entity_group score word start end file page_number 0 contact 0.7866254 EDITED BY 0 9 W4313640121.pdf 0 1 separator 0.74611413 ¶ 9 11 W4313640121.pdf 0 2 contact 0.9899501 "Sami-Ramzi Leyh-Bannurah, Pediatric Urology and Urological Oncology, Germany" 11 92 W4313640121.pdf 0 3 separator 0.86610603 ¶ 92 94 W4313640121.pdf 0 4 contact 0.9774206 "REVIEWED BY Andrey O Morozov, I.M. Sechenov First Moscow State Medical University, RussiaPawel Rachubinski, Pediatric Urology and Urological Oncology, Germany Mykyta Kachanov, University Medical Center Hamburg-Eppendorf,Germany *" 94 340 W4313640121.pdf 0 5 separator 0.62991774 ¶ 340 342 W4313640121.pdf 0 6 contact 0.9944532 "CORRESPONDENCE Qiang Wei weiqiang933@126.com Lu Yang wycle flue@163.com" 342 421 W4313640121.pdf 0 7 separator 0.94414675 ¶ 421 423 W4313640121.pdf 0 8 paratext 0.7183936 "†These authors have contributed equally to this work" 423 478 W4313640121.pdf 0 9 separator 0.9742417 ¶ 478 480 W4313640121.pdf 0 10 title 0.6154175 SPECIALTY SECTION 480 498 W4313640121.pdf 0 11 separator 0.59123665 ¶ 498 500 W4313640121.pdf 0 12 paratext 0.79696655 This article was submitted to GenitourinarySurgery, a section of the journal Frontiers inSurgery 500 597 W4313640121.pdf 0 13 separator 0.650178 ¶ 597 599 W4313640121.pdf 0 14 paratext 0.8300144 "RECEIVED 30 September 2022 ACCEPTED 05 December 2022 PUBLISHED 06 January 2023" 599 682 W4313640121.pdf 0 15 separator 0.99301934 ¶ 682 684 W4313640121.pdf 0 16 title 0.78040886 CITATION 684 693 W4313640121.pdf 0 17 separator 0.98779535 ¶ 693 695 W4313640121.pdf 0 18 bibliography 0.995719 "Zhang C, Tu X, Dai J, Xiong X, Cai D, Yang L, Zhang M, Qiu S, Lin T, Liu Z, Yang L and Wei Q" 695 790 W4313640121.pdf 0 19 separator 0.95964926 ¶ 790 792 W4313640121.pdf 0 20 paratext 0.6755159 "(2023) Ef ficacy and safety of the new biopsy strategy combining 6-core systematic and 3- core MRI-targeted biopsy in the detection ofprostate cancer: Study protocol for a randomized controlled trial." 792 998 W4313640121.pdf 0 21 separator 0.8512613 ¶ 998 1000 W4313640121.pdf 0 22 paratext 0.9326359 "Front. Surg. 9:1058288. doi: 10.3389/fsurg.2022.1058288" 1000 1058 W4313640121.pdf 0 23 separator 0.98071474 ¶ 1058 1060 W4313640121.pdf 0 24 paratext 0.89156157 "COPYRIGHT © 2023" 1060 1079 W4313640121.pdf 0 25 bibliography 0.93583924 "Zhang, Tu, Dai, Xiong, Cai, Yang, Zhang, Qiu, Lin, Liu, Yang and Wei" 1079 1150 W4313640121.pdf 0 26 paratext 0.86774814 ". This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) ." 1150 1266 W4313640121.pdf 0 27 separator 0.9343494 ¶ 1266 1268 W4313640121.pdf 0 28 paratext 0.9374783 "The use, distribution or reproduction in otherforums is permitted, provided the originalauthor(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with acceptedacademic practice. No use, distribution orreproduction is permitted which does not comply with these terms.E" 1268 1608 W4313640121.pdf 0 29 title 0.7691722 "fficacy and safety of the new biopsy strategy combining6-core systematic and 3-coreMRI-targeted biopsy in thedetection of prostate cancer:Study protocol for a randomizedcontrolled trial" 1608 1794 W4313640121.pdf 0 30 separator 0.9956358 ¶ 1794 1796 W4313640121.pdf 0 31 bibliography 0.62170243 Chichen Zhang1†, Xiang Tu1†, Jindong Dai1, Xing 1796 1844 W4313640121.pdf 0 32 contact 0.43702093 yu 1844 1846 W4313640121.pdf 0 33 bibliography 0.6585026 "Xiong1, Diming Cai2, Ling Yang3, Mengni Zhang4, Shi Qiu1, Tianhai Lin1, Zhenhua Liu1, Lu Yang1*and Qiang Wei" 1846 1959 W4313640121.pdf 0 34 contact 0.60570246 1* 1959 1961 W4313640121.pdf 0 35 separator 0.9916941 ¶ 1961 1963 W4313640121.pdf 0 36 contact 0.9871459 "1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China,2Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China, 3Department of Radiology, West China Hospital, Sichuan University, Chengdu, China,4Department of Pathology and Laboratory of Pathology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China" 1963 2385 W4313640121.pdf 0 37 separator 0.9945765 ¶ 2385 2387 W4313640121.pdf 0 38 text 0.99893135 "Background: Recent EAU guideline strongly recommended combined targeted biopsy (TBx) with systematic biopsy (SBx) for biopsy naïve patientswith suspected multiparametric magnetic resonance imaging (mpMRI) lesions; However, the clinical goal is to find out how to determine the optimal SBx and TBx cores for biopsy in order to maximize the detection ofcsPCa and minimize the associated defects. This study aims to assess the efficacy and safety of the new biopsy strategy combining 6-core systematic and 3-core MRI- TBx compared to 12-core systematic and 3-core MRI-TBxstrategy." 2387 2973 W4313640121.pdf 0 39 separator 0.9204451 ¶ 2973 2975 W4313640121.pdf 0 40 text 0.99758357 "Methods: This is a single-center, prospectively randomized controlled clinical trial. 280 men meeting inclusion criteria will be recruited and will be randomlyallocated to either 6-core systematic plus 3-core MRI-TBx group (Group A) or 12-core systematic plus 3-core MRI-TBx group (Group B). The primary outcome compares the detection rate of PCa and clinically signi ficant prostate cancer(csPCa) between group A and group B. The secondary outcomes compare the participant-reported pain score immediate post biopsy using pain measurement scale; proportion of men with post-biopsycomplications and adverse events (Time frame: 7 days post biopsy, 30 days post biopsy); proportion of the men who undergo radical prostatectomy and have cancer upgraded histopathology from the biopsy to the radicalprostatectomy." 2975 3799 W4313640121.pdf 0 41 separator 0.99674416 ¶ 3799 3801 W4313640121.pdf 0 42 title 0.94801134 Abbreviations 3801 3815 W4313640121.pdf 0 43 separator 0.99129903 ¶ 3815 3817 W4313640121.pdf 0 44 text 0.792055 "PCa, Prostate cancer; TRUS, transrectal ultrasound-guided; csPCa, clinically signi ficant prostate cancers; mpMRI, multiparametric magnetic resonance imaging; PI-RADS, prostate imaging-reporting and datasystem; EAU, European Association of Urology; RCT, randomized controlled trial; SD, standard deviation; IQR, interquartile range." 3817 4153 W4313640121.pdf 0 45 paratext 0.46590105 TYPE 4153 4157 W4313640121.pdf 0 46 title 0.54876524 Study 4157 4163 W4313640121.pdf 0 47 paratext 0.6536328 Protocol 4163 4172 W4313640121.pdf 0 48 separator 0.9691847 ¶ 4172 4174 W4313640121.pdf 0 49 paratext 0.9060351 PUBLISHED 06 January 2023| DOI10.3389/fsurg.2022.1058288 4174 4231 W4313640121.pdf 0 50 separator 0.88777876 ¶ 4231 4233 W4313640121.pdf 0 51 paratext 0.9485338 Frontiers in Surgery 01 frontiersin.org 4233 4273 W4313640121.pdf 0 0 paratext 0.9866026 March 2019/ Vol 6/ Issue 03 Print ISSN: 23 49-5499, Online ISSN: 2349-3267 0 134 W3010183709.pdf 5 1 separator 0.6796977 135 136 W3010183709.pdf 5 2 paratext 0.9551998 "¶ Original Research Article Pediatric Review: International Journal of Pediatri c Research Available online at: www.medresearch.in 112|P a g e" 136 420 W3010183709.pdf 5 3 bibliography 0.9974009 "5. 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Journal of Theoretical Biology 251, 606 –615." 7535 7749 W4367297861.pdf 7 79 separator 0.9802412 ¶ 7749 7751 W4367297861.pdf 7 80 bibliography 0.99655575 "Ritchie AM ,Hua X ,Cardillo M ,Yaxley KJ ,Dinnage R and Bromham L (2021) Phylogenetic diversity metrics from molecular phylogenies: Modelling expected degree of error under realistic rate variation. Diversity and Distri- butions 27, 164 –178." 7751 8000 W4367297861.pdf 7 81 separator 0.980382 ¶ 8000 8002 W4367297861.pdf 7 82 bibliography 0.99719465 "Robuchon M ,Pavoine S ,Véron S ,Delli G ,Faith DP ,Mandrici A ,Pellens R , Dubois G and Leroy B (2021) Revisiting species and areas of interest for conserving global mammalian phylogenetic diversity. Nature Communica- tions 12, 3694." 8002 8242 W4367297861.pdf 7 83 separator 0.9708055 ¶ 8242 8244 W4367297861.pdf 7 84 bibliography 0.997569 "Rodrigues ASL and Gaston KJ (2002) Maximising phylogenetic diversity in the selection of networks of conservation areas. Biological Conservation 105, 103–111." 8244 8407 W4367297861.pdf 7 85 separator 0.9831129 ¶ 8407 8409 W4367297861.pdf 7 86 bibliography 0.99726725 "Safi K ,Cianciaruso MV ,Loyola RD ,Brito D ,Armour-Marshall K and Diniz- Filho JAF (2011) Understanding global patterns of mammalian functional and phylogenetic diversity. Philosophical Transactions of the Royal Society B: Biological Sciences 366, 2536 –2544.8 Marcel Cardillo" 8409 8692 W4367297861.pdf 7 87 separator 0.898679 ¶ 8692 8694 W4367297861.pdf 7 88 paratext 0.95295143 https://doi.org/10.1017/ext.2023.8 Published online by Cambridge University Press 8694 8777 W4367297861.pdf 7 0 paratext 0.9698019 57 0 2 W3123131768.pdf 2 1 separator 0.9317101 ¶ 2 4 W3123131768.pdf 2 2 title 0.9825596 The Psychological Implications of Sleep Apnea Sarangi et al. 4 67 W3123131768.pdf 2 3 separator 0.99176985 ¶ 68 70 W3123131768.pdf 2 4 text 0.95262027 "The Southwest Respiratory and Critical Care Chronicles 2020;8(36):55–57potentially worsen the symptoms of OSA by increas - ing upper airway resistance and lowering central res - piratory drive.9" 70 269 W3123131768.pdf 2 5 separator 0.7167959 ¶ 269 271 W3123131768.pdf 2 6 text 0.99910045 "Furthermore, bipolar disorder is characterized by disrupted sleep-wake schedules, daily activities, and appetite, all of which are integrally related to the patient’s circadian system. Mood exacerbations can also be pro - voked by seasonal patterns and alterations in light inten - sity. This may explain concomitant irregular control of sleep, hormone levels, and body temperature, all under circadian control.9 Thus, whether OSA or bipolar disor - der is diagnosed first, each can have a detrimental syn - ergistic effect on the patient if not properly treated." 271 858 W3123131768.pdf 2 7 separator 0.99580705 ¶ 858 860 W3123131768.pdf 2 8 title 0.98867244 conclusIons 860 872 W3123131768.pdf 2 9 separator 0.99596363 ¶ 874 876 W3123131768.pdf 2 10 text 0.99925506 "Obstructive sleep apnea is a multifaceted disorder that manifests itself not only physiologically but also psychologically. It is therefore necessary for a physi - cian to consider a patient’s risk for psychiatric disorders, including major depressive disorder and bipolar disor - der. The link between OSA and major depressive dis - order and bipolar disorder is not well defined, with only a handful of studies on this relationship. Nonetheless, a clear understanding of OSA’s association with psy - chological disorders can introduce novel methods for its diagnosis, prevention, and treatment in patients." 877 1512 W3123131768.pdf 2 11 separator 0.9921356 ¶ 1512 1514 W3123131768.pdf 2 12 bibliography 0.93670166 "Article citation: Sarangi A, Domingo-Johnson EL, Mwangi L, Siddiqui SA, Hsu C. The psychological implications of sleep apnea. The Southwest Respiratory and Critical Care Chronicles 2020;8(36): 55–57" 1514 1723 W3123131768.pdf 2 13 separator 0.9828519 ¶ 1723 1725 W3123131768.pdf 2 14 contact 0.92660993 "From: School of Medicine (ELDJ, LM, AS, CH) and Department of Psychiatry(AS), Texas Tech University Health Sciences Center, Lubbock, Texas" 1725 1871 W3123131768.pdf 2 15 separator 0.92094076 ¶ 1871 1873 W3123131768.pdf 2 16 paratext 0.87673354 "Submitted: 5/14/2020 Accepted: 10/2/2020 Reviewer: " 1873 1931 W3123131768.pdf 2 17 contact 0.5602767 Gilbert Berdine 1931 1946 W3123131768.pdf 2 18 paratext 0.93545705 "MD Conflicts of interest: none This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License." 1946 2084 W3123131768.pdf 2 19 title 0.894249 RefeRences 2084 2094 W3123131768.pdf 2 20 separator 0.9911677 ¶ 2094 2096 W3123131768.pdf 2 21 bibliography 0.99780995 "1. Basyuni S, Barabas M, Quinnell T. An update on mandibular advancement devices for the treatment of obstructive sleep apnoea hypopnoea syndrome. J Thorac Dis 2018;10(Suppl 1): S48–S56. doi:10.21037/jtd.2017.12.18" 2096 2321 W3123131768.pdf 2 22 separator 0.9589042 ¶ 2321 2323 W3123131768.pdf 2 23 bibliography 0.99668765 "2. Bilyukov RG, Nikolov MS, Pencheva VP , et al. Cognitive impairment and affective disorders in patients with obstruc - tive sleep apnea syndrome. Front Psychiatry 2018;9:357. Published 2018 Aug 7. doi:10.3389/fpsyt.2018.00357" 2323 2559 W3123131768.pdf 2 24 separator 0.9745827 ¶ 2560 2562 W3123131768.pdf 2 25 bibliography 0.9940897 "3. Stubbs B, Vancampfort D, Veronese N, et al. The prevalence and predictors of obstructive sleep apnea in major depres - sive disorder, bipolar disorder and schizophrenia: A system - atic review and meta-analysis. J Affective Dis. https://www. sciencedirect.com/science/article/pii/S0165032715311939. Published March 9, 2016. Accessed March 16, 2020." 2562 2926 W3123131768.pdf 2 26 separator 0.97591716 ¶ 2926 2928 W3123131768.pdf 2 27 bibliography 0.9969622 "4. Hodges EL, Marcus CY , Kim JY , et al. Depressive symptom - atology in school-aged children with obstructive sleep apnea syndrome: incidence, demographic factors, and changes fol - lowing a randomized controlled trial of adenotonsillectomy. https://www.ncbi.nlm.nih.gov/pubmed/30212861. Published September 13, 2018. Accessed March 16, 2020." 2928 3287 W3123131768.pdf 2 28 separator 0.97279924 ¶ 3287 3289 W3123131768.pdf 2 29 bibliography 0.99794406 "5. Ahuja S, Chen RK, Kam K, et al. Role of normal sleep and sleep apnea in human memory processing. Nat Sci Sleep 2018; 10:255–269." 3289 3428 W3123131768.pdf 2 30 separator 0.96526057 ¶ 3429 3431 W3123131768.pdf 2 31 bibliography 0.9977517 "6. Olaithe M, Bucks RS, Hillman DR, et al. Cognitive deficits in obstructive sleep apnea: Insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation. Sleep Med Rev 2018;38:39–49." 3431 3667 W3123131768.pdf 2 32 separator 0.97342235 ¶ 3668 3670 W3123131768.pdf 2 33 bibliography 0.9980495 "7. Pan M-L, Hsiao-Mei T, Chien-Chi H, et al. Bidirectional asso - ciation between obstructive sleep apnea and depression. Med - icine 2016;95:e4833." 3670 3823 W3123131768.pdf 2 34 separator 0.9559529 ¶ 3824 3826 W3123131768.pdf 2 35 bibliography 0.99786276 "8. Xu J, Pang KP , Rotenberg B. Should patients with obstruc - tive sleep apnea be screened for depression? Laryngoscope 2019;129(8):1729–1730." 3826 3975 W3123131768.pdf 2 36 separator 0.97252226 ¶ 3976 3978 W3123131768.pdf 2 37 bibliography 0.9971963 "9. Moonga SS, Mischoulon D, Winkelman JW , et al. Obstruc - tive sleep apnea as a complication of bipolar disorder and its treatment: a review and approach to management. Prim Care Companion CNS Disorders. 2017;19(6):17f02194. Published 2017 Nov 30. doi:10.4088/PCC.17f02194" 3978 4265 W3123131768.pdf 2 0 title 0.8063339 McCall and Yates Compensation following bilateral vestibular injury 0 67 W1966477239.pdf 1 1 separator 0.9798066 ¶ 67 69 W1966477239.pdf 1 2 title 0.9575453 T able 1 | Etiologies of bilateral vestibular hypofunction. 69 129 W1966477239.pdf 1 3 separator 0.8106325 ¶ 129 131 W1966477239.pdf 1 4 text 0.38823014 Ototoxic 131 140 W1966477239.pdf 1 5 title 0.41189593 140 141 W1966477239.pdf 1 6 table 0.37378564 medication 141 151 W1966477239.pdf 1 7 title 0.36192733 s 151 152 W1966477239.pdf 1 8 text 0.34129143 ( 152 154 W1966477239.pdf 1 9 table 0.3557604 e 154 155 W1966477239.pdf 1 10 title 0.3937729 . 155 156 W1966477239.pdf 1 11 text 0.3738093 g 156 157 W1966477239.pdf 1 12 title 0.37881154 . 157 158 W1966477239.pdf 1 13 text 0.38013482 , amino 158 165 W1966477239.pdf 1 14 title 0.41303355 glyco 165 170 W1966477239.pdf 1 15 text 0.35934544 sides, 170 176 W1966477239.pdf 1 16 title 0.4100487 cisplatin 176 186 W1966477239.pdf 1 17 table 0.4164314 ) 186 187 W1966477239.pdf 1 18 separator 0.5934224 ¶ 187 189 W1966477239.pdf 1 19 table 0.7400089 Idiopathic vestibular lossBilateral Meniere’s diseaseCerebellar ataxia with neuropathy and bilateral vestibular areflexiasyndrome (CANVAS) 189 327 W1966477239.pdf 1 20 separator 0.8950461 ¶ 327 329 W1966477239.pdf 1 21 table 0.79542893 "Trauma Autoimmune disease Genetic diseaseMeningitisNeurofibromatosis type 2Congenital sources" 329 426 W1966477239.pdf 1 22 separator 0.9696252 ¶ 426 428 W1966477239.pdf 1 23 text 0.9997241 "loss of vestibular inputs, as lesions can be created at a prescribed time and the effects on behavior or physiological responses can bestudied systematically. Macpherson and colleagues documentedthe effects of a bilateral labyrinthectomy on postural stability incats ( Thomson et al., 1991 ;Inglis and Macpherson, 1995 ;Stapley et al., 2006 ;Macpherson et al., 2007 ). The animals were severely impaired for the first 2 days after lesions, after which they couldstand unsupported on a tilt platform and walk in a staggering fash-ion ( Thomson et al., 1991 ). Within a week, animals could jump to and from a chair, ataxia was profoundly reduced, and locomo-tion speeds were much faster ( Thomson et al., 1991 ). Although limb muscle responses to linear translations had normal pattern-ing after the loss of vestibular inputs, hypermetria was presentfor the first 10 days ( Inglis and Macpherson, 1995 ). These obser- vations show that a rapid compensation process occurs duringthe first 7–10 days following the removal of labyrinthine signals,which then slows considerably. However, some postural deficitswere enduring. For example, balance was permanently destabi-lized when the head was turned ( Thomson et al., 1991 ;Stapley et al., 2006 ), due to the fact that at peak yaw head velocity the lesioned cats produced an unexpected burst in extensors of thecontralateral limbs that thrust the body to the ipsilateral side ( Sta- pley et al., 2006 ). The magnitude of the counterproductive limb extension was largest during the first few days after lesions, but theresponse remained present when the experiment was discontinued∼40 days after the removal of vestibular inputs." 428 2117 W1966477239.pdf 1 24 separator 0.98730254 ¶ 2117 2119 W1966477239.pdf 1 25 text 0.9997454 "Other groups have also examined the effects of a bilateral labyrinthectomy on postural responses. It was demonstrated thatlimb extension during falling, which is critical for normal landing,is permanently lost following a bilateral labyrinthectomy ( Watt, 1976 ). However, righting responses did recover over time ( Igarashi and Guitierrez, 1983 ). In addition, there were permanent impair- ments in the ability to keep to a straight course in darkness,although veering was minimal when visual cues were present(Marchand and Amblard, 1990 ). In another study, tonic activ- ity of some trunk muscles, including the abdominal musculature,remained elevated for the entire 30-day recording period followinga bilateral labyrinthectomy ( Cotter et al., 2001 ), although muscle activity was highest during the first week following lesions." 2119 2963 W1966477239.pdf 1 26 separator 0.99699223 ¶ 2963 2965 W1966477239.pdf 1 27 title 0.98523533 Autonomic effects 2965 2983 W1966477239.pdf 1 28 separator 0.99533546 ¶ 2983 2985 W1966477239.pdf 1 29 text 0.9994451 Postural alterations that place the long axis of the body below theheart, such as head-up tilts in quadrupeds or standing in man, 2985 3115 W1966477239.pdf 1 30 separator 0.91985655 ¶ 3115 3117 W1966477239.pdf 1 31 caption 0.99372435 "FIGURE 1 | Arterial blood pressure (A) and femoral artery blood flow (B) recorded in a conscious cat during a 60 ̊ head-up tilt before ( top) and a few days subsequent ( bottom ) to a combined bilateral labyrinthectomy and vestibular neurectomy. When the labyrinth was intact ( top), blood pressure remained relatively stable during the head-up rotation." 3117 3480 W1966477239.pdf 1 32 text 0.9961539 "Although femoral artery blood flow initially increased during themovement due to the effects of gravity, flow quickly dropped due toperipheral vasoconstriction. H owever, f ollowing the removal of vestibular inputs ( bottom ), a drop in blood pressure occurred at the onset of the head-up rotation. In addition, the gravity-induced increase in blood flow inthe femoral artery was larger and more prolonged, because peripheralvasoconstriction was delayed." 3480 3936 W1966477239.pdf 1 33 caption 0.94561726 "Data in (A)from Jian et al. (1999) ; data in (B) from Wilson et al. (2006) ." 3936 4015 W1966477239.pdf 1 34 separator 0.992398 ¶ 4015 4017 W1966477239.pdf 1 35 text 0.9995067 "tend to produce a reduction in venous return to the heart ( Yavor- cik et al., 2009 ) that requires rapid responses of the autonomic nervous system to avoid an alteration in blood pressure ( Rush- mer, 1976 ;Hall, 2011 ). The responses include vasoconstriction in the portion of the body below the heart to prevent periph-eral blood pooling ( Wilson et al., 2006 ;Y avorcik et al., 2009 )." 4017 4415 W1966477239.pdf 1 36 separator 0.9898437 ¶ 4415 4417 W1966477239.pdf 1 37 text 0.99926424 "The top panel of Figure 1B illustrates that in a vestibular-intact animal, blood flow to the hindlimb decreased below basal levelswithin 10 s of a sudden 60 ̊ head-up tilt. However at the onsetof the tilt, blood flow to the hindlimb increased because of theeffects of gravity; this increased blood flow would have persistedif vasoconstriction did not occur ( Wilson et al., 2006 ;Yavorcik et al., 2009 ). As a consequence of the autonomic nervous system responses during large head-up rotations, blood pressure remainsrelatively stable during the postural alteration (see Figure 1A ;Jian et al., 1999 )." 4417 5025 W1966477239.pdf 1 38 separator 0.9764519 ¶ 5025 5027 W1966477239.pdf 1 39 text 0.99951416 "Following a bilateral labyrinthectomy, the attenuation in hindlimb blood flow that ordinarily occurs during 60 ̊ head-uprotations was delayed and diminished ( Wilson et al., 2006 ;Yavor- cik et al., 2009 ), as shown in the bottom panel of Figure 1B .I n addition, blood pressure became unstable at the onset of head-up tilts ( Jian et al., 1999 ), as illustrated in the bottom panel of Figure 1A . However, these deficits were only prominent for a week after the loss of vestibular inputs, at which time blood pressurewas stable during postural alterations ( Jian et al., 1999 ). A caveat is that the animals could have expected to be tilted quite oftenwhen restrained in the rotating device, such that they were partic-ularly vigilant during the experimental sessions. Animals may notalways maintain such a high level of attention to environmentalcues regarding body position in space outside of laboratory condi-tions. Thus, BVH could result in a long lasting deficit in correcting" 5027 6019 W1966477239.pdf 1 40 separator 0.8485228 ¶ 6019 6021 W1966477239.pdf 1 41 paratext 0.9714779 Frontiers in Neurology | Neuro-otology December 2011 | Volume 2 | Article 88 | 2 6021 6102 W1966477239.pdf 1 0 text 0.76202005 1 2 W4388533925.pdf 5 1 separator 0.7557401 ¶ 1 2 W4388533925.pdf 5 2 text 0.99908906 "KHV. In general, [ 30, 31] explained that a population's genetic variation greatly influences that population's resistance to disease." 3 143 W4388533925.pdf 5 3 separator 0.9765153 ¶ 145 147 W4388533925.pdf 5 4 text 0.99962896 "The results of further analysis using Duncan's multiple range test showed that the synthetic population had a final survival rate of 62%, significantly better than the three comparison strains, which ranged from 20 -26.7%. The higher genetic variation in sy nthetic populations is thought to increase the population's resistance to KHV infection. This resulted in a markedly better synthetic population survival rate than other strains. As explained by [29], the level of heterozygosity is thought to influence the character of resistance to KHV disease infection in Majalaya carp. This is based on the research result by [32] related to the heterozygosity of the MHC I gene, particularly in the Cyca -DAB1 allele , which regulates the immune system in European common carp challenged with KHV." 147 966 W4388533925.pdf 5 5 separator 0.9892142 ¶ 968 970 W4388533925.pdf 5 6 text 0.9996369 "Another study reported that genetic variation factors play a role in stress control systems in fish [33]. This is based on a study by [34] on the channel catfish ( Ictalurus punctatus ), which stated that as many as 61 genes were expressed in various ways in the brain in response to stress. The existence of high gene variation will increase the stress response in the fish so that it can deal with changes in environmental conditions. The same condition is thought to occur in fish challenged with a disease, one of the stress -causing factors in organisms. In this study, the level of genetic variation, especially the heterozygosity of the synthetic population , which was higher than the founder population [13] , is thought to have played a major role in increasing the immune capacity of this population. The higher the immune level of a population, the better the stress response. This resulted in the population having higher resistance when challenged with KHV dis ease. Based on this result, this synthetic population of common carp has a high potential for being cultured by farmers or used as a base population for selection programs, especially for forming disease -resistant carp." 970 2201 W4388533925.pdf 5 7 separator 0.9960717 ¶ 2202 2204 W4388533925.pdf 5 8 title 0.9695611 4 Conclusion 2204 2217 W4388533925.pdf 5 9 separator 0.99706054 ¶ 2219 2221 W4388533925.pdf 5 10 text 0.99807024 "The synthetic population of common carp has a survival rate of 62%, significantly better than other carp populations . This result showed that the synthetic common carp population's establishment has succeeded in increasing carp populations' resistance to KHV infection. This synthetic population has a high potential for being cultured by farmers or used as a base population for selection programs." 2221 2629 W4388533925.pdf 5 11 separator 0.99680626 ¶ 2631 2633 W4388533925.pdf 5 12 title 0.8261411 References 2633 2644 W4388533925.pdf 5 13 separator 0.9942174 ¶ 2646 2648 W4388533925.pdf 5 14 bibliography 0.9978819 1. A. Sunarto, A. Cameron. FAO Fisheries Proceeding. 4, 87-105 (2005) 2648 2719 W4388533925.pdf 5 15 separator 0.5674737 ¶ 2721 2723 W4388533925.pdf 5 16 bibliography 0.9979215 2. A. Sunarto, A. Rukyani, T. Itami. Bull. Fish. Res. Age . 2, 15-22 (2005) 2723 2800 W4388533925.pdf 5 17 separator 0.74810815 ¶ 2802 2804 W4388533925.pdf 5 18 bibliography 0.9978996 "3. K. Syahputra, F.S. Palimirmo, Y. Himawan. J. Ris. Aku 11, 297 -305 (2017) [In Bahasa]." 2804 2899 W4388533925.pdf 5 19 separator 0.8580167 ¶ 2901 2903 W4388533925.pdf 5 20 bibliography 0.9978075 "4. D. Ariyanto, O. Carman, D.T. Soelistyowati, M.Jr. Zairin, M. Syukur. AACL Bio . 11, 1564 -1573 (2018)" 2903 3012 W4388533925.pdf 5 21 separator 0.9140871 ¶ 3014 3016 W4388533925.pdf 5 22 bibliography 0.99790007 5. M.F. Sukadi, J. Ragunan. FFTC -RCA International Workshop. 4-8 (2006) 3016 3090 W4388533925.pdf 5 23 separator 0.90725404 ¶ 3092 3094 W4388533925.pdf 5 24 bibliography 0.9979039 "6. T. Taukhid, O. Komarudin, H. Supriyadi, D. Bastiawan. The Management Strategy for KHV Disease Control. (2005) [In Bahasa ]." 3094 3226 W4388533925.pdf 5 25 separator 0.9112742 ¶ 3227 3229 W4388533925.pdf 5 26 bibliography 0.9977101 "7. Taukhid, A.M. Lusiastuti, K. Suryadi, R. Rosidah, G. Setiadharma . G. Ber. Biol. 10, 339-347 (2010)" 3229 3336 W4388533925.pdf 5 27 separator 0.8185859 ¶ 3338 3340 W4388533925.pdf 5 28 bibliography 0.99784017 8. M.B. Reantaso. FAO Aqu. News. 49, 16 (2012) 3340 3389 W4388533925.pdf 5 29 separator 0.96197355 ¶ 3391 3393 W4388533925.pdf 5 30 paratext 0.9555473 6 3393 3395 W4388533925.pdf 5 31 separator 0.89961994 ¶ 3395 3397 W4388533925.pdf 5 32 paratext 0.9719415 "E3S Web of Conferences 442, 02011 (2023) https://doi.org/10.1051/e3sconf/202344202011 ISFFS 2023" 3397 3497 W4388533925.pdf 5 0 paratext 0.98043853 Page 6/12 0 9 W3093285954.pdf 5 1 title 0.98400617 Relationship Between Urine Psep Level And Eps-lecithin 9 63 W3093285954.pdf 5 2 separator 0.9925076 ¶ 63 65 W3093285954.pdf 5 3 title 0.5215456 Corp 65 70 W3093285954.pdf 5 4 text 0.53927386 uscles 70 76 W3093285954.pdf 5 5 separator 0.7493272 ¶ 76 78 W3093285954.pdf 5 6 text 0.9778413 "Although the vitality EPS examination has been questioned in clinical practice, EPS is still widely used clinically because there is no ideal speci" 78 228 W3093285954.pdf 5 0 paratext 0.9690019 "8 Vol:.(1234567890) Scientific Reports | (2022) 12:2094 | https://doi.org/10.1038/s41598-022-05820-9" 0 112 W4210898521.pdf 7 1 separator 0.99402386 ¶ 112 114 W4210898521.pdf 7 2 text 0.97542226 "www.nature.com/scientificreports/Gene Sequences of Fungal Isolates. Identifications based on cultural features were confirmed by sequence analysis of the isolates. Basic Logical Alignment Search Tool (BLAST) results of ITS region, Beta-tubu- lin, RPB2 gene and calmodulin gene sequences of this study in National Center for Biotechnology Information (NCBI) provided relationships and similarities with reference sequences in GenBank. The amplified sequences of each gene were submitted to GenBank and their accession numbers were assigned (Table 3). The results in Table 3 revealed that most isolates had above 96% similar identity to reference sequences of GenBank." 114 796 W4210898521.pdf 7 3 separator 0.9480391 ¶ 796 798 W4210898521.pdf 7 4 text 0.9959035 "There has been little or no extensive research on identification of the Fungiusing different molecular marker approach in Nigeria. Focus has been on macroscopic and microscopic features." 798 988 W4210898521.pdf 7 5 separator 0.9719159 ¶ 988 990 W4210898521.pdf 7 6 text 0.99820566 "Phylogenetic Tree. Phylogenetic trees of the fungal isolates revealed that the isolates were clustered in grouping patterns of close resemblance. Sequences from this study are shown in red colours while sequences from GenBank are shown in black. Test of phylogeny was bootstrap of 1000 replications. Phylogenetic tree based on ITS gene revealed that the alignment matrix contained 54 nucleotide sequences with 209 positions in the final dataset. All isolates of Aspergillus and Penicillium species were clustered had cluster identity of above 95% with those from GenBank. The tree was out grouped by T. erinaceum (Fig. 3)." 990 1631 W4210898521.pdf 7 7 separator 0.98319566 ¶ 1631 1633 W4210898521.pdf 7 8 text 0.9239269 Beta-tubulin gene alignment matrix contained 52 nucleotide sequences with 19 positions in the final dataset. 1633 1742 W4210898521.pdf 7 9 separator 0.9006409 ¶ 1743 1745 W4210898521.pdf 7 10 text 0.99642843 "All the fungal species had above 85% cluster similarity with fungal species from GenBank while P . Simplicissimum was placed in the out group (Fig. 4)." 1745 1902 W4210898521.pdf 7 11 separator 0.9428738 ¶ 1902 1904 W4210898521.pdf 7 12 text 0.97362345 "Phylogenetic tree based on partial RPB2 gene revealed that the alignment matrix involved 19 nucleotide sequences with a total of 404 positions in the final dataset. The two positive isolates of Penicillium citrinum shared 90% cluster similarities with sequences from GenBank (Fig. 5)." 1904 2197 W4210898521.pdf 7 13 table 0.9963582 "LC389053 Aspergillus nige r KX231821 Aspergillus nige r MH781323 Aspergillus nige r MH614485 Aspergillus nige r Aspergillus niger isolate F10D Aspergillus niger Isolate F5 D Aspergillus niger Isolate F5 Aspergillus niger Isolate F3 D Aspergillus niger Isolate F3 LC456319 Aspergillus nige r KJ020862 Fusarium incarnatum KJ020850 Fusarium incarnatum Fusarium incarnatum isolate F8 Fusarium incarnatum isolate F8 D KT374271 Fusarium incarnatum KJ125872 Fusarium incarnatu m AB587036 Fusarium incarnatum Aspergillus flavus isolate F1 D MH180047 Aspergillus flavu s Aspergillus flavus isolate F1 MH208817 Aspergillus flavus MG825996 Aspergillus flavus MH781343 Aspergillus fumigatu s Aspergillus fumigatus isolate F16D MH781329 Aspergillus fumigatu s MG991399 Aspergillus fumigatu s MH122642 Aspergillus fumigatu s MH510846 Aspergillus fumigatu s GU981632 Penicillium simplicissimu m DQ486650 Penicillium simplicissimu m GU981631 Penicillium simplicissimu m MH724309 Penicillium citrinu m Penicillium citrinum isolate F1 9 MF176773 Penicillium citrinu m LT898243 Penicillium citrinum KT779543 Penicillium citrinum Aspergillus sydowii Isolate F7 Aspergillus sydowii Isolate F7 D Aspergillus sydowii isolate F1 8 MG991347 Aspergillus sydowi i LC367608 Aspergillus sydowi i MH781293 Aspergillus sydowi i LT798999 Aspergillus sydowi i LN898881 Aspergillus sydowi i MH208743 Aspergillus japonicu s AY820019 Aspergillus japonicu s Aspergillus niger isolate F1 0 Aspergillus japonicus isolate F2 Aspergillus sydowii isolate F18D Aspergillus fumigatus isolate F1 6 Penicillium simplicissimum isolate F2 3 Penicillium simplicissimum isolate F23D9990 100 21 26 87 99 99 99 73 85 88 99 62 88 99 24 15 19 46 31 96 0.10" 2197 4084 W4210898521.pdf 7 14 separator 0.979815 ¶ 4085 4087 W4210898521.pdf 7 15 caption 0.99308395 "Figure 4. Phylogenetic tree of partial β-tubulin gene sequences by maximum likelihood. Note: Sequences from this study are shown in red." 4087 4228 W4210898521.pdf 7 0 paratext 0.7449487 "Review of: ""Unearthing the Cultural Values" 0 42 W4386568253.pdf 0 1 title 0.5767486 of Personalities 42 59 W4386568253.pdf 0 2 paratext 0.40765512 ¶ 59 61 W4386568253.pdf 0 3 title 0.791819 "in Photorealism Portraiture: The Iconography of the Works of the" 61 128 W4386568253.pdf 0 4 paratext 0.5020768 128 129 W4386568253.pdf 0 5 title 0.8256123 Ghanaian Fine Artist, Samuel 129 157 W4386568253.pdf 0 6 paratext 0.54305047 157 158 W4386568253.pdf 0 7 title 0.4905153 Otu 158 161 W4386568253.pdf 0 8 paratext 0.867939 """" 161 162 W4386568253.pdf 0 9 separator 0.9401156 ¶ 162 164 W4386568253.pdf 0 10 contact 0.6511135 Alina-Gabriela Mihalache 164 189 W4386568253.pdf 0 11 separator 0.41402996 189 190 W4386568253.pdf 0 12 paratext 0.5388504 ¶ 1 190 193 W4386568253.pdf 0 13 contact 0.39347237 193 194 W4386568253.pdf 0 14 paratext 0.46477216 ¶ 1 194 197 W4386568253.pdf 0 15 contact 0.59270924 ¶ University of Bucharest 197 224 W4386568253.pdf 0 16 separator 0.9910214 ¶ 224 226 W4386568253.pdf 0 17 title 0.88331765 Potential competing interests: 226 257 W4386568253.pdf 0 18 separator 0.9577361 ¶ 257 259 W4386568253.pdf 0 19 text 0.99051034 No potential competing interests to declare. 260 305 W4386568253.pdf 0 20 separator 0.68449074 ¶ 305 307 W4386568253.pdf 0 21 text 0.9996294 "Probably a part of a wider research in photorealism and its use in different cultures, this paper describes a few characteristics of the genre, taking as a starting point the works of a Ghanaian artist, Samuel Out, known for his photos of political leaders having impacted the recent history of South Africa. Not aiming to engage in a synthesis or analysis of the genre, this study is still valuable for enouncing concisely the traits of photorealist portraiture: connecting visual technology with ”fine” arts, in the spirit of hypermodernity; alluding to state-of-the-art, high-resolution lenses used in photo-portraiture, etc." 307 946 W4386568253.pdf 0 22 separator 0.9146471 ¶ 947 949 W4386568253.pdf 0 23 text 0.99957603 "A deeper contextualization would have served the purpose to describe African photorealism as a genre in its own right, but even without it, the paper remains relevant due to the case studies presented (a series of graphite pencils on paper, grouped under the collection The African Story), as well as to its intention to stimulate reflection on the ethical issues of representation in African Studies." 949 1357 W4386568253.pdf 0 24 separator 0.91757643 ¶ 1357 1359 W4386568253.pdf 0 25 text 0.9995287 "The authors ”read” the portraits with the tools used for ”classic” arts, with no intention to widen the scope towards the area of intermediality or to take other theoretical challenges. Therefore, the paper stays in the comfort zone of subjective perception, written with warmth and deep understanding, as the authors identify themselves with the works of the artist (Samuel Out) and with The African Story." 1359 1773 W4386568253.pdf 0 26 separator 0.95020396 ¶ 1773 1775 W4386568253.pdf 0 27 paratext 0.954406 "Qeios, CC-BY 4.0 · Review, September 9, 2023 Qeios ID: ER0FUF · https://doi.org/10.32388/ER0FUF 1 /" 1775 1892 W4386568253.pdf 0 28 separator 0.6744886 ¶ 1892 1894 W4386568253.pdf 0 29 paratext 0.70420384 1 1894 1896 W4386568253.pdf 0 0 paratext 0.9500042 "Жамият ва инновациялар – Общество и инновации – Society and innovations Journal home page: https://inscience.uz/index.php/socinov/index" 0 152 W4393061992.pdf 0 1 separator 0.893469 ¶ ¶ 155 161 W4393061992.pdf 0 2 title 0.95089054 "Legal regulation of contractual relations for the purchase and sale of goods (works, services) in e -commerce" 161 274 W4393061992.pdf 0 3 separator 0.8898529 ¶ ¶ 276 282 W4393061992.pdf 0 4 contact 0.89608866 "Albina EZRIKH1 ¶ Tashkent State University of Law" 282 337 W4393061992.pdf 0 5 separator 0.831438 ¶ ¶ 339 345 W4393061992.pdf 0 6 title 0.9761549 ARTICLE INFO ABSTRACT 345 369 W4393061992.pdf 0 7 separator 0.95182645 ¶ ¶ 372 378 W4393061992.pdf 0 8 title 0.49766603 Article history 378 394 W4393061992.pdf 0 9 paratext 0.3837199 : 394 395 W4393061992.pdf 0 10 separator 0.45130873 ¶ 397 399 W4393061992.pdf 0 11 paratext 0.50545025 "Received January 2024 Received in revised form 15 January 2024 Accepted 2 5 February 2024 Available online 15 March 2024" 399 540 W4393061992.pdf 0 12 separator 0.9901957 ¶ 541 543 W4393061992.pdf 0 13 text 0.9979102 "This article analyzes existing problems in the legal regulation of contractual relations in the field of e -commerce. The author also analyzed statistical data regarding the development of e-commerce and performed a comparative study of the legislation of the People's Republic of China. The rapid development of information and communication technologies has contributed to the emergence of a new business environment." 545 987 W4393061992.pdf 0 14 separator 0.8938595 ¶ ¶ 989 995 W4393061992.pdf 0 15 paratext 0.9219917 "2181 -1415/© 202 4 in Science LLC. DOI: https://doi.org/10.47689/2181 -1415 -vol5 -iss2/S -pp309 -316 This is an open access article under the Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/deed.ru) Keywords: e-commerce" 995 1282 W4393061992.pdf 0 16 text 0.4543738 ", information" 1282 1299 W4393061992.pdf 0 17 paratext 0.39984778 and 1299 1303 W4393061992.pdf 0 18 text 0.41683006 ¶ communication ¶ 1304 1323 W4393061992.pdf 0 19 paratext 0.36238456 1323 1324 W4393061992.pdf 0 20 text 0.4745195 "technologies, security" 1324 1350 W4393061992.pdf 0 21 paratext 0.37148133 and 1350 1354 W4393061992.pdf 0 22 text 0.49015257 privacy, ¶ 1354 1367 W4393061992.pdf 0 23 paratext 0.42018437 1367 1368 W4393061992.pdf 0 24 text 0.4562254 e-commerce operator 1368 1387 W4393061992.pdf 0 25 paratext 0.554809 . 1387 1388 W4393061992.pdf 0 26 separator 0.9827168 ¶ ¶ 1391 1397 W4393061992.pdf 0 27 title 0.9534737 "Elektron tijorat sohasida tovarlar (ishlar, xizmatlar) oldi - sotdisi shartnomaviy munosabatlarini huquqiy tartibga solish" 1397 1525 W4393061992.pdf 0 28 separator 0.80293286 ¶ ¶ 1527 1533 W4393061992.pdf 0 29 title 0.98619556 ANNOTATSIYA 1535 1547 W4393061992.pdf 0 30 separator 0.98976636 ¶ 1550 1552 W4393061992.pdf 0 31 text 0.9961851 "Kalit so‘zlar : elektron tijorat, elektron savdo, axborot va kommunikatsiya texnologiyalari, xavfsizlik va maxfiylik, elektron tijorat operatori. Ushbu maqolada elektron tijorat sohasida shartnomaviy munosabatlarni huquqiy jihatdan tartibga solishdagi kamchiliklar ko‘rib chiqilgan. Shuningdek, elektron tijorat rivojidan kelib chiqqan holda statistik ko‘rsatkichlar tahlil qilingan hamda Xitoy Xalq Respublikasi qonunchiligi taqqoslama o‘rganib chiqildi." 1552 2046 W4393061992.pdf 0 32 separator 0.83938855 "¶ ¶" 2048 2059 W4393061992.pdf 0 33 contact 0.996483 1 Master's student, Business Law Direction, Tashkent State University of Law . E-mail: albina28011999@gmail.com 2059 2171 W4393061992.pdf 0 34 separator 0.99511254 ¶ 2173 2175 W4393061992.pdf 0 0 title 0.91393286 supporting information 0 22 W4256119085.pdf 2 1 separator 0.98233974 ¶ 22 24 W4256119085.pdf 2 2 paratext 0.9507354 sup-2 Acta Cryst. (2011). E 67, m1320 24 63 W4256119085.pdf 2 3 separator 0.99104416 ¶ 67 69 W4256119085.pdf 2 4 caption 0.92464066 Figure 1 69 78 W4256119085.pdf 2 5 separator 0.9531579 ¶ 78 80 W4256119085.pdf 2 6 caption 0.9916636 The molecular structure of (I) with displacement ellipsoids drawn at the 30% probability level. 80 176 W4256119085.pdf 2 0 paratext 0.6716088 Kremmyda et al 0 14 W2319228204.pdf 8 1 title 0.9219122 . Beyond Dizziness 14 32 W2319228204.pdf 8 2 separator 0.994622 ¶ 32 34 W2319228204.pdf 8 3 text 0.99964064 "In the PHC, vestibular-related information was likely to be locatedmoreanteriorlyandvisualinformationmoreposteri orly, althoughthisseparationwaslessevidentthanintheHC( Hufner et al., 2011b ). In the current analysis the volume changes in the PHC were located in the posterior aspects bilaterally, whi ch, accordingtothemodeldescribed,cannotdirectlybeattrib utedto thelossofvestibularinput.Thissuggeststhatacomplexnetwo rk formultisensoryinformationprocessingispresentintheHF." 34 524 W2319228204.pdf 8 4 separator 0.9966698 ¶ 524 526 W2319228204.pdf 8 5 title 0.9918846 "Measures of Hippocampal Volume and Spatial Performance" 526 583 W2319228204.pdf 8 6 separator 0.9918346 ¶ 583 585 W2319228204.pdf 8 7 text 0.9995337 "The relevance of the HF, the right side in particular, for spati al orientationandnavigationhasbeenrevealedinbothanimal and human studies ( Moser et al., 1993; Ghaem et al., 1997; Maguire et al., 1997; Gron et al., 2000; Astur et al., 2002; Hartley et al., 2003; Zhang et al., 2004 ). The patients in the present study did not differ from controls in their self-reported navigation strategies (route vs. orientation strategy), both of which were measured by the Wayfinding Scale; however, their performance in the vMWT was reduced. The GM volume of the HF did not correlate with any quantitative performance scores. Thu s, there is no proof of a direct relationship between disease-re lated hippocampal volume changes and spatial navigation deficits." 585 1355 W2319228204.pdf 8 8 separator 0.907184 ¶ 1355 1357 W2319228204.pdf 8 9 text 0.99942315 "The only correlation between performance and GM volume was found for the middle-to-posterior hippocampus, including the right posterior parahippocampus. This volume also correlated negatively with the route strategy in our entire subject coh ort." 1357 1610 W2319228204.pdf 8 10 separator 0.63612944 ¶ 1610 1612 W2319228204.pdf 8 11 text 0.9991868 "Therefore, with smaller the hippocampal size, the route strate gy becamemoredominant." 1612 1700 W2319228204.pdf 8 12 separator 0.9683157 ¶ 1700 1702 W2319228204.pdf 8 13 text 0.9996328 "The Wayfinding Scale consists of a set of questions weighted according to two different navigation strategies: orientati on and route. The orientation strategy can be thought of as monitor ing self-position information rather than external environmen tal cues (Lawton, 1994 ). Questions that are weighted toward this strategy include, but are not limited to, orientation or plac e strategies and the development of a cognitive map, which are known to be dependent on the hippocampus ( Tolman, 1948; Cheung et al., 2012 ), particularly the posterior hippocampus (Janzen and van Turennout, 2004 ). It is strange that the orientation strategy showed no positive correlation with th e hippocampus. However, previous studies showed that values from the route strategy are more sensitive to differences of gender (Lawton, 1994 ) and culture ( Lawton and Kallai, 2002 )." 1702 2589 W2319228204.pdf 8 14 separator 0.9794073 ¶ 2589 2591 W2319228204.pdf 8 15 text 0.9996162 "Questions that are weighted toward the route strategy primar ily rely on directions ( Lawton, 1994 ), e.g., turn right at the next intersection. The elderly ( Rodgers et al., 2012; Wiener et al., 2013) and women ( Lawton, 1994 ) prefer such route-, response- based strategies. The negative correlation between route- based navigation and posterior hippocampal volume could reflect this highersensitivity." 2591 3007 W2319228204.pdf 8 16 separator 0.8608967 ¶ 3007 3009 W2319228204.pdf 8 17 text 0.9994906 "On the other hand, caudate nucleus showed only a weak correlation at −6 10−0 with the route strategy, which on the wholeisconsistentwithnavigationstrategiesthatdonotd epend on environmental clues ( Bohbot et al., 2007 ). Nevertheless, it is difficulttodrawanyfurtherconclusionsbasedonthisresult ." 3009 3312 W2319228204.pdf 8 18 caption 0.86019105 "TABLE 4 | GM coordinates and cluster sizes of areas that corre late negatively with the route strategy score of the Wayfinding sc ale." 3312 3447 W2319228204.pdf 8 19 separator 0.5893212 3447 3448 W2319228204.pdf 8 20 table 0.9747935 "¶ P(uncorr) T Z Cluster size Coordinates Label WAYFINDING SCALE ROUTE STRATEGY 0.000 −5.21 −3.93 68 −28−25−17 L HC 0.000 −4.84 −3.74 44 28 −24−9 R HC 0.000 −4.70 −3.67 75 22 −36−11 R PHC" 3448 3642 W2319228204.pdf 8 21 separator 0.8100863 ¶ 3642 3644 W2319228204.pdf 8 22 table 0.61586946 Statisticalvaluesare 3644 3665 W2319228204.pdf 8 23 text 0.52035815 fromROIanalysisincludingthehippocampusand 3665 3706 W2319228204.pdf 8 24 table 0.44546175 para 3706 3711 W2319228204.pdf 8 25 text 0.49523646 hippocampus 3711 3722 W2319228204.pdf 8 26 table 0.4164645 . 3722 3723 W2319228204.pdf 8 27 separator 0.4920225 ¶ 3723 3725 W2319228204.pdf 8 28 table 0.92265046 "ROI,RegionofInterest;GM,GrayMatter;R,Right;L,Left;PHC,Parahippocam pus;HC, Hippocampus." 3725 3815 W2319228204.pdf 8 29 separator 0.98223054 ¶ 3815 3817 W2319228204.pdf 8 30 caption 0.9943034 "FIGURE 5 | The Wayfinding Scale route strategy scores correla te negatively with GM hippocampal volume bilaterally. Results are shown in a sagittal and coronal plane through the peak voxel at −28−25−17 and with the PHC GM volume on the right (not visible here). ( p<0.001 uncorr., ROI analysis of the HC and PHC bilaterally). Color bars indicate the range of t-values. The threshold for statistical significance was 3.69 . PHC, Parahippocampus; GM, Gray Matter; ROI, Region of Interest; HC , Hippocampus." 3817 4334 W2319228204.pdf 8 31 separator 0.98587596 ¶ 4334 4336 W2319228204.pdf 8 32 text 0.9996258 "Although the orientation strategy may be based more on self-position monitoring, both strategies have sensorimoto r components that require accurate vestibular information fo r successful navigation. Indeed this may partially explain why no behavioraldifferenceswerefoundbetweenourgroups.However, itisstillpossiblethatgivenlowerbetween-subjectvariabil ityand a larger sample size, differences in behavior and the resulting reductioninhippocampalvolumemaybecomeapparent." 4336 4818 W2319228204.pdf 8 33 separator 0.99622446 ¶ 4818 4820 W2319228204.pdf 8 34 title 0.99259186 Effects of Stress on Hippocampal Volumes 4820 4861 W2319228204.pdf 8 35 separator 0.9939222 ¶ 4861 4863 W2319228204.pdf 8 36 text 0.9997173 "InlightoftheincreasedspatialanxietyscoresofBVPpatient s,it is of interest that deficits of spatial memory and navigation h ave also been reported to occur in children with anxiety disorders (Mueller et al., 2009 ). Furthermore, adults with social phobias show higher cerebral blood flow in the anterior and middle hippocampal regions ( y= −13) when anticipating speaking in public(Tillforsetal.,2002 );thisareaincludestheregionshowing GM atrophy in our patients. These findings point to a two- wayinteractionbetweenanxietyandhippocampalvolumewhich involves spatial memory and navigation. Fanselow and Dong (2010)proposed that the dorsal HC is involved in information processing (spatial orientation predominantly on the right si de), and the ventral HC correlates with emotion and stress. This theory derived from evaluation of the expression of genetic markers as well as functional lesion studies. Their theory a lso supports the notion of an interaction between spatial memory andanxietywithinthehippocampus." 4863 5904 W2319228204.pdf 8 37 separator 0.9602158 ¶ 5904 5906 W2319228204.pdf 8 38 paratext 0.98323447 Frontiers in Human Neuroscience | www.frontiersin.org 9 March 2016 | Volume 10 | Article 139 5906 5999 W2319228204.pdf 8 0 paratext 0.51455796 Balneabilidade em águas doces no Brasil: riscos a 0 49 W1875864946.pdf 17 1 separator 0.45875487 ¶ 50 52 W1875864946.pdf 17 2 paratext 0.5296518 saúde, limitações metodológicas 52 84 W1875864946.pdf 17 3 bibliography 0.36598408 84 85 W1875864946.pdf 17 4 paratext 0.49742755 e operacionais 85 99 W1875864946.pdf 17 5 contact 0.94986796 "Frederico Wagner de Azevedo Lopes Antônio Pereira Magalhães Jr Eduardo Von Sperling" 99 189 W1875864946.pdf 17 6 separator 0.76338434 ¶ ¶ 190 196 W1875864946.pdf 17 7 paratext 0.92933565 "Hygeia 9 (16):28 - 47, Jun/2013 página 45 em:. Acesso em: 27/06/2012." 196 456 W1875864946.pdf 17 8 separator 0.9895551 ¶ 457 459 W1875864946.pdf 17 9 bibliography 0.9974802 "CETRON, M.S. et al. Schistosomiasis in Lake Malawi. The Lancet , 348(9037), 1274–1278, 1996." 459 556 W1875864946.pdf 17 10 separator 0.9552 ¶ 557 559 W1875864946.pdf 17 11 bibliography 0.9980505 "CHORUS, I.; BARTRAM, J. T oxic cyanobacteria in water: a guide to their publi c health consequences, monitoring e management . London: WHO, 1999. 400p." 559 714 W1875864946.pdf 17 12 separator 0.9877042 ¶ 715 717 W1875864946.pdf 17 13 bibliography 0.6047652 "CONSELHO ESTADUAL DE POLÍTICA AMBIENTAL – COPAM E C ONSELHO ESTADUAL DE RECURSOS HÍDRICOS-CER" 717 814 W1875864946.pdf 17 14 paratext 0.3963022 H 814 815 W1875864946.pdf 17 15 bibliography 0.91740775 ". Deliberação Normativa Conju nta no 01 de 05 de maio de 2008. Dispõe sobre a classificação e o enquadrament o dos corpos d’ água. Diário do Executivo - Minas Gerais- 20/05/2008. 28p." 815 1004 W1875864946.pdf 17 16 separator 0.98865 ¶ 1007 1009 W1875864946.pdf 17 17 bibliography 0.99253905 "CONSELHO NACIONAL DE MEIO AMBIENTE - CONAMA. Resolução 274 de 29 de novembro de 2000 . Estabelece condições de balneabilidade das águas brasileiras. Brasília, 2000." 1009 1181 W1875864946.pdf 17 18 separator 0.9872346 ¶ 1183 1185 W1875864946.pdf 17 19 bibliography 0.9878163 CONSELHO NACIONAL DO MEIO AMBIENTE. Resolução 357 de 17 de março de 2005 . 1185 1261 W1875864946.pdf 17 20 separator 0.97180384 ¶ 1262 1264 W1875864946.pdf 17 21 bibliography 0.654424 Estabelece a classificação, segundo os usos prepond erantes, para as águas doces, 1264 1346 W1875864946.pdf 17 22 text 0.5407204 salobras 1346 1355 W1875864946.pdf 17 23 bibliography 0.6227753 e 1355 1357 W1875864946.pdf 17 24 text 0.48539156 ¶ salinas 1358 1368 W1875864946.pdf 17 25 bibliography 0.42762598 do 1368 1371 W1875864946.pdf 17 26 text 0.41549453 terri 1371 1377 W1875864946.pdf 17 27 bibliography 0.4337768 tório 1377 1382 W1875864946.pdf 17 28 text 0.4401539 nacional 1382 1391 W1875864946.pdf 17 29 bibliography 0.5032068 . 1391 1392 W1875864946.pdf 17 30 separator 0.9881565 ¶ 1394 1396 W1875864946.pdf 17 31 bibliography 0.9899647 CONSELHO NACIONAL DO MEIO AMBIENTE. Resolução 430 de 13 de maio de 2011 . 1396 1471 W1875864946.pdf 17 32 separator 0.95825094 ¶ 1472 1474 W1875864946.pdf 17 33 bibliography 0.9347416 "Dispõe sobre as condições e padrões de lançamento d e efluentes, complementa e altera a Resolução n o 357, de 17 de março de 2005." 1474 1609 W1875864946.pdf 17 34 separator 0.99088633 ¶ 1610 1612 W1875864946.pdf 17 35 bibliography 0.99730885 "DEPARTMENT OF WATER AFFAIRS AND FORESTRY- DWAF. South African Water Quality Guidelines , Volume 2: Recreational Use, 1996. 89p." 1612 1743 W1875864946.pdf 17 36 separator 0.97195804 ¶ 1744 1746 W1875864946.pdf 17 37 bibliography 0.99764454 "DOREVITCH, S. et al. Water ingestion during water r ecreation. Water Research 4 5 , p. 2020 - 2028, 2011." 1746 1857 W1875864946.pdf 17 38 separator 0.96011126 ¶ 1858 1860 W1875864946.pdf 17 39 bibliography 0.99799055 "DUFOUR, A. P. Health effects criteria for fresh recreational wate rs . U.S. Environmental Protection Agency. Cincinnati, OH. EPA 600/1-84-004 . 1984." 1860 2013 W1875864946.pdf 17 40 separator 0.9534488 ¶ 2014 2016 W1875864946.pdf 17 41 bibliography 0.9979348 "DUFOUR, A.P. et al. Water ingestion during swimming activities in a poo l: a pilot study. J. Water Health 4 (4): 425-430, 2006." 2016 2148 W1875864946.pdf 17 42 separator 0.9548924 ¶ 2149 2151 W1875864946.pdf 17 43 bibliography 0.997951 "GILBERT, R.O. On selecting the statistical rational e for revised EPA recreational water quality criteria for bacteria. In: WYMER, L.J (Ed). Statistical framework for recreational water quality criteria and monitoring . John Willey & Sons. UK, 2007,p. 45-67." 2151 2416 W1875864946.pdf 17 44 separator 0.9794565 ¶ 2417 2419 W1875864946.pdf 17 45 bibliography 0.9973668 HEALTH CANADA-HC. Guidelines for Canadian Recreational Water Quality . Draft - 3 ed. 2419 2504 W1875864946.pdf 17 46 separator 0.6172481 ¶ 2505 2507 W1875864946.pdf 17 47 bibliography 0.99729866 Federal - Provincial-Territorial Committee on Healt h and the Environment, 2010. 153p. 2507 2594 W1875864946.pdf 17 48 separator 0.97306573 ¶ 2596 2598 W1875864946.pdf 17 49 bibliography 0.9875953 "HESPANHOL, I. Água e saneamento. In: In: REBOUÇAS, A.C; BRAGA, B.; TUNDISI, J.G. Águas doces no Brasil: capital ecológico, uso e con servação . 