max[ ( , ) ( , ) ( , )] Nmf mf mh mh ao ao vRv wb v wb v wb v     1mf mh aowww , [ , 0.1]mfwo , [ ,0.4]mhwo , [ ,1]aowo ." 976 1139 W2771527059.pdf 2 10 separator 0.9510559 ¶ 1140 1142 W2771527059.pdf 2 11 text 0.9899798 "In the formula, ,mf mh aowww , respectively represent fast forward , keep the target direction and the obstacle avoidance behavior of three su b function weights." 1142 1312 W2771527059.pdf 2 12 separator 0.6561553 ¶ 1314 1316 W2771527059.pdf 2 13 text 0.99723697 "The weighted values of the sub behaviors of the algorithm can be adjusted dynamically within a given interval, so as to ensure that the mobile robot can obtain the most efficient solution in real time." 1316 1524 W2771527059.pdf 2 14 separator 0.9957855 ¶ 1526 1528 W2771527059.pdf 2 15 title 0.989178 "4 Reliability analysis of multi ou tput obstacle avoidance system" 1528 1597 W2771527059.pdf 2 16 separator 0.98796475 ¶ 1599 1601 W2771527059.pdf 2 17 text 0.99857175 "Definition1(multiple behavior output system).If a control system with n behavioral parameters has at least k successful output, and then the system is called k out of n  system [8]. If the outputs of each subsy stem in the system are independent of each other, the reliability function of the system can be expressed as:" 1601 1941 W2771527059.pdf 2 18 separator 0.7870388 ¶ 1943 1945 W2771527059.pdf 2 19 math 0.9614332 "  1 ( ,n) ( ,n) 1( ,,) 1 ,, { ( ) 1 , 2 ,, } { ( ) 1, 2, , }n ni l kx l n n i l kx l iRp p PX i k n x k n xk n             (1)" 1945 2124 W2771527059.pdf 2 20 separator 0.9734685 ¶ 2125 2127 W2771527059.pdf 2 21 text 0.99792904 "In the formula, ()x represents the probability that ( , n)xk is satisfied. ( , n)k represents all subsets of k behaviors that are successfully output in n behavior." 2127 2303 W2771527059.pdf 2 22 separator 0.7682643 ¶ 2304 2306 W2771527059.pdf 2 23 text 0.9811894 "If the system succeeds in output, then the k behavior value is 1, and the n-k behavior value is 0 . For example ,    (2, 3) 1,1, 0 , 1, 0,1 , 0,1,1 , the functio n : 0,1 0,1n is defined as ¶" 2306 2523 W2771527059.pdf 2 24 math 0.9200758 "(()1)1 i i ixi otherwiP sePx " 2533 2582 W2771527059.pdf 2 25 separator 0.97080094 ¶ 2583 2585 W2771527059.pdf 2 26 text 0.9987602 "Aiming at the snake -like rescue robot obstacle avoidance system (2 -out-3) with 3 sub outputs, the independence of obstacle avoidance behavior is analyzed, if the behavior of reliability for123, , PPP , the formula (1) can be used to calculate the system reliability[9-10]." 2585 2872 W2771527059.pdf 2 27 separator 0.9901966 ¶ 2873 2875 W2771527059.pdf 2 28 table 0.8608108 "  1,1,0 , 1,0,1 , 0,1,3 33 3 123 1 1,1,12 ( ,3) (2,3) (3,3) 1 11 33 { } {} 11 3333 1111 12" 2875 2988 W2771527059.pdf 2 29 math 0.8784457 "3( , , ) () () () () () (1,1, 0) (1, 0,1) (0,1,1) (1,1,1) (1i ii lb l b b i ii ii bb ii iiii iiiiRp p p b b b bb pp p                              1 2 3 1 23 123) (1 ) (1 )p p p p pp ppp   " 2988 3272 W2771527059.pdf 2 30 separator 0.9623568 ¶ 3272 3274 W2771527059.pdf 2 31 text 0.99061495 "If X represent s the successful output of child behavior in n behavior, the reliability of the multi output system can be expres sed as" 3275 3417 W2771527059.pdf 2 32 separator 0.7949674 ¶ 3419 3421 W2771527059.pdf 2 33 math 0.96048003 "1(, , ) { }n n lkRp p PX l   (2)" 3421 3484 W2771527059.pdf 2 34 separator 0.81145245 ¶ 3485 3487 W2771527059.pdf 2 35 text 0.95630556 "Which contains the parameter , np binomial random variable function p the probability form can be expressed as(" 3487 3608 W2771527059.pdf 2 36 math 0.75524926 ") { } (1 )i ninpi PX i p pi     , 0,1, ,in ." 3608 3668 W2771527059.pdf 2 37 separator 0.7751311 ¶ 3669 3671 W2771527059.pdf 2 38 text 0.9858402 "When12 n pp p p    , a binomial random variable with parameters , np can describe the reliability of a multi output system." 3671 3810 W2771527059.pdf 2 39 separator 0.9651785 ¶ 3812 3814 W2771527059.pdf 2 40 text 0.9450453 "Theorem 1: for a given behavior set, the reliability ofk out of n  systems has the following propertie s: ¶" 3814 3929 W2771527059.pdf 2 41 math 0.7825261 "( ) ( 1)Rk Rk , 0,1, ,kn ." 3929 3963 W2771527059.pdf 2 42 text 0.43040565 3964 3965 W2771527059.pdf 2 43 separator 0.46136624 ¶ 3965 3966 W2771527059.pdf 2 44 text 0.936288 "Proof: formula (1) can be written in recursive form " 3966 4022 W2771527059.pdf 2 45 separator 0.48616302 ¶ 4022 4023 W2771527059.pdf 2 46 math 0.8451695 "(,)( ) ( 1) ( ) x knRk Rk x  . " 4023 4066 W2771527059.pdf 2 47 text 0.48529458 Since 4066 4071 W2771527059.pdf 2 48 math 0.56448126 ¶ 4071 4073 W2771527059.pdf 2 49 text 0.5527647 (,) 4073 4077 W2771527059.pdf 2 50 math 0.58219534 () 0 ¶ 4077 4083 W2771527059.pdf 2 51 text 0.5318612 4083 4084 W2771527059.pdf 2 52 math 0.5207037 x k 4084 4087 W2771527059.pdf 2 53 text 0.4825757 n 4087 4088 W2771527059.pdf 2 54 math 0.5542595 x 4088 4091 W2771527059.pdf 2 55 text 0.7594596 "¶ , then ( ) ( 1)Rk Rk is proved." 4091 4134 W2771527059.pdf 2 56 separator 0.9714384 ¶ 4136 4138 W2771527059.pdf 2 57 text 0.9988266 "So far, it can be seen that the reliabili ty of the obstacle avoidance system can be expressed as the mean function of the reliability of each sub member. Therefore, the reliability of the whole system can be reflected by changing the reliability of the sub behaviors in the system." 4138 4433 W2771527059.pdf 2 58 separator 0.99644697 ¶ 4435 4437 W2771527059.pdf 2 59 title 0.99114007 5 System debugg ing and analysis 4437 4470 W2771527059.pdf 2 60 separator 0.98595506 ¶ 4473 4475 W2771527059.pdf 2 61 title 0.98325485 5.1 On-board sensor accuracy test 4475 4509 W2771527059.pdf 2 62 separator 0.99082434 ¶ 4511 4513 W2771527059.pdf 2 63 text 0.9913084 "In order to verify the effectiveness and real -time of snake -like rescue robot obstacle avoidance algorithm based on multi -objective optimization. Using the snake - like rescue robot DK -Snake -II developed" 4513 4730 W2771527059.pdf 2 64 paratext 0.948445 "by the MATEC Web of Conferences 139, 00155 (2017) DOI: 10.1051/matecconf/201713900155 ICMITE 2017" 4730 4832 W2771527059.pdf 2 65 separator 0.828312 ¶ 4832 4834 W2771527059.pdf 2 66 paratext 0.983265 3 4834 4836 W2771527059.pdf 2 0 title 0.9895194 PA speci fic psychological and social variables 0 46 W3202654738.pdf 3 1 separator 0.99540365 ¶ 46 48 W3202654738.pdf 3 2 text 0.99940234 "PA efficacy was measured with 5 items using a 4-point Likert scale for responses. Items asked about con fidence overcoming barriers to PA if they had worries, felt depressed, felt tense, felt tired, and were too busy to do PA.33An exploratory factor analysis with varimax rotation offered a 1-factor solution that accounted for 52% variance, with Cronbach's α being 0.85. Scores were summed, and a total PA ef ficacy score (range: 5–20) was generated, with high scores representing high ef ficacy." 48 554 W3202654738.pdf 3 3 separator 0.95535725 ¶ 554 556 W3202654738.pdf 3 4 text 0.9958302 "PA outcome expectations were assessed using 5 items from the Ben- efits of Physical Activity scale34to assess anticipated bene fits of regular PA, including improving physical fitness, appearance, and overall health, helping with weight management, and reducing the risk of poor health." 556 846 W3202654738.pdf 3 5 separator 0.90157634 ¶ 846 848 W3202654738.pdf 3 6 text 0.9994124 "Responses were recorded on a 5-point Likert scale. An exploratory factor analysis with varimax rotation con firmed the unidimensionality of the 5 items with a 1-factor solution that accounted for 56% of the variance, with Cronbach's αbeing 0.79. Scores were summed to generate an outcome expectations score (range: 5 –25), with high scores representing positive outcome expectations." 848 1241 W3202654738.pdf 3 7 separator 0.98079836 ¶ 1241 1243 W3202654738.pdf 3 8 text 0.98139954 The perceived importance of PA was measured with a single item. 1243 1307 W3202654738.pdf 3 9 separator 0.63984275 ¶ 1307 1309 W3202654738.pdf 3 10 text 0.99945086 "Participants were asked to indicate how important they think PA in their life on a 6-point Likert scale, with the responses options of 0 1⁄4 ‘not at all important ’;11⁄4 ‘somewhat unimportant ’;21⁄4 ‘neutral ’;31⁄4 ‘somewhat important ’;41⁄4 ‘important ’; and 5 1⁄4 ‘very important ’. The scale was adapted from W /C19ojcicki et al.,35which originally recorded responses in a 5-point Likert scale ranging from 1 1⁄4 ‘not at all important ’to 51⁄4 ‘very important ’." 1309 1771 W3202654738.pdf 3 11 separator 0.97000116 ¶ 1771 1773 W3202654738.pdf 3 12 text 0.99899936 "Ten items from the Social Support for Exercise Survey Scale36were used to measure social support for PA. Participants used a 5-point Likert scale to indicate how often they received PA support from their fam- ily/friends (e.g., did PA with the participant, encouraged, complained about their PA). An exploratory factor analysis with varimax rotation confirmed the unidimensionality of the 10 items with a 1-factor solution accounting for 91% of the variance with Cronbach's αbeing 0.87. The item scores were summed to generate a total PA social support score (range: 6 –36; one item was reverse-scored), with high scores represent- ing a high level of social support for PA." 1773 2465 W3202654738.pdf 3 13 separator 0.9969268 ¶ 2465 2467 W3202654738.pdf 3 14 title 0.9913356 Statistical analyses 2467 2488 W3202654738.pdf 3 15 separator 0.9960376 ¶ 2488 2490 W3202654738.pdf 3 16 text 0.9996849 "To identify the correlates of changes in PA and SB, 1-year prospective data were used. The outcome variables (changes in PA and SB) had 3 categories (negligible change, decrease and increase). Therefore, multi- nomial logistic regression analysis was used to identify correlates of changes in PA and SB. Explanatory variables which had univariate as- sociations with the outcome variable at /C2020% signi ficance level (as recommended elsewhere37) were identi fied and examined for collin- earity. Outliers and other assumptions of the models were checked, and model fit was assessed before finalising the model. Variables, which did not have signi ficant associations with the outcome variable of interest in the multivariable model at 5% level of signi ficance, were excluded." 2490 3283 W3202654738.pdf 3 17 separator 0.98468804 ¶ 3283 3285 W3202654738.pdf 3 18 text 0.9787076 "The modelling of three categories for PA changes involved estimation of the following 2 equations: i) The likelihood of ‘decrease ’in PA over 1-year vs the likelihood of ‘negligible change ’, and ii) The likelihood of ‘increase ’in PA over 1-year vs the likelihood of ‘negligible change ’." 3285 3585 W3202654738.pdf 3 19 separator 0.63483465 ¶ 3585 3587 W3202654738.pdf 3 20 text 0.9876404 "The modelling of three categories for SB changes involved estimation of the following 2 equations: i) The likelihood of ‘increase ’in SB over 1-year vs the likelihood of ‘negligible change ’, and ii) The likelihood of ‘decrease ’in SB over 1-year vs the likelihood of ‘negligible change ’.All analyses were performed in Stata version 14 (StataCorp LP., Col- lege Station, Texas) with statistical signi ficance set at p<0.05. Only significant factors associated with change are presented as odds ratios (OR) with their 95% con fidence intervals ( CI)." 3587 4151 W3202654738.pdf 3 21 separator 0.99721885 ¶ 4151 4153 W3202654738.pdf 3 22 title 0.9886808 ResultsParticipants 4153 4173 W3202654738.pdf 3 23 separator 0.9952879 ¶ 4173 4175 W3202654738.pdf 3 24 text 0.9986328 "A total of 575 students completed the Wave 1 survey. Two of Wave 1 participants were excluded as they provided incomplete data on PA." 4175 4311 W3202654738.pdf 3 25 separator 0.6066009 ¶ 4311 4313 W3202654738.pdf 3 26 text 0.9991169 "Among 573 students who participated in Wave 1, 397 completed Wave 2 survey. However, 2 participants provided incomplete data at Wave 2 and were excluded. Thus, the analytical sample of this study was 395." 4313 4522 W3202654738.pdf 3 27 separator 0.92190087 ¶ 4522 4524 W3202654738.pdf 3 28 text 0.9912428 "Just over half of the participants (51.9%) who participated in both assessment points were female; the majority were single (92.4%), had healthy BMI (62.8%), and were studying in private universities (58.7%). Seventy-nine percent of the participants ’mothers were stay-at-home, 33.7% had a mother with tertiary education, and 60.2% reported their father had tertiary education. The majority of the students (79.0%) were" 4524 4954 W3202654738.pdf 3 29 separator 0.9884743 ¶ 4954 4956 W3202654738.pdf 3 30 title 0.98162997 Table 1 4956 4964 W3202654738.pdf 3 31 separator 0.9529618 ¶ 4964 4966 W3202654738.pdf 3 32 title 0.6649419 Characteristics of the participating young adults in Dhaka, Bangladesh,2015 – 4966 5044 W3202654738.pdf 3 33 table 0.5524047 2016, ( n1⁄4395) 5044 5058 W3202654738.pdf 3 34 separator 0.7001883 ¶ 5058 5060 W3202654738.pdf 3 35 table 0.99459934 "a. Characteristics n % Age (years) 18-20 184 46.621-24 211 53.4 Gender Male 190 48.1Female 205 51.9 Marital status Single 365 92.4Married or others 30 7.6 BMI Underweight 91 23.0Healthy weight 248 62.8Overweight 56 14.2 University type Public 163 41.3 Private 232 58.7 Mother's educational quali fication Up to secondary (or equivalent) 178 45.1Higher secondary (or equivalent) 84 21.3Tertiary (or equivalent) 133 33.7 Father's educational quali fication Up to secondary (or equivalent) 75 19.0 Higher secondary (or equivalent) 82 20.8Tertiary (or equivalent) 237 60.2 Mother's employment status Working 83 21.1Stay-at-home 310 78.9 Father's occupation Government/public service 103 27.9 Non-government/private service 63 17.1 Professional 31 8.4Self-employed/business 139 37.7Farmer/day labourer 33 8.9 Monthly gross family income (in BDT) * /C2020,000 74 19.0 20,001 –40,000 98 25.1 40,001 –70,000 125 32.1 >70,000 93 23.9 Living arrangement Living alone 15 3.8Living with parents (or other family members) 237 60.2Living with friends 142 36.0 Accommodation type University accommodation (i.e., dormitory) 83 21.0 Outside university 312 79.0 an1⁄4395 includes those who participated in both Waves." 5060 6324 W3202654738.pdf 3 36 separator 0.8541907 ¶ 6324 6326 W3202654738.pdf 3 37 table 0.79667366 "*BDT1⁄4Bangladeshi Taka (local currency); 10,000 BDT 1⁄4120.52 United States dollar (USD) as of" 6326 6420 W3202654738.pdf 3 38 paratext 0.8442833 29 Apr. 2018.R. Uddin et al. Sports Medicine and Health Science 3 (2021) 236 –242 6420 6502 W3202654738.pdf 3 39 separator 0.6922886 ¶ 6502 6504 W3202654738.pdf 3 40 paratext 0.94043374 238 6504 6508 W3202654738.pdf 3 0 separator 0.99635136 ¶ 1 2 W3111174926.pdf 11 1 title 0.98893416 MEETING ROSTER 4 19 W3111174926.pdf 11 2 separator 0.994272 ¶ ¶ 21 28 W3111174926.pdf 11 3 text 0.9513749 "The roster for this review meeting is displayed as an aggregated roster that includes reviewers from multiple Center for Scientific Review Special Emphasis Panels of the AARR IRG for the 2015/01 council round." 28 242 W3111174926.pdf 11 4 separator 0.7569775 ¶ 244 246 W3111174926.pdf 11 5 text 0.80218184 This roster is available at : 246 276 W3111174926.pdf 11 6 separator 0.5563593 ¶ 277 279 W3111174926.pdf 11 7 text 0.45436582 http://www.csr.nih.gov/SummaryStatementRoster/AARR201501.pdf 279 340 W3111174926.pdf 11 8 separator 0.9726903 "¶ ¶" 342 353 W3111174926.pdf 11 0 paratext 0.7802605 1 3four 0 7 W4214862186.pdf 5 1 title 0.8489103 Black/African American individuals lives below pov - 7 60 W4214862186.pdf 5 2 separator 0.9302906 ¶ 60 62 W4214862186.pdf 5 3 text 0.9712553 "erty, compared with one in twelve White American individu- als, and among individuals 125% below poverty line, 67.9% are Black/African American [57]." 62 214 W4214862186.pdf 5 4 separator 0.9827616 ¶ 214 216 W4214862186.pdf 5 5 title 0.72307855 The neighborhood and housing environment 216 257 W4214862186.pdf 5 6 text 0.9936972 "of Black/ African Americans as a population, compared with the White population, reflects persisting patterns of inequity resulting from US policies and practices of residential segregation by race, redlining, and zoning and access restrictions that in turn determine the food environment and exposures to toxicity for Black/African Americans [ 66, 75–77]. Among persons residing in high poverty neighborhoods/census tracts in the USA (Table 4), 1 in 5 is African American, and among those residing in extreme poverty neighborhoods, 1 in 4 is Black/African American [58, 62]. Home ownership remains low among Black/African American adults [59, 60], due to ineq- uities in income, occupation, and wealth; residential segrega-tion practices; and mortgage denial rates. In 2020, although Black/African Americans comprised 12% of the US popu-lation, they comprised 39% of the homeless population, as compared with White Americans, who comprised 74% of the US population and 48% of the homeless population [78]. Inequity in access to food is also reflective of the patterns in income, poverty, and neighborhood environment, with the Black/African American population experiencing food inse-curity at three times the rate of the White population [61]." 257 1514 W4214862186.pdf 5 7 title 0.9849213 Table 4 Ex amples of racial inequities in social determinants of health 1514 1587 W4214862186.pdf 5 8 separator 0.951486 ¶ 1587 1589 W4214862186.pdf 5 9 table 0.49328765 1 1589 1591 W4214862186.pdf 5 10 text 0.49230975 Expansion 1591 1601 W4214862186.pdf 5 11 table 0.4934402 s 1601 1603 W4214862186.pdf 5 12 text 0.5152572 tates are 1603 1613 W4214862186.pdf 5 13 table 0.48202097 1613 1614 W4214862186.pdf 5 14 text 0.57649094 those that expanded Medicaid by January 1, 2019. As of that date, there were 17 states that had not yet expanded 1614 1726 W4214862186.pdf 5 15 table 0.73822963 MedicaidSocial determinant of health Black/African Americans White Americans 1726 1803 W4214862186.pdf 5 16 separator 0.8037313 ¶ 1803 1805 W4214862186.pdf 5 17 table 0.99237806 "Educational attainment (quantity) High school or more [52] 89.4% 91.3% Bachelor’s degree [52] 27.8% 37.5% Advanced degree [65] 9.9% 14.0% Educational achievement (quality) [53] Proficient literacy 23% 58% Basic or below basic literacy 75% 42% Income and wealth Median household income [57] $45,870 $71,231 Population below poverty [57] 19.5% 8.2% Population 125% below the poverty line [57] 25.6% 11.0% Median wealth [56] $24,100 $188,200 Employment and occupation Unemployment rate [54] 11.4% 7.3% Occupation [55] Management, professional, and related occupations 9.7% 78.7% Janitors, building cleaners 17.0% 74.7% Baggage porters, bellhops 24.6% 61.1% Means of transportation to work: Public transportation [63] 11.1% 3.1% Workers without a vehicle at home [63] 9.5% 2.8% " 1805 2660 W4214862186.pdf 5 18 separator 0.67169803 ¶ 2660 2661 W4214862186.pdf 5 19 table 0.9894795 "Neighborhood and housing Among residents in high poverty neighborhoods/census tracts [58] 20% 4% Among residents in extreme poverty neighborhoods/census tracts [62] 25.2% 7.5% Home ownership rate [59] 45.3% 71.3% Mortgage applications denied rate [60] 18.1% 6.9% Among homeless persons [78] 39.4% 48.3% Among homeless families with children [78] 53.1% 35.0% Food environment [61] Food insecurity 21.7% 7.1% Very low food insecurity 8.0% 3.0% Health care [64] Working-age adults without health insurance coverage 14.2% 9.0% Working-age adults without health insurance coverage, expansion s tate110.2% 6.9% Working-age adults without health insurance coverage, non-expansion state 18.9% 13.0%" 2661 3406 W4214862186.pdf 5 20 paratext 0.9865082 122 Current Diabetes Reports (2022) 22:117–128 3406 3452 W4214862186.pdf 5 0 paratext 0.9865384 Высшее образование в России • No 8/9, 2020146 0 44 W3092829855.pdf 4 1 separator 0.99483776 ¶ 44 46 W3092829855.pdf 4 2 text 0.5514569 "тры (показатели) в пределах установленной шкалы, например, от 0 до 5." 46 119 W3092829855.pdf 4 3 caption 0.39166063 На рисунке 119 130 W3092829855.pdf 4 4 separator 0.54268265 ¶ 130 132 W3092829855.pdf 4 5 caption 0.39686596 2 133 135 W3092829855.pdf 4 6 separator 0.98452556 ¶ 135 137 W3092829855.pdf 4 7 text 0.90066993 при- 138 143 W3092829855.pdf 4 8 separator 0.75261575 ¶ 143 145 W3092829855.pdf 4 9 text 0.9994035 ведены примеры таких финальных слайдов презентаций онлайн-опроса, проведённого среди обучающихся инженерных и творче-ских направлений подготовки по заверше-нии обучения по самой сложной, с их точ-ки зрения, дисциплине весеннего семестра («Сопротивление материалов»). Вопрос звучал следующим образом: «Насколько при изучении дисциплины Вам было...». По-добное анонимное голосование с помощью сервиса Мentimeter эффективно применя-лось как инструмент формирующего оцени-вания, когда было нужно определить общий уровень понимания темы, вопроса или сло-жившейся ситуации обучающимися в син-хронном режиме («здесь и сейчас»). Обрат-ная связь от обучающихся к преподавателям представлялась более важной, чем связь об-учающихся между собой. Все проведённые опросы имели ряд положительных свойств, так как позволяли голосующему избежать стереотипного мышления и выразить от-крыто личное мнение. Точность результатов возросла за счёт отсутствия давления, кри-тики или отрицательной оценки со стороны окружающих, а респондентам было легче выразить себя. Избегание откровенной об-ратной связи или неумение реализовать в ней критику конструктивно не связаны с чисто дидактическими причинами [5]. Как известно, психологические и социальные стереотипы громоздят социокультурные препятствия, мешающие переходу образова-тельных учреждений к правильному управ-лению учением и интерактивным методам обучения (ни то, ни другое немыслимо без обратной связи). 145 1582 W3092829855.pdf 4 10 separator 0.9867144 ¶ 1582 1584 W3092829855.pdf 4 11 text 0.99654806 "Системный анализ подобных опросов по- зволил не столько дать объективную оцен-ку деятельности НПР, задействованных в преподавании дисциплины, сколько про-анализировать эффективность самого ин-терактивного взаимодействия участников учебного процесса друг с другом и со сре-дой обучения посредством разнообразных мультимедийных технологий [6]. При этом обнажались проблемы дистанционного об-разования в виде востребованности допол-нительной мотивации у студентов дистан-ционного обучения по сравнению с другими формами обучения, высокой зависимости от наличия технической инфраструктуры, трудоёмкости внесения оперативных изме-нений. Вместе с тем многократно подтверж-дено, что дистанционные технологии – это инструмент для реализации основных прин-ципов личностно-ориентированного подхо-да к обучению [7–9]." 1584 2402 W3092829855.pdf 4 12 separator 0.9784416 ¶ 2403 2405 W3092829855.pdf 4 13 text 0.6578252 "Чтобы повысить уровень овладения обу- чающимися универсальными компетенци-а) б)" 2405 2489 W3092829855.pdf 4 14 separator 0.99447405 ¶ 2489 2491 W3092829855.pdf 4 15 caption 0.9901848 "Рис. 2. Экранные формы онлайн-опроса обучающихся инженерных (а) и творческих (б) направлений подготовки в сервисе Мentimeter" 2491 2619 W3092829855.pdf 4 16 separator 0.77897906 ¶ 2619 2621 W3092829855.pdf 4 17 caption 0.9927894 "Fig. 2. Screen forms of an online survey of students majoring in engineering (a) and arts (b) with the use of Mentimeter service" 2621 2754 W3092829855.pdf 4 18 separator 0.9955574 ¶ 2754 2756 W3092829855.pdf 4 0 text 0.9995387 "nanometre scale is unknown for most synapses, primarily owing to technical difficulties to reliably map their precise spatial distribution. However, (M)Unc13 proteins were recently identified as a molecular marker of SV release sites ( Reddy-Alla et al., 2017 ;Sakamoto et al., 2018 ) and super- resolution (STED) microscopy revealed that these sites surround a cluster of voltage gated Ca2+ channels in the center of AZs of the glutamatergic Drosophila melanogaster neuromuscular junction (NMJ) ( Bo ̈hme et al., 2016 ;Bo ̈hme et al., 2019 )." 0 551 W3007037284.pdf 3 1 separator 0.99093205 ¶ 551 553 W3007037284.pdf 3 2 text 0.9997036 "Here, by relying on the unique advantage of being able to precisely map SV release site:Ca2+- channel topology we study its consequence for short-term plasticity at the Drosophila NMJ. Topolo- gies were measured using electron microscopy (EM) following high pressure freeze fixation (HPF) or STED microscopy of Unc13 which both revealed a broad distribution of Ca2+channel coupling dis- tances. Stochastic simulations were key to identify facilitation mechanisms in the light of heteroge- nous SV release site:Ca2+channel distances. Contrasting these simulations to physiological data revealed that models explaining STF through gradual increase in pV r(from now on called ‘pV r-based models’) are inconsistent with the experiment while models of activity-dependent regulation of the RRP account for STP profiles and synaptic variance." 553 1405 W3007037284.pdf 3 3 separator 0.99428725 ¶ 1405 1407 W3007037284.pdf 3 4 title 0.9673085 Results 1407 1415 W3007037284.pdf 3 5 separator 0.9843967 ¶ 1415 1417 W3007037284.pdf 3 6 title 0.9606921 "Distances between docked SVs and Ca2+channels are broadly distributed" 1417 1489 W3007037284.pdf 3 7 separator 0.9882934 ¶ 1489 1491 W3007037284.pdf 3 8 text 0.9992348 "We first set out to quantify the SV release site:Ca2+channel topology. For this we analysed EM micrographs of AZ cross-sections and quantified the distance between docked SVs (i.e. SVs touching the plasma membrane) and the centre of electron dense ‘T-bars’ (where the voltage gated Ca2+ channels are located Fouquet et al. (2009) ;Kawasaki et al. (2004) ;Figure 1A ). In wildtype animals, this leads to a broad distribution of distances (‘EM dataset wildtype’, Figure 1—figure supplement 1A;Bo ̈hme et al., 2016 ;Bruckner et al., 2017 ). At the Drosophila NMJ, the two isoforms Unc13A and –B confer SV docking and priming, but the vast majority ( ~95%) of neurotransmitter release and docking of SVs with short coupling distances is mediated by Unc13A ( Bo ̈hme et al., 2016 ). We therefore investigated the docked SV distribution in flies expressing only the dominant Unc13A iso- form (Unc13A rescue, see Materials and methods for exact genotypes) which showed a very similar, broad distribution of distances as wildtype animals (‘EM-dataset Unc13A rescue’) ( Reddy-Alla et al., 2017 ;Figure 1A,B ). In both cases, distance distributions were well described by a Rayleigh distribu- tion ( Figure 1B ,Figure 1—figure supplement 1A , solid green lines). The EM micrographs studied here are a cut cross-section of a three-dimensional synapse. To derive the relevant coupling distance distribution for all release sites (including the ones outside the cross-section), the Rayleigh distribu- tion was integrated around a circle ( Figure 1C ), resulting in the following probability density function (pdf, see Materials and methods for derivation):" 1491 3165 W3007037284.pdf 3 9 separator 0.9796088 ¶ 3165 3167 W3007037284.pdf 3 10 math 0.9619122 "g xð Þ1⁄4ffiffiffi 2p ffiffiffiffipp/C1s3/C1x2/C1e/C0x2=2s2ð Þ" 3167 3218 W3007037284.pdf 3 11 separator 0.9709231 ¶ 3218 3220 W3007037284.pdf 3 12 text 0.999366 "These pdfs were more symmetrical than the ones from the cross-sections and peaked at larger distances (as expected from the increase in AZ area with increasing radius) ( Figure 1D ). The estima- tion of this pdf was very robust, resulting in near identical curves for the two EM datasets ( Figure 1— figure supplement 1B )." 3220 3550 W3007037284.pdf 3 13 separator 0.836362 ¶ 3550 3552 W3007037284.pdf 3 14 text 0.9976092 "We also used an independent approach to investigate the distribution of docked SV:Ca2+channel coupling distances without relying on the integration of docked SV observations from cross-sections:Figure 1 continued" 3552 3767 W3007037284.pdf 3 15 separator 0.9836103 ¶ 3767 3769 W3007037284.pdf 3 16 paratext 0.701095 The online version of this article includes the following source data and figure supplement(s) for figure 1: 3769 3878 W3007037284.pdf 3 17 separator 0.9803891 ¶ 3878 3880 W3007037284.pdf 3 18 caption 0.97993535 Source data 1. Source data for graphs in Figure 1 andFigure 1—figure supplement 1 . 3880 3964 W3007037284.pdf 3 19 separator 0.9137944 ¶ 3964 3966 W3007037284.pdf 3 20 caption 0.9757098 "Source data 2. Matlab codes used for data analysis, original images, and instructions for analysis depicted in Figure 1 andFigure 1—figure supple- ment 1 ." 3966 4124 W3007037284.pdf 3 21 separator 0.98486066 ¶ 4124 4126 W3007037284.pdf 3 22 caption 0.9961743 Figure supplement 1. EM + STED vesicle positions are consistent between independent datasets and overlapping with each other. 4126 4252 W3007037284.pdf 3 23 separator 0.98861 ¶ 4252 4254 W3007037284.pdf 3 24 paratext 0.98559386 Kobbersmed et al. eLife 2020;9:e51032. DOI: https://doi.org/10.7554/eLife.51032 4 of 48Research article Neuroscience 4254 4371 W3007037284.pdf 3 0 title 0.5621502 Estimasi Biaya Konseptual pada Jembatan Beton 0 45 W2883364421.pdf 5 1 paratext 0.63010085 ¶ 46 48 W2883364421.pdf 5 2 title 0.538057 dengan Metode Indeks 48 69 W2883364421.pdf 5 3 paratext 0.56149197 Biaya – [Bagyo Mulyono] 69 93 W2883364421.pdf 5 4 separator 0.9901626 ¶ ¶ 94 100 W2883364421.pdf 5 5 text 0.99726564 "Dari Tabel- 3, terlihat bahwa IBJ tahun 2013 lebih kecil dibawah 0,94 dari tahun 2012, menunjukkan bahwa harga material, alat maupun tenaga kerja relative tidak terjadi perubahan. Disisi lain bahwa data proyek di tahun 2012 hanya terdapat satu data (Purbalingga) sehin gga akan mempengaruhi representatif populasi yang berpengaruh pada besarnya indeks." 101 476 W2883364421.pdf 5 6 separator 0.9972173 ¶ 478 480 W2883364421.pdf 5 7 title 0.99216175 E. Model Estimasi Biaya Konseptual 480 516 W2883364421.pdf 5 8 separator 0.9941261 ¶ 517 519 W2883364421.pdf 5 9 text 0.9979906 "Angka Indeks biaya ini diplotkan kedalam sebuah grafik yang menghubungkan antara IBJ (sumbu-y) dan tahun (sumbu-x) , selanjutnya dibuat garis trendline. Model estimasi biaya konseptual tersaji dalam grafik hubungan jembatan dengan waktu (tahun anggaran)." 519 789 W2883364421.pdf 5 10 separator 0.99460447 ¶ 790 792 W2883364421.pdf 5 11 caption 0.9937744 "Gambar-3 . grafik hubungan biaya jembatan dengan waktu (tahun anggaran)" 792 867 W2883364421.pdf 5 12 separator 0.9772583 ¶ ¶ 868 874 W2883364421.pdf 5 13 table 0.91639614 "Tabel-4. Perhitungan biaya jembatan dengan model dan nilai ¶ y = 100.540,56x 404.528.635,44x + 406.914.284.945,27 R2 = 0,93 5.200.000,00 5.400.000,00 5.600.000,00 5.800.000,00 6.000.000,00 6.200.000,00 6.400.000,00 6.600.000,00" 874 1122 W2883364421.pdf 5 14 separator 0.7546942 ¶ 1123 1125 W2883364421.pdf 5 15 table 0.97349155 "2012 2013 Biaya Jembatan per m2 (Rp) Tahun Data Awal Jembatan Lokasi Tahun Luas (m 2) BJ (Rp) Widoro Kebumen 2012 16,65 (4,5x3,7) 5.334.010,26 Kali Katal, Brebes- 2016 40,6 (7x5,8) 7,130,121.60 pada Jembatan Beton Bertulang [Bagyo Mulyono]" 1125 1406 W2883364421.pdf 5 16 separator 0.98926675 ¶ 1408 1410 W2883364421.pdf 5 17 text 0.85356337 "3, terlihat bahwa IBJ tahun 2013 lebih dibawah 0,94 dari tahun 2012, menunjukkan bahwa harga material, alat maupun tenaga kerja relative tidak terjadi perubahan. Disisi lain bahwa data proyek di tahun 2012 hanya terdapat satu data gga akan mempengaruhi representatif populasi yang berpengaruh pada" 1410 1727 W2883364421.pdf 5 18 separator 0.9580662 ¶ 1728 1730 W2883364421.pdf 5 19 title 0.9919133 Model Estimasi Biaya Konseptual 1730 1762 W2883364421.pdf 5 20 separator 0.9892246 ¶ 1764 1766 W2883364421.pdf 5 21 text 0.98385775 "Angka Indeks biaya ini diplotkan kedalam sebuah grafik yang menghubungkan antara IBJ , selanjutnya dibuat Model estimasi biaya konseptual tersaji dalam grafik hubungan biaya per m 2 embatan dengan waktu (tahun anggaran)." 1766 2002 W2883364421.pdf 5 22 separator 0.9147767 ¶ 2004 2006 W2883364421.pdf 5 23 text 0.4853551 2008 2009 W2883364421.pdf 5 24 separator 0.5372082 ¶ 2009 2010 W2883364421.pdf 5 25 text 0.9768738 "jembatan dengan waktu (tahun anggaran) . Berdasarkan Gambar-3, model didapat dengan nilai R=0,93 adalah persamaan polynomial , yaitu: y= 100.540,56t + 406.914.286.088,58 dengan t" 2010 2202 W2883364421.pdf 5 26 separator 0.9812168 ¶ 2203 2205 W2883364421.pdf 5 27 title 0.9922003 F. Pengujian Validasi 2205 2228 W2883364421.pdf 5 28 separator 0.994025 ¶ 2229 2231 W2883364421.pdf 5 29 text 0.99693096 "Untuk mengetahui seberapa besar nilai kesalahan dari pemodelan estimasi maka dilakukan uji validitas. Uji dilakukan dengan dengan memasukkan data tahun anggaran pada persamaan, kemudian dari hasil persamaan dikalikan 110% (biaya per m 2 jembatan yang memperhitungkan PPN). Dari harga per m 2 jembatan rencana (pxl ). Seberapa besar akurasi dari model ini dihitung dengan mencari nilai error . Nilai error yang dimaksud adalah perbandingan antara selisih biaya konseptual RAB awal dibagi dengan RAB" 2231 2764 W2883364421.pdf 5 30 separator 0.6951132 ¶ 2765 2767 W2883364421.pdf 5 31 text 0.9956922 "Berdasarkan Tabel-4, Untuk Jembatan Widoro setelah di validasi didapat nilai Nilai error didapat dari selisih dibagi biaya awal (mengacu Tabel-1). Untuk Kali Katal Brebes nilai error sebesar - 20,60%." 2767 2980 W2883364421.pdf 5 32 separator 0.94102824 ¶ 2981 2983 W2883364421.pdf 5 33 text 0.9960482 "jembatan Kali Katal Brebes proyek terletak di luar populas eks Karesidenan Tegal, sehingga harga material, tenaga kerja dan alat juga berbeda yang pada biaya proyek. Dari hasil validasi dari kedua proyek, bahwa model mempunyai akura rentang estimasi -30 s.d. + 50%." 2983 3268 W2883364421.pdf 5 34 separator 0.8704918 ¶ ¶ 3269 3275 W2883364421.pdf 5 35 table 0.712317 . Perhitungan biaya jembatan dengan model dan nilai error. 3275 3335 W2883364421.pdf 5 36 math 0.6261936 "y = 100.540,56x 2- 404.528.635,44x + 406.914.284.945,27 R2 = 0,93" 3336 3410 W2883364421.pdf 5 37 separator 0.95852673 ¶ 3411 3413 W2883364421.pdf 5 38 table 0.9559689 "2014 2015 Tahun Besarnya Biaya dengan Model Selisih (Rp) BJ i (Rp) BJ ix110% (Rp) BJ i. L (Rp) 5.334.010,26 5.867.411,29 97.692.397,91 (2.308.108,85) 7,130,121.60 7,843,133.76 318,431,230.66 (82,592,304.32) 110 model trendline terbaik dengan" 3413 3701 W2883364421.pdf 5 39 text 0.48055637 nilai R=0, 3701 3712 W2883364421.pdf 5 40 table 0.45868996 93 3712 3714 W2883364421.pdf 5 41 text 0.4855508 adalah persamaan 3714 3731 W2883364421.pdf 5 42 table 0.42488456 ¶ 100.540,56t 2- 404.528.636,58t ¶ 3733 3769 W2883364421.pdf 5 43 text 0.38989264 dengan 3769 3777 W2883364421.pdf 5 44 table 0.3623623 t 3777 3778 W2883364421.pdf 5 45 text 0.45520467 = Tahun. 3779 3788 W2883364421.pdf 5 46 separator 0.5465758 ¶ 3790 3792 W2883364421.pdf 5 47 text 0.96379465 "seberapa besar nilai kesalahan dari pemodelan estimasi maka dilakukan Uji dilakukan dengan dengan anggaran pada persamaan, kemudian dari hasil persamaan dikalikan 110% jembatan yang memperhitungkan 2 dikalikan dengan luas ). Seberapa besar tingkat model ini dihitung dengan mencari nilai yang dimaksud adalah biaya konseptual dengan RAB awal." 3792 4169 W2883364421.pdf 5 48 separator 0.81200475 ¶ 4170 4172 W2883364421.pdf 5 49 text 0.9866697 "Untuk Jembatan Widoro nilai error sebesar -2,31%. Nilai error didapat dari selisih dibagi biaya awal Untuk Kali Katal Brebes didapat 20,60%. Nilai error proyek Kali Katal Brebes cukup besar karena terletak di luar populas i kajian yaitu daerah eks Karesidenan Tegal, sehingga harga material, tenaga kerja dan alat juga berbeda yang berpengaruh Dari hasil validasi dari kedua mempunyai akura si dalam 50%." 4172 4613 W2883364421.pdf 5 50 separator 0.91708636 ¶ 4615 4617 W2883364421.pdf 5 51 table 0.9669962 "Selisih (Rp) Error Value (%) (2.308.108,85) -2,31 (82,592,304.32) - 20,60" 4617 4711 W2883364421.pdf 5 0 text 0.8954748 Proof.Letx∈[a, b]. HÇ_hen, for t∈[a, x)andσ≥1, we have 0 55 W3021959445.pdf 2 1 separator 0.57362056 ¶ 55 56 W3021959445.pdf 2 2 text 0.88922805 the following inequality: 56 82 W3021959445.pdf 2 3 separator 0.8259922 ¶ 82 84 W3021959445.pdf 2 4 math 0.88111407 (x−t)σ−1Ec,δ,k,c 84 101 W3021959445.pdf 2 5 separator 0.87489176 ¶ 101 103 W3021959445.pdf 2 6 math 0.90400344 μ,σ,lω(x −t)μ;p 103 119 W3021959445.pdf 2 0 paratext 0.9740956 "Jurnal Sains dan Teknologi Industri Peternakan 2022, 2 ( 2): 30-36 https://jurnal.umsrappang.ac.id/jstip e-ISSN (2775 -7889) 34" 0 139 W4312690179.pdf 4 1 separator 0.8976068 ¶ 140 142 W4312690179.pdf 4 2 text 0.9954661 "tidak menggunakan hashtag seperti pada akun instagramnya. Pada akun TikTok @nfcrappang, memiliki pengikut sebanyak 65 dan tampilan terbanyak yaitu 1.549 tampilan. Kegiatan promosi yang dilakukan oleh Nur Fried Chicken di akun TikToknya yaitu berupa video -video menarik tentang Nur Fried Chicken. Seperti, video produk, video podcast, dan lain -lain." 143 516 W4312690179.pdf 4 3 separator 0.9690816 ¶ 518 520 W4312690179.pdf 4 4 text 0.99634403 "Selain via social media, kegiatan di rect marketing diselipkan dalam akunInstagram yakni mencantumkan nomor whatsaap, dan alamat lokasi Nur Fried Chicken, jadwal atau waktu buka dan tutup Nur Fried Chicken dan juga link tiktok Nur Fried Chicken. Pesan dan informasi yang disampaikan oleh Nur F ried Chicken kepada konsumen pada akun Instagram mengandung unsur informasional dan emosional. Informasional karena dalam terdapat nama brand dan juga harga dari produk yang sedang dipromosikan. Emosional karena di setiap unggahan menggunakan kalimat -kalim at positif dan lucu. Selain itu hashtag disertakan dalam setiap unggahan. Tanda pagar yang dibuat adalah #nfc, #nurfriedchicken, #chicken, #crispy, #crispychicken, dan #geprek yang dicantumkan pada unggahan yang berisi foto - foto produk Nur Fried Chicken. Tujuan dari pemberian hashtag #nfc dan #nurfriedchicken, ini adalah untuk memudahkan konsumen dalam melakukan pencarian terhadap toko ataupun produk dari Nur Fried Chicken." 520 1568 W4312690179.pdf 4 5 separator 0.9901304 ¶ 1570 1572 W4312690179.pdf 4 6 title 0.9837971 Cafe Bonaparte 1572 1587 W4312690179.pdf 4 7 separator 0.9832461 ¶ 1589 1591 W4312690179.pdf 4 8 text 0.9992105 "Instagram selain berfungsi untuk memberikan informasi secara langsung melalui postingan, juga bertanggung jawab untuk memberikan promosi Bonaparte Coffe House melalui akun Instagram @bonaparte_coffe_house yang dilakukan oleh owner yang mengoperasikan akun Instagram @bonaparte_coffe_house. Kegiatan pokok tersebut telah dilakukan oleh pengelolah media akun Instagram @ bonaparte_coffe_house dan dibuktikan dengan beberapa hasil postingan kegiatan, pengunjung dan menu. Kegiatan pokok pengelola akun Instagram @ bonaparte_coffe_house yang kedua adalah mengabadikan setiap Foto custumer yang datang ke Bonaparte Coffe house." 1591 2262 W4312690179.pdf 4 9 separator 0.9878817 ¶ 2264 2266 W4312690179.pdf 4 10 text 0.9992845 "Pesatnya perkembangan Facebook, dengan jumlah penggunanya yang besar, menawarkan peluang yang sangat menarik bagi semua orang, terutama bagi pa ra pebisnis. Pengguna dapat melakukan aktivitas pemasaran yang lebih baik tanpa mengeluarkan uang. Facebook kemudian memberi pengguna ruang iklan untuk memasarkan atau mempromosikan produk seperti pakaian, sepatu, produk kecantikan, dan bahkan jasa. Kerumu nan ada di sana, dan ada banyak pembeli potensial. Kemudian muncul peluang bisnis, yakni dengan menawarkan tawaran pekerjaan kepada calon pelanggan untuk mengumpulkan dan menjalankan aktivitas di Facebook, Facebook juga bisa menjadi media promosi layanan y ang sangat sederhana dan murah karena bisa menjangkau pasar global" 2266 3036 W4312690179.pdf 4 11 separator 0.9821321 ¶ ¶ 3038 3044 W4312690179.pdf 4 12 caption 0.9913429 Gambar 2. Wawancara owner Cafe Bonaparte 3044 3085 W4312690179.pdf 4 13 separator 0.87696004 ¶ 3087 3089 W4312690179.pdf 4 14 title 0.8273012 Warung Kedaita 3089 3104 W4312690179.pdf 4 15 separator 0.9290401 ¶ 3106 3108 W4312690179.pdf 4 16 caption 0.88716 "Promosi yang dilakukan Kedaita Sidrap melalui media social instagram dan facebook." 3109 3195 W4312690179.pdf 4 17 separator 0.9891381 ¶ 3196 3198 W4312690179.pdf 4 18 text 0.9986011 "Menurut Sudrajat (2016) perkembangan teknologi informasi dan komunikasi yang terus meningkat, setiap tahun jumlah pengguna internet di seluruh dunia termasuk Indonesia semakin meningkat. Selain Facebook, Twitter, Youtube, Path, Line dan BBM yang merupakan sosial media favorit masyarakat Indonesia, Instagram merupakan salah satu sosial media yang berkembang pesat. Dengan semakin banyaknya pengguna, Instagram menjadi peluang besar bagi para pebisnis untuk beriklan." 3198 3696 W4312690179.pdf 4 19 separator 0.9532063 ¶ 3697 3699 W4312690179.pdf 4 20 text 0.9901538 "Kedaita Sidrap juga melakukan promosi di Instagram dan Facebook." 3699 3767 W4312690179.pdf 4 21 separator 0.8721483 ¶ 3769 3771 W4312690179.pdf 4 22 text 0.9968132 "Akun Instagram yang dimili ki yaitu @kedaita_sidrap dengan jumlah pengikutnya mencapai 2.032. dengan postingan sebanyak 240 postingan dengan jumalah like yang didapatkan berjumnlah mulai dari 5 samapi 60 jumlah like. Dalam kegiatan promosinya di akun instagram Kedaita Sidrap menggun akan Bahasa Indonesia, tujuan dialakukannya promosi pada akun Instagram @kedaita_sidrap adalah untuk memperkenalkan Minuman Kedaita Sidrap kepada lebih banyak orang dan memberitahukan menu apa saja yang tersedia di Kedaita Sidrap serta jenis harga minuman yang ada." 3771 4362 W4312690179.pdf 4 23 separator 0.97732425 ¶ 4363 4365 W4312690179.pdf 4 24 text 0.99623007 "Kedaita Sidrap mulai beroperasi di instagram pada tanggal 1 Maret 2020. Kegiatan promosi yang dilakukan oleh Kedaita Sidrap di akun Instagramnya yaitu berupa postingan Gambar menu, vidio promosi menu baru, semua jenis foto Minuman,dan Diskon har ga pada hari - hari tertentu. Selain itu hestag digunakan pada beberapa unggahan tanda pagar yang dibuat adalah #rasabaru digunakan pada foto yang ¶" 4365 4784 W4312690179.pdf 4 0 paratext 0.98975897 Molecules 2023 ,28, 7781 16 of 18 0 33 W4389056401.pdf 15 1 separator 0.99405414 ¶ 33 35 W4389056401.pdf 15 2 title 0.99360156 4.2.6. Quantum Yield Measurements 35 69 W4389056401.pdf 15 3 separator 0.9950295 ¶ 69 71 W4389056401.pdf 15 4 text 0.99860334 "Solid-state emission quantum yields were recorded using a Quanta- 'F-3029 integra- tion sphere from Horiba plugged into a Horiba Fluorolog III, sourced from Horiba Ltd., Kyoto, Japan." 71 259 W4389056401.pdf 15 5 separator 0.99728954 ¶ 259 261 W4389056401.pdf 15 6 title 0.99365944 4.2.7. Temperature-Dependent Photoluminescence Measurements 261 321 W4389056401.pdf 15 7 separator 0.99540555 ¶ 321 323 W4389056401.pdf 15 8 text 0.9989346 "Steady-state emission spectra and luminescence quantum yield measurements were recorded on a Horiba Jobin-Yvon (HJY) Fluorolog-3 (FL3-2iHR550) fluorescence spectroflu- orometer equipped with an IR R928P PMT/HJY FL-1073 detector and with an integrating sphere sourced from HORIBA Europe Research Center, Palaiseau 91120, France. Low temperature measurements were allowed by using an OptistatCF (Oxford Inst.) in the range of 77 K to 300 K sourced from Oxford Instruments, Abingdon OX13 5QX, United Kingdom. Excited-state lifetimes in the range of 80 K to 300 K were measured with a delta hub (TCSPC: Time-Correlated Single-Photon Counting) + delta diode system, allowing us to measure excited-state lifetimes between 500 ps and 10 sand, and with a pulsed xenon source (FL-1035), allowing us to measure excited-state lifetimes longer than 10 s. Solid samples were placed in a quartz sample holder inside the cryostat and maintained at the desired temperature until equilibrium was reached before recording the spectrum. The experimental data were then fitted according to equation 1 where obs,S1,T1, kB, T, and DESTrepresent the observed lifetime, singlet state decay lifetime, triplet state decay lifetime, Boltzmann constant, temperature, and singlet-triplet energy difference, respectively [32]." 323 1650 W4389056401.pdf 15 9 separator 0.99671155 ¶ 1650 1652 W4389056401.pdf 15 10 title 0.9892556 5. Conclusions 1652 1667 W4389056401.pdf 15 11 separator 0.9962243 ¶ 1667 1669 W4389056401.pdf 15 12 text 0.9990021 "This systematic investigation has tackled the very challenging topic of anticipating the nature of the coordination products between a soft metal halide, in this case CuI, and a soft ditopic ligand, in this case diphosphine of the type Ph 2P(CH 2)mPPh 2(1m8)." 1669 1935 W4389056401.pdf 15 13 separator 0.6933224 ¶ 1935 1937 W4389056401.pdf 15 14 text 0.9989941 "We have found a strong stoichiometric dependence, where ligand-poor mixtures form globular complexes preferentially, and vice-versa. We have also found that short-bite ligands form globular SBUs preferentially. Moreover, there is a marked preference for all reaction mixtures used towards 0D complexes. Finally, a prediction tool using emission and excited state lifetimes as markers has been developed for the prediction of globular vs. quasi -planar motifs in unidentified CuI-diphosphine complexes." 1937 2448 W4389056401.pdf 15 15 separator 0.99225974 ¶ 2448 2450 W4389056401.pdf 15 16 text 0.66259104 Supplementary Materials 2450 2474 W4389056401.pdf 15 17 bibliography 0.46414185 : 2474 2475 W4389056401.pdf 15 18 text 0.48284853 The 2475 2480 W4389056401.pdf 15 19 bibliography 0.5191737 following 2480 2489 W4389056401.pdf 15 20 text 0.453834 supporting 2489 2500 W4389056401.pdf 15 21 bibliography 0.5594789 information 2500 2512 W4389056401.pdf 15 22 text 0.5848593 can be downloaded at: 2512 2534 W4389056401.pdf 15 23 bibliography 0.57115537 "https: //www.mdpi.com/article/10.3390/molecules28237781/s1, Figures S1–S177: supplement" 2534 2624 W4389056401.pdf 15 24 text 0.5186606 ary data 2624 2632 W4389056401.pdf 15 25 bibliography 0.6151951 ; 2632 2633 W4389056401.pdf 15 26 separator 0.9260496 ¶ 2633 2635 W4389056401.pdf 15 27 bibliography 0.53409904 Table S1: PL decay lifetimes for 2635 2668 W4389056401.pdf 15 28 text 0.45064476 all 2668 2672 W4389056401.pdf 15 29 bibliography 0.45266938 2672 2673 W4389056401.pdf 15 30 text 0.51433283 compounds 2673 2682 W4389056401.pdf 15 31 bibliography 0.5860004 ". Crystal structures can be accessed from the Cambridge crystallographic database: www.c" 2682 2772 W4389056401.pdf 15 32 text 0.48608777 cdc 2772 2775 W4389056401.pdf 15 33 bibliography 0.49627975 .cam.ac.uk/ 2775 2786 W4389056401.pdf 15 34 text 0.45799854 structures 2786 2796 W4389056401.pdf 15 35 bibliography 0.4873527 / 2796 2797 W4389056401.pdf 15 36 text 0.5061193 [accessed on 2797 2810 W4389056401.pdf 15 37 bibliography 0.41344166 24 2810 2813 W4389056401.pdf 15 38 text 0.60834056 "November 2023] under accession codes 2304966; 2304967; 2304968; 2304969." 2813 2888 W4389056401.pdf 15 39 separator 0.9963968 ¶ 2888 2890 W4389056401.pdf 15 40 bibliography 0.7731099 "Author Contributions: Conceptualization, L.B., A.S. and P .D.H.; methodology, L.B., A.S. and P .D.H.; software, L.B. and A.S.; validation, L.B., A.S., D.F. and P .D.H.; formal analysis, L.B., A.S., D.F. and P .D.H.; investigation, L.B., A.S. and D.F.; resources, C.L. and P .D.H.; data curation, L.B., A.S. and D.F.; writing—original draft preparation, L.B. and P .D.H.; writing—review and editing, L.B. and P .D.H.; visualization, L.B., A.S. and P .D.H.; supervision, C.L. and P .D.H.; project administration, L.B. and P .D.H.; funding acquisition, L.B., C.L. and P .D.H. All authors have read and agreed to the " 2890 3514 W4389056401.pdf 15 41 paratext 0.45143825 "published version of the manuscript" 3514 3551 W4389056401.pdf 15 42 text 0.430848 . 3551 3552 W4389056401.pdf 15 43 separator 0.98763895 ¶ 3552 3554 W4389056401.pdf 15 44 text 0.9892654 "Funding: L.B.: D.F., A.S. and P .D.H. acknowledge the financial support given to this research by the Natural Sciences and Engineering Research Council (NSERC—CRSNG) of Canada (RGPIN- 2019-05289). L.B. acknowledges the financial support given to him by the Fonds de Recherche du Québec—Nature et Technologies (FRQNT) (342862) for the completion of this study. A.S. and C.L. acknowledge the support of the CNRS, the ANR (ANR PRCSMAC and ANR PRCI SUPRALUM), the French “Minist ère de l’Enseignement Sup érieur, de la Recherche et de l’Innovation” and the French “Minist ère des Affaires Étrang ères”." 3554 4163 W4389056401.pdf 15 45 separator 0.9897406 ¶ 4163 4165 W4389056401.pdf 15 46 paratext 0.48237738 Institutional Review Board Statement: Not applicable. 4165 4219 W4389056401.pdf 15 0 paratext 0.60767967 45 0 2 W2761802825.pdf 6 1 title 0.8724397 ОРИГИНАЛЬНЫЕ СТАТЬИ 2 21 W2761802825.pdf 6 2 separator 0.8938838 ¶ 21 23 W2761802825.pdf 6 3 text 0.50127995 23 24 W2761802825.pdf 6 4 title 0.6491915 UROVEST.RU 24 34 W2761802825.pdf 6 5 text 0.9971265 "вого синдрома , требующего введения как нарко - тических , так и ненаркотических анальгетиков , а также с активация мочевой инфекции не зависят от размера конкрементов . Макрогематурия , по- чечные гематомы и повышение уровня креати - нина крови в сравнении с исходным чаще встре - чаются у пациентов с камнями размерами > 15 мм (р <0,05) (табл . 7)." 34 424 W2761802825.pdf 6 6 separator 0.96077454 ¶ 424 426 W2761802825.pdf 6 7 text 0.99776566 "В исследовании не отмечена взаимосвязь послеоперационной гипертермии от уровня лейкоцитов как в крови , так и в моче , при этом выявлена прямая зависимость между послеопе - рационным увеличением уровня сывороточного креатинина и количеством лейкоцитов в крови (r=0,48; р<0,01)." 426 741 W2761802825.pdf 6 8 separator 0.99643874 ¶ 742 744 W2761802825.pdf 6 9 title 0.95297736 Заключение 744 755 W2761802825.pdf 6 10 separator 0.9918406 ¶ 755 757 W2761802825.pdf 6 11 text 0.99861354 "Таким образом , основанная на применении электромагнитных волн ДЛТ является эффектив - ным и безопасным методом монотерапии боль - ных с простыми лоханочными конкрементами ." 757 951 W2761802825.pdf 6 12 separator 0.9022605 ¶ 952 954 W2761802825.pdf 6 13 text 0.9992812 "Наши результаты показывают , что применение ДЛТ при такого рода камнях позволяет добиться их дезинтеграции и полного отхождения за одну госпитализацию в 68,2% наблюдений , а клини - ческая эффективность электромагнитной ДЛТ простых лоханочных камней достоверно связана с их размерами : при камнях ≤15мм к 3 месяцу мониторинга она достигает 96,0%, а при камнях >15мм – 82,8 %. Полное разрушение камня при его размерах ≤ 15 мм происходит в 3⁄4 случаев за 1-2 сеанса ДЛТ, а резидуальные фрагменты опре - деляются через 3 месяца только в 4% наблюде - ний. Напротив , эффективность ДЛТ крупных ло- ханочных камней > 15 мм достоверно ниже : всем больным требуется более 1 сеанса дробления ." 954 1724 W2761802825.pdf 6 14 separator 0.98478174 ¶ 1725 1727 W2761802825.pdf 6 15 text 0.9988845 "Освобождение чашечно -лоханочной системы от камней происходит существенно медленнее , а через 3 месяца в 17,2% случаев имеют место ре- зидуальные камни , что требует применения еще сеансов ДЛТ либо перехода на эндоскопическую хирургию . Также доказано , что уровень и тяжесть осложнений ДЛТ выше при камнях лоханки >15 мм в сравнении с камнями , имеющими диаметр < 15 мм." 1727 2153 W2761802825.pdf 6 16 separator 0.9965944 ¶ 2153 2155 W2761802825.pdf 6 17 title 0.9473399 Выводы 2155 2162 W2761802825.pdf 6 18 separator 0.9938009 ¶ 2162 2164 W2761802825.pdf 6 19 text 0.999336 "ДЛТ простых лоханочных камней размером ≤ 15 мм может быть рекомендована как первая ли- ния лечения с высокой клинической эффективно - стью , а ДЛТ простых лоханочных камней разме - ром > 15мм и плотностью до 1000 HU отличается медленной дезинтеграцией камня , длительным периодом освобождения мочевых путей от кам- ней, высокой частотой резидуальных конкре - ментов , в связи с чем может рассматриваться как одна из опций при выборе способа лечения ." 2164 2673 W2761802825.pdf 6 20 separator 0.91459215 ¶ 2673 2675 W2761802825.pdf 6 21 text 0.9963955 "Исследование не имело спонсорской под- держки . Авторы заявляют об отсутствии кон- фликта интересов ." 2675 2788 W2761802825.pdf 6 22 separator 0.9940412 ¶ 2788 2790 W2761802825.pdf 6 23 bibliography 0.99762714 "1. Seitz C, Fajkovic H. Epidemiological gender-speci fi c as- pects in urolithiasis. World J Urol. 2013;31(5):1087-92. doi: 10.1007/s00345-013-1140-1" 2790 2946 W2761802825.pdf 6 24 separator 0.9479091 ¶ 2946 2948 W2761802825.pdf 6 25 bibliography 0.9976461 "2. Константинова О.В., Шадеркина В.А. Эпидемиологи - ческая оценка мочекаменной болезни в амбулатор - ной урологической практике . Экспериментальная и клиническая урология . 2015;1:11-14." 2948 3152 W2761802825.pdf 6 26 separator 0.9552929 ¶ 3152 3154 W2761802825.pdf 6 27 bibliography 0.99740374 "3. Аполихин О.И., Сивков А.В., Москалева Н.Г.., Солнце - ва Т.В., Комарова В.А. Анализ уронефрологической заболеваемости и смертности в Российской Федера - ции за десятилетний период (2002-2012 гг.) по дан- ным официальной статистики . Экспериментальная и клиническая урология . 2014;2:4-13." 3154 3473 W2761802825.pdf 6 28 separator 0.9637884 ¶ 3473 3475 W2761802825.pdf 6 29 bibliography 0.995502 "4. Коган М.И., Хасигов А.В., Белоусов И.И., Боташев М.И. Эффективность эндоскопической хирургии и дистан - ционной литотрипсии коралловидного нефролитиа - за: монотерапия и комбинированная терапия . Совре - менные проблемы науки и образования . 2012;3:11." 3475 3755 W2761802825.pdf 6 30 separator 0.6006414 ¶ 3755 3757 W2761802825.pdf 6 31 bibliography 0.9307918 "5. Доступно по: http://www.science-education.ru/103- 6093 Ссылка активна на 05.06.2017." 3757 3850 W2761802825.pdf 6 32 separator 0.984499 ¶ 3850 3852 W2761802825.pdf 6 33 bibliography 0.9944293 "6. Хасигов А.В., Хажоков М.А., Белоусов И.И., Коган М.И. Дистанционная литотрипсия или перкутанная нефро -ЛИТЕРАТУРА REFERENCES" 3852 3990 W2761802825.pdf 6 34 separator 0.9554236 ¶ 3990 3992 W2761802825.pdf 6 35 bibliography 0.99729645 "1. Seitz C, Fajkovic H. Epidemiological gender-speci fi c as- pects in urolithiasis. World J Urol. 2013;31(5):1087-92. doi: 10.1007/s00345-013-1140-1" 3992 4148 W2761802825.pdf 6 36 separator 0.9468208 ¶ 4148 4150 W2761802825.pdf 6 37 bibliography 0.9970122 "2. Konstan Ɵ nova OV, Shaderkina VA. Epidemiological evaluaƟ on of the urolithiasis in outpa Ɵ ent prac Ɵ cy. Eksperimental’naya i klinicheskaya urologiya. 2015;1:11- 14. (In Russ.)" 4150 4341 W2761802825.pdf 6 38 separator 0.9719019 ¶ 4341 4343 W2761802825.pdf 6 39 bibliography 0.99692833 "3. Apolikhin OI, Sivkov AV, Moskaleva NG, Solntseva TV, Komarova VA. Analysis of the uronephrological morbid-ity and mortality in the Russian Federa Ɵ on during the 10-year period (2002-2012) according to the o ffi cial staƟ sƟ cs. Eksperimental’naya i klinicheskaya urologiya. 2014;2:4-13. (In Russ.)" 4343 4657 W2761802825.pdf 6 40 separator 0.9603224 ¶ 4657 4659 W2761802825.pdf 6 41 bibliography 0.9972887 "4. Kogan MI, Khasigov AV, Belousov II, Botashev MI. The effi cacy of endoscopy and shock-wave lithotripsy in staghorn nephrolithiasis: monotherapy and combined therapy. Sovremennye problemy nauki i obrazovaniya. 2012;3:11. (In Russ.)" 4659 4902 W2761802825.pdf 6 42 separator 0.8710723 ¶ 4902 4904 W2761802825.pdf 6 43 bibliography 0.96293104 "5. Available at: h Ʃ p://www.science-educa Ɵ on.ru/103- 6093 Accessed June 05, 2017." 4904 4992 W2761802825.pdf 6 44 separator 0.9875319 ¶ 4992 4994 W2761802825.pdf 6 45 bibliography 0.9976761 "6. Khasigov AV, Khajokov MA, Belousov II, Kogan MI. Shock- wave lithotripsy or percutaneous nephrolithotomy in А.В. Хасигов, М.А. Ха жоков, А.В. Ильяш, В.П. Глухов, Ю.Л. Набока, И.А. Гудима" 4994 5187 W2761802825.pdf 6 46 separator 0.9841927 ¶ 5187 5189 W2761802825.pdf 6 47 bibliography 0.6588309 Э 5190 5192 W2761802825.pdf 6 48 title 0.72368264 "ФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ДИСТАНЦИОННОЙ УДАРНО-ВОЛНОВОЙ ЛИТОТРИПСИИ ПРОСТЫХ ЛОХАНОЧНЫХ КАМНЕЙ" 5192 5290 W2761802825.pdf 6 49 separator 0.9690683 ¶ 5290 5292 W2761802825.pdf 6 50 paratext 0.51966566 Вестник ур 5292 5304 W2761802825.pdf 6 51 bibliography 0.4347494 ологии 5304 5310 W2761802825.pdf 6 52 separator 0.8005196 ¶ 5310 5312 W2761802825.pdf 6 53 bibliography 0.66759205 Urology Herald2017;5(3):39-48 5312 5342 W2761802825.pdf 6 0 text 0.9531419 "tions with diffusion. Numerous references are provided for readers interested in these topics." 0 96 W4214580018.pdf 2 1 separator 0.98088264 ¶ 96 98 W4214580018.pdf 2 2 text 0.99806124 "To study the book, a basic background in functional analysis is needed, but all further tools that are used are introduced in the twoMathematical Toolbox chapters. The theory presented there is rather detailed and complete in the sense that the assumptions on the initial data and the rate coefficients are very general and the proofs are presented in full detail. These two volumes provide an informative, extensive and inspiring introduction to the subject accessible to all researchers from graduate students to experienced scientists." 98 653 W4214580018.pdf 2 3 separator 0.99275637 ¶ 653 655 W4214580018.pdf 2 4 bibliography 0.9847307 "Jacek Banasiak, Wilson Lamb and Philippe Laurençot, Analytic Methods for Coagulation-Fragmentation Models, Volumes I+II. CRC Press, 2019, 676 pages, Hardback ISBN 978-0-367-23544-4 (set)." 655 847 W4214580018.pdf 2 5 separator 0.993562 ¶ 847 849 W4214580018.pdf 2 6 contact 0.52143383 Barbara 849 857 W4214580018.pdf 2 7 text 0.9559382 "Niethammer is a professor at the Institute for Applied Mathematics at the University of Bonn. Her research focuses on the analysis of problems with multiple scales and high-dimensional dynamical systems as well as the study of long-time behaviour in models of mass aggregation." 857 1143 W4214580018.pdf 2 8 separator 0.7896903 ¶ 1143 1145 W4214580018.pdf 2 9 contact 0.93926924 niethammer@iam.uni-bonn.de 1145 1172 W4214580018.pdf 2 10 separator 0.90443975 ¶ 1172 1174 W4214580018.pdf 2 11 paratext 0.8309934 DOI 10.4171/MAG-77 1174 1193 W4214580018.pdf 2 12 separator 0.9930757 ¶ 1193 1195 W4214580018.pdf 2 13 text 0.9864398 "Interfaces and Free Boundaries is dedicated to the mathematical modelling, analysis and computation of interfaces and free boundary problems in all areas where such phenomena are pertinent. The journal aims to be a forum where mathematical analysis, partial differential equations, modelling, scientifi c computing and the various applications which involve mathematical modelling meet. Submissions should, ideally, emphasize the combination of theory and application." 1195 1688 W4214580018.pdf 2 14 separator 0.99390066 ¶ 1688 1690 W4214580018.pdf 2 15 contact 0.98818487 "Editors Antonin Chambolle (CNRS and Université Paris-Dauphine) Charles M. Elliott (University of Warwick) Harald Garcke (Universität Regensburg) José Francisco Rodrigues (Universidade de Lisboa)" 1690 1893 W4214580018.pdf 2 16 separator 0.6437142 ¶ 1893 1895 W4214580018.pdf 2 17 contact 0.5403368 For more 1895 1904 W4214580018.pdf 2 18 text 0.44700894 details 1904 1912 W4214580018.pdf 2 19 contact 0.62665397 visit ems.press/ifbAll issues of 1912 1945 W4214580018.pdf 2 20 text 0.31380907 1946 1947 W4214580018.pdf 2 21 paratext 0.3386436 ¶ Volume 1947 1956 W4214580018.pdf 2 22 contact 0.3756399 / 1956 1957 W4214580018.pdf 2 23 text 0.3682765 uni00A 1957 1963 W4214580018.pdf 2 24 paratext 0.49203166 024 (2022) 1963 1973 W4214580018.pdf 2 25 text 0.6327174 "¶ are accessible as open access under EMS Press’ Subscribe to Open programme." 1974 2063 W4214580018.pdf 2 26 separator 0.4615907 2063 2064 W4214580018.pdf 2 27 paratext 0.7286351 ¶ ems.press/ifbInterfaces 2064 2089 W4214580018.pdf 2 28 title 0.7619984 and Free Boundaries 2089 2109 W4214580018.pdf 2 29 separator 0.70237875 ¶ 2109 2111 W4214580018.pdf 2 30 title 0.7971644 Mathematical Analysis, Computation and Applications 2111 2163 W4214580018.pdf 2 31 separator 0.857119 ¶ 2163 2165 W4214580018.pdf 2 32 contact 0.60447675 EMS Press is an imprint of the European Mathe- 2165 2212 W4214580018.pdf 2 33 text 0.45302847 ¶ 2212 2214 W4214580018.pdf 2 34 contact 0.86450267 "matical Society – EMS – Publishing House GmbH Straße des 17. Juni 136/uni00A0| 10623 Berlin | Germany https://ems.press/uni00A0| subscriptions@ems.press" 2214 2371 W4214580018.pdf 2 35 separator 0.97949433 ¶ 2371 2373 W4214580018.pdf 2 36 title 0.9443351 "Interfaces and Free Boundaries" 2373 2406 W4214580018.pdf 2 37 separator 0.954494 ¶ 2406 2408 W4214580018.pdf 2 38 paratext 0.6386627 Mathematic 2408 2419 W4214580018.pdf 2 39 title 0.5061367 al Analysis, Computation 2419 2443 W4214580018.pdf 2 40 paratext 0.6354073 ¶ and Applications 2443 2462 W4214580018.pdf 2 41 separator 0.5719094 ¶ 2462 2464 W4214580018.pdf 2 42 paratext 0.9103114 "Interfaces and Free Boundaries IFBVol. / No. / pp.– /IFBVol. / No. / pp.– / Interfaces and Free Boundaries ISSN 1463-9963 https://ems.pressContents 1 1 " 2464 2627 W4214580018.pdf 2 43 table 0.4289312 ¶ 1 ¶ 2627 2632 W4214580018.pdf 2 44 paratext 0.4096485 1 2632 2635 W4214580018.pdf 2 45 table 0.37903762 ¶ 2635 2636 W4214580018.pdf 2 46 paratext 0.5967006 1 2636 2639 W4214580018.pdf 2 47 separator 0.53367317 ¶ 2639 2640 W4214580018.pdf 2 48 paratext 0.87830997 ADVERTISEMENT 2640 2654 W4214580018.pdf 2 49 separator 0.9467337 ¶ 2654 2656 W4214580018.pdf 2 50 paratext 0.97322696 56 EMS MAGAZINE 123 (2022) 2656 2683 W4214580018.pdf 2 0 title 0.93102515 Table 4. Calculated and analyzed nutrient composition of experimental diets (g/kg, as fed basis). 0 97 W3193656686.pdf 3 1 separator 0.9898101 ¶ 97 99 W3193656686.pdf 3 2 table 0.994375 "SID Ca3.3 3.9 4.4 5.0 5.5 SID P 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 SID Ca: SID P 0.84 0.67 0.56 0.97 0.78 0.65 1.11 0.89 0.74 1.25 1.00 0.83 1.39 1.11 0.92 Total Ca 7.0 7.0 7.0 8.0 8.0 8.0 9.0 9.0 9.0 10.0 10.0 10.0 11.0 11.0 11.0Non-phytate P 3.37 4.87 6.38 3.37 4.87 6.39 3.38 4.88 6.39 3.38 4.88 6.40 3.39 4.89 6.40 Total Ca: Non-phytate P 2.08 1.44 1.10 2.37 1.64 1.25 2.66 1.85 1.41 2.96 2.05 1.56 3.25 2.25 1.72 Dry matter 883 882 878 882 881 878 880 879 876 879 878 875 878 877 873AME (kcal/kg) 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000 3,000Crude protein 220 220 220 220 220 220 220 220 220 220 220 220 220 220 220Digestible protein 179 179 179 179 179 179 179 179 179 179 179 179 179 179 179Starch 356 354 347 353 351 344 350 348 340 347 345 337 344 342 334Crude fat 47.9 48.9 52.2 49.3 50.3 53.6 50.7 51.7 55.0 52.1 53.1 56.4 53.5 54.5 57.8 Crude fiber 28.3 28.2 28.1 28.2 28.2 28.0 28.2 28.1 27.9 28.1 28.0 27.9 28.0 28.0 27.8 Total Ca 7.0 7.0 7.0 8.0 8.0 8.0 9.0 9.0 9.0 10.0 10.0 10.0 11.0 11.0 11.0SID Ca 3.33 3.33 3.33 3.88 3.88 3.88 4.43 4.43 4.43 4.98 4.98 4.98 5.53 5.53 5.53Total P 5.30 6.80 8.30 5.30 6.80 8.30 5.30 6.80 8.30 5.30 6.80 8.30 5.30 6.80 8.30Phytate P 1.93 1.93 1.92 1.93 1.93 1.91 1.92 1.92 1.91 1.92 1.92 1.90 1.91 1.91 1.90SID P 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 4.0 5.0 6.0 Chloride 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 1.9 Sodium 2.3 2.3 3.3 2.3 2.3 3.3 2.3 2.3 3.3 2.3 2.3 3.3 2.3 2.3 3.3Potassium 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11Choline (mg/kg) 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700 1,700Dig. threonine 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60 8.60Dig. alanine 8.13 8.12 8.09 8.12 8.11 8.08 8.10 8.10 8.07 8.09 8.08 8.06 8.08 8.07 8.05Dig. valine 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 9.60 Dig. isoleucine 7.29 7.29 7.30 7.30 7.30 7.30 7.30 7.30 7.31 7.30 7.30 7.31 7.30 7.30 7.31 Dig. leucine 15.0 15.0 15.0 15.0 15.0 15.0 15.0 15.0 14.9 15.0 15.0 14.9 15.0 14.9 14.9Dig. lysine 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8 12.8Dig. arginine 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6 12.6Dig. cysteine 2.93 2.93 2.92 2.93 2.93 2.91 2.92 2.92 2.91 2.92 2.92 2.90 2.91 2.91 2.90Dig. methionine 6.57 6.57 6.58 6.57 6.57 6.59 6.58 6.58 6.59 6.58 6.58 6.60 6.59 6.59 6.60 Dig. methionine + cysteine 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50 9.50" 99 2704 W3193656686.pdf 3 3 separator 0.9766363 ¶ 2704 2706 W3193656686.pdf 3 4 title 0.73236954 Analyzed values 2706 2722 W3193656686.pdf 3 5 separator 0.82909524 ¶ 2722 2724 W3193656686.pdf 3 6 table 0.9909986 "1 Dry matter 883 882 878 882 881 878 880 879 876 879 878 875 878 877 873Total Ca 6.9 7.1 7.3 7.9 7.7 7.8 8.2 9.2 9.1 11.2 10.7 10.2 11.4 11.6 11.0Total P 5.5 7.5 8.7 5.6 7.1 8.6 6.9 7.4 9.0 6.8 7.5 8.7 5.9 7.6 8.9" 2724 2940 W3193656686.pdf 3 7 separator 0.848143 ¶ 2940 2942 W3193656686.pdf 3 8 table 0.8983917 Abbreviations: AME, apparent metabolisable energy; Ca, calcium; Dig., digestible; P, phosphorous; SID, standardized ileal digestible. 2942 3076 W3193656686.pdf 3 9 separator 0.9685433 ¶ 3076 3078 W3193656686.pdf 3 10 table 0.33065543 1 3078 3080 W3193656686.pdf 3 11 bibliography 0.355292 Samples were analyzed 3080 3101 W3193656686.pdf 3 12 caption 0.29581353 in 3101 3104 W3193656686.pdf 3 13 text 0.27755728 trip 3104 3109 W3193656686.pdf 3 14 bibliography 0.4979707 licate.4 DAVID ET AL. 3109 3130 W3193656686.pdf 3 0 title 0.92668355 Table 6. Comparison of the LWC 12to the tunnel LWC and LWC 8The 0 63 W4307445435.pdf 18 1 table 0.67219216 values of test points that were measured multiple times were averaged. 63 134 W4307445435.pdf 18 2 separator 0.9888799 ¶ 134 136 W4307445435.pdf 18 3 table 0.9948029 "Test point Tunnel MVD [μ m]LWC 8/Tunnel LWC LWC 12/Tunnel LWC ε12mm 522 BIWT 16 0.94 1.07 0.49 521 BIWT 18 0.93 1.16 0.53 524 BIWT 24 1.02 1.06 0.61 U13 RTA 24 1.10 1.10 0.66 525 BIWT 34 1.06 1.07 0.72 537 BIWT 61 1.25 1.21 0.70 U15 RTA 102 0.91 0.89 0.85 U18 RTA 102 0.98 0.95 0.84 TP7 RTA 534 1.02 0.95 0.90 TP8 RTA 534 1.02 0.91 0.90" 136 493 W4307445435.pdf 18 4 separator 0.9920361 ¶ 493 495 W4307445435.pdf 18 5 title 0.98716635 8 Conclusions 495 509 W4307445435.pdf 18 6 separator 0.99642193 ¶ 509 511 W4307445435.pdf 18 7 text 0.99922824 "This work investigates the performance of a new, 12 mm diameter TWC cone of the Nevzorov probe using data collected in three different IWTs. We compared the LWC measured with the 12 mm cone to the measurements of the Hotwire and the 8 mm cone of the Nevzorov probe as well as to the tunnel LWC. We found that a large correction needs to be applied to 370 compensate for the low droplet collision efficiency of the cone. We experimentally derived this collision efficiency for three different air speeds using test points with MVDs between 12 and 58 μ m. For the shape of the collision efficiency curve we prescribed the functional form suggested in Korolev et al. (1998b). In order to obtain the highest accuracy, we used the droplet size distributions of each individual test point for the derivation. We verified the capability of the 12 mm cone to collect SLD through a comparison with the tunnel reference instrumentation, which included a WCM-2000 and an IKP. The results indicate 375 that the 12 mm cone has better droplet collection properties than the WCM-2000 when the droplet size exceeds 200 μ m. Even in FZRA conditions, the 12 mm cone does not suffer from any significant losses of LWC, instead our comparison showed a good agreement to the values of the IKP. The 12 mm cone also appears to be better suited for the collection of SLD than the 8 mm cone, because it measured slightly but consistently higher LWC values. The difference between the two cones is however still within their mutual uncertainty range. 380" 511 2064 W4307445435.pdf 18 8 separator 0.98166513 ¶ 2064 2066 W4307445435.pdf 18 9 text 0.9988347 "We subsequently applied the new collision efficiency correction to measurements collected with the 12 mm cone in bimodal distributions and compared the resulting LWCs to those of the 8 mm cone and the tunnel LWC. The comparison showed an agreement within ±20% with the tunnel LWC for all but one test point, highlighting the ability of the 12 mm cone to provide accurate measurements across the entire size range of Appendix O conditions. We observed that some inaccuracies remain in the computed curves at small droplet diameters and caution should therefore be exercised when using the 12 mm cone in 385 conditions that contain strong small droplet modes. For such conditions the collision efficiency curve for the 12 mm cone may " 2066 2809 W4307445435.pdf 18 10 separator 0.70925605 ¶ 2809 2810 W4307445435.pdf 18 11 paratext 0.9820553 19https://doi.org/10.5194/egusphere-2022-647 2810 2855 W4307445435.pdf 18 12 separator 0.56075025 ¶ 2855 2857 W4307445435.pdf 18 13 paratext 0.97034734 "Preprint. Discussion started: 24 August 2022 c Author(s) 2022. CC BY 4.0 License." 2857 2941 W4307445435.pdf 18 14 separator 0.99569905 ¶ 2941 2943 W4307445435.pdf 18 0 paratext 0.98314637 "British Journal of Management, Vol. 32, 219–234 (2021) DOI: 10.1111/1467-8551.12385" 0 85 W2781886741.pdf 0 1 separator 0.978967 ¶ 85 87 W2781886741.pdf 0 2 title 0.97182417 "Embracing Indeterminacy: On Being a Liminal Professional" 87 146 W2781886741.pdf 0 3 separator 0.9789418 ¶ 146 148 W2781886741.pdf 0 4 contact 0.9906579 "CaraReed and Robyn Thomas Cardiff University, Cardiff Business School, Aberconway Building, Colum Drive, Cardiff, CF10 3EU, UK Corresponding author email: reedcj1@cardiff.ac.uk" 148 329 W2781886741.pdf 0 5 separator 0.9931387 ¶ 329 331 W2781886741.pdf 0 6 text 0.9995624 "The rise of the corporate profession has contributed to a more varied and ambiguous professional terrain that is increasingly seen to be indeterminate and fluid. This paper advances the current debate around the development of corporate professions, exploring how practitioners respond to this environment. Drawing on research with public relations practitioners, the paper shows how the idea of being a liminar facilitates the formation of a professional identity in conditions of high indeterminacy. In taking an individual level of analysis of professions, the paper suggests that indeterminacy is a more resonant feature for corporate professionals than previously suggested in the research, but that this inde- terminacy is navigated in professional identity construction through ‘being a liminar’, and thus greater nuance may need to be recognized in the conceptualization of both corporate professions and corporate professionalization. It also demonstrates the use of liminal- ity as a discursive resource in identity construction and with it, challenges the common association of liminality with self-doubt and existential anxiety. In turn, the paper con- siders the implications of the liminal professional identity for the future of contemporary professions, and for understanding the liminal experience." 331 1674 W2781886741.pdf 0 7 separator 0.99690056 ¶ 1674 1676 W2781886741.pdf 0 8 title 0.89314145 Introduction 1676 1689 W2781886741.pdf 0 9 separator 0.99578 ¶ 1689 1691 W2781886741.pdf 0 10 text 0.9930239 "Increasingly, the traditional professional model has been challenged (Freidson, 2001; Macdonald, 2006;Reed,2007;SavageandWilliams,2008)and withitamorevariedprofessionalterrainhasdevel- oped,particularlywiththeemergenceofcorporate professions (Ackroyd, 2016; Heusinkveld et al., 2018; Hodgson, Paton and Muzio, 2015; Kipping and Kirkpatrick, 2013; Kipping, Kirkpatrick and Muzio, 2006; Paton and Hodgson, 2016; Paton, Hodgson and Muzio, 2013). Corporate professions pursue professionalization differently to established professions, where the corporation is considered to be a more dominant stake- holder (Kipping, Kirkpatrick and Muzio, 2006; WegratefullyacknowledgethePRpractitionersthatgave theirtimetotalkabouttheirexperiencesasprofessionals. Wewouldalsoliketothankthereviewersfortheirhelpin refiningthepaper." 1691 2537 W2781886741.pdf 0 11 separator 0.9148864 ¶ 2537 2539 W2781886741.pdf 0 12 text 0.99933016 "ThisresearchwasfundedbyanESRCstudentship,refer- ence number ES/G036268/1.Muzioet al., 2011). Reflecting the institutional focus of work in this area so far, the indication from research into corporate professionalization suggeststhatcompeting‘collegial’and‘corporate’ logics (Hodgson, Paton and Muzio, 2015) have to be navigated by expert occupations. There have been calls to explore further corporate professionalism across a greater range of corpo- rate professions (Muzio and Kirkpatrick, 2011; Muzioet al., 2011) and with greater focus on the consequences of this professionalism for the prac- titioner (Hodgson, Paton and Muzio, 2015). This paper adds to this body of knowledge, exploring aspectsofprofessionalpracticebypublicrelations (PR)professionals." 2539 3329 W2781886741.pdf 0 13 separator 0.97499967 ¶ 3329 3331 W2781886741.pdf 0 14 text 0.99937576 "Liminality has become a popular concept in studies on work organizations as it offers a lens through which to analyse indeterminacy, precar- ityandinsecurityacrossdifferentemploymentsec- tors in contemporary workplaces (S ̈oderlund and Borg, 2018), serving as ‘a prism through which to understand transformations in the contemporary" 3331 3676 W2781886741.pdf 0 15 separator 0.8806145 ¶ 3676 3678 W2781886741.pdf 0 16 paratext 0.97445893 "C/circlecopyrt2019TheAuthors.BritishJournalofManagementpublishedbyJohnWiley&SonsLtdonbehalfofBritishAcademy of Management. Published by John Wiley & Sons Ltd, 9600 Garsington Road, Oxford OX4 2DQ, UK and 350 Main Street, Malden, MA, 02148, USA." 3678 3927 W2781886741.pdf 0 17 separator 0.7190438 ¶ 3927 3929 W2781886741.pdf 0 18 paratext 0.9650966 "This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distri- bution and reproductionin any medium,provided theoriginalwork isproperlycited." 3929 4129 W2781886741.pdf 0 19 separator 0.99480927 ¶ 4129 4131 W2781886741.pdf 0 0 paratext 0.98458785 www.nature.com/scientificreports/6 0 34 W2414348384.pdf 5 1 separator 0.6809702 ¶ 34 36 W2414348384.pdf 5 2 paratext 0.9695436 Scientific RepoRts | 6:19935 | DOI: 10.1038/srep19935 36 92 W2414348384.pdf 5 3 bibliography 0.44704032 micro 92 97 W2414348384.pdf 5 4 text 0.94086266 "cantilever is maintained to be 1 mm. The vibration of the microcantilever was monitored by a laser Doppler vibrometer (Model OFV-5000/534, Polytec, Germany), equipped with a lock-in amplifier (Model EG&G 7260, Signal recovery, USA). The experimental data were collected by a data acquisition card (Model PCI- 6111, NI, USA) and processed by a PC." 97 451 W2414348384.pdf 5 5 separator 0.9944025 ¶ 451 453 W2414348384.pdf 5 6 title 0.7856207 References 453 464 W2414348384.pdf 5 7 separator 0.9924654 ¶ 464 466 W2414348384.pdf 5 8 bibliography 0.99799156 "1. Dohn, S., Hansen, O. & Boisen, A. Cantilever based mass sensor with hard contact readout. Appl. Phys. Lett. 88, 264104; doi: 10.1063/1.2217161 (2006)." 466 624 W2414348384.pdf 5 9 separator 0.8803162 ¶ 624 626 W2414348384.pdf 5 10 bibliography 0.99816895 "2. Sahin, O., Magonov, S., Su, C., Quate, C. F. & Solgaard, O. An atomic force microscope tip designed to measure time-varying nanomechanical forces. Nat. Nanotechnol . 2, 507–514 (2007)." 626 817 W2414348384.pdf 5 11 separator 0.941165 ¶ 817 819 W2414348384.pdf 5 12 bibliography 0.99757713 "3. C., Yim. et al. CO2-Selective Nanoporous Metal-Organic Framework Microcantilevers. Sci. Rep . 5, 10674; doi: 10.1038/srep10674 (2015)." 819 961 W2414348384.pdf 5 13 separator 0.9682353 ¶ 961 963 W2414348384.pdf 5 14 bibliography 0.99817634 "4. Shibata, M., Uchihashi, T., Ando, T. & Ryohei, Y . Long-tip high-speed atomic force microscopy for nanometer-scale imaging in live cells. Sci. Rep . 5, 8724; doi: 10.1038/srep08724 (2015)." 963 1158 W2414348384.pdf 5 15 separator 0.94515693 ¶ 1158 1160 W2414348384.pdf 5 16 bibliography 0.99800986 5. Huefner, M. et al. Microcantilever Q control via capacitive coupling. Appl. Phys. Lett. 101, 173110; doi: 10.1063/1.4764025 (2012). 1160 1298 W2414348384.pdf 5 17 separator 0.91804934 ¶ 1298 1300 W2414348384.pdf 5 18 bibliography 0.99811786 "6. Gaillard, J., Skove, M., Ciocan, R. & Rao, A. M. Electrical detection of oscillations in microcantilevers and nanocantilevers. Rev. Sci. Instrum . 77, 073907; doi: 10.1063/1.2219750 (2006)." 1300 1496 W2414348384.pdf 5 19 separator 0.9388025 ¶ 1496 1498 W2414348384.pdf 5 20 bibliography 0.9981639 "7. Vinante, A., Wijts, G., Usenko, O., Schinkelshoek, L. & Osterkamp, T. Magnetic resonance force microscopy of paramagnetic electron spins at millikelvin temperatures. Nat. Commun. 2, 572; doi:10.1038/ncomms1581 (2011)." 1498 1723 W2414348384.pdf 5 21 separator 0.94285846 ¶ 1723 1725 W2414348384.pdf 5 22 bibliography 0.99812114 "8. Hube, T., Abell, B., Mellema, D., Spletzer, M. & Raman, A. Mode-selective noncontact excitation of microcantilevers and microcantilever arrays in air using the ultrasound radiation force. Appl. Phys. Lett. 97, 214101; doi: 10.1063/1.3521256 (2010)." 1725 1981 W2414348384.pdf 5 23 separator 0.934761 ¶ 1981 1983 W2414348384.pdf 5 24 bibliography 0.99794143 "9. Evans, D. R. et al. Laser Actuation of Cantilevers for Picometre Amplitude Dynamic Force Microscopy. Sci. Rep. 4, 5567; doi: 10.1038/srep05567 (2014)." 1983 2143 W2414348384.pdf 5 25 separator 0.9441263 ¶ 2143 2145 W2414348384.pdf 5 26 bibliography 0.9979711 "10. Y amashita, H. et al. Tip-sample distance control using photothermal actuation of a small cantilever for high-speed atomic force microscopy. Rev. Sci. Instrum . 78, 083702; doi: 10.1063/1.2766825 (2007)." 2145 2357 W2414348384.pdf 5 27 separator 0.9436596 ¶ 2357 2359 W2414348384.pdf 5 28 bibliography 0.99799514 "11. Feng., Z., B. et al. Resonant actuation of microcantilever by pulse wave of one-nth the resonant frequency. Appl. Phys. Lett. 101, 061901; doi: 10.1063/1.4742859 (2012)." 2359 2539 W2414348384.pdf 5 29 separator 0.96231115 ¶ 2539 2541 W2414348384.pdf 5 30 bibliography 0.9980519 "12. Masolin, A., Bouchard, P . O., Martini, R. & Bernack, M. Thermo-mechanical and fracture properties in single-crystal Silicon. J. Mater. Sci . 48, 979–988 (2013)." 2541 2711 W2414348384.pdf 5 31 separator 0.9610014 ¶ 2711 2713 W2414348384.pdf 5 32 bibliography 0.99806017 "13. V’azquez, J., Sanz, P . & Rojas, J. L. S. Behaviour of forbidden modes in the impedance characterization and modeling of piezoelectric microcantilevers. Sensor Actuat A-Phys . 136, 417–425(2007)." 2713 2917 W2414348384.pdf 5 33 separator 0.9460297 ¶ 2917 2919 W2414348384.pdf 5 34 bibliography 0.99811506 14. Akhatov, I. et al. In Springer Handbook of Acoustics . (ed. Rossing, T. D.) 940–941 (Springer, 2007) 2919 3025 W2414348384.pdf 5 35 separator 0.9491385 ¶ 3025 3027 W2414348384.pdf 5 36 bibliography 0.99797934 15. Hall, J. F. Problems encountered from the use (or misuse) of Rayleigh damping. EARTHQ ENG STRUCT D . 35, 525–545(2006). 3027 3151 W2414348384.pdf 5 37 separator 0.91856736 ¶ 3151 3153 W2414348384.pdf 5 38 bibliography 0.9980486 16. Kim, B. et al. Temperature Dependence of Quality Factor in MEMS Resonators. J. Microelectromech. Syst . 17, 755–766 (2008). 3153 3282 W2414348384.pdf 5 39 separator 0.9384227 ¶ 3282 3284 W2414348384.pdf 5 40 bibliography 0.9980309 "17. Rousset, G., Charbonnier, F. & Lepoutre, F. Calculation of thermoelastic bendings of thin plates application to thermal diffusivities measurements. J. Phys. Colloques . 44, 39–42 (1983)." 3284 3478 W2414348384.pdf 5 41 separator 0.957605 ¶ 3478 3480 W2414348384.pdf 5 42 bibliography 0.9980064 "18. Yi, J. W ., Shih, W . Y . & Shih, W . H. Effect of length, width, and mode on the mass detection sensitivity of piezoelectric unimorph cantilevers. J. Appl. Phys . 91, 1680–1686 (2002)." 3480 3673 W2414348384.pdf 5 43 separator 0.94187796 ¶ 3673 3675 W2414348384.pdf 5 44 bibliography 0.9981143 19. Hosaka, H., Itao, K. & Kuroda, S. Damping characteristics of beam-shaped micro-oscillators. Sens. Actuators A . 49, 87–95 (1995). 3675 3809 W2414348384.pdf 5 45 separator 0.8827812 ¶ 3809 3811 W2414348384.pdf 5 46 bibliography 0.9979611 20. Ibach, H. Adsorbate - induced surface stress. J. Vac. Sci. Technol. A . 12, 2240–2245 (1994). 3811 3909 W2414348384.pdf 5 47 separator 0.9868691 ¶ 3909 3911 W2414348384.pdf 5 48 caption 0.99636483 "Figure 5. (a) Measured and calculated vibration amplitudes as a function of distance between the microcantilever and the Al foil. The laser power radiated on the Al foil was 200 mW . (b) The horizontal displacement of the air particles under the interaction of the standing wave. The motion of the air particles is in the direction parallel to the direction of energy transportation of the longitude wave." 3911 4328 W2414348384.pdf 5 0 paratext 0.9829987 Jurnal Ilmiah Pendidikan Pancasila dan Kewarganegaraan , V ol. 7, Nomor 1, Maret 2022 0 85 W4286321682.pdf 4 1 separator 0.6932985 ¶ 85 87 W4286321682.pdf 4 2 paratext 0.98326707 Copyright © 2022 Jurnal Ilmiah Pendidikan Pancasila dan Kewarganegaraan260 87 163 W4286321682.pdf 4 3 separator 0.9873991 ¶ 163 165 W4286321682.pdf 4 4 text 0.9988322 "waris termasuk jenis surat di bawah tangan yang memerlukan pejabat khusus untuk membuat dan mengesahkannya agar memiliki kekuatan hukum (Setiawan, 2019). Surat keterangan ahli waris dapat digunakan sebagai alat bukti selama proses pembuatannya sesuai dengan ketentuan yang berlaku." 165 465 W4286321682.pdf 4 5 separator 0.9585309 ¶ 466 468 W4286321682.pdf 4 6 text 0.99739265 "Surat keterangan ahli waris bagi golongan WNI asli belum diatur dalam kebijakan mengenai tata naskah maupun bentuk surat keterangan." 468 607 W4286321682.pdf 4 7 separator 0.8380554 ¶ 608 610 W4286321682.pdf 4 8 text 0.999393 "Surat keterangan ahli waris merupakan sebuah pernyataan yang bersifat deklaratif yaitu pernyataan keputusan para ahli yang memutuskan sebagai ahli waris dari pewaris (Erwinsyahbana & Harmita, 2017). Kewenangan Notaris dalam membuat surat keterangan ahli waris dibatasi hanya untuk WNI keturunan Tionghoa yang berbentuk akta otentik (Yoga, Kusumadara, & Kawuryan, 2018). Pembuatan surat keterangan ahli waris bagi WNI asli didasarkan kepada hukum adat dan hukum agama dari para ahli warisnya (Sudaryanto, 2010). Pembuatan surat keterangan ahli waris untuk WNI asli juga banyak format dan jenisnya karena tidak adanya kesatuan hukum." 610 1284 W4286321682.pdf 4 9 separator 0.9743152 ¶ 1284 1286 W4286321682.pdf 4 10 text 0.9992487 "Surat keterangan ahli waris bagi WNI asli yang dibuat oleh kepala desa/lurah diberi judul dengan kalimat “Surat Keterangan Ahli Waris” dan isinya lebih mengarah kepada surat pernyataan. Judul surat keterangan ahli waris selama ini tidak sesuai dengan isinya sehingga menimbulkan berbagai perbedaan persepsi. Isi surat keterangan ahli waris setidaknya harus benar-benar mewakili para ahli waris. Pembuatan surat dalam teori administrasi harus ada syarat formil dan materiil (Yusuf & Anam, 2021)." 1286 1811 W4286321682.pdf 4 11 separator 0.99127185 ¶ 1812 1814 W4286321682.pdf 4 12 text 0.99594826 "Mekanisme pembuatan surat keterangan ahli waris tentu saja secara formalitas tidak sesuai dengan aturan yang ada. Pembuatan surat keterangan ahli waris seharusnya dari para pihak ahli waris sendiri bukan dari pihak desa. Pembuatan surat keterangan ahli waris yang tidak sesuai dengan peraturan yang berlaku dapat mencederai legalitas serta adanya perbedaan kewenangan." 1814 2204 W4286321682.pdf 4 13 separator 0.96670294 ¶ 2205 2207 W4286321682.pdf 4 14 text 0.99940366 "Ketidaksesuaian pihak yang membuat surat keterangan ahli waris secara tidak langsung dapat mempengaruhi keabsahannya. Pembuatan surat keterangan ahli waris jika melanggar syarat formil maka kedudukan surat tersebut dapat dibatalkan, sedangkan dari sudut materiil dapat diterima mengingat isi surat lebih bersifat pernyataan sesuai keadaan (Yusuf & Anam, 2021). Mekanisme pembuatan surat yang akan dijadikan sebagai alat bukti harus melalui prosedur yang telah ditetapkan. Prosedur administrasi merupakan tahapan kegiatan untuk menyelesaikan suatu aktivitas serta memecahkan suatu masalah (Hadi & Tomy, 2017). Surat keterangan ahli waris yang dibuat oleh Kepala Desa/Lurah secara langsung menyalahi prosedur yang ada." 2207 2966 W4286321682.pdf 4 15 separator 0.99124384 ¶ 2967 2969 W4286321682.pdf 4 16 text 0.99410886 "Pasal 111 Peraturan Menteri Agraria/ Badan Pertanahan Nasional menjelaskan bahwa pembuatan surat keterangan ahli waris harus berasal dari para ahli waris. Mekanisme pembuatan surat keterangan sebaiknya tidak melibatkan pihak perangkat desa secara langsung. Surat keterangan ahli waris yang telah dibubuhi tanda tangan para ahli waris dan mendapat penguatan dari kepala desa/lurah dan camat tidak cukup menjadi alat bukti saja tetapi harus mendapatkan legalitas yang sah (Rafaldini, Afriana, & Faisal, 2020). Pembuatan surat keterangan ahli waris harus sesuai dengan ketentuan yang telah diatur oleh undang-undang." 2969 3621 W4286321682.pdf 4 17 separator 0.9907353 ¶ 3622 3624 W4286321682.pdf 4 18 text 0.9925228 "Pembuatan surat keterangan ahli waris menjadi tumpang tindih antara ahli waris dan perangkat desa terutama terkait keabsahan penutup surat. Merujuk kepada klausul Pasal 111 Peraturan Menteri Agraria Nomor 3 Tahun 1997 seharusnya penutup surat menggunakan frasa “dikuatkan” dari kepala desa/lurah dan camat yang dibubuhkan setelah saksi dan ahli waris menandatangani surat keterangan ahli waris tersebut (Priyanti, 2019). kepala desa/lurah dan camat dalam praktek pembuatannya sering kali menggunakan frasa “mengetahui” pada bagian penutup. Penggunaan frasa “mengetahui” tidak memenuhi prinsip keabsahan surat keterangan ahli waris sebagai alat bukti yang sah." 3624 4326 W4286321682.pdf 4 19 separator 0.9924462 ¶ 4327 4329 W4286321682.pdf 4 20 text 0.9958932 "Prinsip keabsahan dalam hukum administrasi memiliki tiga fungsi yaitu bagi aparat pemerintahan sebagai norma pemerintahan, bagi masyarakat sebagai alasan mengajukan gugatan terhadap tindakan pemerintah, serta bagi hakim sebagai dasar pengujian suatu tindakan pemerintah." 4329 4615 W4286321682.pdf 4 21 separator 0.9660712 ¶ 4616 4618 W4286321682.pdf 4 22 text 0.9989322 "Prinsip legalitas dalam tindakan pemerintah meliputi wewenang, prosedur, dan substansi (Hadi & Tomy, 2017). Wewenang dan prosedur merupakan landasan bagi legalitas formal sedangkan substansi akan melahirkan legalitas materiil. Ketiga prinsip legalitas jika tidak dipenuhi maka tindakan administrasi pemerintahan akan cacat secara yuridis." 4618 4978 W4286321682.pdf 4 0 paratext 0.99030805 J. Imaging 2019 ,5, 40 3 of 16 0 30 W2922513363.pdf 2 1 separator 0.99506855 ¶ 30 32 W2922513363.pdf 2 2 text 0.99937177 "In electropalatographic investigations of speech, a participant’s speech is recorded while wearing the artificial palate. Tongue contact with the palate activates the electrodes in the contact area, since these react electrically to the humidity of the saliva on the surface of the tongue. The speech recordings can consist of free speech, or more likely, a set of pre-selected sentences that are designed to investigate particular combinations of speech sounds. The temporal sequence of tongue–palate contact patterns is recorded in temporal registration with the acoustic signal. In the present study, the synchronised EPG and audio data were obtained from a freely available web database known as MOCHA (MultiCHannel Articulatory database: English) TIMIT [ 8], which consists of 460 English sentences that include the main connected speech processes and are read by female and male speakers." 32 942 W2922513363.pdf 2 3 separator 0.9902718 ¶ 942 944 W2922513363.pdf 2 4 text 0.78165734 Figure 2 illustrates one 944 969 W2922513363.pdf 2 5 caption 0.5483692 969 970 W2922513363.pdf 2 6 text 0.63620675 sentence of the MOCHA TIMIT 970 997 W2922513363.pdf 2 7 caption 0.5897094 database 997 1006 W2922513363.pdf 2 8 text 0.63930255 ; the sound 1006 1017 W2922513363.pdf 2 9 caption 0.5599523 wave 1017 1021 W2922513363.pdf 2 10 text 0.722188 (recorded at a 16 kHz 1021 1043 W2922513363.pdf 2 11 caption 0.57467836 ¶ sampling rate) is displayed with 1043 1078 W2922513363.pdf 2 12 text 0.58286935 the 1078 1082 W2922513363.pdf 2 13 caption 0.772601 corresponding phonemes separated by vertical dashed lines. 1082 1141 W2922513363.pdf 2 14 separator 0.98937297 ¶ 1141 1143 W2922513363.pdf 2 15 caption 0.9958273 Figure 2. Illustration of an annotated sound wave from the MOCHA (MultiCHannel Articulatory) 1143 1236 W2922513363.pdf 2 16 separator 0.9888091 ¶ 1236 1238 W2922513363.pdf 2 17 text 0.9976422 "TIMIT database. The sentence (“This was easy for us”) is displayed as the title of the figure together with the sentence number in the database. The sound wave is displayed as a blue line and the phonemes are separated by dashed vertical lines. For clarity, the positions of the phoneme labels alternate up and down, with breath and silences (sil) shown in different colours." 1238 1619 W2922513363.pdf 2 18 separator 0.9636307 ¶ 1619 1621 W2922513363.pdf 2 19 text 0.9994505 "The synchronised EPG data are recorded in a separate file. Once a contact is registered by an electrode, an electrical signal is sent to an external processing unit [ 9], and a graphical display of the pattern of electrode excitation is shown either printed on paper or on a screen (Figure 3)." 1621 1918 W2922513363.pdf 2 20 separator 0.9492582 ¶ 1918 1920 W2922513363.pdf 2 21 text 0.9995013 "When palatograms are shown on a screen, they can provide dynamic real-time visual feedback on the location and timing of tongue contacts with the hard palate. This direct articulatory information can be used during therapy to monitor and improve articulation patterns, especially in children [ 10–12]." 1920 2226 W2922513363.pdf 2 22 separator 0.9596174 ¶ 2226 2228 W2922513363.pdf 2 23 text 0.99963474 "Visual feedback is particularly important in rehabilitating children with hearing impairment. EPG has the potential to be useful in the assessment and remediation of a variety of speech disorders [ 13], including those due to hearing impairment [ 14], cleft palate [ 15], and Down’s syndrome [ 12]." 2228 2531 W2922513363.pdf 2 24 separator 0.8792989 ¶ 2531 2533 W2922513363.pdf 2 25 text 0.99961585 "The technique has also been used to study tongue–palate contact patterns for different inventories of vowels and consonants [16,17]." 2533 2668 W2922513363.pdf 2 26 separator 0.9521322 ¶ 2668 2670 W2922513363.pdf 2 27 text 0.99971163 "In phonetic studies of speech production, it has been implicitly assumed that the different postures for speech are symmetrical in the left–right plane of the vocal tract, i.e., that the contact between the tongue and the palate on the right-hand side is equally extensive as the contact on the left. Characterisation of articulation asymmetry in native speakers would contribute to a better understanding of the speech production process and its relationship with both neural organisation and the anatomy of speech organs. From a practical viewpoint, it could provide a reference for Speech and Language Therapists when treating speech deficiencies in which asymmetry plays a role (e.g., dysarthria). For example, if normative data show that a particular speech sound is often produced in a highly symmetrical way, then asymmetrical articulation of this speech sound resulting from weakness or paralysis of the muscles on one side of the mouth (which is very common in speech disorders due to stroke) could result in reduced intelligibility for the sound in question." 2670 3758 W2922513363.pdf 2 0 paratext 0.9427348 Correction to: The role of editors (Dec, 10.1007/S12350021-02862-W, 0 67 W4200217631.pdf 0 1 separator 0.60173297 67 68 W4200217631.pdf 0 2 paratext 0.80532503 ¶ 2021) 68 75 W4200217631.pdf 0 3 separator 0.9858583 ¶ 75 77 W4200217631.pdf 0 4 bibliography 0.7922938 Iskandrian, A.E.; Bax, J.J. 77 105 W4200217631.pdf 0 5 separator 0.96666193 ¶ 105 107 W4200217631.pdf 0 6 paratext 0.8661727 Citation 107 116 W4200217631.pdf 0 7 separator 0.98881304 ¶ 116 118 W4200217631.pdf 0 8 bibliography 0.9614869 Iskandrian, A. E., & Bax, J. J. (2021). Correction to: The role of editors (Dec, 118 200 W4200217631.pdf 0 9 separator 0.5729429 ¶ 200 201 W4200217631.pdf 0 10 bibliography 0.8666604 10.1007/S12350021-02862-W, 2021). Journal Of Nuclear Cardiology , 29, 4-4. 201 276 W4200217631.pdf 0 11 separator 0.5158969 ¶ 276 278 W4200217631.pdf 0 12 paratext 0.8556488 doi:10.1007/s12350-021-02895-1 278 309 W4200217631.pdf 0 13 separator 0.80533504 ¶ ¶ 309 315 W4200217631.pdf 0 14 paratext 0.9530596 "Version: Publisher's Version License: Creative Commons CC BY 4.0 license Downloaded from: https://hdl.handle.net/1887/3279737" 315 445 W4200217631.pdf 0 15 separator 0.8930296 ¶ ¶ 445 451 W4200217631.pdf 0 16 paratext 0.73755795 Note: To cite this publication please use the final published version (if applicable). 451 539 W4200217631.pdf 0 0 paratext 0.8996197 21 0 2 W3136247815.pdf 22 1 separator 0.99315137 ¶ 3 5 W3136247815.pdf 22 2 text 0.97525364 to rise in many places and as we wonder how social boundaries between groups will co -evolve 6 102 W3136247815.pdf 22 3 separator 0.5886409 ¶ 102 103 W3136247815.pdf 22 4 text 0.97463316 with these inequalities . 103 129 W3136247815.pdf 22 5 separator 0.97742844 "¶ ¶" 131 141 W3136247815.pdf 22 0 bibliography 0.9981709 "Chinchilla, D., Zipfel, C., Robatzek, S., Kemmerling, B., Nürnberger, T., Jones, J. 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Plant Cell14, 1557 –1566. doi: 10.1105/tpc.002022" 2227 2442 W3048029420.pdf 14 21 separator 0.8939088 ¶ 2442 2444 W3048029420.pdf 14 22 bibliography 0.9981388 "Engelsdorf, T., Gigli-Bisceglia, N., Veerabagu, M., McKenna, J. F., Vaahtera, L., Augstein, F., et al. (2018). The plant cell wall integrity maintenance and immune signaling systems cooperate to control stress responses in Arabidopsis thaliana .Sci. Signal. 11 (536), pii: eaao3070. doi: 10.1126/scisignal.aao3070" 2444 2764 W3048029420.pdf 14 23 separator 0.9198886 ¶ 2764 2766 W3048029420.pdf 14 24 bibliography 0.99805087 "Escudero, V., Jorda ́, L., Sopeña-Torres, S., Me ́lida, H., Miedes, E., Muñoz-Barrios, A., et al. (2017). Alteration of cell wall xylan a cetylation triggers defense responses that counterbalance the immune de ficiencies of plants impaired in the b-subunit of the heterotrimeric G-protein. Plant J. 92, 386 –399. doi: 10.1111/tpj.13660" 2766 3107 W3048029420.pdf 14 25 separator 0.9185905 ¶ 3107 3109 W3048029420.pdf 14 26 bibliography 0.9981304 "Ferrari, S., Galletti, R., Pontiggia, D., Manfredini, C., Lionetti, V., Bellincampi, D., et al. (2008). Transgenic expression of a fungal endo-polygalacturonase increases plant resistance to pathogens and reduces auxin sensitivity. Plant Physiol. 146, 669 –681. doi: 10.1104/pp.107.109686" 3109 3404 W3048029420.pdf 14 27 separator 0.9186934 ¶ 3404 3406 W3048029420.pdf 14 28 bibliography 0.9980509 "Ferrari, S., Savatin, D. V., Sicilia, F., Gramegna, G., Cervone, F., and Lorenzo, G. (2013). Oligogalacturonides: plant damage-associated molecular patterns and regulators of growth and development. Front. Plant Sci. 4, 49. doi: 10.3389/ fpls.2013.00049" 3406 3666 W3048029420.pdf 14 29 separator 0.9197135 ¶ 3666 3668 W3048029420.pdf 14 30 bibliography 0.9981634 "Fischer, M. H., Yu, N., Gray, G. R., Ralph, J., Anderson, L., and Marlett, J. A. (2004). The gel-forming polysaccharide of psyllium husk ( Plantago ovata Forsk). Carbohydr. Res. 339, 2009 –2017. doi: 10.1016/j.carres.2004.05.023" 3668 3901 W3048029420.pdf 14 31 separator 0.9290751 ¶ 3901 3903 W3048029420.pdf 14 32 bibliography 0.998095 "Frazee, A. C., Pertea, G., Jaffe, A. E., Langmead, B., Salzberg, S. L., and Leek, J. T. (2015). Ballgown bridges the gap between transcriptome assembly and expression analysis. Nat. Biotechnol. 33, 243 –246. doi: 10.1038/nbt.3172" 3903 4137 W3048029420.pdf 14 33 separator 0.9334202 ¶ 4137 4139 W3048029420.pdf 14 34 bibliography 0.9976497 "Gallego-Giraldo, L., Liu, C., Pose-Albacete, S., Pattathil, S., Peralta, A. G., Young, J., et al. (2020). ARABIDOPSIS DEHISCENCE ZONE POLYGALACTURONASE 1 (ADPG1) releases latent defense signals in stems with reduced lignin content. Proc. Natl. Acad. Sci. U.S.A. 117, 3281 –3290. doi: 10.1073/pnas.1914422117" 4139 4453 W3048029420.pdf 14 35 separator 0.9462421 ¶ 4453 4455 W3048029420.pdf 14 36 bibliography 0.9981617 "Hamann, T., Bennett, M., Mans field, J., and Somerville, C. (2009). Identi fication of cell-wall stress as a hexose-dependent and osmosensitive regulator of plant responses. Plant J. 57, 1015 –1026. doi: 10.1111/j.1365-313X.2008.03744.x" 4455 4694 W3048029420.pdf 14 37 separator 0.9120333 ¶ 4694 4696 W3048029420.pdf 14 38 bibliography 0.99799275 "He ́loir, M. C., Adrian, M., Brule ́, D., Claverie, J., Cordelier, S., Daire, X., et al. (2019). Recognition of elicitors in grapevine: from MAMP and DAMP perception to induced resistance. Front. Plant Sci. 10, 1117. doi: 10.3389/ fpls.2019.01117" 4696 4949 W3048029420.pdf 14 39 separator 0.937899 ¶ 4949 4951 W3048029420.pdf 14 40 bibliography 0.9980866 "Herna ́ndez-Blanco, C., Feng, D. X., Hu, J., Sanchez-Vallet, A., Deslandes, L., Llorente, F., et al. (2007). Impairment of Cellulose Synthases Required forArabidopsis Secondary Cell Wall Formation Enhances Disease Resistance. Plant Cell 19, 890 –903. doi: 10.1105/tpc.106.048058" 4951 5234 W3048029420.pdf 14 41 separator 0.91487813 ¶ 5234 5236 W3048029420.pdf 14 42 bibliography 0.99809855 "Houston, K., Tucker, M. R., Chowdhury, J., Shirley, N., and Little, A. (2016). The plant cell wall: a complex and dynamic structure as revealed by the responses of genes under stress conditions. Front. Plant Sci. 7, 984. doi: 10.3389/ fpls.2016.00984" 5236 5493 W3048029420.pdf 14 43 separator 0.925719 ¶ 5493 5495 W3048029420.pdf 14 44 bibliography 0.9981038 "Johnson, J. M., Thürich, J., Petutschnig, E. K., Altschmied, L., Meichsner, D., Sherameti, I., et al. (2018). Poly(A) ribonuclease controls the cellotriose-based interaction between Piriformospora indica and its host Arabidopsis. Plant Physiol. 176, 2496 –2514. doi: 10.1104/pp.17.01423" 5495 5788 W3048029420.pdf 14 45 separator 0.91304827 ¶ 5788 5790 W3048029420.pdf 14 46 bibliography 0.99815077 "Kim, D., Paggi, J. M., Park, C., Bennett, C., and Salzberg, S. L. (2019). Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotech. 37, 907 –915. doi: 10.1038/s41587-019-0201-4" 5790 6003 W3048029420.pdf 14 47 separator 0.91202533 ¶ 6003 6005 W3048029420.pdf 14 48 bibliography 0.9981123 "Li, Q., Wang, C., and Mou, Z. (2020). Perception of Damaged Self in Plants. Plant Physiol. 182, 1545 –1565. doi: 10.1104/pp.19.01242" 6005 6140 W3048029420.pdf 14 49 separator 0.89911944 ¶ 6140 6142 W3048029420.pdf 14 50 bibliography 0.9980024 "Lionetti, V., Fabri, E., De Caroli, M., Hansen, A. R., Willats, W. G. T., Piro, G., et al. (2017). Three pectin methylesterase inhibitors protect cell wall integrity for Arabidopsis immunity to Botrytis. Plant Physiol. 173, 1844 –1863. doi: 10.1104/ pp.16.01185" 6142 6410 W3048029420.pdf 14 51 separator 0.9203998 ¶ 6410 6412 W3048029420.pdf 14 52 bibliography 0.99812996 "Liu, T., Liu, Z., Song, C., Hu, Y., Han, Z., She, J., et al. (2012). Chitin-Induced Dimerization Activates a Plant Immune Receptor. Science 336, 1160 –1164. doi: 10.1126/science.1218867" 6412 6602 W3048029420.pdf 14 53 separator 0.9137381 ¶ 6602 6604 W3048029420.pdf 14 54 bibliography 0.99790925 "Llorente, F., Alonso-Blanco, C., Sa ́nchez-Rodr ı ́guez, C., Jorda, L., and Molina, A. (2005). ERECTA receptor-like kinase and heterotrimeric G protein from Arabidopsis are required for resis tance to the necrotrophic fungus Plectosphaerella cucumerina. Plant J. 43, 165 –180. doi: 10.1111/j.1365- 313X.2005.02440.x" 6604 6928 W3048029420.pdf 14 55 separator 0.8890908 ¶ 6928 6930 W3048029420.pdf 14 56 bibliography 0.9979067 "Locci, F., Benedetti, M., Pontiggia, D., Citterico, M., Caprari, C., Mattei, B., et al. (2019). An Arabidopsis berberine bridge enzyme-like protein speci fically oxidizes cellulose oligomers and plays a role in immunity. Plant J. 98, 540 – 554. doi: 10.1111/tpj.14237" 6930 7203 W3048029420.pdf 14 57 separator 0.9177111 ¶ 7203 7205 W3048029420.pdf 14 58 bibliography 0.9978763 "McCleary, B. V., McKie, V. A., Draga, A., Rooney, E., Mangan, D., and Larkin, J. (2015). Hydrolysis of wheat flour arabinoxylan, acid-debranched wheat flour arabinoxylan and arabino-xylo-oligosaccharides by b-xylanase, a-L- arabinofuranosidase and b-xylosidase. Carbohydr. Res. 407, 79 –96. doi: 10.1016/j.carres.2015.01.017" 7205 7536 W3048029420.pdf 14 59 separator 0.9500337 ¶ 7536 7538 W3048029420.pdf 14 60 bibliography 0.99808854 "Me ́lida, H., Largo-Gosens, A., Novo-Uzal, E., Santiago, R., Pomar, F., Garc ı ́a, P., et al. (2015). Ectopic ligni fication in primary cellulose-de ficient cell walls of maize cell suspension cultures. J. Integr. Plant Biol. 57, 357 –372. doi: 10.1111/ jipb.12346" 7538 7807 W3048029420.pdf 14 61 separator 0.95023406 ¶ 7807 7809 W3048029420.pdf 14 62 bibliography 0.99808073 "Me ́lida, H., Sopeña-Torres, S., Bacete, L., Garrido-Arandia, M., Jorda ́,L . ,L o ́pez, G., et al. (2018). Non-branched b-1,3-glucan oligosaccharides trigger immune responses in Arabidopsis. Plant J. 93, 34 –49. doi: 10.1111/tpj.13755" 7809 8049 W3048029420.pdf 14 63 separator 0.95307124 ¶ 8049 8051 W3048029420.pdf 14 64 bibliography 0.9980281 "Miedes, E., Vanholme, R., Boerjan, W., and Molina, A. (2014). The role of the secondary cell wall in plant resistance to pathogens. Front. Plant Sci. 5, 358x. doi: 10.3389/fpls.2014.00358" 8051 8243 W3048029420.pdf 14 65 separator 0.9376999 ¶ 8243 8245 W3048029420.pdf 14 66 bibliography 0.99791956 "Molina, A., Miedes, E., Bacete, L., Rodr ı ́guez, T., Me ́lida, H., Denance ́, N., et al. (2020). Arabidopsis cell wall composition determines disease resistance specificity and fitness. bioRxiv . doi: 10.1101/2020.05.21.105650" 8245 8475 W3048029420.pdf 14 67 separator 0.9514265 ¶ 8475 8477 W3048029420.pdf 14 68 bibliography 0.9980324 "Mort, A. J., Moerschbacher, B. M., Pierce, M. L., and Maness, N. O. (1991). Problems encountered during the extraction, puri fication, and chromatography of pectic fragments, and some solutions to them. Carbohydr. Res. 215, 219 –227. doi: 10.1016/0008-6215(91)84022-7" 8477 8750 W3048029420.pdf 14 69 separator 0.9598527 ¶ 8750 8752 W3048029420.pdf 14 70 bibliography 0.9981419 "Nafisi, M., Fimognari, L., and Sakuragi, Y. (2015). Interplays between the cell wall and phytohormones in interaction between plants and necrotrophicpathogens. Phytochemistry 112, 63 –71. doi: 10.1016/j.phytochem.2014.11.008" 8752 8978 W3048029420.pdf 14 71 separator 0.95846194 ¶ 8978 8980 W3048029420.pdf 14 72 bibliography 0.99806756 "Naran, R., Chen, G., and Carpita, N. C. (2008). Novel rhamnogalacturonan I and arabinoxylan polysaccharides of flax seed mucilage. Plant Physiol. 148, 132 – 141. doi: 10.1104/pp.108.123513" 8980 9172 W3048029420.pdf 14 73 separator 0.92471826 ¶ 9172 9174 W3048029420.pdf 14 74 bibliography 0.9980975 "Nothnagel, E. A., McNeil, M., Albersheim, P., and Dell, A. (1983). Host-Pathogen Interactions: XXII. A galacturonic acid oligosaccharide from plant cell walls elicits phytoalexins. Plant Physiol. 71, 916 –926. doi: 10.1104/pp.71.4.916" 9174 9413 W3048029420.pdf 14 75 separator 0.96811795 ¶ 9413 9415 W3048029420.pdf 14 76 bibliography 0.996717 "P e r t e a ,M . ,P e r t e a ,G .M . ,A n t o n e s c u ,C .M . ,C h a n g ,T .C . ,M e n d e l l ,J .T . ,a n dS a l z b e r g , S. L. (2015). StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nat. Biotechnol. 33, 290 –295. doi: 10.1038/nbt.3122" 9415 9698 W3048029420.pdf 14 77 separator 0.93798846 ¶ 9698 9700 W3048029420.pdf 14 78 bibliography 0.9973855 "Pertea, M., Kim, D., Pertea, G. M., Leek, J. T., and Salzberg, S. L. (2016). Transcript- level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown. Nat. Protoc. 11, 1650 –1667. doi: 10.1038/nprot.2016.095Me ́lida et al. Arabinoxylan-Oligosaccharides as Plant DAMPs" 9700 9994 W3048029420.pdf 14 79 separator 0.7768535 ¶ 9994 9996 W3048029420.pdf 14 80 paratext 0.97476816 Frontiers in Plant Science | www.frontiersin.org August 2020 | Volume 11 | Article 1210 15 9996 10087 W3048029420.pdf 14 0 paratext 0.98570794 Page 7/17 0 9 W3081396715.pdf 6 1 title 0.96350527 Category Criteria 9 27 W3081396715.pdf 6 2 separator 0.99485767 ¶ 29 31 W3081396715.pdf 6 3 text 0.8919475 Study population Adults (≥18 years old) living in nursing homes 31 95 W3081396715.pdf 6 4 separator 0.8791758 ¶ ¶ 96 102 W3081396715.pdf 6 5 text 0.78946453 Language English and Chinese 102 131 W3081396715.pdf 6 6 separator 0.8882387 ¶ 131 133 W3081396715.pdf 6 7 text 0.90086997 "Intervention/health solutionTechnology-based interventions (e.g., digital tools such as smartphones and tablets, sensor devices, internet-based programs)" 133 291 W3081396715.pdf 6 8 separator 0.97047615 ¶ ¶ 291 297 W3081396715.pdf 6 9 text 0.9949657 "Key variable Detailed descriptions of the technology-based interventions (i.e., purpose of the intervention (to evaluate the aims of existing interventions), use of technology (to examine how different types of technologies have been applied among nursing home residents), application of the interventions (to investigate the degree to which the interventions have involved nursing home residents in the adoption/application of technologies), intervention exposure (to study how different interventions have been used among nursing home residents), outcome variables assessed/measured (to evaluate the quantifiable outcomes of technology-based interventions), and weather the design of the intervention material is tailored to nursing home residents (to examine to degree to which the design technology-based interventions has taken the unique attributes of nursing home residents into consideration)" 297 1224 W3081396715.pdf 6 10 separator 0.97519016 ¶ ¶ 1224 1230 W3081396715.pdf 6 11 text 0.86008036 "Study type Original research (i.e., research that reports original and empirical research findings) ¶ Study design Randomized controlled trials ¶ Study outcome Empirical reporting of the effect of the intervention (i.e., qualitative designs excluded)" 1230 1497 W3081396715.pdf 6 12 separator 0.9968388 ¶ 1497 1499 W3081396715.pdf 6 13 title 0.9876743 Search strategy 1499 1515 W3081396715.pdf 6 14 separator 0.9953819 ¶ 1515 1517 W3081396715.pdf 6 15 text 0.9993959 "Databases including PubMed, PsycINFO, CINAHL, and Scopus, will be searched for eligible articles. We will also search ProQuest Dissertations to examine gray literature sources. A search strategy was developed in consultation with a librarian experienced in systematic review methods. Search terms used to locate articles will center on three concepts: nursing home residents, technology-based interventions, and randomized controlled trials. An example PubMed search string is illustrated in Table 2." 1517 2026 W3081396715.pdf 6 16 separator 0.9969338 ¶ 2026 2028 W3081396715.pdf 6 17 caption 0.8746345 Table 2. Example PubMed search string 2028 2066 W3081396715.pdf 6 0 paratext 0.9847192 Int. J. Environ. Res. Public Health 2013 , 10 3767 0 50 W2004978413.pdf 14 1 separator 0.9640515 ¶ ¶ 52 58 W2004978413.pdf 14 2 bibliography 0.99741113 "13. Paraskevaides, T. ; Morgan, C .J.; Leits, J .R.; Bisby, J .A.; Rendell, P.G. ; Curran, V. Drinking and future thinking: Acute effects of alcohol on prospective memory and future simulation. Psychopharmacology 2010 , 208, 301 –308." 59 302 W2004978413.pdf 14 3 separator 0.9764829 ¶ 303 305 W2004978413.pdf 14 4 bibliography 0.99767506 "14. Maurage, P. ; Grynberg, D. ; Noë l, X. ; Joassin, F. D.R.; Hanak, C. ; Verbanck, P. ; Luminet, O.; Timary, P. ; Campanella, S. ; Philippot, P. The ―Reading the Mind in the Eyes‖ test as a new way to explore complex emotions decoding in alcohol dependence. Psychiatry Res. 2011 , 190, 375–378." 305 617 W2004978413.pdf 14 5 separator 0.9777607 ¶ 618 620 W2004978413.pdf 14 6 bibliography 0.99806434 "15. Thoma, P.; Friedmann , C.; Suchan, B. Empathy and social problem solving in alcohol dependence, mood disorders and selected personality disorders. Neurosci . Biobehav . Rev. 2013 , 37, 448 –470." 620 824 W2004978413.pdf 14 7 separator 0.9542647 ¶ 825 827 W2004978413.pdf 14 8 bibliography 0.99787194 "16. Uekermann, J. ; Daum, I. Social cognition in alcoholism: A link to prefrontal cortex dysfunction? Addiction 2008 , 103, 726 –735." 827 967 W2004978413.pdf 14 9 separator 0.95447254 ¶ 968 970 W2004978413.pdf 14 10 bibliography 0.99793005 "17. Giancola , P.R. The moderating effects of d ispositional empathy on alcohol related aggression in men and women. J. Abnorm . Psychol. 2003 , 112, 275 –281." 970 1135 W2004978413.pdf 14 11 separator 0.95898354 ¶ 1136 1138 W2004978413.pdf 14 12 bibliography 0.9979645 "18. Lisco , C.G.; Parrott , D.J.; Tharp , A.T. The role of heavy episodic drinking and hostile sexism in men’s sexual aggression toward female intimate partners. Addict . Behav. 2012 , 37, 1264 –1270 ." 1138 1345 W2004978413.pdf 14 13 separator 0.96117663 ¶ 1347 1349 W2004978413.pdf 14 14 bibliography 0.9980131 19. Cicchetti , D.; Toth , S.L. Child maltreatment. Annu . Rev. Clin. Psychol. 2005 , 1, 409 –438. 1349 1450 W2004978413.pdf 14 15 separator 0.9467399 ¶ 1452 1454 W2004978413.pdf 14 16 bibliography 0.9980148 "20. Mesa -Gresa , P.; Moya -Albiol , L. Neurobiology of child abuse: The ―cycle of violence ‖ (in Spanish) . Rev. Neurol. 2011 , 52, 489 –503." 1454 1602 W2004978413.pdf 14 17 separator 0.9617914 ¶ 1603 1605 W2004978413.pdf 14 18 bibliography 0.9979638 "21. Romero -Martí nez, A.; Moya -Albiol, L. Neuropsychology of perpetrators of domestic violence: The role of traumatic brain injury and alcohol abuse and/or dependence. Rev. Neurol. 2013, in press." 1605 1809 W2004978413.pdf 14 19 separator 0.9710312 ¶ 1812 1814 W2004978413.pdf 14 20 bibliography 0.9979033 "22. Kornhuber, J.; Erhard, G.; Lenz, B.; Kraus, K.; Sperling, W.; Bayerlein, K.; Biermann, T.; Stoessel, C. Low digit ra tio 2D:4D in alcohol depe ndent patie nts. PLoS One 2011 , 6, e19332 , doi:10.1371/journal.pone.0019332 ." 1814 2048 W2004978413.pdf 14 21 separator 0.9566374 ¶ 2049 2051 W2004978413.pdf 14 22 bibliography 0.9979616 "23. Manning, J.T.; Fink, B. Digit ratio, nicotine and alcohol intake and national rates of smoking and alcohol consumption . Pers. Ind. Diff. 2011 , 50, 344 –348." 2051 2217 W2004978413.pdf 14 23 separator 0.9647093 ¶ 2218 2220 W2004978413.pdf 14 24 bibliography 0.99792826 "24. Campbell, B.C.; Dreber, A.; Apicella , C.L.; Eisenberg , D.T.; Gray , P.B.; Little , A.C.; Garcia , J.R.; Zamore , R.S.; Lum , J.K. Testosterone exposure, dopaminergic reward, and sensation -seeking in young men. Physiol . Behav. 2010 , 99, 451 –456." 2220 2483 W2004978413.pdf 14 25 separator 0.9622282 ¶ 2484 2486 W2004978413.pdf 14 26 bibliography 0.997985 "25. Bailey, A.A.; Hurd, P.L. Finger length ratio (2 D:4D) cor relates with physical aggression in men but not in women. Biol. Psychol. 2005 , 68, 215 –222." 2486 2648 W2004978413.pdf 14 27 separator 0.9573351 ¶ 2650 2652 W2004978413.pdf 14 28 bibliography 0.99788314 "26. Manning , J.T.; Peters , M. Digit ratio (2D:4D) and hand preference for writing in the BBC internet study . Laterality 2009 , 14, 528 –540." 2652 2801 W2004978413.pdf 14 29 separator 0.96374047 ¶ 2802 2804 W2004978413.pdf 14 30 bibliography 0.99789673 "27. Ohlmeier , M.D.; Peters , K.; te Wildt , B.T.; Zedler , M.; Ziegenbein , M.; Wiese , B.; Emrich , H.M.; Schneider, U. Comorbidity of alcohol and substance dependence with attention -deficit/ hyperactivity disorder (ADHD). Alcohol Alcohol. 2008 , 43, 300 –304." 2804 3075 W2004978413.pdf 14 31 separator 0.9725871 ¶ 3076 3078 W2004978413.pdf 14 32 bibliography 0.99780184 "28. Lenz , B.; Jacob , C.; Frieling , H.; Jacobi , A.; Hillemacher , T.; Muschler , M.; Watson , K.; Kornhuber , J.; Bleich , S. Polymorphism of the long polyglutamine tract in the human androgen receptor influences craving of men in alcoholwithdraw al. Psychoneuroendocrinology 2009 , 34, 968–971." 3078 3388 W2004978413.pdf 14 33 separator 0.9650737 ¶ 3389 3391 W2004978413.pdf 14 34 bibliography 0.99792504 "29. Borkowska, B.; Pawlowski, B. Alcohol and nicotine intake and prenatal level of androgens measured by digit ratio. Pers. Ind. Diff. 2013 , 55, 685 –687." 3391 3550 W2004978413.pdf 14 0 paratext 0.9873612 Vol.:(0123456789)https://doi.org/10.1007/s42399-022-01312-z 0 59 W4306786652.pdf 0 1 separator 0.9778316 ¶ 59 61 W4306786652.pdf 0 2 title 0.9628775 CORRECTION 61 72 W4306786652.pdf 0 3 separator 0.97641665 ¶ 72 74 W4306786652.pdf 0 4 title 0.9691741 "Correction to: Pleomorphic Adenoma of Palatal Minor Salivary Glands with Bone Infiltration: Case Report with Long‐term Follow‐up" 74 206 W4306786652.pdf 0 5 separator 0.98722404 ¶ 206 208 W4306786652.pdf 0 6 contact 0.8491236 Antonios Tsekos1 · Dimitris Tatsis2 · Anastasia Fotiadou3 · Nikolaos Kechagias1 · Konstantinos Vahtsevanos1,2 208 319 W4306786652.pdf 0 7 separator 0.71082777 ¶ 319 324 W4306786652.pdf 0 8 paratext 0.9248228 "¶ © The Author(s) 2022 The original article can be found online at https:// doi. org/ 10. 1007/ s42399- 022- 01297-9" 324 448 W4306786652.pdf 0 9 separator 0.8952464 ¶ 448 450 W4306786652.pdf 0 10 contact 0.9949821 "* Dimitris T atsis dtatsis@outlook .com; dimitats@auth.gr" 451 513 W4306786652.pdf 0 11 separator 0.8994981 ¶ 513 515 W4306786652.pdf 0 12 contact 0.94023347 "1 Department of Oral & Maxillofacial Surgery, Clinic St. Louk as, Thessaloniki, Greece 2 Department of Oral & Maxillofacial Surgery, G. Papanikolaou General Hospital, 57010, Exochi, Thessaloniki, Greece 3 Pathologist, Private Practice, Thessaloniki, GreeceCorrection to: SN Comprehensive Clinical Medicine" 515 834 W4306786652.pdf 0 13 paratext 0.90460104 "(2022) 4:215 https://doi.org/10.1007/s42399-022-01297-9" 834 892 W4306786652.pdf 0 14 separator 0.9888538 ¶ 892 894 W4306786652.pdf 0 15 text 0.6320083 "The article “Pleomorphic Adenoma of Palatal Minor Sali - var" 894 957 W4306786652.pdf 0 16 title 0.47028348 y 957 958 W4306786652.pdf 0 17 text 0.43427616 G 958 960 W4306786652.pdf 0 18 title 0.40406185 lands 960 965 W4306786652.pdf 0 19 text 0.8600141 "with Bone Infiltration: Case Report with Long- term Follow-up”, was originally published electronically on the publisher’s internet portal on 28 September 2022 with error in author group. and were interchanged in the published article. The original article has been corrected." 965 1280 W4306786652.pdf 0 20 separator 0.9614216 ¶ 1280 1282 W4306786652.pdf 0 21 paratext 0.86764586 "Open Access This article is licensed under a Cr eative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/." 1282 2179 W4306786652.pdf 0 22 separator 0.96988356 ¶ 2179 2181 W4306786652.pdf 0 23 paratext 0.6164858 Publisher’s Note Spring er Nature 2181 2216 W4306786652.pdf 0 24 text 0.4399478 "remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 2216 2322 W4306786652.pdf 0 25 paratext 0.91078377 Published online: 19 October 2022SN Comprehensive Clinical Medicine (2022) 4:229 2322 2402 W4306786652.pdf 0 0 paratext 0.84286124 170 E. A. DALY ---- 0 19 W2332495948.pdf 17 1 title 0.94247633 TIIK EVOLUTION OF T H E LIM ESTONES 19 55 W2332495948.pdf 17 2 separator 0.9848926 ¶ 55 57 W2332495948.pdf 17 3 text 0.9995493 "accumulate not earlier than the Devonian period. The calcium did not begin to accumulate in similar excess until the general scavenging system was established in the “bathybial” (not “abyssal” ) regions of the ocean floor—perhaps as late as the Cretaceous period. When we also bear in mind that the sodium and potassium salts have been slowly accumulating from the pre-Cambrian to the present time, we are prepared to reach the rather probable conclusion that the pre-Cambrian ocean really approx­ imated a fresh-water (though, perhaps, faintly acid) condition. The only escape from that conclusion seems to be offered in the view that a large part of the existing ocean is made of nearly pure “juvenile” water emitted from volcanic vents or from primary igneous rocks since the pre- Cambrian." 57 893 W2332495948.pdf 17 4 separator 0.98145926 ¶ 893 895 W2332495948.pdf 17 5 text 0.9996844 "The actual calculation of about 900 typical analyses confirms the pre­ vailing view that the Paleozoic and pre-Paleozoic limestones are more highly magnesian than the more recent limestones. The ratio of calcium to magnesium is nearly constant in the average limestones of the pre- Cambrian, Cambrian, Ordovician, and Silurian formations. That ratio rises abruptly in the average Devonian limestone and increases again greatly in the average Carboniferous limestone. In the Cretaceous lime­ stones it reaches a maximum value which is very close to, or sensibly equal to, that characteristic of the average Tertiary and Recent lime­ stones." 895 1565 W2332495948.pdf 17 6 separator 0.9817052 ¶ 1565 1567 W2332495948.pdf 17 7 text 0.9996953 "Detailed field work and microscopic and chemical study have indicated that the higher proportions of magnesium in the older limestones can not be explained by their having been more deeply buried and more meta­ morphosed than the younger limestones. The evidence shows that the magnesian content of the staple pre-Devonian limestone is original, in the sense that the magnesium carbonate was precipitated from sea-water. In many, if not all, cases the dolomite crystals may have been formed at or near the surface of the ancient calcareous muds by the interaction of the magnesian salts of the sea-water with the more easily precipitated calcium carbonate. Porosity of the sea bottom would aid this process, as it is today favoring the dolomitization of certain more porous beds in the Funafuti atoll." 1567 2411 W2332495948.pdf 17 8 separator 0.9809241 ¶ 2411 2413 W2332495948.pdf 17 9 text 0.9996133 "In brief, the chemical composition of the ocean water, the conditions of life in the sea, and the marine limestones in general have all had a correlative evolution. The hypothesis founded on this central thought is at many points in this paper strongly charged with speculation; each item of speculation is offered not only as a means of intelligently group­ ing the many facts relating to this important theme, but also, and more especially, as an advertisement calling for new facts." 2413 2920 W2332495948.pdf 17 10 separator 0.8849689 ¶ 2920 2922 W2332495948.pdf 17 11 paratext 0.9651004 on November 1, 2015 gsabulletin.gsapubs.org Downloaded from 2923 2983 W2332495948.pdf 17 0 paratext 0.97566783 ©1917 Nature Publishing Group 0 29 W1993846342.pdf 0 0 paratext 0.98387367 Materials 2023 ,16, 1958 14 of 16 0 33 W4323314639.pdf 13 1 separator 0.98714066 ¶ 33 35 W4323314639.pdf 13 2 bibliography 0.9976348 "5. Wang, X.; Fan, F.; Lai, J. Strength behavior of circular concrete-filled steel tube stub columns under axial compression: A review. Constr. Build. Mater. 2022 ,322, 126144. 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Multi-axis testing of concrete-filled steel tube columns forming ductile soft-story in multi-story buildings. J. Constr. Steel Res. 2021 ,183, 106736. [CrossRef]" 2033 2252 W4323314639.pdf 13 21 separator 0.81086814 ¶ 2252 2254 W4323314639.pdf 13 22 bibliography 0.99795675 "15. Zhang, D.; Li, N.; Zhang, S. Energy dissipation and resilience of precast segmented concrete-filled steel tube self-centering column: Parameter study and design methodology. Eng. Struct. 2021 ,244, 112747. [CrossRef]" 2254 2476 W4323314639.pdf 13 23 separator 0.8557118 ¶ 2476 2478 W4323314639.pdf 13 24 bibliography 0.9979572 "16. Yang, H.; Han, L.H.; Wang, Y.C. Effects of heating and loading histories on post-fire cooling behaviour of concrete-filled steel tubular columns. J. Constr. Steel Res. 2008 ,64, 556–570. [CrossRef]" 2478 2680 W4323314639.pdf 13 25 separator 0.83511126 ¶ 2680 2682 W4323314639.pdf 13 26 bibliography 0.9980055 "17. Meng, F.Q.; Zhu, M.C.; Clifton, G.C.; Ukanwa, K.U.; Lim, J.B. Performance of square steel-reinforced concrete-filled steel tubular columns subject to non-uniform fire. J. Constr. Steel Res. 2020 ,166, 105909. [CrossRef]" 2682 2906 W4323314639.pdf 13 27 separator 0.8615533 ¶ 2906 2908 W4323314639.pdf 13 28 bibliography 0.99786323 "18. Rahnavard, R.; Craveiro, H.D.; Sim ões, R.A.; Santiago, A. Equivalent temperature prediction for concrete-filled cold-formed steel (CF-CFS) built-up column sections (part A). Case Stud. Therm. Eng. 2022 ,33, 101928. [CrossRef]" 2908 3140 W4323314639.pdf 13 29 separator 0.7234324 ¶ 3140 3142 W4323314639.pdf 13 30 bibliography 0.9978231 "19. Rahnavard, R.; Craveiro, H.D.; Sim ões, R.A.; Santiago, A. Equivalent temperature prediction for concrete-filled cold-formed steel (CF-CFS) built-up column sections (part B). Case Stud. Therm. Eng. 2022 ,35, 102111. [CrossRef]" 3142 3374 W4323314639.pdf 13 31 separator 0.7902601 ¶ 3374 3376 W4323314639.pdf 13 32 bibliography 0.99799496 "20. Rahnavard, R.; Craveiro, H.D.; Simoes, R.A.; La ím, L.; Santiago, A. Fire resistance of concrete-filled cold-formed steel (CF-CFS) built-up short columns. J. Build. Eng. 2022 ,48, 103854. [CrossRef]" 3376 3580 W4323314639.pdf 13 33 separator 0.8931946 ¶ 3580 3582 W4323314639.pdf 13 34 bibliography 0.9979336 "21. Van Chanh, N. Steel Fiber Reinforced Concrete. In Seminar Material ; Faculty of Civil Engineering, University of Technology: Ho Chi Minh City, Vietnam, 2004; pp. 108–116." 3582 3759 W4323314639.pdf 13 35 separator 0.94179124 ¶ 3759 3761 W4323314639.pdf 13 36 bibliography 0.99795544 "22. Li, V .C. On engineered cementitious composites (ECC) a review of the material and its applications. J. Adv. Concr. Technol. 2003 ,1, 215–230. [CrossRef]" 3761 3921 W4323314639.pdf 13 37 separator 0.9143363 ¶ 3921 3923 W4323314639.pdf 13 38 bibliography 0.9980046 "23. Kunieda, M.; Rokugo, K. Recent progress on HPFRCC in Japan required performance and applications. J. Adv. Concr. Technol. 2006 ,4, 19–33. [CrossRef]" 3923 4078 W4323314639.pdf 13 39 separator 0.9009758 ¶ 4078 4080 W4323314639.pdf 13 40 bibliography 0.99790037 "24. Jun, P .; Mechtcherine, V . Behaviour of strain-hardening cement-based composites (SHCC) under monotonic and cyclic tensile loading: Part 1–experimental investigations. Cem. Concr. Compos. 2010 ,32, 801–809. [CrossRef]" 4080 4305 W4323314639.pdf 13 41 separator 0.84532225 ¶ 4305 4307 W4323314639.pdf 13 42 bibliography 0.99797946 "25. Yao, W.; Li, J.; Wu, K. Mechanical properties of hybrid fiber-reinforced concrete at low fiber volume fraction. Cem. Concr. Res. 2003 ,33, 27–30. [CrossRef]" 4307 4468 W4323314639.pdf 13 43 separator 0.8522911 ¶ 4468 4470 W4323314639.pdf 13 44 bibliography 0.99802244 26. Soroushian, P .; Bayasi, Z. Fiber type effects on the performance of steel fiber reinforced concrete. Mater. J. 1991 ,88, 129–134. 4470 4604 W4323314639.pdf 13 45 separator 0.92085314 ¶ 4604 4606 W4323314639.pdf 13 46 bibliography 0.9979261 "27. Zhao, P .; Huang, Y.; Liu, Z.; Wang, H.; Lu, Y. Experimental research on seismic performance of steel fiber-reinforced recycled concrete-filled circular steel tube columns. J. Build. Eng. 2022 ,54, 104683. [CrossRef]" 4606 4827 W4323314639.pdf 13 47 separator 0.8535383 ¶ 4827 4829 W4323314639.pdf 13 48 bibliography 0.99792534 "28. Kong, W.; Zhou, W.; Chen, L.; Liao, Q.; Zhu, Y.; Chen, Y. Flexural performance of steel fiber reinforced concrete filled stainless steel tubular trusses. Compos. Struct. 2023 ,303, 116266. [CrossRef]" 4829 5033 W4323314639.pdf 13 49 separator 0.79671633 ¶ 5033 5035 W4323314639.pdf 13 50 bibliography 0.9978688 "29. Zong, S.; Lu, Y.; Ma, W.; Yan, Y.; Lin, C. Behaviour of steel-fibre-reinforced recycled concrete-filled square steel tubular short columns under axial compressive load. Eng. Struct. 2022 ,271, 114894. [CrossRef]" 5035 5251 W4323314639.pdf 13 51 separator 0.8093951 ¶ 5251 5253 W4323314639.pdf 13 52 bibliography 0.99798894 "30. Li, T.; Ran, J.; Chen, D.; Du, Y.; Zhu, Q.; Zhang, H.; Li, W. Structural behaviors of steel fiber-reinforced concrete-filled geotextile tube stub columns under axial compression. In Structures ; Elsevier: Amsterdam, The Netherlands, 2022; Volume 40, pp. 434–447." 5253 5520 W4323314639.pdf 13 53 separator 0.94692373 ¶ 5520 5522 W4323314639.pdf 13 54 bibliography 0.9977581 "31. Liu, Z.; Huang, D.; Lu, Y.; Li, S. Eccentric loading behavior of steel tube columns filled with steel-fiber-reinforced recycled concrete. Struct. Concr. 2022 . [CrossRef]" 5522 5697 W4323314639.pdf 13 55 separator 0.8089806 ¶ 5697 5699 W4323314639.pdf 13 56 bibliography 0.99801385 "32. Naji, A.J.; Al-Jelawy, H.M.; Hassoon, A.; Al-Rumaithi, A. Axial Behavior of Concrete Filled-steel Tube Columns Reinforced with Steel Fibers. Int. J. Eng. 2022 ,35, 1682–1689. [CrossRef]" 5699 5891 W4323314639.pdf 13 57 separator 0.8765389 ¶ 5891 5893 W4323314639.pdf 13 58 bibliography 0.99803615 "33. Karalar, M.; Özkılıç, Y.O.; Deifalla, A.F.; Aksoylu, C.; Arslan, M.H.; Ahmad, M.; Sabri, M.M.S. Improvement in bending performance of reinforced concrete beams produced with waste lathe scraps. Sustainability 2022 ,14, 12660. [CrossRef]" 5893 6136 W4323314639.pdf 13 0 paratext 0.9861528 Page 3/11 0 9 W4306176574.pdf 2 1 text 0.9973141 "Transmission of infections and its severity can be controlled with good hygienic practices, and proper knowledge of use of gloves, protective clothing and alcohol based hand rubs and invasive procedures5. In addition to that, transmission of infection can be prevented through following guidelines regarding infection control, adhering to the standard precautions, continuing proper education and arranging updated training facilities for health care professionals1,6." 9 485 W4306176574.pdf 2 2 separator 0.96273744 ¶ 485 487 W4306176574.pdf 2 3 text 0.9986766 "In Sri Lanka multidisciplinary teams are working together to take care of patients and these hospital environments provide a favorable transmission pathway for nosocomial infections, due to poor practices of infection control among health care workers as well as overcrowding of patients in most clinical settings5." 487 807 W4306176574.pdf 2 4 separator 0.92478186 ¶ 807 809 W4306176574.pdf 2 5 text 0.99711406 Physiotherapists also play a signi 809 844 W4306176574.pdf 2 0 paratext 0.98497 E3S Web of Conferences 0 22 W2136981850.pdf 3 1 separator 0.97206914 ¶ ¶ 24 30 W2136981850.pdf 3 2 text 0.99822444 "In this case, the maximum loading capacity of Cu is 185 mg/kg (200 subtracts 15) and Zn is 551 mg/kg (600 subtracts 49). Considering 2000 ton/ha soil in the agricultural soils (top soil 15 cm depth), the Maximum loading capacity of metals in soil f or Cu is 370 kg/ha and Zn is 1102 kg/ha. Maximum application rate of compost can be calculated as followings:" 31 411 W2136981850.pdf 3 3 separator 0.95097697 ¶ ¶ 413 419 W2136981850.pdf 3 4 math 0.8234601 "Maximum application rate (ton/ha ) = [Maximum loading capacity of metals in soil (kg/ha) / heavy metal concentration in the compost (mg /kg)] × 1000" 419 576 W2136981850.pdf 3 5 separator 0.86862135 ¶ ¶ 578 584 W2136981850.pdf 3 6 text 0.9986558 "For example, the compost F with Zn 1213 mg/kg, and the maximum application rate is thus 908 ton/ha. This implied that at the application rate of 40 ton/ha/year, it will take 22 years of application to increase the total Zn concentration in soils to reach the regulation standard." 584 881 W2136981850.pdf 3 7 separator 0.9970753 ¶ 883 885 W2136981850.pdf 3 8 title 0.9874191 Conclusion 886 897 W2136981850.pdf 3 9 separator 0.9970208 ¶ 899 901 W2136981850.pdf 3 10 text 0.9994743 "Manure c ompost with the large range of Cu (34 -560 mg/kg) and Zn (104 -1213 mg/kg) concentration were applied at 20, 40, and 80 ton/ha/year. Both the yield of the pokchoi (leaves vegetable) and rice grain w ere enhanced by the application of manure compost. T he yield of rice grain was further increased at hig her application rate. The Cu and Zn concentration of crops were slightly increased by the application of manure compost, but they were still acceptable, pakchoi (Cu: 1.8-10.4 mg/kg; Zn: 39-160 mg/kg ), rice grain (Cu: 0.6-4.0 mg/kg; Zn: 58 -79 mg/kg) . The mobility of Cu and Zn of the paddy soil w as decreased, while the soil bioavailability of Zn was increased in the compost treatment s in the rural soil. Our evaluation indicated that the t otal Zn concentration of soils may reach the regulation standard after 2 2 years of manure compost application by the application rate of 40 ton/ha/year." 902 1868 W2136981850.pdf 3 11 separator 0.99358463 ¶ ¶ 1870 1876 W2136981850.pdf 3 12 title 0.900972 References 1876 1887 W2136981850.pdf 3 13 separator 0.9916277 ¶ ¶ 1889 1895 W2136981850.pdf 3 14 bibliography 0.99647844 "Chen ZS, Hseu ZY. Total organic pool in soils of Taiwan . In: Proceedings of the National Science Council, Taiwan, 1997, Part B: life sciences, Vol. 21, no. 3, pp. 120-127." 1895 2079 W2136981850.pdf 3 15 separator 0.98724234 ¶ 2080 2082 W2136981850.pdf 3 16 bibliography 0.9974567 "Diez JA, de la Torre AI, Cartagena MC, Carballo M, Vallejo A, Munoz MJ. Evaluation of the application of pig slurry to an experimental crop using agronomic a nd ecotoxicological approaches. J Environ Qual 2001; 30:2165– 2172." 2082 2322 W2136981850.pdf 3 17 separator 0.9712851 ¶ 2324 2326 W2136981850.pdf 3 18 bibliography 0.99753916 "Epstein E. The science of composting. Technomic , 1997, Publishing Co. Inc., Lancaster, Pennsylvania 17604, USA." 2326 2443 W2136981850.pdf 3 19 separator 0.9641618 ¶ 2445 2447 W2136981850.pdf 3 20 bibliography 0.997662 "Hseu ZY. Evaluating heavy metal contents in nine compost using four digestion methods. Bioresources Technol 2004 ; 95:53 -59." 2447 2580 W2136981850.pdf 3 21 separator 0.98539484 ¶ 2581 2583 W2136981850.pdf 3 22 bibliography 0.99773026 "Kabata -Pendias A, Pendias H . Trace Elements in Soils and Plants. 2001. p.106- 118. 3rd ed. CRC press, Florida, USA." 2583 2709 W2136981850.pdf 3 23 separator 0.9848429 ¶ 2711 2713 W2136981850.pdf 3 24 bibliography 0.9808764 "Lin HT, Weng ZS, Lee GC . The concentration of heavy metal in food and the regulation act. 2002. Taiwan Agricultural Chemicals and Toxic Substances Research Institute (TACTRI) , Council of Agriculture, Taiwan ." 2713 2939 W2136981850.pdf 3 25 separator 0.98428744 ¶ 2941 2943 W2136981850.pdf 3 26 bibliography 0.99698657 "Shu YY, Chung RS. Rice growth and nutrient accumulation as affected by different compost . Commun Soil Sci Plant Anal 2006 ; 37:1139- 1156." 2943 3089 W2136981850.pdf 3 27 separator 0.98251116 ¶ 3091 3093 W2136981850.pdf 3 28 bibliography 0.9971833 "Zhou DM , Hao XZ, Wang YJ, Dong YH, Cang L. Copper and Zn uptake by radish and pakchoi as affected by application of livestock and poultry manures . Chemosphere 2005; 59:167- 175." 3093 3287 W2136981850.pdf 3 29 separator 0.98090005 ¶ ¶ 3288 3294 W2136981850.pdf 3 30 paratext 0.67230684 15008-p.4 3294 3304 W2136981850.pdf 3 0 paratext 0.9757234 "Jurnal Ilmiah Ekonomi Islam, 10 (01), 2024, 131 Jurnal Ilmiah Ekonomi Islam, ISSN: 2477 -6157 ; E-ISSN 2579 -6534" 0 116 W4393341214.pdf 1 1 text 0.9687794 "keuangan secara keseutuhan melalui pembatasan risiko sistematis. Kebijakan ini dapat mencakup persyaratan modal yang lebih ketat, batasan kredit tertentu, dan peraturan yang mengharuskan lembaga keuangan memonitor dan melaporkan risiko kredit mereka dengan lebih ketat (Campos, 2019) ." 117 419 W4393341214.pdf 1 2 separator 0.95660543 ¶ 420 422 W4393341214.pdf 1 3 text 0.9991713 "Selanjutnya dipercaya bahwa kebijakan moneter dapat me nguasai perekonomian melalui pe rmintaan kredit dari sektor perbankan atau saluran pinjaman bank. Kebijakan moneter yang melibatkan mekanisme saluran kredit dapat memengaruhi efisiensi pasar keuangan dan kemampuan untuk memenuhi kebutuhan peminjam dan pemberi pinjaman. Ini juga memengaruhi seber apa banyak peminjam yang menghadapi penjatahan di pasar kredit. Efek kredit dalam kebijakan moneter memainkan peran diantara pihak yang saling berhubungan dengan kredit karena ketidaksempurnaan informasi. (Mahrous et al., 2020) ." 422 1037 W4393341214.pdf 1 4 separator 0.98409885 ¶ 1039 1041 W4393341214.pdf 1 5 text 0.9894348 "Berkaca dari krisis keuangan di Indone sia pada akhir tahun 2008 kian diakibatkan oleh sektor keuangan daripada faktor -faktor ekonomi yang tidak stabil baik dari internal maupun eksternal. Pada saat krisis terjadi, sektor keuangan Indonesia tidak memiliki kemampuan untuk memperkirakan , meminimalkan, dan mengupayakan risiko operasinya, yang mengakibatkan prosiklikalitas yang berlebihan. Ini menyebabkan pertumbuhan ekonomi lebih cepat selama perio de pertumbuhan (upturn) dan penurunan lebih cepat selama periode kontraksi (downturn) " 1041 1613 W4393341214.pdf 1 6 separator 0.5668785 ¶ 1613 1614 W4393341214.pdf 1 7 text 0.95151496 (Swaningrum, 2014 dalam Nuryana, 2017 : 57) . 1614 1660 W4393341214.pdf 1 8 separator 0.9969088 ¶ 1661 1663 W4393341214.pdf 1 9 caption 0.9925743 Gambar 1. Prakiraan Pertumbuhan Kredit dan Prakiraan Pertumbuhan DPK (Dana Pihak Ketiga) 1663 1753 W4393341214.pdf 1 10 separator 0.9849628 ¶ ¶ 1755 1761 W4393341214.pdf 1 11 caption 0.8571761 Sumber Data : Survei Perbankan, Bank Indonesia (2022) 1761 1815 W4393341214.pdf 1 12 separator 0.99153244 ¶ 1817 1819 W4393341214.pdf 1 13 text 0.99818677 "Berdasarkan prakiraan grafik gambar 1 di atas, Hasil survei menunjukkan bahwa responden masih optimistis tentang pertumbuhan kredit di masa mendatang. Mereka m emprediksi pertumbuhan kredit pada tahun 20 22 sebesar 9,3% (yoy), naik dari pertumbuhan 5,2 % (yoy) pada tahun 2021 (Grafik 11). Situasi moneter dan ekonomi, serta risiko penyaluran kredit yang relatif kecil, mendorong optimisme ini." 1819 2238 W4393341214.pdf 1 14 separator 0.936586 ¶ 2240 2242 W4393341214.pdf 1 15 text 0.9992648 "Menurut Survei Perbankan (2022) memaparkan bahwa pertumbuhan DPK diproyeksikan tetap stabil pada tahun 2022. Ini ditunjukkan oleh SBT prakiraan penghimpunan DPK tahun 2022 sebesar 60,1%, yang merupakan peningkatan yang positif meskipun tidak setinggi SBT 78,5% pada tahun sebelumnya (Grafik 12). Kondisi likuiditas bank y ang lebih baik serta peningkatan fasilitas dan layanan yang ditawarkan oleh bank adalah beberapa faktor yang mendorong optimisme perkiraan pertumbuhan DPK tersebut." 2242 2756 W4393341214.pdf 1 16 separator 0.97927344 ¶ 2758 2760 W4393341214.pdf 1 17 text 0.99943346 "Kenaikan kredit secara intensif , terutama kredit konsumsi, dapat menyebabkan overheating ka rena permintaan efektif melebihi output yang dapat dicapai. Pinjaman tersebut akan gagal bayar karena meningkatnya kepercayaan bank terhadap kemampuan nasabahnya untuk membayar dan kurangnya perhatian mereka saat memberikan kredit kepada kelompok berisiko tinggi (Anwar et al., 2023) ." 2760 3158 W4393341214.pdf 1 18 separator 0.9641193 ¶ 3159 3161 W4393341214.pdf 1 19 text 0.99838257 "Kepercayaan nasabah bagian dari kunci keberlangsung an bisnis dalam perbankan termasuk dalam bank umum syariah. Selain itu, pengawasan bank dimaksudkan untuk memastikan bahwa bank berfungsi sebagai lembaga intermediary dan mediator kebijakan moneter (Bank Indonesia, 2021) ." 3161 3452 W4393341214.pdf 1 20 separator 0.9807943 ¶ 3453 3455 W4393341214.pdf 1 21 text 0.99896455 "Akibat dari kejadian krisis tersebut, perhatian global economist tertuju pada kebijakan ekonomi negara, yaitu kestabilan ekonomi dan kemampuan untuk bertahan dari krisis. Oleh karena itu, penting untuk memastikan bahwa adanya kebijakan makroekonomi dan mon eter yang kuat, serta kebijakan makroprudensial dilaksanakan sesuai dengan tujuan dan dibidik dengan strategi yang tepat untuk menjaga stabilitas ekonomi baik di dalam maupun di luar, terutama dalam situasi di mana krisis sedang terjadi." 3455 3982 W4393341214.pdf 1 22 separator 0.9168285 ¶ 3984 3986 W4393341214.pdf 1 23 text 0.99325025 "Beberapa peneliti an telah membahas mengenai pengaruh kebijakan moneter dan makroprudensial" 3986 4081 W4393341214.pdf 1 24 separator 0.99421066 ¶ 4082 4084 W4393341214.pdf 1 0 text 0.9967066 "H2O2generation byirradiating blue light wasshowed. RLU increased asthenumber of photons increased. At1.0×1018photonsm-2s-1,405nmshowed thehighest RLU (3.9×107)." 0 164 W2809285525.pdf 12 1 separator 0.67395705 ¶ 164 166 W2809285525.pdf 12 2 text 0.9985601 "At5.0×1018photonsm-2s-1,439nmshowed thehighest RLU (4.06×107).At10.0×1018 photonsm-2s-1,439nmshowed thehighest RLU (5.58×107)." 166 299 W2809285525.pdf 12 3 separator 0.89579 ¶ 299 301 W2809285525.pdf 12 4 text 0.9990644 "Tocompare differences inthegeneration ofH2O2between wavelengths, multiple compari- sons were carried outat10.0×1018photonsm-2s-1(Fig 8)." 301 442 W2809285525.pdf 12 5 separator 0.8564396 ¶ 442 444 W2809285525.pdf 12 6 text 0.99927783 "The RLU showed that 405±466 nmwassignificantly higher than 494nm. The wavelength of439nmhadthehighest RLU." 444 553 W2809285525.pdf 12 7 separator 0.9961339 ¶ 553 555 W2809285525.pdf 12 8 title 0.9875286 Discussion 555 566 W2809285525.pdf 12 9 separator 0.9944547 ¶ 566 568 W2809285525.pdf 12 10 text 0.9877323 "This study confirmed that blue light islethal toallgrowth stages ofD.enamgotms-nr. The inner space ofthePetri dish didnotregister temperatures that would have affected the survival atanyofthedevelopmental stages inanyoftheirradiation treatments (S6±S9 Tables). Inaddition, theriseinmortality didnotalways correspond toariseintemperature. Thus, we concluded that ariseintemperature caused bylight irradiation didnotinfluence thelethal effect." 568 1020 W2809285525.pdf 12 11 separator 0.9009871 ¶ 1020 1022 W2809285525.pdf 12 12 text 0.98542035 "Weshowed that themost toxic wavelength differed atdifferent developmental stages. Morphological changes corresponding tometamorphosis might cause these differences inthe responsiveness tolight bythedifferent developmental stages." 1022 1256 W2809285525.pdf 12 13 separator 0.8912523 ¶ 1256 1258 W2809285525.pdf 12 14 text 0.99935097 "Shorter wavelengths were more harmful toeggs (Fig 1).Eggs were assumed tobedamaged bylight with ashorter wavelength because thiswavelength contains more energy. However, lower mortality wasdetected at439nmcompared to417and 454nm. Certain structures might block thetransmission of439nmlight into theD.enamgotms-nr body. Although the detailed mechanism remains unclear, embryo development might beinhibited bytheenergy ofblue light." 1258 1699 W2809285525.pdf 12 15 separator 0.99501735 ¶ 1699 1701 W2809285525.pdf 12 16 caption 0.99634993 "Fig7.Dose-respo nserelationshi pbetween light waveleng thand H2O2generatio n.RLU indicates theamount of luminesce nce. DD: 24hdark conditions." 1701 1846 W2809285525.pdf 12 17 separator 0.9390386 ¶ 1846 1848 W2809285525.pdf 12 18 paratext 0.7883467 https://d oi.org/10.1371/j ournal.pon e.0199266.g0 07 1848 1902 W2809285525.pdf 12 19 separator 0.9895175 ¶ 1902 1904 W2809285525.pdf 12 20 title 0.98526174 Toxic blue light andinsect growth stage 1904 1944 W2809285525.pdf 12 21 separator 0.8994554 ¶ 1944 1946 W2809285525.pdf 12 22 paratext 0.9836467 PLOS ONE |https://doi.or g/10.137 1/journal.po ne.01992 66 June 19,2018 13/19 1946 2024 W2809285525.pdf 12 0 paratext 0.9841609 "DINAMISIA - Jurnal Pengabdian Kepada Masyarakat Vol. 3, No. 2 Desember 201 9, Hal. 235-243 ¶ P-ISSN 2614 -7424 | E-ISSN 2614 -8927 8" 0 141 W2996459752.pdf 7 1 separator 0.99210083 ¶ 143 145 W2996459752.pdf 7 2 text 0.99348754 "Ini merupakan bentuk partisipasi masyarakat dalam mewu judkan Bumdes di Kendalase m karena salah satu penentu kemajuan Bumdes adalah partisipasi masyarakat (Tama, D. O . E., & Yanuardi, 2013) . Dengan kata lain, pengelolaan Bumdes yang melibatkan masyarakat secara langsung diharapkan mampu mendukung perekonomia ber basis pemberdayaan masyarakat (Budiono , 2015) ." 145 526 W2996459752.pdf 7 3 separator 0.98802036 "¶ ¶" 528 538 W2996459752.pdf 7 4 title 0.9854783 4. KESIMPULAN 538 552 W2996459752.pdf 7 5 separator 0.99128056 ¶ ¶ 554 560 W2996459752.pdf 7 6 text 0.9807659 "1. Kegiatan pertama PKM adalah sosialisasi dan edukasi tentang Filosofi BUMDEs dan tahapan pembentukan BUMDes. 2. Tim TPP terbentuk dengan komposisi ketua, sekretaris, bendahara, dan anggota. 3. Hasil pengisian kuisioner pada mitra menunju kkan bahwa pembentukan B UMDEs merupakan hal yang penting untuk kesejahteraan desa dan peningkatan perekonomian desa." 560 935 W2996459752.pdf 7 7 separator 0.90974826 ¶ 937 939 W2996459752.pdf 7 8 text 0.9376963 "4. Pendampingan dan FGD dalam rangka pembentukan Bumdes melalui Musyawarah Desa dengan tahapan : 1) Pendampingan tentang penentuan nama Bumde s dan pemetaan desa; 2) Sosialisasi tentang tahapan Musdes;3) pendampingan pembahasan Perdes; dan 4) Pendampingan dalam Musyawarah Desa. " 939 1231 W2996459752.pdf 7 9 separator 0.61079603 ¶ 1231 1232 W2996459752.pdf 7 10 text 0.9623938 "5. Luaran pada program ini adalah: a) terciptanya nama bumdes yaitu Bumdes Kendalasem Jaya ; b) tersusunnya perdes dan d raf AD/ART; dan c) terbe ntuknya pengurus bumdes dan unit usaha." 1232 1424 W2996459752.pdf 7 11 separator 0.97848445 ¶ ¶ 1426 1432 W2996459752.pdf 7 12 title 0.98106956 5. SARAN 1432 1441 W2996459752.pdf 7 13 separator 0.9896521 ¶ ¶ 1443 1449 W2996459752.pdf 7 14 text 0.9784762 "1. Perlu adanya pendampingan yang intensif mulai dari tahapan pertama sampai tahapan ke delapan dalam proses pembentukan BUMDes. 2. Perlu Pendampingan intensif dalam penyusunan AD/ART" 1449 1640 W2996459752.pdf 7 15 separator 0.9935218 ¶ ¶ 1642 1648 W2996459752.pdf 7 16 title 0.98973113 UCAPAN TERIMA KASIH 1648 1668 W2996459752.pdf 7 17 separator 0.98991257 ¶ ¶ 1670 1676 W2996459752.pdf 7 18 text 0.99722093 "Ucapa n terimaksih kami sampaikan kepada UNISNU Jepara melalui LPPM UNISNU atas hibah pengabdian reguler sehingga kegiatan ini dapat terlaksana dengan baik. Tak lupa kami juga mengucapkan terimaksih kepada Sekolah Bumdes Jepara atas su pport dan bimbingannya sehi ngga pengabdian kepada mitra Bumdes dapat berjalan sesuai harapan." 1676 2016 W2996459752.pdf 7 19 separator 0.98955584 "¶ ¶" 2018 2028 W2996459752.pdf 7 20 title 0.9801769 DAFTAR PUSTAKA 2028 2043 W2996459752.pdf 7 21 separator 0.9893673 "¶ ¶" 2045 2055 W2996459752.pdf 7 22 bibliography 0.9973752 "[1] Agusliansyah, K. (2016). PERAN KEPALA DESA DALAM PENGELOLAAN BADAN USAHA MILIK DESA ( BUMDes ) DI DESA JEMPARING . 4(4), 17 85–1796." 2055 2196 W2996459752.pdf 7 23 separator 0.96005297 ¶ 2198 2200 W2996459752.pdf 7 24 bibliography 0.9973223 "[2] Budiono, P. (2015). Implementasi Kebijakan Badan Usaha Milik Desa ( Bumdes ) Di Bojonegoro ( Studi di Desa Ngringinrejo Kecamatan Kalitidu Dan Desa Kedungprimpen Kecamatan Kanor ) . 4(1), 116–125." 2200 2408 W2996459752.pdf 7 25 separator 0.96360695 ¶ 2409 2411 W2996459752.pdf 7 26 bibliography 0.9969779 "[3] Fitrianto, H. (2016). Revitalisasi Kelembagaan Bumd es Dalam Upaya Meningkatkan Kemandirian dan Ketahanan Desa di Jawa Timur Institutional Revitalization of Bumdes In Efforts to Increase Independence and Village Resilience in East Java . 8(2), 915–926." 2411 2675 W2996459752.pdf 7 27 separator 0.97168744 ¶ 2676 2678 W2996459752.pdf 7 28 bibliography 0.9976844 "[4] Ihsan, A. N., & Diponegoro, U . (n.d.). Analisis Pengelol aan Badan Usaha Milik Desa ( BUMDes ) Gerbang Lentera Sebagai Penggerak Desa Wisata Lerep ." 2678 2836 W2996459752.pdf 7 29 separator 0.89568067 ¶ 2837 2839 W2996459752.pdf 7 30 bibliography 0.9979574 "[5] Karya, D., Sejati, M., & Kusuma, T. (2018). Pembentukan Dan Pengelolaan Bumdes (Badan Usaha Milik Desa) Karya Mandiri Sejati . Universitas Lampung." 2839 2995 W2996459752.pdf 7 31 separator 0.82588375 ¶ 2997 2999 W2996459752.pdf 7 32 bibliography 0.99697495 "[6] PKDSP. (2007). Pendirian dan Pengelolaan BUMDes . Malang: Fakultas Ekonomi Universitas Brawijaya." 2999 3105 W2996459752.pdf 7 0 text 0.99954605 "Five of the seven studies evaluated the biomechanical properties of excised VFs, and most of these studies reported improvement in the MSC-treated group. However, not all of the studies reached statistical significance. Whether this difference in statistical significance was related tothe low power used to detect a difference or methodological differences cannot be evaluated." 0 382 W2520103202.pdf 9 1 separator 0.95781577 ¶ 382 384 W2520103202.pdf 9 2 text 0.99949116 "Three of the studies examined mucosal wave patterns after an intervention with MSCs, and most of these studies reported an apparent improvement. However, only one study reported the statistics (P <0.01) for the comparison between the MSC- and saline-treated control groups. The significance of the comparisons in the two remaining studies was not reported." 384 747 W2520103202.pdf 9 3 separator 0.9843539 ¶ 747 749 W2520103202.pdf 9 4 text 0.99960846 "Taken together, the above-mentioned findings are encouraging for further studies. There are some fundamental limitations in the animal studies that will make it difficult to evaluate whetherhuman trials with MSCs will lead to clinically relevant improvements in phonation following an MSC treatment. First, six of the seven studies evaluated the reduction of scar tissue formation in the acute phase of healing. It is unlikely that this timeframe represents a relevant model of thetreatment of human VF scarring. A relevant model would require the administration of MSCs during a planned insult to the VFs, which may be relevant in some, but not all clinical scenarios." 749 1427 W2520103202.pdf 9 5 separator 0.9445969 ¶ 1427 1429 W2520103202.pdf 9 6 text 0.9997107 "It is unlikely that MSC treatment would be given before an observation period to assess anyspontaneous improvement in phonation before offering any treatment because of the relativecomplexity of the current autologous MSC treatments. Only one study investigating the effect of MSC treatment of chronic scar tissue formation has been published, and this study reported encouraging improvements in biomechanical properties following MSC treatment. Studies com-paring time perspectives of the injection of stem cells in relation to the specific trauma should be performed to obtain a treatment regimen focused on the exact cause of the VF lesion." 1429 2079 W2520103202.pdf 9 7 separator 0.9836967 ¶ 2079 2081 W2520103202.pdf 9 8 text 0.9995808 "We identified one other review of vocal fold regeneration. This review primarily focused on histological changes following MSC treatment with various types of scaffolds and growth fac- tors.[ 3] The correlation between histological changes and phonation is not straightforward." 2081 2363 W2520103202.pdf 9 9 separator 0.86190075 ¶ 2363 2365 W2520103202.pdf 9 10 text 0.9997287 "Therefore, we only focused on functional outcome measures, which exhibits a proven correla-tion with phonation, such as measures of a dysfunction, e.g., hoarseness and an easily fatiguedvoice. The mechanism of action is largely unknown, and further research on the exact effect of stem cell injection could clarify the results from the animal studies, such as histological changes and the persistence of the stem cells." 2365 2789 W2520103202.pdf 9 11 separator 0.9756555 ¶ 2789 2791 W2520103202.pdf 9 12 text 0.9996846 "The results of the two uncompleted clinical trials, one using expanded MSCs and the other using the heterogeneic SVF cell population, should provide useful results in the field, especially for assessments of safety concerns and feasibility. However, the limited number of clinical stud-ies indicates that much more research is necessary to provide evidence of MSC therapy for the treatment of scarred vocal folds. The authors are currently designing a prospective, blinded clinical trial of the injection of mesenchymal-derived stem cells perioperatively in Reinke ’s edema patients." 2791 3385 W2520103202.pdf 9 13 separator 0.9815786 ¶ 3385 3387 W2520103202.pdf 9 14 text 0.9997359 "In conclusion, animal studies of MSC treatment of scarred vocal folds reveal encouraging results for biomechanical and mucosal wave measurements. These results should be viewedcautiously with the limitations in the included studies, such as statistical insignificance, greatintervention variance and the existence of potential biases. Whether these results will translate to improved phonation in human trials with MSC treatment for vocal fold scarring is currently not known. The results from the two on-going clinical trials with MSCs for VF dysfunctionshould answer some of these questions and are awaited with great interest." 3387 4023 W2520103202.pdf 9 15 separator 0.9933582 ¶ 4023 4025 W2520103202.pdf 9 16 title 0.87200195 Supporting Information 4025 4048 W2520103202.pdf 9 17 separator 0.80626833 ¶ 4048 4050 W2520103202.pdf 9 18 paratext 0.92159647 S1 Appendix. Search strategy appendix.(DOCX) 4050 4095 W2520103202.pdf 9 19 separator 0.841484 ¶ 4095 4097 W2520103202.pdf 9 20 title 0.7951841 Stem Cell Therapy for Vocal Fold Scarring 4097 4139 W2520103202.pdf 9 21 paratext 0.9521628 ¶ PLOS ONE | DOI:10.1371/journal.pone.0162349 September 15, 2016 10 / 12 4139 4212 W2520103202.pdf 9 0 paratext 0.9835711 de Melo-Minardi et al. OnlineBioinfo 0 36 W4280516956.pdf 2 1 separator 0.94834787 ¶ 36 38 W4280516956.pdf 2 2 text 0.9806324 "•Module 2 - Programming : Python language, Python in bioinformatics, essential Python syntax variables, varia ble types (sets, tuples, lists, dictionaries), arithmetic operat ors, string comparators, logical operators, conditional structu res, defined repetition structures and undefined, loop control, input, and output, formatted printing, code modularization (subroutines and modules), and regular expressions. It is a practical module with several practical exercises to handon." 38 535 W4280516956.pdf 2 3 separator 0.84652925 ¶ 535 537 W4280516956.pdf 2 4 text 0.9883965 "•Module 3 - Algorithm complexity analysis : algorithm complexity functions, best case analyses, average and worst case analyses, optimal algorithms, asymptotic behavior of complexity functions, asymptotic domination, O notation, complexity classes, several examples involving, among other s, search algorithms. This module is largely made up of theoretical content, exercises are provided at the end of eac h class to fix the content learned. Submitting these activitie s is optional." 537 1037 W4280516956.pdf 2 5 separator 0.77012444 ¶ 1037 1039 W4280516956.pdf 2 6 text 0.9958817 "•Module4-Algorithmsforbioinformatics :paradigmconcept in computing, dynamic programming, token game example, tourist problem in Manhattan, distance metrics between sequences (Hamming and Levenshtein), maximum common subsequenceproblem,Needleman-Wunschalgorithm,Smith- Waterman algorithm, scoring schemes, and substitution matrices,peer-to-peeralignments,multiplealignments,glo bal alignments,localalignments,andheuristics.Thismodulea lso hassomeoptionalchallenges." 1039 1520 W4280516956.pdf 2 7 separator 0.7152574 ¶ 1520 1522 W4280516956.pdf 2 8 text 0.99422604 "•Bonusmodule :structuralbioinformaticsbonusmodule.Ithas noexercisesorpracticalactivitiesandisentirelyoptional." 1522 1635 W4280516956.pdf 2 9 separator 0.7039671 ¶ 1635 1637 W4280516956.pdf 2 10 text 0.99920833 "hetargetaudiencecomprisesundergraduateorgraduatestud ents in biological sciences and related fields with little or no programmingknowledge.Wefrequentlyreceiveaswellstuden ts who graduated in computer science-related areas. They aim to learn Python, be introduced to bioinformatics problems, andreviewsomecomputationalfundamentals.Studentsholdi ng more advanced knowledge of Python programming will benefit from the second half of the course, in which we cover more advanced topics related to algorithm complexity and classical algorithms in bioinformatics. This course can help prepare them to enter the graduate course in bioinformatics and computational biology, contributing to their acquisition o f solid computingskills." 1637 2385 W4280516956.pdf 2 11 separator 0.9855933 ¶ 2385 2387 W4280516956.pdf 2 12 text 0.9645288 Thecourseresourcesconsistofthefollowing: 2387 2428 W4280516956.pdf 2 13 separator 0.8420633 ¶ 2428 2430 W4280516956.pdf 2 14 table 0.7919021 "1.4 digital books : in pdf format, containing theory and challenges (mostly solved) for practical exercises in logic al reasoningandprogramming,totaling100pages. 2.Videorecordedclasses :35classes(" 2430 2633 W4280516956.pdf 2 15 text 0.54680836 approximately 2633 2646 W4280516956.pdf 2 16 table 0.72787327 "7h). 3.Slides: presentations used in classes will be made available in pdfformat. 4.Reviewandprogrammingtasks :quizzesforreviewoftaught conceptsandlistsofprogrammingexercises. 5.Google Colab Notebooks :" 2646 2858 W4280516956.pdf 2 17 text 0.47974774 2858 2859 W4280516956.pdf 2 18 table 0.53449434 solved and 2859 2869 W4280516956.pdf 2 19 text 0.51921755 commented 2869 2879 W4280516956.pdf 2 20 table 0.61253405 ¶ 2879 2882 W4280516956.pdf 2 21 text 0.58782005 programmingexercises. 2882 2903 W4280516956.pdf 2 22 table 0.4688966 ¶ 6. 2903 2908 W4280516956.pdf 2 23 text 0.59485626 Live classes : meetings to clarify doub 2908 2947 W4280516956.pdf 2 24 table 0.6093617 "ts through video conference" 2947 2976 W4280516956.pdf 2 25 text 0.50500864 s 2976 2977 W4280516956.pdf 2 26 table 0.5406064 with 2977 2981 W4280516956.pdf 2 27 text 0.7554858 "thestudents.Thecourse lastsfor up to90days andtakesabout 40 h toattend classes, read the material, solve course exercises, and compl ete thecourse." 2981 3132 W4280516956.pdf 2 28 separator 0.99674463 ¶ 3132 3134 W4280516956.pdf 2 29 title 0.99092096 3.1. Student Evaluation 3134 3158 W4280516956.pdf 2 30 separator 0.9963251 ¶ 3158 3160 W4280516956.pdf 2 31 text 0.9994983 "Student assessment considers attending asynchronous class es, reading materials, review exercises, and practical programmi ng exercises.Tobeconsideredacompletestudent,thestudentm ust attend 75% of classes, attend final classes, and complete 60% of the submitted exercises. We collect the data describing t he use of the resources by the students from the Moodle platform." 3160 3541 W4280516956.pdf 2 32 separator 0.78699833 ¶ 3541 3543 W4280516956.pdf 2 33 text 0.99951935 "The data set consists of yes/no values for each pair of student - resource. Review exercises contain closed questions of vario us types: multiple-choice, association, and filling in gaps, amon g others. The programming exercises are practical and have to be solved using the Python programming language. Proposed solutions in a Google Colab Notebook4and a video explaining the solution step-by-step accompanies each list of programmin g exercises. Thecorrectionoftheexercisesisdonebythestud ents themselves through correction classes and workbooks of solv ed activities. The analysis was carried out with data from 245 students from different courses, most of them coming from the biological sciences course, about 39.1% (see Figure1). The data used consists of a table formed by the course resources such a s class and delivery of activities with values of yes for attend ed and delivered and no for unattended and not delivered and the course completion section with values of yes and no. Data were obtained from the Moodle platform. To obtain the reports used intheanalysis,thefunction“coursemanagement”andthen“v iew participation report” was used. We chose “all course activities ,” throughout the course period, filtered only by students and th e “view”action.Then,wedownloadaspreadsheetinxlsformata nd performalltheanalysisusingOrangeDataMining." 3543 4934 W4280516956.pdf 2 34 separator 0.9963379 ¶ 4934 4936 W4280516956.pdf 2 35 title 0.9920404 4. MATERIALS AND METHODS 4936 4961 W4280516956.pdf 2 36 separator 0.9966443 ¶ 4961 4963 W4280516956.pdf 2 37 text 0.99959654 "To obtain the reports used in the analysis, we used the Moodle function “course management” and then “view participation report.” We chose “all course activities,” throughout the co urse period, filtered only by students and by the “see” action. Each lineofthedatasetisastudent,eachcolumnisacourseresou rce, and the domain of the features is in Yes,Nodomain. We then downloaded an xls format sheet and performed all the analysis usingOrangeDataMining5software." 4963 5437 W4280516956.pdf 2 38 separator 0.99701 ¶ 5437 5439 W4280516956.pdf 2 39 title 0.99188 "4.1. Visualizing Students According to Their Profiles of Material Accession" 5439 5516 W4280516956.pdf 2 40 separator 0.99455345 ¶ 5516 5518 W4280516956.pdf 2 41 text 0.99957323 "First of all, we needed to have a visual grasp of the whole set of students according to completion or abandonment of the course. We used Multidimensional scaling (MDS) Carroll and Arabie(1998) which is a technique that finds (in this case) a 2D projection of instances, reproducing their distances as well as possible. As input, the technique needs a matrix of distances." 5518 5900 W4280516956.pdf 2 42 separator 0.9719997 ¶ 5900 5902 W4280516956.pdf 2 43 bibliography 0.7268217 "4https://colab.research.google.com/ 5https://orangedatamining.com/" 5902 5971 W4280516956.pdf 2 44 separator 0.65873444 ¶ 5971 5973 W4280516956.pdf 2 45 paratext 0.9854024 Frontiers in Education | www.frontiersin.org 3 May 2022 | Volume 7 | Article 727019 5973 6057 W4280516956.pdf 2 0 paratext 0.9869483 Mar. Drugs 2022 ,20, 440 13 of 25 0 33 W4283747811.pdf 12 1 separator 0.9057771 ¶ 33 35 W4283747811.pdf 12 2 text 0.7944123 "strain, selecting cells with higher environmental tolerance, and thus, displaying more robust," 35 132 W4283747811.pdf 12 3 title 0.45608917 ta 132 135 W4283747811.pdf 12 4 text 0.48515296 ilor 135 139 W4283747811.pdf 12 5 title 0.48634273 -made 139 144 W4283747811.pdf 12 6 text 0.48943546 phenotypes [8,78 144 161 W4283747811.pdf 12 7 title 0.40716642 , 161 162 W4283747811.pdf 12 8 text 0.4062122 139 162 165 W4283747811.pdf 12 9 paratext 0.40391672 ]. 165 167 W4283747811.pdf 12 10 separator 0.9462514 ¶ 167 169 W4283747811.pdf 12 11 paratext 0.9863911 Mar. Drugs 2022 , 20, 440 13 of 25 169 205 W4283747811.pdf 12 12 separator 0.94502616 ¶ ¶ 206 212 W4283747811.pdf 12 13 text 0.99950796 "housekeeping genes and growth. If the stressfu l conditions are withdrawn, the stress-in- duced genes are repressed and the cell resumes its normal activity. The conditions of adaptive laboratory evolution keep the stress constant from one generation to the next and the stress response is kept active, so that any mutation that enables the cell to grow under stressful conditions is likely to be fa vored. Likewise, each generational cycle im- proves the original wildtype strain, selecting cells with higher environmental tolerance, and thus, displaying more robust, tailor-made phenotypes [8,78,139]." 213 835 W4283747811.pdf 12 14 separator 0.63952106 ¶ 836 838 W4283747811.pdf 12 15 text 0.83979535 . 838 840 W4283747811.pdf 12 16 separator 0.9934659 ¶ 841 843 W4283747811.pdf 12 17 caption 0.9687487 "Figure 5. Diagram of adaptive laboratory experiments and expected results. Left—adaptive labora- tory evolution experimental designs in batch and continuous mode. The abiotic stress is kept con- stant or increased, and this leads to the improvem ent of the culture. Right—after a" 843 1127 W4283747811.pdf 12 18 text 0.53433096 daptive 1127 1134 W4283747811.pdf 12 19 caption 0.7207864 "labora- tory evolution, the e" 1134 1166 W4283747811.pdf 12 20 text 0.52904046 volved 1166 1172 W4283747811.pdf 12 21 caption 0.5983604 microalgal strain will be 1172 1199 W4283747811.pdf 12 22 text 0.7458063 "able to tolerate the abiotic stress while main- taining favorable growth parameters and a balanced biochemical profile." 1199 1320 W4283747811.pdf 12 23 separator 0.9906696 ¶ 1321 1323 W4283747811.pdf 12 24 text 0.9996383 "Adaptive laboratory evolution is an effect ive strategy to isolate improved strains, since it stimulates the accumulation of beneficial mutations in several genes in parallel, acting in a genome-wide manner, which favors the permanence and stability of the in-tended alterations [8,78]. Moreover, by induci ng stress conditions, the underlying micro- algal metabolic mechanisms and responses to environmental stress might be further scru- tinized, along with information about genes imparting stress tolerance and the design of novel strains through synthetic biology (experimental evolution) [6]. It is also useful to apply tools, such as FACS, to assist in the selection of the fittest mutants, based on, for example, their cell morphology or pigment content [8]. Adaptive laboratory evolution also allows the study of evolutionary trade-offs, since adaptations that provide better fitness in one environment might lead to maladaptation in another." 1323 2299 W4283747811.pdf 12 25 separator 0.9507443 ¶ 2300 2302 W4283747811.pdf 12 26 text 0.99971205 "However, cells grown in the laboratory mi ght be under evolutionary constraints im- posed by lower genetic variation due to the sm aller population size as compared to the genetic diversity found in larger microalgal populations present in nature; this can ham- per or delay the isolation of mutants with th e desired phenotype [51] . As a result, a sig- nificant and uncertain number of generations is usually necessary to complete the evolu- tionary process, which can take from months to years [8,51,78]. This lag in microalgae adaption is also related to their larger geno mes and lower growth rates compared to those" 2302 2938 W4283747811.pdf 12 27 separator 0.98280495 ¶ 2939 2941 W4283747811.pdf 12 28 caption 0.9362009 "Figure 5. Diagram of adaptive laboratory experiments and expected results. Left—adaptive labora- tory evolution experimental designs in batch and continuous mode. The abiotic stress is kept constant or increased, and this leads to the improvement of the culture. Right—after adaptive laboratory evolution, the evolved microalgal strain will be able to tolerate the abiotic stress while maintaining favorable growth parameters and a balanced biochemical profile." 2941 3410 W4283747811.pdf 12 29 separator 0.99318826 ¶ 3410 3412 W4283747811.pdf 12 30 text 0.99967057 "Adaptive laboratory evolution is an effective strategy to isolate improved strains, since it stimulates the accumulation of beneficial mutations in several genes in parallel, acting in a genome-wide manner, which favors the permanence and stability of the intended alterations [ 8,78]. Moreover, by inducing stress conditions, the underlying microalgal metabolic mechanisms and responses to environmental stress might be further scrutinized, along with information about genes imparting stress tolerance and the design of novel strains through synthetic biology (experimental evolution) [ 6]. It is also useful to apply tools, such as FACS, to assist in the selection of the fittest mutants, based on, for exam- ple, their cell morphology or pigment content [ 8]. Adaptive laboratory evolution also allows the study of evolutionary trade-offs, since adaptations that provide better fitness in one environment might lead to maladaptation in another." 3412 4378 W4283747811.pdf 12 31 separator 0.9597104 ¶ 4378 4380 W4283747811.pdf 12 32 text 0.99970686 "However, cells grown in the laboratory might be under evolutionary constraints imposed by lower genetic variation due to the smaller population size as compared to the genetic diversity found in larger microalgal populations present in nature; this can hamper or delay the isolation of mutants with the desired phenotype [ 51]. As a result, a significant and uncertain number of generations is usually necessary to complete the evolutionary process, which can take from months to years [ 8,51,78]. This lag in microalgae adaption is also related to their larger genomes and lower growth rates compared to those of bacteria and yeast, and thus, the efficiency of this approach depends on the initial strain chosen for improvement and the stress factors applied [ 8]. In addition, creating laboratory mutant strains might result in organisms that are unable to thrive on more variable, less predictable environments, such as those of outdoor industrial reactors, since it is hard to mimic such conditions in a laboratorial context [8]." 4380 5434 W4283747811.pdf 12 0 paratext 0.98728466 1672 Scientometrics (2019) 119:1669–1694 0 40 W2921197276.pdf 3 1 separator 0.6081119 40 41 W2921197276.pdf 3 2 paratext 0.8377703 ¶ 1 3 41 46 W2921197276.pdf 3 3 separator 0.9948613 ¶ 46 48 W2921197276.pdf 3 4 text 0.99792016 "Figure 1 and Table 1 clarify the correspondence between the approaches. (We will show the differences empirically in a later section.) In Fig. 1 the left axis is logarithmic—that is, log(1) to log(100) —whereas the right axis is linear (one to six). In the original scheme of Bornmann and Mutz (2011), the relative weighting of a top-1% and top-10% paper was only 6:4.5 (equivalent to 4:3) whereas we apply 10:1 (= 10) in the new scheme. Using quantiles (Leydesdorff and Bornmann 2011), the relation between a top-1% and top-10% paper would only be 99:89 (= 1.1)." 48 627 W2921197276.pdf 3 5 separator 0.96088123 ¶ 628 630 W2921197276.pdf 3 6 text 0.9698012 "In other words, we distinguish between I3 as a general scheme and a possible family of specific weighting schemes. The latter are applications for specific evaluation contexts. In general, I3 can be written as follows: where PR defines the lower threshold of the respective percentile rank class and W the corresponding weight; n is the number of classes and weights, respectively. In this nota- tion, the scheme proposed by Bornmann and Mutz (2011)—at the time called PR6—can be written as follows: I3(99-6, 95-5, 90-4, 75-3, 50-2, 0-1); and the scheme in this paper (I3*) I3/parenleft.s1PR1−W1," 630 1240 W2921197276.pdf 3 7 math 0.5469553 PR 1240 1242 W2921197276.pdf 3 8 text 0.5140371 2− 1242 1244 W2921197276.pdf 3 9 math 0.5023466 W2 1244 1246 W2921197276.pdf 3 10 text 0.5566614 , 1246 1247 W2921197276.pdf 3 11 math 0.56743866 ...PRn−Wn/parenright.s1 1247 1268 W2921197276.pdf 3 12 separator 0.99596345 ¶ 1268 1270 W2921197276.pdf 3 13 caption 0.9850154 Fig. 1 Weighting factors of the percentile ranks in Bornmann and Mutz (2011) and this study 1270 1363 W2921197276.pdf 3 14 separator 0.99333644 ¶ 1363 1365 W2921197276.pdf 3 15 table 0.5772067 Table 1 Weight 1365 1381 W2921197276.pdf 3 16 title 0.50159913 ing 1381 1384 W2921197276.pdf 3 17 table 0.92874515 "factors of the percentile ranks in Bornmann and Mutz (2011) and this studyPercentile ranks Bornmann and Mutz (2011)This study 99–100 6 100 95–98 5 10 90–94 4 10 75–89 3 2 50–74 2 2 0–49 1 1" 1384 1592 W2921197276.pdf 3 0 paratext 0.98475724 Springer Nature 2021 L ATEX template 0 36 W4297830961.pdf 9 1 separator 0.99224764 ¶ 36 38 W4297830961.pdf 9 2 title 0.93124294 Article Title 9 38 54 W4297830961.pdf 9 3 separator 0.99124175 ¶ 54 56 W4297830961.pdf 9 4 bibliography 0.997824 "[15] Y. Hayashi, Y. Xiao, N. Sakamoto, H. Miyahara, G. Niimi, M. Watanabe, A. Okino, K. Horioka, and E. Hotta: Jpn. J. Appl. Phys. 42, 5285 (2003)" 56 205 W4297830961.pdf 9 5 separator 0.8995855 ¶ 205 207 W4297830961.pdf 9 6 bibliography 0.99774134 "[16] M. Shuker, A. Ben-kish, R.A. Nemirovsky, A. Fisher, and A. Ron: Phy s. Plasmas 13, 013102 (2006)" 207 311 W4297830961.pdf 9 7 separator 0.9618521 ¶ 311 313 W4297830961.pdf 9 8 bibliography 0.997943 "[17] Y.L. Cheng, B.H. Luan, Y.C. Wu, Y.P. Zhao, Q. Wang, W. Zheng, H. Peng, and D. Yang: Acta Phys. Sin. 54, 4979 (2005)" 313 436 W4297830961.pdf 9 9 separator 0.84836227 ¶ 436 438 W4297830961.pdf 9 10 bibliography 0.9977405 "[18] J.D. Huba: NRL plasma formulary (Naval Research Laboratory, Wash- ington, 1998), pp. 28-29" 438 536 W4297830961.pdf 9 11 separator 0.8929406 ¶ 536 538 W4297830961.pdf 9 12 bibliography 0.99702036 "[19] Y.B. Zel’Dovich, Y.P. Raizer: Physics of shock waves and high- temperature hydrodynamic phenomena (Academic Press, New York, 1967), pp. 29-44" 538 689 W4297830961.pdf 9 0 paratext 0.97227836 18ISSN 1648-2824 KALBŲ STUDIJOS. 2012. 20 NR. * STUDIES ABOUT LANGUAGES. 2012. NO. 20 0 86 W2017302706.pdf 0 1 separator 0.8962953 ¶ 87 89 W2017302706.pdf 0 2 title 0.984909 The Use of Software for the Analysis of Lexical Properties of Legal Discourse 89 167 W2017302706.pdf 0 3 separator 0.7841296 ¶ 168 170 W2017302706.pdf 0 4 paratext 0.8969708 "Daiva Macko http://dx.doi.org/10.5755/j01.sal.0.20.1190" 170 230 W2017302706.pdf 0 5 separator 0.9935452 ¶ 231 233 W2017302706.pdf 0 6 text 0.999186 "Abstract. The use of computational tools in linguistic research is at the core of corpus linguistics. Currently, specialised lexical software contains elaborate statistical measures that enable a detailed quantitative analysis of corpus data. This paper analyses typical collocations frequently used in the appellate judgments of the European Court of Justice (ECJ). Right verbal collocates of Court are analysed in terms of frequency, statistical significance and characteristic semantic patterns. The WordSmith Tools program , Version 5.0 was used to measure the frequency and significance of the collocations; specialised computational tools were also used to compare the use of seleceted collocations with the use of corresponding collocations in the British National Corpus, which was used as the source of general English. The research results show that typical collocations used in the appellate judgments of the ECJ differ from the general English language in terms of frequency and statistical significance and exhibit unique semantic characteristics, therefore suggesting that there are considerable lexical differences between legal and general English that should be taken into account in teaching and learning." 233 1482 W2017302706.pdf 0 7 separator 0.95780694 ¶ 1484 1486 W2017302706.pdf 0 8 text 0.9465055 Keywords: collocation, corpus, frequency, negative stance, statistical significance. 1486 1571 W2017302706.pdf 0 9 separator 0.9952915 ¶ ¶ 1573 1579 W2017302706.pdf 0 10 title 0.9890506 Aim 1579 1583 W2017302706.pdf 0 11 separator 0.99400234 ¶ 1584 1586 W2017302706.pdf 0 12 text 0.99955267 "The present research aims to illustrate the use of lexical software for the analysis of le xical properties of legal discourse. It is supposed here that the most frequent uses are more likely to be characteristic of the language variety analysed and therefore information on the frequency and statistical significance of lexical items in the specific genre is of great value in characterising the specificity of the discourse. The differences in the use of selected collocations between the general and specialised English also imply that specific collocational co mpetence should be involved in teaching and learning specialised English in general and legal English in particular." 1586 2295 W2017302706.pdf 0 13 separator 0.99611586 ¶ 2297 2299 W2017302706.pdf 0 14 title 0.9898939 Previous Research 2299 2317 W2017302706.pdf 0 15 separator 0.9941114 ¶ 2318 2320 W2017302706.pdf 0 16 text 0.99952626 "The use of software for linguis tic research is of great value. Firstly, it provides a linguist with a novel type of data. For instance, wordlists and concordances are products generated from the corpora by the use of specialised software. These products are available due to computer technologies exclusively and are therefore un ique. In addition, as the capacity of computers grows, it is possible to store increasingly larger amounts of data. The specialised linguistic software allows gene rating frequency lists from large corpora within a few minutes, which would otherwise be hardly feasible at all. As Biber et al. (2004, p.21–22) note, not only are such data more precise and complete, but they are also more representat ive of the language variety under investigation. In add ition, research in the field of collocational studies has shown that the use of computational tools provides data that are not accessible by intuition, suggesting that the users of language are to some extent unaware of their own collocational competence and the patterns that they pr oduce (Widdowson, 2000, p.6)." 2320 3468 W2017302706.pdf 0 17 separator 0.93684334 ¶ 3469 3471 W2017302706.pdf 0 18 text 0.9972889 "This objectivity distinguishes corpus linguistics as a valuable quantitative method. Sinclair has often emphasized the importance of objective observance of language in use in order to find evidence , or facts about language and its regularities (for example, see Sinclair, 1991, p.39). The em pirical nature of this methodological approach reli es on elaborate quantitative analysis of the corpus data. As McEnery & Wilson (2001, p.77) point out, proper and valid sampling and significance techniques provide not only a precise information on the frequency of certain linguis tic phenomena, but they also enable comparisons between different corpora." 3471 4153 W2017302706.pdf 0 19 separator 0.9740444 ¶ 4155 4157 W2017302706.pdf 0 20 text 0.9996558 "The earliest empirical research into collocation involving the use of computers was the OSTI report conducted by Sinclair et al. Since then, many modern statistical tools have been developed to analyse collocations. However, the use of statistical measures needs to be balanced with qualitative analysis (McEnery & Wilson, 2001, p.76–77). Probably the main benefit of applying computational techniques in corpus work is proving that the use of language includes recurrent prefabricated constructions (Kennedy, 1998, p.270). Yet, as Sinclair (2004) has summed up, the point is that nobody beli eves that language occurs by chance. <...> Statistics, however , only tells us that co- occurrence of two (or more) ite ms is probably not accidental." 4157 4929 W2017302706.pdf 0 21 separator 0.9834265 ¶ 4930 4932 W2017302706.pdf 0 22 text 0.99655956 "It is generally agreed that the origins of the concept of collocation in linguistics lie in Firth’s definition of the phenomenon as actual words in habitual company (Firth, 1957, p.14 quoted in Kenn edy, 1998, p.108), or “the company words keep” (Firth quoted in Hill, 2000, p.48). In the current research, a statistical approach to collocation is followed rather than a semantically-based approach. A statistically-based concept of collocation relies on the application of computational tools to large corpora and extraction of recurrent patterns of words (Siepmann, 2005, p.410–411). The statistical approach was advocated and developed by Sinclair (Crowther et al, 2002, p.58). The frequency criterion seems to be acceptable to many linguists and thus can be stated to lie at the heart of the statistically-based concept of collocation (see Bartsch," 4932 5817 W2017302706.pdf 0 23 bibliography 0.54544055 ¶ 2004 5818 5825 W2017302706.pdf 0 24 text 0.67337656 , p.59–60; Otani 5825 5841 W2017302706.pdf 0 25 bibliography 0.595593 , 2005 5841 5847 W2017302706.pdf 0 26 text 0.49821538 , 5847 5848 W2017302706.pdf 0 27 bibliography 0.58920115 p 5848 5850 W2017302706.pdf 0 28 text 0.6378283 .5; Hanks, 2008, p.222; 5850 5873 W2017302706.pdf 0 0 paratext 0.85440314 33 0 2 W3196929119.pdf 32 1 separator 0.9920062 ¶ 3 5 W3196929119.pdf 32 2 bibliography 0.9942145 "63 Li Z, Li X, Huang Y -Y, Wu Y, Liu R, Zhou L, et al. Identify potent SARS -CoV-2 main 720 protease inhibitors via accelerated free energy perturbation- based virtual screening of 721 existing drugs. Proceedings of the National Academy of Sciences 2020; 117: 27381 -7. 722" 6 287 W3196929119.pdf 32 3 separator 0.9058888 ¶ 288 290 W3196929119.pdf 32 4 bibliography 0.9922317 "64 Zhu W, Xu M, Chen CZ, Guo H, Shen M, Hu X, et al. Identification of SARS -CoV-2 3CL 723 Protease Inhibitors by a Quantitative High- Throughput Screening. ACS Pharmacology & 724 Translational Science 2020; 3: 1008 -16. 725" 290 521 W3196929119.pdf 32 5 separator 0.94072676 ¶ 522 524 W3196929119.pdf 32 6 bibliography 0.9961373 "65 Kitamura N, Sacco MD, Ma C, Hu Y, Townsend JA, Meng X, et al. Expedited Approach 726 toward the Rational Design of Noncovalent SARS- CoV-2 Main Protease Inhibitors. J 727 Med Chem 2021." 524 720 W3196929119.pdf 32 7 separator 0.8245203 728 ¶ 721 728 W3196929119.pdf 32 8 paratext 0.8642737 729 . CC-BY 4.0 International license available under a(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. 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A.: Nutrient re- lease and uptake by littoral macrophytes during water https://doi.org/10.5194/gmd-16-4315-2023 Geosci. Model Dev., 16, 4315–4329, 2023" 6772 6965 W4385369881.pdf 12 0 paratext 0.97416943 جمةل الآداب / ملحق العدد 231 (آآذار) 1212 / م 2112 هـ 0 101 W3081742536.pdf 4 1 separator 0.9936498 ¶ 102 104 W3081742536.pdf 4 2 paratext 0.5812 768 وت اااااااة غااااااا يور ااا 104 143 W3081742536.pdf 4 3 bibliography 0.5353027 اااا 143 147 W3081742536.pdf 4 4 paratext 0.5472011 ع اللت 147 153 W3081742536.pdf 4 5 bibliography 0.5067577 باااااااة 153 163 W3081742536.pdf 4 6 paratext 0.48951858 الوس 163 168 W3081742536.pdf 4 7 bibliography 0.48817295 لآاااااااة 168 179 W3081742536.pdf 4 8 paratext 0.5050057 . 179 180 W3081742536.pdf 4 9 bibliography 0.4613767 ( 180 181 W3081742536.pdf 4 10 paratext 0.48885345 فوكددد 181 188 W3081742536.pdf 4 11 bibliography 0.5240183 دد 188 190 W3081742536.pdf 4 12 paratext 0.51047677 ددا 190 193 W3081742536.pdf 4 13 bibliography 0.63745445 , صددددددد 193 203 W3081742536.pdf 4 14 paratext 0.48954168 وفي 203 206 W3081742536.pdf 4 15 bibliography 0.57801175 ا و ريبيكدددددددا را 206 226 W3081742536.pdf 4 16 paratext 0.46576115 يد 226 228 W3081742536.pdf 4 17 bibliography 0.6849343 دددددد 228 234 W3081742536.pdf 4 18 paratext 0.5107033 ت 234 235 W3081742536.pdf 4 19 bibliography 0.49060994 , 235 236 W3081742536.pdf 4 20 paratext 0.6059138 2002 236 241 W3081742536.pdf 4 21 bibliography 0.4859594 , 241 243 W3081742536.pdf 4 22 paratext 0.4214763 ¶ 243 245 W3081742536.pdf 4 23 bibliography 0.87309647 ص20. ) (Foca, Sofia and Rebecca Wright, 2005, p. 80) 245 299 W3081742536.pdf 4 24 separator 0.99578536 ¶ 300 302 W3081742536.pdf 4 25 text 0.9251602 ب يااااااا ا حتسسااااااا الن ااااااا آة تت ااااااا خ تن ااااااا تااااااا ال آااااااا ال تحاااااااخر ا ويةآاااااااة 304 430 W3081742536.pdf 4 26 separator 0.6938392 ¶ 432 434 W3081742536.pdf 4 27 text 0.94467807 و و اااااا ااااااه الت اااااا ي ب اااااا ااااااع ح اااااا ق ع ال آ ااااااآة ا ست آااااااةا حتاااااا تاااااا س ال اااااا لا 435 568 W3081742536.pdf 4 28 separator 0.6251069 ¶ 570 572 W3081742536.pdf 4 29 text 0.4468527 جت 572 575 W3081742536.pdf 4 30 table 0.52864176 حاااااا سخيااااااخ ق ختااااااا س ااااااة ال آ ااااااة تاااااا 4 اااااا و8464 تاااااا تااااااا اور ن اااااا آة 575 697 W3081742536.pdf 4 31 text 0.41874707 تاااااا 697 706 W3081742536.pdf 4 32 separator 0.452062 ¶ 706 707 W3081742536.pdf 4 33 text 0.91513693 باااااا وي حاااااا شاااااا و ت ت اااااا الن اااااا آة اااااا ي ب لحوةااااااة اااااا ب ااااااخ الن اااااا آة ااااااااا 707 843 W3081742536.pdf 4 34 separator 0.6214925 ¶ 844 846 W3081742536.pdf 4 35 text 0.8965418 التأااااااا و سااااااا ت جاااااااو ت ةآااااااا الوأ بااااااا ا ج آاااااااة اااااااا تأااااااا و آ توشاااااااخ ب اااااااتواتيسآ 846 982 W3081742536.pdf 4 36 separator 0.9527934 ¶ 985 987 W3081742536.pdf 4 37 text 0.94149226 التح ي آاااااااة ا اااااااآة ل ةاااااااو ال اااااااو التح ياااااااة الن ااااااا ااااااا ب اااااااخ الجني آاااااااة ااااااا ب اااااااخ 987 1138 W3081742536.pdf 4 38 separator 0.7942504 ¶ 1140 1142 W3081742536.pdf 4 39 text 0.9673617 "الحخاباااااة ااااا ب اااااخ الل ل نآ لآاااااة ا ت ااااا حااااايع ة نااااا الحوةاااااة الن ااااا آة تأ لاااااي ب ل ااااا ار جااااايع الوساااااة ال اااااوور تااااا الح ااااا ال اسبااااا ح لااااا الحوةاااااة السخياااااخر وجاااااوا ا وت تااااا جين ااااا الااااا وع ال آاااااة تتلااااا ع ح اااااي ا وت تااااا لاااااآ أ ااااا ال اااااو ا وت تااااا جيع الوسة ال وور . يااااااوق الب حااااااأ وع ل حوةااااااة الن خآااااااة ال ااااااخور اااااا ج اااااا ور أآاااااا ال ااااااو الن اااااا" 1142 1686 W3081742536.pdf 4 40 separator 0.54443914 ¶ 1689 1691 W3081742536.pdf 4 41 text 0.64318806 س آ اااااااا اااااااا آ اااااااا تلآااااااااا ااااااااع واااااااااخا و اااااااا انأ ِ اااااااا ن اااااااا ل و ااااااااة الن خآ ااااااااة 1691 1849 W3081742536.pdf 4 42 separator 0.9808835 ¶ 1853 1855 W3081742536.pdf 4 43 bibliography 0.99264497 "(الرويلددي ميجددان والبددازعي سددعد , 2002, ص60-66) (Al-Ruwaili Megan and Al -Bazei Saad, 2002, pp. 60 -66" 1855 1966 W3081742536.pdf 4 44 separator 0.99520785 ¶ 1969 1971 W3081742536.pdf 4 45 title 0.7423812 8. تع ال ااااااااااخ ال ااااااااااوي ل ن ااااااااااخ الن اااااااااا ااااااااااا ا ااااااااااتِآ ي ا نتاااااااااا ا نباااااااااا ال اااااااااا و أ 1971 2129 W3081742536.pdf 4 46 separator 0.98873794 ¶ 2129 2131 W3081742536.pdf 4 47 text 0.7212486 ال ِاااااو الاااااا وا اااااا الوساااااة أااااا آ ا اااااع ب اااااا تااااا ع الن اااااخ الن ااااا يتحاااااو ب ااااا ة 2132 2266 W3081742536.pdf 4 48 separator 0.9756595 ¶ 2269 2271 W3081742536.pdf 4 49 text 0.55373955 ة ح و ياع: ¶ 2275 2295 W3081742536.pdf 4 50 table 0.45004553 و . ا : خِ 2295 2309 W3081742536.pdf 4 51 text 0.4552157 وا ة ور ال و 2309 2323 W3081742536.pdf 4 52 table 0.42063868 ور 2323 2325 W3081742536.pdf 4 53 text 0.44892347 ت التس وي 2325 2336 W3081742536.pdf 4 54 table 0.43295917 الا 2336 2340 W3081742536.pdf 4 55 text 0.46620834 ونت 2341 2345 W3081742536.pdf 4 56 table 0.451099 س الو 2345 2354 W3081742536.pdf 4 57 text 0.4222933 ِّس 2354 2359 W3081742536.pdf 4 58 table 0.50088704 ". ي . اآلو و : خِوا ة التس وي الت ونت ستا" 2359 2406 W3081742536.pdf 4 59 text 0.75799686 "الن ت. ي ت ِ ال ِح واع ت ال اقه نخ ن أة احخر ا ا آ ة ال وور و اات ." 2408 2492 W3081742536.pdf 4 60 separator 0.8764507 ¶ 2493 2495 W3081742536.pdf 4 61 text 0.94005394 "ل ااااخ وخو ااااة ااااااا الن ااااخ و اااا ونب آ ااااة ةبيااااور تلاااا اااا حة الن ااااخ ا خجاااا الن اااا ا التاااا تحتاااااااا ال ااااااا و أ ا خجااااااا س اااااااة لن اااااااا ِااااااا يت ي ااااااا ج ااااااا وا ااااااا ةشااااااا التااااااا ويس ا خجااااااا ل ااااااا و أ ا نبااااااا اااااااع وِااااااا ت سااااااا وِي الن ااااااا ت الوادِاااااااخا ال ااااااا بِ ت ياااااااخاع ج ااااا ِ ع ن ااااا ا ت حت ااااااق اااااع غياااااواع اتو ااااا ت ِاااااآغ ة التسوِ اااااة ا نب آ اااااة ال ت يِّااااا ر الااتآ اااااة" 2495 3066 W3081742536.pdf 4 62 separator 0.57447904 ¶ 3067 3069 W3081742536.pdf 4 63 text 0.8799536 "ا نب آ ااااااة تةااااااو ا شاااااا و ا ت آ اااااا اتخوال اااااا ل ااااااا ا ال اااااا لا الواااااا وس . تحخيااااااخ ِاااااا لغااااااة ا نبااااااااا لِ ااااااااا و ا ااااااااا ي ا نبااااااااا ال ت يِّااااااااا تااااااااا الل ااااااااا ا ال نأااااااااا الل ااااااااا ا" 3069 3378 W3081742536.pdf 4 64 separator 0.67918277 ¶ 3379 3381 W3081742536.pdf 4 65 text 0.8596182 ال ةت ي نآة الس ة ال ق ال غ آ ة ال و ال س ي ة . 3381 3442 W3081742536.pdf 4 66 separator 0.8231703 ¶ ¶ 3443 3507 W3081742536.pdf 4 0 paratext 0.9753795 "45Innovative Marketing, Volume 17, Issue 2, 2021 http://dx.doi.org/10.21511/im.17(2).2021.05Abstract" 0 102 W3159344060.pdf 1 1 separator 0.9951861 ¶ 102 104 W3159344060.pdf 1 2 text 0.99839896 "This study aims to examine the marketing channel optionsavailable for corn produc - ers in South Sulawesi, the production center in Indonesia, as well as impact of such a choice on their income level. The target group was corn producers and corn traders." 104 364 W3159344060.pdf 1 3 separator 0.7433281 ¶ 365 367 W3159344060.pdf 1 4 text 0.9865958 "The total sample comprised 150 people, consisting of 120 corn producers and 30 corn intermediary traders within South Sulawesi Province. The results showed that three marketing channels accessed by producers are zero-level, one-level, and two-level channels. The net profit margin obtained by intermediary traders per kg is different by types for each marketing channel due to different marketing activities leading to dif - ferent costs spent. The most efficient marketing channel is the zero-level channel that conducts direct selling to breeders. It followed by the one-level channel (from farmers to collectors and consumers). Finally, the two-level channel (from producers to mer - chant traders) showed the lowest efficiency. It should be mentioned that the zero-level channel offers a slight price increase for producers compared to other channels. Its consumers only buy limited number of products so that it does not have a wide impact on producer’s welfare. The study also found high input costs spent to cultivate corn due to land rent, fertilizers, and pesticides.Jusni Ambo Upe (Indonesia), Andi Aswan (Indonesia)" 367 1530 W3159344060.pdf 1 5 separator 0.9930508 ¶ 1530 1532 W3159344060.pdf 1 6 title 0.9818696 "The choice of a marketing channel to benefit corn producer’s welfare in Indonesia" 1532 1623 W3159344060.pdf 1 7 separator 0.97253996 ¶ 1623 1625 W3159344060.pdf 1 8 paratext 0.9783877 "Received on: 14th of March, 2021 Accepted on: 26th of April, 2021 Published on: 5th of May, 2021" 1625 1729 W3159344060.pdf 1 9 separator 0.99571526 ¶ 1729 1731 W3159344060.pdf 1 10 title 0.99064523 INTRODUCTION 1731 1744 W3159344060.pdf 1 11 separator 0.9957333 ¶ 1744 1746 W3159344060.pdf 1 12 text 0.996821 "The agricultural sector is one of the prominent sectors contribu ting to economic development in Indonesia as this country is supported by abundant natural resources (Mahanty et al., 2017). The leading ag - ricultural commodities, especially in South Sulawesi, are food crops , one of which is corn also known as Zea mays L that is the second most cultivated commodities after rice in the area (Suddin et al., 2020; Syaiful et al., 2020; Hatima et al., 2020; Jusni & Aswan, 2020; Taufik et al., 2015). This province, its districts at most, is said to be a c entre of corn productionfor consumption and dominant inputs for animal food supply (Hatima et al., 2020; Tetik et al., 2019). " 1746 2457 W3159344060.pdf 1 13 separator 0.5245052 ¶ 2457 2458 W3159344060.pdf 1 14 text 0.99920785 "Although the province has sufficient soil fertility for growing corn, the welfare of corn producers in this area is inadequate (Hatima et al., 2020;Yuniarsih & Taufiq, 2020; Suprapti et al., 2016). Incre ased pro - duction and demand for any type of corn product is not followed by a proportional increase in farmer’s income level (Suprapti et al., 2016)." 2458 2825 W3159344060.pdf 1 15 separator 0.73305035 ¶ 2826 2828 W3159344060.pdf 1 16 text 0.9981307 "Many empirical works noted some factors that affect the welfare of corn producers (Gede & Nyoman Djinar, 2019; Sebayang et al., 2019)." 2828 2966 W3159344060.pdf 1 17 separator 0.55383366 ¶ 2967 2969 W3159344060.pdf 1 18 text 0.9971361 "For example, the quality of corn depends on harvest and post-har - vest handling (Fil’aini et al., 2020), land area, labor, farmer producti on ©" 2969 3116 W3159344060.pdf 1 19 paratext 0.88429886 Jusni Ambo Upe, Andi Aswan, 2021 3116 3149 W3159344060.pdf 1 20 separator 0.9838835 ¶ 3149 3151 W3159344060.pdf 1 21 contact 0.9930594 "Jusni Ambo Upe, Doctorate Degree, Department of Management, Economic and Business Faculty, Hasanuddin University, Indonesia. (Corresponding author)" 3151 3311 W3159344060.pdf 1 22 separator 0.5490593 3311 3312 W3159344060.pdf 1 23 contact 0.9781293 "¶ Andi Aswan, Doctorate Degree, Department of Management, Economic and Business Faculty, Hasanuddin University, Indonesia." 3312 3443 W3159344060.pdf 1 24 separator 0.9586854 ¶ 3443 3445 W3159344060.pdf 1 25 paratext 0.92844826 "This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International license , which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. www.businessperspectives.org" 3445 3745 W3159344060.pdf 1 26 contact 0.7778601 "LLC “СPС “Business Perspectives” Hryhorii Skovoroda lane, 10, Sumy, 40022, Ukraine" 3745 3833 W3159344060.pdf 1 27 paratext 0.73514426 BUSINESS PERSPECTIVES 3833 3854 W3159344060.pdf 1 28 separator 0.78085715 ¶ 3854 3856 W3159344060.pdf 1 29 paratext 0.8299694 JEL Classification M31, Q12, Q130Keywords 3856 3898 W3159344060.pdf 1 30 text 0.31507325 corn producer 3898 3912 W3159344060.pdf 1 31 title 0.26322737 s 3912 3913 W3159344060.pdf 1 32 text 0.28797096 , intermedi 3913 3924 W3159344060.pdf 1 33 title 0.25228903 ary 3924 3927 W3159344060.pdf 1 34 text 0.2765324 trader 3927 3934 W3159344060.pdf 1 35 table 0.26265907 s 3934 3935 W3159344060.pdf 1 36 text 0.31856138 , margin, 3935 3944 W3159344060.pdf 1 37 paratext 0.28555673 ¶ 3945 3947 W3159344060.pdf 1 38 text 0.31987146 marketing efficiency 3947 3968 W3159344060.pdf 1 39 paratext 0.28317708 , 3968 3969 W3159344060.pdf 1 40 text 0.26678315 marketing 3969 3979 W3159344060.pdf 1 41 paratext 0.31022936 channel 3979 3987 W3159344060.pdf 1 42 separator 0.99297833 ¶ 3987 3989 W3159344060.pdf 1 43 title 0.7679189 Conflict of interest statement 3989 4020 W3159344060.pdf 1 44 paratext 0.49298078 : 4020 4021 W3159344060.pdf 1 45 separator 0.9666422 ¶ 4023 4025 W3159344060.pdf 1 46 text 0.7668774 Author(s) reported no conflict of interest 4025 4068 W3159344060.pdf 1 0 text 0.9963112 "common enrichment pathways, such as glycolysis, MTORC1 signaling, steroid biosynthesis, peroxidase, and ubiquitinationbinding, which are closely related to cancer cell metabolism. It is well known that altered metabolism is one of the hallmarks of cancer. Numerous cancer cells rely on aerobic glycolysis fornutrients and energy ( 57).The activation of SREBP1 by mTORC1 in BC cells inhibits adipogenesis and interferes with cancer cellproliferation and tumor growth ( 58). Additionally, BC is a malignancy in which steroid hormones drive cellular proliferation, such as the sex steroid hormones estrogen receptor (ER) and progesterone receptor (PR), which areimportant prognostic and predictive markers for BC ( 59)." 0 730 W4283024370.pdf 10 1 separator 0.9833209 ¶ 730 732 W4283024370.pdf 10 2 text 0.9996138 "Although miR-340 and miR-185 have been reported as tumorsuppressor miRNAs, the mechanism by which miR-340 andmiR-185 targeting CDH1 has not been investigated, and furtherstudies are required to determi ne the oncogenic regulatorymechanism. Of note, CDH1 co-overexpression in combination with miR-20a was highly enriched mainly in histonemethyltransferase activity, MYC targets V2, WNT/BETA- CATENIN signaling and ribosomes. Among them, MYC and WNT/BETA-CATENIN signalin g pathways are important regulatory pathways for cancer stem cell self-renewal ( 4,60)." 732 1298 W4283024370.pdf 10 3 separator 0.97730327 ¶ 1298 1300 W4283024370.pdf 10 4 text 0.99965775 "Recent studies have reported that histone methyltransferaseEZH2 plays a critical role in maintaining ovarian CSCstemness ( 61). Glioma cells acquire stem-like characters by extrinsic ribosome stimuli ( 62). This indicates that the potential oncogenic mechanism of miR-20a-targeted regulationof CDH1 may be intricately linked with the stemness progressionof BC, which warrants further investigation." 1300 1703 W4283024370.pdf 10 5 separator 0.9683477 ¶ 1703 1705 W4283024370.pdf 10 6 text 0.99771255 "Fourth, we provide convincing experimental evidence supporting that sE-cad, which is formed by the secretion ofCDH1-encoded E-cad into serum and combined with miR-" 1705 1871 W4283024370.pdf 10 7 separator 0.7948957 ¶ 1871 1873 W4283024370.pdf 10 8 text 0.7481008 "A B C D EF GH I" 1873 1893 W4283024370.pdf 10 9 separator 0.9939944 ¶ 1893 1895 W4283024370.pdf 10 10 caption 0.9954113 "FIGURE 6 | The diagnostic signi ficances of sE-cad and miR-340, miR-185, miR-20a in BC. (A–C)The ROC curves for the diagnostic value of the CDH1, miR-340, miR-185, and miR-20a in BC. (D–G)Serum miR-340, miR-185, miR-20a, and sE-cad expression levels in BC patients and healthy subjects. (H)sE-cad in serum levels of BC patients at different stages. (I)ROC curves of sE-cad in combination with miR-20a diagnostic model. * P< 0.05; ** P< 0.01; *** P< 0.001. no signi ficant difference.Xie et al. Roles of CDH1 in BC" 1895 2413 W4283024370.pdf 10 11 separator 0.95668447 ¶ 2413 2415 W4283024370.pdf 10 12 paratext 0.97818756 Frontiers in Endocrinology | www.frontiersin.org June 2022 | Volume 13 | Article 916469 11 2415 2506 W4283024370.pdf 10 0 paratext 0.99035037 Metals 2023 ,13, 711 11 of 22 0 29 W4362610990.pdf 10 1 separator 0.994936 ¶ 29 31 W4362610990.pdf 10 2 text 0.99951625 "Once the welding process has started, the modeling of as many parameters as possible must be as efficient and fast as can be achieved, and for this, it must be done in real time to detect any possible defect in order to be able to correct it and evaluate the quality of the weld on the spot. To this end, we must tend towards dynamic modeling, which models the weld through the parameters derived from dynamic equations (such as the melting speed equation [ 95]), and towards simple but effective modeling in real time, through monitoring, in which, for example, the wire feed is modeled by monitoring the width of the weld bead [62]." 31 679 W4362610990.pdf 10 3 separator 0.99649453 ¶ 679 681 W4362610990.pdf 10 4 title 0.99231625 4. Monitoring Techniques and Its Application 681 726 W4362610990.pdf 10 5 separator 0.99594635 ¶ 726 728 W4362610990.pdf 10 6 text 0.9996129 "It is important to monitor welding parameters during the welding process to ensure that they remain within acceptable limits and to detect any alterations that may result in defects in the weld. Vision techniques, such as cameras and intelligent cameras, and sensors, including sound, vision, integrated vision, radiation, spectral, infrared, and inductive sensors, can be used to read the parameters or variables being measured. These readings can be analyzed in real time through appropriate software to draw conclusions and improve precision, reliability, and efficiency [21]." 728 1319 W4362610990.pdf 10 7 separator 0.82015157 ¶ 1319 1321 W4362610990.pdf 10 8 text 0.9994485 "When alterations to the parameters and predefined modeling procedures are detected, the system should be able to respond, if possible, in real time. Communication between the sensors and control and monitoring systems is necessary to allow for this response." 1321 1583 W4362610990.pdf 10 9 separator 0.65412873 ¶ 1583 1585 W4362610990.pdf 10 10 text 0.9966215 "The consequences of alterations to the parameters can result in defects in the weld, and examples of such defects can be studied using the selected detection methods listed in Table 2." 1585 1774 W4362610990.pdf 10 11 separator 0.99639165 ¶ 1774 1776 W4362610990.pdf 10 12 title 0.84029937 Table 2. Different methods of defect detection through process parameters. 1776 1851 W4362610990.pdf 10 13 separator 0.99207705 ¶ 1851 1853 W4362610990.pdf 10 14 title 0.4980765 Defect 1853 1860 W4362610990.pdf 10 15 table 0.96736085 "Method of Detection Parameter for Detection References Porosity ultrasonic based sensorthe characteristic parameters[96] Porosity monitoring of imagestemperature of the upper surface of the melt pool[97] Porosity monitoring output parameter [41] Porosity, Cracks, lack of fusion, undercutsmonitoring Intensity [72,73] Lack of penetration monitoring spectroscopy signal [70] Lack of penetrationoptical analysis of the plasma spectrumelectronic plasma temperature[48] Lack of penetration monitoring arc voltage signal [88] Emissions (sound and light)monitoring welding arc [98] Tracking defectsmonitoring by a sensor using spectrometryelectronic temperatures [99] In the molten pool monitoring acoustic signals [100] defect classification (based on a decision tree algorithm)monitoring and control current and voltage [31]" 1860 2720 W4362610990.pdf 10 16 separator 0.99032485 ¶ 2720 2722 W4362610990.pdf 10 17 text 0.99879193 "To detect the aforementioned defects, sensors need to be inserted in real time around the welding process, and their presence can alter the behavior of the metal transfer and, consequently, uneven quality [20], as well as increase the cost of production." 2722 2981 W4362610990.pdf 10 18 separator 0.9970585 ¶ 2981 2983 W4362610990.pdf 10 19 title 0.994071 4.1. Bead Tracking, Weld Dimension, and Defects Monitoring and Control 2983 3054 W4362610990.pdf 10 20 separator 0.9957198 ¶ 3054 3056 W4362610990.pdf 10 21 text 0.9949658 "Bead tracking and weld dimension control are essential tasks for ensuring the quality and accuracy of robotic welding processes. Bead tracking involves detecting the position and geometry of the weld seam using various sensors, such as laser, vision, or arc sensors. Weld dimension control involves adjusting the welding parameters, such as wire feed rate and voltage, according to the feedback from the sensors and the desired weld bead shape." 3056 3509 W4362610990.pdf 10 0 paratext 0.9819556 Journal of Management Info Vol. 3, No. 2 (2016) 1-6 0 51 W2529985646.pdf 5 1 separator 0.94259584 ¶ 52 54 W2529985646.pdf 5 2 paratext 0.9602687 Copyright © 2018 Authors. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. 6 55 298 W2529985646.pdf 5 3 separator 0.9909165 ¶ 299 301 W2529985646.pdf 5 4 bibliography 0.9973695 Evidence from El Salvador.ǁ Journal of Development Economics 72(2): 429–61 Hanson, G. and Woodruff, Ch. (2003) ―Emigration and Educational Attainment in Mexico.ǁ Working Paper. University of California-San Diego Yang, D. (2004) ―International Migration, Human Capital, and Entrepreneurship: Evidence from Philippine Migrant‘s Exchange Rate Shocks.ǁ Research Program on International Migration and Development. DECRG. Policy Research Working Paper 3578. World Bank Asmaa Elbadawy and Rania Roushdy (2009) “Impact of International Migration and Remittances on Child Schooling and Child Work: The Case of Egypt” Population Council, MENA regional office. Addleton j. (1984). “The impact of migration on economic development in Pakistan,” Asian survey, vol. 24. No, 5:574-596 Siegmann A. K. (2010) “” progress and development studies, 1 strengthening whom, the role of international migration for women and men in North West Pakistan,0: 345 301 1257 W2529985646.pdf 5 0 paratext 0.9897981 Sensors 2017 ,17, 2784 4 of 6 0 29 W2771625634.pdf 3 1 separator 0.9925265 ¶ 29 31 W2771625634.pdf 3 2 text 0.98594254 "Furthermore, we prepared simulated seawater with fixed a NaSO 4concentration (28.00 mmol/L) and different NaHCO 3concentrations (0.00, 2.00, 4.00 mmol/L) to evaluate its ability to quantify HCO 3" 31 229 W2771625634.pdf 3 0 paratext 0.9710495 7 0 1 W4396577285.pdf 15 1 separator 0.86519027 ¶ 1 3 W4396577285.pdf 15 2 paratext 0.9522543 21 3 6 W4396577285.pdf 15 3 separator 0.99636036 ¶ 6 8 W4396577285.pdf 15 0 paratext 0.8755497 2 Journal of T ropical Medicine 0 31 W2084478141.pdf 1 1 separator 0.989836 ¶ 31 33 W2084478141.pdf 1 2 title 0.9868069 "Ta ble 1: Comparison of hospital (clinical) and medicolegal autop- sies." 33 108 W2084478141.pdf 1 3 separator 0.99353063 ¶ 108 110 W2084478141.pdf 1 4 table 0.9942368 "Type of autopsy Number of cases (%) Hospital 3 (1.8%) Medicolegal 163 (98.2%)T otal 166" 110 202 W2084478141.pdf 1 5 separator 0.9920126 ¶ 202 204 W2084478141.pdf 1 6 title 0.9831825 "Ta ble 2: Comparison of diagnosis between antemortem and postmortem reports." 204 283 W2084478141.pdf 1 7 separator 0.9841157 ¶ 283 285 W2084478141.pdf 1 8 table 0.9955128 "Diagnosis Number of cases (%) Same 52 (31.3%) Different 106 (63.9%) Nil 8 (4.8%)T otal 166" 285 381 W2084478141.pdf 1 9 separator 0.98757505 ¶ 381 383 W2084478141.pdf 1 10 text 0.99948525 "Rare disease presentations have occasionally only been diagnosed after autopsies and patients’ relatives after autop-sies are better informed on cause of death. Rare diseases withgenetic inheritance detected through autopsies have served asa tool for genetic counseling, screening, and monitoring ofrelatives. Hospital managements have used autopsy reports to identify malpractices, professional misconducts and occa- sionally to give statements for compensation of victims." 383 864 W2084478141.pdf 1 11 separator 0.87739277 ¶ 864 866 W2084478141.pdf 1 12 text 0.9996657 "Autopsy is relevant in occupational health as cause of death can determine whether victims deserve compensationor not. Many disciplinary committees in the health profes-sion have found autopsy useful for their judgments. Manycongenital anomalies have been defined in cases of stillbirthsof unexplained aetiopathogenesis. This has helped geneticcounseling." 866 1223 W2084478141.pdf 1 13 separator 0.90013206 ¶ 1223 1225 W2084478141.pdf 1 14 text 0.99955547 "Autopsy is also a tool employed in Medicine to train doctors in Forensic Medicine. This has helped medicaltraining, improved interest in the field of pathology as aspecialty, and sharpened diagnostic acumen of medical prac-titioners. The numerous surprises seen from autopsy resultshave humbled practitioners against unnecessary heroism andunethical practices in medicine. Autopsy findings have alsoled to evolution of innovative diagnostic technologies to helpdoctors improve diagnosis and management of patients." 1225 1740 W2084478141.pdf 1 15 separator 0.99729663 ¶ 1740 1742 W2084478141.pdf 1 16 title 0.9919531 2. Materials and Methods 1742 1767 W2084478141.pdf 1 17 separator 0.99667454 ¶ 1767 1769 W2084478141.pdf 1 18 text 0.98759156 "This retrospective study was carried out in Jos UniversityT eaching Hospital (JUTH) Jos, North Central Nigeria. Approval was obtained from the Ethical Clearance Com- mittee of the Jos University T eaching Hospital." 1769 1988 W2084478141.pdf 1 19 separator 0.5001788 ¶ 1988 1990 W2084478141.pdf 1 20 text 0.9984292 "The pathology department of this hospital has five pathologists who cater for the autopsy services of thehospital, the missionary, and numerous private hospitals inthe state. They are also consulted for their service by hospitalsfrom neighboring states of Nassarawa, Bauchi, and Benue.Data was obtained from the records section of the pathologydepartment of JUTH. It comprised the autopsy reports andthe clinical diagnosis obtained from the attending physicians.Ta ble 3: Medicolegal and hospital autopsies with their correspond- ing antemortem diagnosis found helpful to law enforcement agentsand clinicians." 1990 2603 W2084478141.pdf 1 21 separator 0.99645126 ¶ 2603 2605 W2084478141.pdf 1 22 table 0.9174262 "Antemortem Postmortem Drowning Strangulation (homicide) Sudden death? CauseCerebrovascular accident (Hemorrhagic stroke) Typhoid fever Bacterial meningitisHemorrhagic shock? Cause Bleeding peptic ulcer disease Multiple fractures from accidental fall from heightStrangulation (homicidal) Disseminated tuberculosis Meig’s Syndrome Sudden death? Cause Ruptured Ectopic pregnancy Typhoid Septicaemia Viral hemorrhagic fever" 2605 3043 W2084478141.pdf 1 23 separator 0.9965995 ¶ 3043 3045 W2084478141.pdf 1 24 title 0.98935056 3. Results 3045 3056 W2084478141.pdf 1 25 separator 0.99566764 ¶ 3056 3058 W2084478141.pdf 1 26 text 0.9926477 "A total of 166 cases were studied. One hundred and sixty three (98.2%) cases were medicolegal cases while only 3(1.8%) were clinical autopsies (T able 1). Ta b l e 2shows the di fference between antemortem and postmortem diagnosis to be di fferent in 106 (63.9%), same in 52 (31.3%), and nil in 8 (4.8%) of the cases. Ta b l e 3shows examples of varying diagnosis antemortem and postmortem." 3058 3459 W2084478141.pdf 1 27 separator 0.9968393 ¶ 3459 3461 W2084478141.pdf 1 28 title 0.9895656 4. Discussion 3461 3475 W2084478141.pdf 1 29 separator 0.9963008 ¶ 3475 3477 W2084478141.pdf 1 30 text 0.99947506 "Ta b l e 1shows the total number of autopsies performed, medicolegal autopsies accounted for 163 (98.25) whilehospital autopsies accounted for only 3 (1.8%). This showsthat requests for autopsies by clinicians are very low. This isconsistent with records in Europe and other parts of Africa[4,5]. The low rate of hospital autopsies might be due to lack of skills in obtaining consent from relatives by clinicians,reluctance by clinicians to request for autopsies, adventof sophisticated diagnostic machines, fear of litigation,reluctance by clinicians to avail self for medical auditing, lackof pathologists. In Africa, sophisticated diagnostic machinesare few or almost nonexistent thus making diagnosis byclinicians di fficult antemortem. This calls for the need to request for autopsies for medical auditing to sharpen clinicalacumen. Friedlander reported that autopsy results have beenable to aid by obtaining confirmative diagnosis of patients [6]." 3477 4436 W2084478141.pdf 1 31 separator 0.8518127 ¶ 4436 4438 W2084478141.pdf 1 32 text 0.9997147 "Ta b l e 2shows that in 63.9% of cases, diagnosis by pathologists after an autopsy was very di fferent from that by clinician antemortem. This high rate is similar to that foundby Friedlander and Diegbe et al. [ 4,7]. The superiority of autopsy diagnosis over antemortem diagnosis was observedby Heller et al. in England [ 4]." 4438 4770 W2084478141.pdf 1 33 separator 0.76749504 ¶ 4770 4772 W2084478141.pdf 1 34 text 0.99942845 "These errors may or may not a ffect the survival outcome of subjects and are classified by Goldman as major or minorwhich may be either class I, II, III, or IV errors [ 8]." 4772 4945 W2084478141.pdf 1 35 separator 0.74093455 ¶ 4945 4947 W2084478141.pdf 1 36 text 0.9995196 "The Class II errors obtained in this study, which are missed major diagnosis that had no impact on survival andwould not have changed therapy, were 7.5% (T able 3)." 4947 5114 W2084478141.pdf 1 0 text 0.9996835 "If the shell mass fraction was 0.9, the Ko ̈hler curves in models 1 and 3 nearly overlapped because the hygroscopicity was mainly determined by the mass fraction of the soluble shell. In this mass fraction, the critical supersaturation was 0.15%. The Ko ̈hler curve in model 2 changed significantly; the particles began to absorb water vapor at a very high supersaturation (1.8%) and then the supersaturation decreased when the particles grew until the supersat- uration was 0.27%. After that, the supersaturation continued to increase and achieved an extreme point (0.3%) and dropped down again, which meant thesolution droplet was activated at 0.3% supersatura- tion. The critical supersaturation for models 1, 2 and 3 was 0.15%, 1.8% and 0.15%, respectively." 0 785 W4224030296.pdf 4 1 separator 0.98596096 ¶ 785 787 W4224030296.pdf 4 2 text 0.99947596 "At the same size and shell mass fraction, the critical supersaturation in model 3 was lowest, followed by that in model 1, while that in model 3 was the highest. The mass fraction of the soluble component greatly influenced the critical supersaturation." 787 1050 W4224030296.pdf 4 3 separator 0.99706733 ¶ 1050 1052 W4224030296.pdf 4 4 title 0.99409 3.2. Particle Size and Critical Supersaturation 1052 1100 W4224030296.pdf 4 5 separator 0.99608433 ¶ 1100 1102 W4224030296.pdf 4 6 text 0.99965966 "Critical supersaturation from each Ko ̈hler curve for each dry particle was extracted and a figure of critical supersaturations as a function of dry particle sizes was produced for the three core-shell models, as shown in Fig. 2. Shell mass fractions of 0.01, 0.1, 0.5 and 1 were mainly considered (Fig. 2). Shell mass fraction 0.01 meant fresh particles without evident heterogeneous chemical reaction; fraction 0.1 and 0.5meant particles at different aging levels through heterogeneous chemical reactions; those with fraction 1 represented particles composed totally by pure inorganic or organic components." 1102 1731 W4224030296.pdf 4 7 separator 0.96752053 ¶ 1731 1733 W4224030296.pdf 4 8 text 0.99960047 "As Fig. 2shows, critical supersaturation in model 3 was the lowest at the same size and shell mass fraction followed by that in model 1. The activation diameter in model 3 was lowest under the same supersaturation and shell mass fraction followed bymodel 1." 1733 1999 W4224030296.pdf 4 9 separator 0.8932689 ¶ 1999 2001 W4224030296.pdf 4 10 text 0.99945784 "For example, under 0.1% supersaturation, the activation diameter was 580, 270, 160 and 120 nm, respectively, at shell mass fractions of 0.01, 0.1, 0.5 and 1 for particles in model 1 (Fig. 2a) and 280, 190, 150 and 120 nm at shell mass fractions of 0.01, 0.1,0.5 and 1, respectively, for particles in model 3 (Fig. 2c)." 2001 2330 W4224030296.pdf 4 11 separator 0.9749023 ¶ 2330 2332 W4224030296.pdf 4 12 text 0.99974555 "For model 2 (Fig. 2b), particles were quite hard to activate. At shell mass fractions of 0.01 and 0.1, only particles [1lm could be activated at 0.1% super- saturation, while bigger particles could not be suspended in air for a long time, so they seldom influenced clouds or precipitation. At shell mass fractions of 0.5 and 1, the activation diameters were 860 and 530 nm at 0.1% supersaturation." 2332 2743 W4224030296.pdf 4 13 separator 0.92294383 ¶ 2743 2745 W4224030296.pdf 4 14 text 0.99950397 "Comparing the three models, more particles in model 1 and 3 could be activated into water dropletsthan those in model 2." 2745 2868 W4224030296.pdf 4 15 separator 0.9967332 ¶ 2868 2870 W4224030296.pdf 4 16 title 0.9935481 3.3. Mass Fraction and Supersaturation 2870 2909 W4224030296.pdf 4 17 separator 0.9964294 ¶ 2909 2911 W4224030296.pdf 4 18 text 0.9997375 "Critical supersaturation as a function of shell mass fraction is shown in Fig. 3. As Fig. 3shows, the higher the shell mass fraction, the lower the critical supersaturation was for a certain size particle. For models 1 and 3, critical supersaturation decreasedvery fast when shell the mass fraction increased, especially when the shell mass fraction changed from 0 to 0.1 (Fig. 3a–c). For example, when the shell mass fraction increased from 0 to 0.1, the critical supersaturation of 100 nm particles in model 1 decreased from 2% to 0.5%. When the shell mass fraction increased from 0.1 to 0.2, the critical supersaturation decreased from 0.5% to 0.35% (Fig. 3b). Similar changes also took place in the particles in model 3. This meant that the inorganic shell could make particles more hygroscopic andCCN active." 2911 3753 W4224030296.pdf 4 19 separator 0.9705764 ¶ 3753 3755 W4224030296.pdf 4 20 text 0.990154 "For particles in model 2 (Fig. 3b), the critical supersaturation decreased slowly with particle size. When the shell mass fraction increased from 0 to 1, the critical supersaturation of 100-nm particles in model 2 slowly dropped from 2.1% to 1.9%. This meant that the organic shell could not efficiently change particle hygroscopicity." 3755 4104 W4224030296.pdf 4 21 separator 0.9499128 ¶ 4104 4106 W4224030296.pdf 4 22 text 0.9966621 "Comparing the figures of different sizes (Fig. 3a– c), under a constant shell mass fraction, critical supersaturation was lower when the sizes were higher." 4106 4267 W4224030296.pdf 4 23 paratext 0.9757821 Vol. 179, (2022) Study of Cloud Condensation Nuclei Activities and Hygroscopic Properties 1425 4267 4361 W4224030296.pdf 4 0 paratext 0.6246446 344 КРИМІНАЛЬНЕ ПРАВО ТА КРИМІНОЛОГІЯ ; 0 68 W4285689120.pdf 5 1 title 0.66653025 КРИМІНАЛЬНО -ВИКОНАВЧЕ ПРА ВО 68 98 W4285689120.pdf 5 2 separator 0.98834354 ¶ ¶ 99 105 W4285689120.pdf 5 3 text 0.996684 "ЮРИДИЧНА НАУКА No 7(109)/20 20 ст. 246 КК України, найчастіше виступають листяні дерева породи «Дуб»; у «Кутському лісовому господарстві» – листяні дерева породи «Бук»; у «Свалявадержспецлісгоспі» – листяні дерева порід «Бук», «Береза»; у «Тернопільлісі», у «Солотвинському лісгоспі» – хвойні дерева породи «Сосна»; у державному ландшафтному заказнику загальнодержавного значення «Пікуй», що належить до об ’єктів природно -заповідного фонду, – хвойні дерева порід «Смерека», «Ялиця»; тощо." 125 639 W4285689120.pdf 5 4 separator 0.95597655 ¶ 641 643 W4285689120.pdf 5 5 text 0.99782145 "Більше того, за результатами вивчення матеріалів кримінальних проваджень стосовно вчинених організованими злочинними формуваннями кримінальних правопорушень, передбачених ст. ст. 2011 і 246 КК України, у 98,11 % випадків предметом злочину були дерева, а 1,89 % – чагарники. При цьому основна масова частка припадає на твердолистяні дерева (59,43 %) порід дуб, бук, береза, ясен, вільха, і значно менша на хвойні дерева (38,7 %) порід сосна, смерека, ялиця." 643 1123 W4285689120.pdf 5 6 separator 0.9827633 ¶ 1125 1127 W4285689120.pdf 5 7 text 0.99764436 "Висновки. Отже, предметом незаконної порубки і контрабанди лісу, вчиненої організованою злочинною групою, є сиророслі та сухостійні дерева чи чагарники, що ростуть у лісах, захисних та інших лісових насадженнях, у заповідниках або на територіях та об ’єктах природно -заповідного фонду. За результатами ви вчення матеріалів кримінальних проваджень стосовно вчинених організованими злочинними формуваннями кримінальних правопорушень, передбачених ст. ст. 2011 і 246 КК України, у 98,11 % випадків предметом злочину були дерева, а 1,89 % – чагарники. При цьому осн овна масова частка припадає на твердолистяні дерева (59,43 %) порід дуб, бук, береза, ясен, вільха, і значно менша на хвойні дерева (38,7 %) порід сосна, смерека, ялиця." 1127 1895 W4285689120.pdf 5 8 separator 0.9967655 ¶ 1897 1899 W4285689120.pdf 5 9 title 0.9862313 СПИСОК ВИКОРИСТАНИХ ДЖЕРЕЛ 1899 1926 W4285689120.pdf 5 10 separator 0.9927255 ¶ 1928 1930 W4285689120.pdf 5 11 bibliography 0.99687207 "1. Пчеліна О.В. Теоретичні засади формування та реалізації методики розслідування злочинів у сфері службової діяльності: дис. ... д -ра юрид. наук: 12.00.09. Харків, 2017. 571 с." 1930 2116 W4285689120.pdf 5 12 separator 0.9522075 ¶ 2117 2119 W4285689120.pdf 5 13 bibliography 0.99676204 "2. Панов М.М. Кримінальна відповідальність за незаконні дії з документами на переказ, платіжними картками та іншими засобами доступу до б анківських рахунків, обладнанням для їх виготовлення: дис. ... канд. юрид. наук: 12.00.08. Харків, 2006. 194 с." 2119 2378 W4285689120.pdf 5 14 separator 0.96507245 ¶ 2379 2381 W4285689120.pdf 5 15 bibliography 0.9966547 "3. Кримінальний кодекс України: закон України від 05.04.2001 No 2341 –ІІІ. Відомості Верховної Ради України . 2001. No 25. Ст. 131." 2381 2518 W4285689120.pdf 5 16 separator 0.9573639 ¶ 2520 2522 W4285689120.pdf 5 17 bibliography 0.99759036 "4. Бурлака П. Ві дмежування незаконної порубки лісу від деяких інших кримінальних правопорушень. Вісник прокуратури. 2018. No 10. С. 43–53." 2522 2667 W4285689120.pdf 5 18 separator 0.9792111 ¶ 2668 2670 W4285689120.pdf 5 19 bibliography 0.9962703 "5. Про особливості державного регулювання діяльності суб ’єктів підприємницької діяльності, пов ’язаної з реалізацією та експортом лісоматеріалів: закон України від 08.09.2005 No 2860 -ІV. Відомості Верховної Ради України. 2006. No 2–3. Ст. 34." 2670 2925 W4285689120.pdf 5 20 separator 0.9488153 ¶ 2926 2928 W4285689120.pdf 5 21 bibliography 0.9971166 6. Лісовий кодекс України: закон України від 21.01.1994 No 3852 -ХІІ. 2928 2998 W4285689120.pdf 5 22 separator 0.9722712 ¶ 2999 3001 W4285689120.pdf 5 23 bibliography 0.99625635 Відомості Верховної Ради України. 1994. No 17. Ст. 99. 3001 3057 W4285689120.pdf 5 0 paratext 0.9902422 Future Internet 2022 ,14, 251 11 of 19 0 38 W4292998846.pdf 10 1 separator 0.9966713 ¶ 38 40 W4292998846.pdf 10 2 caption 0.97503287 Figure 5. Hierarchical mean feature importance for ETHUSD. 40 99 W4292998846.pdf 10 3 separator 0.994064 ¶ 99 101 W4292998846.pdf 10 4 text 0.9985288 "The outermost circular crown of the pie chart in Figure 2 reports the average impor- tance scores per feature by considering all cryptocurrencies. Specific price-related features, such as close_resid (i.e., the Seasonal-Trend decomposition using LOESS of the closing price series [ 30], have shown to be the most relevant to predict future cryptocurrency prices)." 101 470 W4292998846.pdf 10 5 separator 0.89137995 ¶ 470 472 W4292998846.pdf 10 6 text 0.9995591 "However, the selected features are not the same for all cryptocurrencies and also include blockchain-related ones. For example, hashrate _pct, which indicates the amount of com- putational operations that a miner or the network of miners is capable of carrying out, is particularly relevant to BitCoin casH (BCH), which has been created to specifically address efficiency issues of the most established BTC cryptocurrency. Conversely, it is not relevant to Ethereum (ETH) because ETH is known to be weakly correlated to BTC." 472 1005 W4292998846.pdf 10 7 separator 0.9707845 ¶ 1005 1007 W4292998846.pdf 10 8 text 0.99917996 "To have a higher-level view of which features are more discriminating for a given cryp- tocurrency, we also aggregate the feature importance scores per subcategory and category (see the two inner crowns in Figure 2 and the bar charts). The most relevant features are those belonging to category Blockchain (average score 0.48), which is followed by Market data (0.46) and Technical analysis features (0.16). This means that to drive their investments, cryptocurrency traders should closely monitor blockchain-related features first rather than simply analyzing price-related features (e.g., moving averages, momentum [27])." 1007 1642 W4292998846.pdf 10 9 separator 0.9704766 ¶ 1642 1644 W4292998846.pdf 10 10 text 0.9993127 "Focusing on the most influential subcategories, they encompass the properties of the supply chain, namely Supply (BC category), the historical cryptocurrency prices, i.e., History (MD category), and the blockchain network activity metrics, namely Addresses (BC category)." 1644 1919 W4292998846.pdf 10 11 separator 0.69628525 ¶ 1919 1921 W4292998846.pdf 10 12 text 0.99949324 "It is worth noticing that restricting the in-depth analysis to these feature subsets allows experts to ignore almost 70% of the original features." 1921 2070 W4292998846.pdf 10 13 separator 0.9737222 ¶ 2070 2072 W4292998846.pdf 10 14 text 0.9994353 "The variability in feature importance across different cryptocurrencies is also quite significant (see Figures 3–5). For example, for ETHUSD, the blockchain-related features turn out to be slightly less significant than for BTCUSD and BCHUSD, which is possibly due to the primary influence of the blockchain architecture on the price movements of the BiTCoin-related assets. Ethereum (ETH) is partly uncorrelated with BC and weakly dependent on blockchain-related properties such as hash rate and transaction counts." 2072 2596 W4292998846.pdf 10 0 text 0.9821015 "акцентируют внимание на том, что тогдашнее самоуправление пыталось преодолеть идентичные с нынешними проблемы – коррупцию, отсутствие управленческих кадров, жесткий контроль государственных органов власти за его деятельностью." 0 238 W3120877428.pdf 26 1 separator 0.95460117 ¶ 239 241 W3120877428.pdf 26 2 text 0.9487253 "В выводах установлены основные тенденции, обозначены достижения и круг недостаточно исследованных проблем, определены основные направления дальнейшего изучения становления и функционирования городского самоуправления в имперский период." 241 490 W3120877428.pdf 26 3 separator 0.9906908 ¶ 491 493 W3120877428.pdf 26 4 text 0.5821351 "Ключевые слова : городское самоуправление, историография, Надднепр" 493 563 W3120877428.pdf 26 5 title 0.43566734 я 563 564 W3120877428.pdf 26 6 text 0.69643164 "нская Украина, Российская империя, реформы, имперский период." 564 628 W3120877428.pdf 26 7 separator 0.9929842 ¶ 629 631 W3120877428.pdf 26 8 paratext 0.59518707 83 631 634 W3120877428.pdf 26 9 title 0.41548586 Grant charter to the cities and city charters of 634 683 W3120877428.pdf 26 10 paratext 0.3529042 1870 683 688 W3120877428.pdf 26 11 title 0.38118297 and 688 692 W3120877428.pdf 26 12 paratext 0.43251982 1892 692 697 W3120877428.pdf 26 13 title 0.36949682 in 697 702 W3120877428.pdf 26 14 separator 0.23990521 ¶ 702 703 W3120877428.pdf 26 15 title 0.39496768 modern 703 710 W3120877428.pdf 26 16 paratext 0.40709952 national 710 719 W3120877428.pdf 26 17 title 0.46008825 historiography 719 734 W3120877428.pdf 26 18 separator 0.9896381 ¶ 735 737 W3120877428.pdf 26 19 paratext 0.56000745 © 737 739 W3120877428.pdf 26 20 contact 0.6339332 Bondarenko Oleksandr 739 760 W3120877428.pdf 26 0 paratext 0.9904182 Int. J. Mol. Sci. 2022 ,23, 8957 5 of 18 0 40 W4290963498.pdf 4 1 separator 0.9878625 ¶ 40 42 W4290963498.pdf 4 2 text 0.9995801 "on an unusual cycloaddition-cycloreversion sequence [ 42]. To this end, we prepared the penta-substituted benzene derivative 16starting from the tri-substituted phenol derivative 9(Scheme 2), exploiting the well-known ability of the OTHP as an ortho-directing group for the metalation [ 43]. Accordingly, compound 9was promptly transformed into the corresponding tetrahydropyranyl ether 14that was at first ortho-lithiated by treatment with BuLi and later reacted with DMF to give the tetra-substituted phenyl derivative 15." 42 576 W4290963498.pdf 4 3 separator 0.91209215 ¶ 576 578 W4290963498.pdf 4 4 text 0.99971867 "The subsequent bromination para to the phenol group [ 44] afforded the desired penta- substituted benzene 16, to which the O-ethoxycarbonylmethylene fragment was easily inserted by standard etherification reaction. In previous saponification, compound 17was treated with the Ac 2O-AcONa system with heating to give the required 5-bromo benzofuran derivative 12in an appreciable 57% yield. The mechanism proposed for the interesting cyclization reaction entails dehydration of the carboxyl group to give an unstable ketene intermediate that is trapped intramolecularly by the formyl group. The thermal [2 + 2] heterocycloaddition reaction is followed by a cycloreversion with the expulsion of CO 2and production of the 2,3-unsubstituted benzofuran derivative 12[42]." 578 1358 W4290963498.pdf 4 5 separator 0.98379743 ¶ 1358 1360 W4290963498.pdf 4 6 text 0.9995597 "Having the suitably derivatized aryl ring-B moiety in hand, we conceived preparing compound 1by exploiting the Mizoroki-Heck cross-coupling reaction between 12and 1-phenyl-2-propen-1-one 13. The latter reagent was, in turn, easily prepared by react- ing phosphorous ylide 8and formaldehyde according to a known Wittig protocol [ 45] (Scheme 2). Disappointingly, the Pd(0)-catalyzed reaction provided the retrochalcone 1 with a modest 32% yield [46]." 1360 1820 W4290963498.pdf 4 7 separator 0.99699795 ¶ 1820 1822 W4290963498.pdf 4 8 title 0.9943035 2.3. Synthetic Pathways Providing the Non-Natural Regioisomers of Velutone F 1822 1899 W4290963498.pdf 4 9 separator 0.99498725 ¶ 1899 1901 W4290963498.pdf 4 10 text 0.99970144 "With the aim of learning about stereo-electronic properties of the hybrid benzofuran- retrochalcone scaffold, we decided to prepare the non-natural compounds 22,23,and 28 featuring the PhP moiety attached, respectively, at C-2, C-6, and C-3 of the 4,7-dimethoxy benzofuran core ( BF). The non-natural regioisomers of velutone F are previously un- known compounds." 1901 2273 W4290963498.pdf 4 11 separator 0.9969781 ¶ 2273 2275 W4290963498.pdf 4 12 title 0.9937274 2.3.1. Synthetic Pathways to the Isomers 22 and 23 2275 2326 W4290963498.pdf 4 13 separator 0.99573624 ¶ 2326 2328 W4290963498.pdf 4 14 text 0.9997399 "The direct formylation of electron-rich arenes can be conveniently accomplished via the Vilsmeier–Haack (V–H) reaction. Indeed, the benzo[b]furan nucleus is reported to yield the 2-formyl derivative by reaction with the V–H electrophilic species [ 47]. We anticipated that the regioselectivity of the V–H reaction could change if electron-donating groups were present on the phenyl ring of the benzo-fused system. In line with our hypothesis, we decided exploring the behavior of 4,7-dimethoxy benzo[b]furan 19under V-H reaction conditions (Scheme 3). We planned to build the substituted benzo[b]furan 19from 9by creating the annellated 2,3-unsubstituted furan ring according to our previously sound synthetic pathway B for target compound 1(Scheme 2). Thus, once etherified the phenolic group of 9with the functionalized two carbon fragment, the resulting compound 18was cyclized to 19under the action of PPA (Sn- zeolite also showed to efficiently promote this transformation [ 48]). As expected, we found the subsequent electrophilic aromatic substitution reaction was poorly regioselective: all but one of the regioisomeric formyl benzofuran derivatives 2-FBF ,5-FBF , and 6-FBF were formed. In detail, chromatographic purification of the residue from the V-H reaction led us to isolate compounds 20(2-FBF ) together with 7(5-FBF ) in 37% yield (1H NMR and HPLC analysis showed the isomers were in a 3.5:6.5 ratio), and compound 21(6-FBF ) in 30% yield. At this stage, we submitted the separated fractions to the Wittig olefination with the stabilized phosphorous ylide 8." 2328 3936 W4290963498.pdf 4 15 separator 0.9166059 ¶ 3936 3938 W4290963498.pdf 4 16 text 0.999587 "We obtained chalcone 23from 6-FBF , while in the same manner, the inseparable mixture of2-FBF and 5-FBF furnished chalcones 22and 1, which, gratifyingly, could be easily separated by column chromatography." 3938 4148 W4290963498.pdf 4 0 paratext 0.9827027 1756 Theoretical and Applied Genetics (2019) 132:1745–1760 0 58 W2920009442.pdf 11 1 separator 0.64940584 ¶ 58 60 W2920009442.pdf 11 2 paratext 0.98601127 1 3 60 64 W2920009442.pdf 11 3 separator 0.9732426 ¶ 64 66 W2920009442.pdf 11 4 text 0.9982092 "encompass both loci that show favourable effect, i.e. improvement in either protein content or grain yield with-out a negative effect on other traits but also unfavourable loci that potentially cause the protein content/grain yield trade-off." 66 312 W2920009442.pdf 11 5 separator 0.92029965 ¶ 312 314 W2920009442.pdf 11 6 text 0.99968755 "Addressing this issue, a desired gain index (Pesek and Baker 1969) for genomic selection was employed restrict- ing either the protein content or grain yield and in this way preferably increase the allele frequency of favourable loci that confer an increase in grain yield or protein content with-out negatively influencing the respective other trait. Aside from largely targeting these loci, holding the population average for one of the traits stable also eased the identifica-tion of lines with favourable allele combinations that pos-sess an elevated grain yield with average protein content and increased protein yield even in the presence of strong negative genomic correlation between protein content and grain yield. Preliminary investigations using cross-validation with these genomic selection indices did not show any ben-efit of multivariate models to derive variance–covariance matrices that contain this genomic correlation for calcu-lating appropriate index weights. Furthermore, no added value was observed of using a closely related method that derives genomic selection indices by multiplying the vec-tor of genomic estimated breeding values with the genomic relationship matrix (Ceron-Rojas et al. 2015 ), while a Smith–Hazel index aiming to maximize the net merit (Smith 1936; Hazel 1943) did not lead to desired gain, i.e. main-taining grain yield or protein content but favoured one trait at cost of the other. Accordingly, it can be recommended to focus on genomic selection indices that correspond to deviations from regression line when conducting a simul - taneous selection for grain yield and protein content and for finding the desirable outliers from the common trend, although it should be noticed that other methods such as using the multi-optimization framework by setting optimal compromise solutions or from the Bayesian decision theory have also shown great promise (Akdemir et al. 2018; de Villar-Hernández et al. 2018)." 314 2282 W2920009442.pdf 11 7 separator 0.98620427 ¶ 2282 2284 W2920009442.pdf 11 8 text 0.9991379 "Identification of these outliers is of high interest to breed- ers, and especially, the grain protein deviation has received large attention (Monaghan et al. 2001) and has even become a major criterion for variety registration in France (F. Löschenberger pers.comm.). It is, moreover, associated with post-anthesis nitrogen uptake in bread (Bogard et al. 2010; Latshaw et al. 2016) and durum wheat (Suprayogi et al. 2011) (Table 2). This suggested that selecting genotypes that show superior performance in the genomic selection index based on grain protein deviations potentially enables an indi-rect selection for a difficult to phenotype trait, which might lead to an indirect genetic improvement for this important component of nitrogen-use efficiency in a genomic breeding approach. The underlying genetic base of these deviations from the regression line is furthermore highlighted by a larger grain protein deviation of hybrid wheat in compari-son with line varieties (Thorwarth et al. 2018) that might also be influenced by a different root architecture to improve nitrogen uptake (Cormier et al. 2016; Hawkesford 2017 ) and supposedly causes a larger yield stability for some genotypes (Mühleisen et al. 2014 ; Liu et al. 2017 ). Accordingly, several QTL related to grain protein deviation have been mapped in wheat amongst others in the proximity of major genes like Ppd-D1 regulating photoperiodic sensitivity and the semi- dwarfing genes Rht- B1 and Rht- D1 (Cormier et al. 2014; Guttieri et al. 2017) with some candidate genes being identi-fied (Habash et al. 2007; Li et al. 2011). Notwithstanding, polygenic inheritance with a genetic architecture of many small to medium effect loci renders the reliable identifica-tion of genotypes with large positive grain protein deviation difficult in the framework of genotype-by-environment inter - action making variety testing in multi-environment trials necessary (Oury and Godin 2007), which can additionally be supported by prediction models that characterize environ-ments with respect to nitrogen stress (Ly et al. 2017). No" 2284 4394 W2920009442.pdf 11 9 separator 0.9944898 ¶ 4395 4397 W2920009442.pdf 11 10 title 0.7879324 "Table 2 Phenotypic correlation of protein yield and the presented selection indices with post-anthesis nitrogen uptake and remobilization as well as" 4397 4550 W2920009442.pdf 11 11 table 0.41902524 protein 4550 4558 W2920009442.pdf 11 12 title 0.3814578 4558 4559 W2920009442.pdf 11 13 table 0.43806714 content and grain yield in wheat 4559 4591 W2920009442.pdf 11 14 separator 0.7600068 ¶ 4591 4593 W2920009442.pdf 11 15 text 0.4704279 Performance 4593 4605 W2920009442.pdf 11 16 table 0.54977924 estimates as reported by Bogard et al. (2010) and Latshaw et 4605 4666 W2920009442.pdf 11 17 text 0.6224516 "al. (2016) were used to derive the respective selection indices, while for durum, wheat values were averaged over the three environments reported by Suprayogi et al. (2011). The respective c" 4666 4860 W2920009442.pdf 11 18 table 0.4921119 "orrelation coefficients ob" 4860 4889 W2920009442.pdf 11 19 text 0.57267237 tained from the individual studies were subsequently averaged over all three studies 4889 4973 W2920009442.pdf 11 20 separator 0.78170294 ¶ 4973 4975 W2920009442.pdf 11 21 table 0.9828909 "a Restriction index for holding grain yield stable and increasing the protein content b Restriction index for holding protein content stable and increasing the grain yield c Restriction index for holding grain yield stable and increasing the protein yield d Restriction index for holding protein content and increasing the protein yieldProtein yield Indexa GPD Indexb GYD Indexc HP Indexd HY Nitrogen remobilization 0.37 0.19 0.43 0.17 0.43 Nitrogen uptake 0.34 0.43 0.22 0.45 0.23 Protein content 0.27 0.73 0.00 0.72 0.00 Grain yield 0.54 0.00 0.73 0.00 0.72" 4975 5557 W2920009442.pdf 11 0 text 0.9971341 "identifying genes that are speci fically expressed in certain tissues or cell types and, at the same time, regulate the trait according toGWAS ( Slowikowski et al., 2014 ;Calderon et al., 2017 ;Finucane et al., 2018 ;Shang et al., 2020 ). Genotype-Tissue Expression (GTEx) consortium used tissue-speci fic expression quantitative trait loci (eQTL) data instead of using gene expression datadirectly, trying to establish eQTL-based associations betweentissues and traits ( Ongen et al., 2017 )." 0 499 W4221090336.pdf 1 1 separator 0.9865093 ¶ 499 501 W4221090336.pdf 1 2 text 0.99963826 "Regardless of these available methods, this is a typical discovery problem where a yes/no inference needs to be madefor each test. Normally with the same null hypothesis, applyingdifferent methods to the same data produces similar answers asthe statistical power is similar. However, for the tissue-traitassociation problem, the different methods developed aresometimes distinct not only in their setup but also in producing distinct discoveries. For example, Calderon et al. (2017) detected that total cholesterol (TC) was associated with liver ( p=2×1 0 –4), small intestine ( p= 0.01), spleen ( p= 0.04), and adrenal gland ( p= 0.05), supported by, e.g., the nutrient absorption function of the small intestine and the link betweenspleen and lipid metabolism ( Fatouros et al., 1995 ;Ai et al., 2018 )." 501 1321 W4221090336.pdf 1 3 separator 0.983256 ¶ 1321 1323 W4221090336.pdf 1 4 text 0.99969774 "While in Ongen et al. (2017) ’s study, the top 5 enriched tissues for TC were liver ( p= 2.05 × 10 –13), pancreas ( p= 3.83 × 10–13), thyroid ( p= 9.85 × 10–13), uterus ( p= 1.23 × 10–8), and small intestine ( p= 5.59, ×, 10–9). Most tissues ’p-values were lower than 0.05, but the spleen was ranked 19/44 and the adrenal gland 21/44. Their results were quite different from those by Cameron et al. (1974) but claimed to be supported by traditional medical evidence ( Pucci et al., 2000 ) .W h ot ot r u s t ?I n t u i t i v e l yw en o w seem to have more con fidence in the cholesterol-liver and cholesterol-intestine associations. Different assumptions orsetups may capture different biological natures, but it couldalso be limited power that makes their results not agree well.Thus, to see the general picture, we need to systematicallyevaluate the associations between complex traits and tissues,making use of these available distinct methods to gain moreinformation. This requires assessing the operating characteristics of different methods, which is impossible to do conventionally as a gold standard for each tissue-traitassociation is mostly absent." 1323 2506 W4221090336.pdf 1 5 separator 0.9788282 ¶ 2506 2508 W4221090336.pdf 1 6 text 0.9996046 "In fact, for three or more distinct methods testing the same set of null hypotheses, the sensitivity and speci ficity of each method can be estimated without any gold standard ( Pepe and Janes, 2007 ), as long as the methods are conditionally independent (distinct enough, e.g., with distinct assumptions or modelling logic). Thus, based on the estimated operatingcharacteristics, one can combine information captured bydifferent kinds of methods testi ng tissue-trait associations, since none of the methods could capture the full information of the underlying biology." 2508 3092 W4221090336.pdf 1 7 separator 0.98235154 ¶ 3092 3094 W4221090336.pdf 1 8 text 0.9994605 "Here, we aim to integrate the results from different methods to better investigate the tissue-trait association problem. Weapproach this by: 1) applying three distinct methods on thesame set of tissue-trait pairs; 2) conducting maximumlikelihood estimation of the sensitivity and speci ficity of each method in the absence of a gold standard; 3) subsequentlycombining the results from these methods to generate a more credible tissue-trait association atlas." 3094 3558 W4221090336.pdf 1 9 separator 0.9966853 ¶ 3558 3560 W4221090336.pdf 1 10 title 0.9912306 2 MATERIALS AND METHODS 3560 3584 W4221090336.pdf 1 11 separator 0.99601686 ¶ 3584 3586 W4221090336.pdf 1 12 title 0.88544714 "2.1 Estimation of Operating Characteristics and Prevalence" 3586 3647 W4221090336.pdf 1 13 separator 0.9868134 ¶ 3647 3649 W4221090336.pdf 1 14 text 0.9962252 "Let random variable Airepresent the unobservable true association status for the i-th pair of tissue and trait, where Ai = 1 represents associated, and Ai= 0 unassociated. In our model, ρ =P(Ai= 1) is the same for any given i, so without losing generality, we use Ato denote Ai. Given a particular set of significance thresholds for K binary tests of the status of A,w e have Krandom variables Y1,...,YK, for each of i=1 ,...,npairs of tissues and traits. Writing the true- and false-positive rates ofthe K binary tests as φ k=P(Yik=1 |A= 1) and ψk=P(Yik=1 |A= 0), respectively, the unknown parameters are the prevalence of tissue-trait association ρ=P(A= 1) and θ=(φk,ψk),k=1 ,...,K." 3649 4353 W4221090336.pdf 1 15 separator 0.94404644 ¶ 4353 4355 W4221090336.pdf 1 16 text 0.99815565 "With KP3 observed tests, ρand θcan be estimated by maximizing the likelihood function" 4355 4443 W4221090336.pdf 1 17 separator 0.9684973 ¶ 4443 4445 W4221090336.pdf 1 18 math 0.9692596 "Lθ,ρ/parenleftbig/parenrightbig /equals/productdisplayn i/equals1ρPθYi1,...,YiK|A/equals1 () +1−ρ/parenleftbig/parenrightbig /braceleftbig PθYi1,...,YiK|A/equals0 () }.( 1 )" 4445 4623 W4221090336.pdf 1 19 separator 0.96057844 ¶ 4623 4625 W4221090336.pdf 1 20 text 0.9986968 "As the available degrees of freedom, 2K−1, is no less than the number of parameters, 2 K+ 1. Assuming conditional independence of the K binary tests, i.e., given A and theoutcome of any test Y i, one cannot predict the outcomes of the other tests, we have" 4625 4889 W4221090336.pdf 1 21 separator 0.9334161 ¶ 4889 4891 W4221090336.pdf 1 22 math 0.96599627 "Lθ,ρ/parenleftbig/parenrightbig /equals/productdisplayn i/equals1ρ/productdisplayK k/equals1PθYik|A/equals1 () +1−ρ/parenleftbig/parenrightbig /productdisplayK k/equals1PθYik|A/equals0 ()⎧⎨ ⎩⎫⎬ ⎭. (2)" 4891 5104 W4221090336.pdf 1 23 separator 0.988987 ¶ 5104 5106 W4221090336.pdf 1 24 text 0.99931854 "For various p-value thresholds for different tissue-trait association test methods, we used quasi-Newton method foroptimization to solve the above maximum likelihood problem.We bootstrapped the observed binary data to assess the variationof the estimates. In this article, we repeated the bootstrapprocedure for 99 times. Our implementation is publiclyavailable as an R package (see Code Availability ), which can assess three or more methods simultaneously. For the scenario ofthree methods, the maximum likelihood estimates (MLE) of the parameters can be derived analytically ( Pepe and Janes, 2007 ) (see Supplementary Appendix )." 5106 5748 W4221090336.pdf 1 25 separator 0.967137 ¶ 5748 5750 W4221090336.pdf 1 26 text 0.9981333 "For a particular p-value threshold, with the estimated operating characteristics, we used the estimated speci ficityψ k′/equals 1−ψkas weights to highlight the methods with high speci ficity." 5750 5946 W4221090336.pdf 1 27 separator 0.93030024 ¶ 5946 5948 W4221090336.pdf 1 28 text 0.9991179 "We derived a tissue-trait association speci ficity score to evaluate the associations. The score sums up the estimated speci ficity of the methods that gave a positive signal to a particular tissue-traitassociation, divided by the sum of speci ficity across all the methods:" 5948 6226 W4221090336.pdf 1 29 separator 0.97486913 ¶ 6226 6228 W4221090336.pdf 1 30 paratext 0.97217315 Frontiers in Genetics | www.frontiersin.org March 2022 | Volume 13 | Article 798269 2Yang et al. Tissue-Trait Association Identi fication 6228 6365 W4221090336.pdf 1 0 paratext 0.9807855 © 1968 Nature Publishing GroupNATURE, VOL 219, SEPTEMBER 7, 1968 0 64 W2034433882.pdf 2 1 separator 0.9881128 ¶ 65 67 W2034433882.pdf 2 2 text 0.9990181 "while control tubes received either no phytohaemagglutin or phytohaemagglutinin and no lymphocytes. These cultures were incubated at 37° C for 48 h in an atmosphere of 5 per cent 002 and 95 per cent air. The cells and cell debris were then removed by centrifugation at 1,000g for 20 min, and the culture fluid was passed through 'Millipore' filters of pore size 0·45μ. This fluid was placed on fresh individual tube cultures of mouse L cells, Moden bovine kidney (MBK) cells, and human (HeLa) cells, all of which were established 24 h before use at a density of 200,000 cells/tube. After 48 h incubation, these cultures were examined microscopically and cell viability was assayed by their ability to incorporate 140 amino-acids into protein1•2•" 67 852 W2034433882.pdf 2 3 separator 0.9772252 ¶ 853 855 W2034433882.pdf 2 4 text 0.99852216 "Table 1 shows the results obtained with lymphocytes from human peripheral blood, human adenoid tissue, mouse, hamster and cat spleen. It can be seen that phytohaemagglutinin stimulated the release of a toxic factor(s) from the lymphocytes of the various animal species, whereas no toxicity was caused by the medium from control, unstimulated lymphocytes or was caused by phytohaemagglutinin itself. It should be mentioned that of the nine peripheral blood lymphocyte samples which were obtained from different patients, seven responded in the same way as that reported in the table, while the other two demonstrated minimal toxicity." 855 1522 W2034433882.pdf 2 5 separator 0.7591457 ¶ 1523 1525 W2034433882.pdf 2 6 text 0.99946225 "Human adenoid tissues from five different patients were tested and all responded in the manner reported. The data for mouse, hamster and cat spleen tissues are repre­ sentative of many separate experiments." 1525 1740 W2034433882.pdf 2 7 separator 0.77311444 ¶ 1741 1743 W2034433882.pdf 2 8 text 0.99936163 "The specificity of the lymphotoxins obtained from stimulated human and mouse lymphocytes was tested next. The experimental methods were as before, except that the medium was tested simultaneously on three cell lines: MBK, L, and HeLa. The results of these experi­ ments (Table 2) show that all the cell lines were sus-" 1743 2076 W2034433882.pdf 2 9 separator 0.9943932 ¶ 2076 2078 W2034433882.pdf 2 10 title 0.7934891 Table ]. CYTOTOXIC EFFECT OF LYMPHOTOXINS FROM VARIOUS ANIMAL 2078 2140 W2034433882.pdf 2 11 table 0.98821557 "¶ SPECIES Ol'I MOUSE L CELLS Phyto- Counts per min incorporated Source of lymphocytes haemagglutinin into L cell protein Human peripheral blood Lymphs + 5,640 Lymphs 21,328 None + 19,980 Human adenoid tissue Patient A Lymphs + 7,173 Lymphs 19,275 Patient B Lymphs + 7,158 Lymphs 20,025 None + 19,317 Mouse spleen Lymphs + 1,082 Lymphs 19,74~ None + 17,941 Cat spleen Lymphs + 5,025 Lymphs 19,913 None + 21,105 Hamster spleen Lymphs + 6,496 Lymphs 21,777 None + 20,978" 2141 2687 W2034433882.pdf 2 12 separator 0.94056976 ¶ 2688 2690 W2034433882.pdf 2 13 text 0.9965587 "After 48 h incubation in the presence of the lymphotoxin medium, the cells were pulse labelled for 15 min with 2·0 ml. of a ""C amino-acid hvdrolysate, 0·30μCi/ml." 2690 2856 W2034433882.pdf 2 14 separator 0.65457857 2856 2857 W2034433882.pdf 2 15 text 0.9085269 . 2857 2858 W2034433882.pdf 2 16 separator 0.99676865 ¶ 2859 2861 W2034433882.pdf 2 17 title 0.9353638 "Table 2. CYTOTOXIC EFFECT OF HUMAN AND MOUSE LYMPHOTOXIN ON SEVERAL MAMMALIAN CELL LINES" 2861 2953 W2034433882.pdf 2 18 table 0.99463904 "¶ C.p.m. incorporated into cellular protein Source of lymphocytes--------+ Human peri­ pheral blood Cell line L cell MBK HeLa Mouse spleen Lymphs +PHA 907 2,001 L:ymphs -PHA 8,497 7,543 None +PHA 8,141 7,601 Lymphs +PHA 2,325 2,136 Lymphs -PHA None +PHA 6,471 4,206 6,082 4,012 Lymphs + PHA 1,487 2,541 Lymphs -PHA 9,743 9,243 None +PHA 9,884 9,091" 2954 3353 W2034433882.pdf 2 19 separator 0.95215917 ¶ 3354 3356 W2034433882.pdf 2 20 text 0.99410105 "After 48 h incubation in the presence of lymphotoxin medium, the cells were pulae labelled for 8 min with 2·0 ml. of a ""C amino-acid hydrolysate, 0·30 μCi/ml. 1077 ceptible to the toxic action. Lymphocytes from several different mammalian species appear to release lympho­ toxin-like materials when stimulated with phytohaem­ agglutinin, and these materials can act in various types of cells. Some of the chemical characteristics of mouse lymphotoxin have been described3 and we are investi­ gating the similarities and immunological distinctions between mouse and human lymphotoxin (unpublished results of Granger, Kolb and Williams)." 3356 4022 W2034433882.pdf 2 21 separator 0.97782964 ¶ 4023 4025 W2034433882.pdf 2 22 text 0.9500409 "G. G. was supported by a grant from the US National Institutes of Health and a grant from the Cancer Research Coordinating Committee of the University of California. " 4025 4199 W2034433882.pdf 2 23 separator 0.5077777 ¶ 4199 4200 W2034433882.pdf 2 24 text 0.96264684 "T. W. was supported by a grant from the National Institutes of Health, US Public Health Service." 4200 4300 W2034433882.pdf 2 25 separator 0.979244 ¶ 4301 4303 W2034433882.pdf 2 26 contact 0.9894789 "TERRY W. WILLIAMS GALE A. GRANGER Department of Molecular and Cell Biology, University of California, Irvine, California." 4303 4437 W2034433882.pdf 2 27 separator 0.8706293 ¶ 4438 4440 W2034433882.pdf 2 28 paratext 0.8182382 Received June 11; revised July 9, 1968. 4440 4480 W2034433882.pdf 2 29 separator 0.9935078 ¶ 4481 4483 W2034433882.pdf 2 30 bibliography 0.9943262 "1 Granger, G. A., and Williams, T. W., Nature, 218, 1253 (1968). • Granger, G. A., and Kolb, W. P., J. Immunol., 101, 11111968). 'Kolb, W. P., and Granger, G. A., Fed. Proc., 27, 687 (1968)." 4483 4680 W2034433882.pdf 2 31 separator 0.99123675 ¶ 4681 4683 W2034433882.pdf 2 32 title 0.9920825 "Relationship between Cell Size and Time of Initiation of DNA Replication" 4683 4759 W2034433882.pdf 2 33 separator 0.99513626 ¶ 4760 4762 W2034433882.pdf 2 34 text 0.9994935 "RouNDS of DNA replication are initiated in Escherichia coli at different stages in the cell cycle of bacteria growing at different rates1• It is possible to calculate that the initiation of a round of DNA replication always takes place at a time when the cell mass/chromosome origin reaches a particular critical value. In other words, the mass at which initiation takes place is always an integral multiple of a particular mass. This constancy in turn provides an explanation for the increase in size of cells with increase in the rate of growth." 4762 5337 W2034433882.pdf 2 35 separator 0.9686918 ¶ 5338 5340 W2034433882.pdf 2 36 text 0.9995972 "Schaechter, Maaloe and Kjeldgaard2 showed that the size of cells of Salmonella typhimurium depended on the medium in which they were growing. The size of cells increases exponentially with the rate of growth in popula­ tions growing in different media. Thus log (cell mass)= k (growth rate)." 5340 5646 W2034433882.pdf 2 37 separator 0.9337396 ¶ 5647 5649 W2034433882.pdf 2 38 text 0.99967617 "Cooper and Helmstetter1 have used synchronous populations of Escherichia coli B/r to show that the time of initiation of rounds of DNA synthesis relative to cell division varied with the growth rate of the cells. The time of initiation of DNA replication could be predicted very precisely by assuming that there was a constant interval of time between the initiation of a round of DNA replication and a subsequent division of the cell. In their experiments this time interval was close to 60 min for growth rates between one and three doublings/h. Because the time taken to replicate one chromosome was constant (40 min) at all rates of growth, rounds of DNA replication overlapped in cells growing with a generation time of less than 40 min. Thus in fast growing cells a new round of replication begins before the previous one has finished. In slowly growing cells with generation times greater than 40 min, there is a gap between the end of a round of replication and cell division." 5649 6685 W2034433882.pdf 2 39 separator 0.8079883 ¶ 6686 6688 W2034433882.pdf 2 40 text 0.99944514 "These empirical rules are based on the observation that the time of initiation of DNA replication varies relative to the previous division of cells growing at different rates." 6688 6870 W2034433882.pdf 2 41 separator 0.76597655 ¶ 6871 6873 W2034433882.pdf 2 42 text 0.9995662 "No explanation was suggested as to why replication of DNA was initiated at a particular time. A combination of these observations with those of Schaechter et al., on the average size of cells growing at different rates, how­ ever, reveals a remarkable constancy of cell mass at the time of initiation of replication. This is shown graphically in Fig. 1. This constancy in turn suggests possible mech­ anisms whereby the time of DNA initiation is determined." 6873 7350 W2034433882.pdf 2 0 title 0.98162955 "3.2.3 Using an appropriately designed well-being impact assessment framework to incorporate values into organisational processes, systems(including data), products and services requirements management systems" 0 212 W3208936200.pdf 9 1 separator 0.9886502 ¶ 212 214 W3208936200.pdf 9 2 text 0.99960846 "The proposed framework defines well-being as the continuous and sustainable physical, mental, and social flourishing of individuals, communities and populations where their economic needs are cared for within a thriving ecological environment. Through an iterative well-being impact assessment (WIA) process during conceptualization, analysis, design, development, and throughout the life span of a system, product or service the method establishes values of various stakeholders including creators/developers and uses the assessment findings to develop and improve a product, service or system of interest. It makes use of known knowledge bases or databases of values and the indicators of how those values can be impacted by the proposed system, service or product. New values and indicators can be identified during well-being impact assessment processes and these new findings are added to the database thereby continuously improving its content." 214 1187 W3208936200.pdf 9 3 separator 0.9665965 ¶ 1187 1189 W3208936200.pdf 9 4 text 0.9991861 "The Well-being Impact Assessment framework can be applied to any process and at any stage or phase in the life cycle of a system, product or service. However, in the case of systems, services and products it is strongly recommended that it be applied right from the beginning or start - at ideation, right through specification, development, testing, implementation, use, management and decommissioning. In this context, the use of the Well-being Impact Assessment Framework may be illustrated as follows:" 1189 1705 W3208936200.pdf 9 5 separator 0.74148715 1705 1706 W3208936200.pdf 9 6 text 0.99484664 "¶ •At the Governance and Executive Levels the WIA framework helps to initiate discussions by providing knowledge (to initiate, drive and guide discussions) from the information derived from reference databases (e.g. OECD) •During ideation, the impact assessment process can initiate the requirements discovery and in this way makes contributions to comprehensive innovation management and ideation processes •During system, product or service requirements elicitation and specification processes, it widens scope and coverage encouraging participation and contributions from all stakeholders •During development, it opens up for a continuous engagement process between system/product/service creators or developers and all stakeholders. Values and related requirements are continuously reviewed and refined, and used to comprehensively define sprints in development •During testing the framework is an enabler for collaborative and all-inclusive testing processes •During live use and operation, the framework further opens up for collaborative and all inclusive system/product/service improvement processes. It strengthens and puts transparency into failure management processes •At the decommissioning or retirement phase, the framework opens up for detailed engagements on user(all levels) experiences and performance levels achieved" 1706 3086 W3208936200.pdf 9 7 separator 0.99498224 ¶ 3086 3088 W3208936200.pdf 9 8 paratext 0.69618374 9How Factoring Ethi 3088 3108 W3208936200.pdf 9 9 title 0.64315695 cs Encourages and Stimulates Innovative Development of 3108 3162 W3208936200.pdf 9 10 paratext 0.6917451 IT Systems ... 3162 3175 W3208936200.pdf 9 11 separator 0.5012245 3175 3176 W3208936200.pdf 9 12 paratext 0.95842636 ¶ DOI: http:/ /dx.doi.org/10.5772/intechopen.9 7556 3176 3227 W3208936200.pdf 9 0 paratext 0.8087226 "Review of: ""Intelligent Transportation System Real-Time Tracking""" 0 67 W4384928849.pdf 0 1 separator 0.8920482 ¶ 67 69 W4384928849.pdf 0 2 contact 0.74312544 Abdul Samad Shibghatullah 69 95 W4384928849.pdf 0 3 paratext 0.46872136 ¶ 1 95 99 W4384928849.pdf 0 4 contact 0.36917642 99 100 W4384928849.pdf 0 5 paratext 0.48020858 ¶ 1 100 103 W4384928849.pdf 0 6 contact 0.58112174 ¶ UCSI University 103 122 W4384928849.pdf 0 7 separator 0.991439 ¶ 122 124 W4384928849.pdf 0 8 title 0.8513851 Potential competing interests: 124 155 W4384928849.pdf 0 9 separator 0.960027 ¶ 155 157 W4384928849.pdf 0 10 text 0.99098074 No potential competing interests to declare. 158 203 W4384928849.pdf 0 11 separator 0.5715551 ¶ 203 205 W4384928849.pdf 0 12 text 0.9977636 "The research paper presented the implementation of an intelligent transportation system (ITS) using GPS technology, mobile applications development, and server infrastructure. The results show a very good results. However, there is no comparison or analysis on the current or existing system which similar. It is good if the authors can add the comparison in this paper." 205 583 W4384928849.pdf 0 13 separator 0.960806 ¶ 583 585 W4384928849.pdf 0 14 paratext 0.9769075 "Qeios, CC-BY 4.0 · Review, July 20, 2023" 585 633 W4384928849.pdf 0 15 separator 0.54522634 633 634 W4384928849.pdf 0 16 paratext 0.94915307 "¶ Qeios ID: V1Y9PJ · https://doi.org/10.32388/V1Y9PJ 1 /" 634 698 W4384928849.pdf 0 17 separator 0.7914595 ¶ 1 698 702 W4384928849.pdf 0 0 paratext 0.99027056 Materials 2023 ,16, 2344 5 of 10 0 32 W4324380626.pdf 4 1 separator 0.9732499 ¶ 32 34 W4324380626.pdf 4 2 text 0.9724166 "emission with respect to the free space case, while a value grater than one corresponds to an increment." 34 141 W4324380626.pdf 4 3 separator 0.99039966 ¶ 141 143 W4324380626.pdf 4 4 caption 0.9929845 "Figure 2. (a) Layout of the device simulated with FDTD. In red, the optically active part of the device is represented. This is simulated as a 1 μm1μm undoped silicon square with dipole sources in it. The silicon oxide layer is the grey box and the contacts (in blue) are modelled as doped silicon regions. The blue arrow indicates the orientation of the dipole source whereas the grey concentric lines are the dipole radiation pattern. ( b) Modification of the Purcell factor considering a variation of the lateral size of the optically active area." 143 704 W4324380626.pdf 4 5 separator 0.993006 ¶ 704 706 W4324380626.pdf 4 6 text 0.9996479 "We have found that the percentage of radiation emitted upward remains stable around a value of 6%, regardless of the sample size. The two smaller geometries, which have a Purcell factor of 0.41 and 0.72, respectively, do not promote any increase of spontaneous dipole emission, as they are not resonant with the emitted wavelength. The largest has a Purcell factor of 1.16, still far from optimal resonant conditions." 706 1132 W4324380626.pdf 4 7 separator 0.957772 ¶ 1132 1134 W4324380626.pdf 4 8 text 0.99954647 "A parametric study is conducted for the smallest of the fabricated structures, to check the tolerance in the case the fabrication deviates from the nominal size. For the smaller sample, the length of the cuboid is modified, considering a nominal length of 1000 nm and assuming a possible error up to 5%. The evaluated range is therefore from 950 nm to 1050 nm, with a step size of 5 nm. As shown in Figure 2b, the Purcell Factor varies smoothly from 0.46 to 0.38 with no resonances. This suggests that in case of possible small size deviations, the diode will continue to behave according to expectations." 1134 1752 W4324380626.pdf 4 9 separator 0.99691033 ¶ 1752 1754 W4324380626.pdf 4 10 title 0.99130285 4. Experimental Results 1754 1778 W4324380626.pdf 4 11 separator 0.9969232 ¶ 1778 1780 W4324380626.pdf 4 12 text 0.9981028 "We will now discuss the experimental results based on the fabricated devices. First, we will provide the experimental characterization of the effectiveness of the oxygen doping. Next, we will move to the electroluminescence observed in the devices." 1780 2033 W4324380626.pdf 4 13 separator 0.9972453 ¶ 2033 2035 W4324380626.pdf 4 14 title 0.9927119 4.1. Characterization of Oxygen Doping 2035 2074 W4324380626.pdf 4 15 separator 0.9951779 ¶ 2074 2076 W4324380626.pdf 4 16 text 0.9946397 "In order to understand the best oxygen co-doping dose, three non-fabricated 220 nm SOI samples are doped with erbium and oxygen and then characterized by PL spectroscopy. The erbium doping and oxygen implantation are performed in the same conditions applied to the devices described in the previous section, namely using an energy equal to 300 keV and a dose of 11013Er cm" 2076 2458 W4324380626.pdf 4 0 paratext 0.9888162 Page 2 of 13 Su et al. BMC Plant Biology (2022) 22:224 0 63 W4225278766.pdf 1 1 separator 0.9910244 ¶ 64 66 W4225278766.pdf 1 2 text 0.9995106 "all downstream flavonoids, and generally be classified as early biosynthesis genes (EBGs). While late biosynthesis genes (LBGs) are specifically required for the biosynthe - sis of anthocyanins, such as dihydroflavonol 4-reductase (DFR), anthocyanidin synthase (ANS ), leucoanthocya - nidin dioxygenase (LDOX ) and UDPglucose:flavonoid- 3-O- glucosyltransferase (UF3GT) [11]. The expressions of these anthocyanin structural genes are conservatively controlled by the MYB-bHLH-WDR (MBW) transcrip - tion factor complex [12, 13]. Two R2R3-MYB genes, Production of anthocyanin pigment1 (PAP1/MYB75, At1g56650) and PAP2 (MYB90, At1g66390), has been identified in Arabidopsis as positive regulators for the expression of anthocyanin biosynthesis genes [14–16]." 66 858 W4225278766.pdf 1 3 separator 0.53890544 ¶ 859 861 W4225278766.pdf 1 4 text 0.9993717 "The PAP1 homologs in snapdragon, radish and cotton have also been revealed stimulating anthocyanin produc - tion [17–19]." 861 989 W4225278766.pdf 1 5 separator 0.92620456 ¶ 989 991 W4225278766.pdf 1 6 text 0.9995905 "Previous study in our group has revealed 0.5 mM sodium nitroprusside (SNP , a NO-releasing compound) application significant increased anthocyanin accumula - tion in radish sprout, along with enhanced endogenous NO levels [18]. Interestingly, an opposite phenotype has been reported in Lycium fruits during ripening, as the SNP supply and endogenous NO content negatively correlated with anthocyanin biosynthesis [20]. To fur - ther clarify the role of NO in anthocyanin production, we used hemin treatment in this study to induce the endogenous NO content. The effectiveness of hemin in trigger endogenous NO levels has been evidenced previ - ously in cucumber and tomato lateral roots [21, 22]. As a heme oxygenase-1 (HO-1) inducer, hemin application could improves plant stress tolerance in different plant species under various abiotic stress conditions [23–25]." 991 1901 W4225278766.pdf 1 7 separator 0.7780297 ¶ 1902 1904 W4225278766.pdf 1 8 text 0.99956083 "Thus, hemin treatment has the potential to benefit plant growth, rather than to generate stress induced anthocya - nin production." 1904 2040 W4225278766.pdf 1 9 separator 0.93359214 ¶ 2040 2042 W4225278766.pdf 1 10 text 0.99969584 "We used cherry radish in the present study, as it is a nutritious and popular vegetable worldwide [26]. Moreo - ver, with the red hypocotyls resulting from anthocyanin accumulation, radish sprouts could provide visual evi - dence for the biosynthesis of anthocyanins. Our results here suggested hemin could induce anthocyanin accu - mulation in plants through NO signalling pathway." 2042 2440 W4225278766.pdf 1 11 separator 0.9952707 ¶ 2440 2442 W4225278766.pdf 1 12 title 0.93723315 Results 2442 2450 W4225278766.pdf 1 13 separator 0.962976 ¶ 2450 2452 W4225278766.pdf 1 14 title 0.93411475 "Effects of hemin application on anthocyanin accumulation and endogenous NO production in radish sprouts" 2452 2559 W4225278766.pdf 1 15 separator 0.98794675 ¶ 2559 2561 W4225278766.pdf 1 16 text 0.9997414 "The anthocyanin contents in the hypocotyls of radish sprouts were examined after cultured with 1, 10, 25 and 50 μM hemin for 48 h. As shown in Fig. 1, signifi - cantly higher anthocyanin contents were observed in all hemin treated hypocotyls, along with enhanced NO levels, as compare to no-hemin control. However, the increase of anthocyanin was disproportionate to the raise of NO amount. Clearly, the anthocyanin biosyn - thesis in radish hypocotyl was highly sensitive to low level of hemin application, but quickly plateaued out when supplied with higher concentrations of hemin concentrations (Fig. 1B). In contrast, the endogenous NO contents exhibited a roughly linear increase by hemin applications up to 25 μM (Fig. 1C). The appli - cation of 50 μM hemin increased radish total fresh weight, shoot fresh weight and hypocotyl fresh weight (Fig. 1 D-F)." 2561 3470 W4225278766.pdf 1 17 separator 0.97802734 ¶ 3470 3472 W4225278766.pdf 1 18 text 0.9972554 "The effects of hemin treatment on the contents of dif - ferent anthocyanin monomers were also assessed using liquid chromatography–mass spectrometry (LC–MS)." 3472 3635 W4225278766.pdf 1 19 separator 0.9687327 ¶ 3636 3638 W4225278766.pdf 1 20 text 0.99957716 "Among the different anthocyanin monomers, cyanidin 3-O-glucosyl-rutinoside was the main component in rad - ish hypocotyls, which accounted for 64.4% of the total anthocyanin, followed by cyanidin 3-O-xylosyl-rutino - side (11.2%), pelargonidin 3-O-glucosyl-glucoside (7.4%), peonidin 3-O-coumaroylglucoside-5-O-glucoside (5.4%) and pelargonidin 3-O-glucosyl-rutinoside (3.6%), and others only made up to less than 8% of the total anthocy - anin contents (Fig. 2). 10 μM hemin treatment exhibited a ~ 30% higher total anthocyanin level, mainly attributed to the 19.1%, 87.4%, 21.5% and 132.8% increases of cya - nidin 3-O-glucosyl-rutinoside, pelargonidin 3-O-glu - cosyl-glucoside, pelargonidin 3-O-glucosyl-rutinoside and petunidin 3-O-rutinoside respectively (Fig. 2). In contrast, the amounts of cyanidin 3-O-sophoroside, pel - argonidin 3-O-galactoside, cyanidin 3-O-(6’’-caffeoyl- glucoside) were significantly reduced in hemin cultured radish hypocotyls (Fig. 2). The adjusted monomer pro - portions probably led to the slight colour changes of the hypocotyl cross sections shown in Fig. 1A." 3638 4788 W4225278766.pdf 1 21 separator 0.9953937 ¶ 4788 4790 W4225278766.pdf 1 22 title 0.98402786 "Effects of NO on anthocyanin contents in hypocotyls of radish sprouts" 4790 4863 W4225278766.pdf 1 23 separator 0.99168 ¶ 4863 4865 W4225278766.pdf 1 24 text 0.99954534 "To further investigate the effect of NO on anthocyanin accumulation in the radish hypocotyls, Sodium Nitro - prusside (SNP , an exogenous NO donor) and carboxy- PTIO (cPTIO, a specific NO-scavenger) were then used." 4865 5087 W4225278766.pdf 1 25 separator 0.89740324 ¶ 5088 5090 W4225278766.pdf 1 26 text 0.9992618 "As shown in Fig. 3A, 10, 50, 100, 200 and 1000 μM SNP applications significantly enhanced anthocyanin con - tents, with the highest amount achieved by 200 μM SNP treatment. On the other hand, 50, 100, 200 and 1000 μM cPTIO treatments significantly decreased anthocyanin contents in radish hypocotyls, with the lowest anthocya - nin level detected by 200 μM cPTIO treatment (Fig. 3B)." 5090 5492 W4225278766.pdf 1 27 separator 0.9632319 ¶ 5493 5495 W4225278766.pdf 1 28 text 0.9995815 "Taken together, anthocyanin accumulation in hypoco - tyls positively correlated with NO production at low to medium levels, whereas high level NO exposure could suppress anthocyanin accumulation." 5495 5699 W4225278766.pdf 1 0 paratext 0.9780713 "1 SCIeNTIfIC REPoRTS | (2018) 8:2171 | DOI:10.1038/s41598-018-20622-8www.nature.com/scientificreports" 0 107 W4247285079.pdf 0 1 title 0.9831438 "Contraction of T cell richness in lung cancer brain metastases" 107 172 W4247285079.pdf 0 2 separator 0.9949025 ¶ 172 174 W4247285079.pdf 0 3 table 0.49711454 174 175 W4247285079.pdf 0 4 contact 0.38901258 Aaron S 175 182 W4247285079.pdf 0 5 table 0.42883387 . 182 183 W4247285079.pdf 0 6 contact 0.4294888 Mans 183 188 W4247285079.pdf 0 7 table 0.39321366 field 1, Hong 188 203 W4247285079.pdf 0 8 contact 0.38284677 zheng 203 208 W4247285079.pdf 0 9 table 0.5042484 "Ren2, Shari Sutor3, Vivekananda Sarangi4, Asha Nair4, Jaime Davila 4, Laura R. Elsbernd3, Julia B. Udell5, Roxana S. Dronca1, Sean Park 6, Svetomir N. Markovic1, Zhi" 208 384 W4247285079.pdf 0 10 contact 0.4115082 fu 384 386 W4247285079.pdf 0 11 table 0.5464689 "Sun 4, Kevin C. Halling2, Wendy K. Nevala3, Marie Christine Aubry2, Hai" 386 462 W4247285079.pdf 0 12 contact 0.3695463 dong 462 466 W4247285079.pdf 0 13 table 0.40893745 Dong 3 & Jin Jen2,7 466 488 W4247285079.pdf 0 14 separator 0.99502206 ¶ 488 490 W4247285079.pdf 0 15 text 0.99948764 "Very little is known about how the adaptive immune system responds to clonal evolution and tumor heterogeneity in non-small cell lung cancer. We profiled the T-cell receptor β complementarity determining region 3 in 20 patients with fully resected non-small cell lung cancer primary lesions and paired brain metastases. We characterized the richness, abundance and overlap of T cell clones between pairs, in addition to the tumor mutation burden and predicted neoantigens. We found a significant contraction in the number of unique T cell clones in brain metastases compared to paired primary cancers. The vast majority of T cell clones were specific to a single lesion, and there was minimal overlap in T cell clones between paired lesions. Despite the contraction in the number of T cell clones, brain metastases had higher non-synonymous mutation burdens than primary lesions. Our results suggest that there is greater richness of T cell clones in primary lung cancers than their paired metastases despite the higher mutation burden observed in metastatic lesions. These results may have implications for immunotherapy." 490 1631 W4247285079.pdf 0 16 separator 0.99160624 ¶ 1631 1633 W4247285079.pdf 0 17 text 0.99856985 "Advances in genomic profiling have facilitated the molecular characterization of tumor heterogeneity in many types of cancers. Although the implications of spatial and temporal tumor heterogeneity may not yet be fully understood, clonal evolution likely affects prognosis, treatment selection, therapeutic response and treatment resistance 1–3. Despite our burgeoning understanding of tumor heterogeneity, very little is known about the dynamics of tumor immunogenicity and the repertoire of the adaptive immune response to metastatic non-small cell lung cancer (NSCLC)." 1633 2215 W4247285079.pdf 0 18 separator 0.9800792 ¶ 2215 2217 W4247285079.pdf 0 19 text 0.99755096 "The discovery of programmed cell death 1 ligand 1 (PD-L1) 4 and its effects on T cell function and survival5 have revolutionized cancer therapeutics. There are three drugs that inhibit PD-L1 or its receptor PD-1 that are approved by the FDA for the treatment of metastatic NSCLC 6 and many others agents are in development. PD-L1 expression by tumor cells has been explored as a predictive biomarker for patients to receive these agents, but there is significant confusion about the clinical applicability of discrepant PD-L1 expression between paired lesions 7. Many issues including the dynamics and context of PD-L1 expression8, the size of a specimen9, the timing of specimen acquisition in relation to treatment, and the agreement between assays all contribute to this confusion 10,11. Additionally, we have reported that PD-L1 expression can be temporally dynamic12 and is heter - ogeneous between multifocal lung cancers13 and between paired primary lesions and brain metastases14. During these studies we noticed that there was significant variability in tumor infiltration by lymphocytes between paired primary lesions and brain metastases. Accordingly, we sought to assess the distribution of T cell clones between paired NSCLC primary lesions and brain metastases in order to characterize the temporal and spatial relatedness of the adaptive immune response." 2217 3609 W4247285079.pdf 0 20 separator 0.99507403 ¶ 3609 3611 W4247285079.pdf 0 21 title 0.9236709 Results 3611 3619 W4247285079.pdf 0 22 separator 0.9963607 ¶ 3619 3621 W4247285079.pdf 0 23 text 0.9995612 "Brain metastases have significantly fewer T cell clones than paired primary lesions. To eval- uate the distribution of T cell clones between primary and metastatic sites, we identified a cohort of 20 patients" 3621 3832 W4247285079.pdf 0 24 separator 0.9939257 ¶ 3833 3835 W4247285079.pdf 0 25 contact 0.9821906 "1Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA. 2Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. 3Department of Immunology, Mayo Clinic, Rochester, MN, USA. 4Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. 5Center for International Blood and Marrow Transplant Research, Minneapolis, MN, USA. 6Department of Radiation Oncology, Mayo Clinic, Rochester, MN, USA. 7Genome Analysis Core and the Biomarker Discovery Program, Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. Correspondence and requests for materials should be addressed to A.S.M. (email: mansfield.aaron@mayo.edu ) or J.J. (email: Jen.Jin@mayo.edu )" 3835 4558 W4247285079.pdf 0 26 paratext 0.90640473 "Received: 7 November 2017 Accepted: 17 January 2018 Published: xx xx xxxxOPEN" 4558 4639 W4247285079.pdf 0 27 separator 0.99612194 ¶ 4639 4641 W4247285079.pdf 0 0 paratext 0.9844322 New J. Phys. 18(2016 )043019 doi:10.1088 /1367-2630 /18/4/043019 0 64 W3100348251.pdf 1 1 separator 0.9252274 ¶ 64 66 W3100348251.pdf 1 2 title 0.9002979 PAPER 66 72 W3100348251.pdf 1 3 separator 0.8514668 ¶ 72 74 W3100348251.pdf 1 4 title 0.9864428 Cyclic transformation of orbital angular momentum modes 74 130 W3100348251.pdf 1 5 separator 0.98793566 ¶ 130 132 W3100348251.pdf 1 6 contact 0.9786528 Florian Schlederer1,2, Mario Krenn1,2,4, Robert Fickler1,2,3, Mehul Malik1,2and Anton Zeilinger1,2,4 132 233 W3100348251.pdf 1 7 separator 0.5552852 ¶ 233 235 W3100348251.pdf 1 8 contact 0.98709404 "1Institute for Quantum Optics and Quantum Information, Boltzmanngasse 3, A-1090 Wien, Austria 2Vienna Center for Quantum Science and Technology (VCQ ), Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria" 235 474 W3100348251.pdf 1 9 separator 0.5379726 474 475 W3100348251.pdf 1 10 contact 0.9770437 "¶ 3Present address : Department of Physics and Max Planck Centre for Extreme and Quantum Photonics, University of Ottawa,Ottawa, K1N 6N5, Canada" 475 621 W3100348251.pdf 1 11 separator 0.8728866 ¶ 621 623 W3100348251.pdf 1 12 contact 0.9897266 "4Authors to whom any correspondence should be addressed. E-mail: mario.krenn@univie.ac.at andanton.zeilinger@univie.ac.at" 623 747 W3100348251.pdf 1 13 separator 0.9877231 ¶ 747 749 W3100348251.pdf 1 14 paratext 0.42531228 Keywords: 749 759 W3100348251.pdf 1 15 text 0.44940448 photonic orbital angular momentum, quantum transformation, computer-designed experiment, high-dimensional Hilbert- 759 874 W3100348251.pdf 1 16 paratext 0.36671773 ¶ 874 876 W3100348251.pdf 1 17 text 0.36869052 space 876 882 W3100348251.pdf 1 18 paratext 0.3917321 , 882 883 W3100348251.pdf 1 19 text 0.40955225 cyclic 883 890 W3100348251.pdf 1 20 paratext 0.39249757 transformation 890 905 W3100348251.pdf 1 21 separator 0.9961939 ¶ 905 907 W3100348251.pdf 1 22 title 0.9579758 Abstract 907 916 W3100348251.pdf 1 23 separator 0.99377394 ¶ 916 918 W3100348251.pdf 1 24 text 0.9996625 "The spatial modes of photons are one realization o f a QuDit, a quantum system that is described in aD-dimensional Hilbert space. In order to perform quantum information tasks with QuDits, a general class of D-dimensional unitary transfo rmations is needed. Among these, cyclic transforma- tions are an important special case required in many high-dimensional quantum communication protocols. In this paper, we experimentally demonstrate a cyclic transformation in the high-dimensional space of photonic orbital angular momentum (OAM ). Using simple linear optical components, we show a successful four-fold cycli c transformation of OAM modes. Interestingly, our experimental setup was found by a computer algorithm. In addition to the four-cyclic transformation, the algorithm also found extensi ons to higher-dimensional cycles in a hybrid space of OAM and polarization. Besides being useful for quantum cryptography with QuDits, cyclictransformations are key for the experimental production of high-dimensional maximally entangledBell-states." 918 1981 W3100348251.pdf 1 25 separator 0.9973401 ¶ 1981 1983 W3100348251.pdf 1 26 title 0.92115676 Introduction 1983 1996 W3100348251.pdf 1 27 separator 0.9949789 ¶ 1996 1998 W3100348251.pdf 1 28 text 0.99977106 "The polarization of photons is a well-studied and reliable degree-of-freedom for the transmission of information. Using simple optical components such as half and quarter wave-plates, one can perform anyunitary operation for polarization. However, photon polarization resides in a two-dimensional space, where themaximal information content of a single photon is limited to one bit. Having access to more than one bit perphoton is not only conceptually interesting, but allows the implementation of novel advanced quantum communication and computation problems [1,2]. For example, moving to a larger alphabet in quantum key distribution not only increases the key generation rate, but also provides improved resistance against noise andadvanced eavesdropping attacks [3–5]." 1998 2778 W3100348251.pdf 1 29 separator 0.9489862 ¶ 2778 2780 W3100348251.pdf 1 30 text 0.9996435 "There are several options for exploring discrete high-dimensional photonic degrees-of-freedom. For example, one can send a photon into one out of many possible paths [6,7]. In such a ‘path-encoding, ’it is also known how to perform arbitrary unitary transformations [8]. However, path-encoding is not well suited for the purpose of communication due to very strict alignment and stability requirements. A more suitable degree-of-freedom is the spatial structure of photons, which involves Hermite –Gauss [9], Ince –Gauss [10,11]or Laguerre – Gauss modes [12,13]in the paraxial approximation. In particular, photons with a Laguerre –Gaussian mode structure can carry integer values lof orbital angular momentum (OAM )with a helical phase front which goes from 0 to pl2. As the OAM is theoretically unbounded, it gives access to a large state space. For this reason, it has been used in many classical [14–16]and quantum communication experiments [17–19], as well as in the investigation of quantum entanglement in large Hilbert spaces [20–22]." 2780 3841 W3100348251.pdf 1 31 separator 0.87218785 ¶ 3841 3843 W3100348251.pdf 1 32 text 0.99919474 "The ability to perform arbitrary unitary transformations directly in the OAM degree-of-freedom would greatly expand its use in quantum information. An indirect approach to carrying out such transformations is to" 3843 4057 W3100348251.pdf 1 33 separator 0.75693977 ¶ 4057 4059 W3100348251.pdf 1 34 paratext 0.8804064 "OPEN ACCESS RECEIVED 14 December 2015 REVISED 3 March 2016 ACCEPTED FOR PUBLICATION 24 March 2016 PUBLISHED 14 April 2016" 4059 4197 W3100348251.pdf 1 35 separator 0.7977272 ¶ 4197 4199 W3100348251.pdf 1 36 paratext 0.9285497 "Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence . Any further distribution of this work must maintain attribution to the author (s)and the title of the work, journal citation and DOI." 4199 4463 W3100348251.pdf 1 37 separator 0.7087041 ¶ 4463 4465 W3100348251.pdf 1 38 paratext 0.9589065 © 2016 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft 4465 4531 W3100348251.pdf 1 0 text 0.99796814 "observed and classified into three groups: Around type (type A), Cobweb type (type C) and Deficient type (type D) as shown in Figs. 3,4and 5." 0 145 W2955711888.pdf 4 1 separator 0.98017395 ¶ 145 147 W2955711888.pdf 4 2 text 0.9994859 "The distribution of blood flow patterns between affected status and the position of the colon were com- pared. Three sampling types of vascular distribution at the same segment may be inconsistent (for example, two As and one C), and the more serious type determined the data of this segment (type C). Most patients did not have type D and no corresponding proportion was given at this time (NA). The difference of blood flow pattern distribution was obvious between UC patients andhealthy subjects ( P<0.01). Further comparison showed that the difference of the blood flow distribution of UC patients and healthy subjects in the ascending and trans- verse/descending colon was also significantly different (P<0.05 and P<0.01, respectively)." 147 913 W2955711888.pdf 4 3 separator 0.9740092 ¶ 913 915 W2955711888.pdf 4 4 text 0.99939215 "Type A blood flow was the most common type of capillary distribution for healthy subjects and accounted for 66.67% of the data. Type C blood flow could be seen in healthy subjects and UC patients. Type D blood flow only appeared in UC patients of Mayo score 1 as shown in Table 4." 915 1206 W2955711888.pdf 4 5 separator 0.996783 ¶ 1206 1208 W2955711888.pdf 4 6 title 0.99358344 Patients ’records review and recurrence 1208 1248 W2955711888.pdf 4 7 separator 0.9944117 ¶ 1248 1250 W2955711888.pdf 4 8 text 0.9954353 "Over nearly 5 years, all of the patients had clinical re- lapse and the minimum was at least one time, while the maximum was 4 times of moderate or severe clinical re- currence. There were moderate to more severe relapses in three patients with type D blood flow within 1 year. Among the three patients with type D blood flow, there were two patients that received a step-up treatment scheme as shown in Table 5." 1250 1677 W2955711888.pdf 4 9 separator 0.9972266 ¶ 1677 1679 W2955711888.pdf 4 10 title 0.98961484 Discussion 1679 1690 W2955711888.pdf 4 11 separator 0.99503624 ¶ 1690 1692 W2955711888.pdf 4 12 text 0.9996674 "The most interesting finding of this study is the im- balanced mucosal microcirculation, especially in the Mayo one score area of the affected segment. The phenomenon of local mucosal ischemia is correlated with incomplete mucosal healing in the remission of UC and a greater chance of recurrence. These results are different from certain previous studies, including enhanced CT and MR [ 13], Dynamic Contrast-enhanced Ultrasound [ 14], magnifying endoscopy and virtual chromoendoscopy (i.e., narrow band imaging) [ 15], which mostly found that mucosal blood flow was increased in the affected segment of active IBD patients and recovered to normal when they entered the remission period. The above studies were conducted from a macroscopic pers- pective. It is our speculation that although the whole mucosal blood flow increased because of the des- truction of mucosal glands and inflammatory cell in- filtration in the lamina propria, the lamina propria interstitial space was relatively increased [ 16]." 1692 2736 W2955711888.pdf 4 13 title 0.97977275 InTable 1 Patient Characteristics 2736 2770 W2955711888.pdf 4 14 separator 0.99323004 ¶ 2770 2772 W2955711888.pdf 4 15 table 0.99014723 "Patient Characteristics No. of Subjects UC patients 7 Healthy subjects 7 Median age (min, max), year UC patients 50 (22,75) Healthy subjects 48 (36,59) Sex, female 4/7 57.1% Medical history, y 15.3 Extent of disease E2 2/7 28.6% E3 5/7 71.4% Main treatment of the induction period 5-ASA 1/7 14.3% Glucocoricoid 4/7 57.1% Anti-TNF 2/7 28.6% Severity of disease Moderate 3 42.9% Severe 4 57.1% Maintenance period treatment 5-ASA 5/7 71.4% AZA 2/7 28.6% 5-ASA 5-aminosalicylic acid (Mesalamine), AZA Azathioprine" 2772 3326 W2955711888.pdf 4 16 separator 0.9841621 ¶ 3326 3328 W2955711888.pdf 4 17 title 0.95934653 Table 2 Extent of disease and the distribution of the mucosal Mayo score 3328 3401 W2955711888.pdf 4 18 table 0.9914024 "¶ Case Ascending colon Transverse/Descending colon Sigmoid colon E2 Unaffected Unaffected Affected Mayo score 1 E3 Affected Mayo score 0 Affected Mayo score 0 Affected Mayo score 1 E3 Unaffected Affected Mayo score 1 Affected Mayo score 1 E3 Affected Mayo score 0 Affected Mayo score 0 Affected Mayo score 0 E2 Unaffected Unaffected Affected Mayo score 0 E3 Affected Mayo score 0 Affected Mayo score 1 Affected Mayo score 1 E3 Unaffected Affected Mayo score 1 Affected Mayo score 1" 3401 3897 W2955711888.pdf 4 19 paratext 0.98645604 Tian et al. BMC Gastroenterology (2019) 19:114 Page 5 of 9 3897 3964 W2955711888.pdf 4 0 paratext 0.9496546 Analisis Nilai Impendasi ...124 0 29 W2588913469.pdf 7 1 separator 0.98967546 ¶ 30 32 W2588913469.pdf 7 2 text 0.99036247 "lemari es, menghasilkan nilai impedansi semakin rendah. Frekuensi yang cocok untuk pengukuran pada daging ikan nila berformalin adalah frekuensi 1 kHz – 10 kHz." 32 196 W2588913469.pdf 7 3 separator 0.99598956 ¶ 198 200 W2588913469.pdf 7 4 title 0.98083717 DAFTAR PUSTAKA 200 215 W2588913469.pdf 7 5 separator 0.995715 ¶ 217 219 W2588913469.pdf 7 6 bibliography 0.9969685 "1 Wu L, Ogawa Y, Tagawa A. Electrical Impedance Spectroscopy analysis of Eggplant Pulp and Effect of Drying and Freezing –Thawing Treatments on Its Impedance Charactersitic. Food Engineerin g. 2008;87:274 –80." 219 435 W2588913469.pdf 7 7 separator 0.97743607 ¶ 437 439 W2588913469.pdf 7 8 bibliography 0.99712723 "2 Olarte O, Barbé K, Van Moer W, Van Ingelgem Y, Hubin A. Measurement and Characterization of Glucose in NaCl Aqueous Solutions by Electrochemical Impedance Spectroscopy. Biomedical Signal Processing and Control [Internet]. Elsevier Ltd; 2014 Nov [cited 2015 Feb 27];14:9 –18. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1746809414000949" 439 806 W2588913469.pdf 7 9 separator 0.98344445 ¶ 808 810 W2588913469.pdf 7 10 bibliography 0.99298364 "3 Jaffrin MY, Morel H. Body Fluid Volumes Measurements by Impedance: A Review of Bioimpedance Spectroscopy (BIS) and Bioimpedance Analysis (BI A) Methods. Medical engineering & physics [Internet]. 2008 Dec [cited 2015 Apr 28];30(10):1257 –69. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18676172" 810 1122 W2588913469.pdf 7 11 separator 0.98863447 ¶ 1124 1126 W2588913469.pdf 7 12 bibliography 0.9972408 "4 Purwanto RE, Sujatmiko A, Mesin JT, Malang PN, Hatta JS. Identifikasi Kerusakan Sel Melalui Penga matan Perubahan Distribusi Impedansi Elektris. SENTIA. Malang: Politeknik Negeri Malang; 2009." 1126 1327 W2588913469.pdf 7 13 separator 0.97320825 ¶ 1329 1331 W2588913469.pdf 7 14 bibliography 0.99794143 "5 Fox CH, Johnson FB, Whiting J, Roller PP. Formaldehyde Fixation. Journal of Histochemistry and Cytochemistry. 1985;33(8):845 –53." 1331 1466 W2588913469.pdf 7 15 separator 0.96913993 ¶ 1468 1470 W2588913469.pdf 7 16 bibliography 0.99526834 "6 Lorenzo A De, Andreoli A, Matt hie J, Withers P, Haverkort EB, Binnekade JM, et al. Predicting Body Cell mass with Bioimpedance by Using Theoretical Methods : a Technological Review. Journal of Applied Physiol [Internet]. 1997;82:1542 –58. Available from: http://jap.physiology.org/cgi/re print/82/5/1542" 1470 1786 W2588913469.pdf 7 17 separator 0.9762236 ¶ 1788 1790 W2588913469.pdf 7 18 bibliography 0.9974863 "7 Ivorra A. A . Bioimpedance monitoring for physicians : an overview 1. Medicina per a No Metges (Medicine for non physicians). Barcelona; 2002. p. 131 –78." 1790 1950 W2588913469.pdf 7 19 separator 0.9661859 ¶ 1952 1954 W2588913469.pdf 7 20 bibliography 0.9970423 8 Noor JA. Impedance Tomography. 2010. 1954 1993 W2588913469.pdf 7 21 separator 0.94865227 ¶ 1995 1997 W2588913469.pdf 7 22 bibliography 0.9964848 "9 Riyanto B, Maddu A, Supriyanto. Pendeteksian Ti ngkat Kesegaran Filet Ikan Nila Menggunakan Pengukuran Sifat Biolistrik. Jurnal Pengolahan Hasil Perikanan Indonesia. 2012;15." 1997 2180 W2588913469.pdf 7 0 caption 0.95550543 Fig. 1 Flowchart of the inclusion and exclusion of the patients 0 63 W4248297382.pdf 3 1 separator 0.99533266 ¶ 63 65 W4248297382.pdf 3 2 title 0.9717023 Table 1 Baseline characteristics 65 98 W4248297382.pdf 3 3 separator 0.77554214 ¶ 98 100 W4248297382.pdf 3 4 table 0.99566233 "Variable TXA group (n = 63) NS group ( n= 62) Pvalue Female ( n, %) 42 (66.67) 40 (64.52) 0.81 Age (year) 78.05 ± 7.62 78.66 ± 6.95 0.64 BMI (kg/m2) 22.27 ± 3.03 22.19 ± 2.87 0.89 AO fracture classification (A1/A2/A3) 21/26/16 20/28/14 0.74 ASA classification, I –II/III –IV 22/41 20/42 0.89 Length of trauma to admission (h) 2 (1 to 6) 2 (1 to 6) 0.45 Length of admission to randomization (h) 1.5 (1 to 2.5) 2 (1 to 2.5) 0.09 Closed reduction with PFNA ( n, %) 57 (90.5) 58 (93.5) 0.65" 100 603 W4248297382.pdf 3 5 separator 0.7868267 ¶ 603 605 W4248297382.pdf 3 6 text 0.84471565 Values are n(%) or mean ± SD. Categorical data were compared among groups using the chi-squared test 605 706 W4248297382.pdf 3 7 separator 0.99558806 ¶ 706 708 W4248297382.pdf 3 8 paratext 0.8603002 BMI body mass index, PFNA proximal femoral nail antirotationMaet al. Journal of Orthopaedic Surgery and Research (2021) 16:106 Page 4 of 7 708 856 W4248297382.pdf 3 0 paratext 0.9893747 Int. J. Environ. Res. Public Health 2021 ,18, 9601 6 of 13 0 58 W3200439720.pdf 5 1 separator 0.98106456 ¶ 58 60 W3200439720.pdf 5 2 text 0.998604 "of freedom ( df) should be 3, the root mean square error of approximation (RMSEA) value should be 0.10 with the 90% confidence interval (CI), the standardized root mean square residual (SRMR) value should be 0.08, the comparative fit index (CFI) value should be 0.85, the Tucker–Lewis index (TLI) value should be 0.08, and the Akaike information criterion (AIC) is assessed as the smaller the better [ 23,24]. The 2fit index evaluates how well a hypothesized model fits data from a set of measuring items. Multivariate normality of data, acceptable sample size, no structured incomplete data, and sufficient model specification are all requirements of the 2model fit index [ 23,24]. Additionally, the convergent validity was examined by measuring the average variance extracted (AVE) and composite reliability (CR). Values of the AVE of >0.50 [ 23] and CR of >0.70 [ 38] were identified as appropriate. Moreover, Pearson’s correlation coefficients with pvalue of <0.05 were used to explore the convergent and divergent validities [ 11,23]. Data analyses were conducted using the Statistical Package for the Social Sciences (SPSS) Version 21 (SPSS, Chicago, IL, USA) and AMOS Version 25 (SPSS, Chicago, IL, USA)." 60 1296 W3200439720.pdf 5 3 separator 0.99700665 ¶ 1296 1298 W3200439720.pdf 5 4 title 0.9877385 3. Results 1298 1309 W3200439720.pdf 5 5 separator 0.99548066 ¶ 1309 1311 W3200439720.pdf 5 6 title 0.9925067 3.1. Sample Characteristics of Participants 1311 1355 W3200439720.pdf 5 7 separator 0.99568534 ¶ 1355 1357 W3200439720.pdf 5 8 text 0.9991405 "Characteristics of participants are summarized in Table 2. The mean age was 55.44 years with a standard deviation (SD) of 6.92 years, and the average FBG level was 304.49 (27.04) mg/d L. Mean (SD) DASS-21 stress, anxiety, and depression scores were 13.65 (2.99), 8.02 (0.73), and 13.61 (5.04), respectively. Mean (SD) SF-36 total QoL score, MCS, and PCS were 47.48 (8.48), 49.31 (10.38), and 45.66 (9.47), respectively. The majority of participants were female, unmarried, and had an educational ISCED level of <3, a body mass index of <25 kg/m2, a nonsmoking status, and low physical activity (Table 2)." 1357 1974 W3200439720.pdf 5 9 separator 0.99717087 ¶ 1974 1976 W3200439720.pdf 5 10 title 0.971749 Table 2. Sociodemographic and health-related status of participants. 1976 2045 W3200439720.pdf 5 11 separator 0.9464945 ¶ 2045 2047 W3200439720.pdf 5 12 table 0.99555206 "VariableConstruct Validity ( n= 294) Test–Retest Reliability ( n= 30) Mean SD n % Mean SD n % Age (years) 55.44 6.92 54.37 5.74 30 100 Gender Female 237 80.6 27 90 Male 57 19.4 3 10 Marital status Not married 159 54.1 22 73.3 Married 135 45.9 8 26.7 Education ISCED < 3 169 57.5 23 76.7 ISCED 3 125 42.5 7 23.3 BMI (kg/m2) 25 116 39.5 12 40 <25 178 60.5 18 60 Physical activity (MET-h/week) <7.5 273 92.9 29 96.7 7.5 21 7.1 1 3.3 Smoking Active smoker 33 11.2 3 10 Nonsmoker 261 88.8 27 90 FBG (mg/dL) 304.49 27.04 303.27 63.03 DASS-21 stress 13.65 2.99 16.0 1.76 DASS-21 anxiety 8.02 0.73 7.87 0.43 DASS-21 depression 13.61 5.04 14.0 4.14 SF-36 total QoL 47.48 8.48 43.70 8.73 SF-36 MCS 49.31 10.38 43.66 10.92 SF-36 PCS 45.66 9.47 43.75 7.47" 2047 2868 W3200439720.pdf 5 13 separator 0.91192865 ¶ 2868 2870 W3200439720.pdf 5 14 table 0.5688101 Notes: BMI 2870 2881 W3200439720.pdf 5 15 text 0.4904483 , 2881 2882 W3200439720.pdf 5 16 table 0.48295206 body 2882 2887 W3200439720.pdf 5 17 text 0.52914745 mass 2887 2892 W3200439720.pdf 5 18 table 0.5926356 2892 2893 W3200439720.pdf 5 19 text 0.5337429 index; FBG, fasting blood 2893 2918 W3200439720.pdf 5 20 table 0.5585138 glucose; DASS-21, 2918 2936 W3200439720.pdf 5 21 text 0.49661675 21- 2936 2940 W3200439720.pdf 5 22 table 0.57356095 item Depression, Anxiety, and 2940 2969 W3200439720.pdf 5 23 text 0.5665629 Stress 2969 2976 W3200439720.pdf 5 24 table 0.47575736 2976 2977 W3200439720.pdf 5 25 text 0.5043549 Scale; IS 2977 2986 W3200439720.pdf 5 26 table 0.5151189 CED 2986 2989 W3200439720.pdf 5 27 text 0.6130584 ", International Standard Classification of Education; MCS, mental component score; MET, metabolic equivalent of task; " 2989 3108 W3200439720.pdf 5 28 table 0.48428446 PCS 3108 3111 W3200439720.pdf 5 29 text 0.58305 ", physical component score; SD, standard deviation; SF-36," 3111 3171 W3200439720.pdf 5 30 table 0.4808263 36 3171 3174 W3200439720.pdf 5 31 text 0.5070753 -item Short Form Health Survey; Qo 3174 3208 W3200439720.pdf 5 32 table 0.5078343 L 3208 3209 W3200439720.pdf 5 33 text 0.49113202 , quality of 3209 3221 W3200439720.pdf 5 34 table 0.49012667 life 3221 3226 W3200439720.pdf 5 35 text 0.48044008 . 3226 3227 W3200439720.pdf 5 0 paratext 0.5938494 44 0 2 W4232909559.pdf 33 1 title 0.9908228 2 Landscape’s revenge 4 26 W4232909559.pdf 33 2 separator 0.9949316 ¶ 26 28 W4232909559.pdf 33 3 text 0.9997022 "Böll’s début novel is primarily concerned with life, with how one continues to live when all seems to point at death and despair. The colorful life Böll never - theless indentifies in the landscape (the landscape between 1944 – when the narrative is set – and 1948 – when the book was finished) is not a human life, and although plants are blossoming, man is not thriving, and the novel ends, accordingly, in tragedy and despair. Böll’s novel is exemplary not only because it contributes to the departure of post-war German-language literature towards new beginnings, but also because it does so by decisively moving the characters’ actions and fates indoors, both physically and mentally, a maneuver foreshad - owed – albeit still timidly, in comparison – by Walser, as shall also be shown further on. These characters’ existences are less corporal than vaporous, so overwhelming is their guilt, anguish, and perplexity. Landscape’s unrelenting indifference spawns a world of abandonment from which the artist derives no meaning, and in which he or she struggles to find his or her place and relevance (is the author dead, after all?). The landscape is neutralized as twentieth century literature turns more and more to language, as is the case with Thomas Bernhard (1931–1989), whose writings are equally central to this research, as mentioned in the introduction." 28 1404 W4232909559.pdf 33 4 separator 0.9843885 ¶ 1404 1406 W4232909559.pdf 33 5 text 0.9993648 "If the importance of landscapes once rested on “the relationships between the physical environment and human society”, thus underlying the engagement of people “with the world around them” (Whyte 2001, 7), the second half of the twentieth century abruptly severed this connection by increasingly alienating the representation of landscape in literary works." 1406 1767 W4232909559.pdf 33 6 separator 0.8001406 45 1767 1770 W4232909559.pdf 33 7 text 0.79179174 The (mental and physical) 1770 1796 W4232909559.pdf 33 8 separator 0.8521495 ¶ 1797 1799 W4232909559.pdf 33 9 text 0.9996916 indoors became the rule, and the landscape was no longer worthy of a leading role. Landscape was once again turned into the supporting act meant to hold the show’s background together, but instead of serving religion, like it did in Dürer’s day, it now seems to serve a combination of two possible outcomes, as posited in this research: either to infuse a literary text with the hue of sensibility (or prosaic poetry), or to convey a feeling of World-literature authenticity. 1799 2275 W4232909559.pdf 33 10 separator 0.97002697 ¶ 2275 2277 W4232909559.pdf 33 11 text 0.9645673 Roland Barthes’ (1915–1980) theoretical and eventually testimonial dealings 2277 2353 W4232909559.pdf 33 12 separator 0.59773993 ¶ 2354 2356 W4232909559.pdf 33 13 text 0.99742717 with the outdoors – its weather and light, its topography and melody – is a good 2356 2437 W4232909559.pdf 33 14 separator 0.9364484 ¶ 45 2438 2443 W4232909559.pdf 33 15 title 0.944664 A particularly European maneuver that was counterattacked by the rebirth of American 2443 2528 W4232909559.pdf 33 16 separator 0.98114455 ¶ 2529 2531 W4232909559.pdf 33 17 text 0.9996342 "Realism in the late 1980s, whereupon the landscape – albeit an urban one – was once again given some prominence as a link between literature (art) and society (world). Tom Wolfe’s initial manifesto “Stalking the Billion-Footed Beast: A Literary Manifesto for the New Social Novel” (1989) and, further on, Jonathan Franzen’s successful rebranding of a Tolstoy-inspired all- encompassing ambition as seen in The Corrections (2001) and Freedom (2010), were fundamen- tal to the twenty-first century Realist insurgence." 2532 3050 W4232909559.pdf 33 0 paratext 0.90972537 MARCH 22, 1965] 0 16 W2736404693.pdf 9 1 title 0.68622494 CHROMOSOME NUMBERS 16 34 W2736404693.pdf 9 2 paratext 0.57512915 113 34 38 W2736404693.pdf 9 3 separator 0.97142935 ¶ 39 41 W2736404693.pdf 9 4 title 0.98980075 ScROPHULARIACEAE 41 58 W2736404693.pdf 9 5 separator 0.9949281 ¶ 59 61 W2736404693.pdf 9 6 table 0.55371934 ANTIRRHINUM MULTIFL 61 81 W2736404693.pdf 9 7 text 0.4867285 ORUM 81 85 W2736404693.pdf 9 8 table 0.5298238 Penn 85 90 W2736404693.pdf 9 9 text 0.4874075 . 90 91 W2736404693.pdf 9 10 table 0.5752239 n = 16u*. Saddle 91 108 W2736404693.pdf 9 11 text 0.47287822 Peak 108 113 W2736404693.pdf 9 12 table 0.55664915 ", Santa Monica Mountains, Los Angeles Co., Calif., Raven 15392 (LA)." 113 184 W2736404693.pdf 9 13 separator 0.7161764 ¶ 185 187 W2736404693.pdf 9 14 table 0.7674892 "ANTIRRHINUM NUTTALLIANUM Benth. 2n = 16n. Ridge above Chinese Harbor, 900 ft., Santa Cruz Island, Santa Barbara Co., Calif., Breedlove 2793 (DS), progeny (= Raven 18179, DS)." 187 368 W2736404693.pdf 9 15 separator 0.9709737 ¶ 369 371 W2736404693.pdf 9 16 table 0.7250433 GALVESIA JUNCEA 371 387 W2736404693.pdf 9 17 bibliography 0.68644875 "(Benth.) Ball. 2n = 15u*. 14 miles south of San Quintin, Baja, Cali­ fornia, Raven 17026 (RSA)." 387 485 W2736404693.pdf 9 18 separator 0.97230375 ¶ 486 488 W2736404693.pdf 9 19 table 0.62909096 GALVE~IA SPECIOSA (Nutt) A. 488 516 W2736404693.pdf 9 20 bibliography 0.55043125 Gray. 516 522 W2736404693.pdf 9 21 table 0.47863486 2 522 524 W2736404693.pdf 9 22 bibliography 0.52394545 n 524 525 W2736404693.pdf 9 23 table 0.47886676 525 526 W2736404693.pdf 9 24 bibliography 0.5280215 = 15 526 530 W2736404693.pdf 9 25 table 0.5092217 u 530 531 W2736404693.pdf 9 26 bibliography 0.5665108 "*. San Clemente Island, Los Angeles Co., Calif., Peirson" 531 590 W2736404693.pdf 9 27 table 0.5218699 590 591 W2736404693.pdf 9 28 bibliography 0.45934948 3476 591 595 W2736404693.pdf 9 29 table 0.6116334 (RSA), progeny (DS). 595 616 W2736404693.pdf 9 30 separator 0.9587748 ¶ 617 619 W2736404693.pdf 9 31 table 0.61453044 MoHAVEA coNFERTIFLORA (Benth.) Hell 619 655 W2736404693.pdf 9 32 bibliography 0.49653953 er. 655 658 W2736404693.pdf 9 33 table 0.51319265 2 658 660 W2736404693.pdf 9 34 bibliography 0.50068057 n 660 661 W2736404693.pdf 9 35 table 0.54593736 661 662 W2736404693.pdf 9 36 bibliography 0.557577 = 662 663 W2736404693.pdf 9 37 table 0.513777 15u* 663 668 W2736404693.pdf 9 38 bibliography 0.56091744 ". Box Canyon, Riverside Co., Calif., Bates" 668 713 W2736404693.pdf 9 39 table 0.49019426 713 714 W2736404693.pdf 9 40 bibliography 0.48845023 2297 A 714 720 W2736404693.pdf 9 41 table 0.51948345 (DS). 720 726 W2736404693.pdf 9 42 separator 0.9809202 ¶ 727 729 W2736404693.pdf 9 43 bibliography 0.49237308 PENST 729 735 W2736404693.pdf 9 44 table 0.4849731 EMON 735 739 W2736404693.pdf 9 45 bibliography 0.83014625 "ALBOMARGINATUs M. E. Jones. 2n = · 8u*. 21 miles east of Newberry, San Bernardino Co., Calif., Raven 13900 (RSA)." 739 856 W2736404693.pdf 9 46 separator 0.9820163 ¶ 857 859 W2736404693.pdf 9 47 bibliography 0.5634908 PENST 859 865 W2736404693.pdf 9 48 table 0.47985554 EMON 865 869 W2736404693.pdf 9 49 bibliography 0.83957535 "CLEVELANDII A. Gray var. ANGELicus I. M. Johnst. n = 8*. Arroyo Estat6n, Isla Angel da la Guarda, Baja California, Moran 8580 (SD)." 869 1004 W2736404693.pdf 9 50 separator 0.99127555 ¶ 1005 1007 W2736404693.pdf 9 51 table 0.5669839 ScROPHULARIA CALIFORNICA 1007 1032 W2736404693.pdf 9 52 bibliography 0.39572582 Cham 1032 1037 W2736404693.pdf 9 53 table 0.4502059 . 1037 1038 W2736404693.pdf 9 54 bibliography 0.5191355 & Schlecht. subsp. CALIFORNICA. 2n = 1038 1075 W2736404693.pdf 9 55 table 0.34697905 48 1075 1078 W2736404693.pdf 9 56 bibliography 0.51439303 "u*. West Los Angeles, Los Angeles Co., Calif., Raven 15" 1078 1136 W2736404693.pdf 9 57 text 0.39206314 412 1136 1139 W2736404693.pdf 9 58 bibliography 0.38746795 (LA). 1139 1145 W2736404693.pdf 9 59 text 0.98722863 "This plant provided excellent metaphase I figures when fixed in 3 parts absolute ethanol : 1 part glacial acetic acid. Taking into ac­ count the approximate chromosome numbers published by Shaw (Aliso 5: 156-158. 1962), we consider it likely that all North American species except S. montana Wooten and poss­ ibly S. marilandica L. will prove to have n = 48." 1145 1514 W2736404693.pdf 9 60 separator 0.99560297 ¶ 1515 1517 W2736404693.pdf 9 61 table 0.81424147 "SoLANUM DOUGLAS!! Dunal. 2n 126 (DS). SoLANACEAE 12n. East Whittier, Los Angeles Co., Calif., Kyhos 62-" 1517 1627 W2736404693.pdf 9 62 separator 0.9914401 ¶ 1627 1629 W2736404693.pdf 9 63 title 0.9818535 STAPHYLEACEAE 1629 1643 W2736404693.pdf 9 64 separator 0.9939592 ¶ 1644 1646 W2736404693.pdf 9 65 text 0.9595328 "STAPHYLEA BOLANDER! A. Gray. 2n = 13n*. Near summit of Tollhouse Grade, Fresno, Co., Calif., Frampton in 1956, progeny (RSA). Apparently the first diploid in this small family to be reported from North America." 1646 1863 W2736404693.pdf 9 66 separator 0.99588287 ¶ 1864 1866 W2736404693.pdf 9 67 title 0.9855145 STYRACACEAE 1866 1878 W2736404693.pdf 9 68 separator 0.99466074 ¶ 1879 1881 W2736404693.pdf 9 69 text 0.6248295 STYRAX OFFICINALIS L. var. FULVESCENS (Eastw.) Munz 1881 1933 W2736404693.pdf 9 70 bibliography 0.4317356 & Johnst 1933 1942 W2736404693.pdf 9 71 text 0.39172247 . 2 1942 1945 W2736404693.pdf 9 72 bibliography 0.38686156 n 1945 1946 W2736404693.pdf 9 73 text 0.44375882 = 8rr*. 1946 1954 W2736404693.pdf 9 74 bibliography 0.4590229 "Main Divide Road, Santa Ana Mountains," 1954 1996 W2736404693.pdf 9 75 text 0.45537412 Orange 1996 2003 W2736404693.pdf 9 76 bibliography 0.4131835 Co 2003 2006 W2736404693.pdf 9 77 text 0.3832248 ., 2006 2008 W2736404693.pdf 9 78 bibliography 0.36887324 Calif., 2008 2016 W2736404693.pdf 9 79 text 0.417677 Wolf 2016 2021 W2736404693.pdf 9 80 bibliography 0.48235297 & 2021 2023 W2736404693.pdf 9 81 text 0.51003134 Stark 4441 (RSA), progeny. 2023 2050 W2736404693.pdf 9 82 separator 0.99486566 ¶ 2051 2053 W2736404693.pdf 9 83 title 0.98733544 VALERIANACEAE 2053 2067 W2736404693.pdf 9 84 separator 0.99410117 ¶ 2068 2070 W2736404693.pdf 9 85 text 0.95596445 "PLECTRITIS MACROCERA Torr. & Gray, n = 15*. 14.5 miles southeast of Livermore on the Mines Road, Alameda Co., Calif., Raven 18761 (DS). A new basic number for the Valeria­ naceae, which underscores the distinctiveness of Plectritis from Valerionella and other genera. " 2070 2345 W2736404693.pdf 9 86 separator 0.5065656 ¶ 2345 2346 W2736404693.pdf 9 87 text 0.98414487 The preparations were excellent. 2346 2379 W2736404693.pdf 9 88 separator 0.9938403 ¶ 2380 2382 W2736404693.pdf 9 89 table 0.85974115 "VERBENA LASIOSTACHYS Link. 2n 15411 (LA). VERBENACEAE" 2382 2439 W2736404693.pdf 9 90 separator 0.60128593 ¶ 2440 2442 W2736404693.pdf 9 91 table 0.6290829 7u*. West Los Angeles, Los Angeles Co., Calif., Raven 2442 2496 W2736404693.pdf 9 0 paratext 0.97232187 "Potravinarstvo Slovak Jo urnal of Food Sciences Volume 17 478 2023" 0 71 W4379516886.pdf 11 1 title 0.98621 1. Physical Resources 71 93 W4379516886.pdf 11 2 separator 0.98934585 ¶ 94 96 W4379516886.pdf 11 3 text 0.9996658 "Physical resources owned by avocado farmers are land whose area is different from the total land area for avocado plants in South Warkuk Ranau Di strict of 20,951.50 ha. Farmers are cultivated by avoca do through the cone sari method. Equipment owned by farmer s for cultivation to postharve st avocados in the form of hoes, pest spraying devices, flush tools, and sacks." 96 478 W4379516886.pdf 11 4 separator 0.9938401 ¶ 480 482 W4379516886.pdf 11 5 title 0.98077774 2. Human Resources 482 501 W4379516886.pdf 11 6 separator 0.9879614 ¶ 502 504 W4379516886.pdf 11 7 text 0.9995925 "Compared to other resources like capital and technology, human resources make up the majority of an organization since people are in charge of them. For example, u sing mobile phones to improve communication within the supply chain. For example between farmers and collec tors [34]." 504 793 W4379516886.pdf 11 8 title 0.98212886 Human resources in the Avocado 793 824 W4379516886.pdf 11 9 separator 0.96502614 ¶ 825 827 W4379516886.pdf 11 10 text 0.9996932 "Supply chain in South Warkuk Rana uDistrict invol ved labor in th e family and workers outside the family. Work carried out by workers in the family, namely routine activities such as watering, maintenance using pest spraying, and fertilization. While the harvest of farmers is helped by fa mily labor, other operati ons like land treatment and avocado land cleaning after harvest use daily workers from outs ide the family." 827 1262 W4379516886.pdf 11 11 separator 0.9740819 ¶ ¶ 1263 1269 W4379516886.pdf 11 12 title 0.98539954 3. Technology Resources 1269 1293 W4379516886.pdf 11 13 separator 0.99186146 ¶ 1294 1296 W4379516886.pdf 11 14 text 0.9995761 "Technology resources used by farm ers in the avocado cultivation process still use traditional methods such as hoes for land treatment, and the harvesting process is carried out manually using human labor. Refer to research [35] weeding by hand is the most common practice in Nepal. Most farm ers still manually remove weeds with small hand tools such as spades, various hand hoes (kuto, kodal o, kodali), and sickles." 