3 ed. São Paulo: Escrituras, 2006. p. 269-324." 2598 2797 W1875864946.pdf 17 50 separator 0.983769 ¶ 2798 2800 W1875864946.pdf 17 51 bibliography 0.9957989 "JARDIM, F.A.; MACHADO, J.N.A.;SCHEMBRI, M.C.A.C. A experiência da COPASA no monitoramento, detecção e adoção de medidas mitigad oras para as cianobactérias tóxicas em estações de tratamento de água - Minas Gerais – Bra sil. Anais... XXVII Congresso Interamericano de Engenharia Sanitária e Ambiental, ABES, 2000." 2800 3123 W1875864946.pdf 17 52 separator 0.9665042 ¶ 3124 3126 W1875864946.pdf 17 53 bibliography 0.99802345 "KAY, D. et al. Predicting likelihood of gastroenter itis from sea bathing: results from randomized exposure. The Lancet 344(8927), p. 905-909,1994." 3126 3278 W1875864946.pdf 17 54 separator 0.9670688 ¶ 3279 3281 W1875864946.pdf 17 55 bibliography 0.9977295 "KLOOS, H. et al. Water contact behaviour and schist osomiasis in an upper Egyptian village. Social Science and Medicine , 17(9), 545–562, 1983)." 3281 3429 W1875864946.pdf 17 56 separator 0.9641347 ¶ 3430 3432 W1875864946.pdf 17 57 bibliography 0.99786526 "KRISHNASWAMI, S. Health aspects of water quality. A m. J. Public Health. Assoc, n.61, p. 2259-2268, 1971." 3432 3541 W1875864946.pdf 17 58 separator 0.9809625 ¶ 3542 3544 W1875864946.pdf 17 59 bibliography 0.9980101 "LEITE, L.A.K.; NASCIMENTO,N.O.;VON SPERLING, M. Des envolvimento, utilização e análise de incertezas de modelos conceituais em Hidrologia. In: BARBOSA, F. (Org). Ângulos da água: desafios da integração . Belo Horizonte: Editora UFMG, 2008-366.p.109-156" 3544 3804 W1875864946.pdf 17 60 separator 0.9828687 ¶ 3805 3807 W1875864946.pdf 17 61 bibliography 0.99693227 "LIBANIO, M. Fundamentos de qualidade e tratamento de água . Campinas, SP: Ed. Átomo, 2.ed, 2008, 444p." 3807 3913 W1875864946.pdf 17 0 paratext 0.9871004 www.nature.com/scientificreports/9 0 34 W2599139853.pdf 8 1 separator 0.6093671 34 35 W2599139853.pdf 8 2 paratext 0.9477086 ¶ Scientific RepoRts | 7: 394 | DOI:10.1038/s41598-017-00457-5Sample 35 106 W2599139853.pdf 8 3 title 0.9452036 Collection, Processing, Bacterial Speciation and Culture Analyses. 106 173 W2599139853.pdf 8 4 text 0.99695885 "All activities con- ducted in proximity to SRKW were performed in accordance with approved animal handling protocols under NOAA and DFO permits and SARA Scientific license. A whale was approached from behind and to one side of the animal and the vessel was maneuvered to time the approach so that the petri plates attached to an aluminum pole were positioned approximately 0.4–0.6 m above the blowhole and into the exhaled plume when an orca surfaced to exhale. Between 20–50% of the approaches resulted in successful positioning to collect a sample; the success rate for collecting a breath sample during a successful approach was 100%. The identity of individual SRKWs have been catalogued for the last 40 years by the Center for Whale Research (http://www.whaleresearch.com ) and breath sampled individuals were identified by expert personnel with reference to distinct markings, pig - mentation patterns, nicks and healed scars and comparison with published catalogues" 173 1156 W2599139853.pdf 8 5 separator 0.96754575 ¶ 1156 1158 W2599139853.pdf 8 6 text 0.99961746 "40. A veterinary clinician (J. Pete Schroeder) with extensive marine mammal and cetacean medicine experience attended field sampling efforts to visually assess animals and collect breath and SML samples. Whales exhibiting signs of clinical disease or dis-tress were not approached, nor were female-calf pairs approached. No adverse or aversion behavior was noted throughout the duration of the field work. Exhaled breath samples from SRKWs were collected directly onto petri dishes to facilitate microbial isolation, subsequent bacterial and fungal identification, antibiotic sensitivity testing, metagenomics, and molecular screening for recognized pathogens." 1158 1828 W2599139853.pdf 8 7 separator 0.97297776 ¶ 1828 1830 W2599139853.pdf 8 8 text 0.99962896 "Petri plates with selective or non-selective agars were affixed to the 7.62 m long telescoping aluminum pole using suction cups (Supplementary Fig. S2 panel A). To minimize contamination by water droplets and ambient air, petri dish lids were taped at a single point to facilitate rapid opening and closing of the lids by rotating the pole. The pole with fastened petri dishes was passed through the exhaled breath plumes of surfacing SRKWs for exhaled breath sample collection (Supplementary Fig. S2 panel B). Three of the four or five attached petri dishes contained media, including Tryptone soy agar (TSA) supplemented with 2% NaCl, Columbia Blood agar and Sabouraud agar (SAB). The NaCl-supplemented media was used for recovery of halophilic microbes. After exposure to the exhaled breath, the pole was retracted and agar plates were removed, wrapped with parafilm and chilled for a maximum of 55 hours while en route to the laboratories for analysis. Upon receipt, the agar plates were incubated under varying temperatures and conditions. Columbia blood agar was incubated at 35 °C+ /−2 °C in 5–10% CO 2; TSA with 2% NaCl was incubated at 15 °C+/−2 °C and SAB agar at 30 °C+/−2 °C. Cultures were incubated for varying lengths of times and frequently observed for bacterial and fungal growth. The success rate for obtaining growth upon culturing was 100% if samples were introduced to media within the 55 hour timeframe from collection of exhalate to laboratory culturing." 1830 3340 W2599139853.pdf 8 9 separator 0.964345 ¶ 3340 3342 W2599139853.pdf 8 10 text 0.9997402 "Two empty petri dishes were also affixed to the telescoping pole to obtain exhaled breath droplets and aero - solized condensate for direct polymerase chain reaction (PCR; see below) analyses and for further microbiology and attempted virus isolation. SRKW exhaled breath samples collected on empty petri dishes were swabbed in the field with a sterile swab presoaked with sterile distilled water, then placed into either an empty sterile transport tube (for direct PCR analysis; Falcon tubes, Fisher Scientific, Pittsburgh, PA) or a sterile tube containing one of the following growth media; selenite broth, Luria Broth, Luria Broth supplemented with 3.5% NaCl, M9 mini-mal media or M9 minimal media supplemented with 3.5% NaCl. For selective enrichment for Salmonella , sam - ples inoculated into selenite broth were incubated at 42 °C+ /−2 °C for 24 hours, then transferred to XLT-4 agar and Hektoen agar and incubated at 35 °C+ /−2 °C under aerobic conditions. Suspect Salmonella colonies were sub-cultured onto Columbia blood agar for biochemical and serological testing. The remaining samples inocu- lated into growth media were transported from the field to the lab and upon arrival, were re-incubated at ambient temperature with shaking until visible turbidity was observed. Cultures were then streaked on plates containing the same growth media used for liquid growth and plates were grown for an additional 72 hours at ambient tem- perature. When necessary, cultures were re-streaked to obtain single colonies. After each sampled whale breath, control air samples were collected at the same time as the SRKW exhaled breath samples by exposing a series of agar plates described above to the air, then processed in an identical manner to breath and SML samples." 3342 5130 W2599139853.pdf 8 11 separator 0.9873287 ¶ 5130 5132 W2599139853.pdf 8 12 text 0.99963814 "To collect SML samples, sterile Plexiglas sheets were placed on the sea surface during calm sea con- ditions, and surface tension adhering water samples were transferred into sterile containers using a ster - ile squeegee and funnel (Supplementary Fig. S3). Whole water SML samples were shipped on wet ice and processed within 30 hr post-collection. On receipt at the laboratories, SML samples underwent bac-terial and fungal analysis utilizing selective and non-selective microbiological methodologies. SML samples were also submitted to an ISO 17025 accredited laboratory (I.G. MicroMed Environmental Inc, Richmond, BC) for standard colony forming units (CFU) analysis of total and fecal coliforms, Escherichia coli , Salmonella sp., Pseudomonas aeruginosa , Pseudomonas spp., Campylobacter spp., Vibrio spp., and fungi including yeast and molds using their Standards Council of Canada-approved, pro-prietary methodology (http://www.igmicromed.com/micromed-water-testing-services.html)." 5132 6136 W2599139853.pdf 8 13 separator 0.97833323 ¶ 6138 6140 W2599139853.pdf 8 14 text 0.9996249 "Aliquots from samples (SRKW exhaled breath and SML) were also inoculated into Madin Darby canine kidney (MDCK) and VERO cells using conventional techniques, incubated for 3 weeks and assessed for viral cytopathic effect (CPE)." 6140 6370 W2599139853.pdf 8 15 separator 0.9377965 ¶ 6370 6372 W2599139853.pdf 8 16 text 0.9991601 "Laboratory Analyses. Direct PCR screening (without culturing) was performed on exhaled breath samples for morbillivirus44, canine distemper virus, influenza virus45, Brucella spp46. and Mycoplasma spp. (Mollicutes)47, 48." 6372 6599 W2599139853.pdf 8 17 separator 0.85134834 ¶ 6601 6603 W2599139853.pdf 8 18 text 0.99964535 "A similar direct PCR screening approach has been used previously to identify bacteria in animal and environ- mental samples49. Bacterial and fungal identification were performed by a variety of conventional laboratory methods determined by the collaborating facility or investigator performing the analysis. Bacteria or fungal iso - lates obtained from the TSA plates supplemented with 2% NaCl, Columbia blood agar, SAB agar and Salmonella selective agar were identified based on colony morphology, growth characteristics, gram stain and biochemi-cal testing. In some instances, bacterial or fungal identification was performed using bacterial 16S rRNA and fungal 18S rRNA sequencing (broad PCR as opposed to direct PCR performed on samples without culturing" 6603 7376 W2599139853.pdf 8 0 bibliography 0.9444955 "49.Singh, K. et al. Evaluating a widely implemented proprietary deterioration index model among hospitalized patients with 581 COVID-19. Annals Am. Thorac. Soc. 18, 1129–1137, DOI: 10.1513/annalsats.202006-698oc (2021). 582" 0 225 W3204225086.pdf 21 1 separator 0.63722473 ¶ 225 227 W3204225086.pdf 21 2 bibliography 0.9774528 "50.National Institutes of Health. COVID-19 treatment guidelines panel. Coronavirus disease 2019 (covid-19) treatment 583 guidelines. https://www.covid19treatmentguidelines.nih.gov . Accessed: 2021-03-23. 584 51.Center for Disease Control. Adult Obesity Prevalence Maps. https://www.cdc.gov/obesity/data/prevalence-maps.html . 585 Accessed: 2021-05-13." 227 585 W3204225086.pdf 21 3 separator 0.87792826 586 ¶ 585 591 W3204225086.pdf 21 4 title 0.95155555 Acknowledgements 591 608 W3204225086.pdf 21 5 separator 0.8763422 587 ¶ 608 614 W3204225086.pdf 21 6 text 0.9454618 "This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory 588 under Contract DE-AC52-07NA27344 and was supported by the LLNL LDRD Program under Project No.19-ERD-009. 589 LLNL-JRNL-826855-DRAFT. An abstract based on this work was accepted for presentation at the 2021 Midwest Clinical and 590 Translational Research Meeting." 614 1005 W3204225086.pdf 21 7 separator 0.8103791 591 ¶ 1005 1011 W3204225086.pdf 21 8 title 0.97896576 Author Contributions Statement 1011 1042 W3204225086.pdf 21 9 separator 0.8514695 592 ¶ 1042 1048 W3204225086.pdf 21 10 text 0.9388737 "B.S. performed all theoretical analysis and mathematical derivations. B.S. and J.C. contributed equally to data ingestion, 593 curation, software development and study design. B.S., J.C. and P.R. contributed to experiment and study design. All authors 594 contributed to the analysis of the results and the manuscript preparation. B.S., J.C., R.C., S.N., J.M.D., S.T.H., J.H., D.J.K.," 1048 1437 W3204225086.pdf 21 11 bibliography 0.63689655 595 1437 1441 W3204225086.pdf 21 12 separator 0.94126165 ¶ 1441 1443 W3204225086.pdf 21 13 bibliography 0.9941666 D.M., P.R.: conceptualization; B.S., J.C., R.C., S.N., P.K., L.W., M.W., P.R.: data curation; B.S., J.C., R.C., S.N., P.K., L.W., 596 1443 1577 W3204225086.pdf 21 14 separator 0.54742944 ¶ 1577 1579 W3204225086.pdf 21 15 bibliography 0.99201417 M.W., P.R.: formal analysis; S.T.H., D.J.K., P.R.: funding acquisition; B.S., J.C., R.C., S.N., P.K., L.W., M.W., J.M.D., S.T.H., 597 1579 1713 W3204225086.pdf 21 16 separator 0.70885456 ¶ 1713 1715 W3204225086.pdf 21 17 bibliography 0.9851243 "J.H., D.J.K., D.M., P.R.: investigation; B.S., J.C., R.C., S.N., P.K., L.W., M.W., J.M.D., S.T.H., J.H., D.J.K., D.M., P.R.: 598 methodology; P.K., L.W., M.W., S.T.H., D.J.K., D.M., P.R.: project administration; P.K., L.W., M.W., J.M.D., S.T.H., J.H., 599" 1715 1973 W3204225086.pdf 21 18 separator 0.7658287 ¶ 1973 1975 W3204225086.pdf 21 19 bibliography 0.985883 D.J.K., D.M., P.R.: resources; B.S., J.C., R.C., S.N., P.K., L.W., M.W., P.R.: software; J.M.D., S.T.H., J.H., D.J.K., D.M., P.R.: 600 1975 2111 W3204225086.pdf 21 20 separator 0.52003944 ¶ 2111 2112 W3204225086.pdf 21 21 bibliography 0.987499 supervision; B.S., J.C., R.C., S.N., P.K., L.W., M.W., P.R.: validation, B.S., J.C., R.C., S.N., J.M.D., S.T.H., J.H., D.J.K., D.M., 601 2112 2249 W3204225086.pdf 21 22 separator 0.6419611 ¶ 2249 2251 W3204225086.pdf 21 23 bibliography 0.9822377 P.R.: writing-original draft, B.S., J.C., R.C., S.N., P.K., L.W., M.W., J.M.D., S.T.H., J.H., D.J.K., D.M., P.R.: writing, review 602 2251 2386 W3204225086.pdf 21 24 separator 0.49273705 ¶ 2386 2387 W3204225086.pdf 21 25 bibliography 0.9005485 and editing. Final version was approved by all authors. 2387 2443 W3204225086.pdf 21 26 separator 0.7962131 603 ¶ 2443 2449 W3204225086.pdf 21 27 title 0.84466773 Additional Information 604 2449 2476 W3204225086.pdf 21 28 separator 0.9415022 ¶ 2476 2478 W3204225086.pdf 21 29 title 0.98596096 Competing Interests 2478 2498 W3204225086.pdf 21 30 separator 0.7910948 605 ¶ 2498 2504 W3204225086.pdf 21 31 text 0.9850524 "The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or 606 interpretation of data; in the writing of the manuscript, or in the decision to publish the results. 607" 2504 2743 W3204225086.pdf 21 32 separator 0.9120768 ¶ 2743 2745 W3204225086.pdf 21 33 title 0.9839441 Informed Consent 2745 2762 W3204225086.pdf 21 34 separator 0.79331297 608 ¶ 2762 2768 W3204225086.pdf 21 35 text 0.9919463 "The study protocol involving analysis of fully de-identified data was reviewed and approved with Full Waiver of informed 609 consent granted (Expedited, Category #5 research) by the respective Institutional Review Board’s of ProMedica and Lawrence 610 Livermore National Laboratory. The study was performed in compliance with all regulations and guidelines from the United 611 State Department of Health and Human Services." 2768 3197 W3204225086.pdf 21 36 paratext 0.9395356 612 3197 3201 W3204225086.pdf 21 37 separator 0.9118396 ¶ 3201 3203 W3204225086.pdf 21 38 paratext 0.98490775 20/22 3203 3209 W3204225086.pdf 21 0 separator 0.9407966 ¶ 1 2 W4220726070.pdf 1 1 paratext 0.9013675 2 2 4 W4220726070.pdf 1 2 separator 0.9411293 ¶ 5 7 W4220726070.pdf 1 3 title 0.98244727 PEER C Introduction 7 27 W4220726070.pdf 1 4 separator 0.9933634 ¶ 29 31 W4220726070.pdf 1 5 text 0.9996057 "The knowledge produced by science is a public good and, as such, both the outcome of research and the evidence that supports the scientific claims ( e.g., protocols, data , models and program code ) should be transparent and publicly accessible. Open Science ( OS) is an umbrella of practices referring to the process of making scientific knowledge transparent, reproducible and accessible to everyone (Munafò et al., 2017) . Transparency and accessibility help improv e the quality and production of scientific knowledge (Crüwell et al., 2019) . In addition to the general societal and academic benefits of OS (Tennant et al., 2016) , Nawroth and Krause ( 2021) recently argued that , specifically in animal science s, OS practices also strengthen adherence to the 3Rs (Replacement, Reduction and Refinement) principles for ethical research on animals through the possibility of reus ing protocols and data , and via fast dissemination of protocols and findings . However, incorporating OS practices is still relatively limited in the animal science domain . By animal science , we refer primarily to research on domestic animals, inc luding nutritional, behavioural and physiological aspects. Breaking the barriers to engag ing with OS may require learning new skills and adopt ing new h abits. One of the major obstacles in OS engagement is the lack of institutionalised incentives and training opportunities on OS practices. Inspired by guiding papers in the domains of psychological science (Crüwell et al., 2019; Houtkoop et al., 2018) and ecology (O’Dea et al., 2021) , we here provide seven practical steps to encourage the adoption of OS in the animal science field." 31 1773 W4220726070.pdf 1 6 separator 0.9618212 ¶ 1775 1777 W4220726070.pdf 1 7 text 0.99910396 "In addition , we propose answers to some common questions related to the adoption of OS pract ices (Box 1 ) and suggest engagement actions to enhance OS in our field (Box 2)." 1777 1956 W4220726070.pdf 1 8 separator 0.9970709 ¶ 1958 1960 W4220726070.pdf 1 9 title 0.9916116 Step 1: Share your code and data 1960 1994 W4220726070.pdf 1 10 separator 0.99514055 ¶ 1996 1998 W4220726070.pdf 1 11 text 0.99968684 "Some research communities , such as those working in genomics and proteomics , have a long history of data sharing in specific repositories . However, the animal science field is still subjected to barriers to data sharing (see Box 1). If we were (more) willing and able to provide open access (OA) to our data, codes, and models, these resources could more easily be part of meta -analyses (Sielemann et al., 2020) and help ensur ing the reproducibilit y of experiments . The ‘FAIR Guiding Principles for scientific data management and stewardship’ (Wilkinson et al., 2016) describe general guidelines to improve the findability, accessibility, interoperability, and reuse (FAIR) of digital assets (see here for more information on FAIR ). One of the barriers to sharing data and code is the need to guarantee that they are stored safely and are citable ( assigned a Digital Object Identifier; DOI ). Several open research data repositories (e.g., Zenodo , Fighsare ) are available . The site re3data is a directory of the main data repositories. More recently, some research institutes have launched their own solutions to facilitate data sharing and open data publications for their researchers and collaborators ( e.g., the Portail Data INRAE , Open Agrar) . For data connected to publications, journals may impose specific repositories. In addition to data repositories, several platforms providing data services are available s uch as OpenAIRE and EOSC among others ." 1998 3532 W4220726070.pdf 1 12 separator 0.9759246 ¶ 3534 3536 W4220726070.pdf 1 13 text 0.9995803 "To follow the FAIR princ iples, it is important to add a description of your data set in the data repository. This set of information describing a data set is called metadata . It is important to use the same terms when referring to the same variables. Ontologies have been develope d for livestock phenotypic traits ( ATOL ), for lab analyses data ( JERM ) and for bioinformatics analyses ( Gene Ontolo gy)." 3536 3957 W4220726070.pdf 1 0 paratext 0.9550177 "5 Rev Bras Enferm. 2023;76(4): e20220535 6de" 0 47 W4387466628.pdf 4 1 title 0.96371657 Protocolo de organização de serviço para enfrentamento do sofrimento psíquico de universitários: uma construção coletiva 47 167 W4387466628.pdf 4 2 separator 0.9844656 ¶ 167 169 W4387466628.pdf 4 3 text 0.99224776 "Rodrigues TCMM, Barbosa GC, Tonete VLP . oferecendo recursos e suporte para a formação universitária(10), bem como possibilitando encontros periódicos de profissionais de cada campi e multicampi, para a avaliação das ações realizadas e reflexão sobre as que deveriam ser implementadas, discussão de casos e possibilidades de encaminhamentos intra e extra institucional. Sa - lienta-se que, para os estudantes que não são bolsistas, os mesmos serviços de atenção à saúde e suporte são oferecidos." 169 682 W4387466628.pdf 4 4 separator 0.8540203 ¶ 682 684 W4387466628.pdf 4 5 text 0.9996214 "Constatou-se, entretanto, que os profissionais encontram empecilhos para realizar um serviço efetivo, especialmente em relação à equipe reduzida e ao não envolvimento do conjunto de profissionais da universidade para reconhecer e enfrentar efetivamente o sofrimento psíquico. Postula-se que a gestão universitária deva ter um olhar atento em pontos-chave que precisam ser repensados e discutidos, tanto sobre a infraestrutura física quanto sobre aspectos organizacionais e de quantidade e qualificação de recursos humanos(3,6)." 684 1236 W4387466628.pdf 4 6 separator 0.88756526 ¶ 1236 1238 W4387466628.pdf 4 7 text 0.9996529 "Embora reconhecendo a grande potencialidade do trabalho reali - zado nas unidades de saúde dos quatro campi da universidade para a abordagem da saúde mental dos seus estudantes, compondo a rede de atenção à saúde psicossocial dos diferentes municípios sede, os profissionais participantes desta pesquisa-ação expressaram muitas fragilidades na estrutura das referidas redes e falta de legitimidade para os profissionais de outras áreas que não sejam exclusivas da saúde metal. Evidenciou-se, através das discussões realizadas nos encontros síncronos, que é preciso estreitar as relações com as re - des, a fim de favorecer o serviço de referência e contra-referência, buscando a integralidade da atenção à saúde dos estudantes." 1238 1994 W4387466628.pdf 4 8 separator 0.8618605 ¶ 1994 1996 W4387466628.pdf 4 9 text 0.9995313 "A partir desses dados, elaborados e discutidos pelos próprios participantes da intervenção, foi possível dimensionar a magni - tude, a transcendência, a vulnerabilidade e os determinantes do sofrimento psíquico para os estudantes, relacionando-os com suas implicações para eles e para a universidade, trazendo subsídios para a discussão e proposição do “plano de ação” ." 1996 2381 W4387466628.pdf 4 10 separator 0.84603554 ¶ 2381 2383 W4387466628.pdf 4 11 text 0.99949384 "Neste sentido, o protocolo elaborado compôs-se por uma ampla gama de atividades propostas com base em conhecimen - tos científicos e interdisciplinares e em condições institucionais concretas de serem implementadas com sucesso nos quatro campi, desde que haja respaldo da gestão e corresponsabilização dos profissionais para tal. Acrescenta-se que o protocolo, somado com as demais ações, foi indicado por todos os participantes como recurso fundamental para promover/fortalecer as ações de saúde voltadas ao enfrentamento do sofrimento psíquico." 2383 2953 W4387466628.pdf 4 12 separator 0.9288822 ¶ 2953 2955 W4387466628.pdf 4 13 text 0.99961096 "Considera-se que a realização da pesquisa-ação e de seu produto configurou-se estratégia apropriada para a promoção de ações de saúde mental que permitam o desenvolvimento cognitivo, social, cultural e emocional dos estudantes, possibilitando espaços abertos de diálogo e escuta em local que tenham oportunidade de falar e se expressar, para que possam realizar movimentos de ressignificação de si, do outro e seu contexto(1). Além disso, reafir - mou-se que a universidade deve promover ações de prevenção e tratamento de agravos à saúde mental, como o sofrimento psíquico, com intuito de possibilitar adaptações às reais necessidades da formação, sem o comprometimento das habilidades cognitivas e sócioemocionais dos universitários(2-3). Como outro aspecto positivo desta experiência, teve-se o fortalecimento do protagonismo dos profissionais na condução do planejamento das mesmas, aprovei - tando a produção de informações e aplicação de conhecimentos e estreitando as relações existentes entre a organização e sua base por meio de métodos participativos(8)." 2955 4063 W4387466628.pdf 4 14 separator 0.9196234 ¶ 4063 4065 W4387466628.pdf 4 15 text 0.99970305 "Contudo, verificou-se que em momento algum foi considerada pelos participantes da pesquisa a inclusão dos próprios estudantes e/ou de sua representação na elaboração/revisão do protocolo em construção, de modo a ampliar as possibilidades de qualificação do mesmo. Ao mesmo tempo, notou-se a pouca valorização de proposições de ações que incluíssem as famílias como foco das ações, mesmo tendo por base os problemas familiares serem a segunda causa mais prevalente de sintomas/queixas relacionados à ocorrência de sofrimento psíquico entre os universitários da instituição, aspectos que necessitam ser retomados em próximas oportunidades de revisão deste protocolo." 4065 4760 W4387466628.pdf 4 16 separator 0.99689555 ¶ 4760 4762 W4387466628.pdf 4 17 title 0.99100286 Limitações do estudo 4762 4783 W4387466628.pdf 4 18 separator 0.9921626 ¶ 4783 4785 W4387466628.pdf 4 19 text 0.998749 "A realização desta pesquisa em meio à pandemia de COVID-19 impediu a participação presencial dos profissionais na intervenção proposta, com muitas ausências nos encontros virtuais síncronos justificadas devido a essa doença ou a sobrecarga que ela trouxe. Pelo mesmo motivo, admite-se como limitação a inviabilidade da participação de estudantes ou de seus representantes, por estarem em distanciamento social, com atividades acadêmicas suspensas durante todo o trabalho de campo." 4785 5287 W4387466628.pdf 4 20 separator 0.9958114 ¶ 5287 5289 W4387466628.pdf 4 21 title 0.99180216 Contribuições para a área da saúde 5289 5324 W4387466628.pdf 4 22 separator 0.9914757 ¶ 5324 5326 W4387466628.pdf 4 23 text 0.9996859 "Acredita-se que, com a padronização das atividades a partir do protocolo elaborado, torna-se-á possível a reorientação do processo de trabalho nos departamentos de saúde e de assis - tência social da instituição universitária estudada, possibilitando, após sua concretude, a produção de impactos positivos sobre a qualidade de vida e de saúde dos estudantes, seu principal foco, com possíveis resultados que favorecerão, em última instância, os profissionais de saúde, da educação e da gestão universitária envolvidos. De forma mais ampla, espera-se que a experiência aqui relatada possa contribuir para estimular e subsidiar demais instituições universitárias a implementarem ações para o enfren - tamento do sofrimento psíquico de seus estudantes." 5326 6107 W4387466628.pdf 4 24 separator 0.9952628 ¶ 6107 6109 W4387466628.pdf 4 25 title 0.9924473 CONSIDERAÇÕES FINAIS 6109 6130 W4387466628.pdf 4 26 separator 0.9946031 ¶ 6130 6132 W4387466628.pdf 4 27 text 0.9996867 "O protocolo de organização de serviços configurou-se instru - mento de gestão imprescindível tanto para qualificar as ações já desenvolvidas visando à promoção da saúde mental, à preven - ção do sofrimento psíquico e ao atendimento dos estudantes universitários frente a esse agravo quanto para a implementação de novas ações com os mesmos propósitos. Ademais, no de - correr deste percurso, houve a oportunidade de se estabelecer aproximação de profissionais da gestão e da assistência social e da saúde intra e inter campus, facilitando o intercâmbio de suas concepções, visões e experiências na área, e fortalecendo as chances de sucesso no enfrentamento do problema em foco." 6132 6838 W4387466628.pdf 4 28 separator 0.6669756 6838 6839 W4387466628.pdf 4 29 text 0.9937588 "¶ Por fim, reconhecendo que um protocolo de cuidado após ela - borado e implementado tem validade transitória, recomendam-se sua avaliação periódica e consequente modificação, considerando as circunstâncias envolvidas, a capacidade operacional e o perfil" 6839 7101 W4387466628.pdf 4 0 paratext 0.7800569 OnlineOpen Order Form 0 21 W2937702089.pdf 0 1 separator 0.945359 ¶ ¶ 23 29 W2937702089.pdf 0 2 text 0.9289715 "Blackwell Publishing offers authors the option of ma king their article available to non-subscribers in a selection of journals online. The prepaid charge for th is service is $3,000, payable only in US Dollars. Blackwell Publishing cannot pub lish your article as OnlineOpen without receipt of this form." 29 343 W2937702089.pdf 0 3 separator 0.98946524 ¶ ¶ 345 351 W2937702089.pdf 0 4 title 0.98988366 ARTICLE INFORMATION 351 371 W2937702089.pdf 0 5 separator 0.9947696 ¶ 372 374 W2937702089.pdf 0 6 table 0.8863431 "Article Number (if known): ___________________________ Journal Title: ______________________ ¶ Article Title: ________________________________________________________________________ ¶ First named author listed on article: ____ _________________________________________________ ¶ Please select payment option ($3,000 in USD only) ¶ Cheque enclosed Purchase order (Give Purchase Order No.) ________________________ ¶ AMEX Visa Mastercard Expiry date ___________________ ¶ Credit Card No: _________________________ Signature: __________________________________ Security Code/Verification ID (3 or 4 digit # on reverse of Visa/MC or front of AMEX" 375 1159 W2937702089.pdf 0 7 separator 0.9929968 ¶ 1161 1163 W2937702089.pdf 0 8 title 0.9332477 CONTACT INFORMATION 1164 1184 W2937702089.pdf 0 9 table 0.545548 (Please print) 1185 1200 W2937702089.pdf 0 10 title 0.38051605 BILLING 1216 1224 W2937702089.pdf 0 11 table 0.42017093 ADDRESS (If 1224 1236 W2937702089.pdf 0 12 text 0.43354705 different 1236 1246 W2937702089.pdf 0 13 table 0.60769224 ) 1246 1247 W2937702089.pdf 0 14 separator 0.8779397 ¶ 1248 1250 W2937702089.pdf 0 15 table 0.85353345 "Name: _____________________________ Name: _____________________________ ¶ Univ./Org: ________ ____________ ______ Univ./Org: ___ ____________ ___________ Department: ________________________ Department: ________________________ ¶ Institute: ___________________________ Institute: ___________________________ ¶ Street: _____________________________ Street: _____________________________ ¶ City: _______________ State: _________ City: _______________ State: _________ ¶ Zip/Post code: _______________________ Zip/Post code: _______________________ ¶ Country: ___________________________" 1250 1896 W2937702089.pdf 0 16 contact 0.4942708 Country 1896 1904 W2937702089.pdf 0 17 table 0.5579529 : ___________________________ 1904 1934 W2937702089.pdf 0 18 contact 0.84417886 "¶ Phone No: _________________________ Phone No: _________________________ ¶ Email address: ______________________ Email address: ______________________" 1935 2100 W2937702089.pdf 0 19 separator 0.8316583 "¶ ¶" 2101 2111 W2937702089.pdf 0 20 title 0.98913574 TAX EXEMPTION 2111 2125 W2937702089.pdf 0 21 separator 0.99109733 ¶ ¶ 2127 2133 W2937702089.pdf 0 22 text 0.9727803 "US and Canada: Please supply your tax exemption/resale number and a valid copy of your certificate. Orders not accompanied by a certificate will result in a sales tax/GST/HST charged as applicable. Please note: by law, individuals are not eligible for tax-exempt status. Tax ex emption/resale number (if applicable): _________________________" 2133 2491 W2937702089.pdf 0 23 separator 0.83486116 ¶ 2493 2495 W2937702089.pdf 0 24 text 0.95720583 "Europe: Please supply your VAT registration number (including country); otherwise we will charge VAT as appropriate. If the number supplied is invalid, we will also charge VAT where applicable." 2495 2694 W2937702089.pdf 0 25 separator 0.9707744 ¶ 2695 2697 W2937702089.pdf 0 26 text 0.35996193 Tax 2697 2701 W2937702089.pdf 0 27 contact 0.3684816 / 2701 2702 W2937702089.pdf 0 28 table 0.39664063 GST 2702 2705 W2937702089.pdf 0 29 contact 0.38165876 / 2705 2706 W2937702089.pdf 0 30 table 0.36696175 HST 2706 2709 W2937702089.pdf 0 31 contact 0.44791144 / 2709 2710 W2937702089.pdf 0 32 table 0.35709104 VAT 2710 2713 W2937702089.pdf 0 33 contact 0.4286493 exempt ion number (if applicable):___________________ 2713 2767 W2937702089.pdf 0 34 separator 0.9441649 ¶ 2768 2770 W2937702089.pdf 0 35 contact 0.9748661 "Please return your completed form to: Lisa Hann an, The Scripps Research Institute - IMM-34, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA" 2771 2923 W2937702089.pdf 0 36 separator 0.9961194 ¶ 2925 2927 W2937702089.pdf 0 0 text 0.9987351 "perceived to be lacking something that needs to be “fixed’’in order to be successful in school and society. This belief, forwarded in the work of Payne (2005) and taken up by others in the late 1990s and early 2000s, has been the topic of critique (see Brannon et al. 2008)." 0 279 W4388633288.pdf 20 1 separator 0.99311376 ¶ 279 281 W4388633288.pdf 20 2 text 0.99850523 "The second Discourse model, also known as the American Discourse model of “success ”or“getting ahead ”, is deeply ingrained in United States society and its educational system (D ’Andrade 1984). The American Discourse model of “success ”or “getting ahead ”is grounded in the belief that if one has an ability and works hard and has a strong drive to achieve high goals, “one will reach a level of accomplishment ” and will “be recognized as a success, which brings prestige and satisfaction ” (D’Andrade 1984: 95)." 281 808 W4388633288.pdf 20 3 separator 0.9825772 ¶ 808 810 W4388633288.pdf 20 4 text 0.9996682 "Both Discourse models primarily focus on the individual ’s role and re- sponsibility in achieving a level of performance that ultimately conforms to the norms and practices of the dominant culture that will, according to their proponents, afford the student success in school and in life. This focus on the individual ’s re- sponsibility for achieving success, which is determined by conformity to the norms of the dominant culture seems related to Bourdieu ’s (1977) idea that “the education system demands of everyone alike that they have what it does not give ”(494). And further, his concept of cultural capital seems applicable to the discussion about the relationship of sAE to SWARE and Yup ’ik." 810 1528 W4388633288.pdf 20 5 separator 0.9920031 ¶ 1528 1530 W4388633288.pdf 20 6 text 0.999729 "In SW Alaska, both Yup ’ik and sAE carry cultural capital within their own contexts. Fluency in Yup ’ik or having the ability to speak/understand some Yup ’ik is cultural capital in embodied state —both in Yup ’ik culture, especially in those com- munities that still have fluent speakers, and within the Indigenous language revi- talization and language maintenance movements. As part of such movements in Alaska, many communities seek to teach Yup ’ik in schools even if it is as a second language. Speaking Yup ’ik is the “ideal ”for many communities. Yet, local language shift has resulted in the breakdown of intergenerational language transmission thereby interrupting language learning through socialization and necessitatingacquisition through conscious labor. Thus, for many communities, language in an institutionalized (western) setting may be deemed necessary for maintaining Yup ’ik language and culture." 1530 2467 W4388633288.pdf 20 7 separator 0.9826452 ¶ 2467 2469 W4388633288.pdf 20 8 text 0.9994432 "Being able to read, write and speak standardized American English also carries cultural capital in the embodied state. As discussed above, sAE is the language of ‘ success ’in the U.S. and in SW Alaska, both in terms of job and educational attainment." 2469 2727 W4388633288.pdf 20 9 separator 0.91631925 ¶ 2727 2729 W4388633288.pdf 20 10 text 0.99971956 "As such, sAE is the language of instruction in the majority of schools in the U.S. In Alaska, as in much of the U.S., the choice of medium of instruction is up to the local school and/or community. However, and as national educational policy makes clear,regardless of the medium of instruction the school must demonstrate continued suc- cess through sAE (Marlow 2004; Wyman et al. 2010). Thus, while there are no explicit" 2729 3157 W4388633288.pdf 20 11 paratext 0.8333898 188 3157 3160 W4388633288.pdf 20 12 separator 0.9892373 ¶ 3160 3162 W4388633288.pdf 20 13 paratext 0.74395037 Marlow et al. 3162 3176 W4388633288.pdf 20 0 paratext 0.98984927 Healthcare 2016 ,4, 68 3 of 5 0 29 W2518826104.pdf 2 1 separator 0.563914 29 30 W2518826104.pdf 2 2 paratext 0.95999664 ¶ Healthcare 2016 , 4, x 3 of 5 30 61 W2518826104.pdf 2 3 separator 0.9791765 ¶ 62 64 W2518826104.pdf 2 4 text 0.9112009 "aR2 = 0.47; p = 0.03) and 28 –31 week group (R = 0.73; aR2 = 0.48; p = 0.02) but no change in the 32 –36 week group (R = 0.52; aR2 = 0.18; p = 0.12). From AIHW Australia" 65 239 W2518826104.pdf 2 5 paratext 0.4355246 ’ 239 240 W2518826104.pdf 2 6 text 0.58825314 s Mothers and Babies series. 240 268 W2518826104.pdf 2 7 separator 0.98026264 ¶ ¶ 270 276 W2518826104.pdf 2 8 table 0.93131125 "Year R = 0.895 aR2 = 0.776 p < 0.005" 276 322 W2518826104.pdf 2 9 separator 0.89943755 ¶ ¶ 324 330 W2518826104.pdf 2 10 caption 0.97484267 "Figure 2. Overall incidence rate of cervical cerclage (procedures per 1000 births) in Australia for th e period 2004 until 2013." 330 463 W2518826104.pdf 2 11 separator 0.76678187 "¶ ¶" 465 475 W2518826104.pdf 2 12 table 0.5075235 477 478 W2518826104.pdf 2 13 separator 0.6196527 ¶ 478 479 W2518826104.pdf 2 14 table 0.96817195 "Year  < 25 years  25 – 34 years  > 34 years" 479 534 W2518826104.pdf 2 15 separator 0.8616874 ¶ ¶ 536 542 W2518826104.pdf 2 16 caption 0.94910574 "Figure 3. Maternal age -stratified incidence rates for cervical cerclage (procedures per 1000 births) in Australia for the" 542 669 W2518826104.pdf 2 17 text 0.9902087 "period 2004 until 2013. There was no incr ease in the rate of cerclage in the age group less than 25 years across the study period (R = 0.46; aR2 = 0.11; p = 0.19), but significant increases since 2007 in the 25 to 34 year age group (R = 0.84; aR2 = 0.67; p = 0.002) and the 35 years and older age group (R = 0.99; aR2 = 0.96; p < 0.005)." 669 1026 W2518826104.pdf 2 18 separator 0.99586755 ¶ 1028 1030 W2518826104.pdf 2 19 title 0.9875412 4. Discussion 1030 1044 W2518826104.pdf 2 20 separator 0.9927566 ¶ 1046 1048 W2518826104.pdf 2 21 text 0.9905968 "This study of national trends in Australia demonstrates that, since the release of the RANZCOG guideline for the prevention of preterm birth in 2007 , there has been a significant increase in the incide nce rate of cervical cerclage in Australia, in women 25 years of age and older. This is a direct contrast to data from the United States which shows a fall in the use of cerclage [8]. Despite this increase and greater availability of progesterone vehicles, there has been no reduction in the incidence of early preterm birth in Australia." 1048 1606 W2518826104.pdf 2 22 separator 0.53332293 ¶ 1608 1610 W2518826104.pdf 2 23 text 0.99484307 "Preterm birth occurs in about 6% –8% of all births in Australia and up to 10% of all pregnancies worldwide, with no evidence of any decrease in the rate in recent years [1,2, 10]. Perinatal" 1610 1804 W2518826104.pdf 2 24 separator 0.99343157 ¶ 1805 1807 W2518826104.pdf 2 25 caption 0.9692603 "Figure 2. Overall incidence rate of cervical cerclage (procedures per 1000 births) in Australia for the period 2004 until 2013." 1807 1937 W2518826104.pdf 2 26 separator 0.93868047 ¶ 1937 1939 W2518826104.pdf 2 27 paratext 0.9679304 Healthcare 2016 , 4, x 3 of 5 1939 1969 W2518826104.pdf 2 28 separator 0.989898 ¶ 1970 1972 W2518826104.pdf 2 29 text 0.7143725 "aR2 = 0.47; p = 0.03) and 28 –31 week group (R = 0.73; aR2 = 0.48; p = 0.02) but no change in the 32 –36 week group (R = 0.52; aR2 = 0.18; p = 0.12). From" 1973 2132 W2518826104.pdf 2 30 bibliography 0.6381569 AIHW Australia’s Mothers and Babies series. 2132 2176 W2518826104.pdf 2 31 separator 0.96085525 ¶ ¶ 2178 2184 W2518826104.pdf 2 32 table 0.96984524 "Year R = 0.895 aR2 = 0.776 p < 0.005" 2184 2230 W2518826104.pdf 2 33 separator 0.82741386 ¶ ¶ 2232 2238 W2518826104.pdf 2 34 caption 0.9730099 "Figure 2. Overall incidence rate of cervical cerclage (procedures per 1000 births) in Australia for th e period 2004 until 2013." 2238 2371 W2518826104.pdf 2 35 separator 0.62437826 "¶ ¶" 2373 2383 W2518826104.pdf 2 36 table 0.505554 2385 2386 W2518826104.pdf 2 37 separator 0.6958588 ¶ 2386 2387 W2518826104.pdf 2 38 table 0.98128307 "Year  < 25 years  25 – 34 years  > 34 years" 2387 2442 W2518826104.pdf 2 39 separator 0.82745945 ¶ ¶ 2444 2450 W2518826104.pdf 2 40 caption 0.9661782 Figure 3. Maternal age -stratified incidence rates for cervical cerclage (procedures per 1000 births) in ¶ 2450 2559 W2518826104.pdf 2 41 text 0.97835946 "Australia for the period 2004 until 2013. There was no incr ease in the rate of cerclage in the age group less than 25 years across the study period (R = 0.46; aR2 = 0.11; p = 0.19), but significant increases since 2007 in the 25 to 34 year age group (R = 0.84; aR2 = 0.67; p = 0.002) and the 35 years and older age group (R = 0.99; aR2 = 0.96; p < 0.005)." 2559 2934 W2518826104.pdf 2 42 separator 0.9951026 ¶ 2936 2938 W2518826104.pdf 2 43 title 0.95644546 4. Discussion 2938 2952 W2518826104.pdf 2 44 separator 0.977723 ¶ 2954 2956 W2518826104.pdf 2 45 text 0.98862416 "This study of national trends in Australia demonstrates that, since the release of the RANZCOG guideline for the prevention of preterm birth in 2007 , there has been a significant increase in the incide nce rate of cervical cerclage in Australia, in women 25 years of age and older. This is a direct contrast to data from the United States which shows a fall in the use of cerclage [8]. Despite this increase and greater availability of progesterone vehicles, there has been no reduction in the incidence of early preterm birth in Australia." 2956 3514 W2518826104.pdf 2 46 separator 0.6019866 ¶ 3516 3518 W2518826104.pdf 2 47 text 0.9934794 "Preterm birth occurs in about 6% –8% of all births in Australia and up to 10% of all pregnancies worldwide, with no evidence of any decrease in the rate in recent years [1,2, 10]. Perinatal" 3518 3712 W2518826104.pdf 2 48 separator 0.9930645 ¶ 3713 3715 W2518826104.pdf 2 49 caption 0.9589377 "Figure 3. Maternal age-stratified incidence rates for cervical cerclage (procedures per 1000 births) in Australia for the period" 3715 3845 W2518826104.pdf 2 50 text 0.9445975 "2004 until 2013. There was no increase in the rate of cerclage in the age group less than 25 years across the study period (R = 0.46; aR2= 0.11; p= 0.19), but significant increases since 2007 in the 25 to 34 year age group (R = 0.84; aR2= 0.67; p= 0.002) and the 35 years and older age group (R = 0.99; aR2= 0.96; p< 0.005)." 3845 4175 W2518826104.pdf 2 51 separator 0.99553 ¶ 4175 4177 W2518826104.pdf 2 52 title 0.93223786 4. Discussion 4177 4191 W2518826104.pdf 2 53 separator 0.9705932 ¶ 4191 4193 W2518826104.pdf 2 54 text 0.9985517 "This study of national trends in Australia demonstrates that, since the release of the RANZCOG guideline for the prevention of preterm birth in 2007, there has been a significant increase in the incidence rate of cervical cerclage in Australia, in women 25 years of age and older. This is a direct contrast to data from the United States which shows a fall in the use of cerclage [ 8]. Despite this increase and greater availability of progesterone vehicles, there has been no reduction in the incidence of early preterm birth in Australia." 4193 4743 W2518826104.pdf 2 55 separator 0.7236315 ¶ 4743 4745 W2518826104.pdf 2 56 text 0.99395657 "Preterm birth occurs in about 6%–8% of all births in Australia and up to 10% of all pregnancies worldwide, with no evidence of any decrease in the rate in recent years [ 1,2,10]. Perinatal complications arising from preterm birth are well-recognised and include admission for neonatal intensive care," 4745 5050 W2518826104.pdf 2 0 paratext 0.9389475 „Hatás és ellenhatás” – A fiatalok európai mobilitásának hatása... 19 0 69 W2772629446.pdf 10 1 separator 0.9947966 ¶ 69 71 W2772629446.pdf 10 2 text 0.99797267 "A centrumországok csoportjában a bejövő fiatalok mobilitásának fokozó- dása szintén csökkenti a fiatalok munkanélküliségi rátáját, kiszűrve az egyéb gazdasági és társadalmi tényezők hatását. A bejövő fiatalok mobilitásának1 százalékos emelkedése a modell alapján átlagosan 0,1 százalékponttal csök-kenti a fiatalok munkanélküliségi rátáját. Ezen kívül az egy főre jutó GDP, az FDIGDP-hez képesti aránya és a városi népesség aránya is egyenesen aránylik a fia-talok munkanélküliségéhez." 71 561 W2772629446.pdf 10 3 separator 0.96676457 ¶ 561 563 W2772629446.pdf 10 4 text 0.99868345 "A periféria országaiban a bejövő fiatalok mobilitásának emelkedése szintén csökkenti a fiatalok munkanélküliségi rátáját. Valamennyi vizsgált gazdaságiindikátor (egy főre jutó GDP, FDI-intenzitás, reál minimálbér) fordítottan ará-nyos a fiatalok munkanélküliségével, míg a városi népesség aránya és a felnőttlakosság iskolai végzettsége egyenesen arányos vele." 563 926 W2772629446.pdf 10 5 separator 0.996465 ¶ 926 928 W2772629446.pdf 10 6 title 0.99122524 AbejövőmobilitáshatásaazegyfőrejutóGDP-re 928 970 W2772629446.pdf 10 7 separator 0.99245477 ¶ 970 972 W2772629446.pdf 10 8 text 0.9986042 "A bejövő mobilitásnak a gazdasági növekedésre gyakorolt hatása esetén a determi - nációs együttható (R2) mindhárom országcsoportnál 90% fölötti. Az R2magyarázó erejével azonban ez esetben is óvatosan kell bánni. A Durbin–Watson-statisztikaértékei 2 közelében alakulnak, így feltételezhető, hogy nincs az adatsorban auto - korreláció. A VIF mutató értéke minden vizsgálatba bevont változó esetén 10 alattmaradt, így egyetlen változót sem kellett a modellből a multikollinearitás miatt ki - zárni. (A részletes eredményeket lásd a 2. mellékletben.)" 972 1531 W2772629446.pdf 10 9 separator 0.9686929 ¶ 1531 1533 W2772629446.pdf 10 10 text 0.99234474 "Az összes vizsgált ország esetén a bejövő fiatalok mobilitásának fokozódása növeli az egy főre jutó GDP-t, kiszűrve az egyéb gazdasági (FDI-intenzitás és reál" 1533 1694 W2772629446.pdf 10 11 caption 0.97865677 3. ábra: A fiatalok bejövő mobilitásának a munkanélküliségre gyakorolt hatását leíró modell 1694 1786 W2772629446.pdf 10 12 separator 0.4800434 ¶ 1786 1787 W2772629446.pdf 10 13 caption 0.9942953 Model results of mobility’s impact on young people unemployment rate 1787 1856 W2772629446.pdf 10 14 separator 0.995656 ¶ 1856 1858 W2772629446.pdf 10 0 paratext 0.97976065 "4E3S Web of Conferences 107, 01006 (2019) https://doi.org/10.1051/e3sconf/201910701006 ICSREE 2019" 0 101 W2955894575.pdf 3 1 separator 0.98177356 ¶ 102 104 W2955894575.pdf 3 2 title 0.99339825 "4.1 Method of determining the qualitative index measure standards" 104 173 W2955894575.pdf 3 3 separator 0.9941905 ¶ 175 177 W2955894575.pdf 3 4 text 0.9987462 "For the qualitative index assessment of the comprehensive assessment index system of new energy development, the industry experts will consider the actual conditions of an enterprise and assessment elements, and use five -level measure standards to assess each index (as shown in Table 2)." 177 482 W2955894575.pdf 3 5 separator 0.9971899 ¶ 483 485 W2955894575.pdf 3 6 title 0.91534996 Table 2. Measure Standard of Qualitative Index of New Energy 485 546 W2955894575.pdf 3 7 table 0.7215231 "¶ Comprehensive Assessment . Excellent Good Moderate Bad Worse [0.8,1.0] [0.7,0.8) [0.6,0.7) [0.5,0.6) [0,0.5)" 547 668 W2955894575.pdf 3 8 separator 0.9950938 ¶ 669 671 W2955894575.pdf 3 9 title 0.9931952 "4.2 Method of determining the quantitative index measure standards" 671 741 W2955894575.pdf 3 10 separator 0.9950372 ¶ 743 745 W2955894575.pdf 3 11 text 0.9993903 "Sample selection: owing to the different basic conditions, application environment, industry demand, etc. of new energy development, the new energy development scales of different provinces vary a lot together with apparently variant technical characteristics. Therefore, it is hard to select one or several provinces as the examples. In sampling, the whole country should be treated as a general example." 745 1166 W2955894575.pdf 3 12 separator 0.87257445 ¶ 1168 1170 W2955894575.pdf 3 13 text 0.9995292 "Measure standards: in the specific assessment of quantitative indices, the method of average is adopted to determine the measure standard value of each index, i.e. calculation of the relevant indices nationally. Such standards are more accurate and referential. The three - year indices of 2016- 2018 are calculated and the mean value or development trend is taken as the standard to determine the upper limit and lower limit of index, thus providing more accurate reference to the new energy development assessment of a certain province." 1170 1727 W2955894575.pdf 3 14 separator 0.99697983 ¶ 1729 1731 W2955894575.pdf 3 15 title 0.9933207 5 Determination of index weights 1731 1764 W2955894575.pdf 3 16 separator 0.9960698 ¶ 1766 1768 W2955894575.pdf 3 17 text 0.99956816 "Determination of index weights is a critical step of comprehensive assessment of new energy development that decides the accuracy of assessment result. The AHP and expert comments are adopted to calculate the weights of the first layer assessment indices —energy production, energy consumption and policy mechanism, get the expert's pairwise comparison judgment matrix of index importance, calculate the index weights by AHP, and make reference to the expert comments in the system to optimize and adjust the index weight value so as to finalize the weights." 1768 2342 W2955894575.pdf 3 18 separator 0.9973633 ¶ 2344 2346 W2955894575.pdf 3 19 title 0.9932529 "5.1 Establish an index system of hierarchical structure" 2346 2405 W2955894575.pdf 3 20 separator 0.9943174 ¶ 2407 2409 W2955894575.pdf 3 21 text 0.9992264 "The assessment indices are classified by membership relation as the objective layer, criteria layer and index layer to form the dominance relation from top to bottom, i.e. hierarchical structure." 2409 2614 W2955894575.pdf 3 22 title 0.9907955 "5.2 Build a judgment matrix of pairwise comparison" 2615 2669 W2955894575.pdf 3 23 separator 0.99201965 ¶ 2671 2673 W2955894575.pdf 3 24 text 0.99927735 "After establishment of comprehensive index system of hierarchical structure, for the index factor of the upper layer, select the relevant sub -index in the lower layer for pairwise comparison of importance and bu ild the judgment matrix." 2673 2923 W2955894575.pdf 3 25 separator 0.997071 ¶ 2925 2927 W2955894575.pdf 3 26 title 0.99234504 5.3 Calculate comprehensive weight 2927 2962 W2955894575.pdf 3 27 separator 0.9955584 ¶ 2964 2966 W2955894575.pdf 3 28 text 0.99622905 "Calculate the vector W of index and sequence the order of index importance. The weight value yielded by the judgment matrix is the separate weight value of index corresponding to its factor on the immediate upper layer. Therefore, these separate weight val ues need to be combined into the comprehensive weight value of index corresponding to the top layer. After the unification, 1j jy can be satisfied (as shown in Table 3 )." 2966 3420 W2955894575.pdf 3 29 separator 0.82286215 ¶ 3421 3423 W2955894575.pdf 3 30 text 0.9994545 "For the setting of second -layer index weight, as there are too man y indices, the AHP -based judgment matrix calculation may incur some problem of effectiveness and thus the calculation result of AHP method is corrected by expert comment." 3423 3672 W2955894575.pdf 3 31 separator 0.99746 ¶ 3674 3676 W2955894575.pdf 3 32 title 0.9078661 "Table 3. Comprehensive Assessment Index Weight of New Energy Development " 3676 3756 W2955894575.pdf 3 33 table 0.5242137 . 3756 3757 W2955894575.pdf 3 34 separator 0.88785905 ¶ 3758 3760 W2955894575.pdf 3 35 table 0.99431616 "1st layer index and weight 2nd layer index 2nd layer weight Energy production (0.54) Share of new energy installed capacity 0.20 Share of incremental installed capacity of new energy 0.40 New energy installed capacity per capita 0.20 New energy installed capacity per unit GDP 0.20 Energy consumption (0.16) Share of new energy power in total power consumption 0.42 New energy power output per capita 0.23 New energy power output per unit GDP 0.12 Ratio of wind power curtailment and photovoltaic power curtailment 0.23 Policy mechanism (0.3) Industry development 0.14 Incentive policy 0.29 Development planning 0.29 Administrative rules 0.29" 3760 4530 W2955894575.pdf 3 36 separator 0.99347675 ¶ 4532 4534 W2955894575.pdf 3 37 title 0.9875376 "6 Case study of application in Jiangsu Province" 4534 4585 W2955894575.pdf 3 38 separator 0.9950955 ¶ 4587 4589 W2955894575.pdf 3 39 text 0.9973953 "On the basis the new energy development data of Jiangsu Province in 2018 , the comprehensive assessment of overall development level of new energy in Jiangsu" 4589 4753 W2955894575.pdf 3 0 paratext 0.96315134 "International Journal for Multidisciplinary Research (IJFMR) ¶ E-ISSN: 2582 -2160 ● Website: www.ijfmr.com ● Email: editor@ijfmr.com ¶ IJFMR2306 9594 Volume 5, Issue 6, November -December 2023 5 " 0 223 W4389146651.pdf 4 1 separator 0.80811614 ¶ ¶ 223 228 W4389146651.pdf 4 2 text 0.9987712 "It is also to be observed that the custody rights are given to a major sibling, if the both the parents are unfit, but the same has to be established in front of the court." 228 405 W4389146651.pdf 4 3 separator 0.77000296 ¶ ¶ 407 413 W4389146651.pdf 4 4 title 0.9903566 10. CUSTODY OF A CHILD; IF ONE PARENT RE -MARRIES: 413 464 W4389146651.pdf 4 5 separator 0.98470306 ¶ 466 468 W4389146651.pdf 4 6 text 0.9923634 "The custodial rights of a person does not get affected if one parent re -marries. The remarriage of the custodial parent brings a lot of changes in the child's world and can have both positive and negative impact. If the child is more adversely negatively i mpacted, the non -custodial parent can demand for custody modification. On the other hand, if the non -custodial parent remarries, it does not create an adverse effect. But if it is observed that the position of the non -custodial parent has been improved on the re -marriage, they might also be allowed for more visitation rights. If the nationality of the custody parent is different as that of the child, it has to be adhered as stated in the case of Navtej Singh v. State of NCT of Delhi. " 468 1245 W4389146651.pdf 4 7 separator 0.7928207 ¶ ¶ 1245 1250 W4389146651.pdf 4 8 title 0.98504853 11. MOTHER : A BETTER CARE -TAKER; IS IT A MYTH ? 1250 1300 W4389146651.pdf 4 9 separator 0.98371756 ¶ 1301 1303 W4389146651.pdf 4 10 text 0.99173623 "In India, it is always presumed that mothers are better care -takers, but it is not the case every -time. Fathers also have equal interest in the custody of the child but there are cases where the mothers are given priority. Certain statutes such as sec6 of the Hindu Minority and guardianship Act 1956, support the same. But with cases coming up and the recent judgement by the Bombay High court on September14,2023, breaks this myth. The judgment clearly stating that “the best interest of child cannot be solely based on Mother’s affection and care.” " 1303 1876 W4389146651.pdf 4 11 separator 0.8443188 ¶ ¶ 1876 1881 W4389146651.pdf 4 12 title 0.9922995 12. CUSTODY RIGHTS IN CASE OF TWINS OR SIBLINGS: 1881 1930 W4389146651.pdf 4 13 separator 0.98819435 ¶ 1932 1934 W4389146651.pdf 4 14 text 0.9997358 "Though the basic principle applies in the circumstance where there is an involvement of two children or more in the process of custody. It is often advised and also looked onto by the court that the twins are not separated in the case of physical custody. This is so to avoid further emotional scares that might occur due to the separation. One of the factors that is looked on to and evaluated while giving the custody is the relationship that exist between the siblings. As if there is a rift between the sibli ngs and if the court finds that it it is best for the children to live apart, the same verdict is delivered. The sex of the child is also one factor that is taken into consideration when giving the custody decision to the parents." 1934 2696 W4389146651.pdf 4 15 separator 0.86341524 ¶ ¶ 2698 2704 W4389146651.pdf 4 16 title 0.98612803 13. SUGGESTIONS: 2704 2721 W4389146651.pdf 4 17 separator 0.99364746 ¶ 2723 2725 W4389146651.pdf 4 18 text 0.9982959 "The concept of shared parenting is yet not been discussed or brought up in India. Majority of the cases have physical custody, where one parent has the sole custody, whereas the other has just the visiting rights. This in turn brings up many issues, thus the recognition of joint custody is a must. And it is also important to take the psychological aspect into account because parents have the ability to easily influence their children's thoughts. And parents frequently use this to their advantage, which eventually causes anguish for their kids." 2725 3291 W4389146651.pdf 4 19 separator 0.7393645 ¶ 3293 3295 W4389146651.pdf 4 20 text 0.99955696 "The frequent switching of parents, particularly in the early years, before the age of five, causes a severe psychological wound. Guidelines with respect to the step -parents custody must be properly framed. This is to avoid complexities in the future and fo r the smooth process." 3295 3581 W4389146651.pdf 4 21 separator 0.9927758 ¶ 3583 3585 W4389146651.pdf 4 22 text 0.9765372 "The stand of transgender people in the aspect of custody: It is to be noted that the marriage between transgenders have been legalized in India and they have the capacity to adopt a child under Sec41(6) of the Juvenile Justice Act. Thus, there is a need fo r the legislation to take action regarding the custody of" 3585 3906 W4389146651.pdf 4 0 title 0.9609167 Early and Lasting Effects of the Incorporation of X-Ray into Chiropractic 127 0 79 W2504725163.pdf 18 1 separator 0.9923389 ¶ 79 81 W2504725163.pdf 18 2 text 0.9997246 "method must fi t his model of disease and treatment, which was central and necessarily rigid. There were three unchanging boundaries to B.J.’s health care ideology: First, the concept that ‘Innate Intelligence’ used mental impulses, carried by nerves, to direct the functions of the body; second, the ability of tiny displacements of vertebrae to interfere with the nerve transmission of these mental impulses; and third, that manipulation of vertebrae could remove this interference, and the consequent normalisation of body function would result in the restoration of health. Both D.D. and B.J. exhibited a progressive attitude to their profession, changing parts of chiropractic over time as they acquired new knowledge, developed new theories, or found new technologies. D.D.’s approach seems to have been theoretical. He continued to evolve his ideas of the mechanism of disease, but never the root aetiology; he maintained that ninety- fi ve percent of disease was caused by subluxated vertebrae and the other fi ve percent by subluxations of peripheral joints. He also never changed his method of diagnosis—manual palpation only—nor the cure for disease—i.e. adjusting subluxated joints. In contrast, B.J. was more practical. His desire to market chiropractic seems to have allowed him more leeway in altering the boundaries of the profession. The X-ray also served this purpose, bringing in the public to help boost converts to his method of healing. He augmented the numbers of people coming through the doors in October 1910 by opening his X-ray laboratory to the public for radiography of any condition. Prior to this it had only been for spinography for chiropractic analysis on patients attending the clinic at the school." 81 1823 W2504725163.pdf 18 3 separator 0.9761904 ¶ 1823 1825 W2504725163.pdf 18 4 paratext 0.87620133 84 1825 1828 W2504725163.pdf 18 5 separator 0.9885681 ¶ 1828 1830 W2504725163.pdf 18 6 text 0.9986006 "Although still a staunch promoter of minute displacements of spinal bones as crucial to overall health, it seems that external forces eventually forced the pragmatic B.J. to change. In 1950, the Palmer School had had to give up teaching solely his HIO (Hole-in-One) theory 85 because Palmer School graduates were increasingly unable to pass state licensing board exams.86 In addition, in 1958 a group of prominent and active chiropractors with an interest in radiology set up a radiology certi fi cation examination through the National Chiropractic Association’s National Council on Chiropractic Roentgenology (NCCR). This group evolved to become the American Chiropractic College of Radiology (ACCR), an educational body, and the American Chiropractic Board of Radiology (ACBR), who administered the exam and certi fi ed chiropractic radiologists. These chiropractors emphasised the diagnostic use of X-ray imaging, but early on still acknowledged a role for chiropractic analysis." 1830 2835 W2504725163.pdf 18 7 separator 0.96873456 ¶ 2835 2837 W2504725163.pdf 18 8 paratext 0.9736823 87 Times 2837 2846 W2504725163.pdf 18 9 separator 0.522431 ¶ 2847 2849 W2504725163.pdf 18 10 paratext 0.97300196 This content downloaded from 130.95.106.69 on Wed, 27 Jul 2016 01:21:17 UTC 2849 2925 W2504725163.pdf 18 11 separator 0.66398114 ¶ 2926 2928 W2504725163.pdf 18 12 paratext 0.9422371 All use subject to http://about.jstor.org/terms 2928 2976 W2504725163.pdf 18 0 paratext 0.9504841 Lányi Gusztáv: Sorskérdéseinkről. Kor- és kórdiagnózisaimból 153 0 64 W4386896563.pdf 4 1 separator 0.9911336 ¶ 64 66 W4386896563.pdf 4 2 text 0.9837889 "Nem csoda, ha „mindez megtörtént”: Isten részéről „minden rendben” – ám „ré - szünkről annál kevésbé. A helyzet ezért pocsék és ezért tart még a történelem.” (Balás, 2014, 2)" 66 246 W4386896563.pdf 4 3 separator 0.9890785 ¶ 247 249 W4386896563.pdf 4 4 text 0.9924802 "A történelemnek tehát koránt sincs vége. Sőt! Most kezdődik csak igazán – a keresztény (politikai) identitásépítés is: a SZERETET EREJÉVEL. A hívő ember ugyanis az események sodrában „nem viselkedhet hűvös nézőként, avagy eszement rajongóként. (...) A világot, s benne az egyháztörténelmet utólag ugyan leírjuk, de előbb magunk alakítjuk.” (Balás, 2021, 18)" 249 620 W4386896563.pdf 4 5 separator 0.9971334 ¶ 620 622 W4386896563.pdf 4 6 title 0.9862554 Szent István és eucharisztia 622 651 W4386896563.pdf 4 7 separator 0.993201 ¶ 651 653 W4386896563.pdf 4 8 text 0.9497994 2021. augusztus 15–20. – szeptember 5–12. 653 695 W4386896563.pdf 4 9 separator 0.77398264 ¶ 695 697 W4386896563.pdf 4 10 text 0.9590219 "Megváltó jelenlét: „Az Úr nem ment el, itt maradt. Őbelőle táplálkozunk. Óh különös, szent, nagy titok! (...) a mi királyunk, Krisztus, nem halott! A mi királyunk eleven! (Babits, 1938)" 697 893 W4386896563.pdf 4 11 separator 0.99323326 ¶ 893 895 W4386896563.pdf 4 12 text 0.82473755 A mi magyar királyunk is eleven? 895 928 W4386896563.pdf 4 13 separator 0.9891772 ¶ 928 930 W4386896563.pdf 4 14 text 0.98245853 Egy elgondolkoztató történeti, politikai, pszichológiai és pszicho-teológiai párhuzam. – 930 1019 W4386896563.pdf 4 15 separator 0.5246113 ¶ 1021 1023 W4386896563.pdf 4 16 text 0.9980408 "Jean Marie Lustiger (1926–2007), Párizs bíboros érseke egyik előadásában a követke - zőket mondta: „A történelemben két népnek a fennmaradása valóságos csoda. Ez a két nép a zsidóság és a magyarság. A zsidók a mózesi törvény megszabta elkülönülésük - nek, illetve teljes különállóságuknak, a magyarok pedig a keresztény népekhez való csatlakozásuknak köszönhetik fennmaradásukat.” (Jakab, 2021)" 1023 1428 W4386896563.pdf 4 17 separator 0.9966997 ¶ 1428 1430 W4386896563.pdf 4 18 title 0.9817079 Magyar és/vagy keresztény 1430 1456 W4386896563.pdf 4 19 separator 0.99574554 ¶ 1456 1458 W4386896563.pdf 4 20 text 0.97377104 A Szent István-napi igéből idézek: 1458 1493 W4386896563.pdf 4 21 separator 0.8583601 ¶ 1493 1495 W4386896563.pdf 4 22 text 0.98294353 "Hallgasd meg, fiam, fogadd el szavaimat, akkor megsokasodnak életed esztendei. Megmutatom neked a bölcsesség útját, egyenes lesz az út, amelyen vezetlek. Semmi sem gátolja lépteidet, amikor jársz, és ha gyorsan szaladsz, akkor sem botlasz meg. Tartsd meg intelmemet, ne tágíts tőle! Őrizd meg, hiszen ez a te életed! Ne lépj a gonoszok ösvényére, és a gonosztevők útján ne járj! Hagyd el s ne menj rajta tovább, kanyarodj el tőle, úgy folytasd utadat!" 1495 1957 W4386896563.pdf 4 23 separator 0.88801444 ¶ 1957 1959 W4386896563.pdf 4 24 text 0.9960429 "Az igaz ember útja olyan, mint a hajnal pirkadása, amely egyre világosabb, míg fényes nap - pal nem lesz." 1960 2068 W4386896563.pdf 4 0 paratext 0.98858726 Int. J. Environ. Res. Public Health 2019 ,16, 1992 11 of 14 0 59 W2948796520.pdf 10 1 separator 0.99451256 ¶ 59 61 W2948796520.pdf 10 2 text 0.999662 "It is known that meteorological and land surface factors affect the production, dispersion and distribution of pollen in the atmosphere [ 45,46]. Various studies in the past have shown the relation between pollen distribution and meteorological factors using machine learning methods. For example, the relation between air temperature and pollen was shown by [ 26,47]. Refs. [ 20,48] showed the relation between pollen concentration, precipitation and atmospheric wind, respectively. However, a comprehensive model involving plant phytosociology, habitat, phenology and meteorological variables is needed to effectively estimate and forecast the atmospheric allergic pollen concentration in the ambient atmosphere over a large spatial area." 61 816 W2948796520.pdf 10 3 separator 0.97842443 ¶ 816 818 W2948796520.pdf 10 4 text 0.9997237 "Previous studies have employed machine learning methods and meteorological variables to model allergic pollen abundance. For example, Csépe et al. [21] used multilayer perceptron neural networks and other tree algorithms to predict ragweed pollen abundance over Szeged (Hungary) and Lyon (France) using daily mean, maximum, minimum and range temperatures, daily mean wind speed, air pressure, total radiation and relative humidity and serial number of the day in the given year as predictor variables. Csépe et al. [21] found that the the daily total radiation (for Lyon) and the daily mean, max and range temperatures (for Szeged) are the most influential meteorological variables. Puc [26] used artificial neural networks and meteorological factors to estimate allergic pollen and showed that relative humidity and maximum temperature are the most important variables." 818 1703 W2948796520.pdf 10 5 separator 0.95774114 ¶ 1703 1705 W2948796520.pdf 10 6 text 0.99968547 "Nowosad et al. [49] used different statistical methods including linear models, non-linear models such as neural networks and support vector machines and regression tree methods for different places and different pollen species. Nowosad et al. [49] used eleven meteorological variables including maximum, minimum, and mean temperatures, vapor pressure, wind speed precipitations, growing degree days, etc and found that growing degree days is the most important variable for all the three pollen species." 1705 2218 W2948796520.pdf 10 7 separator 0.9809364 ¶ 2218 2220 W2948796520.pdf 10 8 text 0.9995068 "Identifying the most important predictor variables would help us to optimize our machine learning models to forecast pollen. In general, the list of important features varies on geographic location and the type of pollen species we are estimating." 2220 2472 W2948796520.pdf 10 9 separator 0.75492406 ¶ 2472 2474 W2948796520.pdf 10 10 text 0.9994791 In this research we used twenty-three predictor variables for our machine learning methods. 2474 2566 W2948796520.pdf 10 11 separator 0.7312573 ¶ 2566 2568 W2948796520.pdf 10 12 text 0.99964786 "The variables are time lagged by 1 to 30 days so that the total number of predictor variables becoming 3123. We trained the machine learning before and after lagging the variables. The random forest was applied to estimate the variable importance. We found that the surface albedo, soil temperature and total column ozone are among the top most predictor variables. Time lagging of the variables shows that the surface albedo nine to 10 days prior are the most influential predictors." 2568 3061 W2948796520.pdf 10 13 separator 0.9517934 ¶ 3061 3063 W2948796520.pdf 10 14 text 0.9996639 "However, pollen abundance is a complex function of weather, land surface and air transport and its modelling is challenging. The pollen distributions commonly exhibited large day to day variations which are hard to capture in machine learning models. Back-trajectory analysis showed that large day to day variations of pollen abundance are associated with directional air movement [34]." 3063 3456 W2948796520.pdf 10 15 separator 0.9572444 ¶ 3456 3458 W2948796520.pdf 10 16 text 0.9995589 "Future studies should include variables carrying information about the directional air parcel movement in order to of improve allergic pollen forecasting. Variables derived from back and forward trajectory analysis, Ref. [ 44] could improve in forecasting the challenging abrupt large scale day day variations in the pollen abundance." 3458 3799 W2948796520.pdf 10 17 separator 0.99622256 ¶ 3799 3801 W2948796520.pdf 10 18 title 0.9891423 5. Conclusions 3801 3816 W2948796520.pdf 10 19 separator 0.99660695 ¶ 3816 3818 W2948796520.pdf 10 20 text 0.999671 "In this study we used advanced machine learning (random forest, extreme gradient boosting and deep neural networks) to forecast the airborne abundance of Ambrosia pollen. For comparison we also used the linear Bayes ridge machine learning model. The Ambrosia pollen used to supervise the machine learning methods was measured at University of Tulsa, Oklahoma (1987–2017) using a Burkard trap. The environmental context used by the machine learning models to estimate the airborne pollen concentration were from ECMWF reanalysis data. This environmental context was also time lagged from between 1–30 days to examine the role of the recent historical environmental context on estimate the airborne pollen abundance." 3818 4547 W2948796520.pdf 10 0 text 0.9994671 "SEURAT-1 [6], and ARCH-Tox [7]. Overviews of these projects were presented at the 9th World Congress on Al- ternatives and Animal Use in the Life Sciences (WC9) in 2014 [8], and each is expected to have an impact on future safety assessment of chemicals." 0 262 W1679027516.pdf 2 1 separator 0.9797084 ¶ 262 264 W1679027516.pdf 2 2 text 0.99911267 "In USA, Tox21 pools federal resources and expertise from the Environmental Protection Agency (EPA), National Institutes of Environmental Health Sciences/National Toxicology Program, National Institutes of Health, Na- tional Center for Advancing Translational Sciences, and the Food and Drug Administration in a program that utilizes robotics technology to screen thousands of che- micals for potential toxicity, using screening data to pre- dict the potential toxicity of chemicals and developing a cost-effective approach for prioritizing the thousands of chemicals that need toxicity testing. The Tox21 consor- tium leverages its partners ’resources and expertise to p r e d i c tm o r ee f f e c t i v e l yh o wac o l l e c t i o no f1 0 , 0 0 0 compounds comprising env ironmental chemicals and approved drugs will affect human health and the environment." 264 1155 W1679027516.pdf 2 3 separator 0.98158133 ¶ 1155 1157 W1679027516.pdf 2 4 text 0.999687 "A major part of the EPA ’s CompTox research is the Toxicity Forecaster (ToxCast TM) [5], which is a multi-year effort launched in 2007 that uses automated chemical screening technologies, known as high-throughput screening assays, to expose living cells or isolated pro- teins to chemicals. The cells or proteins are then screened for changes in biological activity that may sug- gest potential toxic effects and eventually potential ad- verse health effects. These innovative methods have the potential to limit the number of required laboratory animal-based toxicity tests while quickly and efficiently screening large numbers of chemicals." 1157 1821 W1679027516.pdf 2 5 separator 0.9858213 ¶ 1821 1823 W1679027516.pdf 2 6 text 0.9992367 "In the European Union, there is an ongoing long-term strategic initiative called the Safety Evaluation Ultimately Replacing Animal Testing [6], or SEURAT-1, to promote the intermediate steps that have to be taken before the final goal can be reached. SEURAT-1 will develop know- ledge and technology building blocks required for the development of solutions to replace the current repeated dose systemic toxicity in vivo testing used for the assess- ment of human safety. The SEURAT-1 Research Initia- tive comprises six research projects, which will run for five years, starting on January 1, 2011. These projects promote close cooperation toward a common goal and combine the research efforts of over 70 European uni- versities, public research institutes, and companies." 1823 2623 W1679027516.pdf 2 7 separator 0.9197147 ¶ 2623 2625 W1679027516.pdf 2 8 text 0.9992063 "Collaboration between these six research projects, dis- semination of their results, cooperation with other inter- national research teams, and continuous updating of research priorities will be facilitated by a related coord- ination and support action project called “COACH ”." 2625 2912 W1679027516.pdf 2 9 separator 0.9849943 ¶ 2912 2914 W1679027516.pdf 2 10 text 0.99919754 "A project in Japan called ARCH-Tox for the Future Chemicals Management Policy: Research and Developmentof in vitro and in vivo Assays for Internationally Leading Hazard Assessment and Test Methods is being supported by the Ministry of Economy, Trade and Industry (METI) [7]. This project aims to establish in vitro test methods for speedily and efficiently assessing the endpoint of 28-day re- peated dose toxicities, hepatotoxicity, nephrotoxicity and neurotoxicity, and will promote close cooperation toward a common goal and combine the research efforts of six or more Japanese universities, public research institutes, and companies." 2914 3572 W1679027516.pdf 2 11 separator 0.9866685 ¶ 3572 3574 W1679027516.pdf 2 12 text 0.9995453 "Also, the OECD continues its efforts to make better use of increased knowledge on the means by which che- micals induce adverse effects in humans and wildlife through Adverse Outcome Pathways (AOPs) [9]. Its ef- forts are based on knowledge of effective tools for identi- fying chemicals that need to be regulated. AOPs provide insight into how chemicals induce adverse effects through toxicity pathways and modes of action. Since 2012, the AOP Development Programme at the OECD has been pioneering the establishment of a comprehen- sive AOP framework for the effective use of mechanistic information in regulatory decision-making." 3574 4228 W1679027516.pdf 2 13 separator 0.9629041 ¶ 4228 4230 W1679027516.pdf 2 14 text 0.9993643 "As a major step forward towards this goal, joint collab- oration between the OECD, EPA, and the European Commission Joint Research Centre launched the Ad- verse Outcome Pathway Knowledge Base (AOP KB)." 4230 4438 W1679027516.pdf 2 15 separator 0.87184125 ¶ 4438 4440 W1679027516.pdf 2 16 text 0.9992884 "This is a web-based platform which aims to bring to- gether all knowledge on how chemicals can induce adverse effects, thereby providing a focal point for AOP development and dissemination. The first AOP KB module is the AOP Wiki: an interactive and virtual encyclopedia for AOP development, structured in ac- cordance with the original OECD guidance document and template for developing and assessing adverse out- come pathways (Series No. 184, Series on Testing and Assessment) [10] and the more recent Handbook for AOP developers [11]." 4440 4999 W1679027516.pdf 2 17 separator 0.99701536 ¶ 4999 5001 W1679027516.pdf 2 18 title 0.98538184 “Introduction of ICH and recent topics related to safety ” 5001 5060 W1679027516.pdf 2 19 separator 0.95196617 ¶ 5060 5062 W1679027516.pdf 2 20 title 0.4560014 by 5062 5065 W1679027516.pdf 2 21 contact 0.38771436 Dr 5065 5068 W1679027516.pdf 2 22 title 0.39581817 . 5068 5070 W1679027516.pdf 2 23 contact 0.44943437 Hiroshi Onodera, 5070 5086 W1679027516.pdf 2 24 title 0.3440017 5086 5087 W1679027516.pdf 2 25 contact 0.37630558 Pharmaceuticals 5087 5102 W1679027516.pdf 2 26 title 0.3982083 and Medical 5102 5115 W1679027516.pdf 2 27 contact 0.34962034 ¶ 5115 5116 W1679027516.pdf 2 28 title 0.47037968 5116 5117 W1679027516.pdf 2 29 contact 0.39444306 Devices Agency 5117 5131 W1679027516.pdf 2 30 separator 0.99364746 ¶ 5131 5133 W1679027516.pdf 2 31 text 0.9211702 "The development of novel medicines must focus on pro- viding patients with safe and effective drugs on a global scale. The marketing of a drug necessitates the regula- tory approval of the target country or region. However, since the documents and/or testing protocols required for registration may differ for each country/region, a considerable amount of time and energy might be re- quired, which could result in a drug lag. From the view- point of animal welfare, it is important to avoid the unnecessary duplication of animal testing protocols. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a framework, which standardizes" 5133 5869 W1679027516.pdf 2 32 paratext 0.9601346 Kojima and Kasamatsu Genes and Environment (2015) 37:12 Page 3 of 9 5869 5937 W1679027516.pdf 2 0 paratext 0.9587928 "International Journal for Multidisciplinary Research (IJFMR) ¶ E-ISSN: 2582 -2160 ● Website: www.ijfmr.com ● Email: editor@ijfmr.com ¶" 0 155 W4385425271.pdf 15 1 separator 0.5033114 ¶ 157 159 W4385425271.pdf 15 2 paratext 0.9798307 IJFMR2304 4315 Volume 5, Issue 4, July -August 2023 16 159 216 W4385425271.pdf 15 3 separator 0.93267775 ¶ ¶ 217 223 W4385425271.pdf 15 4 text 0.92834675 "sustainability: profitability to maintain and expand services without continued injections of subsidized donor funds, Efficiency; performance in controlling the administrative costs. These are general measures in which the performance should be considered and these can be further elaborated in detail based on (Ledger Wood, 1999) ." 223 565 W4385425271.pdf 15 5 separator 0.9967786 ¶ 566 568 W4385425271.pdf 15 6 title 0.9934942 2.1.9 Sustainability of MFIs 568 597 W4385425271.pdf 15 7 separator 0.9953828 ¶ 599 601 W4385425271.pdf 15 8 text 0.9996313 "In micro -finance, sustainability can be considered at several levels of institutional, group, and individual and can relate to organizational, managerial, and financial aspects (Rao, 2001)) as cited by (Kimando, 2012) . However, the issue of financial sustainability of microfinance institutions has attracted more attention in mainstream analysis for its contribution to poverty reduction. Sustainability is loosely defined as the ability of a MFI to co ver its operating and other costs from generated revenue and provide for profit. It is an indicator which shows how the MFI can run free of subsidies (Melkamu, 2012) . This change in emphasis has created a different perspectiv e on the analysis of performance of the MFIs." 601 1349 W4385425271.pdf 15 9 separator 0.9521676 ¶ 1350 1352 W4385425271.pdf 15 10 text 0.99941516 "Today many key players in the industry use sustainability as one core criteria to evaluate the performance of MFI besides the outreach other impact measures described earlier." 1352 1531 W4385425271.pdf 15 11 separator 0.94977844 ¶ 1533 1535 W4385425271.pdf 15 12 text 0.99963176 "According to Meyer, (2012), there are two kind of sustainability that we could observe in assessing MFIs sustainability: financial self -sufficiency and Operational self - sufficiency. Financial self - sustainability is when MFIs can also cover the costs of funds and other forms of subsidies received when they are valued at market prices. A more popular definition of financial self -sustainability suggested by Micro -Banking Bulletin, CGAP, Mix Market and others by which financial sustainability is defined as total adjusted revenue as a percent of total adjusted expenses such that the result should be greater than or equal to 100%. On the other hand operational self -sufficiency is when the operating income is sufficient enough to cover operational costs like salaries, supplies, loan losses, and o ther administrative costs." 1535 2396 W4385425271.pdf 15 13 separator 0.9127849 ¶ 2398 2400 W4385425271.pdf 15 14 text 0.99957734 "Thus, as mentioned by AEMFI, (2014),financial sustainability is MFIs’ ability to cover all costs on adjusted bases and indicate its capability to operate without ongoing subsidies including soft and grants." 2400 2610 W4385425271.pdf 15 15 separator 0.9348459 ¶ 2611 2613 W4385425271.pdf 15 16 text 0.9995019 "The adjustment goes t o inflation, loan loss provisioning and cost of capital. Meyer, (2012) believed that financial self -sufficiency is a high standard measure of sustainability and brings long term perspectives for MFI operations than operational self -sufficiency. According t o him the poor needed to have access to financial service on long -term basis rather than just a one -time financial support." 2613 3029 W4385425271.pdf 15 17 separator 0.97079813 ¶ 3031 3033 W4385425271.pdf 15 18 text 0.99603903 "Microfinance is said to be an effective instrument discovered in 21st century to mitigate rural poverty in the world (Ramanaiah & Mangala, 2011)" 3033 3181 W4385425271.pdf 15 19 separator 0.984321 ¶ 3183 3185 W4385425271.pdf 15 20 text 0.9996369 "In the early days when MFIs established their finance was from donation or grants from those donors who have set their goal as eradication or reduction of poverty. Diverse literatures noted that sustainability is one of the areas that need to be assessed to enhance the full functioning of microfinance institutions. This brought the need for MFIs to be measured on how much MFI reach to the poor and how far the lives of those who get financial services are changing a s compared to those who don’t get these services. But as the MF industry grows in size, the need for increased financing coupled with unpredictability of donor funds trigger the issue of building a sustainable MFIs that stand on their own leg." 3185 3920 W4385425271.pdf 15 21 separator 0.97374517 ¶ 3922 3924 W4385425271.pdf 15 22 text 0.9995243 "According t o the explanation of Meyer (2002) also stated that the financial un -sustainability in the MFI arises due to un -materialization of funds promised by donors or governments. Hence MFIs shall start covering their own cost of operation from their program revenu es. Thus we can loosely define sustainability as the ability of an MFI to cover its operating and other costs from generated revenue and" 3924 4341 W4385425271.pdf 15 0 paratext 0.98674196 PISSN 2087 – 5576; EISSN 2579 – 3454 Vol. 8 No. 2, Juli 2018 0 63 W3124809300.pdf 5 1 separator 0.9714817 ¶ ¶ 65 71 W3124809300.pdf 5 2 paratext 0.8631306 32 Jurnal Ilmiah Hospitality Management 71 111 W3124809300.pdf 5 3 separator 0.9966973 ¶ 113 115 W3124809300.pdf 5 0 bibliography 0.99203056 "Sousa, M. O., Boyle, R., Bonito, J. (2010). Avaliação de Diferentes Adubações na Cultura da Vinagreira (Hibiscus sabdariffa, L.). Millenium, 39: 153‐ 161." 0 164 W2144447380.pdf 7 1 separator 0.9776608 ¶ ¶ 165 172 W2144447380.pdf 7 2 text 0.99869496 "Para a variável matéria seca (MS), os resultados obtidos não foram significativos (Tabela 9) entre os tratamentos, portanto quando aplicados o teste de Tukey (Tabela 10) não obtiveram diferença estatística entre si." 172 394 W2144447380.pdf 7 3 separator 0.8674906 "¶ ¶" 395 405 W2144447380.pdf 7 4 title 0.8034515 Tabela 9 - Teste F para a variável “matéria seca”. 405 456 W2144447380.pdf 7 5 separator 0.9698095 ¶ 457 459 W2144447380.pdf 7 6 table 0.983684 "Fonte de Variação GL Soma de Quadrado Quadrado Médio F Signif. Tratamentos 5 .8906946 .1781389 2.549 .09784 Repetições 2 .1777778 .8888892 .127 Resíduos 10 .6988890 .6988890 CV 65.635 ¶" 459 678 W2144447380.pdf 7 7 separator 0.9765898 ¶ 680 682 W2144447380.pdf 7 8 table 0.46416372 Tabel 682 688 W2144447380.pdf 7 9 title 0.43858388 a 688 689 W2144447380.pdf 7 10 table 0.4548102 10 689 693 W2144447380.pdf 7 11 title 0.618136 - Teste Tuke y para a variável “ matéria seca ”. 693 741 W2144447380.pdf 7 12 separator 0.99204713 ¶ 742 744 W2144447380.pdf 7 13 table 0.9802341 "TRATAMENTO Médias Comparações T1 .0567 A T2 .0000. A T3 .0533 A T4 .0650 A T5 .0433 A T6 .0233 A" 744 863 W2144447380.pdf 7 14 separator 0.6982187 ¶ 864 866 W2144447380.pdf 7 15 text 0.60465777 "* Para cada média, letras minúsculas iguais indicam que as médias de comparações não diferem entre si, pelo teste de Tukey ao nível de 1% e 5% de probabilidade." 866 1031 W2144447380.pdf 7 16 separator 0.9929793 ¶ ¶ 1032 1038 W2144447380.pdf 7 17 title 0.9854274 Conclusão 1038 1048 W2144447380.pdf 7 18 separator 0.9963069 ¶ 1049 1051 W2144447380.pdf 7 19 text 0.9992564 "As doses de nutrientes testadas induzira m efeitos significativos sobre a altura da planta (AP), quantidade de frutos por planta s (QFP), e matéria verde da parte aérea (MV), destacando-se o T4 (Figura 2) que respondeu muito bem a adubação com uso de NPK com cobertura de N, demonstrando melhor média estatística para todas as variáveis analisadas, altura da planta, quantidade de frutos, como ta mbém na quantidade de massa verde; a matéria seca não revelou significância em nenhuma das variáveis analisadas." 1051 1573 W2144447380.pdf 7 20 separator 0.58602756 ¶ 1575 1580 W2144447380.pdf 7 21 text 0.38253543 ¶ 1580 1581 W2144447380.pdf 7 22 separator 0.3989556 1583 1584 W2144447380.pdf 7 23 text 0.26790348 ¶ 1584 1585 W2144447380.pdf 7 24 separator 0.24304746 1587 1588 W2144447380.pdf 7 25 math 0.26552805 ¶ 1588 1589 W2144447380.pdf 7 26 paratext 0.21983624 1591 1592 W2144447380.pdf 7 27 math 0.28342485 ¶ 1592 1593 W2144447380.pdf 7 28 table 0.23595208 1595 1596 W2144447380.pdf 7 29 math 0.28948024 ¶ 1596 1597 W2144447380.pdf 7 30 table 0.2558863 1599 1600 W2144447380.pdf 7 31 math 0.29338428 ¶ 1600 1601 W2144447380.pdf 7 32 table 0.26843095 1603 1604 W2144447380.pdf 7 33 math 0.29756215 ¶ 1604 1605 W2144447380.pdf 7 34 table 0.27697575 1607 1608 W2144447380.pdf 7 35 math 0.29897317 ¶ 1608 1609 W2144447380.pdf 7 36 table 0.27558464 1611 1612 W2144447380.pdf 7 37 math 0.29759505 ¶ 1612 1613 W2144447380.pdf 7 38 table 0.26494822 1615 1616 W2144447380.pdf 7 39 math 0.29057702 ¶ 1616 1617 W2144447380.pdf 7 40 separator 0.29006845 1619 1620 W2144447380.pdf 7 41 math 0.27079356 ¶ 1620 1621 W2144447380.pdf 7 42 separator 0.7649848 "¶ ¶" 1623 1633 W2144447380.pdf 7 43 caption 0.99434304 Figura 2. Altura da planta e frutificação do T4 . 1633 1684 W2144447380.pdf 7 44 separator 0.98946816 ¶ 1685 1687 W2144447380.pdf 7 45 paratext 0.91887164 160 1689 1693 W2144447380.pdf 7 0 paratext 0.9777743 Open Peer Review on Qeios 0 25 W2465825417.pdf 0 1 separator 0.6822064 ¶ 25 27 W2465825417.pdf 0 2 paratext 0.93073726 Open Peer Review on Qeios 27 53 W2465825417.pdf 0 3 separator 0.89704955 ¶ 53 55 W2465825417.pdf 0 4 title 0.79408246 Medical Oncologist 55 74 W2465825417.pdf 0 5 separator 0.7085295 ¶ 74 76 W2465825417.pdf 0 6 paratext 0.48396155 National 76 85 W2465825417.pdf 0 7 title 0.5022994 Cancer Institute 85 102 W2465825417.pdf 0 8 separator 0.9784634 ¶ 102 104 W2465825417.pdf 0 9 paratext 0.72123885 Source 104 111 W2465825417.pdf 0 10 separator 0.793465 ¶ 111 113 W2465825417.pdf 0 11 paratext 0.5426953 National Cancer Institute. 113 140 W2465825417.pdf 0 12 separator 0.33457044 141 142 W2465825417.pdf 0 13 paratext 0.47783554 ¶ Medical Oncologist 142 162 W2465825417.pdf 0 14 bibliography 0.2696389 162 163 W2465825417.pdf 0 15 paratext 0.24907021 ¶ 163 164 W2465825417.pdf 0 16 bibliography 0.37629533 164 165 W2465825417.pdf 0 17 paratext 0.48862964 . NCI Thesaurus. Code C17838. 165 194 W2465825417.pdf 0 18 separator 0.9939338 ¶ 194 196 W2465825417.pdf 0 19 text 0.9953125 "A doctor who specializes in treating cancer. Some oncologists specialize in a particular type of cancer treatment. For example, a radiation oncologist specializes in treating cancer with radiation." 196 398 W2465825417.pdf 0 20 separator 0.9848138 ¶ 398 400 W2465825417.pdf 0 21 paratext 0.949189 "Qeios · Definition, February 2, 2020" 400 444 W2465825417.pdf 0 22 separator 0.5855562 ¶ 444 446 W2465825417.pdf 0 23 paratext 0.94580036 "Qeios ID: OQPYIR · https://doi.org/10.32388/OQPYIR 1 /" 446 509 W2465825417.pdf 0 24 separator 0.8309789 ¶ 509 511 W2465825417.pdf 0 25 paratext 0.6288023 1 511 513 W2465825417.pdf 0 0 paratext 0.8443631 23 0 2 W4378378413.pdf 22 1 separator 0.9737698 ¶ ¶ 3 10 W4378378413.pdf 22 2 paratext 0.84783936 References 520 10 26 W4378378413.pdf 22 3 separator 0.9053782 ¶ ¶ 27 33 W4378378413.pdf 22 4 bibliography 0.9973401 "Alas, H. D. C., Weinhold, K., Costabile, F., Di Ianni, A ., Müller, T., Pfeifer, S., Di Liberto, L., Turner, J. R., and Wiedensohler, A.: Methodology for high -quality mobile measurement with focus on black carbon and particle mass concentrations, Atmos. Meas. Tech., 12, 4697 -4712, 10.5194/amt -12-4697 -2019, 2019." 33 357 W4378378413.pdf 22 5 separator 0.9039073 ¶ 359 361 W4378378413.pdf 22 6 bibliography 0.99784774 Apte, J. S., Messier, K. P., Gani, S., Brauer, M., Kirchstetter, T. W., Lunden, M. M., Marshall, J. D., Portier, C. J., Verme ulen, R. C. 525 361 503 W4378378413.pdf 22 7 separator 0.8869805 ¶ 504 506 W4378378413.pdf 22 8 bibliography 0.9979754 "H., and Hamburg, S. P.: High -Resolution Air Pollution Mapping with Google Street View Cars: Exploiting Big Data, Environmental Science & Technology, 51, 6999 -7008, 10.1021/acs.est.7b00891, 2017." 506 706 W4378378413.pdf 22 9 separator 0.92894304 ¶ 708 710 W4378378413.pdf 22 10 bibliography 0.99406934 "Bauerová, P., Šindelářová, A., Rychlík, Š., Novák, Z., and Keder, J.: Low -Cost Air Quality Sensors: One -Year Field Comparative Measurement of Different Gas Sensors and Partic le Counters with Reference Monitors at Tušimice Observatory, Atmosphere, 11, 492, 2020. 530" 710 986 W4378378413.pdf 22 11 separator 0.96141064 ¶ 987 989 W4378378413.pdf 22 12 bibliography 0.99721855 "Brantley, H. L., Hagler, G. S. W., Kimbrough, E. S., Williams, R. W., Mukerjee, S., and Neas, L. M.: Mobile air monitoring da ta- processing strategies and effects on spa tial air pollution trends, Atmos. Meas. Tech., 7, 2169 -2183, 10.5194/amt -7-2169 -2014, 2014." 989 1260 W4378378413.pdf 22 13 separator 0.9372568 ¶ 1262 1264 W4378378413.pdf 22 14 bibliography 0.99815476 "Castell, N., Dauge, F. R., Schneider, P., Vogt, M., Lerner, U., Fishbain, B., Broday, D., and Bartonova, A.: Can commercial l ow-cost sensor platforms contribute to air quality monitoring and exposure estimates?, Environment International, 99, 293 -302, 535" 1264 1525 W4378378413.pdf 22 15 separator 0.50970316 1526 1527 W4378378413.pdf 22 16 bibliography 0.97519976 ¶ https://doi.org/10.1016/j.envint.2016.12.007 , 2017. 1527 1581 W4378378413.pdf 22 17 separator 0.94990253 ¶ 1583 1585 W4378378413.pdf 22 18 bibliography 0.9979993 "Chambliss, S. E., Pinon, C. P. R., Messier, K. P., LaFranchi, B., Upperman, C. R., Lunden, M. M., Robinson, A. L., Marshall, J. D., and Apte, J. S.: Local - and regional -scale racial and ethnic disparities in air pollution determined by long -term mobile monitoring, Proceedings of the National Academy of Sci ences, 118, e2109249118, 10.1073/pnas.2109249118, 2021." 1585 1958 W4378378413.pdf 22 19 separator 0.96114284 ¶ 1960 1962 W4378378413.pdf 22 20 bibliography 0.99802834 "Clements, A. L., Griswold, W. G., RS, A., Johnston, J. E., Herting, M. M., Thorson, J., Collier -Oxandale, A., and Hannigan, M.: Low - 540 Cost Air Quality Monitoring Tools: From Research to Practice (A Work shop Summary), Sensors, 17, 2478, 2017." 1962 2213 W4378378413.pdf 22 21 separator 0.9599414 ¶ 2215 2217 W4378378413.pdf 22 22 bibliography 0.997951 "Collier -Oxandale, A., Feenstra, B., Papapostolou, V., Zhang, H., Kuang, M., Der Boghossian, B., and Polidori, A.: Field and laboratory performance evaluations of 28 gas -phase air quality sensors by the AQ -SPEC progra m, Atmospheric Environment, 220, 117092, https://doi.org/10.1016/j.atmosenv.2019.117092 , 2020." 2217 2539 W4378378413.pdf 22 23 separator 0.94206095 ¶ 2541 2543 W4378378413.pdf 22 24 bibliography 0.99802375 "Kebabian, P. L., Herndon, S. C., and Freedman, A.: Detection of Nitrogen Dioxide by Cavity Attenua ted Phase Shift Spectroscopy, 545 Analytical Chemistry, 77, 724 -728, 10.1021/ac048715y, 2005." 2543 2740 W4378378413.pdf 22 25 separator 0.9487351 ¶ 2742 2744 W4378378413.pdf 22 26 bibliography 0.9978844 "Li, Y., Yuan, Z., Chen, L. W. A., Pillarisetti, A., Yadav, V., Wu, M., Cui, H., and Zhao, C.: From air quality sensors to sen sor networks: Things we need to learn, Se nsors and Actuators B: Chemical, 351, 130958, https://doi.org/10.1016/j.snb.2021.130958 , 2022." 2744 3014 W4378378413.pdf 22 27 separator 0.9559938 ¶ 3016 3018 W4378378413.pdf 22 28 bibliography 0.9979679 "Long, R. W., Whitehill, A., Habel, A., Urbanski, S., Halliday, H., Colón, M., Kaushik, S., and Landis, M. S.: Comparison of ozone 550 measurement methods in biomass burning smoke: an evaluation under field and laboratory conditions, Atmos. Meas. Tech., 14, 1783 -1800, 10.5194/amt -14-1783 -2021, 2021." 3018 3327 W4378378413.pdf 22 29 separator 0.961022 ¶ 3329 3331 W4378378413.pdf 22 30 bibliography 0.99799186 "Masey, N., Gillespie, J., Ezani, E., Lin, C., Wu, H., Ferguson, N. S., Hamilton, S., Heal, M. R., and Beverland, I. J.: Temporal changes in field calibration relationships for Aeroqual S500 O3 and NO2 sensor -based monitors, Sensors and Actuators B: Chemical, 273, 1800 -1806, https://doi.org/10.1016/j.snb.2018.07.087 , 2018. 555" 3331 3670 W4378378413.pdf 22 31 separator 0.96288776 ¶ 3671 3673 W4378378413.pdf 22 32 bibliography 0.99784297 "Messier, K. P., Chambliss, S. E., Gani, S., Alvarez, R., Brauer, M., Choi, J. J., Hamburg, S. P., Kerckhoffs, J., LaFranchi, B., Lunden, M. M., Marshall, J. D., Portier, C. J., Roy, A., Szpiro, A. A., Vermeulen, R. C. H., and Apte, J. S.: Mapping Air Pollution with Google Street View Cars: Efficient Approaches with Mobile Monitoring and Land Use Regression, Environmental Science & Technology, 52, 12563 -12572, 10.1021/acs.est.8b03395, 2018." 3673 4128 W4378378413.pdf 22 33 separator 0.95720255 ¶ 4130 4132 W4378378413.pdf 22 34 bibliography 0.99797076 "Solom on, P. A., Vallano, D., Lunden, M., LaFranchi, B., Blanchard, C. L., and Shaw, S. L.: Mobile -platform measurement of air 560 pollutant concentrations in California: performance assessment, statistical methods for evaluating spatial variations, and sp atial representativeness, Atmos. Meas. Tech., 13, 3277 -3301, 10.5194/amt -13-3277 -2020, 2020." 4132 4492 W4378378413.pdf 22 35 separator 0.93195343 ¶ 4494 4496 W4378378413.pdf 22 36 bibliography 0.99757046 "Van Poppel, M., Peters, J., and Bleux, N.: Methodology for setup and data processing of mobile air quality measurements to as sess the spatial variability of concentrations i n urban environments, Environmental Pollution, 183, 224 -233, https://doi.org/10.1016/j.envpol.2013.02.020 , 2013. 565" 4496 4797 W4378378413.pdf 22 37 separator 0.9729694 ¶ 4798 4800 W4378378413.pdf 22 38 bibliography 0.99794227 "Wang, S., Ma, Y., Wang, Z., Wang, L., Chi, X., Ding, A., Yao, M., Li, Y., Li, Q., Wu, M., Zhang, L., Xiao, Y., and Zhang, Y.: Mobile monitoring of urban air quality at high spatial resolution by low -cost sensors: impacts of COVID -19 pandemic lockdown, Atmos. Chem. Phys., 21, 7199 -7215, 10.5194/acp -21-7199 -2021, 2021." 4800 5130 W4378378413.pdf 22 39 separator 0.96684396 ¶ 5132 5134 W4378378413.pdf 22 40 bibliography 0.99781317 "Weissert, L., Alber ti, K., Miles, E., Miskell, G., Feenstra, B., Henshaw, G. S., Papapostolou, V., Patel, H., Polidori, A., Salmond, J. A., and Williams, D. E.: Low -cost sensor networks and land -use regression: Interpolating nitrogen dioxide concentration at high 570 temporal an d spatial resolution in Southern California, Atmospheric Environment, 223, 117287, https://doi.org/10.1016/j.atmosenv.2020.117287 , 2020." 5134 5564 W4378378413.pdf 22 41 separator 0.9440933 ¶ 5566 5568 W4378378413.pdf 22 42 bibliography 0.99793935 "Whitehill, A. R., Lunden, M., Kaushik, S., and Solomon, P.: Uncertainty in collocated mobile measurements of air quality, Atmospheric Environment: X, 7, 100080, https://doi.org/10.1016/j.aeaoa.2020.100080 , 2020." 5568 5784 W4378378413.pdf 22 43 separator 0.9439975 ¶ 5786 5788 W4378378413.pdf 22 44 bibliography 0.9975175 "Wild, R. J., Dubé, W. P., Aikin, K. C., Eilerman, S. J., Neuman, J. A., Peischl, J., Ryerson, T. B., and Brown, S. S.: On -road 575 measurements of vehicle NO2/NOx emission ratios in Denver, Colorado, USA, Atmospheric Environment, 148, 182 -189, https://doi.org/10.1016/j.atmosenv.2016.10.039 , 2017. https://doi.org/10.5194/amt-2023-82" 5788 6132 W4378378413.pdf 22 45 separator 0.9107511 ¶ 6132 6134 W4378378413.pdf 22 46 paratext 0.967479 "Preprint. Discussion started: 2 May 2023 c Author(s) 2023. CC BY 4.0 License." 6134 6214 W4378378413.pdf 22 47 separator 0.99285364 ¶ 6214 6216 W4378378413.pdf 22 0 paratext 0.55386376 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 1 66 W4388880737.pdf 0 1 separator 0.3770028 68 69 W4388880737.pdf 0 2 paratext 0.39552432 ¶ 69 70 W4388880737.pdf 0 3 separator 0.75530213 "¶ ¶" 72 82 W4388880737.pdf 0 4 text 0.9987624 "Livistona is one of the genera of palm plants with a wide distribution area, ecologically diverse and of horticultural, economic and ecological importance. The Livistona genus is an important ornamental plant species for landscapes, and generally tolerates ¶ it as an indoor (Siregar, 2005). The purpose of this study was to determine the ecology of Serdang ( Livistona ¶ sp.) in Sekernan District and Mendahara Ulu District. This research was conducted in September - October 2021 based on the purposive sampling meth od. The results obtained are serdang ecology ( Livistona ¶ sp.) Sekernan and Mendahara Ulu subdistricts found 16 serdang individuals, the composition of vegetation at the study site for tree stadia population was only slightly in secondary forest cover found 8 species of trees, while for oil palm plantations/rubb er plantations there were 5 tree species, for the pole level most were found in oil palm plantations/rubber plantations with a total of 5 species while in secondary forest only 3 species, the sapling l evel was mostly found in oil palm plantations/rubber plantations because in rubber plantations the community allowed their gardens to be grown other than rubber. , the seedling rate was mostly found in oil palm/rubber plantations with a total of 29 species ¶ with 129 individuals compared to secondary forests. Ecological factors around the herbaceous plants for humidity range from 25 0 C – 31 0 C. The condition of the soil at the research site is sandy soil with a pH of 4.00 – ¶ 5.06. The slope of the medium - growing a rea is between 8% to 21%, which means that the herbaceous plant grows on the slope of the sloping to moderately steep area." 82 1870 W4388880737.pdf 0 5 separator 0.96846044 ¶ ¶ 1870 1876 W4388880737.pdf 0 6 title 0.8951978 Keywords 1876 1885 W4388880737.pdf 0 7 separator 0.57961285 ¶ 1885 1887 W4388880737.pdf 0 8 title 0.850585 : 1887 1889 W4388880737.pdf 0 9 separator 0.6744033 ¶ 1890 1892 W4388880737.pdf 0 10 title 0.8034933 Livistona, Vegetation, Ecological Factors 1892 1934 W4388880737.pdf 0 11 separator 0.830935 "¶ ¶" 1934 1944 W4388880737.pdf 0 12 text 0.9963072 "Livistona ¶ adalah salah satu dari marga tumbuhan palma yang wilayah penyebarannya lebar, ekologinya beragam dan bernilai penting secara hortikultura, ekonomi dan ekologi. Livistona adalah jenis tumbuhan hias yang penting untuk landskap, dan umumnya toleransi sebagai tanaman dalam ruang (Siregar, 2005). Tujuan penelitian ini mengetahui ekologi serdang ( Livistona sp .) di Kecamatan Sekernan dan Kecamatan Mendahara Ulu. Penelitian dilaksanakan pada bulan September - Oktober 2021 berdasarkan metode purposive sampling." 1944 2496 W4388880737.pdf 0 13 separator 0.9943256 ¶ 2497 2499 W4388880737.pdf 0 14 title 0.5580119 Hasil 2499 2505 W4388880737.pdf 0 15 text 0.9773368 "¶ penelitian ekologi serdang ( Livistona sp. ) Kecamatan Sekernan dan Kecamatan Mendahara Ulu ditemukan 16 individu serdang, Komposisi vegetasi dilokasi penelitian stadia pohon populasinya hanya sedikit pada tutupan hutan sekunder ditemukan 8 spesies pohon, sedangkan untuk kebun sawit/kebun karet ter dapat 5 spesies pohon, tingkat tiang paling banyak ditemukan di tutupan kebun sawit/kebun karet dengan jumlah 5 spesies sedangkan di hutan sekunder hanya 3 spesies, tingkat pancang banyak di temukan pada tutupan ke bun sawit/kebun karet karena pada kebun karet masyarakat membiarkan kebunnya ditumbuhan selain karet, tingkat semai banyak ditemukan di kebun sawit/kebun karet dengan jumlah 29 spesies dengan individu 129 dibandingkan hutan sekunder. Faktor ekologi di seki tar tumbuhan serdang kelembaban berkisar 25 0 C – 31 0 C. Keadaan tanah di lokasi penelitian yaitu tanah berpasir dengan pH 4.00 – ¶ 5.06. Kemiringan tempat tumbuh serdang antara 8% hingga 21% bearti tumbuhan serdang tumbuh di kemiringan tempat landai hingga agam curam." 2505 3619 W4388880737.pdf 0 16 separator 0.93910486 ¶ ¶ 3619 3625 W4388880737.pdf 0 17 title 0.849057 Kata kunci 3625 3636 W4388880737.pdf 0 18 separator 0.29413405 3636 3637 W4388880737.pdf 0 19 text 0.31880608 ¶ 3637 3638 W4388880737.pdf 0 20 table 0.7150132 ": Livistona, Vegetasi, Faktor Ekologi ¶ ¶ A bstract ¶ A bstrak ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶" 3638 3816 W4388880737.pdf 0 21 separator 0.34295687 3818 3819 W4388880737.pdf 0 22 table 0.37069055 ¶ 3819 3820 W4388880737.pdf 0 23 title 0.7064258 Serdang 3820 3828 W4388880737.pdf 0 24 table 0.40043044 ¶ 3828 3830 W4388880737.pdf 0 25 title 0.601302 ¶ (Livistona 3832 3846 W4388880737.pdf 0 26 table 0.33499512 ¶ 3846 3847 W4388880737.pdf 0 27 title 0.42557377 3849 3850 W4388880737.pdf 0 28 table 0.30549255 ¶ 3850 3851 W4388880737.pdf 0 29 title 0.5764157 "sp. )" 3851 3859 W4388880737.pdf 0 30 separator 0.43669838 ¶ 3860 3862 W4388880737.pdf 0 31 title 0.809687 "¶ Ecology ¶ in ¶ Sekernan ¶ Sub-Districd ¶ and ¶ KECAMATAN MENDAHARA ULU" 3864 3960 W4388880737.pdf 0 32 separator 0.8527702 ¶ 3960 3962 W4388880737.pdf 0 33 title 0.7120669 EKOLOGI 3962 3970 W4388880737.pdf 0 34 table 0.57826865 ¶ ¶ 3971 3977 W4388880737.pdf 0 35 title 0.54725593 SERDANG 3977 3985 W4388880737.pdf 0 36 table 0.62740254 ¶ ¶ 3986 3992 W4388880737.pdf 0 37 title 0.34962314 ( 3992 3994 W4388880737.pdf 0 38 table 0.54598045 ¶ 3994 3996 W4388880737.pdf 0 39 title 0.4455304 L 3996 3998 W4388880737.pdf 0 40 table 0.5755677 ¶ 3998 4000 W4388880737.pdf 0 41 title 0.51385224 ivistona 4000 4009 W4388880737.pdf 0 42 table 0.592551 ¶ ¶ 4009 4015 W4388880737.pdf 0 43 title 0.42246404 sp.) 4015 4020 W4388880737.pdf 0 44 table 0.57814395 ¶ ¶ 4021 4027 W4388880737.pdf 0 45 title 0.6241275 DI 4027 4030 W4388880737.pdf 0 46 table 0.51683104 ¶ ¶ 4031 4037 W4388880737.pdf 0 47 title 0.660447 KECAMATAN 4037 4047 W4388880737.pdf 0 48 table 0.52782446 ¶ ¶ 4048 4054 W4388880737.pdf 0 49 title 0.62789506 SEKERNAN 4054 4063 W4388880737.pdf 0 50 table 0.4159849 ¶ ¶ 4064 4070 W4388880737.pdf 0 51 title 0.53506 DAN 4070 4074 W4388880737.pdf 0 52 table 0.32724845 ¶ ¶ 4074 4080 W4388880737.pdf 0 53 separator 0.25597715 4082 4083 W4388880737.pdf 0 54 table 0.31822306 ¶ 4083 4084 W4388880737.pdf 0 55 separator 0.30428523 4086 4087 W4388880737.pdf 0 56 table 0.2395542 ¶ 4087 4088 W4388880737.pdf 0 57 separator 0.3366283 ¶ 4090 4095 W4388880737.pdf 0 58 paratext 0.30686453 ¶ 4095 4096 W4388880737.pdf 0 59 separator 0.50008184 4098 4099 W4388880737.pdf 0 60 paratext 0.36931166 ¶ 4099 4100 W4388880737.pdf 0 61 separator 0.6257082 ¶ 4102 4104 W4388880737.pdf 0 62 paratext 0.94816244 "Copyright © 2023, ¶ Nursanti ¶ et al. Submitted June 2023 Published July 2023 ¶ DOI : http://doi.org/10.22437/biospecies.v16i2.21623 E-ISSN : 2503-0426 ISSN : 19790902" 4104 4296 W4388880737.pdf 0 63 contact 0.9862964 "¶ * Email: ¶ adeadriadi@unja.ac.id KM15 Mendalo Darat, ¶ Jambi 36361 2 Prodi ¶ Biologi, ¶ Fakultas ¶ Sains ¶ dan ¶ Teknologi, ¶ Universitas ¶ Jambi, ¶ Jl. ¶ Jambi-Ma. ¶ Bulian ¶ Mendalo Darat, Jambi 36361 1 Prodi ¶ Kehutanan ¶ Fakultas ¶ Pertanian ¶ Universitas ¶ Jambi, ¶ Jl. ¶ Jambi-Ma. ¶ Bulian ¶ KM15 ¶ Nursanti 1 , Ade Adriadi 2* , Dwi Puji Astuti 1 Mendahara Ulu Sub-District" 4296 4794 W4388880737.pdf 0 64 paratext 0.9461074 "¶ Vol. 16 (2) : 34 ¶ – ¶ 45 , Juli 2023" 4794 4843 W4388880737.pdf 0 65 separator 0.95107055 ¶ 4843 4845 W4388880737.pdf 0 66 title 0.97769165 BIOSPECIES 4845 4856 W4388880737.pdf 0 0 paratext 0.9882932 245 Bakhtiniana , São Paulo, 18 (2): 226-247, abril/junho 2023. 0 63 W4381190842.pdf 19 1 separator 0.67766 65 66 W4381190842.pdf 19 2 paratext 0.957158 ¶ Todo conteúdo de Bakhtiniana . Revista de Estudos do Discurso está sob Licença Creati ve Commons CC - By 4.0 66 179 W4381190842.pdf 19 3 separator 0.9912615 ¶ 181 183 W4381190842.pdf 19 4 text 0.9985516 "valor artístico -formal da autoconsciência das personagens dosto ievskianas a partir das teorias dialógicas de Bakhtin . O processo de construção narrativa depende da capacidade de autoassimilação do narrador -autor, e é o que acontece de maneira bastante equilibrada nesse romance , em que uma voz orquestradora se sobrecar rega de responsabilidades heurísticas como uma ponte entre o ontem e o hoje: “Na loja, caminho sobre mortos. Sobre caveiras e vértebras, sobre fêmures e costelas, sobre perônios e falanges. Sobre sonhos e terrores. Não só eu, claro: quem sabe do mal que se esconde sob o assoalho das casas brasileiras?” (SCLIAR, 2009, p.176). Com a palavra alheia devidamente autoassimilada, nada é estranho a esse narrador que se aventurou por onde quis com sua imaginação , seguindo os hipotéticos passos de seu suposto ídolo, ou êmulo, Noel Nutels, figura histórica que ganha projeções heroicas e míticas por meio da captura de uma trajetória realista de um país que tentava se conhecer por dentro, por intermédio de seus sertanistas." 