1296 1725 W4379516886.pdf 11 15 title 0.97026 "Farmers' use of information technology" 1725 1767 W4379516886.pdf 11 16 text 0.999667 "Farmers' use of info rmation technology is only limit ed to mobile phones to facilitate communication between supply chain members. For example, between farmers and collectors." 1767 1948 W4379516886.pdf 11 17 separator 0.9970032 ¶ 1949 1951 W4379516886.pdf 11 18 title 0.98699194 4. Capital Resources 1952 1973 W4379516886.pdf 11 19 separator 0.9939326 ¶ 1974 1976 W4379516886.pdf 11 20 text 0.9938885 "Based on the research results on business capital obtained by f armers come from their own capital and collectors. Own capital is obtained from the revenue of the harvesting peri od of plantation crops such as coffee and rubber. In addition, some farmers also c hose to borrow capital from col lectors or middlemen. Fa rmers with narrow lands who lack a strong capital base (p roletarian) are used as opport unities for middlemen and tr ader farmers as capital owners (bourgeois) to be utilized o r exploited by providing loa ns to farmers even without loan interest and the need for labor from farmers with narrow lands [36]. As a result, because they previously felt helped during the agricultural production process, these smallholder farmers sell their crops to middlemen or farmer-traders." 1976 2790 W4379516886.pdf 11 21 separator 0.8900223 "¶ ¶ ¶" 2790 2814 W4379516886.pdf 11 22 caption 0.9944304 Figure 8 Avocado farmers and a vocado fruit marketing. 2814 2870 W4379516886.pdf 11 23 separator 0.98180205 ¶ ¶ 2872 2878 W4379516886.pdf 11 24 title 0.9902447 Supply Chain Performance 2878 2903 W4379516886.pdf 11 25 separator 0.9933042 ¶ 2905 2907 W4379516886.pdf 11 26 text 0.999436 "Supply chain performance is the performance of activities relat ed to the flow of goods, information, and funds from suppliers to end consumers [37], [38] . To find out the performance o f the supply chain in avocado agribusiness is carried out through marketing margin analysis a nd farmer’s share analysis ." 2907 3223 W4379516886.pdf 11 27 separator 0.99309754 ¶ ¶ 3225 3231 W4379516886.pdf 11 28 title 0.99080426 Marketing Margin 3231 3248 W4379516886.pdf 11 29 separator 0.992842 ¶ 3250 3252 W4379516886.pdf 11 30 text 0.9903277 "Marketing margin is the price difference producers receive from the final consumer's cost of goods. Marketing margins are used to see receipts received by each component in the marketing channel. Each stage of the marketing " 3252 3482 W4379516886.pdf 11 31 separator 0.8953879 ¶ 3482 3483 W4379516886.pdf 11 0 text 0.99969274 "by Opatrna et al. [43] showed that the serum levels of PCT were increased in PD patients without overt signs of infection compared with healthy volunteers. Butfollow-up studies revealed the plasma clearance rate of PCT correlated weakly with renal function dysfunc- tion, and it might not influence clinical decisions based on PCT [42,44]. Our meta-analysis also confirmed an ac- ceptable diagnostic accuracy for PCT testing in PD pa- tients (Sensitivity, 0.64; Specificity, 0.91; DOR: 18.33; AUROC: 0.89)." 0 522 W2113189060.pdf 10 1 separator 0.98242605 ¶ 522 524 W2113189060.pdf 10 2 text 0.9997064 "SBP is the most frequent and life-threatening infection in decompensated cirrhotic patients [45]. Owing to an inadequately immune response, clinical manifestations of SBP in cirrhotic patients may be atypical. There is considerable evidence indicating that high PCT levelsmay be related to infections in cirrhosis [25]. Although the liver is considered as the main source of PCT, a study performed by Bota et al. [46] showed that serumlevels of PCT did not significantly decrease in cirrhotic patients. Moreover, PCT had similar predictive power for infection in patients with and without cirrhosis. Inaccordance with these findings, our meta-analysis also showed that serum PCT testing has a good accuracy for the diagnosis of bacterial peritonitis in cirrhotic patients (Sensitivity, 0.86; Specificity, 0.94; DOR: 85.89; AUROC: 0.91)." 524 1385 W2113189060.pdf 10 3 separator 0.9802612 ¶ 1385 1387 W2113189060.pdf 10 4 text 0.9997163 "Some authors postulated that ascitic PCT might be more sensitive than serum PCT for the early identifica- tion of peritonitis, because bacterial infection could trig- ger peritoneal inflammatory cells to produce PCT, whichthen may accumulate in the ascitic fluid. In the present study, the pooled analysis of 5 studies [22,23,28,29,34] suggested that ascitic PCT (DOR: 80.93; AUROC: 0.96)to was similar with serum PCT (DOR: 85.89; AUROC: 0.91) in diagnosing peritonitis in cirrhotic patients. And Viallon et al. found that PCT detection in ascitic fluidwas due to hyperpermeability of peritoneum, while PCT was not synthesized by leucocytes in ascites [23]. These small and in part not significant differences rather supported the assumption of Viallon et al. that PCT detection in the ascitic fluid was the result of a pas- sive shift due to increased vascular permeability in- stead of an intraperitoneal synthesis. Considering the serious harm for the missed diagnoses of peritonitis, it is not recommended to use ascitic PCT testing as a stand-alone test, and more larger prospective trials are needed to fully elucidate the potential diagnostic value of ascitic PCT." 1387 2595 W2113189060.pdf 10 5 separator 0.98271024 ¶ 2595 2597 W2113189060.pdf 10 6 text 0.9997224 "Fungal peritonitis is a quite uncommon but potentially fatal complication both in peritoneal dialysed [47] and advanced liver cirrhosis patients [48]. The clinical char- acteristics of fungal peritonitis is not typical and easy to be misdiagnosed. In addition, fungi infections usually re- sult in treatment failure with antibacterial agents andeven removing the PD catheter. Early recognition of fun- gal peritonitis allows for timely and effective therapy with improved outcome, but it is hampered by a lack ofa reliable diagnostic tool. There is a significant body of clinical research indicates good diagnostic accuracy for the PCT test for discrimination between invasive fungalinfection and bacterial infection [6,49]. However, the dif- ferential diagnostic value of the PCT testing on fungal peritonitis has not been explored. It is speculated that the PCT testing can provide effective sensitivity and spe- cificity for distinguishing fungal peritonitis from bacter- ial peritonitis." 2597 3617 W2113189060.pdf 10 7 separator 0.9900878 ¶ 3617 3619 W2113189060.pdf 10 8 text 0.9995952 "The pooled likelihood ratio estimates (LR +and LR−) was analyzed to calculate post-test probabilities. In a vir- tual population with a 20% prevalence of peritonitis (the actual prevalence of SBP in hospitalized cirrhotic pa- tients with ascites was 10-30% [50]), use of a serum PCT test with an LR + of 11.06 would increase the posttest probability (positive predictive value) to 72%. In other words, about 3 in 4 patients with positive PCT test re- sults may have confirmed peritonitis. Likewise, in thesame population, application of a serum PCT test with a negative likelihood ratio of 0.18 would reduce the post- test probability to 5%, In other words, 1 in 20 patients with negative PCT results may have peritonitis. Using data from the subgroup with a higher PCT cut-off value (0.615 –13.7 ng/mL), a similar calculation indicated a positive post-test probability of 85% and a negative post-test probability of 7%." 3619 4572 W2113189060.pdf 10 9 separator 0.9909332 ¶ 4572 4574 W2113189060.pdf 10 10 text 0.9895011 "There was substantial heterogeneity detected for the overall results between the eighteen included studies." 4574 4684 W2113189060.pdf 10 11 separator 0.9673508 ¶ 4684 4686 W2113189060.pdf 10 12 text 0.9994227 "Potential source of heterogeneity included the different characteristics of the studies, such as methodological qua- lity, admission category, size of the study populations, different reference standards in PD or cirrhotic patients for peritonitis (ascitic PMN > 50/mm 3or > 250/mm3,r e - spectively), different countries and different human race and different methods used for measurement of PCT (LUMItest, ECLIA and the Semi-quantitative PCT-Q as-say systems). And other unrecorded differences among these studies might also contribute to the heterogeneity." 4686 5264 W2113189060.pdf 10 13 separator 0.9738754 ¶ 5264 5266 W2113189060.pdf 10 14 text 0.9961455 "Evaluation with individual patient data or meta-regression would help in this analysis of the sources of heterogeneity. However, the meta-regression would have to adjust forfactors at individual patient level, which were not available at present, therefore it limited our ability to further evalu- ate heterogeneity. On the other hand, using more homo- geneous trials could solve this difficulty, but it could induce selection bias." 5266 5711 W2113189060.pdf 10 15 separator 0.89610773 ¶ 5711 5713 W2113189060.pdf 10 16 text 0.98600656 "There are several potential limitations to our study that should be addressed. First, in our meta-analysis, various PCT testing assay tools and various PCT cut-off values were used in differ-ent included studies, and sensitivities and specificitiesYang et al" 5713 5978 W2113189060.pdf 10 17 paratext 0.96701926 . BMC Infectious Diseases 2014, 14:452 Page 11 of 13 5978 6030 W2113189060.pdf 10 18 separator 0.72006893 ¶ 6030 6032 W2113189060.pdf 10 19 paratext 0.9714979 http://www.biomedcentral.com/1471-2334/14/452 6032 6078 W2113189060.pdf 10 0 paratext 0.82806414 8 International Journal of Mathematics and Mathematical Sciences 0 64 W2042785256.pdf 7 1 separator 0.99200886 ¶ 64 66 W2042785256.pdf 7 2 math 0.90394473 /intersectiontext{PU|Pis a maximal ideal of CwithU/PU 2-torsion free }/equalmath0. Thusd/parenleftmathU/parenrightmath/bracketleftmathU, U/bracketrightmath/equalmath0. 66 234 W2042785256.pdf 7 3 separator 0.9811215 ¶ 234 236 W2042785256.pdf 7 4 text 0.8334621 Without loss of generality, we have d/parenleftmathR 236 289 W2042785256.pdf 7 5 math 0.5518223 / 289 290 W2042785256.pdf 7 6 text 0.54695815 parenrightmath 290 304 W2042785256.pdf 7 7 math 0.51963097 / 304 305 W2042785256.pdf 7 8 text 0.5257773 bracketleftmath 305 320 W2042785256.pdf 7 9 math 0.47974685 R 320 321 W2042785256.pdf 7 10 text 0.48731261 , 321 322 W2042785256.pdf 7 11 math 0.51728123 R 322 323 W2042785256.pdf 7 12 text 0.80687416 /bracketrightmath/equalmath0. This implies that 323 370 W2042785256.pdf 7 13 separator 0.6701503 ¶ 370 372 W2042785256.pdf 7 14 math 0.9239093 "0/equalmathd/parenleftBig R2/parenrightBig /bracketleftmathR,R/bracketrightmath/equalmathd/parenleftmathR/parenrightmathR/bracketleftmathR,R/bracketrightmath/plusmathRd/parenleftmathR/parenrightmath/bracketleftmathR,R/bracketrightmath/equalmathd/parenleftmathR/parenrightmathR/bracketleftmathR,R/bracketrightmath. /parenleftmath3.3/parenrightmath" 372 723 W2042785256.pdf 7 15 separator 0.9934068 ¶ 723 725 W2042785256.pdf 7 16 text 0.69858485 Therefore /bracketleftmath 725 752 W2042785256.pdf 7 17 math 0.58995813 R,d/parenleftmathR/parenrightmath/bracketrightmathR/bracketleftmathR,d/par 752 826 W2042785256.pdf 7 18 text 0.508694 en 826 828 W2042785256.pdf 7 19 math 0.56777084 leftmathR/par 828 841 W2042785256.pdf 7 20 text 0.52178216 enright 841 848 W2042785256.pdf 7 21 math 0.52612257 math/ 848 853 W2042785256.pdf 7 22 text 0.8317091 "bracketrightmath /equalmath 0. By semiprimeness of R, we have /bracketleftmathR,d/parenleftmathR/parenrightmath/bracketrightmath /equalmath 0, that is, d/parenleftmathR/parenrightmath⊆Z/parenleftmathR/parenrightmath. This completes the proof of the theorem." 853 1112 W2042785256.pdf 7 23 separator 0.9961552 ¶ 1112 1114 W2042785256.pdf 7 24 title 0.73195636 References 1114 1125 W2042785256.pdf 7 25 separator 0.92062557 ¶ 1125 1127 W2042785256.pdf 7 26 bibliography 0.99473673 "/bracketleftmath1/bracketrightmathE. C. Posner, “Derivations in prime rings,” Proceedings of the American Mathematical Society , vol. 8, pp. 1093–1100, 1957. /bracketleftmath2/bracketrightmathC. Lanski, “Di fferential identities, Lie ideals, and Posner’s theorems,” Pacific Journal of Mathematics , vol. 134, no. 2, pp. 275–297, 1988." 1127 1466 W2042785256.pdf 7 27 separator 0.6686881 1466 1467 W2042785256.pdf 7 28 bibliography 0.98884076 "¶ /bracketleftmath3/bracketrightmathH. E. Bell and W. S. Martindale III, “Centralizing mappings of semiprime rings,” Canadian Mathematical Bulletin , vol. 30, no. 1, pp. 92–101, 1987. /bracketleftmath4/bracketrightmathI. N. Herstein, “A note on derivations,” Canadian Mathematical Bulletin , vol. 21, no. 3, pp. 369–370, 1978." 1467 1799 W2042785256.pdf 7 29 separator 0.6391205 1799 1800 W2042785256.pdf 7 30 bibliography 0.99353564 "¶ /bracketleftmath5/bracketrightmathV. De Filippis, “On derivations and commutativity in prime rings,” International Journal of Mathematics and Mathematical Sciences , no. 69–72, pp. 3859–3865, 2004." 1800 2001 W2042785256.pdf 7 31 separator 0.8006083 ¶ 2001 2003 W2042785256.pdf 7 32 bibliography 0.9976421 "/bracketleftmath6/bracketrightmathK. I. Beidar, W. S. Martindale III, and A. V. Mikhalev, Rings with Generalized Identities , vol. 196 of Monographs and Textbooks in Pure and Applied Mathematics , Marcel Dekker, New York, NY, USA, 1996." 2003 2242 W2042785256.pdf 7 33 separator 0.6315699 ¶ 2242 2244 W2042785256.pdf 7 34 bibliography 0.99795765 "/bracketleftmath7/bracketrightmathT. K. Lee, “Semiprime rings with di fferential identities,” Bulletin of the Institute of Mathematics Academia Sinica , vol. 20, no. 1, pp. 27–38, 1992." 2244 2431 W2042785256.pdf 7 35 separator 0.63108325 ¶ 2431 2433 W2042785256.pdf 7 36 bibliography 0.99791795 "/bracketleftmath8/bracketrightmathM. Bre ˇsar, “One-sided ideals and derivations of prime rings,” Proceedings of the American Mathematical Society , vol. 122, no. 4, pp. 979–983, 1994." 2433 2620 W2042785256.pdf 7 37 separator 0.63708 2620 2621 W2042785256.pdf 7 38 bibliography 0.9892182 "¶ /bracketleftmath9/bracketrightmathV. K. Kharchenko, “Di fferential identities of prime rings,” Algebra i Logika , vol. 17, no. 2, pp. 155–168, 1978." 2621 2772 W2042785256.pdf 7 39 separator 0.7058977 2772 2773 W2042785256.pdf 7 40 bibliography 0.99109 "¶ /bracketleftmath10/bracketrightmathC. Lanski, “An Engel condition with derivation,” Proceedings of the American Mathematical Society , vol. 118, no. 3, pp. 731–734, 1993." 2773 2947 W2042785256.pdf 7 41 separator 0.6838631 2947 2948 W2042785256.pdf 7 42 bibliography 0.98645645 "¶ /bracketleftmath11/bracketrightmathW. S. Martindale III, “Prime rings satisfying a generalized polynomial identity,” Journal of Algebra , vol. 12, pp. 576–584, 1969. /bracketleftmath12/bracketrightmathI. N. Herstein, Topics in Ring Theory , The University of Chicago Press, , Chicago, Ill, USA, 1969." 2948 3254 W2042785256.pdf 7 43 separator 0.6666271 3254 3255 W2042785256.pdf 7 44 bibliography 0.99135214 "¶ /bracketleftmath13/bracketrightmathH. E. Bell and Q. Deng, “On derivations and commutativity in semiprime rings,” Communications in Algebra , vol. 23, no. 10, pp. 3705–3713, 1995." 3255 3438 W2042785256.pdf 7 45 separator 0.6314044 ¶ 3438 3440 W2042785256.pdf 7 46 bibliography 0.9979208 "/bracketleftmath14/bracketrightmathC.-L. Chuang, “GPI’s having coe fficients in Utumi quotient rings,” Proceedings of the American Mathematical Society , vol. 103, no. 3, pp. 723–728, 1988." 3440 3630 W2042785256.pdf 7 47 separator 0.60814095 ¶ 3630 3632 W2042785256.pdf 7 48 bibliography 0.99789166 "/bracketleftmath15/bracketrightmathC. Faith and Y. Utumi, “On a new proof of Lito ff’s theorem,” Acta Mathematica Academiae Scientiarum Hungaricae , vol. 14, pp. 369–371, 1963." 3632 3810 W2042785256.pdf 7 49 separator 0.7086121 ¶ 3810 3812 W2042785256.pdf 7 50 bibliography 0.9976645 "/bracketleftmath16/bracketrightmathK. I. Beidar, “Rings of quotients of semiprime rings,” Vestnik Moskovskogo Universiteta , vol. 33, no. 5, pp. 36–43, 1978." 3812 3972 W2042785256.pdf 7 0 paratext 0.97569853 261 0 3 W2974869847.pdf 15 1 separator 0.970788 ¶ 3 5 W2974869847.pdf 15 2 title 0.9712497 "CENA DE INTERIOR II E QUEERMUSEU: CARTOGRAFIAS DAS DIFERENÇAS NA ARTE BRASILEIRA SILENCIADAS EM PORTO ALEGRE" 5 117 W2974869847.pdf 15 3 separator 0.9775449 ¶ 118 120 W2974869847.pdf 15 4 contact 0.8704569 Eduardo Cristiano Hass da Silva 120 152 W2974869847.pdf 15 5 paratext 0.5055503 ¶ Bárbara Virgínia Groff 154 179 W2974869847.pdf 15 6 bibliography 0.7888913 da SilvaPalíndromo, v. 11, n. 25, p. 261-265, set - dez 2019 179 240 W2974869847.pdf 15 7 text 0.9895545 "ráveis é de 7,16% do total enquanto o uso de robôs no contingente de intera- ções desfavoráveis é de 12,97%. Vale interpretar dois aspectos desses percen- tuais apontados pelo estudo: de que pelo levantamento feito pela FGV, em relação ao volume de interação de cada grupo (favoráveis e desfavoráveis) mostra que o uso de robôs em favor da exposição é infinitamente menor comparativamente ao volume de apoiadores, e o de robôs contra a exposição é praticamente da mesma escala se comparado ao todo de interações desfa- voráveis. Isso mostra que de fato uma imensa maioria que se manifestou era a favor da exposição (G1, 2018, online)." 240 895 W2974869847.pdf 15 8 separator 0.94211453 ¶ 895 897 W2974869847.pdf 15 9 text 0.99764425 "Pesquisas como essas são importantes por apresentar dados sobre o perigo dessa disseminação através de distintas redes sociais de notícias e boatos que podem levar à censura de exposições que se propõem a pensar o diferente como alterida- de, a apontar aspectos sociais que não são considerados dentro do “padrão”, porém que abarcam um contingente de pessoas diversas. Conforme analisa Guacira Louro (2001):" 897 1319 W2974869847.pdf 15 10 separator 0.9891989 ¶ 1319 1321 W2974869847.pdf 15 11 text 0.99950266 "Hoje, as chamadas “minorias” sexuais estão muito mais visíveis e, consequen- temente, torna-se mais explícita e acirrada a luta entre elas e os grupos con- servadores. A denominação que lhes é atribuída parece, contudo, bastante imprópria. Como afirma em seu editorial a revista La Gandhi Argentina, “as minorias nunca poderiam se traduzir como uma inferioridade numérica, mas sim como maiorias silenciosas que, ao se politizar, convertem o gueto em ter - ritório e o estigma em orgulho – gay, étnico, de gênero”. Sua visibilidade tem efeitos contraditórios: por um lado, alguns setores sociais passam a demons- trar uma crescente aceitação da pluralidade sexual e, até mesmo, passam a consumir alguns de seus produtos culturais; por outro lado, setores tradicio- nais renovam (e recrudescem) seus ataques, realizando desde campanhas de retomada dos valores tradicionais da família até manifestações de extrema agressão e violência física (LOURO, 2001, p. 542)." 1321 2314 W2974869847.pdf 15 12 separator 0.9854174 ¶ 2314 2316 W2974869847.pdf 15 13 text 0.99900186 "Os ataques e discursos de ódio aconteceram em diferentes espaços da internet: vídeos no Youtube com seus comentários, páginas e perfis no Facebook, campanhas de boicote ao Banco Santander pelo Twitter, textos em blogs, enfim as possibilidades foram diversas e podem servir como material de outros artigos ou trabalhos acadê- micos. Como um breve exemplo de análise, selecionamos alguns comentários de reportagens sobre o “Queermuseu” que foram postados por perfis de usuários do Fa- cebook em sites de notícias como GaúchaZH e G1. A escolha por meios de comuni- cação relacionados com a Rede Globo ocorreu devido a abrangência e popularidade desses veículos de comunicação." 2316 3011 W2974869847.pdf 15 14 separator 0.9792173 ¶ 3011 3013 W2974869847.pdf 15 15 text 0.9968825 "A reportagem de Gustavo Foster intitulada “‘Queermuseu’: quais são e o que representam as obras que causaram o fechamento da exposição”, de 11 de setembro de 2017, apresenta algumas imagens das obras e entre as selecionadas está a “Cena de Interior II”. Eis alguns comentários localizados abaixo do texto da reportagem113 :" 3013 3346 W2974869847.pdf 15 16 separator 0.99034977 ¶ 3347 3349 W2974869847.pdf 15 17 text 0.941348 "COMENTÁRIO 1: lixo. Imbecilidade humana....aliás,,,,onde estão os movimen- tos de defesa do negro?!!! colocam um negro sendo currado por um branco e praticando sexo oral em outro branco e todos calados!!! [...]" 3349 3565 W2974869847.pdf 15 18 separator 0.6108366 ¶ 3565 3567 W2974869847.pdf 15 19 text 0.8830562 COMENTÁRIO 2: Eu, particularmente, achei deprimente, altamente precon- ¶ 3567 3640 W2974869847.pdf 15 20 bibliography 0.83535653 "11.A grafia e digitação não sofreram alterações, sendo destacadas em itálico as gírias e os erros ortográficos. Além disso, preferimos não identificar nesse artigo o nome do perfil de Facebook que realizou o comentário nos sites de notícias." 3640 3885 W2974869847.pdf 15 0 text 0.9989064 "and reoperation rates were only marginally higher com- pared with 7240 unilateral TAPP operations [ 4]." 0 105 W2078289653.pdf 1 1 separator 0.96231025 ¶ 105 107 W2078289653.pdf 1 2 text 0.9993046 "On that scientific basis, laparoscopic/endoscopic repair of bilateral inguinal hernia was recommended by theEuropean Hernia Society [ 5], the International Endohernia Society [ 6], European Association of Endoscopic Surgery [7] and the Royal College of Surgeons of England (RCS— Commissioning guide: groin hernias 2013) [ 8]." 107 440 W2078289653.pdf 1 3 separator 0.9590061 ¶ 440 442 W2078289653.pdf 1 4 text 0.999669 "When the laparoscopic technique is used to repair a clinically diagnosed unilateral inguinal hernia, it is possibleto also explore the contralateral side. In 10–25 % of cases, an asymptomatic, preoperatively inapparent, occult inguinal hernia is identified on the other side [ 9,10]. A prospective randomized trial demonstrated that a significant proportion of incidental defects will progress to a symptomatic hernia if left untreated [ 9]. Accordingly, contralateral occult inguinal hernia found at the time of laparoscopic transabdominal preperitoneal patchplasty (TAPP) repair should also be re- paired [ 11]. The proportion of bilateral inguinal hernias in large clinical series repaired in TAPP technique was 28.5 % [4]. A similar proportion of 28.5 % bilateral inguinal hernias is given in the Herniamed Registry [ 12] for inguinal hernias repaired using a laparoscopic/endoscopic technique." 442 1365 W2078289653.pdf 1 5 separator 0.96382475 ¶ 1365 1367 W2078289653.pdf 1 6 text 0.99968857 "Furthermore, studies have demonstrated that following repair of a unilateral inguinal hernia, the likelihood of onsetof an inguinal hernia on the contralateral side had to be anticipated in around 1 % of cases for each year of follow- up [13,14]." 1367 1620 W2078289653.pdf 1 7 separator 0.9187835 ¶ 1620 1622 W2078289653.pdf 1 8 text 0.99970114 "In view of the favorable outcome of bilateral repair and the persistent risk of new onset of an inguinal hernia on theother side, which is set at 1 % per year following unilateral repair of inguinal hernia, the merits of prophylactic repair of a healthy groin are discussed in the literature. Zendejas et al.[13] speak about the ‘‘role for prophylaxis during endoscopic inguinal hernia repair,’ ’ and Lal et al. [ 14] ask ‘‘Is unilateral laparoscopic inguinal hernia repair a job half done?’ ’" 1622 2126 W2078289653.pdf 1 9 separator 0.9831399 ¶ 2126 2128 W2078289653.pdf 1 10 text 0.99966013 "The aim of the present analysis of the perioperative findings for 15,176 unilateral and bilateral TAPP op- erations from the Herniamed Registry was to investigatewhether the excellent results obtained for the high-volume center mentioned above could be reproduced on a large scale in several hospitals where surgeons have varyingdegrees of experience. Based on these multicenter data, it will also be easier to assess whether the perioperative outcome justifies a broad expansion of the indication toprophylactic surgical repair of the healthy side." 2128 2688 W2078289653.pdf 1 11 separator 0.9896857 ¶ 2688 2690 W2078289653.pdf 1 12 title 0.98926014 Patients and methods 2690 2711 W2078289653.pdf 1 13 separator 0.99562347 ¶ 2711 2713 W2078289653.pdf 1 14 text 0.9996016 "The Herniamed quality assurance study is a multicenter, in-ternet-based hernia registry into which 358 participating hospitals/surgeons in Germany, Austria and Switzerland(status: April 2013) had entered data prospectively on their patients who had undergone hernia surgery [ 12]. The analysis now presented here compared the prospectively collected data of all patients who had undergone either unilateral orbilateral repair of inguinal hernia in transabdominal preperitoneal patchplasty (TAPP) between September 2009 and April 2013. Inclusion criteria were minimum age of16 years, primary inguinal hernia and elective unilateral or bilateral TAPP operation performed under inpatient condi- tions. In total, 15,176 patients were enrolled. Of these pa- tients, 10,887 had a unilateral (71.7 %) and 4,289 (28.3 %) a bilateral inguinal hernia." 2713 3575 W2078289653.pdf 1 15 separator 0.97756493 ¶ 3575 3577 W2078289653.pdf 1 16 text 0.99960226 "The data on the TAPP operations recorded in the Her- niamed Registry originated from 181 out of 358 par- ticipating institutions. Forty-three centers, each of whichhad more than 100 operations, accounted for 77.2 % of the procedures. The remaining 138 centers thus supplied data on 22.8 % operations. Data on 50 % of all unilateral andbilateral TAPP operations came from only 15 hospitals." 3577 3975 W2078289653.pdf 1 17 separator 0.9663271 ¶ 3975 3977 W2078289653.pdf 1 18 text 0.99909234 "The demographic and surgery-related parameters in- cluded age (years), sex (m/w), ASA classification (I–IV) aswell as the proportion of scrotal inguinal hernias and the hernia defect size based on EHS classification (Grade I–III)." 3977 4210 W2078289653.pdf 1 19 separator 0.853009 ¶ 4210 4212 W2078289653.pdf 1 20 text 0.99971914 "The target variables were intra- and postoperative compli-cation rates, number of reoperations as well as the duration of operation and length of hospital stay. The categorical data are displayed as absolute and relative frequencies, andcontinuous variables are displayed as mean, median, stan- dard deviation and ranges. For the bilateral patient group, data on the variables given for both sides operated on wereaggregated. For inguinal hernia defects of different sizes, the side with the larger defect is given. Classification as scrotal hernia was based on the presence of at least one scrotalhernia for bilateral inguinal hernia. Intra- and postoperative complications were recorded if a complication presented on at least one side. The same method was used to presentdetails of any reoperation." 4212 5029 W2078289653.pdf 1 21 separator 0.9332071 ¶ 5029 5031 W2078289653.pdf 1 22 text 0.9996199 "All analyses were performed with the software SAS 9.2 (SAS Institute Inc., Cary, NY, USA) and deliberately re-viewed to the full level of significance. Each pvalue B0.05 thus represents a statistically significant result. To discern differences between the groups in univariate analysis,Fisher’s exact test was used for categorical target variables, and the t test for continuous target variables. For data that did not follow the normal distribution, as in the case ofduration of operation and length of stay, the distribution was first transformed with the natural logarithm. To rule out any skewing of data caused by different patient char-acteristics, the results of univariate analyses were verified through multivariate analyses in which, in addition to lat- erality, other influence parameters were simultaneouslyreviewed. To assess influence factors in multivariate ana- lysis, the general linear model was used for continuous" 5031 5980 W2078289653.pdf 1 23 paratext 0.9857535 3734 Surg Endosc (2015) 29:3733–3740 5980 6016 W2078289653.pdf 1 24 separator 0.62808454 ¶ 6016 6018 W2078289653.pdf 1 25 paratext 0.97538435 123 6018 6022 W2078289653.pdf 1 0 paratext 0.973647 "ISSN: 2658 -8455 Volume 3, Issue 1 -1 (2022), pp. 314-327 © Authors: CC BY -NC-ND ¶ 314 www.ijafame.org" 0 189 W4220975975.pdf 0 1 separator 0.87646383 ¶ ¶ 191 197 W4220975975.pdf 0 2 title 0.9821127 Employee Relations Practices and Firm performance : 197 249 W4220975975.pdf 0 3 separator 0.56613064 ¶ 250 252 W4220975975.pdf 0 4 title 0.98529047 A Conceptual Model Proposal 252 280 W4220975975.pdf 0 5 separator 0.97276074 "¶ ¶" 282 292 W4220975975.pdf 0 6 contact 0.9877221 "Abdeljalil MILIANI , (PhD Student ) Faculty of Legal, Economic and Social Sciences of Tangier Abdelmalek Essaadi University, Tangier, Morocco ¶ Aziz EL KHAZZAR , (PhD Professor ) Faculty of Legal, Economic and Social Sciences of Tangier Abdelmalek Essaadi University, Tangier, Morocco ¶ Imad AIT LHASSAN , (PhD ) National School of Business and Management of Tangier Abdelmalek Essaadi University , Tangier, Morocco ¶ Correspondence address : Faculty of Legal, Economic and Social Sciences of Tangier BP. 1373 - Poste principale - Tangier Abdelmalek Essaadi University Morocco (Tangier) abdeljalil.miliani@gmail.com" 292 965 W4220975975.pdf 0 7 separator 0.9927359 ¶ 967 969 W4220975975.pdf 0 8 text 0.8275356 "Disclosure Statement : Authors are not aware of any findings that might be perceived as affecting the objectivity of this study" 969 1101 W4220975975.pdf 0 9 separator 0.70849365 ¶ 1103 1105 W4220975975.pdf 0 10 text 0.8308283 Conflict of Interest : The authors report no conflicts of interest. 1105 1174 W4220975975.pdf 0 11 separator 0.992656 ¶ 1176 1178 W4220975975.pdf 0 12 paratext 0.9567955 Cite this article : 1178 1199 W4220975975.pdf 0 13 separator 0.8475892 ¶ 1200 1202 W4220975975.pdf 0 14 bibliography 0.91803676 "MILIANI, A., EL KHAZZAR, A., & AIT LHASSAN, I. (2022). Employee Relations Practices and Firm performance: A Conceptual Model Proposal." 1203 1341 W4220975975.pdf 0 15 separator 0.7463821 ¶ 1342 1344 W4220975975.pdf 0 16 bibliography 0.49393955 International 1344 1358 W4220975975.pdf 0 17 paratext 0.5544091 Journal of Accounting 1358 1380 W4220975975.pdf 0 18 bibliography 0.47706738 , 1380 1381 W4220975975.pdf 0 19 paratext 0.7893293 "Finance, Auditing, Management and Economics, 3(1 -1), 314 -327. https://doi.org/10.528 1/zenodo.5903278" 1381 1488 W4220975975.pdf 0 20 separator 0.6327963 ¶ 1491 1493 W4220975975.pdf 0 21 paratext 0.94795686 "License This is an open access article under the CC BY -NC-ND license ¶ ¶ Received: January 05, 2022 Published online: January 3 0, 202 2 ¶ ¶ ¶ International Journal of Accounting, Finance, Auditing, Management and Economics - IJAFAME ISSN: 2658 -8455 Volume 3, Issue 1-1 (2022)" 1493 1819 W4220975975.pdf 0 0 paratext 0.92637926 18/O16Oand13C/12Cratios 375 0 27 W2067186435.pdf 9 1 separator 0.9630953 ¶ 27 29 W2067186435.pdf 9 2 title 0.87524813 REFERENCES 29 40 W2067186435.pdf 9 3 separator 0.98382676 ¶ 40 42 W2067186435.pdf 9 4 bibliography 0.9967484 "Bottinga, Y. and Craig, H. 1969. Oxygen isotope frac- and Broecker, W. 1987. Simulations of the HDO and H218O atmospheric cycles using the NASA GISS gen- tionation between CO2and water and the isotopic composition of marine atmospheric CO2.Earth eral circulation model: The seasonal cycle for present day condition. J. Geophys. Res. 92, 14739–14760. Planet. Sci. L ett. 5, 285–295." 42 430 W2067186435.pdf 9 5 separator 0.975595 ¶ 430 432 W2067186435.pdf 9 6 bibliography 0.99809873 Buchmann, N., Guehl, J.-M., Barigah, T. S. and Ehler- Keeling, C. D., Mook, W. G. and Tans, P. P. 1979. 432 536 W2067186435.pdf 9 7 separator 0.8668493 ¶ 536 538 W2067186435.pdf 9 8 bibliography 0.99773556 Recent trends in the 13C/12C ratio of atmospheric inger, J. R. 1997. Interseasonal comparison of CO2concentrations, isotopic composition, and carbon cyc- carbon dioxide. Nature 277, 121–123. 538 729 W2067186435.pdf 9 9 separator 0.96645415 ¶ 729 731 W2067186435.pdf 9 10 bibliography 0.9976662 "Leaney, F. W., Osmond, C. B., Allison, G. B. and ling in an Amazonian rainforest (French Guiana). Oec- ologia 110, 120–131. Ziegler, H. 1985. Hydrogen-isotope composition of leaf water in C3andC4plants: its relationship to the Burk, R. L. 1979. Factors a Vecting18O/16O ratios in cellulose. University of Washington. PhD Disserta- hydrogen-isotope composition of dry matter. Planta 164, 215–220. tion, 126 p." 731 1148 W2067186435.pdf 9 11 separator 0.9707711 ¶ 1148 1150 W2067186435.pdf 9 12 bibliography 0.99795043 "Dixon, R. K., Brown, S., Houghton, R. A., Solomon, Lloyd, J., Kruijt, B., Hollinger, D. Y., Grace, J., Francey, R. J., Wong, S.-C., Kelliher, F. M., Miranda, A. C., A. M., Trexler, M. C. and Wisniewski, J. 1994. Carbon pools and flux of global forest ecosystems. Science Farquhar, G. D., Gash, J. H. C., Vygodskaya, N. N., Wright, I. R., Miranda, H. S. and Schulze, E.-D. 1996. 263, 185–190." 1150 1547 W2067186435.pdf 9 13 separator 0.9385915 ¶ 1547 1549 W2067186435.pdf 9 14 bibliography 0.997643 "Epstein, S. and Mayeda, T. 1953. Variations of 18O con- Vegetation e Vects on the isotopic composition of atmospheric CO2at local and regional scales: Theoret- tent of water from natural sources. Geochim. et Cosmo- chim. Acta 42, 213–224. ical aspects and comparison between a rain forest in Amazonia and a boreal forest in Siberia. Aust. J. Pl. Farquhar, G. D., O’Leary, M. H. and Berry, J. A. 1982." 1549 1956 W2067186435.pdf 9 15 separator 0.8896758 ¶ 1956 1958 W2067186435.pdf 9 16 bibliography 0.99639916 On the relationship between carbon isotope discrim- Physiol .23, 371–399. 1958 2032 W2067186435.pdf 9 17 separator 0.9453156 ¶ 2032 2034 W2067186435.pdf 9 18 bibliography 0.99787605 "Merwe, N. J. van der and Medina, E. 1989. Photosyn- ination and intercellular carbon dioxide concentration in leaves. Aust. J. Pl. Physiol .9, 121–137. thesis and 13C/12C ratios in Amazonian rain forests." 2034 2241 W2067186435.pdf 9 19 separator 0.6793409 ¶ 2241 2243 W2067186435.pdf 9 20 bibliography 0.99463344 "Geochim. Cosmochim. Acta 53, 1091–1094. Farquhar, G. D. and Lloyd, J. 1993. Carbon and oxygen isotope e Vects in the exchange of carbon dioxide Moreira, M. Z., Sternberg, L. da S. L., Martinelli, L. A., Victoria, R. L., Barbosa, E. M., Bonates, L. C. M. and between terrestrial plants and the atmosphere. In: Stable isotopes and plant carbon–water relations (eds. Nepstad, D. C. 1997. Contribution of transpiration to forest ambient vapour based on isotopic measure- Ehleringer, J. R., Hall, A. E. and Farquhar, G. D.). Academic Press, San Diego, pp. 47–70. ments. Global Change Biology .3, 439–450." 2243 2853 W2067186435.pdf 9 21 separator 0.971822 ¶ 2853 2855 W2067186435.pdf 9 22 bibliography 0.99760056 "Nepstad, D. C., Carvalho, C. R. de, Davidson, E. A., Farquhar, G. D., Lloyd, J., Taylor, J. A., Flanagan, L. B., Syverstsen, J. P., Hubick, K. T., Wong, S. C. and Jipp, P. H., Lefebvre, P. A., Negreiros, G. H., Silva, E. D. da, Stone, T. A., Trumbore, S. E., Vieira, S. 1994. Ehleringer, J. R. 1993. Vegetation e Vects on the isotope composition of oxygen in atmospheric CO2.Nature The role of deep roots in the hydrological and carbon cycles of Amazonian forests and pastures. Nature 363, 439–443." 2855 3362 W2067186435.pdf 9 23 separator 0.9693861 ¶ 3362 3364 W2067186435.pdf 9 24 bibliography 0.9978211 Flanagan, L. B. and Varney, G. T. 1995. Influence of 372, 666–669. 3364 3430 W2067186435.pdf 9 25 separator 0.9483288 ¶ 3430 3432 W2067186435.pdf 9 26 bibliography 0.9976213 "Quay, P., King, S., Wilbur, D. and Wofsy, S. 1989. 13C/ vegetation and soil CO2exchange on the concentra- tion and stable oxygen isotope ratio of atmospheric 12C of atmospheric CO2in the Amazon basin: Forest and river sources. J. Geophys. Res. 94, 18327–18336. CO2within a Pinus resinosa canopy. Oecologia 101, 37–44. Sokal, R. R. and Rohlf, F. J. 1981. Biometry . Freeman, New York. Francey, R. J. and Tans, P. P. 1987. Latitudinal variation in oxygen-18 of atmospheric CO2.Nature 327, Sternberg, L. da S. L., Moreira, M. Z., Martinelli, L. A., Victoria, R. L. Barbosa, E. M., Bonates, L. C. M., 495–497." 3432 4050 W2067186435.pdf 9 27 separator 0.9592062 ¶ 4050 4052 W2067186435.pdf 9 28 bibliography 0.99760294 "Friedli, H., Siegenthaler, U., Rauber, D. and Oeschger, H. Nepstad, D. C. 1997. Carbon dioxide recycling in two Amazonian tropical forests. Agric. For. Meteorol. 88, 1987. Measurements of concentration, 13C/12C and 18O/16O ratios of tropospheric carbon dioxide over 259–268." 4052 4331 W2067186435.pdf 9 29 separator 0.9750818 ¶ 4331 4333 W2067186435.pdf 9 30 bibliography 0.9980348 Tans, P. P., Fung, I. Y. and Takahashi, T. 1990. Observa- Switzerland. T ellus 39B, 80–88. 4333 4424 W2067186435.pdf 9 31 separator 0.9535233 ¶ 4424 4426 W2067186435.pdf 9 32 bibliography 0.9975796 "Grace, J., Lloyd, J., McIntyre, J., Miranda, A. C., tional constraints on the global atmospheric CO2budget . Science 247, 1431–1438. Meier, P., Miranda, H. S., Nobre, C. A., Moncrie V, J., Massheder, J., Mali, Y., Wright, I. R. and Gash, J. H. C. Tans, P. P. 1993. Observational strategy for assessing the role of terrestrial ecosystems in the global carbon 1995. Carbon dioxide uptake by an undisturbed trop- ical rainforest in south west Amazonia, 1992 to 1993. cycle: scaling down to regional levels. In: Scaling physiological processes: leaf to globe (eds. Ehleringer, Science 2709, 778–780." 4426 5030 W2067186435.pdf 9 33 separator 0.97665524 ¶ 5030 5032 W2067186435.pdf 9 34 bibliography 0.99561965 "Hesterberg, R. and Siegenthaler, U. 1991. Production J. R. and Field, C. B.) Academic Press. San Diego, pp. 179–190. and stable isotopic composition of CO2in a soil near Bern, Switzerland. T ellus 43B, 197–205. Tans, P. P. 1998. Oxygen isotopic equilibration between carbon dioxide and water in soils. T ellus 50B, 163–178. Jouzel, J., Russell, G., Suozzo, R., Koster, R., White, J. " 5032 5422 W2067186435.pdf 9 35 separator 0.60926026 ¶ 5422 5423 W2067186435.pdf 9 36 bibliography 0.9963331 Tellus 50B (1998), 4 5423 5444 W2067186435.pdf 9 0 title 0.5500121 Öz 0 2 W2808438167.pdf 0 1 separator 0.9935143 ¶ 2 4 W2808438167.pdf 0 2 title 0.6762574 Renal tüberkül 4 19 W2808438167.pdf 0 3 text 0.6169786 oz 19 21 W2808438167.pdf 0 4 title 0.73812944 akciğer tüberkülozunun lenfohematojen yayılımı sonu 21 73 W2808438167.pdf 0 5 text 0.49691328 cunda 73 78 W2808438167.pdf 0 6 title 0.5035153 geliş 78 84 W2808438167.pdf 0 7 text 0.61960846 ir. 84 87 W2808438167.pdf 0 8 separator 0.8091517 ¶ 88 90 W2808438167.pdf 0 9 text 0.9985526 "Renal tüberkülozun en önemli bulgusu steril pyüridir. Gelişmekte olan ülkelerde Addison hastalığının %10-15’inden tüberküloz hastalığı sorumludur. Tüberküloza bağlı adrenal tutulum bilateral adrenal genişleme, atrofi ve kalsifikasyon şeklinde görülebilir. Mycobacterium tuberculosis komplekse bağlı adrenal bezlerin infeksiyonu hematojen yaylılım sonucu gelişir. Klinik bulguları yıllar sonra belirgin olabilir, asemptomatik infeksiyon oldukça sıktır. Bu yazıda, önceden Addison hastalığı (adrenokortikal yetmezlik) tanısı alan 60 yaşında bir kadın hastada saptanan renal tüberküloz sunuldu ." 90 695 W2808438167.pdf 0 10 separator 0.98402214 ¶ 696 698 W2808438167.pdf 0 11 title 0.40996766 Anahtar Kelimeler 698 716 W2808438167.pdf 0 12 text 0.45762682 : Addison hastalığı ,renal tüberküloz,steril pyüri 716 767 W2808438167.pdf 0 13 separator 0.9950129 ¶ 768 770 W2808438167.pdf 0 14 title 0.9255021 Abstract 770 779 W2808438167.pdf 0 15 separator 0.9936664 ¶ 779 781 W2808438167.pdf 0 16 text 0.99540544 "Renal tuberculosis is the result of lymphohematogenous spread of pulmonary tuberculosis. The most important finding of renal tuberculosis is sterile pyuria. Tuberculosis is responsible for 10-15% of Addison's disease in developing countries. Tuberculous adrenal involvement can be seen as bilateral adrenal enlargement, atrophy and calcification. Infection of mycobacterium tuberculosis complex adnexal glands develops hematogenous spreading outcome. Clinical findings may be evident after many years, asymptomatic infection is quite frequent. In this article, a 60-year-old female patient previously diagnosed with Addison's disease (adrenocortical insufficiency) with renal tuberculosis was presented ." 781 1500 W2808438167.pdf 0 17 separator 0.92686427 ¶ 1502 1504 W2808438167.pdf 0 18 text 0.8295194 Key words: Addison’s disease, renal tuberculosis, steril pyuria 1504 1570 W2808438167.pdf 0 19 separator 0.9923402 ¶ 1570 1572 W2808438167.pdf 0 20 contact 0.9945829 "Sorumlu Yazar*: Salih Cesur, Ankara Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği,Ankara E-posta: scesur89@yahoo.com ORCID: 0000-0003-4960-7375" 1572 1761 W2808438167.pdf 0 21 separator 0.60153234 ¶ 1761 1763 W2808438167.pdf 0 22 paratext 0.95743966 "Received 28.12.2017 accepted 12.3.2018 Doi: 10.18663/tjcl.372220Turkish Journal of Clinics and Laboratory" 1763 1872 W2808438167.pdf 0 23 separator 0.9883679 ¶ 1872 1874 W2808438167.pdf 0 24 title 0.9921543 Addison hastalığı ile renal tüberküloz birlikteliği 1874 1926 W2808438167.pdf 0 25 separator 0.99068373 ¶ 1926 1928 W2808438167.pdf 0 26 contact 0.9853599 "1 Ankara Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği,Ankara 2 Kırıkkale Üniversitesi Tıp Fakültesi,Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Kırıkkale 3 Keçiören Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği,Ankara 4 Ankara Eğitim ve Araştırma Hastanesi, Tıbbi Mikrobiyoloji Kliniği, AnkaraRenal tuberculosis with Addison's disease" 1928 2326 W2808438167.pdf 0 27 separator 0.9886656 ¶ 2326 2328 W2808438167.pdf 0 28 contact 0.87909913 "Çiğdem ATAMAN HATİPOĞLU1 , Salih CESUR*1 , Cemal BULUT2 , Emine ERGÜN3 , Sami KINIKLI1 , Taliha KARAKÖK1 , Serap YAĞCI4 , Ali PEKCAN DEMİRÖZ1" 2328 2517 W2808438167.pdf 0 29 separator 0.9787394 ¶ 2517 2519 W2808438167.pdf 0 30 paratext 0.88621175 262Olgu SunumuTo cite this article: Hatipoğlu ÇA, Cesur S, Bulut C et al.Addison hastalığı ile renal tüberküloz birlikteliği. Turk J Clin Lab 2019; 10: 262-264 2519 2679 W2808438167.pdf 0 31 separator 0.99069035 ¶ 2679 2681 W2808438167.pdf 0 0 paratext 0.98198575 "International Journal of Engineering and Advanced Technology (IJEAT) ISSN: 2249 – 8958 (Onl ine), Volume -9 Issue -5, June 2020" 0 133 W3201008129.pdf 2 1 separator 0.53185725 134 135 W3201008129.pdf 2 2 paratext 0.9633257 "¶ 265 Published By: Blue Eyes Intelligence Engineering & Sciences Publication © Copyr ight: All rights reserved. Retrieval Number: E9467069520 /2020©BEIESP DOI: 10.35940/ijeat. E9467 .069520 Journal Website: www.ijeat.org" 135 380 W3201008129.pdf 2 3 separator 0.9934093 ¶ 382 384 W3201008129.pdf 2 4 text 0.9995145 "This method gives voltage stability in provisos of a parameter called loading margin. Loading margin is the maximum allowable load increase from the base load condition before the model enters voltage collapse. CPF also gives the wide -ranging PV cu rve of the grid buses. CPF is a precise approach for speculating the maximum loading limit and purposed the “weakest bus” When the voltage collapse happens . Simulation and it is done by using (PSAT). Several steps have been achieved the objectives, the ste p used to simulate the bus system." 385 964 W3201008129.pdf 2 5 separator 0.9814792 ¶ 966 968 W3201008129.pdf 2 6 text 0.984406 "a) Modeling the bus system by using PSAT b) Implement the PF analysis (NR method). c) Execute the CPF and draw PV curve to find weak bus of the model d) Observe the convenient placement of FACTS devices , so it gives best execution . e) Obtained the voltage value at all buses and real power losses with and without using FACTS for OPF studies." 968 1347 W3201008129.pdf 2 7 separator 0.99726427 ¶ 1349 1351 W3201008129.pdf 2 8 title 0.9933591 V. V. CASES OF STUDY 1351 1373 W3201008129.pdf 2 9 separator 0.9961678 ¶ 1375 1377 W3201008129.pdf 2 10 text 0.99959743 "In this model IEEE 39 bus is get congested when connecting excess loads on the buses 7, 16,3,12. The weakest bus of the grid a t over loading condition and has minimum voltage proportion has been identified bus 7 . So, this bus is the optimal place for FACTS devices. “So the small signal stability will be check by using Eigen values and tabulate the Eigen values with the positive o r zero values with its dominant state ”." 1377 1831 W3201008129.pdf 2 11 separator 0.9973767 ¶ 1832 1834 W3201008129.pdf 2 12 title 0.9926547 A. Small Signal Stability Analysis 1834 1869 W3201008129.pdf 2 13 separator 0.9959042 ¶ 1871 1873 W3201008129.pdf 2 14 text 0.9996492 "After the time domain simulation the Eigen values analyses are calculated for over loading condition. The results are shown in the table (II). This observes the system is in unstable condition due to overloading disturbance occur and no FACTS device connected because the positive Eigen values are exist. Connecting FACTS devices in the suitable place (bus 7 and line 7 -6 best Line for shunt compensation ) from the sensitivity based eigen v alue analysis a small signal stability is improved. The Results for applying FACTS device are tabulated, from the results the positive eigens are reduced from 1 to 0 and negative eigens are increased. So the network is maintained stable by using FACTS devi ces.”" 1873 2628 W3201008129.pdf 2 15 separator 0.9840511 ¶ ¶ 2629 2635 W3201008129.pdf 2 16 caption 0.97102046 "Fig. 3. Computed Eigen values of case for Overloaded condition without FACTS" 2635 2715 W3201008129.pdf 2 17 separator 0.9939564 ¶ 2717 2719 W3201008129.pdf 2 18 text 0.9994605 "As shown from figure (3) for IEEE 39 bus when over loaded condition without FACTS devices. The model has 110 Eigen numbers, all Eigen numbers are negative exce pt the Eigen number (λ 21) is positive value and λ98 is zero Eigen value in this case, so the model is unstable." 2719 3007 W3201008129.pdf 2 19 separator 0.9565454 ¶ ¶ 3009 3015 W3201008129.pdf 2 20 caption 0.99463165 "Fig. 4. Computed Eigen values of case for Overloaded condition and with SVC" 3015 3094 W3201008129.pdf 2 21 separator 0.8974494 ¶ ¶ 3096 3102 W3201008129.pdf 2 22 caption 0.9949314 "Fig. 5. Computed Eigen values of case for Overloaded condition and with STATCOM" 3102 3185 W3201008129.pdf 2 23 separator 0.794537 ¶ ¶ 3187 3193 W3201008129.pdf 2 24 caption 0.99572664 "Fig. 6. Computed “Eigen values ” of case for Overloaded condition and with SSSC" 3193 3276 W3201008129.pdf 2 0 text 0.9978364 "binding to the integrin bcytoplasmic domain, a final step in integrin activation. Here we analyzed mice bearing mutations in one or both of the Rap1-binding sites of talin-1 and used these mice to de fine the connection between Rap1 and talin-1 in platelets. Compared with the talin-1 F1 domain, the talin-1 F0 domain makes a relatively small contribution to integrin acti- vation in platelets. Disabling both Rap1-binding sites had agreater effect than disabling F1 alone and recapitulated thedefect in integrin activation seen in platelets lacking both Rap1a and Rap1b. Thus, talin-1 is the principal and perhaps only platelet Rap1 effector for integrin activation; however, loss ofRap1 –talin-1 did not phenocopy defects in thrombocytopoiesis, secretion, and surface exposure of PS observed in Rap1- deficient platelets. These results combined with recent struc- tural studies suggest a mechanism whereby Rap1 mediates initial recruitment of talin-1 to the platelet membrane, resulting in unmasking of the talin-1 integrin-binding site and integrinactivation in hemostasis." 0 1099 W3033905875.pdf 7 1 separator 0.98893 ¶ 1099 1101 W3033905875.pdf 7 2 text 0.99893224 "Disabling the Rap1-binding sites in talin phenocopies lack of Rap1a and Rap1b with regard to platelet integrin activation andaggregation, indicating that talin-1 is a major Rap1 effector involved in these processes. Deletion of talin-1 itself had a slightly stronger effect, suggesting additional mechanisms,such as disruption of talin-1 autoinhibition by G a13, 31in talin- 1–dependent integrin activation. The fact that convulxin, which binds GPVI and signals via Syk tyrosine kinase, was slightly lessaffected suggests that tyrosine kinase signaling may provide another such alternative pathway. Interestingly, Rap1a/b-mKO mice exhibited a more profound hemostatic defect than Tln1-mR35E,R118E mice, even though integrin activation in plate- lets from these mice was impaired to a similar extent. This result can be ascribed to the mild thrombocytopenia and additionalplatelet function defects, such as impaired granule release andprocoagulant response, in mRap1a/b-KO mice. These added defects also highlight the potential importance of one of the many other known Rap1 effectors." 1101 2210 W3033905875.pdf 7 3 separator 0.98376477 ¶ 2210 2212 W3033905875.pdf 7 4 text 0.9918401 "32,33The defects in throm- bocytopoiesis and platelet morphology in mRap1a/b-KO mice raised the possibility that the def ective integrin activation, in part, could be due to a developmental defect in megakaryo-cytes rather than lack of Rap1 signaling in platelets. The presence of normal platelet counts, intact gross morphology, and secretion in Tln1-mR35E,R118 E platelets further indicates that Rap1 is the major final signaling element in platelet integrin activation." 2212 2698 W3033905875.pdf 7 5 separator 0.8289536 ¶ 2698 2700 W3033905875.pdf 7 6 text 0.9986237 "In combination with recent structural studies, 18the data reported here suggest a model for the main final steps in platelet integrin activation. Earlier work with talin-1 fragments in model systems showed that the talin-1 F3 domain alone is suf ficient for activation.34Even in the absence of Rap1 signaling, the presence of the lipid-binding sites in the F2 domain markedly increases the capacity of talin-1 to disrupt the integrin aand bsub- unit transmembrane domain interaction, resulting in integrin activation.35-38In contrast to these talin-1 fragments, full-length talin-1 is autoinhibited,39and this autoinhibition can be relieved by binding to phosphatidylinositol (4,5)-bisphosphate (PIP2).40In full-length talin-1, the integrin-binding site in F3 is obscured by its interaction with the R9 helical bundle of the rod domain,41-43 and a recent cryo-electron microscopic structure of talin-1revealed that the critical PIP2-binding site in F2 is masked by the R12 helical bundle" 2700 3716 W3033905875.pdf 7 7 separator 0.6184685 ¶ 3716 3718 W3033905875.pdf 7 8 text 0.8572168 18(Figure 6). The 3718 3736 W3033905875.pdf 7 9 table 0.45385957 talin-1 F0 and F1140Control Tln1-mR35E,R118E Rap1a/b-mKO 3736 3793 W3033905875.pdf 7 10 separator 0.8892199 ¶ 3793 3795 W3033905875.pdf 7 11 table 0.9930016 "******************ns nsns ns nsnsJonA/PE binding (MFI x100)120 100 80604020 75 125 PAR4-AP ( M)250 500 Veh.0A ***nsnsns ns nsns****** ****** ****** *** 50 100 Convulxin (ng/ml)200 400 Veh.JonA/PE binding (MFI x100)80 60 40 20 0B TimeAggregation (light transmitted)PAR4-AP ( M) Collagen ( g/ml) Control Tln1-mR35E,R118E Rap1a/b-mKO500 10 150 7.5 125 1 min 1 min2.5C" 3795 4207 W3033905875.pdf 7 12 separator 0.9762782 ¶ 4207 4209 W3033905875.pdf 7 13 caption 0.9949388 "Figure 4. Tln1-mR35E,R118E platelets exhibit impaired aIIbb3 activation to a similar extent as Rap1a/b-mKO platelets. (A-B) Flow cytometry assay to measure binding of GPIX-labeled platelets in whole blood to JonA/PE antibody in response toPAR4-AP (A) or convulxin (B) stimulation. Bar graphs represent mean fluorescence intensity (MFI) 6standard error of the mean (n 56 mice, representative of $3 independent experiments). (C) Representative aggregation responses of Tln1- mR35E,R118E and Rap1a/b-mKO platelets stimulated with various concentrations of agonists. Curves corresponding to control and Tln1-mR35E,R118E plateletsstimulated with PAR4-AP were from the same experiment as those depicted inFigure 3D. Arrows indicate addition of agonists. * P,.05;** P,.01; *** P,.001. ns, not signi ficant." 4209 5021 W3033905875.pdf 7 14 separator 0.98263127 ¶ 5021 5023 W3033905875.pdf 7 15 title 0.6415354 RAP1 –TALIN-1 BINDING CONTROLS PLATELET 5023 5063 W3033905875.pdf 7 16 paratext 0.5359786 5063 5064 W3033905875.pdf 7 17 title 0.5165898 AGG 5064 5067 W3033905875.pdf 7 18 paratext 0.9624982 REGATION blood® 3 SEPTEMBER 2020 | VOLUME 136, NUMBER 10 1187Downloaded from http://ashpublications.org/blood/article-pdf/136/10/1180/1756644/bloodbld2020005348.pdf by guest on 19 January 2022 5067 5259 W3033905875.pdf 7 19 separator 0.9937328 ¶ 5259 5261 W3033905875.pdf 7 0 title 0.98440903 Appendix F: Alkali Leaching Test 0 32 W4256253432.pdf 179 1 separator 0.99192166 ¶ 33 35 W4256253432.pdf 179 2 title 0.80891365 Leaching Results from the bottles with 0 25 mol/L solution 35 94 W4256253432.pdf 179 3 paratext 0.8200866 Continued on next 94 112 W4256253432.pdf 179 4 text 0.3947045 pa 112 115 W4256253432.pdf 179 5 paratext 0.52063864 ~ 115 116 W4256253432.pdf 179 6 title 0.38791883 e 116 117 W4256253432.pdf 179 7 paratext 0.8458216 . ... 117 123 W4256253432.pdf 179 8 separator 0.9903449 ¶ 124 126 W4256253432.pdf 179 9 paratext 0.346655 1 126 128 W4256253432.pdf 179 10 table 0.37875548 2 3 4 5 6 7 8 9 128 144 W4256253432.pdf 179 11 paratext 0.45158744 10 11 144 150 W4256253432.pdf 179 12 separator 0.9936764 ¶ 151 153 W4256253432.pdf 179 13 table 0.97507304 "Mix Initial Final Initial Final Na+ Difference in Difference in Difference in Difference in NazO e of #of K+ K+ Na+ ppm K+ Na+ K+ Na+ K+and moles of ppm ppm ppm concentration concentration concentration concentration Na+ NazO e ppm ppm moi/L mol/L mol/L control a 88.0 11.6 91.8 14.8 3.8 3.2 0.0097436 0.0139130 0.0118283 0.0001774 control b 88.0 11.6 93.2 14.0 5.2 2.4 0.0133333 0.0104348 0.0118841 0.0001783 control c 88.0 11.6 96.2 12.0 8.2 0.4 0.0210256 0.0017391 0.0113824 0.0001707 15/15 a 88.0 11.6 87.6 15.0 -0.4 3.4 -0.0010256 0.0147826 0.0068785 0.0001032 15115 b 88.0 11.6 91.4 13.0 3.4 1.4 0.0087179 0.0060870 0.0074025 0.0001110 15115 c 88.0 11.6 92.8 12.0 4.8 0.4 0.0123077 0.0017391 0.0070234 0.0001054 20/20 a 88.0 11.6 90.8 12.0 2.8 0.4 0.0071795 0.0017391 0.0044593 0.0000669 20/20 b 88.0 11.6 91 12.0 3.0 0.4 0.0076923 0.0017391 0.0047157 0.0000707 20/20 c 88.0 11.6 91.1 12.2 3.1 0.6 0.0079487 0.0026087 0.0052787 0.0000792 30/30 a 88.0 11.6 88.8 12.8 0.8 1.2 0.0020513 0.0052174 0.0036343 0.0000545 30/30 b 88.0 11.6 88.6 12.6 0.6 1.0 0.0015385 0.0043478 0.0029431 0.0000441 20 FA a 88.0 11.6 92.6 13.8 4.6 2.2 0.0117949 0.0095652 0.0106800 0.0001602 20FA b 88.0 11.6 92.4 13.4 4.4 1.8 0.0112821 0.0078261 0.0095541 0.0001433 20FAc 88.0 11.6 92.2 13.6 4.2 2.0 0.0107692 0.0086957 0.0097324 0.0001460 40Slag a 88.0 11.6 92.4 11.6 4.4 0.0 0.0112821 0.0000000 0.0056410 0.0000846 40Slag b 88.0 11.6 92.8 10.6 4.8 -1.0 0.0123077 -0.0043478 0.0039799 0.0000597" 153 1687 W4256253432.pdf 179 14 separator 0.89351773 ¶ 1688 1690 W4256253432.pdf 179 15 table 0.98547816 F-6 1690 1694 W4256253432.pdf 179 0 paratext 0.9332671 "JNMA I VOL 59 I ISSUE 242 I October 20211074 Free Full Text Articles are Available at www.jnma.com.npWAYS FORWARD" 0 115 W3208763591.pdf 2 1 separator 0.99469817 ¶ 116 118 W3208763591.pdf 2 2 text 0.998564 "Early clinical exposure is found to be beneficial wherever it has been practiced. Therefore experts from different countries have recommended the inclusion of Early clinical exposure in the medical curriculum including Nepal and India.14,15 But it is not free of limitations. It requires more resources, more time, more energy, proper training, and coordination among the faculties which can be overcome with the joint effort of faculties and students. Considering the fact that its necessities outweigh its limitations, it is high time that the ‘curriculum of yesterday’ be modified to teach the ‘physicians of tomorrow.’" 118 771 W3208763591.pdf 2 3 separator 0.9658324 ¶ 771 773 W3208763591.pdf 2 4 text 0.62639624 Conflict of Interest: None. 773 801 W3208763591.pdf 2 5 separator 0.9939421 ¶ 801 803 W3208763591.pdf 2 6 title 0.94421417 REFERENCES 803 814 W3208763591.pdf 2 7 separator 0.9900228 ¶ 814 816 W3208763591.pdf 2 8 bibliography 0.99707264 "1. Shah C. Early clinical exposure- Why and how? J Educ Technol Heal Sci. 2018;5(1):2–7. [ Full Text | DOI ]" 816 929 W3208763591.pdf 2 9 separator 0.6444314 ¶ 929 931 W3208763591.pdf 2 10 bibliography 0.984936 "2. Verma M. Early clinical exposure: New paradigm in Medical and Dental Education. Contemp Clin Dent. 2016;7(3):287–8. [PubMed | Full Text | DOI ]" 931 1086 W3208763591.pdf 2 11 separator 0.9850226 ¶ 1086 1088 W3208763591.pdf 2 12 bibliography 0.7622992 "3. Curriculum for Bachelor of Medicine & Bachelor of Surgery Tribhuvan University Institute of Medicine. Revised in 2008 published by" 1088 1228 W3208763591.pdf 2 13 contact 0.42733774 National 1228 1237 W3208763591.pdf 2 14 bibliography 0.56753397 "Centre for Health Professions Education," 1237 1281 W3208763591.pdf 2 15 contact 0.4519584 Institute 1281 1291 W3208763591.pdf 2 16 bibliography 0.5410419 of Medicine, 1291 1304 W3208763591.pdf 2 17 contact 0.4635883 Maharajgunj 1304 1316 W3208763591.pdf 2 18 bibliography 0.49115315 , K 1316 1319 W3208763591.pdf 2 19 contact 0.39920703 athmandu 1319 1327 W3208763591.pdf 2 20 bibliography 0.8696542 ", Nepal. [ Full Text ]" 1327 1352 W3208763591.pdf 2 21 separator 0.95519865 ¶ 1352 1354 W3208763591.pdf 2 22 bibliography 0.99740094 "4. Medical Council of India. Early Clinical Exposure for Undergraduate Medical Education Training Program, 2019: pp 1-43. [ Full Text ]" 1354 1496 W3208763591.pdf 2 23 separator 0.954136 ¶ 1496 1498 W3208763591.pdf 2 24 bibliography 0.99741834 "5. Lakshmi NR, Dharwadkar AA, Mohanty S, Gayatri N, Vadapalli K. Perception of 1st year MBBS students on Early Clinical Exposure with Horizontal Integration as a teaching Learning method. Journal of Basic and Clinical Research. 2016;3(1):10-17. [ Full Text ]" 1498 1769 W3208763591.pdf 2 25 separator 0.9332802 ¶ 1769 1771 W3208763591.pdf 2 26 bibliography 0.9968888 "6. Choudhary A, Gupta V. Teaching communications skills to medical students: Introducing the fine art of medical practice. Int J Appl Basic Med Res. 2015;5(4):41. [ PubMed | Full Text | DOI ]" 1771 1974 W3208763591.pdf 2 27 separator 0.9663018 ¶ 1974 1976 W3208763591.pdf 2 28 bibliography 0.99747 "7. Tayade MC, Bhimani N, Kulkarni NB, Dandekar KN. The impact of Early Clinical Exposure on First M . B . B . S . Students. International J. of Healthcare and Biomedical Research. 2014;2(4):176-181. [ Full Text ]" 1976 2198 W3208763591.pdf 2 29 separator 0.9549628 ¶ 2198 2200 W3208763591.pdf 2 30 bibliography 0.99076164 "8. Rawekar A, Jagzape A, Srivastava T, Gotarkar S. Skill learning through early clinical exposure: An experience of Indian medical school. J Clin Diagnostic Res. 2016;10(1):JC01– " 2200 2386 W3208763591.pdf 2 31 separator 0.6540323 ¶ 2386 2387 W3208763591.pdf 2 32 bibliography 0.9973278 "4. [PubMed | Full Text | DOI ]9. Ghosh S, Dawka V. Combination of didactic lecture with problem-based learning sessions in physiology teaching in a developing medical college in Nepal. Am J Physiol - Adv Physiol Educ. 2000;24(1):8–12. [ PubMed | Full Text | DOI ]" 2387 2664 W3208763591.pdf 2 33 separator 0.9738221 ¶ 2664 2666 W3208763591.pdf 2 34 bibliography 0.98892796 "10. DAS P, Biswas S, Singh R, Mukherjee S, Ghoshal S, Pramanik D. Effectiveness of early clinical exposure in learning respiratory physiology among the newly entrant MBBS students. J Adv Med Educ Prof [Internet]. 2017;5(1):6–10. [PubMed | Full Text ]" 2666 2930 W3208763591.pdf 2 35 separator 0.9739844 ¶ 2930 2932 W3208763591.pdf 2 36 bibliography 0.9856881 "11. Başak O, Yaphe J, Spiegel W, Wilm S, Carelli F, Metsemakers JFM. Early clinical exposure in medical curricula across Europe: An overview. Eur J Gen Pract. 2009;15(1):4–10. [PubMed | Full Text | DOI ]" 2932 3147 W3208763591.pdf 2 37 separator 0.9706063 ¶ 3147 3149 W3208763591.pdf 2 38 bibliography 0.99752843 "12. Granek L, Lazarev I, Birenstock-Cohen S, Geffen DB, Riesenberg K, Ariad S. Early exposure to a clinical oncology course during the preclinical second year of medical school. Acad Med. 2015;90(4):454–7. [ PubMed | Full Text | DOI ]" 3149 3395 W3208763591.pdf 2 39 separator 0.96347183 ¶ 3395 3397 W3208763591.pdf 2 40 bibliography 0.99773663 "13. Sathishkumar S, Thomas N, Tharion E, Neelakantan N, Vyas R. Attitude of medical students towards Early Clinical Exposure in learning endocrine physiology. BMC Med Educ. 2007;7:1–7. [ PubMed | Full Text | DOI ]" 3397 3622 W3208763591.pdf 2 41 separator 0.94558144 ¶ 3622 3624 W3208763591.pdf 2 42 bibliography 0.99717003 "14. Saiyad S, Saiyad M, Pandya C. Implementation of cardiopulmonary resuscitation workshop in first MBBS. Int J Appl Basic Med Res. 2015;5(4):11. [ PubMed | Full Text | DOI ]" 3624 3810 W3208763591.pdf 2 43 separator 0.975626 ¶ 3810 3812 W3208763591.pdf 2 44 bibliography 0.99737275 "15. Piryani RM, Shankar PR, Thapa TP, Karki BM, Kafle RK, Khakurel MP, et al. Introduction of structured physical examination skills to second year undergraduate medical students. F1000Research. 2013;2:1–13. [ PubMed | Full Text ]Basukala et al. Early Clinical Exposure in Preclinical Years of Medical School" 3812 4132 W3208763591.pdf 2 45 separator 0.78993225 ¶ 4132 4134 W3208763591.pdf 2 46 paratext 0.8898435 © The Author(s) 2018. 4134 4156 W3208763591.pdf 2 47 separator 0.9570733 ¶ 4158 4160 W3208763591.pdf 2 48 paratext 0.9212175 "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/" 4160 4653 W3208763591.pdf 2 0 text 0.989739 "Table 4. The distribution of the HL subtypes was: 4 (23.5%) nodular lymphocyt e-predominant Hodgkin lymphoma (NLPHL), 1 (5.9%) lymphocyte rich clas- sical Hodgkin lymphoma (LRCHL), 10 (58.8%) of mixed cellularity classical Hodgkin lymphoma (MCCH L) and 2 (11.8%) nodular sclerosis classical Hodgkin lymphoma (NSCHL). EBV infection was noticed in 6 cases of MCCHL. Following IHC and expert revision, 10 cases (71%) out of 14 of the DLBCL group pre- sented a discordant diagnosis (Supplementary Table 3)." 0 520 W3165554536.pdf 4 1 separator 0.81083477 ¶ 520 522 W3165554536.pdf 4 2 text 0.9968786 "Instead, all the BL cases showed a concordant diagno- sis in 2 cases (40%) and the rest were discordant (n= 3; 60%), as shown in Supplementary Table 4. For t h eI g b oe t h n i cg r o u p ,t h e r ew a sa ni d e n t i c a ldistribution in the number of CLL (33.3%), DLBCL, NOS (33.3%), and HL/HD (33.3%) as presented in Table 4." 522 862 W3165554536.pdf 4 3 separator 0.9787573 ¶ 862 864 W3165554536.pdf 4 4 text 0.9975391 "The histologic diagnosis of the remaining 6 entities (Supplementary Table 5) were discordant with the final diagnosis according to the latest WHO classifica- tion: 2 SMZL (3%), 1 ENMZL (1.5%), 1 (1.5%) follicu- lar lymphoma (FL), 1 LPL (1.5%), 1 (1.5%) B- lymphoblastic leukemia/ lymphoma (B-LBL) and 1 (1.5%) Angioimmunoblastic T-cell lymphoma (AITL)." 864 1229 W3165554536.pdf 4 5 separator 0.80889225 ¶ 1229 1231 W3165554536.pdf 4 6 text 0.98995775 "The representative slides of the H&E and IHC are s h o w ni nF i g s . 3,4and 5." 1231 1314 W3165554536.pdf 4 7 separator 0.99679375 ¶ 1314 1316 W3165554536.pdf 4 8 title 0.99120617 "Revised diagnosis of rare conditions and non-lymphoid neoplasm" 1316 1381 W3165554536.pdf 4 9 separator 0.992736 ¶ 1381 1383 W3165554536.pdf 4 10 text 0.9992305 "The non-lymphoid malignancies and other rare condi- tions that were more accurately diagnosed using IHC are shown in Supplementary Table 6. Apart from the identified rare conditions such as Castleman Disease (n= 2; 14.3%), Rosai Dorfman Disease (n = 2; 14.3%), the rest of the cases were metastases of carcinomas ( n=6 ; 43%) and sarcomas ( n= 4; 28.6%)." 1383 1750 W3165554536.pdf 4 11 separator 0.99717075 ¶ 1750 1752 W3165554536.pdf 4 12 title 0.98802894 Cell of origin (COO) 1752 1773 W3165554536.pdf 4 13 separator 0.99333215 ¶ 1773 1775 W3165554536.pdf 4 14 text 0.9994331 "The COO determined by the Hans algorithm demon- strated that 10 (71.4%) cases were of the Germinal Cen- ter type (GCB), 3 (21.4%) were Non-Germinal Centre (non-GCB) type, and 1 (7.1%) case could not be deter- mined (Supplementary Table 3). Also, in both GCB and non-GCB subtypes, two of the DLBCL, NOS (14.3%), presented co-expression of c-MYC protein and BCL2 (“double expressors ”)." 1775 2174 W3165554536.pdf 4 15 separator 0.99664474 ¶ 2174 2176 W3165554536.pdf 4 16 title 0.9861363 "Frequency of Epstein-Barr-virus in the lymphoma subtypes" 2176 2235 W3165554536.pdf 4 17 separator 0.9768497 ¶ 2235 2237 W3165554536.pdf 4 18 text 0.999392 "EBV was observed only in 10 cases (15.2%): 6 HL (60%), 3 BL (30%), and one case of DLBCL, EBV+. All the EBV positive cases of HL were MCCHL. The association be- tween the presence of EBV and lymphoid neoplasm sub- types was statistically significant ( p= 0.023)." 2237 2508 W3165554536.pdf 4 19 separator 0.9969375 ¶ 2508 2510 W3165554536.pdf 4 20 title 0.97731036 Discussion 2510 2521 W3165554536.pdf 4 21 separator 0.99097645 ¶ 2521 2523 W3165554536.pdf 4 22 text 0.9949972 "Detailed immunohistochemical characterization is needed to achieve a precise diagnosis to guarantee an" 2523 2628 W3165554536.pdf 4 23 title 0.9729986 Table 3 List of antibodies used 2628 2659 W3165554536.pdf 4 24 separator 0.8874285 ¶ 2659 2661 W3165554536.pdf 4 25 table 0.98697054 "ANTIBODY COMPANY CLONE DILUTION Bcl-2 Roche Ventana SP66 ready to use Bcl-6 Cell Marque GI191E/A8 1:50 CD 10 Roche Ventana SP67 ready to use CD 138 Roche Ventana B-A38 ready to use CD 15 Roche Ventana MMA ready to use CD 20 Roche Ventana L-26 ready to use CD 21 Roche Ventana 2G9 ready to use CD 23 Roche Ventana SP23 ready to use CD 3 Roche Ventana 2GV6 ready to use CICLINA D Roche Ventana SP4-R ready to use C-MYC Roche Ventana EP121 ready to use HHV8 Roche Ventana 13B10 ready to use KAPPA Cell Marque L1C1 1:20 KI-67 Roche Ventana 30 9 ready to use LAMBDA Cell Marque LAMB14 1:50 IGA Cell Marque 2652 1:50 IGG Cell Marque 2653 1:50 IGM Cell Marque 2654 1:50 PAX5 Roche Ventana SP34 ready to use PD-1 Cell Marque NAT105 1:20 S-100 Roche Ventana 4C4.9 ready to use TDT Cell Marque TDT 1:100" 2661 3499 W3165554536.pdf 4 26 separator 0.99658835 ¶ 3499 3501 W3165554536.pdf 4 27 title 0.9717938 Table 4 Lymphoid neoplasm distribution in different population in Nigeria 3501 3575 W3165554536.pdf 4 28 separator 0.8902768 ¶ 3575 3577 W3165554536.pdf 4 29 table 0.9932909 "TOTAL (66)CLL (23) HL (17)DLBCL, NOS (14) BL (5)SMZL (2) ENMZL (1) B-LBL (1) AITL (1) FL (1)LPL (1) Hausa/MHCL (n= 59)29 (43.9%) 15 (65.2%) 5 (29.4%) 7 (50%) 2 (40%) 0 0 0 0 0 0 Igbo/ESUTH (n= 46)9 (13.6%) 3 (13%) 3 (17.6%) 3 (21.4%) 0 0 0 0 0 0 0 Yoruba/UCH (n= 47)28 (42.4%) 5 (21.7%) 9 (52.4%) 4 (28.6%) 3 (60%) 2 (100%) 1 (100%) 1 (100%) 1 (100%) 1 (100%) 1 (100%)Uz" 3577 3970 W3165554536.pdf 4 30 paratext 0.36126208 oma 3970 3973 W3165554536.pdf 4 31 table 0.56399226 et al 3973 3979 W3165554536.pdf 4 32 paratext 0.950081 . Infectious Agents and Cancer (2021) 16:36 Page 5 of 11 3979 4045 W3165554536.pdf 4 0 paratext 0.9851803 www.ccsenet.org/gjhs Global Journal of Health Science V ol. 2, No. 2; October 2010 0 114 W2037959334.pdf 6 1 separator 0.72527665 ¶ 115 117 W2037959334.pdf 6 2 paratext 0.9718025 Published by Canadian Center of Science and Education 231 117 175 W2037959334.pdf 6 3 separator 0.8040844 "¶ ¶ ¶" 176 194 W2037959334.pdf 6 4 caption 0.9933669 Figure 1. Amount of blood loss and duration of menstrual cycle 194 257 W2037959334.pdf 6 5 separator 0.93553054 "¶ ¶ ¶" 258 276 W2037959334.pdf 6 0 text 0.96648467 "In order to simplify the model and facilitate solution, dimensionless variables are first introduced:" 0 102 W4221045748.pdf 2 1 separator 0.9870559 ¶ 102 104 W4221045748.pdf 2 2 math 0.74848455 p1fD=K1fhpi−p1f/C16/C17 104 128 W4221045748.pdf 2 3 separator 0.42348647 ¶ 128 130 W4221045748.pdf 2 4 text 0.93841344 "1:842 × 10−3qBμ, ð1Þ where p1fDis the dimensionless fracture pressure in the inner zone, k1fis the fracture permeability in the inner zone, his the e ffective stratum thickness, piis the initial formation pressure, p1fis the fracture pressure in the inner zone, qis the ground yield, Bis the crude oil volume factor, and μis the crude oil viscosity." 130 491 W4221045748.pdf 2 5 separator 0.9615149 ¶ 491 493 W4221045748.pdf 2 6 math 0.63158256 "p1mD=K1fhpi−p1m ðÞ 1:842 × 10−3" 493 527 W4221045748.pdf 2 7 text 0.43313327 q 527 528 W4221045748.pdf 2 8 math 0.44712695 Bμ, 528 531 W4221045748.pdf 2 9 text 0.44952506 531 532 W4221045748.pdf 2 10 math 0.46745542 ð2Þ 532 535 W4221045748.pdf 2 11 text 0.8221106 ¶ where p1mDis the dimensionless matrix pressure in the innerzone and p1mis the matrix pressure in the inner zone. 535 650 W4221045748.pdf 2 12 separator 0.85425776 ¶ 650 652 W4221045748.pdf 2 13 math 0.67580485 p2fD=K1fhpi−p2f/C16/C17 ¶ 652 678 W4221045748.pdf 2 14 text 0.807964 "1:842 × 10−3qBμ, ð3Þ where p2fDis the dimensionless fracture pressure in the outer zone, k2fis the fracture permeability in the outer zone, andp2fis the fracture pressure in the outer zone." 678 874 W4221045748.pdf 2 15 separator 0.9265407 ¶ 874 876 W4221045748.pdf 2 16 math 0.6066665 "p2mD=K1fhpi−p2m ðÞ 1:842 × 10−3" 876 910 W4221045748.pdf 2 17 text 0.42622823 q 910 911 W4221045748.pdf 2 18 math 0.42979833 B 911 912 W4221045748.pdf 2 19 text 0.44922164 μ, 912 915 W4221045748.pdf 2 20 math 0.472922 ð4Þ 915 918 W4221045748.pdf 2 21 text 0.7768435 "¶ where p2mDis the dimensionless matrix pressure in the outer zone and p2mis the matrix pressure in the outer zone." 918 1036 W4221045748.pdf 2 22 separator 0.870613 ¶ 1036 1038 W4221045748.pdf 2 23 math 0.63407004 "pwfD=K1fhpi−pwf/C16/C17 1:842 × 10−" 1038 1076 W4221045748.pdf 2 24 text 0.45490313 3qBμ, ð 1076 1083 W4221045748.pdf 2 25 math 0.47820818 5Þ 1083 1085 W4221045748.pdf 2 26 text 0.78489244 "¶ where pwfDis the dimensionless wellbore flow pressure and pwfis the wellbore flow pressure." 1085 1179 W4221045748.pdf 2 27 separator 0.95508206 ¶ 1179 1181 W4221045748.pdf 2 28 math 0.64641356 "tD=3:6K1ft φVCt ðÞ1μrw2, ð6Þ" 1181 1212 W4221045748.pdf 2 29 text 0.90009034 "¶ where tDis the dimensionless time, tis time, rwis the well- bore radius, and ðφVCtÞ1is the product of porosity, reser- voir volume, and comprehensive elastic compressibility of the inner zone." 1212 1413 W4221045748.pdf 2 30 separator 0.8897578 ¶ 1413 1415 W4221045748.pdf 2 31 math 0.62672037 "CD=0:156C 2πφVCt ðÞ1hrw2, ð7Þ ¶" 1415 1449 W4221045748.pdf 2 32 text 0.7528113 where CDis the dimensionless wellbore storage factor and C 1449 1508 W4221045748.pdf 2 33 math 0.8583121 "0.010.1110log pw/p′w log tD/CD log PwD log P′wD1E+01 1E+02 1E+03 1E+04 1E+05 1E+06 1E+07 1E+08" 1508 1609 W4221045748.pdf 2 34 separator 0.9937064 ¶ 1609 1611 W4221045748.pdf 2 35 caption 0.9947943 Figure 3: Theoretical double logarithm characteristic curve of dual-media composite reservoir model. 1611 1712 W4221045748.pdf 2 36 separator 0.99560094 ¶ 1712 1714 W4221045748.pdf 2 37 title 0.97417146 Table 1: basic parameter table. 1714 1746 W4221045748.pdf 2 38 separator 0.9929286 ¶ 1746 1748 W4221045748.pdf 2 39 table 0.9503347 "Formation parameters Result k1(mD) 4 ω1 0.05 λ1 2×1 0−5 k2(mD) 3.6 ω2 0.05 λ2 5:6×1 0−6 C(m3/MPa) 3 S -5.7 R(m) 30 pi(MPa) 50 h(m) 380 q(m3/d)" 1748 1915 W4221045748.pdf 2 40 paratext 0.93464744 2003 Geofluids 1915 1929 W4221045748.pdf 2 0 paratext 0.9886478 Developmental Cognitive Neuroscience 25 (2017) 105–112 0 57 W2595009824.pdf 0 1 separator 0.935101 ¶ 57 59 W2595009824.pdf 0 2 title 0.8263626 Contents lists available at ScienceDirect 59 105 W2595009824.pdf 0 3 paratext 0.4758251 105 106 W2595009824.pdf 0 4 separator 0.49846253 ¶ 106 107 W2595009824.pdf 0 5 paratext 0.5676509 "Developmental Cognitive Neuroscience j o ur nal ho me" 107 170 W2595009824.pdf 0 6 text 0.38578323 pa 171 174 W2595009824.pdf 0 7 paratext 0.62019354 ge: http://www.elsevier.com/locate/dcn 175 215 W2595009824.pdf 0 8 separator 0.9886445 ¶ 215 217 W2595009824.pdf 0 9 title 0.98002815 "Attention allocation and social worries predict interpretations of peer-related social cues in adolescents" 217 334 W2595009824.pdf 0 10 separator 0.9936278 ¶ 334 336 W2595009824.pdf 0 11 contact 0.6244224 Simone 336 343 W2595009824.pdf 0 12 bibliography 0.54160994 P. 344 347 W2595009824.pdf 0 13 contact 0.51268697 W 347 348 W2595009824.pdf 0 14 bibliography 0.62293345 . 348 349 W2595009824.pdf 0 15 contact 0.62821436 Hallera 350 358 W2595009824.pdf 0 16 bibliography 0.4956803 , 358 359 W2595009824.pdf 0 17 contact 0.6202179 ∗, Brianna R 359 373 W2595009824.pdf 0 18 bibliography 0.52485204 . 373 374 W2595009824.pdf 0 19 contact 0.6516428 "Dohertya, Mihaela Dutaa, Kathrin Cohen Kadosha,c, Jennifer Y.F" 375 445 W2595009824.pdf 0 20 bibliography 0.4920265 . 445 446 W2595009824.pdf 0 21 contact 0.7754744 Laub, Gaia Scerifa 447 468 W2595009824.pdf 0 22 separator 0.5455566 468 469 W2595009824.pdf 0 23 contact 0.98266846 "¶ aDepartment of Experimental Psychology, University of Oxford, Oxford, United Kingdom bInstitute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom cSchool of Psychology, University of Surrey, Surrey, United Kingdom" 469 752 W2595009824.pdf 0 24 separator 0.9752752 ¶ 752 754 W2595009824.pdf 0 25 title 0.97897863 a r t i c l e i n f o 754 785 W2595009824.pdf 0 26 separator 0.7637577 ¶ 785 787 W2595009824.pdf 0 27 title 0.8176177 Article history: 787 804 W2595009824.pdf 0 28 separator 0.90331703 ¶ 804 806 W2595009824.pdf 0 29 paratext 0.60828024 "Received 18 June 2016 Received in revised form 14 March 2017 Accepted 14 March 2017 Available online 18 March 2017" 806 946 W2595009824.pdf 0 30 separator 0.99367046 ¶ 946 948 W2595009824.pdf 0 31 title 0.9304746 "Keywords:AdolescenceSocial anxiety Eye tracking" 948 1001 W2595009824.pdf 0 32 separator 0.55490124 ¶ 1001 1003 W2595009824.pdf 0 33 title 0.9900342 AttentionAppraisalInterpretationa b s t r a c t 1003 1058 W2595009824.pdf 0 34 separator 0.992601 ¶ 1058 1060 W2595009824.pdf 0 35 text 0.99508905 "Adolescence is a sensitive period for increases in normative but also debilitating social fears and worries. As the interpretation of interpersonal cues is pertinent to social anxiety, investigating mechanisms that may underlie biases in social cue appraisal is important." 1060 1371 W2595009824.pdf 0 36 separator 0.6834625 ¶ 1371 1373 W2595009824.pdf 0 37 text 0.9992334 "Fifty-one adolescents from the community aged 14–19 were presented with self- and other-relevant naturalistic social scenes for 5 s and then required to rate either a negative or a positive interpreta- tion of the scene. Eye-tracking data were collected during the free viewing period to index attentional deployment. Individual differences in social worries were measured via self-report." 1373 1818 W2595009824.pdf 0 38 separator 0.890528 ¶ 1818 1820 W2595009824.pdf 0 39 text 0.9940586 "Social anxiety levels significantly predicted biases in interpretation ratings across scenes. Additionally, cumulative attentional deployment to peer cues also predicted these interpretation biases: participants who spent more time on facial displays perceived more threat, i.e. endorsed more negative and less positive interpretations. Self-relevant scenes yielded greater tendencies to draw negative interpretations. Finally, older adolescents also selected more benign interpretations." 1820 2365 W2595009824.pdf 0 40 separator 0.7849606 ¶ 2365 2367 W2595009824.pdf 0 41 text 0.99922705 "Social anxiety is associated with a bias in interpreting social cues; a cognitive bias that is also influ- enced by attentional deployment. This study contributes to our understanding of the possible attention mechanisms that shape cognitions relevant to social anxiety in this at-risk age group." 2367 2706 W2595009824.pdf 0 42 separator 0.93247014 ¶ 2706 2708 W2595009824.pdf 0 43 paratext 0.9823881 "© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ )." 2708 2877 W2595009824.pdf 0 44 separator 0.99031967 ¶ 2877 2879 W2595009824.pdf 0 45 title 0.98595184 1. Introduction 2879 2896 W2595009824.pdf 0 46 separator 0.9949192 ¶ 2896 2898 W2595009824.pdf 0 47 text 0.9983344 "Social interactions are central to well-being across the life span, with different relationships (e.g., caregivers, peers, romantic relations) taking center stage at different developmental periods (Nelson et al., 2016 ). In adolescence, peers become increasingly important (Steinberg and Silverberg, 1986 ). Given increased affec- tive and motivational value of specifically peer-related social cues during this period, it is perhaps not surprising that normative social anxiety and self-consciousness increase (Miers et al., 2014; Westenberg et al., 2004 ). Age-of-onset data further suggests that adolescence is a developmentally sensitive juncture for the emer- gence of more impairing, clinical levels of social fears and worries. These tend to persist and account for a significant proportion of adult Social Anxiety Disorder (SAD; e.g., Kessler et al., 2005 )." 2898 3895 W2595009824.pdf 0 48 separator 0.9891351 ¶ 3895 3897 W2595009824.pdf 0 49 contact 0.9952186 "∗Corresponding author. E-mail address: simona.haller@gmail.com (S.P.W. Haller)" 3897 3981 W2595009824.pdf 0 50 title 0.99265796 .1.1. Cognitive biases and social anxiety 3981 4027 W2595009824.pdf 0 51 separator 0.99530536 ¶ 4027 4029 W2595009824.pdf 0 52 text 0.999623 "Social interactions require the attention to and interpretation of complex and dynamic visual and verbal, often individual-specific indicators of others’ mental states. Preferential allocation of atten- tion to socially threatening cues (e.g, faces or words) and negative interpretations of ambiguous social cues (e.g., a frown, a pause in a conversation, a smile) have been linked to social fears and worries in youths (e.g., Muris and Field, 2008 ). These biases are thought to shape experiences of the social world and maintain fears by increasing perceived negative social feedback (Clark and Wells, 1995; Rapee and Heimberg, 1997 ). Biases in the interpretation of social-evaluative situations are targeted in treatment approaches such as Cognitive Behavioural Therapy." 4029 4925 W2595009824.pdf 0 53 separator 0.7826115 ¶ 4925 4927 W2595009824.pdf 0 54 text 0.9994654 "Surprisingly little is known about the mechanisms underlying disproportional social threat perception – how biases in one or more central cognitive processes result in a skewed representation of the social world. Biases have been suggested to permeate early to late stages of information processing (Musa and Lépine, 2000 ), with interactive effects on emotional responding (Hirsch et al., 2006 ). It" 4927 5391 W2595009824.pdf 0 55 separator 0.86577404 ¶ 5391 5393 W2595009824.pdf 0 56 paratext 0.7489259 https://doi.org/10.1016/ 5393 5418 W2595009824.pdf 0 57 text 0.56107694 j 5418 5419 W2595009824.pdf 0 58 paratext 0.65949136 . 5419 5420 W2595009824.pdf 0 59 text 0.5691493 dcn 5420 5423 W2595009824.pdf 0 60 paratext 0.8987714 .2017.03.004 5423 5435 W2595009824.pdf 0 61 separator 0.8708695 ¶ 5435 5437 W2595009824.pdf 0 62 paratext 0.9840288 1878-9293/© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ). 5437 5615 W2595009824.pdf 0 0 paratext 0.89514637 Citation 0 8 W4394686042.pdf 0 1 bibliography 0.9727491 ": Nita, N.; Tadic, M.; Mörike, J.; Paukovitsch, M.; Felbel, D.; Keßler, M.; Gröger, M.; Schneider, L.-M.; Rottbauer, W." 8 133 W4394686042.pdf 0 2 paratext 0.7432955 Long- 133 139 W4394686042.pdf 0 3 title 0.7451311 "Term Mortality after Transcatheter Edge-to-Edge Mitral Valve Repair Significantly Decreased over" 139 241 W4394686042.pdf 0 4 paratext 0.4903685 the 241 245 W4394686042.pdf 0 5 title 0.52250755 Last 245 250 W4394686042.pdf 0 6 paratext 0.62896293 Decade: 250 258 W4394686042.pdf 0 7 separator 0.77417624 ¶ 258 260 W4394686042.pdf 0 8 paratext 0.9390105 "Comparison between Initial and Current Experience from the MiTra Ulm Registry. J. Clin. Med. 2024 ,13, 2172. https://doi.org/10.3390/ jcm13082172" 260 414 W4394686042.pdf 0 9 separator 0.8802938 ¶ 414 416 W4394686042.pdf 0 10 paratext 0.7777469 Academic Editor: 416 433 W4394686042.pdf 0 11 contact 0.5658918 Tomasz Tokarek 433 448 W4394686042.pdf 0 12 paratext 0.95749927 "¶ Received: 11 March 2024 Revised: 1 April 2024 Accepted: 5 April 2024 Published: 10 April 2024" 448 550 W4394686042.pdf 0 13 separator 0.56064963 ¶ 550 552 W4394686042.pdf 0 14 paratext 0.93773943 "Copyright: ©2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). Journal of Clinical Medicine ¶" 552 853 W4394686042.pdf 0 15 title 0.8758542 Article 853 861 W4394686042.pdf 0 16 separator 0.57154834 ¶ 861 863 W4394686042.pdf 0 17 title 0.98112303 "Long-Term Mortality after Transcatheter Edge-to-Edge Mitral Valve Repair Significantly Decreased over the Last Decade:" 863 984 W4394686042.pdf 0 18 separator 0.6006018 ¶ 984 986 W4394686042.pdf 0 19 title 0.9782796 "Comparison between Initial and Current Experience from the MiTra Ulm Registry" 986 1066 W4394686042.pdf 0 20 separator 0.9928738 ¶ 1066 1068 W4394686042.pdf 0 21 contact 0.988777 "Nicoleta Nita *, Marijana Tadic , Johannes Mörike, Michael Paukovitsch, Dominik Felbel , Mirjam Keßler , Matthias Gröger , Leonhard-Moritz Schneider and Wolfgang Rottbauer Department of Internal Medicine II, University Medical Center, 89081 Ulm, Germany; marijana.tadic@uniklinik-ulm.de (M.T.); johannes.moerike@uniklinik-ulm.de (J.M.); michael.paukovitsch@uniklinik-ulm.de (M.P .); dominik.felbel@uniklinik-ulm.de (D.F.); mirjam.kessler@uniklinik-ulm.de (M.K.); matthias.groeger@uniklinik-ulm.de (M.G.); leonhard-moritz.schneider@uniklinik-ulm.de (L.-M.S.); wolfgang.rottbauer@uniklinik-ulm.de (W.R.) " 1068 1695 W4394686042.pdf 0 22 separator 0.61618423 ¶ 1695 1696 W4394686042.pdf 0 23 contact 0.9971339 *Correspondence: nicoleta.nita@uniklinik-ulm.de 1696 1744 W4394686042.pdf 0 24 separator 0.9954047 ¶ 1744 1746 W4394686042.pdf 0 25 text 0.99897987 "Abstract: (1)Objective : We aimed to assess whether the candidate profile, the long-term outcomes and the predictors for long-term mortality after transcatheter edge-to-edge mitral valve repair (M- TEER) have changed over the last decade; (2) Methods : Long-term follow-up data (median time of 1202 days) including mortality, MACCE and functional status were available for 677 consecutive patients enrolled in the prospective MiTra Ulm registry from January 2010 to April 2019. The initial 340 patients treated in our institution before January 2016 were compared with the following 337 patients ; (3) Results : Patients treated after 2016 showed significantly less ventricular dilatation (left ventricular end-systolic diameter of 43 ±13 mm vs. 49 ±16 mm, p< 0.007), lower systolic pulmonary pressures (50 ±15 mmHg vs. 57 ±21 mmHg, p= 0.01) and a lower prevalence of severe tricuspid regurgitation (27.2% vs. 47.3%, p< 0.001) at baseline than patients treated before 2016. Compared to the cohort treated before 2016, patients treated afterwards showed a significantly lower all-cause 3-year mortality (29.4% vs. 43.8%, p< 0.001) and lower MACCE (38.6% vs. 54.1%, p< 0.001 ), without differences for MR etiology. While severe tricuspid regurgitation and NYHA class IV remained independently associated with an increased long-term mortality over the last decade, severe left ventricular dilatation (hazard ratio, HR 2.12, p= 0.047) and severe pulmonary hypertension (HR 2.18, p= 0.047) were predictors of long-term mortality only in patients treated before 2016. (4) Conclusions : The M-TEER candidates are currently treated earlier in the course of disease and benefit significantly in terms of a better long-term survival than patients treated at the beginning of the M-TEER era." 1746 3563 W4394686042.pdf 0 26 separator 0.98009205 ¶ 3563 3565 W4394686042.pdf 0 27 text 0.5590313 Keywords: M-TEER long-term outcome; survival trends after M-TEER; prospective register M-TEER 3565 3659 W4394686042.pdf 0 28 separator 0.996523 ¶ 3659 3661 W4394686042.pdf 0 29 title 0.9815271 1. Introduction 3661 3677 W4394686042.pdf 0 30 separator 0.99597013 ¶ 3677 3679 W4394686042.pdf 0 31 text 0.9993006 "Over the past decade, transcatheter mitral edge-to-edge repair (M-TEER) has revolu- tionized the management of inoperable patients suffering from severe mitral regurgitation (MR). Improvements in heart failure symptoms, quality of life and short-term survival have been documented in several trials [ 1–4], leading to increasing recognition and acceptance of M-TEER in recent European and American guidelines for both primary and secondary MR [ 5]." 3679 4136 W4394686042.pdf 0 32 separator 0.6147676 ¶ 4136 4138 W4394686042.pdf 0 33 text 0.9995703 "However, discrepant data have been reported in recent years regarding long-term outcomes after the procedure, with long-term mortality rates at three to four years ranging from 17% in the Everest II trial to 53% in the German TRAMI registry [ 6,7]. The largest trials in this field, the COAPT trial and MITRA-FR trial, revealed divergent mid-term cardiovascular outcomes in functional MR; however, the latest long-term follow-up results" 4138 4583 W4394686042.pdf 0 34 separator 0.93939734 ¶ 4583 4585 W4394686042.pdf 0 35 paratext 0.97928435 J. Clin. Med. 2024 ,13, 2172. https://doi.org/10.3390/jcm13082172 https://www.mdpi.com/journal/jcm 4585 4684 W4394686042.pdf 0 0 paratext 0.83160734 Case 15 Liu 0 11 W2594541205.pdf 13 1 bibliography 0.6953007 , X. F. 11 18 W2594541205.pdf 13 2 paratext 0.61742616 (2014). RETRACTED: Substitution reactions of diiron 18 70 W2594541205.pdf 13 3 bibliography 0.7394699 "dithiolate complexes with phosphine or isocyanide ligands. Journal of Organometallic Chemistry,750," 70 172 W2594541205.pdf 13 4 paratext 0.58692276 117–124. 172 181 W2594541205.pdf 13 5 separator 0.9957769 ¶ 181 183 W2594541205.pdf 13 6 text 0.9975591 "This article was retracted in 2014, due to plagiarism which not only pertained to the text but also to the methodology presented. The editor in chief states in the retraction notice thatthe‘‘some of the work reported as new in this paper, was previously conducted by someone else...the...method used and the proposed mechanism ...are similar to those previously reported [previously by someone else] and ...portions of the manuscript are worded identically to those in manuscripts that have been published’’ (retraction notice). As can be seen from the statement, this article presents deep and compound case of plagiarism thatranges from text to methods. Yet it is still positively cited, with 12 citations in 2015: 9positive and 3 neutral. Since the article was retracted in the same year as it was published,3" 183 998 W2594541205.pdf 13 7 table 0.95033944 "8 7 10 7 7 8 8 9 2 024681012 " 998 1040 W2594541205.pdf 13 8 separator 0.5392334 ¶ 1040 1041 W2594541205.pdf 13 9 table 0.8698505 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016Number of cita/g415ons 1041 1113 W2594541205.pdf 13 10 separator 0.98614234 ¶ 1114 1116 W2594541205.pdf 13 11 caption 0.8086726 Fig. 16 Number of citations per year—Liu et al. article 1116 1172 W2594541205.pdf 13 12 table 0.9421028 "¶ 5 22 25 19 9 12 4 051015202530 2010 2011 2012 2013 2014 2015 2016Number of cita/g415ons" 1172 1276 W2594541205.pdf 13 13 separator 0.969239 ¶ 1277 1279 W2594541205.pdf 13 14 caption 0.97134316 Fig. 17 Number of citations by year—Nabae et al. article560 Scientometrics (2017) 113:547–565 1279 1373 W2594541205.pdf 13 15 separator 0.9914416 ¶ 1373 1375 W2594541205.pdf 13 16 paratext 0.7480857 123 1375 1379 W2594541205.pdf 13 0 title 0.9428066 "Effects of ceiling fan and window exhaust on aerosol transmission risk during home quarantine situation" 0 106 W4380992211.pdf 0 1 separator 0.9293957 ¶ 108 110 W4380992211.pdf 0 2 contact 0.7246179 Toby Cheung1* and Kwok Wai Tham1 110 145 W4380992211.pdf 0 3 separator 0.59318614 ¶ 146 148 W4380992211.pdf 0 4 contact 0.9017591 1 Department of the Built Environment, National University of Singapore, Singapore 148 231 W4380992211.pdf 0 5 separator 0.9943869 ¶ 233 235 W4380992211.pdf 0 6 text 0.9994655 "Abstract . SARS -CoV-2 has been recognized to be airborne transmissible. With the increased transmissibility leading to increasingly reported positive cases, home quarantine is adopted for the infected patients who are not seriously ill. However, the risk of household aerosol transmission is not well studied. We conducted tracer gas experiment to simulate the exhaled virus laden aerosols from a patient under home quarantine situation inside a residential testbed. The Sulphur hexafluoride concentration (SF 6,conc ) was measured both inside and outside the quarantine room under various scenarios including, (i) air-conditioning (AC) vs natural ventilation (NV), (ii) operation of ceiling fan, and (iii) operation of window exhaust fan. The ratio of outside -to-inside SF 6,conc (O/I SF6) was an indicator for potential expo sure of occupants in the same household. Our findings showed, without an exhaust fan, the in -room SF 6,conc in AC settings was 4 times higher than in the NV scenarios. Meanwhile, we found the exhaust fan was effective in reducing the O/I SF6 in the AC scenarios (with or without ceiling fan), but its function was diminished in the NV setting with ceiling fan. We suspected the effectiveness of exhaust fan was reduced by air infiltration from other window openings in NV situation. Meanwhile, the operation of ceiling fan continuously pushing tracer gas outwards from the quarantine room through the door gap. Our results suggested that natural ventilation with windows open or switching on a window exhaust fan could reduce aerosol transmission risk from the quarantine room. This study provides useful evidence in recommending low risk ventilation strategies for home quarantine situations ." 235 2015 W4380992211.pdf 0 7 separator 0.9968157 ¶ 2017 2019 W4380992211.pdf 0 8 title 0.98274505 1 Introduction 2019 2034 W4380992211.pdf 0 9 separator 0.99500906 ¶ 2036 2038 W4380992211.pdf 0 10 text 0.99951935 "It has been 3 years since the outbreak of Coronavirus disease 2019 (COVID 19). Thanks for the vaccine development, our lives are slowly getting back to normal. Governments and health authorities started recommending the infected patients with non -severe symptoms be self -isolated at home instead of quarantining in hospital and isolation facilities [ 1]." 2038 2414 W4380992211.pdf 0 11 separator 0.76620746 ¶ 2415 2417 W4380992211.pdf 0 12 text 0.9996629 "However, residential facilities are not designed to serve quarantine purpose, even though the infected person is staying in an isolated bedroom, airborne viruses could have escaped outside. It is of even higher concern for those newer variants that are m ore transmissible (e.g., Omicron variant) [2] meaning that it only needs a small amount of the virus leakage from the quarantine room to potentially infect other family members living in the same house ." 2417 2900 W4380992211.pdf 0 13 separator 0.97294104 ¶ 2902 2904 W4380992211.pdf 0 14 text 0.99960136 "The intra-house transmission of the aerosols in a residential house is mainly from the leakages through the gaps between the door and its frame or the floor. The operating strategy of the isolation room, such as the settings of the air conditioning (AC), the fan, and the window operating status, plays a par ticularly vital role in terms of the airborne pollutant transmission across the door [3, 4]. An opened window [5] or ventilating fan [6] can enhance air exchange rate in diluting in -room" 2904 3427 W4380992211.pdf 0 15 separator 0.9362041 ¶ ¶ 3428 3434 W4380992211.pdf 0 16 contact 0.9897168 * Corresponding author: toby_bdg@nus.edu.sg 3434 3479 W4380992211.pdf 0 17 text 0.99933684 "aerosol concentration, but the airborne transmission across the door the other space within the house remains unknown. A normal operating ceiling fan tends to move air downward under the blades coverage area and further pushes the air along the floor level [ 7]. Provided that doors in residential buildings are normally not w ell sealed (i.e., a larger gap between door and floor), ceiling fan operation may enhance the possibility of aerosol leakage even when the door is closed. Apart from the aerosol leakage via door gap, aerosol transmission is possible through some necessary door-opening activities, such as food delivery and trash removal. The impact of the door -opening activity on the aerosol transmission between spaces has been well studied in healthcare facilities [3] and pressurized clean room [ 8]." 3480 4340 W4380992211.pdf 0 18 separator 0.8697329 ¶ 4341 4343 W4380992211.pdf 0 19 text 0.9994479 "However, there is no rep orted study focusing on the impact of the door opening on aerosol transmission in a residential facility ." 4343 4481 W4380992211.pdf 0 20 separator 0.87546074 ¶ 4482 4484 W4380992211.pdf 0 21 text 0.99948215 "The tracer gas methods are widely used to experimentally study the pathogen airborne transmission risk due to its reliability and repeatability charac teristics [ 9, 10 ]. Among the potential tracer gas choices, sulphur hexafluoride (SF 6) is the most used gas because of its detectability at low concentrations , low toxicity, and scarcity in the background environment [11, 12 ]." 4484 4889 W4380992211.pdf 0 22 paratext 0.9715169 "E3S Web of Conferences 396, 02006 (2023) https://doi.org/10.1051/e3sconf/202339602006 IAQVEC2023 © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http ://creativecommons.org/licenses/by/4.0/)." 4889 5195 W4380992211.pdf 0 23 separator 0.7068917 5195 5196 W4380992211.pdf 0 24 paratext 0.83368826 s 5196 5197 W4380992211.pdf 0 0 paratext 0.9763407 Open Peer Review on Qeios 0 25 W4233665173.pdf 0 1 separator 0.60511315 ¶ 25 27 W4233665173.pdf 0 2 paratext 0.9320063 Open Peer Review on Qeios 27 53 W4233665173.pdf 0 3 separator 0.95276016 ¶ 53 55 W4233665173.pdf 0 4 title 0.98471844 Vascular Endothelial Growth Factor 55 90 W4233665173.pdf 0 5 separator 0.8372539 ¶ 90 92 W4233665173.pdf 0 6 title 0.9747807 Receptor 92 101 W4233665173.pdf 0 7 separator 0.9817077 ¶ 101 103 W4233665173.pdf 0 8 title 0.73762965 National Cancer Institute 103 129 W4233665173.pdf 0 9 separator 0.9557073 ¶ 129 131 W4233665173.pdf 0 10 paratext 0.49903876 Source 131 138 W4233665173.pdf 0 11 separator 0.9040904 ¶ 138 140 W4233665173.pdf 0 12 paratext 0.40281457 National Cancer Institute. 140 167 W4233665173.pdf 0 13 separator 0.9795047 ¶ 168 170 W4233665173.pdf 0 14 title 0.5629505 Vascular Endothelial 170 191 W4233665173.pdf 0 15 paratext 0.3437956 191 192 W4233665173.pdf 0 16 title 0.4396976 Growth Factor Receptor 192 214 W4233665173.pdf 0 17 separator 0.4655944 ¶ 214 217 W4233665173.pdf 0 18 paratext 0.45632902 . NCI Thesaurus. 217 233 W4233665173.pdf 0 19 separator 0.39386308 ¶ 233 235 W4233665173.pdf 0 20 paratext 0.4170994 Code C17293. 235 248 W4233665173.pdf 0 21 separator 0.99364376 ¶ 248 250 W4233665173.pdf 0 22 text 0.9995048 "There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF- D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor." 250 990 W4233665173.pdf 0 23 separator 0.9805131 ¶ 990 992 W4233665173.pdf 0 24 paratext 0.9384686 "Qeios · Definition, February 2, 2020 Qeios ID: FX399C · https://doi.org/10.32388/FX399C 1 /" 992 1101 W4233665173.pdf 0 25 separator 0.62033594 ¶ 1101 1103 W4233665173.pdf 0 26 paratext 0.8623154 1 1103 1105 W4233665173.pdf 0 0 paratext 0.9779966 Open Peer Review on Qeios 0 25 W4252285596.pdf 0 1 separator 0.7210753 ¶ 25 27 W4252285596.pdf 0 2 paratext 0.929972 Open Peer Review on Qeios 27 53 W4252285596.pdf 0 3 separator 0.96532714 ¶ 53 55 W4252285596.pdf 0 4 title 0.98374736 Outer Cannula Device 55 76 W4252285596.pdf 0 5 separator 0.98085785 ¶ 76 78 W4252285596.pdf 0 6 paratext 0.46737698 National 78 87 W4252285596.pdf 0 7 title 0.40336704 Cancer Institute 87 104 W4252285596.pdf 0 8 separator 0.9248625 ¶ 104 106 W4252285596.pdf 0 9 paratext 0.5517045 Source 106 113 W4252285596.pdf 0 10 separator 0.76476485 ¶ 113 115 W4252285596.pdf 0 11 paratext 0.3905933 National Cancer Institute. 115 142 W4252285596.pdf 0 12 separator 0.9798901 ¶ 143 145 W4252285596.pdf 0 13 title 0.9171168 Outer Cannula Device 145 166 W4252285596.pdf 0 14 separator 0.7795247 ¶ 166 168 W4252285596.pdf 0 15 bibliography 0.38778937 . N 168 172 W4252285596.pdf 0 16 paratext 0.36913148 CI 172 174 W4252285596.pdf 0 17 bibliography 0.43328556 Thesaurus. Code C49860. 174 198 W4252285596.pdf 0 18 separator 0.9879949 ¶ 198 200 W4252285596.pdf 0 19 text 0.9603034 The outer component of a double-cannula device, designed to be indwelling. 200 275 W4252285596.pdf 0 20 separator 0.97782826 ¶ 275 277 W4252285596.pdf 0 21 paratext 0.93317294 "Qeios · Definition, February 7, 2020" 277 321 W4252285596.pdf 0 22 separator 0.6457292 321 322 W4252285596.pdf 0 23 paratext 0.9582483 ¶ Qeios ID: ZZY5MB · https://doi.org/10.32388/ZZY5MB 322 378 W4252285596.pdf 0 24 separator 0.49204502 378 379 W4252285596.pdf 0 25 paratext 0.8802634 "¶ 1 /" 379 386 W4252285596.pdf 0 26 separator 0.85810775 ¶ 386 388 W4252285596.pdf 0 27 paratext 0.5160802 1 388 390 W4252285596.pdf 0 0 paratext 0.9898946 Page 16/21 0 10 W4210675554.pdf 15 1 separator 0.9963186 ¶ 10 12 W4210675554.pdf 15 2 caption 0.8101497 Figure 1 12 21 W4210675554.pdf 15 3 separator 0.9908388 ¶ 21 23 W4210675554.pdf 15 4 caption 0.9894032 "(a) TEM image of as-prepared CD; (b) Particle size distribution map of as-prepared CD; (c) XRD patterns of as-prepared CD; (d) Fourier transform infrared spectrogram of as-prepared CD." 23 210 W4210675554.pdf 15 0 paratext 0.98189104 Tatsu moto et al.: Historical Transitions of Eco-Stru cture TheScientificW orldJOURNAL (2004) 4, 315 –323 0 106 W2101981716.pdf 1 1 separator 0.9845346 ¶ ¶ 106 112 W2101981716.pdf 1 2 title 0.98655254 INTRODUCTION 112 125 W2101981716.pdf 1 3 separator 0.99489963 ¶ 126 128 W2101981716.pdf 1 4 text 0.9997407 "A tidal flat i s, generally , located in a boundar y zone between land and sea. Th e environm ental factors are therefore, drastically changed with periodic charact eristics of tide action and fresh water su pplied from rivers. The growth rate of algae, such a s diatoms and/or flagellums for ming biofilm on the surface of the sediment lay er, is kept at a very high level because of the continuit y nutrient salt suppl y from areas, land, and sea. Then, the diversit y according t o floristic co mposition, namely the tida l food chain ecosy stem , is established in the area by the addition of feed for fish a nd birds. O n the other ha nd, the tidal f lat is a very important pla ce for hum an living as s ymbiosis betw een hum an living an d natu ral environment. Althou gh the area h as been decrea sed by the rec lamation of s hallow sea with a view to expanding the econo mical field, it has b een recently recognized that the tidal flat as a wetland is important for the key area of the natural food chain. The “Convention on Wetlands (R amsar Iran, 1971)”, whose purpose is t o preserve a migratory area, was adapte d by the International Unio n for Conserv ation of Nature and Natural Resources (IUCN) in 1971. Thirteen wetland areas in Japan were registered for the conven tion at the en d of 2 002." 128 1485 W2101981716.pdf 1 5 separator 0.9894937 ¶ 1486 1488 W2101981716.pdf 1 6 text 0.9996985 "Yatsu tidal flat, which was registered u nder the Convention on Wetlands in June 1993 , is located in the urban coastal zone of Toky o Ba y, as shown in Fig. 1, and has an extre mely unique process on the transition of t idal function, includin g tidal geom orphic developme nt. The tidal flat had a characteristi c of vast foreshore ty pe observed at the front of the coastline in Tokyo Bay until 1971, i.e., until about 30 years before. After the reclam ation works, the utili zation t ype of sur roundi ng shoreline was ch anged fro m fishery and in timacy of water areas to industrial and r esidential areas. Yatsu tidal flat (area: 40.1 ha) was finally left alone in shallo w seawater and its water shoreline distorted into a lagoon-t ype ti dal flat in shape, by concrete shore pr otections[1,2 ]." 1488 2323 W2101981716.pdf 1 7 separator 0.98771465 ¶ ¶ 2324 2330 W2101981716.pdf 1 8 caption 0.9887085 FIGU RE 1 . Location of Yatsu tidal flat and sam pling sites. 2330 2392 W2101981716.pdf 1 9 separator 0.99425316 ¶ 2394 2396 W2101981716.pdf 1 10 text 0.99932367 "The Yatsu tidal flat has been utilized as an eating and resting space f or migratory birds, which m ove a long distance between Siberia in the Fa r Eastern Are a and Australia in the Southern He misphere every year. For this reason, the Yatsu tidal flat was regi stered under the Convention on Wetlands in June 199 3." 2396 2724 W2101981716.pdf 1 11 separator 0.9207349 ¶ 2725 2727 W2101981716.pdf 1 12 text 0.9983015 "A decrease of macrobenthos as food for migratory birds was caused by a decrease of mud sediment areas with organic matter inflowing from the surroundi ng area. The sig nificance of the existence of the Yatsu" 2727 2942 W2101981716.pdf 1 13 separator 0.94087887 ¶ 2944 2946 W2101981716.pdf 1 14 paratext 0.96164167 316 2947 2951 W2101981716.pdf 1 0 paratext 0.9897981  e-ISSN :2597 -7156 – p-ISSN: 2502-7786 0 41 W4323365426.pdf 1 1 separator 0.62632644 ¶ 42 44 W4323365426.pdf 1 2 paratext 0.97575176 Jurnal Ilmiah Perekam dan Informasi Kesehatan Imelda , Vol. 8, No. 1, Februari 2023:1-8 2 44 136 W4323365426.pdf 1 3 separator 0.9944296 ¶ 137 139 W4323365426.pdf 1 4 text 0.9781392 "terkait adalah dengan adanya penyelenggaraan rekam medis yang se suai dengan standar yang berlaku [1]." 139 246 W4323365426.pdf 1 5 separator 0.94892335 ¶ 247 249 W4323365426.pdf 1 6 text 0.99878407 "Berdasarkan PERMENKES RI No. 269 Tahun 2008 tentang Rekam Medis, menyebutkan bahwa, Rekam Medis adalah berkas yang berisikan dokumen dan catatan tentang identitas pasien, pemeriksaan, pengobatan, tindakan serta pelayanan lain yang telah diberikan fasilitas pelayanan kesehatan kepada pasien. Rekam Medis juga harus dibuat secara tertulis, lengkap dan jelas secara elektronik, sehingga dapat digunakan dalam perencanaan, pengolahan dan juga dapat digunakan untuk penelitian dalam kegiatan statistik pada fasilitas pelayanan kesehatan [2]." 249 806 W4323365426.pdf 1 7 separator 0.98224187 ¶ 808 810 W4323365426.pdf 1 8 text 0.99948126 "Penjajaran rek am medis merupakan pelaksanaan penataan rekam medis di rak ruang penyimpanan. Biasanya penjajaran rekam medis dilakukan secara manual maupun secara elektonik. Standarisasi sistem penjajaran di Indonesia saat ini menggunakan sistem terminal digit filing . Tujuan dari sistem penjajaran dan penyimpanan rekam medis adalah untuk mempermudah dan mempercepat ditemukannya kembali rekam medis yang telah tersusun pada rak penyimpanan. Penjajaran rekam medis juga sangat penting, karena jika hanya menyimpan rekam medis yang dimasukkan ke dalam rak tanpa menyusunnya, maka menyebabkan kesulitan dalam pencarian dan juga terjadinya keterlambatan waktu penyediaan rekam medis pasien [3]." 810 1534 W4323365426.pdf 1 9 separator 0.9752605 ¶ 1535 1537 W4323365426.pdf 1 10 text 0.9986687 "Pengambilan kembali rekam medis atau retrieval adalah kegiatan pengambilan rekam medis di rak penyimpanan untuk menunjang kegiatan pelayanan kesehatan." 1537 1693 W4323365426.pdf 1 11 separator 0.94210565 ¶ 1694 1696 W4323365426.pdf 1 12 text 0.999078 "Permintaan -permintaan rut in terhadap rekam medis yang datang dari poliklinik, dari dokter yang melakukan riset, harus dilanjutkan ke bagian rekam medis , setiap hari pada jam yang telah ditentukan. Pengambilan berkas rekam medis juga harus ditulis dalam buku register dan pada rak p enyimpanan diberi tracer sebagai penanda bahwa dokumen tersebut keluar [4]." 1696 2070 W4323365426.pdf 1 13 separator 0.98687947 ¶ 2071 2073 W4323365426.pdf 1 14 text 0.9971827 "Ketentuan peminjaman rekam medis merujuk pada PERMENKES RI No. 269 tahun 2008 tentang Rekam Medis, bahwa yang berhak meminjam rekam medis hanya dokter atau tenaga kesehatan lain yang merawat pasien. Secara umum peminjaman rekam medis dibagi menjadi 2 (dua) yaitu pinjaman rutin dan tidak rutin. Peminjaman rutin adalah peminjaman rekam medis oleh dokter atau tenaga kesehatan lain dikarenakan pasien yang memiliki berkas tersebut memerlukan atau sedang m endapatkan perawatan di unit pelayanan. Peminjaman tidak rutin adalah peminjaman rekam medis oleh tenaga kesehatan atau dokter untuk keperluan penelitian, makalah atau sejenisnya [5]." 2073 2735 W4323365426.pdf 1 15 separator 0.98335105 ¶ 2736 2738 W4323365426.pdf 1 16 text 0.99938875 "Rekam medis yang baik adalah salah satu keberhasilan manajemen dari suatu pelayanan, dengan itu penyimpanan rekam medis harus diatur sebai k mungkin agar dapat mempermudah petugas untuk mencari rekam medis yang diperlukan dan menghindari kesalahan dalam penyimpanan. Misfiled merupakan kesalahan dalam penempatan rekam medis, juga kesalahan dalam letak simpan, ataupun tidak ditemukannya rekam m edis di rak penyimpanan. Tingkat penyebab terjadinya misfiled disebabkan oleh beberapa faktor." 2738 3246 W4323365426.pdf 1 17 separator 0.7384803 ¶ 3247 3249 W4323365426.pdf 1 18 text 0.9992906 "Faktor yang dimaksud tersebut diantaranya, faktor sistem penyimpanan, faktor sistem penjajaran, faktor sistem penomoran, sarana di ruang penyimpan, serta faktor petugas ruang penyimpanan [6]." 3249 3448 W4323365426.pdf 1 19 separator 0.96158004 ¶ 3449 3451 W4323365426.pdf 1 20 text 0.99944717 "Dampak bila terjadinya misfiled pada pen jajaran rekam medis yaitu, akan terjadinya pertambahan waktu kerja bagi petugas dalam mencari suatu rekam medis pasien di rak ruang penyimpanan, mempersulit petugas dalam pencarian rekam medis yang bisa menyebabkan pembuatan rekam medis baru untuk pasien l ama, dan mengakibatkan penggandaan nomor rekam medis serta dapat menurunkan mutu pelayanan di rumah sakit karena pelayanan terhadap pasien jadi terhambat [7]." 3451 3926 W4323365426.pdf 1 21 separator 0.9941662 ¶ 3927 3929 W4323365426.pdf 1 22 text 0.96051615 Berdasarkan penelitian terdahulu oleh R ia Anggraeni tahun 2013 dengan judul 3929 4008 W4323365426.pdf 1 23 separator 0.51480687 ¶ 4008 4009 W4323365426.pdf 1 24 text 0.7057067 “Tinjauan Pengendalian Misfiled Dokumen Rekam Medis di Filing Rumah Sakit 4009 4085 W4323365426.pdf 1 0 paratext 0.98393196 INTERA ÇÕES, Campo Grande, MS, v. 22, n. 3, p. 1003-1020, jul./set. 20211006 0 77 W3209971751.pdf 3 1 separator 0.99102765 ¶ 79 81 W3209971751.pdf 3 2 bibliography 0.9661132 "Vanessa M. Hendler; Luciana D. de Oliveira; Martine E. K. Hagen; Andrea M. Solans; Queite M. S. da Silva; Louise B. Palma; Vanuska L. da Silva; Alessandro de O. Rios; Larissa M. Jucá Seabra; Eliziane N. F. Ruiz" 81 296 W3209971751.pdf 3 3 separator 0.9927683 ¶ 296 298 W3209971751.pdf 3 4 text 0.9995364 "Como forma de reconhecimento da diversidade biológica e sociocultural, além da PNPSB, foram criadas, na esfera federal, algumas iniciativas a fim de promover e fortalecer as cadeias de produtos da sociobiodiversidade, no âmbito dos mercados institucionais, como o PNAE. Em 2021, por exemplo, foi lançada a Portaria Interministerial MAPA/MMA n. 10 − atualizando a Portaria Interministerial n. 284, de 2018 –, a qual apresenta uma lista de produtos da sociobiodiversidade com potencial para serem incorporados em programas como o da Alimentação Escolar (BRASIL, 2018a; 2021). Ademais, para garantir condições justas de comercialização e viabilização de mercados, estabeleceu-se a Política de Garantia de Preços Mínimos para os Produtos da Sociobiodiversidade (PGPM-Bio), assegurando preços mínimos para mais de 17 produtos extrativistas (BRASIL, 2019)." 298 1173 W3209971751.pdf 3 5 separator 0.9804965 ¶ 1174 1176 W3209971751.pdf 3 6 text 0.9995574 "No âmbito internacional, destaca-se o projeto “Biodiversidade para Alimentação e Nutrição” – BFN, coordenado internacionalmente pelo Bioversity International (formalmente conhecido como Instituto Internacional de Recursos Genéticos Vegetais [IPGRI]), tendo como agências implementadoras o Programa das Nações Unidas para o Meio Ambiente (PNUMA) e a Organização das Nações Unidas para a Alimentação e a Agricultura (FAO). No Brasil, as atividades foram coordenadas pelo Ministério do Meio Ambiente em colaboração com diferentes setores do Governo Federal e parcerias realizadas junto a universidades e instituições de pesquisa de todo o país. Com o intuito de proporcionar o reconhecimento do valor alimentício e nutricional das espécies nativas brasileiras e visibilizar a possibilidade de intersecção em políticas públicas como o PNAE, o BFN construiu um banco de dados sobre a biodiversidade nacional, que reúne informações sobre composição nutricional, receitas, saberes tradicionais e mapeamento da distribuição geográfica de tais espécies (BRASIL, 2018b)." 1176 2270 W3209971751.pdf 3 7 separator 0.98768514 ¶ 2270 2272 W3209971751.pdf 3 8 text 0.99965274 "Na esfera regional, destaca-se, no Rio Grande do Sul (RS), as ações da Cadeia Solidária das Frutas Nativas (CSFN), que, enquanto uma rede, articula instituições ligadas à agroecologia e à economia solidária e atua com foco na valorização e difusão do consumo das frutas nativas do estado. As ações dessa rede ocorrem por meio de encontros e reuniões, nos quais discutem- se aspectos relacionados à produção, a custos, mercados, estratégias de comercialização, desenvolvimento de produtos, entre outras questões (RAMOS et al ., 2017)." 2272 2820 W3209971751.pdf 3 9 separator 0.984509 ¶ 2820 2822 W3209971751.pdf 3 10 text 0.99859977 "Seguindo essa ótica de fortalecer a relação entre sociobiodiversidade e alimentação escolar, vem sendo executado em esfera local, no município de Mostardas, localizado no Litoral Norte do Rio Grande do Sul, uma pesquisa-ação multicêntrica e interdisciplinar5, denominada “Alimentação adequada e saudável no contexto da alimentação escolar: difusão do consumo de produtos da sociobiodiversidade regional”. O projeto foi contemplado em edital do Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)/MCTIC N. 016/2016 e teve como foco trabalhar práticas de alimentação saudável em escolas por meio da inclusão de alimentos da sociobiodiversidade. O projeto compreende três etapas: 1) aproximação com a comunidade e desenvolvimento da oficina culinária; 2) análise físico-química de alimentos da sociobiodiversidade; 3) aplicação de testes de adesão e aceitabilidade de preparações à base de alimentos da sociobiodiversidade nas escolas públicas do município de Mostardas." 2822 3839 W3209971751.pdf 3 11 separator 0.98844016 ¶ 3841 3843 W3209971751.pdf 3 12 text 0.99765724 "Para iniciar o projeto e prosseguir com o trabalho de inserção da sociobiodiversidade na alimentação escolar, foi necessário, então, abordar primeiramente questões como: quais" 3843 4022 W3209971751.pdf 3 13 separator 0.80876374 ¶ 5 4023 4027 W3209971751.pdf 3 14 text 0.91021603 "A pesquisa partiu da interface entre o campo da Nutrição com outros campos disciplinares, como da Antropologia, Biologia e o campo do Desenvolvimento Rural, que é interdisciplinar por natureza. Além disso, o projeto vem sendo executado em parceria com a Universidade Federal do Rio Grande do Norte (UFRN) e a Universidade de Buenos Aires (UBA), na Argentina." 4027 4395 W3209971751.pdf 3 0 paratext 0.88211536 BAYESIAN REGULARIZED DIF S10 0 28 W3192797421.pdf 9 1 separator 0.9896902 ¶ 28 30 W3192797421.pdf 9 2 math 0.7934643 "phi_age ~normal (0, LNprior ); phi_gen ~normal (0, LNprior ); phi_study ~normal (0, LNprior ); pi~beta (0.5 ,0.5); //The likelihood" 30 170 W3192797421.pdf 9 3 separator 0.45300955 ¶ 170 172 W3192797421.pdf 9 4 math 0.89903116 "for (j in 1:P){ Y[,j] ~bernoulli _logit (mu[,j]); } } " 172 233 W3192797421.pdf 9 5 separator 0.5344728 ¶ 233 234 W3192797421.pdf 9 6 math 0.80458355 """, verbose = T)" 234 250 W3192797421.pdf 9 7 separator 0.9952228 ¶ 250 252 W3192797421.pdf 9 8 title 0.99192816 Fitting and Diagnostics 252 276 W3192797421.pdf 9 9 separator 0.9958 ¶ 276 278 W3192797421.pdf 9 10 text 0.9989581 "The following code fit the successfully compiled model syntax from above. Things to note are that we need to manually indicate what parameter estimates to save. Here we did not save the Laplace shrinkage estimates. In addition, we experimented with the controloptions to ensure that no divergence occurred in our model fitting experience with this data. Among many reasons, divergence could occur because model is poorly identified, priors are chosen with inappropriate scales, or because model is complex. Increasing the control options here mostly helps with the last issue and needs to be re-examined when new data set or models are used. We could choose some model estimates to examine their diagnostics and determine reasons of potential divergence in the traceplot and pairs functions. More details can be found in the (Stan Development Team, 2019) reference guides." 278 1168 W3192797421.pdf 9 11 separator 0.9913268 ¶ 1168 1170 W3192797421.pdf 9 12 math 0.8823087 "stan _ssp <-sampling ( stan _m, data =fa.data , pars = c(""L"",""L _dif_age"",""L _dif_gen"",""L _dif_study "", ""nu"",""nu _dif_age"", ""nu_dif_gen "",""nu _dif_study "", ""mu_age "",""mu _gen"",""mu _study "",""mu _studyage ""," 1170 1386 W3192797421.pdf 9 0 paratext 0.98975825 Electronics 2019 ,8, 1532 3 of 16 0 33 W2995297826.pdf 2 1 separator 0.99525887 ¶ 33 35 W2995297826.pdf 2 2 text 0.9939441 "In the work of Lange et al. [ 12] an approach for landing and position control, similar to our work, was developed. Their approach was also based on OpenCV and on recognizing a landing pattern. However, their landing pattern was not built with the use of ArUco markers. In fact, the landing pattern used, with a diameter of 45 cm, was only detected from a distance of 70 cm. Therefore, this strategy cannot be used in an outdoor environment where the flight altitude is typically much higher. However, in this approach, the UAV does not need to see the entire marker, which is an advantage of this scheme." 35 652 W2995297826.pdf 2 3 separator 0.9608847 ¶ 652 654 W2995297826.pdf 2 4 text 0.99964845 "A system that can land on and track a slow moving vehicle (180 cm/s) was developed by Araar et al. [13]. Indoor experiments show that the UAV used was able to successfully land on the target landing platform (which also consists of multiple ArUco markers) from a height of approximately 80 cm." 654 954 W2995297826.pdf 2 5 separator 0.9670267 ¶ 954 956 W2995297826.pdf 2 6 text 0.999711 "More recently, Patruno et al. [ 14] presented a solution for the landing of UAVs on a human-made landing target. Their target was similar to traditional heliplatforms but with specific aspect ratios, so that it can be detected from long distances. The geometric properties of the H-shaped marks adopted are used to estimate the pose with high accuracy, achieving an average RMSE value of only 0.0137 m in pose and 1.04in orientation." 956 1398 W2995297826.pdf 2 7 separator 0.9884262 ¶ 1398 1400 W2995297826.pdf 2 8 text 0.999708 "Baca et al. [ 15] were able to detect a moving car at 15 km/h, predict its future movement and attach to it. To achieve it they equipped the UAV with onboard sensors and a computer, which detects the car using a monocular camera and predicts the car future movement using a nonlinear motion model. While following the car, the UAV lands on its roof and it attaches itself using magnetic legs." 1400 1799 W2995297826.pdf 2 9 separator 0.9790999 ¶ 1799 1801 W2995297826.pdf 2 10 text 0.9996749 "De Souza et al. [ 16] developed a autonomous landing system based on Artificial Neural Network (ANN) supervised by Fuzzy Mamdani Logic. Their method introduced low computational complexity while maintaining the characteristics and intelligence of the fuzzy logic controller. They validated their solution using both simulation and real tests for static and dynamic landing spots." 1801 2186 W2995297826.pdf 2 11 separator 0.9834577 ¶ 2186 2188 W2995297826.pdf 2 12 text 0.9997537 "Fraczek et al. [ 17] presented an embedded video system that allows the UAV to automatically detect safe landing sites. Their solution was implemented on a heterogeneous Zynq SoC device from Xilinx and a Jetson GPU. Differently from the previous works, this work does not rely on a human made marker. Through the use of machine learning and computer vision techniques, the UAV classifies the terrain into three classes. The proposed solution was tested on 100 test images and classified the different terrains correctly in 80% of the cases. Furthermore, in these tests the performance between the Zynq SoC device and the Jetson GPU was compared." 2188 2844 W2995297826.pdf 2 13 separator 0.9875113 ¶ 2844 2846 W2995297826.pdf 2 14 text 0.99972403 "Our work differs from the former ones as we want the UAV to detect the landing area when it is high above the ground (height >20 m) to compensate for possibly high GPS error values, while using cheap sensors (only a Raspberry Pi camera is needed) and yet still achieving very low errors in terms of landing accuracy ( <20 cm). To that extent, only one other source (the Ardupilot community [ 18]) was found that is attempting to achieve results similar to ours. Their method follows the same strategy as the work of Nowak et al. [ 10], as they also make use of an IR-beacon. According to the ArduPilot authors, their proposed method is able to land a UAV from an altitude of 15 m, reliably under all lighting conditions and with an maximum offset of only 30 cm. While the results of this approach are impressive, ours still outperforms it in terms of both accuracy, altitude and price." 2846 3748 W2995297826.pdf 2 15 separator 0.99655306 ¶ 3748 3750 W2995297826.pdf 2 16 title 0.99167895 3. Proposed Solution 3750 3771 W2995297826.pdf 2 17 separator 0.996632 ¶ 3771 3773 W2995297826.pdf 2 18 text 0.99974334 "The aim of this work is to make a UAV land on a specific location. First the UAV has to make a coarse approach to the landing zone. As stated before, the UAV will typically fail to hover above its exact target location, being usually within 1 to 3 m away from the intended landing position. Once the UAV is close to the target location our protocol is activated. The first step deals with finding the marker. The ArUco marker library [ 5,6] (based on OpenCV) provides a function which takes the camera feed and returns information about the marker(s). ArUco markers resemble the well-known QR-codes. They carry less information than the latter ones (only an id), which makes them easier to detect. A typical ArUco marker consists of a black border and a 6x6 square of black and white smaller" 3773 4576 W2995297826.pdf 2 0 paratext 0.98320585 Agro Ekonomi Vol. 2 4/No. 1 Juni 2014 0 38 W2252427117.pdf 4 1 separator 0.5802358 ¶ ¶ 86 92 W2252427117.pdf 4 2 paratext 0.9634376 98 92 95 W2252427117.pdf 4 3 title 0.9058179 d. Kesimpulan : 95 112 W2252427117.pdf 4 4 separator 0.9894755 ¶ 114 116 W2252427117.pdf 4 5 text 0.98699903 "Ho ditolak, Ha diterima : sebagian besar (≥50%) anggota kerlompok wanita tani memiliki motivasi yang tinggi dalam diversifikasi pangan lokal di Kabupaten Bantul. Berdasarkan hasil perhitungan menggunakan uji proporsi, didapatkan hasil bahwa Z hitung sebes ar 7,49 sedangkan Z tabel - 1,645 sehingga Ha diterima. Hal ini berarti sebagian besar anggota KWT memiliki motivasi yang tinggi dalam diversifikasi pangan lokal di Kabupaten Bantul." 116 588 W2252427117.pdf 4 6 separator 0.99305546 ¶ ¶ 590 596 W2252427117.pdf 4 7 title 0.93995523 "Faktor -Faktor yang Mempengaruhi Motvasi Anggota KWT Diversifikasi Pangan Lokal di Kabupaten Bantul" 596 703 W2252427117.pdf 4 8 separator 0.9811865 ¶ 705 707 W2252427117.pdf 4 9 text 0.9916023 "Motivasi anggota KWT dalam diversifikasi pangan lokal di Kabupaten Bantul diduga dipengaruhi oleh beberapa faktor, antara lain : umur, pendapatan, tingkat pendidikan, persepsi terhadap pangan lokal, keaktifan dalam penyuluhan, akses media massa serta harga beras. " 707 989 W2252427117.pdf 4 10 separator 0.53430724 ¶ 989 990 W2252427117.pdf 4 11 text 0.9979996 "Untuk mengetahui faktor yang berpengaruh nyata terhadap motivasi digunakan analisis regresi berganda dengan metode backward menggunaakan SPSS 17.00. Pada tahap awal ditampilkan hasil dari semua variabel independent kemudian secara bertahap variabel independent yang tidak berpengaruh secara nyata terhadap variabel dependent akan dihilangkan." 990 1355 W2252427117.pdf 4 12 separator 0.9969268 ¶ 1357 1359 W2252427117.pdf 4 13 title 0.8424038 Tabel 1. Hasil Analisis Regresi Faktor - 1359 1401 W2252427117.pdf 4 14 table 0.89028543 "Faktor yang diduga Mempengaruhi Motivasi Anggota KWT Variabel Koefisien Regresi T hit Sig. Harga beras 0,034 3,296 0.02* Keaktifan Penyuluhan 0,955 1,763 0,083* Konstanta 186,619 0,035 R Square 0,203 Ajusted R Square 0,175 F hitung 7,275 Ket : *) signifikansi α = 10% ns : Non signifikansi α = 10%" 1401 1767 W2252427117.pdf 4 15 separator 0.92775637 ¶ 1769 1771 W2252427117.pdf 4 16 paratext 0.59293956 Sumber: Analisis Data Primer, 2013 1771 1806 W2252427117.pdf 4 17 separator 0.9944837 ¶ 1808 1810 W2252427117.pdf 4 18 text 0.9948108 "Berdasarkan pengujian analisis regresi berganda, variabel dependent adalah motivasi (Y) dan variabel independent (X) meliputi faktor umur, pendapatan, tingkat pendidikan, persepsi terhadap pangan lokal, keaktifan dalam penyuluhan, akses media massa serta h arga beras." 1810 2091 W2252427117.pdf 4 19 separator 0.97497284 ¶ 2092 2094 W2252427117.pdf 4 20 text 0.87928843 "Hasil regresi berganda faktor -faktor yang mempengaruhi motivasi anggota KWT dalam diversifikasi pangan lokal di Kabupaten Bantul dapat dilihat pada tabel 1." 2094 2261 W2252427117.pdf 4 21 separator 0.9464888 ¶ 2263 2265 W2252427117.pdf 4 22 text 0.99142116 "Berdasarkan hasil analisis regresi linear berganda diatas, maka dapat disusun persamaa n regresi sebagai berikut :" 2265 2386 W2252427117.pdf 4 23 separator 0.8670118 ¶ 2388 2390 W2252427117.pdf 4 24 math 0.6947287 Y = -186,619+0,034 + 0,955 2390 2417 W2252427117.pdf 4 25 text 0.5615035 ¶ Keterangan : ¶ 2419 2438 W2252427117.pdf 4 26 table 0.42631033 Y 2438 2440 W2252427117.pdf 4 27 text 0.49670678 = Motivasi 2441 2452 W2252427117.pdf 4 28 table 0.48723605 anggota 2452 2460 W2252427117.pdf 4 29 text 0.4663119 K 2460 2462 W2252427117.pdf 4 30 table 0.4399367 WT 2462 2467 W2252427117.pdf 4 31 text 0.44847792 ¶ 2467 2468 W2252427117.pdf 4 32 table 0.4690402 X1 2468 2472 W2252427117.pdf 4 33 text 0.34935138 = 2472 2473 W2252427117.pdf 4 34 table 0.4735623 "Harga Beras X2 " 2473 2493 W2252427117.pdf 4 35 text 0.36924604 = 2493 2494 W2252427117.pdf 4 36 table 0.49956623 Keaktifan Penyuluhan 2494 2515 W2252427117.pdf 4 37 separator 0.96207374 ¶ 2517 2519 W2252427117.pdf 4 38 text 0.98475415 "Dari persamaan regresi berganda diatas dapat dijelaskan sebagai berikut :" 2519 2596 W2252427117.pdf 4 39 separator 0.87408954 ¶ 2598 2600 W2252427117.pdf 4 40 text 0.9912392 "a. Nilai adjusted R square (koefisien determinasi) merupakan salah satu kriteria penentu apakah suatu persamaan regresi tepat atau tidak. Nilai adjusted R square berada pada kisaran 0 -1, yang berarti semakin mendekati angka 1 maka model regresi tersebut semakin tepat. Berdasarkan ta bel 6.4 diketahui nilai adjusted R square sebesar 0,175 menunjukkan bahwa 17,5% variabel motivasi dapat dijelaskan oleh variabel harga beras dan keaktifan penyuluhan sedangkan 82,5% dijelaskan oleh variabel lain diluar model. " 2600 3151 W2252427117.pdf 4 41 separator 0.6173499 ¶ 3151 3152 W2252427117.pdf 4 42 text 0.9923334 "b. Nilai F adalah perbanding an antara rerata kuadrat dari regresi dengan rerata kuadrat residu. Berdasarkan analisis yang dilakukan, nilai F hitung adalah 7,275 dan F tabel 2,40. F hitung > F tabel menunjukkan bahwa variabel independent harga beras dan keaktifan penyuluhan secara ber sama -sama berpengaruh nyata terhadap motivasi anggota KWT." 3152 3520 W2252427117.pdf 4 43 separator 0.955676 ¶ 3522 3524 W2252427117.pdf 4 44 text 0.9707626 "Berikut ini akan dibahas hasil uji hipotesis masing -masing faktor yang berpengaruh nyata terhadap motivasi yang merupakan hasil anal isis regresi berganda (model 6) ." 3524 3701 W2252427117.pdf 4 45 separator 0.99688715 ¶ 3703 3705 W2252427117.pdf 4 46 title 0.98782265 1. Harga Beras 3705 3721 W2252427117.pdf 4 47 separator 0.9931884 ¶ 3723 3725 W2252427117.pdf 4 48 text 0.9955091 "Pada tabel 1 dapat dilihat koefisien regresi variabel harga beras yaitu sebesar 0,034 dengan nilai signifikansi 0,02 lebih kecil dari taraf signifikansi α=10%, T hitung 3,296 sedangkan t tabel 1,296. T hitung>T tabel sehingga hipotesis 3c diterima. Variabel harga bera s berpengaruh" 3725 4023 W2252427117.pdf 4 0 paratext 0.93009883 RESEARCH ARTICLE 0 16 W2473327186.pdf 0 1 separator 0.63883066 ¶ 16 18 W2473327186.pdf 0 2 paratext 0.6177267 "Electronic medical records in humanitarian emergencies – the development of an E" 21 105 W2473327186.pdf 0 3 title 0.51433104 bola clinical 105 118 W2473327186.pdf 0 4 paratext 0.8202899 "¶ information and patient management system [version 3; peer review: 2 approved]" 119 204 W2473327186.pdf 0 5 separator 0.991478 ¶ 204 206 W2473327186.pdf 0 6 contact 0.71169233 "Kiran Jobanputra1, Jane Greig1, Ganesh Shankar2, Eric Perakslis3, Ronald Kremer4, Jay Achar1, Ivan Gayton1" 206 316 W2473327186.pdf 0 7 separator 0.9756916 ¶ 316 318 W2473327186.pdf 0 8 contact 0.9814296 "1Manson Unit, Médecins sans Frontières (MSF), London, UK 2Google Crisis Response Team, Mountain View, CA, USA 3Centre for Biomedical Informatics and Department of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA, USA 4MSF, Amsterdam, The Netherlands" 318 624 W2473327186.pdf 0 9 separator 0.9550102 ¶ 626 628 W2473327186.pdf 0 10 paratext 0.9504612 "First published: 23 Jun 2016, 5:1477 https://doi.org/10.12688/f1000research.8287.1 Second version: 30 Sep 2016, 5:1477 https://doi.org/10.12688/f1000research.8287.2 Latest published: 23 Feb 2017, 5:1477 https://doi.org/10.12688/f1000research.8287.3v3" 628 898 W2473327186.pdf 0 11 separator 0.9879273 ¶ ¶ 898 904 W2473327186.pdf 0 12 title 0.9161924 Abstract 904 913 W2473327186.pdf 0 13 separator 0.9943197 ¶ 915 917 W2473327186.pdf 0 14 text 0.99915254 "By November 2015, the West Africa Ebola epidemic had caused 28598 infections and 11299 deaths in the three countries most affected. The outbreak required rapid innovation and adaptation. Médecins sans Frontières (MSF) scaled up its usual 20-30 bed Ebola management centres (EMCs) to 100-300 beds with over 300 workers in some settings. This brought challenges in patient and clinical data management resulting from the difficulties of working safely with high numbers of Ebola patients. We describe a project MSF established with software developers and the Google Social Impact Team to develop context-adapted tools to address the challenges of recording Ebola clinical information. We share the outcomes and key lessons learned in innovating rapidly under pressure in difficult environmental conditions. Information on adoption, maintenance, and data quality was gathered through review of project documentation, discussions with field staff and key project stakeholders, and analysis of tablet data. In March 2015, a full prototype was deployed in Magburaka EMC, Sierra Leone. Inpatient data were captured on 204 clinical interactions with 34 patients from 5 March until 10 April 2015. Data continued to also be recorded on paper charts, creating theoretically identical record “pairs” on paper and tablet. 83 record pairs for 33 patients with 22 data items (temperature and symptoms) per pair were analysed. The overall Kappa coefficient for agreement between sources was 0.62, but Open Peer Review" 917 2486 W2473327186.pdf 0 15 separator 0.95722985 ¶ 2486 2488 W2473327186.pdf 0 16 title 0.93539995 Approval Status 2488 2504 W2473327186.pdf 0 17 separator 0.97750604 ¶ ¶ 2506 2512 W2473327186.pdf 0 18 table 0.59712076 1 2 2512 2516 W2473327186.pdf 0 19 separator 0.6538577 ¶ 2516 2518 W2473327186.pdf 0 20 table 0.9338166 "version 3 (revision) 23 Feb 2017 view version 2 (revision) 30 Sep 2016 view version 1 23 Jun 2016 view view" 2518 2650 W2473327186.pdf 0 21 separator 0.88761055 ¶ 2650 2652 W2473327186.pdf 0 22 contact 0.9888203 "James Whitworth , London School of Hygiene and Tropical Medicine, London, UK Hilary Bower , LSHTM, London, UK1. Benjamin O. Black , The Whittington Hospital, London, UK2." 2652 2839 W2473327186.pdf 0 23 separator 0.88434607 ¶ 2840 2842 W2473327186.pdf 0 24 contact 0.5200551 "Any reports and responses or comments on the article can be" 2842 2905 W2473327186.pdf 0 25 text 0.41612187 found at the end of the article 2905 2937 W2473327186.pdf 0 26 contact 0.46221197 . 2937 2938 W2473327186.pdf 0 27 separator 0.77245104 ¶ ¶ 2938 2944 W2473327186.pdf 0 28 paratext 0.97053325 Page 1 of 22F1000Research 2017, 5:1477 Last updated: 27 NOV 2023 2944 3009 W2473327186.pdf 0 0 paratext 0.9898389 Sensors 2023 ,23, 6538 6 of 13 0 30 W4384928866.pdf 5 1 separator 0.8663154 ¶ 30 32 W4384928866.pdf 5 2 paratext 0.9841033 Sensors 2023 , 23, x FOR PEER REVIEW 6 of 13 32 77 W4384928866.pdf 5 3 separator 0.8757004 "¶ ¶" 78 88 W4384928866.pdf 5 4 caption 0.9944329 Figure 3. Step length recovery trend (mean with 95% confidence intervals, n = 605). 88 173 W4384928866.pdf 5 5 separator 0.9951977 ¶ 175 177 W4384928866.pdf 5 6 title 0.9927838 3.3. Asymmetry Percentage 177 203 W4384928866.pdf 5 7 separator 0.99619216 ¶ 204 206 W4384928866.pdf 5 8 text 0.99927515 "Asymmetry percentage at pre-operative was 12.4 ± 12.4%, was greatest at week 2 (42.0 ± 32.6%, p < 0.001), recovered at week 7 (14.5 ± 19.4%, p = 0.046, and then was con- sistently less than pre-operative at week 10 (10.5 ± 14.7%, p < 0.001, Figure 4)." 206 463 W4384928866.pdf 5 9 separator 0.932804 ¶ ¶ 465 471 W4384928866.pdf 5 10 caption 0.9949338 Figure 4. Asymmetry percentage recovery trend (mean with 95% confidence intervals, n = 582). 471 565 W4384928866.pdf 5 11 separator 0.90737164 ¶ ¶ 567 574 W4384928866.pdf 5 12 caption 0.9949169 Figure 3. Step length recovery trend (mean with 95% confidence intervals, n = 605). 574 657 W4384928866.pdf 5 13 separator 0.9949295 ¶ 657 659 W4384928866.pdf 5 14 title 0.99235564 3.3. Asymmetry Percentage 659 685 W4384928866.pdf 5 15 separator 0.99584234 ¶ 685 687 W4384928866.pdf 5 16 text 0.99898136 "Asymmetry percentage at pre-operative was 12.4 12.4%, was greatest at week 2 (42.032.6%, p< 0.001), recovered at week 7 (14.5 19.4%, p= 0.046, and then was consistently less than pre-operative at week 10 (10.5 14.7%, p< 0.001, Figure 4)." 687 933 W4384928866.pdf 5 17 separator 0.99121475 ¶ 933 935 W4384928866.pdf 5 18 paratext 0.9845983 Sensors 2023 , 23, x FOR PEER REVIEW 6 of 13 935 980 W4384928866.pdf 5 19 separator 0.9554433 "¶ ¶" 981 991 W4384928866.pdf 5 20 caption 0.9948467 Figure 3. Step length recovery trend (mean with 95% confidence intervals, n = 605). 991 1076 W4384928866.pdf 5 21 separator 0.99475193 ¶ 1078 1080 W4384928866.pdf 5 22 title 0.99227804 3.3. Asymmetry Percentage 1080 1106 W4384928866.pdf 5 23 separator 0.99571955 ¶ 1107 1109 W4384928866.pdf 5 24 text 0.99939185 "Asymmetry percentage at pre-operative was 12.4 ± 12.4%, was greatest at week 2 (42.0 ± 32.6%, p < 0.001), recovered at week 7 (14.5 ± 19.4%, p = 0.046, and then was con- sistently less than pre-operative at week 10 (10.5 ± 14.7%, p < 0.001, Figure 4)." 1109 1366 W4384928866.pdf 5 25 separator 0.9293333 ¶ ¶ 1368 1374 W4384928866.pdf 5 26 caption 0.99459875 Figure 4. Asymmetry percentage recovery trend (mean with 95% confidence intervals, n = 582). 1374 1468 W4384928866.pdf 5 27 separator 0.8781562 ¶ ¶ 1470 1477 W4384928866.pdf 5 28 caption 0.99499565 Figure 4. Asymmetry percentage recovery trend (mean with 95% confidence intervals, n = 582). 1477 1569 W4384928866.pdf 5 0 paratext 0.9168806 "Pengaruh Customer Incivility terhadap Kelelahan Emosional 716 ¶ ¶ Buletin Riset Psikologi dan Kesehatan Mental (BRPKM) 2022 , Vol. 2(1), 711-719" 0 164 W4296921787.pdf 5 1 separator 0.7701964 "¶ ¶" 165 177 W4296921787.pdf 5 2 text 0.99918914 "linear sederhana untuk melihat pengaruh customer incivility terhadap kelelahan emosional , diperoleh hasil bahwa customer incivility memberikan pen garuh positif dan signifikan terhadap kelelahan emosional pada frontliner bank, artinya apabila customer incivility yang diterima oleh frontliner semakin tinggi , maka kelelahan emosional yang dirasakan juga akan semakin tinggi , dan begitu pula sebaliknya ." 177 594 W4296921787.pdf 5 3 separator 0.9801668 ¶ 596 598 W4296921787.pdf 5 4 text 0.9996079 "Hasil dalam penelitian ini sejalan dengan penelitian yang telah dilakukan sebelumnya oleh Cho dkk., (2016) , yaitu diperoleh hasil bahwa workplace incivility secara signifikan dapat meningkatkan kelelahan emosional yang dirasakan oleh karyawan. Workplace incivility ini di dalamnya termasuk perilaku incivility yang dilakukan oleh pelanggan ( customer incivility ), supervisor ( supervisor incivility ), dan rekan kerja ( co-worker incivility ). Namun, d alam penelitian tersebut tidak disebutkan besaran pengaruh dari workplace incivility terhadap kelelahan emosional . Dalam penelitian t ersebut hanya dijelaskan bahwa customer incivility memiliki nilai paling tinggi dalam meningkatkan kelelahan emosional yang dirasakan oleh karyawan. Sedangkan, dalam penelitian yang dilakukan peneliti, diperoleh hasil besaran pengaruh customer incivility terhadap kelelahan emosional sebesar 1 6,4%. Kekuatan pengaruh dalam penelitian ini dapat dikatakan cukup lemah, diduga karena customer incivility yang memiliki sifat ambigu dalam menyakiti targetnya (Pearson dkk., 2005) , sehingga terdapat perilaku yang sebenarnya termasuk dalam perilaku customer incivility , namun dianggap sebagai perilaku yang wajar oleh responden." 598 1855 W4296921787.pdf 5 5 separator 0.9832125 ¶ 1857 1859 W4296921787.pdf 5 6 text 0.9993341 "Berdasarkan hasil analisis regresi linear berganda dengan teknik Moderated Regression Analysis (MRA) untuk melihat peran regulasi emosi dalam memoderasi pengaruh customer incivility terhadap kelelahan emosional, diketahui bahwa terdapat kenaikan nilai koefisien determinasi sebelum dan sesudah ditambahkan variabel moderator berupa regulasi emosi cognitive reappraisal dan expressive suppression . Namun penin gkatan nilai koefisien determinasi yang tidak terlalu tinggi tersebut belum cukup kuat untuk membuktikan bahwa variabel moderator mampu memoderasi pengaruh customer incivility terhadap kelelahan emosional, sehingga diperlukan uji selanjutnya, yaitu dengan menggunakan uji F dan uji T. Selanjutnya, pada uji F diketahui bahwa customer incivility, regulasi emosi cognitive reappraisal, dan regulasi emosi expressive suppression memiliki pengaruh secara simultan atau serentak terhadap kelelahan emosional. Meskipun diketahui bahwa variabel customer incivility, regulasi emosi cognitive reappraisal, dan regulasi emosi expressive suppression berpengaruh secara simultan, namun hal tersebut belum bisa digunakan untuk menarik kesimpulan bahwa regulasi emosi cognit ive reappraisal dan regulasi emosi expressive suppression mampu memoderasi pengaruh customer incivility terhadap kelelahan emosional. Terakhir, dilakukan uji T dan diketahui interaksi antara customer incivility dan regulasi emosi cognitive reappraisal memi liki nilai koefisien parameter sebesar -0,028 dengan signifikansi sebesar 0, 480 (p>0,005), sedangkan interaksi antara customer incivility dan regulasi emosi expressive suppression memiliki nilai koefisien parameter sebesar -0,007 dengan signifikansi sebesa r 0,194 (p>0,005). Maka dapat disimpulkan bahwa variabel regulasi emosi cognitive reappraisal dan regulasi emosi expressive suppression tidak signifikan memoderasi pengaruh customer incivility terhadap kelelahan emosional." 1859 3837 W4296921787.pdf 5 7 separator 0.9863086 ¶ 3839 3841 W4296921787.pdf 5 8 text 0.9983736 "Hasil yang diperoleh pada penelitian ini tidak sejalan dengan hasil penelitian yang telah dilakukan sebelumnya oleh Donker dkk. (2020) . Perbedaan hasil tersebut diduga karena dipengaruhi oleh karakteristik responden yang digunakan dalam penelitian ini memiliki masa kerja yang cukup lama." 3841 4139 W4296921787.pdf 5 9 separator 0.98532724 ¶ 4140 4142 W4296921787.pdf 5 10 text 0.9364024 "Responden yang digunakan dalam p enelitian ini mayoritas memiliki masa kerja di atas 3 tahun (53,3%), dengan rincian sebagai berikut: responden dengan masa kerja selama 3 -5 tahun sebanyak 34 orang (32,4%), 6 -10 tahun sebanyak 15 orang (14,3%), dan di atas 10 tahun sebanyak 7 orang (6,7%)." 4142 4440 W4296921787.pdf 5 11 separator 0.9896067 ¶ 4442 4444 W4296921787.pdf 5 12 text 0.99953985 "Berdasarkan penelitian yang dilakukan oleh Park dkk . (2022) , diketahui bahwa semakin lama masa kerja seseorang, maka semakin seseorang tersebut beradaptasi dengan kebutuhan peran dalam pekerjaan mereka dan tela h memiliki pengendalian diri yang cukup kuat untuk memenuhi tuntutan" 4444 4732 W4296921787.pdf 5 0 paratext 0.9885889 Page 7 of 8 0 11 W4386251990.pdf 6 1 separator 0.55927384 11 12 W4386251990.pdf 6 2 paratext 0.94390154 ¶ Shafiee-Kandjani et al. BMC Psychiatry (2023) 23:631 12 76 W4386251990.pdf 6 3 separator 0.9748952 ¶ 77 79 W4386251990.pdf 6 4 title 0.9844449 Conclusions 79 91 W4386251990.pdf 6 5 separator 0.99135244 ¶ 91 93 W4386251990.pdf 6 6 text 0.99869376 "Recent studies showed schizophrenia associated with several abnormalities in the miRNAs and cytokines." 93 199 W4386251990.pdf 6 7 separator 0.6226785 ¶ 200 202 W4386251990.pdf 6 8 text 0.998963 "Alterations in cytokine levels and miRNAs expression may precede the first-episode of psychosis; thus, these serum markers might be useful for early illness detection strategies. The current study’s results showed that the miR-26a could be suggested as a potential biomarker for schizophrenia and related disorder diagnosis in the early stages. More analysis needs to be undertaken to clarify the miRNAs and the immune system’s involvement in this regard." 202 682 W4386251990.pdf 6 9 separator 0.9692267 ¶ 682 684 W4386251990.pdf 6 10 text 0.9980627 "It is recommended that miRNA levels assess by disease severity and clinical profiles to provide reliable evidence for the concoctions between higher levels of IL-6, IL-1β, TNF-α, and mi-RNAs in patients with schizophrenia in comparison with controls. This is a departure point for conducting future studies." 684 1007 W4386251990.pdf 6 11 separator 0.9963611 ¶ 1007 1009 W4386251990.pdf 6 12 title 0.9682026 Acknowledgements 1009 1026 W4386251990.pdf 6 13 separator 0.9884529 ¶ 1026 1028 W4386251990.pdf 6 14 text 0.9966842 "This work was elicited from the psychiatry residency dissertation of Dr. Negin Nejadettehad with the Reg. No. 59139 from the department of psychiatry, Tabriz University of Medical Sciences, Tabriz, Iran. We sincerely thank all the people and their family for their support and participation and all the medical staff involved in collecting blood samples." 1028 1395 W4386251990.pdf 6 15 separator 0.995905 ¶ 1395 1397 W4386251990.pdf 6 16 title 0.97066694 Authors’ contributions 1397 1420 W4386251990.pdf 6 17 separator 0.9854883 ¶ 1420 1422 W4386251990.pdf 6 18 text 0.98834735 "ARSh: Developed the original idea, protocol development and interpretation, and contributed in the manuscript development. Data collection, Data extraction, contributed to the development of the protocol: NN, SF, RB, DSh, and MH. Contributed to the manuscript development, review, revising, and analysis: HA. All the authors approved the final manuscript." 1422 1790 W4386251990.pdf 6 19 separator 0.99493647 ¶ 1790 1792 W4386251990.pdf 6 20 title 0.9595217 Funding 1792 1800 W4386251990.pdf 6 21 separator 0.9763156 ¶ 1800 1802 W4386251990.pdf 6 22 text 0.9859894 "The present study was financially supported, reviewed and supervised by Tabriz University of Medical Sciences to number 65618/D/5." 1802 1936 W4386251990.pdf 6 23 separator 0.9942689 ¶ 1936 1938 W4386251990.pdf 6 24 title 0.9698672 Data availability 1938 1956 W4386251990.pdf 6 25 separator 0.9756583 ¶ 1956 1958 W4386251990.pdf 6 26 text 0.984991 "The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request." 1958 2092 W4386251990.pdf 6 27 separator 0.99536216 ¶ 2092 2094 W4386251990.pdf 6 28 title 0.9692312 Declarations 2094 2107 W4386251990.pdf 6 29 separator 0.9867461 ¶ 2107 2109 W4386251990.pdf 6 30 title 0.92988694 Competing interests 2109 2129 W4386251990.pdf 6 31 separator 0.97494876 ¶ 2129 2131 W4386251990.pdf 6 32 text 0.98698634 The authors declare no competing interests. 2131 2175 W4386251990.pdf 6 33 separator 0.994039 ¶ 2175 2177 W4386251990.pdf 6 34 title 0.9799103 Ethics approval and consent to participate 2177 2220 W4386251990.pdf 6 35 separator 0.97998726 ¶ 2220 2222 W4386251990.pdf 6 36 text 0.996304 "This study was approved by ethics committee of Tabriz University of Medical Sciences to number: I.R.TBZMED.REC.1397.965. Written informed consent was obtained from all the subjects before the interview. For subjects who were under 18, written informed consent was obtained from the father or guardian of participants face to face after justifying the purpose of the study. Authors confirm that all methods were carried out in accordance with relevant guidelines and regulations." 2222 2719 W4386251990.pdf 6 37 separator 0.99347293 ¶ 2719 2721 W4386251990.pdf 6 38 paratext 0.5125202 Consent 2721 2729 W4386251990.pdf 6 39 title 0.5988327 for 2729 2733 W4386251990.pdf 6 40 paratext 0.58942467 publication 2733 2745 W4386251990.pdf 6 41 separator 0.7589457 ¶ 2745 2747 W4386251990.pdf 6 42 paratext 0.8987511 Not applicable. 2747 2763 W4386251990.pdf 6 43 separator 0.78059065 ¶ 2763 2765 W4386251990.pdf 6 44 paratext 0.98186463 Received: 21 April 2023 / Accepted: 24 August 2023 2765 2816 W4386251990.pdf 6 45 separator 0.98230827 ¶ 2816 2818 W4386251990.pdf 6 46 title 0.7810422 References 2818 2829 W4386251990.pdf 6 47 separator 0.9777912 ¶ 2829 2831 W4386251990.pdf 6 48 bibliography 0.9979923 "1. Miller BJ, Buckley P , Seabolt W, Mellor A, Kirkpatrick B. Meta-analysis of cyto - kine alterations in schizophrenia: clinical status and antipsychotic effects. 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In addition, monitoring TGFB1 could help manage CR to some extent, as TGFB1 triggers fibrogenesis linked to chronic rejection (CR). Further well-designed and unbiased studies with larger sample size, diverse ethnicities, donor-recipient pairing and various applications of CNIs should be conducted to verify our findings." 0 519 W1985304704.pdf 7 1 separator 0.83089405 ¶ 519 521 W1985304704.pdf 7 2 text 0.99584657 "Furthermore, functional studies of TGFB1 gene polymorphism are warranted to understand the underlying mechanisms." 521 637 W1985304704.pdf 7 3 separator 0.9957247 ¶ 637 639 W1985304704.pdf 7 4 title 0.9807338 Supporting Information 639 662 W1985304704.pdf 7 5 separator 0.9949695 ¶ 662 664 W1985304704.pdf 7 6 caption 0.98595595 "Figure S1 Begg’s funnel plot for publication bias test (LP vs. HP for TGFB1 haplotypes). (TIF)" 664 763 W1985304704.pdf 7 7 separator 0.96501756 ¶ 763 765 W1985304704.pdf 7 8 caption 0.99090105 "Figure S2 Begg’s funnel plot for publication bias test (IP vs. HP for TGFB1 haplotypes). (TIF)Figure S3 Begg’s funnel plot for publication bias test (LP/IP vs. HP for TGFB1 haplotypes). (TIF)" 765 965 W1985304704.pdf 7 9 separator 0.992625 ¶ 965 967 W1985304704.pdf 7 10 title 0.52257735 Checklist S1 PRISMA checklist. 967 998 W1985304704.pdf 7 11 separator 0.46113694 ¶ 998 1000 W1985304704.pdf 7 12 title 0.4890671 ( 1000 1002 W1985304704.pdf 7 13 caption 0.4654625 DOC 1002 1005 W1985304704.pdf 7 14 title 0.4914558 ) 1005 1006 W1985304704.pdf 7 15 separator 0.99410117 ¶ 1006 1008 W1985304704.pdf 7 16 title 0.7433251 "Table S1 Statistical analyses of publication bias for TGFB1 haplotypes at +869 T/C and +915 G/C polymor- phisms." 1008 1125 W1985304704.pdf 7 17 separator 0.4967706 ¶ 1125 1127 W1985304704.pdf 7 18 title 0.5743107 (DOC) 1127 1133 W1985304704.pdf 7 19 separator 0.9943073 ¶ 1133 1135 W1985304704.pdf 7 20 title 0.95247453 Author Contributions 1135 1156 W1985304704.pdf 7 21 separator 0.99196273 ¶ 1156 1158 W1985304704.pdf 7 22 text 0.97798896 "Conceived and designed the experiments: YZG RPJ. Performed the experiments: YZG RW TZL MHL XFG XMJ XBZ LPL SJT QS WCLJGZ. Analyzed the data: YZG RW TZL WCL JGZ. Contributedreagents/materials/analysis tools: YZG MHL XFG XBZ LPL. Wrotethe paper: YZG RW LPL. Proofread and revised the paper: RPJ." 1158 1454 W1985304704.pdf 7 23 separator 0.99459124 ¶ 1454 1456 W1985304704.pdf 7 24 title 0.54936147 References 1456 1467 W1985304704.pdf 7 25 separator 0.9854747 ¶ 1467 1469 W1985304704.pdf 7 26 bibliography 0.9978468 "1. Li MO, Flavell RA (2008) TGF-beta: a master of all T cell trades. Cell 134: 392– 404." 1469 1560 W1985304704.pdf 7 27 separator 0.82815826 ¶ 1560 1562 W1985304704.pdf 7 28 bibliography 0.99814254 "2. Blobe GC, Schiemann WP, Lodish HF (2000) Role of transforming growth factor beta in human disease. N Engl J Med 342: 1350–1358." 1562 1695 W1985304704.pdf 7 29 separator 0.8376572 ¶ 1695 1697 W1985304704.pdf 7 30 bibliography 0.99807024 "3. 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J Heart Lung Transplant 31: 1052–1064.TGFB1 Haplotypes and Acute Rejection" 8521 8811 W1985304704.pdf 7 101 separator 0.94158554 ¶ 8811 8813 W1985304704.pdf 7 102 paratext 0.98053384 PLOS ONE | www.plosone.org 8 April 2014 | Volume 9 | Issue 4 | e93938 8813 8883 W1985304704.pdf 7 0 text 0.99184173 "stated in the Background sect ion, mixing assembly tools mostly provided inferior results, however for some cases GAA managed to improve the N50 size with an increaseof>80%." 0 177 W2057420059.pdf 5 1 separator 0.9617485 ¶ 177 179 W2057420059.pdf 5 2 text 0.9996485 "We applied GAA and GAM-NGS for all pairwise combinations of 8 assemblers twice (accounting for the asymmetry). We evaluated Mix results against those for the 8 assemblers, as well as merged assemblies produced by GAA and GAM-NGS. All e valuations were per- formed using QUAST [19] under the same parametersas GAGE-B. Three different types of metrics are used byQUAST. First, classical asse mbly statistics based on the distribution of the length of each contig of an assembly.These statistics do not require any reference genome and are used to measure the fragmentation of an assem- bly. A second set of statistics is derived from an align-ment of the assembly against a reference genome.Contigs that are aligned over distant locations in thereference genome or that c ontain misassemblies are split, and fragmentation is measured over the split con-tigs. Using these alignments, additional measures reportthe ratio of duplication as well as the fraction of the reference genome that is covered by an assembly. A third, more robust, statistics is derived from the conser-vation of gene products. These last two statistics can bemeasured only if a fully assembled and annotated refer-ence genomes is provided." 179 1411 W2057420059.pdf 5 3 separator 0.98500764 ¶ 1411 1413 W2057420059.pdf 5 4 text 0.9994961 "In total 1171 different assemblies were produced by crossing each species, master and slave assembler data-sets (for GAM and GAA) and all possible pairs of assem- blers for Mix . All original assemblies were downloaded from the GAGE-B website, they consist of contigs assem- blies and correspond to HiSeq libraries, with the excep-tion of B. cereus for which we used assemblies based on MiSeq libraries in order to match the GAGE-B setup.Only 13 species/merger/assemblers combination aremissing from the full factorial setup. Figure 3 reports theNA50 distributions per species and assembly merger con- trasted with single (unmerged) assemblies. Two species are missing from this figure, X. axonopodis andA. hydro- phila , since the strain sequenced during the GAGE-B pro- ject is too distant from the reference genome to computea NA50 value (this holds for all assemblies for these twospecies). In setups where a close-enough reference genomeis not available, the sole statistics available to “score ” assemblies are based on fragmentation measures, notably the N50. To simulate such reference-less setup, we selected for each species and each assembly merger thetop 5 assemblies when ranked by N50. By analyzing howthese “blindly ”selected top N50 assemblies are scored with regards to statistics based on a reference genome, wecan analyze the soundness of this selection heuristic." 1413 2823 W2057420059.pdf 5 5 separator 0.9903548 ¶ 2823 2825 W2057420059.pdf 5 6 text 0.9996017 "In Figure 3, we observe that for all but S. aureus either GAM-NGS or Mix improve the single assemblysubstantially. Notably for B. cereus , for which the authors of GAGE-B already reported some improvement over sin-gle assemblies when using GAA, we manage with GAM orMix to improve even more. The best Mix assembly for B. cereus stitches 90 contigs from MaSuRCA and 105 from SOAP into 47 contigs (including 4 extension paths), improving the NA50 score by 97%(NA50 of 487kb). For five out of six species, one of the top 5 assemblies gener-ated by Mix is better than the best GAA, GAM and single assemblies. In particular, Mix significantly improves statis- tics measuring fragmentation of assemblies (for completeresults, see results and figures available at https://github.com/cbib/MIX), as well as alignments of contigs. Similarplots and tabular data for other QUAST statistics are available on the accompanying MIX website. These also show the asymmetry in the results when one or another ofassemblies is treated as target (resp., master) by GAA(resp., GAM-NGS)." 2825 3909 W2057420059.pdf 5 7 separator 0.9904219 ¶ 3909 3911 W2057420059.pdf 5 8 text 0.99950606 "Of particular concern when merging multiple assemblies is the potential increase in duplication. Indeed, the bottompanel of Figure 3 shows that overall, the mean duplicationratio for Mix is higher than for other assemblers, the worst case happening for V. cholera where one of Mix top 5 assemblies has a duplication that is out of range of theothers. It is worth noting however that generally the dupli-cation ratio of Mix assemblies stays within the same range as that produced by other assemblers (on the order of1-2%). Finally and most importantly, we also observe thatselecting assemblies solely based on the N50 value oftenselects the best assemblies, as validated by additional refer- ence-genome based statistics." 3911 4642 W2057420059.pdf 5 9 separator 0.9968401 ¶ 4642 4644 W2057420059.pdf 5 10 title 0.99145544 Application to Mycoplasma genomes 4644 4678 W2057420059.pdf 5 11 separator 0.9948041 ¶ 4678 4680 W2057420059.pdf 5 12 text 0.9996524 "We have assembled the 10 newly sequenced genomes of bacteria belonging to the genus Mycoplasma. Mycoplas- mas are small bacteria often portrayed as the best repre- sentative of the minimal cell. Indeed, their genomes areextremely reduced ( i.e., 0.58 to 1.4 Mbp) with a low GC- content, most of them ranging from 24 to 30%. For theMycoplasma genomes the available NGS data consisted in 454 and Illumina (mate pair ed) reads, produced in the frame of the ANR EVOLMYCO project (see Table 1)." 4680 5182 W2057420059.pdf 5 13 separator 0.97031856 ¶ 5182 5184 W2057420059.pdf 5 14 text 0.99922097 "To build input assemblies we have chosen three assemblers: ABySS, MIRA and CLC. Two of them werechosen based on the GAGE-B study by considering thefollowing points." 5184 5351 W2057420059.pdf 5 15 separator 0.93871176 ¶ 5351 5353 W2057420059.pdf 5 16 text 0.94202024 "1. SPAdes [20] was the winner in terms of N50. How-ever it produced a large nu mber of small, unaligned contigs and was consequently excluded from our study.2. ABySS consistently produced assemblies with thefewest errors and had the second best N50.3. MIRA produced a large corrected N50 with errorsoccurring mostly in smaller contigs." 5353 5691 W2057420059.pdf 5 17 bibliography 0.7034424 Soueidan et al .BMC Bioinformatics 2013, 14(Suppl 15 5691 5743 W2057420059.pdf 5 18 paratext 0.5557837 ):S16 5743 5748 W2057420059.pdf 5 19 separator 0.9288396 ¶ 5748 5750 W2057420059.pdf 5 20 paratext 0.9825344 http://www.biomedcentral.com/1471-2105/14/S15/S16Page 6 of 11 5750 5812 W2057420059.pdf 5 0 paratext 0.98433495 "Page 2 of 15 Original Research http://www.sajhrm.co.za Open Access" 0 68 W4389579505.pdf 1 1 separator 0.9933319 ¶ 68 70 W4389579505.pdf 1 2 text 0.99894065 "Van Stormbroek & Blomme, 2017), less attention has been given to the influence of socio-demographical differences on the relationship between these two concepts (Deas, 2017; Rafiee et al., 2015). Furthermore, there is a shortage of research on socio-demographic differences among employees in HEIs – especially in open-distance learning (ODL) institutions – in terms of how employees’ psychological contracts impact staff retention (Deas, 2018; Peltokorpi et al., 2015; Rafiee et al., 2015)." 70 583 W4389579505.pdf 1 3 separator 0.9637549 ¶ 584 586 W4389579505.pdf 1 4 text 0.9996201 "Based on the high staff turnover rates at HEIs in SA (Barkhuizen et al., 2020), as well as the diversity of the workforce at these institutions (Setati et al., 2019), it is imperative that these institutions develop and implement retention strategies aimed at strengthening the retention of their valuable and diverse employees. Therefore, the present study aims to address this gap by specifically exploring the socio-demographical differences among employees in HEIs, and the role these differences play in the relationship between their psychological contract-related perceptions and the retention of staff. The findings of the study can therefore potentially add valuable new insights that could inform retention practices for diverse employees employed in the HE environment." 586 1403 W4389579505.pdf 1 5 separator 0.9943531 ¶ 1404 1406 W4389579505.pdf 1 6 title 0.99011517 Staff retention in the higher education context 1406 1454 W4389579505.pdf 1 7 separator 0.99352646 ¶ 1454 1456 W4389579505.pdf 1 8 text 0.9990053 "Higher education institutions in SA face immense difficulties in terms of skilled human resources and retention of their valuable and skilled employees, which has a devastating effect on the successful functioning of these institutions (Abugre, 2018; Barkhuizen et al., 2020; Deas, 2018; Erasmus et al., 2015; Gerstein & Friedman, 2016; Mukwawaya, 2022; Musakuro, 2022; Robyn, 2012; Tettey, 2006). Previous research suggests that there may be as much as a 13 % shortage of academic and support staff at HEIs (Abugre, 2018; Deas & Coetzee, 2020; Dewhurst et al., 2013). Research by Theron et al. (2014) determined that 33.8 % of employees in South African HEIs showed a strong intention to leave their institutions. Higher Education of South Africa (HESA, 2011), Lindathaba-Nkadimene (2020), as well as Omodan (2022) likewise, concluded that HEIs are battling with poor levels of staff retention and high labour turnover." 1456 2422 W4389579505.pdf 1 9 separator 0.9424311 ¶ 2422 2424 W4389579505.pdf 1 10 text 0.9993919 "If HEIs are not able to retain their key employees, they will not be able to remain competitive and offer quality services (Hailu et al., 2013). The high staff turnover in HEIs may be resulting from several challenges experienced in the HE sector, such as financial constraints, uncompetitive remuneration packages, mergers, acquisitions, job insecurity, lack of resources, and an overload of demands placed on employees (Balakrishnan & Vijayalakshmi, 2014; Ngobeni & Bezuidenhout, 2011; Robyn & Du Preez, 2013). Furthermore, South African HEIs operate in a multifaceted milieu with a socio-demographically diverse labour force." 2424 3083 W4389579505.pdf 1 11 separator 0.975103 ¶ 3083 3085 W4389579505.pdf 1 12 text 0.9994292 "In a South African study, Döckel (2003) identified six crucial retention factors (also referred to as retention practices) that organisations should consider when developing and implementing retention strategies (Döckel et al., 2006; Van Dyk & Coetzee, 2012). These factors comprise: compensation, job characteristics, opportunities for training and development, supervisor support, career opportunities, and work-life balance policies." 3085 3540 W4389579505.pdf 1 13 separator 0.8957342 ¶ 3540 3542 W4389579505.pdf 1 14 text 0.99924874 "Thus, effective capacity building, and staff retention along with the type of relationship which progresses between diverse groups of employees and their employers, will ultimately determine the success of HEIs (Armstrong & Taylor, 2014; Festing & Schäfer, 2014; Guo, 2017; Mukwawaya, 2022; Snyman, 2022). Employees are one of the most important assets of any organisation, and in order to ensure the success and efficient functioning of these institutions, it is imperative for HEIs to develop and implement retention practices which take the needs of various socio-demographic groups into account." 3542 4169 W4389579505.pdf 1 15 separator 0.944185 ¶ 4170 4172 W4389579505.pdf 1 16 text 0.9981474 "Higher education institutions can only diagnose and prevent turnover of their employees when there is a fruitful employment relationship and the diverse needs of their employees are appreciated and incorporated into retention practices (Grobler & Jansen van Rensburg, 2019; Ng’ethe et al., 2012)." 4172 4482 W4389579505.pdf 1 17 separator 0.99606717 ¶ 4482 4484 W4389579505.pdf 1 18 title 0.9913386 "The relationship between the psychological contract and staff retention" 4484 4559 W4389579505.pdf 1 19 separator 0.99422514 ¶ 4559 4561 W4389579505.pdf 1 20 text 0.999552 "For HEIs to develop and implement retention strategies and practices aimed at addressing the high turnover levels, it is important to determine the factors that may have an impact on employees’ decision to stay with or leave their organisation." 4561 4815 W4389579505.pdf 1 21 separator 0.9347329 ¶ 4816 4818 W4389579505.pdf 1 22 text 0.9994248 "Empirical evidence shows that the type of relationship that exists between employees and their employer, and the extent to which employees perceive their employer to adhere to commitments made within the relationship, strongly impact retention (Guest, 2004; Le Roux & Rothman, 2013; Van Stormbroek & Blomme, 2017). This may be referred to as the psychological contract between employees and employers (Bal & Kooij, 2011; Rousseau, 1989). The psychological contract is a subjective, unwritten, open-ended contract based on the reciprocal expectations of both parties to the employment relationship (Eds. Guest et al., 2010; Kraak et al., 2017; Rousseau, 1989; 1990; 1995)." 4818 5523 W4389579505.pdf 1 23 separator 0.9669065 ¶ 5523 5525 W4389579505.pdf 1 24 text 0.9995261 "The state of employees’ psychological contracts is largely determined by the extent to which perceived promises made to them have been kept and obligations adhered to (Van der Vaart et al., 2013; Van Stormbroek & Blomme, 2017). The psychological contract is the basis of the employment relationship and has an enormous impact on employee retention (Guest, 1998; Kraak et al., 2017; Van der Vaart et al., 2015). When employees have a strong psychological contract with their employer, they are less likely to leave their organisation and more likely to be committed to their employer (Chin & Hung, 2013; Deas, 2017; Ngakantsi, 2022)." 5525 6188 W4389579505.pdf 1 25 separator 0.9838257 ¶ 6189 6191 W4389579505.pdf 1 26 text 0.99858767 "Previous studies concur that perceived psychological contract breach negatively affects commitment and retention, and increases both planned and actual turnover (Deas, 2017; Peirce et al., 2012; Snyman, 2021; Van Dijk & Ramatswi, 2016)." 6191 6437 W4389579505.pdf 1 27 separator 0.96576226 ¶ 6437 6439 W4389579505.pdf 1 28 text 0.99866074 "A study by Deas (2017) showed that positive psychological contract-related perceptions are associated with higher satisfaction with the human resource factors that influence retention, namely, compensation, job characteristics, training and development opportunities, supervisor support, career" 6439 6746 W4389579505.pdf 1 0 paratext 0.7539234 "T[a_XW[i[`SUSS_S^[ǜeYfc`S^[ ¬Yfc`S^T[a_XW[i[`n[bcS]e[][ ¬ ɮɸ ɖɹ ɮ ɖɮɹɹ No2 | 2022 3 ¶ ¶" 0 189 W4281767651.pdf 2 1 table 0.35564244 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 191 281 W4281767651.pdf 2 2 paratext 0.24745524 283 284 W4281767651.pdf 2 3 table 0.2848308 ¶ 284 285 W4281767651.pdf 2 4 paratext 0.30216265 ¶ ¶ 287 293 W4281767651.pdf 2 5 separator 0.67880696 ¶ ¶ 295 301 W4281767651.pdf 2 6 contact 0.7103866 Верстка: Хуршид Мирзахмедов 302 330 W4281767651.pdf 2 7 separator 0.854689 ¶ 332 334 W4281767651.pdf 2 8 contact 0.9723805 "Контакт редакций журналов. www.tadqiqot.uz ООО Tadqiqot город Ташкент, улица Амира Темура пр.1, дом -2. Web: http://www.tadqiqot.uz/; E -mail: info@tadqiqot.uz Тел: (+998 -94) 404-0000 Editorial staff of the journals of www.tadqiqot.uz" 334 586 W4281767651.pdf 2 9 separator 0.6638175 ¶ 588 590 W4281767651.pdf 2 10 contact 0.9624037 "Tadqiqot LLC The city of Tashkent, Amir Temur Street pr.1, House 2. Web: http://www.tadqiqot.uz/; E -mail: info@tadqiqot.uz Phone: (+998 -94) 404 -0000 Y" 590 757 W4281767651.pdf 2 11 paratext 0.8953536 fc`S^T[a_XW[i[`n[bcS]e[][ 757 785 W4281767651.pdf 2 12 separator 0.6213542 ¶ 787 789 W4281767651.pdf 2 13 paratext 0.973396 No2 (2022) DOI http://dx.doi.org/10.26739/2181 -9300 -2022-2 789 849 W4281767651.pdf 2 14 separator 0.99484193 ¶ 850 852 W4281767651.pdf 2 15 contact 0.9395938 "Главный редактор: ¶ Ризаев Жасур Алимджанович доктор медицинских наук, профессор, Ректор Самаркандского государственного медицинского института , ORCID ID: 0000 -0001 -5468 -9403 Заместитель главного редактора: ¶ Зиядуллаев Шухрат Худайбердиевич доктор медицинских наук, проректор по научной работе и инновациям Самаркандского государственного медицинского института , ORCID ID: 0000 -0002 -9309 -3933" 852 1290 W4281767651.pdf 2 16 separator 0.9730984 ¶ 1292 1294 W4281767651.pdf 2 17 contact 0.9544426 "Ответственный секретарь: Самиева Гульноза Уткуровна доктор медицинских наук, доцент Самаркандского государственного медицинского института ." 1294 1446 W4281767651.pdf 2 18 separator 0.49390057 1448 1449 W4281767651.pdf 2 19 contact 0.5600037 ¶ ORCID 1449 1456 W4281767651.pdf 2 20 table 0.50145644 ID 1456 1459 W4281767651.pdf 2 21 contact 0.49587715 : 1459 1460 W4281767651.pdf 2 22 table 0.51560026 0000 - 1461 1468 W4281767651.pdf 2 23 contact 0.49928886 0002 1468 1472 W4281767651.pdf 2 24 table 0.5241345 1472 1473 W4281767651.pdf 2 25 contact 0.5331199 -6142 1473 1478 W4281767651.pdf 2 26 table 0.47551 1478 1479 W4281767651.pdf 2 27 contact 0.5767603 -7054 1479 1484 W4281767651.pdf 2 28 separator 0.90479004 ¶ 1486 1488 W4281767651.pdf 2 29 math 0.6880341 cXWS]i[a``n\]a^^XV[r ” 1488 1512 W4281767651.pdf 2 30 separator 0.879156 ¶ 1513 1515 W4281767651.pdf 2 31 contact 0.8245534 "Хаитов Рахим Мусаевич академик РАН, доктор медицинских наук, профессор, заслуженный деятель науки Российской Федерации, научный руководитель ФГБУ ""ГНЦ Институт иммунологии"" ФМБА России." 1515 1717 W4281767651.pdf 2 32 separator 0.8912591 ¶ ¶ 1719 1725 W4281767651.pdf 2 33 contact 0.811601 "Jin Young Choi профессор департамента оральной и челюстно -лицевой хирургии школы стоматологии Стоматологического госпиталя Сеульского национального университета, Президент Корейского общества челюстно -лицевой и эстетической хирургии" 1725 1981 W4281767651.pdf 2 34 separator 0.8710391 ¶ ¶ 1983 1989 W4281767651.pdf 2 35 contact 0.6254897 "Гулямов Сур ъат Саидвалиевич доктор медицинских наук., профессор Проректор по научной работе и инновациям в Ташкентском педиатрическом медицинском институте." 1989 2157 W4281767651.pdf 2 36 bibliography 0.54183674 ORCID ID : 0000 -0002 -9444 2158 2187 W4281767651.pdf 2 37 contact 0.5229668 -4555 2187 2192 W4281767651.pdf 2 38 separator 0.7820688 ¶ 2194 2196 W4281767651.pdf 2 39 contact 0.40107572 2198 2199 W4281767651.pdf 2 40 separator 0.43863043 ¶ 2199 2200 W4281767651.pdf 2 41 contact 0.73274285 "Абдуллаева Наргиза Нурмаматовна доктор медицинских наук, профессор , проректор Самаркандского государственного медицинского института , Главный врач 1 -клиники . OR" 2200 2378 W4281767651.pdf 2 42 bibliography 0.41878217 CID ID: 0000 2378 2391 W4281767651.pdf 2 43 contact 0.48962596 2391 2392 W4281767651.pdf 2 44 bibliography 0.41767514 -0002 2392 2398 W4281767651.pdf 2 45 contact 0.46501732 -7529 -4248 2398 2409 W4281767651.pdf 2 46 separator 0.59074306 ¶ 2411 2413 W4281767651.pdf 2 47 contact 0.6303941 "¶ Худоярова Дилдора Рахимовна доктор медицин" 2415 2464 W4281767651.pdf 2 48 bibliography 0.3946236 ских 2464 2468 W4281767651.pdf 2 49 contact 0.39448887 наук 2468 2473 W4281767651.pdf 2 50 bibliography 0.42896777 , 2473 2474 W4281767651.pdf 2 51 contact 0.40432987 до 2474 2477 W4281767651.pdf 2 52 bibliography 0.4267524 цент, 2477 2482 W4281767651.pdf 2 53 contact 0.50518435 заведующая 2482 2493 W4281767651.pdf 2 54 bibliography 0.44698662 кафедрой ¶ 2493 2505 W4281767651.pdf 2 55 contact 0.4937415 Акушерства и гинекологии No1 Самарканд 2505 2543 W4281767651.pdf 2 56 bibliography 0.4820024 ского ¶ 2543 2551 W4281767651.pdf 2 57 contact 0.4684263 государственного медицинского института ¶ 2551 2595 W4281767651.pdf 2 58 bibliography 0.46350268 ORCID ID: 0000 -0001 2595 2618 W4281767651.pdf 2 59 table 0.37895536 - 2618 2619 W4281767651.pdf 2 60 bibliography 0.39871982 5770 - 2619 2625 W4281767651.pdf 2 61 contact 0.42699635 2255 2625 2629 W4281767651.pdf 2 62 separator 0.47169036 ¶ 2631 2633 W4281767651.pdf 2 63 contact 0.595745 ¶ Раббимова Дилфуза Таштемировна 2635 2668 W4281767651.pdf 2 64 bibliography 0.44186246 ¶ кандидат медицинских наук, доцент, завед 2670 2713 W4281767651.pdf 2 65 contact 0.40231076 ующая ¶ 2713 2721 W4281767651.pdf 2 66 bibliography 0.5044403 "кафедрой Пропедевтики детских болезней Самаркандского государственного медицинского института ORCID ID : 0000 -0003 -4229 -6017" 2721 2856 W4281767651.pdf 2 67 separator 0.46285442 ¶ 2858 2860 W4281767651.pdf 2 68 contact 0.314358 2862 2863 W4281767651.pdf 2 69 table 0.28987134 ¶ 2863 2864 W4281767651.pdf 2 70 contact 0.5466086 Орипов Фирдавс Суръат 2864 2886 W4281767651.pdf 2 71 bibliography 0.5387097 "ович доктор медицинских наук, доцент, заведующий кафедрой Гистологии, цитологии и эмбриологии Самаркандского государственного медицинского института ORCID ID : 0000 -0002 -0615 -0144" 2886 3082 W4281767651.pdf 2 72 separator 0.49333453 ¶ 3084 3086 W4281767651.pdf 2 73 contact 0.5339932 ¶ Ярмухамедова Саодат Хабибовна 3088 3120 W4281767651.pdf 2 74 bibliography 0.531289 "¶ кандидат медицинских наук, доцент, заведующая кафедрой Пропедевтики внутренных болезней Самаркандского государственного медицинского института ORCID ID : 0000-0001 -5975 -1261" 3122 3310 W4281767651.pdf 2 75 separator 0.48113006 ¶ 3312 3314 W4281767651.pdf 2 76 contact 0.334417 3316 3317 W4281767651.pdf 2 77 separator 0.29267886 ¶ 3317 3318 W4281767651.pdf 2 78 contact 0.5923479 "Мавлянов Фарход Шавкатович доктор" 3318 3356 W4281767651.pdf 2 79 bibliography 0.4334031 медицинских наук, доцент кафедры 3356 3389 W4281767651.pdf 2 80 contact 0.42116654 Дет 3389 3393 W4281767651.pdf 2 81 bibliography 0.4643337 "ской хирургии Самаркандского государственного медицинского института ORCID ID: 0000" 3393 3484 W4281767651.pdf 2 82 table 0.3837006 3484 3485 W4281767651.pdf 2 83 bibliography 0.45767918 -0003 -2650 -4445 3485 3502 W4281767651.pdf 2 84 contact 0.5450067 Акбаров Миршавкат Миролим 3503 3529 W4281767651.pdf 2 85 bibliography 0.5772804 "ович доктор медицинских наук, Республиканский специализированный центр хирургии имени академика В.Вахидова" 3529 3649 W4281767651.pdf 2 86 separator 0.37562913 ¶ 3651 3653 W4281767651.pdf 2 87 contact 0.34754914 3655 3656 W4281767651.pdf 2 88 separator 0.41945434 ¶ 3656 3657 W4281767651.pdf 2 89 contact 0.5041882 Саидов Саидамир Аброрович 3658 3684 W4281767651.pdf 2 90 bibliography 0.5156669 "¶ доктор медицинских наук, Ташкентский фармацевтический институт ORCID ID: 0000 -0002 -6616 -5428" 3687 3796 W4281767651.pdf 2 91 separator 0.48119482 ¶ ¶ 3798 3804 W4281767651.pdf 2 92 contact 0.5071869 Тураев Феруз Фатхулла 3805 3827 W4281767651.pdf 2 93 bibliography 0.5439444 "евич доктор медицинских наук, главный научный с отрудник отделения приобретенных пороков сердца Республиканского специализированного центра хирургии имени академика В.Вахидова ." 3827 4024 W4281767651.pdf 2 94 separator 0.48134312 ¶ 4026 4028 W4281767651.pdf 2 95 bibliography 0.4897282 ORCID ID: 0000 4028 4043 W4281767651.pdf 2 96 table 0.45855895 4043 4044 W4281767651.pdf 2 97 bibliography 0.4485343 -0002 4044 4049 W4281767651.pdf 2 98 table 0.47804505 - 4049 4051 W4281767651.pdf 2 99 bibliography 0.4349778 6778 4051 4055 W4281767651.pdf 2 100 table 0.3997634 4055 4056 W4281767651.pdf 2 101 bibliography 0.37826568 -69 4056 4059 W4281767651.pdf 2 102 contact 0.35329896 20 4059 4061 W4281767651.pdf 2 103 separator 0.6280135 ¶ ¶ 4063 4069 W4281767651.pdf 2 104 contact 0.59834397 Худанов Бахтинур Ойб утаевич 4070 4099 W4281767651.pdf 2 105 bibliography 0.49261457 ¶ доктор медицинских наук, Минист 4101 4135 W4281767651.pdf 2 106 contact 0.467069 ерство 4135 4141 W4281767651.pdf 2 107 bibliography 0.5507201 ¶ Инновационного развития 4143 4169 W4281767651.pdf 2 108 contact 0.45658907 Республик 4169 4179 W4281767651.pdf 2 109 bibliography 0.46052438 и 4179 4180 W4281767651.pdf 2 110 contact 0.5410008 Узбекистан 4181 4192 W4281767651.pdf 2 111 separator 0.41294122 ¶ ¶ 4194 4200 W4281767651.pdf 2 112 contact 0.49815 Бабаджан 4200 4209 W4281767651.pdf 2 113 bibliography 0.7000437 "ов Ойбек Абдужаббарович доктор медицинских наук, Ташкентский педиатрический медицинский институт, кафедра Дерматовенерология, детская дерматовенерология и СПИД , ORCID ID: 0000 -0002 -3022 -916X" 4209 4415 W4281767651.pdf 2 114 separator 0.49402422 ¶ ¶ 4417 4423 W4281767651.pdf 2 115 bibliography 0.47748056 Теребаев Билим Ал 4423 4441 W4281767651.pdf 2 116 contact 0.4965412 даму 4441 4445 W4281767651.pdf 2 117 bibliography 0.5807747 "ратович кандидат медицинских наук, доцент кафедры Факультетской детской хирургии Ташкентского педиатрического медицинского института ." 4445 4589 W4281767651.pdf 2 118 separator 0.33855468 4591 4592 W4281767651.pdf 2 119 bibliography 0.46531844 ¶ ORCID ID: 0000 4592 4609 W4281767651.pdf 2 120 table 0.44359803 - 4609 4611 W4281767651.pdf 2 121 bibliography 0.44170004 0002 4611 4615 W4281767651.pdf 2 122 table 0.45184377 -5409 -4327 4615 4627 W4281767651.pdf 2 123 separator 0.5284547 ¶ 4629 4631 W4281767651.pdf 2 124 contact 0.31219026 4633 4634 W4281767651.pdf 2 125 separator 0.27297255 ¶ 4634 4635 W4281767651.pdf 2 126 contact 0.53039485 Юлдашев Ботир Ахмат 4635 4655 W4281767651.pdf 2 127 bibliography 0.5655398 "ович кандидат медицинских наук, доцент кафедры Педиатрии, неонаталогии и пропедевтики детских болезней No2 Самаркандского государственного медицинского института ORCID ID: 0000 -0003 " 4655 4853 W4281767651.pdf 2 128 table 0.441335 - 4853 4854 W4281767651.pdf 2 129 bibliography 0.4851653 2442 -1523 4854 4864 W4281767651.pdf 2 130 separator 0.42023173 ¶ ¶ 4866 4872 W4281767651.pdf 2 131 contact 0.51137996 Эшкобило 4872 4881 W4281767651.pdf 2 132 bibliography 0.6250578 "в Тура Жураевич кандидат медицинских наук, доцент кафедры Судебной медицины и патологической анатомии Самаркандского государственного медицинского института ORCID ID: 0000 -0003 " 4881 5075 W4281767651.pdf 2 133 table 0.43402815 -39 5075 5078 W4281767651.pdf 2 134 bibliography 0.42009562 14 -7221 5078 5086 W4281767651.pdf 2 135 separator 0.43593377 ¶ 5088 5090 W4281767651.pdf 2 136 table 0.3339072 ¶ 5092 5094 W4281767651.pdf 2 137 bibliography 0.46039757 Рахимов 5094 5102 W4281767651.pdf 2 138 contact 0.4669911 Нодир Махамматкул 5102 5120 W4281767651.pdf 2 139 bibliography 0.4973617 "ович доктор медицинских наук, доцент кафедры онкологии Самарнкандского медицинского института ORCID ID: 0000 -0001 " 5120 5249 W4281767651.pdf 2 140 table 0.48669016 - 5249 5250 W4281767651.pdf 2 141 bibliography 0.41984978 5272 5250 5255 W4281767651.pdf 2 142 table 0.4064948 -55 5255 5258 W4281767651.pdf 2 143 bibliography 0.41386744 03 5258 5260 W4281767651.pdf 2 144 contact 0.8835584 "Ответственный за публикацию : Абзалова Шахноза Рустамовна кандидат медицинских наук, доцент, Ташкентский педиатрический медицинский институт." 5261 5414 W4281767651.pdf 2 145 separator 0.42214262 5416 5417 W4281767651.pdf 2 146 contact 0.35150316 ¶ 5417 5418 W4281767651.pdf 2 147 table 0.46642828 ORCID ID: 0000 -0002 -0066 -35 5418 5450 W4281767651.pdf 2 148 contact 0.40111488 47 5450 5452 W4281767651.pdf 2 149 separator 0.9953203 ¶ 5454 5456 W4281767651.pdf 2 0 separator 0.9905313 ¶ 1 2 W4281761797.pdf 3 1 title 0.98743105 XUL Q 2 8 W4281761797.pdf 3 2 separator 0.9963137 ¶ 9 11 W4281761797.pdf 3 3 text 0.9994992 "Inson ikki narsadan murakkabdur. Biri jasad, ikkinchisi nafsdur. Jasad ko’z ila bor narsalarni ko’rur. Ammo nafs idrok ila yaxshini yomondan, oqni qoradan ayirur. Jasadning ham, nafsning ham biror surati bordurki, yo yaxshi va yo yomon bo’ladur." 11 266 W4281761797.pdf 3 4 separator 0.99677306 ¶ 268 270 W4281761797.pdf 3 5 title 0.98757046 YAXSHI X ULQ, YOMON XULQ 270 295 W4281761797.pdf 3 6 separator 0.99403495 ¶ 297 299 W4281761797.pdf 3 7 text 0.9993369 "Axloq ulamosi insonlarning xulqlarini ikkiga bo’lmishlar Agar nafs tarbiyat topib, yaxshi ishlarni qilurga odat qilsa, yaxshilikg’a tavsif bo’lub, «yaxshi xulq» agar tarbiyatsiz o’sub, yomon ishlaydurgan bo’lub ketsa, yomonliqg’a tavsif bo’lub «yomon xulq» deb atalur." 299 577 W4281761797.pdf 3 8 separator 0.88624966 ¶ 579 581 W4281761797.pdf 3 9 text 0.99936485 "«Qush uyasinda ko’rganin qiladur». Inson javhari qobildur. Agar yaxshi tarbiya topib, buzuq xulqlardan saqlanub, go’zal xulqlarga odatlanub katta bo’lsa, har kim qoshida maqbul, baxtiyor bir inson bo’lub chiqar. Agar tarbiyatsiz, axloqi buzulub o’ssa, Allohdan qo’rqmaydurgan, shariatga amal qilmaydurgan, nasihatni qulog’iga olmaydurgan, har xil buzuq ishlarni qiladurgan, nodon, johil bir rasvoyi olam bo’lub qolur." 581 1014 W4281761797.pdf 3 10 separator 0.988405 ¶ 1016 1018 W4281761797.pdf 3 11 text 0.99904084 "Abdulla Avloniy tarbiyani tug’ulgan kundan boshlash kerakligini, aynan shu paytdan axloqimizni go’zal qilib borishimizni, zehnimizni ham ravshanlashtirishimizni “Turkiy guliston yoxud axloq” asarida aytib o’tgan." 1018 1237 W4281761797.pdf 3 12 separator 0.9498135 ¶ 1238 1240 W4281761797.pdf 3 13 text 0.99945974 "Bundan tashqari, “Tarbiyani inson qayerdan olishi kerak”, - degan savolga birinchi navbatda, uydan olish kerakligini va farzandiga tarbiya berish, avvalo, onaning vazifasi ekanligini ta’kidlagan. Kishiga onaning tarbiyasidan tashqari maktab va madrasaning tarbiyasi ham, bundan tashqari tarbiya beri sh otaning, muallimning, mudarrisning va hukumatning ham vazifasi ekanligini aytgan." 1240 1638 W4281761797.pdf 3 14 separator 0.99079335 ¶ 1640 1642 W4281761797.pdf 3 15 text 0.9981336 "Yoshlarga ma’naviyatning ma’no -mazmunini, uning inson va jamiyat hayotidagi o’rni va ahamiyatini tushintirishga, ruhiy -ma’naviy oziq berish, dunyoqarashini yuksaltirishga xizmat qiladi. Maktablarda ham o’quvchilarning tarbiyasini yaxshilashga, ularni namunali xulqqa, axloqiy sifatlarini rivojlantirishga yo’naltiruvchi turli anjumanlar, davra suhbatlari, bahs - munozaralar, uchrashuvlar uyushtirish, ma’naviy tarbiyaning mazm un- mohiyatini o’quvchilarga tushunarli tarzda izohlab beradigan qo’llanma va tavsiyalar tayyorlash kerak. Xulosa qilib aytganda, yoshlarni yuqorida ko’rsatilgan usullar yordamida ma’naviy -ma’rifiy ruhda tarbiyalash barkamol avlodni shakllantirishdagi muamm olarni bartaraf etishi mumkin." 1642 2389 W4281761797.pdf 3 16 separator 0.99702954 ¶ 2391 2393 W4281761797.pdf 3 0 paratext 0.9652329 "152 ¶ PRESUMPTION of LAW Fakultas Hukum Universitas Majalengka Volume 5 Nomor 2, Oktober 2023" 0 107 W4388044077.pdf 6 1 separator 0.7423529 "¶ ¶ " 109 121 W4388044077.pdf 6 2 text 0.36881027 e. Menetapkan 121 134 W4388044077.pdf 6 3 bibliography 0.35463315 Terdakwa 135 144 W4388044077.pdf 6 4 text 0.36184192 membayar biaya perkara sej 144 173 W4388044077.pdf 6 5 bibliography 0.3018443 umlah 173 178 W4388044077.pdf 6 6 text 0.41380596 Rp2.000,- 179 189 W4388044077.pdf 6 7 separator 0.75665164 ¶ 191 193 W4388044077.pdf 6 8 text 0.50956076 (dua ribu rupiah). 193 212 W4388044077.pdf 6 9 separator 0.99335915 ¶ ¶ 214 221 W4388044077.pdf 6 10 title 0.96671885 "2. Pertimbangan Hakim Dalam Menjatuhkan Putusan Perkara Tindak Pidana Penganiyaan Terhadap Anggota TNI Berdasarkan Putusan Nomor: 359/Pid.B/2022/PN Tjk" 221 390 W4388044077.pdf 6 11 separator 0.9950836 ¶ 391 393 W4388044077.pdf 6 12 text 0.99901354 "Musyawarah hakim pada mengambil suatu putusan merupakan salah satu unsur penting pada menegakkan suatu putusan, sebab musyawarah merupakan aspek penting berasal segala aspek putusan, bahkan putusan tak cukup memuat musyawarah menjadi alasan untuk diberikannya pengajuan pulang. Upaya hukum, baik banding juga kasasi, mengakibatkan putusan berpotensi dibatalkan oleh pengadilan lebih tinggi ." 394 833 W4388044077.pdf 6 13 separator 0.95942533 ¶ 834 836 W4388044077.pdf 6 14 text 0.9988446 "Pada pemeriksaan perkara, hakim wajib memperhatikan alat bukti, sebab hasil pembuktian nantinya dipergunakan menjadi bahan pemeriksaan perkara. Pembuktian merupakan tahapan sidang pengadilan sangat penting, pembuktian bertujuan untuk menerima kepastian bahwa suatu peristiwa fakta dituduhkan benar terjadi guna memperoleh putusan benar serta adil dari hakim. Hakim takakan bisa merogoh putusan hingga jelas baginya bahwa peristiwa fakta benar terjadi, yakni kebenarannya terbukti sebagai akibatnya tampak adanya hubungan hukum antara para pihak." 836 1451 W4388044077.pdf 6 15 separator 0.989805 ¶ 1453 1455 W4388044077.pdf 6 16 text 0.9986013 "Sesuai wawancara penulis dengan ibu Aria Verronica7, hakim pada Pengadilan Negeri Tanjungkarang, berkata bahwa pertimbangan hakim pada putusan kasus nomor 359/Pid.B/2022/PN Tjk dilakukan oleh terdakwa Rachmad Ardian Saputra Bin Diansyah F Nata benar. Bisa dilihat bahwa hakim wajib mendasarkan putusannya pada bukti , unsur serta pertimbangan cermat, pada terdakwa Rachmad Ardian Saputra Bin Diansyah F. Nata benar serta terbukti melakukan penganiayaan yang melanggar hukum terhadap Anggota. Selain faktor lain yang dikemukakan hakim dalam perkara tersebut, TNI adalah sebagai berikut:" 1455 2099 W4388044077.pdf 6 17 separator 0.7254051 ¶ 2101 2103 W4388044077.pdf 6 18 text 0.99509126 "a. Menimbang bahwa sesuai dengan Pasal 352(1) KUHP, Jaksa Penuntut Umum mendakwa terdakwa dengan satu dakwaan yang mengandung unsur -unsur sebagai berikut: 1) Komponen siapa 2) Komponen menganiaya seseorang; b. Menimbang bahwa pada saat terdakwa sedang mengamen, tidak ada pengunjung yang menawarkan uang; malah saksi Mufti Akbar Rafzanjani memberikan uang kepada terdakwa sebesar Rp. 2000, yang tidak diterima oleh terdakwa hingga terdakwa memeriksa saksi Muft i Akbar Rafzanjani; Menimbang, bahwa pada saat terjadi perkelahian antara Terdakwa dengan saksi Mufti Akbar Rafzanjani serta teman saksi Mufti Akbar Rafzanjani berbadan besar; c. Menimbang bahwa pada saat terjadi perkelahian antara terdakwa dengan saksi Mufti Akbar Rafzanjani dengan teman saksi Mufti Akbar Rafzanjani bertubuh tinggi ;" 2103 2975 W4388044077.pdf 6 19 separator 0.97966087 ¶ ¶ 2977 3041 W4388044077.pdf 6 20 paratext 0.80051655 7 3041 3043 W4388044077.pdf 6 21 title 0.8137418 Hasil wawancara dengan H akim pada Pengadilan Negeri Tanjungkarang 3043 3110 W4388044077.pdf 6 0 paratext 0.97271496 "Atmos. Chem. Phys., 10, 209– 218, 2010 www.atmos-chem-phys.net/10/209/2010/ © Author(s) 2010. This work is distributed under the Creative Commons Attribution 3.0 License." 0 176 W2005256698.pdf 0 1 separator 0.9849299 ¶ 176 178 W2005256698.pdf 0 2 title 0.9703777 "Atmospheric Chemistry and Physics" 178 216 W2005256698.pdf 0 3 separator 0.86167854 ¶ 216 218 W2005256698.pdf 0 4 title 0.97981787 Aerosols that form subvisible cirrus at the tropical tropopause 218 282 W2005256698.pdf 0 5 separator 0.9857639 ¶ 282 284 W2005256698.pdf 0 6 contact 0.63694143 K. D. Froyd1,2, D. M. Murphy1, P. Lawson3, D. Baumgardner4, and R. L. Herman5 284 362 W2005256698.pdf 0 7 separator 0.9522608 ¶ 362 364 W2005256698.pdf 0 8 contact 0.9899869 "1NOAA Earth System ResearchLaboratory, Chemical Sciences Division, Boulder, CO, USA 2Cooperative Institute for Research in Environmental Science, University of Colorado, Boulder, CO, USA 3SPEC Incorporated, Boulder, CO, USA 4Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico City, Mexico 5Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA, USA" 364 762 W2005256698.pdf 0 9 separator 0.9173341 ¶ 762 764 W2005256698.pdf 0 10 paratext 0.96725965 "Received: 11 September 2009 –Published in Atmos. Chem. Phys. Discuss.: 29 September 2009 Revised: 16 December 2009 – Accepted: 17 December 2009 – Published: 12 January 2010" 764 939 W2005256698.pdf 0 11 separator 0.99459827 ¶ 939 941 W2005256698.pdf 0 12 text 0.9936644 "Abstract. The composition of residual particles from evap- orated cirrusice crystalsnear the tropical tropopause as well as unfrozen aerosols were measured with a single particle massspectrometer. Subvisiblecirrusresidualswerepredom- inantly composed of internal mixtures of neutralized sulfate with organic material and were chemically indistinguishable from unfrozen sulfate-organic aerosols. Ice residuals were also similar in size to unfrozen aerosol. Heterogeneous ice nuclei such as mineral dust were not enhanced in these sub- visible cirrus residuals. Biomass burning particles were de- pleted in the residuals. Cloud probe measurements showing low cirrus ice crystal number concentrations were inconsis- tent with conventional homogeneous freezing. Recent lab- oratory studies provide heterogeneous nucleation scenarios that may explain tropopause level subvisible cirrus forma- tion." 941 1865 W2005256698.pdf 0 13 separator 0.99646056 ¶ 1865 1867 W2005256698.pdf 0 14 title 0.9780706 1 Introduction 1867 1882 W2005256698.pdf 0 15 separator 0.9949869 ¶ 1882 1884 W2005256698.pdf 0 16 text 0.9964594 "Optically thin cirrus are a common feature of the tropical troposphere layer (TTL) (Fueglistaler et al., 2009; Dessler et al., 2006; Liu, 2007). Cirrus with very low optical den- sities ( τ<0.03), often termed subvisible cirrus (SVC), are widespread laminar features that occur primarily in the trop- ical tropopause region. SVC can form in situ (Pfister et al., 2001; Schwartz and Mace, 2009) or as a consequence of recent convection (Dessler and Yang, 2003; Garrett et al., 2004; Massie et al., 2002). These cirrus regulate the vertical " 1884 2439 W2005256698.pdf 0 17 separator 0.81785494 ¶ 2439 2440 W2005256698.pdf 0 18 contact 0.93513346 "Correspondence to: K. D. Froyd (Karl.Froyd@noaa.gov)" 2440 2495 W2005256698.pdf 0 19 bibliography 0.41332722 transport 2495 2504 W2005256698.pdf 0 20 text 0.6107643 of water vapor 2504 2519 W2005256698.pdf 0 21 bibliography 0.743458 "(Jensen and Pfister, 2004; Jensen et al., 1996; Luo et al., 2003" 2519 2585 W2005256698.pdf 0 22 text 0.8873458 ") as well as aerosols and condens- able gases into the stratosphere. The radiative properties of thin cirrus can influence the local thermal budget and drive dynamics of the tropopause region (Comstock et al., 2002; Hartmann et al., 2001; Jensen et al., 1996; McFarquhar et al., 2000)." 2585 2879 W2005256698.pdf 0 23 separator 0.9515163 ¶ 2879 2881 W2005256698.pdf 0 24 text 0.9973165 "Knowledge of SVC formation mechanisms is hampered by limited field observations of aerosol size, composition, and ice-forming capability in the tropical upper troposphere." 2881 3056 W2005256698.pdf 0 25 separator 0.88936806 ¶ 3056 3058 W2005256698.pdf 0 26 text 0.9989906 "Relative humidities well above ice saturation are frequently foundinclearairinthetropicaltropopauseregionandimply a shortage of effective heterogeneous ice nuclei (IN). Fur- thermore, measured relative humidities near the tropopause (185–204K) are often near or may exceed levels required for homogeneous freezing of soluble aerosols (Jensen et al., 2005;Kr ̈ameretal.,2009). Theonsetofhomogeneousfreez- ing would convert a large fraction of accumulation mode aerosols to ice crystals and would be largely independent of aerosol composition. However, in simulations of SVC for- mation, introducing small concentrations of heterogeneous IN more accurately reproduced thin cirrus occurrence, per- sistence, and microphysical properties (Jensen et al., 2001, 2008; Karcher, 2002, 2004). Jensen et al. (2009b) ana- lyzed recent measurements of tropopause level SVC crystal sizes and concentrations using a parcel model and evaluated probable nucleation scenarios. A summary of microphysical properties of SVC is given by Lawson et al. (2008)." 3058 4130 W2005256698.pdf 0 27 separator 0.96538854 ¶ 4130 4132 W2005256698.pdf 0 28 text 0.9983663 "Single particle information is particularly important for studying ice nucleation since the onset of freezing can vary greatly for different aerosol types that are often externally mixed. Also, direct measurement of ice crystal residue is criticaltodeterminingnucleationmechanisms. Forinstance, " 4132 4436 W2005256698.pdf 0 29 separator 0.74149036 ¶ 4436 4437 W2005256698.pdf 0 30 text 0.5825444 4437 4438 W2005256698.pdf 0 31 paratext 0.649588 Published by 4438 4450 W2005256698.pdf 0 32 text 0.5172707 Co 4450 4453 W2005256698.pdf 0 33 paratext 0.7322336 pernicus Publications on behalf of the European Geosciences Union. 4453 4519 W2005256698.pdf 0 0 paratext 0.9798583 14203 0 5 W4323352567.pdf 13 1 title 0.69841146 Discussion 5 16 W4323352567.pdf 13 2 separator 0.9876071 ¶ 17 19 W4323352567.pdf 13 3 text 0.9977403 "204 Our study showed that aerobics and weight training have beneficial effects on IHD. Without 205 the US guidelines for physical activity, there was a high level of heterogeneity in the effects 206 of physical activity by type, with overall effects of 0.764 (OR; 95% CI: 0.737–0.795). No 207 publication bias was observed. However, after applying the US guidelines for physical 208 activity, there was a low level of heterogeneity in its effects and an observed OR of 0.515 209 (95% CI: 0.401–0.662) for MI. A significant reduction in the heterogeneity of the studies 210 after applying the US guidelines suggests that these recommend certain levels of exercise 211 intensity and include the duration of exercise irrespective of the types of exercise. There was 212 no significant difference among countries. In a previous related study, increased physical 213 activity was found to be associated with lower blood pressure in hypertensive individuals, 214 increased high-density lipoprotein cholesterol levels in a dose-response manner, and reduced 215 incidence of diabetes [29]. The health benefits of physical activity can be achieved by 216 engaging in moderate-intensity physical activity (brisk walking) for at least 30 min per day, 5 217 days per week, or vigorous activity (jogging) for 20 min or more, 3 days per week." 19 1387 W4323352567.pdf 13 4 separator 0.67364097 ¶ 1388 1390 W4323352567.pdf 13 5 text 0.9988432 "218 Combinations of the two types of activity can also be performed. Furthermore, a mendelian 219 randomization study reported that genetically predicted self-reported vigorous physical 220 activity was significantly associated with a lower risk of MI (OR: 0.24, 95% CI: 0.08–0.68; 221 p-value: 0.007) [30]. Additionally, those results were consistent after the sensitivity analysis." 1390 1783 W4323352567.pdf 13 6 separator 0.91238266 ¶ 1784 1786 W4323352567.pdf 13 7 text 0.9980774 "222 The INTERHEART study demonstrated that regular exercise reduced the risk of MI (OR: 223 0.86) [31]. A different study, which followed 84,129 women who engaged in moderate or 224 vigorous exercise for over 30 min per day, reported a relative risk of 0.17 [32]." 1786 2056 W4323352567.pdf 13 8 separator 0.8187431 ¶ 2056 2058 W4323352567.pdf 13 9 text 0.9734707 "225 The strength of the current study was that the beneficial effects of physical activity on 226 cardiovascular health were reported with the US guidelines for physical activity. The level," 2058 2252 W4323352567.pdf 13 10 paratext 0.95399076 . CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)The copyright holder for this preprint this version posted March 7, 2023. ; https://doi.org/10.1101/2023.03.06.23286885doi: medRxiv preprint 2253 2593 W4323352567.pdf 13 0 paratext 0.8990402 132 J. Park et al.: EPB in TEC 0 30 W2172206941.pdf 3 1 separator 0.9937378 ¶ 30 32 W2172206941.pdf 3 2 caption 0.9880207 "Figure 3. Polar plots showing TEC fluctuation level as a func- tion of co-elevation and azimuth angles of GNSS satellites as seen from CHAMP: (a)northern low-latitude region (between C5 and C25N),(b)equatorial region (between" 32 264 W2172206941.pdf 3 0 paratext 0.99022436 Animals 2023 ,13, 2323 4 of 13 0 30 W4384557995.pdf 3 1 separator 0.99542457 ¶ 30 32 W4384557995.pdf 3 2 text 0.9989771 "Beta diversity was computed using the Bray–Curtis distance method and plotted with a principal component analysis (PCoA) using a ggplot2 R package [42]." 32 187 W4384557995.pdf 3 3 separator 0.6292535 ¶ 187 189 W4384557995.pdf 3 4 text 0.9989103 "Differential analysis was performed using the DESeq2 package in R [ 43] and the differences between breeds and diets were analyzed in separate models (Table 2) as reported by López-Garc ía et al. [ 13]. The visualization of detected differences was made using the EnhancedVolcano package in R [44]." 189 494 W4384557995.pdf 3 5 separator 0.99688375 ¶ 494 496 W4384557995.pdf 3 6 title 0.8764011 Table 2. DESeq2 differential abundance models for each contrast. 496 561 W4384557995.pdf 3 7 separator 0.9938765 ¶ 561 563 W4384557995.pdf 3 8 title 0.84719193 Contrast Model Design 563 585 W4384557995.pdf 3 9 separator 0.55675477 ¶ 585 587 W4384557995.pdf 3 10 table 0.7221137 "Breed contrast Diet + Breeds Interaction effects in crossbred Diet + Time + Diet: Time Interaction effects in Nero Siciliano Diet + Time + Diet: Time" 587 741 W4384557995.pdf 3 11 separator 0.995893 ¶ 741 743 W4384557995.pdf 3 12 title 0.9916471 2.5. Statistical Analysis 743 769 W4384557995.pdf 3 13 separator 0.9963595 ¶ 769 771 W4384557995.pdf 3 14 text 0.9928589 "To evaluate the distribution of alpha diversity, based on the Shannon index, a one-way nonparametric Wilcoxon test was used for diet and breed variables, while the nonparamet- ric Kruskal–Wallis test was employed for the time variable. " 771 1012 W4384557995.pdf 3 15 separator 0.50006145 ¶ 1012 1013 W4384557995.pdf 3 16 text 0.99909115 "The PCoA, which evaluates the differences between samples based on the Bray– Curtis distance, was assessed through permutational multivariate analysis of variance (PERMANOVA) with 999 permutations using the vegan package [45]." 1013 1244 W4384557995.pdf 3 17 separator 0.6692141 ¶ 1244 1246 W4384557995.pdf 3 18 text 0.9988945 "The differences produced during the differential analysis were determined by a Wald test p-value and were considered statistically significant using a false discovery rate (FDR) cut-off of 0.05 and a fold-change (FC) higher than 1.5 or lower than" 1246 1496 W4384557995.pdf 3 0 paratext 0.9750368 1 0 1 W2768818596.pdf 0 1 separator 0.87645763 ¶ 1 3 W2768818596.pdf 0 2 paratext 0.94303906 "Content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI." 3 239 W2768818596.pdf 0 3 separator 0.5547017 239 240 W2768818596.pdf 0 4 paratext 0.9699114 "¶ Published under licence by IOP Publishing Ltd 123456789028th Micromechanics and Microsystems Europe Workshop IOP Publishing IOP Conf. Series: Journal of Physics: Conf. Series 922 (2017) 012007 doi :10.1088/1742-6596/922/1/012007" 240 476 W2768818596.pdf 0 5 separator 0.7456019 "¶ ¶ ¶ ¶" 477 499 W2768818596.pdf 0 6 title 0.9835714 Smart design piezoelectric energy harvester with self -tuning 499 562 W2768818596.pdf 0 7 separator 0.97536355 ¶ 564 566 W2768818596.pdf 0 8 contact 0.9848998 "L G H Staaf1, E Köhler1, P D Folkow2, P Enoksson1 1 Department of Microtechnology and Nanoscience, Chalmers University of Technology, Gothenburg, Sweden 2 Division Dyanmics, Chalmers University o f Technology, Gothenburg, Sweden V96staaf@chalmers.se" 566 830 W2768818596.pdf 0 9 separator 0.9964783 ¶ 832 834 W2768818596.pdf 0 10 text 0.5923381 Abstract 834 843 W2768818596.pdf 0 11 separator 0.9196582 843 844 W2768818596.pdf 0 12 text 0.9988821 ". Piezoelectric energy harvesting on a gas turbine implies constraints like high temperature tolerance, size limitation and a particular range of vibrations to utilise. In order to be able to op erate under these conditions a harvester needs to be space effective and efficient and to respond to the appropriate range of frequencies. We present the design, simulation and measurements for a clamped -clamped coupled piezoelectric harvester with a free -sliding weight , which adds self -tuning for improved response within the range of vibrations from the gas turbine. We show a peak open circuit voltage of 11.7 V and a 3 dB bandwidth of 12 Hz." 844 1509 W2768818596.pdf 0 13 separator 0.997304 ¶ 1511 1513 W2768818596.pdf 0 14 title 0.98784566 1. Introduction 1513 1530 W2768818596.pdf 0 15 separator 0.99544513 ¶ 1532 1534 W2768818596.pdf 0 16 text 0.9970195 "The coming of the internet of things requires that we now develop alternative energy sources to replace or support today's and tomorrow's batteries. Alternative energy sources such as energy harvesters have been focused on by many researchers during the past years [1]. Energy harvesters convert ambient energy i n our surrounding, like solar irradiation, wind, heat and mechanical vibrations into electric energy. For a gas turbine the main ambient energies are heat and mechanical vibrations. The thermal energy is concentrated to certain areas within the gas turbine , while vibrations are more or less available everywhere, making piezoelectric energy harvesting a viable option. The main challenge for piezoelectric energy harvesting is to maintain a sufficient power output over a broad bandwidth; much research has been done on broadening the harvesting bandwidth [1 -2]" 1534 2438 W2768818596.pdf 0 17 separator 0.9318404 ¶ 2439 2441 W2768818596.pdf 0 18 text 0.9996163 "In this paper we report on the design, simulation and measurements of a piezoelectric harvester with self-tuning for wider bandwidth and coupled piezoelectric cantilevers to maintain a high power output by extended strain distribution. The harvester is designed to meet the gas turbine s specific conditions on size, temperature and frequency. Previous work [3] has shown that by utilizing a distributed stress pattern over the whole cantilever , the complete area of the piezoelectric cantilever is used and not only the clamped end, thereby yielding a higher power output. In previous work [4] this distributed stress pattern was observed for a cantilever with one end fixed and the other end coupled to a second (top) cantilever (which showed a stress pattern similar to a single cantilever with one end fixed). In the present design both cantilevers are clamped and coupled at each end, hence using all available piezoelectric capacity to optimize the power output. To ext end the bandwidth, passive self -tuning is introduced by a free sliding weight. In previous work a free sliding proof mass has been used on a thin fixed -fixed beam . When the proof mass slides to one end of the thin beam it can get stuck there even if" 2441 3707 W2768818596.pdf 0 0 text 0.99871016 "occur. As an ‘alternative ’way, ‘self-re flection ’was commonly referred to by some crew as the ‘substitute ’for reporting. For example, a chief of ficer said:132 C. Xue" 0 169 W3107351698.pdf 5 1 separator 0.9882593 ¶ 169 171 W3107351698.pdf 5 2 text 0.9995509 "It was rare (to report). If you reported to the company, it would cause trouble. But in reality, we would not report. It would be digested on board unless it had serious consequences." 171 357 W3107351698.pdf 5 3 separator 0.9474294 ¶ 357 359 W3107351698.pdf 5 4 text 0.99960434 "Fear of ‘trouble ’(for the whole crew and not simply the individual reporting an incident) was suggested as a reason for underreporting and this will be returned to in due course. In C1, in order to encourage more reporting of near misses, a box was placed in public places on the two ships. During my time on board, questions were raised about how individual crew contributed to the near-miss box. The inter- viewees ’reaction seemed to vary, some gave awkward smiles and some were unwilling to talk about their own experiences, just giving a super ficial answer saying that it was the company ’s requirement. However a second of ficer gave a clear and firm response, ‘it was empty ...nobody care about it ’. This general impression showed that commitment to submitting reports to the near miss box remained weak (notwithstanding the super ficial anonymity it provided1)." 359 1248 W3107351698.pdf 5 5 separator 0.9823752 ¶ 1248 1250 W3107351698.pdf 5 6 text 0.999286 "The discussion in this section shows that underreporting of shipboard accidents and near-misses was common. Few safety-related problems were reported unless there was a signi ficant consequence with which the crew could not cope without shore support." 1250 1507 W3107351698.pdf 5 7 separator 0.9948219 ¶ 1507 1509 W3107351698.pdf 5 8 title 0.99340856 Biased Reporting and Underlying Social Factors 1509 1556 W3107351698.pdf 5 9 separator 0.99493176 ¶ 1556 1558 W3107351698.pdf 5 10 text 0.9997054 "Not only did this study find considerable under-reporting of accidents and near- misses, it also found that the reporting in both companies could be biased in one way or another. It seemed that the crew, particularly the senior of ficers, would carefully deliberate as to what to state prior to giving any account to their companies. Their ‘general principles ’appeared to be to focus on trivial matters so that some matters could be reported as required by the company without re flecting badly on the crew." 1558 2074 W3107351698.pdf 5 11 separator 0.8637947 ¶ 2074 2076 W3107351698.pdf 5 12 text 0.9930505 "One suggested that: Basically for us, the principle of reporting is to report only the good not the bad, to avoid the critical points and dwell on the trivial (Captain). We had certain consideration ...The ship could not report all the issues [to the company]. Also, [the ship] could not report nothing. [So] some innocuous cases might be reported (Chief Of ficer)." 2076 2451 W3107351698.pdf 5 13 separator 0.97163874 ¶ 2451 2453 W3107351698.pdf 5 14 text 0.9993016 "Reported incidents demonstrated that the crew tended to report ‘innocuous ’cases or‘something unimportant ’to their companies. For example, a chief of ficer said:" 2453 2617 W3107351698.pdf 5 15 separator 0.8489324 ¶ 2617 2619 W3107351698.pdf 5 16 text 0.63522637 1Crews are so small and subdivided in terms of role 2619 2671 W3107351698.pdf 5 17 bibliography 0.5296602 and 2671 2675 W3107351698.pdf 5 18 text 0.57251644 department 2675 2686 W3107351698.pdf 5 19 bibliography 0.45133904 that 2686 2691 W3107351698.pdf 5 20 text 0.58072484 it is unlikely 2691 2706 W3107351698.pdf 5 21 bibliography 0.46013203 that 2706 2711 W3107351698.pdf 5 22 text 0.45911747 2711 2712 W3107351698.pdf 5 23 bibliography 0.5480112 ¶ anonym 2712 2720 W3107351698.pdf 5 24 text 0.5511899 ity could in 2720 2732 W3107351698.pdf 5 25 bibliography 0.49859762 fact 2732 2737 W3107351698.pdf 5 26 text 0.59204656 prevail. 2737 2746 W3107351698.pdf 5 0 paratext 0.9673057 "Videtta et al. 10.3389/fpsyt.2023.1335706 Frontiers in Psychiatry 04 frontiersin.org" 0 86 W4391444229.pdf 3 1 title 0.98502463 TABLE 1 Sociodemographic and clinical variables of reviewed studies. 86 155 W4391444229.pdf 3 2 separator 0.993631 ¶ 155 157 W4391444229.pdf 3 3 table 0.9824509 "Study Study designSample size (M/F)Age (mean ± sd)Clinical treatment DTI parameters Main results Antidepressant medicationsDosageLength of therapyAcquisition (Tesla, direction, voxel—mm3)IndicesClinical outcomeWM integrity Alexopoulos et al. ( 29)Cross- sectionalMDD: 48 (ns/ns) 70.2 ± 5.8 Escitalopram 10 mg/dd 12 wk 1.5 T, 8, 5 × 5 × 5 FA • Remitters (25) • Non-remitters (23)↑FA ACC, DLPFC, genu (CC), hippocampus, PCC, insula." 157 643 W4391444229.pdf 3 4 separator 0.81690013 ¶ 643 645 W4391444229.pdf 3 5 table 0.9918745 "Davis et al. (30)Cross- sectionalMDD: 165 (61/104)35.7 ± 12.5 Escitalopram 10-20 mg/dd •2 wk. •8 wk• 3.0 T, 30, 2.5 × 2.5 × 2.5 • 3.0 T, 31, 2.5 × 2.5 × 2.5• FA • MD • AD • RD• Responders (80) • Non-responders (85)↓AD bilateral cerebral peduncle, L PTR, R CgC, bilateral CgH, L EC." 645 959 W4391444229.pdf 3 6 separator 0.9165888 ¶ 959 961 W4391444229.pdf 3 7 table 0.9937021 "Dong et al. (31)Cross- sectionalMDD: 127 (58/69) 35.3 ± 9.1 • SSRI • SNRIns 24 wk 3.0 T, 32, 3 × 3 × 3 FA • Remitters (62) • Non-remitters (65)NS FA." 961 1120 W4391444229.pdf 3 8 separator 0.7304404 ¶ 1120 1122 W4391444229.pdf 3 9 table 0.99495417 "Hoogenboom et al. ( 32)Cross- sectionalMDD: 92 (34/58) 46.5 ± 14.6 • SSRI • NDRI • SNRI • TCA • Lithium • NaSSA • SARIns 12 mo • 1.5 T, 7, 6 x 6 x 6 • 1.5 T, 16, 6 × 6 × 6 • 1.5 T, 22, 6 × 6 × 6 • 1.5 T, 23, 6 × 6 × 6 • 1.5 T, 28, 6 × 6 × 6 • 1.5 T, 35, 6 × 6 × 6 • 1.5 T, 39, 6 × 6 × 6 • 1.5 T, 70, 6 x 6 x 6FA • Remitters (63) • Non-remitters (29)↑FA medial fornix." 1122 1523 W4391444229.pdf 3 10 separator 0.9468383 ¶ 1523 1525 W4391444229.pdf 3 11 table 0.9919796 "Korgaonkar et al. ( 33)Cross- sectionalMDD: 80 (40/40) 33.8 ± 13.1 • Escitalopram • Sertraline • Venlafaxine-XR• 10-20 mg/dd (Escitalopram) • 50-200 mg/dd (Sertraline) • 75-225 mg/dd (Venlafaxine-XR)8 wk 3.0 T, 42, 2.5 × 2.5 × 2.5 FA • Remitters (37) • Non-remitters (43)↑FA CgC. ↓FA stria terminalis." 1525 1856 W4391444229.pdf 3 12 separator 0.89008176 ¶ 1856 1858 W4391444229.pdf 3 13 table 0.99291605 "Pillai et al. ( 34) Cross- sectionalMDD: 144 (54/90) 37.2 ± 13.7 Sertraline 200 mg/dd (maximum dose)8 wk • ns, 64, 2.5 × 2.5 × 2.5 • ns, 64, 1.9 × 1.9 × 1.9• FA • MD • AD • RD• Remitters (53) • Non-remitters (91)↓FA WM tracts raphe nucleus- bilateral amygdala." 1858 2139 W4391444229.pdf 3 14 separator 0.53345716 2139 2140 W4391444229.pdf 3 15 table 0.91598046 ¶ (Continued) 2140 2153 W4391444229.pdf 3 0 paratext 0.98215514 K. Ziegert et al. 0 18 W2144652881.pdf 2 1 separator 0.90832114 "¶ ¶" 20 30 W2144652881.pdf 2 2 text 0.9960563 "1889 examined separately. The bedside test consists of a clinical examination that can be performed in any care unit as long as the requirements correspond to the competence and qualifications required of a registered nurse." 30 259 W2144652881.pdf 2 3 separator 0.9796545 ¶ 260 262 W2144652881.pdf 2 4 text 0.9996306 "Testing students ’ bedside performance provides an opportunity to evaluate how their theoretical knowledge is applied in practice (Meah et al. , 2009) . During the bedside part of their annual clinical placement, the students take care of a patient in need of comprehensive medical and nursing care. The clinical placement may involve inpatient care (hospital care) or outpatient care (community care). The choice of patient is decided upon after careful joint consideration between the student and clinical lecturer. The patient must give his or her informed consent. During the examination, the student is observed by nurse, who is guided by a structured assessment tool that reflects the areas of competence required by registered nurses. The bedside test has a clear structur e and consists of three ste ps: 1) assessment of needs and pr oblems, analyses and planning; 2) implementation and evaluation of nursing activities ; 3) reflections and final judgment. In the third step the student reflects on steps one and two together with the RN and a clinical lecturer. Based on the scores in the assessment tool and the nurse ’s oral report, the clinical lecturer decides whether the student has passed or failed the bedside examin a- tion." 262 1536 W2144652881.pdf 2 5 separator 0.9862683 ¶ 1537 1539 W2144652881.pdf 2 6 text 0.9997118 "In a previous paper we described how nursing students experienced being assessed by the NCFE (Andersson et al. , 2012) , where the students ’ considered the interactive approach of the written test, in which the correct answer given on the next page, contributes to their learning, and the NCFE, especially the written par t, made them reconsider their education as a whole. The aim of this study was to investigate the experiences of the NCFE from lecturers who corrected the written part of examination. A further aim was to study the lectures and the RN during observation of the bedside part of the examination." 1539 2175 W2144652881.pdf 2 7 separator 0.9967098 ¶ 2177 2179 W2144652881.pdf 2 8 title 0.9904604 3. Methods 2179 2190 W2144652881.pdf 2 9 separator 0.9944806 ¶ 2192 2194 W2144652881.pdf 2 10 title 0.99104935 3.1. Study Design 2194 2212 W2144652881.pdf 2 11 separator 0.9950887 ¶ 2214 2216 W2144652881.pdf 2 12 text 0.9996265 The design of the study was a descriptive, qualitative design. In this study the focus was on the experiences on the use of the NCFE in for a Swedish Bachelor of Sciences in Nursing. 2216 2399 W2144652881.pdf 2 13 separator 0.9969551 ¶ 2401 2403 W2144652881.pdf 2 14 title 0.9910048 3.2. Ethical Consideration 2403 2430 W2144652881.pdf 2 15 separator 0.99427474 ¶ 2432 2434 W2144652881.pdf 2 16 text 0.9996974 "All ethical issues were considered and harm minimised by following the guiding ethical and as the study did not fall under the Swedish Act concerning Ethical Review of Research Involving Humans (SFS, 2008: p. 192), no ethical permission was sought. The participants were fully informed about the voluntary nature of participation, how the data would be treated and the procedures ensuring confidentiality. Informed written consent was o b- tained from all pa rticipant s and all participants were informed that they could withdraw from the study at any time without consequences." 2434 3030 W2144652881.pdf 2 17 separator 0.99703586 ¶ 3032 3034 W2144652881.pdf 2 18 title 0.9905167 3.3. Data Collection 3034 3055 W2144652881.pdf 2 19 separator 0.9961626 ¶ 3057 3059 W2144652881.pdf 2 20 text 0.99965113 "Data were collected during two months through study -specific questionnaires that captured also responses to open -ended questions. The participants consisted of four groups: students , lecturers, clinical lecturers and nurses from 10 Swedish Universities collaborating in the NCFE ( Table 1 ). The questionnaire also included open- ended questions where the pa rticipants in this study were asked to describe their experiences of participa ting in both arts of the NCFE: 1) written part and 2) bedside part, and also views of the examinations tools." 3059 3622 W2144652881.pdf 2 21 separator 0.7592026 ¶ 3625 3627 W2144652881.pdf 2 22 text 0.9994583 In this study we selected from the study -specific questionnaire the participants ’ answers. 3627 3721 W2144652881.pdf 2 23 separator 0.9969592 ¶ 3723 3725 W2144652881.pdf 2 24 title 0.9911606 3.4. Data Analysis 3725 3744 W2144652881.pdf 2 25 separator 0.9965204 ¶ 3746 3748 W2144652881.pdf 2 26 text 0.9997498 "The text was subjected to qualitative content analysis (Gran eheim & Lundman, 2004) was used. The analysis started by reading the participants ’ answers as a means to acquire an understanding of the overall NCFE, as well as to capture essential features of the text. Relevant parts of the data included their experiences over time, a s- pects about the organisation and how it is to be an RN. The text w as read and re -read to build a general impre s- sion of the whole material and then sentences describing the participants ’ experiences of the examination were identified. Single words or short sentences were used for the coding of vignettes. Codes with a simi lar content were grouped into categories and outcomes formulated. In this step the main authors (KZ & PLA) condensed the" 3748 4557 W2144652881.pdf 2 0 text 0.9989627 "duration of the target dataset. As a next step, the [tar of each tuple in T is compared with the [ref of the reference movement pattern. If both PDP representa - tions match exactly irrespective of the temporal length, then the tuple is taken as a match of the one- point reference movement pattern. In this way, we found these six exact matches: Match-I (V2,V4,V5,V6), Match-II (V10CV11CV12CV13), Match- III (V24CV25CV26CV27), Match-IV (V31CV32CV33CV34), Match-V (V36CV37CV38CV39), and Match-VI (V43CV44CV45CV46). A static representation of these six matches is shown in Figures A1–A3 ." 0 619 W4281656749.pdf 9 1 separator 0.9838919 ¶ 619 621 W4281656749.pdf 9 2 text 0.9994059 "Each of these matches matched with the reference movement pattern during a specific interval irrespec - tive of its temporal length. This is because we have used the event-based approach where the time at which the event occurred is recorded for the analysis purposes. For instance, in Figure 7, Match-I (V2CV4CV5CV6) matched with the [ref of the one- point reference movement pattern from t26–t47. Note that these matches are found by checking whether the centroids of the vehicles lie inside the buffer zone Z in accordance with the one-point reference movement pattern." 621 1226 W4281656749.pdf 9 3 title 0.9883876 "4.4. Does the length of a vehicle matter Ganalysis with two points" 1226 1295 W4281656749.pdf 9 4 separator 0.9847323 ¶ 1295 1297 W4281656749.pdf 9 5 text 0.99954087 "A vehicle is an object with its own dimensions. These dimensions vary according to vehicle type and have a major impact on the probability and severity of crashes. That is why an important question is whether the length of the vehicles affects the process of finding the exact matches. We tried to answer this question by making a two-point reference movement pattern using the front-end (f) and the back-end (b) of the vehicles as shown in Figure 8(a). In this way, we captured the length of the vehicles and sought for the exact matches of this two-point reference movement pattern in the target dataset. The goal is to check if the six matches found for the one-point reference move - ment pattern remain the same for the two-point refer - ence movement pattern or whether considering two points results in different matches than considering a single point. A complete static representation of the two-point reference movement pattern is given in Figure A4." 1297 2310 W4281656749.pdf 9 6 separator 0.95664924 ¶ 2310 2312 W4281656749.pdf 9 7 text 0.9990514 "Certainly with two points, the representation [ref of the two-point reference movement pattern differs sig- nificantly from that of the one-point reference pattern." 2312 2482 W4281656749.pdf 9 8 separator 0.9958938 ¶ 2483 2485 W4281656749.pdf 9 9 caption 0.9947993 Figure 7. Match-I (V2CV4CV5CV6) for the one-point reference movement pattern.414 2485 2566 W4281656749.pdf 9 10 separator 0.99581814 ¶ 2566 2568 W4281656749.pdf 9 11 bibliography 0.92625964 A. QAYYUM ET AL. 2569 2586 W4281656749.pdf 9 0 paratext 0.70251614 Citation: El Hafda 0 18 W4313889722.pdf 0 1 bibliography 0.4891535 oui, 18 22 W4313889722.pdf 0 2 paratext 0.48698372 H. 22 25 W4313889722.pdf 0 3 bibliography 0.66432786 "; El Alaoui, H.; Mahidat, S.; El Harmouzi, Z.; ¶" 25 75 W4313889722.pdf 0 4 paratext 0.5773718 K 75 77 W4313889722.pdf 0 5 bibliography 0.49548712 halla 77 82 W4313889722.pdf 0 6 paratext 0.9284384 "ayoun, A. Impact of Hot Arid Climate on Optimal Placement of Electric Vehicle Charging Stations. Energies 2023 ,16, 753. https:// doi.org/10.3390/en16020753" 82 246 W4313889722.pdf 0 7 separator 0.62962645 ¶ 246 248 W4313889722.pdf 0 8 paratext 0.94528925 "Academic Editor: Tek Tjing Lie Received: 8 December 2022 Revised: 27 December 2022 Accepted: 3 January 2023 Published: 9 January 2023" 248 390 W4313889722.pdf 0 9 separator 0.5787166 ¶ 390 392 W4313889722.pdf 0 10 paratext 0.9551469 "Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)." 392 659 W4313889722.pdf 0 11 separator 0.8352992 ¶ 659 661 W4313889722.pdf 0 12 paratext 0.6516274 energies 661 670 W4313889722.pdf 0 13 separator 0.81581175 ¶ 670 672 W4313889722.pdf 0 14 title 0.96407825 Article 672 680 W4313889722.pdf 0 15 separator 0.48817003 ¶ 680 682 W4313889722.pdf 0 16 title 0.9886988 "Impact of Hot Arid Climate on Optimal Placement of Electric Vehicle Charging Stations" 682 770 W4313889722.pdf 0 17 separator 0.99115187 ¶ 770 772 W4313889722.pdf 0 18 contact 0.99130857 Hamza El Hafdaoui1,2,*, Hamza El Alaoui1, Salma Mahidat1, Zakaria El Harmouzi1and Ahmed Khallaayoun1 772 873 W4313889722.pdf 0 19 separator 0.72130656 ¶ 873 875 W4313889722.pdf 0 20 contact 0.98739564 "1School of Science and Engineering, Al Akhawayn University in Ifrane, Ifrane 53000, Morocco 2National School of Applied Sciences, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco *Correspondence: h.elhafdaoui@aui.ma" 875 1103 W4313889722.pdf 0 21 separator 0.99377763 ¶ 1103 1105 W4313889722.pdf 0 22 text 0.99903756 "Abstract: Electric vehicles (EVs) are becoming more commonplace as they cut down on both fossil fuel use and pollution caused by the transportation sector. However, there are a number of major issues that have arisen as a result of the rapid expansion of electric vehicles, including an inadequate number of charging stations, uneven distribution, and excessive cost. The purpose of this study is to enable EV drivers to find charging stations within optimal distances while also taking into account economic, practical, geographical, and atmospheric considerations. This paper uses the Fez-Meknes region in Morocco as a case study to investigate potential solutions to the issues raised above. The scorching, arid climate of the region could be a deterrent to the widespread use of electric vehicles there. This article first attempts to construct a model of an EV battery on MATLAB/Simulink in order to create battery autonomy of the most widely used EV car in Morocco, taking into account weather, driving style, infrastructure, and traffic. Secondly, collected data from the region and simulation results were then employed to visualize the impact of ambient temperature on EV charging station location planning, and a genetic algorithm-based model for optimizing the placement of charging stations was developed in this research. With this method, EV charging station locations were initially generated under the influence of gas station locations, population and parking areas, and traffic, and eventually through mutation, the generated initial placements were optimized within the bounds of optimal cost, road width, power availability, and autonomy range and influence. The results are displayed to readers in a node-link network to help visually represent the impact of ambient temperatures on EV charging station location optimization and then are displayed in interactive GIS maps. Finally, conclusions and research prospects were provided." 1105 3090 W4313889722.pdf 0 23 separator 0.9855865 ¶ 3090 3092 W4313889722.pdf 0 24 text 0.37323022 Keywords: electric vehicles; EV charging stations; location optimization; genetic algorithm; 3092 3185 W4313889722.pdf 0 25 paratext 0.26340893 ¶ 3185 3187 W4313889722.pdf 0 26 text 0.29560462 integer linear programming; 3187 3215 W4313889722.pdf 0 27 paratext 0.29053187 3215 3216 W4313889722.pdf 0 28 text 0.31313574 geographic 3216 3226 W4313889722.pdf 0 29 paratext 0.37761682 information systems 3226 3246 W4313889722.pdf 0 30 separator 0.9965788 ¶ 3246 3248 W4313889722.pdf 0 31 title 0.9865745 1. Introduction 3248 3264 W4313889722.pdf 0 32 separator 0.9952158 ¶ 3264 3266 W4313889722.pdf 0 33 text 0.9995523 "In recent years, electric vehicle sales have skyrocketed. They can use green energy to reduce their environmental impact. EV owners can also save money on gas due to generous subsidies offered by many countries to promote EV adoption [ 1]. The global EV market has grown rapidly due to these benefits." 3266 3573 W4313889722.pdf 0 34 separator 0.6022904 ¶ 3573 3575 W4313889722.pdf 0 35 text 0.99957734 "Range anxiety [ 2], the fear of running out of charge while driving, is one of the biggest obstacles to EV adoption [ 3–5]. Range anxiety is reduced by adding charging stations to a transportation network [ 6]. Enough en-route charging opportunities can reduce range anxiety for individual EV drivers by providing at least an energy-feasible path from origin to destination and a desired cost-minimization route." 3575 3996 W4313889722.pdf 0 36 separator 0.9216732 ¶ 3996 3998 W4313889722.pdf 0 37 text 0.9994612 "Charging stations are needed as more people buy alternative-fuel electric cars. Electric vehicle charging stations should be distributed optimally to meet demand. Since then, EV charging station placement has been studied extensively. This study has attracted taxi drivers [ 7–9], bus drivers [ 10], and EV owners. Price and consumer interest economists also contributed. Although the EV industry in many countries is large and promising," 3998 4445 W4313889722.pdf 0 38 separator 0.90594274 ¶ 4445 4447 W4313889722.pdf 0 39 paratext 0.9873111 Energies 2023 ,16, 753. https://doi.org/10.3390/en16020753 https://www.mdpi.com/journal/energies 4447 4544 W4313889722.pdf 0 0 paratext 0.9850628 280 AI & SOCIETY (2019) 34:269–287 0 34 W2785973954.pdf 11 1 separator 0.7778901 ¶ 34 36 W2785973954.pdf 11 2 paratext 0.98470056 1 3 36 40 W2785973954.pdf 11 3 separator 0.99318755 ¶ 40 42 W2785973954.pdf 11 4 text 0.9997419 "language of the “mental” and sees mind as embodied. But he also understood it as emerging from the interaction in a social context. In Experience and Nature (Dewey 1929) he sees knowledge as ‘a mode of interaction’ (435) and argues that meaning is not a ‘psychic existence’ (179). Dreyfus, focused on the handling of tools, ignores this more social-interactive view. But if we see technology as an instrument of social cooperation, as I proposed in my interpretation of Dewey’s view of language (Coeckelbergh 2017a, 33–37), then this puts tool use as skillful coping in a more social context. Moreover, whereas Dreyfus seems to put language in a separate category (the conceptual, the symbolical, etc.) divorced from embodied coping, for Dewey language is both embodied and social. It is about organized interaction with other living creatures (258). Second, Dreyfus could have used Dewey’s conception of habit. In Human Nature and Conduct ( 1922), Dewey argues that we know how by means of our habits (Dewey 1922, 177). This idea seems to fit Dreyfus’s account, and could help to understand our use of technology from a more social angle. Dreyfus talks about habit, but does not use Dewey to elaborate this social aspect of skillful coping. That coping and those skills can be under - stood as being part of habitual and shared ways of doing, and our tools become tools in the context of social groups (186). Third, Dewey’s work also seems particularly relevant when it comes to conceptualize public discussions about technology. In Dreyfus’s work, the public dimension is men-tioned but not theorized. Dewey could be used to elaborate this aspect of the social in a non-Hegelian way. But Dreyfus rejects this route. Here a significant barrier to using Dewey is that whereas Dewey stresses deliberation to solve social problems, for Dreyfus a lot is going on without deliberation. Moreover, Dreyfus seems to divorce mind and knowledge from the social. In his response to Collins (Dreyfus 1992, 724), Dreyfus argues that not all intelligence is social; this goes against the pragmatist view that intelligence is social and, again, is about solving social problems. (More below.) Finally, one could ask if Dreyfus’s account of skilled cop-ing is sufficiently appreciative of the social-linguistic and communicative dimension of coping. In my interpretation of Dewey, language must be seen as a social tool (Coeck - elbergh 2017a, 35). Perhaps language could be integrated in a Dreyfusian–Wittgensteinian view by saying that next to the handling of things, there is also skillful coping with words, and both kinds of skillful coping are always embed-ded in a social–practical context in which there is inexplicit knowledge but also language and language games, consti-tuting a form of life which is given and shapes our concrete coping-performances. And here, too, one could add that in the use of words, in coping using words, that language with-draws, is not always visible. Indeed, it is usually so invisible that Dreyfus managed to leave it out of his account of skill-ful coping. But this “default” invisibility does not justify excluding it from a theory about the kind of knowledge and experience involved in skilled coping." 42 3285 W2785973954.pdf 11 5 separator 0.98495895 ¶ 3285 3287 W2785973954.pdf 11 6 text 0.9992762 "But there are also possibilities next to using Dewey, that are certainly not far away at all from the thinking of Hei - degger and Merleau-Ponty, but that are, nevertheless, more appreciative of the social aspect of skill than Dreyfus was. For example, Borgmann, a philosopher of technology who in his praise of skilled activity is very close to Dreyfus, manages to connect skilled activity to the social in a very straightforward, less Heideggerian or mysterious way. He writes:" 3287 3772 W2785973954.pdf 11 7 separator 0.6495797 ¶ 3772 3774 W2785973954.pdf 11 8 text 0.9983316 ‘Physical engagement is not simply physical contact, but the experience of the world through the manifold sensibility of the body. Skill is intensive and refined world engagement. Skill, in turn, is bound up with social engagement. It molds the person and gives the person character.’ (Borgmann 1984, p. 42). 3774 4083 W2785973954.pdf 11 9 separator 0.9866847 ¶ 4083 4085 W2785973954.pdf 11 10 text 0.99965084 "Borgmann ( 1984 ) stresses that when we are engaged in skilled activity, we do not only engage with things but also with others, for example, when keeping a stove going cent-ers the family. A similar view can be found in Crawford’s analysis of craftsmanship, which is about working together and sharing a concept of good (Crawford 2009, 181). One could also argue that skilled activity helps us to shape our character. This takes us to the questions regarding virtue, and more generally the ethical and political implications of Dreyfus’s position." 4085 4637 W2785973954.pdf 11 11 separator 0.9958236 ¶ 4637 4639 W2785973954.pdf 11 12 title 0.98690873 "5 Problems with the ethical and political implications and the question regarding virtue" 4639 4735 W2785973954.pdf 11 13 separator 0.9938438 ¶ 4735 4737 W2785973954.pdf 11 14 text 0.9996244 "What are the ethical and political implications of Dreyfus’s view of skilled coping? While his account is mainly descrip-tive and aimed at understanding the kind of knowledge involved in skilled coping, it has normative implications. The problem is again that it is not entirely clear what these implications are based on Dreyfus’s own writings; but these implications need and deserve to be further articulated and developed, also with a view to arrive at a better thinking about technology." 4737 5233 W2785973954.pdf 11 15 separator 0.9739915 ¶ 5233 5235 W2785973954.pdf 11 16 text 0.99972516 "Like Reynolds (2006) I believe that if we look at his account of skill acquisition, Dreyfus’s view is one in which a kind of ethical comportment is more important than sophisti-cated reasoning: moral maturity ‘is primarily about an ethi-cal comportment to situations in the world rather than about coming to have more sophisticated cognitions and judgments about principles and rule-following’ (Reynolds 2006, 545). Ethics seems to require the development of a practical wis-dom which can respond intuitively and appropriately to spe-cific situations. This sounds like virtue ethics. Dreyfus might" 5235 5836 W2785973954.pdf 11 0 title 0.65887743 Correction: Hot o ffthe press 0 28 W2522002087.pdf 0 1 separator 0.8421725 ¶ 28 30 W2522002087.pdf 0 2 paratext 0.6626716 Robert A. Hill and Andrew Sutherland 30 67 W2522002087.pdf 0 3 separator 0.98883784 ¶ 67 69 W2522002087.pdf 0 4 text 0.7871379 Correction for ‘Hot o ffthe press ’by Robert A. Hill et al. ,Nat. Prod. Rep. , 2016, DOI: 10.1039/c6np90039a. 69 178 W2522002087.pdf 0 5 separator 0.8801241 ¶ 178 180 W2522002087.pdf 0 6 text 0.9578982 There was an error in the structure of compound 18on page 2. The correct structure is as follows: 180 278 W2522002087.pdf 0 7 separator 0.9231744 ¶ 278 280 W2522002087.pdf 0 8 text 0.94239706 The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers. 280 396 W2522002087.pdf 0 9 separator 0.97189677 ¶ 396 398 W2522002087.pdf 0 10 contact 0.9918689 School of Chemistry, Glasgow University, Glasgow, G12 8QQ, UK. E-mail: Bob.Hill@glasgow.ac.uk 398 492 W2522002087.pdf 0 11 paratext 0.9731613 "Cite this: Nat. Prod. Rep. ,2 0 1 6 , 33, 1239 DOI: 10.1039/c6np90040b www.rsc.org/npr" 492 584 W2522002087.pdf 0 12 separator 0.6749031 ¶ 584 586 W2522002087.pdf 0 13 paratext 0.96711195 This journal is © The Royal Society of Chemistry 2016 Nat. Prod. Rep. ,2 0 1 6 , 33, 1239 | 1239Natural Product 586 698 W2522002087.pdf 0 14 separator 0.62345755 ¶ 698 700 W2522002087.pdf 0 15 title 0.6680482 Reports 700 708 W2522002087.pdf 0 16 separator 0.6169741 ¶ 708 710 W2522002087.pdf 0 17 title 0.7777682 CORRECTION 710 721 W2522002087.pdf 0 18 separator 0.85710573 ¶ 721 723 W2522002087.pdf 0 19 paratext 0.9339281 "Open Access Article. Published on 21 September 2016. Downloaded on 5/18/2024 5:52:01 AM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence." 723 903 W2522002087.pdf 0 20 separator 0.8963628 ¶ 903 905 W2522002087.pdf 0 21 paratext 0.38417804 View 905 910 W2522002087.pdf 0 22 text 0.31299052 Article 910 918 W2522002087.pdf 0 23 paratext 0.36069417 Online 918 925 W2522002087.pdf 0 24 separator 0.50952315 ¶ 925 927 W2522002087.pdf 0 25 paratext 0.41161385 "View Journal | View Issue" 927 956 W2522002087.pdf 0 0 math 0.95764893 "T T rr,1 2,2 iii ijji i jj ,22∑∑ ∑[̂·∇] = − [∇ ]·∇ = − ∇ = ̂ (17)" 0 77 W3080358204.pdf 3 1 separator 0.46987855 ¶ 77 79 W3080358204.pdf 3 2 text 0.85295147 "where [ ∇j2,ri] means that the Laplacian is applied to each coordinate component operator separately which then makesup a new vector. Note that all terms are treated as operators, so∇f(r)=(∇f(r)) + f(r)∇by the chain rule." 79 303 W3080358204.pdf 3 3 separator 0.9760753 ¶ 303 305 W3080358204.pdf 3 4 math 0.8600164 "W Wrr r r rr r r r r rrr rrrrr rr rr,1 2, 1 2(( ) ( ) ) 1 2 1 21iii ij kij k i j" 305 416 W3080358204.pdf 3 5 table 0.49819207 kj 416 418 W3080358204.pdf 3 6 math 0.5227774 418 419 W3080358204.pdf 3 7 table 0.5073467 i 419 420 W3080358204.pdf 3 8 math 0.47957033 jk 420 423 W3080358204.pdf 3 9 table 0.49356136 k k jk ¶ 423 432 W3080358204.pdf 3 10 math 0.47968036 432 433 W3080358204.pdf 3 11 table 0.5439709 jkjjk ¶ 433 440 W3080358204.pdf 3 12 math 0.5283007 440 441 W3080358204.pdf 3 13 table 0.52035505 jkkjk ¶ 441 448 W3080358204.pdf 3 14 math 0.956035 "jk jk jk,1 11 33∑∑ ∑ ∑ ∑[̂·∇] = ·[| − | ∇] =· − ∇ | − | + · − ∇ | − | =·− |−|−·− |−| =|−|=̂≠− ≠−− ≠ ≠i kjjjjjjy {zzzzzz (18) Vv vrr r r r,( ) , ( ( ) ) iii ijij i iiii ,∑∑ ∑[̂·∇] = ·[ ∇] = − · ∇ (19) Hp pHrr r r,( ) , ()iii ijij i jjc ,, ,c∑∑ ∑λ λω ω[̂·∇] = − ·[ · ∇] ̂ =· ̂=− ̂ααα α ααα α (20) HH rr r r,1 2() () , 2 iii ijkij k i d ,, ,d ∑∑ λλ [̂·∇] = ·[ · · ∇] = − ̂ ααα (21)" 448 915 W3080358204.pdf 3 15 separator 0.9201782 ¶ 915 917 W3080358204.pdf 3 16 text 0.9931854 "Taking all these results together the new electronic virial theorem with mode-coupling is found" 917 1015 W3080358204.pdf 3 17 separator 0.84832525 ¶ 1015 1017 W3080358204.pdf 3 18 math 0.9669857 TWH H Nv rr 2 2( ( ) )cd ⟨̂⟩+⟨ ̂⟩−⟨ ̂⟩− ⟨ ̂⟩= ⟨·∇ ⟩ (22) 1017 1074 W3080358204.pdf 3 19 separator 0.9407966 ¶ 1074 1076 W3080358204.pdf 3 20 text 0.99834996 "We see that all terms from the original Hamiltonian are involved, except the field-energy of the cavity modes Ĥband the energy from the external force on the modes Ĥext. Thus, this virial relation connects all the constituents of the systemwhich could be expressed of purely electronic degrees offreedom with the dipole-coupling energy which is the onlyterm of the mixed electron-boson nature." 1076 1477 W3080358204.pdf 3 21 separator 0.9611827 ¶ 1477 1479 W3080358204.pdf 3 22 text 0.9982489 "Some comments are in order here. First, by setting the fundamental light-matter coupling to λ α= 0, we recover the virial for electronic structure ( 16) as requested. An alternative route to derive the basic virial theorem is from the force-balance equation for stationary states.14If the force totals to f(r) = 0 at every point r, as will be the case for eigenstates, then taking the space integral ∫f(r)·rdrresults in ( 22). Let us also point out that the implications of the force balance equationfor functional construction in the context of time-dependentQEDFT 14,16,19has been discussed in Tokatly.65" 1479 2102 W3080358204.pdf 3 23 separator 0.9963318 ¶ 2102 2104 W3080358204.pdf 3 24 title 0.993344 5. FIELD-MODE VIRIAL THEOREM 2104 2133 W3080358204.pdf 3 25 separator 0.9958978 ¶ 2133 2135 W3080358204.pdf 3 26 text 0.9983453 "Next, we derive an analogous equation of motion on the side of the modes, which means that we combine the modeoperators into an mode virial operator ∑ αq̂αp̂α. In the equation of motion ∑α⟨[Ĥ,q̂αp̂α]⟩, only three terms contribute and we use the commutators ( 1), (8), (9), and ( 10) for evaluation." 2135 2443 W3080358204.pdf 3 27 math 0.96580106 "Hq p p q p q q p ip q,1 2(, , ) ()b ,22 2 22 2∑∑ ∑ω ω[̂̂̂]= [ ̂̂]̂+̂[̂̂] =− ̂+̂ααα αβα β αα αβ α ααα α(23) Hq p pqp i H r ,( ) , ii c ,,c ∑∑ λω [̂̂̂]=− · [ ̂̂]̂=− ̂ ααα αβββ β αα (24) Hq pf pq p i H ,,ext ,ext ∑∑ω[̂ ̂̂]= [ ̂̂]̂=− ̂ ααα αββ ββ αα (25)" 2443 2739 W3080358204.pdf 3 28 separator 0.9815272 ¶ 2739 2741 W3080358204.pdf 3 29 text 0.99934804 "The relation ( 23) yields, as one would expect, just the virial theorem for the harmonic oscillator. Together, with the otherrelations, that just give back the coupling and external-forceenergies, we arrive at the field-mode virial theorem" 2741 2982 W3080358204.pdf 3 30 separator 0.9296734 ¶ 2982 2984 W3080358204.pdf 3 31 math 0.9681707 "pq H H22 2 ce x t ∑ω⟨̂−̂⟩−⟨ ̂⟩=⟨ ̂⟩ αα α α(26)" 2984 3035 W3080358204.pdf 3 32 separator 0.98550475 ¶ 3035 3037 W3080358204.pdf 3 33 text 0.9992809 "We see that the field-mode virial theorem has a similar structure than the electronic virial theorem from ( 22), with an external in fluence on the right and a connection between purely bosonic parts of the system with the dipole-couplingenergy on the left. The field-mode virial theorem ( 26) is also a consequence of the equation of motion that involves thesecond time-derivative of Ĥ b." 3037 3435 W3080358204.pdf 3 34 separator 0.92385936 ¶ 3435 3437 W3080358204.pdf 3 35 text 0.9984768 "Another useful relation arises if we choose the equation of motion for the much simpler operator p̂α. Here, only Ĥb contributes and, using ( 10), [Ĥ,p̂α]= iq̂α. Computing the second time derivative, we have to look at the doublecommutator [ Ĥ,[Ĥ,p̂ α]], so" 3437 3706 W3080358204.pdf 3 36 separator 0.962074 ¶ 3706 3708 W3080358204.pdf 3 37 math 0.96375555 "Hi q p q p,1 2,b22 2∑ωω [̂̂]= [ ̂̂]= ̂α βα β α αα (27) Hi q i pq rr ,( ) , ( ) ii jj c ,∑∑ λλωω [̂̂]=− · [ ̂̂]=− ·α βββ β α αα (28) Hi q if pqf ,,ext ∑ωω[̂ ̂]= [ ̂̂]=α ββ ββ αα α (29)" 3708 3922 W3080358204.pdf 3 38 separator 0.65636706 ¶ 3922 3924 W3080358204.pdf 3 39 text 0.99312866 "Summing those terms and taking the expectation value that must be zero, we have" 3924 4006 W3080358204.pdf 3 40 separator 0.64754224 ¶ 4006 4008 W3080358204.pdf 3 41 math 0.9581437 "pf r jj2∑ λ ωωω⟨̂⟩− ⟨ ⟩ · =−α α ααα α (30)" 4008 4057 W3080358204.pdf 3 42 separator 0.92174935 ¶ 4057 4059 W3080358204.pdf 3 43 text 0.99893093 "This relation corresponds to the mode-resolved Maxwell equation for the displacement field, see for example Flick et al.17In contrast to the connection between the electronic force-balance equation and the electronic virial theorem in theprevious section, it does not give rise to a virial theorem byitself, but it will be employed in the derivation of the next virial relation." 4059 4445 W3080358204.pdf 3 44 separator 0.99619067 ¶ 4445 4447 W3080358204.pdf 3 45 title 0.9896958 "6. MODE-COUPLED VIRIAL ESTIMATE AND CONNECTION TO MASS RENORMALIZATION" 4447 4520 W3080358204.pdf 3 46 separator 0.99385023 ¶ 4520 4522 W3080358204.pdf 3 47 text 0.9715543 "In the search for another virial relation that will relate the electronic and field parts of the Hamiltonian, we consider the equation of motion of an operator that includes both electroncoordinates and mode coordinates. A promising candidate, aswe will see, is the mixed virial operator ∑ i(λα·ri)q̂α. We deriveJournal of Chemical Theory and Computation pubs.acs.org/JCTC" 4522 4900 W3080358204.pdf 3 48 paratext 0.9570083 "Article https://dx.doi.org/10.1021/acs.jctc.0c00618" 4900 4954 W3080358204.pdf 3 49 separator 0.7075031 ¶ 4954 4956 W3080358204.pdf 3 50 paratext 0.9877865 J. Chem. Theory Comput. 2020, 16, 6236 −62436239 4956 5005 W3080358204.pdf 3 51 separator 0.99474955 ¶ 5005 5007 W3080358204.pdf 3 0 paratext 0.7755441 222 Irish Studies in International Affairs 0 45 W4241365136.pdf 2 1 text 0.99878496 "a special franchise will inevitably be compared to the conduct of the Scottish Independence referendum in 2014 (and any future Scottish Independence ref - erendum). It is also, however, a more complex proposition because such a referendum will need to be considered in terms of its direct comparability to a concurrent referendum on (re)unification held in Ireland." 47 424 W4241365136.pdf 2 2 separator 0.9893266 ¶ 424 426 W4241365136.pdf 2 3 text 0.9995343 "As McCrudden, Doyle and Kenny identify, these impetuses pull in different directions, and as a result, as they state, ‘the most sensible approach to take to the franchise issue is likely to be to adopt a Venice-informed presumption against departure from the existing franchise’. As constitutional lawyers, it is always reassuring to clothe arguments as to the appropriate franchise for a ref - erendum in the Venice Commission’s Code of Good Practice on Referendums, but its soft-law terms are unlikely to stand up against the expectations around special franchise arrangements in the likely context of a (re)unification ref - erendum. Just because discussion of a possible referendum is currently taking place without the involvement of Northern Ireland’s unionist parties does not mean that the franchise issue will not become increasingly contested." 426 1308 W4241365136.pdf 2 4 separator 0.9891211 ¶ 1308 1310 W4241365136.pdf 2 5 text 0.99938446 "The conclusion of the Anglo-Irish Agreement and Brexit’s Ireland/Northern Ireland Protocol illustrate that unionist parties can rapidly transition from refusing to engage with ideas that do not align with their account of Northern Ireland’s constitutional status where there is perceived to be no benefit in engagement, to hyper-engaged obstructionism. Political unionism’s current studied lack of engagement in a (re)unification referendum is not accidental." 1310 1785 W4241365136.pdf 2 6 separator 0.96126354 ¶ 1786 1788 W4241365136.pdf 2 7 text 0.9993909 "The main unionist parties want to do nothing to lend credibility to the possi - bility of such a vote. Disengagement should not be confused with disinterest." 1788 1948 W4241365136.pdf 2 8 separator 0.9848832 ¶ 1948 1950 W4241365136.pdf 2 9 text 0.99937946 "Successive Conservative secretaries of state for Northern Ireland have made it abundantly clear that they would require overwhelming evidence of majority support in Northern Ireland before they would regard the UK gov - ernment as being under a duty to conduct such a referendum. Even if opinion polls or election results suggested a shift in public opinion, the UK government has given no indication of what evidence it would regard as definitive. The Northern Ireland parties, however, also know that the secretary of state has the power to initiate the process separate from the legal duty to do so, and that the UK government’s calculus around a vote could shift (especially as influen - tial pro-Brexit commentators increasingly form conjecture about the benefits of Northern Ireland ceasing to be part of the UK for the purity of Brexit)." 1950 2823 W4241365136.pdf 2 10 separator 0.9653585 ¶ 2823 2825 W4241365136.pdf 2 11 text 0.9994026 "In such an eventuality, a protracted contest is likely to emerge over the legitimacy of the arrangements for the referendum. The franchise for a (re) unification referendum is going to be the subject of intense horse trading" 2825 3055 W4241365136.pdf 2 0 paratext 0.98394907 P . R. Duffy et al. 0 19 W4291017823.pdf 28 1 separator 0.9887639 ¶ 19 21 W4291017823.pdf 28 2 bibliography 0.9648989 Mesolithic chipped stone artefact types (Eichmann et al., 2010 ; Marton et al., 2021 ). 21 109 W4291017823.pdf 28 3 separator 0.9930128 ¶ 110 112 W4291017823.pdf 28 4 text 0.99920183 "Szekszárd-Palánk has been published for sixty years (Vértes, 1962 ), and has sev - eral sites within a ten-km radius—the area is potentially rich in further Mesolithic finds according to the predictive map. Further work in the Szekszárd area could be of value from the perspective of studying hunter-gatherer-first farmer interactions." 112 456 W4291017823.pdf 28 5 separator 0.95368963 ¶ 457 459 W4291017823.pdf 28 6 text 0.9986409 "They are areas of rapidly changing ecozones as one moves across the landscape, going from flat, swampy areas near to major rivers, to slightly higher areas prioritiz - ing access to medium sized rivers closer to raw material sources. In Online Resource 6, we highlight additional areas of potential interest, including the Jászság and Sered regions, known areas of Mesolithic activity, but also the Kaposhomok and Hajdu - kovo regions, which each have Mesolithic sites known from surface collection, but seem to be good regional candidates for systematic survey." 459 1038 W4291017823.pdf 28 7 separator 0.9958588 ¶ 1038 1040 W4291017823.pdf 28 8 title 0.99012786 Discussion 1040 1051 W4291017823.pdf 28 9 separator 0.99685764 ¶ 1051 1053 W4291017823.pdf 28 10 text 0.9849711 "The landscape associations of Mesolithic and Early Neolithic sites paint two differ - ent pictures of the kinds of lands sought by ancient people between 8 and 6 ka BC. These result from different routes of incursion and different uses of the landscape. " 1053 1314 W4291017823.pdf 28 11 separator 0.52842635 ¶ 1314 1315 W4291017823.pdf 28 12 text 0.9903628 "Mesolithic sites are the harder of the two site types to find, so we plot locations of Mesolithic and Early Neolithic sites over the Mesolithic predictive map in Fig. 12 to illustrate these differences. Although there are broad similarities between the two—for example, in being close to marshland and settling in flat areas—it is clear that Early Neolithic farmers settled in areas least preferred by Mesolithic foragers, though dates obtained on human remains at the Early Neolithic site of Maroslele- Pana and others indicate occasional presence of Mesolithic-age material on Early Neolithic sites in the region (Borić, 2005 ; Whittle et al., 2002 , 2005 ; Živaljević et al., 2021 )." 1315 2028 W4291017823.pdf 28 13 separator 0.9877473 ¶ 2028 2030 W4291017823.pdf 28 14 text 0.99928266 "Searching for evidence of temporal overlap between the last foragers and first farmers, and identifying interactions between them, would nonetheless take us to parts of the Carpathian Basin where there is clearer spatial overlap in settlement patterns, even though so far it seems as though almost exclusively Early Meso - lithic dates have been obtained in the Carpathian Basin with little evidence of tem - poral overlap with the first Neolithic farmer occupations. At least at lower eleva - tions, this could result from more severe erosional events during the later part of the Mesolithic. Such a scenario has been suggested based on the results of a systematic archaeological survey combined with geomorphological observations and radiocar - bon dating of soil organic matter samples on exposed riverbank sections in the area downstream from the Danube Gorges along the Danube River between Radujevac and Prahovo. The results of these investigations suggested that while lower parts of the soil deposits dating to the period between 12,710 ± 70 cal BC and 9670 ± 70 cal BC at 68 percent confidence, i.e., covering the duration of the Early Mesolithic, were preserved, the bulk of the deposits dated to the Late Mesolithic/Early Neolithic periods was lacking from these riverbank sections (Radovanovi ć et al., 2014 )." 2030 3396 W4291017823.pdf 28 15 separator 0.9611149 ¶ 3396 3398 W4291017823.pdf 28 16 text 0.99884903 "There has been some discussion suggesting that Mesolithic populations were so rare in certain areas of the Balkans in the late Pleistocene and early Holocene," 3398 3560 W4291017823.pdf 28 17 separator 0.9737395 ¶ 3561 3563 W4291017823.pdf 28 18 paratext 0.9846453 1 3664 3563 3570 W4291017823.pdf 28 0 title 0.9231328 MiR-200c Regulation of Noxa and Apoptosis 0 41 W2063675844.pdf 7 1 separator 0.9864171 ¶ 41 43 W2063675844.pdf 7 2 paratext 0.97343165 PLoS ONE | www.plosone.org 8 May 2012 | Volume 7 | Issue 5 | e36490 43 111 W2063675844.pdf 7 0 caption 0.9800345 "Fig. 2. a. Which areas of radiography (diagnostic) do you think there is the greatest scope for the development of AI systems in the future (mean score)? b. Which areas of radiography (therapeutic) do you think there is the greatest scope for the development of AI systems in the future (mean score)?" 0 309 W4282937833.pdf 7 1 separator 0.9928806 ¶ 310 312 W4282937833.pdf 7 2 text 0.99770594 "AI has scope for development in all modalities ( n = 1). There were no free text answers to this question in the TR responses." 312 446 W4282937833.pdf 7 3 separator 0.9960704 ¶ 448 450 W4282937833.pdf 7 4 title 0.98918766 Expectations of the impact of AI on the future of radiography 450 514 W4282937833.pdf 7 5 separator 0.9937272 ¶ 516 518 W4282937833.pdf 7 6 text 0.99916834 "Likert scale questions were used to gain insight into the re- spondents’ perceptions on how AI might impact radiography and professional practice in the future. The majority in both professions indicated they agreed that AI would change daily clinical practice, with an aggregate agreement (strongly agree, agree, somewhat agree) of 79.6% and 88.9% for DR and TR respectively ( Fig. 3 ). A less definitive perception was noted in re- sponse to the question of AI reducing radiographers’ workload with an aggregate agreement of 43.5% and 54.0% and an ag- gregate disagreement of 27.3% and 27.0% DR and TR respec- tively ( Fig. 4 ). An even smaller degree of difference in agreement and disagreement aggregates was noted in response to the state- ment ‘AI will make my practice more patient centered’, with agreement aggregates of 36.6% and 45.9% and disagreement aggregates of 22.4% and 27.0% for DR and TR respectively ( Fig. 5 ). The greatest proportion of responses to this statement were recorded in the ‘neither agree nor disagree’ choice." 518 1670 W4282937833.pdf 7 7 separator 0.9817019 ¶ 1672 1674 W4282937833.pdf 7 8 text 0.99931 "Most respondents agreed that AI would provide more con- sistent patient safety standards in radiography (aggregate agree- ment 68.3%, 73.0%, aggregate disagreement 7.1% and 9.6% DR and TR respectively) ( Fig. 6 ). Similar results were also noted in response to the statement ‘AI will allow for more con- sistent patient care pathways’, with an aggregate agreement of 62.5% and 58.6% and an aggregate disagreement of 6.0% and 9.6% DR and TR respectively ( Fig. 7 )." 1674 2183 W4282937833.pdf 7 9 separator 0.9689429 ¶ 2184 2186 W4282937833.pdf 7 10 text 0.99860686 "Specific statements were presented to each individual pro- fession (DR and TR) regarding the impact of AI on profession- specific areas of practice ( Figs. 8 and 9 ). The DR respondents were asked to what extent they agreed that ‘AI will improve and" 2186 2457 W4282937833.pdf 7 11 separator 0.9798982 ¶ 2458 2460 W4282937833.pdf 7 12 paratext 0.75784963 C. Rainey, 2460 2471 W4282937833.pdf 7 13 bibliography 0.59714675 T. 2471 2474 W4282937833.pdf 7 14 paratext 0.50534856 O’ 2474 2477 W4282937833.pdf 7 15 bibliography 0.4845697 Reg 2477 2480 W4282937833.pdf 7 16 paratext 0.50168186 an 2480 2482 W4282937833.pdf 7 17 bibliography 0.613735 , J. Matthew et al. / Journal of Medical Imaging and Radi 2482 2541 W4282937833.pdf 7 18 paratext 0.74942565 ation Sciences 53 (2022) 347–361 353 2541 2579 W4282937833.pdf 7 0 paratext 0.77105874 Ocimum gratissimum essential oil for matrinxa anesthesia 3 0 60 W2285505626.pdf 2 1 separator 0.8714162 ¶ 61 63 W2285505626.pdf 2 2 paratext 0.9560313 Acta Scientiarum. Animal Sciences Maringá, v. 38, n. 1, p. 1-7, Jan.-Mar., 2016 63 144 W2285505626.pdf 2 3 title 0.4100114 in 144 147 W2285505626.pdf 2 4 text 0.942199 "Manaus. Fish were fed once a day for one month, with commercial pellet ration containing 28% crude protein. Feeding was stopped one day before the experiment." 147 312 W2285505626.pdf 2 5 separator 0.83343244 ¶ 314 316 W2285505626.pdf 2 6 text 0.99933034 "The cages were randomly arranged for the 4 treatments with 3 repetitions each. In the control treatment (C), the sampled fish were not anesthetized or handled in any way. Fish from the handling group (H) were transferred from the cage to a 20-L bucket for 10 min., to simulate handling and crowding, and then returned to the cage. The groups subjected to both handling and anesthesia (HA) and handling and deep anesthesia (HDA) were subjected to similar experimental procedures, except for the the addition of 20 and 60 mg L -1 EO to the buckets, respectively. Tissues and blood samples were taken from 3 fish in each cage after they were moved from the buckets to the cages (T0). Three other fish from each cage were sampled 24h later (T24). The remaining fish were fed and observed for another month. Then they were counted and discarded." 316 1166 W2285505626.pdf 2 7 separator 0.9738682 ¶ 1168 1170 W2285505626.pdf 2 8 text 0.9989954 "Fish sampled from each treatment were killed by a sharp blow to the head and their blood harvested from the caudal vein using 3 mL syringes (rinsed with 10 % EDTA). Fragments of liver and white muscle were collected for glycogen determination (Bidinotto, Moraes, & Souza, 1997)." 1170 1455 W2285505626.pdf 2 9 separator 0.96111345 ¶ 1457 1459 W2285505626.pdf 2 10 text 0.99958575 "Blood samples were used for hematocrit (Goldenfarb, Bowyer, Hall & Brosious, 1971) and total hemoglobin determination (Drabkin, 1948) and red cell count (Lima, Soares, Greco, Galizzi, & Cançado, 1969). In addition, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were calculated (Lima et al., 1969)." 1459 1832 W2285505626.pdf 2 11 separator 0.9384252 ¶ 1834 1836 W2285505626.pdf 2 12 text 0.9990161 "After centrifugation of blood aliquots (14400 G x 3 min.), plasma was used to determine glucose (Trinder, 1969), total ammonia (Gentzkow & Masen, 1942), lactate (Harrower & Brown, 1972), chloride American Public Health Association (APHA, 1980), total protein (Lowry, Rosebrought, & Farr, 1951) Na and K levels by flame photometry (Digimed, DM-61 model)." 1836 2193 W2285505626.pdf 2 13 separator 0.9971169 ¶ 2194 2196 W2285505626.pdf 2 14 title 0.9895467 Data analyses 2196 2210 W2285505626.pdf 2 15 separator 0.9953103 ¶ 2212 2214 W2285505626.pdf 2 16 text 0.999493 "Data on anesthetic induction were evaluated b y p o l y n o m i a l r e g r e s s i o n ( p < 0 . 0 5 ) . D a t a o n both anesthetic induction and physiological parameters were submitted to one-way ANOVA followed by tukey’s test for multiple comparisons (p < 0.05)." 2214 2498 W2285505626.pdf 2 17 title 0.9786079 Results and discussion 2499 2522 W2285505626.pdf 2 18 separator 0.99586034 ¶ 2523 2525 W2285505626.pdf 2 19 text 0.9997016 "The major components were eugenol, 1.8 cineole and beta-selinene (Table 1). Eugenol content was lower than observed by Silva et al. (2012). This may change according to plant specific genetic characteristics and local conditions. Usually when the major component decrease minors increase. In general, there is no uniform essential oil composition. This may change when oil is extract from different parts of the same plant, farming practices, and extraction method. Difference in the compositon is known as the oil components are plant metabolism products so variable according plants life cicle. Some components transformations to anothers may take place, and even after oil extraction. Reactions among the different oil components may occur as interactions among oil and environmental factors (light, enzymes and the container) are dynamics (Luz, Ehlert, & Innecco, 2009)." 2525 3403 W2285505626.pdf 2 20 separator 0.9975241 ¶ 3405 3407 W2285505626.pdf 2 21 title 0.86298627 Table 1. Main components of O. gratissimum essential oil. 3407 3465 W2285505626.pdf 2 22 separator 0.8502164 ¶ 3466 3468 W2285505626.pdf 2 23 table 0.9952771 "Retention Index1. RI1 Component % 938 alpha-pinene 1.0 975 sabinene 0.7 979 beta-pinene 2.8 991 myrcene 0.7 1032 1,8-cineole 28.2 1038 cis-ocimene 3.7 1049 trans-ocimene 0.0 1097 linalol 1.3 1166 delta-terpineol 0.4 1176 4-terpineol 0.4 1188 alpha-terpineol 1.1 1357 eugenol 43.3 1381 beta-bourbonene 0.9 1389 beta-elemene 0.8 1415 beta-caryophyllene 3.7 1450 alpha-humulene 0.6 1477 gamma-muurolene 0.9 1482 beta-selinene 5.5 1490 alpha-selinene 1.7 1513 7- epi-alpha-selinene 0.4 Total 98.1" 3468 3990 W2285505626.pdf 2 24 separator 0.9863687 ¶ ¶ 3991 3997 W2285505626.pdf 2 25 text 0.99921906 "The movement of fish was always intense when they entered the anesthetic bath. After a few seconds, they were less agit ated and started losing equilibrium. Total loss of equilibrium and inability to regain the upright position was achieved in less than 10 min. Anesthetic induction time was longer in the treatment using the lowest EO concentration of 20 mg L-1 than in that using 30 mg L-1, and data from both exhibited higher standard deviations than the other treatments (from 40 to 80 mg L-1). Treatments testing EO concentrations from 40 to 80 mg L-1 showed similar induction time for anesthesia (Figure 1)." 3997 4648 W2285505626.pdf 2 0 paratext 0.98668635 Page 6 of 7 Behera et al. BMC Surg (2021) 21:28 0 57 W3120872941.pdf 5 1 separator 0.9818033 ¶ 58 60 W3120872941.pdf 5 2 text 0.96083516 "uncultured bacteria. This is a very challenging area of research that needs clear understanding of the metabolic pathway of these bacteria." 60 206 W3120872941.pdf 5 3 separator 0.99451804 ¶ 206 208 W3120872941.pdf 5 4 title 0.9862342 Conclusions 208 220 W3120872941.pdf 5 5 separator 0.99372417 ¶ 220 222 W3120872941.pdf 5 6 text 0.99923074 "Despite development in surgical and sterilization tech - niques and use of prophylactic antimicrobials, SSIs con - tinue to pose clinical challenge. SSI samples of patients with no growth in culture after 48 h of incubation fur - ther complicates the situation. Certain experimental measures can be taken to improve the diagnosis of such culture negative samples. First culture plates should be allowed to incubate for an additional 3–4 days, which will allow the growth of fastidious bacteria if present." 222 750 W3120872941.pdf 5 7 separator 0.7120495 ¶ 751 753 W3120872941.pdf 5 8 text 0.998859 "Second as anaerobic culture system is rarely available in the microbiology laboratory in Indian set up, it should be made available so that anaerobic bacteria can be identi - fied in culture. Third as several unculturable bacteria and VBNC bacteria are responsible of culture negative SSI, molecular diagnosis by 16Sbroad range PCR assay can be employed for identifying such organisms in sample to help the clinicians in prescribing appropriate antibiotic to the patient. The study can further be extended to detect the antibiotic sensitivity /resistance pattern and study epidemiology of VBNC, anaerobes and unculturable bac - teria using 16S broad range PCR assay." 753 1451 W3120872941.pdf 5 9 separator 0.99676305 ¶ 1451 1453 W3120872941.pdf 5 10 title 0.9750767 Abbreviations 1453 1467 W3120872941.pdf 5 11 separator 0.98860765 ¶ 1467 1469 W3120872941.pdf 5 12 text 0.82970613 SSI: Surgical site Infections; PCR: Polymerase chain reaction. 1469 1532 W3120872941.pdf 5 13 separator 0.99604434 ¶ 1532 1534 W3120872941.pdf 5 14 title 0.9751494 Acknowledgements 1534 1551 W3120872941.pdf 5 15 separator 0.99038255 ¶ 1551 1553 W3120872941.pdf 5 16 text 0.99154156 "Author thank Science and Engineering Research Board(SERB) of India for funding this study. Author also thanks all the clinical faculty members and resident doctors of SCB medical college for sending the clinical specimens for molecular investigations." 1553 1814 W3120872941.pdf 5 17 separator 0.996343 ¶ 1814 1816 W3120872941.pdf 5 18 title 0.98575866 Authors’ contributions 1816 1839 W3120872941.pdf 5 19 separator 0.9906356 ¶ 1839 1841 W3120872941.pdf 5 20 text 0.99655247 "All authors contributed significantly to this study. HB: participated substan- tially in conception, execution of the study and drafting the manuscript; NC: participated substantially in execution of the study, acquisition of data and collection of clinical samples; MSB: participated substantially in design of the study and interpretation of data, HKK: participated substantially in analysis and interpretation of data, SP: participated substantively in execution of the study and revising the manuscript SD: participated substantially in execution of the study and collection of clinical samples; MRR: participated substantially in execution of the study, interpretation of data and revising the manuscript. All authors have read and approved the final manuscript." 1841 2635 W3120872941.pdf 5 21 separator 0.996244 ¶ 2635 2637 W3120872941.pdf 5 22 title 0.9723519 Funding 2637 2645 W3120872941.pdf 5 23 separator 0.9902475 ¶ 2645 2647 W3120872941.pdf 5 24 text 0.99345523 There is no funding from the institute for publication. 2647 2703 W3120872941.pdf 5 25 separator 0.99562335 ¶ 2703 2705 W3120872941.pdf 5 26 title 0.9852547 Availability of data and materials 2705 2740 W3120872941.pdf 5 27 separator 0.9879432 ¶ 2740 2742 W3120872941.pdf 5 28 text 0.99866 "All the data related to the manuscript is available in NCBI. All the nucleotide sequences were submitted to the NCBI data bank and obtained the Accession numbers. So, these are available from NCBI and given in Table 1." 2742 2967 W3120872941.pdf 5 29 separator 0.996214 ¶ 2967 2969 W3120872941.pdf 5 30 title 0.98799384 Ethics approval and consent to participate 2969 3012 W3120872941.pdf 5 31 separator 0.9843199 ¶ 3012 3014 W3120872941.pdf 5 32 text 0.9985244 "This study was approved by the Research and Ethics Committee of Regional Medical Research Centre (RMRC), Bhubaneswar, Odisha (Ref No. ECR/911/Inst/ OR/2017). Research methodology followed was adhered to the tenets of the Declaration of Helsinki. All the participants had given their consent in written before sample collection in their vernacular language." 3014 3379 W3120872941.pdf 5 33 separator 0.99468136 ¶ 3379 3381 W3120872941.pdf 5 34 title 0.92878157 Consent for publication 3381 3405 W3120872941.pdf 5 35 separator 0.929665 ¶ 3405 3407 W3120872941.pdf 5 36 text 0.8395694 Not applicable. 3407 3423 W3120872941.pdf 5 37 separator 0.994541 ¶ 3423 3425 W3120872941.pdf 5 38 title 0.97487366 Competing interests 3425 3445 W3120872941.pdf 5 39 separator 0.9691354 ¶ 3445 3447 W3120872941.pdf 5 40 text 0.9762558 The authors declare that, there are no conflicts of interest related to this work. 3447 3530 W3120872941.pdf 5 41 separator 0.9956273 ¶ 3530 3532 W3120872941.pdf 5 42 contact 0.5546584 Author 3532 3539 W3120872941.pdf 5 43 title 0.5861096 details 3539 3547 W3120872941.pdf 5 44 separator 0.9701475 ¶ 3547 3549 W3120872941.pdf 5 45 contact 0.98483187 "1 ICMR-Regional Medical Research Centre, Bhubaneswar 751023, Odisha, India. 2 Department of Molecular Epidemiology, ICMR-Regional Medical Research Centre, Bhubaneswar 751023, India. 3 Department of Microbiology, SCB Medical College and Hospital, Cuttack 753003, India. 4 Department of Parasite Immunology, ICMR-Regional Medical Research Centre, Bhubaneswar 751023, India. 5 Department of Public Health, ICMR-Regional Medical Research Centre, Bhubaneswar, India." 3549 4029 W3120872941.pdf 5 46 separator 0.8678818 ¶ 4030 4032 W3120872941.pdf 5 47 paratext 0.9832496 Received: 8 June 2020 Accepted: 15 December 2020 4032 4083 W3120872941.pdf 5 48 separator 0.9866268 ¶ 4083 4085 W3120872941.pdf 5 49 title 0.78245723 References 4085 4096 W3120872941.pdf 5 50 separator 0.98544383 ¶ 4096 4098 W3120872941.pdf 5 51 bibliography 0.9977066 "1. 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Current perspectives on viable but non-culturable state in foodborne pathogens. Front Microbiol. 2017;4(8):580." 6447 6609 W3120872941.pdf 5 78 separator 0.96284777 ¶ 6609 6611 W3120872941.pdf 5 79 bibliography 0.99796474 "15. Edmiston C Jr, Krepel C, Seabrook G, Jochimsen W. Anaerobic infections in the surgical patient: microbial etiology and therapy clinical infectious diseases. Clin Infect Dis. 2002a;35:S112–8." 6612 6813 W3120872941.pdf 5 80 separator 0.95325303 ¶ 6813 6815 W3120872941.pdf 5 81 bibliography 0.99785846 "16. Rasnake M, Dooley D. Culture-negative surgical site infections. Surg Infect. 2007;7:555–65." 6816 6915 W3120872941.pdf 5 82 separator 0.9478108 ¶ 6915 6917 W3120872941.pdf 5 83 bibliography 0.99785256 17. Stewart E. Growing unculturable bacteria. J Bacteriol. 2012;194:4151–60. 6918 6995 W3120872941.pdf 5 0 paratext 0.9872001 January 19, 2016 2:58 ws-procs961x669 WSPC Proceedings - 9.61in x 6.69in ws-procs961x669 page 1 0 95 W2264287916.pdf 0 1 separator 0.8863947 ¶ 95 97 W2264287916.pdf 0 2 paratext 0.8690513 1 97 99 W2264287916.pdf 0 3 separator 0.98928374 ¶ 99 101 W2264287916.pdf 0 4 title 0.9913017 Modi ed gravity and binary pulsars: the Lorentz violating case 101 164 W2264287916.pdf 0 5 separator 0.98482877 ¶ 164 166 W2264287916.pdf 0 6 contact 0.98418236 "D. Blas Theoretical Physics Department, CERN, Geneva, Switzerland. E-mail: diego.blas@cern.chCERN-TH-2016-014" 166 282 W2264287916.pdf 0 7 separator 0.99238646 ¶ 282 284 W2264287916.pdf 0 8 text 0.9991797 "The dynamics of binary pulsars can be used to test dierent aspects of gravitation. This is particularly important to constrain alternatives to general relativity in regimes which are not probed by other methods. In this short contribution, I will describe the case of theories of gravity without Lorentz invariance. The latter are important in the context of quantum gravity and modify the laws of gravity at basically all scales." 284 724 W2264287916.pdf 0 9 separator 0.9789249 ¶ 724 726 W2264287916.pdf 0 10 text 0.5732937 Keywords : 726 738 W2264287916.pdf 0 11 bibliography 0.43101266 Binary 738 744 W2264287916.pdf 0 12 text 0.53772944 pulsars; tests of gravity; Lorentz breaking; quantum gravity. 744 806 W2264287916.pdf 0 13 separator 0.9973418 ¶ 806 808 W2264287916.pdf 0 14 title 0.98635924 1. Introduction 808 824 W2264287916.pdf 0 15 separator 0.9950565 ¶ 824 826 W2264287916.pdf 0 16 text 0.9956039 "General Relativity (GR) is living a golden era of continuous veri cations of its predictions, at many scales and in very dierent processes1{3. The agreement of data with GR predictions is both astonishing (given the range of scales probed) and disappointing (GR is not a complete quantum theory, but the experimental guidance towards its completion is scarce). One hopes that the synergy between the experimental and theoretical eorts will unveil the remaining mysteries of gravitation. In this note I shall illustrate this by working with a concrete model motivated by quantum gravity, Lorentz violating (LV) gravity, and that modi es the predictions of GR at basically all scales. I will describe the model and focus on the predictions for binary pulsars." 826 1604 W2264287916.pdf 0 17 separator 0.638819 ¶ 1604 1606 W2264287916.pdf 0 18 text 0.99592286 For more information, the reader is invited to consult the recent review article4. 1606 1689 W2264287916.pdf 0 19 separator 0.9966527 ¶ 1689 1691 W2264287916.pdf 0 20 title 0.99456024 2. Lorentz violating gravity as a theory of modi ed gravity 1691 1751 W2264287916.pdf 0 21 separator 0.9958209 ¶ 1751 1753 W2264287916.pdf 0 22 text 0.995185 "The number of theories of gravity beyond GR has experienced a remarkable recent expansion. This was driven by the new data, the continuous search for theories that may solve the shortcomings of GR and the advances in the methods to work in problems related to gravitation. The attempt to classify the dierent approaches has produced a relatively complex map of possibilities1{3. Instead of classifying them, one can simply confront them with the following list of desirable properties for a theory modifying GR: (i) Represent/break a fundamental principle of gravity/Nature. (ii) Improve the short distance properties of GR (ideally addressing the problems of quantum gravity and/or singularities). (iii) Provide new ideas for cosmic acceleration or dark matter. (iv) Produce a (testable) interesting phenomenology.arXiv:1601.04653v1 [gr-qc]" 1753 2619 W2264287916.pdf 0 23 paratext 0.9866588 18 Jan 2016 2620 2632 W2264287916.pdf 0 0 text 0.9976333 "there is still a long way to go before we can translate them into new strategies to characterize, treat and monitor blood cancer.To achieve this translational challenge, many considerationsshould be taken into account." 0 220 W3123789140.pdf 5 1 separator 0.9793385 ¶ 220 222 W3123789140.pdf 5 2 text 0.99960876 "First, reliably identifying noncoding driver mutations from passenger ones remains a great endeavor due to sequencing and mapping artifacts, poorly understood mutational processes, and inaccurate estimation of the mutational background. To facethese impediments, adequate statistical methods, larger datasets,higher sequence coverage, and longer and more accuratesequencing reads will be fundamental. In addition, thesequencing of normal tissues alongside malignant ones can help separate acquired from germline mutations and shed light on differentiating driver from passenger mutations." 222 821 W3123789140.pdf 5 3 separator 0.9121532 ¶ 821 823 W3123789140.pdf 5 4 text 0.9996765 "Second, given the vastness of the noncoding genome, we need to restrict the search to relevant noncoding driver mutations. Tothis end, comparative genomic analysis, high-throughput in vitro reporter assays, and genome-wide histone modi fication pro filing, coupled with chromatin accessibility and expression analysis, are indispensable. However, due to the highly dynamic, cell- andstimulus-speci fic nature of regulatory regions, it is critical to identify the right cell-type and to extend this descriptiveinterrogation not only to the cells of origin but also to thetransformed cells." 823 1419 W3123789140.pdf 5 5 separator 0.95640254 ¶ 1419 1421 W3123789140.pdf 5 6 text 0.9996019 "Third, the unknown functional role of noncoding mutations imposes important limitations. To ascertain biological and mechanistic relevance, it is essential to integrate genetic andepigenetic pro filing with genome conformation data and CRISPR-based functional validation. As previouslydescribed, many noncoding mutations map to enhancers, andthese can exert their pathological function by altering the expression level of their target genes. However, connecting enhancers and target genes is not trivial, and due to cell-speci ficity and complexity, most of the associations remain unknown. Quantitative associations between noncoding variantsand gene expression, and regulatory biochemical propertiescombined with sequencing-based chromatin conformationcapture methods, such as Hi-C ( 24), have started providing some insights. However, reliable and reproducible identi fication of signi ficant interactions between individual restriction fragments is not feasible unless Hi-C libraries are subjected to ultra-deepsequencing, which is not an economically viable solution foranalyzing a comprehensive collection of cell-types or tumoralsamples. To overcome it, the development of sequence-speci fic capturing approaches to enrich for promoter interactions and mutations in Hi-C libraries ( 6,11,69,85), or other methods suchas ChIA-PET ( 92)o rH i C h I P( 93), is crucial. Nonetheless, all these methods need millions of cells, which hinders the analysis of rarecell populations such as hematopoietic stem cells or hematopoieticprecursors, which are the origin cells of the majority of leukemias.Methodological breakthroughs allowing lower inputs will befundamental in the incipient era of noncoding driver mutations." 1421 3159 W3123789140.pdf 5 7 separator 0.993215 ¶ 3159 3161 W3123789140.pdf 5 8 text 0.9996113 "In conclusion, the current methodological breakthroughs have positioned the scienti fic community in a perfect situation to explore the noncoding genome in the context of cancer. Cancergenomics is rapidly moving from a static, one-dimensionalpicture, to a time-dependent three-dimensional scenario toprovide biological relevance of noncoding mutations at regulatory elements. We anticipate a very exciting time ahead, in which we will be fascinated by the power of noncoding mutationsand epimutations in malignant transformation and the newclinical opportunities these genetic alterations will involve." 3161 3771 W3123789140.pdf 5 9 separator 0.9967897 ¶ 3771 3773 W3123789140.pdf 5 10 title 0.9900981 AUTHOR CONTRIBUTIONS 3773 3794 W3123789140.pdf 5 11 separator 0.9940661 ¶ 3794 3796 W3123789140.pdf 5 12 text 0.99713886 All authors listed have made a substantial, direct, and intellectualcontribution to the work and approved it for publication. 3796 3922 W3123789140.pdf 5 13 separator 0.9953393 ¶ 3922 3924 W3123789140.pdf 5 14 title 0.9876705 FUNDING 3924 3932 W3123789140.pdf 5 15 separator 0.9938467 ¶ 3932 3934 W3123789140.pdf 5 16 text 0.9993119 "LR is funded by AGAUR project number 2019FI-B00017 of theCatalan Government (Generalitat de Catalunya). AR-M isfunded by the Jose ́Carreras Leukämie-Stiftung (08R/2019). BJ is funded by FEDER/Spanish Ministry of Science and Innovation(project number RTI2018-094788-A-I00), by La Caixa BankingFoundation Junior Leader project (LCF/BQ/PI19/11690001), by the Jose ́Carreras Leukämie-Stiftung (08R/2019), and by the European Hematology Association Advance Research Grant.The funder bodies were not involved in the study design,collection, analysis, interpretation of data, the writing of thisarticle or the decision to submit it for publication." 3934 4582 W3123789140.pdf 5 17 separator 0.99653596 ¶ 4582 4584 W3123789140.pdf 5 18 title 0.9887102 ACKNOWLEDGMENTS 4584 4600 W3123789140.pdf 5 19 separator 0.9945979 ¶ 4600 4602 W3123789140.pdf 5 20 text 0.9981364 We apologize to the authors of many relevant studies for notciting their work due to space limitations. We thank themembers of the Javierre laboratory for helpful discussion andChristina Usher for her editing suggestions. 4602 4824 W3123789140.pdf 5 21 separator 0.99691045 ¶ 4824 4826 W3123789140.pdf 5 22 title 0.964633 REFERENCES 4826 4837 W3123789140.pdf 5 23 separator 0.9950379 ¶ 4837 4839 W3123789140.pdf 5 24 bibliography 0.9979913 "1. Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, et al. Systematic localization of common disease-associated variation in regulatory DNA. Sci (80- ) (2012) 337(6099):1190 –5. doi: 10.1126/science. 1222794" 4839 5066 W3123789140.pdf 5 25 separator 0.96091825 ¶ 5066 5068 W3123789140.pdf 5 26 bibliography 0.99782765 "2. Khurana E, Fu Y, Chakravarty D, Demichelis F, Rubin MA, Gerstein M. Role of non-coding sequence variants in cancer. Nat Rev Genet (2016) 17:93 –108. doi: 10.1038/nrg.2015.173. Weinhold N, Jacobsen A, Schultz N, Sander C, Lee W. Genome-wide analysis of noncoding regulatory mutations in cancer. Nat Genet (2014) 46(11):1160 – 5. doi: 10.1038/ng.3101" 5068 5428 W3123789140.pdf 5 27 separator 0.97693044 ¶ 5428 5430 W3123789140.pdf 5 28 bibliography 0.9978521 "4. Farh KKH, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, et al. Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature (2015) 518(7539):337 –43. doi: 10.1038/nature13835" 5430 5641 W3123789140.pdf 5 29 separator 0.96301717 ¶ 5641 5643 W3123789140.pdf 5 30 bibliography 0.99758744 "5. Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-Andre ́V, Sigova AA, et al. Super- enhancers in the control of cell identity and disease. Cell(2013) 155(4):934. doi: 10.1016/j.cell.2013.09.053Rovirosa et al. Noncoding Mutations in Blood Cancer" 5643 5888 W3123789140.pdf 5 31 separator 0.97414505 ¶ 5888 5890 W3123789140.pdf 5 32 paratext 0.97955805 Frontiers in Immunology | www.frontiersin.org October 2020 | Volume 11 | Article 592087 6 5890 5980 W3123789140.pdf 5 0 paratext 0.96803933 Fuyu Hu et al. 0 14 W4306990214.pdf 1 1 separator 0.77354884 ¶ 14 16 W4306990214.pdf 1 2 title 0.7176168 RESEARCH 16 25 W4306990214.pdf 1 3 paratext 0.40861306 25 26 W4306990214.pdf 1 4 title 0.89659894 "¶ Relational Topology-based Heterogeneous Network Embedding for Predicting Drug-Target Interactions" 26 129 W4306990214.pdf 1 5 separator 0.9785558 ¶ 129 131 W4306990214.pdf 1 6 contact 0.98353285 "Fuyu Hu1, Chunping Ouyang1,2*, Yongbin Liu1,2, Zheng Gao3and Yaping Wan1,2 *Correspondence: ouyangcp@126.com" 131 244 W4306990214.pdf 1 7 separator 0.8285357 ¶ 244 246 W4306990214.pdf 1 8 contact 0.9809784 "1School of Computer, University of South China, Hengyang,Hunan, 421001, China 2Hunan provincial base for scientific and technological, Innovation Cooperation, Hengyang,Hunan, 421001, China" 246 446 W4306990214.pdf 1 9 separator 0.9330709 ¶ 446 448 W4306990214.pdf 1 10 text 0.5932745 "Full list of author information is available at the end of the article" 448 521 W4306990214.pdf 1 11 paratext 0.38225436 Abstract 521 529 W4306990214.pdf 1 12 separator 0.9924382 ¶ 529 531 W4306990214.pdf 1 13 text 0.99943846 "Background: Predicting interactions between drugs and target proteins is a k ey task in drug discovery. Although the method of validation via wet- lab experiments has become available, experimental methods for drug-target interactions (DTIs) identification remain either time consumi ng or heavily dependent on domain expertise. Therefore, various computationa l models have been proposed to predict possible interactions between drugs and target proteins." 531 997 W4306990214.pdf 1 14 separator 0.81409466 ¶ 997 999 W4306990214.pdf 1 15 text 0.99968183 "Usually, we construct a heterogeneous network with drugs and targe t proteins to calculate the relationship between them. However, most calcu lation methods do not consider the topological structure of the relationship between d rugs and target proteins. Fortunately, Network Embedding Learning pr ovides new and powerful graph analytical approaches for predicting drug-tar get interaction, which is considering both content and topology of network." 999 1459 W4306990214.pdf 1 16 separator 0.9719188 ¶ 1459 1461 W4306990214.pdf 1 17 text 0.9996584 "Results: In this article, we propose a relational topology-based heterogeneous network embedding method to predict DITs, abbreviated as RT HNEDTI. We use the ideas of word embeddings to turn heterogeneous network wit h drugs and target proteins into dense, low-dimensional real-valued vect ors. Furthermore, according to two different topological structure of the relationsh ip between the nodes, we represent them separately by training two differen t models.Then the meaningful vectors represented for drugs and target proteins ca n be used to calculate the interaction of them easily. Results show that by considering topological structure and different relationship type of drugs and t arget proteins, RTHNEDTI outperforms other state-of-the-art methods on both labeled n etwork and unlabeled network." 1461 2284 W4306990214.pdf 1 18 separator 0.9393235 ¶ 2284 2286 W4306990214.pdf 1 19 text 0.99944437 "Conclusions: This work proposes heterogeneous network representation learning for DITs prediction. To the best of our knowledge, this s tudy first introduces relation classification to heterogeneous network emb edding to improve predicting DTIs efficiently." 2286 2546 W4306990214.pdf 1 20 separator 0.99320996 ¶ 2546 2548 W4306990214.pdf 1 21 text 0.382276 Keywords: Link prediction; Heter 2548 2581 W4306990214.pdf 1 22 title 0.30593196 ogeneous 2581 2589 W4306990214.pdf 1 23 text 0.3931474 information network; Drug 2589 2615 W4306990214.pdf 1 24 title 0.3304751 - 2615 2616 W4306990214.pdf 1 25 text 0.34549052 target 2616 2622 W4306990214.pdf 1 26 title 0.31768548 2622 2623 W4306990214.pdf 1 27 paratext 0.30417904 ¶ 2623 2624 W4306990214.pdf 1 28 title 0.35393733 2624 2625 W4306990214.pdf 1 29 paratext 0.3957339 interaction 2625 2636 W4306990214.pdf 1 30 separator 0.9920955 ¶ 2636 2638 W4306990214.pdf 1 31 title 0.95334405 Introduction 2638 2651 W4306990214.pdf 1 32 separator 0.9938936 ¶ 2651 2653 W4306990214.pdf 1 33 text 0.9995093 "The prediction of drug-target interactions (DTIs) is the key to the d evelopment of new drugs. It plays an important role in the study of drug toxicity and side effects and in the treatment of diseases. However, traditional methods based on large-scale biological experiments usually take several years and are often very exp ensive [1]." 2653 2996 W4306990214.pdf 1 34 separator 0.6681155 ¶ 2996 2998 W4306990214.pdf 1 35 text 0.99957365 "In recent years, with the rapid development of computer technology and the accu- mulation of large amounts of medical data, methods such as machine learning an d" 2998 3162 W4306990214.pdf 1 0 paratext 0.95964223 23 0 2 W4230531551.pdf 23 1 separator 0.99470675 ¶ 4 6 W4230531551.pdf 23 2 text 0.99899054 "The network lifetime is determined by the ratio of confirmed acknowledgment to the whole number of possible node transmissions on reaching the prescribed Trust Values (TV). In this research, the time is fixed on the first packet transmission. At the end of the session, the consolidated time interval is calculated. This time length is compared to the individual packet transmission and acknowledgment time interval. At each time, the interval time is noted and recorded to the past interaction history. In this instant, the time consumption for the current packet is calculated concerning the amount of energy spent on the REQ/REP process [8] [15] [41]. This process is expressed as the following process ," 6 732 W4230531551.pdf 23 3 separator 0.9834959 ¶ 734 736 W4230531551.pdf 23 4 text 0.9975701 The Network Lifetime (NLT) of Packet (Pkt) at nth node is carried out by following equation 8, 736 831 W4230531551.pdf 23 5 separator 0.7003719 ¶ 832 834 W4230531551.pdf 23 6 math 0.94482636 "NLT (S ↔ D )=Energy 1st pkt tran(t) − (Energy nth pkt tran(t) ) Energy total pkt tran(t) − (Energy nth pkt tran(t) ) (8)" 834 960 W4230531551.pdf 23 7 separator 0.9905015 ¶ 961 963 W4230531551.pdf 23 8 text 0.9983764 "Meanwhile, the Bytes per Symbol information(BpS) is calculated based on the data transfer rates. The two parameters that access the BpS are connection strength and packet speeds. If the participating mobile node quantity is increased, the packet delivery speed also is dramatically increased. In the MANET transmission, the Bytes per Symbol information(BpS) calculation is in symbols per second (i.e., Data rate in BpS × 204) / (188 × BpS). To convince this byte per Symbol information(BpS), this research can be used in the Hybrid Random Late Detection (HRLD) routing protocol [59], which is constituted based on the past interaction history with route interaction from network id 0.0.0.1. to an end-user node [30] [32]." 963 1703 W4230531551.pdf 23 9 separator 0.96576643 ¶ 1705 1707 W4230531551.pdf 23 10 text 0.9995943 "While a packets transmission between the origin of the Hybrid Random Late Detection (HRLD) routing protocol and end-user occurs, the proactive protocol gets activated for speeding up the packet delivery by using inspected nodes and its route at the same time. This proactive protocol manages the immediate packet delivery to nearby nodes without any rush and improves the end- to-end delay time called random late detection. To carry the packet without rush, broadcasting packets using random exact minimal path rectification proficiency is utilized. In MANET, the nearby nodes will change their location due to the node movements aspect. At that time, the routes availability and destination node are switched in the random detection zone." 1707 2467 W4230531551.pdf 23 11 separator 0.89205426 ¶ 2469 2471 W4230531551.pdf 23 12 text 0.99916416 "This same procedure is extended to another group to enhance routing protocol on each successive zone [42]. These techniques help to find transmission acceleration of the network irrespective of whether the node transmits the data or not. The transmission speed is found based on the following node transmission accelerate (shown in table.7). Node transmission range patterns are formed by increasing the packet delivery ratio of the individual node and reduce packet delay on selected routes from the past interaction history [55] [60]. Once a nodes route is established without any intrusion, the destination node path will be stored in the node transmission that accelerates the table using the proactive protocol. This sequential transmission acceleration and address are always used to deliver the packet for the next sequential node [43] ." 2471 3337 W4230531551.pdf 23 13 separator 0.99685526 ¶ 3339 3341 W4230531551.pdf 23 14 title 0.9747189 Table 7. Node transmission accelerate tab le 3341 3386 W4230531551.pdf 23 15 table 0.5436882 3387 3388 W4230531551.pdf 23 16 separator 0.53787845 ¶ 3388 3389 W4230531551.pdf 23 17 table 0.92540276 "Network Id Next Hop Current Node To Gateway Cost No of Nodes presented No.of. Route on The Gateway Network Destination Net Mask Gateway Interface Metric 0.0.0.1 0.0.0.10 192.130.10.10 192.130.10.0 n 1 to N(n-1)*n R1 125.0.0.0 232.0.0.10 197.1.1.10 197.120.10.10 n 1 to N(n-1)*n R2 .. .. .. .. .. .. .. .. .. .. .. .. .. .. 198.162.0.1 255.255.255.255 198.162.0.100 198.162.0.142 n 1 to N(n-1)*n Rr" 3389 3837 W4230531551.pdf 23 18 separator 0.9693721 ¶ ¶ 3838 3844 W4230531551.pdf 23 19 text 0.9995786 "The intrusion with respect to the packet transmission is observed using the node transmission acceleration table switching technique. Here, the packet sent over to the neighbor group or the nearby controller would be based on the key assignment, past interaction. [5] [39]. After forming the node transmission accelerate table, the MANET ratio range rate would be activated based on data transmission, networking, and protocols. The data transmission protocols are derived from the following algorithms and used to activate the MANET ratio range." 3844 4403 W4230531551.pdf 23 0 paratext 0.98945224 Int. J. Environ. Res. Public Health 2020 ,17, 1352 3 of 11 0 58 W3007927474.pdf 2 1 separator 0.99494714 ¶ 58 60 W3007927474.pdf 2 2 text 0.9992643 "The process of data collection and analysis was iterative. All interviews were transcribed, and the resulting transcripts were imported into NVivo 12 [ 19] and subjected to thematic analysis. The data analysis was mainly inductive and followed the four steps described by Green and colleagues: immersion in the data; coding; creating categories; and identifying themes [ 20]. Transcripts were read and coded separately by the research team, and a list of codes was developed and refined as coding progressed [ 21]. The conceptual framework by Pfarrwaller and colleagues—specifically the central part of the model [15]—was used to guide the interpretation of the data, the research team agreed on the main themes. Rigour was enhanced through investigator triangulation, through team member checking, coding validation, peer debriefing [22], and the use of NVivo [23]." 60 940 W3007927474.pdf 2 3 separator 0.99729234 ¶ 940 942 W3007927474.pdf 2 4 title 0.9849932 3. Results 942 953 W3007927474.pdf 2 5 separator 0.996143 ¶ 953 955 W3007927474.pdf 2 6 title 0.99052733 3.1. Sample 955 967 W3007927474.pdf 2 7 separator 0.995934 ¶ 967 969 W3007927474.pdf 2 8 text 0.9988061 A total of 21 participants were interviewed; their characteristics are shown in Table 1. 969 1058 W3007927474.pdf 2 9 separator 0.9957471 ¶ 1058 1060 W3007927474.pdf 2 10 title 0.85947216 Table 1. Interview participant—main sample characteristics. 1060 1120 W3007927474.pdf 2 11 separator 0.9833342 ¶ 1120 1122 W3007927474.pdf 2 12 table 0.9950735 "Characteristic Sub-Group Total Total Sex Female 11 Male 10 Total 21 PG Year (at interview)PGY1 PGY24 4 PGY3 8 PGY4 3 PGY5 2 Total 21 Rural Background Yes 11 No 10 Total 21 RCS Participation Yes 14 No 7 Total 21 Specialist Intention GP 7 Non-GP 8 Unsure 6 Total 21 Age Group 25-30 17 31-40 4 Total 21" 1122 1468 W3007927474.pdf 2 13 separator 0.54702854 ¶ 1468 1470 W3007927474.pdf 2 14 table 0.9619526 PGY: Postgraduate Year. RCS: Rural Clinical School. GP: General Practitioner. 1470 1548 W3007927474.pdf 2 15 separator 0.9960387 ¶ 1548 1550 W3007927474.pdf 2 16 title 0.9910223 3.2. Themes 1550 1562 W3007927474.pdf 2 17 separator 0.996095 ¶ 1562 1564 W3007927474.pdf 2 18 text 0.99599785 "Two main themes were identified: (1) career decision making as an on-going process and (2) exploration versus planning in career-decision making. These themes are discussed below and are illustrated with contextualised quotes. Sites have been omitted to maintain confidentiality." 1564 1846 W3007927474.pdf 2 19 separator 0.99616385 ¶ 1846 1848 W3007927474.pdf 2 20 title 0.9918668 Career Decision Making as an On-Going Process 1848 1894 W3007927474.pdf 2 21 separator 0.993747 ¶ 1894 1896 W3007927474.pdf 2 22 text 0.999509 "Overall, career decision making emerged as a dynamic and continuous process. Most doctors in our study were still making career decisions regarding speciality or future practice location at the time of the interview, and change featured strongly in their descriptions of their careers. There was evidence of change of career intention from medical school among the majority of our junior doctors, and this was strongly influenced by exposure to di erent specialties and to rural practice." 1896 2393 W3007927474.pdf 2 0 paratext 0.9907958 Page 21/23 0 10 W4385810950.pdf 20 1 separator 0.99570787 ¶ 10 12 W4385810950.pdf 20 2 caption 0.7418017 Figure 8 12 21 W4385810950.pdf 20 3 separator 0.986009 ¶ 21 23 W4385810950.pdf 20 4 caption 0.8095341 Comprehensive analysis of SLC25A3, LOXL2 expression and immune checkpoints. 23 99 W4385810950.pdf 20 5 separator 0.9895161 ¶ 99 101 W4385810950.pdf 20 6 caption 0.9896756 Box plot comparing immune checkpoints expression between SLC25A3high and SLC25A3low groups (A), 101 197 W4385810950.pdf 20 7 separator 0.49615812 ¶ 197 199 W4385810950.pdf 20 8 caption 0.9927402 and LOXL2high and LOXL2low groups (B) in LUAD patients. 199 255 W4385810950.pdf 20 0 paratext 0.98488086 Page 32/32 0 10 W4395662508.pdf 31 1 text 0.77312803 This is a list of supplementary 10 41 W4395662508.pdf 31 0 separator 0.610101 "¶ ¶ ¶" 1 14 W4226229063.pdf 4 1 paratext 0.9617214 "Revista MultiAtual - v.3, n.4 (2022) - Abril (2022) 102 ¶ Revista MultiAtual - ISSN 2675 -4592 Periódico Científic o Indexado Internacionalmente www.multiatual.com.br" 14 205 W4226229063.pdf 4 2 separator 0.8988765 ¶ ¶ 207 213 W4226229063.pdf 4 3 text 0.9980422 "O comprimento de onda na faixa da luz visível vermelha (625nm a 700nm) apresenta como efeitos a proliferação celular, atividade antiflamatória, analgesia, angiogênese e redução de edema, melhorando o aspecto físico devido a uma melhora da nutrição tecidual (VIEIRA, 2020)." 215 497 W4226229063.pdf 4 4 separator 0.5820074 ¶ 499 501 W4226229063.pdf 4 5 text 0.9989447 "A absorção da luz vermelha ocorre pelo citocromo c oxidase, desencadeando como efeitos o favoreciment o da mobilidade iônica, levando ao aumento do potencial de membrana mitocondrial, consumo de oxigênio, síntese de ATP (trifosfato de adenosina), espécies reativas de oxigênio e liberação de óxido nítrico (NO) (AVCI, 2013)." 501 838 W4226229063.pdf 4 6 separator 0.9558747 ¶ 840 842 W4226229063.pdf 4 7 text 0.99030054 "A associação das técnicas de ele trolipólise e fototerapia na redução da lipodistrofia localizada, denominou -se de eletrofotolipólise. Diante disto, o objetivo deste estudo foi analisar a eficácia na redução da lipodistrofia localizada abdominal utilizando a técnica de eletrofotolipólise." 842 1143 W4226229063.pdf 4 8 separator 0.993135 ¶ ¶ 1145 1151 W4226229063.pdf 4 9 title 0.99027807 METODOLOGIA 1151 1163 W4226229063.pdf 4 10 separator 0.99602365 ¶ 1165 1167 W4226229063.pdf 4 11 text 0.9993904 "Trata -se de um estudo clínico e qualitativo para investigação da eficácia da redução da lipodistrofia localizada pela técnica de eletro fotolipólise, realizado na Clínica de Estética, FCS, da Universidade do Vale do Paraíba - UNIVAP, aprovado pelo Comitê de Ética em Pesquisa sob o parecer consubstanciado no 4.572.373." 1167 1499 W4226229063.pdf 4 12 separator 0.96910834 ¶ 1501 1503 W4226229063.pdf 4 13 text 0.9975654 "Na técnica de eletrolipólise utilizou -se o equipamento Cel Lyse da DGM Eletrônica, o qual possui uma corrente polarizada e frequência de 15Hz. A intensidade aplicada da corrente foi variável entre 1,0 e 3,0 mA (miliampère), de acordo com o limite suportado por cada participante." 1503 1794 W4226229063.pdf 4 14 separator 0.8417263 ¶ 1796 1798 W4226229063.pdf 4 15 text 0.9976276 "Para aplicação da fototerapia utilizou -se o equipamento Elite -Olympus da DMC Equipamentos, com os seguintes parâmetros: para fototipos I e II utilizou -se 3J (Joule) de energia; para fototipos III e IV utilizou -se 2J de energia; com densidade de 100J/cm2 de energia no comprimento de onda de 660 nm." 1798 2111 W4226229063.pdf 4 16 separator 0.97243845 ¶ 2113 2115 W4226229063.pdf 4 17 text 0.9917428 "Para seleção das participantes foi feito convite no hall de entrada das clínicas da área da saúde. Após o acei te inicial, a participante foi conduzida para uma área reservada para maiores explicações, apresentação do TCLE e ficha de anamnese. Em seguida, as participantes foram agendadas para avaliação e início do procedimento." 2115 2457 W4226229063.pdf 4 0 paratext 0.9643882 ¶ Jurnal Buana Farma Vol . 1 No . 3 (2021 ) 1 44 W3208003408.pdf 0 1 separator 0.8884245 ¶ 45 47 W3208003408.pdf 0 2 title 0.96908545 "31 EVALUASI PENGOBATAN INFEKSI SALURAN PERNAPASAN AKUT PADA BALITA DI KLINIK X CIKARANG UTARA" 48 146 W3208003408.pdf 0 3 separator 0.98881465 ¶ ¶ 148 154 W3208003408.pdf 0 4 contact 0.9913939 "1 Hairul Iksan,2 Dedy Frianto,3Maulana Yusuf Alkandahri 1,2,3Fakultas Farmasi Universitas Buana Perjuangan, Karawang , Indonesia Corresponding author: fm17.hairuliksan @mhs.ubpkarawang.ac.id" 154 355 W3208003408.pdf 0 5 separator 0.52536416 357 358 W3208003408.pdf 0 6 contact 0.56149065 ¶ 358 359 W3208003408.pdf 0 7 separator 0.91559935 ¶ ¶ 361 367 W3208003408.pdf 0 8 title 0.9854548 Abstrak 367 375 W3208003408.pdf 0 9 separator 0.9934079 ¶ 377 379 W3208003408.pdf 0 10 text 0.998023 "Infeksi saluran pernapasan akut adalah penyakit yang disebabkan oleh berbagai macam mikrorganisme dan dapat menyebabkan Infeksi. Infeksi saluran pernapasan akut (ISPA) adalah infeksi yang paling banyak terjad i pada manusia di segala umur. Anak -anak dan balita merupakan yang paling rentan dan banyak terkena ISPA .Penelitian ini dilakukan secara analitik observasional dengan jenis dekskriptif, dengan pendekataan secara cross sectional d an metode pengambilan data secara prospektif . Berdasarkan penelitian yang telah dilakukan di Klinik X Cikarang Utara dengan judul ”Evaluasi pengobatan infeksi saluran pernapasan akut pada balita di klinik X Cikarang Utara” pasien balita dengan jenis kelamin laki -laki lebih banyak ji ka dibandingkan pasien perempuan. pengobatan" 379 1171 W3208003408.pdf 0 11 separator 0.95238674 ¶ 1173 1175 W3208003408.pdf 0 12 text 0.99868274 "Antibiotik yang paling banyak digunakan adalah cefadroxil (57 %) dan untuk pengobatan suportif yang paling banyak digunakan adalah Ambroxol (21,7%) , dari hasil evaluasi tedapat 3 pengobatan dengan dosis yang bel um sesuai dengan pedoman yaitu Dexa- methasone,Methylprednisolo ne, dan Cefixime sedangkan pengobatan lainnya sudah sesuai dengan pedoman berdasarkan standar Pharmaceutical care untuk Penyakit Infeksi Saluran Pernapasan dan Formularium spesialistik Ilmu Kesehatan Anak (DEPKES RI), Model formulary for children (WHO) dan pharmacotherapy handbook 9th dan d ari hasil evaluasi tidak ditemukan korelasi antara angka kunjungan pasien dengan kesesuaian dosis pengobatan ." 1175 1874 W3208003408.pdf 0 13 separator 0.9458786 ¶ 1875 1877 W3208003408.pdf 0 14 text 0.55344474 Kata kunci :Infeksi saluran per 1877 1911 W3208003408.pdf 0 15 bibliography 0.35764644 napas 1911 1916 W3208003408.pdf 0 16 text 0.42580584 an akut, Pharmaceutical care 1916 1944 W3208003408.pdf 0 17 bibliography 0.438977 untuk Penyakit Infeksi Saluran Pernapasan , 1944 1988 W3208003408.pdf 0 18 text 0.49496493 formulary for chil- 1988 2008 W3208003408.pdf 0 19 bibliography 0.36934072 2008 2009 W3208003408.pdf 0 20 text 0.45313194 ¶ dren, dan pharmacotherapy handbook 9th 2009 2050 W3208003408.pdf 0 21 separator 0.9965552 ¶ 2051 2053 W3208003408.pdf 0 22 title 0.9337451 Abstract 2053 2062 W3208003408.pdf 0 23 separator 0.99537253 ¶ 2064 2066 W3208003408.pdf 0 24 text 0.99950343 "Acute respiratory infection is a disease caused by various kinds of microorganisms and can cause infection. A cute respiratory infections (ARI) are the most common infections in humans at all ages. Children and toddlers are the most vulnerable and most affected by ARI. . This research was conducted analytically with observational descriptive type, with a cross sec tional approach and prospective data collection methods. Based on research that has been conducted at the X Clinic in North Cikarang with the title ""Evaluation of treatment for acute respiratory infections in children under five at the X Clinic in North Ci karang,"" there are more male children under five than female patients. cefadroxil (57%) and for supportive treatment the most widely used was Am- broxol (21.7%), from the evaluation results there were 3 treatments with doses that were not in accordance with the guidelines, namely Dexamethasone, Methylprednisoloe, and Cefixime, while other treatments were in accordance with the guidelines. Based on Pharmaceutical care standards for Respiratory Tract Infections and Specialist Formulary for Children's Health Sci ences (DEP- KES RI), Formulary Model for Children (WHO) and Pharmacotherapy Handbook 9th and from the evaluation results, no correla- tion was found between the number of patient visits and the suitability of the treatment dose." 2066 3463 W3208003408.pdf 0 25 separator 0.9755907 ¶ 3465 3467 W3208003408.pdf 0 26 bibliography 0.5611582 "Keywords : Acute respiratory in fection, ARI, Pharmaceutical care for Respiratory Tract Infection formulary for children, and 9th handbook pharmacotherapy" 3467 3626 W3208003408.pdf 0 27 separator 0.995889 ¶ ¶ 3628 3634 W3208003408.pdf 0 28 title 0.99001044 PENDAHULUAN 3634 3646 W3208003408.pdf 0 29 separator 0.99520254 ¶ 3649 3651 W3208003408.pdf 0 30 text 0.99824816 "Infeksi Saluran Pernapasan Akut (ISPA) ialah pen- yakit yang terjadi pada saluran pernapasan yang bersifat intens dan menimbulkan beberapa efek samping (kon- disi), Penyakit Saluran Pernapasan Akut (ISPA) bisa disebabkan oleh infeksi atau mikroba (Widoyono, 2011). ISPA yang tidak ditangani dengan baik akan masuk ke jaringan paru -paru dan menjadi penyebab utama ke- matian pada bayi dan anak kecil (Widoyono, 2011). ISPA merupakan masalah medis penting yang biasa ditemukan di Indonesia dan merupakan pen yebab kematian tertinggi pada balita (Rustandi, 2011) . pada tahun 2018 di Indone- sia kasus ISPA terbesar terdapat di provinsi Nusa Tenggara Timur (NTT) sebesar 15 %, dan prevalensi ISPA pada provinsi Jawa Barat sebesar 12 % (Riskesdas, 2018). Berdasarkan pe nelitian dimana dikerjakan oleh Antoro (2015) Antibiotik dimana paling banyak diberi- kan untuk pasien Infeksi Saluran Pernapasan Atas Akut (ISPaA) ialah antibiotik amoksisilin sebesar 83,63% dan kotrimoksazol 16,37%. Dari penelitian tersebut 46,37% pengobatan tidak tepat obat, pasien tidak tepat indikasi sebanyak 34,50% , dan 20,91% pasien tidak tepat dosis." 3651 4842 W3208003408.pdf 0 31 separator 0.71516985 ¶ 4843 4845 W3208003408.pdf 0 32 text 0.99951833 "Pada penelitian tersebut penggunaan antibiotik yang ra- sional mencapai 42,72% . %. Dalam penelitian lain yang dilakukan Annisa (2017) . dari penelitian ini mendapat konsekuensi penalaran sesuai batas ( Tepat indikasi , tepat obat, tepat pasien , tepat dosis ) sebanyak 15 kasus (31,9%) dan pengobatan yang tidak tepat sebanyak 32 kasus (68,1%) (Annisa, 2017). Satu lagi penelitian yang diarahkan oleh Ladipa pada tahun 2016 dari 115 kasus terlacak jika 16 kasus pengobatan sudah tepat (13,91%), sedangkan 99 kasus tidak tepat (86,09%) (Ladipa, 2018). Pengobatan yang efektif dan efisien merupakan hal dimana penting dalam mengontrol meningkatnya" 4845 5528 W3208003408.pdf 0 0 paratext 0.95895267 26 0 2 W4313455972.pdf 25 1 separator 0.8789046 ¶ 3 5 W4313455972.pdf 25 2 title 0.7441426 Reference s 6 18 W4313455972.pdf 25 3 paratext 0.54892 540 18 22 W4313455972.pdf 25 4 separator 0.86140317 ¶ 23 25 W4313455972.pdf 25 5 bibliography 0.98648906 " Brooks, S., Luke, W., Cohen, M., Kelly, P., Lefer, B., and Rappenglück, B. J. A. E.: Mercury species 541 measured atop the Moody Tower TRAMP site, Houston, Texas, 44, 4045 -4055, 2010. 542  Chai, T., Stein, A., Ngan, F., and Draxler, R.: Inverse modeling with HYSPLIT Lagrangian 543 Dispersion Model -Tests and Evaluation using the Cross Appalachian Tracer Experiment 544 (CAPTEX) data, AGU Fal l Meeting Abstracts, 2016. 545 " 25 470 W4313455972.pdf 25 6 separator 0.5335163 ¶ 470 471 W4313455972.pdf 25 7 bibliography 0.988948 " Chai, T., Crawford, A., Stunder, B., Pavolonis, M. J., Draxler, R., and Stein, A.: Improving volcanic 546 ash predictions with the HYSPLIT dispersion model by assimilating MODIS satellite retrievals, 547 Atmospheric Chemistry and Physics , 17, 2865 -2879, 2017. 548 " 471 748 W4313455972.pdf 25 8 separator 0.6228787 ¶ 748 749 W4313455972.pdf 25 9 bibliography 0.98873055 " Chen, P., Kang, S., Bai, J., Sillanpää, M., and Li, C.: Yak dung combustion aerosols in the Tibetan 549 Plateau: Chemical characteristics and influence on the local atmospheric environment, 550 Atmospheric Research, 156, 58 -66, 10.1016/j.atm osres.2015.01.001, 2015. 551" 749 1030 W4313455972.pdf 25 10 separator 0.6858965 ¶ 1031 1033 W4313455972.pdf 25 11 bibliography 0.9926575 " Cheng, I., Zhang, L., Blanchard, P., Graydon, J., St Louis, V. J. A. C., and Physics: Source - 552 receptor relationships for speciated atmospheric mercury at the remote Experimental Lakes 553 Area, northwestern Ontario, Canada, 12, 1903 -1922, 2012. 554" 1033 1297 W4313455972.pdf 25 12 separator 0.6098808 ¶ 1298 1300 W4313455972.pdf 25 13 bibliography 0.9881438 " Cheng, M., Liu, M., Li, D., Luo, Q., Zhang, Z., Yuan, L., Yu, C., Xie, H., Lin, H., and Zhang, Q.: 555 Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional 556 Tibetan Medicine, Bulletin of Environmental Contamination and Toxicology, 1 -10, 2021. 557" 1300 1597 W4313455972.pdf 25 14 separator 0.79847753 ¶ 1598 1600 W4313455972.pdf 25 15 bibliography 0.9930819 " Ci, Z., Zhang, X., Wang, Z., and Niu, Z.: Atmospheric gaseous elemental mercury (GEM) over 558 a coastal/rural site downwind of East China: temporal variation and long -range transport, 559 Atmospheric Environment, 45, 2480 -2487, 2011. 560" 1600 1850 W4313455972.pdf 25 16 separator 0.7955346 ¶ 1851 1853 W4313455972.pdf 25 17 bibliography 0.9958631 " Cong, Z., Kang, S., Luo, C., Li, Q., Huang, J., Gao, S., and Li, X.: Trace elements and lead isotopic 561 composition of PM10 in Lhasa, Tibet, Atmospheric Environment, 45, 6210 -6215, 2011. 562" 1853 2053 W4313455972.pdf 25 18 separator 0.72860026 ¶ 2054 2056 W4313455972.pdf 25 19 bibliography 0.99640894 " Dommergue, A., Ferrari, C. P., Gauchard, P. A., Boutron, C. F., Poissant , L., Pilote, M., Jitaru, P., 563 and Adams, F. C. J. G. r. l.: The fate of mercury species in a sub ‐arctic snowpack during 564 snowmelt, 30, 2003. 565" 2056 2292 W4313455972.pdf 25 20 separator 0.7427008 ¶ 2293 2295 W4313455972.pdf 25 21 bibliography 0.9964208 " Duan, L., Wang, X., Wang, D., Duan, Y., Cheng, N., and Xiu, G.: Atmospheric mercury speciation 566 in Shanghai, China, S cience of the Total Environment, 578, 460 -468, 2017. 567" 2295 2480 W4313455972.pdf 25 22 separator 0.6283134 ¶ 2481 2483 W4313455972.pdf 25 23 bibliography 0.9843806 " Feng, X., Fu, X., and Zhang, H.: Observations of atmospheric Hg species and depositions in 568 remote areas of China, E3S Web of Conferences, 2013. 569 " 2483 2643 W4313455972.pdf 25 24 separator 0.52365166 ¶ 2643 2644 W4313455972.pdf 25 25 bibliography 0.9894457 " Feng, X., and Fu, X.: Monsoon -facilitated characteristics a nd transport of atmospheric 570 mercury at a high -altitude background site in southwestern China, Atmos. Chem. Phys, 1680, 571 7324, 2016. 572" 2644 2858 W4313455972.pdf 25 26 separator 0.8195229 ¶ 2859 2861 W4313455972.pdf 25 27 bibliography 0.9903259 " Feng, Y., Wang, W., and Liu, J. J. W.: Dilemmas in and Pathways to Transboundary Water 573 Cooperation between China and India on the Yaluzangbu -Brahmaputra River, 11, 2096, 2019. 574" 2861 3053 W4313455972.pdf 25 28 separator 0.7835934 ¶ 3054 3056 W4313455972.pdf 25 29 bibliography 0.99130523 " Fu, X., Feng, X., Zhu, W., Wang, S., and Lu, J.: Total gaseous mercury concentrations in ambient 575 air in the eastern slope of Mt. Gongga, South -Eastern fringe of the Tibetan plateau, China, 576 Atmospheric Envi ronment, 42, 970 -979, 2008. 577" 3056 3313 W4313455972.pdf 25 30 separator 0.8288476 ¶ 3314 3316 W4313455972.pdf 25 31 bibliography 0.9947584 " Fu, X., Feng, X., Liang, P., Zhang, H., Ji, J., and Liu, P.: Temporal trend and sources of speciated 578 atmospheric mercury at Waliguan GAW station, Northwestern China, Atmospheric Chemistry 579 and Physics, 12, 1951 -1964, 2012a. 580" 3316 3561 W4313455972.pdf 25 32 separator 0.8011981 ¶ 3562 3564 W4313455972.pdf 25 33 bibliography 0.9936126 " Fu, X ., Feng, X., Sommar, J., and Wang, S.: A review of studies on atmospheric mercury in 581 China, Science of the Total Environment, 421, 73 -81, 2012b. 582" 3564 3730 W4313455972.pdf 25 34 separator 0.8899218 ¶ 3731 3733 W4313455972.pdf 25 35 bibliography 0.99775535  Fu, X., Marusczak, N., Heimbürger, L. -E., Sauvage, B., Gheusi, F., Prestbo, E. M., and Sonke, J. 583 https://doi.org/10.5194/acp-2022-750 3733 3874 W4313455972.pdf 25 36 separator 0.94796395 ¶ 3874 3876 W4313455972.pdf 25 37 paratext 0.97353274 "Preprint. Discussion started: 7 December 2022 c Author(s) 2022. CC BY 4.0 License." 3876 3961 W4313455972.pdf 25 38 separator 0.9931346 ¶ 3961 3963 W4313455972.pdf 25 0 paratext 0.82145596 6 InternationalJournalofPhotoenergy 0 35 W2341535066.pdf 5 1 separator 0.7677977 ¶ 35 37 W2341535066.pdf 5 2 table 0.9856467 "0 1 12 22 83 23 53 73 94 04 14 24 34 44 44 54 5 01230 20 39 59 7898 117 137 156 176 195 215 234 254 273 293Energy demand covered from PV (%) Installed capacity in PV (GWp) Energy surplus Variability indexRatio (max/mean)0102030405060708090100Energy surplus from PV and variability index (%) Ratio of maximal to mean energy demand" 37 409 W2341535066.pdf 5 3 separator 0.8224442 ¶ 409 411 W2341535066.pdf 5 4 caption 0.981042 Figure7:Photovoltaicsimpactonenergydemandvariability. 411 465 W2341535066.pdf 5 5 table 0.95206815 "¶ 0%10%20%30%40%50%60%70%80%90% 0 100 200 300 400 500 Energy surplus from PVEnergy demand covered from PV Installed capacity in PV (GWp) D_PV_1 D_PV_2D_PV_3 Energy surplusD_PV_3:y = 2.00 10−4x+0.4003 D_PV_2:y = 1.00 10−3x+0.249 0%10%20%30%40%50%60% D_PV_1:y = 53.00 10−4x+0.0065" 465 765 W2341535066.pdf 5 6 separator 0.99252284 ¶ 765 767 W2341535066.pdf 5 7 caption 0.9604244 "Figure8:HowdoesenergydemandcoveredfromPVandresulting energy surpluses change for different values of installed capacity in PV. Key: D PV1 and so forth (denoted by square, triangle, and circle) represent current demand covered from PV; in respective rangestheywereapproximatedbylinearregressionequation." 767 1078 W2341535066.pdf 5 8 separator 0.9896919 ¶ 1078 1080 W2341535066.pdf 5 9 text 0.9389012 "period 2010–2014), the largest increase in PV share incoveringcurrentenergydemandisobservedwheninstalled capacity of PV ranges from 0+ to 50GWp(seeFigure8)." 1080 1239 W2341535066.pdf 5 10 separator 0.9589374 ¶ 1239 1241 W2341535066.pdf 5 11 text 0.9955061 "(iii) Further analysis of increasing installed capacity in PV systems has shown (according to the considereddata) that it is not physically possible to cover morethan53%ofcurrentenergydemandfromPV,without energystoragedevices.SeeonFigure8howslowlythe energy demand is covered from PV increasing wheninstalledcapacityinPVexceeds50GWp." 1241 1581 W2341535066.pdf 5 12 separator 0.93496335 ¶ 1581 1583 W2341535066.pdf 5 13 text 0.99887925 "(iv) When the share of PV covering the current energy demand exceeds 11-12% (55–60GWp of installedcapacity), greater and greater energy surpluses starttooccur.Forexample,wheninstalledcapacityreaches97.5GWp then 39% of generated energy is perceivedas a surplus and must be stored or exported, notmentioning the fact that in the same time otherenergysourcesarenotgeneratingenergyatall." 