184 1269 W4381190842.pdf 19 5 separator 0.98895264 ¶ 1271 1273 W4381190842.pdf 19 6 text 0.999648 "Tanto em Cenas da vida minúscula , como em A Majestade do Xingu , temos trajetórias muito próximas em termos inventivos para retraduzir o trânsito do judeu no mundo e no Brasil, em particular tendo a Amazônia como pano de fundo para capturar as itinerâncias propostas de reconhecimento a partir dos res tolhos do espanto de tantas eras atravessadas . No primeiro romance estudado , a trajetória envereda pelo modo fantástico - maravilhoso, a fim de dar um contorno mais ambicioso de um percurso ancestral. No segundo romance, no entanto, as demarcações entre a re alidade e a fantasia estão bem palmilhadas e o processo de reconhecimento se dá entre as fronteiras estabelecidas pela própria sede de idealização do narrador -autor em relação à figura de um sertanista . Em termos de equilíbrio narrativo, percebo que A Maje stade do Xingu é muito mais interessante, mas ambos utilizam a Amazônia como um referente altamente moldável à sanha projetiva da problemática de afirmação histórica da questão judaica. A absorção da palavra alheia é o grande desafio das comunidades judaic as que se espalharam pelo mundo, por meio de diversas diásporas , o que as obriga a se reinventarem permanentemente a partir do olhar do outro por intermédio de uma voz que é sua e não é; ou de um lugar que é seu e não é . Esse sentido diaspórico encontra na Amazônia, por intermédio da ficção scliariana, um trampolim para toda forma de condições de uso de um imaginário indócil, ou de um imaginário que faz do desconhecido o mote para a afirma ção a partir do outro em si em permanente trânsito dialógico -monológi co, entre o" 1273 2950 W4381190842.pdf 19 0 paratext 0.9505296 "151 ¶ Vegetalika | https://doi.org/10.22146/veg. 77955" 0 63 W4381283137.pdf 5 1 separator 0.9955828 ¶ 64 66 W4381283137.pdf 5 2 text 0.90369767 "keragaan karakter produksi yang tidak berbeda dengan varietas pembanding pada ketiga karakter produksi tersebut (Tabel 2)." 67 196 W4381283137.pdf 5 3 separator 0.9478848 ¶ 198 200 W4381283137.pdf 5 4 text 0.9979011 "Karakter tinggi tanaman, jumlah daun per tanaman, jumlah daun segar saat panen dan seluruh komponen hasil mempengaruhi daya hasil tanaman jagung. Semakin tinggi karakter tersebut maka produksi jagung akan semakin meningkat (Sudika dan Soemeinaboedhy, 2020). Karakter diameter tongkol juga berpengaruh pada potensi produksi tanaman jagung. Semakin besar lingkar tongkol jagung maka bobot jagung dan berat biji akan semakin tinggi." 201 662 W4381283137.pdf 5 5 separator 0.77526355 ¶ 664 666 W4381283137.pdf 5 6 text 0.9986688 "Peningkatan berat biji diduga berhubungan erat dengan besarnya fotosintat yang disalurkan ke bagian tongkol (Dialista dan Noor, 2017)." 666 810 W4381283137.pdf 5 7 separator 0.9914905 ¶ 812 814 W4381283137.pdf 5 8 text 0.99504733 "Perla kuan kombinasi persilangan SB 1-3 x 7/5 1 -B dan 7/5 1 -B x KD 1 -1 memiliki tinggi tanaman dan diameter yang sama dengan varietas pembanding, namun pada karakter jumlah daun lebih banyak dibandingkan varietas pembanding. Hasil pada penelitian ini menunjukkan adanya penemuan yang berbeda dengan penelitian sebelumnya yang dilaporkan oleh Sudika dan Soemeinaboedhy (2020) dan Dialista dan Noor (2017). Ketiga karakter agronomi pada Tabel 1 tersebut tidak selalu berkorelasi positif dengan hasil produksi pada tanama n jagung. Faktor genotipe juga akan mempengaruhi tingkat produksi jagung manis. Hal ini dapat dilihat perlakuan kombinasi persilangan SB 1 -3 x 7/5 1 -B karakter produksi jagung manis yang sama dengan varietas pembanding, sedangkan perlakuan 7/5 1 -B x KD 1 -1 memiliki produksi jagung manis yang lebih rendah dibandingkan varietas pembanding." 815 1742 W4381283137.pdf 5 9 separator 0.99652326 ¶ 1744 1746 W4381283137.pdf 5 10 title 0.9574829 Anthesis Silking Interval (ASI) 1747 1780 W4381283137.pdf 5 11 separator 0.9605996 ¶ 1781 1783 W4381283137.pdf 5 12 text 0.9994758 "merupakan selisih antara waktu keluar bunga jantan dengan bunga betina. Setiap genotipe memiliki nilai ASI yang berbeda -beda. Pada perlak uan kombinasi persilangan ASI berkisar antara 2 -5 hari. Kombinasi perlakuan pada persilangan KD 1 -1 x 7/5 1 -B dan 7/5 1 -B x KD 1 -1 memiliki anthesis silking interval yang lebih besar dibandingkan perlakuan lainnya serta varietas pembanding. Perlakuan SB 1 -3 x 7/5 1 -B dan KD 1 -1 x SB 1 -3 memiliki anthesis silking interval kecil dan tidak berbeda nyata dengan perlakuan kombinasi persilangan 7/5 1-B x SB 1 -3, SB 1 -3 x KD 1 -1, dan varietas pembanding. Berdasarkan besaran umur panen perlakuan SB 1 -3 x 7/5 1 -B, KD 1 -1 x SB 1 -3, 7/5 1 -B x SB 1 -3, mempunyai umur panen yang sudah sama dengan varietas pembanding dan lebih cepat dibandingkan dengan tiga varietas lainnya. Ketiga varietas ini dan varietas pembanding memiliki umur panen yang genjah sekitar 70 hari. Pada variabel kadar kemanisan kombinasi persilangan SB 1 -3xKD 1 -1 memiliki rata -rata kadar kemanisan tinggi, tidak berbeda dengan varietas pembanding tetapi berbeda nyata dengan kombinasi persilangan KD 1 -1 x 7/5 1 -B(Tabel 3)." 1783 3020 W4381283137.pdf 5 13 separator 0.99139684 ¶ 3022 3024 W4381283137.pdf 5 14 text 0.9993421 "Pada tanaman jagung manis, karak ter yang diharapkan yaitu memiliki ASI kecil, umur panen cepat dan tingkat kemanisan yang tinggi. Pada perlakuan yang telah dilakukan, belum diperoleh kombinasi" 3025 3231 W4381283137.pdf 5 0 paratext 0.98951465 www.nature.com/scientificreports/2 0 34 W2599787879.pdf 1 1 separator 0.6820791 ¶ 34 36 W2599787879.pdf 1 2 paratext 0.9854291 Scientific RepoRtS | 7:44446 | DOI: 10.1038/srep44446 36 92 W2599787879.pdf 1 3 text 0.8353497 "genome assembly, whereas SNPs encompassed only 0.1%. All these underscored one significant source of genetic variations in germ cell genome—CNVs." 92 240 W2599787879.pdf 1 4 separator 0.97927773 ¶ 240 242 W2599787879.pdf 1 5 text 0.9995386 "Nowadays, it is widely shared that CNVs derived from a variety of ways during the formation of germ cells, such as DNA repair, replication errors, homologous recombination and chromosome separation errors. The gen - eration mechanism underlying these pathogenic CNVs has been studied extensively. Y et, the relationship between the genesis of these CNVs and their parental origin is still rarely known. Here, we launched a research on the parent-of-origin of de novo pathogenic CNVs found in Chinese patients with ID, DD and MCA. Through tracing the origins and genesis mechanisms of these CNVs and exploring the relative contributions of the genome stabil - ity of sperms and eggs to reproductive health, we hope to know more about genome structure variations in germ cells, enhance the effective differential diagnosis and prenatal diagnosis of genomic disorders and to provide the potential for the prevention and treatment of related diseases in the future." 242 1227 W2599787879.pdf 1 6 separator 0.99644816 ¶ 1227 1229 W2599787879.pdf 1 7 title 0.8096596 Results 1229 1237 W2599787879.pdf 1 8 separator 0.9957762 ¶ 1237 1239 W2599787879.pdf 1 9 text 0.9994659 "CNVs analysis and selection. Using SNP arrays and fluorescence in situ hybridization (FISH), 87 de novo suspicious pathogenic CNVs, including 69 deletions and 18 duplications, were identified in total in 87 unrelated patients with ID, DD and MCA. Ages of the probands span from 6 days to 34 years old. 65 patients carried CNVs overlapping with known chromosome syndromes like Wolf-Hirschhorn syndrome (WHS), Williams Beuren syn - drome (WBS) and Angelman/Prader Willi syndrome (AS/PWS). The remaining 22 patients carried rare de novo CNVs, such as deletion area 12p12.2-p12.1, 13q31.3-q32.1 and duplication area 9p24.3-p13.1, 10p15.3-p12.33." 1239 1899 W2599787879.pdf 1 10 separator 0.92071337 ¶ 1900 1902 W2599787879.pdf 1 11 text 0.9950902 "These regions have not been defined as a syndrome or disease-related area presently. The comprehensive informa - tion of 87 families is summarized in Supplementary Table S1 and the distribution of the CNVs on chromosome is illustrated in Fig. 1. The genome sequence coordinates based on GRCh37/hg19 assembly." 1902 2216 W2599787879.pdf 1 12 separator 0.9950087 ¶ 2216 2218 W2599787879.pdf 1 13 caption 0.9956117 "Figure 1. The distribution of 87 de novo CNVs on human chromosomes. Red bars represent deletions and blue bars represent duplications." 2218 2358 W2599787879.pdf 1 0 text 0.99764156 "redundant CNVs and CNVRs were less in galGal4 than in galGal3 because some galGal3 probe sequences could not be successfully converted to galGal4 probe se- quences. The number of CNVs and CNVRs reported were much fewer than those identified in mammals and humans." 0 273 W2050968414.pdf 4 1 separator 0.98683923 ¶ 273 275 W2050968414.pdf 4 2 text 0.99941146 "A comparison of the CNVRs in the five breeds indicated fewer CNVs and CNVRs in HD than in the other four chicken breeds in China, and CNVR-gains were more fre- quent than CNVR-losses (43 losses, 46 gains) in HD. This observation might reflect the fact that the HD is different from the other four local Chinese chicken breeds in origin, appearance, and production performance." 275 664 W2050968414.pdf 4 3 separator 0.97921443 ¶ 664 666 W2050968414.pdf 4 4 text 0.9996016 "The estimated cumulative CNVR length of 12.8 Mb (1.1% of the genome) was relatively long compared with that reported in recent studies [23,24,27,34], but lower expected when considering the sample size. Indeed, Crooijmans et al. [33] reported that CNVRs represented almost 5.4% of the chicken genome when samples from 64 animals were used for testing. This difference might reflect the limited CNV coverage of the platform used in the present study, resulting in a significant underestima- tion of real CNVs in chickens because a limited numberof individuals were surveyed. Thus, a greater number of birds should be examined to obtain a comprehensive picture of chicken CNVs. Furthermore, the incomplete- ness of the chicken genome assembly, suggests that a significant portion of the genome was not surveyed. The entire W chromosome was excluded from the analysis, and all probes assigned to ChrUn and other random chromosomes were also excluded." 666 1646 W2050968414.pdf 4 5 separator 0.98576725 ¶ 1646 1648 W2050968414.pdf 4 6 text 0.9977326 "To retrieve the information and annotation for the CNVRs based on the newest chicken genome sequence, distinct from previous studies on the gene contents of chicken CNVRs, we converted the location of the probes from galGal3 to galGal4 (2011 CGSC Gallus gallue-4.0/ galGal4) according to the probe sequence, and the gene contents were processed using the galGal4 genome. The gene content analysis detected 231 Ensembl genes among the 192 identified CNVRs. Among these, 167 protein-coding genes, such as PRLR andMTAP of chrZ, RHACD8 of chr4, SLMO2 ,TUBB1 ,a n d EDN3 of chr20, etc., were annotated and reported in previous studies [32,33]. Notably, two CNVRs (chr20: 11111788 –11248088 and chr20: 11654170 –11820202) were identified on chromosome 20. The distance between the loci was " 1648 2461 W2050968414.pdf 4 7 separator 0.9688844 ¶ 2461 2462 W2050968414.pdf 4 8 caption 0.991483 "Figure 3 Validation through qPCR in five test chicken breeds. Twenty-five samples from five breeds, Gushi chicken (GS), Lushi chicken (LS), Silkie chicken (SK), Xichuan Black-bone chicken (XC) and Houdan chicken (HD), were analyzed in qPCR for the six loci. The six loci are THRSP locus (A),PCCA locus (B),PRLR locus (C),SOCS2 locus (D),RHACD8 locus (E)and EDN3 locus (F), respectively. Each DNA sample was diluted to 10 ng/ μL, and the concentrations were verified using a spectrophotometer. Quantitative PCR analyses were processed using a standard curve method as previously described [32]." 2462 3064 W2050968414.pdf 4 9 paratext 0.98275495 Han et al. BMC Genomics 2014, 15:934 Page 5 of 10 3064 3113 W2050968414.pdf 4 10 separator 0.5289797 3113 3114 W2050968414.pdf 4 11 paratext 0.96188074 ¶ http://www.biomedcentral.com/1471-2164/15/934 3114 3161 W2050968414.pdf 4 0 separator 0.95650554 ¶ ¶ 1 6 W2803918666.pdf 3 1 paratext 0.6759148 EVS2 9 International Battery, Hybrid 6 43 W2803918666.pdf 3 2 title 0.5205246 and 43 47 W2803918666.pdf 3 3 paratext 0.540647 Fuel Cell Electric Vehicle Symposium 47 84 W2803918666.pdf 3 4 separator 0.9592828 ¶ 160 162 W2803918666.pdf 3 5 bibliography 0.9891604 "4 [9] Trope Yaacov, et.al., Construal Levels and Psychological Distance: Effects on Representation, Prediction, Evaluation, and Behavior, Journal of Consumer Psychology, 17(2) (2007)., 83 -95." 162 360 W2803918666.pdf 3 6 separator 0.9193857 ¶ 361 363 W2803918666.pdf 3 7 bibliography 0.9979647 [10] Trope, Y., et.al., Temporal Construal, Psychological Review, 110(3), (2003) 403- 421. 363 455 W2803918666.pdf 3 8 separator 0.8617154 ¶ 456 458 W2803918666.pdf 3 9 bibliography 0.9961918 "[11] Liberman, N., et.al., The role of feasibility and desirability considerations in near and distant future decisions: A test of temporal construal theory . Journal of Personality and Social Psychology 75, (1998) 5-18" 458 687 W2803918666.pdf 3 10 separator 0.9767065 ¶ 688 690 W2803918666.pdf 3 11 bibliography 0.99766076 "[12] Ona Egbue, Suzanna Long., Barriers to widespread adoption of electric vehicles: An analysis of consumer attitudes and perceptions , Energy Policy 48 (2012) , 717– 729." 690 869 W2803918666.pdf 3 12 separator 0.9796381 ¶ 871 873 W2803918666.pdf 3 13 bibliography 0.9793436 "[13] Yes, Gas Is Cheap. You Shou ld Still Buy a Hybrid, http://www.slate.com/articles/business/the_juice/2015/10/gas_is_cheap_and_americans_are_buying_le ss_efficient_cars_horrible_idea.html , accessed on 2016 -03-13" 873 1101 W2803918666.pdf 3 14 separator 0.95445377 ¶ 1102 1104 W2803918666.pdf 3 15 bibliography 0.9978356 [14] Lave, L.B., et.al, Are hybrid vehicles worth it? 38, 47 –50IEEE Spectrum, 2001. 1104 1190 W2803918666.pdf 3 16 separator 0.7201377 ¶ 1192 1194 W2803918666.pdf 3 17 bibliography 0.99741787 "[15] Ogden, J.M., et.al. Societal lifecycle costs of cars with alternative fuels/engines . Energy Policy 32, ( 2004) 7–27." 1194 1322 W2803918666.pdf 3 18 separator 0.9552089 ¶ 1324 1326 W2803918666.pdf 3 19 bibliography 0.9960354 [16] Government incentives, http://electricvehicles.caa.ca/government -incentives/, assessed on 2016- 03-01 1326 1435 W2803918666.pdf 3 20 separator 0.94857174 ¶ 1437 1439 W2803918666.pdf 3 21 bibliography 0.98462605 "[17] New Release, Ministry of Energy and Mines , https://archive.news.gov.bc.ca/releases/news_releases_2013 -2017/2015MEM0009- 000380.htm , assessed on 2016 -03-01." 1439 1612 W2803918666.pdf 3 22 separator 0.95716226 ¶ 1613 1615 W2803918666.pdf 3 23 bibliography 0.9954364 [18] Electric Vehicle Incentive Program Guide , Ministry of Transportation, Ontario, 2016 1615 1706 W2803918666.pdf 3 24 separator 0.73379534 ¶ 1708 1710 W2803918666.pdf 3 25 bibliography 0.9875864 "[19] Discover electric vehicles http://www.vehiculeselectriques.gouv.qc.ca/english/index.asp , assessed on 2016 -03-01." 1710 1834 W2803918666.pdf 3 26 separator 0.9905485 ¶ ¶ 1835 1841 W2803918666.pdf 3 27 title 0.6361441 Authors 1841 1849 W2803918666.pdf 3 28 separator 0.9897795 ¶ 1851 1853 W2803918666.pdf 3 29 text 0.9914832 "Xun Jiao is a master student working in Supply Chain Management Department in University of Manitoba. Currently, Xun is doing the research about sustainability. Specifically, he is studying c onsumers’ attitudes towards electric vehicles ’ adoption and promotion." 1853 2124 W2803918666.pdf 3 30 separator 0.9847178 ¶ ¶ 2126 2132 W2803918666.pdf 3 31 paratext 0.9565397 "World Electric Vehicle Journal Vol. 8 - ISSN 2032-6653 - ©2016 WEVA Page WEVJ8-0708" 2132 2218 W2803918666.pdf 3 0 paratext 0.97819793 722 Clinical Child and Family Psychology Review (2022) 25:720–736 0 65 W4284894257.pdf 2 1 separator 0.7952719 ¶ 65 67 W4284894257.pdf 2 2 paratext 0.98109436 1 3 67 71 W4284894257.pdf 2 3 separator 0.95288235 ¶ 71 73 W4284894257.pdf 2 4 bibliography 0.98205376 "et al., 2016; Vigerland et al., 2016; Wang et al., 2017; War - wick et al., 2017)." 73 158 W4284894257.pdf 2 5 text 0.43583584 Reviews 158 166 W4284894257.pdf 2 6 bibliography 0.55780125 166 167 W4284894257.pdf 2 7 text 0.99399316 "indicate significant, moderate- to-large effect-sized improvements in diagnostic remission and reductions in symptoms following empirically validated intervention. For example, the most recent Cochrane review reported that anxiety-focused cognitive behaviour therapy (CBT) was significantly more effective than waitlist/no treatment at reducing parent- and child-reported anxiety symptoms with moderate effect sizes of d = − 0.70 (95% CI − 0.90, − 0.51, Z = 7.01, p = < 0.001, N = 2137) and − 0.67 (95% CI [− 0.47, − 0.88], Z = 6.36, p = < 0.001, N = 2831), respectively (James et al., 2020). However, very few reviews have considered the efficacy of psychotherapy for anxiety based on functional changes." 167 910 W4284894257.pdf 2 8 separator 0.97039413 ¶ 910 912 W4284894257.pdf 2 9 text 0.99177504 "To date, only two meta-analyses have examined the impacts of psychotherapy for paediatric anxiety disorders and expanded the outcomes of interest beyond symptom/ diagnostic reduction to include measures of global func- tioning (James et al., 2020; Kreuze et al., 2018). As noted above, the Cochrane review by James et al. (2020) reported primarily on symptom and diagnostic improvement. How - ever, a secondary analysis evaluated the impact of CBT on improvements in clinician-reported global functioning compared with waitlist/no treatment controls and reported a large effect (d = 1.03 [0.68, 1.38], Z = 5.83, p < 0.001; N = 557). The only review to date that has specifically evalu- ated the impact of CBT for anxiety in children and ado- lescents according to measures of functioning reported a large effect size improvement when combining parent, child, and clinician reports (− 1.25 [− 1.59, − 0.90], Z = 7.10, p < 0.001; N = 1234) (Kreuze et al., 2018). The authors also evaluated the specific impact of CBT against controls on social functioning. This comparison comprised six studies and yielded a non-significant effect for CBT on social func- tioning as reported by the parent and/or the child combined (− 0.17 [− 0.45, 0.12], Z = 1.13, p = 0.26). Combining data from multiple reporters will likely increase heterogeneity and may miss potentially important information due to the commonly reported low-to-moderate inter-rater agreement between parents and children regarding anxiety symptoms and impairment (Choudhury et al., 2003 ; Comer & Kendall, 2004; Grills" 912 2563 W4284894257.pdf 2 10 bibliography 0.58493024 & 2563 2565 W4284894257.pdf 2 11 text 0.7847445 Ollendick, 2565 2576 W4284894257.pdf 2 12 bibliography 0.5523122 2002 2576 2581 W4284894257.pdf 2 13 text 0.6411472 ; Rapee 2581 2588 W4284894257.pdf 2 14 bibliography 0.7153325 et al., 1994 2588 2601 W4284894257.pdf 2 15 text 0.49754673 ; 2601 2602 W4284894257.pdf 2 16 bibliography 0.68111 "Popp et al., 2017" 2602 2623 W4284894257.pdf 2 17 text 0.74679863 ; Weems 2623 2630 W4284894257.pdf 2 18 bibliography 0.5179489 et al 2630 2636 W4284894257.pdf 2 19 text 0.98260754 "., 2011). According to De Los Reyes and Kazdin (2005) reporters disagree because of differing attributions for what causes the problem and differing per - spectives on whether or which problem requires treatment." 2636 2856 W4284894257.pdf 2 20 separator 0.8836124 ¶ 2857 2859 W4284894257.pdf 2 21 text 0.9988455 "Clinical researchers must reconcile these discrepancies in a way that gives due regard to all attributions and perspectives." 2859 2987 W4284894257.pdf 2 22 separator 0.98498434 ¶ 2987 2989 W4284894257.pdf 2 23 text 0.99960667 "Given the increased recognition of the importance of functioning in treatment of anxiety in recent years (Creswell et al., 2021), more studies are expected to have been published since the search conducted by Kreuze and colleagues in July 2016 (Kreuze et al., 2018). Furthermore, there have been comparatively few studies on the effects of treatments other than CBT variants; in fact, the two recently published reviews specifically excluded non-CBT trials (James et al., 2020; Kreuze et al., 2018). Given the potential for other psychotherapies to influence clinical practice and service development (Reynolds et al., 2012), the scope of evidence summaries should be expanded to encompass any psychological treatment for which there is evidence." 2989 3772 W4284894257.pdf 2 24 separator 0.97116786 ¶ 3772 3774 W4284894257.pdf 2 25 text 0.99965084 "It may be assumed that broad treatments for paediatric anxiety will result in functional gains, but the evidence base is currently limited in comparison to the substantial number of studies of psychotherapy for symptom/diagnos- tic outcomes. Due to the critical need to establish higher standards of evidence for anxiety-focused psychotherapies in this age group, it is important to examine the efficacy of subgroups that may moderate treatment impact estimates for functional outcomes. In particular, given the frequency with which treatments are delivered either in individual or group format and also the growing evidence base for online treatments, evaluating treatment moderation by format and intensity would be valuable. These subgroups have not been investigated at the meta-analytic level, leav - ing unanswered questions concerning the benefits of psy - chotherapy for functioning according to delivery format (individual vs group therapy) and the therapy intensity (traditional therapy vs low-intensity therapy). Symptom- based meta-analyses examining delivery format and even therapy intensity have often failed to demonstrate marked differences (e.g. Ewing et al., 2015; Ishikawa et al., 2007; James et al., 2020; Vigerland et al., 2016) but the same may not be true when evaluating functioning as an outcome." 3774 5162 W4284894257.pdf 2 26 separator 0.9837929 ¶ 5162 5164 W4284894257.pdf 2 27 text 0.99680114 "This meta-analysis therefore had three objectives. The first was to determine the overall efficacy of psychotherapy in enhancing (a) social functioning, (b) school-related func- tioning, and (c) global functioning in children and adoles - cents with anxiety disorders. It should be noted that there were insufficient studies evaluating other domains of func- tioning to allow meta-analysis. The second objective was to conduct subgroup analyses to examine potential moderators of these outcomes by delivery format and therapy intensity. " 5164 5724 W4284894257.pdf 2 28 separator 0.6176737 ¶ 5724 5725 W4284894257.pdf 2 29 text 0.9993236 "A final objective was to analyse and report outcomes sepa- rately based on the type of reporter used (child, parent, and clinician)." 5725 5863 W4284894257.pdf 2 30 separator 0.9957312 ¶ 5863 5865 W4284894257.pdf 2 31 text 0.585658 Method 5865 5872 W4284894257.pdf 2 32 separator 0.98741114 ¶ 5872 5874 W4284894257.pdf 2 33 text 0.995713 "The approach recommended by the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA; Page et al., 2021) was used to carry out this meta-analysis." 5874 6049 W4284894257.pdf 2 0 paratext 0.86928517 "involving animals were approved by the University of Auckland Animal Ethics Committee. Use of human cadaveric tissue was in accordance with the New Zealand Human Tissue Act 2008." 0 182 W2890708240.pdf 11 1 separator 0.96411014 ¶ 182 184 W2890708240.pdf 11 2 title 0.77082074 Consent for publication 184 208 W2890708240.pdf 11 3 separator 0.8967602 ¶ 208 210 W2890708240.pdf 11 4 paratext 0.64470834 Not applicable. 210 226 W2890708240.pdf 11 5 separator 0.98171234 ¶ 226 228 W2890708240.pdf 11 6 title 0.87643623 Competing interests 228 248 W2890708240.pdf 11 7 separator 0.9613641 ¶ 248 250 W2890708240.pdf 11 8 text 0.6041196 250 251 W2890708240.pdf 11 9 paratext 0.4980853 ND 251 253 W2890708240.pdf 11 10 text 0.894278 "has received consulting fees, speaker fees, or grants from Takeda, Teijin, Menarini, Pfizer, Ardea, AstraZeneca, Cymabay, Amgen, Abbvie, and Horizon outside the submitted work. The remaining authors declare that they have no competing interests." 253 505 W2890708240.pdf 11 11 separator 0.9791885 ¶ 505 507 W2890708240.pdf 11 12 title 0.9216124 Publisher ’sN o t e 507 527 W2890708240.pdf 11 13 separator 0.823825 ¶ 527 529 W2890708240.pdf 11 14 text 0.88145155 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 529 650 W2890708240.pdf 11 15 separator 0.9888648 ¶ 650 652 W2890708240.pdf 11 16 title 0.6412924 Author details 652 667 W2890708240.pdf 11 17 separator 0.97825295 ¶ 667 669 W2890708240.pdf 11 18 contact 0.9631508 "1Department of Medicine, Bone & Joint Research Group, University of Auckland, Auckland, New Zealand.2Department of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland.3Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand." 669 952 W2890708240.pdf 11 19 separator 0.6407671 ¶ 952 954 W2890708240.pdf 11 20 contact 0.96756417 "4Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland, New Zealand." 954 1089 W2890708240.pdf 11 21 separator 0.9593258 ¶ 1089 1091 W2890708240.pdf 11 22 paratext 0.9817808 Received: 15 March 2018 Accepted: 16 August 2018 1091 1140 W2890708240.pdf 11 23 separator 0.97426844 ¶ 1140 1142 W2890708240.pdf 11 24 title 0.5627744 References 1142 1153 W2890708240.pdf 11 25 separator 0.965742 ¶ 1153 1155 W2890708240.pdf 11 26 bibliography 0.99753064 "1. 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Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells. Am J Respir Cell Mol Biol. 2009;40(1):19 –30." 8234 8506 W2890708240.pdf 11 89 separator 0.9637677 ¶ 8506 8508 W2890708240.pdf 11 90 bibliography 0.9976618 "34. Inoue H, Takamori M, Shimoyama Y, Ishibashi H, Yamamoto S, Koshihara Y. Regulation by PGE(2) of the production of interleukin-6, macrophage colonyChhana et al. Arthritis Research & Therapy (2018) 20:208" 8508 8718 W2890708240.pdf 11 91 paratext 0.9201068 Page 12 of 13 8718 8732 W2890708240.pdf 11 0 paratext 0.9808859 254 C. Curceanu et al. 0 22 W2996545798.pdf 3 1 separator 0.99539447 ¶ 22 24 W2996545798.pdf 3 2 caption 0.98116755 "Fig.1. The SIDDHARTA-2 setup with the cryogenic target cell surrounded by the SDDs and the Veto-2 system within the vacuum chamber, while the Veto-1 device is surrounding the chamber on the outside." 24 227 W2996545798.pdf 3 3 separator 0.9932375 ¶ 227 229 W2996545798.pdf 3 4 text 0.65298766 kaonic deuterium were 229 251 W2996545798.pdf 3 0 math 0.8377182 "∂τ ∂U= ∑∂τt ∂UT t=1" 0 25 W4390271875.pdf 3 1 text 0.99272877 "In the LSTM neural network, the gradient calculation method is back -propagation over time. The formula of calculating the gradient of the loss function τ with parameters U, W and b is as follows:" 25 227 W4390271875.pdf 3 2 separator 0.98191845 ¶ 229 231 W4390271875.pdf 3 3 math 0.9461599 "Zk=Uhk−1+Wxk+b (10) ∂τ ∂U= ∑ ∑ δt,khk−1T t k=1T t=1 (11) ∂τ ∂W= ∑ ∑ δt,kxkT t k=1T t=1 (12) ∂τ ∂b= ∑ ∑ δt,kt k=1T t=1 (13) Zk=Uhk−1+Wxk+b∂τ ∂U= ∑ ∑ δt,khk−1T t k=1T t=1∂τ ∂W= ∑ ∑ δt,kxkT t k=1T t=1∂τ ∂b= ∑ ∑ δt,kt k=1T t=1" 232 512 W4390271875.pdf 3 4 text 0.9303868 "Where, Zk is the hidden layer’s net input at each time k (1≤k≤t); Error term δt,k is the derivative of the loss at time t with respect to the hidden layer’s net input Zk at time k [11]." 512 701 W4390271875.pdf 3 5 separator 0.9965024 ¶ 703 705 W4390271875.pdf 3 6 title 0.9901018 4. Empirical Research 705 727 W4390271875.pdf 3 7 separator 0.99135804 ¶ 729 731 W4390271875.pdf 3 8 title 0.9900753 4.1. Data Analysis 731 750 W4390271875.pdf 3 9 separator 0.9960855 ¶ 752 754 W4390271875.pdf 3 10 text 0.99598503 "The dataset used in this paper is time series of large amounts of financial data published on Kaggle. It is provided by Quandl , a platform for economic, financial and alternative datasets. It contains 10787 pieces of information on the daily gold pri ces featuring univariate time -series from Timestamp ('1970 -01-01 00:00:00') to Timestamp ('2020 -03-13 00:00:00')) and is a typical time series." 754 1162 W4390271875.pdf 3 11 separator 0.9458691 ¶ 1164 1166 W4390271875.pdf 3 12 text 0.9954903 "Set date column as an index. First of all, draw a chart of the gold prices over time, which can be seen in the f ollowing Figure 1 is that since 1970, the gold prices have been on the rise in general, and there are fluctuations. The price of gold reached a peak in 2012." 1166 1443 W4390271875.pdf 3 13 separator 0.98207825 ¶ ¶ 1445 1451 W4390271875.pdf 3 14 caption 0.9927247 Figure 1 : A chart of the gold prices over time . 1451 1501 W4390271875.pdf 3 15 separator 0.9963003 ¶ 1502 1504 W4390271875.pdf 3 16 title 0.9917795 4.1.1. Data Preprocessing 1504 1531 W4390271875.pdf 3 17 separator 0.99706256 ¶ 1533 1535 W4390271875.pdf 3 18 text 0.9959536 "In the experiment, choose column of prediction and normalize data. The rules of normalization are as follows:" 1535 1648 W4390271875.pdf 3 19 separator 0.95228666 ¶ 1650 1652 W4390271875.pdf 3 20 math 0.8874546 "x′=x−min (x) max (x)−min (x) (14) x′=x−min (x) max (x)−min (x)" 1653 1725 W4390271875.pdf 3 21 text 0.99360424 "In the paper, the MinMaxScaler class is used to normalize data. MinMaxScaler is a common way to scale data by linearly transforming the raw data into a range of minimum and" 1725 1901 W4390271875.pdf 3 22 separator 0.9883851 ¶ 1902 1904 W4390271875.pdf 3 23 paratext 0.9816203 "Proceedings of the 2nd International Conference on Financial Technology and Business Analysis DOI: 10.54254/2754-1169/61/20231255" 1904 2036 W4390271875.pdf 3 24 separator 0.7806605 ¶ 2036 2038 W4390271875.pdf 3 25 paratext 0.98305446 195 2038 2042 W4390271875.pdf 3 0 paratext 0.96315426 КЛАД НАЧАЛА РАННЕГО ЖЕЛЕЗНОГО ВЕКА У ПОСЕЛКА ОДОЕВСКИЕ ГОРЫ ... 363 0 75 W4225391089.pdf 7 1 separator 0.8951137 ¶ 75 77 W4225391089.pdf 7 2 bibliography 0.9953672 "ров, 2018, рис. 6: 12; Шульга , 2015, с. 240–241, рис. 11: 4–5; 12: 9 и др.; Кренке и др., 2011, с. 138, рис. 4А: 17–37 и т. д.)." 77 215 W4225391089.pdf 7 3 separator 0.99311936 ¶ 216 218 W4225391089.pdf 7 4 text 0.99180895 "Массивная умбоновидная бляха для древ - ностей АКИО также является довольно харак - терным изделием . Встречены как орнаменти - рованные экземпляры , так и без орнамента . По месту расположения в погребальных комплек - сах такие вещи определяются как нагрудные украшения (" 218 524 W4225391089.pdf 7 5 bibliography 0.97750694 "Патрушев , Халиков , 1982, с. 153, табл . 16: 6б; с. 154, табл . 17: 21; с. 164, табл . 27: 2з; с. 191, табл . 54: 12; с. 201, табл . 64: 2а; с. 248, табл . 111: 3в и др.; Халиков , 1977, с. 46)" 524 730 W4225391089.pdf 7 6 text 0.9939265 ". Однако существенным отличием бляхи из клада является наличие четырёх петель для привязи вместо одной у аналогов . Возмож - но, это свидетельствует об ином назначении предмета и его связи с конским снаряжением , также имеющим свои интересные особенно - сти." 730 1026 W4225391089.pdf 7 7 separator 0.9859768 ¶ 1026 1028 W4225391089.pdf 7 8 text 0.98197633 "Пронизи -распределители ремней – доволь - но редкая для АКИО категория древностей , а известные по назначению предметы довольно сильно отличаются от четырех изделий клада (" 1028 1223 W4225391089.pdf 7 9 bibliography 0.90164214 "Патрушев , Халиков , 1982, с. 181, табл . 44: 9б; с. 222, табл . 85: 3в; Чижевский , 2008, с. 153, рис. 32: 21, 26" 1223 1343 W4225391089.pdf 7 10 text 0.99161386 "). В качестве аналогий можно рассматривать некоторые типы пронизей ""раннескифского времени "" лесостепной зоны , обнаруженных в могильниках в верховьях р. Сулы (приток р. Днепр ) к юго-западу от места находки клада . Это тип пронизей усеченно - конической формы широких пропорций и тип с круглым и плоским щитком (Могилов , 2008, с. 67–68; рис. 127: 37, 45; 128: 19). Распро - странение таких пронизей на Суле датируется серединой VII–VI вв. до н. э. (Могилов , 2008, с. 67–68)." 1343 1882 W4225391089.pdf 7 11 separator 0.9914955 ¶ 1882 1884 W4225391089.pdf 7 12 text 0.9969808 "Заметно выделяются и стержневидные псалии из клада1, также относящиеся к довольно редкой категории находок в древно - стях АКИО . Довольно близкой аналогией им являются псалии из погребений и жертвенных комплексов I и II Мурзихинских могильников (Кузьминых , Чижевский , с. 116, рис. 6: 5–6, 13–14). Рассматриваемые псалии относятся" 1884 2259 W4225391089.pdf 7 13 separator 0.9944191 ¶ 2261 2263 W4225391089.pdf 7 14 caption 0.9903636 Рис. 7. «Скальпированные » площадки и подъемный материал в 2013–2014 гг. на поселении Тырново 14 (7). 2263 2370 W4225391089.pdf 7 15 separator 0.98331636 ¶ 2372 2374 W4225391089.pdf 7 16 caption 0.9952181 Площадка 1 – вид с юго-востока (а), площадка 2 – вид с юго-запада (б). 2374 2449 W4225391089.pdf 7 17 separator 0.9758128 ¶ 2450 2452 W4225391089.pdf 7 18 caption 0.99558157 Fig. 7. ‘Scalped’ sites and excavated material of 2013–2014 at the Tyrnovo 14 settlement (7). 2452 2546 W4225391089.pdf 7 19 separator 0.96877724 ¶ 2548 2550 W4225391089.pdf 7 20 caption 0.99507564 Site 1 – view from the southeast ( а), site 2 – view from the southwest ( б). 2550 2628 W4225391089.pdf 7 0 text 0.82085013 "fringes as ground colour. Hindwings small, whitish ochreous, discal spot absent, crosslines missing, fringes white. Underside of wings white, shining." 0 152 W4382796154.pdf 3 1 paratext 0.914992 A. SHIRV ANI 152 164 W4382796154.pdf 3 2 separator 0.7671995 ¶ 164 166 W4382796154.pdf 3 3 paratext 0.9815849 266 SHILAP Revta. lepid., 51 (202) junio 2023 166 212 W4382796154.pdf 3 4 caption 0.9881627 "Figure 1. Polymixis fakherehsabae Shirvani, sp. nov., male adults. A.Holotype, Iran, Kerman, Baft, Khabr National Park. B.Paratype, Iran, Kerman, Baft, Khabr National Park." 212 386 W4382796154.pdf 3 5 separator 0.9613795 ¶ 386 388 W4382796154.pdf 3 6 caption 0.54626423 B A 388 392 W4382796154.pdf 3 7 separator 0.99163395 ¶ 392 394 W4382796154.pdf 3 8 text 0.99840987 "Male genitalia (Figure 2): Uncus short, chevron-shaped, more, or less hairy. Tegumen short, penicular lobes semi globular, densely hairy. Vinculum short, V-shaped, juxta large, long, sub-deltoidal, sclerotized. Valva elongate, symmetrical, finely constricted at basal one-third. Sacculuslonger than wide, clavus as a short lobe. Harpe narrow, clasper very long, sclerotized, slightlyasymmetrical, with acute apical section and finely rounded triangular sub-apical process. Cucullussmall, rounded corona present. Aedeagus cylindrical, carina with small sclerotized ventro-lateralplate, longer and weaker dorso-lateral bar present. Vesica long, tubular, everted dorso-laterally, narrowbasally, with a fine basal cornutus. Distal two third broad, curved, medially with long and strongthorn-like cornutus, terminal section with small conical diverticulum covered with long setiformcornuti, median diverticulum (opposite to setiform cornuti) saccate, armed with terminal thorn-likecornutus." 394 1382 W4382796154.pdf 3 9 separator 0.9954052 ¶ 1382 1384 W4382796154.pdf 3 10 caption 0.9879489 "Figure 2. Polymixis fakherehsabae Shirvani, sp. nov., male genitalia. A.Armature. B.Aedeagus and everted vesica." 1384 1499 W4382796154.pdf 3 11 separator 0.99013174 ¶ 1499 1501 W4382796154.pdf 3 12 caption 0.49591684 B A 1501 1505 W4382796154.pdf 3 0 text 0.9900283 "inFig 4C to 4E , LSS induced p70S6K-Thr389 and S6RP-Ser235/236 expression in 5 minutes and this continued for 30 minutes, which was in accordance with the changes of raptor-Ser792." 0 182 W2279317549.pdf 6 1 separator 0.89213806 ¶ 182 184 W2279317549.pdf 6 2 text 0.9985731 "However, the expression of these three proteins began to drop when LSS applied for more than 30 minutes. As for mTORC2 pathway, LSS decreased rictor-Thr1135 and Akt-Ser473 phos-phorylation as time passed, it initiated after 5 minutes, and lasted for 120 minutes ( Fig 4F and 4G)." 184 468 W2279317549.pdf 6 3 separator 0.91158843 ¶ 468 470 W2279317549.pdf 6 4 text 0.99847025 "Taken together, we believed that within 30 minutes LSS led to endothelial inflammation and oxidative stress by activation of mTORC1/eNOS-Thr495 and inhibition of mTORC2/Akt" 470 645 W2279317549.pdf 6 5 separator 0.9902196 ¶ 645 647 W2279317549.pdf 6 6 caption 0.9960233 "Fig 3. Fluorescence microscopy of ROS-positive cells stained with DHE and DCF and nucleus stained with DAPI. (A, E) DHE-positive cells in red were counted for five different visual fields. (B, F) DCF-positive cells in bright green were counted for five different visual fields. (C, G) Bar diag ram showing quantitative data of DHE-positive cells. (D, H) Bar diagram showing quantitative data of DCF-positive cells. *p<0.05 versus LSS 0 minute, # p <0.05 versus LSS 30 or 120 minutes." 647 1137 W2279317549.pdf 6 7 separator 0.9505646 ¶ 1137 1139 W2279317549.pdf 6 8 paratext 0.9489067 doi:10.1371/journal.pone.0149694.g003 1139 1177 W2279317549.pdf 6 9 separator 0.96482134 ¶ 1177 1179 W2279317549.pdf 6 10 title 0.9226478 Ivabradine Prevents Endothelial Inflammation and Oxidative Stress 1179 1245 W2279317549.pdf 6 11 separator 0.74559283 ¶ 1245 1247 W2279317549.pdf 6 12 paratext 0.9724807 PLOS ONE | DOI:10.1371/journal.pone.0149694 February 18, 2016 7/1 5 1247 1315 W2279317549.pdf 6 0 text 0.999481 "and this would certainly lead to hysteresis. In the case of chan- nels 1 and 2, our theory suggests that the walls only make con- tact when the channel completely collapses. The absence of an interfacial “crack” may prevent the channel from smoothlyopening as pressure is removed, thus, limiting the flow of fluid back into the channel to restore electrical conductivity. In con- trast, the theory for channels 3 and 4 suggest that the area ofcontact between the channel walls increases smoothly during loading. This follows from the assumption that the channel sidewalls behave like elastic indenters that make unilateral contact with the channel base. While adhesion hysteresis is still possible even for smooth and reversible changes in elasticcontacts, we expect it to be much less pronounced than in the case of non-smooth contact between the same elastic bodies under similar external pressures." 0 921 W2083582064.pdf 3 1 separator 0.99146676 ¶ 921 923 W2083582064.pdf 3 2 text 0.99964297 "Lastly, the lower sensor signals in channels 3 and 4 may also be explained by the high surface tension of EGaIn, which may interfere with the ability of the fluid to wet to thesharp corners of the triangular geometries. Instead of being completely filled with EGaIn, channels 3 and 4 may contain voids in the corners of the channel, where, according to thetheory, we expect the change in area to be the greatest." 923 1342 W2083582064.pdf 3 3 separator 0.99387443 ¶ 1342 1344 W2083582064.pdf 3 4 text 0.99946535 "The main contribution of this work is to propose a simple but effective solution to improve sensor signals by changingthe physical geometry of embedded microchannels in liquid embedded hyperelastic pressure sensors. The simulation and experiments verified that the geometry of the channel cross-section significantly affects the linearity, sensitivity, and hys- teresis in pressure sensing, which are the critical factors to be considered in sensor design. However, the agreement betweentheory and experiment can be improved with more compre- hensive theoretical models that account for fluid viscosity, fluid-wall interactions, and viscoelasticity as well as fluidinjection techniques that ensure complete wetting of channel walls.We used acrylic as a mold material in our experiments due to its short machining time and cost effectiveness. How- ever, metal molds will further improve the surface quality resulting in higher sensor accuracy. Although sensor signalscan be post-processed using various types of filters, the approach proposed in this paper could reduce the cost of any necessary signal processing." 1344 2478 W2083582064.pdf 3 5 separator 0.98507816 ¶ 2478 2480 W2083582064.pdf 3 6 text 0.9362063 "This work was supported by the Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. The authors would like to thank DavidBreslau for his technical support." 2480 2680 W2083582064.pdf 3 7 separator 0.9946431 ¶ 2680 2682 W2083582064.pdf 3 8 bibliography 0.99797195 "1M. D. Dickey, R. C. Chiechi, R. J. Larsen, E. A. Weiss, D. A. Weitz, and G. M. Whitesides, Adv. Funct. Mater. 18, 1097–1104 (2008)." 2682 2817 W2083582064.pdf 3 9 separator 0.83223206 ¶ 2817 2819 W2083582064.pdf 3 10 bibliography 0.9980811 "2J.-H. So, J. Thelen, A. Qusba, G. J. Hayes, G. Lazzi, and M. D. Dickey, Adv. Funct. Mater. 19, 3632–3637 (2009)." 2819 2935 W2083582064.pdf 3 11 separator 0.92525405 ¶ 2935 2937 W2083582064.pdf 3 12 bibliography 0.99787086 "3S. Cheng, A. Rydberg, K. Hjort, and Z. Wu, Appl. Phys. Lett. 94, 144103 (2009)." 2937 3020 W2083582064.pdf 3 13 separator 0.8081534 ¶ 3020 3022 W2083582064.pdf 3 14 bibliography 0.99797046 4H.-J. Kim, C. Son, and B. Ziaie, Appl. Phys. Lett. 92, 011904 (2008). 3022 3093 W2083582064.pdf 3 15 separator 0.7046865 ¶ 3093 3095 W2083582064.pdf 3 16 bibliography 0.99790543 5S. Cheng and Z. Wu, Adv. Funct. Mater. 21, 2282–2290 (2011). 3095 3157 W2083582064.pdf 3 17 separator 0.93514234 ¶ 3157 3159 W2083582064.pdf 3 18 bibliography 0.99805075 "6Y.-L. Park, C. Majidi, R. Kramer, P. Berard, and R. J. Wood, J. Micro- mech. Microeng. 20, 125029 (2010)." 3159 3268 W2083582064.pdf 3 19 separator 0.8633311 ¶ 3268 3270 W2083582064.pdf 3 20 bibliography 0.9972891 "7Y.-L. Park, B. Chen, and R. J. Wood, IEEE Sens. J. 12, 2711–2718 (2012)." 3270 3346 W2083582064.pdf 3 21 separator 0.964802 ¶ 3346 3348 W2083582064.pdf 3 22 bibliography 0.9975244 "8R .D .P .W o n g ,J .D .P o s n e r ,a n dV .J .S a n t o s , Sens. Actuators, A 179, 62–69 (2012)." 3348 3451 W2083582064.pdf 3 23 separator 0.9587985 ¶ 3451 3453 W2083582064.pdf 3 24 bibliography 0.99765533 "9R. Kramer, C. Majidi, and R. J. Wood, in Proceedings of IEEE Interna- tional Conference on Robotics and Automation, Shanghai, China, 9-13 May 2011 (IEEE, 2011), pp. 1103–1107." 3453 3634 W2083582064.pdf 3 25 separator 0.9660101 ¶ 3634 3636 W2083582064.pdf 3 26 bibliography 0.99718124 "10C. Majidi, R. Kramer, and R. J. Wood, Smart Mater. Struct. 20, 105017 (2011)." 3636 3718 W2083582064.pdf 3 27 separator 0.9490882 ¶ 3718 3720 W2083582064.pdf 3 28 bibliography 0.9977599 "11R. Kramer, C. Majidi, R. Sahai, and R. J. Wood, in Proceedings of the IEEE/RSJ International Conference on Intelligent Robots and Systems, San Francisco, USA, 25-30 September 2011 (IEEE, 2011), pp. 1919–1926." 3720 3935 W2083582064.pdf 3 29 separator 0.9733074 ¶ 3935 3937 W2083582064.pdf 3 30 bibliography 0.9977567 "12Y.-L. Park, B. Chen, D. Young, L. Stirling, R. J. Wood, E. Goldfield, and R. Nagpal, in Proceedings of the IEEE/RSJ International Conference on Intelligent Robots and Systems, San Francisco, USA, 25-30 September 2011 (IEEE, 2011), pp. 4488–4495." 3937 4190 W2083582064.pdf 3 31 separator 0.96866167 ¶ 4190 4192 W2083582064.pdf 3 32 bibliography 0.997876 13I. N. Sneddon, Fourier Transforms , 1st ed. (McGraw-Hill, New York, 1951). 4192 4269 W2083582064.pdf 3 33 separator 0.712818 ¶ 4269 4271 W2083582064.pdf 3 34 bibliography 0.9980271 14K. R. Schull, Mater. Sci. Eng. R 36, 1–45 (2002).191904-4 Park et al. Appl. Phys. Lett. 101, 191904 (2012) 4271 4380 W2083582064.pdf 3 35 separator 0.9530022 ¶ 4380 4382 W2083582064.pdf 3 36 paratext 0.87565744 This article is copyrighted as indicated in the article. Reuse of AIP content is subject to the terms at: http://scitation.aip.org/termsconditions. Downloaded to IP: 128.2.20.8 4383 4561 W2083582064.pdf 3 37 separator 0.90079373 ¶ 4561 4563 W2083582064.pdf 3 38 paratext 0.97107863 On: Thu, 10 Dec 2015 22:44:35 4563 4593 W2083582064.pdf 3 0 paratext 0.95722824 156 S. SAMADIANFARD ET AL. 0 26 W2909932415.pdf 15 1 separator 0.9848737 ¶ 26 28 W2909932415.pdf 15 2 bibliography 0.99764806 "C h a i ,T . ,&D r a x l e r ,R .R .( 2014). Root mean square error (RMSE)ormeanabsoluteerror(MAE)?Argumentsagainst avoiding RMSE in the literature. Geoscientific Model Devel- opment,7,1247–1250." 28 230 W2909932415.pdf 15 3 separator 0.86417747 ¶ 230 232 W2909932415.pdf 15 4 bibliography 0.997844 "C h a u ,K .W .( 2017). Use of meta-heuristic techniques in rainfall-runoffmodelling. Water,9(3),1–6." 232 336 W2909932415.pdf 15 5 separator 0.9431547 ¶ 336 338 W2909932415.pdf 15 6 bibliography 0.9900199 "Chen,R.S.,Ersi,K.,Yang,J.P.,Lu,S.H.,&Zhao,W.Z.( 2004). Validation of five global radiation models with measured dailydatainChina. 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( 2001a).Gene expression programming in problem solving.6thOnlineworldConference.Onsoftcomputingin Industrialapplications(invitedtutorial)." 1524 1681 W2909932415.pdf 15 19 separator 0.8479661 ¶ 1681 1683 W2909932415.pdf 15 20 bibliography 0.99794066 "Ferreira, C. ( 2001b). Gene expression programming, A new adaptive algorithm for solving problems. Complex Systems , 13(2),87." 1683 1814 W2909932415.pdf 15 21 separator 0.91543216 ¶ 1814 1816 W2909932415.pdf 15 22 bibliography 0.99794257 "Ferreira,C.( 2006).Geneexpressionprogramming:Mathemat- ical modeling by an artificial intelligence. Berlin: Springer, p.478." 1816 1945 W2909932415.pdf 15 23 separator 0.9649197 ¶ 1945 1947 W2909932415.pdf 15 24 bibliography 0.9978001 "Fotovatikhah, F., Herrera, M., Shamshirband, S., Chau, K. W., Aizollahzadeh Ardabili, A., & Piran, J. ( 2018). Survey of computationalintelligenceasbasistobigfloodmanagement:Challenges, research directions and future work. 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JournalofAtmospheric andSolar-TerrestrialPhysics ,146,215–227." 4036 4260 W2909932415.pdf 15 45 separator 0.9696671 ¶ 4260 4262 W2909932415.pdf 15 46 bibliography 0.99805033 Mesbah,M.,Soroush,E.,&RostampourKakroudi,M.( 2017). 4262 4314 W2909932415.pdf 15 47 separator 0.7206062 ¶ 4314 4316 W2909932415.pdf 15 48 bibliography 0.99301654 "Predictingphysicalproperties(viscosity,density,andrefrac- tive index) of ternary systems containing 1-octyl-3-methyl- imidazolium bis (trifluoromethylsulfonyl) imide, esters andalcohols at 298.15K and atmospheric pressure, using rigor- ous classification techniques. Journal of Molecular Liquids , 225,778–787." 4316 4637 W2909932415.pdf 15 49 separator 0.9800363 ¶ 4637 4639 W2909932415.pdf 15 50 bibliography 0.99787194 "Ming,T.,De_Richter,R.,Liu,W.,&Caillol,S.( 2014).Fighting global warming by climate engineering: Is the earth radia- tion management and the solar radiation management anyoption for fighting climate change? Renewable and Sustain- able Energy Reviews ,31,792–834." 4639 4907 W2909932415.pdf 15 51 separator 0.9770632 ¶ 4907 4909 W2909932415.pdf 15 52 bibliography 0.99286926 "Moazenzadeh,R.,Mohammadi,B.,Shamshirband,S.,&Chau, K. W. (2018). Coupling a firefly algorithm with support vector regression to predict evaporation in northern Iran. Engineering Applications of Computational Fluid Mechanics , 12(1),584–597." 4909 5158 W2909932415.pdf 15 53 separator 0.9695394 ¶ 5158 5160 W2909932415.pdf 15 54 bibliography 0.9975227 "Mohammadi, K., Shamshirband, S., Anisi, M. H., Alam, K. A., & Petkovic, D. ( 2015). Support vector regression based prediction of global solar radiation on a horizontal surface. EnergyConversionandManagement ,91,433–441." 5160 5387 W2909932415.pdf 15 55 separator 0.9725797 ¶ 5387 5389 W2909932415.pdf 15 56 bibliography 0.99789333 "Mostafavi,E.S.,SaeidiRamiyani,S.,Sarvar,R.,IzadiMoud,H., &M o usa vi,S.M.( 2013).Ah yb ridco m p u ta tio nala p p r oach to estimate solar global radiation: An empirical evidencefromIran. Energy,49,204–210." 5389 5601 W2909932415.pdf 15 57 separator 0.97003585 ¶ 5601 5603 W2909932415.pdf 15 58 bibliography 0.99798256 "Mousavi, S. M., Mostafavi, E. S., Jaafari, A., Jaafari, A., & Hos- seinpour, F. ( 2015). Using measured daily meteorological parameterstopredictdailysolarradiation. Measurement ,76, 148–155." 5603 5800 W2909932415.pdf 15 59 separator 0.96524847 ¶ 5800 5802 W2909932415.pdf 15 60 bibliography 0.9979595 "Olatomiwa, L., Mekhilef, S., Shamshirband, S., & Petković, D. (2015). Adaptive neuro-fuzzy approach for solar radia- tionpredictioninNigeria. RenewableandSustainableEnergy Reviews,51,1784–1791." 5802 6002 W2909932415.pdf 15 61 separator 0.96593016 ¶ 6002 6004 W2909932415.pdf 15 62 bibliography 0.9977829 "O z g o r e n ,M . ,B i l g i l i ,M . ,&S a h i n ,B .( 2012). Estimation of global solar radiation using ANN over Turkey. Expert Sys- temswithApplications ,39,5043–5051." 6004 6180 W2909932415.pdf 15 63 separator 0.96603477 ¶ 6180 6182 W2909932415.pdf 15 64 bibliography 0.99771214 "Piri, J., & Kisi, O. ( 2015). Modelling solar radiation reached to the earth using ANFIS, NNARX, and empirical mod- els (Case studies: Zahedan and Bojnurd stations). Journal ofAtmosphericandSolar-TerrestrialPhysics ,123,39–47." 6182 6415 W2909932415.pdf 15 65 separator 0.9756049 ¶ 6415 6417 W2909932415.pdf 15 66 bibliography 0.9977728 "Piri,J.,Shamshirband,S.,Petkovic,D.,Tong,C.W.,&Rehman, M.H.(2015). Prediction of the solar radiation on the Earth" 6417 6533 W2909932415.pdf 15 0 paratext 0.9893101 Crystals 2022 ,12, 100 14 of 14 0 31 W4206098122.pdf 13 1 separator 0.9935696 ¶ 31 33 W4206098122.pdf 13 2 bibliography 0.987591 "23. Turkmen, H.S.; Miller, M.P .; Dawson, P .R.; Moosbrugger, J.C. A Slip-Based Model for Strength Evolution During Cyclic Loading. J. Eng. Mater. Technol. 2004 ,126, 329–338. [CrossRef]" 33 222 W4206098122.pdf 13 3 separator 0.96878016 ¶ 222 224 W4206098122.pdf 13 4 bibliography 0.9865819 "24. Lin, R.C.; Betten, J.; Brocks, W. Modeling of finite strain viscoplasticity based on the logarithmic corotational description. Arch. Appl. Mech. 2006 ,75, 693–708. [CrossRef]" 224 404 W4206098122.pdf 13 0 caption 0.99363595 Supplementary Figure 7. Effects of Cryptotanshinone (CPT), a STAT3 Y705-specific inhibitor on VM tube formation. A, Dose-dependent response of CPT on VM tube formation demonstrates inhibition of VM tube formation with increasing CPT doses. B, Quantification of VM tube formation of CPT-treated cells depicts reduced mesh number with increasing doses of CPT. C, Western blot analysis from samples of cells treated with increasing doses of CPT verifies inhibition of p-STAT3 at the Y705 phosphorylation site.+ Cryptotanshinone (CPT) STAT3 Y705-specific inhibitor 0 561 W4392658856.pdf 0 1 separator 0.9858531 ¶ 561 563 W4392658856.pdf 0 2 table 0.89726585 "Media CPT 5 μM CPT 10 μM Media CPT 5 μM CPT 10 μM020406080Nb MeshesMeshes ✱✱✱✱✱β-Actin42kD p-STAT375 kDMedia5 μM10μM+ CPTSTAT375 kD A BCMediaCPT 5 μMCPT 10 μM" 563 736 W4392658856.pdf 0 3 separator 0.99284756 ¶ 736 738 W4392658856.pdf 0 4 paratext 0.72824436 8 738 740 W4392658856.pdf 0 0 text 0.9963294 "cDNAs, labeling these by fluorophores and measuring the fluorescence intensities Im(t)emitted when they are hybridized to their complementary sequence attached to a microarray. Theseintensities are often given relative to a reference intensity I m R, which depends on the RNA but not on the time, and is measured froman unperturbed sample or a mixture of several samples. As themeasures come from different hybridizations, they must benormalized to correct for different effects including the unequal quantities of starting RNA, differences in labeling or detection efficiencies between the fluorescent dyes used, and systematicbiases in the measured expression levels [1–2]. The geneexpression profiles ~XX m(t)we consider here are defined as a function of the normalized intensities ~IIas:" 0 809 W1968903636.pdf 1 1 math 0.90951645 "¶ ~XXm(t)~~IIm(t)o r ~XXm(t)~~IIm(t) ~IIm R, ð1Þ" 809 862 W1968903636.pdf 1 2 separator 0.7508079 ¶ 862 864 W1968903636.pdf 1 3 text 0.9980006 "depending on the available data. We made here the common assumption that the RNA concentrations and the normalizedfluorescence intensities are proportional [3]. In what follows, theindex mwill refer indistinguishably to the RNA or the gene from which it is transcribed." 864 1138 W1968903636.pdf 1 4 separator 0.996591 ¶ 1138 1140 W1968903636.pdf 1 5 title 0.98710066 1.b Development of multicellular eukaryotes. 1140 1185 W1968903636.pdf 1 6 text 0.58043563 DNA 1185 1189 W1968903636.pdf 1 7 separator 0.73934275 ¶ 1189 1191 W1968903636.pdf 1 8 text 0.9963533 "microarray time series that monitor the different developmentalstages of multicellular eukaryotes and possess a sufficient numberof time points per stage are available for the vinegar fly Drosophila melanogaster , the urochordate Ciona intestinalis , the silkworm Bombyx moriand the mouse Mus musculus ." 1191 1499 W1968903636.pdf 1 9 separator 0.9806185 ¶ 1499 1501 W1968903636.pdf 1 10 text 0.9994558 "The Drosophila melanogaster DNA microarray time series [4] yields the expression levels of 4,028 genes across all four developmentalphases. Among the 67 time points, 31 are in the embryonic phase(covering 24 hours; the first 14 points are taken every half hour,and the last 17, every hour; the measuring period is equal to onehour, so that the former 14 measures overlap), 10 are in the larvalphase (spanning 81 hours in approximately 9 hour intervals), 18 inthe pupal phase (96 hours; 7 points every 2 hours, 3 points every 4 hours, 4 points every 6 hours, 2 points every 12 hours, one point after 8 hours, and one point after 16 hours), and 8 in the adultphase (30 days; 3 points every 2 days, 5 points every 5 days). Eachof these 67 samples was compared with a unique reference sample,consisting of a standard mixture of all samples of the series. Onlythe time series for male flies was considered in this paper.However, we also tested the female flies’ time series and obtainedvery similar results; the only differences lie in the adult phase. Asubset of 20 genes has been shown to be related to muscle development [5] and has been analyzed separately." 1501 2666 W1968903636.pdf 1 11 separator 0.99003685 ¶ 2666 2668 W1968903636.pdf 1 12 text 0.9995211 "The Ciona intestinalis DNA microarray time series [6] monitors the expression levels of 21,938 genes during the life cycle. Itcontains a total of 18 time points: 13 in the embryonic phase(17 hours), 1 in the larval phase, and 4 in the adult phase (4 months). All these expression levels were given relative to the same reference sample, corresponding to fertilization, except the latterfour points, which were each given relative to the previous point.To obtain meaningful profiles from these time points, we chose thefirst (fertilization) point as a reference, and multiplied theexpression levels at the four time points corresponding to theadult stage by the expression level of the previous point. We henceobtained a series of 18 time points with a unique reference sample." 2668 3451 W1968903636.pdf 1 13 separator 0.99099106 ¶ 3451 3453 W1968903636.pdf 1 14 text 0.9995754 "Two oligonucleotide-based DNA microarray time series of the mouse Mus musculus were considered. The first [7] reveals the expression pattern of 6,579 genes throughout the morphologicstages of lung development. It consists of a total of 11 time points,4 in the embryonic stage, 6 in the postnatal stage and 1 in the adultstage. The other time series [8] is focused on the mammary gland development. It monitors the expression of 12,488 genes over 18 time points, covering the virgin (3 points), pregnancy (7 points),lactation (3 points), and involution (5 points) stages. In theinvolution stage, the mammary gland undergoes complex processes of controlled apoptosis and tissue remodeling. The data used here corresponds to the average over 3 replicas." 3453 4216 W1968903636.pdf 1 15 separator 0.9819807 ¶ 4216 4218 W1968903636.pdf 1 16 text 0.99955827 "The silkworm Bombyx mori undergoes four distinctive main developmental stages, defined as embryo, larva, pupa, and adult moth, which are monitored by a DNA microarray series of 41–42time points [9]: 8 in the embryonic stage, 20 in the larval stage, 1in the prepupal stage, 10 in the pupal stage and 2 or 3 in the adult stage. Two replicas are analyzed and their average is taken." 4218 4604 W1968903636.pdf 1 17 separator 0.95452166 ¶ 4604 4606 W1968903636.pdf 1 18 text 0.9994354 "Female and male worms are considered separately, from the endof the larval stage. In contrast to all other series considered in thispaper, which measure mRNA concentrations, this series profiles miRNA expression. A total of 106 miRNAs are considered." 4606 4859 W1968903636.pdf 1 19 separator 0.8975843 ¶ 4859 4861 W1968903636.pdf 1 20 text 0.9992339 "Note that in several of the above listed series the cell samples were taken indistinguishably from any part of the organism and thus represent an average of the gene expression levels in the different tissues. In these cases, the measurements thus mix thedependencies of the expression levels on the organism’s develop-mental stage and on the cell’s host tissue." 4861 5230 W1968903636.pdf 1 21 separator 0.99695545 ¶ 5230 5232 W1968903636.pdf 1 22 title 0.9842754 1.c External perturbation of unicellular systems. 5232 5282 W1968903636.pdf 1 23 text 0.5580015 DNA 5282 5287 W1968903636.pdf 1 24 separator 0.6143133 ¶ 5287 5288 W1968903636.pdf 1 25 text 0.98900473 "microarray time series that monitor the response of gene expression levels upon perturbations have been considered for Escherichia coli ." 5288 5430 W1968903636.pdf 1 26 separator 0.7910963 ¶ 5430 5432 W1968903636.pdf 1 27 text 0.9995458 "A first kind of external perturbation is glucose–lactose diauxie, which is monitored in E. coli through a whole-genome DNA array time series [10]. A total of 4,289 genes and 17 time points wereconsidered, 3 before the diauxic lag, 10 during the growth onlactose and 4 after lactose exhaustion. There are thus two different phases of growth arrest, a transient one after depletion of glucose, during the diauxic lag, and another after depletion of lactose." 5432 5896 W1968903636.pdf 1 28 separator 0.9556718 ¶ 5896 5898 W1968903636.pdf 1 29 text 0.9995628 "Other kinds of environmental fluctuations, in particular cold, heat and oxidative stress, were studied by DNA microarray time series in Escherichia coli monitoring the expression profiles of 4,400 genes [11]. A total of 12 time points was considered for oxidativestress and 8 time points for cold and heat stress, covering the periods before stress, during growth arrest due to the stress, and during growth resumption. The last period corresponding to thestationary phase was considered after oxidative stress. For each ofthese perturbations 3 replicas were considered and their average was taken." 5898 6509 W1968903636.pdf 1 30 separator 0.99627453 ¶ 6509 6511 W1968903636.pdf 1 31 title 0.82212955 1.d Cell cycle. The gene expression levels along the cell cycle 6511 6575 W1968903636.pdf 1 32 separator 0.50219613 ¶ 6575 6577 W1968903636.pdf 1 33 text 0.99933064 "have been monitored in the yeast Saccharomyces cerevisiae by three DNA microarray time series, in which the cells were synchronizedby three independent methods: a factor arrest, elutriation, andarrest of a cdc15 temperature-sensitive mutant [12]. These series cover two to three successive cell cycles (16 time points for elutriation, 18 time points for a factor arrest, and 25 time pointsforcdc15 ), and profile more than 6,000 genes." 6577 7019 W1968903636.pdf 1 34 separator 0.9966258 ¶ 7019 7021 W1968903636.pdf 1 35 title 0.9915478 2. Detection of perturbation points in expression profiles 7021 7080 W1968903636.pdf 1 36 separator 0.9947442 ¶ 7080 7082 W1968903636.pdf 1 37 text 0.9988992 "The hypothesis we test here is that the limits of the developmental stages of higher eukaryotes appear in the gene expression profiles as regions where the expression levels undergosome kind of change. Similarly, the expression levels are alsoexpected to undergo modifications in response to stress or other external perturbations. The kind of change that is expected to occur in such particular regions is not obvious a priori . Expression levels generally vary over time (except in stationary phases), ofteneven in the absence of perturbations of any kind. We therefore do not search for changes in the expression levels of each geneDetection of Perturbation and Developmental Stages" 7082 7780 W1968903636.pdf 1 38 separator 0.97154486 ¶ 7780 7782 W1968903636.pdf 1 39 paratext 0.98503166 PLoS ONE | www.plosone.org 2 December 2011 | Volume 6 | Issue 12 | e27948 7782 7856 W1968903636.pdf 1 0 paratext 0.98961735 Fischer et al.6 0 15 W2989985442.pdf 5 1 separator 0.9516605 ¶ 15 17 W2989985442.pdf 5 2 title 0.9843248 Materials Research 17 36 W2989985442.pdf 5 3 separator 0.9954138 ¶ 36 38 W2989985442.pdf 5 4 text 0.9977533 "These different trends of the number of published articles by authors from the ten most productive countries are consistent with the already mentioned nearly invariant number of articles related to SANS published during the last two decades (Figure 1)." 38 303 W2989985442.pdf 5 5 separator 0.9965997 ¶ 303 305 W2989985442.pdf 5 6 title 0.99138325 4. Distribution Among Journals 305 336 W2989985442.pdf 5 7 separator 0.9963722 ¶ 336 338 W2989985442.pdf 5 8 text 0.9987761 "Another purpose of this work was to identify the journals in which the highest total number of articles related to SAS (either SAXS or SANS) were published." 338 501 W2989985442.pdf 5 9 separator 0.85124356 ¶ 502 504 W2989985442.pdf 5 10 text 0.9980343 "As shown in Figure 5a, the journals that published the highest numbers of articles related either to SAXS or SANS are, in decreasing order, Macromolecules, Polymer, Langmuir, Journal of Applied Crystallography, Journal of Polymer Science, Journal of Physical Chemistry, Journal of Biological Chemistry, Journal of Applied Polymer Science, Biophysical Journal and Journal of Colloids and Interfaces." 504 921 W2989985442.pdf 5 11 separator 0.99562246 ¶ 922 924 W2989985442.pdf 5 12 caption 0.9959048 "Figure 4. Historical evolution of the annual number of articles related to SANS published by authors from the ten most productive countries in 2018. (a) Countries for which the number of articles published in 2018 range from ~ 50 up to 150. (b) Countries for which the number of articles published in 2018 range from ~ 10 up to 40. Data in (a) and (b) were smoothed by five adjacent points averaging." 924 1331 W2989985442.pdf 5 13 separator 0.98403436 ¶ 1331 1333 W2989985442.pdf 5 14 caption 0.996362 "Figure 5. (a) Total number of articles related to SAXS or SANS published by different journals. (b) Historical evolution of the ratio of the number of articles related to SAXS or SANS with respect to the total number of articles published in Macromolecules." 1333 1594 W2989985442.pdf 5 15 separator 0.9909195 ¶ 1595 1597 W2989985442.pdf 5 16 text 0.9992757 "The straight line is a guide for the eye.Notice that among the mentioned 10 journals only three (J. Appl. Cryst. J.Phys. Chem. and J. Colloids and Int.) publish articles dealing with either soft and hard matter while the other seven journals only publish articles reporting applications to soft matter. This implies that SAS techniques are predominantly applied to structural characterizations of soft matter and to a lesser extent to studies of hard (inorganic) matter. Most of the articles dealing with soft matter report structural investigations of polymers in solid state and roughly about 10% to biological systems such as proteins in solution." 1597 2278 W2989985442.pdf 5 17 separator 0.97788584 ¶ 2278 2280 W2989985442.pdf 5 18 text 0.99897194 "The annual numbers of articles published in all journals listed in Figure 5a indicate a persistent increasing trend with different growth rates. Because of the fast growth of the total number of published articles reported in Figure 1, these increasing trends are a priori expected. Furthermore, we have determined the fractions of articles related to SAS with respect to the total number of articles published in each journal, which exhibit for most of them clearly increasing trends." 2280 2787 W2989985442.pdf 5 0 paratext 0.98759305 проект байкал 1(75) project baikalновости16 0 44 W4362698199.pdf 0 1 separator 0.9915524 ¶ 44 46 W4362698199.pdf 0 2 text 0.97770596 "по ул. Тимирязева, и видны купола Крестовоздвиженской церкви, ан- гел сидит на крыше дома с якорем в усадьбе В. П. Сукачева и внима- тельно читает список добрых дел... В иркутских зданиях происходят удивительные истории: в здании бывшего Русско-Азиатского банка – фантастический бал привидений, на арке между зданиями около ТЮЗа в вазе спрятана волшеб- ная книга, в трехэтажном доме на перекрестке улиц Ивановской и Большой в ювелирном магазине Кельмеера отважные сиамские коты отражают дерзкое ограбление..." 46 593 W4362698199.pdf 0 3 separator 0.57287204 ¶ 594 596 W4362698199.pdf 0 4 text 0.99398077 "Все это погружает ребенка в сказку, но не какую-то заморскую, далекую, а именно свою, разлитую в хорошо прочувствованном пространстве, в котором живет маленький чело- век, и это учит видеть необычное книги заключена в ее названии. В нем ощущается погружение в вол- шебную реальность, сотканную из конкретной исторической вязи." 596 945 W4362698199.pdf 0 5 separator 0.85264015 ¶ 946 948 W4362698199.pdf 0 6 text 0.99486244 "Писатель Юрий Баранов поместил своих героев в среду, плотно на- сыщенную городскими легендами, местными мифами, неожиданными ракурсами понимания обыденных вещей. Иркутск с его архитектурой, улицами, памятниками оживает и взаимодействует с ребятами и зверятами в самых разнообраз- ных ситуациях, которые отражены в цветных иллюстрациях: памят- ник Александру III склоняется и отдает шпору с сапога, гипсовые привратники спускаются с баре- льефов Русско-Азиатского банка и открывают двери, а императрица с медальона оживает и интригует против весны, грузовик несется" 948 1562 W4362698199.pdf 0 7 title 0.8514656 Губернаторская премия за книгу «Сказки улицы Большой» / 1562 1618 W4362698199.pdf 0 8 separator 0.63192654 ¶ 1618 1620 W4362698199.pdf 0 9 title 0.9623358 Governor’s Award for the design of the book “Tales of Bolshaya Street” 1620 1691 W4362698199.pdf 0 10 separator 0.99318016 ¶ 1691 1693 W4362698199.pdf 0 11 text 0.99665505 "Премия губернатора Иркутской области присуждается творче- ским работникам один раз в год за достижения в области культуры и искусства. В 2022 году этой наградой был отмечен краеведче- ский просветительский издатель- ский проект «Книга «Сказки улицы Большой»», над которым работали писатель Юрий Баранов и художни- ки Василий и Яна Лисицины." 1693 2060 W4362698199.pdf 0 12 separator 0.74248195 ¶ 2060 2062 W4362698199.pdf 0 13 text 0.998695 "Это издание – сборник сказок, действия которых происходят в Иркутске, причем сам город вы- ступает не как застывшее окруже- ние-фон, а как один из важнейших героев книги. Улица Большая – историческое название централь- ной улицы Иркутска, ныне – ул. Карла Маркса. По словам Платона, существует «правильность имен, присущая каждой вещи от приро- ды», и, возможно, природа этой текст" 2062 2473 W4362698199.pdf 0 14 separator 0.9867016 ¶ 2473 2475 W4362698199.pdf 0 15 contact 0.8795219 "Яна Лисицина Иркутский государственный университет / text Yana Lisitsina Irkutsk State University" 2475 2585 W4362698199.pdf 0 16 text 0.9654155 "В 2022 году премия губернатора Иркутской области творческим работникам за достижения в области культуры и искусства присуждена за краеведческий просветительский издательский проект «Книга «Сказки улицы Большой»» писателю Юрию Баранову и художникам Василию и Яне Лисициным. В статье раскрывается содержание этой книги, описывается концепция иллюстративного подхода." 2585 2964 W4362698199.pdf 0 17 separator 0.9900609 ¶ 2964 2966 W4362698199.pdf 0 18 bibliography 0.5539819 "Ключевые слова: Иркутская область; 2022 год; книга; иллюстрации; Ю. Баранов; В. Лисицин; Я. Лисицина." 2966 3071 W4362698199.pdf 0 19 separator 0.71210116 3071 3072 W4362698199.pdf 0 20 bibliography 0.5155396 / 3072 3073 W4362698199.pdf 0 21 text 0.85553545 "In 2022 the Irkutsk Region Governor’s Award for the creative work in the field of culture and art was given to the writer Yury Baranov and the artists Vasily Lisitsin and Yana Lisitsina for their regional educational publishing project “The Tales of Bolshaya Street”. The article reveals the content of the book and describes the concept of illustrative approach." 3073 3448 W4362698199.pdf 0 22 separator 0.99053544 ¶ 3448 3450 W4362698199.pdf 0 23 bibliography 0.47724292 Keywords: Ir 3450 3463 W4362698199.pdf 0 24 table 0.42405057 kutsk 3463 3468 W4362698199.pdf 0 25 bibliography 0.560794 region; 2022; book; illustrations; Y. Baranov; 3468 3515 W4362698199.pdf 0 26 table 0.45917627 V 3515 3517 W4362698199.pdf 0 27 bibliography 0.529646 ". Lisitsin; Ya. Lisitsi" 3517 3544 W4362698199.pdf 0 28 table 0.44170356 na 3544 3546 W4362698199.pdf 0 29 bibliography 0.47030056 . 3546 3547 W4362698199.pdf 0 30 separator 0.9956833 ¶ 3547 3549 W4362698199.pdf 0 0 text 0.99968755 "Consequently, an examination of the connection between the risk score and the Stage and TNM stage was carried out. Signi ficant differences existed between Stage 1&2 and Stage 3&4, T1&2 andT3&4, N1, N2 and N3, and M0 and M1, and poorer clinicalgrades were positively connected with greater risk ratings(Figures 7E –H). We also investigated the relationship between risk scores and age and gender, but no differences werediscovered ( Supplementary Figure S3 ). Following that, the IPS was used to validate our hypothesis by assessing how colon cancer patients responded to i mmunotherapy pairs. When the high-risk group did not respon d well to PD1 therapy and when CTLA4 was either positive or nega tive, there was a substantial difference between them and th e low-risk group. However, the other conditions were not statistically signi ficant ( Figures 7I –L)." 0 877 W4366824304.pdf 8 1 separator 0.98181117 ¶ 877 879 W4366824304.pdf 8 2 text 0.9996289 "Finally, we ran a drug sensitivity analysis in COAD, calculatedthe IC50 values for each drug, and selected four representativedrugs to display. The high-risk group responded better to Cisplatin and Metfor min, as seen in the figure. Imatinib and Paclitaxel both performed well in the low-risk group(Figures 7M –P)." 879 1197 W4366824304.pdf 8 3 title 0.8050056 "TME discrepancies between the high- and low-risk groups" 1197 1254 W4366824304.pdf 8 4 separator 0.99554884 ¶ 1254 1256 W4366824304.pdf 8 5 text 0.9992386 "First, we looked into the relationship between immune cell enrichment, seven genes, and risk scores in the model. Figure 8A illustrated the signi ficant correlation between the 7 genes and risk scores and immune cell enrichment. The risk score was mostlyrelated to Tregs, T cells with resting CD4 memory, activated NKcells, Macrophages M0, and rest ing dendritic cells. The two groups ’StromalScore and ESTIMATEScore, as determined by ESTIMATE analysis, signi ficantly differed from one another (Figure 8B ). After examining the risk ratings for ssGSEA enrichment, most immune cells displayed appreciableenrichment differences between the high and low risk groups(Figure 8C ). Finally, employing immune checkpoint and immune activation-related genes, researchers found that the majority ofimmunological activation-related genes were signi ficantly expressed differently between the high and low risk groups." 1256 2179 W4366824304.pdf 8 6 separator 0.8560082 ¶ 2179 2181 W4366824304.pdf 8 7 text 0.9996345 Unfortunately, the bulk of immune checkpoint genes weres i m i l a ri nb o t hg r o u p s( Figure 8D ). 2181 2285 W4366824304.pdf 8 8 separator 0.9962844 ¶ 2285 2287 W4366824304.pdf 8 9 caption 0.8432951 FIGURE 6 2287 2296 W4366824304.pdf 8 10 separator 0.9379219 ¶ 2296 2298 W4366824304.pdf 8 11 caption 0.9954643 "Evaluation of the risk model and the mutation difference between the two groups. (A,B) Analysis of risk scores and clinical information using univariate and multivariate Cox analyses. (C)Establishment of a nomogram for OS prediction. (D)Calibration curves for the 1-, 3-, and 5-years OS. (E)The ROC curves of the nomogram. (F,G) Waterfall diagram of mutations between high and low risk groups." 2298 2696 W4366824304.pdf 8 12 separator 0.98159516 ¶ 2696 2698 W4366824304.pdf 8 13 paratext 0.9768768 Frontiers in Genetics frontiersin.org 09Chen et al. 10.3389/fgene.2023.1149995 2698 2777 W4366824304.pdf 8 0 text 0.99718577 "measures was greater: away wilds to crops Shannon Hua = 0.21; near wilds to crops Shannon Hua = 0.12, and the single locus approach demonstrated that the Shannon Hua values were lower in near versus away populations, proximity and locus two-factor ANOVA, F = 25.12 p= 0.0002. Contemporary estimates of migration using the software program BayesAss yielded estimates of migration rates (range: 0.068% to 21%) that were relatively similar across popula-tions for Nantucket. The largest rate was the Cliff Rd population as an immigration source for the Polpis Rd population —both populations located away from crop fields ( S2 Table )." 0 642 W2508211520.pdf 7 1 separator 0.9837601 ¶ 642 644 W2508211520.pdf 7 2 text 0.9986756 "In the Olympic Peninsula (the seed production sampling area), fourteen nuclear SSRs (GSSR9 yielded unreliable amplification and was removed from further analyses) were poly- morphic in all populations, and unbiased multilocus gene diversity ranged from 0.42 in the" 644 913 W2508211520.pdf 7 3 separator 0.95517385 ¶ 913 915 W2508211520.pdf 7 4 caption 0.99637496 "Fig 1. Nantucket structure analysis. Results of structure analysis for K = 4 clusters (large pie charts) and chloroplast haplotypic diversity (small pie charts) for Nantucket Island." 915 1100 W2508211520.pdf 7 5 separator 0.8610314 ¶ 1100 1102 W2508211520.pdf 7 6 caption 0.86090297 doi:10.1371/journal.pone.0161971.g001 1102 1140 W2508211520.pdf 7 7 separator 0.9818648 ¶ 1140 1142 W2508211520.pdf 7 8 caption 0.71606064 Crop-Wild Gene Flow in Carrot 1142 1172 W2508211520.pdf 7 9 separator 0.91382915 ¶ 1172 1174 W2508211520.pdf 7 10 paratext 0.98044044 PLOS ONE | DOI:10.1371/journal.pone.0161971 September 7, 2016 8/1 9 1174 1242 W2508211520.pdf 7 0 title 0.98350006 ARE TITLES OF BOOKS COPYRIGHT? 0 30 W805613448.pdf 3 1 separator 0.9953712 ¶ 30 32 W805613448.pdf 3 2 text 0.9942107 "under the same title as that borne by the plaintiff's play. The court held: ""There is no evidence to show that defendants are publicly performing or representing complainant's 'dramatic composi- tion'. The right secured by the copyright act is the property in the literary composition, and not in the name or title given to it. In no case, so far as this court is advised, has protection been afforded by injunction under the copyright laws to the title alone, separate from the book or dramatic composition which it is used to designate. Whatever rights complainant may have to restrain appropriation by another of the title of his work, on general principles of equity, cannot be considered in this suit, which is a controversy between citizens of'the same state, and presents no federal question. Motion for injunction denied.""" 32 891 W805613448.pdf 3 3 separator 0.99013543 ¶ 891 893 W805613448.pdf 3 4 text 0.99941677 "In Glaser v. St. Elno Company7 it appeared that the copy- right of the novel entitled ""St. Elmo"" had expired in 19o8, but that before its expiration the author had authorized a dramatiza- tion of it to be made, and the copyright of the play was trans- ferred to the complainant. Shortly after the expiration of the copyright in the novel, the defendants brought out a dramatiza- tion of it under the same title, ""St. Elmo"", using the same plot and incidents, but neither making use of nor attempting to pass it off as complainant's play. The court held that when the novel fell into the public domain anyone was at liberty to dramatize it and to call his dramatization by the name of ""St. Elmo"", and refused to grant the injunction." 893 1648 W805613448.pdf 3 5 separator 0.9911235 ¶ 1648 1650 W805613448.pdf 3 6 text 0.99899274 "The latest case touching the question is Atlas Manufactur- ing Company v. Street & Smith,8 in which the complainants- appellees, Street & Smith, sought to restrain defendants from using in motion pictures or otherwise the name ""Nick Carter"", which complainants used as a general name to characterize detec- tive stories published by them. They based their property rights upon a registered trade mark and long-established trade name, but Judge Van Valkenburgh, in the course of his opinion, took occa- sion to inquire what the complainants' standing would be under the law of copyright with respect to the title, and used the follow- ing language:" 1650 2318 W805613448.pdf 3 7 separator 0.98241735 ¶ 2318 2320 W805613448.pdf 3 8 paratext 0.8838998 175 Fed. Rep. 276 (19(19). 2320 2347 W805613448.pdf 3 9 separator 0.8233628 ¶ 2347 2349 W805613448.pdf 3 10 paratext 0.86471575 m04 Fed. Rep. 398 (1913). 2349 2375 W805613448.pdf 3 11 separator 0.9969872 ¶ 2375 2377 W805613448.pdf 3 0 paratext 0.9606587 "ISSN: 2320 -5407 Int. J. Adv. Res. 7(7), 380-387 380 Journal Homepage: -www.journalijar.com ¶ ¶ Article DOI: 10.21474/IJAR01/ 9372 DOI URL: http://dx.doi.org/10.21474/IJAR01/ 9372" 0 292 W2967407273.pdf 0 1 separator 0.8781532 ¶ ¶ 294 300 W2967407273.pdf 0 2 title 0.9827617 RESEARCH ARTICLE 300 317 W2967407273.pdf 0 3 separator 0.7568177 ¶ ¶ 319 325 W2967407273.pdf 0 4 title 0.98571986 "A STUDY ON PREVALENCE OF MYTHS RELATED TO DENTAL HEALTH CARE AMONG THE POPULATION OF DISTRICT LUCKNOW ." 325 432 W2967407273.pdf 0 5 separator 0.987188 ¶ ¶ 433 439 W2967407273.pdf 0 6 contact 0.7569541 "Bhaskar Agarwal1, M K Agarwal2, Srishti Goel Agarwal 3, Manoj Pandey4, Kiran Tiwari5 and Sunit Kumar Jurel6." 439 551 W2967407273.pdf 0 7 separator 0.91343737 ¶ 552 554 W2967407273.pdf 0 8 contact 0.9906553 "1. Associate Professor, King Georg e’s Medical University, Lucknow. 2. Director, Dr. G. L. Gupta Institute of Public Health, University of Lucknow, Lucknow. 3. Director, Dental O3, Lucknow. 4. Assistant Professor, CB Gupta BSS Mahavidhayalaya, Lucknow. 5. Junior Engineer, Irrigation Department, Lucknow . 6. Associate Professor, King Georg e’s Medical University, Lucknow." 554 946 W2967407273.pdf 0 9 separator 0.8558699 ¶ 948 950 W2967407273.pdf 0 10 contact 0.91429317 ...................................................................................................................... 950 993 W2967407273.pdf 0 11 separator 0.8974711 ¶ 995 997 W2967407273.pdf 0 12 title 0.92851406 Manuscript Info 997 1014 W2967407273.pdf 0 13 table 0.2889567 Abstract 1016 1025 W2967407273.pdf 0 14 separator 0.4134817 ¶ 1027 1029 W2967407273.pdf 0 15 table 0.5576642 ......................... ............................................................... ......... 1029 1068 W2967407273.pdf 0 16 separator 0.9755615 ¶ 1070 1072 W2967407273.pdf 0 17 title 0.9239833 Manuscript History 1072 1091 W2967407273.pdf 0 18 separator 0.7774085 ¶ 1093 1095 W2967407273.pdf 0 19 paratext 0.5585888 "Received: 10 May 2019 Final Accepted: 12 June 2019 Published: July 2019" 1095 1175 W2967407273.pdf 0 20 separator 0.96510094 ¶ ¶ 1177 1183 W2967407273.pdf 0 21 title 0.43298241 Key words: 1183 1194 W2967407273.pdf 0 22 text 0.3964816 - 1194 1196 W2967407273.pdf 0 23 separator 0.4531917 1197 1198 W2967407273.pdf 0 24 text 0.41653788 ¶ Dental Myth 1198 1211 W2967407273.pdf 0 25 title 0.3792915 s 1211 1212 W2967407273.pdf 0 26 text 0.47220516 ", Public Health, Oral Health, Tobacco ." 1212 1254 W2967407273.pdf 0 27 separator 0.7278266 ¶ 1256 1258 W2967407273.pdf 0 28 table 0.31085682 1260 1261 W2967407273.pdf 0 29 math 0.31006294 ¶ 1261 1262 W2967407273.pdf 0 30 table 0.43047905 "¶ ¶ ¶ ¶ ¶ ¶ ¶ ¶ " 1264 1325 W2967407273.pdf 0 31 math 0.35078675 ¶ 1325 1326 W2967407273.pdf 0 32 table 0.31449607 1328 1329 W2967407273.pdf 0 33 math 0.3074597 ¶ ¶ 1329 1334 W2967407273.pdf 0 34 separator 0.74205834 "¶ ¶" 1336 1346 W2967407273.pdf 0 35 text 0.9983947 "Introduction: Today we believe that our society is very well aware of dentist, dentistry and its principles, but this crude traveling has its marks left in the minds of our society, and these exist in the form of myths." 1347 1577 W2967407273.pdf 0 36 separator 0.98187053 ¶ 1579 1581 W2967407273.pdf 0 37 text 0.989929 "Aim & Objectives: The aim of this study was t o find the prevalence of myths related to dental healthcare among the population of district Lucknow. It was done by finding the prevalence of myths related to dental healthcare among Urban and Rural population of district Lucknow and also comparing both the population." 1581 1912 W2967407273.pdf 0 38 separator 0.9848232 ¶ 1914 1916 W2967407273.pdf 0 39 text 0.9975121 "Material & Method: A total number of 687 individuals were interviewed out of which 408 were male and 279 were female, with a questionnaire containing a set of nine close -ended multiple choice questions, to facilitate data analysis avoid ambiguity." 1916 2175 W2967407273.pdf 0 40 separator 0.979374 ¶ 2177 2179 W2967407273.pdf 0 41 text 0.9995764 "Results: Among various myt hs associated with tooth extraction, the myth that tooth extraction ‘weakens eyesight’ was most common (71.2%) followed by ‘should not be done during rainy season’ (68.1%), ‘consumption of certain contraindicated items causes inflammation in gums’ (51.7%), ‘restriction on intake of certain food items’ (42.9%), ‘affecting hearing’ (13.5%), affecting brain (12.1%) and causing hair fall (13.1%). For each of the items related with tooth extraction a high proportion of respondents (2.9% to 18.9%) did not refle ct any opinion." 2179 2757 W2967407273.pdf 0 42 separator 0.96140504 ¶ 2759 2761 W2967407273.pdf 0 43 text 0.9994899 "Conclusion: The findings of present study showed that prevalence of dental myths was more common in underprivileged population, particularly women from lower socioeconomic strata. These findings indicated the need for a community initiative . Keeping in view the modifiable nature of myths, mass awareness campaigns using mass media, particularly audio -visual media are recommended apart from holding dental checkup camps in less privileged urban and rural areas." 2761 3244 W2967407273.pdf 0 44 separator 0.9401607 ¶ ¶ 3246 3252 W2967407273.pdf 0 45 paratext 0.9112626 Copy Right, IJA R, 201 9,. All rights reserved. 3269 3317 W2967407273.pdf 0 46 separator 0.5488423 ¶ 3319 3321 W2967407273.pdf 0 47 contact 0.9707947 "...................................................................................................................... Corresponding Author :-Sunit Kumar Jurel . Address: -Associate Professor, King George’s Medical University, Lucknow. ." 3321 3494 W2967407273.pdf 0 0 paratext 0.98731565 P- ISSN 1991 -8941 E -ISSN 2706 -6703 Journal of University of Anbar for Pure Science (JUAPS) Open Access 0 137 W4289297574.pdf 6 1 separator 0.5033961 191 192 W4289297574.pdf 6 2 paratext 0.94247776 ¶ 2021,15 ( 2 ) :1 -10 192 214 W4289297574.pdf 6 3 separator 0.79986715 ¶ 244 246 W4289297574.pdf 6 4 bibliography 0.9754727 "7 coronavirus infection as identified by temporal kinome analysis. Antimicrob Agents Chemother. 2015;59(2):1088 –99." 246 373 W4289297574.pdf 6 5 separator 0.92358017 ¶ 375 377 W4289297574.pdf 6 6 bibliography 0.9966317 "[38] Wadhwa P. MOLECULAR DOCKING STUDY OF NOVEL COVID -19 PROTEASE WITH CUR RENT CLINICAL MANAGEMENT AGENTS. Asian J Pharm Clin Res. 2020 Jul 1;37 –9." 377 538 W4289297574.pdf 6 7 separator 0.87040675 ¶ 540 542 W4289297574.pdf 6 8 bibliography 0.9976578 "[39] Chen Y, Lear T, Evankovich J, Larsen M, Lin B, Alfaras I, et al. A high throughput screen for TMPRSS2 expression identifies FDA -approved and clinically advanced compounds that can limit SARS - CoV -2 entry. 2020;" 542 774 W4289297574.pdf 6 9 separator 0.5723171 ¶ 776 778 W4289297574.pdf 6 10 bibliography 0.997826 "[40] Kainulainen MH, Bergeron E, Chatterjee P, Chapman AP, Lee J, Chida A, et al. High -throughput quantitation of SARS -CoV -2 antibodies in a single - dilution homogeneous assay. Sci Rep. 2021;11(1):1 – 9." 778 997 W4289297574.pdf 6 11 separator 0.7203057 ¶ 999 1001 W4289297574.pdf 6 12 bibliography 0.9979034 "[41] Li Q, Kang C. Progress in developing inhibitors of SARS -CoV -2 3C -like protease. 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Antiviral Res. 2014;101:122 –30." 1581 1797 W4289297574.pdf 6 19 separator 0.83619916 ¶ 1799 1801 W4289297574.pdf 6 20 bibliography 0.99790126 "[45] Xue X, Yu H, Yang H, Xue F, Wu Z, Shen W, et al. Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design. J Virol. 2008;82(5):2515 –27." 1801 2003 W4289297574.pdf 6 21 separator 0.84851545 ¶ 2005 2007 W4289297574.pdf 6 22 bibliography 0.9978717 "[46] Báez -Santos YM, John SES, Mesecar AD. The SARS -coronavirus papain -like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 2015;115:21 –38." 2007 2206 W4289297574.pdf 6 23 separator 0.8516813 ¶ 2208 2210 W4289297574.pdf 6 24 bibliography 0.9979856 "[47] Hilgenfeld R, Peiris M. From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses. Antiviral Res. 2013;100(1):286 –95." 2210 2364 W4289297574.pdf 6 25 separator 0.91339195 ¶ 2366 2368 W4289297574.pdf 6 26 bibliography 0.9978926 "[48] Kuo C -J, Liang P-H. Characterization and inhibition of the main protease of severe acute respiratory syndrome coronavirus. ChemBioEng Rev. 2015;2(2):118 –32." 2368 2542 W4289297574.pdf 6 27 separator 0.942249 ¶ 2544 2546 W4289297574.pdf 6 28 bibliography 0.9976503 "[49] Pillaiyar T, Manickam M, Namasivayam V, Hayashi Y, Jung S -H. An Overview of Severe Acute Respiratory Syndro me–Coronavirus (SARS -CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy. J Med Chem. 2016;59(14):6595 –628." 2546 2812 W4289297574.pdf 6 29 separator 0.93811524 ¶ 2814 2816 W4289297574.pdf 6 30 bibliography 0.9978779 "[50] Zhao Q, Weber E, Yang H. Recent developments on coronavirus main protease/3C like protease inhibitors. Recent Paten ts Anti -Infect Drug Disc. 2013;8(2):150 –6." 2816 2992 W4289297574.pdf 6 31 separator 0.924062 ¶ 2994 2996 W4289297574.pdf 6 32 bibliography 0.99805576 "[51] Kumar V, Shin JS, Shie J -J, Ku KB, Kim C, Go YY, et al. Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS -CoV) 3CLPro inhibitors. Antiviral Res. 2017;141:101 –6." 2996 3213 W4289297574.pdf 6 33 separator 0.9313929 ¶ 3215 3217 W4289297574.pdf 6 34 bibliography 0.9979544 "[52] Fischer A, Sellner M, Neranjan S, Lill MA, Smieško M. Inhibitors for Novel Coronavirus Protease Identified by Virtual Screening of 687 Million Compounds. 2020;" 3217 3392 W4289297574.pdf 6 35 separator 0.7357715 ¶ 3394 3396 W4289297574.pdf 6 36 bibliography 0.99770856 "[53] Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiol ogy of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020;395(10224):565 – 74." 3396 3622 W4289297574.pdf 6 37 separator 0.9488171 ¶ 3624 3626 W4289297574.pdf 6 38 bibliography 0.9979024 "[54] Chan JF -W, Yao Y, Yeung M -L, Deng W, Bao L, Jia L, et al. Treatment with lopinavir/ritonavir or interferon -β1b improves outcome o f MERS -CoV infection in a nonhuman primate model of common marmoset. J Infect Dis. 2015;212(12):1904 –13." 3626 3884 W4289297574.pdf 6 39 separator 0.97467107 ¶ 3886 3888 W4289297574.pdf 6 40 bibliography 0.99801636 "[55] Kim UJ, Won E -J, Kee S -J, Jung S -I, Jang H -C. Case report Combination therapy with lopinavir/ritonavir, ribavirin and interferon -α for Middle Ea st respiratory syndrome. Antivir Ther. 2016;21:455 –9." 3888 4108 W4289297574.pdf 6 41 separator 0.947754 ¶ 4110 4112 W4289297574.pdf 6 42 bibliography 0.9979397 "[56] Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, et al. A Trial of Lopinavir –Ritonavir in Adults Hospitalized with Severe Covid -19. N Engl J Med. 2020 May 7;382(19):1787 –99." 4112 4299 W4289297574.pdf 6 43 separator 0.9578807 ¶ 4301 4303 W4289297574.pdf 6 44 bibliography 0.9979329 "[57] Kirchdoerfer RN, Ward AB. Structure of the SARS - CoV nsp12 polymerase bound to nsp7 and nsp8 co - factors. Nat Commun. 2019;10(1):1 –9." 4303 4450 W4289297574.pdf 6 45 separator 0.95627826 ¶ 4452 4454 W4289297574.pdf 6 46 bibliography 0.99789315 "[58] Lee J -M, Cho J -B, Ahn H -C, Jung W, Jeong Y -J. A novel chemical compound for inhibition of SARS coronavirus helicase. J Microbiol Biotechnol. 2017;27:2070 –3." 4454 4631 W4289297574.pdf 6 47 separator 0.94282424 ¶ 4633 4635 W4289297574.pdf 6 48 bibliography 0.9937612 "[59] Al-Tawfiq JA, Al -Homoud AH, Memish ZA. Remdesivir as a possible therapeutic option for the COVID -19. Travel Med Infect Dis (Internet). 2020 Mar 5; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7 12 9391/" 4635 4876 W4289297574.pdf 6 49 separator 0.97521406 ¶ 4878 4880 W4289297574.pdf 6 50 bibliography 0.9977317 "[60] Zhu S, Guo X, Geary K, Zhang D. Emerging Therapeutic Strategies for COVID -19 patients. Discoveries. 2020;8(1)." 4880 5004 W4289297574.pdf 6 51 separator 0.94822204 ¶ 5006 5008 W4289297574.pdf 6 52 bibliography 0.9978891 "[61] Caly L, Druce JD, Catton MG, Jans DA, Wagstaff KM. The FDA -approved drug ivermectin inhibits the replication of SARS -CoV -2 in vitro. Antiviral Res. 2020 Jun 1;178:104787." 5008 5197 W4289297574.pdf 6 53 separator 0.9419751 ¶ 5199 5201 W4289297574.pdf 6 54 bibliography 0.99745643 "[62] Stockman LJ, Bellamy R, Garner P. SARS: Systematic Review of Treatment Effects. PLoS Med (Internet). 2006 Sep;3(9). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC156 4166/" 5201 5405 W4289297574.pdf 6 55 separator 0.9620911 ¶ 5407 5409 W4289297574.pdf 6 56 bibliography 0.9978509 "[63] Sulkowski MS. Anemia in the treatment of hepatitis C virus infection. Clin Infect Dis. 2003;37(Supplement_4):S315 –S322." 5409 5542 W4289297574.pdf 6 57 separator 0.95420754 ¶ 5544 5546 W4289297574.pdf 6 58 bibliography 0.99796486 "[64] Cobb AJ, Dell’Isola A, Abdulsattar BO, McLachlan MM, Neuman BW, Müller C, et al. Synthesis and antiviral activity of novel spirocyclic nucl eosides. New J Chem. 2018;42(22):18363 –80." 5546 5745 W4289297574.pdf 6 59 separator 0.95201695 ¶ 5747 5749 W4289297574.pdf 6 60 bibliography 0.99771535 "[65] Adedeji AO, Singh K, Kassim A, Coleman CM, Elliott R, Weiss SR, et al. Evaluation of SSYA10 - 001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses. Antimicrob" 5749 6009 W4289297574.pdf 6 0 text 0.9296499 "Out of the 28 species which had over 1000 individuals in trade, with >50% of wild caught individuals from countries for which they are not listed to be native in, these five have over 10,000 individuals purported to come from the wild from countries they are not listed as native in: Heterometrus spinifer (Ehrenberg 1828) (75,060), Grammostola spathulata (F. O. Pickard-Cambridge 1897) (notably a synonym of Grammostola rosea (Walckenaer 1837)) (72,096), Aphonopelma seemanni (F. O. Pickard- Cambridge 1897) (69,413), Haplopelma lividum (Smith 1996) (26,470) notably a nomenclature change from Cyriopagopus lividus (Smith 1996), Ephebopus murinus (Walckenaer 1837) (11,465). This also suggests that synonyms may be being used to misrepresent the origins of species in trade, for particularly popular species." 0 834 W4280516099.pdf 5 1 separator 0.99238575 ¶ 834 836 W4280516099.pdf 5 2 text 0.9986809 "We mapped richness and trade patterns for spiders and scorpions at species and genus level. For spiders, the digitisation of species ranges from the World Spider Catalog (WSC)18website yielded 134,187 connections between species and national areas for spiders alone. Richness peaked in China with 5139 species,followed by Brazil (3972), Australia (3906), and the United States(3880) also showing high richness (Supplementary Fig. S8).Despite smaller areas, Mexico (2466) and South Africa (2055) had very high richness. The highest percent of species in trade come from various islands and Cambodia, but parts of the Middle East,Uruguay and Suriname also show 10 –15% of species are traded (Supplementary Fig. S8). However, if genera with two species or fewer in trade are removed the percentage of species of trade in remaining groups is up to 60%, with high levels also found inBolivia and across much of North Africa, and still including113 species being traded from Brazil." 836 1831 W4280516099.pdf 5 3 separator 0.98672116 ¶ 1831 1833 W4280516099.pdf 5 4 text 0.99956477 "When examined at the genus level, patterns in genera roughly follow these species-level patterns, with China (301), the USA (279), and Brazil (267) hosting the greatest number of genera (Fig. 6d). The number of genera in trade varies signi ficantly between countries, with the highest number in trade coming from Brazil with at least 106 genera in trade, as well as high numbers in North America and Australia (Fig. 6e). The highest percentage of genera in trade come from various island states, as well as Cambodia, and a number of West African states (Fig. 6f)." 1833 2412 W4280516099.pdf 5 5 separator 0.983017 ¶ 2412 2414 W4280516099.pdf 5 6 text 0.9995644 "If we examine some of the most traded genera or families of spider, many regions trade 100% of their species from groups intrade (e.g., for some genera, every species from the genera in the region was in trade), this includes theraphosids with 415 species in trade in total (41%) and up to 88 species in trade from countries such as Brazil, and the majority of species of native tarantula across most of Africa in trade, as well as most small islands. Patterns of exploitation varied between the most traded groups, with for example 40% of Theridiidae spp. from any given country in trade (particularly in Africa), up to 100% of Sparassidae spp. in trade (largely in Europe), 25% of Lycosidae spp. in trade (Middle East) and 50% of Araneidae spp. and 35% ofSalticidae spp. in trade from parts of Africa and the Middle East (Supplementary Fig. S9)." 2414 3284 W4280516099.pdf 5 7 separator 0.98513746 ¶ 3284 3286 W4280516099.pdf 5 8 text 0.999554 "For scorpions, richness peaked in Mexico with 301 species, with high levels of richness also seen in Brazil (181), the United States (140) and India (137). Patterns of trade also follow these general patterns, with the greatest number coming from Mexico (28) and South Africa (24). In terms of the percentage of species, however, whilst South Africa was moderately high at 21%, many countries were higher. Jordan trades 42% of species, Botswana 38%, Mauritania and Egypt both export 37% of species, and a further eight African countries at least 30% of species, whereas outside Africa (and parts of the Mediterranean) few countries have over 20% of species in trade (Supplementary Fig. S10)." 3286 3998 W4280516099.pdf 5 9 separator 0.99545944 ¶ 3998 4000 W4280516099.pdf 5 10 title 0.9869219 Discussion 4000 4011 W4280516099.pdf 5 11 separator 0.9954276 ¶ 4011 4013 W4280516099.pdf 5 12 text 0.99356747 "Whilst wildlife trade is now often acknowledged to be a major driver of global biodiversity losses, the potential for trade to threaten the survival of various terrestrial invertebrate species has been largely overlooked, even by regulatory frameworks such as CITES 2. Yet, some taxa (such as some arachnids) share many of the traits known in other taxa to be associated with vulnerability, such as long lifespans (exceeding 30 years in some taxa), and their popularity as pets is increasing without parallel conservation management strategies of trade for most species23. In total, we detected 1264 species in trade. Our searches for arachnid species differed markedly from our previous searches on reptiles and amphibians where LEMIS showed similar numbers of species to online search efforts. For arachnids, a startling 73.8% (993) of species were only for sale online and not listed in trade by either LEMIS or CITES. This likely stems from both a lack of regulation and ability to send “slings ”/spiderlings as well as adults through" 4013 5084 W4280516099.pdf 5 13 separator 0.86803186 ¶ 5084 5086 W4280516099.pdf 5 14 caption 0.99541605 Fig. 6 The source of traded spiders and scorpions harvested from the wild. a –cshow the source based on the origin listed in the LEMIS database. 5086 5231 W4280516099.pdf 5 15 separator 0.53120685 ¶ 5231 5233 W4280516099.pdf 5 16 caption 0.9146818 d–fshow the natural distributions of all traded spiders and scorpions based on all data sources, number of species traded are shown in supplements. N.B., 5233 5387 W4280516099.pdf 5 17 text 0.98094386 "¶ The natural distributions are only accurate to the country level, and in some cases represent extrapolation from broadly de fined distributions (e.g., a “South American ”distribution would be mapped as including all countries in South America)." 5387 5635 W4280516099.pdf 5 18 paratext 0.9846038 ARTICLE COMMUNICATIONS BIOLOGY | https://doi.org/10.1038/s42003-022-03374-0 5635 5710 W4280516099.pdf 5 19 separator 0.665403 ¶ 5710 5712 W4280516099.pdf 5 20 paratext 0.985507 6 COMMUNICATIONS BIOLOGY | (2022) 5:448 | https://doi.org/10.1038/s42003-022-03374-0 | www.nature.com/commsbio 5712 5833 W4280516099.pdf 5 0 title 0.97696114 predictive value of the LDL-C/HDL-C ratio. Matsumoto 0 52 W3106075561.pdf 3 1 separator 0.98819965 ¶ 52 54 W3106075561.pdf 3 2 text 0.99497414 "I et al. [ 6] analyzed 687 patients who underwent PCI (mean age 67.7 ± 9.9 years, mean follow-up years = 2.75 years) and found a positive association between the LDL-C/HDL-C ratio and CVD. They suggested that theLDL-C/HDL-C ratio should be controlled below 1.5." 54 322 W3106075561.pdf 3 3 separator 0.95659953 ¶ 322 324 W3106075561.pdf 3 4 text 0.9960455 "Zhong et al. [ 7] enrolled 1937 acute coronary syndrome (ACS) patients (mean age 64.0 ± 10.8 years, mean follow- up =1.00 years), and found that a high LDL-C/HDL-C ratio was associated with an increased risk of CVD. They" 324 551 W3106075561.pdf 3 5 title 0.9866903 Table 1 Baseline Characteristics of the Cohort Per Quintiles of the LDL-C/HDL-C ratio 551 636 W3106075561.pdf 3 6 separator 0.9611839 ¶ 636 638 W3106075561.pdf 3 7 table 0.992904 "Characteristics* Quintiles of the LDL-C/HDL-C ratio Pvalue Q1 (< 1.16) Q2 (1.16 –1.67) Q3 (1.67 –2.10) Q4 (2.10 –2.79) Q5 ( ≥2.79) N 1387 1389 1389 1387 1389 Demographics Age, years 71.75 ± 5.51 71.67 ± 5.59 71.10 ± 5.36 70.78 ± 5.06cf70.69 ± 4.89dg< 0.001 Male, % 836 (60.27) 691 (49.75)a629 (45.28)b581 (41.89)cf607 (43.70)d< 0.001 BMI, kg/m220.85 ± 4.95 21.91 ± 3.26a22.77 ± 3.07be23.56 ± 3.25cfh24.15 ± 3.18dgij< 0.001 Smoking, % < 0.001 Never 638 (46.00) 732 (52.74) 778 (56.01) 788 (56.85) 768 (55.33) Former 263 (18.96) 258 (18.59) 283 (20.37) 260 (18.76) 259 (18.66) Current 486 (35.04) 398 (28.67)a328 (23.61)b338 (24.39)c361 (26.01)d Alcohol consumption, % 473 (34.10) 297 (21.40)a241 (17.35)b222 (16.02)cf199 (14.34)dg< 0.001 History of disease, % Stroke 74 (5.34) 78 (5.62) 90 (6.48) 90 (6.49) 130 (9.36)d0.001 CVD 75 (5.41) 95 (6.84) 86 (6.19) 89 (6.42) 89 (6.41) 0.620 Diabetes 158 (11.39) 180 (12.96) 206 (14.83) 274 (19.75)cf354 (25.49)dgi< 0.001 Blood pressure Systolic BP, mmHg 149.30 ± 18.83 149.53 ± 18.69 150.66 ± 17.87 150.47 ± 18.18 150.33 ± 18.47 0.199 Diastolic BP, mmHg 84.88 ± 10.86 85.22 ± 10.71 85.77 ± 10.22 85.32 ± 10.07 86.04 ± 10.07 0.030 Lipids TC, mmol/L 4.68 ± 0.95 4.95 ± 0.97a5.15 ± 1.03be5.37 ± 1.07cfh5.68 ± 1.19dgij< 0.001 TG, mmol/L 0.98 ± 0.44 1.24 ± 0.61a1.47 ± 0.72be1.89 ± 1.03cfh2.37 ± 1.34dgij< 0.001 LDL-C, mmol/L 2.21 ± 0.53 2.68 ± 0.55a2.98 ± 0.62be3.24 ± 0.67cfh3.64 ± 0.78dgij< 0.001 HDL-C, mmol/L 2.03 ± 0.46 1.74 ± 0.36a1.59 ± 0.33be1.45 ± 0.30cfh1.27 ± 0.27dgij< 0.001 LDL-C/HDL-C ratio 1.10 ± 0.20 1.54 ± 0.10a1.88 ± 0.10be2.24 ± 0.11cfh2.89 ± 0.41dgij< 0.001" 638 2303 W3106075561.pdf 3 8 separator 0.5125759 ¶ 2303 2305 W3106075561.pdf 3 9 table 0.9881912 "Other plasma parameters Hcy,μmol/L 19.10 ± 11.19 19.32 ± 11.28 18.91 ± 11.10 19.18 ± 11.94 19.72 ± 12.54 0.439 FBG, mmol/L 5.90 ± 1.23 6.00 ± 1.35 6.06 ± 1.64 6.19 ± 1.46cf6.43 ± 1.81dgij< 0.001 Albumin, g/L 45.57 ± 4.27 45.83 ± 4.06 45.90 ± 3.98 46.18 ± 3.89c45.98 ± 3.96 0.002 SUA, μmol/L 413.30 ± 123.79 411.09 ± 114.47 415.57 ± 118.22 429.92 ± 122.14cf450.71 ± 120.26dgij< 0.001 eGFR, ml/min/1.73m281.52 ± 19.56 81.51 ± 18.15 81.46 ± 19.33 80.44 ± 19.26 78.26 ± 20.21dgi< 0.001 Medication use, % Antihypertensive drugs 874 (63.01) 897 (64.63) 959 (69.04) 948 (68.40) 983 (70.82)d< 0.001 Antiplatelet drugs 34 (2.45) 33 (2.38) 38 (2.74) 43 (3.10) 39 (2.81) 0.773 Glucose-lowering drugs 34 (2.45) 47 (3.38) 56 (4.03) 85 (6.13)c100 (7.20)dg< 0.001 Abbreviations: BMIbody mass index; CVD cardiovascular disease; TCtotal cholesterol; TGtriglyceride; LDL-C low density lipoprotein cholesterol; HDL-C high density lipoprotein cholesterol; SUA serum uric acid; eGFR estimated glomerular filtration rate; Hcyhomocysteine; FBG fasting blood glucose" 2305 3370 W3106075561.pdf 3 10 separator 0.49101743 ¶ 3370 3372 W3106075561.pdf 3 11 table 0.5111328 * 3372 3374 W3106075561.pdf 3 12 text 0.5523726 Data are presented as 3374 3395 W3106075561.pdf 3 13 table 0.4559112 number 3395 3402 W3106075561.pdf 3 14 text 0.46757612 3402 3403 W3106075561.pdf 3 15 table 0.46900412 (%) 3403 3406 W3106075561.pdf 3 16 text 0.80079424 "or mean ± standard deviation aindicates a significant difference between Q2 and Q1, P< 0.001;bindicates a significant difference between Q3 and Q1, P< 0.001;cindicates a significant difference between Q4 and Q1, P< 0.001;dindicates a significant difference between Q5 and Q1, P< 0.001;eindicates a significant difference between Q3 and Q2,P< 0.001;findicates a significant difference between Q4 and Q2, P< 0.001;gindicates a significant difference between Q5 and Q2, P< 0.001;hindicates a significant difference between Q4 and Q3, P< 0.001;iindicates a significant difference between Q5 and Q3, P< 0.001;jindicates a significant difference between Q5 and Q4, P< 0.001" 3406 4084 W3106075561.pdf 3 17 paratext 0.987095 Yuet al. Lipids in Health and Disease (2020) 19:238 Page 4 of 9 4084 4156 W3106075561.pdf 3 0 text 0.932358 "variability, with mean daily temperatures ranging from −16.4°C to 34.4°C." 0 75 W2253168576.pdf 3 1 separator 0.9869682 ¶ 75 77 W2253168576.pdf 3 2 text 0.9978691 "Summary statistics for variables specifying temperature chan- ges are reported in Table 2. Miami and Houston experienced a higher percentage of days with an increase in temperature abovethe MMT between 2 neighboring days (between 25% and 40%),whereas in Stockholm almost half of the days included in thestudy period registered a decrease in temperature below theMMT. New York and Houston showed the sharpest interdayincrease (maximum: 7.2°C) and decrease (15.3°C) in tempera-ture, respectively. More elevated median DTR values had beenregistered on hot days than on cold days in each location, except for Houston, which had the highest median DTR for colddays (12.2°C) among all cities. Madrid showed the correspond- ing largest median value on hot days (12.7°C). The de finitions of temperature changes were based on the estimated MMT,which showed limited variation between cities, in the range18.5°C –23°C. However, the corresponding values on a relative scale of minimum mortality percentiles were more dependenton the climate, and varied from the 25th percentile in Miami tothe 94th percentile in London. Moderate-to-low correlations be-tween the different temperature indices were observed (Table 3)." 77 1294 W2253168576.pdf 3 3 title 0.965068 Table 2. Estimated Interday (Increase and Decrease) and Intraday (Diurnal Temperature Range on Hot and Cold 1294 1402 W2253168576.pdf 3 4 separator 0.48880383 ¶ 1402 1403 W2253168576.pdf 3 5 title 0.9401116 Days) Changes in Temperature in 6 Cities, 1985 –2010a 1403 1457 W2253168576.pdf 3 6 separator 0.9694779 ¶ 1457 1459 W2253168576.pdf 3 7 title 0.502949 1459 1460 W2253168576.pdf 3 8 table 0.98717815 "Temperature Measure and Study SiteNo. of Daysb %Change in Temperature, °C Minimum 25th Percentile Median 75th Percentile Maximum Interday change Increase in temperature, °C London, United Kingdom 230 4.5 0 0.4 0.9 1.7 3.6 Madrid, Spain 1,479 19.3 0.1 0.6 1.1 1.9 5.8 Stockholm, Sweden 329 4.3 0 0.4 0.8 1.4 3.7New York, New York 1,011 12.6 0.1 0.6 1.2 2.2 7.2 Miami, Florida 3,059 38.1 0.1 0.3 0.8 1.1 5.6 Houston, Texas 1,994 24.8 0.1 0.6 0.8 1.4 5.6 Decrease in temperature, °C London 2,437 47.7 0 0.6 1.2 2.1 7 Madrid 2,490 32.5 0.1 0.5 1.2 2.1 8Stockholm 3,600 46.9 0 0.6 1.4 2.5 11.1New York 3,123 39 0.2 1.1 2.2 3.9 13.6 Miami 1,031 12.8 0.2 0.5 1.6 3.3 10.8 Houston 2,007 25 0.2 1.1 2.2 4.4 15.3 Intraday change DTR on hot days, °C c London 327 6.4 4.9 9.2 11.4 13.1 19.1 Madrid 2,627 34.3 3.3 11.3 12.7 13.9 19.1 Stockholm 495 6.5 0.5 8.6 10.9 13 17.6 New York 1,645 20.5 2.8 7.2 8.3 10 22.2Miami 6,067 75.5 2.2 6.1 7.2 8.3 16.7Houston 3,771 46.9 1.7 8.9 10.6 12.2 21.7 DTR on cold days, °C c London 4,786 93.6 1 4.8 6.6 8.6 17.1 Madrid 5,027 65.5 0.6 6 8.3 10.6 17.2 Stockholm 7,149 93.2 0.1 3.2 5.9 8.9 21.4 New York 6,383 79.4 1.1 5 7.2 9.4 23.9Miami 1,967 24.5 2.2 7.8 9.5 11.1 18.3 Houston 4,258 53.0 1.1 8.3 12.2 15 26.7" 1460 2752 W2253168576.pdf 3 9 separator 0.98678446 ¶ 2752 2754 W2253168576.pdf 3 10 table 0.6809532 Abbreviations: DTR, diurnal range of temperature; PMM, percentile of minimum mortality. 2754 2842 W2253168576.pdf 3 11 separator 0.97590697 ¶ 2842 2844 W2253168576.pdf 3 12 text 0.35799184 2844 2845 W2253168576.pdf 3 13 table 0.60285777 "aTemperature of minimum mortality (computed from the regression model in each city) and temperature PMM: London, 20.0°C (94th PMM); Madrid, 18.5°C (66th PMM); Stockholm, 19.0°C (94th PMM); New York, 23.0°C (80th PMM); Miami, 23.0°C (25th PMM); Houston, 23.0°" 2845 3107 W2253168576.pdf 3 14 text 0.4995076 C 3107 3108 W2253168576.pdf 3 15 table 0.55202115 (53rd 3108 3114 W2253168576.pdf 3 16 text 0.5181473 PMM). ¶ 3114 3122 W2253168576.pdf 3 17 table 0.57500786 "bNumber of days on which the DTR differed from zero. cDays with a D" 3122 3192 W2253168576.pdf 3 18 text 0.49615854 TR 3192 3194 W2253168576.pdf 3 19 table 0.6769744 value of zero were excluded.Association of Temperature Variation With Mortality 3194 3274 W2253168576.pdf 3 20 text 0.25233153 289 3274 3278 W2253168576.pdf 3 21 separator 0.91416496 ¶ 3278 3280 W2253168576.pdf 3 22 paratext 0.987808 Am J Epidemiol. 2016;183(4):286 –293Downloaded from https://academic.oup.com/aje/article/183/4/286/2195570 by guest on 17 May 2024 3280 3411 W2253168576.pdf 3 23 separator 0.99591726 ¶ 3411 3413 W2253168576.pdf 3 0 paratext 0.9887225 Int. J. Environ. Res. Public Health 2017 ,14, 592 11 of 16 0 58 W2620998393.pdf 10 1 separator 0.9873337 ¶ 58 60 W2620998393.pdf 10 2 title 0.98907804 4. Discussion 60 74 W2620998393.pdf 10 3 separator 0.99579626 ¶ 74 76 W2620998393.pdf 10 4 text 0.9995838 "A growing body of epidemiological evidence indicates that ambient air pollution has adverse effects on pregnant women and fetal development [ 25,26]. PM 2.5could even attribute 3.2 million premature deaths per year, according to the survey conducted by Global Burden of Disease (GBD) [ 3]." 