1583 1969 W2341535066.pdf 5 14 separator 0.99331105 ¶ 1969 1971 W2341535066.pdf 5 15 title 0.65016234 (v) Energy generation 1971 1993 W2341535066.pdf 5 16 text 0.5000532 from 1993 1998 W2341535066.pdf 5 17 title 0.614362 photovoltaic installations 1998 2025 W2341535066.pdf 5 18 separator 0.822696 ¶ 2025 2027 W2341535066.pdf 5 19 text 0.99954134 "does not lead to a decrease in maximal energyd e m a n d .Th i si sd u et ot h ef a c tt h a tp e a ke n e r g y demand in Poland occurs after sunset. However,an increasing energy consumption resulting fromgreater demand for air-conditioning may be effec-tively covered from PV, especially BIPV (BuildingIntegratedPhotovoltaics)[23]." 2027 2363 W2341535066.pdf 5 20 separator 0.9878217 ¶ 2363 2365 W2341535066.pdf 5 21 text 0.9995476 "Overall, similarly as in the paper presented by De Jong et al. [9], a correlation between irradiation values andenergy demand curve has been found. Obtained results arec o h e r e n to nt h ef a c tt h a tP Vh a sp o t e n t i a lt oc o n t r i b u t et othe energy generation during morning and early afternoonhours. However, presented in Figures 5 and 6, irradiationprofiles are idealized, meaning they are based on averagedvalues of irradiation. Therefore, one should not expect suchsmooth curves of energy from photovoltaics on a day-to-day basis. According to Lorenz et al. [24], one solution isto employ regional PV energy generation forecasts to bettermanageenergyproductionfromconventionalpowerunits." 2365 3076 W2341535066.pdf 5 22 separator 0.9963422 ¶ 3076 3078 W2341535066.pdf 5 23 title 0.9894936 5. Conclusions 3078 3093 W2341535066.pdf 5 24 separator 0.9962617 ¶ 3093 3095 W2341535066.pdf 5 25 text 0.9996834 "This study concludes that photovoltaics have huge potentialto contribute to covering energy demand in Poland. Addi-tionally, conducted analysis has shown that there are some boundaries which should not be crossed when it comes to the maximal capacity installed in PV plants in Poland(however,currenttrendsshowthatexceedingeven1GWpintheimmediatefutureisratherunlikely).Thisstudyunveiledseveral interesting directions for future research. First ofall, there is a need to perform the thorough analysis of airconditionersimpactonpowerdemandandhowitcorrelateswithirradiationvalues.Secondly,amoredetailedanalysisofregionalenergydemandpatternsisessentialtocreateamodelwhich will aim at optimally distributing variable energysources whilst taking into the consideration limited capaci-ties of transmissions networks. Finally, a regional potentialfor energy storage in form of pumped-storage or run-of-river power plants with pondage coupled with photovoltaicsshouldbeinvestigatedandestimated." 3095 4084 W2341535066.pdf 5 26 separator 0.996841 ¶ 4084 4086 W2341535066.pdf 5 27 title 0.9903433 Competing Interests 4086 4106 W2341535066.pdf 5 28 separator 0.9945555 ¶ 4106 4108 W2341535066.pdf 5 29 text 0.995881 Theauthorsdeclarethattheyhavenocompetinginterests. 4108 4159 W2341535066.pdf 5 30 separator 0.9955855 ¶ 4159 4161 W2341535066.pdf 5 31 title 0.9596711 References 4161 4172 W2341535066.pdf 5 32 separator 0.99049616 ¶ 4172 4174 W2341535066.pdf 5 33 bibliography 0.9917039 "[1]Statistics on Electrical Power Engineering in Poland ,E n e r g y MarketAgency,Warszawa,Poland,2013." 4174 4280 W2341535066.pdf 5 34 separator 0.5958314 ¶ 4280 4282 W2341535066.pdf 5 35 bibliography 0.99651355 "[2] M.A.EltawilandZ.Zhao,“Grid-connectedphotovoltaicpower systems:technicalandpotentialproblems—areview,” Renewable andSustainableEnergyReviews ,vol.14,no .1,pp .112–129 ,2010." 4282 4463 W2341535066.pdf 5 36 separator 0.8670755 ¶ 4463 4465 W2341535066.pdf 5 37 bibliography 0.99185467 "[3] EnergyRegulatoryAuthority,http://www.ure.gov.pl/uremapoze/ mapa.html." 4465 4541 W2341535066.pdf 5 38 separator 0.83595717 ¶ 4541 4543 W2341535066.pdf 5 39 bibliography 0.99625224 "[4] L.E.Jones, RenewableEnergyIntegration:PracticalManagement of Variability, Uncertainty, and Flexibility in Power Grids ,A c a - demicPress,2014." 4543 4695 W2341535066.pdf 5 40 separator 0.8758315 ¶ 4695 4697 W2341535066.pdf 5 41 bibliography 0.99571323 "[5] B. Burger, Stromerzeugung aus Solar- und Windenergie im Jahr 2015,Fraunhofer-Institutf ̈ursolareEnergiesystemeISE,2016." 4697 4823 W2341535066.pdf 5 0 paratext 0.98915875 200 Heng Xie 0 12 W2188137521.pdf 5 1 separator 0.9952135 ¶ 12 14 W2188137521.pdf 5 2 text 0.99502265 "Proof.We may use Wi(X,L)∗to simplify the notation Wi(X∗,L∗). We wish to prove the Witt theory case by induction on cells. Firstly, note tha t the pullback maps Wi(A)→Wi(An A) andWi(B)→Wi(An B) are isomorphisms by homotopy invariance, cf. Theorem 3.1 [4]. It follows that Wi(An A)∼=Wi(An B)." 14 321 W2188137521.pdf 5 3 separator 0.96693456 ¶ 321 323 W2188137521.pdf 5 4 text 0.84290874 "LetX=Z0⊃Z1⊃ ··· ⊃ZN=∅be the filtration such that Zk−1−Zk∼=Ank=:Ck." 323 391 W2188137521.pdf 5 5 separator 0.7782865 ¶ 391 393 W2188137521.pdf 5 6 text 0.986529 "In general, the closed subvarieties Zkmay not be smooth. However, let Uk be the open subvariety X−Zkfor each 0 ≤k≤N. EveryUkis smooth inX. There is another filtration X=UN⊃UN−1⊃ ··· ⊃U0=∅with Uk−Uk−1=Zk−1−Zk∼=Ckclosed inUkof codimension dk. Consider the following commutative diagram of localization sequences." 393 711 W2188137521.pdf 5 7 separator 0.993458 ¶ 711 713 W2188137521.pdf 5 8 math 0.8357971 "Wi−1(Uk−1)A−→Wi Ck(Uk,L)A−→Wi(Uk,L)A−→Wi(Uk−1)A−→Wi+1 Ck(Uk,L)A /arrowbt/arrowbt/arrowbt/arrowbt/arrowbt Wi−1(Uk−1)B−→Wi Ck(Uk,L)B−→Wi(Uk,L)B−→Wi(Uk−1)B−→Wi+1 Ck(Uk,L)B" 713 904 W2188137521.pdf 5 9 separator 0.9474766 ¶ 904 906 W2188137521.pdf 5 10 text 0.9949589 "Here,Wi Ck(Uk,L) means the L-twistedith-Witt group of Ukwith supports on Ck. Note that any line bundle over ( Ck)Ais trivial, since Pic(An A)∼=Pic(A) = 0 (Ais regular local and so it is a UFD)." 906 1108 W2188137521.pdf 5 11 separator 0.9019265 ¶ 1108 1110 W2188137521.pdf 5 12 text 0.9302105 "By the d ́ evissage theorem (cf. [10]), we deduce that Wi Ck(Uk,L)A∼=Wi Ck(Uk,L)Bfor alli. Moreover, by induction hypothesis, Wi(Uk−1)A∼=Wi(Uk−1)Bfor alli. Applyingthe5-lemma,oneseesthatthemiddleverticalmapisanisomo rphism. Since theK-theory analog of this theorem is also true by induction on cells, theGW-theory cases follow by Karoubi induction, cf. Section 3 [6]." 1110 1493 W2188137521.pdf 5 13 separator 0.9965577 ¶ 1493 1495 W2188137521.pdf 5 14 title 0.9861945 Corollary 4.1.The Witt group (resp. the Grothendieck-Witt group) 1495 1560 W2188137521.pdf 5 15 separator 0.99431837 ¶ 1560 1562 W2188137521.pdf 5 16 text 0.85995865 "Wi(X,L)K(resp.GWi(X,L)K) is isomorphic to Wi(X,L)C(resp.GWi(X,L)C) for eachiand any line bundle LoverX." 1562 1672 W2188137521.pdf 5 17 separator 0.9910685 ¶ 1672 1674 W2188137521.pdf 5 18 paratext 0.9878713 Documenta Mathematica 19 (2014) 195–208 1674 1714 W2188137521.pdf 5 0 paratext 0.6461714 Rare snake eel from Saipan and Japan 217 0 40 W4295837928.pdf 4 1 separator 0.9882405 ¶ 40 42 W4295837928.pdf 4 2 bibliography 0.9976811 "Karrer, C. 1983. Anguilliformes du Canal de Mozambique (Pisces, Tele- ostei). Faune Tropicale 23: 1–116." 42 149 W4295837928.pdf 4 3 separator 0.9799391 ¶ 149 151 W4295837928.pdf 4 4 bibliography 0.9978269 "McCosker, J. E. 1977. The osteology, classification, and relationships of the eel family Ophichthidae. Proceedings of the California Acad- emy of Sciences (Series 4) 41: 1–123." 151 333 W4295837928.pdf 4 5 separator 0.98045444 ¶ 333 335 W4295837928.pdf 4 6 bibliography 0.9976666 "McCosker, J. E. 1999. Pisces Anguilliformes: deepwater snake eels (Ophichthidae) from the New Caledonia region, southwest Pacific Ocean. Mémoires du Muséum National d’Histoire Naturelle 180: 571–588." 335 538 W4295837928.pdf 4 7 separator 0.9841039 ¶ 538 540 W4295837928.pdf 4 8 bibliography 0.9975199 "McCosker, J. E. 2005. A new species of deepwater snake eel, Ophichthus pullus (Anguilliformes: Ophichthidae) from Angola and Guinea- Bissau. Proceedings of the California Academy of Sciences (Series 4) 56: 669–674." 540 761 W4295837928.pdf 4 9 separator 0.9840435 ¶ 761 763 W4295837928.pdf 4 10 bibliography 0.9972686 "McCosker, J. E. 2010. Deepwater Indo-Pacific species of the snake-eel genus Ophichthus (Anguilliformes: Ophichthidae), with the de- scription of nine new species. Zootaxa 2505: 1–39." 763 952 W4295837928.pdf 4 11 separator 0.9864995 ¶ 952 954 W4295837928.pdf 4 12 bibliography 0.9976691 "McCosker, J. E., Böhlke, E. B., and Böhlke, J. E. 1989. Family Ophich-thidae. Pp. 254–412. In : Böhlke, E. B. (Ed.) Fishes of the Western North Atlantic, Part 9, Vol. 1: Orders Anguilliformes and Sacco-pharyngiformes. Sears Foundation for Marine Research, Y ale Uni- versity, New Haven." 954 1247 W4295837928.pdf 4 13 separator 0.9873868 ¶ 1247 1249 W4295837928.pdf 4 14 bibliography 0.9971005 "McCosker, J. E. and Ho, H.-C. 2015. New species of the snake eels Ech - elus and Ophichthus (Anguilliformes: Ophichthidae) from Taiwan. Zootaxa 4060: 71–85." 1249 1412 W4295837928.pdf 4 15 separator 0.9843241 ¶ 1412 1414 W4295837928.pdf 4 16 bibliography 0.9979394 "McCosker, J. E., Ide, S., and Endo, H. 2012. Three new species of ophichthid eels (Anguilliformes: Ophichthidae) from Japan. Bul-letin of the National Museum of Nature and Science, Series A, Supplement 6: 1–16." 1414 1628 W4295837928.pdf 4 17 separator 0.98375225 ¶ 1628 1630 W4295837928.pdf 4 18 bibliography 0.997207 "Sabaj, M. H. 2016. Standard symbolic codes for institutional resource collections in herpetology and ichthyology: an Online Reference. Version 6.5 (16 August 2016). American Society of Ichthyologists and Herpetologists, Washington DC. Available at http://www.asih.org/ (16 February 2017)." 1630 1922 W4295837928.pdf 4 0 paratext 0.9868769 Appl. Sci. 2020 ,10, 2155 8 of 8 0 32 W3014075112.pdf 7 1 separator 0.99051434 ¶ 32 34 W3014075112.pdf 7 2 bibliography 0.9980598 "4. Villa, F.A.; Markovic, B.; Bellisai, S.; Bronzi, D.; Tosi, A.; Zappa, F.; Tisa, S.; Durini, D.; Weyers, S.; Paschen, U.; et al. SPAD smart pixel for time-of-flight and time-correlated single-photon counting measurements. IEEE Photonics J. 2012 ,4, 795–804. [CrossRef]" 34 308 W3014075112.pdf 7 3 separator 0.9366254 ¶ 308 310 W3014075112.pdf 7 4 bibliography 0.99814844 "5. Bruschini, C.; Homulle, H.; Antolovic, I.M.; Burri, S.; Charbon, E. Single-photon avalanche diode imagers in biophotonics: Review and outlook. Light. Sci. Appl. 2019 ,8, 87. [CrossRef] [PubMed]" 310 509 W3014075112.pdf 7 5 separator 0.93082726 ¶ 509 511 W3014075112.pdf 7 6 bibliography 0.99813527 "6. Cova, S.; Ghioni, M.; Lacaita, A.L.; Samori, C.; Zappa, F. Avalanche photodiodes and quenching circuits for single-photon detection. Appl. Opt. 1996 ,35, 1956–1976. [CrossRef] [PubMed]" 511 701 W3014075112.pdf 7 7 separator 0.9166628 ¶ 701 703 W3014075112.pdf 7 8 bibliography 0.99812716 "7. Niclass, C.; Gersbach, M.; Henderson, R.; Grant, L.; Charbon, E. A single photon avalanche diode implemented in 130-nm CMOS technology. IEEE J. Sel. Top. Quantum Electron. 2007 ,13, 863–869. [CrossRef]" 703 910 W3014075112.pdf 7 9 separator 0.92615664 ¶ 910 912 W3014075112.pdf 7 10 bibliography 0.9978275 "8. Takai, I.; Matsubara, H.; Soga, M.; Ohta, M.; Ogawa, M.; Yamashita, T. Single-Photon avalanche diode with enhanced NIR-sensitivity for automotive LIDAR systems. Sensors (Switzerland) 2016 ,16, 459. [CrossRef] [PubMed]" 912 1137 W3014075112.pdf 7 11 separator 0.9644062 ¶ 1137 1139 W3014075112.pdf 7 12 bibliography 0.99806166 "9. Murtaza, S.; Anselm, K.; Hu, C.; Nie, H.; Streetman, B.; Campbell, J. Resonant-cavity enhanced (RCE) separate absorption and multiplication (SAM) avalanche photodetector (APD). IEEE Photonics Technol. Lett. 1995 ,7, 1486–1488. [CrossRef]" 1139 1384 W3014075112.pdf 7 13 separator 0.9488418 ¶ 1384 1386 W3014075112.pdf 7 14 bibliography 0.9980154 "10. Boulanger, S.; Ingelberts, H.; Dries, T.V .D.; Gasser, A.; Kuijk, M. A novel 350 nm CMOS optical receiver based on a current-assisted photodiode detector. In Proceedings of the Silicon Photonics XIV , San Francisco, CA, USA, 4–6 February 2019; p. 51." 1386 1645 W3014075112.pdf 7 15 separator 0.9659726 ¶ 1645 1647 W3014075112.pdf 7 16 bibliography 0.9979961 "11. van Nieuwenhove, D.; van der Tempel, W.; Kuijk, M. Novel standard CMOS detector using majority current for guiding photo-generated electrons towards detecting junctions. In Proceedings of the Symposium IEEE/LEOS Benelux, Mons, Belgium, 1–2 December 2005; pp. 229–232." 1647 1923 W3014075112.pdf 7 17 separator 0.9680822 ¶ 1923 1925 W3014075112.pdf 7 18 bibliography 0.99808776 "12. Kato, Y.; Sano, T.; Moriyama, Y.; Maede, S.; Yamazaki, T.; Nose, A.; Shina, K.; Yasu, Y.; van der Tempel, W.; Ercan, A.; et al. 320 240 Back-Illuminated 10- m CAPD Pixels for High-Speed Modulation Time-of-Flight {CMOS} Image Sensor. IEEE J. Solid State Circuits 2018 ,53, 1071–1078. [CrossRef]" 1925 2229 W3014075112.pdf 7 19 separator 0.9483561 ¶ 2229 2231 W3014075112.pdf 7 20 bibliography 0.9977581 "13. Ingelberts, H.; Kuijk, M. High-speed gated CMOS detector for fluorescence lifetime microscopy extending to near-infrared wavelengths. In Proceedings of the 2015 IEEE SENSORS, Busan, Korea, 1–4 November 2015; pp. 1–4." 2231 2455 W3014075112.pdf 7 21 separator 0.9646978 ¶ 2455 2457 W3014075112.pdf 7 22 bibliography 0.99792385 "14. Jegannathan, G.; Ingelberts, H.; Boulanger, S.; Kuijk, M. Current assisted avalanche photo diodes (CAAPDs) with separate absorption and multiplication region in conventional CMOS. Appl. Phys. Lett. 2019 ,115, 132101. [CrossRef]" 2457 2693 W3014075112.pdf 7 23 separator 0.9529711 ¶ 2693 2695 W3014075112.pdf 7 24 bibliography 0.9977747 "15. Fishburn, M. Fundamentals of CMOS Single-Photon Avalanche Diodes ; Technische Universiteit Delft: Delft, The Netherlands, 2012." 2695 2829 W3014075112.pdf 7 25 separator 0.9363886 ¶ 2829 2831 W3014075112.pdf 7 26 bibliography 0.99792033 "16. Giudice, A.; Ghioni, M.; Cova, S.; Zappa, F. A process and deep level evaluation tool: Afterpulsing in avalanche junctions. In Proceedings of the ESSDERC’03, 33rd Conference on European Solid-State Device Research, Estoril, Portugal, 16–18 September 2003; pp. 347–350." 2831 3108 W3014075112.pdf 7 27 separator 0.95855796 ¶ 3108 3110 W3014075112.pdf 7 28 bibliography 0.9978271 "17. Basavanagoud, C.; Bhat, K. E ect of Lateral Curvature on the Breakdown Voltage of Planar Diodes. IEEE Electron Device Lett. 1985 ,6, 276–278. [CrossRef]" 3110 3270 W3014075112.pdf 7 29 separator 0.9156312 ¶ 3270 3272 W3014075112.pdf 7 30 bibliography 0.9978925 "18. Speeney, D.; Carey, G. Experimental study of the e ect of junction curvature on breakdown voltage in Si. Solid State Electron. 1967 ,10, 177–182. [CrossRef]" 3272 3436 W3014075112.pdf 7 31 separator 0.94494355 ¶ 3436 3438 W3014075112.pdf 7 32 bibliography 0.9980031 "19. Bronzi, D.; Villa, F.A.; Tisa, S.; Tosi, A.; Zappa, F. SPAD Figures of Merit for Photon-Counting, Photon-Timing, and Imaging Applications: A Review. IEEE Sensors J. 2015 ,16, 3–12. [CrossRef]" 3438 3636 W3014075112.pdf 7 33 separator 0.93993187 ¶ 3636 3638 W3014075112.pdf 7 34 bibliography 0.9976986 "20. Villa, F.A.; Bronzi, D.; Zou, Y.; Scarcella, C.; Boso, G.; Tisa, S.; Tosi, A.; Zappa, F.; Durini, D.; Weyers, S.; et al. CMOS SPADs with up to 500 m diameter and 55% detection e ciency at 420 nm. J. Mod. Opt. 2014 ,61, 102–115. [CrossRef]" 3638 3886 W3014075112.pdf 7 35 separator 0.96089256 ¶ 3886 3888 W3014075112.pdf 7 36 bibliography 0.9977831 "21. Niclass, C.; Sergio, M.; Charbon, E. A single photon avalanche diode array fabricated in 0.35- m CMOS and based on an event-driven readout for TCSPC experiments. In Proceedings of the SPIE 6372, Advanced Photon Counting Techniques, Boston, MA, USA, 3 November 2006." 3888 4163 W3014075112.pdf 7 37 separator 0.9634472 ¶ 4163 4165 W3014075112.pdf 7 38 bibliography 0.9978127 "22. Tisa, S.; Guerrieri, F.; Zappa, F. Variable-load quenching circuit for single-photon avalanche diodes. Opt. Express 2008 ,16, 2232–2244. [CrossRef] [PubMed]" 4165 4328 W3014075112.pdf 7 39 separator 0.89058566 ¶ 4328 4330 W3014075112.pdf 7 40 paratext 0.9775531 "©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http: //creativecommons.org /licenses /by/4.0/)." 4330 4575 W3014075112.pdf 7 0 text 0.99782306 "control also opens the way to integrating long-lived nuclear spins in hybrid quantum architectures in which mechanics isused as a quantum bus linking different types of qubits[16–18]." 0 185 W4220704281.pdf 2 1 separator 0.99564964 ¶ 185 187 W4220704281.pdf 2 2 title 0.9907247 II. RESULTS 187 199 W4220704281.pdf 2 3 separator 0.99598956 ¶ 199 201 W4220704281.pdf 2 4 text 0.9995931 "In our experiments, the interaction between the nuclear spin and mechanical vibrations is mediated by a single,negatively charged, silicon-vacancy center (SiV). The mechanical vibrations are surface acoustic waves (SAWs), which have natural two-dimensional confinement, can beguided on chip and are easily generated by electricalexcitation of interdigital transducers (IDTs) [29]. We pattern aluminium IDTs on top of a layer of piezoelectric aluminium nitride deposited on the surface of a single-crystal diamond.The diamond sample is ultrapure (nitrogen concentration less than 5 ppb) and has a natural abundance of the 13Ci s o t o p e (1.1%). The diamond is implanted with28Siþions and annealed to form SiV centers, which can be opticallyaddressed individually. The SiVs are located within the strain field of the SAW, which extends about a wavelength (about 3μm) below the surface of the diamond [Fig. 1(a)]. The sample is cooled to below 200 mK in a dilution refrigerator to increase the lifetime of the SiVelectron spin ( S1⁄41=2)[30]." 201 1267 W4220704281.pdf 2 5 separator 0.9833851 ¶ 1267 1269 W4220704281.pdf 2 6 text 0.9995756 "An external magnetic field of 0.13 T at an angle of 90° withrespect to the SiVaxis lifts the spin degeneracy and introducesa splitting of f ↓↑1⁄43.42GHz between the j↓iandj↑ispin states [Fig. 1(b)]. The field angle of 90° is chosen to maximize the strain susceptibility of the SiV spin [31].T h eo p t i c a l transition labeled ↓↓0can be excited resonantly by laser pulses to initialize the SiV in j↑ivia optical pumping, while the↓↑transition can be driven acoustically to coherently transfer population between j↓iandj↑i[29]." 1269 1810 W4220704281.pdf 2 7 separator 0.9837333 ¶ 1810 1812 W4220704281.pdf 2 8 text 0.9957654 "The mechanical coupling to the13C nuclear spin (S1⁄41=2) relies on the simultaneous coupling of a SiV electronic spin to acoustic waves and to the nuclear spin. An individual13C nuclear spin couples to a SiV spin via the hyperfine interaction Hamiltonian H1⁄42πħSSiVzðAkSnuczþA⊥SnucxÞ; where Si1⁄4σi=2are the spin operators, with σibeing the Pauli matrices for i∈fx; y; z g(“SiV”and “nuc”indicate SiV and nuclear spins, respectively), and AkandA⊥are the parallel and perpendicular components of the hyperfine coupling. This coupling causes the nuclear spin to precess about slightly different axes depending on the state of the SiV spin. This can be utilized to control the nuclear spin state[4,27,32] with the basic sequence depicted in Fig. 1(c). After the SiV spin is initialized in j↑i, a series of periodically timed acoustic pulses (with interpulse delay τ) flip its state repeatedly, causing the nuclear spin to alternate betweentwo different precession axes. If the acoustic pulses are synchronized with the precession of the nuclear spin, such that[4,12]τ" 1812 2905 W4220704281.pdf 2 9 math 0.86657816 "≈ 2kþ1 4fL/C20 1−A2 ⊥ 8f2 L/C21 ¶" 2905 2950 W4220704281.pdf 2 10 text 0.9643074 "; for integer values of k, where fLis the nuclear Larmor frequency, the nuclear spin rotates on the Bloch sphere by an angle φ, around an effective axis n. The angle φis determined" 2950 3137 W4220704281.pdf 2 11 separator 0.80762506 ¶ 3137 3139 W4220704281.pdf 2 12 table 0.845838 "(a) AlN Diamond13C SiVTraveling acoustic waveProbe laser Hyperfine interaction (b) Optical ( Acoustic ( ) Optical ( Acoustic ( )Init x8(c)) )(d)" 3139 3306 W4220704281.pdf 2 13 math 0.51252085 ¶ 3306 3308 W4220704281.pdf 2 14 table 0.52248204 π 3308 3310 W4220704281.pdf 2 15 separator 0.99208367 ¶ 3310 3312 W4220704281.pdf 2 16 caption 0.9895678 FIG. 1. Principle behind mechanical coupling to nuclear spins. 3312 3375 W4220704281.pdf 2 17 separator 0.9903033 ¶ 3375 3377 W4220704281.pdf 2 18 text 0.7387639 (a) Schematic of the 3377 3398 W4220704281.pdf 2 19 caption 0.5079397 system 3398 3405 W4220704281.pdf 2 20 text 0.7028913 . Surface acoustic waves (SAWs) 3405 3436 W4220704281.pdf 2 21 caption 0.64192986 generated 3436 3445 W4220704281.pdf 2 22 text 0.6403201 in the AlN layer, and extending into diamond 3445 3490 W4220704281.pdf 2 23 caption 0.5851317 ", are usedto control the 13C nuclear spin via its" 3490 3541 W4220704281.pdf 2 24 text 0.5024979 hyperfine 3541 3551 W4220704281.pdf 2 25 caption 0.5500916 coupling to the 3551 3567 W4220704281.pdf 2 26 text 0.85413367 "¶ silicon vacancy (SiV) electron spin, which can be initialized andread out optically. (b) Simplified electronic structure of the SiV inthe presence of an external magnetic field. The red arrows (bothdashed and solid) indicate optical transitions around 737 nm. Thesolid red arrow corresponds to the transition ð↓↓ 0Þused for optical pumping to initialize the SiV state in j↑i. The blue arrow corresponds to the 3.42-GHz spin-flipping transition ↓↑that can be driven acoustically. (c) Schematic of a sequence that" 3567 4089 W4220704281.pdf 2 27 caption 0.48977292 induc 4089 4095 W4220704281.pdf 2 28 text 0.92226255 "esconditional precession of the nuclear spin. The optical partcorresponds to the optical initialization of the SiV spin intoj↑i. The SiV spin can be initialized in j↓iby exciting the ↑↑ 0 transition. The acoustic part corresponds to a series of eight, periodically timed, acoustic πpulses around the Xaxis of the Bloch sphere ( Rπx). (" 4095 4438 W4220704281.pdf 2 29 caption 0.7383117 d 4438 4439 W4220704281.pdf 2 30 text 0.5839129 ) 4439 4440 W4220704281.pdf 2 31 caption 0.90206313 "Simulation of the evolution of the nuclear spin on the Bloch sphere for the sequence described in diagram(c). The red (blue) arrow correspond" 4440 4584 W4220704281.pdf 2 32 text 0.5827351 s to the nuclear spin 4584 4605 W4220704281.pdf 2 33 caption 0.7030307 pre 4605 4608 W4220704281.pdf 2 34 text 0.54922503 cession 4608 4615 W4220704281.pdf 2 35 caption 0.5902166 axis 4615 4621 W4220704281.pdf 2 36 text 0.9723 "when the SiV is in j↑i(j↓i). The nuclear spin starts in j↓i nucand follows the red (blue) trajectory when the SiV is initially in j↑i(j↓i). Spin flips of the SiV are indicated by transitions between solid and dashed trajectories. The red (blue)dot indicates the final state of the nuclear spin for the SiV initiallyin state j↑i(j↓i). The hyperfine coupling parameters used are fA k1⁄40.11MHz ;A⊥1⁄40.33MHz g, and the interpulse time is τ1⁄40.169μs." 4621 5077 W4220704281.pdf 2 37 paratext 0.97547644 SMARAK MAITY et al. PHYS. REV . X 12,011056 (2022) 5077 5127 W4220704281.pdf 2 38 separator 0.70862997 5127 5128 W4220704281.pdf 2 39 paratext 0.87052065 ¶ 011056-2 5128 5138 W4220704281.pdf 2 0 paratext 0.8321643 Speed of sound in liquid difluoromethane 69 0 43 W2055273716.pdf 14 1 separator 0.99283475 ¶ 43 45 W2055273716.pdf 14 2 bibliography 0.99788016 "12. Grebenkov, A. J.; Zhelezny, V. P.; Klepatsky, P. M.; Beljaeva, O. V.; Chernjak, Yu.A.; Kotelevsky, Yu.G.; Timofeev, B. D. Int.J.Thermophysics 1996, 17, 535 ]549." 45 213 W2055273716.pdf 14 3 separator 0.9554147 ¶ 213 215 W2055273716.pdf 14 4 bibliography 0.99778837 "13. Beljaeva, O. V.; Grebenkov, A.J.; Zajatz, T. A.; Timofeev, B. D. Bull.of the Acad .of Sciences of Belarus ,Phys.-Tech .Science 1995, 39, 108 ]111." 215 368 W2055273716.pdf 14 5 separator 0.9497174 ¶ 368 370 W2055273716.pdf 14 6 bibliography 0.99794644 14. Papadakis, E. P. The Journal of The Acoustical Society of America 1967, 42, 1045 ]1051. 370 462 W2055273716.pdf 14 7 separator 0.9101224 ¶ 462 464 W2055273716.pdf 14 8 bibliography 0.9978601 15. Guedes, H. J. R.; Zollweg, J. A. Int.J.Refrig .1992, 15, 381 ]385. 464 535 W2055273716.pdf 14 9 separator 0.88143003 ¶ 535 537 W2055273716.pdf 14 10 bibliography 0.99793565 16. Muringer, M. J. P.; Trappeniers, N. J.; Biswas, S. N. Phys. Chem .Liq.1985, 14, 273 ]296. 537 631 W2055273716.pdf 14 11 separator 0.9289335 ¶ 631 633 W2055273716.pdf 14 12 bibliography 0.9957579 "17. Nieto de Castro, C. A.; Santos, F. J. V.; Mardolcar, U. V. 19th International Congress of Refrigeration , . The Hague, The Netherlands, International Institute of Refrigeration IIRrIIF . 1995, IVa, pp. 436 ]441." 633 854 W2055273716.pdf 14 13 separator 0.9536598 ¶ 854 856 W2055273716.pdf 14 14 bibliography 0.9977517 18. Magee, J. W. Int.J.Thermophys. 1996, 17, 803 ]822. 856 911 W2055273716.pdf 14 15 separator 0.9514121 ¶ 911 913 W2055273716.pdf 14 16 bibliography 0.99728525 "19. Sifner, O. Abstracts of the 13th Symposium on Thermophysical Properties , Boulder, Colorado, U.S.A. 1997, p. 332." 913 1033 W2055273716.pdf 14 17 separator 0.96173793 ¶ 1033 1035 W2055273716.pdf 14 18 bibliography 0.9979388 "20. Craven, R. J. B.; Kilner, J.; Wakeham, W. A. Abstracts of the 13rd Symposium on Thermophysical Properties , Boulder, Colorado, U.S.A. 1997, p. 228." 1035 1189 W2055273716.pdf 14 19 separator 0.98978853 ¶ 1189 1191 W2055273716.pdf 14 20 paratext 0.9229839 ()Recei ̈ed 2 February 1998; in final form 21 July 1998 1191 1247 W2055273716.pdf 14 21 separator 0.9681777 ¶ 1247 1249 W2055273716.pdf 14 22 paratext 0.92963886 WA98r006 1249 1258 W2055273716.pdf 14 0 paratext 0.97875595 "7 Vol.:(0123456789) Scientific Reports | (2022) 12:18744 | https://doi.org/10.1038/s41598-022-21719-x" 0 112 W4308246107.pdf 6 1 separator 0.90013105 ¶ 112 114 W4308246107.pdf 6 2 text 0.53174424 www.nature.com 114 129 W4308246107.pdf 6 3 paratext 0.48405007 / 129 130 W4308246107.pdf 6 4 text 0.4612167 scientific 130 140 W4308246107.pdf 6 5 paratext 0.48066285 reports/classifier 140 158 W4308246107.pdf 6 6 text 0.43817082 s 158 159 W4308246107.pdf 6 7 paratext 0.44718227 . If replicated, these 159 181 W4308246107.pdf 6 8 text 0.42443538 results 181 189 W4308246107.pdf 6 9 paratext 0.3978149 may benefit 189 201 W4308246107.pdf 6 10 text 0.42918807 the 201 205 W4308246107.pdf 6 11 paratext 0.38544646 development 205 217 W4308246107.pdf 6 12 text 0.41909373 of 217 220 W4308246107.pdf 6 13 paratext 0.45248702 novel 220 226 W4308246107.pdf 6 14 text 0.35054776 prac 226 231 W4308246107.pdf 6 15 paratext 0.37905216 titioner 231 239 W4308246107.pdf 6 16 text 0.42347163 - 239 240 W4308246107.pdf 6 17 paratext 0.3668059 oriented training 240 257 W4308246107.pdf 6 18 text 0.9922094 "tools to detect ASD (vs. other conditions) more efficiently and/or optimize the screening, triaging and diagnosing of those individuals seen in specialized institutions by aiding clinical experts particularly in the challenging process of differential diagnosis. Notably, individuals who are referred to ASD outpatient clinics are usually not evaluated for ADHD as part of the assessment routine due to numerous pragmatic considerations (e.g., personnel and financial resources, or time constraints of patients and their families). Thus, one could contemplate the feasibility of developing some kind of ADHD screening score based the behavioral classifiers from ADOS/ADI-R that best separated ADHD from the other groups. This could guide the decision-making process of whether an additional evaluation for ADHD is clinically justified or not." 257 1124 W4308246107.pdf 6 19 separator 0.9953728 ¶ 1124 1126 W4308246107.pdf 6 20 title 0.97811127 Methods 1126 1134 W4308246107.pdf 6 21 separator 0.99600494 ¶ 1134 1136 W4308246107.pdf 6 22 text 0.9995529 "Sample. The sample was derived from Germany’s largest database of individuals referred to special- ized ASD outpatient clinics51. The whole database includes 2453 individuals (16.8% female; age: 1–72 years, M = 13.56 ± 10.61) of whom 1260 (51.4%) were diagnosed with ASD, others had another mental condition (n = 844; 34.4%; e.g., ADHD, mood or anxiety disorders), and 349 (14.2%) did not receive any psychiatric diag- nosis. All individuals were diagnosed according to the International Classification of Diseases ICD-1052 using “gold standard” best estimate clinical (BEC) diagnoses53. Any BEC diagnosis was determined by at least two experienced clinicians from a multidisciplinary team (incl. psychologists and/or psychiatrists) after extensive examination and review of all available information from a patient’s medical record that included—amongst oth- ers—IQ test results, the Autism Diagnostic Observation Schedule (ADOS16, the Autism Diagnostic Interview- Revised (ADI-R17, and a differential/co-occurring diagnoses algorithm performed by an experienced psychia- trist. ADOS and ADI-R were conducted by clinically trained team members at each center who were all licensed to do so. The study was approved by the ethics committee of the Philipps-University Marburg (Az. 92/20). Due to the retrospective nature of our data collection and analysis, the need for informed consent was waived by the ethics committee. All methods were performed in accordance with the relevant guidelines and regulations." 1136 2683 W4308246107.pdf 6 23 separator 0.98446304 ¶ 2683 2685 W4308246107.pdf 6 24 text 0.99950784 "For the purpose of the present study, our sample was selected according to the following criteria: (i) referred for a clinical ASD diagnostic assessment, (ii) complete data of ADOS Module 3 or Module 4, and ADI-R, (iii) verbally fluent, (iv) BEC diagnosis of ASD (F84.0, F84.1, or F84.5) but no ADHD, (v) BEC diagnosis of ADHD (all subtypes F90.0 or F98.8) but no ASD, (vi) co-occurring ASD + ADHD, and (vii) no psychiatric diagnosis (ND). The patients with ASD, ADHD and ASD + ADHD had no other psychiatric diagnoses. With respect to the ADOS, we focused on modules M3 and M4 indicating verbal fluency, because differentiation between ASD and ADHD is especially challenging in verbally fluent patients with average intellectual functioning14,54,55. This resulted in a final sample of n = 1195 individuals (age in years: M = 14.8 ± 9.9, min = 5, max = 72; 14.5% female), including n = 574 individuals with ASD, n = 164 with ADHD, n = 113 with ASD + ADHD, and n = 344 with ND (Table 3). ADOS M3 and M4 data were available from 66.3 and 33.7% of the included participants, respectively." 2685 3808 W4308246107.pdf 6 25 separator 0.8940334 ¶ 3809 3811 W4308246107.pdf 6 26 text 0.99916905 Here, we chose to analyze M3 and M4 data combined in order to be comparable to earlier relevant research14,55. 3811 3923 W4308246107.pdf 6 27 separator 0.95089406 ¶ 3924 3926 W4308246107.pdf 6 28 text 0.99814606 "Please note that the present data are based on the ADOS, but not the more recent ADOS-2 manual56. This is because retrospective data collection spanned across a relatively long time period, dating back to when the Ger - man version of the ADOS-2 was not yet available." 3926 4201 W4308246107.pdf 6 29 separator 0.98802805 ¶ 4201 4203 W4308246107.pdf 6 30 text 0.9979131 "Diagnostic measures and analytic strategy, including machine learning. The current analyses included the item scores of the so-called “gold standard” or best-estimate instruments in diagnosing ASD57: ADOS16,58 and ADI-R59,60. Both are based on ASD criteria of ICD-1052 and DSM-IV-TR61, and they can be used to obtain information about ASD symptoms across different behavioral domains. More details on these two well- established measures can be found in the Supplement." 4203 4686 W4308246107.pdf 6 31 separator 0.9863858 ¶ 4686 4688 W4308246107.pdf 6 32 text 0.9993991 "First, we calculated the proportion of individuals in each of the four groups who met diagnostic algorithm cut-offs in both ADOS and ADI-R, following the analytic procedure analogous to Ref.14. We applied the follow- ing cut-offs for the ADOS/2 (M3: total cut-off spectrum ≥ 8; M4: total cut-off spectrum ≥ 7). According to the ADI-R manual, no total cut-off is to be calculated. However, for the current analysis, we defined the criteria, like Grzadzinski et al.14, that patients who met ASD cut-offs on the three ADI-R domains (“communication” ≥ 10, “social interaction” ≥ 7, “RRB” ≥ 3) reached the ADI-R total cut-off." 4688 5325 W4308246107.pdf 6 33 separator 0.96445453 ¶ 5325 5327 W4308246107.pdf 6 34 text 0.9996325 "We then used support vector machine (SVM) analyses to evaluate which ADOS and ADI-R items are able to discriminate best between ASD (incl. ASD + ADHD) and ADHD, but also between ASD (incl. ASD + ADHD) and ND. SVM is a robust machine learning algorithm, which can be used to examine data for various purposes, such as classification or regression analyses, in order to solve big data classification problems41. SVM is used to find a hyperplane with the maximum margin (i.e., distance between data points from distinct classes) in an n-dimensional space (where n is the number of features) to differentiate between classes62. For instance, SVM has been shown to perform with high accuracy particularly in distinguishing between ASD and ADHD by utiliz- ing only 5 screening items from the SRS39. SVM is the one algorithm that is most frequently used in this line of research likely due to its high predictive power for ASD classification37. According to a recent meta-analysis42, SVM is the most accurate classifier in distinguishing individuals with ASD from those without ASD, ensuring the likelihood that results can be replicated (see43 for a discussion of this issue in the context of the use of ML for ASD diagnostics). SVMs retain several attractive properties: They can deal with noisy, highly correlated features and high-dimensional data sets, and they are resistant to overfitting and thus generalize well41." 5327 6787 W4308246107.pdf 6 35 separator 0.984457 ¶ 6787 6789 W4308246107.pdf 6 36 text 0.99968284 "We adopted a binary classification approach, i.e., we examined pairs of diagnostic groups, resulting in six possible combinations (see Table 2). Our SVM approach for each combination consisted of two steps: First, we ran SVM without feature selection. Second, we applied feature selection to identify the five most relevant ADOS and/or ADI-R features that best discriminated between groups, consistent with recent findings29,31,39. We then" 6789 7240 W4308246107.pdf 6 0 paratext 0.9895246 Nanomaterials 2022 ,12, 1278 8 of 12 0 36 W4224255816.pdf 7 1 separator 0.66817456 ¶ 36 38 W4224255816.pdf 7 2 paratext 0.9806056 Nanomaterials 2022, 12, x FOR PEER REVIEW 8 of 12 38 89 W4224255816.pdf 7 3 separator 0.9887168 ¶ 91 93 W4224255816.pdf 7 4 text 0.99968296 "with ethanol and methanol , presumably due to the formation of hydrogen bonds with the NH2 groups. The response to ammonia was likely due to the interaction between the an- alyte and the residual -COOH moieties present on the NH 2−C2−MWCNTs. A confirmation of this hypothes is came from a sensor realized with a batch of NH 2−C2−MWCNTs having a higher density of NH 2 groups on their surfaces. In this case, we observed an increased response to acetic acid a nd a lower response to ammonia ( Figure S5). All the curves showed similar rise and recovery times, defined as the time to reach 90% and 10% of the peak, respectively, of a few and tens of seconds, thus confirming the same sensing mech- anism for the tested s ubstances." 94 847 W4224255816.pdf 7 5 separator 0.9895968 ¶ ¶ 848 854 W4224255816.pdf 7 6 caption 0.996835 "Figure 8. Test of sensitivity of the network of NH 2−C2−MWCNT based sensor to different chemicals , obtained by exposing the sensor to a saturated cotton swab and showing similar rise and recovery times. The sensor base resistance was 820 Ohm." 854 1107 W4224255816.pdf 7 7 separator 0.99291384 ¶ 1109 1111 W4224255816.pdf 7 8 text 0.99969745 "According to Zaporotskova et al. [29] , the gas molecule adsorption on a single-walled CNT surface result ed in a change in CNT conductivity. The amino group act ed as a charge transfer agent in CNTs , and the number of electrons transferred from the nanotubes to the NH2 molecule increase d [30], thus decreasing the conductivity if the CNTs were an n-type semiconductor , or increasing it in the case of the p-type. In our study, all measurements showed an increase in the resistivity of the MWCNT network when exposed to several volatile substances. Due to the MWCNT wall thickness (>20 nm) , we did not expect that such charge transfer in the proximity of the surface would substantially affect the MWCNTs ’ conductivity." 1111 1866 W4224255816.pdf 7 9 separator 0.9773601 ¶ 1868 1870 W4224255816.pdf 7 10 text 0.9997103 "Because the MWCNTs were 100–200 μm long and quite tangled , as shown in Figure 1, the current in the path between the electrodes passes through many carbon nanotubes, and the device resistance was mostly dominated by the contact resistance between adja- cent MWCNTs. Furthermore, due to the almost compl ete coverage of the MWCNT surface with functional groups (more than 3% atomic N), we expect that the capture of molecules at functionalized surfaces would increase the contact distance between adjacent MWCNTs , generating a resistance increase in the MWCNT network. A similar mechanism in MWCNTs was suggested by Zang et al. [31]. Another possible mechanism involves the formation of S chottky barriers at contacts between CNTs [2 9], assuming a metallic -type conductivity in part of the nanotubes." 1870 2700 W4224255816.pdf 7 11 table 0.9830859 "0 20 40 60 80 100 120 140 160 180 200 2200.981.001.021.041.061.081.101.121.141.16 R/R seconds hexane ethyl ether toluol aceton water vapour methanol ethanol acetic acid ammonia" 2701 2909 W4224255816.pdf 7 12 separator 0.9774394 ¶ 2909 2911 W4224255816.pdf 7 13 caption 0.99276066 Figure 8. Test of sensitivity of the network of NH 2 2911 2964 W4224255816.pdf 7 0 paratext 0.9678172 "IAJPS 2019, 06 (05), 10299 -10304 Imran Khan et al ISSN 2349 -7750 ¶ w w w . i a j p s . c o m Page 10299 CODEN [USA]: IAJPBB ISSN: 2349 -7750 ¶ INDO AMERICAN JOURNAL OF PHARMACEU TICAL SCIENCES ¶ Available online at: http://www.iajps.com Research Article" 0 432 W4288349301.pdf 0 1 separator 0.78837204 ¶ 434 436 W4288349301.pdf 0 2 title 0.98751086 "FREQUENCY OF NASOPHARYNGEAL ANGIOFIBROMA IN PATIENTS PRESENTING WITH RECURRENT EPISTAXIS" 436 528 W4288349301.pdf 0 3 separator 0.9939232 ¶ 530 532 W4288349301.pdf 0 4 contact 0.72635007 "1Dr Imran Khan , 2Dr Muhammad Ibrahim , 3Khalil Ahmad Orakzai , 4Syed Maisam Ali , 5Dr Israr ud Din , 6Dr Inayat Ullah Khan" 532 667 W4288349301.pdf 0 5 separator 0.7290431 ¶ 669 671 W4288349301.pdf 0 6 contact 0.98376524 "1, 5Assistant Professor Ent Department Khyber Teaching Hospital and Medical College Peshawar , 2Assistant Professor Ent Department, Ayub Teaching Hospital and Medical College, Abbottabad , 3Senior Registrar Ent Department, Qazi Hussain Ahmed Teaching Hospital, Nowshehra Medical College Nowshehra , 4Ent Consultant Ent Department Ayub Teaching Hospital, Abbottabad , 6Associate Professor Ent Department, Khyber Teaching Hospital, Peshawar ." 671 1128 W4288349301.pdf 0 7 separator 0.9387326 ¶ 1129 1131 W4288349301.pdf 0 8 paratext 0.98292565 Article Received: March 2019 Accepted: April 2019 Published: May 2019 1131 1223 W4288349301.pdf 0 9 separator 0.98923516 ¶ 1225 1227 W4288349301.pdf 0 10 title 0.89062613 Abstract : 1227 1238 W4288349301.pdf 0 11 separator 0.9758954 ¶ 1239 1241 W4288349301.pdf 0 12 text 0.97668403 Objective : To determine the frequency of nasopharyngeal angiofibroma in patients presenting with recurrent epistaxis . 1241 1364 W4288349301.pdf 0 13 separator 0.85261035 ¶ 1365 1367 W4288349301.pdf 0 14 text 0.918105 Study design : Cross sectional study . 1367 1406 W4288349301.pdf 0 15 separator 0.783432 ¶ 1407 1409 W4288349301.pdf 0 16 text 0.9956036 "Duration and setting : This study was carried out from July 2017 to July 2018 at ENT, Head & Neck Surgery department, Khyber teaching hospital , Peshawar." 1409 1567 W4288349301.pdf 0 17 separator 0.8347347 ¶ 1570 1572 W4288349301.pdf 0 18 text 0.9983728 "Material and method : A total number of 93 patients were included in this study. Patients fulfilling the inclusion criteria were collected from the outdoor patient department (OPD) of ENT, head and neck surgery, Khyber teaching hospital , Peshawar." 1572 1832 W4288349301.pdf 0 19 separator 0.7100692 ¶ 1834 1836 W4288349301.pdf 0 20 text 0.99921423 "Informed consent for participating in the study was taken from all patients. The patients’ biodata along with hospital registration number were entered on proforma. The patients were assessed initially by history and nasal endoscopic. CT sca n nose and PNS with contrast was done and patient admitted and operated for the suspected nasopharyngeal angiofibroma. Biopsy specimen was sent for histopathology to consultant histopathologist in the hospital’s pathology laboratory. Lab reports of th e biopsy specimen showing histopathology of nasopharyngeal angiofibroma were reviewed and data entered in the proforma." 1836 2469 W4288349301.pdf 0 21 separator 0.9846885 ¶ 2472 2474 W4288349301.pdf 0 22 text 0.9996112 "Results : Out of 93 patients, 32% patients were in age range 10 -15 years, 68% patients were in age range 16 -20 years. Mean age was 16 ye ars with SD ± 1.26. Fifty seven percent patients had duration of symptoms <1 year while 43% patients had duration of symptoms > 1 year. The incidence of nasopharyngeal angiofibroma was 18 %. Conclusion : Our study concludes that the incidence of nasopharyng eal angiofibroma in our setup is 18% which can be due to the increasing number of Afg han refugees." 2474 2982 W4288349301.pdf 0 23 separator 0.94174093 ¶ 2984 2986 W4288349301.pdf 0 24 text 0.96838915 Key words : nasopharyngeal angiofibroma, recurrent epistaxis . 2986 3050 W4288349301.pdf 0 25 separator 0.99227345 ¶ 3051 3053 W4288349301.pdf 0 26 contact 0.9867985 "Corresponding author: Dr Imran Khan Assistant Professor Ent Department, Khyber Teaching Hospital and Medical College Peshawar Imranamc@hotmail.com ¶" 3053 3227 W4288349301.pdf 0 27 separator 0.5664978 ¶ 3229 3231 W4288349301.pdf 0 28 paratext 0.744902 Please cite this article in press Imran Khan et al., Frequency of Nasopharyngeal Angiofibroma in Patients 3231 3338 W4288349301.pdf 0 29 separator 0.59672284 ¶ 3339 3341 W4288349301.pdf 0 30 bibliography 0.72728574 Presenting with Recurrent Epistaxis ., Indo Am. J. P. Sci , 3341 3401 W4288349301.pdf 0 31 paratext 0.6452012 2019; 06(05 3401 3413 W4288349301.pdf 0 32 bibliography 0.4801996 3413 3414 W4288349301.pdf 0 33 paratext 0.5276412 ). 3414 3416 W4288349301.pdf 0 34 separator 0.4402889 3417 3418 W4288349301.pdf 0 35 paratext 0.66415864 "¶ QR code" 3418 3432 W4288349301.pdf 0 36 separator 0.87887007 "¶ ¶" 3434 3444 W4288349301.pdf 0 0 table 0.96542096 "Ground truth Generated Absolute error 0.20.4 (a)" 0 64 W4392150056.pdf 44 1 separator 0.97959656 ¶ 64 66 W4392150056.pdf 44 2 table 0.97461617 "Ground truth Generated Absolute error 0.20.4 (b)" 66 131 W4392150056.pdf 44 3 separator 0.9960777 ¶ 131 133 W4392150056.pdf 44 4 caption 0.9959646 Fig. 2.A.2: Test results of EP-Net 2.0 trained on masks with multiple tissue conductivities. Forecast of 21 ms, first frame is an input mask. 133 275 W4392150056.pdf 44 5 separator 0.9940171 ¶ 275 277 W4392150056.pdf 44 6 paratext 0.74112916 28 277 281 W4392150056.pdf 44 7 title 0.8832506 Chapter 2 EP-Net 2.0: Data-Driven Model for Cardiac Electrophysiology Learning 281 359 W4392150056.pdf 44 0 paratext 0.9675074 "International Journal of Medical Science and Clinical Research Studies ISSN(print): 2767 -8326, ISSN(online): 2767 -8342 Volume 0 2 Issue 1 1 November 2022 Page No: 1332 -1335 , Impact Factor: 5.365 37-i11- https://doi.org/10.47191/ijmscrs/v2 DOI: ¶ ¶ 1332 Volume 02 Issue 11 November 2022 Correspond" 0 380 W4309599585.pdf 0 1 contact 0.8204114 ing Author: Jennifer Mendoza Aceves 380 415 W4309599585.pdf 0 2 title 0.96608233 Gastroschisis: Understanding i ts Etiopathogenesis 416 467 W4309599585.pdf 0 3 separator 0.97952974 ¶ ¶ 469 475 W4309599585.pdf 0 4 contact 0.9934847 "Jennifer Mendoza Aceves1, Gabriel Emiliano Martínez Guerrero2, Dora Alicia Can Cabrera3, Jazmin Garcia Cogco4, Sandra M. Rodríguez Flores5" 475 618 W4309599585.pdf 0 5 separator 0.719733 ¶ 619 621 W4309599585.pdf 0 6 contact 0.98765117 "1Universidad de Guadalajara. Guadalajara, Jalisco, México. 2Universidad Villa Rica . Boca del Río, Veracruz, México. 3Universidad Autónoma de Campeche. Campeche, Campeche, México. 4Universidad Veracruzana , Campus Ciudad Mendoza. Veracruz, México. 5Benem érita Universidad Autónoma de Puebla . Puebla de Zarago za, México." 621 960 W4309599585.pdf 0 7 separator 0.98328906 ¶ ¶ 962 968 W4309599585.pdf 0 8 title 0.98479444 ABSTRACT 968 977 W4309599585.pdf 0 9 separator 0.9818104 ¶ ¶ 979 986 W4309599585.pdf 0 10 title 0.9829245 ARTICLE DETAILS 987 1003 W4309599585.pdf 0 11 separator 0.9832489 ¶ ¶ 1003 1009 W4309599585.pdf 0 12 text 0.99965554 "Gastroschisis has been defined as a malformation of the abdominal wall that classically presents as a visceral herniation with the presence of an intact umbilical cord and absence of a membrane covering the abdominal content. Its exact etiology is unknown; however, it is recognized that it presents a multifactorial inheritance pattern. Recently, an increase in the number of cases has been observed worldwide, particularly in Mexico, which is why some authors propose that It is a silent p andemic that has not been monitored. The understanding of the etiological factors of this pathology can help to understand a little more the factors to which we are predisposed in our environment." 1009 1721 W4309599585.pdf 0 13 separator 0.97127795 ¶ 1723 1725 W4309599585.pdf 0 14 paratext 0.8045243 "Published On: 22 November 2022 ¶ ¶ Available on: https://ijmscr.org/" 1727 1821 W4309599585.pdf 0 15 separator 0.88158315 "¶ ¶" 1823 1833 W4309599585.pdf 0 16 title 0.9879715 INTRODUCTION 1833 1846 W4309599585.pdf 0 17 separator 0.99447453 ¶ 1848 1850 W4309599585.pdf 0 18 text 0.99484044 "Gastroschisis is a congenital anomaly of the d evelopment of the ventral body wall, first described in 1733 characterized by the presence of a hole less than 2 cm in diameter in the abdominal wall, which allows evisceration of the intestinal loops and sometimes from the colon and other organs. Because it is not surrounded by amnion, the intestine is directly exposed to the amniotic fluid, with consequent swelling and possible damage to the seromuscular layer. Evisceration also explains the high maternal serum levels of α-fetoprotein, even higher than i n the case of omphalocele . Depending on the extent of the defect, surgical reduction can be performed immediately after birth in order to avoid thermal and evaporative loss. through the exposed organs or gradually until complete closure, a modality that has shown an overall survival rate of more than 90%. 1,2" 1850 2766 W4309599585.pdf 0 19 separator 0.8907971 ¶ 2767 2769 W4309599585.pdf 0 20 text 0.9994613 "Gastroschisis occurs predominantly to the right of the umbilical cord insertion .Rarely, it may be located on the left side but always, in contrast to the midline location of other ventral body wall abnormalities, such as omphalocele, ectopy of the heart, exstrophy of the bladder and cloaca, pentalogy Cantrell and extremity -body wall complex. Other malformations can occur simultaneously with gastroschisis - in 10 -20% of cases - especially in the gastroi ntestinal tract, such as malrotation, volvulus, stenosis and atresia. Rarer still are other types of comorbidities, such as defects of the neural tube or diaphragm, ectopia cordis or congenital heart disease." 2769 3464 W4309599585.pdf 0 21 separator 0.9390317 ¶ 3465 3467 W4309599585.pdf 0 22 text 0.9963118 "In order to explain why the prevalence of the m alformation has shown an increasing global trend in recent decades, Especially in young mothers and/or with a history of alcohol and tobacco consumption during pregnancy, multiple studies have been carried out that suggest the participation of various environmental and genetic predisposition factors as an important cause of risk. However, and despite the diversity of factors involved, to date there is no conclusive evidence about the cause of the malformation. 3,4,5" 3467 4010 W4309599585.pdf 0 23 separator 0.9944596 ¶ ¶ 4012 4018 W4309599585.pdf 0 24 title 0.9919788 "ORIGIN OF GASTROSCHISIS: ANATOMICAL EVENTS" 4018 4064 W4309599585.pdf 0 25 separator 0.9945164 ¶ 4066 4068 W4309599585.pdf 0 26 text 0.9997371 "Until the last decade it was stated that gastroschisis was an independent malformation of the umbilical cord and that it shared with the other congenital anomalies of the ventral body wall, except for omphalocele, a common embryonic mechanism associated with defective fusion of lateral body folds, as a cause of abnormal closure of the thoracic and abdominopelvic cavities. For omphalocele, a failure in the return of the intestinal loops from the umbilical coelom to the abdominal cavity was proposed, after the physiological herniation that normally must occur between the sixth and twelfth week of development. In agreement with these" 4069 4740 W4309599585.pdf 0 0 separator 0.9876405 ¶ ¶ 1 6 W2903960676.pdf 33 1 title 0.98313594 34 Mobility as a Service and Greener Transportation Systems in a Nordic Context 6 86 W2903960676.pdf 33 2 separator 0.9944649 ¶ 88 90 W2903960676.pdf 33 3 table 0.62049234  Passenger vehicle fleet evolution for each country, 91 145 W2903960676.pdf 33 4 text 0.5504107 145 146 W2903960676.pdf 33 5 table 0.5365925 including fleet composition ¶ 146 176 W2903960676.pdf 33 6 text 0.61484855 (i.e. % of new vehicles that are EV, P 176 215 W2903960676.pdf 33 7 table 0.489311 HEV 215 218 W2903960676.pdf 33 8 text 0.6513054 , 218 219 W2903960676.pdf 33 9 table 0.5135682 gasoline 219 228 W2903960676.pdf 33 10 text 0.59122527 , electric), vehicle 228 248 W2903960676.pdf 33 11 table 0.54811937 efficiency 248 259 W2903960676.pdf 33 12 text 0.5909734 , 259 260 W2903960676.pdf 33 13 table 0.5631282 ¶ vehicle weight 261 278 W2903960676.pdf 33 14 text 0.55752826 , % of 278 284 W2903960676.pdf 33 15 table 0.5122108 km driven 284 294 W2903960676.pdf 33 16 text 0.53616506 in electric 294 306 W2903960676.pdf 33 17 table 0.49122778 mode in P 306 316 W2903960676.pdf 33 18 text 0.5527127 HEV 316 319 W2903960676.pdf 33 19 table 0.50376576 s 319 320 W2903960676.pdf 33 20 text 0.64172137 , and 320 325 W2903960676.pdf 33 21 table 0.55625594 battery 325 333 W2903960676.pdf 33 22 text 0.50535506 333 334 W2903960676.pdf 33 23 table 0.6399476 sizes 334 339 W2903960676.pdf 33 24 text 0.56571037 , 339 340 W2903960676.pdf 33 25 table 0.9183602 "cost and weight.  CO2 emissions from electricity and battery production  Passenger transport activity for each country  Biofuel usage for each country" 340 506 W2903960676.pdf 33 26 separator 0.8912942 ¶ ¶ 507 513 W2903960676.pdf 33 27 text 0.998819 "While the above parameters are modelled under an anticipated development approach, the reference scenario is designed to allow for an impact assessment of varying degrees of MaaS implementation, and therefore involves a BAU approach in terms of each country’s deployment of MaaS." 513 802 W2903960676.pdf 33 28 separator 0.99716306 ¶ 803 805 W2903960676.pdf 33 29 title 0.9938241 4.1.2 Key parameters and assumptions 805 842 W2903960676.pdf 33 30 separator 0.98596 ¶ 843 845 W2903960676.pdf 33 31 title 0.9661484 Evolution of vehicle fleet 845 872 W2903960676.pdf 33 32 separator 0.98768985 ¶ 873 875 W2903960676.pdf 33 33 text 0.9997124 "The most important factor in terms of impact on CO 2 and other emissions is the composition of the vehicle fleet. In addition to the above-mentioned PETRA model, Ea Energy Analyses has developed a vehicle transport model for use in analyzing future transport vehicle trends and cost developments. These analyses found that from a socioeconomic perspective, i.e. when all costs associated with vehicle ownership and use are incorporated, it is most likely that EVs and/or PHEVs will become cheaper than their gasoline and diesel counterparts before 2030, and perhaps prior to 2025." 875 1474 W2903960676.pdf 33 34 paratext 0.90577304 62 63 1474 1479 W2903960676.pdf 33 35 text 0.9994199 "It is assumed that this socioeconomic tipping point will translate to a private end-user cost tipping point in the early to mid-2020s, thus driving EV and PHEV growth from this time period and accelerating through to 2050. Norway represents the most well-known example in this regard, because as soon as it was cost-effective to select an EV or PHEV over an ICE vehicle (both monetarily, but also incorporating other privileges related to parking and utilization of bus lanes), sales of electric drive vehicles grew rapidly." 1479 2022 W2903960676.pdf 33 36 separator 0.9668739 ¶ 2024 2026 W2903960676.pdf 33 37 text 0.99905574 "Based on the assumption that it will be cost-effective for the majority of consumers to elect a PHEV or EV by 2040, it becomes more a question of how quickly this shift to electric vehicles will occur in each of the 5 Nordic countries. The future scenario assumptions therefore take their point of departure in the current distribution of new passenger vehicle sales and converge to a situation in 2040 that is dominated by electric vehicle sales. Some countries are already well on their way (Norway), so they are assumed to have higher electric vehicle penetration rates in 2030. In the longer term, it is assumed that a continuing fall in battery prices and increased energy density will result in the majority of commuters being able to rely on an EV for their driving needs, while larger geographic countries (Sweden, Norway, Finland) are assumed to rely on ¶" 2026 2919 W2903960676.pdf 33 38 separator 0.9641991 ¶ ¶ 2985 2991 W2903960676.pdf 33 39 bibliography 0.9914763 62 Ea Energy Analyses. (2016). Green Roadmap 2030. Copenhagen: Ea Energy Analyses. 2991 3074 W2903960676.pdf 33 40 separator 0.9507283 ¶ 3075 3077 W2903960676.pdf 33 41 bibliography 0.9917477 63 Ea Energy Analyses. (2017). Green Transport Roadmap - 30% CO2 reduction in EU road transport towards 2030. 3077 3187 W2903960676.pdf 33 42 separator 0.96494997 ¶ 3188 3190 W2903960676.pdf 33 43 bibliography 0.9393621 Copenhagen: Ea Energy Analyses, The Ecologocial Council, Energifonden. 3190 3261 W2903960676.pdf 33 0 paratext 0.99083 Page 18/25 0 10 W4251081326.pdf 17 1 separator 0.99532604 ¶ 10 12 W4251081326.pdf 17 2 caption 0.8722255 Figure 1 12 21 W4251081326.pdf 17 3 separator 0.9790491 ¶ 21 23 W4251081326.pdf 17 4 caption 0.9931937 Phenotype, microstructure and photosynthesis changes in leaves of winter rapeseed under freezing treatment (A), 23 135 W4251081326.pdf 17 5 separator 0.66588545 ¶ 135 137 W4251081326.pdf 17 6 caption 0.9843036 "Illustration of 5-week-old winter rapeseed plants after freezing treatment. (B), The net photosynthetic rates of both winter rapeseed cultivars after freezing treatment. P-values are means ± SD from three biological replicates (p<0.05). (C)," 137 381 W4251081326.pdf 17 7 separator 0.9106299 ¶ 381 383 W4251081326.pdf 17 8 caption 0.9815667 Ultrastructure changes in both winter rapeseed cultivars after freezing treatment for 24 h and control, respectively. C, 383 504 W4251081326.pdf 17 9 separator 0.64304876 ¶ 504 506 W4251081326.pdf 17 10 text 0.4559764 chloroplast; CW, cell wall; M, 506 537 W4251081326.pdf 17 11 table 0.4760231 mitochondri 537 549 W4251081326.pdf 17 12 text 0.47527668 on; P, plasto 549 562 W4251081326.pdf 17 13 table 0.42854428 glob 562 566 W4251081326.pdf 17 14 text 0.5346179 ulus; PB, protein body; S, starch grain; T, thylakoid. 566 620 W4251081326.pdf 17 0 table 0.6119835 2004; four males, five females, 0 31 W2155861125.pdf 16 1 bibliography 0.5596308 "tributary of Rondgat River near Algeria, Cederberg Wilderness Area," 31 101 W2155861125.pdf 16 2 table 0.4774057 32 u22.411 9S, 19u 101 120 W2155861125.pdf 16 3 bibliography 0.4362885 03. 120 123 W2155861125.pdf 16 4 table 0.4523884 863 9E, 123 130 W2155861125.pdf 16 5 bibliography 0.47983253 1 November 2004 130 146 W2155861125.pdf 16 6 table 0.5138639 ; one male, D 146 159 W2155861125.pdf 16 7 bibliography 0.46576148 warsriver, alt. ¶ 159 176 W2155861125.pdf 16 8 table 0.47047314 861 m 176 182 W2155861125.pdf 16 9 bibliography 0.4394451 182 183 W2155861125.pdf 16 10 table 0.480052 a.s.l., 32 u29.973, 19 u15.389 9E, 183 217 W2155861125.pdf 16 11 bibliography 0.42397538 2 217 219 W2155861125.pdf 16 12 table 0.67419285 November 2004; two males, seven females, 219 260 W2155861125.pdf 16 13 separator 0.51104915 ¶ 260 262 W2155861125.pdf 16 14 table 0.5090838 Drie 262 267 W2155861125.pdf 16 15 bibliography 0.55701554 hoeksriver, south of Uitkykpas, 267 298 W2155861125.pdf 16 16 table 0.47201574 Ce 298 301 W2155861125.pdf 16 17 bibliography 0.5176128 derberg Wilderness Area, alt. 301 330 W2155861125.pdf 16 18 table 0.4917862 947 m 330 336 W2155861125.pdf 16 19 bibliography 0.5092662 a.s.l.,32u25. 336 350 W2155861125.pdf 16 20 table 0.44593254 527 350 353 W2155861125.pdf 16 21 bibliography 0.48579282 9S, 19u07.895 9 353 369 W2155861125.pdf 16 22 table 0.46768993 E, 369 371 W2155861125.pdf 16 23 bibliography 0.52998906 2 371 373 W2155861125.pdf 16 24 table 0.6726482 "November 2004; five males, five females, one nymph, Tou" 373 431 W2155861125.pdf 16 25 bibliography 0.5318016 ws River at crossing with Old George–Knysna Road 431 479 W2155861125.pdf 16 26 table 0.534262 ", alt. 123 m a.s.l, 33 u56.793 9S, 22u36.751 9E, 13 November 2004; one female, Wood" 479 564 W2155861125.pdf 16 27 bibliography 0.37477565 ville 564 569 W2155861125.pdf 16 28 table 0.47242063 River at crossing with 569 592 W2155861125.pdf 16 29 bibliography 0.45641237 "George– Karata road" 592 614 W2155861125.pdf 16 30 table 0.52863246 , alt. 100 m a.s.l., 33 u56.207 9S, 22u 614 653 W2155861125.pdf 16 31 bibliography 0.4280506 39 653 655 W2155861125.pdf 16 32 table 0.48089844 .857 9E, 655 663 W2155861125.pdf 16 33 bibliography 0.48308712 13 November 663 675 W2155861125.pdf 16 34 table 0.52440214 2004; three males, 675 694 W2155861125.pdf 16 35 separator 0.43524823 694 695 W2155861125.pdf 16 36 table 0.33308718 ¶ 695 696 W2155861125.pdf 16 37 bibliography 0.4647635 seven 696 703 W2155861125.pdf 16 38 table 0.45010346 females 703 710 W2155861125.pdf 16 39 bibliography 0.45458436 , seven 710 718 W2155861125.pdf 16 40 table 0.48180658 nymph 718 723 W2155861125.pdf 16 41 bibliography 0.5558047 "s, Bloukrans River at crossing with road R102 (near border with Eastern Cape Province), no coordinates measurement possible, 15 November 2004." 723 867 W2155861125.pdf 16 42 separator 0.99420494 ¶ 867 869 W2155861125.pdf 16 43 table 0.3572744 South Africa 869 882 W2155861125.pdf 16 44 bibliography 0.44644585 , Kwazulu-Natal Province: one 882 911 W2155861125.pdf 16 45 table 0.48977584 male 911 916 W2155861125.pdf 16 46 bibliography 0.4448756 , one 916 921 W2155861125.pdf 16 47 table 0.46429 female 921 928 W2155861125.pdf 16 48 bibliography 0.5372504 ", Pholelana River at Cobham Office," 928 965 W2155861125.pdf 16 49 table 0.46666133 Drakensbergen, alt 965 984 W2155861125.pdf 16 50 bibliography 0.49874815 . 984 985 W2155861125.pdf 16 51 table 0.4712772 1619 985 990 W2155861125.pdf 16 52 bibliography 0.50403625 990 991 W2155861125.pdf 16 53 table 0.50938004 a 991 992 W2155861125.pdf 16 54 bibliography 0.47878447 .s.l., 29 u41.963 992 1009 W2155861125.pdf 16 55 table 0.4816803 9 1009 1011 W2155861125.pdf 16 56 bibliography 0.516115 S, 29u24.791 9’ 1011 1026 W2155861125.pdf 16 57 table 0.46455324 E 1026 1027 W2155861125.pdf 16 58 bibliography 0.5013847 , 17 November 2004; 1027 1046 W2155861125.pdf 16 59 separator 0.39694798 1046 1047 W2155861125.pdf 16 60 table 0.5276626 ¶ one female, Lo 1047 1063 W2155861125.pdf 16 61 bibliography 0.50012654 theni 1063 1068 W2155861125.pdf 16 62 table 0.60116637 "River, Drakensbergen, alt. 1400 m a.s.l., 29 u27.877 9S, 29u32.219 9E, 18 November 2004; two males, one nymph, Poa" 1068 1185 W2155861125.pdf 16 63 bibliography 0.5187674 cher’s Stream, Injisutu, 1185 1209 W2155861125.pdf 16 64 table 0.55240333 Drakensbergen, 1209 1224 W2155861125.pdf 16 65 bibliography 0.47825983 ¶ 1224 1226 W2155861125.pdf 16 66 table 0.58224374 1512 m a.s.l., 29 u08.141 9S, 29u26.149 9E, 19 November 2004; one female, Sigibundu 1226 1310 W2155861125.pdf 16 67 bibliography 0.47401735 ¶ Stream, Royal Natal National Park, 1310 1347 W2155861125.pdf 16 68 table 0.4455822 alt 1347 1351 W2155861125.pdf 16 69 bibliography 0.48221436 . 1351 1352 W2155861125.pdf 16 70 table 0.460488 1375 m 1352 1359 W2155861125.pdf 16 71 bibliography 0.4826156 1359 1360 W2155861125.pdf 16 72 table 0.46955442 a.s.l. 1360 1366 W2155861125.pdf 16 73 bibliography 0.45370585 , 28 1366 1370 W2155861125.pdf 16 74 table 0.43294904 u 1370 1372 W2155861125.pdf 16 75 bibliography 0.45170802 40 1372 1374 W2155861125.pdf 16 76 table 0.43513668 .918 9 1374 1380 W2155861125.pdf 16 77 bibliography 0.46652028 S, 28u58.017 9 1380 1394 W2155861125.pdf 16 78 table 0.45165503 E 1394 1395 W2155861125.pdf 16 79 bibliography 0.55654824 , 20 1395 1399 W2155861125.pdf 16 80 separator 0.9870306 ¶ 1399 1401 W2155861125.pdf 16 81 bibliography 0.73897713 "November 2004. Namibia: nine males, 13 females, Zambezi River, Katima Mulilo, 20 July1996; two males, Okavango River at Popa Falls, 21 July 1996; 37 males, 39 females, Cubango River, Rundu, 24 July 1996." 1401 1607 W2155861125.pdf 16 82 separator 0.9957378 ¶ 1607 1609 W2155861125.pdf 16 83 title 0.9773183 Remarks 1609 1617 W2155861125.pdf 16 84 separator 0.99199617 ¶ 1617 1619 W2155861125.pdf 16 85 text 0.98376393 "Hygrobates soari is the most widespread African Hygrobates species and probably occurs everywhere south of the Sahara." 1619 1740 W2155861125.pdf 16 86 separator 0.9861573 ¶ 1740 1742 W2155861125.pdf 16 87 caption 0.706664 Hygrobates (Hygrobates) sanguineus K. Viets, 1956 1742 1793 W2155861125.pdf 16 88 separator 0.38611564 ¶ 1793 1794 W2155861125.pdf 16 89 caption 0.6212253 (Figure 18) 1794 1806 W2155861125.pdf 16 90 separator 0.99354935 ¶ 1806 1808 W2155861125.pdf 16 91 title 0.965293 Material examined 1808 1826 W2155861125.pdf 16 92 separator 0.98114586 ¶ 1826 1828 W2155861125.pdf 16 93 text 0.6751692 "Holotype: male, Great Berg River, Western Cape Province, South Africa, 11 January 1953, leg. Harrison (slide 7788, SMF). Other material: South Africa, Western Cape Province" 1828 2003 W2155861125.pdf 16 94 table 0.4424793 :five 2003 2008 W2155861125.pdf 16 95 text 0.49890092 males, seven 2008 2022 W2155861125.pdf 16 96 table 0.44655567 nymphs, 2022 2029 W2155861125.pdf 16 97 text 0.53195107 Wolwekloof River 2029 2046 W2155861125.pdf 16 98 table 0.42056617 at 2046 2049 W2155861125.pdf 16 99 text 0.49604213 Tweede Tol, Limietberg NR, alt. 285 2049 2085 W2155861125.pdf 16 100 table 0.41313362 "m a.s.l" 2085 2095 W2155861125.pdf 16 101 text 0.4027727 ., 33 2095 2101 W2155861125.pdf 16 102 table 0.39673918 u34. 2101 2105 W2155861125.pdf 16 103 text 0.41096538 115 9 2105 2110 W2155861125.pdf 16 104 table 0.3965607 S 2110 2111 W2155861125.pdf 16 105 text 0.42997542 , 19u08.255 9E, 3 November 2004. 2111 2143 W2155861125.pdf 16 106 separator 0.9962648 ¶ 2143 2145 W2155861125.pdf 16 107 title 0.81827116 Description 2145 2157 W2155861125.pdf 16 108 separator 0.9895236 ¶ 2157 2159 W2155861125.pdf 16 109 text 0.98568875 "Male. Idiosoma 648–778 long and 421–599 wide. Shape of idiosoma variable, some specimens elongated with tapering posterior idiosoma part. In older males all glandularia surrounded by red-coloured secondary sclerotization. Close to anterior margin of genital field a pair of glandularia, fused with secondary sclerotization in older males, separated in a teneral male. I-leg-6 with one heavy, blunt seta." 2159 2571 W2155861125.pdf 16 110 separator 0.7669687 ¶ 2571 2573 W2155861125.pdf 16 111 text 0.87178266 Female. Unknown. 2573 2590 W2155861125.pdf 16 112 separator 0.99336106 ¶ 2590 2592 W2155861125.pdf 16 113 title 0.8169178 Remarks 2592 2600 W2155861125.pdf 16 114 separator 0.9653549 ¶ 2600 2602 W2155861125.pdf 16 115 text 0.99027777 "K. Viets (1956) based his description on one teneral and one fully sclerotized male. In his description, he did not mention the occurrence of a pair of glandularia close to or fused3384 H. Smit" 2602 2798 W2155861125.pdf 16 116 separator 0.9237571 ¶ 2798 2800 W2155861125.pdf 16 117 paratext 0.97862554 Downloaded by [University of Bath] at 15:07 13 February 2014 2800 2861 W2155861125.pdf 16 118 separator 0.99617743 ¶ 2862 2864 W2155861125.pdf 16 0 paratext 0.9853237 AppliedMathematicsandNonlinearSciences8(1)(2023)1841-1848 1846 0 62 W4312501373.pdf 5 1 separator 0.9932348 ¶ 62 64 W4312501373.pdf 5 2 text 0.9975617 "informationoflibraryusersonitemsandranksthem.Thefunctionconvertstheinputlibrary userinformationanditemratinginformationintocorrespondingkey-valuepairs.Thefunction mergesratingitemswiththesameuser.Thesecondisdevotedtocalculatingthesimilarity betweenitems.Weconvertkey-valuepairsbetweenlibraryusersandprojectsintokey-value pairsbetweenprojectsandprojects.WeusetheMapfunctiontoobtainthescoresofthesame UseramongeachItem.Atthesametime,weusetheReducefunctiontocalculatethe similaritybetweenitems.AftertwotimesofMapReduceprocessing,wecangetthe calculationresultofsimilarityandthesimilaritylistofeachItem[9].Finally,wecalculatethe similaritylistofrecommendationscoresoflibraryusersbasedonMapReduce.Inthispaper, theMapfunctionisusedforCFrecommendation,andthefunctionReduceisusedtooutput therecommendationresults." 64 889 W4312501373.pdf 5 3 separator 0.996984 ¶ 889 891 W4312501373.pdf 5 4 title 0.9920079 3.ExperimentandVerification 891 919 W4312501373.pdf 5 5 separator 0.9953152 ¶ 919 921 W4312501373.pdf 5 6 title 0.9923587 3.1DatasetandEvaluationCriteria 921 953 W4312501373.pdf 5 7 separator 0.9961713 ¶ 953 955 W4312501373.pdf 5 8 text 0.9991485 "Theexperimentalevaluationcriteriainthispapermainlyincludetwoaspects:First,wetest whethertheparallelminingofbigdatabasedonHadoopcanimprovetheperformanceofthe modelcalculation.Thesecondistotestsituationalrecommendationmitigationtoreduce recommendationaccuracycausedbydatasparsity[10].Thespeedupratioismainlyusedto comparethetimeittakesforaspecificalgorithmtorunintwodifferentenvironments,single- machine,andparallelcomputing.Thecalculationmethodistheratiobetweentherunning timeofasinglemachineandtherunningtimeofaparallelmachine:S=T(1)/T(N).Among them,T(1)isthealgorithm'srunningtimeinastand-aloneenvironment.T(N)isthetimefor multi-machineparallelprocessing.Thispaperintroducesthemostcommonmeanabsolute deviationMAEinrecommendationperformancetesting.Thecalculationformulais:" 955 1746 W4312501373.pdf 5 9 separator 0.8982489 ¶ 1746 1748 W4312501373.pdf 5 10 math 0.8176095 "1||N ipiqiMAEN(14) ¶" 1748 1775 W4312501373.pdf 5 11 text 0.89587134 "12{,,,}N pp p isthesetofuserratingspredictedbythealgorithm.12{,,,}n qq q isa collectionofactualuserratings." 1775 1889 W4312501373.pdf 5 12 separator 0.99717975 ¶ 1889 1891 W4312501373.pdf 5 13 title 0.99304336 3.2Analysisofexperimentalresults 1891 1924 W4312501373.pdf 5 14 separator 0.99634767 ¶ 1924 1926 W4312501373.pdf 5 15 text 0.9992419 "ThispartadoptsthespeedupratioStoanalyzetheperformanceofthecontextualized recommendationalgorithm.Datadistributionisfirstperformedonthedataset.Wedefine themasdatasetsD1,D2,D3,andD4,respectively.Itcontainsdatasetsof1000,2000,3000, and4000userratings[11].Thispaperteststheparallelrunningtimeoftheabovedatasetsin theHadoopenvironment.Weselected2,4,6,and8caseswithdifferentnumbersofrunning nodes,respectively.Atthesametime,werecordedtherunningtimeoftheD1-D4datasetin theabovefourcases(Fig.2)." 1926 2426 W4312501373.pdf 5 0 paratext 0.9883318 | 1245 3 10 W3132851878.pdf 10 1 separator 0.87204295 ¶ 10 12 W3132851878.pdf 10 2 title 0.97266203 CHOUDRY et al. 12 27 W3132851878.pdf 10 3 separator 0.9757822 ¶ 27 29 W3132851878.pdf 10 4 text 0.97144485 "were again no differences in the MK numbers and ploidy distribution between groups (Figure S6)." 29 128 W3132851878.pdf 10 5 separator 0.6549548 ¶ 128 130 W3132851878.pdf 10 6 text 0.9967638 "We sequenced a total of 156 pools of 50 to 100 MKs (irrespec - tive of ploidy); 101 pools from seven individuals with severe cor - onary disease and recent myocardial infarction and 55 pools from eight non- CAD controls. Differential gene expression analysis re - vealed 139 upregulated (FDR <0.05; 21 DEG with an FDR <0.00010) and 679 downregulated (FDR <0.05; 62 DEG with an FDR <0.0001) genes in MKs from patients with severe coronary disease and recent myocardial infarction (Tables S27, S28). A number of upregulated genes were directly related to platelet activation and proteins se-creted by the alpha granule including the neutrophil chemoattrac - tant CXCL7 ( PPBP ), THBS1 , and RAP1B as well as the cell surface glutamate receptor GRIA1 (Table 2)." 130 905 W3132851878.pdf 10 7 caption 0.9450071 "FIGURE 5 Index sorting of single HSCs. (A) Retrospective analysis of FACS sorting strategy for each individual HSC sorted. Left panel: CD34 vs CD38; middle panel: CD90 vs CD45RA; right panel: CD90 vs CD49 f. Individual surface marker expression was normalized. Cluster 1: red; cluster 2: yellow; cluster" 905 1215 W3132851878.pdf 10 8 table 0.46433765 3: 1215 1218 W3132851878.pdf 10 9 caption 0.87162536 green; cluster 4: blue; cluster 5: magenta; cells filtered because of poor quality: gray. (B) Retrospective analysis of FACS index data: FSC- A vs CD34 for each HSC sorted. Cluster 1218 1400 W3132851878.pdf 10 10 table 0.3682777 1 1400 1402 W3132851878.pdf 10 11 caption 0.36026666 ( 1402 1404 W3132851878.pdf 10 12 table 0.44746935 red): 1404 1409 W3132851878.pdf 10 13 text 0.48621956 FSC- 1409 1414 W3132851878.pdf 10 14 table 0.51085174 "A Hi" 1415 1422 W3132851878.pdf 10 15 text 0.47378612 CD34Hi; 1422 1431 W3132851878.pdf 10 16 table 0.54877436 cluster 4 1431 1440 W3132851878.pdf 10 17 text 0.45426795 ( 1440 1442 W3132851878.pdf 10 18 table 0.5085955 blue): 1442 1448 W3132851878.pdf 10 19 text 0.48977217 1448 1449 W3132851878.pdf 10 20 table 0.46074563 FSC 1449 1452 W3132851878.pdf 10 21 text 0.50504076 - AH 1452 1457 W3132851878.pdf 10 22 table 0.4435016 i CD 1457 1461 W3132851878.pdf 10 23 text 0.44130751 34 1461 1463 W3132851878.pdf 10 24 table 0.52600443 Lo 1463 1465 W3132851878.pdf 10 25 text 0.41257757 ; 1465 1466 W3132851878.pdf 10 26 table 0.53680074 "cluster 2" 1466 1479 W3132851878.pdf 10 27 text 0.45394266 ( 1479 1481 W3132851878.pdf 10 28 table 0.5983128 yellow 1481 1487 W3132851878.pdf 10 29 text 0.4816851 ): 1487 1490 W3132851878.pdf 10 30 table 0.47556058 FSC 1490 1493 W3132851878.pdf 10 31 text 0.47465867 - AL 1493 1498 W3132851878.pdf 10 32 table 0.73250294 "o CD34Hi. Individual surface marker expression was normalized. Cluster 1: red; cluster 2: yellow; cluster 3: green; cluster 4: blue; cluster 5: magenta; cells filtered because of poor quality: gray. FACS, fluorescence- activated cell sorting; HSC, hematopoietic stem cell" 1498 1773 W3132851878.pdf 10 33 separator 0.8905903 ¶ 1774 1776 W3132851878.pdf 10 34 table 0.99259514 "A BCD34_AF700NA54321 NA54321 NA54321 NA54321 CD38_PerCP–83.0 3.5 4.0 3.0 2.5 3.5 4.0 3.0 2.5 3.03.5 3.54.0 4.0 –6 –4 –2 02 –2 –1 01 2 2.53 .0 3.54 .0 4.5 50000 100000 150000 CD45RA_PBCD90_PeCy7 CD49f_PECD90_PeCy7 CD34_AF700 FSC_A" 1776 2034 W3132851878.pdf 10 35 separator 0.98507756 ¶ 2034 2036 W3132851878.pdf 10 36 caption 0.98834336 FIGURE 6 Prospective identification of HSC clusters. (A) Principal component analysis (PC2/PC3) of FACS surface marker expression 2036 2167 W3132851878.pdf 10 37 separator 0.5168619 ¶ 2168 2170 W3132851878.pdf 10 38 caption 0.99041444 "for each individual HSC sorted, including: FSC- A, SSC- A, Lin, CD34, CD38, CD45RA, CD90, CD49 f. Vector loading for FSC- A, CD34, and CD49f are shown. Cluster 1: red; cluster 2: olive; cluster 3: green; cluster 4: blue; cluster 5: magenta. (B) Projection of FACS surface marker" 2170 2455 W3132851878.pdf 10 39 separator 0.889899 ¶ 2456 2458 W3132851878.pdf 10 40 caption 0.59797084 expression 2458 2469 W3132851878.pdf 10 41 text 0.84362465 of HSCs characterized by differentiation assay and their lineage output from Belluschi et al36 onto Figure 6A. As in Figure 6A: 2469 2597 W3132851878.pdf 10 42 separator 0.45144644 ¶ 2598 2600 W3132851878.pdf 10 43 text 0.57007396 cluster 1: red; cluster 2: olive; cluster 3: green; cluster 4: blue; cluster 5: magenta. Differentiation assay outputs: erythrocyte: yellow; MK: violet; multipotent progenitor: pink; myelocyte: gray. Shaded areas: red: cluster 1; blue: cluster 4; yellow: erythrocyte output; violet: MK. The violet triangle in the middle of 2600 2924 W3132851878.pdf 10 44 caption 0.5130898 the figure 2924 2935 W3132851878.pdf 10 45 text 0.77362853 shows the HSCs from Belluschi et al that formed MKs. The blue shaded area encompasses the position of cells in cluster 4; the pink shaded area encompasses the position of the cells in cluster 2935 3127 W3132851878.pdf 10 46 caption 0.48352385 1. 3127 3130 W3132851878.pdf 10 47 table 0.57414585 "FACS, fluorescence- activated cell sorting; HSC, hematopoietic stem cell; MK, megakaryocyte" 3130 3226 W3132851878.pdf 10 48 separator 0.9943815 ¶ 3227 3229 W3132851878.pdf 10 0 paratext 0.9584592 "J. Technol. Manag. Innov. 2021. Volume 16, Issue 4 ISSN: 0718-2724. (http://jotmi.org)" 0 88 W4225995542.pdf 12 1 separator 0.9793867 ¶ 88 90 W4225995542.pdf 12 2 paratext 0.91162056 Journal of Technology Management & Innovation © Universidad Alberto Hurtado, Facultad de Economía y Negocios.108 90 203 W4225995542.pdf 12 0 paratext 0.9848311 2 0 1 W3139818743.pdf 1 1 separator 0.496602 1 2 W3139818743.pdf 1 2 paratext 0.95889896 "¶ Volume 117| Number 3/4 March/April 2021Research Letter https://doi.org/10.17159/sajs.2021/8837" 2 104 W3139818743.pdf 1 3 separator 0.9422201 ¶ 104 106 W3139818743.pdf 1 4 title 0.98695594 Shark–seal interaction during the early Pliocene 107 156 W3139818743.pdf 1 5 separator 0.6222745 ¶ 156 158 W3139818743.pdf 1 6 paratext 0.98896945 Page 2 of 5 159 171 W3139818743.pdf 1 7 separator 0.9946593 ¶ 171 173 W3139818743.pdf 1 8 text 0.9979523 "Bone fragments are embedded in the bone cortex due to the force of a bite or the pressure causing the fracture (Figure 2a). The bites are preserved on the shaft and distal part of the bone. These specimens were collected in 1976 from MPPM as part of an excavation. The bites described below follow Govender and Chinsamy8:" 173 507 W3139818743.pdf 1 9 separator 0.93136835 ¶ 508 510 W3139818743.pdf 1 10 text 0.9811667 "1. CF1 damage can be subdivided into two types (herein designated serrated Types CF1a and CF1b); CF1a is a simple, superficial groove with dotted markings left by serrations, whereas CF1b is a deeper groove with ridges and grooves caused by tooth serrations. 2. CF2 is a simple groove with tapered end and no trace of serrations. 3. CF3 damage has subparallel ridges and grooves corresponding with the tooth’s serrated edge. There is no cut groove. 4. CF4 damage suggests cutting and/or scraping action with rotating movement. This action leaves curvilinear markings caused by the rotation of the tooth." 510 1135 W3139818743.pdf 1 11 separator 0.97800434 ¶ 1135 1137 W3139818743.pdf 1 12 caption 0.7800644 ab 1137 1140 W3139818743.pdf 1 13 separator 0.95677114 ¶ 1140 1142 W3139818743.pdf 1 14 caption 0.9933567 "Figure 1: (a) Locality map showing the location of Langebaanweg during the 30-m high (the modern coastline is shown in grey). (b) Abbreviated stratigraphic section of Langebaanweg [Konings Vlei Gravel (KGM), Langeberg Quartz Sand (LQSM) and Muishond Fontein Pelletal Phosphorite (MPPM) Members] showing the fossil finds concentrated between 26 m and 30 m above sea level (m asl) (after Roberts et al.13; Govender and Chinsamy8; Govender et al.28)." 1142 1600 W3139818743.pdf 1 15 separator 0.99706995 ¶ 1600 1602 W3139818743.pdf 1 16 title 0.9756742 Table 1: List of seal specimens with the number and type of bites identified 1602 1680 W3139818743.pdf 1 17 separator 0.98749673 ¶ 1680 1682 W3139818743.pdf 1 18 table 0.96778363 "Element Specimen number Locality Number of bites CF1 CF2 CF3 CF4 Incomplete right humerusSAM-PQL-34631MPPM (BCWW T2 area RS)2 – – x – Incomplete right humerusSAM-PQL-60698MPPM (W Wall IWRP 1976/2)19 x x – –" 1682 1905 W3139818743.pdf 1 0 paratext 0.98429316 1883 0 4 W2175426920.pdf 2 1 separator 0.62340367 ¶ 5 7 W2175426920.pdf 2 2 paratext 0.90124995 Influence of the manipulation technique... PITHON, M . M. et al. 7 71 W2175426920.pdf 2 3 separator 0.61884725 ¶ 72 74 W2175426920.pdf 2 4 paratext 0.8724102 Biosci. J., Uberlândia, v. 31, n. 6, p. 1881-1886, Nov./Dec. 20 15 74 141 W2175426920.pdf 2 5 title 0.99136305 Statistical procedure 141 163 W2175426920.pdf 2 6 separator 0.995685 ¶ 164 166 W2175426920.pdf 2 7 text 0.9926978 "For descriptive analysis of the force values (N) means and standard deviations were calculated, with the differences between the methods (pressing vs. addition) being compared by the Student’s t-tes t for independent samples, after verification of the data’s normality using the Kolmogorov-Smirnov test. The significance level was set at 5% ( α = 0.05). Data were tabulated and analyzed using the statistical program BioEstat (version 5.0, Belém, PA, Brazil)." 166 653 W2175426920.pdf 2 8 separator 0.99456406 ¶ ¶ 654 660 W2175426920.pdf 2 9 title 0.9907139 RESULTS 660 668 W2175426920.pdf 2 10 separator 0.99063003 ¶ ¶ 669 675 W2175426920.pdf 2 11 text 0.9944453 "During this process, the compressive force was measured at the time of fracture for each plate individually, creating an average for the two teste d groups. Group 1 - addition technique - variance average was 79.12 N and Group 2 - pressing technique - average 77.07 N. The standard deviation of Group 1 was 17.30 N and of Group 2 of 16.31 N. These data show that there was no statistically significant difference between the two tested methods (P=0.788)." 675 1156 W2175426920.pdf 2 12 separator 0.9280724 ¶ 1157 1159 W2175426920.pdf 2 13 text 0.9995452 "With respect the location of the sample fracture. In the group 1, 90% of the samples had vertical fracture in the lateral height and 10% had a combination of vertical fracture in the lateral hei ght and incipient cracks in the corrugated surface of palate. In group 2, 85% of the samples had vertical fracture in the lateral height, 5% had a combinatio n of vertical fracture in the lateral height and inci pient cracks in the corrugated surface of palate, and 10% had longitudinal fractures in the lateral height." 1159 1704 W2175426920.pdf 2 14 separator 0.99317336 ¶ 1705 1707 W2175426920.pdf 2 15 caption 0.95098615 "Figure 2 shows the mean values of the measured force at the time of fracture, according t o the method of handling the resin. Data show no significant differences in strength between the pressing method and the addition method." 1707 1947 W2175426920.pdf 2 16 separator 0.7701274 "¶ " 1948 1957 W2175426920.pdf 2 17 math 0.43923897 ¶ 1957 1958 W2175426920.pdf 2 18 separator 0.32740912 1960 1961 W2175426920.pdf 2 19 math 0.4515613 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 1961 2014 W2175426920.pdf 2 20 separator 0.7808046 "¶ ¶" 2016 2026 W2175426920.pdf 2 21 caption 0.9963794 "Figure 2 . Mean values ± standard deviations from the measur ed strength of the fracture time according to the method of handling the acrylic resin." 2026 2178 W2175426920.pdf 2 22 separator 0.97883636 "¶ ¶" 2179 2189 W2175426920.pdf 2 23 title 0.9905891 DISCUSSION 2189 2200 W2175426920.pdf 2 24 separator 0.9890491 ¶ ¶ 2201 2207 W2175426920.pdf 2 25 text 0.9960986 "The manipulation process of acrylic resin, although widely used, is little explored in dentist ry. In the results obtained from this study showed no statistical difference in resistance between the tw o existing methods of manipulation. These results are of great clinical importance given that there is st ill doubt about the best technique among professionals." 2207 2589 W2175426920.pdf 2 26 separator 0.719236 ¶ 2591 2593 W2175426920.pdf 2 27 text 0.9994633 "In study (GONÇALVES et al., 2008) on the resistance of acrylic resin in phosphate incorporation in addition to the monomer, concluded that resistance was not affected with the addition of this component, results that corroborat e the findings of this study." 2593 2864 W2175426920.pdf 2 28 separator 0.92740506 ¶ 2865 2867 W2175426920.pdf 2 29 text 0.9770582 "Some studies have shown that the polishing techniques of acrylic resin can influence its mechanical properties by increasing the ratio of monomers, especially when the polishing is chemical (MCCABE; BASKER," 2867 3086 W2175426920.pdf 2 30 bibliography 0.65414464 "1976; STAFF" 3086 3101 W2175426920.pdf 2 31 text 0.53385854 ORD 3101 3104 W2175426920.pdf 2 32 bibliography 0.89189756 "; BROOKS, 1985; KEDJANURE et al., 1999; RANTALA et al., 2003; RUIZ-GENAO et al., 2003; FALTERMEIER et al., 2007; SANTOS et al., 2013" 3104 3246 W2175426920.pdf 2 33 text 0.92249703 ). This high amount of residual monomer 3246 3285 W2175426920.pdf 2 34 separator 0.9778292 ¶ 3286 3288 W2175426920.pdf 2 0 paratext 0.8161197 "XXI CENTURY RENAISSANCE IN THE PARADIGM OF SCIENCE, EDUCATION AND TECHNOLOGY INNOVATIONS ¶ 411" 0 103 W4392568394.pdf 2 1 separator 0.9793562 ¶ 104 106 W4392568394.pdf 2 2 title 0.9826752 ИСПОЛЬЗОВАННАЯ ЛИТЕРАТУРА: 107 134 W4392568394.pdf 2 3 separator 0.96940696 ¶ ¶ 135 141 W4392568394.pdf 2 4 paratext 0.42428398 1. Научный журнал 141 160 W4392568394.pdf 2 5 bibliography 0.3798879 Современные наукоемкие технологии. 160 194 W4392568394.pdf 2 6 paratext 0.38674065 ISSN 194 199 W4392568394.pdf 2 7 bibliography 0.33013105 1812-7320 199 211 W4392568394.pdf 2 8 paratext 0.26600638 ¶ 211 212 W4392568394.pdf 2 9 text 0.3473768 «Перечень» ВАК ИФ 212 231 W4392568394.pdf 2 10 paratext 0.34555927 РИН 231 234 W4392568394.pdf 2 11 text 0.37170592 Ц 234 235 W4392568394.pdf 2 12 paratext 0.34376127 = 0,926 235 243 W4392568394.pdf 2 13 separator 0.9687835 ¶ 244 246 W4392568394.pdf 2 14 bibliography 0.9644643 "2. https://infourok.ru/sovremennye-podhody-i-aktualnye-problemy-prepodavaniya- inostrannogo-yazyka-aviacionnym-specialistam-vks-so-srednim-professionaln- 4227811.html" 246 417 W4392568394.pdf 2 15 separator 0.8906511 ¶ 418 420 W4392568394.pdf 2 16 bibliography 0.9862532 3. https://e-koncept.ru/2017/770394.htm 420 460 W4392568394.pdf 2 17 separator 0.9679335 ¶ 461 463 W4392568394.pdf 2 18 bibliography 0.99763155 "4. Гейхман Л. К. Интерактивное обучение общению как модель межкультурной коммуникации (Екатеринбург 2003) (стр. 11, страницы 16-17)" 463 598 W4392568394.pdf 2 19 separator 0.96993333 ¶ 599 601 W4392568394.pdf 2 20 bibliography 0.99536014 "5. Nizamaddinovna S.A. TIL VA MADANIYATNING LINGVOMADANIY ALOQALARI." 601 673 W4392568394.pdf 2 21 separator 0.9335013 ¶ 674 676 W4392568394.pdf 2 22 bibliography 0.99739087 "6. Садулаева А. Til va madaniyatning lingvomadaniy aloqalari //Развитие лингвистики и литературоведения и образовательных технологий в эпоху глобализации. – 2022. – Т. 1. – No. 1. – С. 62-64." 676 873 W4392568394.pdf 2 23 separator 0.9724657 ¶ 874 876 W4392568394.pdf 2 24 bibliography 0.9975415 "7. Atashova F. D., Ashirov D. XORIJIY TILLARNI O ‘QITISHDA MADANIYATSHUNOSLIK YONDASHUVINING AHAMIYATI //Educational Research in Universal Sciences. – 2023. – Т. 2. – No. 9. – С. 239-242." 876 1069 W4392568394.pdf 2 25 separator 0.97189844 ¶ 1070 1072 W4392568394.pdf 2 26 bibliography 0.997136 "8. Atashova F. D., Seytniyazova G. M. DEVELOPING COMMUNICATIVE COMPETENCE OF ESP LEARNERS ESP ЎҚУВЧИЛАРИНИНГ КОММУНИКАТИВ КОМПЕТЕНЦИЯСИНИ РИВОЖЛАНТИРИШ //Mental Enlightenment Scientific-Methodological Journal. – 2022. – Т. 2022. – No. 2. – С. 38-50." 1072 1330 W4392568394.pdf 2 27 separator 0.97568333 ¶ 1331 1333 W4392568394.pdf 2 28 bibliography 0.9977425 "9. Seytniyazova, G., & Atashova, F. (2022). THE CATEGORY OF PLURALITY IN RUSSIAN AND ENGLISH LANGUAGES. Educational Research in Universal Sciences, 1(1), 74–78. Retrieved from http://erus.uz/index.php/er/article/view/477" 1333 1560 W4392568394.pdf 2 29 separator 0.9806975 ¶ 1562 1564 W4392568394.pdf 2 30 bibliography 0.99781096 "10. Feruza A., Dilbar P., Firuza D. CENTRAL ASIAN JOURNAL OF THEORETICAL AND APPLIED SCIENCES. – 2021." 1564 1670 W4392568394.pdf 2 31 separator 0.9663947 ¶ 1671 1673 W4392568394.pdf 2 32 bibliography 0.9667312 "11. Садуллаева Альфия Низамаддиновна СТИЛИСТИЧЕСКИЙ АНАЛИЗ КОНЦЕПТА «МУҲАББАТ» (ЛЮБОВЬ) В ПРОИЗВЕДЕНИИ «ТЕРБЕНБЕС» // European journal of literature and linguistics. 2023. No2. URL: https://cyberleninka.ru/article/n/stilisticheskiy-analiz-kontsepta-mu-abbat-lyubov-v- proizvedenii-terbenbes" 1673 1974 W4392568394.pdf 2 33 separator 0.9947032 ¶ 1977 1979 W4392568394.pdf 2 0 text 0.9997592 condition (M = 0.10; Figure 4, Cluster 3), which was significantly more often than adults who fit the predicted pattern (β = -4.66, SE = 0.76, p < 0.05). This group otherwise made adult-like judgments of the Direct Perception and Inference sentences, indicating that their only difficulty was in understanding that “I saw that...” could be used to report inference. Somewhat unexpectedly, about half of the children (n = 12) judged all of the target sentences in every condition as “right” (Figure 4, Cluster 4), even in the Doesn’t See condition where Mary saw nothing. However, these children were at ceiling for the control sentences, so their incorrect responses were not due to an overall “right” bias or a total failure to understand the task. When asked follow up questions at the end of the experiment, the children in this group confirmed that Mary was wearing her blindfold and could not see during the event in the See Evidence or Doesn’t See trials, so they were not confused or mistaken about her visual access in these trials. Instead, many of these children said that Mary’s see statement was correct because “I/we saw it” or because the described event did happen. Taken together, this indicates a ‘realist’ interpretation of the target sentences – that is, these children judged Mary’s see statements as “right” because the complement gave an accurate description of the event. The remaining children (n = 3) and one adult were at chance for the Inference sentences in the See Evidence condition (M = 0.54), suggesting uncertainty about their meaning (Figure 4, Cluster 5). Children’s responses (across all clusters) were not predicted by age (β = 0.05, SE = 0.18, p > 0.05). 0 1692 W3187459815.pdf 8 1 separator 0.9970726 ¶ 1694 1696 W3187459815.pdf 8 2 caption 0.90562975 Figure 4. Mean proportions of correct responses for target sentences in Experiment 2, grouped by response pattern. Cluster 1: Predicted Adult 1697 1841 W3187459815.pdf 8 3 table 0.97938335 "Cluster 2: Alternative Adult Cluster 3: see that 1InferenceCluster 4: RealistCluster 5: OtherAdult=9 Child=1Adult=3 Child=0 See Event See EvidenceDoesn't See See Event See EvidenceDoesn't See0.000.250.500.751.00 Visual Access ConditionMean Proportion Correct per ClusterDirect Perception InferenceAdult=9 Child=1Adult=3 Child=0 See Event See EvidenceDoesn't See See Event See EvidenceDoesn't See0.000.250.500.751.00 Visual Access ConditionMean Proportion Correct per ClusterDirect Perception InferenceTarget SentenceDirect Perception “I saw...”Inference “I saw that...”Adult PatternsChild PatternsCorrect Responses by ClusterAdult=9 Child=1Adult=3 Child=0 See Event See Evidence Doesn't See See Event See Evidence Doesn't See0.000.250.500.751.00 Visual Access ConditionMean Proportion Correct per ClusterDirect Perception Inference Adult=1 Child=7Adult=0 Child=12Adult=1 Child=3 See Event See Evidence Doesn't See See Event See Evidence Doesn't See See Event See Evidence Doesn't See0.000.250.500.751.00" 1841 2871 W3187459815.pdf 8 4 separator 0.6854675 ¶ 2871 2873 W3187459815.pdf 8 5 table 0.7814158 Visual Access ConditionMean Proportion Correct per ClusterDirect Perception InferenceP 2873 2960 W3187459815.pdf 8 6 paratext 0.33430544 roceedings 2960 2970 W3187459815.pdf 8 7 bibliography 0.3443488 of 2970 2973 W3187459815.pdf 8 8 table 0.27193224 2973 2974 W3187459815.pdf 8 9 paratext 0.45195723 ELM 1: 125-135, 2021 2974 2994 W3187459815.pdf 8 10 separator 0.99144757 ¶ 2994 2996 W3187459815.pdf 8 11 bibliography 0.5817053 E. Emory Davis and Barbara Landau 2996 3030 W3187459815.pdf 8 12 paratext 0.47028574 : 3030 3031 W3187459815.pdf 8 13 separator 0.9092944 ¶ 3031 3033 W3187459815.pdf 8 14 bibliography 0.6674227 Seeing vs. Seeing That: Children’s Understanding of Direct Perception and Inference 3033 3117 W3187459815.pdf 8 15 paratext 0.6223572 Reports. 133 3117 3130 W3187459815.pdf 8 0 title 0.89752597 BRIEFINGS 0 9 W2131601720.pdf 1 1 separator 0.995304 ¶ 9 11 W2131601720.pdf 1 2 text 0.99951345 "DrJameel isthedirector ofhospital services for the north-west region and himself apsy chiatrist, being one ofthree inthecountry. His story was ofapsychiatric service, previously cen tralised onBhagdad, which had been leftwithout in-patient resources other than beds inamedical ward. The extended family network, which might have cared formany ofhispatients, had beenwrecked bythepopulation shake-up. Hehoped todevelop atreatment and rehabilitation unit but hiswhole service was short ofthecurrency oftreatment, particularly medication including antidepressants, depot neuroleptics and anti- epileptics. The lack ofdrugs meant that ECT, with anuncertain machine, was unmodified. Although drugs were available ontheblack-market forthose who had themoney, they were ofuncer tain origin and efficacy. The shortage extended tothewhole medical service which lacked anti biotics, dressings and hospital clothing and equipment. They were dependent ondonations forjournals and books and transport was acon stant problem. There were fewdoctors and many patients; clinics were long and thetime foras sessment brief. Allthis made itadispiriting struggle tomaintain aservice, letalone develop it.And yet, intheteeth ofthis and with some outside help, theservice was being restored." 11 1330 W2131601720.pdf 1 3 separator 0.9246026 ¶ 1330 1332 W2131601720.pdf 1 4 text 0.99891955 "Throughout theday and into thelate evening patients arrived and silently queued until seen." 1332 1426 W2131601720.pdf 1 5 separator 0.5647454 ¶ 1426 1428 W2131601720.pdf 1 6 text 0.9995503 "Fortunately only aminority were formeaspsychiatric assessment was time-consuming; aslow exploration ofthe mental state notjust ofan individual but ofthefamily and their society." 1428 1610 W2131601720.pdf 1 7 separator 0.9679552 ¶ 1610 1612 W2131601720.pdf 1 8 text 0.999627 "Psychosis, neurosis and marital and family prob lems were given acultural twist. How does a transsexual even start toaddress aproblem which isanathema toboth his family and society? How does afamily continue tocare fora father who issuspected ofmurdering their mother? Forbearance and aresort toreligionwere frequent. For many the account started with the Iraqi invasion, being shelled and the subsequent move either tothecamps, into the mountains oracross theborder. Although inter marriage ledtolurid family trees ofdisturbance, onmore careful enquiry Ifound that itwas unusual foradisorder tobreed true. The preva lence ofdisturbance might simply beameasure ofthedegree and nature offamilial resilience to thehigh levels ofstress. Wediscussed thepossi bility ofsetting upaformal, trained counselling service, and whether the clergy might develop their pastoral role. The recurrent question through the discussions was that ofthelong- term consequence?" 1612 2607 W2131601720.pdf 1 9 separator 0.9646625 ¶ 2607 2609 W2131601720.pdf 1 10 text 0.99946123 "The distance and thestate oftheroads meant a full day was needed foravisit tothecapital, Arbil. Wemet MrJauhir Namiq, theHead ofthe National Assembly, who was courteous, patient and phlegmatic. The government was beginning togain some grasp oftheextent and theimpact oftorture onapopulation ofwhich about 180,000 were immediately affected by the invasion: hespoke ofthe need forasound appraisal asapreliminary torehabilitation: his request foroutside advice was passed tothe College." 2609 3115 W2131601720.pdf 1 11 separator 0.8632854 ¶ 3115 3117 W2131601720.pdf 1 12 text 0.99917096 "Ileftwith agreater appreciation ofhow fara rural community, with anextended family net work, can contain unhappiness and weather it; oftheimportance ofmedication tomodern psy chiatry; and ofwhat aluxury itistohave thetime tocarry outanywork with patients." 3117 3383 W2131601720.pdf 1 13 separator 0.97159123 ¶ 3383 3385 W2131601720.pdf 1 14 text 0.94545907 "Ifyou have any modern books, journals, drugs orequipment todonate, Kurdish Life Aid will ensure their delivery. You can" 3385 3509 W2131601720.pdf 1 15 contact 0.53410065 contact MrsBer 3509 3524 W2131601720.pdf 1 16 text 0.58175135 ney 3524 3527 W2131601720.pdf 1 17 contact 0.6765679 athome byphone 091-281-2608. 3527 3556 W2131601720.pdf 1 18 separator 0.9717877 ¶ 3556 3558 W2131601720.pdf 1 19 contact 0.97813344 "T.P.Berney, Consultant Psychiatrist, Pmdhoe Hospital, Pmdhoe. Northumberland NE42 5NT" 3558 3646 W2131601720.pdf 1 20 separator 0.41241148 3646 3647 W2131601720.pdf 1 21 paratext 0.8439845 ¶ Psychiatry inKurdistan 105 3647 3675 W2131601720.pdf 1 22 separator 0.558022 ¶ 3675 3677 W2131601720.pdf 1 23 paratext 0.9866747 https://doi.org/10.1192/pb.18.2.104 Published online by Cambridge University Press 3677 3761 W2131601720.pdf 1 0 title 0.99152553 4. How are JAs biosynthesized? 0 30 W2523255059.pdf 1 1 separator 0.996153 ¶ 30 32 W2523255059.pdf 1 2 text 0.9996007 "The JA biosynthetic pathway, also called the octadeca- noids pathway (the starting point is the 18 C fatty acid α- linolenic acid 18:3 ( α-LA)), takes place in three subcellular compartments: first in the chloroplast, then the peroxi- some, and finally the cytoplasm (Fig. 1). The very first step consists in the release of α-LA from galacto- and phos- pholipids localized at the chloroplast membrane by the action of phospholipases (PLAs), which include DEFECT- IVE IN ANTHER DEHISCENCE 1 (DAD1) in A. thaliana [23]. Subsequently, the oxidation of the polyunsaturated fatty acids α-LA by 13-LIPOXYGENASE (LOX) leads to 13-hydroperoxy-9,11,15-octadecatrienoicacid (13-HPOT) [24–26]. Two different enzyme families, termed ALLENE OXYDE SYNTHASE (AOS) and ALLENE OXYDE CY- CLASE (AOC), successively convert 13-HPOT into the stable cis(+)-oxophytodienoic acid (cis-OPDA) intermedi- ate [27 –30]. The next steps of JA biosynthesis take place in the peroxisome. How cis-OPDA is addressed to this subcellular compartment is largely unknown. So far, only one gene, COMATOSE, a peroxisome-localized protein of the ATP binding cassette (ABC) transporter class, has been linked with JA transport to this subcellular compart- ment [31, 32]. However, as loss of function mutants (inArabidopsis ) can still make some JA, there are most likely other transporters involved. In the peroxisome, cis-OPDA is reduced by an OPDA REDUCTASE (OPR) and then undergoes three rounds of β-oxydation by ACYL-CoA OXIDASE (ACX) enzymes leading to the production of jasmonic acid (JA) [33, 34]. JA is then exported though an unknown route to the cytoplasm where it can be modified by several enzymes (reviewed in [2]). The best described belongs to the class of GRETCHEN HAGEN 3 s (GH3s), which conjugates JA with vari- ous amino acids but most notably isoleucine, leading to the bioactive JA-Ile molecule [1, 35]." 32 1981 W2523255059.pdf 1 3 separator 0.99725235 ¶ 1981 1983 W2523255059.pdf 1 4 title 0.9919062 5. How is JA-Ile perceived by cells? 1983 2020 W2523255059.pdf 1 5 separator 0.9951256 ¶ 2020 2022 W2523255059.pdf 1 6 text 0.9993809 "How plant cells sense JA-Ile has been well documented and is mechanistically very similar to auxin signaling (similarities are reviewed in [36]; Fig. 2). JA-Ile acts as a molecular glue between its co-receptors COI1, an F-BOX E3 LIGASE protein, and JASMONATE ZIM DO- MAIN (JAZ) proteins, which act as transcriptional repressors [21, 37, 38]. Most JAZ proteins share two con- served regions: a ZIM domain and a Jas motif [39]. While the ZIM domain mediates protein –protein interactions that regulate JA signal transduction, the Jas motif is involved in ¶" 2022 2595 W2523255059.pdf 1 7 caption 0.9811636 "Fig. 1. Biosynthesis of JAs and different types of bioactive JAs. Biosynthesis of JAs takes place in three different cellular compartments (chloroplast, peroxisome, and cytoplasm). Refer to Question 4 for further details. Coronatine ( COR) is not synthesized by plants but by the bacteria Pseudomonas syringae (refer to Question 1 for details)Larrieu and Vernoux BMC Biology (2016) 14:" 2595 2986 W2523255059.pdf 1 8 paratext 0.89059675 79 Page 2 of 8 2986 3000 W2523255059.pdf 1 0 paratext 0.8843818 ¶ P56 1 6 W3109203219.pdf 9 1 separator 0.9311739 ¶ ¶ 6 12 W3109203219.pdf 9 2 bibliography 0.9977443 "21. J. Sen, A. B. Das Chaudhuri , Brief communication: Choice of washing method of hair samples for trace element analysis in environmental studies, Am. J. Phys. Anthropol . 115 (2001) 289–291, doi: https://doi.org/10.1002/ajpa.1083." 12 255 W3109203219.pdf 9 3 separator 0.95971733 ¶ 257 259 W3109203219.pdf 9 4 bibliography 0.99800265 "22. R. Luo, S. Zhang , P. Xiang , B. Shen, X. Zhuo , D. Ma , Elements concentrations in the scalp hair of methamphetamine abusers, Forensic Sci. Int. 249 (2015) 112 –115, doi: https://doi.org/10.1016/j.forsciint.2015.01.016." 259 493 W3109203219.pdf 9 5 separator 0.9597208 ¶ 495 497 W3109203219.pdf 9 6 bibliography 0.99767804 "23. H. I. Afridi , T. G. Kazi, M. K. Jamali , G. H. Kazi, M. B. Arain , N. Jalbani , G. Q. Shar, Analysis of heavy metals in scalp hair samples of hypertensive patients by conventional and microwave digestion methods. Spectrosc. Lett. 39 (2006) 203 –214, doi: https://doi.org/10.1080/00387010500531266." 497 819 W3109203219.pdf 9 7 separator 0.94548607 ¶ 821 823 W3109203219.pdf 9 8 bibliography 0.9978458 "24. M. F. H. Carneiro, M. B. Moresco, G. R. Chagas , V. C. de Oliveira Souza, C. R. Rhoden, F. Barbosa, Assessment of trace elements in scalp hair of a young urban population in Brazil, Biol. Trace Elem. Res. 143 (2011) 815 –824, doi: https://doi.org/10.1007/s12011 -010-8947 -z." 823 1116 W3109203219.pdf 9 9 separator 0.9341259 ¶ 1117 1119 W3109203219.pdf 9 10 bibliography 0.99779016 "25. M. Matsumoto , J. Yoshinaga , Isotope ratios of lead in Japanese women's hair of the twentieth century, Environ. Sci. Pollut. Res. 17 (2010) 643 –649, doi: https://doi.org/10.1007/s11356 -009-0255 -9." 1119 1335 W3109203219.pdf 9 11 separator 0.9429083 ¶ 1336 1338 W3109203219.pdf 9 12 bibliography 0.9977375 "26. P. Trojanowski , J. Trojanowski , J. Antonowicz , M. Bokiniec , Lead and cadmium content in human hair in Central Pomerania (Northern Poland), J. Elementol . 15 (2010) 363 – 384, doi: https://doi.org/10.5601/jelem.2010.15.2.363 -384. 27. H. Nasser , Trace element levels in nape of neck hair from local population Latakia – Syria: link to sex and age factor s, Int. J. Chem. Stud . 1 (2014) 27 –35." 1338 1756 W3109203219.pdf 9 13 separator 0.9553515 ¶ 1757 1759 W3109203219.pdf 9 14 bibliography 0.9977446 "28. G. Liang , L. Pan, X. Liu, Assessment of typical heavy metals in human hair of different age groups and foodstuffs in Beijing, China, Int. J. Environ. Res. Public Health 14 (2017) 914, doi: https://doi.org/10.3390/ijerph14080914." 1759 2003 W3109203219.pdf 9 15 separator 0.932178 ¶ 2005 2007 W3109203219.pdf 9 16 bibliography 0.9978497 "29. Z. Li, Q. Wang , Y. Luo, Exposure of the urban population to mercury in Changchun city, Northeast China, Environ. Geochem. Health 28 (2006) 61 –66, doi: https://doi.org/ 10.1007/s10653 -005-9012 -2." 2007 2220 W3109203219.pdf 9 17 separator 0.95970476 ¶ 2221 2223 W3109203219.pdf 9 18 bibliography 0.99763596 "30. J. C. Raposo , P. Navarro, A. Sarmiento , E. Arribas , M. Irazola , R. M. Alonso , Analytical proposal for trace element determination in human hair. Application to the Biscay province population, northern Spain , Microchem. J. 116 (2014) 125 –134, doi: https://doi.org/10.1016/j. microc.2014.04.012." 2223 2547 W3109203219.pdf 9 19 separator 0.9699872 ¶ 2549 2551 W3109203219.pdf 9 20 bibliography 0.99796647 "31. H. Mikasa , Y. Suzuki , N. Fujii, K Nishiyama, Adsorption and elution of metals on hair, Biol. Trace Elem. Res. 16 (1988) 59 – 66, doi: https://doi.org/10.1007/BF02795334." 2551 2733 W3109203219.pdf 9 21 separator 0.9554902 ¶ 2735 2737 W3109203219.pdf 9 22 bibliography 0.9977607 "32. P. Borella , S. Rovesti , E. Caselgrandi , A. Bargellini , Quality control in hair analysis: A systematic study on washing procedures for trace element determinations, Mikrochim. Acta 123 (1996) 271 –280, doi: https://doi.org/10.1007/bf01244400." 2737 3001 W3109203219.pdf 9 23 separator 0.9507674 "¶ ¶ ¶" 3003 3021 W3109203219.pdf 9 24 text 0.99917233 "Ljudska kosa je biološki uzorak koji se, za razliku od krvi, skuplja neinvazivno i može rabiti u procjeni unosa elemenata. Prije analize uzorke kose potrebno je oprati kako bi se odstranila vanjska onečišćenja za što ne postoje standardni postupci. Istraživanjem je procijenjena učinkovitost različit ih postupaka pranja uzoraka kose (neionskim detergentom, kiselinama, otapalima i njihovim mješavinama) uključujući primjenu ultrazvuka prije analize elemenata (As, Ca, Cd, Cu, Fe, Hg, Mg, Mn, Mo, Pb, Se, and Zn) metodom ICP -MS. Ispitivani postupci pranja b ili su zadovoljavajući, izuzev primjenom dušične i klorovodične kiseline, pri čemu se elementi “otpuštaju” i gube zbog oštećivanja kose (vidljive su promjena boje i pucanje vlasi). Primjena ultrazvuka pospješila je učinkovitost pranja uzoraka do 10 % ovisn o o ispitivanom elementu i postupku pranja." 3021 3902 W3109203219.pdf 9 25 separator 0.9960054 ¶ 3904 3906 W3109203219.pdf 9 26 title 0.86624104 Uzorak ljudske kose, učinkovitost postupka pranja, analiza metala, endogeni i egzogeni elementi 3906 4002 W3109203219.pdf 9 27 separator 0.9863242 ¶ ¶ 4004 4010 W3109203219.pdf 9 28 contact 0.83627015 "Institut za medicinska istraživanja i medicinu rada Ksaverska cesta 2 10 000 Zagreb, Hrvatska" 4010 4112 W3109203219.pdf 9 29 separator 0.8524548 ¶ 4115 4117 W3109203219.pdf 9 30 title 0.5937445 Izvorni znanstveni 4117 4136 W3109203219.pdf 9 31 paratext 0.48818558 rad 4136 4140 W3109203219.pdf 9 32 separator 0.72978544 ¶ 4142 4144 W3109203219.pdf 9 33 paratext 0.87691295 "Prispjelo 28. svibnja 2020. Prihvaćeno 18. srpnja 2020." 4144 4206 W3109203219.pdf 9 34 separator 0.9956214 ¶ 4208 4210 W3109203219.pdf 9 0 paratext 0.9753519 "2 Vol:.(1234567890) Scientific Reports | (2023) 13:20713 | https://doi.org/10.1038/s41598-023-47935-7" 0 112 W4388967905.pdf 1 1 separator 0.9744877 ¶ 112 114 W4388967905.pdf 1 2 text 0.99588054 "www.nature.com/scientificreports/using multivariate Cox model over some clinical features and reported a combination of age, ALS Functional Rating Scale-Revised (ALSFRS-R) score, and body mass index factors are relevant to survival. The ALS-SS system produces a risk score for each patient (which can be used to predict which patient will die first) but does not provide the expected length of survival itself. Many studies formulate the survival prediction task as a binary classification for a single time point, such as surviving one year or two years. Schuster et al.6 logistic ridge regres- sion model used clinical and/or MRI features to predict 18-month survival, with prediction accuracy of 66.67% from clinical features, 77.08% from MRI features and 79.17% from both. Pfohl et al.7 learned generalized linear and random forest models over 38 clinical features to classify survival at different time points, starting from 30 days to 5 years. Another study successfully applied the non-linear dimension reduction technique, Uniform Manifold Approximation and Projection (UMAP)8, for 1-year survival analysis in ALS and claimed to achieve 94% accuracy9. Introna et al.10 investigated whether the slope of the King’s College ALS clinical staging (KC) system11 at the initial visit could predict survival in a cohort of ALS patients; they found the KC progression rate ( /Delta1KC) demonstrated an accuracy of 92%, 85%, and 83% in predicting survival at one year, two years, and three years, respectively. Overall, the performance for single time point prediction is promising for some specific time points. However, those studies appear to ignore censored individuals (defined in the next section), which can be a large proportion. Also, the time points being predicted varies for different studies. Our individual survival curve model (described in the next section) provides survival probability for all future time points, and also explicitly deals with censored patients." 114 2147 W4388967905.pdf 1 3 separator 0.9886081 ¶ 2147 2149 W4388967905.pdf 1 4 text 0.99977475 "Some studies predict the survival time by describing the task as classifying event occurrence into multiple time windows. Van der Burgh et al.12 applied a deep neural network to eight clinical features, along with some imaging features from diffusion-weighted and T1-weighted MR images, to produce a model that could classify ALS patients as short, medium or long survivors. They found that just using those eight clinical features (or just the MRI characteristics) could not achieve robust performance, but the combined features obtained 84.4% classification accuracy. Corrado et al.13 proposed machine learning methods capable of addressing competing risks and censoring for the Intelligent Disease Progression Prediction (IDPP) challenge dataset.14 These ML techniques produce an average C-index of around 0.70 and 0.74, utilizing data from the first visit and 6 months later, respectively, to predict competing risks such as non-invasive ventilation (NIV), percutaneous endoscopic gastrostomy (PEG) and death. They report 0.86 specificity but low sensitivity for predicting the time of event occurrence. Although knowing the event time window can help us narrow down the estimated event time, the size of the time window might not meet the needs of clinicians (e.g., van der Burgh et al.12 use only three time windows). Also, if the data has censored instances, any model that does not handle censoring (e.g., the model used by van der Burgh et al.12) might introduce bias. In our approach, the learned model predicts the individual survival curves. Westeneng et al.15 use the multivariable Royston-Parmar survival model (Royston et al.16) to predict individual survival curves and report a C-index of 0.78. However, they did not report any event time prediction error measurement." 2149 3983 W4388967905.pdf 1 5 separator 0.98849386 ¶ 3983 3985 W4388967905.pdf 1 6 text 0.99968565 "The papers above describe various approaches to survival prediction—e.g., produce a risk score, or a 1-year survival probability, etc. While useful for some tasks, we note that none actually estimates how long a person will survive. Below we provide a way to produce such personalized estimates. As our goal is a model that minimizes the difference between predicted time and true survival time, we therefore evaluate proposed models by their mean absolute error (MAE-Margin; see section “ MAE-margin ”) based on predicted median survival times. (Note that it is possible that a model could have a good C-index, but a bad MAE-Margin, and vice versa; similarly for 1-year survival probability vs MAE-Margin; etc.17)" 3985 4718 W4388967905.pdf 1 7 separator 0.99365044 ¶ 4718 4720 W4388967905.pdf 1 8 title 0.9833929 Personalized survival prediction 4720 4753 W4388967905.pdf 1 9 separator 0.99393153 ¶ 4753 4755 W4388967905.pdf 1 10 text 0.99965626 We view survival prediction as learning a model that can estimate the time until an event, for each individual. 4755 4867 W4388967905.pdf 1 11 separator 0.5560006 4868 4869 W4388967905.pdf 1 12 text 0.9981581 "¶ This “time to an event” task resembles regression - given a description of a patient, predict a non-negative real value (his/her time to death). Learning a survival model is more complicated, as the training data typically includes censored training instances, which provide only a lower bound on the survival time. (For example, imagine a patient left the study after 220 days and is then lost to follow-up. We know this patient lived for at least 220 days, but we do not know whether she lived 221 or 1000 days or 30 years.) As 45% of the patients in our data are censored, it is important that the process for learning our survival prediction models incorporates these censored training instances to avoid bias19; note our evaluation must also deal with such censored labels." 4869 5668 W4388967905.pdf 1 13 separator 0.95860183 ¶ 5669 5671 W4388967905.pdf 1 14 text 0.99927044 The field of survival prediction (i.e., survival analysis) deals with this kind of censored data. 5671 5769 W4388967905.pdf 1 15 separator 0.9656224 ¶ 5769 5771 W4388967905.pdf 1 16 text 0.99957263 "A single time-point binary classification (e.g., the probability that a patient will die before 100 days) might not be enough to tell the full story of a patient’s survival. A more recent approach provides an “individual sur - vival distribution” (ISD)20 for each patient, which is a survival probability for all future times (i.e., a survival distribution) specific to this individual; see Fig. 1. The survival curve for a patient provides the probability that this patient will live until at least time t (i.e., survival probability) at each future time point t≥0 . For example, the model shown in Fig. 1 predicts that patient A has a 90% probability of living at least t=20.7 months and 50% probability of living at least t=40.4 months, etc. We also see that this model makes different predictions for Patients A, B, and C." 5771 6621 W4388967905.pdf 1 17 separator 0.97196686 ¶ 6621 6623 W4388967905.pdf 1 18 text 0.99966353 "Here, we consider the time until the composite respiratory failure event occurs: death, tracheostomy, or use of non-invasive ventilation for more than 23 hours per day. The composite respiratory failure, which is related to the use of surrogates to sustain survival, is widely used in ALS survival research.10,15,21 We develop a SuperLearner that learns a model that can predict ISDs for each ALS patient using the patient’s clinical information and cortical thickness extracted from the patient’s MR image. The SuperLearner selects the best survival prediction models from several candidates to provide predictions. Our SuperLearner aims to achieve the best MAE-margin (mean" 6623 7314 W4388967905.pdf 1 0 paratext 0.9887133 P. OREKHOVSKY. Federalism. 2019. N 2. P. 61–71 69 0 50 W3006372113.pdf 8 1 separator 0.99239784 ¶ 50 52 W3006372113.pdf 8 2 text 0.99888 "но жесткое централизованное регулирование, единую внешнеторговую, финансовую и миграционную политику. Напротив, ситуация, когда каждое государство осуществляет регулирование, исходя из собственных интересов, не находясь под патронажем США или Брюсселя, позволяет найти ему с Россией общий язык." 52 350 W3006372113.pdf 8 3 separator 0.9462992 ¶ 351 353 W3006372113.pdf 8 4 text 0.9993165 "Также становится понятно, почему у России часто возникают выгод- ные альянсы с экономиками со средним уровнем дохода, правительства которых придерживаются «левой» ориентации. Последняя предполагает осуществление индустриализации и «первичной» модернизации, ко-торая, как правило, осуществляется авторитарными и популисткими политическими режимами. В отличие от западных стран, которые с мессианской убежденностью пытаются экспортировать институты либеральной демократии, российские компании, как и российские по-литики, готовы принимать и понимать «местную специфику» . Как только какое-либо из государств по той или иной причине выпадает из иерар-хической организации «однополярного мира» (а в случае стран с прави-тельствами левой ориентации это случается достаточно часто), сразу же возникает возможность взаимовыгодных торгово-финансовых альянсов с капиталистической Россией." 353 1238 W3006372113.pdf 8 5 separator 0.98421264 ¶ 1239 1241 W3006372113.pdf 8 6 text 0.9946584 "Как было показано выше, концепция регрессивной модернизации не является специфическим российским открытием. Однако, допол-ненные компонентами традиционализма и патернализма, институ-ты регрессивной модернизации в настоящее время являются основными «статьями» российского институционального экспорта . Взаимодействие конфессий под патронажем государства, «имперское» федеративное устройство, допускающее наличие культурно-национальных автономий, государственный патернализм, тесно переплетающийся с крупным биз-несом в рамках частно-государственного партнерства — вся эта россий-ская институциональная среда хорошо приживается и на восточно-ази-атской, и на ближневосточной, и на латиноамериканской почве. Старые советские элементы дирижизма, которые также воплощаются в практике «ручного управления» и персональной ответственности государствен-ных чиновников за развитие частного бизнеса — элементы российского институционального дизайна, который, как это ни странно, находит применение даже в некоторых богатых западных странах (при этом, однако, респектабельно ссылаться на Ф. Листа, камералистику и не-омеркантилизм). * * *" 1241 2380 W3006372113.pdf 8 7 separator 0.98965496 ¶ 2380 2382 W3006372113.pdf 8 8 text 0.9925942 "На пути российск о го институци о нальн о го э ксп орта есть сво и ограничения. Широко известными слабостями российской инсти- туциональной модели являются, во-первых, недостаточная полно- та и юридическая проработанность формальных контрактов, опора на традиции и доверие. Во-вторых, сравнительная «рыхлость» судебной системы и хозяй- ственного законодательства, позволяющая трансформировать админи- стративные и экономические конфликты в уголовные." 2382 2853 W3006372113.pdf 8 0 paratext 0.9852408 Page 8 of 9 Cao et al. BMC Neurology (2022) 22:452 0 59 W4311281976.pdf 7 1 separator 0.9875485 ¶ 60 62 W4311281976.pdf 7 2 title 0.9679468 Availability of data and materials 62 97 W4311281976.pdf 7 3 separator 0.9766356 ¶ 97 99 W4311281976.pdf 7 4 text 0.9649844 "The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request." 99 228 W4311281976.pdf 7 5 separator 0.9951682 ¶ 228 230 W4311281976.pdf 7 6 title 0.9646043 Declarations 230 243 W4311281976.pdf 7 7 separator 0.985345 ¶ 243 245 W4311281976.pdf 7 8 title 0.9612236 Ethics approval and consent to participate 245 288 W4311281976.pdf 7 9 separator 0.96543515 ¶ 288 290 W4311281976.pdf 7 10 text 0.99115235 "Informed consents were obtained from the participants entering the stroke registry, and this analysis was approved by the Ethics Committee of Changzhou Second People’s Hospital Affiliated to Nanjing Medical University (Approval No: [2018]KY032-01). All methods were conducted in accordance with the ethical standards of the declaration of Helsinki." 290 651 W4311281976.pdf 7 11 separator 0.99442995 ¶ 651 653 W4311281976.pdf 7 12 title 0.76464415 Consent for publication 653 677 W4311281976.pdf 7 13 separator 0.9326013 ¶ 677 679 W4311281976.pdf 7 14 paratext 0.59327894 Not 679 683 W4311281976.pdf 7 15 text 0.59497845 applicable. 683 695 W4311281976.pdf 7 16 separator 0.9936033 ¶ 695 697 W4311281976.pdf 7 17 title 0.8963731 Competing interests 697 717 W4311281976.pdf 7 18 separator 0.9671279 ¶ 717 719 W4311281976.pdf 7 19 text 0.84630924 The authors declare that they have no competing interests. 719 778 W4311281976.pdf 7 20 separator 0.9926392 ¶ 778 780 W4311281976.pdf 7 21 title 0.5983209 Author details 780 795 W4311281976.pdf 7 22 separator 0.9873289 ¶ 795 797 W4311281976.pdf 7 23 contact 0.8730783 "1 Department of Neurology, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, 213003 Changzhou, China. 2 Depart - ment of Neurosurgery, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, No.29, Xinglong Lane, Jiangsu 213003 Chang- zhou, China." 797 1123 W4311281976.pdf 7 24 separator 0.9295111 ¶ 1124 1126 W4311281976.pdf 7 25 paratext 0.97696656 Received: 24 July 2022 Accepted: 18 November 2022 1126 1178 W4311281976.pdf 7 26 separator 0.988111 ¶ 1178 1180 W4311281976.pdf 7 27 title 0.5792599 References 1180 1191 W4311281976.pdf 7 28 separator 0.9716948 ¶ 1191 1193 W4311281976.pdf 7 29 bibliography 0.99805766 "1. 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Standards for Detecting, Interpreting, and reporting noncontrast computed tomographic markers of Intracerebral Hemorrhage Expansion. Ann Neurol. 2019;86(4):480–92." 2450 2732 W4311281976.pdf 7 42 separator 0.93678206 ¶ 2732 2734 W4311281976.pdf 7 43 bibliography 0.99805325 "8. Wada R, Aviv RI, Fox AJ, Sahlas DJ, Gladstone DJ, Tomlinson G, Symons SP . CT angiography “spot sign” predicts hematoma expansion in acute intracerebral hemorrhage. Stroke. 2007;38(4):1257–62." 2735 2937 W4311281976.pdf 7 44 separator 0.91302425 ¶ 2937 2939 W4311281976.pdf 7 45 bibliography 0.9979589 "9. Broderick JP , Diringer MN, Hill MD, Brun NC, Mayer SA, Steiner T, Skolnick BE, Davis SM. Determinants of intracerebral hemorrhage growth: an exploratory analysis. Stroke. 2007;38(3):1072–5." 2940 3140 W4311281976.pdf 7 46 separator 0.9221568 ¶ 3140 3142 W4311281976.pdf 7 47 bibliography 0.9977238 "10. Li Q, Zhang G, Huang YJ, Dong MX, Lv FJ, Wei X, Chen JJ, Zhang LJ, Qin XY, Xie P . 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Ma Z, Chen X, Huang Y, He L, Liang C, Liang C, Liu Z. MR diffusion- weighted imaging-based subcutaneous tumour volumetry in a xeno - grafted nude mouse model using 3D slicer: an accurate and repeatable method. Sci Rep. 2015;5:15653." 7912 8156 W4311281976.pdf 7 88 separator 0.96065474 ¶ 8156 8158 W4311281976.pdf 7 89 bibliography 0.99807334 "32. Egger J, Kapur T, Fedorov A, Pieper S, Miller JV, Veeraraghavan H, Freisle - ben B, Golby AJ, Nimsky C, Kikinis R. GBM volumetry using the 3D slicer medical image computing platform. Sci Rep. 2013;3:1364." 8159 8373 W4311281976.pdf 7 0 paratext 0.9894358 Life2023 ,13, 433 10 of 26 0 26 W4319082983.pdf 9 1 separator 0.71863973 ¶ 26 28 W4319082983.pdf 9 2 paratext 0.9795075 Life 2023 , 13, x FOR PEER REVIEW 10 of 27 28 71 W4319082983.pdf 9 3 separator 0.95586884 ¶ ¶ 72 78 W4319082983.pdf 9 4 text 0.99935067 "on chlorophyll- a in both hybrids at both sampling times. Chlorophyll- a content of Desszert 73 and Noa significantly decreased ( p < 0.05) when infected by the three corn smut concentrations (87%, 127%, and 146% in Desszert 73, and 79%, 75%, and 106% in Noa) at 7 DAPI compared to the control plan ts. At the second sampling time (14 DAPI), the reductions were 254%, 286%, and 316% for Desszert 73 and 127%, 160%, and 167% for Noa, respectively. Noa had the most significant reduction when the highest sporidium treatment was applied (means for at 7 and 14 DAPI at 10,000 sporidia/mL followed by different letters) (Figure 3A)." 79 726 W4319082983.pdf 9 5 separator 0.9453094 ¶ 728 730 W4319082983.pdf 9 6 text 0.99933594 "Corn smut infection also had negative effects on the amounts of chlorophyll- b in the Desszert 73 and Noa hybrids ( p < 0.05). Increased concentration of sporidia diminished chlorophyll- b by 46%, 89%, and 116% in Desszert 73 and 63%, 107%, and 121% in Noa compared to the control plants at 7 DAPI. Furthermore, the reduction was 76%, 108%, and 127% in Desszert 73 and 170%, 214%, and 244% in Noa hybrids at 14 DAPI (Figure 3B)." 730 1171 W4319082983.pdf 9 7 separator 0.96524304 ¶ 1172 1174 W4319082983.pdf 9 8 text 0.99775535 "The carotenoid content was reduced at 7 DAPI by 40% ( p = 0.016) and 123% ( p = 0.006) in the Desszert 73 and Noa hybrids treated 5000 sporidia/mL; 49% ( p = 0.023) and 185% ( p = 0.006) in Desszert 73 and Noa hybrids treated with 10,000 sporidia/mL. Similarly, at 14 DAPI, carotenoid content was also signific antly reduced under 2500, 5000, and 10,000 sporidia/mL in Desszert 73 [53% ( p = 0.013), 222% ( p = 0.005), and 216% ( p= 0.004)] and Noa [380% ( p = 0.000), 203% ( p = 0.030), and 450% ( p = 0.000] (Figure 3C)." 1174 1709 W4319082983.pdf 9 9 separator 0.5968903 ¶ 1710 1712 W4319082983.pdf 9 10 text 0.5005268 1714 1715 W4319082983.pdf 9 11 separator 0.8152518 ¶ ¶ 1715 1720 W4319082983.pdf 9 12 paratext 0.98355186 Life 2023 , 13, x FOR PEER REVIEW 11 of 27 1720 1763 W4319082983.pdf 9 13 separator 0.88795185 "¶ ¶" 1764 1775 W4319082983.pdf 9 14 caption 0.9962297 Figure 3. (A) The effects of corn smut infection on chlorophyll- a (mg g−1 FW) (mean ± SD, n = 5), ( B) 1775 1879 W4319082983.pdf 9 15 separator 0.9596652 ¶ 1880 1882 W4319082983.pdf 9 16 caption 0.5943541 The effects of corn 1882 1902 W4319082983.pdf 9 17 text 0.52253 smut 1902 1907 W4319082983.pdf 9 18 caption 0.46436897 1907 1908 W4319082983.pdf 9 19 text 0.87361825 "infection on chlorophyll- b (mg g−1 FW) (mean ± SD, n = 5), ( C) The effects of corn smut infection on carotenoids (mg g−1 FW) (mean ± SD, n = 5) of the fourth leaves of Desszert 73 and Noa hybrids at 7 and 14 DAPI. The data were evaluated by one-way ANOVA followed by the Tukey-HSD test at 0.05 to determine significant differences indicated by different letters (a, b, c, d, and e)." 1908 2301 W4319082983.pdf 9 20 caption 0.7516669 DAPI: days after the pathogen infection, FW: fresh weight. 2301 2360 W4319082983.pdf 9 21 separator 0.9857824 ¶ 2361 2363 W4319082983.pdf 9 22 text 0.99922353 "The respective corn smut treatm ents significantly increased ( p ≤ 0.001) the MDA content of Desszert 73 and Noa hybrids’ leaves (140%, 181%, 224% and 194%, 215%, and 280% reduction) at 7 DAPI. The MDA content was significantly ( p ≤ 0.001) increased at 14 DAPI in Desszert 73 and Noa infected with th e three concentrations of corn smut (147%, 191%, and 260% increase; 205%, 242%, and 282% in crease) in the infected plants due to the different concentration of the inoculum at 14 DAPI (Figure 4)." 2363 2878 W4319082983.pdf 9 23 separator 0.98347 ¶ ¶ 2879 2885 W4319082983.pdf 9 24 caption 0.9963725 "Figure 4. The MDA content (nmol MDA g−1 FW) of the fifth leaves of corn smut infected Desszert 73 and Noa hybrids at 7 and 14 DAPI (mean ± SD, n = 5). The data were evaluated by one-way ANOVA followed by the Tukey-HSD test at 0.05 to determine significant differences indicated by different letters (a, b, c, d, e, and f). DAPI: days after the pathogen infection. FW: fresh weight, MDA: malondialdehyde." 2885 3302 W4319082983.pdf 9 25 separator 0.98908013 ¶ 3303 3305 W4319082983.pdf 9 26 text 0.984197 "The APX activity in the leaves of Desszert 73 and Noa hybrids significantly ( p ≤ 0.001) increased with infection intensity (100%, 132%, 147%, and 67%, 96%, and 119%," 3305 3475 W4319082983.pdf 9 27 separator 0.98960483 ¶ 3476 3478 W4319082983.pdf 9 28 caption 0.99554 Figure 3. (A) The effects of corn smut infection on chlorophyll- a(mg g 3478 3550 W4319082983.pdf 9 0 paratext 0.9707108 "Al-Ijtimā’: Jurnal Pengabdian Kepada Masyarakat p-ISSN: 2746 -492X Vol. 1 No. 2 April 2021 e-ISSN : 2746 -4938 ¶ 108 ¶" 0 134 W3183149017.pdf 14 1 separator 0.7477672 ¶ ¶ 136 142 W3183149017.pdf 14 2 title 0.985826 Kelima , Deliver atau Destiny . 142 174 W3183149017.pdf 14 3 separator 0.9929245 ¶ 176 178 W3183149017.pdf 14 4 text 0.99887085 "Tahap deliver atau destiny adalah tahap di mana setiap orang dalam organisasi mengimplementasikan berbagai hal termasuk pelaksanaan dan pengontrolan atau pengevaluasian program dampingan terhadap komunitas yang sudah dirumuskan pada tahap Dream dan Design ." 178 448 W3183149017.pdf 14 5 separator 0.6177319 ¶ 449 451 W3183149017.pdf 14 6 text 0.9968843 "Didalam tahapan de livery atau destiny ini, terdapat beberapa tahapan yang akan dilakukan sebagai berikut :" 451 562 W3183149017.pdf 14 7 separator 0.97169584 ¶ ¶ 565 571 W3183149017.pdf 14 8 title 0.76270646 1. Tahap Pelaksanaan 571 592 W3183149017.pdf 14 9 text 0.9863471 ". Sebagaimana waktu kegiatan pendampingan yang telah dilakukan di taham design, maka ditemukan bahwa Pelatihan dan Pendampingan Pengengembangan Ketahanan Pangan dalam menghadapi Masa Pandemi Covid 19 dilaks anakan pada Hari Selasa tanggal 22 september 2020 jam 08:30 -selesai." 592 883 W3183149017.pdf 14 10 separator 0.97198135 ¶ 885 887 W3183149017.pdf 14 11 text 0.99698704 "Pelaksanaan tersebut berjalan dengan lancar dan sukses mulai dari pembukan, acara inti (penyampa ian materi dan praktek), dan penutup. Acara pelatihan dan pendampingan ini dipimpin oleh pembawa acara yang bernama Siti Izatul Lailiyah . Adapun susunan acaranya adalah sebagai berikut:" 887 1187 W3183149017.pdf 14 12 separator 0.9588047 ¶ 1189 1191 W3183149017.pdf 14 13 text 0.9972408 "a. Pembukaan. Acara pembukaan ini dibukan dengan pembacaan AlFatehah yang dipimping oleh pembawa acara yang bernama Siti Izatul Lailiyah ." 1191 1334 W3183149017.pdf 14 14 separator 0.9035976 ¶ 1335 1337 W3183149017.pdf 14 15 text 0.99845934 "b. Acara inti. Acara inti dimulai dengan penyampaian materi pelatihan dan pendampingan. Acara inti dipimpin langsung oleh peneliti atau pelaku pemberdayaan yaitu saya sendiri dan dibantu oleh Fauzan sebagai perwakilan komunitas. Isi materi yang disampaikan diawali deng an dengan penyampaian tentang keadaan ekonomi baik secara global maupun lokal terlebih dengan adanya Krisis di masa Pandemi Covid 19 menjadikan inflasi dan resesi di berbagai sektor ekonomi. Diperlukan adanya sikap mandiri kreatif dan inovatif dalam pengembangan produk bahan pangan yang murah dan mudah didapat." 1337 1946 W3183149017.pdf 14 16 separator 0.99521327 ¶ 1948 1950 W3183149017.pdf 14 17 caption 0.9890659 Gambar 04. 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[CrossRef]" 3501 3685 W3042276135.pdf 15 37 separator 0.81887734 ¶ 3685 3687 W3042276135.pdf 15 38 bibliography 0.9978927 "44. Carrasco, F.; Mutj é, P .; Pelach, M.A. Refining of bleached cellulosic pulps: Characterization by application of the colloidal titration technique. Wood Sci. Technol. 1996 ,30, 227–236. [CrossRef]" 3687 3890 W3042276135.pdf 15 39 separator 0.8925315 ¶ 3890 3892 W3042276135.pdf 15 40 bibliography 0.9978987 "45. Marx-Figini, M. The acid-catalyzed degradation of cellulose linters in distinct ranges of bacterial nano-cellulose reinforced fibre-cement composites. Constr. Build. Mater. 1987 ,101, 958–964." 3892 4090 W3042276135.pdf 15 41 separator 0.95020103 ¶ 4090 4092 W3042276135.pdf 15 42 bibliography 0.9979759 "46. Shinoda, R.; Saito, T.; Okita, Y.; Isogai, A. Relationship between length and degree of polymerization of TEMPO-oxidized cellulose nanofibrils. Biomacromolecules 2012 ,13, 842–849. [CrossRef]" 4092 4289 W3042276135.pdf 15 43 separator 0.8799923 ¶ 4289 4291 W3042276135.pdf 15 44 bibliography 0.9980075 "47. Segal, L.; Creely, J.J.; Martin, A.E.; Conrad, C.M. Empirical Method for Estimating the Degree of Crystallinity of Native Cellulose Using the X-Ray Di ractometer. Text Res. J. 1959 ,29, 786–794. [CrossRef]" 4291 4504 W3042276135.pdf 15 45 separator 0.9824167 ¶ 4504 4506 W3042276135.pdf 15 46 paratext 0.942933 "Sample Availability: Samples of the compounds are not available from the authors. ©2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http: //creativecommons.org /licenses /by/4.0/)." 4506 4835 W3042276135.pdf 15 0 paratext 0.98127294 12 0 2 W1986181224.pdf 5 1 separator 0.9916731 ¶ 2 4 W1986181224.pdf 5 2 text 0.9947846 "Como elementos que favoreceram esse processo de integração social, as pessoas indicaram a reabilitação pulmonar, oapoio da família e o grupo de convivência. Nesse sentido, dentre os objetivos da reabilitação pulmonar estão a redução dos sintomas, a redução da perda funcional causadapela doença pulmonar e otimização das atividades físicas e sociais, traduzidas em melhoria da qualidade de vida (16). O exercício físico, a educação do paciente e de seus familiares e a intervenção psicossocialauxiliam no alcance desses objetivos, tal como evidenciamos no grupo pesquisado." 4 592 W1986181224.pdf 5 3 separator 0.9770586 ¶ 592 594 W1986181224.pdf 5 4 text 0.99856216 "Outro elemento que contribuiu para a superação dos limites da doença e do tratamento foi a reconquista de sua autonomia, através do autocuidado, conforme pode ser percebido nos depoimentos que seguem:" 594 801 W1986181224.pdf 5 5 separator 0.7324228 ¶ 801 803 W1986181224.pdf 5 6 text 0.9896517 "O importante é ter coragem de fazer as coisas, ter confiança de fazer o que nos ensinaram, especialmente, de respirar certo nas horas que precisamos (Iara). Nós reaprendemos a caminhar... (Mara). Hoje eu já sei que posso subir uma escada, antes eu não conseguia (...) Eu aprendi a respirar e estou até ensinando aos outros como respirarmelhor e corretamente (Mara)." 803 1179 W1986181224.pdf 5 7 separator 0.96736765 ¶ 1179 1181 W1986181224.pdf 5 8 text 0.99374795 "A pessoa quando se sente incapaz de cuidar de si mesma tem afetada sua auto-estima e autoconfiança. Aprender a lidar com adoença através de modificações ou adaptações de seus hábitos, é fator essencial para que haja autonomia. " 1181 1413 W1986181224.pdf 5 9 separator 0.5627159 ¶ 1413 1414 W1986181224.pdf 5 10 text 0.9993658 "Isso demonstra a importância do processo educativo em saúde, no sentido de instrumentalizar as pessoas para viverem seu potencial máximo. Essa instrumentalização inclui meios de conservação de energia: alimentação adequada, cuidados com higiene, vestuário ereadaptação ao trabalho." 1414 1702 W1986181224.pdf 5 11 separator 0.99539137 ¶ 1702 1704 W1986181224.pdf 5 12 title 0.97826564 - Contar com o apoio da família 1704 1736 W1986181224.pdf 5 13 separator 0.9939978 ¶ 1736 1738 W1986181224.pdf 5 14 text 0.99959916 "Um importante aspecto para quem tem uma doença crônica é a dificuldade de explicar aos outros como se sentem. Algumas vezesas pessoas próximas não demonstram interesse real ou não sentem necessidade de estarem realmente envolvidas na situação. Isso, muitas vezes, tende a levar ao isolamento, como mostra o depoimento de umapessoa sobre a percepção de sua família sobre a situação:" 1738 2126 W1986181224.pdf 5 15 separator 0.7107458 ¶ 2126 2128 W1986181224.pdf 5 16 text 0.9995735 "A família acostuma com a situação e, às vezes, pensam que é manha, não acreditam... Mas a gente sempre acha que cada crise é diferenteda outra e sempre queremos que a família compreenda isso (Iara)." 2128 2329 W1986181224.pdf 5 17 separator 0.96198463 ¶ 2329 2331 W1986181224.pdf 5 18 text 0.99964046 "No entanto, a situação que mais encontramos entre os integrantes do grupo foi de receberem apoio da família, contribuindopara a superação de dificuldades e sentirem-se confortados pelos seus familiares, como pode ser observado no depoimento que segue:" 2331 2587 W1986181224.pdf 5 19 separator 0.84619784 ¶ 2587 2589 W1986181224.pdf 5 20 text 0.9981207 "Minha mãe me compreende, protege até demais...meu marido mecompreende muito, a família reanima a gente; ela não deixa eu me entregar (Flávia)." 2589 2734 W1986181224.pdf 5 21 separator 0.9663424 ¶ 2734 2736 W1986181224.pdf 5 22 text 0.99953157 "As relações familiares são consideradas como influenciando a qualidade de vida das pessoas(3,7), uma vez que poder contar com a compreensão e o respeito à suas limitações ajudará na conquista deuma vida mais harmônica. Assim, a convivência harmônica em família, a possibilidade de trocarem informações, de se conhecerem cada vez mais, foi destacada por algumas pessoas, como mostra o depoimentode Mara:" 2736 3147 W1986181224.pdf 5 23 separator 0.9055799 ¶ 3147 3149 W1986181224.pdf 5 24 text 0.99885267 "Nos reunimos meia hora por semana para discutirmos o que precisa ser mudado. Ali eu aprendo muita coisa e cada dia eu conheço um pouquinhomais minha família, a gente aprende com eles (Mara)." 3149 3342 W1986181224.pdf 5 25 separator 0.9966054 ¶ 3342 3344 W1986181224.pdf 5 26 title 0.99346113 "B) Contribuição do grupo de convivência para a melhoria da qualidade de vida" 3344 3423 W1986181224.pdf 5 27 separator 0.9933858 ¶ 3423 3425 W1986181224.pdf 5 28 text 0.99947506 "A partir da concepção que qualidade de vida inclui satisfação com domínios da vida, procuramos compreender como o grupo de convivência contribui para melhorar a qualidade de vida das pessoas que dele participaram." 3425 3645 W1986181224.pdf 5 29 separator 0.5534407 ¶ 3645 3647 W1986181224.pdf 5 30 text 0.99948287 "Foram discutidos diferentes temas no grupo, que teve como princípios orientadores de seu desenvolvimento: - promoção da livre expressão de idéias; - respeito pelos saberes e experiências de cadaum; - estímulo e participação de cada integrante na condução do grupo; - valorização de cada depoimento; - promoção do apoio mútuo." 3647 3979 W1986181224.pdf 5 31 separator 0.75520265 ¶ 3979 3981 W1986181224.pdf 5 32 text 0.9994558 "Esse desenvolvimento foi permeado pela criação de dinâmicas de grupo que motivaram as pessoas a manifestarem seus sentimentos, crenças, opiniões e promoveram a discussão de temas sobre o viver com doença respiratória, relacionando com qualidadede vida." 3981 4240 W1986181224.pdf 5 33 separator 0.92274636 ¶ 4240 4242 W1986181224.pdf 5 34 text 0.99952 "Analisando esses princípios, percebemos que foram essenciais, para que pudéssemos avaliar positivamente o grupo deconvivências como definitório para que cumprisse sua proposta de educação participativa, solidária e que promovesse o crescimento de todos, tanto do ponto de vista da própria convivência com a doença,quanto da expansão de suas possibilidades enquanto seres humanos." 4242 4628 W1986181224.pdf 5 35 separator 0.9297935 ¶ 4628 4630 W1986181224.pdf 5 36 text 0.9982557 "Procuramos destacar elementos que foram apresentados com relevância pelas pessoas, no sentido de reconhecerem acontribuição do grupo na promoção de uma vida com mais qualidade, conforme os itens apresentados anteriormente." 4630 4857 W1986181224.pdf 5 37 separator 0.6403096 ¶ 4857 4859 W1986181224.pdf 5 38 text 0.9982775 "Identificamos que o grupo de convivência promoveu a aprendizagem de novas habilidades, como pode ser observado nas seguintes falas:" 4859 4996 W1986181224.pdf 5 39 separator 0.8400607 ¶ 4996 4998 W1986181224.pdf 5 40 text 0.9813702 "As reuniões do grupo são importantes. Nós aprendemos a caminhar, a encontrar outros caminhos. Eu aprendi muito (Sérgio)." 4998 5121 W1986181224.pdf 5 41 separator 0.6365668 ¶ 5121 5123 W1986181224.pdf 5 42 text 0.9614682 "Aprendi bastante no grupo. Eu me sinto bem aqui, gosto de vir (Iara" 5123 5193 W1986181224.pdf 5 43 paratext 0.8579544 ").Rev Latino-am Enfermagem 2005 janeiro-fevereiro; 13(1):7-14 www.eerp.usp.br/rlaeQualidade de vida na perspectiva..." 5193 5312 W1986181224.pdf 5 44 separator 0.9526448 ¶ 5312 5314 W1986181224.pdf 5 45 bibliography 0.98025566 Silva DMGV, Souza SS, Francioni FF, Meirelles BHS. 5314 5365 W1986181224.pdf 5 0 paratext 0.90665954 08/06/2022 12:29 O 0 18 W4281746708.pdf 9 1 title 0.67475724 PROCESSO ADMINISTRA TIVO DISCIPLINAR PERANTE A LEI 18 69 W4281746708.pdf 9 2 paratext 0.8724971 8.1 12/90 – ISSN 1678-0817 69 96 W4281746708.pdf 9 3 separator 0.9887061 ¶ 96 98 W4281746708.pdf 9 4 paratext 0.7942954 https://revistaft.com.br/o-processo-administrativo-disciplinar-perante-a-lei-8-1 12-90/ 10/2387 98 194 W4281746708.pdf 9 5 text 0.97447824 "3). Assim, ressalta-se que a Constituição Federal garante a amplitude mínima de defesa, isto é, um patamar em que o cidadão possa exercer seu direito à alegação, se assim desejar." 194 377 W4281746708.pdf 9 6 separator 0.9860201 ¶ 377 379 W4281746708.pdf 9 7 text 0.60995275 Veri 379 384 W4281746708.pdf 9 0 paratext 0.99030924 Sustainability 2022 ,14, 16580 6 of 20 0 38 W4312125679.pdf 5 1 separator 0.9945271 ¶ 38 40 W4312125679.pdf 5 2 title 0.84853923 Power generation only; 42 65 W4312125679.pdf 5 3 separator 0.8422128 ¶ 65 67 W4312125679.pdf 5 4 title 0.5686388 Heat generation only; 69 91 W4312125679.pdf 5 5 separator 0.51558584 ¶ 91 93 W4312125679.pdf 5 6 text 0.6670079 Combined heat and power generation. 95 131 W4312125679.pdf 5 7 separator 0.85558057 ¶ 131 133 W4312125679.pdf 5 8 text 0.99807745 "Due to the reduced thermal capacity of the geothermal region with which the modeling of the power plants was implemented, electricity generation became the primary goal. However, it was decided to introduce a specific power plant with an installation for a district heating system (DHS) in order to evaluate the exploitation of the resource in a combined power plant." 133 508 W4312125679.pdf 5 9 separator 0.9824145 ¶ 508 510 W4312125679.pdf 5 10 text 0.9748615 Four groups of cycles can be distinguished: 510 554 W4312125679.pdf 5 11 separator 0.99163175 ¶ 554 556 W4312125679.pdf 5 12 title 0.8816143 Case Abbreviation Comment 556 582 W4312125679.pdf 5 13 separator 0.94686437 ¶ 582 584 W4312125679.pdf 5 14 table 0.796202 1. Direct supercritical CO 2cycle D_sCO 2 Figure 3a 584 636 W4312125679.pdf 5 15 separator 0.65793574 ¶ 636 638 W4312125679.pdf 5 16 table 0.8245101 "2.Indirect sCO 2cycle with ORC (binary cycle)I_sCO 2_ORC Figure 3b" 638 707 W4312125679.pdf 5 17 separator 0.8817564 ¶ 707 709 W4312125679.pdf 5 18 table 0.7900346 "3.Direct supercritical CO 2cycle with cogeneration;D_sCO 2_DHS ADHS located between turbine stages, Figure 4a" 709 825 W4312125679.pdf 5 19 separator 0.4685044 ¶ 825 827 W4312125679.pdf 5 20 table 0.79378587 "D_sCO 2_DHS BDHS located after the production well, Figure 4b" 827 893 W4312125679.pdf 5 21 separator 0.93477774 ¶ 893 895 W4312125679.pdf 5 22 table 0.72583807 "4.Direct sCO 2cycle combined with ORCD_sCO 2_ORC ARecovery heat exchanger located before the injection well, Figure 5a" 895 1022 W4312125679.pdf 5 23 separator 0.5039059 ¶ 1022 1024 W4312125679.pdf 5 24 table 0.65011007 "D_sCO 2_ORC BRecovery heat exchanger" 1024 1063 W4312125679.pdf 5 25 caption 0.4866241 1063 1064 W4312125679.pdf 5 26 table 0.60521567 "located after" 1064 1079 W4312125679.pdf 5 27 caption 0.49552816 the 1079 1083 W4312125679.pdf 5 28 table 0.5830081 production ¶ 1083 1096 W4312125679.pdf 5 29 caption 0.5045004 well, Figure 1096 1109 W4312125679.pdf 5 30 table 0.6489383 5b 1109 1112 W4312125679.pdf 5 31 separator 0.9952583 ¶ 1112 1114 W4312125679.pdf 5 32 text 0.99945486 "The Direct sCO 2cycle, presented in Figure 3a, represents the simplest cycle for the exploitation of the geothermal resource. This power plant foresees a direct expansion in the dedicated turbine of the sCO 2coming from the geothermal well. After that, the sCO 2is cooled before the injection well, and the heat released to the cooling fluid is not recovered." 1114 1479 W4312125679.pdf 5 33 separator 0.71009815 ¶ 1479 1481 W4312125679.pdf 5 34 text 0.99943125 "Due to partial CO 2sequestration (sequestration rate around 5%), an additional CO 2stream supplies the cycle. In the second case (Figure 3b), which shows an indirect sCO 2cycle with the ORC, the electric power is generated only by the expansion in the turbine in the ORC." 1481 1757 W4312125679.pdf 5 35 separator 0.94371855 ¶ 1757 1759 W4312125679.pdf 5 36 text 0.9992897 "The sCO 2in the geothermal well works in a closed loop and is used as a hot source to feed the Organic Rankine Cycle via a dedicated heat exchanger. Heat extracted by sCO 2in the reservoir is transferred to the ORC working fluid, which circulates in the cycle containing basic elements: turbine with generator, condenser, and pump." 1759 2096 W4312125679.pdf 5 37 separator 0.95159626 ¶ 2096 2098 W4312125679.pdf 5 38 text 0.9989008 "The next two implemented models represent two solutions where the goal is to maximize the recovery of energy that is lost from the sCO 2cycle by cogeneration application." 2098 2271 W4312125679.pdf 5 39 separator 0.9011886 ¶ 2271 2273 W4312125679.pdf 5 40 text 0.99953175 "These two configurations are based on the already presented, basic direct sCO 2cycle, which was extended by adding an extra heat exchanger for heat transfer to circulating water in the DHS. Both variants are presented in Figure 4 and the distinction between them relies on the location of the applied heat exchanger." 2273 2595 W4312125679.pdf 5 41 separator 0.97660375 ¶ 2595 2597 W4312125679.pdf 5 42 text 0.9976918 "A direct supercritical CO 2cycle with cogeneration combines electricity production with heat generation for the district heating system. In this work, two different arrange- ments were analyzed: DHS between turbine stages with lower source temperature (Figure 4a); DHS after outlet production well with higher source temperature (Figure 4b)." 2597 2951 W4312125679.pdf 5 0 paratext 0.91424626 Bibliography 199 0 16 W4289524256.pdf 214 1 separator 0.9783471 ¶ 16 18 W4289524256.pdf 214 2 bibliography 0.99643695 formation on carbonaceous grains,” Astronomy and Astrophysics 344, 681–686 (1999). 18 101 W4289524256.pdf 214 3 separator 0.96771383 ¶ 101 103 W4289524256.pdf 214 4 bibliography 0.99787855 "[263]G. Vidali, J. Roser, G. Manicó, V. Pirronello, H. B. Perets, and O. Biham, “Formation of molecular hydrogen on analogues of interstellar dust grains: experiments and modelling,” Journal of Physics: Conference Series 6, 36–58 (2005)." 103 345 W4289524256.pdf 214 5 separator 0.9564622 ¶ 345 347 W4289524256.pdf 214 6 bibliography 0.9979017 "[264]Schlapbach, L. and Züttel, A., “Hydrogen-storage materials for mobile applications,” Nature 414, 353–358 (2001)." 347 467 W4289524256.pdf 214 7 separator 0.9481045 ¶ 467 469 W4289524256.pdf 214 8 bibliography 0.99796027 "[265]V. Tozzini and V. Pellegrini, “Prospects for hydrogen storage in graphene,” Phys. Chem. Chem. Phys. 15, 80–89 (2013)." 469 594 W4289524256.pdf 214 9 separator 0.94944084 ¶ 594 596 W4289524256.pdf 214 10 bibliography 0.99791694 "[266]R. Nagar, B. P. Vinayan, S. S. Samantaray, and S. Ramaprabhu, “Recent advances in hydrogen storage using catalytically and chemically modified graphene nanocomposites,” J. Mater. Chem. A 5, 22897–22912 (2017)." 596 814 W4289524256.pdf 214 11 separator 0.95348 ¶ 814 816 W4289524256.pdf 214 12 bibliography 0.99796784 "[267]J. Abe, A. Popoola, E. Ajenifuja, and O. Popoola, “Hydrogen energy, economy and storage: Review and recommendation,” International Journal of Hydrogen Energy 44, 15072–15086 (2019)." 816 1007 W4289524256.pdf 214 13 separator 0.95319 ¶ 1007 1009 W4289524256.pdf 214 14 bibliography 0.9980563 "[268]V. Meregalli and M. Parrinello, “Review of theoretical calculations of hydrogen storage in carbon-based materials,” Appl. Phys. A 72, 143–146 (2001)." 1009 1166 W4289524256.pdf 214 15 separator 0.95961654 ¶ 1166 1168 W4289524256.pdf 214 16 bibliography 0.9980616 "[269]S. Zhou, G. Gweon, and A. e. a. Fedorov, “Substrate-induced bandgap opening in epitaxial graphene,” Nat. Mater. 6, 770–775 (2007)." 1168 1306 W4289524256.pdf 214 17 separator 0.96326303 ¶ 1306 1308 W4289524256.pdf 214 18 bibliography 0.9979025 "[270]D. Haberer, D. V. Vyalikh, S. Taioli, B. Dora, M. Farjam, J. Fink, D. Marchenko, T. Pichler, K. Ziegler, S. Simonucci, M. S. Dresselhaus, M. Knupfer, B. Büchner, and A. Grüneis, “Tunable band gap in hydrogenated quasi-free-standing graphene,” Nano Letters 10, 3360–3366 (2010), pMID: 20695447, https://doi.org/10.1021/nl101066m ." 1308 1649 W4289524256.pdf 214 19 separator 0.9528686 ¶ 1649 1651 W4289524256.pdf 214 20 bibliography 0.9978589 "[271]D. Haberer, L. Petaccia, Y. Wang, H. Quian, M. Farjam, S. Jafari, H. Sachdev, A. Federov, D. Usachov, D. Vyalikh, X. Liu, O. Vilkov, V. Adamchuk, S. Irle, M. Knupfer, B. Büchner, and A. Grüneis, “Electronic properties of hydrogenated quasi-free-standing graphene,” physica status solidi (b) 248, 2639–2643 (2011)." 1651 1976 W4289524256.pdf 214 21 separator 0.96988326 ¶ 1976 1978 W4289524256.pdf 214 22 bibliography 0.9977439 "[272]D. C. Elias, R. R. Nair, T. M. G. Mohiuddin, S. V. Morozov, P. Blake, M. P. Halsall, A. C. Ferrari, D. W. Boukhvalov, M. I. Katsnelson, A. K. Geim, and K. S. Novoselov, “Control of graphene’s properties by reversible hydrogenation: Evidence for graphane,” Science 323, 610–613 (2009), https://www.science.org/doi/pdf/10.1126/science.1167130 ." 1978 2332 W4289524256.pdf 214 23 separator 0.9480091 ¶ 2332 2334 W4289524256.pdf 214 24 bibliography 0.99787074 "[273]R. Grassi, T. Low, and M. Lundstrom, “Scaling of the energy gap in pattern- hydrogenated graphene,” Nano Letters 11, 4574–4578 (2011), pMID: 21999430, https://doi.org/10.1021/nl2017338 ." 2334 2530 W4289524256.pdf 214 25 separator 0.95741695 ¶ 2530 2532 W4289524256.pdf 214 26 bibliography 0.9979382 "[274]K. Tada, J. Haruyama, H. X. Yang, M. Chshiev, T. Matsui, and H. Fukuyama, “Graphene magnet realized by hydrogenated graphene nanopore arrays,” Applied Physics Letters 99, 183111 (2011), https://doi.org/10.1063/1.3653286 ." 2532 2763 W4289524256.pdf 214 27 separator 0.9429824 ¶ 2763 2765 W4289524256.pdf 214 28 bibliography 0.99793905 "[275]C. Lin, Y. Feng, Y. Xiao, M. Dürr, X. Huang, X. Xu, R. Zhao, E. Wang, X.-Z. Li, and Z. Hu, “Direct observation of ordered configurations of hydrogen adatoms on graphene,” Nano Letters 15, 903–908 (2015), pMID: 25621539, https://doi.org/10.1021/nl503635x ." 2765 3029 W4289524256.pdf 214 29 separator 0.9546927 ¶ 3029 3031 W4289524256.pdf 214 30 bibliography 0.9978913 "[276]S. Naghdi, G. Sanchez-Arriaga, and K. Y. Rhee, “Tuning the work function of graphene toward application as anode and cathode,” Journal of Alloys and Compounds 805, 1117–1134 (2019)." 3031 3222 W4289524256.pdf 214 31 separator 0.9720166 ¶ 3222 3224 W4289524256.pdf 214 32 bibliography 0.99731797 "[277]S. E. Huber, T. Hell, M. Probst, and A. Ostermann, “Numerical investigation of the elastic scattering of hydrogen (isotopes) and helium at graphite (0001) surfaces at beam energies of 1 to 4 ev using a split-step fourier method,” Theor. Chem. Acc. 132, 1337 (2013)." 3224 3501 W4289524256.pdf 214 33 separator 0.9749133 ¶ 3501 3503 W4289524256.pdf 214 34 bibliography 0.99765 "[278]T. Aizawa, R. Souda, S. Otani, Y. Ishizawa, and C. Oshima, “Bond softening in monolayer graphite formed on transition-metal carbide surfaces,” Phys. Rev. B 42, 11469–11478 (1990)." 3503 3692 W4289524256.pdf 214 35 separator 0.96901035 ¶ 3692 3694 W4289524256.pdf 214 36 bibliography 0.9975229 [279]T. A. et al., “Phonon-dispersion of monolayer graphite on pt(111) and nbc surfaces – 3694 3784 W4289524256.pdf 214 0 paratext 0.9612931 Neurotoxins and Melatonin Current Neuropharmacology , 2010 , Vol. 8 , No. 3 209 0 82 W2020386021.pdf 15 1 separator 0.98229575 ¶ 83 85 W2020386021.pdf 15 2 bibliography 0.9975012 "[229] Solmaz, I., Gurkanlar, D., Goksoy, C., Ozkan, M., Erdogan, E. (2009) Antiepileptic activity of melatonin in guinea pigs with pen- tylenetetrazol-induced seizures. Neurol. Res ., 31, 989-995." 85 287 W2020386021.pdf 15 3 separator 0.9509994 ¶ 288 290 W2020386021.pdf 15 4 bibliography 0.9894809 "[230] Sotthibundhu, A., Phansuwan-Pu jito, P., Govitrapong, P. (2 010) Melatonin increases proliferation of cultured neural stem cells ob- tained from adult mouse subventricular zone. J. Pineal Res ., in press." 290 509 W2020386021.pdf 15 5 separator 0.95737326 ¶ 510 512 W2020386021.pdf 15 6 bibliography 0.9979886 "[231] Sperk, G. (1994) Kainic acid seizures in the rat. Prog. Neurobiol ., 42, 1-32." 512 600 W2020386021.pdf 15 7 separator 0.9042727 ¶ 601 603 W2020386021.pdf 15 8 bibliography 0.9981326 "[232] Stascia, P., Ulanski, P., Rosiak, J.M. (1998) Melatonin as a hy- droxyl radical scavenger. J. Pineal Res ., 25, 65-66." 603 730 W2020386021.pdf 15 9 separator 0.9168268 ¶ 731 733 W2020386021.pdf 15 10 bibliography 0.9981146 "[233] Steranka, L.R., Sanders-Bush, E. 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(2003) Melatonin increases glutathione peroxidase" 9092 9227 W2020386021.pdf 15 0 paratext 0.9768686 "Avi Brisman: On Narrative and Green Cultural Criminology IJCJ&SD 67 Online version via www.crimejusticejournal.com © 2017 6(2)" 0 144 W2619619030.pdf 3 1 title 0.500876 responsibility and 144 164 W2619619030.pdf 3 2 text 0.57203954 province of individuals 164 188 W2619619030.pdf 3 3 title 0.38598222 (if 189 193 W2619619030.pdf 3 4 text 0.4037851 there 193 199 W2619619030.pdf 3 5 title 0.39691275 is 199 202 W2619619030.pdf 3 6 text 0.5347382 202 203 W2619619030.pdf 3 7 title 0.38153386 a 203 204 W2619619030.pdf 3 8 text 0.48664826 duty 204 209 W2619619030.pdf 3 9 title 0.40264735 or re sponsibility 209 228 W2619619030.pdf 3 10 text 0.5061728 "at all) to protect and preserve nature—the natural" 228 286 W2619619030.pdf 3 11 title 0.35838544 environment 287 299 W2619619030.pdf 3 12 text 0.40243253 "—our planet and its ecosystems (" 299 337 W2619619030.pdf 3 13 paratext 0.36108816 Brisman 337 344 W2619619030.pdf 3 14 title 0.33136892 and 344 348 W2619619030.pdf 3 15 paratext 0.4047819 South 348 354 W2619619030.pdf 3 16 text 0.98355085 "2017b). Many of such stories plac e the onus on youth and absolve adults of responsibility for the future of the bios phere: they ask the next generation to instruct the present generation about how to cons ider and act in the interest of future generations. Such processes of ‘adultificati on’ (Hayward 2012, 2013) discharge adults of their intergenerational responsibilit y, while working in tandem with processes of ‘infantilisation’—another Hayward (201 2, 2013) concept— and self‐absorption to augment the risks and threats that jeopa rdise the existence and quality of life for future generations." 354 978 W2619619030.pdf 3 17 separator 0.99635154 ¶ 979 981 W2619619030.pdf 3 18 title 0.99166536 3. Highlighting commonalities and differences in post‐apocalyptic or dystopian novels 981 1068 W2619619030.pdf 3 19 separator 0.9733843 ¶ 1069 1071 W2619619030.pdf 3 20 text 0.99084085 "in their depictions of the relat ionship between environment and conflict for the purpose of emphasizing ‘what is at stake and warn us of what is to come if we do not change our ecocidal tendencies’ and underscoring the need for ‘ “alternative stories” (Richardson 1995: 213)—ones that present an imagined future of a healthier Earth and a better world for humanity on this planet’ (Brisman 2015: 303). ¶" 1071 1493 W2619619030.pdf 3 21 separator 0.6076097 ¶ 1495 1497 W2619619030.pdf 3 22 text 0.999265 "But these endeavors have been undertaken in the absence of dial ogue with—indeed, without acknowledgment of—narrative criminology. This paper seeks to re ctify this. I turn now to my two key arguments based on Presser and Sandberg’s points (above) ab out the relationship of stories to harmful action." 1497 1808 W2619619030.pdf 3 23 separator 0.99663055 ¶ 1810 1812 W2619619030.pdf 3 24 title 0.991014 Revealing harmful action, shaping future action 1813 1862 W2619619030.pdf 3 25 separator 0.9912134 ¶ 1863 1865 W2619619030.pdf 3 26 text 0.99953955 "As stated in the Introduction, stories can expose how we have c aused environmental degradation, despoliation and destruction—what we might call ‘environmental crime in literature’. Stories can also serve to influence and inspire better relationships with n ature by demonstrating how and why we might engage in more environmentally‐friendly behaviors and the dangers of desisting from those patterns and practices that threaten the long‐term p rospects of humans, nonhumans, animals and the biosphere. While the hope is that investigation s of stories might be conducted for these reasons, irrespective of their relationship to existing o r emerging criminological paradigms, such endeavors extend the range of both narrative criminology a nd green cultural criminology." 1865 2661 W2619619030.pdf 3 27 separator 0.7292831 ¶ 2662 2664 W2619619030.pdf 3 28 text 0.99946314 "At the same time, such inquiries might help avoid Aspden and Ha yward’s (2015: 245) concern that narrative criminology ‘deteriorate into a poststructural l anguage game concerned only with stories about reality and not reality itself’." 2664 2906 W2619619030.pdf 3 29 separator 0.8685543 ¶ ¶ 2907 2913 W2619619030.pdf 3 30 text 0.5642459 "1) Narratives or stories can reveal how we have instigated or sustained harmful action with respect to the environment," 2913 3041 W2619619030.pdf 3 31 bibliography 0.36947286 as well 3042 3050 W2619619030.pdf 3 32 text 0.419061 as portray a 3050 3063 W2619619030.pdf 3 33 bibliography 0.3848516 world 3063 3069 W2619619030.pdf 3 34 text 0.3848769 suffering 3069 3079 W2619619030.pdf 3 35 bibliography 0.37562537 from 3080 3085 W2619619030.pdf 3 36 text 0.46579123 "the failure to effect desistance from harmful action." 3085 3143 W2619619030.pdf 3 37 separator 0.9226819 ¶ ¶ 3144 3150 W2619619030.pdf 3 38 text 0.9927401 "According to Sandberg (2010: 448), ‘[w]hether true or false, th e multitude of stories people tell r e f l e c t , a n d h e l p u s u n d e r s t a n d , t h e c o m p l e x n a t u r e o f v a l u e s , identities, cultures, and communities’ (see also 2010: 455). Allhoff and Buciak (2013: 23 2) assert that ‘[f]ictional work can be seen as a mirror of society, its fears and hopes’, what I might call ‘narrative as reflection’." 3150 3604 W2619619030.pdf 3 39 separator 0.96195805 ¶ 3605 3607 W2619619030.pdf 3 40 text 0.99952865 "But sometimes the mirror gets cruddy. What we need is some non‐ toxic, ecologically‐friendly surface cleaner. As Delgado (19 89: 2440) observes, ‘[s]tories h umanize us. They emphasize our differences in ways that can ultimately bring us closer togethe r. They allow us to see how the world looks from behind someone else’s spectacles. They challen ge us to wipe off our own lenses and ask, “Could I have been overlooking something all along?”’ Unlike other types of crime and harm, when it comes to the environment, we do not often know th at (a) harm has occurred—it is not visible—and, if (a) harm has occurred, whether it is part o f the cost of doing business and/or rises to the level of ‘crime’ (see, for example, Brisman 2008, 2014b; South and Brisman 2013;" 3607 4396 W2619619030.pdf 3 0 bibliography 0.73107994 Ji et al. 0 9 W2945541133.pdf 9 1 title 0.86131257 ssVEP-fMRI Integration 9 32 W2945541133.pdf 9 2 separator 0.9933735 ¶ 32 34 W2945541133.pdf 9 3 text 0.998064 "The work is important to neurorobotics for several reasons: (1) This approach could be used to examine a wide range of hypotheses regarding the neurophysiology of visual cortex an d its function for biological and artificial systems, (2) it pro vides a means to conduct the multi-modal information fusion and correlationanalysistorecovertheunderlyingneurophysio logical mechanisms, and (3) the core idea of the approach are inspiring for other brain data processing and the knowledge can be transferredtootherapplicationsaswell." 34 578 W2945541133.pdf 9 4 separator 0.9958973 ¶ 578 580 W2945541133.pdf 9 5 title 0.9791695 ETHICS STATEMENT 580 597 W2945541133.pdf 9 6 separator 0.9819178 ¶ 597 599 W2945541133.pdf 9 7 text 0.99044114 "All procedures were approved by the institutional review board of the University of Florida and were consistent with the Declaration of Helsinki on studies with humanparticipants." 599 785 W2945541133.pdf 9 8 title 0.9353932 AUTHOR CONTRIBUTIONS 785 805 W2945541133.pdf 9 9 separator 0.9726945 ¶ 805 807 W2945541133.pdf 9 10 text 0.9654144 "All authors had full access to all the data in the study and tak e responsibility for the integrity of the data and the accuracy o f thedataanalysis." 807 961 W2945541133.pdf 9 11 bibliography 0.9281786 "AKandHJ:conceptualization.HJ,ZY,andAK: methodology.HJandNP:investigation.NP:formalanalysis .HJ, AK,andBC:writing.BCandAK:supervision.BC,NZ,andAK: fundingacquisition." 961 1132 W2945541133.pdf 9 12 separator 0.9918597 ¶ 1132 1134 W2945541133.pdf 9 13 title 0.93986064 FUNDING 1134 1142 W2945541133.pdf 9 14 separator 0.98008525 ¶ 1142 1144 W2945541133.pdf 9 15 text 0.9811894 "This work was supported by 973 Program 2015CB351703 and NationalNaturalScienceFoundationGrant91648208toBCan d by National Institute of Mental Health grants R01 MH112558 and R01 MH097320 to AK. 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Q., Nordby, H.,etal.(2005).Assessingthespatiotemporalevolutionofneurona lactivation withsingle-trialevent-relatedpotentialsandfunctional MRI. Proc. Natl.Acad. Sci.U.S.A. 102,17798–17803.doi:10.1073/pnas.0505508102" 5603 5890 W2945541133.pdf 9 58 separator 0.9641991 ¶ 5890 5892 W2945541133.pdf 9 59 bibliography 0.99806696 "Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G . R., Amunts, K., et al. (2005). A new spm toolbox for combining probabilist ic cytoarchitectonic maps and functional imaging data. Neuroimage 25, 1325– 1335.doi:10.1016/j.neuroimage.2004.12.034" 5892 6160 W2945541133.pdf 9 60 separator 0.9667221 ¶ 6160 6162 W2945541133.pdf 9 61 bibliography 0.9979469 "Falotico,E.,Vannucci,L.,Ambrosano,A.,Albanese,U.,Ulbrich,S. ,VasquezTieck, J. C., et al. (2017). Connecting artificial brains to robots in a co mprehensive simulation framework: the neurorobotics platform. Front. 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Singapore:WorldScientific." 6888 6993 W2945541133.pdf 9 68 separator 0.9181832 ¶ 6993 6995 W2945541133.pdf 9 69 bibliography 0.99780077 "Hyvarinen, A. (1999). Fast and robust fixed-point algorithms for independent component analysis. IEEE Trans. Neural Netw. 10, 626–634. doi:10.1109/72.761722" 6995 7155 W2945541133.pdf 9 70 separator 0.92998517 ¶ 7155 7157 W2945541133.pdf 9 71 paratext 0.9828934 Frontiers in Neurorobotics | www.frontiersin.org 10 May 2019 | Volume 13 | Article 24 7157 7243 W2945541133.pdf 9 0 text 0.9824213 "laboratory testing such as angiotensin-converting enzyme (ACE) may provide additional support, but lack the sensi- tivity and specificity for definitive diagnosis [ 1,4]." 0 174 W3192297034.pdf 1 1 separator 0.99589735 ¶ 174 176 W3192297034.pdf 1 2 title 0.982283 Case presentation 176 194 W3192297034.pdf 1 3 separator 0.994524 ¶ 194 196 W3192297034.pdf 1 4 text 0.9996362 "A ten-year-old African-American female presented to the pediatric ophthalmology clinic in referral from her primary care provider for evaluation of bilateral eyelid swelling, tearing and itching for approximately one month. Her past medical history included premature birth, jejunal atresia with resection and jejuno-ileal pri- mary anastomosis, short gut syndrome, asthma, and mild eczema. The patient ’s birth history was complicated by Human Immunodeficiency Virus (HIV) positive test- ing of her mother, but with normal prenatal ultrasounds and negative congenital HIV testing, and was otherwise uncomplicated. Her family history included allergic rhin- itis and asthma in her mother, and there was no known family history of sarcoidosis or granulomatous disease." 196 990 W3192297034.pdf 1 5 separator 0.9428755 ¶ 990 992 W3192297034.pdf 1 6 text 0.9997233 "The patient ’s asthma was first suspected when she pre- sented at seven months old with wheezing and cough that responded well to albuterol concerning for reactive airway disease. She is now followed by a pediatric pul- monologist for moderate persistent asthma with pul- monary function tests that revealed a moderate obstruction pattern with normal lung volumes and dif- fusing capacity of lung for carbon monoxide. She is treated with an inhaled corticosteroid for asthma control and albuterol as needed for symptom exacerbation." 992 1543 W3192297034.pdf 1 7 separator 0.96256983 ¶ 1543 1545 W3192297034.pdf 1 8 text 0.9997341 "Her presenting ophthalmologic exam was notable for bilateral papillary conjunctivitis and mild superficial ker- atopathy, as well as mild boggy lid edema. She was started on ketotifen fumarate and artificial tears for pre- sumed allergic conjunctivitis. Five months later at her follow-up exam, she had persistent symptoms and exam with giant papillary reaction of the palpebral conjunctiva of both upper eyelids. Upon referral to an allergist, she was found to have normal serum IgE level, and skin test- ing did not identify a likely allergen exposure. She had been diagnosed with eczema clinically in the past by her primary care provider and was confirmed by allergist. In- flammatory markers were elevated including sedimenta- tion rate 38 mm/hr. (reference range 0 –20 mm/hr) and C-reactive protein 4.18 mg/dL (reference range 0 –1 mg/ dL); however, serum ACE and lysozyme were normal, and chest radiograph did not reveal hilar lymphadenop- athy. At this point, the worsening palpebral reaction and overall picture including history of atopic disease were felt to best support a diagnosis of vernal keratoconjunc- tivitis. She was started on a topical regimen including corticosteroid, olopatadine and tacrolimus ointment with mild improvement in lid swelling." 1545 2856 W3192297034.pdf 1 9 separator 0.9668704 ¶ 2856 2858 W3192297034.pdf 1 10 text 0.99973065 "She was next seen approximately 6 weeks later when she presented to the pediatric emergency departmentwith significant worsening of bilateral upper eyelid swell- ing (Fig. 1). Her exam continued to demonstrate giant papillary reaction temporally in the bilateral superior palpebral conjunctiva. Of note, the upper lid swelling was much more pronounced than at previous visits and the lacrimal glands were palpable bilaterally. She had continued to use topical steroid, tacrolimus, and artificial tears, but had discontinued olopatadine as she had min- imal to no itching. Decision was made to pursue tissue diagnosis by obtaining a lacrimal gland biopsy. She was also referred to pediatric rheumatology for evaluation as she complained of joint pains at her emergency depart- ment visit. The onset of the joint pain was around the same time as the patient ’s swollen eyelids, however there was no joint effusion, limitation, or tenderness on exam." 2858 3836 W3192297034.pdf 1 11 separator 0.9583583 ¶ 3836 3838 W3192297034.pdf 1 12 text 0.99962693 "Subsequent radiographs of bilateral ankles and elbows also showed no joint effusion or signs of chronic arth- ritis. Exam did show bilateral flexible pes planus which likely contributed to patient ’s lower extremity pain with high impact weight-bearing activity. She had dry skin on exam without ichthyosiform cutaneous manifestations that can be seen in children with sarcoidosis [ 2]. There were no discrete lesions or papules, and thus skin biopsy was not pursued. There was also no unexplained fever, weakness, alopecia, sicca symptoms, or oral ulcers by history or exam. Extensive lab evaluation showed nor- mal/negative complete blood count, liver, kidney, and thyroid function, creatine kinase, complement studies (C3, C4, CH50), anti-nuclear antibody, anti-neutrophil cytoplasmic antibody, and urinalysis. Sedimentation rate was persistently elevated at 25 mm/hr. Genetic testing for the NOD2 gene mutation associated with Blau syn- drome was not performed due to lack of uveitis, rash, and arthritis seen in this disease." 3838 4905 W3192297034.pdf 1 13 separator 0.93080676 ¶ 4905 4907 W3192297034.pdf 1 14 text 0.99950325 "Eight months after initial presentation, biopsy of the right lacrimal gland was performed in an anterior trans- septal fashion through the temporal upper lid crease." 4907 5077 W3192297034.pdf 1 15 separator 0.9067495 ¶ 5077 5079 W3192297034.pdf 1 16 text 0.99363524 "Histopathologic evaluation of the lacrimal gland speci- men demonstrated chronic-appearing inflammatory changes with poorly-formed noncaseating granulomas and widespread destruction of normal acini and gland structures. Staining for CD68 marker for epithelioid cells" 5079 5354 W3192297034.pdf 1 17 separator 0.97558177 ¶ 5354 5356 W3192297034.pdf 1 18 caption 0.992187 "Fig. 1 Photograph of our patient showing bilateral temporal upper eyelid swellingPowell" 5356 5446 W3192297034.pdf 1 19 paratext 0.8943472 et al. Pediatric Rheumatology (2021) 19:117 Page 2 of 6 5446 5511 W3192297034.pdf 1 0 paratext 0.98534536 fpls-09-00181 February 15, 2018 Time: 16:26 # 5 0 47 W2793689900.pdf 4 1 separator 0.9487059 ¶ 47 49 W2793689900.pdf 4 2 title 0.97636175 Chen et al. AtEMB1990 in Chloroplast and Embryo 49 97 W2793689900.pdf 4 3 separator 0.94016993 ¶ 97 99 W2793689900.pdf 4 4 text 0.9909447 "inemb1990-1/C mutant harbors the Basta (Bas) resistance gene, which facilitated segregation analysis of the mutant alleles." 99 225 W2793689900.pdf 4 5 separator 0.7910675 ¶ 225 227 W2793689900.pdf 4 6 text 0.9993984 "Progenies of self-pollinated emb1990-1/C mutant segregate in a 2:1 ratio of Bas-resistant to Bas-sensitive (Table 2), the expected theoretical ratio for heterozygous to wild-type plants when the homozygous emb1990-1 embryos were lethal (Meinke et al., 2008). We then performed reciprocal crosses with emb1990-1/C to wild-type plants, and analyzed the segregation of Bas resistance in the progenies. The result showed that transmission efficiencies of both female and male gametophytes in emb1990/C mutants were normal (Table 2), indicating that knock out of EMB1990 did not affect the capacity of gametophytes." 227 853 W2793689900.pdf 4 7 separator 0.9565782 ¶ 853 855 W2793689900.pdf 4 8 text 0.99964863 "To confirm the seed abortion in emb1990 mutants was caused by the disruption of EMB1990, genetic complementation was applied to test whether the white ovules could be rescued. A genomic fragment of EMB1990/YLMG1-1, including the 943 bp gene sequence and 609 bp upstream of the ATG codon, was introduced into both mutants. Then PCR screening and phenotypic analysis in the T2 progeny of the complementation lines showed that no aborted seeds were observed in homozygous emb1990 mutants (Figures 1E,F and Supplementary Figures S1E,F). These results confirmed that EMB1990/YLMG1-1 was responsible for the seed abortion in corresponding mutants, indicating the EMB1990/YLMG1-1 gene is essential for seed formation in Arabidopsis." 855 1603 W2793689900.pdf 4 9 separator 0.9956911 ¶ 1603 1605 W2793689900.pdf 4 10 title 0.9752933 "Morphological Development of Homozygous emb1990 Embryo Is Disrupted after the Globular Stage" 1605 1702 W2793689900.pdf 4 11 separator 0.9859141 ¶ 1702 1704 W2793689900.pdf 4 12 text 0.99372435 "To investigate the mechanisms of seed abortion in the emb1990 heterozygous mutants, we examined ovule development inemb1990-1/C and emb1990-2/C mutants compared with wild-type plant, through a whole mount clearing technique. We found no obvious differences between wild-type and emb1990/C embryos from the zygote up to the early globular stage (Supplementary Figure S2). Embryogenesis in wild- type continued to follow the programmed stages successively: globular, transition, heart, torpedo and curled cotyledon." 1704 2233 W2793689900.pdf 4 13 separator 0.5647112 ¶ 2233 2235 W2793689900.pdf 4 14 text 0.99964786 "Meanwhile in the white ovule of emb1990, embryo development was trapped at the globular stage (Figure 2), and the abnormal shape of the arrested emb1990 embryo became more severe following the course of development." 2235 2457 W2793689900.pdf 4 15 separator 0.60481966 ¶ 2457 2459 W2793689900.pdf 4 16 text 0.9996685 "When wild-type embryos reached the bent-cotyledon stage, the emb1990 embryos were still unable to develop beyond the globular stage, and instead displayed abnormal cell division and shape alterations with no formation of shoot apical meristem or cotyledonous primordium (Figures 2F,L,R).These results indicate that morphological development of a homozygous emb1990 embryo is disrupted after the globular stage, thus Arabidopsis embryogenesis requires the function of the EMB1990/YLMG1-1 gene." 2459 2966 W2793689900.pdf 4 17 separator 0.99614966 ¶ 2966 2968 W2793689900.pdf 4 18 title 0.9738576 "TheEMB1990/YLMG1-1 Is Expressed Widely in a Variety of Tissues and Organs" 2968 3044 W2793689900.pdf 4 19 separator 0.9881084 ¶ 3044 3046 W2793689900.pdf 4 20 text 0.9996417 "To investigate the expression pattern of the EMB1990/YLMG1-1 gene, quantitative PCR was performed to evaluate its relative transcription levels in various Arabidopsis tissues, with GAPDH applied as the reference gene. The results showed that EMB1990/YLMG1-1 was expressed at different levels in nearly all examined tissues, including the vegetative and reproductive organs. The relative expression levels were most abundant in inflorescences and siliques, whereas the lowest transcript expression was detected in mature root, stem and leaf tissue (Figure 3A)." 3046 3622 W2793689900.pdf 4 21 separator 0.9069601 ¶ 3622 3624 W2793689900.pdf 4 22 text 0.999628 "To further analyze the spatial expression pattern, the EMB1990/YLMG1-1 promoter was fused with a b-glucuronidase (GUS) reporter to monitor its expression in Arabidopsis transgenic plants (pYLMG1-1::GUS). In the open flower, strong GUS signals were detected in sepals, filaments and stigmas, while the young flower bud in the inflorescence showed little signal compared to the flower after fertilization (Figures 3B,C)." 3624 4050 W2793689900.pdf 4 23 separator 0.90823543 ¶ 4050 4052 W2793689900.pdf 4 24 text 0.99970263 "In 7DAG and 14DAG seedlings, the GUS staining was clearly observed in the shoot meristem, hypocotyl, root and vascular bundles of cotyledons, as well as in the veins of mature leaves (Figures 3D–F). In addition, we generated pYLMG1- 1::YLMG1-1-Venus transgenic plants to evaluate the expression during embryo development. Fluorescence observation showed that no Venus signal could be detected at the early globular stage. After that stage, the Venus fluorescence was primarily observed in the cotyledon primordia of embryos in the heart stage, especially distributed on the paraxial side of embryo cotyledon primordia at the torpedo and bent cotyledon stage (Figures 3G–J). This expression pattern of EMB1990/YLMG1-1 during embryo development was associated with the defective embryo phenotype after the globular stage in emb1990 mutants." 4052 4916 W2793689900.pdf 4 25 separator 0.996701 ¶ 4916 4918 W2793689900.pdf 4 26 title 0.97094226 "EMB1990/AtYLMG1-1 Is Localized in the Chloroplast" 4918 4970 W2793689900.pdf 4 27 separator 0.98834765 ¶ 4970 4972 W2793689900.pdf 4 28 text 0.9976889 "The SUBA database (The Subcellular Localization of Proteins in Arabidopsis Database2) was used for the prediction of EMB1990/YLMG1-1 exclusive targeting to the plastid (Hooper et al., 2017). Work by Kabeya et al., 2010 also revealed that 2http://suba.live/" 4972 5237 W2793689900.pdf 4 29 separator 0.9957179 ¶ 5237 5239 W2793689900.pdf 4 30 table 0.92795116 "TABLE 2 | Genetic transmission analysis of emb1990-1 inArabidopsis. Female Male BASTARBASTASBASTAR/BASTASTE (Female) TE (Male) emb1990-1/C emb1990-1/C 1007 486 2.07:1 NA NA emb1990-1/CC/C 772 734 1.05:1 104.6% NA C/C emb1990-1/C 693 708 0.98:1 NA 97.9% BASTAR, BASTA-resistant; BASTAS, BASTA-sensitive; TE, transmission efficiency D(BASTAR/BASTAS)100%; NA, not applicable." 5239 5626 W2793689900.pdf 4 31 separator 0.97708726 ¶ 5626 5628 W2793689900.pdf 4 32 paratext 0.98258185 Frontiers in Plant Science | www.frontiersin.org 5 February 2018 | Volume 9 | Article 181 5628 5718 W2793689900.pdf 4 0 paratext 0.8334478 Accepted Manuscript 0 19 W1105054751.pdf 1 1 separator 0.98270106 ¶ 19 21 W1105054751.pdf 1 2 paratext 0.4981693 Title 21 27 W1105054751.pdf 1 3 title 0.86086565 ": Gastroretentive montmorillonite-tetracycline nanoclay for the treatment of Helicobacter pylori infection" 27 135 W1105054751.pdf 1 4 separator 0.9864648 ¶ 135 137 W1105054751.pdf 1 5 contact 0.95040965 "Author: Valentina Iannuccelli Eleonora Maretti Monia Montorsi Cecilia Rustichelli Francesca Sacchetti Eliana Leo" 137 252 W1105054751.pdf 1 6 separator 0.9651049 ¶ 252 254 W1105054751.pdf 1 7 paratext 0.9543835 "PII: S0378-5173(15)30019-3 DOI: http://dx.doi.org/doi:10.1016/j.ijpharm.2015.06.049Reference: IJP 15024" 254 360 W1105054751.pdf 1 8 separator 0.73681337 ¶ 360 362 W1105054751.pdf 1 9 paratext 0.83339316 To appear in: International Journal of Pharmaceutics 362 415 W1105054751.pdf 1 10 separator 0.9098263 ¶ 415 417 W1105054751.pdf 1 11 paratext 0.8190086 "Received date: 17-3-2015 Accepted date: 25-6-2015" 417 469 W1105054751.pdf 1 12 separator 0.99107385 ¶ 469 471 W1105054751.pdf 1 13 paratext 0.74650526 Please cite this article as: I 471 502 W1105054751.pdf 1 14 bibliography 0.38674966 annuccelli 502 512 W1105054751.pdf 1 15 paratext 0.5000036 , Valentina, Maretti, Eleonora, Montorsi, Monia, 512 560 W1105054751.pdf 1 16 separator 0.62901306 ¶ 560 562 W1105054751.pdf 1 17 bibliography 0.9828648 Rustichelli, Cecilia, Sacchetti, Francesca, Leo, Eliana, Gastroretentive montmorillonite-tetracycline nanoclay for the treatment of Helicobacter pylori infection.InternationalJournal of Pharmaceutics http://dx.doi.org/10.1016/j.ijpharm.2015.06.049 562 810 W1105054751.pdf 1 18 separator 0.99262714 ¶ 810 812 W1105054751.pdf 1 19 text 0.7594601 This is a PDF file of an unedited manuscript that has been accepted for publication. 812 896 W1105054751.pdf 1 20 separator 0.8716718 ¶ 896 898 W1105054751.pdf 1 21 text 0.9710745 "As a service to our customers we are providing this early version of the manuscript.The manuscript will undergo copyediting, typesetting, and review of the resulting proofbefore it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers thatapply to the journal pertain." 898 1276 W1105054751.pdf 1 0 paratext 0.9799481 "Zhang et al. BMC Chemistry (2020) 14:20 https://doi.org/10.1186/s13065-020-00670-w" 0 97 W3014060577.pdf 0 1 separator 0.96202993 ¶ 97 99 W3014060577.pdf 0 2 title 0.9678838 RESEARCH ARTICLE 99 116 W3014060577.pdf 0 3 separator 0.68210256 ¶ 116 118 W3014060577.pdf 0 4 title 0.9847285 "Effects of temperature and shear on the structural, thermal and pasting properties of different potato flour" 118 233 W3014060577.pdf 0 5 separator 0.9892442 ¶ 233 235 W3014060577.pdf 0 6 contact 0.9772837 Ke Zhang, Yang Tian, Chenglong Liu and Wentong Xue* 235 287 W3014060577.pdf 0 7 separator 0.9913666 ¶ 287 289 W3014060577.pdf 0 8 title 0.9120122 Abstract 289 298 W3014060577.pdf 0 9 separator 0.9950396 ¶ 299 301 W3014060577.pdf 0 10 text 0.9996244 "Background: The properties of potato flour will be different due to different processing parameters, which will affect their processing adaptability. In this paper, different potato flour were investigated to determine viscoelastic properties and structural transformation using thermodynamics, rheological and spectrum methods. Potato flour was prepared by drying at different temperature after soaking in citric acid, microwave and steamed respectively. The treated samples were dried by hot air and then compared with the freeze-dried potato flour. Four kinds of potato flour showed different properties after shearing at high temperature." 301 950 W3014060577.pdf 0 11 separator 0.90908456 ¶ 950 952 W3014060577.pdf 0 12 text 0.9996877 "Results: Differential scanning calorimetry (DSC) results revealed that potato flour with low gelatinization had lower enthalpy and faster melting process than freeze-dried potato powder. RVA and texture results showed that potato flour with low gelatinization had the best retrogradation property and the stable gel. X-ray diffraction (XRD) patterns revealed that the crystalline properties of different potato flour after shearing at high temperature were the same. In addition, low gelatinization potato flour presented a crystalline structure or strong internal order. Fourier-transform infrared spectroscopy (FTIR) spectra showed that high temperature and shearing mainly caused δ-deformation of O–H in intact potato granules." 952 1689 W3014060577.pdf 0 13 separator 0.90859663 ¶ 1689 1691 W3014060577.pdf 0 14 text 0.99940264 "Conclusion: Freeze drying and hot air drying at low temperature made potato flour had better gel stability than microwave and steamed treatment. Hot air drying at low temperature made potato flour had good retrogradation after hot shearing, which was more conducive to the formation of hot-processed products." 1691 2007 W3014060577.pdf 0 15 separator 0.9922584 ¶ 2007 2009 W3014060577.pdf 0 16 paratext 0.5648611 Keywords: Pot 2009 2023 W3014060577.pdf 0 17 title 0.352163 ato flour 2023 2032 W3014060577.pdf 0 18 paratext 0.44058958 , Thermodynamics, Pasting properties, Structure, Texture 2032 2088 W3014060577.pdf 0 19 separator 0.8974189 ¶ 2088 2090 W3014060577.pdf 0 20 paratext 0.92998976 "© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://crea- tivecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdo - main/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data." 2090 3180 W3014060577.pdf 0 21 title 0.98420185 Introduction 3180 3192 W3014060577.pdf 0 22 separator 0.9956942 ¶ 3192 3194 W3014060577.pdf 0 23 text 0.99963 "Potato (Solanum tuberosum L.) is an annual herb of Sola - naceae, its fresh tubers can be eaten after simple pro - cessing. As one of the world’s major food crops, potato contains ascorbic acid, phenolic substances and other important active ingredients [1, 2]. However, high water content and metabolic activity lead to short shelf life and high storage cost, and limit the promotion of potatoes. Processing fresh potatoes into dried whole flour or starch can effectively solve this problem. Potato flour is one of dehydrated potato products. Granular, chip or powder products are prepared with fresh potatoes. The tradi - tional processing technology includes cleaning, peeling, selection, slicing, dehydration and drying [3, 4]. The qual - ity of potato flour is affected by processing method and parameters. Several methods have been used in potato flour by various authors to characterize the relationship between processing technology and product properties." 3194 4177 W3014060577.pdf 0 24 separator 0.89540017 ¶ 4177 4179 W3014060577.pdf 0 25 text 0.9930802 "Browning of fresh potato during processing is an important factor affecting the quality of dry potato flour, which can be divided into enzymatic browning and non-enzymatic browning. Enzymatic browning makes Open AccessBMC Chemistry" 4179 4414 W3014060577.pdf 0 26 separator 0.9577292 ¶ 4414 4416 W3014060577.pdf 0 27 contact 0.99451804 *Correspondence: xwt@cau.edu.cn 4416 4449 W3014060577.pdf 0 28 separator 0.9049816 ¶ 4449 4451 W3014060577.pdf 0 29 contact 0.9904967 College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China 4451 4548 W3014060577.pdf 0 0 title 0.9612454 Influence of using abrasive particles on Surface hardness of free cutting brass in ball burnishing process 0 106 W4242028774.pdf 3 1 separator 0.7265812 ¶ ¶ 108 114 W4242028774.pdf 3 2 paratext 0.90298134 "¶ ¶ 11 Journal of Production and Industrial Eng ineering www.rame.org.in" 116 344 W4242028774.pdf 3 3 text 0.9960907 "hardness achiev ed is 88 BHN which is higher than turned sample hardness. Maximum hardness is achieved at 25 kgf force where the deformation of peaks and valleys seam s to prominent." 345 538 W4242028774.pdf 3 4 separator 0.9969253 ¶ 540 542 W4242028774.pdf 3 5 title 0.98372334 TABLE IV. 542 552 W4242028774.pdf 3 6 separator 0.8396816 ¶ 555 557 W4242028774.pdf 3 7 title 0.62304145 HARDNESS OF BRASS BURNISHED USING 557 591 W4242028774.pdf 3 8 table 0.49144953 F 591 593 W4242028774.pdf 3 9 title 0.51665044 INE ABRASIVE 593 605 W4242028774.pdf 3 10 table 0.77990395 PARTICLES 605 615 W4242028774.pdf 3 11 separator 0.6837545 ¶ 617 619 W4242028774.pdf 3 12 table 0.9829574 "Burnishing force, kgf 1st 2nd Average 5 78.00 74.00 76.00 10 81.00 80.00 80.50 15 80.00 79.00 79.50 20 87.00 85.00 86.00 25 88.00 88.00 88.00 ¶ 7075808590 5 10 15 20 25Brinell hardness, BHN Burnishing force, kgf ¶" 619 881 W4242028774.pdf 3 13 separator 0.93425775 ¶ 883 885 W4242028774.pdf 3 14 caption 0.99005854 Figure 5. Burnishing force Vs. BHN (Brass) 885 928 W4242028774.pdf 3 15 separator 0.99305654 ¶ ¶ 930 936 W4242028774.pdf 3 16 title 0.99062806 "C. Effect of using medium size abrasive particles on hardness of brass" 936 1011 W4242028774.pdf 3 17 separator 0.9878659 ¶ 1013 1015 W4242028774.pdf 3 18 text 0.99930155 "The experiments are carried out with the addition of medium size abrasive particles in this condition on brass workpiece. The various of le vel of burnishing force used during the ball burnishing process and hardness values are given in Table 5 and other parameters such a s burnishing speed, feed and number of passes are kept at constant level." 1015 1378 W4242028774.pdf 3 19 separator 0.7286489 ¶ 1380 1382 W4242028774.pdf 3 20 text 0.9990867 "As observed from the Fig 6 and table V the hardne ss value is found to be fluctuating as burnishing force increases. According to this value for medium abrasive workpiece burnished surface is 7.53% hardened then the turned surface." 1382 1628 W4242028774.pdf 3 21 separator 0.99682784 ¶ 1630 1632 W4242028774.pdf 3 22 title 0.9775797 TABLE V. 1633 1642 W4242028774.pdf 3 23 separator 0.7313591 ¶ 1645 1647 W4242028774.pdf 3 24 title 0.56205696 HARDNESS OF 1647 1660 W4242028774.pdf 3 25 table 0.48565707 BRAS 1660 1664 W4242028774.pdf 3 26 title 0.4975513 S BURNISH 1664 1673 W4242028774.pdf 3 27 table 0.92050076 "ED USING MEDIUM ABRASIVE PARTICLES Burnishing force, kgf 1st 2nd Average 5 76.00 80.00 78.00 10 81.00 83.00 82.00 15 82.00 80.00 81.00 20 88.00 84.00 86.00 25 88.00 85.00 87.00 ¶ Fi ¶" 1673 1906 W4242028774.pdf 3 28 caption 0.6865042 gure 6. Burnishing force Vs. BHN (Brass) 1906 1947 W4242028774.pdf 3 29 separator 0.99607325 ¶ 1949 1951 W4242028774.pdf 3 30 title 0.9913109 V. CONCLUSIONS 1951 1966 W4242028774.pdf 3 31 separator 0.99473745 ¶ 1968 1970 W4242028774.pdf 3 32 text 0.98824584 "The following are the conclusio ns of this project work; 1. Hardness of a turned brass specimen was 75 BHN and improved to 89 BHN during dry ball improving hardness by 18.67% with respect to turned sample. 2. In fine abrasive particle used ball burnishing, the hardness improved by 17.3 3% with respect to turned sample 3. Using medium abrasive particle the hardness can be improved to 87 BHN which is 16% greater turned sample. 4. Use of abrasive particles neither improved hardness beyond the level of dry burnishing condition and nor decrea sed the hardness than turned sample. Hence, more studies are requiring to establish the role of abrasives in burnishing process 5. The higher level of f orce i.e. 25 kgf have proved to improve the hardness higher than any other level of forces" 1970 2809 W4242028774.pdf 3 0 text 0.9996516 "Parents of children with overweight and obesity reported more concern with regard to their child’s weight. Although our study did not indicate that overweight and obese children experience more health conditions (e.g. asthma symptoms, allergies), several health conditions are reported to be potentially associated with overweight and obesity (e.g. type 2 diabetes, sleep problems) [32]. Hypothetically, parents and children may have visited the GP for conditions unmeasured in the current study. Also, the smaller number of children with specific conditions may have created a lack of power to detect an effect of weight status in the current study. Nevertheless, other researchers have reported that parents are more aware and likely to identify the overweight of their 6-year-old child, compared to parents with younger children, and therefore concern with regard to the child’s weight may have increased among these parents [33]." 0 961 W2962732319.pdf 5 1 separator 0.9963173 ¶ 961 963 W2962732319.pdf 5 2 title 0.984693 "Associations between Underweight and Health Outcomes" 963 1018 W2962732319.pdf 5 3 separator 0.993141 ¶ 1018 1020 W2962732319.pdf 5 4 text 0.99970055 "Underweight children had slightly higher odds for being treated adversely compared to normal weight children. Two studies reported that adverse treatment was associated with both underweight and overweight [13] [15]. Although their results indicate that the odds for experiencing adverse treatment are much greater for overweight/obese children compared to the odds for underweight children, future studies will need to include underweight as a separate subgroup to further explore theassociations with health outcomes." 1020 1554 W2962732319.pdf 5 5 separator 0.96913105 ¶ 1554 1556 W2962732319.pdf 5 6 text 0.99970406 "Parents of underweight children reported slightly higher odds for higher levels of concern compared to parents of normal weight children. Also, a higher frequency of GP visits and lower scoring on the general health scale of the Child Health Questionnaire at age 7 years was observed. Hypothetically, underweight children may be more prone to seasonal diseases (such as influenza or a cold) which may partly explain the increased risk for visits to the GP and the overall lower scores on general health." 1556 2074 W2962732319.pdf 5 7 separator 0.9711845 ¶ 2074 2076 W2962732319.pdf 5 8 text 0.99970925 "Although we observed some interesting associations between underweight in children and parent-reported health outcomes, these associations are to be interpreted with caution. We, for example, did not measure whether these children had specific diseases during preschool. Because children with relative under- weight may develop a normal weight when they grow older [34], longitudinal data needs to provide more insight in weight patterns of these children. Health care practitioners may be attentive to health problems associated with childhood underweight so that appropriate advice can be given; however, more research is needed before reliable advice with regard to counseling for underweight children and their parents can be given." 2076 2835 W2962732319.pdf 5 9 separator 0.99540937 ¶ 2835 2837 W2962732319.pdf 5 10 title 0.9930105 "Associations between Weight Status Trajectories and Health Outcomes" 2837 2907 W2962732319.pdf 5 11 separator 0.99445456 ¶ 2907 2909 W2962732319.pdf 5 12 text 0.9997407 "Our study indicates that children with an increasing BMI between the age of 5 and 7 years have higher odds for being treated adversely and feeling insecure, as also reported by other studies [18,19,20]. Weight patterns have been associated with lower school functioning among elementary school-aged children [35]. The association between weight patterns and lower school functioning has been found to be mediated by internalizing factors (e.g. loneliness, low self-esteem) [35,36]. This emphasizes the need to develop and evaluate appropriate interventions for overweight/ obese children at young ages to prevent further decreases in school performance, social participation, health outcomes and quality of life. Also, the pathways and environmental characteristics through which health outcomes are affected by overweight or obesity needfurther clarification; qualitative studies are required to gain moreinsight into these mechanisms. Combining multiple resources, such as child, parent report and teacher reports, or performingobservational studies, may help to elucidate the associationbetween weight and health outcomes." 2909 4061 W2962732319.pdf 5 13 separator 0.98187757 ¶ 4061 4063 W2962732319.pdf 5 14 text 0.9997783 "Based on the methods used in other studies we categorized children in weight status trajectories using the international cutoffvalues at age 5 and age 7 years, which may result in a relativelycrude categorization [35,36]. Children may decrease or increasewithin a weight category, but not reach the criterion to becategorized in another weight category. We explored whether gainin BMI was associated with higher risk for adverse psychosocialoutcomes (data not shown). Children that gained BMI had ahigher risk for being treated adversely and feeling insecure at age7, as reported by their parents. Also, parents reported moreconcern with regard to their child’s weight. Considering thephysical outcomes, children had a higher parent-reported OR forhaving one or more health conditions or visits to the GP when theygained BMI between age 5 and 7. This is in line with the results weobserved using the trajectories approach for high stable andincreasing weight status. Longitudinal studies having access tomultiple BMI measures may be able to create individual pathwaysof BMI development using statistical models [37,38,39]. Theselongitudinal trajectories or developmental pathways may revealmore distinct patterns of for example, late or early onset BMI gain,and can be related to health outcomes [37,38,39]." 4063 5373 W2962732319.pdf 5 15 separator 0.99652445 ¶ 5373 5375 W2962732319.pdf 5 16 title 0.99274784 Methodological Considerations 5375 5405 W2962732319.pdf 5 17 separator 0.9957494 ¶ 5405 5407 W2962732319.pdf 5 18 text 0.9996702 "Strengths of this study include the large sample size, the ability to create subgroups based on the international cut-off values forBMI, inclusion of a large group of underweight children and theavailability of data at child age 5 years and child age 7 years." 5407 5669 W2962732319.pdf 5 19 separator 0.80598557 ¶ 5669 5671 W2962732319.pdf 5 20 text 0.99975884 "Limitations include the missing data at child age 7 years and parents self-report of the children’s health outcomes. Also, mothersof children with complete outcome measures differ from motherswith missing outcome data; however, this does not necessarilyinfluence the associations under study. With regard to the itemsused to measure psychosocial health outcomes of the child, thesehave not been examined with regard to validity and reliability.Additional analyses (data not shown) were performed to gaininsight in the validity of the items used. These analyses showedthat normal weight mothers reported a higher OR for theiroverweight or obese child to be treated adversely and feel insecure,normal weight mothers also reported more concern for theiroverweight or obese child compared to normal weight children(data not shown). Nevertheless, we recommend future research toevaluate the validity and reliability of the items measuringpsychosocial health outcomes." 5671 6636 W2962732319.pdf 5 21 separator 0.9894254 ¶ 6636 6638 W2962732319.pdf 5 22 text 0.9997521 "The use of parent self-report may have led to over- or underestimation of the children’s health outcomes and needs tobe taken into account when interpreting the findings. Measures ofdepression and self-esteem of the child were not included in thequestionnaire because of the already reasonably high respondentburden. Although child report may have provided more accurateestimates of consequences on health outcomes, measuringconcepts such as self-esteem and depression is known to bechallenging among young children [40]. Also, at younger age self-concept indicators, such as teasing and insecurity, may be moreinformative compared to self-esteem questionnaires due to thedevelopmental stage of the children [40]." 6638 7354 W2962732319.pdf 5 23 separator 0.99699444 ¶ 7354 7356 W2962732319.pdf 5 24 title 0.9901666 Conclusions 7356 7368 W2962732319.pdf 5 25 separator 0.99517155 ¶ 7368 7370 W2962732319.pdf 5 26 text 0.98918 "In conclusion, parents reported their overweight, obese and underweight children to be more often treated adversely or feelinsecure due to their weight. Parents of overweight, obese andPediatric Overweight and Health Outcomes" 7370 7598 W2962732319.pdf 5 27 separator 0.97247404 ¶ 7598 7600 W2962732319.pdf 5 28 paratext 0.98525065 PLOS ONE | www.plosone.org 6 June 2013 | Volume 8 | Issue 6 | e67383 7600 7669 W2962732319.pdf 5 0 paratext 0.98304063 70 R. B. A. Campos and C. Azzoni 0 32 W3179962386.pdf 14 1 separator 0.97338814 ¶ 32 34 W3179962386.pdf 14 2 title 0.7457876 References 34 45 W3179962386.pdf 14 3 separator 0.99402916 ¶ 45 47 W3179962386.pdf 14 4 bibliography 0.99810016 "Ahlfeldt, G. M., Redding, S. J., Sturm, D. M., and Wolf, N. (2016). The Economics of Density: Evidence from the Berlin Wall. Econometrica 83(6) , 2127–2189." 47 206 W3179962386.pdf 14 5 separator 0.96979356 ¶ 206 208 W3179962386.pdf 14 6 bibliography 0.9977946 Alonso, W. (1964). Location and Land Use . Cambridge: Harvard University Press. 208 288 W3179962386.pdf 14 7 separator 0.9177416 ¶ 288 290 W3179962386.pdf 14 8 bibliography 0.9977674 "Anas, A., and Kim, I. (1996). General Equilibrium Models of Polycentric Urban Land Use with Endogenous Congestion and Job Agglomeration. Journal of Urban Economics 28(1) , 318– 325." 290 476 W3179962386.pdf 14 9 separator 0.9784633 ¶ 476 478 W3179962386.pdf 14 10 bibliography 0.9980582 "Anas, A., Arnott, R., and Small, K. A. (1998). Urban Spatial Structure. Journal of Economic Literature 36(3) , 1426–1464." 478 602 W3179962386.pdf 14 11 separator 0.9736623 ¶ 602 604 W3179962386.pdf 14 12 bibliography 0.99785465 "Beckmann,M.J.(1974).SpatialEquilibriumintheHousingMarket. Journal of Urban Economics 1(1), 99–107." 604 705 W3179962386.pdf 14 13 separator 0.9644115 ¶ 705 707 W3179962386.pdf 14 14 bibliography 0.99804157 "Bender, B., and Hwang, H. (1985). Hedonic Housing Price Indices and Secondary Employment Centers. Journal of Urban Economics l(17) , 90-107." 707 850 W3179962386.pdf 14 15 separator 0.97215486 ¶ 850 852 W3179962386.pdf 14 16 bibliography 0.99787146 "Bowman, A. W., and Azzalini, A. (1997). Applied Smoothing Techniques for Data Analysis: The Kernel Approach with S-Plus Illustrations . Oxford: Oxford Science Publications." 852 1027 W3179962386.pdf 14 17 separator 0.9800413 ¶ 1027 1029 W3179962386.pdf 14 18 bibliography 0.996732 "Campos, R. B. A. (2018). Subcentralidades e prêmio salarial intra-urbano na região metropoli- tana de São Paulo. São Paulo: Programa de Pós-Graduação em Economia; Faculdade de Economia, Administração e Contabilidade; Universidade de São Paulo. (Tese de Doutorado)." 1029 1300 W3179962386.pdf 14 19 separator 0.98475134 ¶ 1300 1302 W3179962386.pdf 14 20 bibliography 0.9978756 "Campos, R. B. A., and Azzoni, R. C. (2020). Dispersão concentrada do emprego: uma incursão sobre os modelos teóricos e abordagens empíricas. Revista Brasileira de Estudos Regionais e Urbanos 13(4) , 606–627." 1302 1514 W3179962386.pdf 14 21 separator 0.9870136 ¶ 1514 1516 W3179962386.pdf 14 22 bibliography 0.9980126 "Castells, M., Hall, P., and Hall, P. G. (1994). Technopoles of the World: the Making of Twenty- First-Century Industrial Complexes. London, New York: Routledge." 1516 1679 W3179962386.pdf 14 23 separator 0.9506832 ¶ 1679 1681 W3179962386.pdf 14 24 bibliography 0.9979661 "Craig, S. G., and Ng, P. T. (2001). Using Quantile Smoothing Splines to Identify Employment Subcenters in a Multicentric Urban Area. Journal of Urban Economics 49(1) , 100–120." 1681 1860 W3179962386.pdf 14 25 separator 0.9735068 ¶ 1860 1862 W3179962386.pdf 14 26 bibliography 0.98564124 "Duranton, G., andPuga, D.(2015).UrbanLandUse.InG.Duranton, J.V.HendersonandW.C. Strange (Eds.), Handbook of Regional and Urban Economics (pp. 467–560). Amsterdam: Elsevier." 1862 2039 W3179962386.pdf 14 27 separator 0.97853756 ¶ 2039 2041 W3179962386.pdf 14 28 bibliography 0.997961 "Ewing, R. H., Pendall, R., and Chen, D. D. T. (2002). Measuring Sprawl and its Impacts. Smart Growth America (technical report)." 2041 2172 W3179962386.pdf 14 29 separator 0.9589657 ¶ 2172 2174 W3179962386.pdf 14 30 bibliography 0.997981 "Fotheringham, A. A., Brunsdon, C., and Charlton, M. (2000). Quantitative Geography: Perspec- tives on Spatial Data Analysis . London: Sage." 2174 2316 W3179962386.pdf 14 31 separator 0.9413195 ¶ 2316 2318 W3179962386.pdf 14 32 bibliography 0.9979304 "Fotheringham, A. A., Brunsdon, C., and Charlton, M. (2002). Geographically Weighted Regres- sion: the analysis of spatially varying relationship . New York: Wiley." 2318 2484 W3179962386.pdf 14 33 separator 0.9695313 ¶ 2484 2486 W3179962386.pdf 14 34 bibliography 0.9979628 "Fujita, M. (1988). A Monopolistic Competition Model of Spatial Agglomeration: Differentiated Products Approach. Regional Science and Urban Economics 18(1) , 87–124." 2486 2652 W3179962386.pdf 14 35 separator 0.96915925 ¶ 2652 2654 W3179962386.pdf 14 36 bibliography 0.9976592 "Fujita, M., and Ogawa, H. (1982). Multiple Equilibria and Structural Transition of Non- Monocentric Urban Configurations. Regional Science and Urban Economics 12(2) , 161– 191." 2654 2834 W3179962386.pdf 14 37 separator 0.9920268 ¶ 2834 2836 W3179962386.pdf 14 0 text 0.9841745 "losis with high sensitivity, and batch-to-batch variability can be corrected through batch-specific analysis using tuberculosis-negative sputum controls." 0 154 W2972542232.pdf 10 1 separator 0.9959261 ¶ 154 156 W2972542232.pdf 10 2 title 0.9918077 DISCUSSION 156 167 W2972542232.pdf 10 3 separator 0.99623376 ¶ 167 169 W2972542232.pdf 10 4 text 0.9996008 "We report evaluation of BlaC as a biomarker that is conserved within the tubercu- losis complex for rapid diagnosis. The unique characteristics of the BlaC active site,constitutive expression, and conservation in the tuberculosis complex make it anexcellent biomarker ( 48–50). The REFtb assay requires no processing and can be accomplished in 10 min. We show that the CDG-3 probe represents a substantialimprovementoverotherprobesinthatitisstableandshowsnegligiblecross-reactivitywith other bacteria. Very small amounts of CDG-3 can be used in these assays, makingREFtb a very inexpensive test, expected to cost less than a dollar per sample. Afford-ability and simplicity make REFtb a promising option for POC use that would allowmore TB cases to be identified. Examination of 160 clinical specimens from suspectedtuberculosis-infected patients yielded a high sensitivity and specificity of 88.1% and86.1%, respectively, obtained from ROC analyses with high statistical significance(P/H110050.0002) and correct predictive value. These observations suggest REFtb is more sensitive than smear microscopy, which has a sensitivity of 20 to 80% ( 4). The negative predictivevalueofREFtbis93%( P/H110210.0001),suggestingthatfewcasesaremissedand emphasizing its potential for use as a rapid triage test. These values for specificity andsensitivity are directly in line with recommendations from the WHO for a biomarker-based triage test to identify suspected TB patients ( 71). We are particularly excited by the observation that REFtb can detect the majority of smear-negative cases that wouldbe missed in diagnosis prior to obtaining culture results, since about 17% of tubercu-losistransmissionisthoughttooccurfromthesepatients( 72)." 169 1917 W2972542232.pdf 10 5 title 0.98184633 ImplementationofREFtbTABLE 2 Sensitivity and specificity of the reporter enzyme fluorescence diagnostic assay 1917 2024 W2972542232.pdf 10 6 separator 0.9527606 ¶ 2024 2026 W2972542232.pdf 10 7 table 0.99362975 "Group (no. of samples)a% Female (no.)bS/H11545,C/H11545(no.)cS/H11546,C/H11545(no.)dSpecificity (no.)e Age range 15–25 (11) 18.1 (2) 0 (1) 0 (0) 100 (10)26–35 (33) 51.5 (17) 57.1 (7) 87.5 (8) 89 (18)36–45 (38) 31.6 (12) 100 (11) 80 (5) 68 (22) f 46–55 (26) 19.2 (5) 100 (6) 66.6 (3) 76 (17)g 56–65 (37) 40.5 (15) 100 (7) 100 (6) 75 (24)h /H1102265 (15) 60.0 (9) 100 (3) 100 (2) 100 (10) Sex Male (100) 0.0 (100) 92 (25) 93.3 (15) 82 (60)Female (60) 100 (60) 80 (10) 77.7 (9) 81 (41) Total no. (160) 37.5 (60) 89 (35) 87.5 (24) 82 (101)" 2026 2579 W2972542232.pdf 10 8 separator 0.9806222 ¶ 2579 2581 W2972542232.pdf 10 9 text 0.97835386 "aClinical samples were divided into groups by age and sex to evaluate whether any of these differences impact the performance of the tuberculosis reporter enzyme fluorescent (REFtb) diagnostic assay. The totalnumber of samples (n) in each group is shown in parentheses." 2581 2852 W2972542232.pdf 10 10 separator 0.4751796 2852 2853 W2972542232.pdf 10 11 text 0.96332306 "¶ bThe percentage of female patients within the group. The number of samples in this group that were from female patients is shown in parentheses." 2853 3001 W2972542232.pdf 10 12 separator 0.7017148 ¶ 3001 3003 W2972542232.pdf 10 13 text 0.93300396 "cSensitivity of the REFtb assay versus smear-positive (S /H11001) and culture-positive (C /H11001) samples calculated as the number of positives by REFtb divided by the number of positives by both smear and culture times 100 tomake a percentage. The number (no.) of samples in this group that were smear positive and culturepositive is shown in parentheses." 3003 3363 W2972542232.pdf 10 14 separator 0.67630464 ¶ 3363 3365 W2972542232.pdf 10 15 text 0.98408264 "dSensitivity of the REFtb assay versus smear-negative (S /H11002) and culture-positive samples calculated as the number of positives by REFtb divided by the number of positives by culture only times 100 to make apercentage. The number of samples in this group that were smear negative and culture positive is shownin parentheses." 3365 3697 W2972542232.pdf 10 16 separator 0.947705 ¶ 3697 3699 W2972542232.pdf 10 17 text 0.966245 "eSpecificity of the REFtb assay-negative samples versus samples negative by both smear and culture calculated as the number of negatives by REFtb divided by the number of negatives by both smear andculture times 100 to make a percentage. The number of samples in this group that were both smear andculture negative is shown in parentheses. Pvalues calculated using Boschloo’s exact test compared to the specificity of the /H1102265 age group." 3699 4144 W2972542232.pdf 10 18 separator 0.981893 ¶ 4144 4146 W2972542232.pdf 10 19 table 0.74235594 "fP/H110050.02. gP/H110050.06. hP/H110050.05." 4146 4195 W2972542232.pdf 10 20 paratext 0.4427965 Tuber 4195 4200 W2972542232.pdf 10 21 table 0.38542604 culosis 4200 4207 W2972542232.pdf 10 22 paratext 0.41592842 Diagnosis 4207 4217 W2972542232.pdf 10 23 table 0.4053171 with 4217 4222 W2972542232.pdf 10 24 paratext 0.67084223 Reporter Enzyme Fluorescence Journal of Clinical Microbiology 4222 4284 W2972542232.pdf 10 25 separator 0.83506954 ¶ 4284 4286 W2972542232.pdf 10 26 paratext 0.9863242 December 2019 Volume 57 Issue 12 e01462-19 jcm.asm.org 11 4286 4344 W2972542232.pdf 10 0 paratext 0.98680747 www.nature.com/scientificreports/3 0 34 W2912241675.pdf 2 1 separator 0.67529815 ¶ 34 36 W2912241675.pdf 2 2 paratext 0.9737648 SCiENtifiC REPORTS | (2019) 9:249 | DOI:10.1038/s41598-018-36971-3 36 116 W2912241675.pdf 2 3 title 0.51453394 In 116 118 W2912241675.pdf 2 4 text 0.998531 "oculated plants maintained greater soil moisture but were less drought tolerant than con- trols. After germination, the inoculated group maintained significantly greater soil moisture than controls from day 19 through day 102 (P < 0.05, Fig. 2, Table 1) during the entire well-watered growth period and during moderate drought. The inoculated plants, however, exhibited lower drought tolerance than controls as indicated by the significantly less negative (i.e. greater) turgor loss point (ΨTLP) of inoculated plants compared to controls (P = 0.017, Table 2). Prior to day 19, soil moisture did not significantly differ between the inoculated and control groups. Soil moisture of both the control and inoculated groups rapidly declined after drought began on day 99 until soil moisture of both groups declined to zero by day 118." 118 968 W2912241675.pdf 2 5 separator 0.9640058 ¶ 968 970 W2912241675.pdf 2 6 text 0.9969979 "After the experiment ended on day 132, soil chemistry (C, C:N, Cu, Fe, K, Mn, N, NO 3-N, organic matter, P , pH, Zn) and foliar N content did not significantly differ between groups (P > 0.05, Supplementary Table S2)." 970 1193 W2912241675.pdf 2 7 separator 0.9764085 ¶ 1193 1195 W2912241675.pdf 2 8 text 0.9990233 "Inoculated plants exhibited greater photosynthesis (A ) before soil moisture declined to zero but lower stomatal conductance (gs) after soil moisture declined to zero. A of the inoculated group was significantly greater than that of controls during moderate drought on days 104 and 112 (P = 0.014, 0.030), and mean A of the inoculated group during the entire moderate drought period before soil mois- ture declined to zero (days 99–117, yellow background, Fig. 3) was significantly greater than that of controls (P = 0.027). After day 118, mean gs of the inoculated group during the entire severe drought period after soil moisture declined to zero (days 118–131, pink background, Fig. 3) was significantly lower than that of controls" 1195 1951 W2912241675.pdf 2 9 table 0.9918865 "GerminationRoot:shoot biomassSoil moisture contentPhotosynthesis (A)Stomatal conductance (g s)Wilting scorePredawn leaf water potential Treatment 0.051 0.97 0.014 0.71 0.75 0.30 0.96 Day <0.0001 0.0009 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001 Treatment x Day0.020 0.72 <0.0001 0.01 0.03 0.75 0.15" 1951 2258 W2912241675.pdf 2 10 separator 0.9852618 ¶ 2258 2260 W2912241675.pdf 2 11 title 0.6549269 Table 1. Summary of P-values from linear mixed effects models describing the effects of treatment, day, and 2260 2368 W2912241675.pdf 2 12 table 0.5777206 "¶ the interaction (treatment x day) on germination, soil moisture, photosynthesis (A), stomatal conductance (gs), wilting score, and predawn leaf water potential. Significant values" 2369 2554 W2912241675.pdf 2 13 caption 0.4989527 at 2554 2557 W2912241675.pdf 2 14 table 0.48138368 P ≤ 0.05 2557 2566 W2912241675.pdf 2 15 caption 0.46030468 are bold 2566 2575 W2912241675.pdf 2 16 table 0.52231896 ed. 2575 2578 W2912241675.pdf 2 17 separator 0.96072596 ¶ 2578 2580 W2912241675.pdf 2 18 table 0.9934371 "Controls Inoculated Height (cm) 12.3 ± 0.40* 14.1 ± 0.25* ΨTLP (bars) −14.8 ± 0.61* −12.8 ± 0.32* Vcmax 37.9 ± 9.1 44.7 ± 6.2 Jmax 34.8 ± 2.8 34.1 ± 1.4 Rd −0.0034 ± 0.5 −0.73 ± 0.3" 2580 2772 W2912241675.pdf 2 19 separator 0.98942006 ¶ 2772 2774 W2912241675.pdf 2 20 title 0.7749737 Table 2. Physiological measurements of the control and inoculated groups during the well-waterd period 2774 2877 W2912241675.pdf 2 21 table 0.78768164 "¶ before drought was imposed. Asterisks indicate statistically significant differences between controls and inoculated groups at P ≤ 0.05. All values are expressed as means ± SE. Turgor loss point (ΨTLP), maximum rate of carboxylation (Vcmax), maximum rate of electron transport (Jmax), and dark respiration (Rd)." 2878 3198 W2912241675.pdf 2 22 separator 0.9898052 ¶ 3198 3200 W2912241675.pdf 2 23 caption 0.9896434 "Figure 2. Soil moisture of control and inoculated groups. Asterisks indicate significant differences between control and inoculated groups at P ≤ 0.05. All values are expressed as means ± SE. The well-watered period includes the green, grey, and blue background colors (days 1–98; (green = germination, blue = gas exchange measurements), yellow indicates the moderate drought period before soil moisture declined to zero (days 99–117), and pink indicates the severe drought period after soil moisture declined to zero (days 118–131)." 3200 3743 W2912241675.pdf 2 0 separator 0.9258032 ¶ 1 2 W4289533584.pdf 3 1 paratext 0.98063534 Revista Moinhos, vol.10, ano 5, 2021, Tangará da Serra – MT. 96 2 66 W4289533584.pdf 3 2 separator 0.99452543 ¶ 67 69 W4289533584.pdf 3 3 text 0.99974793 aprendizagem significativa. A sequência básica é capaz de formar o leitor crítico, pois esse procedimento metodológico é dividido em etapas que têm, como intuito, a construção do conhecimento prévio através da motivação e da introdução. A leitura é o momento de pensar, recapitular, relacionar conhecimentos de mundo ou enciclopédico e, na interpretação, ocorre a materialização da compreensão com a produção, que faz parte da etapa final. A trajetória das atividades de leitura e produção de poemas foi planejada em quatro etapas, denominadas no projeto como módulos, conforme explicitado anteriormente. O projeto ação foi desenvolvido na 2° fase do 3° ciclo (7°ano) B, no ano de 2016, da Escola Estadual André Antônio Maggi, no município de Ipiranga do norte-MT. A turma, no início do projeto, possuía 27 alunos, porém três alunos pediram transferência durante o período em que foram desenvolvidas as atividades, devido ao fluxo que ocorre durante a safra, ficando para a conclusão do projeto 24 alunos. 69 1075 W4289533584.pdf 3 4 title 0.98788106 Classificados Poéticos: arte versus realidade 1076 1122 W4289533584.pdf 3 5 text 0.9997696 Para a aplicação deste módulo, primeiramente os alunos receberam jornais para que recortassem classificados, foram apresentados, também, por meio do projetor multimídia, alguns classificados online. Em seguida, a professora pesquisadora questionou os alunos sobre a função e estrutura do gênero, o que contribuiu para que os alunos pudessem compreender o estilo da autora. A pesquisadora observou que, ao apresentar os classificados, havia uma boa parte dos alunos que não conheciam e nem sabiam a utilidade de um classificado. No momento da introdução os alunos foram encaminhados para o laboratório de informática, onde foi solicitado que visitassem o blog da poetiza e fizessem a leitura do e-book Livros e leituras, de Roseana Murray, livro este que apresenta sua autobiografia. Após a motivação e a introdução, iniciou-se a leitura do livro Classificados Poéticos, realizada em sala de aula. Como os alunos já possuíam conhecimento prévio referente aos gêneros classificados e à poesia, sobre o estilo e a vida da autora, a interpretação da obra ficou mais simples, e assim, até os alunos que diziam não se interessar pela leitura do texto literário se envolveram com a obra. A produção foi dividida em duas etapas. Na primeira etapa, foi solicitada aos 1123 2383 W4289533584.pdf 3 0 text 0.99869114 dat de accountant geen verantwoordelijkheid t.o.v. derden aanvaardt? Welke tekst zou hiervoor in het bevestigende geval in aanmerking komen? 0 140 W2971598062.pdf 2 1 separator 0.9952065 ¶ 140 142 W2971598062.pdf 2 2 title 0.59360194 4. Kan 142 149 W2971598062.pdf 2 3 text 0.7293413 de 149 152 W2971598062.pdf 2 4 title 0.58350873 openbare 152 161 W2971598062.pdf 2 5 text 0.7586813 accountant voor de 161 180 W2971598062.pdf 2 6 title 0.66357195 kleine onderneming 180 199 W2971598062.pdf 2 7 text 0.71251684 de 199 202 W2971598062.pdf 2 8 title 0.75214887 belastingaangifte 202 221 W2971598062.pdf 2 9 text 0.49500382 verzorg 221 228 W2971598062.pdf 2 10 title 0.71804535 en? 228 231 W2971598062.pdf 2 11 separator 0.995808 ¶ 231 233 W2971598062.pdf 2 12 text 0.99604857 Naast deze theoretische vragen werden de volgende praktische vragen vermeld: 233 310 W2971598062.pdf 2 13 separator 0.75612056 ¶ 310 312 W2971598062.pdf 2 14 text 0.9895353 1. Uitgaande van de gedachte dat de accountant optreedt bij de kleine onder­neming, mag hij dan, of behoort hij, onder eigen verantwoordelijkheid een belastingconsulent in (te) schakelen?Hoe staat hij tegenover informaties van cliënten m.b.t. hun belastingaangifte? 312 579 W2971598062.pdf 2 15 separator 0.512476 ¶ 579 580 W2971598062.pdf 2 16 text 0.98985237 "2. Kan de accountant nuttige adviezen geven in het kleine bedrijf, in aanmer­king nemend dat deze (daar) niet tot het terrein van de administratieve or­ganisatie en de bedrijfseconomie beperkt zullen zijn? 3. Ligt het op de weg van de accountant in de kleine onderneming het aanstellen van een commissaris te propageren?" 580 903 W2971598062.pdf 2 17 separator 0.9177052 ¶ 903 905 W2971598062.pdf 2 18 text 0.9990653 Als afzonderlijk discussiepunt werd tenslotte nog verwezen naar de achter de probleemstelling opgenomen opvattingen in de Engelse en Amerikaanse litera­tuur. 905 1063 W2971598062.pdf 2 19 separator 0.99356586 ¶ 1063 1065 W2971598062.pdf 2 20 text 0.99976456 De heer Baarsen gaf op vrijdagmorgen een uitgebreide toelichting op de pro­bleemstelling. Daarbij legde hij er de nadruk op - voor degene die de probleem­stelling, zoals hierboven opgesomd, leest, ook van belang - dat er bij punt 1 a priori van uitgegaan is, dat niet tot een goedkeurende verklaring bij de jaarreke­ning kan worden gekomen. Beziet punt 1 de controlekant, in punt 2 is het de advieskant die onder de loupe wordt genomen. In punt 3 is het de niet-goedkeu- rende verklaring waarop het accent werd gelegd; bij de discussies bleek vooral dit punt in het centrum van de belangstelling te staan.Dat de door de heer Baarsen samengestelde probleemstelling in een behoefte heeft voorzien, is gebleken o.m. uit het feit, dat de voor de groepsdiscussie ge­plande tijd (van 11.00-12.30 en van 14.30-17.00, dus 4 uur) voor wat de dis­cussiegroep waar ik me in bevond, en voor althans enkele andere groepen, te kort bleek! Blijkens de groepsverslagen is het zwaartepunt in de discussiegroepen vooral op de beantwoording van de eerste drie vragen gelegd; over de buiten­landse literatuur is nauwelijks van gedachte gewisseld, hetgeen naar mijn mening allerminst is te betreuren.Van de aan het eind van de middag door de rapporteurs samengestelde groeps­verslagen werd op zaterdagochtend een samenvatting gegeven door de Confe- rentieleider, drs. R. Besançon. De heer Besançon ving aan met te wijzen op de actualiteit van het vraagstuk in verband met de aanhangige wettelijke regeling van het accountantswezen. Voorts wees hij op de eenstemmigheid die er bij de groepsdiscussies bleek te hebben bestaan ten aanzien van de noodzaak om, welke weg men ook met de niet-goedkeurende verklaring zou gaan bewandelen, toch het tot dusver moeizaam bereikte niveau in de uitoefening van de accountants- arbeid te handhaven. Geen afbreuk mag worden gedaan aan het begrip dat in het maatschappelijk verkeer tot stand is gekomen over de verantwoordelijkheid, die de accountant met de goedkeurende verklaring dekt. 1065 3068 W2971598062.pdf 2 21 separator 0.98436546 ¶ 3068 3070 W2971598062.pdf 2 22 paratext 0.97883034 m a b blz. 385 3070 3085 W2971598062.pdf 2 23 separator 0.9962021 ¶ 3085 3087 W2971598062.pdf 2 0 paratext 0.95604765 2 0 1 W4323022800.pdf 1 1 separator 0.9947345 ¶ 2 4 W4323022800.pdf 1 2 title 0.91195804 Tables and Figures: 5 25 W4323022800.pdf 1 3 text 0.98696786 "Tables and Figures should not be inserted within the text. They sho uld be listed consecutively after the references in the order in which they were mentioned in the text. All tables should be numbered using Arabic numerals. Supply a caption (title) for each table, explaining the components of the table. Identify any previ ously published material by giving the original source in the form of a reference at the end of the table caption. Figures (graphs, line drawings, line art, maps, photomicrographs, etc) should be identified as “Figs” followed by the appropriate title (e.g. , Fig. 1. Title )." 25 645 W4323022800.pdf 1 4 separator 0.9957248 ¶ 646 648 W4323022800.pdf 1 5 text 0.6791234 Reference 648 658 W4323022800.pdf 1 6 title 0.61364913 s 658 659 W4323022800.pdf 1 7 text 0.9428996 ": In the text the Harvard referencing format (author, date) must be followed. All cited references in the text must appear on the list of references at the end of the paper. List references in alphabetical order, with journal n ame fully written and italicized." 659 927 W4323022800.pdf 1 8 separator 0.9961529 ¶ 929 931 W4323022800.pdf 1 9 title 0.95458 Examples 931 940 W4323022800.pdf 1 10 separator 0.9884186 ¶ 942 944 W4323022800.pdf 1 11 title 0.88936204 Journal citation 944 961 W4323022800.pdf 1 12 separator 0.97550106 ¶ 963 965 W4323022800.pdf 1 13 bibliography 0.99768984 "Ezemonye, L. & Tongo, I. (2010). Acute toxic effects of endosulfan and diazinon pesticides on adult amphibians ( Bufo regularis ). Journal of Environment and Ecotoxicology 2(5): 73 -78." 965 1155 W4323022800.pdf 1 14 separator 0.98733413 ¶ 1156 1158 W4323022800.pdf 1 15 bibliography 0.9979293 "Ophori , E.A., Atanunu, O., Johnny, J.F. & Adu, M.C. (2010). Seroprevalence of syphilis in apparently healthy students from a tertiary institution in Benin City, Nigeria. Japanese Journal of Infectious Diseases 63(6): 437 -439." 1158 1393 W4323022800.pdf 1 16 separator 0.9910972 ¶ 1394 1396 W4323022800.pdf 1 17 paratext 0.34057474 Books 1396 1402 W4323022800.pdf 1 18 separator 0.97257966 ¶ 1404 1406 W4323022800.pdf 1 19 bibliography 0.9973894 "Ogbeibu, A.E. (2005). Biostati stics, A Practical Approach to Research and Data Handling. Mindex Publishing Co. Ltd., Benin, City, Lagos, Abuja, Aba, 264 pp." 1406 1568 W4323022800.pdf 1 20 separator 0.9759589 ¶ ¶ 1570 1576 W4323022800.pdf 1 21 bibliography 0.9185813 Chapter in a Book 1576 1594 W4323022800.pdf 1 22 separator 0.86655265 ¶ 1596 1598 W4323022800.pdf 1 23 bibliography 0.99735993 "Schotellius, J. & Aisien , M.S.O. (1994). Trypanosome -lectin interactions. In: Lectin -microorganism Interaction s (Doyle, R.J. and Slifkin, M. eds), pp. 225 -247. Marcel Dekker, New York, Basel and Hong Kong." 1598 1816 W4323022800.pdf 1 24 separator 0.9779037 ¶ ¶ 1818 1824 W4323022800.pdf 1 25 title 0.88162225 Conference Proceedings 1824 1847 W4323022800.pdf 1 26 separator 0.9742402 ¶ 1849 1851 W4323022800.pdf 1 27 bibliography 0.994823 "Anoliefo, G.O . (2002). Ecological methods of reclamation of oil polluted lands. Proceedings of the Expert Group Meeting on Pollution and Sediment Sources in the Nigerian Inland Waterways and Strategies for their Management. UNDP Sponsored International Conference on St rategies for the Management of Pollution and Sedimentation in the Nigerian Inland Waterways, Lokoja, Nigeria. October, 2324, pp. 255 -267." 1851 2274 W4323022800.pdf 1 28 separator 0.98946905 ¶ ¶ 2275 2281 W4323022800.pdf 1 29 title 0.93162036 Theses 2281 2288 W4323022800.pdf 1 30 separator 0.9779257 ¶ 2290 2292 W4323022800.pdf 1 31 bibliography 0.9945461 "Edo-Taiwo, O. (2018). Amphibian diversity and parasitic infections in relation to pesticide exposure at Ugboke (plantations and settlement), Ovia South -West LGA, Edo State, Nigeria." 2292 2481 W4323022800.pdf 1 32 separator 0.6758046 ¶ 2482 2484 W4323022800.pdf 1 33 bibliography 0.89210474 Ph.D Thesis, University of Benin, Benin City, Nigeria 2484 2538 W4323022800.pdf 1 34 separator 0.81976986 ¶ ¶ 2540 2546 W4323022800.pdf 1 35 text 0.354639 NOTE 2546 2551 W4323022800.pdf 1 36 contact 0.39727816 : 2551 2552 W4323022800.pdf 1 37 text 0.36513463 Other vital instructions 2552 2577 W4323022800.pdf 1 38 contact 0.4109389 to 2577 2580 W4323022800.pdf 1 39 text 0.44174114 author can be found at: 2580 2604 W4323022800.pdf 1 40 contact 0.33831066 2606 2607 W4323022800.pdf 1 41 text 0.2642575 ¶ 2607 2608 W4323022800.pdf 1 42 contact 0.4114859 https 2608 2614 W4323022800.pdf 1 43 text 0.3726937 :// 2614 2617 W4323022800.pdf 1 44 contact 0.36923903 uniben 2617 2623 W4323022800.pdf 1 45 text 0.35197985 l 2623 2624 W4323022800.pdf 1 46 contact 0.3494109 si.org.ng/ 2624 2634 W4323022800.pdf 1 47 text 0.33443183 index 2634 2639 W4323022800.pdf 1 48 contact 0.33132982 . 2639 2640 W4323022800.pdf 1 49 text 0.3705626 php 2640 2643 W4323022800.pdf 1 50 contact 0.28342414 / 2643 2644 W4323022800.pdf 1 51 text 0.3436057 njls 2644 2648 W4323022800.pdf 1 52 contact 0.3120804 / 2648 2649 W4323022800.pdf 1 53 text 0.3128223 njls 2649 2653 W4323022800.pdf 1 54 contact 0.33486378 for 2653 2657 W4323022800.pdf 1 55 text 0.289743 authors 2657 2665 W4323022800.pdf 1 0 title 0.98735946 What wecan and cannot sayabout thefuture climate 0 48 W2811044906.pdf 1 1 separator 0.99474025 ¶ 48 50 W2811044906.pdf 1 2 text 0.9996055 "Uncertainty inclimate change prediction arises from multiple sources: (1)animperfect ability tomeasure and initialize simulations with thecurrent state oftheclimate system, atmospheric greenhouse gas,and aerosol concentrations (`initial conditions'); (2)uncertainty about the anticipated future trajectory ofgreenhouse gasand aerosol emissions; (3)climate model errors leading touncertainty about how theclimate system willrespond tothisexternal forcing; and (4)natural climate variability. Toquantify thelikelihood ofdifferent climate futures, multiple model simulations arerun, which attempt tosample therange ofprediction uncertainty aris- ingfrom these different sources. These simulations assume different emissions trajectories, use arange ofclimate models, and areinitialized using slightly perturbed initial conditions tosee how each ofthese factors contributes tothetotal uncertainty. The spread ofprojected out- comes istaken asanindication oftheuncertainty, and probabilities areassigned tooutcomes according tohow frequently they occur within theensemble. The problem isthat itisimpossi- bletosample thefullrange ofuncertainty within such anensemble ofprojections [8,9]. Differ- ences inprojections among models areexamined closely, buttheensemble ofavailable models isadhocand cannot beexpected toprovide areliable estimate oftherange offutures that might plausibly occur. Moreover, without past testcases over which tocalibrate theensemble projections, itisimpossible toknow whether probabilistic climate change projections arereli- able [8]." 50 1641 W2811044906.pdf 1 3 separator 0.9878269 ¶ 1641 1643 W2811044906.pdf 1 4 text 0.99970573 "These limitations pertain toprojections offuture climate change atanyscale. Obtaining information atlocal scales and atspecific points inthefuture gives risetoanumber ofaddi- tional issues, which areoften overlooked instudies projecting future health impacts. Scientists have high confidence inseveral aspects oflarge-scale climate change, including, forexample, global warming and large-scale temperature trends and sealevel rise. However, themodels have many documented limitations, particularly regarding their ability tocapture extremes, which areoften ofmost interest forimpacts [10]. Projections among models candiffer dramat- ically, especially onscales smaller than continents and even forthedirection ofchange inrain- fallinmany parts oftheworld [11]. Downscaled climate information may appear tobea solution, astheoutput ofthisprocess delivers information that appears more realistic because ofitshigher resolution. However, regional downscaling cannot rectify many oftheproblems with global models and cangive afalse impression ofconfidence [12]." 1643 2723 W2811044906.pdf 1 5 separator 0.98826736 ¶ 2723 2725 W2811044906.pdf 1 6 text 0.9997429 "Ofallthechallenges associated with predicting climate change impacts, thenatural variabil- ityoftheclimate system isperhaps themost overlooked. Unlike weather orseasonal forecasts, which areinitialized with current weather and climate observations, climate change projec- tions areuninitialized. The models areable toreproduce keymodes ofnatural climate variabil- ityoninterannual and decadal timescales, butwithout initialization, thetiming ofthese cycles does notcoincide with therealworld. Initialised decadal predictions offer promise, butthey arecurrently experimental and donotperform well enough toinform decision-making directly, particularly onlocal scales and forprecipitation [13]. Interannual fluctuations are, overwhelmingly, thelargest contributor tototal climate variability forboth rainfall and tem- perature. Decadal variability canbesignificant aswell. Forexample, East Africa hasexperi- enced adecline inrainfall since thelate1990s despite long-term projections suggesting that theregion isheading forwetter conditions bytheend ofthecentury [14]. The `global warming hiatus', when upward temperature trends stalled atthebeginning thiscentury, isanother example [15]. The science behind global warming isunequivocal, buttheexpectation that the temperature willbehotter attheend ofthecentury says nothing about thetrajectory between now and thelong-term future. Failure toconsider these fluctuations could have major conse- quences foradaptation planning, particularly when looking atthenext 10to30years [16]." 2725 4284 W2811044906.pdf 1 7 separator 0.9598147 ¶ 4284 4286 W2811044906.pdf 1 8 paratext 0.9882366 PLOS Medicine |https://doi.or g/10.1371/ journal.pmed.1 002624 July 31,2018 2/5 4286 4366 W2811044906.pdf 1 0 paratext 0.9005505 7 0 1 W2895264839.pdf 6 1 separator 0.98541224 ¶ 1 3 W2895264839.pdf 6 2 text 0.9988792 "www.eurosurveillance.orgrespectively. Based on visual inspection this seemed to generate the most relevant signals, as well as provide a sample size large enough for meaningful statistics over a period of time that was short enough to account for the changing population of the MedPoints. As some MedPoints were closed during the weekends or oper - ated just 2 days a week, some days had no counts (number of times a given syndrome was reported on a given day). Therefore, the quantities were computed over less than d data points, typically 15 days for the default d = 21 (for MedPoints working 5 days a week)." 3 647 W2895264839.pdf 6 3 separator 0.8962178 ¶ 648 650 W2895264839.pdf 6 4 text 0.9994995 "The values of these parameters could be set in order to optimise the trade-off between sensitivity and speci - ficity, depending on the symptoms and the experi - ence of the HCW. For acute respiratory infections and ‘other non-communicable diseases’ we set the value to n = 4; n and d were set to the standard values for the other syndromes." 650 1010 W2895264839.pdf 6 5 separator 0.9108888 ¶ 1010 1012 W2895264839.pdf 6 6 text 0.9996883 "Two additional parameters allowed for further flexibil - ity. First, the minimum daily count needed for a signal to be generated and second, a fixed threshold above which signals were always generated. They were respec - tively set to 1 and infinity by default. For instance, a low number of acute respiratory infections might be statis - tically but not epidemiologically relevant, so that only a daily count strictly above three cases could gener - ate a signal. On the other hand, for some syndromes a single case was considered remarkable enough that it always triggered a signal; this was the case for chronic cough, varicella, measles, fever with rash, meningitis, bloody diarrhoea, jaundice, death or severe infection." 1012 1767 W2895264839.pdf 6 7 separator 0.99320805 ¶ 1768 1770 W2895264839.pdf 6 8 title 0.4263718 1770 1771 W2895264839.pdf 6 9 text 0.6053892 Examples of count time series, thresholds, and signals 1771 1825 W2895264839.pdf 6 10 separator 0.85647774 ¶ 1826 1828 W2895264839.pdf 6 11 text 0.9985768 "are shown in Figure 1 . These analysis and visualisa - tions were carried out once the data were entered in an Excel document. Signals were visualised inside the Excel sheet as red marks [ 22]. All unusual syndrome clusters or single events with potentially high trans - mission risk were immediately communicated to the MedPoints for outbreak verification." 1828 2203 W2895264839.pdf 6 12 separator 0.96547604 ¶ 2204 2206 W2895264839.pdf 6 13 text 0.9981565 "Our SySu toolkit is available at [ 22]. It consists of: (i) a data collection sheet, (ii) a Microsoft Excel (Microsoft Corporation, Redmond, Washington) file for cluster analysis consisting of sheets for data entry, indication of signals, plots, tables and a sheet for setting param - eters and, (iii) supporting material for public health management of ID. The tool allows users to enter, Figure 3" 2206 2622 W2895264839.pdf 6 14 separator 0.9963974 ¶ 2622 2624 W2895264839.pdf 6 15 title 0.94219303 "Number of laboratory confirmed or clinically diagnosed notified outbreak cases in mass accommodations, Berlin, Germany, week 40/2015-week 13/2017" 2624 2773 W2895264839.pdf 6 16 table 0.9452257 "¶ 0510152025303540 40424446485052 13579111315171921232527293133353739414345474951 135791113 2015 2016 2017Number of reported casesRespiratory infections Varicella and MeaslesGastrointestinal infections Other infections Syndromic surveillance period CW17/2016 CW17/2016 Time (week, year)" 2773 3074 W2895264839.pdf 6 17 separator 0.87692654 ¶ 3074 3076 W2895264839.pdf 6 18 caption 0.5097465 Data source: SurvNet (database of the German notification system at the Robert 3076 3155 W2895264839.pdf 6 19 text 0.42389745 Koch Institute 3155 3170 W2895264839.pdf 6 20 caption 0.44142404 ). 3170 3172 W2895264839.pdf 6 21 separator 0.9528411 ¶ 3172 3174 W2895264839.pdf 6 22 caption 0.5595269 The figure is 3174 3188 W2895264839.pdf 6 23 text 0.5090572 3188 3189 W2895264839.pdf 6 24 caption 0.48854348 based 3189 3194 W2895264839.pdf 6 25 text 0.63884914 on the 3194 3201 W2895264839.pdf 6 26 caption 0.48552838 method 3201 3208 W2895264839.pdf 6 27 text 0.6213224 for 3208 3213 W2895264839.pdf 6 28 caption 0.4699165 identification 3213 3227 W2895264839.pdf 6 29 text 0.57291186 of asylum seekers 3227 3245 W2895264839.pdf 6 30 caption 0.5213659 in 3245 3248 W2895264839.pdf 6 31 text 0.60654974 German 3248 3256 W2895264839.pdf 6 32 caption 0.50934476 notification data 3256 3273 W2895264839.pdf 6 33 text 0.6963839 described by Kuehne et al. 2016 [24]. 3273 3311 W2895264839.pdf 6 0 paratext 0.9906361 Page 13 of 15 0 13 W4306695888.pdf 12 1 separator 0.7211535 ¶ 13 15 W4306695888.pdf 12 2 paratext 0.9810449 Jiang et al. European Journal of Medical Research (2022) 27:205 16 89 W4306695888.pdf 12 3 separator 0.9668606 ¶ ¶ 90 96 W4306695888.pdf 12 4 title 0.9866766 Discussion 96 107 W4306695888.pdf 12 5 separator 0.9934766 ¶ 107 109 W4306695888.pdf 12 6 text 0.99132913 "STAD is one of the most common malignant tumors of the digestive system, and its morbidity and mortality are among the highest among all cancers in the world. The genesis and development of STAD is a complex multi-stage process involving many genetic and epige - netic changes. The effectiveness and strategies of cancer therapy often depend on the stage of cancer diagnosed." 109 502 W4306695888.pdf 12 7 separator 0.6970732 ¶ 503 505 W4306695888.pdf 12 8 text 0.9995743 "The diagnosis of STAD is most usually in the advanced stage, which leads to difficult diagnosis, poor prognosis, and high mortality. Patients with early-stage STAD can be cured and have a good prognosis, but the early-stage diagnosis of STAD is very challenging because it is gen - erally mild or asymptomatic. Molecular markers based on coding or non-coding genes have great potential in predicting the prognosis of cancers. The development of molecular markers that can effectively identify early- stage STAD and have good prognostic effect is crucial for the therapy strategy and effect of STAD." 505 1129 W4306695888.pdf 12 9 separator 0.96739805 ¶ 1129 1131 W4306695888.pdf 12 10 text 0.99892104 "In this study, the gene expression profiles of STAD samples and patients’ clinical factors were retrieved from TCGA and GEO public databases with bioinformatics methods. A total of 569 early-stage specific genes were identified by mining the differentially expressed genes in the early-stage of STAD. Enrichment analysis showed that these early-stage STAD specific DEGs were mainly involved in cytokine–cytokine receptor interaction, neuroactive ligand–receptor interaction, and calcium signal pathway. Then, univariate and multivariate Cox proportional hazard regression analysis of the early-stage" 1131 1761 W4306695888.pdf 12 11 separator 0.9944493 ¶ 1762 1764 W4306695888.pdf 12 12 caption 0.9928032 "Fig. 9 Functional enrichment and annotation analysis of DEGs between the high- and low-risk groups by the 10-mRNA signature. A The bar plots showing GO enrichment analysis; B the significant GO terms associated with the DEGs. C The dot plots showing KEGG pathway enrichment analysis. p-value less than 0.05 indicated a significant enrichment term" 1764 2117 W4306695888.pdf 12 0 text 0.99935704 "variant CoAM or CoAZ, respectively, through shared func- tional domains (Fig. 4 A). Their overall expression levels and alternative splicing balance are further subjected to regulationby yet another non-coding variant, ncCoAZ, which is efficientlyproduced by trans -splicing." 0 279 W1972250756.pdf 10 1 separator 0.97940195 ¶ 279 281 W1972250756.pdf 10 2 text 0.9997086 "To test this model on a physiological target gene, we chose to analyze Tau, as RBM4 has been previously identified by anothergroup through a library screen that binds to Tau mRNA andpromotes Tau exon 10 inclusion (29). The microtubule-associ-ated protein Tau is important for neuronal function. Exon 10inclusion or skipping of Tau produces spliced isoforms whoseimbalance is associated with multiple neurodegenerative dis-eases collectively called “tauopathies” (35). We then tested ifCoAA and the variants also regulate Tau exon 10. PCR primerswere designed on exon 9 and 11 for total Tau mRNA expressionand on exon 10 and 11 for exon inclusion only (Fig. 7 D). Con- sistent with the previous findings that the fetus has more exonskipping and the adult has more exon inclusion (43), RT-PCRand real-time quantification showed that the endogenous Tauexon 10 inclusion gradually decreased and then increased dur-ing P19 cell differentiation (Fig. 7 D,left panel ). The total amount of Tau expression peaked in parallel with MAP-2 (Fig.6A), suggesting that Tau may be involved in neuronal functions." 281 1384 W1972250756.pdf 10 3 separator 0.9789276 ¶ 1384 1386 W1972250756.pdf 10 4 text 0.9997409 "We then overexpressed CoAA, RBM4, and their variantsCoAM, CoAZ, and ncCoAZ in undifferentiated P19 stem cells.The vector was a control representing the endogenous Tau lev-els. The results indicated that CoAA and CoAZ promoted exon10 skipping. RBM4, CoAM, and ncCoAZ promoted exon 10inclusion (Fig. 7 D,right panel ). In neurons, balanced Tau splic- ing may be maintained by both CoAA and RBM4, which arepresent in the cortical plate (Fig. 5 B). During gliogenesis, the absence of CoAA and the presence of RBM4 in subpopulationsof astrocytes (Fig. 5 F) may explain the increased Tau exon 10 inclusion at the late stage of P19 cell differentiation. The datatogether suggested that CoAA and RBM4 counter-regulate Tauexon 10 splicing. The differential expression of CoAA, RBM4,and their variants potentially contribute to cell-specific expres-sion of Tau isoforms." 1386 2253 W1972250756.pdf 10 5 separator 0.98835576 ¶ 2253 2255 W1972250756.pdf 10 6 text 0.99968785 "Using stably transfected stem cells, we further investigated CoAA, RBM4, and their variants in embryoid body formation.The choice of stable overexpression rather than small interfer-ing RNA (siRNA) knockdown was made because of the lack ofsequence specificity for small interfering RNA siRNA in over-lapped variants. The constant overexpression by the CMV pro-moter would disrupt the switched expression patterns requiredfor embryoid body formation. Compared with the vector con-trol, the stable CoAA, CoAM, RBM4, and ncCoAZ cells haddefects in formation of embryoid bodies (Fig. 8 A). Stable CoAZ cells did not significantly affect the formation of embryoid bod-ies possibly because of the requirement of CoAZ in a later stageof differentiation. The results for each transfected stable cellwere consistently seen in more than two selected stable clones.The vector control showed no detectable difference fromuntransfected cells in the aspects of embryoid body formationor marker gene expression (not shown). When marker geneexpression was analyzed by PCR, the results showed the alteredexpression levels in both neural lineage markers MAP-2, GFAP,and Tau as well as non-neural lineage markers Nanog and Sox6(Fig. 8 B). In particular, the expression of Tau was elevated before retinoic acid induction in CoAA CoAM, ncCoAZ, andRBM4 stable cells. The exon 10 inclusion of Tau was increasedin ncCoAZ and RBM4 stable cells. The data were confirmed byquantitative PCR analysis (Fig. 8 B). Although the stable expres- sion did not reflect physiological conditions, the data impli-cated that the balance of CoAA and RBM4 and their variants isinvolved in controlling stem/progenitor cell differentiation.Because CoAA and RBM4 are coregulators in multiple tissues,their target genes may include neural lineage genes such as Taubut may not be limited to neural lineage. The imbalance ofCoAA and RBM4 activities through the control of their variantscan disrupt normal differentiation program." 2255 4245 W1972250756.pdf 10 7 separator 0.9927802 ¶ 4245 4247 W1972250756.pdf 10 8 title 0.99214894 DISCUSSION 4247 4258 W1972250756.pdf 10 9 separator 0.9958775 ¶ 4258 4260 W1972250756.pdf 10 10 text 0.9997621 "In this study we have identified trans -splicing events between the CoAA andRBM4 genes, which yield a novel zinc finger-containing coactivator CoAZ and a non-coding splicevariant ncCoAZ. Based on the collective evidence, we propose amodel in which the C-terminal activation domain of CoAAstimulates transcription and the C-terminal zinc finger domainof RBM4 represses transcription. RBM4 competes with CoAAthrough highly homologous double RRM domains at their Ntermini, which might be responsible for the pre-mRNA inter-action during transcription-coupled alternative splicing.CoAM, an alternative splice variant containing only the doubleRRMs of CoAA, has been previously shown to repress CoAAactivity. CoAZ contains an intact RBM4 zinc finger but defec-tive double RRMs and, thus, competes with RBM4 to indirectlyfacilitate the CoAA activity. ncCoAZ, although producing noprotein product, regulates both CoAA and RBM4 expressionvia competitive splicing or by participates in potentially uni-dentified downstream RNA metabolism that impacts bothCoAA and RBM4 transcripts. Thus, coactivator CoAA, core-pressor RBM4, and their splice variants CoAM, CoAZ, andncCoAZ have established a linked control because of the pres-ence of alternative splicing and trans -splicing. When they are specifically expressed in different cell lineages, alternative splic-ing or trans- splicing would constitute a mechanism in regulat- ing the coregulator balance in each cell lineage." 4260 5733 W1972250756.pdf 10 11 separator 0.98694646 ¶ 5733 5735 W1972250756.pdf 10 12 text 0.99961984 "The phenomenon of trans -splicing has been found in a vari- ety of organisms including trypanosomes (44), Caenorhabditis elegans (45), euglenoids (46), flatworms (47), Drosophila (48), and mammals (49). It is frequently found within a cluster ofgenes using canonical splice sites and generating translatablemRNA (40). In mammals, the consecutive arrangement of thethree genes CoAA (RBM14 ),RBM4 , and RBM4B is highly con- served. All three genes encode RRM-containing proteins andfunction as alternative splicing regulators. Our study on trans - splicing between CoAA andRBM4 implies that these genes are associated as a gene cluster and share a common enhancersequence. Expressed sequence tag evidence also supports thepresence of splicing events between RBM4 and RBM4B , although at a lower frequency ( supplemental Fig. 1). The RBM4B gene encodes an RBM4 isoform (30), and both proteins are mammalian orthologs of the Drosophila protein Lark (32), which was originally identified in Drosophila circadian rhythm regulation and early development (34). We performed a phylo-trans-Splicing Variants of CoAA and RBM4" 5735 6872 W1972250756.pdf 10 13 separator 0.97273374 ¶ 6872 6874 W1972250756.pdf 10 14 paratext 0.9764405 JULY 3, 2009• VOLUME 284 • NUMBER 27 JOURNAL OF BIOLOGICAL CHEMISTRY 18043 6874 6949 W1972250756.pdf 10 0 bibliography 0.98588306 "¶ therapy on homocysteine, vitamin B 12 and folic acid levels in children with epilepsy. Indian Pediatr. 2013; 50: 469-72." 1 129 W2561400036.pdf 3 1 separator 0.9893111 ¶ 131 133 W2561400036.pdf 3 2 bibliography 0.99773145 "16. Aslan K, Bozdemir H, Unsal C, Guvenc B. The effect of antiepileptic drugs on vitamin B 12 metabolism. Int J Lab Hematol. 2008; 30: 26-35." 133 281 W2561400036.pdf 3 3 separator 0.9841386 ¶ 283 285 W2561400036.pdf 3 4 bibliography 0.9972724 "17. El Dayem SMA, Saleh ON, Emara NA, Kandil ME, Shatla RH, Elgammal S. Evaluation of homo- cysteine, folic acid and vitamin B 12 levels among egyptian children with idiopathic epilepsy. Maced J Med Sci. 2014; 7: 109-13. 18. Dastur DK, Dave UP. Effect of prolonged anticonvulsant medication in epileptic patients: Serum lipids, vitamins B 6, B 12, and folic acid, proteins, and fine structure of liver. Epilepsia 1987; 28: 147-59." 285 739 W2561400036.pdf 3 5 separator 0.98251796 ¶ 740 742 W2561400036.pdf 3 6 bibliography 0.99765515 "19. Frank O, Baker H, Leavy CM. Vitamin binding capacity of experimentally injured liver. Nature 1964; 203: 302-03." 742 865 W2561400036.pdf 3 7 separator 0.9717021 ¶ 868 870 W2561400036.pdf 3 8 bibliography 0.9971943 "20. Clinical laboratory and standards institute. How to define and determine reference intervals in the clinical laboratory: Approved Guideline. 2nd ed." 870 1029 W2561400036.pdf 3 9 separator 0.51601595 ¶ 1030 1032 W2561400036.pdf 3 10 bibliography 0.9975731 CLSI document C28-A2. Wayne, PA, 2000, p 24. 1032 1077 W2561400036.pdf 3 11 separator 0.98723114 ¶ 1078 1080 W2561400036.pdf 3 12 paratext 0.54396796 226 BSMMU 1081 1091 W2561400036.pdf 3 13 bibliography 0.50037354 J 1091 1093 W2561400036.pdf 3 14 paratext 0.6753054 2016; 9: 223-226 1093 1110 W2561400036.pdf 3 0 paratext 0.9660792 "International Journal of Electrical and Electronics Research ISSN 2348 -6988 (online) Vol. 10, Issue 4, pp: (33 -37), Month: October - December 2022, Available at: www.researchpublish.com ¶ Page | 36" 0 213 W4313204590.pdf 3 1 separator 0.6162117 ¶ 214 216 W4313204590.pdf 3 2 paratext 0.93059576 Research Publish Journals 216 242 W4313204590.pdf 3 3 title 0.431869 244 245 W4313204590.pdf 3 4 math 0.96117216 "Proof Since ( I [Γ(α+1)]1 αxα)[ (1 Γ(α+1)xα)⨂i ] =1 i+1(1 Γ(α+1)xα)⨂(i+1) −1 i+1 =1−i 2[(1 Γ(α+1)xα)⨂(1 Γ(α+1)xα)⨂i ]−1−i 2 =1−i 2[(1 Γ(α+1)xα)⨂[cos α(Lnα(xα))+isin α(Lnα(xα))]]−1−i 2 (by Lemma 3.1) =1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))+cos α(Lnα(xα))]−1] +i1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))−cos α(Lnα(xα))]+1] . (25) And ( I [Γ(α+1)]1 αxα)[ (1 Γ(α+1)xα)⨂i ] = ( I [Γ(α+1)]1 αxα)[cos α(Lnα(xα))+isin α(Lnα(xα))] = ( I [Γ(α+1)]1 αxα)[cos α(Lnα(xα))]+i( I [Γ(α+1)]1 αxα)[sin α(Lnα(xα))] . (26)" 245 1133 W4313204590.pdf 3 5 separator 0.979244 ¶ 1134 1136 W4313204590.pdf 3 6 math 0.50960505 It follows that 1136 1152 W4313204590.pdf 3 7 separator 0.46788174 ¶ 1154 1156 W4313204590.pdf 3 8 math 0.95187014 "( I [Γ(α+1)]1 αxα)[cos α(Lnα(xα))]=1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))+cos α(Lnα(xα))]−1], and ( I [Γ(α+1)]1 αxα)[sin α(Lnα(xα))]=1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))−cos α(Lnα(xα))]+1]." 1156 1367 W4313204590.pdf 3 9 separator 0.8122318 ¶ 1368 1370 W4313204590.pdf 3 10 math 0.78063625 Q.e.d. 1528 1535 W4313204590.pdf 3 11 separator 0.98497164 ¶ 1537 1539 W4313204590.pdf 3 12 text 0.96087253 Remark 3.3: By product rule for fractional derivatives, we have 1539 1604 W4313204590.pdf 3 13 separator 0.65281445 ¶ 1606 1608 W4313204590.pdf 3 14 math 0.9559449 "( D [Γ(α+1)]1 αxα)[1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))+cos α(Lnα(xα))]−1]] =1 2[sin α(Lnα(xα))+cos α(Lnα(xα))]+1 2[cos α(Lnα(xα))−sin α(Lnα(xα))] =cos α(Lnα(xα)). (27) And ( D [Γ(α+1)]1 αxα)[1 2[(1 Γ(α+1)xα)⨂[sin α(Lnα(xα))−cos α(Lnα(xα))]+1]] =1 2[sin α(Lnα(xα))−cos α(Lnα(xα))]+1 2[cos α(Lnα(xα))+sin α(Lnα(xα))] =sin α(Lnα(xα)). (28)" 1631 2361 W4313204590.pdf 3 15 separator 0.97584695 ¶ 2362 2364 W4313204590.pdf 3 16 text 0.9880452 Therefore, we can easily know that Theorem 3.2 holds. 2364 2419 W4313204590.pdf 3 17 separator 0.9968424 ¶ 2421 2423 W4313204590.pdf 3 18 title 0.9911852 IV. CONCLUSION 2423 2441 W4313204590.pdf 3 19 separator 0.9967675 ¶ 2443 2445 W4313204590.pdf 3 20 text 0.98237425 "In this paper, we solve two types of fractional integrals based on Jumarie ’s modified R-L fractional integral . A new multiplication of fractional analytic functions , complex power of fractional analytic function, and product rule for fractional" 2445 2698 W4313204590.pdf 3 0 paratext 0.99127764 Page 4 of 9 0 11 W4391513641.pdf 3 1 separator 0.7292007 ¶ 11 13 W4391513641.pdf 3 2 paratext 0.97875255 Xie et al. Reproductive Biology and Endocrinology (2024) 22:19 13 87 W4391513641.pdf 3 3 separator 0.98562825 ¶ 88 90 W4391513641.pdf 3 4 text 0.9972926 "and pregnancy was 4.0 months (95% CI: 3.0–5.0 months), whereas in the Non-oil-based group, it was 6.0 months (95% CI: 5.0–7.0 months). The cumulative clinical preg - nancy rate demonstrated a significant increase in the Oil-based group compared to the Non-oil-based group according to the rank sum test ( p = 0.014, Fig. 2)." 90 430 W4391513641.pdf 3 5 separator 0.9962332 ¶ 430 432 W4391513641.pdf 3 6 title 0.9912766 Stratified analysis using additional factors 432 477 W4391513641.pdf 3 7 separator 0.9931127 ¶ 477 479 W4391513641.pdf 3 8 text 0.9995739 "To assess potential variations in the relationship between the contrast medium and pregnancy outcome, a stratified study was conducted in multiple subgroups. Stratification was performed based on age, BMI, complications, and treatment following HSG. Our findings indicate that the fertility-enhancing effect of the oil-based contrast agent is consistent across different age groups, BMI categories, the absence of complications, and among patients under - going expectant treatment. Conversely, in patients with complications, those undergoing intrauterine insemina - tion (IUI), in vitro fertilization (IVF), and combined lapa - roscopy/hysteroscopy procedures after the contrast agent administration, we did not observe the same fertility- enhancing effect,, as illustrated in Fig. 3." 479 1299 W4391513641.pdf 3 9 separator 0.9967289 ¶ 1299 1301 W4391513641.pdf 3 10 title 0.98662233 Discussion 1301 1312 W4391513641.pdf 3 11 separator 0.9941394 ¶ 1312 1314 W4391513641.pdf 3 12 text 0.9995516 "In this retrospective investigation, we found that among infertile women affected by endometriosis who under - went HSG with oil contrast, the rate of clinical pregnancy within a year following the procedure was significantly higher compared to those who underwent the procedure without it. Additionally, women subjected to HSG with oil contrast exhibited a markedly elevated rate of subse - quent live births." 1314 1744 W4391513641.pdf 3 13 separator 0.9802405 ¶ 1744 1746 W4391513641.pdf 3 14 text 0.99958646 "Research has consistently demonstrated that the use of oil-based contrast agents during HSG contributes to improved fertility. Notably, findings from the water vs. oil (H2Oil trial) indicate that the oil-based group exhibited a higher rate of live births (38.8% vs. 28.1%) and sustained pregnancies (39.7% vs. 29.1%) compared to the water- based group [ 3]. Another Randomized Controlled Trial (RCT) reported that the oil group not only experienced" 1746 2215 W4391513641.pdf 3 15 separator 0.7501617 ¶ 2216 2218 W4391513641.pdf 3 16 caption 0.9950308 Fig. 1 Flowchart of study recruitment and inclusion/exclusion criteria 2218 2290 W4391513641.pdf 3 0 text 0.9927297 "12 months [32, 34 –37]. With regard to the type of inter- vention, the core of the selected articles was centered on resistance training exercises [13, 31 –38] (Table 2)." 0 174 W2184534016.pdf 4 1 separator 0.9964689 ¶ 174 176 W2184534016.pdf 4 2 title 0.9893432 Intervention characteristics 176 205 W2184534016.pdf 4 3 separator 0.99455154 ¶ 205 207 W2184534016.pdf 4 4 text 0.9576495 "The intervention characteristics are summarized in Table 2. Six studies included multi component exerciseinterventions [13, 32 –35, 38]. In two of these six studies, the intervention program involved progressive resistance exercise training (PRT) [13, 38]: one used an interven- tion home program of balance and strength, based on the Weight-bearing for Better Balance (WEBB) program [33]; one investigated two exercise programs, functional walking, consisting of exercises related to daily mobility" 207 721 W2184534016.pdf 4 5 caption 0.94143754 Fig. 1 Flow diagram of study selectionde Labra et al. BMC Geriatrics (2015) 721 797 W2184534016.pdf 4 6 paratext 0.86672944 15:154 Page 5 of 16 797 817 W2184534016.pdf 4 0 paratext 0.97085416 "Mamani-Benito et al. 10.3389/feduc.2024.1297302 Frontiers in Education 04 frontiersin.org2" 0 94 W4393273489.pdf 3 1 title 0.876836 Methods 94 102 W4393273489.pdf 3 2 separator 0.98925704 ¶ 102 104 W4393273489.pdf 3 3 title 0.9899019 2.1 Design and participants 104 132 W4393273489.pdf 3 4 separator 0.9939765 ¶ 132 134 W4393273489.pdf 3 5 text 0.9996115 "Similar to other studies conducted in the context of the COVID-19 pandemic ( Carranza et al., 2022 ), the present research is classified as an explanatory cross-sectional study ( Ato et al., 2013 ). This means an associative strategy was employed (allowing exploration of the functional relationship between variables) under a design that tests theoretical models about the relationships among a set of variables, as derived from an underlying theory. Utilizing non-probabilistic convenience sampling, 1,321 Peruvian university students participated (52.1% women), ranging in age from 18 to 35 ( M = 20.16, SD = 3.04)." 134 777 W4393273489.pdf 3 6 separator 0.77152455 ¶ 778 780 W4393273489.pdf 3 7 text 0.9995332 "Of these, 76.2% attend a private university, while 23.8% attend a state university. The majority, 88.7%, reside in the highlands. Students’ fields of study include 25.3% in business science, 24.1% in engineering and architecture, 22.4% in health sciences, and 14.8% in humanities and education." 780 1087 W4393273489.pdf 3 8 separator 0.7992618 ¶ 1087 1089 W4393273489.pdf 3 9 text 0.99910146 "Given the nature of the sample, inclusion criteria for this study were set as being a student at a private university, of Peruvian nationality, and providing consent (participating voluntarily)." 1089 1290 W4393273489.pdf 3 10 separator 0.72509336 ¶ 1291 1293 W4393273489.pdf 3 11 text 0.99933994 "Participants were contacted through social networks (Facebook and WhatsApp); in this case, there was no incentive to participate in the study. Instead, the invitation was open, and voluntary participation was sought." 1293 1519 W4393273489.pdf 3 12 separator 0.99701536 ¶ 1519 1521 W4393273489.pdf 3 13 title 0.99140406 2.2 Instruments 1521 1537 W4393273489.pdf 3 14 separator 0.9948431 ¶ 1537 1539 W4393273489.pdf 3 15 title 0.97883874 2.2.1 Emotional fatigue 1539 1563 W4393273489.pdf 3 16 separator 0.99189097 ¶ 1563 1565 W4393273489.pdf 3 17 text 0.9996986 "The Emotional Fatigue Scale (EFS; Dominguez Lara, 2013 ) was used. The EFS consists of 10 items with Likert response options ranging from strongly disagree to strongly agree. In this study, the EFS demonstrated good internal consistency ( ω = 0.91). In this study, the EFS showed good internal consistency ( ω = 0.91). This instrument has been used in studies within the context of the COVID-19 pandemic (Carranza et al., 2023 )." 1565 2013 W4393273489.pdf 3 18 separator 0.9973288 ¶ 2013 2015 W4393273489.pdf 3 19 title 0.9917367 2.2.2 Satisfaction with studies 2015 2047 W4393273489.pdf 3 20 separator 0.9937134 ¶ 2047 2049 W4393273489.pdf 3 21 text 0.999749 "The Brief Satisfaction with Studies Scale (BSSS; Merino-Soto et al., 2017 ) was used. The BSSS assesses student satisfaction with their study habits and academic performance. It has 3 items with a 1 to 5 Likert response format (strongly disagree, disagree, neither agree nor disagree, agree, strongly agree). In the current research, the Cronbach’s alpha coefficient value estimating reliability was good ( ω = 0.82). This instrument has also been used in studies related to the COVID-19 pandemic ( Carranza et al., 2022 )." 2049 2591 W4393273489.pdf 3 22 separator 0.997266 ¶ 2591 2593 W4393273489.pdf 3 23 title 0.99261993 2.2.3 Academic engagement 2593 2619 W4393273489.pdf 3 24 separator 0.9951187 ¶ 2619 2621 W4393273489.pdf 3 25 text 0.9997422 "Academic Engagement Scale (UWES S9), adapted to Peru by Dominguez-Lara et al. (2020) consists of 9 items distributed across two factors. It offers 7 Likert response options ranging from never to always. In this study, the UWES S9 displayed good internal consistency (ω = 0.89). This instrument has been utilized in studies concerning the COVID-19 pandemic ( Dominguez-Lara et al., 2023 )." 2621 3026 W4393273489.pdf 3 26 separator 0.9971237 ¶ 3026 3028 W4393273489.pdf 3 27 title 0.9901774 2.3 Procedure 3028 3042 W4393273489.pdf 3 28 separator 0.99546957 ¶ 3042 3044 W4393273489.pdf 3 29 text 0.9996268 "The COVID-19 pandemic necessitated the use of technological resources. In this light, to reach a broader range of students (engaging a large number of participants), ensure ease of use, and facilitate rapid communication, a virtual survey was set up using Google Forms. The link was disseminated via social networks (Facebook and WhatsApp) and was active between March and April 2023. The informed consent was presented at the beginning of the questionnaire along with the study’s objective, stating that participation was voluntary and anonymous. Furthermore, all ethical research principles involving humans, as outlined in the Helsinki declaration, were adhered to." 3044 3743 W4393273489.pdf 3 30 separator 0.9972061 ¶ 3743 3745 W4393273489.pdf 3 31 title 0.98992985 2.4 Data analysis 3745 3763 W4393273489.pdf 3 32 separator 0.99469393 ¶ 3763 3765 W4393273489.pdf 3 33 text 0.99967605 "The study model was analyzed using structural equation modeling with the MLR estimator, which is employed for numerical variables and is robust to inferential normality deviations ( Muthén and Muthén, 2017 ). The fit evaluation was conducted using the Comparative Fit Index (CFI), the Root Mean Square Error of Approximation (RMSEA), and the Standardized Root Mean Square Residual (SRMR). CFI values >0.90 ( Bentler, 1990 ), RMSEA <0.080, and SRMR <0.080 ( Browne and Cudeck, 1992 ) were used. For reliability analysis, the internal consistency alpha ( α) method was employed. The data analysis and calculations were conducted using the “R” software version 4.2.1, utilizing the “lavaan” library version 0.6–12 ( Rosseel, 2012 )." 3765 4525 W4393273489.pdf 3 34 separator 0.997071 ¶ 4525 4527 W4393273489.pdf 3 35 title 0.9885106 2.5 Ethical considerations 4527 4554 W4393273489.pdf 3 36 separator 0.99424964 ¶ 4554 4556 W4393273489.pdf 3 37 text 0.99943537 "The research was approved by the Ethics Committee of the Peruvian Union University (Reference: 2023-CEUPeU-0016)." 4556 4673 W4393273489.pdf 3 38 separator 0.9957452 ¶ 4673 4675 W4393273489.pdf 3 39 title 0.9820831 3 Results 4675 4685 W4393273489.pdf 3 40 separator 0.9890215 ¶ 4685 4687 W4393273489.pdf 3 41 title 0.9910081 3.1 Preliminary analysis 4687 4712 W4393273489.pdf 3 42 separator 0.99576217 ¶ 4712 4714 W4393273489.pdf 3 43 text 0.99954873 "The scores of the study variables were scaled to values between 0 and 30 to facilitate their visualization, with the understanding that this procedure does not affect the correlation values between the variables." 4714 4933 W4393273489.pdf 3 44 separator 0.7680253 ¶ 4934 4936 W4393273489.pdf 3 45 text 0.9925975 "Table 1 presents the descriptive results, including skewness (A), and the correlation results that range between −0.33 and 0.77 for the study variables. Additionally, in this table, the internal consistency alpha" 4936 5156 W4393273489.pdf 3 46 separator 0.9510946 ¶ 5157 5159 W4393273489.pdf 3 47 caption 0.94320613 FIGURE 1 5159 5168 W4393273489.pdf 3 48 separator 0.810969 ¶ 5168 5170 W4393273489.pdf 3 49 caption 0.973406 Hypothesized model. 5170 5190 W4393273489.pdf 3 0 paratext 0.9813882 "Vol.:(0123456789)1 3Sustainability Science (2021) 16:709 https://doi.org/10.1007/s11625-020-00892-w" 0 102 W3113384738.pdf 0 1 separator 0.98467755 ¶ 102 104 W3113384738.pdf 0 2 title 0.97218496 CORRECTION 104 115 W3113384738.pdf 0 3 separator 0.96307504 ¶ 115 117 W3113384738.pdf 0 4 text 0.8114339 "Correction to: Framing natural assets for advancing sustainability research: translating different perspectives into actions" 117 245 W3113384738.pdf 0 5 separator 0.9919189 ¶ 245 247 W3113384738.pdf 0 6 contact 0.67028 Maria Jose Martinez‐Harms1,2 · Stefan Gelcich 247 294 W3113384738.pdf 0 7 table 0.55662954 1 · 294 297 W3113384738.pdf 0 8 contact 0.5384826 Rainer M 297 306 W3113384738.pdf 0 9 table 0.44952115 . 306 307 W3113384738.pdf 0 10 contact 0.5048739 Krug 307 312 W3113384738.pdf 0 11 table 0.5770439 3 · 312 315 W3113384738.pdf 0 12 contact 0.56299424 Fleur J 315 323 W3113384738.pdf 0 13 table 0.4532607 . 323 324 W3113384738.pdf 0 14 contact 0.547258 F 324 326 W3113384738.pdf 0 15 table 0.43831608 . 326 327 W3113384738.pdf 0 16 contact 0.48891363 Maseyk 327 334 W3113384738.pdf 0 17 table 0.5642082 2,4 · 334 339 W3113384738.pdf 0 18 contact 0.5387236 Hannah Moersberger 339 358 W3113384738.pdf 0 19 table 0.6204339 5 · ¶ 358 364 W3113384738.pdf 0 20 contact 0.4431834 Archi 364 370 W3113384738.pdf 0 21 table 0.53861594 Rastogi6 · Geo 370 385 W3113384738.pdf 0 22 contact 0.44918773 ffrey Wambug 385 397 W3113384738.pdf 0 23 table 0.55946887 u7 · Cornelia B. Krug8,12 · 397 424 W3113384738.pdf 0 24 contact 0.42697835 Eva 424 428 W3113384738.pdf 0 25 table 0.43088055 M. Sp 428 434 W3113384738.pdf 0 26 contact 0.44231611 ehn 434 437 W3113384738.pdf 0 27 table 0.59548265 9 · 437 440 W3113384738.pdf 0 28 contact 0.39197236 Unai 440 445 W3113384738.pdf 0 29 table 0.3860198 Pas 445 449 W3113384738.pdf 0 30 contact 0.40006533 cual 449 453 W3113384738.pdf 0 31 table 0.5252967 10,11,13 453 461 W3113384738.pdf 0 32 separator 0.9704301 ¶ 461 463 W3113384738.pdf 0 33 paratext 0.9453203 "Published online: 24 December 2020 © The Author(s) 2020 Correction to: Sustainability Science (2018) 13:1519–1531 https ://doi.org/10.1007/s1162 5-018-0599-5" 463 631 W3113384738.pdf 0 34 separator 0.99252814 ¶ 631 633 W3113384738.pdf 0 35 text 0.7517824 "In the original publication of the article, under the acknowl- edgments section, the project number was published incorrectly. The correct sentence should read as “MMH is supported by Fondo Nacional de Desarrollo Científico y Tecnológico FONDECYT 3180118”." 633 901 W3113384738.pdf 0 36 separator 0.98674273 ¶ 901 903 W3113384738.pdf 0 37 paratext 0.9047027 "Open Access This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/." 903 1790 W3113384738.pdf 0 38 separator 0.9754437 ¶ 1790 1792 W3113384738.pdf 0 39 title 0.664754 Publisher’s Note 1792 1809 W3113384738.pdf 0 40 text 0.6424618 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 1809 1931 W3113384738.pdf 0 41 separator 0.4634848 ¶ 1931 1933 W3113384738.pdf 0 42 paratext 0.7709979 "The original article can be found online at https ://doi.org/10.1007/ s1162 5-018-0599-5." 1933 2025 W3113384738.pdf 0 43 separator 0.9503436 ¶ 2025 2027 W3113384738.pdf 0 44 contact 0.995032 "* Maria Jose Martinez-Harms mariajosesmart@gmail.com" 2028 2085 W3113384738.pdf 0 45 separator 0.9796259 ¶ 2085 2087 W3113384738.pdf 0 46 contact 0.97929525 "1 Center for Applied Ecology and Sustainability (CAPES), Center for the Study of Multiple-Drivers On Marine Socio-Ecological Systems, Pontificia Universidad Catolica de Chile, Avd. Libertador Bernardo O’Higgins 340, Santiago, Chile" 2087 2331 W3113384738.pdf 0 47 separator 0.58142316 ¶ 2331 2333 W3113384738.pdf 0 48 contact 0.9820557 "2 Australian Research Council Centre of Excellence for Environmental Decisions, School of Biological Sciences, The University of Queensland, Saint Lucia, QLD 4072, Australia" 2333 2516 W3113384738.pdf 0 49 separator 0.5192988 ¶ 2516 2518 W3113384738.pdf 0 50 contact 0.9768338 "3 Department of Evolutionary Biology and Environmental Studies, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland 4 The Catalyst Group, PO Box 362, Palmerston North 4440, New Zealand 5 Future Earth Paris Hub, Centre National de La Recherche Scientifique (CNRS), 4 Place Jussieu, 75005 Paris, France 6 Universalia Management Group, 245 Victoria Avenue, Suite 200, Westmount, QC, Canada7 School of Natural Resources and Environmental Studies, Karatina University, PO Box, Karatina 1957-10101, Kenya" 2518 3061 W3113384738.pdf 0 51 separator 0.5694598 ¶ 3061 3063 W3113384738.pdf 0 52 contact 0.99012715 "8 URPP Global Change and Biodiversity, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland" 3063 3177 W3113384738.pdf 0 53 separator 0.5205686 3177 3178 W3113384738.pdf 0 54 contact 0.96733785 "¶ 9 Global Mountain Biodiversity Assessment, Institute of Plant Sciences, University of Bern, Altenbergrain 21, 3013 Bern, Switzerland" 3178 3318 W3113384738.pdf 0 55 separator 0.84288883 ¶ 3318 3320 W3113384738.pdf 0 56 contact 0.9753014 "10 Basque Centre for Climate Change, University of the Basque Country (UPV-EHU), Sede Building 1, 1st Floor, Scientific Campus, Leioa, 48940 Bilbao, Spain" 3320 3481 W3113384738.pdf 0 57 separator 0.55699146 ¶ 3481 3483 W3113384738.pdf 0 58 contact 0.9859748 "11 Ikerbasque, Basque Foundation for Science, María Díaz Haro, 3, 48013 Bilbao, Spain" 3483 3572 W3113384738.pdf 0 59 separator 0.7956636 ¶ 3572 3574 W3113384738.pdf 0 60 contact 0.9854246 "12 bioDISCOVERY, Department of 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5584 6694 W4393193455.pdf 27 0 paratext 0.99077153 Symmetry 2022 ,14, 960 7 of 15 0 30 W4229375907.pdf 6 1 separator 0.9919671 ¶ 30 32 W4229375907.pdf 6 2 title 0.99162954 Table 2. Sample Images Before and After Data Augmentation. 32 91 W4229375907.pdf 6 3 separator 0.99544525 ¶ 91 93 W4229375907.pdf 6 4 table 0.9918081 "S.No. CategoriesNumber of Images before AugmentationNumber of Images after Augmentation 1 Solid Waste Images 1000 3000 2 Clean Images 1000 3000" 93 245 W4229375907.pdf 6 5 separator 0.9929211 ¶ 245 247 W4229375907.pdf 6 6 title 0.99192107 4. Proposed Methodology 247 271 W4229375907.pdf 6 7 separator 0.9966547 ¶ 271 273 W4229375907.pdf 6 8 text 0.99901235 "Two CNN models for solid waste detection using an image dataset captured by the UAV were used. Table 3 shows the architecture description of the proposed models." 273 437 W4229375907.pdf 6 9 separator 0.9971796 ¶ 437 439 W4229375907.pdf 6 10 title 0.9879254 Table 3. CNN Model Architectures. 439 473 W4229375907.pdf 6 11 separator 0.99249864 ¶ 473 475 W4229375907.pdf 6 12 table 0.99040115 "ModelsConvolution LayersMaxpool LayerParameters (in Millions)Input Layer SizeOutput Layer Size CNN1 3 3 25 (224,224,3) (2,1) CNN2 5 5 16 (224,224,3) (2,1)" 475 644 W4229375907.pdf 6 13 separator 0.9838177 ¶ 644 646 W4229375907.pdf 6 14 text 0.99907905 "The CNN1 model has three convolution layers and max pool layers as shown in the block diagram. One dropout layer is used to avoid overfitting. The flattening layer is used to flatten the input. The dense layer is the regularly deeply connected and frequently used layer. There are two dense layers used in CNN1. Table 4 shows the layer-wise description of the CNN1 model. The 224*224*3 sized images were used as the input to the proposed CNN1. In the convolution layer, the size of the filter was 3*3 and the number of the filter was 16. The output of the first convolution layer was 224*224*16. The max pool layer was used to reduce the size of the image. In the max pool layer, the 2*2 sized filter was used. The maxpool layer converted the input image size 224*224*16 into 112*112*16. The 112*112*16 sized image passed through the 2nd convolution layer from the max pool layer." 646 1538 W4229375907.pdf 6 15 separator 0.91755444 ¶ 1538 1540 W4229375907.pdf 6 16 text 0.99952644 "The 2nd convolution layer had a 3*3 size filter and the number of the filter was 32. The output of the 2nd convolution layer was 112*112*32. The 2nd maxpool layer reduced the size of the image from 112*112*32 to 56*56*32. The output of the 2nd maxpool layer was then passed through the 3rd convolution layer. The 3rd convolution layer used 64 filters." 1540 1895 W4229375907.pdf 6 17 separator 0.7801111 ¶ 1895 1897 W4229375907.pdf 6 18 text 0.99942505 "Therefore, the output of the 3rd convolution layer was 56*56*64. The 3rd maxpool layer converted the output image size of the 3rd convolution layer into 28*28*64. The output of the 3rd maxpool layer was passed through the dropout and flatten layers. The dropout ratio of the dropout layer was 0.4. The dropout ratio of 0.4 describes that the 40% features out of total extracting features are neglected. The dense layer performed some operations on the input and returned the output." 1897 2389 W4229375907.pdf 6 19 separator 0.98106897 ¶ 2389 2391 W4229375907.pdf 6 20 text 0.9993126 "The block diagram of the proposed CNN2 model has five convolution layers and max pool layers. One dropout layer was used to avoid the overfitting problem. The flattening layer was used to flatten the input. The dense layer is the regularly deeply connected and frequently used layer. There were two dense layers used in CNN2." 2391 2719 W4229375907.pdf 6 21 separator 0.967685 ¶ 2719 2721 W4229375907.pdf 6 22 text 0.9674366 "Table 5 shows the layer-wise description of the CNN2 model. The image of 224*224*3 size was used as the input to the convolution layer with a filter size of 3*3." 2721 2885 W4229375907.pdf 6 23 separator 0.86718905 ¶ 2885 2887 W4229375907.pdf 6 24 text 0.9994233 "The number of the filter was 16. The output of the first convolution layer was 224*224*16 and was directly connected to the maxpool layer with a filter size of 2*2. The maxpool layer reduced the input image size from 224*224*16 to 112*112*16, which passed through the 2nd convolution layer with a filter size of 3*3. The number of the filter was 16. The output of the 2nd convolution layer was 112*112*16. The 2nd maxpool layer re- duced the image from 112*112*16 to 56*56*16. The output of the 2nd maxpool layer passed through the 3rd convolution layer having 32 filters. The output of the 3rd convolution layer was 56*56*32, which was converted into 28*28*32 by the 3rd maxpool layer. The CNN2 model had two more convolution layers and maxpool layers. Therefore, after applying the convolution and maxpool operation, the size of the 5th maxpool layer was 14*14*7, which was passed through the dropout layer and flattening layer. The dropout ratio of the" 2887 3856 W4229375907.pdf 6 0 title 0.8364664 N1PR : 1kb wild type promoter construct 0 39 W4361819327.pdf 0 1 separator 0.9924598 ¶ 39 41 W4361819327.pdf 0 2 text 0.81666327 N1PRmt: all G or C in p53 binding sites replaced with A or T N1PRmt2: all G or C in putative KLF5 binding sites #3 and #4 replaced with A or T 0.00.51.01.5 41 197 W4361819327.pdf 0 3 table 0.8847101 "2.0Empty vector KLF5 0.00.51.01.52.0 NS shRNA KLF5 shRNA N1PR N1PRmt N1PRmt2 pGL2 N1PR N1PRmt N1PRmt2 pGL2 Relative" 197 322 W4361819327.pdf 0 4 title 0.61366284 luciferase activity 322 342 W4361819327.pdf 0 5 table 0.9118984 "Relative luciferase activity EPC2-hTERT cells EPC2-hTERT cells BA 0 1 2 3" 342 422 W4361819327.pdf 0 6 title 0.77356 Relative mRNA levels 422 443 W4361819327.pdf 0 7 separator 0.65371966 ¶ 443 445 W4361819327.pdf 0 8 table 0.95928407 "EPC2-hTERT cellsControl +KLF5 Control KLF5 shRNA Relative mRNA levels 0 0.5 1.0 1.5 EPC2-hTERT cellsKLF5 NOTCH1 KLF5 NOTCH1" 445 600 W4361819327.pdf 0 0 text 0.99969906 "lower part). Intriguingly, we identi fied two lead compounds that broadly abrogate elaboration of glycans in the Golgi apparatus withoutaffecting protein secretion. The compound library was limited in sizeand future screening with larger compound libraries may lead to more selective inhibitors. However, the study clearly illustrates the potential of the cell-based array platform to evaluate and dissect effects ofinhibitors on glycosyltransferase isoenzymes and individual biosyn-thetic steps in different glycosylation pathways." 0 537 W4321369012.pdf 11 1 separator 0.9696069 ¶ 537 539 W4321369012.pdf 11 2 text 0.9996056 "The two compounds we did identify within the limited library, NSC80997 and NSC255112, however, turned out to have interestingproperties with wide applicability as reversible inhibitors of elaborateglycan features such as galactosylation and sialylation associated withdifferent types of glycoproteins and other glycoconjugates. Althoughstructurally different, we found that both compounds readily andreversibly abrogated elongation of GalNAc-type O-glycosylation, pro- cessing of complex type N-glycans after the key branching step, and the biosynthesis of GAG chains. The biosynthetic steps affected are allpredicted to occur in the Golgi, while glycosylation located in ER andearly Golgi was unaffected. Treatment of HEK cells with these com-pounds did not affect secretion and did not appear to induce sig-nificant changes in the overall proteome, but immunocytology (and metabolic labeling of sialylation) demonstrated that Golgi-residentproteins dispersed within 1-2 h without being lost (Fig. 5aa n dS u p - plementary Fig. 5A, B). These effects were reversible upon removal ofinhibitors, and the induction/recovery kinetics of the Golgi fragmen-tation and effects on reporter and surface glycosylation were highly similar, suggesting that the Golgi disruption directly led to the effects observed on protein glycosylation. Aberrant glycosylation is a com-mon feature found in cells with fragmented Golgi apparatus includingin cancer cells 76–79." 539 2007 W4321369012.pdf 11 3 separator 0.9780038 ¶ 2007 2009 W4321369012.pdf 11 4 text 0.99974144 "GalNAc-Ts are generally found throughout the Golgi stacks80and initiate O-glycosylation after the protein folding in ER. However, itshould be noted that relocation of GalNAc-Ts to ER has been reportedas a feature of cancer cells and cause of the characteristic expression oftruncated Tn O-glycans in cancer 81. We found that lower doses of the inhibitors abrogated O-glycan elongation but not the initiation leadingto accumulation of Tn O-glycans (Fig. 1e) could potentially suggest that the inhibitors partly redistributed GalNAc-Ts to ER although this was not apparent from the immunocytology results. However, given thatthe N-glycan branching step by the MGATs was not affected sub-stantially, it is more likely that the inhibitors have lower effects onglycosylation steps performed in the early cis-Golgi stacks." 2009 2836 W4321369012.pdf 11 5 separator 0.97822016 ¶ 2836 2838 W4321369012.pdf 11 6 text 0.99958634 "NSC80997 is a derivate of cortivazol, a synthetic steroid that acts as high-af finity ligand for the GR 82–84, and these share the four ring (A- D) steroid structure and a phenylpyrazol group at the A-ring (Fig. 3a)." 2838 3060 W4321369012.pdf 11 7 separator 0.8096359 ¶ 3060 3062 W4321369012.pdf 11 8 text 0.9957569 "This bulky group has been shown to induce structural changes in theGR ligand-binding pocket creating additional interactions betweencortivazol and the GR and enhancing the binding af finity 20 –50 times compared to dexamethasone 49,85,86. Because of this increased binding affinity, cortivazol was assessed in clinical trials for corticosteroid- mediated pain relief after intra-articular, periarticular, or epiduralinjection without clear outcome or clear adverse effects, andapparently the use and production was terminated in 2017 87,88." 3062 3611 W4321369012.pdf 11 9 separator 0.9801837 ¶ 3611 3613 W4321369012.pdf 11 10 text 0.999685 "NSC255112 is a derivate of the HSP90 inhibitor geldanamycin. HSP90and other proteins including HSP70 and FKBP4 interact with GR andretain GR in the cytoplasm 51,89. Binding of a ligand releases the GR from HSP90 and allows for traf fic to the nucleus and transcriptional regulation of in flammatory genes51,90. Binding of NSC80997 to the GR or inhibition of HSP90 by NSC255112 thus could potentially releasethe GR. We did observe shuttling of the GR to the nucleus after treatment with high and low concentrations of both compounds (Fig. 3B and Supplementary Fig. 3A), however, other GR steroid ligands tested did not show the same effects on glycosylation asNSC80997 and NSC255112. Moreover, KO of the GR gene did notabolish the effects of the inhibitor compounds, and treating cellspretreated with the high-af finity GR antagonist mifepristone also did not affect the inhibition (Fig. 3c, d). These results indicate that NSC80997 and NSC255112 affect Golgi glycosylation largely inde-pendent of the GR pathway." 3613 4641 W4321369012.pdf 11 11 separator 0.9629352 ¶ 4641 4643 W4321369012.pdf 11 12 text 0.9982629 "Notably, while the NSC255112 analog geldanamycin is cytotoxic, we noticed induction of Tn in cells treated with other known HSP90inhibitors (Supplementary Fig. 3D), and inhibition and depletion ofHSP90 have previously been linked to Golgi fragmentation 59,60.H S P 9 0 binds the microtubule-associated protein 4 (MAP4), which is essentialfor maintaining microtubule acetylation and stabilization. HSP90depletion leads to decreased levels of MAP4 and thus fragmentation ofthe Golgi system, but effects on glycosylation have not been reportedpreviously 60. However, we observed no reduction in the levels of acetylated tubulin upon treatmen t with NSC80997, suggesting that the microtubule network remains intact. A study has proposed that loss of HSP90 leads to Golgi fragmentation mediated by non-muscle myosin IIA (NMIIA)/core2 N-acetylglucosaminyltransferase-M (C2GnT-M, GCNT3) complex formation 59. Here, we were unable to establish viable HEK293 cells with KO of HSP90. Reduction of NSC80997 toNSC80997-KR decreased the Tn induction effect twofold (Fig. 3e, f)." 4643 5729 W4321369012.pdf 11 13 separator 0.93562114 ¶ 5729 5731 W4321369012.pdf 11 14 text 0.9994592 "Further dissection of these compounds is needed to more speci fically reveal the functional group(s) that mediate the Golgi fragmentationand abrogation of glycan elaboration." 5731 5907 W4321369012.pdf 11 15 separator 0.93552583 ¶ 5907 5909 W4321369012.pdf 11 16 text 0.99494326 "We ruled out that NSC80997 and NSC255112 act like BFA 91.F i r s to f all, these compounds do not impair protein secretion (SupplementaryFig. 6C). Secondly, because they induce fragmentation of the Golgi apparatus rather than the redistribution of Golgi into the ER induced by BFA (Fig. 5e, g and Supplementary Fig. 6) 92. Interestingly, this pro- cess involves the initial formation of short tubules that later fragmentinto smaller structures and disperse throughout the cytoplasm 62." 5909 6409 W4321369012.pdf 11 17 separator 0.67212486 ¶ 6409 6411 W4321369012.pdf 11 18 text 0.9951976 "Thirdly, the compounds do not affect the recruitment of the coatomercomponent β-COP, and this is a key step for the initiation of the BFA- dependent tubulation 93. The lack of effect on the microtubules rules out that the fragmentation is the result of the well-established effect ofmicrotubule-disrupting agents on the Golgi apparatus 94. Therefore, the effect of the NSC80997 and NSC255112 compounds on the Golgistructure is mediated by a completely different mechanism(s), which will require extensive efforts to be fully dissected." 6411 6959 W4321369012.pdf 11 19 separator 0.9862797 ¶ 6959 6961 W4321369012.pdf 11 20 text 0.9996377 "Thefinding that NSC80997 and NSC255112 rapidly and reversibly disrupts cellular glycosylation without substantially altering cell via-bility and capacity for secretion of recombinant glycoproteins makesthese compounds highly attractive for use to probe whether proteinsare glycosylated and explore functions of glycoproteins at the cellsurface. To illustrate this, we demonstrated applications related tocancer immunotherapy and viral infections. Thus, pulsing target cellswith the inhibitor compounds induced the truncated cancer-associated O-glycan Tn 29,63, which triggered ADCC activity by mAbs directed to Tn-glycopeptide epitopes in MUC1 and FXYD5 (Fig. 6c)." 6961 7631 W4321369012.pdf 11 21 separator 0.94531345 ¶ 7631 7633 W4321369012.pdf 11 22 text 0.99956304 "Such antibodies are promising for therapeutic interventions58,84and appropriate cell lines to study their ADCC activity are missing66.W e also demonstrated the use of the inhibitor compounds to explore theeffect of glycosylation on SARS-CoV-2 infection, validating theimportance of HS in the binding and infection (Fig. 7). The NSC80997 and NSC255112 compounds may become useful reagents to reversiblyinterfere with Golgi glycosylation for probing the contribution of ela-borated glycans in biological interactions." 7633 8155 W4321369012.pdf 11 23 separator 0.9797429 ¶ 8155 8157 W4321369012.pdf 11 24 text 0.9995966 "In summary, we developed an elaborate cell-based assay for screening of GalNAc-T isoenzymes inhibitors, and although our initialscreening of a small compound library did not identify speci fic inhi- bitors the assay was validated and can be used for further screening of larger compound libraries. We did identify two potent reversible inhibitors that selectively affect Golgi-located glycosylation withoutaffecting viability and secretion, and these compounds should bewidely applicable and simple tools to investigate the role ofglycosylation." 8157 8710 W4321369012.pdf 11 25 paratext 0.9853759 Article https://doi.org/10.1038/s41467-023-36598-7 8710 8760 W4321369012.pdf 11 26 separator 0.59223235 ¶ 8760 8762 W4321369012.pdf 11 27 paratext 0.9814469 Nature Communications | (2023) 14:948 12 8762 8812 W4321369012.pdf 11 0 separator 0.6010692 "¶ " 1 9 W2758438815.pdf 8 1 paratext 0.9587535 "¶ 18 ULTIMA TICS , Vol. IX, No. 1 | Juni 2017 ISSN 2085 -4552" 9 76 W2758438815.pdf 8 2 separator 0.9954443 ¶ 77 79 W2758438815.pdf 8 3 text 0.99335545 "tampilan tersebut yang memiliki akurasi terbesar adalah percobaan dengan menggunakan remove low information gain dan tanpa menggunakan preprocess ." 79 233 W2758438815.pdf 8 4 separator 0.73815495 ¶ 234 236 W2758438815.pdf 8 5 text 0.99519897 "Percobaan yang memiliki number of leaves dan size of tree terkecil adalah tanpa preprocess dan remove low information gain . Percobaan dengan waktu pembuatan tree tercepat adalah remove low information gain ." 236 455 W2758438815.pdf 8 6 separator 0.99423236 ¶ ¶ 456 462 W2758438815.pdf 8 7 title 0.94519526 Gambar 16 Bar Chart Kedua Hasil Uji Coba 462 504 W2758438815.pdf 8 8 separator 0.99395776 ¶ 505 507 W2758438815.pdf 8 9 text 0.99750483 "Gambar 16 menunjukkan tampilan bar chart dari hasil uji coba menggunakan dua kombinasi metode preproses yang telah dilakukan sebelumnya. Pada tampilan tersebut yang memiliki akurasi terbesar adalah percobaan dengan menggunakan kombinasi replace missing value dan discretize . Percobaan yang memiliki number of leaves dan size of tree terkecil adalah kombinasi remove low information gain , replace missing value , dan discretize . Percobaan dengan waktu pembuatan tree tercepat adalah kombinasi replace missing value dan discretize ." 507 1073 W2758438815.pdf 8 10 separator 0.9972713 ¶ 1075 1077 W2758438815.pdf 8 11 title 0.9887419 V. SIMPULAN 1077 1089 W2758438815.pdf 8 12 separator 0.9958304 ¶ 1091 1093 W2758438815.pdf 8 13 text 0.99921453 "Rancang bangun aplikasi pendeteksi penyakit ginjal kronis dengan menggunakan algoritma C4.5 telah berhasil dibuat, dengan bantuan dari weka library dalam pembuatan algoritma decision tree yang dihasilkan dapat melakukan prediksi terhadap penyakit ginjal kronis. Uji coba dilakukan untuk mengetahui seberapa besar tingkat akurasi yang dapat dihasilkan oleh aplikasi. Proses pengujian dilakukan dengan menggunakan cross-validation dan berdasarkan hasil yang sudah dihitung aplikasi ini memiliki akurasi 91.50% pada saat decision tree dibuat tanpa menggunakan preprocess menu. Perkembangan yang didapatkan dalam melakukan preproses adalah pengurangan waktu yang diperlukan untuk membuat decision tree . Akurasi yang didapatkan setelah preproses tidak ada yang memiliki peningkatan. Ukuran decision tree bertambah besar jika menggunakan preproses discretize dan replace missing value . Metode yang meningkatkan cepatnya pembuatan decision tree adalah remove low information gain , replace missing value , dan discretize . Metode yang paling baik digunakan berdasarkan percobaan yang dilakukan adalah remove low information gain , yang menghasilkan akurasi 91.50 % dengan ukuran tree dan waktu pembuatan tree yang minimum." 1093 2386 W2758438815.pdf 8 14 separator 0.99634635 ¶ 2388 2390 W2758438815.pdf 8 15 title 0.96624404 DAFTAR PUSTAKA 2390 2405 W2758438815.pdf 8 16 separator 0.9935421 ¶ 2407 2409 W2758438815.pdf 8 17 bibliography 0.98726743 "[1] Aswano. 2014. MAKALAH GAGAL GINJAL KRONIK. Tersedia dalam: http://www.slideshare.net/septianraha/makalah-gagal-ginjal- kronik-37197034 . Diakses 2 Maret 2016." 2409 2581 W2758438815.pdf 8 18 separator 0.9673862 ¶ 2583 2585 W2758438815.pdf 8 19 bibliography 0.99310035 "[2] Kidney Disease Statistics for the United States. 2016. National Institute of Diabetes and Digestive and Kidney Diseases. [Online]. Avalaible: https://www.niddk.nih.gov/health- information/health-statistics/kidney-disease" 2585 2818 W2758438815.pdf 8 20 separator 0.96941143 ¶ 2819 2821 W2758438815.pdf 8 21 bibliography 0.99741894 "[3] Rohman, A. 2013. Penerapan Algoritma C4.5 Berbasis Adaboost untuk Prediksi Penyakit Jantung . Majalah Ilmiah Universitas Pandanaran Vol 11. No. 26." 2821 2979 W2758438815.pdf 8 22 separator 0.93771905 ¶ 2980 2982 W2758438815.pdf 8 23 bibliography 0.9978051 "[4] Puteri, N. A., Maharani, W., Suliiyo, M. D. 2013. Prediksi Penyakit Jantung dengan Algoritma Classification and Regression Tree . Telkom University" 2982 3140 W2758438815.pdf 8 24 separator 0.5865575 ¶ 3141 3143 W2758438815.pdf 8 25 bibliography 0.988076 "[5] Gorunescu, F. 2011. Data Mining: Concepts, Models and Techniques. [6] Kusrini. 2007. Konsep dan Aplikasi Sistem Pendukung Keputusan. Yogyakarta: Penerbit Andi." 3143 3317 W2758438815.pdf 8 26 separator 0.90352285 ¶ 3318 3320 W2758438815.pdf 8 27 bibliography 0.9970422 "[7] Sangadah, N. dan Tri, S. P. R. 2012. MAKALAH GAGAL GINJAL AKUT DAN KRONIS . Tersedia dalam: http://www.scribd.com/doc/93094328/MAKALAH-GAGAL- GINJAL-KRONIS#scribd . Diakses 2 Maret 2016." 3320 3519 W2758438815.pdf 8 28 separator 0.95036256 ¶ 3521 3523 W2758438815.pdf 8 29 bibliography 0.99675256 "[8] Aisyah, J. 2011. Karakteristik Penderita Gagal Ginjal Rawat Inap Di RS Haji Medan Tahun 2009 Tersedia dalam: http://repository.usu.ac.id/handle/123456789/24681 . Diakses 2 Maret 2016." 3523 3720 W2758438815.pdf 8 30 separator 0.9646051 ¶ 3721 3723 W2758438815.pdf 8 31 bibliography 0.99761444 "[9] Ridwan, M., Suryono, H., Sarosa, M. 2013. Penerapan Data Mining Untuk Evaluasi Kinerja Akademik Mahasiswa Menggunakan Algoritma Naïve Bayes Classifier." 3723 3885 W2758438815.pdf 8 32 separator 0.62312424 ¶ 3886 3888 W2758438815.pdf 8 33 bibliography 0.988659 "[10] Han J., Kamber M., Pei J. 2012. Data Mining: Concepts and Techniques 3rd Edition. [11] Mark Hall, Eibe Frank, Geoffrey Holmes, Bernhard Pfahringer, Peter Reutemann, Ian H. Witten (2009); The WEKA Data Mining Software: An Update; SIGKDD Explorations, Volume 11, Issue 1 ." 3888 4180 W2758438815.pdf 8 34 separator 0.82218516 ¶ 4181 4183 W2758438815.pdf 8 35 bibliography 0.99711984 "[12] Dr. Bhargava, N., Dr. Bhargava, R., Mathuria, M. 2013 . International Journal of Advanced Research in Computer Science and Software Engineering. ." 4183 4343 W2758438815.pdf 8 36 separator 0.5292059 ¶ 4344 4346 W2758438815.pdf 8 37 bibliography 0.9886123 "[13] Sayad, S. 2010. Decision Trees: Classification & Regression . University of Toronto. [14] Lichman, M. 2013. {UCI} Machine Learning Repository . [Online]. Available : http://archive.ics.uci.edu/ml" 4346 4558 W2758438815.pdf 8 38 separator 0.8577746 ¶ ¶ 4558 4564 W2758438815.pdf 8 39 table 0.9854702 "90,25 90,5 91,5 90,5 11 14 13917 20 1814 4,67 3,11 2,78 3,14 0102030405060708090100 Remove Low Information Gain + Replace Missing ValueRemove Low Information Gain + DiscretizeReplace Missing Value + DiscretizeRemove Low Information Gain + Replace Missing Value + Discretize Accuracy Number of Leaves Size of Tree Time to Make Tree" 4564 4927 W2758438815.pdf 8 40 separator 0.96467006 ¶ 4927 4929 W2758438815.pdf 8 0 paratext 0.82299834 "Review of: ""Antino" 0 18 W4213263354.pdf 0 1 title 0.5358946 ciceptive 18 27 W4213263354.pdf 0 2 paratext 0.52800536 activities 27 38 W4213263354.pdf 0 3 title 0.5033309 of 38 41 W4213263354.pdf 0 4 paratext 0.5838245 "a novel diarylpentano" 41 65 W4213263354.pdf 0 5 title 0.5019268 id 65 67 W4213263354.pdf 0 6 paratext 0.5366018 an 67 70 W4213263354.pdf 0 7 title 0.5049976 alogue 70 76 W4213263354.pdf 0 8 paratext 0.72595376 ", 2-benzoyl-6-(3-bromo-4- hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice""" 76 188 W4213263354.pdf 0 9 separator 0.83598626 ¶ 188 190 W4213263354.pdf 0 10 paratext 0.9173718 Raquel Soares Santos 190 211 W4213263354.pdf 0 11 separator 0.98984635 ¶ 211 213 W4213263354.pdf 0 12 title 0.9893634 Potential competing interests: 213 244 W4213263354.pdf 0 13 separator 0.990329 ¶ 244 246 W4213263354.pdf 0 14 text 0.99125475 "The author(s) declared that no potential competing interests exist. This is a study that aims to investigate the antinociceptive effect of a new compound on acute inflammatory pain and thermal stimuli in murine models. BBHC, a compound synthesized by the research group itself, when injected intraperitoneally, generates an important antinociceptive effect, compared to reference analgesic drugs, such as morphine and acetylsalicylic acid. BBHC was also effective against peripheral nociception with involvement of TRPV1 receptors, in addition to participating in the glutamatergic pain pathway. ¶" 247 857 W4213263354.pdf 0 15 separator 0.5248354 859 860 W4213263354.pdf 0 16 text 0.9836395 "¶ Below are considerations about the work, which seems to have been very well conducted and which may be another step towards the discovery of a new potentially effective analgesic drug." 860 1048 W4213263354.pdf 0 17 separator 0.9928348 ¶ ¶ 1048 1054 W4213263354.pdf 0 18 title 0.9920652 INTRODUCTION 1054 1067 W4213263354.pdf 0 19 separator 0.9934002 ¶ 1067 1069 W4213263354.pdf 0 20 text 0.99400383 "1. Justification is relevant. Apparently, the group seems to be up to date on the process of creating a new compound and potential analgesic drug, in addition to constantly updating on the work generated in the laboratory. 2. In the introduction, I suggest clarifying the objective of the work, regarding the route of administration of the compound. It is important to situate the reader as to how the work is carried out: is it peripheral or central? Does it have an effect on local pain? Does it have effect in local injection, without systemic effect? As it is a new drug, it may be interesting to assess this point." 1069 1701 W4213263354.pdf 0 21 separator 0.9927823 ¶ ¶ 1701 1707 W4213263354.pdf 0 22 title 0.9916067 MATERIALS AND METHODS 1707 1729 W4213263354.pdf 0 23 separator 0.9943126 ¶ 1729 1731 W4213263354.pdf 0 24 text 0.9969295 "1. The article makes it very clear how the synthesis of the drug was carried out, preparation of solutions, aspects related to the use of animals in research (authorization of the ethics committee for the use of animals in research, environmentalization of animals, allocation, number of animals per group) and the standardization of the technique. 2. Choice of study method is pertinent. 3. Again, I suggest performing an experiment relating the new compound to local action (eg using the formalin test itself or carrageenan or prostaglandin injection). In humans, the use of drugs is usually carried" 1731 2345 W4213263354.pdf 0 25 separator 0.9657176 ¶ 2345 2347 W4213263354.pdf 0 26 paratext 0.9725214 "Qeios, CC-BY 4.0 · Review, February 13, 2022 Qeios ID: UBG04Y · https://doi.org/10.32388/UBG04Y" 2347 2456 W4213263354.pdf 0 27 separator 0.6202016 ¶ 2456 2458 W4213263354.pdf 0 28 paratext 0.9378456 "1 / 2" 2458 2468 W4213263354.pdf 0 0 title 0.97742224 "MENTAL HEALTH OF HOLOCAUST SURVIVORS AND OTHER OLDER ADULTS DURING THE COVID-19 PANDEMIC IN ISRAEL" 0 104 W4200369413.pdf 0 1 separator 0.9901321 ¶ 104 106 W4200369413.pdf 0 2 contact 0.9387939 "Ella Cohn-Schwartz, Yaacov Bachner , and Sara Carmel, Ben-Gurion University, Beer-Sheva, HaDarom, Israel" 106 217 W4200369413.pdf 0 3 separator 0.9851903 ¶ 217 219 W4200369413.pdf 0 4 text 0.9995902 "Holocaust survivors could be especially vulnerable to the negative effects of the COVID-19 pandemic due to their early life traumas. Thus, the current study examines the ef - fects of the pandemic on the mental health of Holocaust survivors in Israel, compared to adults who did not experi - ence the Holocaust. We collected quantitative data from 305 adults aged 75+ (38% Holocaust survivors) in Israel during the COVID-19 pandemic. The results indicate that Holocaust survivors were worried to a greater extent from COVID-19 and reported greater depression which became worse during the pandemic. On the other hand, despite these differences, the two groups were similar in their will to live. In conclu - sion, Holocaust survivors seem to be more vulnerable to the COVID-19 pandemic, strengthening the vulnerability hypoth - esis, while also showing resilience in their will to live. Policy makers and practitioners should pay special attention to this particularly vulnerable population during these difficult times." 219 1284 W4200369413.pdf 0 5 separator 0.99646443 ¶ 1284 1286 W4200369413.pdf 0 6 title 0.9911545 "DISASTER VULNERABILITY IN LONG-TERM CARE: THE IMPORTANCE OF SOCIAL AND ORGANIZATIONAL CONNECTIONS" 1286 1390 W4200369413.pdf 0 7 separator 0.994717 ¶ 1390 1392 W4200369413.pdf 0 8 contact 0.9351611 "Lindsay Peterson,1 Debra Dobbs,2 Joseph June,3 David Dosa,4 and Kathryn Hyer,5 1. University of South Florida, Bradenton, Florida, United States, 2. University of South Florida, School of Aging Studies, University of South Florida, Florida, United States, 3. University of South Florida, Tampa, Florida, United States, 4. Brown University, Providence, Rhode Island, United States, 5. University of South Florida, University of South Florida, Florida, United States" 1392 1882 W4200369413.pdf 0 9 separator 0.9944995 ¶ 1882 1884 W4200369413.pdf 0 10 text 0.99954545 "The risks to older adults in nursing homes (NHs) and assisted living communities (ALCs) exposed to disasters are evident in prior research. However, little research has been conducted to understand the factors related to facilities’ vulnerability. This re - search examined NH and ALC experiences during Hurricane Irma in 2017. Qualitative interviews were conducted with rep - resentatives of facilities (N=100), transcripts were analyzed using Atlas.ti version 8. Team members met to reach consensus on codes and major themes and subthemes, which they analyzed using a conceptual model designed to identify factors related to the dis - aster vulnerability in long-term care (LTC). We found physical factors (e.g. location, physical characteristics) are important, but physical strength is not enough. Multiple social/organizational factors are critical. Results indicate managing a major disaster and protecting LTC residents involve social and organizational con - nections across a range of groups from staff and family members to emergency mangers and neighborhood associations." 1884 3011 W4200369413.pdf 0 11 separator 0.9828065 ¶ 3011 3013 W4200369413.pdf 0 12 paratext 0.8940065 Session 2265 (Paper) 3013 3034 W4200369413.pdf 0 13 separator 0.8583712 ¶ 3034 3036 W4200369413.pdf 0 14 title 0.99161565 Mobility, Disability, and Social Contexts 3036 3078 W4200369413.pdf 0 15 separator 0.6490426 3078 3079 W4200369413.pdf 0 16 title 0.9781899 "¶ FORMAL AND INFORMAL CARE USE OVER THE COURSE OF COGNITIVE DETERIORATION AMONG ADULTS WITH A DISABILITY" 3079 3189 W4200369413.pdf 0 17 separator 0.9929974 ¶ 3189 3191 W4200369413.pdf 0 18 bibliography 0.8303578 "HwaJung Choi,1 Kenneth Langa,1 Edward Norton,1 Tsai-Chin Choi,1 and Cathleen Connell,2 1." 3191 3284 W4200369413.pdf 0 19 contact 0.67909706 "University of Michigan, Ann Arbor, Michigan, United States, 2. University of Michigan School of Public Health, Ann Arbor, Michigan, United States" 3284 3437 W4200369413.pdf 0 20 separator 0.99313056 ¶ 3437 3439 W4200369413.pdf 0 21 text 0.9940004 "The dynamics between formal and informal care among persons with a disability may substantially differ over the course of their cognitive decline. Based on a nationally representative study of older adults, the analysis sample included 3,685 individuals who had at least one activity of daily living (ADL) limitation. We esti - mated probabilities of using formal care and informal care in the years before and over the course of dementia after controlling for sociodemographic factors, survey mode, and proxy interview status." 3439 3992 W4200369413.pdf 0 22 separator 0.91431206 ¶ 3992 3994 W4200369413.pdf 0 23 text 0.99642557 "The adjusted probability of receiving care from an in - formal helper increased before the onset of dementia: 36% in 4 years prior to the onset (T=-4); 46% at T=-2. In con - trast, the increase in the probability of using formal care was pronounced primarily at the onset of dementia; for example, the probability of overnight nursing home stay was 12% at T=-2 vs. 31% at T=0, which continued to increase over the subsequent years (39% at T=6). The probability of using nursing home care at the onset was significantly greater for women vs. men (Adjusted risk ratio (ARR)=1.21; p=0.010); non-Hispanic white vs. Hispanic (ARR=1.62; p=0.004); those with low vs. high wealth (ARR=1.60; p < 0.001); those without a spouse vs. with a spouse prior to the onset (ARR=1.39; p < 0.001); and those with all adult children living far vs. at least one coresident adult child prior to the onset (ARR=1.51; p= < 0.001)." 3994 4943 W4200369413.pdf 0 24 separator 0.92184186 ¶ 4944 4946 W4200369413.pdf 0 25 text 0.9974127 "Public policies and interventions aimed at providing for the needs of people with dementia should consider disparities in care use across racial/ethnic and socioeconomic groups." 4946 5130 W4200369413.pdf 0 26 separator 0.9955325 ¶ 5130 5132 W4200369413.pdf 0 27 title 0.98974305 "GENDER DIFFERENCES IN AVOIDING LATER-LIFE DISABILITY: A LIFE COURSE PERSPECTIVE" 5132 5215 W4200369413.pdf 0 28 separator 0.9892207 ¶ 5215 5217 W4200369413.pdf 0 29 contact 0.96946836 "Patricia Morton, Wayne State University, Detroit, Michigan, United States" 5217 5294 W4200369413.pdf 0 30 separator 0.9916434 ¶ 5294 5296 W4200369413.pdf 0 31 text 0.99959135 "Identifying the early origins of adult health has under - scored how experiences in the earliest stages of life can have lasting consequences. Whereas most research on the early origins of adult health has linked childhood conditions to worse health in adulthood, this study considered whether childhood conditions are associated with healthy aging." 5296 5660 W4200369413.pdf 0 32 separator 0.82717544 ¶ 5661 5663 W4200369413.pdf 0 33 text 0.9995042 "Guided by the World Health Organization’s emphasis on functional ability as a core component of healthy aging, the present study investigated the association between child - hood social conditions and avoiding later-life limitations in basic and instrumental activities of daily living, referred to as disability-free status. This study also tested potential health-related and socioeconomic mediators and examined whether these life course antecedents of healthy aging vary by gender. Analyzing a sample of 9,376 adults over age 50 from the Health and Retirement Study over 10 years (2006- 2016) revealed that childhood socioeconomic disadvan - tage reduced the odds of avoiding disability over time. For women, adult health lifestyles mediated this relationship whereas adult socioeconomic status (SES) mediated this re - lationship for men. Conditional indirect effects indicated that the mediational effects of body mass and education dif - fered between men and women (i.e., moderated mediation)." 5663 6708 W4200369413.pdf 0 34 separator 0.7426741 ¶ 6709 6711 W4200369413.pdf 0 35 text 0.86597574 The direct effects of childhood and adult SES also varied by 6711 6772 W4200369413.pdf 0 36 paratext 0.97206426 Innovation in Aging , 2021, Vol. 5, No. S1 201Downloaded from https://academic.oup.com/innovateage/article/5/Supplement_1/201/6465302 by guest on 18 May 2024 6772 6931 W4200369413.pdf 0 37 separator 0.99651515 ¶ 6931 6933 W4200369413.pdf 0 0 paratext 0.9395067 "100 ¶ ¶ Open Access: http://ejournal.poltekkesjakarta1.ac.id/index.php/adm Email: jurnalquality@poltekkesjakarta1.ac.id" 0 140 W4388923371.pdf 4 1 separator 0.9965769 ¶ 142 144 W4388923371.pdf 4 2 title 0.8827601 "Tabel 2 . Distribusi responden berdasarkan konseling dan kepatuhan minum obat pasien hipertensi di Puskesmas, Maret 2023 (n=70)" 144 278 W4388923371.pdf 4 3 separator 0.992404 ¶ 280 282 W4388923371.pdf 4 4 text 0.99016345 "Tabel 2 menunjukan yang melakukan konseling lebih banyak daripada yang tidak melakukan konseling sebanyak 41 (58,6%). Tingkat kepatuhan minum obat pada pasien hipertensi di puskesmas menunjukkan kepatuhan yang tinggi sebanyak 30 (42,9%) ." 283 539 W4388923371.pdf 4 5 separator 0.99588645 ¶ 540 542 W4388923371.pdf 4 6 title 0.74266756 "Tabel 3 . Perbandingan status pekerjaan dalam mengikuti konseling terhadap tingkat kepatuhan " 542 641 W4388923371.pdf 4 7 table 0.5453618 ¶ 641 642 W4388923371.pdf 4 8 title 0.5851465 minum obat pada pasien 642 666 W4388923371.pdf 4 9 table 0.4265945 hipertensi 666 676 W4388923371.pdf 4 10 title 0.540832 di Puskesmas 676 689 W4388923371.pdf 4 11 table 0.64351785 ", Maret 2023 (n=70)" 689 711 W4388923371.pdf 4 12 separator 0.9872504 ¶ ¶ 713 719 W4388923371.pdf 4 13 text 0.99572766 "Tabel 3 menunjukkan status pekerjaan (bekerja dan tidak bekerja) dalam mengikuti konseling memiliki hubungan yang signifikan ( p- value <0,05) terhadap tingkat kepatuhan. Terdapat perbandingan antara status pekerjaan (bekerja dan tidak bekerja) dalam mengikuti konseling terhadap kepatuhan minum obat yang dilihat dari akumulasi jumlah responden. Responden bekerja lebih banyak tidak melakukan konseling sehinggan kepatuhan minum obatnya rendah (57,9%)." 719 1201 W4388923371.pdf 4 14 separator 0.86768514 "¶ ¶ ¶" 1203 1221 W4388923371.pdf 4 15 title 0.696465 "Tabel 4 . Hubungan pasien yang bekerja dalam mengikuti konseling dengan tingkat kepatuhan " 1222 1317 W4388923371.pdf 4 16 table 0.5598175 ¶ 1317 1318 W4388923371.pdf 4 17 title 0.50672966 minum obat berdasarkan faktor confounding ( 1318 1363 W4388923371.pdf 4 18 table 0.5571741 usia, ¶ 1363 1371 W4388923371.pdf 4 19 title 0.45280933 1371 1372 W4388923371.pdf 4 20 table 0.4786871 jenis kelamin, dan lama menderita), Maret 2023 1372 1420 W4388923371.pdf 4 21 separator 0.40456814 ¶ 1420 1421 W4388923371.pdf 4 22 table 0.52997845 (n=70 ) 1421 1429 W4388923371.pdf 4 23 separator 0.9800072 ¶ ¶ 1430 1436 W4388923371.pdf 4 24 text 0.9956789 "Tabel 4 ditemukan hasil bahwa beberapa faktor confounding dengan konseling dan tingkat kepatuhan memiliki hubungan yang signifikan ( p- value <0,05). Usia pralansia yang bekerja dan tidak mengikuti konseling memiliki kepatuhan yang rendah (60,0%) dan menunjukkan hasil yang signifikan ( p-value =0,011), tingkat pendidikan SMA pada responden yang bekerja memiliki hubungan yang signifikan ( p-value =0,01) dengan konseling dan tingkat kepatuhan minum obat ." 1436 1922 W4388923371.pdf 4 25 separator 0.6106739 "¶ " 1923 1932 W4388923371.pdf 4 26 table 0.38555944 "¶ ¶ ¶" 1932 1949 W4388923371.pdf 4 27 separator 0.47522914 1951 1952 W4388923371.pdf 4 28 table 0.37379208 ¶ 1952 1953 W4388923371.pdf 4 29 separator 0.8215513 "¶ ¶" 1955 1965 W4388923371.pdf 4 30 table 0.99497104 "Frekuensi Presentase (%) Konseling Konseling 41 58,6 Tidak Konseling 29 41,4 Total 70 100 Tingkat Kepatuhan Rendah 21 30,0 Sedang 19 27,1 Tinggi 30 42,9 Total 70 100" 1966 2174 W4388923371.pdf 4 0 paratext 0.9865766 871 European Journal of Forest Research (2023) 142:865–882 0 58 W4362595082.pdf 6 1 separator 0.59422 ¶ 59 61 W4362595082.pdf 6 2 paratext 0.9832407 1 3 61 65 W4362595082.pdf 6 3 separator 0.9557281 ¶ 65 67 W4362595082.pdf 6 4 text 0.99228936 "were tested using a generalized linear model (GLM) with Poisson error distribution for count data and visualized with boxplots. Significantly different means between groups (for - est types) were separated using Tukey's post hoc test." 67 310 W4362595082.pdf 6 5 separator 0.97804374 ¶ 310 312 W4362595082.pdf 6 6 text 0.99651295 "For functional characterization of bryophyte assem- blages, we first calculated community means for each of the 13 traits (Table 2) using the funtcomp function in the FD package (Laliberté et al. 2015). The mean values of traits and trait states (27 in total), which represent the functional composition of assemblages, were then used as the input data for principal component analysis (PCA) to explore the distribution of plots and plot groups in the ordination space using the PCA function with automatic data standardization in the FactoMineR package (Hus- son et al. 2020). Visualizations were performed with the factoextra R package (Kassambara and Mundt 2020) to plot the 95% confidence intervals of group scores on the two-dimensional PCA ordination diagram." 