76 370 W2620998393.pdf 10 5 separator 0.91561806 ¶ 370 372 W2620998393.pdf 10 6 text 0.9997138 "It is widely known that chemical compositions of PM 2.5can remarkably influence toxicity. According to a previous study, in which PM 2.5collected in the same area, the PM 2.5exhibited high densities of O, Si, C, Fe, Ca, Mg, Al, K, and S [ 27]. Prior reports have suggested that inhaled particulate matter may potentiate innate immune function [ 6], while the mechanism of PM 2.5exposure during pregnancy served as a stimulus for serum T cell activation has not been well described. Maternal immune function changes could extend to lactation or even future, resulting in a long-term impact on health for both mother and her offspring [28]." 372 1022 W2620998393.pdf 10 7 separator 0.9696004 ¶ 1022 1024 W2620998393.pdf 10 8 text 0.9995738 "We used animal models to investigate the influence of PM 2.5exposure on maternal immunity, oxidative stress, and inflammation indicators. The intratracheal instillation dosage of PM 2.5was determined on the basis of previous researches [ 13,29] and our pre-experiment. The results of our present research indicated that PM 2.5exposure during pregnancy had great impact on T-lymphocyte subsets proportion, serum cytokines, and biomarkers of systemic oxidative injuries in maternal peripheral blood." 1024 1530 W2620998393.pdf 10 9 separator 0.9078325 ¶ 1530 1532 W2620998393.pdf 10 10 text 0.99959695 The activity of T-lymphocyte subsets is an important indicator of immune homeostasis [ 30]. 1532 1624 W2620998393.pdf 10 11 separator 0.9154472 ¶ 1624 1626 W2620998393.pdf 10 12 text 0.99964964 "A report identified three critical phases of immune development during pregnancy: (1) Weeks 8–10: initiation of hematopoiesis; (2) Weeks 10–16: hematopoietic cell migration and progenitor cell expansion; (3) Week 16–birth: colonization of bone marrow and thymus [ 31]. On our study, dams were exposed to PM 2.5throughout pregnancy. Our research showed that PM 2.5exposure during pregnancy may increase the number of CD3+CD4+ and CD3+CD8+ T lymphocytes, breaking the original homeostasis and activating the immunology response. Elevated levels of serum IL-2, IL-6, and IL-8 were also observed in dams, which indicates the activation of severe systemic inflammatory reaction . Liu et al. have released a similar result that a significant increase of serum IL-6 was examined in dams, who were exposed to PM 2.5on Day 10 and Day 18 during gestation with the dose of 15 mg/kg [ 29]." 1626 2519 W2620998393.pdf 10 13 separator 0.98444474 ¶ 2519 2521 W2620998393.pdf 10 14 text 0.9997076 "The reason of why serum TNF- in Group B was lower than that of Group A was still unclear, although Aztatzi-Aguilar et al. also observed that TNF- level of kidney cortices was decreased in the PM 2.5 intervention group [ 32]. Oxidative stress occurred in the dams with PM 2.5exposure, as a decreased level of CAT and an increased level of HO-1 were detected significantly. CAT is an anti-oxidant enzyme that converts hydrogen peroxide to water and oxygen and the decreased level of CAT means decreased anti-oxidant capacity. HO-1 is an enzyme that may catalyze the process of degrading heme to generate CO, biliverdin, and free iron [ 33], playing an important role in immunoregulation and oxidative stress defense [ 34,35]. The expression of HO-1 in response to oxidative stress suppresses the release of endogenous proinflammatory ligands from injured cells, thus further promoting the process of relieving inflammation and homeostasis reestablishment [ 35]. It should be noted that, in the PM 2.5group, there was increased activity of HO-1, which suggested a self-protection effect against oxidative damage." 2521 3652 W2620998393.pdf 10 15 separator 0.9797575 ¶ 3652 3654 W2620998393.pdf 10 16 text 0.9996821 "It is infeasible to solve PM 2.5pollution thoroughly in a short period due to economic and social impact factors, so we hope to boost health against the injury caused by PM 2.5through diet intervention in our daily life. Supported by literature, oxidative damage is regarded as one of the mechanisms by which PM 2.5contributes to adverse effects on the human body, with the definite mechanisms remaining unclear so far. Quercetin, a common flavone widely found in fruits and vegetables, is a powerful antioxidant and free radical scavenger [ 36]. It can be acquired from a normal diet, whereas its content is not sufficient enough and the intake varies in different groups of people. Quercetin has been reported to show no maternal or fetal toxicity, even with a daily intake of 2000 mg/kg body weight during gestation in rats [ 37]. Referring to previous research [ 38], we determined the following three doses of quercetin: 50, 100, and 200 mg/kg." 3654 4619 W2620998393.pdf 10 0 paratext 0.984295 The 9th AIC 2019 on Sciences & Engineering (9thAIC-SE) 0 54 W3015210213.pdf 3 1 separator 0.5121748 55 56 W3015210213.pdf 3 2 paratext 0.9578724 "¶ IOP Conf. Series: Materials Science and Engineering 796 (2020) 012020 IOP Publishing doi:10.1088/1757-899X/796/1/012020 2" 56 185 W3015210213.pdf 3 3 separator 0.804244 "¶ ¶ ¶ ¶" 186 208 W3015210213.pdf 3 4 text 0.9996944 "operating, while the remaining 80% usually disappea r from t he mark et within a year , as opposed to large c ompanies that remain in business. Many SMEs decide against introducing management within their work guidelines, since these businesses are mostly unaware that applying knowledge in the management, organi zation, planni ng, and control of their operations can really create a difference in their results and make them more competi tive in the national and international markets. This same scenario is experienced by many local organizations within the country." 208 794 W3015210213.pdf 3 5 separator 0.89567983 ¶ 796 798 W3015210213.pdf 3 6 text 0.99973303 "All previous wor ks describe comprehensive management mo dels for large serial production line companies, a scenario that does n ot favour the Peruvian jewellery market. Moreover, no model or research study has even been validated in operating SMEs. Finally, no ne of the compreh ensive management models developed has been applied in the jewellery industry." 798 1169 W3015210213.pdf 3 7 separator 0.78017944 ¶ 1171 1173 W3015210213.pdf 3 8 text 0.9994649 "Therefore, this study proposes a 3-tier model: business units, comprised by the different areas of the company; technological support, meaning the software used for support ing ope rations; and management, which is respo nsible for planning, organizing, directing, and monitoring each busines s unit based on the three fundamental model philosophies: lean manufacturing, lean green, and culture." 1173 1579 W3015210213.pdf 3 9 separator 0.99450254 ¶ ¶ 1581 1587 W3015210213.pdf 3 10 title 0.99263847 2. State of The Art 1587 1607 W3015210213.pdf 3 11 separator 0.99465704 ¶ 1609 1611 W3015210213.pdf 3 12 text 0.99974936 "For th e literature review , we focus on studies that might contri bute to the development of different company areas. Starting with sales , and since businesses would not exist without sales, companies must plan, develop, and manage the various channels available t o the custom er for acquiring the product or service they o ffer. The multiple -equation model, as proposed by Isaac, Harald, and Sc ott [5], quantifies the impact and magnitude of the online and offline sales channels of the company, in terms of the expenses generated by both c hannels. Similarly, Abhishek, Jerath, a nd Zhang [6] propose a game theory model on reselling against the sales agency. This model also assesses which of the following channels offers the greatest benefits to companies: online sales, offl ine sales, d irect s ales, and agency resales." 1611 2471 W3015210213.pdf 3 13 separator 0.89372146 ¶ 2473 2475 W3015210213.pdf 3 14 text 0.9996972 "On the other hand, like with any other jewellery manufacturing company, the production area, where the added value is created for the product, must also be considered. To control the production flow in craft wor kshops, we use d the C obacabana technique, devel oped by Matthias Thürer [7], as an alternative proposal to the Kanban technique. Unl ike Kanban, Cobacabana adapts to variable workflows, where multiple activities must be performed at the same time, besides as sessing delive ry times by reducing production d elays. Another proposal developed by Mhargareta Gansterer [8] studies aggregate plan ning impacts on a make -to-order (MTO) environment through a comprehensive hierarchical production planning (HPP) model, which combines the use of a linear mathematical mode l with a discrete event simulation model capable of generating a positive effect on saving money and resources, planning, and on -time deliveries. In the same manner, Randhawa and Ahuja [9] seek to improve qual ity, productio n, cost optimization, moral value s, and work culture in general for the manufacturing industry through the successful implementation of the 5S tool." 2475 3671 W3015210213.pdf 3 15 separator 0.9081576 ¶ 3673 3675 W3015210213.pdf 3 16 text 0.99969983 "Moreover, since this is a MTO environment, the activities of the workers must be effectively managed to pro vide qu ick response times. For th ese purposes, Nallusamy developed a comprehensive production management mode to addr ess downtime in companies by applying single -minute exchange of die (SMED) and Kaizen, common lean manufacturing tools, at ea ch workstation . Simil arly, Saravanan’s lean app roach considers that a successful SMED implementation is able to increase productivi ty and reduce downtime for both machines and operators. On the other hand, author Suganthini Rekha argues that value -stream m apping (VSM) i dentifi es manufacturing wastes to determine and eliminate actions that do not add value, which in turn improves compa ny productivity." 3675 4465 W3015210213.pdf 3 17 separator 0.91485333 ¶ 4466 4468 W3015210213.pdf 3 18 text 0.99973255 "Finally, Bocken [10] developed a study that uses VSM to explore for a broader and more sustainable business thinking, whic h provi des a conceptual link to t he activities of the company, such as design, production, supply chains, relationshi ps, and distribution channels." 4468 4749 W3015210213.pdf 3 19 separator 0.85877156 ¶ 4751 4753 W3015210213.pdf 3 20 text 0.99929965 "In this light, supply chain management (SCM) has become a key strategic tool for improving performance and g uarante eing the competitiveness o f companies in the market [11]. For this reason, Macchion and Fornasiero assessed di fferent configurations based on a discrete event simulation by" 4753 5053 W3015210213.pdf 3 0 text 0.98769397 in contrary to 17.4 who were not (C Pearson = 0472, p<0 . 0 5 ) . 0 65 W2293608610.pdf 3 1 separator 0.99061537 ¶ 65 67 W2293608610.pdf 3 2 text 0.99787647 "Twenty percent would choose BR when they should pay for surgery, while 44 % would refuse reconstruction without re-imbursement; 36 % did not declare their opinion." 67 233 W2293608610.pdf 3 3 separator 0.92477286 ¶ 233 235 W2293608610.pdf 3 4 text 0.99718565 "Level of education was not a significant factor in the choice, which was almost the same for all groups ( p>0 . 0 5 ) ." 235 357 W2293608610.pdf 3 5 separator 0.7907997 ¶ 357 359 W2293608610.pdf 3 6 text 0.9952531 "Age was a significant factor influenced decision to undergo BR with strong correlation: ( X 2= 13.522, df=1 , p<0 . 0 5 , C Pearson = 0.493). 71.4 % of women younger than 55 years had already undergone or were going to undergo reconstruc- tive surgery, while only 14.3 % of older patients chose BR." 359 668 W2293608610.pdf 3 7 separator 0.96533364 ¶ 668 670 W2293608610.pdf 3 8 text 0.99827164 "The main reasons for refusal were fear of postoperative complications (47.4 %), priority to recovery over aesthetic(36.8 %), age, defined by the patient as “advanced ” (31.6 %), high level of acceptance of their body after ampu-tation (31.6 %), fear of breast cancer recurrence (26.3 %), fear of the pain and discomfort (15.8 %), lack of foreign body(implant) acceptance (15.8 %), fear of assymetry (10.5 %) and an unnatural effect (5.3 %) (some of the patients indicated more than one answer, and this is the reason why the indica-tions do not add up to 100 %)." 670 1243 W2293608610.pdf 3 9 separator 0.9967476 ¶ 1243 1245 W2293608610.pdf 3 10 title 0.9803122 Discussion 1245 1256 W2293608610.pdf 3 11 separator 0.9956175 ¶ 1256 1258 W2293608610.pdf 3 12 text 0.991743 "Despite various guidelines stipulating the proposal of recon-struction in each case of planned mastectomy, the majority ofpatients do not undergo BR after mutilating surgery. Data published in the Annual Reports of the National Mastectomy and Breast Reconstruction (NMBR) Audit showed the differ-ent availability of breast reconstruction across the country [ 6]. There were several factors proposed to explain the regionalvariations, such as increased comorbidities in areas of socialdeprivation or different views of multidisciplinary teams" 1258 1806 W2293608610.pdf 3 13 separator 0.99461603 ¶ 1806 1808 W2293608610.pdf 3 14 title 0.906261 "Table 2 Crosstable. Information about the possibility of BR obtained before surgery and declared interest in reconstructive surgery (or reconstruction in the past)" 1808 1974 W2293608610.pdf 3 15 separator 0.83915734 ¶ 1974 1976 W2293608610.pdf 3 16 table 0.99565446 "Declared interest in reconstructive surgery (or reconstruction in the past)Total No Yes Information about possibility of BR obtained before surgeryNo % with information about possibility of BR obtained before surgery72.7 % 27.3 % 100.0 % % with declared interest in reconstructive surgery (or reconstruction in the past)64.0 % 27.3 % 46.8 % Yes % with information about possibility of BR obtained before surgery36.0 % 64.0 % 100.0 % % with declared interest in reconstructive surgery (or reconstruction in the past)36.0 % 72.7 % 53.2 % Total % with information about possibility of BR obtained before surgery53,2 % 46.8 % 100.0 % % with declared interest in reconstructive surgery (or reconstruction in the past)100,0 % 100.0 % 100.0 %" 1976 2742 W2293608610.pdf 3 17 separator 0.9315226 ¶ 2742 2744 W2293608610.pdf 3 18 table 0.5262226 Source: own calculations on the basis of research without missing values 2744 2817 W2293608610.pdf 3 19 title 0.9483627 Table 1 Crosstable. Obtained the information concerning breast reconstruction before and after surgery 2817 2919 W2293608610.pdf 3 20 separator 0.8760866 ¶ 2919 2921 W2293608610.pdf 3 21 table 0.9957404 "Obtained the information concerning breast reconstruction after surgeryTotal No Yes Obtained the information concerning breast reconstruction before surgeryNo Frequency 15 6 21 % within Total 34,9 % 14.0 % 48.8 % Yes Frequency 3 19 22 % within Total 7,0 % 44.2 % 51.2 % Total Frequency 18 25 43 % within Total 41.9 % 58.1 100.0 %" 2921 3269 W2293608610.pdf 3 22 separator 0.92233586 ¶ 3269 3271 W2293608610.pdf 3 23 paratext 0.27173573 Source 3271 3278 W2293608610.pdf 3 24 table 0.35570085 : own calculations on the basis 3278 3309 W2293608610.pdf 3 25 bibliography 0.3010128 of 3309 3312 W2293608610.pdf 3 26 table 0.33874097 research without 3312 3329 W2293608610.pdf 3 27 bibliography 0.28297353 missing 3329 3337 W2293608610.pdf 3 28 paratext 0.89542675 values540 J Canc Educ (2017) 32:537 –542 3337 3378 W2293608610.pdf 3 0 paratext 0.98170185 314ЛИТОСФЕРА, 2018, том 18, No 2, с. 314–321 LITHOSPHERE (RUSSIA), 2018, volume 18, No. 2, pp. 314–321 0 106 W2806180598.pdf 0 1 separator 0.9705432 ¶ 106 108 W2806180598.pdf 0 2 paratext 0.61484754 Для цитирования : Буртман В.С., Дворова А.В. (2018) Казахстанский и Таримский микроконтиненты на девонских палеотекто- 108 234 W2806180598.pdf 0 3 bibliography 0.4768877 ¶ 234 235 W2806180598.pdf 0 4 paratext 0.7399494 нических реконструкциях. Литосфера, 18(2), 314-321. DOI: 10.24930/1681-9004-2018-18-2-314-321 235 329 W2806180598.pdf 0 5 separator 0.8911922 ¶ 329 331 W2806180598.pdf 0 6 paratext 0.64845276 For citation: Burtman V.S., Dvorova A.V. (2018) Kazakhstan and Tarim microcontinents on the Devonian paleotectonic reconstructions. 331 467 W2806180598.pdf 0 7 separator 0.577752 ¶ 469 471 W2806180598.pdf 0 8 paratext 0.98574036 Litosfera, 18(2), 314-321. DOI: 10.24930/1681-9004-2018-18-2-314-321УДК 551.24 DOI: 10.24930/1681-9004-2018-18-2-314-321 471 593 W2806180598.pdf 0 9 separator 0.9912727 ¶ 593 595 W2806180598.pdf 0 10 title 0.9815078 "КазахстансКий и таримсКий миКроКонтиненты на ДевонсКих палеотеКтоничесКих реКонструКциях" 595 687 W2806180598.pdf 0 11 separator 0.9899177 ¶ 687 689 W2806180598.pdf 0 12 contact 0.9839229 "© 2018 г. в. с. Буртман, а. в. Дворова Геологический институт РАН, 119017, Москва, Пыжевский пер., д. 7, e-mail: vburtman@gmail.com" 689 825 W2806180598.pdf 0 13 separator 0.93496114 ¶ 825 827 W2806180598.pdf 0 14 paratext 0.9636874 Поступила в редакцию 25.04.2017 г., принята к печати 13.06.2017 г. 827 894 W2806180598.pdf 0 15 separator 0.99491864 ¶ 894 896 W2806180598.pdf 0 16 text 0.9995636 "По палеомагнитным данным установлено палеоширотное положение Казахстанского и Таримского микроконти- нентов в девонском периоде. Определение палеоширот основано на результатах изучения на 19 участках досклад- чатой высокотемпературной компоненты намагниченности пород. Вычислено положение центра Казахстанского микроконтинента в раннем-среднем девоне на широте 24.6 ± 5.5°, в позднем девоне – на широте 22.7 ± 4.6°. Цен- тральная часть Таримского микроконтинента в раннем-среднем девоне находилась на широте 6.1 ± 4.2°. Было предложено значительное количество палеотектонических схем Центральной Азии с различным дизайном и дета- лизацией. Среди палеотектонических реконструкций можно выделить три группы. На многих реконструкциях рас- пределение террейнов и океанических островных дуг подобно наблюдаемому ныне в Индонезии. К второй груп- пе относятся реконструкции, на которых террейны образуют дугу, которая соединяла Балтийский и Сибирский па- леоконтиненты. На реконструкциях третьей группы Казахстанский и Таримский микроконтиненты имеют изоли- рованные позиции в палеоокеане. Мы рассмотрели положение Казахстанского и Таримского микроконтинентов в 19 ордовикских палеотектонических реконструкциях, опубликованных после 2000 года. В результате, предложен путь согласования палеотектонических реконструкций с палеомагнитными данными." 896 2335 W2806180598.pdf 0 17 separator 0.9935807 ¶ 2336 2338 W2806180598.pdf 0 18 title 0.59597766 Ключевые слова 2338 2353 W2806180598.pdf 0 19 text 0.43250522 : палеомагнет 2353 2367 W2806180598.pdf 0 20 title 0.412193 изм 2367 2370 W2806180598.pdf 0 21 text 0.39733055 , Казахстан, 2370 2382 W2806180598.pdf 0 22 title 0.40194705 Тарим 2382 2388 W2806180598.pdf 0 23 text 0.35238755 , микро 2388 2395 W2806180598.pdf 0 24 title 0.44567236 континент, палеоширота, палеотектоническая 2395 2439 W2806180598.pdf 0 25 text 0.29472238 ¶ 2439 2440 W2806180598.pdf 0 26 title 0.4238233 реконструкция 2440 2454 W2806180598.pdf 0 27 separator 0.99619126 ¶ 2454 2456 W2806180598.pdf 0 28 title 0.96246916 "KazaKhstan anD tarIm mIcrOcOntInents On the DevOnIan paleOtectOnIc recOnstructIOns" 2456 2542 W2806180598.pdf 0 29 separator 0.9814223 ¶ 2542 2544 W2806180598.pdf 0 30 contact 0.9955821 "valentin s. Burtman, ariadna v. Dvorova Geological Institute of RAS, 7 Pyzhevsky line, Moscow, 119017, Russia, e-mail: vburtman@gmail.com" 2544 2684 W2806180598.pdf 0 31 separator 0.94159746 ¶ 2684 2686 W2806180598.pdf 0 32 paratext 0.9567907 Received 25.04.2017, accepted 13.06.2017 2686 2727 W2806180598.pdf 0 33 separator 0.99571335 ¶ 2727 2729 W2806180598.pdf 0 34 text 0.99957603 "Devonian latitudes of the Kazakhstan and Tarim microcontinents obtained from paleomagnetic data. Definition based on the results of the study pre-folded high-temperature components of magnetization of rocks. The article uses the results of paleomagnetic studies of Devonian sedimentary and magmatic rocks, which formed on the continental crust. In these stud- ies, conducted by various researchers, the high-temperature pre folded primary component of magnetization detected in De- vonian rocks on 19 plots. Based on that data the latitude of 24.6 ± 5.5° determined for the Center of Kazakhstan microcon - tinent in the Early-Middle Devonian and 22.7 ± 4.6° in the Late Devonian. The Early-Middle Devonian latitude 6.1 ± 4.2° determined for the Сenter of the Tarim microcontinent. A significant number of paleotectonic schemes of Asia with differ- ent design and detail were proposed. We reviewed the position of the Kazakhstan and Tarim microcontinents in 19 paleo- tectonic reconstructions published after 2000. There are three groups of paleoreconstructions among them. On many recon- structions, the location of continental terranes and island arcs of Kazakhstan and Central Asia in the Early and Middle Pa- leozoic resembles the modern structure of the Indonesian region. On other reconstructions, these terranes form an arc that connected two paleocontinents in the Paleozoic – the Baltic and the Siberian ones. In the alternative design of reconstruc- tions, the terranes have a relatively isolated position in the Paleoocean. As a result, а way of for co-ordination of matching paleotectonic reconstructions with paleomagnetic data is proposed." 2729 4464 W2806180598.pdf 0 35 separator 0.9941871 ¶ 4464 4466 W2806180598.pdf 0 36 paratext 0.36691615 Keywords: 4466 4476 W2806180598.pdf 0 37 text 0.35379663 paleomagnetism, Kazakhstan, Tarim, microcontinent, paleo-latitude 4476 4542 W2806180598.pdf 0 38 paratext 0.21951108 , 4542 4543 W2806180598.pdf 0 39 text 0.26612517 paleotectonic reconstruction 4543 4572 W2806180598.pdf 0 40 separator 0.99444896 ¶ 4572 4574 W2806180598.pdf 0 41 title 0.9786073 acknowledgements 4574 4591 W2806180598.pdf 0 42 separator 0.99635327 ¶ 4591 4593 W2806180598.pdf 0 43 text 0.998726 The studies were carried out according to the plan of the GIN RAS, themes No. 0135-2016-0009 and 0135-2018-0029. 4593 4706 W2806180598.pdf 0 0 paratext 0.9680263 "Journal of Educational Issues ISSN 2377-2263 2021, V ol. 7, No. 3, Special Issue www.macrothink.org/jei 306" 0 116 W4200166210.pdf 5 1 text 0.999457 "that the OFDES total score diff ers significantly according to th e gender variable (t = 3.00, p < 0.01). According to this finding, the m ean scores of male students ( x̄ = 2.75) are higher than the mean scores of female students ( x̄ = 2.48). In other words, it can be said that male students’ opinions for distance education are mo re positive than female students. When the scale scores are examined on the basis of factors, it is seen that the dimensions of suitability, effectiveness, and instructiveness differ signi ficantly according to the gender variable, while there is no significant difference in the sub-di mension of predispositi on. According to this finding, the mean scores of male students ( x̄ = 2.84), ( x̄ = 2.17) are higher than the mean scores of female students ( x̄ = 2.25), ( x̄ = 1.76) in the sub-dimensions of suitability and effectiveness. In the instruct iveness sub-dimension, the mean scores of female students ( x̄ = 4.30) are higher than the mean scores of male students ( x̄ = 3.89)." 116 1167 W4200166210.pdf 5 2 separator 0.99288994 ¶ ¶ 1169 1175 W4200166210.pdf 5 3 title 0.972352 Table 3. ANOVA results according to class variable 1175 1226 W4200166210.pdf 5 4 separator 0.8036037 ¶ 1227 1229 W4200166210.pdf 5 5 table 0.9955173 "1st Grade (n = 33) 2nd Grade (n = 52) 3rd Grade (n = 35) 4th Grade (n = 33) F p Significant Difference Mean Sd Mean Sd Mean Sd Mean Sd OFDES 2.77 0.39 2.42 0.57 2.65 0.61 2.77 0.52 4.17 0.00 1-2; 4-2 Personal Suitability 2.77 1.01 2.34 0.98 2.53 1.22 2.89 1.22 2.95 0.03 4-2 Effectiveness 2.21 0.98 1.71 0. 76 1.97 1.07 2.16 1.13 2.32 0.07 - Instructiveness 4.15 1.05 4.06 1. 19 4.14 1.19 3.99 1.07 0.15 0.93 - Predisposition 1.88 0.59 1.81 0.86 2.04 0.98 1.92 0.90 0.53 0.67 -" 1230 1738 W4200166210.pdf 5 6 separator 0.96739846 ¶ ¶ 1739 1745 W4200166210.pdf 5 7 text 0.9941705 "Table 3 shows the ANOVA test results of the stude nts’ scores on the Op inions for Distance Education scale and its sub-dimensions according to the class variable. According to the class variable, the analyses show that the scor es obtained from the Op inions for Distance Education scale (F 3.149 = 4.17, p < 0.01) and Personal Suitability (F 3.768 = 2.95, p < 0.05) sub-dimension differ significan tly, whereas the scores of Effectiveness (F 3.149 = 2.32, p > 0.05), Instructiveness (F 3.149 = 0.15, p > 0.05), Predisposition (F 3.149 = 0.53, p > 0.05) sub-dimensions did not differ significantly. Tukey test, one of the post hoc tests, was used to understand between which variables there was a si gnificant difference. When the total scores obtained from the scale as a result of the test ar e examined, it is seen that the mean scores of the 1st grade students ( x̄ = 2.77) are statistically higher th an the mean scores of the 2nd grade students ( x̄ = 2.42), while the mean scores of the 4th grade students ( x̄ = 2.77) are statistically higher than the mean scores of the 2nd grade students ( x̄ = 2.42). When the scale scores are analyzed on the basis of factors, it is seen that in the personal suitability sub-dimension, the mean scores of the 4th grade students (x ̄ = 2.89) are statistically highe r than the mean scores of the 2nd grade students ( x̄ = 2.34). In other words, it can be said that the opinions of 1st and 4th grade students about distance education are positive in terms of total scale and personal suitability (Table 3)." 1745 3350 W4200166210.pdf 5 0 title 0.9600151 158 THE JOURNAL OF INDUSTRIAL 0 29 W2048977325.pdf 2 1 separator 0.99385774 ¶ 30 32 W2048977325.pdf 2 2 text 0.99955714 "In the industries the Research Laboratory of the General Electric Company is the best known; but there are a number of other large ones, those of the Western Electric Company, the du Pont Company, the Eastman Kodak Company, the National Carbon Company, The Barrett Company, the National Aniline Company, the Goodrich Company, the Goodyear Com- pany, the Brown Company, and the one of the General Electric Company at Nela Park being conspicuous instances. In addi- tion very many companies are running smaller research labora- AND ENGINEERING CHEiMISTRY Vol. 14, No. 2 tories. It looks also as though in the plants the ratio of chemists to engineers was going to increase considerably. Of course, the almost insane demand for chemists that prevailed at the end of the war has ceased and most companies are now dis- charging chemists as well as other technical men. When the present industrial depression is over, things will adjust themselves and we shall get on a normal basis. It looks now as though the next thirty years would be the period of the chemist just as the previous thirty years were the period of the engineer." 32 1208 W2048977325.pdf 2 3 separator 0.99611497 ¶ 1209 1211 W2048977325.pdf 2 4 title 0.97800636 SOCIAL INDUSTRIAL RELATIONS 1211 1239 W2048977325.pdf 2 5 separator 0.9800346 ¶ 1240 1242 W2048977325.pdf 2 6 title 0.48429 1242 1243 W2048977325.pdf 2 7 text 0.4330938 Charity 1243 1250 W2048977325.pdf 2 8 separator 0.73232996 ¶ 1251 1253 W2048977325.pdf 2 9 text 0.5445592 By H. W. Jordan 1253 1269 W2048977325.pdf 2 10 contact 0.33825365 1270 1271 W2048977325.pdf 2 11 text 0.49815053 ¶ SYRACUSE, ?SEW YORK 1271 1292 W2048977325.pdf 2 12 separator 0.93757993 ¶ 1293 1295 W2048977325.pdf 2 13 text 0.9994261 "We have just passed through the annual newspaper orgy of vicarious charity in behalf of each city’s One Hundred Neediest Families. The lavish expenditure of printer’s ink and other folk’s money revealed little effort to prevent the return next Christmas of the same families, reenforced by new members and supplemented by other households attracted to the honey of newspaper readers’ cash; each donation duly announced in the paper." 1295 1749 W2048977325.pdf 2 14 separator 0.9479382 ¶ 1750 1752 W2048977325.pdf 2 15 text 0.99964625 "One hardship the war brought upon these Neediest Families was jobs. Although the managers of the professional charity organizations succeeded in holding their staffs intact, their clien- tele dwindled almost to the vanishing point. Plenty of work, lack of drink through prohibition, and diversion of public emo- tion to the soldiers and of public money to Liberty Bonds, nearly killed the vested interests of organized charity. We came near proving that “Poverty would cease if charity be stopped for a year.”" 1752 2286 W2048977325.pdf 2 16 separator 0.9409704 ¶ 2287 2289 W2048977325.pdf 2 17 text 0.99942327 "Now that peace rages, the army of constitutionally needy are back in their city trenches. Their crushing cost of maintenance merits serious consideration. Syracuse and other cities have organized Community Chests to handle the collection of charity funds by an annual drive, followed by distribution of the money pro rata to each nice, certified charity." 2289 2659 W2048977325.pdf 2 18 separator 0.85650927 ¶ 2660 2662 W2048977325.pdf 2 19 text 0.9995534 "OF HANDLING MONEY. They offer an opportunity of doing a splendid social industrial service by applying science through research upon charity, as science has been applied through re- search to industry. If chemists and engineers can secure ap- pointments on the directing boards of Community Chests they will be able to undertake this sorely needed social study." 2662 3039 W2048977325.pdf 2 20 separator 0.82313466 ¶ 3040 3042 W2048977325.pdf 2 21 text 0.9996202 "But if Community Chesi management be restricted to captains of finance, with little scientific thought and puny social imagina- tion, who make the Chests mere money feed tanks, they will only aggravate pauperism." 3042 3264 W2048977325.pdf 2 22 separator 0.90857816 ¶ 3265 3267 W2048977325.pdf 2 23 text 0.9994997 "Specialized employment, herding of people in rented quarters, feeding folks on factory,cooked, paper packaged food, complete dependence upon wages or salary for a livelihood with no re- course to farms or villages for partial or temporary relief from unemployment, living conditions that promote tuberculosis, venereal disease and other crowd maladies; these and similar circumstances of city life that spring from modern industry, have forced 15 to 20 per cent of our people below the line of ade- quate, permanent self-support. Only in times of extremely abundant employment does the percentage fall to 10." 3267 3903 W2048977325.pdf 2 24 separator 0.8500477 ¶ 3904 3906 W2048977325.pdf 2 25 text 0.9934345 "In a herd of livestock if 10 to 20 per cent yielded no milk or wool or eggs, and were unfit for meat, the owner would be COMMUNITY CHESTS HAVE A FAR GREATER MISSION THAN THAT CITY POVERTY IS A SOCIAL BY-PRODUCT OF MODERN INDUSTRY. bankrupt. No farmer would permit his stock to sink to that low ebb, except through malignant disease or prolonged drought." 3906 4269 W2048977325.pdf 2 26 separator 0.93355596 ¶ 4270 4272 W2048977325.pdf 2 27 text 0.9997113 "Yet industry which depends upon capable, contented labor to produce goods, and on normal thrifty people to consume them is confronted by a population of which one-fifth, on the average, has been surrounded by conditions beyond their indi- vidual control, which make them collectively a steadily increasing economic and social dead load; economic because if employed they are incompetent, and if idle they must be fed, clothed, and housed; social because every adult man and woman of them is a persistent voter." 4272 4807 W2048977325.pdf 2 28 separator 0.9419033 ¶ 4808 4810 W2048977325.pdf 2 29 text 0.9992593 "They roll up huge metropolitan majorities in election of politicians who cater more and more to the selfish, emotional demands of the ignorant and unthinking. They elect men who vote huge sums in long term bonds for short-lived improvements; men who enact laws of momentary expediency designed to regulate and restrict engi- neering industry to the verge of bankruptcy." 4810 5198 W2048977325.pdf 2 30 separator 0.77188075 ¶ 5199 5201 W2048977325.pdf 2 31 text 0.9994415 "When the chemical industry, the railroads, the telephone or electric power companies, or other enterprises of modern applied science seek legal enactments in harmony with economic and biological laws we are overruled by these legislators." 5201 5449 W2048977325.pdf 2 32 separator 0.9873301 ¶ 5450 5452 W2048977325.pdf 2 33 text 0.99956447 "BER’S Atlantic Monthly, Mrs. Cornelia Cannon, wife of the dis- tinguished biologist, Walter B. Cannon, discusses the more salient features of social charity. She sets forth the fact that charity does little more than wrap costly sterilized bandages around social cut fingers that would not have been cut if we had whittled away from us. She reaches the co?clusion that charity is a practical failure because it is neither constructive, pro- gressive nor preventive." 5452 5939 W2048977325.pdf 2 34 separator 0.9796294 ¶ 5940 5942 W2048977325.pdf 2 35 text 0.9995877 "“Philanthropists belong to the class on which the injustices of our present basis of society have borne lightly,” says Mrs. Cannon. “They serve unconsciously as a bulwark of the status quo, for whose defects they are ready and eager to apply pallia- tives. They are the great menders and patchers-up of society, not the surgeons who cut deep into the festering sore and scrape the bone. They express the tenderness and pity of man, not his reasoning intelligence. So long as we placate our intelli- gence and pacify our consciences by our philanthropies, we put off the day of attack on the sources of poverty.”" 5942 6581 W2048977325.pdf 2 36 separator 0.91025865 ¶ 6582 6584 W2048977325.pdf 2 37 text 0.998806 "She urges more effective citizenship of intellectual people, to the end that we root up the causes of poverty. This submerged fifth dominates city elections." 6584 6745 W2048977325.pdf 2 38 separator 0.9769505 ¶ 6746 6748 W2048977325.pdf 2 39 text 0.93117976 IN AN ARTICLE, “PHILANTHROPIC DOUBTS,” IN LAST SEPTEM- 6748 6803 W2048977325.pdf 2 40 separator 0.88100195 ¶ 6804 6806 W2048977325.pdf 2 41 text 0.9496641 It is merely static. 6806 6827 W2048977325.pdf 2 42 separator 0.9758357 ¶ 6828 6830 W2048977325.pdf 2 43 title 0.9534669 RURAL AND VILLAGE COMMUNITIES HAVE NO POVERTY OF THE 6830 6883 W2048977325.pdf 2 44 separator 0.9506867 ¶ 6884 6886 W2048977325.pdf 2 45 text 0.99724424 "Modern industry has SORT THAT BURDENS INDUSTRIAL CITIES. brought modern poverty. Highly specialized industry has stripped the individual of his resources of individuality, even to the extent that he no longer prepares his own food or shines his own shoes. His amusements have become passive and commercial. Eighteen thousand people sitting, watching eighteen men hired to play baseball, is the national game. Nat- urally, under these conditions, when life’s burdens grow heavy, the individual with minor ambition lies down and lets the com-" 6886 7451 W2048977325.pdf 2 0 paratext 0.9017664 "5 Jones et al. Immunosuppression by Lymphatic Metastasis Frontiers in Oncology | www.frontiersin.org February 2018 | Volume 8 | Article 36which are critical for T cell survival and guidance, respectively." 0 210 W2793716456.pdf 4 1 separator 0.9923575 ¶ 211 213 W2793716456.pdf 4 2 text 0.9996703 "The reduction in IL-7 and CCL21 resulted in disruption of the TDLN architecture, with loss of clear delineation between B and T cell zones. In a separate study, the loss of FRC CCL21 in the TDLN was associated with disorganized T cell and B cell zones in premetastatic LNs (57). The perturbation of LN architecture due to altered FRC signaling molecules suggests altered immune responses to tumors. Since LNs are priming sites for adaptive immune responses, the disordered LN architecture may fail to elicit systemic protection from subsequent heterogeneous cancer cell clones that arrive in the TDLN (56). In metastatic LNs, col- lagen production was increased relative to tumor-free LNs (58). Although unclear whether recruited fibroblasts, FRCs, or cancer cells are the source of additional collagen, the investigators specu- late that the increased density of collagen fibers may allow cancer cells to adhere and migrate within metastatic LNs. It is unknown how tumor cells influence FRC transcriptional status." 213 1263 W2793716456.pdf 4 3 separator 0.9963831 ¶ 1263 1265 W2793716456.pdf 4 4 title 0.992882 TUMOR CeLL MiGRATiOn TO Lns 1265 1293 W2793716456.pdf 4 5 separator 0.9939125 ¶ 1293 1295 W2793716456.pdf 4 6 text 0.99965626 "Cancer cells enter lymphatic vessels and travel with the lymph to establish LN metastasis (59). Cancer cells may actively migrate into lymphatic capillaries in response to molecular cues (19, 60) or they may passively enter into lymphatic capillaries (19, 60)." 1295 1562 W2793716456.pdf 4 7 separator 0.83435917 ¶ 1563 1565 W2793716456.pdf 4 8 text 0.9997177 "Metastasis to the LN likely depends on a combination of intrinsic cancer cell properties and signals in the tumor microenviron- ment. VEGF-C and lymphatic flow both upregulate CCL21 in lymphatic endothelium (19, 61), attracting CCR7 + tumor cells (62). In a triple-negative breast cancer model, CCL21 was suf-ficient to recruit RORγt + innate lymphoid cells (ILCs) into the primary tumor and promote metastasis to LNs (63). Furthermore, CXCL13 was required for clustering of ILCs and induction of epithelial–mesenchymal transition, likely driving invasion of cancer cells. In breast cancer patients, the presence of ILCs was significantly associated with lymphatic invasion at the primary tumor." 1565 2285 W2793716456.pdf 4 9 separator 0.93735236 ¶ 2285 2287 W2793716456.pdf 4 10 text 0.9995457 "Several studies have shown that another chemokine, CXCL12, facilitates lymphatic metastasis of CXCR4 + tumor cells (64– 66)." 2287 2417 W2793716456.pdf 4 11 separator 0.9372253 ¶ 2418 2420 W2793716456.pdf 4 12 text 0.99972624 "CXCL12 expression is found on lymphatic vessels within primary tumors and guides CXCR4+ melanoma cells toward lymphatic vessels. Migration and invasion of CXCR4+ papillary thyroid carcinoma cells are dependent on CXCL12, which was produced by senescent cancer cells at the invasive border (67)." 2420 2724 W2793716456.pdf 4 13 separator 0.83743423 ¶ 2725 2727 W2793716456.pdf 4 14 text 0.9996127 "These senescent cells invaded lymphatic vessels and persisted in metastatic foci, suggesting that they may promote lymphatic metastases. CXCR4 is also expressed on the surface of LECs (68) and is critical for lymphangiogenesis through CXCL12 stimula- tion, independent of the VEGFR-3 pathway (68). Thus, targeting the CXCR4/CXCL12 may provide a dual benefit of inhibiting cancer cell migration and lymphangiogenesis to curb lymphatic metastasis." 2727 3190 W2793716456.pdf 4 15 separator 0.9819337 ¶ 3190 3192 W2793716456.pdf 4 16 text 0.99970335 "After entry of cancer cells into lymphatic vessels, it is thought that lymph flow allows cancer cells to traverse the collecting lymphatic vessel network until they reach TDLNs (59). Based on 3D modeling, it was predicted that smaller breast cancer cells may have a survival advantage over larger breast cancer cells in the lymphatic circulation because of the lower wall shear stress that they encounter (69). Several studies have shown that inflamma-tion causes dilation and inhibits contractile ability of collecting lymphatic vessels (70, 71). More work needs to be done to deter - mine if tumor-induced collecting lymphatic dilation (10, 22, 59) or reduced contraction (72) enhances tumor cell dissemination by decreasing the shear stress on cancer cells. It is known that tumor cells can arrest within lymphatic vessels while “in-transit” to LNs (73). Compromised barrier integrity of lymphatic vessels may allow arrested cancer cells to escape lymphatic vessels and form metastases (74, 75). Additional characterization of the mechanism of how tumor cells attach to lymphatic endothelium and grow within lymphatic vessels is needed to treat in-transit metastases." 3192 4398 W2793716456.pdf 4 17 separator 0.9806048 ¶ 4398 4400 W2793716456.pdf 4 18 text 0.9997431 "Recently, the chemokine CCL1 and its receptor CCR8 were demonstrated to be important for melanoma cell entry into TDLNs. CCL1 is produced by SCS LECs and mediated entry of CCR8 + melanoma cells into LNs (60). Tumor cells in the SCS can also bypass the LN parenchyma and drain through cortical and medullary sinuses to exit LNs via efferent lymphatic vessels (76)." 4400 4773 W2793716456.pdf 4 19 separator 0.9783628 ¶ 4774 4776 W2793716456.pdf 4 20 text 0.9996159 "The enzyme lipoxygenase 15 (ALOX15) metabolizes arachi-donic acid to 12(S)-hydroxyeicosatetraenoic acid [12(S)-HETE] and 15(S)-hydroxyeicosatetraenoic acid [15(S)-HETE]. Cancer cell-derived 12(S)-HETE forms discontinuities in the walls of lymphatic vessels, allowing LN metastases to invade nodal lymphatic vessels (77). The fate of these cancer cells is unclear, although TDLN lymphangiogenesis has been reported to be involved in further lymphatic spread of human breast cancer (78) and the presence of lymphatic vessel invasion by LN metastases is associated with worse survival (79). It is possible that cancer cells circulate to additional nodes through lymphatic vessels and eventually enter the systemic circulation through the thoracic duct." 4776 5553 W2793716456.pdf 4 21 separator 0.99582434 ¶ 5553 5555 W2793716456.pdf 4 22 title 0.9925951 iMMUne ev ASiOn in TDLns 5555 5580 W2793716456.pdf 4 23 separator 0.6140013 ¶ 5580 5582 W2793716456.pdf 4 24 title 0.9832086 Macrophages 5582 5594 W2793716456.pdf 4 25 separator 0.9921383 ¶ 5594 5596 W2793716456.pdf 4 26 text 0.99975234 "Lymph node SCS macrophages are the first line of defense against tumor cells entering the LN. SCS macrophages capture microbes, antigen–antibody complexes and dead cancer cells for delivery of these antigens to nearby immune cells (80, 81). In premetastatic LNs, an experimental antigen (a fluorescent protein overex- pressed in tumor cells) from the primary tumor was captured by SCS macrophages and distributed to follicular DCs, resulting in antibody production against the antigen (82). SCS macrophages can also directly cross-present tumor antigens to CD8 T cells (81)." 5596 6191 W2793716456.pdf 4 27 separator 0.9530439 ¶ 6192 6194 W2793716456.pdf 4 28 text 0.9997408 "Sinus macrophages in regional LNs of CRC patients made direct contact with CD8 T cells and a high density of sinus macrophages is associated with increased overall survival (83). On the other hand, tumor-associated macrophages are often associated with poor prognosis and promotion of tumor growth (84). Strategies to deplete TAMs include targeting colony-stimulating factor 1-receptor (CSF1-R) (85), which controls macrophage chemot- axis. Interestingly, an increase in the burden of LN metastases was found following treatment with an anti-CSF1-R antibody (86). This increase in metastatic burden was associated with the loss of SCS macrophages due to anti-CSF1-R therapy (86)." 6194 6891 W2793716456.pdf 4 0 paratext 0.9784889 18 Sport Mont 18 (2020) 1 0 25 W4237257459.pdf 3 1 separator 0.9020671 ¶ 25 27 W4237257459.pdf 3 2 title 0.967468 GREEK DANCES AND PREFERENCE FOR GROUP WORK AT SCHOOL | L. DARGINIDOU ET AL. 27 104 W4237257459.pdf 3 3 text 0.9950575 "tion, and acceptance of the distinction of roles. It seems that the adolescents who participate in recreational activities with Greek dances have learnt to overcome difficulties within the group, communicating, and helping each other. In addition, they discover rhythm, creative skills and they develop or im-prove relationships, they communicate and cooperate with peers and they learn to obey rules and accept limitations (Likesas, Tsapakidou, Kostantinidou, & Papadopoulou, 2002).According to the results of this research, recreational pro- grammes with Greek dances that are organized at state schools or non-profit cultural societies seem to help male and female adolescents incorporate themselves into groups and develop a positive attitude towards group work. Consequently, partici-pating in recreational activities with Greek dances contributes to the adolescents’ preferring group work and developing pos- itive emotions towards it." 104 1070 W4237257459.pdf 3 4 separator 0.9963983 ¶ 1071 1073 W4237257459.pdf 3 5 title 0.90657765 Acknowledgements 1073 1090 W4237257459.pdf 3 6 separator 0.98767 ¶ 1090 1092 W4237257459.pdf 3 7 text 0.86609447 There are no acknowledgements. 1092 1123 W4237257459.pdf 3 8 separator 0.98318684 ¶ 1123 1125 W4237257459.pdf 3 9 title 0.82618225 Conflict of Interest 1125 1146 W4237257459.pdf 3 10 separator 0.9284594 ¶ 1146 1148 W4237257459.pdf 3 11 text 0.7798213 The authors declare that there are no conflicts of interest. 1148 1209 W4237257459.pdf 3 12 separator 0.9424947 ¶ 1209 1211 W4237257459.pdf 3 13 paratext 0.9809628 "Received: 16 October 2019 | Accepted: 09 January 2020 | Published: 01 February 2020" 1211 1298 W4237257459.pdf 3 14 separator 0.97744364 ¶ 1299 1301 W4237257459.pdf 3 15 title 0.77293926 References 1301 1312 W4237257459.pdf 3 16 separator 0.9820895 ¶ 1312 1314 W4237257459.pdf 3 17 bibliography 0.99795383 "Arnold, P . (1998). Sports, Ethics and education. G.B., Cassell.Cantwell, R.H. & Andrews, B. (2002). Cognitive and psychological Factors Underlying Secondary Students’ feelings Towards Group Work. Educational Psychology, 22, 75–91." 1314 1549 W4237257459.pdf 3 18 separator 0.9725154 ¶ 1549 1551 W4237257459.pdf 3 19 bibliography 0.9980212 "Darginidou, L. & Goulimaris, D. (2016). Cooperative Learning as a Preference of Adolescent Students: The Case of Dance Activities. Academic Journal of Interdisciplinary Studies, 5(3), S1." 1551 1742 W4237257459.pdf 3 20 separator 0.9634912 ¶ 1742 1744 W4237257459.pdf 3 21 bibliography 0.99809045 "Diaz, J.R. & Pintozzi, C. (1999). Helping Teams Work: Lessons Learned from the University of Arizona Library Reorganization. Library Administration and Management, 13(1), 27-36." 1744 1925 W4237257459.pdf 3 22 separator 0.9708918 ¶ 1925 1927 W4237257459.pdf 3 23 bibliography 0.99809766 "Dimas, E., Vagenas, G., & Giosos, J. (2003). The effects of dancing frequency of the parents and the place of residence on the determination of students dancing preferences. Physical Education, Sports, Health, 14(15), 15-28." 1927 2155 W4237257459.pdf 3 24 separator 0.97668916 ¶ 2155 2157 W4237257459.pdf 3 25 bibliography 0.9973734 "Doulias. E., Kosmidou, E., Pavlogiannis, O. & Patsiaouras, A. (2005). Investigate motives for participation by adolescents in traditional dance groups. Inquiries in Physical Education and Sport, 3(2), 107-112." 2157 2370 W4237257459.pdf 3 26 separator 0.9694253 ¶ 2370 2372 W4237257459.pdf 3 27 bibliography 0.9979248 "Filippou, K. & Kouthouris, X. (2014). The Role of the Camping Participation for the Development of Social Skills. Investigating Differences between Typical Camps and Camps with Outdoor Activity Programs (in Greek). Hellenic Journal of Sport & RecreationManagement, 11(1), 55-72." 2372 2654 W4237257459.pdf 3 28 separator 0.97600615 ¶ 2654 2656 W4237257459.pdf 3 29 bibliography 0.99798405 "Freeman, K.A. (1996). Attitudes toward work in project groups as predictors of academic performance. Small Group Research, 27, 265-282." 2656 2795 W4237257459.pdf 3 30 separator 0.9663591 ¶ 2795 2797 W4237257459.pdf 3 31 bibliography 0.9980638 "Gossett, M. & Fisher, O. (2005). Bringing together critical thinking and cooperative earning between two schools. Strategies. Journal of physical and sports educator, 19, 27-30." 2797 2978 W4237257459.pdf 3 32 separator 0.97655547 ¶ 2978 2980 W4237257459.pdf 3 33 bibliography 0.99808973 "Goudas, M., Hasandra, M., Papacharisis, B. & Gerodimos, B. (2006). Physical education of first grade. Teacher’s book. Athens: OEDB." 2980 3115 W4237257459.pdf 3 34 separator 0.94183666 ¶ 3115 3117 W4237257459.pdf 3 35 bibliography 0.9978186 "Gousia, B. & Kouthouris, X. (2011). 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Cd-rom, ISBN: 978-960-8373-10-5." 3612 3845 W4237257459.pdf 3 40 separator 0.97955596 ¶ 3845 3847 W4237257459.pdf 3 41 bibliography 0.99777675 "Likesas, G., Tsapakidou, A., Kostantinidou, M. & Papadopoulou, D.S. (2002). New Approaches to theaching traditional Greek dances in elementary education. Journal of Human Movement Studies, 43, 429-442." 3847 4052 W4237257459.pdf 3 42 separator 0.9661343 ¶ 4052 4054 W4237257459.pdf 3 43 bibliography 0.99800617 "Magotsiou, E. & Goudas, M. (2009). Description and Instructions for Use of the Feelings toward Group Work. Trikala: University of Thessaly. Laboratory of Exercise Psychology and Quality of Life." 4054 4252 W4237257459.pdf 3 44 separator 0.96455085 ¶ 4252 4254 W4237257459.pdf 3 45 bibliography 0.99760664 "Maisonneuve, J. (2001). Introduction to Psychosocial Studies (by N. Christakis). Athens, Typothito-Dardanos." 4254 4366 W4237257459.pdf 3 46 separator 0.95840263 ¶ 4366 4368 W4237257459.pdf 3 47 bibliography 0.9981255 "Mavrovouniotis, F.H., Argiriadou, E.A. & Papaioannou, Ch.S. (2010). Greek traditional dances and quality of old people’s life. Journal of Bodywork & Movement Therapies, 14, 209–218." 4368 4553 W4237257459.pdf 3 48 separator 0.97390175 ¶ 4553 4555 W4237257459.pdf 3 49 bibliography 0.99792725 "Mountakis, K. (2006). Physical education. Issue of training material. Ministry of Education, Athens: PI." 4555 4663 W4237257459.pdf 3 50 separator 0.95818937 ¶ 4663 4665 W4237257459.pdf 3 51 bibliography 0.9980431 "Mpougiesi, M., Zisi B., Grigoriou, S., & Pollatou, M. (2011). Greek folk dance, systematic participation affects quality of life in young and middle age adults (In Greek). Inquiries in Sport & Physical Education, 9(2), 134 - 143." 4665 4898 W4237257459.pdf 3 52 separator 0.980708 ¶ 4898 4900 W4237257459.pdf 3 53 bibliography 0.9979609 "Mpourantas, D. & Papalexandri, N. (1998). Introduction to Business Management. Athens, Benos." 4900 4997 W4237257459.pdf 3 54 separator 0.8292388 ¶ 4997 4999 W4237257459.pdf 3 55 bibliography 0.9978995 "Mpournelli, P . (2003) The Creative Dance in Education. Physical Education- Sports-Health, 14(15), 43-55." 4999 5108 W4237257459.pdf 3 56 separator 0.9690893 ¶ 5108 5110 W4237257459.pdf 3 57 bibliography 0.9979981 "Sharan, S. & Shachar, C. (1988). Language and Learning in the cooperative classroom. New York: Springer." 5110 5218 W4237257459.pdf 3 58 separator 0.8321528 ¶ 5218 5220 W4237257459.pdf 3 59 bibliography 0.99788535 "Slavin, R.E. (1987). Cooperative learning. 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Sport Psychology, 12, 61-72." 5605 5835 W4237257459.pdf 3 66 separator 0.94957274 ¶ 5835 5837 W4237257459.pdf 3 67 bibliography 0.9977854 "Zikos, G. (1992). The choreological phenomenon of the province of Vojo Kozani: pedagogical significance and educational force of the neo-ellenic dance. Unpublished PhD Thesis, EKPA, TEFAA, Athens, Greece." 5837 6045 W4237257459.pdf 3 68 separator 0.979594 ¶ 6045 6047 W4237257459.pdf 3 69 bibliography 0.99790746 Zografou, M.( 2003). Dance in Greek Tradition. Athens, ArtWork. 6047 6111 W4237257459.pdf 3 0 paratext 0.96866465 "YOSH OLIMLAR ILMIY -AMALIY KONFERENSIYASI in-academy.uz/index.php/yo 30" 0 84 W4385646277.pdf 5 1 separator 0.9864389 ¶ 86 88 W4385646277.pdf 5 2 caption 0.68536633 2-расм . 88 97 W4385646277.pdf 5 3 title 0.8357042 "Механик сариқлик билан иккала гуруҳлардаги беморларни комплекс жарроҳлик йўли билан даволаш натижалари" 97 203 W4385646277.pdf 5 4 separator 0.9941876 ¶ 205 207 W4385646277.pdf 5 5 text 0.9983024 "Шундай қилиб , ўт-тош касаллиги асорати сифатида ривожланган механик сариқликни жарроҳлик усулида комплекс даволашнинг тактик -техник жихатларини кам инвазив декомпрессив муолажаларни қўллаш ва ўт йўллари санациясини жорий қи лиш билан мақбуллаштириш холангитни эрта бартар аф этиш, жигар абсцесси пайдо бўлишини ва билиар сепсис ривожланишининг олдини олиш имконини берди . Йирингли – септик асоратларнинг 24,5% дан 12,1% гача, ўлим кўрсаткичин инг 8,2% дан 2,4% гача камайишига эришил ган." 207 723 W4385646277.pdf 5 6 separator 0.997136 ¶ 724 726 W4385646277.pdf 5 7 title 0.9886174 Хулосалар 726 736 W4385646277.pdf 5 8 separator 0.9938958 ¶ 738 740 W4385646277.pdf 5 9 text 0.9930683 "1. Ўткир йирингли холангитнинг омилли таҳлили шуни кўрсатдики, ўлим ҳолатларининг асосий сабаби бу жигар холангиоген абсцесси ва билиар сепсис ҳисобланади. Ўлим ҳолатлари (14,8%) ва йирингли -септик асоратлар (44,4%) асосан ўткир йирингли холангитни ўткир деструктив холецистит ва перитон ит билан биргаликда кечиши натижасида амалга оширилган шошилинч жарроҳлик амалиётидан кейин кузатилган. 2. Ўткир йирингли холангитни оғирлик даражаларини инобатга олган холда дастлаб ўт йўлларида декомпрессив аралашувларни қўллаш холестаз ва йирингли захарланиш ҳолатларини тўхтaтиш хамда радикал операцияларнинг натижаларини яхшилаш имконини беради. Бунда ўткир йирингли холангит билан касалланган 81,8% оғир ахволдаги, 61,6% ўрта оғирликдаги ва 24,1% енгил даражадаги беморларга диапевтик ва эндоскопик т рансдуоденал аралашувларни бажаришга эхтиёж бўлди." 740 1624 W4385646277.pdf 5 10 separator 0.6406785 1624 1625 W4385646277.pdf 5 11 text 0.96985954 . 1625 1626 W4385646277.pdf 5 12 separator 0.9843372 ¶ ¶ 1627 1633 W4385646277.pdf 5 13 paratext 0.6008292 References 1633 1645 W4385646277.pdf 5 14 bibliography 0.78695744 : 1645 1646 W4385646277.pdf 5 15 separator 0.9647001 ¶ 1647 1649 W4385646277.pdf 5 16 bibliography 0.99768525 "1. Назиров Ф.Г., Акилов Х.А., Акбаров М.М. Тактика лечения больных с механической желтухой, осложненной холангитом и печеночной недостаточностью // Анналы хирургической гепатологии. – 2011. No2. С. – 117 -118." 1649 1865 W4385646277.pdf 5 17 separator 0.7031806 ¶ 1867 1869 W4385646277.pdf 5 18 bibliography 0.99432945 "2. Хаджибаев А.М. Малоинвазивные вмешательства при остром холецистите, осложнённом механической желтухой у больных пожилого и старческого возра ста / А.М. Хаджибаев, Ш.К. Атаджанов, Б.Б. Хакимов // Вестник хирургии. – 2017. – N 3. – С. 66 - " 1869 2117 W4385646277.pdf 5 19 separator 0.49897346 ¶ 2117 2118 W4385646277.pdf 5 20 bibliography 0.8927807 68. 2118 2122 W4385646277.pdf 5 21 table 0.9948182 "24,50% 12,10% 8,20% 2,40% 0,00%5,00%10,00%15,00%20,00%25,00%30,00%" 2122 2197 W4385646277.pdf 5 22 separator 0.91111493 ¶ 2197 2199 W4385646277.pdf 5 23 table 0.93287385 "Таққослаш гурухи Асосий гурухЖаррохлик амалиётидан кейинги асоратлар Леталлик" 2199 2285 W4385646277.pdf 5 0 paratext 0.9877166 Healthcare 2021 ,9, 1115 10 of 20 0 33 W3198686690.pdf 9 1 separator 0.9868662 ¶ 33 35 W3198686690.pdf 9 2 title 0.99235004 2.3. Ranking Test 35 53 W3198686690.pdf 9 3 separator 0.9943906 ¶ 53 55 W3198686690.pdf 9 4 text 0.99938345 "In the first phase of the experiment, participants were tasked to rank COVID-19 preventive measure icons within the same function name. Following Chi and Dewi [ 4], the experiment was administered with a computer program developed using JavaScript and PHP software where respondents ranked the displayed icons from 1 to 7 (See Figure 2 )." 55 399 W3198686690.pdf 9 5 separator 0.6577903 ¶ 399 401 W3198686690.pdf 9 6 text 0.9988747 "Each participant would rank the most preferred icon under a function name as 1; the next preferred would be ranked as 2, and so on. Thus, the least favored icon was ranked as 7. The icons were laid out in a circular manner to avoid possible sequence effect [ 31,32] or location bias [ 33]. The function names were also stated next to the displayed icon to provide appropriate context and description for each function [ 34]. The experiment was conducted online." 401 873 W3198686690.pdf 9 7 separator 0.9900196 ¶ 873 875 W3198686690.pdf 9 8 paratext 0.98813003 Healthcare 2021 , 9, x 11 of 21 875 908 W3198686690.pdf 9 9 separator 0.96215934 ¶ ¶ 909 915 W3198686690.pdf 9 10 title 0.9932068 2.3. Ranking Test 916 934 W3198686690.pdf 9 11 separator 0.99471986 ¶ 935 937 W3198686690.pdf 9 12 text 0.9995835 "In the first phase of the experiment, partic ipants were tasked to rank COVID-19 pre- ventive measure icons within the same function name. Following Chi and Dewi [4], the experiment was administered with a computer program developed using JavaScript and PHP software where respondents ranked the displayed icons from 1 to 7 (See Figure 2)." 937 1284 W3198686690.pdf 9 13 separator 0.7869074 ¶ 1285 1287 W3198686690.pdf 9 14 text 0.9933345 "Each participant would rank the most preferred icon under a function name as 1; the next preferred would be ranked as 2, and so on. Thus, the least favored icon was ranked as 7. The icons were laid out in a circular manner to avoid possible sequence effect [31,32] or location bias [33]. The function names were al so stated next to the displayed icon to pro- vide appropriate context and description for ea ch function [34]. The experiment was con- ducted online." 1287 1762 W3198686690.pdf 9 15 separator 0.9929207 ¶ ¶ 1763 1769 W3198686690.pdf 9 16 caption 0.98897237 Figure 2. Example of ranking test screen. 1769 1811 W3198686690.pdf 9 17 separator 0.9948613 ¶ 1812 1814 W3198686690.pdf 9 18 title 0.9933851 2.4. Subjective Rating Test 1814 1842 W3198686690.pdf 9 19 separator 0.9946135 ¶ 1843 1845 W3198686690.pdf 9 20 text 0.99958557 "According to Liu and Ho [35], subjective ra ting features are reliable in determining the performance of icons based on recognitio n accuracy [35]. Addi tionally, subjective scales are easy to administer since they are more sensitive than objective measurements [36]. Therefore, in this phase of the experiment , participants were asked to rate their top 2 icons from the ranking test (i.e., icons with fir st and second rank for each function) on the basis of subjective design features such as perceived icon quality, communicativeness [21], layout [21], and complexity and semantic distance [4,19,20], as defined in Table 4. Follow-ing Chi et al. [37], semantic scales were then assigned for each of the subjective design features (Table 5)." 1845 2612 W3198686690.pdf 9 21 separator 0.99703026 ¶ 2613 2615 W3198686690.pdf 9 22 title 0.94188136 Table 4. Descriptions of subjective design features. 2615 2668 W3198686690.pdf 9 23 separator 0.99173033 ¶ 2669 2671 W3198686690.pdf 9 24 title 0.87820387 Subjective Design Features Definition 2671 2709 W3198686690.pdf 9 25 separator 0.89426064 ¶ 2710 2712 W3198686690.pdf 9 26 text 0.9802997 "Perceived Icon Quality One of the most critical aspects of icon development that defines the successful design [38]" 2712 2832 W3198686690.pdf 9 27 separator 0.5550918 ¶ 2833 2835 W3198686690.pdf 9 28 text 0.95289147 "Communicativeness Refers to how the icon expresses its intended meaning [21]. Complexity Pertains to how complex the details intricated on the icon are [19]. Layout How carefully the features of an icon are arranged [21]. Semantic Distance The measure of the closeness of what is illustrated in the icon to its true intended meaning [20]." 2835 3190 W3198686690.pdf 9 29 separator 0.99330235 ¶ 3191 3193 W3198686690.pdf 9 30 caption 0.98843056 Figure 2. Example of ranking test screen. 3193 3235 W3198686690.pdf 9 31 separator 0.99402547 ¶ 3235 3237 W3198686690.pdf 9 32 title 0.9933178 2.4. Subjective Rating Test 3237 3265 W3198686690.pdf 9 33 separator 0.9951413 ¶ 3265 3267 W3198686690.pdf 9 34 text 0.9969876 "According to Liu and Ho [ 35], subjective rating features are reliable in determining the performance of icons based on recognition accuracy [ 35]. Additionally, subjective scales are easy to administer since they are more sensitive than objective measurements [ 36]. Therefore, in this phase of the experiment, participants were asked to rate their top 2 icons from the ranking test (i.e., icons with first and second rank for each function) on the basis of subjective design features such as perceived icon quality, communicativeness [ 21], layout [ 21], and complexity and semantic distance [ 4,19,20], as defined in Table 4. Following Chi et al. [ 37], semantic scales were then assigned for each of the subjective design features (Table 5)." 3267 4027 W3198686690.pdf 9 35 separator 0.9829678 ¶ 4027 4029 W3198686690.pdf 9 36 text 0.9971315 "The respondents’ top two icons were shown one by one and they were instructed to evaluate the appearance of each icon according to the semantic scales (Figure 3). They were made aware that on the 7-point Likert scale, the closer they choose to the left or right semantic scale, the better they think that the icon displayed fits the semantic scale. However, if they choose the middle of the scale, their opinion of the icon fits both semantic scales. Similar to the ranking test, the test on subjective design features was also developed using JavaScript and PHP software and conducted online." 4029 4633 W3198686690.pdf 9 0 paratext 0.9752991 18 0 2 W4381571467.pdf 13 1 separator 0.68351877 ¶ 2 4 W4381571467.pdf 13 2 title 0.57760555 Acta Politica Polo 4 23 W4381571467.pdf 13 3 paratext 0.4940114 nica 23 27 W4381571467.pdf 13 4 title 0.52657765 Ja 27 29 W4381571467.pdf 13 5 paratext 0.5404536 cek 29 32 W4381571467.pdf 13 6 title 0.5811458 Wezgraj 32 40 W4381571467.pdf 13 7 separator 0.99406266 ¶ 42 44 W4381571467.pdf 13 8 text 0.99972934 "Prawicy osoby zdrowe, młode, dość zamożne, w przeważającej części płci męskiej. Oznacza to, że obecna sytuacja jest wynikiem ich świadomego wyboru niepodyktowanego prześladowaniem czy zagrożeniem życia, lecz nisko cenionym osobistym interesem ekonomicznym. Nie trzeba im w związku z tym współczuć, co najwyżej oburzać się na to, jakie decyzje podjęli i jak stali się bronią w toczonej z Polską wojnie hybrydowej. O współczuciu, trosce, empatii, kierowaniu się sercem mówią politycy opozycji, co w kontekście całości analizowanego tutaj dyskursu medialnego raczej ustawia ich na pozycji osób naiwnych, „miękkich” i niedostrzegających oczywistego zagrożenia." 44 720 W4381571467.pdf 13 9 separator 0.9828507 ¶ 720 722 W4381571467.pdf 13 10 text 0.9997694 "Unia Europejska – co może być dość zaskakujące, jak na medium definiujące się jako głos konserwatystów – przedstawiana jest jako sojusznik Polski. Obrona granic RP jest jednocześnie chronieniem zewnętrznych granic UE, co pozwala na zaprezentowanie rządu polskiego jako gwaranta bezpieczeństwa całej Europy Zachodniej. W tym kontekście przywoływany jest kryzys uchodźczy z roku 2015, co pozwala na pokazanie przenikliwości polityków Prawa i Sprawiedliwo - ści. Unia Europejska miała wtedy popełnić błąd polegający na przyjmowaniu uchodźców, co wpły - nęło na życie obywateli państw w jej skład wchodzących, lecz na szczęście „zreflektowała się” i teraz wspiera politykę tych, którzy wtedy stosowali retorykę antyuchodźczą." 722 1467 W4381571467.pdf 13 11 separator 0.9964026 ¶ 1467 1469 W4381571467.pdf 13 12 title 0.98771125 Podsumowanie 1469 1482 W4381571467.pdf 13 13 separator 0.9964595 ¶ 1482 1484 W4381571467.pdf 13 14 text 0.99976134 "W analizie dyskursu medialnego wskazano na przedstawianie kryzysu jako elementu wojny hybrydowej prowadzonej przeciwko Polsce przez Białoruś. Co interesujące przeciwnikiem władz polskich jest nie tylko prezydent Białorusi, lecz również opozycja oraz media niezwiązane z władzą." 1484 1768 W4381571467.pdf 13 15 separator 0.91366607 ¶ 1769 1771 W4381571467.pdf 13 16 text 0.9997559 "Dramatyczna sytuacja osób koczujących w lasach przy polskiej granicy schodzi zaś na dalszy plan z uwagi na sposoby rozumienia bezpieczeństwa, potencjalnych zagrożeń dla Polski oraz jej interesów. Wskazano zatem na obecność elementów dyskursu nacjonalistycznego w analizowa - nym materiale." 1771 2069 W4381571467.pdf 13 17 separator 0.9815634 ¶ 2069 2071 W4381571467.pdf 13 18 text 0.99966896 "Pod koniec sierpnia 2021 roku sondaż przeprowadzony dla RMF FM oraz Dziennik. Gazeta Prawna wykazał, że 45,4% ankietowanych popiera działania władz polskich dotyczących sytu - acji na granicy. Negatywne zdanie na ten temat miało 42,4% badanych. 36,9% respondentów opowiedziało się za przyjmowaniem osób starających się o azyl, po weryfikacji przez służby, zaś 25% stanowczo opowiada się za odmową przyjęcia kogokolwiek ( Co Polacy sądzą ..., 2021)." 2071 2530 W4381571467.pdf 13 19 separator 0.9746953 ¶ 2531 2533 W4381571467.pdf 13 20 text 0.9995761 "Wyniki te wskazują na konieczność dalszych analiz dyskursu medialnego i jego wpływu na odbior - ców różnych mediów. Warto zbadać podobieństwa, a przede wszystkim różnice w przedstawianiu kryzysu w Usnarzu, w relacjach mediów niewspierających obozu rządzącego." 2533 2798 W4381571467.pdf 13 21 separator 0.9504832 ¶ 2798 2800 W4381571467.pdf 13 22 text 0.9995104 "W niniejszym artykule nie wyczerpano tematu − problematykę dyskursu medialnego zwią - zanego z kryzysem granicznym ograniczono do jednego portalu, wraz z jego specyfiką i kontek - stem funkcjonowania oraz nastawieniem do rządów zjednoczonej prawicy. Dlatego uogólnianie płynących z niego wniosków może być ryzykowne. Analizy innych przekazów medialnych reprezentujących nurt konserwatywny, mogą zatem być zatem odmienne." 2800 3232 W4381571467.pdf 13 0 paratext 0.90445226 "OLIVEIRA ET AL. (2013 ) ¶ HOLOS, Ano 29, Vol 4 4" 0 60 W2020679911.pdf 1 1 separator 0.58402663 ¶ ¶ 61 67 W2020679911.pdf 1 2 title 0.97659874 ROCHAS ORNAMENTAIS SILICÁTICAS DO ESTADO DE PERNAMBUCO 67 122 W2020679911.pdf 1 3 separator 0.97651684 ¶ ¶ 124 130 W2020679911.pdf 1 4 title 0.9896215 1. INTRODUÇÃO 130 144 W2020679911.pdf 1 5 separator 0.9918326 ¶ ¶ 146 152 W2020679911.pdf 1 6 title 0.9885793 1.1. ROCHAS ORNAMENTAIS 152 176 W2020679911.pdf 1 7 separator 0.9945928 ¶ 178 180 W2020679911.pdf 1 8 text 0.99971616 "As rochas ornamentais e de revestimento, também chamadas pedras naturais, rochas lapídeas e rochas dimensionais, são materiais que agregam valor principalmente através de suas características estéticas, destacando -se o padrão cromático, desenho, textura e granulação. Os materiais naturais de ornamentação e revestimento abrangem as rochas que são extraídas em blocos ou placas, cortadas em formas variadas e têm suas faces beneficiadas através de esquadrejamento, polimento, lustro apicoamento e flamejamento. A s principais rochas utilizadas incluem mármores, travertinos, granitos, ardósias, quartzitos, pedra sabão, etc. (CHIODI, 2001)." 180 840 W2020679911.pdf 1 9 separator 0.81955755 ¶ 842 844 W2020679911.pdf 1 10 text 0.99960226 "Os “granitos” correspondem cientificamente às rochas ígneas e metamórficas de granulometria grossa compostas principalmente de m inerais félsicos. Enquanto os mármores resultam do metamorfismo de calcários e dolomitos. O padrão cromático é definido por minerais acessórios e impurezas. Quartzitos e arenitos são rochas compostas essencialmente por quartzo." 844 1210 W2020679911.pdf 1 11 separator 0.76901364 ¶ 1211 1213 W2020679911.pdf 1 12 text 0.99963593 "Geralmente, arenitos são roc has sedimentares clásticas (originadas do acúmulo e consolidação de sedimentos de granulação areia: 0,02 a 2,0 mm), enquanto os quartzitos originam –se a partir de metamorfismo de rochas sedimentares. Conglomerados são também rochas sedimentares clásticas, (superior a 2,0 mm). Acham -se afetados por metamorfismo, o que lhes confere maior coesão entre os grãos e maior resistência mecânica. As “ardósias” compõem -se essencialmente de mica (muscovita - sericita), quartzo e clorita. São de baixo valor comercial se ndo tratadas como rochas semi ornamentais ." 1213 1821 W2020679911.pdf 1 13 separator 0.95066106 ¶ 1822 1824 W2020679911.pdf 1 14 text 0.99936473 "O uso e aplicação das rochas ornamentais e de revestimento baseiam -se no conhecimento de suas propriedades físicas e mecânicas, na sua composição mineralógica, textura, grau de microfissuramento e porosidade. Do m esmo modo, as informações sobre o ambiente no qual a rocha será aplicada influencia sobre a decisão da escolha da mesma: ambientes quentes e úmidos são natur almente mais propícios para a alteração dos minerais constituintes da rocha; regiões de climas seco s e quentes induzem a ciclos de dilatação/contração, o que finda por quebrar a rocha; locais de grande circulação de pessoas tais como saguões de aeroportos, centro de compras, supermercados requerem litotipos cujos constituintes mineralógicos apresentem d ureza elevada. Frazão & Farjallat (1996) indicam valores dos índices físicos e características mecânicas que devem ser observados para o melhor desempenho do material ornamental." 1824 2764 W2020679911.pdf 1 15 separator 0.98980224 ¶ ¶ 2766 2772 W2020679911.pdf 1 16 title 0.9939644 1.2. ROCHAS ORNAMENTAIS SILICÁTICAS DO BRASIL 2772 2818 W2020679911.pdf 1 17 separator 0.9926941 ¶ ¶ 2820 2826 W2020679911.pdf 1 18 text 0.99958366 "A produção das rochas ornamen tais apresentou crescimento acelerado nas últimas décadas, sendo estas utilizadas em ambientes externos de prédios, pisos, paredes, mesas e pias." 2826 3005 W2020679911.pdf 1 19 separator 0.56303626 ¶ 3007 3009 W2020679911.pdf 1 20 text 0.9994824 "No país a produção nacional de mármores iniciou -se no sul do Estado de Minas Gerais, no município do Mar de Es panha, em 1908. Conseguindo cobrir 73% do consumo nacional, em 1938." 3009 3193 W2020679911.pdf 1 21 separator 0.57340044 ¶ 3194 3196 W2020679911.pdf 1 22 text 0.99959356 "Até a primeira metade do Século XX, os mármores foram mais utilizados para usos ornamentais altamente decorativos, portanto, as lojas que trabalham com rochas ornamentais são denominadas, até o presente, ""marmoraria"". O uso dos “granitos” como material de acabamento decorativo iniciou -se na década de 1950, só sendo possível devido ao evento das serras" 3196 3561 W2020679911.pdf 1 0 paratext 0.987232 Land 2022 ,11, 651 19 of 19 0 27 W4225141055.pdf 18 1 separator 0.99149215 ¶ 27 29 W4225141055.pdf 18 2 bibliography 0.99776614 "33. Badia, A.; Serra, P .; Modugno, S. Identifying dynamics of fire ignition probabilities in two representative Mediterranean wildland-urban interface areas. Appl. Geogr. 2011 ,31, 930–940. [CrossRef]" 29 232 W4225141055.pdf 18 3 separator 0.9212148 ¶ 232 234 W4225141055.pdf 18 4 bibliography 0.99797684 "34. Vilar, L.; Woolford, D.; Martell, D.; Mart ín, M. A model for predicting human-caused wildfire occurrence in the region of Madrid, Spain. Int. J. Wildland Fire 2010 ,19, 325–337. [CrossRef]" 234 429 W4225141055.pdf 18 5 separator 0.9422473 ¶ 429 431 W4225141055.pdf 18 6 bibliography 0.99803746 "35. Dickson, B.G.; Prather, J.W.; Xu, Y.; Hampton, H.M.; Aumack, E.N.; Sisk, T.D. Mapping the probability of large fire occurrence in northern Arizona, USA. Landsc. Ecol. 2006 ,21, 747–761. [CrossRef]" 431 633 W4225141055.pdf 18 7 separator 0.93049896 ¶ 633 635 W4225141055.pdf 18 8 bibliography 0.9977369 "36. Nunes, A.N. Regional variability and driving forces behind forest fires in Portugal an overview of the last three decades (1980–2009). Appl. Geogr. 2012 ,34, 576–586. [CrossRef]" 635 818 W4225141055.pdf 18 9 separator 0.94503295 ¶ 818 820 W4225141055.pdf 18 10 bibliography 0.9978982 "37. Riley, S.; Degloria, S.; Elliot, S.D. A Terrain Ruggedness Index That Quantifies Topographic Heterogeneity. Int. J. Sci. 1999 ,5, 23–27." 820 962 W4225141055.pdf 18 11 separator 0.9636861 ¶ 962 964 W4225141055.pdf 18 12 bibliography 0.99802935 38. Aitchison, J. The Statistical Analysis of Compositional Data. J. R. Stat. Soc. Ser. B 1982 ,44, 139–177. [CrossRef] 964 1084 W4225141055.pdf 18 13 separator 0.9179734 ¶ 1084 1086 W4225141055.pdf 18 14 bibliography 0.98786795 "39. Chen, J.; Zhang, X.; Li, S. Multiple linear regression with compositional response and covariates. J. Appl. Stat. 2017 ,44, 2270–2285. [CrossRef]" 1086 1238 W4225141055.pdf 18 15 separator 0.9660412 ¶ 1238 1240 W4225141055.pdf 18 16 bibliography 0.99801576 "40. van den Boogaart, K.G.; Filzmoser, P .; Hron, K.; Templ, M.; Tolosana-Delgado, R. Classical and Robust Regression Analysis with Compositional Data. Math. Geosci. 2021 ,53, 823–858. [CrossRef]" 1240 1438 W4225141055.pdf 18 17 separator 0.94375163 ¶ 1438 1440 W4225141055.pdf 18 18 bibliography 0.9978896 "41. Corsmeier, U.; Kalthoff, N.; Barthlott, C.; Aoshima, F.; Behrendt, A.; Di Girolamo, P .; Dorninger, M.; Handwerker, J.; Kottmeier, C.; Mahlke, H.; et al. Processes driving deep convection over complex terrain: A multi-scale analysis of observations from COPS IOP 9c.Q. J. R. Meteorol. Soc. 2011 ,137, 137–155. [CrossRef]" 1440 1769 W4225141055.pdf 18 19 separator 0.965641 ¶ 1769 1771 W4225141055.pdf 18 20 bibliography 0.9930137 "42. Harrison, S.P .; Prentice, I.C.; Bloomfield, K.J.; Dong, N.; Forkel, M.; Forrest, M.; Ningthoujam, R.K.; Pellegrini, A.; Shen, Y.; Baudena, M.; et al. Understanding and modelling wildfire regimes: An ecological perspective. Environ. Res. Lett. 2021 ,16, 125008. [CrossRef]" 1771 2050 W4225141055.pdf 18 21 separator 0.9673867 ¶ 2050 2052 W4225141055.pdf 18 22 bibliography 0.9979251 "43. Conedera, M.; Cesti, G.; Pezzatti, G.B.; Zumbrunnen, T.; Spinedi, F. Lightning-induced fires in the Alpine region: An increasing problem. For. Ecol. Manag. 2006 ,234, S68. [CrossRef]" 2052 2240 W4225141055.pdf 18 23 separator 0.9603837 ¶ 2240 2242 W4225141055.pdf 18 24 bibliography 0.9979525 "44. Fernandez-Anez, N.; Krasovskiy, A.; Müller, M.; Vacik, H.; Baetens, J.; Huki ́ c, E.; Kapovic Solomun, M.; Atanassova, I.; Glushkova, M.; Bogunovi ́ c, I.; et al. Current Wildland Fire Patterns and Challenges in Europe: A Synthesis of National Perspectives. Air Soil Water Res. 2021 ,14, 11786221211028185. [CrossRef]" 2242 2566 W4225141055.pdf 18 25 separator 0.9678046 ¶ 2566 2568 W4225141055.pdf 18 26 bibliography 0.99806595 "45. Jones, M.W.; Abatzoglou, J.T.; Veraverbeke, S.; Andela, N.; Lasslop, G.; Forkel, M.; Smith, A.J.P .; Burton, C.; Betts, R.A.; van der Werf, G.R.; et al. Global and regional trends and drivers of fire under climate change. Rev. Geophys. 2022 ,60, e2020RG000726." 2568 2834 W4225141055.pdf 18 27 separator 0.8976979 ¶ 2834 2836 W4225141055.pdf 18 28 bibliography 0.9964153 [CrossRef] 2836 2847 W4225141055.pdf 18 0 paratext 0.8966116 Page 13/1421. 0 13 W4226075124.pdf 12 1 bibliography 0.99697846 "Donaldson JF, Lardas M, Scrimgeour D, Stewart F, MacLennan S, Lam TB, et al. Systematic review and meta-analysis of the clinical effectiveness of shock wave lithotripsy, retrograde intrarenal surgery, and percutaneous nephrolithotomy for lower-pole renal stones. Eur Urol. 2015; doi:10.1016/j.eururo.2014.09.054." 13 332 W4226075124.pdf 12 2 separator 0.98412585 ¶ 332 334 W4226075124.pdf 12 3 bibliography 0.9978156 "22. Kang SK, Cho KS, Kang DH, Jung HD, Kwon JK, Lee JY. Systematic review and meta-analysis to compare success rates of retrograde intrarenal surgery versus percutaneous nephrolithotomy for renal stones >2 cm: An update. Medicine (Baltimore). 2017; doi:10.1097/MD.0000000000009119." 334 620 W4226075124.pdf 12 4 separator 0.9824604 ¶ 620 622 W4226075124.pdf 12 5 bibliography 0.98219776 "23. Cracco CM, Scoffone CM. ECIRS (Endoscopic Combined IntraRenal Surgery) in the Galdakao- modi" 622 721 W4226075124.pdf 12 0 caption 0.9750075 SupplementaryFigure1.MicrobiologicalexaminationsinThinPrepcytologicaltests 0 74 W4307183737.pdf 0 1 separator 0.98473275 ¶ 74 76 W4307183737.pdf 0 2 caption 0.9802641 smears(Papstain400×) 76 97 W4307183737.pdf 0 3 separator 0.9469601 ¶ 97 99 W4307183737.pdf 0 4 text 0.91874045 "(A)BV:commonbacteriaincytologysmear;(B)VVC:Candidaincytologysmear; (C)KoilocytesincytologysmearindicateHPVinfection." 99 218 W4307183737.pdf 0 0 title 0.8357091 "Intelligent methods for optimization design of lightweight fiber-reinforced composite structures: A review andthe-state-of-the-art" 0 135 W4362475876.pdf 0 1 separator 0.9922529 ¶ 135 137 W4362475876.pdf 0 2 contact 0.840563 "Yonglin Chen1, Junming Zhang1, Zefu Li1, Huliang Zhang1, Jiping Chen1,2, Weidong Yang1*, Tao Yu1, Weiping Liu2and Yan Li1*" 137 264 W4362475876.pdf 0 3 separator 0.927115 ¶ 264 266 W4362475876.pdf 0 4 contact 0.9870447 "1School of Aerospace Engineering and Applied Mechanics, Tongji University, Shanghai, China,2COMAC Shanghai Aircraft Manufacturing Co., Ltd., Shanghai, China" 266 425 W4362475876.pdf 0 5 separator 0.9937124 ¶ 425 427 W4362475876.pdf 0 6 text 0.99949545 "As the application of lightweight fiber-reinforced composite structures reaches an unprecedented scale in industry, design technology for composite structuresbecomes crucial for enhancing performance, improving productivity, andreducing cost. In recent years, the rapid development of intelligent technology, such as big data, deep learning, and machine learning, has promoted the development of design technology. However, the current situation andintellectualization of the design technology is not well summarized. This paperreviews the advance in design technologies for fiber-reinforced composite structures, including prediction and optimization methods for compositeproperties. Then, their intellectualization development is overviewed. Finally,the development trend of intelligent design technologies and intelligentcomposite structures are discussed. This work can provide a reference for researchers in the related field." 427 1366 W4362475876.pdf 0 7 separator 0.99646527 ¶ 1366 1368 W4362475876.pdf 0 8 title 0.95542693 KEYWORDS 1368 1377 W4362475876.pdf 0 9 separator 0.988502 ¶ 1377 1379 W4362475876.pdf 0 10 text 0.56266415 "lightweight fiber-reinforced composite structure, intelligent prediction, optimization design, intellectualization, multiscale" 1379 1507 W4362475876.pdf 0 11 separator 0.99559736 ¶ 1507 1509 W4362475876.pdf 0 12 title 0.97927004 1 Introduction 1509 1524 W4362475876.pdf 0 13 separator 0.99482507 ¶ 1524 1526 W4362475876.pdf 0 14 text 0.9914427 "Lightweight fiber-reinforced polymer (FRP) composite has been widely used in aerospace industry due to its high strength-weight ratio, high temperature resistance, outstanding designability to meet different requirements and the ability to integrate large-scale integral structures ( Zhao et al., 2016 ;Sun et al., 2020 ;Wang et al., 2021a ; Wang et al., 2021b ). As shown in Figure 1A , the application of lightweight FRP composite in aircraft has been increasing rapidly since the end of 20th century. The composite structureweights of Boeing 787 ( Figure 1B (DOCSLIB, 2022 )) and Airbus A350, most advanced commercial aircraft in the world, are over 50%. The application of FRP not only enhancestheir safety and energy-ef ficient signi ficantly, but also is environment-friend ( Van Grootel et al., 2020 ). Because of the bene fits, the usage of FRP composite in aerospace industry will increase continuously. The mechanical properties of FRP composite in aircraft, such as engine and wing, mainly depend on both the design and manufacturing technologies ( Figure 2 )." 1526 2614 W4362475876.pdf 0 15 paratext 0.9177303 OPEN ACCESS 2614 2625 W4362475876.pdf 0 16 separator 0.98725355 ¶ 2625 2627 W4362475876.pdf 0 17 contact 0.98119515 "EDITED BY Christophe Binetruy, Ecole Centrale de Nantes, France REVIEWED BY Fethi Abbassi,American University of the Middle East,KuwaitAdnan Kefal, Sabanc ıUniversity, Türkiye" 2627 2813 W4362475876.pdf 0 18 separator 0.5197495 ¶ 2813 2815 W4362475876.pdf 0 19 contact 0.9968128 "*CORRESPONDENCE Weidong Yang, 20501@tongji.edu.cn Yan Li, liyan@tongji.edu.cn" 2815 2901 W4362475876.pdf 0 20 separator 0.98889565 ¶ 2901 2903 W4362475876.pdf 0 21 title 0.83174014 SPECIALTY SECTION 2903 2921 W4362475876.pdf 0 22 separator 0.7458592 ¶ 2921 2923 W4362475876.pdf 0 23 paratext 0.64244854 This article was submitted to Poly 2923 2958 W4362475876.pdf 0 24 text 0.46308357 meric 2958 2963 W4362475876.pdf 0 25 paratext 0.77835053 "and Composite Materials,a section of the journalFrontiers in Materials RECEIVED 16 December 2022 ACCEPTED 14 March 2023 PUBLISHED 31 March 2023" 2963 3112 W4362475876.pdf 0 26 separator 0.9906632 ¶ 3112 3114 W4362475876.pdf 0 27 title 0.6884961 CITATION 3114 3123 W4362475876.pdf 0 28 separator 0.99097705 ¶ 3123 3125 W4362475876.pdf 0 29 bibliography 0.9253567 "Chen Y, Zhang J, Li Z, Zhang H, Chen J,Yang W, Yu T, Liu W and Li Y (2023),Intelligent methods for optimizationdesign of lightweight fiber-reinforced composite structures: A review and the-state-of-the-art.Front. Mater. 10:1125328. doi: 10.3389/fmats.2023." 3125 3385 W4362475876.pdf 0 30 paratext 0.5933162 1125328 3385 3392 W4362475876.pdf 0 31 separator 0.9803221 ¶ 3392 3394 W4362475876.pdf 0 32 paratext 0.82744634 "COPYRIGHT © 2023 Chen," 3394 3419 W4362475876.pdf 0 33 bibliography 0.82055795 "Zhang, Li, Zhang, Chen, Yang, Yu, Liu and Li" 3419 3466 W4362475876.pdf 0 34 paratext 0.957552 ". This is an open-access article distributed under the termsof the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums ispermitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in thisjournal is cited, in accordance withaccepted academic practice. No use,distribution or reproduction is permittedwhich does not comply with these terms." 3466 3919 W4362475876.pdf 0 35 separator 0.48497608 3919 3920 W4362475876.pdf 0 36 paratext 0.94452256 "¶ Frontiers in Materials frontiersin.org 01TYPE Review PUBLISHED 31 March 2023 DOI10.3389/fmats.2023.1125328" 3920 4032 W4362475876.pdf 0 0 paratext 0.9846166 732 Jurnal Teknik Pertanian Lampung Vol 12, No. 3 (2023) : 721 -737 0 67 W4386442137.pdf 11 1 separator 0.9739283 ¶ ¶ 68 74 W4386442137.pdf 11 2 title 0.9904515 3.2.5 Vitamin C 74 90 W4386442137.pdf 11 3 separator 0.99518776 ¶ 92 94 W4386442137.pdf 11 4 text 0.99953794 "The results of the analysis showed that the degreening treatment and storage temperature had no significant effect on the vitamin C of Gerga Pagar Alam oranges on day 0, but it was significant on the observations on days 14 and 29, where there was an interaction between the two treatments (Table 6). In general, the content of vitamin C in oranges during storage decreased. According to Hasmini (2017) the decrease in vitamin C content (ascorbic acid) occurs due to the degradation of vitamin C during storage. From the research results, the vitamin C content of Gerga Pagar Alam oranges decreased during storage (Table 6). On day 0 the vitamin C content reached 57.85 mg/100g then decreased by 33.64 – 40 mg/100g (Table 6). This is in accordance with research by Hasimi et al . (2016) , the content of vitamin C in Siamese oranges ranges from 34.32 – 48.50 mg/100g. In the study by Mikasari et al . (2015) the vitamin C content of RGL oranges was 46 mg/100g. Table 10 shows the interaction effect of degreening and storage temperature on the vitamin C on the 29th day." 94 1204 W4386442137.pdf 11 5 separator 0.98855555 ¶ ¶ 1206 1212 W4386442137.pdf 11 6 title 0.7133887 Table 6. Effect of degreening and storage temperature on vitamin C (mg/100g) in 1212 1294 W4386442137.pdf 11 7 table 0.5779203 ¶ 1295 1297 W4386442137.pdf 11 8 title 0.5665926 Gerga Pagar Alam oranges 1297 1322 W4386442137.pdf 11 9 table 0.45958316 during storage 1322 1337 W4386442137.pdf 11 10 separator 0.9810651 ¶ ¶ 1339 1345 W4386442137.pdf 11 11 title 0.91421276 "Table 7. Interaction of degreening and storage temperature of vitamin C in Gerga Pagar Alam oranges on the 29th day of observation" 1345 1480 W4386442137.pdf 11 12 separator 0.9869108 ¶ ¶ 1482 1488 W4386442137.pdf 11 13 text 0.99945545 "From the DMRT test results on the interaction of degreening and storage temperature on the 29th day of observation, it showed that the highest vitamin C content was in the combination of degreening 250 ppm at 20 °C and not significantly different from degreening 0 ppm at a temperature of 20 °C, this shows the combination of degreening 250 ppm and temperature 20 °C can maintain the Vitamin C content of Gerga Pagar Alam oranges." 1488 1934 W4386442137.pdf 11 14 table 0.97912633 Treatment 0 1935 1949 W4386442137.pdf 11 15 paratext 0.8172722 14 29 1949 1955 W4386442137.pdf 11 16 separator 0.592899 1956 1957 W4386442137.pdf 11 17 table 0.9889237 "¶ Degreening 0 ppm 57,85 ± 3,26 52,68 ± 7,12c 36,73 ± 3,98b 250 ppm 57,85 ± 3,26 44,51 ± 3,80a 36,45 ± 4,25b 500 ppm 57,85 ± 3,26 46,18 ± 3,95b 36,09 ± 1,13b 750 ppm 57,85 ± 3,26 57,22 ±15,23d 35,07 ± 4,0a Temperature Room 57,85 ± 3,26 49,67 ± 9,22a 34,44 ± 1,42b 10oC 57,85 ± 3,26 51,63 ± 12,30c 33,64 ± 2,12a 20oC 57,85 ± 3,26 49,15 ± 8,51a 40,18 ± 2,08c Interaction tn * *" 1957 2408 W4386442137.pdf 11 18 separator 0.7037277 ¶ 2409 2411 W4386442137.pdf 11 19 text 0.77874094 "Note: numbers followed by the same letters in the same column are not significantly different at the 5% DMRT test level, tn = not significantly different, * = significantly different at the 5% level" 2411 2613 W4386442137.pdf 11 20 separator 0.96937454 ¶ 2615 2617 W4386442137.pdf 11 21 table 0.9951286 "Degreening Treatment Storage temperature TR T10 T20 0 ppm 35,11 ± 1,18c 33,22 ± 0,45b 41,86 ± 0,33f 250 ppm 32,50 ± 0,23b 34,92 ± 0,45c 41,93 ± 0,53f 500 ppm 35,26 ± 1,42c 35,82 ± 0,39c 37,18 ± 0,17d 750 ppm 34,88 ± 0,17c 30,58 ± 0,58a 39,75 ± 0,90e" 2617 2899 W4386442137.pdf 11 22 separator 0.7822765 ¶ 2901 2903 W4386442137.pdf 11 23 text 0.6178143 Note: numbers followed by the same letters in the same column are not 2903 2973 W4386442137.pdf 11 24 table 0.49151155 2973 2974 W4386442137.pdf 11 25 text 0.5301068 significantly different at the 5% DMRT test ¶ 2974 3020 W4386442137.pdf 11 26 table 0.44180852 level 3020 3026 W4386442137.pdf 11 0 paratext 0.9841384 RESEARCH ARTICLE Open Access 0 28 W2947789980.pdf 0 1 separator 0.90943956 ¶ 28 30 W2947789980.pdf 0 2 title 0.956637 "Glucocorticoids promote the development of azoxymethane and dextran sulfate sodium-induced colorectal carcinoma in mice" 30 156 W2947789980.pdf 0 3 separator 0.9875255 ¶ 156 158 W2947789980.pdf 0 4 contact 0.67859054 Bo Li1,2†, Yan Wang1†, Lijuan Yin3, Gaoxiang Huang1,Y iX u3, Jie Su1, Liye Ma2and Jian Lu1* 158 250 W2947789980.pdf 0 5 separator 0.995162 ¶ 250 252 W2947789980.pdf 0 6 title 0.9379098 Abstract 252 261 W2947789980.pdf 0 7 separator 0.993376 ¶ 261 263 W2947789980.pdf 0 8 text 0.9991241 "Background: Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and progression of colorectal carcinoma (CRC) is unclear." 263 539 W2947789980.pdf 0 9 separator 0.8374652 ¶ 539 541 W2947789980.pdf 0 10 text 0.99536616 "Methods: We evaluated the effect of corticosterone (CORT) on azoxymethane and dextran sulfate sodium (AOM/ DSS)-induced carcinogenesis in the colorectum of C57BL/6 strain mice. Plasma level of CORT was detected by radioimmunoassay. The expression of proliferation markers (Ki-67 and PCNA), nuclear factor (NF)- κB p65 and phosphoto-p65 (P-p65), as well as cyclooxygenase (COX)-2 were determined by immunohistochemistry. Inflammation in colorectum was evaluated by histopathology." 541 1029 W2947789980.pdf 0 11 separator 0.6834433 ¶ 1029 1031 W2947789980.pdf 0 12 text 0.99442416 "Results: CORT feeding in drinking water of mice not only significantly elevated plasma CORT concentration, but also significantly increased the incidence and neoplasms burden (number and size of neoplasms) in colorectum. CORT also significant enhanced the expression of cell proliferation marker (Ki-67 and PCNA), NF- κB p65 and P-p65 as well as COX-2 in colorectal neoplasm of AOM/DSS-treated mice." 1031 1437 W2947789980.pdf 0 13 separator 0.8173479 ¶ 1437 1439 W2947789980.pdf 0 14 text 0.9990605 "Conclusion: In this study, we have found for the first time that CORT at stress level potentially promotes the growth and development of AOM/DSS-induced colorectal adenoma and carcinoma in mice. Up-regulation of NF- κB and COX-2 may be involved in the promoting effect of CORT." 1439 1721 W2947789980.pdf 0 15 separator 0.99391896 ¶ 1721 1723 W2947789980.pdf 0 16 text 0.37521157 Keywords 1723 1732 W2947789980.pdf 0 17 title 0.2750464 : 1732 1733 W2947789980.pdf 0 18 text 0.29130337 Corti 1733 1739 W2947789980.pdf 0 19 title 0.36055902 costerone 1739 1748 W2947789980.pdf 0 20 text 0.3037603 , Az 1748 1752 W2947789980.pdf 0 21 title 0.28540456 oxymethane 1752 1762 W2947789980.pdf 0 22 table 0.25662863 / 1762 1763 W2947789980.pdf 0 23 text 0.3059611 dextran 1763 1771 W2947789980.pdf 0 24 table 0.31595755 sodium 1771 1777 W2947789980.pdf 0 25 text 0.36577845 1777 1778 W2947789980.pdf 0 26 table 0.31543395 sulfate, 1778 1786 W2947789980.pdf 0 27 text 0.29989287 Color 1786 1792 W2947789980.pdf 0 28 table 0.27587342 ectal 1792 1797 W2947789980.pdf 0 29 text 0.2693817 c 1797 1799 W2947789980.pdf 0 30 table 0.3063327 arcinoma, 1799 1808 W2947789980.pdf 0 31 text 0.29232115 Tumor development, 1808 1827 W2947789980.pdf 0 32 paratext 0.22446167 1827 1828 W2947789980.pdf 0 33 text 0.2818149 ¶ Nuclear factor 1828 1844 W2947789980.pdf 0 34 paratext 0.31519744 - κB 1844 1848 W2947789980.pdf 0 35 separator 0.99606645 ¶ 1848 1850 W2947789980.pdf 0 36 title 0.91691345 Background 1850 1861 W2947789980.pdf 0 37 separator 0.99150074 ¶ 1861 1863 W2947789980.pdf 0 38 text 0.9994575 "Clinical studies have linked the experience of stressful events, such as pressure, cancer-related concerns and de- pression, to poor survival of cancer patients [ 1,2]. Preclin- ical studies also support that chronic stress has an impact on cancer progression and survival [ 3–5]. Glucocorticoids (GCs) are main stress hormones which are secreted dramatically in a state of stress, and play a critical role in the process of immunosuppression, anti-inflammationand homeostasis sustaining [ 6]. Synthetic GCs, such as dexamethasone, have been widely used as drugs to treat immune and inflammatory disorders. Moreover, GCs are clinically important as adjuvants in non-hematologic can- cer therapy to reduce acute toxicity and alleviate side effects induced by chemotherapy or radiotherapy [ 7]. GCs exert their biological effects by regulating the expression of genes and cross-talking with multiple trans-membrane signalling pathways [ 8]. The effects of GCs are mediated by glucocorticoid receptor (GR), which is ubiquitously expressed in all cells. Since the activation of GR by GCs control a variety of physiological and cellular processes, such as immune response, metabolism, cell proliferation, apoptosis and survival [ 9], the relationship between GCs*" 1863 3162 W2947789980.pdf 0 39 contact 0.9875174 Correspondence: lujian326@163.com 3162 3196 W2947789980.pdf 0 40 separator 0.8853684 ¶ 3196 3198 W2947789980.pdf 0 41 contact 0.8489009 †Bo Li and Yan Wang contributed equally to this work. 3198 3252 W2947789980.pdf 0 42 separator 0.8639681 ¶ 3252 3254 W2947789980.pdf 0 43 contact 0.98039186 "1Department of pathophysiology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People ’s Republic of China" 3254 3388 W2947789980.pdf 0 44 separator 0.8380873 ¶ 3388 3390 W2947789980.pdf 0 45 paratext 0.9429221 "Full list of author information is available at the end of the article © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.Liet al. BMC Cancer (2019) 19:94" 3390 4125 W2947789980.pdf 0 46 separator 0.50219697 4126 4127 W2947789980.pdf 0 47 paratext 0.9544031 ¶ https://doi.org/10.1186/s12885-019-5299-8 4127 4170 W2947789980.pdf 0 0 paratext 0.9887052 Sensors 2023 ,23, 1965 49 of 55 0 31 W4319924621.pdf 48 1 separator 0.7958194 ¶ 31 33 W4319924621.pdf 48 2 paratext 0.9839228 Sensors 2023 , 23, x FOR PEER REVIEW 51 of 57 33 80 W4319924621.pdf 48 3 separator 0.71774626 "¶ ¶" 81 92 W4319924621.pdf 48 4 caption 0.9311315 "Figure 91. Comparison of ML Classifiers with MSMO Accuracy by Class of Primary Dataset Related to DV Results ." 92 206 W4319924621.pdf 48 5 separator 0.9588149 ¶ ¶ 207 213 W4319924621.pdf 48 6 caption 0.9320968 Figure 92. Comparison of ML Classifiers with MSMO Fault Prediction by Class of Primary Dataset 213 308 W4319924621.pdf 48 7 separator 0.7179979 ¶ 309 311 W4319924621.pdf 48 8 caption 0.4527955 Related to D V 311 326 W4319924621.pdf 48 9 title 0.36742672 Results 326 334 W4319924621.pdf 48 10 caption 0.42688867 . 334 336 W4319924621.pdf 48 11 separator 0.9489113 ¶ 337 339 W4319924621.pdf 48 12 text 0.99574095 "The confusion matrix is used to calculate accuracy, precision, recall, and F -measure. It is used as an efficient technique for the classification of attributes based on qualitative response categories. Figure 93 shows the confusion matrix relate d to accuracy and fault prediction achieved through MSMO. The following confusion matrix indicates that the MSMO classification model gave the highest percentage of accuracy and less fault predic- tion error for the primary dataset against NB, LibSVM, MLR, SMO, KNN, and RF." 339 875 W4319924621.pdf 48 13 separator 0.99457353 ¶ 877 879 W4319924621.pdf 48 14 table 0.99379534 "NB LibSVM MLR SMO MSMO KNN RF Training 60% 64.04% 100.00% 96.30% 95.83% 96.54% 100.00% 100.00% Testing 20% 65.35% 44.28% 95.00% 94.64% 96.42% 92.14% 93.21% Validation 20% 59.28% 48.92% 95.00% 95.35% 96.07% 95.71% 96.42%0%20%40%60%80%100%MSMO Primary Dataset Results 0%10%20%30%40%50%60%70%80%90%100% NB LibSVM MLR SMO MSMO KNN RFMSMO Primary Dataset Fault Predict Training 60% Fault Predict Testing 20% Fault Predict Validation 20%" 880 1326 W4319924621.pdf 48 15 separator 0.9859732 ¶ 1326 1328 W4319924621.pdf 48 16 caption 0.8584087 "Figure 91. Comparison of ML Classifiers with MSMO Accuracy by Class of Primary Dataset Related to DV Results." 1328 1439 W4319924621.pdf 48 17 separator 0.9895739 ¶ 1439 1441 W4319924621.pdf 48 18 paratext 0.98158264 Sensors 2023 , 23, x FOR PEER REVIEW 51 of 57 1441 1488 W4319924621.pdf 48 19 separator 0.8589918 "¶ ¶" 1489 1500 W4319924621.pdf 48 20 caption 0.9396447 "Figure 91. Comparison of ML Classifiers with MSMO Accuracy by Class of Primary Dataset Related to DV Results ." 1500 1614 W4319924621.pdf 48 21 separator 0.96378714 ¶ ¶ 1615 1621 W4319924621.pdf 48 22 caption 0.9481189 Figure 92. Comparison of ML Classifiers with MSMO Fault Prediction by Class of Primary Dataset 1621 1716 W4319924621.pdf 48 23 separator 0.6574334 ¶ 1717 1719 W4319924621.pdf 48 24 caption 0.66942316 Related to D V Results . 1719 1744 W4319924621.pdf 48 25 separator 0.96356916 ¶ 1745 1747 W4319924621.pdf 48 26 text 0.99509275 "The confusion matrix is used to calculate accuracy, precision, recall, and F -measure. It is used as an efficient technique for the classification of attributes based on qualitative response categories. Figure 93 shows the confusion matrix relate d to accuracy and fault prediction achieved through MSMO. The following confusion matrix indicates that the MSMO classification model gave the highest percentage of accuracy and less fault predic- tion error for the primary dataset against NB, LibSVM, MLR, SMO, KNN, and RF." 1747 2283 W4319924621.pdf 48 27 separator 0.99419975 ¶ 2285 2287 W4319924621.pdf 48 28 table 0.99471396 "NB LibSVM MLR SMO MSMO KNN RF Training 60% 64.04% 100.00% 96.30% 95.83% 96.54% 100.00% 100.00% Testing 20% 65.35% 44.28% 95.00% 94.64% 96.42% 92.14% 93.21% Validation 20% 59.28% 48.92% 95.00% 95.35% 96.07% 95.71% 96.42%0%20%40%60%80%100%MSMO Primary Dataset Results 0%10%20%30%40%50%60%70%80%90%100% NB LibSVM MLR SMO MSMO KNN RFMSMO Primary Dataset Fault Predict Training 60% Fault Predict Testing 20% Fault Predict Validation 20%" 2288 2734 W4319924621.pdf 48 29 separator 0.986122 ¶ 2734 2736 W4319924621.pdf 48 30 caption 0.9252851 Figure 92. Comparison of ML Classifiers with MSMO Fault Prediction by Class of Primary Dataset 2736 2830 W4319924621.pdf 48 31 separator 0.6476859 ¶ 2830 2832 W4319924621.pdf 48 32 caption 0.8133558 Related to DV Results. 2832 2855 W4319924621.pdf 48 33 separator 0.9725607 ¶ 2855 2857 W4319924621.pdf 48 34 text 0.9699966 "Figures 89–92 show the result comparison of NB, LibSVM, MLR, SMO, MSMO, KNN, and RF in primary-dataset-related detailed accuracy by class (repair/failure) and prediction on further test-split data validation." 2857 3070 W4319924621.pdf 48 35 separator 0.7493739 ¶ 3070 3072 W4319924621.pdf 48 36 text 0.99064 "The confusion matrix is used to calculate accuracy, precision, recall, and F-measure. It is used as an efficient technique for the classification of attributes based on qualitative response categories. Figure 93 shows the confusion matrix related to accuracy and fault prediction achieved through MSMO. The following confusion matrix indicates that the MSMO classification model gave the highest percentage of accuracy and less fault prediction error for the primary dataset against NB, LibSVM, MLR, SMO, KNN, and RF." 3072 3597 W4319924621.pdf 48 37 separator 0.9717675 ¶ 3597 3599 W4319924621.pdf 48 38 text 0.95871234 "Figure 94 represents the error of the classifier that shows the values corresponding to true-positive, true-negative, false-positive, and false-negative values. In the Figure 94, the square box represents the errors in the actual class versus the predicted class." 3599 3866 W4319924621.pdf 48 0 paratext 0.9794705 "12 Vol:.(1234567890) Scientific Reports | (2020) 10:17270 | https://doi.org/10.1038/s41598-020-74286-4 www.nature.com/scientificreports/" 0 149 W3093222346.pdf 11 1 bibliography 0.9975356 "48. Thommes, M. et al. Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report). Pure Appl. 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RSC Adv. 9(18), 9878–9886. https ://doi.org/10.1039/C9RA0 1090D (2019)." 3076 3300 W3093222346.pdf 11 26 separator 0.99231327 ¶ 3300 3302 W3093222346.pdf 11 27 title 0.9808216 Acknowledgements 3302 3319 W3093222346.pdf 11 28 separator 0.9936323 ¶ 3319 3321 W3093222346.pdf 11 29 text 0.998624 "The described article was carried out as part of EFOP-3.6.1-16-2016-00011 “Y ounger and Renewing University- Innovative Knowledge City-institutional development of the University of Miskolc aiming at intelligent speciali - sation” project implemented in the framework of the Szechenyi 2020 program. The realization of this project is supported by the European Union, co-financed by the European Social Fund. The authors are thankful to Gabor Karacs for TEM investigation, to Dr. Jaroslav Sychev for the consultation on evaluation of the electrochemical results, Dheeraj Varanasi and Jamal Eldin F.M. Ibrahim for their contribution in structuring of the paper." 3321 3988 W3093222346.pdf 11 30 separator 0.9968511 ¶ 3988 3990 W3093222346.pdf 11 31 title 0.98756903 Author contributions 3990 4011 W3093222346.pdf 11 32 separator 0.99587727 ¶ 4011 4013 W3093222346.pdf 11 33 text 0.9994284 "K.N., A.S. and P .B. planned and designed the experiments, wrote the main text of the manuscript and made final evaluations of the results. W .W . and V .S. did the electrochemical tests and evaluation of the results. D.K.-H. analysed the samples in the SEM investigations. T.F. did the BET tests. F.K. carried out the XRD measurements and evaluations. All authors reviewed the manuscript." 4013 4406 W3093222346.pdf 11 34 separator 0.99665654 ¶ 4406 4408 W3093222346.pdf 11 35 title 0.9725649 Competing interests 4408 4428 W3093222346.pdf 11 36 separator 0.9915285 ¶ 4430 4432 W3093222346.pdf 11 37 text 0.7624977 The authors declare no competing interests. 4432 4476 W3093222346.pdf 11 38 separator 0.99173486 ¶ 4476 4478 W3093222346.pdf 11 39 title 0.8712279 Additional information 4478 4501 W3093222346.pdf 11 40 separator 0.9817505 ¶ 4501 4503 W3093222346.pdf 11 41 contact 0.5964928 Correspondence and requests for materials should be addressed to K.N. or P .B. 4503 4582 W3093222346.pdf 11 42 separator 0.44995248 ¶ 4582 4584 W3093222346.pdf 11 43 contact 0.47169867 Reprints and permissions information is available at www. 4584 4642 W3093222346.pdf 11 44 text 0.4779715 nature 4642 4648 W3093222346.pdf 11 45 contact 0.49266773 . 4648 4649 W3093222346.pdf 11 46 text 0.42483056 com 4649 4652 W3093222346.pdf 11 47 contact 0.52946633 / 4652 4653 W3093222346.pdf 11 48 text 0.45155564 reprints. 4653 4662 W3093222346.pdf 11 49 separator 0.99118173 ¶ 4662 4664 W3093222346.pdf 11 50 title 0.7548454 Publisher’s note 4664 4681 W3093222346.pdf 11 51 text 0.541146 "Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations." 4681 4803 W3093222346.pdf 11 52 separator 0.98336935 ¶ 4803 4805 W3093222346.pdf 11 53 paratext 0.9463509 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. 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To view a copy of this licence, visit http://creat iveco mmons .org/licen ses/by/4.0/." 4805 5673 W3093222346.pdf 11 54 separator 0.75242543 ¶ 5673 5675 W3093222346.pdf 11 55 paratext 0.9812668 © The Author(s) 2020 5675 5696 W3093222346.pdf 11 0 math 0.4458872 Ozonic1 der E’laiil 0 19 W2016963447.pdf 3 1 title 0.31860164 insu 19 23 W2016963447.pdf 3 2 math 0.73855394 "ure!, CH,(CHI),CH-CH.(CH~),CO&. \/’ 0," 23 67 W2016963447.pdf 3 3 separator 0.983111 ¶ 68 70 W2016963447.pdf 3 4 text 0.99889296 "Deshalb wird besser die freie Saure (5 g) in Chloroform (100 ccm) aufgenommen und vier bis funf Stunden in Kalte- niischung ozonisirt. ‘Nach dem Abdampfen hinterbleibt das Ozonid als fa,rblose, gelatinose Masse. Die Ausbeute ist (luau- titativ. Dasselbe verbrenut auf dem Platinblech langsam ohne zu verpuffen. Die mit Wasser erliitzte Substanz ergab die charakteristischen Reactionen : 1) Wasserstoffsuperoxydprobe, 2) Reduction von E’ehling’scher Losung (schwach), 3) Oxy- dation von Jodkalium, 4) Entfarbung von Indigo und Kalium- permanganatlosung." 70 650 W2016963447.pdf 3 5 separator 0.9793446 ¶ 651 653 W2016963447.pdf 3 6 text 0.9992458 "Zur Elementaranalyse wurde das Ozonid in menig Essig- ester aufgenommen und mit Petrolather gefallt, danach bis zur Gewiclitsconstanz im Vacuumexsiccator getrocknet." 653 825 W2016963447.pdf 3 7 separator 0.51608086 ¶ 826 828 W2016963447.pdf 3 8 text 0.9903826 0,2119 g gaben 0,4786 CO, und 0,1801 H,O. 828 870 W2016963447.pdf 3 9 separator 0.88427866 ¶ 871 873 W2016963447.pdf 3 10 table 0.9918424 "Berechilet fiir Gefiiiideii C,,H3,0s Anlagerung roil 40 c 62,42 61,46 €I 933 9,51" 873 967 W2016963447.pdf 3 11 separator 0.9866758 ¶ 968 970 W2016963447.pdf 3 12 text 0.99673927 "Das Ozonid der Oelsilure, ebenso bereitet , unterscheidet sich in keiner Weise von dem eben beschriebenen, indessen erhalt man die Wasserstoffsuperoxydprobe hier nur sehr schrver." 970 1156 W2016963447.pdf 3 13 separator 0.9866164 ¶ 1157 1159 W2016963447.pdf 3 14 text 0.99497586 "Die Spaltung der Ozonide geschieht am besten wie folgt: Man erhitzt sie mit Wasser am Ruckflusskhhler ein bis zwei Stunden, dann wird das im Wasser schwimmende Oel mit Sether aufgenommen, getrcnnt und die atherische Losung mit Natrium- bicarbonat und Wasser geschiittelt. IIierdurch wird der Halb- aldehyd der Azelainsaure und diese SBurc selbst dem Aether entzogen, dieselben gehen als Natriumsalze in das Wasser I, wabrcnd Nonylaldehyd und dic schwach saure Pelargonsaure im Aether I1 verbleiben." 1159 1682 W2016963447.pdf 3 15 separator 0.99607766 ¶ 1683 1685 W2016963447.pdf 3 16 paratext 0.93406105 Annalen der Chernie 343. Ed. 24 1685 1717 W2016963447.pdf 3 0 title 0.88369364 Miller et al. Novel Plasma Proteins Diagnose Concussion 0 55 W4200235010.pdf 6 1 separator 0.99479115 ¶ 55 57 W4200235010.pdf 6 2 text 0.99901646 "Wedemonstratedchangesinplasmaproteinsafterconcussion that may be useful for injury diagnosis in adolescent athlet es, but other plasma biomarkers have been proposed ( 13). For example, several protein biomarkers are released after injury and are relatively specific to a wide variety of brain cells, including neurons (UCH-L1, NF-L, Tau, NSE, SNTF), astrocytes (GFAP, S100 β) and oligodendrocytes (MBP). To date, only a handful of brain injury protein biomarkers have shown some degree of diagnostic accuracy, such as a combination of GFAP and UCH-L1 ( 41). These latter two biomarkers are FDA approved to identify concussed adults in need of computerized tomography scanning, but their usefulness to diagnose concussion in adolescents is unclea r (42,43). With the exception of neurofilament light chain (NEFL,SupplementaryTables1,2 ),thebraininjurybiomarkers listed above were not part of our targeted panels, and therefore not measured in this study. Nonetheless, we did measure plasma GFAP levels for a comparison. Plasma GFAP was elevated after concussion, but fell short of significance, pe rhaps due to the post-injury blood sampling time frame ( 42,43) and/or insufficient ELISA kit sensitivities. An alternative to protein measurements is mass spectrometry measurements of plasma glycerophospholipids, yielding AUCs for adolescent concussion diagnosis equal or greater to the classical prote in biomarkers( 12,15)." 57 1524 W4200235010.pdf 6 3 separator 0.9457503 ¶ 1524 1526 W4200235010.pdf 6 4 text 0.99757826 "The putative concussion biomarkers discovered here may serve well as a standalone point of care screening tool, or as part of a multimodal concussion diagnostic model. For the former, the identified proteins would be amenable to immunoassay technology, including lateral flow. For the latter, protein measurements may be combined with other approaches including electroencephalography, neurocognitiv e tests and standard concussion assessment tools ( 44), as well as multiparametricadvancedimaging( 19,45)." 1526 2047 W4200235010.pdf 6 5 separator 0.96616507 ¶ 2047 2049 W4200235010.pdf 6 6 text 0.9996899 "Our study has several limitations. First, our study evaluat ed a limited number of adolescent athletes. Despite this caveat , a strong predictive model was identified with high statistical significance illustrating the potential of these proteins for diagnostic utility. Second, we did not have baseline measurements from each athlete and, therefore, we compared concussed athletes to a control cohort who were age-, sex- and activity-matched. Third, our matched control group was uninjured; further studies should add an additional contro l group consisting of matched athletes with musculoskeletal injuries. Fourth, our study population was only male. Follow- up studies should investigate protein changes in both sexes." 2049 2792 W4200235010.pdf 6 7 separator 0.7600237 ¶ 2792 2794 W4200235010.pdf 6 8 text 0.99956137 "Finally, the temporal threshold for accurately measuring changes in the identified proteins is unclear at present, but certainly falls within our 72-h post-injury time period. Despi te these caveats listed above, we emphasize that these exact cohorts are extremely well-characterized having been stud ied with both multi-parametric MRI ( 19) and metabolomics (12,15)." 