312 1114 W4362595082.pdf 6 7 title 0.6793559 Differences Table 2 List of 1114 1143 W4362595082.pdf 6 8 caption 0.32433826 selected 1143 1152 W4362595082.pdf 6 9 title 0.39058608 traits (eight autecological, 1152 1181 W4362595082.pdf 6 10 table 0.38160345 three 1181 1187 W4362595082.pdf 6 11 title 0.36016527 1187 1188 W4362595082.pdf 6 12 table 0.35892916 morphological 1188 1201 W4362595082.pdf 6 13 title 0.29994497 and 1201 1205 W4362595082.pdf 6 14 table 0.35647652 two regeneration traits 1205 1229 W4362595082.pdf 6 15 bibliography 0.41558495 ). For details on the attributes of 1229 1264 W4362595082.pdf 6 16 table 0.2793901 categorical 1264 1276 W4362595082.pdf 6 17 bibliography 0.38265532 ¶ 1277 1279 W4362595082.pdf 6 18 table 0.3624119 1279 1280 W4362595082.pdf 6 19 bibliography 0.42675096 traits, see Bernhardt-Römermann et al. (2018) and Simmel et al. 1280 1343 W4362595082.pdf 6 20 table 0.3448524 ( 1343 1345 W4362595082.pdf 6 21 bibliography 0.3898525 2021 1345 1349 W4362595082.pdf 6 22 text 0.29462948 ) 1349 1350 W4362595082.pdf 6 23 separator 0.9966399 ¶ 1350 1352 W4362595082.pdf 6 24 title 0.949226 Functional trait Variable type Description 1352 1395 W4362595082.pdf 6 25 separator 0.98684025 ¶ 1395 1397 W4362595082.pdf 6 26 title 0.87613356 Autecological traits 1397 1418 W4362595082.pdf 6 27 separator 0.9413854 ¶ 1418 1420 W4362595082.pdf 6 28 text 0.9918646 "Indicator value for light (L) Ordinal Occurrence in relation to the relative irradiance intensity in the period when decidu- ous plants are in full leaf; Scale (1 to 9): 1—Plant in deep shade, 5—Semi-shaded plant, rarely in full light, 9—Plant in full light, mostly found in full sun, Ind— Indifferent" 1420 1729 W4362595082.pdf 6 29 separator 0.9506174 ¶ 1729 1731 W4362595082.pdf 6 30 text 0.98080313 "Indicator value for temperature (T) Ordinal Occurrence in temperature gradients from the Arctic and the Mediterranean and from alpine levels to the lowlands; Scale (1 to 9): 1—Cold indicator plant, found only in high mountains, mostly in alpine and nival levels, 5—Indicator of fairly warm conditions, from lowland to montane sites, but especially in submontane– temperate sites, 9—Indicator of extremely warm conditions, Ind—Indifferent" 1731 2180 W4362595082.pdf 6 31 separator 0.88612694 ¶ 2180 2182 W4362595082.pdf 6 32 text 0.7077597 2182 2183 W4362595082.pdf 6 33 title 0.69331855 Indicator value for continentality 2183 2217 W4362595082.pdf 6 34 text 0.9873196 "(K) Ordinal Occurrence in the gradient from the Atlantic coast to the interior of Eurasia, espe- cially with regard to temperature ranges; Scale (1 to 9): 1—Extreme oceanic, in Central Europe only in a few outposts, 5—Intermediate, weakly suboceanic to weakly subcontinental, 9—Extreme continental, virtually absent from Western Europe, Ind—Indifferent" 2217 2581 W4362595082.pdf 6 35 separator 0.9710891 ¶ 2581 2583 W4362595082.pdf 6 36 text 0.5495528 2583 2584 W4362595082.pdf 6 37 title 0.75456125 Indicator value for moisture 2584 2612 W4362595082.pdf 6 38 text 0.98928475 "(F) Ordinal Occurrence in the gradient from dry, rocky slopes with shallow soil to swampy ground; Scale (1 to 9): 1—Indicator of extreme dryness, restricted to soils that often dry out for some time, 5—Indicator of dampness, mainly on constantly moist or damp, but not wet soils, 9—Indicator of wet sites, often on water-satu- rated, poorly aerated soils, Ind—Indifferent" 2612 2995 W4362595082.pdf 6 39 separator 0.96916807 ¶ 2995 2997 W4362595082.pdf 6 40 title 0.7877647 Indicator value for soil reaction (R 2997 3034 W4362595082.pdf 6 41 text 0.9935036 ") Ordinal Occurrence in the gradient of soil acidity and lime content; Scale (1 to 9): 1—Indi- cator of extreme acidity, never found on weakly acidic or basic soils, 5—Indicator of moderately acid soils, only occasionally found on very acidic or on neutral to basic soils, 9—Indicator of basic reaction, always found on calcareous or other high-pH soils, Ind—Indifferent" 3034 3415 W4362595082.pdf 6 42 separator 0.9805699 ¶ 3415 3417 W4362595082.pdf 6 43 title 0.87938356 Indicator value for nutrient availability ( 3417 3461 W4362595082.pdf 6 44 text 0.95119226 "N) Ordinal Occurrence in the gradient of nutrient availability, eutrophication; Scale (1 to 9): 1—Plants on sites with very low nutrient content, 5—Plants on sites with medium nutrient content, 9—No bryophytes present (outcompeted by vascular plants)" 3461 3717 W4362595082.pdf 6 45 separator 0.99530745 ¶ 3717 3719 W4362595082.pdf 6 46 title 0.9683487 Affinity to forest habitat 3719 3746 W4362595082.pdf 6 47 text 0.9957943 "Categorical Information on how strongly species are bound to forest habitats; 4 trait attributes (M1.1—Largely restricted to closed forest, M1.2—Prefers forest edges and in clearings, M2.1—Occurs in forests as well as in open land, M2.2—May occur in forests, but prefers open land)" 3746 4037 W4362595082.pdf 6 48 separator 0.5323036 ¶ 4037 4039 W4362595082.pdf 6 49 text 0.97459257 "Hemeroby Ordinal Occurrence in the gradient of background human impact on the ecosystem, ranging from absent (1) to very strong (9)" 4039 4174 W4362595082.pdf 6 50 separator 0.994935 ¶ 4174 4176 W4362595082.pdf 6 51 title 0.98052806 Morphological traits 4176 4197 W4362595082.pdf 6 52 separator 0.98673326 ¶ 4197 4199 W4362595082.pdf 6 53 text 0.9833343 "Life form Categorical Life forms based on Mägdefrau (1968); five trait attributes (cushion, dendroid, mat, turf, weft)" 4199 4321 W4362595082.pdf 6 54 separator 0.9480173 ¶ 4321 4323 W4362595082.pdf 6 55 text 0.49965763 Life 4323 4328 W4362595082.pdf 6 56 title 0.5429475 strategy 4328 4337 W4362595082.pdf 6 57 text 0.9969289 "Categorical Life strategies according to During (1979); four trait attributes (colonists, perennial shuttle, perennial stayers, short-lived shuttle)" 4337 4489 W4362595082.pdf 6 58 separator 0.9873686 ¶ 4489 4491 W4362595082.pdf 6 59 table 0.93816364 Shoot length Numerical Mean shoot length expressed in cm 4491 4548 W4362595082.pdf 6 60 separator 0.69805217 ¶ 4548 4550 W4362595082.pdf 6 61 table 0.7109709 Re 4550 4553 W4362595082.pdf 6 62 title 0.48183984 generation 4553 4563 W4362595082.pdf 6 63 table 0.90240985 "traits Size of spores Numerical Mean size of spores expressed in μm" 4563 4633 W4362595082.pdf 6 64 separator 0.97991335 ¶ 4633 4635 W4362595082.pdf 6 65 title 0.8351465 Fruiting frequency 4635 4654 W4362595082.pdf 6 66 text 0.97228014 "Categorical Frequency of fruiting; five trait attributes (common, frequent, occasional, rare, very rare)" 4654 4762 W4362595082.pdf 6 0 paratext 0.99018997 Polymers 2024 ,16, 755 3 of 15 0 30 W4392657973.pdf 2 1 separator 0.9937786 ¶ 30 32 W4392657973.pdf 2 2 text 0.9940356 "IR spectra were recorded using a Shimadzu IRSpirit (Kyoto, Japan) at 4700 to 350 cm−1 (10 mg of sample without any specified sample preparation)." 32 180 W4392657973.pdf 2 3 separator 0.6820225 ¶ 180 182 W4392657973.pdf 2 4 text 0.9991239 "Differential thermal analysis (DTA) and thermogravimetric analysis (TGA) were recorded using a SDT Q600 (New Castle, USA) using heating rate 5◦C/min in the tempera- ture range from 40◦C to 600◦C." 182 382 W4392657973.pdf 2 5 separator 0.9046784 ¶ 382 384 W4392657973.pdf 2 6 text 0.9995764 "X-ray diffraction analysis was carried out on a Dron-7 X-ray diffractometer (Saint Petersburg, Russia). A 2 θangle interval from 7◦to 40◦with scanning step ∆2θ= 0.02◦ and exposure of 7 s per point were used. Cu K αradiation (Ni filter) was used, which was subsequently decomposed into K α1 and K α2 components during processing of the spectra [19]." 384 741 W4392657973.pdf 2 7 separator 0.94428337 ¶ 741 743 W4392657973.pdf 2 8 text 0.99950325 "Photophysical experiments: UV/Vis light absorption spectra were recorded using a spectrophotometer UV-1800 (Shimadzu, Kyoto, Japan). The emission spectra were reg- istered using an Avantes AvaSpec-2048 ×64 spectrometer (Avantes, Apeldoorn, The Netherlands). The absolute emission quantum yield was determined using an integrating sphere AvaSphere-50 (Avantes, Apeldoorn, The Netherlands). An LED (365 nm) (Ocean Optics, Largo, FL, USA) was applied for pumping. A pulse laser LDH-P-C-405 (wavelength 405 nm, pulse width 50 ps, repetition frequency 10 MHz) (PicoQuant, Berlin, Germany), a photon counting head H10682-01 (Hamamatsu, Hamamatsu, Japan), a multiple-event time digitizer MCS6A1T4 (FAST ComTec, Oberhaching, Germany), and a monochromator Monoscan-2000 (interval of wavelengths 1 nm) (Ocean Optics, Largo, FL, USA) were used for lifetime measurements. Temperature control was performed by using a cuvette sample compartment qpod-2e (Quantum Northwest Inc., Liberty Lake, WA, USA)." 743 1754 W4392657973.pdf 2 9 separator 0.9662278 ¶ 1754 1756 W4392657973.pdf 2 10 text 0.9994208 "Antimicrobial activity ( in vitro ) was evaluated completely as previously described by some of us [ 20–22]. The DPPH •scavenging effect was evaluated according to the published procedure [23]." 1756 1954 W4392657973.pdf 2 11 separator 0.99668545 ¶ 1954 1956 W4392657973.pdf 2 12 title 0.99107206 3. Results and Discussion 1956 1982 W4392657973.pdf 2 13 separator 0.9948535 ¶ 1982 1984 W4392657973.pdf 2 14 title 0.9935368 3.1. Preparation of Rhodamine B-Containing Films 1984 2033 W4392657973.pdf 2 15 separator 0.9956107 ¶ 2033 2035 W4392657973.pdf 2 16 text 0.99963945 "The chitosan-based Rhodamine B-containing films were prepared using the conven- tional solution casting method. The chitosan which was used in the current study (MW = 40 kDa) is not water-soluble. We dissolved the chitosan in 1% acetic acid solution. Acetic acid protonates primary amino groups of the chitosan, thus, destroying the native interchained hydrogen bonds system. This, in turn, results in the complete dissolution of chitosan." 2035 2483 W4392657973.pdf 2 17 separator 0.85725784 ¶ 2483 2485 W4392657973.pdf 2 18 text 0.9995364 "To improve the flexibility and mechanical properties of the resultant films, we used glycerol as a common plasticizer for polysaccharide-based films. The volume of glycerol added to the chitosan solution was determined based on the literature data to achieve the desired film properties [ 20]. To the chitosan solution containing the plasticizer, we added a solution of Rhodamine B under vigorous stirring. The initial colorless chitosan/plasticizer solution immediately turned purple. One notable observation was that no heterogeneity was observed in the solution even at a temperature of 80◦C, indicating the uniform distribution of Rhodamine B in the chitosan matrix. This could be attributed to the strong stirring during the mixing process, which ensured a homogeneous dispersion of the dye in the solution." 2485 3316 W4392657973.pdf 2 19 separator 0.95512664 ¶ 3316 3318 W4392657973.pdf 2 20 text 0.9991089 "In the same manner described above, we prepared the blank films, which were ob- tained by the same procedures except the addition of the dye Rhodamine B. The resultant solutions were cast in plastic dishes and dried under different conditions which are pre- sented schematically as follows:" 3318 3615 W4392657973.pdf 2 21 separator 0.9832102 ¶ 3615 3617 W4392657973.pdf 2 22 text 0.58070356 "1. Dried at 60◦C for 24 h (films A and A’)*; 2. Dried at 60◦C for 24 h and then 90◦C for 2 h (films B and B’); 3. Dried at 60◦C for 24 h, then treatment of the film using 20% NH" 3617 3799 W4392657973.pdf 2 23 table 0.43145338 3in Et 3799 3806 W4392657973.pdf 2 24 text 0.4377283 OH 3806 3808 W4392657973.pdf 2 25 table 0.45197782 solution 3808 3817 W4392657973.pdf 2 26 text 0.47136393 ¶ 3817 3819 W4392657973.pdf 2 27 table 0.41797164 and 3819 3823 W4392657973.pdf 2 28 text 0.51436 drying at room temperature (films 3823 3857 W4392657973.pdf 2 29 table 0.42626727 C 3857 3859 W4392657973.pdf 2 30 text 0.41630873 "and C’); 4. *—the abbreviations A, B," 3859 3899 W4392657973.pdf 2 31 table 0.34000415 and C belong to 3899 3915 W4392657973.pdf 2 32 text 0.37901878 the 3915 3919 W4392657973.pdf 2 33 table 0.35075805 blank films 3919 3931 W4392657973.pdf 2 34 text 0.32320592 while 3931 3937 W4392657973.pdf 2 35 table 0.3293904 A 3937 3939 W4392657973.pdf 2 36 text 0.3465178 ’, 3939 3941 W4392657973.pdf 2 37 table 0.33892655 B 3941 3943 W4392657973.pdf 2 38 text 0.36776796 "’, and C’ belong to the rhodamine-containing films." 3943 3996 W4392657973.pdf 2 0 title 0.9878354 Data Analysis 0 13 W2762756570.pdf 2 1 separator 0.9953936 ¶ 13 15 W2762756570.pdf 2 2 text 0.99836695 "The constant comparison method was used to analyze the tweets to reduce the data into manageable units and coded information [14-16]. The process began with open coding, which can be defined as “the process of breaking down, examining, comparing, conceptualizing, and categorizing data,” where 2 trained researchers (NS and MH) open-coded all the tweets and disco vered major themes [14-16]. The tweets were then selecti vely coded into those major themes by the same 2 trained researchers (MH and NS; [14-16]). Open coding was done byhand versus using keyword searches through data mining softw are to take on the full conte xt of the tweets/posts." 15 683 W2762756570.pdf 2 3 separator 0.9963964 ¶ 683 685 W2762756570.pdf 2 4 title 0.9142667 Results 685 693 W2762756570.pdf 2 5 separator 0.99482477 ¶ 693 695 W2762756570.pdf 2 6 text 0.99713844 "The constant comparison method initially revealed 23 different tweet categories among the 15,236 tweets analyzed, as displayed in Table 1. Each of these categories were then analyzed and coded into four separate themes: informing and education, monitoring health status and trends, social justice, and professional development (Textbox 1)." 695 1045 W2762756570.pdf 2 7 separator 0.9971904 ¶ 1045 1047 W2762756570.pdf 2 8 title 0.78955513 Table 1. Tweet categories of public health 1047 1091 W2762756570.pdf 2 9 table 0.9817077 "professionals. Tweets, n Tweet category 4032 Non-public health–related 2008 Health nutrition 1885 Other 815Conference/F orum/APHAa 789 Ebola 728 Noninfectious diseases 627ACAb/Health care 626 Violence/Safety/Social justice 567 Health law and polic y 553 Technology/Inno vation 380 Environmental health/F actors 346Charity/Or ganizations/NPOc 250 Vaccines 233 Education and literac y 196 Global famine/W ater 176 Emer gency/Emer gency preparedness 170 Global poverty/Homelessness 158 Infectious diseases 156 Mental health 143HIVd/AIDSe 143 Smoking/T obacco/Marijuana 143 Medications/Drugs and alcohol 112 Influenza 15,236 Total aAPHA: American Public Health Association. bACA: Affordable Care Act. cNPO: nonprof it organization. dHIV: human immunodef icienc y virus. eAIDS: acquired immunodef icienc y syndrome." 1091 1961 W2762756570.pdf 2 10 separator 0.9947548 ¶ 1961 1963 W2762756570.pdf 2 11 paratext 0.96225023 "JMIR Public Health Surveill 2017 | vol. 3 | iss. 4 | e54 | p. 3 https://publichealth.jmir .org/2017/4/e54/ (page number not for citation purposes)Hart et al JMIR PUBLIC HEAL TH AND SURVEILLANCE" 1963 2159 W2762756570.pdf 2 12 separator 0.48619545 2159 2160 W2762756570.pdf 2 13 paratext 0.80090284 ¶ XSL•FO 2160 2168 W2762756570.pdf 2 14 separator 0.5571408 ¶ 2168 2170 W2762756570.pdf 2 15 paratext 0.7712762 RenderX 2170 2178 W2762756570.pdf 2 0 bibliography 0.9965985 "Yinhan Liu, Myle Ott, Naman Goyal, Jingfei Du, Man- dar Joshi, Danqi Chen, Omer Levy, Mike Lewis, Luke Zettlemoyer, and Veselin Stoyanov. 2019." 0 147 W3030520728.pdf 7 1 separator 0.9161699 ¶ 147 149 W3030520728.pdf 7 2 bibliography 0.99672145 "Roberta: A robustly optimized bert pretraining ap- proach. arXiv preprint arXiv:1907.11692 ." 149 244 W3030520728.pdf 7 3 separator 0.9747474 ¶ 244 246 W3030520728.pdf 7 4 bibliography 0.99734384 "Kyle Lo, Lucy Lu Wang, Mark Neumann, Rodney Kin- ney, and Daniel S. Weld. 2020. S2ORC: The Se- mantic Scholar Open Research Corpus. In Proceed- ings of ACL ." 246 410 W3030520728.pdf 7 5 separator 0.9810478 ¶ 410 412 W3030520728.pdf 7 6 bibliography 0.9975736 "Michael Loevinsohn, Lyla Mehta, Katie Cuming, Alan Nicol, Oliver Cumming, and Jeroen HJ Ensink." 412 510 W3030520728.pdf 7 7 separator 0.6729672 ¶ 510 512 W3030520728.pdf 7 8 bibliography 0.99758005 "2015. The cost of a knowledge silo: a systematic re-review of water, sanitation and hygiene interven- tions. Health policy and planning , 30(5):660–674." 512 669 W3030520728.pdf 7 9 separator 0.9804604 ¶ 669 671 W3030520728.pdf 7 10 bibliography 0.99061126 "Microsoft. 2020. Azure cognitive search - covid-19 search demo. https:// covid19search :azurewebsites :net/ . Last accessed 2020-05-12." 671 813 W3030520728.pdf 7 11 separator 0.9491496 ¶ 813 815 W3030520728.pdf 7 12 bibliography 0.9961233 "NIH. 2020. Nih litcovid. https: //www :ncbi :nlm :nih :gov/research/ coronavirus/ . Last accessed 2020-05-12." 815 929 W3030520728.pdf 7 13 separator 0.9843919 ¶ 929 931 W3030520728.pdf 7 14 bibliography 0.9948641 "Raj Kumar Pan, Kimmo Kaski, and Santo Fortunato. 2012. World citation and collaboration networks: uncovering the role of geography in science. Scien- tific reports , 2:902." 931 1109 W3030520728.pdf 7 15 separator 0.9782375 ¶ 1109 1111 W3030520728.pdf 7 16 bibliography 0.995032 "Olle Persson, Rickard Danell, and J Wiborg Schneider. 2009. How to use bibexcel for various types of bib- liometric analysis. Celebrating scholarly communi- cation studies: A Festschrift for Olle Persson at his 60th Birthday ." 1111 1346 W3030520728.pdf 7 17 separator 0.97982913 ¶ 1346 1348 W3030520728.pdf 7 18 bibliography 0.99771094 "Connie Schardt, Martha B Adams, Thomas Owens, Sheri Keitz, and Paul Fontelo. 2007. Utilization of the pico framework to improve searching pubmed for clinical questions. BMC medical informatics and decision making , 7(1):16." 1348 1580 W3030520728.pdf 7 19 separator 0.9833547 ¶ 1580 1582 W3030520728.pdf 7 20 bibliography 0.9977192 "Arnab Sinha, Zhihong Shen, Yang Song, Hao Ma, Dar- rin Eide, Bo-June Hsu, and Kuansan Wang. 2015." 1582 1682 W3030520728.pdf 7 21 separator 0.60935646 1682 1683 W3030520728.pdf 7 22 bibliography 0.9887626 "¶ An overview of microsoft academic service (mas) and applications. In Proceedings of the 24th inter- national conference on world wide web , pages 243– 246." 1683 1846 W3030520728.pdf 7 23 separator 0.97662866 ¶ 1846 1848 W3030520728.pdf 7 24 bibliography 0.9977114 "Mauro Sozio and Aristides Gionis. 2010. The community-search problem and how to plan a suc- cessful cocktail party. In Proceedings of the 16th ACM SIGKDD international conference on Knowl- edge discovery and data mining , pages 939–948." 1848 2093 W3030520728.pdf 7 25 separator 0.9845619 ¶ 2093 2095 W3030520728.pdf 7 26 bibliography 0.9973437 "Marie B Synnestvedt, Chaomei Chen, and John H Holmes. 2005. Citespace ii: visualization and knowledge discovery in bibliographic databases. In AMIA Annual Symposium Proceedings . American Medical Informatics Association." 2095 2324 W3030520728.pdf 7 27 separator 0.97675085 ¶ 2324 2326 W3030520728.pdf 7 28 bibliography 0.9973769 "Franck Touret and Xavier de Lamballerie. 2020. Of chloroquine and covid-19. Antiviral Research , page 104762.Jingxuan Tu, Marc Verhagen, Brent Cochran, and James Pustejovsky. 2020. Exploration and discov- ery of the covid-19 literature through semantic visu- alization. arXiv preprint arXiv:2007.01800 ." 2326 2640 W3030520728.pdf 7 29 separator 0.9819012 ¶ 2640 2642 W3030520728.pdf 7 30 bibliography 0.98721594 "Daniel Tunkelang. 2009. Faceted search , volume 5. Morgan & Claypool Publishers." 2642 2725 W3030520728.pdf 7 31 separator 0.9452652 ¶ 2725 2727 W3030520728.pdf 7 32 bibliography 0.99750465 "Nees Van Eck and Ludo Waltman. 2010. Software sur- vey: V osviewer, a computer program for bibliomet- ric mapping. Scientometrics ." 2727 2863 W3030520728.pdf 7 33 separator 0.9753082 ¶ 2863 2865 W3030520728.pdf 7 34 bibliography 0.9856906 "Daril A Vilhena, Jacob G Foster, Martin Rosvall, Jevin D West, James Evans, and Carl T Bergstrom. 2014. Finding cultural holes: How structure and culture diverge in networks of scholarly communi- cation. Sociological Science , 1:221." 2865 3107 W3030520728.pdf 7 35 separator 0.9744854 ¶ 3107 3109 W3030520728.pdf 7 36 bibliography 0.99786526 "Caroline S Wagner and Loet Leydesdorff. 2005. Net- work structure, self-organization, and the growth of international collaboration in science. Research pol- icy, 34(10):1608–1618." 3109 3296 W3030520728.pdf 7 37 separator 0.9834455 ¶ 3296 3298 W3030520728.pdf 7 38 bibliography 0.9977387 "Byron C Wallace, Jo ̈el Kuiper, Aakash Sharma, Mingxi Zhu, and Iain J Marshall. 2016. Extracting pico sen- tences from clinical trial reports using supervised distant supervision. The Journal of Machine Learn- ing Research . Available from drevidence :com." 3298 3563 W3030520728.pdf 7 39 separator 0.9835713 ¶ 3563 3565 W3030520728.pdf 7 40 bibliography 0.99774754 "Lucy Lu Wang, Kyle Lo, Yoganand Chandrasekhar, Russell Reas, Jiangjiang Yang, Darrin Eide, Kathryn Funk, Rodney Kinney, Ziyang Liu, William Merrill, et al. 2020a. Cord-19: The covid-19 open research dataset. arXiv preprint arXiv:2004.10706 ." 3565 3815 W3030520728.pdf 7 41 separator 0.97328734 ¶ 3815 3817 W3030520728.pdf 7 42 bibliography 0.9977467 "Qingyun Wang, Xuan Wang, Manling Li, Heng Ji, and Jiawei Han. 2020b. Knowledge extraction to assist scientific discovery from corona virus literature. http://blender :cs :illinois :edu/ covid19/ . Last accessed 2020-05-12." 3817 4047 W3030520728.pdf 7 43 separator 0.98290503 ¶ 4047 4049 W3030520728.pdf 7 44 bibliography 0.99794656 "Jevin D West, Jennifer Jacquet, Molly M King, Shel- ley J Correll, and Carl T Bergstrom. 2013. The role of gender in scholarly authorship. PloS one , 8(7)." 4049 4209 W3030520728.pdf 7 45 separator 0.97608125 ¶ 4209 4211 W3030520728.pdf 7 46 bibliography 0.9978157 "Ryen W White and Resa A Roth. 2009. Exploratory search: Beyond the query-response paradigm. Syn- thesis lectures on information concepts, retrieval, and services , 1(1):1–98." 4211 4392 W3030520728.pdf 7 47 separator 0.98335737 ¶ 4392 4394 W3030520728.pdf 7 48 bibliography 0.9967983 "Peace Ossom Williamson and Christian IJ Minter. 2019. Exploring pubmed as a reliable resource for scholarly communications services. Journal of the Medical Library Association: JMLA , 107(1):16." 4394 4595 W3030520728.pdf 7 49 separator 0.98177135 ¶ 4595 4597 W3030520728.pdf 7 50 bibliography 0.9977865 "Wenpu Xing and Ali Ghorbani. 2004. Weighted pager- ank algorithm. In Proceedings. Second Annual Con- ference on Communication Networks and Services Research, 2004. , pages 305–314. IEEE." 4597 4790 W3030520728.pdf 7 51 separator 0.9804156 ¶ 4790 4792 W3030520728.pdf 7 52 bibliography 0.9977342 "Ka-Ping Yee, Kirsten Swearingen, Kevin Li, and Marti Hearst. 2003. Faceted metadata for image search and browsing. In Proceedings of the SIGCHI con- ference on Human factors in computing systems , pages 401–408." 4792 5012 W3030520728.pdf 7 0 paratext 0.976465 "Kehr et al. BMC Bioinformatics 2014, 15:99 Page 11 of 20 http://www.biomedcen tral.com/1471-2105/15/99" 0 104 W2066047071.pdf 10 1 separator 0.9890573 ¶ 104 106 W2066047071.pdf 10 2 text 0.9922719 "by edges e=(v,v)(see blocks B, C, D, F, G, H, and J in Figure 4). The numbers impose a strict total ordering ≺ on all genome segments s1,s2∈Swhere s1≺s2ifs1is left ofs2." 106 282 W2066047071.pdf 10 3 separator 0.86062056 ¶ 282 284 W2066047071.pdf 10 4 text 0.9991701 "Cactus graphs are not as independently used as the other genome alignment graphs. The cactus method oper- ates on two graphs, the cactus graph and another graph called the adjacency graph [40]. Interestingly, the lat- ter has the same structure as an Enredo graph. We view the cactus graph, which enables the characterizationand detection of new substructures, as a supergraph on top of the Enredo graph. The transformation of Enredo graph structures to cactus graph structures conformswith the construction of a cactus graph [22,40] and does not require additional labels. The transformation back to Enredo graphs is ambiguous as the above mentioned examples from Figure 4 show. For this reason, our descrip- tion of this transformation uses the sparse labeling /lscript adjin addition to the graph structure." 284 1121 W2066047071.pdf 10 5 separator 0.9873103 ¶ 1121 1123 W2066047071.pdf 10 6 text 0.9861485 "Cactus graphs from Enredo graphs .T o t r a n s f o r m a n Enredo graph structure G/prime=(V/prime,E/prime B∪E/prime A)into a cac- tus graph structure G=(V,E), we follow three steps described in [22,40]. First, we transform the Enredo graph into a precursor cactus graph. The second and third steps modify the precursor to ensure the structural propertiesof cactus graphs. The second step guarantees that every edge is part of at most one simple cycle. After the third step, the graph is Eulerian. Throughout all steps, we make use of a many-to-one mapping m:V /prime→Vfrom Enredo graph vertices V/primeto cactus graph vertices V, which labels each Enredo graph vertex v/prime∈V/primewith a cactus graph vertex v∈Vsuch that m[v/prime]=v." 1123 1890 W2066047071.pdf 10 7 separator 0.96941555 ¶ 1890 1892 W2066047071.pdf 10 8 text 0.9952764 "First, compute all adjacency-edge connected components CAin the Enredo graph structure G/prime.E a c hc o m p o n e n t C∈CAis a subset of the vertices V/prime.F o re a c h C∈CA, add a vertex to the set of cactus graph vertices V. Assum- ing that the start and end of all genomes are connected, add only one origin vertex for all of them to V.W eo b t a i n the many-to-one mapping that indicates the cactus vertex representing the adjacency edge connected component of any Enredo graph vertex. Given this mapping, transfer theEnredo graph block edges E Bto the cactus graph: For each edge e/prime={u/prime,v/prime}in the set of Enredo graph block edges EB,w h e r e m[u/prime]=uandm[v/prime]=v,a d da ne d g e e={u,v} to the set of cactus graph edges E. It is possible that u=v even if u/prime/negationslash=v/prime. This yields the precursor cactus graph in Figure 4." 1892 2790 W2066047071.pdf 10 9 separator 0.96793234 ¶ 2790 2792 W2066047071.pdf 10 10 text 0.9987863 "In the second step, remove sets of vertices from Vthat are 3-edge-connected and add instead a single vertex vto V(vertices αandβin Figure 4). Correct the mapping m and redirect block edges that were incident to any ver- tex in the 3-edge connected component, to be incident tov.Finally, replace connected components formed only by edges whose removal disconnect the graph (not presentin Figure 4). Each such component is a tree with leaf and branching vertices v 1,...,vc.R e m o v e v1,...,vcand add instead a new vertex vtoV. Just as before, correct the mapping mand redirect incident block edges to v." 2792 3417 W2066047071.pdf 10 11 separator 0.9805802 ¶ 3417 3419 W2066047071.pdf 10 12 title 0.67768943 Cactus graphs 3419 3433 W2066047071.pdf 10 13 text 0.9875058 "to Enredo graphs . In the transformation from a cactus graph structure G=(V,E)to an Enredo graph structure G/prime=(V/prime,E/prime B∪E/prime A),w eu s et h el a b e l s /lscriptadj to separate the sets of adjacencies represented by cactus graph vertices Vand to add edges E/prime Athat represent sin- gle adjacencies to the Enredo graph structure. In addition, we create a one-to-one edge mapping m:E→E/prime Bthat labels each cactus graph edge e∈Ewith an Enredo graph block edge e/prime b∈E/prime Bwhere e/prime b={u/prime,v/prime}. In this mapping, we store a direction of each Enredo graph block edge anddistinguish the tail vertex u /primefrom the head vertex v/primesuch that m[e]=(u/prime,v/prime). The direction is not present in the Enredo graph structure G/prime. The transformation proceeds by threading the genomes Gthrough G." 3433 4312 W2066047071.pdf 10 14 separator 0.94599473 ¶ 4312 4314 W2066047071.pdf 10 15 text 0.97462773 "Initially, identify among all cactus graph edges incident to the origin vertex u∈Vthe edge e0={u,v}whose label contains the smallest number n0∈/lscriptadj(e0)where n0n0butn1Lb,s e eS u p p l e m e n t a r y Figure S3), which corresponds to a trivial phase of zero." 1513 1644 W4211116781.pdf 4 40 separator 0.9729042 ¶ 1644 1646 W4211116781.pdf 4 41 text 0.99765843 Note that a method was recently proposed to experimentallymeasure the Zak phase of an LC coupled circuit network viaprobing the bulk quantities [18]. 1646 1796 W4211116781.pdf 4 42 separator 0.96758413 ¶ 1796 1798 W4211116781.pdf 4 43 text 0.99603766 "We can obtain the spectrum of eigenmodes of the finite- sized circuit for different choices of L aand Lbby calcu- lating the eigenvalues ( ω2)o ft h ed y n a m i c a lm a t r i x D= C−1/2WC−1/2b a s e do nt h em e t h o dg i v e ni n[ 1 7 ,2 0 ] .H e r e , C andWa r et h ec a p a c i t a n c em a t r i xa n di n v e r s ei n d u c t i v i t y matrix of the finite-sized circuit, respectively. SupplementaryMaterials Note 3 presents the detailed derivation process. InSupplementary Figure S4a, two separated modes (magentacolor) can be clearly identified from the gaps of three bulkmodes (blue color, Supplementary Figure S4a), while theyare absent from the trivial case when the values of L aand Lbare exchanged (Supplementary Figure S4b). These two distinct topological states cannot adiabatically transformbetween each other unless the bandgap closes by settingL a=Lb(Supplementary Figure S4c). All the above theoretical a n a l y s e sf u r t h e rc o n fi r mt h a tt h ee d g em o d ei sn o tar e s u l to fatrivial surface effect, but a manifestation of the bulk nontrivialtopological phase." 1798 2920 W4211116781.pdf 4 44 separator 0.9960377 ¶ 2920 2922 W4211116781.pdf 4 45 title 0.9807234 2.2. Experimental Validation of Topological Properties. 2922 2978 W4211116781.pdf 4 46 text 0.9987264 "It can be expected, according to the bulk-boundary correspon- dence, that our 2D SSH circuit supports an edge modelocalized at the four edges in the nontrivial regime. Tosupport this expectation, we design and fabricate a circuitboard which incorporates 7 .25 ×7 .25 unit cells, as shown by the photographs in Figures 2(a) and 2(b), and also the schematicsin Figures 2(c) and 2(d). Here, for simplicity, the capacitorsa n di n d u c t o r sa r er e p r e s e n t e db yt h eb l a c ks p h e r ea n dblue/red lines, respectively. Inductors ( Q∼37 at 40MHz) and capacitors with the same values as the numerical simulationsa r es e l e c t e df o rt h ec o n s t r u c t i o no ft h er e a ls a m p l e .A nS M Aconnector is branched out from each node to facilitate the measurement of the absorption spectra. To minimize the influence of parasitic parameters on the circuit performance and meanwhile to take into consideration the operational frequency range of the VNA (Keysight N5230C, 10MHz to40 GHz), the value of circuit elements is deliberately chosenfor the resonance to fall in the range between 10 and 60 MHz." 2978 4111 W4211116781.pdf 4 47 separator 0.9804012 ¶ 4111 4113 W4211116781.pdf 4 48 text 0.999381 The circuit layout is carefully designed such that the parasiticparameters (i.e., parasitic capacitances and inductances) dueto the adjacent lines have negligible effect on the topologicalproperties. 4113 4313 W4211116781.pdf 4 49 separator 0.97728616 ¶ 4313 4315 W4211116781.pdf 4 50 text 0.9974498 "Reflectance measurement was firstly carried out to exper- imentally characterize the 2D SSH circuit. The absorp-tion spectrum, which represents the amount of RF energy pumped into the circuit, can be simply obtained from 1−S 2 11 [23]. As the reflectance coefficient S11is measured with a 50 Ohm coaxial cable, it reaches zero (linear scale) when the input impedance of a certain node equals 50 Ω,l e a d i n gt o a maximum absorptance of unity. The expected edge modedistribution is illustrated in Figure 2(c), where the RF energy" 4315 4863 W4211116781.pdf 4 0 paratext 0.86731964 Probabilistic Concurrency Testing for Weak Memory Programs 0 58 W4318541601.pdf 1 1 separator 0.94823444 ¶ 58 60 W4318541601.pdf 1 2 contact 0.99630386 "Mingyu Gao m.gao-2@student.tudelft.nl Delft University of Technology Delft, NetherlandsSoham Chakraborty s.s.chakraborty@tudelft.nl Delft University of Technology Delft, NetherlandsBurcu Kulahcioglu Ozkan b.ozkan@tudelft.nl Delft University of Technology Delft, Netherlands" 60 352 W4318541601.pdf 1 3 separator 0.9939944 ¶ 352 354 W4318541601.pdf 1 4 title 0.98385113 ABSTRACT 354 363 W4318541601.pdf 1 5 separator 0.9948462 ¶ 363 365 W4318541601.pdf 1 6 text 0.9995839 "The Probabilistic Concurrency Testing (PCT) algorithm that pro- vides theoretical guarantees on the probability of detecting concur- rency bugs does not apply to weak memory programs. The PCT algorithm builds on the interleaving semantics of sequential con- sistency, which does not hold for weak memory concurrency. It is because weak memory concurrency allows additional behaviors that cannot be produced by any interleaving execution." 365 815 W4318541601.pdf 1 7 separator 0.885067 ¶ 815 817 W4318541601.pdf 1 8 text 0.9993342 "In this paper, we generalize PCT to address weak memory con- currency and present Probabilistic Concurrency Testing for Weak Memory (PCTWM). We empirically evaluate PCTWM on a set of well-known weak memory program benchmarks in comparison to the state-of-the-art weak memory testing tool C11Tester. Our results show that PCTWM can detect concurrency bugs more fre- quently than C11Tester." 817 1218 W4318541601.pdf 1 9 separator 0.9967443 ¶ 1218 1220 W4318541601.pdf 1 10 title 0.97834 CCS CONCEPTS 1220 1233 W4318541601.pdf 1 11 separator 0.97339153 ¶ 1233 1235 W4318541601.pdf 1 12 text 0.90347755 "•Software and its engineering →Concurrent programming structures ;Software testing and debugging ." 1235 1336 W4318541601.pdf 1 13 separator 0.9940435 ¶ 1336 1338 W4318541601.pdf 1 14 title 0.9662868 KEYWORDS 1338 1347 W4318541601.pdf 1 15 separator 0.96181405 ¶ 1347 1349 W4318541601.pdf 1 16 text 0.57582587 Con 1349 1353 W4318541601.pdf 1 17 title 0.43651244 currency 1353 1361 W4318541601.pdf 1 18 text 0.5837864 , Weak memory, Random 1361 1382 W4318541601.pdf 1 19 title 0.42452022 ized 1382 1386 W4318541601.pdf 1 20 text 0.55776954 algorithms, Testing 1386 1406 W4318541601.pdf 1 21 separator 0.86078763 ¶ 1406 1408 W4318541601.pdf 1 22 paratext 0.9680498 ACM Reference Format: 1408 1430 W4318541601.pdf 1 23 separator 0.7124907 ¶ 1430 1432 W4318541601.pdf 1 24 paratext 0.94344723 "Mingyu Gao, Soham Chakraborty, and Burcu Kulahcioglu Ozkan. 2023. Prob- abilistic Concurrency Testing for Weak Memory Programs. In Proceedings of the 28th ACM International Conference on Architectural Support for Pro- gramming Languages and Operating Systems, Volume 2 (ASPLOS ’23), March 25–29, 2023, Vancouver, BC, Canada. ACM, New York, NY, USA, 14pages. https://doi.org/10.1145/3575693.3575729" 1432 1840 W4318541601.pdf 1 25 separator 0.9911634 ¶ 1840 1842 W4318541601.pdf 1 26 title 0.9892401 1 INTRODUCTION 1842 1857 W4318541601.pdf 1 27 separator 0.99502534 ¶ 1857 1859 W4318541601.pdf 1 28 text 0.9943169 "In the multicore era, shared memory concurrency plays a key role in improving performance in these architectures. To program these architectures efficiently, the programming languages are introduc- ing first-class concurrency primitives [ 4,6,12,18,19,33] to provide platform-independent abstractions on the hardware and processors. These concurrency primitives empower programmers to achieve greater performance from the architectures. However, program- ming with these primitives is often error-prone due to their subtle semantics. More specifically, these primitives, as well as the archi- tectures, exhibit additional behaviors that cannot be explained by ¶" 1859 2539 W4318541601.pdf 1 29 paratext 0.96364945 "ASPLOS ’23, March 25–29, 2023, Vancouver, BC, Canada ©2023 Copyright held by the owner/author(s). ACM ISBN 978-1-4503-9916-6/23/03. https://doi.org/10.1145/3575693.3575729" 2539 2717 W4318541601.pdf 1 30 bibliography 0.7456451 "traditional thread interleaving semantics, aka sequential consis- tency (SC). These behaviors are known as weak memory behaviors, and these concurrency models are known as weak memory models." 2717 2912 W4318541601.pdf 1 31 separator 0.9897332 ¶ 2912 2914 W4318541601.pdf 1 32 text 0.99948287 "Concurrency poses a significant challenge to testing and verifi- cation approaches, considering the number of possible executions even under interleaving semantics. Verification techniques perform sound analyses, but they scale poorly. On the other hand, testing approaches scale better but lacks soundness. Though concurrency testing lacks soundness in general, it is always desirable to achieve some guarantees on the effectiveness of a testing approach." 2914 3383 W4318541601.pdf 1 33 separator 0.97481704 ¶ 3383 3385 W4318541601.pdf 1 34 text 0.9996161 "The Probabilistic Concurrency Testing (PCT) algorithm [ 8] is a randomized concurrency testing algorithm for SC programs that provides strong theoretical guarantees on the probability of detect- ing bugs. The probabilistic guarantees of PCT rely on the notion of bug depth , i.e., the minimum number of ordering constraints between the concurrent events in a program. Given bug depth das a test parameter, PCT characterizes the set of executions with dordering constraints and samples a test execution from that set. Focusing on the executions with a certain bug depth significantly reduces the sample set. Unlike naive random testing algorithms that detect a concurrency bug with a probability that is exponentially low in the number of program events n, PCT guarantees a probability that is exponentially low only in d." 3385 4231 W4318541601.pdf 1 35 separator 0.9504214 ¶ 4231 4233 W4318541601.pdf 1 36 text 0.99950796 "In this scenario, a natural question arises: can we apply PCT for testing weak memory programs? We investigate this question in this paper and observe that the theoretical guarantee of the PCT algorithm does not apply to testing weak memory programs. It is because weak memory concurrency relaxes the SC requirements and allows a more extensive set of program behaviors, many of which cannot be produced by any interleaving executions in SC." 4233 4687 W4318541601.pdf 1 37 separator 0.7356539 ¶ 4687 4689 W4318541601.pdf 1 38 text 0.99961567 "More specifically, the PCT algorithm builds on the notion of bug depth that is designed for the interleaving semantics of sequential consistency, which does not capture weak memory concurrency." 4689 4887 W4318541601.pdf 1 39 separator 0.9579755 ¶ 4887 4889 W4318541601.pdf 1 40 text 0.9993701 "In this paper, we generalize PCT to address weak memory con- currency and present Probabilistic Concurrency Testing for Weak Memory (PCTWM). For this, we revise the definition of concurrency bug depth and generalize it to capture weak memory concurrency." 4889 5150 W4318541601.pdf 1 41 separator 0.97825253 ¶ 5150 5152 W4318541601.pdf 1 42 text 0.99899614 "We define bug depth as the minimum number of communication relations between the concurrent events in an execution regardless of their scheduling order. We show that the traditional definition of bug depth under SC corresponds to a specific case of our definition, in which the communication relations correspond to the thread interleavings." 5152 5504 W4318541601.pdf 1 43 separator 0.9212936 ¶ 5504 5506 W4318541601.pdf 1 44 text 0.9995189 "Based on our bug depth definition, we devise the PCTWM al- gorithm that extends the theoretical guarantees of PCT for weak memory concurrency. Similar to PCT, PCTWM provides a theo- retical lower bound on the probability of detecting concurrency bugs that is exponential only in the depth bound d. Different from PCT, which samples a test execution with dordering requirements ," 5506 5895 W4318541601.pdf 1 45 separator 0.84080434 ¶ 5895 5897 W4318541601.pdf 1 46 paratext 0.96202356 "This work is licensed under a Creative Commons Attribution 4.0 Interna- tional License. 603" 5897 5993 W4318541601.pdf 1 47 separator 0.9809158 ¶ 5993 5995 W4318541601.pdf 1 0 paratext 0.98391235 1806 Journal of Petroleum Exploration and Production Technology (2020) 10:1803–1816 0 83 W3020470835.pdf 3 1 separator 0.8711609 ¶ 83 85 W3020470835.pdf 3 2 paratext 0.9855068 1 3 85 89 W3020470835.pdf 3 3 separator 0.9931706 ¶ 89 91 W3020470835.pdf 3 4 text 0.99627835 "in the relatively closed deep lacustrine environment with insufficient supply of terrigenous clastic material. The depo-sition rate is relatively low and the laminar structure is com-monly found in the organic-rich shale. Mudstone is generally formed in the semi-deep lacustrine environment where the supply of terrigenous clastic material is relatively sufficient, and the deposition rate is relatively high (Yuan et al 2015). The organic-rich mudstone has no obvious laminar struc-ture, which is the difference between mudstone and shale in structure. Based on the observation of the structure and construction of core samples, the organic-rich fine-grained sedimentary rock samples were classified (Fig. 3). Organic- rich shale is mainly black with laminar structure, and the samples are fragile under stress (Fig. 3a–c). Organic-rich mudstone is mainly dark gray-black with blocky structure (Fig. 3d, 3e), and carbonized plant debris can be found occa- sionally in the mudstone samples (Fig. 3f)." 91 1106 W3020470835.pdf 3 5 separator 0.8672054 ¶ 1106 1108 W3020470835.pdf 3 6 text 0.99424976 "In order to study the characteristics of Chang7 organic- rich fine-grained sedimentary rocks in Longdong area, organic petrological, and molecular geochemical experi-ments were carried out. Additionally, molecular geochemi-cal experiments on tight oil samples were carried out." 1108 1388 W3020470835.pdf 3 7 separator 0.99483514 ¶ 1388 1390 W3020470835.pdf 3 8 title 0.9832929 Organic petrological analyses 1390 1420 W3020470835.pdf 3 9 separator 0.9939213 ¶ 1420 1422 W3020470835.pdf 3 10 text 0.99971807 The organic petrology experiments rely on the OGE-VI Rock–Eval Pyrolysis and Polarizing Microscope from the Key Laboratory of Technology for Oil and Gas Resources, Ministry of Education, Yangtze University and the MAT-253 Stable Isotope Mass Spectrometer from the Isotope 1422 1694 W3020470835.pdf 3 11 separator 0.9932072 ¶ 1695 1697 W3020470835.pdf 3 12 caption 0.99603707 Fig. 3 Core samples of organic-rich fine-grained sedimentary rocks 1697 1765 W3020470835.pdf 3 0 paratext 0.952677 Pedagonal : Jurnal Ilmiah Pendidikan  5 0 50 W4380199756.pdf 4 1 separator 0.5980866 "¶ ¶" 50 59 W4380199756.pdf 4 2 paratext 0.8341821 Academic Achievement Research in High School : A Bibliometric Analysis | Galizty , et.al. 59 150 W4380199756.pdf 4 3 separator 0.9939146 ¶ 152 154 W4380199756.pdf 4 4 text 0.97711325 "Analysis based on the subject area in Scopus, shows that the literature related to Academic achievement is divided into 11 fields of study, which can be seen in full in Figure 1." 155 340 W4380199756.pdf 4 5 separator 0.99134535 ¶ ¶ 341 347 W4380199756.pdf 4 6 caption 0.9795158 Figure 1. Document by subject area 347 382 W4380199756.pdf 4 7 separator 0.9829727 ¶ 384 386 W4380199756.pdf 4 8 title 0.97977585 Publication Outputs by Years 386 415 W4380199756.pdf 4 9 separator 0.9865592 ¶ 417 419 W4380199756.pdf 4 10 text 0.78590685 RQ 1 : How many articles about Academic achievement were published in 2003 -2021? 419 501 W4380199756.pdf 4 11 separator 0.92149377 ¶ 503 505 W4380199756.pdf 4 12 text 0.9859974 "Table 2. Shows the year of publication during the literature review period. The average journal articles published as a whole for the 2003 -2021 period were 1.94 documents. The increase in the number of publications from 2003 to 2021 shows a significant increase. On the other hand, 2011 was the highest num ber of publications with 6 documents. A similar trend indicates that for the 2021 period (for the first semester) there will be the same or a greater number of publications than the previous term." 505 1026 W4380199756.pdf 4 13 separator 0.99692595 ¶ 1028 1030 W4380199756.pdf 4 14 title 0.81283295 Table 2. Publication Output by Year (2003 -2021 1030 1078 W4380199756.pdf 4 15 table 0.54284495 ) 1078 1079 W4380199756.pdf 4 16 separator 0.9030588 ¶ 1081 1083 W4380199756.pdf 4 17 table 0.9926108 "Publication by Y ears Records % of 37 2021 2 5,40 2019 3 8,10 2018 2 5,40 2017 4 10,81 2016 2 5,40 2015 4 10,81 2013 2 5,40 2012 3 8,10 2011 6 16,21 2010 1 2,70 2009 3 8,10 2006 2 5,40 2005 1 2,70 2004 1 2,70 2003 1 2,70 Social Sciences (44.8%) Psychology (15.5%) Medicine (6.9%) Agricultural an.. (5.2%) Arts and Humanity (5.2%) Economics (3.4%) Engineering (3.4%) Nursing (3.4%) Biochemistry. G (1.7%) Computer Science (1.7%) Other (8.6%)" 1083 1633 W4380199756.pdf 4 0 paratext 0.8986907 Dash et al. /one.tnum/zero.tnum./three.tnum/three.tnum/eight.tnum/nine.tnum/fpsyg./two.tnum/zero.tnum/two.tnum/two.tnum./nine.tnum/one.tnum/seven.tnum/nine.tnum/five.tnum/nine.tnum 0 180 W4288695367.pdf 2 1 separator 0.89450806 ¶ 180 182 W4288695367.pdf 2 2 bibliography 0.9576886 "in the aging population (Olsen et al., 2015; Keijzer and Schmid, 2016; Papageorgiou et al., 2019; Soltani et al., 2021) ." 182 306 W4288695367.pdf 2 3 separator 0.99157953 ¶ 306 308 W4288695367.pdf 2 4 text 0.9986514 "The reason for the inconsistency may originate in the way groups are labeled and thus classified. Surrain and Luk (2019) highlights different ways in which researchers have classified their bilingual group; it was evident that 77% of the studies use the label “ bilingual” or “specific language pair bilingual, ” and only minimal studies (19%) use combination of factors to label the bilingual group. Another evolutionary transition was understanding variations in cognitive performance within bilingual groups. Various behavioral and neuroimaging studies have compared two extremes of the population within the bilingualcategory—highvs.lowproficiency (SinghandMishra, 2013), balanced vs. unbalanced (Woumans et al., 2015) , early vs. late(Tao et al., 2011) . Although such an approach still categorizes the participants into two groups, it has led to much informative literature on bilingualism. The debatable role of bilingualism in cognitive performance also stems from the variabilityinbilingualexperiences;forexample,ahighproficient bilingual may be an early or late bilingual, or an early bilingual maybeanunbalancedbilingual.Therefore,thepredictionmade using one set of observable variables (for example, proficiency) does not apply to another set of observable variables (for example, language usage), thus limiting reliable and replicable researchfindings." 308 1710 W4288695367.pdf 2 5 separator 0.9813634 ¶ 1710 1712 W4288695367.pdf 2 6 text 0.9991375 "Recent studies have used statistical methods to mathematically combine and use continuous variables to predict changes in cognitive performance (Gullifer et al., 2018; Dashetal.,2019,2022) .Moreover,theuseofstatisticalmethods to determine outcomes for the measure of bilingualism has found support in a recent study by Macdonald et al. (2022) ." 1712 2067 W4288695367.pdf 2 7 separator 0.97734094 ¶ 2067 2069 W4288695367.pdf 2 8 text 0.99929994 "Authors find convergence between outcomes from various statistical methods (like confirmatory factor analyses and latent profile analyses) and another continuous metric of bilingualism (Vaughn and Hernandez, 2018) and self-reported information (Macdonald et al., 2022) . Since bilingualism is a multidimensional construct, there can be an overlapping continuum of different measures of bilingualism. Similarly, a bilingual continuum created using one dimension of bilingual experience (for example, language usage, DeLuca et al., 2019) may have a different trajectory in another dimension." 2069 2672 W4288695367.pdf 2 9 separator 0.9787363 ¶ 2672 2674 W4288695367.pdf 2 10 text 0.9993711 "Furthermore, the lack of consensus in bilingual literature also stems from the differences in how different measurement tools are used to study bilingualism. Therefore, it is crucial to determine which task and stimuli are used as measures of bilingualism, and once scholars determine the variables of interest, the next logical step is to figure out how they use them to understand the role of bilingualism in cognitive performance. Depending on the research questions, researchers have often used 1 or 2 measures to categorize participants into different groups; more recent studies use different bilingualism measures on a continuum. Categorizing participants in groups allows for simplification of the analyses, presentation, and interpretationoftheresultsfromastudy (DeCosteretal.,2011) .The data presentation is easier by dichotomizing the variables using a table or graph with the mean scores to demonstrate differences between groups. However, If the predictor variable is continuous, then the slope of the predictor variable with the outcome variable needs to be presented using regression lines. For example, to explore the interaction effect between age and bilingualism on cognitive performance, a researcher may construct distinct regression lines between bilingualism and cognitive performance for different age cohorts (young vs. older adults) and interpret the effect. In addition, when age and bilingualism vary continuously, the statistical approach to presentation needs to be tweaked. Such methods are more complicatedthanpresentinggroupmeans.Similarly,categorical analysis is typically more straightforward and traditional than continuous analysis. ANOVA, which requires a categorical predictor variable, is more commonly used by psychologists to test influences on an outcome variable. However, the linear mixed effect model (Gallo et al., 2022) and growth curve analysis(Incera and McLennan, 2017) are gaining popularity in recent times where multiple continuous variables can also be consideredtopredicttheoutcome.Somepotentialargumentsin favorofcategorizationwereprovidedby FarringtonandLoeber (2000). They propose that arbitrarily categorizing variables is one method for dealing with variables with highly skewed distributions or when the relationship between predictor and outcome variable is not linear. However, there are more cons than pros in using measures of bilingualism to categorize participants. To begin with, conducting group analyses when the variable of interest may vary on a continuum diminishes statistical power and increases the risk of rejecting the null hypothesis (Cohen, 1983; Altman and Royston, 2006; DeCoster et al., 2011) . Secondly, universally accepted grouping criteria are unavailable, limiting the reproducibility of the results in different studies (Altman and Royston, 2006) . Especially with the aging population, categorizing participants based on the current language usage and proficiency may ignore the necessary bilingual experience (spanning over decades) crucial forbuildinganaccuratebilingualprofile.Furthermore,suppose the split is made at an arbitrary cut-off point (say, the median age of acquisition of 10 years). In that case, participants with an age of acquisition of 9 and 11 years are placed in different groups, even though they may be more like each other than othermembersoftheirgroup(i.e.,ageofacquisitionof9yearsis more similar to that of 11 years than that of 1 year; MacCallum etal.,2002;AltmanandRoyston,2006 )." 2674 6269 W4288695367.pdf 2 11 separator 0.9906145 ¶ 6269 6271 W4288695367.pdf 2 12 text 0.9955039 "To summarize, grouping bilinguals when the underlying construct is continuous has statistical implications and may obfuscate our understanding of the measure of bilingualism in theresearchstudy.Itiscomparativelyeasytogroupparticipants; however, it adds researchers’ bias to the study. Finally, when groups are constructed based on the values of a continuous measure,asignificantamountofinformationandvariabilitythat mayexistwithinagrouparelost (MacCallumetal.,2002) .Inthe followingsections,wewillelaborateonthemostcommonlyused " 6271 6817 W4288695367.pdf 2 13 paratext 0.8338642 Frontiersin Psychology /zero.tnum/three.tnum frontiersin.org 6817 6877 W4288695367.pdf 2 0 paratext 0.86744696 289 Skilling / Barrett / Kurian | Evidence, interests and argumentation: an environmental poli cy... 0 100 W4206159465.pdf 24 1 separator 0.9718176 ¶ 100 102 W4206159465.pdf 24 2 title 0.98839015 Actors advocating the return of the river to the estuary 102 159 W4206159465.pdf 24 3 separator 0.9947571 ¶ 159 161 W4206159465.pdf 24 4 title 0.6065566 "Forms of evidenceRepresentative Quote(s)" 161 205 W4206159465.pdf 24 5 separator 0.9419454 ¶ 205 207 W4206159465.pdf 24 6 title 0.5160465 Preference 207 218 W4206159465.pdf 24 7 text 0.92277235 "for situated knowledge‘Local residents have more knowledge of problems in the estuary, than any present study can accurately assess” (Wilkinson, in BOP Times, 1984b)." 218 394 W4206159465.pdf 24 8 separator 0.98627496 ¶ 394 396 W4206159465.pdf 24 9 title 0.61880404 Critique of 396 408 W4206159465.pdf 24 10 text 0.44353595 ¶ 409 411 W4206159465.pdf 24 11 title 0.49568418 “ 411 413 W4206159465.pdf 24 12 text 0.9491078 "objective” scientific expertise‘Unfortunately officialdom refuses to seek the advice of local experience and makes unfounded predictions without ever having set foot on the tidal reaches of the estuary” (Wilkinson, in BOP Times, 1984b)." 413 661 W4206159465.pdf 24 13 separator 0.9122673 ¶ 661 663 W4206159465.pdf 24 14 text 0.99654627 "The BOPCC ignored ‘a lot of important social information’ and the ‘frames of reference for the [BOPCC] study were so limited it was natural the study would rule out a full return of the river to the estuary [since] the study looked at things only in an economic and technical way’ (Loomis, in RDP , 1986c)." 663 979 W4206159465.pdf 24 15 separator 0.9259536 ¶ 980 982 W4206159465.pdf 24 16 text 0.98534 "‘The Maketu people had never been consulted. Nor had the potential effects of full diversion on the community been addressed’ (Wilkinson, in RDP , 1986c)." 982 1140 W4206159465.pdf 24 17 separator 0.95400894 ¶ 1140 1142 W4206159465.pdf 24 18 bibliography 0.5848295 The BO 1142 1149 W4206159465.pdf 24 19 text 0.59341556 PCC 1149 1152 W4206159465.pdf 24 20 bibliography 0.5381828 Report ‘was 1152 1164 W4206159465.pdf 24 21 text 0.90058583 "theoretical and a waste of money’ (MAG, in RDP , 1986d)." 1164 1224 W4206159465.pdf 24 22 separator 0.9597256 ¶ 1224 1226 W4206159465.pdf 24 23 text 0.9928388 "Loomis said: ‘parts of the [BOPCC Report] were offensive to the Maori people’ since the Report ‘questioned their ability to remember the estuary as it was and ... took a cavalier attitude to Maori legends and cultural heritage. The im - plication was that such input was unreliable for planning purposes’ (Loomis, in RDP , 1986d)." 1226 1566 W4206159465.pdf 24 24 separator 0.9280195 ¶ 1566 1568 W4206159465.pdf 24 25 text 0.95042735 "‘The Maori people have been insulted by the misquoting of our history’ (Wilkinson, in BOP Times, 1986c)." 1568 1676 W4206159465.pdf 24 26 separator 0.8878044 ¶ 1676 1678 W4206159465.pdf 24 27 text 0.9933186 "‘Further technical studies will only serve to cloud contentious issues, waste time, money and energy’ since these ‘technical studies’ are costly and ‘only supply theoretical unsubstantiated findings’ (MAG, in Te Puke Times, 1986b)." 1678 1916 W4206159465.pdf 24 0 text 0.9633945 "foster correct valuation, coverage, and appropriate payment, and support a reasonable range of business models and sites ofservice." 0 133 W4310781642.pdf 1 1 separator 0.9498074 ¶ 133 135 W4310781642.pdf 1 2 text 0.99644315 "The taxonomy is applicable to both Category I and Category III CPT codes. Category I CPT codes provide a uniform language forcoding medical services and procedures and Category III CPT codes are a set of temporary codes that allow data collection for emerging technologies, services, procedures, and service para-digms. As the “work done by machines ”increasingly contributes to the provision and intensity of medical services, the taxonomy is meant to facilitate proper and accurate CPT coding, so the integration of AI into tracking, coverage, and payment systemsevolves in a consistent manner. This will help facilitate patient access to the technology and accurate payment to physicians." 135 841 W4310781642.pdf 1 3 separator 0.9368525 ¶ 841 843 W4310781642.pdf 1 4 text 0.99863625 "In some cases, rather than reducing physician input, the complexity of the output from AI may counterintuitively increase physician work, which currently may not be transparent in coding,coverage, and payment. The taxonomy is a framework intended toengender descriptors which are discrete and differentiable. Ideally, the resultant coding will do more than simply characterize the “work done by the machine ”along the spectrum of “assistive, ” “augmentative, ”and “autonomous, ”but will also delineate the machine ’s part in the medical service and impact on the subsequent human work in such a way that the coding, coverage,and payment for the services will fairly re flect the contribution of each as shown in Table" 843 1576 W4310781642.pdf 1 5 title 0.9843234 1.CURRENT CONTEXT 1576 1594 W4310781642.pdf 1 6 separator 0.9907076 ¶ 1594 1596 W4310781642.pdf 1 7 text 0.98104566 "The AI Taxonomy, published on the AMA website and made effective from January 2022, provides guidance for choices oflanguage for descriptors for AI-related CCAs 3. It is intended that all AI-related CCA ’s would be drafted and assessed with knowledge of the AI taxonomy henceforth, and descriptors used consistentlyacross like codes." 1596 1938 W4310781642.pdf 1 8 separator 0.95412564 ¶ 1938 1940 W4310781642.pdf 1 9 text 0.99621 "When applicants submit a CCA for an AI-related code, the code change requestor should include technical details necessary tosupport the CPT Editorial Panel ’s conclusion as to where the technology fits in the CPT-de fined hierarchy of “assistive ”, “augmentative ”, and “autonomous ”. Developers should consult the AI Taxonomy when developing descriptors for other highlysophisticated software. For example, Magnetic Resonance Spec-troscopy is a highly sophisticated software, not the result ofmachine learning as is typical of products like the IDx-DR diabeticretinopathy device discussed supra , but instead is an “expert system ”which renders data understandable in terms of inter- mediary metabolism associated with pathophysiology 10. Such analysis of data is quite different, and adds more value, thansimple image reconstruction. These types of “expert systems ”may meet the criteria within the hierarchy of the taxonomy. As anotherexample, deriving an estimate of Fractional Flow Reserve fromcoronary CT is considered augmentative because the quantitativeoutput is clinically meaningful, ie understood by physicians to be directly applicable in optimizing the patient ’s care pathway." 1940 3150 W4310781642.pdf 1 10 separator 0.99717844 ¶ 3150 3152 W4310781642.pdf 1 11 title 0.9856484 WHY NO DEFINITION OF THE TERM “AI”? 3152 3188 W4310781642.pdf 1 12 separator 0.992717 ¶ 3188 3190 W4310781642.pdf 1 13 text 0.99952 "In health care, there is no single product, procedure, nor service for which the term “AI”is suf ficient or necessary to describe its intended clinical use or utility; a nd therefore, the speci fict e r m “AI”is not defined in the AI Taxonomy nor elsewhere in the CPT code set. The term “AI”is not intended to encompass nor constrain the full scope of innovations performing “work done by machines ”,n o ra r et h e s e anthropomorphic terms intended to convey that the physician is being “replaced ”" 3190 3702 W4310781642.pdf 1 14 separator 0.9948652 ¶ 3702 3704 W4310781642.pdf 1 15 title 0.44245514 11Classi fication of 3704 3724 W4310781642.pdf 1 16 text 0.3217972 AI 3724 3727 W4310781642.pdf 1 17 title 0.3577257 medical services and proce- 3727 3755 W4310781642.pdf 1 18 text 0.25929892 ¶ 3755 3757 W4310781642.pdf 1 19 title 0.37360287 dures 3757 3763 W4310781642.pdf 1 20 bibliography 0.36287573 as assistive, augmentativ e, and autonomous is 3763 3810 W4310781642.pdf 1 21 text 0.2960531 3810 3811 W4310781642.pdf 1 22 bibliography 0.5131655 based on the 3811 3823 W4310781642.pdf 1 23 text 0.36086088 ¶ 3823 3825 W4310781642.pdf 1 24 bibliography 0.52729785 "clinical procedure or service prov ided to the patient, and the work performed by the machine on behalf of the physician or other QHP" 3825 3961 W4310781642.pdf 1 25 text 0.39165652 . 3961 3962 W4310781642.pdf 1 26 separator 0.99058294 ¶ 3962 3964 W4310781642.pdf 1 27 title 0.99062234 "GRANULARITY FOR EACH OF ASSISTIVE, AUGMENTATIVE, AND AUTONOMOUS" 3964 4030 W4310781642.pdf 1 28 separator 0.98602784 ¶ 4030 4032 W4310781642.pdf 1 29 text 0.9931157 "This AI taxonomy is guidance for classifying various applications of AI (expert systems, machine learning, software-based services, etc.) medical services and procedures into one of three categories:FDA Product" 4032 4247 W4310781642.pdf 1 30 separator 0.64007145 ¶ 4248 4250 W4310781642.pdf 1 31 title 0.6207174 Descrip/g415onCPT Code 4250 4273 W4310781642.pdf 1 32 table 0.42560318 ¶ 4274 4276 W4310781642.pdf 1 33 title 0.5952706 "DescriptorsCMS Coverage and Payment" 4276 4315 W4310781642.pdf 1 34 separator 0.9709102 ¶ 4316 4318 W4310781642.pdf 1 35 caption 0.9707045 "Fig. 1 The continuum of AI CPT code descriptors. Appendix S is intended to enable discrete and differentiable code descriptors byaccurately characterizing the “work done by machines ”relative to the work of the physician or other quali fied health care professional." 4318 4588 W4310781642.pdf 1 36 separator 0.7454747 ¶ 4588 4590 W4310781642.pdf 1 37 text 0.9928603 "Therefore, these same descriptors may be useful also in regulatory labeling of novel products like “Software as a Medical Device ” (SaMD) and in valuation, coverage and payment policy for theassociated novel services or procedures, like “Software as a Service ” (SaaS)." 4590 4866 W4310781642.pdf 1 38 separator 0.99672073 ¶ 4866 4868 W4310781642.pdf 1 39 title 0.96354526 Table 1. The relationship between components of the service and categorization. 4868 4948 W4310781642.pdf 1 40 separator 0.9632776 ¶ 4948 4950 W4310781642.pdf 1 41 table 0.95642793 "Service components AI Category: Assistive AI Category: Augmentative AI Category: Autonomous Primary Objective Detects clinically relevant data Analyzes and/or quanti fies data in a clinically meaningful wayInterprets data and independently generates clinically meaningfulconclusions Provides independent diagnosis and/or management decisionNo No Yes Analyzes data No Yes Yes Requires physician or other QHP interpretation and reportYes Yes No" 4950 5410 W4310781642.pdf 1 42 separator 0.6751157 ¶ 5410 5412 W4310781642.pdf 1 43 table 0.79018825 "Examples in CPT code set Computer-aided detection (CAD) imaging (77048, 77049, 77065 –77067, 0042 T, 0174 T, 0175 T)Non-invasive estimate of coronary fractional flow reserve derived from coronary CT (7X005, effective Jan 2024, https://www.ama-assn.org/system/files/september-2022-cpt-summary- panel-actions.pdf )Retinal imaging (92229)" 5412 5758 W4310781642.pdf 1 44 separator 0.9651654 ¶ 5758 5760 W4310781642.pdf 1 45 paratext 0.9725999 "R.A. Frank et al. 2 npj Digital Medicine (2022) 177 Published in partnership with Seoul National University Bundang Hospital1234567890():,;" 5760 5906 W4310781642.pdf 1 0 paratext 0.81113964 13 0 2 W4232048468.pdf 12 1 separator 0.97181904 ¶ 3 5 W4232048468.pdf 12 2 text 0.9985335 "interface. The improvement is attributed to the unique effect of the incorporated water on altering the 3D network structure of 65RH, which increases efficient channel s for transportation of Li+ ions and electrons ." 6 234 W4232048468.pdf 12 3 separator 0.9820888 ¶ 236 238 W4232048468.pdf 12 4 text 0.99960285 "To gain further insight into the reaction kinetics of both the dry and the hydrated glass- based anode s, we performed CV measurements on the ‘dry’ and the 65RH samples within the window of 0.01 ~ 3.0 V at different scan rates from 0.1 to 2 mV s-1 (Figs. 4a and b ). This is one of the effective approach es to investigate the electrochemical reaction kinetics of electrode materials for Li+ storage [44,45] . A recent study revealed that the capacity generation of a silicate glass -ceramic anode involves two lithium- ion storage mechanisms [46]. One is the lithium insertion reaction , while the other is related to both ion diffusion and surface induced capacitance. In the present work , we determine the degree of surface induced capacitive effect of the studied anodes using the relationship between the measured current (i) and sweep rate ( v) of the CV curves , i.e., i = avb, where a and b are adjustable parameters ." 238 1209 W4232048468.pdf 12 5 separator 0.98606396 ¶ 1210 1212 W4232048468.pdf 12 6 text 0.9996627 "The b value is in the range between 0.5 and 1.0. The b value of 0.5 implies a diffusion- controlled process . The totally stored charge comes from lithium insertion process. In contrast , b=1 suggests an ideally capacitance- controlled process , which take s place mostly on the surface of electrode [47]. A value between 0.5 and 1 implie s the mixed contribution from both the diffusion- controlled process and the capacitive effect. In Figs. 4a and b, the CV curves of the dry and 65RH samples show that both the potential difference of the redox peak s and the peak current increase with increasing the scan rate. As demonstrated in Fig. 4c, the current s of the five pairs of cathodic/anodic peaks for TVP anode show a linear dependence on square root of the scan rate. The b values for the cathodic and anodic scans are determined t o be 0.69 and 0.71, respectively, revealing that the capacity of TVP anode arises" 1212 2172 W4232048468.pdf 12 0 paratext 0.9788976 1 0 1 W3011739768.pdf 0 1 separator 0.61145675 ¶ 1 3 W3011739768.pdf 0 2 paratext 0.9769078 Scientific REPORtS | 7:46124 | DOI: 10.1038/srep46124www.nature.com/scientificreports 3 91 W3011739768.pdf 0 3 title 0.9010051 "Corrigendum: Ectopic expression of Arabidopsis Target of Rapamycin" 91 161 W3011739768.pdf 0 4 text 0.36400133 ¶ 162 164 W3011739768.pdf 0 5 title 0.6547757 (AtTOR) improves water-use 164 191 W3011739768.pdf 0 6 text 0.53101516 ¶ 192 194 W3011739768.pdf 0 7 title 0.54701304 efficiency and yield potential in rice 194 233 W3011739768.pdf 0 8 separator 0.9930436 ¶ 233 235 W3011739768.pdf 0 9 bibliography 0.98856634 "Achala Bakshi , Mazahar Moin , M. Udaya Kumar , Aramati Bindu Madhava Reddy , Maozhi Ren , Raju Datla, E. A. Siddiq & P . B. Kirti" 235 370 W3011739768.pdf 0 10 separator 0.5491827 ¶ 370 372 W3011739768.pdf 0 11 bibliography 0.8934267 Scientific Reports 7:42 372 397 W3011739768.pdf 0 12 paratext 0.47902432 835 397 400 W3011739768.pdf 0 13 bibliography 0.8793869 ; doi: 10.1038/srep 400 419 W3011739768.pdf 0 14 paratext 0.5178211 42835 419 424 W3011739768.pdf 0 15 bibliography 0.80745995 ; published online 424 442 W3011739768.pdf 0 16 paratext 0.5161045 23 442 445 W3011739768.pdf 0 17 bibliography 0.5614607 445 446 W3011739768.pdf 0 18 paratext 0.59575176 February 2017 446 459 W3011739768.pdf 0 19 bibliography 0.6295493 ; updated on 459 471 W3011739768.pdf 0 20 paratext 0.6613597 10 April 2017 471 485 W3011739768.pdf 0 21 separator 0.99488735 ¶ 485 487 W3011739768.pdf 0 22 text 0.77745765 "This Article contains errors in the Affiliations of Maozhi Ren and Raju Datla. The correct affiliations for these authors are listed below:" 487 630 W3011739768.pdf 0 23 separator 0.9923508 ¶ 630 632 W3011739768.pdf 0 24 contact 0.9731982 "Maozhi Ren Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, P .R. China; School of Life Sciences, Chongqing University, Chongqing, P .R. China." 632 817 W3011739768.pdf 0 25 separator 0.6976791 ¶ 817 819 W3011739768.pdf 0 26 contact 0.9843031 "Raju Datla Plant Biotechnology Institute, National Research Council of Canada, Saskatoon, Saskatchewan, S7N 0W9, Canada." 819 945 W3011739768.pdf 0 27 separator 0.9887449 ¶ 945 947 W3011739768.pdf 0 28 paratext 0.8772765 "This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/" 947 1434 W3011739768.pdf 0 29 separator 0.7802418 ¶ ¶ 1434 1440 W3011739768.pdf 0 30 paratext 0.9735889 © The Author(s) 2017OPEN 1440 1465 W3011739768.pdf 0 0 title 0.58959836 For Peer Review Only 0 20 W4286499392.pdf 1 1 table 0.99340105 "023 66 Male Liver cancer unk. 024 56 Male Liver cancer unk. 025 56 Male Liver cancer unk. 026 61 Female Lung cancer unk. 027 64 Male Liver cancer unk. 028 65 Female Breast cancer unk. 029 58 Female Gastric adenocarcinoma unk. 030 80 Female Liver cancer unk. 031 56 Male Liver cancer unk. 032 64 Female Rectum cancer unk. 033 78 Female Rectum adenocarcinoma II 034 47 Female Breast cancer unk. 035 53 Male Liver cancer III 036 74 Female Gastric adenocarcinoma III 037 48 Male Rectum adenocarcinoma I 038 65 Male Thyroid cancer unk. 039 79 Female Lung cancer unk." 20 608 W4286499392.pdf 1 2 separator 0.99159646 ¶ 608 610 W4286499392.pdf 1 3 text 0.8054789 a. Tumor stage was based on TNM system. ‘unk.’ indicates that the information was not collected. 610 707 W4286499392.pdf 1 4 paratext 0.9874391 Page 25 of 25 707 720 W4286499392.pdf 1 5 separator 0.9814253 ¶ 720 722 W4286499392.pdf 1 6 contact 0.5516982 http:// 722 730 W4286499392.pdf 1 7 paratext 0.57814187 mc. 730 733 W4286499392.pdf 1 8 contact 0.48674193 m 733 734 W4286499392.pdf 1 9 paratext 0.6781273 anuscriptcentral 734 750 W4286499392.pdf 1 10 contact 0.4754756 . 750 751 W4286499392.pdf 1 11 paratext 0.6168621 com/ 751 755 W4286499392.pdf 1 12 contact 0.47699252 tan 755 758 W4286499392.pdf 1 13 paratext 0.5960267 df/sjcli 758 766 W4286499392.pdf 1 14 contact 0.91068584 Editorial office e-mail: editorial.office@sjcli.orgThe Scandinavian Journal of Clinical & Laboratory Investigation 766 882 W4286499392.pdf 1 15 separator 0.98405474 ¶ 882 884 W4286499392.pdf 1 16 paratext 0.5292323 "1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60" 884 1173 W4286499392.pdf 1 0 caption 0.9375355 "Tab. 1 Changes in bond distances ( ∆i−jgiven in Angstroms) with respect to geometry optimized without the presence of confining potential ( ω= 0)" 0 148 W1940295939.pdf 1 1 separator 0.6922399 ¶ 148 150 W1940295939.pdf 1 2 table 0.9022266 "ω CO2 HCCH HCN ∆C−O ∆C−C ∆C−H ∆C−N ∆C−H 0.08 -0.003 -0.005 -0.004 -0.004 -0.004 0.16 -0.012 -0.019 -0.015 -0.015 -0.014 0.24 -0.024 -0.036 -0.030 -0.030 -0.028 recognized.28,29" 150 337 W1940295939.pdf 1 3 text 0.99702054 "It has been shown that these contributions in some instances may dominate over the electronic counter- parts. The theoretical prediction of the vibrational corrections to the (hyper)polarizabilities of polyatomic molecules is still challenging for quantum chemistry methods. Usually, the Born-Oppenheimer (BO) approximation is the starting point for computations of the electric properties of molecules (see Ref. 30,31for an example of an alternative nonadiabatic approach for computing (hyper)polarizabilities). Within BO approximation the total energy may be separated into terms related to electronic and nuclear degrees of freedom. Hence, molecular properties may also be divided into the corresponding electronic and vibrational contributions." 337 1109 W1940295939.pdf 1 4 separator 0.9766747 ¶ 1109 1111 W1940295939.pdf 1 5 text 0.9995862 "In this communication, in order to study the effect of spatial confinement on the vibrational contributions to static electric properties, we employed two approaches. Namely, the perturbation method of Bishop and Kirtman was used to determine vibrational corrections based on the double harmonic approximation (hereafter referred to as harmonic contributions)25,32,33while the finite-field nuclear relaxation (FF-NR) method34,35was employed to determine nuclear relaxation hyperpolarizabilities. In the case of the FF-NR method the vibrational correction to electrical property ( PVIB) is interpreted in terms of contributions due to the shift of the equilibrium geometry in the presence of an external electric field (the so-called nuclear relaxation contribution, PNR) and contribution due to the change of the shape of the potential energy surface (the curvature contribution, Pcurv). A comparison and detailed analysis of these two schemes has been discussed many times in the literature.36,37The Pcurv contributions are usually smaller than the PNRcontribution and are not computed here. It is worth to note that the FF-NR method yields first and second hyperpolarizability including electrical and mechanical anharmonicity. All calculations reported in this communication correspond to the static limit (time-independent electric fields are considered). The pure electronic contributions were calculated at the equilibrium geometries using the finite-field method.38The choice of external electric field ( F) strength is particularly important forthe numerical evaluation of energy and property derivatives using finite differences. Thus, in this communication, we use the Romberg-Rutishaser scheme39to determine pure electronic ( PEL) and vibrational (nuclear relaxation, PNR) contributions to the molecular (hyper)polarizabilities, and to control the numerical stability of the results. The linear molecules investigated here (CO 2, HCCH and HCN) were oriented along z-axis in all calculations. The FF-NR treatment was applied only for the dominant longitudinal (along z-axis) components of the static (hyper)polarizabilities." 1111 3304 W1940295939.pdf 1 6 separator 0.9865919 ¶ 3304 3306 W1940295939.pdf 1 7 text 0.9947771 "The model two-dimensional harmonic potential was cen- tered at the molecular axis:2,8,14–16,18" 3306 3403 W1940295939.pdf 1 8 separator 0.89492834 ¶ 3403 3405 W1940295939.pdf 1 9 math 0.9530728 "Vconf(ri)=1 2ω2r2 i=1 2ω2(x2 i+y2 i), (2)" 3405 3457 W1940295939.pdf 1 10 separator 0.96515346 ¶ 3457 3459 W1940295939.pdf 1 11 text 0.99949515 "This type of model confining potential allows to mimic a smoothly varying strength of spatial restriction by setting the value of ω, being the quadratic force constant of the applied harmonic potential. Similarly to our previous study, the range ofωvalues considered in this communication was adjusted to render the exchange repulsion of linear molecules encapus- lated in carbon nanotube and varies from 0 to 0.24 au.15The geometries of the CO 2, HCCH and HCN molecules were fully optimized in vacuum as well as in the presence of the confin- ing potential using the CCSD(T)/aug-cc-pVTZ approach. The same method was applied for calculations of the electrical properties of the investigated molecules. The geometry relaxations in the external confining potential (and electric field) were carried out with the aid of procedure developed by Luis et al.35In this approach the geometry optimization is performed by means of the Broyden-Fletcher-Goldfarb-Shano method based on the numerical energy gradients calculated employing the GAUSSIAN 09 package.40" 3459 4542 W1940295939.pdf 1 12 separator 0.973456 ¶ 4542 4544 W1940295939.pdf 1 13 text 0.9995129 "Since our theoretical predictions cannot be directly com- pared with the available experimental data, we would like to present them in the broad context of experiences and knowl- edge emerging from computational and experimental studies concerning the effects of spatial restriction or high pressure on the individual molecules and molecular materials. It is ob- vious that vibrational contributions to (hyper)polarizabilities of molecules must be particularly influenced by the changes in molecular geometry. Indeed, it has been shown that high pressure induces significant changes of position and intensity of vibrational bands in IR and Raman spectra of molecules in various molecular materials. The direction of the pressure- induced shifts and broadening of vibrational bands depends on the balance between short-range repulsive and long-range at- tractive intermolecular forces.41–48Our theoretical approach based on imposing the model confining potential is related to the situation when strong repulsion and consequent elec- tron density deformation is the dominant effect influencing" 4544 5667 W1940295939.pdf 1 14 separator 0.7896003 ¶ 5667 5669 W1940295939.pdf 1 15 paratext 0.8013714 "2 | 1– 5 Page 2 of 5 Physical Chemistry Chemical Physics" 5669 5728 W1940295939.pdf 1 0 paratext 0.9822228 2021’04 ВЛАСТЬ 21 1 0 30 W4239454766.pdf 4 1 separator 0.9947628 ¶ 30 32 W4239454766.pdf 4 2 text 0.9942021 "С одной стороны, наблюдается объективный процесс, направленный на понижение уровня влияния России. Данную тенденцию можно проследить на основании сокращения употребления в речи монголов русского языка. В первую очередь это относится к молодому поколению, которое отдает пред - почтение изучению английского, китайского, корейского, японского языков [Иркутская школа... 2014 ]." 32 421 W4239454766.pdf 4 3 separator 0.9107661 ¶ 421 423 W4239454766.pdf 4 4 text 0.999315 "Но, с другой стороны, нельзя сказать, что на сегодняшний день Россия не играет важной роли в жизни Монголии и вообще находится где-то на задвор - ках ее интересов. Сегодня, реально оценивая фактическое положение дел в отношениях между нашими странами, эксперты отмечают сравнительно низ - кий торгово-инвестиционный уровень сотрудничества. Например, в 2018– 2010 гг . доля российских инвестиций в монгольскую экономику не превышала 2%. В двусторонней торговле доминирует экспорт товаров преимущественно сырьевого характера." 423 966 W4239454766.pdf 4 5 separator 0.9774592 ¶ 966 968 W4239454766.pdf 4 6 text 0.99953455 "В политическом плане сегодня Монголия во многом ориентирована на Запад. Одним из ключевых элементов внешней политики являются отноше - ния с такими государствами, как США, Япония, Южная Корея. Дальнейший курс страны должен определить важный документ «Дальнее видение – 2050». В этой программе развития Монголии на ближайшие 30 лет (на данный момент пока не утверждена парламентом) заявлена цель превратить Монголию в «одну из ведущих, развитых стран региона»." 968 1445 W4239454766.pdf 4 7 separator 0.9621241 ¶ 1445 1447 W4239454766.pdf 4 8 text 0.9984666 Все эти факторы наводят на неоднозначные размышления. 1447 1501 W4239454766.pdf 4 9 separator 0.98279965 ¶ 1501 1503 W4239454766.pdf 4 10 text 0.9988284 "В ответах на вопрос: «Какая сфера отношений между Россией и Монголией наиболее приоритетна для Монголии?» – 61,4% российских экспертов назы - вают экономику , и лишь 20,5% – политику ." 1503 1693 W4239454766.pdf 4 11 separator 0.68242043 ¶ 1693 1695 W4239454766.pdf 4 12 text 0.9989629 "Но когда вопрос ставится в другой логике: «Какая сфера отношений между Россией и Монголией наиболее приоритетна для России?» – 22,7% экспертов считают, что это экономика, а 63,6% выбирают политическую сферу . От 6,3% до 2,3% экспертов отдают предпочтение военной сфере, образованию, науке и искусству ." 1695 2010 W4239454766.pdf 4 13 separator 0.92571783 ¶ 2010 2012 W4239454766.pdf 4 14 text 0.9984005 "Ответы на идентичные вопросы монгольских экспертов расходятся с россий - скими. Для Монголии, считают они, и экономическая, и политическая сфера почти равноценны (см. рис. 3).." 2012 2194 W4239454766.pdf 4 15 separator 0.9953288 ¶ 2194 2196 W4239454766.pdf 4 16 caption 0.9944755 "Рисунок 3 . Структура ответов монгольскихэкспертов на вопрос: «Какая сфера отншений между Россией и Монголией наиболее приоритетна для Монголии?»" 2196 2345 W4239454766.pdf 4 17 separator 0.9930223 ¶ 2345 2347 W4239454766.pdf 4 18 text 0.9940306 "Такая оценка монгольских экспертов свидетельствует, что Монголии лучше и выгоднее, если Россия останется так называемым «мягким» соседним го -" 2347 2493 W4239454766.pdf 4 0 paratext 0.9905458 8 of 15 0 7 W2990926401.pdf 7 1 separator 0.96074915 ¶ 8 10 W2990926401.pdf 7 2 text 0.9994392 "attributed to the input variables [46]. In Table 5 , the indicated act -R2 of 0.9548 was close to 1. This represent ed 95.48% variability of the predicted response value (Al3+ transport), which is a function of the four process variables. Also, the adj. R2 (0.9358) represents 0.0642 of the variations in the response that cannot be attributed to the significant independent terms. The clear exemption of statistically insignificant terms in the model was through the forward screening method under the condition (p - value≤ α = 0.05)." 11 564 W2990926401.pdf 7 3 separator 0.9962703 ¶ 566 568 W2990926401.pdf 7 4 table 0.4953735 Table 568 574 W2990926401.pdf 7 5 title 0.5525782 5. ANOVA for reduced quadratic 574 606 W2990926401.pdf 7 6 table 0.9431886 "model at 32 -hours . Source Sum of squares Df Mean Squares F-value p-value prob>F Regression model 34.51 8 4.31 50.18 <0.0001 X1-Feed conc. 12.74 1 12.74 148.28 <0.0001 X2-Feed flow 2.49 1 2.49 28.95 <0.0001 X4-Sweep conc. 9.25 1 9.25 107.66 <0.0001 X1X2 1.24 1 1.24 14.38 0.0012 X1X4 3.01 1 3.01 34.97 <0.0001 X12 0.4585 1 0.4585 5.33 0.0323 X22 0.6027 1 0.6027 7.01 0.0159 X42 0.4645 1 0.4645 5.40 0.0313 Residuals 1.63 19 0.0859 Pure Error 0.0018 3 0.0006 Standard deviation = 0.2932; Mean= 8.43; CV %= 3.48; Actual R2= 0.9548; Predicted R2=0.8736 ;Adjusted R2= 0.9358; Adequate Precision = 22.8386" 606 1293 W2990926401.pdf 7 7 separator 0.97021973 ¶ ¶ 1295 1301 W2990926401.pdf 7 8 text 0.99954927 "The ANOVA in Table 5 revealed that the first order ( X1, X 2, X4), two way interaction (X1X2 and X1X4) and pure quadratic effect (X12,X22 and X42) were highly significant for Al3+ transport. More so, the F -value of 50.18 implied the model term wa s stati stically significant and there wa s only 0.01% chance that the large F -value could be due to noise. F -values of the independent variables X1, X 2 and X3 were 148.28, 28.95 and 107.66 respectively. Considering the F -values, the effect of independent variables on Al3+ mobility was therefore high for variables with high F -value. The calcul ated CV of 3.48% further assented to the reliability of the model. A measure of the relative dispersion with respect to the mean provides information on the reproducibility, repeatability and precision of th e model, where ; CV<10% [47,48] . Also, the adequate relationship between the signal –to-noise ratio must exist to inform that the model can be used to navigate the design space. The signal to noise ration given by the adequacy precision, was 22.839 and that was > 4. T herefore the noise level did not compete with useful information from the model." 1301 2507 W2990926401.pdf 7 9 separator 0.99706745 ¶ 2509 2511 W2990926401.pdf 7 10 title 0.99347323 4.1.2 Diagnostic plots 2511 2534 W2990926401.pdf 7 11 separator 0.99678516 ¶ 2536 2538 W2990926401.pdf 7 12 text 0.9995461 "The predicted versus actual normality probability of residuals and the residuals versus run plot are used to evaluate the goodness -of-fit of the model. The good correlation between the actual and predicted mobility is depicted by the well distribution of the actual values to the predicted value line." 2538 2847 W2990926401.pdf 7 13 separator 0.8999593 ¶ 2848 2850 W2990926401.pdf 7 14 text 0.99937844 "The model pred -R2 and adj. R2 within 20% was found to be significantly acceptable. Meloun and Militky [49], suggested that a model could be used after a residual analysis has been performed , whereby the residual analysis is used to investigate outli ers and detect influential observations. In Figure 3a, the diagnostic plot of the model with the predicted R2 of 0.8736 showed that data points were close to the diagonal line. Likewise in Figure 3b, the data points of the residuals follow ed a normal distr ibution as maximum plots are interlocked with the straight line. Furthering the residual analysis, Fig ure 3c showed a conformance to a random non -linear scattering trend along the run number and absenc e of outliers. As such, there was no time related vari able lurking at the background. Whi le the negative residual implies an over prediction, a positive residual indicates a low prediction. A plot close to the estimated regr ession line at zero (0) expounded on the exactness of prediction." 2850 3897 W2990926401.pdf 7 15 paratext 0.9698324 "Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 29 November 2019 doi:10.20944/preprints201911.0370.v1 Peer-reviewed version available at Processes 2020, 8, 160; doi:10.3390/pr8020160" 3898 4119 W2990926401.pdf 7 0 paratext 0.99105185 Vaccines 2022 ,10, 357 8 of 10 0 30 W4214773641.pdf 7 1 separator 0.9927069 ¶ 30 32 W4214773641.pdf 7 2 text 0.9976283 "detected, thus suggesting that the NF9 peptide could induce early immune system acti- vation and efficient cytokine production, leading to a faster immune response, and thus reducing SARS-CoV-2 virus pathogenicity." 32 250 W4214773641.pdf 7 3 separator 0.99660367 ¶ 250 252 W4214773641.pdf 7 4 title 0.9948817 3.3. C/H-CrUPs Altered Architecture around the Spike-Cleavage Site(s) of the Omicron Variant 252 345 W4214773641.pdf 7 5 separator 0.99576855 ¶ 345 347 W4214773641.pdf 7 6 text 0.999661 "The molecular mechanism of Spike protein’s proteolytic activation has been shown to play a crucial role in the selection of host species, virus–cell fusion, and the viral infection of human lung cells [ 13–15]. Spike protein [SPIKE_SARS2 (P0DTC2)] contains three cleavage sites (known as S-cleavage sites) crucial for the virus fusion to the host cell: the R685#S and R815#S positions that serve as direct targets of the Furin protease, and the T696#M position that can be recognized by the TMPRSS2 protease [16–18]." 347 874 W4214773641.pdf 7 7 separator 0.88790345 ¶ 874 876 W4214773641.pdf 7 8 text 0.9996553 "In these cleavage sites, the Omicron variant carries only the critical mutation P681H, which also appears in the Alpha variant (Figure 1B). Strikingly, in contrast to the Delta variant, which contains the P681R mutation, the P681H mutation constructs several new C/H-CrUPs in the Alpha and Omicron variants, thus indicating their dispensable contribu- tion to virus fusion to the host cell (Table 4)." 876 1285 W4214773641.pdf 7 9 separator 0.9972354 ¶ 1285 1287 W4214773641.pdf 7 10 title 0.9540371 Table 4. C/H-CrUPs arround the Spike protein cleavage sites. 1287 1348 W4214773641.pdf 7 11 separator 0.98727596 ¶ 1348 1350 W4214773641.pdf 7 12 table 0.99210155 "Cleavage Site Mutation Variant Position New C/H-CrUPs R685#SP681R Delta 680 SRRRAR #S P681H Alpha Omicron677 QTNSH 678 TNSHR 680 SHRRAR T696#M A701V Beta None R815#S None None None" 1350 1543 W4214773641.pdf 7 13 separator 0.9899908 ¶ 1543 1545 W4214773641.pdf 7 14 text 0.99830526 "C/H-CrUPs around the mutant positions of Spike protein cleavage sites are presented. Symbol “ #” indicates the protein cleavage positions." 1545 1686 W4214773641.pdf 7 15 separator 0.9965919 ¶ 1686 1688 W4214773641.pdf 7 16 title 0.99154556 4. Conclusions 1688 1703 W4214773641.pdf 7 17 separator 0.9967754 ¶ 1703 1705 W4214773641.pdf 7 18 text 0.999673 "Core Unique Peptides constitute a distinct and important group of peptides within a proteome. The identification of CrUPs in an organism (e.g., virus, microbe, or mutant pro- tein) against a distinct proteome of another organism is a completely novel approach, which could prove useful for the understanding of the action of microorganisms, the association of novel pharmacological targets with therapies, and the design of novel vaccines. It could be employed in many different kinds of diseases, such as cancer, athropozoans diseases, the design of vaccines for pathogenic viruses, and the identification of new antigenic epitopes capable for the development of new diagnostic or therapeutic antibodies. Therefore, we applied this dynamic and novel strategy, for the first time, in the identification of CrUPs derived from SARS-CoV-2 against the human proteome [ 1]. In that study, we analyzed all the CrUP peptides of all SARS-CoV-2 variants against the proteome of the host organism, which in our case was Human sapiens . Remarkably, this approach clearly revealed the immune escaping capacity, the contagious power and the high pathogenicity of Delta variant, in contrast to other variants. Notably, these findings have been confirmed by epidemiological data concerning the course of the disease." 1705 3029 W4214773641.pdf 7 19 separator 0.94729793 ¶ 3029 3031 W4214773641.pdf 7 20 text 0.9995761 "In the present study, we engaged this approach to the analysis of the SARS-CoV-2 Omicron variant. The analysis of C/H-CrUP landscapes in the heavily mutated SARS-CoV- 2 Omicron variant Spike protein unveiled that the Omicron variant, by the generation of novel multi-mutated C/H-CrUPs, could escape the immune system defense mechanisms, while these C/H-CrUP-specific mutations could facilitate more efficient virus binding to the ACE2 cellular receptor, and a more productive fusion of the virus to the host cell. Most importantly, in contrast to the Delta variant, the intact NF9 peptide in the Omicron variant," 3031 3654 W4214773641.pdf 7 0 paratext 0.98499453 "International Journal of Trend in Scientific Research and Development (IJTSRD) ISSN: 2456-6470 @ IJTSRD | Available Online @ www.ijtsrd.com | Volume – 2 | Issue – 2 | Jan-Feb 2018 Page: 573" 0 201 W2793576794.pdf 1 1 title 0.9633512 "convection are used to compare the result from with various heat transfer parameter in case hiTRAN tube insert" 202 319 W2793576794.pdf 1 2 text 0.99973476 "Chandrasker et al (2010-2011) conducted the experiments which involve usage of a wire coil insert fitted in circular tube which showed that there was rise in heat transfer rate with insignificant rise in friction factor in plain tube and tube with wire coil inserts. Saqr and Musa (2009) investigated the consequence of repetitive fin discontinuity on convective heat transfer coefficient for pipes with internal longitudinal fins and found that smaller the discontinuity off set distance higher is heat transfer coefficient. Thome (1997) investigated that the proper usage of tubular heat transfer enhancement techniques will be able to minimize the linier dimensions of tube of heat exchanger about 25 to 75% when checked with plain empty tube heat exchanger. Hosseini et al (2007) experimentally studied the heat transfer and pressure drop characteristics of shell and tube heat exchanger by providing various external tube surfaces. The main reason that the shell and tube heat exchangers are generally being employed in energy and chemical industries are due to their moderately simple manufacturing is involved and their flexible in nature of installation to the different operating condition. Manufacturing and operating cost of any heat exchangers are impacted by internally depended parameters for example heat transfer rate, heat transfer coefficient and pressure drop. The modern types of inserts are used on tube side to improve the turbulence so has to enhance the heat transfer coefficient and effectiveness of heat exchanger. The present scenario of increased effect on climatic condition more efficient heat transfer equipments are mandatory for automotive and production industries with heat exchanger compact in size with optimizing heat transfer techniques. The usage of different tabulators on tube side results in improved heat transfer characteristics which reduces the equipment size. The main purpose of this work is to study the enhancement in heat transfer characteristics and its effect on pressure drop using wire matrix inserts under the laminar flow condition in shell and tube heat exchanger." 319 2563 W2793576794.pdf 1 3 separator 0.9934377 ¶ ¶ 2564 2570 W2793576794.pdf 1 4 title 0.9904566 1.1 Introduction to hiTRAN wire matrix inserts: 2570 2619 W2793576794.pdf 1 5 separator 0.9895538 ¶ ¶ 2621 2627 W2793576794.pdf 1 6 text 0.9997441 "Sometimes the problem to be solved is simple-poor thermal performance. Although the heat exchanger designer always aim for high heat transfer coefficient this can sometimes be difficult to achieve with a conventional plain tube design. In many cases this due to the properties of tube side fluid such as high viscosity and low thermal conductivity. Occasionally low heat transfer rates are a consequence of the arrangement of the exchanger such as when single pass tube bundles are require. Whatever the reason, poor tube side performance can usually be avoided by considering the use of heat transfer enhancement technologies. Engineering devices such as hiTRAN matrix elements in variably provides increased heat transfer relative to the plain tube. When fluid flow through the plain tube the fluid nearest to the wall is subjected to the frictional drag which has the effect of slowing down the fluid at the wall this laminar boundary layer can significantly reduce the tube side heat transfer coefficient and consequently the performance of heat exchanger. Inserting correctly the profiled hiTRAN wire matrix element into the tube will disrupt the laminar boundary layer, creating the additional fluid shear and mixing, her by minimizing the effect of frictional drag. hiTRAN wire matrix tabulators are particularly effective at enhancing heat transfer efficiency in tubes operating at low Reynolds number (Laminar to transitional flow). Although heat transfer increase is greatest in the laminar flow region (up to 16 times) significant benefits can be obtained in the transitional flow regime (up to 12 times) and turbulent regime (up to 3 times). Whilst there is an increase in frictional resistance associated with hiTRAN system, the amount of enhancement such that solution can be found which offer increased heat transfer at equivalent or low pressure drop than a plain tube." 2627 4621 W2793576794.pdf 1 7 separator 0.94170326 "¶ ¶" 4622 4632 W2793576794.pdf 1 8 caption 0.9937764 Fig.1 High density hiTRAN inserts. 4632 4667 W2793576794.pdf 1 9 separator 0.99243605 ¶ 4668 4670 W2793576794.pdf 1 0 bibliography 0.90635085 MELLO, P.H.C.; ALTOÉ, S.P.S.; GDIRÃO, G.S.M., et al., revista Matéria, v.29, 0 77 W4392398878.pdf 5 1 paratext 0.68261033 n.1, 2024 77 87 W4392398878.pdf 5 2 separator 0.9952439 ¶ 87 89 W4392398878.pdf 5 3 title 0.9938252 2.4. Determinação da resistência a compressão 89 135 W4392398878.pdf 5 4 separator 0.9965413 ¶ 135 137 W4392398878.pdf 5 5 text 0.99850243 "A resistência à compressão do concreto foi determinada conforme a norma NBR 5739:2018 – Concreto – Ensaio de compressão de corpos e prova cilíndricos [14], com aplicação de carga axial constante de 0,45 MPa por minuto, com variação máxima permitida de 0,15 MPa. O ensaio cessou ao ocorrer queda abrupta no carrega - mento, indicando o rompimento do corpo de prova." 137 510 W4392398878.pdf 5 6 separator 0.5746589 ¶ 510 512 W4392398878.pdf 5 7 text 0.9975389 "Os corpos de prova possuem 10 cm de diâmetro e 20 cm de altura, respeitando as tolerâncias mínimas, dispensando fatores de correção. Foram realizados ensaios em 12 corpos de prova para cada traço de concreto, em duas idades: 56 e 90 dias, com 6 corpos de prova por idade. A determinação da resistência à compressão do concreto é dada pela Equação 1:" 512 871 W4392398878.pdf 5 8 separator 0.77778715 ¶ 871 873 W4392398878.pdf 5 9 math 0.85697865 4. = .cFfDπ (1) 873 889 W4392398878.pdf 5 10 separator 0.88469094 ¶ 889 891 W4392398878.pdf 5 11 text 0.89001644 "Em que: fc = resistência à compressão do concreto (Mpa); F = força máxima alcançada (N); D = diâmetro do corpo de prova (mm)." 891 1023 W4392398878.pdf 5 12 separator 0.7186707 ¶ 1023 1025 W4392398878.pdf 5 13 text 0.99844056 "Também foram medidos os deslocamentos verticais dos CP ́s utilizando de um medidor de desloca - mento, para obtenção do módulo de elasticidade estático do concreto, o ensaio foi realizado conforme dem - ostrado na Figura 6." 1025 1252 W4392398878.pdf 5 14 separator 0.9963186 ¶ 1252 1254 W4392398878.pdf 5 15 caption 0.99473035 Figura 6: Configuração do ensaio de compressão. 1254 1303 W4392398878.pdf 5 0 paratext 0.93787915 "3 Rev Saúde Pública 2013;47(6):1-8" 0 36 W1600253194.pdf 2 1 separator 0.9936399 ¶ 36 38 W1600253194.pdf 2 2 text 0.84803814 "The aim of this study was to analyze the association between the degree of implementation of the Brazilian Breastfeeding Network and the prevalence of exclusive breastfeeding for the first six months." 38 248 W1600253194.pdf 2 3 separator 0.9908721 ¶ 248 250 W1600253194.pdf 2 4 title 0.9825466 METHODS 250 258 W1600253194.pdf 2 5 separator 0.9935956 ¶ 258 260 W1600253194.pdf 2 6 text 0.9945884 "This was a cross-sectional study of 916 infants aged less than six months in Ribeirao Preto, SP, Southeastern Brazil, in August 2011. The data were obtained from the Projeto Amamentação e Municípios – Breastfeeding and Municipalities Project (AMAMUNIC), which since 1998 has annually collected data on breastfeeding practices in infants aged less than 1 year, on the day of the Campanha Nacional de Vacinação contra a Poliomielite – National Poliomyelitis Vaccination Campaign. a This data includes closed questions on consumption of breast milk, other milk and foods, referring to the day preceding the survey." 260 898 W1600253194.pdf 2 7 separator 0.7535873 ¶ 14 898 903 W1600253194.pdf 2 8 bibliography 0.46795994 The 903 907 W1600253194.pdf 2 9 text 0.39581603 ¶ 908 910 W1600253194.pdf 2 10 bibliography 0.5321071 "AMAMUNIC uses current status as this recommended for describing infant feeding practices in order to mini- mize memory bias." 910 1037 W1600253194.pdf 2 11 separator 0.9873793 ¶ 1037 1039 W1600253194.pdf 2 12 title 0.65385437 "17 Characteristics of mother and baby are obtained, including where the routine health care monitoring takes place." 1039 1158 W1600253194.pdf 2 13 separator 0.97381663 ¶ 1158 1160 W1600253194.pdf 2 14 text 0.99848616 "The sample size required was 1,000 infant aged less than 1 year, which would enable the prevalence of different infant health related events to be estimated with 95% certainty, within the confidence intervals of a maximum ± 3.0%; this accuracy was expected for events with a prevalence of 50.0%." 1160 1465 W1600253194.pdf 2 15 separator 0.8256521 ¶ 1465 1467 W1600253194.pdf 2 16 text 0.99840075 "4 The sample was obtained by systematically two stage sampling: first, the (clustered) vaccination points were selected, followed by selecting infants in each location. As all infants had the same probability of belonging to the selected sample, this was considered equiprobabilistic: larger points had a greater chance of being selected in the first stage, and infants at smaller points had a greater chance of being selected in the second stage." 1467 1930 W1600253194.pdf 2 17 separator 0.9007489 ¶ 14 ¶ 1930 1937 W1600253194.pdf 2 18 text 0.996718 "Only infants aged less than six months and born in maternity wards in the municipality of Ribeirao Preto, SP, were included. Those for whom no data was avail - able on place of birth were excluded from the analyses." 1937 2158 W1600253194.pdf 2 19 separator 0.8474014 ¶ 2159 2161 W1600253194.pdf 2 20 text 0.9988595 "A total of 1,755 infants aged less than one year partici - pated in the AMAMUNIC, of which 953 were aged less than six months. Of these, 37 were excluded as they did not meet the eligibility criteria. Thus, 916 infants less than six months were included." 2161 2418 W1600253194.pdf 2 21 separator 0.9830525 ¶ 2418 2420 W1600253194.pdf 2 22 text 0.993508 "Ribeirao Preto, SP, is a medium sized municipality in the northeast of the state of Sao Paulo, 313 km from the state capital." 2420 2552 W1600253194.pdf 2 23 separator 0.6216494 ¶ 2552 2554 W1600253194.pdf 2 24 text 0.8677527 "f In 2011, it had around 618 thousand inhabitants, an infant mortality rate of 9.8 and 11,790 live births, almost all of which took place in hospital.g,h" 2554 2711 W1600253194.pdf 2 25 separator 0.95568115 ¶ 2711 2713 W1600253194.pdf 2 26 text 0.99618244 "The Primary Care network in Ribeirao Preto, SP, has 40 health care units, including 30 PHCU and six family health care units. In 2011, fifteen units took part in the Breastfeeding Network Workshop, eight of them becoming certified." 2713 2954 W1600253194.pdf 2 27 separator 0.8348328 ¶ 2954 2956 W1600253194.pdf 2 28 text 0.9970387 "The following criteria, proposed by the Brazilian Ministry of Health for certifying PHCU, were used: participation of at least 80.0% of the team in the Workshop; monitoring breastfeeding indicators in the area they cover (using the Sistema de Vigilância Alimentar e Nutricional – Food and Nutrition Surveillance System); carrying out at least one campaign agreed in the above mentioned workshop; and creating and implementing a flowchart of mother-baby care during the period of breastfeeding. Each unit in the Network has a tutor responsible for monitoring their development of activities encouraging breastfeeding and for assisting the team in case of difficulties." 2956 3648 W1600253194.pdf 2 29 separator 0.5574741 ¶ 3648 3650 W1600253194.pdf 2 30 text 0.8896307 b 3650 3652 W1600253194.pdf 2 31 separator 0.7288527 ¶ 3652 3654 W1600253194.pdf 2 32 text 0.99748486 "The outcome of this study was exclusive breastfeeding (EB), meaning the infant receives only breast milk, no other types of liquid or solid food.17 The covariates correspond to the characteristics of the infant (age in days, sex: male; female, birth weight: < 2,500 g; 2,500 g and over, type of birth: vaginal or cesarean); and of the mother (age group: < 20; 20 to 35; 35 and over, previous births: first birth; multiparous, work status: working outside the home; not working outside the home; on maternity leave, s'chooling in years of study: ≤ 8; 9 to 11; and 12 or more)." 3654 4248 W1600253194.pdf 2 33 separator 0.9759957 ¶ 4248 4250 W1600253194.pdf 2 34 text 0.9969958 "The factor studied corresponded to where outpatient care took place. These were stratified as follows, dividing the public network into categories that expressed to what degree the Network was established: private; non-Network Public (had not participated in a Breastfeeding Network Workshop and were not certified by the Network); Public with Network Workshop (participated in a Breastfeeding Network Workshop but were not certified by the Network); and Public certified by Network." 4250 4749 W1600253194.pdf 2 35 separator 0.92470366 ¶ 4749 4751 W1600253194.pdf 2 36 text 0.9979792 "The association between independent variables and the response variable was assessed by unadjusted analysis using the Chi-square test. The individualized effect of the factor studied on EB was assessed using Poisson regression analysis with robust variance. Values for the unadjusted prevalence ratios (PR) and their respective 95% confidence intervals (95%CI) were obtained based on this analysis. The Poisson " 4751 5179 W1600253194.pdf 2 37 separator 0.67343915 ¶ f 5179 5182 W1600253194.pdf 2 38 bibliography 0.9870688 "Prefeitura da Cidade de Ribeirão Preto. Dados Geográficos: Ribeirão Preto; 2012 [cited 2012 Sept 28]. Available from: http://www. ribeiraopreto.sp.gov.br/crp/dados/local/i01localacesso.htm" 5182 5373 W1600253194.pdf 2 39 separator 0.85106325 ¶ 5373 5376 W1600253194.pdf 2 40 bibliography 0.9866699 "g Fundação SEADE. Perfil Municipal de Ribeirão Preto. São Paulo; 2012 [cited 2012 Sept 28]. Available from: http://www.seade.gov.br/ produtos/perfil/perfil.php" 5376 5537 W1600253194.pdf 2 41 separator 0.96587753 ¶ 5537 5539 W1600253194.pdf 2 42 bibliography 0.9924786 "h Sistema de Informações de Nascidos Vivos. Nascidos Vivos - Ribeirão Preto (SP). Dados referentes a Nascidos Vivos no Município de Ribeirão Preto. Ribeirão Preto; 2012 [cited 2012 Sept 28]. Available from: http://www.ribeiraopreto.sp.gov.br/ssaude/vigilancia/vigep/tabnet/" 5539 5816 W1600253194.pdf 2 43 separator 0.5305781 5816 5817 W1600253194.pdf 2 44 bibliography 0.8737811 ¶ i16nascidos.php 5817 5834 W1600253194.pdf 2 0 text 0.99925447 "observed in splenocytes, and Ad-CA-gagopt was the most effective at inducing triple producers and double producers, INF- cand CD107a. There appears to be an inconsistence between data of Fig. 3 and Fig. 4. This is thought to be the one by difference of the character of two assays. Tetramer assay measure antigen-specific T cell numbers, whereas multicolor ICS assay measure antigen- specific T cell functions. These assays are not necessarily equivalent [30,31]." 0 477 W1970136038.pdf 6 1 separator 0.9881722 ¶ 477 479 W1970136038.pdf 6 2 text 0.9995295 "To express two antigens in a bicistronic vector, we used three different approaches, IRES-, F2A-dependent or a fusion type. The F2A-dependant second gene showed a greater efficiency of expression in HeLa cells and higher immunogenicity in mice." 479 730 W1970136038.pdf 6 3 separator 0.9788666 ¶ 730 732 W1970136038.pdf 6 4 text 0.99970335 "Difficulties regarding the expression efficiency of the second gene have been reported in the use of IRES elements and fusion type genes. IRES-dependant expression can be significantly lower than cap-dependant expression [16]. On the other hand, F2A- dependant expression was very stable in cell lines and in mice [32]. We speculate that this difference in expression efficiency of the second gene depends on the mode of expression. IRES sequences allow the initiation of translation in a cap-independentway [15] and F2A sequences work as a self-cleavage site in peptides [18,33]. To our knowledge, there are no reports about the comparison of second gene expression dependent on adapter sequences. Probably, this F2A-dependant cleavage occurs more efficiently than internal ribosomal binding in mammalian cells. AsSyzmczak et al. pointed out, the small 2A peptide at the end of the C-terminus of the protein may contribute to the antigenicity of proteins [32]. The F2A sequences used in this study were 2A sequences adjacent to a furin cleavage site; most of the Gag protein had no additional peptide at its C-terminus, and free-2A peptide should exist in mice [17]. However, in rare cases the Gag protein can still have a small peptide at its C-terminus. We investigated the immunogenicity of Gag, the first gene in the bicistronic vector, by the H-2K d/p24 tetramer assay. Significant differences in Gag- specific immunity were not detected between the three types of linkage (data not shown). There is not sufficient information regarding the safety of the F2A peptide in the clinical setting.Further research should be conducted for F2A-dependant bicistronic vectors with the aim of advancing towards clinical trials." 732 2505 W1970136038.pdf 6 5 separator 0.9867991 ¶ 2505 2507 W1970136038.pdf 6 6 text 0.99909186 "Although the efficiency of expression of the fusion protein was the second best in this study, the immunogenicity of Env induced by Ad-GE was approximately the same as Ad-G-IRES-E. Ad-GE expresses the Env protein not only as a single protein but also as a fusion protein (Fig. 6B). Whether processing of this fusion proteinoccurs in the proteasome or whether some TAP-dependent transaction steps take place in the antigen presentation cells has not been established. It is likely that the Gag part of the fusion protein was processed properly since immune responses to Gag were observed using the tetramer assay (data not shown). The" 2507 3157 W1970136038.pdf 6 7 separator 0.9477427 ¶ 3157 3159 W1970136038.pdf 6 8 caption 0.9954829 "Figure 7. HIV clade C Env-specific humoral immune response. HIV clade C Env-specific Ab titer was measured by ELISA. The mice (6/group) were immunized with 1 6108pfu of Ad vector (Ad-G-IRES-E, Ad-GE, or Ad-G-F2A-E). Eight hundred-fold diluted immune sera were used for ELISA. The ELISA plate was coated with HIV clade C Env peptide. The detection of Env-specific Ab titer was performed at an absorbance of 450nm. This assay wasperformed with 6 individual mice sera. Data represent the means 6S.E.M. and are representative of two independent experiments. *, p,0.05; **,p,0.01." 3159 3741 W1970136038.pdf 6 9 separator 0.91433084 ¶ 3741 3743 W1970136038.pdf 6 10 paratext 0.9733339 doi:10.1371/journal.pone.0030302.g007Optimized Ad5/35 HIV Vaccine 3743 3809 W1970136038.pdf 6 11 separator 0.64820313 ¶ 3809 3811 W1970136038.pdf 6 12 paratext 0.9756789 PLoS ONE | www.plosone.org 7 January 2012 | Volume 7 | Issue 1 | e30302 3811 3883 W1970136038.pdf 6 0 paratext 0.9897542 Appl. Sci. 2022 ,12, 7893 12 of 16 0 34 W4290466587.pdf 11 1 separator 0.9919924 ¶ 34 36 W4290466587.pdf 11 2 text 0.99810785 "a balanced tree. Although the BIRCH algorithm is a very efficient algorithm, in terms of search pattern, it obtained patterns close to those of standard clustering algorithms in our study focused on capturing similar job postings." 36 270 W4290466587.pdf 11 3 separator 0.7345066 ¶ 270 272 W4290466587.pdf 11 4 text 0.9967907 "In Tables 4 and 5, the complexity analyses for the five different job groups are detailed, where we selected all features using the FP-Growth algorithm." 272 426 W4290466587.pdf 11 5 separator 0.99643373 ¶ 426 428 W4290466587.pdf 11 6 title 0.958807 Table 4. Complexity tests (time) with feature selection (FP-Growth). 428 497 W4290466587.pdf 11 7 separator 0.9411384 ¶ 497 499 W4290466587.pdf 11 8 table 0.9959315 "Algorithms Acc. (ms) CSE (ms) Mar. (ms) MI (ms) Coo. (ms) DQ 25,122 16,197 9712 5982 496 SOM 7972 4654 4387 2765 287 Kmeans++ 6712 3423 4162 2871 301 BIRCH 1187 1019 879 497 58 S-CF Tree(2) 873 578 492 259 57 S-CF Tree(3) 871 581 501 271 59 S-CF Tree(4) 877 583 498 268 58" 499 786 W4290466587.pdf 11 9 separator 0.98985803 ¶ 786 788 W4290466587.pdf 11 10 title 0.89975244 Table 5. Complexity tests (#hops) with feature selection (FP-Growth). 788 858 W4290466587.pdf 11 11 separator 0.8994266 ¶ 858 860 W4290466587.pdf 11 12 table 0.9960011 "Algorithms Acc. CSE Mar. MI Coo. DQ - - - - - SOM 737 307 278 142 16 Kmeans++ 737 307 278 142 18 BIRCH 29 10 9 8 6 S-CF Tree(2) 20 16 16 16 8 S-CF Tree(3) 21 18 18 18 9 S-CF Tree(4) 20 16 16 16 8" 860 1070 W4290466587.pdf 11 13 separator 0.9868624 ¶ 1070 1072 W4290466587.pdf 11 14 text 0.9996369 "The first outcome of this analysis is that due to the dimensionality reduction operations, noticeable increases in performance were observed for all datasets. As the second outcome, the best performances in terms of both time and number of hops were observed for algorithms using a tree data structure. However, in all versions of the proposed S-CF Tree algorithm, better performances were achieved in terms of time compared to the BIRCH algorithm. Finally, for all datasets, it was found that the variety of the number of clusters in any entity in the S-CF Tree did not have an effect on the hop counts and time." 1072 1697 W4290466587.pdf 11 15 separator 0.9770168 ¶ 1697 1699 W4290466587.pdf 11 16 text 0.99917054 "In Table 6, the complexity analyses performed for five different job groups are de- tailed, again eliminating some features with the FP-Growth algorithm. The analyses were performed by measuring the accuracy according to the SSE values. The accuracy values of DQs were obtained similar to those in Table 3. The values in Table 6 show that the SSE values slightly increased as some significant features had been eliminated by FP-Growth. It can be observed that the SSE values of the S-CF Tree versions increased, which presented the highest accuracy values by between 6% and 7%." 1699 2287 W4290466587.pdf 11 17 separator 0.9964889 ¶ 2287 2289 W4290466587.pdf 11 18 title 0.68633705 Table 6. Accuracy tests without feature selection (FP 2289 2343 W4290466587.pdf 11 19 table 0.5832395 -Growth). 2343 2352 W4290466587.pdf 11 20 separator 0.6423781 ¶ 2352 2354 W4290466587.pdf 11 21 table 0.9961851 "Algorithms Acc. CSE Mar. MI Coo. DQ 12,982 10,079 7129 3609 598 SOM 7235 7001 3862 2198 190 Kmeans++ 7249 6909 3871 2012 187 BIRCH 7148 5991 3810 2911 190 S-CF Tree(2) 3597 2388 3019 2617 187 S-CF Tree(3) 3590 2398 3029 2603 182 S-CF Tree(4) 3599 2487 3022 2612 182" 2354 2634 W4290466587.pdf 11 0 paratext 0.99045795 Cells 2022 ,11, 3459 11 of 18 0 29 W4308120819.pdf 10 1 separator 0.99226546 ¶ 29 31 W4308120819.pdf 10 2 title 0.9910381 3.5. DJK-5 Reduced the Cellular Stress Response to Amino Acid Starvation 31 104 W4308120819.pdf 10 3 separator 0.9951394 ¶ 104 106 W4308120819.pdf 10 4 text 0.9913968 "Host integrated stress response can shape the innate immune response during infec- tions through detection of cellular stresses and damages caused by pathogenic bacteria regardless of their specific virulence factors [ 35]. MRSA biofilm infection increased skin metabolism including rRNA processing ( p= 4.310" 106 421 W4308120819.pdf 10 0 text 0.99628013 "against B41, although the small molecule was not able to neutralize other viruses in the 12 -member global 205 panel (Fig. 4 , A and B ). At high concentration (30 μM) some neutralization against the negative control 206 A-MLV was measured ( Fig. 4C ). Interestingly, the T -20 control also showed some non-specific effects 207 against A -MLV , but this non-specificity was not seen for BMS -626529 ( Fig. 4C ). Due to its measured 208 inhibition and relative specificity towards HIV-1, we next investigate d GO52 further by cryo -EM. 209" 0 555 W3107127464.pdf 9 1 separator 0.82329047 ¶ 210 ¶ 556 566 W3107127464.pdf 9 2 title 0.954982 GO52 binds the trimer base via aromatic interactions with gp41 566 630 W3107127464.pdf 9 3 separator 0.8167081 211 ¶ 631 638 W3107127464.pdf 9 4 text 0.9992223 "During our previous cryo-EM attempts, we noticed that the complexes, particularly the trimers, 212 had a tendency to dissociate over time in the presence of small molecules (Fig. S3F) . Presumably, this 213 destabilization occurs from the presence of the solvent, or even the trapping of an energetically 214 unfavorable state of the FP. To circumvent this, we used glutaraldehyde to crosslink the B41-CD4 -17b 215 complex to stabilize it prior to small molecule addition. Indeed, fewer dissociated protomer particles were 216 seen in the frozen samples , with an estimated 28% of particles resembling dissociated protomers compared 217 to ~60% in the GO35 sample (Fig. S5A). Ultimately, a 3.6 Å cryo-EM reconstruction reveal ed that GO52 218 binds in the predicted pocket, and major interactions involve conserved Y586 and F522, and a rarely 219 occurring (1.5% of sequences) F518 that is found in B41 Env (Fig. 5B, fig. S5B, and table S1). The FP 220 is reconfigured compared to the DDM-bound complex such that the side chain of F518 supplants the F522 221 side chain from the DDM -bound complex. F522 now becomes a secondary contact to GO52 and is trapped 222 between F518 and L537 (of FPPR) (Fig. 5C). F518 forms a cluster of five aromatic rings (F518, F522 and 223 Y586 of gp41, Y40 of gp120, and the methylbiphenyl group of GO52) (Fig. 5B ). 224" 638 2033 W3107127464.pdf 9 5 separator 0.8405866 ¶ 2034 2036 W3107127464.pdf 9 6 text 0.9947648 "The C3-symmetric map suggests dynamic movement of the FP centered on F522 that is not simply 225 a difference in rotamers, so we generated an asymmetric reconstruction of the same dataset (~4.0 Å 226 resolution ) to investigate further (Fig. S5C, and table S1). In all three protomers, the phenyl group of" 2036 2349 W3107127464.pdf 9 7 paratext 0.93270975 227 . CC-BY 4.0 International license available under a(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted June 12, 2020. ; https://doi.org/10.1101/2020.06.11.146654doi: bioRxiv preprint 2349 2690 W3107127464.pdf 9 0 paratext 0.98182386 ACTA ORTOP BRAS 13(4) - 2005 192 0 32 W2014698862.pdf 3 1 title 0.6905755 a 32 33 W2014698862.pdf 3 2 text 0.9985237 "umento da velocidade angular média. Isto vai ao encontro do que foi apresentado na Figura 7b, onde a diferença do torque de resistência ( τ r) para as diferentes velocidades foi pequena. Desta forma, o incremento do τ r devido à variação do componente inercial parece não ter sido suficiente para exigir maiores níveis de exigência muscular. Ao contrário, durante a FP , a dife- rença entre os torques de resistên-cia foi mais acentuada (Fig. 7a). Em virtude dos menores valores de τ tb durante a FP , a variação do componente inercial na quantifica-ção do τ r parece ter sido suficiente para promover um aumento da exigência muscular, durante a extensão de joelho. Ao realizar o teste com V120, houve um aumento significativo do nível de atividade mioelétrica das porções dos músculos VMO, VML, VL e RF em relação ao movimento com velocidade angular de 60o/seg.De maneira similar a outros estudos, ao comparar a intensidade de ativação de cada músculo nas diferentes situações de teste, não foi possível identificar ativação seletiva do VMO (7,9). Estes resultados sugerem que o quadríceps atue como um complexo muscular, no qual a exigência de maior ativação muscular seja distribuída entre todas as suas porções. Matheson et al. (7) encontraram grande interação entre o RF , VL e o VMO em diferentes tipos de exercícios para reforço do quadríceps. Tobin e Robinson (2) afirmam que o VMO possui capacidade ine- rente para atingir os níveis de atividade do VL e esta capacidade encontra-se rompida em indivíduos com SDFP . Grabiner et al. (5) destacam que o VMO não é capaz de contribuir para a extensão do joelho, enquanto que o VL, além de gerar torque para extensão, promove uma tendência de lateralização da patela. Eles ainda identificaram que a eficiência do VL em estender o joelho é diminuída quando a patela encontra-se lateralizada. Concluindo que a função do VMO é, justamente, promover esta-bilização dinâmica medial da patela e otimizar a atividade do VL. Visto que este estudo envolveu indivíduos sadios, os resultados" 33 2110 W2014698862.pdf 3 3 separator 0.9857342 ¶ 2111 2113 W2014698862.pdf 3 4 caption 0.72478944 Fixação oblíqua (FO): linha continua. Fixação paralela (FP): linha tracejada. 2113 2191 W2014698862.pdf 3 5 separator 0.98973304 ¶ 2191 2193 W2014698862.pdf 3 6 caption 0.99613214 "Figura 5 - Torque gerado pelo peso do segmento perna-pé em função do ângulo de flexão do joelho." 2193 2293 W2014698862.pdf 3 7 separator 0.9868608 ¶ 2293 2295 W2014698862.pdf 3 8 text 0.99882144 "desta pesquisa corroboram com as afirmações destes autores. Matheson et al. (7) comentam que na medida em que não foi encontrada uma forma de reforçar isoladamente o VMO, a relação entre o reforço muscular do quadríceps e a diminuição da dor patelar é incerta. No entanto, sugerem ser possível que o reforço muscular do quadríceps, ape-sar de inespecífico, promova ganhos de força em um de-terminado limiar que permita uma estabilização medial suficiente. Grelsamer (15) afirma que o reforço do quadríceps é benéfico para o tratamento da SDFP , desde que o exercício não provoque dor.É possível que a etiologia da SDFP pode ser uma interação entre fatores mecânicos e neuromusculares. Visto que alguns trabalhos indicam a possível existência de alterações do controle neuromuscular do quadríceps em indivíduos com SDFP , a razão para o sucesso da reabilitação destes pacientes pode estar, também, vinculada à reeducação de aspectos neuromotores (3,5)." 2295 3265 W2014698862.pdf 3 9 separator 0.98407465 ¶ 3266 3268 W2014698862.pdf 3 10 text 0.9996126 "Owings e Grabiner(3) sugerem a presença de uma ruptura no controle do quadríceps para contrações excêntricas. Voight e Wie-der (8) destacam que indivíduos com SDFP podem apresentar um desequilíbrio neuromotor que promove um retardo no tempo de ativação reflexa do VMO em relação ao VL. Estes autores afirmam, ainda, que medidas específicas para reeducação do mecanismo extensor do joelho podem reverter este quadro. Alguns autores preconizam que o plano de tratamento de pacientes com SDFP deva considerar aspectos mecânicos e neuromusculares (5,15)." 3268 3829 W2014698862.pdf 3 11 separator 0.9734234 ¶ 3830 3832 W2014698862.pdf 3 12 text 0.9997006 "Outro fator a ser considerado, é a possibilidade das condutas realizadas na reabilitação serem capazes de romper com a inibi-ção reflexa quadricipital, quando esta apresentação clínica estiver presente e, desta forma, obter-se melhora dos sintomas. Grabiner et al. (5) abordam esta questão sugerindo que dada a impossibilidade de reforçar isoladamente o VMO, talvez, o obje-tivo da fisioterapia deva voltar-se para recuperação ou conquista" 3832 4277 W2014698862.pdf 3 13 separator 0.99249953 ¶ 4278 4280 W2014698862.pdf 3 14 caption 0.995376 "Figura 6 - Componente inercial para diferentes velocidades angulares médias.Figura 4 - Torque gerado pelo tubo elástico." 4280 4406 W2014698862.pdf 3 0 text 0.9996568 "dziæ nowe, niemal automatyczne sankcje dla niesubordynowanych pañstw strefy euro. KE bê - dzie od nich ¿1daæ nieoprocentowanego karnego depozytu w wysokoœci 0,2 proc. PKB, który UE odmra¿a3aby po powrocie do w3aœciwej polityki gospodarczej. W przeciwnym wypadkuKE naliczy odsetki, a depozyt przepadnie i stanie siê grzywn1. Sankcje te nak3adane maj1 byæw procedurze „g3osowania odwrotnego” . Oznacza to, ¿e ka¿dorazowo wniosek KE o na3o¿e - nie sankcji bêdzie uznawany za przyjêty, chyba ¿e w ci1gu 10 dni ministrowie finansów UE-27 odrzuc1 go kwalifikowan1 wiêkszoœci1 g3osów. Odsetki od depozytów oraz grzywnyzostan1 rozdzielone pomiêdzy pañstwa strefy euro, do których sytuacji gospodarczo-bud¿eto - wej nie ma ¿adnych zastrze¿eñ. Sankcje stan1 siê naturaln1 konsekwencj1, której mog1 spodziewaæ siê uchybiaj1ce swoim zobowi1zaniom pañstwa cz3onkowskie strefy euro – zapo - wiedzia3a KE." 0 904 W807450044.pdf 19 1 separator 0.99199724 ¶ 904 906 W807450044.pdf 19 2 text 0.999495 "W dyskusjach nad zacieœnieniem dyscypliny Polska opowiedzia3a siê za równym trakto - waniem wszystkich pañstw Unii, aby zapobiec pog3êbianiu podzia3ów na strefê euro i pañ - stwa, które jeszcze nie przyjê3y wspólnej waluty. Ale nowe sankcje obejm1 na razie tylko strefê euro, bowiem prawnicy Komisji doszli do wniosku, ¿e dla ca3ej UE nie da siê ich wpro - wadziæ bez zmian traktatowych." 906 1302 W807450044.pdf 19 3 separator 0.9855225 ¶ 1302 1304 W807450044.pdf 19 4 text 0.9994402 "W celu zwiêkszenia dyscypliny finansowej w ca3ej UE, niemiecki minister finansów Wolfgang Schauble w liœcie z 23 wrzeœnia 2010 roku do swych odpowiedników w UE zaapelo- wa3 o jak najsurowsze i najszersze sankcje, w tym polegaj1ce na zamra¿aniu subwencji unijnych(np. funduszy rolnych i strukturalnych) dla niesubordynowanych pañstw cz3onkowskich. Nieby3o jednak zgody na takie rozwi1zanie ze strony wszystkich ministrów UE-27 w ramach gru-py „task force” pod kierunkiem Przewodnicz1cego Rady Europejskiej Hermana Van Rom-puya, która dyskutowa3a, jak wzmocniæ dyscyplinê bud¿etow1 i zarz1dzanie gospodarczew UE. Chc1c jednak zmusiæ cz3onków strefy euro do trzymania w ryzach wydatków publicz-nych, KE zaproponowa3a now1 zasadê, by roczny wzrost wydatków publicznych nie przekracza3 œredniej stopy wzrostu PKB , chyba ¿e rz1dy znajd1 nowe dochody na pokrycie dodatkowych wydatków. Trzeba zerwaæ z obecn1 w przesz3oœci polityk1 samozadowolenia powszechn1 w czasie dobrej koniunktury. Czêœæ prewencyjna Paktu Stabilnoœci i Wzrostu ma zapewniæ, bypañstwa prowadzi3y rozwa¿n1 politykê bud¿etow1 w czasach dobrej koniunktury, tak aby mócdysponowaæ odpowiednim buforem na czas pogorszenia warunków – argumentowa3a Komi - sja. Dlatego istniej1ca procedura nadmiernego deficytu (powy¿ej 3 proc. PKB) bêdzie groziæ tak¿e za nadmierny d3ug publiczny, przekraczaj1cy 60 proc. PKB. Ponadto KE zapropono - wa3a nowy element unijnych ram nadzoru gospodarczego: procedurê nadmiernego zaburze - nia równowagi gospodarczej. Bêdzie ona obejmowaæ regularnie prowadzon1 ocenê ryzyka zaburzeñ równowagi finansowej, opieraj1c1 siê na zestawie wskaŸników takich jak saldo han - dlowe, koszt si3y roboczej, dynamika cen nieruchomoœci, d3ug publiczny w stosunku do PKB itp. Jeœli KE uzna, ¿e jest ryzyko funkcjonowania unii gospodarczo-walutowej, Rada UE maprzyjmowaæ zalecenia i wszczynaæ procedurê karn1. Cz3onkom strefy eur o i w tym przypadku gro¿1 sankcje: coroczna grzywna w wysokoœci 0,1 proc. PKB ¶" 1304 3310 W807450044.pdf 19 5 paratext 0.8465424 25. 3310 3314 W807450044.pdf 19 6 separator 0.9939949 ¶ 3314 3316 W807450044.pdf 19 7 text 0.99970156 "Na pocz1tku 2011 roku, w wa¿nym, ale i trudnym dla Unii Europejskiej momencie rozwo - jowym pojawi3o siê roczne sprawozdanie gospodarcze, rozpoczynaj1ce pierwszy „europejski okres oceny” . Stwierdzono w nim, ¿e po dwóch trudnych latach ( 2009–2010) zintegrowana Europa powoli, ale jednak podnosi siê z recesji. O¿ywienie gospodarcze nasila siê i nabieratempa, mimo ¿e rynki krajowe oraz sektor finansowy ci1gle jeszcze wymagaj1 skoordynowa" 3316 3762 W807450044.pdf 19 8 paratext 0.9447953 "-78 Maciej WALKOWSKI PP 1 ’12 25Ibidem oraz Ostry kurs polityki bud¿etowej KE , PAP/af, www.forbes.pl." 3762 3867 W807450044.pdf 19 0 paratext 0.92844397 "34 Broderick L, et al." 0 24 W4385987394.pdf 4 1 separator 0.79890656 ¶ 24 26 W4385987394.pdf 4 2 title 0.8116551 JOURNAL OF HEALTH ECONOMICS AND OUTCOMES RESEARCH 26 76 W4385987394.pdf 4 3 separator 0.8207114 ¶ 76 78 W4385987394.pdf 4 4 text 0.99585223 "reported that SLE-associated OD had significantly affected their ability to socialize; one participant stated: “... it’s really impacted me because I’m basically a hermit. I don’t leave my house” [ID 024, female, OD: dermatological, musculo- skeletal, diabetes, premature gonadal failure, pulmonary, renal]." 78 395 W4385987394.pdf 4 5 separator 0.9443884 ¶ 396 398 W4385987394.pdf 4 6 text 0.9996222 "Participants described how stepping back from meaningful social con- nections had led to feelings of isolation and how their need to do so was linked to physical symptoms of OD, risk of infections, sensitivity to sun/extreme temperatures or an inability to make plans because of un- predictable symptoms. SLE-associated OD complicated participants’ family relationships (n = 30; 75%). They spoke of the difficulties they and their families encountered when their physical health deteriorated and their need to rely on others increased, their feelings of being a burden to their families, and changes in their relationship dynamics. As participants may outwardly appear healthy, many of those interviewed felt misunderstood by family and friends who lacked understanding of what it means to live with OD and the debilitating nature of symp- toms, further complicating relationships. Issues of intimacy, including physical intimacy, within relationships were also highlighted by inter- viewees with partners while others were reluctant to pursue a new rela- tionship because of the complications associated with OD." 398 1549 W4385987394.pdf 4 7 title 0.98960555 Table 2. Patient Descriptions of the Impact of SLE-Associated OD 1549 1613 W4385987394.pdf 4 8 separator 0.9747782 ¶ 1613 1615 W4385987394.pdf 4 9 title 0.95701474 T opic Example Patient Quote 1615 1644 W4385987394.pdf 4 10 separator 0.988011 ¶ 1644 1646 W4385987394.pdf 4 11 text 0.97875845 "Physical functioning: Severe fatigue“Fatigue is, is terrible... There are days when you wake up, you’re okay, you’re, you know, you’re doing your thing and then, it just kind of hits you like a... ton of bricks. And, you’re like, that’s it. I’m done. I’m gonna go lay down, and nobody bother me. And that’s just, kind of, how it goes. And you never know when this ton of bricks is gonna hit you.”" 1646 2051 W4385987394.pdf 4 12 separator 0.9759928 ¶ 2051 2053 W4385987394.pdf 4 13 bibliography 0.84220636 — ID 018, female; OD: dermatological, gastrointestinal, musculoskeletal, peripheral vascular, pulmonary 2053 2157 W4385987394.pdf 4 14 separator 0.99256086 ¶ 2157 2159 W4385987394.pdf 4 15 title 0.5489632 Cognitive functioning 2159 2181 W4385987394.pdf 4 16 text 0.99624425 "“... my brain is always super foggy, like, I used to pride myself on being super witty and, you know, being able to have a conversation that would change, you know, topics all the time and I could, I could keep up. I was a great conversationalist. And now, I honestly, I feel like somebody stole half my IQ... I used to be a pharmacy technician... If I gave them the wrong medication, or the wrong dose. Or didn’t check to see if there’s interactions... it is a lot of responsibilities and I loved my job, but it was getting to be... difficult... instead of double-checking every prescription, I was having to, you know, check five, six, seven times. And, I was having to have... my employees, the people that worked for me and under me, check my work for m.e”." 2181 2947 W4385987394.pdf 4 17 separator 0.98457 ¶ 2947 2949 W4385987394.pdf 4 18 bibliography 0.86404866 — ID 015, female; OD: cardiovascular, dermatological, musculoskeletal, ocular, renal 2949 3034 W4385987394.pdf 4 19 separator 0.9940567 ¶ 3034 3036 W4385987394.pdf 4 20 title 0.90566903 Psychosocial functioning: 3036 3062 W4385987394.pdf 4 21 separator 0.9165557 ¶ 3063 3065 W4385987394.pdf 4 22 text 0.99840575 "Emotional“I find myself getting more irritable, I find myself just waking up angry at life, some days I can be the strongest woman in the world and some days I want to stay a fetal position and cry, but I call those my soulless moments and that’s how I defeat that feeling so what? You have lupus, so what, you have organ damage, so what you’re going through these things? Look at the positive things you’ve achieved, you have five degrees, you have beautiful children, you have um... businesses that you have created on your own, you are fierce, you can do it, so I kind of encourage myself. Because at this point in my life, I feel confined, restricted, I feel less than a mother um, a spouse, I feel as if my life is deteriorating before my eyes and nobody can help me.”" 3065 3855 W4385987394.pdf 4 23 separator 0.9831277 ¶ 3855 3857 W4385987394.pdf 4 24 bibliography 0.8924248 "— ID 010, female; OD: cardiovascular, dermatological, gastrointestinal, musculoskeletal, neuropsychiatric, ocular, peripheral vascular, pulmonary, renal" 3857 4013 W4385987394.pdf 4 25 separator 0.99284697 ¶ 4013 4015 W4385987394.pdf 4 26 title 0.9507003 Psychosocial functioning: 4015 4041 W4385987394.pdf 4 27 separator 0.94812226 ¶ 4042 4044 W4385987394.pdf 4 28 text 0.99955523 "Social“... it’s a fatigue in my body to the point where I feel like I can’t do something... it’s past exhaustion... I have never had this before I was diagnosed... I was tired, but I could function. This is sometimes to the point where I don’t feel I can function... I was uh real active in making crafts and doing things you know around my house um, gardening, stuff like that, the fatigue is so bad I don’t feel like I can do that anymore... as far as going out, I used to exercise a lot and I find that I’m... I just feel so tired that when my friends call me and say, ‘hey do you want to go walking?’ I can’t motivate myself to go walking because I just have... it’s like a heaviness and I can’t... I just can’t do it. And I’m afraid to commit to things because I’m afraid I’ll get like halfway through and then I’ll stop.”" 4044 4872 W4385987394.pdf 4 29 separator 0.96710956 ¶ 4872 4874 W4385987394.pdf 4 30 bibliography 0.84600705 — ID 036, female, OD: dermatological, musculoskeletal, ocular, renal 4874 4943 W4385987394.pdf 4 31 separator 0.99404037 ¶ 4943 4945 W4385987394.pdf 4 32 title 0.96393454 Psychosocial functioning: 4945 4971 W4385987394.pdf 4 33 separator 0.88802123 ¶ 4972 4974 W4385987394.pdf 4 34 title 0.5528876 4974 4975 W4385987394.pdf 4 35 text 0.9966389 "Relationships“[My previous partner] was trying to push me more saying oh come on, you can go, go, go and then when he... saw that I physically had to sit down and I couldn’t do things, it changed the dynamics of our relationship... it’s changed our roles because he feels like he has to be a caregiver instead of my equal... and with my son um you know, we used to go to movies all the time um I, at one time was in law enforcement and he is now in law enforcement and we used to go to the range, you know and, and keep up our, our skills and I can’t do that anymore... So, it’s changed that dynamic as well.”" 4975 5591 W4385987394.pdf 4 36 separator 0.95035887 ¶ 5591 5593 W4385987394.pdf 4 37 bibliography 0.767374 — ID 009, female; OD: musculoskeletal, renal 5593 5638 W4385987394.pdf 4 38 separator 0.99485534 ¶ 5638 5640 W4385987394.pdf 4 39 title 0.94724375 "Economic and work- related well-being" 5640 5680 W4385987394.pdf 4 40 text 0.99791676 "“I did manage to keep working, you know, up until about 2010 and I just couldn’t do it anymore. I just couldn’t... And, you know, fortunately I managed to get my disability, a lot of people aren’t able to do it and you know, it’s... it’s difficult but um, I got it and then that was a huge lifestyle change again for me... I’m in uh public housing so... there’s no way that I could be able to live on my own, you know, out in the real world because it’s too expensive... I don’t know what I would do. You know, I get a whole whopping $16 in food stamps... that at times can be an issue because you know, you only have so much money to spend and then it’s gone so...um...you know, it can be an issue sometimes.”" 5680 6392 W4385987394.pdf 4 41 separator 0.89224523 ¶ 6392 6394 W4385987394.pdf 4 42 bibliography 0.8710263 — ID 033, female; OD: gastrointestinal, peripheral vascular, pulmonary 6394 6465 W4385987394.pdf 4 43 separator 0.99353206 ¶ 6465 6467 W4385987394.pdf 4 44 title 0.93791604 "Overall impact of SLE- associated OD compared with SLE without OD“" 6467 6539 W4385987394.pdf 4 45 text 0.99940145 "It wasn’t that much of an issue before the organs were involved, um, but I say that looking back, I mean at the time I felt terrible, but now that I... once I developed the organ damage I look back, I’m like oh I wish I could go back to then.”" 6539 6786 W4385987394.pdf 4 46 separator 0.8633249 ¶ 6786 6788 W4385987394.pdf 4 47 bibliography 0.8232472 — ID 041, female; OD: dermatological, musculoskeletal 6788 6842 W4385987394.pdf 4 48 separator 0.9945232 ¶ 6842 6844 W4385987394.pdf 4 49 bibliography 0.46785322 Abbreviations: OD, 6844 6863 W4385987394.pdf 4 50 text 0.4380221 organ 6863 6869 W4385987394.pdf 4 51 bibliography 0.46846965 6869 6870 W4385987394.pdf 4 52 text 0.44873887 damage 6870 6876 W4385987394.pdf 4 53 bibliography 0.42843303 ; 6876 6877 W4385987394.pdf 4 54 text 0.61483395 SLE, systemic lupus erythematosus. 6877 6912 W4385987394.pdf 4 0 paratext 0.8438256 Jiang et al. /one.tnum/zero.tnum./three.tnum/three.tnum/eight.tnum/nine.tnum/fneur./two.tnum/zero.tnum/two.tnum/two.tnum./one.tnum/one.tnum/one.tnum/two.tnum/six.tnum/two.tnum/four.tnum 0 185 W4313556442.pdf 2 1 separator 0.9930832 ¶ 185 187 W4313556442.pdf 2 2 title 0.9809623 Publisher’s note 187 204 W4313556442.pdf 2 3 separator 0.9926543 ¶ 204 206 W4313556442.pdf 2 4 text 0.97712255 "All claims expressed in this article are solely those of the authorsanddonotnecessarilyrepresentthoseoftheiraffiliatedorganizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed orendorsedbythepublisher." 206 545 W4313556442.pdf 2 5 separator 0.99701524 ¶ 545 547 W4313556442.pdf 2 6 title 0.92285144 References 547 558 W4313556442.pdf 2 7 separator 0.99458385 ¶ 558 560 W4313556442.pdf 2 8 bibliography 0.99292296 "1. Shi Z, Miao C, Schoepf UJ, Savage RH, Dargis DM, Pan C, et al. A clinically applicable deep-learning model for detecting intracrani al aneurysmin computed tomography angiography images. Nat Commun . (2020) 11:6090.doi:10.1038/s41467-020-19527-w" 560 812 W4313556442.pdf 2 9 separator 0.9203409 ¶ 812 814 W4313556442.pdf 2 10 bibliography 0.5252325 814 815 W4313556442.pdf 2 11 paratext 0.5231471 Frontiersin Neurology 815 836 W4313556442.pdf 2 12 bibliography 0.55202955 836 837 W4313556442.pdf 2 13 paratext 0.526126 /zero.tnum/three.tnum 837 858 W4313556442.pdf 2 14 bibliography 0.47711536 858 859 W4313556442.pdf 2 15 paratext 0.56500757 frontiersin.org 859 874 W4313556442.pdf 2 0 paratext 0.8104483 Serum Myeloperoxidase and Asthma Severity 0 41 W4283268249.pdf 7 1 separator 0.58076316 ¶ 43 48 W4283268249.pdf 7 2 paratext 0.9462701 ¶ Rep. Biochem. Mol. Biol, Vol. 11, No. 1, Apr 2022 189 48 111 W4283268249.pdf 7 3 bibliography 0.9976341 "31. Boxall C, Holgate ST, DE Davies . 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Zhonghua Nei Ke Za Zhi . 1991;30(4):219 -21." 685 818 W4283268249.pdf 7 10 separator 0.97162867 ¶ 819 821 W4283268249.pdf 7 11 bibliography 0.99790484 "35. Scher H, Berman D, Weinberg E G, Schinkel M, Peper B, Chalton DO, et al. Granulocyte proteins in serum in childhood asthma: relation to spirometry and therapy. Clin Exp Allergy . 1996;26(10):1131 -41." 821 1039 W4283268249.pdf 7 12 separator 0.97190756 ¶ 1040 1042 W4283268249.pdf 7 13 bibliography 0.99771667 "36. Raisan, SJ, Sadeq, MH. Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) effecting on asthma patients in Basra Province, Iraq. Biomedical Research -tokyo. 2018;29 (17):3395 -97." 1042 1240 W4283268249.pdf 7 14 separator 0.9798087 ¶ 1241 1243 W4283268249.pdf 7 15 bibliography 0.99796313 "37. Lacoste JY, Bousquet J, Chanez P, Van Vyve T, Simony -Lafontaine J, Lequeu N, et al. Eosinophilic and neutrophilic inflammation in asthma, chronic bronchiti s, and chronic obstructiv e pulmona ry disease. J Allergy Clin Immunol . 1993;92(4):537 -48." 1243 1507 W4283268249.pdf 7 16 separator 0.9764025 ¶ 1508 1510 W4283268249.pdf 7 17 bibliography 0.9975348 "38. Carlson, M, Håkansson L, Kämpe M, Stålenheim G, Peterson C, Venge P, et al. Degranulation of eosinophils from pollen -atopic patients with asthma is increased during pollen season. J Allergy Clin Immunol . 1992;89(1 Pt 1):131 -9." 1510 1759 W4283268249.pdf 7 18 separator 0.96557844 ¶ 1760 1762 W4283268249.pdf 7 19 bibliography 0.99801636 "39. Pelaia, G., et al., Respiratory infections and asthma. Respiratory Medicine . 2006;100(5):775 -784." 1762 1869 W4283268249.pdf 7 20 separator 0.9631976 ¶ 1870 1872 W4283268249.pdf 7 21 bibliography 0.99777555 "40. Yung JA, Fuseini H, Newcomb DC. Hormones, sex, and asthma. Ann Allergy Asthma Immunol . 2018;120(5):488 -494." 1872 1994 W4283268249.pdf 7 22 separator 0.96931195 ¶ 1995 1997 W4283268249.pdf 7 23 bibliography 0.99774134 "41. Naeem A , Silveyra P. Sex Differences in Paediatric and Adult Asthma. Eur Med J (Chelmsf). 2019;4(2):27 -35." 1997 2118 W4283268249.pdf 7 24 separator 0.9738699 ¶ 2119 2121 W4283268249.pdf 7 25 bibliography 0.99752444 "42. Lan Tien Nguyen, Lim S, Oates T, Fan Chung K. Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma. Respir Med. 2005;99(2):200-7." 2121 2310 W4283268249.pdf 7 26 separator 0.9738573 ¶ 2311 2313 W4283268249.pdf 7 27 bibliography 0.9976698 "43. Monteseirín J, Bonilla I, Camacho J, Conde J, Sobrino F. Elevated secretion of myeloperoxidase by neutrophi ls from asthmatic patients: The effect of immunotherapy. J Allergy Clin Immunol. 2001;107(4):623-6." 2313 2538 W4283268249.pdf 7 28 separator 0.9732195 ¶ 2539 2541 W4283268249.pdf 7 29 bibliography 0.997878 "44. Reid DW, Ward C, Wang N, Zheng L, Bish R, Orsida B, Walters et E H. Possible anti - inflammatory effect of salmeterol against interleukin -8 and neutrophil activation in asthma in vivo. 2003 ;21(6): 994-9." 2541 2762 W4283268249.pdf 7 30 separator 0.9911796 ¶ 2763 2765 W4283268249.pdf 7 0 paratext 0.98928577 Page 17/17 0 10 W4378175656.pdf 16 1 separator 0.995546 ¶ 10 12 W4378175656.pdf 16 2 caption 0.75072616 Figure 7 12 21 W4378175656.pdf 16 3 separator 0.994156 ¶ 21 23 W4378175656.pdf 16 4 caption 0.89159495 The DCA curve. 23 38 W4378175656.pdf 16 0 text 0.9986418 "32°N. From this bend, the simulated trajectory runs along the 101°meridian. This trajectory ends at 43°N, the latitude of our 305 northernmost site. This trajectory passes over the middle of the present-day exposure of the Ogallala Formation and, hence, captures a representation of the atmospheric processes that result in δ18Opover the Great Plains." 0 355 W4390562268.pdf 11 1 separator 0.98244095 ¶ 355 357 W4390562268.pdf 11 2 text 0.9987816 "To test for the influence of westerly moisture in the Great Plains (as indicated by the HYSPLIT results), we initialized the vapor transport model with annual mean NARR data interpolated to a simplified 1-D trajectory representing the Westerlies (Figure 8). The trajectory latitude is chosen to lie in between the northern and southern boundary of the Ogallala Formation." 357 733 W4390562268.pdf 11 3 paratext 0.5344095 310 733 737 W4390562268.pdf 11 4 separator 0.99050045 ¶ 737 739 W4390562268.pdf 11 5 text 0.9988962 "To account for the known effects of orographic rainout on westerly moisture (Lechler and Galewsky, 2013; Mix et al., 2019; Friedman et al., 2002), we use a simplified topography, based on the modern observed topographic profile, that follows a Gaussian shaped mountain with a flat plateau in the lee." 739 1044 W4390562268.pdf 11 6 separator 0.99695075 ¶ 1044 1046 W4390562268.pdf 11 7 title 0.9874468 5 Results 1046 1056 W4390562268.pdf 11 8 separator 0.9923325 ¶ 1056 1058 W4390562268.pdf 11 9 title 0.9756147 5.1 Moisture sources and precipitation trajectories 315 1058 1114 W4390562268.pdf 11 10 separator 0.99586 ¶ 1114 1116 W4390562268.pdf 11 11 text 0.9982621 "Contour plots in Figures 3a-d show the percentage of trajectories that produce precipitation at 1000 m above ground level for each of the plotted locations throughout the year. Western sites receive a substantial portion of their moisture from westerly or southwesterly trajectories that traverse the high topography of the North American Cordillera. In particular, the northwestern- most site (Figure 3a), receives little moisture from the Gulf. In contrast, the southeastern-most site (Figure 3d) receives pre- dominantly Gulf moisture.These patterns vary somewhat seasonally, with Gulf/southeasterly moisture more dominant in the 320 spring and summer months and westerly moisture more dominant in the winter months. To better visualize how the contribu- tion of Gulf or southeasterly moisture varies with latitude and longitude, we use HYSPLIT’s clustering algorithm to calculate the fraction of storms that are sourced from the Gulf or southeast. Northern locations receive less gulf/southeasterly moisture than southern locations; however, regardless of latitude, the percentage of storms sourced from the Gulf increases to the east (Figure 3e)." 1116 2286 W4390562268.pdf 11 12 paratext 0.89552164 325 2286 2290 W4390562268.pdf 11 13 separator 0.76535594 ¶ 2290 2292 W4390562268.pdf 11 14 paratext 0.96586645 "12https://doi.org/10.5194/egusphere-2023-2075 Preprint. Discussion started: 28 September 2023 c Author(s) 2023. CC BY 4.0 License." 2292 2427 W4390562268.pdf 11 15 separator 0.9959368 ¶ 2427 2429 W4390562268.pdf 11 0 caption 0.9924917 Figure2The…gureofthesolutionfor u(x;t)obtainedin 0 48 W3153256719.pdf 6 1 separator 0.9940231 ¶ 48 50 W3153256719.pdf 6 2 text 0.41411906 Eq 50 53 W3153256719.pdf 6 3 caption 0.30872586 : 53 54 W3153256719.pdf 6 4 text 0.34910026 (13) 54 58 W3153256719.pdf 6 5 math 0.5982878 whenC1=3;b0=1;b1=2;v=4;=0:9;c=1: 58 91 W3153256719.pdf 6 6 separator 0.9916575 ¶ 91 93 W3153256719.pdf 6 7 text 0.41180918 Case 93 98 W3153256719.pdf 6 8 title 0.47695342 3: 98 101 W3153256719.pdf 6 9 separator 0.98565817 ¶ 101 103 W3153256719.pdf 6 10 text 0.5442442 a0= 103 107 W3153256719.pdf 6 0 paratext 0.9895607 Sustainability 2016 ,8, 506 4 of 12 0 35 W2407196742.pdf 3 1 separator 0.9941174 ¶ 35 37 W2407196742.pdf 3 2 text 0.3855735 TC 37 40 W2407196742.pdf 3 3 table 0.36407298 1°r 40 44 W2407196742.pdf 3 4 text 0.33717588 Qi 44 46 W2407196742.pdf 3 5 table 0.3704556 ptotal final 46 57 W2407196742.pdf 3 6 text 0.41310212 57 58 W2407196742.pdf 3 7 table 0.4402245 consumption 58 69 W2407196742.pdf 3 0 paratext 0.84321225 17 Kr 0 5 W4246916821.pdf 16 1 bibliography 0.6066633 eps, 5 10 W4246916821.pdf 16 2 paratext 0.64372295 i 10 11 W4246916821.pdf 16 3 bibliography 0.64701676 G. 11 13 W4246916821.pdf 16 4 paratext 0.7122008 i 13 15 W4246916821.pdf 16 5 bibliography 0.7711115 L. 15 17 W4246916821.pdf 16 6 paratext 0.5511081 i 17 19 W4246916821.pdf 16 7 bibliography 0.93965703 (1990) iOrganizational iCommunication i(2nd ied.). i(White iPlains, iNew iYork: i i Addison-Wesley iPublishing iCo., iInc.) 19 143 W4246916821.pdf 16 8 separator 0.5030532 i 143 144 W4246916821.pdf 16 9 bibliography 0.9926011 "Mallinckrodt, iB., i& iLeong, iF. iT. i(1992). iSocial isupport iin iacademic iprograms iand ifamily i i environments: iSex idifferences iand irole iconflicts ifor igraduate istudents. iJournal iof i i Counseling i& iDevelopment, i70, i716-723. i Marrone, iS. iR. i(2005). iAttitudes, isubjective inorms, iand iperceived ibehavioural icontrol: iCritical i icare inurses’ iintentions ito iprovide iculturally icongruent icare ito iArab iMuslims. i(Ph.D. i Thesis). iColumbia iUniversity, iUSA. i Martin, iJ. iN., iand iThomas iK. iNakayama, iIntercultural iCommunication iin iContexts, i i 5th ied. i(Boston, iMA: iMcGraw-Hill, i2010), i465. i Neuliep, iJ. iW. i(2012). iThe irelationship iamong iintercultural icommunication i iapprehension, iethnocentrism, iuncertainty ireduction, iand icommunication isatisfaction iduring iinitial iintercultural iinteraction: iAn iextension iof ianxiety iand iuncertainty imanagement i(AUM) itheory. iJournal iof iIntercultural iCommunication iResearch, i41, i1–16. idoi:10.1080/17475759.2011.623239 i[Taylor i& iFrancis iOnline], i[Google iScholar] i Ni, iL., i& iWang, iQ. i(2011). iAnxiety iand iuncertainty imanagement iin ian iintercultural isetting: i iThe iimpact ion iorganization-public irelationships. iJournal iof iPublic iRelations, i23(3), i i 269–301. i Oberg, iK. i(1960) iCulture ishock: iadjustment ito inew icultural ienvironments. iPractical i i Anthropology, i7: i177-82. i Penbek, iS., iYurdakul, iD., i& iCerit, iA. iG. i(July, i2009). iIntercultural icommunication icompetence: i i A istudy iabout ithe iintercultural isensitivity iof iuniversity istudents ibased ion itheir i i i ieducation iand iinternational iexperiences. iPaper ipresented iat ithe iEuropean i i and iMediterranean iConference ion iInformation iSystems i2009, iIzmir. i Rizvi, iFazal iand iLingard, iBob. i2010. iGlobalizing ieducation ipolicy. iLondon, iUK: iRoutledge. i Ruben, iB. i(1976). iAssessing icommunication icompetency ifor iintercultural iadaptation. i i i Groups iand iOrganization iStudies, i1, i334-354." 144 2200 W4246916821.pdf 16 10 separator 0.7936729 i 2200 2202 W4246916821.pdf 16 0 paratext 0.9687134 "Journal of Law, Policy and Globalization www.iiste.org ISSN 2224-3240 (Paper) ISSN 2224-3259 (Online) Vol.119, 2022 ¶ 50" 0 271 W4226051666.pdf 0 1 separator 0.83633965 ¶ 272 274 W4226051666.pdf 0 2 title 0.9868763 "Globalization and the Sovereignty of African States in the Post-Colonial Era: A Contemporary Afrocentric Legal Perspective" 274 403 W4226051666.pdf 0 3 separator 0.9731611 ¶ ¶ 404 410 W4226051666.pdf 0 4 contact 0.99425006 "Michael U. Ukponu Melbourne Research Scholar, Melbourne Law School, T he University of Melbourne 185 Pelham St, Carlton VIC 3053, Australia Email: mukponu@student.unimelb.edu.au (correspondin g author) ¶ Sophia U. Okaruefe Senior Associate, The Law Partners (Barristers & So licitors) 10 Lachlan Close, Maitama, Abuja 900271, Nigeria Email: sophia_okaruefe@yahoo.co.uk ¶ Yusuf Sulayman School of Law, University of Portsmouth Richmond Building, Portland St, Portsmouth PO1 3DE, United Kingdom Email: yusuf.sulayman@port.ac.uk ¶ Janet E. Afonne Barrister and Solicitor of the Supreme Court of Nig eria, Port Harcourt, Nigeria Email: janetafonne@gmail.com ¶ Nathaniel S. Odusola Johnson Shoyama Graduate School of Public Policy, U niversity of Saskatchewan, Saskatoon, SK, Canada Email: nso561@usask.ca" 410 1271 W4226051666.pdf 0 5 separator 0.9794647 ¶ ¶ 1272 1278 W4226051666.pdf 0 6 title 0.9377089 Abstract 1278 1287 W4226051666.pdf 0 7 separator 0.99421936 ¶ 1288 1290 W4226051666.pdf 0 8 text 0.99648917 "Globalization eases human interactions by integrati ng national systems into one international uniform system. Whereas globalization has proven to be more benefic ial for advanced and wealthier countries, poorer an d developing economies, including African countries, often get the short end of the stick albeit accompa nied with short-term benefits. Major international decisions geared towards fostering a globalized order are oft en reached and implemented without significant participation a nd input of African nations, with lasting impacts o n their respective political and socio-economic sovereignti es. Against this backdrop, this article offers an a dvisory to African policymakers and peoples that African state s tread with caution while engaging on the global s tage so that the benefits accruing from a globalized order are not a bait to perpetuate Africa’s accumulated underdevelopment. The article advocates a path towa rds rediscovery and recovery for African sovereignt y." 1290 2305 W4226051666.pdf 0 9 separator 0.58140373 ¶ 2306 2308 W4226051666.pdf 0 10 text 0.9976634 "African states should overhaul their international engagement strategies in order to have their voices heard, add value, and preserve their pride of place in global affairs." 2308 2486 W4226051666.pdf 0 11 separator 0.97453105 ¶ 2487 2489 W4226051666.pdf 0 12 text 0.7325159 Keywords: Globalization, State sovereignty, Neo-liberalism, N eo-colonialism, Africa. 2489 2575 W4226051666.pdf 0 13 separator 0.9809886 ¶ 2578 2580 W4226051666.pdf 0 14 text 0.9446062 "This research did not receive any specific grant fr om funding agencies in the public, commercial, or n ot-for- profit sectors. The authors declare no conflict of interest." 2580 2755 W4226051666.pdf 0 15 separator 0.9298681 ¶ 2756 2758 W4226051666.pdf 0 16 paratext 0.9330173 "DOI: 10.7176/JLPG/119-05 Publication date: March 31 st 2022" 2758 2823 W4226051666.pdf 0 17 separator 0.96089715 ¶ ¶ 2824 2830 W4226051666.pdf 0 18 title 0.9871429 1. Introduction 2830 2847 W4226051666.pdf 0 19 separator 0.99507713 ¶ 2848 2850 W4226051666.pdf 0 20 text 0.9996384 "The description of the world as a Global Village (McLuhan 1996, [1] ; McLuhan 1962, 31 ) probably has its fons et origo in the phenomenon popularly termed Globalization, w hich slowly but steadily manifested from the 18 th century to current global realities ( Heshmati 2004, 2 ). Then, the phenomenon was used to describe the vi llage- like effect that mass media holds in the public spa ce ( McLuhan 1962, 21 and 31 ). There is hardly any gainsaying that globalization has now permeated virtually ever y aspect of human existence and interaction, from p olitics and public administration ( Srivastava 2009, 2 ) to transnational trade and financing, and culture and lifestyle (Heshmati 2004, 15 ; Upadhyay 2014 ), the positive and negative consequences thereof a ll intertwined and interrelated. Presently, globalization has borne it s proboscis of influence into law, justice administ ration, and legal practice ( Romero 2005 ). In the light of these experiences, globalization is a salient phenomenon that continues to influence events at both national and international arenas, thereby cementing the Global Village." 2850 4000 W4226051666.pdf 0 21 separator 0.93213874 ¶ 4002 4004 W4226051666.pdf 0 22 text 0.99964905 "Globalization means different things depending on w ho is performing the analysis. It has generated int erests and divisions amongst political and socio-economic scholars and commentators ( Adangor 2016, 7 ). It is perceived either as an elixir to the underdevelopme nt of the Third World or a tool of neo-colonialism by the" 4004 4335 W4226051666.pdf 0 0 text 0.9995801 "JHEP01(2020)179to NSSI. Additionally, to remove the dependence on the distance of the supernova from the detector (which aects the absolute neutrino ux), and minimize the eect of systematic errors, one can take ratios of events in dierent interaction channels or in dierent time bins." 0 293 W2954209455.pdf 11 1 separator 0.9920366 ¶ 293 295 W2954209455.pdf 11 2 text 0.9997175 "In the standard Hyper-K setup with only water, it is dicult to distinguish between IBD and ES interactions on an event by event basis. This is because electrons and positrons are indistinguishable in a water cherenkov detector, but two solutions are possible. ES and IBD events may be separated on a statistical basis by the angular distributions of the produced (anti-)lepton, as electrons from ES will be approximately forward going and positrons produced from IBD will be essentially isotropic. The second option is neutron tagging which the EGADS collaboration is currently investigating by doping water with Gadolinium [ 28]. If Gadolinium (Gd) is added to the water in Hyper-K then IBD inter- actions are identi able via the resultant neutron capture. Gadolinium has a substantial thermal neutron capture cross section of 49,000 barns and emits an 8 MeV gamma cascade which can be detected via its cherenkov light. At a concentration of 0.1{0.2% the eciency for neutron capture is roughly 90%." 295 1319 W2954209455.pdf 11 3 separator 0.9720371 ¶ 1319 1321 W2954209455.pdf 11 4 text 0.9994804 "A combination of statistical, cut based methods as well as the addition of gadolinium could allow for IBD identi cation with an eciency between 90" 1321 1471 W2954209455.pdf 11 0 paratext 0.8309091 "Premier Jaros3aw Kaczyñski z3o¿y3 30.10.06 jednodniow1 wizytê robocz1 w RFN , http://www.pol-niem.pl/index.php?page=1010600000, 3.11.2006." 0 140 W760967920.pdf 30 1 separator 0.99628246 ¶ 140 142 W760967920.pdf 30 2 title 0.97819144 Regierungserklärung von Bundeskanzlerin Dr. Angela Merkel vor dem Deutschen 142 218 W760967920.pdf 30 3 separator 0.97511435 ¶ 218 220 W760967920.pdf 30 4 bibliography 0.44163844 Bundestag am 30. November 2005 in 220 254 W760967920.pdf 30 5 text 0.49917722 Berlin 254 261 W760967920.pdf 30 6 bibliography 0.61761826 ", „Bulletin der Bundesregierung”nr 93-1 z 30.11.2005, http://www.bundesregierung.de/nn_1514/Con - tent/DE/Bulletin/2001__2005/2005/11/2005-11-30-regierungserklaer ung- -von-bundeskanzlerin-dr-angela-merkel-vor-dem-deutschen- bundestag-.html, " 261 507 W760967920.pdf 30 7 separator 0.36191133 ¶ 507 508 W760967920.pdf 30 8 bibliography 0.58670914 1.03.2006. 508 519 W760967920.pdf 30 9 separator 0.9933736 ¶ 519 521 W760967920.pdf 30 10 title 0.48354805 Spotkanie Ministra Spraw Zagranicznych 521 560 W760967920.pdf 30 11 contact 0.5236634 RP Pana Stefana Mellera z Ministrem 560 596 W760967920.pdf 30 12 separator 0.41407225 ¶ 596 598 W760967920.pdf 30 13 contact 0.6043114 Spraw Zagranicznych RFN Panem Frankiem-Walterem Steinmeierem 598 659 W760967920.pdf 30 14 bibliography 0.57346094 , 659 661 W760967920.pdf 30 15 separator 0.68752015 ¶ 661 663 W760967920.pdf 30 16 bibliography 0.8329489 http://www.pol-niem.pl/index.php?page=1010600000, 15.12.2005. 663 725 W760967920.pdf 30 17 separator 0.99689144 ¶ 725 727 W760967920.pdf 30 18 title 0.69775957 Publicystyka: 727 741 W760967920.pdf 30 19 separator 0.987501 ¶ 741 743 W760967920.pdf 30 20 bibliography 0.47305825 „Der Tagesspiegel” 2006; 743 768 W760967920.pdf 30 21 text 0.4210773 „ 768 770 W760967920.pdf 30 22 bibliography 0.48383588 Der Spiegel” 2006; 770 788 W760967920.pdf 30 23 text 0.4102056 „ 788 790 W760967920.pdf 30 24 bibliography 0.44233853 Die 790 793 W760967920.pdf 30 25 text 0.39936635 Berlin 793 800 W760967920.pdf 30 26 bibliography 0.46150866 er Zeitung” 2007; 800 817 W760967920.pdf 30 27 text 0.42264053 „ 817 819 W760967920.pdf 30 28 bibliography 0.41286543 Die 819 822 W760967920.pdf 30 29 text 0.3962822 Ta 822 825 W760967920.pdf 30 30 bibliography 0.44866005 - ¶ 825 829 W760967920.pdf 30 31 text 0.4245032 geszeitung 829 840 W760967920.pdf 30 32 bibliography 0.417788 ” 2006; 840 847 W760967920.pdf 30 33 text 0.37681997 „ 847 849 W760967920.pdf 30 34 bibliography 0.39114815 Die 849 852 W760967920.pdf 30 35 text 0.36373156 Welt” 852 858 W760967920.pdf 30 36 bibliography 0.40102497 2006, 2008 858 869 W760967920.pdf 30 37 text 0.40768653 ; „Die Zeit” 869 881 W760967920.pdf 30 38 bibliography 0.3568964 2006 881 886 W760967920.pdf 30 39 text 0.3711099 –2007; „Dziennik” ¶ 886 905 W760967920.pdf 30 40 bibliography 0.5125548 2008 905 910 W760967920.pdf 30 41 text 0.4234787 ; „F 910 914 W760967920.pdf 30 42 bibliography 0.37786648 akt 914 917 W760967920.pdf 30 43 text 0.44811222 ” 917 918 W760967920.pdf 30 44 bibliography 0.5129634 2008 918 923 W760967920.pdf 30 45 text 0.3610804 ; „ 923 926 W760967920.pdf 30 46 bibliography 0.32674366 Frankfurt 926 935 W760967920.pdf 30 47 text 0.3591325 er Allgemeine 935 948 W760967920.pdf 30 48 bibliography 0.3731034 Zeitung 948 956 W760967920.pdf 30 49 text 0.34636867 ” 956 957 W760967920.pdf 30 50 bibliography 0.35712194 2006 957 962 W760967920.pdf 30 51 table 0.3495595 – 962 963 W760967920.pdf 30 52 bibliography 0.3492638 2007 963 967 W760967920.pdf 30 53 table 0.32112104 ; „ 967 970 W760967920.pdf 30 54 bibliography 0.32073754 Frank 970 975 W760967920.pdf 30 55 text 0.33561102 fur-ter 975 982 W760967920.pdf 30 56 bibliography 0.34987658 Rundschau” 2007; „Gazeta 982 1007 W760967920.pdf 30 57 text 0.3207468 .pl” 1007 1011 W760967920.pdf 30 58 bibliography 0.3496565 2006; „Gazeta Wy 1011 1028 W760967920.pdf 30 59 text 0.34441975 borcza” 1028 1035 W760967920.pdf 30 60 bibliography 0.35495457 2005 1035 1040 W760967920.pdf 30 61 text 0.30500698 – 1040 1041 W760967920.pdf 30 62 bibliography 0.34691083 2009 1041 1045 W760967920.pdf 30 63 table 0.34322292 ; 1045 1046 W760967920.pdf 30 64 bibliography 0.37900996 „Now 1046 1050 W760967920.pdf 30 65 text 0.3827459 y Dzieñ 1050 1057 W760967920.pdf 30 66 bibliography 0.44380635 ” 2005; „PAP” 2005–2009; „Polityka” 2006; „Puls Biznesu”2006; „Rzeczpospolita” 2005–2009; „Süddeutsche Zeitung” 2007. 1057 1174 W760967920.pdf 30 67 separator 0.99624777 ¶ 1174 1176 W760967920.pdf 30 68 title 0.98658174 Summary 1176 1184 W760967920.pdf 30 69 separator 0.9961302 ¶ 1184 1186 W760967920.pdf 30 70 text 0.99836636 "The paper analyzes the impact of the Nord Stream pipeline construction on Pol- ish-German relations from 2005 to 2009. The author notes that the difficulties in reach-ing a consensus were further increased by the different attitudes of both governmentsto this investment as well as to the cooperation with Russia. From the beginning, Chan - cellor Gerhard Schröder was an advocate of the pipeline construction and a great pro - moter of German-Russian friendship, an attitude to a somewhat lesser degree also continued by his successor – Angela Merkel. Polish President Lech Kaczyñski wasconsistently against the pipeline, supported by subsequent Prime Ministers of Poland.The Polish side was also against the tightened relations between Germany and the Eu - ropean Union and Russia that were supposed to ensure energy security." 1186 2025 W760967920.pdf 30 71 separator 0.9437628 ¶ 2025 2027 W760967920.pdf 30 72 text 0.99912536 "German visits and words of assurance, that were so numerous in the period 2004–2009, were intended to appease Warsaw but they did not mark a change of pol - icy. Although the German government was trying to persuade Poland to support the project, Poland was consistent in its refusal to take part in it. Poland’s persistent stand - point has not changed the German attitude in this matter, while the extremely different approaches of both governments have adversely affected Polish-German relations. Itwas only after the Polish side ceased its continuous criticism of the pipeline project inlate 2008 that a clear détente was apparent." 2027 2673 W760967920.pdf 30 73 paratext 0.77874625 SP 4 ’10 Stosunki polsko- 2673 2698 W760967920.pdf 30 74 title 0.49130428 niemiecki 2698 2707 W760967920.pdf 30 75 paratext 0.51262736 e 2707 2708 W760967920.pdf 30 76 title 0.4981728 na 2708 2711 W760967920.pdf 30 77 paratext 0.49264306 2711 2712 W760967920.pdf 30 78 title 0.51486444 tle 2712 2715 W760967920.pdf 30 79 paratext 0.73798704 budowy Gazoci1gu... 149 2715 2739 W760967920.pdf 30 0 paratext 0.9603331 BJR Case Rep;9:20230048BJR |case reports Case 0 45 W4386715379.pdf 3 1 title 0.78669983 Report: Common carotid artery dissection from sportive choking 45 108 W4386715379.pdf 3 2 paratext 0.93547964 4 of 5 birpublications.org/bjrcr 108 140 W4386715379.pdf 3 3 text 0.99690825 "There are two postulated mechanisms of cerebral ischaemia in the setting of dissection. These are artery- to- artery embolism of intraluminal thrombus aggregating around the intimal dissection flap and haemodynamic compromise resulting from progressive flow- limiting stenosis as blood from the damaged vasa vasorum leaks into the connective tissues between the tunica intima and tunica media.3" 140 552 W4386715379.pdf 3 4 separator 0.9611866 ¶ 552 554 W4386715379.pdf 3 5 text 0.99918234 "The above mechanisms explain why there is often a delay between the inciting traumatic event and the onset of ischaemic symp- toms. In these patients, stroke tends to happen in the first couple of days but may even occur up to 1 month after the trauma. Our patient had an MCA syndrome at presentation however, clin- ical signs can be transient, subtle such as headache, neck pain," 554 948 W4386715379.pdf 3 6 caption 0.9965964 "Figure 5. Lateral (a, b) and frontal (c) projections of extracranial left carotid angiogram pre- (a) and post- (b, c) clot retrieval from carotid bifurcation. Images a and b show Emboshield filter (yellow arrowhead) deployed in left proximal cervical ICA over delivery guide wire advanced through an 8 Fr guide catheter. Non- flow limiting dissection flap is denoted by the orange arrowhead. ICA, internal carotid artery." 948 1379 W4386715379.pdf 3 7 separator 0.98788536 ¶ 1379 1381 W4386715379.pdf 3 8 caption 0.99627554 "Figure 6. Follow- up axial CTA shows no residual clot in the left CCA and reveals the underlying intraluminal dissection flap shown by the orange arrowhead (a). Patent left MCA branches (b). CTA, CT angiography; MCA, middle cerebral artery." 1381 1634 W4386715379.pdf 3 9 separator 0.9624413 ¶ 1634 1636 W4386715379.pdf 3 10 caption 0.99619454 Figure 7. Follow- up MRI diffusion- weighted sequence. 1636 1692 W4386715379.pdf 3 11 separator 0.90068066 ¶ 1693 1695 W4386715379.pdf 3 12 caption 0.67781395 Cortical and subcortical infarct in single pi 1695 1741 W4386715379.pdf 3 13 title 0.44654927 al artery 1741 1750 W4386715379.pdf 3 14 caption 0.4633925 1750 1751 W4386715379.pdf 3 15 text 0.4597795 territory 1751 1760 W4386715379.pdf 3 16 separator 0.5059295 ¶ 1761 1763 W4386715379.pdf 3 17 text 0.95676094 "of left MCA at the ganglionic level (a, b). Embolic- type left MCA territory cortical infarcts at supraganglonic level (yellow arrowheads). Punctate infarcts in internal subcortical (orange arrowheads) and external cortical (blue arrowheads) water- shed zones between left ACA/MCA vascular territories (c, d)." 1763 2084 W4386715379.pdf 3 18 separator 0.94171655 ¶ 2085 2087 W4386715379.pdf 3 19 text 0.4543661 ACA 2087 2091 W4386715379.pdf 3 20 caption 0.5134764 , 2091 2092 W4386715379.pdf 3 21 text 0.4754654 anterior cerebral artery; 2092 2118 W4386715379.pdf 3 22 caption 0.43556806 2118 2119 W4386715379.pdf 3 23 text 0.41096136 MCA 2119 2122 W4386715379.pdf 3 24 caption 0.48979154 , 2122 2123 W4386715379.pdf 3 25 text 0.42301223 middle cerebral artery. 2123 2147 W4386715379.pdf 3 26 separator 0.97840357 ¶ 2147 2149 W4386715379.pdf 3 27 paratext 0.97108597 Downloaded from https://academic.oup.com/bjrcr/article/9/6/20230048/7483270 by guest on 18 May 2024 2149 2249 W4386715379.pdf 3 28 separator 0.9960768 ¶ 2249 2251 W4386715379.pdf 3 0 paratext 0.74622697 Contreras-Briceño et al. 0 24 W3209798671.pdf 4 1 title 0.67058784 Cardiac Remodeling in Runners 24 54 W3209798671.pdf 4 2 separator 0.99477136 ¶ 54 56 W3209798671.pdf 4 3 caption 0.9940158 "FIGURE 2 | Blood samples levels of sVCAM-1. (A)At baseline conditions (1 week before marathon race). (B)Exercise-induced changes after marathon race (42.2km). (C)Comparison of changes ( /Delta1sVCAM-1 = post–pre-marathon) between runners’ groups. LT, low train ing (≥70 and <100 km·week−1) (n=18); HT, high training ( ≥100 km·week−1) (n=18). *= p-value <0.05." 56 426 W3209798671.pdf 4 4 separator 0.9930522 ¶ 426 428 W3209798671.pdf 4 5 text 0.97966534 "rehabilitation programs for patients with coronary heart dis ease (22) and chronic heart failure ( 23). International guidelines suggest 150min per week of moderate exercise or 75min per week of vigorous exercise for the general adult population ( 24). " 428 688 W3209798671.pdf 4 6 separator 0.53998935 ¶ 688 689 W3209798671.pdf 4 7 text 0.99786156 "However, a growing group of people performs 20 or more hours of intense exercise per week. These people demonstrate multiple adaptive cardiac changes, a condition called “athlete’s hea rt”" 689 882 W3209798671.pdf 4 8 separator 0.99219775 ¶ 882 884 W3209798671.pdf 4 9 caption 0.9951017 "FIGURE 3 | Correlation between sVCAM-1 blood sample levels and left at rial volume in long-distance runners ( n=36)." 884 1003 W3209798671.pdf 4 10 separator 0.94238734 ¶ 1003 1005 W3209798671.pdf 4 11 text 0.9938359 "(25,26). This cardiac remodeling process is an adaptation to the volume overload inherent to aerobic physical training; in most cases,itisconsideredareversibleandbenigncondition( 27)." 1005 1193 W3209798671.pdf 4 12 separator 0.9508124 ¶ 1193 1195 W3209798671.pdf 4 13 text 0.99906766 "In this study, we found that only HT athletes, not LT athletes, have significant changes in LV cardiac remodeling and LA volume. This result is concordant with previous data showing that intense training induces significant changes i n the size and function of the atrial syncytium ( 6). Pellicia et al. showed 20% mild atrial dilation and 2% severe LA dilation in a group of 1,777 competitive athletes ( 25). Our group included professional handball players ( 26) and marathon runners ( 9,28) with significant right atrial dilation; however, in this stu dy, the parameters of atrial deformation were preserved, unlike othe r pathological conditions with similar atrial dilation ( 29,30)." 1195 1901 W3209798671.pdf 4 14 separator 0.9354929 ¶ 1901 1903 W3209798671.pdf 4 15 text 0.9995278 "On the other hand, our results show that although the most trained runners had a higher-volume LA and thicker ventricu lar walls, they had a normal ejection fraction similar to the othe r studyparticipants." 1903 2116 W3209798671.pdf 4 16 separator 0.8790891 ¶ 2116 2118 W3209798671.pdf 4 17 text 0.99950635 "This study did not specifically evaluate LA function, which constitutes a limitation; however, we previously described that this function is particularly stressed during the performanc e of aerobicresistanceexerciseintrainedathleteswithchara cteristics similar to the runners studied here ( 8), a finding that is directly associated with ̇VO2-peak and sports performance ( 31). Our findings suggest that athletes with high-performance aerobi c resistancedeveloprightatrialandLAdilation,aconditio nthatis associatedwithlessatrialdeformationduringcontractio natrest (31). Our research group previously reported that this condition enables greater functional reserve but causes greater atri al wall stress (26). We also describe that a subgroup of athletes showed severe atrial dilation associated with a lower capacity to in crease atrialdeformationduringexercisecontraction,possiblyre sulting inearlyatrialdysfunction( 8)." 2118 3065 W3209798671.pdf 4 18 separator 0.93240905 ¶ 3065 3067 W3209798671.pdf 4 19 text 0.99919546 "Although risk prediction models for AF that incorporate clinical and genetic factors have been developed for the gene ral population, their discriminatory ability remains moderate ( 29," 3067 3257 W3209798671.pdf 4 20 separator 0.97206163 ¶ 3257 3259 W3209798671.pdf 4 21 paratext 0.9826318 Frontiers in Cardiovascular Medicine | www.frontiersin.o rg 5 November 2021 | Volume 8 | Article 737285 3259 3363 W3209798671.pdf 4 0 paratext 0.9722507 7 0 1 W4247906290.pdf 6 1 separator 0.99477834 ¶ 2 4 W4247906290.pdf 6 2 text 0.9981207 "Khususnya (-1)u (juga ditulis –u sama panjangnya dengan u arahnya berlawanan dengan u). Vektor ini disebut vektor negatif u sebab jika dijumlahkan dengan u hasilnya adalah vektor nol (yaitu suatu titik)." 5 216 W4247906290.pdf 6 3 separator 0.51786745 ¶ 218 220 W4247906290.pdf 6 4 text 0.9934882 "Vektor nol adalah satu -satunya vektor yang tanpa arah tertentu, dinamakan vektor nol dinotasikan dengan 0. V ektor ini merupakan unsur satuan penjumlahan yaitu u + 0 = 0 + u = u. Sehingga kita dapat mendefinisikan pengurangan sebagai : u - v = u + ( -v)." 220 482 W4247906290.pdf 6 5 separator 0.9969942 ¶ 483 485 W4247906290.pdf 6 6 title 0.9939776 3. Pembahasan Vektor dengan Pendekatan Aljabar 485 532 W4247906290.pdf 6 7 separator 0.9968064 ¶ 534 536 W4247906290.pdf 6 8 text 0.9991982 "Dari uraian terdahulu dengan pendekatan geometri dapat disimpulkan bahwa sebuah vektor adalah keluarga anak panah yang panjangnya dan arahnya sama. Sekarang kita akan membahas vektor secara aljabar. (lihat gambar dibawah)" 536 764 W4247906290.pdf 6 9 separator 0.9898012 ¶ 766 768 W4247906290.pdf 6 10 math 0.8518255 "Y (u1 , u2) ¶ Y" 771 811 W4247906290.pdf 6 11 separator 0.9504405 ¶ 812 814 W4247906290.pdf 6 12 text 0.9991565 "Kita mulai dengan mengambil sebuah sistem koordinat cartesius pa da bidang, sebagai wakil dari vektor u, kita pilih sebuah anak panah yang berpangkal dititik asal. Anak panah ini ditentukan secara tunggal oleh koordinat u 1 dan u 2 pada titik ujungnya; ini berarti bahwa vektor u ditentukan oleh pasangan terurut ." 814 1149 W4247906290.pdf 6 13 separator 0.7649883 ¶ 1150 1152 W4247906290.pdf 6 14 text 0.9992774 "Jadi selanjutnya kita anggap adalah vektor u. Pasangan terurut ini merupakan vektor secara aljabar. Kita gunakan simbol pasangan terurut karena (u 1 , u2) sudah mempunyai pengertian tersendiri yai tu koordinat titik pada b idang." 1152 1425 W4247906290.pdf 6 15 separator 0.99712884 ¶ 1427 1429 W4247906290.pdf 6 16 title 0.99311423 4. Panjang dan Hasil Kali Titik 1429 1461 W4247906290.pdf 6 17 separator 0.9969381 ¶ 1463 1465 W4247906290.pdf 6 18 text 0.9820929 Definisi : 1465 1476 W4247906290.pdf 6 19 separator 0.8006629 ¶ 1478 1480 W4247906290.pdf 6 20 text 0.99755466 "Jika u dan v adalah vektor – vektor di ruang 2 dan ruang 3 dan  adalah sudut di antara u dan v, maka hasil kali titik (dot product) atau hasil kali dalam euclidis (Euclidean inner product) u.v diddefinisikan oleh u.v = u v cos, jika u  0 dan v  0" 1480 1746 W4247906290.pdf 6 21 separator 0.59321725 ¶ 1747 1749 W4247906290.pdf 6 22 text 0.9690772 0, jika u = 0 dan v = 0 1749 1773 W4247906290.pdf 6 0 text 0.8100005 "¶ (C ෍௡ ௜ୀ eq th ac gr sh lo eq of fu is dr no ad tri fo pr se ap m ad suCardinal equa t" 1 136 W1434699048.pdf 1 1 math 0.4260165 ¶ 136 138 W1434699048.pdf 1 2 text 0.4345646 • Equili b 138 149 W1434699048.pdf 1 3 math 0.44690555 ¶ 149 151 W1434699048.pdf 1 4 text 0.44603866 the bo 151 158 W1434699048.pdf 1 5 math 0.42200002 ¶ • 158 162 W1434699048.pdf 1 6 text 0.401978 Equili b 162 171 W1434699048.pdf 1 7 math 0.38721642 ¶ 171 173 W1434699048.pdf 1 8 text 0.43651986 produ c 173 181 W1434699048.pdf 1 9 math 0.4912014 "¶ (see E ෍ ෍ܯ௫௜ ൌ 0௡ ୀଵ; ෍ ௜ ¶" 181 220 W1434699048.pdf 1 10 separator 0.67267424 ¶ 222 224 W1434699048.pdf 1 11 text 0.98509914 "If we take i n quilibrium co n he Eq.(1) and cting on the s ravity ( GሬሬԦ) and hown in Fig. 1 ." 224 331 W1434699048.pdf 1 12 separator 0.9902841 ¶ 331 333 W1434699048.pdf 1 13 caption 0.8350223 Fig. 1 333 340 W1434699048.pdf 1 14 separator 0.9481539 ¶ 340 342 W1434699048.pdf 1 15 text 0.5594384 As the we 342 352 W1434699048.pdf 1 16 title 0.47547317 ig h 352 356 W1434699048.pdf 1 17 text 0.52488756 ¶ 356 358 W1434699048.pdf 1 18 title 0.49124703 oa 358 361 W1434699048.pdf 1 19 text 0.47150466 ding 361 365 W1434699048.pdf 1 20 title 0.52858907 condit 365 373 W1434699048.pdf 1 21 text 0.40920773 ¶ 373 374 W1434699048.pdf 1 22 title 0.5942772 quilibrium 374 385 W1434699048.pdf 1 23 text 0.4125921 as 385 388 W1434699048.pdf 1 24 title 0.4496395 s 388 390 W1434699048.pdf 1 25 text 0.5123488 ¶ 390 392 W1434699048.pdf 1 26 title 0.47187263 f 392 394 W1434699048.pdf 1 27 text 0.4171954 application 394 406 W1434699048.pdf 1 28 title 0.4399457 d 406 408 W1434699048.pdf 1 29 text 0.4208973 ¶ 408 410 W1434699048.pdf 1 30 title 0.4837626 unctions of th 410 425 W1434699048.pdf 1 31 text 0.38357186 425 426 W1434699048.pdf 1 32 title 0.37838805 e 426 428 W1434699048.pdf 1 33 text 0.39710346 ¶ 428 429 W1434699048.pdf 1 34 caption 0.3359103 function 429 438 W1434699048.pdf 1 35 title 0.3829784 of t 438 444 W1434699048.pdf 1 36 text 0.29938993 ¶ 444 445 W1434699048.pdf 1 37 title 0.43558702 445 446 W1434699048.pdf 1 38 caption 0.4202783 raft ( ܶ .) 446 457 W1434699048.pdf 1 39 title 0.42494956 In 457 459 W1434699048.pdf 1 40 caption 0.49619794 o 459 461 W1434699048.pdf 1 41 title 0.33928576 461 462 W1434699048.pdf 1 42 caption 0.45487094 ¶ on-linear sy 462 476 W1434699048.pdf 1 43 title 0.40844184 s t ¶ 476 481 W1434699048.pdf 1 44 caption 0.45786262 daptive conve 481 495 W1434699048.pdf 1 45 title 0.39056006 ¶ im 495 500 W1434699048.pdf 1 46 caption 0.4113369 and 500 504 W1434699048.pdf 1 47 title 0.41133833 "heel orces and sum" 504 526 W1434699048.pdf 1 48 separator 0.879648 ¶ 527 529 W1434699048.pdf 1 49 text 0.9914047 "This paper p roblem of t h ectional app r pproach com e means of the v e dvantage of t urface used in tions of static s brium of forc e dy is zero) (s e brium of m ced by such q. (2))." 529 740 W1434699048.pdf 1 50 separator 0.45853066 ¶ 741 743 W1434699048.pdf 1 51 text 0.57006973 743 744 W1434699048.pdf 1 52 math 0.61086017 "෍ܨԦ௜ൌ0௡ ௜ୀଵ ¶" 744 760 W1434699048.pdf 1 53 text 0.5095916 760 761 W1434699048.pdf 1 54 math 0.4715365 ෍ܯ௬௜ 761 765 W1434699048.pdf 1 55 text 0.48847452 765 766 W1434699048.pdf 1 56 math 0.49852386 ൌ 766 767 W1434699048.pdf 1 57 text 0.5231811 0 767 769 W1434699048.pdf 1 58 math 0.5097142 ௡ ¶ 769 772 W1434699048.pdf 1 59 text 0.45773748 772 773 W1434699048.pdf 1 60 math 0.47177178 ୀଵ 773 775 W1434699048.pdf 1 61 text 0.53533685 ; 775 776 W1434699048.pdf 1 62 math 0.49865574 "෍ ௜ ¶" 776 783 W1434699048.pdf 1 63 text 0.59404486 nto account a 783 797 W1434699048.pdf 1 64 math 0.5045761 797 798 W1434699048.pdf 1 65 text 0.7579053 "¶ ndition, for a (2) are simp l system are t h d the buoyan c ." 798 870 W1434699048.pdf 1 66 separator 0.90907925 ¶ 871 873 W1434699048.pdf 1 67 text 0.94789684 "1 Forces which ht and centre o ion, they co u sessment. Ot h depend on th e e position of t the heel angl e order to eval u tem describe d rgence meth o angles are p of moments a presents two he evaluatio n roach and m es from the tr a ertical lines p l the three-di m modern CA D s): es (the sum o f ee Eq. (1)); moments (the forces respe c ෍ܯ௭௜ ൌ 0௡ ௜ୀଵ a body hull i n rigid body, i t lified becaus e he weight ( ∆ሬሬԦ) cy (ܵԦ) acting act on any flo a ¶ of gravity are uld be consi herwise the b u e hull geomet r the ship in th e e (ԂT), the tri m uate the equi l d above, it i ods, where it e performed un t acting on the s different app r n of equilib r mesh appro a aditional desc r lan while the mensional des D applications . f the forces a c sum of m ct to a polo i n order to as s t is worth not i e the only for c ) acting in c e in its centre ating object. both functio n dered fixed uoyancy and i t ry and are no n e water. This p m angle ( ԂL) librium cond i is necessary erations on t h til both sum ship are zero. roaches to s o rium conditi o ach. The s e ription of the mesh approa c cription of t h . cting on moments is zero) (1) (2) sess the ing that ces that entre of (ܤሬԦ), as ¶ ns of the for the ts point n-linear position and the ition of to use he draft, of the olve the on, i.e. ectional hull by ch takes he hull hu de at an bo tha the be co pro inc ge sec Th co the an trim rou co sho use ch the fin un ba wh app" 873 2623 W1434699048.pdf 1 68 separator 0.91577256 ¶ 2623 2625 W1434699048.pdf 1 69 title 0.5070635 "101020The Sectiona ull in terms veloped in-h o upright cond i nd in longitud i ody hull repre s " 2625 2733 W1434699048.pdf 1 70 text 0.5173423 "¶ at in Fig. 2 th e ship, while t" 2733 2769 W1434699048.pdf 1 71 separator 0.94770724 ¶ 2769 2771 W1434699048.pdf 1 72 caption 0.6897972 Fig. 2 Exa m 2771 2784 W1434699048.pdf 1 73 separator 0.91687167 ¶ 2784 2786 W1434699048.pdf 1 74 text 0.9924251 "The ship wa t tween the mputational operty of the clination: by a ometrical ch a ctional subm e hen by a long i mputed, e.g. t The second fe e righting ar m ngle. Calculati m, and super i utine is able ndition, any i m In Fig. 3 the own. In parti c es a geome t haracteristics ( e water ( ԂL,Ԃ nd the equilib r nder any (fea s ased on two here the de proximation o0 −1001001020III. SECTIO N l Approach u s of transvers a ouse [4]-[5] s o ition and at la r inal waves. I n sentation has b he blue lines the black one s mple of body h u terline is the r hull and u tool is abl e hull at any l o a numerical i n aracteristics erged area a n itudinal integ r the centre of b feature of the c m GZ, given a ons are carri e imposing the to find the mposed roll a n flow chart u cular, it is p o tric core in (SሬԦ,BሬሬԦ) starting ԂT,T), and a n rium conditi o sible) load c o one-dimens i rivatives ar e of them. 050NAL APPROA C ses as input t h al sections. oftware is to e rge angles fo r n the Fig. 2 a been present e represent the s show the en t ull input for Se c result of geo m undisturbed e to evalua t ongitudinal or ntegration ov e are evaluate d nd the bread t ration all glob a buoyancy and code focuses o a fixed volu m ed out consid e transversal a righting arm ngle. used inside th ossible to not e order to e v from the po s n iterative m e on, solving th e ondition. The ional Newto n e evaluated 0100CH he descriptio n The ability evaluate the s t r a ship in stil a sketch of t h ed. It is worth submerged p tire hull." 2786 4539 W1434699048.pdf 1 75 separator 0.7745041 ¶ 4540 4542 W1434699048.pdf 1 76 title 0.75868475 "ctional Approa c metrical inter s ¶" 4542 4580 W1434699048.pdf 1 77 text 0.9914832 "free surface te any geo m transversal a n er the sections d, for exam p th of the wa t al characteris t the hull volu m on the calcul a me and a tran ering the ship angle. Theref o (GZ) for a n e numerical c e that the pr o valuate the f sition of the s ethod that as s e non-linear s iterative me t n-Raphson m using an e0150n of the of the tability l water he used noting parts of ¶ ch section . The metrical ngle of all the ple the terline. tics are me. ation of sversal free to ore this ny load code is ocedure floating ship in sure to system, thod is method, explicit" 4580 5290 W1434699048.pdf 1 78 paratext 0.9752574 "World Academy of Science, Engineering and Technology International Journal of Physical and Mathematical Sciences Vol:7, No:1, 2013 56 International Scholarly and Scientific Research & Innovation 7(1) 2013 scholar.waset.org/1307-6892/3730International Science Index, Physical and Mathematical Sciences Vol:7, No:1, 2013 waset.org/Publication/3730" 5290 5644 W1434699048.pdf 1 0 paratext 0.9587154 "Mehmet ŞEN, Muciz ÖZCAN: Technoeconomic Analysis of 1 MWp Gr id Connected Solar Power Plant in Konya (Türkiye) Tehnički vjesnik 30, 6(2023), 1737- 1743 1739" 0 359 W4387954292.pdf 2 1 title 0.992843 2.2.1 Meteorological Details and Plant Layout 360 406 W4387954292.pdf 2 2 separator 0.98501354 ¶ ¶ 407 413 W4387954292.pdf 2 3 text 0.9995946 "The province of Konya, located in the south of the country, is quite good in terms of sunshine duration. The monthly incoming radiation value is 1608 kwh/m, which is above the national average. For this reason, Necmettin Erbakan University in Konya was preferred as the study area within the scope of be nefit/cost. Th erefore, the largest solar power plant of the country is in Konya with an installed power of 1348 MW. The location and energy capacity of Konya in the country are given in Fig. 3." 413 931 W4387954292.pdf 2 4 separator 0.95263296 "¶ ¶" 931 941 W4387954292.pdf 2 5 caption 0.9924349 Figure 3 Annual solar energy capacity and location of Konya in Türkiye [24] 941 1017 W4387954292.pdf 2 6 separator 0.866179 ¶ ¶ 1018 1024 W4387954292.pdf 2 7 text 0.99269515 "The monthly average radiation and temperature values for the region where the study is planned are obtained from the Türkiye Solar Energy Potential Atlas and are given in Tab. 1 [25]." 1024 1217 W4387954292.pdf 2 8 separator 0.9930577 ¶ ¶ 1218 1224 W4387954292.pdf 2 9 title 0.9746692 Table 1 Meteorological Details of Konya 1224 1265 W4387954292.pdf 2 10 table 0.6126046 1266 1267 W4387954292.pdf 2 11 separator 0.705532 ¶ 1267 1268 W4387954292.pdf 2 12 table 0.9942513 "Months Global Radiation / kWh/m2-day Sunshine Duration / Hour Türkiye Konya Türkiye Konya January 1.79 1.98 4.11 4.19 February 2.5 2.56 5.22 5.51 March 3.87 4.23 6.27 6.68 April 4.93 5.2 7.46 8.03 May 6.14 6.3 9.1 9.46 June 6.57 6.78 10.81 11.28 July 6.5 6.81 11.31 11.97 August 5.81 6.05 10.7 11.35 September 4.81 5.12 9.23 9.79 October 3.46 3.73 6.87 7.35 November 2.14 2.35 5.15 5.53 December 1.59 1.77 3.75 3.93 Average 4.18 4.41 7.49 7.92" 1268 1760 W4387954292.pdf 2 13 separator 0.94454324 ¶ ¶ 1761 1767 W4387954292.pdf 2 14 title 0.9888666 Table 2 Percentage of Various Losses 1767 1805 W4387954292.pdf 2 15 separator 0.963066 ¶ 1806 1808 W4387954292.pdf 2 16 table 0.9957429 "Losses PVGIS PVWatts PVsyst PV module nameplate DC rating 1% 1% 0.97% Diodes and connections 0.4% 0.3% 0.4% DC wiring 1.2% 1.2% 1.15% AC wiring 1% 1% 1% Shading 0.4% 0.5% 0.65% Module mismatch 2% 2% 2% Soiling 1% 2% 2% Inverter and transformer 6% 6% 6.09% Aging 1% 1% 1%" 1808 2109 W4387954292.pdf 2 17 separator 0.98209906 ¶ 2110 2112 W4387954292.pdf 2 18 text 0.9995238 "The slope is critical for solar power plants to maximize sunlight absorption. It was calculated as 36° in the review in the PVGIS soft ware tool. This PV power plant solar panel is monocrystalline. It has one solar panel rated at 235 W and requires 4260 units. In addition to these methods, the techniques and analyses that can be used are important. Percentage of miscellaneous losses is given in Tab. 2." 2113 2534 W4387954292.pdf 2 19 separator 0.9908947 ¶ ¶ 2535 2541 W4387954292.pdf 2 20 title 0.99280703 2.2.2 Methodology of Performance Analysis 2541 2583 W4387954292.pdf 2 21 separator 0.9935017 ¶ ¶ 2584 2590 W4387954292.pdf 2 22 text 0.99958277 "Estimating the amount of energy to be produced by the planned solar power plants is critical. Some issues must be addressed in order for these estimates to be consistent. One of the most important factors to consider when investing in ground-mounted solar power plants is the location of the system. This issue will be critical to the performance of the new power plant. During the planning phase, the solar radiation of the panels and the calculation of the nominal energy of the system should be considered." 2590 3115 W4387954292.pdf 2 23 separator 0.9636289 ¶ 3116 3118 W4387954292.pdf 2 24 text 0.9866305 "The daily solar radiation event in an inclined PV plant with atmospheric conditions is calculated as shown in Eq. (1)." 3118 3240 W4387954292.pdf 2 25 separator 0.92745906 ¶ ¶ 3241 3247 W4387954292.pdf 2 26 math 0.92075396 "at To1c o s 1c o s(1 )22Td T HR KH               (1)" 3247 3339 W4387954292.pdf 2 27 separator 0.43203074 3341 3342 W4387954292.pdf 2 28 math 0.5371965 ¶ 3342 3343 W4387954292.pdf 2 29 text 0.3116687 3345 3346 W4387954292.pdf 2 30 math 0.37408835 ¶ 3346 3347 W4387954292.pdf 2 31 text 0.9346654 "where KT represents the aperture index, Rd represents the slope factor, T represents the overall slope f actor, is the ¶" 3347 3472 W4387954292.pdf 2 0 paratext 0.9902279 Gels 2024 ,10, 113 8 of 19 0 26 W4391431142.pdf 7 1 separator 0.9945377 ¶ 26 28 W4391431142.pdf 7 2 text 0.9996715 "The tensile test (Figure 5a) revealed the influence of the chelating agents on the mechanical resistance of the hydrogels. Except the sample containing 1,3-diamino-2- hydroxypropane-N,N,N′,N′-tetraacetic acid (TETRA), all the other hydrogels incorporated chelating agents displayed a slightly higher mechanical resistance than the blank sample." 28 379 W4391431142.pdf 7 3 separator 0.891634 ¶ 379 381 W4391431142.pdf 7 4 text 0.9997609 "The slight differences between the tensile resistance of the hydrogels containing chelating agents may appear due to the distinct ionic interactions established with the NVP moieties from the IPN. The sample containing phytic acid led to the highest ultimate stress values, probably due to the significant strengthening effect [ 6,44] of supplementary H-bonding interactions established with the NVP and AMPSA moieties. The amount of chelating groups, thus the supplementary interactions established, influence the density of the network and, thus, the mechanical resistance of the hydrogels. The compression tests (Figure 5b), performed on samples in their equilibrium swollen state, revealed lower stress values and higher strain values for the hydrogels containing chelating agents. This behavior can be explained by their anisotropy [ 43] but also through their higher swelling degrees, which imply a higher water content and a lower stiffness [ 45]. The viscoelasticity of hydrogels can be correlated with their microstructures, which may offer valuable insights for adjusting their performance characteristics. The viscoelastic properties of hydrogels depend on their composition but also on the interactions established with the liquid confined in their 3D polymeric network. The storage and loss moduli (Figure 5c,d) describe the viscoelastic properties of the synthesized hydrogel films. All samples revealed that storage moduli (G′) values were greater than (G′′) values, which is a common characteristic of crosslinked hydrogels [ 46]. A higher storage modulus (G′) indicates that elastic behavior becomes dominant, while the influence of the viscous behavior is diminished [ 47], as frequency increases. An important technique employed in the characterization of hydrogels is small-amplitude oscillatory shear (SAOS) [ 48]. Important details about gel structure and mechanical behavior can be deduced from the frequency dependence of the dynamic moduli G′and G′′in the linear-viscoelastic regime (LVE) [ 48]. Since rheometers have limited sensitivity, choosing the applied strain amplitude requires finding a balance between the requirement to preserve sample integrity and the necessity to give a sufficiently strong signal. Thus, the hydrogels reported herein were analyzed in frequency sweep mode, on a frequency range between 0.1–10 Hz, at a constant oscillation strain of 10%. Tan delta ( δ) shows the ratio of the viscous to elastic effects and reveals how the sample transitions from solid- to liquid-like behavior as a function of the experimental timescale (Figure 5e). When tan δ> 1, it indicates that G′′has a superior value than G′and that the material is more viscous, allowing for greater energy dissipation; however, when tan delta < 1 , it indicates that G′has a greater value than G′′and that the material is elastic [ 49]." 381 3296 W4391431142.pdf 7 5 separator 0.96352816 ¶ 3296 3298 W4391431142.pdf 7 6 text 0.9997623 "Thus, the tan delta plot also confirms the elastic behavior tendency of the herein-reported crosslinked hydrogels. However, samples with greater tan δvalues tend to have a more viscous character. Complex viscosity measurements [ 23] (Figure 5f) can be associated with hydrogel structural strength, and they revealed that all hydrogels possess pseudoplastic properties [ 50]. The increase in the shear rate leads to a deformation of the polymeric chain entanglements as a result of the breakdown of physical interactions, resulting in a decrease in the viscosity values." 3298 3880 W4391431142.pdf 7 7 separator 0.9969096 ¶ 3880 3882 W4391431142.pdf 7 8 title 0.99317193 2.6. Hg2+Decontamination Survey 3882 3914 W4391431142.pdf 7 9 separator 0.9966793 ¶ 3914 3916 W4391431142.pdf 7 10 text 0.9997226 "To evaluate their ability to entrap, detect, and remove the Hg2+ions from an aqueous solution, the aerogels (containing RTTA and a chelating agent) were immersed in a HgCl 2 aqueous solution. After 48 h, they were removed from the decontaminated aqueous solution and allowed to dry." 3916 4205 W4391431142.pdf 7 11 separator 0.8029963 ¶ 4205 4207 W4391431142.pdf 7 12 text 0.9997092 "As can be observed from Figure 6, this method allows a fast, efficient route for confirm- ing the presence of Hg2+, but could also allow a qualitative evaluation of the mercury levels." 4207 4394 W4391431142.pdf 7 13 separator 0.9598335 ¶ 4394 4396 W4391431142.pdf 7 14 text 0.99975395 "Initially, at low Hg2+concentrations, the fluorescence is increased due to a fluorescence “on” effect (Scheme S1); however, at higher Hg2+concentrations and due to the high RTTA amount in the aerogels, the fluorescence is gradually turned off [ 51,52]. The fluorogenic" 4396 4669 W4391431142.pdf 7 0 paratext 0.9904461 J. Clin. Med. 2020 ,9, 2566 6 of 17 0 35 W3048134203.pdf 5 1 separator 0.9948195 ¶ 35 37 W3048134203.pdf 5 2 text 0.9992329 "Qualitative variables are summarized as count and percentage, comparisons between independent groups were performed by 2test or Fisher’s exact test when appropriate. In order to compare the percentages of side e ects, a multiple comparison strategy was applied: the statistical Fisher’s exact test was used, and p-values were adjusted according to a permutation method for the purpose of controlling family wise error rate." 37 471 W3048134203.pdf 5 3 separator 0.957384 ¶ 471 473 W3048134203.pdf 5 4 text 0.9993086 An ordinal logistic model was performed to evaluate predictors of changes in CGI-I and CGI-S. 473 567 W3048134203.pdf 5 5 separator 0.81610405 ¶ 567 569 W3048134203.pdf 5 6 text 0.9964552 "The model for CGI-S had DCGI-S as dependent variable, defined as the di erence obtained subtracting the CGI-S score at T24 from the CGI-S score at T0, classified as neutral (0) and classes of increasing improvement (from" 569 793 W3048134203.pdf 5 0 paratext 0.9847045 "BioEduVol.10No.2Tahun2021 Hal:360-366 https://ejournal.unesa.ac.id/index.php/bioedu" 0 85 W3170238300.pdf 6 1 separator 0.95502675 ¶ 85 87 W3170238300.pdf 6 2 bibliography 0.9864521 Wardhani,M.RifqiEka&Fitrihidajati,Herlina:ValiditasPerangkatPembelajaranBerkalaIlmiahPendidikanBiologi 87 190 W3170238300.pdf 6 3 separator 0.99075973 ¶ 190 192 W3170238300.pdf 6 4 title 0.88240194 366DAFTARPUSTAKA 192 209 W3170238300.pdf 6 5 separator 0.99278975 ¶ 209 211 W3170238300.pdf 6 6 bibliography 0.9961485 "Ibrahim,Muslimin.2012.PembelajaranBerdasarkan Masalah.Surabaya:UnesaUniversityPress." 211 298 W3170238300.pdf 6 7 separator 0.96988165 ¶ 298 300 W3170238300.pdf 6 8 bibliography 0.9927387 "Ibrahim,Muslimin.2012.PelatihanTerintergasi berbasisKompetensiGuruMataPelajaranBiologi (pengembanganPerangkatPembelajaran).Jakarta: Depdiknas" 300 448 W3170238300.pdf 6 9 separator 0.9808826 ¶ 448 450 W3170238300.pdf 6 10 bibliography 0.99590653 "Kusnia,Aida.2018.LKPDBerbasisPBLUntuk MelatihkanKemampuanBerpikirKreatif.Surabaya: Unesa" 450 543 W3170238300.pdf 6 11 separator 0.97525495 ¶ 543 545 W3170238300.pdf 6 12 bibliography 0.9964704 "Munandar,Utami.2010.PengembanganKreativitas AnakBerbakat.Jakarta:PT.RinekaCipta." 545 628 W3170238300.pdf 6 13 separator 0.97995365 ¶ 628 630 W3170238300.pdf 6 14 bibliography 0.9847978 "Purnamaningrum,Arifah.2012.“Peningkatan KemampuanBerpikirkreatifMelaluiPBL(PBL)pada PembelajaranBiologiPesertadidikKelasXSMANegeri 3Surakarta”.JurnalPendidikanBiologi.Surakarta: UniversitasSebelasMaret" 630 840 W3170238300.pdf 6 15 separator 0.9904702 ¶ 840 842 W3170238300.pdf 6 16 bibliography 0.9767501 "Putra,TomiTridaya.,Irwan&DodiVionanda.2012. MeningkatkanKemampuanBerpikirKreatifPesertadidik DenganPembelajaranBerbasisMasalah." 842 974 W3170238300.pdf 6 17 separator 0.97891146 ¶ 974 976 W3170238300.pdf 6 18 bibliography 0.9927657 "Riduwan.2013.Skala-SkalaPengukuranVariabel- VariabelPenelitian.Bandung:Alfabeta." 976 1059 W3170238300.pdf 6 19 separator 0.9405626 ¶ 1059 1061 W3170238300.pdf 6 20 bibliography 0.99257785 "Rusmono.2014.StrategiPembelajarandenganPBL ituPerlu:untukMeningkatkanProfesionalitasGuru." 1061 1153 W3170238300.pdf 6 21 separator 0.93924254 ¶ 1153 1155 W3170238300.pdf 6 22 bibliography 0.9836923 "Bogor:GhaliaIndonesia.Subali,Bambang.2011.“PengukuranKreativitas KeterampilanProsesSainsdalamKonteksAssessment " 1155 1269 W3170238300.pdf 6 23 separator 0.57068217 ¶ 1269 1270 W3170238300.pdf 6 24 bibliography 0.99649656 ForLearning”.JurnalCakrawalaPendidikan,1. 1270 1312 W3170238300.pdf 6 0 title 0.97002685 Mixed-State Entanglement from Local Randomized Measurements 0 59 W4287330717.pdf 0 1 separator 0.9963329 ¶ 59 61 W4287330717.pdf 0 2 contact 0.6324613 "Andreas Elben ,1,2,*Richard Kueng,3,*Hsin-Yuan (Robert) Huang ,4,5Rick van Bijnen ,1,2 Christian Kokail,1,2Marcello Dalmonte" 61 188 W4287330717.pdf 0 3 table 0.50236785 ,6,7 188 192 W4287330717.pdf 0 4 contact 0.6029455 Pasquale Calabrese 192 210 W4287330717.pdf 0 5 table 0.4846757 , 210 211 W4287330717.pdf 0 6 contact 0.49662402 6,7, 211 215 W4287330717.pdf 0 7 table 0.47125575 8 215 216 W4287330717.pdf 0 8 contact 0.552936 "Barbara Kraus ,9 John Preskill" 216 248 W4287330717.pdf 0 9 table 0.584579 ,4,5,10,11Peter 248 264 W4287330717.pdf 0 10 contact 0.51031417 Zoller 264 271 W4287330717.pdf 0 11 table 0.5498646 , 271 272 W4287330717.pdf 0 12 contact 0.6158453 1,2and Benoît Vermersch1,2,12 272 301 W4287330717.pdf 0 13 separator 0.9861275 ¶ 301 303 W4287330717.pdf 0 14 contact 0.9840968 "1Center for Quantum Physics, University of Innsbruck, Innsbruck A-6020, Austria 2Institute for Quantum Optics and Quantum Information of the Austrian Academy of Sciences, Innsbruck A-6020, Austria 3Institute for Integrated Circuits, Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria 4Institute for Quantum Information and Matter, Caltech, Pasadena, California 91125, USA 5Department of Computing and Mathematical Sciences, Caltech, Pasadena, California 91125, USA 6The Abdus Salam International Center for Theoretical Physics, Strada Costiera 11, 34151 Trieste, Italy 7SISSA, via Bonomea 265, 34136 Trieste, Italy 8INFN, via Bonomea 265, 34136 Trieste, Italy 9Institute for Theoretical Physics, University of Innsbruck, A6020 Innsbruck, Austria 10Walter Burke Institute for Theoretical Physics, Caltech, Pasadena, California 91125, USA 11AWS Center for Quantum Computing, Pasadena, California 91125, USA 12Universit ́ e Grenoble Alpes, CNRS, LPMMC, 38000 Grenoble, France" 303 1321 W4287330717.pdf 0 15 separator 0.8697888 ¶ 1321 1323 W4287330717.pdf 0 16 paratext 0.9743867 (Received 22 July 2020; accepted 20 October 2020; published 11 November 2020) 1323 1401 W4287330717.pdf 0 17 separator 0.9912466 ¶ 1401 1403 W4287330717.pdf 0 18 text 0.998487 "We propose a method for detecting bipartite entanglement in a many-body mixed state based on estimating moments of the partially transposed density matrix. The estimates are obtained by performinglocal random measurements on the state, followed by postprocessing using the classical shadows framework. Our method can be applied to any quantum system with single-qubit control. We provide a detailed analysis of the required number of experimental runs, and demonstrate the protocol usingexisting experimental data [Brydges et al. ,Science 364, 260 (2019) ]." 1403 1967 W4287330717.pdf 0 19 separator 0.8524534 ¶ 1967 1969 W4287330717.pdf 0 20 paratext 0.9743663 DOI: 10.1103/PhysRevLett.125.200501 1969 2005 W4287330717.pdf 0 21 separator 0.9952929 ¶ 2005 2007 W4287330717.pdf 0 22 text 0.9994467 "Engineered quantum many-body systems exist in today ’s laboratories as noisy intermediate scale quantum devices (NISQ) [1]. This provides us with novel opportunities to study and quantify entanglement —a fundamental concept in both quantum information theory [2]and many-body quantum physics [3,4]. For pure (or nearly pure) states, entanglement has been detected by measuring the second R ́enyi entropy [5–10]. This has been achieved via, for instance, many-body quantum interference [7–9,11,12] (see also Refs. [13,14] ) and randomized measurements [10,15 –18]. However, many states of interest are actually highly mixed —either because of decoherence, or because they describe interesting subregions of a larger, globally entangled, system. Developing protocols which detect and quantify mixed-state entanglement on intermediate scale quantum devices is thus an outstanding challenge." 2007 2924 W4287330717.pdf 0 23 separator 0.98695445 ¶ 2924 2926 W4287330717.pdf 0 24 text 0.99608195 "Below we propose and experimentally demonstrate conditions for mixed-state entanglement and measurement protocols based on the positive partial transpose (PPT) condition [2,5,19] . Consider two partitions Aand B described by a (reduced) density matrix ρAB. The well- known PPT condition checks if the partially transposed (PT) density matrix ρTA AB[20] is positive semidefinite, i.e., all eigenvalues are non-negative. If the PPT condition is violated —i.e., ρTA ABdoes have negative eigenvalues —AandBmust be entangled. It is possible to turn the PPT condition into a quantitative entanglement measure. Thenegativity Nðρ ABÞ1⁄4P λ<0jλj, with λthe spectrum of ρTA AB, is positive if and only if the underlying state ρABviolates the PPT condition [21]. While applicable to mixed states, computing the negativity requires accurately estimating the full spectrum of ρTA AB. We bypass this challenge by consid- ering moments of the partially transposed density matrix(PT moments) instead:" 2926 3949 W4287330717.pdf 0 25 separator 0.97363484 ¶ 3949 3951 W4287330717.pdf 0 26 math 0.943581 "p n1⁄4Tr1⁄2ðρTA ABÞn/C138forn1⁄41;2;3;...: ð1Þ" 3951 3994 W4287330717.pdf 0 27 separator 0.94696033 ¶ 3994 3996 W4287330717.pdf 0 28 text 0.9982422 "These have been first studied in quantum field theory to quantify correlations in many-body systems [22]. Clearly, p11⁄4trðρABÞ1⁄41, while p2is equal to the purity tr 1⁄2ρ2 AB/C138 (see Table I in the Supplemental Material [23] for a visual derivation). Hence, p3is the lowest PT moment that captures meaningful information about the partial transpose (see also Ref. [29])." 3996 4378 W4287330717.pdf 0 29 separator 0.83642995 ¶ 4378 4380 W4287330717.pdf 0 30 text 0.99723524 "In this Letter, we first show that the first three PT moments can be used to define a simple yet powerful test for bipartite entanglement:" 4380 4523 W4287330717.pdf 0 31 separator 0.87047946 ¶ 4523 4525 W4287330717.pdf 0 32 text 0.4973739 4525 4526 W4287330717.pdf 0 33 math 0.73202515 ρAB∈ 4526 4530 W4287330717.pdf 0 34 text 0.5170846 PPT 4530 4533 W4287330717.pdf 0 35 math 0.80730957 ⇒p3≥p2 4533 4539 W4287330717.pdf 0 36 separator 0.99044055 ¶ 4539 4541 W4287330717.pdf 0 37 paratext 0.78687626 2: ð2ÞPHYSICAL REVIEW LETTERS 125, 200501 (2020) 4541 4590 W4287330717.pdf 0 38 separator 0.82951546 ¶ 4590 4592 W4287330717.pdf 0 39 paratext 0.97026634 0031-9007 =20=125(20) =200501(6) 200501-1 © 2020 American Physical Society 4592 4667 W4287330717.pdf 0 0 paratext 0.98662215 Melo RCJ, Souza IEO, Paula CC.660 0 33 W1629637971.pdf 4 1 separator 0.57410896 33 34 W1629637971.pdf 4 2 paratext 0.9625482 ¶ Rev Bras Enferm. 2013 set-out; 66(5): 656-62. 34 81 W1629637971.pdf 4 3 text 0.9996076 "tende ao fechamento. Isso se dá no distanciamento do ser como se fosse levado pelo destino. A descrição da vida cotidia - na é considerada como forma de existência inautêntica. Con - siste no fato de estar jogado no mundo (conjunto de condições geográficas, históricas, sociais e econômicas, em que cada um está imersa), sem que sua vontade tenha participado disso." 82 458 W1629637971.pdf 4 4 separator 0.71144855 ¶ 458 460 W1629637971.pdf 4 5 text 0.9995034 "Esse sentido existencial não exprime qualquer avaliação negativa, mas indica como a presença, na maioria das vezes e quase sempre, se mostra no cotidiano: de modo impessoal." 460 640 W1629637971.pdf 4 6 separator 0.8889257 ¶ 641 643 W1629637971.pdf 4 7 text 0.99972236 "A inautenticidade significa o desvio de cada indivíduo de seu projeto essencial em favor das ocupações cotidianas, confun - dindo-o com a massa coletiva, em que, sendo todos, não é si mesmo, ou seja, ser todos é ser ninguém. O eu individual seria sacrificado ao persistente e opressivo todos nós. O ser em sua vida cotidiana é um ser público, e não um ser próprio, reduzin - do sua vida a vida junto aos outros e para os outros, alienando - -se da principal tarefa, que seria o tornar-se si mesmo(13)." 643 1164 W1629637971.pdf 4 8 separator 0.98163575 ¶ 1164 1166 W1629637971.pdf 4 9 text 0.9974292 "O ser-mãe-que-tem-a-possibilidade-de-tocar-seu-filho-pre - maturo-na-UTIN expressa ver a melhora do bebê, avaliando que está sendo bem cuidado, bem tratado e com uma apa - rência melhor. [...] mas ela foi bem cuidada, bem tratada, a equipe é super atenciosa com as crianças, só subiu quando tiveram a cer - teza que estava bem. (Ariadne mãe de Pérola); [...] eu sabia que ela estava sendo bem tratada, pois estava em boas mãos, eu ter visto aquela coisinha pequena se mexendo [pausa] ali com vida; vê que tinha os profissio - nais que estavam cuidando com amor e carinho, eu sabia e subia bem, [...]. (Sofia mãe de Safira); [...] mas eu vi que meu filho tá bem, que os profissionais estão fazendo um ótimo trabalho e que tudo depende da recuperação do neném mesmo, vejo que está recuperan - do, que está dando resultado. (Circe mãe de Ônix)." 1166 2038 W1629637971.pdf 4 10 separator 0.98066974 ¶ 2038 2040 W1629637971.pdf 4 11 text 0.99912065 "O ser-mãe atribuía aos profissionais de saúde da unidade a melhora nas condições de saúde de seu filho. Embora estivesse junto ao bebê não conseguia compreender a importância de sua presença. Mostra-se absorvida pela ocupação no mundo próprio da UTIN. A ocupação indica um modo deficiente de se omitir e (des)cuidar, visto manter-se ocupado com as coisas que devem ser feitas, sem se preocupar com as pessoas. Sustenta - -se na objetividade sem compreender a subjetividade. Pode designar um realizar e cumprir algo, desviando o ser para um entendimento imediato como ser simplesmente dado. Portanto “o seu ser para com o mundo, é essencialmente ocupação” (13)." 2040 2722 W1629637971.pdf 4 12 separator 0.9690628 ¶ 2722 2724 W1629637971.pdf 4 13 text 0.9996858 "Assim, o ser-mãe se mantém como está prescrito que deve viver, ou seja, no modo impessoal, impróprio e da inautentici - dade(13). Os limites de sua abertura para o mundo restringem suas possibilidades, a mãe, ao ser ocupar do filho, apresen - tou-se no modo de preocupação deficiente; presa ao modo prescrito de cuidado guiado por normas e rotinas instituídas pela UTI. Nesse modo, o ser-mãe se mantém presa aos fatos sem compreender autenticamente o que está acontecendo, apenas repete àquilo as informações e afazeres (13).O ser-mãe-que-tem-a-possibilidade-de-tocar-seu-filho-pre - maturo-na-UTIN entende que poderia tocar, sendo cuidadosa e cautelosa por ser um bebê pequenininho que necessita ain - da de proteção." 2724 3467 W1629637971.pdf 4 14 separator 0.98020196 ¶ 3467 3469 W1629637971.pdf 4 15 text 0.98889345 Ah, quando a gente vê assim, né, não sabe o que fazer, uma coisinha tão miudinha [...] (Themis mãe de Topázio); 3469 3582 W1629637971.pdf 4 16 separator 0.4936692 ¶ 3582 3583 W1629637971.pdf 4 17 text 0.99680996 "Falaram que podia botar a mão, a gente fica com medo porque é muito pequenininho, aí eu botei a mãozinha. (Íris mãe de Ágata);" 3583 3716 W1629637971.pdf 4 18 separator 0.80897415 ¶ 3716 3718 W1629637971.pdf 4 19 text 0.9995105 "Eu fiquei com medo no começo de tocar, com medo de prejudicar ele, fazer mal, porque ele estava ali achei que podia passar alguma coisa [...] eu fiquei com medo, de prejudicar meu filho, pegar um neném tão pequeno [...] (Circe mãe de Ônix)." 3718 3965 W1629637971.pdf 4 20 separator 0.9767869 ¶ 3965 3967 W1629637971.pdf 4 21 text 0.9997181 "A mãe a ter a possibilidade de tocar o filho, começa a to - cá-lo ao seu modo, com medo, devagar, com as pontas dos dedos. De modo que a presença passa a se relacionar com o filho de início em suas possibilidades: com base no falató - rio (em que repete aquilo que ouviu sem compreender), na ambigüidade (quando parece ter compreendido tudo, mas no fundo não compreendeu o que está acontecendo), fren - te ao temor diante da situação vivenciada (aquilo que teme possui um caráter de ameaça, pois pode acontecer ou não)." 3967 4509 W1629637971.pdf 4 22 separator 0.6777402 ¶ 4510 4512 W1629637971.pdf 4 23 text 0.99945855 "O falatório, a ambiguidade e o temor são modos de ser da inautenticidade(13)." 4512 4593 W1629637971.pdf 4 24 separator 0.96970433 ¶ 4593 4595 W1629637971.pdf 4 25 text 0.9996024 "Quando ser-mãe-que-tem-a-possibilidade-de-tocar-seu-filho - -prematuro-na-UTIN sente-se mais próxima do bebê entenden - do que ele sente uma força, um calor e uma energia positiva neste contato que é de troca." 4595 4809 W1629637971.pdf 4 26 separator 0.49920982 ¶ 4809 4811 W1629637971.pdf 4 27 text 0.99590546 "Eu sinto ela mais próxima, e ela também deve sentir a mes - ma coisa. (Afrodite mãe de Cristal); [...] fui começando a me aproximar mais, de mim com ele. Então nós dois vivos, um tocando no outro, um sentindo o corpo do outro, o calor do outro. (Ártemis mãe de Rubi); [...] porque a criança recebendo o carinho da mãe a re - cuperação é sempre mais rápida, eu conversava com ela, sentia que eu estava com ela. (Ariadne mãe de Pérola)." 4811 5264 W1629637971.pdf 4 28 separator 0.9688594 ¶ 5264 5266 W1629637971.pdf 4 29 text 0.9996178 "Ao estar-com-o-filho no cotidiano da UTIN e contar com a solicitude dos profissionais, a mãe caminha para a compre - ensão de suas possibilidades e de seu filho. Compreende o risco de melhora ou de piora do filho por ser pequeno e a importância de ser-presença." 5266 5536 W1629637971.pdf 4 30 separator 0.8713876 ¶ 5536 5538 W1629637971.pdf 4 31 text 0.9995065 "Dessa maneira transita da inautenticidade da ocupação para a autenticidade da preocupação. Passando a compreen - der o tocar como uma possibilidade de proximidade do bebê, que permite a energia de troca. Esse movimento de autentici - dade que emerge da cotidianidade." 5538 5818 W1629637971.pdf 4 32 separator 0.9673593 ¶ 5818 5820 W1629637971.pdf 4 33 text 0.9926488 "O cuidado como processo de constituição da presença se dá no acontecer, isto é, na dimensão da temporalidade." 5820 5933 W1629637971.pdf 4 0 paratext 0.9873996 Chomcheonetal. AdvancesinDifferenceEquations (2019) 2019:274 Page10of18 0 77 W2954462965.pdf 9 1 separator 0.99636173 ¶ 77 79 W2954462965.pdf 9 2 caption 0.9934622 Figure2 Timeseries.Numericalsimulationofourmodelshowingthetimeseriesof( a)levelofsensitive 79 170 W2954462965.pdf 9 3 separator 0.9894669 ¶ 170 172 W2954462965.pdf 9 4 caption 0.84875387 bacteria,( b)levelofresistantbacteria,and( c)nutrientconcentration,correspondingtothecaseseeninFig. 1. 172 275 W2954462965.pdf 9 5 separator 0.95079494 ¶ 275 277 W2954462965.pdf 9 6 text 0.7739367 "Here,x(0)=0.3,y(0)=0.4,z(0)=0.5,a1=2.407407, a2=0.023077, a3=0.00196, a4=0.0007, ω1=0.7, ω2=0.7,ω3=0.7" 277 382 W2954462965.pdf 9 7 math 0.483889 K 382 383 W2954462965.pdf 9 8 text 0.51925766 s=0.7, 383 389 W2954462965.pdf 9 9 math 0.5183159 Kγ 389 391 W2954462965.pdf 9 10 text 0.50005656 =4.3,KR= 391 399 W2954462965.pdf 9 11 math 0.4835169 5.0 399 402 W2954462965.pdf 9 12 text 0.5439625 ,εr=0.9, 402 410 W2954462965.pdf 9 13 math 0.5890108 γ 410 411 W2954462965.pdf 9 14 text 0.5024988 = 411 412 W2954462965.pdf 9 15 math 0.49553594 4.0 412 415 W2954462965.pdf 9 16 text 0.5620905 ,μ=0.01,z∗=5.0,and ψR=1.2 415 440 W2954462965.pdf 9 17 separator 0.96521413 ¶ 440 442 W2954462965.pdf 9 18 text 0.97204846 Wecanshowthefollowingresultinastraightforwardmanner. 442 495 W2954462965.pdf 9 19 separator 0.9713988 ¶ 495 497 W2954462965.pdf 9 20 text 0.8838913 Lemma2 (Nonnegativity) Suppose(x(t),y(t),z(t))isasolutionof (32)–(33)withφi(0)≥0, 497 579 W2954462965.pdf 9 21 separator 0.507252 ¶ 579 581 W2954462965.pdf 9 22 text 0.9157984 i=1,2,3.Thenx(t)≥0,y(t)≥0,and z(t)≥0forallt ≥0. 581 629 W2954462965.pdf 9 0 paratext 0.89772415 Rev Odontol UNESP . 2015 July-August; 44(4): 207-212 Efeito da intensidade de fontes de luz... 211 0 100 W1782117679.pdf 4 1 separator 0.9851612 ¶ 100 102 W1782117679.pdf 4 2 text 0.99945855 "As cerâmicas empregadas para infraestruturas de coroas protéticas são, relativamente, mais opacas do que aquelas empregadas para cobertura. Essa característica de opacidade se deve ao maior conteúdo cristalino da cerâmica de infraestrutura, necessário para reforçar a estrutura da coroa protética10,14. Assim, apesar de contribuir com o reforço da restauração indireta, a estrutura interna da cerâmica pode afetar a transmissão de luz, principalmente sob a restauração19. Apesar da clara tendência em reduzir o grau de conversão, de acordo com o tipo cerâmico, não houve diferença significativa entre o grupo controle e o cimento polimerizado por meio da cerâmica à base de zircônia, quando polimerizados pela unidade de luz visível de intensidade a 1.000 mW/cm2." 102 899 W1782117679.pdf 4 3 separator 0.9680727 ¶ 899 901 W1782117679.pdf 4 4 text 0.99970543 "Kilinc et al.14 avaliaram o efeito da cor e da espessura da cerâmica sobre a microdureza de vários cimentos resinosos e concluíram que a polimerização foi adversamente afetada apenas quando a espessura de cerâmica mostrou-se acima de 3 mm. Dessa forma, menores valores de microdureza foram obtidos quando comparados a cerâmicas com espessuras inferiores, sendo que isso ainda está diretamente relacionado a uma redução na transmissão de luz. A espessura da zircônia utilizada neste estudo foi menor que 3 mm, o que poderia justificar os valores semelhantes para microdureza do cimento resinoso para o grupo controle e sob a cerâmica à base de zircônia." 901 1584 W1782117679.pdf 4 5 separator 0.85385454 ¶ 1584 1586 W1782117679.pdf 4 6 text 0.99971247 "Esse efeito também pôde ser observado para o cimento quando polimerizado pela unidade de luz visível de intensidade a 1.000 mW/cm2 sob a cerâmica à base de espinélio MgAl2O4, em que diferença significativa não pode ser observada quando comparado ao grupo controle. Essa diferença pode ser explicada pela composição dos discos cerâmicos à base de espinélio MgAl2O4, a qual consiste em um material cerâmico à base de óxido de alumínio (Al2O3)." 1586 2046 W1782117679.pdf 4 7 separator 0.93116826 ¶ 2047 2049 W1782117679.pdf 4 8 text 0.99970275 "Entretanto, parte do Al2O3, da estrutura original desta cerâmica, é substituída por óxido de magnésio (MgO), formando o espinélio aluminato de magnésio (MgAl2O4). Essa nova estrutura de óxidos aumenta a translucidez do material, fato este resultante do baixo índice de refração do aluminato de magnésio e da matriz de vidro20, justificando os resultados obtidos neste estudo." 2049 2440 W1782117679.pdf 4 9 separator 0.9483334 ¶ 2440 2442 W1782117679.pdf 4 10 text 0.9996747 "Quando comparados os valores de microdureza do cimento resinoso dual polimerizado sob a cerâmica à base de dissilicato de lítio e do grupo controle, foi possível concluir que a intensidade de luz não afetou a dureza do cimento. Diferenças estatísticas puderam ser encontradas apenas quando comparada a influência das diferentes intensidades de luz sob a mesma cerâmica. Os resultados mostraram que quando o cimento resinoso dual é polimerizado sob a cerâmica à base de dissilicato de lítio a uma intensidade de 1.000 mW/cm2, maiores valores de dureza são obtidos quando comparados à utilização de uma fonte de luz visível de intensidade de 800 mW/cm2; comprova-se, portanto, o fato de que dispositivos com baixa irradiância podem produzir resultados diferentes13." 2442 3239 W1782117679.pdf 4 11 separator 0.95117766 ¶ 3240 3242 W1782117679.pdf 4 12 text 0.9996652 "Da mesma forma, o uso de altas densidades de energia não está diretamente ligado a um maior grau de conversão3. De acordo com Heffernan et al.18,19, a translucidez da cerâmica tem influência direta da espessura do material e da sua composição cristalina." 3242 3506 W1782117679.pdf 4 13 separator 0.95078576 ¶ 3507 3509 W1782117679.pdf 4 14 text 0.9996415 "A microestrutura do material cerâmico, especialmente a sua fase cristalina, pode ter influenciado no processo de polimerização do cimento resinoso subjacente pelas suas diferenças de transmitância e espalhamento da luz3. Nesse caso, pela alta translucidez dessa cerâmica, maior intensidade de luz não acarretará em maiores valores de microdureza do cimento, quando comparado aos demais grupos." 3509 3915 W1782117679.pdf 4 15 separator 0.95632696 ¶ 3915 3917 W1782117679.pdf 4 16 text 0.99921995 "Os protocolos de polimerização utilizados no presente estudo também devem ser discutidos e os resultados comparados. Para o preparo das amostras, duas unidades de luz visível foram utilizadas." 3917 4116 W1782117679.pdf 4 17 separator 0.9382243 ¶ 4117 4119 W1782117679.pdf 4 18 text 0.99963325 "De acordo com o fabricante, o aparelho Radii-call (SDI) apresenta uma intensidade de luz extremamente alta (1.200 mW/cm2) e emissão espectral na faixa de 440-480 nm. Por outro lado, o aparelho Poly Wireless (Kavo) emite potência efetiva luminosa de 1.100 mW/cm2 e emissão espectral na faixa de 420-480 nm." 4119 4437 W1782117679.pdf 4 19 separator 0.9433361 ¶ 4437 4439 W1782117679.pdf 4 20 text 0.99970967 "Durante todo o experimento, a intensidade de luz de ambos os aparelhos foi medida com o auxílio de radiômetro Demetron (West Collins, Orange). Para o Radii-cal, o radiômetro empregado registrou uma intensidade de luz máxima de 800 mW/cm2. Todavia, para o Poly Wireless (Kavo), a intensidade registrada máxima foi de 1.000 mW/cm2. Para ambos os aparelhos, o registro máximo de intensidade luminosa ocorreu durante os primeiros 15 segundos de polimerização, não se estendendo até ao final do ciclo luminoso da fonte de luz. Pelo tempo restante, toda a intensidade de luz monitorada se manteve em 400 mW/cm2, o que pode ter justificado a pouca diferença significativa entre os grupos investigados." 4439 5164 W1782117679.pdf 4 21 separator 0.9399938 ¶ 5165 5167 W1782117679.pdf 4 22 text 0.9996016 "Esse fator, associado à opacidade das cerâmicas, poderia ter reduzido o grau de conversão do cimento resinoso estudado, resultando em valores de microdureza menores quando polimerizados pelo aparelho de luz visível de menor intensidade (800 mW/cm2)." 5167 5426 W1782117679.pdf 4 23 separator 0.9414579 ¶ 5426 5428 W1782117679.pdf 4 24 text 0.99963236 "Esta pesquisa gera novas questões a serem investigadas, como, por exemplo: ‘ A variação no tempo de fotopolimerização pode aumentar de forma significativa os valores de microdureza das amostras de cimento investigada?’ . Além disso: ‘O valor de microdureza de materiais resinosos poderá aumentar significativamente quando novos aparelhos fotopolimerizadores de potência elevada forem utilizados?’ . Diante de novas indagações, estudos direcionados para os cimentos resinosos com aparelhos com intensidades elevadas passam a ser foco de novas investigações científicas." 5428 6021 W1782117679.pdf 4 25 separator 0.99028647 ¶ 6021 6023 W1782117679.pdf 4 26 title 0.9880161 CONCLUSÃO 6023 6033 W1782117679.pdf 4 27 separator 0.99593437 ¶ 6033 6035 W1782117679.pdf 4 28 text 0.9997011 "De acordo com metodologia empregada no presente estudo, pode-se concluir que a polimerização do cimento resinoso dual é significativamente afetada pelo tipo de barreira cerâmica e pela intensidade de luz. Maior intensidade de luz do fotopolimerizador (1.000 mW/cm2) resultou em maiores valores de microdureza do cimento resinoso dual para as cerâmicas à base de zircônia e espinélio MgAl2O4. O cimento resinoso dual apresentou menor valor de microdureza na presença da cerâmica à base de dissilicato de lítio, sugerindo que este tipo de cerâmica pode ser considerada uma barreira maior para a passagem da luz e consequente polimerização do cimento. Para o aparelho fotopolimerizador de 800 mW/cm2, a presença das cerâmicas determinou valores de microdureza significativamente menores para as cerâmicas à base de zircônia e espinélio MgAl2O4." 6035 6916 W1782117679.pdf 4 0 paratext 0.9858019 ISSN 2307–3489 (Print), ȱSSN 2307–6666 (Online) 0 47 W2032068880.pdf 3 1 separator 0.9835953 ¶ 48 50 W2032068880.pdf 3 2 title 0.9426207 ɇɚɭɤɚ ɬɚ ɩɪɨɝɪɟɫ ɬɪɚɧɫɩɨɪɬɭ . 52 85 W2032068880.pdf 3 3 paratext 0.5036746 ȼ 85 87 W2032068880.pdf 3 4 title 0.48702493 ɿɫɧ 87 90 W2032068880.pdf 3 5 paratext 0.46207458 ɢɤ 90 92 W2032068880.pdf 3 6 title 0.5217485 Ⱦɧɿɩɪɨɩɟɬɪɨɜɫɶɤɨ 93 110 W2032068880.pdf 3 7 paratext 0.57099515 "ɝɨ ɧɚɰɿɨɧɚɥɶɧɨɝɨ ɭɧɿɜɟɪɫɢɬɟɬɭ ɡɚɥɿɡɧɢɱɧɨɝɨ ɬɪɚɧɫɩɨɪɬɭ , 2013, ɜɢɩ . 1 (43)" 110 192 W2032068880.pdf 3 8 separator 0.9363115 ¶ ¶ 193 199 W2032068880.pdf 3 9 math 0.3346913 199 200 W2032068880.pdf 3 10 text 0.27900758 ȺȼɌɈɆȺɌɂɁɈȼȺ 200 212 W2032068880.pdf 3 11 paratext 0.24227996 ɇȱ 212 216 W2032068880.pdf 3 12 text 0.28217936 ɋɂɋ 216 219 W2032068880.pdf 3 13 math 0.2850862 ɌȿɆɂ 219 223 W2032068880.pdf 3 14 paratext 0.22387242 224 225 W2032068880.pdf 3 15 text 0.89406973 "ɍɉɊȺȼɅȱɇɇə ɇȺ ɌɊȺɇɋɉɈɊɌȱ © Ʉ. ȼ. Ƚɨɧɱɚɪɨɜ , 2013 ɥɨɤɨɦɨɬɢɜɧɵɣ ɩɪɢɟɦɧɢɤ ɞɨɥɠɟɧ ɭɫɬɚɧɨɜɢɬɶ ɦɚɤ - ɫɢɦɚɥɶɧɨ ɩɪɚɜɢɥɶɧɨɟ ɪɟɲɟɧɢɟ DP ɩɪɢ ɡɚɞɚɧɧɨɣ ɜɟɪɨɹɬɧɨɫɬɢ ɨɩɚɫɧɨɣ ɨɲɢɛɤɢ II P. ɂɧɵɦɢ ɫɥɨɜɚ - ɦɢ ɩɪɢɟɦɧɢɤ ɞɨɥɠɟɧ ɨɛɟɫɩɟɱɢɜɚɬɶ ɤɚɤ ɦɨɠɧɨ ɥɭɱɲɭɸ ɩɨɦɟɯɨɭɫɬɨɣɱɢɜɨɫɬɶ ɩɪɢ ɡɚɞɚɧɧɨɦ ɭɪɨɜɧɟ ɮɭɧɤɰɢɨɧɚɥɶɧɨɣ ɛɟɡɨɩɚɫɧɨɫɬɢ ." 225 573 W2032068880.pdf 3 16 separator 0.9894991 ¶ 574 576 W2032068880.pdf 3 17 title 0.9751181 Ⱥɥɝɨɪɢɬɦ ɨɛɧɚɪɭɠɟɧɢɹ ɫɢɝɧɚɥɚ ȺɅɋɇ 576 613 W2032068880.pdf 3 18 separator 0.8374373 ¶ 615 617 W2032068880.pdf 3 19 text 0.9914129 "Ʌɨɤɨɦɨɬɢɜɧɵɣ ɩɪɢɟɦɧɢɤ ɜɵɩɨɥɧɹɟɬ ɨɛɧɚ - ɪɭɠɟɧɢɟ ɧɚ ɮɨɧɟ ɩɨɦɟɯ ɨɞɧɨɝɨ ɢɡ ɫɢɝɧɚɥɨɜ" 617 708 W2032068880.pdf 3 20 separator 0.7171602 ¶ 710 712 W2032068880.pdf 3 21 math 0.6057091 ȺɅɋɇ ɜ 712 720 W2032068880.pdf 3 22 text 0.46941477 ɢ 720 721 W2032068880.pdf 3 23 math 0.47928953 ɞ 721 722 W2032068880.pdf 3 24 text 0.46702865 ɚ 722 723 W2032068880.pdf 3 25 math 0.8926884 ": ɰ 0( , ) ( )cos( ) N i i i i i js t A t jT t O K W Z M ¦ , (5) ¶" 723 813 W2032068880.pdf 3 26 text 0.7123864 "ɝɞɟ Z – ɱɚɫɬɨɬɚ ɫɢɝɧɚɥɚ ; N – ɤɨɥɢɱɟɫɬɜɨ ɰɢɤ - ɥɨɜ ɧɚ ɢɧɬɟɪɜɚɥɟ ɧɚɛɥɸɞɟɧɢɹ ; ɰT – ɞɥɢɬɟɥɶ - ɧɨɫɬɶ ɰɢɤɥɚ " 813 929 W2032068880.pdf 3 27 math 0.58321387 ; ɰ ( ) i i t jT K W – ɧ 929 958 W2032068880.pdf 3 28 text 0.48723292 ɨɪɦɢɪ 958 963 W2032068880.pdf 3 29 math 0.4613877 ɨ 963 964 W2032068880.pdf 3 30 text 0.48353395 ɜɚɧɧ 964 968 W2032068880.pdf 3 31 math 0.5287438 "ɚɹ ɨɝɢɛɚɸ" 968 981 W2032068880.pdf 3 32 text 0.48472896 ɳɚɹ 981 984 W2032068880.pdf 3 33 math 0.5022226 ɫɢɝɧ 985 990 W2032068880.pdf 3 34 text 0.604807 "ɚɥɚ ȺɅɋɇ , ɩɪɢɧɢɦɚɸɳɚɹ ɡɧɚ - ɱɟɧɢɹ ɧɨɥɶ ɢɥɢ ɟɞɢɧɢɰɚ . ɇɚɩɪɢɦɟɪ , ɞɥɹ ɤɨɞɚ «ɀ», ɫɨɞɟɪɠɚɳɟɝɨ ɞɜɚ ɢɦɩɭɥɶɫɚ ɜ ɰɢɤɥɟ" 990 1116 W2032068880.pdf 3 35 math 0.93169075 "¶ ɢɠ ɢɠ ɢɠ ɩɠ 2 ɢɠ ɩɠ ɢɠ ɩɠ ɢɠ ɩɠ ɰ 1, 0 0, ( ) 1, 2 0, 2 t t t t t t tt t t t t t t t T Kd ­ °d ° ® d ° ° d ̄, (6) ¶" 1118 1283 W2032068880.pdf 3 36 text 0.8583711 "ɝɞɟ ɢɠ t ɢ ɩɠ t – ɞɥɢɬɟɥɶɧɨɫɬɶ ɢɦɩɭɥɶɫɨɜ ɢ ɩɚɭ - ɡɵ ɜ ɤɨɞɟ « ɀ». Ⱥɧɚɥɨɝɢɱɧɨ ɦɨɠɧɨ ɨɩɢɫɚɬɶ ɨɝɢɛɚɸɳɭɸ ɞɪɭɝɢɯ ɤɨɞɨɜɵɯ ɫɢɝɧɚɥɨɜ ." 1283 1425 W2032068880.pdf 3 37 separator 0.8919921 ¶ 1426 1428 W2032068880.pdf 3 38 text 0.98285127 "Ɍɚɤ ɤɚɤ ɫɢɝɧɚɥɵ ȺɅɋɇ ɩɟɪɢɨɞɢɱɟɫɤɢɟ , ɬɨ ɞɨɫɬɚɬɨɱɧɨ ɩɪɨɚɧɚɥɢɡɢɪɨɜɚɬɶ ɬɨɥɶɤɨ ɨɞɢɧ ɩɟ - ɪɢɨɞ ɬɚɤɢɯ ɫɢɝɧɚɥɨɜ" 1428 1549 W2032068880.pdf 3 39 separator 0.44099212 ¶ 1551 1553 W2032068880.pdf 3 40 math 0.943365 ) cos( ) ( ) , (i i i i i t t A t s MZ W K O . (7) 1554 1610 W2032068880.pdf 3 41 separator 0.96195143 ¶ 1611 1613 W2032068880.pdf 3 42 text 0.5555707 ɋɬɟɩɟɧɶ 1613 1621 W2032068880.pdf 3 43 title 0.5846014 ɩɪɚɜɞɨɩɨɞɨɛ 1622 1634 W2032068880.pdf 3 44 text 0.84696484 "ɢɹ ɬɨɣ ɢɥɢ ɢɧɨɣ ɝɢɩɨ - ɬɟɡɵ ɨɩɪɟɞɟɥɹɟɬɫɹ ɟɟ ɚɩɨɫɬɟɪɢɨɪɧɨɣ ɜɟɪɨɹɬɧɨ - ɫɬɶɸ [8]" 1634 1724 W2032068880.pdf 3 45 separator 0.48110878 1725 1726 W2032068880.pdf 3 46 math 0.7453243 "¶ ) ( ) ( ) ( )(0 0 iT i pr T i i ps H PH kP HP HP [ [ , (8) ɝɞɟ T 0[ – ɪɟɚɥɢɡɚɰɢɹ ɜɯɨɞɧɨɝɨ ɫɢɝɧɚɥɚ ɩɪɢɟɦ - ɧɢɤɚ ɧɚ ɢɧɬɟɪɜɚɥɟ [0, ] T; ) (i pr HP – ɚɩɪɢɨɪɧɚɹ ɜɟɪɨɹɬɧɨɫɬɶ ɝɢɩɨɬɟɡɵ iH; ) ( )(0 iT i H P HL [ – ɮɭɧɤɰɢɹ ɩɪɚɜɞɨɩɨɞɨɛɢɹ ɝɢɩɨɬɟɡɵ iH." 1726 2003 W2032068880.pdf 3 47 text 0.92485136 "Ʉɨɷɮ - ɮɢɰɢɟɧɬ k ɨɩɪɟɞɟɥɹɟɬɫɹ ɢɡ ɭɫɥɨɜɢɹ ɧɨɪɦɢɪɨɜ - ɤɢ . Ɋɟɲɟɧɢɟ ɨ ɧɚɥɢɱɢɢ ɫɢɝɧɚɥɚ is ɩɪɢɧɢɦɚɟɬɫɹ , ɟɫɥɢ ɜɵɩɨɥɧɹɟɬɫɹ ɭɫɥɨɜɢɟ" 2003 2141 W2032068880.pdf 3 48 math 0.8587105 ¶ ) ( )(0HP HPps i ps ! . (9) 2143 2174 W2032068880.pdf 3 49 separator 0.9497659 ¶ 2175 2177 W2032068880.pdf 3 50 text 0.8335895 ɇɚ 2177 2180 W2032068880.pdf 3 51 title 0.49251825 ɪ 2181 2183 W2032068880.pdf 3 52 text 0.60514957 ɚɛɨɬɭ 2183 2188 W2032068880.pdf 3 53 title 0.6134642 ɥɨɤɨɦɨɬɢɜɧɨ 2189 2201 W2032068880.pdf 3 54 text 0.5139528 ɣ 2201 2202 W2032068880.pdf 3 55 title 0.657351 ɫɢɝɧɚɥɢɡɚ 2203 2213 W2032068880.pdf 3 56 text 0.97601 "ɰɢɢ ɧɚɢ - ɛɨɥɟɟ ɫɢɥɶɧɨɟ ɜɥɢɹɧɢɟ ɨɤɚɡɵɜɚɸɬ ɲɢɪɨɤɨɩɨ - ɥɨɫɧɵɟ ɢɦɩɭɥɶɫɧɵɟ ɩɨɦɟɯɢ [1]. ɉɨɷɬɨɦɭ ɜ ɤɚ - ɱɟɫɬɜɟ ɦɨɞɟɥɢ ɚɞɞɢɬɢɜɧɨɣ ɩɨɦɟɯɢ ( ) n t ɜɵɛɟ - ɪɟɦ ɛɟɥɵɣ ɝɚɭɫɫɨɜɫɤɢɣ ɲɭɦ ɫɨ ɫɩɟɤɬɪɚɥɶɧɨɣ ɩɥɨɬɧɨɫɬɶɸ N. ȼ ɷɬɨɦ ɫɥɭɱɚɟ ɮɭɧɤɰɢɹ ɩɪɚɜ - ɞɨɩɨɞɨɛɢɹ ɞɥɹ ɝɢɩɨɬɟɡɵ 0H ɪɚɜɧɹɟɬɫɹ [8]:" 2213 2524 W2032068880.pdf 3 57 separator 0.87625724 ¶ ¶ 2525 2531 W2032068880.pdf 3 58 math 0.9578039 "°¿°3⁄41⁄2 ° ̄°®­ 3T dt tNHL 02 0 ) (1exp )( [ . (10)" 2531 2592 W2032068880.pdf 3 59 separator 0.94161546 ¶ 2593 2595 W2032068880.pdf 3 60 text 0.831196 "Ɏɭɧɤɰɢɹ ɩɪɚɜɞɨɩɨɞɨɛɢɹ ɞɥɹ ɝɢɩɨɬɟɡɵ iH ɨɩ - ɪɟɞɟɥɹɟɬɫɹ ɜɵɪɚɠɟɧɢɟɦ [8]:" 2595 2673 W2032068880.pdf 3 61 separator 0.72719306 ¶ ¶ 2674 2684 W2032068880.pdf 3 62 math 0.9596375 "°¿°3⁄41⁄2 ° ̄°®­ 3T i dt t s tNHL 02) , ( ) (1exp )( O [ . (11)" 2684 2756 W2032068880.pdf 3 63 separator 0.9514214 ¶ 2757 2759 W2032068880.pdf 3 64 text 0.70910364 "ɗɧɟɪɝɢɹ ɫɢɝɧɚɥɚ ȺɅɋ ɧɚ ɢɧɬɟɪɜɚɥɟ ɧɚɛɥɸ - ɞɟɧɢɹ [0, ] T ɪɚɜɧɹɟɬɫɹ" 2759 2832 W2032068880.pdf 3 65 separator 0.63305146 ¶ 2834 2836 W2032068880.pdf 3 66 math 0.93399537 "3 T i i iiAdt ts E 02 2 2) , (DO , (12)" 2837 2888 W2032068880.pdf 3 67 separator 0.5256443 ¶ 2889 2891 W2032068880.pdf 3 68 text 0.8174599 "ɝɞɟ iD – ɷɤɜɢɜɚɥɟɧɬɧɚɹ ɞɥɢɬɟɥɶɧɨɫɬɶ ɫɢɝɧɚɥɚ ȺɅɋɇ ɧɚ ɢɧɬɟɪɜɚɥɟ [0, ] T. ɋ ɭɱɟɬɨɦ ɷɬɨɝɨ ɩɨ - ɥɭɱɢɦ" 2891 3002 W2032068880.pdf 3 69 separator 0.5827204 ¶ 3004 3006 W2032068880.pdf 3 70 math 0.962726 "2 01( ) exp ( ) T iL H t dt N[­ 1⁄2 ° ° u ® 3⁄4 ° ° ̄ ¿ 3 ¶ 02exp ( ) ( , ) T iEt s t dt N N [ O ­ 1⁄2 ° °u ® 3⁄4 ° ° ̄ ¿ 3. (13)" 3007 3150 W2032068880.pdf 3 71 separator 0.97638506 ¶ 3151 3153 W2032068880.pdf 3 72 text 0.86966896 "ɉɨɞɫɬɚɜɥɹɹ ɜɵɪɚɠɟɧɢɹ (10), (13) ɜ (8), (9), ɩɨ - ɫɥɟ ɭɩɪɨɳɟɧɢɹ ɩɨɥɭɱɢɦ ɭɫɥɨɜɢɟ ɨɛɧɚɪɭɠɟɧɢɹ ɫɢɝɧɚɥɚ is" 3153 3268 W2032068880.pdf 3 73 separator 0.49318522 ¶ 3269 3271 W2032068880.pdf 3 74 math 0.94394 "3 ̧ ̧ 1· ̈ ̈ ©§ ! T ii i pr pr i i i hE HPHP Ndt t s t q 00 2 )()(ln 2), ( ) (O [ .(14)" 3271 3380 W2032068880.pdf 3 75 separator 0.9574803 ¶ 3381 3383 W2032068880.pdf 3 76 text 0.9910913 "Ɍɚɤɢɦ ɨɛɪɚɡɨɦ , ɜ ɥɨɤɨɦɨɬɢɜɧɨɦ ɩɪɢɟɦɧɢɤɟ ɞɨɥɠɧɚ ɜɵɱɢɫɥɹɬɶɫɹ ɜɡɚɢɦɧɚɹ ɤɨɪɪɟɥɹɰɢɹ iq ɩɪɢɧɹɬɨɝɨ ɤɨɥɟɛɚɧɢɹ ) (t[ ɢ ɨɛɪɚɡɰɨɜɨɝɨ ɫɢɝ - ɧɚɥɚ is. ȿɫɥɢ iq ɩɪɟɜɵɲɚɟɬ ɩɨɪɨɝɨɜɵɣ ɭɪɨɜɟɧɶ" 3383 3579 W2032068880.pdf 3 77 separator 0.9541364 ¶ 3581 3583 W2032068880.pdf 3 78 math 0.48392507 33 3583 3586 W2032068880.pdf 3 0 text 0.9994987 "because they cannot be accurately differentiated [18]. Women are often reluctant to disclose attempted induced abortion and it is not always documented in medical charts, especially in an illegal context [19]. Health complications from spontaneous abortion arelikely to remain relatively constant in the population, whereasthose arising from induced abortion should decline with safer caresince sepsis and injuries are primarily due to unsafe inducedabortion procedures. We assessed the proportion of seriousabortion complications relative to all abortion complicationspresenting to help account for secular trends in fertility, healthcare use, and abortion, and to test whether a shift toward less serious health complications would occur following abortion legalization. To check our results, we also analyzed the outcomeof proportion of serious abortion complication relative to livebirths over the time period." 0 924 W1965360155.pdf 2 1 separator 0.9906743 ¶ 924 926 W1965360155.pdf 2 2 text 0.99947804 "We adapted a categorization scheme proposed by others to code the severity of complications using clinical signs and symptoms to distinguish between uncomplicated incomplete abortion cases and those with more serious health implications [20]. Our approachdiffered only slightly: we did not code cases with any sign ofinterference as high severity, and we did not attempt to distinguishbetween low and medium severity cases. Higher severity cases ofinfection, injury, or systemic complications have recordedtemperature of 102 uF or above, a pulse of 120 beats per minute or more, septic shock or septicemia, hypovolemic shock, gener-alized and local peritonitis, endometritis, pelvic or genital tract infection, a retained foreign body or injury from abortion, organ failure, loss of consciousness, or death. A separate variable wasconstructed to identify cases where induced abortion was explicitlydocumented in the medical chart." 926 1869 W1965360155.pdf 2 3 separator 0.99683535 ¶ 1869 1871 W1965360155.pdf 2 4 title 0.9327135 Analysis 1871 1880 W1965360155.pdf 2 5 separator 0.99270535 ¶ 1880 1882 W1965360155.pdf 2 6 text 0.9994989 "Complications during three periods were described with counts and frequencies: before implementation (2001–2003), earlyimplementation (2004–2006), and later implementation (2007–2010). Types of complications were compared across the threetime periods with the Fisher Exact test for categorical differences.Tests for trend for each phase were conducted using segmented Poisson regression with flexible splines fit to the time periods [21,22]. Count of cases per month is the dependent variable withtime as an independent variable representing the incidence-rateratio (IRR) with the natural log of total cases as an offset variable.We used splines to test the trend in slope for each time period.Marginal splines were used to compare changes in the rate ofincrease or decrease from the previous period. Multiple variablelogistic regression models were also used to estimate the odds of aserious abortion complication by time period, adjusted for and testing the odds of risk by stage of pregnancy at admission, patient age, and whether induced abortion was documented in themedical chart. We also assessed the odds of sepsis, the mostcommon complication of unsafe abortion, by these factors. Themultivariable logistic regression models were also adjusted forseason (spring, summer, winter, fall) and hospital. Logistic modelsestimated only on the documented induced abortion cases werealso tested to check if results were consistent with the mainfindings." 1882 3346 W1965360155.pdf 2 7 separator 0.99704313 ¶ 3346 3348 W1965360155.pdf 2 8 title 0.92780155 Results 3348 3356 W1965360155.pdf 2 9 separator 0.9945711 ¶ 3356 3358 W1965360155.pdf 2 10 text 0.99963737 "Of 24,676 cases abstracted, 23,493 cases of abortion compli- cations were included in the final analytic sample; 16,499 caseswere from MH, 3,135 cases were from LZN, 2,952 were fromBDH, and 907 cases were from TUTH. The mean age of thewomen presenting with abortion complications was 25.4(SD = 6.1), and nearly all were married (Table 1). Nearly one- third of women were nulliparous, and over one-third had had two or more births. Induced abortion was documented in the medical chart in 9.6% of cases overall, and higher (11.5%) during laterimplementation." 3358 3923 W1965360155.pdf 2 11 separator 0.98998845 ¶ 3923 3925 W1965360155.pdf 2 12 text 0.9993085 "From 2001 to 2010 the number of abortion complications presenting at hospitals rose, ranging from a low of 2,120 in 2002 to a high of 2,948 in 2010. This is consistent with a secular increasein health care use occurring over the time period, particularly inthe most recent years when no-cost services at government clinicswere instituted [23]. A review of total hospital admissions, livebirths, and gynecological admissions at the hospitals also reflects this increase in health care use. At MH, for example, in 2001 there were 21,957 admissions and in 2010 there were 29,312admissions. The mean proportion of gynecological cases thatwere abortion-related remained stable over time (0.45, 95% CI0.44, 0.46)." 3925 4641 W1965360155.pdf 2 13 separator 0.99176455 ¶ 4641 4643 W1965360155.pdf 2 14 text 0.99270254 "The overall proportion of serious abortion complications relative to all complications was lowest in the later implementationperiod. Figure 1 illustrates the emergence of a decline in 2007 thatsteepens after 2008. An increasing trend in all serious complica-tions was observed during early implementation, whereas a significant decrease occurs in the later period (p ,.001). There" 4643 5028 W1965360155.pdf 2 15 title 0.6847543 Table 1. Characteristics of patients abstracted from medical 5028 5089 W1965360155.pdf 2 16 table 0.50814724 ¶ 5089 5090 W1965360155.pdf 2 17 title 0.5690694 charts for all 5090 5105 W1965360155.pdf 2 18 table 0.48252642 abort 5105 5111 W1965360155.pdf 2 19 title 0.51711345 ion 5111 5115 W1965360155.pdf 2 20 table 0.9808824 "complication cases, 2001–2010, N = 23,493. Characteristic Totala Mean age (SD) 25.4 (6.1) n = 23,471 Unmarried (%) 0.6n = 22,247 Mean years married (SD) 5.7 (6.0) n = 16,046Religion (%): n = 18,466 Hindu 96.5Non-Hindu 3.5 tNumber of births (%): n = 17,744 b None 32.2 One 32.0 Two or more 35.8 Gestation on admission (%): n = 21,713 4–2 weeks 73.913–18 weeks 16.1 19–28 weeks 10.0 Induced abortion (%) c9.6 n = 23,493" 5115 5576 W1965360155.pdf 2 21 separator 0.8103343 ¶ 5576 5578 W1965360155.pdf 2 22 text 0.8580266 "aInformation on patient demographics was not consistently available in the medical chart. The percentages are calculated on the non-missing n. bMissing data on the number of births increased at MH and TUTH, and declined at BDH and LZH. cClinical evidence such as foreign body or injury from instrumentation (e.g., uterine perforation) or free-text chart documentation of induced abortionbased upon patient disclosure or provider observation." 5578 6030 W1965360155.pdf 2 23 separator 0.9686496 ¶ 6030 6032 W1965360155.pdf 2 24 paratext 0.92870826 doi:10.1371/journal.pone.0064775.t001Effects 6032 6077 W1965360155.pdf 2 25 title 0.6873773 Abortion Legalization in 6077 6102 W1965360155.pdf 2 26 paratext 0.5322046 Nepal 6102 6108 W1965360155.pdf 2 27 separator 0.89447445 ¶ 6108 6110 W1965360155.pdf 2 28 paratext 0.9831153 PLOS ONE | www.plosone.org 3 May 2013 | Volume 8 | Issue 5 | e64775 6110 6178 W1965360155.pdf 2 0 bibliography 0.74365616 [2] 0 4 W3107475598.pdf 3 1 separator 0.4935976 ¶ 4 5 W3107475598.pdf 3 2 bibliography 0.9914637 "RFC6241: 'Network Configuration Protocol ¶ ¶ ¶ (NETCONF)', 2011." 5 92 W3107475598.pdf 3 3 separator 0.56500316 ¶ 92 94 W3107475598.pdf 3 4 bibliography 0.59650826 96 97 W3107475598.pdf 3 5 separator 0.59995395 ¶ 97 98 W3107475598.pdf 3 6 bibliography 0.9493435 "[3] RFC6020: 'YANG - A Data Modeling Language ¶ ¶ ¶ ¶ for the Network Configuration Protocol (NETCONF)', ¶ ¶ ¶ 2015." 98 285 W3107475598.pdf 3 7 separator 0.7973144 ¶ ¶ 285 291 W3107475598.pdf 3 8 bibliography 0.96991926 "[4] 'Open Config: Vendor-neutral, model-driven ¶ ¶ ¶ network management designed by users', ¶ ¶ ¶ http://openconfig.net/, accessed 6 May 2019." 291 482 W3107475598.pdf 3 9 separator 0.737313 ¶ 482 484 W3107475598.pdf 3 10 bibliography 0.49200416 486 487 W3107475598.pdf 3 11 separator 0.6099159 ¶ 487 488 W3107475598.pdf 3 12 bibliography 0.96539724 "[5] 'Disaggregated Transponder Chip Transport ¶ ¶ ¶ Abstraction Interface', ¶ https://github.com/Telecominfraproject/oopt-tai, ¶ Accessed 6 May 2019. " 488 677 W3107475598.pdf 3 13 separator 0.5438978 ¶ 677 678 W3107475598.pdf 3 14 bibliography 0.9822734 "¶ [6] ‘Atomix framework’, ¶ https://atomix.io/ ¶ [7] 'Open Transport Configuration & Control', ¶ ¶ ¶ https://wiki.opennetworking.org/display/OTCC/TAPI, ¶ Accessed 6 May, 2019." 680 899 W3107475598.pdf 3 15 separator 0.72017115 ¶ 899 901 W3107475598.pdf 3 16 bibliography 0.6179808 903 904 W3107475598.pdf 3 17 separator 0.55257154 ¶ 904 905 W3107475598.pdf 3 18 bibliography 0.89955115 "[8] RFC8040: 'RESTCONF Protocol', 2017. ¶ [9] A. Sgambelluri, J.-L. Izquierdo-Zaragoza, A. ¶ ¶ ¶ Giorgetti, et al ""Fully Disaggregated ROADM White ¶ " 905 1111 W3107475598.pdf 3 19 table 0.4199095 ¶ 1111 1112 W3107475598.pdf 3 20 bibliography 0.46244743 1114 1115 W3107475598.pdf 3 21 table 0.44475678 ¶ 1115 1116 W3107475598.pdf 3 22 bibliography 0.4707273 1118 1119 W3107475598.pdf 3 23 table 0.4488076 ¶ 1119 1120 W3107475598.pdf 3 24 bibliography 0.4998701 1122 1123 W3107475598.pdf 3 25 table 0.41948137 ¶ 1123 1124 W3107475598.pdf 3 26 bibliography 0.49783793 1126 1127 W3107475598.pdf 3 27 table 0.40431914 ¶ 1127 1128 W3107475598.pdf 3 28 bibliography 0.7809348 "Box with NETCONF/YANG Control, Telemetry, and ¶ ¶ ¶ Machine Learning-based Monitoring"" in Tech. Dig. ¶ ¶ ¶ OFC 2018." 1128 1305 W3107475598.pdf 3 29 separator 0.5962197 ¶ ¶ 1305 1311 W3107475598.pdf 3 30 paratext 0.89564717 4 1311 1313 W3107475598.pdf 3 31 separator 0.98122 ¶ 1313 1315 W3107475598.pdf 3 0 paratext 0.9758802 Open Peer Review on Qeios 0 25 W4234483640.pdf 0 1 separator 0.66648144 ¶ 25 27 W4234483640.pdf 0 2 paratext 0.930202 Open Peer Review on Qeios 27 53 W4234483640.pdf 0 3 separator 0.928038 ¶ 53 55 W4234483640.pdf 0 4 title 0.9644109 Carteolol Hydrochloride 55 79 W4234483640.pdf 0 5 separator 0.94269514 ¶ 79 81 W4234483640.pdf 0 6 title 0.8171785 National Cancer Institute 81 107 W4234483640.pdf 0 7 separator 0.9792868 ¶ 107 109 W4234483640.pdf 0 8 paratext 0.62380546 Source 109 116 W4234483640.pdf 0 9 separator 0.7540593 ¶ 116 118 W4234483640.pdf 0 10 paratext 0.4298261 National Cancer Institute. 118 145 W4234483640.pdf 0 11 separator 0.7920274 ¶ 146 148 W4234483640.pdf 0 12 paratext 0.41866183 Carteolol Hydrochloride 148 172 W4234483640.pdf 0 13 separator 0.38399154 ¶ 172 174 W4234483640.pdf 0 14 bibliography 0.4064626 174 175 W4234483640.pdf 0 15 paratext 0.40401116 . NCI Thesaurus 175 190 W4234483640.pdf 0 16 bibliography 0.41524106 . Code 190 196 W4234483640.pdf 0 17 paratext 0.37863493 C2 196 199 W4234483640.pdf 0 18 bibliography 0.35443342 8905. 199 204 W4234483640.pdf 0 19 separator 0.99321675 ¶ 204 206 W4234483640.pdf 0 20 text 0.99719256 "A synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)" 206 580 W4234483640.pdf 0 21 separator 0.981432 ¶ 580 582 W4234483640.pdf 0 22 paratext 0.9528688 "Qeios · Definition, February 7, 2020" 582 626 W4234483640.pdf 0 23 separator 0.5132864 626 627 W4234483640.pdf 0 24 paratext 0.9322038 "¶ Qeios ID: LADX2Y · https://doi.org/10.32388/LADX2Y 1 /" 627 691 W4234483640.pdf 0 25 separator 0.7543684 ¶ 691 693 W4234483640.pdf 0 26 paratext 0.72514296 1 693 695 W4234483640.pdf 0 0 paratext 0.9891838 Plant Methods 2009, 5:19 http://www.plantmethods.com/content/5/1/19 0 68 W2154966569.pdf 8 1 separator 0.6412637 ¶ 68 70 W2154966569.pdf 8 2 paratext 0.99088377 Page 9 of 11 70 83 W2154966569.pdf 8 3 separator 0.9853639 ¶ 83 85 W2154966569.pdf 8 4 text 0.9886482 "(page number not for citation purposes)urement of the reaction. On the contrary, enzyme activity resulting from strong/constitutive promoters allows high dilution of the extract, in which case the inhibitory capac-ity may become negligible and the measured activityexempt from artifacts. This finds experimental support inour experience with GUS assays performed on 35S-GUSArabidopsis leaf extracts: activity of the transgene can be efficiently measured by continuous monitoring even at a 1:1000 dilution of the extracts, where the concentration ofthe inhibitor is too low to interfere with the reaction(results not shown). Dilution of the extract may alsoexplain the absence of inhibitor reported by previousauthors in tobacco leaves [12,14]." 85 837 W2154966569.pdf 8 5 separator 0.9723685 ¶ 837 839 W2154966569.pdf 8 6 text 0.9997173 "Inhibitory capacity may vary among plant organs, yet the small variation found in our results suggests a consistentconcentration of inhibitors in each tissue. Thus far,improvements in the extraction procedure have aimed tolimit the effects of inhibitors by eliminating secondarycompounds through filtration [24] or inactivation with binding reagents (e.g. PVPP; [13]), but complete removal of the inhibitory capacity could not be achieved. In thisarticle we describe a simple and straightforward procedurethat allows to correct for enzyme inhibition independ-ently from the level of T-GUS activity present in the plantextract." 839 1472 W2154966569.pdf 8 7 separator 0.9747679 ¶ 1472 1474 W2154966569.pdf 8 8 text 0.99968433 "Owing to the ubiquitous presence of inhibitors in plant tissues, we strongly suggest that the presence of such com-pounds interfering in the GUS assay should be tested rou-tinely prior to each GUS assay. This can be easily achievedby measuring the enzymatic rate at two considerably dif- ferent concentrations of the extract, in order to verify the proportionality between the measured reaction rates andthe dilution factor. An enzymatic activity of the least con-centrated extract significantly higher than expected clearlyindicates the presence of inhibitors which interfere withthe measurement." 1474 2078 W2154966569.pdf 8 9 separator 0.9303261 ¶ 2078 2080 W2154966569.pdf 8 10 text 0.9996242 "Hence, in order to obtain reliable assays of T-GUS activity, the inhibitory capacity of the plant extract at the desiredconcentration should be determined and used to correctthe measured enzyme activity." 2080 2286 W2154966569.pdf 8 11 separator 0.8073379 ¶ 2286 2288 W2154966569.pdf 8 12 text 0.99915755 "This is easily achievable because of the same affinity of the plant extract inhibitors towards the enzyme encoded by the uidA gene (i.e. T-GUS) and the pure bacterial GUS, which allows to measure the inhibitory capacity of a tissueextract on the commercially available E. coli enzyme and apply the correction on the activity of the transgenicenzyme. This involves a straightforward procedure con- sisting of three steps that can be routinely applied to any assay: a) measurement of the T-GUS activity in the plantextract at convenient dilution; b) addition of a knownconcentration of commercial E. coli GUS to the plantextract and measurement of the overall enzymatic activity; c) measurement of the uninhibited activity of the same concentration of E. coli GUS in the extraction buffer. The E. coli GUS activity in the plant extract is calculated by sub- tracting the T-GUS activity from the overall enzymaticactivity. The inhibitory capacity is then calculated by com-parison of the uninhibited activity of the bacterial enzyme and its activity in the extract, and the inhibition percent- age is applied to correct the T-GUS reaction rates. It isimportant that the same extract concentration (i.e. theinhibitor concentration) is used when T-GUS activity ismeasured in the presence and absence of the added com-mercial E. coli GUS. Fluorescence coefficient of MU needs to be assessed in order to express enzyme activity in abso- lute values, thus correcting for fluorescence interference ofextract components. This applies regardless of the methodemployed to assay GUS activity, as we found that extractcomponents can bias results in both continuous and dis-continuous measurement (see [11])." 2288 4010 W2154966569.pdf 8 13 separator 0.985221 ¶ 4010 4012 W2154966569.pdf 8 14 text 0.9997529 "As the nature, localization and regulation of the com- pounds responsible for GUS inhibition are still unknown,it is difficult to hypothesize what variable factors mayaffect their concentration and extractability. Moreover,quantification of GUS activity is often performed in exper-iments carried out under variable physiological condi- tions, which may bear an unpredictable effect on the presence and activity of the inhibitor. For this reason,assuming that the inhibitory capacity calculated for a cer-tain organ is maintained constant in separate trials maylead to inaccurate results, and we strongly suggest that theinhibitor capacity is calculated for each single extract sam- ple at the desired dilution rather than applying values of correction calculated on separate, independent extracts ofthe same tissues." 4012 4840 W2154966569.pdf 8 15 separator 0.9960321 ¶ 4840 4842 W2154966569.pdf 8 16 title 0.9884976 Inhibition of plant endogenous GUS 4842 4877 W2154966569.pdf 8 17 separator 0.9936476 ¶ 4877 4879 W2154966569.pdf 8 18 text 0.9997674 "Endogenous GUS has recently been shown to be ubiqui- tous in plants [4], but its characterization is still poorly known. Combined with histochemical evidence comingfrom a large number of species, quantitative GUS assaysperformed on model plants have been used to study theactivity of the endogenous enzyme (e.g. [4,25-27]), andfurther investigations will allow to achieve a better under-standing of its function in plant organs." 4879 5312 W2154966569.pdf 8 19 separator 0.9195863 ¶ 5312 5314 W2154966569.pdf 8 20 text 0.99948806 "According to our results, inhibitory components present in tissue extracts affect also plant endogenous GUS,although with remarkably lower affinity as compared tothe E. coli enzyme. Similar disparity of inhibitory capacity towards plant endogenous GUS was previously reported for the commonly used inhibitor of E. coli GUS D-saccaric acid 1-4 lactone [24]." 5314 5679 W2154966569.pdf 8 0 separator 0.99432385 ¶ 1 2 W3168919676.pdf 4 1 caption 0.99601257 "Fig. 6. Detected Pu238-induced morphoses in F1 flies in test system 1-112: (a) shortened right wing; (b) change in thorax coloration or ""glazing"" (c ) absence of one wing with thorax deformation." 2 202 W3168919676.pdf 4 2 separator 0.98504615 ¶ 202 204 W3168919676.pdf 4 3 caption 0.77410567 "Morphoses in Drosophila flies of the first and seco nd generations appeared as black spots or melanomas on various parts of the imago body; ""generalized"" melanomas; twist" 204 378 W3168919676.pdf 4 4 text 0.50041956 ed 378 380 W3168919676.pdf 4 5 caption 0.5552704 , curved wings; 380 395 W3168919676.pdf 4 6 text 0.6064494 ¶ 396 398 W3168919676.pdf 4 7 caption 0.60148424 shortened 398 409 W3168919676.pdf 4 8 text 0.52885705 wing 409 413 W3168919676.pdf 4 9 caption 0.6284062 ; blister 413 422 W3168919676.pdf 4 10 text 0.53450716 ing 422 425 W3168919676.pdf 4 11 caption 0.5953595 on 425 428 W3168919676.pdf 4 12 text 0.48854077 one 428 433 W3168919676.pdf 4 13 caption 0.8110218 "wing; absence of one wing, deformation of thorax, interruption and violation of tergite patterns, violation of distribution of eye facets and hairs; pigmentation absence of second and third legs." 433 631 W3168919676.pdf 4 14 separator 0.9958271 ¶ 633 635 W3168919676.pdf 4 15 title 0.975221 4 Conclusion 635 648 W3168919676.pdf 4 16 separator 0.99587023 ¶ 648 650 W3168919676.pdf 4 17 text 0.99581146 "Statistical analysis by Chi-square method showed a significant differ ence in the mutation level in the experiment with Pu238 and the control at P≤0.01. Statistical analysis of data from the experiments with Ra226 and triplet significantly conf irmed the mutagenic effect at a probability level of P≤0.01. On the basis of this, it can be ass umed that alpha-particles which were used to simulate the situation in ra don-hazardous areas have a mutagenic effect manifested mainly in the formation of morphosis or deformities. " 650 1193 W3168919676.pdf 4 18 separator 0.50355595 ¶ 1193 1194 W3168919676.pdf 4 19 text 0.99187917 "The work was performed with the support of th e state grant funding of basic research of the Republic of Kazakhstan (AP09258978, AP09058404)." 1194 1339 W3168919676.pdf 4 20 separator 0.99622333 ¶ 1340 1342 W3168919676.pdf 4 21 title 0.60875416 References 1342 1353 W3168919676.pdf 4 22 separator 0.98879963 ¶ 1353 1355 W3168919676.pdf 4 23 bibliography 0.99600434 "1. ICRP Publication 65. Protection Against Radon- 222 at Home and at Work, Ann. ICRP 23(2) , 1-45 (1993)" 1355 1463 W3168919676.pdf 4 24 separator 0.8091464 ¶ 1464 1466 W3168919676.pdf 4 25 bibliography 0.994973 "2. ICRP Publication 50. Lung Cancer Risk from Exposures to Radon Daughters, Ann. ICRP 17(1) , 1-60 (1987)" 1466 1575 W3168919676.pdf 4 26 separator 0.982803 ¶ 1575 1577 W3168919676.pdf 4 27 bibliography 0.99798816 3.Z. Chen, Y. Li, Z. Liu, J. Wang, X. Zhou, J. Du, Sci Rep 8, 16772 (2018) 1577 1652 W3168919676.pdf 4 28 separator 0.76734126 ¶ 1652 1654 W3168919676.pdf 4 29 bibliography 0.9980238 "4. M. Neri, S. Giammanco, E. Ferrera, G. Patan e, V. Zanon, J. of Env. Radioactivity, 102(9) , 863–870 (2011)." 1654 1767 W3168919676.pdf 4 30 separator 0.8281579 ¶ 1768 1770 W3168919676.pdf 4 31 bibliography 0.99802995 5. J. Vaupotic, et al, Natural Hazards & Earth System Sciences, 10(4) , 1–6 (2010). 1770 1854 W3168919676.pdf 4 32 separator 0.84420574 ¶ 1854 1856 W3168919676.pdf 4 33 bibliography 0.9979073 6. A. Lovinskaya, et al., Ecological genetics, 17(2) , 69-81 (2019). 1856 1925 W3168919676.pdf 4 34 separator 0.9859773 ¶ 1925 1927 W3168919676.pdf 4 35 paratext 0.9747116 "E3S Web of Conferences 265, 02002 (2021) APEEM 2021https://doi.org/10.1051/e3sconf/202126502002" 1927 2025 W3168919676.pdf 4 36 separator 0.979889 ¶ 2025 2027 W3168919676.pdf 4 37 paratext 0.8907326 5 2027 2029 W3168919676.pdf 4 0 paratext 0.98551786 "RESEARCH ARTICLE European Journal of Law and Political Science www.ej -politics .org ¶ DOI: http://dx.doi.org/10.24018/ej politics .2023 .2.2.75 Vol 2 | Issue 2 | April 2023 37" 0 194 W4362639819.pdf 1 1 separator 0.9862863 ¶ 195 197 W4362639819.pdf 1 2 bibliography 0.84311116 "“Collecting Society Definition,” LexisNexis In -how Advisor expert, http://www. lexisnexis.co.uk , accessed on 6/2/2023)." 198 323 W4362639819.pdf 1 3 separator 0.99268126 ¶ 325 327 W4362639819.pdf 1 4 text 0.999227 "Furthermore, a collecting society is an organization that licenses and manages copyrighted works on behalf of copyright owners. Song writers and composers become members of collec ting societies to collect royalties from use of their works. Collecting societies monitor performances and distribution of the works, on radio, television, in public venues and online (Google, “About collecting societies”, http://www.support.google.com , accessed on 4/2/2023). The Copyright Act 2004 defines collecting society as an association of copyright owners which has as its principal objectives the negotiating and granting o f licenses , collecting, and distributing of royalties in respect of copyright work (S.39(8) of the Copyright Act Cap C28 Laws of the Federation of Nigeria 2004)." 327 1128 W4362639819.pdf 1 5 separator 0.9558011 ¶ 1130 1132 W4362639819.pdf 1 6 text 0.99864835 "Consequently, it is my considered opinion that collecting society is a non -governmental organ ization approved and registered by the Nigerian Copyright Commission for the protection of copyright works particularly, in the grant of licenses , collecting and distribution of royalties, and enforcement of copyright rights where need be." 1132 1477 W4362639819.pdf 1 7 separator 0.9928788 ¶ ¶ 1479 1485 W4362639819.pdf 1 8 title 0.9946781 III. FORMATION , APPROVAL AND REGISTRATION OF COLLECTING SOCIETY 1485 1550 W4362639819.pdf 1 9 separator 0.99621713 ¶ 1552 1554 W4362639819.pdf 1 10 text 0.9847546 "The formation of the collecting society is enshrined in Section 39 of the copyright Act 2004. Section 39(1) provides that a collecting society may be formed in respect of any one or more rights of copyright owners for the benefit of such owner, and the society may apply to the commission for approval to operate as a collecting society. The Copyright Act in showing the importance and necessity of the Nigerian Copyright Commission to approve any c ollecting society provides in S. 39(4) thus: ¶ “It shall be unlawful for any group of persons to purport to perform the duties of a society without the approval of the commission as required under this section. Failure to comply with the relevant provisions of the law regarding collecting societies, whether by individuals or corporate bodies constitutes a crime punishable by imprisonment or fine.” (S.39(5) and (6) of the Copyright Act 2004). ¶ Section 17 of the Copyright Act also provides that: ¶ “Notwithsta nding the provisions of this Act or any other law, no action for infringement of copyright or any right under this Act shall be commenced or maintained by any person – a) Carrying on the business of negotiating and granting of licence; b) Collecting and di stribution royalties in respect of copyright works or representing more than fifty owners of copyright in any category or works protected by this Act. Unless it is approved under Section 39 of this Act to operate as a collecting society or is otherwise iss ued a certificate of exemption by the commission. ”" 1554 3148 W4362639819.pdf 1 11 separator 0.7487744 ¶ ¶ 3150 3156 W4362639819.pdf 1 12 bibliography 0.9677311 See also Multichoice Nig Ltd v MSCN Nig Ltd/Gte (2020) 3156 3211 W4362639819.pdf 1 13 separator 0.99306333 ¶ 3213 3215 W4362639819.pdf 1 14 text 0.9979906 "The community reading of sections 17 and 39 of the Copyright Act 2004 is to the effect that a collecting society is formed in respect of rights of copyright owners and for their benefit and this society requires approval or certificate of exemption by the Nigerian Copyright Commission." 3215 3508 W4362639819.pdf 1 15 separator 0.9885428 ¶ 3510 3512 W4362639819.pdf 1 16 text 0.99512047 "In Nigerian Copyright Commission & Ors v Musical Copyright Society of Nigeria Ltd & Ors (2017), the Court of Appeal per B.A. Georgewill held that: ¶ “...In my finding the 1st Respondent and its Officers, Staff and or Agent, undoubtedly carrying on the functions of a collecting society required the approval of the Appellant to so operate as a collecting society in Nigeria, failing which their activities thereto are illegal. See Sections 16, 17 and 39 of the Copyright Act 2004.In law therefore, an Association of Copyright Owners, referred to as Collecting Society, which may be formed upon the satisfaction of the conditions provided for under the Act, requi re by law by virtue of Sections 17 and 39 of the Copyright Act the approval of the Copyright Commission to operate as Collecting Society in the first place, in which capacity only they could sue under the Copy Right Act and therefore, the approval of the N igeria Copyright Commission is a condition precedent to their operation as Collecting Society and without which they would lack the legal standing to sue under the Copy Right Act 2004, of which the 1st Respondent is undoubtedly a collecting society." 3512 4725 W4362639819.pdf 1 17 separator 0.9683161 ¶ 4727 4729 W4362639819.pdf 1 18 bibliography 0.9694409 "See S ection 39 of the Copyright Act 2004. See Compact Disc Technologies Ltd v. MCSN Ltd/Gte (2010) LPELR (CA) .”" 4729 4846 W4362639819.pdf 1 19 separator 0.92312026 ¶ ¶ 4847 4853 W4362639819.pdf 1 20 text 0.9973005 "Also the Court in Performing and Mechanical Right Society Ltd/Gte v Skye Bank & Ors (2017) in adumbration and support of the above, stated that the community purport of the provisions Sections 17" 4853 5053 W4362639819.pdf 1 0 paratext 0.8424884 Billon et al. Vitiligo in Renal Cell Carcinoma 0 46 W2979408602.pdf 3 1 separator 0.99584305 ¶ 46 48 W2979408602.pdf 3 2 caption 0.9948516 "FIGURE 2 | Vitiligo lesions. Depigmentation of eyebrows (A), hair(B), and skin(C)observed after 8 months of treatment with nivolumab. Depigm entation affected the whole skin but preferentially the chest." 48 256 W2979408602.pdf 3 3 separator 0.99145293 ¶ 256 258 W2979408602.pdf 3 4 caption 0.98396033 "FIGURE 3 | Macroscopic and microscopic examination. Macroscopic examination (A): fibrosis alterations on upper pole of the kidney (arrow) " 258 398 W2979408602.pdf 3 5 separator 0.5279072 ¶ 398 399 W2979408602.pdf 3 6 caption 0.9956492 "Microscopic examination (B,C): fibrosis alterations with calcifications and without residual tumor cells. Stars indicate normal parenc hyma." 399 540 W2979408602.pdf 3 7 separator 0.9927561 ¶ 540 542 W2979408602.pdf 3 8 text 0.99932975 "Certain HLA genotypes, such as HLA DQ2/DQ8 or HLA DQA1, might be associated with immune disorders ( 23) and could be consequently associated with irAEs ( 24) or tumor response to ICIs. However, these genotypes were not detected in our patient after HLA typing. Recent studies suggest that HLA expression may affect the response to immune checkpoint inhibitorsinadvancedmelanoma( 25)andHodgkin’slymphoma (26). Patients with MHC class II-positive and MHC class I-low expression tumors might have better responses and improvedOS." 542 1086 W2979408602.pdf 3 9 separator 0.9898585 ¶ 1086 1088 W2979408602.pdf 3 10 text 0.99765795 "The role of nephrectomy is still unclear for patients who have a complete response to nivolumab in renal cell carcinoma." 1088 1211 W2979408602.pdf 3 11 separator 0.6217682 ¶ 1211 1213 W2979408602.pdf 3 12 text 0.99951625 "Approximately 90% of patients in the Checkmate 025 trial had a prior nephrectomy before systemic therapy, yet only a few (1%) had a complete response to treatment ( 6). Two othercases of total nephrectomy after radiological complete respon se with nivolumab were also described ( 27,28), where both cases observed complete pathological responses without any viable malignant cells. These two cases, such as our, indicate that total nephrectomies could be safely carried out for metastat ic clearcell renal cell carcinoma afternivolumabtherapy,how ever, in our case, a partial nephrectomy was impossible due to significant post-immunotherapy fibrosis. Also, it is important to note that, in the case of pathological complete response, a biopsy is required before surgery in order to avoid an unnecessarynephrectomy." 1213 2050 W2979408602.pdf 3 13 separator 0.9837064 ¶ 2050 2052 W2979408602.pdf 3 14 text 0.9988516 "The question of nivolumab discontinuation remains unanswered in metastatic clear cell renal cell carcinoma for patients treated for 2 years with pathological complete respons e." 2052 2234 W2979408602.pdf 3 15 separator 0.9493137 ¶ 2234 2236 W2979408602.pdf 3 16 text 0.9996069 "In metastatic melanomas, retrospective and prospective data indicated excellent results with immune checkpoint inhibitor therapy, even after discontinuation. In the phase III Checkmate 067 study, 159/314 patients treated by the combination nivolumab +ipilimumab were still alive at 4 years, and 113 (71%) of them are free from study treatment and have never received subsequent systemic therapy ( 29)." 2236 2650 W2979408602.pdf 3 17 separator 0.88341296 ¶ 2650 2652 W2979408602.pdf 3 18 text 0.9996462 "For patients who received nivolumab alone, 138/316 patients were still alive after 4 years, and 69 stopped the treatment for any reason and never received other systemic therapy. In contrast, in the phase III Checkmate 017 and Checkmate 057 studies, 20/83 patients responding to nivolumab for non-smal l cell lung cancer maintained an objective response after 3 years (26/418 patients continued nivolumab at 3 years) ( 30)." 2652 3088 W2979408602.pdf 3 19 separator 0.95503217 ¶ 3088 3090 W2979408602.pdf 3 20 text 0.99969107 "Furthermore, in a retrospective study of 19 patients with non-small cell lung cancer responding to immune checkpoint inhibitor therapy, for those who stopped immune checkpoint inhibitor treatment due to AEs ( 31) the median PFS after discontinuation depended on the confirmed response during administration, as PFS was not reached for partial response patients (4/19) vs. 4.9 months for stable patients (12/19)." 3090 3513 W2979408602.pdf 3 21 separator 0.96918696 ¶ 3513 3515 W2979408602.pdf 3 22 text 0.9932614 "Additionally, in a retrospective analysis of 262 patients tre ated with immune checkpoint inhibitor therapy in phase I studies for all types of cancer, immunotherapy was discontinued in 39 cases for reasons other than progression, while 24 patients were still responding to treatment and 39 were in complete response( 32). Nivolumab discontinuation was not documented in mCCRCC, and the decision, in our case, was made in concert withthepatient." 3515 3977 W2979408602.pdf 3 23 separator 0.9954215 ¶ 3977 3979 W2979408602.pdf 3 24 title 0.98940724 CONCLUSION 3979 3990 W2979408602.pdf 3 25 separator 0.99494916 ¶ 3990 3992 W2979408602.pdf 3 26 text 0.9969072 "We reported herein a case of metastatic clear cell renal cell carcinoma with radiological and pathological complete response after nivolumab therapy and the associated irAEs. This case further highlights the potentially predictive role of irAEs during nivolumab therapy for mCCRCC. Further studies are needed to better identify predictive factors for treatment response to immunotherapy in metastatic renal cell carcinoma, and to better understand the role of nephrectomy afternivolumabtreatment." 3992 4505 W2979408602.pdf 3 27 separator 0.978421 ¶ 4505 4507 W2979408602.pdf 3 28 paratext 0.98452836 Frontiers in Oncology | www.frontiersin.org 4 October 2019 | Volume 9 | Article 1033 4507 4592 W2979408602.pdf 3 0 text 0.9997037 "Western Europe. In the second section, I argue that Christian privilege is embedded in a secular Christian hegemony. Despite national differences, many hegemonic Christiansymbols and practices across Europe are seen as ‘secular ’, made possible by a speci fically Christian understanding of ‘religion ’, alongside ‘culture ’and ‘secularity ’. I argue that this secular Christian hegemony facilitates discourses of racism and religious bigotry which portray non-Christians as abnormal and deviant Others, but it also has a complex and at times strained relationship with confessional forms of Christianity. This expands andcomplicates existing research that points to an anti-religious climate and the dominationof the secular (e.g. Cavanaugh, 2009 ;Hirschkind, 2011 ). In the third section, I explore concrete examples of Christian privilege and sketch a normative framework to furtherdemocratic debate about which kinds of Christian privilege are legitimate, and which arenot. Building on the work of Lawrence Blum (2008) , I differentiate between privileges as spared injustices, unjust enrichments, and justi fiable privileges. I also make some pre- liminary suggestions for addressing problematic forms of Christian privilege. Here, it becomes clear that simply demanding a stricter form of separating ‘religion ’from ‘secular ’realms does not provide a satisfactory solution." 0 1398 W4281755369.pdf 2 1 separator 0.99675155 ¶ 1398 1400 W4281755369.pdf 2 2 title 0.9924078 Privilege as analytic tool: Hegemony and privilege 1400 1451 W4281755369.pdf 2 3 separator 0.9955568 ¶ 1451 1453 W4281755369.pdf 2 4 text 0.9997646 "In the decades following Peggy McIntosh ’seminal article on privilege as ‘invisible knapsack ’of unearned bene fits in 1988, the conceptual language of ‘privilege ’has become widespread in activism as well as scholarship on race, gender, and class. The main aim of McIntosh ’article was to broaden our understanding of inequality by not just looking at disadvantages that result from it, but also by examining how some groupsbenefit from it. Bearers of privilege, McIntosh (1988) argued, are generally unaware of this, because they lack the social information to recognize the obstacles they do not experience. However, the lens of privilege has been criticized for focusing too much onindividual self-transformation and guilt, rather than structural analyses of oppression andexclusion ( Lensmire et al., 2013 ;Leonardo, 2004 ;McWhorter, 2005 ). The focus on raising awareness and ‘checking one ’s privileges ’, critics have rightly argued, has often led to an understanding of privilege as a psychological attitude that can be remedied bypersonal decisions, rather than a structural problem with psychological as well assymbolic and material repercussions ( Pease, 2010 ). This impedes a structural interro- gation of capitalism, patriarchy, and white supremacy ( Aouragh, 2019 ;Budgeon, 2015 )." 1453 2767 W4281755369.pdf 2 5 separator 0.9624945 ¶ 2767 2769 W4281755369.pdf 2 6 paratext 0.8961628 3 2769 2771 W4281755369.pdf 2 7 separator 0.99574697 ¶ 2771 2773 W4281755369.pdf 2 8 text 0.9976088 "To avoid such an individualizing approach to privilege, it is important to reconsider what role privilege can and should take up in the conceptual toolbox of analyzing powerhierarchies. I argue that the concept of privilege has most critical force when it is un- derstood as the concrete materialization of structures of hegemony. Popularized by Marxist scholar Antonio Gramsci and later often used in Foucauldian accounts of dis-cursive power, hegemony is a system of hierarchical power based on manufacturing akind of ‘common sense ’. Unlike direct domination or coercion, hegemony works via particular hierarchies embedded in dominant ideas, values, norms, beliefs, and prejudicesthat are produced as ‘normal ’through ‘societal expectation, peer pressure, propriety and at times politics of shame ’(Dhawan et al., 2016 : 3). Those whose behaviour orLauwers 405" 2773 3647 W4281755369.pdf 2 0 paratext 0.984977 Commente374 www.thelancet.com/planetary-health Vol 3 September 2019 0 72 W2974448360.pdf 2 1 text 0.9977971 "First, structured, systematic consultation with young people must guide work in planetary health. Leaders in planetary health need to establish clear, consistent, and safe opportunities for young people in agenda setting and decision making and provide support and resources for translating youth input into tangible outcomes. Dedicated youth ambassadors and advisory bodies are a potentially useful starting point. However, consulting select groups of young people is not an adequate substitute for engagement with a broad spectrum of youth perspectives. Planetary health leaders must therefore develop comprehensive youth consultation and engagement strategies to maximise the diversity of available youth expertise. These strategies should include deliberate effort to seek out marginalised groups, whose voices are often not heard." 72 913 W2974448360.pdf 2 2 separator 0.9665532 ¶ 913 915 W2974448360.pdf 2 3 text 0.9997291 "Second, as well as providing opportunities for young people to participate in planetary health, leaders must facilitate youth participation by identifying and removing barriers. Many of these barriers are inherent to the adult-centric nature of institutions and decision-making processes, and without necessary orientation and support young people can be left disempowered. The accessibility of opportunities across diverse groups of young people should be a key priority. Funding is another notable barrier to equitable youth participation. Planetary health organisations must, therefore, allocate funding for youth engagement, including adequately remunerating young people for the time and expertise they contribute." 915 1638 W2974448360.pdf 2 4 separator 0.97134256 ¶ 1638 1640 W2974448360.pdf 2 5 text 0.99940807 "Third, the planetary health sector must hold itself accountable for the adequacy and efficacy of its youth engagement and strive for consistent improvement. To this end, young people should be involved in the design and implementation of appropriate monitoring and evaluation frameworks. The sector would benefit from developing a common set of indicators of youth engagement. Monitoring and evaluation should occur systematically and consistently and provide a basis for young people to both provide and receive regular feedback on their participation in planetary health initiatives." 1640 2229 W2974448360.pdf 2 6 separator 0.97664464 ¶ 2229 2231 W2974448360.pdf 2 7 text 0.9994758 "Finally, the planetary health sector should work to enhance the evidence base supporting youth participation in public health programs, governance, and resource management. Doing so would help to provide a mandate for youth leadership in a variety of sectors and help counter misguided assumptions about the efficacy of youth input in shaping health priorities and action in local, national, and international arenas. Planetary health journals should seek out and publish evidence on the efficacy of youth-driven initiatives." 2231 2760 W2974448360.pdf 2 8 separator 0.9882794 ¶ 2760 2762 W2974448360.pdf 2 9 text 0.99899113 "Youth have spoken over recent years and their voices only grow louder. It is no longer enough to pursue sustainable development for them, it must be done with them. Their unique perspectives, attributes, and experiences must be sincerely valued. Planetary health has the opportunity to exemplify what it means to meaningfully engage youth. In this Comment, we detail principles essential for shifting from tokenistic to meaningful youth engagement. By focusing on broad consultation, facilitation, accountability, and building an evidence base, we can achieve this essential goal. We call on the planetary health community to reflect on its values and framework and realise that empowerment," 2762 3457 W2974448360.pdf 2 10 separator 0.995933 ¶ 3458 3460 W2974448360.pdf 2 11 title 0.9904076 Panel: Case studies of the practice points in action 3460 3513 W2974448360.pdf 2 12 separator 0.99343014 ¶ 3514 3516 W2974448360.pdf 2 13 title 0.9742032 Consultation 3516 3529 W2974448360.pdf 2 14 separator 0.891948 ¶ 3529 3531 W2974448360.pdf 2 15 text 0.99928653 "Canada’s Prime Minister’s Youth Council is an initiative that provides a platform for a diverse group of youth to offer advice, both in person and online, to the highest levels of government; issues advised on were not limited to those explicitly concerning youth, but included areas such as the economy and climate policy." 3531 3858 W2974448360.pdf 2 16 separator 0.9916179 ¶ 3858 3860 W2974448360.pdf 2 17 title 0.9746859 Facilitation 3860 3873 W2974448360.pdf 2 18 separator 0.9204057 ¶ 3873 3875 W2974448360.pdf 2 19 text 0.99943453 Women Deliver is a global program offering female youth advocates opportunities to develop advocacy skills through access to media experiences at institutions such as the BBC and Guardian, mentorship, and training; further personal development is achieved through provision of small grants or scholarships to attend the Women Deliver Global Conference and access to an alumni network. 3875 4260 W2974448360.pdf 2 20 separator 0.9952005 ¶ 4260 4262 W2974448360.pdf 2 21 title 0.9817146 Accountability 4262 4277 W2974448360.pdf 2 22 separator 0.9541982 ¶ 4277 4279 W2974448360.pdf 2 23 text 0.99917006 "In 2009, the UN Population Fund in Nepal did a youth audit to assess the degree of meaningful youth engagement within their organisation; the audit tool was developed and implemented with youth input at all stages." 4279 4497 W2974448360.pdf 2 24 separator 0.99567723 ¶ 4497 4499 W2974448360.pdf 2 25 title 0.98351514 Evidence 4499 4508 W2974448360.pdf 2 26 separator 0.98308575 ¶ 4508 4510 W2974448360.pdf 2 27 text 0.9744376 "Youth Lead the Change: Participatory Budgeting Boston was a project lead by the city of Boston, which allocated US$1 million to implement community initiatives proposed and voted for by youth; materials were translated, underserved areas were targeted, and text messaging was used to contact those unable to participate in person. Researchers created publicly available evidence about the program’s impact through attending meetings and conducting post–ante interviews.For more on Canada’s Prime Minister" 4510 5018 W2974448360.pdf 2 28 bibliography 0.45063052 ’ 5018 5019 W2974448360.pdf 2 29 text 0.6361855 s Youth Council 5019 5034 W2974448360.pdf 2 30 bibliography 0.44676366 see ¶ 5034 5041 W2974448360.pdf 2 31 text 0.76196086 https://www.canada.ca/en/ 5041 5067 W2974448360.pdf 2 32 bibliography 0.39404595 ¶ 5067 5069 W2974448360.pdf 2 33 text 0.53740823 campaign/prime-ministers- ¶ 5069 5097 W2974448360.pdf 2 34 bibliography 0.44776276 5097 5098 W2974448360.pdf 2 35 text 0.5444318 youth-council.html 5098 5116 W2974448360.pdf 2 36 separator 0.8989199 ¶ 5116 5118 W2974448360.pdf 2 37 bibliography 0.48233926 For more 5118 5127 W2974448360.pdf 2 38 text 0.49885312 on Women 5127 5136 W2974448360.pdf 2 39 bibliography 0.5149073 "Deliver see https://" 5136 5160 W2974448360.pdf 2 40 text 0.5077788 womendeliver.org 5160 5176 W2974448360.pdf 2 41 bibliography 0.5141497 / 5176 5177 W2974448360.pdf 2 42 separator 0.9595384 ¶ 5177 5179 W2974448360.pdf 2 43 bibliography 0.6135059 "From more on UN Population Fund in Nepal see https://www. unfpa.org/data/transparency- portal/unfpa-nepal" 5179 5292 W2974448360.pdf 2 44 separator 0.9718197 ¶ 5292 5294 W2974448360.pdf 2 45 text 0.5769049 "For more on Youth Lead the Change: Participatory Budgeting Boston see" 5294 5370 W2974448360.pdf 2 46 bibliography 0.41490495 ¶ 5371 5373 W2974448360.pdf 2 47 text 0.6411259 https://use.metropolis.org/ 5373 5401 W2974448360.pdf 2 48 bibliography 0.56073254 "case- studies/" 5401 5417 W2974448360.pdf 2 49 text 0.47044998 youth 5417 5422 W2974448360.pdf 2 50 bibliography 0.45919532 -lead 5422 5427 W2974448360.pdf 2 51 text 0.46835876 - 5427 5428 W2974448360.pdf 2 52 bibliography 0.5070645 "the-change- participa" 5428 5451 W2974448360.pdf 2 53 text 0.47704047 tory 5451 5455 W2974448360.pdf 2 54 bibliography 0.4619857 - 5455 5456 W2974448360.pdf 2 55 text 0.47684634 budgeting 5456 5465 W2974448360.pdf 2 56 bibliography 0.52935827 "- boston#casestudydetail" 5465 5491 W2974448360.pdf 2 0 paratext 0.98790306 Eur. Phys. J. C (2018) 78 :354 Page 3 of 4 354 0 46 W2800641949.pdf 2 1 separator 0.97514355 ¶ 46 48 W2800641949.pdf 2 2 table 0.9722164 "0 10000 20000 30000 40000 50000 60000 70000 80000 90000 0 2 4 6 8 10 12 14|Jy| (-h units) b (fm)" 49 158 W2800641949.pdf 2 3 separator 0.98610556 ¶ 158 160 W2800641949.pdf 2 4 caption 0.9905157 "Fig. 10 Estimated angular momentum (in ̄hunits) of the overlap region of the two colliding nuclei (solid line) and total angular momentum ofthe plasma according to the parametrization of the initial conditions(dashed line), as a function of the impact parameter" 160 424 W2800641949.pdf 2 5 separator 0.690139 ¶ 424 426 W2800641949.pdf 2 6 table 0.7723959 "0 0.05 0.1 0.15 0.2 0.25 0 0.04 0.08 0.12 0.16 η/sτx τy τη xy yη ηx" 427 514 W2800641949.pdf 2 7 separator 0.9459832 ¶ 514 516 W2800641949.pdf 2 8 caption 0.9616484 "Fig. 11 Mean of the absolute value of thermal vorticity covariant components at the freeze-out as a function of η/s. Note that the" 516 649 W2800641949.pdf 2 9 text 0.6307411 ¶ /pi1xη,/pi1 yη,/pi1τηhave been multiplied by 1 649 698 W2800641949.pdf 2 10 math 0.3960181 / 698 700 W2800641949.pdf 2 11 text 0.3739623 τ 700 701 W2800641949.pdf 2 12 math 0.5897895 "-0.008-0.007-0.006-0.005-0.004-0.003-0.002-0.001 0 0.001 0 " 701 764 W2800641949.pdf 2 13 table 0.46685737 0.04 764 768 W2800641949.pdf 2 14 math 0.48298422 769 770 W2800641949.pdf 2 15 table 0.47487694 0.08 770 774 W2800641949.pdf 2 16 math 0.5114207 775 776 W2800641949.pdf 2 17 table 0.46417332 0.12 776 780 W2800641949.pdf 2 18 math 0.53826284 "0.16 η/sτx τy τη xy yη ¶" 781 816 W2800641949.pdf 2 19 table 0.48598728 ηx 816 819 W2800641949.pdf 2 20 separator 0.94542736 ¶ 819 821 W2800641949.pdf 2 21 caption 0.90976995 "Fig. 12 Mean values of thermal vorticity components at the freeze-out as a function of η/s. Note that" 821 925 W2800641949.pdf 2 22 text 0.68797404 the /pi1xη,/pi1 yη,/pi1τηhave been 925 960 W2800641949.pdf 2 23 caption 0.44104454 multipli 960 969 W2800641949.pdf 2 24 text 0.4927832 ed 969 971 W2800641949.pdf 2 25 separator 0.52610284 ¶ 971 973 W2800641949.pdf 2 26 caption 0.3603456 by 1 973 978 W2800641949.pdf 2 27 math 0.29372004 / 978 979 W2800641949.pdf 2 28 text 0.2847542 τ 979 980 W2800641949.pdf 2 29 separator 0.535522 ¶ 980 982 W2800641949.pdf 2 30 math 0.64315933 "-4-2 0 2 4 -4 -2 0 2 4x (fm) η-0.05-" 982 1026 W2800641949.pdf 2 31 table 0.44811222 0.04 1026 1030 W2800641949.pdf 2 32 math 0.51201797 - 1030 1031 W2800641949.pdf 2 33 table 0.4498272 0.03 1031 1035 W2800641949.pdf 2 34 math 0.4852604 -0.02- 1035 1041 W2800641949.pdf 2 35 table 0.51008993 0.01 0 0.01 0.02 0.03 1041 1062 W2800641949.pdf 2 36 separator 0.9634552 ¶ 1062 1064 W2800641949.pdf 2 37 caption 0.94559836 "Fig. 13 Contour plot of 1 /τ-scaled ηxcovariant component of the thermal vorticity, /pi1ηx/τover the freeze-out hypersurface for y=0, η/s=0.1,ηm=2.0" 1064 1217 W2800641949.pdf 2 38 separator 0.99025786 ¶ 1217 1219 W2800641949.pdf 2 39 paratext 0.9507873 123 1219 1223 W2800641949.pdf 2 0 title 0.98099977 Materials and Methods 0 21 W2094665636.pdf 1 1 separator 0.99455416 ¶ 21 23 W2094665636.pdf 1 2 title 0.9685597 Animals 23 31 W2094665636.pdf 1 3 separator 0.9899308 ¶ 31 33 W2094665636.pdf 1 4 text 0.99933404 "Female 8-weeks-old Sprague-Dawley rats (CLEA Japan, Japan) were used in this study. All animals were quarantined and acclimatized for 1 week prior to the experiments under the following general conditions: room temperature of 23 62uC, relative humidity of 60 610%, alternating 12-hour light-dark cycle (8 AM to 8 PM), and water and food ad libitum . All animals were used according to the Association of Research and Vision in Ophthalmology (ARVO) statement for the Use of Animals in Ophthalmic and Vision Research. The protocol for this study was approved by the Ethics Committee on Animal Research of the Keio University School of Medicine (Approval No. 11008-2)." 33 719 W2094665636.pdf 1 5 separator 0.9961978 ¶ 719 721 W2094665636.pdf 1 6 title 0.99031746 Honey bee products 721 740 W2094665636.pdf 1 7 separator 0.99426734 ¶ 740 742 W2094665636.pdf 1 8 text 0.99950427 "Raw honey, an ethanolic extract of propolis, the lyophilized powder of RJ, pollen granules, and the lyophilized powder of larva were used. The detailed information of each honey bee products used in this study is described in Table S1. All honey bee products were supplied by Yamada Bee Company, Inc. (Okayama, Japan)." 742 1069 W2094665636.pdf 1 9 separator 0.99693954 ¶ 1069 1071 W2094665636.pdf 1 10 title 0.99063456 Protein secretion from isolated LGs 1071 1107 W2094665636.pdf 1 11 separator 0.9923551 ¶ 1107 1109 W2094665636.pdf 1 12 text 0.99959296 "Rats were euthanized by excess pentobarbital administration and their LG were rapidly dissected. LG digested by collagenase type 3 (Worthington, USA) was incubated in saline solution (140 mM NaCl, 5 mM KCl, 2 mM CaCl 2, 1 mM MgCl 2,1 0m M HEPES, 10 mM dextrose [pH 7.4]) with each honey bee product." 1109 1417 W2094665636.pdf 1 13 separator 0.84128225 ¶ 1417 1419 W2094665636.pdf 1 14 text 0.99963135 "Carbachol (CCH), a cholinergic stimulus, was used as a positive control. The protein concentration in the medium was measured using the Bradford reagent (Sigma-Aldrich, USA) with bovine serum albumin (BSA) as the standard. The protein secretion rate was calculated as a percentage of that the before stimulation. 5 rats were used in each group." 1419 1774 W2094665636.pdf 1 15 separator 0.9966302 ¶ 1774 1776 W2094665636.pdf 1 16 title 0.9926431 Rat blink-suppressed dry eye model 1776 1811 W2094665636.pdf 1 17 separator 0.99276483 ¶ 1811 1813 W2094665636.pdf 1 18 text 0.999668 "The model and methodology used to simulate VDT has been described previously [7,20,21]. In brief, a series of treatments were performed under dry conditions, with a room temperature of 2362uC, relative humidity of 25 65%, and constant air flow at 2 to 4 m/s produced by an electric fan. Each rat was placed on a swing for 7.5 hours per day between 9 AM and 5 PM. Aphotograph of the rat blink-suppressed model was shown in figure S1. This series of treatment, procedure to simulate VDT in rat, was repeated for 5 days for screening of honey bee products and 10days for the RJ evaluation. Each honey bee product was dissolved in distilled water at 240 mg/ml (honey), 40 mg/ml (pollen, larva, and propolis), and 60 mg/ml (RJ) and was repeatedly administered orally each 1 ml to rats once a day." 1813 2627 W2094665636.pdf 1 19 separator 0.90765226 ¶ 2627 2629 W2094665636.pdf 1 20 text 0.99965155 "Distilled water was used as vehicle control. To screen honey bee products at the effective dose for health benefits, the dosage of each honey bee product was chosen by reference to previous reports [14,22,23]. Lacrimal function was evaluated on day 11." 2629 2888 W2094665636.pdf 1 21 separator 0.7839192 ¶ 2888 2890 W2094665636.pdf 1 22 text 0.9993651 "For each experiment using rat blink-suppressed dry eye model, 6 to 18 rats were used in each group." 2890 2992 W2094665636.pdf 1 23 separator 0.9638965 ¶ 2992 2994 W2094665636.pdf 1 24 text 0.9995768 "Tear secretion. We used a modified Schirmer test on rat eyes to measurement tear fluid secretion under topical anesthesia by 0.4% oxybuprocaine hydrochloride solution (Santen Pharma- ceutical, Japan) [24]. A phenol red thread (Zone-Quick; Showa Yakuhin kako, Japan) was placed on the temporal side of the upper eyelid margin for 1 minute. The length of the moistened area from the edge was measured within 1 mm." 2994 3418 W2094665636.pdf 1 25 separator 0.9575547 ¶ 3418 3420 W2094665636.pdf 1 26 text 0.9992155 "Corneal fluorescein staining. Changes in the corneal surface were determined by the application of a fluoresceinsolution under a blue-free barrier filter [25], and corneal staining of the area was graded according to previously described criteria [20]." 3420 3679 W2094665636.pdf 1 27 separator 0.96208113 ¶ 3679 3681 W2094665636.pdf 1 28 text 0.9995427 "Histopathological examination. The fixed LG in 10% formalin was embedded in paraffin and sectioned. Sections were subjected to HE staining or immunostaining. The acinar cell density of each section was determined by quantifying the nuclear number in three randomly selected areas (2500 mm2)." 3681 3981 W2094665636.pdf 1 29 separator 0.9533267 ¶ 3981 3983 W2094665636.pdf 1 30 text 0.99956757 "Vesicle-associated membrane protein 8 (VAMP8) was immnos- tained to evaluate the occupied pattern of secretory vesicles (SVs) in the acinar cells of specimens. VAMP8 was previously shown to be enriched on the membranes of zymogen granules [26]. The primary antibody used for immunostaining was a rabbit mono- clonal antibody against VAMP8 (Abcam, UK). Nuclear staining was performed by treating specimens with hematoxylin." 3983 4418 W2094665636.pdf 1 31 separator 0.9761926 ¶ 4418 4420 W2094665636.pdf 1 32 text 0.9996094 "Mitochondrial function. The homogenized LG was exam- ined to measure ATP levels and mitochondrial content. ATP levels were determined according to the instructions for the ATP Bioluminescence Assay Kit CLS 2 (Roche Molecular Biochemi- cals, Germany). Mitochondrial content was measured by using the fluorescence dye, Mitotracker green FM (Molecular Probes, USA) and Hoechst 33342 (Dojin Chemical, Japan). These measurements were performed on a Synergy 4 plate reader (Biotek Company, USA). The mitochondrial membrane potential of the LG was visualized by staining with Mitotracker red (Invitrogen), a membrane potential-dependent fluorescence dye." 4420 5088 W2094665636.pdf 1 33 separator 0.9673188 ¶ 5088 5090 W2094665636.pdf 1 34 text 0.9996463 "Western blot. Total protein extracts from the LG were separated by polyacrylamide gel electrophoresis, transferred to PVDF membranes using a dry blotting system (V20-SDB, SCIE- PLAS, UK), and incubated with antibodies. Immunolabeled proteins were detected using Pierce Western blotting Substrate Plus (Thermo SCIENTIFIC, Germany) and a Lumino-image analyzer (LAS-4000, FujiFilm, Japan). All bands were normalized tob-actin. The primary antibodies used for Western blotting were as follows; AMP-activated protein kinase [AMPK (Cell Signaling, Japan), Phospho-AMPK (Cell Signaling)], and b-actin (Sigma Aldrich). 6rats were used in each group." 5090 5752 W2094665636.pdf 1 35 separator 0.99689776 ¶ 5752 5754 W2094665636.pdf 1 36 title 0.9538939 "Intracellular calcium ion concentration ([Ca2+]i ) measurements" 5754 5820 W2094665636.pdf 1 37 separator 0.9909709 ¶ 5820 5822 W2094665636.pdf 1 38 text 0.9995762 "The LG digested by collagenase type 3 was filtered through a 100mm nylon mesh (Cell Strainer, BD Biosciences, Japan) to isolate LG acinar cells. Acinar cells were loaded with fura-2/AM (Invitrogen, USA), the fluorescent Ca2+indicator, and transferred to round coverslips. Coverslips were then mounted on a chamber fixed on the stage of an inverted fluorescence microscope (IX71, Olympus, Japan). Acinar cells were continuously perfused with diverse experimental solutions through polyethylene tubes con- nected to a peristaltic pump (Minipulse 3, Gilson, USA) at flowrate of 0.8 ml per minutes." 5822 6433 W2094665636.pdf 1 39 separator 0.9637029 ¶ 6433 6435 W2094665636.pdf 1 40 text 0.99855673 "Royal jelly (100, 300, and 500 mg/ml), CCH (10 mM; Tokyo Kasei Kougyo, Japan), and 10-hydroxy-2-decenoic acid (500 mg/ ml; 10-HDE, Cayman, USA) were diluted to the desired concentrations with saline solution and used as stimulants." 6435 6675 W2094665636.pdf 1 41 separator 0.92172754 ¶ 6675 6677 W2094665636.pdf 1 42 text 0.99927855 "AG1478 (10 mM; Wako, Japan), Atropine sulfate (1 mM; Nacalai, Japan), U73122 (1 mM; Sigma, Japan), and cyclopiazonic acid (10mM; CPA, Sigma, Japan) were appropriately prepared in saline solution before use. Changes in [Ca2+]i were measured by dual excitation microfluorometry using a digital image analyzer (Aqua Cosmos/Ratio, Hamamatsu Photonics, Japan). The fluo- rescence signal was detected using UV objective lens (UApo2063/340, Olympus), and the emission passing through a band pass filter (500 610 nm) was detected by a cooled CCD camera (ORCAER, Hamamatsu Photonics, Japan). Data acquisition wasRoyal Jelly as Prevention Intervention for Dry Eye" 6677 7347 W2094665636.pdf 1 43 separator 0.8756902 ¶ 7347 7349 W2094665636.pdf 1 44 paratext 0.9855275 PLOS ONE | www.plosone.org 2 September 2014 | Volume 9 | Issue 9 | e106338 7349 7424 W2094665636.pdf 1 0 text 0.99559945 "GSA 2019 Annual Scientific Meetingthe care recipient (2%) were enunciated as areas requiring training. Many of the training needs should be addressed by healthcare professionals in their interactions with caregivers and care recipients. Programs are available online, but care - givers are not accessing this training. To improve outcomes for both caregivers and care recipients targeted training for caregivers is needed." 0 439 W2988610680.pdf 0 1 separator 0.9949254 ¶ 439 441 W2988610680.pdf 0 2 title 0.9867575 "PUBLIC HEALTH AND SOCIAL SERVICES SYSTEM: THE DISENCHANTMENT OF ISOLATED SENIOR CAREGIVERS" 441 538 W2988610680.pdf 0 3 separator 0.9903225 ¶ 538 540 W2988610680.pdf 0 4 contact 0.9925266 "Melanie Couture ,1 Pam Orzeck ,2 and Apostolia Petropoulos3, 1. Centre for research and expertise in social gerontology, CIUSSS West-Central Montreal, Montreal, Quebec, Canada, 2. McGill University, Montreal, Quebec, Canada, 3. Jewish Eldercare Centre, Montreal, Quebec, Canada" 540 836 W2988610680.pdf 0 5 separator 0.9930762 ¶ 836 838 W2988610680.pdf 0 6 text 0.9994806 "Social isolation is one of the negative consequences asso - ciated with caregiving and is experienced by approximately 20% of Canadian family caregivers. Being in a public health and social services system, Canadian caregivers should nor - mally turn to their local community service centres (CLSC) to access formal services and feel less isolated. However, studies have shown that satisfaction is low regarding acces - sibility and continuity of formal support services. In an effort to develop interventions that meet the needs of isolated senior caregivers, the purpose of this exploratory descriptive qualita - tive study was to identify challenges encountered in accessing and utilizing formal supports within the public health and so - cial services system in Canada. Nineteen isolated senior care - givers participated in seven focus groups. Data analysis was performed using the Miles, Huberman, and Saldana (2014) approach. Results showed that isolated caregivers do not know where to get information about existing services within the formal system. Once services are found, waiting lists are linked to unbearable delays. Some caregivers are actually re - directed to private services, if they can afford it. Isolated care - givers also criticize the unpredictability of the system as they face relentless changes of care providers, inadequate services and sometimes unwarranted cancellations or terminations. In addition, they find formal services lacking human sensitivity." 838 2385 W2988610680.pdf 0 7 separator 0.6979936 ¶ 2386 2388 W2988610680.pdf 0 8 text 0.9990668 "Many of them come to the conclusion that formal services are not worthwhile and exclude themselves from the formal system. This research demonstrated that the health and social services system can actually contribute to the social isolation of senior caregivers longing for support." 2388 2683 W2988610680.pdf 0 9 separator 0.9952693 ¶ 2683 2685 W2988610680.pdf 0 10 title 0.98583525 SESSION 2050 (SYMPOSIUM) 2685 2710 W2988610680.pdf 0 11 separator 0.89591527 ¶ 2710 2712 W2988610680.pdf 0 12 title 0.98213816 "FROM BIG DATA TO COMMUNITY SETTINGS: HOW CAN EXERCISE IMPROVE HEALTH OUTCOMES IN OLDER CANCER SURVIVORS?" 2712 2823 W2988610680.pdf 0 13 separator 0.98541236 ¶ 2823 2825 W2988610680.pdf 0 14 contact 0.98573464 "Chair: Shirley M. Bluethmann , The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States Discussant: Corinne Leach , American Cancer Society, Atlanta, Georgia, United States" 2825 3045 W2988610680.pdf 0 15 separator 0.9941502 ¶ 3045 3047 W2988610680.pdf 0 16 text 0.99934 "Current guidelines recommend that survivors achieve regular physical activity and reduced inactivity to attenuate cancer and mortality risk and to promote quality of life. Optimal ways of obtaining physical activity or measuring how much exercise has been achieved continues to be a challenge, especially among older adults and cancer sur - vivors. Our symposium will provide insights using big data to understand population level patterns of activity and po - tential benefits for survivors, examining implications for survival and key health outcomes, including multimorbidity and functional limitations. We will also discuss social and environmental determinants that may be important for older survivors in designing community interventions, especially in rural communities. These include considerations related to the built environment and social support to promote leisure- time physical activity in older survivors." 3047 4009 W2988610680.pdf 0 17 separator 0.9969495 ¶ 4009 4011 W2988610680.pdf 0 18 title 0.98952633 "PHYSICAL ACTIVITY AND SEDENTARY BEHAVIORS: IMPACT ON SELF-RATED HEALTH AND PHYSICAL OUTCOMES IN CANCER SURVIVORS" 4011 4130 W2988610680.pdf 0 19 separator 0.99440134 ¶ 4130 4132 W2988610680.pdf 0 20 contact 0.9497896 "Shirley M. Bluethmann ,1 Eileen Flores ,2 Charles Matthews ,3 and Frank Perna3, 1. The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States, 2. Penn State College of Medicine, Hershey, Pennsylvania, United States, 3. National Cancer Institute, Rockville, Maryland, United States" 4132 4464 W2988610680.pdf 0 21 separator 0.9942518 ¶ 4464 4466 W2988610680.pdf 0 22 text 0.99946535 "Physical activity (PA) and avoidance of inactivity are re - commended in cancer survivorship. But survivors are not meeting these recommendations. We used national data (NHANES) collected 2011-2014 (n=9620) to estimate asso - ciations of PA and TV viewing with 3 health outcomes: self- rated health, functional limitations and multimorbidity in older cancer survivors and adults without cancer. Greater PA was associated with reporting excellent health in survivors." 4466 4951 W2988610680.pdf 0 23 separator 0.9414478 ¶ 4952 4954 W2988610680.pdf 0 24 text 0.999491 "Survivors that obtained 22.5+ MET-hours/week were 5.5 times more likely to report excellent health than those that did no exercise (OR=5.5, p<.001). We observed a decrease in likelihood of multimorbidity and functional limitations with increasing PA (both significant at p<.001). We noted survivors that abstained from watching TV were 3x more likely to report excellent health and between 60-80% less likely to report functional limitations and multimorbidity than TV watchers (p<001). Findings with non-cancer adults were similar. Survivors need PA and reduced TV to maximize health outcomes." 4954 5579 W2988610680.pdf 0 25 separator 0.9963962 ¶ 5579 5581 W2988610680.pdf 0 26 title 0.99096096 "SELF-REPORTED WALKING PACE AND ALL-CAUSE MORTALITY AMONG CANCER SURVIVORS IN THE NIH-AARP DIET AND HEALTH STUDY" 5581 5699 W2988610680.pdf 0 27 separator 0.99075234 ¶ 5699 5701 W2988610680.pdf 0 28 bibliography 0.5201759 "Elizabeth Salerno ,1 Pedro Saint Maurice ,1 Erik Willis ,1 Loretta" 5701 5771 W2988610680.pdf 0 29 contact 0.48399487 Di 5771 5774 W2988610680.pdf 0 30 bibliography 0.5115469 Pietro ,2 and Charles Matthew 5774 5803 W2988610680.pdf 0 31 contact 0.51062375 s 5803 5804 W2988610680.pdf 0 32 bibliography 0.4971331 1 5804 5805 W2988610680.pdf 0 33 contact 0.79482263 ", 1. National Cancer Institute, Rockville, Maryland, United States, 2. George Washington University, Washington, District of Columbia, United States" 5805 5963 W2988610680.pdf 0 34 separator 0.9935963 ¶ 5963 5965 W2988610680.pdf 0 35 text 0.99767023 "We examined the association between self-reported walking pace and all-cause mortality among cancer survivors in the NIH-AARP Diet and Health Study. Participants in - cluded 30,110 adults (Mage=62.4+/-5.14 years) diagnosed with cancer between study enrollment and follow-up, when they self-reported walking pace. Individuals were followed until death or administrative censoring in 2011. We esti - mated the hazards ratios (HR) and 95% confidence inter - vals (CI) for walking pace and all-cause mortality adjusting for age, sex, race, BMI, health status," 5965 6546 W2988610680.pdf 0 36 paratext 0.93499833 6546 6547 W2988610680.pdf 0 37 text 0.8395548 physical activity and 6547 6568 W2988610680.pdf 0 38 paratext 0.98069245 Innovation in Aging , 2019, Vol. 3, No. S1 387Downloaded from https://academic.oup.com/innovateage/article/3/Supplement_1/S387/5616132 by guest on 18 May 2024 6568 6728 W2988610680.pdf 0 39 separator 0.9953779 ¶ 6728 6730 W2988610680.pdf 0 0 paratext 0.9762774 213 0 3 W4378883284.pdf 4 1 separator 0.9847099 ¶ 3 5 W4378883284.pdf 4 2 title 0.9662123 From proper names to common nouns 6 40 W4378883284.pdf 4 3 separator 0.9814879 ¶ 40 42 W4378883284.pdf 4 4 text 0.9962283 "of German, where there are the -i smus formations, but the verbs which are formed from proper names and are comparable to the It. -e ggiare verbs are normally created by conversion (cf. Donalies 2000): e.g. thomasmannen , hei- deggern , poppern , barzeln , brahmsen , möllemannen , wagnern , fringsen , morsen , röntgen , haidern , goethen , kulicken , töpfern , schwätzern .4" 42 437 W4378883284.pdf 4 5 separator 0.9967663 ¶ 437 439 W4378883284.pdf 4 6 title 0.99120945 2. The crucial problem with proper names: the lexical meaning 439 501 W4378883284.pdf 4 7 separator 0.99184704 ¶ 501 503 W4378883284.pdf 4 8 text 0.98936045 "The first problem we are faced with concerns the meaning of the derived nouns in It. -i smo/ -i sta and AG -i smós / -i stḗs which have a proper name as lexical base. According to Bergien (2011, 2013), we assume that proper names have a connotative value, and that the meaning of the proper names is built “online” and depends on the cultural meaning and the shared knowledge of the participants to the communication." 503 946 W4378883284.pdf 4 9 separator 0.6709198 ¶ 946 948 W4378883284.pdf 4 10 text 0.9936855 "5 The cultural specificity of proper names is also underlined by Thurmair (2002a) who argues that every culture has a specific thesaurus of proper names, i.e. persons, institutions, places, brand names, etc. the knowledge of which is necessary to participate in public relevant discourse. Obviously that knowledge varies from culture to culture and requires an extensive linguistic competence of the connotations related with specific proper names. We can distinguish proper names of universal, occidental, European, or language specific, e.g. Italian or German, relevance. Especially in journalistic texts there is a continuously varying inventory of" 948 1603 W4378883284.pdf 4 11 separator 0.9568665 ¶ 1604 1606 W4378883284.pdf 4 12 text 0.9963649 "4 T he lexical bases are respectively: Thomas Mann, Martin Heidegger, Karl Popper, Rainer Barzel, Johannes Brahms, Jürgen Möllemann, Richard Wagner, Kardinal Joseph Frings, Samuel F.B. Morse, Wilhelm Conrad Röntgen, Jörg Haider, Johann Wolfgang von Goethe, Atze Kulicke, Klaus Töpfer, Irmgard Schwaetzer. However, even a German native speaker, in order to understand the formations, needs a comprehensive, specific knowledge of the person and the characteristics, behaviour etc. for whom he/she is famous for, denoted in the morphological base. Only in that way it is possible to decide if the verb belongs to class (a) ‘to behave, look like, talk, write or think like X’ as in the case of thomasmannen or to class (b) ‘to conduct or act following the methods or ideas of X’ as in the case of fringsen ‘to steal food and fuel in a justified manner’; for the classes cf. Donalies (2000) and Section 2 below." 1606 2527 W4378883284.pdf 4 13 separator 0.8995967 ¶ 5 ¶ 2527 2533 W4378883284.pdf 4 14 text 0.9991476 "I t is well known that the topic of the meaning of proper names has been a longstanding problem for both logicians and linguists. Among the philosophers and logicians, Mill (1843), Russell (1940), Gardiner (1954) and Kripke (1980) must be mentioned at least; among the linguists, interesting reflections on the subject have been proposed by Jes - persen (1924), Pulgram (1954), Jakobson (1957), Kuryłowicz (1966), Kleiber (1981); for an overview of the different topics concerning the proper names cf. Gary-Prieur (1994), Vaxelaire (2005) and Anderson (2007)." 2534 3101 W4378883284.pdf 4 15 separator 0.9249649 ¶ ¶ 3101 3107 W4378883284.pdf 4 16 paratext 0.9784596 Dieses Werk ist lizenziert unter einer Creative Commons -BY 3.0 Deutschland Lizenz . http://creativecommons.org/licenses/by/3.0/de/ 3107 3240 W4378883284.pdf 4 17 separator 0.99498093 ¶ 3242 3244 W4378883284.pdf 4 0 paratext 0.97907233 869 Kyathanahally SP, et al. J Neurol Neurosurg Psychiatry 2021;92:863–871. doi:10.1136/jnnp-2020-325580Spinal cord injury 0 122 W3164013352.pdf 6 1 separator 0.9861357 ¶ 122 124 W3164013352.pdf 6 2 text 0.85143834 "Communication between the prefrontal cortical areas and the PAG has been recently shown in functional MRI studies.34" 124 244 W3164013352.pdf 6 3 separator 0.938866 ¶ 245 247 W3164013352.pdf 6 4 text 0.8450696 Here, we provide evidence for further downstream effects. 247 305 W3164013352.pdf 6 5 separator 0.7680718 ¶ 306 308 W3164013352.pdf 6 6 text 0.99962044 Notably, microstructural alterations were detected within the spinal cord and also the PAG. These effects were related to pain intensity; furnishing an important predictive validity to this imaging phenotype. The PAG is known to serve as a link between the forebrain and the lower brainstem and is pivotal for the descending modulation of pain. It receives input from the frontal lobe, amygdala, hypothalamus and ACC and engages the rostral ventral medulla which in turn controls nociceptive processing in the spinal dorsal horn. 308 838 W3164013352.pdf 6 7 separator 0.95143867 ¶ 838 840 W3164013352.pdf 6 8 text 0.9728214 "35 Direct stimulation of the PAG has successfully been trialled as a treatment option for NP including pain following SCI." 840 966 W3164013352.pdf 6 9 separator 0.844067 ¶ 966 968 W3164013352.pdf 6 10 text 0.9976083 "36 Thus, it is anticipated that molecular changes in the PAG could compromise descending inhibition of nociceptive processing and subsequently increase the spinal gain of incoming information. Our study is the first to provide evidence for NP- related changes in P AG microstructure in humans, underscoring the clinical relevance of these changes for NP following SCI. In conjunction with microstructural alter - ation in the injured spinal cord, these findings are compatible with the notion of a dysfunctional spinal–bulbo–spinal loop, a key circuit of the descending pain modulatory system." 968 1575 W3164013352.pdf 6 11 separator 0.9036125 ¶ 1575 1577 W3164013352.pdf 6 12 text 0.612116 3 1577 1579 W3164013352.pdf 6 13 separator 0.9597236 ¶ 1579 1581 W3164013352.pdf 6 14 text 0.9984406 "Additional evidence for an impaired descending pain modu- latory system can be inferred from microstructural changes in other key constituents of this network, namely the ACC (ie, increased iron accumulation) and DLPFC circuitry 4 (ie, reduced myelin content). Previous studies had found structural and func-tional NP associations in the DLPFC 37 in those with NP . For example, reduced GM volume and hypometabolisms in the left DLPFC were observed in SCI patients suffering from NP when compared with healthy controls." 1581 2113 W3164013352.pdf 6 15 separator 0.8399662 ¶ 2113 2115 W3164013352.pdf 6 16 text 0.9989303 "38 Here, we not only show that this reduction in volume is linked to a decrease in myelin- sensitive R1, but also that it is pain specific—as this reduction was not observed in pain- free patients. As the DLPFC is both involved in top- down inhibition and facilit ation of pain, the decreases in myelin content reported herein align well with the concept of pathological nociceptive gain control in NP after SCI." 2115 2551 W3164013352.pdf 6 17 separator 0.96491426 ¶ 2551 2553 W3164013352.pdf 6 18 paratext 0.3749412 2 2553 2555 W3164013352.pdf 6 19 separator 0.9864227 ¶ 2555 2557 W3164013352.pdf 6 20 text 0.98321694 "The thalamus is considered to play an important role in the pathophysiology of central NP after SCI.32 After a spinal lesion ascending somatosensory pathways are damaged, which may result in deafferentation of rostral relay structures such as the thalamus. Intriguingly, our finding of R2* signal changes which may reflect iron accumulation in the thalamus in SCI patients with NP was confined to lateral thalamic nuclei, while volumetric changes in the medial thalamus were trauma- related (ie, found in SCI with and without NP). These findings offer an essential line of evidence that structural plasticity within the thalamus is specifically linked to the pathophysiology of NP after SCI." 2557 3267 W3164013352.pdf 6 21 separator 0.9712162 ¶ 3267 3269 W3164013352.pdf 6 22 text 0.9992515 "Finally, we observed an unexpected decrease of iron- sensitive R2* in the basal ganglia. The role of the basal ganglia in chronic pain conditions is still poorly understood, but its vast anatomical connections to a multitude of brain areas (including the thal-amus) and cervical cord make it plausible that the basal ganglia could play an important role in aberrant nociceptive bottom- up and top- down signalling (for review , see Borsook et al39). Our findings warrant further studies into the role of basal ganglia pathways in central NP . At present, the implications of these findings remain highly speculative." 3269 3912 W3164013352.pdf 6 23 separator 0.9844551 ¶ 3912 3914 W3164013352.pdf 6 24 text 0.99940115 "From a technical perspective, the multivariate (SBM) tests for group effects described above are, in principle, much more sensi-tive than the equivalent mass univariate (VBM) tests one would obtain from analysing the volumetric and microstructural images directly. This is because multivariate analyses do not try to assign a significance to each voxel or region—they test for distributed effects that covary among individuals." 3914 4345 W3164013352.pdf 6 25 separator 0.84987926 ¶ 4345 4347 W3164013352.pdf 6 26 text 0.8557454 "16 Crucially, this multivar - iate analysis would not have been possible without combining the brain and spinal cord within the same analysis. This speaks to the potential importance of the combined brain and spine template used to spatially normalise our data. This template is available through open access (http://www. ¶ fil. ion. ¶ ucl. ac. uk/ " 4347 4716 W3164013352.pdf 6 27 paratext 0.32265252 ¶ 4716 4717 W3164013352.pdf 6 28 text 0.44637656 "spm/ " 4718 4728 W3164013352.pdf 6 29 paratext 0.351409 ¶ 4728 4729 W3164013352.pdf 6 30 text 0.6569958 "toolbo x/ TPM/) for related studies that test for distributed effects throughout the neural axis." 4729 4835 W3164013352.pdf 6 31 separator 0.9899448 ¶ 4835 4837 W3164013352.pdf 6 32 title 0.9878086 LIMITATIONS 4837 4849 W3164013352.pdf 6 33 separator 0.99557173 ¶ 4849 4851 W3164013352.pdf 6 34 text 0.99336714 "Our study had some limitations. The cross- sectional nature of the study restricts conclusions to a single time point and thus the temporal evolution of the above- described microstructural changes remains uncertain. Despite the histological evidence that MT, R1 and R2* markers correspond to their biochemical coun-terparts 13, they are indirect contrasts of myelin and iron content and any interpretation should take this into consideration." 4851 5316 W3164013352.pdf 6 35 separator 0.85238624 ¶ 5316 5318 W3164013352.pdf 6 36 text 0.9989182 "It should be noted that concurrently observed changes in R2*, R1 and MT may not be apparent in all microstructural changes. First, the sensitivity or signal- to- noise ratio in these different quantitative ¶ measures varies significantly.40 Thus, differences in sensitivity may render these measures complementary, that is, certain changes may only be visible in one of the metrics. Second, the different metrics have a distinct specificity and sensitivity to underlying microstruc-tural changes." 5318 5831 W3164013352.pdf 6 37 separator 0.9548408 ¶ 5831 5833 W3164013352.pdf 6 38 text 0.63424903 "22 For example, R2* is exquisitely sensitive to changes in local susceptibility and concentration of paramagnetic compounds such as iron." 5833 5974 W3164013352.pdf 6 39 bibliography 0.5815474 Callaghan and colle 5974 5994 W3164013352.pdf 6 40 text 0.99673444 "agues 41 have demonstrated that R1 can be estimated from R2* and MT measurements by a general linear relaxometry model, which demonstrates that R2* and MT changes may even cancel each other and result in zero change in R1. Thus, partial contributions of unexplored physiological/cellular processes occurring after SCI cannot be excluded. Moreover, current standardised neurological tests cannot account for unobserved latent lifestyle or genetic factors which might be different between SCI patients and controls, a- priori. T o mitigate any potential effect of the scanner upgrade on our results, we ensured that the same number of patients and controls were measured before and after upgrade, allowing us to account for the upgrade effect (common to both cohorts) and modelled out any linear effect of these covariates of interest. Moreover, Leutritz et al 40 demonstrated that the system- atic bias in R1, MT and R2* measurements between a Skyra and Verio Siemens scanner setup is <4%. Thus, we are confident that the effects seen in this study are related to pathophysiological changes rather than technical sources. Finally, sex was not balanced across groups, with most of the participants being men. However, this is representative of the general population of SCI patients, in which the male to female patients’ ratio is roughly 4:1 and we also adjusted our models for this covariate of no interest." 5994 7418 W3164013352.pdf 6 41 separator 0.9943969 ¶ 7418 7420 W3164013352.pdf 6 42 title 0.99204034 CONCLUSION 7420 7431 W3164013352.pdf 6 43 separator 0.99658614 ¶ 7431 7433 W3164013352.pdf 6 44 text 0.9996246 This study evinces the microstructural signature of NP , affecting key constituents of the ascending and descending nociceptive pathways—its magnitude being directly linked to NP inten-sity. The complex interplay between myelin and iron changes in areas related to sensory and affective processing highlights maladaptive plastic processes likely involved in the maintenance of NP . Beyond unravelling the intimate pathophysiology of NP , tracking microstructural plasticity may facilitate patient moni-toring during clinical trials for NP . 7433 7974 W3164013352.pdf 6 45 separator 0.9961935 ¶ 7974 7976 W3164013352.pdf 6 46 paratext 0.5976291 Author affiliations 7976 7996 W3164013352.pdf 6 47 separator 0.6115092 ¶ 7996 7998 W3164013352.pdf 6 48 contact 0.937295 1Spinal Cord Injury Center, University Hospital Balgrist, University of Zurich, Zurich, 7998 8086 W3164013352.pdf 6 49 paratext 0.97527736 ¶ Switzerland on May 17, 2024 by guest. Protected by copyright. http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp-2020-325580 on 26 May 2021. Downloaded from 8087 8279 W3164013352.pdf 6 0 paratext 0.98801917 Photonics 2023 ,10, 1347 14 of 15 0 33 W4389385883.pdf 13 1 separator 0.9938734 ¶ 33 35 W4389385883.pdf 13 2 text 0.9985599 "measurements and estimations. We conducted a theoretical derivation to validate the effectiveness of this method. Then, we carried out simulations and experiments to conduct comparative frequency measurements and ranging trials. The findings reveal that our method can enhance the precision of both frequency and distance measurements by a factor of ten when contrasted with conventional techniques, and improved ranging outcomes are achievable even with large sweep increments." 35 523 W4389385883.pdf 13 3 separator 0.9956583 ¶ 523 525 W4389385883.pdf 13 4 bibliography 0.9737561 "Author Contributions: Conceptualization, S.G. and C.G.; methodology, S.G.; validation, S.G., Y.W., Y.M. and S.C.; writing—original draft preparation, Y.W.; writing—review and editing, S.G.; funding acquisition, S.G. All authors have read and agreed to the published version of the manuscript." 525 822 W4389385883.pdf 13 5 separator 0.9795351 ¶ 822 824 W4389385883.pdf 13 6 paratext 0.5964984 Funding: This research was funded by the National 824 874 W4389385883.pdf 13 7 text 0.8023262 "Natural Science Foundation of China (No. 52105541), the Basic Research Program of Jiangsu Province (No. BK20200983), the Changzhou Science and Technology Bureau (CQ20210082) and the Postgraduate Research & Practice Innovation Program of Jiangsu Province (SJCX22_1430)." 874 1149 W4389385883.pdf 13 8 separator 0.99199325 ¶ 1149 1151 W4389385883.pdf 13 9 paratext 0.6437393 Institutional Review Board Statement: Not applicable. 1151 1205 W4389385883.pdf 13 10 separator 0.9674925 ¶ 1205 1207 W4389385883.pdf 13 11 paratext 0.58989525 Informed Consent Statement: Not applicable. 1207 1251 W4389385883.pdf 13 12 separator 0.92316616 ¶ 1251 1253 W4389385883.pdf 13 13 paratext 0.5886863 Data Availability Statement: Data are contained 1253 1301 W4389385883.pdf 13 14 bibliography 0.49907884 1301 1302 W4389385883.pdf 13 15 paratext 0.5474602 within the article. 1302 1321 W4389385883.pdf 13 16 separator 0.82763904 ¶ 1321 1323 W4389385883.pdf 13 17 paratext 0.6079581 Conflicts of Interest: The authors declare no conflict of interest. 1323 1389 W4389385883.pdf 13 18 separator 0.99278116 ¶ 1389 1391 W4389385883.pdf 13 19 title 0.6660237 References 1391 1402 W4389385883.pdf 13 20 separator 0.9862766 ¶ 1402 1404 W4389385883.pdf 13 21 bibliography 0.9975086 1. Wang, Y. Laser precision ranging technology. Spacecr. Recovery Remote Sens. 2021 ,42, 22–33. 1404 1500 W4389385883.pdf 13 22 separator 0.7129561 ¶ 1500 1502 W4389385883.pdf 13 23 bibliography 0.998118 "2. Martins, R.J.; Marinov, E.; Youssef, M.A.B.; Kyrou, C.; Joubert, M.; Colmagro, C.; G âté, V .; Turbil, C.; Coulon, P .-M.; Turover, D.; et al. Metasurface-enhanced light detection and ranging technology. Nat. Commun. 2022 ,13, 5724. [CrossRef] [PubMed]" 1502 1760 W4389385883.pdf 13 24 separator 0.9064584 ¶ 1760 1762 W4389385883.pdf 13 25 bibliography 0.9980178 "3. Bae, Y.C. An improved measurement method for the strength of radiation of reflective beam in an industrial optical sensor based on laser displacement meter. Sensors 2016 ,16, 752. [CrossRef]" 1762 1957 W4389385883.pdf 13 26 separator 0.9048505 ¶ 1957 1959 W4389385883.pdf 13 27 bibliography 0.99810654 "4. Qiu, Z.S.; Yang, F.; Ye, X.C.; Li, S.X. Research on Laser Ranging Technology Based on Pseudo-Random Code Phase Modulation and Coherent Detection. Laser Optoelectron. Prog. 2018 ,55, 052801." 1959 2154 W4389385883.pdf 13 28 separator 0.91388804 ¶ 2154 2156 W4389385883.pdf 13 29 bibliography 0.9980508 "5. Pan, Y.L.; Ji, R.Y.; Gao, C.; Zhou, W.H. High-speed phase laser ranging technology based on vector inner product method. Infrared Laser Eng. 2022 ,51, 20210186-1." 2156 2324 W4389385883.pdf 13 30 separator 0.8993192 ¶ 2324 2326 W4389385883.pdf 13 31 bibliography 0.9979907 "6. Zhang, F.M.; Yi, L.P .; Qu, X.H. Simultaneous measurements of velocity and distance via a dual-path FMCW lidar system. Opt. Commun. 2020 ,474, 126066. [CrossRef]" 2326 2493 W4389385883.pdf 13 32 separator 0.89294195 ¶ 2493 2495 W4389385883.pdf 13 33 bibliography 0.9973431 "7. Jiang, S.; Liu, B.; Wang, H.C. FMCW laser ranging method based on a frequency multiplier. Appl. Opt. 2021 ,60, 918–922. [CrossRef] [PubMed]" 2495 2640 W4389385883.pdf 13 34 separator 0.9402257 ¶ 2640 2642 W4389385883.pdf 13 35 bibliography 0.99795413 "8. Lin, C.X.; Wang, Y.F.; Tan, Y.D. Laser Feedback FMCW Ranging System Based on Multiple-Equal-Phase-Subdivision Resampling. J. Light. Technol. 2023 ,41, 2846–2854. [CrossRef]" 2642 2820 W4389385883.pdf 13 36 separator 0.92199147 ¶ 2820 2822 W4389385883.pdf 13 37 bibliography 0.99811137 "9. Ke, J.Y.; Song, Z.Q.; Wang, P .S.; Cui, Z.M.; Mo, D.; Lin, M.; Wang, R.; Wu, J. Long distance high resolution FMCW laser ranging with phase noise compensation and 2D signal processing. Appl. Opt. 2022 ,61, 3443–3454. [CrossRef]" 2822 3055 W4389385883.pdf 13 38 separator 0.8545542 ¶ 3055 3057 W4389385883.pdf 13 39 bibliography 0.9979517 "10. Uysal, F. Phase-coded FMCW automotive radar: System design and interference mitigation. IEEE Trans. Veh. Technol. 2019 ,69, 270–281. [CrossRef]" 3057 3207 W4389385883.pdf 13 40 separator 0.91472816 ¶ 3207 3209 W4389385883.pdf 13 41 bibliography 0.99797 "11. Okano, M.; Chong, C.H. Swept Source Lidar: Simultaneous FMCW ranging and nonmechanical beam steering with a wideband swept source. Opt. Express 2020 ,28, 23898–23915. [CrossRef] [PubMed]" 3209 3402 W4389385883.pdf 13 42 separator 0.9108393 ¶ 3402 3404 W4389385883.pdf 13 43 bibliography 0.9979765 "12. Ula, R.K.; Noguchi, Y.; Iiyama, K. Three-dimensional object profiling using highly accurate FMCW optical ranging system. J. Light. Technol. 2019 ,37, 3826–3833. [CrossRef]" 3404 3581 W4389385883.pdf 13 44 separator 0.947652 ¶ 3581 3583 W4389385883.pdf 13 45 bibliography 0.9980467 "13. Bravo Gonzalo, I.; Dybbro Engelsholm, R.; Peter Sørensen, M.; Bang, O. Polarization noise places severe constraints on coherence of all-normal dispersion femtosecond supercontinuum generation. Sci. Rep. 2018 ,8, 6579. [CrossRef] [PubMed]" 3583 3827 W4389385883.pdf 13 46 separator 0.95189667 ¶ 3827 3829 W4389385883.pdf 13 47 bibliography 0.9978829 "14. Wu, G.H.; Zhou, S.Y.; Yang, Y.T.; Ni, K. Dual comb ranging: Methodologies, systems and applications. In Proceedings of the 2023 Conference on Lasers and Electro-Optics (CLEO), San Jose, CA, USA, 7–12 May 2023. [CrossRef]" 3829 4056 W4389385883.pdf 13 48 separator 0.90643466 ¶ 4056 4058 W4389385883.pdf 13 49 bibliography 0.9979664 15. Wu, G.H.; Zhou, S.Y.; Yang, Y.T.; Kai, N. Dual-comb ranging and its applications. Chin. J. Lasers 2021 ,48, 1504002. 4058 4179 W4389385883.pdf 13 50 separator 0.91486704 ¶ 4179 4181 W4389385883.pdf 13 51 bibliography 0.9980339 "16. Caldwell, E.D.; Sinclair, L.C.; Newbury, N.R.; Deschenes, J.-D. The time-programmable frequency comb and its use in quantum- limited ranging. Nature 2022 ,610, 667–673. [CrossRef]" 4181 4367 W4389385883.pdf 13 52 separator 0.90423 ¶ 4367 4369 W4389385883.pdf 13 53 bibliography 0.99787205 "17. Bell, B. The Use and Calibration of the Kern ME5000 Mekometer ; Proceedings; Stanford Linear Accelerator Center: Menlo Park, CA USA, 1992." 4369 4514 W4389385883.pdf 13 54 separator 0.91550833 ¶ 4514 4516 W4389385883.pdf 13 55 bibliography 0.99801743 18. Meier, D.; Loser, R. The ME5000 Mekometer—A New Precision Distance Meter ; Kern & Co.: Aaray, Switzerland, 1986. 4516 4633 W4389385883.pdf 13 56 separator 0.8618652 ¶ 4633 4635 W4389385883.pdf 13 57 bibliography 0.998023 19. Metrology, L.G. Leica Absolute Tracker AT401, White Paper ; Hexagon AB: Stockholm, Sweden, 2010. 4635 4736 W4389385883.pdf 13 58 separator 0.9105054 ¶ 4736 4738 W4389385883.pdf 13 59 bibliography 0.99798644 "20. Derek, S.; Robert, V .H.; Joseph, S. Polarization and fold mirrors in application of the Leica Absolute Distance Meter. Polariz. Sci. Remote Sens. IV SPIE 2009 ,7461 , 189–197." 4738 4921 W4389385883.pdf 13 0 paratext 0.9901446 Appl. Sci. 2023 ,13, 7264 2 of 18 0 33 W4381251062.pdf 1 1 separator 0.99412096 ¶ 33 35 W4381251062.pdf 1 2 text 0.99958354 "compared with traditional methods, they are time-consuming and often fail to meet the real- time requirements for target detection tasks. Among the above algorithms, the dark channel prior theory [ 18] based on the atmospheric scattering model is more effective, has higher detection accuracy, and fast running speed. Thus, it is adopted in this paper to achieve the effect of defogging by incorporating the method into the target detection network." 35 493 W4381251062.pdf 1 3 separator 0.96757925 ¶ 493 495 W4381251062.pdf 1 4 text 0.999635 "Target detection algorithms can be divided into two categories according to the pres- ence or absence of a preset anchor frame as a benchmark: anchor-free methods and anchor- based methods. Anchor-free algorithms mainly include ConerNet [ 19], CenterNet [ 20], FCOS [ 21], etc., and anchor-based mainly include YoLo series [ 22], SSD [ 23], RetinaNet [ 24], etc. Since anchor-based methods require setting different anchor frames in different datasets, and the setting of anchor frames will have an impact on the accuracy, non-extreme value suppression is also required, resulting in slow running speed [ 25]. To address the above drawbacks, anchor-free target detection algorithms have been gradually developed. For CenterNet networks, anchor-free algorithms treat a target as a point, and one target is determined using one feature point. Its prediction result will divide the input image into different regions, and each region will have one feature point. Then, it will be determined whether an object exists or not in each feature point, as well as its type and confidence, according to the prediction result. The algorithms will also adjust the feature point to obtain the center coordinates and the width and height of the object." 495 1758 W4381251062.pdf 1 5 separator 0.98353946 ¶ 1758 1760 W4381251062.pdf 1 6 text 0.99972016 "Currently, target detection methods in foggy environments can be mainly divided into two categories: a two-stage method and an end-to-end approach. The two-stage method is an uncorrelated target detection method based on defogging detection. It defogs the fogged image using image enhancement and recovery methods and then detects the defogged image using target detection methods. The defogging process may bring problems such as artifacts, color distortion, and fog residue to the image, so not all images detected using defogging methods will improve their detection accuracy. The end-to-end approach, on the other hand, jointly optimizes the training of the defogging network and the target detection network to perform the defogging task and the detection task simultaneously [ 26–28] to solve the above problems. Therefore, this paper adopts an end-to-end approach to detect targets in foggy scenes to improve detection accuracy." 1760 2716 W4381251062.pdf 1 7 separator 0.97715926 ¶ 2716 2718 W4381251062.pdf 1 8 text 0.9995017 "As we all know, it is essential to construct the high-resolution foggy insulator image datasets taken by UAVs, then to locate and detect the “self-exposure” areas of insulators with the help of image-processing and deep-learning technologies to realize intelligent power inspection. As stated above, to address the challenges of foggy environment target detection, this paper proposes a joint learning framework Dark-Center foggy insulator detection and identification algorithm based on CenterNet, which is called Dark-Center detection for short. Its characteristics are outlined as follows:" 2718 3322 W4381251062.pdf 1 9 separator 0.9710126 ¶ 3322 3324 W4381251062.pdf 1 10 text 0.9914439 "1. Due to the lack of large-scale foggy insulator datasets, this paper builds foggy image dataset CPILDs using the haze simulation method to construct insulator haze images; 2. To address the problem of poor robustness of most current defogging algorithms, this paper proposes a novel image-defogging algorithm with an optimized defogging and repairing process; 3. The Center algorithm is proposed to enhance the detection capability of small insu- lators to solve the problem of insufficient feature extraction capability of the detec- tion network; 4. This paper jointly optimizes the training of the defogging algorithm and the tar- get detection algorithm to overcome the problems of artifacts, color distortion, and fog residue." 3324 4077 W4381251062.pdf 1 11 separator 0.996155 ¶ 4077 4079 W4381251062.pdf 1 12 title 0.993904 2. Construction of Foggy Insulator Datasets CPILDs 4079 4130 W4381251062.pdf 1 13 separator 0.9954599 ¶ 4130 4132 W4381251062.pdf 1 14 text 0.99961644 "Since there is no publicly available insulator dataset for foggy environments, this paper needs to construct a foggy insulator target detection dataset first, called CPILDs." 4132 4307 W4381251062.pdf 1 0 paratext 0.98089665 Open Peer Review on Qeios 0 25 W4391814229.pdf 0 1 separator 0.93954396 ¶ 25 27 W4391814229.pdf 0 2 title 0.9733043 "Provide reduced frequency of positive consequence for behaviour BCT" 27 97 W4391814229.pdf 0 3 separator 0.7832339 ¶ 97 99 W4391814229.pdf 0 4 title 0.9109242 Behaviour Change Intervention Ontology (BCIO) 99 145 W4391814229.pdf 0 5 separator 0.98385835 ¶ 145 147 W4391814229.pdf 0 6 contact 0.35198358 Source 147 154 W4391814229.pdf 0 7 separator 0.6645107 ¶ 154 156 W4391814229.pdf 0 8 contact 0.39240098 Behaviour Change Intervention Ontology ( 156 197 W4391814229.pdf 0 9 text 0.4056071 BCIO 197 201 W4391814229.pdf 0 10 contact 0.3329643 ) 201 202 W4391814229.pdf 0 11 separator 0.96461403 ¶ 202 204 W4391814229.pdf 0 12 text 0.80521345 Definition: 204 216 W4391814229.pdf 0 13 separator 0.5924587 ¶ 216 218 W4391814229.pdf 0 14 text 0.98209554 "A provide positive consequence for behaviour BCT that provides the consequence at increasingly less frequent intervals. ¶ This definition was imported from the Behaviour Change Intervention Ontology (see https://bciosearch.org/ ). Comments and suggestions for improvements are welcome using the Qeios review system. ¶ Definitions imported from the Behaviour Change Intervention Ontology (BCIO) are what are known as ‘ontological definitions’. See this article in Qeios for an explanation https://www.qeios.com/read/YGIF9B . ¶ Ontological definitions can sometimes be hard to read. In those cases we also include an informal definition. ¶ Definitions also often require elaboration to make it clear how they should be used and what they include. In those cases we include a comment. ¶ Also, definitions sometimes require an explanation as to how they came about to help users understand how they relate to alternative definitions. In those cases we include a curator note." 219 1231 W4391814229.pdf 0 15 separator 0.98358124 ¶ 1231 1233 W4391814229.pdf 0 16 paratext 0.95966125 "Qeios · Definition, February 14, 2024" 1233 1278 W4391814229.pdf 0 17 separator 0.6168798 ¶ 1278 1280 W4391814229.pdf 0 18 paratext 0.94182914 "Qeios ID: 8VT77T.2 · https://doi.org/10.32388/8VT77T.2 1 / 1" 1280 1351 W4391814229.pdf 0 0 text 0.99896574 "acquisitions were required for lesion targeting, signifi- cantly reducing radiation dose by 54% and procedural time by mean 24 min (minus 42%, non-significant likely due to small sample size). Similar advantages have been described in prior thermal ablation studies [ 22–24]." 0 283 W2961492059.pdf 4 1 separator 0.9648489 ¶ 283 285 W2961492059.pdf 4 2 text 0.99959856 "These benefits are likely to be the result of the nearly static PAVMs, and for this reason, diaphragmatic excur- sion was compared with a historic series of 10 patients undergoing the same procedure using IPPV. As ex- pected, HFJV-assisted cases demonstrated significantly lower diaphragmatic excursion compared to IPPV (mean 1.3 mm, compared with 20 mm for IPPV), and similar results (1.3 mm excursion with HFJV assistance com- pared with 11 mm for IPPV) were observed intraproce- durally in the five cases with HFJV assistance, although did not reach statistical significance likely due to small sample size. These measurements are comparable with reported excursion of 1 –3 cm during quiet breathing and conventional IPPV [ 29,30] and with prior studies reporting reduced diaphragmatic motion during HFJV- assisted extracorporeal shockwave lithotripsy [ 25]." 285 1177 W2961492059.pdf 4 3 separator 0.94675684 ¶ 1177 1179 W2961492059.pdf 4 4 text 0.9996341 "Although direct, reliable/reproducible measurement of PAVM motion was not possible due to retrospective differences in projections/positioning between cases, diaphragmatic excursion was considered an adequate surrogate, since it was less prominently affected by inter- procedural factors, and appears to be similar in magni- tude to whole-lung movement during respiration [ 31]." 1179 1570 W2961492059.pdf 4 5 separator 0.9735055 ¶ 1570 1572 W2961492059.pdf 4 6 text 0.9996672 "The present measurement of 1.3 mm is comparable to prior reports of HFJV-assisted thermal ablation and radiotherapy procedures. Denys et al. [ 21] measured tar- get tumour displacement during lung, liver, and renal tumour ablation using CT guidance and demonstrated a mean motion of 0.3 mm transversely and < 3.75 mm cranio-caudally. Biro et al. [ 20] reported a reduction in liver motion from 20 to 5 mm following switching from IPPV to HFJV, and liver motion < 3 mm has been reported during HFJV-assisted hepatic radiotherapy using fiducial markers [ 22]. Diaphragmatic excursion is therefore min- imal compared with gross motion using standard IPPVtidal volumes [ 18], and HFJV assistance appears to provide effective respiratory immobilisation." 1572 2345 W2961492059.pdf 4 7 separator 0.9750047 ¶ 2345 2347 W2961492059.pdf 4 8 text 0.9995809 "HFJV assistance appeared to be safe, with no episodes of desaturation, hypercapnia, or barotrauma. One patient experienced bronchospasm requiring temporary conver- sion to IPPV; however, this was due to insufficient depth of anaesthesia, and HFJV was promptly recommenced following additional anaesthetic administration. There were no differences in technical success/outcomes com- pared with IPPV. Use of current-generation systems (which continuously monitor airway pressure with an alarm signal to avoid barotrauma) and intermittent CO 2 monitoring with HFJV further increases procedural safety [ 14]. HFJV also proved practical and widely applic- able, with simple/user-friendly ventilator installation and few contra-indications (COPD with forced expiratory volume in the first second < 1500 mL, severe obesity, and recent pneumothorax/thoracic surgery [ 32]). How- ever, the need for specially trained anaesthesiology teams, and potentially longer anaesthetic times are as- pects that should be taken into account [ 14,21,23,24]." 2347 3419 W2961492059.pdf 4 9 separator 0.98225623 ¶ 3419 3421 W2961492059.pdf 4 10 text 0.99957705 "Study limitations include small sample size, including only few patients undergoing PAVM embolisation under general anaesthesia, and short follow-up, limiting gener- alisability and outcome comparison. Groups were non- randomised, but there were no significant differences in demographics, lesions, and embolisation devices. Pro- cedural duration did not include anaesthetic time, and there was no evaluation of anaesthesiologist technical difficulty due to the retrospective protocol. Finally, diaphragmatic excursion was used as a surrogate for PAVM motion and measured using a gross method. Al- though non-comparable to standardised diaphragmatic measurements and without proven correlation with PAVM motion, this was sufficient to illustrate significant relative motion reduction with HFJV assistance com- pared with IPPV." 3421 4278 W2961492059.pdf 4 11 separator 0.89266574 ¶ 4278 4280 W2961492059.pdf 4 12 text 0.99900085 "In conclusion, in patients undergoing PAVM embolisa- tion under general anaesthesia, HFJV-assisted embolisa- tion is a safe, practical technique enabling respiratory" 4280 4450 W2961492059.pdf 4 13 title 0.9848997 Table 1 Patient demographics, symptoms, and PAVMs treated in groups A and B 4450 4525 W2961492059.pdf 4 14 separator 0.9796971 ¶ 4525 4527 W2961492059.pdf 4 15 table 0.9944709 "Group Number of patientsDemographics Symptoms Number of PAVMs treatedPAVM locationEmbolisation devices A (HFJV) 5 Age 47.2 ± 11.7 years (34–57 years) 2 males, 3 females4/5 (80%) 1 prior TIA 3 dyspnoea12 simple RLL ( n=4 ) RML ( n=1 ) RUL ( n=1 ) LLL ( n=4 ) LUL ( n=2 )6.5-mm MVP ( n= 4), vascular plug ( n= 5), coils ( n=3 ) B (IPPV) 10 Age 41.5 ± 12.4 years (27–65 years) 5 male, 5 female7/10 (70%) 1 prior TIA 6 dyspnoea15 (14 simple, 1 complex)RLL ( n=3 ) RML ( n=5 ) RUL ( n=2 ) LLL ( n=3 ) LUL ( n=2 )6.5-mm MVP ( n= 4), vascular plug ( n= 3), coils ( n=8 )" 4527 5139 W2961492059.pdf 4 16 separator 0.95877385 ¶ 5139 5141 W2961492059.pdf 4 17 table 0.94752663 "Ages are given as mean ± standard deviation (range). HFJV High-frequency jet ventilation, IPPV Intermittent positive pressure ventilation, LLL/LUL Left lower/upper lobes, MVP Microvascular plug, RLL/RML/RUL Right lower/middle/ upper lobes, TIATransient ischemic attack" 5141 5412 W2961492059.pdf 4 18 paratext 0.9372352 Boatta et al. European Radiology Experimental (2019) 3:26 Page 5 of 7 5412 5492 W2961492059.pdf 4 0 paratext 0.9637831 VARIOUS AUTHORS 551 0 19 W4233859333.pdf 0 1 separator 0.99136555 ¶ 19 21 W4233859333.pdf 0 2 text 0.99942416 "slowing down o f micro-organism activity caused an increase in litter buildup. However, this meant that the percentage taken by termites was increased, and this percentage was instantly reduced to NH (another assumption o f model). Thus NH increased because o f greater input. NU rose because although the rate o f transfer from NH to NU was slower, the larger amount o f NH still meant that a greater amount o f NU was produced. The HA level increased slightly because the rate o f flow from HA to NU (not termite affected) was slower." 21 598 W4233859333.pdf 0 3 separator 0.97115815 ¶ 598 600 W4233859333.pdf 0 4 text 0.9995503 "It was found that the conceptualization o f decompo­ sition processes in a modelling framework, albeit very crude, gave direction and common goals to the researchers participating in this component o f the Savanna Ecosystem Project. It improved communi­ cation between individual participants and gave fieldworkers an insight into the data requirements of models. Examples which support these statements follow. Litter collected monthly from the study area is being analysed for the five chemical fractions into which it was classified, as well as for other fractions." 600 1205 W4233859333.pdf 0 5 separator 0.87571275 ¶ 1207 1209 W4233859333.pdf 0 6 text 0.9994779 "From the results o f these analyses a more meaningful breakdown will be included in the next version o f the model. These results will also be used for model validation. A pilot project, started to establish the annual course o f leaf and dead wood fall, is being expanded because the importance o f litter fall was highlighted by the model. Cooperation between the researcher studying termites and the microbiologist has become more meaningful now that possible decomposition pathways including both termites and micro-organisms have been identified. Research is nowaimed at trying to either confirm the assumptions made in this model about the relative roles o f termites and micro-organisms or produce new assumptions based on sounder knowledge." 1209 2011 W4233859333.pdf 0 7 separator 0.9486563 ¶ 2011 2013 W4233859333.pdf 0 8 text 0.9993484 "The results presented above are o f limited value as they were based on some invalid assumptions and on transfer rates derived from temperate region studies rather than from the study site itself. Although the assumptions are being revised, the model is being re-structured, transfer rates are being derived from Nylsvley experiments (Fig. 6) and literature is being reviewed at present, we consider that this short Note on progress to date with the first South African decomposition model is appropriate." 2013 2555 W4233859333.pdf 0 9 separator 0.9963933 ¶ 2555 2557 W4233859333.pdf 0 10 title 0.9830443 REFERENCES 2557 2568 W4233859333.pdf 0 11 separator 0.9943485 ¶ 2568 2570 W4233859333.pdf 0 12 bibliography 0.9915832 "A u sm u s, B. S. & W itk a m p , M., 1975. Litter and soil microbial dynamics in a deciduous forest stand. Tennessee, Oak Ridge National Laboratories Pub." 2570 2735 W4233859333.pdf 0 13 separator 0.8907422 ¶ 2735 2737 W4233859333.pdf 0 14 bibliography 0.9904566 "C o e tz e e , B. J., V a n D e r M e u le n , F., Z w a n z ig e r , S., G o n s a l ­ ves, P. & W e is s e r , P., 1976. A phytosociological classi­ fication of the Nylsvley Nature Reserve. Bothalia 12: 137— 160." 2737 2964 W4233859333.pdf 0 15 separator 0.9867711 ¶ 2964 2966 W4233859333.pdf 0 16 bibliography 0.98827 "M o r r i s , J. W. (ed.), 1977. First modelling workshop—January 1977. Pretoria. Unpublished report of the Savanna Eco­ system Project." 2966 3111 W4233859333.pdf 0 17 separator 0.98394185 ¶ 3111 3113 W4233859333.pdf 0 18 contact 0.98643416 "J. W. Mo r r is *, J. Bezu id en h o u t **, P. Fe r r a r I, J. C h arm ain e HoRNEf an d M . Ju d e l m a n | * Botanical Research Institute, Department of Agricultural Technical Services, Private Bag X101, Pretoria. ** University of Pretoria, Pretoria, t University of the Witwatersrand, Johannesburg." 3113 3435 W4233859333.pdf 0 19 separator 0.99406826 ¶ 3435 3437 W4233859333.pdf 0 20 title 0.99439996 A TABLE OF MAXIMUM ENTROPY VALUES FOR THE ECOLOGICAL PROFILES TECHNIQUE 3437 3510 W4233859333.pdf 0 21 separator 0.99511766 ¶ 3510 3512 W4233859333.pdf 0 22 text 0.9994731 "Use o f the ecological profiles technique (Morris & Guillerm, 1974) in South Africa is hindered by the absence o f a table of maximum entropy values. These values are required for the calculation o f sampling equitability o f variables. The shortcoming is remedied by this Note which provides Im ax for values o f K from one to 50 in Table 1 (notation follows Morris & Guillerm, 1974). Thus a variable with five classes, after grouping when necessary, has an Im ax o f 2,322." 3512 4023 W4233859333.pdf 0 23 separator 0.9954464 ¶ 4023 4025 W4233859333.pdf 0 24 table 0.9943107 "TABLE 1.— Maximum entropy values corresponding to 50 values of K K Im ax K Im ax 1................ 0,000 16................. 4,000 2................. 1,000 17................. 4,087 3................. 1,585 18................. 4,170 4................. 2,000 19................. 4,248 5................. 2,322 20................. 4,322 6................. 2,585 21 ................. 4,392 7................. 2,807 22................. 4,459 8................. 3,000 23................. 4,524 9................. 3,170 24 ................. 4,585 10................. 3,322 25................. 4,644 11................. 3,459 26................. 4,700 12................. 3,585 27................. 4,755 13................. 3,700 28................. 4.807 14................. 3,807 29................. 4,858 15................. 3,907 30................. 4,907K Im ax K Im ax 31................. 4,954 41................. 5,358 32................. 5,000 42 ................. 5,392 33................. 5,044 43................. 5,426 34................. 5,087 44 ................. 5,459 35................. 5,129 45 ................. 5,492 36................. 5,170 46................. 5,524 37................. 5,209 47................. 5,555 38................. 5,248 48................. 5,585 39................. 5,285 49................. 5,615 40................. 5,322 50................. 5,644" 4025 5472 W4233859333.pdf 0 25 separator 0.9814998 ¶ 5472 5474 W4233859333.pdf 0 26 text 0.93020993 Maximum entropy o f factor L is calculated as: 5474 5521 W4233859333.pdf 0 27 separator 0.41606453 ¶ 5521 5523 W4233859333.pdf 0 28 math 0.6782104 "Im ax » L = l0ë2^-""" 5523 5545 W4233859333.pdf 0 29 separator 0.48216462 ¶ 5545 5547 W4233859333.pdf 0 30 text 0.948943 "For values of K greater than 50 the following formula should be used to calculate maximum entropy:" 5547 5650 W4233859333.pdf 0 31 separator 0.49686575 ¶ 5650 5652 W4233859333.pdf 0 32 math 0.8752663 "Im ax, L= logioK.(logi02) 1 = lo g 10K. 3,3 22" 5652 5701 W4233859333.pdf 0 33 separator 0.99344444 ¶ 5703 5705 W4233859333.pdf 0 34 title 0.84633225 REFERENCE 5705 5715 W4233859333.pdf 0 35 separator 0.98929185 ¶ 5715 5717 W4233859333.pdf 0 36 bibliography 0.9932996 "M o r r i s , J. W. & G u i ll e r m , J. L., 1974. The ecological profiles technique applied to data from Lichtenburg, South Africa. Bothalia 11: 355-364." 5717 5883 W4233859333.pdf 0 37 separator 0.6622571 ¶ 5883 5885 W4233859333.pdf 0 38 bibliography 0.5032689 J. W . M o r 5885 5898 W4233859333.pdf 0 39 paratext 0.36044183 5898 5899 W4233859333.pdf 0 40 bibliography 0.39918277 r 5899 5900 W4233859333.pdf 0 41 paratext 0.41204876 is 5900 5903 W4233859333.pdf 0 42 separator 0.98775434 ¶ 5903 5905 W4233859333.pdf 0 43 title 0.99396676 A FIRST ATTEMPT TO MEASURE TEMPERATURES OF FIRE IN FYNBOS 5905 5964 W4233859333.pdf 0 44 separator 0.9935329 ¶ 5964 5966 W4233859333.pdf 0 45 text 0.9994592 "Veld fire research is being conducted in Cape mountain fynbos, Acocks’s (1975) Veld Types 69 and 70, to determine the effect o f fire on vegetation and streamffow and to establish how fire should be used in managing catchments. As previous workers (Ken­ worthy, 1963; West, 1965; and Kayll, 1966) have pointed out, one o f the most important things to knowabout fire is its intensity as expressed by its tempera­ ture duration. This may be measured accurately but expensively with thermocouples (Kenworthy, 1963; Kayll, 1966), or indirectly by recording the water loss from blackened metal canisters (Beaufait, 1966)." 5966 6620 W4233859333.pdf 0 46 separator 0.76705205 ¶ 6622 6624 W4233859333.pdf 0 47 text 0.9966011 "Where inadequate resources preclude duration measurements, temperature measurements alone must" 6624 6723 W4233859333.pdf 0 48 separator 0.7541061 ¶ 6723 6725 W4233859333.pdf 0 0 paratext 0.9579629 1 0 1 W2762885485.pdf 0 1 separator 0.9084097 "¶ ¶ ¶" 2 21 W2762885485.pdf 0 2 title 0.7660069 Non-predictive online spatial coding in the posterior parietal cortex when aiming ahead 21 109 W2762885485.pdf 0 3 separator 0.9503373 ¶ 110 112 W2762885485.pdf 0 4 title 0.64236593 for catching 112 125 W2762885485.pdf 0 5 separator 0.9667423 ¶ ¶ 126 132 W2762885485.pdf 0 6 contact 0.9906629 "Sinéad A. Reid & Joost C. Dessing* ¶ School of Psychology Queen’s University Belfast David Keir Building, 18-30 Malone Road BT9 5BN Belfast Northern Ireland ¶ sreid33@qub.ac.uk Tel: 0044- 28-90974558 j.dessing@qub.ac.uk Tel: 0044- 28-90975650" 132 410 W2762885485.pdf 0 7 separator 0.82223755 ¶ 411 416 W2762885485.pdf 0 8 paratext 0.64355725 . CC-BY 4.0 International license available under anot certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint ( 416 643 W2762885485.pdf 0 9 text 0.47995058 which 643 648 W2762885485.pdf 0 10 paratext 0.7687776 was this version posted October 4, 2017. ; https://doi.org/10.1101/197160doi: bioRxiv preprint 648 743 W2762885485.pdf 0 0 paratext 0.9786944 "Sayed Amin Mohamed Amer et al . / American Journal of Biochemistry and Biotechnology 2018, 14 (1): 61.66 DOI: 10.3844/ajbbsp.2018.61.66" 0 139 W2791097848.pdf 2 1 separator 0.8819741 ¶ ¶ 140 146 W2791097848.pdf 2 2 paratext 0.77336055 63 146 149 W2791097848.pdf 2 3 title 0.8978003 Table 1: Sequence variations in cytb gene compared to Andrew s sequence. The 150 228 W2791097848.pdf 2 4 table 0.31883326 variations 228 238 W2791097848.pdf 2 5 title 0.45989105 are listed when they wer e polymorphic 238 277 W2791097848.pdf 2 6 table 0.29374185 ¶ 278 280 W2791097848.pdf 2 7 title 0.30232108 ( 280 282 W2791097848.pdf 2 8 table 0.3320816 found in more than one individual 282 315 W2791097848.pdf 2 9 caption 0.62897813 ). The reference stands in bold for Andrews sequence. Numbers on the top indicate 315 397 W2791097848.pdf 2 10 table 0.5364027 ¶ 398 400 W2791097848.pdf 2 11 caption 0.5775875 nucleotide position in whole mit 400 433 W2791097848.pdf 2 12 table 0.42666748 ochondri 433 441 W2791097848.pdf 2 13 caption 0.4746615 al genome 441 450 W2791097848.pdf 2 14 table 0.46635458 450 451 W2791097848.pdf 2 15 caption 0.5360969 a nd dots (.) represent matches with the reference se quence. 451 512 W2791097848.pdf 2 16 table 0.4839719 Haplotypes ¶ 512 526 W2791097848.pdf 2 17 caption 0.46700096 sharing the same nucleotide at 526 557 W2791097848.pdf 2 18 table 0.5171367 557 558 W2791097848.pdf 2 19 caption 0.57012 a certain position 558 576 W2791097848.pdf 2 20 table 0.39617798 576 577 W2791097848.pdf 2 21 caption 0.43205178 a re 577 581 W2791097848.pdf 2 22 table 0.48534167 listed together 581 597 W2791097848.pdf 2 23 separator 0.899981 ¶ 598 600 W2791097848.pdf 2 24 table 0.9903338 "Sharing haplotypes 14905 15043 15218 15235 15257 15 262 15301 15326 15431 15452 15466 15607 15674 15677 15679 15784 rCRS G G A A G T G A G C G A T A A T H6, H33, H65 A . . . . . . G . A . G . . . . H11, H15, H53, H54 . A . . . . A G . . . . . . . . H8, H47 . . . G . . . G . . . . . . . . H15, H27, H49 . . . . . . . G A . . . . . . . H26, H32 . . G . . . . G . . . . . . . . H10, H16, H48, . . . . A . . G . A . . . . G . H51, H61, H66 H29, H46 . . . . . C . . . . . . . . . . H1-H3, H5, H8, . . . . . . A G . . . . . . . . H11, H14, H15, H18, H29, H35-H39, H40-H42, H46, H53, H54 H4, H6, H10, H16, . . . . . . . G . A . . . . . . H20-H22, H31, H33, H40, H43-H45, H48, H51, H55-H57, H61-H63, H65- H66 H31, H40, H55, H57, H60 . . . . . . . . . . A . . . . . H24, H25, H28, H60 . . . . . . . G . . . . C . . . H48, H51 . . . . . . . G . A . . . C . . H14, H26, H41, H42 . . . . . . . G . . . . . . . C" 600 1580 W2791097848.pdf 2 25 separator 0.97282785 ¶ ¶ 1581 1587 W2791097848.pdf 2 26 title 0.9558742 Table 2: Amino acid changes as a result of 26 nucleotide sub stitutions 1587 1659 W2791097848.pdf 2 27 separator 0.9811052 ¶ 1661 1663 W2791097848.pdf 2 28 table 0.99427575 "Reference nucleotide Position in position Substitution Individuals Amino acid the co don Synonymous 14905 G-A H6, H33, H65 Met-met 3 + 14981 A-C H27 Ile-Leu 1 - 15043 G-A H11, H15, H53, H54 Gly-Gly 3 + 15110 G-A H18 Ala-Thr 1 - 15136 C-T H27 Gly-Gly 3 + 15148 G-A H19 Pro-Pro 3 + 15217 G-A H18 Gly-Gly 3 + 15218 A-G H26, H32 Thr-Ala 1 - 15229 T-C H32 Val-Val 3 + 15235 A-G H8, H47 Trp-Trp 3 + 15257 G-A H10, H16, H48, H51, H61, H66 Asp-Asn 1 - 15262 T-C H29, H46 Ser-Ser 3 + 15301 G-A H1-H3, H5, H8, H11, H14, H15, H18, Leu-Le u 3 + H29, H35-H39, H40-H42, H46, H53, H54 15326 A-G all except H19 Thr-Ala 1 - 15358 A-G H5 Gly-Gly 3 + 15388 T-C H29, H46 His-His 3 + 15431 G-A H15, H27, H49 Ala-Thr 1 - 15452 C-A H4, H6, H10, H16, H20-H22, H31, H33, Leu- Ile 1 - H40, H43-H45, H47, H50-H53, H55-H56, H58, H61-H63, H66 15466 G-A H31, H40, H55, H57, H60 Met-met 3 + 15514 T-C H8 Tyr-Tyr 3 + 15607 A-G H6, H33, H65 Lys-Lys 3 + 15674 T-C H24, H25, H28, H60 Ser-Pro 1 - 15677 A-C H48, H51 Gln -Lys 1 - 15679 A-G H10, H16, H48, H51, H61, H66 Lys-Lys 3 + 15746 A-G H13 Ile-Val 1 - 15784 T-C H14, H26, H41, H42 Pro-Pro 3 +" 1663 2880 W2791097848.pdf 2 0 paratext 0.98427534 "Meizarini et al Trop J Pharm Res, February 2018; 17(2): 272" 0 63 W2794147783.pdf 3 1 separator 0.8436935 ¶ 64 66 W2794147783.pdf 3 2 text 0.9868645 "was the Santa Cruz Biotechnology Kit (Santa Cruz Biotechnology, Dallas, USA), while all intra - step dilution and/or washing was performed using phosphate buffer saline (PBS) unless otherwise specified." 67 282 W2794147783.pdf 3 3 separator 0.9888991 ¶ ¶ 284 290 W2794147783.pdf 3 4 title 0.98899746 Statistical analysis 290 311 W2794147783.pdf 3 5 separator 0.96000546 ¶ 314 316 W2794147783.pdf 3 6 text 0.99209845 "¶ The results were analyzed using SPSS ver. 21 (IBM, New York, USA). A one -way Analysis of Variance (ANOVA) test followed by a least significant difference (LSD) test were applied to assess statistical differences between the study groups at p < 0.05." 318 587 W2794147783.pdf 3 7 separator 0.990938 ¶ ¶ 589 595 W2794147783.pdf 3 8 title 0.9910136 RESULTS 595 603 W2794147783.pdf 3 9 separator 0.97139055 ¶ ¶ 605 611 W2794147783.pdf 3 10 title 0.9754406 In silico data 611 627 W2794147783.pdf 3 11 separator 0.7387503 ¶ 628 633 W2794147783.pdf 3 12 text 0.9972412 "¶ An in silico study was conducted to quantity the minimum energy of the curcumin, demethoxycurcumin , bisdemethoxycurcumin, eugenol, and diclofenac molecule ligands which were predicted to possess COX -2 inhibiting properties. All steps featured the use of ligands in 3D form. ¶ A cavity in the receptor structure (1PXX) was detected, while a diclofenac ligand wa s found in the fifth cavity, where the curcumin, demethoxycurcumin , bisdemethoxycurcumin , eugenol ligand (in 3D form) interacted. The 2D interaction of curcumin with COX -2 receptor resulting in two active methoxy groups, one hydrogen bond (Tyr 355) and 11 steric interactions (Tyr385, Leu384, 2 Val523, 2 Ser353, Val116, Val349, 2 Met113, Leu531) can be seen in Figure 1. The 2D interaction of demethoxycurcumin with the COX -2 receptor produced one active methoxy group, one hydrogen bond (Tyr355) and nine steri c interactions (2 Leu384, Val523, 2 Met113, 2 Val349, 2 Leu531). These can all be seen in ¶" 633 1678 W2794147783.pdf 3 13 caption 0.9577238 "Figure 2. The 2D interaction of bisdemethoxycurcumin with COX -2 receptor which produced one hydrogen bond (His90) and 10 steric interactions (2 Val349, 3 Leu531, 2 Val523, Ala516, Phe518, Leu352) can be seen in Figure 3. The 2D interaction of diclofenac with COX -2 receptor had two hydrogen bonds (Tyr385, Ser530) and 4 steric interactions (Tyr385, Ser353, Tyr355, Met522)." 1678 2079 W2794147783.pdf 3 14 text 0.9403883 "The 2D interaction of eugenol with the COX -2 rec eptor had only 1 hydrogen bond (Met522) with no steric interaction (Figure 4 )." 2079 2218 W2794147783.pdf 3 15 separator 0.94783854 "¶ ¶ ¶" 2219 2233 W2794147783.pdf 3 16 caption 0.9681317 "Figure 1: The 2D form of curcumin interaction with COX -2 receptors contains two active methoxy groups (red arrow), one hydrogen bond (white arrow) and 11 steric interactions (yellow arrow) ¶" 2233 2442 W2794147783.pdf 3 17 separator 0.7394423 ¶ ¶ 2444 2450 W2794147783.pdf 3 18 caption 0.9675641 "Figure 2: The 2D form of demethoxycurcumin interaction with COX -2 receptors contains one active methoxy group (red arrow), one hydrogen bond (white arrow) and nine steric interactions (yellow arrow) ¶" 2450 2668 W2794147783.pdf 3 19 separator 0.70102024 ¶ ¶ 2670 2676 W2794147783.pdf 3 20 caption 0.94897133 "Figure 3: The 2D form interaction of bisdemethoxycurcumin with COX -2 receptors contains one hydrogen bond (white arrow) and ten steric interactions (yellow arrow) ¶ ¶" 2676 2863 W2794147783.pdf 3 21 separator 0.7996555 ¶ 2865 2867 W2794147783.pdf 3 22 caption 0.99505574 "Figure 4: The 2D form of eugenol interaction with COX -two receptors contains one hydrogen bond (white arrow)" 2867 2984 W2794147783.pdf 3 23 separator 0.9961252 ¶ 2986 2988 W2794147783.pdf 3 0 bibliography 0.6825712 Wu et al. 0 9 W4303182909.pdf 2 1 paratext 0.895359 /one.tnum/zero.tnum./three.tnum/three.tnum/eight.tnum/nine.tnum/fnmol./two.tnum/zero.tnum/two.tnum/two.tnum./one.tnum/zero.tnum/five.tnum/one.tnum/three.tnum/three.tnum/five.tnum 9 188 W4303182909.pdf 2 2 separator 0.9833058 ¶ 188 190 W4303182909.pdf 2 3 text 0.9971738 "pain and diabetic peripheral neuropathic pain, respectively, and provided an analytical method to visualize the trend and frontiers of the above fields. Finally, Yang et al. summarized the research progress of non-invasive brain stimulation (NIBS) in the treatment of different central neuropathic pain (CNP)s and described the effects on alleviating CNPs as well as the underlying mechanisms. It is suggested that the future research should gradually carry out large-scale multi center research to verify the stability and reliability of the analgesic effect induced byNIBS." 190 780 W4303182909.pdf 2 4 separator 0.99254787 ¶ 780 782 W4303182909.pdf 2 5 text 0.9915952 "To sum up, this paper on the topic “ Neural Networks and Regulatory Mechanisms Associated with Pain ” expands the mechanistic theories, biomarkers and targeted drugs at the neuralnetworkandmolecularlevelsinthefieldofpain." 782 1009 W4303182909.pdf 2 6 separator 0.99656 ¶ 1009 1011 W4303182909.pdf 2 7 title 0.9780907 Author contributions 1011 1032 W4303182909.pdf 2 8 separator 0.99259025 ¶ 1032 1034 W4303182909.pdf 2 9 text 0.97340024 "All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it forpublication." 1034 1164 W4303182909.pdf 2 10 title 0.92574126 Acknowledgments 1164 1179 W4303182909.pdf 2 11 separator 0.9775156 ¶ 1179 1181 W4303182909.pdf 2 12 text 0.97815055 "We deeply thank all the authors and reviewers who have participatedinthisResearchTopic." 1181 1271 W4303182909.pdf 2 13 separator 0.9959196 ¶ 1271 1273 W4303182909.pdf 2 14 title 0.9796355 Conflict of interest 1273 1293 W4303182909.pdf 2 15 separator 0.98367155 ¶ 1293 1295 W4303182909.pdf 2 16 text 0.9940053 "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could beconstruedasapotentialconflictofinterest." 1295 1463 W4303182909.pdf 2 17 separator 0.995877 ¶ 1463 1465 W4303182909.pdf 2 18 title 0.9752101 Publisher’s note 1465 1482 W4303182909.pdf 2 19 separator 0.98393655 ¶ 1482 1484 W4303182909.pdf 2 20 text 0.9866817 "All claims expressed in this article are solely those of the authorsanddonotnecessarilyrepresentthoseoftheiraffiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed orendorsedbythepublisher." 1484 1826 W4303182909.pdf 2 21 separator 0.99598706 ¶ 1826 1828 W4303182909.pdf 2 22 title 0.9115713 References 1828 1839 W4303182909.pdf 2 23 separator 0.9852636 ¶ 1839 1841 W4303182909.pdf 2 24 bibliography 0.99803776 "Belinskaia, D. A., Belinskaia, M. A., Barygin, O. I., Vanchako va, N. P., and Shestakova,N.N.(2019).Psychotropicdrugsforthemanagem entofchronicpain anditch.Pharmaceuticals 12:99.doi:10.3390/ph12020099" 1841 2046 W4303182909.pdf 2 25 separator 0.96371394 ¶ 2046 2048 W4303182909.pdf 2 26 bibliography 0.99495244 "Caccavale, S., Bove, D., Bove, R. M. (2016). Skin and brain: it ch and psychiatric disorders. G. Ital. Dermatol. Venereol . 151, 525–529. Available online at: https://www.minervamedica.it/en/journals/Ital-J-Dermat ol-Venereol/ article.php?cod=R23Y2016N05A0525" 2048 2314 W4303182909.pdf 2 27 separator 0.98750466 ¶ 2314 2316 W4303182909.pdf 2 28 bibliography 0.99760634 "Koch, S. C., Acton, D., and Goulding, M. (2018). Spinal circuits for touch, pain, and itch. Annu. Rev. Physiol . 80, 189–217. doi:10.1146/annurev-physiol-022516-034303" 2316 2488 W4303182909.pdf 2 29 separator 0.9780103 ¶ 2488 2490 W4303182909.pdf 2 30 bibliography 0.99782896 "Malfliet,A.,Coppieters,I.,VanWilgen,P.,Kregel,J.,DePauw,R. ,andDolphens, M., et al. (2017). Brain changes associated with cognitive an d emotional factorsin chronic pain: a systematic review. Eur. J. Pain 21, 769–786. doi: 10.1002/ejp. 1003" 2490 2734 W4303182909.pdf 2 31 separator 0.981843 ¶ 2734 2736 W4303182909.pdf 2 32 bibliography 0.9981067 "Mihailescu-Marin,M.M.,Mosoiu,D.V.,Burtea,V.,Sechel,G., Rogozea,L.M., andCiurescu,D.(2020).CommonpathwaysforpainandDepressio n-Implications forpractice. Am.J.Ther .27,e468–e476.doi:10.1097/MJT.0000000000001235" 2736 2949 W4303182909.pdf 2 33 separator 0.9772102 ¶ 2949 2951 W4303182909.pdf 2 34 bibliography 0.9979094 "Najafi, P., Dufor, O., Ben, S. D., Misery, L., and Carre, J. L. ( 2021). Itch processing in the brain. J. Eur. Acad. Dermatol. Venereol . 35, 1058–1066. doi:10.1111/jdv.17029" 2951 3129 W4303182909.pdf 2 35 separator 0.97500503 ¶ 3129 3131 W4303182909.pdf 2 36 bibliography 0.99801445 "Roberts,C.A.,Giesbrecht,T.,Stancak,A.,Fallon,N.,Thomas ,A.,andKirkham, T. C. (2019). Where is itch represented in the brain, and how do es it differ from pain?Anactivationlikelihoodestimationmeta-analysisofexpe rimentally-induced itch.J.Invest.Dermatol .139,2245–2248.doi:10.1016/j.jid.2019.04.007" 3131 3434 W4303182909.pdf 2 37 separator 0.9852363 ¶ 3434 3436 W4303182909.pdf 2 38 paratext 0.9262753 Frontiersin MolecularNeuroscience /zero.tnum/three.tnum frontiersin.org 3436 3508 W4303182909.pdf 2 0 paratext 0.9869499 Page 3/17 0 9 W3155187697.pdf 2 1 text 0.9986524 "Stimulation with ChemS157 led to rapid recruitment of arrestin3 to the receptor, reaching its maximum within two minutes as monitored by a bioluminescence resonance energy transfer (BRET) assay (Fig. 2a). Fluorescence microscopy showed that GPR1 recruits mCherry-labeled arrestin3 to the membrane upon stimulation with 1 μM ChemS157. However, GPR1 internalizes without arrestin3, leaving Arr3-mCherry at the membrane (Fig. 2b)." 9 440 W3155187697.pdf 2 2 separator 0.98791206 ¶ 440 442 W3155187697.pdf 2 3 text 0.9985714 To further characterize the activation of GPR1 by chemerin, we tested the effect of truncations of the ligand on arrestin3-recruitment in a BRET assay. 442 594 W3155187697.pdf 2 4 separator 0.97438586 ¶ 594 596 W3155187697.pdf 2 5 text 0.9995305 "Recombinantly expressed ChemS157 displayed a low nanomolar activity (EC50 = 2.1 nM). The same activity was observed for recombinantly expressed ChemF156 (EC50 = 2.6 nM). Next, we synthesized two peptides derived from the C-termini of ChemS157 and ChemF156, Chem139-157 and Chem139-156. These peptides displayed the same activities as the full-length proteins with EC50 values of 3.1 nM and 2.9 nM, respectively. Further truncating the peptide to yield Chem149-157 (chemerin-9) and Chem149-156 had no negative impact on activity. However, further N-terminal truncations resulted in a loss of activity: Chem150- 157 was tenfold less active than the full-length protein, while Chem151-157 was completely devoid of activity at concentrations up to 1 μM. Similarly, removal of the C-terminal Phe156 resulted in a complete loss of activity; Chem149-155 (chemerin-7) did not reach full receptor activation at concentrations of up to 1 μM." 596 1538 W3155187697.pdf 2 6 separator 0.9656224 ¶ 1538 1540 W3155187697.pdf 2 7 text 0.9948268 "Two scrambled chemerin-9 peptides (scrC9 and scr2C9) failed to induce arrestin3-recruitment at concentrations of up to 10 μM. Table 1 displays an overview of all EC50 values." 1540 1717 W3155187697.pdf 2 8 separator 0.9948826 ¶ 1717 1719 W3155187697.pdf 2 9 caption 0.93864346 "Table 1: Activity of chemerin and derived proteins and peptides at the GPR1 in a BRET-based arrestin3-recruitment assay. Nonlinear regression was performed in GraphPad Prism 5, with mean values from at least two independent experiments performed in quadruplicates." 1719 1986 W3155187697.pdf 2 10 separator 0.9775424 ¶ 1986 1988 W3155187697.pdf 2 11 table 0.9945993 "Peptide Sequence EC50 / nM pEC50 ± SEM Emax ChemS157 21-157 2.1 8.68 ± 0.14 103 ± 8 ChemF156 21-156 2.6 8.57 ± 0.16 106 ± 9 Chem139-157 QRAGEDPHSFYFPGQFAFS 3.1 8.51 ± 0.14 94 ± 7 Chem139-156 QRAGEDPHSFYFPGQFAF 2.9 8.53 ± 0.17 99 ± 9 Chem149-157 (=chemerin-9)YFPGQFAFS 1.9 8.76 ± 0.09 101 ± 4 Chem150-157 FPGQFAFS 22 7.65 ± 0.16 87 ± 8 Chem151-157 PGQFAFS >1,000 <6 n.d. Chem149-156 YFPGQFAF_ 4.0 8.40 ± 0.34 110 ± 16 Chem149-155 (chemerin-7)YFPGQFA__ >1,000 <6 n.d. scrC9 GYFPFQASF >1,000 <6 n.d. scr2C9 QFYSFFPAG >1,000 <6 n.d. [L8] chemerin-9YFPGQFALS 1.4 8.86 ±0.19 125 ± 12" 1988 2590 W3155187697.pdf 2 12 separator 0.939412 ¶ 2590 2592 W3155187697.pdf 2 13 table 0.94603014 3.2 Identi 2592 2609 W3155187697.pdf 2 0 text 0.995576 "increase in Cdc25A protein in A β-treated cortical neuron cultures. Thus, our study favours a mechanism in which A β elevates Cdc25A expression via FoxO-miR21 signalling andour data clearly identify Cdc25A as a required player in Aβ-induced neuron death." 0 260 W2597420489.pdf 1 1 separator 0.97691447 ¶ 260 262 W2597420489.pdf 1 2 text 0.99945915 "In summary, our study reveals that Cdc25A is elevated, activated and has an essential role in neuronal cell death evoked by apoptotic stimuli relevant to normal development and to AD. Because Cdc25A is an inhibitable enzyme, our studyidentifies Cdc25A as a potential target to block pathologicneuron degeneration and death in AD and other pathologies in which the neuronal apoptotic cell cycle pathway is activated. In support of this idea, a selective Cdc25A inhibitor has beenshown to be effective in several non-neuronal experimental disease models and without reported toxicity." 262 857 W2597420489.pdf 1 3 separator 0.9905869 ¶ 857 859 W2597420489.pdf 1 4 paratext 0.9250665 14 859 862 W2597420489.pdf 1 5 separator 0.99232185 ¶ 862 864 W2597420489.pdf 1 6 title 0.9680766 Conflict of Interest 864 885 W2597420489.pdf 1 7 text 0.7683231 The authors declare no conflict of interest. 885 929 W2597420489.pdf 1 8 separator 0.9937217 ¶ 929 931 W2597420489.pdf 1 9 bibliography 0.98757344 "1. Greene LA et al. Biochim Biophys Acta 2007; 1772 : 392 –401. 2. Biswas SC et al. J Neurosci 2005; 25: 8349 –8358. 3. Biswas SC et al. J Biol Chem 2007; 282: 29368 –29374.4. Biswas SC et al. J Neurosci 2007; 27: 893 –900." 931 1159 W2597420489.pdf 1 10 separator 0.841882 ¶ 1159 1161 W2597420489.pdf 1 11 bibliography 0.9720746 "5. Aressy B et al. Anticancer Agents Med Chem 2008; 8: 818 –824. 6. Chatterjee N et al. Cell Death Discov 2016; 2: 16083. 7. Lee HK et al. Mol Biol Cell 2009; 20: 1533 –1544. 8. Sanphui P et al. Cell Death Dis 2013; 4: e625. 9. Zareen N et al. Cell Death Differ 2013; 20: 1719 –1730. " 1161 1454 W2597420489.pdf 1 12 separator 0.5318565 ¶ 1454 1455 W2597420489.pdf 1 13 bibliography 0.98403174 "10. Brunet A et al. Cell 1999; 96: 857 –8681999. 11. Zhang Y et al. J Neurosci 2006; 26: 8819 –8828. 12. Ding XL et al. Am J Pathol 2000; 157: 1983 –1990. 13. Kruman II et al. Neuron 2004; 41: 549 –561. 14. Kar S et al. Mol Cancer Ther 2006; 5: 1511 –1519." 1455 1720 W2597420489.pdf 1 14 separator 0.9811243 ¶ 1720 1722 W2597420489.pdf 1 15 paratext 0.9093111 "Cell Death and Disease is an open-access journal published by Nature Publishing Group . This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article areincluded in the article ’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission fromthe license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/" 1722 2305 W2597420489.pdf 1 16 separator 0.7820786 ¶ 2305 2307 W2597420489.pdf 1 17 paratext 0.9354218 rThe Author(s) 2017 2307 2327 W2597420489.pdf 1 18 separator 0.9868785 ¶ 2327 2329 W2597420489.pdf 1 19 table 0.98694307 "E2FHealthy Condition FoxO3aP FoxO3aP Phosphorylated (Cytoplasmic)FoxO3a FoxO3aPFoxO3aFoxO3a Dephosphorylated (Nuclear) miR21 Transcribed Cdc25ALow levels Low activity Cdk4PPPhosphorylated Inactive RBRepression of Apoptotic genesmiR21Repressed Cdc25AInduced Active Cdk4 Dephosphorylated Active E2FRB BimP Caspase activationAβ AktPAkt Myb MybE2F-Rb complex dissociates, apoptotic genes de- repressed" 2329 2787 W2597420489.pdf 1 20 separator 0.97464806 ¶ 2787 2789 W2597420489.pdf 1 21 caption 0.9449101 "Figure 1 Scheme depicting a molecular pathway by which Cdc25A is induced/activated and promotes neuron death in disease and development. In healthy cells, Ak t phosphorylates FoxO transcription factors and retains them in the cytosol. miR-21, a microRNA that suppresses Cdc25A expression and that is negativ ely regulated by FoxO3a, remains elevated in the nucleus to block the apoptotic cell cycle pathway. A βtreatment and NGF deprivation inhibit neuronal Akt signalling. When Akt signal" 2789 3283 W2597420489.pdf 1 22 text 0.580697 ling 3283 3287 W2597420489.pdf 1 23 caption 0.5188973 is suppress 3287 3299 W2597420489.pdf 1 24 text 0.5441473 ed 3299 3301 W2597420489.pdf 1 25 caption 0.6823198 , 3301 3302 W2597420489.pdf 1 26 text 0.42462724 3302 3303 W2597420489.pdf 1 27 caption 0.41218567 ¶ 3303 3304 W2597420489.pdf 1 28 text 0.76375484 FoxO proteins are activated and translocate to the nucleus. FoxO3a downregulates miR-21 and thereby upregulates Cdc25A. Elevated 3304 3433 W2597420489.pdf 1 29 caption 0.51440233 and 3433 3437 W2597420489.pdf 1 30 text 0.5355264 activated Cdc 3437 3451 W2597420489.pdf 1 31 caption 0.5517206 25 3451 3454 W2597420489.pdf 1 32 text 0.5245799 A 3454 3455 W2597420489.pdf 1 33 caption 0.55521226 leads to 3455 3464 W2597420489.pdf 1 34 text 0.53234583 Cdk 3464 3468 W2597420489.pdf 1 35 caption 0.36663896 4 3468 3470 W2597420489.pdf 1 36 text 0.52570367 ¶ activation and subsequent Rb phosphorylation 3470 3516 W2597420489.pdf 1 37 caption 0.639529 , 3516 3517 W2597420489.pdf 1 38 text 0.47539067 expression 3517 3528 W2597420489.pdf 1 39 caption 0.52941364 of E 3528 3533 W2597420489.pdf 1 40 text 0.44221723 2F 3533 3535 W2597420489.pdf 1 41 caption 0.5068336 -responsive genes such as 3535 3560 W2597420489.pdf 1 42 text 0.48632804 B 3560 3562 W2597420489.pdf 1 43 caption 0.46130696 - 3562 3563 W2597420489.pdf 1 44 text 0.5662008 and C-myb 3563 3573 W2597420489.pdf 1 45 caption 0.6318673 , in 3573 3577 W2597420489.pdf 1 46 text 0.5243818 duction of 3577 3587 W2597420489.pdf 1 47 caption 0.53331447 Bim, caspase activation and neu ron death 3587 3629 W2597420489.pdf 1 48 title 0.91905916 News and Commentary 3629 3648 W2597420489.pdf 1 49 separator 0.72352237 ¶ 3648 3650 W2597420489.pdf 1 50 paratext 0.68745196 2 3650 3652 W2597420489.pdf 1 51 separator 0.9730598 ¶ 3652 3654 W2597420489.pdf 1 52 title 0.92991483 Cell Death and Disease 3654 3677 W2597420489.pdf 1 0 paratext 0.9865982 Rev Assoc Med Bras 2006; 52(6): 441-6 446ROCHA ATC ET AL. 0 57 W2070526140.pdf 5 1 separator 0.9944694 ¶ 57 59 W2070526140.pdf 5 2 text 0.995276 "apenas a minoria dos pacientes clínicos hospitalizados e candidatos a profilaxia recebem prescrição adequada. Um programa educacional, emnível nacional, com recomendações sobre profilaxia a fim de aproximara evidência da prática clínica é extremamente desejável." 59 324 W2070526140.pdf 5 3 separator 0.8822036 ¶ 324 326 W2070526140.pdf 5 4 text 0.99377745 "Conflito de interesse: A primeira autora (ATCR) é consultora da Sanofi-Aventis." 326 408 W2070526140.pdf 5 5 separator 0.9940443 ¶ 408 410 W2070526140.pdf 5 6 title 0.98928094 SUMMARY 410 418 W2070526140.pdf 5 7 separator 0.89323306 ¶ 418 420 W2070526140.pdf 5 8 title 0.9893155 "INADEQUACY OF T HROMBOPROPHYLAXIS IN H OSPITALIZED MEDICAL PATIENTS" 420 493 W2070526140.pdf 5 9 separator 0.99160683 ¶ 493 495 W2070526140.pdf 5 10 text 0.98891985 "BACKGROUND . The risk of venous thromboembolism (VTE) is high in hospitalized patients, however it can be reduced by adequate prophylaxis." 495 636 W2070526140.pdf 5 11 separator 0.9866488 ¶ 636 638 W2070526140.pdf 5 12 text 0.68844086 OBJEC 638 644 W2070526140.pdf 5 13 title 0.54350394 TIVE 644 648 W2070526140.pdf 5 14 text 0.99144644 ". To evaluate the adequacy of VTE prophylaxis in hospitalized medical patients." 648 730 W2070526140.pdf 5 15 separator 0.98582256 ¶ 730 732 W2070526140.pdf 5 16 text 0.972112 "METHODS . A cross-sectional study was performed in hospitalized patients with acute medical illnesses in 4 hospitals of Salvador." 732 864 W2070526140.pdf 5 17 separator 0.9879468 ¶ 864 866 W2070526140.pdf 5 18 text 0.5109702 866 867 W2070526140.pdf 5 19 title 0.6048653 RESULTS 867 874 W2070526140.pdf 5 20 text 0.99902564 ". We evaluated 226 consecutive patients: 15.5% in medical ICU, 79% ≥ 40 years of age and 48% male. The majority (97%) had a least 1 risk factor (RF) for VTE, 79% had reduced mobility and 62% were diagnosed as having a RF at admission. Of the 208 prophylaxis candidates, 54% received some form of prophylaxis: unfractionated heparin (UFH) in 44%, low molecular weight heparin (LMWH) in 56% and mechanical methods in 2 patients. The utilization rate was similar in private and public hospitals. (51% vs. 49%), but LMWH was more common in private hospitals, without a residence program (97%), and UFH in the public ones (86%). LMWH was more frequently used than UFH in patients ≥ 40 years of age, more often in Caucasian than in Black patients, and less frequently in those with contraindications for heparin. Of the 112 patients receiving prophylaxis, 63% received adequate dosages: LMWH in 95.2% and UFH in 20.4%. VTE prophylaxis was adequate in only 33.6% (70/208) of the patients." 874 1885 W2070526140.pdf 5 21 separator 0.9953041 ¶ 1885 1887 W2070526140.pdf 5 22 title 0.86137104 CONCLUSION 1887 1898 W2070526140.pdf 5 23 separator 0.8555172 1898 1899 W2070526140.pdf 5 24 text 0.97916514 . Risk Factors for VTE were frequent in medical patients. 1899 1956 W2070526140.pdf 5 25 separator 0.5319781 1956 1957 W2070526140.pdf 5 26 text 0.95872986 "¶ There was considerable variability of the VTE prophylaxis prescribed in private and public hospitals. LMWH was used more appropriately than UFH. However, only a minority of patients candidates for prophylaxis, received adequate dosages. [Rev Assoc Med Bras 2006; 52" 1957 2230 W2070526140.pdf 5 27 bibliography 0.6327995 (6): 441-6 2230 2240 W2070526140.pdf 5 28 text 0.5921961 ] 2240 2241 W2070526140.pdf 5 29 separator 0.9947859 ¶ 2241 2243 W2070526140.pdf 5 30 title 0.83450764 KEY WORDS 2243 2253 W2070526140.pdf 5 31 separator 0.6561827 2253 2254 W2070526140.pdf 5 32 title 0.4673637 : 2254 2255 W2070526140.pdf 5 33 bibliography 0.40643886 Th 2255 2258 W2070526140.pdf 5 34 title 0.42089403 romboembolism. Risk factors. Prevention and control 2258 2309 W2070526140.pdf 5 35 text 0.39268312 . 2309 2310 W2070526140.pdf 5 36 separator 0.3029509 2310 2311 W2070526140.pdf 5 37 text 0.4155649 ¶ Internal Medicine. Heparin. G 2311 2342 W2070526140.pdf 5 38 title 0.39935157 uidelines for 2342 2355 W2070526140.pdf 5 39 text 0.34630403 medical 2355 2363 W2070526140.pdf 5 40 title 0.36566475 practice 2363 2372 W2070526140.pdf 5 41 text 0.3753398 . 2372 2373 W2070526140.pdf 5 42 separator 0.9859851 ¶ 2373 2375 W2070526140.pdf 5 43 title 0.92466414 REFERÊNCIAS 2375 2387 W2070526140.pdf 5 44 separator 0.9887279 ¶ 2387 2389 W2070526140.pdf 5 45 bibliography 0.997973 "1. Kleber FX, Witt C, Vogel G, Koppenhagen K, Schomaker U, Flosbach CW. Randomized comparison of enoxaparin with unfractionated heparinfor the prevention of venous thromboembolism in medical patients withheart failure or severe respiratory disease. Am Heart J. 2003;145:614-21." 2389 2669 W2070526140.pdf 5 46 separator 0.92838997 ¶ 2669 2671 W2070526140.pdf 5 47 bibliography 0.99803025 "2. Kleber FX, Witt C, Flosbach CW. 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Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery. Annals of neurology, 33(6), 583 -590." 4649 4911 W2594539793.pdf 6 45 separator 0.944555 ¶ 4912 4914 W2594539793.pdf 6 46 bibliography 0.99794835 "49. Wallace, M. S., Wallace, A. M., Lee, J., &Dobke, M. K. (1996). Pain after breast surgery: a survey of 282 women. Pain, 66(2), 195 -205." 4914 5057 W2594539793.pdf 6 47 separator 0.96095234 ¶ 5058 5060 W2594539793.pdf 6 48 bibliography 0.9980674 "50. Wattier, J. M., Caïazzo, R., Andrieu, G., Kipnis, E., Pattou, F., &Lebuffe, G. (2016). Chronic post -thyroidectomy pain: Incidence, typology, and risk factors. Anaesthesia Critical Care & Pain Medicine , 35(3), 197 -201." 5060 5289 W2594539793.pdf 6 49 separator 0.95722085 ¶ 5290 5292 W2594539793.pdf 6 50 bibliography 0.998051 "51. Wildgaard, K., Ringsted, T. K., Hansen, H. J., Petersen, R. H., &Kehlet, H. (2016). Persistent postsurgical pain after video‐assisted thoracic surgery –an observational study. ActaAnaesthesiologicaScandinavica" 5292 5510 W2594539793.pdf 6 51 separator 0.98586035 ¶ 5512 5514 W2594539793.pdf 6 0 paratext 0.97342044 RESEARCH FOCUS | VOLUME 2 | ISSUE 3 | 202 3 0 51 W4361867263.pdf 3 1 separator 0.5297128 ¶ 53 55 W4361867263.pdf 3 2 paratext 0.8982567 ISSN: 2181 -3833 Research 55 90 W4361867263.pdf 3 3 table 0.68343455 Bip (14) | Google Scholar | SJIF ( 5.708 ) | UIF (8.3) 90 144 W4361867263.pdf 3 4 separator 0.7747642 "¶ " 146 155 W4361867263.pdf 3 5 paratext 0.9307655 ¶ Research Focus, Uzbekistan refocus.uz 155 198 W4361867263.pdf 3 6 separator 0.9917172 ¶ 200 202 W4361867263.pdf 3 7 bibliography 0.9978929 "2. Abdullaev S., Akhmedov A. T. A., Djalolov D. Problems of surgical tactics for the treatment of diabetic foot syndrome //International Journal of Advanced Science and Technology. – 2020. – Т. 29. – No. 5. – С. 1836 -1838." 203 433 W4361867263.pdf 3 8 separator 0.9543114 ¶ 435 437 W4361867263.pdf 3 9 bibliography 0.9976902 "3. Abdullaev S. et al. 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РЕЗУЛ ЬТАТЫ ЛЕЧЕНИЯ БОЛЬНЫХ ОСТРЫМ ГАНГРЕНОЗНО НЕКРОТИЧЕСКИМ ПАРАПРОКТИТОМ //Research Focus. – 2023. – Т. 2. – No. 1. – С. 483 -486." 2085 2273 W4361867263.pdf 3 28 separator 0.95976686 ¶ 2274 2276 W4361867263.pdf 3 29 bibliography 0.9978976 "13. Abakumov M. M. et al. Diaphragmatic ruptures in combined injuries to the chest and abdomen //Vestnik Khirurgii Imeni II Grekova. – 1991. – Т. 146. – No. 5. – С. 64 -68." 2276 2451 W4361867263.pdf 3 30 separator 0.963357 ¶ 2452 2454 W4361867263.pdf 3 31 bibliography 0.9978312 "14. I.M. Rustamov, J .A. Karabayev . MODERN APPROACH TO THE TREATMENT OF PATIENTS WITH ACUTE GANGRENOUS -NECROTIC PARAPROCTITIS //Research Focus. – 2023. – Т. 2. – No. 1. – С. 469-472." 2454 2645 W4361867263.pdf 3 32 separator 0.95584047 ¶ 2646 2648 W4361867263.pdf 3 33 bibliography 0.99781996 "15. Murodulla R. et al. A RARE CASE OF KERATOAKONTOMA //Thematics Journal of Education. – 2022. – Т. 7. – No. 3." 2648 2764 W4361867263.pdf 3 34 separator 0.92595863 ¶ 2765 2767 W4361867263.pdf 3 35 bibliography 0.9977235 "16. РУСТАМОВ М. И. и др. Современная тактика лечения острого парапроктита //Журнал биомедицины и практики. – 2022. – Т. 7. – No. 2." 2767 2901 W4361867263.pdf 3 36 separator 0.936517 ¶ 2903 2905 W4361867263.pdf 3 37 bibliography 0.9977236 "17. Ismailov S. I. et al. Predicto rs of postoperative complications in patients with ventral hernia //Khirurgiia. – 2022. – No. 1. – С. 56 -60." 2905 3052 W4361867263.pdf 3 38 separator 0.96809745 ¶ 3053 3055 W4361867263.pdf 3 39 bibliography 0.99770373 "18. Dusiyarov M.M., Eshonxodjaev J.D., Xujabaev S.T., Sherkulov K.U., & Rustamov I.M. (2021). Estimation of the efficiency of antisseal coating on the m odel of lung wound in experiment. Central Asian Journal of Medical and Natural Science , 1(4), 1 -6." 3055 3316 W4361867263.pdf 3 40 separator 0.97800434 ¶ 3317 3319 W4361867263.pdf 3 41 bibliography 0.7018281 https://doi.org 3319 3335 W4361867263.pdf 3 42 paratext 0.6276482 /10.47494/cajmns.v1i4.57 3335 3360 W4361867263.pdf 3 43 bibliography 0.5621795 . 3360 3361 W4361867263.pdf 3 0 separator 0.58378375 1 2 W4391536688.pdf 3 1 paratext 0.8975272 ¶ Hal. 142 1 11 W4391536688.pdf 3 2 separator 0.99285126 ¶ 13 15 W4391536688.pdf 3 3 text 0.9976668 "dimaksudkan agar auditor dapat memberikan kepercayaan kepada klien terhadap aktivitasnya (IAI2001). Selain itu (IAI: 2001), auditor pada prinsipnya harus menggunakan pertimbangan lebih dari satu pertimbangan rasional berdasarkan pemahamannya terhadap penerapan etika y ang berlaku dan mengambil keputusan yang adil, oleh karena itu diperlukan pelayanan yang independen dan profesional menilai secara obyektif kebenaran dan alasan laporan keuangan yang disajikan oleh manajemen Kebutuhan akan perilaku profesional dalam profe si apapun adalah kebutuhan akan kepercayaan masyarakat kualitas layanan yang diberikan oleh profesi, terlepas dari layanan mana yang diberikan secara terpisah. (Hildayani, 2008)" 16 746 W4391536688.pdf 3 4 separator 0.98629916 ¶ 748 750 W4391536688.pdf 3 5 text 0.9985744 "Di Indonesia, fenomena lemahnya kualitas audit termanifestasi saat Menteri Keuangan Sri Mulyani Indrawati membekukan izin akuntan publik Kasner Sirumapea selama 12 bulan dan memberikan sanksi administratif pada KAP Tanubrata, Sutanto, Fahmi, Bambang & Rekan yang mengaud it laporan keuangan PT Garuda Indonesia Tbk per 31 Desember 2018. Auditor tersebut belum sepenuhnya mematuhi Standar Audit (SA) dan kurang menerapkan sistem pengendalian mutu optimal terkait konsultasi dengan pihak eksternal, yang menyebabkan kurangnya sik ap independensi, integritas, dan kompetensi, merugikan kualitas audit. (Muslim et al., 2020)" 751 1393 W4391536688.pdf 3 6 separator 0.9872095 ¶ 1395 1397 W4391536688.pdf 3 7 text 0.9983935 "Hal yang perlu diperhatikan adalah etika auditor yang harus tunduk pada ketentuan yang ditetapkan oleh Institut Akuntan Publik Indonesia (IAPI). Kode etik IAPI menetapkan lima prinsip dasar yang harus diikuti oleh seorang au ditor. Ini melibatkan integritas, di mana auditor diharapkan bersikap jujur dan tidak berbelit -belit; objektivitas, dengan menekankan ketidakpemilihan antara profesionalitas dan bisnis; kompetensi, yang menuntut tingkat profesionalisme untuk layanan yang k ompeten; kehati -hatian profesional, yang mengamanatkan penerapan standar dengan sungguh - sungguh; kerahasiaan, di mana auditor diwajibkan menjaga informasi rahasia; dan perilaku profesional, yang mengharuskan auditor mematuhi aturan hukum dan menjaga perila ku yang mendukung profesionalitas. (Suhariadi Dwi, 2022)" 1398 2225 W4391536688.pdf 3 8 separator 0.9957601 ¶ ¶ 2227 2233 W4391536688.pdf 3 9 title 0.99089605 KAJIAN LITERATUR 2233 2250 W4391536688.pdf 3 10 separator 0.9922651 ¶ 2252 2254 W4391536688.pdf 3 11 title 0.7181511 Etika profes i 2254 2269 W4391536688.pdf 3 12 text 0.6386272 seorang akuntan 2269 2285 W4391536688.pdf 3 13 separator 0.9058347 ¶ 2288 2290 W4391536688.pdf 3 14 text 0.99944896 "Profesi merupakan suatu pekerjaan yang memerlukan pengalaman, pendidikan dan keterampilan yang mendalam me miliki pengetahuan khusus. Suat u profesi dapat disebut profesi apabila mempunyai sertifikat dan lisensi yang bisa menjadi pertimbangan dalam pekerjaan Anda, yang membutuhkan proses jangka panjan g untuk waktu yang lama bisa disebut profesi. Seseorang yang mempunyai pekerjaan tertentu, misalnya suatu pro fesi akuntan disebut profesional (Widaningsih, 2017). Namun, etika berasal dari kata Yunani “Ethos” atau (jamak -ta etha), yaitu cara yang etis. Etika erat kaitannya dengan nilai -nilai dan budaya adat istiadat tertentu yang dianu t diwariskan ." 2290 2977 W4391536688.pdf 3 15 separator 0.846123 ¶ 2978 2980 W4391536688.pdf 3 16 text 0.99915195 "Etika merupak an ilmu yang pada hakikatnya mempunyai nilai baikdan buruk suatu perbuatan seseorang dan mempunyai kewajiban moral (moralitas) yang diyakini seseorang kelompok, diri sendiri atau masyarakat (Kusumaningtyas dan Solikah, 2016)." 2980 3227 W4391536688.pdf 3 17 separator 0.954619 ¶ 3229 3231 W4391536688.pdf 3 18 text 0.99909097 "Singkatnya, dapat disimpulkan bahwa etika profesional seharusnya menjadi aturan bersama menghubungkan secara normal antara hubungan antarmanusia dan mempunyai nilai -nilai normatif dalam bentuk aturan etika profesi. Kode etik ini dapat mengatur hubungan antar pelanggan auditor, rekan profesional dan auditor, masyarakat dan auditor (Rinaldy et al. 2020). Kode etik diatur Dalam SPAP (Standar Profesi Akuntan Publik) yang bertujuan untuk mengatur etika wajib memenuhi kewajibannya kepada auditor untuk melaksanakan pekerjaannya secara efe ktif dengan keterampilan profesional. (Susilawati et al., 2022)" 3231 3860 W4391536688.pdf 3 19 separator 0.99551344 ¶ 3862 3864 W4391536688.pdf 3 20 text 0.9779631 Menurut Soekrisna Agoes (20 16), jabatan adalah konsep kerj a hal-hal mulia yang 3864 3945 W4391536688.pdf 3 0 paratext 0.9800055 "533 https://yashil-iqtisodiyot-taraqqiyot.uz" 0 46 W4392254516.pdf 7 1 separator 0.95971036 ¶ 46 48 W4392254516.pdf 7 2 title 0.7992327 "MUNDARIJA СОДЕРЖАНИЕ CONTENTSYASHIL IQTISODIYOT VA TARAQQIYOT 2023-yil, dekabr . Maxsus son.Modern Trend s in the Development of Tourism and the Experience of Foreign Countries in the Application of Smart Innovations in Personnel Training " 48 291 W4392254516.pdf 7 3 table 0.40704504 ................................................ 291 339 W4392254516.pdf 7 4 title 0.32746074 ...... 339 345 W4392254516.pdf 7 5 table 0.4681261 62 345 348 W4392254516.pdf 7 6 separator 0.98791337 ¶ 348 350 W4392254516.pdf 7 7 contact 0.52697843 Iskandarova Nargiza 350 370 W4392254516.pdf 7 8 bibliography 0.81829375 "Mashrabjonovna The Main Role of Smart – Tourism in Modern XXI Century Uzbekistan as an Example ................................................... 65" 370 523 W4392254516.pdf 7 9 separator 0.96475995 ¶ 523 525 W4392254516.pdf 7 10 bibliography 0.53292644 Narzullayeva 525 538 W4392254516.pdf 7 11 contact 0.55838937 Fariza Akmalevna 538 555 W4392254516.pdf 7 12 bibliography 0.53696877 , 555 556 W4392254516.pdf 7 13 contact 0.52795845 Saydaliyev 556 567 W4392254516.pdf 7 14 bibliography 0.5096141 a 567 568 W4392254516.pdf 7 15 contact 0.48109704 Fer 568 572 W4392254516.pdf 7 16 bibliography 0.4795425 uza Bakh 572 580 W4392254516.pdf 7 17 contact 0.5267261 tiyo 580 584 W4392254516.pdf 7 18 bibliography 0.852365 "rovna How Does Smart Tourism Support Sustainable Tourism Development: the Case of Uzbekistan ................................ 67" 584 715 W4392254516.pdf 7 19 separator 0.9469907 ¶ 715 717 W4392254516.pdf 7 20 contact 0.6212509 Khusniddin Egamnazar 717 738 W4392254516.pdf 7 21 bibliography 0.72523 "ov Appearances, Classification and Application of Smart Tourism ................................................................................................. 70" 738 905 W4392254516.pdf 7 22 separator 0.973101 ¶ 905 907 W4392254516.pdf 7 23 contact 0.5818417 Akhmadjanova Mukhtasarkhan Anvar qizi 907 945 W4392254516.pdf 7 24 bibliography 0.4703137 , 945 946 W4392254516.pdf 7 25 contact 0.5203774 Shari 946 952 W4392254516.pdf 7 26 bibliography 0.47954968 f 952 953 W4392254516.pdf 7 27 contact 0.52851444 boyeva Fazilatxon Odilbek qizi 953 983 W4392254516.pdf 7 28 bibliography 0.53184897 , 983 984 W4392254516.pdf 7 29 contact 0.5479746 Dadamir 984 992 W4392254516.pdf 7 30 bibliography 0.5327481 zayev 992 997 W4392254516.pdf 7 31 contact 0.5033449 Sarvarbek Ulug 997 1012 W4392254516.pdf 7 32 bibliography 0.5105429 ʻ 1012 1013 W4392254516.pdf 7 33 contact 0.49698174 bek o 1013 1018 W4392254516.pdf 7 34 bibliography 0.6040762 "ʻgʻli Фарғона водийсининг қишлоқ аҳоли пунктларида агротуризмни ривожлантиришнинг стратегик режасини ва смарт-технология концепциясини ишлаб чиқиш бўйича услубий ёндашувлар ........................ 74" 1018 1224 W4392254516.pdf 7 35 separator 0.95760256 ¶ 1224 1226 W4392254516.pdf 7 36 contact 0.6072434 Жумабаева Дилафруз Тожидиновна 1226 1257 W4392254516.pdf 7 37 bibliography 0.6946318 ¶ Butun jahon Smart-turizmi bozorining rivojlanish xususiyatlari .............................................................................................. 78 1257 1421 W4392254516.pdf 7 38 separator 0.932703 ¶ 1421 1423 W4392254516.pdf 7 39 contact 0.6367911 Ravshanov To‘yli Gulmurodovich 1423 1454 W4392254516.pdf 7 40 bibliography 0.7122666 "¶ Основные тенденции развития смарт туризма в условиях цифровой экономики в Республике Узбекистан ........................................................................................................................ 81" 1454 1679 W4392254516.pdf 7 41 separator 0.95443 ¶ 1679 1681 W4392254516.pdf 7 42 contact 0.50453067 Салиева Екатерин 1681 1698 W4392254516.pdf 7 43 bibliography 0.77512443 "а Сергеевна Развитие Смарт-туризма в Узбекистане на основе современных принципов и использования зарубежного опыта ..................................................................................................................... 84" 1698 1938 W4392254516.pdf 7 44 separator 0.96173406 ¶ 1938 1940 W4392254516.pdf 7 45 bibliography 0.5033584 Ахмеджанова 1940 1952 W4392254516.pdf 7 46 contact 0.47228044 Ирада Усмановна 1952 1968 W4392254516.pdf 7 47 bibliography 0.4736301 , Халилова Нодира Абду 1968 1990 W4392254516.pdf 7 48 contact 0.4728175 хамид 1990 1995 W4392254516.pdf 7 49 bibliography 0.75318664 "қизи Будущая роль Смарт-туризма на мировом туристическом рынке .................................................................................. 88" 1995 2147 W4392254516.pdf 7 50 separator 0.94038737 ¶ 2147 2149 W4392254516.pdf 7 51 bibliography 0.41551057 2149 2150 W4392254516.pdf 7 52 contact 0.4551911 Уралова Матлюба Ахрор 2150 2171 W4392254516.pdf 7 53 bibliography 0.6340782 "овна Проблемы и перспективы развития Smart-туризма в Узбекистане" 2171 2237 W4392254516.pdf 7 54 table 0.49766204 ............................................................................... 95 2238 2321 W4392254516.pdf 7 55 separator 0.9443699 ¶ 2321 2323 W4392254516.pdf 7 56 contact 0.5396968 Очилова Хилола Фармоновна, Раимова Севара Ойбеков 2323 2373 W4392254516.pdf 7 57 bibliography 0.57961273 "на Перспективы развития Смарт-туризма в Республике Узбекистан" 2373 2436 W4392254516.pdf 7 58 table 0.4761498 2436 2437 W4392254516.pdf 7 59 bibliography 0.5419071 ¶ на основе современных технологий 2437 2471 W4392254516.pdf 7 60 table 0.4792098 2471 2472 W4392254516.pdf 7 61 bibliography 0.56142235 и использования зарубежного опыта 2472 2505 W4392254516.pdf 7 62 table 0.5278866 .............................................................. 102 2506 2573 W4392254516.pdf 7 63 separator 0.95138323 ¶ 2573 2575 W4392254516.pdf 7 64 contact 0.5687568 Рустамов Аброр Равшан угли 2575 2602 W4392254516.pdf 7 65 bibliography 0.69986415 ¶ Перспективы развития зелёного cмарт туризма в Республики Узбекистан ............................................................. 2602 2735 W4392254516.pdf 7 66 table 0.43895122 106 2735 2739 W4392254516.pdf 7 67 separator 0.8502446 ¶ 2739 2741 W4392254516.pdf 7 68 contact 0.51454365 Расулова Нигора Юсуповна 2741 2766 W4392254516.pdf 7 69 bibliography 0.6709283 ¶ Перспективы развития смарт туризма в Узбекистане на основе современных принципов ........................... 2766 2878 W4392254516.pdf 7 70 table 0.44344422 110 2878 2882 W4392254516.pdf 7 71 separator 0.85397875 ¶ 2882 2884 W4392254516.pdf 7 72 contact 0.45030034 Рахимова Дилфуза Мирзакасим 2884 2912 W4392254516.pdf 7 73 bibliography 0.6255614 "овна Перспективные направления развития смарт туризма в Узбекистане" 2912 2981 W4392254516.pdf 7 74 table 0.50251293 ....................................................... 2982 3038 W4392254516.pdf 7 75 bibliography 0.47029954 ................ 3038 3054 W4392254516.pdf 7 76 table 0.5554894 113 3054 3058 W4392254516.pdf 7 77 separator 0.9202893 ¶ 3058 3060 W4392254516.pdf 7 78 contact 0.6128712 Гузал Шеровна Хонкелдиева 3060 3086 W4392254516.pdf 7 79 bibliography 0.78681314 "¶ Развитие культурного Смарт-туризма в Узбекистане, с использованием опыта зарубежной компании «POLYMEDIA» ....................................................................................... 116" 3086 3288 W4392254516.pdf 7 80 separator 0.9415611 ¶ 3288 3290 W4392254516.pdf 7 81 contact 0.57523465 Караваева Алёна Виктор 3290 3313 W4392254516.pdf 7 82 bibliography 0.74884635 "овна Turistik xizmatlar bozorini shakllantirishning rekreatsion dinamikasi ................................................................................. 118" 3313 3476 W4392254516.pdf 7 83 separator 0.9674916 ¶ 3476 3478 W4392254516.pdf 7 84 contact 0.8192243 Bahrieva Zarina Nasimovna 3478 3504 W4392254516.pdf 7 85 separator 0.5142101 3504 3505 W4392254516.pdf 7 86 contact 0.44105673 ¶ 3505 3506 W4392254516.pdf 7 87 title 0.7107776 2-ШУЪБА 3506 3514 W4392254516.pdf 7 88 separator 0.7882696 ¶ 3514 3516 W4392254516.pdf 7 89 title 0.82432866 SMART-ТУРИЗМНИ ТАШКИЛ ЭТИШНИНГ АСОСИЙ ХУСУСИЯТЛАРИ 3516 3567 W4392254516.pdf 7 90 separator 0.5361768 ¶ 3567 3569 W4392254516.pdf 7 91 table 0.520402 Main Features 3569 3583 W4392254516.pdf 7 92 bibliography 0.49351877 of Smart 3583 3592 W4392254516.pdf 7 93 table 0.7312783 Tourism Organization .................................................................................................................................. 121 3592 3749 W4392254516.pdf 7 94 separator 0.89758915 ¶ 3749 3751 W4392254516.pdf 7 95 contact 0.61477435 Narzullaeva Umidakhon 3751 3773 W4392254516.pdf 7 96 bibliography 0.705824 ¶ The Role Smart-City Infrastructure in the Tourism and Architecture ..................................................................................... 124 3773 3933 W4392254516.pdf 7 97 separator 0.9428204 ¶ 3933 3935 W4392254516.pdf 7 98 contact 0.54119635 Mukhlisa Akromova Saydimukhtor 3935 3966 W4392254516.pdf 7 99 bibliography 0.7057619 "qizi The Main Components of the Development of “Smart” Tourism in the Region .................................................................. 130" 3966 4117 W4392254516.pdf 7 100 separator 0.98755443 ¶ 4117 4119 W4392254516.pdf 7 101 contact 0.74424064 Agzamova Nargiza Gapurovna 4119 4146 W4392254516.pdf 7 0 title 0.7855885 Costantini Oxidative Stress and Reproduction 0 44 W2324622141.pdf 2 1 separator 0.9934778 ¶ 44 46 W2324622141.pdf 2 2 bibliography 0.99665207 "Novikov, E., Kondratyuk, E., Petrovski, D., Titova, T., Zadub rovskaya, I., Zadubrovskiy,P.,etal.(2015).Reproduction,agingandmortality rateinsocial subterranean mole voles ( Ellobius talpinus Pall.).Biogerontology 16, 723–732. doi:10.1007/s10522-015-9592-x" 46 309 W2324622141.pdf 2 3 separator 0.9742503 ¶ 309 311 W2324622141.pdf 2 4 bibliography 0.9973862 "Palmer, C. (2010). Animal Ethics in Context . New York, NY: Columbia University Press." 311 400 W2324622141.pdf 2 5 separator 0.96874046 ¶ 400 402 W2324622141.pdf 2 6 bibliography 0.9972569 "Quillfeldt,P.(2002).Seasonalandannualvariationinthediet ofbreedingandnon- breedingWilson’sstorm-petrelsonKingGeorgeIsland,SouthShetlan dIslands. Pol.Biol. 25,216–221.doi:10.1007/s00300-001-0332-0" 402 602 W2324622141.pdf 2 7 separator 0.98687553 ¶ 602 604 W2324622141.pdf 2 8 bibliography 0.9980221 "Riou,S.,Chastel,O.,Lacroix,A.,andHamer,K.C.(2010).Stres sandparentalcare: prolactinresponsestoacutestressthroughoutthebreedingcycleina long-lived bird.Gen.Comp.Endocrinol. 168,8–13.doi:10.1016/j.ygcen.2010.03.011" 604 821 W2324622141.pdf 2 9 separator 0.98314303 ¶ 821 823 W2324622141.pdf 2 10 bibliography 0.9979896 "Selva, N., Cortés-Avizanda, A., Lemus, J. A., Blanco, G., Mueller, T., Heinrich, B., et al. (2011). Stress associated with group living in a long-lived b ird.Biol. Lett. 7,608–610.doi:10.1098/rsbl.2010.1204Speakman, J. R., and Garratt, M. (2014). Oxidative stress as a cost of reproduction:beyondthesimplistictrade-offmodel. Bioessays 36,93–106.doi: 10.1002/bies.201300108" 823 1203 W2324622141.pdf 2 11 separator 0.99177146 ¶ 1203 1205 W2324622141.pdf 2 12 text 0.86306566 "Conflict of Interest Statement: The author declares that the research was conducted in the absence of any commercial or financial relations hips that could beconstruedasapotentialconflictofinterest." 1205 1405 W2324622141.pdf 2 13 separator 0.9882239 ¶ 1405 1407 W2324622141.pdf 2 14 paratext 0.9245309 "Copyright © 2016 Costantini. This is an open-access article dist ributed under the terms of the Creative Commons Attribution License (CC BY ). The use, distribution or reproduction in other forums is permitted, p rovided the original author(s) or licensor are credited and that the original pub lication in this journal is cited, in accordance with accepted academic prac tice. No use, distribution or reproduction is permitted which does not co mply with these terms." 1407 1888 W2324622141.pdf 2 15 separator 0.98779345 ¶ 1888 1890 W2324622141.pdf 2 16 paratext 0.9771328 Frontiers in Ecology and Evolution | www.frontiersin.org 3 February 2016 | Volume 4 | Article 10 1890 1987 W2324622141.pdf 2 0 paratext 0.9895903 Frontiers in Medicine 01 frontiersin.org 0 40 W4391819200.pdf 0 1 separator 0.98151606 ¶ 40 42 W4391819200.pdf 0 2 title 0.9884428 "Case report: Treatment of Wilson’s disease by human amniotic fluid administration" 42 130 W4391819200.pdf 0 3 separator 0.9908058 ¶ 130 132 W4391819200.pdf 0 4 contact 0.51296175 Libin 132 138 W4391819200.pdf 0 5 table 0.6596488 Liang 1, Hong Xin 2, Xueyan Shen 3, Yanping Xu 1, ¶ 138 191 W4391819200.pdf 0 6 contact 0.51423967 Lansen 191 198 W4391819200.pdf 0 7 table 0.6389332 Zhang 1, 198 207 W4391819200.pdf 0 8 contact 0.54028624 Dehui 207 213 W4391819200.pdf 0 9 table 0.58108824 Liu 1, 213 220 W4391819200.pdf 0 10 contact 0.6263735 Liling Zhao 1 and Xinglong Tong 220 252 W4391819200.pdf 0 11 table 0.51554877 253 254 W4391819200.pdf 0 12 contact 0.645292 ¶ 1* 254 258 W4391819200.pdf 0 13 separator 0.9186505 ¶ 258 260 W4391819200.pdf 0 14 contact 0.990081 "1 Qiaoxi Tong Xinglong Western Medical Clinic, Shijiazhuang, Hebei, China, 2 Department of Obstetrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China, 3 Department of Obstetrics, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China" 260 531 W4391819200.pdf 0 15 separator 0.9941617 ¶ 531 533 W4391819200.pdf 0 16 text 0.9982926 "Background: Wilson’s disease (WD) is not an uncommon genetic disease in clinical practice. However, the current WD therapies have limitations. The effectiveness of stem cell therapy in treating WD has yet to be verified, although a few animal studies have shown that stem cell transplantation could partially correct the abnormal metabolic phenotype of WD. In this case report, we present the therapeutic effect of human amniotic fluid containing stem cells in one WD patient." 533 1029 W4391819200.pdf 0 17 separator 0.9833837 ¶ 1029 1031 W4391819200.pdf 0 18 text 0.99945354 "Case presentation: A 22-year-old Chinese woman was diagnosed with WD 1 year ago in 2019. The available drugs were not effective in managing the progressive neuropsychiatric symptoms. We treated the patient with pre- cultured human amniotic fluid containing stem cells. Amniotic fluid was collected from pregnant women who underwent induced labor at a gestational age of 19–26 weeks, and then, the fluid was cultured for 2 h to allow stem cell expansion. Cultured amniotic fluid that contained amniotic fluid derived stem cells (AFSC) in the range of approximately 2.8–5.5 × 104/ml was administrated by IV infusion at a rate of 50–70 drops per minute after filtration with a 300- mu nylon mesh. Before the infusion of amniotic fluid, low-molecular-weight heparin and dexamethasone were successively administrated. The patient received a total of 12 applications of amniotic fluid from different pregnant women, and the treatment interval depended on the availability of amniotic fluid. The neuropsychiatric symptoms gradually improved after the stem cell treatment. Dystonia, which included tremor, chorea, dysphagia, dysarthria, and drooling, almost disappeared after 1.5 years of follow-up. The Unified Wilson’s Disease Rating Scale score of the patient decreased from 72 to 10." 1031 2365 W4391819200.pdf 0 19 separator 0.9090395 ¶ 2366 2368 W4391819200.pdf 0 20 text 0.9995021 "Brain magnetic resonance imaging (MRI) showed a reduction in the lesion area and alleviation of damage in the central nervous system, along with a partial recovery of the lesion to the normal condition. The serum ceruloplasmin level was elevated from undetectable to 30.8 mg/L, and the 24-h urinary copper excretion decreased from 171 to 37 μg. In addition, amniotic fluid transplantation also alleviates hematopoietic disorders. There were no adverse reactions during or after amniotic fluid administration." 2368 2897 W4391819200.pdf 0 21 separator 0.86586004 ¶ 2897 2899 W4391819200.pdf 0 22 text 0.9994526 "Conclusion: Amniotic fluid administration, through which stem cells were infused, significantly improves the clinical outcomes in the WD patient, and the finding may provide a novel approach for managing WD effectively." 2899 3126 W4391819200.pdf 0 23 separator 0.9956358 ¶ 3126 3128 W4391819200.pdf 0 24 paratext 0.5437048 KEYWORD 3128 3136 W4391819200.pdf 0 25 title 0.5054588 S 3136 3137 W4391819200.pdf 0 26 separator 0.8847583 ¶ 3137 3139 W4391819200.pdf 0 27 paratext 0.56079346 Wilson’s disease, amniotic fluid, stem cell, neuropsychiatric symptoms, case reportOPEN ACCESS 3139 3234 W4391819200.pdf 0 28 separator 0.9887686 ¶ 3234 3236 W4391819200.pdf 0 29 contact 0.98423195 "EDITED BY Ian James Martins, University of Western Australia, Australia REVIEWED BY Tomasz Litwin, Institute of Psychiatry and Neurology (IPiN), Poland Segundo Mariz, European Medicines Agency, Netherlands *CORRESPONDENCE Xinglong Tong xinglongtong@hotmail.com" 3236 3530 W4391819200.pdf 0 30 separator 0.8003132 ¶ 3530 3532 W4391819200.pdf 0 31 paratext 0.90143526 "RECEIVED 20 September 2023 ACCEPTED 24 January 2024 PUBLISHED 14 February 2024" 3532 3615 W4391819200.pdf 0 32 separator 0.98623514 ¶ 3615 3617 W4391819200.pdf 0 33 paratext 0.6250569 CITATION 3617 3626 W4391819200.pdf 0 34 separator 0.98639596 ¶ 3626 3628 W4391819200.pdf 0 35 bibliography 0.8664805 "Liang L, Xin H, Shen X, Xu Y, Zhang L, Liu D, Zhao L and Tong X (2024) Case report: Treatment of Wilson’s disease by human amniotic fluid administration. Front. Med." 3628 3805 W4391819200.pdf 0 36 paratext 0.6515845 11:1297457. 3806 3818 W4391819200.pdf 0 37 bibliography 0.40227422 3818 3819 W4391819200.pdf 0 38 paratext 0.62505496 ¶ doi: 10.3389/fmed.2024.1297457 3819 3851 W4391819200.pdf 0 39 separator 0.9799017 ¶ 3851 3853 W4391819200.pdf 0 40 paratext 0.9387556 "COPYRIGHT © 2024 Liang," 3853 3879 W4391819200.pdf 0 41 bibliography 0.63523775 Xin 3879 3883 W4391819200.pdf 0 42 paratext 0.80285513 , 3883 3884 W4391819200.pdf 0 43 bibliography 0.76497597 Shen 3884 3889 W4391819200.pdf 0 44 paratext 0.73138434 , 3889 3890 W4391819200.pdf 0 45 bibliography 0.8065208 Xu 3890 3893 W4391819200.pdf 0 46 paratext 0.7264002 , 3893 3894 W4391819200.pdf 0 47 bibliography 0.82660073 Zhang 3894 3900 W4391819200.pdf 0 48 paratext 0.7047615 , 3900 3901 W4391819200.pdf 0 49 bibliography 0.8167251 Liu 3901 3905 W4391819200.pdf 0 50 paratext 0.72623193 , 3905 3907 W4391819200.pdf 0 51 bibliography 0.75314105 Zhao 3907 3911 W4391819200.pdf 0 52 paratext 0.82858133 ¶ and 3912 3918 W4391819200.pdf 0 53 bibliography 0.5713394 Tong 3918 3923 W4391819200.pdf 0 54 paratext 0.9609412 ". This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.TYPE Case Report" 3923 4420 W4391819200.pdf 0 55 separator 0.6172323 4420 4421 W4391819200.pdf 0 56 paratext 0.9160022 "¶ PUBLISHED 14 February 2024 DOI 10.3389/fmed.2024.1297457" 4421 4482 W4391819200.pdf 0 0 paratext 0.9762364 Open Peer Review on Qeios 0 25 W4232694441.pdf 0 1 separator 0.725085 ¶ 25 27 W4232694441.pdf 0 2 paratext 0.9168868 Open Peer Review on Qeios 27 53 W4232694441.pdf 0 3 separator 0.94701195 ¶ 53 55 W4232694441.pdf 0 4 title 0.97866344 Unresectable Synovial Sarcoma 55 85 W4232694441.pdf 0 5 separator 0.95521355 ¶ 85 87 W4232694441.pdf 0 6 title 0.62582785 National Cancer Institute 87 113 W4232694441.pdf 0 7 separator 0.9632232 ¶ 113 115 W4232694441.pdf 0 8 paratext 0.72579527 Source 115 122 W4232694441.pdf 0 9 separator 0.847791 ¶ 122 124 W4232694441.pdf 0 10 paratext 0.50638986 National Cancer Institute. 124 151 W4232694441.pdf 0 11 separator 0.9141587 ¶ 152 154 W4232694441.pdf 0 12 paratext 0.44558206 Un 154 157 W4232694441.pdf 0 13 title 0.41598672 resectable 157 167 W4232694441.pdf 0 14 paratext 0.38717887 Syno 167 172 W4232694441.pdf 0 15 title 0.34157863 vial 172 176 W4232694441.pdf 0 16 paratext 0.34908676 Sarcoma 176 184 W4232694441.pdf 0 17 separator 0.51196384 ¶ 184 186 W4232694441.pdf 0 18 bibliography 0.28275332 186 187 W4232694441.pdf 0 19 paratext 0.5281361 . NCI Thesaurus. Code 187 208 W4232694441.pdf 0 20 separator 0.42282283 ¶ 208 210 W4232694441.pdf 0 21 paratext 0.44707087 C153074. 210 219 W4232694441.pdf 0 22 separator 0.9851256 ¶ 219 221 W4232694441.pdf 0 23 text 0.85432476 Synovial sarcoma that is not amenable to surgical resection. 221 282 W4232694441.pdf 0 24 separator 0.9794999 ¶ 282 284 W4232694441.pdf 0 25 paratext 0.92125875 "Qeios · Definition, February 2, 2020" 284 328 W4232694441.pdf 0 26 separator 0.6583266 ¶ 328 330 W4232694441.pdf 0 27 paratext 0.95236003 "Qeios ID: 4M2J2F · https://doi.org/10.32388/4M2J2F 1 /" 330 393 W4232694441.pdf 0 28 separator 0.85342467 ¶ 393 395 W4232694441.pdf 0 29 paratext 0.59739774 1 395 397 W4232694441.pdf 0 0 paratext 0.97715026 Open Peer Review on Qeios 0 25 W4232748661.pdf 0 1 separator 0.66813815 ¶ 25 27 W4232748661.pdf 0 2 paratext 0.93515205 Open Peer Review on Qeios 27 53 W4232748661.pdf 0 3 separator 0.95479286 ¶ 53 55 W4232748661.pdf 0 4 title 0.9797592 Protein Hormone Receptor 55 80 W4232748661.pdf 0 5 separator 0.95244926 ¶ 80 82 W4232748661.pdf 0 6 title 0.75647354 National Cancer Institute 82 108 W4232748661.pdf 0 7 separator 0.9717853 ¶ 108 110 W4232748661.pdf 0 8 paratext 0.69888866 Source 110 117 W4232748661.pdf 0 9 separator 0.7406073 ¶ 117 119 W4232748661.pdf 0 10 paratext 0.5011287 National Cancer Institute. 119 146 W4232748661.pdf 0 11 separator 0.7626606 ¶ 147 149 W4232748661.pdf 0 12 paratext 0.46754712 Protein Hormone Receptor 149 174 W4232748661.pdf 0 13 bibliography 0.30301154 174 175 W4232748661.pdf 0 14 separator 0.29912862 ¶ 175 176 W4232748661.pdf 0 15 bibliography 0.4408462 . 176 178 W4232748661.pdf 0 16 paratext 0.43343833 NCI Thesaurus. Code C18968. 178 206 W4232748661.pdf 0 17 separator 0.9940268 ¶ 206 208 W4232748661.pdf 0 18 text 0.9988493 "Typically associated with the cell membrane, Protein Hormone Receptors selectively bind with high affinity to genetically-encoded polymerized amino acids in peptide linkage that have regulatory effects on the activity of specific target cells. A ligand-induced conformational and functional change in the receptor alters its interaction with target molecules, leading to changes in cellular physiology through modification of the activity of signal transduction pathways." 208 690 W4232748661.pdf 0 19 separator 0.98661166 ¶ 690 692 W4232748661.pdf 0 20 paratext 0.95813507 "Qeios · Definition, February 2, 2020" 692 736 W4232748661.pdf 0 21 separator 0.5725328 736 737 W4232748661.pdf 0 22 paratext 0.9356973 "¶ Qeios ID: H4PKQ5 · https://doi.org/10.32388/H4PKQ5 1 /" 737 801 W4232748661.pdf 0 23 separator 0.7816408 ¶ 801 803 W4232748661.pdf 0 24 paratext 0.7045298 1 803 805 W4232748661.pdf 0 0 paratext 0.97997385 POSTER PRESENTATION Open Access 0 31 W2070214024.pdf 0 1 separator 0.9415248 ¶ 31 33 W2070214024.pdf 0 2 title 0.94466054 "Murine FLT3 ligand-derived dendritic cell-mediated early immune responses are critical to controllingcell-free human T cell leukemia virus type 1infection" 33 190 W2070214024.pdf 0 3 separator 0.98854554 ¶ 190 192 W2070214024.pdf 0 4 bibliography 0.7764054 Saifur Rahman, Zafar K Khan, Brian Wigdahl, Stephen Jennings, Frederic Tangy, Pooja Jain* 192 282 W2070214024.pdf 0 5 separator 0.958969 ¶ 282 284 W2070214024.pdf 0 6 paratext 0.6330211 From 16th International Conference on Human Retro 284 334 W2070214024.pdf 0 7 title 0.5144628 virus 334 339 W2070214024.pdf 0 8 paratext 0.47683716 es: 339 342 W2070214024.pdf 0 9 title 0.5460436 HTLV and 342 351 W2070214024.pdf 0 10 paratext 0.48416823 Related 351 359 W2070214024.pdf 0 11 title 0.50450295 Virus 359 365 W2070214024.pdf 0 12 paratext 0.507668 es 365 367 W2070214024.pdf 0 13 separator 0.8453686 ¶ 367 369 W2070214024.pdf 0 14 paratext 0.6598954 Montreal, Canada. 26-30 June 2013 369 403 W2070214024.pdf 0 15 separator 0.9879565 ¶ 403 405 W2070214024.pdf 0 16 text 0.9956374 "Human T cell leukemia virus type 1 (HTLV-1) is asso- ciated with two immunologi cally distinct diseases: HTLV-1-associated myelopathy/tropical spastic parapar- esis and adult T cell leukemia. We observed previously that depletion of dendritic cells (DCs) in CD11c-diphtheria toxin receptor transgenic mice followed by infection withcell-free virus led to greater proviral and Tax mRNA loadsand diminished cellular immune response compared withmice infected with cell-associated virus. To understandthe significance of these in vivo results and explore thehost-pathogen interaction between DCs and cell-freeHTLV-1, we used FLT3 ligand-cultured mouse bone mar- row-derived DCs (FL-DCs) and chimeric HTLV-1. Pheno- typically, the FL-DCs upregulated expression of surfacemarkers (CD80, CD86, and MHC class II) on infection,however, the level of MHC class I remained unchanged.We performed kinetic studies to understand viral entry,proviral integration, and exp ression of the viral protein Tax. Multiplex cytokine profiling revealed production ofan array of proinflammatory cytokines and type 1 IFN (IFN- a) by FL-DCs treated with virus. Virus-matured FL- DCs stimulated proliferation of autologous CD3(+) T cells as shown by intracellular nuclear Ki67 staining andproduced IFN- gwhen cultured with infected FL-DCs." 405 1739 W2070214024.pdf 0 17 separator 0.80247605 ¶ 1739 1741 W2070214024.pdf 0 18 text 0.99952215 Gene expression studies using type 1 IFN-specificand DC-specific arrays revealed upregulation of IFN-stimulated genes, most cytokines, and transcription fac-tors, but a distinct downregulation of many chemokines. 1741 1954 W2070214024.pdf 0 19 separator 0.556293 ¶ 1954 1956 W2070214024.pdf 0 20 text 0.996917 "Overall, these results highlight the critical early responsesgenerated by FL-DCs on challenge with cell-free chimeric HTLV-1." 1956 2084 W2070214024.pdf 0 21 separator 0.9489473 ¶ 2084 2086 W2070214024.pdf 0 22 paratext 0.9684657 "Published: 7 January 2014 doi:10.1186/1742-4690-11-S1-P70" 2086 2146 W2070214024.pdf 0 23 separator 0.84963536 ¶ 2146 2148 W2070214024.pdf 0 24 paratext 0.924753 "Cite this article as: Rahman et al .:Murine FLT3 ligand-derived dendritic cell-mediated early immune responses are critical to controlling cell-free human T cell leukemia virus type 1 infection. Retrovirology 2014 11(Suppl 1): P70." 2148 2386 W2070214024.pdf 0 25 separator 0.96796346 ¶ 2386 2388 W2070214024.pdf 0 26 paratext 0.5515305 Submit 2388 2395 W2070214024.pdf 0 27 text 0.4802404 your next manuscript to 2395 2419 W2070214024.pdf 0 28 paratext 0.41621214 BioMed 2419 2426 W2070214024.pdf 0 29 text 0.7988338 "Central and take full advantage of: • Convenient online submission • Thorough peer review• No space constraints or color figure charges• Immediate publication on acceptance• Inclusion in PubMed, CAS, Scopus and Google Scholar• Research which is freely available for redistribution" 2426 2713 W2070214024.pdf 0 30 separator 0.70287776 ¶ 2713 2715 W2070214024.pdf 0 31 contact 0.78994 "Submit your manuscript at www.biomedcentral.com/submitDrexel Institute for Biotechnology and Virology Research, and the Department of Microbiology and Immunology, Drexel University College of Medicine, Doylestown, PA, USA" 2715 2944 W2070214024.pdf 0 32 paratext 0.9794975 "Rahman et al .Retrovirology 2014, 11(Suppl 1):P70 http://www.retrovirology.com/content/11/S1/P70" 2944 3042 W2070214024.pdf 0 33 separator 0.51674235 ¶ 3042 3044 W2070214024.pdf 0 34 paratext 0.95574117 "© 2014 Rahman et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated." 3044 3556 W2070214024.pdf 0 0 paratext 0.99034554 Remote Sens. 2018 ,10, 2022 16 of 21 0 36 W2903685299.pdf 15 1 separator 0.99378 ¶ 36 38 W2903685299.pdf 15 2 text 0.9976546 "upon model-parameter recalibration. Generally, the recalibration of the model parameters effectively improved the hydrological potential of satellite precipitation, especially for precipitation products with small errors; however, this recalibration approach should be taken with a grain of salt because it may result in unrealistic parameter values in some cases [80,81]." 38 417 W2903685299.pdf 15 3 separator 0.9961032 ¶ 417 419 W2903685299.pdf 15 4 title 0.89090866 Table 6. Comparison of daily and monthly observed and simulated streamflow when the Variable 419 511 W2903685299.pdf 15 5 separator 0.8264605 ¶ 511 513 W2903685299.pdf 15 6 title 0.52154154 Infiltration Capacity 513 534 W2903685299.pdf 15 7 caption 0.44673225 (VIC) model was forced by the 534 564 W2903685299.pdf 15 8 title 0.4658832 gauge- and 564 576 W2903685299.pdf 15 9 caption 0.394629 satellite 576 585 W2903685299.pdf 15 10 title 0.4832379 - 585 586 W2903685299.pdf 15 11 caption 0.41450128 based 586 591 W2903685299.pdf 15 12 title 0.5155765 precipitation datasets 591 614 W2903685299.pdf 15 13 separator 0.5774684 ¶ 614 616 W2903685299.pdf 15 14 title 0.38573667 in 2015. 616 625 W2903685299.pdf 15 15 separator 0.9755187 ¶ 625 627 W2903685299.pdf 15 16 table 0.9810698 "Time ScalesPrecipitation ProductsBenchmarking Calibration Product-Specific Calibration NSE RB (%) RMSE (m3/s) NSE RB (%) RMSE (m3/s) Daily CGDPA 0.41 26.39 274.05 0.63 0.55 217.11 IMERG-UC" 627 825 W2903685299.pdf 15 0 paratext 0.88436204 © Italiano LinguaDue 2. 2021. D. Della 0 40 W4210576438.pdf 12 1 title 0.917328 "Pietra, Gli italianismi enogastronomici recenti nella lingua inglese: un’analisi sui corpora" 40 136 W4210576438.pdf 12 2 separator 0.93850535 "¶ ¶" 138 148 W4210576438.pdf 12 3 table 0.99333566 "389 EnTenTen15 NYTC BBCGF Pomodoro 1.593 7 9 Porchetta 481 8 7 Porcino 118 143 16 Prosciutto crudo 62 - - Prosecco 3.425 13 50 Puttanesca 279 15 16 Ribollita 157 9 - Rinfresco 6 - - Ristretto 29 1 - Robiola 88 2 - Rondinella 216 - - Rosticceria 30 - - Scamorza 110 - - Vongole 154 4 5 Zampone 44 - - ¶" 148 517 W4210576438.pdf 12 4 separator 0.98463523 ¶ ¶ 520 526 W4210576438.pdf 12 5 text 0.99920446 "Analizzando il numero di occorrenze è possibile notare come i lessemi compaiano più spesso nel corpus EnTenTen15 , vista la grandezza di quest’ultimo rispetto agli altri due ." 526 709 W4210576438.pdf 12 6 separator 0.80006266 ¶ 710 712 W4210576438.pdf 12 7 text 0.9994524 "Tuttavia, vi sono alcuni dati numerici da prendere in considerazione. Nel corpus appena citato gli italianismi che registrano più occorrenze e un numero superiore alle 3.000 sono: latte, barista , gelato, Bellini , calamari e prosecco ; i quali tuttavia non hanno una presenza così ricorrente nei corpora dei d ue enti di informazione. Ad eccezione dell’italianismo calamari il quale presenta ben 69 occorrenze per quanto concerne il NYTC e 10 nel BBCGF ." 712 1188 W4210576438.pdf 12 8 separator 0.94670665 ¶ 1189 1191 W4210576438.pdf 12 9 text 0.99951035 "Analogamente a calamari , vi sono alcuni lessemi che , in proporzione, risultano più presenti negli altri corpora : è il caso di porcino , biscotto oppure cannellini ." 1191 1363 W4210576438.pdf 12 10 separator 0.9726325 ¶ 1365 1367 W4210576438.pdf 12 11 text 0.99964917 "Osservando gli italianismi che occorrono di più nel NYTC si evince come i termini più ricorrenti siano: calzone (228), Parmigiano -Reggiano (228), crostini (188), porcino (143), penne (144) e cannellini (109). Per quanto riguarda il corpus ricavato da BBCGF il termine che registra più presenze è carbonara (75), seguito da frittata (71), cannellini (68) e penne (58)." 1367 1749 W4210576438.pdf 12 12 separator 0.9727738 ¶ 1751 1753 W4210576438.pdf 12 13 text 0.99943286 "Mettendo a confronto i risultati delle occorrenze dei corpora dei due enti di informazione è possibile constatare come il numero delle occorrenze nel NYTC sia numericamente superiore al BBCGF. Eppure, in alcuni italianismi tale tendenza non sussiste come accade con carbonara che registra 75 occorrenze contro le 17 del New York Times Cooking, amaretto (56-46) o Prosecco che appare 50 volte nel corpus britannico rispetto alle 13 del NYTC. Quest’ultimo dato è giustificato dalla condizione che il lessema vanta nell’inglese britannico, ovvero di proprietary name come testimoniato anche dall’ Oxford English Dictionary ." 1753 2402 W4210576438.pdf 12 14 separator 0.98918 ¶ ¶ 2404 2410 W4210576438.pdf 12 0 paratext 0.97738314 ©1921 Nature Publishing Group 0 29 W4244504558.pdf 0 0 paratext 0.98980457 Molecules 2023 ,28, 5424 2 of 14 0 32 W4384557681.pdf 1 1 separator 0.99276173 ¶ 32 34 W4384557681.pdf 1 2 text 0.9996799 "Later work in the same group showed that the use of palladium complexes with phenanthro- line ligands can also be employed for this aim, although the reaction was only performed on one specific substrate [ 20]. In the absence of phenanthroline, the reaction rate and selectivity were low [ 21]. Note that this is one of the few cyclization reactions of nitroarenes affording a 6-membered ring [ 10]. The large majority of these reactions afford 5-membered N-heterocycles." 34 515 W4384557681.pdf 1 3 separator 0.8902943 ¶ 515 517 W4384557681.pdf 1 4 text 0.9997241 "Despite the intrinsic advantages of this strategy, the need to employ pressurized CO and autoclaves has strongly limited its use by other groups. This problem is common to other carbonylation reactions, and in recent years several solid or liquid substances have been developed, so-called CO surrogates, which can liberate CO under the reaction condi- tions. This also allows the reaction to be performed in a thick-walled glass reactor [ 22–34]." 517 972 W4384557681.pdf 1 5 separator 0.85259026 ¶ 972 974 W4384557681.pdf 1 6 text 0.99976254 "In our group, we have developed the use of phenyl formate as a CO surrogate for the synthesis of several heterocycles [ 35–40]. During these studies, a single example of cycliza- tion of 20-nitro-4-methoxychalcone to the corresponding 4-quinolone in a 67% yield was reported, but this specific reaction was not investigated any further [ 38,39]. Very recently, we were able to also employ the HCOOH/Ac 2O mixture for this aim, thus eliminating the problem of the formation of phenol as a coproduct, whose complete separation was problematic in some cases [ 41]. The use of this mixture also improves the atom efficiency of the reaction, since phenyl formate is itself synthesized by the reaction of phenol with the HCOOH/Ac 2O mixture, although the use of gaseous CO is clearly unbeatable from this point of view." 974 1804 W4384557681.pdf 1 7 separator 0.9017416 ¶ 1804 1806 W4384557681.pdf 1 8 text 0.9997603 "The catalyst employed in the present work is a complex of palladium with 1,10-phenanthroline (Phen) as a ligand, which is formed in situ. These complexes were shown to be the most active and robust catalysts for reactions involving a reduction of nitroarenes, not only in the field of cyclization reactions [ 42–46] but also when the syn- thesis of base chemicals, such as carbamates and ureas [ 47–52] is involved, where very high turnover numbers are required to make the catalyst economically interesting. By employing this catalytic system together with the HCOOH/Ac 2O mixture, we were able to convert a series of 20-nitrochalcones ( 1) into the corresponding 4-quinolones ( 2) in high yields, with acetic acid and CO 2as the only stoichiometric byproducts. Moreover, the use of both pressurized CO and an autoclave is avoided, since the reaction can be performed in a thick-walled glass tube, a kind of apparatus that is cheap and commercially available in many sizes (Scheme 1)." 1806 2813 W4384557681.pdf 1 9 separator 0.9536263 ¶ 2813 2815 W4384557681.pdf 1 10 paratext 0.9832423 Molecules 2023 , 28, x FOR PEER REVIEW 2 of 15 2815 2862 W4384557681.pdf 1 11 separator 0.8537084 ¶ ¶ 2863 2869 W4384557681.pdf 1 12 text 0.99972355 "syntheses [19]. Later work in the same group showed that the use of palladium complexes with phenanthroline ligands can also be employed for this aim, although the reaction was only performed on one speci fic substrate [20]. In the absence of phenanthroline, the reaction rate and selectivity were low [21]. Note that this is one of the few cyclization reactions of nitroarenes a ffording a 6-membered ring [10]. The large majority of these reactions a fford 5-membered N-heterocycles." 2870 3368 W4384557681.pdf 1 13 separator 0.89882386 ¶ 3369 3371 W4384557681.pdf 1 14 text 0.99973214 "Despite the intrinsic advantages of this st rategy, the need to employ pressurized CO and autoclaves has strongly limited its use by other groups. This problem is common to other carbonylation reactions, and in recent ye ars several solid or liquid substances have been developed, so-called CO surrogates, which can liberate CO under the reaction conditions. This also allows the reaction to be performed in a thick-walled glass reactor [22–34]. In our group, we have developed the use of phenyl formate as a CO surrogate for the synthesis of several heterocycles [35–40]. During these studies, a single example of cyclization of 2 ′-nitro-4-methoxychalcone to the corresponding 4-quinolone in a 67% yield was reported, but this speci fic reaction was not investigated any further [38,39]. Very r e c e n t l y , w e w e r e a b l e t o a l s o e m p l o y t h e H C O O H / A c 2O mixture for this aim, thus eliminating the problem of the formation of phenol as a coproduct, whose complete separation was problematic in some cases [41] . The use of this mixture also improves the atom efficiency of the reaction, since phenyl format e is itself synthesized by the reaction of phenol with the HCOOH/Ac 2O mixture, although the use of gaseous CO is clearly unbeatable from this point of view." 3371 4710 W4384557681.pdf 1 15 separator 0.9548359 ¶ 4711 4713 W4384557681.pdf 1 16 text 0.9997612 "The catalyst employed in the present wo rk is a complex of palladium with 1,10- phenanthroline (Phen) as a ligand, which is formed in situ. These complexes were shown to be the most active and robust catalysts for reactions involving a reduction of nitroarenes, not only in the field of cyclization reactions [42–46] but also when the synthesis of base chemicals, such as carbamat es and ureas [47–52] is involved, where very high turnover numbers are required to make the catalyst economically interesting. By employing this catalytic system together with the HCOOH/Ac 2O mixture, we were able to convert a series of 2 ′-nitrochalcones ( 1) into the corresponding 4-quinolones ( 2) in high yields, with acetic acid and CO 2 as the only stoichiometric byproducts. Moreover, the use of both pressurized CO and an autoclave is avoided, since the reaction can be performed in a thick-walled glass tube, a kind of apparatus that is cheap and commercially available in many sizes (Scheme 1)." 4713 5732 W4384557681.pdf 1 17 separator 0.9923836 ¶ ¶ 5733 5739 W4384557681.pdf 1 18 caption 0.9084446 Scheme 1. Previous and present work. 5739 5776 W4384557681.pdf 1 19 separator 0.99007887 ¶ 5777 5779 W4384557681.pdf 1 20 title 0.99302816 2. Results and Discussion 5779 5805 W4384557681.pdf 1 21 separator 0.9757105 ¶ 5806 5808 W4384557681.pdf 1 22 title 0.99176353 2.1. Optimization of the Reaction Conditions 5808 5853 W4384557681.pdf 1 23 separator 0.9925842 ¶ 5854 5856 W4384557681.pdf 1 24 text 0.99974334 "As mentioned in the introduction, recently, some of us reported that phenyl formate can be used e ffe c t i v e l y a s a c a r b o n m o n o x i d e s o u r c e i n t h e c y c l i z a t i o n o f 2 ′-nitro-4- methoxychalcone to the corresponding 4-qu inolone [38,39]. The same unoptimized reaction conditions allowed the isolation of 2-phenylquinolin-4(1 H)-one ( 2a) in a 78% yield. Despite the satisfactory results, we directed our e ffort toward the optimization of a catalytic reaction in which the HCOOH/Ac 2O mixture acts as the CO source for the reasons mentioned in the Introduction." 5856 6475 W4384557681.pdf 1 25 separator 0.73213184 ¶ 6476 6478 W4384557681.pdf 1 26 text 0.9994757 "As a first attempt, the reaction conditions prev iously optimized for the reductive cyclization of o-nitrostyrenes were employed. The result was encouraging though not" 6478 6648 W4384557681.pdf 1 27 separator 0.926921 ¶ 6649 6651 W4384557681.pdf 1 28 caption 0.9552861 Scheme 1. Previous and present work. 6651 6688 W4384557681.pdf 1 29 separator 0.99007463 ¶ 6688 6690 W4384557681.pdf 1 30 title 0.9936534 2. Results and Discussion 6690 6716 W4384557681.pdf 1 31 separator 0.9658017 ¶ 6716 6718 W4384557681.pdf 1 32 title 0.9921473 2.1. Optimization of the Reaction Conditions 6718 6763 W4384557681.pdf 1 33 separator 0.9932736 ¶ 6763 6765 W4384557681.pdf 1 34 text 0.99975586 "As mentioned in the introduction, recently, some of us reported that phenyl for- mate can be used effectively as a carbon monoxide source in the cyclization of 20-nitro-4- methoxychalcone to the corresponding 4-quinolone [ 38,39]. The same unoptimized reaction conditions allowed the isolation of 2-phenylquinolin-4(1 H)-one ( 2a) in a 78% yield. Despite the satisfactory results, we directed our effort toward the optimization of a catalytic reaction in which the HCOOH/Ac 2O mixture acts as the CO source for the reasons mentioned in the Introduction." 6765 7331 W4384557681.pdf 1 35 separator 0.9469745 ¶ 7331 7333 W4384557681.pdf 1 36 text 0.99971837 "As a first attempt, the reaction conditions previously optimized for the reductive cyclization of o-nitrostyrenes were employed. The result was encouraging though not good (entry 1, Table 1); full conversion was reached but with a low 2ayield (51%). A higher selectivity was obtained using acetonitrile as the solvent at the same temperature (140C)" 7333 7688 W4384557681.pdf 1 0 paratext 0.98413426 292 0 3 W4383899762.pdf 16 1 separator 0.60742295 3 4 W4383899762.pdf 16 2 paratext 0.94424593 "¶ Revista Direitos, trabalho e política social, CUIABÁ, V. 9, n. 16, p . 276-294 Jan./jun. 2023lítica em foco . n. 64, 2018. Disponível em: https://repositorio. ipea.gov.br/bitstream/11058/8385/1/bmt_64_pol%C3%ADtica.pdf" 4 227 W4383899762.pdf 16 3 separator 0.6204777 ¶ 228 230 W4383899762.pdf 16 4 paratext 0.9382196 Acesso em: 20 abr. 2023. 230 255 W4383899762.pdf 16 5 separator 0.98926806 ¶ 255 257 W4383899762.pdf 16 6 bibliography 0.9972558 "BRASIL. [Decreto-lei no 2.848 (1940)]. Código Penal. Organiza - do por Jair Lot Vieira. São Paulo: Edipro, 2023." 257 372 W4383899762.pdf 16 7 separator 0.95634174 ¶ 372 374 W4383899762.pdf 16 8 bibliography 0.99744636 "BRASIL. Constituição da República Federativa do Brasil: de 5 de Outubro de 1988. 54. ed. São Paulo: Atlas, 2022." 374 490 W4383899762.pdf 16 9 separator 0.9852097 ¶ 490 492 W4383899762.pdf 16 10 bibliography 0.9418105 "BRASIL. Lei no 10.803, de 11 de dezembro de 2003. Altera o art. 149 do Decreto-Lei no 2.848, de 7 de dezembro de 1940 - Código Penal, para estabelecer penas ao crime nele tipificado e indicar as hipóteses em que se configura condição análoga à de escravo. Diá- rio Oficial da União , Brasília, 2003." 492 803 W4383899762.pdf 16 11 separator 0.99026364 ¶ 803 805 W4383899762.pdf 16 12 bibliography 0.9974267 "BRITO FILHO, José Claudio Monteiro. Trabalho decente: análise jurídica da exploração do trabalho – trabalho escravo e outras for - mas de trabalho indigno. 5. ed. São Paulo: LTr, 2018." 805 995 W4383899762.pdf 16 13 separator 0.9786842 ¶ 995 997 W4383899762.pdf 16 14 bibliography 0.99466914 "BRITO FILHO, José Claudio Monteiro de. Trabalho Escravo: caracterização Jurídica dos Modos Típicos e Execução. Revista Hendu, Belém, v .4, n. 1, p. 41-56, 2014. Disponível em: https:// periodicos.ufpa.br/index.php/hendu/article/view/1714/2135 Acesso em: 17 abr.2023." 997 1277 W4383899762.pdf 16 15 separator 0.99083465 ¶ 1277 1279 W4383899762.pdf 16 16 bibliography 0.99783266 "CHIZZOTTI, Antônio. Pesquisa qualitativa em ciências huma- nas e sociais. 6. ed. São Paulo: V ozes, 2014." 1279 1387 W4383899762.pdf 16 17 separator 0.976904 ¶ 1388 1390 W4383899762.pdf 16 18 bibliography 0.9978328 "COMPARATO, Fabio Konder. A afirmação histórica dos direitos humanos. 10. ed. São Paulo: Saraiva, 2019." 1390 1496 W4383899762.pdf 16 19 separator 0.9805555 ¶ 1497 1499 W4383899762.pdf 16 20 bibliography 0.99768764 "DALLARI, Dalmo de Abreu. Boletim de Associação Juízes para a Democracia , n. 15, ano 15, 1998." 1499 1597 W4383899762.pdf 16 0 paratext 0.9798069 349 0 3 W1683451372.pdf 5 1 separator 0.97619927 ¶ 3 5 W1683451372.pdf 5 2 text 0.6750201 "conhecimento científico, formando uma maneira própria e nova no processo ensino-aprendizagem (Lápis-La" 5 110 W1683451372.pdf 5 3 title 0.5076833 zúli 110 114 W1683451372.pdf 5 4 text 0.7817991 3). 114 118 W1683451372.pdf 5 5 separator 0.9755973 ¶ 118 120 W1683451372.pdf 5 6 text 0.9965242 "As falas acima retratam uma visão de Tecnologia Educacional restrita à educação formal. No entanto, é importante ter o claro entendimento deque esse tipo de tecnologia pode e deve ser utilizado em todo e qualquer espaço educativo, formal e informal, dentro e fora da assistência de enfermagem.A tecnologia tem eliminado progressivamente as barreiras físicas e temporais, facilitando a troca e a migração de idéias (12)." 120 554 W1683451372.pdf 5 7 separator 0.9956554 ¶ 554 556 W1683451372.pdf 5 8 title 0.9789176 "Tecnologia Educacional numa visão restrita de “ferramentas” para o aprendizado técnico" 556 645 W1683451372.pdf 5 9 separator 0.98760164 ¶ 645 647 W1683451372.pdf 5 10 text 0.99633485 "Nessa categoria, identificou-se apenas três (03) sujeitos que assim se expressaram: Seriam as técnicas utilizadas, as criações realizadas para os processos de aprendizagem (Mármore 1). Meio ou instrumento que você utiliza para acompanhar o grau de aprendizado (Quartzo Azul)." 647 933 W1683451372.pdf 5 11 separator 0.86094904 ¶ 933 935 W1683451372.pdf 5 12 text 0.99906737 "Essas falas sinalizam uma compreensão restrita no que tange à Tecnologia Educacional,enfatizando sua apropriação como um mero instrumento técnico que assegura a funcionalidade do processo ensino-aprendizagem. Esses meios são importantes no processo ensino-aprendizagem, mas a Tecnologia Educacional não se reduz à utilizaçãodesses meios. Ela precisa necessariamente ser um instrumento mediador entre o homem e o mundo, o homem e a educação, servindo de mecanismo peloqual o educando se apropria de um saber, redescobrindo e reconstruindo o conhecimento (8)." 935 1511 W1683451372.pdf 5 13 separator 0.9966786 ¶ 1511 1513 W1683451372.pdf 5 14 title 0.9818221 "Tecnologia Educacional como não apresentando clareza na expressão conceitual" 1513 1592 W1683451372.pdf 5 15 separator 0.99056804 ¶ 1592 1594 W1683451372.pdf 5 16 text 0.99433684 "Nessa situação, inserem-se cinco (05) docentes, os quais expressaram seu entendimento, denotando o não conhecimento da temática ou nãocompreensão da questão formulada, como exprimem as seguintes falas: É uma tecnologia que contribui com os aspectos educacionais e que deve ter momentos adequados para tal (Ágata 3). Penso que os recursos usados buscando modificar a realidade. São todas tecnologias educacionais (Lápis-Lazúli 2)." 1594 2040 W1683451372.pdf 5 17 separator 0.84867775 ¶ 2040 2042 W1683451372.pdf 5 18 text 0.9992437 "As falas denunciam a falta de nexo ao se referirem à temática investigada, permitindo inferirque o assunto constitui-se, ainda, num distanciamentodo processo de trabalho de muitos docentes das IES." 2042 2242 W1683451372.pdf 5 19 separator 0.98443246 ¶ 2242 2244 W1683451372.pdf 5 20 text 0.99809384 "A segunda concepção a ser discutida nesta reflexão diz respeito ao entendimento dos docentes em relação à Tecnologia Assistencial. Essa concepção ficou demonstrada nas manifestações expressadaspelos sujeitos participantes, das quais emergiram quatro categorias a seguir descritas e analisadas." 2244 2546 W1683451372.pdf 5 21 separator 0.99532264 ¶ 2546 2548 W1683451372.pdf 5 22 title 0.92559135 "Tecnologia Assistencial como sendo um conjunto de ações sistematizadas, processuais e instrumentais para a prestação de uma assistência qualificada" 2548 2700 W1683451372.pdf 5 23 separator 0.98957944 ¶ 2700 2702 W1683451372.pdf 5 24 text 0.99942845 "Essa concepção foi compartilhada por quinze (15) sujeitos, denotando um entendimento maisampliado da Tecnologia Assistencial, referindo-se a ela como processo sistematizado de ações e instrumentos, tendo em vista produzir uma assistênciacom maior qualidade. Os exemplos a seguir demonstram tais considerações." 2702 3020 W1683451372.pdf 5 25 separator 0.96391344 ¶ 3020 3022 W1683451372.pdf 5 26 text 0.99671894 "Ações desenvolvidas na assistência de enfermagem que visem a qualidade do cuidado prestado tanto no nível pessoal como profissional, proporcionando uma visão ética de cuidar do cuidador e tornando o cliente um cidadão (Cristal 1)." 3022 3259 W1683451372.pdf 5 27 separator 0.86796564 ¶ 3259 3261 W1683451372.pdf 5 28 text 0.9988205 "É todo o processo empreendido pelo enfermeiro junto a sua clientela, no seu dia-a-dia, mas desde que tenha sido avaliado através de uma pesquisa e que os resultados sejam conhecidos e aprovados e utilizados sistematicamente para beneficiar esta clientela (Ágata 5)." 3261 3535 W1683451372.pdf 5 29 separator 0.97480774 ¶ 3535 3537 W1683451372.pdf 5 30 text 0.99937916 "O desenvolvimento de tecnologias, e aqui em especial aquelas relativas ao cuidado de enfermagem, repercutiram e repercutem de duas formas: aprimeira, a mudança do tipo e da intensidade do cuidado de enfermagem, e a segunda, sobre o provimento do cuidado de enfermagem e aqueles queo prestam, já que papéis, valores e padrões de trabalho foram todos influenciados pelos níveis de tecnologia que estão em constante mutação. Portanto,é necessário o enfermeiro buscar a construção do seu próprio instrumental e conhecimento que estejam relacionados com a qualidade de vida, a maneira deadministrar a saúde, a enfermidade e os problemas daí decorrentes (1-14)." 3537 4213 W1683451372.pdf 5 31 separator 0.9929639 ¶ 4213 4215 W1683451372.pdf 5 32 title 0.5038605 Tecnologia Assistencial 4215 4239 W1683451372.pdf 5 33 text 0.5565851 como sendo a constru 4239 4260 W1683451372.pdf 5 34 title 0.44271126 ção 4260 4263 W1683451372.pdf 5 35 text 0.7097986 "de um saber técnico-científico resultante de pesquisas e da experiência cotidiana e/ou a aplicação de teorias " 4263 4378 W1683451372.pdf 5 36 separator 0.46108288 ¶ 4378 4379 W1683451372.pdf 5 37 text 0.9026644 "O entendimento de Tecnologia Assistencial centrado na produção de conhecimentos, oriundosda prática investigativa e interventiva se destacam" 4379 4522 W1683451372.pdf 5 38 paratext 0.91127276 "Rev Latino-am Enfermagem 2005 maio-junho; 13(3):344-53 www.eerp.usp.br/rlaeTecnologias educacionais, assistenciais..." 4522 4641 W1683451372.pdf 5 39 separator 0.9926126 ¶ 4641 4643 W1683451372.pdf 5 40 bibliography 0.99178624 Nietsche EA, Backes VMS, Colomé CLM, Ceratti RN, Ferraz F. 4643 4702 W1683451372.pdf 5 0 table 0.9907758 20 40 60 802004006008001000 0 27 W4361961974.pdf 0 1 separator 0.9241742 ¶ 27 29 W4361961974.pdf 0 2 table 0.9772001 "Vehicle 33 mg/kg PF-00299804 3.7 mg/kg PF-00299804 40 mg/kg CI-1033Rx: qDX14" 29 112 W4361961974.pdf 0 3 separator 0.85324955 ¶ 112 114 W4361961974.pdf 0 4 table 0.6049075 Day Post Tum 114 127 W4361961974.pdf 0 5 title 0.4827506 or ImplantTumor Volume 127 149 W4361961974.pdf 0 6 table 0.5891576 (mm3) A. 149 158 W4361961974.pdf 0 7 separator 0.53806883 ¶ 158 160 W4361961974.pdf 0 8 table 0.5344025 B. 160 163 W4361961974.pdf 0 9 separator 0.9665562 ¶ 163 165 W4361961974.pdf 0 10 caption 0.8934303 Supplemental Figure 3. Gonzales et al.20 30 40 165 212 W4361961974.pdf 0 11 table 0.5713342 50 212 215 W4361961974.pdf 0 12 caption 0.85643286 2004006008001000 215 231 W4361961974.pdf 0 13 separator 0.83174706 ¶ 231 233 W4361961974.pdf 0 14 table 0.9029044 "Vehicle 30 mg/kg PF-00299804 40 mg/kg CI-1033 Rx: qDX14" 233 295 W4361961974.pdf 0 15 separator 0.83659077 ¶ 295 297 W4361961974.pdf 0 16 caption 0.68730426 Day Post Tumor ImplantTumor Volume (mm3) 297 338 W4361961974.pdf 0 0 paratext 0.9873806 279 Rev. Biol. Trop. (Int. J. Trop. Biol. ISSN-0034-7744) Vol. 59 (1): 269-282, March 2011 0 90 W2080247090.pdf 10 1 text 0.99830145 "las matrices triangulares de distancias genética y geográfica, la significancia de este test fue alta, demostrado por la correlación positiva hallada (coeficiente de correlación Rxy=0.431, p<0.001, cuencas medias de los ríos Nare y Guatapé; Rxy=0.377, p<0.001, cuenca del río Nare), sugiriendo procesos de aislamiento por distancia en las poblaciones evaluadas (Peakall et al. 2003). En el modelo de aislamiento por distancia de Wright (1943), la población no está subdividida en subunidades donantes o receptoras de migrantes, ni es una unidad panmíctica. Los cruzamientos al azar están limitados por la distancia, de modo que los individuos tendrán una mayor probabilidad de aparearse con vecinos que con individuos más lejanos. De este modo, se pueden agrupar a los individuos en ""vecindarios"", áreas definidas por ""individuos centrales"" cuyos progenitores se pueden tratar como extraídos al azar (Wright 1943) y por lo tanto, si se requiere realizar repoblamientos de esta especie, se deberá tener más en cuenta las poblaciones vecinas que las poblaciones distanciadas genéticamente, para evitar una contaminación genética de la saba- leta de las cuencas medias de los ríos Nare y Guatapé en el oriente antioqueño." 90 1368 W2080247090.pdf 10 2 separator 0.99318326 ¶ 1368 1370 W2080247090.pdf 10 3 text 0.99968296 "El modelo de aislamiento por distancia asume que la discontinuidad en las poblacio- nes se produce por diversas causas. En este trabajo la discontinuidad en las poblaciones de B. henni se podría explicar por las barreras geográficas entre los sitios muestreados, sus barreras bióticas, pendientes de ríos muy altas y migraciones a corta distancia que realiza la especie (Jiménez et al. 1998), siendo el com- portamiento migratorio una de las causas más plausibles observadas en este trabajo. Se han realizado estudios de aislamiento por distan- cia en otras especies de peces. En Columbia Británica (Canadá), se encontró un fuerte aisla- miento por distancia en poblaciones del Salmón Oncorhynchus tshawytscha, en 22 localidades ubicadas entre Alaska y Columbia Británica, al evaluarse 32 sistemas de aloenzimas. Se encontró que la pendiente de la regresión fue -0.299 y r 2=0.385; p<0.001 (Guthrie & Wilmot 2004). Otro estudio en el norte de Europa, el cual evaluó poblaciones de salmón del Atlánti-co (Salmo salar), un análisis con aloenzimas y microsatélites también demostró un aislamiento por distancia entre las poblaciones bálticas y del atlántico (r=0.477; p=0.001 (Tonteri et al. 2005). En ambos casos, las barreras geográficas fueron las causas del aislamiento por distancia." 1370 2715 W2080247090.pdf 10 4 separator 0.98857564 ¶ 2716 2718 W2080247090.pdf 10 5 text 0.99967647 "También puede citarse el trabajo de Mulvey et al. (2002), quienes realizaron un test de Mantel de tres vías usando distancia genética, distancia geográfica y distancia de contaminantes entre pares de sitios. Este test se utilizó para inten- tar correlacionar diferencias en contaminación de sedimentos con PAH (polycyclic aromatic hydrocarbons; hidrocarburos policíclicos aro-máticos), con la distancia genética obtenida por marcadores isoenzimáticos entre las poblacio- nes evaluadas del pez Fundulus heteroclitus en diferentes sitios del estuario del río Elizabeth (virginia, USA). El test de Mantel indicó una correlación positiva pero no significativa esta-dísticamente (r=0.47, a =0.05), entre la diferen- cia en contaminación de PAH en sedimentos y la distancia genética entre poblaciones de nueve sitios evaluados. No obstante, coeficientes de correlación muy bajos y no significativos esta- dísticamente indicaron que no existía relación entre la distancia genética y geográfica en peces capturados a una escala geográfica inferior (Mulvey et al. 2002)." 2718 3827 W2080247090.pdf 10 6 separator 0.9916087 ¶ 3828 3830 W2080247090.pdf 10 7 text 0.9995524 "En otra investigación, Bay et al. (2008), evaluaron la diversidad genética y estructura genética en la región control I del ADN mito- condrial entre regiones y arrecifes en el pez arre- cifal Acanthochromis polyacanthus, el cual tiene amplio rango de distribución en la Gran Barrera de Coral de Australia. En este estudio se evalua- ron mediante test de Mantel (1 000 permutacio- nes), correlaciones entre matrices de distancias genéticas y geográficas de pares de poblaciones, utilizando para ello el programa GenAlEx 6 (Peakall & Smouse 2006). Los resultados de análisis para el modelo de aislamiento por dis- tancia de Wright (1943), indicaron que se halló correlación entre distancias genéticas y geográ- ficas solo para algunas de las áreas muestreadas (Φ ST vs. km: r=0.77, p=0.001). Sin embargo, esta correlación permaneció estadísticamente" 3830 4713 W2080247090.pdf 10 0 paratext 0.8245475 For Peer Review Only 0 20 W3176843794.pdf 0 1 separator 0.99280775 ¶ 20 22 W3176843794.pdf 0 2 title 0.8813585 1 Supplementary material 23 48 W3176843794.pdf 0 3 separator 0.7547695 "1 2 ¶" 49 60 W3176843794.pdf 0 4 caption 0.98767555 Figure S1. Individual oxycodone plasma concentrations for the 15 healthy participants. Data is from the study by 3 60 175 W3176843794.pdf 0 5 separator 0.9221469 ¶ 176 178 W3176843794.pdf 0 6 paratext 0.4424382 Ladebo et al. [1] 4 178 199 W3176843794.pdf 0 7 separator 0.50922614 ¶ 200 202 W3176843794.pdf 0 8 paratext 0.48767048 5 203 205 W3176843794.pdf 0 9 separator 0.64283943 ¶ 206 208 W3176843794.pdf 0 10 paratext 0.49305028 Reference: 208 219 W3176843794.pdf 0 11 bibliography 0.73827964 6 220 222 W3176843794.pdf 0 12 separator 0.79380417 ¶ 223 225 W3176843794.pdf 0 13 bibliography 0.99303305 "1. Ladebo L, Foster DJR, Abuhelwa AY, Upton RN, Kongstad KT, Drewes AM, Christrup 7 LL, Olesen AE. Population pharmacokinetic -pharmacodynamic modelling of liquid and 8 controlled- release formulations of oxycodone in healthy volunteers. Basic Clin Pharmacol 9 Toxicol. 2020;126:263–76." 225 521 W3176843794.pdf 0 14 paratext 0.820677 10 522 525 W3176843794.pdf 0 15 separator 0.7414297 ¶ 526 528 W3176843794.pdf 0 16 paratext 0.98974895 Page 31 of 55 528 542 W3176843794.pdf 0 17 separator 0.7717074 ¶ 542 544 W3176843794.pdf 0 18 paratext 0.8087276 http://mc.manuscriptcentral.com/gastro Email: 544 590 W3176843794.pdf 0 19 contact 0.4827922 I 590 592 W3176843794.pdf 0 20 paratext 0.48573178 GAS 592 595 W3176843794.pdf 0 21 contact 0.5505438 -pe 595 598 W3176843794.pdf 0 22 paratext 0.51615274 erreview 598 606 W3176843794.pdf 0 23 contact 0.5657194 @ 606 607 W3176843794.pdf 0 24 paratext 0.6053851 journals 607 615 W3176843794.pdf 0 25 contact 0.52752817 .tan 615 619 W3176843794.pdf 0 26 paratext 0.56459147 df 619 621 W3176843794.pdf 0 27 contact 0.51210535 .co 621 624 W3176843794.pdf 0 28 paratext 0.7393735 .ukScandinavian Journal of Gastroenterology 624 667 W3176843794.pdf 0 29 separator 0.97726655 ¶ 667 669 W3176843794.pdf 0 30 paratext 0.3919425 "1 2 " 669 676 W3176843794.pdf 0 31 table 0.3002561 ¶ 676 677 W3176843794.pdf 0 32 paratext 0.38606703 3 677 680 W3176843794.pdf 0 33 table 0.31581557 ¶ 680 681 W3176843794.pdf 0 34 paratext 0.5587135 "4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60" 681 958 W3176843794.pdf 0 0 paratext 0.97520673 Anais | I Seminário Latino -Americano de Estudos em Cultura - SEMLACult 0 71 W2784247465.pdf 6 1 separator 0.50897825 73 74 W2784247465.pdf 6 2 paratext 0.95446897 "¶ Actas | I Seminario Latinoamericano de Estudios en Cultura - SEMLACult 28, 29 e 30 de junho de 2017, Foz do Iguaçu/PR, Brasil | claec.org/semlacult" 74 228 W2784247465.pdf 6 3 separator 0.8260976 ¶ 230 232 W2784247465.pdf 6 4 paratext 0.56401503 Resum 232 238 W2784247465.pdf 6 5 title 0.5475404 os 238 241 W2784247465.pdf 6 6 paratext 0.55323076 Expandidos ¶ 241 255 W2784247465.pdf 6 7 separator 0.49420336 257 258 W2784247465.pdf 6 8 paratext 0.7930144 ¶ 7 258 261 W2784247465.pdf 6 9 separator 0.9810003 ¶ 262 264 W2784247465.pdf 6 10 bibliography 0.99789923 LABURTHE, P; WARNIER, JP. Etnologia -Antropologia . Petrópol is: Vozes, 2003, 3a edição. 265 354 W2784247465.pdf 6 11 separator 0.8334106 ¶ 356 358 W2784247465.pdf 6 12 bibliography 0.59154356 360 361 W2784247465.pdf 6 13 separator 0.6015516 ¶ 361 362 W2784247465.pdf 6 14 bibliography 0.9976867 "LAPLANTINE, F. Marcos para uma História do Pensamento Antropológico . IN Aprender Antropologia. Brasiliense. São Paulo:, 2003" 362 491 W2784247465.pdf 6 15 separator 0.85479957 ¶ ¶ 493 499 W2784247465.pdf 6 16 bibliography 0.99708676 "LESSA, M. L. Mercosul Cultural: desafios e perspectivas de uma política cultural . Mural Internacionao , Ano 01, no. 02, p. 50 – 58, 2010. Disponível em:< http://www.e - publicacoes.uerj.br/index.php/muralinternacional/article/view/5322/3923>. Acesso em 12 de julho de 2016." 499 782 W2784247465.pdf 6 17 separator 0.81768984 ¶ ¶ 784 790 W2784247465.pdf 6 18 bibliography 0.9975661 "MALDONADO, C. O Turismo rural comunitário na América Latina . In: Bartholo, Sansolo e Burszt n, Turismo de Base omunitária: diversidade de olhares e experi ncias brasileiras. Letra e imagem. Rio de Janeiro, 2009." 790 1016 W2784247465.pdf 6 19 separator 0.8452128 ¶ 1018 1020 W2784247465.pdf 6 20 bibliography 0.7376866 1022 1023 W2784247465.pdf 6 21 separator 0.4956911 ¶ 1023 1024 W2784247465.pdf 6 22 bibliography 0.9977795 "PARSONS, T. El sistema social . Disponível em: . Acesso em 31 de maio de 2016." 1024 1198 W2784247465.pdf 6 23 separator 0.8451596 ¶ 1200 1202 W2784247465.pdf 6 24 bibliography 0.6842654 1204 1205 W2784247465.pdf 6 25 separator 0.57579714 ¶ 1205 1206 W2784247465.pdf 6 26 bibliography 0.99741226 "SALAZAR, N. B. Antropología del turismo en países en desarrollo : análisis crítico de las culturas, poderes e identidades generados por el turismo. Traducción del manuscrito en inglés de María Luisa Valencia. Uni versidade da Pensilvânia – Estados Unidos, 2006. Disponível em: . Acesso em 20 de maio de 2016." 1206 1572 W2784247465.pdf 6 27 separator 0.89715856 ¶ ¶ 1574 1580 W2784247465.pdf 6 28 bibliography 0.9967721 "UNESCO. Curso virtual sobre registro e inventario del patrimonio cultural inmaterial . s/n, 2010." 1580 1681 W2784247465.pdf 6 29 separator 0.7087884 ¶ 1683 1685 W2784247465.pdf 6 30 bibliography 0.9839329 "¶ WALSH, C. Interculturalidad y decolonialidad : las insurgencias político -epistêmicas de refundar el Estado. Universidade Andina Símon Bolivar, Tábula Rasa, Colômbia, 2008." 1687 1865 W2784247465.pdf 6 31 separator 0.9899882 ¶ 1867 1869 W2784247465.pdf 6 0 caption 0.7321662 Figure 2 0 8 W4387266962.pdf 5 1 separator 0.99563396 ¶ 9 11 W4387266962.pdf 5 2 title 0.9628693 Pre-program Personal Statement Concerning Learning Outcomes 11 71 W4387266962.pdf 5 3 separator 0.9902028 ¶ ¶ 73 79 W4387266962.pdf 5 4 title 0.94406223 Post-program evaluation. 79 104 W4387266962.pdf 5 5 separator 0.91667193 ¶ ¶ 105 111 W4387266962.pdf 5 6 text 0.999247 "Post-program evaluative ratings. When asked to indicate their agreement level on a seven-point scale regarding whet her the student made valuable contributions to the capstone institution, the average rating of 14 mentors was 6.21, with a range from 4-7, 1 neutral and 13 in the agreement zone. Mentors all i ndicated that they were intere sted in hosting a future DSCPE student." 111 505 W4387266962.pdf 5 7 separator 0.9703821 ¶ 507 509 W4387266962.pdf 5 8 text 0.999334 "During the focus group session and in the survey , students were asked about their overall satisfaction with the capstone experience and th e DSCPE program on a seven-point scale. The average rating for the capstone was 5, and for the DSCPE program was 5.8. The ratings from both the mentors and students were indicators of a successful program, though there were some problems with the capstone program." 509 929 W4387266962.pdf 5 9 separator 0.995514 ¶ 931 933 W4387266962.pdf 5 0 paratext 0.98654515 Int. J. Mol. Sci. 2019 ,20, 1178 5 of 18 0 40 W2920575346.pdf 4 1 separator 0.7425276 ¶ 40 42 W2920575346.pdf 4 2 paratext 0.9882533 Int. J. Mol. Sci. 2019 , 20, 1178 5 of 18 42 85 W2920575346.pdf 4 3 separator 0.9881663 ¶ 86 88 W2920575346.pdf 4 4 text 0.9937234 "for Nrf2 and Histone-1 (H1) are shown; CO = CON, P = PAIR, CU = CUR. Bands are separated in instances when samples were not adjacent on sa me membrane. Analyses included 1-way ANOVA, box and whisker plots depict 95% confidence interval (CI)." 89 337 W2920575346.pdf 4 5 separator 0.9960895 ¶ 338 340 W2920575346.pdf 4 6 title 0.9648367 Table 2. Antioxidant status. 340 369 W2920575346.pdf 4 7 separator 0.8312961 ¶ 371 373 W2920575346.pdf 4 8 table 0.9952502 "CON PAIR CUR p-value Protein Expression Catalase 1.08 (0.83) 0.83 (0.53) 1.03 (0.35) 0.44 MnSOD 2.13 (1.21) 1.96 (0.93) 2.64 (1.52) 0.23 HO-1 2.38 (1.84) 3.42 (1.33) 3.28 (1.42) 0.17 TRX/TxNip 0.52 (0.48) 0.67 (0.60) 1.11 (0.84) 0.34 Activity Catalase 0.16 (0.07) 0.18 (0.10) 0.18 (0.07) 0.79 MnSOD 3.96 (1.34) 3.12 (1.65) 4.56 (1.57) 0.40 TAC 0.21 (0.10) 0.23 (0.10) 0.22 (0.07) 0.88" 374 796 W2920575346.pdf 4 9 separator 0.9885584 ¶ 797 799 W2920575346.pdf 4 10 title 0.5186227 Plantaris 799 810 W2920575346.pdf 4 11 text 0.71690434 "antioxidant status at 36 months of age (CON, PAIR, & CUR). Catalase, manganese superoxide dismutase (MnSOD), heme-oxygenase-1 (HO-1), an d thioredoxin/thioredoxi n-interacting-protein (TRX/TxNip) ratio protein expression (O.D); catalase (K/mg protein) and MnSOD (units/mg protein) activity; and total antioxidant capacity (TAC; mM/mg protein). Values are mean (SD)." 810 1181 W2920575346.pdf 4 12 separator 0.99586153 ¶ 1182 1184 W2920575346.pdf 4 13 title 0.99389 2.4. Skeletal Muscle Oxidative Stress 1184 1222 W2920575346.pdf 4 14 separator 0.9947227 ¶ 1224 1226 W2920575346.pdf 4 15 text 0.9994317 "The level of skeletal muscle 4-hydroxynonenal (4-HNE) adducts was similar among the animal groups ( p = 0.935, Figure 4A). Howeve r, 3-nitrotyrosine (3-NT) and protein carbonyls (PC) levels, which are indicative of oxidative damage and modifications to proteins, were significantly lower among CUR compared to PAIR ( p = 0.035 and p = 0.042 respectively, Figures 4B,C)." 1226 1603 W2920575346.pdf 4 16 separator 0.9899808 ¶ 1605 1607 W2920575346.pdf 4 17 table 0.69408214 "(A) ¶ (B)" 1607 1622 W2920575346.pdf 4 18 separator 0.7436156 "¶ ¶" 1623 1634 W2920575346.pdf 4 19 paratext 0.98263115 Int. J. Mol. Sci. 2019 , 20, 1178 6 of 18 1634 1677 W2920575346.pdf 4 20 separator 0.9244875 ¶ 1678 1680 W2920575346.pdf 4 21 table 0.37473837 (C) 1681 1685 W2920575346.pdf 4 22 separator 0.96755224 ¶ ¶ 1686 1692 W2920575346.pdf 4 23 caption 0.9912998 "Figure 4. Oxidative damage markers at 36 mont hs of age (CON, PAIR, & CUR): ( A) 4-hydroxynonenal (4-HNE) adducts, no significant differences were observed ( p = 0.935, n = 9/group); ( B) CUR showed lower 3-nitrotyrosine (3-NT) compared to PAIR (* p = 0.035, n = 9/group); ( C) CUR displayed lower levels of protein carbonyls (PC) compared to PAIR (* p = 0.042, n = 9/group); Representative images for 4-HNE adducts, 3-NT, and PC are shown; CO = CON, P = PAIR, CU = CUR. Bands are separated in instances when samples were not adjacent on same membrane. Arrows indicate prominent bands that were used for evaluation. Analyses included 1-way ANOVA, box and whisker plots depict 95% confidence interval (CI)." 1692 2420 W2920575346.pdf 4 24 separator 0.99644387 ¶ 2421 2423 W2920575346.pdf 4 25 title 0.9942302 2.5. Curcumin Administration via Osmotic Pumps: Complementary Study 2423 2491 W2920575346.pdf 4 26 separator 0.99466944 ¶ 2492 2494 W2920575346.pdf 4 27 text 0.9996081 "No significant difference in body mass or food consumption was observed between control and curcumin groups ( n = 3/group) ( p > 0.05). Notably, rats provided with curcumin showed greater plantaris mass (0.28 (0.02) vs. 0.22 (0.01) g, curcumin vs. control; p = 0.012). There was an apparent greater specific peak twitch (20.5 (8.9) vs. 16.1 (11.5) N/g, curcumin vs. control) and specific tetanic (65.2 (27.4) vs. 43.6 (22.8) N/g curcumin vs. control) te nsion response of the plantaris from curcumin supplemented animals. Differences in force producti on measures, however, di d not reach statistical significance." 2494 3128 W2920575346.pdf 4 28 separator 0.996885 ¶ 3129 3131 W2920575346.pdf 4 29 title 0.9913149 3. Discussion 3131 3145 W2920575346.pdf 4 30 separator 0.9959644 ¶ 3146 3148 W2920575346.pdf 4 31 text 0.9995575 "The primary aim of this study was to document the effects of prolonged dietary curcumin exposure on aged skeletal muscle using an animal model that reflects the time course of human sarcopenia. Rats displayed notable differences be tween the curcumin and pair-fed groups that included larger muscle mass and greater force prod uction. Additionally, greater nuclear levels of Nrf2 and lower oxidative protein damage were observed in curcumin-fed animals. However, no difference in any measure was observed between CU R and CON rats, suggesting that curcumin did not impart beneficial effects compared to ad libitum feeding with a normal diet. A discussion of these findings is presented in the following sections." 3148 3881 W2920575346.pdf 4 32 separator 0.99703795 ¶ 3882 3884 W2920575346.pdf 4 33 title 0.9937702 3.1. Rats Consuming Curcumin Showed Reduced Food Intake 3884 3940 W2920575346.pdf 4 34 separator 0.9941309 ¶ 3942 3944 W2920575346.pdf 4 35 text 0.99972075 "We made use of a 0.2% curcumin (by food weight ) intervention, which is similar to previous rat studies investigating efficacy of curcumin on a variety of tissues, including liver, adipose, and skeletal muscle [29–33]. This supplementation amount resulted in an average daily curcumin intake of ~77 mg, similar to what was reported by another study examining curcumin effects on liver and adipose tissue [33]. While curcumin’s bitter taste has been ac knowledged in the literature [34,35], a lower food intake among curcumin-fed rats has not been repo rted previously. However, since previous dietary curcumin supplementation studies involved younger animals [30,36] the current data are the first to show reduced food intake in aged rats. The lower food intake among CUR rats is suggestive that aged rats may be more sensitive to the bitterness of curcumin. Thus, the difference in food intake between the CUR and CON groups underscores the importance of including a pair-fed group in this" 3944 4947 W2920575346.pdf 4 36 separator 0.9085045 ¶ 4948 4950 W2920575346.pdf 4 37 caption 0.99235296 "Figure 4. Oxidative damage markers at 36 months of age (CON, PAIR, & CUR): ( A) 4-hydroxynonenal (4-HNE) adducts, no significant differences were observed ( p= 0.935, n= 9/group); ( B) CUR showed lower 3-nitrotyrosine (3-NT) compared to PAIR (* p= 0.035, n= 9/group); ( C) CUR displayed lower levels of protein carbonyls (PC) compared to PAIR (* p= 0.042, n= 9/group); Representative images for 4-HNE adducts, 3-NT, and PC are shown; CO = CON, P = PAIR, CU = CUR. Bands are separated in instances when samples were not adjacent on same membrane. Arrows indicate prominent bands that were used for evaluation. Analyses included 1-way ANOVA, box and whisker plots depict 95% confidence interval (CI)." 4950 5661 W2920575346.pdf 4 38 separator 0.99599195 ¶ 5661 5663 W2920575346.pdf 4 39 title 0.9944508 2.5. Curcumin Administration via Osmotic Pumps: Complementary Study 5663 5731 W2920575346.pdf 4 40 separator 0.9957768 ¶ 5731 5733 W2920575346.pdf 4 41 text 0.99943286 "No significant difference in body mass or food consumption was observed between control and curcumin groups ( n= 3/group) ( p> 0.05). Notably, rats provided with curcumin showed greater plantaris mass (0.28 (0.02) vs. 0.22 (0.01) g, curcumin vs. control; p= 0.012). There was an apparent greater specific peak twitch (20.5 (8.9) vs. 16.1 (11.5) N/g, curcumin vs. control) and specific tetanic (65.2 (27.4) vs. 43.6 (22.8) N/g curcumin vs. control) tension response of the plantaris" 5733 6220 W2920575346.pdf 4 0 text 0.9986082 "active surveillance was implemented for all inmates presenting with skin abscesses. Infection control staff provided educationfor the correctional facility staff regarding appropriate environ-mental cleaning procedures and improving inmate hygiene.The correctional facility nurses have since been in contactwith the infection control practitioners at a neighbouringhealth care facility to deal with issues following the outbreak.T wo isolated new patients have been identified since 2004;however, these have not resulted in transmission to otherinmates, leading us to assume that the infection controlsimposed are being followed." 0 631 W113705701.pdf 3 1 separator 0.9969369 ¶ 631 633 W113705701.pdf 3 2 title 0.9913859 Risk factors for CAMRSA infection 633 667 W113705701.pdf 3 3 separator 0.9962795 ¶ 667 669 W113705701.pdf 3 4 text 0.99973536 Four of five patients in the 2002 outbreak had spent time in cell-block A. Patients 3 and 4 had been cellmates, and patients 2and 3 had both shared a cell with an inmate who ‘assisted’ otherinmates by lancing boils and pimples. This inmate was not col-onized with MRSA, and did not develop MRSA infection. Noother epidemiological linkage between patients was identified. 669 1040 W113705701.pdf 3 5 separator 0.97173524 ¶ 1040 1042 W113705701.pdf 3 6 text 0.99956065 "In August 2002, 12 uninfected inmates in cellblock A vol- untarily completed questionnaires that were aimed at identify-ing risk factors for asymptomatic MRSA carriage. Screenedinmates ranged from 21 to 48 years of age. Four inmates (33%)had tattoos, and no inmates reported prior intravenous druguse. One inmate was a resident of a First Nations (Aboriginal)reserve. Eleven of 12 inmates (92%) had been previouslyincarcerated. Four inmates (33%) reported antibiotic use inthe preceding year, and three (25%) reported skin infectionsduring this same time period. Inmates were not questionedabout sexual practices. Thirteen inmates from cellblock Awere screened for staphylococcal carriage; two inmates hadmethicillin-susceptible S aureus identified on screening, but none were colonized with MRSA." 1042 1844 W113705701.pdf 3 7 separator 0.96903443 ¶ 1844 1846 W113705701.pdf 3 8 text 0.9994642 "In 2004, no epidemiological link was identified between patients 6 and 7. Patients 8 and 9 were both housed in cell-block B, where they were in direct contact with one anotherand developed symptoms within 24 h of each other. Patient 10was housed in a cellblock separate from any of the other patients. All of the patients identified in 2004 were screenedfor MRSA carriage in the nares, groin and rectum, and all werenegative with the exception of patient 10, who had concurrentfolliculitis in the groin. Patients 9 and 10 had been exposed tothe health care system, patient 9 had brief hospital visits forlacerations and patient 10 had an HIV infection complicatedby Pneumocystis jiroveci pneumonia requiring hospitalization in 1993. Neither of these individuals were identified as being col-onized with MRSA in hospital records. None of the inmateshad chronic medical conditions, with the exception ofpatient 10 who was HIV-positive. All inmates denied intra- venous drug use. Thus, the major identifiable risk factor forCAMRSA infection noted in this population was prior andcurrent incarceration in the Canadian penal system." 1846 2982 W113705701.pdf 3 9 separator 0.9974091 ¶ 2982 2984 W113705701.pdf 3 10 title 0.9910879 Laboratory results 2984 3003 W113705701.pdf 3 11 separator 0.99640477 ¶ 3003 3005 W113705701.pdf 3 12 text 0.99969524 "All five MRSA isolates in 2002 had identical antibiograms, withsusceptibility to ciprofloxacin, trimethoprim-sulfamethoxazole,rifampin, tetracycline, vancomycin and nitrofurantoin. Theoutbreak strain was resistant to erythromycin (minimalinhibitory concentration of 8 μg/mL) and resistant to all beta-lactam antibiotics (minimal inhibitory concentration greaterthan 8 μg/mL). All 10 isolates were identical by PFGE (Figure 2).However, PFGE revealed that outbreak isolates were distinctfrom the health care-associated Canadian MRSA-1 andCanadian MRSA-2 curr ently circulating in the city. The out- break strain has been identified as the Canadian community-acquired strain, Canadian MRSA-10 or USA 300 strain. In Canada, the MRSA-10 strain has been identified in outbreaksseen mainly in the western provinces (8)." 3005 3822 W113705701.pdf 3 13 separator 0.9240173 ¶ 3822 3824 W113705701.pdf 3 14 text 0.9977924 "Virulence factor analysis determined that the 2002 isolate was positive for the PVL gene, negative for enterotoxins A to D and negative for staphylococcal toxic shock toxin. The 2004isolates additionally possessed the PVL gene. SCCMec typing was not performed." 3824 4097 W113705701.pdf 3 15 separator 0.9964367 ¶ 4097 4099 W113705701.pdf 3 16 title 0.9912846 DISCUSSION 4099 4110 W113705701.pdf 3 17 separator 0.99683845 ¶ 4110 4112 W113705701.pdf 3 18 text 0.9997582 T wo outbreaks of SSTIs in a Canadian correctional facility arereported. The outbreak strain was identified as CanadianMRSA-10, which has the same PFGE pattern as USA 300,one of the outbreak strains seen in jails in the United States(1,2,7,15-19,20-22,28-31). 4112 4372 W113705701.pdf 3 19 separator 0.8217509 ¶ 4372 4374 W113705701.pdf 3 20 text 0.9997376 "CAMRSA has been identified in a number of prison facili- ties within Canada (8), the United States and elsewhere(9-12,28). While the apparent predilection of correctionalfacilities for CAMRSA is puzzling, factors such as crowding,medical comorbidities, poor hygiene and sharing of personalcare items in the correctional environment may enhancetransmission of the bacterium once it has been introduced. Wefailed to identify traditional risk factors for MRSA infection orcarriage in all but one affected individual in this outbreak; thelast identified patient had HIV infection with a distant historyof hospitalization, but had not had documented MRSA infec-tion at that time. The absence of risk factors is commonlyreported with CAMRSA (1,2,13-15). Personal contact andthe sharing of fomites, such as towels, has been linked to thedevelopment of MRSA SSTIs among athletes (4-6,32,33),men who have sex with men (33) and prison populations(10,11,33). Sharing of towels, bedding and clothing was common in this facility." 4374 5393 W113705701.pdf 3 21 paratext 0.81245726 Main et al 5393 5403 W113705701.pdf 3 22 separator 0.7189863 5403 5404 W113705701.pdf 3 23 paratext 0.9599595 ¶ Can J Infect Dis Med Microbiol Vol 16 No 6 November/December 2005 346 5404 5475 W113705701.pdf 3 24 separator 0.9948518 ¶ 5475 5477 W113705701.pdf 3 25 caption 0.99608415 "Figure 2) Pulsed-field gel electrophoresis of genomic DNA from methicillin-resistant Staphylococcus aureus isolates from a Canadian correctional facility. All inmate-derived strains had identical pulsed-fieldgel electrophoresis patterns. Patient numbers are indicated at the base ofeach row and correspond to the patient numbers indicated in Table 1 ." 5477 5833 W113705701.pdf 3 26 separator 0.9876672 ¶ 5833 5835 W113705701.pdf 3 27 paratext 0.98705596 M Molecular weight markersMain_9109.qxd 11/21/2005 9:50 AM Page 346 5835 5906 W113705701.pdf 3 0 paratext 0.9790459 "Citation: Goessler, T.; Kaluarachchi, Y. Smart Adaptive Homes and Their Potential to Improve Space Efficiency and Personalisation. Buildings 2023 , 13, 1132. https://doi.org/10.3390/ buildings13051132" 0 209 W4366829277.pdf 0 1 separator 0.98634225 ¶ 209 211 W4366829277.pdf 0 2 contact 0.7443943 "Academic Editors: Yingbin Feng, Srinath Perera, Robert Osei-Kyei, Ali Al-Ashwal, Md Kamrul Hassan, Sepani Senaratne, Wei Zhou, Sameera Wijesiri Pathirana and Brendan Kirkland" 211 394 W4366829277.pdf 0 3 separator 0.94191265 ¶ 394 396 W4366829277.pdf 0 4 paratext 0.9535213 "Received: 20 February 2023 Revised: 5 April 2023 Accepted: 12 April 2023 Published: 24 April 2023" 396 500 W4366829277.pdf 0 5 separator 0.7678033 ¶ 500 502 W4366829277.pdf 0 6 paratext 0.95188475 "Copyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)." 502 769 W4366829277.pdf 0 7 separator 0.98074543 ¶ 769 771 W4366829277.pdf 0 8 title 0.9631187 buildings 771 781 W4366829277.pdf 0 9 separator 0.47583303 781 782 W4366829277.pdf 0 10 title 0.88359904 ¶ Systematic Review 782 801 W4366829277.pdf 0 11 separator 0.676172 ¶ 801 803 W4366829277.pdf 0 12 title 0.97441465 "Smart Adaptive Homes and Their Potential to Improve Space Efficiency and Personalisation" 803 893 W4366829277.pdf 0 13 separator 0.97865516 ¶ 893 895 W4366829277.pdf 0 14 contact 0.99293864 "Thomas Goessler * and Yamuna Kaluarachchi * Manchester School of Architecture, Manchester Metropolitan University, All Saints Building, Manchester M15 6BH, UK *Correspondence: thomas.goessler@stu.mmu.ac.uk (T.G.); y.kaluarachchi@mmu.ac.uk (Y.K.)" 895 1147 W4366829277.pdf 0 15 separator 0.9945718 ¶ 1147 1149 W4366829277.pdf 0 16 text 0.99501425 "Abstract: Over the last decades, population growth in urban areas and the subsequent rise in demand for housing have resulted in significant space and housing shortages. This paper investigates the influence of smart technologies on small urban dwellings to make them flexible, adaptive and personalised. The study builds on the hypothesis that adaptive homes and smart technology could increase efficiency and space usage up to two to three times compared to a conventional apartment." 1149 1639 W4366829277.pdf 0 17 separator 0.7162273 ¶ 1639 1641 W4366829277.pdf 0 18 text 0.998991 "The present study encompasses a comprehensive semi-systematic literature review that includes several case studies of smart adaptive homes demonstrating various strategies that can be employed to enhance the functionality of small spaces while reducing the physical and psychological limitations associated with them. These strategies involve incorporating time-dependent functions and furniture, as well as division elements that can adapt to the changing needs of users in real-time. This review further categorises types of flexibility and adaptation regarding the size of the moving elements, the time that the transformation takes and whether it is performed manually (by a human) or automatically (by a machine). Results show that smart and adaptive technology can increase space efficiency by reducing the need for separate physical spaces for different activities. Smart technology substantially increases the versatility and multifunctionality of a room in all three dimensions and allows for adaptation and customisation for a variety of users." 1641 2714 W4366829277.pdf 0 19 separator 0.99439263 ¶ 2714 2716 W4366829277.pdf 0 20 text 0.46110716 "Keywords: adaptive homes; efficient spaces; flexibility; home automation; interactive architecture; micro-living; personalisation; resilience; smart homes; space short" 2716 2884 W4366829277.pdf 0 21 paratext 0.3135409 age 2884 2887 W4366829277.pdf 0 22 separator 0.99694777 ¶ 2887 2889 W4366829277.pdf 0 23 title 0.9834225 1. Introduction 2889 2905 W4366829277.pdf 0 24 separator 0.99531853 ¶ 2905 2907 W4366829277.pdf 0 25 text 0.99965835 "Over the recent decades, the population growth in urban areas and rising demand for housing have been accompanied by a sharp increase in space shortage and a loss of identity and personalisation in urban homes. According to the RIBA [ 1], the most prevalent cause of discontent with one’s home in the UK is lack of space. In major cities such as London, the housing demand is hardly met with adequate supply, leading to unaffordable rents, urban sprawl, transportation problems and sustainability issues [ 2]. Increasingly, ‘Micro-living’ concepts have been proposed as a possible solution for affordable residential spaces, when combined with smart technology and automation. Smart technology can help increase the quality of life, especially regarding the increase of functionality and personalisation [ 3]." 2907 3733 W4366829277.pdf 0 26 separator 0.5720468 3733 3734 W4366829277.pdf 0 27 text 0.99727315 "¶ By doing so, housing can overcome fixed layouts for specific functions and have the potential to become smart, adaptive as well as easy to personalise. This will allow homes to solve problems, alter furniture and layouts, make decisions and predict what users might require in advance [ 3]. The objective can be achieved by introducing actuators and forms of Artificial Intelligence (AI) such as a Bidirectional Associative Memory (BAM) neural network, which is a type of recurrent neural network that is commonly used for pattern recognition and associative memory. Bifurcations in a fractional-order BAM neural network can have important implications for the network’s behaviour and performance, and research in this area [ 4–7] influences several fields, including pattern recognition," 3734 4535 W4366829277.pdf 0 28 separator 0.73938113 ¶ 4535 4537 W4366829277.pdf 0 29 paratext 0.9867776 Buildings 2023 ,13, 1132. https://doi.org/10.3390/buildings13051132 https://www.mdpi.com/journal/buildings 4537 4644 W4366829277.pdf 0 0 paratext 0.9813802 35 Problems of Economics and Law 2023, t. 8, nr 1 0 50 W4387912625.pdf 3 1 title 0.98972136 Analiza i ocena wielkości zużytego sprzętu elektrycznego i elektronicznego w Unii Europejskiej 50 145 W4387912625.pdf 3 2 separator 0.9954393 ¶ 145 147 W4387912625.pdf 3 3 caption 0.99534744 "Rysunek 1. Wskaźnik zebranego zużytego sprzętu elektrycznego i elektronicznego w 2020 roku do średniej masy sprzętu wprowadzonego do obrotu w trzech poprzednich latach (2017–2019) (w %)" 147 336 W4387912625.pdf 3 4 separator 0.82565796 ¶ 336 338 W4387912625.pdf 3 5 caption 0.9918517 Ź r ó d ł o: Eurostat, 2020. 338 367 W4387912625.pdf 3 6 separator 0.98282063 ¶ 368 370 W4387912625.pdf 3 7 text 0.99445754 "Wartości powyżej ustalonego poziomu 45% przekroczyło w 2020 roku 15 państw, w tym Polska. Jednocześnie cel na poziomie 65% osiągnęły jedynie trzy państwa: Bułgaria, Chorwacja i Finlandia. Najmniejsze wielkości zaobserwowano w Portugalii, Włoszech oraz Słowenii." 370 641 W4387912625.pdf 3 8 separator 0.98153865 ¶ 641 643 W4387912625.pdf 3 9 text 0.99951077 "Jak wynika z raportu opublikowanego przez organizację non-profit, WEEE Forum, zrze- szającą 50 organizacji reprezentujących producentów sprzętu elektrycznego i elektroniczne- go, w 2021 roku średnia produkcja elektroodpadów na mieszkańca Europy wynosiła 19,6 kg, a formalna zbiórka elektrosprzętu – 10,5 kg na jednego mieszkańca (rysunek 2). Urządzenia, które zostały poddane nieformalnej utylizacji wynosiły w 2021 roku 2,7 kg/mieszkańca, zaś 1,5 kg/mieszkańca zostało wyrzucone jako odpady komunalne. Nielegalny eksport oraz urzą- dzenia wywiezione do ponownego użytku szacuje się na poziomie 1,0 kg/mieszkańca. Z kolei 2,9 kg/mieszkańca stanowi nieznany przepływ elektroodpadów." 643 1343 W4387912625.pdf 3 10 separator 0.9957807 ¶ 1343 1345 W4387912625.pdf 3 0 paratext 0.9892278 Int. J. Environ. Res. Public Health 2017 ,14, 1383 7 of 11 0 58 W2769602039.pdf 6 1 separator 0.9949476 ¶ 58 60 W2769602039.pdf 6 2 text 0.99759924 "for CVD mortality due to cold in China [ 13]. The differences in findings might be due to the different populations and climates." 60 191 W2769602039.pdf 6 3 separator 0.6147053 ¶ 191 193 W2769602039.pdf 6 4 text 0.9988641 Our study showed the impact of temperature on CVD death was higher at high humidity. 193 278 W2769602039.pdf 6 5 separator 0.6221956 ¶ 278 280 W2769602039.pdf 6 6 text 0.99745977 "High humidity may lead to increased thrombotic risk [ 22], exacerbating the temperature effects on those with existing cardiac health problems. Our study found a positive correlation between daily CVD death and relative humidity (r = 0.035, p< 0.05), and a negative correlation between daily CVD death and daily mean temperature (r =" 280 620 W2769602039.pdf 6 0 text 0.99670374 "fact that the two conditions (diabetes and hypertension) may cause each other [2,3]. This finding is in agreement with several other studies [12,19,20]. This study also revealed that walking for at least ten minutes continu- ously everyday was negatively associated with hyperten- sion. This study further strengthens the previous reports in this country [9,11]." 0 374 W1963850250.pdf 5 1 separator 0.99307287 ¶ 374 376 W1963850250.pdf 5 2 text 0.99814564 "Unlike other studies done so far [11,16,17,22], cigarette smoking, harmful use of alcohol and excessive use of salt were not significantly associated with hypertension in this study. This may be due to the low prevalence of these factors in the community studied." 376 648 W1963850250.pdf 5 3 separator 0.9926744 ¶ 648 650 W1963850250.pdf 5 4 text 0.99944794 "This study has potential limitations. Firstly, being a cross-sectional one it has inherent limitation; hyperten- sion might have preceded some of the explanatory vari- ables. Second, this study is limited to behavioral and physical measurements, and did not include biochemical measurements such as a 24 hours urine sodium concen- tration, serum glucose level, etc. Thirdly, it was only lim- ited to adults aged 35 or older which made comparisons with other studies difficult." 650 1143 W1963850250.pdf 5 5 separator 0.99659956 ¶ 1143 1145 W1963850250.pdf 5 6 title 0.9796301 Conclusion 1145 1156 W1963850250.pdf 5 7 separator 0.9956964 ¶ 1156 1158 W1963850250.pdf 5 8 text 0.99924535 "There was high prevalence of hypertension among adults in Gondar and may show a hidden epidemic in this population. A significant proportion (37%) of parti- cipants were unaware of having the condition (screened newly for the first time) before they were identified by the current study." 1158 1456 W1963850250.pdf 5 9 separator 0.97469234 ¶ 1456 1458 W1963850250.pdf 5 10 text 0.9974476 "Family history of hypertension, self reported diabetes, obesity, physical inactivity and age were associated factors with hypertension. Hence, we recommend the design and implementation of community based screen- ing programs for hypertension in this community." 1458 1728 W1963850250.pdf 5 11 separator 0.9955989 ¶ 1728 1730 W1963850250.pdf 5 12 title 0.95864004 Competing interests 1730 1750 W1963850250.pdf 5 13 separator 0.9862325 ¶ 1750 1752 W1963850250.pdf 5 14 text 0.98016167 The authors declare that they have no conflict of interests. 1752 1813 W1963850250.pdf 5 15 separator 0.99288815 ¶ 1813 1815 W1963850250.pdf 5 16 title 0.966263 Authors ’contributions 1815 1838 W1963850250.pdf 5 17 separator 0.98398006 ¶ 1838 1840 W1963850250.pdf 5 18 text 0.97747296 "AA wrote the proposal, participated in data collection, analyzed the data and drafted the paper. BM and TA approved the proposal with some revisions, participated in data collection, analysis and manuscript writing. SA participated in data collection and manuscript editing. All authors read and approved the final manuscript." 1840 2175 W1963850250.pdf 5 19 separator 0.9957452 ¶ 2175 2177 W1963850250.pdf 5 20 title 0.9358681 Acknowledgements 2177 2194 W1963850250.pdf 5 21 separator 0.9912785 ¶ 2194 2196 W1963850250.pdf 5 22 text 0.98886126 "We appreciate the Chronic Disease Project at the University of Gondar referral hospital for financial support of this study. We also extend our hearted thanks to study participants and data collectors." 2196 2402 W1963850250.pdf 5 23 separator 0.9958909 ¶ 2402 2404 W1963850250.pdf 5 24 title 0.5238539 Author details 2404 2419 W1963850250.pdf 5 25 separator 0.9818593 ¶ 2419 2421 W1963850250.pdf 5 26 contact 0.9861385 "1Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.2Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia." 2421 2717 W1963850250.pdf 5 27 separator 0.92014897 ¶ 2717 2719 W1963850250.pdf 5 28 paratext 0.9577505 "Received: 21 August 2012 Accepted: 22 November 2012 Published: 28 November 2012References" 2719 2811 W1963850250.pdf 5 29 separator 0.98565906 ¶ 2811 2813 W1963850250.pdf 5 30 bibliography 0.9971156 "1. Alwan A: Global status report on noncommunicable diseases 2010 . Geneva, Switzerland: World Health Organization; 2010:2 –17." 2813 2943 W1963850250.pdf 5 31 separator 0.68662333 ¶ 2943 2945 W1963850250.pdf 5 32 bibliography 0.997132 "2. Kotcher T: Harrison's Principles of internal medicine .I nHypertensive vascular disease . Volume 2 17th edition. Edited by Athonys F, Eugene B, Dennis K. USA: McGraw-Hill Companies; 2008:1549 –1562." 2945 3151 W1963850250.pdf 5 33 separator 0.94414556 ¶ 3151 3153 W1963850250.pdf 5 34 bibliography 0.9977316 "3. Mathers C, Stevens G, Mascarenhas M: Global health risks: mortality and burden of disease attributable to selected major risks . Geneva, Switzerland: World Health Organization; 2009." 3153 3343 W1963850250.pdf 5 35 separator 0.9232105 ¶ 3343 3345 W1963850250.pdf 5 36 bibliography 0.99773073 "4. Opie LH, Seedat YK: Hypertension in sub-saharan African populations. Circulation 2005, 112(23):3562 –3568." 3345 3457 W1963850250.pdf 5 37 separator 0.9285792 ¶ 3457 3459 W1963850250.pdf 5 38 bibliography 0.9977191 "5. Tesfaye F: Epidemiology of cardiovascular disease risk factors in Ethiopia: the rural –urban gradient. J Hum Hypertens 2007, 21(2):28 –37." 3459 3603 W1963850250.pdf 5 39 separator 0.9210591 ¶ 3603 3605 W1963850250.pdf 5 40 bibliography 0.997327 "6. CSA: Summary and Statistical report of the 2007 Population and Housing Census . Addis Ababa, Ethiopia: Population and Housing Census Commission; 2008:57 –60." 3605 3770 W1963850250.pdf 5 41 separator 0.95098805 ¶ 3770 3772 W1963850250.pdf 5 42 bibliography 0.9974266 "7. WHO: WHO STEPwise approach to chronic disease risk factor surveillance (STEPS) . Geneva,Switzerland: WHO; 2005." 3772 3889 W1963850250.pdf 5 43 separator 0.9075099 ¶ 3889 3891 W1963850250.pdf 5 44 bibliography 0.9978679 "8. Chockalingam A, Campbell NR, Fodor JG: Worldwide epidemic of hypertension. Can J Cardiol 2006, 7(22):553 –555." 3891 4007 W1963850250.pdf 5 45 separator 0.93533707 ¶ 4007 4009 W1963850250.pdf 5 46 bibliography 0.99718285 "9. Tesfaye F, Byass P, Wall S: Population based prevalence of high blood pressure among adults in Addis Ababa: uncovering a silent epidemic. BMC Cardiovasc Disord 2009, 9:39." 4009 4188 W1963850250.pdf 5 47 separator 0.9646615 ¶ 4188 4190 W1963850250.pdf 5 48 bibliography 0.9980315 "10. Ong KL, Cheung BM, Man YB, Lau CP, Lam KS: Prevalence, awareness, treatment, and control of hypertension among United States adults 1999 –2004. Hypertension 2007, 49(1):69 –75." 4190 4375 W1963850250.pdf 5 49 separator 0.95055807 ¶ 4375 4377 W1963850250.pdf 5 50 bibliography 0.9977942 "11. Giday A, Tadesse B: Prevalence and determinants of hypertension in rural and urban areas of southern Ethiopia. Ethiop Med J 2011, 49(2):139 –147." 4377 4529 W1963850250.pdf 5 51 separator 0.95126593 ¶ 4529 4531 W1963850250.pdf 5 52 bibliography 0.9977657 "12. Shishani K, Dajani R, Khader Y: Hypertension risk assessment in the largest ethnic groups in Jordan . J Immigrant Minority: Health; 2011." 4531 4675 W1963850250.pdf 5 53 separator 0.94675106 ¶ 4675 4677 W1963850250.pdf 5 54 bibliography 0.9977272 "13. Van H, Byass P, Chuc N, Wall S: Gender differences in prevalence and socioeconomic determinants of hypertension: findings from the WHO STEPs survey in a rural community of Vietnam. J Hum Hypertens 2006, 20(2):109 –115." 4677 4906 W1963850250.pdf 5 55 separator 0.97664624 ¶ 4906 4908 W1963850250.pdf 5 56 bibliography 0.99743396 "14. Damasceno A, Azevedo A, Silva-Matos C, Prista A, Diogo D, Lunet N: Hypertension prevalence, awareness, treatment, and control in mozambique: urban/rural gap during epidemiological transition. Hypertension 2009, 54(1):77 –83." 4908 5143 W1963850250.pdf 5 57 separator 0.97272766 ¶ 5143 5145 W1963850250.pdf 5 58 bibliography 0.99765694 "15. Ahaneku GI, Osuji CU, Anisiuba BC, Ikeh VO, Oguejiofor OC, Ahaneku JE: Evaluation of bloods pressure and indices of obesity in a typical rural community eastern Nigeria. Ann Afr Med 2011, 10(2):120 –126." 5145 5357 W1963850250.pdf 5 59 separator 0.96181667 ¶ 5357 5359 W1963850250.pdf 5 60 bibliography 0.99781257 "16. Midha T, Idris MZ, Saran RK, Srivastav AK, Singh SK: Prevalence and determinants of hypertension in the urban and rural population of a north Indian district. East Afr J Public Health 2009, 6(3):268 –273." 5359 5572 W1963850250.pdf 5 61 separator 0.96197486 ¶ 5572 5574 W1963850250.pdf 5 62 bibliography 0.9977026 "17. Wamala JF, Karyabakabo Z, Ndungutse D, Guwatudde D: Prevalence factors associated with hypertension in rukungiri district, Uganda –a community- based study. Afr Health Sci 2009, 9(3):153 –160." 5574 5775 W1963850250.pdf 5 63 separator 0.9732703 ¶ 5775 5777 W1963850250.pdf 5 64 bibliography 0.99764484 "18. Mufunda J, Mebrahtu G, Usman A, Nyarango P, Kosia A, Ghebrat Y, Ogbamariam A: The prevalence of hypertension and its relationship with obesity: results from a national blood pressure survey in Eritrea. J Hum Hypertens 2006, 20(1):59 –65." 5777 6025 W1963850250.pdf 5 65 separator 0.955042 ¶ 6025 6027 W1963850250.pdf 5 66 bibliography 0.9976981 "19. Rodrigues A, Ferreti A: Arterial hypertension in the elderly of Bridgetown, Barbados:prevalence and associated factors. J Aging Health 2010, 22(5):611 –630." 6027 6192 W1963850250.pdf 5 67 separator 0.9577249 ¶ 6192 6194 W1963850250.pdf 5 68 bibliography 0.99755126 "20. Tamiru S, Alemseged F: Risk factors for cardiovascular diseases among diabetic patients in southwest Ethiopia. Ethiop J Health Sci 2010, 20(2):121 –128." 6194 6355 W1963850250.pdf 5 69 separator 0.9676161 ¶ 6355 6357 W1963850250.pdf 5 70 bibliography 0.9977909 "21. Jewell H, Monika M, Stefan G, Mark J, Young-II K, Sharima D, Cora E, Catrina I:Alcohol consumption in young adults and incident hypertension: 20-year follow-up from the coronary artery risk development in young adults study. Am J Epidemiol 2010, 17(5):532 –539." 6357 6629 W1963850250.pdf 5 71 separator 0.96022165 ¶ 6629 6631 W1963850250.pdf 5 72 bibliography 0.9978852 "22. Bowman T, Gaziano J, Buring J, Sesso H: A prospective study of cigarette smoking and risk of incident hypertension in women. J Am Coll Cardiol 2007, 50(21):2085 –2092." 6631 6807 W1963850250.pdf 5 73 separator 0.92752606 ¶ 6807 6809 W1963850250.pdf 5 74 bibliography 0.9279635 doi:10.1186/1471-2261-12-113 6809 6838 W1963850250.pdf 5 75 separator 0.92545056 ¶ 6838 6840 W1963850250.pdf 5 76 paratext 0.9308469 "Cite this article as: Awoke et al. :Prevalence and associated factors of hypertension among adults in Gondar, Northwest Ethiopia: a community based cross-sectional study. BMC Cardiovascular Disorders 2012 12:113.Awoke et al. BMC Cardiovascular Disorders 2012, 12:113 Page 6 of 6 http://www.biomedcentral.com/1471-2261/12/113" 6840 7173 W1963850250.pdf 5 0 paratext 0.96710044 "10 Vol:.(1234567890) Scientific Reports | (2022) 12:10698 | https://doi.org/10.1038/s41598-022-14934-z www.nature.com/scientificreports/useful for inhibiting inflammation in IBD and autoimmune diseases, such as rheumatoid arthritis, resulting in long-term control of inflammation39." 0 299 W4283332901.pdf 9 1 separator 0.9934767 ¶ 299 301 W4283332901.pdf 9 2 text 0.9996907 "As anaerobic culture conditions mimic intestinal environments, aerobic conditions are disadvantageous for their survival. In this study, we compared the production of proinflammatory cytokines by the DC line between aerobic and anaerobic conditions using this in vitro culture model. In the present study, we used anaerobic bac- teria (F. varium , F. nucleatum , B. vulgatus , and C. clostridioforme ) and facultative anaerobes (E. coli). High levels of IL-6, IL-8, or TNF-α were produced by the DC line stimulated with E. coli under both aerobic and anaerobic conditions. Both aerobic and anaerobic conditions may not be disadvantageous for E. coli. However, significantly higher IL-6, IL-8, or TNF-α levels were produced by the DC line stimulated with E. coli under aerobic conditions than under anaerobic conditions. Therefore, the E. coli strain used in this study may be capable of significantly stimulating the DC line under aerobic conditions. Presumably, this trend varies depending on the strain used." 301 1336 W4283332901.pdf 9 3 separator 0.98729396 ¶ 1337 1339 W4283332901.pdf 9 4 text 0.9997426 "Fusobacteria ( F. varium and F. nucleatum ) stimulated the DC line to produce significantly higher IL-6, IL-8, or TNF-α levels under anaerobic conditions than under aerobic conditions. Therefore, anaerobic bacteria, such as F. varium and F. nucleatum , are better stimulators of the DC line under anaerobic conditions that mimic intestinal environments. However, an anaerobic bacterium, B. vulgatus, promoted significantly more IL-8 and TNF-α production by the DC line under aerobic conditions than under anaerobic conditions. Since the number of anaerobic bacteria did not change significantly after 4 h of aerobic stimulation, the production of proinflam - matory cytokines is unlikely to involve dead bacteria. The ability of live anaerobic bacteria to stimulate the DC line under aerobic or anaerobic conditions may differ. The effect of fusobacteria on the DC line should be evalu- ated under anaerobic conditions similar to the colonic environment, since fusobacteria stimulation significantly increased the production of proinflammatory cytokines by the DC line under anaerobic conditions." 1339 2463 W4283332901.pdf 9 5 separator 0.9902481 ¶ 2463 2465 W4283332901.pdf 9 6 text 0.9830997 We further discussed the effects of F. varium and F. nucleatum on the DC line under anaerobic conditions. 2465 2573 W4283332901.pdf 9 7 separator 0.9878717 ¶ 2574 2576 W4283332901.pdf 9 8 text 0.99973446 "Compared to F. varium , F. nucleatum stimulated the DC line, as evidenced by the upregulation of surface mol - ecules on the DC line and production of IL-6, IL-8, or TNF-α at significantly higher levels. Previous studies have indicated an association between F. nucleatum and the progression of advanced CRC 21,32. Components of the human gut microbiota, such as F. nucleatum, may contribute to the etiology of advanced CRC, not only via the procarcinogenic activities of F. nucleatum but also via the effect of wider microbe-induced proinflammation45." 2576 3145 W4283332901.pdf 9 9 separator 0.94671094 ¶ 3146 3148 W4283332901.pdf 9 10 text 0.9997544 "Furthermore, F. varium is one of the pathogens causing UC6,12,24. The F. varium- stimulated DC line produced high levels of IL-6, IL-8, or TNF-α, consistent with our previous report indicating that F. varium in actively inflamed colonic mucosa was associated with the progression of UC36 and the pathogenesis of colorectal adenoma and intramucosal CRC 25. E. coli, F. nucleatum, and F. varium, which induce the production of high levels of proin - flammatory cytokines from activated DCs, may be potential pathogens causing various inflammatory diseases or cancers." 3148 3734 W4283332901.pdf 9 11 separator 0.9787203 ¶ 3734 3736 W4283332901.pdf 9 12 text 0.99974465 "Although the intestinal tract is an anaerobic environment and most intestinal bacteria are anaerobic bacteria, crosstalk between intestinal bacteria and immune cells, including DCs, has previously been evaluated under aerobic conditions. This study is significant as the first paper to analyze this process under anaerobic condi- tions. Under anaerobic conditions similar to intestinal environments, E. coli , F. nucleatum, and F. varium were the stimulatory commensal bacteria affecting the DC line. The next step of the research is to analyze the effects of commensal anaerobic bacteria on autologous immune-related cells, including DCs and T cells, from patients with IBD or CRC. Identification of the mechanisms by which anaerobic bacteria affect the patient’s immune system and cause disease is important." 3736 4567 W4283332901.pdf 9 13 separator 0.9943514 ¶ 4567 4569 W4283332901.pdf 9 14 title 0.9845525 Methods 4569 4577 W4283332901.pdf 9 15 separator 0.9966295 ¶ 4577 4579 W4283332901.pdf 9 16 text 0.9996385 "Cells and conditioned medium. The human DC line (PMDC05) has myeloid activity in the human DC lineage and functions as an APC to induce immunomodulation16,18. This line was a kind gift from Dr. Takahashi (Laboratory of Hematology and Oncology, Graduate School of Health Sciences, Niigata University, Niigata, Japan). The DC line was maintained in Iscove’s modified Dulbecco’s medium (IMDM) (Sigma–Aldrich; Merck KGaA, Darmstadt, Germany) supplemented with 100 U/mL penicillin, 100 μg/mL streptomycin (Wako Pure Chemical Industries, Ltd., Osaka, Japan) and 10% fetal calf serum (FCS) (Cytiva, Marlborough, MA, United States) under aerobic conditions in a humidified CO2 incubator (5% CO2 at 37 °C)." 4579 5298 W4283332901.pdf 9 17 separator 0.9878932 ¶ 5298 5300 W4283332901.pdf 9 18 text 0.9994875 "Preparation of commensal bacteria. Human commensal bacteria were obtained from the American Type Culture Collection (ATCC, Rockville, MD, United States) or Japan Collection of Microorganisms (JCM, RIKEN, Wako, Japan): F. varium (ATCC8501), F. nucleatum (ATCC25586), B vulgatus (JCM5826), C. clostridi - oforme (JCM1219), and E. coli (JCM1649). As these bacteria invade colonic epithelial cells and activate early intracellular signaling pathways to trigger host inflammation6, we selected these bacteria in the present study." 5300 5841 W4283332901.pdf 9 19 separator 0.9723073 ¶ 5842 5844 W4283332901.pdf 9 20 text 0.9996028 "Moreover, a probiotic, L. bulgaricus (LB-021001; Meiji Dairies), was used as a control. E. coli was harvested from BTB agar plates (Eiken Chemical Co. Ltd., Tokyo, Japan). B. vulgatus was harvested from Bacteroides agar plates (Nissui Chemical Co. Ltd., Tokyo, Japan). C. clostridioforme and L. bulgaricus were harvested from ABCM agar plates (Eiken Chemical Co. Ltd.). F. nucleatum and F. varium were harvested from FM agar-modified plates (Nissui Chemical Co. Ltd., Tokyo, Japan). These plates were cultured at 37 °C for 24–48 h. Facultative anaerobes (E. coli) were incubated under aerobic conditions in a humidified CO2 incubator (5% CO2 at 37 °C). Anaerobic bacteria (F. varium , F. nucleatum , B. vulgatus , and C. clostridioforme ) and facultative anaerobes (L. bulgaricus) were incubated in a gas generator for anaerobic culture using Anaeropack Kenki (Mitsubishi Gas Chemical Co., Inc., Tokyo, Japan) (< 0.1% O2, > 16% CO2 at 37 °C). After culture, the colonies were collected using a disposable plastic loop and suspended at a density of 1 × 108 colony forming units (CFUs)/mL in IMDM without antibiotics or FCS." 5844 7005 W4283332901.pdf 9 0 text 0.99809974 "patterns with different number of masks. As we suspect, using T(yMM)pattern gives a much better results than T(yM). However combination of two- mask patterns results in just slightly higher score and one-mask pattern M(yT)even outperforms MM (yT)." 0 257 W4283446307.pdf 7 1 separator 0.996163 ¶ 257 259 W4283446307.pdf 7 2 caption 0.99051815 "Figure 4: Comparison patterns with and without brack- ets." 259 320 W4283446307.pdf 7 3 separator 0.9898388 ¶ 320 322 W4283446307.pdf 7 4 caption 0.99166775 "Figure 5: Comparison patterns with and without brack- ets." 322 383 W4283446307.pdf 7 5 separator 0.9948418 ¶ 383 385 W4283446307.pdf 7 6 title 0.9901596 A.3 Patterns without brackets and dashes 385 426 W4283446307.pdf 7 7 separator 0.99532413 ¶ 426 428 W4283446307.pdf 7 8 text 0.9994638 "In the patterns discussed above we have extra dashes which were added by mistake and poten- tially could affect the results, so firstly we removethem from patterns. Also we have assumption that using brackets is not common thing in Spanish so such patterns could spoil generated substitutes and final results. To prove it we decide to compare y-based patterns with and without brackets and dashes." 428 840 W4283446307.pdf 7 9 separator 0.8338609 ¶ 840 842 W4283446307.pdf 7 10 text 0.99855053 "In the Figures 4 and 5 we can see that in all cases refusal to use brackets and dashes improves our results quite well, especially the right pat- tern get around 0.1 growth in JSD,SPR and COM- PARE,SPR scores.172" 842 1063 W4283446307.pdf 7 0 paratext 0.95857126 "BioMedResearchInternational 9 and National Science and Technology Major Project funded projects(Grant2013ZX10004202002)." 0 124 W2014541984.pdf 8 1 separator 0.9748171 ¶ 124 126 W2014541984.pdf 8 2 title 0.60697067 References 126 137 W2014541984.pdf 8 3 separator 0.98282516 ¶ 137 139 W2014541984.pdf 8 4 bibliography 0.99780124 "[1] R. P. Ryan, S. Monchy, M. 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Chauhan, S. Green, A. Pathak, J. Thomas, and R. Venka- tramanan, “Whole-genome sequences of five oyster-associated bacteriashowpotentialforcrudeoilhydrocarbondegradation,” Genome Announcements , vol. 1, no. 5, Article ID e00802-13, 2013.[15] F.Lira,A.Hern ́andez,E.Beldaetal.,“Whole-genomesequence ofStenotrophomonas maltophilia D457, a clinical isolate and a modelstrain,” JournalofBacteriology ,vol.194,no.13,pp.3563– 3564,2012." 3118 3571 W2014541984.pdf 8 31 separator 0.9541127 ¶ 3571 3573 W2014541984.pdf 8 32 bibliography 0.9976139 "[16] L.Zhang,M.Morrison,P.O.Cu ́ıv ,P .Evans,andC.M.Rickard, “ G e n o m es e q u e n c eo f Stenotrophomonas maltophilia strain AU12-09, isolated from an intravascular catheter,” Genome Announcements ,vol.1,no .3,2013." 3573 3799 W2014541984.pdf 8 33 separator 0.9178166 ¶ 3799 3801 W2014541984.pdf 8 34 bibliography 0.9978836 "[17] R. Banerjee and D. Roy, “Codon usage and gene expression patternof Stenotrophomonasmaltophilia R551-3forpathogenic modeofliving,” BiochemicalandBiophysicalResearchCommu- nications,vol.390,no .2,pp .177 –181,2009 ." 3801 4026 W2014541984.pdf 8 35 separator 0.9726396 ¶ 4026 4028 W2014541984.pdf 8 36 bibliography 0.9976845 "[ 1 8 ]M .A d a m e k ,J .O v e r h a g e ,S .B a t h e ,J .W i n t e r ,R .F i s c h e r , and T. Schwartz, “Genotyping of environmental and clinical Stenotrophomonas maltophilia isolates and their pathogenic potentia,” PLoSONE ,vol.6,no.11,ArticleIDe27615,2011." 4028 4298 W2014541984.pdf 8 37 separator 0.94798887 ¶ 4298 4300 W2014541984.pdf 8 38 bibliography 0.99811715 "[19] A. L. Delcher, A. Phillippy, J. Carlton, and S. L. Salzberg, “Fast algorithmsforlarge-scalegenomealignmentandcomparison,”NucleicAcidsResearch ,vol.30,no.11,pp.2478–2483,2002." 4300 4482 W2014541984.pdf 8 39 separator 0.9300894 ¶ 4482 4484 W2014541984.pdf 8 40 bibliography 0.9981147 "[20] A. G. McArthur, N. Waglechner, F. Nizam et al., “The com- prehensiveantibioticresistancedatabase,” AntimicrobialAgents andChemotherapy ,vol.57 ,no .7 ,pp .3348–3357 ,2013." 4484 4665 W2014541984.pdf 8 41 separator 0.9743578 ¶ 4665 4667 W2014541984.pdf 8 42 bibliography 0.99446416 "[ 2 1 ]L .L .Ch a n g,H .F .Ch e n ,C .Y .Ch a n g,T .M .Lee ,a n dW .J .W u , “Contribution of integrons, and SmeABC and SmeDEF efflux pumps to multidrug resistance in clinical isolates of Stenotrop- homonas maltophilia ,”Journal of Antimicrobial Chemotherapy , vol.53,no .3,pp .518–521,2004." 4667 4969 W2014541984.pdf 8 43 separator 0.97525823 ¶ 4969 4971 W2014541984.pdf 8 44 bibliography 0.9970722 "[ 2 2 ]H .W .S t o k e sa n dR .M .H a l l ,“ An o v e lf a m i l yo fp o t e n t i a l l y mobile DNA elements encoding site-specific gene-integration functions:integrons,” MolecularMicrobiology ,vol.3,no .12,pp . 1669–1683,1989." 4971 5208 W2014541984.pdf 8 45 separator 0.9662218 ¶ 5208 5210 W2014541984.pdf 8 46 bibliography 0.9979747 "[23] A. 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Schmitz, “Class 1 integrons, gene cassettes, mobility,andepidemiology,” EuropeanJournalofClinicalMicr- obiology&InfectiousDiseases ,vol.18,no .11,pp .7 61 –770,1999 ." 5210 5408 W2014541984.pdf 8 47 separator 0.9539268 ¶ 5408 5410 W2014541984.pdf 8 48 bibliography 0.99740297 "[24] R.Barbolla,M.Catalano,B.E.Ormanetal.,“Class1integrons increase trimethoprim-sulfamethoxazole MICs against epide-miologically unrelated Stenotrophomonas maltophilia isolates,” AntimicrobialAgentsandChemotherapy ,vol.48,no.2,pp.666– 669,2004." 5410 5662 W2014541984.pdf 8 49 separator 0.9649552 ¶ 5662 5664 W2014541984.pdf 8 50 bibliography 0.9976812 "[25] M.A.Toleman,P.M.Bennett,D.M.C.Bennett,R.N.Jones,and T.R.Walsh,“Globalemergenceoftrimethoprim/sulfamethox- azole resistance in Stenotrophomonas maltophilia mediated by acquisition of sulgenes,”Emerging Infectious Diseases ,v o l .1 3 , no.4,pp.559–565,2007." 5664 5934 W2014541984.pdf 8 51 separator 0.931716 ¶ 5934 5936 W2014541984.pdf 8 52 bibliography 0.9980002 "[26] G.A.Jacoby,“Mechanismsofresistancetoquinolones,” Clinical Infectious Diseases ,vol.41,supplement2,pp.S120–S126,2005." 5936 6060 W2014541984.pdf 8 53 separator 0.935907 ¶ 6060 6062 W2014541984.pdf 8 54 bibliography 0.9979098 "[27] A. Alonso and J. L. Mart ́ınez, “Multiple antibiotic resistance inStenotrophomonas maltophilia ,”Antimicrobial Agents and Chemotherapy ,vol.41,no .5,pp .1140–1142,1997 ." 6062 6241 W2014541984.pdf 8 55 separator 0.9512311 ¶ 6241 6243 W2014541984.pdf 8 56 bibliography 0.9977862 "[28] L. McMurry, R. E. Petrucci Jr., and S. B. Levy, “Active efflux oftetracyclineencodedbyfourgeneticallydifferenttetracyline resistance determinants in Escherichia coli ,”Proceedings of the National Academy of Sciences of the United States of America , vol.77,no.7,pp.3974–3977,1980." 6243 6537 W2014541984.pdf 8 57 separator 0.95939064 ¶ 6537 6539 W2014541984.pdf 8 58 bibliography 0.9978248 "[29] J.L.Martinez,M.B.S ́anchez,L.Mart ́ınez-Solanoetal.,“Func- tional role of bacterial multidrug efflux pumps in microbial naturalecosystems,” FEMSMicrobiologyReviews ,vol.33,no .2, pp .430–449 ,2009 ." 6539 6749 W2014541984.pdf 8 59 separator 0.95348805 ¶ 6749 6751 W2014541984.pdf 8 60 bibliography 0.9975787 "[30]M.F errer -N avarro ,R.Planell,D .Y eroetal.,“ A bundanceofthe quorum-sensing factor Ax21 in four strains of correlates with mortality rate in a New Zebrafish model of infection,” PLoS ONE,vol.8,no .6,ArticleIDe67207 ,2013." 6751 6985 W2014541984.pdf 8 0 text 0.9994498 "solution to the cells for 5 min and the cells were washed 3X with PBS. For blocking experi- ments, cells were incubated with the inhibitors Chlorpromazine (CPZ) (inhibitor of clathrin mediated endocytosis) and Methyl- β-cyclodextrin (mhCD) (inhibitor of caveolae mediated en- docytosis) prior to incubation with liposomes." 0 328 W2318910005.pdf 3 1 separator 0.99032354 ¶ 328 330 W2318910005.pdf 3 2 text 0.9994561 "Flow cytometric analysis for fluorescent signal from liposomes was performed using a 4-color FACS-Calibur (Becton Dickinson, Heidelberg, Germany) equipped with an argon laser exciting at a wavelength of 488 nm. For each sample, 10000 events were collected by list-modedata that consisted of side scatter, forward scatter and fluorescence emission centered at 530 nm (FL1) and 585 nm (FL2), respectively. For 7-Annexin V Apoptosis detection (AAD), a long-pass filter with a cutoff of 670 nm (FL3) was applied. The fluorescence was collected on alogarithmic scale with a 1024 channel resolution. Cell Quest Pro software (Becton Dickinson, Heidelberg, Germany) was applied for the analyses." 330 1028 W2318910005.pdf 3 3 separator 0.9972275 ¶ 1028 1030 W2318910005.pdf 3 4 title 0.99178106 Statistical analysis 1030 1051 W2318910005.pdf 3 5 separator 0.99633825 ¶ 1051 1053 W2318910005.pdf 3 6 text 0.9996947 "Statistical analysis was performed using GraphPad Prism, 4.03 (San Diego). One way analysisof variance (ANOVA) followed by Dunnett ’s post hoc used for other parameters. Data was ex- pressed in means ± S.E.M. P <0.05 was fixed as the statistical significance criterion." 1053 1325 W2318910005.pdf 3 7 separator 0.9968382 ¶ 1325 1327 W2318910005.pdf 3 8 title 0.9828181 Results 1327 1335 W2318910005.pdf 3 9 separator 0.95533764 ¶ 1335 1337 W2318910005.pdf 3 10 title 0.9803686 In vitro study 1337 1352 W2318910005.pdf 3 11 separator 0.9943192 ¶ 1352 1354 W2318910005.pdf 3 12 text 0.99972314 "Ultrastructural studies of UROtsa cells showed that cells lie adjacent to one another in a mono- layer arrangement and are connected to one another with finger like projections called as later- al interdigitation (LI). The size of nucleus in UROtsa cell is comparatively larger with highernuclear to cytoplasmic ratio. UROtsa cells incubated with colloidal gold particles in absence ofliposomes did not internalize any of the gold particles as indicated by dark grains lying outside the cell on EM image representing gold particles (G) ( Fig. 1 ). Compared to faint to dark grey color of uranyl acetate staining acquired by other cell organelles, the electron dense gold parti-cles appear as dark grains. Inscribed area in panel A and B is magnified 3 times further in panel C and D, respectively to show a single cell. The cellular uptake of gold particles was not affected by temperature as evident from the EM images of cells taken after incubation at 37°C (PanelA&C) or at 4°C (Panel B&D) for 2 h." 1354 2368 W2318910005.pdf 3 13 separator 0.9796945 ¶ 2368 2370 W2318910005.pdf 3 14 text 0.9996601 "In contrast, EM images of UROtsa cells incubated with liposomes encapsulating gold parti- cles at 37°C showed cluster of dark gold particles inside the cell and not outside the cell mem-brane ( Fig. 2A ). Corresponding higher magnification of the image showed that dark grains of gold were associated with vesicle like structures in an endosomal compartment (E) of UROtsa cells ( Fig. 2C ). Incubation of UROtsa cells with liposomes encapsulating gold particles at 4°C showed absence of dark grains inside the cell and only extracellular binding of liposomes con-taining dark grains of gold was seen ( Fig. 2B ). Corresponding higher magnification in Panel D showed that vesicle like structures were devoid of dark gold particles indicating absence of in- ternalization and the temperature dependence for the cellular uptake of encapsulated gold par-ticles. Since temperature had no effect on the internalization of gold particles ( Fig. 1 ), it can be inferred that liposomes as a carrier is necessary for the endocytosis to occur." 2370 3417 W2318910005.pdf 3 15 separator 0.99628294 ¶ 3417 3419 W2318910005.pdf 3 16 title 0.99069434 In vivo study 3419 3433 W2318910005.pdf 3 17 separator 0.9959624 ¶ 3433 3435 W2318910005.pdf 3 18 text 0.9997054 "Rat bladder was instilled with encapsulated liposome showed the uptake of gold across theurothelium ( Fig. 3A ); whereas the bladder instilled with plain gold showed the gold particles lying outside the tissue region of sections ( Fig. 3B ). The untreated bladder is shown as control" 3435 3721 W2318910005.pdf 3 19 separator 0.99339986 ¶ 3721 3723 W2318910005.pdf 3 20 title 0.88986063 Bladder Uptake of Liposomes by Endocytosis 3723 3766 W2318910005.pdf 3 21 separator 0.9305362 ¶ 3766 3768 W2318910005.pdf 3 22 paratext 0.9849895 PLOS ONE | DOI:10.1371/journal.pone.0122766 March 26, 2015 4/1 0 3768 3833 W2318910005.pdf 3 0 paratext 0.9683833 "Research Journal of Applied Sciences, Engineering a nd Technology 5(6): 223872244, 2013 DOI:10.19026/rjaset.5.4778 ISSN: 204077459; e7ISSN: 204077467 © 2013 Maxwell Scientific Publication Corp. Submitted: September 03, 2012 Accepted: September 24, 2012 Published: February 2 1, 2013" 0 316 W2186012262.pdf 0 1 separator 0.8906829 ¶ ¶ 318 324 W2186012262.pdf 0 2 contact 0.9931452 "Corresponding Author: Ling Mao, Department of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China" 324 480 W2186012262.pdf 0 3 separator 0.550625 481 482 W2186012262.pdf 0 4 paratext 0.95046955 "¶ This work is licensed under a Creative Commons Attr ibution 4.0 International License (URL: http://crea tivecommons.org/licenses/by/4.0/). 2238 Research Article" 482 652 W2186012262.pdf 0 5 separator 0.7262318 ¶ 654 656 W2186012262.pdf 0 6 title 0.9722205 Multiclass Image Segmentation Based on Pixel and Se gment Level 656 720 W2186012262.pdf 0 7 separator 0.89745283 ¶ ¶ 721 727 W2186012262.pdf 0 8 contact 0.9941019 "Ling Mao and Mei Xie Department of Electronic Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China" 727 876 W2186012262.pdf 0 9 separator 0.95974493 ¶ ¶ 877 883 W2186012262.pdf 0 10 text 0.99782276 "Abstract: Multi7class image segmentation (or pixel labeling) is one of the most important and challenging tasks in computer vision. Currently, many different methods for this task can be broadly categorized into two t ypes according to their choice of the partitioning of th e image space, i.e., pixels or segments. However, e ach choice of the two types of methods comes with its share of advant ages and disadvantages. In this study, we construct a novel CRF model to integrate features extracted from pixel an d segment levels. We exploit segments generated by Constrained Parametric Min Cuts (CPMC) algorithm in the propose d framework, instead of commonly used unsupervised segmentation method (e.g., mean7shift approach). Ad ditionally, the recognition based on these segments is also integrated into the model, which possible corrects classification mistakes caused by the unary term ba sed on information derived from pixel level. We experiment ally demonstrate our model’s quantitative and quali tative improvements over the baseline methods." 883 1964 W2186012262.pdf 0 11 separator 0.7179722 ¶ ¶ 1965 1971 W2186012262.pdf 0 12 text 0.4726347 Keywords: Constrained parametric min cuts, CRF, higher order potential, non 1971 2047 W2186012262.pdf 0 13 paratext 0.3007001 7 2047 2048 W2186012262.pdf 0 14 text 0.30201292 linear support vector 2048 2069 W2186012262.pdf 0 15 paratext 0.41601926 model 2069 2075 W2186012262.pdf 0 16 separator 0.9942101 ¶ ¶ 2077 2083 W2186012262.pdf 0 17 title 0.98923165 INTRODUCTION 2083 2096 W2186012262.pdf 0 18 separator 0.989186 ¶ ¶ 2097 2103 W2186012262.pdf 0 19 text 0.9995045 "As one of the most important and challenging tasks in computer vision, multi7class image segmentation (or pixel labeling) has received increasing attention i n recent years (He et al ., 2004; Shotton et al ., 2006; Gould et al ., 2008; Ladicky et al ., 2009). The PASCAL Visual Object Classes Challenge 2007 added object class based image segmentation as the taster competition, which has been propelling this trend. Here multi7class image segmentation aims to assign each pixel in an image with a class label from a predetermined set, e.g., plane, car, people, sheep." 2103 2702 W2186012262.pdf 0 20 separator 0.86147463 ¶ 2705 2707 W2186012262.pdf 0 21 text 0.99619734 "From the early 1990s, Markov Random Fields (MRFs) were exploited to address this problem of multi7class image segmentation (Bouman and Shapiro, 1994; Feng et al ., 2002; Kumar and Hebert, 2003a), since these undirected graphical models allowed one to incorporate local contextual constraints in the lab eling problems in a principled manner. However, the traditional MRF usually makes simplistic assumption s about the data, e.g., assuming the conditional independence of the observed data, which hinders capturing complex interactions in the observed data that might be required for classification purposes. Additionally MRF formulation often does not allow a ny use of data in label interactions." 2707 3448 W2186012262.pdf 0 22 separator 0.96659774 ¶ 3449 3451 W2186012262.pdf 0 23 text 0.9995552 "Kumar and Hebert (2003b) firstly applied Conditional Random Fields (CRFs) to segment man7 made structure from complex natural scenes. CRFs were proposed by Lafferty et al . (2001), which directly model the conditional distribution over labels give n the observations and take observed data into account in label interactions. Therefore, the method presented in Kumar and Hebert (2003a) performed better than thos e using MRFs in Kumar and Hebert (2003b). He et al . (2004) and Shotton et al. (2006) used CRFs for semantic segmentation problems with more object classes other than two." 3451 4068 W2186012262.pdf 0 24 separator 0.94858134 ¶ 4069 4071 W2186012262.pdf 0 25 text 0.9964379 "Turning to more recent times, many different methods have been proposed for multi7class pixel labeling, which can be broadly categorized into two types according to their choice of the partitioning of the image space. Some methods are formulated in terms o f pixels (Shotton et al ., 2006) and others used segments or groups of segments (Rabinovich et al ., 2007; Pantofaru et al ., 2008; Gould et al ., 2009). Each choice of the two types of methods comes with its share of advantages and disadvantages. Those pixel7based methods assign each pixel a label using features extracted from a regularly shaped patch around it o r at an offset from it Shotton et al . (2006). However, these small patches contain a limited amount of informati on. For example, they exclude useful shape7based cues o r robust statistics about the appearance of larger re gions. The former is very important in recognizing objects and the latter can help average out the random variatio ns of individual pixels. Although the segment7based (or region7based) methods can avoid the problem of pixe l7 based methods, usually these segments do not captur e" 4071 5262 W2186012262.pdf 0 0 paratext 0.9865377 RESEARCH ARTICLE Open Access 0 28 W2731947904.pdf 0 1 separator 0.8837796 ¶ 28 30 W2731947904.pdf 0 2 title 0.96763676 "High intensity of Tunga penetrans infection causing severe disease among pigs in Busoga, South Eastern Uganda" 30 144 W2731947904.pdf 0 3 separator 0.9781738 ¶ 144 146 W2731947904.pdf 0 4 contact 0.6829691 "Francis Mutebi1, Jürgen Krücken2*, Hermann Feldmeier3, Charles Waiswa1, Norbert Mencke4, Wilfred Eneku1 and Georg von Samson-Himmelstjerna2" 146 288 W2731947904.pdf 0 5 separator 0.99499774 ¶ 288 290 W2731947904.pdf 0 6 title 0.94857734 Abstract 290 299 W2731947904.pdf 0 7 separator 0.99434584 ¶ 299 301 W2731947904.pdf 0 8 text 0.9993277 "Background: Towards the improvement of stakeholders ’awareness of animal tungiasis, we report 10 unusual severe clinical cases of pig tungiasis which were associated with very high infection intensities of T. penetrans in an endemic area." 301 544 W2731947904.pdf 0 9 separator 0.78265595 ¶ 544 546 W2731947904.pdf 0 10 text 0.99965847 "Results: Morbidity of ten pigs with high sand flea intensities detected during high transmission seasons in an endemic area in Busoga sub region, Uganda is described in detail. The cases of pigs presented with a very high number of embedded sand fleas (median = 276, range = 141 –838). Acute manifestations due to severe tungiasis included ulcerations ( n= 10), abscess formation ( n= 6) and lameness ( n= 9). Chronic morphopathological presentations were overgrowth of claws ( n= 5), lateral deviation of dew claws ( n= 6), detachment ( n= 5) or loss of dew claws ( n= 1). Treatment of severe cases with a topical insecticidal aerosol containing chlorfenvinphos, dichlorvos and gentian violet resolved acute morbidity and facilitated healing by re-epithelialisation." 546 1326 W2731947904.pdf 0 11 separator 0.90283906 ¶ 1326 1328 W2731947904.pdf 0 12 text 0.9995845 "Conclusions: The presentations of tungiasis highlighted in this report show that high intensities of embedded T. penetrans can cause a severe clinical disease in pigs. Effective tungiasis preventive measures and early diagnosis for treatment could be crucial to minimize its effects on animal health." 1328 1633 W2731947904.pdf 0 13 separator 0.9950392 ¶ 1633 1635 W2731947904.pdf 0 14 paratext 0.5842121 Keywords: Tunga penetrans , Pigs, Severe, Tungiasis, Uganda 1635 1695 W2731947904.pdf 0 15 separator 0.99659574 ¶ 1695 1697 W2731947904.pdf 0 16 title 0.9315428 Background 1697 1708 W2731947904.pdf 0 17 separator 0.9934057 ¶ 1708 1710 W2731947904.pdf 0 18 text 0.9995465 "Tungiasis, a zoonotic parasitic dermatosis of humans and a wide range of domestic and wild mammals, is caused by the female penetrating sand flea, Tunga pene- trans . Currently, it is endemic in Latin America, the Caribbean and sub-Saharan Africa with a patchy distri- bution; mostly occurring in poor communities and often causing severe morbidity in both human and animals [1]. The disease is largely neglected in tropical human and veterinary medicine [2]. Pigs have been identified as the most important animal reservoirs of T. penetrans in sub-Saharan Africa. Frequently, they suffer from high parasite loads and severe morbidity [3, 4]. Most sand fleas localize on the coronary band and bulbs of thedigits [5 –7] but other body parts which contact or are close to the ground such as mammary glands, snout, legs, perineum and the tail may also be affected [1]." 1710 2604 W2731947904.pdf 0 19 separator 0.8986374 ¶ 2604 2606 W2731947904.pdf 0 20 text 0.9989419 "Proper and early diagnosis of tungiasis is essential for timely and appropriate treatment as well as con- trol in order to abate its effects on animal health." 2606 2769 W2731947904.pdf 0 21 separator 0.942986 ¶ 2769 2771 W2731947904.pdf 0 22 text 0.99928415 "Studies focusing on the clinical presentations of tun- giasis and its significance to animal wellbeing and health are very limited. Consequently, many animal health workers, at least in the highly endemic areas in Uganda, are not aware of the clinical significance of tungiasis and often consider it an insignificant nuisance which hardly requires veterinary medical care (Mutebi, unpublished findings). Hence, many cases go unattended despite detrimental effects on public and animal health. The accruing losses may hamper economic development of impoverished com- munities located in endemic areas." 2771 3394 W2731947904.pdf 0 23 contact 0.9908492 * Correspondence: Juergen.Kruecken@fu-berlin.de 3394 3441 W2731947904.pdf 0 24 separator 0.6054968 ¶ 3441 3443 W2731947904.pdf 0 25 contact 0.9910348 "2Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, 14163 Berlin, Germany" 3443 3555 W2731947904.pdf 0 26 separator 0.80921125 ¶ 3555 3557 W2731947904.pdf 0 27 paratext 0.94230646 "Full list of author information is available at the end of the article © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Mutebi et al. BMC Veterinary Research (2017) 13:206 DOI 10.1186/s12917-017-1127-z" 3557 4332 W2731947904.pdf 0 0 paratext 0.9228123 2 0 1 W3153057266.pdf 1 1 separator 0.99546814 ¶ 2 4 W3153057266.pdf 1 2 title 0.93378377 Abstract 5 14 W3153057266.pdf 1 3 separator 0.99608797 ¶ 15 17 W3153057266.pdf 1 4 text 0.9995046 "With th e advent of single-cell RNA sequ e ncing (scRNA-seq) technologies, th er e ha s been a spike in studies involving scRNA-seq of several tissues across diverse sp ecies including Drosophil a. Al though a few databases e xist for use rs to qu ery ge nes of inter est within t he scRNA-se q stu dies, search tools th at enable us ers to find or thologous gen es a nd their cell type-specific expr ession pa tt erns across species a re limited. H ere , we built a new sea rch dat a base, called DRscDB (https://www.flyrnai.org/tools/single_ce ll/web/) to address this need . DRscDB serves as a comprehensive r eposit ory for published scRNA-seq dat asets for Droso phil a and t he relevan t da tase ts from human and othe r model org anisms. DRscDB is based on manual curation of Drosophila scRN A-seq studies of various tissue types and th eir c orrespo nding analogous t issues in vert eb rates including zebrafish, mouse , and human . Of note , o ur search da tabas e provides most of th e litera tur e-derived marker genes, thus pres erving the o rigin al analysis of the published scR NA-seq da tase ts. DRscDB serves as a web-based user in terface tha t allow s users to mine, u tilize and comp are gen e expr ession da ta pert aining to scRN A-seq dat asets from th e published lit era tur e." 17 1348 W3153057266.pdf 1 5 separator 0.99717027 ¶ 1350 1352 W3153057266.pdf 1 6 title 0.9864666 1. Introduction 1352 1368 W3153057266.pdf 1 7 separator 0.9965941 ¶ 1370 1372 W3153057266.pdf 1 8 text 0.9996848 "Advances in scRNA-seq t echnologies h ave enabl ed a systems-level unde rstanding of several tissues at single-cell r esoluti on across div erse species , resul ting in the d evelopme nt of tissue and cell “atlases” [1-3]. Although a vast majority of scRNA-seq studies have b een p erform ed in samples from mammals such as mice and humans, a substanti al number of studi es in less complex model o rganisms have genera ted a n immense volume of new transcrip tomic data at th e single-cell l evel. For ins tance, in the five years tha t have followed the ava ilability of microfluidics-based scRNA-seq platform, more than 20 scRNA-seq studies of various o rgans from Drosophila, an d across a rang e of developmen tal time points and condi tions, have b een publish ed [4]. Similarly, several o ther s tudies on a wide variety of species across th e evolutio nary tr ee hav e been publish ed and scRN A-seq is quickly replacing the mor e tradi tional bulk R NA-seq base d tra nscript omics approach." 1372 2396 W3153057266.pdf 1 9 separator 0.97245145 ¶ 2398 2400 W3153057266.pdf 1 10 text 0.99966687 "The ‘big data’ thus gene rat ed from myriad scRNA-seq studi es has trem endous po t ential to aid in the devel opment of algor ithms, sea rch t ools, and re posito ries th at will benefi t th e advancemen t of basic resea rch. Whils t some dat abases docum ent and compile scR NA-seq stud ies in on e port al (see Supplemen tary Table 1 for e xamples), m ost have caveats that limi t thei r use for c ross-species analysis of multiple tissu es. These includ e search da tabases that focus on on e species or tissue and incorpo rat e weak or no ort holog gene se arch capabili ty. Furth ermor e, cer tain da tab ases re-an alyze published scRNA-seq dat a befor e consuming it. Al t hough re-analysis may not change th e tr anscriptomic architec tur e of cell clusters, i t may change the st ructur e of the scR NA-seq map an d the set of top- enriched mark er genes as compa red wit h the original analysis published by the a uthors . More over, search dat abases that fe atur e scRNA-seq datase ts from multiple speci es to facilita te a cross-species survey of a given gene tend to work well for orthol ogous genes th at have t he sam e name (or keyword) in different speci es but might not map o r thologs with differen t names. Altoge the r , ther e is a need for comprehensive da tabas es tha t allow use rs to search gen es of inter est acr oss various scRNA-seq dat ase ts obtain ed from different sp ecies and pr es erve the outcomes of th e original publish ed analyses." 2400 3900 W3153057266.pdf 1 11 paratext 0.9662396 . CC-BY 4.0 International license available under a(which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made The copyright holder for this preprint this version posted January 31, 2021. ; https://doi.org/10.1101/2021.01.29.428862doi: bioRxiv preprint 3901 4241 W3153057266.pdf 1 0 text 0.9986227 "lowest level, respectively, to compare with Imam Khomeini hospital. The similar form can be observed about the indoor thoron, although no signi ficant differences were detected ( P1⁄40.56)." 0 188 W2799595321.pdf 4 1 separator 0.9618778 ¶ 188 190 W2799595321.pdf 4 2 text 0.99946594 "The model indicated that the amount of radon in constructed buildings on soil with clayey gravel and sand feature, with a factor of 4.2 and a signi ficant difference, was more than those constructed on soil with clay texture and little pasty. On the other hand the coef ficient of thoron was minus (1.3) and a signi ficant difference was not observed. Generally with increased the soil porosity, the indoor radon and thoron concentrations increased 8.1 and 2.9 times, respectively." 190 677 W2799595321.pdf 4 3 separator 0.99704045 ¶ 677 679 W2799595321.pdf 4 4 title 0.9923006 2. Experimental design, materials and methods 679 725 W2799595321.pdf 4 5 separator 0.995395 ¶ 725 727 W2799595321.pdf 4 6 title 0.98461455 2.1. Description of study area 727 758 W2799595321.pdf 4 7 separator 0.9935819 ¶ 758 760 W2799595321.pdf 4 8 text 0.999438 "The radon and thoron concentrations were determined in three hospitals in Kermanshah, West part of Iran ( Fig. 2 ). Kermanshah is located in 34 °18′51′′N4 7 °03′54′′E with a cold semi-arid climate." 760 958 W2799595321.pdf 4 9 separator 0.62975925 ¶ 958 960 W2799595321.pdf 4 10 text 0.9995855 "The average temperature in summer and winter is 44.1 °C and −27°C, respectively, and the average annual temperature is 14.3 °C. The geological formation of the area mainly consists of radiolarites type sedimentary rows. It has upper Triassic to Cretaceous rocks including sediments from deep areas that among them sedimentary rows of radiolarites and carbonates along with ophiolite rocks were in the highest level [11]. Kermanshah sited in the high Zagros area which is surrounded by faults from north to south ( Fig. 3 )." 960 1494 W2799595321.pdf 4 11 title 0.90380263 Table 2 1494 1501 W2799595321.pdf 4 12 separator 0.98862284 ¶ 1501 1503 W2799595321.pdf 4 13 title 0.4737399 Multiple regression 1503 1523 W2799595321.pdf 4 14 caption 0.53687197 model determining 1523 1541 W2799595321.pdf 4 15 title 0.49535754 the in fluence of geological and meteorological 1541 1589 W2799595321.pdf 4 16 caption 0.41625574 parameters 1589 1599 W2799595321.pdf 4 17 title 0.5078194 "on indoor radon and thoron concentration." 1599 1643 W2799595321.pdf 4 18 separator 0.96354294 ¶ 1643 1645 W2799595321.pdf 4 19 table 0.98451436 "Variable On radon On thoron Coef. [%95Conf. Interval] Coef. [%95Conf. Interval] Geographical location Imam Khomeini (ra) 1 1Taleghani −2.4 [ −16.2 –11.4] -0.1 [ −4.1–4] Imam Reza (AS) 7.8 *[2–13.6] 4.3 [0 –8.7] Soil type clay with a little pasty 1 1clayey gravel with sand 4.2 *[1 - 7.36] 1.3 [ −1.4 - 4] Soil porosity 8.1 [ −2.1–18.2] 2.9 [ −5.3–11.1] Indoor temprature 19 [ −183.5 –221.5] 44.2 *[30.3 –58] Outdoor temprature −17.2 [ −220.4 –186] −45.2 *[ −59.1 –−31.4] Indoor-Outdoor temperature differential −17.7 −223–187.6] −44.5 *[ −58.6 –-30.5] Indoor humidity −0.4 [ −7.3–6.6] −1.5 *[ −1.9–-1] Outdoor humidity 0.2 [ −5–5.4] 0.5 *[0.2 –0.9] Indoor pressure 0.5 [ −11.1–12] 0.5 [ −0.3–1.3] Outdoor pressure −0.6 [ −16–14.7] −1.9 *[ −2–-0.8] Windspeed −0.7 [ −3.3–1.8] −1* [ −1.1–-0.8] Rainfall −0.9 [ −3.3–1.4] −0.2 *[ −0.3–-0.02] *Statistically signi ficant." 1645 2549 W2799595321.pdf 4 20 title 0.7958644 Table 1 2549 2556 W2799595321.pdf 4 21 separator 0.7041549 ¶ 2556 2558 W2799595321.pdf 4 22 table 0.98514605 "Average concentration of radon and thoron. Hospital Radon level (Bq/m3) Thoron level (Bq/m3) Imam Khomeini (ra) 6.8 74.4 2.8 72.8 Taleghani 11.6 73.9 3.8 72.75 Imam Reza (AS) 13.7 74.3 4.64 74.84M." 2558 2764 W2799595321.pdf 4 23 paratext 0.9307025 Pirsaheb et al. / Data in Brief 18 (2018) 1945 –1951 1949 2764 2822 W2799595321.pdf 4 0 paratext 0.95559746 "¶ 741 ¶ J.Th i-Qar Sci. Vol.5 (3) Dec./201 5" 1 108 W4240297474.pdf 3 1 separator 0.9095687 ¶ ¶ 109 115 W4240297474.pdf 3 2 text 0.9879766 "N719 and aggregation of N719 to ZnO NW surface introduce no change in crystalline structure of ZnO NW." 115 224 W4240297474.pdf 3 3 separator 0.9960765 ¶ 226 228 W4240297474.pdf 3 4 title 0.9922951 2- Current density -Voltage Characteristic 228 271 W4240297474.pdf 3 5 separator 0.9936954 ¶ 273 275 W4240297474.pdf 3 6 text 0.9977281 "Based on P3HT and P3HT mix 5% wt graphene for ZnO nanorod modified N719 as a working electrode explained in the figure 5 where the pristine P3HT, P3HT -G as HTM, as seen from the figures of I -V characteristic that P3HT -graphene better performance than pristine P3HT, due to graphene used to enrichment of P3HT and that will help decrease the internal resistivity. Furthermore, the performance of solar cells at 0.1 M Iodine represent best PCE as we see from the Table 1,and Figure 6 the best efficiencies for the optimum condition which are 0.1 M Iodine and P3HT - Graphe ne with ZnO nanorods modified N719 represent most efficient solid -state dye sensitive solar cells." 281 992 W4240297474.pdf 3 7 separator 0.9878562 ¶ 993 995 W4240297474.pdf 3 8 caption 0.8753944 "Figures 4 , 5,and 6 display I -V characteristic of the photovoltaic devices." 995 1075 W4240297474.pdf 3 9 separator 0.99707067 ¶ 1077 1079 W4240297474.pdf 3 10 title 0.9913706 4. Conclusions 1079 1094 W4240297474.pdf 3 11 separator 0.99661064 ¶ 1097 1099 W4240297474.pdf 3 12 text 0.9972299 "Recently, graphene , a single layer hexagonal lattice of carbon nanotube atoms, has recently emerged with conductive polymer for improving properties because graphene possesses a range of unusual properties therefore the efficiency increase for both designs when loading 5% w t graphene with P3HT as counter electrode (HTM), Table 1 shown increasing in efficiency and the efficiency for ZnO nanorod, as a working electrodes The better performance of solar cells with 0.1 M iodine as a solid electrolyte and P3HT - Graphene as HTM in s olid-state dye sensitive solar cells less performance than pristine P3HT because P3HT -graphene provide an intrinsic energy barrier which effectively suppresses charges recombination and increases the electron life time. In addition the Iodine has high elec trons provider to less electron lifetime." 1099 1981 W4240297474.pdf 3 13 separator 0.99727 ¶ 1983 1985 W4240297474.pdf 3 14 title 0.9874811 Acknowledgments 1985 2001 W4240297474.pdf 3 15 separator 0.99559474 ¶ 2003 2005 W4240297474.pdf 3 16 text 0.99566483 "We thank the Ministry of Higher Education and Scientific Research of Iraq for its support of scientific researches through the Iraqi Virtual Science Library (IVSL)." 2005 2179 W4240297474.pdf 3 17 separator 0.67930883 "¶ " 2182 2192 W4240297474.pdf 3 18 paratext 0.325148 ¶ 2192 2196 W4240297474.pdf 3 19 math 0.3779261 ¶ 2196 2197 W4240297474.pdf 3 20 paratext 0.31636798 2199 2200 W4240297474.pdf 3 21 math 0.41198197 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 2200 2349 W4240297474.pdf 3 22 separator 0.7725299 "¶ ¶" 2351 2361 W4240297474.pdf 3 23 caption 0.99588233 Figure 1: SEM images of ZnO nanorods. 2361 2399 W4240297474.pdf 3 24 separator 0.68001556 ¶ ¶ 2401 2407 W4240297474.pdf 3 25 caption 0.9955236 "Figure 2: The optical absorption spectrum of the poly (3HT 5% wt) in the UV -visible -NIR range." 2407 2507 W4240297474.pdf 3 26 separator 0.8631933 ¶ ¶ 2509 2515 W4240297474.pdf 3 27 caption 0.99606425 "Figure 3: The Optical Absorption spectrum of ZnO NW, ZnO NW/N719, and N719 solution." 2515 2603 W4240297474.pdf 3 28 separator 0.7368446 ¶ ¶ 2605 2611 W4240297474.pdf 3 29 caption 0.9964851 "Figure 4: XRD spectrum of pristine N719 (red curve), N719 on ZnO NW arrays (black curve), and ITO (yellow)." 2611 2725 W4240297474.pdf 3 30 separator 0.7597592 ¶ ¶ 2726 2732 W4240297474.pdf 3 31 caption 0.99664766 "Figure 5: Current density vs. voltage measured on P3HT/ZnO nanowire arrays solid state dye for Pristine." 2732 2840 W4240297474.pdf 3 32 separator 0.99596524 ¶ 2842 2844 W4240297474.pdf 3 0 paratext 0.96454304 "Rasha Ali Mohammad, Ahmad Al Manadili. The Diagnostic Role of P16ink4a in Detecting High-Risk HPV16 in a Group of Syrian Nasopharyngeal Carcinoma Patients. Int J Dentistry Oral Sci. 2021;8(1):1302-1307.1304 OPEN ACCESS https://scidoc .org/IJDOS.php" 0 427 W3134707686.pdf 2 1 separator 0.9945668 ¶ 427 429 W3134707686.pdf 2 2 caption 0.49992964 density score by intensity one [17-19] . 429 470 W3134707686.pdf 2 3 separator 0.9867189 ¶ 470 472 W3134707686.pdf 2 4 text 0.984099 "We can notice the pale nucleus staining and strong staining very obviously of HPVhr16 in (Figure 1), and the obvious brown staining of nucleus in basal layers only, (Figure 2). which both show the different expression appearance of HPVhr16 in immu-nohistochemical staining. Whereas staining of P16ink4a is seen either in the whole epithe - lium adjacent to NPC lesion, (Figure 3).Relation " 472 873 W3134707686.pdf 2 5 title 0.49192426 between 873 880 W3134707686.pdf 2 6 text 0.7726293 HPVhr16 expression and P16ink4a stain - 880 920 W3134707686.pdf 2 7 separator 0.95460206 ¶ 920 923 W3134707686.pdf 2 8 text 0.9941455 "ingWhen we compared the percentage of positive expression of HPV and P16ink4a, we found that 50% of NPC patients who had positive expression of HPVhr 16, expressed positivity of P16ink4a, but patients who didn’t express positivity of the virus, had positive expression of P16ink4a in 50% of cases also." 923 1236 W3134707686.pdf 2 9 separator 0.6954285 ¶ 1236 1238 W3134707686.pdf 2 10 text 0.9977617 "Only 9.9% of NPC patients who have the infection of HPVhr 16 expressed negative expression of P16ink4a, which means that expression of p16 didn’t give the purpose it was used for in these limitedcases, whereas 90.1% of NPC patients included in this study showed negative expression of both P16ink4a and HPV (Table 2)." 1238 1565 W3134707686.pdf 2 11 separator 0.9966181 ¶ 1565 1567 W3134707686.pdf 2 12 title 0.98080003 Discussion 1567 1578 W3134707686.pdf 2 13 separator 0.9940585 ¶ 1578 1580 W3134707686.pdf 2 14 title 0.6888405 HPVHR 16 Expression in nasopharyngeal carcinoma 1580 1628 W3134707686.pdf 2 15 separator 0.9021778 ¶ 1628 1630 W3134707686.pdf 2 16 text 0.99567246 Since HPVhuman papilloma virus is involved in the etiology of 1630 1692 W3134707686.pdf 2 17 separator 0.980129 ¶ 1694 1696 W3134707686.pdf 2 18 title 0.81310374 Table 1. Expression of P16ink4a detected in 89 patients of NPC. 1696 1762 W3134707686.pdf 2 19 separator 0.98488736 ¶ 1762 1764 W3134707686.pdf 2 20 table 0.9811537 "Percentage Frequency Expression 9.0% 8 High 6.7% 6 Low 84.30% 75 Non " 1764 1840 W3134707686.pdf 2 21 separator 0.57976085 ¶ 1840 1841 W3134707686.pdf 2 22 table 0.69984806 Table 2. HPV expression *P16ink4a expression in 89 patients of NPC ur. 1841 1913 W3134707686.pdf 2 23 separator 0.7741172 ¶ 1913 1915 W3134707686.pdf 2 24 table 0.9907756 "P16ink4a Positive expression (high /low)Negative expression (no expression) expressionHPV HPV+ HPV- HPV+ HPV- frequency 4 4 8 73 percentage 50% 50% 9.90% 90.10%" 1915 2087 W3134707686.pdf 2 25 separator 0.9706013 ¶ 2087 2089 W3134707686.pdf 2 26 caption 0.99638504 Figure 1. The localized staining of HPVhr16 antibody in the epithelium of NPC section, magnification ×40. 2089 2197 W3134707686.pdf 2 27 separator 0.9773289 ¶ 2197 2199 W3134707686.pdf 2 28 caption 0.99411505 "Figure 2. Immunohistochemical Staining of HPVhr16, we can notice the nucleus staining is only obvious in the basal layers of epithelium peripheral to NPC lesion. Magnification ×10." 2199 2385 W3134707686.pdf 2 29 separator 0.9942633 ¶ 2385 2387 W3134707686.pdf 2 0 paratext 0.82035184 i 0 1 W2971462308.pdf 0 1 separator 0.9533678 ¶ ¶ 2 8 W2971462308.pdf 0 2 title 0.8410935 Appendix 3. Forest plots of continuous outcomes presented in Table 3 of manuscript . 9 97 W2971462308.pdf 0 3 separator 0.9915893 ¶ 98 100 W2971462308.pdf 0 4 text 0.8111242 "Supplementary figure numbers correspond to the page number of appendix in which they can be found ." 100 205 W2971462308.pdf 0 5 separator 0.995037 ¶ 207 209 W2971462308.pdf 0 6 title 0.975365 Blood loss during delivery/operation 209 246 W2971462308.pdf 0 7 separator 0.993225 ¶ 248 250 W2971462308.pdf 0 8 caption 0.9608914 "Supplementary Figure 1. Forest plot of studies comparing carbetocin with any other uterotonic regimen for the operative blood loss with cesarean deliver y." 250 413 W2971462308.pdf 0 9 separator 0.9703119 ¶ 415 417 W2971462308.pdf 0 10 caption 0.70076585 "Supplementary Figure 2. Forest plot of studies comparing carb etocin with any oxytocin regimen for the operative" 417 536 W2971462308.pdf 0 11 text 0.4551952 blood 536 542 W2971462308.pdf 0 12 caption 0.5140153 loss with 542 553 W2971462308.pdf 0 13 text 0.4920927 cesarean delivery 553 571 W2971462308.pdf 0 14 caption 0.45294967 571 572 W2971462308.pdf 0 15 text 0.89704967 ". Studies using different oxytocin regimens (intravenous push, infusion or combination) were combined together." 572 686 W2971462308.pdf 0 16 separator 0.9869989 ¶ 688 690 W2971462308.pdf 0 17 caption 0.9234071 "Supplementary Figure 3. Forest plot of studies comparing carbetocin with oxytocin infusion regimens for the operative blood loss with cesarean delivery . Studies" 690 859 W2971462308.pdf 0 18 text 0.52386624 "using intravenous infusion regimens" 859 898 W2971462308.pdf 0 19 caption 0.49277863 of 898 901 W2971462308.pdf 0 20 text 0.69987035 oxytocin (with or without initial intravenous push) were combined together 901 976 W2971462308.pdf 0 21 caption 0.5262809 . 976 977 W2971462308.pdf 0 22 separator 0.98776054 ¶ 979 981 W2971462308.pdf 0 23 caption 0.86821246 "Supplementary Figure 4. Forest plot of studies comparing carbetocin with standard oxytocin regimens for the operative blood loss with cesarean delivery . Studies using standard oxytocin regimens (" 981 1188 W2971462308.pdf 0 24 text 0.51730293 intravenous 1188 1199 W2971462308.pdf 0 25 caption 0.5489762 push or 1199 1207 W2971462308.pdf 0 26 text 0.4772367 intramuscular 1207 1221 W2971462308.pdf 0 27 caption 0.70992565 injection) were combined together. 1221 1256 W2971462308.pdf 0 28 separator 0.9902003 ¶ 1258 1260 W2971462308.pdf 0 29 caption 0.9831324 "Supplementary Figure 5. Forest plot of studies comparing carbetocin with any other uterotonic regimen for the blood loss with vaginal delivery ." 1260 1411 W2971462308.pdf 0 30 separator 0.9665078 ¶ 1412 1414 W2971462308.pdf 0 31 caption 0.98620844 "Supplementary Figure 6. Forest plot of studies comparing carbetocin with syntometrine for the blood loss with vaginal delive ry." 1414 1550 W2971462308.pdf 0 32 separator 0.96092135 ¶ 1551 1553 W2971462308.pdf 0 33 caption 0.9870157 "Supplementary Figure 7. Forest plot of studies comparing carbetocin with any oxytocin regimen for the blood loss with vaginal delivery ." 1553 1697 W2971462308.pdf 0 34 separator 0.99084264 ¶ ¶ 1698 1704 W2971462308.pdf 0 35 title 0.94725317 Hemoglobin drop after delivery 1704 1735 W2971462308.pdf 0 36 separator 0.98997486 ¶ 1737 1739 W2971462308.pdf 0 37 caption 0.98849726 "Supplementary Figure 8 . Forest plot of studies comparing carbetocin with any other uterotonic for the hemoglobin drop with cesarean delivery ." 1739 1888 W2971462308.pdf 0 38 separator 0.93590677 ¶ 1890 1892 W2971462308.pdf 0 39 caption 0.99223065 "Supplementary Figure 9 . Forest plot of studies comparing carbetocin with any oxytocin regimen for the hemoglobin drop with cesarean delivery ." 1892 2041 W2971462308.pdf 0 40 separator 0.9351573 ¶ 2043 2045 W2971462308.pdf 0 41 caption 0.99435157 "Supplementary Figure 10 . Forest plot of studies comparing carbetocin with oxytocin infusion regimens for the hemoglobin drop with cesarean delivery ." 2045 2200 W2971462308.pdf 0 42 separator 0.90174675 ¶ 2201 2203 W2971462308.pdf 0 43 caption 0.99441075 "Supplementary Figure 11 . Forest plot of studies comparing carbetocin with standard oxytocin regimens for the hemoglobin drop with cesarean delivery ." 2203 2359 W2971462308.pdf 0 44 separator 0.90483356 ¶ 2360 2362 W2971462308.pdf 0 45 caption 0.99338925 "Supplementary Figure 12 . Forest plot of studies comparing carbetocin with any other uterotonic for the hemoglobin drop with vaginal delivery ." 2362 2511 W2971462308.pdf 0 46 separator 0.9082463 ¶ 2512 2514 W2971462308.pdf 0 47 caption 0.9932095 "Supplementary Figure 13 . Forest plot of studies comparing carbetocin with syntometrine for the hemoglobin drop with vaginal delivery ." 2514 2656 W2971462308.pdf 0 48 separator 0.9348286 ¶ 2657 2659 W2971462308.pdf 0 49 caption 0.9938314 "Supplementary Figure 14 . Forest plot of studies comparing carbetocin with any oxytocin regimen for the hemoglobin drop with vaginal deliver" 2659 2805 W2971462308.pdf 0 0 bibliography 0.9969286 "33. Wan Y, Xu J, Ma D, Zeng Y, Cibelli M, et al. (2007) Postoperative impairment of cognitive function in rats: a possible role for cytokine-mediated inflammation in the hippocampus. Anesthesiology 106: 436–43." 0 214 W2103605221.pdf 8 1 separator 0.9890318 ¶ 214 216 W2103605221.pdf 8 2 bibliography 0.9969568 "34. Myles PS, Daly D, Silvers A, Cairo S (2009) Prediction of neurological outcome using bispectral index monitoring in patients with severe ischemic-hypoxic brain injury undergoing emergency surgery. Anesthesiology 110: 1106–1115.35. Terrando N, Monaco C, Ma D, Foxwell BM, Feldmann M, et al. (2010) Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitivedecline. Proc Natl Acad Sci U S A 107: 20518–22.RCT of Optimised Anaesthesia to Reduce POCD" 216 703 W2103605221.pdf 8 3 separator 0.99072397 ¶ 703 705 W2103605221.pdf 8 4 paratext 0.97549653 PLoS ONE | www.plosone.org 9 June 2012 | Volume 7 | Issue 6 | e37410 705 774 W2103605221.pdf 8 0 paratext 0.9665209 SPATIAL AND TEMPORAL CORRELATIONS IN NEURAL ... PHYSICAL REVIEW RESEARCH 5, 013005 (2023) 0 87 W4313640004.pdf 22 1 separator 0.98225474 ¶ 87 89 W4313640004.pdf 22 2 text 0.9486391 "where P({σ},t+τ|{S},t) is conditional probability of finding the system in configuration {σ}at time t+τ, given that it was in configuration {S}at time t. Since the conditional probability obeys the same master equation, we have ¶" 89 318 W4313640004.pdf 22 3 math 0.9445699 "d dτ/angbracketleftSi(t)Sj(t+τ)/angbracketright=/angbracketleft Si(t)(1−2Sj(t+τ))w(Sj(t+τ))/angbracketright. (B7)" 318 434 W4313640004.pdf 22 4 separator 0.8965633 ¶ 434 436 W4313640004.pdf 22 5 text 0.98377156 "Substituting the explicit form of the transition rates and summing over all configurations, we get the following coupled equations for the first moment [ 36–40]:" 436 598 W4313640004.pdf 22 6 separator 0.5932506 ¶ 598 600 W4313640004.pdf 22 7 math 0.9579361 "d dt/angbracketleftSi/angbracketright(t)=α1−(α1+α2)/angbracketleftSi/angbracketright+β1/angbracketleftBigg/summationdisplay l;l→iSl/angbracketrightBigg +(β2−β1)/angbracketleftBigg Si/summationdisplay l;l→iSl/angbracketrightBigg . (B8)" 600 847 W4313640004.pdf 22 8 separator 0.7955648 ¶ 847 849 W4313640004.pdf 22 9 text 0.927972 "Here,/summationtext l;l→iSldenotes the sum of states of units directly connected to unit i. Subtracting the mean δSi=Si−/angbracketleftSi/angbracketright, we find the time-evolution equation for equal-time correlation as " 849 1074 W4313640004.pdf 22 10 separator 0.4979439 ¶ 1074 1075 W4313640004.pdf 22 11 math 0.9494254 "d dt/angbracketleftδSi(t)δSj(t)/angbracketright=− 2(α1+α2)/angbracketleftδSiδSj/angbracketright+β1⎛ ⎝/angbracketleftBigg/summationdisplay l;l→iδSl·δSj/angbracketrightBigg +/angbracketleftBigg δSi/summationdisplay l;l→jδSl/angbracketrightBigg⎞ ⎠ +(β2−β1)⎛ ⎝/angbracketleftBigg δSi/summationdisplay l;l→iδSlδSj/angbracketright+/angbracketleftδSiδSj/summationdisplay l;l→jδSl/angbracketrightBigg⎞ ⎠, here i/negationslash=j. (B9)" 1075 1527 W4313640004.pdf 22 12 separator 0.96944773 ¶ 1527 1529 W4313640004.pdf 22 13 text 0.9821437 "Substituting the explicit form of transition rates into the time-evolution of time-delayed quadratic moment, we find the time- evolution equation for autocorrelation" 1529 1696 W4313640004.pdf 22 14 separator 0.78641605 ¶ 1696 1698 W4313640004.pdf 22 15 math 0.9534099 "d dτ/angbracketleftδSi(t)δSi(t+τ)/angbracketright=− (α1+α2)/angbracketleftBigg δSi(t)δSi(t+τ)/angbracketright+β1/angbracketleftδSi(t)/summationdisplay l;l→iδSl(t+τ)/angbracketrightBigg +(β2−β1)⎛ ⎝/angbracketleftBigg δSi(t)δSi(t+τ)/summationdisplay l;l→iδSl(t+τ)/angbracketrightBigg⎞ ⎠ (B10)" 1698 2005 W4313640004.pdf 22 16 separator 0.67829186 ¶ 2005 2007 W4313640004.pdf 22 17 math 0.65582925 and 2007 2011 W4313640004.pdf 22 18 text 0.70111024 the time-evolution 2011 2030 W4313640004.pdf 22 19 math 0.51925784 2030 2031 W4313640004.pdf 22 20 text 0.6831282 equation for the time-delayed cross-correlation 2031 2078 W4313640004.pdf 22 21 separator 0.3554344 2078 2079 W4313640004.pdf 22 22 math 0.9420086 "¶ d dτ/angbracketleftδSi(t)δSj(t+τ)/angbracketright=− (α1+α2)/angbracketleftδSi(t)δSj(t+τ)/angbracketright+β1/angbracketleftBigg δSi(t)/summationdisplay l;l→jδSl(t+τ)/angbracketrightBigg +(β2−β1)⎛ ⎝/angbracketleftBigg δSi(t)δSj(t+τ)/summationdisplay l;l→jδSl(t+τ)/angbracketrightBigg⎞ ⎠, here i/negationslash=j. (B11)" 2079 2412 W4313640004.pdf 22 23 separator 0.9953253 ¶ 2412 2414 W4313640004.pdf 22 24 title 0.99339134 APPENDIX C: TIME EVOLUTION OF A VERAGED CORRELATION FUNCTIONS IN TWO-DIMENSIONAL MODEL 2414 2501 W4313640004.pdf 22 25 separator 0.9950276 ¶ 2501 2503 W4313640004.pdf 22 26 text 0.9944544 "For the two-dimensional models with nearest-neighbor connectivity, the steady state equation for equal-time cross-correlation function is given by" 2503 2652 W4313640004.pdf 22 27 separator 0.7068219 ¶ 2652 2654 W4313640004.pdf 22 28 math 0.7998247 C2(x1,x2)=β1 2654 2667 W4313640004.pdf 22 29 separator 0.5151769 ¶ 2667 2669 W4313640004.pdf 22 30 math 0.9507383 "α1+α2[C2(x1−a,x2)+C2(x1+a,x2)+C2(x1,x2+a)+C2(x1,x2−a)+C2(x1+a,x2+a) +C2(x1+a,x2−a)+C2(x1−a,x2+a)+C2(x1−a,x2−a)+(δx1,0δx2,a+δx1,0δx2,−a+δx1,−aδx2,0 +δx1,aδx2,0+δx1,aδx2,a+δx1,aδx2,−a+δx1,−aδx2,a+δx1,−aδx2,−a)A(0)]. (C1)" 2669 2892 W4313640004.pdf 22 31 separator 0.5325617 ¶ 2892 2894 W4313640004.pdf 22 32 text 0.8719632 The time-evolution equation for the time-delayed cross-correlation function is 2894 2974 W4313640004.pdf 22 33 separator 0.44091913 ¶ 2974 2975 W4313640004.pdf 22 34 math 0.94734365 "τ0d dtC2(x1,x2,t)=−C2(x1,x2,t)+β1 α1+α2[C2(x1−a,x2,t)+C2(x1,x2−a,t)+C2(x1+a,x2,t)+C2(x1,x2+a,t) +C2(x1+a,x2+a,t)+C2(x1+a,x2−a,t)+C2(x1−a,x2+a,t)+C2(x1−a,x2−a,t) +(δx1,0δx2,a+δx1,0δx2,−a+δx1,−aδx2,0+δx1,aδx2,0+δx1,aδx2,a+δx1,aδx2,−a+δx1,−aδx2,a+δx1,−aδx2,−a)A2(t)]. (C2)" 2975 3255 W4313640004.pdf 22 35 separator 0.61002934 ¶ 3255 3257 W4313640004.pdf 22 36 text 0.85298556 The time-evolution equation for the average autocorrelation function is 3257 3330 W4313640004.pdf 22 37 separator 0.42212787 ¶ 3330 3331 W4313640004.pdf 22 38 math 0.94205385 "τ0d dtA2(t)=−A2(t)+β1 α1+α2[4C2(a,a,t)+2C2(a,0,t)+2C2(0,a,t)]. (C3)" 3331 3403 W4313640004.pdf 22 39 separator 0.925959 ¶ 3403 3405 W4313640004.pdf 22 40 paratext 0.94396496 013005-23 3405 3415 W4313640004.pdf 22 0 paratext 0.9902138 Pharmacy 2021 ,9, 196 6 of 9 0 28 W4200100058.pdf 5 1 separator 0.9860542 ¶ 28 30 W4200100058.pdf 5 2 title 0.9898435 3.2. Economic Impact 30 51 W4200100058.pdf 5 3 separator 0.99340266 ¶ 51 53 W4200100058.pdf 5 4 title 0.98757535 3.2.1. Cost Avoidance 53 75 W4200100058.pdf 5 5 separator 0.9950582 ¶ 75 77 W4200100058.pdf 5 6 text 0.99895865 "The potential cost avoidance per month resulting from all the interventions made by the palliative care pharmacy team was GBP 61,824 (see Table 6). When adjusted to include the cost avoidance from only those patients who were not at the end of life (33%; Table 3), the estimated cost avoidance was GBP 20,402/month." 77 399 W4200100058.pdf 5 7 separator 0.9970975 ¶ 399 401 W4200100058.pdf 5 8 title 0.8995573 Table 6. Estimated ScHARR cost avoidance each month for interventions by palliative care pharmacy service. 401 508 W4200100058.pdf 5 9 separator 0.98693776 ¶ 508 510 W4200100058.pdf 5 10 table 0.9911351 "Eadon GradeMean Number of Interventions per Month per GradeScHARR Cost Avoidance (Taken as Mid-Point of Range, GBP)Total Estimated Cost Avoidance per Month per Grade (GBP) 3 65.4 3 196 4 348.8 108 37,670 5 21.8 1099 23,958 Total Estimated Cost Avoidance GBP 61,824/month Total Estimated Cost Avoidance Adjusted for Patients notat end of life (i.e., 33%) GBP 20,402/month" 510 901 W4200100058.pdf 5 11 separator 0.9947378 ¶ 901 903 W4200100058.pdf 5 12 text 0.9984533 "The potential future cost avoidance resulting from one full-time palliative care phar- macist was then estimated (see Table 7). The findings indicated that one pharmacist could review 45 patients per month. The data collected found a mean of 6.8 interventions per month. To prevent over estimation, this was rounded down to six interventions per month." 903 1261 W4200100058.pdf 5 13 separator 0.6709635 ¶ 1261 1263 W4200100058.pdf 5 14 text 0.99882346 "The potential cost avoidance per month for one full-time equivalent pharmacist was esti- mated to be GBP 38,287, and following adjustment for those patients not at the end of life (33%), the cost avoidance was GBP 12,635/month." 1263 1495 W4200100058.pdf 5 15 separator 0.99702615 ¶ 1495 1497 W4200100058.pdf 5 16 title 0.90661067 "Table 7. Prediction of potential ScHARR cost avoidance associated with palliative care pharmacist interventions for one full-time equivalent pharmacist." 1497 1652 W4200100058.pdf 5 17 separator 0.86341 ¶ 1652 1654 W4200100058.pdf 5 18 table 0.95575 "Anticipated Mean no. Patients per Month = 45 (for 1 Full-Time Equivalent Pharmacist) Estimated No. Interventions/Patient = 6.8 (Rounded Down to Nearest Whole Number = 6)" 1654 1826 W4200100058.pdf 5 19 separator 0.7873311 ¶ 1826 1828 W4200100058.pdf 5 20 table 0.99164635 "Eadon Grade% of Total Interventions/MonthAnticipated Number of Interventions per MonthScHARR Cost Avoidance (Taken as Mid-Point of Range, GBP)Total Potential Cost Avoidance (GBP) 3 15 40.5 3 122 4 80 216 108 23,328 5 5 13.5 1099 14,837 Total Potential Cost Avoidance GBP 38,287/month Total Potential Cost Avoidance Adjusted for Patients notat end of life (i.e.,33%) GBP 12,635/month" 1828 2235 W4200100058.pdf 5 21 separator 0.996027 ¶ 2235 2237 W4200100058.pdf 5 22 title 0.99006796 3.2.2. Length of Stay 2237 2259 W4200100058.pdf 5 23 separator 0.996168 ¶ 2259 2261 W4200100058.pdf 5 24 text 0.99809885 "There were 78 patients reviewed by the pharmacy service between June and July. Twenty-five percent of these patients ( n= 20) had their length of stay in the hospital documented. One hundred and nineteen palliative patients were not reviewed by the pharmacy service, but were in hospital during the same time period. Twenty-five percent of these patients ( n= 30) had their length of stay in the hospital documented. The data illustrated in Table 8 indicate that those palliative care patients who were reviewed by a palliative care pharmacist had a shorter length of stay compared with those patients with no palliative care pharmacist involvement (8.75 days versus 10 days). The difference was greater for those patients who were discharged from hospital (7.9 days versus 11.8 days)." 2261 3061 W4200100058.pdf 5 0 paratext 0.9908502 Page 15/16 0 10 W4385717868.pdf 14 1 separator 0.99513113 ¶ 10 12 W4385717868.pdf 14 2 caption 0.95276284 Figure 2 12 21 W4385717868.pdf 14 3 separator 0.90374887 ¶ 21 23 W4385717868.pdf 14 4 caption 0.98843396 Optimal cut-off and comparison of univariate ROC curve analysis. 23 88 W4385717868.pdf 14 5 separator 0.9808853 ¶ 88 90 W4385717868.pdf 14 6 caption 0.81972224 Abbreviations: AUC, area under the curve; ROC, receiver operating characteristic. 90 172 W4385717868.pdf 14 7 separator 0.99417055 ¶ 172 174 W4385717868.pdf 14 8 title 0.7192829 A. Receiver operating characteristics (ROC) analysis for anti- β 2GP 174 243 W4385717868.pdf 14 0 paratext 0.53368044 To 0 2 W4293262509.pdf 0 1 title 0.51065177 ward 2 6 W4293262509.pdf 0 2 paratext 0.5655157 6 7 W4293262509.pdf 0 3 title 0.56882006 a Risk Assessment Model 7 30 W4293262509.pdf 0 4 paratext 0.5879728 30 31 W4293262509.pdf 0 5 title 0.54255944 Based on Multi-Agent System for Cloud 31 68 W4293262509.pdf 0 6 paratext 0.5685006 ¶ Consumer 68 79 W4293262509.pdf 0 7 separator 0.98200005 ¶ 79 81 W4293262509.pdf 0 8 contact 0.7203178 Authors : Saadia Drissi 81 105 W4293262509.pdf 0 9 separator 0.99372315 ¶ 105 107 W4293262509.pdf 0 10 text 0.9974285 "Abstract : The cloud computing is an innovative paradigm that introduces several changes in technology that have resulted a new ways for cloud providers to deliver their services to cloud consumers mainly in term of security risk assessment, thus, adapting a current risk assessment tools to cloud computing is a very difficult task due to its several characteristics that challenge the effectiveness of risk assessment approaches. As consequence, there is a need of risk assessment model adapted to cloud computing. This paper requires a new risk assessment model based on multi-agent system and AHP model as fundamental steps towards the development of flexible risk assessment approach regarding cloud consumers." 107 833 W4293262509.pdf 0 11 separator 0.98899764 ¶ 833 835 W4293262509.pdf 0 12 text 0.4557001 Keywords : cloud computing, risk assessment model, multi-agent system, AHP model, cloud 835 923 W4293262509.pdf 0 13 paratext 0.30972043 consumer 923 932 W4293262509.pdf 0 14 separator 0.99555576 ¶ 932 934 W4293262509.pdf 0 15 paratext 0.5175204 Conference 934 945 W4293262509.pdf 0 16 title 0.6132869 Title 945 951 W4293262509.pdf 0 17 paratext 0.53777444 951 952 W4293262509.pdf 0 18 title 0.50841194 : 952 953 W4293262509.pdf 0 19 paratext 0.5605532 ICCETA 2014 : 953 967 W4293262509.pdf 0 20 title 0.5349976 International Conference on Cloud Engineering 967 1013 W4293262509.pdf 0 21 paratext 0.46781328 : 1013 1014 W4293262509.pdf 0 22 title 0.5013966 Theory and Applications 1014 1038 W4293262509.pdf 0 23 separator 0.9612925 ¶ 1038 1040 W4293262509.pdf 0 24 paratext 0.5792799 Conference Location : Paris, France 1040 1076 W4293262509.pdf 0 25 separator 0.77881515 ¶ 1076 1078 W4293262509.pdf 0 26 paratext 0.6323852 Conference Dates : June 26-27, 2014 1078 1114 W4293262509.pdf 0 27 separator 0.9695784 ¶ 1114 1116 W4293262509.pdf 0 28 paratext 0.8614956 "World Academy of Science, Engineering and Technology International Journal of Computer and Information Engineering Vol:8, No:6, 2014Open Science Index, Computer and Information Engineering Vol:8, No:6, 2014 waset.org/abstracts/10205" 1118 1355 W4293262509.pdf 0 29 separator 0.6810899 ¶ 1355 1357 W4293262509.pdf 0 30 paratext 0.97813165 ISNI:0000000091950263 International Scholarly and Scientific Research & Innovation 8(6) 2014 1 1357 1452 W4293262509.pdf 0 0 text 0.9939106 "location of one of them was sampled again. Features tested were: Transcriptional start sites (TSSs), transcrip- tional termination sites (TTSs), exons, and introns. TSSs and TTSs are considered to be the 500 bp upstream and downstream of coding regions respectively." 0 274 W2902435334.pdf 13 1 separator 0.9870415 ¶ 274 276 W2902435334.pdf 13 2 text 0.9986225 "The reason for the proposed novel resampling scheme is that, if the size and distribution of genomic features and hotspots were not taken into account, it would set unrealistic expectations for the overlap between features under a null model of no association. In this sense, the null model would be inappropriate and potentially in- flate the false positive rate." 276 653 W2902435334.pdf 13 3 separator 0.99500316 ¶ 653 655 W2902435334.pdf 13 4 title 0.9557622 Supplementary information 655 681 W2902435334.pdf 13 5 separator 0.96765363 ¶ 681 683 W2902435334.pdf 13 6 text 0.5869324 Supplementary information accompanies 683 721 W2902435334.pdf 13 7 paratext 0.6415111 this paper 721 732 W2902435334.pdf 13 8 text 0.66700006 at https://doi.org 732 751 W2902435334.pdf 13 9 paratext 0.5838565 /10 751 754 W2902435334.pdf 13 10 text 0.48502937 . 754 755 W2902435334.pdf 13 11 paratext 0.6859942 ¶ 1186/s12864-020-6746-2 755 781 W2902435334.pdf 13 12 text 0.5777045 . 781 782 W2902435334.pdf 13 13 separator 0.9923377 ¶ 782 784 W2902435334.pdf 13 14 caption 0.9729355 "Additional file 1: Table S1. The median of the upper and lower bounds of the 95% Credibility Interval for the trace of estimates of r(in cM/Mb) from all positions in the genome are presented for each population (i.e. Position L95 and Position U95). The upper and lower bounds of the 95% probability interval for the median estimate of rfor each population is also presented (i.e. Genome L95 and Genome U95)." 784 1202 W2902435334.pdf 13 15 separator 0.9915792 ¶ 1202 1204 W2902435334.pdf 13 16 text 0.9588355 "The quotients of the upper and lower bounds for each of the two intervals point to a much larger genome-wide variation in rthan per- position variation in the trace for the estimate of r." 1204 1396 W2902435334.pdf 13 17 caption 0.819064 "Table S2. Mean and median genome-wide recombination rates ( r) in cM/Mb for all ten T. ca- caopopulations obtained using LDhat with θ= 0.001. Table S" 1396 1549 W2902435334.pdf 13 18 table 0.35710415 3 1549 1550 W2902435334.pdf 13 19 caption 0.4214465 . 1550 1551 W2902435334.pdf 13 20 table 0.5912221 "Name of T. cacao gene coding for FIGL-1 and FLIP and amino acid mutations for FIGL-1 and FLIP orthologs. Table S4. Average hotspot size (in kb) and count for hotspots detected in each population and average for all popu- lations. The quotient of the average recombination rate within hotspots and the average genome-wide recombination rate is reported for each population. Table S5. Sample size and post-filtering SNP count for all ten populations of Theobroma cacao for which recombination maps were generated. The proportion of the genome that is callable is also reported." 1551 2143 W2902435334.pdf 13 21 separator 0.9837054 ¶ 2143 2145 W2902435334.pdf 13 22 text 0.8690667 "We also include the geographic location of the population and whether it is a domesticated variety." 2145 2247 W2902435334.pdf 13 23 bibliography 0.77122706 "Table S6. Pairwise F STvalues for the ten populations of Theobroma cacao. Values from Cornejo et al. (2018) [ 35]." 2247 2364 W2902435334.pdf 13 24 separator 0.9934305 ¶ 2364 2366 W2902435334.pdf 13 25 caption 0.96829224 "Figure S1. Drift tree constructed using treemix [ 80] for the 10 T. cacao populations. Distances between populations are based on the drift par- ameter. Modified from Cornejo et al. (2018) [ 35].Figure S2. Distribution oflog 10recombination rates ( log 10(r)) along the genomes of the ten T. ca- caopopulations. The sample size (N) is reported for each population. Fig- ure S3 . The left panel shows the frequency of individuals that are homozygous for the alternative allele of amino acid mutations in a T. ca- caoFLIP ortholog. Alternative allele is defined in terms of the Amelonado reference genome. The right panel shows" 2366 3008 W2902435334.pdf 13 26 text 0.63126725 the 3008 3012 W2902435334.pdf 13 27 caption 0.6193338 log 3012 3016 W2902435334.pdf 13 28 text 0.56514764 3016 3017 W2902435334.pdf 13 29 caption 0.60057247 etransformed recombin 3017 3038 W2902435334.pdf 13 30 text 0.52001435 "- " 3038 3042 W2902435334.pdf 13 31 caption 0.6854257 ation rates ( r). 3042 3059 W2902435334.pdf 13 32 text 0.6304377 The 3059 3063 W2902435334.pdf 13 33 caption 0.735814 population 3063 3074 W2902435334.pdf 13 34 text 0.55462044 s 3074 3075 W2902435334.pdf 13 35 caption 0.5120674 are 3075 3079 W2902435334.pdf 13 36 text 0.5402982 in the 3079 3086 W2902435334.pdf 13 37 caption 0.93241346 "same order in both panels. Fig- ure S4. Example of the window layout for a 10,750 SNP chromosome." 3086 3186 W2902435334.pdf 13 38 separator 0.98799384 ¶ 3186 3188 W2902435334.pdf 13 39 text 0.980446 "The 2000 SNP long windows are represented by alternating horizontal and vertical lines and the overlaps between them are represented by square crosshatches. Braces above the chromosome indicate the regions from which recombination rates are extracted to generate the chromosome-wide recombination rates." 3188 3500 W2902435334.pdf 13 40 separator 0.9962414 ¶ 3500 3502 W2902435334.pdf 13 41 title 0.9778345 Abbreviations 3502 3516 W2902435334.pdf 13 42 separator 0.9874064 ¶ 3516 3518 W2902435334.pdf 13 43 table 0.61844474 "TSSs: Transcriptional start sites; TTSs: Transcriptional termination sites; LD: Linkage disequilibrium; TEs: Transposable elements; SNPs: Single nucleotide polymorphisms; r: Recombination rate; N e: Effective population size; 4N er: Effective recombination rate; OU: Ornstein-Uhlenbeck" 3518 3810 W2902435334.pdf 13 44 separator 0.9961782 ¶ 3810 3812 W2902435334.pdf 13 45 title 0.9737992 Acknowledgements 3812 3829 W2902435334.pdf 13 46 separator 0.99357736 ¶ 3829 3831 W2902435334.pdf 13 47 text 0.995866 "The authors would like to thank the Noe Higinbotham endowment and the WSU College of Arts and Science for travel funds to EJS to present earlier versions of this work. We would like to thank the Kamiak High PerformanceComputing Cluster at WSU for the infrastructure support to run the analyses, and the Cornejo, Kelley, and Busch labs at WSU for feedback and edits on the manuscript." 3831 4223 W2902435334.pdf 13 48 separator 0.99637747 ¶ 4223 4225 W2902435334.pdf 13 49 title 0.98173624 Authors ’contributions 4225 4248 W2902435334.pdf 13 50 separator 0.9857253 ¶ 4248 4250 W2902435334.pdf 13 51 text 0.97366405 "OEC designed the experiments with contribution from JCM. EJS and OEC performed analyses. EJS wrote the manuscript with contribution from OEC. All authors reviewed the manuscript. The authors read and approved the final manuscript." 4250 4487 W2902435334.pdf 13 52 separator 0.9949528 ¶ 4487 4489 W2902435334.pdf 13 53 title 0.9829047 Funding 4489 4497 W2902435334.pdf 13 54 separator 0.99095166 ¶ 4497 4499 W2902435334.pdf 13 55 text 0.99356425 "EJS received Noe Higinbotham endowment and the WSU College of Arts and Science for travel funds to EJS to present earlier versions of this work. Startup funds for OEC were used for analysis infrastructure." 4499 4709 W2902435334.pdf 13 56 separator 0.9960741 ¶ 4709 4711 W2902435334.pdf 13 57 title 0.98670965 Availability of data and materials 4711 4746 W2902435334.pdf 13 58 separator 0.98720807 ¶ 4746 4748 W2902435334.pdf 13 59 text 0.99676067 "Rate and summary files from LDhat runs as well as hotspots for each population along with scripts for LDhat and LDhot runs, the resampling schemes used, and additional analyses is available in the following github repository: https://github.com/ejschwarzkopf/recombination-map ." 4748 5033 W2902435334.pdf 13 60 separator 0.9959486 ¶ 5033 5035 W2902435334.pdf 13 61 title 0.8255209 Ethics approval and consent to participate 5035 5078 W2902435334.pdf 13 62 separator 0.96014774 ¶ 5078 5080 W2902435334.pdf 13 63 paratext 0.582023 Not applicable. 5080 5096 W2902435334.pdf 13 64 separator 0.98397833 ¶ 5096 5098 W2902435334.pdf 13 65 title 0.6321258 Consent for 5098 5110 W2902435334.pdf 13 66 paratext 0.4432071 publication 5110 5122 W2902435334.pdf 13 67 separator 0.77360666 ¶ 5122 5124 W2902435334.pdf 13 68 paratext 0.6430566 Not 5124 5128 W2902435334.pdf 13 69 text 0.47785223 applicable 5128 5139 W2902435334.pdf 13 70 paratext 0.47653437 . 5139 5140 W2902435334.pdf 13 71 separator 0.99250805 ¶ 5140 5142 W2902435334.pdf 13 72 title 0.9070921 Competing interests 5142 5162 W2902435334.pdf 13 73 separator 0.9376259 ¶ 5162 5164 W2902435334.pdf 13 74 text 0.5584474 The authors declare that they have no competing interests. 5164 5223 W2902435334.pdf 13 75 separator 0.98643506 ¶ 5223 5225 W2902435334.pdf 13 76 contact 0.5377632 Author details 5225 5240 W2902435334.pdf 13 77 separator 0.8651028 ¶ 5240 5242 W2902435334.pdf 13 78 contact 0.9726428 "1School of Biological Sciences, Washington State University, Pullman, WA, USA.2Universal Genetic Solutions, LLC, Miami, USA." 5242 5369 W2902435334.pdf 13 79 separator 0.91807616 ¶ 5369 5371 W2902435334.pdf 13 80 paratext 0.98047394 Received: 10 February 2020 Accepted: 21 April 2020 5371 5422 W2902435334.pdf 13 81 separator 0.9857304 ¶ 5422 5424 W2902435334.pdf 13 82 title 0.7409954 References 5424 5435 W2902435334.pdf 13 83 separator 0.9608359 ¶ 5435 5437 W2902435334.pdf 13 84 bibliography 0.9974912 "1. Felsenstein J. The evolutionary advantage of recombination. Genetics. 1974; 78:737 –56." 5437 5530 W2902435334.pdf 13 85 separator 0.4916288 5530 5531 W2902435334.pdf 13 86 bibliography 0.98913705 "¶ 2. Begun DJ, Aquadro CF. Levels of naturally occurring DNA polymorphism correlate with recombination rates in D. melanogaster . Nature. 1992;356. https://doi.org/10.1038/356519a0 ." 5531 5717 W2902435334.pdf 13 87 separator 0.9431424 ¶ 5717 5719 W2902435334.pdf 13 88 bibliography 0.997976 "3. Akhunov E, Goodyear A, Geng S, Qi L, Echalier B, Gill B, Gustafson J, Lazo G, Chao S, Anderson O, et al. The organization and rate of evolution of wheat genomes are correlated with recombination rates along chromosome arms. Genome Res. 2003;13:753 –63.https://doi.org/10.1101/gr.808603 ." 5719 6016 W2902435334.pdf 13 89 separator 0.94590986 ¶ 6016 6018 W2902435334.pdf 13 90 bibliography 0.9979983 "4. Wu J, Mizuno H, Hayashi-Tsugane M, Ito Y, Chiden Y, Fujisawa M, Katagiri S, Saji S, Yoshiki S, Karasawa W, et al. Physical maps and recombination frequency of six rice chromosomes. Plant J. 2003;36:720 –30.https://doi.org/ 10.1046/j.1365-313X.2003.01903.x ." 6018 6285 W2902435334.pdf 13 91 separator 0.9289361 ¶ 6285 6287 W2902435334.pdf 13 92 bibliography 0.9978619 "5. Anderson L, Salameh N, Bass H, Harper L, Cande W, Weber G, Stack S. Integrating genetic linkage maps with Pachytene chromosome structure in maize. Genetics. 2004;166:1923 –33." 6287 6470 W2902435334.pdf 13 93 separator 0.9400414 ¶ 6470 6472 W2902435334.pdf 13 94 bibliography 0.99789834 "6. Mcvean G, Myers S, Hunt S, Deloukas P, Bentley D, Donnelly P. The fine- scale structure of recombination rate variation in the human genome. Science. 2004;304:581 –4." 6472 6646 W2902435334.pdf 13 95 separator 0.8619474 ¶ 6646 6648 W2902435334.pdf 13 96 bibliography 0.9978497 "7. Mézard C. Meiotic recombination hotspots in plants. Biochem Soc T. 2006; 34:531 –4." 6648 6737 W2902435334.pdf 13 97 separator 0.9452918 ¶ 6737 6739 W2902435334.pdf 13 98 bibliography 0.9980129 "8. Kim S, Plagnol V, Hu T, Toomajian C, Clark R, Ossowski S, Ecker J, Weigel D, Nordborg M. Recombination and linkage disequilibrium in Arabidopsis thaliana . Nat Genet. 2007;39:1151 –5.https://doi.org/10.1038/ng2115 ." 6739 6962 W2902435334.pdf 13 99 separator 0.9401108 ¶ 6962 6964 W2902435334.pdf 13 100 bibliography 0.99800265 "9. Gore MA, Chia J-M, Elshire RJ, Sun Q, Ersoz ES, Hurwitz BL, Peiffer JA, Mcmullen MD, Grills GS, Ross-Ibarra J, et al. A first-generation haplotype map of maize. Science. 2009;326:1115 –7.https://doi.org/10.1126/science. 1177837 ." 6964 7203 W2902435334.pdf 13 101 separator 0.9066705 ¶ 7203 7205 W2902435334.pdf 13 102 bibliography 0.9978513 "10. Schnable P, Ware D, Fulton R, Stein J, Wei F, Pasternak S, Liang C, Zhang J, Graves L, Minx T, et al. The B73 maize genome: complexity, diversity, and dynamics. Science. 2009;326:1112 –5.https://doi.org/10.1126/science. 1178534 .Schwarzkopf et al. BMC Genomics (2020) 21:332" 7205 7499 W2902435334.pdf 13 103 paratext 0.96558404 Page 14 of 16 7499 7513 W2902435334.pdf 13 0 paratext 0.94086945 "© 2012 The Author(s). Licensee IntechOpen. This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited." 0 282 W1531885424.pdf 18 0 text 0.9983607 "In conclusion, this first case demonstrates the feasibil- ity of the SETA MUG device design in which in-situ fen- estration of the stent graft membrane can be performed to treat aortic dissection with persistent false lumen flow. Pending further studies, this may soon become a new option in the endovascular therapy for patients with chronic abdominal aortic dissection such as our patient,as well as those patient anatomies with difficult landing zones (short and/or conical necks, etc.) or those with type1 A endoleaks, who might otherwise require fenes- trated stent grafts or fenestrated cuffs. Larger studies with longer follow-up are essential to fully evaluate the safety and effectiveness of this technology and the need of possible secondary procedures." 0 787 W3121461358.pdf 4 1 separator 0.96806896 ¶ 787 789 W3121461358.pdf 4 2 text 0.97665685 Approved by Leben Clinic ethics committee. 789 832 W3121461358.pdf 4 3 separator 0.99489194 ¶ 832 834 W3121461358.pdf 4 4 title 0.9894188 Informed consent 834 851 W3121461358.pdf 4 5 separator 0.9934534 ¶ 851 853 W3121461358.pdf 4 6 text 0.99644923 "Written informed consent was obtained from the patient for publications of this case report and any accompanying images." 853 976 W3121461358.pdf 4 7 separator 0.99620634 ¶ 976 978 W3121461358.pdf 4 8 title 0.9885844 Authors' contributions 978 1001 W3121461358.pdf 4 9 separator 0.99251986 ¶ 1001 1003 W3121461358.pdf 4 10 text 0.9979606 "HB wrote the paper and performed the surgery; GG and FC performed the surgery; HB made the devices used; AV performed all CT angiography studies and BB wrote a part of the paper. Dr T Maldonado collaborated in the writing of the paper. The author(s) read and approved the final manuscript." 1003 1299 W3121461358.pdf 4 11 separator 0.9964167 ¶ 1299 1301 W3121461358.pdf 4 12 title 0.98311925 Funding 1301 1309 W3121461358.pdf 4 13 separator 0.9885151 ¶ 1309 1311 W3121461358.pdf 4 14 text 0.99658394 This study was not supported by any funding. 1311 1356 W3121461358.pdf 4 15 separator 0.9955516 ¶ 1356 1358 W3121461358.pdf 4 16 title 0.986739 Availability of data and materials 1358 1393 W3121461358.pdf 4 17 separator 0.9764529 ¶ 1393 1395 W3121461358.pdf 4 18 text 0.9979204 all data related to the MUG device are property of the company Latecba. SA. 1395 1471 W3121461358.pdf 4 19 separator 0.9950991 ¶ 1471 1473 W3121461358.pdf 4 20 title 0.9891894 Ethics approval 1473 1489 W3121461358.pdf 4 21 separator 0.9856154 ¶ 1489 1491 W3121461358.pdf 4 22 text 0.99798167 "All procedures performed in studies involving human participants were in accordance with the ethical standards of the institucional and / or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards." 1491 1763 W3121461358.pdf 4 23 separator 0.99539566 ¶ 1763 1765 W3121461358.pdf 4 24 title 0.98850095 Consent for Publication 1765 1789 W3121461358.pdf 4 25 separator 0.9837179 ¶ 1789 1791 W3121461358.pdf 4 26 text 0.99718636 "Consent for publication was obtained for every individual person ́s data included in the study." 1791 1888 W3121461358.pdf 4 27 separator 0.9957714 ¶ 1888 1890 W3121461358.pdf 4 28 title 0.9786194 Competing interests 1890 1910 W3121461358.pdf 4 29 separator 0.9838479 ¶ 1910 1912 W3121461358.pdf 4 30 text 0.99084866 Dr Bertoni is a consultant to Latecba. SA. 1912 1955 W3121461358.pdf 4 31 separator 0.9962363 ¶ 1955 1957 W3121461358.pdf 4 32 title 0.7795422 Author details 1957 1972 W3121461358.pdf 4 33 separator 0.96941197 ¶ 1972 1974 W3121461358.pdf 4 34 contact 0.981691 "1Department of Interventional Radiology, Fleni Institute, Buenos Aires University, Caba, Argentina.2Department of Cardiovascular Surgery, Laben, Rio Negro, Argentina.3Latecba, SA, Buenos Aires, Argentina.4Department of Interventional Radiology, Sherbrooke University, Sherbrooke, Canada. 5Department of Vascular Surgery, NYU University, New York, USA." 1974 2334 W3121461358.pdf 4 35 separator 0.9279564 ¶ 2334 2336 W3121461358.pdf 4 36 paratext 0.97771835 Received: 15 November 2020 Accepted: 19 January 2021 2336 2389 W3121461358.pdf 4 37 separator 0.9900199 ¶ 2389 2391 W3121461358.pdf 4 38 title 0.9216895 REFERENCES 2391 2402 W3121461358.pdf 4 39 separator 0.9904001 ¶ 2402 2404 W3121461358.pdf 4 40 bibliography 0.99708164 "1. KölbelT,TsilimparisN,WipperS,Larena-AvellanedaA,DienerH,CarpenterSW,etal. TEVAR for chronic aortic dissection. Is covering the primary entry tear enough?J Cardiovasc Surg2014;55:519 –527." 2404 2599 W3121461358.pdf 4 41 separator 0.94707525 ¶ 2599 2601 W3121461358.pdf 4 42 bibliography 0.9973211 "2. Rosset E, Ben Ahmed S, Galvaing G, Favre JP, Sessa C, Lermusiaux P,etal. (ed) ’schoice- hybridtreatmentofthoracic,thoracoabdominal,andabdominalaorticaneurysms: amulti-centerretrospectivestudy. Eur J Vasc Endovasc Surg 2014;47:470 –478" 2601 2845 W3121461358.pdf 4 43 separator 0.96232605 ¶ 2845 2847 W3121461358.pdf 4 44 bibliography 0.99772877 "3. Marques de MarinoP,OikonomouK,VerhoevenE,KatsargysA.Techniques and Outcomes of Secondary Endovascular Repair for Post-disection TAA/TAAA.J Cardiovasc Surg (Torino)2018Dec;59(6):767 –774." 2847 3041 W3121461358.pdf 4 45 separator 0.96946627 ¶ 3041 3043 W3121461358.pdf 4 46 bibliography 0.99672264 "4. Andersen N, Keenan J, Ganapathi A, Gaca J, McCann R, Hughes G (2014) Current management and outcome of chronic type B aortic dissection: results with open and endovascular repair since the advent of thoracic endografting. Ann Cardiothorac Surg 3:264 –274" 3043 3307 W3121461358.pdf 4 47 separator 0.9715141 ¶ 3307 3309 W3121461358.pdf 4 48 bibliography 0.9974186 "5. Spear R, Sobocinski J, Settembre N, Tyrrell MR, Malikov S, Maurel B (2016) etal.Early experience of endovascular repair of post- dissection aneurysms involving the thoraco-abdominal aorta and the arch. Eur J Vasc Endovasc Surg 51:488 –497" 3309 3557 W3121461358.pdf 4 49 separator 0.9872436 ¶ 3557 3559 W3121461358.pdf 4 50 caption 0.9875749 "Fig. 4 Eight months follow-up. aAxial contrast-enhanced image showing the left renal branch without re- stenosis and decrease in size of the residual aneurysmal sac. b3D reconstruction showing patency of all abdominal aortic branches as well as both hypogastric arteriesBertoni et al." 3559 3852 W3121461358.pdf 4 51 bibliography 0.6012888 CVIR Endovascular 3852 3870 W3121461358.pdf 4 52 caption 0.47688532 (2021) 3881 3888 W3121461358.pdf 4 53 bibliography 0.3445117 3888 3889 W3121461358.pdf 4 54 caption 0.40042165 4:19 3889 3893 W3121461358.pdf 4 55 paratext 0.9779414 Page 5 of 6 3893 3905 W3121461358.pdf 4 0 paratext 0.98953503 Remote Sens. 2018 ,10, 1823 14 of 23 0 36 W2901969700.pdf 13 1 separator 0.9903549 ¶ 36 38 W2901969700.pdf 13 2 text 0.9969183 "15.2%. The latter value is similar to the RMSE between KazVodKhoz data and the L7/MOD irrigated areas (16.0%, Table 2)." 38 160 W2901969700.pdf 13 3 separator 0.9557241 ¶ 160 162 W2901969700.pdf 13 4 text 0.9937528 "At the Kazakh side of the Chu basin the determined annual irrigated areas are in general very consistent with available KazVodKhoz data (Figure 8). The RMSE between the two datasets for the period 2010–2015 is 47 km2, which represents about 5% of the annual irrigated areas (Table 2). " 162 452 W2901969700.pdf 13 5 separator 0.561882 ¶ 452 453 W2901969700.pdf 13 6 text 0.99910766 "However, the error is much larger for the year 2016, where the calculated acreages overestimate the reference data by 365 km2or 59%." 453 588 W2901969700.pdf 13 7 separator 0.99561906 ¶ 588 590 W2901969700.pdf 13 8 title 0.8003178 Table 2. Summary error and uncertainty statistics of annual irrigated areas derived from the L7/MOD 590 690 W2901969700.pdf 13 9 table 0.5338061 ¶ product. ‘Buffer’ represents the mean uncertainty that is due to the uncertainty in optimal buffer 690 792 W2901969700.pdf 13 10 text 0.460692 ¶ 792 793 W2901969700.pdf 13 11 table 0.46181607 widths 793 800 W2901969700.pdf 13 12 text 0.47527736 around image training regions. The values 800 842 W2901969700.pdf 13 13 table 0.47496212 in 842 846 W2901969700.pdf 13 14 text 0.45044455 columns 846 853 W2901969700.pdf 13 15 table 0.5171912 ‘L7/MYD’ and ‘L7/L8/S2’ represent 853 887 W2901969700.pdf 13 16 text 0.5008091 the 887 892 W2901969700.pdf 13 17 table 0.48839334 ¶ 892 893 W2901969700.pdf 13 18 text 0.5269679 RMSE of the two products 893 918 W2901969700.pdf 13 19 table 0.49889445 with respect to 918 934 W2901969700.pdf 13 20 text 0.5222305 L7/MOD. 934 942 W2901969700.pdf 13 21 table 0.5091087 ‘KazVod 942 950 W2901969700.pdf 13 22 text 0.48576713 Khoz’ 950 955 W2901969700.pdf 13 23 table 0.56956387 "are data provided by the Zhambyl branch of the Republican State Enterprise with" 955 1037 W2901969700.pdf 13 24 text 0.58655053 "the same name and the values here represent the RMSE with respect to L7/MOD annual irrigated areas." 1037 1139 W2901969700.pdf 13 25 separator 0.98449075 ¶ 1139 1141 W2901969700.pdf 13 26 table 0.99542654 "Buffer 2000–2017 L7/MYD 2003–2017 L7/L8/S2 2013–2017 KazVodKhoz 2010–2016 Talas (KYG) 1.4% 1.8% 2.3% - Talas (KAZ) 2.7% 4.5% 15.2% 16.0% Talas 1.8% 2.6% 4.2% - Chu (KYG) 2.7% 1.5% 1.7% - Chu (KAZ) 4.5% 8.2% 5.0% 16.9% * Chu 2.9% 3.7% 2.0% - * KazVodKhoz 2010–2015: 5.1%." 1141 1426 W2901969700.pdf 13 27 separator 0.9966253 ¶ 1426 1428 W2901969700.pdf 13 28 title 0.99198914 5.2. Classification of Irrigated Areas 1428 1466 W2901969700.pdf 13 29 separator 0.99627787 ¶ 1466 1468 W2901969700.pdf 13 30 text 0.99883956 "Using the boundaries of the administrative divisions, we calculate the development of irrigated areas at national levels (Figures 8 and 9). Over the assessment period, the mean irrigated area in the Talas Basin is 2038 km2and 3840 km2in the Chu Basin, respectively (Table 3)." 1468 1748 W2901969700.pdf 13 31 separator 0.9762304 ¶ 1748 1750 W2901969700.pdf 13 32 table 0.99194723 "0200040006000Irrigated Area [km2] 200020012002200320042005200620072008200920102011201220132014201520162017Total (L7/MYD) Total (L7/MOD) Total (L7/L8/S2) Kyrgyzstan (L7/MYD) Kyrgyzstan (L7/MOD) Kyrgyzstan (L7/L8/S2) Kazakhstan (L7/MYD) Kazakhstan (L7/MOD) Kazakhstan (L7/L8/S2) Kazakhstan (KazVodKhoz)0 100 200 300 400 500 Precipitation [mm]Kyrgyzstan (pre-season) Kyrgyzstan (in-season) Kazakhstan (pre-season) Kazakhstan (in-season)" 1750 2222 W2901969700.pdf 13 33 separator 0.98797715 ¶ 2222 2224 W2901969700.pdf 13 34 caption 0.98955965 "Figure 8. Development of irrigated area and corresponding total seasonal precipitation time series (CHIRPS dataset) in the Chu River Basin and the riparian sections for the years 2000–2017. L7/MOD, L7/MYD and L7/L8/S2 are the different multi-sensor classification products. Error bars represent the standard deviation in results obtained with training regions buffered by 2000 m–6000 m (Figure 3)." 2224 2627 W2901969700.pdf 13 35 separator 0.65602833 ¶ 2627 2629 W2901969700.pdf 13 36 caption 0.7290219 "’KazVodKhoz’ are data provided by the Zhambyl branch of the Republican State Enterprise with the same name" 2629 2738 W2901969700.pdf 13 37 text 0.47019333 . 2738 2739 W2901969700.pdf 13 38 separator 0.97792697 ¶ 2739 2741 W2901969700.pdf 13 39 text 0.99693626 "For the Kyrgyz part of the Talas basin, we identify a robust increasing trend in irrigated areas over time that is highly significant (at the 0.001 level, see Table 3). The trend indicates that since the year 2000, irrigated areas are on average increasing by 14.5 km2per year, which corresponds to a total" 2741 3051 W2901969700.pdf 13 0 title 0.9883908 Supplementary Table 2. Association of serglycin expression and clinicopathological 0 84 W4362240421.pdf 1 1 separator 0.78840584 ¶ 86 88 W4362240421.pdf 1 2 title 0.9555107 characteristics of patients with NPC 88 125 W4362240421.pdf 1 3 separator 0.984056 ¶ 126 128 W4362240421.pdf 1 4 table 0.9910932 "Characteristic Number Serglycin expression level P value (Chi- square test) High Low Gender Male 199 90 109 0.187 Female 64 35 29 Age ≤ 46 133 65 68 0.659 > 46 130 60 70 T stage T1-2 100 48 52 0.905 T3-4 163 77 86 N stage N0-1 160 71 89 0.202 N2-3 103 54 49 Clinical staging I-II 65 30 35 0.798 III-IV 198 95 103 Death Yes 102 55 47 0.098 No 161 70 91 Disease progression Yes 57 35 22 0.018 No 206 90 116 Distant metastasis Yes 38 26 12 0.005 No 225 99 126 Loco-regional relapse Yes 20 10 10 0.818 No 243 115 128 ¶" 128 799 W4362240421.pdf 1 5 separator 0.8553366 "¶ ¶" 801 811 W4362240421.pdf 1 0 paratext 0.9895013 Foods 2024 ,13, 1417 8 of 15 0 28 W4396666201.pdf 7 1 separator 0.59198844 28 29 W4396666201.pdf 7 2 paratext 0.96442 ¶ Foods 2024 , 13, x FOR PEER REVIEW 9 of 17 29 73 W4396666201.pdf 7 3 separator 0.9260097 "¶ ¶" 74 85 W4396666201.pdf 7 4 caption 0.9908592 Figure 3. ACN suppressed oxidative stress and oxidativ e stress-induced apoptosis in H9c2 cells. 85 182 W4396666201.pdf 7 5 separator 0.9882598 ¶ 183 185 W4396666201.pdf 7 6 caption 0.7576908 H9c2 cells were initially treated with H 2O2 and subsequently exposed to di fferent concentrations of ¶ 185 289 W4396666201.pdf 7 7 text 0.53542316 ACN 289 293 W4396666201.pdf 7 8 caption 0.7530304 ( 293 295 W4396666201.pdf 7 9 text 0.6002636 0.625, 1.25 295 306 W4396666201.pdf 7 10 caption 0.9824717 ", and 2.5 μM). ( A) Cell viability assessed by CCK8 assay. ( B,C) Intracellular ROS levels. ( D,E) Flow cytometry analysis of apoptosis. ( F,G) Transmission electron microscopy images of cellular mitochondria, showing the proportion of abnormal mito chondria to total mitochondria." 306 593 W4396666201.pdf 7 11 separator 0.49338728 ¶ 594 596 W4396666201.pdf 7 12 caption 0.88825375 "(H–J) Expression levels of cleaved caspase-3, Bax, and Bcl-2 proteins in cells, as well as the ratio of BAX/Bcl-2 expression level. **: p < 0.01, *** (###): p < 0.001, **** (####): p < 0.0001. p-values for differences between cohorts in mean scores in tests are based on analysis of variance (one-way ANOVA)." 596 913 W4396666201.pdf 7 13 separator 0.99564 ¶ 914 916 W4396666201.pdf 7 14 title 0.987285 "3.3. RNA-seq Reveals That the Antioxidant E ffect of ACN Operates through the PTEN-Akt Pathway" 916 1013 W4396666201.pdf 7 15 separator 0.9913014 ¶ 1014 1016 W4396666201.pdf 7 16 text 0.9995448 "Through the aforementioned experiments, we observed that ACN exhibits signi ficant antioxidative e ffects on H9c2 cells. However, the molecular mechanisms underlying its actions remain unclear. RNA-seq can be used to explore the potential molecular mechanisms of drugs. Therefore, we divided H9c2 cells into four groups for mRNA-seq analysis: the control group (CK), the hydrogen peroxide-treated group (H 2O2), the anthocyanin-treated group (ACN), and the group treated with anthocyanin combined with hydrogen peroxide (ACN + H 2O2). The gene expression levels of each group are illustrated in Figure 4A. Subsequently, hierarchical clustering analysis was conducted for each group, as shown in Figure 4B, indi cating alterations in the expression pa tterns of genes across groups. Following this, we conducted KEGG functional annotation and pathway analysis on these di fferentially expressed genes and generated metabolic" 1016 1967 W4396666201.pdf 7 17 separator 0.98654777 ¶ 1968 1970 W4396666201.pdf 7 18 caption 0.9891234 Figure 3. ACN suppressed oxidative stress and oxidative stress-induced apoptosis in H9c2 cells. 1970 2066 W4396666201.pdf 7 19 separator 0.93442523 ¶ 2066 2068 W4396666201.pdf 7 20 caption 0.7308515 "H9c2 cells were initially treated with H 2O2and subsequently exposed to different concentrations of ACN (0.62" 2068 2180 W4396666201.pdf 7 21 text 0.44097656 5 2180 2181 W4396666201.pdf 7 22 caption 0.95870304 ", 1.25, and 2.5 μM). ( A) Cell viability assessed by CCK8 assay. ( B,C) Intracellular ROS levels. ( D,E) Flow cytometry analysis of apoptosis. ( F,G) Transmission electron microscopy images of cellular mitochondria, showing the proportion of abnormal mitochondria to total mito- chondria. ( H–J) Expression levels of cleaved caspase-3, Bax, and Bcl-2 proteins in cells, as well as the ratio of BAX/Bcl-2 expression level. **: p< 0.01, *** (###): p< 0.001, **** (####): p< 0.0001." 2181 2668 W4396666201.pdf 7 23 separator 0.7904192 ¶ 2668 2670 W4396666201.pdf 7 24 caption 0.77950567 "p-values for differences between cohorts in mean scores in tests are based on analysis of variance (one-way ANOVA)." 2670 2788 W4396666201.pdf 7 25 separator 0.9896709 ¶ 2788 2790 W4396666201.pdf 7 26 text 0.99925244 "Cellular oxidative stress damage is often associated with apoptosis. Therefore, we assessed the anti-apoptotic capability of ACN in the H9c2 cellular oxidative stress model using flow cytometry, as depicted in Figure 3D,E. We observed that ACN significantly reduced H9c2 cell apoptosis induced by hydrogen peroxide in a dose-dependent manner." 2790 3139 W4396666201.pdf 7 27 separator 0.94984025 ¶ 3139 3141 W4396666201.pdf 7 28 text 0.99965996 "Given the mitochondria-related nature of apoptosis, we investigated the mitochondrial status in cells from each group using transmission electron microscopy (Figure 3D). The results revealed that oxidative stress induced by hydrogen peroxide led to mitochondrial vacuolization in H9c2 cells, with abnormal mitochondria accounting for over 60% of the total mitochondrial population. Supplementation with ACN significantly decreased the proportion of abnormal mitochondria in cells (Figure 3F). Furthermore, we evaluated the expression of apoptosis-related proteins within cells, including BAX, Bcl-2, and cleaved caspase-3 (Figure 3H–J). We found that ACN supplementation dose-dependently reduced the levels of the apoptosis proteins BAX and cleaved caspase-3 induced by oxidative stress" 3141 3944 W4396666201.pdf 7 0 paratext 0.9578037 "Volume 8, Issue 7, July – 2023 International Journal of Innovative Science and Research Technology ISSN No: -2456 -2165 ¶ IJISRT2 3JUL2403 www.ijisrt.com 2677" 0 433 W4385849969.pdf 2 1 text 0.6653819 "and Copper Sulphate (CuSO4), Ammonium Mole date (NH4) 6Mo7O24). EC was maintained at standard level." 434 540 W4385849969.pdf 2 2 separator 0.54091054 ¶ 541 543 W4385849969.pdf 2 3 text 0.976816 "According to growth stage of the plant, fertilizer requireme nt was calculated . ¶  Other than that, all the Management Practices were done According to the Recommendation for the Tomato ." 543 744 W4385849969.pdf 2 4 separator 0.86943454 "¶ " 745 753 W4385849969.pdf 2 5 title 0.9928657 Leaf Color Comparison 753 775 W4385849969.pdf 2 6 separator 0.931885 ¶ ¶ 777 783 W4385849969.pdf 2 7 title 0.93478405  By using Leaf Color Chart 783 811 W4385849969.pdf 2 8 separator 0.94224274 ¶ 813 815 W4385849969.pdf 2 9 text 0.99943554 "Leaf color was measured and compared among five treatments. Using the RHS color chart gives the standard references for recording plant colors which are developed by ‘Royal Horticultural Society’." 815 1021 W4385849969.pdf 2 10 separator 0.9697058 ¶ ¶ 1023 1029 W4385849969.pdf 2 11 title 0.875239  By using Image J Software 1029 1057 W4385849969.pdf 2 12 separator 0.9892498 ¶ 1059 1061 W4385849969.pdf 2 13 text 0.99959606 "All leaves from each plant were laid on a white background to ensure that the photograph would have only two col ors with the highest contrast. It is also mandatory that no other object appear in the photograph because they may be mistakenly included as part of leaves. For this study, all leaves were placed with the upper side facing upward while capturing no flash was used. All the photographs were taken inside a dark room and so a white light was used. In that case a fluorescent lamp of 100 watts bulb was used. All this, in order to get the same light conditions to all the photographs. Then photographs were c aptured and fed to the software to measure color intensity." 1061 1780 W4385849969.pdf 2 14 separator 0.9933181 ¶ ¶ 1782 1788 W4385849969.pdf 2 15 title 0.993546 III. STATISTICAL ANALYSIS 1788 1814 W4385849969.pdf 2 16 separator 0.9921885 ¶ ¶ 1816 1822 W4385849969.pdf 2 17 text 0.9996016 "The experiment was a completely randomized design with five Nitrogen treatments. the five treatments were, T1 - complete nutrient solution with excess Nitrogen, T2 - complete nutrient solution with optimum Nitrogen level. and T3 (critical) , T4, and T5 treatments were the complete nutrient solutions with dearth Nitrogen levels. Ten plants were all ocated for each treatment. Data entering and analysis was done using Microsoft Excel. Data was analyzed using SAS software. All the parametric data was analyzed by using ANOVA (Analysis of Variance) . Mean separation by Duncan’s multiple tests ." 1822 2449 W4385849969.pdf 2 18 separator 0.9881386 ¶ ¶ 2450 2456 W4385849969.pdf 2 19 title 0.9916275 IV. DISCUSSION 2456 2471 W4385849969.pdf 2 20 separator 0.99535835 ¶ ¶ 2473 2479 W4385849969.pdf 2 21 title 0.9902051 Table 1 Table of Leaf Color Chart Results 2479 2521 W4385849969.pdf 2 22 separator 0.9867867 ¶ ¶ 2523 2529 W4385849969.pdf 2 23 text 0.9997157 "Considering leaf color chart results, in 5th, 6th and 7th weeks, colors of the T4 and T5 were belongs to yellow green group and other colors were belongs to green group. However, use of visible green color -based detection of the least deficient (12.5%, les ser than optimum) N in T3 could be done only at the 7th week. ( Table 1 ). Week 1,2 and 3 were showed green group colors and it was difficult to identified." 2529 2953 W4385849969.pdf 2 24 separator 0.6470457 "¶ ¶ " 2955 2968 W4385849969.pdf 2 25 math 0.3085833 ¶ 2968 2969 W4385849969.pdf 2 26 separator 0.29670325 2971 2972 W4385849969.pdf 2 27 math 0.29157177 "¶ ¶ ¶" 2972 2985 W4385849969.pdf 2 28 separator 0.2829895 2987 2988 W4385849969.pdf 2 29 math 0.30158678 ¶ 2988 2989 W4385849969.pdf 2 30 separator 0.6839367 "¶ ¶ ¶" 2991 3005 W4385849969.pdf 2 31 title 0.47861236 Week 02 Week 03 3007 3024 W4385849969.pdf 2 32 table 0.48442858 Week 04 Week 05 Week 06 Week 07 3025 3060 W4385849969.pdf 2 33 separator 0.97907543 ¶ 3062 3064 W4385849969.pdf 2 34 table 0.9936096 "T1 Strong yellow green color Strong yellow green color Strong yellow green color Moderate olive green Moderate olive green Moderate olive green T2 Strong yellow green color Strong yellow green color Strong yellow green color Moderate olive green Moderate olive green Moderate olive green T3 Strong yellow green color Strong yellow green color Strong yellow green color Moderate olive green Strong yellow green A Brilliant yellow Green Yellow green group T4 Strong yellow green color Strong yellow green color Strong yellow green color Moderate yellow green Yellow green group Strong yellow green B Yellow green group Strong greenish yellow b Yellow green group T5 Strong yellow green color Strong yellow green color Strong yellow green color Moderate yellow green Yellow green group Strong yellow green B Yellow green group Strong greenish yellow Yellow green group" 3064 4103 W4385849969.pdf 2 0 bibliography 0.6184945 A 0 1 W2928738543.pdf 8 1 paratext 0.45293292 cknowledgments 1 15 W2928738543.pdf 8 2 bibliography 0.6641513 . 15 16 W2928738543.pdf 8 3 text 0.654953 "The authors wish to acknowledge the services of the Lifelines cohort study, the contributing research centers delivering data toLifelines and all the study participants. The authors declare no conflicts of interest." 16 236 W2928738543.pdf 8 4 separator 0.9912485 ¶ 236 238 W2928738543.pdf 8 5 text 0.96170807 "Financial support. During the first six months, this work was supported by the University of Groningen, University Medical Center Groningen as part of PhD thesis and later, it was supported by a NWO STAR travel grant from theUniversity of Groningen. For the remaining work, this research received no spe- cific grant from any funding agency, commercial or not-for-profit sectors." 238 624 W2928738543.pdf 8 6 separator 0.98951656 ¶ 624 626 W2928738543.pdf 8 7 paratext 0.5138453 Reference 626 636 W2928738543.pdf 8 8 title 0.608893 s 636 637 W2928738543.pdf 8 9 separator 0.9803983 ¶ 637 639 W2928738543.pdf 8 10 bibliography 0.99801886 "Almasy, L., & Blangero, J. (1998). Multipoint quantitative-trait linkage analysis in general pedigrees. 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Obesity ,16, 2323 –2330.12 Nino Demetrashvili et al ." 8228 8476 W2928738543.pdf 8 93 separator 0.9760234 ¶ 8476 8478 W2928738543.pdf 8 94 paratext 0.8797284 https://doi 8478 8490 W2928738543.pdf 8 95 bibliography 0.5818129 . 8490 8491 W2928738543.pdf 8 96 paratext 0.9681825 org/10.1017/thg.2019.1 Published online by Cambridge University Press 8491 8561 W2928738543.pdf 8 0 paratext 0.98892087 Toxins 2019 ,11, 204 5 of 12 0 28 W2929914955.pdf 4 1 separator 0.6321479 ¶ 28 30 W2929914955.pdf 4 2 paratext 0.8934729 "Toxins 2019, 11, x FOR PEER REVIEW 6 of 14 ¶ (a) ¶ (b)" 30 97 W2929914955.pdf 4 3 separator 0.919815 ¶ ¶ 97 103 W2929914955.pdf 4 4 caption 0.9901302 "Figure 5. Sequence alignments of the full‐length open‐reading frames of prepro‐ranatensin ‐HLa and the precursors with the highest sequence homology in the bioinformatic analysis using NCBI‐BLAST nucleotide and protein database. (a) Ranatensin ‐HLa ORF and a bombesin ‐like peptide (odorranain ‐ BLP‐4) precursor (Odorrana grahami ) (Accession number: DQ836112.1) showed 92% of sequence identity; (b) Ranatensin ‐HLa ORF and a bombesin (bombesin ‐OS) precursor (Odorrana schmackeri ) (Accession number: ATP61827.1) showed 90% of sequence identity." 103 684 W2929914955.pdf 4 5 separator 0.9962524 ¶ 685 687 W2929914955.pdf 4 6 title 0.99400204 2.3. Pharmacological Effects of Ranatensin ‐HLa on Rat Smooth Muscles 687 758 W2929914955.pdf 4 7 separator 0.99466956 ¶ 759 761 W2929914955.pdf 4 8 text 0.9991469 "The purified synthetic replicates of ranatensin ‐HLa were used to assess the biological activities on isolated bladder and uterus muscle strips, in which it exhibited pacific pharmacological activities on stimulating contraction of bladder and enhancing the periodicity of spontaneously contractive activity of uterus with EC 50 values of 7.1 nM and 5.5 nM in a dose‐dependent manner (Figure 6)." 761 1180 W2929914955.pdf 4 9 table 0.8744092 "40 Odorranain-BLP-4 40 Ranatensin-HLa Consensus aA A tT T gG G aA A cC C tT T gG G cC CA G gG G tT T tT T cC C cC C tT T gG G cC C cC C aA A tT T cC C aA A gG G aA A aA A tT T cC C cC C tT T gG G cC C cC C cC C aA A tT T tT T gG G gG GC G tT T 80 Odorranain-BLP-4 80 Ranatensin-HLa Consensus tT T cC C cC C tT T gG G gG GC G tT T aA A tT T tT T cC C tT T gG G cC C tT T gG G cC C tT T cC C tT T tT T cC C tT T cC C cC CG A tT T cC C aA A tT T cC C tT T cC C cC C cC C gG G cC C tT T cC C 120 Odorranain-BLP-4 120 Ranatensin-HLa Consensus tT T gG G tT T tT T tT T gG G cC C gG G tT TG A gG G aA AG T tT T tT T cC C aA AT C gG G gG G aA A aA A gG G aA A tT T gG G cC C tT T gG G gG G aA A aA A aA A aA A cC C tT T aA A gG G aA A cC C 160 Odorranain-BLP-4 160 Ranatensin-HLa Consensus aA A aA A aA A aA A tT T cC C gG G aA A tT T gG G cC C gG G tT T tT T tT T cC C gG G gG G aA A gG G aA A gG GC A aA A gG G cC C aA A cC C aA A aA A aA AG AA T gG GA GG AT G aA A tT T cC C 200 Odorranain-BLP-4 200 Ranatensin-HLa Consensus gG G aA A gG G cC C aA A cC C cC C tT T cC C aA AT G tT T gG G gG G gG G cC C aA AA G tT T tT T gG G gG G aA A cC C aA A cC C tT T tT T cC C aA A tT T gG G gG G gG G tT T aA A aA A gG G aA A aA A 219 Odorranain-BLP-4 219 Ranatensin-HLa Consensus gG G aA A gG G cC C cC C tT TG A cC C aA AG A gG G aA A aA A gG G aA A tT T tT T aA A gG G ¶ 40 Bombesin-OS 40 Ranatensin-HLa Consensus mM M tT T aA A vV V pP P aA A iI I rR R iI I lL L pP PV I gG G fF F lL L gG G iI I lL L lL L lL L fF F sS SV I iI I sS S rR R sS S vV V cC C vV VE D fF FA T eE E dD D aA A gG G kK K lL L dD D 72 Bombesin-OS 72 Ranatensin-HLa Consensus kK K iI I dD D aA A fF F rR R rR R eE E aA A qQ Q nN NT GY D rR R aA A pP P qQ Q wW W aA A vV V gG G hH HL F mM M gG G kK K kK K sS S lL L qQ Q eE E dD D ¶" 1184 4177 W2929914955.pdf 4 10 separator 0.9795726 ¶ 4179 4181 W2929914955.pdf 4 11 caption 0.9859402 "Figure 5. Sequence alignments of the full-length open-reading frames of prepro-ranatensin-HLa and the precursors with the highest sequence homology in the bioinformatic analysis using NCBI-BLAST nucleotide and protein database. ( a) Ranatensin-HLa ORF and a bombesin-like peptide (odorranain-BLP-4) precursor (Odorrana grahami ) (Accession number: DQ836112.1) showed 92% of sequence identity; ( b) Ranatensin-HLa ORF and a bombesin (bombesin-OS) precursor ( Odorrana schmackeri ) (Accession number: ATP61827.1) showed 90% of sequence identity ." 4181 4736 W2929914955.pdf 4 12 separator 0.996565 ¶ 4736 4738 W2929914955.pdf 4 13 title 0.9943229 2.3. Pharmacological Effects of Ranatensin-HLa on Rat Smooth Muscles 4738 4807 W2929914955.pdf 4 14 separator 0.99560255 ¶ 4807 4809 W2929914955.pdf 4 15 text 0.99944234 "The purified synthetic replicates of ranatensin-HLa were used to assess the biological activities on isolated bladder and uterus muscle strips, in which it exhibited pacific pharmacological activities on stimulating contraction of bladder and enhancing the periodicity of spontaneously contractive activity of uterus with EC 50values of 7.1 nM and 5.5 nM in a dose-dependent manner (Figure 6)." 4809 5207 W2929914955.pdf 4 16 separator 0.9907387 ¶ 5207 5209 W2929914955.pdf 4 17 paratext 0.9155683 "Toxins 2019 , 11, x FOR PEER REVIEW 7 of 14 ¶ (a) ¶ (b)" 5209 5277 W2929914955.pdf 4 18 separator 0.9948148 ¶ 5278 5280 W2929914955.pdf 4 19 caption 0.9963891 "Figure 6. Myotropic effects of synthetic ranatensin -HLa on isolated smooth muscle preparations from rat bladder and uterus. ( a) Dose -response curve of the effectiveness of ranatensin-HLa on bladder smooth muscle s (EC 50 = 7.1 nM ); (b) Dose -response curve of the effec tiveness of ranatensin-HLa on uterus smooth muscle s (EC 50 = 5.5 nM ). Five determinations were conducted for the generation of each data point." 5280 5714 W2929914955.pdf 4 20 separator 0.99619985 ¶ 5716 5718 W2929914955.pdf 4 21 title 0.9908345 3. Discussion 5718 5732 W2929914955.pdf 4 22 separator 0.9960847 ¶ 5734 5736 W2929914955.pdf 4 23 text 0.99956644 "In recent years, natural drug discovery has been intensified and extended to structurally - and func tionally -diverse compounds of amphibian origin. In reality, since ancient times, amphibian - derived substances have been applied for many conditions; for instance, the skin secretion of poison - dart frogs have been used for the purpose of effective hunting b y Native Americans up to the present [26,27] , and Chan Su, processed from the dried skin secretion of Bufo bufo gargarizans Cantor or Bufo melanostictus Schneider with the efficacy of detoxification , has been a n important traditional remedy for around 3000 years [28–31]. With the advancement in the technologies of isolation, identification and analysis, it has been recognised that the skin of amphibians is an extraordinary arsenal of a plethora of biologically -active components possessing diverse pharmacological properti es [7–9]." 5736 6666 W2929914955.pdf 4 24 separator 0.971068 ¶ 6667 6669 W2929914955.pdf 4 25 text 0.94572794 These bioactive compounds are endogenously produced and deposite d in granular glands , being ¶ 6669 6768 W2929914955.pdf 4 26 math 0.7249582 -2 -1 0 1 2 3 40.00.20.40.60.81.01.2 ¶ 6768 6807 W2929914955.pdf 4 27 table 0.73187387 "Log [peptide] (nM)Tension change (g) ¶ -2 -1 0 1 2 3 4036912 Log [peptide] (nM)Number of peak change of spontaneous contraction" 6807 6944 W2929914955.pdf 4 28 separator 0.9892222 ¶ 6944 6946 W2929914955.pdf 4 29 caption 0.9836097 Figure 6. Cont . 6946 6963 W2929914955.pdf 4 0 title 0.9177278 Background 0 10 W3014360692.pdf 1 1 separator 0.99576914 ¶ 10 12 W3014360692.pdf 1 2 text 0.9994896 "Meniscal extrusion induces dysfunction of load distribu- tion, one of the most important functions of the meniscus [1–3]. It is caused by the disruption of the meniscus hoop function and is often observed after meniscectomy [ 1,4], meniscus root tears [ 5], and with aging [ 6–8]. Meniscal extrusion initiates osteoarthritis (OA) and accompanies its progression [ 9–11]. Restoring the lost function caused by meniscus extrusion can delay OA progression [ 12]." 12 486 W3014360692.pdf 1 3 separator 0.82287383 ¶ 486 488 W3014360692.pdf 1 4 text 0.9996204 "A centralization technique has been developed to reduce meniscal extrusion; the capsule attached to the meniscus is sutured to the edge of the tibial plateau using suture an- chors [ 13]. Arthroscopic centralization of the extrudedlateral meniscus (LM) improved clinical outcomes at two- year follow-up [ 14]. It also increased the radiographic lat- eral joint space width on standing at the 45° flexion view at 3 months; this was maintained for 2 years [ 14]." 488 961 W3014360692.pdf 1 5 separator 0.9415528 ¶ 961 963 W3014360692.pdf 1 6 text 0.9993357 "Biomechanical studies examining the effects of centralization are still limited, although some papers were recently published [ 15–17]. We already reported the biomechanical analysis of the centralization procedure for extruded LM with posterior root deficiency in a por- cine model. Although this study showed that the centralization procedure restored the load distribution to a value closer to that of the normal knee joint, the experi- ment was performed only at 45° of knee flexion [ 15]a n d" 963 1477 W3014360692.pdf 1 7 separator 0.9941436 ¶ 1477 1479 W3014360692.pdf 1 8 caption 0.99267375 "Fig. 1 Experimental settings. aSchematic diagram for cut line of the femur and tibia. bAngle changing device set at 45°. cIntact porcine knees viewed laterally, set at 30°, 45°, 60°,and 90° flexion. dScheme for extrusion and centralization. LM, lateral meniscus; MM, medial meniscusKubota et al." 1479 1777 W3014360692.pdf 1 9 paratext 0.92532676 BMC Musculoskeletal Disorders (2020) 21:205 Page 2 of 8 1777 1842 W3014360692.pdf 1 0 title 0.98533165 Herbranson Change blindness in pigeons 0 38 W1678700176.pdf 1 1 separator 0.93655837 ¶ 38 40 W1678700176.pdf 1 2 text 0.99969864 "example of change blindness has been provided by Simons and Levin(1998).Anexperimenterstoppedunsuspectingindividuals on a college campus to ask for directions. During the ensuing conversation, two confederates carrying a door walked between the two conversants, and during the brief visual interruption the experimenter was replaced by a different person. About half of their participants didnotnotice thechangeintheir conversation partner. Surprisingly, change blindness can occur even when an individual is looking directly at the location of the change, and whenaparticipantisexpectingandactivelysearchingforchanges (seeSimonsandAmbinder,2005 )." 40 708 W1678700176.pdf 1 3 separator 0.9291022 ¶ 708 710 W1678700176.pdf 1 4 text 0.99972695 "Change blindness, of course, can occur under a variety of circumstances and with a diverse range of stimuli. A convenient way of studying change blind ness in the laboratory is the “flicker task,” developedby Rensink etal. (1997).Theypresented participants with two continuou sly alternating images, with consecutive presentations separated by a brief, blank inter-stimulus interval (ISI). The images were identical with the exception of a single feature, and participants were instructed to search for the difference as they alternated. Participants had difficultyfindingevenlargechanges,andnormallyrequiredmany repetitions before eventual successful identification. In contrast, whenthesameimageswerepresentedwithouttheISI,thechange was immediately apparent. Thus, the timing of a change has a powerful influence over whether or not it will be detected. The differenceinchangedetectionbetweentrialswithandwithoutan ISI provides a convenient and specific operational definition of change blindness, and underscores the importance of timing in changedetection." 710 1793 W1678700176.pdf 1 5 separator 0.9569216 ¶ 1793 1795 W1678700176.pdf 1 6 text 0.999767 "One of the appealing features of the flicker task is that it can be implemented in a laboratory setting, and Herbranson et al.(2014) developed a variation of the task to investigate a possible change blindness effect in pigeons. They presented pigeons with stimulusdisplays consisting ofrandomly generated lines across three response keys. As in other versions of the flicker task, alternating displays were identical except for onefeature (a single line that was present in one display but absent in the other), and pecks to the location of the change were reinforced at the end of a trial. Pigeons displayed the expected change blindness effect, in that accuracy was better on trials with no ISI than on trials with an ISI between consecutive displays. Their results also sho wed some other complex patterns reflecting the importance of time. In particular, the duration of the ISI had a powerful influence over the magnitude of the change blindness effect. As the ISI was shortened, accuracy on ISI trials rose toward the higher accuracy of no-ISI trials." 1795 2877 W1678700176.pdf 1 7 separator 0.9584853 ¶ 2877 2879 W1678700176.pdf 1 8 text 0.9997254 "In addition, pigeons showed evidence of using a serial search strategy over time. As the number of repetitions of the change increased,accuracyalsoincreased,asdidtheeffectivesearcharea." 2879 3068 W1678700176.pdf 1 9 separator 0.76826966 ¶ 3068 3070 W1678700176.pdf 1 10 text 0.99970794 "With few repetitions, pigeons produced overall low accuracy, and could reliably detect chan ges appearing on only two of the three response keys. With more repetitions, accuracy was higher overall, and better than chance on each of the three response keys." 3070 3335 W1678700176.pdf 1 11 separator 0.90659976 ¶ 3335 3337 W1678700176.pdf 1 12 text 0.99974924 "Pigeons from Herbranson et al. (2014) showed accuracy that was above chance, but not always particularly high (especially on trials that featured an ISI). Nevertheless, some aspects of theprocedureincreasedoverallaccuracybysystematicallyincreasing accuracy on the more difficult ISI trials: number of repetitions, and ISI duration. It is likely that there are numerous other factors thatwould similarly influence changedetection accuracy." 3337 3783 W1678700176.pdf 1 13 separator 0.9871763 ¶ 3783 3785 W1678700176.pdf 1 14 text 0.9996891 "Another plausible way to improve performance is to manipulate the salience of the displayed change. Smilek et al. (2000)u s e d a flicker paradigm with alternating displays consisting of arrays of block characters. As is usually the case, one character differed between displays, and the change was characterized as either large or small, depending on the number of line features that differed. For example, a change of a character from F to L (three features) was considered a large change, whereas a change from F to E (one feature) was a small change. Their human participants were faster to detect changes involving more features than they were to detect changes involving fewer features." 3785 4497 W1678700176.pdf 1 15 separator 0.9657021 ¶ 4497 4499 W1678700176.pdf 1 16 text 0.9985902 "In the modified pigeon version of the flicker task developed byHerbranson et al. ( 2014) ,t h ep o s s i b l ec h a n g el o c a t i o n sa r e limited and fixed, corresponding to the three keys in an operant chamber.A changein anyspatial location (i.e., on anyparticular key) is therefore likely to be rough ly as salient as any other: they are the same size, brightness, color, and pecking on each has been reinforced with approximately equal frequency. However, the discrete stimulus features (lines) do permit one to make a change more prominent using the same logic as Smilek et al. (2000): by increasing the number of line features that constitute a change. Whereas Herbranson et al. (2014)p r e s e n t e dt w o successive displays that differed by a single line feature on one key, the procedure is not limite d to changes involving a single feature; up to eight changes (all of the possible line features) can bemadetochangeonasinglekey.Adifferenceofasinglefeature on a key would presumably be a smaller or more subtle change than a difference involving multiple features. As the number of changesincreases,onewouldexpectchangedetectiontobecome proportionally easier, producing better accuracy, and requiring fewerrepetitions." 4499 5769 W1678700176.pdf 1 17 separator 0.99577713 ¶ 5769 5771 W1678700176.pdf 1 18 title 0.99005437 Materials and Methods 5771 5793 W1678700176.pdf 1 19 separator 0.99479294 ¶ 5793 5795 W1678700176.pdf 1 20 title 0.91423213 Animals 5795 5803 W1678700176.pdf 1 21 separator 0.9851125 ¶ 5803 5805 W1678700176.pdf 1 22 text 0.9995455 "Four White Carneaux Pigeons ( Columba livia ) were purchased from Double-T Farm (Glenwood, IA, USA). Each bird was fed mixed grain and maintained at 80–85% of free-feeding weight to approximate the condition of healthy wild birds ( Poling et al., 1990 ). Birds were housed in individual cages in a colony room with a 14:10-h light: dark cycle and had free access to water and grit. All four had previous experiences with a serial response time task ( Herbranson and Stanton, 2011 )a n d a change detection task ( Herbranson et al., 2014 ). Animal care and all procedures described below were approved by Whitman College’sInstitutional AnimalCareandUseCommittee." 5805 6487 W1678700176.pdf 1 23 separator 0.9967401 ¶ 6487 6489 W1678700176.pdf 1 24 title 0.9686403 Apparatus 6489 6499 W1678700176.pdf 1 25 separator 0.99360156 ¶ 6499 6501 W1678700176.pdf 1 26 text 0.9978074 "Four identical BRS/LVE operant chambers were used. Each had three circular response keys (2.5 cm in diameter) located in a horizontal row on the center of the front walland a food hopper" 6501 6692 W1678700176.pdf 1 27 separator 0.99070454 ¶ 6692 6694 W1678700176.pdf 1 28 paratext 0.9861155 Frontiers in Psychology | www.frontiersin.org 2 August 2015 | Volume 6 | Article 1109 6694 6780 W1678700176.pdf 1 0 paratext 0.9788137 "1 Vol.:(0123456789) Scientific Reports | (2022) 12:5498 | https://doi.org/10.1038/s41598-022-09552-8 www.nature.com/scientificreports" 0 147 W4220725360.pdf 0 1 title 0.9720591 "Association between chronic rhinosinusitis and pneumonia: a longitudinal follow‐up study using a national health screening cohort" 147 288 W4220725360.pdf 0 2 separator 0.99272156 ¶ 288 290 W4220725360.pdf 0 3 contact 0.58271444 "Jee Hye Wee1, Chanyang Min2,3, Hahn Jin Jung4, Min Woo Park5, Bumjung Park1 & Hyo Geun Choi1,2*" 290 389 W4220725360.pdf 0 4 separator 0.9939228 ¶ 389 391 W4220725360.pdf 0 5 text 0.99829507 "This study was aimed to compare the risk of pneumonia between patients with chronic rhinosinusitis (CRS) and those without CRS (control) in a Korean population. The population aged 40 years or over was included from the Korean National Health Insurance Service‐Health Screening Cohort." 391 683 W4220725360.pdf 0 6 separator 0.9627873 ¶ 684 686 W4220725360.pdf 0 7 text 0.99930036 "Participants with CRS (n = 6393) and controls (n = 25,572) were selected by 1:4 matching for age, sex, income, region of residence, and history of pneumonia for the previous 1 year. The index date (ID) of the controls was set as the treatment date of their matched CRS participants. The incidence of pneumonia after the ID was measured from 2003 to 2015. Simple and multiple linear regressions were performed to calculate estimated values (EVs) and 95% confidence intervals (CIs) for 1‐y post ‐ID pneumonia, 2‐y post ‐ID pneumonia, and 3‐y post ‐ID pneumonia in CRS participants compared to controls. Statistical significance was noted in the 3‐y post ‐ID period (EV = 0.017, 95% CI = 0.002–0.031, P = 0.030). In the subgroup analyses according to age and sex, statistical significance was seen in the younger age group (< 60 years old) in the 3‐y post ‐ID period and in the female group in the 1‐y and 3‐y post ‐ID periods. This study revealed an increased risk for pneumonia following a diagnosis of CRS." 686 1720 W4220725360.pdf 0 8 separator 0.98798984 ¶ 1720 1722 W4220725360.pdf 0 9 text 0.9979021 "Pneumonia is a form of acute respiratory infection caused by viruses, bacteria, and fungi and a major cause of morbidity and mortality globally. According to the World Health Organization (WHO)’s 2019 Global Health Estimates, pneumonia and other lower respiratory infections were ranked as the fourth leading cause of death and disability-adjusted life years1. In Korea, deaths due to pneumonia have continued to increase since 2000, and in 2019, the death rate for pneumonia stood at 45.1 per 100,000 population, ranking as the third leading cause of deaths2. In a recent study in Korea, the hospitalization rate due to bacterial pneumonia was reported to be 161.5 per 10,000 population over the age of 653. Several risk factors, such as diabetes, cardiovascular disease, smoking, asthma, and chronic obstructive pulmonary disease (COPD), have been shown to increase the likeli- hood of the development of pneumonia4." 1722 2668 W4220725360.pdf 0 10 separator 0.9730821 ¶ 2668 2670 W4220725360.pdf 0 11 text 0.9997081 "Chronic rhinosinusitis (CRS) is a chronic upper airway inflammation that can greatly influence the health- related quality of life of patients and the socioeconomic burden5. Several epidemiological studies have shown that CRS is associated with lower airway diseases such as asthma6, bronchiectasis7, and COPD8. This interdependence of the upper and lower respiratory tracts has led to the concept of the “unified airway” , which considers the upper and lower airways to be a single functional unit9." 2670 3187 W4220725360.pdf 0 12 separator 0.96908903 ¶ 3187 3189 W4220725360.pdf 0 13 text 0.9996938 "Despite the correlations between the upper and lower airways, few studies have evaluated the association of CRS and pneumonia. A retrospective study using X-ray findings reported that the frequency of sinusitis was found to be 84% among patients with pneumonia10. A previous study in the U.S. showed an association between OPEN" 3189 3524 W4220725360.pdf 0 14 separator 0.99482757 ¶ 3524 3526 W4220725360.pdf 0 15 contact 0.99159074 "1Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170-beon-gil, Dongan-gu, Anyang, Gyeonggi-do 14068, Korea. 2Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea. 3Graduate School of Public Health, Seoul National University, Seoul, Korea. 4Department of Otorhinolaryngology-Head & Neck Surgery, Chungbuk National University College of Medicine, Chungbuk National University Hospital, Cheongju, Korea. 5Department of Otorhinolaryngology-Head & Neck Surgery, Kangdong Sacred Heart Hospital, Seoul, Korea. *email: pupen@naver.com" 3526 4208 W4220725360.pdf 0 0 paratext 0.54268193 Pattern Recognition Receptors Based ¶ 0 39 W1529123995.pdf 21 1 title 0.92537856 Immune Adjuvants: Their Role and Importance in Vaccine Design 39 101 W1529123995.pdf 21 2 separator 0.6956205 102 103 W1529123995.pdf 21 3 paratext 0.7145736 ¶ 197 103 109 W1529123995.pdf 21 4 separator 0.9867033 ¶ 110 112 W1529123995.pdf 21 5 title 0.93223447 Target TLR antagonists I ndication Status (Company) 112 164 W1529123995.pdf 21 6 table 0.7211742 "¶ TLR4 TAK-242 Severe sepsis P-III (TPC) E5564 or Eritoran: a lipid A derivative Severe sepsis P-III (E) TLR7 and TLR 9 Immunoregulatory sequence IRS 954 Lupus Preclinical (DT)" 165 378 W1529123995.pdf 21 7 separator 0.9460208 ¶ 379 381 W1529123995.pdf 21 8 contact 0.691933 Full name of developing company/institutes: TPC – Takeda Pharmaceutical Company; E- Eisai. 381 472 W1529123995.pdf 21 9 separator 0.9966372 ¶ 473 475 W1529123995.pdf 21 10 title 0.9762183 "Table 5. TLR antagonists in clinical develo pment for anti-inflammatory and auto-immune diseases" 475 575 W1529123995.pdf 21 11 separator 0.9958537 ¶ 576 578 W1529123995.pdf 21 12 title 0.99357367 8. Role of adjuvants in the immune responses 578 623 W1529123995.pdf 21 13 separator 0.9955411 ¶ 624 626 W1529123995.pdf 21 14 text 0.99420226 "Precisely, how adjuvants enhance the immune re sponse is yet unknown, but they appear to exert different effects to improve the immune response to vaccine antigens, as such they: i. Immunomodulation - This refers to the ability of adjuvants to activate the immune response either to Th1 or Th2. ii. Targeting - Improve antigen delivery to antigen pres enting cells (APCs), increase cellular infiltration, inflammation, and tr afficking to the injection site. iii. Activation of APCs by up-regulating co-stimulatory signals, major histo-compatibility complexes (MHC) expression and inducing cytokine release. iv. Antigen Presentation - Enhance antigen processing an d presentation by APCs and increase the speed, magnitude and du ration of the immune response." 626 1413 W1529123995.pdf 21 15 separator 0.7710357 ¶ 1414 1416 W1529123995.pdf 21 16 text 0.9787096 "v. Antigen Depot formation vi. Induction of antibody -modulation of antibody avidity, a ffinity as well as the magnitude, isotype or subclass induction. vii. Stimulate cell mediated immunity and lymphocyte proliferation nonspecifically." 1416 1663 W1529123995.pdf 21 17 separator 0.996619 ¶ 1664 1666 W1529123995.pdf 21 18 title 0.9933421 9. Characteristics of an ideal adjuvant 1666 1706 W1529123995.pdf 21 19 separator 0.99620193 ¶ 1707 1709 W1529123995.pdf 21 20 text 0.99729717 "It is likely that the “ideal” adjuvant does not and will not exist, because each adjuvant and its targeted antigen will have their unique requirements. Nevertheless, the generic characteristics summarized below would be desirable. To date , no adjuvant meets all of these goals. i. It must be safe, including freedom from immediate and long-term side effects. ii. It should be biodegradable or easily removed from the body after its adjuvant effect is exhausted to decrease the risk of late adverse effects. iii. I t s h o u l d e l i c i t a m o r e r o b u s t p r o t e c t i v e or therapeutic immune response combined with the antigen than when the antigen is administered alone. iv. It must be defined chemically and biologically, so that there is no lot-to-lot variation in the manufactured product, thereby assuring consistent responses in vaccines between studies and over time. v. Efficacy should be achieved using fewer doses and/or lower concentrations of the antigen." 1709 2734 W1529123995.pdf 21 21 separator 0.94741094 ¶ 2735 2737 W1529123995.pdf 21 22 text 0.9404694 www.intechopen.com 2737 2756 W1529123995.pdf 21 0 paratext 0.9861434 RESEARCH ARTICLE Open Access 0 28 W2115066965.pdf 0 1 separator 0.94717556 ¶ 28 30 W2115066965.pdf 0 2 title 0.98521215 "Temporal trends (1977-2007) and ethnic inequity in child mortality in rural villages of southernGuinea Bissau" 30 142 W2115066965.pdf 0 3 separator 0.96870816 ¶ 142 144 W2115066965.pdf 0 4 paratext 0.5395749 Il 144 147 W2115066965.pdf 0 5 contact 0.5130051 a Fazzio 147 155 W2115066965.pdf 0 6 paratext 0.4816379 1, 155 157 W2115066965.pdf 0 7 contact 0.5106888 Vera Mann 157 167 W2115066965.pdf 0 8 paratext 0.5130647 2*and 167 172 W2115066965.pdf 0 9 contact 0.46807936 Peter Boone 172 184 W2115066965.pdf 0 10 paratext 0.62343323 1 184 185 W2115066965.pdf 0 11 separator 0.98980236 ¶ 185 187 W2115066965.pdf 0 12 title 0.94382787 Abstract 187 196 W2115066965.pdf 0 13 separator 0.9930607 ¶ 196 198 W2115066965.pdf 0 14 text 0.999268 "Background: Guinea Bissau is one of the poorest countries in the world, with one of the highest under-5 mortality rate. Despite its importance for policy planning, data on child mortality are often not available or of poor quality in low-income countries like Guinea Bissau. Our aim in this study was to use the baseline survey to estimate childmortality in rural villages in southern Guinea Bissau for a 30 years period prior to a planned cluster randomisedintervention. We aimed to investigate temporal trends with emphasis on historical events and the effect ofethnicity, polygyny and distance to the health centre on child mortality." 198 840 W2115066965.pdf 0 15 separator 0.98150885 ¶ 840 842 W2115066965.pdf 0 16 text 0.99913013 "Methods: A baseline survey was conducted prior to a planned cluster randomised intervention to estimate child mortality in 241 rural villages in southern Guinea Bissau between 1977 and 2007. Crude child mortality rates were estimated by Kaplan-Meier method from birth history of 7854 women. Cox regression models were used toinvestigate the effects of birth periods with emphasis on historical events, ethnicity, polygyny and distance to thehealth centre on child mortality." 842 1321 W2115066965.pdf 0 17 separator 0.9793289 ¶ 1321 1323 W2115066965.pdf 0 18 text 0.9993696 "Results: High levels of child mortality were found at all ages under five with a significant reduction in child mortality over the time periods of birth except for 1997-2001. That period comprises the 1998/99 civil war interval, when child mortality was 1.5% higher than in the previous period. Children of Balanta ethnic group had higherhazard of dying under five years of age than children from other groups until 2001. Between 2002 and 2007, Fulachildren showed the highest mortality. Increasing walking distance to the nearest health centre increased thehazard, though not substantially, and polygyny had a negligible and statistically not significant effect on thehazard." 1323 2004 W2115066965.pdf 0 19 separator 0.8897063 ¶ 2004 2006 W2115066965.pdf 0 20 text 0.99935186 "Conclusion: Child mortality is strongly associated with ethnicity and it should be considered in health policy planning. Child mortality, though considerably decreased during the past 30 years, remains high in rural Guinea Bissau. Temporal trends also suggest that civil wars have detrimental effects on child mortality." 2006 2331 W2115066965.pdf 0 21 separator 0.9898145 ¶ 2331 2333 W2115066965.pdf 0 22 text 0.4208229 2333 2334 W2115066965.pdf 0 23 paratext 0.5005287 Trial 2334 2339 W2115066965.pdf 0 24 text 0.4186766 2339 2340 W2115066965.pdf 0 25 paratext 0.40246737 Registration 2340 2352 W2115066965.pdf 0 26 text 0.49694315 : Current Controlled Trials ISRCTN52433336 2352 2394 W2115066965.pdf 0 27 separator 0.9964954 ¶ 2394 2396 W2115066965.pdf 0 28 title 0.9287788 Background 2396 2407 W2115066965.pdf 0 29 separator 0.9944227 ¶ 2407 2409 W2115066965.pdf 0 30 text 0.9994306 "Although overall rates of child mortality have been dropping steadily in the last 50 years, these declineshave not been homogeneous across different regionsand countries. Sub-Saharan Africa still has the highestlevels of child mortality in the world, accounting for 49.6% of child deaths in 2010 [1], with a decline that isconsidered slow and insufficient to achieve the Millen- nium Development Goal 4 in many countries [1-5].West and Central Africa show the worst rate ofimprovement in child survival, with only 18% progressbetween 1990 and 2008 [2]. Africa is also characterizedby a wide variation in mortality levels that has not nar- rowed since the late 1950s. In the late 1950s, under-five mortality ranged from 113 to 381 deaths per 1000 livebirths (Mauritius and Sierra Leone), by the late 1990sthis gap became even wider from 21 to 334 deaths per1000 live births (Mauritius and Niger) [3]. In 2009" 2409 3327 W2115066965.pdf 0 31 separator 0.98644507 ¶ 3327 3329 W2115066965.pdf 0 32 contact 0.9800964 "* Correspondence: Vera.Mann@lshtm.ac.uk 2Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK" 3329 3473 W2115066965.pdf 0 33 separator 0.8517678 ¶ 3473 3475 W2115066965.pdf 0 34 paratext 0.9573967 "Full list of author information is available at the end of the articleFazzio et al .BMC Public Health 2011, 11:683 http://www.biomedcentral.com/1471-2458/11/683" 3475 3638 W2115066965.pdf 0 35 separator 0.6299716 ¶ 3638 3640 W2115066965.pdf 0 36 paratext 0.9727797 "© 2011 Fazzio et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited." 3640 3967 W2115066965.pdf 0 0 paratext 0.98866105 Int. J. Mol. Sci. 2019 ,20, 504 15 of 20 0 40 W2912455480.pdf 14 1 separator 0.6650369 ¶ 40 42 W2912455480.pdf 14 2 paratext 0.9853952 Int. J. Mol. Sci. 2018 , 19, x FOR PEER REVIEW 15 of 20 42 99 W2912455480.pdf 14 3 separator 0.99347186 ¶ 100 102 W2912455480.pdf 14 4 text 0.996163 "In literature, some samples prepared by the PEG method were studied, an d it was noticed that some short fiber clusters are entangled with PLA ma trix with a not evident phase separation between CNs and PLA. This observation revealed that PEG is a good interfacial compatibilizer for CNs and PLA. However, this reinforcing effect may be weak ened due to a decrement of the CN aspect ratio. " 103 504 W2912455480.pdf 14 5 separator 0.52714866 ¶ 504 505 W2912455480.pdf 14 6 text 0.99902415 "These aspects would require further research to better understand the effect of structural and morphologic parameters on the final properties." 505 651 W2912455480.pdf 14 7 separator 0.97784334 ¶ ¶ 652 658 W2912455480.pdf 14 8 caption 0.99635994 "Figure 13. Tensile results as a function of PEG400 cont ent at constant CN concentration (2% by weight): ( a) Young’s Modulus E; ( b) Stress at yield σy; (c) stress at break σb; (d) elongation at break εb." 658 867 W2912455480.pdf 14 9 separator 0.9961276 ¶ 868 870 W2912455480.pdf 14 10 title 0.99299705 4. Materials and Methods 870 895 W2912455480.pdf 14 11 separator 0.9964447 ¶ 896 898 W2912455480.pdf 14 12 title 0.9409815 4.1. Materials 898 913 W2912455480.pdf 14 13 separator 0.99299884 ¶ 914 916 W2912455480.pdf 14 14 text 0.9996127 "Chitin nanofibrils (CN) water suspension at a concentration of 2% wt. was produced by MAVI SUD through its patented process [56], starting fr om chitin coming from seafood waste. For the preparation of the pre-composites, it was concentrated at 20% by weight." 916 1182 W2912455480.pdf 14 15 separator 0.6931634 ¶ 1183 1185 W2912455480.pdf 14 16 text 0.9996051 "Poly(ethylene glycol) (PEG), a liquid having a molecular weight of 400 (low), and PEG, a solid having a molecular weight of 1500, 4000, 6000 an d 8000 (high), were purchased from Aldrich and used without any further purification." 1185 1421 W2912455480.pdf 14 17 separator 0.7808174 ¶ 1422 1424 W2912455480.pdf 14 18 text 0.99940103 "PLA IngeoTM 2003D, Extrusion Gr ade with density of 1.24 g/cm3, a melt index of 6 g/10 min at 210 °C and 2.16 Kg, produced by NatureWorks LLC. It has a molecular weight of 170,000 g/mol and contains up to 4.1% isomeric D unit s. It was dried in ventilated oven at 60 °C for 16 h before extrusion trials." 1424 1736 W2912455480.pdf 14 19 separator 0.9969082 ¶ 1737 1739 W2912455480.pdf 14 20 title 0.99236876 4.2. Materials Preparation 1739 1766 W2912455480.pdf 14 21 separator 0.9955205 ¶ 1767 1769 W2912455480.pdf 14 22 text 0.9995846 "PEG400 (or PEG800) were added to concentrated chitin nanofibrils suspension and stirred for two hours at room temperature. The amount wa s calculated considering that in the final pre- composites, the weight ratio of CN and PEG was 1: 1. The obtained semiliquid emulsion was dried in a ventilated oven at 50 °C up to constant weight to obtain a solid when PEG8000, PEG6000, PEG4000" 1769 2160 W2912455480.pdf 14 23 separator 0.9928752 ¶ 2161 2163 W2912455480.pdf 14 24 caption 0.99647015 "Figure 13. Tensile results as a function of PEG400 content at constant CN concentration (2% by weight): (a) Young’s Modulus E; ( b) Stress at yield y; (c) stress at break b; (d) elongation at break ""b." 2163 2369 W2912455480.pdf 14 25 separator 0.9837883 ¶ 2369 2371 W2912455480.pdf 14 26 text 0.9939275 "In literature, some samples prepared by the PEG method were studied, and it was noticed that some short fiber clusters are entangled with PLA matrix with a not evident phase separation between CNs and PLA. This observation revealed that PEG is a good interfacial compatibilizer for CNs and PLA. " 2371 2670 W2912455480.pdf 14 27 separator 0.59430397 ¶ 2670 2671 W2912455480.pdf 14 28 text 0.9992909 "However, this reinforcing effect may be weakened due to a decrement of the CN aspect ratio. These aspects would require further research to better understand the effect of structural and morphologic parameters on the final properties." 2671 2909 W2912455480.pdf 14 29 separator 0.9968594 ¶ 2909 2911 W2912455480.pdf 14 30 title 0.9922403 4. Materials and Methods 2911 2936 W2912455480.pdf 14 31 separator 0.99588853 ¶ 2936 2938 W2912455480.pdf 14 32 title 0.7858866 4.1. Materials 2938 2953 W2912455480.pdf 14 33 separator 0.980466 ¶ 2953 2955 W2912455480.pdf 14 34 text 0.9994413 "Chitin nanofibrils (CN) water suspension at a concentration of 2% wt. was produced by MAVI SUD through its patented process [ 56], starting from chitin coming from seafood waste. For the preparation of the pre-composites, it was concentrated at 20% by weight." 2955 3218 W2912455480.pdf 14 35 separator 0.6924082 ¶ 3218 3220 W2912455480.pdf 14 36 text 0.99942464 "Poly(ethylene glycol) (PEG), a liquid having a molecular weight of 400 (low), and PEG, a solid having a molecular weight of 1500, 4000, 6000 and 8000 (high), were purchased from Aldrich and used without any further purification." 3220 3452 W2912455480.pdf 14 37 separator 0.73841804 ¶ 3452 3454 W2912455480.pdf 14 38 text 0.9985949 "PLA Ingeo TM2003D, Extrusion Grade with density of 1.24 g/cm3, a melt index of 6 g/10 min at 210C and 2.16 Kg, produced by NatureWorks LLC. It has a molecular weight of 170,000 g/mol and contains up to 4.1% isomeric D units. It was dried in ventilated oven at 60C for 16 h before extrusion trials." 3454 3759 W2912455480.pdf 14 39 separator 0.9968606 ¶ 3759 3761 W2912455480.pdf 14 40 title 0.990457 4.2. Materials Preparation 3761 3788 W2912455480.pdf 14 41 separator 0.9956293 ¶ 3788 3790 W2912455480.pdf 14 42 text 0.99955904 "PEG400 (or PEG800) were added to concentrated chitin nanofibrils suspension and stirred for two hours at room temperature. The amount was calculated considering that in the final pre-composites, the weight ratio of CN and PEG was 1:1. The obtained semiliquid emulsion was dried in a ventilated oven at 50C up to constant weight to obtain a solid when PEG8000, PEG6000, PEG4000 and PEG1500 were used, and a sample with liquid highly viscous consistency when PEG 400 was used." 3790 4272 W2912455480.pdf 14 0 paratext 0.9768626 "International Journal of Clinical Case Reports and Reviews. Copy rights@ Liliya Pekova et all. ¶ Aucto res Publishing LLC – Volume 1 6(3)-378 www.auctoresonline.org ISSN : 2690 -4861 Page 3 of 5" 0 448 W4395054868.pdf 2 1 separator 0.99637365 ¶ 450 452 W4395054868.pdf 2 2 caption 0.981241 Figure 1: Spectrum of clinical manifestations in CDI 452 505 W4395054868.pdf 2 3 separator 0.9896158 ¶ 507 509 W4395054868.pdf 2 4 title 0.9840363 Discussion 509 520 W4395054868.pdf 2 5 separator 0.99173653 ¶ 522 524 W4395054868.pdf 2 6 text 0.9997294 "The Covid -19 pandemic significantly impacted the healthcare systems worldwide. Now more than ever some open questions concerning CDAD need to be discussed. CD is a multi -resistant pathogen recognized as a leading cause of diarrhea associated with antibioti c treatment [11]. Age is considered one of the primary risk factors of CDI in general and especially for severe forms. Keller MJ at al. found that patients over the age of 65 were 10 times more likely to contract CD as younger in -patients in the same facil ity [12]. The mean age of our patients was 69,64±12,2 which corresponded to the statement that the elderly are more prone to CDI. It has been established that female are 1,5 times more likely than male to have CDI [13]. In our research, men have a slight p reponderance - 56.19%. Diarrhea was the main symptom of all the patients of the studied cohort – profuse watery stools, which may be mixed more often with mucus than with blood. Diarrhea with such characteristics is described in the scientific literature a s a cardinal symptom of CDI [14]. We registered mucus in 52,2% and blood in 15,7% of the cases. Most patients developed diarrhea during or shortly after starting antibiotics. Some individuals may not show symptoms for up to 8 weeks after completing therapy [15]." 524 1870 W4395054868.pdf 2 7 separator 0.9704656 ¶ 1871 1873 W4395054868.pdf 2 8 text 0.99973315 "Patients who develop mild to moderate CDI commonly present with 3 or up to 10 loose stools in 24 hours. Mild abdominal pain, nausea and low - grade fever may be another symptom [16]. We registered such clinical manifestations in 33% of the cases. Cli nical manifestations of severe form include profuse watery mucoid diarrhea as often as 10 to 15 times a day, dehydration, hypotension rapid heart rate, abdominal pain that may be severe. Fever up to 40 ̊C and WBC up to 50.109/L are markers for severe forms. Criteria proposed for severe CDI (based on expert opinion) include WBC count ≥15. 109/L and serum creatinine >133 mmol/L [17]." 1873 2533 W4395054868.pdf 2 9 separator 0.9511347 ¶ 2534 2536 W4395054868.pdf 2 10 text 0.9996786 "High levels of CRP, hypoproteinemia and hypoalbuminemia are another marker of severity [16]. 32,2% of our patients developed sev ere CDI." 2536 2677 W4395054868.pdf 2 11 separator 0.86396027 ¶ 2678 2680 W4395054868.pdf 2 12 text 0.99964195 "Fever up to 39,4 ̊C and elevated WBC count to 29,4.109/L were indicators for severity in our study. Protein -losing enteropathy with hypoalbuminemia may develop within the first days of clinical presentation of CDI [18]. We registered hypoalbuminemi a in 82 patients (67,8%) resulting in peripheral edema. Three patients (2,48%) developed anasarca. All the patients of the studied cohort received massive antibiotic treatment for SARS -CoV -2 infection before admission, during hospitalization and after disc harge. The median duration of antibiotic use was 26,7±9,47 days." 2680 3277 W4395054868.pdf 2 13 separator 0.9607673 ¶ 3279 3281 W4395054868.pdf 2 14 text 0.9846715 "The antibiotic most frequently prescribed were cephalosporines second and third generation, fluoroquinolones, macrolides, and aminoglicosides. Some patients had concomitant therapy with two or three antibiotics." 3281 3499 W4395054868.pdf 2 15 separator 0.76307476 ¶ 3501 3503 W4395054868.pdf 2 16 text 0.999745 "According to Rowson et al. 72% of the hospi talized patients with Covid - 19 were treated with broad -spectrum antibiotics but only 8% had confirmed bacterial/fungal coinfection [19]. Our patients developed diarrhea as the main symptom of CDI within 10 to 60 days (8±7.38) days after the diagnosis of Co vid-19, which coincides with the interval of 21 days reported in the scientific literature [20]. Severe CDI may be complicated with ascites, acute respiratory distress, toxic megacolon, acute heart failure, acute renal failure, liver abscessus, septic sh ock, cardiac arrest. Some patients may develop mental disorders [21]. Granata et al. reports for 28,9% severe cases with complications in their studies [14]. In our study those cases were in 11,57%. There was a lethal outcome in 12 patients (9,91%). The other patients were discharged with improvement. In recent years there is an increased global burden of CDI associated with increased morbidity and mortality. According to many studies hyper virulent clone of CD - ribotype 027 is associated with a great number of severe and fulminant cases [22]. Ribotypes were not detected in our study, so we could not associate the severity and the outcomes of CDIs with any ribotype. The diagnosis was based on clinical presentation suspectable for CDI and confirmed by dete ction of CD toxin in stool samples. Covid -19 can present with gastrointestinal symptoms similar to CDI, making it appropriate to consider both conditions in a patient with diarrhea. SARS -CoV -2 alters gut microbiota and discussed as a possible risk factor f or CDI commensurate with overuse of antibiotics [23]." 3503 5209 W4395054868.pdf 2 17 separator 0.98311603 ¶ 5211 5213 W4395054868.pdf 2 18 text 0.99971855 "Candida albicans was detected in stool samples of 22 our patients (18,2%) with confirmed CDI. Antibiotics are mainstay to treat CDI. Treatment strategies should be based on disease severity, reccurence risk and comorbidities. Vancomycin is recommended for severe and complicated CDI. Methronidazole is recommended for mild to moderate disease. Both may be used in combination to treat severe CDI [24]. We applied treatment of CDI according to the cited gene rally accepted recommendations. Fecal microbiota transplant is a treatment for multiple recurrent CDI but its role in primary and severe CDI is not established [25]. Recently CDI increases and become less responsive to treatment [26] Relapses occurred in 9 (7,43%) of our patients within 12 to 22 days, (10±7,82) after dischargment. This percentage is lower than that reported in the literature - 15-20% [27]. The hospital stay was 10±4.73 days, which is consistent with the data published so far [28]. We found a correlation between length of hospital stay and fatal outcome. Cramer's correlation coefficient was used: Cramer's V=0.418, p=0.002. The relationship between the variables was checked by χ2 test and was statistically significant with p=0.003. However, w e did not find such a relationship between the hospital stay and the severity of the clinical form of the disease, as well as between Clostridium difficile toxins and the outcome of the disease." 5213 6697 W4395054868.pdf 2 19 separator 0.98226094 ¶ 6699 6701 W4395054868.pdf 2 20 text 0.99962634 "The identified risk factors for development of CDI correspond to the published data for the general population – overuse of broad -spectrum antibiotics, geriatric population, patients with suppressed immune system, comorbidities, delayed diagnose and admiss ion in hospital. There is no correlation between the duration of antibiotic treatment, the patient age and the severity of CDI [29]." 6701 7107 W4395054868.pdf 2 21 separator 0.9961195 ¶ 7109 7111 W4395054868.pdf 2 0 paratext 0.9756218 "5 Vol.:(0123456789) Scientific Reports | (2023) 13:11320 | https://doi.org/10.1038/s41598-023-38411-3" 0 112 W4384129435.pdf 4 1 separator 0.9696349 ¶ 112 114 W4384129435.pdf 4 2 text 0.9794686 "www.nature.com/scientificreports/of CO formation in these conditions was ΓCO = 99.9%, with no H2 and negligible amount of HCOOH observed (see Fig. 2, right panel)." 114 282 W4384129435.pdf 4 3 separator 0.78600216 ¶ 282 284 W4384129435.pdf 4 4 text 0.99958926 "Ru2ReA. A procedure similar to that formerly described for RuRe2A was used to study the photocatalytic activity of Ru2ReA. 3 mL of a CO2-saturated solution of DMA-TEOA 5:1 v/v, containing Ru2ReA and BIH with a concentration of 24 μM and 0.1 M respectively—the concentration of Ru2ReA is roughly half concentration than that in the photocatalytic system using RuRe2A described above, to have the same light absorption, mainly due to the Ru-based subunits—was charged in several identical tubes. The solutions were irradiated by using the same LED light source (530 nm) used in the previous experiment, at room temperature. The photochemical reaction has been monitored for 20 h and a TONCO of 2695 has been calculated within this time, based on the amount of Ru2ReA used (Fig. 3, Table 1). The total CO production has been calculated to be 1.9 × 10–4 mol, to be compared with 3 × 10–4 mol of BIH starting amount. From such data we can state that ca. the 60% of the BIH initially present in solution was consumed after 20 h of irradiation. However, in this case the CO formation con- tinued even after 20 h of irradiation (not shown), suggesting that the photocatalyst was still active. The calculated selectivity of CO formation (ΓCO) in the condition used was ca. 98.9% (Table 1), with small amount of H2 and HCOOH present in solution (Fig. 3, right panel)." 284 1685 W4384129435.pdf 4 5 separator 0.9731017 ¶ 1685 1687 W4384129435.pdf 4 6 text 0.9996313 "For both the studied complexes, the results can be considered a significative improvement if compared to the ones obtained in a precedent work (see data in Table 1)29 in which both in RuRe2 and Ru2Re species the Re(I) metal ion was coordinated by chloride ion instead of TEOA-CO2. Indeed, as far as RuRe2A is concern29ed, the selectivity and the TONCO values rises by ca. 8 and 21% respectively compared to RuRe2 complex, whereas for Ru2ReA the selectivity and the TONCO values rises by ca. 9 and 8%, respectively, compared to Ru2Re. For bet - ter comparison, the photocatalytic activity of the parent species RuRe2 and Ru2Re, already reported24, are also shown in Figs. 2 and 3 , respectively, under the identical experimental conditions." 1687 2450 W4384129435.pdf 4 7 separator 0.9936531 ¶ 2450 2452 W4384129435.pdf 4 8 text 0.9366464 Comparisons of the photocatalytic data shown in Table 1 and Figs. 2 and 3 suggest some considerations. 2452 2558 W4384129435.pdf 4 9 separator 0.92960525 ¶ 2559 2561 W4384129435.pdf 4 10 text 0.99931777 "First, RuRe2A and RuRe2 yield CO almost quantitatively, considering the maximum possible yield of CO on the basis of the sacrificial reagent which is present. Particularly, the CO photoproduction of RuRe2A is complete" 2561 2782 W4384129435.pdf 4 11 separator 0.95267427 ¶ 2783 2785 W4384129435.pdf 4 12 caption 0.9951051 "Figure 2. Left: Photocatalytic formation of CO concerning RuRe2A (blue line) compared to RuRe2 (red line) as a function of irradiation time (excitation wavelength, 530 nm). Both complexes are about 50 μM, in a CO2- saturated DMA–TEOA (5:1 v/v, 3 mL) solution containing BIH (0.1 M). Right: HCOOH produced." 2785 3098 W4384129435.pdf 4 13 separator 0.9924143 ¶ 3098 3100 W4384129435.pdf 4 14 title 0.6215136 Table 1. Photocatalytic properties of Ru2ReA and RuRe2A. The same properties of Ru2Re and 3100 3191 W4384129435.pdf 4 15 table 0.52216375 "RuRe2 are shown for comparison purposes. CO2-saturated DMA-TEOA (5:1 v/v" 3191 3267 W4384129435.pdf 4 16 text 0.439781 ), 3267 3269 W4384129435.pdf 4 17 table 0.48846874 "3 mL solutions containing the supramolecular photocatalysts and a BIH as the sacrificial electron donor (" 3269 3378 W4384129435.pdf 4 18 text 0.43859163 0.1 3378 3381 W4384129435.pdf 4 19 table 0.45171326 M 3381 3383 W4384129435.pdf 4 20 text 0.471861 ). Light 3383 3391 W4384129435.pdf 4 21 table 0.5581074 "irradiation wavelength, 530 nm. The concentration of the photocatalysts containing one Ru-based subunit was 50 μM, where" 3391 3518 W4384129435.pdf 4 22 text 0.44938862 as 3518 3520 W4384129435.pdf 4 23 table 0.5084207 the concentration of the photocatalysts containing two Ru-based subunits 3520 3593 W4384129435.pdf 4 24 text 0.47200426 "was 25 μM, unless otherwise state" 3593 3630 W4384129435.pdf 4 25 table 0.44154644 d 3630 3631 W4384129435.pdf 4 26 text 0.48138595 , to normalize for 3631 3649 W4384129435.pdf 4 27 table 0.46337038 light absorption in the 3649 3674 W4384129435.pdf 4 28 text 0.4456563 various experiment 3674 3692 W4384129435.pdf 4 29 table 0.47075742 s. 3692 3694 W4384129435.pdf 4 30 separator 0.638305 3694 3695 W4384129435.pdf 4 31 table 0.4872984 a 3695 3696 W4384129435.pdf 4 32 caption 0.884614 "In parenthesis, the percentage of CO production vs sacrificial reagent concentration is given; based on the concentration of the sacrificial donor, the theoretical maximum of CO photoproduced is 0.30 mmol. bTurnover numbers are based on the amount of photocatalyst. cConcentration of the photocatalyst was 44 μM. dData from ref.29." 3696 4036 W4384129435.pdf 4 33 table 0.9833841 "Photocatalyst Mmol CO produced (percentage of CO production)aTON (CO produced)bГCO RuRe2Ac0.30 (100%) 2368 99.9% Ru2ReA 0.19 (63%) 2695 98.9% RuRe2d0.28 (93%) 1850 98.8% Ru2Red0.18 (60%) 2486 90%" 4036 4239 W4384129435.pdf 4 0 text 0.99960685 "escalas ( Yang et al., 2000 , Wen e Chen, 2003). Nesta condição de cultivo a produção destes bioprodutos (ácidos graxos poliinsaturados, carotenóides, ficobilinas, polissacarídeos entre outros) é economicamente útil, dado reduções significativas na complexidade dos bioprocessos e dos custos operacionais ( Tuchman, 1996 ). Onde uma das razões é o consumo de fontes de carbono simples, barato e disponível como a glicose, acetato, glicerol, sacarose, entre outros." 0 480 W2249018887.pdf 1 1 separator 0.9733904 ¶ 482 484 W2249018887.pdf 1 2 text 0.999562 "O custo final da produtividade de biomassa é a característica essencial para os sistemas de cultivo e depende essencialmente das condições e do meio de cultivo (Borowitzka, 1992). Em vista disso uma alternativa para aumentar a redução deste custo é a utilização de sacarose como fonte de carbono orgânico, uma vez que a glicose, a principal fonte utilizada possui alto valor comercial. No entanto a ausência da invertase em algumas espécies de microalgas torna a hidrólise da sacarose uma etapa primordial para o desenvolvimento do processo (Perez-Garcia et al., 2011)." 485 1073 W2249018887.pdf 1 3 separator 0.99721044 ¶ 1075 1077 W2249018887.pdf 1 4 title 0.9903698 2. OBJETIVO 1077 1089 W2249018887.pdf 1 5 separator 0.9957653 ¶ 1091 1093 W2249018887.pdf 1 6 text 0.9987982 "O estudo teve como objetivo avaliar o cultivo heterotrófico da microalga Phormidium sp. utilizando sacarose hidrolisada como fonte de carbono orgânico em diferentes razões carbono/nitrogênio." 1094 1292 W2249018887.pdf 1 7 separator 0.99675155 ¶ 1293 1295 W2249018887.pdf 1 8 title 0.99306107 3. MATERIAIS E MÉTODOS 1295 1318 W2249018887.pdf 1 9 separator 0.99669826 ¶ 1320 1322 W2249018887.pdf 1 10 title 0.98482364 3.1. Microrganismo e condições de cultivo 1322 1365 W2249018887.pdf 1 11 separator 0.9924357 ¶ 1367 1369 W2249018887.pdf 1 12 text 0.9997031 "A cianobactéria utilizada foi a Phormidium sp., isolada do Deserto Cuatro Cienegas no México (26o59’N 102o03W). Após purificação, as culturas estoque foram mantidas em tubos de ensaio com meio sintético BGN (Rippka et al., 1979) solidificado com agar-agar. As condições de manutenção usadas foram 25oC e intensidade luminosa constante de 1klux." 1370 1724 W2249018887.pdf 1 13 separator 0.9971007 ¶ 1725 1727 W2249018887.pdf 1 14 title 0.99268216 3.2. Hidrólise da sacarose 1727 1754 W2249018887.pdf 1 15 separator 0.99555576 ¶ 1755 1757 W2249018887.pdf 1 16 text 0.99962544 "A inversão da sacarose ocorreu por hidrolise ácida , através adição de 0,4% de HCL 3M a uma solução de 500 g.L-1 de sacarose, com posterior aquecimento em banho-maria a 80°C por 30 minutos e posterior resfriamento até a temperatura ambiente. A neutralização do pH se deu por adição de uma solução de NaOH 3M, na mesma proporção do ácido." 1758 2105 W2249018887.pdf 1 17 separator 0.99716824 ¶ 2107 2109 W2249018887.pdf 1 18 title 0.99016035 3.3. Meio de cultura 2109 2130 W2249018887.pdf 1 19 separator 0.9958721 ¶ 2132 2134 W2249018887.pdf 1 20 text 0.996077 "Utilizou-se o meio sintético BGN para diluição e suplementação de nutrientes inorgânicos. A composição química do BGN é: K 2HPO 4 (0,03g.L-1), MgSO 4 (0,075g.L-1), CaCl 2.2H 2O (0,036g.L-1), citrato de amônio e ferro (0,0006g.L-1), Na 2EDTA (0,001g.L-1), NaCl (0,00072g.L-1), ácido cítrico (0,0006g.L-1), Na 2CO 3 (1,5g.L-1), metais traços: [H 3BO 3 (0,0028g.L-1), MnCl 2.4H 2O (0,0018g.L-1), ZnSO 4.7H 2O (0,00022g.L-1), Na 2MoO 4.2H 2O (0,00039g.L-1), CoSO 4.6H 2O (0,00004g.L-1). Empregou-se sacarose hidrolisada como fonte de carbono orgânico exógeno em diferentes concentrações afim de se obter as razões carbono/nitrogênio de 20, 30 e 40." 2135 2804 W2249018887.pdf 1 21 separator 0.9932065 ¶ 2805 2807 W2249018887.pdf 1 22 title 0.8250179 Área temática: Processos Biotecnol ógicos 2807 2849 W2249018887.pdf 1 23 separator 0.9659561 ¶ 2849 2851 W2249018887.pdf 1 24 paratext 0.88765633 2 2851 2853 W2249018887.pdf 1 0 title 0.8511901 Introduction 0 12 W4311325344.pdf 1 1 separator 0.99414814 ¶ 12 14 W4311325344.pdf 1 2 text 0.99971855 "Rapid scienti fic and technological advance is revolutionizing treatment options and research tools in the era of personalized cancer therapy. The advent of immune checkpoint inhibitors (ICI) targeting the immune system has found wide application across cancer histotypes and represents the principal therapeutic intervention for advanced cancer patients ( 1). However, intrinsic and on-treatment resistance development remains a challenge of this therapeutic approach and major effort is dedicated to elucidate the involved mechanisms ( 2). In depth analysis of tumor biopsies by multi omics approaches has provided insight into the complex scenario prevailing at tumor site, but these approaches have a major limitation as they give only a snapshot of the actual conditions and ignore tumor evolution during treatment ( 3,4). Co-clinical studies based on systems allowing the in-toto culture of tumor biopsies and the maintenance of the genomic and morphological characteristics of the original tumor may contribute filling this gap. In particular, ex vivo 3D culture platforms, which maintain most of the features of tumor immune microenvironment (TIME) ( 5)a n dc a p t u r ed r u g - mediated dynamic modulations, can elucidate molecular and immune-related mechanisms underlying clinical response or resistance to therapy ( 6). This approach could help gathering a comprehensive mechanistic overview and de fine predictive biomarkers of clinical outcome in patients treated with ICI ( 7)." 14 1551 W4311325344.pdf 1 3 separator 0.9551913 ¶ 1551 1553 W4311325344.pdf 1 4 text 0.99909645 "Here, we provide an overview of the relevance and potential implications of the tumor explant culture system in studying ICI responses. In addition, we show the advantages of a 3D platform of dynamic culture of tumor explants in a Bioreactor for profiling molecular and immunologic mechanisms induced by ICI in human metastatic melanoma (MM) and soft tissue sarcoma (STS) samples." 1553 1945 W4311325344.pdf 1 5 separator 0.9955865 ¶ 1945 1947 W4311325344.pdf 1 6 title 0.99211675 "Patient-derived models for cancer drug testing" 1947 1996 W4311325344.pdf 1 7 separator 0.9934014 ¶ 1996 1998 W4311325344.pdf 1 8 text 0.9996699 "The contribution of newly developed targeted drugs and immunotherapies to improve patient survival has been limited by the lack of appropriate experimental models maintaining original tumor microenviro nment (TME) architecture and composition. So far, patient-derived xenografts (PDX) have become the preferred tool for drug testing, to identify novel tumor markers and therapeutic targets and to translate findings aimed at optimizing treatment of cancer patients. PDX models generated from freshly resected tumor specimens or from tumor- derived organoids transplanted into immunode ficient mice preserve the tumor intrinsic heterogeneity and can recapitulate the interactions of cancer cells with the surrounding live environment, but not with the human immune system ( 8)." 1998 2797 W4311325344.pdf 1 9 separator 0.9067792 ¶ 2797 2799 W4311325344.pdf 1 10 text 0.9996791 "Humanized mice models grafted with human immune cellshave been generated to bypass this problem ( 9). Nonetheless, animal models are time consuming and have high costs, and thus may not represent the rational choice for real-time precision cancer therapy. Moreover, the advent of immune based- therapies requires models able to mimic native TIME. In this scenario 3D culture systems represent a valid alternative." 2799 3223 W4311325344.pdf 1 11 separator 0.98131144 ¶ 3223 3225 W4311325344.pdf 1 12 text 0.99975157 "3D models are classi fied into spheroids, organoids and patient-derived tumor explants (PDE), based on the structuralcomplexity. Spheroids are aggregates of cells obtained from cancer cell lines or tumor biopsies, self-assembling in an environment that prevents attachment to a flat surface. They are of low complexity in mirroring tumor organization, but they may retain their endogenous extracellular matrix and many metabolic similarities to the original tissue ( 10). Organoids are mini-organs reconstituted and embedded in an extracellular matrix reproducing many structural and functional aspects of the parental organ. In addition to the use of pluripotent stem cells, tissue-derived tumors from patients can also be established as organoids, namely patient-derived organoids (PDO) ( 11)." 3225 4041 W4311325344.pdf 1 13 separator 0.957515 ¶ 4041 4043 W4311325344.pdf 1 14 text 0.99973667 "PDO typically recapitulate features and genetic characteristics of the parental tumor, as observed in PDO from colorectal and gastroesophageal cancer patients ( 12). Of note, organoids and PDO can be expanded and cryopreserved, a fundamental feature especially for rare cancer types ( 13). However, these models are characterized by the inability of preserving the native features of TIME, and even the exogenous addition of selected immune cell populations as a co-culture is insuf ficient to reproduce the required complexity to evaluate the response to immunotherapy." 4043 4629 W4311325344.pdf 1 15 separator 0.96060884 ¶ 4629 4631 W4311325344.pdf 1 16 text 0.9997369 "A further level in TME complexity in 3D models is represented by PDE, that consist in the ex vivo culture of freshly-resected human tumor fragments. PDE recapitulate tissue architecture, TME and preserve the human immune system components, thus allowing the evaluation of drug responses in a 3D context. PDE preserve tumor-speci fic genetic alterations, transcriptomic pro files and histopathology of individual patients, allowing personalized drug screening and the identi fication of drug resistance mechanisms ( 14). LeBlanc and coworkers reported that glioblastoma-derived PDE largely retain genetic and transcriptomic heterogeneity of parent tumors, enabling the dissection of glioblastoma heterogeneity evolution during disease progression and treatment response (15). In a recent study, the inhibition of NOTCH signaling pathway in PDO of BRAFV600E/K601Q MM enhanced thesensitivity to the MEK inhibitor cobimetinib, thereby supporting the contribution of PDO models to identify therapy resistance mechanisms ( 16)." 4631 5682 W4311325344.pdf 1 17 separator 0.9448445 ¶ 5682 5684 W4311325344.pdf 1 18 text 0.999439 "PDE, endowed with the native TIME, represent ideal ex vivo models for immunotherapy studies. In fact, deciphering the dynamic interactions between tumor and immune cells provides insights into the mechanisms regulating sensitivity or resistance to immune-based therapies including ICI. A further PDE model consisting of patient-derived tumor tissuesembedded in collagen and termed organotypic tumor" 5684 6093 W4311325344.pdf 1 19 paratext 0.5502571 Rod 6093 6096 W4311325344.pdf 1 20 text 0.6653186 olfo et 6096 6103 W4311325344.pdf 1 21 paratext 0.8578475 al. 10.3389/ fimmu.2022.1068091 6103 6134 W4311325344.pdf 1 22 separator 0.8719301 ¶ 6134 6136 W4311325344.pdf 1 23 paratext 0.9756947 Frontiers in Immunology frontiersin.org 02 6136 6179 W4311325344.pdf 1 0 paratext 0.96526027 "408 P. T. Leivas et al. ZOOLOGIA 29 (5): 405–412, October, 2012" 0 65 W1986660288.pdf 3 1 title 0.60443825 The 65 68 W1986660288.pdf 3 2 text 0.9790346 "t-test, contingency tables, linear regression and Spearman’s correlation were performed using the program R (R D EVELOPMENT CORE TEAM 2009). Analyzes used to quantify the amplitude of the ecological niche of the species were carried out in the program PAST (H AMMER et al. 2001) and the overlap in food niche was performed using the EcoSim (G OTELLI & ENTSMINGER 2001). All statistical tests were performed with a sig- nificance level of 0.05 (C ALLEGARI -JACQUES 2006)." 68 559 W1986660288.pdf 3 3 separator 0.99398214 ¶ 559 561 W1986660288.pdf 3 4 title 0.98842263 RESULTS 561 569 W1986660288.pdf 3 5 separator 0.9955902 ¶ 569 571 W1986660288.pdf 3 6 text 0.99437237 "We analyzed a total of 181 samples L. catesbeianus , of which 104 were females and 77 were males. Of the total specimens collected, 173 were adults and eight were young females. TheSVL of females ranged between 60.0 and 162.0 mm and the BM ranged between 20.99 and 508.30 g. In males, the SVL varied between 76.0 and 156.0 mm and the varied BM between 38.48and 391.50 g. There was no sexual dimorphism in the SVL of adults (Welsh’s t-test = 0.41, df = 171, p = 0.52, mean ± 1 SD: Males – SVL = 119.1 ± 42.7 mm and Females – SVL = 117.0 ± 46.4mm) and the BM (Welsh’s t-test = 0.04, df = 171 and p = 0.83, mean ±1 SD: Males – BM = 195.23 ± 20.16 g females: BM = 22.49 ± 192.22 g) of the specimens collected." 571 1293 W1986660288.pdf 3 7 separator 0.98245084 ¶ 1293 1295 W1986660288.pdf 3 8 text 0.998665 "Spring was the season with a greatest abundance of indi- viduals (n = 59), followed by winter (n = 44), summer (n = 43) and fall (n = 35). The seasonal sex ratio of the total sampleshowed a significant difference only in the summer ( /H9273 2 = 3.93, df = 1, p < 0.05) when 15 males and 28 females were collected." 1295 1617 W1986660288.pdf 3 9 separator 0.9855403 ¶ 1617 1619 W1986660288.pdf 3 10 text 0.99923414 "Population’s diet. Among the stomachs examined, 12.71% (n = 23) were empty and 87.29% (n = 158) contained 1-78 items (mean 7.81 ± 1.56). The richness of prey items was not correlated with the biometric variables analyzed. However, the abundance of prey items was correlated with the SVL ( /H9267 = -0.145, p = 0.050) and the BM ( /H9267 = -0.165, p = 0.025), but not with the other variables. The size of the specimens analyzed (SVL) also was unrelated with the volume of prey in the population of L. catesbeianus (r 2 = 0.0005, F = 0.097, df = 180, p = 0.75)." 1619 2198 W1986660288.pdf 3 11 separator 0.9845692 ¶ 2198 2200 W1986660288.pdf 3 12 text 0.99947137 "Invertebrates were the most abundant items in the diet of the American Bullfrog (Tab. I), representing 86.20 % (n = 206)of the food items encountered by us. The following groups were identified: Arachnida, Mollusca, Myriapoda, Annelida, Crusta- cea and Insecta, the most abundant group, including ten or-ders found in the stomach contents (Tab. I). Vertebrates were represented by anurans in different ontogenetic stages and fish juveniles accounted for about 13.80 % (n = 33) of the preyitems (Tab. I). We considered as accidentally ingested items, plants (n = 85, encountered in 30% of the samples), rocks (n = 13, 4.5%) and feathers (n = 1, 0.4%)." 2200 2865 W1986660288.pdf 3 13 separator 0.9922079 ¶ 2865 2867 W1986660288.pdf 3 14 text 0.99694806 "Diet of juveniles and adults. The diet of young Ameri- can Bullfrogs consisted predominantly of invertebrates (PO = 88.9 %, n = 7), being represented by Insecta (PO = 66.7 %, n =6) and Arachnida (PO = 22.2 %, n = 2). The vertebrates found in the diet belong only to Osteichthyes (PO = 11.1 %, n = 1).The diet of adult bullfrogs consisted of items and their percentages as described in the general diet (Tab. I), with the exception of the items consumed by the juveniles. The diet ofadult males and females did not differ in the absolute frequency of occurrence of prey items ( /H9273 2 = 6.97; df = 7, p > 0.5), and all items were equally consumed by both sexes, except for Shell-fish, which were not preyed upon by females." 2867 3609 W1986660288.pdf 3 15 separator 0.9777022 ¶ 3609 3611 W1986660288.pdf 3 16 text 0.9948413 "The PO of vertebrates in the diet of females of L. catesbeianus was positively correlated with precipitation (/H9267 = 0.159, p = 0.620) and temperature ( /H9267 = 0.307, p = 0.330). The PO of vertebrates in the diet of males was positively corre- lated with the temperature ( /H9267 = 0.262, p = 0.410). However, the correlation with monthly precipitation was high and significant (/H9267 = 0.640, p = 0.024)." 3611 4036 W1986660288.pdf 3 17 separator 0.98774517 ¶ 4036 4038 W1986660288.pdf 3 18 text 0.9989721 "Seasonal diet. Invertebrates and vertebrates were preyed upon in all seasons. Among the invertebrates, only Mollusks were preyed upon only in the summer, and Annelids were preyed more intensively in the fall. The other groups had simi-lar rates of predation among seasons (Fig. 1)." 4038 4327 W1986660288.pdf 3 19 separator 0.98778874 ¶ 4327 4329 W1986660288.pdf 3 20 table 0.99441624 "3443 28 20 14119 9 2347 21170 60 50 40 30 20 10 0 AnnelidaArachnida CrustaceaInsectaMolluscaMyriapodaAnura Osteichthyes1222389 55 131" 4329 4497 W1986660288.pdf 3 21 separator 0.8620883 ¶ 4497 4499 W1986660288.pdf 3 22 title 0.74130666 Percentage of occurrence (PO%) 4499 4530 W1986660288.pdf 3 23 separator 0.9767189 ¶ 4530 4532 W1986660288.pdf 3 24 title 0.97955436 Taxonomic group 4532 4548 W1986660288.pdf 3 25 separator 0.9897891 ¶ 4548 4550 W1986660288.pdf 3 26 text 0.99941427 "Seasonally, vertebrates were consumed in greater numbers during the spring, followed by the winter, summer and fall months (Fig. 1). Fish were more intensely consumed in the spring but were not predated during the fall, and in winter and summerfish predation was low. The PO of fish in the diet did not differ significantly among the seasons ( /H9273 2 = 3.8, df = 3, p > 0.5) (Fig. 1)." 4550 4947 W1986660288.pdf 3 27 separator 0.89603525 ¶ 4947 4949 W1986660288.pdf 3 28 text 0.9994846 "Anurans in different ontogenetic stages were predated upon in all seasons, but were a more frequent diet item in the spring, followed by winter, summer and fall (Fig. 1). However, the PO was higher in winter than in spring and highest in thefall than in the summer (Fig. 1). The difference in predation was not significant between seasons ( /H9273 2 = 1.88, df = 3, p = 0.25)." 4949 5336 W1986660288.pdf 3 29 separator 0.89402246 ¶ 5336 5338 W1986660288.pdf 3 30 text 0.9990898 "Tadpoles were also present in the diet of L. catesbeianus in winter and summer seasons (PO = 50, n = 4 per station), but more frequently in the spring and fall (PO = 58, n = 7 and PO =" 5338 5527 W1986660288.pdf 3 31 caption 0.9945635 "Figure 1. Percentage of occurrence and number of items (above the bars) of each taxonomic group between the seasons, presentin the diet of adult Lithobates catesbeianus . Winter (black with white), spring (white), summer (black), and fall (grey)." 5527 5777 W1986660288.pdf 3 0 paratext 0.88527244 458 I. C. Nicu et al.: Multi-hazard susceptibility mapping of cryospheric hazards 0 81 W4285495610.pdf 11 1 separator 0.9938196 ¶ 81 83 W4285495610.pdf 11 2 caption 0.99496526 "Figure 8. Multi-hazard susceptibility map of TSs and TEGs for Nordenskiöld Land. The bar plot at the bottom right represents the number of grid cells expressed in logarithmic scale for each of the nine combined susceptibility classes." 83 324 W4285495610.pdf 11 3 separator 0.99614096 ¶ 324 326 W4285495610.pdf 11 4 title 0.9875924 "5 Considerations within and beyond Svalbard: supporting and opposing arguments" 326 407 W4285495610.pdf 11 5 separator 0.99272907 ¶ 407 409 W4285495610.pdf 11 6 text 0.99963766 "A systematic TS and TEG mapping protocol to share these cryospheric hazards among researchers has yet to root within the geoscientific community. This work aligns well with other attempts to make data on TSs and TEGs freely accessi- ble because we believe that the surface deformation dynam- ics of delicate environments laying within Arctic and peri- Arctic regions can be studied only as a collective effort. For this reason, we share our inventories in the hope of trigger- ing similar behaviours within our community and stimulating the implementation of advanced models, as per other mid- latitude hydro-morphological processes." 409 1062 W4285495610.pdf 11 7 separator 0.932107 ¶ 1062 1064 W4285495610.pdf 11 8 text 0.99969316 "Notably, until the use of automated mapping tools will be- come viable for cryospheric hazards, any manual mapping procedure such as the one we undertook here may suffer from subjectivity. To minimise any individual expert-based opinion and therefore remove its bias, in this work we im- plemented a collective mapping protocol in which two Arctic geomorphologists independently created the inventories only to be merged at a later stage. We believe this to be another re- quirement to be added to the collective effort we mention and recommend above. In fact, other studies have shown that col- lective mapping contributes to reducing uncertainties, which would otherwise become part of the data and propagate in any model one may build with it (Ardizzone et al., 2002)." 1064 1860 W4285495610.pdf 11 9 separator 0.97647274 ¶ 1860 1862 W4285495610.pdf 11 10 text 0.9996859 "Aside from the importance of a standard data-sharing plat- form within the global system, even just within the Sval- bard context, this is something of great relevance. In fact, the study site we chose had undergone significant changes in recent times. The work of Ziaja (2001) has shown the ex- tent of these changes in the form of permafrost degradation, whose dynamics can be better understood if framed within the bigger picture of the Svalbard meteorological settings.In fact, Nordenskiöld Land has always been covered with a lesser glacier extent compared to the rest of the archipelago." 1862 2471 W4285495610.pdf 11 11 separator 0.9534147 ¶ 2471 2473 W4285495610.pdf 11 12 text 0.99970454 "This is due to the direction the maritime air masses follow in the area. Specifically, the effect of the warm West Spits- bergen Sea Current creates a convergence of mild and hu- mid air from the south and chilly air from the north. This convergence results in a local micro-climate warmer than the rest of Svalbard and in general than what is typical at these latitudes. In addition to an already delicate situation, Ziaja (2001) observed that the deglaciation in Nordenskiöld Land has evolved at double the rate compared to Sørkapp Land (south Svalbard), arguing this to be an indication of a greater sensitivity of our study site to global warming." 2473 3144 W4285495610.pdf 11 13 separator 0.95663095 ¶ 3144 3146 W4285495610.pdf 11 14 text 0.9996528 "Therefore, we consider it vital to document and share ev- idence of permafrost degradation (our TS and TEG inven- tories) to reconstruct a baseline to which future monitoring protocols should refer for further exploring the effects of cli- mate change in the area. One of the possible tools to use to explore these effects falls in the category of data-driven mod- els, to which susceptibility studies belong. However, hardly any susceptibility studies have been carried out so far to esti- mate locations prone to TSs and TEGs in peri-Arctic regions (Blais-Stevens et al., 2015; Rudy et al., 2016; Veh, 2015)." 3146 3775 W4285495610.pdf 11 15 separator 0.98375726 ¶ 3775 3777 W4285495610.pdf 11 16 text 0.99887604 "Along this line of research, we proposed a tool for inter- pretable and flexible predictive models, offering the chance to explore the results from multiple aspects, among which we include a multi-hazard susceptibility assessment. The per- formance produced falls within the excellent class proposed by Hosmer and Lemeshow (2000). Therefore, standard prac- tices would consider that such a model results in a piece of reliable information for local administrators to base their decisions on and plan a suitable course of action to reduce the risk due to these cryospheric hazards. This is already an important achievement; however, below we would like to stress a few elements that we already envision requiring fur- ther considerations to develop our model into an operational tool. Both TS and TEG processes are shown to be highly dependent on soft sediment characteristics, data which are so far lacking on Svalbard. Adding map data with the type and potential thickness of surface sediments would further increase the accuracy and detail of predictions. The other prominent issue we faced had to do with the absent tem- poral information in our inventory. This is something that unfortunately affects virtually all the TS and TEG invento- ries mapped across the globe. For this reason, we are lim- ited to statically investigating and understanding locations prone to these hazards. However, this also raises the ques- tion of whether such information can be really used outside the academic context. In fact, any model without a tempo- ral connotation will inevitably learn to mimic the process that occurred at the time of the orthophoto or satellite im- age used for mapping. In other words, no temporal informa- tion on temperature, rainfall, or other dynamic characteris- tics can be included in the model. Therefore, in a rapidly changing environment such as the Svalbard landscape, the ¶" 3777 5737 W4285495610.pdf 11 17 paratext 0.9815226 Earth Syst. Sci. Data, 15, 447–464, 2023 https://doi.org/10.5194/essd-15-447-2023 5737 5819 W4285495610.pdf 11 0 paratext 0.9836681 ЕКОНОМІКА ТА СУСПІЛЬСТВО Випуск # 53 / 2023194 0 117 W4386486356.pdf 8 1 separator 0.9694766 ¶ 117 119 W4386486356.pdf 8 2 title 0.98894876 ОБЛІК І ОПОДАТКУВАННЯТаблиця 2 119 150 W4386486356.pdf 8 3 separator 0.91356313 ¶ 150 152 W4386486356.pdf 8 4 title 0.98713136 Оформлення листа стосовно виконання завдання узгоджених процедур 152 217 W4386486356.pdf 8 5 separator 0.9924041 ¶ 218 220 W4386486356.pdf 8 6 bibliography 0.63555783 МССП 4400 у старій редакції [9] МССП 4400 у новій редакції [8] 220 283 W4386486356.pdf 8 7 separator 0.9953244 ¶ 283 285 W4386486356.pdf 8 8 title 0.98219746 "Лист-зобов’язання завдання з узгоджених процедурЛист-угода стосовно завдання з узгоджених процедур" 285 392 W4386486356.pdf 8 9 separator 0.9878634 ¶ 392 394 W4386486356.pdf 8 10 text 0.99410963 "Кому [сторона, що наймає] Цей лист має підтвердити наше розуміння умов і цілей нашого завдання, а також характеру та обмежень обсягу послуг, які ми надамо. Наше завдання виконуватиметься згідно з Міжнародним стандартом супутніх послуг (або зазначити відповідні національні стандарти чи практики), який застосовується до завдань з узгоджених процедур, що буде зазначено в нашому звітіВи надіслали нам запит про реалізацію завдання з виконання узгоджених процедур по закупівлі [xyz] продуктів. Цей лист призначений для підтвердження нашого розуміння умов і цілей нашого завдання, а також характеру і обмежень послуг, які ми будемо надавати. Ми будемо здійснювати завдання відповідно до Міжнародного стандарту супутніх послуг (МССП) 4400 (переглянутий), Завдання з виконання узгоджених процедур. При виконанні узгоджених процедур ми будемо дотримуватися [описати відповідні етичні вимоги], що не вимагає від нас незалежності" 394 1384 W4386486356.pdf 8 11 separator 0.9356482 ¶ 1384 1386 W4386486356.pdf 8 12 text 0.99193275 "Ми погодилися виконати наведені далі процедури й надати вам звіт про фактичні результати, отримані у процесі нашої роботи: (Описати характер, строки і обсяг процедур, що виконуватимуться, включаючи (де це доречно) конкретне посилання на автентичність документів і записів, з якими треба ознайомитися, а також навести перелік контактних осіб і сторін, від яких будуть отримані підтвердження)Ви надіслали нам запит про реалізацію завдання з виконання узгоджених процедур по закупівлі [xyz] продуктів. Цей лист призначений для підтвердження нашого розуміння умов і цілей нашого завдання, а також характеру і обмежень послуг, які ми будемо надавати. Ми будемо здійснювати завдання відповідно до Міжнародного стандарту супутніх послуг (МССП) 4400 (переглянутий), Завдання з виконання узгоджених процедур. При виконанні узгоджених процедур ми будемо дотримуватися [описати відповідні етичні вимоги], що не вимагає від нас незалежності" 1386 2380 W4386486356.pdf 8 13 separator 0.6559637 ¶ 2380 2382 W4386486356.pdf 8 14 text 0.9932357 "Метою процедур, які ми виконуватимемо, є винятково надання Вам допомоги у (зазначити мету). Наш звіт призначений лише для Вас і не повинен використовуватися в жодних інших ціляхЗавдання з виконання узгоджених процедур, виконані відповідно до МССП 4400 (переглянутий) передбачає виконання узгоджених з вами процедур і повідомлення висновків у звіті про узгоджені процедури. Висновки – це фактичні результати виконаних узгоджених процедур. Ви [і, якщо це доречно, інші сторони] визнаєте, що процедури відповідають цілям завдання. Ми не робимо жодних заяв щодо доцільності процедур. Це завдання з виконання узгоджених процедур буде виконуватись на основі того, що [відповідальна сторона] несе відповідальність за предмет узгоджених процедур." 2382 3169 W4386486356.pdf 8 15 separator 0.56617844 ¶ 3170 3172 W4386486356.pdf 8 16 text 0.9988884 "Крім того, це завдання з виконання узгоджених процедур не є завданням по забезпеченню гарантій." 3172 3271 W4386486356.pdf 8 17 separator 0.63017255 ¶ 3272 3274 W4386486356.pdf 8 18 text 0.9962581 "Відповідно, ми не висловлюємо думки та не даємо висновки про надання впевненості Процедури, які ми виконаємо, не будуть аудитом чи оглядом, проведеним згідно з Міжнародними стандартами аудиту або Міжнародними стандартами завдань з огляду (або зазначити відповідні національні стандарти чи практики), а отже, ми не будемо висловлювати впевненості." 3274 3650 W4386486356.pdf 8 19 separator 0.5381218 ¶ 3651 3653 W4386486356.pdf 8 20 text 0.9971893 "Ми сподіваємось на повноцінну співпрацю з Вашими працівниками і на те, що нам будуть надані всі записи, документація та інша інформація, яка потрібна у зв’язку з нашим завданнямПроцедури, які ми будемо виконувати, призначені виключно для того, щоб допомогти вам визначити, чи відповідає ваша закупівля [xyz] продуктів вашій політиці закупівель. Відповідно, наш звіт буде адресований вам, і наш звіт може не підходити для інших цілей" 3653 4113 W4386486356.pdf 8 0 separator 0.9958433 ¶ 1 2 W4361013268.pdf 3 1 text 0.61621714 3.5.6 The water level of de 2 30 W4361013268.pdf 3 2 title 0.55166906 a 30 31 W4361013268.pdf 3 3 text 0.7455734 "erator and low- pressure heater may fluctuate when the cylinder cutting is on or off." 31 121 W4361013268.pdf 3 4 separator 0.9864434 ¶ 122 124 W4361013268.pdf 3 5 text 0.99117005 "When the deaerator water lev el alarm is high, open the deaerator overflow valve, close the stage by stage drainage of No. 3 high-press ure heater, and close the deaerator water feeding main control valve; Close the deaerator steam inlet valve and open the deaerator emergency drain valve." 124 429 W4361013268.pdf 3 6 separator 0.9768435 ¶ 430 432 W4361013268.pdf 3 7 text 0.9650778 "3.5.7 The thermal logic control problem causes a sudden change of a parameter or the cylinder cutting cannot be switched on or off normally." 432 579 W4361013268.pdf 3 8 separator 0.98582196 ¶ 580 582 W4361013268.pdf 3 9 text 0.9985685 "If the butterfly valve opening is not put into manual operation control when the low pressure cylinder zero output operation mode is exited, the butterfly valve opening is automatically tracked to calculate the butterfly valve opening of the automatic control circuit for heating and steam extraction pressure, which may lead to sudden change of the hydraulic butterfly valve opening when the low pressure cylinder zero output operation mode is exited, causing certain disturbance to the unit operation." 582 1101 W4361013268.pdf 3 10 separator 0.9664297 ¶ 1102 1104 W4361013268.pdf 3 11 text 0.9983693 "Considering that the unit is in operation, there are certain safety risks in online modification and downloading of control logic. It is recommended that the thermal engineering discipline forcibly exit the zero output exit button of the low pressure cylinder." 1104 1374 W4361013268.pdf 3 12 separator 0.9948969 ¶ 1375 1377 W4361013268.pdf 3 13 title 0.7568536 3.5.8 The cooling tower freezes 1377 1409 W4361013268.pdf 3 14 text 0.5763022 1409 1410 W4361013268.pdf 3 15 title 0.60417825 "during cylinder " 1410 1429 W4361013268.pdf 3 16 text 0.73945063 cutting operation. 1429 1447 W4361013268.pdf 3 17 separator 0.983499 ¶ 1448 1450 W4361013268.pdf 3 18 text 0.99883676 "Measures such as closing the water pouring in the cooling tower, switching the main bypass and covering the canvas are mainly taken. During actual operation, the operating personnel shall closely monitor and timely adjust the main steam pressure, water level of steam drum, w ater level of deaerator and condenser, etc., and monitor and record the vibration, differential expansion, axial displacement, secondary and final stage blade temperat ure, low pressure cylinder exhaust temperature and other parameters of the turbine shaft system. If the parameters change abnormally, suspend the operation in time and analyze the reasons. If the parameter exceeds the limit, the emergency response measures shall be followed." 1450 2201 W4361013268.pdf 3 19 separator 0.99625957 ¶ 2202 2204 W4361013268.pdf 3 20 title 0.97059435 4. Conclusion 2204 2218 W4361013268.pdf 3 21 separator 0.9959763 ¶ 2219 2221 W4361013268.pdf 3 22 text 0.9974165 "This paper mainly introduces the zero output heat supply transformation of low pressure cylinder in Shandong Province, the basic route and operation of the transformation, as well as thr ee different low pressure cylinder cooling steam systems, and introduces in detail the main risks and solutions in the cylinder cutting adjustment process for reference by power generation enterprises." 2221 2626 W4361013268.pdf 3 23 title 0.6831973 Acknowledgements 2626 2643 W4361013268.pdf 3 24 separator 0.97195745 ¶ 2644 2646 W4361013268.pdf 3 25 text 0.9865922 "This work was supported by the scientific and technological project of St ate Grid Shandong Electric Power Research Institute ""Research on Thermoelectric Cooperative Regulation Tech nology of Nuclear Power Units"" (ZY-2022-10)." 2646 2879 W4361013268.pdf 3 26 separator 0.9955406 ¶ 2880 2882 W4361013268.pdf 3 27 title 0.7471466 References 2882 2893 W4361013268.pdf 3 28 separator 0.9903228 ¶ 2894 2896 W4361013268.pdf 3 29 bibliography 0.9975518 "1. Ronghe Hao, Zhuang Li, Liping Wang, et al. Economic Analysis of Smooth Shaft Operation of Low Pressure Cylinder in 210 MW Unit[J]. Journal of Shenyang Institute of Engineering (Natural Science), 2020,16(02):25-28+44." 2896 3122 W4361013268.pdf 3 30 separator 0.90875155 ¶ 3123 3125 W4361013268.pdf 3 31 bibliography 0.99740565 "2. Jianxun Wang. Analysis of Flexible Peak-Load R egulation Capability and Economy on the Zero Output Technology of Low-Pressure Cylinder for 650 MW Supercritical Unit[J] .Journal of Engineering for Thermal Energy and Power,2021,36(02):18-23." 3125 3379 W4361013268.pdf 3 32 separator 0.9502729 ¶ 3380 3382 W4361013268.pdf 3 33 bibliography 0.9977629 "3. Tianfu Liang, Weiyang Xie, Fei Wang, et al.The key technique research of removing the low pressure cylinder of steam turbine[J].Turbine Technology, 2019, 61(6): 471–472." 3382 3561 W4361013268.pdf 3 34 separator 0.9655435 ¶ 3562 3564 W4361013268.pdf 3 35 bibliography 0.99744684 "4. Haisheng Yang, Tuo Zhang , GuangTong Tang, et al. Influence of Zero-Output Technology of Low-Pressure Cylinder on Deep Peak Regulation Performance of Heating Unit and Compensation Standard for Peak Regulation[J].Journal of Engineering for Thermal Energy and Power, 2020, 35(06):268-273.T" 3564 3867 W4361013268.pdf 3 36 separator 0.9748514 ¶ 3868 3870 W4361013268.pdf 3 37 bibliography 0.9973123 "5. Qinpeng Zhang, Xuedong Wang, Feng Li, et al. Analysis of Heating Capacity and Peak-regulating Capacity of 330 MW Steam Turbine Unit With Low- pressure Cylinder off Operation[J]. Shandong Electric Power, 2020,47(12):72-76." 3870 4106 W4361013268.pdf 3 38 separator 0.9673362 ¶ 4107 4109 W4361013268.pdf 3 39 bibliography 0.9976726 "6. Puxin Shi, Peiran Shi, Peiwen Wang, et al.Analysis and Operation Evaluation of Power Peak-shaving Ancillary Service Market in North China[J]. Automation of Electric Power Systems, 2021,45(20):175-184." 4109 4319 W4361013268.pdf 3 40 separator 0.9578206 ¶ 4320 4322 W4361013268.pdf 3 41 bibliography 0.9980109 "7. Xuhui Zhang, Zhonghua Zhao, Fuxing Cui, et al. Experimental Research on Deep Peak Regulation Characteristics of 1030 MW Ultra Supercritical Unit[J]. Shandong Electric Power, 2021,48(02):58-62." 4322 4521 W4361013268.pdf 3 42 separator 0.96046674 ¶ 4523 4525 W4361013268.pdf 3 43 bibliography 0.9973902 "8. Lingkai Zhu, Wei Zheng, Junshan Guo , et al. Application of Heat Load Distribution in Improving Peak-shaving Ability of Plant[J].Power System Engineering, 2019,35(06):43-46+49." 4525 4711 W4361013268.pdf 3 44 separator 0.9800917 ¶ ¶ 4712 4718 W4361013268.pdf 3 45 paratext 0.9647246 "4E3S Web of Conferences 375, 03025 (2023) https://doi.org/10.1051/e3sconf/202337503025 ESAT 2023" 4718 4818 W4361013268.pdf 3 0 paratext 0.9026369 6 0 1 W4225319080.pdf 5 1 separator 0.9862621 ¶ 1 3 W4225319080.pdf 5 2 text 0.9954892 "www.eurosurveillance.orgcampaign: 38.7%, 30.9% and 30.4%. Women repre - sented 78.4% of participants and 23.2%, 40.0% and 36.8%, respectively, were aged 18–34 years, 35–49 years and 50 years or older ( Table ). Nurses represented 22.9%, nurse assistants 9.4%, biomedical profession - als (including physicians, midwives, pharmacists and biologists) 27.7%, other paramedical staff 15.7% and administration staff 24.4% ( Table ). Among physicians in our sample, 59% were female and median age group was 35–49 years (cf.d with 50% and 49.3 years mean age according to official estimates in 2021 [ 16]). Among nurses, 85% were female and median age group was 35–49 years (cf.d with 88% and 40.2 years mean age in 2011 [ 17])." 3 762 W4225319080.pdf 5 3 separator 0.95149565 ¶ 762 764 W4225319080.pdf 5 4 text 0.9989197 "Working at least part-time in a nursing home was reported by 805 (15.4%) participants ( Table ). Three- thousand and thirty-four participants (58.1%) indicated vaccine intention against COVID-19, 1,153 (22.0%) indi - cated no intention, while 1,038 (19.8%) did not know yet. Among participants, 2,779 (53.1%) reported vacci - nation against influenza during the 2019/20 winter sea - son. The variable on receiving the previous influenza vaccine in 2019/20 was highly associated with COVID- 19 vaccine intention but not included in models to avoid overfitting (data not shown)." 764 1363 W4225319080.pdf 5 5 separator 0.99706835 ¶ 1363 1365 W4225319080.pdf 5 6 title 0.98758876 Exploration of model fit 1365 1390 W4225319080.pdf 5 7 separator 0.9931202 ¶ 1390 1392 W4225319080.pdf 5 8 text 0.99923366 "Compared with a model including the initial 5C item groups, the addition of confidence in systems and social conformism increased the model fit slightly but significantly, from R2 = 0.62 to 0.65 (p < 0.001) ( Figure 1). The model with attitude 7C-items only had a sub - stantially higher R2 when compared with the model with knowledge 7C-items only (0.64 vs 0.38)." 1392 1774 W4225319080.pdf 5 9 separator 0.8909099 ¶ 1774 1776 W4225319080.pdf 5 10 text 0.9979602 "Model fits (R2), corresponding to the percentage of variation in vaccine intention that can be explained, ranged from 0.17 to 0.51 for individual item groups (Figure 2 ). Confidence in systems and social conform - ism showed an R2 of 0.37 and 0.30, respectively." 1776 2050 W4225319080.pdf 5 11 separator 0.93135893 ¶ 2050 2052 W4225319080.pdf 5 12 text 0.99706924 "In a full model that included the shortlist KA-7C items and adjusted for socio-demographic characteristics (Supplementary Table S2 showing results of all KA-7C items), the strongest associations were observed for Figure 3" 2052 2285 W4225319080.pdf 5 13 separator 0.9951401 ¶ 2285 2287 W4225319080.pdf 5 14 title 0.9552036 Associations with COVID-19 vaccination intention among healthcare and welfare sector workers, France, 18 December 2287 2401 W4225319080.pdf 5 15 separator 0.3830821 2402 2403 W4225319080.pdf 5 16 table 0.917251 "¶ 2020–1 February 2021 (n = 5,234) at the start of the COVID-19 vaccination campaign 0.10 1.00 10.00 100.00Odds ratioNo fear of side e/uniFB00ect EU monitoring vaccines (K) Employer influence Skip control steps in vaccine development (K) Fear of severe form of COVID-19 Severity of epidemic (K) Two doses needed (K) Di/uniFB03cult access to vaccine More benefits than risks with vaccine More benefits than risks for people with risk factor (K) Collective action to stop epidemic Vaccine blocks transmission if infected (K) Family environment opinion" 2403 2989 W4225319080.pdf 5 17 separator 0.830432 ¶ 2989 2991 W4225319080.pdf 5 18 title 0.66286725 "Vaccine coverage among HCWs (K)" 2991 3025 W4225319080.pdf 5 19 separator 0.9825005 ¶ 3025 3027 W4225319080.pdf 5 20 text 0.839971 COVID-19: coronavisus disease; EU: European Union; HCWs: healthcare workers; K: knowledge variable. 3027 3127 W4225319080.pdf 5 21 separator 0.5311043 ¶ 3127 3129 W4225319080.pdf 5 22 text 0.64080924 a Points and bars represent odds ratios and 95% confidence intervals estimated in a multivariable model adjusting 3129 3244 W4225319080.pdf 5 23 table 0.43783793 age 3244 3247 W4225319080.pdf 5 24 text 0.66115135 "group, sex, professional category, work in a nursing home and study phase and including all KA-7C items of the questionnaire shortlist. b Only highest vs reference categories are shown." 3247 3438 W4225319080.pdf 5 25 separator 0.9937667 ¶ 3438 3440 W4225319080.pdf 5 0 text 0.9996208 "whether iron also impacts connectivity between the striatum and other RSNs. As such, we investigated whether striatal iron modulated the de- gree centrality and/or strength of the striatal components. The results showed that striatal iron was negatively associated with degree centrality of the putamen across the two groups (r 1⁄4- 0.42, p 1⁄40.007; FDR cor- rected: p 1⁄40.02; Fig. 3 ). Within age-group analyses revealed that this negative association was present in the older (r 1⁄4- 0.55, p 1⁄40.03) but not in the younger (r 1⁄4- 0.3, p 1⁄40.12) group. The correlation between iron in the striatum and strength of the putamen network did not reach conventional signi ficance (r 1⁄4/C00.22, p 1⁄40.18). No signi ficant associa- tion was found between striatal iron with either degree (r 1⁄40.04, p1⁄40.82) or strength (r 1⁄40.03, p 1⁄40.86) of the caudate RSN across the whole group." 0 884 W2886227394.pdf 5 1 separator 0.9777795 ¶ 884 886 W2886227394.pdf 5 2 text 0.999635 "Altogether, these findings suggest that higher striatal iron content was associated with a decrease in functional cross-talk between the pu- tamen and other RSNs across both age groups. Moreover, this association was more pronounced in the older group." 886 1144 W2886227394.pdf 5 3 separator 0.9972018 ¶ 1144 1146 W2886227394.pdf 5 4 title 0.9943267 3.5. Striatal resting-state networks, iron content, and motor performance 1146 1220 W2886227394.pdf 5 5 separator 0.99444956 ¶ 1220 1222 W2886227394.pdf 5 6 text 0.9933828 "Based on well-established links from previous literature, we hypoth- esized that the caudate and putamen networks would tax executive and motor processes ( Middleton and Strick, 2000 ;Gerardin et al., 2004 ; Monchi et al., 2006 ;Postuma and Dagher, 2006 ;Di Martino et al., 2008 ; Choi et al., 2012 ;Pauli et al., 2016 ;Haber, 2016 ). To investigate this, we tested for associations between the caudate and putamen and the Purdue Pegboard task. No signi ficant correlations were found between caudate resting-state measures and any of the tasks (p >0.05). We found a sig- nificant positive association between coherence of the putamen RSN and task performance with the dominant (right) hand (r 1⁄40.45, p 1⁄40.04) across both age groups ( Fig. 4 ). However, there were no associations with either the left hand or the assembly task (p >0.05). Correlations between striatal iron and the motor task at a whole-group level did not survive after controlling for age and sex. However, more exploratory analyses showed that, after performing a median split and looking only at in- dividuals with high iron content in the caudate and putamen compared to others in the same age group, there was a signi ficant association between striatal iron and motor performance with the dominant hand (r1⁄4/C00.539, p 1⁄40.047) across the sample." 1222 2574 W2886227394.pdf 5 7 separator 0.9972532 ¶ 2574 2576 W2886227394.pdf 5 8 title 0.99282056 3.6. Control analyses 2576 2598 W2886227394.pdf 5 9 separator 0.9962076 ¶ 2598 2600 W2886227394.pdf 5 10 text 0.9997799 "Although there was no relationship between striatal R2* rate and striatal volume in our sample (r 1⁄40.2, p 1⁄40.2), prior work on the relationship between striatal iron and cognitive and brain measures in- dicates that these may be confounded by striatal volume. As such, weperformed control analyses adjusting for striatal volume, which revealed very similar results to the ones reported in previous sections [Supple- mentary B]. A similar analysis was carried out with white-matter hyperintensities (WMH) as a covariate of no interest. This analysis also yielded very similar results to the ones reported above [details in Sup- plementary C]. Given that decreases in signal-to-noise ratio (SNR) are associated with increases in R2* values, we have taken SNR in the components of interest as a covariate [Supplementary D]. Importantly, we also tested for an association between SNR and R2* in the caudate (r1⁄4/C00.1, p 1⁄40.537) and putamen (r 1⁄40.0021, p 1⁄40.897) but these were not signi ficant. Finally, we were also interested to know whether the relationship between iron R2* and motor performance was mediated by functional connectivity. For this, we have performed a tentative mediation analysis with iron as the predictor variable, functional con- nectivity as the mediator, and motor performance as the outcome vari- able [Supplementary E]. We found that functional connectivity mediated the relation between iron and motor performance." 2600 4076 W2886227394.pdf 5 11 separator 0.9968691 ¶ 4076 4078 W2886227394.pdf 5 12 title 0.99054056 4. Discussion 4078 4092 W2886227394.pdf 5 13 separator 0.99688697 ¶ 4092 4094 W2886227394.pdf 5 14 text 0.99976355 "Our main aim was to investigate the relationship between striatal iron content and inter-individual differences in resting-state functional con- nectivity, and whether age affected this association. We have demon- strated for the first time that striatal iron was associated with functional connectivity in striatal resting-state networks. More speci fically, higher iron content correlated with lower coherence within the caudate andputamen networks. Our results also indicated that iron modulated con- nectivity of striatal networks to the rest of the brain. In general, these associations seemed to be more pronounced in the older group, however this should be interpreted with caution given that there were no group differences in degree of correlation between iron and functional con- nectivity. Finally, we showed that functional connectivity features affected by iron are behaviorally meaningful, so that the level of coher- ence within the putamen correlated with performance in a motor task." 4094 5117 W2886227394.pdf 5 15 separator 0.89143294 ¶ 5117 5119 W2886227394.pdf 5 16 text 0.99955964 "Overall, the present work makes a contribution to the literature on iron accumulation and its relation to functional brain integrity and cognition." 5119 5269 W2886227394.pdf 5 17 separator 0.9688516 ¶ 5269 5271 W2886227394.pdf 5 18 text 0.9997052 "Currently, little is known about the factors that modulate brain iron levels, including those that are modi fiable (e.g., life style; for a review see Kalpouzos , in press). Investigating these factors may help preventing or slowing down age-related iron accumulation and, consequently, preser- ving brain integrity." 5271 5595 W2886227394.pdf 5 19 separator 0.9753474 ¶ 5595 5597 W2886227394.pdf 5 20 text 0.9996998 "Higher levels of iron in the striatum were associated with lower resting-state coherence within the caudate and putamen networks. This association was more pronounced in the older group, especially for the caudate, suggesting that increased iron accumulation has a greater impact on striatal functional architecture in older age. As no study has" 5597 5951 W2886227394.pdf 5 21 separator 0.91608304 ¶ 5951 5953 W2886227394.pdf 5 22 caption 0.9713335 Fig. 1. Maps of the caudate and anterior cingulate cortex (in blue) and putamen (in red) networks.A. Salami et al. NeuroImage 183 (2018) 5953 6090 W2886227394.pdf 5 23 paratext 0.45345035 495 –503 6090 6099 W2886227394.pdf 5 24 separator 0.85632586 ¶ 6099 6101 W2886227394.pdf 5 25 paratext 0.9270783 499 6101 6105 W2886227394.pdf 5 0 paratext 0.8615419 "Case Reports in Radiology 3 (c) (a)" 0 37 W2923996451.pdf 2 1 separator 0.67309165 ¶ 37 39 W2923996451.pdf 2 2 title 0.4910995 ( 39 41 W2923996451.pdf 2 3 paratext 0.55284244 b) 41 43 W2923996451.pdf 2 4 separator 0.99624944 ¶ 43 45 W2923996451.pdf 2 5 caption 0.99660414 "Figure 3: Chest CT scan. (a) Consolidations with peripheral ground-glass opacities compatible with halo sign in the apical segments of the upper lobes (white arrow). (b) Nodule with central ground-glass density and consolidation ring (reversed halo sign) in the apical segment of the upper lobes (black arrow). (c) Coronal reconstruction. Multiple peripheral nodules, some of them with reversed halo sign (black arrow) and halo sign (white arrow)." 45 499 W2923996451.pdf 2 6 separator 0.48751295 499 500 W2923996451.pdf 2 7 caption 0.8536486 ¶ (a) 500 505 W2923996451.pdf 2 8 separator 0.48344874 505 506 W2923996451.pdf 2 9 caption 0.84644854 ¶ (b) 506 512 W2923996451.pdf 2 10 separator 0.9933315 ¶ 512 514 W2923996451.pdf 2 11 caption 0.99640864 "Figure 4: Chest X-ray. (a) There are no consolidations in the lung parenchyma or pleural effusion. US Testicular Doppler. (b) Testicle and left epididymis of normal size and vascularization." 514 707 W2923996451.pdf 2 12 separator 0.9266683 ¶ 707 709 W2923996451.pdf 2 13 text 0.9912698 "described include consolidation, lymph node enlargement, and pleural effusion [1]. CT scan is currently considered themethod of choice for evaluating patients suspected of SPE [5]." 709 892 W2923996451.pdf 2 14 separator 0.9604902 ¶ 892 894 W2923996451.pdf 2 15 text 0.9979675 "Findings on CT scans include bilateral nodules (82%), cavitation (55%), pleural effusion (29%), afferent vesselsign (27%), and parenchymal cuneiform opacities (17%). Inpatients with SPE, the halo sign has also been described [4]." 894 1128 W2923996451.pdf 2 16 separator 0.9742846 ¶ 1128 1130 W2923996451.pdf 2 17 text 0.99928737 "Epididymitis is the inflammation of the epididymis and can be associated with both infectious and noninfectious conditions. Epididymitis can be classified as acute or chronicaccording to the duration of symptoms (less than 6 weeksin acute forms). Bacterial infections constitute the mostcommon cause of acute epididymitis [2]." 1130 1461 W2923996451.pdf 2 18 separator 0.9472721 ¶ 1461 1463 W2923996451.pdf 2 19 text 0.99948275 "Overall, epididymitis in sexually active men under 35 years is unilateral and related to sexually transmittedmicroorganisms and, in older men, it is secondary touropathogens [3]. Clinical manifestations include gradual onset of testicular pain with unilateral radiation to the hypogastrium and scrotal edema. Other symptoms includeurethral secretion, dysuria, urgency, scrotal erythema, andfever [2]." 1463 1870 W2923996451.pdf 2 0 paratext 0.9788138 "11 Vol.:(0123456789) Scientific Reports | (2022) 12:9608 | https://doi.org/10.1038/s41598-022-12672-w www.nature.com/scientificreports/" 0 149 W4281742044.pdf 10 1 bibliography 0.9977484 "28. Glaser, A. K. et al. Three-dimensional cherenkov tomography of energy deposition from ionizing radiation beams. Opt. Lett. 38, 634–636. https:// doi. org/ 10. 1364/ OL. 38. 000634 (2013)." 149 348 W4281742044.pdf 10 2 separator 0.96846545 ¶ 348 350 W4281742044.pdf 10 3 bibliography 0.9979631 "29. Rilling, M., Allain, G., Thibault, S. & Archambault, L. Tomographic based 3D scintillation dosimetry using a three view plenoptic imaging system. Med. Phys. https:// doi. org/ 10. 1002/ mp. 14213 (2020)." 351 565 W4281742044.pdf 10 4 separator 0.9345857 ¶ 565 567 W4281742044.pdf 10 5 bibliography 0.99794275 "30. Rilling, M., Archambault, L. & Thibault, S. Simulating imaging-based tomographic systems using an optical design software for resolving 3d structures of translucent media. Appl. Opt. 58, 5942–5951. https:// doi. org/ 10. 1364/ AO. 58. 005942 (2019)." 568 827 W4281742044.pdf 10 6 separator 0.95292133 ¶ 827 829 W4281742044.pdf 10 7 bibliography 0.99465084 "31. Goulet, M. et al. Novel, full 3d scintillation dosimetry using a static plenoptic camera. Med. Phys.https:// doi. org/ 10. 1118/1. 48840 36 (2014)." 830 986 W4281742044.pdf 10 8 separator 0.9615959 ¶ 986 988 W4281742044.pdf 10 9 bibliography 0.99785614 32. Collett, E. Field guide to polarization (SPIE, Bellingham, Wash, 2005). 989 1066 W4281742044.pdf 10 10 separator 0.7418383 ¶ 1066 1068 W4281742044.pdf 10 11 bibliography 0.9976626 "33. Peshkov, A. Spin-polarization effects in cherenkov radiation from electrons. Can. J. Phys. 98, 660–663. https:// doi. org/ 10. 1139/ cjp- 2019- 0441 (2020)." 1069 1237 W4281742044.pdf 10 12 separator 0.9611381 ¶ 1237 1239 W4281742044.pdf 10 13 bibliography 0.9979206 "34. Doering, M., Bernloehr, K., Hermann, G., Hofmann, W . & Lampeitl, H. Measurement of the cherenkov light spectrum and of the polarization with the hegra-iact-system (2001)." 1240 1419 W4281742044.pdf 10 14 separator 0.90500337 ¶ 1419 1421 W4281742044.pdf 10 15 bibliography 0.9969795 35. Trimble Inc. Sketchup make. 1422 1454 W4281742044.pdf 10 16 separator 0.7311487 ¶ 1454 1456 W4281742044.pdf 10 17 bibliography 0.9979011 "36. Agostinelli, S. et al. Geant4a simulation toolkit. Nucl. Ins. Methods Phys. Res. Sec. A: Accel., Spectrom., Detect. Assoc. Equip. 506, 250–303. https:// doi. org/ 10. 1016/ S0168- 9002(03) 01368-8 (2003)." 1457 1675 W4281742044.pdf 10 18 separator 0.9550216 ¶ 1675 1677 W4281742044.pdf 10 19 bibliography 0.9979321 "37. Kawrakow, I., Mainegra-Hing, E., Rogers, D. W . O., Tessier, F. & Walters, B. R. B. The egsnrc code system: Monte carlo simulation of electron and photon transport. Technical Report PIRS-701, National Research Council Canada 323 (2021)." 1678 1922 W4281742044.pdf 10 20 separator 0.99086773 ¶ 1922 1924 W4281742044.pdf 10 21 title 0.9700429 Acknowledgements 1924 1941 W4281742044.pdf 10 22 separator 0.99103695 ¶ 1941 1943 W4281742044.pdf 10 23 text 0.99049306 "The authors thank Ghyslain Leclerc for the English revision of the paper. This work was financed by the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grants #2019-05038 and #2018- 04055. Emily Cloutier acknowledges support by the Fonds de Recherche du Quebec - Nature et Technologies (FRQNT)." 1943 2276 W4281742044.pdf 10 24 separator 0.99644095 ¶ 2276 2278 W4281742044.pdf 10 25 title 0.97257775 Author contributions 2278 2299 W4281742044.pdf 10 26 separator 0.9899167 ¶ 2299 2301 W4281742044.pdf 10 27 text 0.9943188 "E.C. designed and performed the experiments, analyzed the data and wrote the manuscript with critical input from L.B. and L.A. All authors reviewed the manuscript." 2301 2468 W4281742044.pdf 10 28 separator 0.9956888 ¶ 2468 2470 W4281742044.pdf 10 29 title 0.9709362 Competing interests 2470 2490 W4281742044.pdf 10 30 separator 0.9890154 ¶ 2492 2494 W4281742044.pdf 10 31 text 0.96229535 The authors declare no competing interests. 2494 2538 W4281742044.pdf 10 32 separator 0.9919367 ¶ 2538 2540 W4281742044.pdf 10 33 title 0.8944804 Additional information 2540 2563 W4281742044.pdf 10 34 separator 0.98273844 ¶ 2563 2565 W4281742044.pdf 10 35 contact 0.55941296 Correspondence 2565 2580 W4281742044.pdf 10 36 text 0.5432982 and 2580 2584 W4281742044.pdf 10 37 contact 0.4767049 requests 2584 2593 W4281742044.pdf 10 38 text 0.60842025 for materials 2593 2607 W4281742044.pdf 10 39 contact 0.5895538 should be addressed to É.C. or L.A. 2607 2643 W4281742044.pdf 10 40 separator 0.72836876 ¶ 2643 2645 W4281742044.pdf 10 41 contact 0.45045984 Re 2645 2648 W4281742044.pdf 10 42 text 0.45102063 prints and per 2648 2662 W4281742044.pdf 10 43 contact 0.4297645 missions information 2662 2682 W4281742044.pdf 10 44 text 0.44109547 is available 2682 2695 W4281742044.pdf 10 45 contact 0.48831832 at www. 2695 2703 W4281742044.pdf 10 46 text 0.51501864 nature 2703 2709 W4281742044.pdf 10 47 contact 0.5026498 . 2709 2710 W4281742044.pdf 10 48 text 0.44956145 com 2710 2713 W4281742044.pdf 10 49 contact 0.53142554 / 2713 2714 W4281742044.pdf 10 50 text 0.46798146 reprints. 2714 2723 W4281742044.pdf 10 51 separator 0.9907677 ¶ 2723 2725 W4281742044.pdf 10 52 title 0.82589555 Publisher’s note 2725 2742 W4281742044.pdf 10 53 text 0.65498626 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 2742 2864 W4281742044.pdf 10 54 separator 0.98486155 ¶ 2864 2866 W4281742044.pdf 10 55 paratext 0.93233913 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/." 2866 3749 W4281742044.pdf 10 56 separator 0.63890254 ¶ 3749 3751 W4281742044.pdf 10 57 paratext 0.9811556 © The Author(s) 2022 3751 3772 W4281742044.pdf 10 0 paratext 0.677589 "2 Case Reports in Pathology (a) (b)" 0 37 W2783627038.pdf 1 1 separator 0.9948238 ¶ 37 39 W2783627038.pdf 1 2 caption 0.9962604 "Figure 1: (a) Coronal view of noncontrast CT demonstrating left abdominal wall mass (arrow). (b) Axial view of noncontrast CT demonstrating left abdominal wall mass measuring approximately 7 cm ×5.5 cm (arrow)." 39 252 W2783627038.pdf 1 3 separator 0.9321513 ¶ 252 254 W2783627038.pdf 1 4 text 0.9968164 "have a known history of employment in manufacturing or significant chemical handling. There was no known familyhistory of genetic conditions that would predispose thepatient to multiple malignancies." 254 456 W2783627038.pdf 1 5 separator 0.9316689 ¶ 456 458 W2783627038.pdf 1 6 text 0.9984823 "The patient progressively worsened over months; he developed nausea, dry heaving, and decreased appetite. CT oft h ec h e s ta n dH I D As c a nh a db e e np e r f o r m e dw h i c hr e v e a l e dnonobstructive cholelithiasis with normal gallbladder func-tion. The patient subsequently underwent a noncontrast CTof abdomen and pelvis, which revealed a large abdominalmass measuring 7 cm ×5.5 cm abutting the mid portion of t h et r a n s v e r s ec o l o n ,w i t hn u m e r o u sm e t a s t a t i cf o c ii nt h eliver, lymphadenopathy adjacent to the pancreatic head, alarge lytic lesion involving the tenth rib, and scattered lyticareas throughout the spine and left iliac wing (Figure 1). Thepatient then underwent core biopsy of the abdominal mass." 458 1217 W2783627038.pdf 1 7 separator 0.98012125 ¶ 1217 1219 W2783627038.pdf 1 8 text 0.99844587 "I n i t i a lc o r eb i o p s yo ft h ea b d o m i n a lm a s sr e v e a l e dh i g h l y vascular tissue, the majority necrotic, with small atypical cellsseen on frozen section. Immunohistochemical staining forRCC was negative. CD10 was equivocal with chromograninA and podoplanin (D240) both being negative. Vimentin wasstrongly positive. A consult was made, an additional stainingincluding Cam 5.2, CD31, and ERG. Cam 5.2 revealed raremesothelial cells and the vascular proliferation was positivefor both CD31 and ERG. It was concluded that the degree ofnecrosis precluded a definitive diagnosis but that a vascular neoplasm or well-differentiated angiosarcoma could not be excluded." 1219 1912 W2783627038.pdf 1 9 separator 0.93668824 ¶ 1912 1914 W2783627038.pdf 1 10 text 0.99924535 "Repeat core liver biopsy and immunohistochemical stain- ing were performed at an outside institution. The liver biopsy delineated a very hypercellular specimen (Figure 2(a))." 1914 2093 W2783627038.pdf 1 11 separator 0.92541873 ¶ 2093 2095 W2783627038.pdf 1 12 text 0.99966794 "The tumor was comprised of a prominent vasoformative network (Figure 2(b)). The endothelial lining cells wereplump and pleomorphic. They had high nuclear to cyto-plasmic ratio with hobnailing hyperchromatic nuclei. The cytoplasm was eosinophilic with indistinct cell borders. The cytology delineated a hypercellular aspirate (Figure 3). Thecells formed a tightly cohesive cluster of epithelioid cells.The cells harbored hyperchromatic nuclei with eosinophiliccytoplasm. On occasion, the cytoplasm demonstrated cyto-plasmic vacuoles and intracytoplasmic lumina. Focally, theclusters were composed of very atypical spindle cells. Thecytology specimen stained negative for cytokeratin AE1/AE3a n dp o s i t i v i t yf o rC D 3 1a n dC D 3 4 .S i n c et h es p e c i m e nstained for two vascular immunohistochemical stains (CD31and CD34) in conjunction with pancytokeratin negativity, adiagnosis of angiosarcoma was rendered (Figures 2(c) and2(d))." 2095 3047 W2783627038.pdf 1 13 separator 0.96121264 ¶ 3047 3049 W2783627038.pdf 1 14 text 0.99935365 "The patient was scheduled for systemic chemotherapy with doxorubicin as well as palliative, single modality radi-ation therapy of the spine. Radiation was completed first. Thepatient’s chemotherapy regimen was changed to taxol rathert h a nd o x o r u b i c i nd u et ol o we j e c t i o nf r a c t i o ns e e no nM U G Ascan. However, prior to initiation of chemotherapy the patientwas hospitalized for confusion, lethargy, and enterococcalbacteremia. The decision was made to discharge the patientwith hospice care and he died 13 days later." 3049 3595 W2783627038.pdf 1 15 separator 0.99652976 ¶ 3595 3597 W2783627038.pdf 1 16 title 0.9875326 3. Discussion 3597 3611 W2783627038.pdf 1 17 separator 0.9960625 ¶ 3611 3613 W2783627038.pdf 1 18 text 0.9996611 Angiosarcoma is a rare subtype of sarcoma characterizedby endothelial cell proliferation, most frequently occurringin the elderly [2]. It may arise anywhere in the body, butcutaneous head and neck lesions are seen most commonly. 3613 3842 W2783627038.pdf 1 19 separator 0.5897988 ¶ 3842 3844 W2783627038.pdf 1 20 text 0.99949384 "Immunohistochemical staining generally includes positivity for CD31, CD34, factor VIII, agglutinin 1, and VEGF [9]. AnERG, a newer vascular stain, usually demonstrates nuclearpositivity. Presentation is nonspecific, though it has beensuggested that malignant ascites is the most frequently seenmanifestation [6]. The hepatic variant of angiosarcoma is bestknown for its relationship to chemical exposures but remainsa rare entity that can be mistaken for atypical hepatocellularcarcinoma [2]. To our knowledge, the patient described didnot experience significant ascites but did develop anasarcalater in his disease." 3844 4463 W2783627038.pdf 1 21 separator 0.9618535 ¶ 4463 4465 W2783627038.pdf 1 22 text 0.99888057 "The differential diagnosis in this patient is renal cell carcinoma (RCC), unclassified for which he underwent a" 4465 4579 W2783627038.pdf 1 0 title 0.49995297 ARTI 0 4 W3022402141.pdf 0 1 paratext 0.5103239 CLE 4 7 W3022402141.pdf 0 2 separator 0.9841016 ¶ 7 9 W3022402141.pdf 0 3 title 0.98135364 "A self-operating broadband spectrometer on a droplet" 9 64 W3022402141.pdf 0 4 separator 0.995005 ¶ 64 66 W3022402141.pdf 0 5 bibliography 0.98187923 P. Malara1✉, A. Giorgini1, S. Avino1, V. Di Sarno1, R. Aiello1, P. Maddaloni1, P. De Natale2& G. Gagliardi1 66 174 W3022402141.pdf 0 6 separator 0.9934602 ¶ 174 176 W3022402141.pdf 0 7 text 0.99516505 "Small-scale Fourier transform spectrometers are rapidly revolutionizing infrared spectro- chemical analysis, enabling on-site and remote sensing applications that were hardly ima-ginable just few years ago. While most devices reported to date rely on advanced photonicintegration technologies, here we demonstrate a miniaturization strategy which harnessesunforced mechanisms, such as the evaporation of a liquid droplet on a partially re flective substrate. Based on this principle, we describe a self-operating opto fluidic spectrometer and the analysis method to retrieve consistent spectral information in spite of the intrinsicallynon-reproducible droplet formation and evaporation dynamics. We experimentally realize thedevice on the tip of an optical fiber and demonstrate quantitative measurements of gas absorption with a 2.6 nm resolution, in a 100 s acquisition time, over the 250 nm spanallowed by our setup ’s components. A direct comparison with a commercial optical analyzer clearly points out that a simple evaporating droplet can be an ef ficient small-scale, inex- pensive spectrometer, competitive with the most advanced integrated photonic devices.https://doi" 176 1364 W3022402141.pdf 0 8 paratext 0.76676834 . 1364 1365 W3022402141.pdf 0 9 text 0.76117724 org/10.1038/s41467 1365 1383 W3022402141.pdf 0 10 paratext 0.7221313 -020-16206-8 OPEN 1383 1400 W3022402141.pdf 0 11 separator 0.99105173 ¶ 1400 1402 W3022402141.pdf 0 12 contact 0.9889474 "1Consiglio Nazionale delle Ricerche, Istituto Nazionale di Ottica (INO), via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy.2Consiglio Nazionale delle Ricerche, Istituto Nazionale di Ottica (INO), Largo E. Fermi 6, 50125 Firenze, Italy.✉email: pietro.malara@ino.cnr.it" 1402 1674 W3022402141.pdf 0 13 separator 0.97470105 ¶ 1674 1676 W3022402141.pdf 0 14 paratext 0.98139614 NATURE COMMUNICATIONS | (2020) 11:2263 | https://doi.org/10.1038/s41467-020-16206-8 | www.nature.com/naturecommunications 11234567890():,; 1676 1823 W3022402141.pdf 0 0 paratext 0.9027251 MediatorsofInflammation 5 0 25 W2572298800.pdf 4 1 separator 0.6400763 ¶ 25 27 W2572298800.pdf 4 2 paratext 0.9774034 Counts39 64 27 39 W2572298800.pdf 4 3 separator 0.9820303 ¶ 39 41 W2572298800.pdf 4 4 table 0.8922834 "T-betWT Gnaq−/− (a) ∗∗T-bet+(%) 020406080 WTGnaq−/− (b)" 41 107 W2572298800.pdf 4 5 separator 0.990219 ¶ 107 109 W2572298800.pdf 4 6 caption 0.9039912 Figure3:LossofGαqenhancestheexpressionofT-bet.(a)Purifiedna ̈ıveCD4+TcellsfromWTand Gnaq−/−micewerestimulatedwith ¶ 109 225 W2572298800.pdf 4 7 text 0.5010016 anti- 225 231 W2572298800.pdf 4 8 caption 0.54370284 CD 231 233 W2572298800.pdf 4 9 text 0.5442963 3/ 233 235 W2572298800.pdf 4 10 caption 0.8637166 "CD28(3μg/mL),inthepresenceofmouseIL-12(20ng/mL),mouseIL-2(20ng/mL),andanti-IL-4(10 μg/mL)forfivedays.Cells were harvested, fixed, permeabilized, and stained with PE-cy7-conjugated anti-T-bet and analyzed by flow cytometry. (b) The percentage" 235 478 W2572298800.pdf 4 11 text 0.5935754 478 479 W2572298800.pdf 4 12 caption 0.47346362 ¶ 479 480 W2572298800.pdf 4 13 text 0.5772693 of T-bet+cells 480 495 W2572298800.pdf 4 14 caption 0.5863803 was calculated. 495 511 W2572298800.pdf 4 15 text 0.694074 All data are presented as mean 511 542 W2572298800.pdf 4 16 caption 0.5032248 542 543 W2572298800.pdf 4 17 text 0.7918675 "±SD;∗∗P<0.05,n=3. The result is representative of three independent experiments." 543 625 W2572298800.pdf 4 18 separator 0.7221706 ¶ 625 627 W2572298800.pdf 4 19 text 0.99659 "collected and cytokine concentrations were measured by ELISAassay.ResultdemonstratedthatsecretionlevelofIFN-γwasalsomuchhigherin Gnaq−/−CD4 +Tcell(Figure2(c))." 627 791 W2572298800.pdf 4 20 separator 0.65313905 ¶ 791 793 W2572298800.pdf 4 21 text 0.998427 TheseresultsshowedthatGαqregulatesTh1differentiation. 793 847 W2572298800.pdf 4 22 separator 0.99642164 ¶ 847 849 W2572298800.pdf 4 23 title 0.9869269 3.3. Absence of Gαq Heightened the Expression of T-Bet 849 904 W2572298800.pdf 4 24 separator 0.58896995 ¶ 904 906 W2572298800.pdf 4 25 title 0.71559554 and p 906 912 W2572298800.pdf 4 26 text 0.6505343 -STAT4 in CD4+ 912 926 W2572298800.pdf 4 27 title 0.5847657 TC e l 926 932 W2572298800.pdf 4 28 text 0.99385464 "l s .Results presented above identified a negative role of G αq in Th1 differentiation. T- bet, a Th1-specific T box transcription factor that controlsthe expression of IFN-γ, is a critical regulator for Th1 cell differentiation[19].Toexploreunderlyingmechanismoftheregulation of Gαq in Th1 differentiation, we next detected the status of T-bet in WT and Gnaq−/−CD4 +T cells under Th1 polarizing condition. After 5 days of induction, cellswere harvested and expression of T-bet was analyzed byflow cytometry (Figure 3(a)). Result showed that expression level of T-bet was dramatically increased in Gnaq−/−CD4 + Tc e l l sc o m p a r e dw i t hW TC D 4+T cells (Figure 3(b)). As STAT4 is also a critical factor in Th1 differentiation, wefurther measured the phosphorylation of STAT4 by flowcytometry.Thelevelofphospho-STAT4wasobviouslyhigherinGnaq−/−CD4 +T cells than WT controls (Figure 4)." 932 1845 W2572298800.pdf 4 29 separator 0.8542987 ¶ 1845 1847 W2572298800.pdf 4 30 text 0.9981142 "Therefore, results demonstrate that G αq regulates Th1 cell differentiation by modulating T-bet and STAT4 in Gnaq−/− mice." 1847 1974 W2572298800.pdf 4 31 separator 0.9958515 ¶ 1974 1976 W2572298800.pdf 4 32 title 0.98553866 3.4. Percentage of Th1 Cells Was Increased in Gnaq −/−BM 1976 2033 W2572298800.pdf 4 33 separator 0.96784425 ¶ 2033 2035 W2572298800.pdf 4 34 text 0.9937153 "ChimerasSpontaneouslyDevelopingArthritis. Wehaveiden- tified a negative correlation between G αqa n dh a l l m a r kTh 1 cytokine (IFN-γ)i nR Ap a t i e n t sa n dan e g a t i v er o l eo fG αq" 2035 2233 W2572298800.pdf 4 0 text 0.9956487 "seerd worden. Uit dien hoofde kunnen gevalstu- dies behulpzaam zijn in het organisatieonder­ zoek. Beschrijvende gevalstudies concentreren zich in hoofdzaak op het zo nauwgezet mogelijk verhalen van de werkelijke gang van zaken in dat deel van de werkelijkheid, waar de aandacht in het bijzonder naar uitgaat. Het is de probleem­ stelling die aangeeft wat zo nauwkeurig mogelijk beschreven dient te worden. Het gaat in deze gevalstudies om het stellen van ’wie, wat en welk’-vragen (Verschuren, 1986).1" 0 530 W2971366737.pdf 5 1 paratext 0.38088587 0 530 532 W2971366737.pdf 5 2 text 0.99970526 "Het is echter moeilijk aan de hand van verkennende en beschrijvende gevalstudies tot theorie-ontwikke- ling te komen. Dit heeft te maken met het feit dat het respectievelijk verkennen en beschrijven reeds een doel op zich is. Voor bijvoorbeeld een verklarende gevalstudie geldt dat het verkennen en beschrijven louter een middel is om tot het onderkennen van oorzakelijkheidsrelaties te komen. Verklarende gevalstudies hebben in het organisatie-onderzoek dan ook als doel de oorza­ kelijkheidsrelaties die bestaan tussen organisatie- verschijnselen bloot te leggen. Verklarende gevalstudies bieden daardoor mogelijkheden tot voorspelling (Verschuren, 1986)."" Aan de hand van verklarende gevalstudies kunnen we aanto­ nen dat bepaalde organisatiefenomenen (bijvoor­ beeld strategieveranderingen) leiden tot andere organisatiefenomenen (bijvoorbeeld structuurver­ anderingen). Tevens is het mogelijk de richting van de oorzakelijkheid vast te stellen. De moge­ lijkheden voor theorievorming zijn deswege gro­ ter. Bij gevalstudies die aanleiding kunnen geven tot het ontwikkelen van theorieën geldt dat impliciet wordt uitgegaan van de veronderstelling, dat de resultaten van de gevalstudie(s) over meerdere gevallen gegeneraliseerd kunnen worden (een extern geldigheidsvraagstuk). Deze veronderstel­ ling zal expliciet gemaakt moeten worden. Som­ mige gevalstudies worden immers louter als voorbeeld opgevoerd, en hebben in het geheel niet de pretentie externe geldigheidswaarde te bezitten. Daarmee zijn we aanbeland bij de laatste functie van een gevalstudie: de gevalstudie als illustratie van een theoretisch construct dat de betreffende onderzoeker(s) nader wil(len) bena­ drukken. Zo was de functie van het beknopt behandelen van de internationale joint ventureNUMMI (tussen General Motors en Toyota) in het artikel van Jagersma en Bell (1992) louter illustra­ tief. Het doel was om aan te geven dat een inter­ nationale joint venture een medium kan zijn voor het genereren van een produkt (een automobiel) en/of een dienst (een leerproces). Daarmee werd een theoretisch construct inzichtelijk gemaakt." 533 2759 W2971366737.pdf 5 3 separator 0.8526639 ¶ 2759 2761 W2971366737.pdf 5 4 text 0.9990292 "Gevalstudies kunnen in bepaalde omstandighe­ den krachtige illustraties zijn voor op het eerste gezicht complexe theoretische constructen en relaties." 2761 2920 W2971366737.pdf 5 5 separator 0.9965894 ¶ 2920 2922 W2971366737.pdf 5 6 title 0.98867005 4.3 Minpunten 2922 2936 W2971366737.pdf 5 7 separator 0.9960078 ¶ 2936 2938 W2971366737.pdf 5 8 text 0.99969745 "Dat neemt niet weg dat het toepassen van geval­ studies met nogal wat haken en ogen is omge­ ven. Gevalstudies zouden vanuit methodologisch perspectief weinig robuust zijn. Naar aanleiding van gevalstudies gegenereerde kennis zou daar­ door niet betrouwbaar zijn en daarmee weinig wetenschappelijk. Gevalstudies zijn daarenboven vaak tijdrovende exercities. Dit maakt het toepas­ sen van gevalstudies niet zelden tot een kostbare aangelegenheid. Door het tijdrovende karakter van gevalstudies kan pas na lange tijd bepaald worden in hoeverre de gevalstudie geslaagd is c.q. beantwoord heeft aan de oorspronkelijke doelstelling(en) (i.e. zoals weergegeven in de probleemstelling). Nauw hiermee verweven is het derde kritiekpunt. Gevalstudies willen nog wel- eens resulteren in enorme hoeveelheden gege­ vens. Dit maakt gevalstudies tot moeilijk 'beheersbare' onderzoeksstrategieën. Een vierde kritiekpunt concentreert zich op de geringe gene­ ralisatiemogelijkheden van organisatie-onderzoek dat gebruik maakt van gevalstudies. Het gaat hier om het 'bereik' van de naar aanleiding van de gevalstudie gegenereerde inzichten (i.e. een extern geldigheidsvraagstuk). Tot slot wordt de gevalstudie wel opgevat als een voorbode voor het 'echte' onderzoek. De gevalstudie als vere­ delde 'pilot study’. Volgens deze opvatting zijn onderzoekers aan de hand van het praktiseren van gevalstudies slechts in staat theoretische constructen beter de definiëren, onderzoeksvra­ gen te actualiseren (alsmede nieuwe onder­ zoeksvragen te ontwikkelen) en het onderzoeks-" 2938 4579 W2971366737.pdf 5 9 separator 0.84290177 ¶ 4579 4581 W2971366737.pdf 5 10 paratext 0.98784435 62 januari/febm ari 1993 4581 4606 W2971366737.pdf 5 11 separator 0.9936524 ¶ 4606 4608 W2971366737.pdf 5 0 paratext 0.88789076 KALMAN FILTER RESIDUAL EXPERT SYSTEM 0 36 W2160234371.pdf 0 1 separator 0.6718817 ¶ 37 39 W2160234371.pdf 0 2 contact 0.7270444 "Captain Jeff Grimshaw and Major Phil Amburn AFIT/EN G Wright-Patterson AFB, Ohio" 39 126 W2160234371.pdf 0 3 separator 0.99040544 ¶ 127 129 W2160234371.pdf 0 4 title 0.93565786 Abstract 129 138 W2160234371.pdf 0 5 separator 0.9956324 ¶ 139 141 W2160234371.pdf 0 6 text 0.9953476 "The Pilot's Associate (PA) program has been initiated to liclp mitigate the extensive workload of the fightcr pilot. To operate effectively, tlie PA system must have situation awareness: an integrated ""feel"" for the condition of on-board systems and the status and significance of external objects. Thus, the PA must continually monitor and evaluate im- portant aircraft, weapon, and threat systems as well as terrain and weather conditions. Thc required information is gained llirougli sensor systcms. The data from these systems must be ""fused"" together to present tlie PA with a coherent picture of the environment. One common technique for fusing sensor data uses Kalman filters in a multiple model adaptive filter (WAF)." 141 903 W2160234371.pdf 0 7 separator 0.89887166 ¶ 904 906 W2160234371.pdf 0 8 text 0.99965894 "Wc prcscnt an iniprovcd filtcr sclcction tcchniquc as part of an advanced MMAF. A knowlcdgc-bascd system is used to augment the usual sclcction technique, and preliminary rcsults indicate that tliis approach hclps in situations that arc known to cause problems for Kalman filtcr-based MMAF systems." 906 1217 W2160234371.pdf 0 9 separator 0.9971808 ¶ 1218 1220 W2160234371.pdf 0 10 title 0.98436004 Historical Background. 1220 1243 W2160234371.pdf 0 11 separator 0.99512374 ¶ 1244 1246 W2160234371.pdf 0 12 text 0.9997291 "The workload of the fightcr pilot has becn stcadily in- creasing. Today's pilot is expcctcd to kecp track of a myriad of systcms arid sub-systcnis, clicckirig than for anomalics, wliilc simultaneously engaging a targct and possibly cvading a hostile threat. This workload will continuc to iiicrcasc as tlic ncxt gcncratiori of figlitcr aircraft introduce ncw scnsors to which llie pilot must rcspond." 1246 1665 W2160234371.pdf 0 13 separator 0.79706466 ¶ 1666 1668 W2160234371.pdf 0 14 text 0.9993001 "I'hc inforniation contcnt of tlic scnsor ""subsystcnis"" is stcadily increasing through innovations such as active-clcnicnt phased-array radar antcnnas, focal-plane array infrarcd sensors, on-board digital tcrrain and lcaturc storage systcms. high-scnsitivity with high-angular accuracy anti-radiation sensors, iniprovcd navigation sensors and intcgratcd coniniunications systcnis" 1668 2065 W2160234371.pdf 0 15 separator 0.963502 ¶ 2066 2068 W2160234371.pdf 0 16 paratext 0.9875113 [ 4,p. 1 3 3 01. 2068 2085 W2160234371.pdf 0 17 separator 0.9944972 ¶ 2086 2088 W2160234371.pdf 0 18 text 0.99951935 "To alleviate tlic workload of futurc fightcr pilots, tlic Defense Advanced Research Projects Agency (DARPA) has created the Pilot's Associate (PA) Program. The specific pur- pose of this program is to demonstate and evaluate die use of artificial intelligence (AI) and expert systems for increasing the effectiveness of future combat aircraft. The kernel task of die PA system is the retrieval of available sensor data and the development of assessments based upon that data. Without this ""real world"" information, the system can neither suggest nor initiate logical actions." 2088 2688 W2160234371.pdf 0 19 separator 0.9965042 ¶ 2689 2691 W2160234371.pdf 0 20 title 0.9831745 Sensor Fusion. 2691 2706 W2160234371.pdf 0 21 separator 0.995434 ¶ 2707 2709 W2160234371.pdf 0 22 text 0.99966097 "A significant problem with perceiving the external state is Uie uncertainty associated with the sensed data. Sensors may be designed to provide various types of information about potential threats. Each sensor has its own strengths and weakncsses arid thus supplies data with varying degrees of precision and accuracy. For instance, a laser rangefinder may provide excellc~it range data and relatively poor elevation and azimiitli data. By combining data from various sources, using some type of sensor fusion process, complementary and compcting interpretations can be combined to determine the most likely cxtenial state." 2709 3363 W2160234371.pdf 0 23 separator 0.91589546 ¶ 3364 3366 W2160234371.pdf 0 24 text 0.99246395 "Tlirce categorics of techniques have been developed to ntldrcss the fusion problem. Thc first uses AI techniques dcveloped to facilitate reasoning under uncertainty (RUU). This twlinique uses processed data, possibly refined by Kalman filters. The second tcchnique is a hybrid approach that attempls to address bolli the post-filter RUU techniques as well as tlie proccssing of the raw data that occurs within the filters. Thc last tcclinique conccntrates on the processes that go on within tlie Khan filter system, using expert knowlcdge to make improvements in performance." 3366 3969 W2160234371.pdf 0 25 separator 0.88390684 ¶ 3970 3972 W2160234371.pdf 0 26 text 0.998996 "A fairly comprchcnsive rcvicw of current work in hantlling uncertainty in expcrt systems has bccn written by P.P. Boriissorie 121. Hc concludes that there are two basic ap- proaclics to rcprcscriting unccrtainty: numcrical and symbolic charactcri~itions [2,p.2]. Numerical approaches are cliaractcr- izcd by valucs rcprcscntcd by a single numbcr or an interval." 3972 4349 W2160234371.pdf 0 27 separator 0.6775391 ¶ 4350 4352 W2160234371.pdf 0 28 text 0.99765074 "An examplc of this approach is the Evidcntial Reasoning work done by Thomas Garvey, et. al., [5,p.319]. This technique is bascd upon llie Dcmpstcr-Shafcr tlicory [2,p.9] arid lends ieelf to problcnis where the relationships and indepcndcnce between variablcs can be fully described. The symbolic approach may be applicable wlicn thc information provided tends to be subjective or have imprecise relationships between variables [2,p.2]. An example of this type of approach is the work done by Steven Shafer, et& in developirig a framework for sensor 360" 4352 4932 W2160234371.pdf 0 29 separator 0.85710967 ¶ 4933 4935 W2160234371.pdf 0 30 paratext 0.9068592 U.S. Government work not protected by U.S. copyright. 4935 4989 W2160234371.pdf 0 0 paratext 0.9212325 "V o l . 1 , N o . 3 International Education Studies 8qualification." 0 132 W2106149286.pdf 5 1 separator 0.9812641 ¶ 133 135 W2106149286.pdf 5 2 text 0.99953437 "•The delivery of value poses the biggest challenges to the w hole idea of the Fd provision. The inbound logistics are from largely the same background that HNs used to recru it from with a few more students coming from a widening participation background. The institutional behaviour is mixed in excitement that recruitment is aided by the support from FDF but confusing that the new provision has different demands on the mode of delivery and attitude of the student. Some of the students are difficult to motivate as they are not from academically inclined backgrounds. HEIs and FEIs are supposed to reinvent themselves in the face of new challenges posed by Fds. There is need for mutual cooperation with employers in both design and delivery of courses. But, it is do ubtful if organisations would want to continue to work FEIs and HEIs in delivering the Fds for a long st retch of time. It is not in conceivable that the FD will simply transform into a Higher Nationa l where there is no partnersh ip in design and delivery." 135 1182 W2106149286.pdf 5 3 separator 0.98442817 ¶ 1183 1185 W2106149286.pdf 5 4 text 0.99649537 In emphasizing the case for Fds Morgan et al (2004: p 359) state that: ... There had to be a clear justification for introducing a new award in place of the existing HNCs and HNDs. 1185 1364 W2106149286.pdf 5 5 separator 0.96426845 ¶ 1365 1367 W2106149286.pdf 5 6 text 0.9900595 "Principally and pragma tically these opport unities included: •Flexibility of student choice (of modules to satisfy name d Foundation degree awar ds e.g Finance, HRM, Marketing, Leisure and Tourism, reflecting existin g and emerging voca tional preferences.); •Vocational relevance emphasizing the development of work-related skills; •The opportunity to include APEL processes •The development of Modern Apprendices and NVQs, which could be used as access points The opportunity for students to continue to undertake related components of the award during traditional academic holiday periods." 1367 1984 W2106149286.pdf 5 7 separator 0.98186004 ¶ 1986 1988 W2106149286.pdf 5 8 text 0.99834406 "The Leitch report is often referred to as the sp ark for many changes in education. Below is a summary of the key objectives some of which have led to the development of the Fd. It is clear th at the desire is to increase the proportion of people with a level 4 qualification into which Fds fall into from 29% in 2005 to 40% in 2020." 1988 2328 W2106149286.pdf 5 9 separator 0.9799863 ¶ 2329 2331 W2106149286.pdf 5 10 text 0.98183537 "The Leitch report (Prosp erity for all in the global economy – world class skills ) sets four groups of targets for raising the level of adult skills in the UK by 2020. They were: " 2331 2517 W2106149286.pdf 5 11 separator 0.4468543 ¶ 2517 2518 W2106149286.pdf 5 12 text 0.87131566 For basic functional numera cy and literacy: 95% of adults, up fr om 85 and 79% respectively in 2005. 2518 2620 W2106149286.pdf 5 13 separator 0.4601629 2621 2622 W2106149286.pdf 5 14 text 0.3857485 ¶ 2622 2623 W2106149286.pdf 5 15 table 0.5652192 (1) At level 2623 2636 W2106149286.pdf 5 16 text 0.5892173 2 2636 2638 W2106149286.pdf 5 17 table 0.5065819 (e. 2638 2642 W2106149286.pdf 5 18 text 0.55026346 g 2642 2643 W2106149286.pdf 5 19 table 0.5231327 . 2643 2644 W2106149286.pdf 5 20 text 0.55445915 5 GCSE 2644 2651 W2106149286.pdf 5 21 table 0.6161957 s at grade A to C but 2651 2672 W2106149286.pdf 5 22 text 0.48345563 also 2672 2677 W2106149286.pdf 5 23 table 0.5371417 2677 2678 W2106149286.pdf 5 24 text 0.49679706 various 2678 2685 W2106149286.pdf 5 25 table 0.7018664 "vocational qualifications): 90% of adults, up from 69% in 2005. (2) At level 3: 1.9 million additional level 3 attainments over the period as well as an extra 0.5 million apprentices each year. (3) At level 4 (e.g. both university degrees as well as some professional qualifications e.g. in teaching and nursing): 40%, up from 29% in 2005. (" 2685 3042 W2106149286.pdf 5 26 bibliography 0.6387559 http://www.npi.org.uk/lites/leitch.pdf, accessed 10.07.07) 3042 3100 W2106149286.pdf 5 27 separator 0.9943973 ¶ 3101 3103 W2106149286.pdf 5 28 text 0.9867993 "Morgan et al (2004: p 354) state that: The expansion of higher education (HE) during the 19 80s and 1990s with government aspirations of a 50% participation rate (by students under the age of 30 by th e year 2010) in HE has raised a number of concerns, amongst others, about the potential un dermining of values, its relationships with society and its role in economic prosperity." 3103 3493 W2106149286.pdf 5 29 separator 0.9469381 ¶ 3496 3498 W2106149286.pdf 5 30 text 0.99601716 "In emphasizing the need to expand higher education provision in UK, the Dfes argues that: For all these reasons, we believe that our target to increase participation in higher education towards 50 per cent of those aged 18–30 by the end of the decade , linked to our wider aim to prepare 90 per cent of young people for higher education or skilled employment, is right. Moreover, since on latest estimates England currently has a participation rate for 18–30 year olds of 43 per cent, the further increase we n eed to achieve 50 per cent by 2010 is relatively modest. The chart overleaf shows how other countries compare, using the nearest comparab le OECD measure. ... We welcome the fact that an objective review of the way in which the 50 per cent ta rget is measured (the Initial Entry Rate) has just begun – led by the Office for National Statistics. Views are in vited via the National Sta tistics website until the end of February 2003. The aim is to increase the rigour and transparency of the method for measuring our progress ." 3498 4560 W2106149286.pdf 5 31 separator 0.91364974 ¶ 4560 4562 W2106149286.pdf 5 32 bibliography 0.89467895 (http://www.dfes.gov.uk/hegateway/strategy/ hestrategy/expand.shtml, accessed 13.07.07) 4562 4650 W2106149286.pdf 5 33 separator 0.9932709 ¶ 4651 4653 W2106149286.pdf 5 34 text 0.9988593 "Thse arguments by Morgan et al (2004) and the Dfes fu rther confirm assertions made in the Leitch report in emphasizing the pressures for increasing the need for highe r qualifications, ie at level 4. In view of the political statements that this action makes it is inconceivable not to be skeptical about the expansion of education provision in that it carries both a principle of development and po litical appeal no wonder Tony Blair prime minister of the UK (1997 – 2007) had his key policy centred on what he termed Education! Education! Education!" 4653 5219 W2106149286.pdf 5 0 text 0.9993451 "lung cancer [ 8,9], whereas other studies have shown that the DD genotype of ACE contributes to a higher risk of lung cancer [ 10–13]. However, another study has shown that the ACE ‘ID’genotype might increase the risk of lung cancer [ 14]. In addition, other studies have shown no association between ACE I/D polymorphism and lung cancer [ 15–19]. To more accurately assess the potential relationship between the ACE I/D polymorph- ism and the risk of lung cancer, we performed a meta- analysis using all eligible published studies." 0 550 W3119904628.pdf 1 1 separator 0.9966169 ¶ 550 552 W3119904628.pdf 1 2 title 0.9897026 Methods 552 560 W3119904628.pdf 1 3 separator 0.9103254 ¶ 560 562 W3119904628.pdf 1 4 title 0.98655564 Search strategies 562 580 W3119904628.pdf 1 5 separator 0.98585606 ¶ 580 582 W3119904628.pdf 1 6 text 0.99853504 "We conducted a comprehensive search of the literature in the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) electronic databases, covering relevant studies published as of June 31, 2019. The keywords for the search were as follows: ( “angiotensin-converting en- zyme ”OR “ACE ”)A N D( “polymorphism ”OR “variant ” OR “mutation ”) AND ( “Lung cancer ”OR “lung neo- plasm ”’). The literature on relevant data was searched in English and Chinese. In addition, retrieved articles and references were manually searched. Referring to the Pre- ferred Reporting Project (PRISMA) Guide for Systematic Evaluation and Meta-Analysis [ 20], an information flow diagram related to the final eligibility data was con- structed by screening all retrieved studies." 582 1412 W3119904628.pdf 1 7 separator 0.99679327 ¶ 1412 1414 W3119904628.pdf 1 8 title 0.9931837 Inclusion and exclusion criteria 1414 1447 W3119904628.pdf 1 9 separator 0.9942448 ¶ 1447 1449 W3119904628.pdf 1 10 text 0.9994257 "Screening for the studies of the relationship between ACE I/D polymorphism and the risk of lung cancer was performed according to the following inclusion criteria: (1) the design of the study was case –control; (2) the full text can be found; (3) the genotype information of the ACE I/D polymorphism was available; (4) therelationship of the ACE I/D polymorphism and the risk of lung cancer was evaluated. The major exclusion cri- teria were: (1) not a case –control study; (2) repeating early publications (studies used in different publications for the same sample data, including only the most complete samples after careful review); (3) unpublished articles, conference papers, meta-analysis, and systematic reviews; (4) family-based pedigree research. This meta- analysis strictly followed the requirements of PRISMA [20]." 1449 2305 W3119904628.pdf 1 11 separator 0.9970472 ¶ 2305 2307 W3119904628.pdf 1 12 title 0.99270284 Data extraction 2307 2323 W3119904628.pdf 1 13 separator 0.99471563 ¶ 2323 2325 W3119904628.pdf 1 14 text 0.9994909 "The data of the selected studies were independently ex- tracted by two researchers using standard data collection forms. The information extracted from the literature was as follows: first author, year of publication, country of origin, mean age and gender in cases and controls, num- ber of cases and controls, Hardy-Weinberg equilibrium, genotyping method, source of controls, and available genotype frequency information for ACE I/D. If the same sample data appeared in multiple publications, only publi- cations with the largest sample size were included in the study. The differences between the two investigators were resolved through discussion. If the discussion could not resolve the objection between the two researchers, the ob- jection was judged by a third investigator. All data were obtained from the full text of the published research, and the authors were not contacted for further information." 2325 3268 W3119904628.pdf 1 15 separator 0.96303713 ¶ 3268 3270 W3119904628.pdf 1 16 text 0.92322403 "All information on the participants in the selected studies is presented in Table 1." 3270 3357 W3119904628.pdf 1 17 separator 0.9950908 ¶ 3357 3359 W3119904628.pdf 1 18 title 0.9920728 Study quality assessment 3359 3384 W3119904628.pdf 1 19 separator 0.99154913 ¶ 3384 3386 W3119904628.pdf 1 20 text 0.9989827 "Two evaluators evaluated the quality of the included studies according to the Newcastle-Ottawa Scale (NOS) [22], which is applicable to the quality assessment of ob- servational studies. The difference between the two" 3386 3610 W3119904628.pdf 1 21 separator 0.99396914 ¶ 3610 3612 W3119904628.pdf 1 22 title 0.88621026 Table 1 Characteristic of studies included in the meta-analysis 3612 3676 W3119904628.pdf 1 23 table 0.9230517 "¶ Author year country Ethnicity Age group Genotype MethodsSource of control NOS score HWE Pe" 3676 3773 W3119904628.pdf 1 24 bibliography 0.57079166 ddireddy et al [ 3773 3789 W3119904628.pdf 1 25 table 0.5527423 14] 2018 3789 3798 W3119904628.pdf 1 26 bibliography 0.5191218 South Indian Asia 3798 3816 W3119904628.pdf 1 27 table 0.7291316 Adult PCR PB 8 0.726 ¶ 3816 3839 W3119904628.pdf 1 28 bibliography 0.6670855 Phukan et al [ 9] 2014 Northeast India Asia Adult PCR 3839 3893 W3119904628.pdf 1 29 table 0.6043061 PB 8 0.227 3893 3904 W3119904628.pdf 1 30 separator 0.46017498 ¶ 3904 3906 W3119904628.pdf 1 31 bibliography 0.67459595 Ozen et al [ 16] 2013 Turkey Caucasians Adult PCR 3906 3956 W3119904628.pdf 1 32 table 0.58275944 PB 7 0.920 3956 3967 W3119904628.pdf 1 33 separator 0.41464487 3967 3968 W3119904628.pdf 1 34 table 0.41853812 ¶ 3968 3969 W3119904628.pdf 1 35 bibliography 0.76183206 Shi et al [ 12] 2014 China Asia Adult PCR-SSP PB 6 3969 4020 W3119904628.pdf 1 36 table 0.5254966 0.308 4020 4026 W3119904628.pdf 1 37 separator 0.50209314 ¶ 4026 4028 W3119904628.pdf 1 38 bibliography 0.78895533 Cheon et al [ 15] 2000 Korea Asia Adult PCR – 6 0.133 4028 4082 W3119904628.pdf 1 39 separator 0.42255157 ¶ 4082 4084 W3119904628.pdf 1 40 bibliography 0.7887595 Yaren et al [ 17] 2008 Turkey Caucasians Adult PCR – 7 4084 4139 W3119904628.pdf 1 41 table 0.48502824 0.470 4139 4145 W3119904628.pdf 1 42 separator 0.3861432 ¶ 4145 4147 W3119904628.pdf 1 43 bibliography 0.8525058 Nacak et al [ 8] 2010 Turkey Caucasians Adult PCR PB 8 0.268 4147 4208 W3119904628.pdf 1 44 separator 0.776613 ¶ 4208 4210 W3119904628.pdf 1 45 bibliography 0.89239615 Wang et al [ 13,21] 2000 China Asia Adult PCR – 6 0.861 4210 4266 W3119904628.pdf 1 46 separator 0.43213966 4266 4267 W3119904628.pdf 1 47 bibliography 0.84621304 ¶ Zhang et al [ 18] 2005 China Asia Adult PCR HB 7 0.109 4267 4323 W3119904628.pdf 1 48 separator 0.45545718 ¶ 4323 4325 W3119904628.pdf 1 49 bibliography 0.92969537 Gao et al [ 11] 2012 China Asia Adult PCR HB 6 0.018 4325 4378 W3119904628.pdf 1 50 separator 0.6609285 ¶ 4378 4380 W3119904628.pdf 1 51 bibliography 0.9716205 Devic Pavlic et al [ 10] 2012 Croatia Caucasians Adult PCR HB 7 0.909 4380 4450 W3119904628.pdf 1 52 separator 0.79237914 ¶ 4450 4452 W3119904628.pdf 1 53 bibliography 0.9758077 Ding et al [ 19] 2008 China Asia Adult PCR HB 7 0.175Chen et al. BMC Cancer (2021) 21:15 4452 4550 W3119904628.pdf 1 54 paratext 0.96990144 8 Page 2 of 9 4550 4563 W3119904628.pdf 1 0 paratext 0.98460066 "7 Scientific RepoRtS | (2020) 10:4939 | https://doi.org/10.1038/s41598-020-61893-4 www.nature.com/scientificreports www.nature.com/scientificreports/" 0 162 W3011567797.pdf 6 1 separator 0.99672055 ¶ 162 164 W3011567797.pdf 6 2 caption 0.98559916 "Figure 4. Case vignette of a 48-year old female former gymnast (BMI 27.6 kg/m2; ASA 2), who underwent uneventful L4-S1 single-stage anterior lumbar interbody fusion and posterior spinal fusion for intractable low back pain and bilateral lower extremity pain (left > right) due to degenerative disc disease at L4-S1 with grade-1 isthmic spondylolisthesis at L5-S1 (ODI 48). (a) Preoperative sagittal T2-weighted MRI. (b) Preoperative long- cassette x-ray show a high pelvic incidence of 70° and a lumbar lordosis (LL) of 62° with preserved sagittal vertical alignment (SV A) of +3.5 cm. (c)" 164 768 W3011567797.pdf 6 3 text 0.97519433 "Individual activity data is illustrated over time, from 30 days before the day of surgery (DOS), over postoperative weeks (W) 1, 2, 4, 8, 12 (M3), 26 and 52 (Y1). At her M3 follow-up visit the patient reports being 95% better compared to preoperative (ODI 12) and her standing x-rays are unremarkable. At her Y1 follow-up visit, she reports new onset of mild low back pain and some left-sided leg pain, translating into lesser activity and mild increase in the ODI (18). (d) The MRI at Y1 shows a solid fusion at the L4-S1 levels with adjacent segment disease, mild disc protrusion and facet disease at L3-4. The patient improved after additional epidural steroid injection at the L3-4 level and so far no additional surgical treatment was required. (e) Post-operative long-cassette x-ray show a LL of 72°, SV A of +1 cm." 768 1596 W3011567797.pdf 6 4 separator 0.99619865 ¶ 1596 1598 W3011567797.pdf 6 5 caption 0.9945263 "Figure 5. A 33-year old male patient (BMI 26.2 kg/m2; ASA 2) underwent an uneventful right L5/S1 microdiscectomy for right S1-lumboradicular pain resulting from LDH and non-responsive to conservative management (ODI 50). (a,b) Preoperative sagittal (a) and axial (b) T2-weighted MRI. (c) Individual activity data is illustrated over time, from 30 days before the day of surgery (DOS), over postoperative weeks (W) 1, 2, 4, 8, 12 (M3) and 26." 1598 2043 W3011567797.pdf 6 6 text 0.99869925 "Initially, he experienced complete resolution of his symptoms. After a decrease in the activity level at the 1 st postoperative week, he was able to regain (2nd week) and almost double his baseline activity at the 4th week. He then carried a 5-gallon (40-50lbs) jug of paint about seven weeks postoperative and noted new onset of low back and right-sided leg pain with a new plantarflexion weakness (*). A repeat MRI was consistent with a re-herniated right paramedian L5/S1 LDH (d) sagittal view; (e) axial view). The patient underwent repeat surgery (S) about 14 weeks after the initial surgery. The M3 ODI was 48 and the Y1 ODI 36. The patient decided against further objective step count measurements for this study beyond 217 days postoperative." 2043 2808 W3011567797.pdf 6 0 paratext 0.76353174 Effects of dietar y lysine le vel on gr owing pig per formance (1989) 0 70 W2279445833.pdf 1 1 title 0.71379834 Effects of dietar y lysine le vel on gr owing pig per formance 70 132 W2279445833.pdf 1 2 paratext 0.52868557 (1989) 132 139 W2279445833.pdf 1 3 separator 0.99590886 ¶ 140 142 W2279445833.pdf 1 4 contact 0.73613036 Authors Authors 142 158 W2279445833.pdf 1 5 separator 0.8766606 ¶ 159 161 W2279445833.pdf 1 6 contact 0.9473514 D F. Li, M E. Johnst on, Jim L. Nelssen, and Rober t D. Goodband 161 226 W2279445833.pdf 1 7 separator 0.9913666 ¶ 227 229 W2279445833.pdf 1 8 text 0.9880668 This r esear ch repor t is a vailable in Kansas Agricultur al Experiment Station Resear ch Repor ts: 229 330 W2279445833.pdf 1 9 separator 0.93275285 ¶ 331 333 W2279445833.pdf 1 10 bibliography 0.5026747 https:/ / 333 343 W2279445833.pdf 1 11 paratext 0.430416 new 343 346 W2279445833.pdf 1 12 bibliography 0.45037585 pr air 346 352 W2279445833.pdf 1 13 paratext 0.3266373 iepr 352 356 W2279445833.pdf 1 14 bibliography 0.47736266 es 356 359 W2279445833.pdf 1 15 paratext 0.3264629 s 359 360 W2279445833.pdf 1 16 bibliography 0.3911135 .or g/ 360 366 W2279445833.pdf 1 17 paratext 0.31625614 kaesrr/v 366 374 W2279445833.pdf 1 18 bibliography 0.4644563 ol 374 377 W2279445833.pdf 1 19 paratext 0.37599242 0/iss10/452 377 388 W2279445833.pdf 1 0 paratext 0.9488675 JHEP01(2019)014Contents 0 23 W3105026288.pdf 1 1 separator 0.9939805 ¶ 23 25 W3105026288.pdf 1 2 title 0.85619926 1 Introduction 1 25 42 W3105026288.pdf 1 3 separator 0.93732697 ¶ 42 44 W3105026288.pdf 1 4 title 0.94843507 2 't Hooft anomaly matching condition 2 44 84 W3105026288.pdf 1 5 separator 0.95837265 ¶ 84 86 W3105026288.pdf 1 6 title 0.6884777 2.1 Setup 86 96 W3105026288.pdf 1 7 table 0.7024128 "2 2.2" 96 104 W3105026288.pdf 1 8 title 0.64149654 Chiral symmetry 104 120 W3105026288.pdf 1 9 table 0.698852 "3 2.3 Center symmetry 4 2.4 '" 120 154 W3105026288.pdf 1 10 title 0.5018614 t Hooft 154 161 W3105026288.pdf 1 11 table 0.4726764 anomal 161 168 W3105026288.pdf 1 12 title 0.51508224 y 168 169 W3105026288.pdf 1 13 table 0.75116324 "5 2.5" 169 177 W3105026288.pdf 1 14 title 0.5002217 Domain-wall 177 189 W3105026288.pdf 1 15 table 0.5527003 7 189 191 W3105026288.pdf 1 16 separator 0.9934275 ¶ 191 193 W3105026288.pdf 1 17 title 0.95129555 3 Example of chiral symmetry breaking without bilinear condensate 7 193 261 W3105026288.pdf 1 18 separator 0.9837899 ¶ 261 263 W3105026288.pdf 1 19 table 0.7021979 "3.1 Example 7 3.2 Con nement 8 3.3 No fermion bilinear 8" 263 324 W3105026288.pdf 1 20 separator 0.99012244 ¶ 324 326 W3105026288.pdf 1 21 title 0.94329596 4 Summary and discussion 9 326 353 W3105026288.pdf 1 22 separator 0.9963554 ¶ 353 355 W3105026288.pdf 1 23 title 0.9770613 1 Introduction 355 370 W3105026288.pdf 1 24 separator 0.99399626 ¶ 370 372 W3105026288.pdf 1 25 text 0.9995383 "'t Hooft anomaly matching condition [ 1] is a powerful tool to investigate the phase structure of strongly coupled quantum eld theories. Since the 't Hooft anomaly is invariant under the renormalization group ow, it often strongly constrains the vacuum structure and the low energy eective theory. 't Hooft anomaly matching condition of discrete symmetry has also been shown to be useful [ 2]." 372 777 W3105026288.pdf 1 26 separator 0.88354063 ¶ 777 779 W3105026288.pdf 1 27 text 0.99971414 "Recently it has been shown in [ 3, 4] that 't Hooft anomaly matching including higher form symmetries is also powerful. In particular the center symmetry of the gauge theory, a typical example of a 1-form symmetry, and its twist are related to con nement; the con ning phase is characterized by the absence of spontaneous breaking of the center symmetry. Therefore by considering the mixed 't Hooft anomaly of the center symmetry, one may nd constraints of the phase structure of the theory in the con ning phase. There has been interesting progress along this line [ 5{21]." 779 1367 W3105026288.pdf 1 28 separator 0.9852754 ¶ 1367 1369 W3105026288.pdf 1 29 text 0.9994177 "In this paper we investigate a 4-dimensional SU( N) gauge theory with a Weyl fermion in an irreducible self-conjugate representation R. The U(1) phase rotation of the fermion in this theory is broken to Z`;(`: Dynkin index of R) due to the anomaly [ 22, 23]. We call this Z`symmetry the \chiral symmetry."" In addition, this theory has the Zqcenter symmetry, where q:= gcd(N;c) andcis theN-ality ofR. We check the mixed 't Hooft anomaly between the chiral symmetry and the center symmetry, and obtain constraints on the spontaneous breaking of the chiral symmetry under the assumption of con nement. In" 1369 1983 W3105026288.pdf 1 30 separator 0.9441247 ¶ 1983 1985 W3105026288.pdf 1 31 math 0.5783694 { 1 { 1985 1991 W3105026288.pdf 1 0 title 0.99329793 Luciferase reporter assay 0 25 W3005331653.pdf 10 1 separator 0.99538195 ¶ 25 27 W3005331653.pdf 10 2 text 0.9993805 "HEK293T cells were transfected with the pGL3 basic luciferase plasmid (Promega) containing the T-bet promoter alone or the T-bet promoter in combination with an upstream enhancer region (Yang et al., 2007 ), or the empty pGL3 basic in combination with an internal control pRL-TK Renilla plasmid (Promega). The T-bet enhancer/promoter plasmid was described before ( Hosokawa et al., 2013 ) and kindly provided by H. Hosokawa (Tokai University, Japan). In order to assess gene regula- tion by c-Maf, putative Maf responsive elements in the promoter and enhancer were mutated using the Q5 Site-Directed Mutagenesis Kit (New England Biolabs). In addition to mutated reporter plas- mids, cells were co-transfected with c-Maf coding sequence in pMSCV. Luciferase activity was mea- sured on a SpectraMax i33 microplate reader (Molecular Devices) after 24 hr using dual luciferase assay system (Promega). Luciferase activity was determined relative to Renilla." 27 998 W3005331653.pdf 10 3 separator 0.99723756 ¶ 998 1000 W3005331653.pdf 10 4 title 0.99268657 In vitro stimulation of NKp46+CCR6-ILC3s with cytokines 1000 1056 W3005331653.pdf 10 5 separator 0.9911748 ¶ 1056 1058 W3005331653.pdf 10 6 text 0.99849623 "CD45+Lineage-(Lineage: anti-CD19, anti-Gr-1, anti-CD3, anti-CD5) ROR gtfm+CD127+NKp46+ CCR6-cells were sort-purified from the siLP of 11–14 week old RorcCreR26EYFPmice. Sorted cells were transferred in complete RPMI medium to a 96 U bottom well plate at a density of 15.000 cells/ well. Subsequently cells were cultured in the presence of IL-7 (20 ng/ml) and SCF (20 ng/ml) plus dif- ferent cytokines (IL-1ß, IL-12, IL-15, IL-18, IL-23; each at 20 ng/ml) for 36 hr before mRNA analysis." 1058 1553 W3005331653.pdf 10 7 separator 0.9235751 ¶ 1553 1555 W3005331653.pdf 10 8 text 0.99911153 "For blocking NF- kb activation, BMS-345541, a selective inhibitor of I kB kinase ( Burke et al., 2003 ), was added at a concentration of 1 mM to the culture." 1555 1715 W3005331653.pdf 10 9 separator 0.99679023 ¶ 1715 1717 W3005331653.pdf 10 10 title 0.99285 In vitro culture of NKp46+CCR6-ILC3s on OP9-DLL1 cells 1717 1772 W3005331653.pdf 10 11 separator 0.99069977 ¶ 1772 1774 W3005331653.pdf 10 12 text 0.9987795 "CD45+Lineage-(Lineage: anti-CD19, anti-Gr-1, anti-CD3, anti-CD5) ROR gtfm+CD127+NKp46+ CCR6-cells were sort-purified from the siLP of 11–14 week old RorcCreR26EYFPmice. Sorted cells were transferred in complete RPMI medium to OP9 or OP9-DLL1 cells at a density of 10.000 cells/ well and cultured in the presence of IL-7 (20 ng/ml) and SCF (20 ng/ml) for 12 days before flow cyto- metric analysis. OP9 cells are murine stromal cells derived from OP/OP mice used as feeder cells in lymphocyte differentiation assays. OP9-DLL1 cells are transfected with Notch ligand delta-like-1 (Schmitt and Zu ́n ̃iga-Pflu ̈cker, 2002 ). Prior to adding isolated lymphocytes, confluent feeder cells were treated with 5 mg/ml Mitomycin C (Sigma) for 3 hr at 37 ̊C and subsequently seeded on a 96 flat bottom well plate at a density of 50.000 cells/well." 1774 2625 W3005331653.pdf 10 13 separator 0.9970005 ¶ 2625 2627 W3005331653.pdf 10 14 title 0.9924696 Bone marrow chimeras 2627 2648 W3005331653.pdf 10 15 separator 0.995764 ¶ 2648 2650 W3005331653.pdf 10 16 text 0.9992942 "Bone marrow cells from wild-type CD45.1+CD90.2+C57BL/6 and CD45.2+CD90.2+RorcCreMaffl/fl mice were mixed in a 1:1 ratio and intravenously injected into sub-lethally irradiated CD90.1+wild- type recipient mice. Small and colonic lamina propria of reconstituted mice were analysed 6 weeks after cell transfer." 2650 2964 W3005331653.pdf 10 17 separator 0.9954716 ¶ 2964 2966 W3005331653.pdf 10 18 title 0.98963815 qPCR 2966 2971 W3005331653.pdf 10 19 separator 0.99389017 ¶ 2971 2973 W3005331653.pdf 10 20 text 0.99942935 "mRNA for real-time qPCR was isolated with the RNeasy Plus Micro Kit according to the manual of the manufacturer (QIAGEN). Reverse transcription was done with the High Capacity cDNA Reverse Transcription Kit (Applied Biosystems) as it is described in the manufacturer’s protocol. qPCR was performed using a Quant Studio five system (Applied Biosystems) and the SYBR Green PCR Master Mix Kit (Applied Biosystems). The mRNA expression is presented relative to the expression of the housekeeping gene hypoxanthine-guanine phosphoribosyl-transferase (HPRT). Real-time qPCR primer can be found in Supplementary file 4 ." 2973 3599 W3005331653.pdf 10 21 separator 0.99697936 ¶ 3599 3601 W3005331653.pdf 10 22 title 0.9924838 Statistical analysis 3601 3622 W3005331653.pdf 10 23 separator 0.9946418 ¶ 3622 3624 W3005331653.pdf 10 24 text 0.9995052 "Data are the mean with SEM and summarize or are representative of independent experiments as specified in the text. Statistical analyses were performed using Prism software (GraphPad) with two- tailed unpaired Student’s ttest (except RNA-seq data)." 3624 3877 W3005331653.pdf 10 25 separator 0.96791065 ¶ 3877 3879 W3005331653.pdf 10 26 paratext 0.92882127 Tizian et al. eLife 2020;9:e52549. DOI: https://doi.org/10.7554/eLife.52549 11 of 17Short report Immunology and Inflammation 3879 4004 W3005331653.pdf 10 0 paratext 0.98632574 Page 19/22 0 10 W4310992513.pdf 18 0 paratext 0.8504579 Mu et al. 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Scatter chart of the efforts of the sprayer pumping lever tested with water. 166 255 W2807520881.pdf 5 5 separator 0.98362446 ¶ ¶ 257 263 W2807520881.pdf 5 6 text 0.9994755 "In general, the results demonstrate that the “A” Sprayer required more effort for the return activation (17.46 N). The “D” sprayer required a higher activation effort for both before and after reaching the pressure at 300 kPa, being 69.33 N, 108.56 N, resp ectively. The “E” Sprayer was the least intense in relation to the average activation effort to obtain the pressure of 300 kPa (10.10 N).The “A” Sprayer was the most regular and least intense in relation to the average activation effort to maintain the pressure of 300 kPa (26.73 N), besides requiring a smaller amount of activation cycles of the pumping lever to reach the work pressure." 263 945 W2807520881.pdf 5 7 separator 0.9838468 ¶ 947 949 W2807520881.pdf 5 8 text 0.99942166 "Although we obtained only one bibliographical reference that could make the comparisons of the results and despite of this reference being very old, it was observed that the results were very similar to those found by Phadke et al. (1992).Therefore, the application of the proposed methodology proved to be efficient, easy and of low cost, so that further studies could be done to provide data for the analysis of the ergonomic working conditions of sprayers and other manual activation lever." 949 1468 W2807520881.pdf 5 9 separator 0.99442756 ¶ ¶ 1470 1476 W2807520881.pdf 5 10 title 0.9903237 CONCLUS IONS 1476 1489 W2807520881.pdf 5 11 separator 0.996077 ¶ 1491 1493 W2807520881.pdf 5 12 text 0.99897444 "The employed methodology was adequate to measure the operator’s upward and downward effort required for the operation of knapsa ck hand sprayers." 1493 1645 W2807520881.pdf 5 13 separator 0.66605467 ¶ 1646 1648 W2807520881.pdf 5 14 text 0.99951655 "Considering the Brazilian laws, CLT - Law no. 6,514, all sprayers obtained satisfactory results, i.e. with effort values below the expected limit. However, only “A” and “E” sprayers obtained satisfactory results for the international indi cations (NASA -STD -3000B) for manual activation lever." 1648 1958 W2807520881.pdf 5 15 separator 0.9871752 ¶ ¶ 1960 1966 W2807520881.pdf 5 16 title 0.9295065 REFERENCES 1966 1977 W2807520881.pdf 5 17 separator 0.9921119 ¶ 1979 1981 W2807520881.pdf 5 18 bibliography 0.99703526 "França JAL, Gonçalves WS, Romeiro BP, Benett CGS, Silva AR (2015) Desenvolvimento e avaliação de um pulverizador hidráulico de barras rígidas horizontais de baixo custo. Revista de Agricultu ra Neotropical 2(1):17 - 23." 1981 2212 W2807520881.pdf 5 19 separator 0.8705209 "¶ ¶" 2213 2223 W2807520881.pdf 5 20 bibliography 0.9973137 "Freitas CS (2006) Análise ergonômica da atividade com pulverizador costal manual na cultura do café no município de Caratinga. 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Immunopharmacol Immunotoxicol 16: 319–346." 7729 7861 W2034547974.pdf 9 73 separator 0.9301332 ¶ 7861 7863 W2034547974.pdf 9 74 bibliography 0.99549013 "74. Murk W, Atabekoglu CS, Cakmak H, Heper A, Ensari A, et al. (2008) Extracellularly signal-regulated kinase activity in the human endometrium: possible roles in the pathogenesis of endometriosis. J Clin Endocrinol Metab 93: 3532–3540.ISO-1 as a Potential Treatment of Endometriosis" 7863 8153 W2034547974.pdf 9 75 separator 0.93966675 ¶ 8153 8155 W2034547974.pdf 9 76 paratext 0.9790758 PLoS ONE | www.plosone.org 10 May 2012 | Volume 7 | Issue 5 | e37264 8155 8224 W2034547974.pdf 9 0 paratext 0.607848 University, Jiangsu, People ’s Republic of China.3 0 50 W2903690102.pdf 5 1 contact 0.6442674 "West China School of Medicine, West China Hospital, Sichuan University, Chengdu 610041, People ’s Republic of China.4West China Hospital, Chengdu 610041, People" 50 214 W2903690102.pdf 5 2 paratext 0.6559485 "’s Republic of China." 214 238 W2903690102.pdf 5 3 separator 0.9400681 ¶ 238 240 W2903690102.pdf 5 4 paratext 0.98330927 Received: 4 May 2018 Accepted: 4 December 2018 240 287 W2903690102.pdf 5 5 separator 0.9768717 ¶ 287 289 W2903690102.pdf 5 6 title 0.61755526 References 289 300 W2903690102.pdf 5 7 separator 0.9872594 ¶ 300 302 W2903690102.pdf 5 8 bibliography 0.9978165 "1. 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BMC Cancer (2018) 18:1272" 6194 6398 W2903690102.pdf 5 73 paratext 0.97136104 Page 6 of 6 6398 6410 W2903690102.pdf 5 0 table 0.50996023 (1) What 0 8 W2939644726.pdf 6 1 text 0.5356599 is important to students? 8 34 W2939644726.pdf 6 2 table 0.56282246 ¶ (2) 34 40 W2939644726.pdf 6 3 text 0.7103996 How far do students experience what is important to them? 40 98 W2939644726.pdf 6 4 table 0.6643069 ¶ 98 100 W2939644726.pdf 6 5 text 0.7631808 (3) How big a gap is there between what they value and what they experience? 100 177 W2939644726.pdf 6 6 separator 0.9934011 ¶ 177 179 W2939644726.pdf 6 7 text 0.9984852 "The sequence in which the items appear within any one construct is randomised for each participant, and people are asked to rate each of them on two 6-point Likert scales. At the end of each construct section, respondents are given the opportunity to add any open comments if they wish." 179 472 W2939644726.pdf 6 8 separator 0.9801334 ¶ 472 474 W2939644726.pdf 6 9 text 0.99931496 "The importance scale (IMP) reveals what is important to students —both the importance of the constructs (e.g. SI and AI) and the individual items that are particularly important to them." 474 663 W2939644726.pdf 6 10 separator 0.6248514 ¶ 663 665 W2939644726.pdf 6 11 text 0.9992115 "The higher the importance scores are, the greater the students ’aspirations are for a global education experience. As explained above, this attitudinal element is an important prerequisite for personal growth." 665 879 W2939644726.pdf 6 12 separator 0.9548712 ¶ 879 881 W2939644726.pdf 6 13 text 0.999408 "The experience scale (EXP) reveals what respondents feel they are actually experiencing with respect to each of the five constructs. As also explained above, experiences of difference are the other important foundation for personal growth. High diversity experience scores are another indicator of an enriching context. The higher the experience scores are, the greater are students ’opportunities for/engagement with aglobal education experience" 881 1336 W2939644726.pdf 6 14 separator 0.9811952 ¶ 1336 1338 W2939644726.pdf 6 15 text 0.99958825 "Reliability scores were obtained for each scale (IMP and EXP) for all constructs, and all were extremely high (Cronbach ’sα> 0.85). In addition, confirmatory factor analysis was performed separately for each of the IMP and EXP scales for each construct, which further c o r r o b o r a t e dt h es t a b i l i t yo ft h ec h o s e nc o n s t r u c t s( R M S E A IMP=0 . 0 6 ,R M S E A EXP= 0.06)." 1338 1742 W2939644726.pdf 6 16 separator 0.9880943 ¶ 1742 1744 W2939644726.pdf 6 17 text 0.9996915 "Naturally, the results from the GEP can be reported as mean scores (per construct and/or per item), but another helpful way is to display them on a matrix. When the two scales (IMP and EXP) are combined, with cut-off points halfway on each scale, they yield four quadrants that provide an overview picture of the diversity engagement context. When people ’sI M Pa n d EXP scores are both high, this is the most positive situation and so this quadrant is labelled ‘flourishing ’.W h e np e o p l e ’s IMP scores are high but the EXP scores are low, this is a problematic situation because of the failure to meet people ’s expectations/desires, and so this quadrant is labelled ‘unfulfilling ’.W h e np e o p l e ’s IMP scores are low but EXP scores are high, the context is positive in terms of actual experiences, but people ’s aspirations are low. This quadrant is labelled ‘nurturing ’. The fourth quadrant is the most problematic in terms of developing ‘global graduates ’because students not only attach low levels of importance to it but also experience it very little. This quadrant is labelled ‘limiting ’.F i g u r e 1illustrates these different perceptual contexts. In our analyses, chi-squared tests with Yates ’continuity correc- tion were used to probe the statistical significance of differences within each quadrant of participants ’IMP and EXP ratings." 1744 3140 W2939644726.pdf 6 18 separator 0.9892532 ¶ 3140 3142 W2939644726.pdf 6 19 text 0.9970796 It is important to mention that these are different measures from student satisfaction. 3142 3230 W2939644726.pdf 6 20 separator 0.79898334 ¶ 3230 3232 W2939644726.pdf 6 21 text 0.99973935 "Participants are not asked to rate the quality of the experience, but ‘how much/little ’they experience certain aspects of their university life. Thus, conceptually, these scales are different from commonly used Likert-scales which ask participants to rate their satisfaction with different aspects of their campus life. However, by combining the IMP and EXP scores it is possible to gain insights into their level of satisfaction, but with a more differentiated perspective into the bases of their ratings. This is because if satisfaction is high, it is actually unclear whether their satisfaction is because they regard the particular feature as important and are genuinely experiencing it (and would fall into the flourishing quadrant) or because they do not care about whether they experience it or not (and thus fall into the limiting quadrant)." 3232 4099 W2939644726.pdf 6 22 paratext 0.9889213 InHigher Education (2019) 78:1035 –1058 1041 4099 4144 W2939644726.pdf 6 0 paratext 0.9643771 "Citation: Alghamdi, A.S. Optimal Power Flow of Hybrid Wind/Solar/Thermal Energy Integrated Power Systems Considering Costs and Emissions via a Novel and Efficient Search Optimization Algorithm. Appl. Sci. 2023 ,13, 4760. https://doi.org/ 10.3390/app13084760" 0 272 W4364375030.pdf 0 1 separator 0.9813427 ¶ 272 274 W4364375030.pdf 0 2 contact 0.93813276 "Academic Editors: Marcos Tostado-V éliz, Abd Elnaby Kabeel and Salah Kamel ¶" 274 355 W4364375030.pdf 0 3 paratext 0.9411455 "Received: 12 March 2023 Revised: 1 April 2023 Accepted: 4 April 2023 Published: 10 April 2023" 355 455 W4364375030.pdf 0 4 separator 0.57475877 ¶ 455 457 W4364375030.pdf 0 5 paratext 0.9554679 "Copyright: © 2023 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)." 457 723 W4364375030.pdf 0 6 separator 0.7220474 ¶ 723 725 W4364375030.pdf 0 7 paratext 0.83460784 "applied sciences" 725 746 W4364375030.pdf 0 8 separator 0.5410061 ¶ 747 749 W4364375030.pdf 0 9 paratext 0.54876316 Article 749 757 W4364375030.pdf 0 10 separator 0.57188594 ¶ 757 759 W4364375030.pdf 0 11 title 0.93014777 "Optimal Power Flow of Hybrid Wind/Solar/Thermal Energy Integrated Power Systems Considering Costs and Emissions via a Novel and Efficient Search Optimization Algorithm" 759 930 W4364375030.pdf 0 12 separator 0.9856616 ¶ 930 932 W4364375030.pdf 0 13 contact 0.9934875 "Ali S. Alghamdi Department of Electrical Engineering, College of Engineering, Majmaah University, Al-Majmaah 11952, Saudi Arabia; aalghamdi@mu.edu.sa" 932 1086 W4364375030.pdf 0 14 separator 0.99336207 ¶ 1086 1088 W4364375030.pdf 0 15 text 0.99933726 "Abstract: The OPF problem has significant importance in a power system’s operation, planning, economic scheduling, and security. Today’s electricity grid is rapidly evolving, with increased penetration of renewable power sources (RPSs). Conventional optimal power flow (OPF) has non- linear constraints that make it a highly non-linear, non-convex optimization problem. This complex problem escalates further with the integration of renewable energy resource (RES), which are generally intermittent in nature. This study suggests a new and effective improved optimizer via a TFWO algorithm (turbulent flow of water-based optimization), namely the ITFWO algorithm, to solve non-linear and non-convex OPF problems in energy networks with integrated solar photovoltaic (PV) and wind turbine (WT) units (being environmentally friendly and clean in nature). OPF in the energy networks is an optimization problem proposed to discover the optimal settings of an energy network. The OPF modeling contains the forecasted electric energy of WT and PV by considering the voltage value at PV and WT buses as decision parameters. Forecasting the active energy of PV and WT units has been founded on the real-time measurements of solar irradiance and wind speed. Eight scenarios are analyzed on the IEEE 30-bus test system in order to determine a cost-effective schedule for thermal power plants with different objectives that reflect fuel cost minimization, voltage profile improvement, emission gases, power loss reduction, and fuel cost minimization with consideration of the valve point effect of generation units. In addition, a carbon tax is considered in the goal function in the examined cases in order to investigate its effect on generator scheduling. A comparison of the simulation results with other recently published algorithms for solving OPF problems is made to illustrate the effectiveness and validity of the proposed ITFWO algorithm. Simulation results show that the improved turbulent flow of water-based optimization algorithm provides an effective and robust high-quality solution of the various optimal power-flow problems. Moreover, results obtained using the proposed ITFWO algorithm are either better than, or comparable to, those obtained using other techniques reported in the literature. The utility of solar and wind energy in scheduling problems has been proposed in this work." 1088 3524 W4364375030.pdf 0 16 separator 0.989546 ¶ 3524 3526 W4364375030.pdf 0 17 paratext 0.4201774 Keywords: 3526 3536 W4364375030.pdf 0 18 text 0.45568216 power 3536 3542 W4364375030.pdf 0 19 paratext 0.32426775 systems operation 3542 3560 W4364375030.pdf 0 20 text 0.31989965 ; meta 3560 3566 W4364375030.pdf 0 21 paratext 0.30794677 heur 3566 3570 W4364375030.pdf 0 22 title 0.26049814 istic 3570 3575 W4364375030.pdf 0 23 text 0.33627516 algorithm; renewable energy resources; 3575 3615 W4364375030.pdf 0 24 paratext 0.37539726 ¶ 3615 3616 W4364375030.pdf 0 25 text 0.35011306 optimization 3616 3629 W4364375030.pdf 0 26 paratext 0.3376474 ; 3629 3630 W4364375030.pdf 0 27 text 0.35402736 green 3630 3636 W4364375030.pdf 0 28 paratext 0.46100003 house gas emissions 3636 3655 W4364375030.pdf 0 29 separator 0.99659467 ¶ 3655 3657 W4364375030.pdf 0 30 title 0.98217255 1. Introduction 3657 3673 W4364375030.pdf 0 31 separator 0.99126565 ¶ 3673 3675 W4364375030.pdf 0 32 title 0.9774726 1.1. Motivation 3675 3691 W4364375030.pdf 0 33 separator 0.9934849 ¶ 3691 3693 W4364375030.pdf 0 34 text 0.99544597 "The optimal power flow (OPF) is an optimization method to minimize a specific optimization benchmark while satisfying security, physical and feasibility limits. The various OPF problems have been broadly applied in recent studies, and have served as a multi-model, non-linear, and non-convex optimization problem [ 1,2]. In the last two decades, various OPF objective functions had a grandness due to the quick adoption of divided power resources in an energy network [ 3]. The accretion of divided and periodic renewable power sources (RPSs), as with wind energy (WE) and photovoltaic (PV) systems, ¶" 3693 4305 W4364375030.pdf 0 35 paratext 0.6416758 Appl 4305 4310 W4364375030.pdf 0 36 text 0.84329605 . 4310 4311 W4364375030.pdf 0 37 paratext 0.9832822 Sci. 2023 ,13, 4760. https://doi.org/10.3390/app13084760 https://www.mdpi.com/journal/applsci 4311 4405 W4364375030.pdf 0 0 text 0.9997001 "In response to exposure of ZnO nanoparticles for 4hrs significant reduction percentage of cell survival was observed against all bacteria (p /C200.005). The lethal effect of ZnO was most effective against C.jejuni and least effective V.cholerae as indicated by decrease in viable cell to 35% and 67% respectively on among all tested bacteria ( Fig 6 )." 0 358 W2403859484.pdf 6 1 separator 0.99294984 ¶ 358 360 W2403859484.pdf 6 2 text 0.9996121 "The Effects of ZnO nanoparticles on cellular morphology of E.coliandS.aureus were exam- ined by SEM. The SEM micrographs of both control and treated E.coliand S.aureus cells are shown in Fig 7 . As shown in Fig 7A and 7C untreated E.coliand S.aureus showed intact cells and normal morphology i.e., rod-shaped and round-shaped, respectively. After exposure to ZnO nanoparticles for 4 h, the irregular cell surface and leakage of cell was observed in case ofE.coli(Fig 7B ) was and whereas in case of S.aureus leakage of cellular components in some cells was observed as highlighted in Fig 7D . Together these survival assay and SEM results sug- gest that the ZnO NPs not only induced changes in cellular morphology but also cause a lethaleffect against the tested bacteria." 360 1145 W2403859484.pdf 6 3 separator 0.9892894 ¶ 1145 1147 W2403859484.pdf 6 4 text 0.99975777 "There are many proposed mechanisms for ZnO NPs action against bacteria. For example, nanoparticles attachment to bacterial cell wall via hydrophobic, electrostatic, and receptor- ligand interactions and van der waals forces which leads to cellular damage and eventual death.Also, ZnO NPs generate reactive oxygen species such as H 2O2. There is an interaction between cell membrane and H 2O2. It has an influence on cell physiological activities by interacting with the cell membrane bilayer and influencing integrity, membrane fluidity, and lateral organiza-tion [ 30,34–36]. These potential effects can be some of the reasons for NPs cytotoxicity." 1147 1807 W2403859484.pdf 6 5 separator 0.985389 ¶ 1807 1809 W2403859484.pdf 6 6 text 0.99971336 "There are many proposed interaction mechanisms of ZnO NPs to bacterial cells, as men- tioned earlier. Important bacterial biomolecules can also adsorb on ZnO NPs. Also, proteinstructural changes and phospholipid molecular damage are more likely reasons for bacterialtoxicity. Toxicity of NPs is probably due to the dissolved metal ions and from NPs tendency to interact with the cell walls. Also, some very basic questions i.e. (i) the toxicities are due to nano- size or just because of composition? (ii) main mechanism of cell damage in NPs-cell surface" 1809 2371 W2403859484.pdf 6 7 separator 0.9943665 ¶ 2371 2373 W2403859484.pdf 6 8 caption 0.9960791 "Fig 3. (a) Kubelka-Munk function “F(R)2”plotted against wavelength (nm). Band gaps of ZnO NPs were also calculated." 2373 2491 W2403859484.pdf 6 9 separator 0.88199496 ¶ 2491 2493 W2403859484.pdf 6 10 caption 0.5154699 doi:10 2493 2500 W2403859484.pdf 6 11 paratext 0.52918965 . 2500 2501 W2403859484.pdf 6 12 caption 0.46021008 1371 2501 2505 W2403859484.pdf 6 13 paratext 0.48590085 / 2505 2506 W2403859484.pdf 6 14 caption 0.47806716 journal 2506 2513 W2403859484.pdf 6 15 paratext 0.5848049 .pone.0154704.g003 2513 2531 W2403859484.pdf 6 16 separator 0.98809254 ¶ 2531 2533 W2403859484.pdf 6 17 title 0.98497033 Antibacterial, Structural and Optical Properties of ZnO Nanoparticles 2533 2603 W2403859484.pdf 6 18 separator 0.7641426 ¶ 2603 2605 W2403859484.pdf 6 19 paratext 0.9775836 PLOS ONE | DOI:10.1371/journal.pone.0154704 May 16, 2016 7/1 2 2605 2668 W2403859484.pdf 6 0 paratext 0.9354757 81 0 2 W2614509524.pdf 24 1 separator 0.9916117 ¶ 2 4 W2614509524.pdf 24 2 bibliography 0.99341196 "Jiří DyndaTrkanjec 2013: Luka Trkanjec, “Chthonic aspects of the Pomeranian deity Triglav and other tricephalic characters in Slavic mythology” , in: Studia Mythologica Slavica 16 (2013), s. 9–25." 4 208 W2614509524.pdf 24 3 separator 0.99166584 ¶ 208 210 W2614509524.pdf 24 4 bibliography 0.99741966 "Turner 1969: Victor W . Turner, The Ritual Process: Structure and Anti-structure, Chicago: Aldine Publishing Company, 1969." 210 337 W2614509524.pdf 24 5 separator 0.98384154 ¶ 337 339 W2614509524.pdf 24 6 bibliography 0.9971448 "Versnel 1985: H. S. Versnel, “ Apollo and Mars One Hundred Y ears after Roscher” , in: Vis- ible Religion: Annual for Religious Iconography, Vol IV–V: Approaches to Iconology, Leiden: E. J. Brill, 1985–86, pp. 134–169." 339 564 W2614509524.pdf 24 7 separator 0.9828094 ¶ 564 566 W2614509524.pdf 24 8 bibliography 0.9967417 "Versnel 1990: H. S. Versnel, Ter Unus: Isis, Dionysos, Hermes – Three Studie in Henotheism (Inconsistencies in Greek and Roman Religion I), Leiden – New Y ork – København – Köln: E. J. Brill, 1990." 566 767 W2614509524.pdf 24 9 separator 0.9858981 ¶ 767 769 W2614509524.pdf 24 10 bibliography 0.9971539 "Watkins 1995: Calvert Watkins, How to Kill a Dragon: Aspect of Indo-European Poetics, New Y ork – Oxford: Oxford University Press, 1995." 769 909 W2614509524.pdf 24 11 separator 0.97853863 ¶ 909 911 W2614509524.pdf 24 12 bibliography 0.9975989 "West 2007: M. L. West, Indo-European Poetry and Myth, Oxford – New Y ork, Oxford Uni- versity Press, 2007." 911 1020 W2614509524.pdf 24 13 separator 0.98502076 ¶ 1020 1022 W2614509524.pdf 24 14 bibliography 0.9977678 "Witzel 2003: E. J. Michael Witzel, “Vedas and Upaniṣads” , in: Gavid Flood (ed.), The Black - well Companion to Hinduism , Malden: Blackwell, 2003, pp. 68–98." 1022 1183 W2614509524.pdf 24 15 separator 0.9842133 ¶ 1183 1185 W2614509524.pdf 24 16 bibliography 0.9974602 "Witzel 2012: E. J. Michael Witzel, The Origins of the World Mythologies, Oxford – New Y ork: Oxford University Press, 2012." 1185 1312 W2614509524.pdf 24 0 paratext 0.71195847 "Tropical Medicine and Infectious Disease" 0 43 W2947289793.pdf 0 1 separator 0.7233634 ¶ 43 45 W2947289793.pdf 0 2 title 0.76071644 Editorial 45 55 W2947289793.pdf 0 3 separator 0.7443819 ¶ 55 57 W2947289793.pdf 0 4 title 0.96853584 The One Health Approach—Why Is It So Important? 57 105 W2947289793.pdf 0 5 separator 0.9902208 ¶ 105 107 W2947289793.pdf 0 6 contact 0.9830858 "John S Mackenzie1,2,3,* and Martyn Jeggo4 1PathWest, Queen Elizabeth 2 Medical Centre, Nedlands, WA 6009, Australia 2Faculty of Health Sciences, Curtin University, GPO Box U1987, Perth, WA 6845, Australia 3One Health Platform Foundation, Overheet 48, 9290 Berlare, Belgium 4AUSGEM Governing Board, 31 The Breakwater, Corlette, NSW 2315, Australia; jeggo.martyn@gmail.com *Correspondence: j.mackenzie@curtin.edu.au; Tel.: +61-439875697" 107 554 W2947289793.pdf 0 7 separator 0.9251586 ¶ 554 556 W2947289793.pdf 0 8 paratext 0.97089875 "Received: 28 May 2019; Accepted: 30 May 2019; Published: 31 May 2019 /gid00030/gid00035/gid00032/gid00030/gid00038/gid00001/gid00033/gid00042/gid00045 /gid00001 /gid00048/gid00043/gid00031/gid00028/gid00047/gid00032/gid00046" 556 785 W2947289793.pdf 0 9 separator 0.993962 ¶ 785 787 W2947289793.pdf 0 10 text 0.9995819 "It has become increasingly clear over the past three decades that the majority of novel, emergent zoonotic infectious diseases originate in animals, especially wildlife [ 1], and that the principal drivers of their emergence are associated with human activities, including changes in ecosystems and land use, intensification of agriculture, urbanisation, and international travel and trade [ 2–6]. A collaborative and multi-disciplinary approach, cutting across boundaries of animal, human, and environmental health, is needed to understand the ecology of each emerging zoonotic disease in order to undertake a risk assessment, and to develop plans for response and control." 787 1473 W2947289793.pdf 0 11 separator 0.97955155 ¶ 1473 1475 W2947289793.pdf 0 12 text 0.9996315 "The term ‘One Health’ was first used in 2003–2004, and was associated with the emergence of severe acute respiratory disease (SARS) in early 2003 and subsequently by the spread of highly pathogenic avian influenza H5N1, and by the series of strategic goals known as the ‘Manhattan Principles’ derived at a meeting of the Wildlife Conservation Society in 2004, which clearly recognised the link between human and animal health and the threats that diseases pose to food supplies and economies. These principles were a vital step in recognising the critical importance of collaborative, cross-disciplinary approaches for responding to emerging and resurging diseases, and in particular, for the inclusion of wildlife health as an essential component of global disease prevention, surveillance, control, and mitigation [7]." 1475 2310 W2947289793.pdf 0 13 separator 0.983678 ¶ 2310 2312 W2947289793.pdf 0 14 text 0.99949306 "The outbreak of SARS, the first severe and readily transmissible novel disease to emerge in the 21st century, led to the realisation that (a) a previously unknown pathogen could emerge from a wildlife source at any time and in any place and, without warning, threaten the health, well-being, and economies of all societies; (b) there was a clear need for countries to have the capability and capacity to maintain an e ective alert and response system to detect and quickly react to outbreaks of international concern, and to share information about such outbreaks rapidly and transparently; and (c) responding to large multi-country outbreaks or pandemics requires global cooperation and global participation using the basic principles enshrined in One Health [ 8]. The emergence and spread of influenza H5N1 has been another excellent example of the importance of global cooperation and a One Health approach driven by the widespread concern that it might become the next influenza pandemic strain. It also served as a catalyst for the United Nations Secretary General to appoint a UN Systems Coordinator for Avian and Animal Influenza (UNSIC), and to form a major collaboration with a number of international and national organizations, including the World Health Organization (WHO), Food and Agriculture Organization (FAO), World Organization for Animal Health (OIE), United Nations Children’s Fund (UNICEF), and World Bank and various national heath ministries, to develop the International Ministerial Conferences on Avian and Pandemic Influenza (IMCAPI)." 2312 3899 W2947289793.pdf 0 15 separator 0.9720001 ¶ 3899 3901 W2947289793.pdf 0 16 text 0.99921 "IMCAPI was a major driver in the surveillance and responses to influenza H5N1 [ 9] and subsequently in the development of a strategic framework built around a One Health approach that focussed on diminishing the risk and minimizing the global impact of epidemics and pandemics due to emerging infectious diseases [10]." 3901 4225 W2947289793.pdf 0 17 separator 0.9848568 ¶ 4225 4227 W2947289793.pdf 0 18 paratext 0.9843359 Trop. Med. Infect. Dis. 2019 ,4, 88; doi:10.3390 /tropicalmed4020088 www.mdpi.com /journal /tropicalmed 4227 4331 W2947289793.pdf 0 0 table 0.9926701 "No-cyclops group (n = 51) Cyclopoid group (n = 27) Cyclops group (n = 16)105 patients TTT ≥ 4 group (n = 47) TTT < 4 group (n = 47) 120 patients" 0 147 W2895795204.pdf 2 1 separator 0.8516053 ¶ 147 149 W2895795204.pdf 2 2 table 0.9703911 "Matched Age, Sex, BMI, meniscus injuryExclusion  Previous ligament injury  Revision ACL reconstruction  Concomitant MCL injury (> grade III) 94 patients47 patients with TTT ≥ 4 58 patients with TTT < 4" 149 364 W2895795204.pdf 2 3 separator 0.98748565 ¶ 365 367 W2895795204.pdf 2 4 title 0.9049871 Subanalysis 367 379 W2895795204.pdf 2 5 separator 0.94261324 ¶ 379 381 W2895795204.pdf 2 6 table 0.4885807  381 383 W2895795204.pdf 2 7 text 0.67723495 Blood examination data at different time points between 3 groups: Table 383 455 W2895795204.pdf 2 8 table 0.53864515 3 455 457 W2895795204.pdf 2 9 separator 0.8025446 ¶ 457 459 W2895795204.pdf 2 10 table 0.5316194  459 461 W2895795204.pdf 2 11 text 0.4928922 Range of motion at different time points 461 502 W2895795204.pdf 2 12 table 0.47924918 502 503 W2895795204.pdf 2 13 text 0.590557 between 3 groups: Table 503 526 W2895795204.pdf 2 14 table 0.5562161 4 526 528 W2895795204.pdf 2 15 separator 0.99262416 ¶ 528 530 W2895795204.pdf 2 16 caption 0.9924484 "Fig. 1 Flow diagram of patients screened and grouped. ACL, anterior cruciate ligament; MCL, medial collateral ligament; BMI; body mass index; TTT, thymol turbidity test" 530 701 W2895795204.pdf 2 17 separator 0.8960941 ¶ 701 703 W2895795204.pdf 2 18 caption 0.99430287 "Fig. 2 Arthroscopic findings during second-look arthroscopy after ACL reconstruction. Knee flexion position ( a-c) and extension position ( d-f) are shown. A patient without cyclops ( a,d). A patient with a cyclopoid lesion ( b,e). A patient with a cyclops lesion impinging on the intercondylar notch ( c,f" 703 1014 W2895795204.pdf 2 19 paratext 0.96918833 )Kodama et al. BMC Musculoskeletal Disorders (2018) 19:367 Page 3 of 7 1014 1085 W2895795204.pdf 2 0 paratext 0.9900074 Nutrients 2023 ,15, 3823 6 of 17 0 32 W4386371524.pdf 5 1 separator 0.62218904 ¶ 32 34 W4386371524.pdf 5 2 paratext 0.9856625 Nutrients 2023 , 15, x FOR PEER REVIEW 6 of 17 34 82 W4386371524.pdf 5 3 separator 0.83307785 "¶ ¶" 83 94 W4386371524.pdf 5 4 caption 0.9599463 Figure 2. Maternal obesity aggravates CAWS -induced v asculitis in offspring mice . 94 178 W4386371524.pdf 5 5 text 0.9753366 "(A) OB group still weighed more than the WT group on a normal diet, while mice in both WT -CAWS group and OB-CAWS group showed a remarkabl e weight loss after the CAWS injection, and their body weight gradually recovered after 2 weeks of the experiment. The weight of mice in the WT -CAWS group returned to normal at the 4th week of the study, while the weight of mice in the OB -CAWS group recovered slowly and was still significantly lower than that of the control group at the end of the study. “**”, “***”, indicates p < 0.01, p < 0.001, respectively. (B) There was no significant difference in the heart weigh t/body weight ratio between different groups. ( C) H&E staining was used to ex- amine the histopathological changes of the aorta and abdominal aorta, and representative images are shown. The arrows indicate the main pathological changes." 178 1060 W4386371524.pdf 5 6 caption 0.9410519 "Scale bar of the abdominal aorta: 100 μm. Scale bar of the aorta: sca le bars of the upper pictures and the lower pictures are 200 μm and 50 μm, respectively." 1060 1225 W4386371524.pdf 5 7 separator 0.9966973 ¶ 1227 1229 W4386371524.pdf 5 8 title 0.99352926 3.2. Maternal Obesity Induces Altered Cardiac Structure in Offspring Mice 1229 1303 W4386371524.pdf 5 9 separator 0.99514073 ¶ 1305 1307 W4386371524.pdf 5 10 text 0.99920404 "To determine whether maternal obesity affected the cardiac conformation of off- spring mice, ec hocardiography was used to monitor the relevant parameters. In the pre- sent study, maternal obesity demonstrated several structural alternations in the left ven- tricular (LV) of the offspring. In detail, maternal obesity is associated with thicker left ven- tricular posterior wall in end -systole (LVPWs) and end -diastole (LVPWd) (Figure 3A, B), thicker interventricular septum in end -systole (IVSs) (Figure 3C) and end -diastole (IVSd) (Figure 3D), decreased left ventricular internal dimension in end -systole (LVIDs ) (Figure" 1307 1951 W4386371524.pdf 5 11 separator 0.98552483 ¶ 1952 1954 W4386371524.pdf 5 12 caption 0.96236545 Figure 2. Maternal obesity aggravates CAWS-induced vasculitis in offspring mice. ( A) OB 1954 2043 W4386371524.pdf 5 13 text 0.97657216 "group still weighed more than the WT group on a normal diet, while mice in both WT-CAWS group and OB-CAWS group showed a remarkable weight loss after the CAWS injection, and their body weight gradually recovered after 2 weeks of the experiment. The weight of mice in the WT-CAWS group returned to normal at the 4th week of the study, while the weight of mice in the OB-CAWS group recovered slowly and was still significantly lower than that of the control group at the end of the study. “**”, “***”, indicates p< 0.01, p< 0.001, respectively. ( B) There was no significant difference in the heart weight/body weight ratio between different groups. ( C) H&E staining was used to examine the histopathological changes of the aorta and abdominal aorta, and representative images are shown. The arrows indicate the main pathological changes." 2043 2897 W4386371524.pdf 5 14 caption 0.7193637 "Scale bar of the abdominal aorta: 100m.Scale bar of the aorta: scale bars of the upper pictures and the lower pictures are 200 m and 50m, respectively." 2897 3056 W4386371524.pdf 5 0 paratext 0.7149477 15Y east from Di 0 16 W2946383414.pdf 15 1 title 0.52934974 stillery 16 24 W2946383414.pdf 15 2 paratext 0.8878802 "Plants: A New Approach DOI: http://dx.doi.org/10.5772/intechopen.86291" 24 97 W2946383414.pdf 15 3 separator 0.9920432 ¶ 97 99 W2946383414.pdf 15 4 table 0.9957373 "Y east species Pb (II) Cd (II) Cr (VI) Time (h) 0.2 3 6 24 48 0.2 3 6 24 48 0.2 3 6 24 48 C. ethanolica 2.0 1.2 2.2 2.9 4.0 2.6 0.9 2.7 1.8 2.9 - - - 0.6 0.2 C. lactis-condensi 10.9 10.6 10.6 9.6 9.8 0.7 0.4 1.5 -0.2 5.0 - - - - - C. sake 4.7 10.1 8.0 10.5 10.2 2.4 2.4 0.9 2.3 -0.1 - - - - - H. meyeri 16.8 20.7 20.5 21.4 14.2 - - - - - - 0.6 1.2 0.5 0.9 H. osmophila 5.6 6.6 7.4 5.0 5.8 6.4 4.9 5.4 6.1 5.3 - - - 0.9 - H. uvarum 5.3 5.8 9.4 9.6 10.4 3.9 6.8 6.4 8.2 8.7 4.6 4.8 6.3 4.9 1.4 H. valbyensis 3.8 9.2 5.7 6.4 5.0 0.3 0.6 0.9 - - 3.3 3.4 2.5 3.8 1.3 H. vineae 9.9 9.8 9.5 8.6 9.4 5.2 5.6 7.4 5.8 4.5 1.9 2.6 2.4 3.0 3.3 L. thermotolerans 1.3 1.3 2.3 0.4 18.2 2.7 4.0 3.1 1.6 1.9 - 2.3 1.4 2.2 3.7 O. polymorpha 10.8 10.0 9.9 11.1 10.5 4.5 4.3 5.0 4.4 4.2 - - - - - P . anomala 5.1 5.7 9.6 10.3 10.7 5.1 4.9 5.1 6.0 5.8 - 2.2 2.7 3.4 3.4 P . galeiformis 0.9 3.0 2.3 2.0 1.7 3.3 6.8 6.7 7.1 7. 0 - - - - 1.8 P . kudriavzevii 18.5 19.6 21.5 19.2 19.3 10.5 11.3 11.2 12.3 12.8 7.1 7.4 2.1 0.8 0.2 P . membranaefaciens 20.7 20.4 20.9 20.1 20.2 2.8 3.2 3.3 2.6 2.3 9.5 9.7 11. 8.9 8.2 S. cerevisiae 6.0 6.6 9.0 8.1 10.7 5.2 6.1 6.1 6.1 7.6 2.0 3.8 5.7 4.4 4.8 S. ludwigii 19.7 22.7 28.1 2 7.8 30.1 1.0 2.6 3.3 2.3 0.2 4.1 5.6 4.5 7.5 5.7 T . delbrueckii 3.2 4.2 5.0 7.7 8.6 2.2 2.2 3.3 3.1 3.4 0.9 3.5 3.8 5.3 4.2 Z. bailii 19.4 19.1 19.5 13.5 17. 0 0.4 0.8 0.5 2.0 2.8 - 0.2 - 1.1 1.2 Z. fermentati 6.9 7.8 9.9 7.9 7.6 7.6 8.2 10.4 11.4 13.7 3.5 3.2 3.1 2.4 3.3" 99 1610 W2946383414.pdf 15 5 separator 0.9567611 ¶ 1610 1612 W2946383414.pdf 15 6 title 0.88341606 Table 4. 1612 1621 W2946383414.pdf 15 7 separator 0.9875357 ¶ 1623 1625 W2946383414.pdf 15 8 title 0.46595865 Percentage 1625 1636 W2946383414.pdf 15 9 table 0.4806399 elimin 1636 1643 W2946383414.pdf 15 10 title 0.43579122 ation 1643 1648 W2946383414.pdf 15 11 table 0.54310834 of Pb (II), Cd (II) and Cr (VI) by different yeast species compared to the contr ol 1648 1732 W2946383414.pdf 15 0 paratext 0.99041677 Agronomy 2020 ,10, 320 10 of 15 0 31 W3008585290.pdf 9 1 separator 0.9960438 ¶ 31 33 W3008585290.pdf 9 2 title 0.9938033 3.2.3. Proportion of Soil Respiration to Ecosystem Respiration 33 96 W3008585290.pdf 9 3 separator 0.99681735 ¶ 96 98 W3008585290.pdf 9 4 text 0.9982685 Overall, averaged SR represented about 31% of ER on the upland (13.4 out of 43.2 kg CO 2-C ha 98 192 W3008585290.pdf 9 0 text 0.9996184 "targeted technology studies that sample surrogate users , 69.7% use students, and 23.6% use crowdworkers, with the remaining employing faculty/staff, or not even mentioning the make-up of the sample. These user types are considered as surrogates for real users when they are not from the target population of the technology developed, and the impact of the high use of surrogate users for targeted technologies is an exciting area for future research." 0 459 W4307164453.pdf 18 1 separator 0.98674035 ¶ 459 461 W4307164453.pdf 18 2 text 0.9996744 "At some level, the use of surrogate users is understandable for many researchers, as the availability of real users can be limited, recruitment of real users in suf ficient numbers can be quite challenging, and the payment of real users in substantial numbers can be somewhat expensive. However, there are methods to address or at least mitigate these hurdles. Based primarily on the experience of the authors, some of these techniques are:" 461 909 W4307164453.pdf 18 3 separator 0.95821935 ¶ 909 911 W4307164453.pdf 18 4 text 0.88769543 /C15Crowd 911 921 W4307164453.pdf 18 5 title 0.7610921 worker 921 927 W4307164453.pdf 18 6 text 0.99692106 "Platforms : Unlike MTurk, which at the time of this study provides limited sample selection features, some other crowdworker platforms offer rather sophisticated sampling methods and access to populations of real users from various domains, demographics, and experiences, mitigating access issues to real users and offering the payment of real users at a reasonable cost. Additionally, some of these platforms offer advance quality control features, although, of course, there are both pros and cons of using these crowdworker platforms ( Peer et al., 2022 ;Salminen, Jung & Jansen, 2021 )." 927 1532 W4307164453.pdf 18 7 separator 0.99563915 ¶ 1532 1534 W4307164453.pdf 18 8 title 0.9716096 "/C15Partnering with Commercial Companies, Non-pro fits, and Governmental Organizations" 1534 1622 W4307164453.pdf 18 9 text 0.99946153 ": Paying real users , especially in some specialty domains, can be rather expensive. A technique to help mitigate the cost of real users for user studies is to partner with a commercial entity (or non-pro fit or government agency) to provide participants and conduct the user study at the workplace to minimize disruptions to the employees ’ work schedules. The authors find the offering of a ‘thank you ’such as a gift card to be a nice touch. Others have also called for closer collaborations by academia with these other forms of organizations ( Lutchen, 2018 ;Mullin, 2021 ;Turin et al., 2022 )." 1622 2232 W4307164453.pdf 18 10 separator 0.99436176 ¶ 2232 2234 W4307164453.pdf 18 11 text 0.85969704 /C15 2234 2239 W4307164453.pdf 18 12 title 0.9093568 Mix of Real and Surrogate Users 2239 2270 W4307164453.pdf 18 13 text 0.99921584 ": Some studies may require a substantial number of real users that may be unrealistic to recruit or pose a prohibitive expense. A workaround can be a mix of real users andsurrogate users ; basically, running two user studies –one with a smaller sample of real users and one with a larger sample of surrogate users , comparing the results between the two samples. For example, say you need 200 participants to achieve some effect size, and recruiting this number of real users is unrealistic, given the availability of real users or cost. One technique could be to run user study one with 200 surrogate users that are easier to recruit or less expensive. Then, conduct user study two with, say, 30 real users (a much more manageable number) as an external validity check. However, this approach does come with the additional cost of executing more than one user study." 2270 3158 W4307164453.pdf 18 14 separator 0.981078 ¶ 3158 3160 W4307164453.pdf 18 15 text 0.9996777 "The practicalities of the research process ( i.e., the constraints in which researchers design their studies and sampling strategies) further complicate the picture. Namely, one can argue that lab-based experiments sacri fice external validity and realism for internal validity and control (see Fig. 3 ). Such experiments often use convenience samples," 3160 3518 W4307164453.pdf 18 16 separator 0.9804484 ¶ 3518 3520 W4307164453.pdf 18 17 paratext 0.8490327 Salminen et al. (2022), PeerJ Comput. Sci. , DOI 10.7717/peerj-cs.1136 19/30 3520 3597 W4307164453.pdf 18 0 paratext 0.94525874 7 0 1 W3166619682.pdf 6 1 separator 0.94227093 ¶ 1 3 W3166619682.pdf 6 2 title 0.9928845 Economic impact of Huanglongbing on orange production 3 57 W3166619682.pdf 6 3 separator 0.9948303 ¶ 57 59 W3166619682.pdf 6 4 text 0.99952006 "In the second scenario, the plant production capacity was considered throughout its useful life (Table 4). In this situation, the impact of eradicating a 1-year-old a plant extends to the third year of production. Unlike in the first scenario, plants under three years of age generate losses related to the deployment cost and production capacity alone, because these plants start producing fruits only in the fourth year. In this scenario, it was more evident that the losses were related to plants between 5 and 11 years of age, and not older, and the cost generated by HLB in orange production was estimated to be almost US$15.7 million per year." 59 739 W3166619682.pdf 6 5 separator 0.996717 ¶ 739 741 W3166619682.pdf 6 6 title 0.73744905 "Table 4. Economic impact of losses caused by Huanglongbing (HLB) based on plant age, considering the orange plant production capacity throughout its useful life (scenario 2), in Paranavaí micro-region, state of Paraná, in the period from January 2011 to June 2013." 741 1013 W3166619682.pdf 6 7 separator 0.986323 ¶ 1013 1015 W3166619682.pdf 6 8 table 0.99668187 "Plant ageYearTotal2011 2012 2013 Years Losses US$ (1) 1 576.08 0.00 14,833.35 31,078.80 2 3,706.23 33,108.83 36,197.35 214,649.81 3 46,908.73 63,504.63 60,710.40 434,384.17 4 53,511.84 54,075.29 36,719.63 738,184.56 5 82,183.22 186,057.03 518,906.54 3,202,873.13 6 80,556.27 63,219.21 854,606.97 4,186,399.14 7 378,143.69 55,958.22 815,418.39 4,078,359.82 8 217,738.63 368,239.07 503,709.85 3,562,869.07 9 257,701.75 225,843.00 1,199,423.95 5,656,052.99 10 105,662.82 182,865.82 1,099,742.99 4,514,866.25 11 81,344.26 74,571.95 689,976.76 2,486,541.77 12 12,689.35 11,537.24 225,579.63 737,859.54 13 21,361.32 6,277.78 121,965.65 439,390.30 14 19,317.45 22,793.56 62,609.11 297,305.59 15 16,468.26 7,541.96 63,299.85 250,742.82 16 9,992.06 14,897.73 10,415.02 104,661.06 17 11,235.69 1,788.58 66,038.82 234,348.84 18 31,621.45 108,884.60 43,922.34 547,696.49 19 16,283.72 8,191.58 435,154.99 1,373,251.22 20 38,643.03 28,160.95 23,849.76 271,961.32 20+ (2)337,878.81 61,793.97 931,528.14 3,993,602.75 WI (3)234,851.45 0.00 380,302.92 1,845,463.20 Total 6,770,428.10 5,292,492.64 27,139,621.91 39,202,542.65" 1015 2172 W3166619682.pdf 6 9 separator 0.9887172 ¶ 2172 2174 W3166619682.pdf 6 10 table 0.6254316 Notes 2174 2180 W3166619682.pdf 6 11 text 0.51455283 : (1) Real values of December 2019. (2) Refers to plants over 20 years of age, 2180 2258 W3166619682.pdf 6 12 table 0.44985446 and 2258 2262 W3166619682.pdf 6 13 text 0.5179929 is considered the p 2262 2282 W3166619682.pdf 6 14 table 0.48511848 roductivity of a 20-year 2282 2306 W3166619682.pdf 6 15 text 0.49849963 -old 2306 2310 W3166619682.pdf 6 16 table 0.4508372 plant 2310 2316 W3166619682.pdf 6 17 text 0.6505474 ". (3) Refers to plants without age identification, and is considered the average productivity ." 2316 2414 W3166619682.pdf 6 18 separator 0.9823216 ¶ 2414 2416 W3166619682.pdf 6 19 text 0.99955994 "It is notable that, despite the cost of an inspection being lower than the cost of applying insecticides for psyllid control, most producers perform management for vector control, and regardless of the validity of normative instruction No. 53, of October 16, 2008, of MAPA, some producers do not eradicate infected plants (BELASQUE JUNIOR et al., 2010b; 2010c). Furthermore, the eradication of all symptomatic plants will not necessarily result in the eradication of all infected plants, because asymptomatic plants can exist (GOTTWALD, 2010). In addition, there is a direct and immediate loss when a symptomatic but productive plant is eradicated, especially adult plants with initial disease symptoms, that is, plants that would be productive for some more years (BASSANEZI et al., 2013b).The eradication of diseased plants is a strategy used when the HLB incidence is low; however, it becomes unfeasible when there are many infected plants, as in the case of Florida, USA (FARNSWORTH et al., 2014; TANSEY et al., 2017). In both Florida and Brazil, other measures, such as increasing the planting density, have been used; they contributed significantly to an increase in income per unit area (TREJO-PECH et al., 2018). In addition, the American industry tried to adopt other approaches for damage mitigation, based on the assumption that it would be possible to produce under disease conditions, through insecticide applications for psyllid control and implementation of a nutritional program with the use of leaf macro and micronutrients," 2416 4039 W3166619682.pdf 6 20 separator 0.85479355 ¶ 4040 4042 W3166619682.pdf 6 21 bibliography 0.83376086 Rev. Bras. Frutic., Jaboticabal, 2021, v. 43, n. 3 (e-472) 4042 4102 W3166619682.pdf 6 0 paratext 0.97756904 JHEP10(2021)181 0 15 W3210007855.pdf 5 1 text 0.9663864 "We consider four different structures in the quark sector, Q1-Q4, which are defined by the choice of (A1...4)(A5...8):" 15 133 W3210007855.pdf 5 2 separator 0.9856687 ¶ 133 135 W3210007855.pdf 5 3 math 0.5996442 "Q1 : (2222)(1212) , y u∼ H2H2 H2H2 , y d∼ H2H1 H2H1 , Q2 : (1122)(2211) ," 135 231 W3210007855.pdf 5 4 table 0.47028923 231 232 W3210007855.pdf 5 5 math 0.4797536 y 232 233 W3210007855.pdf 5 6 table 0.48037603 u∼ 233 236 W3210007855.pdf 5 7 math 0.72595537 " H2H2 H1H1 , y d∼ H1H1 H2H2 , Q3 : (1212)(2121) , y u∼ H2H1 H2H1 , y d∼ H1H2 H1H2 , Q4 : (2121)(1111) , y u∼ H1H2 H1H2 , y d∼ H1H1 H1H1 , (2.9)" 236 443 W3210007855.pdf 5 8 separator 0.8415338 ¶ 443 445 W3210007855.pdf 5 9 text 0.973985 "where we also indicate in 2+1 flavor space notation to which Higgs field the quark bilinears couple to. Together with the last term in eq. ( 2.7) this choice fixes the PQ color anomaly coefficientN, the quark contribution to the electromagnetic anomaly coefficient EQ, and all couplings of the QCD axion to quarks CA,V qiqjin terms of the parameters tanβandξqP ij (to be defined below), which we summarize in table 1." 445 867 W3210007855.pdf 5 10 separator 0.949247 ¶ 867 869 W3210007855.pdf 5 11 text 0.97942394 "The quark Yukawa Lagrangians of each model is combined with one out of the four following structures in the charged lepton sector, defined by (A9...12), i.e. the Higgs to which a lepton bilinear couples in 2 + 1flavor space" 869 1095 W3210007855.pdf 5 12 separator 0.98326445 ¶ 1095 1097 W3210007855.pdf 5 13 math 0.87558144 "E1L : (1122) , y e∼ H2H2 H1H1 , E1R : (1212) , y e∼ H2H1 H2H1 , E2L : (2211) , y e∼ H1H1 H2H2 , E2R : (2121) , y e∼ H1H2 H1H2 . (2.10)" 1097 1278 W3210007855.pdf 5 14 separator 0.96708155 ¶ 1278 1280 W3210007855.pdf 5 15 text 0.9728268 "This choice fixes the charged lepton contribution to the electromagnetic anomaly coefficient ELand the axion couplings to leptons CV,A /lscripti/lscriptj, which we summarize in table 2." 1280 1467 W3210007855.pdf 5 16 separator 0.83444494 ¶ 1467 1469 W3210007855.pdf 5 17 text 0.9962629 "Since each quark sector model can be combined with any charged lepton sector model, we have in total 16 different models, which we denote by e.g. “Q1E1L”, which has the Higgs structure (2222)(1212)(1122), axion couplings to quarks and charged leptons as in tables 1 and 2, and an electromagnetic anomaly coefficient E/Nthat is the sum of both sectors,E/N =EQ/N+EL/N= 8/3in this example." 1469 1861 W3210007855.pdf 5 18 separator 0.98158514 ¶ 1861 1863 W3210007855.pdf 5 19 text 0.90958524 "The couplings to quarks and leptons depend on the Higgs vacuum angle tanβand the parameters ξfP ij, withf=u,d,eandP=L,R, which are defined by ¶" 1863 2010 W3210007855.pdf 5 20 math 0.83792585 "tanβ≡/angbracketleftH2/angbracketright//angbracketleftH1/angbracketright, ξfP ij≡(VfP)∗ 3i(VfP)3j, (2.11)" 2010 2120 W3210007855.pdf 5 21 separator 0.88703763 ¶ 2120 2122 W3210007855.pdf 5 22 math 0.86331517 – 5 – 2122 2128 W3210007855.pdf 5 0 paratext 0.9686764 "The Classical Review http://journals.cambridge.org/CAR" 0 56 W2034202432.pdf 0 1 separator 0.9920288 ¶ 56 58 W2034202432.pdf 0 2 title 0.7699087 Additional services for The Classical Review: 58 104 W2034202432.pdf 0 3 separator 0.93776053 ¶ 104 106 W2034202432.pdf 0 4 text 0.66663617 Email alerts: Click here 106 131 W2034202432.pdf 0 5 table 0.4121032 ¶ 132 135 W2034202432.pdf 0 6 text 0.5367668 Subscriptions: Click here 135 160 W2034202432.pdf 0 7 table 0.5431499 ¶ 161 163 W2034202432.pdf 0 8 text 0.5123267 Commercial reprints: Click here 163 195 W2034202432.pdf 0 9 separator 0.41935697 196 197 W2034202432.pdf 0 10 table 0.4761144 ¶ 197 199 W2034202432.pdf 0 11 text 0.5730968 Terms of use : Click here 199 224 W2034202432.pdf 0 12 separator 0.9939556 ¶ 224 226 W2034202432.pdf 0 13 paratext 0.6465196 Propertius IV. 1. 27 226 247 W2034202432.pdf 0 14 separator 0.8640288 ¶ 248 250 W2034202432.pdf 0 15 paratext 0.93308944 H. E. Butler 250 263 W2034202432.pdf 0 16 separator 0.72999835 ¶ 264 266 W2034202432.pdf 0 17 paratext 0.96250916 The Classical Review / Volume 22 / Issue 08 / December 1908, pp 245 - 245 266 340 W2034202432.pdf 0 18 separator 0.65510356 ¶ 341 343 W2034202432.pdf 0 19 paratext 0.97908896 DOI: 10.1017/S0009840X00002249, Published online: 27 October 2009 343 409 W2034202432.pdf 0 20 separator 0.5774024 ¶ 410 412 W2034202432.pdf 0 21 paratext 0.9788998 Link to this article: http://journals.cambridge.org/abstract_S0009840X00002249 412 491 W2034202432.pdf 0 22 separator 0.9283544 ¶ 491 493 W2034202432.pdf 0 23 paratext 0.95739955 How to cite this article: 493 519 W2034202432.pdf 0 24 separator 0.63694113 519 520 W2034202432.pdf 0 25 paratext 0.9240525 "¶ H. E. Butler (1908). Propertius IV. 1. 27. The Classical Review, 22, pp 245-245 doi:10.1017/ S0009840X00002249" 520 634 W2034202432.pdf 0 26 separator 0.49563062 635 636 W2034202432.pdf 0 27 paratext 0.93533474 "¶ Request Permissions : Click here Downloaded from http://journals.cambridge.org/CAR, IP address: 130.133.8.114 on 02 May 2015" 636 764 W2034202432.pdf 0 28 separator 0.99501455 ¶ 764 766 W2034202432.pdf 0 0 paratext 0.9900076 Sustainability 2020 ,12, 7174 4 of 19 0 37 W3082203972.pdf 3 1 separator 0.99520653 ¶ 37 39 W3082203972.pdf 3 2 text 0.99960274 "Our study extends the existing literature in three ways. First, our study considers a system including a government implementing the take-back policy of penalty or subsidy and a manufacturer responsible for collecting their used products. Second, from the government’s standpoint, we further characterize the optimal penalty or subsidy and analyze the e ectiveness and e ciency of the take-back policy. Third, we simultaneously identify the decision of eco-design or remanufacturing for a manufacturer, based on which we provide a set of guidelines in practical managerial recommendations for governments and manufacturers. In the current literature, there has not been research on the subject of the e ect of regulation policy of take-back penalty or subsidy on a manufacturer’s production strategy choice of eco-design and remanufacturing has not been studied to date." 39 929 W3082203972.pdf 3 3 separator 0.9967514 ¶ 929 931 W3082203972.pdf 3 4 title 0.9906426 3. Model Development 931 952 W3082203972.pdf 3 5 separator 0.99702966 ¶ 952 954 W3082203972.pdf 3 6 text 0.99937403 "Consider a single government and a single manufacturer as two decision-makers deciding for themselves variables to maximize social welfare and profit. The manufacturer produces a brand new product and collects properly end-of-use products to reduce pollution by o ering financial incentives to original consumers, in the first step. On the other side, the government expects the manufacturer to recycle, and applies the regulation policy, i.e., the take-back penalty or subsidy." 954 1439 W3082203972.pdf 3 7 separator 0.68564785 ¶ 1439 1441 W3082203972.pdf 3 8 text 0.9991517 "Specifically, the government limits the manufacturer’s collection behavior by imposing the take-back penalty and supports this behavior using the take-back subsidy, considering the impact of landfill pollution products on the environment from the social welfare side. Finally, under the di erent policies, the manufacturer reacts respectively by remanufacturing or performing eco-design. Therefore, we discuss four scenarios, based on Stackelberg game structures. The notations used in our models are presented in Table 1." 1441 1973 W3082203972.pdf 3 9 separator 0.99707115 ¶ 1973 1975 W3082203972.pdf 3 10 title 0.97422916 Table 1. Summary of basic notations. 1975 2012 W3082203972.pdf 3 11 separator 0.9889002 ¶ 2012 2014 W3082203972.pdf 3 12 title 0.6801419 Parameters 2014 2025 W3082203972.pdf 3 13 separator 0.5603979 2025 2026 W3082203972.pdf 3 14 table 0.97504354 "¶ cN cost of manufacturing from virgin materials cR cost of remanufacturing acquisition e ciency D per unit recycle processing cost eco-design cost coe cient processing cost reduction e ectiveness of eco-design per unit of products monetary value of environmental impact of landfill, associated with amount of toxic materials initial customer valuation of the remanufactured products" 2026 2435 W3082203972.pdf 3 15 separator 0.9519032 ¶ 2435 2437 W3082203972.pdf 3 16 title 0.70062673 Decision Variables 2437 2456 W3082203972.pdf 3 17 separator 0.5211641 2456 2457 W3082203972.pdf 3 18 table 0.9759975 "¶ qN quantity of brand-new products qR quantity of remanufactured products qA quantity of collected products e reduction amount of toxic materials in product (emission reduction) k per unit take-back penalty s per unit take-back subsidy" 2457 2703 W3082203972.pdf 3 19 separator 0.8414209 ¶ 2703 2705 W3082203972.pdf 3 20 title 0.50494903 Dependent 2705 2716 W3082203972.pdf 3 21 table 0.87510836 "Variables pN new product’s price pR remanufactured product’s price Mi the manufacturer’s profit in scenario iwhere i2f1, 2, 3, 4g Gi the government’s social welfare in scenario iwhere i2f1, 2, 3, 4g" 2716 2923 W3082203972.pdf 3 22 separator 0.9774158 ¶ 2923 2925 W3082203972.pdf 3 23 text 0.9935063 Meanwhile, we discuss some assumptions which are considered in this paper as follows. 2925 3011 W3082203972.pdf 3 24 separator 0.97881967 ¶ 3011 3013 W3082203972.pdf 3 25 text 0.9849018 Demand functions: For consumers, their valuation from consuming new products is UN=v 3013 3098 W3082203972.pdf 3 0 separator 0.9844208 ¶ ¶ 1 8 W3005124297.pdf 1 1 caption 0.99622285 Figure 1. time series of JIXN(left) and HRBN(right) station. 8 70 W3005124297.pdf 1 2 separator 0.94890773 "¶ ¶ ¶" 71 85 W3005124297.pdf 1 3 title 0.9944263 2.1 Periodic model of GNSS reference station 85 130 W3005124297.pdf 1 4 separator 0.9925053 ¶ 131 133 W3005124297.pdf 1 5 text 0.99962866 "We use the spectral analysis method to study the time series, aimed to detected whether the time series contain some other periodic signals, it can also verify the geophysical models have already been deducted in data process or not. The results of spectral analysis show that the most significant signal in the time series of horizontal direction is the annual period (see Figure 2, Figure 3), the semi-annual period followed." 133 579 W3005124297.pdf 1 6 separator 0.97983956 ¶ ¶ 580 586 W3005124297.pdf 1 7 caption 0.9937742 "Figure 2. Spectral analysis results of the north and south direction. (Red circle means the main period is annual, blue circle shows the main period is semi-annual, and green circle represents the main period is other term)" 586 819 W3005124297.pdf 1 8 separator 0.99170566 ¶ ¶ 820 826 W3005124297.pdf 1 9 title 0.9940048 2.2 Velocity model of GNSS reference station 826 871 W3005124297.pdf 1 10 separator 0.99420464 ¶ 873 875 W3005124297.pdf 1 11 text 0.9996014 "Based on the above model, we get the velocity field of Chinese mainland (see Fig 4), the average possible error of horizontal velocity is ±0.3mm,vertical direction is about ±0.5mm." 875 1063 W3005124297.pdf 1 12 separator 0.8283434 "¶ ¶" 1064 1074 W3005124297.pdf 1 13 caption 0.9961336 "Figure 3. Spectral analysis results of the east and west direction. (the same as Fig 2)" 1074 1165 W3005124297.pdf 1 14 separator 0.85310864 "¶ ¶ ¶" 1166 1180 W3005124297.pdf 1 15 caption 0.9946731 "Figure 4. Velocity field of Chinese mainland (relative to ITRF2014)" 1180 1251 W3005124297.pdf 1 16 separator 0.9889926 ¶ ¶ 1252 1258 W3005124297.pdf 1 17 title 0.9939308 3. METHOD FOR REFERENCE TRANSFORMATION 1258 1297 W3005124297.pdf 1 18 separator 0.9954002 ¶ 1298 1300 W3005124297.pdf 1 19 text 0.9994933 "Tight constraint method and S-transformation method are the two widely used methods for frame transformation." 1300 1413 W3005124297.pdf 1 20 separator 0.9607502 ¶ ¶ 1415 1421 W3005124297.pdf 1 21 title 0.9720644 3.1 Tight constraint method : 1421 1451 W3005124297.pdf 1 22 separator 0.98691404 ¶ 1452 1454 W3005124297.pdf 1 23 text 0.9997069 "A wide range of papers has been published on the concept of the free network and optimal methods of computing a set of coordinates from a singular normal equation. The set of constraints usually added to a free-network normal equation by tight constrained method (Mittermyer 1972; Perelmuter 1979; Blaha 1982;Dermanis 1994a;Xu 1997). The tight constraint is used in the situation that absence of datum, some stable stations are generally selected as the core station, and the value of the coordinate and velocity under a certain reference frame is taken as true value. It need high accuracy of the core stations’ coordinates. Constrained least squares estimates can be implemented with Lagrangian multipliers. Although it is very effective to solve the rank-deficient problem of the normal equation, however it will cause the geodetic control network be deformed, means will generate bias for the coordinate of the stations that located far away from the core station." 1454 2468 W3005124297.pdf 1 24 separator 0.94935817 ¶ ¶ 2469 2475 W3005124297.pdf 1 25 paratext 0.96054214 The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, Volume XLII-3/W10, 2020 2475 2598 W3005124297.pdf 1 26 separator 0.667081 ¶ 2599 2601 W3005124297.pdf 1 27 paratext 0.9518499 "International Conference on Geomatics in the Big Data Era (ICGBD), 15–17 November 2019, Guilin, Guangxi, China This contribution has been peer-reviewed. https://doi.org/10.5194/isprs-archives-XLII-3-W10-535-2020 | © Authors 2020. CC BY 4.0 License. ¶ 536" 2601 2865 W3005124297.pdf 1 0 paratext 0.97447914 "fnut-09-1048305 November 25, 2022 Time: 15:36 # 10 Teuma et al. 10.3389/fnut.2022.1048305" 0 91 W4311047860.pdf 9 1 separator 0.99263865 ¶ 91 93 W4311047860.pdf 9 2 caption 0.9462013 FIGURE 6 93 102 W4311047860.pdf 9 3 separator 0.66081667 ¶ 102 104 W4311047860.pdf 9 4 caption 0.9912656 "Glucosamine decreases the number of a-SMA+ endothelial cells in diabetic nephropathy. (A)Representative images are shown from double immunofluorescence staining with a-SMA and marker for endothelial cells CD31. (B)Quantification of a-SMA+ endothelial cells normalized to the glomerular areas (20 glomeruli analyzed per kidney). The experiments were repeated in 3 kidneys each group. Arrows indicate the illustrative co-localization of a-SMA and CD31. Data are shown in meanSEM. n= 20. *** p<0.001." 104 617 W4311047860.pdf 9 5 separator 0.990308 ¶ 617 619 W4311047860.pdf 9 6 text 0.99964666 "The effect of glucosamine on mesangial expansion in the diabetic nephropathy has not been reported. Glucosamine was proposed to be deteriorative in diabetic nephropathy based on the hypothesis that endogenous glucosamine promotes the activation of the HBP , which is linked to the development of DN." 619 926 W4311047860.pdf 9 7 separator 0.75143266 ¶ 926 928 W4311047860.pdf 9 8 text 0.99974847 "Nevertheless, glucosamine was found to possess an antifibrotic effect in the mouse model of unilateral ureteral obstruction with progressive renal fibrosis. Park et al., demonstrated that the fibrosis displayed by Masson trichrome staining was reduced with a concomitant inhibition of a-SMA expression upon glucosamine treatment (18). Furthermore, an inhibition of other gene expression related to fibrosis except a-SMA, such as fibronectin and collagen, was also shown in that paper.However, in our study, we detected a reduction of fibronectin protein expression in glomeruli, but no effect of glucosamine on the mRNA expression of FN-1, a-SMA, Col 1A1, 3A1, 4A1, 4A3, and CTGF could be determined. An interesting finding in present study is the inhibitory effect of glucosamine ona-SMA expression in control kidneys as well. Differential regulation of fibronectin and collagen 4 by glucosamine may be a result of different molecular characters and the early stage of fibrosis in the glomeruli in the study. Additionally, glucosamine might inhibit the initiation of accumulation of extracellular matrix in diabetic nephropathy as a consequence of maintaining expression of a-SMA at a lower level." 928 2149 W4311047860.pdf 9 9 separator 0.9761516 ¶ 2149 2151 W4311047860.pdf 9 10 text 0.99973726 "In the current study, glucosamine showed an inhibitory impact on mesangial expansion and expression of fibronectin anda-SMA. Nevertheless, glucosamine is likely not eliminating all ECM components, such as collagen 1, 3 and 4. Several studies showed that expression of extracellular matrix proteins such asa-SMA is controlled by the expression or activity of TGF- b, a key growth factor involved in renal fibrosis. Nevertheless, the data reported on the impact of glucosamine on TGF- b expression or activity are controversial. Park et al., reported an inhibitory effect of glucosamine on the expression of TGF- b expression, while, on the contrary, Kolm-Litty et al., showed that glucosamine increased RNA expression and activity of TGF- bin mesangial cells (5, 18). It seems that cell types, culture conditions, and glucosamine dosage can explain the variation in experimental results. Additionally, in our study, increased expression of CTGF, fibronectin, and collagen 4 was detected in the diabetic kidneys. However, glucosamine affected the expression of fibronectin, but not other extracellular matrix proteins in either non-diabetic or diabetic conditions. It denotes that there might be other possible mechanisms through which glucosamine hampers the accumulation of extracellular matrix in the kidney." 2151 3497 W4311047860.pdf 9 11 separator 0.97472113 ¶ 3497 3499 W4311047860.pdf 9 12 text 0.99973196 "Another interesting finding in the study is that glucosamine lowered not only the expression of a-SMA in diabetic kidneys, but also the number of a-SMA+ endothelial cells. a-SMA is expressed by renal tubular cells, mesangial cells, and endothelial cells. a-SMA has been identified as a marker of myofibroblasts, implicated in Endothelial- and Epithelial-MT in DN. Podocytes in glomeruli may undergo EMT in DN as well. However, we did not detect obvious a-SMA+ podocytes in our study." 3499 3994 W4311047860.pdf 9 13 separator 0.978397 ¶ 3994 3996 W4311047860.pdf 9 14 text 0.98413897 "The role of podocytes in glucosamine-induced improvement of extracellular matrix accumulation needs further investigations. " 3996 4123 W4311047860.pdf 9 15 separator 0.6502829 ¶ 4123 4124 W4311047860.pdf 9 16 text 0.9972322 "EndoMT has been also described in diabetic nephropathy, including in STZ induced rodent experimental nephropathy in which a-SMA presents as an important marker of their mesenchymal transitions (33). Similar to the report by Zeisberg et al., we observed colocalization of a-SMA and endothelial cell marker CD31, and increased a-SMA expression in diabetic kidneys with elevated amount of a-SMA+ endothelial cells in the diabetic glomeruli. Glucosamine reduced a-SMA expression in eyes in pathological conditions (34, 35). " 4124 4661 W4311047860.pdf 9 17 title 0.6612144 Similar 4661 4668 W4311047860.pdf 9 18 text 0.4893557 results 4668 4676 W4311047860.pdf 9 19 separator 0.9613943 ¶ 4676 4678 W4311047860.pdf 9 20 paratext 0.9632668 Frontiers in Nutrition 10 frontiersin.org 4678 4720 W4311047860.pdf 9 0 paratext 0.9905185 Mar. Drugs 2022 ,20, 729 4 of 14 0 32 W4309572142.pdf 3 1 separator 0.996143 ¶ 32 34 W4309572142.pdf 3 2 caption 0.98867697 "Figure 2. Effect of Ech A on lipid deposition. The lipid deposition was higher in the OVX groups but lower in the Ech A treatment groups. ( A) Lipid vacuoles (yellow arrows) were detected in the submandibular gland after H and E staining. We counted intracellular lipid vacuoles, primarily distributed between acini cells or in the cytoplasm of serous cells. ( B) Morphometric analysis of lipid vacuoles. ( C) Nile red staining of rat submandibular gland. Positive Nile red staining was revealed in the cytoplasm of acinar cells, increased in the OVX groups, and decreased in the ECH groups of in the cytoplasm of acinar cells. n= 8, each group. Error bar; S.D. One-way ANOVA; *** p< 0.001; vs. SHAM, # p< 0.05, ## p< 0.01; vs. OVX." 34 781 W4309572142.pdf 3 3 separator 0.9958936 ¶ 781 783 W4309572142.pdf 3 4 title 0.99361116 2.3. Ech A Inhibited the Expression of Lipid Metabolic Genes 783 844 W4309572142.pdf 3 5 separator 0.9954405 ¶ 844 846 W4309572142.pdf 3 6 text 0.9995251 "Several transcription factors and genes that are known to regulate lipid metabolism were investigated. The effects on sterol regulatory element-binding protein-1c (Srebp-1c) mRNA levels were initially explored. The Srebp-1c levels increased in the OVX groups but decreased significantly in the ECH-12 groups (Figure 3A). Subsequently, we examined whether Ech A treatment affected the expression of acetyl-CoA carboxylase (Acc) target genes (Figure 3B). The ACC is a lipid metabolic-related enzyme that catalyzes the irre- versible carboxylation of acetyl-CoA to malonyl-CoA [ 28]. The Acc mRNA expression was significantly higher in the OVX groups but decreased following Ech A treatment. A key enzyme in the endogenous lipogenesis pathway, fatty acid synthase (FASN), is also a Srebp-1c target gene [ 29]. Fasn mRNA expression was significantly higher in the OVX groups but reduced in the ECH groups (Figure 3C). The cluster of differentiation 36 (Cd36) enhances fatty acid uptake and promotes inflammation [ 28,29]. Cd36 mRNA expression was significantly elevated in the OVX groups, but Ech A treatment decreased the effects (Figure 3D). These findings could explain the reduction in lipid vacuoles in salivary gland tissues following Ech A treatment." 846 2122 W4309572142.pdf 3 0 paratext 0.9876488 Energies 2022 ,15, 3482 21 of 23 0 32 W4229445779.pdf 20 1 separator 0.49443394 32 33 W4229445779.pdf 20 2 paratext 0.95853984 ¶ Energies 2022 , 15, x FOR PEER REVIEW 21 of 23 33 81 W4229445779.pdf 20 3 separator 0.90539956 "¶ ¶ ¶" 82 97 W4229445779.pdf 20 4 title 0.81770945 (a) ( b) 97 106 W4229445779.pdf 20 5 separator 0.9918179 ¶ 107 109 W4229445779.pdf 20 6 caption 0.99188447 "Figure A2. Hydrogen fuel system energy use and wind energy generation under the parameter set of Appendix A, Table A3, for the ( a) Earl Thorfinn and ( b) Frisia III." 109 279 W4229445779.pdf 20 7 separator 0.99008614 ¶ 280 282 W4229445779.pdf 20 8 title 0.4922433 References 282 293 W4229445779.pdf 20 9 separator 0.9859535 ¶ 294 296 W4229445779.pdf 20 10 bibliography 0.99483085 "1. European Commission. Roadmap to A Single European Tran sport Area—Towards a Competitive and Resource Efficient Transport System ; COM(2011) 144 Final; European Commission: Brussels , Belgium, 2011. Available online: https://eur- lex.europa.eu/LexUriServ/LexUriServ.do?uri=COM :2011:0144:FIN:en:PDF (accessed on 9 May 2022)." 296 628 W4229445779.pdf 20 11 separator 0.920998 ¶ 629 631 W4229445779.pdf 20 12 bibliography 0.99665886 "2. International Maritime Organization (IMO). Initial IMO Strategy on Reduction of GHG Emissions from Ships ; MEPC.304(72): London, UK, 13 April 2018. 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Environ. 2014 , 91, 1–14. https://doi.org/10.1016/j.atmosenv.2014.03.006." 2514 2776 W4229445779.pdf 20 29 separator 0.9302963 ¶ 2777 2779 W4229445779.pdf 20 30 bibliography 0.99798745 "11. Jalkanen, J.-P.; Johansson, L.; Kukkonen, J.; Brink, A.; Kalli, J. ; Stipa, T. Extension of an assessment model of ship traffic exhaust emissions for particulate matter and carbon monoxide. Atmos. Chem. Phys. 2012 , 12, 2641–2659. https://doi.org/10.5194/acp-12- 2641-2012." 2779 3062 W4229445779.pdf 20 31 separator 0.9343892 ¶ 3063 3065 W4229445779.pdf 20 32 bibliography 0.99791896 "12. Jalkanen, J.-P.; Johansson, L.; Kukkonen, J. A comprehensive inve ntory of the ship traffic exhaus t emissions in the Baltic Sea from 2006 to 2009. Ambio 2014 , 43, 311–324. https://doi.org/10.1007/s13280-013-0389-3." 3065 3290 W4229445779.pdf 20 33 separator 0.9007596 ¶ 3291 3293 W4229445779.pdf 20 34 bibliography 0.9979098 "13. Jalkanen, J.-P.; Johansson, L.; Kukkonen, J. A comprehensive inventory of ship traffic exhaust emissions in the European sea areas in 2011. Atmos. Chem. Phys. 2016 , 16, 71–84. https://doi.org/10.5194/acp-16-71-2016." 3293 3518 W4229445779.pdf 20 35 separator 0.95944905 ¶ 3519 3521 W4229445779.pdf 20 36 bibliography 0.9967836 "14. International Maritime Organization (IMO). Third IMO Greenhouse Gas Study 2014. Available online: https://www.imo.org/en/OurWork/Envir onment/Pages/Greenhouse-Gas-Studie s-2014.aspx (accessed on 9 May 2022)." 3521 3736 W4229445779.pdf 20 37 separator 0.98005706 ¶ 3737 3739 W4229445779.pdf 20 38 caption 0.99284667 "Figure A2. Hydrogen fuel system energy use and wind energy generation under the parameter set of Appendix A, Table A3, for the ( a) Earl Thorfinn and ( b) Frisia III." 3739 3907 W4229445779.pdf 20 39 separator 0.98669946 ¶ 3907 3909 W4229445779.pdf 20 40 bibliography 0.5920972 References 3909 3920 W4229445779.pdf 20 41 separator 0.98585796 ¶ 3920 3922 W4229445779.pdf 20 42 bibliography 0.9968289 "1. European Commission. Roadmap to A Single European Transport Area—Towards a Competitive and Resource Efficient Transport System ; COM(2011) 144 Final; European Commission: Brussels, Belgium, 2011; Available online: https://eur-lex.europa.eu/LexUriServ/ LexUriServ.do?uri=COM:2011:0144:FIN:en:PDF (accessed on 5 May 2022)." 3922 4249 W4229445779.pdf 20 43 separator 0.8969957 ¶ 4249 4251 W4229445779.pdf 20 44 bibliography 0.997696 "2. International Maritime Organization (IMO). Initial IMO Strategy on Reduction of GHG Emissions from Ships ; MEPC.304(72): London, UK, 13 April 2018; Available online: https://unfccc.int/sites/default/files/resource/250_IMO%20submission_Talanoa%20 Dialogue_April%202018.pdf (accessed on 5 May 2022)." 4251 4555 W4229445779.pdf 20 45 separator 0.91286206 ¶ 4555 4557 W4229445779.pdf 20 46 bibliography 0.99757105 "3. Re ̧ sito ̆ glu, ̇I.A.; Altini ̧ sik, K.; Keskin, A. The pollutant emissions from diesel-engine vehicles and exhaust aftertreatment systems. Clean Technol. Environ. Policy 2015 ,17, 15–27. [CrossRef]" 4557 4759 W4229445779.pdf 20 47 separator 0.937292 ¶ 4759 4761 W4229445779.pdf 20 48 bibliography 0.9975075 "4. Hoen, A.; Nieuwenhuijse, I.; de Bruyn, S. Health Impacts and Costs of Diesel Emissions in the EU ; CE Delft: Delft, The Netherlands, 2018; Available online: https://cedelft.eu/publications/health-impacts-and-costs-of-diesel-emissions-in-the-eu/ (accessed on 5 May 2022)." 4761 5039 W4229445779.pdf 20 49 separator 0.881902 ¶ 5039 5041 W4229445779.pdf 20 50 bibliography 0.99748874 "5. Petrospot Ltd. Session 4: Supply chain stakeholders have their say on the energy transition. In Proceedings of the Ship Energy Summit, Online. 8 September 2021." 5041 5207 W4229445779.pdf 20 51 separator 0.87188286 ¶ 5207 5209 W4229445779.pdf 20 52 bibliography 0.9976682 "6. Gómez Trillos, J.C. HySeas III—Market Potential Analysis of RoPax Ferry Market in Europe ; Ref. Ares (2019)7435585; German Aerospace Centre (DLR): Oldenburg, Germany, 2019." 5209 5387 W4229445779.pdf 20 53 separator 0.75640696 ¶ 5387 5389 W4229445779.pdf 20 54 bibliography 0.9975684 "7. European Commission. THETIS-MRV CO 2Emission Report. Available online: https://mrv.emsa.europa.eu/#public/emission- report (accessed on 1 November 2020)." 5389 5548 W4229445779.pdf 20 55 separator 0.7014482 ¶ 5548 5550 W4229445779.pdf 20 56 bibliography 0.99775976 "8. Cooper, J. Fuels Europe—Statistical Report 2019 ; FuelsEurope: Brussels, Belgium, 2019; Available online: https://www.fuelseurope. eu/publication/statistical-report-2019/ (accessed on 5 May 2022)." 5550 5752 W4229445779.pdf 20 57 separator 0.88291246 ¶ 5752 5754 W4229445779.pdf 20 58 bibliography 0.9974688 "9. Kristensen, H.O.; Psaraftis, H. Energy Demand and Exhaust Gas Emissions of Marine Engines. 2015. Available online: https://www.danishshipping.dk/en/services/beregningsvaerktoejer/download/Basic_Model_Linkarea_Link/806/energy- demand-and-emissions-of-marine-engines-september-2015.pdf (accessed on 5 May 2022)." 5754 6071 W4229445779.pdf 20 59 separator 0.92835367 ¶ 6071 6073 W4229445779.pdf 20 60 bibliography 0.9978533 "10. Winther, M.; Christensen, J.H.; Plejdrup, M.S.; Ravn, E.S.; Eriksson, F.; Kristensen, H.O. Emission inventories for ships in the arctic based on satellite sampled AIS data. Atmos. Environ. 2014 ,91, 1–14. [CrossRef]" 6073 6295 W4229445779.pdf 20 61 separator 0.9339789 ¶ 6295 6297 W4229445779.pdf 20 62 bibliography 0.9978212 "11. Jalkanen, J.-P .; Johansson, L.; Kukkonen, J.; Brink, A.; Kalli, J.; Stipa, T. Extension of an assessment model of ship traffic exhaust emissions for particulate matter and carbon monoxide. Atmos. Chem. Phys. 2012 ,12, 2641–2659. [CrossRef]" 6297 6543 W4229445779.pdf 20 63 separator 0.92692983 ¶ 6543 6545 W4229445779.pdf 20 64 bibliography 0.99763656 "12. Jalkanen, J.-P .; Johansson, L.; Kukkonen, J. A comprehensive inventory of the ship traffic exhaust emissions in the Baltic Sea from 2006 to 2009. Ambio 2014 ,43, 311–324. [CrossRef]" 6545 6733 W4229445779.pdf 20 65 separator 0.900417 ¶ 6733 6735 W4229445779.pdf 20 66 bibliography 0.99762505 "13. Jalkanen, J.-P .; Johansson, L.; Kukkonen, J. A comprehensive inventory of ship traffic exhaust emissions in the European sea areas in 2011. Atmos. Chem. Phys. 2016 ,16, 71–84. [CrossRef]" 6735 6928 W4229445779.pdf 20 67 separator 0.9633739 ¶ 6928 6930 W4229445779.pdf 20 68 bibliography 0.99731153 "14. International Maritime Organization (IMO). Third IMO Greenhouse Gas Study. 2014. Available online: https://www.imo.org/ en/OurWork/Environment/Pages/Greenhouse-Gas-Studies-2014.aspx (accessed on 5 May 2022)." 6930 7144 W4229445779.pdf 20 69 separator 0.93943727 ¶ 7144 7146 W4229445779.pdf 20 70 bibliography 0.99704003 "15. International Maritime Organization (IMO). Fourth IMO Greenhouse Gas Study. 2020. Available online: https://www.imo.org/ en/OurWork/Environment/Pages/Fourth-IMO-Greenhouse-Gas-Study-2020.aspx (accessed on 9 April 2022)." 7146 7372 W4229445779.pdf 20 0 paratext 0.7899015 References 0 10 W2129027035.pdf 5 1 separator 0.96970105 ¶ 10 12 W2129027035.pdf 5 2 bibliography 0.99818504 "Ward, N.S., Brown, M.M., Thompson, A.J., Frackowiak, R.S.J., 2003. Neural correlates of outcome after stroke: a cross-sectional fMRI study. Brain 126, 1430 –1448." 12 177 W2129027035.pdf 5 3 separator 0.9287243 ¶ 177 179 W2129027035.pdf 5 4 bibliography 0.9981178 "Serrien, D.J., Strens, L.H.A., Cassidy, M.J., Thompson, A.J., Brown, P., 2004. Functional signif- icance of the ipsilateral hemisphere during movement of the affected hand after stroke. Experimental Neurology 190, 425 –432." 179 407 W2129027035.pdf 5 5 separator 0.9562068 ¶ 407 409 W2129027035.pdf 5 6 bibliography 0.998121 "Gerloff, C., Bushara, K., Sailer, A., Wassermann, E.M., Chen, R., Matsuoka, T., Waldvogel, D., Wittenberg, G.F., Ishii, K., Cohen, L.G., et al., 2006a. Multimodal imaging of brainreorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain 129, 791 –808." 409 726 W2129027035.pdf 5 7 separator 0.9508983 ¶ 726 728 W2129027035.pdf 5 8 bibliography 0.9981156 "Cramer, S.C., 2008. Repairing the human brain after stroke: I. Mechanisms of spontane- ous recovery. Annals of Neurology 63, 272 –287." 728 865 W2129027035.pdf 5 9 separator 0.96496725 ¶ 865 867 W2129027035.pdf 5 10 bibliography 0.9979197 "Johansen-Berg, H., Rushworth, M.F.S., Bogdanovic, M.D., Kischka, U., Wimalaratna, S., Matthews, P.M., 2002. The role of ipsilateral premotor cortex in hand movement after stroke. Proceedings of the National Academy of Sciences of the United States of America 99, 14518 –14523." 867 1150 W2129027035.pdf 5 11 separator 0.9578155 ¶ 1150 1152 W2129027035.pdf 5 12 bibliography 0.9952061 "Fridman, E.A., Hanakawa, T., Chung, M., Hummel, F., Leiguarda, R.C., Cohen, L.G., 2004. Reorganization of the human ipsilesional premotor cortex after stroke. Brain 127, 747–758." 1152 1335 W2129027035.pdf 5 13 separator 0.9549638 ¶ 1335 1337 W2129027035.pdf 5 14 bibliography 0.9981021 "Lotze, M., Markert, J., Sauseng, P., Hoppe, J., Plewnia, C., Gerloff, C., 2006. The role of mul- tiple contralesional motor areas for complex hand movements after internal capsular lesion. Journal of Neuroscience 26, 6096 –6102." 1337 1570 W2129027035.pdf 5 15 separator 0.9591986 ¶ 1570 1572 W2129027035.pdf 5 16 bibliography 0.9980674 "Murase, N., Duque, J., Mazzocchio, R., Cohen, L.G., 2004. In fluence of interhemispheric interactions on motor function in chronic stroke. 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Computational Intelligence and Neuroscience 67613." 5492 5634 W2129027035.pdf 5 49 separator 0.9581746 ¶ 5634 5636 W2129027035.pdf 5 50 bibliography 0.998132 "Van Veen, B.D., van Drongelen, W., Yuchtman, M., Suzuki, A., 1997. Localization of brain electrical activity via linearly constrained minimum variance spatial filtering. IEEE Transactions on Biomedical Engineering 44, 867 –880." 5636 5867 W2129027035.pdf 5 51 separator 0.9516274 ¶ 5867 5869 W2129027035.pdf 5 52 bibliography 0.99603844 "Gross, J., Kujala, J., Hamalainen, M., Timmermann, L., Schnitzler, A., Salmelin, R., 2001. Dynamic imaging of coherent sources: studying neural interactions in the human brain. Proceedings of the National Academy of Sciences of the United States of America 98, 694 –699." 5869 6146 W2129027035.pdf 5 53 separator 0.9148796 ¶ 6146 6148 W2129027035.pdf 5 54 bibliography 0.9980281 "Hotelling, H., 1931. The generalization of student's ratio. Annals of Mathematical Statis- tics 2, 360 –378." 6148 6259 W2129027035.pdf 5 55 separator 0.9561888 ¶ 6259 6261 W2129027035.pdf 5 56 bibliography 0.9972288 "Rosenberg, J.R., Amjad, A.M., Breeze, P., Brillinger, D.R., Halliday, D.M., 1989. The Fourier approach to the identi fication of functional coupling between neuronal spike trains. Progress in Biophysics and Molecular Biology 53, 1 –31." 6261 6500 W2129027035.pdf 5 57 separator 0.9606253 ¶ 6500 6502 W2129027035.pdf 5 58 bibliography 0.99806297 "Turton, A., Wroe, S., Trepte, N., Fraser, C., Lemon, R.N., 1996. Contralateral and ipsilateral EMG responses to transcranial magnetic stimulation during recovery of arm and hand function after stroke. Electroencephalography and Clinical Neurophysiology 101, 316 –328." 6502 6776 W2129027035.pdf 5 59 separator 0.9505646 ¶ 6776 6778 W2129027035.pdf 5 60 bibliography 0.9981179 "Netz, J., Lammers, T., Hömberg, V., 1997. Reorganization of motor output in the non- affected hemisphere after stroke. Brain 120 (Pt. 9), 1579 –1586." 6778 6930 W2129027035.pdf 5 61 separator 0.95210564 ¶ 6930 6932 W2129027035.pdf 5 62 bibliography 0.99805266 "Hansen, N.L., Nielsen, J.B., 2004. The effect of transcranial magnetic stimulation and pe- ripheral nerve stimulation on corticomuscular coherence in humans. The Journalof Physiology 561, 295 –306." 6932 7132 W2129027035.pdf 5 63 separator 0.96576154 ¶ 7132 7134 W2129027035.pdf 5 64 bibliography 0.9980315 "Soteropoulos, D.S., Edgley, S.A., Baker, S.N., 2011. Lack of evidence for direct corticospinal contributions to control of the ipsilateral forelimb in monkey. Journal of Neurosci- ence 31, 11208 –11219." 7134 7341 W2129027035.pdf 5 65 separator 0.955595 ¶ 7341 7343 W2129027035.pdf 5 66 bibliography 0.9975465 "Zaaimi, B., Edgley, S.A., Soteropoulos, D.S., Baker, S.N., 2012. Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey. Brain 135, 2277 –2289." 7343 7536 W2129027035.pdf 5 67 separator 0.966614 ¶ 7536 7538 W2129027035.pdf 5 68 bibliography 0.9978916 "Belhaj-Saïf, A., Cheney, P.D., 2000. Plasticity in the distribution of the red nucleus out- put to forearm muscles after unilateral lesions of the pyramidal tract. Journal of Neurophysiology 83, 3147 –3153." 7538 7749 W2129027035.pdf 5 69 separator 0.9627043 ¶ 7749 7751 W2129027035.pdf 5 70 bibliography 0.99799776 "Giboin, L.-S., Lackmy-Vallée, A., Burke, D., Marchand-Pauvert, V., 2012. Enhanced propriospinal excitation from hand muscles to wrist flexors during reach-to-grasp in humans. Journal of Neurophysiology 107, 532 –543." 7751 7971 W2129027035.pdf 5 71 separator 0.9609053 ¶ 7971 7973 W2129027035.pdf 5 72 bibliography 0.9980979 "Dum, R.P., Strick, P.L., 1996. Spinal cord terminations of the medial wall motor areas in macaque monkeys. Journal of Neuroscience 16, 6513 –6525." 7973 8122 W2129027035.pdf 5 73 separator 0.95704925 ¶ 8122 8124 W2129027035.pdf 5 74 bibliography 0.99812734 "Mima, T., Toma, K., Koshy, B., Hallett, M., 2001. Coherence between cortical and muscu- lar activities after subcortical stroke. Stroke 32, 2597 –2601." 8124 8278 W2129027035.pdf 5 75 separator 0.94650877 ¶ 8278 8280 W2129027035.pdf 5 76 bibliography 0.99677473 "Fang, Y., Daly, J.J., Sun, J., Hvorat, K., Fredrickson, E., Pundik, S., Sahgal, V., Yue, G.H., 2009. Functional corticomuscular connection during reaching is weakened following stroke. Clinical Neurophysiology 120, 994 –1002." 8280 8510 W2129027035.pdf 5 77 separator 0.9447175 ¶ 8510 8512 W2129027035.pdf 5 78 bibliography 0.99805117 "Engel, A.K., Fries, P., Singer, W., 2001. Dynamic predictions: oscillations and synchrony in top –down processing. Nature Reviews Neuroscience 2, 704 –716." 8512 8670 W2129027035.pdf 5 79 separator 0.9456711 ¶ 8670 8672 W2129027035.pdf 5 80 bibliography 0.99815404 "Tallon-Baudry, C., Bertrand, O., 1999. Oscillatory gamma activity in humans and its role in object representation. Trends in Cognitive Sciences 3, 151 –162.55 H.E. Rossiter et al. / NeuroImage: Clinical 2 (2013) 50 –55" 8672 8893 W2129027035.pdf 5 0 paratext 0.9870625 Al’Adl, Volume VIII Nomor 3, September - Desember 2016 ISSN 1979 - 4940 0 82 W2611074293.pdf 14 1 separator 0.892452 ¶ ¶ 84 90 W2611074293.pdf 14 2 paratext 0.85856813 109 91 95 W2611074293.pdf 14 3 title 0.66994095 seperti halnya menikmati tanah ulayat 95 135 W2611074293.pdf 14 4 text 0.6213905 ¶ mereka. 135 144 W2611074293.pdf 14 5 separator 0.9773741 ¶ 146 148 W2611074293.pdf 14 6 text 0.9979384 "Pengakuan hak ulayat dalam perdasus ini memakai logika hukum nasional yaitu yang bersumber dari pemerintah. Pengakuan yang berujung pada penetapan pemerintah (Bupati/Walikota/G ubernur) didahului serangkaian penelitian oleh tim yang ditetapkan oleh keputusan pemerintah." 148 440 W2611074293.pdf 14 7 separator 0.9590602 ¶ 441 443 W2611074293.pdf 14 8 text 0.9971543 "Posisi kunci ada atau tidaknya hak ulayat masyarakat hukum adat di lokasi yang diteliti oleh tim ada di tangan pemerintah, meskipun tidak secara tegas disebutkan kewenangan pemerintah untuk menolak mengeluarkan penetapan keberadaan masyarakat hukum adat. Ketika masyarakat hukum adat memperoleh pengakuan baik menyangkut identitas maupun wilayah adatnya, terbuka ruang bagi masyarakat hukum adat untuk melakukan pengelo laan. Pengelolaan ulayat ini diatur dalam Bab IV yang mengatur pengelolaan hak ulayat masyarakat hukum adat dan atau hak perorangan warga masyarakat hukum adat atas tanah, Pasal 8 sampai dengan Pasal 12." 443 1118 W2611074293.pdf 14 9 separator 0.9916601 ¶ 1120 1122 W2611074293.pdf 14 10 text 0.9679345 "Model -model yang dikembangkan dalam konteks pengelo laan ini adalah pola pemanfaatan seperti yang dimuat pada pasal 8 yang menyebutkan bahwa: (1) Berdasarkan Keputusan Bupati/Walikota dan atau Gubernur yang menetapkan bahwa hak ulayat masyarakat hukum adat dan atau hak perorangan warga masyarakat hukum adat ata s tanah masih ada, maka masyarakat hukum adat dan atau perorangan warga masyarakat hukum adat yang bersangkutan berwenang untuk : " 1122 1606 W2611074293.pdf 14 11 separator 0.50552833 ¶ 1606 1607 W2611074293.pdf 14 12 text 0.97993255 "a) melaksanakan pengelolaan hak ulayat masyarakat hukum adat dan atau hak perorangan warga masyarakat hukum adat atas tanah sesua i dengan hukum adat yang berlaku dalam masyarakat hukum adat yang bersangkutan. Dalam pengelolaan hak ulayat masyarakat hukum adat dan atau hak perorangan warga masyarakat hukum adat atas tanah, tidak boleh bertentangan dengan ketentuan peraturan perundang -undangan. b) melakukan musyawarah dengan pihak ketiga diluar warga masyarakat hukum adat yang memerlukan tanah untuk berbagai kepentingan. Hasilmusyawarahdenganpihakk etigatersebutdapatberupa:" 1607 2248 W2611074293.pdf 14 0 paratext 0.9887388 Plants 2024 ,13, 994 9 of 18 0 28 W4393387912.pdf 8 1 separator 0.99533474 ¶ 28 30 W4393387912.pdf 8 2 text 0.99914175 "Moreover, based on our correlation analysis, we found that SmSnRK2.6 was related to tan- shinones biosynthesis, indicating that SmSnRK2.6 may participate in tanshinones biosynthe- sis. To investigate whether SmSnRK2.6 participated in regulating tanshinone biosynthesis, we silenced SmSnRK2.6 expression in transgenic hairy root lines with the RNAi method." 30 392 W4393387912.pdf 8 3 separator 0.9669563 ¶ 392 394 W4393387912.pdf 8 4 text 0.99892753 "Ri-2.6-5, Ri-2.6-7 and Ri-2.6-8 with substantial a down-regulation of SmSnRK2.6 expression were selected for further study (Figure S5). The phenotype and extract color of hairy roots hinted that the content of tanshinones in Ri-SmSnRK2.6 strains was lower than that in the control strain (Figure 8a,b). Metabolic content analysis showed that the content of dihydrotanshinone (DHT), cryptotanshinone (CT), tanshinone I (TI) and tanshinone IIA (TIIA) in the control lines was about 2.54–4.33, 2.28–6.29, 1.83–2.26 and 1.83–2.26 times higher than in the Ri-SmSnRK2.6 lines, respectively (Figure 8c). Moreover, the expression level of most tanshinone biosynthetic genes was decreased in the Ri-SmSnRK2.6 lines, among which SmGGPPS1 and SmCPS1 were significantly down-regulated, with the lowest decrease of 0.26- and 0.43-fold that of the control lines, respectively (Figure 8d). These results confirmed that SmSnRK2.6 positively regulated tanshinone biosynthesis." 394 1374 W4393387912.pdf 8 5 separator 0.97915626 ¶ 1374 1376 W4393387912.pdf 8 6 paratext 0.98670435 Plants 2024 , 13, x FOR PEER REVIEW 11 of 20 1376 1421 W4393387912.pdf 8 7 separator 0.962825 ¶ ¶ 1422 1428 W4393387912.pdf 8 8 text 0.9909127 "control lines, respectively (Figure 8d). These results con firmed that SmSnRK2.6 posi- tively regulated tanshinone biosynthesis." 1429 1559 W4393387912.pdf 8 9 separator 0.9719632 ¶ ¶ 1561 1567 W4393387912.pdf 8 10 caption 0.99569184 "Figure 8. SmSnRK2.6 is a positive regulato r of tanshinone biosynthesis. ( a) The phenotypes of hairy roots (Ri-EV and Ri-SmSnRK2.6 hairy root lin es) pictured after 45 d cultured in 1/2 MS liq- uid medium. Scale bar, 1 cm. ( b) Representative images showing th e extracts of tanshinones of ( a)." 1567 1869 W4393387912.pdf 8 11 separator 0.71160686 ¶ 1870 1872 W4393387912.pdf 8 12 caption 0.9071608 "(c) Determination of CT, TIIA, DHT, and TI in the hairy roots (Ri-EV and Ri-SmSnRK2.6 hairy root lines). ( d) Relative expression of tanshinone bios ynthesis structural genes in Ri-EV and Ri-SmSnRK2.6 lines. Actin was used as an internal reference gene." 1872 2133 W4393387912.pdf 8 13 text 0.49957943 All data 2133 2142 W4393387912.pdf 8 14 caption 0.51330364 represent the means 2142 2162 W4393387912.pdf 8 15 text 0.3767011 2162 2163 W4393387912.pdf 8 16 caption 0.33874086 ± 2163 2164 W4393387912.pdf 8 17 text 0.41121665 2165 2166 W4393387912.pdf 8 18 table 0.43870968 ¶ 2166 2167 W4393387912.pdf 8 19 text 0.6437434 "SD of three biological re plicates. Statistical signi ficance was determined based on Student’s t-test (* p < 0.05 and ** p < 0.01)." 2167 2302 W4393387912.pdf 8 20 separator 0.996705 ¶ 2303 2305 W4393387912.pdf 8 21 title 0.9934227 2.7. SmSnRK2.2 Interacts with and Phosphorylates SmAREB1 2305 2362 W4393387912.pdf 8 22 separator 0.99566215 ¶ 2363 2365 W4393387912.pdf 8 23 text 0.99972034 "A previous study has shown that SmSnRK2.3 and SmSnRK2.6 interacted with SmAREB1 [49]. To test whether SmSnRK2.2 in teracts with SmAREB1, yeast two hybrid (Y2H) assays and bimolecular fluorescence complementation (BiFc) assays were applied." 2365 2610 W4393387912.pdf 8 24 separator 0.9444632 ¶ 2611 2613 W4393387912.pdf 8 25 text 0.9997215 Y2H assays showed that SmSnRK2.2 interacts with SmAREB1 in yeast (Figure 9a). BiFc assays showed that SmSnRK2.2 can interact with SmAREB1 in plant cells (Figure 9b). 2613 2779 W4393387912.pdf 8 26 separator 0.90426964 ¶ 2780 2782 W4393387912.pdf 8 27 text 0.99957186 "Furthermore, we also tested whether SmSnRK2.2 could phosphorylate SmAREB1 by us- ing a Phos-tag reagent. As shown in Figure 9c, the mobility shift was quite slow com- pared with the control, indicating that SmSnRK2.2 could phosphorylate SmAREB1 in vitro." 2782 3044 W4393387912.pdf 8 28 separator 0.99606264 ¶ 3045 3047 W4393387912.pdf 8 29 caption 0.9961875 "Figure 8. SmSnRK2.6 is a positive regulator of tanshinone biosynthesis. ( a) The phenotypes of hairy roots (Ri-EV and Ri-SmSnRK2.6 hairy root lines) pictured after 45 d cultured in 1/2 MS liquid medium. Scale bar, 1 cm. ( b) Representative images showing the extracts of tanshinones of ( a)." 3047 3343 W4393387912.pdf 8 30 separator 0.66031945 ¶ 3343 3345 W4393387912.pdf 8 31 caption 0.9289686 "(c) Determination of CT, TIIA, DHT, and TI in the hairy roots (Ri-EV and Ri-SmSnRK2.6 hairy root lines). ( d) Relative expression of tanshinone biosynthesis structural genes in Ri-EV and Ri-SmSnRK2.6 lines. Actin was used as an internal reference gene." 3345 3602 W4393387912.pdf 8 32 text 0.51252484 All data 3602 3611 W4393387912.pdf 8 33 caption 0.44944245 represent the means 3611 3632 W4393387912.pdf 8 34 text 0.4047995 ±SD of 3632 3638 W4393387912.pdf 8 35 caption 0.3993294 three 3638 3644 W4393387912.pdf 8 36 text 0.62592447 "¶ biological replicates. Statistical significance was determined based on Student’s t-test (* p< 0.05 and **p< 0.01)." 3644 3764 W4393387912.pdf 8 37 separator 0.9967331 ¶ 3764 3766 W4393387912.pdf 8 38 title 0.9938827 2.7. SmSnRK2.2 Interacts with and Phosphorylates SmAREB1 3766 3823 W4393387912.pdf 8 39 separator 0.9957912 ¶ 3823 3825 W4393387912.pdf 8 40 text 0.9996939 "A previous study has shown that SmSnRK2.3 and SmSnRK2.6 interacted with SmAREB1 [ 49]. To test whether SmSnRK2.2 interacts with SmAREB1, yeast two hybrid (Y2H) assays and bimolecular fluorescence complementation (BiFc) assays were applied." 3825 4069 W4393387912.pdf 8 41 separator 0.9722948 ¶ 4069 4071 W4393387912.pdf 8 42 text 0.9995562 Y2H assays showed that SmSnRK2.2 interacts with SmAREB1 in yeast (Figure 9a). BiFc 4071 4154 W4393387912.pdf 8 0 paratext 0.9737425 "International Journal of Forest Sciences ¶ (2023 )." 0 57 W4323927586.pdf 0 1 separator 0.5458409 ¶ 58 60 W4323927586.pdf 0 2 paratext 0.68806815 "3(1 ): 12 - 17 " 60 88 W4323927586.pdf 0 3 table 0.28204885 ¶ 88 89 W4323927586.pdf 0 4 paratext 0.5553829 12 89 92 W4323927586.pdf 0 5 table 0.295479 ¶ 92 94 W4323927586.pdf 0 6 separator 0.5353558 "¶ ¶ ¶" 96 110 W4323927586.pdf 0 7 title 0.813688 Diversity of Herptiles in Bagh, Azad Jammu and Kashmir, Pakistan 110 175 W4323927586.pdf 0 8 separator 0.8267142 "¶ ¶" 175 185 W4323927586.pdf 0 9 contact 0.9767873 "Nargis Sultan 1* , Saba Adil 1 ¶ and Asma Nawaz 1 ¶ 1. ¶ Department of Zoology, Women University of Azad Jammu and Kashmir, Bagh, Pakistan ¶ 2. ¶ Department of Zoology, University of Lahore, Sargodha Campus, Sargodha, Pakistan ¶ 3. ¶ Department of Zoology, Government College University, Faisalabad, Pakistan ¶ *Corresponding author e - mail: ¶ nargissultan715@yahoo.com ¶ ¶" 185 625 W4323927586.pdf 0 10 paratext 0.30819365 "¶ " 627 636 W4323927586.pdf 0 11 math 0.27475715 ¶ 636 637 W4323927586.pdf 0 12 paratext 0.316741 639 640 W4323927586.pdf 0 13 math 0.30458367 ¶ 640 641 W4323927586.pdf 0 14 paratext 0.2961696 643 644 W4323927586.pdf 0 15 math 0.3271764 ¶ 644 645 W4323927586.pdf 0 16 paratext 0.2746194 647 648 W4323927586.pdf 0 17 math 0.32446685 "¶ ¶ ¶ ¶ ¶ ¶" 648 685 W4323927586.pdf 0 18 separator 0.2880483 687 688 W4323927586.pdf 0 19 math 0.2989389 ¶ 688 689 W4323927586.pdf 0 20 separator 0.7355422 "¶ ¶ ¶" 691 705 W4323927586.pdf 0 21 title 0.9866311 INTRODUCTION 705 718 W4323927586.pdf 0 22 separator 0.9201096 ¶ ¶ 718 724 W4323927586.pdf 0 23 text 0.9971643 "Pakistan occurs a main geographic place (Sengor, 1985) and covers an area of 796,096 km 2 ¶ and is present in three zoogeographical zones (i.e., Palearctic, Oriental and Ethiopian). It stretches from longitude 60 o ¶ to 75 o ¶ E as well as latitude 24 o ¶ to 37 o ¶ N. Its southwest border is connected to the Arabian Sea, while its north end is located in th e stable snow scenery of Pamir in the vast Himalayan region (Khan, 2006). The mountains and plateaus in the west, north, and northwest represent the major mountain. Its mountainous topography has had a significant impact on the climate, geology, hydrology, ¶ and physiography, as well as the distribution and composition of fauna and plants in the contemporary age (Khan, 2006). The other part in salt variety and base of Himalayas; it is one of earliest division of the subcontinents. It acts as earliest Tethys S ea (Powell, 1979; Khan, 2006). ¶ Ten thousand four hundred and fifty species of reptiles are reported in the world (Utez, 2016); while 195 species present in Pakistan; belonging to 23 families (Khan, 2004, 2006). Pakistan has nine amphibian and thirteen rept ile species (Khan et" 724 1959 W4323927586.pdf 0 24 separator 0.7715453 ¶ 1960 1962 W4323927586.pdf 0 25 paratext 0.92534345 "Research ¶ Paper ¶ ¶ ¶ ¶ ¶ ¶ Open Access" 1962 2050 W4323927586.pdf 0 26 separator 0.9614057 ¶ ¶ 2050 2056 W4323927586.pdf 0 27 title 0.98005176 SUMMARY 2056 2064 W4323927586.pdf 0 28 separator 0.95778215 ¶ ¶ 2064 2070 W4323927586.pdf 0 29 text 0.9700251 "There are 10,450 reptile species recognized worldwide. There are 195 reptile species belong to ¶ 23 families. Pakistan is home to 13 reptile and 9 amphibian species. Several amphibian and reptile species have become extinct as a result of either direct or indirect anthropogenic effect. The research's aims were to estimate the variety of the studied r egion. ¶ During the study, total 16 herptiles species were documented, Hemidactylus brookii ¶ were noted with the highest relative (0.427419) and followed by Calotes versicolor ¶ (0.112903) , Bufo himalayanus (0.104839) , Amphiesma stolatum" 2070 2716 W4323927586.pdf 0 30 table 0.52061695 ¶ 2717 2719 W4323927586.pdf 0 31 text 0.75807804 "(0.072581) , Hemidactylu" 2719 2746 W4323927586.pdf 0 32 table 0.53482425 2746 2747 W4323927586.pdf 0 33 text 0.7770722 ¶ s flaviviridis 2747 2763 W4323927586.pdf 0 34 table 0.6504832 ¶ 2764 2766 W4323927586.pdf 0 35 text 0.57599473 (0.07 2766 2772 W4323927586.pdf 0 36 table 0.58192664 2581 2772 2776 W4323927586.pdf 0 37 text 0.51321787 ) 2776 2777 W4323927586.pdf 0 38 table 0.58769023 ¶ 2777 2779 W4323927586.pdf 0 39 text 0.7548487 , Ptyas 2779 2788 W4323927586.pdf 0 40 table 0.4852963 mucosus 2788 2795 W4323927586.pdf 0 41 text 0.50804096 2795 2796 W4323927586.pdf 0 42 table 0.51628464 muco 2796 2800 W4323927586.pdf 0 43 text 0.5080401 sus 2800 2803 W4323927586.pdf 0 44 table 0.7333625 ¶ 2804 2806 W4323927586.pdf 0 45 text 0.60140073 (0.04 2806 2812 W4323927586.pdf 0 46 table 0.58475834 0323) ¶ 2812 2819 W4323927586.pdf 0 47 text 0.6552214 , Varanus bengalensis 2819 2841 W4323927586.pdf 0 48 table 0.6601788 "¶ (0.032258) ," 2842 2859 W4323927586.pdf 0 49 text 0.69764024 Scincella himalayana 2859 2880 W4323927586.pdf 0 50 table 0.68080103 "¶ (0.032258) ," 2881 2898 W4323927586.pdf 0 51 text 0.69003534 Laudakia 2898 2907 W4323927586.pdf 0 52 table 0.7427383 ¶ agro 2908 2915 W4323927586.pdf 0 53 text 0.51301426 r 2915 2916 W4323927586.pdf 0 54 table 0.7099676 "ensis (0.024194) ," 2916 2939 W4323927586.pdf 0 55 text 0.62240744 Euble 2939 2945 W4323927586.pdf 0 56 table 0.5059718 p 2945 2946 W4323927586.pdf 0 57 text 0.6035884 hari 2946 2950 W4323927586.pdf 0 58 table 0.5012233 s 2950 2952 W4323927586.pdf 0 59 text 0.5330471 macularius 2952 2962 W4323927586.pdf 0 60 table 0.71066976 "¶ (0.016129) , Xenoch" 2963 2987 W4323927586.pdf 0 61 text 0.57318723 ro 2987 2989 W4323927586.pdf 0 62 table 0.7825344 "phis piscator piscator (0.016129) ," 2989 3029 W4323927586.pdf 0 63 text 0.55850196 Gloyd 3029 3035 W4323927586.pdf 0 64 table 0.768435 "ius himalayanus ¶ (0.016129) ," 3035 3071 W4323927586.pdf 0 65 text 0.4938206 Bungarus 3071 3080 W4323927586.pdf 0 66 table 0.76163036 "caeruleus caeruleus (0.008065) ," 3080 3118 W4323927586.pdf 0 67 text 0.49606323 Er 3118 3121 W4323927586.pdf 0 68 table 0.6916956 "yx johni (0.008065) ," 3121 3150 W4323927586.pdf 0 69 text 0.56178474 Spalero 3150 3158 W4323927586.pdf 0 70 table 0.6963306 "sophis diadema diadema (0.008065) ¶" 3158 3200 W4323927586.pdf 0 71 text 0.5757363 and Daboia 3200 3211 W4323927586.pdf 0 72 table 0.5720933 russelii russelii ¶ 3211 3232 W4323927586.pdf 0 73 text 0.5821562 (0.008065). 3232 3244 W4323927586.pdf 0 74 separator 0.8620602 ¶ 3245 3247 W4323927586.pdf 0 75 text 0.9858976 "It is found that the district Bagh contai ns a diverse range of herptiles ." 3247 3327 W4323927586.pdf 0 76 separator 0.84355235 ¶ ¶ 3327 3333 W4323927586.pdf 0 77 paratext 0.6483453 Keywords 3333 3342 W4323927586.pdf 0 78 text 0.48786294 : 3342 3343 W4323927586.pdf 0 79 separator 0.34919968 3343 3344 W4323927586.pdf 0 80 text 0.32586768 ¶ 3344 3345 W4323927586.pdf 0 81 paratext 0.32449323 3347 3348 W4323927586.pdf 0 82 text 0.35464406 ¶ Amp 3348 3353 W4323927586.pdf 0 83 paratext 0.2891431 hibi 3353 3357 W4323927586.pdf 0 84 title 0.28536353 an 3357 3359 W4323927586.pdf 0 85 text 0.42631805 , 3359 3360 W4323927586.pdf 0 86 paratext 0.34491777 Reptiles 3360 3369 W4323927586.pdf 0 87 text 0.48495355 , 3369 3370 W4323927586.pdf 0 88 paratext 0.41212636 Diversity 3370 3380 W4323927586.pdf 0 89 text 0.4835505 , 3380 3381 W4323927586.pdf 0 90 paratext 0.4545728 Bagh 3381 3386 W4323927586.pdf 0 91 text 0.33282763 , 3386 3387 W4323927586.pdf 0 92 paratext 0.5840478 Pakistan 3387 3396 W4323927586.pdf 0 93 separator 0.4276059 3396 3397 W4323927586.pdf 0 94 paratext 0.40349004 ¶ ¶ 3397 3402 W4323927586.pdf 0 95 separator 0.5007219 ¶ 3404 3406 W4323927586.pdf 0 96 paratext 0.9237046 Citation: 3406 3416 W4323927586.pdf 0 97 separator 0.83879673 ¶ ¶ 3416 3422 W4323927586.pdf 0 98 bibliography 0.96012616 Sultan, N., S. Adil, A. Nawaz. 2023. Diversity of Herptiles in Bagh, Azad Jammu and Kashmir, Pakistan. 3422 3525 W4323927586.pdf 0 99 separator 0.88911045 ¶ 3526 3528 W4323927586.pdf 0 100 paratext 0.9484338 "International Journal of Forest Sciences. 3: 12 - 17. ¶ Received: ¶ January, 2023 ; Accepted : February, 2023" 3528 3663 W4323927586.pdf 0 101 separator 0.9773789 ¶ ¶ 3663 3669 W4323927586.pdf 0 0 paratext 0.97145724 "Wind Energ. Sci., 8, 125–139, 2023 https://doi.org/10.5194/wes-8-125-2023 © Author(s) 2023. This work is distributed under the Creative Commons Attribution 4.0 License." 0 174 W4311785946.pdf 0 1 separator 0.99431247 ¶ 174 176 W4311785946.pdf 0 2 title 0.99209684 "Turbulence structures and entrainment length scales in large offshore wind farms" 176 259 W4311785946.pdf 0 3 separator 0.9916953 ¶ 259 261 W4311785946.pdf 0 4 contact 0.9818934 "Abdul Haseeb Syed1, Jakob Mann1, Andreas Platis2, and Jens Bange2 1Department of Wind and Energy Systems, Technical University of Denmark, 4000 Roskilde, Denmark 2Environmental Physics, Geo- and Environmental Center, Eberhard Karls University of Tübingen, 72076 Tübingen, Germany" 261 547 W4311785946.pdf 0 5 separator 0.6246599 ¶ 547 549 W4311785946.pdf 0 6 contact 0.9954783 Correspondence: Abdul Haseeb Syed (absy@dtu.dk) 549 597 W4311785946.pdf 0 7 separator 0.9072499 ¶ 597 599 W4311785946.pdf 0 8 paratext 0.9704009 "Received: 25 July 2022 – Discussion started: 30 August 2022 Revised: 15 December 2022 – Accepted: 11 January 2023 – Published: 24 January 2023" 599 744 W4311785946.pdf 0 9 separator 0.99460095 ¶ 744 746 W4311785946.pdf 0 10 text 0.9867247 "Abstract. The flow inside and around large offshore wind farms can range from smaller structures associated with the mechanical turbulence generated by wind turbines to larger structures indicative of the mesoscale flow." 746 967 W4311785946.pdf 0 11 separator 0.80821705 ¶ 967 969 W4311785946.pdf 0 12 text 0.99860644 "In this study, we explore the variation in turbulence structures and dominant scales of vertical entrainment above large offshore wind farms located in the North Sea, using data obtained from a research aircraft. The aircraft was flown upstream, downstream, and above wind farm clusters. Under neutrally stratified conditions, there is high ambient turbulence in the atmosphere and an elevated energy dissipation rate compared to stable conditions." 969 1422 W4311785946.pdf 0 13 separator 0.90135217 ¶ 1422 1424 W4311785946.pdf 0 14 text 0.99969834 "The intensity of small-scale turbulence structures is increased above and downstream of the wind farm, and it prevails over mesoscale fluctuations. But in stable stratification, mesoscale flow structures are not only dominant upstream of the wind farm but also downstream. We observed that the vertical flux of horizontal momentum is the main source of energy recovery in large offshore wind farms, and it strongly depends on the magnitude of the length scales of the vertical wind velocity component. The dominant length scales of entrainment range from 20 to60 m above the wind farm in all stratification strengths, and in the wake flow these scales range from 10 to 100 m only under near-neutral stratification. For strongly stable conditions, negligible vertical entrainment of momentum was observed even just 2 km downstream of large wind farms. We also observed that there is a significant lateral momentum flux above the offshore wind farms, especially under strongly stable conditions, which suggests that these wind farms do not satisfy the conditions of an “infinite wind farm”." 1424 2523 W4311785946.pdf 0 15 separator 0.9967437 ¶ 2523 2525 W4311785946.pdf 0 16 title 0.982389 1 Introduction 2525 2540 W4311785946.pdf 0 17 separator 0.995869 ¶ 2540 2542 W4311785946.pdf 0 18 text 0.99948514 "The flow inside and around large wind farms is characterized by a wide range of spatio-temporal turbulence structures. The flow structures are not only influenced by the mechanical tur- bulence generated by wind turbines but also by the ambient turbulence present in the atmosphere (Meyers and Meneveau, 2013). Many numerical and analytical studies have been per- formed to understand the interactions between wind farms and atmospheric flow (e.g., Porté-Agel et al., 2020; Stevens and Meneveau, 2017). Liu et al. (2018) suggested from their experiment inside a wind tunnel that integral timescales in the wind flow are decreased significantly above their mod- eled wind farm due to the development of an internal bound-ary layer and increase in turbulence above the wind farm. The atmospheric stratification also plays a significant role in the development of internal boundary layers (Savelyev and Tay- lor, 2005) and the evolution of turbulence structures down- stream of large wind farms. Wu and Porté-Agel (2017) de- scribed the effects of different free atmospheric stratification strengths on the upstream blockage and downstream wake lengths for large hypothetical wind farms using large-eddy simulations (LESs). Their results showed that wind farms experience an increased blockage effect during strong atmo- spheric stratifications, because of subcritical flow induced by wind farms i.e., the inertial forces cannot overcome the gravity-induced forces leading to Froude number Fr< 1." 2542 4071 W4311785946.pdf 0 19 separator 0.5851858 ¶ 4071 4073 W4311785946.pdf 0 20 text 0.996974 Much longer downstream wakes are also observed in ob- 4073 4127 W4311785946.pdf 0 21 separator 0.9300584 ¶ 4127 4129 W4311785946.pdf 0 22 paratext 0.91811174 Published by Copernicus Publications on behalf of the European Academy of Wind Energy e.V. 4129 4220 W4311785946.pdf 0 0 text 0.99968714 "NNEI-2-naphthyl-isomer ( 7), was a much weaker CB 1 receptor ligand and also showed only partial inhibition of radioligand binding at the CB 2receptor. NNEI ( 4), which was first described by Blaazer et al. [ 33] in 2011, showed a pKivalue of 8.9 in their binding experiments at the CB 1 receptor, which we have now confirmed. The authors alsosynthesized a non-fluorinated derivative of compound 7 (5F-NNEI-2-naphthyl-isomer) which displayed a lower pK i value of 7.2 for the CB 1receptor. The same relation could be shown in the present study [compare 5F-NNEI ( 5) and 5F-NNEI-2-naphthyl-isomer ( 7)]; if the naphthyl residue is linked in 2-position to the amide, the affinity was decreasedby about 100-fold." 0 727 W2404390137.pdf 8 1 separator 0.98179954 ¶ 727 729 W2404390137.pdf 8 2 text 0.99970245 "Huffman et al. [ 13] investigated the effects of substi- tuting the naphthyl ring by smaller aromatic residues,which reduced affinity to the CB 1receptor. This could also be observed for the benzyl-substituted compounds SDB- 006 ( 12) and 5F-SDB-006 ( 13) investigated in the present study. They showed much lower affinity for both CB receptors as compared to the napthyl-substituted com- pounds with Kivalues in the high nanomolar range. The phenyl-substituted derivative SDB-006- N-phenyl-analog (14) displayed even higher Kivalues. In group Ccom- pounds, RCS-4 ( 33) and RCS-8 ( 34) also feature a phenyl or a benzyl residue. Wiley et al. [ 34] described that the substitution in the ortho -position is crucial for high affinity, which is realized in both compounds. RCS-8 ( 34), first described in 2012 in the USA [ 35], is benzyl-substituted in position 1 and has a cyclohexylethyl residue in position 2; it shows weaker affinity for both CB receptors than RCS-4.RCS-4 and isomers were investigated by Banister et al. [36] who found that RCS-4 ( 33) displayed EC 50values of 145 nM for CB 1and 46 nM for CB 2. In the present study, RCS-4 ( 33) with Kivalues of 26.6 nM for CB 1and 2.86 nM for CB 2displayed higher binding affinities." 729 2004 W2404390137.pdf 8 3 separator 0.9809334 ¶ 2004 2006 W2404390137.pdf 8 4 text 0.99974704 "The aromatic residue R1may be replaced by a more bulky lipophilic group, namely an adamantyl or a tetram- ethylcyclopropyl residue. Comparing the naphthyl deriva- tives NNEI ( 4) and 5F-NNEI ( 5) with the adamantyl derivatives APICA ( 15) and STS-135 ( 16), it can be observed that CB 2affinity was increased. Also, the tetramethylcyclopropyl derivatives of group C displayed,independently of the side-chain variations, a CB 2prefer- ence. Compounds UR-144 ( 37), A-796,260 ( 45), A-834,735 ( 46) and XLR-12 ( 41) were first described by Frost et al. [ 29] in the search for selective CB 2agonists." 2006 2623 W2404390137.pdf 8 5 separator 0.9767702 ¶ 2623 2625 W2404390137.pdf 8 6 text 0.9997667 "We could confirm the reported Kivalues, but only XLR-12 (41) displayed a 10-fold higher Kivalue in our hands as compared to the literature data. From this group of com- pounds, some derivatives emerged on the illicit drug market, mainly in Sweden [ 37,38]. FAB-144 ( 40), the indazole and 5-fluoropentyl analogue of UR-144 ( 37), showed slightly increased affinity for both CB receptors,and FUB-144 ( 42), the para -fluorobenzyl derivative dis- played similar affinity. Also, compound M-144 ( 47), which is substituted in position 2 of the indole ring system with a methyl group, displayed a similar profile. AB-005 ( 43), a chimeric compound with the CB 2selectivity-increasing tetramethylcyclopropyl residue for R1and N-methyl-2- piperidinylmethyl substitution as R2which retains CB 1 affinity, was first introduced by Frost et al. in 2010 [ 29]. A derivative with an azepane ring ( 44) appeared on the illicit drug market, but as we found, it displayed no affinity for the CB 1receptor at concentrations up to 10 lM. If it should exert any psychotropic effect, it would not be mediated viathis receptor. At CB 2receptors, a moderate affinity was observed for 44. A structurally related but more potent compound is MN-25 ( 48), which was introduced by Wro- belenski et al. [ 39]; it was reported to be abused in previous years [ 39]." 2625 3995 W2404390137.pdf 8 7 separator 0.9856835 ¶ 3995 3997 W2404390137.pdf 8 8 text 0.9996044 "In summary, almost all investigated compounds showed high affinity for CB receptors. Some compounds displayed Kivalues in the subnanomolar range and, thus, are many times more potent than the psychoactive drug D9-THC." 3997 4220 W2404390137.pdf 8 9 separator 0.9958949 ¶ 4220 4222 W2404390137.pdf 8 10 title 0.99327004 Functional properties of investigated compounds 4222 4270 W2404390137.pdf 8 11 separator 0.9944632 ¶ 4270 4272 W2404390137.pdf 8 12 text 0.9997541 "To investigate the functional properties of the compounds, cAMP accumulation assays were performed. Both CB receptors are G i-coupled receptors, whose activation results in decreased cAMP levels in the cell. For comparison, the full agonist CP55,940 and the partial agonist D9-THC were investigated, and results were normalized to maximalreceptor activation by the full agonist CP55,940 (see Fig. 2)." 4272 4683 W2404390137.pdf 8 13 separator 0.85466224 ¶ 4683 4685 W2404390137.pdf 8 14 text 0.9997406 "Compounds were tested at a concentration where maximal binding was observed, either at 1 lM for the more potent compounds or at 10 lM for the less potent compounds." 4685 4854 W2404390137.pdf 8 15 separator 0.93631333 ¶ 4854 4856 W2404390137.pdf 8 16 text 0.9997426 "In the utilized recombinant cell lines, D 9-THC behaved as a partial agonist, at both CB 1and CB 2receptors, with 60–70 % activation as compared to the full CB 1/CB 2 agonist CP55,940 ( 2). Almost all compounds showed a high degree of activation of both receptor subtypes.Exceptions were 3-CAF ( 21) and AB-005 azepane isomer (44), which did not activate the CB receptors at all. As both compounds showed affinity for the CB 2receptor, they may be characterized as moderately potent CB 2-selective antagonists. The only agonistic compounds with lower efficacy than D9-THC were NNEI-2-naphthyl isomer ( 7), MN-18 ( 8), XLR-12 ( 41) and AB005 ( 43). Most of the compounds had similar efficacies at both receptor sub- types; only 5F-APINACA ( 17) activated CB 1receptor more efficaciously than CB 2." 4856 5679 W2404390137.pdf 8 17 separator 0.96112597 ¶ 5679 5681 W2404390137.pdf 8 18 text 0.9996333 "For the CB 2-selective derivative XLR-12 ( 41), full concentration response curves were recorded and EC 50 values were determined (Fig. 3). It showed a 30-times lower EC 50value of 0.391 nM at the CB 2receptor than at" 5681 5905 W2404390137.pdf 8 19 paratext 0.9675123 Forensic Toxicol (2016) 34:329–343 337 5905 5943 W2404390137.pdf 8 20 separator 0.7838415 ¶ 5943 5945 W2404390137.pdf 8 21 paratext 0.97920245 123 5945 5949 W2404390137.pdf 8 0 title 0.6490411 AdvancesinMeteorology 7Ozone concentration (ppb) 0 48 W2022920110.pdf 6 1 separator 0.97790086 ¶ 48 50 W2022920110.pdf 6 2 table 0.9894242 "12 24 36 48 60 72 84 96 108 120020406080100120140 Date (hour)0 Qiaotou (B-1) Nanzi (B-2) Renwu (B-3)Fengshan (B-4) Dailao (B-5) Fuxing (B-6)10" 50 205 W2022920110.pdf 6 3 separator 0.9855001 ¶ 205 207 W2022920110.pdf 6 4 caption 0.99504316 "Figure 6: Observed O3concentrations and wind field between group(Bgroup)ambientairqualitymonitoringstationsduringJune28andJuly2,2013." 207 343 W2022920110.pdf 6 5 separator 0.97597027 ¶ 343 345 W2022920110.pdf 6 6 text 0.99246657 "peaked above 100ppb in the afternoon of June 30, exceed- ing the concentrations throughout the rest of Kaohsiung(Figure9(c) ). When the WPSH moved gradually east after July1,diffusionandtransportationofairpollutantsimproved,causingtheO 3concentrationtoslowlydecreaseto35 ∼40ppb (Figure9(d) )afterJ uly2.TheO3concentrationdecreasedby more than 50% once the WPSH shifted away from Taiwan(Figure9(e) )." 345 755 W2022920110.pdf 6 7 separator 0.98034286 ¶ 755 757 W2022920110.pdf 6 8 text 0.9994022 "I na d d i t i o n ,i tw a sf o u n dt h a tac l o s e ds u b t r o p i c a lh i g h formedbelowthegeopotentialheight(gpm)of5,880mintheatmosphere above the western Pacific Ocean (Figures 8(a)∼ 8(e)).SoutheasterlywindsformedwhenthesubtropicalhighedgeformedtothewestofTaiwanneartheEastSea(June29)." 757 1057 W2022920110.pdf 6 9 separator 0.96113276 ¶ 1057 1059 W2022920110.pdf 6 10 text 0.9996737 "By contrast, when the edge of the subtropical high wass i t u a t e di nt h ea t m o s p h e r ea b o v eT a i w a n ,s o u t h e r l yw i n d sblew (June 30). Because of warming caused by a descendingdraft, the weather was dry, humidity was low, and the baricgradient was so weak with nearly no wind. The temperature wassufficientlyhightocausesubsidenceinversion[ 28].After June30,theWPSHbegantoleaveTaiwan,shiftingnortheast.Only the east side of Kaohsiung remained affected by thesubtropicalhigh,andtherefore,theweatherconditionsintheeast were stable and dry with low humidity and weak wind(Figures6to8)." 1059 1670 W2022920110.pdf 6 11 separator 0.9786867 ¶ 1670 1672 W2022920110.pdf 6 12 text 0.9995279 "The aforementioned meteorological phenomena verify that the presence of the WPSH substantially influences thedilution and transportation of air pollutants in ambient air,particularly in the locations affected by the leeward side andthe WPSH. The simulated results from gpm below 500hpa(Figures8(a)∼8(e)) and concentration distributions of O 3 (Figures9(a)∼9(e))indicatedthatthepeakO3concentration occurred in the western coastal area of Kaohsiung in theafternoon of June 30 (see details in Table 3), during which time a southeasterly blew toward Eastern Taiwan, resultingin a subsidence temperature inversion in western Taiwan(see blue color pattern in Figures 9(b)∼9(c)). Thus, poor air qualitywasfound." 1672 2389 W2022920110.pdf 6 13 separator 0.9972538 ¶ 2389 2391 W2022920110.pdf 6 14 title 0.99293023 "3.3.SpatialDistributionofO 3intheAmbientAirWhileWPSH" 2391 2446 W2022920110.pdf 6 15 separator 0.9932467 ¶ 2446 2448 W2022920110.pdf 6 16 text 0.99958014 "Moving.ThepresenceofWPSHistypicallyaccompaniedby weather conditions for the accumulation of air pollutants,such as, stream downdraught, temperature inversion, rarecloud coverage, short-wave radiation, low relative humidity,a n ds l o ww i n ds p e e d .S o m eo ft h e mw e r es h o w ni nt h eafternoon of June 30, 2013. WPSH was more likely toaccumulate O 3. In this investigated case, peak O3concen- trations were observed at every monitoring station exceptthe M-1 station where they occurred in the afternoon ofJune 30. Therefore, the 24h O 3concentration monitoring data collected throughout the day were compared using acorrelation coefficient comparison (see Table 4). During the period for the O 3concentration reaching peak high, the correlation coefficients between O-1 and the other stationswereusuallyhigherthan0.6,suggestingbeinghighlyrelated.Forexample,atO-2onJune28,thehighestO 3concentration was 102ppb. Because the wind blew from the west andnorthwest, the highest O 3concentrations at O-2 and B-6, which were located downwind, were observed an hour later." 2448 3546 W2022920110.pdf 6 17 separator 0.9108782 ¶ 3546 3548 W2022920110.pdf 6 18 text 0.9996659 "Ontheotherhand,forstationO-5,relativelypoorcorrection was observed, which may result from the brink of a riverto the sea. Sea breeze effect is more obvious than otherlocations." 3548 3727 W2022920110.pdf 6 19 separator 0.9661187 ¶ 3727 3729 W2022920110.pdf 6 20 text 0.999647 "RegardingtheM-1monitoringstationinaruralarea,after analysis,highcorrelationcoefficientsremainedamongurbanmonitoring stations ( Table 4). However, most correlation coefficients of O-5 and some stations were below 60%. M-2exhibitedthelowestcoefficientof0.48." 3729 3990 W2022920110.pdf 6 21 separator 0.97031224 ¶ 3990 3992 W2022920110.pdf 6 22 text 0.99915683 "The sea breeze affected the wind speed (3m/s) at the O - 5s t a t i o n ,a n das w i ftw i n db l e wf r o mt h es o u t ha n dsouthwest preventing O 3from accumulating. However, data showingO3concentrationsexceeding100ppbateachstation" 3992 4234 W2022920110.pdf 6 0 paratext 0.99053425 Page 18/20 0 10 W4239922832.pdf 17 1 separator 0.99535584 ¶ 10 12 W4239922832.pdf 17 2 caption 0.916938 Figure 5 12 21 W4239922832.pdf 17 3 separator 0.98990583 ¶ 21 23 W4239922832.pdf 17 4 text 0.94333035 SOX2 is positively associated with the induction of CIgG, and CIgG knockdown reduces MAPK/ERK and ¶ 23 123 W4239922832.pdf 17 5 caption 0.8250695 123 124 W4239922832.pdf 17 6 text 0.50740385 AKT 124 127 W4239922832.pdf 17 7 caption 0.9406199 "activity in PCa cells and inhibits EMT. Spearman correlation analysis of SOX2 with AR in clinical tissue samples from TCGA prostate cancer datasets(A-B). Signi" 127 289 W4239922832.pdf 17 0 paratext 0.9307084 "23 International Journal of Entrepreneurship and Small Business, 29(4), 602. https://doi.org/10.1504/IJESB.2016.079965" 0 125 W4285266156.pdf 22 1 separator 0.9898597 ¶ 126 128 W4285266156.pdf 22 2 bibliography 0.99446934 "Dana, L.-P., Grimwood, S., & William, G. (2009a). Export Incentives and International Entrepreneurship in New Zealand Firms. Journal of International Business and Entrepreneurship Development, 4(1/2), 1–21. https://doi.org/10.5367/000000006775870497" 128 387 W4285266156.pdf 22 3 separator 0.941315 ¶ 388 390 W4285266156.pdf 22 4 bibliography 0.99454457 "Dana, L.-P., Hamilton, R. T., & Wick, K. (2009b). Deciding to export: An exploratory study of Singaporean entrepreneurs. Journal of International Entrepreneurship, 7(2), 79–87. https://doi.org/10.1007/s10843-008-0032-8" 390 615 W4285266156.pdf 22 5 separator 0.95938677 ¶ 616 618 W4285266156.pdf 22 6 bibliography 0.9904761 "Dana, L.-P., & Wright, R. W. (2009). International entrepreneurship: research priorities for the future. International Journal of Globalisation and Small Business, 3(1), 90–134. https://doi.org/10.1504/IJGSB.2009.021572" 618 844 W4285266156.pdf 22 7 separator 0.9817457 ¶ 845 847 W4285266156.pdf 22 8 bibliography 0.9978073 "Devine, R. A., Molina‐Sieiro, G., Holmes Jr., R. M., & Terjesen, S. A. (2019). Female‐Led high‐growth: Examining the role of human and financial resource management. Journal of Small Business Management , 57(1), 81-109." 847 1073 W4285266156.pdf 22 9 separator 0.9633008 ¶ 1074 1076 W4285266156.pdf 22 10 bibliography 0.99789494 "Dinesh, K. K., & Sushil. (2019). Strategic innovation factors in startups: results of a cross- case analysis of Indian startups. 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McGraw-Hill Education (UK)." 1707 1826 W4285266156.pdf 22 17 separator 0.96491945 ¶ 1827 1829 W4285266156.pdf 22 18 bibliography 0.9979881 "Hajiagha, S. H. R., Mahdiraji, H. A., & Hashemi, S. S. (2013). Multi‐objective linear programming with interval coefficients. Kybernetes." 1829 1970 W4285266156.pdf 22 19 separator 0.91623855 ¶ 1972 1974 W4285266156.pdf 22 20 bibliography 0.99805856 "Hajiagha, S. H. R., Hashemi, S. S., Mahdiraji, H. A., & Azaddel, J. (2015). Multi-period data envelopment analysis based on Chebyshev inequality bounds. Expert Systems with Applications , 42(21), 7759-7767." 1974 2187 W4285266156.pdf 22 21 separator 0.96363866 ¶ 2189 2191 W4285266156.pdf 22 22 bibliography 0.99803394 "Hajiagha, S. H. R., Mahdiraji, H. A., Tavana, M., & Hashemi, S. S. (2018). A novel common set of weights method for multi-period efficiency measurement using mean-variance criteria. Measurement , 129, 569-581" 2191 2406 W4285266156.pdf 22 23 separator 0.98337793 ¶ 2407 2409 W4285266156.pdf 22 24 bibliography 0.9978804 "Harel, G. H., & Tzafrir, S. S. (1999). The effect of human resource management practices on the perceptions of organizational and market performance of the firm. Human Resource Management: Published in Cooperation with the School of Business Administration, The University of Michigan and in alliance with the Society of Human Resources Management , 38(3), 185-199." 2409 2787 W4285266156.pdf 22 25 separator 0.98075515 ¶ 2788 2790 W4285266156.pdf 22 26 bibliography 0.9977655 "Hassan, S. (2016). Impact of HRM practices on employee’s performance. International Journal of Academic Research in Accounting, Finance and Management Sciences, 6(1), 15-22." 2790 2970 W4285266156.pdf 22 27 separator 0.97860616 ¶ 2971 2973 W4285266156.pdf 22 28 bibliography 0.9980883 "Jack, S., Hyman, J., & Osborne, F. (2006). Small entrepreneurial ventures culture, change and the impact on HRM: A critical review. Human Resource Management Review, 16(4), 456-466." 2973 3161 W4285266156.pdf 22 29 separator 0.98148084 ¶ 3162 3164 W4285266156.pdf 22 30 bibliography 0.9979314 "Jafari-Sadeghi, V., Kimiagari, S., & Biancone, P. P. (2019). Level of education and knowledge, foresight competency and international entrepreneurship: A study of human capital determinants in the European countries. European Business Review, 32(1), 46-68. https://doi.org/10.1108/EBR-05-2018-0098" 3164 3471 W4285266156.pdf 22 0 text 0.94507176 "134(making and matching ) stále dokonalejšímu obrazu skutečnosti, který sloužil jako norma pro posouzení, zda je objekt uměleckým dílem.33" 0 141 W4245246133.pdf 7 1 separator 0.98623896 ¶ 142 144 W4245246133.pdf 7 2 text 0.99945724 "Zlom v tomto vývoji nastal podle Danta v pozdním devatenáctém století se vznikem fotografie a rané kinematografie, která završila úsilí statického média tím, že umožnila vyjádřit (a nikoli pouze naznačit) pohyb. Kinematografická technologie vyřešila staleté snahy o co nejvěrnější nápodobu vnější reality a posunula umělecký zájem k realitě vnitř - ní, ležící za hranicemi smyslového vnímání. Touto tendencí pokračoval i trend rozvíjející se umělecké teorie, která popisovala jevy, jež nebylo možné interpretovat v pojmech vidi - telného světa. Takové směřování dovedly podle Danta do krajnosti manifesty moderního umění, které vetkly umělecké praxi filozofický rozměr; přijmout něco jako umění od té doby obnášelo pochopit filozofii, která ho obhajovala." 144 922 W4245246133.pdf 7 3 separator 0.9844049 ¶ 923 925 W4245246133.pdf 7 4 text 0.99889386 "Protože naslouchalo umění dvacátého století stále více filozofickému pojetí pravdy, na jehož základě pokládalo každé hnutí právě svoji tvorbu jako „ akt obnovy, odhalení či je - vení pravdy, která byla ztracená nebo brána jen nejasně na vědomí “, závisela jeho existence stále více na umělecké teorii.34 Ta přestávala fungovat jako vnější součást světa, které se umění jako objektu svého zájmu snažilo porozumět, a stala se vnitřní součástí díla samot - ného. Pakliže chtělo umělecké dílo pochopit svůj obsah, muselo nyní pochopit především sebe sama. Snaha po zvnitřnění vlastní teorie a myšlenky o sobě samém vede podle Danta umění do stavu, ve kterém dosahuje „ nulové existence “ zatímco jeho teorie se přibližuje nekonečnu takovým způsobem, že „ vlastně všechno, co nakonec zbývá, je teorie “.35" 925 1748 W4245246133.pdf 7 5 separator 0.990958 ¶ 1748 1750 W4245246133.pdf 7 6 text 0.9994227 "Danto se v této souvislosti odvolává na teorii Clementa Greenberga, který hovoří o moderním umění jako reflexivním obratu k sobě samému, jenž odhaluje vnitřní sou - vislost mezi uměním a filozofií. Moderní umění se dle něj vysvléklo ze svých mimetic - kých kvalit, které v platónském duchu deklasují umění v pouhou náhražku reality, a pro - střednictvím vědomí sebe sama podniklo kvazikantovské pátrání po vlastních základech." 1750 2186 W4245246133.pdf 7 7 separator 0.9862528 ¶ 2187 2189 W4245246133.pdf 7 8 text 0.99945503 "S příchodem modernismu se stává umění subjektem svého vlastního zájmu a prostřed - nictvím vlastního působení se snaží určit účinky, které jsou pro jednotlivé umělecké dis - ciplíny výlučné. Malířství, kterému Greenberg věnuje nejvíce pozornosti, se kupříkladu emancipuje od aspektů, které náleží primárně jiným disciplínám, jako trojrozměrnost sochařského média či iluze podmalby a stínování. Sám Greenberg ztotožňuje esenci mal - by s plochostí, pomocí které dospěla k základním otázkám kompozice a monochromu." 2189 2714 W4245246133.pdf 7 9 separator 0.8796203 ¶ 2715 2717 W4245246133.pdf 7 10 text 0.9986581 "Tvrdí, že se tím malířství stalo nejen filozofickým, ale také skutečně historickým, neboť skrze popírání aspektů vlastní tradice si mohlo začít uvědomovat i své dějiny.36" 2717 2891 W4245246133.pdf 7 11 separator 0.97862524 ¶ 2891 2893 W4245246133.pdf 7 12 text 0.9995124 "Nicméně aby mohlo umění dosáhnout svého vrcholu, tj. své filozofie, musí dle Dan - ta položit otázku po své podstatě ve správném filozofickém znění. Přestože manifesty moderního umění tyto snahy reflektují, v odpovědi na vlastní podstatu selhávají, neboť zůstávají v zajetí hranic daného manifestu. Tvrdí, že pouze jejich umění je to správné, „ že" 2893 3249 W4245246133.pdf 7 13 separator 0.96548486 ¶ 3250 3252 W4245246133.pdf 7 14 bibliography 0.99027836 "33 Termín pochází z Gombrichovy studie Umění a iluze , která vznikla jako série přednášek přednese - ných roku 1956 v Národní galerii ve Washingtonu pod pracovním názvem The Visible World and the Language of Art . Viz Ernst Gombrich, Umění a iluze , Praha 1985. – Veronika Kopecky, Letters to and from Ernst Gombrich regarding Art and Illusion , including some comments on his notion of „schema and correction“, Journal of Art Historiography , 2010, č. 3, nepag." 3252 3727 W4245246133.pdf 7 15 separator 0.8393338 ¶ 3728 3730 W4245246133.pdf 7 16 bibliography 0.99689555 34 Danto (pozn. 3), s. 28. 3730 3757 W4245246133.pdf 7 17 separator 0.899479 ¶ 3757 3759 W4245246133.pdf 7 18 bibliography 0.9973027 35 Danto, Konec umění (pozn. 6), s. 16. 3759 3799 W4245246133.pdf 7 19 separator 0.96053445 ¶ 3799 3801 W4245246133.pdf 7 20 bibliography 0.99620295 "36 Clement Greenberg, Modernistická malba, in: Tomáš Pospiszyl (ed.), Před obrazem , Praha 1998, s. 36." 3801 3908 W4245246133.pdf 7 0 title 0.94665384 CORRE CTION 0 11 W2902680375.pdf 0 1 separator 0.99575204 ¶ 11 13 W2902680375.pdf 0 2 title 0.8649538 "Correction: Theinfluences oftheM2R-GIRK4- RGS6 dependent parasympathetic pathway onelectrophysiol ogical properties ofthe mouse heart" 13 153 W2902680375.pdf 0 3 separator 0.9955777 ¶ 153 155 W2902680375.pdf 0 4 bibliography 0.99188614 "Kanchan Kulkarni, Xueyi Xie, Ezequiel Marron Fernandez deVelasco, Allison Anderson, Kirill A.Martemyanov, Kevin Wickman, Elena G.Tolkacheva" 155 297 W2902680375.pdf 0 5 separator 0.95694804 ¶ 297 299 W2902680375.pdf 0 6 bibliography 0.673779 The third author's lastname appears 299 335 W2902680375.pdf 0 7 text 0.6682513 incorrectly 335 347 W2902680375.pdf 0 8 bibliography 0.46692744 347 348 W2902680375.pdf 0 9 text 0.46162918 inthe 348 353 W2902680375.pdf 0 10 bibliography 0.5617186 citation. 353 362 W2902680375.pdf 0 11 text 0.55493784 The correct 362 374 W2902680375.pdf 0 12 bibliography 0.5469693 citation is: 374 387 W2902680375.pdf 0 13 separator 0.98094547 ¶ 387 389 W2902680375.pdf 0 14 bibliography 0.99605215 "Kulkarni K,XieX,Marron Fernandez deVelasco E,Anderson A,Martemyanov KA, Wickman K,etal.(2018) The influences oftheM2R-GIRK4-RGS6 dependent parasympa- thetic pathway onelectrophysiological properties ofthemouse heart. PLoS ONE 13(4): e0193798. https://doi.org/10.1 371/journal.pone.0193798" 389 684 W2902680375.pdf 0 15 separator 0.9844196 ¶ 684 686 W2902680375.pdf 0 16 paratext 0.77894694 Reference 686 696 W2902680375.pdf 0 17 separator 0.9794868 ¶ 696 698 W2902680375.pdf 0 18 bibliography 0.98430526 "1. Kulkarni K,XieX,Fernandez deVelasco EM, Anderson A,Martemy anov KA,Wickma nK,etal.(2018) The influence softheM2R-GIRK4- RGS6 depende ntparasympath eticpathway onelectrophy siological properties ofthemouse heart. PLoS ONE 13(4): e0193798. https://do i.org/10.1371 /journal.pon e. 0193798 PMID: 29668674" 698 1009 W2902680375.pdf 0 19 separator 0.7735565 ¶ 1009 1011 W2902680375.pdf 0 20 paratext 0.9406915 "PLOS ONE |https://doi.or g/10.137 1/journal.po ne.02005 53 July 6,2018 1/1a1111111111 " 1011 1100 W2902680375.pdf 0 21 math 0.31309584 a11 1100 1103 W2902680375.pdf 0 22 paratext 0.27843067 11111111 1103 1111 W2902680375.pdf 0 23 math 0.31819493 ¶ 1111 1113 W2902680375.pdf 0 24 table 0.3168848 1113 1114 W2902680375.pdf 0 25 math 0.36668062 a11 1114 1117 W2902680375.pdf 0 26 table 0.3231302 11111111 1117 1125 W2902680375.pdf 0 27 math 0.35733014 ¶ a1111111111 ¶ 1125 1141 W2902680375.pdf 0 28 paratext 0.44744802 a1111111111 1141 1153 W2902680375.pdf 0 29 separator 0.83346945 ¶ 1153 1155 W2902680375.pdf 0 30 paratext 0.8926024 OPEN ACCESS 1155 1167 W2902680375.pdf 0 31 separator 0.9864002 ¶ 1167 1169 W2902680375.pdf 0 32 bibliography 0.96887743 "Citation: Kulkarni K,XieX,Marron Fernandez de Velasco E,Anderso nA,Martemyanov KA, Wickman K,etal.(2018) Correction: The influences oftheM2R-GIRK4- RGS6 dependent parasympathe ticpathway onelectrop hysiological properties ofthemouse heart. PLoS ONE13(7): e0200553. https://d oi.org/10.1371/j ournal. ¶" 1169 1483 W2902680375.pdf 0 33 paratext 0.69605625 pone.020055 3 1483 1497 W2902680375.pdf 0 34 separator 0.81944156 ¶ 1497 1499 W2902680375.pdf 0 35 paratext 0.9740392 Published: July6,2018 1499 1521 W2902680375.pdf 0 36 separator 0.57512856 ¶ 1521 1523 W2902680375.pdf 0 37 paratext 0.9432458 "Copyright: ©2018 Kulkarni etal.Thisisanopen access article distributed under theterms ofthe Creative Commons Attribution License, which permits unrestricte duse,distribu tion,and reproduction inanymedium, provided theoriginal author andsource arecredited." 1523 1789 W2902680375.pdf 0 0 paratext 0.97703177 79Bruno Camporeze, et al. Journal of Health Sciences 2017;7(2):68-79 http://www.jhsci.ba 0 90 W2647797892.pdf 11 1 separator 0.5527245 ¶ 90 92 W2647797892.pdf 11 2 paratext 0.9168375 https://doi.org/10.1159/000098630. 93 128 W2647797892.pdf 11 3 separator 0.9924713 ¶ 128 130 W2647797892.pdf 11 4 bibliography 0.9971633 "68. Santos CA, Svartman C, Alirio J, Lianza S. Espasticidade: Procedimentos Cirurgicos Orthopedicos. São Paulo: Associacao Brasileira de Medicina Fisica e Reabilitacao; 2006." 130 311 W2647797892.pdf 11 5 separator 0.9722787 ¶ 311 313 W2647797892.pdf 11 6 bibliography 0.9935979 "69. Franzini A, Ferroli P, Marras C, Broggi G. Huge epidural hematoma after surgery for spinal cord stimulation. Acta Neurochir (Wien) 2005;147:565-7. https://doi.org/10.1007/s00701-004-0470-6." 313 513 W2647797892.pdf 11 7 separator 0.97421694 ¶ 513 515 W2647797892.pdf 11 8 bibliography 0.99205506 "70. Hollingworth W, Turner JA, Welton NJ, Comstock BA, Deyo RA. Costs and cost-effectiveness of spinal cord stimulation (SCS) for failed back surgery syndrome an observational study in a workers’ compensation population. SPINE 2011;36(24):2076-83. https://doi.org/10.1097/BRS.0b013e31822a867c." 515 818 W2647797892.pdf 11 9 separator 0.97812057 ¶ 818 820 W2647797892.pdf 11 10 bibliography 0.9923458 "71. Dario A, Fortini G, Bertollo D, Bacuzzi A, Grizzetti C, Cuffari S. Treatment of failed back surgery syndrome. Neuromodulation 2001;4:105-10. https://doi.org/10.1046/j.1525-1403.2001.00105.x." 820 1024 W2647797892.pdf 11 11 separator 0.9758827 ¶ 1024 1026 W2647797892.pdf 11 12 bibliography 0.9972789 "72. Ohnmeiss DD, Rashbaum RF, Bogdanffy GM. Prospective outcome eval - uation of spinal cord stimulation in patients with intrac table leg pain. Spine 1996;21(11):1344-51." 1026 1204 W2647797892.pdf 11 13 separator 0.7107205 ¶ 1204 1206 W2647797892.pdf 11 14 bibliography 0.9913657 https://doi.org/10.1097/00007632-199606010-00013 . 1207 1258 W2647797892.pdf 11 0 paratext 0.533558 2 0 1 W4386319945.pdf 1 1 title 0.9057317 Editorial 1 11 W4386319945.pdf 1 2 separator 0.9948245 ¶ 11 13 W4386319945.pdf 1 3 text 0.9912472 "War and more recently in the development of the Treaty on the Prohibition of Nuclear Weapons. We must take up this challenge again as an urgent priority, working with renewed energy to reduce the risks of nuclear war and to eliminate nuclear weapons." 13 276 W4386319945.pdf 1 4 separator 0.9961295 ¶ 276 278 W4386319945.pdf 1 5 title 0.97399664 Provenance and peer review 278 305 W4386319945.pdf 1 6 separator 0.9848837 ¶ 305 307 W4386319945.pdf 1 7 text 0.97201276 Commissioned for the BMJ; not externally peer reviewed. 307 363 W4386319945.pdf 1 8 separator 0.99470705 ¶ 363 365 W4386319945.pdf 1 9 title 0.97274476 Conflict of interest 365 386 W4386319945.pdf 1 10 separator 0.97982347 ¶ 386 388 W4386319945.pdf 1 11 text 0.99021393 "The authors have warranted to BMJ that they have read and understood the BMJ policy on declaration of interests and have no relevant interests to declare." 388 549 W4386319945.pdf 1 12 separator 0.9960692 ¶ 549 551 W4386319945.pdf 1 13 title 0.9049848 References 551 562 W4386319945.pdf 1 14 separator 0.9937972 ¶ 562 564 W4386319945.pdf 1 15 bibliography 0.9798048 "1.Science and Security Board, Bulletin of the Atomic Scientists. 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Cryst Eng Comm, 2012, 14: 8424-8431." 3833 4094 W2469120423.pdf 11 33 separator 0.96934795 ¶ 4094 4096 W2469120423.pdf 11 34 paratext 0.9389704 Copyright© 2016 4096 4113 W2469120423.pdf 11 35 bibliography 0.91118515 "Kevin Mauge-Lewis, Brittney Gordon, Fareeha Syed, Saarah Syed, Enock Bonyi, Muzaffer Mohammed, Eric A. Toth, Dereje Seifu, and Kadir Aslan" 4113 4254 W2469120423.pdf 11 36 paratext 0.9153672 . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 4254 4491 W2469120423.pdf 11 0 paratext 0.95115566 POLISH MARITIME RESEARCH , No 3/2023175 0 39 W4387570022.pdf 1 1 title 0.5002204 all 39 42 W4387570022.pdf 1 2 text 0.99795914 "continents. By 2000, more than 3,000 offshore oil and gas fields had been discovered [7]. Products are delivered to land using special product pipelines that are laid on the seabed on special supports or buried in the ground [8]. They are in difficult operating conditions, and in addition to the working pressure of the transported product, they are also loaded with external hydrostatic water pressure. Pipelines can also be affected by waves and currents. They must be insulated to protect against corrosion and lined to protect the coating from mechanical damage [9]. Unlike deep-water drilling, offshore mining takes place at a depth of 100...200 meters. However, the work is complicated due to water surface disturbance, rock washout, and its release into the habitat of marine life, which is a threat to the environment [10]. Most underwater vehicles operating at these depths have a limited carrying capacity, which can be increased by equipping them with buoyancy modules (Fig. 1), which are installed externally in a space free of equipment and supporting structures." 42 1168 W4387570022.pdf 1 3 separator 0.9963312 ¶ 1169 1171 W4387570022.pdf 1 4 caption 0.98939306 Fig. 1. Buoyancy modulus [10] 1171 1201 W4387570022.pdf 1 5 separator 0.946072 ¶ 1201 1203 W4387570022.pdf 1 6 text 0.99306595 "They can have a variety of configurations and consist of separate blocks that are not identical in size and shape [11]. They are an integral part of the combined buoyancy systems that are placed in volumes free of load-bearing structures and are subject to hydrostatic pressure during operation." 1203 1511 W4387570022.pdf 1 7 separator 0.70275676 ¶ 1511 1513 W4387570022.pdf 1 8 text 0.99962646 "Problematic issues in their design and operation are the combination of strength characteristics of structures with reduced weight and dimensions and functional capabilities to operate under extreme conditions of wave, hydrostatic, and acoustic loads. Solutions include the development and use of highly specialised and multifunctional composite materials." 1513 1885 W4387570022.pdf 1 9 separator 0.8332057 ¶ 1886 1888 W4387570022.pdf 1 10 text 0.9997623 "Due to a set of valuable physical and mechanical properties, the use of inorganic glass shells, glass, and alumina ceramics is considered universal in deep-water technologies. Theoretical and experimental studies of their strength have shown that, along with lightness and strength, shell structures made of these materials are non-magnetic, radiotransparent, and chemically resistant." 1888 2289 W4387570022.pdf 1 11 separator 0.8907968 ¶ 2289 2291 W4387570022.pdf 1 12 text 0.9997099 "Buoyancy materials are subject to the requirements of low density, optimal buoyancy, ability to withstand hydrostatic loads, high specific strength, corrosion and chemical resistance, and resistance to atmospheric and bacterial action." 2291 2536 W4387570022.pdf 1 13 separator 0.85119736 ¶ 2537 2539 W4387570022.pdf 1 14 text 0.999737 "PVC is used for small depths [12]. Also, polyurethane foams will meet these requirements. Each kilogram of polyurethane foam provides a lifting force of approximately 300 N (density as low as 100 kg/m3), so its use is effective in raising sunken vessels, removing them from reefs, shoals, and underwater pipeline equipment. Polyurethane foams are also used to make life-saving equipment such as rafts, belts, bibs, lapel pins, and dinghies. They are used as coatings on the sides of heavy ships and on the floors and ceilings of shipboard accommodations [13]. However, their low strength characteristics do not allow them to be used in technologies for manufacturing additional buoyancy blocks for underwater exploration and research vehicles. The maximum immersion depth of polyurethane foam is 350 meters (density 0.4 kg/m3). In addition, they are flammable, toxic, and unable to operate for a long time at temperatures above 60 °C." 2539 3516 W4387570022.pdf 1 15 separator 0.98333114 ¶ 3516 3518 W4387570022.pdf 1 16 text 0.99975866 "Syntactic foams are considered to be more competitive composite materials. They are synthesised by filling a polymer matrix with glass, ceramic, and carbon microspheres. The existing experience in producing composite materials and coatings based on non-metallic microspheres is based on low-temperature technologies for the preparation of colloidal solutions. Phenolic, polyester, polyamide, and, most often, epoxy matrices are used for the manufacture of composites. They ensure homogeneity of composition, a certain density, and increased adhesion strength. Glass inclusions are evenly distributed in the polymer matrix (Fig. 2a). The use of this material as part of the buoyancy material provides an apparent density in the range of 450...700 kg/m3 with a possible operating depth to 12,000 m [14]. An important disadvantage of syntactic foams is the impossibility of their long-term operation at temperatures above 110 to 130 °C due to the presence of a polymeric thermosetting binder." 3518 4553 W4387570022.pdf 1 17 separator 0.98312515 ¶ 4553 4555 W4387570022.pdf 1 18 text 0.9997427 "The choice of materials is an important and difficult stage in solving design problems. Most polymer compositions are characterised by increased flammability and toxicity, and they lose their thermal insulation properties with increasing temperature and water absorption. Alternative buoyancy composite materials that combine high hydrostatic strength with thermal insulation capacity are foam glasses with a density of 300...700 kg/m3 [15]. The technology for their production is based on the sintering of glass powders with a dispersion of 20...150 μm in a particular sodium silicate composition, with a gas-forming agent (Fig. 2b). As a result, a porous structure is formed, making this material indispensable for use in combined buoyancy units of underwater vehicles with a submergence depth of up to 2000 m." 4555 5404 W4387570022.pdf 1 19 separator 0.9842243 ¶ 5404 5406 W4387570022.pdf 1 20 text 0.9997476 "Thus, the analysis of the problems of using modern composite materials in the technologies of designing and manufacturing underwater technical means has shown the prospects of introducing materials with a cellular structure that provides a set of valuable operational properties. The choice of raw materials for their creation is based on the principles of forming cells with a certain geometry. For this purpose, dispersed substances such as glass powders or hollow microspheres are suitable. Reducing the density of the compositions will be facilitated by the choice of high- temperature technologies, such as sintering, which will exclude the use of polymeric binders. However, the influence of technological parameters, in particular temperature and pressure, on the processes of structure formation during the sintering of microspheres without additional impurities remains insufficient." 5406 6337 W4387570022.pdf 1 21 separator 0.9968138 ¶ 6337 6339 W4387570022.pdf 1 0 paratext 0.95857096 "IAJPS 2018, 05 (08), 8002-8006 Amna Ashraf et al ISSN 2349-7750 ¶ w w w . i a j p s . c o m Page 8004" 0 161 W4289671268.pdf 2 1 title 0.796159 The data of research was under statistical analysis . 162 216 W4289671268.pdf 2 2 separator 0.940331 ¶ 217 219 W4289671268.pdf 2 3 text 0.99967843 "The data w as entered in computer & analysed by using the methods of IBM, SPSS software having a version of (20.0) . By using the Chi-square test, the comparison among different groups with respect to categorical was carried out. The time when more than twenty percent of cells were hoped to be counted less than five, the correction for chi-square was performed by the method of Monte Carlo correction or fisher ’s Exact test. In case the data was distributed in an abnormal manner, the tests used for normally distributed data were nonparametric tests. The contrastive study among 2 studied groups was performed using independent t-test but in case of data distributed abnormally, the comparison was carried out using Mann Whitney test. The importance of obtained outcomes was examined at the level of five percent." 219 1085 W4289671268.pdf 2 4 separator 0.99146223 ¶ ¶ 1087 1093 W4289671268.pdf 2 5 title 0.95056945 RESULTS: 1093 1102 W4289671268.pdf 2 6 separator 0.986943 ¶ 1104 1106 W4289671268.pdf 2 7 text 0.9995124 "The following was the result of all cases: 79 percent were HPV -ve & 21 percent were HPV +ve , 34 percent were -ve for intraepithelial lesions i.e. 30 percent normal & 66 percent were +ve for intraepithelial lesions & 37 percent ASCUS. And 18 percent LSIL and 11 percent of HSIL. One percent inflammatory atypia and three percent squamous metaplasia." 1106 1478 W4289671268.pdf 2 8 separator 0.84514016 ¶ ¶ 1480 1486 W4289671268.pdf 2 9 text 0.9977837 "Underlying relationship among abnormal cytology results and HPV DNA results was shown in the table no.1. Moreover, it demonstrated that sixty-six cases had intraepithelial lesions of cervix and eleven cases had HSIL. From these 11 cases, three were negative for HPV & eight were positive for HPV. Eighteen cases had LSIL & from these eighteen cases , seventeen were negative & one was found to be positive. For HPV category, thirty-seven cases had ASCUS from which thirty were negative & six were found positive for HPV. A clear +ve link was found between HPV DNA positivity & HSIL. Size and configuration, nuclei are round with minimal irregular outlines and size 2-3 times of normal intermediate cell or twice the squamous metaplastic cell. ¶ All the cases of LSIL and ASCUS have been re- smeared after a time period of three to six months." 1486 2378 W4289671268.pdf 2 10 separator 0.6906606 ¶ 2379 2381 W4289671268.pdf 2 11 text 0.99859256 "Moreover, there was a regression of abnormality found in thirty-four cases which was 91.9 percent & thirteen cases which was 72.2 percent. And there was found a persistence of abnormality in three cases i.e. 8.1 perce nt of ASCUS & five cases i.e. 27.8 percent in the case of LSIL. The colposcopy examinations of all cases along with HSIL i.e. ten out of eleven cases were attended. The +ve HPV which was sixteen out of twenty-one cases were attended and persistent LSIL & ASCUS. The cases along with abnormal cytology were examined through VIA test and colposcopy had abnormal lesions. The biopsies were obtained & ten in sixteen cases of HPV +ve at the percentage of 62.5 have abnormal lesions by colposcopy. The biopsies have been obtained & results were fourteen cases of CIN I & four cases of CIN II as in the table no.2. ¶ The table no. 2 shows that seven in ten HPV positive cases had CIN I & three cases had CIN II. Moreover, six in ten cases with HSIL had CIN I & four cases had CIN II. Three cases of ASCUS had CIN I & five cases of LSIL. ¶ The outcomes of this study showed that HPV DNA testing had sensitivity at 22.73 percent and specificity which was found at 82.35 percent. When compared with Pap test in table no.3, it was found that +ve predictive value i.e. PPV was 67.43 percent & -ve predictive value i.e. NPV at the rate of 35.44 & the accuracy was 43 percent." 2381 3853 W4289671268.pdf 2 12 separator 0.9913051 ¶ ¶ 3855 3861 W4289671268.pdf 2 13 title 0.9824971 Table 1: Relation between HPV DNA results and different types of abnormal cytolog y 3861 3946 W4289671268.pdf 2 14 separator 0.93271655 ¶ 3947 3949 W4289671268.pdf 2 15 table 0.98442817 "HPV 2 p Negative (n = 51) Positive (n = 15) No. % No. % Positive smears 16.229* MCp <0.001* Cases with HSIL 3 5.9 8 53.3 18.791 FEp <0.001* Cases with LSIL 17 33.3 1 6.7 4.156* FEp = 0.051* Cases with ASCUS 31 60.8 6 40.0 2.033 0.154 ¶" 3950 4229 W4289671268.pdf 2 16 separator 0.84881073 ¶ ¶ 4231 4237 W4289671268.pdf 2 0 paratext 0.9825863 Water 2020 ,12, 1340 10 of 21 0 29 W3020846648.pdf 9 1 separator 0.994902 ¶ 29 31 W3020846648.pdf 9 2 text 0.99855953 "Bay ranged from 0.2 to 3.1, with an average of 1.4, and evenness values ranged from 0.2 to 0.4, with an average of 0.3. When Cape Lamb was considered alone, richness ranged from five to 38 with an average of 20.0, evenness ranged from 0.1 to 0.5 with an average of 0.3, and Shannon diversity ranged from 0.5 to 2.7 with an average of 1.9." 31 375 W3020846648.pdf 9 3 separator 0.8873875 ¶ 375 377 W3020846648.pdf 9 4 text 0.99613315 The results of the PCA of the modern samples are summarized in the ordination diagram in 377 466 W3020846648.pdf 9 5 separator 0.77872884 ¶ 466 468 W3020846648.pdf 9 6 text 0.7274246 Figure 6. The first two axes explain 17.2 % of the total 468 524 W3020846648.pdf 9 7 caption 0.6459935 variation in community composition 524 559 W3020846648.pdf 9 8 text 0.8712545 ". The x-axis alone explains 9.8% and is (in general) driven by Cape Lamb pond samples to the right and" 559 663 W3020846648.pdf 9 9 caption 0.5071111 moss 663 668 W3020846648.pdf 9 10 text 0.54811573 668 669 W3020846648.pdf 9 11 caption 0.48112354 ¶ 669 670 W3020846648.pdf 9 12 text 0.557882 samples to 670 681 W3020846648.pdf 9 13 caption 0.5059311 the left 681 690 W3020846648.pdf 9 14 text 0.65177476 . The 690 696 W3020846648.pdf 9 15 caption 0.69750667 y 696 697 W3020846648.pdf 9 16 text 0.7525593 -axis alone explains 7.4% and is primarily driven by the stream and 697 764 W3020846648.pdf 9 17 caption 0.5761145 moss ¶ 764 771 W3020846648.pdf 9 18 text 0.56893814 samples 771 779 W3020846648.pdf 9 19 caption 0.59912884 at 779 782 W3020846648.pdf 9 20 text 0.5586605 the top 782 790 W3020846648.pdf 9 21 caption 0.5088053 of 790 793 W3020846648.pdf 9 22 text 0.5172439 the 793 797 W3020846648.pdf 9 23 caption 0.5755103 plot 797 802 W3020846648.pdf 9 24 text 0.9957861 ". Nitzschia kleinteichiana is strongly associated with lake samples and Fistulifera pelliculosa with streams. Moss samples are influenced by Humidophila vojtajarosikii and Navicula romanedwardii to the left. Navicula gregaria ,N. dobrinatemniskovae , and N. cremeri influence pond samples from Cape Lamb by pulling them to the right of the graph, while Achnanthes muelleri and Luticola vermeulenii pull Devil’s Bay pond samples to the left. When the relationship between diatom community composition and habitat type was tested with PERMANOVA (999 permutations), the di erences between habitat types were significant (pseudo-F =2.917, p<0.001)." 802 1456 W3020846648.pdf 9 25 separator 0.99423945 ¶ 1456 1458 W3020846648.pdf 9 26 paratext 0.98080695 Water 2020 , 12, 1340 10 of 21 1458 1491 W3020846648.pdf 9 27 separator 0.99438465 ¶ 1492 1494 W3020846648.pdf 9 28 text 0.99912816 "belonging to 31 genera were observed in our study , and a complete list of taxa is presented in Table S2. Due to uncertainties in their correct taxonomic identity , several taxa could only be identified to the genus level , and therefore , their distribution could not be designated (Table S2)." 1495 1797 W3020846648.pdf 9 29 separator 0.91211903 ¶ 1798 1800 W3020846648.pdf 9 30 text 0.99647176 "The number of genera recorded per sample ranged from two to 18 , with a median value of nine . The highest number of genera was recorded in a lake sample from Devil’s Bay (Sample L_NE_2 , 18 genera) , and the lowest was found in a stream from the same area (Sample ST_NE_48 , 2 genera). The ten most abundant genera accounted for 89.4 % of all counted valves , and the ten most common taxa from Cape Lamb accounted for 65.3 % of all counted valves from the Cape Lamb dataset . Meanwhile , the ten most common taxa from Devil’s Bay accounted for 68.8 % of all counted valves from the Devil’s Bay dataset." 1800 2424 W3020846648.pdf 9 31 separator 0.9700339 ¶ 2426 2428 W3020846648.pdf 9 32 text 0.9996403 "Overall , the most abundant species was Nitzschia kleinteichiana , representing 20.3 % of all valves counted , followed by Chamaepinnularia krookiiformis (8.9%), Nitzschia paleacea (8.6%), and Nitzschia homburgiensis (7.8%). The most species -rich gen us was Luticola with 23 species , followed by Nitzschia with 11 species. From Cape Lamb , the most abundant taxa were C. krookiiformis (14% of the total relative abundance) , N. kleinteichiana (11%), and N. paleacea (10%), while the Devil’s Bay diatom flora was dominated by N. kleinteichiana (26.7 %), N. homburgiensis (8.8%), N. paleacea (7.5%), and Fistulifera pelliculosa (6.7%, Figure 4)." 2428 3107 W3020846648.pdf 9 33 separator 0.9909124 ¶ ¶ 3108 3114 W3020846648.pdf 9 34 caption 0.99128586 "Figure 4. Dot plot representation of relative abundance counts averaged by sample. Site codes are on the x -axis, and species codes are on the y -axis. The size of a dot is proportional to the relative abundance of a particular species in a given sample. Only diatoms with relative abundances > 4 % are plotted. Pond habitats are indicated by blue circles , moss habitats by green diamonds , seepages by black squares , and streams by red triangles. Symbols for Devil’s Bay are filled , and Cape Lamb sites are represented by outlines only. The k ey for species abbreviations are available in Table S2 and site names in Table S1." 3114 3764 W3020846648.pdf 9 35 separator 0.9928422 ¶ 3766 3768 W3020846648.pdf 9 36 text 0.99860275 "Stream habitats were dominated by N. kleinteichiana (38%), F. pelliculosa (23.8 %), and N. homburgiensis (11.1 %), while moss es were characterized mainly by C. krookiformis (23.7%), N." 3768 3964 W3020846648.pdf 9 37 separator 0.9891684 ¶ 3965 3967 W3020846648.pdf 9 38 caption 0.99090683 "Figure 4. Dot plot representation of relative abundance counts averaged by sample. Site codes are on the x-axis, and species codes are on the y-axis. The size of a dot is proportional to the relative abundance of a particular species in a given sample. Only diatoms with relative abundances >4 % are plotted. Pond habitats are indicated by blue circles, moss habitats by green diamonds, seepages by black squares, and streams by red triangles. Symbols for Devil’s Bay are filled, and Cape Lamb sites are represented by outlines only. The key for species abbreviations are available in Table S2 and site names in Table S1." 3967 4600 W3020846648.pdf 9 0 paratext 0.9848035 Asian Institute of Research Law and Humanities Quarterly Reviews Vol.2, No.1, 2023 0 146 W4323304333.pdf 4 1 separator 0.8785291 ¶ 148 150 W4323304333.pdf 4 2 paratext 0.76896757 47 150 153 W4323304333.pdf 4 3 text 0.84969085 "support, and improve access to resources and support. These efforts are necessary to overcome the challenges and ensure the improvement of English l anguage teaching in Thailand." 153 335 W4323304333.pdf 4 4 separator 0.9824827 ¶ ¶ 337 343 W4323304333.pdf 4 5 title 0.99352217 3.3 Cultural considerations and challenges 343 386 W4323304333.pdf 4 6 separator 0.98027587 ¶ ¶ 388 394 W4323304333.pdf 4 7 text 0.99867404 "Cultural considerations and challenges are critical in teaching and learning English in Thailand. The cultural differences between English and Thai can impact how English language l earning is approached and perceived in the Thai context, as noted by Sirichai and Nakpoo (2023). The Thai language structure and pronunciation can also pose challenges for Thai learners of English. The cultural differences can also influence the expectatio ns and attitudes of learners and teachers toward English language learning, as highlighted by Hill (2022). ¶ Moreover, the role of English in Thai culture and society also poses challenges for English language teaching in Thailand. The use of English in Thai tourism and business, for instance, requires Thai learners to develop their linguistic and intercultural c ompetence, as noted by Kaewsuwan (2022). Furthermore, the perceived status of English in Thai society can influence learners' motivation and attitude toward learning the language. ¶ A more culturally responsive and inclusive approach to English language tea ching is necessary to address these challenges. According to Kirtikara (2021), teachers need to acknowledge the cultural and linguistic variations between Thai and English and implement teaching practices that are relevant and appropriate for Thai learners ." 394 1755 W4323304333.pdf 4 8 separator 0.9149462 ¶ 1756 1758 W4323304333.pdf 4 9 text 0.9961301 "Moreover, promoting intercultural communication and exchange, providing opportunities for cross -cultural experiences, and valuing the role of Thai culture and language in English language learning are essential in developing learners' intercultural compe tence. ¶ In addition, cultural considerations and challenges are critical factors in teaching and learning English in Thailand." 1758 2154 W4323304333.pdf 4 10 separator 0.6426239 ¶ 2155 2157 W4323304333.pdf 4 11 text 0.9891373 "Addressing these challenges through a culturally responsive and inclusive approach to English language teaching is necessary to i mprove the quality and effectiveness of English language learning in Thailand. " 2157 2372 W4323304333.pdf 4 12 separator 0.58823377 ¶ ¶ 2372 2377 W4323304333.pdf 4 13 text 0.9997006 "The work discusses the different factors that impact English language education in Thailand. It highlights the importance of language policy and planning in developing English language education in Thailand. The Thai government has made significant efforts to promote English language learning and integrate it into the national curriculum. However, there are still challenges in implementing language policies, and a more comprehen sive approach is needed. The work also explores the importance of pedagogical principles and practices in ensuring effective English language teaching in Thailand. The communicative language teaching (CLT) approach has gained popularity recently and is see n as effective in enhancing learners' communicative competence. Finally, the study discusses the cultural considerations and challenges that impact English language teaching in Thailand." 2377 3275 W4323304333.pdf 4 14 separator 0.9737866 ¶ 3276 3278 W4323304333.pdf 4 15 text 0.9993489 "Cultural differences between English and Thai can influence how Engli sh language learning is approached and perceived in the Thai context. A more culturally responsive and inclusive approach to English language teaching is necessary. The study cites various studies to support its arguments and provides insights into the ong oing efforts to improve English language education in Thailand." 3278 3678 W4323304333.pdf 4 16 separator 0.92054796 ¶ ¶ 3680 3686 W4323304333.pdf 4 17 title 0.99298394 4. Discussion of policy implications 3686 3723 W4323304333.pdf 4 18 separator 0.9899074 ¶ ¶ 3725 3731 W4323304333.pdf 4 19 text 0.9997359 "The Thai government has prioritized English language learning, implementing several language policies such as making English a medium of instruction in higher education and requiring public sector employees to demonstrate English proficiency. However, ther e are still inconsistencies and fragmentation in policy implementation, with a need for more clarity and coherence, as highlighted by Varavarn and Sawanpanyalert (2020)." 3731 4167 W4323304333.pdf 4 20 separator 0.91952753 ¶ ¶ 4169 4175 W4323304333.pdf 4 21 title 0.99419516 4.1 Current policies and their effectiveness in promoting English language learning 4175 4259 W4323304333.pdf 4 22 separator 0.98925513 ¶ ¶ 4261 4267 W4323304333.pdf 4 23 text 0.9996708 "One policy that has effectively promoted English language learning in Thailand is promoting English as a medium of instruction in higher education. This policy aims to improve Thai universities' international competitiveness and prepare students for the gl obal workforce. According to Varavarn and Sawanpanyalert (2020), this policy has" 4267 4611 W4323304333.pdf 4 0 paratext 0.80806184 Pan et al. Association of sUA and BMD 0 37 W3034709763.pdf 6 1 separator 0.9791569 ¶ 37 39 W3034709763.pdf 6 2 bibliography 0.99748313 "7. ElRidiR,TallimaH.Physiologicalfunctionsandpathogenicpote ntialofuric acid:areview .JAdvRes .(2017)8:487–93.doi:10.1016/j.jare.2017.03.003" 39 182 W3034709763.pdf 6 3 separator 0.96563226 ¶ 182 184 W3034709763.pdf 6 4 bibliography 0.9955005 "8. Kaushal N, Vohora D, Jalali RK, Jha S. Review of the literature exa mining theassociationofserumuricacidwithosteoporosisandmechanis ticinsights intoItseffectonbonemetabolism .EndocrMetabImmunDisordDrugTargets . (2019)19:259–73.doi:10.2174/18715303186661811021151 06" 184 458 W3034709763.pdf 6 5 separator 0.9765507 ¶ 458 460 W3034709763.pdf 6 6 bibliography 0.9973796 "9. Chen F, Wang Y, Guo Y, Wang J, Yang A, Lv Q, et al. Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sec tional study from northeast China . Clin Interventions Aging . (2019) 14:1065– 73.doi:10.2147/CIA.S186500" 460 783 W3034709763.pdf 6 7 separator 0.970049 ¶ 783 785 W3034709763.pdf 6 8 bibliography 0.9976794 "10. Babaei M, Shamsi R, Heidari B, Bijani A, Hosseini SR. Serum uric acid status and its association with bone mineral density in th e elderly people aged 60 years and more . Int J. Endocr Metab . (2019) 17:e80780.doi:10.5812/ijem.80780" 785 1028 W3034709763.pdf 6 9 separator 0.96782434 ¶ 1028 1030 W3034709763.pdf 6 10 bibliography 0.9975726 "11. Kaushal N, Vohora D, Jalali RK, Jha S. Raised serum uric acid is associated with higher bone mineral density in a cross-section al study of a healthy Indian population . Ther Clin Risk Manage . (2018) 14:75– 82.doi:10.2147/TCRM.S147696" 1030 1276 W3034709763.pdf 6 11 separator 0.971537 ¶ 1276 1278 W3034709763.pdf 6 12 bibliography 0.9975155 "12. Hwang J, Hwang JH, Ryu S, Ahn JK. Higher serum uric acid is associa ted with higher lumbar spine bone mineral density in male health-screenin g examinees: a cross-sectional study . J bone Miner Metabol . (2019) 37:142– 51.doi:10.1007/s00774-018-0905-4" 1278 1540 W3034709763.pdf 6 13 separator 0.96979964 ¶ 1540 1542 W3034709763.pdf 6 14 bibliography 0.9976406 "13. Han W, Bai X, Wang N, Han L, Sun X, Chen X. Association between lu mbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectionalstudyofhealthyChinesepopulation .ArchOsteoporosis .(2017) 12:50.doi:10.1007/s11657-017-0345-0" 1542 1801 W3034709763.pdf 6 15 separator 0.96201366 ¶ 1801 1803 W3034709763.pdf 6 16 bibliography 0.9978006 "14. Xiao J, Chen W, Feng X, Liu W, Zhang Z, He L, et al. Serum uric acid is associated with lumbar spine bone mineral density in health y Chinese males older than 50 years . Clin Interventions Aging . (2017) 12:445– 52.doi:10.2147/CIA.S130690" 1803 2052 W3034709763.pdf 6 17 separator 0.9693973 ¶ 2052 2054 W3034709763.pdf 6 18 bibliography 0.99778163 "15. Yan DD, Wang J, Hou XH, Bao YQ, Zhang ZL, Hu C, et al. Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population . Acta pharmacologica Sinica . (2018) 39:626– 32.doi:10.1038/aps.2017.165" 2054 2299 W3034709763.pdf 6 19 separator 0.96297777 ¶ 2299 2301 W3034709763.pdf 6 20 bibliography 0.9978129 "16. Karimi F, Dabbaghmanesh MH, Omrani GR. Association between seru m uric acid and bone health in adolescents . Osteoporosis Int. (2019) 30:2057– 64.doi:10.1007/s00198-019-05072-w" 2301 2486 W3034709763.pdf 6 21 separator 0.95597017 ¶ 2486 2488 W3034709763.pdf 6 22 bibliography 0.99687386 "17. Lee JH. 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(2016) 11:e0154692.doi:10.1371/journal.pone.0154692" 3063 3317 W3034709763.pdf 6 27 separator 0.9693723 ¶ 3317 3319 W3034709763.pdf 6 28 bibliography 0.9979131 "20. Zipf G, Chiappa M, Porter KS, Ostchega Y, Lewis BG, Dostal J. Na tional health and nutrition examination survey: plan and operations, 1999 -2010. VitalHealthStat.1 .(2013)1:1–37." 3319 3506 W3034709763.pdf 6 29 separator 0.9564825 ¶ 3506 3508 W3034709763.pdf 6 30 bibliography 0.9979159 "21. Zhu Y, Pandya BJ, Choi HK. Prevalence of gout and hyperuricemia in the US general population: the national health and nutrition examinatio n survey 2007-2008 .ArthritisRheum .(2011)63:3136–41.doi:10.1002/art.30520" 3508 3730 W3034709763.pdf 6 31 separator 0.96473515 ¶ 3730 3732 W3034709763.pdf 6 32 bibliography 0.9979836 "22. LiuR,HanC,WuD,XiaX,GuJ,GuanH,etal.Prevalenceofhyperuricemi a and gout in mainland China from 2000 to 2014: a systematic review an d meta-analysis .BiomedResInt .(2015)2015:762820.doi:10.1155/2015/762820" 3732 3943 W3034709763.pdf 6 33 separator 0.9703367 ¶ 3943 3945 W3034709763.pdf 6 34 bibliography 0.99795383 "23. LiN,ZhangS,LiW,WangL,LiuH,LiW,etal.Prevalenceofhyperuri cemia and its related risk factors among preschool children from China . Sci Rep. (2017)7:9448.doi:10.1038/s41598-017-10120-824. Shiozawa A, Szabo SM, Bolzani A, Cheung A, Choi HK. Serum uric a cid and the risk of incident and recurrent gout: a systematic review . J Rheumatol . (2017)44:388–96.doi:10.3899/jrheum.160452" 3945 4334 W3034709763.pdf 6 35 separator 0.9797777 ¶ 4334 4336 W3034709763.pdf 6 36 bibliography 0.9978826 "25. LiX,MengX,TimofeevaM,TzoulakiI,TsilidisKK,IoannidisJP ,etal.Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mend elian randomisationstudies .BMJ.(2017)357:j2376.doi:10.1136/bmj.j2376" 4336 4624 W3034709763.pdf 6 37 separator 0.9549968 ¶ 4624 4626 W3034709763.pdf 6 38 bibliography 0.99756 "26. Kubota M. Hyperuricemia in children and adolescents: present knowledge and future directions . J Nutr Metab . (2019) 2019:3480718.doi:10.1155/2019/3480718" 4626 4789 W3034709763.pdf 6 39 separator 0.97321725 ¶ 4789 4791 W3034709763.pdf 6 40 bibliography 0.9976734 "27. Ishii S, Miyao M, Mizuno Y, Tanaka-Ishikawa M, Akishita M , Ouchi Y. Association between serum uric acid and lumbar spine bone mineral de nsity in peri- and postmenopausal Japanese women . Osteoporosis Int. (2014) 25:1099–105.doi:10.1007/s00198-013-2571-7" 4791 5057 W3034709763.pdf 6 41 separator 0.9699334 ¶ 5057 5059 W3034709763.pdf 6 42 bibliography 0.9976708 "28. Ahn SH, Lee SH, Kim BJ, Lim KH, Bae SJ, Kim EH, et al. Higher serum uric acid is associated with higher bone mass, lower bone tu rnover, and lower prevalence of vertebral fracture in healthy postmenopausal women. Osteoporosis Int. (2013) 24:2961–70. doi: 10.1007/s00198-013-2 377-7" 5059 5353 W3034709763.pdf 6 43 separator 0.97404104 ¶ 5353 5355 W3034709763.pdf 6 44 bibliography 0.99766296 "29. Veronese N, Bolzetta F, De Rui M, Maggi S, Noale M, Zambon S, et al. Serum uric acid and incident osteoporotic fractures in old people: the PRO.V.A study . Bone. (2015) 79:183–9. doi: 10.1016/j.bone.2015. 06.005" 5355 5577 W3034709763.pdf 6 45 separator 0.967395 ¶ 5577 5579 W3034709763.pdf 6 46 bibliography 0.9979843 "30. KimSC,PaikJM,LiuJ,CurhanGC,SolomonDH.Goutandtherisko fnon- vertebralfracture .JBoneMinerRes. (2017)32:230–6.doi:10.1002/jbmr.2978" 5579 5715 W3034709763.pdf 6 47 separator 0.9667995 ¶ 5715 5717 W3034709763.pdf 6 48 bibliography 0.9979787 "31. Mehta T, Buzkova P, Sarnak MJ, Chonchol M, Cauley JA, Wallace E, et al. Serum urate levels and the risk of hip fractures: data from the Cardiovascular Health Study . Metabolism. (2015) 64:438–46.doi:10.1016/j.metabol.2014.11.006" 5717 5956 W3034709763.pdf 6 49 separator 0.9671029 ¶ 5956 5958 W3034709763.pdf 6 50 bibliography 0.9979482 "32. Zhang D, Bobulescu IA, Maalouf NM, Adams-Huet B, Poindexter J , Park S, et al. Relationship between serum uric acid and bone mineral densit y in the generalpopulationandinratswithexperimentalhyperuricemia .JBoneMiner Res.(2015)30:992–9.doi:10.1002/jbmr.2430" 5958 6226 W3034709763.pdf 6 51 separator 0.9606538 ¶ 6226 6228 W3034709763.pdf 6 52 bibliography 0.997833 "33. Lee YH, Song GG. Uric acid level, gout and bone mineral density: a Mendelian randomization study . Eur J Clin Invest . (2019) 49:e13156.doi:10.1111/eci.13156" 6228 6394 W3034709763.pdf 6 53 separator 0.9656042 ¶ 6394 6396 W3034709763.pdf 6 54 bibliography 0.99789447 "34. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenb roucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational stu dies. Lancet. (2007)370:1453–7.doi:10.1016/S0140-6736(07)61602-X" 6396 6681 W3034709763.pdf 6 55 separator 0.9700842 ¶ 6681 6683 W3034709763.pdf 6 56 bibliography 0.9977934 "35. Makovey J, Macara M, Chen JS, Hayward CS, March L, Seibel MJ, et al. Serum uric acid plays a protective role for bone loss in peri- and postmenopausal women: a longitudinal study . Bone. (2013) 52:400– 6.doi:10.1016/j.bone.2012.10.025" 6683 6928 W3034709763.pdf 6 57 separator 0.9675927 ¶ 6928 6930 W3034709763.pdf 6 58 bibliography 0.9977935 "36. Li HZ, Chen Z, Hou CL, Tang YX, Wang F, Fu QG. Uric acid promotes osteogenic differentiation and inhibits adipogenic differenti ation of human bone mesenchymal stem cells . J Biochem Mol Toxicol . (2015) 29:382– 7.doi:10.1002/jbt.21707" 6930 7174 W3034709763.pdf 6 59 separator 0.96972454 ¶ 7174 7176 W3034709763.pdf 6 60 bibliography 0.9970659 "37. AlvimRO,SiqueiraJH,ZaniqueliD,DutraDM,OliosaPR,MillJG.I nfluence of muscle mass on the serum uric acid levels in children and adolescents . Nutr Metab Cardiovasc Dis. (2020) 30:300–5. doi: 10.1016/j.numecd.2019. 08.019" 7176 7404 W3034709763.pdf 6 61 separator 0.9838112 ¶ 7404 7406 W3034709763.pdf 6 62 text 0.76882404 "Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be c onstrued as a potentialconflictofinterest." 7406 7600 W3034709763.pdf 6 63 separator 0.95443285 ¶ 7600 7602 W3034709763.pdf 6 64 paratext 0.95864755 "Copyright © 2020 Pan, Yao, Liu and Zhu. This is an open-access arti cle distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, p rovided the original author(s) and the copyright owner(s) are credited and that th e original publication in this journal is cited, in accordance with accepted academ ic practice. No use, distributionorreproductionispermittedwhichdoesnotco mplywiththeseterms." 7602 8095 W3034709763.pdf 6 65 separator 0.74870867 ¶ 8095 8097 W3034709763.pdf 6 66 paratext 0.9817891 Frontiers in Medicine | www.frontiersin.org 7 June 2020 | Volume 7 | Article 255 8097 8178 W3034709763.pdf 6 0 paratext 0.988738 Molecules 2019 ,24, 15 14 of 17 0 31 W2905224924.pdf 13 1 separator 0.9907011 ¶ 31 33 W2905224924.pdf 13 2 text 0.9995678 "values of those genes referring to the same transcription factors were regarded as the transcription factors’ expression value. In this study, we used our previous RNA-Seq dataset for construction of the co-expression network between OPT genes and transcription factors. FPKMs of all genes including OPT genes and transcription factors were combined and used for the calculation of Spearman’s rank correlation coefficient to predict potential gene regulatory networks. The correlation coefficient ( ) for each gene pair was calculated by the built-in function “cor” in R, and a threshold of |0.85| was regarded as significant co-expression. Visualization of the network was created in Cytoscape 3.6.1 [ 70]." 33 753 W2905224924.pdf 13 3 separator 0.9962004 ¶ 753 755 W2905224924.pdf 13 4 title 0.9871043 4. Conclusions 755 770 W2905224924.pdf 13 5 separator 0.9959979 ¶ 770 772 W2905224924.pdf 13 6 text 0.9995298 "This study is the first to investigate the chromosomal location, expression profiling, and transcriptional regulation networks of P . ginseng OPT genes and provide a comparative genome analysis addressing the phylogeny, gene structure, and paralogs duplication history of the OPT gene family in P . ginseng and 11 flowering plants. Chromosomal location analyses revealed that structural variation occurred after segmental duplication, expression profiling, and transcriptional co-expression networks analyses, which indicates that both specific and pleiotropic transcription regulators might be involved in the regulation of OPT genes’ expression. Phylogenetic analyses suggested two well-supported clades in the OPT family, which can be further classified into 12 or 19 distinct groups. Motif compositions are conserved in each clade and clade-specific motifs were frequently occupied within each clade. Estimations for paralogs divergence history indicated that the majority of OPT paralogs in P . ginseng might have emerged from recent duplications, which was different from the history of Arabidopsis or cassava. The study of expression profiles in different organs and tissues of P . ginseng has provided insights into possible functional divergence among OPT members and important functional roles in the plant development of some OPT members. These data may provide valuable information for future functional investigations of this gene family." 772 2244 W2905224924.pdf 13 7 separator 0.9930476 ¶ 2244 2246 W2905224924.pdf 13 8 paratext 0.50484157 "Supplementary Materials: See the word file of “The list of supplementary materials.” All supplementary materials are available online." 2246 2382 W2905224924.pdf 13 9 separator 0.99501383 ¶ 2382 2384 W2905224924.pdf 13 10 text 0.96176517 "Author Contributions: Z.H. conceived and designed the research framework. H.C., J.X., and Y.C. prepared the sample and performed the experiments. J.X. and Y.C. provided many important suggestions for data analysis." 2384 2601 W2905224924.pdf 13 11 separator 0.89864326 ¶ 2601 2603 W2905224924.pdf 13 12 text 0.98951644 "H.S. analyzed the data. H.S. and J.X. wrote the manuscript. J.B., L.G., J.H., W.X., J.Z., X.Q, and Z.H make revisions to the final manuscript. All authors have read and approved the final manuscript." 2603 2803 W2905224924.pdf 13 13 separator 0.9948561 ¶ 2803 2805 W2905224924.pdf 13 14 text 0.9625095 "Funding: This work was supported by grants from several founds supported by Guangdong Forestry Department, Guangdong food and Drug Administration and Guangdong Provincial Bureau of traditional Chinese Medicine (2017KT1835, 2018KT1050, 2018TDZ16, 2018KT1138, 2018KT1228, and 2018KT1230), National Nature Science Foundation of China (81803672), standardized research and application of precise powder decoction pieces in traditional Chinese Medicine, and Construction Project of TCM Hospital Preparation by Special Fund of Strong Province Construction in TCM, Guangdong, China (No. 6)." 2805 3399 W2905224924.pdf 13 15 separator 0.99091464 ¶ 3399 3401 W2905224924.pdf 13 16 text 0.4459267 Conflicts of 3401 3413 W2905224924.pdf 13 17 paratext 0.40019506 Interest 3413 3422 W2905224924.pdf 13 18 text 0.6554089 : The authors declare no conflict of interest. 3422 3467 W2905224924.pdf 13 19 separator 0.9935316 ¶ 3467 3469 W2905224924.pdf 13 20 title 0.8701556 References 3469 3480 W2905224924.pdf 13 21 separator 0.9898493 ¶ 3480 3482 W2905224924.pdf 13 22 bibliography 0.9980081 "1. Stacey, M.G.; Koh, S.; Becker, J.; Stacey, G. Atopt3, a member of the oligopeptide transporter family, is essential for embryo development in Arabidopsis .Plant Cell 2002 ,14, 2799–2811. [CrossRef] [PubMed]" 3482 3694 W2905224924.pdf 13 23 separator 0.9187685 ¶ 3694 3696 W2905224924.pdf 13 24 bibliography 0.9980513 "2. Perry, J.R.; Basrai, M.A.; Steiner, H.Y.; Naider, F.; Becker, J.M. Isolation and characterization of a saccharomyces cerevisiae peptide transport gene. Mol. Cell. Biol. 1994 ,14, 104–115. [CrossRef] [PubMed]" 3696 3909 W2905224924.pdf 13 25 separator 0.8702712 ¶ 3909 3911 W2905224924.pdf 13 26 bibliography 0.99792045 "3. Steiner, H.Y.; Naider, F.; Becker, J.M. The ptr family: A new group of peptide transporters. Mol. Microbiol. 1995 ,16, 825–834. [CrossRef] [PubMed]" 3911 4064 W2905224924.pdf 13 27 separator 0.9275942 ¶ 4064 4066 W2905224924.pdf 13 28 bibliography 0.9980322 "4. Swift, S.; Throup, J.P .; Williams, P .; Salmond, G.P .; Stewart, G.S. Quorum sensing: A population-density component in the determination of bacterial phenotype. Trends Biochem. Sci. 1996 ,21, 214–219. [CrossRef]" 4066 4285 W2905224924.pdf 13 29 separator 0.8981606 ¶ 4285 4287 W2905224924.pdf 13 30 bibliography 0.9980132 "5. Kuchler, K.; Sterne, R.E.; Thorner, J. Saccharomyces cerevisiae ste6 gene product: A novel pathway for protein export in eukaryotic cells. Embo J. 1989 ,8, 3973–3984. [CrossRef] [PubMed]" 4287 4479 W2905224924.pdf 13 31 separator 0.92846817 ¶ 4479 4481 W2905224924.pdf 13 32 bibliography 0.9980166 "6. Curie, C.; Panaviene, Z.; Loulergue, C.; Dellaporta, S.L.; Briat, J.-F.; Walker, E.L. Maize yellow stripe1 encodes a membrane protein directly involved in Fe(III) uptake. Nature 2001 ,409, 346–349. [CrossRef] [PubMed]" 4481 4704 W2905224924.pdf 13 0 paratext 0.7256068 22 0 2 W3127736440.pdf 22 1 title 0.79421455 Appendix List of Interviewees Interviewee Sex Party & relevant information 3 80 W3127736440.pdf 22 2 table 0.9767437 Date of interview (dd/mm/yyyy) Nr 1 Female PSD, Portalegre, Candidate (2nd position) 5/11/2020 Nr 2 Female PSD, Lisbon, Candidate (1st position) 6/11/2020 Nr 3 Male PSD, Portalegre, Candidate (1st position) 16/11/2020 No 4 Female PS, President of women’s section 16/11/2020 Nr 5 Male PS, Lisbon, Candidate (27th position) 17/11/2020 Nr 6 Female PS, Lisbon, Candidate (2nd position) 18/11/2020 Nr 7 Male PS, Vice President of the District Federation of Portalegre 19/11/2020 80 560 W3127736440.pdf 22 0 paratext 0.81177366 This content has been downloaded from IOPscience. Please scroll down to see the full text. 0 90 W1987930566.pdf 0 1 separator 0.987763 ¶ 90 92 W1987930566.pdf 0 2 paratext 0.7649953 Download details: 92 110 W1987930566.pdf 0 3 separator 0.77373123 ¶ 110 112 W1987930566.pdf 0 4 paratext 0.66471994 IP Address: 84.97.66.88 112 136 W1987930566.pdf 0 5 separator 0.54084545 136 137 W1987930566.pdf 0 6 paratext 0.7867985 ¶ This content was downloaded on 02/02/2015 at 08:50 137 189 W1987930566.pdf 0 7 separator 0.8660903 ¶ 189 191 W1987930566.pdf 0 8 text 0.75621474 Please note that terms and conditions apply. 191 236 W1987930566.pdf 0 9 title 0.500953 Vibrating- 236 247 W1987930566.pdf 0 10 caption 0.6254978 wire measurement method for centering and 247 288 W1987930566.pdf 0 11 title 0.64626884 288 289 W1987930566.pdf 0 12 caption 0.49107158 alignment 289 298 W1987930566.pdf 0 13 title 0.48555556 of solenoids 298 311 W1987930566.pdf 0 14 separator 0.9945048 ¶ 311 313 W1987930566.pdf 0 15 text 0.6025366 View the table of contents for 313 344 W1987930566.pdf 0 16 paratext 0.5041092 this issue 344 355 W1987930566.pdf 0 17 text 0.7332157 , or go to the journal homepage for more 355 395 W1987930566.pdf 0 18 paratext 0.7998563 2013 JINST 8 P11006 395 414 W1987930566.pdf 0 19 separator 0.88629186 ¶ 414 416 W1987930566.pdf 0 20 paratext 0.85419214 (http://iopscience.iop.org/1748-0221/8/11/P11006)HomeSearch 416 476 W1987930566.pdf 0 21 title 0.6098154 Collections Journals AboutContact 476 510 W1987930566.pdf 0 22 paratext 0.45335326 us My IOPscience 510 527 W1987930566.pdf 0 0 paratext 0.98104316 "El-Gilany, A.H. ¶ www.ijehs.c om 2024, Vol. 5: e65 CC BY 4.0 2" 0 261 W4392392596.pdf 1 1 title 0.538581 Several attempts 261 278 W4392392596.pdf 1 2 text 0.6070416 "have been made over the years to measure the" 278 326 W4392392596.pdf 1 3 title 0.5956181 multidimensional characteristics 326 359 W4392392596.pdf 1 4 text 0.63401943 of ¶ 359 365 W4392392596.pdf 1 5 title 0.61441904 "HWB. This narrative review examines HWB from a public health standpoint." 365 441 W4392392596.pdf 1 6 separator 0.9518182 ¶ ¶ 444 450 W4392392596.pdf 1 7 title 0.95184386 Methods 450 458 W4392392596.pdf 1 8 separator 0.88114786 ¶ 461 463 W4392392596.pdf 1 9 text 0.9333387 "¶ Google Scholar and PubMed were searched for published full -text English papers and webpages using the key phrases ""wellbeing"" in combination with ""definition"", ""types"", ""measurement"", ""importance"", and ""challenges"" up to January 23, 2024. These combinations were created using the Boolean operators 'AND' and 'OR'. All collected literature was evaluated for inclusion in the review. We selected the most relevant articles." 465 916 W4392392596.pdf 1 10 separator 0.98645115 ¶ ¶ 918 924 W4392392596.pdf 1 11 title 0.96689624 Definition 924 935 W4392392596.pdf 1 12 separator 0.94966155 ¶ ¶ 937 943 W4392392596.pdf 1 13 text 0.99960613 "HWB can be defined in a variety of ways, including health, standard of living, human welfare, happiness, and quality of life. HWB is defined as a sense of vitality and health resulting from one's ideas, emotions, behaviors, feelings of well -being, and experiences. Wellbeing (WB) refers to feeling socially connected, happy, healthy, and meaningful most of the time (8,9). WB is defined as the development of one or more of five elements: engagement, positive feeling, meaning, relationships, and accomplishments (10)." 943 1494 W4392392596.pdf 1 14 separator 0.99088794 ¶ ¶ 1497 1503 W4392392596.pdf 1 15 title 0.99064904 HWB and related terms 1503 1525 W4392392596.pdf 1 16 separator 0.9796232 ¶ ¶ 1527 1533 W4392392596.pdf 1 17 text 0.9924507 "WB refers to a variety of ideas, including health, welfare, wellbeing, self -esteem, self -efficacy, self - determination, resilience, quality of life, mood enhancement, positive mental health, life satisfaction, and worthwhileness (11, 12). ¶ Health : According to the World Health Organization, health is ""a state of complete physical, social, and mental well -being, and not merely the absence of disease or infirmity,"" and it is a positive state for individuals and societies. It is influenced by economic, social, and environmental factors. Health is a fundamental human right (13)." 1533 2156 W4392392596.pdf 1 18 separator 0.8404101 ¶ 2158 2160 W4392392596.pdf 1 19 text 0.9995084 "The WB idea is intimately tied to mental health, and there is a two -way relationship in which the WB is both a predictor of health and a consequence of it." 2160 2323 W4392392596.pdf 1 20 separator 0.53118396 ¶ 2324 2326 W4392392596.pdf 1 21 text 0.99955 "Mental health is a positive notion that refers to the emotional and social well -being of individuals and populations. Being mentally healthy or having good mental health refers to a general condition of well - being (14,15)." 2326 2563 W4392392596.pdf 1 22 separator 0.9773042 ¶ 2566 2568 W4392392596.pdf 1 23 text 0.991047 "Happiness : It is normal to think about WB as similar to happiness. However, they have different meanings. There are three sorts of happiness: life satisfaction, pleasant feelings, and low negative feelings (9). Happiness represents a person's feelings from moment to moment, whereas WB contains happiness as well as how pleased people are with their lives, sense of independence in control of their lives, and purpose in life. Subjective well -being (SWB) is the scientific word for happiness (16, 17). ¶ Wellness is an active process of transformation and progress to achieve optimal health and well -being (18). It is a self -directed, purposeful, and ongoing process of individuals realizing their full potential to live a good and affirming life (19). Wellness encompasses a wide range of activities, including job satisfaction, physical activity, a healthy diet, and nutrition, abstaining from alcohol, tobacco, and drugs, contributing to the environment and community, creativity and mental activities, the purpose of human existence, and, finally, accepting one's own feelings (19,20). ¶ Quality of life (QOL) : WB takes into account quality of life and the contributions of individuals and societies to the global community. This encompasses prospering, equitable resource allocation, and sustainability (13). QOL is described as an individual's entire enjoyment of life, including their sense of well -being and ability to perform daily living activities. It refers to the perceived physical and mental health of an individual or group over time (21)." 2569 4232 W4392392596.pdf 1 24 separator 0.99189603 ¶ ¶ 4235 4241 W4392392596.pdf 1 25 title 0.99316704 Pillars of WB 4241 4256 W4392392596.pdf 1 26 separator 0.98926485 ¶ ¶ 4258 4264 W4392392596.pdf 1 27 text 0.98819053 "Here are the five pillars of personal well -being that should be examined collectively to create balance (9,22,23) : ¶ 1- Emotional, mental, or psychological well -being (feeling joyful) : is the ability to manage and cope with stress while being resilient and cognizant of positive emotions . ¶ 2- Physical WB (feel healthy): This involves appropriate food, physical activity, and adequate sleep to promote bodily function . ¶ 3- Social WB (feel connected): The ability to converse and build intimacy with people. This requires social abilities such as kindness, gratitude, and communication ." 4264 4905 W4392392596.pdf 1 0 bibliography 0.99792933 "3. Oldenburg C, Barnighausen T, Tanser F, et al. Antiretroviral therapy to prevent HIV acquisition in serodiscordant couples in a hyperendemiccommunity in rural South Africa. Clin Infect Dis. 2016;63:548 –554." 0 211 W2888383451.pdf 4 1 separator 0.9577298 ¶ 211 213 W2888383451.pdf 4 2 bibliography 0.99773175 "4. The INSIGHT START Study Group. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med. 2015;373:795 –807." 213 356 W2888383451.pdf 4 3 separator 0.9594443 ¶ 356 358 W2888383451.pdf 4 4 bibliography 0.99790096 "5. Hatcher AM, Smout EM, Turan JM, et al. Intimate partner violence and engagement in HIV care and treatment among women. AIDS. 2015;29: 2183 –2194." 358 511 W2888383451.pdf 4 5 separator 0.9558176 ¶ 511 513 W2888383451.pdf 4 6 bibliography 0.99804795 "6. Gonzalez JS, Batchelder AW, Psaros C, et al. Depression and HIV/AIDS treatment nonadherence: a review and meta-analysis. J Acquir Immune Defic Syndr. 2011;58:181 –187." 513 687 W2888383451.pdf 4 7 separator 0.9474654 ¶ 687 689 W2888383451.pdf 4 8 bibliography 0.99801475 "7. Malow R, Dévieux JG, Stein JA, et al. Depression, substance abuse and other contextual predictors of adherence to antiretroviral therapy (ART)among Haitians. AIDS Behav. 2013;17:1221 –1230." 689 884 W2888383451.pdf 4 9 separator 0.9452611 ¶ 884 886 W2888383451.pdf 4 10 bibliography 0.997813 "8. Oldenburg CE, Perez-Brumer AG, Reisner SL. Poverty matters: contextualizing the syndemic condition of psychological factors and newly diagnosed HIV infection in the United States. AIDS. 2014;28: 2763 –2769." 886 1102 W2888383451.pdf 4 11 separator 0.97188914 ¶ 1102 1104 W2888383451.pdf 4 12 bibliography 0.9980418 "9. Sudfeld CR, Kaaya S, Gunaratna NS, et al. Depression at antiretroviral therapy initiation and clinical outcomes among a cohort of Tanzanianwomen living with HIV. AIDS. 2017;31:263 –271." 1104 1295 W2888383451.pdf 4 13 separator 0.9707802 ¶ 1295 1297 W2888383451.pdf 4 14 bibliography 0.99795187 "10. Anderson JC, Campbell JC, Glass NE, et al. Impact of intimate partner violence on clinic attendance, viral suppression and CD4 cell count of women living with HIV in an urban clinic setting. AIDS Care. 2017;30:399 –408." 1297 1525 W2888383451.pdf 4 15 separator 0.96659946 ¶ 1525 1527 W2888383451.pdf 4 16 bibliography 0.9978769 "11. Hampanda KM, Nimz AM, Abuogi LL. Barriers to uptake of early infant HIV testing in Zambia: the role of intimate partner violence and HIVstatus disclosure within couples. AIDS Res Ther. 2017;14:17." 1527 1730 W2888383451.pdf 4 17 separator 0.9545683 ¶ 1730 1732 W2888383451.pdf 4 18 bibliography 0.9979068 "12. Minnis A, Doherty I, Kline T, et al. Relationship power, communication, and violence among couples: results of a cluster-randomized HIV prevention study in a South African township. IJWH. 2015;7:517 –519." 1732 1945 W2888383451.pdf 4 19 separator 0.9597663 ¶ 1945 1947 W2888383451.pdf 4 20 bibliography 0.99790597 "13. Shannon K, Strathdee SA, Goldenberg SM, et al. Global epidemiology of HIV among female sex workers: in fluence of structural determinants. Lancet. 2015;385:55 –71." 1947 2118 W2888383451.pdf 4 21 separator 0.96678066 ¶ 2118 2120 W2888383451.pdf 4 22 bibliography 0.9980209 "14. Baral S, Beyrer C, Muessig K, et al. Burden of HIV among female sex workers in low-income and middle-income countries: a systematicreview and meta-analysis. Lancet Infect Dis. 2012;12:538 –549." 2120 2320 W2888383451.pdf 4 23 separator 0.97094417 ¶ 2320 2322 W2888383451.pdf 4 24 bibliography 0.9979133 "15. Wilson KS, Wanje G, Yuhas K, et al. A prospective study of intimate partner violence as a risk factor for detectable plasma viral load in HIV-positive women engaged in transactional sex in Mombasa, Kenya. AIDS Behav. 2016;20:2065 –2077." 2322 2567 W2888383451.pdf 4 25 separator 0.9722481 ¶ 2567 2569 W2888383451.pdf 4 26 bibliography 0.99797016 "16 Wilson KS, Deya R, Masese L, et al. Prevalence and correlates of intimate partner violence in HIV-positive women engaged in transactional sex in Mombasa, Kenya. Int J STD AIDS. 2016; 27: 1194 –1203." 2569 2775 W2888383451.pdf 4 27 separator 0.976091 ¶ 2775 2777 W2888383451.pdf 4 28 bibliography 0.993829 "17. Schwartz S, Lambert A, Phaswana-Mafuya N, et al. Engagement in the HIV care cascade and barriers to antiretroviral therapy uptake amongfemale sex workers in Port Elizabeth, South Africa: findings froma respondent-driven sampling study. Sex Transm Infect. 2016;93:290 – 296." 2777 3060 W2888383451.pdf 4 29 separator 0.98187786 ¶ 3060 3062 W2888383451.pdf 4 30 bibliography 0.99792755 "18. Cowan FM, Mtetwa S, Davey C, et al. 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HIV self-testing among female sex workers in Zambia: a cluster randomized controlled trial.PLoS Med. 2017;14:e1002442." 3719 3883 W2888383451.pdf 4 37 separator 0.9447497 ¶ 3883 3885 W2888383451.pdf 4 38 bibliography 0.9978544 "22. Oldenburg CE, Ortblad KF, Chanda M, et al. Zambian Peer Educators for HIV Self-Testing (ZEST) Study: rationale and design of a cluster randomized trial of HIV self-testing among female sex workers inZambia. BMJ Open. 2017;20:e014780." 3885 4127 W2888383451.pdf 4 39 separator 0.96588564 ¶ 4127 4129 W2888383451.pdf 4 40 bibliography 0.9979426 "23. Duff P, Goldenberg S, Deering K, et al. Barriers to viral suppression among female sex workers. JA c q u i rI m m u n eD e fic Syndr. 2016;73:83 –90." 4129 4284 W2888383451.pdf 4 41 separator 0.9646442 ¶ 4284 4286 W2888383451.pdf 4 42 bibliography 0.9979782 "24. Lancaster KE, Cernigliaro D, Zulliger R, et al. 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Logie CH, Lacombe-Duncan A, Wang Y, et al. Pathways from HIV- related stigma to antiretroviral therapy measures in the HIV care cascadefor women living with HIV in Canada. J Acquir Immune De fic Syndr. 2018;77:144 –153.J Acquir Immune Defic Syndr /C15Volume 79, Number 4, December 1, 2018" 5644 5939 W2888383451.pdf 4 55 paratext 0.9352829 "IPV and ART Among Female Sex Workers Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. www.jaids.com |439" 5939 6070 W2888383451.pdf 4 0 paratext 0.986857 Page 16/241 0 11 W4387699146.pdf 15 0 paratext 0.9878437 Plants 2021 ,10, 261 15 of 15 0 29 W3127615012.pdf 14 1 separator 0.99219346 ¶ 29 31 W3127615012.pdf 14 2 bibliography 0.99778515 "63. Macho, A.P .; Zipfel, C. Targeting of plant pattern recognition receptor-triggered immunity by bacterial type-III secretion system effectors. Curr. Opin. Microbiol. 2015 ,23, 14–22. 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[CrossRef]" 1392 1552 W3127615012.pdf 14 15 separator 0.9674072 ¶ 1552 1554 W3127615012.pdf 14 16 bibliography 0.9978022 "70. Wu, J.; Xu, Z.; Zhang, Y.; Chai, L.; Yi, H.; Deng, X. An integrative analysis of the transcriptome and proteome of the pulp of a spontaneous late-ripening sweet orange mutant and its wild type improves our understanding of fruit ripening in citrus. J. Exp. Bot. 2014 ,65, 1651–1671. [CrossRef]" 1554 1856 W3127615012.pdf 14 0 title 0.9778191 Competing Interests 0 19 W4256121032.pdf 20 1 separator 0.9937441 ¶ 19 21 W4256121032.pdf 20 2 text 0.9673554 The authors declare there are no competing interests. 21 75 W4256121032.pdf 20 3 separator 0.9948722 ¶ 75 77 W4256121032.pdf 20 4 title 0.9858516 Author Contributions 77 98 W4256121032.pdf 20 5 separator 0.9942992 ¶ 98 100 W4256121032.pdf 20 6 text 0.96345454 "•Jason K. Moore and Sandra K. Hnat conceived and designed the experiments, performed the experiments, analyzed the data, contributed reagents/materials/analysis tools, wrote the paper, prepared figures and/or tables, reviewed drafts of the paper. •Antonie J. van den Bogert conceived and designed the experiments, contributed reagents/materials/analysis tools, wrote the paper, reviewed drafts of the paper." 100 516 W4256121032.pdf 20 7 separator 0.9968621 ¶ 516 518 W4256121032.pdf 20 8 title 0.991267 Human Ethics 518 531 W4256121032.pdf 20 9 separator 0.9935099 ¶ 531 533 W4256121032.pdf 20 10 text 0.9919846 "The following information was supplied relating to ethical approvals (i.e., approving body and any reference numbers):" 533 654 W4256121032.pdf 20 11 separator 0.5607113 ¶ 654 656 W4256121032.pdf 20 12 text 0.9908556 "The study was approved by the Institutional Review Board of Cleveland State University (# 29904-V AN-HS) and informed consent was obtained from all participants." 656 820 W4256121032.pdf 20 13 separator 0.9965998 ¶ 820 822 W4256121032.pdf 20 14 title 0.990407 Data Deposition 822 838 W4256121032.pdf 20 15 separator 0.99515265 ¶ 838 840 W4256121032.pdf 20 16 text 0.99025804 The following information was supplied regarding the deposition of related data: 840 921 W4256121032.pdf 20 17 separator 0.82125497 ¶ 921 923 W4256121032.pdf 20 18 text 0.67398185 Zenodo: 923 931 W4256121032.pdf 20 19 table 0.47774115 ¶ –http://dx.doi.org/10.5281/zenodo.1 931 969 W4256121032.pdf 20 20 text 0.47341457 3030 969 973 W4256121032.pdf 20 21 table 0.5809378 "¶ –http://dx.doi.org/10.5281/zenodo.13253 –http://dx.doi.org/10.5281/zenodo.13159 –http://dx.doi.org/10.5281/zenodo.1606" 973 1098 W4256121032.pdf 20 22 text 0.42268887 4 1098 1099 W4256121032.pdf 20 23 separator 0.99566984 ¶ 1099 1101 W4256121032.pdf 20 24 title 0.96415836 REFERENCES 1101 1112 W4256121032.pdf 20 25 separator 0.9954715 ¶ 1112 1114 W4256121032.pdf 20 26 bibliography 0.99711144 "Chester VL, Tingley M, Biden EN. 2007. 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Computing in Science & Engineering 9(3):90–95 DOI 10.1109/MCSE.2007.55." 2187 2317 W4256121032.pdf 20 39 separator 0.9810788 ¶ 2317 2319 W4256121032.pdf 20 40 bibliography 0.99786127 "Jones E, Oliphant T, Peterson P. 2001. SciPy: open source scientific tools for Python. Available at http://www.scipy.org/ ." 2319 2445 W4256121032.pdf 20 41 separator 0.9386526 ¶ 2445 2447 W4256121032.pdf 20 42 bibliography 0.9975328 "Kirtley C. 2014. CGA normative gait database. Available at http://www.clinicalgaitanalysis.com/ data/ ." 2447 2553 W4256121032.pdf 20 43 separator 0.97980416 ¶ 2553 2555 W4256121032.pdf 20 44 bibliography 0.99689686 Moore et al. (2015), PeerJ , DOI 10.7717/peerj.918 20/21 2555 2612 W4256121032.pdf 20 0 title 0.9858402 Table 4 Maternal cigarette smoking during pregnancy in relation to childhood cancer risks 0 89 W2132255205.pdf 5 1 separator 0.9874228 ¶ 89 91 W2132255205.pdf 5 2 table 0.9937341 "Before adjustment After adjustmenta Diagnostic group Cases Controls OR 95% CI OR 95% CI All cancer Nonsmoker 2958 5743 1.00 1.001–19 cpd 648 1306 0.96 0.87 1.06 0.92 0.82 1.0320+ cpd 207 528 0.76 **0.64 0.90 0.71***0.59 0.85 Trend P [0.004] [ o0.001] LeukaemiaNonsmoker 1341 5743 1.00 1.001–19 cpd 286 1306 0.95 0.83 1.10 0.93 0.80 1.0820+ cpd 95 528 0.80 0.64 1.01 0.76 *0.60 0.98 Trend P [0.069] [0.029] Lymphoma Nonsmoker 269 5743 1.00 1.001–19 cpd 60 1306 0.99 0.74 1.32 0.92 0.67 1.2620+ cpd 22 528 0.82 0.52 1.29 0.72 0.44 1.20Trend P [0.481] [0.208] CNSNonsmoker 538 5743 1.00 1.00 1–19 cpd 111 1306 0.89 0.72 1.11 0.86 0.68 1.08 20+ cpd 35 528 0.69 *0.48 0.98 0.62*0.42 0.93 Trend P [0.029] [0.011] Other solid tumoursNonsmoker 810 5743 1.00 1.001–19 cpd 191 1306 1.02 0.86 1.21 0.94 0.78 1.13 20+ cpd 55 528 0.73 *0.55 0.97 0.68*0.49 0.93 Trend P [0.123] [0.030]" 91 1001 W2132255205.pdf 5 3 separator 0.98030055 ¶ 1001 1003 W2132255205.pdf 5 4 text 0.82221884 aFor parental age and deprivation.*Po0.05;**Po0.01;***Po0.001. cpd=cigarettes per day. [ ] indicates negative trend. 1003 1120 W2132255205.pdf 5 5 separator 0.9924688 ¶ 1120 1122 W2132255205.pdf 5 6 title 0.97177255 Table 5 Parental smoking in relation to childhood cancer risks by selected diagnostic subgroups 1122 1218 W2132255205.pdf 5 7 separator 0.98000634 ¶ 1218 1220 W2132255205.pdf 5 8 table 0.9964512 "Father preconception Mother preconception Mother pregnancy Diagnostic groupaCasesbORd95% Cl CasescORd95% Cl CasescORd95% Cl 110 Acute lymphocytic leukaemia 1375 1.04 0.91 1.18 1449 1.02 0.89 1.16 1449 0.89 0.77 1.03 120 Acute myeloid leukaemia 230 1.07 0.80 1.43 249 0.82 0.60 1.12 249 0.76 0.54 1.07 130 Chronic myeloid leukaemia 22 1.44 0.59 3.50 22 1.44 0.57 3.65 22 1.70 0.68 4.26210 Hodgkin’s disease 105 1.16 0.75 1.70 114 0.75 0.47 1.19 114 0.91 0.57 1.45220 Non-Hodgkin’s lymphoma 218 1.03 0.76 1.40 229 0.90 0.65 1.23 229 0.86 0.61 1.22311 Pilocytic astrocytoma 158 1.08 0.76 1.52 169 0.89 0.62 1.28 169 0.92 0.62 1.37315 Other astrocytoma 119 0.92 0.61 1.39 132 0.94 0.62 1.43 132 0.84 0.53 1.33 320 Other glioma 66 1.09 0.64 1.84 67 0.97 0.55 1.71 67 1.12 0.63 1.99 330 Ependymoma 61 1.03 0.59 1.78 69 0.73 0.40 1.35 69 0.77 0.40 1.47340 Choroid plexus tumours 20 2.11 0.81 5.49 20 1.29 0.44 3.79 20 0.49 0.14 1.75350 Primitive neuroectodermal tumours 150 0.90 0.63 1.30 161 0.96 0.65 1.42 161 0.55 *0.34 0.88 360 Mis. brain and spinal neoplasms 61 1.33 0.77 2.28 66 0.82 0.46 1.45 66 0.74 0.39 1.40400 Retinoblastoma 86 0.66 0.40 1.09 87 0.60 0.40 1.10 87 0.60 0.30 1.10510 Neuroblastoma 180 1.35 0.97 1.88 188 1.04 0.73 1.49 188 0.91 0.62 1.34 520 Peripheral neuroectodermal tumours 74 1.12 0.68 1.80 78 1.52 0.93 2.48 78 1.48 0.88 2.47 610 Wilms’ tumour 170 1.01 0.73 1.42 182 0.82 0.57 1.17 182 0.82 0.55 1.22630 Other and unspecified renal tumours 10 1.76 0.37 8.31 12 0.98 0.26 3.71 12 0.98 0.24 3.99710 Hepatoblastoma 27 2.19 0.94 5.12 28 2.68 *1.16 6.21 28 1.10 0.44 2.72 810 Osteosarcoma 48 1.18 0.65 2.14 56 1.06 0.56 2.01 56 0.46 0.20 1.06830 Rhabdomyosarcoma 125 0.84 0.57 1.25 132 0.83 0.55 1.25 132 1.02 0.66 1.56 850 Other soft tissue sarcoma 62 0.81 0.46 1.43 69 1.02 0.57 1.80 69 0.98 0.53 1.83 910 Gonadal germ cell tumours 34 0.98 0.47 2.03 35 0.82 0.37 1.84 35 0.70 0.28 1.75920 Nongonadal germ cell tumours 57 0.81 0.46 1.46 61 0.74 0.41 1.37 61 0.53 0.25 1.10 1000 Rare miscellaneous tumours 51 1.14 0.62 2.08 57 1.21 0.66 2.22 57 1.16 0.62 2.181200 Langerhans cell histiocytosis 46 0.73 0.38 1.40 49 0.74 0.37 1.48 49 0.47 0.20 1.15" 1220 3417 W2132255205.pdf 5 9 separator 0.71663815 ¶ 3417 3419 W2132255205.pdf 5 10 table 0.7332827 aBirch–Kelsey classification (UKCCS Investigators, 2000), excluding diagnostic subgroups with less than 10 cases.bCorresponding controls: 6987.cCorresponding controls: 7581. 3419 3593 W2132255205.pdf 5 11 separator 0.51985526 ¶ 3593 3595 W2132255205.pdf 5 12 table 0.8098852 dAfter adjustment for parental age and deprivation.*Po0.05. 3595 3655 W2132255205.pdf 5 13 separator 0.7207596 ¶ 3655 3657 W2132255205.pdf 5 14 title 0.5009632 Parental smoking and childhood cancer 3657 3695 W2132255205.pdf 5 15 separator 0.88242495 ¶ 3695 3697 W2132255205.pdf 5 16 paratext 0.73356175 D Pang et al 3697 3710 W2132255205.pdf 5 17 separator 0.6531261 ¶ 3710 3712 W2132255205.pdf 5 18 paratext 0.95827675 "378 British Journal of Cancer (2003) 88(3), 373 – 381 &2003 Cancer Research UK" 3712 3793 W2132255205.pdf 5 19 separator 0.9940775 ¶ 3793 3795 W2132255205.pdf 5 20 title 0.7596516 Epidemiology 3795 3808 W2132255205.pdf 5 0 paratext 0.7478826 97 Korzystanie ze środowiska... 0 29 W2997583339.pdf 14 1 separator 0.6848594 ¶ 29 31 W2997583339.pdf 14 2 text 0.9980903 "nie jest dostatecznie jasne, o jaką postać korzystania chodzi. W literaturze wprost stwierdzono, że z mocy prawa istnieje „powszechne prawo korzystania z lasu i jego zasobów”" 31 209 W2997583339.pdf 14 3 separator 0.77108115 ¶ 209 211 W2997583339.pdf 14 4 text 0.995363 "34. Z poglądem tym, przynajmniej w odniesieniu do la - sów będących własnością Skarbu Państwa, trzeba się co do zasady zgodzić. To zaś zdaje się wskazywać, że w rozpatrywanym przypadku mamy do czynienia z rodzajem powszechnego korzystania ze środowiska 35, mimo że nie ogranicza się ono jedynie do emisji. Nie wydaje mi się bowiem możliwe przyjęcie tezy, że jest to korzystanie po części powszechne (w zakresie określonym w art. 4 ust. 1 pkt 1 pr.o.ś.), po części natomiast zwykłe (w pozostałym zakresie), gdyż ozna - czałoby, że w tym samym „zachowaniu” są elementy korzystania powszechnego i zwykłego, tymczasem zaś w świetle art. 4 pr.o.ś. korzystanie jest albo po - wszechne, albo zwykłe" 211 914 W2997583339.pdf 14 5 separator 0.7533189 ¶ 914 916 W2997583339.pdf 14 6 text 0.9549296 "36. Wątku tego, wymagającego odrębnego opracowania, nie sposób jednak rozwinąć w tym miejscu." 916 1013 W2997583339.pdf 14 7 separator 0.7934953 ¶ 1014 1016 W2997583339.pdf 14 8 text 0.89022976 państwowych i dostęp do cieków i zbiorników wodnych stanowiących własność 1016 1090 W2997583339.pdf 14 9 bibliography 0.6034599 Skarbu Pa 1090 1100 W2997583339.pdf 14 10 text 0.5036912 ństwa 1100 1105 W2997583339.pdf 14 11 bibliography 0.5933466 1106 1107 W2997583339.pdf 14 12 text 0.5937002 ¶ jest wolny 1107 1119 W2997583339.pdf 14 13 bibliography 0.98899764 "(tak A. Haładyj, J. Trzewik : Powszechne korzystanie ze środowiska na przykładzie korzystania z lasów . W: Ochrona i użytkowanie zasobów leśnych . Red. M . Woźniak, M. Koś- cielniak-Marszał . Wrocław 2015, s. 44—45)" 1119 1341 W2997583339.pdf 14 14 text 0.9909811 ". Pogląd ten budzi wątpliwości, już chociażby w świetle faktu, że zgodnie z art. 6 ust. 2 tej ustawy, szczegółowe zasady korzystania ludności z zasobów naturalnych określają odrębne przepisy, z których wynika, że ta „wolność dostępu” jest w znacznym zakresie ograniczona, a często wyłączona. Nie to jednak wydaje się najistotniej - sze. Zgodzić trzeba się bowiem z oceną A. Lipińskiego , że ustawa ta powinna być traktowana jako „swego rodzaju deklaracja polityczna”, natomiast „o tym, które elementy środowiska i do kogo należą przesądza ustawodawstwo zwykłe” ( Idem: Prawne podstawy ochrony środowiska." 1341 1960 W2997583339.pdf 14 15 separator 0.65908825 ¶ 1962 1964 W2997583339.pdf 14 16 bibliography 0.99195385 Warszawa 2010, s. 35 1964 1985 W2997583339.pdf 14 17 text 0.9839908 "). Ustawodawstwo to określa też szczegółowe zasady korzystania z po - szczególnych elementów środowiska, czego przykładem może być m.in. ustawa o lasach." 1985 2140 W2997583339.pdf 14 18 separator 0.99140275 ¶ 2141 2143 W2997583339.pdf 14 19 bibliography 0.98794055 "34 Tak M. Walas (Korzystanie ze środowiska ..., s. 110). Pogląd ten uznał za trafny W . Ra- decki (Komentarz do art. 26 ustawy o lasach . System Informacji Prawnej LEX, 2017 (wersja elektroniczna), uwaga 1)." 2143 2356 W2997583339.pdf 14 20 separator 0.82718635 ¶ 35 2356 2361 W2997583339.pdf 14 21 text 0.8993535 "Tak też A. Lipiński , który zauważył, że „niekiedy również przepisy szczególne zawierają rozwiązania dające się odczytać jako wyraz powszechnego prawa do korzystania ze środowi" 2361 2541 W2997583339.pdf 14 22 bibliography 0.5202142 - 2541 2542 W2997583339.pdf 14 23 text 0.84703135 ska, czego przykładem może być wstęp do niektórych lasów i zbiór znajdującego się tam runa 2542 2632 W2997583339.pdf 14 24 bibliography 0.6164925 ¶ leś 2633 2639 W2997583339.pdf 14 25 text 0.5901178 nego 2639 2643 W2997583339.pdf 14 26 bibliography 0.9138778 ” ( Prawne podstawy ..., s. 34). 2643 2673 W2997583339.pdf 14 27 text 0.9918407 "Poglądy w tym zakresie są jednak zróżnicowane i często wyrażane w sposób dość niejasny. I tak np. w A. Haładyj i J. Trzewik w jednym miejscu swojej wypowiedzi formułują pogląd, że mając na względzie „ogólnikowość postanowień doty - czących udostępniania ludności lasów stanowiących własność Skarbu Państwa”, można „dojść do wniosku, że w gruncie rzeczy regulują one jedynie zasady korzystania z lasów w sposób wykraczający poza korzystanie powszechne” ( Iidem : Powszechne korzystanie ... s. 44), z dru - giej natomiast po wielokroć wspominają o prawie do „powszechnego korzystania z lasów (por. zwłaszcza s. 51 i nast.). Jeśli zatem będące konsekwencją udostępnienia lasów wstęp do nich oraz pobieranie niektórych pożytków (np. runa leśnego) nie mieści się w zakresie powszechnego z nich korzystania, to powstaje pytanie, jakie zachowania wypełniają treść tego korzystania." 2673 3564 W2997583339.pdf 14 28 separator 0.9184985 ¶ 36 3565 3570 W2997583339.pdf 14 29 text 0.97343856 "Mało przekonujące w tym kontekście, a także niezbyt klarowne, jest spostrzeżenie, zgod - nie z którym „można byłoby przypuszczać”, że przepisy ustawy o lasach, „określając zasady ich udostępniania, wypełniają treść zasady powszechnego korzystania ze środowiska”, ale zasada ta „ma właściwy kontekst w odniesieniu do" 3570 3894 W2997583339.pdf 14 30 bibliography 0.8271721 3894 3895 W2997583339.pdf 14 31 text 0.8137591 tzw. prawa emisyjnego 3895 3916 W2997583339.pdf 14 32 bibliography 0.92447656 3916 3917 W2997583339.pdf 14 33 text 0.745619 "i powszechnego korzystania z wód" 3917 3952 W2997583339.pdf 14 34 bibliography 0.9740827 ” (M. Woźniak : Lasy..., s. 87). 3952 3982 W2997583339.pdf 14 35 paratext 0.94055635 Pobrano z https://opus.us.edu.pl / Downloaded from Repository of University of Silesia 2024-05-18 3982 4079 W2997583339.pdf 14 0 paratext 0.9293086 "¶ ¶ ¶ 35 ISSN : 2798 -026X (online ) DOI : 10.37905 /jirev. 3.2.26-35 Jambura Industrial Review Volume 3, No. 2, November 2023" 1 379 W4389207561.pdf 9 1 separator 0.9855257 ¶ 380 382 W4389207561.pdf 9 2 text 0.9945071 "mengalami kebocoran. Dari metode Fault tree analysis (FTA) yang digunakan, diperoleh faktor – faktor pen yebab trip pada unit Gas Turbin Generator sehingga dapat dilakukan perbaikan secara lebih terfokus pada hal yang menyebabkan kerusakan paling mendasar pada Gas Turbin." 382 665 W4389207561.pdf 9 3 separator 0.9921038 ¶ ¶ 667 673 W4389207561.pdf 9 4 title 0.9687534 DAFTAR PUSTAKA 673 688 W4389207561.pdf 9 5 separator 0.99086255 ¶ 690 692 W4389207561.pdf 9 6 bibliography 0.9974938 "E. Tanoga and P. A. Wicaksono, “Analisis Tingkat Kebisingan di Unit Utilities Pt Pertamina Ru Vi Balongan,” Ind. Eng., P. 2, 2019." 692 827 W4389207561.pdf 9 7 separator 0.9661994 ¶ 829 831 W4389207561.pdf 9 8 bibliography 0.99765915 "A. Linda , Satriyo and D. Puspitasari, “Analisis Pengendalian Kualitas Dengan Menggunakan Metode Fault tree analysis Untuk Meminimumkan Cacat Pada Crank Bed di Lini Painting Pt Sarandi Karya Nugraha,” Ind. Eng. Online J., Vol. 6, No. 1, Pp. 4 –12, 2017." 831 1094 W4389207561.pdf 9 9 separator 0.8122604 ¶ 1096 1098 W4389207561.pdf 9 10 bibliography 0.98593616 "¶ F. Situmorang, “Analisa Penerapan K3 Dengan Pendekatan Fault tree analysis Dalam Meningkatkan Produktivitas Kerja di Pt. Xyz,” Vol. 1, Pp. 1 –79, 2019." 1100 1257 W4389207561.pdf 9 11 separator 0.6436058 ¶ 1259 1261 W4389207561.pdf 9 12 bibliography 0.9929208 "¶ H. Bakhtiar, A., Sembiring, J. I., & Suliantoro, “Analisis Penyebab Kecacatan Dengan Menggunakan Metode Failure Mode and Effect Analysis (Fmea) Dan Metode Fault tree analysis (Fta) Di Pt . Alam Daya Sakti Semarang,” J. Ilm. Tek. Ind., Vol. 6, No. 2, Pp. 95 –170, 2018." 1263 1543 W4389207561.pdf 9 13 separator 0.70866066 ¶ 1545 1547 W4389207561.pdf 9 14 bibliography 0.9894871 "¶ H. Muchtar and Z. Prasetyo, “Analisa Tr ip Gas Turbin Dari Proteksi Flame Off di Pltgu Muara Tawar,” Tek. Elektro, No. Mmi, Pp. 33 –37, 2017." 1549 1696 W4389207561.pdf 9 15 separator 0.66055715 ¶ 1698 1700 W4389207561.pdf 9 16 bibliography 0.98782337 "¶ H. Silaban and A. Ghofur, “Analısa Performa Turbın Gas Tıpe Cw251 B11 Pada System Pembangkıta n Lıstrık Tenaga Gas Sektor Pembangkıtan Balı,” Vol. 2, No. 2, Pp. 161 –170, 2020." 1702 1887 W4389207561.pdf 9 17 separator 0.76551104 ¶ 1889 1891 W4389207561.pdf 9 18 bibliography 0.9878012 "¶ N. Djamal and R. Azizi, “Identifikasi Dan Rencana Perbaikan Penyebab Delay Produksi Melting Proses Dengan Konsep Fault tree analysis (Fta) Di Pt. Xyz,” J. Intech Tek. Ind., Vol. 1, No. 1, Pp. 34 –45, 2015." 1893 2107 W4389207561.pdf 9 19 separator 0.86843896 ¶ 2109 2111 W4389207561.pdf 9 20 bibliography 0.51057136 2113 2114 W4389207561.pdf 9 21 separator 0.69190776 ¶ 2114 2115 W4389207561.pdf 9 22 bibliography 0.99388826 "R. Firmansyah, “Deskrıpsı Proses Cpp Matındok Dan Sıstem Kerja Hıgh Pressure Separator 320 -D-1001 Dı Pt.Pertamına Ep Asset 4 Donggı -Matındok Fıeld,” 2019." 2115 2278 W4389207561.pdf 9 23 separator 0.7185788 ¶ 2280 2282 W4389207561.pdf 9 24 bibliography 0.98783034 "¶ S. Dhea and R. Wulan, “Analisis Defect Produk Dengan Menggunakan Metode Fmea Dan Fta Untuk Mengurangi Defect Produk ( Studi Kasus : Garment 2 Dan Garment 3 Pt Sri Rejeki Isman Tbk ),” Pp. 1 –10, 2022." 2284 2493 W4389207561.pdf 9 25 separator 0.7026281 ¶ 2495 2497 W4389207561.pdf 9 26 bibliography 0.9875573 "¶ T. Ferdiana and I. Priadythama, “Analisis De fect Menggunakan Metode Fault tree analysis (Fta) Berdasarkan Data Ground Finding Sheet (Gfs) Pt. Gmf Aeroasıa,” Pros. Semin. Nas. Ind. Eng. Conf. 2016, 2016." 2499 2711 W4389207561.pdf 9 27 separator 0.72614366 ¶ 2713 2715 W4389207561.pdf 9 28 bibliography 0.98827595 "¶ W. Y. Kartika, A. Harsono, And G. Permata, “Usulan Perbaikan Produk Cacat Menggunakan Metode Fau lt Mode and Effect Analysis Dan Fault tree analysis Pada Pt. Sygma Examedia Arkanleema,” J. Online Inst. Teknol. Nas., Vol. 4, No. 1, Pp. 345 –356, 2017." 2717 2979 W4389207561.pdf 9 29 separator 0.9937788 ¶ 2981 2983 W4389207561.pdf 9 0 paratext 0.86915267 276 KAROLINA STOJEK-SAWICKA 0 27 W4386404349.pdf 8 1 separator 0.530396 ¶ 27 29 W4386404349.pdf 8 2 paratext 0.40298507 29 30 W4386404349.pdf 8 3 title 0.5397741 ,jaki 30 35 W4386404349.pdf 8 4 text 0.79180366 35 36 W4386404349.pdf 8 5 title 0.51827073 ką 36 38 W4386404349.pdf 8 6 text 0.6559937 cik 38 41 W4386404349.pdf 8 7 title 0.46679908 w oficynach przy 41 58 W4386404349.pdf 8 8 text 0.99466985 "pałacu”6 2 , w którym mogliby w wygo­ dzie i bezpieczeństwie spędzić ostatnie lata swojego życia, a po ich śmierci zaś patron organizował im pogrzeb i pokrywał wszelkie zwią­ zane z nim wydatki6 3 . W nagrodę za pełnione usługi mianowano odda­ nych księży na dochodowe beneficja6 4 , wstawiano się za nimi u wyż­ szych władz zakonnych6 5 6 6 lub protegowano na wyższe i bardziej pre­ stiżowe godności w strukturach zakonnych bądź diecezjalnych, czę­ sto też dodatkowo ich uposażano na kolejne lata, by mogli wieść do­ statnie życie, na odpowiednim poziomie i wolne od niebezpieczeństw zewnętrznych. W każdej sytuacji mogli oni poza tym liczyć na pomoc i wsparcie patrona, który nawet po opuszczeniu przez nich jego dworu nie przestawał się dowiadywać o to, jak sobie radzili w nowym miej­ scu, wykazując żywe zainteresowanie ich losami. W przypływie szcze­ gólnej łaski nieraz też ich odwiedzał w klasztorze lub na parafii, za­ jeżdżał do nich w gościnę i wspólnie z nimi ucztował, co stanowiło w mniemaniu księży formę najwyższego uznania ze strony danego chlebodawcy i jego żywej sympatii ku gospodarzowi6 7 . Nie wszyscy jednak mogli liczyć na większe zainteresowanie patrona swoim losem w okresie choroby i starości, zależało ono bowiem w większej mierze od kryteriów emocjonalnych niż racjonalnych i od jego “afektu” względem swojego sługi. Wielu duchownych po opuszczeniu dworu Radziwiłłowskiego bez wieści przepadało w mrokach dziejów, cza­ sami tylko już po wielu latach odnajduje się jakiś adresowanych przez nich list z prośbą o prezentę na wakujące beneficjum lub protekcję w osiągnięciu wyższej godności w klasztorze, pomoc w polubownym " 58 1773 W4386404349.pdf 8 9 separator 0.9233177 ¶ 6 1773 1776 W4386404349.pdf 8 10 bibliography 0.9927103 2 A. Wołłowicz do M. K. Radziwiłła, 12 VIII 1752 z Piotrkowa, AGAD AR V 17950. 1776 1856 W4386404349.pdf 8 11 separator 0.9398339 ¶ 1856 1858 W4386404349.pdf 8 12 bibliography 0.8789414 "6 3 Expensa na wyprowadzenie ciała i na pogrzeb śp. Jmci Xiędza Dominika Antoniego de Rouchenberg guwernera Jmci Xiążąt Ichmciów ordynatów wojewodziców wileń­ skich fundatorów dnia 8 Aprila 1749 roku uczyniona , AGAD AR XXI R 70." 1858 2095 W4386404349.pdf 8 13 separator 0.98314095 ¶ 2095 2097 W4386404349.pdf 8 14 text 0.48048452 6 2097 2099 W4386404349.pdf 8 15 bibliography 0.53710794 4 2099 2101 W4386404349.pdf 8 16 text 0.92673624 "Józef Katenbring został plebanem nieświeskim (list do Karola Stanisława, 6 VI 1790 z Nieświeża, AGAD AR V nr 6535), Michał Woronicz prosił zaś o nominacje na kustosza (list do Michała Kazimierza, b. d. i m., AGAD AR V nr 18027); Jan Zda­ nowski został plebanem siebieskim, a Felicjan Zabielski plebanem mirskim." 2102 2424 W4386404349.pdf 8 17 separator 0.9728893 ¶ 2424 2426 W4386404349.pdf 8 18 bibliography 0.9751346 "6 5 Jan Poszakowski do Anny z Sanguszków, 4 V 1735 ze Słucka, AGAD AR V nr 12212 dziękuje za wstawiennictwo w wyborze na rektora kolegium słuckiego." 2426 2580 W4386404349.pdf 8 19 separator 0.958778 ¶ 2580 2582 W4386404349.pdf 8 20 bibliography 0.98797226 "6 6 Mikołaj Bykowski do Karola Stanisława, 17 VI 1785 z Nieświeża, AGAD AR V nr 1793 dziękuje za wstawienncitwo w nadaniu mu sakry biskupiej." 2582 2729 W4386404349.pdf 8 21 separator 0.97455907 ¶ 2729 2731 W4386404349.pdf 8 22 bibliography 0.99345165 "6 7 M. K. Radziwiłł, Diariusz, AGAD AR VI nr II 80-a, s. 40 (wspomina o odwiedzi­ nach u byłego guwernera, obecnego scholastyka katedralnego i audytora łuckiego, Wincentego Suchockiego), s. 1370 (pisze o pobycie na parafii u Kazimierz de La Tour, „młodości mentora”)." 2731 3010 W4386404349.pdf 8 23 title 0.9774365 TROSKI I RADOŚCI W ŻYCIU DUCHOWNYCH 277 3010 3049 W4386404349.pdf 8 24 separator 0.9739635 ¶ 3049 3051 W4386404349.pdf 8 25 text 0.9771473 rozwiązaniu konfliktów czy wsparcie finansowe w trudnej sytuacji. 3051 3117 W4386404349.pdf 8 26 separator 0.65115964 ¶ 3118 3120 W4386404349.pdf 8 27 text 0.99903095 "Opieka Radziwiłła napełniała duchownych przebywających na dworze Radziwiłłów niekłamaną radością, dawała uczucie zadowolenia i sa­ tysfakcji, przejawiające się w bardziej optymistycznym spojrzeniem na życie i często również poczuciem beztroski i spokoju, co znajdo­ wało swój wyraz w przesyłanej na ręce patrona korespondencji6 8 . Ko­ respondencja ta pełna była jednak również uczuć negatywnych, uczuć zrezygnowania i nieraz bezsilności wobec trudności i problemów ota­ czającego świata." 3120 3627 W4386404349.pdf 8 28 separator 0.9840996 ¶ 3627 3629 W4386404349.pdf 8 29 text 0.999572 "Troski i radości stanowiły bowiem dwa przeciwległe bieguny życia duchownych na dworze Radziwiłłowskim, wyznaczające rytm ich codziennej egzystencji. W niewielu miejscach różniły się one od tych doświadczanych i przeżywanych przez świeckich członków dworu nieświeskiego i były z nimi zasadniczo zbieżne w wielu aspektach dotyczących życia codziennego w ramach dworu magnackiego w wieku XVIII. Pozycja duchownych w otoczeniu Radziwiłłów była w gruncie rzeczy podobna do tej, jaką posiadały osoby świeckie; sta­ wiano przed nimi takie same wymagania, jak przed innymi członkami dworu nieświeskiego, oczekując od nich lojalności i kompetentnego wywiązywania się z podjętych zobowiązań. Z powodów religijnych nie przysługiwały duchownym żadne przywileje czy względy ze stro­ ny patrona. Podobnie jak świeccy działacze i klienci Radziwiłłowscy, również duchowni byli wystawiani na różnego rodzaju niebezpieczeń­ stwa i przykrości, będące powodem ich zmartwień i trosk, z drugiej strony doświadczali oni także wielu przyjemności, które współtworzy­ ły bieg ich życia i nieraz otrzymywali ze strony patrona dowody uznania i sympatii, dodające radosnego zabarwienia ich codziennej egzystencji." 3629 4864 W4386404349.pdf 8 30 separator 0.88087827 ¶ 6 4864 4868 W4386404349.pdf 8 31 bibliography 0.9928094 "8 Np.: Mikołaj Bykowski do Karola Stanisława, 17 VI 1785 z Białej, AGAD AR V nr 1793." 4868 4959 W4386404349.pdf 8 32 separator 0.990865 ¶ 4959 4961 W4386404349.pdf 8 0 paratext 0.9636215 "www.nature.com/scientificreports/3 SCientifiC REPORTS | 7: 17684 | DOI:10.1038/s41598-017-17716-0" 0 102 W2771787626.pdf 2 1 text 0.9983639 "particular, we found low HDL-cholesterol (high-density lipoprotein – cholesterol) in 23.1% of patients, high LDL-cholesterol (low-density lipoprotein – cholesterol) in 17.4% and high triglycerides in 12.2%. When combin-ing all four cardiometabolic risk factors, only 35.2% of adults and 48.2% of children did not have any risk factor. A total of 61 patients (24.7%) cumulated two or more risk factors. Additionally, metabolic syndrome afflicted 22 participants (8.9%) as per the International Diabetes Federation (IDF) definition and 14 adults (8.6%) using the National Cholesterol Education Program- Adult Treatment Panel (NCEP-ATP) III definition." 102 757 W2771787626.pdf 2 2 separator 0.9896457 ¶ 757 759 W2771787626.pdf 2 3 text 0.99896353 "Predictors of cardiometabolic complications among cALL survivors. Univariate analyses indicated that age at interview (per unit of year) was significantly associated with obesity (Relative risk, RR: 1.03, 95% confidence interval (CI): 1.00–1.06), dyslipidemia (RR: 1.04, 95% CI: 1.02–1.06), prediabetes (RR: 1.11, 95% CI: 1.01–1.22), metabolic syndrome as per the IDF definition (RR: 1.09, 95% CI: 1.03–1.15) and accumulating 2 or more risk factors (RR: 1.06, 95% CI: 1.02–1.09) (Table 3). Male gender was associated with pre-hypertension/ hypertension (RR: 4.10, 95% CI: 1.74–9.68) but was protective for obesity (RR: 0.60, 95% CI: 0.41–0.88). Exposure to CRT was only significantly predictive of dyslipidemia (RR: 1.56, 95% CI: 1.11–2.18) (Table 3) and particularly of high LDL-cholesterol (RR: 5.17, 95% CI: 2.11–12.68) (Supplementary Table 3). Being obese at the end of cALL treatment was significantly associated with the presence of obesity at interview (RR: 2.17, 95% CI: 1.47–3.21) and metabolic syndrome – IDF definition (RR: 3.23, 95% CI: 1.28–8.14) (Table 3). However, delta BMI percentile was not a predictor of long-term cardiometabolic complications in our cohort." 759 1955 W2771787626.pdf 2 4 separator 0.97764736 ¶ 1955 1957 W2771787626.pdf 2 5 text 0.9990721 "As outlined in Table 4 and Supplementary Table 4, multiple log-binomial regression analyses revealed that CRT exposure remained a predictor of dyslipidemia (RR: 1.60, 95% CI: 1.07–2.41) and high LDL-cholesterol (RR: 4.78, 95% CI: 1.72–13.28) along with age at interview (RR: 1.05, 95% CI: 1.01–1.08 and RR: 1.11, 95% CI 1.04–1.19 respectively). Male gender stayed a predictor for pre- and hypertension (RR: 5.12, 95% CI: 1.81–14.46) in the corresponding adjusted model, but did not remain significant for obesity. Moreover, obesity at the end of treatment was predictor of obesity at interview (RR: 2.07, 95% CI: 1.37–3.14) and metabolic syndrome (IDF defi - nition, RR: 3.04, 95% CI: 1.14–8.09). No associations were found with the variation in BMI percentile between diagnosis and the end of treatment. Of note, metabolic syndrome as defined by the NCEP-ATP III and predia-betes could not be analyzed with multiple log-binomial or Poisson regressions because of convergence problems identified by the SAS procedure PROC GENMOD." 1957 2999 W2771787626.pdf 2 6 separator 0.99475366 ¶ 2999 3001 W2771787626.pdf 2 7 title 0.7311027 Comparison to control cohort 3001 3030 W2771787626.pdf 2 8 text 0.99538314 ". Compared to CHMS controls and after adjusting for age and gender, cALL survivors were significantly at higher risk of having the metabolic syndrome (IDF definition), dyslipidemia," 3030 3214 W2771787626.pdf 2 9 table 0.70170623 "Total Adults Men Women Children Boys Girls (N = 247) (N = 162) (N = 80) (N = 82) (N " 3214 3301 W2771787626.pdf 2 10 math 0.4133531 = 3301 3302 W2771787626.pdf 2 11 table 0.5858362 85) ( 3302 3308 W2771787626.pdf 2 12 math 0.44368055 N 3308 3309 W2771787626.pdf 2 13 table 0.5436248 3309 3310 W2771787626.pdf 2 14 math 0.49705803 = 3310 3311 W2771787626.pdf 2 15 table 0.4875362 42) ( 3311 3317 W2771787626.pdf 2 16 math 0.41172698 N 3317 3318 W2771787626.pdf 2 17 table 0.612798 3318 3319 W2771787626.pdf 2 18 math 0.4424671 = 3319 3320 W2771787626.pdf 2 19 table 0.5708517 43) 3320 3324 W2771787626.pdf 2 20 separator 0.9140549 ¶ 3324 3326 W2771787626.pdf 2 21 table 0.9962079 "N (%) Obesity Normal 119 (48.2) 71 (43.8) 47 (58.7) 24 (29.3) 48 (56.5) 22 (52.4) 26 (60.5) Overweight 47 (19.0) 39 (24.1) 19 (23.8) 20 (24.4) 8 (9.4) 4 (9.5) 4 (9.3) Obesity 81 (32.8) 52 (32.1) 14 (17.50) 38 (46.3) 29 (34.1) 16 (38.1) 13 (30.2) Hypertension Normal 217 (87.9) 141 (87.0) 64 (80.0) 77 (93.9) 76 (89.4) 34 (81.0) 42 (97.7) Pre-/hypertension 30 (12.2) 21 (13.0) 16 (20.0) 5 (6.1) 9 (10.6) 8 (19.0) 1 (2.3) Prediabetes Normal 239 (96.8) 155 (95.7) 78 (97.5) 77 (93.9) 84 (98.8) 42 (100.0) 42 (97.7) Prediabetes 8 (3.2) 7 (4.3) 2 (2.5) 5 (6.1) 1 (1.2) 0 (0.0) 1 (2.3) Dyslipidemia Normal 145 (58.7) 84 (51.9) 45 (56.2) 39 (47.6) 61 (71.8) 26 (61.9) 35 (81.4) Dyslipidemia 102 (41.3) 78 (48.1) 35 (43.8) 43 (52.4) 24 (28.2) 16 (38.1) 8 (18.6) Cardiometabolic risk factors0 risk factor 98 (39.7) 57 (35.2) 35 (43.8) 22 (26.8) 41 (48.2) 15 (35.7) 26 (60.5) 1 risk factor 88 (35.6) 61 (37.7) 28 (35.0) 33 (40.2) 27 (31.8) 16 (38.1) 11 (25.6) 2 risk factors 51 (20.7) 36 (22.2) 13 (16.3) 23 (28.1) 15 (17.7) 9 (21.4) 6 (14.0) 3 risk factors 9 (3.6) 7 (4.3) 3 (3.8) 4 (4.9) 2 (2.3) 2 (4.8) 0 (0.0) 4 risk factors 1 (0.4) 1 (0.6) 1 (1.25) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) Metabolic syndrome NCEP-ATP III (N = 162) 14 (8.6) 14 (8.6) 5 (6.3) 9 (11.0) — — — IDF 22 (8.9) 19 (11.7) 9 (11.3) 10 (12.2) 3 (3.6) 3 (7.3) 0 (0.0)" 3326 4693 W2771787626.pdf 2 22 separator 0.9922905 ¶ 4693 4695 W2771787626.pdf 2 23 title 0.98881465 Table 2. Distribution of cardiometabolic outcomes in survivors of childhood acute lymphoblastic leukemia 4695 4800 W2771787626.pdf 2 24 separator 0.9784375 ¶ 4801 4803 W2771787626.pdf 2 25 text 0.7344638 "from the PETALE cohort. The number of cardiometabolic risk factors was determined by adding the presence of these four factors: obesity/overweight, pre-hypertension/hypertension, insulin" 4803 4993 W2771787626.pdf 2 26 table 0.55818295 resistance 4993 5004 W2771787626.pdf 2 27 text 0.4963098 and 5004 5008 W2771787626.pdf 2 28 table 0.5889377 dyslipidemia. NCEP-ATP III: National Cholesterol Education Program - Adult Treatment Panel III; IDF: International Diabetes Federation. 5008 5144 W2771787626.pdf 2 0 paratext 0.9640086 "Theranostics 2020, Vol. 10, Issue 11 ¶ http://www. thno.org 4808" 0 74 W3015668812.pdf 13 1 separator 0.9931607 ¶ 75 77 W3015668812.pdf 13 2 bibliography 0.9977448 Zhang K, Meng XD, Cao Y, Yang Z, Dong HF, Zhang YD, et al. Metal -Organic 47. 78 156 W3015668812.pdf 13 3 separator 0.83123934 ¶ 156 158 W3015668812.pdf 13 4 bibliography 0.993987 "Framework Nanoshuttle for Synergistic Photodynamic and Low -Temperature Photothermal Therapy. Adv Funct Mater. 2018; 28: 1804634." 158 292 W3015668812.pdf 13 5 separator 0.98310715 ¶ 294 296 W3015668812.pdf 13 6 bibliography 0.9933727 "Anderson MJ, Schaaf E, Breshears LM, Wallis HW, Johnson JR, Tkaczyk C, et 48. al. Alpha -Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates. Toxins. 2018; 10: 157." 297 497 W3015668812.pdf 13 7 separator 0.98007184 ¶ 498 500 W3015668812.pdf 13 8 bibliography 0.99779034 Yang Y, Mao M, Lei L, Li M, Yin JX, Ma XX, et al. Regulation of Water -Soluble 49. 501 584 W3015668812.pdf 13 9 separator 0.8708437 ¶ 584 586 W3015668812.pdf 13 10 bibliography 0.9893291 "Glucan Synthesis by the Streptococcus mutans DexA Gene Effects Biofilm Aggregation and Cariogenic Pathogenicity. Mol Oral Microbiol. 2019; 34: 51-63." 586 742 W3015668812.pdf 13 11 separator 0.9868928 ¶ 744 746 W3015668812.pdf 13 12 bibliography 0.9977989 Zhu YN, Zhang JM, Song JY, Yang J, Du Z. Zhao WQ, et al. A Multifunctional 50. 747 826 W3015668812.pdf 13 13 separator 0.68033195 ¶ 826 828 W3015668812.pdf 13 14 bibliography 0.99435186 "Pro‐Healing Zwitterionic Hydrogel for Simultaneous Optical Monitoring of pH and Glucose in Diabetic Wound Treatment. Adv Funct Mater. 2019; 1905493." 828 983 W3015668812.pdf 13 15 separator 0.9867125 ¶ 985 987 W3015668812.pdf 13 16 bibliography 0.9978864 Zhang XY, Zhao YQ, Zhang YD, Wang AZ, Ding XK, Li Y, et al. Antimicrobial 51. 988 1066 W3015668812.pdf 13 17 separator 0.67412925 ¶ 1066 1068 W3015668812.pdf 13 18 bibliography 0.99681425 "Peptide -Conjugated Hierarchical Antifouling Polymer Brushes for Functionalized Catheter Surfaces. Biomacromolecules. 2019; 20: 4171−4179." 1068 1210 W3015668812.pdf 13 19 separator 0.9771149 ¶ 1212 1214 W3015668812.pdf 13 20 bibliography 0.99774235 Yang X, Liu W, Xi GH, Wang MS, Liang B, Shi YF, et al. Fabricating 52. 1215 1286 W3015668812.pdf 13 21 separator 0.851761 ¶ 1286 1288 W3015668812.pdf 13 22 bibliography 0.9902246 "Antimicrobial Peptide -Immobilized St arch Sponges for Hemorrhage Control and Antibacterial Treatment. Carbohydr Polym. 2019; 222: 115012." 1288 1430 W3015668812.pdf 13 0 paratext 0.8391467 Influence of Soil Deformation Caused by Mining on Sewage Pipelines Built Using The Pipe Jacking Method 153 0 109 W2886845559.pdf 6 1 separator 0.9870726 ¶ 109 111 W2886845559.pdf 6 2 title 0.880139 References 111 122 W2886845559.pdf 6 3 separator 0.9917705 ¶ 122 124 W2886845559.pdf 6 4 bibliography 0.99722517 "[1] Batkiewicz, W. (1971). Odchylenia standardowe poeksploatacyjnych deformacji górotworu (Standard deviations of post-mining deformation of rock mass) . (Geodezja nr 10)." 124 302 W2886845559.pdf 6 5 separator 0.8304316 ¶ 303 305 W2886845559.pdf 6 6 bibliography 0.9713466 "Kraków: Polska Akademia Nauk - Oddział w Krakowie; Prace Komisji Górniczo-Geodezyjnej." 305 395 W2886845559.pdf 6 7 separator 0.9688796 ¶ 395 397 W2886845559.pdf 6 8 bibliography 0.9979972 "[2] Cheng W-Ch., Ni J.C., Arulrajah A., Huang H-W. (2018). A simple approach for characterising tunnel bore conditions based upon pipe-jacking data . Tunnelling and Underground Space Technology, 71 (2018), p. 494–504." 397 624 W2886845559.pdf 6 9 separator 0.9721028 ¶ 624 626 W2886845559.pdf 6 10 bibliography 0.9959383 "[3] Comité français pour les travaux sans tranchées (2006). Microtunnelling and horizontal drilling: French national project microtunnels: recommendations . London: ISTE." 626 803 W2886845559.pdf 6 11 separator 0.94046855 ¶ 803 805 W2886845559.pdf 6 12 bibliography 0.9962357 "[4] Hejmanowski, R., Popiołek, E., & Sroka, A. (1994). Probabilistyczna metoda oceny stopnia zagrożenia obiektów na skutek podziemnej eksploatacji górniczej (Probabilistic method to assess risk for construction works caused by underground mining operations) . Bezpieczeństwo Pracy i Ochrona Środowiska w Górnictwie. Kwartalnik WUG. Nr 1/1994, p. 55–60." 805 1176 W2886845559.pdf 6 13 separator 0.9776629 ¶ 1176 1178 W2886845559.pdf 6 14 bibliography 0.9964469 "[5] Kalisz, P . (2001). Wpływ eksploatacji górniczej na obciążenia poprzeczne rurociągów podziemnych z tworzyw sztucznych (Influence of mining operations on traverse load of underground pipelines made of plastic) . Rozprawa doktorska (Doctoral dissertation). Główny Instytut Górnictwa, Katowice." 1178 1486 W2886845559.pdf 6 15 separator 0.92034304 ¶ 1486 1488 W2886845559.pdf 6 16 bibliography 0.9971539 "[6] Kalisz, P . (2005). Probabilistyczna analiza oddziaływania eksploatacji górniczej na rurociągi wykonane metodą przeciskową (Probabilistic analysis of the influence of mining operations on pipelines built with jacking technique) . W Praca zbiorowa pod red. prof. J. Kwiatka pt. Problemy eksploatacji górniczej pod terenami zagospodarowanymi, p. 230–241." 1488 1860 W2886845559.pdf 6 17 separator 0.88468254 ¶ 1861 1863 W2886845559.pdf 6 18 bibliography 0.98955154 Katowice: Główny Instytut Górnictwa. 1863 1900 W2886845559.pdf 6 19 separator 0.9541084 ¶ 1900 1902 W2886845559.pdf 6 20 bibliography 0.9972651 "[7] Kędracki, M. (2008). Geotechnika metod bezwykopowych (Geotechnics of trenchless methods) . Łódź: Wydawnictwo Politechniki Łódzkiej." 1902 2044 W2886845559.pdf 6 21 separator 0.79737926 ¶ 2044 2046 W2886845559.pdf 6 22 bibliography 0.9974609 "[8] Kuliczkowski, A. (2003). Projektowanie konstrukcji przewodów kanalizacyjnych (Designing sewage pipelines) . Kielce: Wydawnictwo Politechniki Świętokrzyskiej." 2046 2214 W2886845559.pdf 6 23 separator 0.87348217 ¶ 2214 2216 W2886845559.pdf 6 24 bibliography 0.9970459 "[9] Kuliczkowski, A. (2011). Zalety bezwykopowych technologii budowy i odnowy sieci infrastruktury podziemnej (Advantages of trenchless methods to construct and renovate underground infrastructure). Nowoczesne Budownictwo Inżynieryjne - Technologie bezwykopowe.[10] Kwiatek, J. (1998). Ochrona obiektów budowlanych na terenach górniczych (praca zbiorowa) (Protecting buildings in mining areas) . Katowice: Główny Instytut Górnictwa." 2216 2669 W2886845559.pdf 6 25 separator 0.92661405 ¶ 2669 2671 W2886845559.pdf 6 26 bibliography 0.9970392 "[11] Kwiatek, J. (2000). Instrukcja nr 12, 1. wyd. Zasady oceny możliwości prowadzenia podziemnej eksploatacji górniczej z uwagi na ochronę obiektów budowlanych (Assessing possibility of mining operations due to protection of construction works) . Katowice: Główny Instytut Górnictwa." 2671 2969 W2886845559.pdf 6 27 separator 0.89761245 ¶ 2969 2971 W2886845559.pdf 6 28 bibliography 0.99692434 "[12] Kwiatek, J. (2006). Opracowanie probabilistycznej metody oceny skutków podziemnej eksploatacji górniczej w obiektach budowlanych (Developing probabilistic method to asssess consequences of underground mining operations in construction works) . Katowice: Główny Instytut Górnictwa." 2971 3270 W2886845559.pdf 6 29 separator 0.9028363 ¶ 3270 3272 W2886845559.pdf 6 30 bibliography 0.997094 "[13] Kwiatek, J. (2007). Obiekty budowlane na terenach górniczych (Construction works in mining areas) . Katowice: Główny Instytut Górnictwa." 3272 3420 W2886845559.pdf 6 31 separator 0.9014232 ¶ 3420 3422 W2886845559.pdf 6 32 bibliography 0.9973211 "[14] Madryas, C., Kolonko, A., & Wysocki, L. (2002). Konstrukcje przewodów kanalizacyjnych (Construction of sewage pipelines) . Wrocław: Oficyna Wydawnicza Politechniki Wrocławskiej." 3422 3611 W2886845559.pdf 6 33 separator 0.9435124 ¶ 3611 3613 W2886845559.pdf 6 34 bibliography 0.8410254 [15] Microtunneling Process . (2017). Pobrano 3613 3659 W2886845559.pdf 6 35 paratext 0.5778332 10 październik 2017, 3659 3680 W2886845559.pdf 6 36 bibliography 0.5623906 z ¶ 3680 3685 W2886845559.pdf 6 37 paratext 0.5050405 https 3685 3691 W2886845559.pdf 6 38 bibliography 0.60293573 :/ /www. 3691 3699 W2886845559.pdf 6 39 paratext 0.50733006 alnubla 3699 3706 W2886845559.pdf 6 40 bibliography 0.5259465 . 3706 3707 W2886845559.pdf 6 41 paratext 0.53989905 net 3707 3710 W2886845559.pdf 6 42 bibliography 0.50586426 /microtunneling- 3710 3726 W2886845559.pdf 6 43 paratext 0.5723202 process (10 October 3726 3745 W2886845559.pdf 6 44 bibliography 0.5768736 ¶ 3746 3748 W2886845559.pdf 6 45 paratext 0.561599 2017, 3748 3754 W2886845559.pdf 6 46 bibliography 0.48051897 3754 3755 W2886845559.pdf 6 47 paratext 0.5014165 retrieved from https 3755 3775 W2886845559.pdf 6 48 bibliography 0.5806846 :/ /www.alnubla. 3775 3791 W2886845559.pdf 6 49 paratext 0.50042963 net 3791 3794 W2886845559.pdf 6 50 bibliography 0.58718944 "/microtunneling- process)." 3794 3822 W2886845559.pdf 6 51 separator 0.9643637 ¶ 3822 3824 W2886845559.pdf 6 52 bibliography 0.9969973 "[16] Mokrosz, R. (1985). Wprowadzenie do mechaniki budowli liniowych zagłębionych w gruncie na terenach górniczych (Introduction to mechanics of linear buildings embedded into the soil in mining areas) . Warszawa: Wydawnictwo Ossolineum." 3824 4074 W2886845559.pdf 6 53 separator 0.829417 ¶ 4074 4076 W2886845559.pdf 6 54 bibliography 0.9973315 "[17] Najafi, M. (2010). Trenchless Technology Piping . New York, USA: McGraw-Hill Professional Publishing." 4076 4186 W2886845559.pdf 6 55 separator 0.8554629 ¶ 4186 4188 W2886845559.pdf 6 56 bibliography 0.9979086 "[18] Pellet-Beaucour A.-L., Kastner R. (2002): Experimental and analytical study of friction forces during microtunneling operations . Tunnelling and Underground Space Technology, 17 (2002), p. 83-97." 4188 4398 W2886845559.pdf 6 57 separator 0.90967846 ¶ 4398 4400 W2886845559.pdf 6 58 bibliography 0.99719113 "[19] Thomson, J. C. (2004). Pipejacking and microtunnelling . London: Spon Press." 4400 4485 W2886845559.pdf 6 59 separator 0.7988588 ¶ 4485 4487 W2886845559.pdf 6 60 bibliography 0.9979532 "[20] Westfall D. E., Boyce G. M. (1996). Small-Diameter Tunnels . Tunnel Engineering Handbook, p. 311-319, Chapman & Hall." 4487 4613 W2886845559.pdf 6 61 separator 0.88369966 ¶ 4613 4615 W2886845559.pdf 6 62 bibliography 0.9980166 "[21] Zhang H., Zhang P ., Zhou W., Dong S., Ma B. (2016). A new model to predict soil pressure acting on deep burial jacked pipes . Tunnelling and Underground Space Technology, 60 (2016), p . 183–196." 4615 4825 W2886845559.pdf 6 0 text 0.97032756 "clinical benefit to patients with aCML and perhaps other hematologic malignancies with NRAS mutations. Indeed, an ongoing Phase I/II clinical trial of trametinib has noted promising clinical activity in patients with RAS -mutated relapsed/refractory myeloid malignancies [9]" 0 289 W2202618438.pdf 3 1 separator 0.5374397 ¶ 289 291 W2202618438.pdf 3 2 text 0.9948733 ", and two Phase II clinical trials are underway to evaluate the safety and efficacy of trametinib treatment in combination with an AKT inhibitor for AML and multiple myeloma. When completed, the results of these studies may provide greater insight into the benefits of targeting MEK1/2 in hematologic malignancies." 291 614 W2202618438.pdf 3 3 separator 0.99625057 ¶ 614 616 W2202618438.pdf 3 4 title 0.9868489 Conclusions 616 628 W2202618438.pdf 3 5 separator 0.9957131 ¶ 628 630 W2202618438.pdf 3 6 text 0.99803925 "This case highlights the potential clinical utility of MEK1/2 inhibition in the treatment of aCML cases harboring NRAS mutations. Given the absence of an established standard of care for aCML, this report calls attention to the need for a clinical trial evaluating the safety and efficacy of trametinib in patients with NRAS -mutated aCML." 630 987 W2202618438.pdf 3 7 separator 0.99632657 ¶ 987 989 W2202618438.pdf 3 8 title 0.9818349 Additional Information 989 1012 W2202618438.pdf 3 9 separator 0.99377704 ¶ 1012 1014 W2202618438.pdf 3 10 title 0.9270737 Disclosures 1014 1026 W2202618438.pdf 3 11 separator 0.98713934 ¶ 1026 1028 W2202618438.pdf 3 12 text 0.9133101 "Human subjects: Oregon Health and Science University IRB issued approval." 1028 1105 W2202618438.pdf 3 13 separator 0.98942393 ¶ 1106 1108 W2202618438.pdf 3 14 title 0.8820621 "Conflicts of interest" 1108 1132 W2202618438.pdf 3 15 text 0.8674782 : 1132 1133 W2202618438.pdf 3 16 separator 0.8126532 ¶ 1133 1135 W2202618438.pdf 3 17 text 0.9822256 The authors have declared that no conflicts of interest exist except for the following: 1136 1224 W2202618438.pdf 3 18 separator 0.9848365 ¶ 1224 1226 W2202618438.pdf 3 19 title 0.78119737 Payment/services info 1226 1248 W2202618438.pdf 3 20 text 0.8722144 : 1248 1249 W2202618438.pdf 3 21 separator 0.68587244 ¶ 1249 1251 W2202618438.pdf 3 22 text 0.98057055 "VK is supported by a Howard Hughes Medical Institute (HHMI) Year- Long Medical Student Fellowship. While this fellowship was not directly for the purposes of the manuscript submitted here, it is a source of funding for the author." 1252 1487 W2202618438.pdf 3 23 separator 0.9968265 ¶ 1488 1490 W2202618438.pdf 3 24 title 0.8975757 Financial relationships: 1490 1515 W2202618438.pdf 3 25 separator 0.99206346 ¶ 1515 1517 W2202618438.pdf 3 26 contact 0.38441694 Jeffrey W. 1517 1528 W2202618438.pdf 3 27 text 0.43054038 Tyner declare 1528 1542 W2202618438.pdf 3 28 table 0.3366538 ( 1542 1543 W2202618438.pdf 3 29 text 0.47009352 s) Sponsored Research Agreement from Aptose Biosciences. 1543 1599 W2202618438.pdf 3 30 contact 0.46192515 Jeffrey W. 1599 1610 W2202618438.pdf 3 31 table 0.5052192 ¶ Tyner declare(s) Sponsored Research Agreement from 1610 1663 W2202618438.pdf 3 32 contact 0.3613096 Incy 1663 1668 W2202618438.pdf 3 33 text 0.3868532 te 1668 1670 W2202618438.pdf 3 34 table 0.57888144 "Corporation. Jeffrey W. Tyner declare(s) Sponsored Research Agreement from Array Bio" 1670 1757 W2202618438.pdf 3 35 text 0.32572043 pharma 1757 1763 W2202618438.pdf 3 36 table 0.545252 . Jeffrey 1763 1772 W2202618438.pdf 3 37 text 0.3399278 W 1772 1774 W2202618438.pdf 3 38 table 0.40039247 . 1774 1775 W2202618438.pdf 3 39 text 0.34893876 Tyner 1775 1781 W2202618438.pdf 3 40 table 0.5464808 "declare(s) Sponsored Research Agreement from AstraZen" 1781 1837 W2202618438.pdf 3 41 text 0.37070587 eca 1837 1840 W2202618438.pdf 3 42 table 0.44916072 . Jeffrey 1840 1849 W2202618438.pdf 3 43 text 0.31825212 W 1849 1851 W2202618438.pdf 3 44 bibliography 0.3229539 . 1851 1852 W2202618438.pdf 3 45 text 0.34400463 Tyner 1852 1858 W2202618438.pdf 3 46 table 0.4235297 declare(s) Sponsored 1858 1879 W2202618438.pdf 3 47 separator 0.37573832 1879 1880 W2202618438.pdf 3 48 bibliography 0.3704521 ¶ 1880 1881 W2202618438.pdf 3 49 table 0.48516193 Research Agreement from C 1881 1907 W2202618438.pdf 3 50 text 0.32464662 onstellation 1907 1919 W2202618438.pdf 3 51 table 0.4084743 Pharmaceuticals. 1919 1937 W2202618438.pdf 3 52 text 0.42444354 Jeffrey W. Tyner 1937 1953 W2202618438.pdf 3 53 table 0.39758006 declare(s) 1953 1965 W2202618438.pdf 3 54 bibliography 0.45652458 Sponsored 1965 1974 W2202618438.pdf 3 55 table 0.37893054 1974 1975 W2202618438.pdf 3 56 bibliography 0.41841322 ¶ Research 1975 1985 W2202618438.pdf 3 57 table 0.460189 Agreement from 1985 2000 W2202618438.pdf 3 58 bibliography 0.3343799 Genentech 2000 2010 W2202618438.pdf 3 59 table 0.43935645 / 2010 2011 W2202618438.pdf 3 60 text 0.42299214 Roche 2011 2016 W2202618438.pdf 3 61 table 0.42734414 . 2016 2017 W2202618438.pdf 3 62 text 0.41000113 Jeffrey W 2017 2027 W2202618438.pdf 3 63 bibliography 0.3484347 . 2027 2028 W2202618438.pdf 3 64 text 0.45172167 Tyner 2028 2034 W2202618438.pdf 3 65 bibliography 0.37231857 declare(s 2034 2044 W2202618438.pdf 3 66 table 0.45572177 ) 2044 2046 W2202618438.pdf 3 67 bibliography 0.53684515 Sponsored Research 2046 2064 W2202618438.pdf 3 68 table 0.37273955 2064 2065 W2202618438.pdf 3 69 bibliography 0.4789045 ¶ 2065 2066 W2202618438.pdf 3 70 table 0.45762026 2066 2067 W2202618438.pdf 3 71 bibliography 0.49449533 Agreement 2067 2076 W2202618438.pdf 3 72 table 0.4739462 from 2076 2081 W2202618438.pdf 3 73 bibliography 0.34418237 Janssen 2081 2089 W2202618438.pdf 3 74 table 0.40363997 2089 2090 W2202618438.pdf 3 75 bibliography 0.39992255 Pharmaceutical 2090 2104 W2202618438.pdf 3 76 table 0.39357877 s. 2104 2107 W2202618438.pdf 3 77 bibliography 0.3810716 Jeffrey W. 2107 2117 W2202618438.pdf 3 78 text 0.346106 Tyner 2117 2123 W2202618438.pdf 3 79 bibliography 0.41758808 declare(s) 2123 2134 W2202618438.pdf 3 80 table 0.45270607 2134 2135 W2202618438.pdf 3 81 bibliography 0.5456652 Sponsored Research 2135 2153 W2202618438.pdf 3 82 table 0.40808222 2153 2154 W2202618438.pdf 3 83 bibliography 0.48562473 ¶ 2154 2155 W2202618438.pdf 3 84 table 0.48870844 2155 2156 W2202618438.pdf 3 85 bibliography 0.4941354 Agreement 2156 2165 W2202618438.pdf 3 86 table 0.47684622 from 2165 2170 W2202618438.pdf 3 87 bibliography 0.38217324 Seattle 2170 2178 W2202618438.pdf 3 88 table 0.37874335 2178 2179 W2202618438.pdf 3 89 bibliography 0.42642742 Genetics 2179 2187 W2202618438.pdf 3 90 table 0.4145729 . 2187 2189 W2202618438.pdf 3 91 bibliography 0.47671312 Jeffrey W. Tyner declare(s) Sponsored Research Agreement 2189 2245 W2202618438.pdf 3 92 separator 0.3715492 2245 2246 W2202618438.pdf 3 93 bibliography 0.35611627 ¶ from Takeda Pharmaceutical 2246 2274 W2202618438.pdf 3 94 text 0.31256172 Company 2274 2282 W2202618438.pdf 3 95 table 0.32947135 . 2282 2283 W2202618438.pdf 3 96 text 0.3651036 Jeffrey W. Tyner 2283 2300 W2202618438.pdf 3 97 bibliography 0.35539782 declare(s) Scientific Advisory Board 2300 2337 W2202618438.pdf 3 98 separator 0.522642 ¶ 2337 2339 W2202618438.pdf 3 99 bibliography 0.35947374 Member from Leap On 2339 2359 W2202618438.pdf 3 100 text 0.3558388 cology 2359 2365 W2202618438.pdf 3 101 bibliography 0.52992404 . Brian J. Druker declare(s) Clinical Trial Support from Novartis. 2365 2431 W2202618438.pdf 3 102 separator 0.9920105 ¶ 2431 2433 W2202618438.pdf 3 103 text 0.9978977 "Dr. Druker is currently principal investigator or co-investigator on Novartis clinical trials. His institution, OHSU, has contracts with this company to pay for patient costs, nurse and data manager salaries, and institutional overhead. He does not derive salary, nor does his lab receive funds from these contracts." 2433 2756 W2202618438.pdf 3 104 separator 0.759035 2756 2757 W2202618438.pdf 3 105 text 0.98657775 . 2757 2758 W2202618438.pdf 3 106 separator 0.99670374 ¶ 2758 2760 W2202618438.pdf 3 107 title 0.9845697 Acknowledgements 2760 2777 W2202618438.pdf 3 108 separator 0.99518216 ¶ 2777 2779 W2202618438.pdf 3 109 text 0.9910167 "We gratefully acknowledge the patient himself for allowing us to share his clinical response with the scientific community. This work was supported by funds from the Howard Hughes Medical Institute (VK and BJD)." 2779 2995 W2202618438.pdf 3 110 separator 0.99656814 ¶ 2995 2997 W2202618438.pdf 3 111 title 0.77939504 References 2997 3008 W2202618438.pdf 3 112 separator 0.99219966 ¶ 3008 3010 W2202618438.pdf 3 113 bibliography 0.92722017 1 3010 3012 W2202618438.pdf 3 114 separator 0.40623444 3012 3013 W2202618438.pdf 3 115 bibliography 0.6720688 ¶ . 3013 3016 W2202618438.pdf 3 116 separator 0.93882823 ¶ 3017 3019 W2202618438.pdf 3 117 bibliography 0.9916808 "Gotlib J, Maxson JE, George TI, Tyner JW: The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment . Blood. 2013, 122:1707–11. 10.1182/blood-2013-05-500959" 3019 3236 W2202618438.pdf 3 118 separator 0.8626564 ¶ 3236 3238 W2202618438.pdf 3 119 bibliography 0.9230151 "2 ." 3238 3244 W2202618438.pdf 3 120 separator 0.9721714 ¶ 3245 3247 W2202618438.pdf 3 121 bibliography 0.9937246 "Maxson JE, Gotlib J, Pollyea DA, Fleischman AG, Agarwal A, Eide CA, Bottomly D, Wilmot B, McWeeney SK, Tognon CE, Pond JB, Collins RH, Goueli B, Oh ST, Deininger MW, Chang BH, Loriaux MM, Druker BJ, Tyner JW: Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML . N Engl J Med. 2013, 368:1781–90. 10.1056/NEJMoa1214514" 3247 3603 W2202618438.pdf 3 122 separator 0.8738527 ¶ 3603 3605 W2202618438.pdf 3 123 bibliography 0.8605831 "3 ." 3605 3611 W2202618438.pdf 3 124 separator 0.9424113 ¶ 3612 3614 W2202618438.pdf 3 125 bibliography 0.99261546 "Zoi K, Cross NC: Molecular pathogenesis of atypical CML, CMML, and MDS/MPN unclassifiable . Int J Hematol. 2015, 101:229–42. 10.1007/s12185-014-1670-3" 3614 3775 W2202618438.pdf 3 126 separator 0.9749628 ¶ 3775 3777 W2202618438.pdf 3 127 bibliography 0.69952834 2015 Khanna et al. Cureus 7(12): e 3777 3812 W2202618438.pdf 3 128 paratext 0.50338465 414 3812 3815 W2202618438.pdf 3 129 bibliography 0.607846 . DOI 10.7759/cure 3815 3833 W2202618438.pdf 3 130 paratext 0.5467748 us.414 3833 3839 W2202618438.pdf 3 131 separator 0.95389915 ¶ 3839 3841 W2202618438.pdf 3 132 paratext 0.91993845 "4 of 5" 3841 3854 W2202618438.pdf 3 0 title 0.4320977 35 0 2 W2296456805.pdf 3 1 text 0.94386965 "que diz respeito às doenças que acometem os enfermeiros e as suas condições de trabalho co - mo “provável” responsável por este adoecimen-to, cujos resultados nos proporcionará não só aprofundar os conhecimentos sobre esta temá- tica, como também propor medidas de promo - ção à saúde do trabalhador no ambiente hospi-talar, onde para sua realização estabeleceu co - mo objetivo - Identificar os problemas de saúde apresentados pelos enfermeiros no seu ambien- te de trabalho, na Rede Hospitalar Pública, Pri- vada e Filantrópica de Rio Branco – Acre - Brasil." 2 580 W2296456805.pdf 3 2 separator 0.9954256 ¶ 580 582 W2296456805.pdf 3 3 title 0.99113446 MÉTODO 582 589 W2296456805.pdf 3 4 separator 0.99579966 ¶ 589 591 W2296456805.pdf 3 5 text 0.99715525 "A pesquisa foi realizada junto a 82 (51,2%), dos 160 enfermeiros da Rede Hospitalar do mu-nicípio de Rio Branco – Acre, onde abrangeu as seguintes instituições: Hospital Geral de Clíni- cas de Rio Branco (HGCRB), Fundação Hospital Estadual do Acre (FUNDHACRE), Pronto Clínica, Hospital Santa Juliana, Urgil, Santa Casa da Mi- sericórdia do Acre, Hospital de Saúde Mental do Acre (HOSMAC) e Maternidade Bárbara Heliodo - ra (MBH), bem como junto a oito Chefes dos Ser - viços de Enfermagem." 592 1105 W2296456805.pdf 3 6 separator 0.9417662 ¶ 1105 1107 W2296456805.pdf 3 7 text 0.9989482 "Para a coleta de dados foram utilizados dois instrumentos: um formulário contendo per - guntas abertas e fechadas, destinados aos en- fermeiros assistenciais, os quais foram sortea- dos aleatoriamente, e um roteiro de perguntas aplicado às Chefias de Enfermagem, os quais fo - ram preenchidos pelas próprias pesquisadoras." 1108 1445 W2296456805.pdf 3 8 separator 0.9278259 ¶ 1445 1447 W2296456805.pdf 3 9 text 0.99949795 "Uma vez coletado os dados, estes foram agrupados de acordo com o CID – 10, OMS (1997), bem como foi utilizado o Programa EPIIN- FO 6.0, para facilitar o processamento e análise dos dados. Por sua vez, os dados qualitativos fo - ram categorizados e agrupados por semelhança de conteúdo, segundo Bardin (1995), visando a análise e interpretação dos dados. Convém esclarecer também que esta pes- quisa foi aprovada pelo Comitê de Ética em Pes- quisa, atendendo a Resolução 196/96." 1448 1946 W2296456805.pdf 3 10 separator 0.9958633 ¶ 1946 1948 W2296456805.pdf 3 11 title 0.9932679 RESULTADOS E DISCUSSÃO 1948 1971 W2296456805.pdf 3 12 separator 0.9963084 ¶ 1971 1973 W2296456805.pdf 3 13 text 0.99952036 "De acordo com a pesquisa realizada, cons- tatou-se que a maioria dos enfermeiros entre - vistados, pertencem ao gênero feminino com 76,8%, contra 23,2% do masculino, comprovan- do que a prevalência do gênero feminino na pro - fissão de enfermagem é superior ao masculino." 1974 2257 W2296456805.pdf 3 14 separator 0.8676061 ¶ 2257 2259 W2296456805.pdf 3 15 text 0.9994305 "A predominância da faixa etária dos pes- quisados foi de 30-39 anos com (35,4%), segui-do daqueles com idade menor que 30 anos e na de 40-49 anos os quais obtiveram o mesmo per - centual (26,8%). Os profissionais com idade de 50 anos e mais representaram 11,0%." 2260 2529 W2296456805.pdf 3 16 separator 0.9924114 ¶ 2529 2531 W2296456805.pdf 3 17 title 0.6993026 Com relação a condição 2532 2555 W2296456805.pdf 3 18 text 0.99021286 "marital 53,7% dos entrevistados eram casados e 34,1% solteiros. Da amostra pesquisada, 47,6% possuem filhos, ainda dependentes financeiramente estando es- tes com a faixa etária compreendida entre 5-12 anos, representando 27,4%." 2555 2795 W2296456805.pdf 3 19 separator 0.9187749 ¶ 2795 2797 W2296456805.pdf 3 20 text 0.9992987 "Quando questionado sobre o relaciona- mento com cônjuge e filhos, 48,7% classifica- ram como ótimo, ou seja, possui fácil diálogo e introsamento não apresentando problemas in- terpessoais e apenas 5,3% consideraram regu-lar (pouco diálogo e introsamento e eventuais problemas interpessoais)." 2798 3102 W2296456805.pdf 3 21 separator 0.66469926 ¶ 3102 3104 W2296456805.pdf 3 22 text 0.9990729 "Observou-se que 54,9% possuem algum título de especialização mas, atualmente 43,9% estavam cursando alguma pós-graduação." 3104 3232 W2296456805.pdf 3 23 separator 0.90235084 ¶ 3232 3234 W2296456805.pdf 3 24 text 0.9992222 "Ao discorrer sobre o estado físico e emo - cional dos entrevistados, 69,1% consideram óti- mo e bom ao chegar em casa após sua jornada de trabalho, contra 30,9% que classificaram co - mo regular e ruim." 3235 3447 W2296456805.pdf 3 25 separator 0.879094 ¶ 3447 3449 W2296456805.pdf 3 26 text 0.99610496 "Ao questionar sobre o número de locais que os enfermeiros trabalham, 42,7% respon-" 3450 3536 W2296456805.pdf 3 27 separator 0.9166114 ¶ 3536 3538 W2296456805.pdf 3 28 bibliography 0.72680783 Muniz PT , Lopes CM, Lima MP , Maia LMA, Miranda G. Nurses ́Sickness at Hospital Network at Rio Branco 3538 3640 W2296456805.pdf 3 29 paratext 0.61260206 3640 3641 W2296456805.pdf 3 30 bibliography 0.5147259 - Acre 3641 3647 W2296456805.pdf 3 31 paratext 0.9303122 "- Brazil. On- line braz j nurs [internet]. 2005 Jan [cited month day year]; 4 (1):32-41. Available from: http://www.objnursing.uff.br/index. php/nursing/article/view/5202" 3647 3822 W2296456805.pdf 3 0 paratext 0.964965 "IAJPS 2019, 06 (12), 1 5383 -15386 Hafiz Khalil Bilal et al ISSN 2349 -7750 ¶ w w w . i a j p s . c o m Page 15383 CODEN [USA]: IAJPBB ISSN: 2349 -7750 ¶ INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES ¶ Available online at: http://www.iajps.com Research Article" 0 417 W4287998741.pdf 0 1 separator 0.76739025 ¶ 419 421 W4287998741.pdf 0 2 title 0.98210025 "FREQUENCY OF DEPRESSION AMONG STUDENTS AT ALLAMA IQBAL MEDICAL COLLEGE LAHORE" 421 502 W4287998741.pdf 0 3 separator 0.9922615 ¶ 504 506 W4287998741.pdf 0 4 contact 0.94008696 "1Dr Hafiz Khalil Bilal, 2Dr Muhammad Usman Javed, 3Dr Ayesha Sadiqa 1Bhatti International Teaching Hospital Kasur , 2Sharif Medical City Hospital Lahore , 3Bahawal Victoria Hospital Bahawalpur ." 506 708 W4287998741.pdf 0 5 separator 0.96528685 ¶ 710 712 W4287998741.pdf 0 6 paratext 0.97991407 Article Received: October 2019 Accepted: November 2019 Published: December 2019 712 806 W4287998741.pdf 0 7 separator 0.9948877 ¶ 808 810 W4287998741.pdf 0 8 title 0.51831335 Abstract 810 819 W4287998741.pdf 0 9 text 0.5955789 : 819 821 W4287998741.pdf 0 10 separator 0.8755243 ¶ 822 824 W4287998741.pdf 0 11 text 0.9976087 "Background : Performance of individual is badly effected by Depression and anxiety especially those students who's are studying medical subjects." 824 973 W4287998741.pdf 0 12 separator 0.5587255 ¶ 975 977 W4287998741.pdf 0 13 text 0.99822086 "Objective: The concept of this study was to check the depression in medical students while studying MBB S at different leve ls." 977 1108 W4287998741.pdf 0 14 separator 0.7815932 ¶ 1109 1111 W4287998741.pdf 0 15 text 0.9990729 "Subjects & Methods: The pattern of this study was random and was arranged at Allama Iqbal Medical College Lahore . By using stratified systematic random sampling technique two hundred students (hundred male and hundred female) were picked out. The age of subjects was between 18 to 24 years. In Agha Khan University , depression in students was checked by using Anxiety and Depression scale and those students whose cross the score of 20 was considered as having depression. Pattren of questions was use to collect the data and this data was entered into SPSS and same software was use d to analyze the data." 1111 1737 W4287998741.pdf 0 16 separator 0.95297927 ¶ 1739 1741 W4287998741.pdf 0 17 text 0.9993428 "Results: 53 (26.50 %) out of 200 students cross the score of 20 considered as having depression while 147 (73.50%) score less than 20. In the class of 1st year of MBBS to 2nd and 3rd year frequency of depression decreases 29.27%, 25.64% and 15.15% respectively. After 3rd yea r frequency of depression increases through 4th year to final year of MBBS 25.53% and 35% respectively." 1741 2130 W4287998741.pdf 0 18 separator 0.9635062 ¶ 2132 2134 W4287998741.pdf 0 19 text 0.9996379 "Conclusion: Depression is spreading woth high rate in medical students. Emotional distress causes increase in depression when students enter into course which decreases upto third year. After third year it rised due to hard work in clinics and duties in wards. Academic burden in final year, to feel that their goal is on few step and thinking about future responsibilities makes more stress in MBBS course." 2134 2552 W4287998741.pdf 0 20 separator 0.9948013 ¶ 2554 2556 W4287998741.pdf 0 21 contact 0.96478295 "Corresponding author: Dr. Hafiz Khalil Bilal , Bhatti International Teaching Hospital Kasur. ¶ ¶" 2556 2669 W4287998741.pdf 0 22 separator 0.86871445 ¶ ¶ 2671 2677 W4287998741.pdf 0 23 paratext 0.74949163 Please cite this article in press 2677 2711 W4287998741.pdf 0 24 bibliography 0.705037 "Hafiz Khalil Bilal et al., Frequency Of Depression Among Students At Allama Iqbal Medical College Lahore ., Indo Am. J. P. Sci ," 2711 2844 W4287998741.pdf 0 25 paratext 0.7252667 "2019; 06(12). ¶ QR code" 2844 2878 W4287998741.pdf 0 26 separator 0.8645983 "¶ ¶" 2880 2890 W4287998741.pdf 0 0 bibliography 0.75204444 Zhang et al. /one.tnum/zero.tnum./three.tnum/three.tnum/eight.t 0 63 W4323315993.pdf 5 1 paratext 0.48834106 num/nine 63 71 W4323315993.pdf 5 2 bibliography 0.47326627 . 71 72 W4323315993.pdf 5 3 paratext 0.6109757 tnum/fneur./two.tnum/zero.tnum/two.tnum/three.tnum./one.tnum/one.tnum/two.tnum/zero.tnum/four.tnum/four.tnum/six.tnum 72 189 W4323315993.pdf 5 4 separator 0.97701174 ¶ 189 191 W4323315993.pdf 5 5 bibliography 0.9979194 "6. Liu FJ, Xu HH, Yin Y, Chen YZ, Xie LY, Li HZ. Decreased adipone ctin levels are a risk factor for cognitive decline in spinal cord inju ry.Disease Markers. (2022).doi:10.1155/2022/5389162" 191 386 W4323315993.pdf 5 6 separator 0.9498767 ¶ 386 388 W4323315993.pdf 5 7 bibliography 0.997659 "7. 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(2021) 107:1– 10.doi:10.1016/j.neurobiolaging.2021.07.001" 5412 5770 W4323315993.pdf 5 48 separator 0.96877366 ¶ 5770 5772 W4323315993.pdf 5 49 bibliography 0.9978894 "29. DekensDW,NaudéPJ,EngelborghsS,VermeirenY,VanDamD, OudeVoshaar RC, et al. Neutrophil gelatinase-associated lipocalin and its rec eptors in Alzheimer’s disease (AD) brain regions: differential findings in AD with a nd without depression. J Alzheimer’sDis. (2017)55:763–76.doi:10.3233/JAD-160330" 5772 6073 W4323315993.pdf 5 50 separator 0.9607408 ¶ 6073 6075 W4323315993.pdf 5 51 bibliography 0.99774694 "30. NaudéP,denBoerJ,ComijsH,BoskerF,ZuidersmaM,Groene woldN,etal.Sex- specific associations between neutrophil gelatinase-associa ted Lipocalin (NGAL) and cognitive domains in late-life depression. Psychoneuroendocrinology. (2014) 48:169– 77.doi:10.1016/j.psyneuen.2014.06.016" 6075 6357 W4323315993.pdf 5 52 separator 0.97088665 ¶ 6357 6359 W4323315993.pdf 5 53 bibliography 0.997839 "31. Behrens V, Voelz C, Müller N, Zhao W, Gasterich N, Clarner T, et al. Lipocalin 2 as a putative modulator of local inflammatory processes in the spin al cord and componentoforgancrosstalkafterspinalcordinjury. MolNeurobiol. (2021)58:5907– 19.doi:10.1007/s12035-021-02530-7" 6359 6640 W4323315993.pdf 5 54 separator 0.9544688 ¶ 6640 6642 W4323315993.pdf 5 55 bibliography 0.9978107 "32. Rathore KI, Berard JL, Redensek A, Chierzi S, Lopez-Vales R , Santos M, et al. Lipocalin 2 plays an immunomodulatory role and has detrimenta l effects after spinal cord injury. J Neurosci. (2011) 31:13412–9. doi: 10.1523/JNEUROSCI. 0116-11.2011" 6642 6896 W4323315993.pdf 5 56 separator 0.9418055 ¶ 6896 6898 W4323315993.pdf 5 57 paratext 0.9656918 Frontiersin Neurology /zero.tnum/six.tnum frontiersin.org 6898 6956 W4323315993.pdf 5 0 paratext 0.9657025 "International Journal of Environmental Research and Public Health" 0 72 W3016712102.pdf 0 1 separator 0.64411247 ¶ 72 74 W3016712102.pdf 0 2 title 0.49193814 Article 74 82 W3016712102.pdf 0 3 separator 0.56551975 82 83 W3016712102.pdf 0 4 title 0.9558065 "¶ Comorbidities and Outcome of Alcoholic and Non-Alcoholic Liver Cirrhosis in Taiwan:" 83 170 W3016712102.pdf 0 5 separator 0.5861182 ¶ 170 172 W3016712102.pdf 0 6 title 0.9772518 A Population-Based Study 172 197 W3016712102.pdf 0 7 separator 0.9943875 ¶ 197 199 W3016712102.pdf 0 8 contact 0.5772371 Tzu-Wei Yang1,2,3 199 217 W3016712102.pdf 0 9 table 0.5260301 , 217 218 W3016712102.pdf 0 10 contact 0.5257281 Chi-Chih Wang 218 232 W3016712102.pdf 0 11 table 0.5562917 "1,2,3 ," 232 241 W3016712102.pdf 0 12 contact 0.6094099 Ming-Chang Tsai1,2,3 241 262 W3016712102.pdf 0 13 table 0.49069443 , 262 263 W3016712102.pdf 0 14 contact 0.7354767 "Yao-T ung Wang1,2,4, Ming-Hseng Tseng5,6,*,y and Chun-Che Lin7,8,*,y" 263 336 W3016712102.pdf 0 15 separator 0.9620672 ¶ 336 338 W3016712102.pdf 0 16 contact 0.99646723 "1School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan; joviyoung@gmail.com (T.-W.Y.); bananaudwang@gmail.com (C.-C.W.); tmc1110@yahoo.com.tw (M.-C.T.); wangyt@ms9.hinet.net (Y.-T.W.)" 338 542 W3016712102.pdf 0 17 separator 0.6616684 ¶ 542 544 W3016712102.pdf 0 18 contact 0.98666656 "2Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 3Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan 4Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan 5Department of Medical Informatics, Chung Shan Medical University, Taichung 402, Taiwan 6Information Technology O ce, Chung Shan Medical University Hospital, Taichung 402, Taiwan 7Department of Internal Medicine, China Medical University Hospital, Taichung 404, Taiwan 8School of Medicine, China Medical University, Taichung 404, Taiwan *Correspondence: mht@csmu.edu.tw du.tw (M.-H.T.); D83949@mail.cmuh.org.tw (C.-C.L.)" 544 1327 W3016712102.pdf 0 19 separator 0.9019493 ¶ 1327 1329 W3016712102.pdf 0 20 paratext 0.9195281 yThese authors contributed equally to this work. 1329 1378 W3016712102.pdf 0 21 separator 0.82412946 ¶ 1378 1380 W3016712102.pdf 0 22 paratext 0.9783986 "Received: 14 March 2020; Accepted: 14 April 2020; Published: 20 April 2020 /gid00030/gid00035/gid00032/gid00030/gid00038/gid00001/gid00033/gid00042/gid00045 /gid00001 /gid00048/gid00043/gid00031/gid00028/gid00047/gid00032/gid00046" 1380 1615 W3016712102.pdf 0 23 separator 0.9941747 ¶ 1615 1617 W3016712102.pdf 0 24 text 0.997006 "Abstract: The prognosis of di erent etiologies of liver cirrhosis (LC) is not well understood. Previous studies performed on alcoholic LC-dominated cohorts have demonstrated a few conflicting results. We aimed to compare the outcome and the e ect of comorbidities on survival between alcoholic and non-alcoholic LC in a viral hepatitis-dominated LC cohort. We identified newly diagnosed alcoholic and non-alcoholic LC patients, aged 40 years old, between 2006 and 2011, by using the Longitudinal Health Insurance Database. The hazard ratios (HRs) were calculated using the Cox proportional hazards model and the Kaplan–Meier method. A total of 472 alcoholic LC and 4313 non-alcoholic LC patients were identified in our study cohort. We found that alcoholic LC patients were predominantly male (94.7% of alcoholic LC and 62.6% of non-alcoholic LC patients were male) and younger (78.8% of alcoholic LC and 37.4% of non-alcoholic LC patients were less than 60 years old) compared with non-alcoholic LC patients. Non-alcoholic LC patients had a higher rate of concomitant comorbidities than alcoholic LC patients (79.6% vs. 68.6%, p<0.001). LC patients with chronic kidney disease demonstrated the highest adjusted HRs of 2.762 in alcoholic LC and 1.751 in non-alcoholic LC (all p<0.001). In contrast, LC patients with hypertension and hyperlipidemia had a decreased risk of mortality. The six-year survival rates showed no di erence between both study groups ( p=0.312). In conclusion, alcoholic LC patients were younger and had lower rates of concomitant comorbidities compared with non-alcoholic LC patients. However, all-cause mortality was not di erent between alcoholic and non-alcoholic LC patients." 1617 3357 W3016712102.pdf 0 25 separator 0.99215376 ¶ 3357 3359 W3016712102.pdf 0 26 text 0.42764586 Keywords: alcoholic liver cirrhosis; non-alcoholic liver cirrhosis; survival; comorbidity 3359 3449 W3016712102.pdf 0 27 separator 0.9968387 ¶ 3449 3451 W3016712102.pdf 0 28 title 0.97564214 1. Introduction 3451 3467 W3016712102.pdf 0 29 separator 0.9957714 ¶ 3467 3469 W3016712102.pdf 0 30 text 0.99573636 "Liver cirrhosis (LC) resulting from di erent etiologies is a leading cause of death, which accounts for 3.5% of all death worldwide [ 1,2]. The leading cause of LC is alcohol-related liver disease in" 3469 3672 W3016712102.pdf 0 31 separator 0.9029856 ¶ 3672 3674 W3016712102.pdf 0 32 paratext 0.9496788 Int. J. Environ. Res. Public Health 2020 ,17, 2825; doi:10.3390 /ijerph17082825 www.mdpi.com /journal /ijerph 3674 3784 W3016712102.pdf 0 0 text 0.7003526 hyperresponsiveness, airway in 0 30 W3127347390.pdf 9 1 title 0.5540248 flamm 30 35 W3127347390.pdf 9 2 text 0.9883337 "ation, and mucus overproduction in OVA-challenged mice were suppressed byAH treatment. It has been demonstrated that herbal medicineswith anti-in flammatory effects markedly attenuate airway inflammation and airway hyperresponsiveness via inhibition of Th2 cytokine production in the OVA-challenged asthma model(Asma et al., 2017 ;Sung et al., 2019 ). Therefore, these findings suggest that AH treatment effectively inhibited OVA-challengedallergic asthma via suppression of Th2 cytokines." 35 529 W3127347390.pdf 9 3 separator 0.9855723 ¶ 529 531 W3127347390.pdf 9 4 text 0.99959826 "The in flammatory response during allergic asthma is due to activation of the major transcription factor NF- κB(Wang et al., 2017 ). Upon activation, I κB kinase phosphorylates NF- κB. The p65-p50 dimer of NF- κB is then translocated into the nucleus where it binds to DNA to regulate the expression of Th2 cytokinesand MUC5AC in allergic asthma ( Xie et al., 2015 ). MUC5AC is a major component of airway mucus. In asthmatic patients, MUC5AC expression is elevated by goblet cells, leading toairway limitation ( Shin et al., 2019b ,Song et al., 2005 ). In addition, MAPKs also regulate the expression of Th2cytokines, and can affect the differentiation of in flammatory cells, such as Th2 cells and eosinophils. In a previous study,activation of MAPKs/NF- κB signaling was considered an important factor in the development of allergic asthma(Chauchan et al., 2018 ). In our study, AH-treated asthmaticmice exhibited a signi ficant decrease in the phosphorylation of MAPKs/p65NF- κB and MUC5AC expression. These results are consistent with the results of our in vitro experiments. Several studies reported that blocking of MAPKs/NF- κB signaling led to significant decreases in Th2 cytokines and a reduction in mucus overproduction, leading to reduction of airway in flammation in the OVA-challenged asthmatic mouse model ( Asma et al., 2017 ; Chauchan et al., 2018 ;Fengjuan et al., 2019 ). Thus, our results indicate that anti-asthmatic effects of AH treatment on OVA-challenged airway in flammation and mucus overproduction may be associated with inhibition of MAPKs/NF- κB, resulting in suppression of MUC5AC expression." 531 2188 W3127347390.pdf 9 5 separator 0.9889817 ¶ 2188 2190 W3127347390.pdf 9 6 text 0.9981133 "AH is widespread in the Eastern Asia and is used in traditional medicine as a remedy for hemorrhage, fever, and diarrhea ( Lee, 1996). The AH branches were collected from Gangwon Province (Gangwon-do, South Korea) in April of 2016. The AH extracted with 99.9% methyl alcohol at room temperature and collected fromThe Korea Plant Extract Bank of KRIBB (PB2357.6). The AH isreported to contain rubranoside A, hirsutanonol 5-O- β-D- glucopyranoside, platyphyllenone and oregonin ( Park et al., 2010). According to previous studies in LPS-stimulated RAW264.7 cells, the antioxidant effect of AH may be due tothe suppression of ROS and NO production, while its anti-inflammatory properties of AH include inhibition of " 2190 2917 W3127347390.pdf 9 7 separator 0.93813795 ¶ 2917 2918 W3127347390.pdf 9 8 caption 0.99562824 "FIGURE 7 | AH inhibited phosphorylation of p65NF- κB and I κB-αin TNF- α-stimulated NCI-H292 cells. β-actin was used to con firm equal protein loading. The culture medium were changed RPMI1640 (0.1% FBS) and treated with AH (20, 40 and 80 μg/ml) for 1 h and incubated with TNF- α(30 ng/ml) for 30 min. The values are expressed as the means ±SD (n /equals3).##p<0.01, Signi ficantly different from control;††p<0.01, signi ficantly different from TNF- α-treated group." 2918 3386 W3127347390.pdf 9 9 separator 0.97607535 ¶ 3386 3388 W3127347390.pdf 9 10 paratext 0.96338224 Frontiers in Pharmacology | www.frontiersin.org February 2021 | Volume 12 | Article 614442 10Lee et al. 3388 3492 W3127347390.pdf 9 11 title 0.6951055 Antiasthmatic Effects of Alnus Hirsuta 3492 3531 W3127347390.pdf 9 0 separator 0.88031137 ¶ 1 2 W3202081438.pdf 0 1 title 0.7087187 Eat Behavior Muara Goat 2 27 W3202081438.pdf 0 2 paratext 0.5261501 ( Cap 27 33 W3202081438.pdf 0 3 title 0.48897952 ra 33 35 W3202081438.pdf 0 4 paratext 0.47316864 aeg 35 39 W3202081438.pdf 0 5 title 0.51170266 agrushircus 39 50 W3202081438.pdf 0 6 paratext 0.53346545 ) in 50 55 W3202081438.pdf 0 7 title 0.49158412 the 55 59 W3202081438.pdf 0 8 paratext 0.59882176 ¶ village of Batubinumbun, Muara, North Tapanuli Regency 60 117 W3202081438.pdf 0 9 separator 0.8909723 ¶ ¶ 119 125 W3202081438.pdf 0 10 contact 0.9837505 "H H Silitonga , Hamdan , I Sembiring , N Ginting, and Hasnudi ¶ Animal Production Program, Faculty of Agriculture , Universit y of Sumatera Utara , Meda n 20155, Indonesia E-mail : ipassimare@gmail.com" 125 341 W3202081438.pdf 0 11 separator 0.96249676 ¶ ¶ 343 349 W3202081438.pdf 0 12 text 0.6415068 Abstract 349 358 W3202081438.pdf 0 13 separator 0.8161863 358 359 W3202081438.pdf 0 14 text 0.9951535 ". Goat eating behavior can support nutrition of goat feed. This information is important for farmers in an attempt for Muara condition the environment and design the appropriate management needs go ats. This research was conducted in July and August 2016." 359 620 W3202081438.pdf 0 15 separator 0.91607773 ¶ 621 623 W3202081438.pdf 0 16 text 0.9993284 "Livestock were used as many as 30 individuals. Eating behavioral observations performed on four groups, namely: group I (adult males and adult females with a ratio of 1: 9), Group II (adult males an d adult females with a ratio of 1: 4), Group III (young male 6 tails and females young or virgin 4 individuals) and group IV (tiller consists of 2 males and females tails 3 tails). Research method was One Zero with a 15 minute interval performed on at 08.0 0-12.00." 623 1100 W3202081438.pdf 0 17 separator 0.839381 ¶ 1101 1103 W3202081438.pdf 0 18 text 0.99897826 "The results showed higher feeding activity compared to activity of rumination, the group with the highest feeding activity in the goat group samplings, rumination activity while highest in the group of adult goat." 1103 1323 W3202081438.pdf 0 19 separator 0.9776612 ¶ 1325 1327 W3202081438.pdf 0 20 text 0.9734281 Keywords : goat, behavior, eat 1327 1359 W3202081438.pdf 0 21 separator 0.99570775 ¶ ¶ 1361 1367 W3202081438.pdf 0 22 title 0.9847573 1. Introduction 1367 1383 W3202081438.pdf 0 23 separator 0.99455464 ¶ 1385 1387 W3202081438.pdf 0 24 text 0.9948034 "The need for animal protein for Indonesians increases every year, in line with population growth. One of the efforts to meet the protein needs is to improve the cultivation of livestock. Commodities that still have potential to be developed in Indonesia are goats. Various efforts have been made to increase goat production, among others by crossing between local species with superior species." 1387 1791 W3202081438.pdf 0 25 separator 0.88051015 ¶ 1793 1795 W3202081438.pdf 0 26 text 0.99939835 "Goats are the first animals to be domesticated by humans. It is estimated that at first the hunters brought back the goats from the prey. The goats are kept in the village as pets, then used for milk, meat and skin [1]." 1795 2021 W3202081438.pdf 0 27 separator 0.9203745 ¶ 2022 2024 W3202081438.pdf 0 28 text 0.99868476 "Goat population growth tends to increase every year. In 2012 the number is 17,433,000, while in 2013 the number has increased to 17,905,86 0. More than half of goats in Indonesia are spread over Java Island, while on the island of Sumatra, about half the goat population in Java. The population of goats on the island of Sumatra and Java is about 82.7% of the total population of goats. The rest , less than 20% spread over several islands, ranging from the most numerous, namely Sulawesi, Bali, Nusa Tenggara, Maluku, Kalimantan, and Papua. Central Java is the province with the largest livestock population, while Bangka Belitung is the province with the lowest population [2]." 2024 2723 W3202081438.pdf 0 29 separator 0.9750756 ¶ 2724 2726 W3202081438.pdf 0 30 text 0.99810976 Goat estuaries are found in the district of Muara, North Tapanuli regency in North Sumatra province. 2726 2827 W3202081438.pdf 0 31 separator 0.8733339 ¶ 2828 2830 W3202081438.pdf 0 32 text 0.99895716 "Appearance of this goat looks dashing, her body is compact and the color distribution of fur varies between the color of reddis h brown fur, white and there is also colored black fur. The weight of goat estuary is bigger compared to goat bean and allegedly prolific goat. Needs of goat meat in North" 2830 3136 W3202081438.pdf 0 0 paratext 0.96554667 "Tan et al. 10.3389/fpsyg.2024.1301662 Frontiers in Psychology 08 frontiersin.org" 0 82 W4396733729.pdf 7 1 title 0.95706254 TABLE 4 Regression analysis of maternal autonomy support and mindfulness, self-esteem and depression symptoms. 82 193 W4396733729.pdf 7 2 separator 0.9763191 ¶ 193 195 W4396733729.pdf 7 3 table 0.9953384 "Result variable Predictive variable R R2F β t Depressive symptomsAge 0.56 0.31 131.81 ***0.03 1.22 Gender −0.03 −1.28 SES 0.04 1.79 MAS −0.55 −22.72*** MindfulnessAge 0.57 0.33 144.18 ***0.02 0.88 Gender −0.03 −1.23 SES 0.03 1.18 MAS 0.58 23.93*** Self-esteemAge 0.79 0.61 377.02 ***0.01 0.59 Gender −0.001 −0.04 SES 0.27 1.50 MAS 0.44 19.85*** Mindfulness 0.45 20.18*** Depressive symptomsAge 0.74 0.55 239.57 ***0.04 2.26* Gender −0.05 −2.42* SES 0.07 3.43*** MAS −0.10 −3.68*** Mindfulness −0.42 −15.10*** Self-esteem −0.30 −9.61***" 195 777 W4396733729.pdf 7 4 separator 0.8910029 ¶ 777 779 W4396733729.pdf 7 5 table 0.8235144 MAS, maternal autonomy support; SES, socioeconomic status; *p < 0.05, ***p < 0.001. 779 863 W4396733729.pdf 7 6 separator 0.69573903 ¶ 863 865 W4396733729.pdf 7 7 text 0.9675049 "excluding 0; indicating that the indirect path has a significant mediating effect. Therefore, H2 and H3 were supported." 865 988 W4396733729.pdf 7 8 separator 0.9359133 ¶ 988 990 W4396733729.pdf 7 9 text 0.998336 "As the effects of paternal autonomy support and maternal autonomy support on depressive symptoms are considered separately, this study further conducted relative weights analysis to compare whether there are significant differences among different mediating effects (see Table 6 ). The comparison results of indirect effects show that there were no significant differences among the four indirect effects. Thus, the autonomy support of parents is equally important to individual’s development." 990 1502 W4396733729.pdf 7 10 title 0.92160183 Discussion 1502 1512 W4396733729.pdf 7 11 separator 0.99273694 ¶ 1512 1514 W4396733729.pdf 7 12 text 0.99820113 "Depressive symptoms are a frequently reported mood disorder among college students, which have many negative effects on their academics and future career development ( Bayram and Bilgel, 2008 ; Pittman and Richmond, 2008 ). It is critical to investigate depressive symptoms among college students to assist individuals to successfully transition through this time. Under the framework of self- determination theory, this study explores the relationship between " 1514 1994 W4396733729.pdf 7 13 separator 0.8552554 ¶ 1994 1995 W4396733729.pdf 7 14 caption 0.926547 FIGURE 4 1995 2004 W4396733729.pdf 7 15 separator 0.8865197 ¶ 2004 2006 W4396733729.pdf 7 16 caption 0.99167395 Mediation effect model. MAS, maternal support. *** p < 0.001. 2006 2069 W4396733729.pdf 7 0 text 0.9992212 "In this sense, we believe that those relating to electoral processes should be included as high -risk AI systems, nor does it apply to technologies in the field of advertising, nor that it would affect consumer privacy in general t erms." 0 243 W3199976308.pdf 2 1 separator 0.9689423 ¶ 245 247 W3199976308.pdf 2 2 text 0.9996951 "In this sense, a situation of urgency duly justified in the third paragraph of said article is also regulated, which in no way is defined, but to which, in addition, is added the counterproductive situation that after the AI system is used, the au thorization can be granted, when already at that time such a concession would not make any sense, so in our opinion, although it is not wrong for such a situation to occur, the truth is that for this to happen, in no way can the concession be established a fter its use. I also consider in this regard the inclusion of the prohibition of the use of AI systems that cause or are expected to cause damage to the environment in any of its forms." 247 963 W3199976308.pdf 2 3 separator 0.99040854 ¶ 965 967 W3199976308.pdf 2 4 text 0.9996831 "In the specific case of the requirements established in Chapter 2 for high -risk AI systems, it is proposed in relation to paragraph 8, that this be a prohibition and not a suggestion, if we take into account the repercussions that this may have on minors and always taking into account that this would guarantee compliance wi th the postulates of the Convention on the Rights of the Child." 967 1368 W3199976308.pdf 2 5 separator 0.9793875 ¶ 1370 1372 W3199976308.pdf 2 6 text 0.9994908 "Article 15 whose purpose is to make clear the conditions of precision, robustness , and cybersecurity that must meet high -risk AI systems, in its Section 4 must regulate other conditions that may arise in terms of vulnerability and what to do in these situations." 1372 1643 W3199976308.pdf 2 7 separator 0.98222804 ¶ 1645 1647 W3199976308.pdf 2 8 text 0.9996715 "The White Paper suggests that in the regulatory framework of intelligence s ystems as part of the Trust Ecosystem, within its requirements that of record and data conservation, this was established in the Regulation of Artificial Intelligence specifically for high -risk AI systems in Article 12 in relation to 20, which in our opini on should be expanded and deepened taking into account the complexity and opacity of many of these systems and the difficulties that may arise in this regard, which would allow effective verification of compliance with the applicable rules and execute them , because in said Article in the first order, as we had already mentioned, this requirement is established for high -risk AI systems, without mentioning the rest of the AI systems, such as those with low or minimum risk, which due to certain failures in the ir systems can suddenly become high risk, in a second order it is wise to regulate the period of time that these records will be kept, which must be limited and reasonable, but must be defined, all in order to facilitate the monitoring and verification of the actions and decisions of these systems. Moreover, the conservation of documentation on programming methodologies, process training , and techniques used to build, test , and validate AI systems should be regulated . Here we could also add the conserva tion and recording of the data set used to train and test AI systems." 1647 3119 W3199976308.pdf 2 9 separator 0.98799634 ¶ 3121 3123 W3199976308.pdf 2 10 text 0.999658 "In the specific case of human surveillance established in Article 14 of the regulation, or what is the same human supervision, in addition to the objectives set out in its paragraph (2) it must be added at our discretion that this will also be in order to prevent or minimize risks to the environment, making this particular very clear because of the impact it has on the very life of the human being an individual entity and as a social enti ty. In addition, it would modify in paragraph (5) of that Article the number of natural persons established to confirm and verify an odd number and in the specific cases of paragraph (4) in subparagraphs (d) and (e) it should be made clear that the int ervention can occur in real time, effectively ensuring that the AI system does not undermine human autonomy or cause adverse effects." 3123 3975 W3199976308.pdf 2 11 separator 0.9931778 ¶ 3977 3979 W3199976308.pdf 2 12 text 0.99884695 "Article 20 specifies that providers of high -risk AI systems shall keep log files for an appropriate period of time, and th is lawyer's criterion must be clearly defined, what that period of time would be" 3979 4188 W3199976308.pdf 2 0 text 0.9922155 "of these impurities before it is utilized by other plants within the steel works [ 6–8]." 0 90 W3215622922.pdf 1 1 separator 0.9742102 ¶ 90 92 W3215622922.pdf 1 2 text 0.9997212 "Throughout the steel production industry COG is uti- lized as an energy resource [ 3,5]. Due to the intricate operational nature of a steel works, COG production cannot always be matched to its utilization. As a result, COG pipelines comprise a bleeder to regulate pressure by flaringexcess supply. The downside of the bleeder is that con- tinuous flaring is required to prevent air from entering the pipeline and mix with the flammable gas [ 9]." 92 548 W3215622922.pdf 1 3 separator 0.9646812 ¶ 548 550 W3215622922.pdf 1 4 text 0.9994885 "This paper provides an industry case study of an in- depth data driven failure analysis regarding excessive gasbooster bearing failures at a COG pipeline station. Identi- fying the failure’s origin resulted in a structural mechanical design that prevents excessive future booster bearing fail-ures and station downtime. Furthermore, this allows the steel works to save on maintenance costs, and more importantly, yielding both improved energy utilizationthrough less COG wastages and overall safety." 550 1060 W3215622922.pdf 1 5 separator 0.99607146 ¶ 1060 1062 W3215622922.pdf 1 6 title 0.99028784 Problem Discussion 1062 1081 W3215622922.pdf 1 7 separator 0.99632573 ¶ 1081 1083 W3215622922.pdf 1 8 text 0.9978349 "For the steel works under consideration the discharge pressure at the COB is sufficient to reach all but two users. The one plant, which is near the COB, requires COG pressure above discharge. This plant comprises a gasbooster station to increase pressure and operates without bearing difficulties. The other user is the Hot Rolling Plant (HRP) that also makes use of a gas booster station; how-ever, a high frequency of bearing failures is observed." 1083 1542 W3215622922.pdf 1 9 separator 0.83702946 ¶ 1542 1544 W3215622922.pdf 1 10 text 0.99967456 "The HRP is connected to the COB by a two-kilometer pipeline, so that a halfway gas booster station is required toincrease the line pressure. This is to ensure that the COG line pressure at the HRP is above that of atmospheric conditions. At the HRP, thermal energy for production isacquired through combustion of COG with the addition of Natural Gas (NG) when required. Whereas COG is a by- product, NG is procured per volume." 1544 1981 W3215622922.pdf 1 11 separator 0.9593495 ¶ 1981 1983 W3215622922.pdf 1 12 text 0.9995151 "The halfway HRP gas booster station has two, 250 [kW], identical parallel rotating gas booster fans, from here on only referred to as boosters . Only one booster is oper- ated at a time, with the second serving as backup when failure occurs. The backup starts automatically upon fail- ure, or by manual switch-over during operations. Note,there is not a single booster dedicated as the primary or backup. The one in operation is by default the primary, and the other the backup. In theory the boosters should have noinfluence over the availability of COG at the HRP. This, however, is not the case." 1983 2597 W3215622922.pdf 1 13 separator 0.96616375 ¶ 2597 2599 W3215622922.pdf 1 14 text 0.99664116 "Excessive booster bearing failures have been experi- enced since commissioning more than two decades ago. Above average vibration levels are typically detectedduring normal plant operations, and it is not uncommon for the backup unit to fail with start-up, or within a few hours thereafter. As a result, there are times when both boosters simultaneously require bearing maintenance. During thesetimes the station’s main inlet valve closes, increasing both NG usage and COG flaring." 2599 3092 W3215622922.pdf 1 15 separator 0.7649939 ¶ 3092 3094 W3215622922.pdf 1 16 text 0.9986514 "It is important to note that the booster fan housings are sealed before both the drive and non-drive bearings. Therefore, neither of the bearings can be contaminated, or damaged, by the COG. Further note that all booster man- ufacturer and company protocols are followed during start- up, so that this event itself should not influence the integ-rity of the bearing." 3094 3470 W3215622922.pdf 1 17 separator 0.96994483 ¶ 3470 3472 W3215622922.pdf 1 18 text 0.99971676 "Throughout the previous two decades numerous root cause bearing failure analysis studies were undertaken.These studies followed scientifically based conventional failure analysis techniques; however, the root cause behind these frequent breakdowns could not be identified." 3472 3749 W3215622922.pdf 1 19 separator 0.99611545 ¶ 3749 3751 W3215622922.pdf 1 20 title 0.9917523 Data Acquisition for Analysis Purposes 3751 3790 W3215622922.pdf 1 21 separator 0.99530125 ¶ 3790 3792 W3215622922.pdf 1 22 text 0.99968284 "Performing a successful failure analysis requires adequate and relevant data. Data are acquired that potentially com-prise information, either directly or indirectly regarding the booster station. The data, to be discussed within this paper pertain to bearing pre-instalment, installation, operationaland process conditions that relate to the bearings, boosters, and COG. Following acquisition, the technical interpreta- tion of data is required to analyze the bearing failures." 3792 4281 W3215622922.pdf 1 23 separator 0.94863737 ¶ 4281 4283 W3215622922.pdf 1 24 text 0.9997308 "Identifying the significance of bearing failures is com- parable to the financial implication that results. From maintenance data it follows that the annual bearing main-tenance costs amount to US Dollar ($) 23,000. However, this is not the only financial implication as it was men- tioned earlier that booster station shutdowns result in bothincreased NG usages and COG flaring." 4283 4667 W3215622922.pdf 1 25 separator 0.936507 ¶ 4667 4669 W3215622922.pdf 1 26 text 0.99964255 "A data analysis model was formulated to solve for annual excess NG procurements. This thermodynamicmodel includes hourly energy usages, COG production and flaring rates, together with line pressures simulations. The details of this model, however, do not fall within the scopeof this paper. Modeling results indicate that excess annual NG procurements are in the proximity of $ 850,000." 4669 5063 W3215622922.pdf 1 27 separator 0.7269005 ¶ 5063 5065 W3215622922.pdf 1 28 text 0.99959373 Booster bearing failures, therefore, yield additional annualexpenses in the order of $ 873,000. 5065 5161 W3215622922.pdf 1 29 separator 0.76251465 ¶ 5161 5163 W3215622922.pdf 1 30 text 0.99949694 "Note that 97.4% of the financial impact from booster bearing failures is typically due to NG expenses. If thebearing failures are not reduced but could at least be pre- dicted in advance, so that preventive maintenance can occur, significant cost savings will be achieved. On-linecondition monitoring is a well-known engineering practice" 5163 5505 W3215622922.pdf 1 31 paratext 0.9792563 312 J Fail. Anal. and Preven. (2022) 22:311–318 5505 5552 W3215622922.pdf 1 32 separator 0.6311661 ¶ 5552 5554 W3215622922.pdf 1 33 paratext 0.98115885 123 5554 5558 W3215622922.pdf 1 0 paratext 0.95445716 REVIEWS AND ABSTRACTS 217 0 25 W2344864134.pdf 0 1 separator 0.99276984 ¶ 26 28 W2344864134.pdf 0 2 text 0.9976115 "pain, dependent upon the acuteness or chronicity of the process. The more common condition with which twisted cysts of the ovary may be confused are : twisted pedunculated fibroids ; interstitial hemorrhages in fibroid tumors; torsion of a hydrosalpinx; ectopic gestation; and acute appendicitis." 28 337 W2344864134.pdf 0 3 separator 0.8622087 ¶ 338 340 W2344864134.pdf 0 4 text 0.9963975 "Aimes finds the mortality to be about 7.6 per cent attributable more often to peritonitis than to hemorrhage, these two conditions being the complications of greatest danger. Palliative treatment may be ap- plied but the only curative treatment is the removal of the cystic mass by .operation. THEODORE W. ADAMS." 340 665 W2344864134.pdf 0 5 separator 0.9955393 ¶ 666 668 W2344864134.pdf 0 6 bibliography 0.9909085 "Dowxes: Tumors of the Ovary in Children. Journal American Medi- cal Association, 1921, lxxvi, 443." 668 770 W2344864134.pdf 0 7 separator 0.9868455 ¶ 771 773 W2344864134.pdf 0 8 text 0.98394734 "Eighty-six cases of ovarian tumors in girls 10 years and younger have been reported to date. A large number of these are malignant. Downes thinks they are frequently overlooked. He reports the success- ful removal of a simple cyst containing 2.5 liters of fluid from an infant 71,~ months of age in whom the condition had been mistaken for Hirschsprung’s disease. 12. E" 773 1158 W2344864134.pdf 0 9 bibliography 0.62404734 . 1158 1159 W2344864134.pdf 0 10 text 0.7226349 WOBUS 1159 1165 W2344864134.pdf 0 11 bibliography 0.42899475 . 1165 1166 W2344864134.pdf 0 12 separator 0.9948466 ¶ 1167 1169 W2344864134.pdf 0 13 bibliography 0.98554516 "Harley: A Gase of Ovarian Cyst of Unique Dimensions. Indian Med- ical Gazette, 1921, lvi, 18." 1169 1266 W2344864134.pdf 0 14 separator 0.98956317 ¶ 1267 1269 W2344864134.pdf 0 15 text 0.99914336 "Harley reports a case of ovarian cyst in a Hindu coolie, age 40, who gave a history of a small swelling in the lower abdomen gradually &creasing in size for fifteen years. Her menstruation was regular up to four months before seen. Slight dyspnea; heart displaced up- ward; slight edema of legs. Abdomen very large, skin stretched and thin, with veins in it very prominent. No distress on lying down." 1269 1685 W2344864134.pdf 0 16 separator 0.98483384 ¶ 1686 1688 W2344864134.pdf 0 17 table 0.7458138 "Circumference of abdomen 73’ inches. Urine normal and digestion good. Weight 246 lbs." 1688 1777 W2344864134.pdf 0 18 separator 0.9862573 ¶ 1778 1780 W2344864134.pdf 0 19 text 0.9924982 "She was operated on; an incision was made 30 inches long. The cyst was found adherent to the parietal peritoneum, bowels, diaphragm and liver. The round ligament was the size of a loop of small bowel. " 1780 1989 W2344864134.pdf 0 20 separator 0.5353251 ¶ 1989 1990 W2344864134.pdf 0 21 text 0.9972136 "The sac was isolated after considerable difficulty with very little bleed- ing and the patient seemed to stand operation very well. Weight of patient after operation 82 lbs. She died next day of shock due, ap- parently, to too much handling of peri-toneum. F. J. SOUBA." 1990 2269 W2344864134.pdf 0 22 separator 0.9953599 ¶ 2270 2272 W2344864134.pdf 0 23 bibliography 0.99330705 "J. Mason Hundley and Jack M. Hundley: A Report of Two Ovarian Cysts. Official Publication of the University of Maryland. Bulletin of the School of Medicine, 1921, v, 182." 2272 2449 W2344864134.pdf 0 24 separator 0.99348813 ¶ 2450 2452 W2344864134.pdf 0 25 text 0.98610675 "These cases are especially interesting because of the size of the cysts. In the first patient, a colored woman of 54 years, a cystadenoma of right ovary was found which weighed 102 pounds. During the removal of the cyst‘ one hundred pints of a greenish colored fluid were emptied. The patient (convalesced rapidly and left the hospital 14 days after the operation. The second case was a dermoid cyst weighing seventeen and one-half Ounces occurring in a colored child eighteen months of age. The child made an uneventful recovery following operation." 2452 3027 W2344864134.pdf 0 26 separator 0.9964652 ¶ 3028 3030 W2344864134.pdf 0 27 bibliography 0.639554 NORMAN F. MILLER. 3030 3048 W2344864134.pdf 0 0 title 0.9918951 Predisposing factors 0 20 W1965149071.pdf 5 1 separator 0.9963881 ¶ 20 22 W1965149071.pdf 5 2 text 0.9995166 "The indigents who benefited the most from the exemption cards were those over 69 years of age (p = 0.0001), singlepersons, and widows/widowers (p = 0.0001). Women and men received cards in nearly equal proportions." 22 241 W1965149071.pdf 5 3 separator 0.9969688 ¶ 241 243 W1965149071.pdf 5 4 title 0.9915665 Enabling factors 243 260 W1965149071.pdf 5 5 separator 0.99441683 ¶ 260 262 W1965149071.pdf 5 6 text 0.999676 "There was an association between all the enabling factors and the allocation of exemption cards. The indigents who received exemption cards were, in the majority of cases, those in the most disadvantaged situations. They werethose with no income-generating activity (p = 0.007), those who turned to sources outside of their household for food (p = 0.0001), those with no financial supportfrom their household for obtaining healthcare services (p = 0.002), and those who needed instrumental assist- ance in their activities of daily living but received nonefrom their entourage (p = 0.0001). Most of the indigents who received an exemption card belonged to households whose incomes corresponded to the second and thirdquintiles (p = 0.048). However, some indigents living in less seriously disadvantaged conditions than others also received exemption cards. These were people living witha spouse (p = 0.006), whereas very few of those living without a spouse and with children received cards." 262 1278 W1965149071.pdf 5 7 separator 0.99706054 ¶ 1278 1280 W1965149071.pdf 5 8 title 0.991124 Needs: health and functional disabilities 1280 1322 W1965149071.pdf 5 9 separator 0.9933523 ¶ 1322 1324 W1965149071.pdf 5 10 text 0.99359626 "The probability of receiving a card was higher among those presenting health needs. These were persons withchronic illnesses (p = 0.024), with visual impairments (p = 0.0001), and/or with physical disabilities in terms of mo- bility (p = 0.004) and muscle strength (p = 0.0001). Furthermore, card allocation was not associated with healthcare service use in the preceding six months." 1324 1718 W1965149071.pdf 5 11 separator 0.9964307 ¶ 1718 1720 W1965149071.pdf 5 12 title 0.9885254 Needs: by sex 1720 1734 W1965149071.pdf 5 13 separator 0.9914187 ¶ 1734 1736 W1965149071.pdf 5 14 text 0.999648 "The groups receiving exemption cards were the same among men and women, except in the case of fine finger move-ment limitations, where women received more." 1736 1894 W1965149071.pdf 5 15 separator 0.9968159 ¶ 1894 1896 W1965149071.pdf 5 16 title 0.9915482 Multivariate analysis 1896 1918 W1965149071.pdf 5 17 separator 0.99534905 ¶ 1918 1920 W1965149071.pdf 5 18 text 0.99906874 "The adjusted odds ratios (OR) for the factors associated with the allocation of exemption cards to indigents are presented in Table 2." 1920 2059 W1965149071.pdf 5 19 separator 0.9270308 ¶ 2059 2061 W1965149071.pdf 5 20 text 0.99947244 "The allocation of exemption cards was significantly as- sociated with widowed marital status (OR = 1.40; CI 95% [1.10 –1.78]), with not receiving financial assistance from within the household to obtain healthcare services (OR = 1.58; CI 95% [1.26 –1.97]), and with living alone (OR = 1.28; CI 95% [1.01 –1.63]) or cohabiting with a spouse (with or without children) (OR = 2.00; CI 95% [1.35 –2.96]). The same was true for indigents with vision impairments (OR = 1.45 CI 95% [1.14 –1.84]) and thosewith good mobility and poor muscle strength (OR = 1.73; CI 95% [1.28 –2.33])." 2061 2655 W1965149071.pdf 5 21 separator 0.77768004 ¶ 2655 2657 W1965149071.pdf 5 22 text 0.99872476 "The allocation of cards was not associated with age, with needing instrumental assistance with activities of daily liv- ing, with self-reported chronic illnesses, or with prior use of healthcare services." 2657 2868 W1965149071.pdf 5 23 separator 0.99627924 ¶ 2868 2870 W1965149071.pdf 5 24 title 0.9895432 Discussion 2870 2881 W1965149071.pdf 5 25 separator 0.9964894 ¶ 2881 2883 W1965149071.pdf 5 26 text 0.999695 "This study showed that the indigents selected by COGESsto receive exemption cards were, for the most part, those living in the most disadvantaged conditions. They were widows/widowers, those without financial assistance fromtheir household to obtain care, those living alone, and those with vision impairments. The indigents selected by COGESs who lived in less seriously disadvantaged condi-tions than others and still received the card were mostly those living with their spouses and those with poor muscle strength and good mobility. That being said, the resultsoverall showed that it was the indigents selected by the COGESs who were living in the most extremely dis- advantaged conditions who benefited from the exemp-tion program." 2883 3636 W1965149071.pdf 5 27 separator 0.9968844 ¶ 3636 3638 W1965149071.pdf 5 28 title 0.9888055 The most vulnerable indigents were selected by COGESs 3638 3692 W1965149071.pdf 5 29 separator 0.99074686 ¶ 3692 3694 W1965149071.pdf 5 30 text 0.9997015 "An indigent person ’s inability to receive financial assist- ance from his or her household to obtain care reflects the financial difficulties of that household. This meansthe indigents selected by COGESs to receive the cards were those living in households with the fewest financial resources. These results are consistent with a study doneon a smaller scale in the same region, in which the se- lected indigents were those whose households had the fewest financial and material resources [14]. A study con-ducted in Ghana in 2010, in which household well-being was considered in indigent selection, was not effective in identifying the most disadvantaged in regions where thepoverty rate is high [16]. On the other hand, an evaluation conducted in the Nouna region of Burkina Faso showed that a selection process similar to the one used in Ghanawas able to target the most vulnerable indigents [6]." 3694 4615 W1965149071.pdf 5 31 separator 0.9749919 ¶ 4615 4617 W1965149071.pdf 5 32 text 0.99966216 "The greatest beneficiaries of the exemption cards allo- cated by the COGESs were widows and widowers. Thisresult is also consistent with the smaller-scale study done in the same district [14]. This is an equitable aspect of this selection method. In fact, widowed persons are more vul-nerable than others, especially if they are elderly, as in the present study. In previous studies, criteria related to mari- tal status were not used in indigent selection. The fact thatmost indigents living alone were also selected by COGESs is in keeping with this line of thinking. Isolation is a nega- tive factor for mental health. Persons living in isolationoften have limited moral support and receive little assist- ance in activities of daily living. They are also more in- clined to have precarious mental health [26-29]. They are" 4617 5461 W1965149071.pdf 5 33 paratext 0.9833354 Atchessi et al. BMC Public Health 2014, 14:1158 Page 6 of 10 5461 5521 W1965149071.pdf 5 34 separator 0.53770137 5521 5522 W1965149071.pdf 5 35 paratext 0.95444643 ¶ http://www.biomedcentral.com/1471-2458/14/1158 5522 5570 W1965149071.pdf 5 0 caption 0.99500465 Figure 3. Comparison of Ellipsys3D and OpenFoam for the wake of a single turbine in laminar 0 91 W1995709278.pdf 8 1 separator 0.9002395 ¶ 91 93 W1995709278.pdf 8 2 caption 0.9566855 "ow, with a Dynamic Smagorinsky sub-grid scale model. (a) streamwise velocity, (b) hu0u0i=U2 o, (c) Eddy viscosity ratio." 94 219 W1995709278.pdf 8 3 separator 0.993978 ¶ 219 221 W1995709278.pdf 8 4 paratext 0.87845546 The Science of Making Torque from Wind 2014 (TORQUE 2014) IOP Publishing 221 294 W1995709278.pdf 8 5 separator 0.55640596 294 295 W1995709278.pdf 8 6 paratext 0.961019 ¶ Journal of Physics: Conference Series 524(2014) 012145 doi:10.1088/1742-6596/524/1/012145 295 386 W1995709278.pdf 8 7 separator 0.9790611 ¶ 386 388 W1995709278.pdf 8 8 paratext 0.94279766 7 388 390 W1995709278.pdf 8 0 text 0.9968152 "Strong correlations were observed between staining for CCK or for NK-1R and individual rat responses on all cold tests (acetone, cold plate events, duration andlatency and thermal preference (0°C vs. 45°C) cold timeand crossovers). MOR and NPY did not demonstratesignificant correlations with any of the cold behavioursat 45 days postoperatively." 0 350 W1990090352.pdf 6 1 separator 0.9965762 ¶ 350 352 W1990090352.pdf 6 2 title 0.98616076 Discussion 352 363 W1990090352.pdf 6 3 separator 0.99614805 ¶ 363 365 W1990090352.pdf 6 4 text 0.9993677 "The key findings in the present study are: 1 - SpragueDawley rats subjected to bCCI show prolonged increasein sensitivity to cold stimuli; 2 - enhanced sensitivity tomechanical stimulation is transient in the same bCCIrats that showed persistently enhanced cold sensitivitylong after recovery of mechanical sensitivity; and 3 -superficial dorsal horn staining for MOR and NPY pep- tide are not significantly correlated to behavioural responses to cold stimuli, while CCK-8 and NK-1R weresignificantly correlated at 45 days. The results of thepresent study provide evidence that responses to coldstimuli, both reflex and operant responses, are morerobust and long lasting than reflex withdrawal responsesto mechanical probing in the bCCI model and furthersuggest that the usefulness of the CCI as a model of neuropathically altered pain sensitivity may be enhanced by use of bilateral lesions coupled with analysis ofresponses to cold stimuli, particularly operant responses.In the present study, bCCI did not produce evidence ofspontaneous pain behaviours, either in home cages orduring evoked pain testing." 365 1481 W1990090352.pdf 6 5 separator 0.9962128 ¶ 1481 1483 W1990090352.pdf 6 6 caption 0.9651662 "Figure 6 Superficial dorsal horn immunohistochemical staining for CCK . (A) Representative photomicrographs of dorsal horn immunoreactivity for cholecystokinin (CCK) in sham operated rats (Sham CCK) versus bCCI rats on post-ligation day 15. Scale bar represents 100μM. Medial area of the dorsal horn shows greatest decrease in staining in bCCI rats compared to sham-operated controls. (B) Dorsal horn CCK staining densitometry at various postoperative days compared as a percentage of" 1483 1972 W1990090352.pdf 6 7 text 0.5967597 staining 1972 1981 W1990090352.pdf 6 8 caption 0.4876671 in 1981 1984 W1990090352.pdf 6 9 text 0.65066487 na 1984 1987 W1990090352.pdf 6 10 caption 0.59378356 ï 1987 1988 W1990090352.pdf 6 11 text 0.97791636 "ve rats. CCK peptide staining decreased at all the time points studied (p < 0.001; F = 68.3; df = 1; Two way ANOVA). CCK -8 showed decrease in immunoreactivity in day 15 (p = 0.001; post hoc Tukey Test) followed by a slight increase at day 30 (p = 0.02; post hoc Tukey test) and then a marked and consistent decrease thereafter today 90 compared to sham operated rats (p < 0.001; post hoc Tukey test). Data points are group" 1988 2415 W1990090352.pdf 6 12 caption 0.54586923 2415 2416 W1990090352.pdf 6 13 text 0.5709081 means 2416 2421 W1990090352.pdf 6 14 caption 0.5477103 2421 2422 W1990090352.pdf 6 15 text 0.55038893 +/- SEM 2422 2429 W1990090352.pdf 6 16 caption 0.41471043 .D 2429 2431 W1990090352.pdf 6 17 paratext 0.80231017 atta et al .Molecular Pain 2010, 6:7 2431 2467 W1990090352.pdf 6 18 separator 0.8618368 ¶ 2467 2469 W1990090352.pdf 6 19 paratext 0.98849726 http://www.molecularpain.com/content/6/1/7Page 7 of 16 2469 2524 W1990090352.pdf 6 0 paratext 0.9644598 Two complete mitochondrial genomes from Praticolella mexicana Perez, 2011...139 0 80 W2532913370.pdf 2 1 separator 0.9960806 ¶ 80 82 W2532913370.pdf 2 2 caption 0.9940728 "Figure 1. Mitochondrial genome of Praticolella mexicana UTRGV and McAllen illustrated with an im - age of the species holotype (ANSP 426031). Gene order and sizes are shown relative to one another, not including non-coding regions. Genes are color coded by H (black) or L (red) strand. IUPAC single letter codes are used to identify tRNA genes." 82 437 W2532913370.pdf 2 3 separator 0.93204296 ¶ 437 439 W2532913370.pdf 2 4 text 0.98773557 "explore gene order evolution in Helicoidea. Results from both aspects of the study will increase our knowledge of these gastropod groups and provide a better understanding of land snail mitochondrial genome evolution." 439 663 W2532913370.pdf 2 5 separator 0.99617696 ¶ 663 665 W2532913370.pdf 2 6 title 0.98621154 Materials and methods 665 687 W2532913370.pdf 2 7 separator 0.9948454 ¶ 687 689 W2532913370.pdf 2 8 title 0.96016264 Specimen collection and DNA extraction 689 728 W2532913370.pdf 2 9 separator 0.99253774 ¶ 728 730 W2532913370.pdf 2 10 text 0.9895738 "We collected one adult P . mexicana each from the UTRGV campus in Edinburg, Texas (26.30726; -98.1714), and from a residential neighborhood in McAllen, Texas" 730 891 W2532913370.pdf 2 0 paratext 0.9887853 64 Page 12 of 30 J.-W. van Ittersum et al. 0 42 W3179072787.pdf 11 1 separator 0.99072117 ¶ 42 44 W3179072787.pdf 11 2 text 0.99699336 "for all m∈Z,n<0. We then have that G(m,n+1)−G(m,n)=f(n,m−n) is a polynomial for all m,n.B u t P(m,n+1)−P(m,n)is also a polynomial. The two polynomials agree for n>0, so they agree for all n; since Gand Palso agree forn>0, this means that they must also agree for all n." 44 320 W3179072787.pdf 11 3 separator 0.7048531 ¶ 320 322 W3179072787.pdf 11 4 text 0.9478043 "The lemma now follows, since it is just saying that F(−n)=P(−n,−n)= G(−n,−n)." 322 402 W3179072787.pdf 11 5 math 0.5924827 / 402 404 W3179072787.pdf 11 6 text 0.6458489 intersections 404 417 W3179072787.pdf 11 7 math 0.63933545 q/ 417 419 W3179072787.pdf 11 8 text 0.60059804 unions 419 425 W3179072787.pdf 11 9 math 0.6853446 q 425 426 W3179072787.pdf 11 10 separator 0.9298841 ¶ 426 428 W3179072787.pdf 11 11 text 0.88977087 "We also will find the following language convenient: we say that a set of power series fm(z)∈R[[z]],m∈Zfor some coefficient ring Rispolynomial in m if there exist polynomials Pk(u)∈R[u]such that " 428 628 W3179072787.pdf 11 12 math 0.55373836 ∀m∈ 628 631 W3179072787.pdf 11 13 text 0.50757366 Z 631 632 W3179072787.pdf 11 14 math 0.5283543 :fm(z)=/ 632 640 W3179072787.pdf 11 15 text 0.5984122 summationdisplay 640 656 W3179072787.pdf 11 16 math 0.59109896 ¶ k≥0Pk(m)zk 656 669 W3179072787.pdf 11 17 text 0.59651405 . 669 670 W3179072787.pdf 11 18 separator 0.7563343 ¶ 670 672 W3179072787.pdf 11 19 text 0.9922769 In our case the coefficient ring Rwill usually be the ring of quasi-modular forms QMod . 672 760 W3179072787.pdf 11 20 separator 0.99666506 ¶ 760 762 W3179072787.pdf 11 21 title 0.9915216 3 Differentialequation 762 784 W3179072787.pdf 11 22 separator 0.99653274 ¶ 784 786 W3179072787.pdf 11 23 text 0.94631886 "In this section we study the function φmdefined by the differential equation ( 1) and the constant term φm=pm/2−p−m/2+O(q). We first prove the evaluation φm=Res x=0/parenleftbigg/Theta1(x+z) /Theta1(x)/parenrightbiggm which immediately implies that φmis a quasi-Jacobi form. We then study the Fourier expansion of φm, discuss the dependence of φmon the parameter m, and derive a holomorphic anomaly equation." 786 1205 W3179072787.pdf 11 24 separator 0.9963211 ¶ 1205 1207 W3179072787.pdf 11 25 title 0.9917127 3.1 Proof of Theorem 1.2 1207 1232 W3179072787.pdf 11 26 separator 0.9959538 ¶ 1232 1234 W3179072787.pdf 11 27 text 0.939372 Define functions φm,m≥0 by the claim of the theorem i.e. let φm 1234 1297 W3179072787.pdf 11 28 math 0.5019856 = 1297 1298 W3179072787.pdf 11 29 text 0.5253297 ¶ 1298 1300 W3179072787.pdf 11 30 math 0.5904693 Res x=0/par 1300 1312 W3179072787.pdf 11 31 text 0.49591643 en 1312 1314 W3179072787.pdf 11 32 math 0.6227611 "leftBig /Theta1(x+z) ¶" 1314 1338 W3179072787.pdf 11 33 text 0.53126854 1338 1339 W3179072787.pdf 11 34 math 0.6114385 /Theta1(x)/parenrightBig 1339 1363 W3179072787.pdf 11 35 text 0.95897186 "m . We need to check that these function satisfy the differential equations ( 1) and have the right constant term ( 2). Checking the constant term is straightforward and we omit the details (see also Sect. 3.2). To check the differential equation we form the generating series g(y)=/summationtext m≥1ymφ" 1363 1676 W3179072787.pdf 11 36 math 0.51163846 m/m 1676 1679 W3179072787.pdf 11 37 text 0.7346845 . Let also Dy=y 1679 1694 W3179072787.pdf 11 38 math 0.5394607 d 1694 1695 W3179072787.pdf 11 39 text 0.45445907 ¶ 1695 1697 W3179072787.pdf 11 40 math 0.6544306 dy 1697 1700 W3179072787.pdf 11 41 text 0.8008269 . 1700 1701 W3179072787.pdf 11 42 separator 0.6223444 ¶ 1701 1703 W3179072787.pdf 11 43 text 0.8960108 "The differential equation ( 1) is then equivalent to D" 1703 1760 W3179072787.pdf 11 44 math 0.83444625 "2 τg(y)=F(z,τ)D2 yg(y). (11)" 1760 1792 W3179072787.pdf 11 45 separator 0.8504743 ¶ 1792 1794 W3179072787.pdf 11 46 text 0.6371432 Consider the function f(x)= 1794 1822 W3179072787.pdf 11 47 math 0.48485678 / 1822 1823 W3179072787.pdf 11 48 text 0.6957276 "Theta1(x+z) /Theta1(x)and apply the variable change" 1823 1876 W3179072787.pdf 11 49 math 0.54647577 ¶ y=1 1876 1882 W3179072787.pdf 11 50 separator 0.45969978 ¶ 1882 1884 W3179072787.pdf 11 51 math 0.635963 f(x)⇐⇒ x=g(y) 1884 1898 W3179072787.pdf 11 0 paratext 0.97212726 rap — r io de Janeiro 44(6):1379-1404, noV./deZ. 20101390 É 0 59 W2013835314.pdf 11 1 contact 0.7588084 rico Veras Marques • Marco aurÉlio Machado 59 101 W2013835314.pdf 11 2 separator 0.9936011 ¶ 101 103 W2013835314.pdf 11 3 text 0.99784416 "copo deste primeiro painel, os especialistas são definidos como consultores ou gestores de trânsito do estado do Ceará. O pesquisador buscou especialistas que representassem os órgãos executivos de trânsito municipais e estaduais." 103 340 W2013835314.pdf 11 4 separator 0.74349165 ¶ 341 343 W2013835314.pdf 11 5 text 0.99789935 "Os entrevistados fazem ou fizeram parte das seguintes instituições: Detran — Órgão Executivo de Trânsito do Estado do Ceará, DER — Órgão Executivo Rodoviário do Estado do Ceará e AMC — Órgão Executivo de Trânsito Mu - nicipal da cidade de Fortaleza. Todos os especialistas são mestres na área de trânsito ou transporte e com um bom conhecimento sobre tomada de decisão." 343 724 W2013835314.pdf 11 6 separator 0.726441 ¶ 725 727 W2013835314.pdf 11 7 text 0.9978633 "Cada entrevista durou, em média, 120 minutos e foram realizadas conforme cronograma pré-estabelecido pelo pesquisador." 727 849 W2013835314.pdf 11 8 separator 0.9670725 ¶ 849 851 W2013835314.pdf 11 9 text 0.9988458 "O principal foco do primeiro painel de especialistas foi o de formatar as entrevistas estruturadas a serem feitas junto aos especialistas do segundo painel e também formatar o questionário a ser aplicado junto aos gestores dos órgãos executivos de trânsito das capitais brasileiras." 851 1143 W2013835314.pdf 11 10 separator 0.97649884 ¶ 1143 1145 W2013835314.pdf 11 11 text 0.999482 "Todos os especialistas que compõem o primeiro painel possuem mestra - do na área de engenharia de transportes. Os especialistas ocupam ou ocupa - ram cargos de diretoria em órgãos executivos de trânsito rodoviário, estadual e municipal, no estado do Ceará. O conhecimento dos especialistas na área de trânsito é indiscutível e os mesmos participam de educação continuada nessa área. Quanto ao conhecimento na área de tomada de decisão, pode-se enqua - drar os especialistas como decisores que possuem conhecimento acadêmico sobre o tema, mas que não têm uma leitura aprofundada sobre o mesmo." 1145 1756 W2013835314.pdf 11 12 separator 0.9766967 ¶ 1756 1758 W2013835314.pdf 11 13 text 0.99914587 "A primeira rodada de entrevistas da fase inicial foi pautada em cima de perguntas abertas e buscou a opinião pessoal de cada um dos especialistas do primeiro painel sobre a exequibilidade da pesquisa e, principalmente, sobre a validação das questões referentes ao referencial teórico, com dois objetivos específicos: estruturar as entrevistas junto aos especialistas do segundo painel e estruturar o questionário a ser aplicado junto aos gestores dos órgãos execu - tivos de trânsito das capitais brasileiras." 1758 2285 W2013835314.pdf 11 14 separator 0.90920126 ¶ 2285 2287 W2013835314.pdf 11 15 text 0.9993951 "Os três especialistas foram unânimes em responder afirmativamente quando perguntados sobre a exequibilidade da pesquisa, e foram além, infor - mando ainda que a área de estudo sobre trânsito não possuía cientificamente nada a respeito do tema e que o estudo seria de grande valia para o setor. Na visão dos especialistas, um trânsito seguro pode ser medido tomando-se por base a taxa de mortalidade, ou seja, quantidade de mortos por 10 mil veículos ou quantidade de mortos por 100 mil habitantes." 2287 2802 W2013835314.pdf 11 16 separator 0.85261244 ¶ 2802 2804 W2013835314.pdf 11 17 text 0.9994157 "Segundo os especialistas, é possível definir-se um modelo de decisão que auxilie na aplicação dos recursos arrecadados de um órgão executivo de trânsito, porém, apenas o modelo não garante um trânsito seguro. Ainda para" 2804 3030 W2013835314.pdf 11 0 paratext 0.9061781 ResearchArticle 0 15 W2766677791.pdf 0 1 separator 0.7841563 ¶ 15 17 W2766677791.pdf 0 2 title 0.9817406 "Influence of Digestion Procedure and Residual Carbon on Manganese, Copper, and Zinc Determination in Herbal Matricesby Atomic Absorption Spectrometry" 17 169 W2766677791.pdf 0 3 separator 0.9912501 ¶ 169 171 W2766677791.pdf 0 4 contact 0.98675156 "Dorota Adamczyk-Szabela, Piotr Anielak, and Wojciech M. Wolf InstituteofGeneralandEcologicalChemistry,LodzUniversityofTechnology,Zeromskiego116,90-924Lodz,Poland" 171 335 W2766677791.pdf 0 5 separator 0.8019321 ¶ 335 337 W2766677791.pdf 0 6 contact 0.9935571 CorrespondenceshouldbeaddressedtoDorotaA damczyk-Szabela;dorota.adamczyk@p.lodz.pl 337 420 W2766677791.pdf 0 7 separator 0.9263135 ¶ 420 422 W2766677791.pdf 0 8 paratext 0.97862875 Received 4 May 2017; Revised 26 July 2017; Accepted 7 September 2017; Published 18 October 2017 422 518 W2766677791.pdf 0 9 separator 0.61827576 ¶ 518 520 W2766677791.pdf 0 10 contact 0.8073737 "Academic Editor:KrystynaPyrzynska" 520 556 W2766677791.pdf 0 11 separator 0.63870776 ¶ 556 558 W2766677791.pdf 0 12 paratext 0.9705403 "Copyright © 2017 DorotaAdamczyk-Szabelaetal. This is an open access article distributed under the Creative Commons AttributionLicense,whichpermitsunrestricteduse,distributio n,andreproductioninanymedium,providedtheoriginalworkis properlycited." 558 806 W2766677791.pdf 0 13 separator 0.9939113 ¶ 806 808 W2766677791.pdf 0 14 text 0.99927574 "Mineralizationtothecompleteoxidationofsamplecarboncomponentdoesnotalwaysassurethebestanalyterecovery.Particular attentionshouldbepaidtothepresenceofsiliconintheinvestigatedplantsampleandespeciallyinthecertifiedreferencematerial forwhichSicontentisscarcelygivenbytheproviders.Duringmineralizationwithoutadditionofthehydrofluoricacid,theresidualcarbon may block silica surfaces and increase availability of an analyte for its spectral determination in the solution. This issue is ofparticularrelevancebecausestandardprotocolsfordigestionofplantmatricesoftendonotsupporthydrofluoricacidaddition." 808 1407 W2766677791.pdf 0 15 separator 0.932953 ¶ 1407 1409 W2766677791.pdf 0 16 text 0.9918417 "Severalproceduresrecommendedfordecompositionofherbalplantswereappliedfortherespectivecertifiedreferencematerialandexaminedindetail.Manganese,copper,andzinccontentswereanalyzedinallsamplesbytheflameatomicabsorptionspectrometry. Additionally, the residual carbon was determined in all mineralizates. Silicon content was analyzed by the X-ray fluorescence method.Thebestrecoverieswereobservedforsamplescharacterizedbyrelativelyhighresidualcarbon." 1409 1857 W2766677791.pdf 0 17 separator 0.9971882 ¶ 1857 1859 W2766677791.pdf 0 18 title 0.9821061 1. Introduction 1859 1875 W2766677791.pdf 0 19 separator 0.99339354 ¶ 1875 1877 W2766677791.pdf 0 20 text 0.99855953 "Accurate determination of heavy metals content in medical herbs and herbal food additives is an important issue inapplied analytical chemistry and agriculture [1]. MedicinalplantsarewidelyusedallovertheworldandaccordingtotheWorldHealthOrganization(WHO)theyarethemainsourceof health care for millions of people. Their consumption isgrowing worldwide in developing and developed countriesalike.Herbaltherapiesareusuallylongterm.Therefore,evensmall heavy metal doses as present in particular plant mayaccumulate in patient body over a period of time. Thisissue prompted numerous works on analytical proceduresfor metal determination in medical herbs and herbal foodsupplements. However, papers critically evaluating samplepreparationstepsanddigestionarequitescarceindeed[2]." 1877 2651 W2766677791.pdf 0 21 separator 0.65121245 ¶ 2651 2653 W2766677791.pdf 0 22 text 0.9991831 "Modern spectral methods, like AAS or ICP, widely appliedfortheheavymetaldeterminationinenvironmentalsamplesrequireefficientmatrixdestruction[3,4].Foryears,analytical chemists have been aiming at developing effectivemethodsofmineralization." 2653 2895 W2766677791.pdf 0 23 separator 0.8566626 ¶ 2895 2897 W2766677791.pdf 0 24 text 0.9990613 "Organic or mixed samples are usually brought into solution by some types of oxidation process followed byan acid digestion of the resulting residue. In dry ashingprocedures,theorganicma tterofasam pleisdecom poseda thightemperaturesandresultingashissubsequentlydissolvedin a strong acid [5]. Usually, mineralization is performedat atmospheric pressure in a programmable furnace attemperatures approaching the range 450–600 ∘C [6]. The importantpracticaladvantageofthismethodisthatitallowsprocessing relatively large samples. The resulting ash can beeasily dissolved in a small volume of acid enabling efficientpreconcentration of trace elements in the final solution [7].As compared to dry ashing, the wet digestion applies sig-nificantly wider range of reagents and methodologies [8]. Itmaybecarriedoutinopenorclosedsystems,thelatterbeingespeciallyrecommendedfortraceanalysis.Thebreakthroughinmodernmineralizationtechniquescamewithintroduction" 2897 3848 W2766677791.pdf 0 25 separator 0.98441327 ¶ 3848 3850 W2766677791.pdf 0 26 paratext 0.94578946 "Hindawi Journal of Analytical Methods in Chemistry Volume 2017, Article ID 6947376, 10 pages https://doi.org/10.1155/2017/6947376" 3850 3986 W2766677791.pdf 0 0 paratext 0.9484907 "1658 Journal of Material Cycles and Waste Management (2018) 20:1648–1662 1 3" 0 78 W2800188596.pdf 10 1 separator 0.99390423 ¶ 78 80 W2800188596.pdf 10 2 text 0.95228255 "The methods chosen to survey the geological structure in the three profiles are based on the conductivity, resistivity, and dielectric constant of the geological environment." 80 258 W2800188596.pdf 10 3 separator 0.92412645 ¶ 258 260 W2800188596.pdf 10 4 text 0.99700075 "When comparing the map of equipotential based on the self-potential (SP) data carried out on March 2015 (Fig. 3a) and the equivalent map for March 2016 (Fig. 3b) we can see very clearly the negative differences in the quantity, magni-tude, as well as, overarching scope related to the location of the SP anomalies. The location of the anomaly peak SP in 2016 changed only slightly in comparison to the year 2015, but the amplitude of the anomalies changed significantly which points to the negative anomalies which appeared in large numbers nearby the landfill. This was confirmed by the results of the analysis of the quality of the surface- and groundwater." 260 931 W2800188596.pdf 10 5 separator 0.98966753 ¶ 931 933 W2800188596.pdf 10 6 text 0.9383998 "The model of the electrical resistivity tomographic pro- files T1(A), T2(A) and T3(A) in March 2015 (Fig. 4) and the profiles T1(B), T2(B) and T3(B) in March 2016 (Fig. 5)" 933 1112 W2800188596.pdf 10 7 separator 0.6558981 ¶ 1113 1115 W2800188596.pdf 10 8 text 0.99947566 "showed apparent difference in the resistivity values reaching as far as ca. 50 m deep below the ground surface. The inves-tigation revealed that the geological structure is highly inho - mogeneous vertically, but fairly homogeneous horizontally. As a result we can observe here good conditions for ground-water run-off, the formation of the lens containing water and different sediments." 1115 1505 W2800188596.pdf 10 9 separator 0.9772124 ¶ 1505 1507 W2800188596.pdf 10 10 text 0.9995758 "The VLF-EM results mapped the shallow linear con- ductors that are probably the fractured/saturated zones of varying length in the area which is of significant hydrogeo-logic importance for groundwater bearing. Interpretations are based on the high amplitude signal, which suggests the presence of weathered or fractured zones. The analysis of the VLF data by in-phase component was used to delineate the source and depth to the top of a subsurface conductive body. The amplitude of the analytical signal of the data showed the location of the anomalous body. The anomaly observed in the VLF survey is also associated to the deviation of the measured signal from the regular level, and this deviation is a result of the response of the subsurface geological objects" 1507 2275 W2800188596.pdf 10 11 title 0.98622835 Table 1 Results of surface water analysis by the Institute of Chemistry and the Institute of Geophysics, VAST 2275 2386 W2800188596.pdf 10 12 separator 0.8813162 ¶ 2386 2388 W2800188596.pdf 10 13 title 0.97997993 a QCVN-08-MT (B1) 2015: Vietnam Technical Regulation on surface water quality by the Ministry of Natural Resources and Environment 2388 2519 W2800188596.pdf 10 14 separator 0.9625732 ¶ 2520 2522 W2800188596.pdf 10 15 table 0.99191135 "(MONRE)No. Parameters Units Name of samples and content for date Standard QCVN-08-MT(B1) 2015 a N1 N3 N5 Mar. 24, 2015Mar. 26, 2016Mar. 24, 2015Mar. 26, 2016Mar. 24, 2015Mar. 26, 2016 1 pH mg/l 7.95 7.68 7.78 7.89 7.72 7.75 5.5–9.0 2 DO mg/l 2.9 3.2 3.9 3.8 2.8 2.6 ≥ 4 3 TSS mg/l 98 87 32 30 26 37 50 4 COD mg/l 233 278 401 444 540 556 30 5 BOD 5 mg/l 196 202 312 337 341 356 15 6 NH4+mg/l 11.5 18.7 21.0 22.7 19.4 20.3 0.9 7 NO2−mg/l 0.12 0.20 0.46 0.53 1.02 0.96 0.05 8 NO3−mg/l 3.6 5.2 8.7 9.4 15.6 16.8 10 9 Cyanide (CN−)mg/l 0.04 0.05 0.08 0.10 0.12 0.13 0.05 10 Arsenic (As) mg/l 0.08 0.08 0.15 0.15 0.14 0.17 0.05 11 Cadmium (Cd)mg/l 0.03 0.06 0.09 0.08 0.12 0.13 0.01 12 Lead (Pb) mg/l 0.05 0.06 0.16 0.17 0.22 0.24 0.05 13 Copper (Cu) mg/l 0.8 0.9 1.2 1.3 1.6 1.9 0.5 14 PO43−mg/l 0.27 0.56 1.00 1.12 1.12 1.24 0.3 15 Iron (Fe) mg/l 1.77 1.90 1.45 1.88 1.89 2.03 1.5 16 Total N mg/l 23.6 25.7 39.8 43.3 42.7 55.8 – 17 Total P mg/l 2.05 2.06 3.56 3.89 4.07 5.55 – 18 Coliform MPN/100 ml 9800 10,500 10,700 11,000 11,600 12,800 7500 19 E.-coli MPN/100 ml 400 500 500 600 500 600 100 20 EC mS/m 25.8 33.7 117.8 130.2 102.6 136.5 21 TemperatureoC 23.4 22.7 22.7 23.1 23.3 22.8 22 TDS ppm 234 267 389 390 443 456" 2522 3801 W2800188596.pdf 10 0 paratext 0.68389523 Papers 0 6 W2151373895.pdf 1 1 separator 0.8691368 ¶ 6 8 W2151373895.pdf 1 2 title 0.9372106 "Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study" 8 118 W2151373895.pdf 1 3 separator 0.9610467 ¶ 118 120 W2151373895.pdf 1 4 contact 0.5057874 Ka He, Anwar Merchant, Eric B Rimm, Bernard A Rosner, Meir J Stampfer, Walter C Willett 120 208 W2151373895.pdf 1 5 paratext 0.47948048 , 208 209 W2151373895.pdf 1 6 contact 0.3566207 209 210 W2151373895.pdf 1 7 paratext 0.41564816 ¶ 210 212 W2151373895.pdf 1 8 contact 0.501887 Alberto Asche 212 225 W2151373895.pdf 1 9 paratext 0.47292593 rio 225 228 W2151373895.pdf 1 10 separator 0.98721164 ¶ 228 230 W2151373895.pdf 1 11 title 0.9018871 Abstract 230 239 W2151373895.pdf 1 12 separator 0.988135 ¶ 239 241 W2151373895.pdf 1 13 text 0.9971906 "Objective T o examine the association between intake of total fat, specific types of fat, and cholesterol andrisk of stroke in men.Design and setting Health professional follow up study with 14 year follow up.Participants 43 732 men aged 40-75 years who were free from cardiovascular diseases and diabetes in 1986.Main outcome measure Relative risk of ischaemic and haemorrhagic stroke according to intake of totalfat, cholesterol, and specific types of fat.Results During the 14 year follow up 725 cases of stroke occurred, including 455 ischaemic strokes, 125haemorrhagic stokes, and 145 strokes of unknowntype. After adjustment for age, smoking, and otherpotential confounders, no evidence was found thatthe amount or type of dietary fat affects the risk ofdeveloping ischaemic or haemorrhagic stroke.Comparing the highest fifth of intake with the lowestfifth, the multivariate relative risk of ischaemic strokewas 0.91 (95% confidence interval 0.65 to 1.28; P fortrend = 0.77) for total fat, 1.20 (0.84 to 1.70; P = 0.47)for animal fat, 1.07 (0.77 to 1.47; P = 0.66) forvegetable fat, 1.16 (0.81 to 1.65; P = 0.59) for saturatedfat, 0.91 (0.65 to 1.28; P = 0.83) for monounsaturatedfat, 0.88 (0.64 to 1.21; P = 0.25) for polyunsaturatedfat, 0.87 (0.62 to 1.22; P = 0.42) for trans unsaturated fat, and 1.02 (0.75 to 1.39; P = 0.99) for dietarycholesterol. Intakes of red meats, high fat dairyproducts, nuts, and eggs were also not appreciablyrelated to risk of stroke.Conclusions These findings do not support associations between intake of total fat, cholesterol, orspecific types of fat and risk of stroke in men." 241 1875 W2151373895.pdf 1 14 separator 0.99696636 ¶ 1875 1877 W2151373895.pdf 1 15 title 0.9251095 Introduction 1877 1890 W2151373895.pdf 1 16 separator 0.9955739 ¶ 1890 1892 W2151373895.pdf 1 17 text 0.99958754 "Strong evidence indicates that type of dietary fat ismore important than total fat intake in predicting riskof coronary heart disease, as different types of fat orfatty acids may play different or opposite roles.Monounsaturated and polyunsaturated fats seem tohave beneficial effects, but saturated fat and trans unsaturated fatty acids increase risk of coronary heartdisease." 1892 2271 W2151373895.pdf 1 18 separator 0.71847606 ¶ 2271 2273 W2151373895.pdf 1 19 text 0.97058207 "1However, these associations do not seem to apply to stroke. Previous studies have even suggestedan inverse relation between saturated fat or transunsaturated fat intake and risk of stroke, 23but the mechanisms remain unclear. Although epidemiologi-cal studies indicated beneficial effects of some specificfatty acids such as long chain omega 3 polyunsaturatedfatty acid, /afii9825linolenic acid, and linoleic acid on ischaemic stroke, 4–6few studies have directly related intake of dietary fat to risks of subtypes of stroke, andthe results have been inconsistent. We prospectivelyexamined the associations between intakes of total fatand specific types of fat and the risk of subtypes ofstroke in the health professional follow up study." 2273 3025 W2151373895.pdf 1 20 separator 0.99736965 ¶ 3025 3027 W2151373895.pdf 1 21 title 0.9883797 Methods 3027 3035 W2151373895.pdf 1 22 separator 0.9953779 ¶ 3035 3037 W2151373895.pdf 1 23 text 0.53675324 Study 3037 3043 W2151373895.pdf 1 24 title 0.8304205 population 3043 3054 W2151373895.pdf 1 25 text 0.99956083 "The health professional follow up study is a cohort of51 529 male US healthcare professionals, aged 40-75years in 1986, who responded to a mailed questionnaireincluding a comprehensive survey of diet, lifestyle char-acteristics, and medical history. Non-dietary variables areupdated every other year and dietary information everyfour years. For this analysis, we followed participantsfrom 1986 to 2000. We excluded men who at baselinereported a previous diagnosis of cardiovascular diseasesor diabetes mellitus. We also excluded men who hadincomplete information ( ≥70 blanks out of 131 listed food items) or implausible total daily energy intake(≤800 or ≥4200 kcal ( ≤3.34 or ≥17.56 MJ). A total of 43 732 men remained in the analyses. The response tothe questionnaires constituted the participants’informed consent" 3054 3874 W2151373895.pdf 1 26 separator 0.99565995 ¶ 3874 3876 W2151373895.pdf 1 27 title 0.9901189 Dietary assessment 3876 3895 W2151373895.pdf 1 28 separator 0.9937887 ¶ 3895 3897 W2151373895.pdf 1 29 text 0.9695386 "We assessed dietary intake by using semiquantitativefood frequency questionnaires in 1986, 1990, and1994. 7We asked participants to record the frequency of consumption of specified portions of each selectedfood during the previous year by using one of nineoptions ranging from “never or < 1/month” to“≥6/day.” We also inquired about types of fat, oil, or margarine used in food preparation and at the table.We obtained values for the amounts of nutrients,including specific types of fat, in foods from theHarvard University food composition database, whichwas updated over time with data from the US Depart-ment of Agriculture, manufacturers, and publishedreports. We based values for total trans isomer contents in food in part on analyses by Enig et al and SloverDepartment of Nutrition, Harvard" 3897 4705 W2151373895.pdf 1 30 contact 0.5136169 School 4705 4711 W2151373895.pdf 1 31 text 0.5151111 of PublicHealth 4711 4727 W2151373895.pdf 1 32 contact 0.54510117 , 665HuntingtonAvenue, Boston,MA 02115, USA 4727 4770 W2151373895.pdf 1 33 separator 0.9759057 ¶ 4770 4772 W2151373895.pdf 1 34 contact 0.99209905 "Ka He research associate Anwar Merchant research associate Eric B Rimm associate professor Meir J Stampfer professor Walter C Willett professor Alberto Ascherio associate professor Department of Biostatistics,Harvard School ofPublic Health Bernard A Rosner professor Correspondence to: KH ehpkhe@channing.harvard.edu" 4772 5123 W2151373895.pdf 1 35 separator 0.8475649 ¶ 5123 5125 W2151373895.pdf 1 36 paratext 0.9613789 "bmj.com 2003;327:777 page 1 of 6 BMJ VOLUME 327 4 OCTOBER 2003 bmj.com" 5125 5198 W2151373895.pdf 1 0 paratext 0.9895271 Page 3 of 8 0 11 W4378378698.pdf 2 1 separator 0.9801934 ¶ 11 13 W4378378698.pdf 2 2 paratext 0.93533295 Hwang et al. BMC Ophthalmology (2023) 23:236 13 68 W4378378698.pdf 2 3 separator 0.9944879 ¶ 69 71 W4378378698.pdf 2 4 caption 0.9955356 Fig. 1 Illustration of illuminated-chopper . (A) iChopper, Nam illumination probe with a chopper, Korea, and USA Food and Drug Administration 71 214 W4378378698.pdf 2 5 separator 0.5761082 ¶ 215 217 W4378378698.pdf 2 6 caption 0.9957546 cleared (Oculight, South Korea). ( B) Phaco chop using an illuminated chopper. ( C) Still video image of illuminated chopper during phaco chop 217 360 W4378378698.pdf 2 0 title 0.98765457 Секция 6. Иерархически организованные материалы и низкоразмерные структуры 0 75 W4252970627.pdf 2 1 separator 0.85437655 ¶ 77 79 W4252970627.pdf 2 2 title 0.9847167 для биомедицинских приложений 79 109 W4252970627.pdf 2 3 separator 0.9870174 ¶ 111 113 W4252970627.pdf 2 4 text 0.9973181 "405 Срок наблюдения составлял от 15 до 90 суток. После выведения животных из эксперимента по 4 особи из каждой группы на 15, 30, 60 и 90 сутки, исследуемые образцы с окружающими тканями фиксировались в 10% формалине в течение 1 суток. Образцы с костной тканью подвергались декальцинации в растворе смеси муравьиной кислоты и 10% формалина в соотношении 1:4 и подготавливались для микроскопической оценки." 113 531 W4252970627.pdf 2 5 separator 0.9817253 ¶ 533 535 W4252970627.pdf 2 6 text 0.99963635 "Результаты. При макроскопической оценки имплантатов во время забора материала в о всех исследуемых группах имплантаты хорошо фиксировались к окружающим мышечным тканям (в сроки от 15 суток) и к надкостнице (в сроки от 60 суток) за счет прорастания соединительной тканью. В сроки от 60 суток отмечалось постепенное исчезновение имплантата (биодеградация), что выражалось в трудностях интраоперацинной детекции имплантата. Макроскопически ни в одном случае, на всех сроках забора материала, признаков нагноения в области имплантации не выявлено." 535 1099 W4252970627.pdf 2 7 separator 0.97568405 ¶ 1101 1103 W4252970627.pdf 2 8 text 0.9995734 "В ходе проведенного микроскопического исследования установлено, что вокруг всех трех вариантов материала формируется воспалительный гигантоклеточный инфильтрат с наличием гистиоцитов и фибробластов, что не отличается от литературных данных при использовании других, широко используемых в настоящее время в имплантологии материалов [3]. Воспалительный инфильтрат персистирует в течение 60 суток и постепенно замещает резорбируемый материал имплантат, что доказывает биодеградируемость исследуемого материала. К 90 суткам, во всех группах исследуемых образцов, отмечено уменьшение воспалительного инфильтрата (уменьшение количества гигантских клеток)." 1103 1776 W4252970627.pdf 2 9 separator 0.9575747 ¶ 1777 1779 W4252970627.pdf 2 10 text 0.9994894 "Причем отмечено формирование более широкого слоя инфильтрата со стороны мышечной ткани, и меньшей его выраженности со стороны костной ткани. Данное наблюдение свидетельствует о благоприятной тенденции к интеграции исследуемых образцов с костной тканью. Во всех случаях отсутствует замещение воспалительного инфильтрата фиброзной тканью. Остеогенез наблюдался только в случаях повреждения костной ткани как при имплантации к костям черепа, так и к костям таза. Следует отметить, что во всех случаях, чем сильнее была выражена резорбция материала, тем отчетливее определялся остеогенез." 1779 2384 W4252970627.pdf 2 11 separator 0.9643705 ¶ 2385 2387 W4252970627.pdf 2 12 text 0.99749184 "Биодеградируемый имплантат, изготовленный на основе полимера полимолочной кислоты марки PURASORBPL- 38 и органического минерального наполнителя, полученного методом лазерной абляции твердотельной мишени, изготовленной из кальций фосфорнокислого двузамещенного водного индуцирует наиболее выраженный остеогенез." 2387 2707 W4252970627.pdf 2 13 separator 0.9848428 ¶ 2709 2711 W4252970627.pdf 2 14 text 0.9993917 "Выводы. Таким образом, по результатам сравнения трех исследуемых образцов, лучшие интерграционный качества показал биодеградируемый имплантат, изготовленный на основе полимера полимолочной кислоты марки PURASORBPL- 38 и органического минерального наполнителя, полученного методом лазерной абляции твердотельной мишени, изготовленной из кальций фосфорнокислого двузамещенного водного." 2711 3108 W4252970627.pdf 2 15 separator 0.99316144 ¶ ¶ 3110 3116 W4252970627.pdf 2 16 bibliography 0.99819124 "1. F.P.W. Melchels, M.A.N. Domingos, T.J. Klein, J. Malda, P.J. Bartolo, D.W. Hutmacher, Additive manufacturing of tissues and organs, Prog. Polym. Sci. 37 (2012) 1079 –1104. doi:10.1016/j.progpolymsci.2011.11.007." 3116 3334 W4252970627.pdf 2 17 separator 0.90673065 ¶ 3335 3337 W4252970627.pdf 2 18 bibliography 0.9980953 "2. A. Tamayol, M. Akbari, N. Annabi, A. Paul, A. Khademhosseini, D. Juncker, Fiber- based tissue engineering : Progress , challenges , and opportunities, Biotechnol. Adv. 31 (2013) 669 –687. doi:10.1016/j.biotechadv.2012.11.007." 3337 3569 W4252970627.pdf 2 19 separator 0.94829214 ¶ 3570 3572 W4252970627.pdf 2 20 bibliography 0.9980717 "3. Kzhyshkowska J., Gudima A., Riabov V., Dollinger C., Lavalle P., Vrana N.E. Macrophage responses to implants: prospects for personalized medicine // J Leukoc Biol. – 2015. – V. 98. – P. 953- 962." 3572 3774 W4252970627.pdf 2 21 separator 0.99115264 ¶ 3775 3777 W4252970627.pdf 2 0 text 0.99926156 "NF-YC2, improved salinity tolerance in plants. In our previous study, we showed that BnNF-YC2 and BnNF-YC5 grouped with NF-YC2 and NF-YC3 [9] and, like these homologs in Arabidopsis , responded to salinity and drought stress." 0 231 W2068771090.pdf 8 1 separator 0.9613255 ¶ 231 233 W2068771090.pdf 8 2 text 0.99946475 "Since plants have so many NF-Ys, functional redundancy seems inevitable. Arabidopsis NF-YB2 and NF-YB3 function additively in the long-day flowering pathway [34]. LEAFY COTYLEDON 1 (LEC1) and LEAFY COTYLEDON1-LIKE (L1L) were shown to be involved in embryo development [35,36]. Many of the BnNF- Ys characterized in our study were responsive to salinity, drought, or ABA treatment. Some of these members in the same subfamily were clustered in the same phylogenetic clade based on theirpromoter sequences, such as BnNF-YA1 and BnNF-YA2 (Fig. 6)." 233 792 W2068771090.pdf 8 3 separator 0.9777757 ¶ 792 794 W2068771090.pdf 8 4 text 0.9994293 "Further evidence is needed to confirm the roles of these proteins during the abiotic stress response. It would also be interesting to explore whether these proteins from the three subfamilies combine to form trimeric complexes, as reported in yeast and animal systems [37]. It is not known whether the NF-Y complex always has fixed components or whether the components differ under different conditions. Even though extensive correlations in the expression patterns of TaNF-Y subfamily members were identified [18], no three members from the three different BnNF-Y subfamilies exhibited the same expression pattern under all three treatments in our study. This phenomenon implies that the canola BnNF-Y complex does not always consist of the same monomers under different conditions." 794 1602 W2068771090.pdf 8 5 separator 0.9868574 ¶ 1602 1604 W2068771090.pdf 8 6 text 0.9996626 "The plant’s response to abiotic stress involves the transcriptional regulation of genes via their cis-regulatory elements. ABRE, MYB, and MYC elements are known to be involved in the ABA- dependent stress pathway, while the DRE element plays a role in the ABA-independent pathway [38–40]. Two ABRE elements were identified in the promoter region of Arabidopsis drought- responsive NF-YA5, which functioned in an ABA-dependent manner [13]. Interestingly, GmNF-YA3 , a homolog of NF-YA5 , harbored an additional DRE cis-acting element in its promoter, which suggests that soybean NF-YA3 may be involved in both pathways [16]. A previous study of the global expression patterns of rice plants subjected to various abiotic stresses identified more ABRE and DRE elements in the promoter regions of genes responsive to both drought and salinity than in those specifically responsive to drought or salinity stress [41]. In our study, the promoter regions of BnNF-YA11 and BnNF-YA12 , which were strongly induced by salinity and drought stress, each harbored 4 ABRE elements. Canola NF-YB2 andNF-YB3 each possessed at least 5 ABRE elements and were strongly up-regulated by ABA treatments. BnNF-YC2, which contains 2 ABRE elements in its promoter region, was strongly induced by ABA stress. In contrast, the promoter regions of canola NF-YB11 and NF-YB14, which were also strongly induced by ABA or drought treatment, had fewDRE or ABRE elements, but several MYB or MYC elements, suggesting that MYB or MYC play roles in the abiotic stress response." 1604 3194 W2068771090.pdf 8 7 separator 0.98550117 ¶ 3194 3196 W2068771090.pdf 8 8 text 0.9995819 "According to the well-known triangle theory [42,43], canola, an allopolyploid, originated from the hybridization of B. rapa (the A genome) and B. oleaacea (the C genome), while all Brassica species basically arose from common Arabidopsis ancestors. Based on our NF-Y stress-related cis-element analysis and promoter sequence alignments, the upstream regulatory regions of NF-Y sequences of canola were found to be similar to those of Arabidopsis (Fig. 5 and 6). Through extensive comparisons based on nucleotide sequences, homoeologous segments conserved in canola and Arabidopsis were found to exhibit perfect collinearity [44]. Our study revealed that the promoters of canola NF-Ys were more similar to those of B. rapa than to B. oleracea . Canola ( B. napus ) was proposed to havemultiple origins, and natural canola species were found to be more closely related to B. rapa species than to B. oleracea species, according to an Restriction fragment length polymorphisms(RFLP) analysis of nuclear, chloroplastic, and mitochondrial DNA [45]. A recent study found that two canola self-incompat- ibility genes (S-locus glycoproteins, SLGs) and an S-locus receptorkinase (SRK) had higher levels of amino acid sequence identity with their B. rapa homologues than with those from B. oleracea [46], supporting the notion that a subset of canola sequences are more closely related to B. rapa than to B. oleracea ." 3196 4642 W2068771090.pdf 8 9 separator 0.967173 ¶ 4642 4644 W2068771090.pdf 8 10 text 0.99736375 "In conclusion, this study represents an extensive evaluation of BnNF-Y family members under salinity, drought, or ABA stress." 4644 4772 W2068771090.pdf 8 11 separator 0.9780326 ¶ 4772 4774 W2068771090.pdf 8 12 text 0.9994608 "The results presented here offer a useful foundation for further studies of BnNF-Y proteins under abiotic stress conditions. Several BnNF-Y members in each subfamily showed similar expression patterns, indicating that these genes may have redundantfunctions. Members of different families were found to have similar expression patterns, suggesting that BnNF-Ys form a heterocomplex. Our BnNF-Y promoter analysis shows thatmultiple BnNF-Y members contain abiotic stress-responsive elements and provides clues as to the evolution of BnNF-Ys in Brassica species." 4774 5348 W2068771090.pdf 8 13 separator 0.9910735 ¶ 5348 5350 W2068771090.pdf 8 14 title 0.99057585 Supporting Information 5350 5373 W2068771090.pdf 8 15 separator 0.995606 ¶ 5373 5375 W2068771090.pdf 8 16 caption 0.98653084 "Figure S1 Expression pattern of BnNF-Y genes in the leaves and roots of plants subjected to salinity stress for 1o r3h . The expression of BnNF-YA (A),BnNF-YB (B), and BnNF-YC (C) in the leaves and roots of plants exposed to 150 mM NaCl for the indicated periods of time. The transcript levels of each BnNF-Y gene were first normalized to those of the housekeeping gene 18S and then compared to the control (0-hlevel in the leaf). The expression levels of untreated samples (C, 0-h leaf samples) were arbitrarily set to 1.0. L, leaves; R, roots. CK, no treatment; Salt, NaCl treatment. Significant differences between different samples and 0-h samples (same tissue only) are indicated by a single (P ,0.05) or double (P ,0.01) asterisk, according to Dunnett’s method of one-way ANOVA in SPSS. (DOC)" 5375 6198 W2068771090.pdf 8 17 separator 0.992245 ¶ 6198 6200 W2068771090.pdf 8 18 caption 0.9966821 "Figure S2 Expression pattern of BnNF-Y genes exposed to osmotic stress. The expression of BnNF-YA (A),BnNF-YB (B), and BnNF-YC (C) genes in the leaves of plants exposed to treatment with 15% (w/v) PEG-6000 for the indicated periods." 6200 6439 W2068771090.pdf 8 19 separator 0.94533914 ¶ 6439 6441 W2068771090.pdf 8 20 caption 0.6716702 The 6441 6446 W2068771090.pdf 8 21 text 0.52434015 transcript 6446 6456 W2068771090.pdf 8 22 caption 0.5769365 6456 6457 W2068771090.pdf 8 23 text 0.4777369 levels 6457 6463 W2068771090.pdf 8 24 caption 0.5228511 of 6463 6467 W2068771090.pdf 8 25 text 0.8885214 "each BnNF-Y gene were first normalized to those of the housekeeping gene 18S and then compared to the levels in the 0-h leaf control." 6467 6604 W2068771090.pdf 8 26 caption 0.5471973 6604 6605 W2068771090.pdf 8 27 text 0.58161575 Expression 6605 6615 W2068771090.pdf 8 28 caption 0.6263402 6615 6616 W2068771090.pdf 8 29 text 0.535371 levels 6616 6622 W2068771090.pdf 8 30 caption 0.5427022 in 6622 6625 W2068771090.pdf 8 31 text 0.6830948 untreated 6625 6636 W2068771090.pdf 8 32 caption 0.600746 ¶ 6636 6638 W2068771090.pdf 8 33 text 0.62275165 samples (C, 0-h leaf 6638 6658 W2068771090.pdf 8 34 caption 0.7288245 6658 6659 W2068771090.pdf 8 35 text 0.4896465 samples 6659 6666 W2068771090.pdf 8 36 caption 0.9066254 ") were arbitrarily set to 1.0. L, leaves; R, roots. CK, no treatment; Drought, PEG6000 treatment." 6666 6765 W2068771090.pdf 8 37 separator 0.87629175 ¶ 6765 6767 W2068771090.pdf 8 38 caption 0.90689623 "Significant differences between different samples and 0-h samples(same tissue only) are indicated by a single (P ,0.05) or double (P , 0.01) asterisk, according to Dunnett’s method of one-way ANOVA in SPSS." 6767 6978 W2068771090.pdf 8 39 separator 0.5126937 ¶ 6978 6980 W2068771090.pdf 8 40 caption 0.96277 (DOC) 6980 6986 W2068771090.pdf 8 41 separator 0.99206954 ¶ 6986 6988 W2068771090.pdf 8 42 caption 0.9967697 "Figure S3 Expression pattern of the BnNF-Y genes after exposure to 100 mM ABA. The expression of BnNF-YA (A), BnNF-YB (B), and BnNF-YC (C) genes in the leaves and roots of plants exposed to 100 mM ABA. Transcript levels of each BnNF-Y were first normalized to those of the housekeeping gene 18S and then compared to levels at 0 h in the control (untreated) leaves." 6988 7363 W2068771090.pdf 8 43 separator 0.58830863 ¶ 7363 7365 W2068771090.pdf 8 44 caption 0.98352575 "Expression levels in untreated samples (CK, 0-h leave samples) were arbitrarily set to 1.0. L, leaves; R, roots. CK, no treatment;ABA, ABA treatment. Significant differences between different samples and 0-h samples (same tissue only) are indicated by aCanola NF-Y Response to Abiotic Stress" 7365 7661 W2068771090.pdf 8 45 separator 0.96779126 ¶ 7661 7663 W2068771090.pdf 8 46 paratext 0.98415464 PLOS ONE | www.plosone.org 9 October 2014 | Volume 9 | Issue 10 | e111354 7663 7737 W2068771090.pdf 8 0 paratext 0.9882665 Energies 2022 ,15, 7166 15 of 16 0 32 W4297973295.pdf 14 1 separator 0.9936287 ¶ 32 34 W4297973295.pdf 14 2 text 0.99678653 "of renewables are worth being introduced into the proposed models as boundary conditions for optimization as well. Therefore, research with the objective function of minimizing the power imbalance between supply and demand will be carried out in the future. The integrated energy systems will replace the current CHP system as new research objects, while real-time data of renewables will be introduced." 34 446 W4297973295.pdf 14 3 separator 0.99524987 ¶ 446 448 W4297973295.pdf 14 4 bibliography 0.87872845 "Author Contributions: Writing—original draft, L.Z.; methodology, writing—review and editing, C.L.; writing—review and editing, C.W.; conceptualization, writing—review, editing and investigation, J.S." 448 650 W4297973295.pdf 14 5 separator 0.7994733 ¶ 650 652 W4297973295.pdf 14 6 paratext 0.8853932 All authors have read and agreed to the published version of the manuscript. 652 729 W4297973295.pdf 14 7 separator 0.9212048 ¶ 729 731 W4297973295.pdf 14 8 paratext 0.7873282 "Funding: This research is financially supported by Project of State Grid Shandong Electric Power Research Institute (zy-2022-10)." 731 862 W4297973295.pdf 14 9 separator 0.98275816 ¶ 862 864 W4297973295.pdf 14 10 paratext 0.63869405 Data Availability Statement: Data sharing not applicable. 864 922 W4297973295.pdf 14 11 separator 0.79414916 ¶ 922 924 W4297973295.pdf 14 12 paratext 0.63529634 Conflicts of Interest: The authors declare no conflict of interest. 924 990 W4297973295.pdf 14 13 separator 0.9929165 ¶ 990 992 W4297973295.pdf 14 14 title 0.6994482 References 992 1003 W4297973295.pdf 14 15 separator 0.97766304 ¶ 1003 1005 W4297973295.pdf 14 16 bibliography 0.9979029 "1. 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Affinity of anti-L YVE-1 antibody is maintained after radiolabeling with 125I." 160 269 W4361969411.pdf 2 8 separator 0.9458427 ¶ 270 272 W4361969411.pdf 2 9 caption 0.77920485 Competitive radioimmunoassay: Increasing amo 272 317 W4361969411.pdf 2 10 text 0.39801228 un 317 320 W4361969411.pdf 2 11 caption 0.7253323 ts of unlabeled anti-LYVE-1 antibody dose- 320 362 W4361969411.pdf 2 12 text 0.70485705 ¶ 362 364 W4361969411.pdf 2 13 caption 0.5243431 364 365 W4361969411.pdf 2 14 text 0.8536483 "dependently inhibited binding of 26 nM 125I-anti-LYVE-1 to immobilized LYVE-1. Half maximal binding of 125I-anti-LYVE-1 was reached at equal concentrations of both antibodies." 365 543 W4361969411.pdf 2 15 separator 0.97680473 ¶ ¶ 544 550 W4361969411.pdf 2 16 caption 0.9880949 "Supplementary Figure 2. A systemically admini stered antibody to VEGFR-3 accumulates in the lymphatic vasculature." 550 668 W4361969411.pdf 2 17 separator 0.9880196 ¶ 670 672 W4361969411.pdf 2 18 text 0.47757652 Differential immuno 672 692 W4361969411.pdf 2 19 title 0.44102857 fluorescence 692 704 W4361969411.pdf 2 20 text 0.47270325 an 704 708 W4361969411.pdf 2 21 title 0.49256694 alysis 708 714 W4361969411.pdf 2 22 text 0.5076644 of systemically 714 730 W4361969411.pdf 2 23 title 0.50811046 inj ected 730 740 W4361969411.pdf 2 24 text 0.91079307 "anti-VEGFR -3 antibody in sections of control (A – D) and inflamed auricular LNs (E – H). The injected antibody to VEGFR-3 (B and F, red) co-localized with LYVE -1 stained lymphatic vessels (C and G; green) in control and inflamed auricular LNs. (D) Merged panels B and C. (H) Merged panels F and G." 740 1050 W4361969411.pdf 2 25 separator 0.72521555 ¶ 1051 1053 W4361969411.pdf 2 26 text 0.99626976 "In contrast, the injected control IgG (J; red) di d not co-localize with LYVE-1-positive lymphatic vessels (K, green). (A, E, I) Nucl ei were stained with Hoechst dye (blue). Scale bars = 100 μm." 1053 1252 W4361969411.pdf 2 27 separator 0.97164994 ¶ ¶ 1253 1259 W4361969411.pdf 2 28 caption 0.98488116 "Supplementary Figure 3. A systemically inj ected radiolabeled antibody to VEGFR-3 accumulates in the lymphatic vasculature." 1259 1386 W4361969411.pdf 2 0 paratext 0.9899507 Electronics 2022 ,11, 2983 22 of 26 0 35 W4296466709.pdf 21 1 separator 0.99212945 ¶ 35 37 W4296466709.pdf 21 2 text 0.9893158 "set of common quantum task types comprising typical configuration options. Rather, users have to start building their workflow from scratch by means of writing a YAML file. " 37 210 W4296466709.pdf 21 3 separator 0.5096048 ¶ 210 211 W4296466709.pdf 21 4 text 0.99878097 "In contrast, our approach uses standardized workflow models that can be executed on full-fledged workflow engines, providing advantages, such as robustness and scalability." 211 383 W4296466709.pdf 21 5 separator 0.91028136 ¶ 383 385 W4296466709.pdf 21 6 text 0.9994262 "Another framework for executing quantum workflows is Covalent [108]. It is a Pythonic workflow tool specialized for executing tasks on HPC and quantum hardware. The work- flow is generated by annotating the code with Covalent-specific decorators. In contrast to our approach, it is not based on a standardized workflow language and does not provide workflow-typical features such as transactions, error-compensation, and user tasks." 385 820 W4296466709.pdf 21 7 separator 0.9967121 ¶ 820 822 W4296466709.pdf 21 8 title 0.99153197 8. Conclusions and Future Work 822 853 W4296466709.pdf 21 9 separator 0.9966551 ¶ 853 855 W4296466709.pdf 21 10 text 0.99954534 "A variety of error mitigation methods have been developed to improve the perfor- mance of today’s noisy quantum devices. To facilitate the integration of REM in quantum applications, we first analyzed the literature for existing methods. We categorized the found methods and summarized their basic functionality to ease their understanding. Further, we evaluated the methods’ configuration options to identify common and method-specific options that need to be considered when integrating REM into a quantum application. As quantum applications typically contain many quantum and classical software components, implementing, configuring, deploying, and orchestrating all components manually is error- prone and time-consuming. Thus, workflow technologies have been proposed as a means for orchestrating quantum applications. To automate the REM process in a configurable manner, we introduced an approach integrating service-based, configurable, and extensi- ble REM into quantum workflows. To validate our approach, we provide a prototypical implementation and employ it in a case study from the quantum humanities domain." 855 1995 W4296466709.pdf 21 11 separator 0.959941 ¶ 1995 1997 W4296466709.pdf 21 12 text 0.999431 "In future work, we plan to further extend our prototype by providing accurate cost estimations for performing REM for different quantum providers. Furthermore, we will integrate REM in the NISQ Analyzer [ 83] to facilitate the hardware selection process. More- over, we plan to compare the presented REM methods using a model-driven benchmarking approach. As hybrid runtimes, such as Qiskit Runtime [ 96] or Amazon Braket Hybrid Jobs [ 97], are becoming more popular, we plan to investigate how our workflow-based REM approach can be combined with current hybrid runtime environments. Finally, we plan to investigate whether our approach is also applicable to other types of error mitigation, such as gate error mitigation, and we extend our prototype to support these methods too." 1997 2794 W4296466709.pdf 21 13 separator 0.99695915 ¶ 2794 2796 W4296466709.pdf 21 14 bibliography 0.9222028 "Author Contributions: Conceptualization, M.B., J.B., F.L., F.T., B.W., and V .Y.; methodology, M.B., J.B., F.L., F.T., B.W., and V .Y.; software, M.B., F.T., and B.W.; validation, M.B., F.T., B.W., and V .Y.; investigation, M.B., F.T., B.W., and V .Y.; resources, M.B.; data curation, M.B.; writing—original draft preparation, M.B., F.T., B.W., and V .Y.; writing—review and editing, J.B. and F.L.; visualization, M.B., F.T., B.W., and V .Y.; supervision, J.B. and F.L.; project administration, J.B. and F.L.; funding acquisition, J.B. and F.L. All authors have read and agreed to the published version of the manuscript." 2796 3428 W4296466709.pdf 21 15 separator 0.98801243 ¶ 3428 3430 W4296466709.pdf 21 16 text 0.9796237 "Funding: This work was partially funded by the BMWK projects PlanQK (01MK20005N), EniQmA (01MQ22007B), and SeQuenC (01MQ22009B), and by the project SEQUOIA funded by the Baden- Wuerttemberg Ministry of Economic Affairs, Labour and Tourism." 3430 3674 W4296466709.pdf 21 17 separator 0.9609413 ¶ 3674 3676 W4296466709.pdf 21 18 text 0.7283634 "Data Availability Statement: The prototypical implementations and case study presented in this work are available on GitHub [82,86,90]." 3676 3814 W4296466709.pdf 21 19 separator 0.9135345 ¶ 3814 3816 W4296466709.pdf 21 20 text 0.65293103 Conflicts of Interest: The authors declare no conflicts of interest. 3816 3883 W4296466709.pdf 21 21 separator 0.994805 ¶ 3883 3885 W4296466709.pdf 21 22 title 0.8687542 References 3885 3896 W4296466709.pdf 21 23 separator 0.98730767 ¶ 3896 3898 W4296466709.pdf 21 24 bibliography 0.99784046 "1. Cao, Y.; Romero, J.; Olson, J.P .; Degroote, M.; Johnson, P .D.; Kieferová, M.; Kivlichan, I.D.; Menke, T.; Peropadre, B.; Sawaya, N.P .; et al. Quantum chemistry in the age of quantum computing. Chem. Rev. 2019 ,119, 10856–10915. [CrossRef] [PubMed]" 3898 4154 W4296466709.pdf 21 25 separator 0.85153353 ¶ 4154 4156 W4296466709.pdf 21 26 bibliography 0.997824 "2. Cao, Y.; Romero, J.; Aspuru-Guzik, A. Potential of quantum computing for drug discovery. IBM J. Res. Dev. 2018 ,62, 6:1–6:20. [CrossRef]" 4156 4298 W4296466709.pdf 21 27 separator 0.7140401 ¶ 4298 4300 W4296466709.pdf 21 28 bibliography 0.9977985 3. Preskill, J. Quantum computing in the NISQ era and beyond. Quantum 2018 ,2, 79. [CrossRef] 4300 4394 W4296466709.pdf 21 29 separator 0.8785066 ¶ 4394 4396 W4296466709.pdf 21 30 bibliography 0.9978531 4. Jozsa, R. Entanglement and quantum computation. arXiv 1997 , arXiv:quant-ph/9707034. 4396 4484 W4296466709.pdf 21 0 paratext 0.98961896 Pharmaceutics 2023 ,15, 1281 2 of 14 0 36 W4366417201.pdf 1 1 separator 0.9948636 ¶ 36 38 W4366417201.pdf 1 2 text 0.9997389 "Therefore, the polymer-modified PDA nanoparticles improve drugs’ retention ability and the prolonged release of drugs [ 7,8]. These PDA NPs, however, displayed considerable toxicity to healthy cells and tissues due to their non-specificity. Two efficient methods for resolving the aforementioned issue include creating responsive PDA-based nanoformu- lations and grafting some targeting units on the PDA-based nanoformulations [ 8]. With regard to PTT with PDA, the recent literature has focused on functionalizing PDA-based nanoparticles to enhance their drug delivery efficiency, targeting ability, and therapeutic efficacy. One approach involves using ligands or antibodies to functionalize the surface of polydopamine-based nanoparticles to improve their targeting ability. For example, targeting ligands such as folic acid and aptamers have been conjugated to the surface of PDA-based nanoparticles to selectively target cancer cells that overexpress specific re- ceptors [ 9–12]. Another approach involves incorporating additional functional groups or moieties onto the surface of PDA-based nanoparticles to enhance their drug loading capacity or promote controlled drug release [ 13–15]. For example, thiol or amine groups can be incorporated onto the surface of PDA-based nanoparticles to enhance their drug loading capacity or enable conjugation of other therapeutic agents or targeting moieties [ 16–18]. In addition to surface functionalization, recent studies have explored the use of PDA-based nanoparticles in combination with other therapeutic modalities such as photothermal ther- apy and gene therapy [ 13–15]. For example, PDA-based nanoparticles have been used as carriers for both chemotherapy drugs and photothermal agents to enable synergistic chemo-photothermal therapy. Overall, functionalized PDA-based nanoparticles show great promise for improving cancer drug delivery and overcoming some of the limitations asso- ciated with conventional drug delivery approaches. However, further research is needed to optimize their design and evaluate their long-term safety and efficacy in clinical settings." 38 2201 W4366417201.pdf 1 3 separator 0.9856261 ¶ 2201 2203 W4366417201.pdf 1 4 text 0.9997314 "Natural polymers such as chitosan, sodium alginate, starch, and pectin have been utilized for DDSs to improve the bioavailability of many potential drugs [ 19]. Among these, chitosan (CS) is one of the most promising for DDSs [ 20]. It has mucoadhesive, permeation- enhancing, in situ gelling, and efflux pump inhibitory effects because of its cationic nature." 2203 2569 W4366417201.pdf 1 5 separator 0.86806893 ¶ 2569 2571 W4366417201.pdf 1 6 text 0.9973522 "Additionally, a controlled medication release can be accomplished via ionic interactions, and nanoparticulate delivery systems for siRNA and pharmaceuticals based on DNA can be created [ 21]. Carboxymethyl chitosan (CMCS) is a modified CS that also attracted drug delivery in cancer therapy. It has carboxylic and cationic amino groups, which are responsible for the loading of drugs via the formation of H-bonding and complexation and which can deliver the drug molecules easily in the tumor microenvironment [ 22]. As of late, it has been shown that CMCS derived from non-animal sources of fungal mushrooms (FC) has outstanding physiological and biological characteristics, including increased water solubility in a wide range of pH solutions, biodegradability, and excellent biocompatibility. " 2571 3383 W4366417201.pdf 1 7 separator 0.6447751 ¶ 3383 3384 W4366417201.pdf 1 8 text 0.9994962 "Therefore, FC has been utilized for the preparation of nanocomposites, films, and hydrogels for biomedical applications [23–25]." 3384 3514 W4366417201.pdf 1 9 separator 0.9806186 ¶ 3514 3516 W4366417201.pdf 1 10 text 0.999723 "By considering the excellent properties of FC and the PTT ability of PDA, herein we developed FCPDA nanoparticles for loading Dox as a chemotherapeutic agent. The presence of amino functional groups on FC biopolymer can easily be covalently bonded to the DOPA structure during the formation of PDA, thereby stabilizing the FCPDA nanopar- ticles. By considering the excellent properties of FC, the FCPDA nanoparticles are easily allowed to encapsulate with Dox drug via the formation of multiple bonds such as H-bond, complexation, and pi-pi stacking. The resulting Dox@FCPDA nanoparticle was studied for its combined chemo and photothermal properties for cancer therapy." 3516 4201 W4366417201.pdf 1 11 separator 0.99706584 ¶ 4201 4203 W4366417201.pdf 1 12 title 0.9927446 2. Materials and Methods 4203 4228 W4366417201.pdf 1 13 separator 0.9950466 ¶ 4228 4230 W4366417201.pdf 1 14 title 0.88877356 2.1. Materials 4230 4245 W4366417201.pdf 1 15 separator 0.9940951 ¶ 4245 4247 W4366417201.pdf 1 16 text 0.99926543 "The Endovision Company (Daegu, Republic of Korea) kindly provided FC (originated from Agaricus Bisporous Mushroom) with MW = 200–2000 KDa (viscosity 20–1000 cps with deacetylation 80–98%). DA was purchased from Sigma Aldrich Company, Seoul, Republic" 4247 4501 W4366417201.pdf 1 0 paratext 0.974326 "Oncotarget34233 www.impactjournals.com/oncotarget" 0 51 W2517093136.pdf 10 1 separator 0.8673408 ¶ 51 53 W2517093136.pdf 10 2 text 0.9974238 "kit. The resin was collected by centrifuging for 30 s at 8200 × g after agitated for overnight at 4°C. The Flag- IKKβ was eluted by competition with 3 × Flag peptide, and stored at −80°C or further conduct IKKβ kinase assay and competition assay." 53 311 W2517093136.pdf 10 3 separator 0.996696 ¶ 311 313 W2517093136.pdf 10 4 title 0.9927343 IKKβ kinase assay 313 331 W2517093136.pdf 10 5 separator 0.99086803 ¶ 332 334 W2517093136.pdf 10 6 text 0.99950325 "To determine the effect of ILG on IKKβ activity, the IKKβ kinase assay was performed. Briefly, IκBα substrate supplied by Enzo Life Science (Farmingdale, NY , USA), Flag-IKKβ recombinant protein, and ATP were incubated with or without ILG at 30°C for 30 min. The mixture was analyzed by 10% SDS-polyacrylamide gel electrophoresis (SDS-PAGE), and then electro-transferred onto nitrocellulose membranes. The nitrocellulose membranes were incubated with P-IκBα (Ser32/36) for overnight at 4°C after blocked by 5% dried milk for 60 min. Next day, the membranes were further incubated with HRP-conjugated secondary antibodies for 60 min, and developed using ECL Western Blotting Detection Reagents (Life Technologies)." 334 1087 W2517093136.pdf 10 7 separator 0.9968909 ¶ 1087 1089 W2517093136.pdf 10 8 title 0.99224883 Competition assay 1089 1107 W2517093136.pdf 10 9 separator 0.9919794 ¶ 1107 1109 W2517093136.pdf 10 10 text 0.9996679 "Flag-IKKβ wild type (wt) was precipitated from HEK 293 overexpressing Flag-IKKβ, and incubated with ILG or DMY for 1h and then 100 μM DMY-biotin was added to the mixture. Subsequently, the proteins were separated by SDS-PAGE and transferred to nitro-cellulose membranes. After blocking with BSA and washing with PBST, the membranes were incubated with streptavidin horseradish peroxidase for 1 h and developed with enhanced chemiluminescence. Finally, the membranes were incubated with anti-Flag antibody to evaluate the expression of Flag-IKKβ." 1109 1685 W2517093136.pdf 10 11 separator 0.99676406 ¶ 1685 1687 W2517093136.pdf 10 12 title 0.9913833 Computational methods 1687 1709 W2517093136.pdf 10 13 separator 0.9942679 ¶ 1710 1712 W2517093136.pdf 10 14 text 0.99396163 "The initial 3D structure of ILG was built using the Molecule Builder module incorporated in MOE software. The structure was then subjected to energy minimization and partial charges calculation with Amber99 force field. The crystal structure of wild-type inhibitor of κB kinase β (IKKβ) was retrieved from Protein Data Bank (PDB ID code 3RZF [38]). On the basis of the wild type protein structure, the structure of IKKβ with C46A mutant was obtained by performing single point mutation with Rotamer Explorer in MOE software. To prepare the protein for molecular docking, the protein structure was subjected to partial charges calculation and energy minimization with Amber99 force field. Energy minimization was terminated when the root mean square gradient falls below 0.05 kcal/(mol·Å)." 1712 2540 W2517093136.pdf 10 15 separator 0.98713493 ¶ 2540 2542 W2517093136.pdf 10 16 text 0.99964595 "The prepared proteins and ligand were introduced for molecular docking. The docking site was identified by using Site Finder in MOE software. The identified binding site including residue Cys46 was chosen as the binding site for molecular docking according to our experiment. In molecular docking, the Triangle Matcher placement method and London dG scoring function were used. A total of 30 docking poses were generated for the ligand and the pose with the best binding mode was selected for further analysis." 2542 3074 W2517093136.pdf 10 17 separator 0.9971683 ¶ 3074 3076 W2517093136.pdf 10 18 title 0.99384904 IKK-βC46A transgenic mice 3076 3102 W2517093136.pdf 10 19 separator 0.9937118 ¶ 3102 3104 W2517093136.pdf 10 20 text 0.9993495 "The IKK-βC46A transgenic mice were generated by Shanghai Biomodel Organism Science & Technology Development Co., Ltd. (Shanghai, China). The transgenic mice were validated by PCR and gene sequencing. The IKK-βC46A mice have been backcrossed to C57BL/6 for 6 generations in our experiments, and the wild-type littermates were served as control. They were kept under 12:12 h cycle of light with ad libitum access to food and drink. All mice were kept under specific pathogen-free conditions in the animal care facility at Guangdong Provincial Hospital of Traditional Chinese Medicine. Animal care and experiments were conducted in accordance with the Laboratory Animal Research Committee Guidelines of Guangdong Provincial Hospital of Traditional Chinese medicine." 3104 3911 W2517093136.pdf 10 21 separator 0.99621683 ¶ 3911 3913 W2517093136.pdf 10 22 title 0.9911214 DTH animal model 3913 3930 W2517093136.pdf 10 23 separator 0.9930211 ¶ 3930 3932 W2517093136.pdf 10 24 text 0.99938947 "Mice were sensitized through topical application onto their shaved abdomens of 20 μl of a 0.5% DNFB in 4:1 acetone/olive oil mixture on days 0 and 1(sensitization phase). Five days after sensitization, the mice were challenged on day 6 with application of 20 μl of a 0.5% DNFB in 4 : 1 acetone/olive oil mixture to the left inner and outer surfaces of the mice (elicitation phase). Ear thickness measurements of both the treatment and control/blank groups were taken with an electronic digital caliper at 24, 48 and 72 h after challenge and the response quantitated as the difference in the thickness of the challenged ear." 3932 4589 W2517093136.pdf 10 25 separator 0.9969402 ¶ 4589 4591 W2517093136.pdf 10 26 title 0.9905329 Statistical analysis 4591 4612 W2517093136.pdf 10 27 separator 0.98514175 ¶ 4612 4614 W2517093136.pdf 10 28 text 0.9988712 "Data are expressed as means ± S.E.M. One-way ANOV A or Student’s t-test was used to determine the significance of difference; a value of p < 0.05 was considered statistically significant." 4614 4811 W2517093136.pdf 10 29 separator 0.9968657 ¶ 4811 4813 W2517093136.pdf 10 30 title 0.989196 ACKNOWLEDGMENTS 4813 4829 W2517093136.pdf 10 31 separator 0.9920474 ¶ 4829 4831 W2517093136.pdf 10 32 text 0.96466804 "We thank Prof Tom Gilmore (Boston University) for the gift of IKKβ wild type plasmids. Australia" 4831 4931 W2517093136.pdf 10 33 separator 0.55347 ¶ 4932 4934 W2517093136.pdf 10 34 paratext 0.51411873 Innovation Patent No.: 2015100662; 4934 4969 W2517093136.pdf 10 35 text 0.43292153 grant 4969 4975 W2517093136.pdf 10 36 paratext 0.5468791 "ed on 28, May 2015." 4975 4997 W2517093136.pdf 10 0 paratext 0.9830408 284 Vol. 16, No. 3 , 2020 Mìžnarodnij endokrinologìčnij žurnal ,ISSN 2224-0721 (print), ISSN 2307-1427 (online) 0 111 W3081972210.pdf 6 1 separator 0.99411976 ¶ 111 113 W3081972210.pdf 6 2 text 0.9393231 "Огляд літератури /Literature Review/спровокувати ТК. Причому активну антибактеріальну терапію рекомендують навіть при найменшій підозрі на інфекційно-запальний процес." 113 288 W3081972210.pdf 6 3 separator 0.97263384 ¶ 288 290 W3081972210.pdf 6 4 text 0.9923093 "Лікування у рефрактерних випадках. У разі не- ефективності стандартної схеми лікування впродовж 24–48 годин доцільно розглянути такі додаткові можливості." 290 453 W3081972210.pdf 6 5 separator 0.9555939 ¶ 453 455 W3081972210.pdf 6 6 text 0.99954635 "Еферентна терапія (зазвичай плазмаферез, рідше — гемосорбція чи діаліз) дає хворому реальний шанс за- вдяки швидкій елімінації з кров’яного русла надлишку ТГ та інших токсичних метаболітів; через це рекомен- дується багатьма фахівцями та експертами за умови прогресування поліорганної (особливо печінкової) недостатності [4, 5, 13]. Щоправда, існують застере- ження, які стосуються ефекту «рикошету» з повторним підйомом концентрацій ТГ , додаткового навантаження на систему кровообігу , впливу високих доз гепарину на зв’язування ТГ з транспортними протеїнами та ризику тромбоцитопенії [3]. У даний час відсутні проспектив- ні дослідження, що б переконливо доводили ефектив- ність такої тактики [4]." 455 1190 W3081972210.pdf 6 7 separator 0.97427225 ¶ 1190 1192 W3081972210.pdf 6 8 text 0.9970422 "Тиреоїдектомія в ургентному порядку , попри підви- щений операційний ризик, здатна суттєво поліпшити результати лікування пацієнтів із ТК за умови неефек- тивності стандартної фармакотерапії при збереженій ЩЗ. Доволі революційна ідея ранньої операції при йод-індукованому ТК зародилася у провідних клініках Німеччини у 80-х роках ХХ сторіччя (Dralle H., Herr- mann J., R öher H. та інші відомі хірурги), згодом поши- рилась як усередині країни, так і на інші європейські центри. У США тривалий час стримано сприймали та- кий підхід, однак сьогодні від нього не відмовляються й тамтешні фахівці [1, 5, 11]." 1192 1826 W3081972210.pdf 6 9 separator 0.9894141 ¶ 1827 1829 W3081972210.pdf 6 10 text 0.9969182 "Відомі приклади вдалого поєднання в одного паці- єнта різних методів. На сайті клініки Мейо описаний унікальний клінічний випадок ТК, що розвинувся в 33-річної жінки через півроку після пологів на ґрунті недіагностованої хвороби Г рейвса [14]. Незважаючи на інтенсивну терапію, стан пацієнтки залишався тяж- ким через прогресування гемодинамічних розладів аж до кардіогенного шоку; з метою тимчасової підтримки серцевої діяльності додатково застосовано метод екс- тракорпоральної мембранної оксигенації. Оскільки через п’ять днів пацієнтка все ще перебувала в критич- ному стані, спричиненому тиреотоксикозом, вирішено розпочати плазмаферез з метою швидкої підготовки до здійснення тиреоїдектомії. У післяопераційному періо- ді стан пацієнтки суттєво поліпшився, однак скоротли- ва функція серця залишалась вкрай низькою (фракція викиду 15 %), тому було застосовано кардіостимуляцію та рекомендовано трансплантацію серця." 1829 2796 W3081972210.pdf 6 11 separator 0.9942318 ¶ 2796 2798 W3081972210.pdf 6 12 text 0.75852734 Особливості лікар 2798 2816 W3081972210.pdf 6 13 title 0.5150023 ської 2816 2821 W3081972210.pdf 6 14 text 0.9921098 "тактики в нестандартних ситуаціях. Ідеться про ті нечасті випадки ТК, в осно- ві яких лежать інші причини, аніж хвороба Г рейвса — Базедова; вони потребують суттєвої корекції наведеної вище стандартної схеми. Скажімо, при тиреопатіях, що супроводжуються деструктивним тиреотоксикозом (підгострий тиреоїдит де Кервена, аміодарон-інду- кований тиреотоксикоз 2-го типу), використання ти- реостатиків і препаратів йоду абсолютно не доцільне; акцент зміщується на активну протизапальну терапію глюкокортикоїдами або нестероїдними протизапаль- ними засобами та симптоматичне лікування. При ТК, спричиненому значним передозуванням екзогенних ТГ , необхідна передусім їх негайна відміна, а також комплекс підтримуючих заходів." 2821 3575 W3081972210.pdf 6 15 separator 0.97399664 ¶ 3575 3577 W3081972210.pdf 6 16 text 0.99970204 "Найбільш проблематичним вважається лікування йод-індукованого ТК у пацієнтів із функціональною автономією ЩЗ (включаючи аміодарон-індукований тиреотоксикоз 1-го типу), що, як відомо, відзначаєть- ся рефрактерністю навіть до максимальних доз тирео- статиків. У таких випадках інтенсифікують антитире- оїдну та системну підтримуючу терапію, категорично уникаючи препаратів йоду . При цьому дози тіамазолу інколи сягають 80–160 мг/добу , карбімазолу — 120– 180 мг/добу (!), через це оптимальним виходом у такій ситуації вважають невідкладну тиреоїдектомію, краще після підготовки за допомогою плазмаферезу [2, 6, 15]." 3577 4221 W3081972210.pdf 6 17 separator 0.9684811 ¶ 4222 4224 W3081972210.pdf 6 18 text 0.99965763 "Більше того, деякі автори наполягають на її проведен- ні впродовж 12–24 годин, адже летальність після опе- рації, здійсненої в І–ІІ стадіях ТК, перебуває в межах 10 %, а в ІІІ стадії — 28,6 % [6]." 4224 4428 W3081972210.pdf 6 19 separator 0.995561 ¶ 4429 4431 W3081972210.pdf 6 20 title 0.9876615 Прогноз 4431 4439 W3081972210.pdf 6 21 separator 0.9965054 ¶ 4439 4441 W3081972210.pdf 6 22 text 0.99969375 "Завдяки створенню і впровадженню у широку клінічну практику антитиреоїдних лікарських засо- бів, β-адреноблокаторів, нейролептиків та інших лі- кувальних заходів летальність при ТК кардинально знизилась і вже у 1990-х становила 20–50 % залежно від стадії [2]. Сьогодні, за даними ЕТА, летальність становить близько 10 % [10], інші автори озвучують 10–20 % [1, 3–5]. Вірогідними предикторами песи- містичного прогнозу служать прогресуючі гіпертер- мія, тахіаритмія та порушення діяльності ЦНС, а також приєднання жовтяниці. Смерть може настати внаслідок серцевої та/або дихальної недостатності, шоку , поліорганної недостатності, гіпертермії, дисе- мінованої внутрішньосудинної коагуляції, сепсису або інших ускладнень. Зрештою, якщо пацієнти ви- живають, у частини з них спостерігаються необоротні розлади, як-от: постгіпоксична енцефалопатія, цере- броваскулярна патологія, атрофія м’язів, психози або ниркова недостатність [4, 5]." 4441 5421 W3081972210.pdf 6 23 separator 0.9964905 ¶ 5421 5423 W3081972210.pdf 6 24 title 0.98594034 Перспективи в лікуванні ТК 5423 5450 W3081972210.pdf 6 25 separator 0.99574506 ¶ 5450 5452 W3081972210.pdf 6 26 text 0.98993796 "Японські фахівці у своїх настановах [4] сформулю- вали низку проблемних питань, розробка яких, на їх думку , може позитивно вплинути на результати ліку- вання ТК. Серед них: — Який тиреостатик краще підходить для терапії — тіамазол чи пропілтіоурацил? — Чи впливає терапія глюкокортикоїдами на кін- цевий прогноз? — Наскільки необхідна терапія психотропними за- собами при легких розладах свідомості? — Чи можуть ранні заходи з реабілітації запобігти неврологічним ускладненням ТК?" 5452 5959 W3081972210.pdf 6 27 separator 0.93949 ¶ 5959 5961 W3081972210.pdf 6 28 text 0.9996028 "Окрім цього, японські експерти наголошують на двох аспектах, які доцільно зробити предметом май- бутніх клінічних досліджень: лікування порушень ко-" 5961 6115 W3081972210.pdf 6 0 text 0.9994386 "clinical isolates and triazole resistance, as well characterize genetic variation in known virulence factors. We believe that the two works used the orthologs ’intraspecies analysis to deeply investigate different aspects of A. fumigatus genome variation. Thus, the distribution of orthol- ogous genes provided here contains information important to the Aspergillus research com- munity (see supplemental file 2 at the URL above), as well the possibility of identifying Af293 ortholog genes on the PanOrtho genome (see supplemental file 4 at the URL above)." 0 565 W4283728280.pdf 10 1 separator 0.98563075 ¶ 565 567 W4283728280.pdf 10 2 text 0.965779 "Across all isolates, we found that A. fumigatus harbors variation in terms of the number of total predicted protein coding genes ranging between 8,857 and 9,638 (for the clinical isolate IFM59779 and environmental isolate SRR10714233/B-1-26-5, respectively) (see sup-plemental Table 1 at https:// figshare.com/articles/dataset/Examination_of_genome-wide _ortholog_variation_in_clinical_and_environmental_isolates_of_the_fungal_pathogen _Aspergillus_fumigatus/19873927" 567 1042 W4283728280.pdf 10 3 separator 0.94454837 ¶ 1042 1044 W4283728280.pdf 10 4 text 0.99768424 "). The isolates with the largest number of genes clas- sified exclusively as core genome were the clinical isolate MO78722EXP and the environmen- tal isolate ISSFT-021, which was obtained from the International Space Station, with 7,877 and7,867 genes classi fied, respectively. In the AC set, the clinical isolates IFM59361 and 12- 7504462 had the highest number of AC classi fied genes, 1,570 and 1,521, respectively (see supplemental file 7 at the URL above), revealing variation in gene copy numbers (no, single, or multiple gene copies) across isolates (Fig. 3A ). Other studies suggest that the genetic variants —SNPs, indels, and gene presence-absence polymorphisms —across A. fumigatus isolates may provide evidence of distinct populations of A. fumigatus (10, 17)." 1044 1830 W4283728280.pdf 10 5 separator 0.98783535 ¶ 1830 1832 W4283728280.pdf 10 6 text 0.9953508 "We investigated the distribution of genes with functional associations with relevant pathways investigated in A. fumigatus studies in the PanOrtho genome, focusing on important mechanisms signi ficant to the phenotypic differentiation of isolates (see supplemental file 5 at https:// figshare.com/articles/dataset/Examination_of_genome-wide_ortholog_variation_in _clinical_and_environmental_isolates_of_the_fungal_pathogen_Aspergillus_fumigatus/" 1832 2283 W4283728280.pdf 10 7 separator 0.7060451 ¶ 2283 2285 W4283728280.pdf 10 8 text 0.99961895 "19873927 ). Our analysis revealed extensive variation in copy number among genes encoding GPCRs, phosphatases, ABC transporters, kinases, TF, MSF transporters, and proteins important for conidiation, virulence, and secondary-metabolite production (Fig. 2A ). Notwithstanding these differences, gene copy number per orthogroup did not differ between clinical andenvironmental isolates." 2285 2676 W4283728280.pdf 10 9 separator 0.98739684 ¶ 2676 2678 W4283728280.pdf 10 10 text 0.9994117 "A. fumigatus produces a variety of secondary metabolites (SM) and ef flux pumps that s e r v ea sd e f e n s es y s t e m s( 4 5 ,4 6 ) .I nf u n g i ,t h eg e n e si np a t h w a y st h a ts y n t h e s i z eS Ma r e typically located next to each other in the genome and organized in contiguous gene clus- ters (BGC) (6, 47 –49). The gliotoxin BGC impacts A. fumigatus virulence and is widely pro- duced by Aspergillus species (50, 51). Here, we observed the conservation of the gliotoxin BGC across the PanOrtho genome (Fig. 2B). However, other BGCs, such as fumitremorgin, presented heterogeneity with regard to the genetic arrangement of BGCs within species (50), an observation that is typi fied by the total absence of these genes in the environmental isolate B-1-70s-1 (see supplemental file 5 at https:// figshare.com/articles/dataset/Examination" 2678 3546 W4283728280.pdf 10 11 paratext 0.8424085 "¶ _of_genome-wide_ortholog_variation_in_clinical_and_environmental_isolates_of_the_fungal _pathogen_Aspergillus_fumigatus/19873927" 3546 3679 W4283728280.pdf 10 12 separator 0.98882675 ¶ 3679 3681 W4283728280.pdf 10 13 text 0.99961036 "). Of the genes belonging to BGCs, 27 presented significant variation in species distribution in the PanOrtho genome (Fig. 2B ). All genes from the helvolic acid BGC were absent from isolate CNM-CM8812. All genes in BGC 4, predicted to produce a fusarielin-like metabolite, were classi fied as accessories and are absent in differ- ent isolates, such as A1163 (ASM15014v1), which lost all genes from this BGC. The fumitre- morgin BGC, cluster 29, is present in a unique isolate (Afu343) with two copies of all genes of the BGC. Of note, our analysis examined the presence and absence of genes encoded in BGCs, but further examination of physical clustering is warranted. Nonetheless, our findings corroborated previous descriptions of variation among BGCs within this species (6 –8)." 3681 4478 W4283728280.pdf 10 14 separator 0.9886373 ¶ 4478 4480 W4283728280.pdf 10 15 text 0.9970614 "The genetic diversity across species in virulence and drug resistance mechanisms has been extensively reviewed (43, 46, 52). Among clinical isolates of Aspergillus species, species- and isolate-speci fic polymorphisms were reported in the 14 a-sterol demethylase gene cyp51A (Afu4g06890) and in the 1,3-beta-glucan synthase catalytic subunit gene fks1,w h i c h are target genes for azoles and echinocandins, respectively (7, 14, 42). We observed no variation in gene copy number for cyp51A (Afu4g06890; orthogroup OG0003434),Genomic Conservation among A. fumigatus Isolates" 4480 5064 W4283728280.pdf 10 16 paratext 0.9682193 "mBio Month YYYY Volume XX Issue XX 10.1128/mbio.01519-22 11 Downloaded from https://journals.asm.org/journal/mbio on 02 August 2022 by 37.223.121.252." 5064 5219 W4283728280.pdf 10 17 separator 0.9957975 ¶ 5219 5221 W4283728280.pdf 10 0 paratext 0.9805908 "Asian Journal of Social Science Research (e -ISSN: 2600 -9706) Volume 5, Issue 1, 2023 DOI: https://doi.org/ 10.5281/zenodo.8088938" 0 139 W4382335135.pdf 2 1 separator 0.58854204 ¶ 141 143 W4382335135.pdf 2 2 paratext 0.7589101 ¶ 45 145 150 W4382335135.pdf 2 3 separator 0.98621166 ¶ 151 153 W4382335135.pdf 2 4 text 0.7910634 "media convergence. By studying the transformation of television programs in this specific case, valuable insights can be gained that may inform and inspire other television stations in China and beyond." 154 363 W4382335135.pdf 2 5 separator 0.9814911 ¶ 365 367 W4382335135.pdf 2 6 title 0.9929509 LITERATURE REVIEW 367 385 W4382335135.pdf 2 7 separator 0.995535 ¶ 387 389 W4382335135.pdf 2 8 text 0.99964875 "The t ransformation of television programs in media convergence has been a subject of extensive research and scholarly inquiry in recent years. With the rapid advancement of new media technologies and the changing media landscape, television stations worldwide h ave been compelled to adapt and innovate to stay relevant in an increasingly digital and interconnected world. This literature review aims to provide an overview of the existing research conducted between 2020 and 2022, focusing on the transformation of te levision programs within the context of media convergence, specifically emphasizing the case study of Shanxi Radio and Television Station in China." 389 1078 W4382335135.pdf 2 9 separator 0.9788017 ¶ 1080 1082 W4382335135.pdf 2 10 text 0.9997294 "As a theoretical framework, media convergence has gained significant attention in the study of media industr ies and their transformation. Scholars have highlighted the blending and integration of various media platforms, including television, the internet, and mobile devices, as key drivers of change in the television landscape. According to Jenkins (2014), medi a convergence encompasses both technological and cultural shifts, resulting in the convergence of content, distribution, and audience engagement. This convergence has led to the transformation of television programs, affecting their content, production pro cesses, and modes of consumption." 1082 1757 W4382335135.pdf 2 11 separator 0.9819335 ¶ 1759 1761 W4382335135.pdf 2 12 text 0.99966127 "One prominent aspect of the transformation of television programs in media convergence is the reimagining and diversifying content. Scholars have explored the changes in storytelling techniques, narrative structures, and thematic elements in television programming. Li and Liang (2021) argue that media convergence has facilitated the creation of immersive and interactive content, blurring the boundaries between traditional television shows and online platfor ms. This shift has allowed for more personalized and participatory viewing experiences as viewers increasingly engage with television programs through social media platforms, interactive apps, and user -generated content." 1761 2466 W4382335135.pdf 2 13 separator 0.9855546 ¶ 2468 2470 W4382335135.pdf 2 14 text 0.99974567 "Adopting new technologies has playe d a crucial role in transforming television production processes. Researchers have examined the impact of digital technologies, such as high -definition cameras, virtual reality, and augmented reality, on the production and presentation of television progra ms. Langa et al. (2021) suggest that integrating these technologies has enabled television stations to enhance the visual quality of their programs, create immersive viewing experiences, and experiment with innovative storytelling techniques. Additionally, data analytics and artificial intelligence use in content recommendation and audience targeting have become increasingly prevalent in the television industry (Anantrasirichai & Bull, 2022)." 2470 3235 W4382335135.pdf 2 15 separator 0.98783743 ¶ 3237 3239 W4382335135.pdf 2 16 text 0.99967664 "Television programs' transformation in media convergence is also shaped by policy and regulatory frameworks. Scholars have examined media convergence's regulatory challenges and opportunities, particularly in China. Taeihagh (2021) discusses how Chinese media regulators have responded to the changing media landscape, hi ghlighting the need for flexible and adaptive policies that foster innovation while ensuring social stability. Policy changes, such as the loosening of restrictions on online video platforms and the promotion of cross -media collaborations, have influenced the strategies and practices of television stations like Shanxi Radio and Television Station." 3239 3933 W4382335135.pdf 2 0 paratext 0.9570929 "Singh KD et al. Int Surg J . 201 7 Apr;4(4):1394 -1397 ¶ International Surgery Journal | April 2017 | Vol 4 | Issue 4 Page 1395" 0 337 W4298847199.pdf 1 1 title 0.63295376 338 339 W4298847199.pdf 1 2 text 0.9934419 "progressive vision loss due to cataract for five years and subsequent ly she developed carcinoma of the right breast (Stage IIIB at presentation) (Figure 1). Patient had no history of trauma to eyes, watering, glares, floaters or redness of eyes; nor did she have diabetes mellitus or any other metabolic abnormality. We lost the patient as she died in an unfortunate road traffic accident. However, this interesting possible association motivated us to seek out the link between these two disease entities viz. breast cancer and early -onset cataract ." 339 919 W4298847199.pdf 1 3 separator 0.98965424 ¶ ¶ 920 926 W4298847199.pdf 1 4 caption 0.99568045 "Figure 1: Right breast mass with bilateral early -onset cataract at presentation ." 926 1013 W4298847199.pdf 1 5 separator 0.9959755 ¶ 1014 1016 W4298847199.pdf 1 6 title 0.9918313 METHODS 1016 1024 W4298847199.pdf 1 7 separator 0.994166 ¶ 1026 1028 W4298847199.pdf 1 8 text 0.99622554 "A comprehensive online English literature search was done using various electronic search databases including “Med -line”, “PubMed”, “Scopus”, “Web of Science” and “Google Scholar”. Different search terms related to pathogenesis of carcinoma breast and cataract were used like “pathogenesis of carcinoma breast”, “pathogenesis of cataract”, “pathogenesis of early onset cataract”, “cancer and cataract”, “association between carcinoma breast and cataract”, and “link between cancer and early onset cataract”. An advanced search was also carried out by combining all search fields in keywords, abstracts and/or titles. Using these search terms, appropriate articles were selected for a comprehensive revie w. Investigation of literature was further supplemented by searching the referenced articles created by original investigators. Finally, all the selected articles were confirmed for duplications a nd excluded, if it was observed ." 1028 2012 W4298847199.pdf 1 9 separator 0.9965656 ¶ 2013 2015 W4298847199.pdf 1 10 title 0.9922055 RES ULT S 2015 2025 W4298847199.pdf 1 11 separator 0.9949014 ¶ 2026 2028 W4298847199.pdf 1 12 text 0.999439 "Early -onset catarac t (EOC) is thought to be due to insufficient anti -oxidative function.2,3 Carcinogenesis is similarly related to oxidative stress and oxidative damage.4 This anti -oxidative insufficiency may occur as a result of faulty anti -oxidative and/or deoxyribonucleic acid (DNA) repair or due to overproduction of reactive oxygen species (ROS) which leads to oxidative damage to cellular macromolecules, genomic instability and uncontrolled cell proliferation.4 This similar mechanism might explain the propensity of develo pment of certain cancers in patients with EOC. The mechanisms which we found in our literature review for the possible association between BC and EOC included metabolic syndrome, action of reactive oxygen species, genetic polymorph isms and environmental fa ctors ." 2028 2871 W4298847199.pdf 1 13 separator 0.9944806 ¶ 2873 2875 W4298847199.pdf 1 14 title 0.99099207 DISCUSSION 2875 2886 W4298847199.pdf 1 15 separator 0.99404156 ¶ 2888 2890 W4298847199.pdf 1 16 text 0.9987694 "We describe here the possible mechanisms linking EOC with BC which we found during our literature review." 2890 2999 W4298847199.pdf 1 17 separator 0.6862823 ¶ 3000 3002 W4298847199.pdf 1 18 text 0.97578645 "Table 1 summarizes all the studies which explain the various possible links between EOC and BC." 3002 3101 W4298847199.pdf 1 19 separator 0.9960861 ¶ 3103 3105 W4298847199.pdf 1 20 title 0.7746164 "Table 1: Studies explaining the various possible links between Early -onset cataract and Breast cancer ." 3105 3213 W4298847199.pdf 1 21 separator 0.990887 ¶ 3214 3216 W4298847199.pdf 1 22 title 0.8825522 "Possible links between early - onset cataract and breast cancer Studies explaining the possible mechanisms" 3216 3340 W4298847199.pdf 1 23 separator 0.98793 ¶ 3342 3344 W4298847199.pdf 1 24 title 0.77236956 "Metabolic Syndrome" 3344 3366 W4298847199.pdf 1 25 text 0.9629994 "Forte et al 6- Diabetes and obesity are linked closely and both in -turn are associated with an increased incidence of solid tissue cancers. " 3367 3520 W4298847199.pdf 1 26 separator 0.48663577 ¶ 3520 3521 W4298847199.pdf 1 27 text 0.95942605 "Tan et al8- Metabolic syndrome is associated with all three types of cataracts. Paunksnis et al9- Increased odds of cataract formation in middle -aged females with arterial hypertension, obesity and hypertriglyceridemia." 3521 3759 W4298847199.pdf 1 28 separator 0.9953123 ¶ 3761 3763 W4298847199.pdf 1 29 title 0.9540785 "Reactive Oxygen" 3763 3782 W4298847199.pdf 1 30 separator 0.8579186 ¶ 3783 3785 W4298847199.pdf 1 31 text 0.9880037 "Species Klaunig et al4, Martinez -Outschoorn et al13- ROS alter gene expression patterns and thus contribute to carcinogenesis through oxidative stress in fibroblasts which then proliferate uncontrollably." 3785 4004 W4298847199.pdf 1 32 separator 0.6683502 ¶ 4006 4008 W4298847199.pdf 1 33 text 0.9946916 "Augusteyn et al14- ROS lead to lens opacification through oxidative damage to lens proteins." 4008 4107 W4298847199.pdf 1 34 separator 0.5042033 ¶ 4109 4111 W4298847199.pdf 1 35 text 0.9901848 "West et al15- Oxidative damage associated with ultraviolet light plays a key role in the development of cataracts." 4111 4232 W4298847199.pdf 1 36 separator 0.99398994 ¶ 4234 4236 W4298847199.pdf 1 37 title 0.7028201 "Genetic Factors" 4236 4255 W4298847199.pdf 1 38 text 0.99391246 "Saadat et al17- Increased incidence of cataract in subjects with the null genotype of GSTM1." 4256 4355 W4298847199.pdf 1 39 separator 0.48367718 4357 4358 W4298847199.pdf 1 40 text 0.9840645 "¶ Sohail et al19- Polymorphisms of GSTM1, GSTT1, GSTP1 and GSTO2 have been shown to be associated with increased risk of developing breast cancer." 4358 4513 W4298847199.pdf 1 41 separator 0.99292684 ¶ 4515 4517 W4298847199.pdf 1 42 title 0.69878435 Environmental ¶ 4517 4534 W4298847199.pdf 1 43 text 0.98321044 "Factors Swanson et al21- Increased use of glyphosate in the United States has been demonstrated with increase in the incidence and/or death rate of multiple diseases (including cataract) and several cancers (like breast cancer, liver cancer etc.)." 4534 4798 W4298847199.pdf 1 44 separator 0.8264124 ¶ 4800 4802 W4298847199.pdf 1 45 text 0.99142283 "Stout et al22- Glyphosate induced a statistically significant cataractous lens formation in male as well as female rats." 4802 4929 W4298847199.pdf 1 46 separator 0.790316 ¶ 4931 4933 W4298847199.pdf 1 47 text 0.98634255 "Séralini et al25- Female rats fed with GM maize treated with glyphosate had very high propensity of developing mammary fibroadenomas and adenocarcinomas" 4933 5095 W4298847199.pdf 1 48 separator 0.60805404 ¶ 5097 5099 W4298847199.pdf 1 49 text 0.8975878 "ROS - reactive oxygen species; GST - glutathione S -transferase; GM - genetically modified ." 5099 5195 W4298847199.pdf 1 50 separator 0.9957725 ¶ 5196 5198 W4298847199.pdf 1 0 separator 0.79697156 ¶ 1 2 W4235272072.pdf 0 1 paratext 0.87701863 1 2 4 W4235272072.pdf 0 2 separator 0.74668235 ¶ 4 6 W4235272072.pdf 0 3 title 0.9624055 "GREEN ECONOMY WORKSHOP : MEMPERSIAPKAN WIRAUSAHA MUDA YANG BERWAWASAN LINGKUNGAN DI SMKN 3 BANJARMASIN" 6 115 W4235272072.pdf 0 4 separator 0.9773029 ¶ ¶ 115 121 W4235272072.pdf 0 5 title 0.7475089 Green Economic Workshop : Preparing Environmental Friendly Young Entrepreneurship 121 203 W4235272072.pdf 0 6 text 0.3696308 ¶ ¶ 204 210 W4235272072.pdf 0 7 title 0.5267935 In SMKN 3 Banjarmasin 210 232 W4235272072.pdf 0 8 separator 0.94833404 ¶ ¶ 233 239 W4235272072.pdf 0 9 contact 0.9934677 "Oleh. ¶ Rizka Zulfikar, S.Tp, MM 1] , Prihatini Ade Mayvita, SE, MM 2] ¶ 1] 2] Fakultas Ekonomi Universitas Islam Kalimantan MAB – ¶ Banjarmasin ¶ 1] rizkazulfikar@gmail.com , 2] ademayvita@gmail.com" 239 480 W4235272072.pdf 0 10 separator 0.82348436 480 481 W4235272072.pdf 0 11 contact 0.51077235 ¶ 481 482 W4235272072.pdf 0 12 separator 0.9532968 ¶ ¶ 484 490 W4235272072.pdf 0 13 title 0.93217933 Abstract 490 499 W4235272072.pdf 0 14 separator 0.85147744 ¶ 499 504 W4235272072.pdf 0 15 text 0.9959427 "¶ At present, environmental issues is an important concern for the whole world along with the many problems that threated the environment such as global warming, ozone layer depletion, and also water and soil pollution . The implementation of the green econ omy as a form of public awareness of how importance environment is to the future has been intensively conducted. ¶ School can be a right media, a comfortable and dynamic system for students to develop good knowing, good filling and good acting based on the environment. ¶ The small number of environmental knowledge in educational subject received by students at SMKN 3 Banjarmasin, made the students mindset of environmental and motivate to apply the concepts of green economy in their environment has not been e stablished and it will be a priority issue agreed between proposer and partners. ¶ Implementation of this community development activities had taken the form of workshops and carried out with lectures, discussions and audio visual media presentation. Lectur es and discussions had conducted for the subjects (a) The definition of Green Economy and government policies relating to green economic concepts, (b) The purpose of green economy concepts, (c) Knowing the environmental damage due to non - application of gre en economy. (d) How to Applicated the green economic concepts in the student environment and society, (e) Simply application of the 3 pillars of the green economy (Reuse, Reduce and Recycle), (f) Introduction and empower the business opportunities in the era of green economy, (g) Introduction the practice of making edible water bottle as environmental friendly products and as an alternative replaced product for plastic cups used. ¶ The Evaluation technic of this community development activities carried out t o assess the succestiveness of this event had conducted in the form of giving pre and post test related the subject matter had discussed in this activity. This test is to determine the effect of this community development activities to give added value on ¶ knowledge and motivation of all participants to preparing the sudents as an e nvironmental friendly young entrepreneurship ." 504 2824 W4235272072.pdf 0 16 separator 0.7774295 "¶ ¶" 2824 2834 W4235272072.pdf 0 17 text 0.8794186 "Keywords ¶ : Green Economy, Entrepreneurship, Environmental Friendly." 2834 2910 W4235272072.pdf 0 18 separator 0.99172187 ¶ ¶ 2910 2916 W4235272072.pdf 0 19 title 0.9863125 Abstrak 2916 2924 W4235272072.pdf 0 20 separator 0.97113955 ¶ ¶ 2925 2931 W4235272072.pdf 0 21 text 0.9954476 "Isu lingkungan hidup hingga saat ini menjadi perhatian penting bagi seluruh dunia seiring dengan banyaknya masalah yang mengancam lingkungan hidup manusia seperti global warming ," 2931 3119 W4235272072.pdf 0 0 paratext 0.97316855 "Geosistemy perehodnykh zon = Geosystems of Transition Zones / Геосист емы переходных зон Content is available under the Creative Commons Attribution 4.0 International License (CC BY 4.0) 2021, vol. 5, No. 2, pp. 153–166 URL: http://journal.imgg.ru/archive.html ; https://elibrary.ru/title_about.asp?id=64191 https://doi.org/10.30730/gtrz.2021.5.2.153 -166" 0 377 W3181928708.pdf 0 1 separator 0.9759315 ¶ 378 380 W3181928708.pdf 0 2 title 0.98062813 "Study of fractured reservoirs during geological exploration in the north -eastern part of the Sakhalin Island" 380 494 W3181928708.pdf 0 3 separator 0.9898317 ¶ 496 498 W3181928708.pdf 0 4 contact 0.8746691 "Yuri V. Kostrov1, yvkostrov@snipi.rosneft.ru Vladislav A. Degtyarev1,2, https ://orcid .org/0000 -0001 -8922 -3654 , degtyarevvladislav96@yandex Anton V . Marinin3, https ://orcid .org/0000 -0002 -1099 -6492 , marinin@yandex.ru Eduard K. Khmarin1, ekkhmarin @snipi.rosneft .ru Pavel A. Kamenev2, https" 498 818 W3181928708.pdf 0 5 bibliography 0.50347805 :// 818 822 W3181928708.pdf 0 6 contact 0.6571279 orcid .org/0000 -0002 -9934 -5855 , p.kamenev @imgg .ru 822 877 W3181928708.pdf 0 7 separator 0.97705567 ¶ 878 880 W3181928708.pdf 0 8 contact 0.970765 "1LLC “RN -SakhalinNIPImorneft”, Yuzhno -Sakhalinsk, Russia 2Institute of Marine Geology and Geophysics, FEB RAS, Yuzhno -Sakhalinsk, Russia 3Schmidt Institute of Physics of the Earth , RAS, Moscow, Russia" 880 1093 W3181928708.pdf 0 9 separator 0.9900608 ¶ 1095 1097 W3181928708.pdf 0 10 table 0.4468814 Abstract PDF ENG Резюме PDF RUS Full text 1097 1167 W3181928708.pdf 0 11 paratext 0.4088736 PDF RUS 1168 1176 W3181928708.pdf 0 12 separator 0.99556166 ¶ 1178 1180 W3181928708.pdf 0 13 text 0.9840286 "Abstract. During a geological fieldworks in the northeast of Sakhalin Island in order to study the siliceous deposits of the Pilskaya formation and to develop a technique for locating oil deposits in unconventional fractured reservoirs, natural outcrops of Cenozoic deposits on the Schmidt Peninsula and in the Pogranichny depression were studie d." 1180 1535 W3181928708.pdf 0 14 separator 0.66464245 ¶ 1536 1538 W3181928708.pdf 0 15 text 0.9991101 "Samples were taken for analytical studies (geomechanical, geochemical, lithological, etc.), structural forms (folds, minor faults, slickensides, tension gashes, joints, shear fractures), which are indicators of tectonic deformations of the rock massive, were studied. It is shown that the intensity of fracturing strongly depends on the lithology, the position of the observation point relative to disjunctive and/or plicative structures. The direction of the joints varies depending on the position relative to the elements of the local folds and on the position of the block (with a small - block structure). According to the results of field observations it is shown, that the zone of intense dislocations has an extremely insignificant thickness usually the first tens of meters. An extremely nonuniformity of the stress field in the vicinity of the Pogranichniy depression is noted, which is reflected in the nature of the dipping planes, structural patterns and parageneses. In the northern part of the syncline, nume rous flowing oil shows associated with open fracturing are identified, which obviously indicates the extension regime that continues up to this day ." 1538 2740 W3181928708.pdf 0 16 separator 0.9949229 ¶ 2741 2743 W3181928708.pdf 0 17 paratext 0.68002665 Keywords: 2743 2753 W3181928708.pdf 0 18 separator 0.80446696 ¶ 2755 2757 W3181928708.pdf 0 19 paratext 0.28811416 unconventional reservoirs 2757 2783 W3181928708.pdf 0 20 text 0.283597 , si 2783 2787 W3181928708.pdf 0 21 paratext 0.25984147 liceous 2787 2794 W3181928708.pdf 0 22 text 0.29288492 deposit 2794 2802 W3181928708.pdf 0 23 paratext 0.25265023 s, 2802 2804 W3181928708.pdf 0 24 text 0.3007812 tec 2804 2808 W3181928708.pdf 0 25 paratext 0.27042416 tonic stress 2808 2820 W3181928708.pdf 0 26 text 0.26240456 , de 2820 2824 W3181928708.pdf 0 27 paratext 0.28712088 formations, 2824 2835 W3181928708.pdf 0 28 text 0.3016585 ¶ 2837 2839 W3181928708.pdf 0 29 paratext 0.2754313 2839 2840 W3181928708.pdf 0 30 text 0.2996645 slick 2840 2845 W3181928708.pdf 0 31 paratext 0.2795275 ensides, 2845 2853 W3181928708.pdf 0 32 text 0.30322105 fractur 2853 2861 W3181928708.pdf 0 33 paratext 0.28392664 ing, 2861 2865 W3181928708.pdf 0 34 text 0.2894447 ge 2865 2868 W3181928708.pdf 0 35 paratext 0.34416446 ological fieldwork, Sakhalin Island 2868 2903 W3181928708.pdf 0 36 separator 0.99267745 ¶ 2905 2907 W3181928708.pdf 0 37 bibliography 0.91210955 "For citation: Kostrov Yu. V., Degtyarev V.A., Marinin A.V., Khmarin E.K., Kamenev P.A. Study of fractured reservoirs during geological exploration in the north -eastern part of the Sakhalin Island. Geosistemy perehodnykh zon = Geosystems of Transition Zones , vol. 5, no. 2, pp. 153–166. (In Russ ., abstr . in Engl.). https ://doi.org/10.30730/ g" 2907 3263 W3181928708.pdf 0 38 paratext 0.6179263 trz.2021.5.2.153 -166 3263 3284 W3181928708.pdf 0 39 separator 0.9835257 ¶ 3285 3287 W3181928708.pdf 0 40 bibliography 0.98161 "Для цитиро вания: Костров Ю.В., Дегтярев В.А., Маринин А.В., Хмарин Э.К., Каменев П.А. Изучение трещинных коллекторов при проведении геологоразведочных работ в северо -восточной части о. Сахалин. Геосистемы переходных зон , 2021, т. 5, No 2, с. 153 –166. https ://doi.org/10.30730/ gtrz.2021.5.2.153 -166" 3287 3598 W3181928708.pdf 0 41 separator 0.98147845 ¶ 3599 3601 W3181928708.pdf 0 42 paratext 0.5312994 References 3601 3612 W3181928708.pdf 0 43 separator 0.99374515 ¶ 3614 3616 W3181928708.pdf 0 44 bibliography 0.9976785 "1. Voeykova O.A., Nesmeyanov S.A., Serebryakova L.I. 2007. Neotektonika i aktivnye razlomy Sakhalina [Neotectonics and active faults of Sakhalin ]. Moscow: Nauka, 187 p. (In Russ.)." 3616 3806 W3181928708.pdf 0 45 separator 0.94973516 ¶ 3808 3810 W3181928708.pdf 0 46 bibliography 0.9978893 "2. Gal’versen V.G., Evseev S.V., Konovalenko A.A., Khaybullina G.A. (comp.) 2016. [State geological map of Russian Federation on a scale of 1:200 000. Sakhalin series. Sheet M -54-XVIII (Pogranichnoe) ]: [Explanatory note. Second editi on]." 3810 4055 W3181928708.pdf 0 47 separator 0.5896038 ¶ 4056 4058 W3181928708.pdf 0 48 bibliography 0.9961197 "Moscow: Moskovskiy filial FGBU «VSEGEI», 187 p. [Recommend for print by Rosnedra Scientific editorial board, December 1, 2009]. (In Russ.)." 4058 4201 W3181928708.pdf 0 49 separator 0.9617239 ¶ 4203 4205 W3181928708.pdf 0 50 bibliography 0.99773043 3. Geology of USSR . Vol. 33. Sakhalin Island . Geological description (ed. V.N. Vereshchagin). 1970. Moscow: Nedra, 432 p. 4205 4332 W3181928708.pdf 0 51 separator 0.9576386 ¶ 4334 4336 W3181928708.pdf 0 52 bibliography 0.9979226 "4. Gladenkov Yu.B., Bazhenova O.K., Grechin V.I., Margulis L.S., Sal’nikov B.A. 2002. [The Cenozoic of Sakhalin and its petroleum potential ]. Moscow: GEOS, 225 p. (In Russ.)." 4336 4516 W3181928708.pdf 0 53 separator 0.9516144 ¶ 4518 4520 W3181928708.pdf 0 54 bibliography 0.99771345 "5. Dymovich V.A., Evseev S.V., Evseev V.F. et al. (comp.) 2016. [State geologic al map of Russian Federation on a scale of 1:1 000 000. State geological map of Russian Federation on a scale of 1:1 000 000. Third generation. Far East series." 4520 4765 W3181928708.pdf 0 55 separator 0.7793777 ¶ 4766 4768 W3181928708.pdf 0 56 bibliography 0.9888676 "Sheet M -54 (Aleksandrovsk -Sakhalinskiy) ]: [Explanatory note]. Saint Petersburg: Kartografi chesk aya fabrika VSEGEI, 599 p. (In Russ.). https://www.vsegei.ru/ru/info/pub_ggk1000 -3/Dalnevostochnaya/m -54.php" 4768 4982 W3181928708.pdf 0 0 paratext 0.97495425 "Materials Today Communications 31 (2022) 103654 6M.M. Allaham et al." 0 70 W4280564096.pdf 5 1 separator 0.97011256 ¶ 70 72 W4280564096.pdf 5 2 text 0.987403 "name for v( x), so it is provisionally being called the principal field emission special mathematical function (but ‘‘v’’ for short). Previously, the mathematics of ‘‘v’’ has been formulated in terms of theNordheim parameter y, which (it can be shown) is equal to +√ x." 72 350 W4280564096.pdf 5 3 separator 0.83582574 ¶ 350 352 W4280564096.pdf 5 4 text 0.9995687 "It can be argued that, since xis the natural variable for use in the mathematics, the legacy practice of using the Nordheim parameter y should (from the strictly mathematical point of view) now be regarded asmathematically perverse . In particular, it is NOT normal mathematical practice to look for a solution to a differential equation in terms of a function of the SQUARE ROOT of the independent variable in the equation. Normal practice is to look for a solution that USES the independent variable in the differential equation." 352 898 W4280564096.pdf 5 5 separator 0.8135129 ¶ 898 900 W4280564096.pdf 5 6 text 0.9995615 "It has also been argued that, in fact, the natural variable to use in an MG-type theory of current densities is the characteristic scaled- fieldfCdefined by Eq. (6), rather than the legacy convention of using the Nordheim parameter y. Both conventions should continue to be permissible, at least for the time being, but it can be argued that it is likely that experimentalists will in fact find that using fCis a more powerful and flexible approach, particularly when discussing current–voltage measurements and theory." 900 1434 W4280564096.pdf 5 7 separator 0.90375715 ¶ 1434 1436 W4280564096.pdf 5 8 text 0.999453 "Thus, our strongly recommended ‘‘21st Century approach’’ is that the special mathematical function v( x) should be applied to MG theory, as for example set out in Eq. (8), by setting vF= v(x=fC). The mathematical proof that this is a correct procedure is lengthy and is currently spread over several papers, using a variety of notations. A short argument that this is correct is as follows. In the legacy approach it has been shown that ‘‘ y’’ in the modelling is the same parameter as ‘‘y’’ in the basic mathematics. It follows that ‘‘ y2’’ in the modelling is the same as ‘‘ y2’’ in the basic mathematics. It follows that if we replace ‘‘y2’’ in the mathematics by xand ‘‘y2’’ in the modelling by fC, then the substitution procedure described above is a procedure compatible with the legacy approach. There remains a need for a full proper proof to be published in a single tutorial-type paper." 1436 2357 W4280564096.pdf 5 9 separator 0.9430934 ¶ 2357 2359 W4280564096.pdf 5 10 text 0.999305 "The alternative approach is the legacy modelling convention in which we write vF= v(x=y2). Eq. (8) is written using the symbol vFin order to allow either convention to be used." 2359 2540 W4280564096.pdf 5 11 separator 0.9869828 ¶ 2540 2542 W4280564096.pdf 5 12 text 0.99414265 "Scaled planar FE equations . A further consequence of introducing the parameter fCis that this allows the development of useful so- called scaled equations for kernel current densities. For the SN barrier, work-function-dependent scaling parameters for the exponent and pre- exponential, respectively, can be defined (using FE universal constants defined earlier) by " 2542 2920 W4280564096.pdf 5 13 separator 0.7969945 ¶ 2920 2921 W4280564096.pdf 5 14 math 0.9300733 "η(φ)≡bc2 Sφ−1∕2, (10) θ(φ)≡ac−4 Sφ3. (11)" 2921 2969 W4280564096.pdf 5 15 separator 0.9278355 ¶ 2969 2971 W4280564096.pdf 5 16 text 0.9627609 "Algebraic manipulation of Eq. (8), using these equations and also Eq. (6), yields the scaled-format equation for the kernel current density for the SN barrier, namely JSN" 2971 3148 W4280564096.pdf 5 17 math 0.8945182 "¶ kC≡θf2 Cexp[ −v(fC)⋅η fC] , (12)" 3148 3191 W4280564096.pdf 5 18 separator 0.9690958 ¶ 3191 3193 W4280564096.pdf 5 19 text 0.9981305 "Here, and below, the dependence of ηandθon work-function is not normally shown explicitly, but the dependence of ‘‘v’’ on fCis now shown explicitly." 3193 3346 W4280564096.pdf 5 20 separator 0.7272439 ¶ 3346 3348 W4280564096.pdf 5 21 text 0.99894994 "A merit of this equation is that it contains only a single, direct, in- dependent variable. This makes mathematical manipulations, including differentiation, markedly easier." 3348 3527 W4280564096.pdf 5 22 separator 0.9166645 ¶ 3527 3529 W4280564096.pdf 5 23 text 0.99090594 "If this scaled equation is to be used to help interpret FE current– voltage measurements from electronically ideal systems, then a formula is needed that relates fCto the measured voltage Vm. This is achieved by using Eq. (21) below to define a parameter VmR, called the reference measured voltage (for the SN barrier), by VmR=FSN RζC, (13)whereζCis (for an electronically ideal system) a system-specific char- acterization constant called the characteristic voltage conversion length (VCL) . For an electronically ideal system modelled using a SN barrier, VmRis the measured voltage needed to pull the top of the SN barrier down to the Fermi level." 3529 4199 W4280564096.pdf 5 24 separator 0.98835653 ¶ 4199 4201 W4280564096.pdf 5 25 text 0.8510714 Applying a similar equation to the field-magnitude FCyields 4201 4261 W4280564096.pdf 5 26 separator 0.73311627 ¶ 4261 4263 W4280564096.pdf 5 27 math 0.9202165 "fC=FC FSN R=Vm∕ζC VmR∕ζC=Vm VmR. (14)" 4263 4309 W4280564096.pdf 5 28 separator 0.93072665 ¶ 4309 4311 W4280564096.pdf 5 29 text 0.9992769 "Thus, for an electronically ideal system, fCis also ‘‘scaled measured voltage’’ (and, for a LAFE, is also ‘‘scaled macroscopic field’’)." 4311 4450 W4280564096.pdf 5 30 separator 0.9812584 ¶ 4450 4452 W4280564096.pdf 5 31 text 0.9864297 "The ‘‘simple good approximation’’ for v (fC). As part of ‘‘21st Century’’ mathematical developments, several accurate (exactly equivalent) ex- pressions, and some high-quality mathematical approximations, have been developed for v( x). These are described elsewhere [25]. Of rel- evance here is the so-called simple good approximation vF06[25,26]:" 4452 4808 W4280564096.pdf 5 32 separator 0.9695133 ¶ 4808 4810 W4280564096.pdf 5 33 math 0.9430921 "v(fC) ≈ vF06= 1 −fC+1 6fCln(fC), (15)" 4810 4850 W4280564096.pdf 5 34 separator 0.89916825 ¶ 4850 4852 W4280564096.pdf 5 35 text 0.98908883 "Over the range 0⩽fC⩽1, where ‘‘v’’ takes values in the range 1≥v≥0, the maximum relative error in expression (15) is 0.33% and the maximum absolute error is 0.0024." 4852 5021 W4280564096.pdf 5 36 separator 0.7882141 ¶ 5021 5023 W4280564096.pdf 5 37 text 0.99391496 "If this expression is inserted into Eq. (12), algebraic re-arrangement leads to the expanded scaled format for the SN-barrier kernel current density, namely" 5023 5184 W4280564096.pdf 5 38 separator 0.500337 ¶ 5184 5186 W4280564096.pdf 5 39 math 0.89042735 "JSN kC≈θf(2−η∕6) Cexp [η] exp[ −η fC] . (16)" 5186 5241 W4280564096.pdf 5 40 separator 0.95739436 ¶ 5241 5243 W4280564096.pdf 5 41 text 0.97677094 "As shown below, this equation forms the basis for the construction of Murphy–Good plots." 5243 5334 W4280564096.pdf 5 42 separator 0.92407304 ¶ 5334 5336 W4280564096.pdf 5 43 text 0.9992934 "Note that the exponent exp [−η∕fC]also appears in the elemen- tary version of the 1928/29 FN FE equation. Thus, in this expanded scaled formulation, the whole of the difference between 1956 MG FE theory and elementary FE theory appears in the pre-exponential of the equations. This in turn affects the intercept of a data-analysis plot, and implies a need for accurate extraction of plot intercept values." 5336 5752 W4280564096.pdf 5 44 separator 0.99635065 ¶ 5752 5754 W4280564096.pdf 5 45 title 0.9932267 2.2. Data analysis plots and related issues 5754 5798 W4280564096.pdf 5 46 separator 0.9953776 ¶ 5798 5800 W4280564096.pdf 5 47 text 0.9995184 "Data input variables. As indicated above, our strong view is that by far the best choice for data input variables is to use the measured current and voltage and current {Im,Vm}. This is because, for both ideal and non-ideal FE systems, these data are experimental facts , and are therefore scientifically valid items of information. However, other plot-variables are found in FE literature." 5800 6201 W4280564096.pdf 5 48 separator 0.855111 ¶ 6201 6203 W4280564096.pdf 5 49 text 0.9904102 "For a LAFE, the macroscopic (or ‘‘LAFE-average’’) current density JM is defined by JM≡Im AM, (17) whereAMis the macroscopic or ‘‘footprint’’ area of the LAFE. This area AMcan be independently measured, so the macroscopic current density JMis a well-defined experimental parameter." 6203 6496 W4280564096.pdf 5 50 separator 0.8326199 ¶ 6496 6498 W4280564096.pdf 5 51 text 0.9992566 "Note that it is important that the subscript ‘‘M’’ (or ‘‘av’’) be added to the symbol for macroscopic current density. This is because, in real situations, emission comes only from the tips of individual emitters, and this ‘‘effective tip emission area’’ is only a small fraction of the ‘‘site area’’ (i.e., the footprint associated with a single emitter). Thus, the parameter JMis much smaller than the characteristic local emission current densities ( JC) discussed earlier, perhaps sometimes by a factor as much as 109. Formal ways of dealing with this situation are discussed below." 6498 7101 W4280564096.pdf 5 52 separator 0.9636963 ¶ 7101 7103 W4280564096.pdf 5 53 text 0.99935746 "In FE literature, this distinction between local current densities and macroscopic current densities is often not made, and the same symbol J(and the same name ‘‘current density’’) are used for both: for JMin diagrams and for JCin equations. This can lead to publication situations" 7103 7391 W4280564096.pdf 5 0 text 0.99964494 "Recently, the interaction of quantum emitters with light fields that exhibit spin-orbit interaction has been observed in the strongly confined optical modes of whispering- gallery-mode (WGM) resonators [20,21] and nanoscale waveguides [22–24]. This opens the route towards a new class of nonreciprocal devices in which the quantum state of the emitter controls the light propagation in nano- photonic waveguides [25–27]. Moreover, by optically addressing the quantum emitters, these devices could be programmed and actively reconfigured. Nowadays, quan- tum emitters, like single atom s, molecules, quantum dots, or color centers, can be prepared and manipulated withhigh precision. This should, therefore, allow bottom-up engineering of nonreciprocal components, like diodes and circulators, from their microscopic constituents." 0 855 W3099457041.pdf 1 1 separator 0.9768679 ¶ 855 857 W3099457041.pdf 1 2 text 0.99872595 "Here, we demonstrate low-loss silica nanophotonic waveguides with a strongly nonreciprocal transmission controlled by the internal state of spin-polarized atoms." 857 1023 W3099457041.pdf 1 3 separator 0.93023473 ¶ 1023 1025 W3099457041.pdf 1 4 text 0.9997152 "In a first experiment, an ensemble of atoms interacts with light guided in an optical nanofiber [28]. Here, each atom is weakly coupled to the waveguide. In a second experiment, the diode is controlled by a single atom that is strongly coupled to the waveguide by means of an ultrahigh-quality factor WGM bottle microresonator [20]. With the atomic ensemble, we measure an imbalance between the trans- missions in the forward and the backward direction as large as 8 dB for a few ten atoms, while it is 13 dB with the resonator-enhanced scheme. At the same time, the forward transmissions remain as high as 78% and 72%, respec- tively. Both experiments are carried out in an effective single-photon regime, i.e., a regime where every quantum emitter interacts with at most one photon at a time." 1025 1846 W3099457041.pdf 1 5 separator 0.9969095 ¶ 1846 1848 W3099457041.pdf 1 6 title 0.99363685 "II. CHIRAL INTERACTION BETWEEN ATOMS AND LIGHT" 1848 1897 W3099457041.pdf 1 7 separator 0.9946952 ¶ 1897 1899 W3099457041.pdf 1 8 title 0.94674015 A. Chiral photons in optical nanofibers 1899 1939 W3099457041.pdf 1 9 separator 0.98555285 ¶ 1939 1941 W3099457041.pdf 1 10 text 0.99967253 "Light that is transversally confined at the subwavelength scale can exhibit a significant polarization component along the propagation direction. The latter oscillates in phase quadrature with respect to the transverse components. Thus, confined quasilinearly polarized light exhibits a local spin that is transverse, i.e., orthogonal to the propagation direc- tion of the field [20,29] . This occurs, e.g., in the evanescent field that surrounds an optical nanofiber [23]; see Fig. 1(a)." 1941 2444 W3099457041.pdf 1 11 separator 0.97122455 ¶ 2444 2446 W3099457041.pdf 1 12 text 0.999644 "When the evanescent field propagates in the ðþzÞdirection, it is almost fully σ þpolarized if the yaxis is taken as the quantization axis. However, it is almost fully σ−polarized if it propagates in the ð−zÞdirection. This shows that photons in an evanescent field have chiral character: there is an inherent link between their local polarization and their propagation direction." 2446 2840 W3099457041.pdf 1 13 separator 0.9440724 ¶ 2840 2842 W3099457041.pdf 1 14 text 0.99939597 "In order to quantify this chiral character, we locally define an effective chirality χ1⁄4ε⋅ðk=jkj×erÞ, where eris the normal vector of the surface and kis the wave vector,ε1⁄4iðE/C3×EÞ=jEj2is the local ellipticity vector, or spin, and Eis the positive-frequency envelope of the electric field. In contrast to plane waves where this chirality is always zero,photons in evanescent fields have positive chirality, for boththeðþzÞ- and ð−zÞ-propagation directions." 2842 3307 W3099457041.pdf 1 15 separator 0.9969554 ¶ 3307 3309 W3099457041.pdf 1 16 title 0.993991 B. From chiral photons to nonreciprocal waveguides 3309 3360 W3099457041.pdf 1 17 separator 0.9948096 ¶ 3360 3362 W3099457041.pdf 1 18 text 0.9997298 "The chiral character of photons has been demonstrated in recent experiments by means of a polarization-dependentdirectional scattering by gold nanoparticles [30,31] , nano- tips[32], a silicon microdisk [33], quantum dots [22,24] , and atoms [23]. This chiral character and the resulting directional scattering are, however, not sufficient to realizenonreciprocal optical elements. For this purpose, Lorentzreciprocity [34]has to be broken. For example, in Faraday isolators, nonreciprocity stems from the change of the signof a magnetic field Bunder time reversal." 3362 3938 W3099457041.pdf 1 19 separator 0.9613356 ¶ 3938 3940 W3099457041.pdf 1 20 text 0.9996424 "In our experiment, we demonstrate that the chiral nature of photons can be exploited for the realization of an opticaldiode when the photons interact with spin-polarized atoms.Such atoms act as polarization-dependent scatterers, i.e., exhibit different interaction cross sections for σ þ- and σ−-polarized light. The resulting chiral interaction between the atoms and the guided light leads to nonreciprocal transmission as conceptually discussed in Refs. [25–27]." 3940 4417 W3099457041.pdf 1 21 separator 0.9700134 ¶ 4417 4419 W3099457041.pdf 1 22 text 0.99973464 "We note that the interaction cross sections for σþ- and σ−-polarized light, and thus their ratio, depend on the angular momentum quantum numbers of the atoms but noton the respective Landé gfactors [35]. The strength of the nonreciprocity is therefore independent of the magnitude ofthe involved magnetic moments and their associatedmagnetic fields. Our concept thus fundamentally differsfrom other isolator schemes because it relies on the atomicspin to break Lorentz reciprocity." 4419 4907 W3099457041.pdf 1 23 separator 0.988391 ¶ 4907 4909 W3099457041.pdf 1 24 caption 0.73718643 (a) (b) 4909 4917 W3099457041.pdf 1 25 separator 0.98894775 ¶ 4917 4919 W3099457041.pdf 1 26 caption 0.9712399 "FIG. 1. Chiral photons in evanescent fields coupled to spin- polarized atoms. (a) Polarization properties of the evanescentlight field that surrounds an optical nanofiber (gray). A light fieldthat propagates in the ðþzÞdirection and whose main polarization axis (double arrow) is along the xaxis is almost fully σ þpolarized (green solid arrows) in the ( y1⁄40) plane. If it propagates in the ð−zÞdirection, it is almost fully σ−polarized (blue dashed arrows). The quantization axis is chosen along y, i.e., orthogonal to the propagation direction. An atom (light blue sphere) placed ata distance rto the nanofiber surface couples to the evanescent field. (b) Relevant energy levels of the atom. The ground state jgi is coupled to the excited states je −1i,je0i, and jeþ1iviaσ−,π, andσþtransitions, respectively.CLÉMENT SAYRIN et al. PHYS." 4919 5779 W3099457041.pdf 1 27 bibliography 0.3919253 REV 5779 5783 W3099457041.pdf 1 28 caption 0.4227392 . X 5783 5786 W3099457041.pdf 1 29 bibliography 0.31515104 5,041036 5786 5795 W3099457041.pdf 1 30 caption 0.41978276 (2015) 5795 5802 W3099457041.pdf 1 31 separator 0.8779471 ¶ 5802 5804 W3099457041.pdf 1 32 paratext 0.9813635 041036-2 5804 5813 W3099457041.pdf 1 0 bibliography 0.9979321 "12-Gomes GM, Calixto AL, Santos FA, Gomes OM, D’Alpino PH, Gomes JC. Hardness of a bleaching-shade resin composite polymerized withdifferent light-curing sources. Braz Oral Res. 2006;20(4):337-41." 0 198 W1982220630.pdf 4 1 separator 0.98482305 ¶ 198 200 W1982220630.pdf 4 2 bibliography 0.9979717 "13-Kurachi C, Tuboy AM, Magalhaes DV , Bagnato VS. Hardness evaluation of a dental composite polymerized with experimental LED-based devices. Dent Mater. 2001;17(4):309-15." 200 375 W1982220630.pdf 4 3 separator 0.9798467 ¶ 375 377 W1982220630.pdf 4 4 bibliography 0.9980025 "14-Lovell LG, Newman SM, Donaldson MM, Bowman CN. The effect of light intensity on double bond conversion and flexural strength of a model,unfilled dental resin. Dent Mater. 2003;19(6):458-65." 377 572 W1982220630.pdf 4 5 separator 0.97814256 ¶ 572 574 W1982220630.pdf 4 6 bibliography 0.99784976 "15-Mathis RS, Ferracane JL. Properties of a glass-ionomer/resin-composite hybrid material. Dent Mater. 1989;5(5):355-8." 574 696 W1982220630.pdf 4 7 separator 0.9744822 ¶ 696 698 W1982220630.pdf 4 8 bibliography 0.99792504 "16-Micelli F, Maffezzoli A, Terzi R, Luprano V A. Characterization of the kinetic behavior of resin modified glass-ionomer cements by DSC, TMAand ultrasonic wave propagation. J Mater Sci Mater Med. 2001;12(2):151-6." 698 916 W1982220630.pdf 4 9 separator 0.9767611 ¶ 916 918 W1982220630.pdf 4 10 bibliography 0.99731237 "17-Miyazaki M, Hattori T, Ichiishi Y, Kondo M, Onose H, Moore BK. Evaluation of curing units used in private dental offices. Oper Dent.1998;23(2):50-4." 918 1072 W1982220630.pdf 4 11 separator 0.966614 ¶ 1072 1074 W1982220630.pdf 4 12 bibliography 0.9980095 "18-Mount GJ, Patel C, Makinson OF. Resin modified glass-ionomers: strength, cure depth and translucency. Aust Dent J. 2002;47(4):339-43." 1074 1213 W1982220630.pdf 4 13 separator 0.9774387 ¶ 1213 1215 W1982220630.pdf 4 14 bibliography 0.9976622 "19-Okte Z, Villalta P, Garcia-Godoy F, Garcia-Godoy F, Jr., Murray P. Effect of curing time and light curing systems on the surface hardness ofcompomers. Oper Dent. 2005;30(4):540-5." 1215 1400 W1982220630.pdf 4 15 separator 0.96708363 ¶ 1400 1402 W1982220630.pdf 4 16 bibliography 0.9979742 "20-Price RB, Ehrnford L, Andreou P, Felix CA. Comparison of quartz- tungsten-halogen, light-emitting diode, and plasma arc curing lights. JAdhes Dent. 2003;5(3):193-207." 1402 1574 W1982220630.pdf 4 17 separator 0.9675492 ¶ 1574 1576 W1982220630.pdf 4 18 bibliography 0.9978015 "21-Rafeek RN. The effects of heat treatment on selected properties of a conventional and a resin-modified glass ionomer cement. J Mater SciMater Med. 2008;19(5):1913-20." 1576 1748 W1982220630.pdf 4 19 separator 0.9770985 ¶ 1748 1750 W1982220630.pdf 4 20 bibliography 0.9978479 "22-Rueggeberg F. Contemporary issues in photocuring. Compend Contin Educ Dent. 1999;25:S4-S15." 1750 1847 W1982220630.pdf 4 21 separator 0.94327474 ¶ 1847 1849 W1982220630.pdf 4 22 bibliography 0.9980613 "23-Rueggeberg FA, Blalock JS, Callan RS. LED curing lights—what’s new? Compend Contin Educ Dent. 2005;26(8):586, 588, 590-1." 1849 1976 W1982220630.pdf 4 23 separator 0.96031964 ¶ 1976 1978 W1982220630.pdf 4 24 bibliography 0.99795526 "24-Rueggeberg FA, Caughman WF, Curtis JW Jr, Davis HC. Factors affecting cure at depths within light-activated resin composites. Am JDent. 1993;6(2):91-5." 1978 2135 W1982220630.pdf 4 25 separator 0.9616003 ¶ 2135 2137 W1982220630.pdf 4 26 bibliography 0.99784756 "25-Soh MS, Yap AU, Siow KS. The effectiveness of cure of LED and halogen curing lights at varying cavity depths. Oper Dent. 2003;28(6):707-15." 2137 2282 W1982220630.pdf 4 27 separator 0.9575696 ¶ 2282 2284 W1982220630.pdf 4 28 bibliography 0.9978398 "26-Tolosa MC, Paulillo LA, Giannini M, Santos AJ, Dias CT. Influence of composite restorative materials and light-curing units on diametricaltensile strength. Braz Oral Res. 2005;19(2):123-6." 2284 2478 W1982220630.pdf 4 29 separator 0.9561807 ¶ 2478 2480 W1982220630.pdf 4 30 bibliography 0.9978968 "27-Uhl A, Sigusch BW, Jandt KD. Second generation LEDs for the polymerization of oral biomaterials. Dent Mater. 2004;20(1):80-7." 2480 2611 W1982220630.pdf 4 31 separator 0.9574839 ¶ 2611 2613 W1982220630.pdf 4 32 bibliography 0.9975847 "28-Yap AU, Soh MS. Thermal emission by different light-curing units. Oper Dent. 2003;28(3):260-6." 2613 2713 W1982220630.pdf 4 33 separator 0.9366092 ¶ 2713 2715 W1982220630.pdf 4 34 bibliography 0.99783975 "29-Young AM. FTIR investigation of polymerization and polyacid neutralization kinetics in resin-modified glass-ionomer dental cements.Biomaterials. 2002;23(15):3289-95." 2715 2886 W1982220630.pdf 4 35 separator 0.9906677 ¶ 2886 2888 W1982220630.pdf 4 36 bibliography 0.9972488 154CEFALY D F G, MELLO L L C P de, WANG L, LAURIS J R P, D’ALPINO P H P 2888 2960 W1982220630.pdf 4 0 paratext 0.8575046 2437 0 5 W2805935222.pdf 272 1 title 0.9567133 . THE HAWAIIAN ACHIEvEMENT IN CoMPARATIvE PERSPECTIvE 5 58 W2805935222.pdf 272 2 separator 0.97597325 ¶ 58 60 W2805935222.pdf 272 3 text 0.9037628 "Bay. Cook was clearly associated with Lono, the most popular god in the family shrines of commoners as well as the focus of the makahiki." 60 201 W2805935222.pdf 272 4 paratext 0.41060302 54 201 203 W2805935222.pdf 272 5 separator 0.9879993 ¶ 204 206 W2805935222.pdf 272 6 text 0.9993566 "While there has been debate on whether Cook was viewed as Lono or a dangerous rival chief, there is no doubt that the memory of Cook–Lono was incorporated into the Hawaiian world view. Some days after Cook’s death, priests of Lono asked when ‘Erono’ would return." 206 476 W2805935222.pdf 272 7 separator 0.854982 ¶ 476 478 W2805935222.pdf 272 8 text 0.99663997 "55 When European contacts were renewed in 1786, the belief in the imminent return of Cook as Lono makua remained. Evidence from the 1790s and 1800s shows that Cook was incorporated into the Hawaiian pantheon and formally worshipped as a royal cult. His worship echoed that given to Lono makua during the makahiki." 478 798 W2805935222.pdf 272 9 separator 0.93305755 ¶ 798 800 W2805935222.pdf 272 10 text 0.99678826 "56 The English seaman William Mariner learnt from Hawaiians in Tonga during his forced residence there that: His bones (the greater part of which they still have in their possession!) they devoutly hold sacred. They are deposited in a house consecrated to a god, and are annually carried in a procession to many other consecrated houses, before each of which they are laid on the ground, and the priest returns thanks to the gods for having sent so great a man." 800 1270 W2805935222.pdf 272 11 separator 0.8466639 ¶ 1270 1272 W2805935222.pdf 272 12 text 0.789582 57 1272 1275 W2805935222.pdf 272 13 separator 0.9272008 ¶ 1275 1277 W2805935222.pdf 272 14 text 0.99937296 "This passage implies that Cook was perceived as an agent of Hawaiian gods. All great gods were foreign. European goods may also have been rationalised within the existing order as Mariner was also told that gods sent Cook ‘to civilise them’." 1277 1525 W2805935222.pdf 272 15 separator 0.8074633 ¶ 1525 1527 W2805935222.pdf 272 16 text 0.9984071 "58 Cook–Lono also seems to have been perceived as acting like a Hawaiian god. Over a decade after Cook’s death, Captain James Colnett found that two recent volcanic eruptions in the Kailua area of Hawai‘i Kona and a new illness were attributed to divine anger for the death of Cook. The association with volcanism relates to Lono’s association with lightning. As fire in the sky, lightning was a manifestation of Lono’s association with the family of Pele." 1527 1996 W2805935222.pdf 272 17 separator 0.7727288 ¶ 1996 1998 W2805935222.pdf 272 18 text 0.7291224 59 1998 2001 W2805935222.pdf 272 19 separator 0.97099936 ¶ 2001 2003 W2805935222.pdf 272 20 text 0.9996051 "Colnett’s observations are also interesting for his informants’ association of introduced diseases with the gods. Kamehameha’s consolidation of power was aided by natural hazards and introduced disease, which resulted in an unplanned demilitarisation of the islands. His attempted invasion of Kaua‘i in 1796 was thwarted when much of his fleet was capsized between O‘ahu and Kaua‘i. By 1804 Kamehameha was ready to attack" 2003 2432 W2805935222.pdf 272 21 separator 0.9607191 ¶ 2433 2435 W2805935222.pdf 272 22 bibliography 0.99755347 54 Sahlins (1989), p. 413; and Kahananui (1984), p. 173. 2435 2493 W2805935222.pdf 272 23 separator 0.7234087 ¶ 2493 2495 W2805935222.pdf 272 24 bibliography 0.99763227 55 King, in Beaglehole (1967), 3:1, pp. 560–61. 2495 2544 W2805935222.pdf 272 25 separator 0.68276733 ¶ 2544 2546 W2805935222.pdf 272 26 bibliography 0.9975215 56 Sahlins (1989), pp. 377–86, 389. 2546 2583 W2805935222.pdf 272 27 separator 0.7964661 ¶ 2583 2585 W2805935222.pdf 272 28 bibliography 0.9588743 57 Mariner, in Martin (1981), p. 280. 2585 2625 W2805935222.pdf 272 29 separator 0.5029518 ¶ 2625 2626 W2805935222.pdf 272 30 bibliography 0.99731255 58 Mariner, in Martin (1981), p. 280. 2626 2665 W2805935222.pdf 272 31 separator 0.7494943 ¶ 2665 2667 W2805935222.pdf 272 32 bibliography 0.99665165 59 Sahlins (1989), p. 379. 2667 2695 W2805935222.pdf 272 0 title 0.9621485 Cheetah-Human Conflict Elucidated by Stable Isotopes 0 52 W2066737901.pdf 7 1 separator 0.9717611 ¶ 52 54 W2066737901.pdf 7 2 paratext 0.9763481 PLOS ONE | www.plosone.org 8 August 2014 | Volume 9 | Issue 8 | e101917 54 126 W2066737901.pdf 7 0 title 0.7578209 13 H-I, 0 8 W4362539652.pdf 12 1 caption 0.7985662 Representative plots showing kinetic analyses of the activity of CDA (H) and AST (I) in plasma 8 104 W4362539652.pdf 12 2 separator 0.92047477 ¶ 105 107 W4362539652.pdf 12 3 caption 0.90541947 "collected from portal and hepatic veins. Three curves were shown for the normal and leukemic groups." 107 211 W4362539652.pdf 12 4 separator 0.9748519 ¶ 214 216 W4362539652.pdf 12 5 caption 0.986627 J, BM and Liver LSC percentage in leukemic mice shown in Fig. 6 J. 216 283 W4362539652.pdf 12 6 separator 0.94004977 ¶ 285 287 W4362539652.pdf 12 7 caption 0.5456869 Error bars denote mean ± 287 312 W4362539652.pdf 12 8 text 0.32536218 SD 312 315 W4362539652.pdf 12 9 caption 0.3692944 .*p 315 318 W4362539652.pdf 12 10 text 0.34523848 < 318 319 W4362539652.pdf 12 11 caption 0.4108269 0.05 , 319 325 W4362539652.pdf 12 12 text 0.37766808 ****p<0.00005 325 339 W4362539652.pdf 12 13 caption 0.3921375 339 340 W4362539652.pdf 12 14 text 0.3852534 . 340 341 W4362539652.pdf 12 15 separator 0.6814439 ¶ 342 348 W4362539652.pdf 12 16 math 0.40216336 "¶ ¶ ¶ ¶ ¶ ¶" 348 389 W4362539652.pdf 12 17 separator 0.3431678 391 392 W4362539652.pdf 12 18 math 0.3723034 ¶ 392 393 W4362539652.pdf 12 19 separator 0.4687763 395 396 W4362539652.pdf 12 20 math 0.31434587 ¶ 396 397 W4362539652.pdf 12 21 separator 0.81882954 "¶ ¶" 399 409 W4362539652.pdf 12 0 paratext 0.76009893 762 ROBINSON 0 13 W1979641548.pdf 0 1 title 0.80940723 : A SYNTHESIS OF TROPINONE. 13 40 W1979641548.pdf 0 2 separator 0.9928354 ¶ 41 43 W1979641548.pdf 0 3 title 0.9418848 T,SIII.---A Synthesis of Fropinone. 43 79 W1979641548.pdf 0 4 separator 0.9855149 ¶ 80 82 W1979641548.pdf 0 5 text 0.5857744 By ROBERT ROBINSON. 82 102 W1979641548.pdf 0 6 separator 0.9533454 ¶ 103 105 W1979641548.pdf 0 7 text 0.998627 "AMONG the noteworthy achievements of Willstatter in connexion with his investigation of the chemistry of tropine, there was nothing that contributed a greater share to the final solution of the problems encountered than the demonstration of the constitution of tropinone, a ketone first produced in 1896 (Will- statter, Ber., 1896, 29, 396; Ciamician and Silber, ?:bid., 490) by the oxidation of tropine, and later by a similar method from ecgonine (Willstatter, Bey., 1898, 3 1, 2655). This substance has become the central figure in the atropine group of the alkaloids, and, as shown below, may be regarded as the natural startiqg point in the Fynthetical preparation of a number of bases of great value in the practice of medicine and surgery." 105 885 W1979641548.pdf 0 8 separator 0.9394045 ¶ 886 888 W1979641548.pdf 0 9 paratext 0.93896484 Downloaded by University of Guelph on 02 September 2012 888 944 W1979641548.pdf 0 10 separator 0.6114627 ¶ 944 946 W1979641548.pdf 0 11 paratext 0.9717917 Published on 01 January 1917 on http://pubs.rsc.org | doi:10.1039/CT9171100762 946 1025 W1979641548.pdf 0 12 separator 0.9625859 ¶ 1025 1027 W1979641548.pdf 0 13 paratext 0.50276905 View 1027 1032 W1979641548.pdf 0 14 title 0.38992068 Online 1032 1039 W1979641548.pdf 0 15 separator 0.6519476 ¶ 1039 1041 W1979641548.pdf 0 16 paratext 0.4264102 / Journal 1042 1052 W1979641548.pdf 0 17 title 0.46082643 Homepage 1052 1061 W1979641548.pdf 0 18 separator 0.82757646 ¶ 1061 1063 W1979641548.pdf 0 19 paratext 0.48768944 / 1064 1066 W1979641548.pdf 0 20 title 0.49139896 Table of Contents for 1066 1088 W1979641548.pdf 0 21 paratext 0.4527698 this issue 1088 1099 W1979641548.pdf 0 0 paratext 0.97216797 "¶ JURNAL TUNAS PENDIDIKAN e ISSN -2621 -1629 Vol. 5. No. 1 (Oktober 202 2) http://ejournal.stkip -mmb.ac .id/index.php/pgsd/logi n ¶ 20" 1 405 W4312630982.pdf 12 1 separator 0.89518005 ¶ ¶ 406 412 W4312630982.pdf 12 2 text 0.9669978 "memiliki tanggung jawab terhadap kewajibannya sebagai mahasiswa. Sedangkan karakteristik mahasiswa AKN berkaitan dengan sikap bela negara adalah mengetahui kewajibannya sebagai warga negara serta memiliki moral yang baik, dan disertai keterampilan at au skills sesuai bidang keilmuannya pada masing - masing program studi yang ada di AKN Aceh Barat." 412 795 W4312630982.pdf 12 3 separator 0.9906465 ¶ ¶ 797 803 W4312630982.pdf 12 4 title 0.98155767 DAFTAR PUSTAKA 803 818 W4312630982.pdf 12 5 separator 0.98423886 ¶ 820 822 W4312630982.pdf 12 6 bibliography 0.9971605 "Ahmad, Kasman Hi dan Herman Oesman. (2000). Damai Yang terkoyak: Catatan Kelam dari Bumi Halmahera . Maluku Utara:Madani Press." 822 962 W4312630982.pdf 12 7 separator 0.64639664 ¶ ¶ 964 970 W4312630982.pdf 12 8 bibliography 0.9940297 "Bunyamin, Maftuh, . (2008). Internalisasi Nilai -Nilai Pancasila dan Nasionalisme Melalui Pendidikan Kewarganegaraan. Educationist Vol. II No. 2 Juli 2008." 970 1142 W4312630982.pdf 12 9 separator 0.74943316 ¶ 1144 1146 W4312630982.pdf 12 10 bibliography 0.5423469 1148 1149 W4312630982.pdf 12 11 separator 0.5390331 ¶ 1149 1150 W4312630982.pdf 12 12 bibliography 0.9978804 "Bourke, L., Bamber, P., dan Lyons, M. 2012. “ Global Citizens: Who Are They?”, dalam Education, Citizenship and Social Justice, 7 (2), hlm. 161 -174." 1150 1313 W4312630982.pdf 12 13 separator 0.7308545 ¶ 1314 1316 W4312630982.pdf 12 14 bibliography 0.9861178 "¶ Dudley, D. (2015). Civil –Military Relations in Bosnia and Herzegovina: State Legitimacy and Defense Institutions. Armed Forces & Society, 42(1), 119 –144." 1318 1489 W4312630982.pdf 12 15 separator 0.6870306 ¶ ¶ 1490 1496 W4312630982.pdf 12 16 bibliography 0.99762774 "Moleong, L. J. (2002). Metodo logi Penelitian Kualitatif . Bandung: PT Remaja Rosdakarya." 1496 1592 W4312630982.pdf 12 17 separator 0.60194016 ¶ ¶ 1594 1600 W4312630982.pdf 12 18 bibliography 0.9946923 "Mishael, Georgy dkk. (2016). Kebijakan Operasi Militer Tentara Nasional Indonesia Terhadap Organisasi Papua Merdeka dalam Perspektif Hukum Humaniter Internasional. Diponegoro Law Review, Jurnal Vol 5, No (2). 1 - 11." 1600 1837 W4312630982.pdf 12 19 separator 0.8750913 ¶ ¶ 1838 1844 W4312630982.pdf 12 20 bibliography 0.9962917 "Rahz, Muhammad Hidayat dkk. (1999). Menuju Masyarakat Terbuka: Lacak Jejak Pembaruan Sosial di Indonesia . Yogyakarta: Ashoka Indonesia." 1844 1993 W4312630982.pdf 12 21 separator 0.59667057 ¶ ¶ 1995 2001 W4312630982.pdf 12 22 bibliography 0.99220294 "Rahayu, N. S., & Yuniwati, I. (2019). Workshop Wawasan Kebangsaan dan Bela Negara Oleh Resimen Mahasiswa Sebagai Upaya Pencegahan Tindakan Radikalisme di Politeknik Negeri Banyuwangi . Seminar Nasional Hukum dan Kewarganegaraan, 64–68." 2001 2261 W4312630982.pdf 12 23 separator 0.80857855 ¶ ¶ 2262 2268 W4312630982.pdf 12 24 bibliography 0.9971689 "Subagyo, A. (2015). Bela Negara: peluang dan Tantangan di Era Globalisasi . Yogyakarta: Graha Ilmu." 2268 2377 W4312630982.pdf 12 25 separator 0.58039904 ¶ ¶ 2379 2385 W4312630982.pdf 12 26 bibliography 0.996295 "Setiono, K. Y. (2 017). Bela Negara Dalam Perspektif Strategi dan Kebijakan Pertahanan Negara . Wira media informasi:kementerian pertahanan." 2385 2541 W4312630982.pdf 12 27 separator 0.7064799 ¶ ¶ 2543 2549 W4312630982.pdf 12 28 bibliography 0.9838415 "Usman, H., & Akbar, P. S. (2009). Metodologi Penelitian Sosial . Jakarta: PT Bumi Aksara " 2549 2647 W4312630982.pdf 12 29 separator 0.76207 ¶ ¶ 2647 2652 W4312630982.pdf 12 30 bibliography 0.99582475 "Ulfah, R. A., Prasetyo, D., & Marzuki. (2018 ). Pengaruh Model PBM dalam Pembelajaran PPKn terhadap Kemampuan Berpikir Kritis dan Sikap Demokratis. Jurnal Citizenship , 6(2), 125 –139." 2652 2852 W4312630982.pdf 12 31 separator 0.79452956 ¶ 2853 2855 W4312630982.pdf 12 32 bibliography 0.5768518 2857 2858 W4312630982.pdf 12 33 separator 0.57409644 ¶ 2858 2859 W4312630982.pdf 12 34 bibliography 0.9976032 "Widodo, S. (2011). Implementasi Bela Negara Untuk Mewujudkan Nasionalisme. Jurnal CIVICS , I(1), 18 –31" 2859 2972 W4312630982.pdf 12 35 separator 0.9932124 ¶ 2973 2975 W4312630982.pdf 12 0 paratext 0.52374446 A/Chicken/Hub 0 13 W4200476889.pdf 27 1 title 0.4535895 e 13 14 W4200476889.pdf 27 2 paratext 0.5884429 i/147/2018 T . .G . .G. . E E . S . ........T. 14 60 W4200476889.pdf 27 3 table 0.8821224 "0 ... ...CSK ...GS C A/Chicken/Hubei/149/2018 . D T G R .GE T . . D . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Hubei/251/2018 . D T G R .GD . . . E . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C54/2018 . D T G R ..D . . . E . R G.......T. 0 ... ...CSK ...GS C A/Chicken/Hubei/95/2018 T . . . . ... . E E . S . ....... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C82/2018 . D T G R .GD . . . E . R G.......T. 0 ... ...CSK ...GS C A/Chicken/Hubei/261/2018 . D T G R .GD . . . E . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Hubei/80/2018 T . . . . ... . E E . S . ........T. 0 ... ...CSK ...GS C A/Chicken/Hubei/160/2018 . D T G R .GE T . . D . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C107/2018 . D T G R .GD . . . E . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C169/2018 . D T G R .GD . . . E . R G...... .. 0 ... ...CSK ...GS C A/Chicken/Jiangxi/C15/2018 . D T N R DGN T . . D . R ....... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C79/2018 . D T G R .GD . . . E . R G...... .. 0 ... ...CSK ...GS C A/Environment/Jiangxi/E15/2018 . D T N R DGN T . . D . R ....... .. 0 ... ...CSK ...GS C A/Chicken/Jiangxi/C19/2018 . D T N R DGN T . . D . R ....... .. 0 ... ...CSK ...GS C A/Chicken/Shandong/C80/2018 . D T G R .GD . . . E . R G ...... .. 0 ... ...CSK ...GS C A/Chicken/Jiangxi/C16/2018 . D T N . DGN T . . D . R ....... .. 0 ... ...CSK ...GS C A/Chicken/Hubei/146/2018 T . . . . ... . E E . S . ........T. 0 ... ...CSK ...GS C A/Chicken/Hubei/78/2018 T . . . . ... . E E . S . ........T. 0 ... ...CSK ...GS" 60 1675 W4200476889.pdf 27 4 separator 0.69750994 ¶ C ¶ 1675 1681 W4200476889.pdf 27 5 paratext 0.98103493 PeerJ reviewing PDF | (2020:07:50819:2:0:NEW 2 Sep 2021) 1681 1738 W4200476889.pdf 27 6 separator 0.9904636 ¶ 1738 1740 W4200476889.pdf 27 7 paratext 0.51104534 Manuscripttobereviewed 1740 1763 W4200476889.pdf 27 0 title 0.9718992 "The effect of negativ e temperatures on the retaining walls of deep pits" 0 75 W4322708196.pdf 0 1 separator 0.98942876 ¶ 76 78 W4322708196.pdf 0 2 contact 0.84482163 "Sergey Metelkin1*, Vladimir Paramonov1 Emperor Alexander I St. Petersburg State Transport University, 190031 Saint Petersburg, Russia" 78 215 W4322708196.pdf 0 3 separator 0.9961215 ¶ 217 219 W4322708196.pdf 0 4 text 0.9989371 "Abstract . In countries with negative winter temperatures, pits and walls of underground structures are subjected to additional forces caused by frost heaving forces. In Russian construction practice, cases of the impact of such forces on the struts and anchors of construction walls are known, which led to the loss of stability of the struts and the failure of the anchors. Obviously, the design of retaining walls in winter should take into account the effect of additional forces caused by frost heaving and their evolution over time. The solution of test problems for an open pit shows that under certain conditions, the forces in the struts can exceed their values by an order of magnitude, determined when taking into account only the active pressure of the soil. Experimental studies were carried out to assess the processes of development of forces in the elements of the retaining walls in winter. The calculated assessment of the temperature fields and the stress-strain state in the excavation walls was performed using the Termoground program. The comparison of results of experimental and calculated data are shown in the article. The comparison of results of experimental and calculated data is shown in the article." 219 1475 W4322708196.pdf 0 5 separator 0.9968513 ¶ 1476 1478 W4322708196.pdf 0 6 title 0.9833171 1 Introduction 1478 1493 W4322708196.pdf 0 7 separator 0.9964404 ¶ 1494 1496 W4322708196.pdf 0 8 text 0.9996018 "At present, in conditions of dense urban development, the construction of underground structures is increasingly being carried out to accommodate parking lots, shopping malls, pedestrian crossings, road junctions, etc. In many cities of the world, this task is successfully implemented due to appropriate geotechnical conditions. A number of cities, including St. Petersburg, belong to regions with difficult conditions for the construction of underground structures, such as thixotropic fluid soils, a large number of faults in the underlying strata, as well as the proximity of groundwater to the surface, the presence of natural reservoirs within the city (rivers, canals), congestion of underground utilities and other adverse factors [1-4] ." 1496 2261 W4322708196.pdf 0 9 separator 0.572097 2262 2263 W4322708196.pdf 0 10 text 0.98740405 "¶ Also, the engineering-geological conditions of St. Petersburg are characterized by the presence of a thick layer (15 - 20 m) of weak clayey soils of fluid or fluid -plastic consistency. With low strength, these soils have a relatively high density, which provides high pressure on the walls of underground structures. Under favorable geotechnical conditions such as high mechanical characteristics of soils, low groundwater levels, the absence of buildings and structures in the risk zone, the " 2263 2775 W4322708196.pdf 0 11 separator 0.8390104 ¶ ¶ 2775 2827 W4322708196.pdf 0 12 contact 0.99121654 * Corresponding author: s.metelkin@bk.ru 2827 2868 W4322708196.pdf 0 13 paratext 0.97315925 "1E3S Web of Conferences 371, 02006 (2023) https://doi.org/10.1051/e3sconf/202337102006 AFE-2022 © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (http://creativecommons.org/licenses/by/4.0/)." 2869 3171 W4322708196.pdf 0 0 title 0.941844 "Whole-Genome Sequence of Paenibacillus marchantiae Isolated from the Liverwort Marchantia polymorpha subsp. ruderalis" 0 119 W4381598707.pdf 0 1 separator 0.4495945 119 120 W4381598707.pdf 0 2 title 0.83031285 ¶ Ecotype BoGa 120 134 W4381598707.pdf 0 3 separator 0.9725059 ¶ 134 136 W4381598707.pdf 0 4 contact 0.9429499 "Anja Meierhenrich ,a,b Bianca Frommer ,a,b Wiebke Halpape ,a,b Marvin Hildebrandt ,aIsabell E. Bleile ,c Judith Helmig ,d Sabine Zachgo ,d Andrea Bräutigam ,a,b Bart Verwaaijena,b,e" 136 332 W4381598707.pdf 0 5 separator 0.8190775 ¶ 332 334 W4381598707.pdf 0 6 contact 0.99010116 "aComputational Biology, Faculty of Biology, Bielefeld University, Bielefeld, Germany bComputational Biology, Centre of Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany cMolecular Biotechnology, Bielefeld University, Bielefeld, Germany dBotany, School of Biology and Chemistry, Osnabrück University, Osnabrück, Germany eDepartment of Genetics, Martin-Luther-University-Halle-Wittenberg, Halle (Saale), Germany" 334 768 W4381598707.pdf 0 7 separator 0.9912378 ¶ 768 770 W4381598707.pdf 0 8 title 0.7784724 ABSTRACT 770 779 W4381598707.pdf 0 9 text 0.993161 "The bacterium Paenibacillus marchantiae was isolated from male plants of the liverwort Marchantia polymorpha subsp. ruderalis ecotype BoGa. Here, we report on the complete genome sequence generated from long Nanopore reads. The genome sequence comprises 6,983,959 bp with a GC content of 46.02% and 6,195 predicted protein- coding genes." 779 1125 W4381598707.pdf 0 10 separator 0.92232937 ¶ 1125 1127 W4381598707.pdf 0 11 text 0.9945849 "Species belonging to the genus Paenibacillus are rod-shaped and Gram-positive, Gram- variable, or Gram-negative bacteria with an aerobic or facultative anaerobic lifestyle (1, 2). Until today, 285 species are known (3). Back in 1993, the genus was formed from a subgroup of bacilli using 16S rRNA (2). Representatives of Paenibacillus have been found in various places, such as in animals (4), rhizospheres (5), leaves (6), and soil (7). Some are known to sup-port plant growth, for example by nitrogen fixation (8), enabling iron uptake by siderophores (9) or through their antimicrobial resistance (10)." 1127 1742 W4381598707.pdf 0 12 separator 0.93240577 ¶ 1742 1744 W4381598707.pdf 0 13 text 0.9989935 "Male Marchantia polymorpha subsp. ruderalis ecotype BoGa plants (11) were grown in petri dishes on half-strength Gamborg ’s medium (Gamborg B5; Duchefa Biochemie B.V., Netherlands) at room temperature under 16-h/8-h day-night conditions. The cetyltrimethylam-monium bromide (CTAB) method was applied for DNA extraction using whole plants (12)." 1744 2092 W4381598707.pdf 0 14 separator 0.8533819 ¶ 2092 2094 W4381598707.pdf 0 15 text 0.99756056 "DNA quality was checked with the Invitrogen Qubit 4 fluorometer (Thermo Fisher Scienti fic Inc., USA). To prepare DNA for sequencing, the short read eliminator kit (PacBio, USA) andthe ligation sequencing genomic DNA (gDNA) kit (SQK-LSK109-XL; Oxford NanoporeTechnologies [ONT], Oxford, UK) were used. For sequencing, one R9.4.1 and one R10.0 flow cell were run on a GridION platform, and base calling was performed with the high-accuracy model (MinKNOW v1.4.3; all from ONT). All programs were run with default parameters unless otherwise speci fied. Genomic reads were checked for contaminations with BLASTN searches (13) against the NCBI nucleotide collection database, and reads matching Paenibacillus genome assemblies were filtered (NCBI; Organism “Paenibacillus ”;D a t a b a s e “Assembly ”;B L A S T 2.8.11;Ev a l u e ,0.001) ( https://www.ncbi.nlm.nih.gov/assembly ).Paenibacillus marchantiae genome assembly was performed with Canu (v2.2) (14 ) assuming a genome size of 7.0 Mbp. Racon (v1.4.20) (15), Minimap2 (v2.22-r1101; parameter “–ax map-ont ”) (16), and Medaka (v1.4.3; parameter “-m r941_min_high_g360 ”; ONT) were used for polishing, and Berokka (v0.2.3) ( https://github.com/tseemann/berokka ) was run for overlap trimming. The assembly resulted in one circular contig (6,983,959 bp; GC content of 46.02%) (Table 1 )." 2094 3454 W4381598707.pdf 0 16 separator 0.9848955 ¶ 3454 3456 W4381598707.pdf 0 17 text 0.94889617 "Benchmarking Universal Single-Copy Orthologs (BUSCO) (v5.4.3; database “bacillales_odb10 ”) (17) and CheckM (v1.2.2) (18) were applied to check assembly quality resulting in 0.097%contamination and 99.84% assembly completeness. A total of 6,195 protein-coding genes" 3456 3724 W4381598707.pdf 0 18 paratext 0.63308895 Editor Simon 3724 3736 W4381598707.pdf 0 19 contact 0.43207455 Roux 3736 3741 W4381598707.pdf 0 20 paratext 0.5548944 ", DOE Joint Genome Institute" 3741 3771 W4381598707.pdf 0 21 separator 0.6061638 3771 3772 W4381598707.pdf 0 22 paratext 0.96283734 "¶ Copyright © 2023 Meierhenrich et al. This is an open-access article distributed under the termsof the Creative Commons Attribution 4.0 International license ." 3772 3936 W4381598707.pdf 0 23 separator 0.93937075 ¶ 3936 3938 W4381598707.pdf 0 24 contact 0.9922164 "Address correspondence to Anja Meierhenrich, anja.meierhenrich@uni-bielefeld.de." 3938 4021 W4381598707.pdf 0 25 separator 0.35207608 4021 4022 W4381598707.pdf 0 26 contact 0.36161104 ¶ 4022 4023 W4381598707.pdf 0 27 paratext 0.78368384 The authors declare no con flict of interest. 4023 4068 W4381598707.pdf 0 28 separator 0.93180895 ¶ 4068 4070 W4381598707.pdf 0 29 paratext 0.95247424 "Received 10 May 2023 Accepted 9 June 2023 Month YYYY Volume XX Issue XX 10.1128/mra.00354-23 1GENOME SEQUENCES Downloaded from https://journals.asm.org/journal/mra on 27 June 2023 by 129.70.43.49." 4070 4273 W4381598707.pdf 0 30 separator 0.99557734 ¶ 4273 4275 W4381598707.pdf 0 0 paratext 0.96087146 "274 VÉRTICES, Campos dos Goytacazes/ RJ, v.14, n. Especial 1, p. 271-278, 2012Maria Inês Albernaz Kuryde" 0 111 W2576239192.pdf 3 1 title 0.6863307 mudanças nos projetos educacionais, referentes à formação 111 169 W2576239192.pdf 3 2 separator 0.82410073 ¶ 170 172 W2576239192.pdf 3 3 text 0.98188025 de trabalhadores que atendam a este novo panorama mundial, relacionado ao processo de globalização. 172 272 W2576239192.pdf 3 4 separator 0.6292182 ¶ 272 274 W2576239192.pdf 3 5 text 0.9991237 "Dessa forma, são muito importantes os benefícios gerados pelo intercâmbio de alunos, professores e técnicos administrativos com instituições parceiras de outros países. Além disso, os projetos de cooperação internacional permitem um conhecimento mútuo em pesquisas, o desenvolvimento de tecnologias, sistemas de ensino e formação pedagógica, além de gerar visibilidade internacional às ações dos Institutos Federais brasileiros." 274 706 W2576239192.pdf 3 6 separator 0.9685112 ¶ 706 708 W2576239192.pdf 3 7 text 0.99900293 "Diante desse quadro, espera-se construir uma unidade em torno das ações estratégicas de Relações Internacionais dos Institutos Federais, otimizando todo o potencial que existe no relacionamento da Rede Federal de Educação Profissional e Tecnológica com as Instituições de outros países. No caso das dimensões continentais brasileiras, as Relações Internacionais representam um estímulo para compreender como a proximidade espacial convive com grandes diferenças relativas à formação histórica e à composição sócio-cultural dos diferentes países e sub-regiões da América do Sul. Para isso, é fundamental que sejam criados laços fronteiriços com os diversos países da região." 708 1387 W2576239192.pdf 3 8 separator 0.98160917 ¶ 1387 1389 W2576239192.pdf 3 9 text 0.98820347 "No que tange à Educação Profissional e Tecnológica, é papel dos Institutos Federais promover a integração regional, desenvolvendo políticas específicas de cooperação e intercâmbio. Assim, compreende-se que as Relações Internacionais representam instrumento fundamental para a melhoria da Educação, que se constitui elemento imprescindível para o desenvolvimento econômico e social do país." 1389 1787 W2576239192.pdf 3 10 separator 0.88064384 ¶ 1787 1789 W2576239192.pdf 3 11 text 0.9987257 "(...)Os Institutos Federais devem desenvolver a cooperação científica e tecnológica no sentido de ampliar a qualidade da pesquisa. O desenvolvimento da ciência e da tecnologia sempre ocorreu no âmbito da cooperação internacional. É imprescindível que se atue de forma conjunta, a fim de efetuar contribuições para o progresso da ciência e da tecnologia." 1789 2146 W2576239192.pdf 3 12 separator 0.9124676 ¶ 2147 2149 W2576239192.pdf 3 13 text 0.99891895 "Portanto, é necessário incentivar o trabalho de grupos de pesquisa em redes internacionais, especialmente, considerando a indissociabilidade do ensino, da pesquisa e da extensão. Este desenvolvimento terá repercussão, também, na qualidade do ensino profissional e tecnológico, e na capacitação dos professores e dos técnicos administrativos." 2149 2496 W2576239192.pdf 3 0 paratext 0.8092163 Caveião et al. Quality of 0 28 W4311031100.pdf 2 1 title 0.5790609 floral stems of different gladiolus cultivar 28 72 W4311031100.pdf 2 2 paratext 0.700766 "s grown in a subtropical environment 23" 72 115 W4311031100.pdf 2 3 separator 0.7876966 ¶ 116 118 W4311031100.pdf 2 4 paratext 0.4366724 programming language. 119 141 W4311031100.pdf 2 5 text 0.43239567 In the case 141 153 W4311031100.pdf 2 6 paratext 0.42051554 of 153 156 W4311031100.pdf 2 7 text 0.40780148 qual 156 161 W4311031100.pdf 2 8 paratext 0.44747147 itative 161 168 W4311031100.pdf 2 9 text 0.4828772 ¶ 169 171 W4311031100.pdf 2 10 paratext 0.45447487 classification 171 186 W4311031100.pdf 2 11 text 0.5041279 , 186 187 W4311031100.pdf 2 12 paratext 0.42230564 descriptive 187 199 W4311031100.pdf 2 13 text 0.43385944 statistics were performed. 199 226 W4311031100.pdf 2 14 separator 0.98402077 ¶ ¶ 228 234 W4311031100.pdf 2 15 title 0.9877594 Results and discussion 234 257 W4311031100.pdf 2 16 separator 0.9940425 ¶ 259 261 W4311031100.pdf 2 17 text 0.99967104 "Stem length was influenced by the different gladiolus cultivars studied (P=0.0048) (Table 1). The highest values were found for the cultivars White Friendship and Jester, with an average of 1.07 m. In the case of pendulum length was also affected by the different cultivars of gladiolus cultivated (P=0.0152) (Table 1). The highest value observed occurred for the cultivar White Friendship. On the other hand, the lowest value was observed for the cultivar Red Beauty." 262 756 W4311031100.pdf 2 18 separator 0.9100588 "¶ ¶" 758 768 W4311031100.pdf 2 19 title 0.8591928 "Table 1. Total stem length, pendant length, stem diameter , and number of florets per spike as a function of different gladiolus cultivars" 768 910 W4311031100.pdf 2 20 separator 0.9604773 ¶ 912 914 W4311031100.pdf 2 21 table 0.9940422 "Cultivar Total stem length (m) Stem length (m) Stem diameter (cm) Number of florets per spike Jester 1,07a 0,47ab 1,13a 16,47a Red Beauty 0,92b 0,43b 1,03b 13,83b White Friendship 1,08a 0,52a 1,14a 16,1" 914 1148 W4311031100.pdf 2 22 separator 0.94730484 ¶ 1149 1151 W4311031100.pdf 2 23 text 0.75371826 Averages followed by the same letters in the column do not differ by the LSD test at 5% probability of error. 1151 1261 W4311031100.pdf 2 24 separator 0.8689544 "¶ ¶" 1263 1273 W4311031100.pdf 2 25 text 0.99958324 "In the case of the commercial classification of the stems according to length (Figure 2) , there was a great difference among the cultivars evaluated. For Jester and White Friendship approximately 90% of the stems were in the 90 or 110 class. In the case of Red Beauty, a large percentage of the stems were in the 75 and 90 classes." 1274 1625 W4311031100.pdf 2 26 separator 0.8695766 "¶ ¶ ¶" 1627 1645 W4311031100.pdf 2 27 caption 0.9956984 Figure 2. Commercial classification of the cultivars White Friendship, Red Beauty and Jester according to stem length. 1645 1764 W4311031100.pdf 2 28 separator 0.97920734 ¶ ¶ 1766 1772 W4311031100.pdf 2 29 text 0.9996089 "The quality of gladiolus stems is highly related to the total length of the stem. According to Veiling Holambra (2013) for the minimum standard for commercialization, gladiolus stems need to present a ratio between stem length:stem length greater than 0.4. In this case, most of the stems presented a standard for commercialization, and all evaluated stems, 89.5% of the Jester cultivar, 97.4% of Red Beauty , and 97.4% of White Friendship were within the standard. In this case, this standard guarantees a produc t with a harmonic proportion between the portion without flowers and the stem, which makes it aesthetically pleasing (Schwab et al., 2015)." 1773 2467 W4311031100.pdf 2 30 separator 0.98099893 ¶ 2469 2471 W4311031100.pdf 2 31 text 0.9996713 "The differences found in the values of the total length of the stem and of the pendulum may express the responses to climatic factors during the experiment, especially the average temperatures between 8 oC and 25 oC that occurred during the vegetative phase. The cultivars White Friendship and Jester developed their stalk during the hottest days of the experimental perio d, between April 26, 2020 and May 08, 2020. On the other hand, the cultivar Red Beauty faced lower temperatures (Figure 1). This factor is related to the cycle of each of the cultivars (early and intermediate II). According to Uhlmann et al. (2017) , the op timal temperature for development in the vegetative phase is 27oC, and temperatures below 15oC are harmful in this phase of development (Severino, 2007)." 2471 3299 W4311031100.pdf 2 32 separator 0.97258776 ¶ 3301 3303 W4311031100.pdf 2 33 text 0.9209198 "Pereira (2014) in his work found average values of gladiolus stem length for the White 0 10 20 30 40" 3303 3407 W4311031100.pdf 2 34 table 0.64709324 "50 60 70 75 90 110 Stem percentage (%)" 3407 3449 W4311031100.pdf 2 35 separator 0.9403386 ¶ 3451 3453 W4311031100.pdf 2 36 table 0.8024796 "Commercial grade - Stem length White Friendship Red Beauty Jester" 3453 3525 W4311031100.pdf 2 0 paratext 0.88393384 17364 0 5 W4308844551.pdf 16 1 bibliography 0.99414444 "8. Bashorun A, Nguku P, Kawu I, Ngige E, Ogundiran A, Sabitu K, et al. A 365 description of HIV prevalence trends in Nigeria from 2001 to 2010: what is the 366 progress, where is the problem? Pan Afr Med J. 2014;18 Suppl 1:3." 5 237 W4308844551.pdf 16 2 separator 0.9611392 ¶ 238 240 W4308844551.pdf 16 3 bibliography 0.99530375 "367 9. Ghebre RG, Grover S, Xu MJ, Chuang LT, Simonds H. Cervical cancer control in 368 HIV-infected women: Past, present and future. Gynecol Oncol Rep. 2017 369 Aug;21:101–8." 240 422 W4308844551.pdf 16 4 separator 0.97919995 ¶ 423 425 W4308844551.pdf 16 5 bibliography 0.995246 370 10. Moon TD, Silva-Matos C, Cordoso A, Baptista AJ, Sidat M, Vermund SH. 425 502 W4308844551.pdf 16 6 separator 0.71407086 ¶ 503 505 W4308844551.pdf 16 7 bibliography 0.97885215 "371 Implementation of cervical cancer screening using visual inspection with acetic 372 acid in rural Mozambique: successes and challenges using HIV care and 373 treatment programme investments in Zambé zia Province. 2012; Available from: 374 http://dx.doi.org/10.7448/IAS.15.2.17406" 505 798 W4308844551.pdf 16 8 separator 0.9729493 ¶ 798 800 W4308844551.pdf 16 9 bibliography 0.99532205 "375 11. WHO. Global strategy to accelerate the elimination of cervical cancer as a public 376 health problem [Internet]. 2020. Available from: http://apps.who.int/bookorders." 800 978 W4308844551.pdf 16 10 separator 0.8953589 ¶ 978 980 W4308844551.pdf 16 11 bibliography 0.9906963 "377 12. World Health Organisation. Costing the National Strategic Plan on Prevention and 378 Control of Cervical Cancer: Nigeria, 2017–2021. 2020;" 980 1130 W4308844551.pdf 16 12 separator 0.8634665 ¶ 1131 1133 W4308844551.pdf 16 13 bibliography 0.97875285 "379 13. Chung MH, Mckenzie KP, de Vuyst H, Richardson BA, Rana F, Pamnani R, et al. 380 Comparing Papanicolau smear, visual inspection with acetic acid and human 381 papillomavirus cervical cancer screening methods among HIV-positive women by 382 immune status and antiretroviral therapy. 2013;" 1133 1437 W4308844551.pdf 16 14 separator 0.83998764 ¶ 1438 1440 W4308844551.pdf 16 15 bibliography 0.98053116 383 14. Okunade KS, Adejimi AA, John-Olabode SO, Oshodi YA, Oluwole AA. An 1440 1517 W4308844551.pdf 16 16 separator 0.5764168 ¶ 1517 1518 W4308844551.pdf 16 17 bibliography 0.93145347 384 Overview of HPV Screening Tests to Improve Access to Cervical Cancer 1518 1591 W4308844551.pdf 16 18 separator 0.9164842 ¶ 1592 1594 W4308844551.pdf 16 19 bibliography 0.94295436 385 Screening Amongst Underserved Populations: From Development to 1594 1661 W4308844551.pdf 16 20 separator 0.95160097 ¶ 1662 1664 W4308844551.pdf 16 21 bibliography 0.95104074 386 Implementation. Risk Manag Healthc Policy [Internet]. 2022 Sep;Volume . CC-BY 1664 1747 W4308844551.pdf 16 22 paratext 0.9418063 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review)preprint The copyright holder for this this version posted November 11, 2022. ; https://doi.org/10.1101/2022.11.10.22282170doi: medRxiv preprint 1747 2083 W4308844551.pdf 16 0 paratext 0.97659725 Tânia M. B. Santos & Jorge de Lucas Júnior 0 42 W1967232428.pdf 11 1 separator 0.8273647 ¶ 43 45 W1967232428.pdf 11 2 paratext 0.9544068 Eng. Agríc., Jaboticabal, v.24, n.1, p.25-36, jan./abr. 2004 36 45 109 W1967232428.pdf 11 3 separator 0.9896298 ¶ 110 112 W1967232428.pdf 11 4 bibliography 0.99796015 PIMENTEL, D. Handbook of energy utilization in agriculture. Boca Raton: CRC Press, 1980. 475 p. 112 208 W1967232428.pdf 11 5 separator 0.96133465 ¶ 209 211 W1967232428.pdf 11 6 bibliography 0.99809605 "QUESADA, G.M.; BEBER, J.A.C.; SOUZA, S.P. Balanços energéticos agropecuários: uma proposta metodológica para o Rio Grande do Sul. 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Genome Res. 1999;9:677-9. https://www.ncbi.nlm.nih.gov/projects/SNP/. Accessed 13 May, 2018." 704 931 W4247351045.pdf 10 8 separator 0.9785975 ¶ 931 933 W4247351045.pdf 10 9 bibliography 0.9979991 "44. Adzhubei IA, Schmidt S, Peshkin L, Ramensky VE, Gerasimova A, Bork P, et al. A method and server for predicting damaging missense mutations. Nat Methods 2010;7:248-9. http://genetics.bwh.harvard.edu/pph2/. Accessed 13 May, 2018." 933 1168 W4247351045.pdf 10 10 separator 0.9726566 ¶ 1168 1170 W4247351045.pdf 10 11 bibliography 0.99779385 "45. Kumar P, Henikoff S, Ng PC. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc. 2009;4:1073-81. http://sift.jcvi.org/www/SIFT_enst_submit.html. Accessed 13 May, 2018." 1170 1406 W4247351045.pdf 10 12 separator 0.9903251 ¶ 1406 1408 W4247351045.pdf 10 13 paratext 0.47832182 4 1408 1410 W4247351045.pdf 10 0 paratext 0.61303306 o\THEPHYSICIAN'S Z 0 18 W4235983626.pdf 0 1 separator 0.91465735 ¶ 18 20 W4235983626.pdf 0 2 paratext 0.4921539 POT 20 24 W4235983626.pdf 0 3 title 0.6542866 ASSIUM 24 30 W4235983626.pdf 0 4 paratext 0.7317845 30 31 W4235983626.pdf 0 5 title 0.52811813 METABOLISM 31 41 W4235983626.pdf 0 6 paratext 0.51633656 IN 41 44 W4235983626.pdf 0 7 title 0.49798387 HEALTH 44 50 W4235983626.pdf 0 8 paratext 0.53721356 AND 50 54 W4235983626.pdf 0 9 title 0.5070004 DIS 54 57 W4235983626.pdf 0 10 paratext 0.5686544 "- EASE. " 57 67 W4235983626.pdf 0 11 contact 0.5923912 "Howard L.Holley, M.D.,Department ofMedicine, University ofAlabama; andWarner W.Carlson, Ph.D.," 67 163 W4235983626.pdf 0 12 paratext 0.34794003 ¶ 163 165 W4235983626.pdf 0 13 contact 0.52590925 Department ofBiochemistry, University ofAlabama 165 213 W4235983626.pdf 0 14 bibliography 0.37516984 . 213 214 W4235983626.pdf 0 15 contact 0.4508757 Grune 214 219 W4235983626.pdf 0 16 bibliography 0.3955904 and 219 223 W4235983626.pdf 0 17 paratext 0.33379236 S 223 224 W4235983626.pdf 0 18 contact 0.3450417 tratton 224 231 W4235983626.pdf 0 19 bibliography 0.41390648 , 231 232 W4235983626.pdf 0 20 paratext 0.38796693 NewYork 232 240 W4235983626.pdf 0 21 bibliography 0.45930216 , 240 241 W4235983626.pdf 0 22 paratext 0.6928948 1955.131pages,$4.50. 241 261 W4235983626.pdf 0 23 separator 0.9951452 ¶ 261 263 W4235983626.pdf 0 24 text 0.9995269 "Although thereislittlethatisnewinthismonograph, the normalcontrolofpotassium metabolism, andthefactorsin diseasewhichmayalterbodypotassium levelsarepresented moderately well.Incertainareastheauthorsdonotappear tohavehadbroadgrassroots'experience withcertaintypes ofpotassium andelectrolyte problems. Inaddition, therole ofpotassium inenzymatic activities relatedtoglucoseand proteinmetabolism, andtheinterrelationships ofpotassium withotherions,arestressed. Clinicalsymptomatology and findings, pluselectrocardiographic changesofhighandlow serumpotassium levels,and/ordecreased totalbodypotas- siumarepresented well.Theweakest partofthemono- graphisthesectionontreatment ofpotassium deficitswhich showslackofextensive experience inthecorrection ofsuch deficits,particularly bytheparenteral intravenous route." 263 1100 W4235983626.pdf 0 25 separator 0.93034446 ¶ *** ¶ 1100 1108 W4235983626.pdf 0 26 title 0.78955483 PUBLIC RELATIONS INMEDICAL PRACTICE 1108 1144 W4235983626.pdf 0 27 bibliography 0.4501765 . 1144 1145 W4235983626.pdf 0 28 contact 0.73424613 "James E.Bryan, Administrator, Medical-Surgical PlanofNew Jersey; Formerly Executive Officer, theMedical SocietyofNewJersey, Chairman" 1145 1282 W4235983626.pdf 0 29 bibliography 0.5880849 ofthe 1282 1288 W4235983626.pdf 0 30 contact 0.5304612 Medical 1288 1295 W4235983626.pdf 0 31 bibliography 0.5092989 Society 1295 1304 W4235983626.pdf 0 32 contact 0.47950366 Exec 1304 1308 W4235983626.pdf 0 33 bibliography 0.7593729 "u- " 1308 1313 W4235983626.pdf 0 34 contact 0.52281547 tivesConference 1313 1328 W4235983626.pdf 0 35 bibliography 0.74571985 ". TheWilliams &Wilkins Company, Bal- timore, 1955.301pages,$5.00." 1328 1395 W4235983626.pdf 0 36 separator 0.9958928 ¶ 1395 1397 W4235983626.pdf 0 37 text 0.99946874 "Sincethethirdgeneration ofAdamandEve'soffspring, homosapienshasbeenblestorbesetwithrelations. Inthe oldendaystheywerereferred toasrichorpoor,butinthe twentieth century alargenumber aremadeupofthat peculiar entityknownas""public."" Publicrelations carries ahostofdefinitions, thesimplest onebeing""reputation.""Reputation maybebuiltorpurchased, theformerenduring andthelatterevanescent. ""Thetraditional ethicsofthe profession, itsancientidealofservice,itsnoblecodeof conduct-these aretheimmutable foundations uponwhich anypublicrelations program mustbebased.""Theauthor usesthesewordsinhisintroduction andreferstothem manytimesinthesucceeding chapters." 1397 2066 W4235983626.pdf 0 38 separator 0.9912571 ¶ 2066 2068 W4235983626.pdf 0 39 text 0.98874885 "Thepersonalrelationship ofdoctorandpatient,thefinan- cialrelationship, theethical,socialandinstitutional rela- tionships ofthephysician withhiscolleagues aredealtwith. Therelationship ofphysicians withprepaidmedical care plansandfinallytherelationships ofthephysician with himselfaredealtwith." 2068 2372 W4235983626.pdf 0 40 separator 0.96592236 ¶ 2372 2374 W4235983626.pdf 0 41 text 0.99941176 "Thereading isnotlight,butthereisnodoubtthatthis bookconstitutes amineofusefulinformation fortheyoung physician. TheauthorisAdministrator oftheBlueShield PlaninNewJerseyandwasformerly theExecutive Secre- taryoftheMedicalSocietyofWestchester Countyformany years.Hewriteswithclarityandsincerity. Afrankdiscus- sionofcorporate practice ofmedicine whichappears in chapter ninewillbeofparticular interesttoallphysicians inCalifornia, notablythoseonthefulltimestaffsofnon- profitprivatehospitals.""Thetendency ofcertainhospitals toengagefulltime salariedphysicians andsurgeons incommunities wherethe profession hasadequate personnel toprovideequallycom- petentstaffonavisitingbasisclearlyinterferes withthe normalopportunities ofphysicians toachieveleadership and recognition according totheirprofessional abilities...The physician, likeanyotherman,cannotservetwomasters. If heisanemployee ofthehospital, hemustfirstdothebid- dingofthehospital, andthenheisnolongerprimarily the servantofthepatient.Itseemstomethatsuchpractices are badforthepatientinthelongrun.""" 2374 3466 W4235983626.pdf 0 42 separator 0.87375283 ¶ 3466 3468 W4235983626.pdf 0 43 text 0.9983986 "Theauthorfurtherstates,""Idonotseehowanyonecould seriously arguethatitwouldbenefitthepeopleifthecon- trolofmedical practice weretopassoutofthehandsof medicalpractitioners andintothehandsofhospitals. Yet, thatistheinevitable resultofsuchatendency asweare nowwitnessing insomelargemedical centers...The responsibility oftheindividual physician totheindividual patientisdirect,unassignable, inescapable andindivisible. Itissupported andenforced bylawandbyuniversal public opinion.""***" 3468 3967 W4235983626.pdf 0 44 separator 0.9957516 ¶ 3967 3969 W4235983626.pdf 0 45 paratext 0.61508447 TEXTBOOK OFCHIROPODY-Second 3969 3997 W4235983626.pdf 0 46 bibliography 0.8523782 "Edition. Mar- garetJ.McKenzie Swanson, B.Litt., F.Ch.S., Co-Founder ofEdinburgh FootClinic andSchool ofChiropody. The Williams andWilkins Company, Baltimore, 1954.268 pages, $5.00" 3997 4185 W4235983626.pdf 0 47 paratext 0.5142483 . 4185 4186 W4235983626.pdf 0 48 separator 0.995378 ¶ 4186 4188 W4235983626.pdf 0 49 text 0.9993191 "Thisbookis,asthetitlestates,primarily atextbook of chiropody forstudents ofchiropody. Inthatsenseitisquite complete andwellillustrated. Theauthormakesnoattempt tocoverthemedicalaspectsoffootdisease.Minorlesions whichcanbetreatedbythechiropodist arewelldescribed aswellasorthodox methods appliedbychiropody tocor- recttheselesions.Thetreatment ofclubfeetisnotdis- cussednorarethevarioussurgical procedures available forcorrecting footdisability considered." 4188 4660 W4235983626.pdf 0 50 separator 0.8398978 ¶ *** ¶ 4660 4668 W4235983626.pdf 0 51 bibliography 0.8140819 "THECITYOFHOPE. Samuel H.Golter. G.P.Put- nam's Sons,210Madison Ave.,NewYork, N.Y.,1954." 4668 4758 W4235983626.pdf 0 52 separator 0.82563585 ¶ 4758 4760 W4235983626.pdf 0 53 bibliography 0.6527556 177pages, $3.50 4760 4776 W4235983626.pdf 0 54 paratext 0.49225459 . 4776 4777 W4235983626.pdf 0 55 separator 0.9948691 ¶ 4777 4779 W4235983626.pdf 0 56 text 0.9991896 "Thisisthestoryofthedevelopment ofthehospital at Duarte,nearLosAngeles, forthecareofpersonswith tuberculosis andcancer.According totheauthor,about40 yearsagoayoungmanofJewishextraction diedofpul- monaryhemorrhage inastreetinLosAngeles andfollow- ingthatincident fundswerecollected tohouseotherunfor- tunatepersonssuffering frompulmonary tuberculosis. ""In 1913twotentsweresetup,oneforpatients, theotherfora nurse...suchwerethehumbleandhumanitarian begin- ningsoftheCityofHope.""Thebookisintheformofaletterfromtheauthortohis daughter; itdealswiththeauthor'searlylifeintheEastern partoftheUnitedStatesandtheninLosAngeles. Ittells thestoryoftheextension oftheworkofthehospital from thecareoftuberculosis tothecareofcancer.Theauthor" 4779 5531 W4235983626.pdf 0 57 separator 0.98216087 ¶ 5531 5533 W4235983626.pdf 0 58 paratext 0.95943975 56 CALIFORNIA MEDICINE 5533 5556 W4235983626.pdf 0 0 title 0.9496254 EXOTIC BUTTERFLIES 0 18 W4243218009.pdf 9 1 separator 0.994959 ¶ 19 21 W4243218009.pdf 9 2 text 0.8851079 orpho kecuha, The Sun Butterfly 21 53 W4243218009.pdf 9 3 separator 0.9208319 ¶ 54 56 W4243218009.pdf 9 4 text 0.90469617 3/5 N atural size 56 74 W4243218009.pdf 9 0 paratext 0.9892673 Materials 2022 ,15, 1507 6 of 14 0 32 W4213048060.pdf 5 1 separator 0.5741045 ¶ 32 34 W4213048060.pdf 5 2 paratext 0.9835386 Materials 2022 , 15, x FOR PEER REVIEW 6 of 14 34 82 W4213048060.pdf 5 3 separator 0.9904647 ¶ 84 86 W4213048060.pdf 5 4 text 0.9993089 "force increased with extend ed holding time s, indicating that a short holding time is bene- ficial to extrusion forming. The punch had a certain stroke displacement during the hold- ing time due to creep." 87 298 W4213048060.pdf 5 5 separator 0.98000795 ¶ ¶ 300 306 W4213048060.pdf 5 6 caption 0.9958437 "Figure 5. Extrusion force, temperature, and stroke displacement curves during the hot extrusion at different holding times. ( a) 5 s; ( b) 60 s; ( c) 120 s; and (d) 180 s." 306 481 W4213048060.pdf 5 7 separator 0.99563944 ¶ 483 485 W4213048060.pdf 5 8 title 0.99414456 3.2. The Effect of Holding Time on the Microstr ucture Evolution of Billets 485 561 W4213048060.pdf 5 9 separator 0.9954961 ¶ 563 565 W4213048060.pdf 5 10 text 0.99971664 "The holding time caused difference s in the microstructure which affected the extru- sion force further. In order to understand the influence of the microstructure characteris- tics on the extrusion force, Figure 6 shows the billet m icrostructure at the end of each holding time under a steady clamping force of 30 Kgf. Interestingly, the billet showed three different microstructures. The prior β grain sizes in the II region were larger than that of the III region when holding for 5 s, 60 s, and 120 s. By contrast, there were only two kinds of microstructures after holding for 180 s; the grain distribution in the II region was uniform beside a few small -sized recrystallized β grains. These results can be attr ibuted to the storage energy of the original billet with a high density of LAGBs (Figure 1) [29], which provided the driving force for recrystallization in the longer hold period (180 s)." 565 1493 W4213048060.pdf 5 11 separator 0.9605602 ¶ 1494 1496 W4213048060.pdf 5 12 text 0.9996839 "The recrystallized grains gr ew rapidly at a high temperature (1200 °C) and were accom- panied by some small secondary recrystallized grains. In contrast , there was no recrystal- lization with holding times of 5 s or 60 s and there were a few initial recrystallized grains at 120 s . In each case, the lack of recrystallization was due to insufficient holding time ." 1496 1873 W4213048060.pdf 5 13 separator 0.701605 ¶ 1874 1876 W4213048060.pdf 5 14 text 0.9995825 "Moreover, the thickness of the Ι region increased with the extension of the holding time; the same was seen in the II region for holding times from 5 s to 120 s." 1876 2043 W4213048060.pdf 5 15 separator 0.9939344 ¶ 2045 2047 W4213048060.pdf 5 16 caption 0.9959788 "Figure 5. Extrusion force, temperature, and stroke displacement curves during the hot extrusion at different holding times. ( a) 5 s; ( b) 60 s; ( c) 120 s; and ( d) 180 s." 2047 2222 W4213048060.pdf 5 17 separator 0.9951978 ¶ 2222 2224 W4213048060.pdf 5 18 title 0.99441576 3.2. The Effect of Holding Time on the Microstructure Evolution of Billets 2224 2299 W4213048060.pdf 5 19 separator 0.99575907 ¶ 2299 2301 W4213048060.pdf 5 20 text 0.99970526 "The holding time caused differences in the microstructure which affected the extrusion force further. In order to understand the influence of the microstructure characteristics on the extrusion force, Figure 6 shows the billet microstructure at the end of each holding time under a steady clamping force of 30 Kgf. Interestingly, the billet showed three different microstructures. The prior grain sizes in the II region were larger than that of the III region when holding for 5 s, 60 s, and 120 s. By contrast, there were only two kinds of microstructures after holding for 180 s; the grain distribution in the II region was uniform beside a few small-sized recrystallized grains. These results can be attributed to the storage energy of the original billet with a high density of LAGBs (Figure 1) [ 29], which provided the driving force for recrystallization in the longer hold period (180 s). The recrystallized grains grew rapidly at a high temperature (1200C) and were accompanied by some small secondary recrystallized grains. In contrast, there was no recrystallization with holding times of 5 s or 60 s and there were a few initial recrystallized grains at 120 s." 2301 3499 W4213048060.pdf 5 21 separator 0.9305595 ¶ 3499 3501 W4213048060.pdf 5 22 text 0.9996779 "In each case, the lack of recrystallization was due to insufficient holding time. Moreover, the thickness of the I region increased with the extension of the holding time; the same was seen in the II region for holding times from 5 s to 120 s." 3501 3748 W4213048060.pdf 5 23 separator 0.97053456 ¶ 3748 3750 W4213048060.pdf 5 24 text 0.99973935 "As shown in Figure 7, the I region contained high-density particles with an average grains size of 3.06 m. According to the line scanning results, these grains were rich in C and Ti elements. Upon further analysis using quantitative element detection by EMPA- WDS, the average content of C in these grains was 41.2%. Thus, these gains were TiC based on the equilibrium Ti-C phase diagram [ 30], and the C originated from the graphite punch." 3750 4200 W4213048060.pdf 5 25 separator 0.9954237 ¶ 4200 4202 W4213048060.pdf 5 26 caption 0.98687613 Figure 8 presents the billet’s temperature distribution at the end of the holding time. 4202 4290 W4213048060.pdf 5 27 separator 0.99012816 ¶ 4290 4292 W4213048060.pdf 5 28 text 0.99972135 "The temperature was generated by Joule heating. It was found that the temperature gradually decreased from the billet’s upper center to the sides. The billet exhibited a radial temperature gradient due to radiation from the outer graphite mold surface. At the billet’s upper surface, the center and edge temperature difference was 62C. Relevant literature [ 31] also revealed that the radial temperature gradient inside the TiN sample was 79C during the final dwell period at 1500C. Meanwhile, the longitudinal temperature gradient inside the billet was 230C higher than the radial temperature. The cause of the longitudinal temperature gradient has two aspects. On the one hand, due to the electrical current density, the billet’s upper surface was in contact with the graphite punch, while the lower end face was in a free state (Figure 2a). On the other hand, contact resistance" 4292 5195 W4213048060.pdf 5 0 title 0.97318995 Celebrating 10 years of Chemical Science 0 40 W4235992928.pdf 0 1 separator 0.9960315 ¶ 40 42 W4235992928.pdf 0 2 text 0.9952088 "Welcome to the rst of our special anni- versary issues planned for this year,marking 10 years since Chemical Science published its rst issue, back in July 2010." 42 211 W4235992928.pdf 0 3 separator 0.79473305 ¶ 211 213 W4235992928.pdf 0 4 text 0.99915594 "We wanted to use these special birthday issues to recognise and thank members of our community who have been supporting the journal andpublishing in Chemical Science since we launched ten years ago. So we haveinvited these authors to take part in theseissues, by publishing their latest discov-eries with us. Looking to the future, wehave combined this with inviting a selec- tion of researchers who are closer to the beginning of their careers, and who arenew to publishing in Chemical Science .We hope that you enjoy reading this selection of articles, and that we cancontinue to provide an open and inclu-sive venue for both groups of researchersfor many years to come." 213 900 W4235992928.pdf 0 5 separator 0.9041677 ¶ 900 902 W4235992928.pdf 0 6 text 0.9981699 "This is also an opportunity to say thank you to all our reviewers of the journal and to our fantastic Editorial Board and Advisory Board members,both past and present, who have allcontributed to the journal over the pastten years." 902 1139 W4235992928.pdf 0 7 separator 0.9430445 ¶ 1139 1141 W4235992928.pdf 0 8 text 0.99941283 "During the planning of these issues, looking back to 2010, we realised that oneauthor, Chi-Ming Che from The Univer- sity of Hong Kong, has published an article with us in every volume since thejournal was launched. So we aredelighted that he has contributed an article again for this rst anniversary issue, and we are also taking this chanceto showcase his work on our front cover." 1141 1535 W4235992928.pdf 0 9 separator 0.8516685 ¶ 1535 1537 W4235992928.pdf 0 10 text 0.99323815 "We are sad that due to the current situation, we are unable to attend meet-ings and conferences this year to meet our authors in person. However in the spirit of this year, we wanted to take thisopportunity to introduce to you to theChemical Science Editorial team as it now looks in 2020. " 1537 1836 W4235992928.pdf 0 11 separator 0.56263983 ¶ 1836 1837 W4235992928.pdf 0 12 text 0.9956276 "We look forward to seeing you again in the near future, whether this is virtuallyor in person!" 1837 1934 W4235992928.pdf 0 13 separator 0.9745041 ¶ 1934 1936 W4235992928.pdf 0 14 contact 0.9879737 "May Copsey, Executive Editor, and the Chemical Science Editorial team" 1936 2008 W4235992928.pdf 0 15 separator 0.97743106 ¶ 2008 2010 W4235992928.pdf 0 16 paratext 0.9782824 "Cite this: Chem. Sci. , 2020, 11, 6351 DOI: 10.1039/d0sc90127j rsc.li/chemical-science" 2010 2101 W4235992928.pdf 0 17 separator 0.5933349 ¶ 2101 2103 W4235992928.pdf 0 18 paratext 0.9194837 "This journal is © The Royal Society of Chemistry 2020 Chem. Sci. ,2 0 2 0 , 11,6 3 5 1 | 6351Chemical Science" 2103 2215 W4235992928.pdf 0 19 separator 0.41658083 2215 2216 W4235992928.pdf 0 20 paratext 0.36324573 ¶ 2216 2217 W4235992928.pdf 0 21 title 0.74264413 EDITORIAL 2217 2227 W4235992928.pdf 0 22 separator 0.7553879 ¶ 2227 2229 W4235992928.pdf 0 23 paratext 0.95359766 "Open Access Article. Published on 30 June 2020. Downloaded on 5/18/2024 2:52:04 AM. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence." 2229 2404 W4235992928.pdf 0 24 separator 0.9273229 ¶ 2404 2406 W4235992928.pdf 0 25 paratext 0.3473588 View 2406 2411 W4235992928.pdf 0 26 text 0.31049162 Article 2411 2419 W4235992928.pdf 0 27 paratext 0.2912815 Online 2419 2426 W4235992928.pdf 0 28 separator 0.4794817 ¶ 2426 2428 W4235992928.pdf 0 29 paratext 0.32585883 View Journal 2428 2441 W4235992928.pdf 0 30 text 0.25513843 ¶ 2441 2443 W4235992928.pdf 0 31 paratext 0.4240618 | View Issue 2444 2457 W4235992928.pdf 0 0 math 0.52941084 p1=0×2 0 as a 0 13 W2897059229.pdf 9 1 text 0.46600226 hexadecimal number 13 32 W2897059229.pdf 9 2 math 0.6263012 ", p2=p−s0−50−9as a regular expression, p3=0−30−50−9as a regular expression, p4= unsigned integer as data type; δ10 ext vref×p1×idle,idle →fint,fdec×true,fa l s e ifvbrgis not available, " 32 233 W2897059229.pdf 9 3 table 0.37177452 ¶ 233 234 W2897059229.pdf 9 4 math 0.4695569 fint,fdec×fa l s e ,fa l s e if vbrg 234 271 W2897059229.pdf 9 5 table 0.35791877 is 271 274 W2897059229.pdf 9 6 math 0.6593615 "¶ available; δ15ext vtgt×∅×true,fa l s e → fint,fdec×true,fa l s e , vtgt×∅×fa l s e ,fa l s e → fint,fdec×fa l s e ,fa l s e ; δ14int fint,fdec×p1×true,fa l s e →fint,fdec×true,true ifvtgtis correct, fint,fdec×fa l s e ,fa l s e ifvtgtis not correct ; δ131 int fint,fdec×p2×fa l s e ,fa l s e →fint,fdec×true,true if" 274 618 W2897059229.pdf 9 7 table 0.45953864 "the comparison is correct" 618 646 W2897059229.pdf 9 8 math 0.46615025 , 646 647 W2897059229.pdf 9 9 table 0.4661851 ¶ 647 649 W2897059229.pdf 9 10 math 0.45231393 fint,fdec×fa l s e ,fa l s e if 649 681 W2897059229.pdf 9 11 table 0.37495646 "the comparison is not" 681 705 W2897059229.pdf 9 12 math 0.8012521 "correct; δ132 int fint,fdec×p3×fa l s e ,fa l s e →fint,fdec×true,fa l s e if the comparison is correct, fint,fdec×fa l s e ,true if the comparison is not correct;δ1intfint,fdec×p4×true,fa l s e→fint,fdec× true,true ; ω fint,fdec×true,true→vbrg,true , fint,fdec×fa l s e ,true→vbrg,fa l s e" 705 1016 W2897059229.pdf 9 13 separator 0.98970234 ¶ 1016 1018 W2897059229.pdf 9 14 text 0.99908215 "To realize the sequential characteristics of the logic modeling as a software, a computer network concept is applied. Figure 5 shows a schematic illustration of a networkconfiguration, which is a collection of nodes and connec- tions. The nodes are linked to each other by connections, and the connectors in the nodes are anchor points to attach connections between the nodes. For example, Node 1 corresponds to XofLMField, Node6and Node7are rele- vant to Y, and the others are represented by two transition functions: δextorδint. A major di fference from the typical computer network is that the network in Figure 5 is aone-way communication and not a two-way interaction;that is, all the connections have directions to pass the datato the node at right." 1018 1792 W2897059229.pdf 9 15 separator 0.9932231 ¶ 1792 1794 W2897059229.pdf 9 16 text 0.998012 "Figure 6 shows a class diagram for logic modeling based on the network confi guration. The DiagramViewModel visu- alizes and edits the overall modeling of a field.Nodes and Connections as properties of this class specify the collections of nodes and connections to be displayed in the logic model-ing. In NodeViewModel ,InputConnectors , and OutputCon- nectors are the collection of connectors that specify the node’s connection anchor points, and AttachedConnections retrieves a collection of the connections that are attached tothe node. The Element determines the type of the node. The ConnectionViewModel describes a connection between both-sided nodes, speci fically two connectors in each node (i.e., the SourceConnector and the DestConnector ). This con- nection continuously monitors its source and destinationconnectors. Finally, the ConnectorViewModel indicates an anchor point on a node for attaching a connection. TheParentNode in this class references the node that owns the connector." 1794 2816 W2897059229.pdf 9 17 separator 0.991601 ¶ 2816 2818 W2897059229.pdf 9 18 text 0.99318576 "Figure 7 shows the modeling execution of the bearing field previously described, that is, LM bearing . The developed software provides two views: a list view in the form of the ribbon command bar and a model view for building the model. The list view provides block libraries of modelingelements, in particular transition functions in Table 4 (thered box in Figure 7). Using the libraries, a modeler canNode" 2818 3235 W2897059229.pdf 9 19 table 0.637929 7 3235 3236 W2897059229.pdf 9 20 separator 0.8352792 ¶ 3236 3238 W2897059229.pdf 9 21 table 0.9225206 "Node6Node5 Node4 Node3Node1Node2" 3238 3275 W2897059229.pdf 9 22 separator 0.99454457 ¶ 3275 3277 W2897059229.pdf 9 23 caption 0.9917933 Figure 5: Sequential property for interpreting field.10 Complexity 3277 3343 W2897059229.pdf 9 0 title 0.72980237 Hyperosmolar Hyperglycemic State 0 32 W4212968628.pdf 8 1 separator 0.66686654 ¶ ¶ 34 40 W4212968628.pdf 8 2 paratext 0.97062165 Jurnal Syntax Fusion, Vol. 2 No.02, Februari 2022 242 40 97 W4212968628.pdf 8 3 separator 0.92101693 ¶ 98 100 W4212968628.pdf 8 4 paratext 0.6290551 (HHS). Jmj 101 112 W4212968628.pdf 8 5 bibliography 0.4921047 , 112 113 W4212968628.pdf 8 6 paratext 0.7202005 7(2), 151 –160. Google Scholar 113 144 W4212968628.pdf 8 7 separator 0.9890543 ¶ 146 148 W4212968628.pdf 8 8 bibliography 0.9972872 Zamri, A., & Rahayu Oktaliani, H. (n.d.). Diabetes & its Complications . Google Scholar 148 236 W4212968628.pdf 8 9 separator 0.85879517 "¶ ¶ ¶" 238 252 W4212968628.pdf 8 10 paratext 0.8184138 "First publication right: Jurnal Syntax Fusion: Jurnal Nasional Indonesia ¶ This article is licensed under: ¶ ¶" 252 385 W4212968628.pdf 8 11 separator 0.75662017 ¶ ¶ 387 393 W4212968628.pdf 8 0 paratext 0.98968345 Sustainability 2018 ,10, 2519 11 of 18 0 38 W2884544184.pdf 10 1 separator 0.9953802 ¶ 38 40 W2884544184.pdf 10 2 text 0.9995526 "For H5–H7, a one-way between-groups analysis of variance is conducted to see if the responses to ‘company XY is a sustainable company’ differ (Table 6). There is a significant difference at p< 0.01 between the four groups: F(3, 125) = 4.3, p= 0.006. The result supports H5. The post-hoc test shows that the significant differences are between the country combinations (2) and (3) (0.014), as well as (2) and (4) (0.011). Looking at the mean plots, it is interesting that country combination (2) has the highest mean score (M: (2) = 2.13; (1) = 1.68; (3) = 1.48; (4) = 1.47), meaning that the group with the lowest spatial distance, for the focal company as well as supplier, receives on average better results for the perception of the company’s sustainability than combinations with higher distance, which supports H6 and H7. Additionally, the partial eta squared effect size is calculated to show how strongly the independent variable can explain the variance of the dependent variable. According to Cohen [ 53], there is a small effect at 0.01, a medium effect at 0.06 and a large effect at 0.14. This analysis shows an effect of 0.0936 or 9%, resulting in a medium to large effect." 40 1246 W2884544184.pdf 10 3 separator 0.9966705 ¶ 1246 1248 W2884544184.pdf 10 4 title 0.91865015 Table 6. ANOVA Results. 1248 1272 W2884544184.pdf 10 5 separator 0.47871783 1272 1273 W2884544184.pdf 10 6 table 0.98046154 "¶ ‘Company XY Is a Sustainable Company’ Sum of Squares df Mean Square F Sig. Between Groups 8945 3 2982 4301 0.006 Within Groups 86,652 125 693 Total 95,597 128" 1273 1441 W2884544184.pdf 10 7 separator 0.9888898 ¶ 1441 1443 W2884544184.pdf 10 8 text 0.9993396 "Finally, a linear regression helps to test H8. The country of the supplier and the focal company are tested separately to detect possible differences. None of the R2values explain more than 9% of the variance in the models. Looking at the output summary in Table 7, no significant results are found, and therefore, H8 cannot be supported." 1443 1787 W2884544184.pdf 10 9 separator 0.9966888 ¶ 1787 1789 W2884544184.pdf 10 10 title 0.6147997 Table 7. Results linear regression ( 1789 1826 W2884544184.pdf 10 11 table 0.66036785 significant at p< 0.05; FC = focal company). 1826 1869 W2884544184.pdf 10 12 separator 0.642035 ¶ 1869 1871 W2884544184.pdf 10 13 table 0.99443215 "Group Country of_ R R2B (Constant) B (Independent Variable) 1FC 0.053 0.003 1.587 0.036 Supplier 0.189 0.036 1.149 0.146 2FC 0.3 0.09 0.903 0.444 Supplier 0.199 0.039 0.913 0.337 3FC 0.183 0.034 1.016 0.148 Supplier 0.132 0.017 1.200 0.133 4FC 0.186 0.035 1.939 (" 1871 2149 W2884544184.pdf 10 0 paratext 0.76464295 B-CELL DEVELOPMENT INPEYER'S PATCHES 265 0 40 W2028801513.pdf 2 1 separator 0.9927678 ¶ 40 42 W2028801513.pdf 2 2 text 0.9971128 "thethymus todexamethasone following dailyinjec- tionsof2mg/kgBWfor3,5,or7days;4groups of 4lambs wereusedtoevaluate theresponses ofthe PPs,thymus, andbloodlymphocyte populations following daily injections of2mg/kgBWdexa- methasone for7consecutive days.Onegroup of4 lambswasusedtostudy theresponses oflymphoid tissues during eachofthefollowing posttreatment intervals: days1-10;days1-28;days1-52;and days1-98.of20mg/kgBW30minprior tocollecting tissues." 42 511 W2028801513.pdf 2 3 separator 0.79387105 ¶ 511 513 W2028801513.pdf 2 4 text 0.9995279 "Thisprocedure resulted inadetectable levelofBrdU incorporation in40-45% iPfB-cells and8-10% of thymocytes (Griebel andFerrari, 1995). Immuno- peroxidase detection ofBrdUincorporated intissue sections wasperformed aspreviously described (Griebel andFerrari, 1994)." 513 787 W2028801513.pdf 2 5 separator 0.9933558 ¶ 787 789 W2028801513.pdf 2 6 title 0.9902504 RESULTS 789 797 W2028801513.pdf 2 7 separator 0.9958766 ¶ 797 799 W2028801513.pdf 2 8 title 0.7652124 "Tissue Collection, CellIsolation, Immunohistochemistry" 799 856 W2028801513.pdf 2 9 text 0.7414172 ( 856 858 W2028801513.pdf 2 10 title 0.74571323 "IHC), andFlow Cytometry" 858 883 W2028801513.pdf 2 11 separator 0.9784195 ¶ 883 885 W2028801513.pdf 2 12 text 0.9995379 "Blood collected inEDTA wasusedtodetermine total white cellcounts, differential counts ofleukocytes, andtoisolate mononuclear cellswithadiscontinu- ousPercoll gradient (Griebel andFerrari, 1995). Cell suspensions wereprepared fromlymphoid follicles ofthePPandother tissues asdescribed previously (Griebel andFerrari, 1995; Griebel etal.,1994)." 885 1240 W2028801513.pdf 2 13 separator 0.9301191 ¶ 1240 1242 W2028801513.pdf 2 14 text 0.99938303 "Tissues forhistology were firstfixedinphosphate- buffered formaldehyde (12%)prepared inmethanol andthendehydrated ingraded ethanol before em- bedding inTechnovit 7100medium (Heraeus Kulzer, Wehrheim, Germany). Tissue sections, 1-1.5mthick,weremounted onprecleaned glassslides, heated at70Cfor1hrandthenstained for3min with1%threonine-acetate (Fluka) prepared indis- tilledH20. Tissues forIHCwereplaced incryo- molds (Tissue-Tek II;Lab-Tek Products, Nunc Inc., Naperville, IL)andmucosal surfaces werecovered withathinsliceofliverbeforeembedding inO.C.T. compound (Miles Lab. Inc.,Naperville, IL)and freezing ondryice.Themethods forindirect label- ingofcellsuspensions forflowcytometric analysis (FACScan; Becton Dickinson, Mountain View,CA), cellsorting (FACStar Plus,Becton Dickinson), and indirect immunoperoxidase staining offrozen tissue sections havepreviously beendescribed indetail (Griebel etal.,1994; Griebel andFerrari, 1995). To quantitate lymphocyte subpopulations inblood, the totalnumber ofbloodmononuclear cells/ml blood wasmultiplied bythepercent mononuclear cells labeled bytheappropriate mAbanddetected with flowcytometric analyses." 1242 2438 W2028801513.pdf 2 15 separator 0.99683 ¶ 2438 2440 W2028801513.pdf 2 16 title 0.9907802 BrdUIncorporation andDetection 2440 2471 W2028801513.pdf 2 17 separator 0.9945971 ¶ 2471 2473 W2028801513.pdf 2 18 text 0.98441046 "BrdUwasdissolved in60CPBS,cooled toroom temperature, andinjected ivatafinalconcentrationDexamethasone-Induced Involution ofPrimary" 2473 2606 W2028801513.pdf 2 19 separator 0.4989453 ¶ 2606 2608 W2028801513.pdf 2 20 title 0.79036963 Lymphoid T 2608 2619 W2028801513.pdf 2 21 text 0.6659201 issues 2619 2625 W2028801513.pdf 2 22 separator 0.9772366 ¶ 2625 2627 W2028801513.pdf 2 23 text 0.9996485 "Preliminary experiments werecompleted todeter- mine ifdexamethasone induced involution ofpri- marylymphoid tissues inyoung lambs. Thethymus wasused asacontrol organ because ofitswell- characterized corticosteroid sensitivity inmice(Ishi- dateandMetcalf, 1963;Clamen etal.,1971). The effect ofdexamethasone treatment onthethymus andilealPPwasfirstevaluated with0.02,0.2,and 2mgdexamethasone/kg BWadministered for3 consecutive days. IlealPPhistology andthymic weights wereevaluated withtissues collected 24hr afterthelasttreatment. Amarked reduction in thymic weight (40-60% decrease) andilealPP follicular sizeandcellularity wasobserved atall doses ofdexamethasone, butwith2mg/kg, few follicular Bcellswereseenontissue sections (data notshown). Threelambweretheninjected with2 mgdexamethasone/kg BWfor3,5,and7days,and tissues werecollected 24hraftereachtreatment and 30minafterinjecting BrdU.FewBrdU cellswere detected inilealPPfollicles following dexametha- sonetreatment for3days,andnodetectable BrdU incorporation wasobserved following the7-day treatment (datanotshown). Thus, a7-day treatment with2mgdexamethasone/kg BWwaschosen to study thelong-term effects ofarrested iPfB-cell proliferation. Thisdexamethasone treatment regime resulted inamarked reduction inthymic cortex with arelative increase inthemedullary region (Fig.lb), butdidnotarrest proliferation ofcortical thymo- cytes (Fig.2b).Thymic weights foruntreated, age- matched lambs were58.6+7.2g(mean +S.D.of values from5lambs), butduring thefirst2weeks postdexamethasone, theaverage thymic weights were 12.8+3.2g(n 5lambs). Theeffects of dexamethasone onthymic architecture andthymo- cyteproliferation werenolonger evident 4-5weeks posttreatment (Fig.2c)." 2627 4421 W2028801513.pdf 2 24 separator 0.9972162 ¶ 4421 4423 W2028801513.pdf 2 0 paratext 0.76277965 Vaccine xxx (xxxx) xxx 0 22 W4386885173.pdf 2 1 separator 0.99354196 ¶ 22 24 W4386885173.pdf 2 2 text 0.99624765 "3nonclinical development program while data supported the dose and regimen approved for human use. The NVX-CoV2373 safety profile in- dicates this vaccine is well tolerated as demonstrated by data from over 31,000 participants receiving NVX-CoV2373 across 5 randomized controlled clinical trials." 24 332 W4386885173.pdf 2 3 separator 0.97052336 ¶ 333 335 W4386885173.pdf 2 4 text 0.9993968 "The most frequent adverse reactions from the clinical trials were injection site tenderness, injection site pain, fatigue, myalgia, headache, malaise, arthralgia, nausea or vomiting. These adverse reactions were usually mild to moderate in severity with a median duration of less than or equal to 2 days. These local and systemic adverse reactions occurred more frequently after Dose 2 than after Dose 1 [5]." 335 759 W4386885173.pdf 2 5 separator 0.92846525 ¶ 760 762 W4386885173.pdf 2 6 text 0.9987754 "Additionally, there has been no evidence of vaccine-associated enhanced disease following administration in multiple animal species and in humans during clinical development and in the post authoriza - tion setting." 762 986 W4386885173.pdf 2 7 separator 0.9897105 ¶ 987 989 W4386885173.pdf 2 8 text 0.9995848 "Myocarditis and/or pericarditis are safety concerns of interest with all COVID-19 vaccines. In clinical trials, 2 events of myocarditis were reported in the NVX-CoV2373 group, and 1 event was reported in the placebo group during the pre-crossover period, with a risk difference of 0 (95% CI," 989 1290 W4386885173.pdf 2 0 paratext 0.961081 Activator of Carbon Dioxide Absorption By Chlorophyll-Synthesizing Microalgae 65 0 80 W2970972875.pdf 2 1 separator 0.9701075 ¶ 80 82 W2970972875.pdf 2 2 title 0.9863146 "3. Presentation of the main material and discussion of the results" 82 153 W2970972875.pdf 2 3 separator 0.9897449 ¶ 154 156 W2970972875.pdf 2 4 text 0.9996802 "The object of the laboratory research was Chlorella – the culture of green microalgae. For this purpose water was taken from the pond where the standard nutrient medium was introduced, and a culture of microalgae Chlorella was added. Cultivation was has been carried out for 11 days in six phyto-bioreactors with the volume of 1liter. Nutrients – carbon dioxide and mineral nutrition elements of the microalgae cells were obtained directly from the environment by bubbling, absorbing them with their entire surface. Since nitrogen dioxide is absorbed by micro-algae in the form of anion , for the study of the effect of nitrogen oxides on the growth of chlorophyll-synthesizing microalgae, an anion with the concentration of 1.7 mg/m3 was added to the first volume, 3.4 mg/m3 – to the second, 8,5 mg/m3 – to the third, 15.6 mg/m3 – to the fourth, 34 mg/m3 to the fifth, and 68 mg/m3 to the sixth one. The growth of biomass chlorophyll-synthesizing microalgae under these conditions was determined by a photo-colorimetric method using a blue light filter according to Bouguer-Lambert-Ber." 156 1302 W2970972875.pdf 2 5 separator 0.93219864 ¶ 1303 1305 W2970972875.pdf 2 6 text 0.9996786 "Since the optical density is proportional to the concentration of algae, which is confirmed by the calibration graph, therefore the experimental data on the accumulation of algae biomass depending on the time within the studied nitrogen oxide concentration (N xOy) correspond to the value of optical densities [5]." 1305 1635 W2970972875.pdf 2 7 separator 0.9521351 ¶ 1636 1638 W2970972875.pdf 2 8 text 0.99957913 "By the change in the concentration of cells (number of cells per unit volume of suspension) or the density of microorganisms (dry weight of microorganisms per volume unit of suspension) the rate of growth of microalgae was determined. Based on the results of experimental data and calculation values, graphically dependent changes in the concentration of algae cells in time at the appropriate concentrations of nitrogen oxides (NxOy) in a solution under the conditions of their single injection were obtained (Fig. 2.1, Fig. 2.2)." 1638 2197 W2970972875.pdf 2 9 separator 0.9668644 "¶ ¶" 2198 2208 W2970972875.pdf 2 10 caption 0.9943309 "Fig. 2.1. Dependence of the change in the concentration of cells of algae in time at appropriate concentrations Fig. 2.2. Dependence of the change in the concentration of cells of algae in time at appropriate concentrations" 2208 2441 W2970972875.pdf 2 11 separator 0.9470899 ¶ ¶ 2443 2449 W2970972875.pdf 2 12 text 0.99947995 "Analyzing the data (Fig. 2.1, Fig. 2.2), it should be noted that the increase in the concentration of microalgae cells significantly depends on the concentration of nitrogen oxides (N xOy) compared with the control, which did not contain oxides of nitrogen." 2449 2719 W2970972875.pdf 2 13 separator 0.7470777 ¶ 2720 2722 W2970972875.pdf 2 14 text 0.9992915 "Under such conditions, the growth of microalgae in a liquid medium that is well stirred varies over time, depending on the concentration of nitrogen oxides." 2722 2885 W2970972875.pdf 2 15 separator 0.8860224 ¶ 2886 2888 W2970972875.pdf 2 16 text 0.9996537 "As the concentration of nitrogen oxides increases (NxOy), the growth of the algae cells increases, but to a certain value. As shown in (Fig. 2.2) the sixth test on the second day behaves in the same way as others, that is, it also adapts, and from the third day the growth begins, which even on the fifth day is higher than in the control sample, but from the sixth day there is a decline and in the next five days neither growth nor death of microalgae is observed. A similar dynamics, but with a lower concentration, is also observed in a control tank that has not been exposed to nitrogen oxides (NxOy)." 2888 3522 W2970972875.pdf 2 17 separator 0.9844965 ¶ 3523 3525 W2970972875.pdf 2 18 text 0.96076953 "The main parameter characterizing the growth of microalgae Δk is a specific growth rate: ∆k=∆C /С×∆Т , (2) where ∆C is the increase in the concentration of microalgae, С is the concentration of microalgae, ∆k is specific growth rate or coefficient of growth rate ( с-1). On the other hand, the coefficient of growth can be determined from the equation [6]: dC/dt=k×C. (3)" 3525 3984 W2970972875.pdf 2 19 separator 0.5315835 ¶ 3985 3987 W2970972875.pdf 2 20 text 0.99929774 "According to this equation, the growth factor characterizes the relative increase in the density of algae per time unit. If for some time Δk remains unchanged, then such increase is called exponential, and the corresponding time interval is the exponential growth phase [7]." 3987 4277 W2970972875.pdf 2 0 paratext 0.94091046 "Jurnal Teknologi dan Manajemen Informatika (JTMI) Vol.9 No.2 Tahun 20 23 : 119-128 ¶ [128]" 0 99 W4390888173.pdf 9 1 separator 0.9927825 ¶ 100 102 W4390888173.pdf 9 2 bibliography 0.99798334 "[3] R. Daroya, D. Peralta, and P. Naval, ""Alphabet Sign Language Image Classification Using Deep Learning,"" presented at the Conf. Proceedings TENCON, 2018." 103 263 W4390888173.pdf 9 3 separator 0.8226735 ¶ 265 267 W4390888173.pdf 9 4 bibliography 0.9977469 "[4] Darmatasia, ""Pengenalan Si stem Isyarat Bahasa Indonesia (SIBI) Menggunakan Gradient -Convolutional N eural Network,"" Jurnal Informatika Sains dan Teknologi (INSTEK), vol. 6, 2021." 267 458 W4390888173.pdf 9 5 separator 0.9270172 ¶ 460 462 W4390888173.pdf 9 6 bibliography 0.997897 "[5] S. Dwijayanti, Hermawati, S. I. Taqiyyah, H. Hikmarika, and B. Y. Suprapto, ""Indonesia Sign Language Recognition using Convolutional Neural Network,"" International Journal of Advanced Computer Science and Applications (IJACSA), vol. 12, 2021." 462 716 W4390888173.pdf 9 7 separator 0.92311484 ¶ 718 720 W4390888173.pdf 9 8 bibliography 0.9978805 "[6] V. R. S. Nastiti, R. A. Muhammad, and B. P. Putra, ""Pendeteksi Bahasa Isyarat Gestur Tangan dengan Menggunaka n Model CNN ResNet50V2,"" Rekayasa Sistem dan Teknologi Informasi (RESTI), vol. 6, 2022." 720 929 W4390888173.pdf 9 9 separator 0.9439666 ¶ 931 933 W4390888173.pdf 9 10 bibliography 0.99773157 "[7] H. P. A. Tjahyaningtijas, W. Yustanti, and A. Prihanto, ""Analisa Learning rate dan Batch size Pada Klasifikasi Covid Menggunakan Deep learning dengan Optimizer ADAM ,"" Journal Information Engineering and Educational Technology (JIEET), vol. 5, 2021." 933 1193 W4390888173.pdf 9 11 separator 0.939016 ¶ 1195 1197 W4390888173.pdf 9 12 bibliography 0.9977838 "[8] F. Zhang et al. , ""MediaPipe Hands:On -device Real -time Hand Tracking,"" presented at the CVPR Workshop on Computer Vision for Augmented and Virtual Reality, Seattle, USA , 2020." 1197 1387 W4390888173.pdf 9 13 separator 0.9081694 ¶ 1389 1391 W4390888173.pdf 9 14 bibliography 0.99796146 "[9] Indriani, M. Harris, and A. S. Agoes, ""Applying Hand Gesture Recognition for User Guide Application Using MediaPipe,"" in Proceedings of the 2nd International Seminar of Science and Applied Technology (ISSAT 2021) , 2021, vol. 207." 1391 1634 W4390888173.pdf 9 15 separator 0.9318215 ¶ 1636 1638 W4390888173.pdf 9 16 bibliography 0.9978796 "[10] M. K. H ossen and M. S. Uddin, ""A dataset for Assessing Real -time Aattention Leve ls of the Students During Online Classes,"" Data in Brief, vol. 51, 2023." 1638 1802 W4390888173.pdf 9 17 separator 0.91500664 ¶ 1804 1806 W4390888173.pdf 9 18 bibliography 0.99762595 "[11] P. A. Nugroho, I. Fenriana, and R. Arijanto, ""Implementasi Deep Learning Menggunakan Convolutional Neural Network (CNN) pada Ekspresi Manusia,"" ALGOR Journal, vol. 2, 2020." 1806 1991 W4390888173.pdf 9 19 separator 0.91546905 ¶ 1993 1995 W4390888173.pdf 9 20 bibliography 0.99781924 "[12] M. Reyad, A. M.Sarhan, and M.Arafa, ""A Modified ADAM Algorithm for Deep Neural Network Optimization,"" Neural Computing and Applications, vol. 35, pp. 17095 -17112, 2023." 1995 2177 W4390888173.pdf 9 21 separator 0.9465757 ¶ 2179 2181 W4390888173.pdf 9 22 bibliography 0.99789953 "[13] D. Irfan, R. Rosnelly, M. Wahyni, J. T. Samudra, and A. Rangga, ""Perbandingan Optimasi SGD, ADADELTA dan ADAM Dalam Klasifikasi Hydrangea Menggunakan CNN,"" Journal of Science and Social Research, vol. 5, pp. 244 -253, 2022." 2181 2418 W4390888173.pdf 9 23 separator 0.9321637 ¶ 2420 2422 W4390888173.pdf 9 24 bibliography 0.9978962 "[14] F. D. Telaumbanua, P. Hulu, T. Z. Nad eak, R. R. Lumbantong, and A. Dharma, ""Penggunaan Machine Learning Di Bid ang Kesehatan,"" Jurnal Teknologi dan Ilmu Komputer Prima (Jutikomp), vol. 2, 2020." 2422 2628 W4390888173.pdf 9 25 separator 0.93365943 ¶ 2630 2632 W4390888173.pdf 9 26 bibliography 0.997578 "[15] L. B. Ardianto, M. I. Wahyuddin, and W. Winarsih, ""Implementasi Deep Learning untuk Sistem Keam anan Data Pribadi Menggunakan Pengenalan Wajah dengan Metode Eigenface Be rbasis Android,"" Jurnal Teknologi Informasi dan Komunikasi (JTIK), vol. 5, 2021." 2632 2897 W4390888173.pdf 9 27 separator 0.94344926 ¶ 2899 2901 W4390888173.pdf 9 28 bibliography 0.9978213 "[16] T. Israldi and E. H. S. S. F. Syafria, ""Klasifikasi American Sign Language Menggunakan Convolutio nal Neural Network,"" Building of Informatics, Technology and Science (BITS), vol. 4, 2022." 2901 3101 W4390888173.pdf 9 29 separator 0.99217904 ¶ 3103 3105 W4390888173.pdf 9 0 text 0.9996425 "atypical clinical manifestations or in those who cannot be diagnosed by biochemical tests. PORD is an autosomal recessive disorder, and most patients have compound heterozygous mutations in POR. The genetic polymorphisms inPOR have signi ficant racial and individual differences. About 200 POR mutations and single nucl eotide polymorphisms (SNPs) have been reported to date. Among the types of missense mutations, A287P is the most common POR mutation in Caucasians, R457H is highly prevalent in Japanese population ( 16), while A503V is also common in POR, with a prevalence of about 27% in the general population ( 17)." 0 641 W4310249268.pdf 8 1 separator 0.9816655 ¶ 641 643 W4310249268.pdf 8 2 text 0.9991484 "We also reviewed the clinical d ata of 20 previously reported Chinese patients with PORD ( 17–26)( 1 2f e m a l ep a t i e n t s )( Table 3 )." 643 788 W4310249268.pdf 8 3 separator 0.96727824 ¶ 788 790 W4310249268.pdf 8 4 text 0.9995522 "After exclusion of patients with missing data, we found that 19 of 19 included patients had abnormal sec retion of steroid hormones, 18/ 19 patients had external genital deformities, 8/19 patients had skeletal deformities, and 10/16 pa tients had maternal virilisation." 790 1066 W4310249268.pdf 8 5 separator 0.818691 ¶ 1066 1068 W4310249268.pdf 8 6 text 0.9993933 "Among the 12 pubertal patients, 6/12 cases had delayed puberty, 8/ 1 2c a s e sh a dd e l a y e dg r o w t h ,a n d8 / 1 2c a s e sh a do v a r i a nc y s t s ." 1068 1231 W4310249268.pdf 8 7 separator 0.98576915 ¶ 1231 1233 W4310249268.pdf 8 8 text 0.9994053 "Understanding of these clinical characteristics can improve a w a r e n e s so fP O R Da sw e l la st h ee t iological differentiation of CAH. From the above summary, it can be seen that PORD patients mainly present with varying degr ees of abnormal steroid hormone secretion and external genital malformations at birth. And they may habe growth and developmental delays in adulthood, which could be misdiagnosed as other subtypes of CAH. PORD should be considered if patients also ha ve skeletal malformations or virilisation symptoms during pregnancy." 1233 1803 W4310249268.pdf 8 9 separator 0.9736439 ¶ 1803 1805 W4310249268.pdf 8 10 text 0.999736 "Among the 20 reported PORD cases in China, 8 cases (8/20) had a mutation at p.R457H, 3 cases (3/7) had a homozygous mutation, and 4 cases (4/7) were compound heterozygote for this mutation, with exlusion of 1 case with missing data. This suggests that p.R457H is a hot-spot mutation in the Chinese population, which is similar to the results reported in other countries. The affected child in our case-series was compound heterozygous for mutations in POR: the c.1370 G>A (p.R457H) variant from the mother has been reported as a pathogenic variant in multiple PORD cases, while the c.1379 C>A(p.S460Y) variant from the father has not been reported to date. This variant is “likely pathogenic ”according to the American College of Medical Genetics guideline for variant classi fication (PMID: 25741868). Current bioinformatics analysis suggests that it is necessary to investigate the relationship between the novelmutation site and changes in enzyme function and activity further, to con firm that this genetic change leads to changes in enzyme activity." 1805 2890 W4310249268.pdf 8 11 separator 0.9872118 ¶ 2890 2892 W4310249268.pdf 8 12 text 0.9997426 "In terms of treatment, multidisciplinary cooperative management is required for PORD. High-risk populations for PORD should be identi fied and screened ( 27). The patient in this study demonstrated virilisati on during pregnancy, but the clinician ’s lack of awareness of the disease led to a family tragedy." 2892 3208 W4310249268.pdf 8 13 separator 0.9745252 ¶ 3208 3210 W4310249268.pdf 8 14 text 0.9997047 "If timely detection and prenatal diagnosis were implemented, adverse outcomes could be avoided. Careful attention should bepaid to the following populations: those with a family history of CAH or PORD; those with maternal v irilisation during pregnancy; those with hermaphroditism or skeletal deformity after birth; and those with delayed puberty development. Tests for relatedhormones and metabolites can be performed in these populations. Genetic testing is helpful for early diagnosis and differential diagnosis of PORD. In a large number of asymptomatic patients (homozygo us or compound heterozygotes for autosomal recessive inheritance) and PORD gene carriers (heterozygotes for autosomal rece ssive inheritance), the disease is more likely to be missed. Typica lly, mothers with PORD foetuses have low serum estriol levels, which may be detected during the triple antenatal screening test. S ubsequent maternal urinalysis may reveal characteristic manifestat ions of aberrant steroid precursors, which can facilitate a prenatal diagnosis ( 13,28). It is necessary to inform mothers that, once virilisa tion occurs during pregnancy, it should be dealt with as soon as possible. Preconception health education and genetic counselli ng are required for patients with confirmed PORD or in the above-menti oned high-risk populations." 3210 4581 W4310249268.pdf 8 15 separator 0.9897348 ¶ 4581 4583 W4310249268.pdf 8 16 text 0.99968374 "Patients with con firmed PORD need individu alised guidance for better natal and prenatal care. It is recommended that spouses should undergo genetic testing to screen for heterozygous cases before conception, or genetic diagnosis should be performed before embryo implantation. Prenatal genetic screening or amniotic fluid cell testing under ultrasonic should be performed during pregnancy for early identi fication of foetuses with disease genes and for managing the corresponding risks. For neonates born with hermaphroditism or character istic skeletal deformities, chromosomal examinations are required to determine the genetic sex. Genetic testing is helpful in diagnosing PORD and distinguishing it fr om other types of CAH. Adrenal gland (blood ACTH, cortisol, electrolytes, and acid –base balance) and gonadal function should be evaluated in aff ected children, and the detection items that cannot be assessed but that have important diagnostic value (such as 17-hydroxyprogeste rone) should be tested elsewhere before treatment. Timely diagnosis and treatment can avoid severe dehydration, electrolyte imbalance , and adrenal cortical crisis, and thus reduce mortality. The patient(i.e. the mother) should be informed of the need for long-term follow-up after birth, with re- examination of 17-hydroxyprogesterone in 2 weeks. Continued increase in blood 17-hydroxyprogesterone concentration is an important diagnostic indicator of 21-OHD. For patients diagnosed in puberty, ACTH stimulation test should be used todetermine the degree of glucocorticoid de ficiency. Glucocorticoids should be supplemented as appropriate, and drugs should be administered to improve and restore the patient ’s secondary sexual characteristics in pub erty. If necessary, orthopaedic treatment is needed." 4583 6427 W4310249268.pdf 8 17 separator 0.98927 ¶ 6427 6429 W4310249268.pdf 8 18 text 0.9839872 "In conclusion, PORD is a group of autosomal recessive genetic disorders. Case 1(the mother) presented signs of virilisation during pregnancy in female foetus, and gave born to a male infant with PORD and a female infant with suspected PORD, and did not receive a timely and precise diagnosis.Zhang et al. 10.3389/fendo.2022.1020880" 6429 6769 W4310249268.pdf 8 19 separator 0.97800136 ¶ 6769 6771 W4310249268.pdf 8 20 paratext 0.9789636 Frontiers in Endocrinology frontiersin.org 09 6771 6817 W4310249268.pdf 8 0 text 0.9994949 "118а платья , отрезы тканей , белые вышитые головные уборы «кIазы», сложив аккуратно , накидывали на специальную жердь – «чахлух », укрепленную горизонтально в комнате молодоженов у одной из ее стен, ближе к потолку , с помощью веревок , свисающих с него . А те из вещей , которые не успели расставить или уложить нужным образом , оставались в таком положении до истечения 40 дней . После 40 дней , прошедших со дня свадьбы , в доме молодоженов снова собирались женщины -родственницы , чтобы совершить обряд «чахлух чикабулчне » – в торжественной обстановке после соответствующей трапезы снимали с жерди платья и все, что на ней находилось . Причем часть из них, специально выделенную родителями новобрачной и предварительно оговоренную , раздавали родственницам мужа новобрачной . Обычно это головные уборы «кIазы», отрезы тканей . А остальное клали в сундук , полученный новобрачной от ее родителей в качестве приданого . Тогда же окончательно расставляли по полкам и вешали на стену посуду (фарфор , фаянс , металлические сосуды )." 0 1148 W4255794743.pdf 3 1 separator 0.9903067 ¶ 1149 1151 W4255794743.pdf 3 2 text 0.99928564 "К 7 и 40 дням приурочивались также обряды , связанные с рождением первого ребенка . По истечении 7 дней со дня его рождения бабушка по матери готовила для своего внука или внучки люльку . Ее заранее заказывали мастеру или покупали готовую . На восьмой день мать относила полностью снабженную всеми необходимыми принадлежностями (матрацы , одеяло , подушечка , накидка и т.д.) люльку к своей дочери , у которой родился ребенок . Вместе с люлькой несли еще еду примерно на 10−15 человек – плов , чуду , курзе и др." 1151 1721 W4255794743.pdf 3 3 separator 0.9815831 ¶ 1722 1724 W4255794743.pdf 3 4 text 0.9925469 "В этот же день у молодоженов собирались приглашенные родственники – мужчины и женщины , которые приносили с собой подарки для ребенка , обычно одежду . Все собравшиеся осматривали люльку и давали ей оценку – хорошую или посредственную . После этого угощали всех собравшихся . Одна из ближайших родственниц отца или матери ребенка , или сама бабушка ребенка , принесшая люльку , торжественно в присутствии всех участников обряда укладывала ребенка в люльку . При этом она сначала произносила мусульманскую формулу «бисмилла », а затем пела одну из кубачинских колыбельных песен (Абакарова Ф.О., 1996. С. 127). Весь этот обряд , который бытует и ныне , носит название «гал лакьуйле видихьне » – укладывание ребенка в люльку . Если в люльку укладывали мальчика , то процедура носила более торжественный характер , чем укладывание девочки . При совершении этого обряда давали и имя ребенку ." 1724 2712 W4255794743.pdf 3 5 separator 0.99045664 ¶ 2714 2716 W4255794743.pdf 3 6 text 0.9993473 "До истечения 40 дней со дня рождения ребенка обычно не выносили из дома , кроме как на лоджию , балкон или закрытый дворик ; не ходили с ним к соседям или друзьям . На этот счет и ныне существует поговорка : «Гал агъц Iале ухакал таигъегъу » – пока не исполнится 40 дней , ребенка не выводят из дома ." 2716 3045 W4255794743.pdf 3 7 separator 0.979915 ¶ 3046 3048 W4255794743.pdf 3 8 text 0.99942654 "На 40-й день мать вместе с ребенком ходила к бабушке ребенка , которая собирала по этому случаю своих родственников и ближайших соседей . Гостей угощали специально приготовленной для этой цели едой , а те поздравляли мать и бабушку ребенка с исполнением ему 40 дней . Бабушка дарила внуку (внучке ) что- нибудь – одежду или украшения . Данный обряд носит название «гал таагъи » – вывести ребенка [из дома ]. В обряде участвовали и мужчины , которые собирались у дедушки ребенка по матери отдельно от женщин . В прошлом же в обряде участвовали только женщины ." 3048 3675 W4255794743.pdf 3 9 separator 0.9865358 ¶ 3676 3678 W4255794743.pdf 3 10 text 0.9992802 "Как было отмечено , числа 7 и 40 фигурируют и в похоронных обрядах . До истечения 40 дней после смерти близкого человека в каждую пятницу вечером готовили халву («бахъухъ »). Ее ели совместно с родственниками и близкими умершего . После смерти близкого человека 40 дней продолжался траур . В течение 40 дней родные и близкие умершего носили траурную одежду , не веселились , не" 3678 4099 W4255794743.pdf 3 0 text 0.9878962 "S20multiple washout technique (NMBW) in ALI/ARDS patients, and to set PEEP levels on data of FRC values." 0 106 W2079251542.pdf 19 1 separator 0.994993 ¶ 106 108 W2079251542.pdf 19 2 title 0.9582007 Methods 108 116 W2079251542.pdf 19 3 text 0.9983213 "Twenty patients with ALI/ARDS were enrolled in the study. All patients were ventilated in pressure-controlled ventilation with an Engstrom carestation ventilator (GE Healthcare, Helsinki, Finland) in accordance with the ARDSnet guidelines. FRC measurement was carried out with the COVX module integrated within the ventilator (GE Healthcare) by a NMBW technique. Every patient had a basal FRC measurement and then three measurements at PEEP 15/10/5 cmH2O during a derecruiting maneuver. After all measurements, PEEP was set as the PEEP at which value FRC started to decrease. At basal time (T0) and after setting the best PEEP (T1) the PaO2/FIO2 ratio and static compliance were measured too. All data are reported as the mean ± SD. A ttest was used to compare changes during time." 116 920 W2079251542.pdf 19 4 separator 0.9961121 ¶ 920 922 W2079251542.pdf 19 5 title 0.7482242 Results 922 930 W2079251542.pdf 19 6 text 0.96235543 Table 1 presents the main results of the study. 930 978 W2079251542.pdf 19 7 separator 0.9889221 ¶ 978 980 W2079251542.pdf 19 8 table 0.9901387 "Table 1 (abstract P48) Parameter T0 T1 FRC (ml) 2,330 ± 400 2,933 ± 300* PaO2/FiO2 164 ± 74 251 ± 107* Compliance (ml/cmH2O) 38 ± 12 49 ± 15* *P<0.05 T1 vs. T0." 980 1152 W2079251542.pdf 19 9 separator 0.9881953 ¶ 1152 1154 W2079251542.pdf 19 10 title 0.87527895 Conclusions 1154 1166 W2079251542.pdf 19 11 text 0.9913567 "FRC measurement by the NMBW technique integrated in the ventilator is useful to assess functional lung impairment at the bedside. Setting PEEP on FRC measurements may improve lung recruitment and oxygenation, but anatomical studies (CT scan) are also warranted." 1166 1436 W2079251542.pdf 19 12 separator 0.9949738 ¶ 1436 1438 W2079251542.pdf 19 13 bibliography 0.66314876 Reference 1438 1448 W2079251542.pdf 19 14 separator 0.83778286 ¶ 1448 1450 W2079251542.pdf 19 15 bibliography 0.98352575 "1. Lambermont B, et al .: Comparision of functional residual capacity and static compliance of the respiratory system during a PEEP ramp procedure in an experimental model of acute respiratory distress syndrome. Crit Care 2008, 12:R91." 1450 1695 W2079251542.pdf 19 16 separator 0.98486423 ¶ 1695 1697 W2079251542.pdf 19 17 paratext 0.6332586 P49 1697 1701 W2079251542.pdf 19 18 separator 0.94131386 ¶ 1701 1703 W2079251542.pdf 19 19 title 0.8866459 "Pulmonary permeability index predicts progression to acute lung injury in patients with increased risk" 1703 1808 W2079251542.pdf 19 20 separator 0.9006913 ¶ 1808 1810 W2079251542.pdf 19 21 bibliography 0.8368651 "CR Phillips, K Bacon, J Pinney, A Nielsen, JL LeTourneau OHSU, Portland, OR, USA Critical Care 2009, 13(Suppl 1): P" 1810 1930 W2079251542.pdf 19 22 paratext 0.52054656 49 1930 1932 W2079251542.pdf 19 23 bibliography 0.5873496 (doi: 1932 1938 W2079251542.pdf 19 24 paratext 0.6302866 10.1186/cc7213) 1938 1954 W2079251542.pdf 19 25 separator 0.9955903 ¶ 1954 1956 W2079251542.pdf 19 26 title 0.7480678 Introduction 1956 1969 W2079251542.pdf 19 27 text 0.99403995 "Early identification of progression to acute lung injury (ALI) in patients at risk may change therapy and potentially improve outcome. Central to the pathogenesis of ALI is pulmonary micro- vascular injury and increased permeability resulting in pulmonary edema. We proposed that the pulmonary vascular permeability index (PVPI) (extravascular lung water (EVLW) (ml) / pulmonary blood volume (PBV) (ml)) reflects the severity of this injury and predicts progression to ALI in patients at risk." 1969 2477 W2079251542.pdf 19 28 separator 0.98897374 ¶ 2477 2479 W2079251542.pdf 19 29 title 0.57664716 Methods 2479 2487 W2079251542.pdf 19 30 text 0.99811774 "The PVPI was measured prospectively in 27 patients who either were at increased risk to develop ALI ( n= 17) or who had ALI on presentation ( n= 10) for the first 5 days after admission to the ICU." 2487 2691 W2079251542.pdf 19 31 separator 0.9831293 ¶ 2691 2693 W2079251542.pdf 19 32 text 0.992095 "Results Ten out of 17 patients at risk for ALI progressed to it. The mean (± SEM) PVPI on day 1 was lower in patients who did not develop ALI vs. those that did (1.4 ± 0.1 vs. 2.6 ± 0.4, P= 0.01) in the 17 patients who did not have ALI on presentation (Figure 1). There was no difference in PVPI for those that developed ALI vs. those that had it on presentation (2.6 ± 0.4 vs. 2.7 ± 0.3, P= 0.5). A cutoff PVPI value of 1.9 or less discriminated those that would not develop ALI from those who did or who had it on presentation with a sensitivity and specificity of 100% and 85%, respectively (Figure 2).Conclusions Increased PVPI is a feature of early ALI and predicts progression to ALI in patients at increased risk. Early identification of patients with elevated PVPI and who are at risk to develop ALI may lead to consideration of early initiation of lung protective ventilator strategies." 2693 3615 W2079251542.pdf 19 33 separator 0.99501586 ¶ 3615 3617 W2079251542.pdf 19 34 title 0.9710951 P50 3617 3621 W2079251542.pdf 19 35 separator 0.9543281 ¶ 3621 3623 W2079251542.pdf 19 36 title 0.98332834 "Pulmonary electrical impedance tomography changes in a model of hemorrhagic shock with endotoxemia and resuscitation" 3623 3744 W2079251542.pdf 19 37 separator 0.98974144 ¶ 3744 3746 W2079251542.pdf 19 38 contact 0.7266791 J Noel-Morgan1, D Fantoni2, D Otsuki1, JO Auler Jr1 3746 3798 W2079251542.pdf 19 39 separator 0.6212716 ¶ 3798 3800 W2079251542.pdf 19 40 contact 0.983532 "1Faculdade de Medicina da Universidade de São Paulo, Brazil; 2Faculdade de Medicina Veterinaria e Zootecnia da Universidade de São Paulo, Brazil" 3800 3949 W2079251542.pdf 19 41 separator 0.7435204 ¶ 3949 3951 W2079251542.pdf 19 42 paratext 0.6403324 Critical Care 2009, 13(Suppl 1): P50 (doi: 10.1186/cc7214) 3951 4010 W2079251542.pdf 19 43 separator 0.9956727 ¶ 4010 4012 W2079251542.pdf 19 44 text 0.99638444 "Introduction Electrical impedance tomography (EIT) is a promising bedside device with the potential to assess changes in regional ventilation and lung blood flow [1]. The purpose of our study was to monitor lung images and changes in impedance by EIT in a model of hemorrhagic shock with endotoxemia followed by fluid resuscitation." 4012 4355 W2079251542.pdf 19 45 separator 0.9540488 ¶ 4355 4357 W2079251542.pdf 19 46 text 0.9936183 "Methods Twelve anesthetized, mechanically ventilated, supine pigs were submitted to hemorrhagic shock (50% blood volume) and endotoxin infusion. Animals were randomly allocated to control" 4357 4549 W2079251542.pdf 19 47 paratext 0.94707304 Critical Care March 2009 Vol 13 Suppl 1 29th International Symposium on Intensive Care and Emergency Medicine 4549 4661 W2079251542.pdf 19 48 separator 0.99389946 ¶ 4661 4663 W2079251542.pdf 19 49 caption 0.972532 Figure 1 (abstract P49) 4663 4687 W2079251542.pdf 19 50 separator 0.8972852 ¶ 4687 4689 W2079251542.pdf 19 51 caption 0.9762117 Figure 2 (abstract P49) 4689 4713 W2079251542.pdf 19 52 separator 0.99048764 ¶ 4713 4715 W2079251542.pdf 19 0 paratext 0.9287284 "Citation: Matsuzawa, A.; Shiroki, Y. Mothers’ Experiences of Care Coordination for Children with Disabilities: A Qualitative Study. Children 2022 ,9, 835. https:// doi.org/10.3390/children9060835" 0 205 W4281765110.pdf 0 1 separator 0.6338684 ¶ 205 207 W4281765110.pdf 0 2 paratext 0.91635334 "Academic Editor: Jane D. Champion Received: 12 April 2022 Accepted: 1 June 2022 Published: 4 June 2022" 207 316 W4281765110.pdf 0 3 separator 0.82290626 ¶ 316 318 W4281765110.pdf 0 4 paratext 0.55543387 "Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims" 318 394 W4281765110.pdf 0 5 text 0.39653286 in 394 398 W4281765110.pdf 0 6 paratext 0.433016 ¶ published maps and institutional affil- 398 438 W4281765110.pdf 0 7 text 0.43256998 ¶ 438 441 W4281765110.pdf 0 8 paratext 0.46403813 iations. 441 449 W4281765110.pdf 0 9 separator 0.8441283 ¶ 449 451 W4281765110.pdf 0 10 paratext 0.9224271 "Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)." 451 718 W4281765110.pdf 0 11 separator 0.91729903 ¶ 718 720 W4281765110.pdf 0 12 paratext 0.70851517 children 720 729 W4281765110.pdf 0 13 separator 0.7956339 ¶ 729 731 W4281765110.pdf 0 14 title 0.89055306 Article 731 739 W4281765110.pdf 0 15 separator 0.79167163 ¶ 739 741 W4281765110.pdf 0 16 title 0.9841841 "Mothers’ Experiences of Care Coordination for Children with Disabilities: A Qualitative Study" 741 837 W4281765110.pdf 0 17 separator 0.99115866 ¶ 837 839 W4281765110.pdf 0 18 contact 0.988961 Akemi Matsuzawa1,* and Yuko Shiroki2 839 876 W4281765110.pdf 0 19 separator 0.53057903 ¶ 876 878 W4281765110.pdf 0 20 contact 0.9927642 "1Department of Comprehensive Development Nursing, Graduate School of Health Sciences and Faculty of Medicine, Hokkaido University, Sapporo 060-0812, Hokkaido, Japan 2School of Nursing, Ibaraki Christian University, Hitachi 319-1295, Ibaraki, Japan; shiroki@icc.ac.jp *Correspondence: akemim_222@yahoo.co.jp" 878 1191 W4281765110.pdf 0 21 separator 0.99412537 ¶ 1191 1193 W4281765110.pdf 0 22 text 0.9986587 "Abstract: Few studies have investigated the care coordination for children with disabilities and their families in Japan. Care coordination enhances the quality of care for these children and their families. This study explores mothers’ experiences of coordinated care provided to their children with disabilities and their families. We used a qualitative descriptive approach, conducting semi-structured interviews with 11 Japanese mothers/primary caregivers of children with disabilities to describe their experiences. Four main themes were identified: shared decision-making with key workers, receiving an assessment of the entire family, timely access to coordinated health care services, and a reduced psychological burden and empowerment of mothers. Our findings suggest that care coordination has multiple beneficial effects on children with disabilities and their families, including improving the outcomes. Further research should examine how high-quality care coordination can be provided for such children and their families." 1193 2247 W4281765110.pdf 0 23 separator 0.9891081 ¶ 2247 2249 W4281765110.pdf 0 24 text 0.5495696 Keywords: children with disability; mother; primary caregiver; family; care coordination 2249 2338 W4281765110.pdf 0 25 separator 0.9972849 ¶ 2338 2340 W4281765110.pdf 0 26 title 0.9862972 1. Introduction 2340 2356 W4281765110.pdf 0 27 separator 0.99554175 ¶ 2356 2358 W4281765110.pdf 0 28 text 0.9993423 "Care coordination is important for children with disabilities [ 1] and is a cornerstone of family-centered care [ 2,3]. In general, compared to typically developing children, children with disabilities face an increased risk of developing chronic physical, developmental, behavioral, or emotional conditions, and require additional health care and related ser- vices [4]. Therefore, as previous studies have reiterated, coordinated care and services are essential to ensure quality care for these children and their families [5]." 2358 2898 W4281765110.pdf 0 29 separator 0.95802116 ¶ 2898 2900 W4281765110.pdf 0 30 text 0.99957395 "In Japan, the need for coordinated care for children with disabilities is increasing as the number of children with disabilities is rising despite the declining birth rate. As of 2016, approximately 68,000 children suffer from physical disabilities and 214,000 children from intellectual disabilities [ 6]. The number of children receiving medical care is rapidly in- creasing too. The Ministry of Health, Labour and Welfare (MHLW) reported that 9403 were children dependent on medical technology in 2005 [ 7]. However, this number increased to 17,078 by 2015. Additionally, the number of ventilator-dependent children also increased from 264 in 2005 to over 3064 in 2015. Moreover, the health care system for children with disabilities in Japan is inadequate in both quality and quantity, which makes it difficult for all children with disabilities and their families to receive the high-quality services they need [8]." 2900 3840 W4281765110.pdf 0 31 separator 0.99759936 ¶ 3840 3842 W4281765110.pdf 0 32 title 0.9865564 1.1. Background 3842 3858 W4281765110.pdf 0 33 separator 0.9947476 ¶ 3858 3860 W4281765110.pdf 0 34 text 0.968186 "The effect of care coordination for families of children with special health care needs (CSHCN) is well-documented and includes improvements in multiple outcomes, such as an increase in receiving family-centered care and experience of partnerships with profes- sionals [ 9]. Additionally, care coordination for CSHCN meets almost all service-related" 3860 4216 W4281765110.pdf 0 35 separator 0.650056 ¶ 4216 4218 W4281765110.pdf 0 36 paratext 0.9711176 Children 2022 ,9, 835. https://doi.org/10.3390/children9060835 https://www.mdpi.com/journal/children 4218 4319 W4281765110.pdf 0 0 title 0.8258961 FAILURE OF THE WELL-ROUNDED RETRACT 0 35 W4389432407.pdf 2 1 paratext 0.673313 433 35 39 W4389432407.pdf 2 2 separator 0.989756 ¶ 39 41 W4389432407.pdf 2 3 text 0.9852137 "graphs whose systoles fill in that sense forms a spine and if so, what its dimension is." 41 131 W4389432407.pdf 2 4 separator 0.77823687 ¶ 131 133 W4389432407.pdf 2 5 text 0.9995226 "One may wonder if there is a spine of the minimal dimension 2 n−3c o n t a i n e d inV/prime n. However, it seems difficult to push the deformation retraction defined in the proof of Theorem 1.3 much further. One can continue until there is a systolepassing through any pair of edges that are adjacent to a vertex of degree 3 by folding these edges gradually otherwise, but the proof of Theorem 1.4 implies that the dimension of the resulting set is still too large in general." 133 618 W4389432407.pdf 2 6 separator 0.9966316 ¶ 618 620 W4389432407.pdf 2 7 title 0.99195683 2.Outer space 620 634 W4389432407.pdf 2 8 separator 0.99626994 ¶ 634 636 W4389432407.pdf 2 9 text 0.99962246 "We start by proving the negative results regarding Outer space. The proof of both Theorem 1.1 and Theorem 1.4 is based on the same family of graphs that havea large automorphism group and few systoles that cover the whole graph. Thesegraphs were used in [FB20] to construct hyperbolic surfaces with similar properties." 636 957 W4389432407.pdf 2 10 separator 0.92759717 ¶ 957 959 W4389432407.pdf 2 11 text 0.9995791 "Given integers p,q≥2, a map of type {p,q}is a connected graph of constant valence (degree) qembedded in an oriented surface such that each complementary region (whose closure is called a face) is a topological disk whose boundary consists ofpedges. This can also be phrased in terms of a ribbon structure on the graph. A flagis a triple ( v,e,f)w h e r evis a vertex, eis an edge, fis a face, and v⊂e⊂f.A mapis flag-transitive ifforanytwoflagsthereisahomeomorphismoftheunderlying surface which sends the map to itself and the first flag to the second. For now weconsider our maps as combinatorial graphs where each edge has length 1. The girth of a combinatorial graph is the same as its systole, namely, the minimal length of a cycle that is not contractible." 959 1731 W4389432407.pdf 2 12 separator 0.9055495 ¶ 1731 1733 W4389432407.pdf 2 13 text 0.9990895 "We will require a small variation of a result of Evans [Eva79, Theorem 11] about the existence of flag-transitive maps of large girth. The difference here is that we want to make sure that only the obvious cycles have length equal to the girth." 1733 1980 W4389432407.pdf 2 14 separator 0.9946128 ¶ 1980 1982 W4389432407.pdf 2 15 text 0.91906655 "Lemma 2.1. For any q≥3andp≥7, there exists a finite flag-transitive map M of type{p,q}and girth psuch that the only non-trivial cycles of length pinMare the face boundaries." 1982 2158 W4389432407.pdf 2 16 separator 0.95379037 ¶ 2158 2160 W4389432407.pdf 2 17 text 0.9978714 "Proof.There is an infinite flag-transitive map M p,qof type{p,q}embedded in the hyperbolic plane H2coming from the tiling by regular p-gons with interior angles 2π/q. The automorphisms of Mp,qare realized by a finitely-generated discrete groupGof isometries of the hyperbolic plane. By Mal’cev’s theorem [Mal65], Gis residually finite, so there is a sequence of normal subgroups Gk/triangleleftGof finite index such that/intersectiontextGk={id}. This implies that Gkis eventually torsion-free and the closed hyperbolic surfaces Sk=H2/Gkhave injectivity radius going to infinity as k→∞.I fkis large enough, then the projection MkofMp,qtoSkhas type {p,q} because the map H2→Skis a covering map. Furthermore, Mkis finite since Mp,q/Gis a half-edge and Gkhas finite index in G.L a s t l y , Mkis flag-transitive via the quotient group G/Gkacting on Sk." 2160 3022 W4389432407.pdf 2 18 separator 0.93263733 ¶ 3022 3024 W4389432407.pdf 2 19 text 0.9995172 "Since the face boundaries in Mkhave combinatorial length p,t h eg i r t ho f Mkis at mostp. Since the injectivity radius of Sktends to infinity, any cycle in Mkwhich is not contractible in Skbecomes arbitrarily long (with respect to the hyperbolic metric and therefore also in terms of its number of edges) as ktends to infinity." 3024 3358 W4389432407.pdf 2 20 separator 0.6942023 ¶ 3358 3360 W4389432407.pdf 2 21 text 0.9993405 "In particular, a cycle in Mkthat is not contractible in Skhas combinatorial length strictly larger than pifkis large enough. It is also true that any cycle in Mkwhich" 3360 3529 W4389432407.pdf 2 0 paratext 0.9875977 IJAAR Vol.10 No.1 ISSN – 2347 -7075 0 46 W4309982043.pdf 7 1 separator 0.7847405 ¶ ¶ 48 54 W4309982043.pdf 7 2 contact 0.78760916 Shambhu Raj Upadhyay & Dr. Bhaw N ath Pandey 54 100 W4309982043.pdf 7 3 separator 0.9360626 ¶ 102 104 W4309982043.pdf 7 4 text 0.96632475 "543 broadcasting educational recordings to get access for students where internet access is little or no access. Some other online modes like web conferencing and online meeting tools like zoom, Google meet, WebEx , Telegram , and so on provided a meeting platform for online e -learning and real-time live streaming." 104 445 W4309982043.pdf 7 5 separator 0.9434549 ¶ ¶ 448 454 W4309982043.pdf 7 6 text 0.6455577 Conclusion: 454 466 W4309982043.pdf 7 7 separator 0.79213977 ¶ 468 470 W4309982043.pdf 7 8 text 0.99909073 "The sudden outbreak of the coronavirus has forced us to incorporate and implement revolutionary change not only in its traditional nature of service but to adopt new technology and train staff to work according to pace with time. The internet and web-based technologies strengthen the teaching -learning environment and bridge the digital divide through innovative educational applications . The use of computers was not a new concept during the pandemic in the library . The library was user-friendly for a long time, but the present crisis acted as a catalyst to strengthen the basic infrastructure. The effect can be seen in digital libraries as fulfilling the laws of library science by adding e-learning resources in collections e very reader h is / her Books." 470 1308 W4309982043.pdf 7 9 separator 0.9493191 ¶ ¶ 1310 1316 W4309982043.pdf 7 10 text 0.9905655 "Suggestions: The success of online learning depen ds upon the ability and capability of the person to train the right people to develop the right skills, knowledge, and the right time to implement it. The success of e -learning depends on devotion to implementing modern technology in the traditional classr oom. Bixler and Spats (2000) have identified seven parameters affecting the successful implementation of e-learning: institutional support , course development , teaching and learning , course structure , student support , faculty support , and evaluation and assessment . Support from the institution and dedication from the staff is the key point of the success of e -learning." 1316 2057 W4309982043.pdf 7 11 separator 0.99614143 ¶ 2060 2062 W4309982043.pdf 7 12 title 0.6771155 Reference s: 2062 2075 W4309982043.pdf 7 13 separator 0.98903364 ¶ 2076 2078 W4309982043.pdf 7 14 bibliography 0.9903397 "1. Abbas, A., & Faiz, A. (2013). Usefulness of digital and traditional libraries in higher education. Internat ional Journal of Services, Technology and Management , 19(1–3), 149 –161. https://doi.org/10.1504/IJSTM.201 3.054203" 2078 2326 W4309982043.pdf 7 15 separator 0.96836174 ¶ 2328 2330 W4309982043.pdf 7 16 bibliography 0.9914245 "2. Association of College and Research Libraries(2020). Pandemic resourcesfor academic libraries.https://accrl.libguides.com /pandemic/home" 2330 2481 W4309982043.pdf 7 17 separator 0.9058322 ¶ 2483 2485 W4309982043.pdf 7 18 bibliography 0.9921992 "3. Department of Higher Education | Government of India, Ministry of Education. (n.d.). Retrieved September10, 2020, from https://www.mhrd.gov.in/higher_e ducation" 2485 2663 W4309982043.pdf 7 19 separator 0.9591625 ¶ 2665 2667 W4309982043.pdf 7 20 bibliography 0.99181527 "4. Gaikwad, M. N. Use Of Social Networking Sites Among Undergraduate Students Of Arts And Commerce College, Madha, Dist. Solapur, Maharastra. Retrieved From: http://www.klibjlis.com/3.2. 3.pdf" 2667 2881 W4309982043.pdf 7 21 separator 0.9792612 ¶ 2884 2886 W4309982043.pdf 7 22 bibliography 0.98991925 "5. Shivakumar G.T., (2017). Impact of digital era on academic Libraries: it’s play with library " 2886 2991 W4309982043.pdf 7 23 separator 0.55250573 ¶ 2991 2992 W4309982043.pdf 7 24 bibliography 0.99617803 "6. Professionals. International Journal of Library & Information Science (IJLIS). 6(4)." 2992 3086 W4309982043.pdf 7 25 separator 0.5248204 ¶ 3088 3090 W4309982043.pdf 7 26 bibliography 0.99458295 "7. Retrieved from http://www.iaeme.com/IJLIS/issue s.asp?JType=IJLIS&VType=6&IT ype=4" 3090 3183 W4309982043.pdf 7 27 separator 0.96338034 ¶ 3185 3187 W4309982043.pdf 7 28 bibliography 0.9934442 "8. Velumani, K. V. (2013). An investigation into the impact of e - resources in modern Library and Information Centers. Retrieved from: http://hdl.handle.n et/10603/5 4204" 3187 3373 W4309982043.pdf 7 29 separator 0.9555626 ¶ 3375 3377 W4309982043.pdf 7 30 bibliography 0.9940519 "9. http://www.ala.org/tools/libraries - respond -covid -19-survey ." 3377 3447 W4309982043.pdf 7 31 separator 0.7858854 "¶ ¶" 3448 3458 W4309982043.pdf 7 0 paratext 0.9898217 Int. J. Mol. Sci. 2022 ,23, 5749 3 of 24 0 40 W4280521346.pdf 2 1 separator 0.9939302 ¶ 40 42 W4280521346.pdf 2 2 text 0.9993723 "applied GSH positively affects ET biosynthesis by modulating the transcriptional and post-transcriptional regulations of the ACS and ACO enzymes [ 49]. GSH depletion resulted in decreased lateral root density and root meristem malfunction [ 53]. Genome-wide tran- script profiling analysis uncovered that numerous redox-related genes including GPXLs are implicated in the interaction between the redox and hormonal signalling [ 53]. The differences we have found earlier in the phenotype and salt stress response of the Atgpxl5-1 mutant and AtGPXL5 -overexpressing plants also indicated a complex interaction among the membrane-localised GPXL5, GSH redox potential and plant growth [ 7,18]. The growth of the Atgpxl5 mutant but not the AtGPXL5 -overexpressing (OX-AtGPXL5) plants was delayed in the standard growth condition [18]." 42 890 W4280521346.pdf 2 3 separator 0.98165953 ¶ 890 892 W4280521346.pdf 2 4 text 0.999432 "In this paper, we investigated the effect of ET on the development of the Atgpxl5 and OX-AtGPXL5 seedlings, treating them with the ET-precursor ACC. It was observed that a lower number of lateral roots developed on 2-week-old mutant plantlets as compared to their wild type and OX-AtGPXL5 counterparts. Furthermore, the dark-grown Atgpxl5 mutants exhibited an altered hypocotyl hook development. Thus, we aimed to investigate the effect of AtGPXL5 on ET biosynthesis and/or signalling. The ET evolution and the expression of selected ET-related genes, several oxidative stress parameters and antioxidant mechanisms were analysed in 6-week-old hydroponically grown ACC-treated plants." 892 1590 W4280521346.pdf 2 5 separator 0.96932435 ¶ 1590 1592 W4280521346.pdf 2 6 text 0.9994107 "Our results indicated that ACC differently changed the GSH level, the redox potential, the activities of glutathione- and thioredoxin peroxidases and that of some other ROS- processing enzymes in the Atgpxl5 mutant and AtGPXL5-overexpressor lines than in the wild type, but several physiological traits, among them the skotomorphogenesis, ethylene evolution and the redox potential of OX-AtGPXL5, were similar to that of the wild-type seedlings." 1592 2048 W4280521346.pdf 2 7 separator 0.9963819 ¶ 2048 2050 W4280521346.pdf 2 8 title 0.9902222 2. Results 2050 2061 W4280521346.pdf 2 9 separator 0.9937202 ¶ 2061 2063 W4280521346.pdf 2 10 title 0.9910806 2.1. AtGPXL5 Regulates Hypocotyl Hook Development and Seedling Growth 2063 2133 W4280521346.pdf 2 11 separator 0.99492043 ¶ 2133 2135 W4280521346.pdf 2 12 text 0.9995857 "The growth parameters of in vitro grown 2-week-old seedlings of Col-0 wild type, Atgpxl5-1 mutant and OX-AtGPXL5-overexpressor Arabidopsis lines were compared. It was revealed that the light-grown seedlings possessed a similar phenotype except with shorter primary roots and a lower number of lateral roots of the Atgpxl5-1 mutant than the wild type or the OX-AtGPXL5 plants (Table 1)." 2135 2529 W4280521346.pdf 2 13 separator 0.99659395 ¶ 2529 2531 W4280521346.pdf 2 14 caption 0.6034205 Table 1. The length of primary root and the number of lateral roots of two-week-old Arabidopsis 2531 2627 W4280521346.pdf 2 15 table 0.36987886 ¶ 2627 2629 W4280521346.pdf 2 16 caption 0.61674464 wild type (Col-0) and glutathione peroxidase-like 5 mutant ( Atgpxl5-1 ) and overexpressing line 2629 2726 W4280521346.pdf 2 17 table 0.635264 ¶ 2726 2728 W4280521346.pdf 2 18 caption 0.64881074 (OX-AtGPXL5) plantlets grown in light after transferring 5-day-old seedlings onto1 2728 2811 W4280521346.pdf 2 19 table 0.5521433 ¶ 2811 2813 W4280521346.pdf 2 20 caption 0.7236228 2MS media. 2813 2824 W4280521346.pdf 2 21 separator 0.55017227 ¶ 2824 2826 W4280521346.pdf 2 22 caption 0.95479167 "MeanSD,n= 15. Data were analysed using one-way ANOVA followed by Duncan’s test. Different letters represent data considered statistically significant at p0.05." 2826 2989 W4280521346.pdf 2 23 separator 0.9838176 ¶ 2989 2991 W4280521346.pdf 2 24 table 0.99169093 "Growth Parameters Col-0 Atgpxl5 OX-AtGPXL5 Root length (cm) 4.81 0.17 a 3.81 0.14 b 4.68 0.15 a Number of lateral roots 3.46 0.24 a 2.60 0.28 b 3.50 0.26 a" 2991 3157 W4280521346.pdf 2 25 separator 0.9843687 ¶ 3157 3159 W4280521346.pdf 2 26 text 0.99898803 "The dark-grown Atgpxl5 mutants were smaller; furthermore, they had an altered hypocotyl hook development compared to other genotypes (Figure 1). The different skoto- morphogenesis of the Atgpxl5 mutants and OX-AtGPXL5 seedlings raised the possibility of the crosstalk between the AtGPXL5 protein and the ET response." 3159 3482 W4280521346.pdf 2 0 title 0.9931268 1. The Basic Connotation of Rule of Law Thinking Among College Students in the New Era 0 86 W4393230566.pdf 1 1 separator 0.996619 ¶ 87 89 W4393230566.pdf 1 2 title 0.9907913 1.1 The Connotation of Rule of Law Thinking 89 133 W4393230566.pdf 1 3 separator 0.994433 ¶ 134 136 W4393230566.pdf 1 4 text 0.99967694 "Rule of law thinking is a deep -level thinking mode based on the concept of the rule of law, which requires people to follow legal principles in decision -making and actions, emphasizing legitimacy, justice, and fairness. Compared with legal thinking, rule of law thinking not only focuses on the professionalism and technicality of law but also emphasizes the universal values and social effects of the rule of law. R ule of law thinking emphasizes putting people first, regarding law as a tool to maintain social order and safeguard people's rights and interests, rather than merely a technical means. This way of thinking aims to cultivate people's faith in the rule of la w, making the rule of law the daily behavioral norms of people and promoting the legalization process of society. In contrast, legal thinking focuses more on the interpretation and application of legal provisions and is a professional occupational thinking . Rule of law thinking is a way of integrating rule of law principles into daily decision -making and behaviors, requiring people to always uphold the spirit of the rule of law in thinking and actions to ensure the legality and justice of behaviors. Legal t hinking, on the other hand, focuses more on legal professionals' interpretation and application of legal provisions and cases[1]. Although rule of law thinking and legal thinking overlap, they have different focuses and together constitute an important par t of the rule of law culture." 136 1656 W4393230566.pdf 1 5 separator 0.9971604 ¶ 1658 1660 W4393230566.pdf 1 6 title 0.9938042 1.2 Key Points in Cultivating Rule of Law Thinking Among College Students 1660 1734 W4393230566.pdf 1 7 separator 0.9960073 ¶ 1735 1737 W4393230566.pdf 1 8 title 0.990248 1.2.1 Cultivating the Value Pursuit of Constitutional Supremacy 1737 1801 W4393230566.pdf 1 9 separator 0.99434257 ¶ 1803 1805 W4393230566.pdf 1 10 text 0.9986851 """To adhere to governing the country according to law, we must first adhere to governing the country according to the constitution, and to govern according to law, we must first adhere to governing according to the constitution."" For college students, the cultivation of rule of law thinking should start with a profound understanding of the fun damental status of the constitution." 1805 2196 W4393230566.pdf 1 11 separator 0.89774585 ¶ 2197 2199 W4393230566.pdf 1 12 text 0.9993429 "The existence of the constitution is a prerequisite for the rule of law, and its effective implementation is the cornerstone of building a rule of law country. Therefore, college students need to comprehensively underst and and grasp the basic rules and values of the constitution, clarify the goals and directions of national development, and the basic principles and measures formulated to achieve the well -being of the people." 2199 2642 W4393230566.pdf 1 13 separator 0.81753385 ¶ 2644 2646 W4393230566.pdf 1 14 text 0.9996453 "In addition, college students should actively embrace the authority of the constitution and establish a firm belief in the constitution. The vitality of law lies in being believed, and this is especially true for the constitution. Upholding the authority of the constitution means defending the common will of the country and the people. College students should deeply understand that defending the dignity of the constitution is defending the dignity of the country and the people." 2646 3141 W4393230566.pdf 1 15 separator 0.7543955 ¶ 3142 3144 W4393230566.pdf 1 16 text 0.99945265 "Only by truly acknowledging and believing in the constitution from the bott om of their hearts will college students consciously follow the spirit of the constitution, thereby demonstrating reverence and obedience to the constitution." 3144 3385 W4393230566.pdf 1 17 separator 0.9494726 ¶ 3387 3389 W4393230566.pdf 1 18 text 0.9996847 "In the process of cultivating rule of law thinking, college students should also use constitutionality as the criterion for behavior. This means that when observing social phenomena, analyzing conflicts and disputes, and resolving legal issues, they should use the constitution as a guideline and standard. This thinking guided by the constitution is a concrete manifestation and sublimation of the belief in the rule of law, as well as the organic unity of worldview and methodology. Therefore, college students need to learn to independently judge in accordance with the values, basic provisions, and proced ures of the constitution. This is the basic requirement for cultivating rule of law thinking among college students and is also the necessary path for them to" 3389 4179 W4393230566.pdf 1 19 separator 0.73131406 ¶ 4180 4182 W4393230566.pdf 1 20 paratext 0.87996113 10 4182 4185 W4393230566.pdf 1 0 text 0.9992038 diseases were responsible for more than half of all deaths [6]. 0 63 W2136368101.pdf 1 1 separator 0.9877173 ¶ 63 65 W2136368101.pdf 1 2 text 0.9995314 "Portugal is characterized by a very higher contribution of cere- brovascular disease to mortality relative to coronary heart dis-ease [1] and long-standing higher systolic blood pressure, as compared to most other European countries [7]. The types of cancers that cause more deaths in Portugal are lung and stom-ach among men and breast among women [4]. The relatively early stage of Portugal in the smoking epidemic results in an expected increase in the smoking-related burden of diseaseand deaths, particularly among women [8,9]." 65 608 W2136368101.pdf 1 3 separator 0.97767067 ¶ 608 610 W2136368101.pdf 1 4 text 0.99652785 "We aimed to describe time trends in the absolute number of deaths, death rates and YLL from CVD and cancer in thePortuguese population, during the period 1980 –2010, and to quantify the contribution of the variation in the popula- tion ’s size and age structure, and age-independent “risk”of death by cardiovascular or oncological causes to the change in the corresponding number of deaths." 610 1011 W2136368101.pdf 1 5 separator 0.99685466 ¶ 1011 1013 W2136368101.pdf 1 6 title 0.9899355 Methods 1013 1021 W2136368101.pdf 1 7 separator 0.9753468 ¶ 1021 1023 W2136368101.pdf 1 8 title 0.98149085 Sources of data 1023 1039 W2136368101.pdf 1 9 separator 0.9906671 ¶ 1039 1041 W2136368101.pdf 1 10 text 0.9995258 "The number of deaths from all CVD [International Clas-sification of Diseases 10th revision (ICD 10): I00-I99; 9th revision (ICD 9): 390 –459] and all malignant neoplasms , hereafter just referred as cancer (ICD 10: C00-C99; ICD 9: 140 –239), as well as the estimates of the population at risk in each year, were obtained from official statistics[10,11]." 1041 1403 W2136368101.pdf 1 11 separator 0.7179415 ¶ 1403 1405 W2136368101.pdf 1 12 text 0.99869114 "All data were obtained from 1980 to 2010 for each sex in age groups (<1, 1 –4, 5-year age groups up to 80 –84 and≥85 years)." 1405 1534 W2136368101.pdf 1 13 separator 0.9970234 ¶ 1534 1536 W2136368101.pdf 1 14 title 0.9906098 Trends in mortality rates and years of life lost 1536 1585 W2136368101.pdf 1 15 separator 0.99222136 ¶ 1585 1587 W2136368101.pdf 1 16 text 0.99957407 "Standardized mortality rates were computed by the dir- ect method using the European standard population as reference [12]. We performed a joinpoint regression ana-lysis, using Joinpoint Wversion 3.4 from the Surveillance Research Program of the US National Cancer Institute [13], to calculate the annual variation in mortality and toidentify points of significant change in the log-linear slope of the trend (joinpoints) [14]. The analysis starts with the minimum number of joinpoints (no joinpointscorresponds to a straight line), and tests whether one or more joinpoints significantly improve model fit. The minimum number of observations from a joinpoint tothe earliest or the latest years and between two join- points was set to 5. We present the results of best fitting models for the trends in men and women. The estimatedannual percent change (APC) in mortality for each period was calculated assuming a Poisson distribution and taking the calendar year as the independent variable." 1587 2604 W2136368101.pdf 1 17 separator 0.9832133 ¶ 2604 2606 W2136368101.pdf 1 18 text 0.99965197 "The analyses of the trends in the mortality rates and numbers of deaths were performed for all ages and by age groups (0 –14, 15 –34, 35 –54, 55 –74 and ≥75 years).The YLL due to premature mortality for each cause (CVD and cancer), gender and age group were com- puted using the Global Burden of Disease method [15]by multiplying the number of deaths at each age by the life expectancy at the age at which death occurs. We considered the recommended standard life expectancy atbirth of 80 years for men and 82.5 for women. The aver- age age at death was set to the mid-point of each five- year age group, apart from the infant deaths (where it isassumed to be 0.1 years in low mortality countries), the 1–4 year age group (assumed to be 2.6 years) and the oldest group (assumed to be 87.5 years) [15]. We applieda 3% time discount rate to assign less weight to the YLL corresponding to the periods more distant to the mo- ment of death than to those referring to the first yearsafter death, an age-weighting parameter to weigh YLL in very young and old ages less than other ages (Global Burden of Disease standard value is 0.04) and an age-weighting correction constant so that the introduction of age-weights did not alter the total number of YLL (Global Burden of Disease standard value is 0.1658) [15].The total YLL for each cause and gender was obtained by adding the YLL of all age groups." 2606 4035 W2136368101.pdf 1 19 separator 0.9966917 ¶ 4035 4037 W2136368101.pdf 1 20 title 0.9930401 "Contribution of changes in demographics and age-independent “risk ”" 4037 4107 W2136368101.pdf 1 21 separator 0.99293804 ¶ 4107 4109 W2136368101.pdf 1 22 text 0.9996446 "We used the tool RiskDiff, a web-based application from the Catalan Institute of Oncology to assess the specific contribution of demographic changes (due to changes in population size and in population age structure) and thevariation in the age-independent “risk ”of dying from the disease to the observed trends in the number of deaths [16]. This analysis was performed for the periods withconstant log-linear trend identified in the joinpoint ana- lysis. RiskDiff outputs the results over an entire time period. To allow comparisons among intervals of differ-ent length, we estimated annual effects assuming geo- metric change over time [17]." 4109 4770 W2136368101.pdf 1 23 separator 0.99701065 ¶ 4770 4772 W2136368101.pdf 1 24 title 0.9834176 Results 4772 4780 W2136368101.pdf 1 25 separator 0.99060905 ¶ 4780 4782 W2136368101.pdf 1 26 title 0.9691903 Trends in mortality rates and years of life lost 4782 4831 W2136368101.pdf 1 27 separator 0.97931117 ¶ 4831 4833 W2136368101.pdf 1 28 text 0.9978746 "Among men, the age-adjusted mortality from CVD decreased between 1980 and 2010 (Figure 1 and Table 1). The decrease was more pronounced after 1993, with an APC of −4% per year versus −1.5% per year between 1980 and 1993. The age-adjusted mortality rate from cancers increased 0.9% per year between 1980 and 1997, then declined slightly, 0.7% per year, until 2006 andincreased 1.5% per year thereafter, in men. Among women, the pattern of the age-adjusted mortality from CVD was similar to that of men, decreasing between1980 and 2010, more pronouncedly after 1996, reaching an APC of −4.6% per year. The mortality rate from can- cer increased from 1980 to 1990, then decreased slightly" 4833 5539 W2136368101.pdf 1 29 paratext 0.9893901 Pereira et al. BMC Public Health 2012, 12:1126 Page 2 of 8 5539 5597 W2136368101.pdf 1 30 separator 0.56495434 5597 5598 W2136368101.pdf 1 31 paratext 0.95575464 ¶ http://www.biomedcentral.com/1471-2458/12/1126 5598 5646 W2136368101.pdf 1 0 paratext 0.99050874 J. Imaging 2023 ,9, 264 3 of 16 0 31 W4389082644.pdf 2 1 separator 0.9941907 ¶ 31 33 W4389082644.pdf 2 2 title 0.95100653 "Table 1. Data acquisition protocols used for dose optimization in default clinical brain protocols of the Neusoft NeuViz 128 CT scanner." 33 172 W4389082644.pdf 2 3 separator 0.9858872 ¶ 172 174 W4389082644.pdf 2 4 table 0.989668 "Parameters Default (Optimized Protocol) kVp 120 (80, 100, 140) mAs 300 (100, 200, 400) Rotation time 1.0 s Pitch 0.5 Slice thickness 5 mm SNR level 1.0 (0.3, 0.7, 1.3, 1.7) FOV 250 mm Kernel F20 IR 50% (20%, 30%, 40%, 60%) Clearview Matrix 512 12" 174 442 W4389082644.pdf 2 5 separator 0.99572873 ¶ 442 444 W4389082644.pdf 2 6 title 0.99436307 2.2. Data Acquisition and Image Quality Evaluation 444 495 W4389082644.pdf 2 7 separator 0.99497217 ¶ 495 497 W4389082644.pdf 2 8 text 0.9994309 "The Catphan 700 phantom was used to acquire the image by scanning according to three clinical routine scans for the brain. The AutoQA Plus v.1.8.7.0 software (QA Bench- mark, LLC, Ellicott City, MD, USA) was used to analyze image quality." 497 740 W4389082644.pdf 2 9 separator 0.9971398 ¶ 740 742 W4389082644.pdf 2 10 title 0.9937997 2.3. Catphan 700 Phantom 742 767 W4389082644.pdf 2 11 separator 0.99546826 ¶ 767 769 W4389082644.pdf 2 12 text 0.99947643 "A Catphan 700 phantom (The Phantom Laboratory Incorporated, Salem, NY, USA) was used to evaluate all image quality [ 31,32]. The phantom has a cylindrical shape and contains 6 modules, including CTP682 (geometry sensitometry and point source module), CTP714 (30-line pair high-resolution module), CTP515 (subslice and supra-slice low contrast), CTP721 (wave insert), CTP723 (bead blocks), and CTP712 (uniformity section). CT scans of the Catphan phantom were obtained using Neusoft NeuViz 128 (Neusoft Medical Systems, Shenyang, China) [ 33]. Quality control (QC) testing was performed annually for all CT scanners and the CT number was also calibrated." 769 1437 W4389082644.pdf 2 13 separator 0.9972172 ¶ 1437 1439 W4389082644.pdf 2 14 title 0.9940699 2.4. CT Number Accuracy and Linearity 1439 1477 W4389082644.pdf 2 15 separator 0.9956155 ¶ 1477 1479 W4389082644.pdf 2 16 text 0.99952465 "The module CTP682, containing different sensitometry targets, was used to perform CT number accuracy and linearity [ 34–36]. This module has sensitometry targets made from Teflon®, Bone 50%, Delrin®, Bone 20%, acrylic, Polystyrene and low-density polyethylene (LDPE), polymethylpentene (PMP), Lung foam #7112, and air, including a water container." 1479 1832 W4389082644.pdf 2 17 separator 0.7931892 ¶ 1832 1834 W4389082644.pdf 2 18 text 0.9945021 "In the circular region of interest (ROI), approximately 80% of each target size was selected and the measured mean CT number was recorded for each target. The mean CT number of each target was compared to the range of actual CT numbers from the specifications of the phantom. The linearity was also tested using Pearson’s correlation coefficient (r) between the measured CT number and each target’s linear attenuation coefficients ( ). The CT numbers’ accuracy should not exceed the tolerance limit from the recommendation range of the Catphan 700 phantom." 1834 2401 W4389082644.pdf 2 19 separator 0.99678344 ¶ 2401 2403 W4389082644.pdf 2 20 title 0.99435836 2.5. The High-Contrast Spatial Resolution and Modulation Transfer Function (MTF) 2403 2484 W4389082644.pdf 2 21 separator 0.99510473 ¶ 2484 2486 W4389082644.pdf 2 22 text 0.9996535 "High-contrast spatial resolution is the ability of a system to distinguish high-contrast objects from neighboring objects [ 37]. Two broad methods exist to analyze high-contrast spatial resolution by calculating the modulation transfer function (MTF) and objective analysis or resolution bar pattern assessment [ 37–39]. The spatial resolution is measured by calculating a small wire’s point spread function (PSF) with 0.05 mm tungsten (module CTP682). PSF generates line spread functions (LSFs) in both vertical and horizontal direc- tions. The MTF was calculated by taking the Fourier transform and shown in the value line pair/cm at 50%, 10%, and 2% of the MTF. The CTP714 high-resolution module with 1–30 line pair per cm gauges was used to evaluate high resolution. The tolerance levels of spatial resolution in the CT brain scan should exceed 5 lp/cm [ 36]. The expected values of MTF at 50%, 10%, and 2% exceeded 3, 5, and 7 cycles/cm, respectively [31,40,41]." 2486 3474 W4389082644.pdf 2 0 text 0.9992171 "through diagrammatic methods giving rise to the self- energy in terms of the Green function as in (8)] corresponds to the self-consistent mean-field approximation. This fact initself would render measurements from a quantum simu- lator containing two different species with corresponding interactions extremely useful." 0 326 W2984849590.pdf 2 1 separator 0.9742626 ¶ 326 328 W2984849590.pdf 2 2 text 0.9996603 "The question that is addressed in this paper, however, goes back to a basic, if for the moment, only theoretical question. In analogy to the questions posed in under- standing the Hubbard model and analogies in describingthe BEC-BCS crossover [4–8], we seek to understand what happens when the interaction coupling of a system of fermions interacting via an NJL-type Lagrangian is altered to such an extent that one moves into the weak -coupling regime of the theory: instead of fixing the NJL couplingstrength to its usual regularization dependent strong-coupling value, we treat it as a parameter and look for the solution of the gap equation as a function of this parameter. The difficulty in this lies in the fact that therelevant equations, which up to now have always beentreated as having real variables, must be regarded as complex. In what follows, we keep the QCD notation of the NJL model in order to check the validity of our resultson the real axis, but we abstract from this in thought inregarding the model as a two-component fermionic modelwith specific interaction." 328 1433 W2984849590.pdf 2 3 separator 0.98138523 ¶ 1433 1435 W2984849590.pdf 2 4 text 0.99962944 "We find a continuous quantum phase transition charac- terized by the development of a width for the dynamicallygenerated fermion mass onto the higher sheets of theRiemann surface associated with the gap equation. By an appropriate choice of the order parameter, we show that the power-law behavior of the phase transition does notdepend on our choice of regularization scheme —we have demonstrated this with the covariant, Pauli-Villars, and proper-time schemes. The value of the mass of the Goldstone particle is unaffected by this transition; however,the mass of the associated scalar meson also develops animaginary part." 1435 2072 W2984849590.pdf 2 5 separator 0.97636116 ¶ 2072 2074 W2984849590.pdf 2 6 text 0.9986452 "This paper is organized as follows: in Sec. II, we discuss the Riemann surface structure associated with the gapequation. In Sec. II A, we solve the gap equation for its spectrum in the covariant regularization scheme in both the strong- and weak-coupling regimes. We examine the stability of solutions against the choice of the regularizationscheme by studying the gap equation in the context of thePauli-Villars regularization scheme in Sec. II B, and we observe the same behavior of the order parameter in the vicinity of the phase transition point as it is obtained in the covariant regularization scheme. This is again verified inSec.II C, using the proper-time regularization scheme, and extended to include the effects of incorporating a constant electric field. Then, in Sec. III, we comment on the effects of the phase transition on the associated isovector pseu-doscalar and isoscalar scalar modes. We summarize andconclude in Sec. IV.II" 2074 3042 W2984849590.pdf 2 7 title 0.9473249 ". WEAK-COUPLING FERMIONIC MASS SOLUTIONS" 3042 3084 W2984849590.pdf 2 8 separator 0.9927776 ¶ 3084 3086 W2984849590.pdf 2 9 title 0.9882023 "A. Solutions of the gap equation in the covariant regularization scheme" 3086 3160 W2984849590.pdf 2 10 separator 0.99106264 ¶ 3160 3162 W2984849590.pdf 2 11 text 0.99084353 "Since the interaction terms in (2)are pointlike, the self- energy in (8)is constant and is thus identified as the dynamically generated mass, Σ1⁄4m /C3. Thus, the solution to the Green function equation containing Σ, Eq. (9),i s simple: in momentum space, it is SðpÞ1⁄4ðpþm/C3Þ= ðp2−m/C32Þ, which can be inserted into (8). The integral arising on the right-hand side of the gap equation Zd4p" 3162 3566 W2984849590.pdf 2 12 math 0.5015502 ¶ 3566 3568 W2984849590.pdf 2 13 text 0.6225594 ð2π 3568 3572 W2984849590.pdf 2 14 math 0.58596474 Þ4 3572 3574 W2984849590.pdf 2 15 text 0.503452 TrS 3574 3577 W2984849590.pdf 2 16 math 0.64251685 ðpÞð 3577 3581 W2984849590.pdf 2 17 text 0.93864495 "10Þ diverges and must be regulated. Oð3Þregularization leads to(5). In the covariant regularization scheme, which we will consider further here, the Euclidean four-momentum is restricted, p2 E1⁄4p2þp2 4≤Λ2, where p01⁄4ip4. Con- sequently, the gap equation takes the form" 3581 3862 W2984849590.pdf 2 18 separator 0.7443013 ¶ 3862 3864 W2984849590.pdf 2 19 math 0.91218245 "m/C31⁄41 2π2NcNfGΛ2m/C3/C20 1−m/C32 Λ2ln/C18 1þΛ2 m/C32/C19/C21 :ð11Þ" 3864 3944 W2984849590.pdf 2 20 separator 0.4915622 ¶ 3944 3946 W2984849590.pdf 2 21 text 0.98859453 "Canceling the m/C3on both sides, one has the well-known result [9]," 3946 4016 W2984849590.pdf 2 22 separator 0.6502456 ¶ 4016 4018 W2984849590.pdf 2 23 math 0.84861845 "2π2 NcNfGΛ21⁄41−z2ln/C20 1þ1 z2/C21 ; ð12Þ where z1⁄4m/C3=Λ" 4018 4084 W2984849590.pdf 2 24 text 0.9934252 ". In order to obtain a real solution for m/C3, the left-hand side of (12) should be less than one. [The right-hand side of (12), denoted as RðzÞ, has a global maximum of 1 at z1⁄40; see Fig. 1.] This leads to 2π2=ðNcNfÞ1⁄4π2=3 20 JBC events were included for JBC sub-analysis of either CD21lo(c–e) or all cells ( f–h) for c,fIgD+CD27+IgM+,d,gIgD−CD27+IgM+, and e,h IgD−CD27+IgG+subsets. Individual donors are plotted, and bars represent the mean ± SD. pvalues were determined using the Mann-Whitney U test, and significant values are indicated on each panel" 1965 2578 W3124293542.pdf 7 15 paratext 0.97599214 Young-Glazer et al. Arthritis Research & Therapy (2021) 23:33 Page 8 of 14 2578 2662 W3124293542.pdf 7 0 title 0.9896817 "Effect of L-cysteine deprivation on vesicular trafficking, cytoskeleton, and secretion" 0 88 W2090290137.pdf 12 1 separator 0.9931416 ¶ 88 90 W2090290137.pdf 12 2 text 0.99950284 "Response to changing envi ronmental conditions by eukaryotic cells also includes modulation of protein degradation, targeting, transport to specific organelles,and secretion. Amino acid deprivation has been shownto regulate vesicular trafficking, secretion, exocytosis,and autophagy [46]. L-Cysteine limitation also modu-lates several proteins associated with these processes in E. histolytica . For example, four genes encoding putative cysteine proteases (EHI_123950, EHI_121160, EHI_160330, EHI_182260) were down-regulated in atime-dependent manner during L-cysteine deprivation(Table 2; Additional file 3). A gene encoding vacuolarprotein sorting 26 (Vps26) was up-regulated during L-cysteine deprivation. In addition, several genes encodingg u a n i n en u c l e o t i d ee x c h a n g ef a c t o r s( R a s - G E F ) , GTPases, and GTPase activating proteins (GAPs) were also modulated in response to L-cysteine deprivation.Modulation of the genes encoding putative ankyrin andactin binding protein suggested that L-cysteine depriva-tion may affect cytoskeleton re-organization, mobility and vesicular trafficking." 90 1227 W2090290137.pdf 12 3 separator 0.9967927 ¶ 1227 1229 W2090290137.pdf 12 4 title 0.98181 Miscellaneous 1229 1243 W2090290137.pdf 12 5 separator 0.9958422 ¶ 1243 1245 W2090290137.pdf 12 6 text 0.99975234 "In addition to the modulation of above mentioned genesexpression of several other transcripts was also changedupon L-cysteine deprivation. For example, a transcriptfor a putative heat shock protein 20 was induced 4-5fold, and two WD40 domain- containing proteins were down-regulated 3-4 fold upo n L-cysteine deprivation (Additional files 2 and 3). WD-repeat proteins are alarge family found in almost all eukaryotes and impli- cated in a variety of cellular functions ranging from sig- nal transduction and transcription regulation to cellcycle control. One of the common functions of most ofthe WD-repeat proteins is to coordinate multi-proteincomplex assemblies [47]. Several genes encoding leu-cine-rich repeat proteins were down-regulated 3-6 foldat early time points upon L-cys teine deprivation (Addi- tional file 3). Leucine-rich repeats serve as recognition motifs for surface proteins in bacteria and eukaryotes." 1245 2180 W2090290137.pdf 12 7 separator 0.99684 ¶ 2180 2182 W2090290137.pdf 12 8 title 0.9888006 Repression of genes encoding ISF causes growth defects 2182 2237 W2090290137.pdf 12 9 separator 0.99247944 ¶ 2237 2239 W2090290137.pdf 12 10 text 0.9997192 "In order to further characterize the functional role of the genes induced upon L-cysteine deprivation, we uti-lized the epigenetic silencing in E. histolytica G3 strain to repress genes of interest [48,49]. Using this epigeneticsilencing strategy, we were able to repress ( ≥90%) two genes encoding ISFs (ISF1, EHI_138480 and ISF2,EHI_025710) that were highly induced gene upon L-cysteine deprivation (Figure 6A). However, we could notrepress the third highly induced gene (MFS;EHI_173950). Repression of ISF2, but not of ISF1,showed slight growth deflects when cultured in normalmedium. However, a severe growth defect in ISF2-repressed, and relatively mild growth defect in ISF1-repressed G3 trophozoites were observed in L-cysteine-deprived medium (Figure 6B). We also checked ifrepression of ISF1 or 2 also affects the tolerance of tro- phozoites to H 2O2mediated cytotoxicity. However, no significant difference in the tolerance to H 2O2cytotoxi- city was observed (Figure 6C ). L-Cysteine deprivation induced growth defects in ISF1- and 2-repressed G3 tro- phozoites suggest that in addition to their proposedroles in combating oxidative stress, ISF1 and 2 proteinsmay also play important roles under L-cysteine depriva-t i o n .T h e s eI S Fa r ev e r ys i m i l a rt ob a c t e r i a lN A D P H - dependent FMN reductases, which are induced upon sulfate or L-cysteine starvation [50]. In Escherichia coli, this enzyme, called a two-component alkanesulfonatemonooxygenase, allows utilization of alkanesulfonates assulfur sources under sulfate or cysteine starvation [29].However, it still remains unclear whether ISFs in Enta- moeba are also involved in similar processes." 2239 3946 W2090290137.pdf 12 11 separator 0.99693024 ¶ 3946 3948 W2090290137.pdf 12 12 title 0.9903136 Conclusions 3948 3960 W2090290137.pdf 12 13 separator 0.9962966 ¶ 3960 3962 W2090290137.pdf 12 14 text 0.999117 "This study represents the first genome-wide analysis oftranscriptional changes induced by L-cysteine depriva-tion in protozoan parasites, and in eukaryotic organismswhere L-cysteine represents the major intracellular thiol.We showed global changes in the expression of genesimplicated in metabolism, signalling, oxidative defence,DNA/RNA regulation, and transport. Although a large number of genes were modulated upon L-cysteine deprivation, significant transcriptional changes in genesinvolved in SAA metabolism were not observed, whichconfirmed that changes in the metabolic flux acrossSAA metabolism are not caused by the changes in theexpression of corresponding genes. Similarly, we alsoshowed that the changes in the gene expression inducedby L-cysteine deprivation are not shared by those induced by oxidative or nitrosative stress. The most important changes that occurred upon L-cysteine depri-vation were the induction of iron sulfur flavoproteinsand major facilitator super-family transporter. Repres-sion of ISF1 and 2 genes caused growth defects underL-cysteine-deprived conditions. Further studies on thekinetic and biochemical analysis of ISFs and MFS trans-porter, and their regulation should help to better under- stand the physiological role of these proteins in the biology of E. histolytica . L-Cysteine depletion mediated time-dependent changes in the expression of RENTssuggest that similar to other eukaryotic cells, NMD mayalso be functional in E. histolytica . This study also con- firmed that most of the L-cysteine deprivation-mediatedmetabolomic changes in amino acid, central energy, andphospholipid metabolism are not associated with theHusain et" 3962 5655 W2090290137.pdf 12 15 paratext 0.9371616 "al .BMC Genomics 2011, 12:275 http://www.biomedcentral.com/1471-2164/12/275Page 13 of 18" 5655 5746 W2090290137.pdf 12 0 paratext 0.98773205 fmicb-12-681014 July 14, 2021 Time: 15:11 # 2 0 45 W3178822845.pdf 1 1 separator 0.94181925 ¶ 45 47 W3178822845.pdf 1 2 title 0.96870136 Wu et al. Effect of Multispecies Probiotic on Dairy Calves 47 106 W3178822845.pdf 1 3 separator 0.8969713 ¶ 106 108 W3178822845.pdf 1 4 text 0.99816936 "of diarrhea in pre-weaning calves (during the first 4 weeks of life). There was a significant improvement in growth performance, reduction in calf diarrhea, balance in the fecal microbiota, and an overall improvement in serum immunity, compared with the control group. We, therefore, recommend adding 2 g/day of multispecies probiotic mixture supplementation in diets of dairy calves during their first 4 weeks of life before weaning." 108 548 W3178822845.pdf 1 5 separator 0.9755812 ¶ 548 550 W3178822845.pdf 1 6 text 0.7202191 Keywords: multispecies probiotic, growth, diarrhea, microbiota, calves 550 621 W3178822845.pdf 1 7 separator 0.9960326 ¶ 621 623 W3178822845.pdf 1 8 title 0.96376926 INTRODUCTION 623 636 W3178822845.pdf 1 9 separator 0.9906131 ¶ 636 638 W3178822845.pdf 1 10 text 0.9948445 "Neonatal diarrhea occurs frequently in dairy calves all over the world, causing huge economic and productivity losses that undermine healthy and sustainable development of animal husbandry (Donovan et al., 1998, 2002; El-Seedy et al., 2016). Moreover, even if calves recover from the diarrhea, their subsequent growth and development are hindered, which later affects their productivity in adulthood (Heinrichs and Heinrichs, 2011). Generally, feed supplementation could reduce the incidence of diarrhea and improve the health of calves." 638 1191 W3178822845.pdf 1 11 separator 0.5195571 1191 1192 W3178822845.pdf 1 12 text 0.99449795 "¶ Therefore, it is very important to determine the application of effective antidiarrheal agents (Caruso, 2018; Wang et al., 2018; Zhao et al., 2018) in dairy farming since the European Union (Casewell et al., 2003) and China (Ministry of agriculture and rural areas, 2019) prohibited the use of antimicrobial growth promoters." 1192 1528 W3178822845.pdf 1 13 separator 0.9707396 ¶ 1528 1530 W3178822845.pdf 1 14 text 0.9897138 "In 2014, the International Association of Probiotics and Prebiotic Sciences (ISAPP) emphasized the importance of probiotics in improving the survivability of animals (Markowiak and ́Sli ̇zewska, 2018). Probiotics are defined as “living organisms that bring health benefits to the host at an appropriate dose” (Hill et al., 2014). Multispecies probiotics (MSPs) were more effective than single-strain probiotics, especially in treating antibiotic-associated diarrhea in children (Ki et al., 2012; Łukasik and Szajewska, 2018), improving animal growth performance (Renaud et al., 2019), resisting bacterial infection (Perdigon et al., 1990; Avila et al., 1995; Lema et al., 2001; Woof and Kerr, 2006; Ehrenstein and Notley, 2010; Collumbien et al., 2012; Crassini et al., 2018), weight gain after stimulation post-enteritis (Renaud et al., 2019), and improving intestinal microbiota (Cruywagen et al., 1996; Chen et al., 2015; He et al., 2017; Hod et al., 2018; Biagioli et al., 2019)." 1530 2540 W3178822845.pdf 1 15 separator 0.9851768 ¶ 2540 2542 W3178822845.pdf 1 16 text 0.99657565 "Multispecies probiotics [ Lactobacillus acidophilus (McFarland et al., 2018; Łukasik and Szajewska, 2018), Bacillus subtilis (Rui and Ma, 2020), Saccharomyces cerevisiae (Thévenot et al., 2015)] have achieved certain results in human application, and there are similar reports in animals. Studies have found that Lactobacillus acidophilus (Sharma et al., 2018), Bacillus subtilis (Sun et al., 2010; Zhang et al., 2017; Wood et al., 2019), and Saccharomyces cerevisiae (Fomenky et al., 2018; Villot et al., 2019) can improve calf growth performance by improving immune function and balancing the structure of intestinal microbiota. The objectives of this study are: (1) To evaluate whether MSP supplementation can reduce the incidence of diarrhea in pre-weaning calves whileimproving the growth performance. (2) To evaluate whether the MSP supplementation can improve serum immunity (IgA, IgG, and IgM) in pre-weaning calves. (3) To evaluate whether MSP supplementation can affect the diversity and composition of the fecal microbiota of pre-weaning calves." 2542 3628 W3178822845.pdf 1 17 separator 0.99648273 ¶ 3628 3630 W3178822845.pdf 1 18 title 0.9909728 MATERIALS AND METHODS 3630 3652 W3178822845.pdf 1 19 separator 0.9955157 ¶ 3652 3654 W3178822845.pdf 1 20 text 0.99698025 "This study has been approved by the ethics committee of the College of Animal Science and Technology, Shihezi University (No. A2019-155-01)." 3654 3799 W3178822845.pdf 1 21 separator 0.995525 ¶ 3799 3801 W3178822845.pdf 1 22 title 0.9675115 "Preparation of the Multispecies Probiotics Mixture" 3801 3854 W3178822845.pdf 1 23 separator 0.98978585 ¶ 3854 3856 W3178822845.pdf 1 24 text 0.9995124 "Probiotic strains of Lactobacillus acidophilus S5 (Wu, 2013), Bacillus subtilis No. Bzg988118 (Bao, 2013), and Saccharomyces cerevisiae SHZ2017 were provided by the Biological Feed Laboratory of the College of Animal Science and Technology, Shihezi University, China. In vitro analyses revealed that all three strains have the potential benefits of probiotics, inhibiting the growth of Gram-positive and Gram-negative pathogens (i.e., Escherichia coli K99, Salmonella , and Staphylococcus aureus ), resist low pH and bovine bile salts, and tolerance to artificial gastrointestinal environment (Wu et al., 2021)." 3856 4484 W3178822845.pdf 1 25 separator 0.9375441 ¶ 4484 4486 W3178822845.pdf 1 26 text 0.9994628 "Each of the three strains were cultured, respectively, in de Man, Rogosa, and Sharpe medium (MRS), yeast peptone dextrose (YPD), and Luria–Bertani (LB) medium (purchased from Qingdao Gaokeyuan Haibo Biotechnology Co., Ltd., Qingdao, China), where L. acidophilus was anaerobically cultured at 37C for 20 h, while S. cerevisiae and B. subtilis were cultured on a shaker at 37C for 20 h, as described by Dong et al. (2013) after cultivation. One liter of the bacterial culture enrichment was centrifuged at 4,000 rpm for 3 min to remove the bacterial supernatant. The precipitation was washed with 60 ml of sterile PBS buffer including 5% glycerol and 20% skim milk powder (Shu et al., 2015), then mixed with 0.25 kg bran and freeze dried. The ratio of the three strain probiotics complex was 3:3:1, representing L. acidophilus ,B. subtilis , and S. cerevisiae fermentum based on previous research (Wu et al., 2021)." 4486 5429 W3178822845.pdf 1 27 separator 0.9969562 ¶ 5429 5431 W3178822845.pdf 1 28 title 0.99066526 Animals and Diet 5431 5448 W3178822845.pdf 1 29 separator 0.99625814 ¶ 5448 5450 W3178822845.pdf 1 30 text 0.986685 "Forty Chinese Holstein female calves (age = 6 3 days, BW = 40.862.65 kg) were selected and randomly assigned into four treatment groups with 10 calves per group. All the ¶" 5450 5628 W3178822845.pdf 1 31 paratext 0.9860232 Frontiers in Microbiology | www.frontiersin.org 2 July 2021 | Volume 12 | Article 681014 5628 5717 W3178822845.pdf 1 0 paratext 0.9888383 Page 4 of 11 Shen et al. Applied Biological Chemistry (2022) 65:7 0 76 W4225078725.pdf 3 1 separator 0.9911401 ¶ 77 79 W4225078725.pdf 3 2 title 0.9924308 Detections of cytokines 79 103 W4225078725.pdf 3 3 separator 0.9934958 ¶ 103 105 W4225078725.pdf 3 4 text 0.9990082 "The level of TNF-α, NO and IL-6 in the supernatant of RAW264.7 cells of compound 18 was determined by ELISA." 105 220 W4225078725.pdf 3 5 separator 0.99552417 ¶ 220 222 W4225078725.pdf 3 6 title 0.9894292 Cytotoxicity assay 222 241 W4225078725.pdf 3 7 separator 0.9932283 ¶ 241 243 W4225078725.pdf 3 8 text 0.9947264 "HepG2 (hepatocellular), KB (oral epithelial), Hela (cervi - cal), MCF-7 (human breast) and A-549 (lung) cancer cell lines (provided by Shanghai Cell Bank) were maintained in RPMI 1640 at 37 °C supplemented with 10% FBS. Cytotoxicity was determined by the SRB method [12], with 5-fluorouracil (5-FU) as positive control. The IC50 value is calculated using the GraphPad 7.00 prism." 243 642 W4225078725.pdf 3 9 separator 0.9962863 ¶ 642 644 W4225078725.pdf 3 10 title 0.9895687 Western blot analysis 644 666 W4225078725.pdf 3 11 separator 0.99184906 ¶ 666 668 W4225078725.pdf 3 12 text 0.9993813 "Western blotting experiment was performed to investi - gate effect of compound 18 on protein level of p-IKBα, p-IKKα/β, NF-κB p-P65, P65, p-JAK2 and p-STAT3." 668 831 W4225078725.pdf 3 13 separator 0.8412818 ¶ 832 834 W4225078725.pdf 3 14 text 0.9992556 "RAW264.7 cells were dispensed in 6 well plates for 24–48 h. Cells were treated with HFPS and induced by LPS for 24–48 h. Cells were collected after treatment and lysed. The Western blot analysis were determined based on method described of Li et al. [13]." 834 1103 W4225078725.pdf 3 15 separator 0.99665105 ¶ 1103 1105 W4225078725.pdf 3 16 title 0.9883203 Results and discussion 1105 1128 W4225078725.pdf 3 17 separator 0.99477875 ¶ 1128 1130 W4225078725.pdf 3 18 text 0.9992401 "Twenty four limonoids 1–24 were isolated from the C. tabularis barks through repeated silica gel, C18 and Sephadex LH-20 column chromatography. 1–17 were identified as phragmalin limonoid orthoesters and 19–24 were norphragmalin limonoids from the spectroscopic data and confirmed with literature data." 1130 1450 W4225078725.pdf 3 19 separator 0.9194368 ¶ 1450 1452 W4225078725.pdf 3 20 text 0.9993083 "Tabularisin Q (1) was found as white amorphous pow - der, having molecular formula of C41H48O20 according to its HRESI-MS ion at m/z 883.2625 [M + Na]+ (calcd for C41H48O20Na, 883.2637) which indicated eighteen degrees of unsaturation. IR spectra indicated absorp - tion bands of hydroxy and ester moieties at 3489 and 1753 cm−1. 1H-NMR spectrum implied two singlet meth - yls (δH 0.89, 1.60), four acetyls (δH 2.22, 2.05, 2.07, 2.15), one methoxy (δH 3.81), a typical β substituted furan ring (δH 6.66, s; 7.71, s; 7.61, s), and one isobutyroyl [δH 1.11 (d, J = 4.3 Hz, 3H), 1.22 (d, J = 4.3 Hz, 3H) (Table 1)." 1452 2096 W4225078725.pdf 3 21 separator 0.9185106 ¶ 2097 2099 W4225078725.pdf 3 22 text 0.99920464 "13C-NMR spectra of 1 confirmed the existence of nine methyls and one methoxy, two methenes, six oxygen - ated and three olefinic methines, five oxygenated and one olefinic quaternary carbons, and six carbonyls (Table 1)." 2099 2329 W4225078725.pdf 3 23 separator 0.88907766 ¶ 2330 2332 W4225078725.pdf 3 24 text 0.9996026 "One furan ring, one isobutyryl, and six esters are 10 degrees unsaturated, and remaining 8 degrees unsatu - rated require an octacyclic core. The carbon signal at δC 119.3 (C-31) in 13C NMR spectra demonstrated that 1 was phragmalin limonoid orthoester [14, 15]. The 13, 14, 18 cyclopropane ring was noticed in HMBC spectra of H-18, H-17, and H-11 with C-13; H-17, H-30, H-18, and H-15 to C-14; and H-17, H-15, and H-12 to C-18, and was supported by the quarterly carbon signal of upfield displacement at δC 33.6 (C-13) and 31.1 (C-14) and meth - ylene at δC 16.2 (C-18) compared to that of phragmalin limonoids (Fig. 1A) [5]. The comprehensive analysis of 1, especially HMBC spectra confirmed the skeleton struc - ture of phragmalin limonoid, whose methoxy group is connected to C-7 (Fig. 1). NMR analysis showed presence of three acetoxy groups (δH2.15, 2.22, 2.05; δC 21.8, 171.7; 21.0, 169.3; 19.9, 171.7) at C-2, C-6 and C-15 based on the low-field judgment of C-2 at δC 82.7, C-6 at δC 70.6 and C-15 at δC 69.9 compared to 2 (Table 1). The HMBC correlation of H-3 and OAc-3, H-6 and OAc-6, and H-15 and OAc-15 confirmed this allocation (Fig. 1A)." 2332 3546 W4225078725.pdf 3 25 title 0.54695 Table 1 3546 3554 W4225078725.pdf 3 26 table 0.62665206 (continued) 3554 3566 W4225078725.pdf 3 27 separator 0.5078405 ¶ 3566 3568 W4225078725.pdf 3 28 table 0.99034613 "No. 1a2b18b δH (J inHz) δC δH (J inHz) δC δH (J inHz) δC 12-OAc 169.2 171.7 2.14 (s, 3H) 20.8 2.00 (s, 3H) 19.5 15-OAc 171.7 170.9 2.05 (s, 3H) 19.9 2.22 (s, 3H) 19.9 1′ 174.6 170.6 5.16 (m) 73.1 2′ 2.49 (m) 33.6 2.53 (m) 32.6 171.0 3′ 1.11 (d, 4.3, 3H) 19.3 1.11 (d, 5.7, 3H) 18.3 4′ 1.22 (d, 4.3, 3H) 19.3 1.60 (d, 5.7, 3H) 18.3 1′-OAc 170.9 2.19 (s, 3H) 19.5 2′-OMe 3.69 (s, 3H) 52.2 a Recorded in CDCl3 b Recorded in CD3OD" 3568 4025 W4225078725.pdf 3 0 paratext 0.9568582 "Clube and Hazemba 10.3389/frsus.2024.1300904 Frontiers in Sustainability 12 frontiersin.org" 0 95 W4392559662.pdf 11 1 title 0.9642603 "5.3 Ensure fundamental systems support circularity" 95 148 W4392559662.pdf 11 2 separator 0.98668694 ¶ 148 150 W4392559662.pdf 11 3 text 0.9996679 "Although complex and multifaceted, there are opportunities to reform how the existing systems operate to create an enabling environment for a CE. The findings point at economic, environmental, and social benefits by increasing collection rates; segregating wastes streams; and recycling. Most fundamentally, bolstering collection rates is imperative to reach the NDC targets, which were built on the assumption of 80% collection and landfilling by 2050 ( Republic of Zambia, 2021 ). There are opportunities for policymakers to support uptake of innovative approaches to improve affordability, as this appears – according to the findings and the literature - to be a limiting factor to improving basic waste servicing (Wragg and Lim, 2015 ; Chileshe and Moonga, 2019 ). Various avenues worthy of exploration emerged in the findings. For instance, properly enforcing the EPR might involve mandating the formation of Producer Responsibility Organizations (e.g., see AGS, 2022a , p. 9) or proper government collection of recovered fees (e.g., from the plastic bag levy), which could be injected into collection or circularity activities. Moreover, it was identified that there is potential to use existing payment services (e.g., pre-paid mobile phone credit mechanisms) to enable citizens to accessibly contribute to waste services. Socially inclusive policies have also been identified in the literature. For instance, Colombia has a stratum system where wealthier geographic zones cross-subsidize lower income neighborhoods ( Calderón Márquez and Rutkowski, 2020 ) whereas in Cameroon the collection fee is based on total household earnings (Sotamenou et al., 2019 )." 150 1893 W4392559662.pdf 11 4 separator 0.9731469 ¶ 1893 1895 W4392559662.pdf 11 5 text 0.9997358 "Accurate data systems are missing. Data could be improved by embracing novel technologies, such as digital systems and mobile business models. These approaches have gained support in the academic literature as both a source of community economic opportunity (e.g., digital platforms can connect waste collectors to buyers) and institutional value (e.g., providing real-time volume and composition data) ( Oyinlola et al., 2022 ). Hence, if championed by policymakers, these digital tools could be cost- effective and inclusive. Furthermore, accurate data is needed to set objectives and monitor progress ( Fitch-Roy et al., 2021 ), including for international agendas, such as NDCs and SDGs." 1895 2617 W4392559662.pdf 11 6 separator 0.9602218 ¶ 2618 2620 W4392559662.pdf 11 7 text 0.99970394 "Quantification of waste flows is also essential for prospective investors: if accurate data was available - and fundamental collection services were in place - then this could help stimulate new value chains to emerge. For example, if glass was collected and measured, then investors would be able to make informed decisions about the viability of starting a glass recycling plant." 2620 3018 W4392559662.pdf 11 8 separator 0.7373919 ¶ 3019 3021 W4392559662.pdf 11 9 text 0.9992498 "Therefore, developing fundamental systems will also foster circular innovation (discussed in section 5.5)." 3021 3131 W4392559662.pdf 11 10 separator 0.99709815 ¶ 3131 3133 W4392559662.pdf 11 11 title 0.9921249 "5.4 Strong implementation and enforcement" 3133 3178 W4392559662.pdf 11 12 separator 0.9943094 ¶ 3178 3180 W4392559662.pdf 11 13 text 0.99974036 "There was a sentiment that the general policy and legislative approach on paper could be compatible with the goals of the CE, but implementation has so far lagged. For instance, SWRMA ’s waste is a resource umbrella principle is fundamental but requires implementation of complimentary measures (e.g., SIs). Similar challenges have been identified in Zambia, such as regarding sustainable infrastructure ( Zulu et al., 2022 ) and the Zambia clean-up campaigns ( Chileshe and Moonga, 2019 )." 3180 3691 W4392559662.pdf 11 14 separator 0.8270563 ¶ 3691 3693 W4392559662.pdf 11 15 text 0.99970233 "Furthermore, low enforcement of implemented legislations can hinder the transformative impacts of policy. In this study the introduction of the EPR, which is well-aligned with circularity (Velis, 2017 ), has not had much impact since enforcement has been lax. This agrees with previous observations regarding this SI (e.g., AGS, 2022a ). However, policy reforms must be accompanied by consistent enforcement to be effective ( Chileshe and Moonga, 2019 ; Asare et al., 2023 ). Some possible reasons behind low enforcement could link to capacity and financial constraints, for instance a lack of physical presence of government ministries and agencies. This finding mirrors that of Zulu et al. (2022) who also found that the lack of physical presence of ZEMA means that there are no repercussions for non-compliance. The findings of this study are preliminary so it is important to fully examine the reasons behind these gaps, as studies indicate that they can be wide-ranging and intertwined ( Chileshe and Moonga, 2019 ; Behuria, 2021 ). Hence, this presents a valuable topic for more nuanced research." 3693 4849 W4392559662.pdf 11 16 separator 0.99713266 ¶ 4849 4851 W4392559662.pdf 11 17 title 0.993083 5.5 Foster circular innovation 4851 4882 W4392559662.pdf 11 18 separator 0.99541485 ¶ 4882 4884 W4392559662.pdf 11 19 text 0.9997441 "The findings indicate limited policy support for entrepreneurship and new entrants, which stifles innovation. Nonetheless, there are a growing number of empirical case studies of the commercial successes in the region, so investing in circularity may become more politically palatable overtime. Oyinlola et al. (2022) suggest that the growing diffusion of innovations will demonstrate the viability of business models as the market grows. Further, Godfrey et al. (2021) , suggest that these business models will become more attractive as market dynamics shift, such as when the costs of alternative management approaches increase; sustainability goals become more institutionalized; and regulation is enacted." 4884 5625 W4392559662.pdf 11 20 separator 0.9550721 ¶ 5625 5627 W4392559662.pdf 11 21 text 0.9996867 "As noted by other scholars in an African context, there is an opportunity for more proactive governance to foster circular value creation ( Muriithi and Ngare, 2023 ). In agreement with Banda et al. (2023) , the findings point to opportunities to support investment interest through SIs for sector-specific tax exemptions and benefits; tariff-free imports on equipment; investment funds and other fiscal incentives; and dedicated registration codes. Alongside capitalizing on existing mechanisms more strategically (e.g., CDF), the creation of dedicated investment schemes could harness circular innovation to complement other policy goals, as demonstrated by other strategies applied in the region (e.g., Rwanda introduced incentives for recycling in harmony with plastics reduction instruments) ( Adebiyi-Abiola et al., 2019 ; Syberg et al., 2021 ; Ogutu et al., 2023 ). A key question remains as to where funds might come from, and identifying effective finance mechanisms is important. It was suggested in the interviews that if the EPR was fully enforced then associated fees could be a readily available source of finance. Participation in regional programs (e.g., ACEA) may open-up funding opportunities, while providing case studies for entrepreneurship, knowledge transfer and collaborations ( Desmond and Asamba, 2019 )." 5627 7015 W4392559662.pdf 11 0 paratext 0.9438685 "¶ Journal of Experimental Biology and Agricultur al Science s http://www.jebas.org ¶" 1 95 W3209333570.pdf 29 1 separator 0.51501346 97 98 W3209333570.pdf 29 2 paratext 0.4879929 ¶ 98 99 W3209333570.pdf 29 3 separator 0.8865895 ¶ 101 103 W3209333570.pdf 29 4 paratext 0.59992284 Pharmaceutical potential of laboratory grown cultures of blue-green algae: a comprehensive review 104 202 W3209333570.pdf 29 5 title 0.4814704 and 202 206 W3209333570.pdf 29 6 paratext 0.6182122 future possibilities 570 206 256 W3209333570.pdf 29 7 separator 0.5595222 ¶ 256 257 W3209333570.pdf 29 8 paratext 0.51472473 ¶ 260 262 W3209333570.pdf 29 9 separator 0.49656036 264 265 W3209333570.pdf 29 10 paratext 0.5144841 ¶ 265 266 W3209333570.pdf 29 11 separator 0.4903069 268 269 W3209333570.pdf 29 12 paratext 0.5593689 ¶ 269 270 W3209333570.pdf 29 13 separator 0.48311093 272 273 W3209333570.pdf 29 14 paratext 0.5940305 ¶ 273 274 W3209333570.pdf 29 15 separator 0.52528656 276 277 W3209333570.pdf 29 16 paratext 0.59178114 ¶ 277 278 W3209333570.pdf 29 17 separator 0.6406559 280 281 W3209333570.pdf 29 18 paratext 0.4911962 ¶ 281 282 W3209333570.pdf 29 19 separator 0.6187053 ¶ 284 286 W3209333570.pdf 29 20 bibliography 0.79440695 "dependent and independent methods. Frontiers in Microbiology 10: 1018." 287 362 W3209333570.pdf 29 21 separator 0.98282397 ¶ 364 366 W3209333570.pdf 29 22 bibliography 0.99771166 "Reshef V, Mizrachi E, Maretzki T, Silberstein C, Loya S, Hizi A, Carmeli S (1997) New acetylated sulfoglycolipids and digalactolipids and related known glycolipids from cyanobacteria with potential to inhibit the reverse transcriptase of HIV -1. Journal of Natural Products 60: 1251 -1260." 366 668 W3209333570.pdf 29 23 separator 0.9838617 ¶ 670 672 W3209333570.pdf 29 24 bibliography 0.9976623 "Riba M, Kiss -Szikszai A, Gonda S, Parizsa P, Deák B, Török P, Vasas G (2020) Chemotyping of terrestrial Nostoc -like isolates from alkali grassland areas by non -targeted peptide analysis. Algal Research 46: 101798." 672 900 W3209333570.pdf 29 25 separator 0.98190737 ¶ 902 904 W3209333570.pdf 29 26 bibliography 0.99793077 "Rippka R, Deruelles J, Waterbury JB, Herdman M, Stanier RY (1979) Generic assignments, strain histories and properties of pure cultures of cyanobacteria. Microbiology 111: 1 - 61." 904 1091 W3209333570.pdf 29 27 separator 0.9781998 ¶ 1092 1094 W3209333570.pdf 29 28 bibliography 0.99780846 "Romay C, Ledon N, Genzalez R (1999) Phycocyanin extract reduces leukotriene B4 levels in arachidonic acid -induced mouse - earinflammation test. Journal of Pharmacy and Pharmacology 51(5): 641 -642." 1094 1301 W3209333570.pdf 29 29 separator 0.9847233 ¶ 1302 1304 W3209333570.pdf 29 30 bibliography 0.99725497 "Safari R, Raftani Amiri Z, Esmaeilzadeh Kenari R (2020) Antioxidant and anti bacterial activities of C -phycocyanin from common name Spirulina platensis. Iranian Journal of Fisheries Sciences 19(4): 1911 -1927." 1304 1526 W3209333570.pdf 29 31 separator 0.98067474 ¶ 1528 1530 W3209333570.pdf 29 32 bibliography 0.9980515 "Sami N, Ahmad R, Fatma T (2021) Exploring algae and cyanobacteria as a promising natural source of antiviral drug against SARS -CoV-2 Biomedical Journal 44(1) 54 -62." 1530 1703 W3209333570.pdf 29 33 separator 0.98264295 ¶ 1704 1706 W3209333570.pdf 29 34 bibliography 0.99769944 "Saurav K, Macho M, Kust A, Delawská K, Hájek J, Hrouzek P (2019) Antimicrobial activity and bioactive profiling of heterocytous cyanobacterial strains using MS/MS -based molecular networking. Folia Microbiologica 6 4(5): 645 -654." 1706 1946 W3209333570.pdf 29 35 separator 0.9843822 ¶ 1947 1949 W3209333570.pdf 29 36 bibliography 0.99804807 "Schaeffer DJ, Krylov VS (2000) Anti -HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicology and Environmental safety 45(3):208 -27." 1949 2115 W3209333570.pdf 29 37 separator 0.9785403 ¶ 2116 2118 W3209333570.pdf 29 38 bibliography 0.99803203 "Schwartz J, Shklar G, Reid S, and Trickler D (1988) Prevention of experimental oral cancer by extracts of Spirulina -Dunaliella algae. Nutrition and Cancer 11 (2); 127-134." 2118 2301 W3209333570.pdf 29 39 separator 0.98229086 ¶ 2302 2304 W3209333570.pdf 29 40 bibliography 0.99676925 "Seddek NH, Fawzy MA, El -Said WA, Ahmed MMR (2019) Evaluation of antimicrobial, antioxidant and cytotoxic activities and characterization of bioactive substances from f reshwater blue - green algae. Global Nest Journal 21(3): 328 -336." 2304 2550 W3209333570.pdf 29 41 separator 0.98335606 ¶ 2551 2553 W3209333570.pdf 29 42 bibliography 0.99760735 "Senousy HH, Abd Ellatif S, Ali S (2020) Assessment of the antioxidant and anticancer potential of different isolated strains of cyanobacteria and microalgae from soil and agriculture drain water. Environmental Science and Pollution Research 27: 18463 – 18474." 2553 2821 W3209333570.pdf 29 43 separator 0.98651457 ¶ 2823 2825 W3209333570.pdf 29 44 bibliography 0.9980143 "Shi SR, Cote RJ, Taylor CR (1999) Standardization and further development of antigen retrieval immunohistochemistry: strategies and future goals. Journal of Histotechnology 22(3):177 -92." 2825 3019 W3209333570.pdf 29 45 separator 0.98372245 ¶ 3020 3022 W3209333570.pdf 29 46 bibliography 0.9979353 "Shishido TK, Popin RV, Jokela J, Wahlsten M, Fiore MF, Fewer DP, Herfindal L, Sivonen K (2020) Dereplication of natural products with antimicrobial and anticancer activity from Brazilian cyanobacteria. Toxins 12(1):12.DOI: 10.3390/toxins12010012." 3022 3278 W3209333570.pdf 29 47 separator 0.9813521 ¶ 3280 3282 W3209333570.pdf 29 48 bibliography 0.99801207 "Singh IP, M illigan KE, Gerwick WH (1999) Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya m ajuscula. Journal of Natural Products 62(9):1333 -5." 3282 3467 W3209333570.pdf 29 49 separator 0.9783249 ¶ 3468 3470 W3209333570.pdf 29 50 bibliography 0.9979704 "Singh SM, Elster JOSEF (2007) Cyanobacteria in Antarctic lake environments. In: Algae and cyanobacteria in extreme environments. Springer, Dordrecht Pp. 303 -320." 3470 3640 W3209333570.pdf 29 51 separator 0.9807776 ¶ 3641 3643 W3209333570.pdf 29 52 bibliography 0.99797624 "Singh U, Singh AK, Asthana RK (2021a) Bioactive molecules from microalgae and constraints in commercialization. Natural Bioactive Compounds Pp. 143 -164." 3643 3804 W3209333570.pdf 29 53 separator 0.9737716 ¶ 3805 3807 W3209333570.pdf 29 54 bibliography 0.9979162 "Singh U, Singh P, Singh AK, Kum ar D, Tilak R, Shrivastava SK, Asthana RK (2021b) Identification of antifungal and antibacterial biomolecules from a cyanobacterium, Arthrospira platensis . Algal Research 54:102215." 3807 4031 W3209333570.pdf 29 55 separator 0.98078024 ¶ 4033 4035 W3209333570.pdf 29 56 bibliography 0.99752724 "Smetana S, Sandmann M, Rohn S, Pleissner D, Heinz V (2017) Autotrophic and heterotrophic microalgae and cyanobacteria cultivation for food and feed: life cycle assessment. Bioresource Technology 245: 162 -170." 4035 4257 W3209333570.pdf 29 57 separator 0.9793757 ¶ 4258 4260 W3209333570.pdf 29 58 bibliography 0.9980046 "Spoehr HA, Milner HW (1949) The chemical composition of Chlorella; effect of environmental conditions. Plant physiology 24(1):120." 4260 4397 W3209333570.pdf 29 59 separator 0.96863604 ¶ 4399 4401 W3209333570.pdf 29 60 bibliography 0.9981513 "Sridhar K, Inbaraj BS, Chen BH(2021) Recent developments on production, purification and biological activity of marine peptides. Food Research International 147: p.110468." 4401 4581 W3209333570.pdf 29 61 separator 0.9775411 ¶ 4583 4585 W3209333570.pdf 29 62 bibliography 0.99799126 "Srivastava VC, Manderson GJ, Bhamidimarri R (1999) Inhibitory metabolites production by the cyanobacterium Fischerellamuscicola. Microbiological Research 153(4):309 -17." 4585 4761 W3209333570.pdf 29 63 separator 0.968735 ¶ 4762 4764 W3209333570.pdf 29 64 bibliography 0.9978463 "Stanier G (1988) Fine structure of cyanobacteria. Methods in Enzymology 167:157 -172." 4764 4855 W3209333570.pdf 29 65 separator 0.97861797 ¶ 4856 4858 W3209333570.pdf 29 66 bibliography 0.9944146 "Stevenson CS, Capper EA, Roshak AK, Marquez B, Eichman C, Jackson JR, Mattern M, Gerwick WH, Jacobs RS, Marshall LA (2002) The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore." 4858 5115 W3209333570.pdf 29 0 paratext 0.9820449 Rev Assoc Med Bras 2004; 50(1): 1-20 19 0 39 W2045349554.pdf 1 1 title 0.96687514 DISCUSSÃO 39 48 W2045349554.pdf 1 2 separator 0.9954355 ¶ 48 50 W2045349554.pdf 1 3 text 0.99358845 "A síndrome de Goodpasture é uma patologia mediada pelo sistema imuno-lógico, na qual auto-anticorpos contra acadeia a 3 (IV) do colágeno tipo IV se ligamà membrana basal, alveolar e glomerular,causando glomerulonefrite progressiva ehemorragia pulmonar. Descrita inicial-mente como uma síndrome pulmão-rim,em 1919 por Goodpasture 1,2, o epônimo foi primeiramente utilizado por Stanton eTange em 1958. A presença de auto-anticorpos apresentando depósito linearfoi demonstrada nos anos 60 3. O mecanismo de injúria renal e pulmonar é complexo. No rim, osanticorpos se ligam à membrana basal, ati-vam a cascata do complemento e deproteases, tal ativação provoca ruptura dabarreira glomerular e da cápsula deBowman, causando proteinúria, hema-túria e facilitando a formação de cres-centes. O setor celular com os linfócitosT CD4 e CD8+, macrófagos e neutrófilosparticipam da agressão produzindo, entreoutros, interleucina 12 e interferon g quemedeiam a formação de crescentes " 50 1034 W2045349554.pdf 1 4 separator 0.50349116 ¶ 1034 1035 W2045349554.pdf 1 5 text 0.9943485 "4. A doença apresenta maior prevalência na população branca, com distribuiçãoetária bimodal, com maior freqüênciaaos 30 e aos 60 anos. Grande parte dospacientes apresenta combinação de glome-rulonefrite rapidamente progressiva e he-morragia alveolar, podendo em 30% a40% dos casos exibir acometimento renalisolado caracterizado por hematúria,D iscussão de casoiscussão de casoiscussão de casoiscussão de casoiscussão de caso proteinúria leve a moderada, ou mesmo insuficiência renal aguda. O acometimentopulmonar é mais comum em homens jo-vens, manifesta-se clinicamente por disp-néia e tosse, com ou sem hemoptise.A presença de infiltrado alveolar ao raio-Xsimples de tórax pode acompanhar o caso,porém é pouco específico. Anticorpos anticitoplasma de neutrófilo (Anca) estão presentes em 30% dos pacientes com doença antimembrana basal 5. Ao contrário de outras vasculites Anca positiva, histologicamente o padrão dadoença é tipicamente monofásico, comlesões glomerulares de estadio de evolu- ção semelhante 6. No exame de imuno- fluorescência quase todos os pacientesapresentam depósitos lineares de IgG namembrana basal, C3 e, ocasionalmente,IgA e IgM." 1035 2232 W2045349554.pdf 1 6 separator 0.9895103 ¶ 2232 2234 W2045349554.pdf 1 7 text 0.99900925 "A doença não tratada geralmente apresenta um prognóstico ruim. A intro- dução do tratamento combinado de plas-maferese (remoção de anticorpos pato-gênicos), agentes alquilantes tais como aciclofosfamida (prevenção de síntese de novos anticorpos) e corticoterapia (ação antinflamatória) revolucionaram a evolu-ção da doença." 2234 2566 W2045349554.pdf 1 8 separator 0.94623804 ¶ 2566 2568 W2045349554.pdf 1 9 text 0.9994526 "O prognóstico na apresentação do quadro clinico é pior se há oligúria, fibro-se renal avançada ou mais que 50% de crescentes na biópsia renal. Nível eleva- do de creatinina (creatinina pré-trata-mento > 6,6 mg/dl) ou necessidade dediálise também se associam com piorevolução. A sobrevida em um ano é cerca de 75% a 90%." 2568 2896 W2045349554.pdf 1 10 separator 0.98535657 ¶ 2896 2898 W2045349554.pdf 1 11 text 0.9976771 "Pacientes com doença renal terminal que apresentam hemoptise devem sertratados. O quadro pulmonar é, freqüen-temente, responsivo a plasmaferese. A pre-sença de hemorragia alveolar é indicaçãoformal de tratamento intensivo, a despeitoda severidade do acometimento renal." 2898 3170 W2045349554.pdf 1 12 separator 0.9925487 ¶ 3170 3172 W2045349554.pdf 1 13 contact 0.9952363 "CARLOS ALBERTO BALDA MARCELLO FABIANO DE FRANCO ANDREI ALKMIM TEIXEIRA , ERIKA FERRAZ HELENA MENDONÇA DISCIPLINA DE NEFROLOGIA DA UNIVERSIDADE FEDERAL DE SÃO PAULO – UNIFESP-EPM, S ÃO PAULO, SP." 3172 3390 W2045349554.pdf 1 14 separator 0.9906957 ¶ 3390 3392 W2045349554.pdf 1 15 title 0.44307935 Referências 3392 3404 W2045349554.pdf 1 16 separator 0.9846762 ¶ 3404 3406 W2045349554.pdf 1 17 bibliography 0.99094045 "1. Salama AD, Levy JB, Lightstone L, Pusey CD: Goodpasture’s disease. Lancet 2001; 358:917-20. 2. Bolton WK, Nephrology Forum: Good- pasture’s syndrome. Kidney Int 1996;50:1753-66." 3406 3595 W2045349554.pdf 1 18 separator 0.66597563 ¶ 3595 3597 W2045349554.pdf 1 19 bibliography 0.997934 "3. Stanton MC, Tange JD: Goodpasture’s syndrome. Aust N Z J Med 1958; 7:132-44.4. Jayne DR, Marshall PD, Jones SJ, Lockwood CM: Autoantibodies to GBM and neutrophil cytoplasm in rapidly progressive glomerulo-nephritis. Kidney Int 1990; 37:965-70." 3597 3850 W2045349554.pdf 1 20 separator 0.790768 ¶ 3850 3852 W2045349554.pdf 1 21 bibliography 0.99763376 "5. Pusey CD: Anti-glomerular basement membrane disease. Kidney Int 2003;64:1535-50." 3852 3938 W2045349554.pdf 1 22 separator 0.8528641 ¶ 3938 3940 W2045349554.pdf 1 23 bibliography 0.99781775 "6. Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG: Alport’s syndrome, good-pasture’s syndrome, and type IV collagen. New Engl J Med 2003; 348:2543-56." 3940 4102 W2045349554.pdf 1 0 paratext 0.99047494 Page 4 of 9 0 11 W4324143825.pdf 3 1 separator 0.60862803 11 12 W4324143825.pdf 3 2 paratext 0.95999825 ¶ Kim et al. BMC Musculoskeletal Disorders (2023) 24:191 12 78 W4324143825.pdf 3 3 separator 0.99244756 ¶ 79 81 W4324143825.pdf 3 4 title 0.988892 Subsequent surgery 81 100 W4324143825.pdf 3 5 separator 0.99416184 ¶ 100 102 W4324143825.pdf 3 6 text 0.99885267 "The 430 hybrid surgery patients contributed 436 proce - dural episodes to the subsequent surgery analysis, while the 2,136 mACDF patients contributed 2,180 episodes." 102 273 W4324143825.pdf 3 7 separator 0.97569466 ¶ 274 276 W4324143825.pdf 3 8 text 0.99696976 "Rates of subsequent surgery accounting for follow-up time were comparable across hybrid surgery and mACDF cohorts (Table 3). The hybrid surgery cohort had a rate of 1.9 surgeries/100 patient-years compared to a rate of 1.8 surgeries/100 patient-years for the mACDF cohort. The 2-level primary cohorts tended to have the lowest rates of subsequent surgery at 1.2 and 1.7 surgeries/100 patient- years in the hybrid surgery and mACDF cohorts, respec - tively. Rates of subsequent surgery increased slightly in the 3 +-level primary cohorts with the hybrid surgery and mACDF patients evidencing subsequent surgery rates at 2.2 and 1.8 surgeries/100 patient-years, respectively." 276 982 W4324143825.pdf 3 9 separator 0.9350655 ¶ 983 985 W4324143825.pdf 3 10 text 0.99916863 "The secondary surgery sub-cohorts had the highest rates of subsequent surgery with 5.5 surgeries/100 patient- years in the hybrid surgery cohort and 1.9 surgeries/100 patient-years in the mACDF cohort." 985 1195 W4324143825.pdf 3 11 separator 0.99678266 ¶ 1195 1197 W4324143825.pdf 3 12 title 0.98664874 Hospitalizations 1197 1214 W4324143825.pdf 3 13 separator 0.99563324 ¶ 1214 1216 W4324143825.pdf 3 14 text 0.99932736 "In the first 30 days following the first or second proce - dural episode there were 20 (4.6%) and 99 (4.5%) episodes with ≥1 all-cause hospitalization in the hybrid surgery cohort and mACDF cohorts respectively. A majority (77.3%) of these hospitalizations were spinal surgery- related, with 16 (3.7%) episodes in the hybrid surgery cohort and 76 (3.5%) episodes in the mACDF cohort." 1216 1616 W4324143825.pdf 3 15 separator 0.9511726 ¶ 1617 1619 W4324143825.pdf 3 16 text 0.9994323 "Overall, the average time to all-cause hospitalization (7.0 vs. 8.9 days) and rate of all-cause hospitalization (0.67% vs. 0.87% hospitalized/patient-year) were simi - lar between the hybrid surgery and mACDF cohorts respectively. Among the sub-cohorts the only difference between the hybrid surgery and mACDF patients was observed between the secondary surgery groups, with the secondary hybrid surgery sub-cohort evidencing a higher frequency of episodes with an all-cause hospi - talization (12.5% vs. 2.6%; p < 0.01) and a higher rate of 30-day all-cause hospitalization (1.64% vs. 0.33% hospi - talized/patient-year; p < 0.05) compared to the secondary mACDF sub-cohort (Table 3)." 1619 2336 W4324143825.pdf 3 17 separator 0.98786354 ¶ 2336 2338 W4324143825.pdf 3 18 text 0.99720603 "At 90 days post-procedure there were 20 (4.6%) epi - sodes with ≥1 hospitalization in the hybrid surgery cohort, indicating no additional episodes with a hospi - talization past 30 days post-procedure. There were 140 (6.4%) episodes with a hospitalization in the 90 days fol - lowing the surgical procedure in the mACDF cohort." 2338 2678 W4324143825.pdf 3 19 separator 0.8799597 ¶ 2679 2681 W4324143825.pdf 3 20 text 0.99956334 "Again, the majority of hospitalizations at 90 days were classified as spinal surgery related (Table 3). The hybrid surgery cohort had a significantly shorter time to hospi - talization at 90 days both for all-cause (7.0 vs. 24.5 days; p < 0.01) and spinal surgery-related hospitalizations (7.6 vs. 22.9 days; p < 0.05) compared to the mACDF cohort." 2681 3045 W4324143825.pdf 3 21 separator 0.9781104 ¶ 3046 3048 W4324143825.pdf 3 22 text 0.99955916 "Consistent with the lack of new episodes with a hospital - ization post-30 days, the rate of all-cause hospitalization at 90 days was lower for the hybrid surgery cohort com - pared to the mACDF cohort (0.23% vs. 0.42% hospital - ized/patient-year; p < 0.05). Within the sub-cohorts, the frequency of episodes with a 90-day all-cause hospital - ization (3.0% vs. 6.5%; p < 0.05) and the rate of all-cause 90-day hospitalizations (0.14% vs. 0.42% hospitalized/ patient-year; p < 0.05) were significantly lower in the 2-level primary hybrid surgery cohort compared to the 2-level primary mACDF cohort. Conversely, the fre - quency of episodes with a 90-day all-cause hospitaliza - tion (12.5% vs. 4.2%; p < 0.05) and rate of 90-day all-cause hospitalizations (0.57% vs. 0.18% hospitalized/patient- year; p < 0.05) were higher in the secondary hybrid sur - gery cohort compared to the secondary mACDF cohort." 3048 3990 W4324143825.pdf 3 23 separator 0.99724495 ¶ 3990 3992 W4324143825.pdf 3 24 title 0.98881006 Discussion 3992 4003 W4324143825.pdf 3 25 separator 0.9966142 ¶ 4003 4005 W4324143825.pdf 3 26 text 0.99946666 "The goal of hybrid surgery is to provide the most suit - able treatment for each cervical disc, making the proce - dure appropriate for select patients with different types of disease and different degrees of degeneration at adja - cent levels. This retrospective analysis of administrative claims-based data utilized the MarketScan Commercial and Medicare Supplemental Databases to investigate rates of subsequent surgery and hospitalization between patients undergoing hybrid surgery or mACDF to treat multilevel cervical degenerative disc disease. This study is one of the largest known analyses of real-world outcomes in patients receiving hybrid surgery to date." 4005 4703 W4324143825.pdf 3 27 title 0.6949805 Table 1 Sample Attrition 4703 4728 W4324143825.pdf 3 28 table 0.99379927 "¶ Inclusion/Exclusion Criteria Hybrid SurgerymACDF N % N % Evidence of hybrid surgery or multilevel ACDF between January 1, 2014 and June 30, 2020 (first surgical procedure serves as the index date)558 100% 61,625 100% AND Age 18 or older on index 558 100% 61,587 99.90% AND Continuous enrollment for 36 months prior to index444 79.60% 46,775 75.90% AND No evidence of ACDF or CDA procedures prior to index441 79.00% 46,464 75.40% AND No evidence of other related spinal surgeries in the pre-period (Total Pre-Match Sample)430 77.10% 45,818 74.30% Pre-match Sub-cohorts 2-level primary 262 60.90% 43,448 94.80% 3+-level primary 131 30.50% 1540 3.40% Secondary 37 8.60% 830 1.80% Post-match Samples Total Cohort 430 100% 2,136 100% 2-level primary 262 60.90% 1,310 61.30% 3+-level primary 131 30.50% 641 30.00% Secondary 37 8.60% 185 8.70%" 4728 5686 W4324143825.pdf 3 0 paratext 0.9669355 "INTERNATIONAL JOURNAL OF ACADEMIC RESEARCH IN PROGRESSIVE EDUCATION AND DEVELOPMENT Vol. 13, No. 1, 2024, E-ISSN: 222 6-6348 © 2024 127" 0 144 W4390750210.pdf 13 1 separator 0.96269494 ¶ ¶ 145 151 W4390750210.pdf 13 2 bibliography 0.99352807 "Sorrentino, C. (2019). Creativity assessment in school: Reflection from a middle school italian study on giftedness. Universal Journal of Educational Research, 7 (2), 556 -562. doi:10.13189/ujer.2019.070228" 152 365 W4390750210.pdf 13 3 separator 0.98522985 ¶ 367 369 W4390750210.pdf 13 4 bibliography 0.9977948 "Subotnik, R. F., Olszewski -Kubilius, P., & Worrell, F. C. (2021). The Talent Development Megamodel: A Domain -Specific Conceptual Framework Based on the Psychology of High Performance. In R. J. Sternberg & D. Ambrose (Eds.), Conceptions of Giftedness and Talent (pp. 425 -442). Cham: Springer International Pu blishing." 369 701 W4390750210.pdf 13 5 separator 0.9748893 ¶ 703 705 W4390750210.pdf 13 6 bibliography 0.99763113 "Tushnova, Y. (2020). Features of Social -Perceptual Properties of Mathematically Gifted Students. International Journal of Cognitive Research in Science, Engineering and Education (IJCRSEE), 8 (Special issue), 103 -112. doi:10.23947/2334 -8496 -2020 -8-SI-103-" 705 972 W4390750210.pdf 13 7 separator 0.852543 ¶ 972 974 W4390750210.pdf 13 8 paratext 0.6150193 112 974 978 W4390750210.pdf 13 9 separator 0.9767569 ¶ 979 981 W4390750210.pdf 13 10 bibliography 0.9973139 "United States Department of Education (2015). The Every Student Succeeds Act. https://www.congress.gov/bill/114th -congress/senate -bill/1177/text" 981 1132 W4390750210.pdf 13 11 separator 0.9794869 ¶ 1134 1136 W4390750210.pdf 13 12 bibliography 0.99712735 "Vogelaar, B., Sweijen, S. W., & Resing, W. C. M. (2019). Gifted and average -ability children’s potential for solving analogy items. Journal of Intelligence, 7 (3). doi:10.3390/jintelligence7030019" 1136 1340 W4390750210.pdf 13 13 separator 0.97949475 ¶ 1342 1344 W4390750210.pdf 13 14 bibliography 0.9978189 "Wechsler, S. M., Virgolim, A. M. R., Paludo, K. I., Dantas, I., Mota, S. P., & Minervino, C. A. M. (2022). Integrated assessment of children’s cognitive and creative abilities: Psychometric studies. Psico -USF, 27 (4), 721 -734. doi:10.1590/1413 -82712022270410" 1344 1612 W4390750210.pdf 13 15 separator 0.97757 ¶ 1614 1616 W4390750210.pdf 13 16 bibliography 0.9962393 "Zaia, P., Nakano, T. C., & Peixoto, E. M. (2018). Scale fo r identification of characteristics of giftedness: Internal structure analysis. Estudos de Psicologia (Campinas), 35 (1), 39 -51. doi:10.1590/1982 -02752018000100005" 1616 1847 W4390750210.pdf 13 17 separator 0.9896572 ¶ ¶ 1849 1855 W4390750210.pdf 13 0 text 0.95398694 "transfer needed toprevent catastrophic costs byadding thevalue oforiginal cash transfer to ourestimated value ofadditional cash transfer needed toprevent catastrophic costs." 0 175 W2768092287.pdf 10 1 separator 0.994619 ¶ 175 177 W2768092287.pdf 10 2 text 0.6816545 Estimation of 177 191 W2768092287.pdf 10 3 title 0.52657926 TB 191 193 W2768092287.pdf 10 4 text 0.5503028 -specific and 193 206 W2768092287.pdf 10 5 title 0.5507232 TB 206 209 W2768092287.pdf 10 6 text 0.5860646 - 209 210 W2768092287.pdf 10 7 title 0.60386217 sensitive cash 210 224 W2768092287.pdf 10 8 text 0.99355155 "transfer budget needed toprevent cata- strophic costs. Toestimate thecountry-level budget that countries would need toprevent catastrophic costs forallpoor households targeted with aTB-specific versus aTB-sensitive approach, weconsidered that foreach approach avalue ofcash transfer sufficient toprevent catastrophic costs would beprovided toalltargeted households. Thus, wemultiplied countries' estimated TB-specific and TB-sensitive household-level total cash transfer needed toprevent catastrophic costs bythesizeofeach approach's target population, which foraTB-specific approach wasallhouseholds with aconfirmed TBdiagnosis inthecountries' poorest popula- tion quintile, and foraTB-sensitive approach washouseholds inpoverty already targeted by countries' established governmental poverty-reduction cash transfer programme." 224 1071 W2768092287.pdf 10 9 separator 0.99751556 ¶ 1071 1073 W2768092287.pdf 10 10 title 0.99224883 Sensitivity analysis 1073 1094 W2768092287.pdf 10 11 separator 0.99582136 ¶ 1094 1096 W2768092287.pdf 10 12 text 0.9996824 "Wetested thesensitivity ofourresults inBrazil, Colombia, Tanzania, and Mexico toimputa- tion ofmissing DSTB-related cost components byrepeating ouranalysis omitting rather than imputing thevalue ofmissing DSTB-related cost components [7].Weseparately tested the sensitivity ofourresults across allcountries included inthestudy totheuseof20% asthe threshold formeasuring countries' TB-related cost burden ascatastrophic. Wedidthisby repeating ouranalyses instead using a10% and 30% threshold." 1096 1598 W2768092287.pdf 10 13 separator 0.9974873 ¶ 1598 1600 W2768092287.pdf 10 14 title 0.9284179 Results 1600 1608 W2768092287.pdf 10 15 separator 0.9959372 ¶ 1608 1610 W2768092287.pdf 10 16 caption 0.93361545 "Fig1isaflow chart ofthereview process forassessing theeligibility ofcountries forinclusion inthisstudy. Argentina, Bangladesh, and South Africa hadtobeexcluded after in" 1610 1781 W2768092287.pdf 10 17 text 0.5000213 sufficient 1781 1791 W2768092287.pdf 10 18 caption 0.70251757 ¶ publically available background 1791 1825 W2768092287.pdf 10 19 text 0.6107273 information was 1825 1841 W2768092287.pdf 10 20 caption 0.55064565 i 1841 1842 W2768092287.pdf 10 21 text 0.6070561 dentified 1842 1851 W2768092287.pdf 10 22 caption 0.60224223 foreligible cash 1851 1868 W2768092287.pdf 10 23 text 0.6069751 transfer 1868 1877 W2768092287.pdf 10 24 caption 0.6044771 pro- 1877 1882 W2768092287.pdf 10 25 text 0.5525025 ¶ 1882 1884 W2768092287.pdf 10 26 caption 0.6211924 grammes inthese 1884 1900 W2768092287.pdf 10 27 text 0.8880347 countries. Consequently, 7countries were included inthedata analysis. 1900 1970 W2768092287.pdf 10 28 separator 0.9966545 ¶ 1970 1972 W2768092287.pdf 10 29 title 0.99337155 Summary ofDSTB-related cost data 1972 2005 W2768092287.pdf 10 30 separator 0.99542594 ¶ 2005 2007 W2768092287.pdf 10 31 text 0.99950343 "Conducted inBrazil, Colombia, Ecuador, Ghana, Mexico, Tanzania, and Yemen between 2006 and 2012, survey sample sizes ranged from 94to320patients with active DSTBdisease (Table 1).Surveys collected data onDSTB-related costs incurred pre- and during-treat- ment, except inBrazil [33], Colombia [62], and Tanzania [63], where they only collected data during-treatment (Table 1).Surveys collected both direct and indirect cost data, except inMexico [64] where nodata was collected characterising indirect costs (Table 1).Incoun- tries where data was collected, methods forestimating indirect costs varied in2ways: 1) reported time losttravelling and waiting toreceive TBcare was multiplied bypatients' reported income [33,65]; or2)reported time losttravelling and waiting toreceive TBcare was multiplied byanestimate ofnational average income (gross national income percapita orofficial wage rate) [33,62,63,66]. InEcuador [66], data was collected onadditional costs described inthepublication asreferring toaloans, paying foradditional help and other impacts throughout thecourse ofTBillness.o The ambiguity ofthis cost category meant that itcould notbeclassified aseither direct orindirect costs and was thus reported asits own subcategory. Reported mean DSTB-related total costs forthecomplete TBillness ran- gedfrom $387 to$2,382 (Table 1).After imputing missing TB-related cost components in Brazil, Colombia, Mexico and Tanzania, estimated mean DSTB-related total costs ranged from $774 (95% CI:$618±$930) to$5,954 (95% CI:$4,997±$6,911), Table 1." 2007 3591 W2768092287.pdf 10 32 separator 0.99199486 ¶ 3591 3593 W2768092287.pdf 10 33 title 0.96009624 Modelling cash transfer 'spotential toprevent TBcatastrophi ccosts 3593 3660 W2768092287.pdf 10 34 separator 0.74291325 ¶ 3660 3662 W2768092287.pdf 10 35 paratext 0.98755366 PLOS Medicine |https://doi.or g/10.1371/ journal.pmed.1 002418 November 7,2017 11/28 3662 3747 W2768092287.pdf 10 0 paratext 0.89607203 GRIFFITH AND LUO 9o f3 1 0 24 W2950110455.pdf 8 1 separator 0.987381 ¶ 24 26 W2950110455.pdf 8 2 text 0.9461018 for each m=1,...,M. Similarly, Equation 19 becomes 26 75 W2950110455.pdf 8 3 separator 0.70801663 ¶ 75 77 W2950110455.pdf 8 4 math 0.9361842 "M∑ l=1( ∫Uφl(X)φm(X)dX) Gl(t)=−∫UPe h(X,t)∇ Xφm(X)dX, (36)" 77 144 W2950110455.pdf 8 5 separator 0.73440254 ¶ 144 146 W2950110455.pdf 8 6 text 0.9721616 for each m=1,...,M. In practice, these integrals are approximated via Gaussian quadrature. 146 235 W2950110455.pdf 8 7 separator 0.9947938 ¶ 235 237 W2950110455.pdf 8 8 title 0.99357384 3.2.2 Immersed rigid structures 237 269 W2950110455.pdf 8 9 separator 0.99674463 ¶ 269 271 W2950110455.pdf 8 10 text 0.9969878 For a fixed, rigid immersed structure, we directly evaluate the discretized Lagrangian penalty force Fh(X,t)via 271 383 W2950110455.pdf 8 11 separator 0.6913309 ¶ 383 385 W2950110455.pdf 8 12 math 0.8832522 "Fh(X,t)=κ( χh(X,0)−χh(X,t)) −η∂χh ∂t(X,t). (37)" 385 439 W2950110455.pdf 8 13 separator 0.8306382 ¶ 439 441 W2950110455.pdf 8 14 text 0.99667656 Because χh(X,t)andFh(X,t)are defined in terms of the same basis functions, Fh(X,t)is given by 441 535 W2950110455.pdf 8 15 separator 0.57480145 ¶ 535 537 W2950110455.pdf 8 16 math 0.8266837 "Fh(X,t)=∑ lFl(t)φl(X) (38) " 537 567 W2950110455.pdf 8 17 separator 0.40179762 ¶ 567 568 W2950110455.pdf 8 18 math 0.8481498 "in which Fl(t)=κ(χl(0)−χl(t))−ηdχl dt(t). (39)" 568 619 W2950110455.pdf 8 19 separator 0.9947746 ¶ 619 621 W2950110455.pdf 8 20 title 0.99319154 3.2.3 Lagrangian inner products 621 653 W2950110455.pdf 8 21 separator 0.99654305 ¶ 653 655 W2950110455.pdf 8 22 text 0.9578972 "Letting[F]denote the vector of nodal coefficients of Fh, we write Equation 35 as [][F]=[ B], (40) in which []is the mass matrix that has entries of the form ∫Uφl(X)φm(X)dX. Equation 36 may be rewritten similarly." 655 874 W2950110455.pdf 8 23 separator 0.88643885 ¶ 874 876 W2950110455.pdf 8 24 text 0.99792445 The mass matrix []can also be used to evaluate the L2inner product of Lagrangian functions on U. In particular, for any 876 997 W2950110455.pdf 8 25 separator 0.5439234 ¶ 997 999 W2950110455.pdf 8 26 math 0.8208028 "Uh(X,t)=∑ lUl(t)φl(X)andVh(X,t)=∑ lVl(t)φl(s), (Uh,Vh)X=[U]T[][V]. (41)" 999 1078 W2950110455.pdf 8 27 separator 0.95192665 ¶ 1078 1080 W2950110455.pdf 8 28 text 0.9951696 Different choices of mass matrices (eg, lumped mass matrices) induce different discrete inner products on U. 1080 1189 W2950110455.pdf 8 29 separator 0.5916923 ¶ 1189 1191 W2950110455.pdf 8 30 text 0.9902448 "To simplify notation, in the remainder of this paper, we drop the subscript hfrom our numerical approximations to the Lagrangian variables." 1191 1333 W2950110455.pdf 8 31 separator 0.9962362 ¶ 1333 1335 W2950110455.pdf 8 32 title 0.9941398 3.3 Lagrangian-Eulerian interaction 1335 1371 W2950110455.pdf 8 33 separator 0.9962945 ¶ 1371 1373 W2950110455.pdf 8 34 text 0.9905837 "We next describe Lagrangian-Eulerian coupling operators that take advantage of the kinematic information encoded in the FEapproximation to the deformation of the immersed structure. As in the conventional IB method, we approximate the singular delta function kernel appearing in the Lagrangian-Eulerian interaction equations by a smoothed d-dimensional Dirac delta functionδ h(x)that is of the tensor-product form δh(x)=∏d i=1δh(xi). Except where otherwise noted, in this work, we take the one-dimensional smoothed delta function δh(x)to be the four-point delta function of Peskin.3" 1373 1966 W2950110455.pdf 8 35 separator 0.9843099 ¶ 1966 1968 W2950110455.pdf 8 36 text 0.9787148 "To compute an approximation to f=( f1,f2)on the Cartesian grid, we construct for each element Ue∈ha Gaussian quadrature rule with Nequadrature points Xe Q∈Ueand weights ωe Q,Q=1,...,Ne. We then compute f1and f2on the edges of the Cartesian grid cells via" 1968 2230 W2950110455.pdf 8 0 paratext 0.9897723 | 669 4 10 W2905303427.pdf 5 1 separator 0.93637085 ¶ 10 12 W2905303427.pdf 5 2 title 0.9868689 REISCH and SCHMI d 12 31 W2905303427.pdf 5 3 separator 0.98618823 ¶ 31 33 W2905303427.pdf 5 4 text 0.9995732 "genetic diversity is higher in populations from grasslands which were located close to other grasslands in 1830 and which exhibit higher levels of connectivity today. In the fragmented dry grass ‐ lands we analyzed here, SD is therefore mainly affected by the present land use, whereas GD is basically driven by historical and present landscape configuration." 33 398 W2905303427.pdf 5 5 separator 0.9607191 ¶ 398 400 W2905303427.pdf 5 6 text 0.99971956 "A positive correlation of SD and GD would indicate that the mechanisms driving species and genetic diversity are effective si ‐ multaneously at both levels of biodiversity. The absence of such a correlation, as observed here, implies in contrast that different mechanisms are effective at the two organizational levels. It has al ‐ ready been demonstrated that a lack of correlation between SD and GD may especially occur when the effects derived from the equi ‐ librium theory of island biogeography on SD and GD are postponed temporarily (Lamy et al., 2013). Delayed response of GD on fragmen ‐ tation has been already reported for some species (Münzbergová et al., 2013; Vandepitte, Jacquemyn, Roldán‐Ruiz, & Honnay, 2007) and can most likely be connected to the persistence and the life span of the analyzed perennial plant species. Simulation experiments revealed that, under conditions of limited dispersal, historical land ‐ scape structure might be still detectable after more than 100 gen ‐ erations (Landguth et al., 2010). The observed lack of correlation between SD and GD may therefore indicate that the study system has not yet reached equilibrium (Lamy et al., 2013) and that a posi ‐ tive SGDC does not before the footprint of the historical landscape configuration is lost." 400 1708 W2905303427.pdf 5 7 separator 0.98789644 ¶ 1708 1710 W2905303427.pdf 5 8 text 0.999747 "Moreover, the positive relationship between SD and GD may be concealed by different levels of habitat heterogeneity. Dry grasslands are semi‐natural ecosystems, which originated from grazing mainly by sheep (Poschlod & Wallis De Vries, 2002). It has already been shown that land use by grazing increases hab ‐ itat heterogeneity (Marion, Bonis, & Bouzillé, 2010; Moinardeau, Mesléard, & Dutoit, 2016). In contrast, abandonment and the joint lack of grazing lead to a dominance of grasses and decrease hab ‐ itat heterogeneity (Bobbink & Willems, 1987). Increasing habitat heterogeneity decreases the area available for the component species of a plant community and reduces, therefore, the size of the species’ populations. Since population size is positively cor ‐ related with GD (Leimu, Mutikainen, Koricheva, & Fischer, 2006), increased habitat heterogeneity may, therefore, lead to increasing SD while GD decreases simultaneously (Kahilainen et al., 2014). In a study on North American grasslands, it has recently been demonstrated that SD is positively linked to resource heteroge ‐ neity, whereas GD did not respond to this factor (Avolino & Smith, 2013). This supports our assumption that land use‐dependent levels of heterogeneity may contribute to the lack of correlation between SD and GD we observed here." 1710 3039 W2905303427.pdf 5 9 separator 0.9966175 ¶ 3039 3041 W2905303427.pdf 5 10 title 0.9774872 4 | CONCLUSIONS 3041 3058 W2905303427.pdf 5 11 separator 0.9969497 ¶ 3058 3060 W2905303427.pdf 5 12 text 0.99977183 "The conservation of biodiversity, as defined by the Convention on Biodiversity (CBD; www.cbd.int/convention/text/), requires the protection of variation at the level of ecosystems, species, and genes. Whereas ecosystems and species have been in the focus of conservation for a long time, much less attention has been paid to intraspecific genetic variation. From the mostly positive relation ‐ ship between SD and GD, it has been derived that the protection of species may be attended by the conservation of genetic varia ‐ tion due to the parallel response of the two levels of biodiversity to environmental conditions (Kahilainen et al., 2014). It has even been suggested that genetic variation of common species predicts" 3060 3788 W2905303427.pdf 5 13 caption 0.9954682 "FIGURE 2 Relationship between species diversity (SD) and mean genetic diversity (GDm) for all species (a) and the grassland specialists (b). Correlations were not significant ( p > 0.05)" 3788 3981 W2905303427.pdf 5 14 separator 0.99576247 ¶ 3981 3983 W2905303427.pdf 5 0 paratext 0.9713849 Braz Dent J 17(3) 2006SEM and profilometer study of sharp stones 237 Braz Dent J (2006) 17(3): 237-242 0 102 W1972457296.pdf 0 1 separator 0.92335176 ¶ 102 104 W1972457296.pdf 0 2 title 0.9855517 Scanning Electron Microscopic and Profilometric 104 152 W1972457296.pdf 0 3 separator 0.65945005 152 153 W1972457296.pdf 0 4 title 0.93675506 ¶ Study of Different Sharpening Stones 153 191 W1972457296.pdf 0 5 separator 0.98125255 ¶ 191 193 W1972457296.pdf 0 6 contact 0.98425865 "Roberto Antonio ANDRADE ACEVEDO1 Ana Karina Veloso CARDOZO2 José Eduardo César SAMPAIO3 1Department of Periodontology, School of Dentistry of Araraquara, State University of São Paulo, Araraquara, SP, Brazil 2Department of Periodontology, School of Dentistry, Federal University of Bahia, Salvador, BA, Brazil 3Department of Diagnosis and Surgery, School of Dentistry of Araraquara, State University of São Paulo, Araraquara, SP, Brazil" 193 642 W1972457296.pdf 0 7 separator 0.9951402 ¶ 642 644 W1972457296.pdf 0 8 text 0.99965626 "Scaling and root planing contribute to the recovery of periodontal health. All periodontal instruments loose their fine cutting angle after use. To maintain this angle, correct sharpening is required using specifically designed stones. The characteristics of sharpeni ng stones can be compared to the blade of the instruments and also transported to root surface during instrumentation. Root smoothness is related to the quality of the blade. Therefore, the purpose of this study was to evaluate the characteristics of 9 sharpening stones by scanning electron microscopic and profilometric analyses. Ceramic and Neumar stones were very fine and both may be recommended to mainta in the sharpness of the instruments. Arkansas, Thompson and CE stones presented greater roughness with very regular and round particles, and are suitable for maintenance of the cutting angle. In addition, these stones may be indicated for the routine sh arpening of the instruments that are partly dull. Oxide Aluminum, Carborundum and JON stones were the coarsest with large irregular particl es and may be indicated for initial sharpening of totally dull instruments with completion of sharpening with finer stones." 644 1860 W1972457296.pdf 0 9 separator 0.97268534 ¶ 1860 1862 W1972457296.pdf 0 10 text 0.9411494 Key Words: scanning electron microscopy, scaling, dental instruments, roughness, sharpening stones. 1862 1962 W1972457296.pdf 0 11 separator 0.9931375 ¶ 1962 1964 W1972457296.pdf 0 12 contact 0.99535614 "Correspondence: Prof. Dr. José Eduardo César Sampaio, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Arara quara, UNESP, Rua Humaitá, 1680, 14801-903 Araraquara, SP, Brasil. Tel: +55-16-3301-6369. Fax: +55-16-3301-6369. e-mail: jsampaio@foar.unesp.brISSN 0103-6440" 1964 2254 W1972457296.pdf 0 13 separator 0.9955263 ¶ 2254 2256 W1972457296.pdf 0 14 title 0.98954886 INTRODUCTION 2256 2269 W1972457296.pdf 0 15 separator 0.995799 ¶ 2269 2271 W1972457296.pdf 0 16 text 0.99970627 "Dental biofilm is the main etiologic factor for development of periodontal disease (1). Periodontaltherapy is based on not only the mechanical eliminationof supra- and subgingival bacterial biofilm but also ofcalculi, which can harbor microorganisms (2). Scaling and root planing (SRP) are efficient to carry out these objectives and to promote periodontal health (3). SRPshould be done with well-sharpened instruments be-cause the smoothness of root surface is directly relatedto the quality of the instrument cutting edge." 2271 2802 W1972457296.pdf 0 17 separator 0.5535773 ¶ 2802 2804 W1972457296.pdf 0 18 text 0.9995828 "After some strokes, all periodontal instruments loose their fine cutting edge and are less efficient for the removal of bacterial plaque, calculus and contaminatedcementum (4-6). A dull curette reduces the tactilesensitivity, increases the pressure required as well asprofessional fatigue and working time (4). Therefore, the grinding of one or two instrument surfaces withspecifically designed stones (natural or artificial, lubri- cated or not, fine or coarse) is necessary." 2804 3289 W1972457296.pdf 0 19 separator 0.6503396 ¶ 3289 3291 W1972457296.pdf 0 20 text 0.9995748 "It is very important to know sharpening tech- niques (7), as well as the type of stone that offers moreadvantages in terms of cutting angle fineness. Coarserstones have large abrasive crystals that cut quickly. Finestones have small particles and cutting speed is slower, proper for finishing and producing a delicate and smooth cutting edge." 3291 3640 W1972457296.pdf 0 21 separator 0.8399241 ¶ 3640 3642 W1972457296.pdf 0 22 text 0.99962926 "Considering that the characteristics of the cut- ting edge can be transported to the root surface duringSRP procedures (8,9), creating irregularities similar tothe sharpening stone employed, the purpose of this study was to evaluate 9 different types of sharpening stones, using scanning electron microscopy (SEM) and" 3642 3966 W1972457296.pdf 0 0 paratext 0.951024 "Como citar este artigo Robazzi MLCC, Suazo SVV. Retraction of Nursing scientific publications. Rev. Latino-Am. Enfermagem. 2023;31:e3921. [cited mês ano dia]; Available from: URL. https://doi.org/10.1590/1518-8345.0000.3921Rev. Latino-Am. Enfermagem 2023;31:e3922 DOI: 10.1590/1518-8345.0000.3922 www.eerp.usp.br/rlae" 0 335 W4366088474.pdf 0 1 separator 0.99253786 ¶ 335 337 W4366088474.pdf 0 2 title 0.99151635 A retratação de publicações científicas da enfermagem 337 391 W4366088474.pdf 0 3 separator 0.9790857 ¶ 391 393 W4366088474.pdf 0 4 contact 0.9945705 "Maria Lucia do Carmo Cruz Robazzi1 http://orcid.org/0000-0003-2364-5787 Sandra Valenzuela Suazo2 http://orcid.org/0000-0002-1308-4835Editorial" 393 545 W4366088474.pdf 0 5 separator 0.99222165 ¶ 545 547 W4366088474.pdf 0 6 text 0.9994084 "A palavra retratação é derivada do idioma latim retracto-are - tocar novamente, retomar, corrigir, retirar; tem o sentido de retirar o que se disse, dar o dito por não dito, desdizer, desculpar-se(1), reconhecer o erro(2). Em muitas situações há necessidade de ter-se uma retratação e, inclusive, no âmbito da ciência envolvendo, por exemplo, as publicações. Retratar textos científicos publicados não é fato novo; ocorre há anos no ambiente acadêmico/científico." 547 1027 W4366088474.pdf 0 7 separator 0.9447453 ¶ 1028 1030 W4366088474.pdf 0 8 text 0.99947155 "A publicação retratada configura-se como um artigo ou livro retratado no todo ou em parte, por um autor ou autores ou um representante autorizado. O autor identifica uma citação previamente publicada e retrata-a por meio de uma publicação formal, ou dele mesmo, ou do editor ou outro agente autorizado(3). Já a retratação de uma publicação trata-se de uma declaração publicada por um ou mais autores de um artigo ou um livro, retirando ou confrontando sua participação na realização da pesquisa ou registro escrito dos resultados de seu estudo(4)." 1030 1596 W4366088474.pdf 0 9 separator 0.9417379 ¶ 1597 1599 W4366088474.pdf 0 10 text 0.9996089 "As retratações de publicação acontecem quando as descobertas científicas não são mais consideradas confiáveis, decorrentes de má conduta ou erro científico, plágio de estudos publicados anteriormente ou violação de diretrizes éticas(5). Quando há suspeita e/ou confirmação de condutas antiéticas como falsidade de dados, falta de consentimento dos participantes, problemas metodológicos, dados clonados e plágio, entre outros, deve acontecer a retratação do que foi publicado. Mas ocorre, também, quando o artigo é falacioso e não apresenta arcabouço teórico para as afirmações feitas e quando há viés, conflito de interesses e dados tendenciosos(6)." 1599 2268 W4366088474.pdf 0 11 separator 0.8998965 ¶ 2269 2271 W4366088474.pdf 0 12 text 0.9996151 "A revisão por pares solicitada pelos editores, na maioria das vezes, contribui para a clareza e qualidade do artigo submetido a um periódico, detectando equívocos e interpretações errôneas(7). Entretanto, em algumas avaliações, percebe-se a devolutiva de pareceres frágeis e que pouco auxiliam para a melhoria da qualidade do artigo que está sendo avaliado." 2271 2638 W4366088474.pdf 0 13 separator 0.7564088 ¶ 2638 2640 W4366088474.pdf 0 14 text 0.9996359 "Identifica-se, então, que essa prática está se tornando mais comum, advinda da pressão pelo cumprimento de prazos para publicação e do não discernimento editorial em identificar, previamente, problemas com os textos submetidos, aprovados e publicados, como os casos de plágios e de falsificação de dados de pesquisa(8)." 2640 2966 W4366088474.pdf 0 15 separator 0.9959954 ¶ 2967 2969 W4366088474.pdf 0 16 contact 0.95012635 "1 Universidade de São Paulo, Escola de Enfermagem de Ribeirão Preto, Centro Colaborador da OPAS/OMS para o Desenvolvimento da Pesquisa em Enfermagem, Ribeirão Preto, SP, Brasil." 2969 3150 W4366088474.pdf 0 17 separator 0.94356054 ¶ 3150 3152 W4366088474.pdf 0 18 bibliography 0.7041898 2 Universidad de Concepción. Facultad de Enfermería, Departamento del Adulto y Adulto Mayor, Concepción, Chile.2023;31: e3921 3152 3278 W4366088474.pdf 0 19 separator 0.85336787 ¶ 3278 3280 W4366088474.pdf 0 20 paratext 0.9772237 10.1590/1518-8345.0000.3921 3280 3308 W4366088474.pdf 0 21 separator 0.9966676 ¶ 3308 3310 W4366088474.pdf 0 0 paratext 0.9880783 www.nature.com/scientificreports/3 0 34 W2753359558.pdf 2 1 separator 0.87720764 ¶ 34 36 W2753359558.pdf 2 2 paratext 0.908397 Scientific RepoRts | 7: 10523 | DOI:10.1038/s41598-017-10868-z 36 102 W2753359558.pdf 2 3 text 0.99799013 "were investigated by 2′ ,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) staining. As shown in Fig. 1d, the ROS levels reflected by fluorescence intensity in the ALC (60 mM) or KET (100 μM) alone treatment groups were significantly increased compared with that of the control group (p < 0.01). ALC (60 mM) and KET (100 μM) co-exposure for 24 h further increased the levels of ROS compared with the ALC or KET alone treatment groups (p < 0.05). Furthermore, transmission electron microscopy was used to study the ultrastructural changes after treatment with ALC and/or KET. As shown in Fig. 1e, the nuclear membrane was smooth with normal chroma- tin, and the mitochondrial membrane was smooth with normal mitochondrial cristae in the control group. ALC (60 mM) or KET (100 μM) alone treatment for 24 h led to chromatin margination and decreased mitochondrial cristae, which were more obvious when cells were co-exposed with ALC (60 mM) and KET (100 μM) for 24 h." 102 1092 W2753359558.pdf 2 4 separator 0.9900868 ¶ 1092 1094 W2753359558.pdf 2 5 text 0.9994061 "KET-induced cell viability decrease in primary cultured neuronal cells is potentiated by ALC. Primary cultured neuronal cells of the cortex were used to further test the effect of ALC on KET-induced neurotoxicity. As shown in Fig. 2, ALC (10–70 mM, Fig. 2a) or KET (10–300 μM, Fig. 2b) treatment for 24 h dose-dependently decreased the cell viability of neurons. Based on the above data, further experiments were conducted to study the effect of ALC (10 mM) and KET (10 μM) co-exposure for 24 h on the cell viability of pri- mary cultured neuronal cells. The different doses were used between PC12 cells and primary cultured neuronal cells because different cell types have various sensitivities to ALC or KET. As shown in Fig. 2c, ALC (10 mM) and KET (10 μM) co-treatment for 24 h significantly decreased neuronal viability compared with ALC or KET treatment alone at the same dose (p < 0.05). Figure 2d shows the morphological changes using β Ш-tubulin and 4′, 6-diamidino-2-phenylindole (DAPI) staining. The neurons in the control group grew well with normal neu- ronal soma and synapses. ALC (10 mM) or KET (10 μM) treatment for 24 h decreased the number of neurons and disrupted neuronal soma and synapses, which can be found severer with co-exposure of ALC (10 mM) and KET (10 μM) for 24 h to the cells." 1094 2444 W2753359558.pdf 2 6 separator 0.9927268 ¶ 2444 2446 W2753359558.pdf 2 7 text 0.9573891 ALC potentiates KET-induced decrease in cell viability and the involvement of AMPA/KA receptors. 2446 2543 W2753359558.pdf 2 8 separator 0.9079213 ¶ 2546 2548 W2753359558.pdf 2 9 text 0.9994414 "The AMPA/KA receptor inhibitor CNQX was used to confirm if AMPA/KA receptors are involved in the cytotox - icity of ALC and KET. The dose selection of CNQX was based on the reference24 and our preliminary experiments." 2548 2768 W2753359558.pdf 2 10 separator 0.9920818 ¶ 2769 2771 W2753359558.pdf 2 11 caption 0.99608594 "Figure 2. Cell viability assessed by MTT assay and morphological change assessed by immunofluorescence staining in primary cultured cortical neurons. (a) ALC (10–70 mM) dose-dependently decreased the cell viability of neurons. (b) KET (10–300 μM) dose-dependently decreased the cell viability of neurons. (c) ALC (10 mM) potentiated KET (10 μM)-induced cell viability decrease of neurons. (d) ALC (10 mM) potentiated KET (10 μM)-induced morphological change assessed by immunofluorescence staining using βШ-tubulin and DAPI. Scale bar = 20 μm. *p < 0.05, **p < 0.01 compared with the control group. #p < 0.05 compared with the group treated with ALC and KET." 2771 3448 W2753359558.pdf 2 0 paratext 0.9886973 31 Rev Saúde Pública 2009;43(Supl. 1):29-35 0 43 W2150302329.pdf 2 1 separator 0.9732784 ¶ 43 45 W2150302329.pdf 2 2 paratext 0.53677034 a Wetzel C. 45 57 W2150302329.pdf 2 3 bibliography 0.6518576 "Avaliação de serviços de saúde mental: a construção de um processo participativo. [tese de doutorado]. Ribeirão Pret o: Escola de Enfermagem de Ribeirão Preto da" 57 222 W2150302329.pdf 2 4 paratext 0.5447375 USP; 2005.saúde mental prioriza no campo da avaliação um olhar 222 285 W2150302329.pdf 2 5 bibliography 0.4256049 286 287 W2150302329.pdf 2 6 paratext 0.48645014 ¶ sistemático e cientí fi co sobre os serviços constituídos 287 345 W2150302329.pdf 2 7 bibliography 0.3795108 346 347 W2150302329.pdf 2 8 paratext 0.46969467 ¶ no processo de Reforma Psiquiátrica. 347 385 W2150302329.pdf 2 9 separator 0.9857007 ¶ 385 387 W2150302329.pdf 2 10 text 0.9718854 "O presente artigo teve por objetivo avaliar a satisfação dos usuários com o atendimento nos centros de atenção psicossocial." 387 515 W2150302329.pdf 2 11 separator 0.9948105 ¶ 515 517 W2150302329.pdf 2 12 title 0.98730445 MÉTODOS 517 525 W2150302329.pdf 2 13 separator 0.99360305 ¶ 525 527 W2150302329.pdf 2 14 text 0.9995278 "O estudo foi realizado com parte dos dados de uma pesquisa mais ampla sobre avaliação dos centros de atenção psicossocial (CAPS) da região Sul do Brasil. Foram avaliados em 2006 os CAPS dos estados do Paraná, Santa Catarina e Rio Grande do Sul. Para realização da pesquisa foram utilizados os métodos quantitativo e qualitativo." 527 859 W2150302329.pdf 2 15 separator 0.5861423 ¶ 859 861 W2150302329.pdf 2 16 text 0.99730045 "A avaliação quantitativa acerca da qualidade da atenção pode orientar a exploração dirigida às estratégias mais efetivas em um processo de reestruturação dos serviços." 861 1032 W2150302329.pdf 2 17 separator 0.8062329 ¶ 1032 1034 W2150302329.pdf 2 18 text 0.979001 "7-9 O estudo constituiu-se de três sub-estudos complementares: descrição das características da estrutura das unidades de atendimento; descrição do processo de trabalho e organização da atenção em saúde dos CAPS da região Sul; avaliação dos resultados da atenção em saúde mental." 1034 1317 W2150302329.pdf 2 19 separator 0.9434466 ¶ 1317 1319 W2150302329.pdf 2 20 text 0.99637437 "A amostra estudada incluiu coordenadores, trabalhadores, familiares e usuários de 30 centros de atenção psicosso-cial (CAPS I e CAPS II), distribuídos nos três estados, conforme a concentração de serviços por estado." 1319 1539 W2150302329.pdf 2 21 separator 0.9347777 ¶ 1539 1541 W2150302329.pdf 2 22 text 0.9994866 "No estado do Paraná, foram selecionados três muni- cípios: Cianorte (CAPS I) e Curitiba, Francisco Beltrão (ambos CAPS II). Em Santa Catarina, foram selecionados nove municípios: Xaxim, Timbó, Rio do Sul, Orleans e Içara (CAPS I), e Caçador, Joinville, Florianópolis e Criciúma (CAPS II). No Rio Grande do Sul, foram escolhidos nove CAPS I: Santo Ângelo, Panambi, Santiago, Bento Gonçalves, Triunfo, Parobé, São Sepé, Santana do Livramento, Capão do Leão; e nove CAPS II – Carazinho, Passo Fundo, Alegrete, Bagé, Santa Maria, Santa Cruz do Sul, Rio Grande, Esteio, e Porto Alegre." 1541 2130 W2150302329.pdf 2 23 separator 0.9680284 ¶ 2130 2132 W2150302329.pdf 2 24 text 0.99402076 "Os usuários e familiares sorteados para a amostra foram entrevistados nos CAPS e nos domicílios." 2132 2232 W2150302329.pdf 2 25 separator 0.89611113 ¶ 2232 2234 W2150302329.pdf 2 26 text 0.9950383 "Na perspectiva de aproximação com um efeito possível na mudança do modelo assistencial, o cálculo da amostra foi orientado pelos seguintes desfechos: satisfação do usuário; padrão de saúde e autonomia, inserção e cidadania. Para o cálculo da amostra foi utilizado um valor de erro alfa igual a 5% e um poder de 95% no software Epi Info 6.04. De acordo com as diferentes medidas e indicadores de variabilidade encontrados na literatura, foram utilizados para se obter valores com menor possibilidade de erro, mesmo frente a um incipiente acúmulo de investigações sobre esta perspectiva de atenção em saúde mental. Ao maior valor calculado foi acrescido 30% para controle de fator de confusão e perdas A amostra foi estruturada considerando as diferenças no nível de complexidade entre os três modelos de atenção previstos para os CAPS, totalizando 1.200 usuários e familiares." 2234 3119 W2150302329.pdf 2 27 separator 0.979426 ¶ 3119 3121 W2150302329.pdf 2 28 text 0.9769135 "Considerando a concentração dos diferentes centros por estado e aspectos logísticos, foram de fi nidos para entrevista 40 usuários e 40 familiares em cada centro, em 30 CAPS. Entre os 40 usuários de fi niu-se uma divisão propor- cional conforme o nível de complexidade de atenção: em 12 intensivos; 12 não-intensivos e 16 semi-intensivos." 3121 3468 W2150302329.pdf 2 29 separator 0.88894725 ¶ 3468 3470 W2150302329.pdf 2 30 text 0.9995227 "Os questionários utilizados foram construídos e vali- dados a partir de indicações da legislação especí fi ca da atenção em saúde mental. Os instrumentos foram previa-mente testados em serviços que não integraram a amostra estudada. A satisfação do usuário foi avaliada pela Escala Brasileira de Avaliação da Satisfação (SATIS-BR). Esta escala, elaborada pela Divisão de Saúde Mental da OMS, foi validada no Brasil e utiliza uma escala tipo Likert de cinco pontos, na qual o cinco representa uma maior satisfação e o um, maior insatisfação." 3470 4015 W2150302329.pdf 2 31 separator 0.95887274 ¶ 4015 4017 W2150302329.pdf 2 32 text 0.7272872 3-5 4017 4021 W2150302329.pdf 2 33 separator 0.95432806 ¶ 4021 4023 W2150302329.pdf 2 34 text 0.9948796 "Os dados foram colhidos por 14 entrevistadores previamente treinados e sob coordenação de dois supervisores. Os questionários aplicados foram codi fi cados pelo entrevistador, compondo banco de dados no software Epi Info, com dupla digitação independente. Após comparação dos dois arquivos, foram corrigidos os erros de amplitude e consistência. As análises foram realizadas no software Stata." 4023 4426 W2150302329.pdf 2 35 separator 0.91557384 ¶ 4426 4428 W2150302329.pdf 2 36 text 0.99914944 "O controle de qualidade foi realizado na aplicação dos instrumentos de coleta: por meio de checagem de cada entrevistador ao fi nal da entrevista; na revisão realizada pelos supervisores ao receber o questionário; na repli-cação de 5% das entrevistas realizadas." 4428 4696 W2150302329.pdf 2 37 separator 0.9427042 ¶ 4696 4698 W2150302329.pdf 2 38 text 0.9995197 "Para o estudo qualitativo, utilizou-se da avaliação de quarta geração – construtivista, responsiva e com abor- dagem hermenêutico-dialética. A avaliação de quarta geração, desenvolvida por Guba & Lincoln 10-12 e adap- tada por Wetzel (2005),a foi norteadora do processo teórico-metodológico da pesquisa. Os instrumentos de coleta de dados foram entrevistas com trabalhadores, usuários e familiares (de fi nidos como grupos de inte- resse para compor o círculo hermenêutico-dialético) e observação de campo (con fi gurando-se numa etno- grafi a prévia)." 4698 5268 W2150302329.pdf 2 0 paratext 0.9794674 "1 Vol.:(0123456789) Scientific Reports | (2021) 11:4511 | https://doi.org/10.1038/s41598-021-83904-8 www.nature.com/scientificreports" 0 147 W3112005171.pdf 0 1 title 0.97669506 "Behavioral effects of continuous theta‐burst stimulation in macaque parietal cortex" 147 236 W3112005171.pdf 0 2 separator 0.97393215 ¶ 236 238 W3112005171.pdf 0 3 bibliography 0.70767516 Lara Merken1,3, Marco Davare2, Peter Janssen1,3 & Maria C. Romero1,3* 238 308 W3112005171.pdf 0 4 separator 0.99397385 ¶ 308 310 W3112005171.pdf 0 5 text 0.9996235 "The neural mechanisms underlying the effects of continuous Theta‐Burst Stimulation (cTBS) in humans are poorly understood. Animal studies can clarify the effects of cTBS on individual neurons, but behavioral evidence is necessary to demonstrate the validity of the animal model. We investigated the behavioral effect of cTBS applied over parietal cortex in rhesus monkeys performing a visually‐ guided grasping task with two differently sized objects, which required either a power grip or a pad‐ to‐side grip. We used Fitts’ law, predicting shorter grasping times (GT) for large compared to small objects, to investigate cTBS effects on two different grip types. cTBS induced long‐lasting object ‐ specific and dose‐dependent changes in GT that remained present for up to two hours. High‐intensity cTBS increased GTs for a power grip, but shortened GTs for a pad‐to‐side grip. Thus, high‐intensity stimulation strongly reduced the natural GT difference between objects (i.e. the Fitts’ law effect). In contrast, low‐intensity cTBS induced the opposite effects on GT. Modifying the coil orientation from the standard 45‐degree to a 30‐degree angle induced opposite cTBS effects on GT. These findings represent behavioral evidence for the validity of the nonhuman primate model to study the neural underpinnings of non‐invasive brain stimulation." 310 1692 W3112005171.pdf 0 6 separator 0.99070036 ¶ 1692 1694 W3112005171.pdf 0 7 text 0.99973655 "Transcranial Magnetic Stimulation (TMS) is widely used to modulate brain activity in healthy volunteers and patients1–7. While a single TMS pulse can activate neurons (and induce a muscle twitch when applied over the primary motor cortex), repetitive TMS protocols can either temporarily increase or decrease neuronal excit- ability. Huang et al.8 described a reduction in the Motor Evoked Potential (MEP) after continuous Theta-Burst Stimulation (cTBS) over primary motor cortex, in which 50 Hz triplets of TMS pulses were administered every 200 ms (5 Hz) for 20 to 40 s. Since this seminal study, numerous publications have used cTBS as a tool to reduce cortical excitability and further investigate cTBS behavioral effects in humans9–13." 1694 2454 W3112005171.pdf 0 8 separator 0.9832412 ¶ 2454 2456 W3112005171.pdf 0 9 text 0.9997529 "Despite a vast body of TMS research, very little is known about the neuronal effects of this noninvasive neu- romodulation technique, which is partially due to the limited number of experimental models and tools explored until recent years. Previous TMS research has been mainly performed in combination with functional Magnetic Resonance Imaging (fMRI) and electroencephalography (EEG) in humans. Because these two techniques pro- vide indirect measurements of neural activity, an animal model in which researchers apply TMS during invasive extracellular recordings was necessary. Mueller et al.14 recorded action potentials in awake monkeys shortly after the TMS burst. We recently charted the effect of single-pulse TMS on individual neurons in parietal cortex while monkeys were performing a grasping task15. TMS evoked a short burst of activity in single neurons, but the volume of cortex in which it induced a significant response was surprisingly small (2 by 2 by 2 mm). Moreover, the activation caused by TMS was frequently followed by reduced activity in task-related neurons, which was paralleled by a significant increase in grasping time (GT)." 2456 3641 W3112005171.pdf 0 10 separator 0.97952104 ¶ 3641 3643 W3112005171.pdf 0 11 text 0.9997537 "The nonhuman primate (NHP) model therefore provides significant advantages compared to other animal models for the study of TMS effects on neural activity. The presence of sulci and gyri—similar to the human brain and unlike the brains of rodents—determines the current spread16 and thereby the size of the activated area. In addition, using NHPs we can test TMS effects in much more controlled conditions, which are more difficult to achieve in human volunteers. For example, the TMS coil can be rigidly positioned on the skull, at exactly the same location from day to day and with the same angle15, by anchoring it to a pair of rods previously implanted on the head of the animal, avoiding several potential sources of variability such as subtle differences in coil positioning. More importantly, NHPs can perform a number of motor tasks, which allows studying the effects of TMS on both neurons and behavior, so that the results can be compared with studies in humans." 3643 4642 W3112005171.pdf 0 12 paratext 0.91057444 Similar OPEN 4642 4655 W3112005171.pdf 0 13 separator 0.9443698 ¶ 4655 4657 W3112005171.pdf 0 14 contact 0.99357015 "1Laboratory for Neuro- and Psychophysiology, KU Leuven, 3000 Leuven, Belgium. 2College of Health and Life Sciences and Centre for Cognitive Neuroscience, Brunel University London, UxBridge UB8 3PN, UK. 3Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. *email: mela.romeropita@kuleuven.be" 4657 4959 W3112005171.pdf 0 0 paratext 0.9784622 Page 14 of 14 Austin and van Buuren BMC Medical Research Methodology (2022) 22:196 0 92 W4285727872.pdf 13 1 separator 0.9918145 ¶ 93 95 W4285727872.pdf 13 2 text 0.999154 "and epidemiological applications. A second limitation was that in all our simulations we fit a correctly specified imputation model. We thought that it was important to do so, as our intent was to examine the performance of MI in settings with a high prevalence of missing data. To do so, it is important to consider the ideal setting where everything is done correctly, and the only factor that varies is the proportion of missing data. In subsequent research, it would be important to consider the impact of using a mis-specified imputation model. We hypothesize that the effect of the rate of missing data will be ampli - fied when a mis-specified imputation model is used. In other words, MI will perform relatively well when there is little missing data and a mis-specified imputation model is used, whereas it will perform poorly when there is a high rate of missingness and a mis-specified imputa - tion model is used." 95 1067 W4285727872.pdf 13 3 separator 0.9967958 ¶ 1067 1069 W4285727872.pdf 13 4 title 0.9850146 Conclusions 1069 1081 W4285727872.pdf 13 5 separator 0.9944972 ¶ 1081 1083 W4285727872.pdf 13 6 text 0.99900985 "Multiple imputation can be used to estimate the coeffi - cients of a logistic regression model except when the sam - ple is small and the prevalence of missing data is very high." 1083 1266 W4285727872.pdf 13 7 separator 0.9967756 ¶ 1266 1268 W4285727872.pdf 13 8 title 0.9659438 Abbreviations 1268 1282 W4285727872.pdf 13 9 separator 0.98897636 ¶ 1282 1284 W4285727872.pdf 13 10 text 0.77232856 "AMI: Acute myocardial infarction; EFFECT: Enhanced Feedback for Effective Cardiac Treatment; MAR: Missing at random; MCAR : Missing completely at random; MI: Multiple imputation; MICE: Multivariate imputation using chained equations; MSE: Mean squared error; PMM: Predictive mean matching." 1284 1583 W4285727872.pdf 13 11 separator 0.9954932 ¶ 1583 1585 W4285727872.pdf 13 12 title 0.8319867 Acknowledgements 1585 1602 W4285727872.pdf 13 13 separator 0.9785806 ¶ 1602 1604 W4285727872.pdf 13 14 text 0.89109105 Not applicable. 1604 1620 W4285727872.pdf 13 15 separator 0.99583375 ¶ 1620 1622 W4285727872.pdf 13 16 title 0.98231953 Authors’ contributions 1622 1645 W4285727872.pdf 13 17 separator 0.9899293 ¶ 1645 1647 W4285727872.pdf 13 18 text 0.9747134 "PA conceived the study and conducted the simulations. PA wrote the first draft of the manuscript while SvB revised the manuscript for important intellectual content. All authors read and approved the final manuscript." 1647 1871 W4285727872.pdf 13 19 separator 0.99455065 ¶ 1871 1873 W4285727872.pdf 13 20 title 0.8091 Authors’ information 1873 1894 W4285727872.pdf 13 21 separator 0.96681476 ¶ 1894 1896 W4285727872.pdf 13 22 text 0.9123843 Not applicable. 1896 1912 W4285727872.pdf 13 23 separator 0.9953382 ¶ 1912 1914 W4285727872.pdf 13 24 title 0.9854958 Funding 1914 1922 W4285727872.pdf 13 25 separator 0.9919342 ¶ 1922 1924 W4285727872.pdf 13 26 text 0.9979874 "ICES is an independent, non-profit research institute funded by an annual grant from the Ontario Ministry of Health (MOH) and the Ministry of Long- Term Care (MLTC). As a prescribed entity under Ontario’s privacy legislation, ICES is authorized to collect and use health care data for the purposes of health system analysis, evaluation and decision support. Secure access to these data is governed by policies and procedures that are approved by the Information and Privacy Commissioner of Ontario. The opinions, results and conclusions reported in this paper are those of the authors and are independ- ent from the funding sources. No endorsement by ICES or the Ontario MOH or MLTC is intended or should be inferred. The dataset from this study is held securely in coded form at ICES. This research was supported by operating grant from the Canadian Institutes of Health Research (CIHR) (PJT 166161). Dr. Austin is supported in part by a Mid-Career Investigator award from the Heart and Stroke Foundation of Ontario." 1925 2981 W4285727872.pdf 13 27 separator 0.9964337 ¶ 2981 2983 W4285727872.pdf 13 28 title 0.9905854 Availability of data and materials 2983 3018 W4285727872.pdf 13 29 separator 0.9906982 ¶ 3018 3020 W4285727872.pdf 13 30 text 0.9983226 "The dataset from this study is held securely in coded form at ICES. While legal data sharing agreements between ICES and data providers (e.g., healthcare organizations and government) prohibit ICES from making the dataset publicly available, access may be granted to those who meet pre-specified criteria for confidential access, available at www. ices. on. ca/ DAS (email: das@ ices.on.ca)." 3020 3423 W4285727872.pdf 13 31 separator 0.9963119 ¶ 3423 3425 W4285727872.pdf 13 32 title 0.9884801 Declarations 3425 3438 W4285727872.pdf 13 33 separator 0.98699784 ¶ 3438 3440 W4285727872.pdf 13 34 title 0.98382276 Ethics approval and consent to participate 3440 3483 W4285727872.pdf 13 35 separator 0.9779378 ¶ 3483 3485 W4285727872.pdf 13 36 text 0.9985114 "The use of the data in this project is authorized under section 45 of Ontario’s Personal Health Information Protection Act (PHIPA) and does not require review by a Research Ethics Board. Written permission from one of two Institute for Clinical Evaluative Sciences (ICES) Core Scientists is required to use the EFFECT dataset, and a privacy impact assessment for the overall project was submitted to and reviewed by ICES’ Privacy & Legal Office. Project team members are provided varying degrees of encoded data (i.e., direct personal identifiers removed and replaced with a confidential ICES code that enables linkages across datasets) based on the level of access their role permits." 3485 4195 W4285727872.pdf 13 37 separator 0.9960833 ¶ 4195 4197 W4285727872.pdf 13 38 title 0.9210926 Consent for publication 4197 4221 W4285727872.pdf 13 39 separator 0.9468727 ¶ 4221 4223 W4285727872.pdf 13 40 text 0.6927689 Not applicable. 4223 4239 W4285727872.pdf 13 41 separator 0.9947518 ¶ 4239 4241 W4285727872.pdf 13 42 title 0.9751657 Competing interests 4241 4261 W4285727872.pdf 13 43 separator 0.9775124 ¶ 4261 4263 W4285727872.pdf 13 44 text 0.9072955 The authors declare that they have no competing interests. 4263 4322 W4285727872.pdf 13 45 separator 0.99416983 ¶ 4322 4324 W4285727872.pdf 13 46 contact 0.6017383 Author 4324 4331 W4285727872.pdf 13 47 title 0.5155086 details 4331 4339 W4285727872.pdf 13 48 separator 0.9640255 ¶ 4339 4341 W4285727872.pdf 13 49 contact 0.98593444 "1 ICES, G106, 2075 Bayview Avenue, Toronto M4N 3M5, ON, Canada. 2 Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada. 3 Sunnybrook Research Institute, Toronto, ON, Canada. 4 University of Utrecht, Padualaan 14, 3584 CH Utrecht, The Netherlands. 5 Netherlands Organisation for Applied Scientific Research TNO, Leiden, The Netherlands." 4341 4735 W4285727872.pdf 13 50 separator 0.8854294 ¶ 4736 4738 W4285727872.pdf 13 51 paratext 0.98302084 Received: 5 January 2022 Accepted: 30 June 2022 4738 4788 W4285727872.pdf 13 52 separator 0.98991704 ¶ 4788 4790 W4285727872.pdf 13 53 title 0.86686695 References 4790 4801 W4285727872.pdf 13 54 separator 0.9852554 ¶ 4801 4803 W4285727872.pdf 13 55 bibliography 0.997454 "1. Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York: Wiley; 1987." 4804 4891 W4285727872.pdf 13 56 separator 0.86477685 ¶ 4891 4893 W4285727872.pdf 13 57 bibliography 0.9980276 "2. Tu JV, Donovan LR, Lee DS, Wang JT, Austin PC, Alter DA, et al. Effective - ness of public report cards for improving the quality of cardiac care: the EFFECT study: a randomized trial. J Am Med Assoc. 2009;302(21):2330–7." 4894 5124 W4285727872.pdf 13 58 separator 0.9049053 ¶ 5124 5126 W4285727872.pdf 13 59 bibliography 0.9979716 "3. van Buuren S, Groothuis-Oudshoorn K. mice: Multivariate Imputation by Chained Equations in R. J Stat Softw. 2011;45(3)." 5127 5253 W4285727872.pdf 13 60 separator 0.86149836 ¶ 5253 5255 W4285727872.pdf 13 61 bibliography 0.9976994 "4. van Buuren S. Flexible imputation of missing data. 2nd ed. Boca Raton: CRC Press; 2018." 5256 5350 W4285727872.pdf 13 62 separator 0.91342676 ¶ 5350 5352 W4285727872.pdf 13 63 bibliography 0.9979201 "5. van Buuren S. Multiple imputation of multilevel data. In: Hox JJ, Roberts JK, editors. Handbook of Advanced Multilevel Analysis. New York: Rout - ledge; 2011. p. 173–96." 5353 5531 W4285727872.pdf 13 64 separator 0.95752966 ¶ 5531 5533 W4285727872.pdf 13 65 bibliography 0.9979316 "6. White IR, Royston P , Wood AM. Multiple imputation using chained equa- tions: issues and guidance for practice. StatMed. 2011;30(4):377–99." 5534 5679 W4285727872.pdf 13 66 separator 0.9152458 ¶ 5679 5681 W4285727872.pdf 13 67 bibliography 0.99789786 "7. Barnard J, Rubin DB. Small-sample degrees of freedom with multiple imputation. Biometrika. 1999;86(4):948–55." 5682 5798 W4285727872.pdf 13 68 separator 0.9525244 ¶ 5798 5800 W4285727872.pdf 13 69 bibliography 0.9977376 "8. Morris TP , White IR, Royston P . Tuning multiple imputation by predic- tive mean matching and localresidual draws. BMC Med Res Methodol. 2014;14:75." 5801 5959 W4285727872.pdf 13 70 separator 0.952211 ¶ 5959 5961 W4285727872.pdf 13 71 bibliography 0.99787384 "9. Peduzzi P , Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. JClin Epidemiol. 1996;49(12):1373–9." 5962 6156 W4285727872.pdf 13 72 separator 0.93334496 ¶ 6156 6158 W4285727872.pdf 13 73 bibliography 0.99779105 "10. Lee JH. Multiple imputation with large proportions of missing data: how much is too much? 2011. Texas A&M Health Science Center." 6159 6295 W4285727872.pdf 13 74 separator 0.8620632 ¶ 6295 6297 W4285727872.pdf 13 75 bibliography 0.99779063 "11. Madley-Dowd P , Hughes R, Tilling K, Heron J. The proportion of missing data should not be used to guide decisions on multiple imputation. J Clin Epidemiol. 2019;110:63–73." 6298 6481 W4285727872.pdf 13 76 separator 0.9923421 ¶ 6481 6483 W4285727872.pdf 13 77 title 0.98397684 Publisher’s Note 6483 6500 W4285727872.pdf 13 78 separator 0.9906188 ¶ 6500 6502 W4285727872.pdf 13 79 text 0.75108266 "Springer Nature remains neutral with regard to jurisdictional claims in pub - lished maps and institutional affiliations." 6502 6626 W4285727872.pdf 13 0 paratext 0.9877502 Antioxidants 2022 ,11, 1253 6 of 13 0 35 W4283455726.pdf 5 1 separator 0.9950819 ¶ 35 37 W4283455726.pdf 5 2 title 0.8834807 "Table 4. Concentration of AGEs and sRAGE isoforms in not malnourished, at risk of malnutrition and malnourished CKD patients." 37 165 W4283455726.pdf 5 3 separator 0.9693183 ¶ 165 167 W4283455726.pdf 5 4 table 0.99615425 "VariablesNot Malnourished (n= 37)Risk of Malnutrition (n= 51)Malnourished (n= 29)p AGEs (arbitrary unit) 2960 854 3031 779 3079 780 0.79 sRAGE (pg/mL) 2314 1115 2158 1236 2813 1477 0.035 esRAGE (pg/mL) 545 [380–730] 476 [355–680] 648 [408–1049] 0.033 cRAGE (pg/mL) 1704 844 1558 929 1996 1049 0.07 AGEs/sRAGE (arbitrary unit) 1.6 1 1.8 0.9 1.5 0.97 0.17 cRAGE/esRAGE 2.96 0.9 2.8 0.9 2.7 1.1 0.61" 167 597 W4283455726.pdf 5 5 separator 0.95757455 ¶ 597 599 W4283455726.pdf 5 6 text 0.9302378 "Note: AGEs: Advanced Glycation End products; sRAGE: soluble receptor for AGE; esRAGE: endogenous secretory receptor for AGE; cRAGE: cleaved receptor for AGE; CKD: chronic kidney disease. Data are expressed as mean with standard deviation. pvalues less than 0.05 are indicated in bold." 599 888 W4283455726.pdf 5 7 separator 0.9916922 ¶ 888 890 W4283455726.pdf 5 8 paratext 0.98334426 Antioxidants 2022 , 11, x FOR PEER REVIEW 7 of 14 890 940 W4283455726.pdf 5 9 separator 0.94620043 "¶ ¶" 941 951 W4283455726.pdf 5 10 caption 0.9870425 "Figure 1. Box plot representation of AGEs, sRAGE isoforms’ distributions according to different nutritional status, evaluated by MIS. Note:" 951 1094 W4283455726.pdf 5 11 text 0.6155745 "AGEs: Advanced Glycation End products; sRAGE: sol- uble receptor for AGE; esRAGE:" 1095 1179 W4283455726.pdf 5 12 caption 0.4533456 en 1179 1182 W4283455726.pdf 5 13 text 0.47903422 dogenous 1182 1190 W4283455726.pdf 5 14 caption 0.68961304 "secretory receptor for AGE; cRAGE: cleaved receptor for AGE; MIS: mal" 1190 1263 W4283455726.pdf 5 15 text 0.4871899 nutrition 1263 1272 W4283455726.pdf 5 16 caption 0.5841546 -inflammation score 1272 1291 W4283455726.pdf 5 17 text 0.9208293 ". Nutritional status has been grouped according to the severity: 0: non malnourished patients (MIS betw een 0 and 3); 1: patients at risk for malnutrition (MIS between 4 and 7); 2: malnourished pa tients (MIS equal or greater than 8)." 1291 1528 W4283455726.pdf 5 18 separator 0.9971454 ¶ 1529 1531 W4283455726.pdf 5 19 title 0.9946689 3.4. AGEs and RAGEs Isoforms Asso ciation with Inflammatory Markers. 1531 1600 W4283455726.pdf 5 20 separator 0.99530673 ¶ 1601 1603 W4283455726.pdf 5 21 text 0.9994963 "We also performed additional analyses to test for eventual correlation between AGEs, sRAGE, and relative isoforms and pro- inflammatory markers. First of all, AGEs levels were directly and significantly correlated with CRP levels ( p = 0.05), while sRAGE and cRAGE were negatively correlated with it ( p = 0.02 and p = 0.01, respectively). Second- arily, higher values of AGEs /sRAGE ratio significantly corre lated with higher CRP values (p < 0.0001). We performed a series of multivariate linear regression analyses to evaluate whether there was any relationship between AGEs, RAGEs, and their ratio with inflam- matory markers that were mainly associated with malnutrition (i.e., CRP and TNF α)." 1603 2322 W4283455726.pdf 5 22 separator 0.8250407 ¶ 2323 2325 W4283455726.pdf 5 23 text 0.9993536 "Since CRP had a skewed distribution, it was log-transformed for the analysis. Moreover, considering that AGEs, RAGEs, CRP, and TNF α levels are influenced by eGFR, all models were corrected for patients’ eGFR (results of these analyses are reported in Figure S1 and Figure S2 in Supplementary Materials). Al though both sRAGE an d AGEs/sRAGE levels were in general linked to an increase in pro-inflammatory markers, only the association of CRP with sRAGE and AGEs/sRAGE reache d the statistical significance (B = 0.006, p = 0.049 and B = 0.294, p = 0.03 respectively)." 2325 2912 W4283455726.pdf 5 24 separator 0.9970412 ¶ 2913 2915 W4283455726.pdf 5 25 title 0.9946017 3.5. AGEs and RAGEs Isoforms Association with Malnutrition Development 2915 2986 W4283455726.pdf 5 26 separator 0.9959464 ¶ 2987 2989 W4283455726.pdf 5 27 text 0.9994896 "We finally designed two multivariate models to evaluate the eventual association of sRAGE and esRAGE with malnutrition. We built this model after performing interaction analyses, which are shown in Table S2 in Su pplementary Materials. The main factors in- teracting with sRAGE for malnutrition development were Age, CRP and Sex ( p = 0.003; p = 0.03 and p = 0.017, respectively). The same interactions were observed for esRAGE (Age, p = 0.002; CRP, p = 0.02; Sex, p = 0.004). Then, we created two different models, including separately sRAGE or esRAGE (in order to av oid redundancy in the model) with the prin- cipal variables that were associated or sh owed any interaction with overt malnutrition (Table 5)." 2989 3723 W4283455726.pdf 5 28 separator 0.99535704 ¶ 3724 3726 W4283455726.pdf 5 29 caption 0.9786066 "Figure 1. Box plot representation of AGEs, sRAGE isoforms’ distributions according to different nutritional status, evaluated by MIS. Note: " 3726 3869 W4283455726.pdf 5 30 text 0.44371277 AGE 3869 3872 W4283455726.pdf 5 31 caption 0.46367747 s: Advanced Glycation End products 3872 3906 W4283455726.pdf 5 32 text 0.73657256 "; sRAGE: soluble receptor for AGE; esRAGE: endogenous secretory receptor for AGE; cRAGE: cleaved receptor for AGE; MIS: malnutrition-inflammation score. Nutritional status has been grouped according to the severity: 0: non malnourished patients (MIS between 0 and 3); 1: patients at risk for malnutrition (MIS between 4 and 7); 2: malnourished patients (MIS equal or greater than 8)." 3906 4296 W4283455726.pdf 5 33 separator 0.9796648 ¶ 4296 4298 W4283455726.pdf 5 34 text 0.98827183 "We also performed additional analyses to test for eventual correlation between AGEs, sRAGE, and relative isoforms and the main biochemical parameters evaluated in our cohort. " 4298 4476 W4283455726.pdf 5 35 separator 0.5554757 ¶ 4476 4477 W4283455726.pdf 5 36 text 0.9991198 "These results are shown in detail in Table S2 in Supplementary Materials. The main result was the strong negative correlation between all sRAGE isoforms (e.g., sRAGE, esRAGE, and cRAGE) and nPCR ( p< 0.0001, p= 0.003, p= 0.001 respectively). Secondarily, lower AGEs/sRAGE values were significantly correlated with lower albumin and nPCR values (p= 0.005 and p= 0.01 respectively)." 4477 4865 W4283455726.pdf 5 37 separator 0.99695635 ¶ 4865 4867 W4283455726.pdf 5 38 title 0.99463 3.4. AGEs and RAGEs Isoforms Association with Inflammatory Markers 4867 4933 W4283455726.pdf 5 39 separator 0.9957296 ¶ 4933 4935 W4283455726.pdf 5 40 text 0.99953026 "We also performed additional analyses to test for eventual correlation between AGEs, sRAGE, and relative isoforms and pro-inflammatory markers. First of all, AGEs levels were directly and significantly correlated with CRP levels ( p= 0.05), while sRAGE and cRAGE were negatively correlated with it ( p= 0.02 and p= 0.01, respectively). Secondarily, higher" 4935 5295 W4283455726.pdf 5 0 paratext 0.9697107 "8 Eaton G, et al. BMJ Open 2022;12:e067476. doi:10.1136/bmjopen-2022-067476Open access" 0 88 W4312050553.pdf 7 1 separator 0.97731733 ¶ 89 91 W4312050553.pdf 7 2 title 0.9911294 DISCUSSION 91 102 W4312050553.pdf 7 3 separator 0.98913336 ¶ 102 104 W4312050553.pdf 7 4 title 0.81126416 Main findings of 104 121 W4312050553.pdf 7 5 text 0.64448494 this study 121 132 W4312050553.pdf 7 6 separator 0.9478456 ¶ 132 134 W4312050553.pdf 7 7 text 0.99942803 "This research confirms previous publications which noted variance in (A) job title reported by paramedics working in primary care; (B) the clinical work and exam- inations undertaken by paramedics in this setting and (C) entry requirements in terms of clinical experience and education to work in primary care.1 8 This level of variation subsequently leads to confusion around the scope and expectations for the role and contributes to a lack of recognition of paramedics within primary care teams. While attempts have been made through HEE’s Roadmap13 to outline a framework to address this, this is applicable only in England, and such a framework has no influence for paramedics across the devolved nations." 134 880 W4312050553.pdf 7 8 separator 0.98188365 ¶ 881 883 W4312050553.pdf 7 9 text 0.99821156 "The main barriers to engagement with this Roadmap were competing workload pressures affecting the delivery of clinical supervision and uptake of this framework by primary care employers. Such inconsistency contributed to frustration and demotivation among respondents, who were concerned regarding their clinical development in this setting." 883 1243 W4312050553.pdf 7 10 separator 0.9962129 ¶ 1243 1245 W4312050553.pdf 7 11 title 0.9858606 Clinical examinations and procedural skills 1245 1289 W4312050553.pdf 7 12 separator 0.99417174 ¶ 1289 1291 W4312050553.pdf 7 13 text 0.9996983 "Our analysis indicates that length of time in primary care, higher levels of education and status as an independent prescriber all contribute to an increase in the scope of role for paramedics in primary care. Indeed, an inverse association was also observed, where paramedics with lower educational qualifications attended emergency presentations within primary care to a greater extent than those who had undertaken higher education. This outlines that, while the paramedic may transition into primary care due to the virtue of their generalist back- ground, their productivity in primary care may be influ- enced by further education and feedback regarding their clinical experience in this setting. Despite this generalist background, this survey also outlines there are patient groups commonly not seen by paramedics. This could be due to a creep into the paramedic role of nursing policy which emphasise that nurses should refer women who are pregnant to midwifery or physician care if they are not dual registered in this area20; and legacy of instructions for paramedics in ambulance services to convey all chil- dren under the age of 2 to emergency departments, and children under the age of 5 must be seen by a physician if non- conveyed.21" 1291 2605 W4312050553.pdf 7 14 separator 0.93036807 ¶ 2605 2607 W4312050553.pdf 7 15 text 0.99963236 "The survey also highlighted that paramedics working less hours in primary care (such as 1 day a week or 10–20 hours per week) attended emergency presenta- tions in their primary care role to a greater extent when compared with their full- time counterparts. Such hours are common in rotational models, where paramedics, specialist paramedics or advanced paramedics work in a split clinical role between ambulance services and primary care settings in an attempt to increase workforce capacity in primary care and reduce attrition from the ambulance service.22 While the ability for paramedics to attend emergency presentations in primary care may be a benefit for primary care providers, this does little to develop their primary care clinical acumen." 2607 3394 W4312050553.pdf 7 16 separator 0.9971146 ¶ 3394 3396 W4312050553.pdf 7 17 title 0.99123144 Paramedic taxonomy 3396 3415 W4312050553.pdf 7 18 separator 0.9954469 ¶ 3415 3417 W4312050553.pdf 7 19 text 0.99960214 "Some job titles reported by respondents match those endorsed by the College of Paramedics23 (such as ‘Para- medic’, ‘Specialist Paramedic’, ‘Advanced Paramedic’ or ‘Consultant Paramedic’) or those outlined by HEE13 (such as ‘First Contact Practitioner’ and ‘Advanced Prac- titioner’), yet there remains a variety of job titles that do not correlate to these archetypes." 3417 3803 W4312050553.pdf 7 20 separator 0.9539423 ¶ 3803 3805 W4312050553.pdf 7 21 text 0.9995832 "Our analysis indicates that, as paramedics take up more senior roles in primary care (such as ‘advanced paramedic’), their scope of role increases in relation to clinical examinations performed and the clinical presen- tations they attend. Such an increase in scope could be due to their ability to independently prescribe and under - taking postgraduate study. Independent prescribing is typically undertaken by ‘advanced paramedics’ who have completed (or working towards completion of) a master’s degree.24 We noted that these paramedics are more likely to make a diagnosis during the consultation and manage medical and clinical complexity. This is in contrast to ‘paramedics’ or ‘first contact practitioners’, who may have a similar scope of clinical examination, but a reduced scope in relation to managing clinical complexity and making a diagnosis. This supports previous findings where such paramedics are employed in an ‘eye and ears’ approach only.8" 3805 4815 W4312050553.pdf 7 22 separator 0.9696629 ¶ 4815 4817 W4312050553.pdf 7 23 text 0.9995985 "There was a strong correlation with advanced and consultant level roles and undertaking activities related to leadership and management in primary care. This suggests that paramedics may move into leadership roles within primary care that have traditionally been filled by GPs. However, there was no correlation regarding under - taking research activities and job title. This indicates that research activities are less accessible to paramedics in primary care, despite being a pillar of advanced practice, matching previous research findings.25" 4817 5390 W4312050553.pdf 7 24 separator 0.99529725 ¶ 5390 5392 W4312050553.pdf 7 25 title 0.99065864 Strengths and weaknesses of the study 5392 5430 W4312050553.pdf 7 26 separator 0.9908203 ¶ 5430 5432 W4312050553.pdf 7 27 text 0.999407 "This is the first national survey of the paramedic role in primary care within the UK. It has international relevance for primary care workforce transformation in countries where paramedics operate in a similar way to in the UK, such as in Australasia and Canada.26 While the survey was distributed across each UK nation, this was either through the College of Paramedics or on social media— and thus paramedics not registered with the professional body, or not on social media, may not have had access." 5432 5959 W4312050553.pdf 7 28 separator 0.74658614 ¶ 5960 5962 W4312050553.pdf 7 29 text 0.99929947 "At best, the surveyed respondents constitute one- third of the paramedic workforce in primary are, and therefore, results should not be generalised to the entire population of paramedics working in the primary care." 5962 6187 W4312050553.pdf 7 30 separator 0.87344986 ¶ 6187 6189 W4312050553.pdf 7 31 text 0.9992295 "It is noted that the uptake of the survey in Northern Ireland and Scotland was low. The number of paramedics working in primary care roles is likely to be fewer than" 6189 6361 W4312050553.pdf 7 0 paratext 0.9851339 Page 13/21 0 10 W4385877790.pdf 12 1 bibliography 0.9780415 Jiahong Lu: Conceptualization, Software, Writing-review. Kaiwen Hao: Writing-original draft, Editing. 10 111 W4385877790.pdf 12 2 separator 0.99298453 ¶ 111 113 W4385877790.pdf 12 3 contact 0.44385564 Yum 113 117 W4385877790.pdf 12 4 bibliography 0.4904108 ing Wang 117 125 W4385877790.pdf 12 0 title 0.8502016 53Methodology 0 13 W4379377914.pdf 4 1 separator 0.99623215 ¶ 13 15 W4379377914.pdf 4 2 text 0.9960099 "TheAERIoealgorithm,basedontheoptimalestimationmethod,comprehensivelyconsiderstheobservationinformationand atmosphericpriorinformation,iterativelysearchingfortheatmosphericstatethatmostconformstotheobservationandprior constraints." 15 249 W4379377914.pdf 4 3 separator 0.9915528 ¶ 249 251 W4379377914.pdf 4 4 math 0.72203803 "    11 1 1 1 0 0T T m n nen a ne n n n F       XXKSKSKSY XKXX, (1)115" 251 348 W4379377914.pdf 4 5 separator 0.9859897 ¶ 348 350 W4379377914.pdf 4 6 text 0.997454 "Here,Xistheprofileoftheatmosphericstatetoberetrieved,X0isthefirst-guessprofileoftheatmosphere,Ymisthe observedradiancevector,F(X)istheAERIobservedspectrum,Seistheobservationerrorcovariancematrix,Saisthe backgroundcovariancematrix,andnrepresentsthenumberofiterations.ThesuperscriptsTand-1implythematrix transposeandinverse,respectively." 350 692 W4379377914.pdf 4 7 separator 0.9602792 ¶ 692 694 W4379377914.pdf 4 8 text 0.9965741 "Toimprovethestabilityoftheretrievalalgorithm,theregularizationparameterwasintroducedinFormula(1), 120 whichissetas10fixedvaluesfromlargetosmall([1000,300,100,30,10,3,10,1]).Asdecreaseswithiterations progress,moreobservationinformationisintroducedtoimprovetheretrievalaccuracy.Theretrievalisnotallowedto convergeuntildecreasesto1andthefollowingconvergencecriterionissatisfied." 694 1079 W4379377914.pdf 4 9 separator 0.9880632 ¶ 1079 1081 W4379377914.pdf 4 10 paratext 0.97026706 11 11 1081 1087 W4379377914.pdf 4 11 separator 0.9879458 ¶ 1087 1089 W4379377914.pdf 4 12 title 0.4524881   1089 1096 W4379377914.pdf 4 13 math 0.4174405  1096 1099 W4379377914.pdf 4 14 separator 0.6804677 ¶ 1099 1101 W4379377914.pdf 4 15 math 0.86178476 N) () (index_e convergencn n n nXXSXX, (2) ¶ 1101 1146 W4379377914.pdf 4 16 text 0.5155051 Nrepresentsthedimensionoftheretrievedatmosphericstatevector. 1146 1207 W4379377914.pdf 4 17 math 0.36412495 125 1207 1211 W4379377914.pdf 4 18 separator 0.99413514 ¶ 1211 1213 W4379377914.pdf 4 19 caption 0.994471 Figure1.FlowchartoftheFastAERIoeretrievalprocess.NotethattheredlineindicatestheJacobianupdatingprocess. 1213 1317 W4379377914.pdf 4 20 separator 0.9823035 ¶ 1317 1319 W4379377914.pdf 4 21 text 0.97366494 "TheupdatingoftheJacobiansintheaboveretrievalprocessrequiresthecalculationoftheopticalthicknessorradiation intensityofdifferentatmosphericconstituentsateachheight.OntheconditionthattheJacobianiscalculatedforeachhttps://doi.org/10.5194/egusphere-2023-637" 1319 1574 W4379377914.pdf 4 22 separator 0.9787496 ¶ 1574 1576 W4379377914.pdf 4 23 paratext 0.9557757 "Preprint. Discussion started: 12 May 2023 c Author(s) 2023. CC BY 4.0 License." 1576 1657 W4379377914.pdf 4 24 separator 0.9961457 ¶ 1657 1659 W4379377914.pdf 4 0 paratext 0.98659056 BioMedResearchInternational 7 0 29 W2292183681.pdf 6 1 separator 0.98989975 ¶ 29 31 W2292183681.pdf 6 2 table 0.9401821 "ND4 HR0153045607590105120∗ Control WSAsA (μmol g−1DW) (a)ND4 HR0.00.20.40.60.81.0GSH (μmol g−1DW) Control WS (b)" 31 156 W2292183681.pdf 6 3 separator 0.9920192 ¶ 156 158 W2292183681.pdf 6 4 caption 0.99205095 Figure5:Effectofwaterstress(WS)onascorbate(AsA)(a)andglutathione(GSH)(b)contentsin Cerasushumilis leavesofHuai’rou(HR) 158 277 W2292183681.pdf 6 5 separator 0.95904404 ¶ 277 279 W2292183681.pdf 6 6 caption 0.61924887 and No 279 286 W2292183681.pdf 6 7 text 0.7394892 ngda4 (ND4). Samples were collected 286 321 W2292183681.pdf 6 8 caption 0.64053714 after 321 327 W2292183681.pdf 6 9 text 0.8983111 21d of treatment. The data are the mean of at least three replicates with standard errors 327 417 W2292183681.pdf 6 10 separator 0.7356522 ¶ 417 419 W2292183681.pdf 6 11 text 0.9672866 "s h o w nb yv e r t i c a lb a r s .A s t e r i s k( ∗) indicates significant difference with control groups (well-watered) at the 0.05 level of probability by Duncan’sMultiple-RangeTest." 419 609 W2292183681.pdf 6 12 separator 0.99139065 ¶ 609 611 W2292183681.pdf 6 13 table 0.8832497 "ND4 HR0123456cAPX (relative quantitative)∗ Control WS (a)ND4 HR048121620DHAR (relative quantitative)∗ Control WS (b)" 611 740 W2292183681.pdf 6 14 separator 0.9896009 ¶ 740 742 W2292183681.pdf 6 15 caption 0.99566954 "Figure 6: Effects of water stress (WS) on expression pattern of cytosol APX (cAPX) (a) and dehydroascorbate reductase (DHAR) (b) in Cerasushumilis leavesofHuai’rou(HR)andNongda4(ND4)byqRT-PCR.Dataarethemeansofatleastfivereplicateswithstandarderrors" 742 993 W2292183681.pdf 6 16 separator 0.8729552 ¶ 993 995 W2292183681.pdf 6 17 caption 0.95985943 "s h o w nb yv e r t i c a lb a r s .A s t e r i s k( ∗) indicates significant difference with control groups (well-watered) at the 0.05 level of probability by Duncan’sMultiple-RangeTest." 995 1185 W2292183681.pdf 6 18 separator 0.9941379 ¶ 1185 1187 W2292183681.pdf 6 19 text 0.99817353 "resultsonSODisoenzymeactivities(Figure3)suggestedthat Fe-SODandMn-SODcouldplaythemainroleindetoxifica-tionofsuperoxideradicalsinchloroplastsandmitochondria.Similar report has been shown in wheat varieties subjectedto continuous soil drought [34]. Indirect evidence has beenreported by Zhang et al. who found that overexpression ofTamarix albiflonum TaMnSOD increasesdroughttolerancein transgenic cotton [35]. The decrease of Cu/Zn-SOD activityfor ND4 plants exposed to WS (Figure3(b)) was likelyattributedtotheinfluenceofH 2O2.Similarresultshavebeen reportedbySmirnoff[36]." 1187 1769 W2292183681.pdf 6 20 separator 0.98898387 ¶ 1769 1771 W2292183681.pdf 6 21 text 0.9947782 "CATandAPXintheAsA-GSHcycleenzymesarerespon- sible for the decomposition of H2O2generated by SOD in differentcellularorganelles.WefoundthattheactivityofCATandAPXshowedsimilarpatternsofchangetothatobservedfor SOD activity in HR plants (Figures 4(a) and 4(b)),suggestingthatCATandAPXworkinacoordinatedmannertoscavengeH 2O2.ThemaintenanceofCATactivityinleaves" 1771 2133 W2292183681.pdf 6 0 paratext 0.98745155 1ISSN 0100-2945 DOI: http://dx.doi.org /10.1590/0100-29452018108erratum 0 78 W4248415337.pdf 0 1 separator 0.98893523 ¶ 78 80 W4248415337.pdf 0 2 title 0.9745001 ERRATUM 80 88 W4248415337.pdf 0 3 separator 0.98740554 ¶ 88 90 W4248415337.pdf 0 4 bibliography 0.9618062 "Erratum of article: Machado, B. D., Magro, M., Souza, D. S. de, Rufato, L., & Kretzschmar, A. A. Study on the growth and spatial distribution of the root system of different european pear cultivars on quince rootstock combinations." 90 325 W4248415337.pdf 0 5 separator 0.89911425 ¶ 325 327 W4248415337.pdf 0 6 bibliography 0.6232862 Rev. Bras. Frutic ., 327 348 W4248415337.pdf 0 7 paratext 0.5871299 40(2), 348 355 W4248415337.pdf 0 8 bibliography 0.46710876 355 356 W4248415337.pdf 0 9 paratext 0.67485744 e-108. https://dx.doi.org/ 10.1590/0100-29452018108 356 407 W4248415337.pdf 0 10 separator 0.9955815 ¶ 407 409 W4248415337.pdf 0 11 text 0.729919 In the page 1: 409 424 W4248415337.pdf 0 12 title 0.50746787 Authors’ affiliations 424 446 W4248415337.pdf 0 13 text 0.71468675 - footnote 446 457 W4248415337.pdf 0 14 separator 0.8993695 ¶ 457 459 W4248415337.pdf 0 15 text 0.7698361 where it reads: 459 475 W4248415337.pdf 0 16 separator 0.89274734 ¶ 475 477 W4248415337.pdf 0 17 contact 0.96303785 1Agronomist, Dr. in Plant Production, Institul Federal de Urupema, Urupéma-SC. Email: bruno. dalazem@ifsc.edu.br 477 590 W4248415337.pdf 0 18 separator 0.9283354 ¶ 590 592 W4248415337.pdf 0 19 text 0.4328676 should read 592 604 W4248415337.pdf 0 20 contact 0.596183 : 604 605 W4248415337.pdf 0 21 separator 0.59100336 ¶ 605 607 W4248415337.pdf 0 22 contact 0.977869 1Agronomist, Dr. in Plant Production, Instituto Federal de Urupema, Urupéma-SC. Email: bruno.dalazem@ifsc.edu.br 607 720 W4248415337.pdf 0 23 separator 0.9926363 ¶ 720 722 W4248415337.pdf 0 24 paratext 0.55625045 Rev 722 726 W4248415337.pdf 0 25 bibliography 0.57100034 . Bras. Frutic., Jab 726 746 W4248415337.pdf 0 26 paratext 0.52154905 o 746 747 W4248415337.pdf 0 27 bibliography 0.6757 ticabal, 2018, v. 40, n. 3: (e-108erratum ) 747 791 W4248415337.pdf 0 0 paratext 0.96547806 "ЕКОНОМІКА ТА УПРАВЛІННЯ Економічний вісник університету | Випуск No 3 7/1 121" 0 81 W4285039838.pdf 4 1 separator 0.9885813 ¶ 82 84 W4285039838.pdf 4 2 text 0.9979743 "regarding the further employment of a postgraduate / doctoral student with successful protection and obtaining the appropriate degree. As a result, the la rgest proportion of those who defended the dissertation work in the relevant higher education institutions. Also, the largest proportion among doctors of philosophy (candidates of science) is occupied by researchers, whose average age is 30- 39 years (29.3% of the total). The proportion of researchers over the age of 60 years is 22.8%. Among doctors of sciences, these indicators are 4.2% and 56.7% respectively." 85 668 W4285039838.pdf 4 3 separator 0.987715 ¶ ¶ 670 676 W4285039838.pdf 4 4 title 0.94615495 Table 1 . Dynamics of Changes in Key Performance Indicators of Ukrainian Higher Educational Instit utions* 676 783 W4285039838.pdf 4 5 separator 0.9486625 ¶ 785 787 W4285039838.pdf 4 6 table 0.98915184 "Indicator Educational years Rate of growth (decrease),% 2010/ 11 2011/ 12 2012/ 13 2013/ 14 2014/ 15 2015/ 16 11/ 201016/ 2015 15/ 201416/ 2015" 787 967 W4285039838.pdf 4 7 separator 0.8441616 ¶ ¶ 967 973 W4285039838.pdf 4 8 table 0.9954601 "І - ІІ levels of accreditation Number of institutions, units 483 479 469 458 387 371 76,8 95,9 Number of students, thousand persons 351,4 347,2 335,9 319,6 251,3 230,1 65,5 91,6 Accepted, thousands of people 125,1 102,2 96,7 90,9 69,5 63,2 50,5 90,9 Thousands of people were released 107,4 94,0 89,8 88,7 79,1 73,4 68,3 92,8 The number of students per 10 thousand population 81 80 78 74 59 54 66,7 91,5 Teaching staff, persons: 1. Teachers: - Candidates of Sciences 937 964 951 986 949 1016 108,4 107,1 - Doctor of Sciences 58 56 55 43 49 60 103,4 122,4 - Associate Professors 341 328 325 288 271 245 71,8 90,4 - Professors 56 57 53 44 42 54 96,4 128,6 2. Scientific and pedagogical workers: - Candidates of Sciences 114 121 83 89 126 170 149,1 134,9 - Doctor of Sciences 23 23 18 14 17 34 147,8 200,0 - Associate Professors 52 58 25 37 51 62 119,2 121,6 - Professors 22 20 19 17 19 33 150,0 173,7 ІІІ - ІV levels of accreditation Number of institutions, units 330 326 316 309 277 288 87,3 104,0 Amount of students, millions of people 2,07 1,9 1,77 1,67 1,44 1,38 66,5 95,6 Accepted, thousands of people 381,4 307,3 331,2 337,4 291,6 259,9 68,2 89,1 Thousands of people were released 528,9 515,0 505,4 471,7 405,4 374,0 70,7 92,3 The number of students per 10 thousand population 476 439 410 389 335 322 67,6 96,1 Teaching staff, persons: 1. Teachers: - Candidates of Sciences 529 604 658 772 796 1151 217,6 144,6 - Doctor of Sciences 22 28 18 29 33 67 304,5 203,0 - Associate Professors 205 229 226 264 256 364 177,6 142,2 - Professors 15 26 16 24 22 45 300,0 204,5 2. Scientific and pedagogical workers: - Candidates of Sciences 66689 67057 67675 69582 62158 61266 91,9 98,6 - Doctor of Sciences 13367 13436 13826 14269 12682 13072 97,8 103,1 - Associate Professors 44608 45060 46127 47416 42600 42414 95,1 99,6 - Professors 12158 12211 12484 12609 11249 11476 94,4 102,0" 973 3066 W4285039838.pdf 4 9 separator 0.73507375 ¶ 3068 3070 W4285039838.pdf 4 10 table 0.7921823 * Compiled and calculated on the basis of [6] 3070 3116 W4285039838.pdf 4 11 separator 0.9773991 ¶ ¶ 3118 3124 W4285039838.pdf 4 12 text 0.99944896 "The above analysis shows that the greatest proportion among scientific researchers and scientific and pedagogical workers is occupied by persons whose age is not more than 40 years, which indicates a relatively small or even missing experience of practical work in the field of research conducted, or exceeds 60 years , that in the conditions of rapid pace of change of scientific and technological progress, testifies to « moral obsolete» practical training of the given staff, obtained during the Soviet Union." 3124 3651 W4285039838.pdf 4 13 separator 0.93689585 ¶ 3653 3655 W4285039838.pdf 4 14 text 0.99947166 "In today's business environment, public authorities and local self -government bodies, together with representatives of business entities of all forms of ownership, are interested in developing a coherent mechanism for training specialists for current curri cula, which will not only reduce the unemployment rate among economically active population, but also create effective development model and improve the overall quality of life. It is necessary to determine the correlation of the indicators of the general need of the national economy in the specialists with the" 3655 4238 W4285039838.pdf 4 0 text 0.9764887 "бюджет ів, п ідвищення р івня менеджменту, посилення конкуренц ії в національн ій економ іці, розвитку соц іальної сфери." 0 124 W2781041999.pdf 3 1 separator 0.99511135 ¶ 126 128 W2781041999.pdf 3 2 title 0.67838126 Розглянемо прям і іноземн і інвестування за пер іод з 2011 по 2015 роки 128 202 W2781041999.pdf 3 3 text 0.68412465 ", за даними Державної Служби Статистики України. На рис.1 представимо динам іку інвестиц ій в економ іку України за досл іджуваний пер іод" 202 347 W2781041999.pdf 3 4 caption 0.6486674 : 347 348 W2781041999.pdf 3 5 separator 0.9314098 "¶ ¶ ¶" 349 364 W2781041999.pdf 3 6 caption 0.99468637 Рис.1. Прям і іноземн і інвестиц ії у Україну за 2011 -2015 роки [2] 364 434 W2781041999.pdf 3 7 separator 0.9336311 "¶ ¶" 435 445 W2781041999.pdf 3 8 text 0.99925953 "Отже, як бачимо з рис. 1 , загальний обсяг іноземних інвестиц ій у 2011 році становив 49362,3 млн. дол., у 2012 роц і відпов ідно – 54462,4 млн. дол., у 2013 роц і 58156,9 млн. дол., тобто сл ід відмітити, що протягом трьох рок ів, до 2014 р., надходження П ІІ було регулярними та стаб ільними. Темпи росту іноземних вкладень у 2012 та 2013 роках в ідпов ідно до 2011 року становили 110,3% та 117,8%." 445 866 W2781041999.pdf 3 9 separator 0.95473397 ¶ 868 870 W2781041999.pdf 3 10 text 0.9985689 "Починаючи з 2014 року загальний обсяг іноземних інвестиц ій скоротився проти 2011 року на 3446,3 млн. дол. і становив 45916 млн. дол., у 2015 роц і скорочення проти 2011 року становить 5990,9 млн. дол., і становить – 43371,4 млн. дол. В ідпов ідно темпи росту у 2014 та 2015 роках становили 93,0% та 87,9%" 870 1190 W2781041999.pdf 3 11 separator 0.97939634 ¶ 1192 1194 W2781041999.pdf 3 12 text 0.99890846 "Причин тако го спов ільнення багато: стан в ійни у якому перебуває Україна, макроеконом ічне гальмування, зупинення низки промислових підприємств, стр імка девальвац ія та інфляц ія, зниження р івня споживання." 1194 1421 W2781041999.pdf 3 13 separator 0.979201 ¶ 1423 1425 W2781041999.pdf 3 14 text 0.9989054 "Важливою складовою анал ізу інвестиц ійних процес ів є досл ідження географ ічної структури залучених інвестиц ій. Відмітимо, що остання формується п ід впливом багатьох чинник ів, серед головних – розвиток зовн ішньоеконом ічних зв’язк ів зі стратег ічними партнерами (до 2002 р. цим партнером були США та Рос ія, сьо годн і головним стратег ічним економ ічним партнером країни є ЄС) та потреба у диверсиф ікації м іжнародної інвестиц ійної д іяльност і." 1425 1905 W2781041999.pdf 3 15 separator 0.9954042 ¶ 1907 1909 W2781041999.pdf 3 0 paratext 0.98292387 Зборник радова Правног факултета у Новом Саду , 3/2013 0 59 W2027462320.pdf 10 1 separator 0.92368263 ¶ ¶ 60 66 W2027462320.pdf 10 2 contact 0.9399833 "341 Dragana Ćorić, Ph.D., Assistant Professor University of Novi Sad Faculty of Law Novi Sad" 67 167 W2027462320.pdf 10 3 separator 0.4716451 168 169 W2027462320.pdf 10 4 contact 0.52328223 ¶ 169 170 W2027462320.pdf 10 5 separator 0.86552614 "¶ ¶" 172 183 W2027462320.pdf 10 6 title 0.9937014 Glosa about Political Ethics 183 212 W2027462320.pdf 10 7 separator 0.9957677 ¶ 214 216 W2027462320.pdf 10 8 text 0.99944216 "Abstract: Debates about political ethics aren 't new. They have been pre- sent since ancient Greek philosophers. Machiavelli set some new principles, re- garding amoral behavior of the prince, which could be quite legitimate and le-gal. He didn't invented anything new, he just admitted that, that was the reality." 218 538 W2027462320.pdf 10 9 separator 0.5429647 539 540 W2027462320.pdf 10 10 text 0.9935336 "¶ Some modern authors think that ethics and politics should be departed always, some other think that they should cooperate. In the end of the day, the voters are those who must face with amoral behavior of politicians, because it seems that politicians don't recognize ethics at all? Or is it just look like? In this pa-per, we will try in short to tell someth ing about origins of political ethics, its burning issues, and about possible ways of implementation of political ethics and its development." 540 1053 W2027462320.pdf 10 11 separator 0.9848213 ¶ 1054 1056 W2027462320.pdf 10 12 text 0.90072906 Key words: ethics, politics 1056 1084 W2027462320.pdf 10 0 text 0.9678343 "tumour prior to local therapy or as adjuvant treatment after surgical resection [5,12]." 0 89 W2099529965.pdf 6 1 title 0.9769813 Neoadjuvant chemotherapy 89 113 W2099529965.pdf 6 2 text 0.9992476 "Neoadjuvant CT before surgery in surgically resectable SCCB has been investi-gated in several retrospective studies and in one phase II prospective study [12,33]. In addition primary CT was used in sequence with radiation to increase the efficacyof RT [4,10,15,32]." 113 385 W2099529965.pdf 6 3 separator 0.9592343 ¶ 385 387 W2099529965.pdf 6 4 text 0.999555 "Neoadjuvant CT in bladder SCC cancer has fourtheoretical advantages [36,37]:*the early treatment of micrometastatic disease,*the systemic treatment is better tolerated by allow- ing the preoperative administration of CT drugs in optimal doses with less toxicity,*SCCB is highly chemosensitive disease; the vastmajority of patients have great responses,*downstaging, which facilitates the surgicaltechniques.One retrospective cohort study and one phase IIclinical trial demonstrated the advantage of CT in neoadjuvant setting." 387 919 W2099529965.pdf 6 5 separator 0.97744477 ¶ 919 921 W2099529965.pdf 6 6 text 0.9996314 "In the MD Anderson retrosp ective study, 46 operable patients were included; the first group of patient (n = 21) was treated with 4 cycles of neoadjuvant sequentialCT regimen based on ifosfamide plus doxorubicin atday 1 repeated every 42 days and etoposide pluscisplatin at day 21 repeated every 42 days; the secondgroup was treated with surgery alone (n = 25). At lastfollow-up, 5-year survival was significantly higher in CTgroup: 78% versus 36% in surgery alone group (p = 0.026) [12]. In addition, the results of the MD Anderson phase II clinical trial recently published, confirmed the- ses results. In this prospective study, 30 eligible patientswere included, eighteen of them were surgically resect-able and 12 were surgically unresectable. Operablepatients have been treated with neoadjuvant CT fol-lowed by surgery. At last follow-up, OS and 5 years sur-vival in resectable group was equal to 58 months and80%, respectively [33]." 921 1871 W2099529965.pdf 6 7 separator 0.9627532 ¶ 1871 1873 W2099529965.pdf 6 8 text 0.9974111 "Based on these data, neoadjuvant CT should be con- sidered as the treatment of choice of surgically resect-able SCCB." 1873 1993 W2099529965.pdf 6 9 title 0.975993 Adjuvant chemotherapy 1993 2014 W2099529965.pdf 6 10 text 0.99733156 "No clear data defines the role of adjuvant CT after primary surgery of invasive bladderSCC. Only one retrospective study conducted by theUniversity of Southern California has addressed thisquestion. In the published article, the authors concluded that adjuvant CT may provide improved survival com- pared with cystectomy alone [6]. In addition, the MayoClinic recommendations propose cystectomy alone forpatients with stage II disease, and adjuvant chemother-apy for patients with stage III and VI (M0) disease [5].However, it is important to note that many institutionswho followed the Mayo recommendations of initialTable" 2014 2644 W2099529965.pdf 6 11 title 0.5969999 3 Treatment 2644 2656 W2099529965.pdf 6 12 text 0.61793905 2656 2657 W2099529965.pdf 6 13 title 0.808512 strategies and outcome of bladder small cell carcinoma 2657 2711 W2099529965.pdf 6 14 text 0.668643 2711 2712 W2099529965.pdf 6 15 title 0.62807155 according 2712 2721 W2099529965.pdf 6 16 text 0.93037534 "to the most important studies published in the English literature. (Continued)" 2721 2802 W2099529965.pdf 6 17 separator 0.99600995 ¶ 2802 2804 W2099529965.pdf 6 18 table 0.96563905 "Ismaili 2008 [7] 14 Retrospective II(4) III(5) IVM0(5)RC®CT(4) RC(5) CT®RC(2) CT(1) RCT(1) None(1)-Survival in mixed SCCB > survival in pure SCCB, p= 0.01, -CT + Surgery > Surgery" 2804 3000 W2099529965.pdf 6 19 separator 0.51453495 ¶ 3000 3002 W2099529965.pdf 6 20 table 0.9478667 "Bex 2009 [15] 17 Retrospective LD(17): -T2(14) -T3(2)-T4a(1)CT®RT (60: 56-70Gy) (17) Salvage RC (3)-All patients have been treated with sequential chemoradiotherapy -OS = 32.5 months -2, 3, and 5 years survival = 56%, 47%, and 36% respectively" 3002 3260 W2099529965.pdf 6 21 separator 0.97878945 ¶ 3260 3262 W2099529965.pdf 6 22 table 0.5750934 Sie 3262 3266 W2099529965.pdf 6 23 bibliography 0.531208 fker-Radtke 3266 3277 W2099529965.pdf 6 24 table 0.96587616 "2009 (MD Anderson) [33]30 Phase II Resecable patients (18): T2N0M0CT®RC -5 years survival in operable group = 80% -OS = 58 months vs 13.3 months, in operable vs non operable patients, respectively -Incidence of brain metastasis in stage III/IV = 50% Unresecable patients(12): T3b-4aN0M0CT alone Bex 2010 [40] 51 Retrospective LD(39) CT ®RT -Survival of patients with LD = 35 months vs 6 months in patients with ED. -Incidence of brain metastasis = 10.5% ED(12) CT" 3277 3763 W2099529965.pdf 6 25 separator 0.8774576 ¶ 3763 3765 W2099529965.pdf 6 26 table 0.6964242 "Abbreviations. OS = overall survival; NS = no significant; RC = radical cystectomy; TURBT = transurethral resection of the bladder tumour; ACT = adjuv ant chemotherapy; NCT = neoadjuvant chemotherapy; PC = partial cystectomy; CT = chemotherapy; RCT = concurrent chemoradiotherapy; PRT = palliative radiotherapy; NR = no reached; LD = limited disease; ED = extensive disease" 3765 4143 W2099529965.pdf 6 27 text 0.38111004 ; 4143 4144 W2099529965.pdf 6 28 table 0.48469567 SCCB 4144 4150 W2099529965.pdf 6 29 math 0.33287394 = 4150 4151 W2099529965.pdf 6 30 table 0.47075528 small cell carcinoma of the bladder 4151 4187 W2099529965.pdf 6 31 text 0.47303945 "; Definition for LD (limited disease): in analogy to SCLC, patient with any local stage, no distant metastases and involvement of maximally one loco regional lymph node less than 2 cm in imaging (cTx ¶" 4187 4390 W2099529965.pdf 6 32 math 0.40544364 cN0-1 4390 4396 W2099529965.pdf 6 33 text 0.37417877 M 4396 4398 W2099529965.pdf 6 34 math 0.40969273 0) [15]; 4398 4406 W2099529965.pdf 6 35 text 0.40934706 Definition for ED (extensive disease 4406 4443 W2099529965.pdf 6 36 math 0.3719327 ): 4443 4445 W2099529965.pdf 6 37 text 0.37385526 unresectable and metastatic disease 4445 4481 W2099529965.pdf 6 38 math 0.31577426 [15] 4481 4486 W2099529965.pdf 6 39 text 0.32540423 . 4486 4487 W2099529965.pdf 6 40 paratext 0.9622904 "Ismaili Orphanet Journal of Rare Diseases 2011, 6:75 http://www.ojrd.com/content/6/1/75Page 7 of 11" 4487 4588 W2099529965.pdf 6 0 bibliography 0.8596709 reported strains of L.plantarum , 0 33 W2999253318.pdf 8 1 text 0.8433708 "with the exception of the strain TMW 1.1478 (" 33 81 W2999253318.pdf 8 2 bibliography 0.5592625 P 81 83 W2999253318.pdf 8 3 text 0.950377 "rechtl, Wefers, Jacob, & Vogel 2018), which also has glucose and galactose in the repeat but not glucosamine or phosphate, con- nected via a di fferent sequence from that of our strain. Other studies have focused on the genetic composition and the immunologicalproperties while the structural details have been ignored ( Lee et al., 2016 ;Remus et al., 2012 )." 83 450 W2999253318.pdf 8 4 separator 0.99456227 ¶ 450 452 W2999253318.pdf 8 5 text 0.99877286 "Secondly, we investigated the biological e ffects of the pure capsular polysaccharide (CPS-100) and of the teichoic acids (CPS-400) in rela-tion to the e ffects triggered from total CPS fraction. On primary ob- servation, it appeared that CPS induces signi ficant IFN γand IL-10 re- sponses ( Fig. 8b). Accordingly, we investigated the cytokine pro files induced from the two most representative fractions of the surfacepolysaccharides, CPS-100 and CPS-400, and we found that CPS-100 (Fig. 8) was the immunostimulatory component of CPS because of the remarkable e ffect in IFN γproduction (EC 503.157 μM), including other cytokines, except IL-10. In contrast, CPS-400 had no activity in any of the assays ( Fig. 8) so the nature of the IL-10 stimulation by un- fractionated CPS is still elusive. Though indicative, these findings warrant an in-depth proof-of-concept immunological investigation of these molecules in health and disease." 452 1407 W2999253318.pdf 8 6 separator 0.9947078 ¶ 1407 1409 W2999253318.pdf 8 7 text 0.9973291 "In conclusion, our study demonstrates that the surface poly- saccharides from a commensal microbiota related bacterium, L. plan- tarum IMB19 is a complex mixture made of teichoic acids and of a capsular polysaccharide. Such complexity is in line with the findings of other authors ( Remus et al., 2012 ) including ourselves ( Speciale et al., 2019 ), which report that the bacterial surface is covered by a complex blend of di fferent carbohydrate polymers each with a di fferent activity profile." 1409 1917 W2999253318.pdf 8 8 separator 0.9921369 ¶ 1917 1919 W2999253318.pdf 8 9 text 0.9986333 "Our opinion is that the ability of bacteria to modulate the expression (and the amount) of each polymer, teichoic acid included ( Brown et al., 2013 ;Remus et al., 2012), is the key for their adaptation to the host environment, and further studies are necessary to unravel this issue." 1919 2210 W2999253318.pdf 8 10 separator 0.9940938 ¶ 2210 2212 W2999253318.pdf 8 11 title 0.9336691 CRediT authorship contribution statement 2212 2253 W2999253318.pdf 8 12 separator 0.9539493 ¶ 2253 2255 W2999253318.pdf 8 13 bibliography 0.9959249 "Pilar Garcia-Vello: Formal analysis, Investigation, Writing - ori- ginal draft. Garima Sharma: Formal analysis, Investigation, Writing - original draft. Immacolata Speciale: Formal analysis, Investigation." 2255 2465 W2999253318.pdf 8 14 separator 0.8324157 ¶ 2465 2467 W2999253318.pdf 8 15 bibliography 0.99604034 "Antonio Molinaro: Formal analysis, Investigation, Writing - review & editing. Sin-Hyeog Im: Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing - review & editing. Cristina De Castro: Conceptualization, Formal analysis, Funding acquisition, Methodology,Project administration, Resources, Supervision, Writing - review & editing." 2467 2880 W2999253318.pdf 8 16 separator 0.9900974 ¶ 2880 2882 W2999253318.pdf 8 17 title 0.79811805 Acknowledgements 2882 2899 W2999253318.pdf 8 18 separator 0.9827918 ¶ 2899 2901 W2999253318.pdf 8 19 paratext 0.5883247 "P. G-V. fellowship is supported by the Train2Target project granted from the European Union ’s Horizon 2020 framework program for re-" 2901 3037 W2999253318.pdf 8 20 text 0.45571825 3037 3038 W2999253318.pdf 8 21 paratext 0.669865 ¶ search and innovation (Project #721484)Appendix A. Supplementary data 3038 3109 W2999253318.pdf 8 22 separator 0.65825725 ¶ 3109 3111 W2999253318.pdf 8 23 paratext 0.5768723 Supplementary material related to this article can be found, in 3111 3175 W2999253318.pdf 8 24 text 0.46568772 the 3175 3179 W2999253318.pdf 8 25 paratext 0.55699956 ¶ online version, at doi: https://doi.org/10.1016/j.carbpol.2020.115857 . 3179 3253 W2999253318.pdf 8 26 separator 0.988018 ¶ 3253 3255 W2999253318.pdf 8 27 paratext 0.4548394 Reference 3255 3265 W2999253318.pdf 8 28 title 0.58893436 s 3265 3266 W2999253318.pdf 8 29 separator 0.97370136 ¶ 3266 3268 W2999253318.pdf 8 30 bibliography 0.99820286 "Baarlen, P., Wells, J. M., & Kleerebezem, M. (2013). Regulation of intestinal homeostasis and immunity with probiotic lactobacilli. Trends in Immunology, 34 , 208 –215." 3268 3439 W2999253318.pdf 8 31 separator 0.9045629 ¶ 3439 3441 W2999253318.pdf 8 32 bibliography 0.99822325 "Bock, K., & Pedersen, C. (1983). Carbon-13 nuclear magnetic resonance spectroscopy of monosaccharides. Advances in Carbohydrate Chemistry and Biochemistry, 41 ,2 7 –65." 3441 3612 W2999253318.pdf 8 33 separator 0.9556153 ¶ 3612 3614 W2999253318.pdf 8 34 bibliography 0.99809223 "Bron, P. A., Tomita, S., van Swarm, I. I., Remus, D. M., Meijerink, M., Wels, M., et al. (2012). Lactobacillus plantarum possesses the capability for wall teichoic acidbackbone alditol switching. Microbial Cell Factories, 11 , 123 –137." 3614 3853 W2999253318.pdf 8 35 separator 0.939319 ¶ 3853 3855 W2999253318.pdf 8 36 bibliography 0.9981633 "Brown, S., Santa Maria, J. P., Jr., & Walker, S. (2013). Wall teichoic acids of gram-positive bacteria. Annual Review of Microbiology, 67 ,1–28." 3855 4002 W2999253318.pdf 8 37 separator 0.9386771 ¶ 4002 4004 W2999253318.pdf 8 38 bibliography 0.9981114 "Chae, C. S., Kwon, H. K., Hwang, J. S., Kim, J. E., & Im, S. H. (2012). Prophylactic e ffect of probiotics on the development of experimental autoimmune myasthenia gravis. PloS One, 7 , e52119 ." 4004 4202 W2999253318.pdf 8 39 separator 0.93438613 ¶ 4202 4204 W2999253318.pdf 8 40 bibliography 0.998189 "De Castro, C., Parrilli, M., Holst, O., & Molinaro, A. (2010). Microbe-associated molecular patterns in innate immunity: Extraction and chemical analysis of gram-negative bacterial lipopolysaccharides. Methods in Enzymology, 480 ,8 9 –115." 4204 4448 W2999253318.pdf 8 41 separator 0.95399106 ¶ 4448 4450 W2999253318.pdf 8 42 bibliography 0.9941391 "Gerlach, D., Guo, Y., De Castro, C., Kim, S.-H., Schlatterer, K., Xu, F.-F., et al. (2018). Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature, 563 , 705 –709." 4450 4664 W2999253318.pdf 8 43 separator 0.9435111 ¶ 4664 4666 W2999253318.pdf 8 44 bibliography 0.9979517 "Górska, S., Schwarzer, M., Jachymek, W., Srutkova, D., Brzozowska, E., Kozakova, H., et al. (2014). Distinct immunomodulation of bone marrow-derived dendritic cell responses to Lactobacillus plantarum WCFS1 by two di fferent polysaccharides isolated from Lactobacillus rhamnosus LOCK 0900. Applied and Environmental Microbiology, 80 , 6506 –6516 ." 4666 5021 W2999253318.pdf 8 45 separator 0.9390121 ¶ 5021 5023 W2999253318.pdf 8 46 bibliography 0.9981287 Kang, C. S., Ban, M., Choi, E. J., Moon, H. G., Jeon, J. S., Kim, D. K., et al. (2013). 5023 5111 W2999253318.pdf 8 47 separator 0.49244416 5111 5112 W2999253318.pdf 8 48 bibliography 0.9916311 "¶ Extracellular vesicles derived from gut microbiota, especially Akkermansia mucini- phila, protect the progression of dextran sulfate sodium-induced colitis. Proceedings of the National Academy of Sciences of the USA, 8 , e76520 ." 5112 5347 W2999253318.pdf 8 49 separator 0.948156 ¶ 5347 5349 W2999253318.pdf 8 50 bibliography 0.99539304 "Kleerebezem, M., Hols, P., Bernard, E., Rolain, T., Zhou, M., Siezen, R. J., et al. (2010). The extracellular biology of the lactobacilli. FEMS Microbiology Reviews, 34 , 199 –230." 5349 5532 W2999253318.pdf 8 51 separator 0.92697185 ¶ 5532 5534 W2999253318.pdf 8 52 bibliography 0.9981133 Kwon, H. K., Lee, C. G., So, J. S., Chae, C. S., Hwang, J. S., Sahoo, A., et al. (2010). 5534 5623 W2999253318.pdf 8 53 separator 0.6367769 ¶ 5623 5625 W2999253318.pdf 8 54 bibliography 0.99778247 "Generation of regulatory dendritic cells and CD4+Foxp3+t cells by probiotics ad- ministration suppresses immune disorders. Proceedings of the National Academy of Sciences of the USA, 107 , 2159 –2164 ." 5625 5831 W2999253318.pdf 8 55 separator 0.93164873 ¶ 5831 5833 W2999253318.pdf 8 56 bibliography 0.9980979 "Lancefield, R. C. (1933). A serological di fferentiation of human and other groups of he- molytic streptococci. The Journal of Experimental Medicine, 57 , 571 –595." 5833 5998 W2999253318.pdf 8 57 separator 0.95102334 ¶ 5998 6000 W2999253318.pdf 8 58 bibliography 0.9978249 "Lee, I. C., Caggianiello, G., Swam, I. R. V., Taverne, N., Meijerink, M., Bron, P. A., et al. (2016). Strain-speci fic features of extracellular polysaccharides and their impact on Lactobacillus plantarum -Host interactions. Applied and Environmental Microbiology, 82 , 3959 –3970 ." 6000 6288 W2999253318.pdf 8 59 separator 0.9428973 ¶ 6288 6290 W2999253318.pdf 8 60 bibliography 0.9979975 "Prechtl, R. M., Wefers, D., Jacob, F., & Vogel, F. R. (2018). Structural characterization of the surface-associated heteropolysaccharide of Lactobacillus plantarum TMW 1.1478 and genetic analysis of its putative biosynthesis cluster. Carbohydrate Polymers, 202 , 236 –245." 6290 6569 W2999253318.pdf 8 61 separator 0.9471562 ¶ 6569 6571 W2999253318.pdf 8 62 bibliography 0.9980016 "Remus, D. M., Kranenburg, R. V., Swam, I. R. V., Taverne, N., Bongers, R. S., Wels, M., et al. (2012). Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling. Microbial Cell Factories, 11 , 149 –151." 6571 6845 W2999253318.pdf 8 63 separator 0.96090215 ¶ 6845 6847 W2999253318.pdf 8 64 bibliography 0.9980562 "Rocha-Ramírez, L. M., Pérez-Solano, R. A., Castañón-Alonso, S. L., Moreno Guerrero, S. S., Ramírez Pacheco, A., García Garibay, M., et al. (2017). Probiotic Lactobacillus strainsstimulate the in flammatory response and activate human macrophages. Journal of Immunological Research, 2017 , 4607491 ." 6847 7149 W2999253318.pdf 8 65 separator 0.94416094 ¶ 7149 7151 W2999253318.pdf 8 66 bibliography 0.99800533 "Sanchez, J. I., Mart ınez, B., Guillen, R., enez-D ıaz, R. F., & Rodr ıguez, A. (2006). Culture conditions determine the balance between two di fferent exopolysaccharides pro- duced by Lactobacillus pentosus LPS26. Applied and Environmental Microbiology, 72 , 7495 –7502 ." 7151 7429 W2999253318.pdf 8 67 separator 0.94828296 ¶ 7429 7431 W2999253318.pdf 8 68 bibliography 0.9980618 "Sechenkova, S. N., Perepelov, A. V., Cedzynski, M., Swierzko, A., Ziolkowski, A., Shashkov, A. S., et al. (2004). Structure of a highly phosphorylated O-polysaccharide ofProteus mirabilis O41. Carbohydrate Research, 339 , 1347 –1352 ." 7431 7670 W2999253318.pdf 8 69 separator 0.96180654 ¶ 7670 7672 W2999253318.pdf 8 70 bibliography 0.9958059 "Shashkov, A. S., Potekina, N. V., Senchenkova, S. N., & Kudryashova, E. B. (2009). Anionic polymers of the cell wall of Bacillus subtilis subsp. Subtilis VKM B-501. Biochemistry (Moscow), 74 , 543 –548." 7672 7879 W2999253318.pdf 8 71 separator 0.9533586 ¶ 7879 7881 W2999253318.pdf 8 72 bibliography 0.99454504 "Speciale, I., Verma, R., Di Lorenzo, F., Molinaro, A. B., Im, S. H., & De Castro, C. (2019). Bifidobacterium bi fidumpresents on the cell surface a complex mixture of glucans and galactans with di fferent immunological properties. Carbohydrate Polymers, 218 , 269 –278." 7881 8157 W2999253318.pdf 8 73 separator 0.94977343 ¶ 8157 8159 W2999253318.pdf 8 74 bibliography 0.9980421 "Streshinskaya, G. M., Shashkov, A. S., Potekhina, N. V., Kozlova, Y. I., Tul ’skaya, E. M., Senchenkova, S. N., et al. (2011). Carbohydrate-containing cell wall polymers of some strains of the Bacillus subtilis group. Microbiology, 80 ,2 1 –29." 8159 8408 W2999253318.pdf 8 75 separator 0.9549671 ¶ 8408 8410 W2999253318.pdf 8 76 bibliography 0.998007 "Telesford, K. M., Yan, W., Ochoa-Reparaz, J., Pant, A., Kircher, C., Christy, M. A., et al. (2015). A commensal symbiotic factor derived from Bacteroides fragilis promotes human CD39(+)Foxp3(+) T cells and Treg function. Gut Microbes, 6 , 234 –242." 8410 8663 W2999253318.pdf 8 77 separator 0.96319973 ¶ 8663 8665 W2999253318.pdf 8 78 bibliography 0.9958799 "Tomita, S., Furihata, K., Nukada, T., Satoh, E., Uchimira, T., & Okada, S. (2009). Structures of two monomeric units of teichoic acid prepared from the cell wall of Lactobacillus plantarum NRIC 1068. Bioscience, Biotechnological, and Biochemistry, 73 , 530 –535." 8665 8934 W2999253318.pdf 8 79 separator 0.9517262 ¶ 8934 8936 W2999253318.pdf 8 80 bibliography 0.9979407 "Tomita, S., Tanaka, N., & Okada, S. (2017). A rapid method-based for discrimination of strain-speci fic cell wall teichoic acid structures reveals a third backbone type in Lactobacillus plantarum .FEMS Microbiology Letters, 364 ,1–10." 8936 9174 W2999253318.pdf 8 81 separator 0.9611167 ¶ 9174 9176 W2999253318.pdf 8 82 bibliography 0.9978485 "Torriani, S., Felis, G. E., & Dellaglio, F. (2001). Di fferentiation of Lactobacillus plantarum , L. pentosus , and L. paraplantarum by recA gene sequence analysis and multiplex PCR assay with recA gene-derived primers. Applied and Environmental Microbiology, 67 (8), 3450 –3454 ." 9176 9462 W2999253318.pdf 8 83 separator 0.95413184 ¶ 9462 9464 W2999253318.pdf 8 84 bibliography 0.9980359 "Toukach, P. V., & Egorova, K. S. (2016). Carbohydrate structure database merged from bacterial, archaeal, plant and fungal parts. Nucleic Acids Research, 44 (D1), D1229– D1236." 9464 9645 W2999253318.pdf 8 85 separator 0.9376681 ¶ 9645 9647 W2999253318.pdf 8 86 bibliography 0.9980926 "Valueva, O. A., Shashkov, A. S., Zdorovenko, E. L., Chizhov, A. O., Kiseleva, E., Novik, G., et al. (2013). Structures of cell-wall phosphate-containing glycopolymers of Bifidobacterium longum BIM B-476-D. Carbohydrate Research, 373 ,2 2 –27." 9647 9893 W2999253318.pdf 8 87 separator 0.96101815 ¶ 9893 9895 W2999253318.pdf 8 88 bibliography 0.99803036 "Verma, R., Lee, C., Jeun, E. J., Yi, J., Kim, K. S., Ghosh, A., et al. (2018). Cell surface polysaccharides of Bifidobacterium bi fidum induce the generation of Foxp3+ reg- ulatory T cells. Science Immunology, 19 (3(28)) ." 9895 10120 W2999253318.pdf 8 89 separator 0.94059074 ¶ 10120 10122 W2999253318.pdf 8 90 bibliography 0.9979835 "Zeidan, A. A., Poulsen, V. K., Janzen, T., Buldo, P., Derkx, P. M. F., Øregaard, G., et al. (2017). Polysaccharide production by lactic acid bacteria: From genes to industrial applications. FEMS Microbiology Reviews, 41 , S168 –S200 .P. Garcia-Vello, et al. Carbohydrate Polymers 233 (2020) 115857" 10122 10424 W2999253318.pdf 8 91 separator 0.9769598 ¶ 10424 10426 W2999253318.pdf 8 92 bibliography 0.7102758 9 10426 10428 W2999253318.pdf 8 0 paratext 0.99003375 Electronics 2020 ,9, 2053 8 of 14 0 33 W3108716743.pdf 7 1 separator 0.9946127 ¶ 33 35 W3108716743.pdf 7 2 title 0.98650295 Table 2. Details of the datasets used in experiments. 35 89 W3108716743.pdf 7 3 separator 0.9944101 ¶ 89 91 W3108716743.pdf 7 4 table 0.9941832 "Size Dataset Type Num Type Num 3232M-A mHDR 30k iHDR-A 30k M-H mHDR 30k iHDR-H 30k M-K mHDR 30k iHDR-K 30k M-U mHDR 30k iHDR-U 30k 6464M-A mHDR 30k iHDR-A 30k M-H mHDR 30k iHDR-H 30k M-K mHDR 30k iHDR-K 30k M-U mHDR 30k iHDR-U 30k 128128M-A mHDR 30k iHDR-A 30k M-H mHDR 30k iHDR-H 30k M-K mHDR 30k iHDR-K 30k M-U mHDR 30k iHDR-U 30k" 91 451 W3108716743.pdf 7 5 separator 0.995276 ¶ 451 453 W3108716743.pdf 7 6 title 0.9938477 4.1.2. Implementation of the CNN 453 486 W3108716743.pdf 7 7 separator 0.9957999 ¶ 486 488 W3108716743.pdf 7 8 text 0.99946666 "The DCT-CNN for HDR source forensics is implemented with the Pytorch deep learning framework [ 37]. Experiments were carried out on a high-performance computer with IntelrCoreTM i7-9800X (3.80 GHz) (Intel, Santa Clara, CA, USA), 64 GB RAM and NVIDIArGEFORCE RTX 2080 Ti GPU (NVIDIA, Santa Clara, CA, USA). The parameters of the network are set as follows. The initial learning rate with a learning rate decay strategy is set to 0.001. The batch size is set to 64 images, the loss function is cross-entropy loss, and the optimizer is Adam [ 38]. Classification accuracy (Acc) is used to evaluate the performance of forensics methods. We chose LHS [ 19], SPAM [ 20], HOG [ 21], HDR-CNN [22], RF-CNN [24] and MISL-net [27] as comparative methods." 488 1245 W3108716743.pdf 7 9 separator 0.9970677 ¶ 1245 1247 W3108716743.pdf 7 10 title 0.99399287 4.2. Forensics on Images without Anti-Forensics Attack 1247 1302 W3108716743.pdf 7 11 separator 0.99616724 ¶ 1302 1304 W3108716743.pdf 7 12 text 0.99958384 "The classification accuracy averaged over the test datasets with a resolution of 3232are summarized in Table 3 for all the tested methods. The best results are marked in bold. Since small-size images include less information related to forensics, experiments conducted on small-size images can reflect the feature extraction capability of forensic methods. Table 3 indicates that the performance of HDR source forensics using manually specified feature extraction methods is weaker than using CNN-based methods to extract features automatically. For instance, the highest classification accuracy of LHS is 88.59 %on the M-A dataset, while the accuracy of the two CNN-based forensic methods reached 94.62 %and 98.94 %. For CNN-based forensic methods, the performance of DCT-CNN in the frequency domain is better than HDR-CNN in the spatial domain. This result validates that the decorrelation of DCT helps CNN extract the most important features related to HDR source forensics." 1304 2297 W3108716743.pdf 7 13 separator 0.84732175 ¶ 2297 2299 W3108716743.pdf 7 14 text 0.9995607 In this experiment, the proposed DCT-CNN manifests the best performance on different HDR datasets. 2299 2398 W3108716743.pdf 7 15 separator 0.8004528 ¶ 2398 2400 W3108716743.pdf 7 16 text 0.99797434 "For the proposed DCT-CNN, classification accuracy increased by 10.35 %compared with the manually specified feature extraction methods. In addition, compared with HDR-CNN which is a CNN-based forensics method built the spatial domain, the forensics accuracy increased by 4.32 %. The experimental results validate that the proposed DCT-CNN for HDR source forensics which is built in the DCT domain can achieve desired forensic performance on 3232images. It can be observed from Table 3 that compared with other methods, the proposed DCT-CNN gained the highest AUC on different datasets. Figure 5 shows the ROC of different methods, the curve of the DCT-CNN proposed in this paper is closer to the point (0, 1), which indicates that DCT-CNN has better forensics performance over other methods." 2400 3206 W3108716743.pdf 7 0 text 0.9975835 "The results of the multiple conditional logistic regression assessing the risk of TKA peri- prosthetic infection associated with cumulative episodes of dental scaling, conditional on allbaseline characteristics, are shown in Table 2 . The primary analysis revealed that patients who had received dental scaling had a 20% lower risk for infection than patients who never received this procedure (adjusted OR, 0.80; 95% confidence interval (CI), 0.68 –0.93). We further classi- fied the frequency at which patients received dental scaling into 1 –4 times and 5 –6 times. Com- pared with patients who never received dental scaling, patients who had received dental scaling 1–4 times had an OR of 0.84 (95% CI, 0.71 –0.99). Moreover, an even lower OR of 0.69 was observed for patients who had received regular dental scaling (95% CI, 0.52 –0.89). The results suggested that the more frequently patients underwent dental scaling, the lower their risk of infection." 0 977 W2469933197.pdf 3 1 separator 0.99611014 ¶ 977 979 W2469933197.pdf 3 2 title 0.9822688 Discussion 979 990 W2469933197.pdf 3 3 separator 0.9959494 ¶ 990 992 W2469933197.pdf 3 4 text 0.99950844 The most important finding of this population-based nested case-control study was that fre-quent dental checkups and tooth scaling may reduce the risk of TKA infection. The risk was 992 1174 W2469933197.pdf 3 5 title 0.8975507 "Table 1. Baseline characteristics of patients older than 40 years who had undergone TKA from 1999 to 2002 from the Taiwan National Health Insur- ance Research Database with and without periprosthetic infection within 5 years." 1174 1401 W2469933197.pdf 3 6 separator 0.95993793 ¶ 1401 1403 W2469933197.pdf 3 7 table 0.986692 "Periprosthetic infection *(N = 1,251) Control (N = 5,004) Mean age (SD) 69.1 (8.0) 69.3 (7.6) Calendar year (%) 1999 26.1 23.8 2000 26.1 21.2 2001 23.7 22.3 2002 24.1 32.7 Past medical history (%) Osteoarthritis 87.9 88.6 Rheumatoid arthritis 10.2 7.4 Gout 17.9 15.2 Diabetes mellitus 27.3 19.3 Ischemic heart diseases 22.5 19.2 Hypertension 51.8 50.3 Peripheral vascular disease 1.1 0.8 Comorbid condition (%) Heart failure 7.0 6.5 Chronic lung disease 22.8 20.1 Hyperlipidemia 15.4 16.1 Ischemic stroke 4.4 4.1 Transient ischemic attack 2.1 1.5 Osteoporosis 21.3 19.4 Gingival and periodontal diseases 17.4 20.2 Cumulative episodes of dental scaling over a 3-year period (%) ** 0 73.1 67.8 1–4 19.7 22.4 5–6 7.1 9.9 *NHI surgery codes (64198B, Removal of prostheses) and concomitant use of systemic antibiotics for at least 7 days **NHI procedure codes (91003C, 91004C)" 1403 2333 W2469933197.pdf 3 8 separator 0.957686 ¶ 2333 2335 W2469933197.pdf 3 9 paratext 0.9369865 doi:10.1371/journal.pone.0158096.t001 2335 2373 W2469933197.pdf 3 10 separator 0.9359626 ¶ 2373 2375 W2469933197.pdf 3 11 title 0.95518863 Dental Scaling and Reduced Risk of TKA Infection 2375 2424 W2469933197.pdf 3 12 paratext 0.9436108 ¶ PLOS ONE | DOI:10.1371/journal.pone.0158096 June 23, 2016 4/8 2424 2488 W2469933197.pdf 3 0 text 0.9989281 "ConnectE ( Zhao et al. ,2020 ) jointly embeds enti- ties and types into two different spaces and learns a mapping from the entity space to the type space." 0 158 W4385573235.pdf 2 1 separator 0.90598196 ¶ 158 160 W4385573235.pdf 2 2 text 0.9995346 "CORE ( Ge et al. ,2021 ) utilizes the models Ro- tatE ( Sun et al. ,2019 ) and ComplEx ( Trouillon et al. ,2016 ) to embed entities and types into two different complex spaces, and develops a regression model to link them. However, the above methods do not fully consider the known types of entities while training the entity embedding representation, which seriously affects the prediction performance of missing types. Also, the representation of types in these methods is such that they cannot be se- mantically differentiated. CET ( Pan et al. ,2021 ) jointly utilizes information about existing type as- sertions in a KG and about the neighborhood of entities by respectively employing an independent- based mechanism and an aggregated-based one. It also utilizes a pooling method to aggregate their inference results. AttEt ( Zhuo et al. ,2022 ) designs an attention mechanism to aggregate the neighbor- hood knowledge of an entity using type-specific weights, which are beneficial to capture specific characteristics of different types. A shortcoming of these two methods is that, unlike our TET model, they are not able to cluster types in classes, and are thus not able to semantically differentiate them in a fine-grained way." 160 1441 W4385573235.pdf 2 3 separator 0.9919245 ¶ 1441 1443 W4385573235.pdf 2 4 text 0.99946153 "GCN-based Methods. Graph Convolutional Net- works (GCNs) have proven effective on modeling graph structures ( Kipf and Welling ,2017 ;Hamil- ton et al. ,2017 ;Dettmers et al. ,2018 ). However, directly using GCNs on KGs usually leads to poor performance since KGs have different kinds of entities and relations. To address this problem, RGCN ( Schlichtkrull et al. ,2018 ) proposes to ap- ply relation-specific transformations in GCN’s ag- gregation. HMGCN ( Jin et al. ,2019 ) proposes a hierarchical multi-graph convolutional network to embed multiple kinds of semantic correlations be- tween entities. CompGCN ( Vashishth et al. ,2020 ) uses composition operators from KG-embedding methods by jointly embedding both entities and relations in a relational graph. ConnectE-MRGAT (Zhao et al. ,2022 ) proposes a multiplex relational graph attention network to learn on heterogeneous relational graphs, and then utilizes the ConnectE method for infering entity types. RACE2T ( Zou et al.,2022 ) introduces a relational graph attention network method, utilizing the neighborhood and relation information of an entity for type inference.A common problem with these methods is that they follow a simple single-layer attention formulation, restricting the information transfer between uncon- nected neighbors of an entity." 1443 2810 W4385573235.pdf 2 5 separator 0.99442345 ¶ 2810 2812 W4385573235.pdf 2 6 text 0.99910426 "Transformer-based Methods. To the best of our knowledge, there are no transformer-based approaches to KGET. However, two transformer- based frameworks for the KGC task have been al- ready proposed: CoKE ( Wang et al. ,2019 ) and HittER ( Chen et al. ,2021 ). Our experiments show that they are not suitable for KGET." 2812 3141 W4385573235.pdf 2 7 separator 0.99660194 ¶ 3141 3143 W4385573235.pdf 2 8 title 0.98955196 3 Method 3143 3152 W4385573235.pdf 2 9 separator 0.9962158 ¶ 3152 3154 W4385573235.pdf 2 10 text 0.9992093 "In this section, we describe the architecture of our TET model (cf. Figure 2). We start by introducing necessary background (Sec. 3.1), then present in detail the architecture of TET (Sec. 3.2). Finally, we describe pooling and optimization strategies (Sec. 3.3and3.4)." 3154 3434 W4385573235.pdf 2 11 separator 0.99735177 ¶ 3434 3436 W4385573235.pdf 2 12 title 0.98828197 3.1 Background 3436 3451 W4385573235.pdf 2 13 separator 0.9933995 ¶ 3451 3453 W4385573235.pdf 2 14 text 0.9995215 "In this paper, a knowledge graph ( Pan et al. ,2016 ) is represented in a standard format for graph- structured data such as RDF ( Pan,2009 ). Aknowl- edge graph (KG) Gis a tuple (E,R,C,T), where Eis a set of entities, Cis a set of entity types, R is a set of relation types, and Tis a set of triples." 3453 3765 W4385573235.pdf 2 15 separator 0.95528233 ¶ 3765 3767 W4385573235.pdf 2 16 text 0.99903834 "Triples in Tare either relation assertions (h, r, t ) where h, t∈ Eare respectively the head andtail entities of the triple, and r∈ R is the edge of the triple connecting head and tail; or entity type as- sertions (e,has_type , c), where e∈ E,c∈ C, and has_type is the instance-of relation. For e∈ E, therelational neighbors of eis the set {(r, f)| (e, r, f )∈ T } . The type neighbors of eare defined as{(has_type , c)|(e,has_type , c)∈ T } . We will simply say neighbors of ewhen we refer to the relational and type neighbors of e. The goal of this paper is to address KGET task which aims at infer- ring missing types from Cin entity type assertions." 3767 4444 W4385573235.pdf 2 17 separator 0.9970124 ¶ 4444 4446 W4385573235.pdf 2 18 title 0.99250335 3.2 Model Architecture 4446 4469 W4385573235.pdf 2 19 separator 0.9965334 ¶ 4469 4471 W4385573235.pdf 2 20 text 0.99856067 "In this section, we introduce the local, global and context transformer-based modeling components of our TET model. Before defining these components, we start by discussing an important observation." 4471 4675 W4385573235.pdf 2 21 separator 0.9966076 ¶ 4675 4677 W4385573235.pdf 2 22 title 0.9918436 3.2.1 Class Membership 4677 4700 W4385573235.pdf 2 23 separator 0.9956935 ¶ 4700 4702 W4385573235.pdf 2 24 text 0.99940497 "A key observation is that in a KG alltype assertions are uniformly defined using the relation has_type .5990" 4702 4812 W4385573235.pdf 2 0 paratext 0.9798925 "p-ISSN 2083 -0157, e -ISSN 2391 -6761 IAPGOŚ 3/2023 125 artykuł recenzowany/revised paper IAPGOS, 3/2023 , 125–128 http://doi.org/10.35784/iapgos. 5351 received: 26.07.2023 | revised: 10.09.2023 | accepted: 28.09.2023 | available online: 30.0 9.2023" 0 267 W4387215075.pdf 0 1 separator 0.9880917 ¶ 269 271 W4387215075.pdf 0 2 title 0.9788619 "ENGINEERING AND TECH NICAL ASSESSMENT OF THE COMPETITIVENE SS OF UKRAINIAN MECHANICAL" 271 361 W4387215075.pdf 0 3 separator 0.5000061 363 364 W4387215075.pdf 0 4 title 0.96563303 "¶ ENGINEERING ENTERPRI SES BASED ON THE APPLICATION OF REGRESSION MODELS" 364 440 W4387215075.pdf 0 5 separator 0.99470663 ¶ 442 444 W4387215075.pdf 0 6 contact 0.97368735 "Anna Vitiuk1, Leonid Polishchuk2, Nataliia B. Savina3, Oksana O. Adler1, Gulzhan Kashaganova4, Saule Kumargazhanova5" 444 564 W4387215075.pdf 0 7 separator 0.9459883 ¶ 565 567 W4387215075.pdf 0 8 contact 0.9842002 "1Vinnytsia National Technical University, Department of Management, Marketing and Economy, Vinnytsia, Ukraine, 2Vinnytsia National Tech nical University, Department of Industrial Engineering , Vinnytsia, Ukraine , 3National University of Water and Environmental Engineering, Rivne, Ukraine , 4Turan University, Faculty of Digital Technolog ies and Art, Department of Computer and Software Engineering, Almaty, Kazakhstan, 5D. Serikbayev East Kazakhstan Technical University, Department of Information Technologies and Intelligent Systems, Ust-Kamenogorsk, Kazakhstan" 567 1148 W4387215075.pdf 0 9 separator 0.9926965 ¶ 1150 1152 W4387215075.pdf 0 10 text 0.9993746 "Abstract. The characteristic features of engineering products are revealed. Average industry performance indicators of mechanical engineering enterprises in Ukraine were formed. The competitiveness of mechanical engineering enterprises was studied. The integral indicator of the competitiveness of mechanical engineering enterprises in Ukraine was evaluated. It has been established that the competitiveness industry, de spite certain profits received by enterprises, is in a systemic, predictable crisis and only individual enterprises that maintain their own line of economic behavior are successful, increase competitiveness and have prospects for further economic growth ." 1152 1848 W4387215075.pdf 0 11 separator 0.98185873 ¶ 1849 1851 W4387215075.pdf 0 12 text 0.92997664 Keywords: competitiveness, regression, mechanical engineering, dependence 1851 1926 W4387215075.pdf 0 13 separator 0.9959117 ¶ 1928 1930 W4387215075.pdf 0 14 title 0.9826369 "INŻYNIERYJNO -TECHNICZNA OCENA KON KURENCYJNOŚCI UKRAIŃ SKICH PRZEDSIĘBIORSTW BUDO WY MASZYN NA PODSTAW IE ZASTOSOWANIA MODELI REGRESJI" 1930 2073 W4387215075.pdf 0 15 separator 0.99586093 ¶ 2075 2077 W4387215075.pdf 0 16 text 0.99873084 "Streszczenie. Ujawniono charakterystyczne cechy produktów inżynieryjnych. Opracowano średnie wskaźniki wydajności przemysłu przedsiębiorstw inżynierii mechanicznej na Ukrainie. Zbadano konkurencyjność przedsiębiorstw przemysłu maszynowego. Oceniono integralny wskaź nik konkurencyjności przedsiębiorstw przemysłu maszynowego na Ukrainie. Ustalono, że branża konkurencyjności, pomimo pewnych zysków uzyskiwanych p rzez przedsiębiorstwa, znajduje się w systemowym, przewidywalnym kryzysie i tylko pojedyncze przedsiębiorstwa, któ re utrzymują własną linię zachowań gospodarczych, odnoszą sukcesy, zwiększają konkurencyjność i mają perspektywy dalszego wzrostu gospodarczego." 2077 2764 W4387215075.pdf 0 17 separator 0.9649353 ¶ 2766 2768 W4387215075.pdf 0 18 text 0.945174 Słowa kluczowe: konkurencyjność, regresja, inżynieria mechaniczna, zależność 2768 2846 W4387215075.pdf 0 19 separator 0.99680436 ¶ 2848 2850 W4387215075.pdf 0 20 title 0.8065364 Introduction 2850 2863 W4387215075.pdf 0 21 separator 0.9879027 ¶ 2865 2867 W4387215075.pdf 0 22 text 0.9995202 "A feature of mechanical engineeri ng enterprises is the provision of fixed assets for other enterprises, the consequence of which is the further development of other branches of the economy. Therefore, ensuring the active development of mechanical engineering enterprises should be based on the maximum possible use of the conditions of spatial potential: chaotic and systemic trends in the development of the economy, the main directions of development of the corresponding enterprise s, infrastructure connectivity, economic t ies and partnership relations [ 10]. In such circumstances, the management of the enterprise, which involves the use of optimal resource provision, rational location of production, development of integration processes and ensuring the effective distribution of tasks will ensu re the competitiveness of mechanical engineering enterprises [1, 13]." 2867 3797 W4387215075.pdf 0 23 separator 0.99760675 ¶ 3798 3800 W4387215075.pdf 0 24 title 0.98986816 1. Formulation of the problem 3800 3830 W4387215075.pdf 0 25 separator 0.9927963 ¶ 3832 3834 W4387215075.pdf 0 26 text 0.9995887 "Mechanical engineering is a basic branch of economic development in every country, however, each country has its own conditions and prospects for the developme nt of machine -building industries. The fact remains indisputable that, in order to ensure progressive development, product manufacturers are forced to enter into a competitive struggle for better operating conditions." 3834 4229 W4387215075.pdf 0 27 separator 0.60594046 ¶ 4230 4232 W4387215075.pdf 0 28 text 0.9996294 "The result of the progressive developm ent of society was the emergence and formation of the phenomenon of competition, which forces product manufacturers to constantly move and improve themselves, not to stop at the achieved results, that is, to increase their competitiveness [2, 4]. Competiti veness is the most important criterion for the expediency of an enterprise's activity, a condition for the efficiency of production activity, the basis for choosing means and methods of management, and a guarantee of success in competition [7, 11 ]." 4232 4810 W4387215075.pdf 0 29 title 0.9925764 2. Results of the research and discussion 4810 4853 W4387215075.pdf 0 30 separator 0.99480736 ¶ 4855 4857 W4387215075.pdf 0 31 text 0.99970293 "Having established the competitiveness of the enterprise as the most general characteristic of the development of the enterprise, we will evaluate the indicator according to the methodology presented by O. Kuzmin, O. Melnyk and O. Romanko [ 4] where the main emphasis is placed on highlighting competitiveness through indicators of financial and economic efficiency, indicators of production efficiency and indicators of commercial efficiency. The peculiarity of the method is taki ng into account the share of defective products that are manufactured and the presence of which can distort the further production process. In order to identify the share of defects in the manufacture of mechanical engineering products, it is important to take into account the complexity of the manufactured products." 4857 5713 W4387215075.pdf 0 32 separator 0.9789541 ¶ 5715 5717 W4387215075.pdf 0 33 text 0.99411815 "The work of O. Danchenko, O. Zanora , V. Borkun [3] presents results where the share of defects in the manufacture of mechanical engineering products of various precision was clearly established. It has been proven that in the process of precise processing there is a defect, the costs of which are 2% of the total cost of processing blanks in the case of processing according to the 8th quality and 17% of the cost – according to the 7th quality. With a further increase in the accuracy of processing to the 6th quality, the cost of defects reaches 32% of the cost of processing blanks . Therefore, let's assume the following levels of shortage for the industries: agricultural, nuclear, electri cal engineering, heavy and transport, construction, road and utility engineering, engineering for light and food industry, animal husbandry and fodder production – 2%; machine - tool, tool, chemical, petroleum and power engineering – 17%; instrumentation, pr oduction of automation and control equipment (32%). We will use 17% of defects of the total cost of processing blanks for researched enterprises [2, 14 ]." 5717 6895 W4387215075.pdf 0 0 paratext 0.9890104 Sensors 2008 ,8 7555 0 20 W2092892698.pdf 10 1 separator 0.9937297 ¶ 20 22 W2092892698.pdf 10 2 text 0.99312013 "that detected the strongest signal intensity. To this end, we have devised an empiric relationship between the ADC values and the distance when the emitter and receiver sensors are facing each other as shown in Figure 11a. As the receiver sensors have a maximum sensibility angle at ¡3±which decreases according to Figure 11b, the relationship between the ADC values and the distance must be extended to a 3D graph as shown in Figure 12. Following this graph, we calculate the estimated distances e1⁄2max 1ande1⁄2max 2 from the emitter to each of the two maximum sensors from the received ADC values bomax 1andbomax 2 respectively." 22 662 W2092892698.pdf 10 3 separator 0.99571973 ¶ 662 664 W2092892698.pdf 10 4 caption 0.9966144 "Figure 11. (a) Reception values for different distance transmissions when emitter and re- ceiver sensors are facing each other. (b) Radiation diagram for the PIN diode of the peak detector. (Obtained from the PD100MF0MPx Datasheet)." 664 901 W2092892698.pdf 10 5 separator 0.5148678 ¶ 901 903 W2092892698.pdf 10 6 caption 0.9930422 (a) (b) 903 911 W2092892698.pdf 10 7 separator 0.9784102 ¶ 911 913 W2092892698.pdf 10 8 caption 0.9962878 Figure 12. Reception values for different distance and angle transmissions. 913 989 W2092892698.pdf 10 9 separator 0.9934066 ¶ 989 991 W2092892698.pdf 10 10 text 0.9946971 Applying the law of cosines, we devise a relationship to calculate two estimated distances ̧max ifrom 991 1093 W2092892698.pdf 10 0 title 0.60266566 Short 0 5 W2103630446.pdf 0 1 separator 0.62314296 ¶ 5 7 W2103630446.pdf 0 2 title 0.98479414 "CommunicationA single amino acid substitution in the V protein of Nipah virus alters its ability to block interferon signalling in cells from different species" 7 171 W2103630446.pdf 0 3 separator 0.9888303 ¶ 171 173 W2103630446.pdf 0 4 contact 0.979396 "Kathrin Hagmaier,1Nicola Stock,13Steve Goodbourn,2Lin-Fa Wang3 and Richard Randall1" 173 259 W2103630446.pdf 0 5 separator 0.5663434 ¶ 259 261 W2103630446.pdf 0 6 contact 0.9907956 "Correspondence Richard Randallrer@st-andrews.ac.uk1Centre for Biomolecular Sciences, University of St Andrews, The North Haugh, St Andrews KY16 9ST, UK 2Division of Basic Medical Sciences, St George’s, University of London, London SW17 0RE,UK 3CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, VIC 3220,Australia" 261 606 W2103630446.pdf 0 7 separator 0.97653234 ¶ 606 608 W2103630446.pdf 0 8 paratext 0.90633327 "Received 1 June 2006 Accepted 1 August 2006" 608 654 W2103630446.pdf 0 9 text 0.9993486 "The V protein of the paramyxovirus Nipah virus (NiV) has been shown to antagonize the interferon (IFN) response in human cells via sequestration of STAT1 and STAT2. This study describes a mutant of the NiV V protein, referred to as V(AAHL), that is unable to antagonize IFN signalling and demonstrates that a single amino acid substitution is responsible for its inactivity. The molecularbasis for this was identified as a failure to interact with STAT1 and STAT2. It was also shown that NiV V, but not V(AAHL), was functional as an IFN antagonist in human, monkey, rabbit, dog, horse, pig and bat cells, which suggests that the ability of NiV to block IFN signalling is not a majorconstraint that prevents this virus from crossing species barriers." 654 1412 W2103630446.pdf 0 10 separator 0.9825907 ¶ 1412 1414 W2103630446.pdf 0 11 text 0.9995844 "In the last decade, zoonotic outbreaks of respiratory disease and encephalitis affecting humans, horses and pigs inAustralia, Malaysia and Singapore have led to the isolationof two novel paramyxoviruses, Hendra virus (HeV) and Nipah virus (NiV) (Chua et al. , 2000; Murray et al. , 1995; O’Sullivan et al. , 1997). However, due to characteristic differences from other paramyxoviruses they have been assigned to a new genus, Henipavirus (Wang et al. , 2000)." 1414 1883 W2103630446.pdf 0 12 separator 0.96978635 ¶ 1883 1885 W2103630446.pdf 0 13 text 0.9997268 "The natural hosts of both HeV and NiV are fruit bats(suborder Megachiroptera) of the genus Pteropus (Chua et al. , 2002; Halpin et al. , 2000). Neutralizing antibodies to NiV have also been found in an insectivorous bat (suborderMicrochiroptera) (Yob et al. , 2001). In the initial HeV and NiV outbreaks, the viruses were transmitted from bats tohumans by way of intermediate animal hosts, horses andpigs, respectively (Chua et al. , 2000). More recent outbreaks of NiV in Bangladesh and India have led to further humandeaths and may have been a result of both bat-to-human andhuman-to-human transmissions (Butler, 2004; Chadhaet al. , 2006; Enserink, 2004; Hsu et al. , 2004)." 1885 2571 W2103630446.pdf 0 14 separator 0.9828998 ¶ 2571 2573 W2103630446.pdf 0 15 text 0.99948615 "Similar to other paramyxoviruses, both henipaviruses have the potential to express multiple proteins, P, V, W and C,from the P gene by RNA editing and alternative translationalinitiation (reviewed by Lamb & Kolakofsky, 2001). The Vand/or C proteins of various paramyxoviruses have been demonstrated to antagonize the interferon (IFN) system,part of the innate cellular immune response to viral infection, in several distinct ways (for recent reviews, see Horvath, 2004; Nagai & Kato, 2004; Stock et al. , 2005). NiV and HeV antagonize both IFN- a/band IFN- csignalling via the binding and sequestration of STAT1 and STAT2 in high- molecular-mass complexes (Rodriguez et al. , 2002, 2003). In other paramyxoviruses, the highly conserved cysteine-rich Cterminus of the V protein is required to antagonize IFN signalling, but although henipavirus V proteins share this conserved C-terminal domain, it is dispensable forthe sequestration of STAT1 and STAT2 by these viruses (Rodriguez et al. , 2004; Shaw et al. , 2004). The regions of NiV V that interact with STAT1 and STAT2 have been mapped tothe N terminus of the protein, from residues 100 to 160 forSTAT1 binding and a larger region comprising residues 100–300 for STAT2 binding (Rodriguez & Horvath, 2004; Rodriguez et al. , 2004). A similar study by Shaw et al. (2004) identified an overlapping area, residues 50–150, as sufficient for binding of STAT1 (Shaw et al. , 2004). These regions are also present in the NiV P and W proteins, both of which havebeen demonstrated to block IFN- a/bsignalling and to bind STAT1 (Rodriguez et al. , 2002; Shaw et al. , 2004). The P, V and W proteins of NiV, as well as the C protein, which has asequence distinct from other P gene products as a result ofalternative translational initiation, also antagonize the IFN response in chicken cells (Park et al. , 2003)." 2573 4471 W2103630446.pdf 0 16 separator 0.9903321 ¶ 4471 4473 W2103630446.pdf 0 17 contact 0.8258779 "3Present address: Howard Hughes Medical Institute, Northwestern University, Evanston, IL 60208-3500, USA." 4473 4581 W2103630446.pdf 0 18 separator 0.9011166 ¶ 4581 4583 W2103630446.pdf 0 19 paratext 0.9840054 0008-2261 G2006 SGM Printed in Great Britain 3649Journal of General Virology (2006), 87, 3649–3653 DOI 10.1099/vir.0.82261-0 4583 4708 W2103630446.pdf 0 0 title 0.95255214 Table I: Successive decoding order at the receivers. 0 52 W4287754183.pdf 3 1 separator 0.9948461 ¶ 52 54 W4287754183.pdf 3 2 title 0.58630276 Receiver 54 63 W4287754183.pdf 3 3 table 0.76242566 Stage 1 Stage 2 Stage 3 Stage 4 Stage 5 Stage 6 Stage 7 Stage 8 Stage 9 63 135 W4287754183.pdf 3 4 separator 0.8443744 ¶ 135 137 W4287754183.pdf 3 5 table 0.972752 "Yi 1Vi 1Vj 1Vi 2Vi 3Ui 1 Yi 2Vi 1Vj 1Vi 2Vj 2Vi 3Ui 1Ui 2 Yi 3Vj 1Vi 1Vj 2Vi 2Vj 3Vi 3Ui 1Ui 2Ui 3" 137 291 W4287754183.pdf 3 6 separator 0.9962548 ¶ 291 293 W4287754183.pdf 3 7 title 0.99287945 A. Average Rate region 293 316 W4287754183.pdf 3 8 separator 0.99623054 ¶ 316 318 W4287754183.pdf 3 9 text 0.9816349 "An achievable rate region is defined as the set of achievable rates of the codebooks fVi k;Ui kg3 k=1;8i2f1;2g. The achiev- able rate of codebook Vi k(Ui k)is bounded by the minimum achievable rate at the receivers in the set Dvi k(Dui k), where the successive decoding order at each receiver is outlined in Table I. We denote the rates of codebooks Vi kandUi kbyRvi kandRui k, respectively. Similarly, we denote the power fractions of the total power Piallocated to codebooks Vi kandUi kby vi kand ui k, respectively. Finally, we define Ri( j; k)as the total achievable rate for user iin the channel state ( j; k)and define Ri4=E[Ri( j; k)]as the average achievable rate at receiveri, where the expectation is taken with respect to the combined channel states distribution. The average achievable rate region is formally characterized in Theorem 1." 318 1221 W4287754183.pdf 3 10 separator 0.99373794 ¶ 1221 1223 W4287754183.pdf 3 11 caption 0.78876257 "Theorem 1. In the two-state channel, the average achievable rate region corresponding to the layering scheme in Fig. 2" 1223 1344 W4287754183.pdf 3 12 separator 0.5494463 ¶ 1344 1346 W4287754183.pdf 3 13 text 0.87747693 "and the decoding order in Table I encloses the set of rates fRvi" 1346 1413 W4287754183.pdf 3 14 math 0.53865767 ¶ 1413 1415 W4287754183.pdf 3 15 text 0.5510258 k;Rui 1415 1422 W4287754183.pdf 3 16 math 0.46826816 ¶ 1422 1423 W4287754183.pdf 3 17 text 0.51339656 kgfori2f1;2g; 1423 1437 W4287754183.pdf 3 18 math 0.51609856 k2f 1437 1440 W4287754183.pdf 3 19 text 0.4818504 1;2;3 1440 1445 W4287754183.pdf 3 20 math 0.50620794 g 1445 1446 W4287754183.pdf 3 21 text 0.6447391 that satisfy 1446 1458 W4287754183.pdf 3 22 math 0.8266755 "¶ R13X j=13X k=1q1 jq2 kR1( j; k); (8) R23X j=13X k=1q1 jq2 kR2( j; k); (9) where" 1458 1564 W4287754183.pdf 3 23 text 0.56053466 the total achievable rates are 1564 1595 W4287754183.pdf 3 24 math 0.47486708 bounded 1595 1603 W4287754183.pdf 3 25 text 0.4930433 by 1603 1606 W4287754183.pdf 3 26 math 0.6607791 ¶ Ri( j; k)ri(j;k); 1606 1627 W4287754183.pdf 3 27 text 0.6762697 "(10) and the constants fri(j;k)gare specified in Appendix A." 1627 1689 W4287754183.pdf 3 28 separator 0.9968705 ¶ 1689 1691 W4287754183.pdf 3 29 title 0.9935 B. Gap to Sum-rate Capacity 1691 1719 W4287754183.pdf 3 30 separator 0.99620557 ¶ 1719 1721 W4287754183.pdf 3 31 text 0.99899423 "In this subsection, we demonstrate that the proposed adap- tive layering and successive decoding schemes, achieve an average sum-rate that for fixed channel gains lies within a constant gap of the sum-rate capacity of the two-user Gaussian interference channel with fullCSIT in the high SNR regime." 1721 2027 W4287754183.pdf 3 32 separator 0.90278196 ¶ 2027 2029 W4287754183.pdf 3 33 text 0.99514556 "For the convenience in notations and analysis, we focus on the symmetric setting, i.e., h2 ij=h2 ji=h2, and assume symmetric average power constraint P1=P2=Pas well as symmetric probability distribution, i.e., q1 k=q2 k=qk. The results can be readily generalized to the non-symmetric setting as well." 2029 2346 W4287754183.pdf 3 34 separator 0.9607589 ¶ 2346 2348 W4287754183.pdf 3 35 text 0.9989525 "In the symmetric case, h22f 1; 2; 3g, the interference channel specified by (5) randomly reduces to either a weak interference channel if h2= 1, or to a strong interference channel ifh2= 2orh2= 3.In order to quantify the desired average rate gap, we analyze the gap in the weak and strong interference regimes separately, where the average of which provides the average rate gap." 2348 2737 W4287754183.pdf 3 36 separator 0.98359275 ¶ 2737 2739 W4287754183.pdf 3 37 text 0.99934304 "Weak interference: In this setting, in order to quantify the gap, we first quantify the gap between our average sum-rate and that of HK. Subsequently, by leveraging the known results on the gap between the sum-rate of HK and the sum-rate capacity, we delineate an upper bound on the average sum-rate gap of interest. In particular, we consider the simple scheme of [3] in which the effective power of some messages is normalized to 1 at each receiver. This simple HK scheme is known to achieve a sum-rate within 2-bits from the sum-rate capacity." 2739 3304 W4287754183.pdf 3 38 separator 0.9142208 ¶ 3304 3306 W4287754183.pdf 3 39 text 0.99943584 "We remark that in the case of weak interference, the achievable sum-rate of the HK-scheme in [3], depending on the channel parameters, is either bounded by the capacity of the multiple access channel formed at each receiver or by the rate constraint of decoding the common message at the unintended receiver. These two different regimes are identified by the relation between the power constraintPand the channel gains k." 3306 3742 W4287754183.pdf 3 40 separator 0.9729346 ¶ 3742 3744 W4287754183.pdf 3 41 text 0.9991439 "Strong interference: For the case of strong interference channel, the sum-rate capacity with full CSIT is known, which can be found by evaluating the sum-rate of the intersection of two capacity regions corresponding to two multiple access channels formed by the transmitters and each of the two receivers [5]. We leverage this to quantify the sum-rate gap of interest." 3744 4127 W4287754183.pdf 3 42 separator 0.806467 ¶ 4127 4129 W4287754183.pdf 3 43 text 0.9987817 "Based on these, we delineate the gap between our average sum-rate and the sum-rate capacity in the next theorem." 4129 4244 W4287754183.pdf 3 44 separator 0.9916587 ¶ 4244 4246 W4287754183.pdf 3 45 text 0.8354112 "Theorem 2. In the asymptote of large values of P, the average sum-rate achievable by the proposed broadcast approach lies within a constant gap from the average sum-rate capacity of the symmetric Gaussian interference channel with full CSIT." 4246 4494 W4287754183.pdf 3 46 separator 0.9737177 ¶ 4494 4496 W4287754183.pdf 3 47 text 0.9636473 The gap in the sum-rate is characterized as follows: 4496 4549 W4287754183.pdf 3 48 separator 0.9598378 ¶ 4549 4551 W4287754183.pdf 3 49 math 0.8425403 1 4551 4555 W4287754183.pdf 3 50 separator 0.49642858 ¶ 4555 4557 W4287754183.pdf 3 51 math 0.9303785 2log22q2(2 + 3)1 4557 4575 W4287754183.pdf 3 0 paratext 0.98671025 Page 10/201 0 11 W4310725529.pdf 9 0 paratext 0.9317691 128 0 3 W2326597385.pdf 2 1 text 0.9992024 "Для образцов таких размеров из Ст3 разрушающая нагрузка при bs;400 МПа составляет величину порядка 20 тонн . Поскольку разрывных машин с жесткой системой нагружения и та- кими максимальными усилиями в распоряжении автора не было , испытания проводились на разрывной машине Р – 50 с мягкой системой нагружения . Это потребовало изменить схему эксперимента и разработать соответствующую методику проведения испытаний , позволяющую осуществлять контроль по перемещениям и поддерживать устойчивое деформирование образ - цов при локализации деформаций по жесткопластической схеме согласно (1) вплоть до исчер - пания материалом в рабочей части образцов способности деформироваться . Для этого в схему эксперимента был добавлен упругий элемент , представляющий собой составную балку , лежа - щую на двух опорах и набранную из закаленных пластин 30ХГСНА толщиной от 1 до 5 мм." 3 965 W2326597385.pdf 2 2 separator 0.90125644 ¶ 966 968 W2326597385.pdf 2 3 text 0.99916726 "Это позволило регулировать жесткость упругого элемента как с помощью изменения расстоя - ния между опорами , так и подбором количества пластинок ." 968 1127 W2326597385.pdf 2 4 separator 0.9902718 ¶ 1128 1130 W2326597385.pdf 2 5 text 0.7428119 Схема эксперимента 1130 1150 W2326597385.pdf 2 6 caption 0.5124754 приве 1151 1157 W2326597385.pdf 2 7 text 0.6544752 дена на рис.2. Здесь 1- фундамент разрывной машины 1157 1212 W2326597385.pdf 2 8 caption 0.5467009 , 2 1212 1215 W2326597385.pdf 2 9 text 0.66622484 "- ниж- ний" 1215 1228 W2326597385.pdf 2 10 caption 0.81615895 "захват , 3 – образец , 4 – датчик перемещений краев рабочей части образца , 5 – верхний за- хват, 6 – опоры упругого элемента , 7 – упругий элемент (составная балка ), 8 – средняя опора , 9 – верхний силовой пояс разрывной машины , 10 – рабочий цилиндр , 11 – верхняя силовая бал- ка разрывной машины , 12 – датчик прогибов упругого элемента . Стрелкой показано направле - ние растяжения " 1228 1651 W2326597385.pdf 2 11 text 0.59846747 . 1651 1652 W2326597385.pdf 2 12 separator 0.9946857 ¶ 1653 1655 W2326597385.pdf 2 13 text 0.77584386 Испытания проводились в следующем порядке . 1655 1702 W2326597385.pdf 2 14 separator 0.91317666 ¶ 1703 1705 W2326597385.pdf 2 15 text 0.9994834 "Вначале снималась диаграмма зависимости усилия от перемещений (Р - u) для упругого элемента без образ - ца. Она приведена на рис. 3. Видно , что эта зависи - мость имеет нелинейный участок до перемещения , равного 0,6 мм. Далее начинается близкий к линейно - му участок , на котором отмечены точки , соответст - вующие определенным значениям прогиба упругой балки , снимаемые с датчика 12. Поэтому при проведе - нии испытаний образцов с помощью регулируемой средней опоры 8 осуществлялся предварительный на- тяг упругого элемента на эту величину , после чего датчики 4 и 12 выставлялись на ноль ." 1705 2369 W2326597385.pdf 2 16 separator 0.9788346 ¶ 2370 2372 W2326597385.pdf 2 17 text 0.9990661 "При испытании образцы с помощью регулятора разрывной машины нагружались усилиями , соответст - вующими следующим значениям расхождения берегов рабочей части , определяемым по датчику 4: 0,1 мм, 0,2 мм и далее с шагом 0,1 мм. Этим же датчиком фик- сировалось предельное значение этого расхождения в момент разрушения . Одновременно с датчика 12 сни- мались величины прогиба упругого элемента , соответ - ствующие этому ряду значений расхождения рабочей части образца ." 2372 2901 W2326597385.pdf 2 18 separator 0.9810293 ¶ 2902 2904 W2326597385.pdf 2 19 text 0.9967478 "Далее для получения диаграммы усилие – смещение для рабочей части образца на графике суммарной диаграммы , полученной на записывающем устройстве разрывной машины , строи - лась скорректированная (учитывающая предварительный натяг ) тарированная (см. рис. 3) диа- грамма упругого элемента , и графически вычиталась из суммарной диаграммы Р - u. На рис. 4 " 2904 3291 W2326597385.pdf 2 20 separator 0.53734004 ¶ 3291 3292 W2326597385.pdf 2 21 text 0.9851294 в качестве примера показаны суммарная (кривая 1) и результирующая (кривая 2) диаграммы . 3292 3388 W2326597385.pdf 2 22 separator 0.97291416 ¶ 3389 3391 W2326597385.pdf 2 23 text 0.99873936 "Эти кривые построены в координатах усилие – перемещения краев рабочей части . Момент раз- рушения образца показан звездочкой . Видно , что спадающая ветвь для материала СтЗ при ло- кализации пластических деформаций по схеме Оната и Прагера имеет характер , близкий к линейному ." 3391 3699 W2326597385.pdf 2 24 separator 0.97476757 ¶ 3701 3703 W2326597385.pdf 2 25 text 0.99942297 "После разрушения образцов с помощью регулятора разрывной машины производилось плавное снижение нагрузки , при этом кривая разгрузки после переходного периода выходила на диаграмму упругого элемента (кривая 3 на рис.4). Это доказывает , что диссипацией энергии в упругом элементе из-за наличия трения между упругими пластинками можно пренебречь ." 3703 4089 W2326597385.pdf 2 26 separator 0.9236759 ¶ 4090 4092 W2326597385.pdf 2 27 text 0.9994097 "Таким образом , жесткопластическое решение Оната и Прагера при шейкообразовании получи - ло экспериментальное подтверждение ." 4092 4227 W2326597385.pdf 2 28 separator 0.95808387 ¶ 4228 4230 W2326597385.pdf 2 29 text 0.9986958 "По предложенной методике было испытано восемь образцов . Основные результаты прове - денных экспериментов представлены в таблице ." 4230 4373 W2326597385.pdf 2 30 separator 0.9956187 ¶ 4374 4376 W2326597385.pdf 2 31 table 0.98635095 "12 11 10 9 8 7 6 5 4 3 2 1 регулируемый зазор (натяг )" 4377 4467 W2326597385.pdf 2 32 separator 0.95789427 ¶ 4468 4470 W2326597385.pdf 2 33 caption 0.97112226 Р и с. 2. Схема эксперимента 4470 4500 W2326597385.pdf 2 0 paratext 0.9861595 fmicb-12-689246 December 1, 2021 Time: 13:43 # 14 0 49 W4200099905.pdf 13 1 separator 0.9641223 ¶ 49 51 W4200099905.pdf 13 2 title 0.98973435 Kant and Pancholi Tyrosine Phosphorylation in Streptococcus pyogenes 51 120 W4200099905.pdf 13 3 separator 0.9896626 ¶ 120 122 W4200099905.pdf 13 4 caption 0.9872072 "FIGURE 6 | In vivo phosphorylation of WalR and CovR. (A,B) Mass-spectrometry analysis of the in vivo phosphorylated WalR (A)and CovR (B).In vivo phosphorylation of His-WalR and His-CovR was achieved by purifying Ni-NTA affinity column-purified His-WalR and His-CovR from the whole-cell extract of the M1T11SP-PTP:: His-walR or M1T11SP-PTP:: His-covR strain constructed by complementing M1T1 1PTP mutant with the His-walR orHis-covR gene using pDC123 plasmid. Phosphorylated residues are shown in red fonts The N" 122 638 W4200099905.pdf 13 5 text 0.77426076 "-terminal sequence of CovR shown in blue fonts (the N-terminal half) is a regulator-CovRR, and the sequence in the bracket are the trypsin fragments detected by Mass-spectromtery. (see also Supplementary Table 6 for the detailed mass spectrometry analysis" 638 897 W4200099905.pdf 13 6 caption 0.95496607 "). (C).Comparison with in vitro andin vivo phosphorylated residues of WalR and CovR. Residues in bold fonts depict their presence both in vivo andin vitro under the provided conditions. (D)Electrophoretic Mobility Shift Assay (EMSA), showing the binding of purified non-phosphorylated and phosphorylated CovR with the promoter covR (PcovR ) at different concentrations as indicated." 897 1282 W4200099905.pdf 13 7 text 0.8513708 "Free and differentially migrated bound forms of the P covR DNA probe (266 bp) bands were resolved on 6% native gel and visualized using SYBRGreen stain as described in the “Materials and Methods” section (see Supplementary Figure 4 )." 1282 1519 W4200099905.pdf 13 8 caption 0.5699458 Arrow 1519 1525 W4200099905.pdf 13 9 text 0.6184383 s 1525 1526 W4200099905.pdf 13 10 caption 0.5004588 ¶ 1526 1528 W4200099905.pdf 13 11 text 0.58861697 indicate the positions of differentially migrated 1528 1578 W4200099905.pdf 13 12 caption 0.5955122 bands of the bound DNA probe with and without 1578 1624 W4200099905.pdf 13 13 text 0.5460339 CovR and SP-Ty 1624 1639 W4200099905.pdf 13 14 caption 0.6523765 K-phosphorylated CovR-P . The image is 1639 1677 W4200099905.pdf 13 15 text 0.57253134 the 1677 1682 W4200099905.pdf 13 16 caption 0.5183021 ¶ 1682 1683 W4200099905.pdf 13 17 text 0.6324566 PhotoShop software-converted revert image of the 1683 1732 W4200099905.pdf 13 18 caption 0.5184642 original 1732 1741 W4200099905.pdf 13 19 text 0.61656344 image of the SYBRgreen-stained 1741 1773 W4200099905.pdf 13 20 caption 0.50555843 native gel 1773 1783 W4200099905.pdf 13 21 text 0.6855499 (see Supplementary Figure 5 1783 1812 W4200099905.pdf 13 22 caption 0.5128477 ).( 1812 1815 W4200099905.pdf 13 23 text 0.65072715 "E)Bound and free bands were quantitatively analyzed by spot densitometric analysis using the ImageJ software. Each data point in the line graph shows a ratio of Bound vs. Free arbitrary densitometric units of P covR preincubated with or without different concentrations (0.09–1.35 M) of non-phosphorylated CovR and SP-TyK-phosphorylated CovR-P ." 1815 2167 W4200099905.pdf 13 24 separator 0.9868612 ¶ 2167 2169 W4200099905.pdf 13 25 text 0.9940067 "the remaining observation period. The group of mutant strain-infected mice showed significantly low mortality (20%, pD0.039). At a higher infecting dose, all mice of the M1T1-WT and M1T11TyK:: tykgroups died by 5–7 days, indicating that the complementation with wild-type sp-tyk restored virulence trait. Even at the higher dose, the mutant strain caused significantly lower mortality (30% mortality, pD0.0016), as was observed in the mice challenged with the lower infecting dose of GAS. Together these results showed that SP-TyK played a crucial role in the maintenance of the GAS virulence." 2169 2779 W4200099905.pdf 13 26 separator 0.9945977 ¶ 2779 2781 W4200099905.pdf 13 27 title 0.97336245 "The Absence of Streptococcus pyogenes -Tyrosine Kinase Adversely Impacts Group A Streptococcus Ability to Adhere to and Invade Host Cells and Form Biofilms" 2781 2944 W4200099905.pdf 13 28 separator 0.9905132 ¶ 2944 2946 W4200099905.pdf 13 29 text 0.9996753 "The results described above showing in vitro ability of the mutant to induce inflammatory responses and at the same time in vivo mutant’s inability to cause GAS disease, indicated that additional mechanisms were involved in the attenuation process. In the conventional tissue-culture plate-based bacterial adherence and gentamycin-protection-based invasion assays revealed significantly fewer numbers of M1T1 1TyK adhered toA549 cells ( p<0.0001) ( Figure 8A ). The complemented strain significantly recovered adherence capacity, yet it did not reach the wild-type control strains level. The adherence of all control strains was comparable and with no significant differences among them. Subsequently, parallel invasion assays also revealed the compromised ability of the mutant strain to invade the host cells (pD0.001) ( Figure 8B ). The complemented strain recovered its capacity to invade the A549 cell lines similar to control wild-type and other control GAS strains. In the control wells without cells, the input of the bacterial count at the end of 3 h of incubation remained essentially the same as at starting t 0-time point. These results thus indicated that the innate capacity of the mutant to adhere and invade the host cells was severely compromised, which was not influenced by the growth defect or the number of bacteria ( Figures 8A,B )." 2946 4335 W4200099905.pdf 13 30 separator 0.9605666 ¶ 4335 4337 W4200099905.pdf 13 31 text 0.9991373 "The increased expression of SpeB and downregulated PTS and other transport system-related genes in M1T1 1TyK mutant ( Table 2 ) indicated that S. pyogenes biofilm formation might adversely affect as reported recently in a time and stage-dependent proteomic and transcriptomic analyses of S. pyogenes biofilm formation revealing the importance of several differentially expressed genes encoding for carbohydrate, lipid, and transport metabolism, cell division, chromosome partitioning, and cell wall biogenesis (Freiberg et al., 2016)." 4337 4884 W4200099905.pdf 13 32 separator 0.96593827 ¶ 4884 4886 W4200099905.pdf 13 33 paratext 0.9822993 Frontiers in Microbiology | www.frontiersin.org 14 December 2021 | Volume 12 | Article 689246 4886 4980 W4200099905.pdf 13 0 title 0.7294485 "Current Evidence on Computer- Aided Diagnosis of Celiac Disease: Systematic Review" 0 86 W3017237296.pdf 0 1 separator 0.9919765 ¶ 86 88 W3017237296.pdf 0 2 contact 0.906732 "Adriana Molder1,2, Daniel Vasile Balaban1,3*, Mariana Jinga1,3 and Cristian-Constantin Molder2" 88 185 W3017237296.pdf 0 3 separator 0.9724649 ¶ 185 187 W3017237296.pdf 0 4 contact 0.98836154 "1Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,2Center of Excellence in Robotics and Autonomous Systems, Military Technical Academy Ferdinand I, Bucharest, Romania,3Gastroenterology Department, Dr. Carol Davila Central Military Emergency University Hospital, Bucharest, Romania" 187 492 W3017237296.pdf 0 5 separator 0.99203706 ¶ 492 494 W3017237296.pdf 0 6 text 0.9991623 "Celiac disease (CD) is a chronic autoimmune disease that occurs in genetically predisposed individuals in whom the ingestion of gluten leads to damage of the smallbowel. It is estimated to affect 1 in 100 people worldwide, but is severely underdiagnosed." 494 751 W3017237296.pdf 0 7 separator 0.91296285 ¶ 751 753 W3017237296.pdf 0 8 text 0.9992752 "Currently available guidelines require CD-speci fic serology and atrophic histology in duodenal biopsy samples for the diagnosis of adult CD. In pediatric CD, but in recentyears in adults also, nonbioptic diagnostic strategies have become increasingly popular. Inthis setting, in order to increase the diagnostic rate of this pathology, endoscopy itself hasbeen thought of as a case finding strategy by use of digital image processing techniques." 753 1200 W3017237296.pdf 0 9 separator 0.97707474 ¶ 1200 1202 W3017237296.pdf 0 10 text 0.99957544 "Research focused on computer aided decision support used as database video capsule,endoscopy and even biopsy duodenal images. Early automated methods for diagnosis ofceliac disease used feature extraction methods like spatial domain features, transformdomain features, scale-invariant features and spatio-temporal features. Recent arti ficial intelligence (AI) techniques using deep learning (DL) methods such as convolutional neuralnetwork (CNN), support vector machines (SVM) or Bayesian inference have emerged as abreakthrough computer technology which can be used for computer aided diagnosis ofceliac disease. In the current review we summarize methods used in clinical studies forclassi fication of CD from feature extraction methods to AI techniques." 1202 1960 W3017237296.pdf 0 11 separator 0.98855615 ¶ 1960 1962 W3017237296.pdf 0 12 text 0.5056473 Keywords: celiac disease, computer aided diagnosis, arti ficial intelligence, endoscopy, 1962 2050 W3017237296.pdf 0 13 paratext 0.4357656 feature 2050 2058 W3017237296.pdf 0 14 text 0.42648286 2058 2059 W3017237296.pdf 0 15 paratext 0.5278295 extraction 2059 2069 W3017237296.pdf 0 16 separator 0.9969385 ¶ 2069 2071 W3017237296.pdf 0 17 title 0.98048466 INTRODUCTION 2071 2084 W3017237296.pdf 0 18 separator 0.9926785 ¶ 2084 2086 W3017237296.pdf 0 19 text 0.9987419 "Celiac disease (CD) is a systemic autoimmune disease driven by gluten ingestion in genetically susceptible individuals. At some point during their lifetime, some of the DQ2/DQ8 positiveindividuals become gluten intolerant and develop an autoimmune reaction in response to dietarygluten, leading to small bowel injury consisting in villous atrophy (VA) and crypt hyperplasia.Although it is one of the most common chronic digestive disorders, with prevalence rate of 1%worldwide ( Ludvigsson et al., 2016 ), CD is severely underdiagnosed. This is due to the frequently mislabeling patients with irritable bowel syndrome, lack of awareness among medical professionals about the extra-intestinal presentations of the disease ( Jinga et al., 2018 ) and missed opportunities to screen for CD such as first-grade relatives, high-risk groups and not least scoping the upper " 2086 2960 W3017237296.pdf 0 20 separator 0.6562642 ¶ 2960 2961 W3017237296.pdf 0 21 paratext 0.977615 Frontiers in Pharmacology | www.frontiersin.org April 2020 | Volume 11 | Article 341 2961 3046 W3017237296.pdf 0 22 contact 0.98731226 "1Edited by: Jean-Marie Boeynaems, Université libre de Bruxelles, Belgium Reviewed by: Michael Thiede, IUBH University of Applied Sciences, Germany Kurt Neumann, Independent Researcher, Kerékteleki, Hungary *Correspondence: Daniel Vasile Balaban vasile.balaban@umfcd.ro" 3046 3339 W3017237296.pdf 0 23 separator 0.9266585 ¶ 3339 3341 W3017237296.pdf 0 24 paratext 0.85139155 "Specialty section: This article was submitted to Pharmaceutical Medicine and Outcomes Research, a section of the journal Frontiers in Pharmacology Received: 01 December 2019 Accepted: 09 March 2020 Published: 16 April 2020" 3341 3580 W3017237296.pdf 0 25 separator 0.919031 ¶ 3580 3582 W3017237296.pdf 0 26 paratext 0.97549075 Citation: 3582 3592 W3017237296.pdf 0 27 separator 0.47619346 3592 3593 W3017237296.pdf 0 28 paratext 0.89234823 "¶ Molder A, Balaban DV, Jinga M and Molder C-C (2020) Current Evidence on Computer-Aided Diagnosis of Celiac Disease: Systematic Review. Front. Pharmacol. 11:341. doi: 10.3389/fphar.2020.00341SYSTEMATIC REVIEW published: 16 April 2020 doi: 10.3389/fphar.2020.00341" 3593 3871 W3017237296.pdf 0 0 paratext 0.9883054 International Journal of Engineering & Technology 497 0 55 W2942087152.pdf 2 1 separator 0.8412837 ¶ 56 58 W2942087152.pdf 2 2 text 0.66465044 60 61 W2942087152.pdf 2 3 separator 0.8775537 ¶ 61 62 W2942087152.pdf 2 4 text 0.9983517 "that correspond to the light intensity is necessary. This can be done by passing the light through a sample without reagent known which is th e blank sample. The circuit does not give 0V output reading when no light pass through. Due to this error, correction needs to be made by eliminating voltage reading at zero light ( from all the sample readings as in (2)." 62 445 W2942087152.pdf 2 5 separator 0.7709043 ¶ ¶ 447 453 W2942087152.pdf 2 6 text 0.73098224 (2) 479 483 W2942087152.pdf 2 7 separator 0.5490209 484 485 W2942087152.pdf 2 8 text 0.94460857 "¶ Based on equation (1) and (2), the absorbance equation can be simplified as in (3)." 485 577 W2942087152.pdf 2 9 separator 0.5687929 ¶ ¶ 579 585 W2942087152.pdf 2 10 text 0.7646719 (3) 596 600 W2942087152.pdf 2 11 separator 0.99692833 ¶ 601 603 W2942087152.pdf 2 12 title 0.9934807 2.4. Coefficient of Determination 603 637 W2942087152.pdf 2 13 separator 0.9960624 ¶ 639 641 W2942087152.pdf 2 14 text 0.9997011 "Coefficient of determination, R2 is a number that can show how good a series of data used in an experiment fits to a statistical model [15]. Ranging from 0 to 1, the most good relationship is when the value of R2 nearest to 1. In statistics, this is how they measure the success fulness level of an outcome to a model. In this experiment, the coefficient of determination is used to measure the relationship value between the light absorbance and the solution concentration. R2 can be measured through the equ ation in (4)." 641 1188 W2942087152.pdf 2 15 separator 0.80116785 ¶ ¶ 1190 1196 W2942087152.pdf 2 16 text 0.8747166 (4) 1220 1224 W2942087152.pdf 2 17 separator 0.7199494 ¶ 1225 1230 W2942087152.pdf 2 18 text 0.9847109 "¶ Where refer to the number of solution, and refer to the light absorbance and the concentration of solution respectively. Lastly, refer to the mean of light absorbance an d mean of the concentration of the solution." 1230 1476 W2942087152.pdf 2 19 separator 0.9967755 ¶ 1478 1480 W2942087152.pdf 2 20 title 0.99358636 2.4. Linear Regression 1480 1503 W2942087152.pdf 2 21 separator 0.9962021 ¶ 1505 1507 W2942087152.pdf 2 22 text 0.9996308 "From Beer Lambert’s law [4], linear regression method is always used to determine unknown concentration of a solution. This is by using the light absorbance of the solution. It is used to model the relationship between y, the concentration of the sol ution to X, the light absorbance (5). While a is a constant value when X is 0 and b is slope." 1507 1869 W2942087152.pdf 2 23 separator 0.92694837 ¶ ¶ 1871 1877 W2942087152.pdf 2 24 text 0.9699828 (5) 1889 1893 W2942087152.pdf 2 25 separator 0.99690676 ¶ 1894 1896 W2942087152.pdf 2 26 title 0.9919007 3. Experimental Result 1896 1919 W2942087152.pdf 2 27 separator 0.9949118 ¶ 1921 1923 W2942087152.pdf 2 28 title 0.9920168 3.1. Maximum Absorbance Wavelength 1923 1958 W2942087152.pdf 2 29 separator 0.99513936 ¶ ¶ 1960 1966 W2942087152.pdf 2 30 caption 0.9491679 Fig. 4: Absorbance spectrum graph 1966 2000 W2942087152.pdf 2 31 separator 0.9882 ¶ 2002 2004 W2942087152.pdf 2 32 text 0.9995292 "Fig. 4 shows the absorbance spectrum graph of the samples that have different iron concentrations ranging from 0 μg/L to 4000 μg/L. the blank sample is labelled as woFRZ. Y-axis of the graph refers to absorbance and the x -axis refers to the wavelength. The graph have the bell -shaped curve denotes that the absorbance i n- creases when the wavelength increases (400nm to 562nm). A c- cordingly, as the wavelength goes from 562nm to 700nm, the absorbance decreases. The graph proves that the peak of the wav e- length is at 562nm. It also concludes that as the concentration of the iron increases, the light absorbance of the solution increases." 2004 2679 W2942087152.pdf 2 33 separator 0.9973004 ¶ 2681 2683 W2942087152.pdf 2 34 title 0.9926731 3.2. Linear Regression Graph 2683 2712 W2942087152.pdf 2 35 separator 0.99547595 ¶ ¶ 2714 2720 W2942087152.pdf 2 36 caption 0.9933956 "Fig. 5: Calibration curve comparison between spectrophotometer and the body iron reader." 2720 2812 W2942087152.pdf 2 37 separator 0.9717308 ¶ ¶ 2814 2820 W2942087152.pdf 2 38 text 0.9996933 "In our experim ent, the result obtained is compared with the co m- mercially available spectrophotometer machine to know the eff i- ciency. Fig. 5 shows the plots of calibration curve for the spectr o- photometer and the body iron reader. Both of the instruments fu l- filled the Bee r Lambert ’s law as they can produce a straight line." 2820 3166 W2942087152.pdf 2 39 separator 0.97525734 ¶ 3168 3170 W2942087152.pdf 2 40 text 0.99926263 "The straight line is plotted between the concentrations of the sol u- tion to the absorbance and calculated using the linear regression relationship. R2 is the coefficient of the determ ination. The straight line in blue indicates the calibration curve for the spectrophotom e- ter that have the gradient of 0.9999. While the body iron reader have the gradient of 0.9986 which is shown in the red line. The values show that the gradient of the body iron reader is ve ry close to the gradient of commercially available spectrophotometer. As the maximum value for R2 is 1, the pe rcentage error between them is only 0.13%. This proves that the reader is suitable to be used for analytical chemistry." 3170 3897 W2942087152.pdf 2 0 text 0.9995616 "inflammation; (ii) healthy treated tooth (HTT) group included teeth in which the pre-existing endodontic filling material was exposed to oral cavity with no sign of periapical lesion; (iii) irreversible pulpitis (IP) diagnosed by sharp spontaneous pain and tenderness to percussion or pain exacerbated by lying down or cold test ( Levin et al., 2009 ); (iv) pulp necrosis (N) group belonged to untreated teeth, negative to cold test, with and without apical periodontitis; post-treatment apical periodontitis (PTAP)." 0 528 W4362671203.pdf 2 1 separator 0.99638194 ¶ 528 530 W4362671203.pdf 2 2 title 0.99059963 Sampling and clinical procedures 530 563 W4362671203.pdf 2 3 separator 0.99470234 ¶ 563 565 W4362671203.pdf 2 4 text 0.9997287 "Root canal and saliva samples were collected as previously described ( Sedgley et al., 2006a ). Before isolation with the rubber dam, saliva samples from the floor of the mouth, dorsum of the tongue and the crown of the affected tooth were collected for each patient using three sterile ISO size 40 paper points (Dentsply- Maillefer, Ballaigues, Switzerland). The paper points were resuspended in 100 ml of PBS/10% glycerol and stored at -70°C until analysis. Plaque around the affected tooth was removed using scalers and the surfaces were brushed with pumice. Teeth wereisolated with a rubber dam and disinfected with 30% hydrogen peroxide and 5.25% sodium hypochlorite (NaOCl), which is inactivated by sodium thiosulphate 5%. As a sterility control, three sterile paper points (Size 40) were rubbed on the crown of the tooth and on the surrounding areas. After access preparation, root canal patency was achieved with minimal instrumentation and without using hypochlorite irrigant. In case of retreatment, coronal gutta percha was removed by sterile Gates Glidden drills size 2 & 3 (Dentsply-Maillefer, Ballaigues, Switzerland), while the middle and apical gutta percha were removed with endodontic files without a chemical solvent. Irrigation was performed with sterile saline to remove any residual material before the collection of the intracanal sample. Once the working length was established, the pre-treatment sample was collected using ISO size 10 K- file (Dentsply-Maillefer, Ballaigues, Switzerland). An additional pretreatment sampling was performed by introducing two sterile paper points (ISO size 15) into the full working length kept for at least 60 seconds. The sample was then transferred to PBS/10% glycerol solution. When the canal was dry, a sterile paper point moistened with sterile saline was used to acquire the sample. In multi-rooted teeth, a single root canal was chosen, based on the presence of periapical radiolucency and/ or exudation." 565 2591 W4362671203.pdf 2 5 separator 0.9969437 ¶ 2591 2593 W4362671203.pdf 2 6 title 0.9922849 Laboratory assessment 2593 2615 W4362671203.pdf 2 7 separator 0.9922856 ¶ 2615 2617 W4362671203.pdf 2 8 title 0.9898054 Isolation and identi fication of Enterococci 2617 2661 W4362671203.pdf 2 9 separator 0.9875804 ¶ 2661 2663 W4362671203.pdf 2 10 text 0.9990423 "Tenml of PBS/10% glycerol from each sample were plated on Brain Heart Infusion (BHI) agar containing 5% horse blood. The plates were incubated in 5% CO 2at 37°C for 48 hours and monitored daily for the presence of microbial growth. Putative enterococcal colonies were isolated on BHI agar/blood and identi fied with a latex agglutination test (OxoidTMStreptococcal Grouping Kit, Thermo Fisher, Hampshire, United Kingdom). Group D colonies were then identi fied on a MALDI Biotyper (Bruker Daltonics, Bremen, Germany) and by ribosomal RNAoperon sequencing ( Cusco ́et al., 2018 ). Colonies identi fied as E. faecalis were frozen at -70°C in BHI/10% glycerol." 2663 3335 W4362671203.pdf 2 11 separator 0.9963269 ¶ 3335 3337 W4362671203.pdf 2 12 title 0.9895814 High molecular weight DNA extraction 3337 3374 W4362671203.pdf 2 13 separator 0.9878856 ¶ 3374 3376 W4362671203.pdf 2 14 text 0.9996739 "E. faecalis strains were streak plated on BHI agar/blood, incubated overnight at 37°C and checked for purity. About ten single colonies were inoculated in BHI broth and the starter cultures of exponentially growing bacteria (OD 590of 0.3-0.4) were frozen at -70°C with 10% glycerol. Bacteria were inoculated 1:50 (vol:vol) from starter cultures in 10 ml of BHI broth and incubated at 37° C until an OD 590of 1.0 was reached. Samples were then centrifuged at 6600 x gfor 5 minutes. Bacterial pellets were washed with 10 ml of sterile 1X TE buffer (Tris 10 mM-EDTA 1 mM) and resuspended in 7.5 ml of Raf finose buffer (50 mM Tris pH 8, 5 mM EDTA, 20% Raffinose). DNA extraction was carried out as described previously (Pinzauti et al., 2022 ). The DNA pellet was resuspended in 100 mlo f saline. Genomic DNA was quanti fied using a Qubit 2.0 fluorometer (Invitrogen, Whaltan, Massachusetts, USA) and a NanoPhotometer device (Implen, Westlake Village, USA) before molecular analysisand whole genome sequencing." 3376 4408 W4362671203.pdf 2 15 separator 0.9969504 ¶ 4408 4410 W4362671203.pdf 2 16 title 0.992793 Sequencing and bioinformatic analysis 4410 4448 W4362671203.pdf 2 17 separator 0.99296653 ¶ 4448 4450 W4362671203.pdf 2 18 text 0.9997094 "Whole genome sequencing (WGS) was performed employing Oxford Nanopore technology. Following manufacturers ’ instruction, the sequencing library was prepared using a ligation sequencing kit (SQK-LSK108) and barcode expansion kits (EXP- NBD104/114) for sample multiplexing. The sequencing run was performed on the GridION x5 platform (Oxford Nanopore Technologies). Nanopore reads were filtered using the tool Filtlong (v. 0.2.0) ( https://github.com/rrwick/Filtlong ) removing reads shorter than 1,000 bases ( –min_length 1000) and getting rid of the 5% worst (low quality) reads ( –keep_percentage 95)." 4450 5070 W4362671203.pdf 2 19 separator 0.8852756 ¶ 5070 5072 W4362671203.pdf 2 20 text 0.9996529 "Samples were also sequenced with Illumina technology at MicrobesNG (Birmingham, UK) ( https://microbesng.com/ ) which performed library preparation and sequencing of paired end 250 bp reads on a HiSeq2500. Raw Illumina reads were quality checked at MicrobesNG: reads were trimmed using Trimmomatic (v. 0.30)(Bolger et al., 2014 ) and analyzed with FastQC (v. 0.11.5) ( http:// www.bioinformatics.babraham.ac.uk/projects/fastqc )." 5072 5512 W4362671203.pdf 2 21 separator 0.9626539 ¶ 5512 5514 W4362671203.pdf 2 22 text 0.99957824 "High quality complete genomes were de novo assembled using Unicycler (v 0.4.7) ( Wick et al., 2017 ), with both Nanopore and Illumina reads as an input. Phylogenetic relationships among sequenced genomes were explored using PopPUNK (v. 2.4.0) using the ‘fit-model lineage ’parameter for data fitting ( Lees et al., 2019 ). PopPUNK exploits the Jaccard index (J) to establish the similarity between k-mer data sets (oligonucleotide sequences of k length) of two genome sequences (0