2794 3173 W4200235010.pdf 6 9 separator 0.94612706 ¶ 3173 3175 W4200235010.pdf 6 10 text 0.9991714 "In summary, we identify a number of plasma proteins that change after concussion in adolescent athletes." 3175 3282 W4200235010.pdf 6 11 separator 0.6146922 ¶ 3282 3284 W4200235010.pdf 6 12 text 0.99954534 "Importantly, a combination of up to three novel plasmaproteins (ATOX1, SPARC and NT5C3A), which are amenable to point of care immunoassay testing, have been identified as putative concussion biomarkers. Despite a paucity of studies on these three identified proteins, the available evidence points to their roles in modulating tissue inflammation and regulating integrity of the cerebra l microvasculature. Future studies should endeavor to have a larger cohort of athletes, comprised of both sexes, with measurements at baseline, post-injury and at multiple interval s duringrecovery." 3284 3885 W4200235010.pdf 6 13 separator 0.99676466 ¶ 3885 3887 W4200235010.pdf 6 14 title 0.9924255 DATA AVAILABILITY STATEMENT 3887 3915 W4200235010.pdf 6 15 separator 0.9916874 ¶ 3915 3917 W4200235010.pdf 6 16 text 0.997444 "The original contributions presented in the study are includ ed in the article/ SupplementaryMaterial further inquiries can be directedtothecorrespondingauthor." 3917 4082 W4200235010.pdf 6 17 separator 0.99636286 ¶ 4082 4084 W4200235010.pdf 6 18 title 0.9906393 ETHICS STATEMENT 4084 4101 W4200235010.pdf 6 19 separator 0.9925705 ¶ 4101 4103 W4200235010.pdf 6 20 text 0.9978769 "The studies involving human participants were reviewed and approved by Human Ethics Review Board, Western University. Written informed consent to participate in this study was provided by the participants’ legal guardian/next ofkin." 4103 4344 W4200235010.pdf 6 21 separator 0.9965439 ¶ 4344 4346 W4200235010.pdf 6 22 title 0.98924047 AUTHOR CONTRIBUTIONS 4346 4367 W4200235010.pdf 6 23 separator 0.99224263 ¶ 4367 4369 W4200235010.pdf 6 24 bibliography 0.54002196 "DF: concept, methods design, data collection, data analysis , data interpretation, manuscript writing, and" 4369 4478 W4200235010.pdf 6 25 text 0.46962085 4478 4479 W4200235010.pdf 6 26 bibliography 0.51008654 "submission. MM, MP, andMD:dataanalysisandmanuscriptwriting.MR,LF,AD,RB, GD,RM,JS,ED,andIP:datacollection,andcriticalreviewofth e manuscript." 4479 4625 W4200235010.pdf 6 27 text 0.55513203 "All authors contributed to the article and approve d thesubmittedversion." 4625 4701 W4200235010.pdf 6 28 separator 0.99485683 ¶ 4701 4703 W4200235010.pdf 6 29 title 0.98726547 FUNDING 4703 4711 W4200235010.pdf 6 30 separator 0.9914004 ¶ 4711 4713 W4200235010.pdf 6 31 text 0.99767745 "DF received funding for subject recruitment and sample procurement from the Children’s Health Foundation (London, Ontario, Canada; https://childhealth.ca/), and funding fo r targeted proteomics from Neurolytixs Inc. (Toronto, Ontari o, Canada; https://www.neurolytixs.com/). The Children’s He alth Foundation was not involved in the study design, collection , analysis, interpretation of data, the writing of this article or the decisiontosubmititforpublication." 4713 5190 W4200235010.pdf 6 32 separator 0.99642015 ¶ 5190 5192 W4200235010.pdf 6 33 title 0.98355997 ACKNOWLEDGMENTS 5192 5208 W4200235010.pdf 6 34 separator 0.9905705 ¶ 5208 5210 W4200235010.pdf 6 35 text 0.83782977 "The authors thank the staff of the Fowler Kennedy Sports MedicineCentreforaidwithsubjectrecruitmentandMs.Christy Barreirafortechnicalsupport." 5210 5355 W4200235010.pdf 6 36 separator 0.9943496 ¶ 5355 5357 W4200235010.pdf 6 37 title 0.98887396 SUPPLEMENTARY MATERIAL 5357 5380 W4200235010.pdf 6 38 separator 0.98289555 ¶ 5380 5382 W4200235010.pdf 6 39 text 0.925686 "The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.338 9/fneur. " 5382 5506 W4200235010.pdf 6 40 paratext 0.84039897 ¶ 2021.787480/full#supplementary-material 5506 5547 W4200235010.pdf 6 41 separator 0.87171316 ¶ 5547 5549 W4200235010.pdf 6 42 paratext 0.9817826 Frontiers in Neurology | www.frontiersin.org 7 December 2021 | Volume 12 | Article 787480 5549 5639 W4200235010.pdf 6 0 separator 0.99281913 ¶ 1 2 W4310792518.pdf 3 1 caption 0.977871 Figure 1. Illustration of input satellite-based images and target region context. The pink rectangle covers the input satellite radiances used to capture increasing amounts of context around the target patch (blue 6 220 W4310792518.pdf 3 2 text 0.7866497 220 221 W4310792518.pdf 3 3 caption 0.8920878 rectangle 221 230 W4310792518.pdf 3 4 text 0.99909925 ). For Stage 1, only rain/no rain needs to be predicted for each pixel using satellite-based images and rainfall rate products from one year only, covering Feb. to Dec. 2019, on three European regions (boxi_0015, boxi_0034, boxi_0076). For the Stage 2 Core challenge, forecasting rain events of rain rate threshold 0.2 mm uses much more data, including all the data from Stage 1, and extending it to cover 7 regions (boxi_0015, boxi_0034, boxi_0076, roxi_0004, roxi_0005, roxi_0006, roxi_0007) with training data from 2 years (2019 and 2020). A total number of 228928 samples in training dataset and 840 samples in validation dataset were generated using a sliding window method. In the Stage 2 Transfer Learning challenge, test data of 3 additional regions (e.g., roxi_0008, roxi_0009, roxi_0010) in 3 years (2019-2021), and existing 7 regions in the third year (2021) were used to assess the temporal and/or spatial transfer learning. In addition, static data with the elevation of the terrain, longitude and latitude are available for each region. 230 1281 W4310792518.pdf 3 5 title 0.9775855 2.2 Description of models and training strategy 2.2.1 Model architectures 1282 1356 W4310792518.pdf 3 6 text 0.99978584 During Stage 1, we tested a couple of neural network models that are used on spatial-temporal tasks, mainly three types: U-Nets (U-Net [14], 3D U-Net, and U2Net [15]); RNNs (ConvLSTM [7] and trajGRU [1]); and Transformers (Swin Transformer [16], EarthFormer). Based on the experiment results of Stage 1 (described in Results section), 3D U-Net and EarthFormer were used on Stage 2. As shown in Figure 2, the 3D U-Net model consists of five encoder blocks, four decoder blocks and one output block. The encoder block performs a 2x downsampling, including 3d convolutional layers, max-pooling layers, BatchNorm, ReLU activation function, and Dropout3d layer. The decoder block consists of 3d convolutional layers, upsampling layers via transposed convolution, BatchNorm and ReLU activation function. The convolutional layers at different depths can extract spatial features at different resolutions, which is crucial for precipitation prediction, due to the multiscale nature of weather phenomena [17]. Each pooling layer downsample the feature maps detected by convolutional layer to a lower spatial resolution. The Dropout layer helps prevent overfitting by randomly setting input units to 0 with a probability of 0.4 at each step during training time. The BatchNorm layer is a method used to make training of deep neural networks faster and stable by standardizing the inputs to a layer for each mini-batch [18]. 1356 2771 W4310792518.pdf 3 0 paratext 0.98807335 Page 2/23 0 9 W4226316754.pdf 1 1 title 0.51633644 Abstract 9 17 W4226316754.pdf 1 2 separator 0.9955757 ¶ 17 19 W4226316754.pdf 1 3 text 0.9944379 "Management of light is a crucial task in solar cell design and structure because it increases the path length of the light inside, which in turn increases the probability of electron-hole pair generation. This study addresses the impact of a pyramidal textured structure on spectral transmission in the morphology of silicon. The morphology of silicon wafers was investigated using PC3S spectral transmission software to study the spectral transmission, re" 19 484 W4226316754.pdf 1 0 paratext 0.82301843 "| 6343 ROMERO- MUJALLI Et AL." 4 37 W3125883860.pdf 4 1 separator 0.9901588 ¶ 37 39 W3125883860.pdf 4 2 text 0.9995943 "change and the phenotypic response (DeWitt et al., 1998), or due to physiological limits or other constraints of the plasticity mechanism (e.g., of the underlying gene regulatory network). Furthermore, plas - ticity can result— at least for quantitative traits— from a complex rela - tionship between genotype and phenotype, with the developmental system responding flexibly to internal (genotype) and external in - puts (environment) (Laland et al., 2015). To this end, we compare linear reaction norms with alternative plasticity types, including a flexible developmental system. As a consequence, multiple geno - types can have the same phenotype and are mutationally intercon - nected (many- to- one genotype– phenotype map, Aguilar- Rodríguez et al., 2018; Ahnert, 2017; Wagner, 2008). This assumption leads to new insights into the origin of cryptic genotypic variation, genetic accommodation, and the maintenance of genetic variation in natural populations." 39 1034 W3125883860.pdf 4 3 separator 0.975675 ¶ 1034 1036 W3125883860.pdf 4 4 text 0.99972135 "From an ecological perspective, the evaluation of different forms of stochastic environmental conditions is important since the type (i.e., the color) of the environmental noise differently af - fects population extinction risk (Schwager et al., 2006; Mustin et al., 2013). Colored environmental noise arises when fluctuations of climatic variables such as temperature differ with regard to their serial autocorrelation between consecutive time units (typically years; Björklund et al.,, 2009; Laakso et al., 2001, 2004; Schwager et al., 2006). For instance, Mustin et al., (2013) found that extinction risk is expected to be high for populations experiencing directional climate change and inhabiting climates with reddish (i.e., positively autocorrelated) stochasticity. However, they did not consider sce - narios of negatively autocorrelated stochasticity (blue noise), nor the effect of plasticity on population persistence. How such environ - mental stochasticity may promote the degree and mode of plastic responses has received less attention." 1036 2109 W3125883860.pdf 4 5 separator 0.9966211 ¶ 2109 2111 W3125883860.pdf 4 6 title 0.9895403 2 | METHODS 2111 2124 W3125883860.pdf 4 7 separator 0.9965731 ¶ 2124 2126 W3125883860.pdf 4 8 text 0.99973464 "To study the effect of adaptive and nonadaptive phenotypic plas - ticity on population persistence under scenarios of environmental change, we developed an eco- evolutionary individual- based model (IBM) of a geographically isolated panmictic population of a sexual species with nonoverlapping generations experiencing stochastic di - rectional climate change. The focus was on studying the ability of a population to adapt to its local environment (no migration was possi - ble). This modeling setup could resemble a fish population inhabiting a lake, or a plant or animal population inhabiting a highly fragmented environment where movement opportunities are constrained. Populations could differ in fecundity and intrinsic population dy - namics (different life history strategies). The model also allows for different forms of environmental stochasticity or noise color: uncor - related white noise typical for terrestrial locations; positively auto - correlated red noise, which had been found in coastal and marine habitats, Vasseur & Yodzis, 2004; and negatively autocorrelated blue noise. Blue noise is less common, but recent evaluations of climate spectral exponents suggest that temperature has turned bluer (i.e., tends toward more negatively autocorrelated stochasticity) in most continents in the last century (García- Carreras & Reuman, 2011)." 2126 3509 W3125883860.pdf 4 9 separator 0.9486495 ¶ 3509 3511 W3125883860.pdf 4 10 text 0.9981066 "The model was created using the freely available software plat - form NetLogo 6.0.2 (Wilensky, 1999) and is available for download from https://github.com/danie lrm84/ PanMo del33. A full descrip - tion of the model that follows the ODD (Overview, Design, con - cepts, and Details) protocol (Grimm et al., 2006, 2010) can be found in Appendix A. Below, only model features that were used in this study are explained. The sequence of model operations was as fol - lows: set initial environment and population (assumed to be locally adapted), update phenotypic response, check for degree of adap - tation (as fitness proxy), computation of fecundity, reproduction of adults, inheritance, die- off of adults, check for extinction, and up - date of the environmental state before repeating the loop (Figure 1)." 3511 4343 W3125883860.pdf 4 11 separator 0.9972869 ¶ 4343 4345 W3125883860.pdf 4 12 title 0.98720235 2.1 | Environment 4345 4364 W3125883860.pdf 4 13 separator 0.99659324 ¶ 4364 4366 W3125883860.pdf 4 14 text 0.99973947 "The environment imposed a phenotypic optimum θt (hereafter, en - vironmental optimum) which could change at constant speed every generation depending on the simulated scenario of environmental change. Thus, θ t = θ0 + η t determined the directional trend of the optimum θt in a deterministic environment (no stochasticity). The pa - rameter θ0 was the initial environmental optimum (when t = 0), and η was the rate of environmental change. By varying the parameter η, we simulated different scenarios of directional climate change (e.g., no change, slow, medium, rapid climate change). Stochastic colored noise around θ t was implemented to simulate different scenarios of environmental stochasticity (Figure 2). This method has been recom - mended for the simulation of directional climate change scenarios (Kopp & Matuszewski, 2014; Vincenzi, 2014)." 4366 5243 W3125883860.pdf 4 15 separator 0.95524323 ¶ 5243 5245 W3125883860.pdf 4 16 text 0.9992666 "Stochasticity according to colored noise was implemented such that the environmental optimum was determined by θ t = θ*t + φt, where θ*t gave the directional trend of the mean environmental optimum as specified above and φt = αφt−1 + βξt the environmental stochasticity. The parameter α governed the level of environmen - tal autocorrelation and therefore allowed for different forms of stochasticity or noise color as in Björklund et al. (2009): −1 < α < 0, blue noise; α = 0, white noise, and 0 < α < 1, red noise (Figure 2)." 5245 5792 W3125883860.pdf 4 17 separator 0.9615737 ¶ 5793 5795 W3125883860.pdf 4 18 text 0.9987725 "Several scenarios of noise color (values of α) were explored, rang - ing from negatively autocorrelated environmental conditions or blue noise over uncorrelated (white noise) to positively autocorrelated environmental conditions or red noise (see Table 1). The parameter β = σ √ 1−/u1D6FC2 was the adjusted environmental variance for all de - grees of autocorrelation, as in (Schwager et al., 2006), and σ2 = 1 was the environmental variance. The parameter ξt was a random value, normally distributed with zero mean and unity as variance." 5795 6351 W3125883860.pdf 4 19 separator 0.9970025 ¶ 6351 6353 W3125883860.pdf 4 20 title 0.98897195 2.2 | The population 6353 6374 W3125883860.pdf 4 21 separator 0.99653447 ¶ 6374 6376 W3125883860.pdf 4 22 text 0.9996793 Individuals in the population were characterized by sex, stage (whether adult or juvenile), degree of adaptation (fitness proxy, 6376 6505 W3125883860.pdf 4 0 paratext 0.98531216 Materials 2019 ,12, 615 9 of 10 0 31 W2913480537.pdf 8 1 separator 0.9900205 ¶ 31 33 W2913480537.pdf 8 2 bibliography 0.99764884 "12. Zschieschang, U.; Hofmockel, R.; Rödel, R.; Kraft, U.; Kang, M.J.; Takimiya, K.; Zaki, T.; Letzkus, F.; Butschke, J.; Richter, H.; et al. Megahertz operation of flexible low-voltage organic thin-film transistors. Org. Electron. 2013 ,14, 1516–1520. [CrossRef]" 33 299 W2913480537.pdf 8 3 separator 0.90011495 ¶ 299 301 W2913480537.pdf 8 4 bibliography 0.9979966 "13. 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[CrossRef]" 4012 4287 W2913480537.pdf 8 39 separator 0.94707024 ¶ 4287 4289 W2913480537.pdf 8 40 bibliography 0.99748665 "31. Milvich, J.; Zaki, T.; Aghamohammadi, M.; Rödel, R.; Kraft, U.; Klauk, H.; Burghartz, J.N. Flexible low-voltage organic phototransistors based on air-stable dinaphtho[2,3-b:2’,3’-f]thieno[3,2-b]thiophene (DNTT). Org. Electron. 2015 ,20, 63–68. [CrossRef]" 4289 4552 W2913480537.pdf 8 41 separator 0.9362658 ¶ 4552 4554 W2913480537.pdf 8 42 bibliography 0.99804175 32. Becke, A.D. Density-functional thermochemistry . III. The role of exact exchange. J. Chem. Phys. 1993 ,98, 5648–5652. 4554 4676 W2913480537.pdf 8 43 separator 0.9284353 ¶ 4676 4678 W2913480537.pdf 8 44 bibliography 0.994576 [CrossRef] 4678 4689 W2913480537.pdf 8 0 paratext 0.9857489 fnagi-14-811059 February 23, 2022 Time: 15:45 # 6 0 49 W4214582344.pdf 5 1 separator 0.8867697 ¶ 49 51 W4214582344.pdf 5 2 title 0.98051304 Zhao et al. Circulating Cytokines and PD Risk 51 97 W4214582344.pdf 5 3 separator 0.9941778 ¶ 97 99 W4214582344.pdf 5 4 caption 0.9966502 "FIGURE 2 | Scatterplot of genetic association with circulating levels of MIP1b against the genetic association with PD risk. Each black dot indicates an SNP , plotted by the estimate of SNP on the MIP1b levels and the estimate of SNP on PD risk with standard error bars. The slope of the line represents the causal relationship, and each method has a different line. PD, Parkinson’s disease; SNP , single-nucleotide polymorphism." 99 533 W4214582344.pdf 5 5 separator 0.9289427 ¶ 533 535 W4214582344.pdf 5 6 caption 0.72276086 the 535 539 W4214582344.pdf 5 7 text 0.96437234 "MR-PRESSO test showed that no outlier was found for all cytokines, except for TRAIL ( P= 0.016)." 539 638 W4214582344.pdf 5 8 separator 0.9964309 ¶ 638 640 W4214582344.pdf 5 9 title 0.9850203 "Circulating Inflammatory Cytokines and Age at the Onset of Parkinson’s Disease" 640 720 W4214582344.pdf 5 10 separator 0.99082494 ¶ 720 722 W4214582344.pdf 5 11 text 0.9995732 "Except for identifying the correlation between inflammatory cytokines and PD risk mentioned earlier, we also detected the causal relationships between the circulating levels of these cytokines and the age of PD onset. Unfortunately, there was no evidence to support the causal relationships between these 19 cytokines and age at the onset of PD ( Table 2 ). Moreover, no statistical evidence of instrument heterogeneity was detected using Cochran’s Q-test except for IP10 ( I2= 79.1%, P= 0.029)." 722 1231 W4214582344.pdf 5 12 separator 0.65738755 ¶ 1231 1233 W4214582344.pdf 5 13 text 0.9995877 "When applying MR Egger regression, evidence of potential pleiotropy was only observed in GROa ( P= 0.029), while other inflammatory cytokines did not show any pleiotropy. Besides,no SNP was detected as an outlier through the MR-PRESSO test ( Table 2 )." 1233 1491 W4214582344.pdf 5 14 separator 0.9968196 ¶ 1491 1493 W4214582344.pdf 5 15 title 0.991744 DISCUSSION 1493 1504 W4214582344.pdf 5 16 separator 0.9954707 ¶ 1504 1506 W4214582344.pdf 5 17 text 0.9991122 "Parkinson’s disease is a progressive and disabling neurodegenerative disease that mainly affects individuals in their later years of life and its course may vary from 6.9 to 14.3 years (Macleod et al., 2014; Marras et al., 2018). It has been reported that in 2016 alone, PD caused 211,296 deaths and 3.2 million disability-adjusted life-years globally (GBD 2016 Parkinson’s Disease Collaborators, 2018). Despite the long course of the disease and its huge impact on life expectance for elders, the intervention for PD prevention and therapy is still deficient, and the biological mechanism underlying PD etiology is not yet well understood. Thus, we took advantage of a two-sample MR ¶" 1506 2210 W4214582344.pdf 5 18 paratext 0.9667601 Frontiers in Aging Neuroscience | www.frontiersin.org 6 March 2022 | Volume 14 | Article 811059 2210 2306 W4214582344.pdf 5 0 title 0.8644553 "An automatic pipeline for PET/MRI attenuation correction validation in the brain" 0 83 W4388657605.pdf 0 1 separator 0.8984069 ¶ 83 85 W4388657605.pdf 0 2 paratext 0.6882251 Mah 85 89 W4388657605.pdf 0 3 contact 0.4087367 d 89 90 W4388657605.pdf 0 4 paratext 0.49919453 joub Ham 90 98 W4388657605.pdf 0 5 contact 0.46223626 di 98 100 W4388657605.pdf 0 6 paratext 0.61699414 1* , 100 105 W4388657605.pdf 0 7 contact 0.48389575 Chunwei Ying 105 118 W4388657605.pdf 0 8 paratext 0.55800325 1, 118 120 W4388657605.pdf 0 9 contact 0.5258405 Hongyu 120 127 W4388657605.pdf 0 10 paratext 0.5317533 An1,2,3,4 and Richard La 127 152 W4388657605.pdf 0 11 contact 0.49001208 forest 152 158 W4388657605.pdf 0 12 paratext 0.7022521 1 158 159 W4388657605.pdf 0 13 separator 0.9921857 ¶ 160 162 W4388657605.pdf 0 14 title 0.86027664 Introduction 162 175 W4388657605.pdf 0 15 separator 0.9914509 ¶ 175 177 W4388657605.pdf 0 16 text 0.99591315 "Positron emission tomography (PET) attenuation correction (AC) is crucial for accu - rate PET tracer’s quantification [1 ]. Hybrid PET Magnetic Resonance Imaging (PET/ MRI) gained interest due to its high soft-tissue contrast resolution, especially for neurological [2 ] oncology applications [3 ] and its low exposure to ionizing radiation compared to hybrid PET Computed Tomography (PET/CT), especially for pediatric Abstract" 177 616 W4388657605.pdf 0 17 separator 0.9897407 ¶ 617 619 W4388657605.pdf 0 18 text 0.9981662 "Purpose: Challenges in PET/MRI quantitative accuracy for neurological uses arise from PET attenuation correction accuracy. We proposed and evaluated an automatic pipeline to assess the quantitative accuracy of four MRI-derived PET AC methods using analytically simulated PET brain lesions and ROIs as ground truth for PET activity." 619 960 W4388657605.pdf 0 19 separator 0.86297387 ¶ 960 962 W4388657605.pdf 0 20 text 0.99900025 "Methods: Our proposed pipeline, integrating a synthetic lesion insertion tool and the FreeSurfer neuroimaging framework, inserts simulated spherical and brain ROIs into PET projection space, reconstructing them via four PET MRAC techniques. Utilizing an 11-patient brain PET dataset, we compared the quantitative accuracy of four MRACs (DIXON, DIXONbone, UTE AC, and DL-DIXON) against the gold standard PET CTAC, eval- uating MRAC to CTAC activity bias in spherical lesions and brain ROIs with and without background activity against original (lesion free) PET reconstructed images." 962 1562 W4388657605.pdf 0 21 separator 0.9231133 ¶ 1562 1564 W4388657605.pdf 0 22 text 0.9991221 "Results: The proposed pipeline yielded accurate results for spherical lesions and brain ROIs, adhering to the MRAC to CTAC pattern of original brain PET images. Among the MRAC methods, DIXON AC exhibited the highest bias, followed by UTE, DIXON- Bone, and DL-DIXON showing the least. DIXON, DIXONbone, UTE, and DL-DIXON showed MRAC to CTAC biases of − 5.41%, − 1.85%, − 2.74%, and 0.08% respectively for ROIs inserted in background activity; − 7.02%, − 2.46%, − 3.56%, and − 0.05% for lesion ROIs without background; and − 6.82%, − 2.08%, − 2.29%, and 0.22% for the original brain PET images’ 16 FreeSurfer brain ROIs." 1564 2203 W4388657605.pdf 0 23 separator 0.8851087 ¶ 2203 2205 W4388657605.pdf 0 24 text 0.9994564 "Conclusion: The proposed pipeline delivers accurate results for synthetic spherical lesions and brain ROIs, with and without background activity consideration, enabling the evaluation of new attenuation correction approaches without utilizing measured PET emission data. Additionally, it offers a consistent method to generate realistic lesion ROIs, potentially applicable in assessing further PET correction techniques." 2205 2638 W4388657605.pdf 0 25 separator 0.99285704 ¶ 2638 2640 W4388657605.pdf 0 26 paratext 0.90701365 "Keywords: Quantitative brain PET, PET attenuation correction, PET/MRI, PET/CT, FreeSurfer brain atlas, Virtual synthetic PET imagingOpen Access © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the mate - rial. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by/4.0/.ORIGINAL RESEARCHHamdi et al. EJNMMI Physics (2023) 10:71 https://doi.org/10.1186/s40658-023-00590-3EJNMMI Physics" 2640 3811 W4388657605.pdf 0 27 separator 0.9103465 ¶ 3811 3813 W4388657605.pdf 0 28 contact 0.99530256 "*Correspondence: hamdi.m@wustl.edu" 3813 3853 W4388657605.pdf 0 29 separator 0.8911168 ¶ 3853 3855 W4388657605.pdf 0 30 contact 0.98463285 "1 Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis, MO, USA 2 Neurology, Washington University in St. Louis, St. Louis, MO, USA 3 Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA 4 Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA" 3855 4227 W4388657605.pdf 0 0 paratext 0.915383 Vidović K, Šoštarić M, Budimir D. 0 33 W2989923758.pdf 5 1 title 0.85928714 An Overview of Indicators and Indices Used for Urban Mobility Assessment 33 106 W2989923758.pdf 5 2 separator 0.96643925 ¶ 106 108 W2989923758.pdf 5 3 paratext 0.93786573 708 Promet – Traffic & Transportation, Vol. 31, 2019, No. 6, 703-714intended 108 185 W2989923758.pdf 5 4 title 0.72810656 "for the traffic management and the Intelli- gent Transport Systems" 185 254 W2989923758.pdf 5 5 text 0.99843466 ". The group of indicators called “Traffic Efficiency” deals with mobility defined by 14 indicators: the average duration of a road trip to the appropriate point of interest, the average duration of trips to the appropriate point of interest carried out by using the public passenger transport system, the ca-pacity/supply of the public transport system, the time required to switch between transport modes, the aver - age distance between different transport modes, the time required to access the station, the average dura - tion of a search for a parking place, the average dura - tion of the daily trips, the average distance covered by the daily trips, the total length of the road network, the coverage of the road network by ITS services, the mod - al split, the share of non-motorised trips in daily com - muting and the length of the transport network intend - ed for non-motorised trips. EYGM [51] defines the urban mobility indicators as a set of basic parameters with a potential to help the local administration with a proactive interaction with the shareholders of the mo - bility ecosystem. The framework consists of three indi - cator groups: city structural factors, mobility infrastruc - ture and demographics. During the Civitas project and within the tool for the integrated mobility planning, Stantchev and Rye [52] have defined six groups of the key personal mobility indicators related to public transport, car ownership, average travel time, traffic volume and vehicle status. The social indicators in- clude urban density, space consumption, public trans - port availability, traffic related injuries and fatalities." 254 1923 W2989923758.pdf 5 6 separator 0.8656904 ¶ 1924 1926 W2989923758.pdf 5 7 text 0.9992257 "The economic indicators are related to the fuel price, GDP per capita and space consumption in terms of the transport infrastructure. The environmental indicators involve greenhouse gas emissions, CO 2 and CH4, NO2 and noise emissions. Barker et al. [50] analyse the sustainability of the transport system and mobility. The indicators are defined in terms of travel time i.e. con - gestion, transport-generated expenditure, casualties of traffic accidents, energy consumption and polluting emissions. The key indicator is the number of vehicle – kilometres. Costa et al. [7] define a set of measures for the sustainable urban mobility monitoring. The pro- cess of the indicator selection included several phases, where 465 mobility indicators were defined in the first phase. The second phase encompassed categorisa - tion and grouping, thus resulting in a reduced list of 115 indicators, organised in categories and themes. The categories are transport and environment, infra- structure and transport technology, spatial planning and transport demands and socio-economic aspects of transport. The final list is narrowed down to 24 indi - cators. Within the Conduits project [15, 20], the au - thors Kaparis and Bell have defined a set of indicators" 1926 3229 W2989923758.pdf 5 8 separator 0.9946042 ¶ 3230 3232 W2989923758.pdf 5 9 title 0.9113103 Table 2 – An overview of the transport indicators [4, 6, 7, 15, 20, 47-49] 3232 3307 W2989923758.pdf 5 10 separator 0.99165225 ¶ 3307 3309 W2989923758.pdf 5 11 table 0.9917675 "Transport indicators Unit Transport indicators Unit Average distance covered by daily trips km Quantity of trips vehicle/h Average daily trip duration per person h Number of trips number Average trip duration per kilometre h Travel time h Average trip duration per vehicle h Travel purpose % Total number of passenger and ton kilometres pkm/tkmAverage travel time using public transport system to the desired point of interesth Reliability factor 0-1Capacity/supply of public passenger transport systemnumber of passenger seats Average travel time using road network to the desired point of interesthTime required to switch between transport modesh Average vehicle speed km/hAverage distance between transport modeskm Average freight transport speed km/h Station access time h Road network length km Public transport services per inhabitanttrips per inhabitant Length of the transport network intended for non-motorised trips.km Modal split % Coverage of the road network with ITS services %Average duration of a search for a parking placeh Traffic volume (Passenger Car Equivalent) PCE Congestions in the transport system h Road capacity vehicle/h Delays in the transport system h Quantity of trips vehicle/kilometres vehicle/km" 3309 4587 W2989923758.pdf 5 0 title 0.98263663 INTRODUCTION 0 12 W3169256945.pdf 1 1 separator 0.9960295 ¶ 12 14 W3169256945.pdf 1 2 text 0.9995676 "From 2002 to 2018, the number of patients with prostate cancer significantly increased from 679,023 to 1276,106 worldwide (Parkin et al., 2005 ;Torre et al., 2015 ;Bray et al., 2018 ). Total prostatectomy (including robot-assisted prostatectomy), radiationtherapy, and pharmacological treatment are commonly used totreat prostate cancer. Additionally, the ef ficacy and safety of various drug therapies including hormones and antiandrogenic drugs, aswell as chemotherapeutics, have been investigated in variousstudies; the results have prompted the clinical use of thesetherapies in an effort to improve prostate cancer treatment(National Comprehensive Cancer Network, 2018 ). Meanwhile, androgen receptor antagonists including enzalutamide and apalutamide have been recently developed. The major adverse effects of these drugs include fatigue, skin rash, hypothyroidism,pruritus, and weight loss. Convulsive seizures, heart problems, andsevere skin disorders have been reported as serious adverse effects(Astellas, 2018 ;Janssen Pharmaceutical, 2019 ). These agents inhibit not only the binding of androgens to androgen receptorsbut also their nuclear translocation, thereby suppressing the growthof androgen-dependent tumors, leading to the development ofcastration-resistant, castration-free, distant metastasis-free, andandrogen-dependent tumors ( Clegg et al., 2012 ). Therefore, these antagonists have been indicated for patients with prostate cancer, and they are expected to improve treatment ef ficacy ( Clegg et al., 2012 ;Smith et al., 2018 )." 14 1588 W3169256945.pdf 1 3 separator 0.9344765 ¶ 1588 1590 W3169256945.pdf 1 4 text 0.99970037 "These drug therapies may elicit an array of adverse effects including interstitial lung disease (ILD), which is a serious drug-induced adverse effect with no known mechanism of onset. Theaverage survival time of patients with ILD is 28 –52 months from the con firmation of diagnosis, according to European and American reports, and 61 –69 months from the time of initial diagnosis, according to Japanese reports ( The Japanese Respiratory Society, 2020 ). An investigation based on the opinion of an expert committee of the Pharmaceutical and Consumer Health Bureau of the ( Ministry of Health, Labor, and Welfare, 2019 )of Japan, on November 15, 2019, reported serious adverse effects associated with administration of Erleada ® (apalutamide) 60 mg tablet, launched in May 2019, wherein thecausal relationship with ILD could not be ruled out. However, onedeath, following the administration of Erleada ®(60 mg tablets), was associated with an undeniable causal relationship to ILD. Inresponse, the Ministry of Health, Labour and Welfare ’s Pharmaceutical Affairs and Consumer Health Bureau instructedThe Chief of the Pharmaceutical Safety Division, that is, theFederation of Pharmaceutical Manufacturers ’Associations of Japan (FPMAJ), to revise the package inserts of ethical drugs associated with serious adverse effects (Director of Of fice of Safety Division, Pharmaceutical Safety and EnvironmentalHealth Bureau, 2019). Considering that the incidence ofantiandrogen-induced ILD is not known, any drug suspected toinduce lung injury should be discontinued promptly, regardless ofthe adverse event severity. If the treatment cannot be discontinued,the patient should be switched to another type of drug that is lesslikely to have the same adverse events. However, antineoplastictherapy should not be resumed until the patient ’s lung injury hasimproved ( Kohno et al., 1993 ;Ohnishi et al., 2003 ;The Japanese Respiratory Society, 2020 )." 1590 3567 W3169256945.pdf 1 5 separator 0.98654926 ¶ 3567 3569 W3169256945.pdf 1 6 text 0.9997289 "The resulting changes included the addition of “interstitial lung disease ”to the “serious adverse reactions ”section of the package inserts for enzalutamide and apalutamide, with the revision of the associated warnings. However, there have been no large-scaleevaluations of the potential complications of enzalutamide,apalutamide, and other antiandrogens that are currently used.Furthermore, the circumstances associated with ILD occurrenceremain unclear. Although the cause of ILD is unknown, diversegenetic backgrounds, chronic in flammations, and repeated alveolar epithelial damages induced by environmental factors have beenproposed as causative factors. Smoking is considered the mostimportant “risk factor ”that may not be a direct cause of ILD but has an indirect effect, particularly in patients with idiopathic pulmonary fibrosis (IPF). Dust exposure, which is an obvious cause, is an exclusionary condition for IPF. Although there areseveral reports on genetic polymorphisms that are highlyresponsive to environmental factors, including these risk factors,hereditary interstitial pneumonia is distinguished as familialpulmonary fibrosis. Abnormalities in genes related to surfactant proteins and their release mechanisms are associated with familialpulmonary fibrosis ( Raghu et al., 2011 ). It would be useful to investigate both newly approved drugs and older drugs using datafrom the Japanese Adverse Drug Event Report (JADER) databaseand FDA Adverse Event Reporting System (FAERS) for detecting rare adverse events such as ILD ( Fukazawa et al., 2018 ;Raschi et al., 2021). Therefore, in the current study, we investigated the potential association between the reporting of ILD and antiandrogen drugusage in clinical practice by conducting a survey of reports in theJADER database, published by the Pharmaceuticals and MedicalDevices Agency. Data from the JADER and FAERS, published bythe United States Food and Drug Administration (FDA), were usedto determine the reporting odds ratios (RORs) to detect adverseevent signals for the evaluation of relationships betweenantiandrogens and ILD." 3569 5696 W3169256945.pdf 1 7 separator 0.99608386 ¶ 5696 5698 W3169256945.pdf 1 8 title 0.9923988 MATERIALS AND METHODS 5698 5720 W3169256945.pdf 1 9 separator 0.9962375 ¶ 5720 5722 W3169256945.pdf 1 10 text 0.99964434 "Data from the JADER database were downloaded from thePharmaceuticals and Medical Devices Agency (PMDA) website(https://www.pmda.go.jp/, accessed on March 4, 2020). The JADERdatabase consists of four files: DEMO, DRUG, REAC, and HIST. The DEMO file contains basic information about patients, including sex, age, and weight. The DRUG file contains information about the drug, such as the generic name, route of administration, and start and end dates of administration. The REAC fil ec o n t a i n st h en a m eo fa d v e r s e events, their outcomes, and the date of occurrence. The HIST file contains information on the primary disease of patients(Supplementary Table S1 ,Supplementary Table S2) ." 5722 6427 W3169256945.pdf 1 11 separator 0.96276915 ¶ 6427 6429 W3169256945.pdf 1 12 text 0.99763554 "The FAERS database, downloaded from the FDA website (http://www.fda.gov/ accessed on January 8, 2020) comprisedseven files, namely, DEMO, DRUG, REAC, OUTC, RPSR, INDI, and THER. The DEMO file contains basic information about patients, including sex, age, date of adverse event, and countryof occurrence of the adverse event. 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B 81, 115407 (2010). 2998 3180 W2898942710.pdf 7 42 separator 0.85070896 ¶ 3180 3182 W2898942710.pdf 7 43 bibliography 0.9978777 30. Yu, R. et al. Quantized Anamolous Hall Effect in Magnetic Topological Insulators. Science 329, 61 (2010). 3183 3294 W2898942710.pdf 7 44 separator 0.8462547 ¶ 3294 3296 W2898942710.pdf 7 45 bibliography 0.997163 "31. Chang, C.-Z. et al. Experimetnal Observation of the Quantum Anomalous Hall Effect in a Magnetic Topological Insulator. Science 340, 167 (2013)." 3297 3449 W2898942710.pdf 7 46 separator 0.9899367 ¶ 3449 3451 W2898942710.pdf 7 47 title 0.96659786 Acknowledgements 3451 3468 W2898942710.pdf 7 48 separator 0.99283546 ¶ 3468 3470 W2898942710.pdf 7 49 text 0.99365354 "The authors thank W .-C. Chien for his help with the manuscript. This work is supported by the Singapore National Research Foundation (NRF), Prime Minister’s Office, under its Competitive Research Programme (NRF CRP12-2013-01, NUS Grant No. R-263-000-B30-281), the MOE-AcRF Tier-II grant MOE2015-T2-1-099 (NUS Grant No. R-380-000-012-112) and the Minister of Science and Technology of R. O. C. with the project no. 107-2112-M-002-013-MY3." 3470 3912 W2898942710.pdf 7 50 separator 0.9966521 ¶ 3912 3914 W2898942710.pdf 7 51 title 0.9780812 Author Contributions 3914 3935 W2898942710.pdf 7 52 separator 0.99321586 ¶ 3935 3937 W2898942710.pdf 7 53 text 0.9981522 Z.B.S. and J.-Y .C. performed most of the derivations and calculations. S.G.T., M.B.A.J. and C.-R.C. contributed to the discussion and analysis of the results. All authors wrote and reviewed the manuscript. 3937 4144 W2898942710.pdf 7 54 separator 0.9965513 ¶ 4144 4146 W2898942710.pdf 7 55 title 0.9444192 Additional Information 4146 4169 W2898942710.pdf 7 56 separator 0.995299 ¶ 4169 4171 W2898942710.pdf 7 57 text 0.50821805 Competing Interests 4171 4192 W2898942710.pdf 7 58 paratext 0.44978002 : 4192 4193 W2898942710.pdf 7 59 text 0.5749451 The authors declare no competing interests. 4193 4237 W2898942710.pdf 7 60 separator 0.66239554 ¶ 4237 4239 W2898942710.pdf 7 61 paratext 0.44684494 Publisher’ 4239 4250 W2898942710.pdf 7 62 text 0.42508116 s note 4250 4256 W2898942710.pdf 7 63 paratext 0.42806572 : 4256 4257 W2898942710.pdf 7 64 text 0.4441423 4257 4258 W2898942710.pdf 7 65 paratext 0.42699742 Springer 4258 4266 W2898942710.pdf 7 66 text 0.4849237 Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 4266 4376 W2898942710.pdf 7 67 separator 0.9831461 ¶ 4376 4378 W2898942710.pdf 7 68 paratext 0.9468978 "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per- mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018" 4378 5264 W2898942710.pdf 7 0 paratext 0.986177 EXPERIMENTAL AND THERAPEUTIC MEDICINE 5: 119-127, 2013 121 0 61 W1980982763.pdf 2 1 separator 0.9942516 ¶ 61 63 W1980982763.pdf 2 2 text 0.99756336 "Correlation in expression among these indicators. The correlation in expression of XPO4 between the cancerous and paracancerous liver tissue was positive (CC=0.304, P<0.001). Expression of XPO4 in the cancerous liver tissue was positively correlated with expression of TGF β1 (CC=0.126, P=0.047) in paracancerous liver tissue, expres - sion of ANGPTL4 (CC=0.506, P=0.000) in cancerous liver tissue, expression of ANGPTL4 (CC=0.199, P=0.002) in para - cancerous liver tissue and expression of elF5A2 (CC=0.194, P=0.002) in paracancerous liver tissue (Table II). The correla - tion in expression of ANGPTL4 between the cancerous and paracancerous liver tissue was positive (CC=0.282, P<0.001)." 63 785 W1980982763.pdf 2 3 separator 0.9748653 ¶ 786 788 W1980982763.pdf 2 4 text 0.9991913 "Expression of ANGPTL4 in the cancerous liver tissue was positively correlated with expression of XPO4 (CC=0.506, P<0.001) in carcinoma liver tissue, expression of elF5A2 (CC=0.469, P<0.001) in carcinoma liver tissue and expression of elF5A2 (CC=0.245, P<0.001) in paracancerous liver tissue." 788 1092 W1980982763.pdf 2 5 separator 0.94793785 ¶ 1093 1095 W1980982763.pdf 2 6 text 0.999304 "The correlation in expression of elF5A2 between cancerous and paracancerous liver tissues was positive (CC=0.371, P<0.001). Expression of elF5A2 in the cancerous liver tissue was positively correlated with expression of XPO4 (CC=0.478, P<0.001) in carcinoma liver tissue. These results suggest that the expression of these four indicators is internally connected and there is modulation between each of them." 1095 1522 W1980982763.pdf 2 7 separator 0.9965008 ¶ 1523 1525 W1980982763.pdf 2 8 title 0.98971355 "Correlation between expression of indicators and patho - logical information" 1525 1604 W1980982763.pdf 2 9 separator 0.9937465 ¶ 1604 1606 W1980982763.pdf 2 10 text 0.9992098 "Indicators and tumor size. In patients with multi-nodular tumors, the tumor samples were obtained from the largest tumor. The statistical results revealed that the expression of TGF β1 in paracancerous liver tissue was significantly posi - tively correlated with tumor size (CC=0.147, P=0.021, n=248; Table III). The other 7 parameters, e.g., TGF β1 in cancerous liver tissue, and XPO4 in cancerous liver tissue, had no signifi - cant correlation with tumor size." 1606 2089 W1980982763.pdf 2 11 separator 0.9952601 ¶ 2090 2092 W1980982763.pdf 2 12 title 0.97484016 Indicators and blood vessel invasion 2092 2129 W1980982763.pdf 2 13 text 0.99931276 "The statistical results revealed that all indicators in cancerous and paracancerous liver tissues had no significant correlation with blood vessel invasion (Table IV)." 2130 2307 W1980982763.pdf 2 14 separator 0.9855592 ¶ 2307 2309 W1980982763.pdf 2 15 text 0.9962228 "Indicators and pathological classification (differentia - tion). The patients were divided into two categories according to the Edmondson classification; high differentiation (I, II, I-II) and low differentiation (II-III, III, IV). The statistical results revealed that all indicators exhibited higher expres - sion levels in the low differentiation group than in the high differentiation group (Table V). XPO4 in cancerous liver tissue (CC=0.143, P=0.035) and TGF β1 (CC=0.195, P=0.004) in paracancerous liver tissue were significantly correlated with tumor differentiation." 2309 2909 W1980982763.pdf 2 16 separator 0.99565774 ¶ 2910 2912 W1980982763.pdf 2 17 title 0.9707052 Indicators and tumor T classification 2912 2950 W1980982763.pdf 2 18 text 0.99973464 "The statistical results revealed that expression of TGF β1 in both cancerous and paracancerous tissues (CC=0.402, P=0.000; CC=0.299, P=0.000, respectively) was positively correlated with T classification; expression of ANGPTL4 in cancerous and paracancerous liver tissues (CC=0.125, P=0.049; CC=0.142, P=0.025, respectively) was positively correlated with T clas - sification and that the expression of elF5A2 in paracancerous liver tissues (CC=0.127, P=0.047) was positively correlated with T classification." 2950 3486 W1980982763.pdf 2 19 separator 0.9951163 ¶ 3486 3488 W1980982763.pdf 2 20 title 0.6818515 Indicators and survival function 3488 3521 W1980982763.pdf 2 21 text 0.9854268 ". Kaplan-Meier analysis indicated that the expression of XPO4 in carcinoma tissue did not correlate with survival function in overexpression and underexpression (P=0.202). The survival plot indicated that survival rates in patients with XPO4 overexpression were higher than those in patients with XPO4 underex - pression (Fig. 2A). Expression of XPO4 in adjacent tissue did not correlate with overexpression or underexpression (P=0.139). The survival plot indicated that survival rates in patients with XPO4 overexpression in adjacent tissues were lower than those in patients with XPO4 underexpression." 3521 4155 W1980982763.pdf 2 22 separator 0.9671154 ¶ 4156 4158 W1980982763.pdf 2 23 text 0.9996855 "These results suggested that higher expression of XPO4 in cancerous liver tissue was indicative that the patient would have a better prognosis and increased survival rate. However, higher concentrations of XPO4 in paracancerous liver tissue suggested a worse prognosis (Fig. 2B). Furthermore, expres - sion of TGF β1 in carcinoma tissue did not correlate with overexpression or underexpression (P=0.954). The survival figure indicated that patients who were positive for TGF β1 in cancerous liver tissue had a better prognosis than those who were negative for TGF β1 in cancerous liver tissue (Fig. 3)." 4158 4788 W1980982763.pdf 2 24 separator 0.9808104 ¶ 4789 4791 W1980982763.pdf 2 25 text 0.9983926 "Other factors, e.g., ANGPTL4 and ELF, were not correlated with overexpression or underexpression in either of the cancerous and adjacent tissues." 4791 4944 W1980982763.pdf 2 26 separator 0.99577856 ¶ 4944 4946 W1980982763.pdf 2 27 title 0.98781776 Discussion 4946 4957 W1980982763.pdf 2 28 separator 0.9962765 ¶ 4958 4960 W1980982763.pdf 2 29 text 0.9973076 "In the present study, we employed multiple techniques, including the use of qPCR, immunostaining and TMAs, as well as histology and pathology analysis, to undertake a study to evaluate XPO4, TGF β1, ANGPTL4 and elF5A2 in carcinoma and paracarcinoma tissues from 280 liver cancer patients. Our results revealed that all four indicators were Table I. Expression of XPO4, TGF β1, ANGPTL4 and elF5A2." 4960 5372 W1980982763.pdf 2 30 separator 0.9926769 ¶ 5372 5374 W1980982763.pdf 2 31 table 0.9936968 "Indicator Carcinoma tissue Adjacent tissue P-valuea XPO4 0.800±0.194 0.855±0.113 0.000 TGF β1 0.256±0.284 0.502±0.312 0.000 ANGPTL4 0.723±0.247 0.817±0.173 0.000 elF5A2 0.770±0.176 0.814±0.141 0.000" 5374 5581 W1980982763.pdf 2 32 separator 0.9855218 ¶ 5581 5583 W1980982763.pdf 2 33 text 0.993803 "aPaired‐sample t‐test. P<0.05 was considered to indicate a statistically significant difference. XPO4, TGF β1, ANGPTL4 and elF5A2 expression in carcinoma tissues was significantly lower than that in adjacent tissues." 5583 5803 W1980982763.pdf 2 0 title 0.99195933 Descrip tion 0 12 W4385493880.pdf 25 1 separator 0.9967087 ¶ 12 14 W4385493880.pdf 25 2 text 0.99957657 "Holotype PIMUZ 39515 is a corroded, desert-polished specimen with a phragmocone diameter of about 46 mm (Fig. 17). It is fully septate and has about 22 chambers in the last volution. It is, at 46 mm in conch diameter, thickly pachyconic and subinvolute (ww/dm = 0.77; uw/dm = 0.25) with a strongly depressed, reniform whorl profile (ww/wh = 1.65), a very small whorl overlap zone (IZR = 0.17) and a very high coiling rate (WER ~ 2.65). The whorl profile is crescent-shaped and widest at the subangular umbilical margin. The umbilical wall is flattened and slightly oblique. The suture line extends nearly linearly across the flanks and venter." 14 676 W4385493880.pdf 25 3 separator 0.9959165 ¶ 676 678 W4385493880.pdf 25 4 title 0.9847491 Remarks 678 686 W4385493880.pdf 25 5 separator 0.9956914 ¶ 686 688 W4385493880.pdf 25 6 text 0.99949807 "Liroceras karaouii sp. nov. differs from L. vermis sp. nov. in the subangular umbilical margin and in the slightly wider umbilicus (uw/dm ~ 0.25 in L. karaouii but only uw/dm ~ 0.20 in L. vermis ). This shape of the umbilicus is also the most important distinguishing character from the other species of the genus. The pronounced umbilical margin in L. karaouii can be seen as a plesiomorphic character, which transforms from the possible evolutionary lineage from Bistrialites to Liroceras ." 688 1199 W4385493880.pdf 25 7 separator 0.9961663 ¶ 1199 1201 W4385493880.pdf 25 8 title 0.7244763 Family Ephippioceratidae 1201 1226 W4385493880.pdf 25 9 bibliography 0.88203675 Miller & Youngquist, 1949 1226 1252 W4385493880.pdf 25 10 separator 0.921134 ¶ 1252 1254 W4385493880.pdf 25 11 bibliography 0.4716985 Genus Ephippi 1254 1269 W4385493880.pdf 25 12 title 0.37441486 oceras 1269 1275 W4385493880.pdf 25 13 bibliography 0.8373381 Hyatt, 1884 1276 1288 W4385493880.pdf 25 14 separator 0.97160316 ¶ 1288 1290 W4385493880.pdf 25 15 title 0.80893326 Type species 1290 1303 W4385493880.pdf 25 16 separator 0.77598816 ¶ 1303 1305 W4385493880.pdf 25 17 bibliography 0.52432895 Nau 1305 1309 W4385493880.pdf 25 18 text 0.5233776 tilus ferratus 1309 1323 W4385493880.pdf 25 19 bibliography 0.5462505 Cox 1324 1328 W4385493880.pdf 25 20 text 0.5129087 , 1858 1328 1334 W4385493880.pdf 25 21 bibliography 0.5167162 ; original designation. 1334 1357 W4385493880.pdf 25 22 separator 0.99634063 ¶ 1357 1359 W4385493880.pdf 25 23 title 0.9874498 Diagnosis 1359 1369 W4385493880.pdf 25 24 separator 0.9957615 ¶ 1369 1371 W4385493880.pdf 25 25 text 0.9990788 "Genus of the family Ephippioceratidae with pachyconic to globular, involute conch. The first whorl is about 10 mm in diameter; the conch is rapidly increasing in height with a high coiling rate (WER usually Fig. 17." 1371 1590 W4385493880.pdf 25 26 title 0.75716484 Liroceras karaouii sp. nov.; dorsal projection, dorsal and lateral views of 1590 1667 W4385493880.pdf 25 27 caption 0.4263614 holo 1667 1672 W4385493880.pdf 25 28 title 0.44654366 type PIMUZ 1672 1682 W4385493880.pdf 25 29 separator 0.8918185 ¶ 1683 1685 W4385493880.pdf 25 30 text 0.70158625 "39515 (Karaoui Coll.) from the region south-east of Rissani; reconstruction of apertural view, dorsal and lateral views. Scale bar units = 1 mm." 1685 1833 W4385493880.pdf 25 31 separator 0.9965246 ¶ 1833 1835 W4385493880.pdf 25 32 title 0.802739 Table 7. Conch dimensions (in mm) and ratios of the holotype of Liroceras karaouii sp. nov. 1835 1930 W4385493880.pdf 25 33 table 0.7287517 1930 1931 W4385493880.pdf 25 34 separator 0.51559556 ¶ 1931 1932 W4385493880.pdf 25 35 table 0.99050945 "specimen dm ww wh uw ah ww/dm ww/wh uw/dm WER IZR PIMUZ 39515 45.9 35.5 21.5 11.4 17.8 0.77 1.65 0.25 2.67 0.17" 1932 2046 W4385493880.pdf 25 36 separator 0.9878101 ¶ 2046 2048 W4385493880.pdf 25 37 bibliography 0.58084726 KORN D. & KLUG C., Early Carboniferous nautiloids from the 2048 2107 W4385493880.pdf 25 38 paratext 0.5015603 Anti-Atlas 2107 2118 W4385493880.pdf 25 39 separator 0.5584851 2118 2119 W4385493880.pdf 25 40 paratext 0.702506 ¶ 181 2119 2124 W4385493880.pdf 25 41 separator 0.9913319 ¶ 2124 2126 W4385493880.pdf 25 0 table 0.99441993 "7876MNLI SST QQP QNLI STS-B RTE MRPC CoLA m/mm Acc Acc Acc Acc Acc Acc Mcc BERT 86.6/- 93.2 91.3 92.3 90.0 70.4 88.0 60.6 UniLM 87.0/85.9 94.5 - 92.7 - 70.9 - 61.1 XLNet 89.8/- 95.6 91.8 93.9 91.8 83.8 89.2 63.6 RoBERTa 90.2/90.2 96.4 92.2 94.7 92.4 86.6 90.9 68.0 BART 89.9/90.1 96.6 92.5 94.9 91.2 87.0 90.4 62.8" 0 326 W3034999214.pdf 5 1 separator 0.9898457 ¶ 326 328 W3034999214.pdf 5 2 title 0.6493973 "Table 2: Results for large models on GLUE tasks. BART performs comparably to RoBERTa and XLNet, suggest- ing that B" 328 446 W3034999214.pdf 5 3 text 0.34743038 ART 446 449 W3034999214.pdf 5 4 title 0.49681726 ’s uni-directional decoder layers do not 449 489 W3034999214.pdf 5 5 text 0.3900622 reduce performance 489 508 W3034999214.pdf 5 6 title 0.4583651 on 508 511 W3034999214.pdf 5 7 text 0.37562928 discrimina 511 522 W3034999214.pdf 5 8 title 0.38759238 tive 522 526 W3034999214.pdf 5 9 text 0.414193 tasks 526 532 W3034999214.pdf 5 10 table 0.3700978 . 532 533 W3034999214.pdf 5 11 separator 0.97286856 ¶ 533 535 W3034999214.pdf 5 12 table 0.9962012 "SQuAD 1.1 SQuAD 2.0 EM/F1 EM/F1 BERT 84.1/90.9 79.0/81.8 UniLM -/- 80.5/83.4 XLNet 89.0/94.5 86.1/88.8 RoBERTa 88.9/ 94.6 86.5/89.4 BART 88.8/ 94.6 86.1/89.2" 535 705 W3034999214.pdf 5 13 separator 0.97537756 ¶ 705 707 W3034999214.pdf 5 14 table 0.6876596 Table 3: 707 716 W3034999214.pdf 5 15 title 0.45865154 BART gives similar 716 735 W3034999214.pdf 5 16 table 0.48044878 results 735 743 W3034999214.pdf 5 17 title 0.4609703 to 743 746 W3034999214.pdf 5 18 table 0.45256543 XL 746 749 W3034999214.pdf 5 19 title 0.46399817 Net and 749 757 W3034999214.pdf 5 20 table 0.4097934 ¶ 757 758 W3034999214.pdf 5 21 title 0.48159307 RoBERTa on question answering. 758 789 W3034999214.pdf 5 22 separator 0.9799148 ¶ 789 791 W3034999214.pdf 5 23 text 0.99716437 "document, and permute all sentences. Although sen- tence permutation only shows significant additive gains on the CNN/DM summarization dataset, we hypothe- sised that larger pre-trained models may be better able to learn from this task. To help the model better fit the data, we disabled dropout for the final 10% of training steps. We use the same pre-training data as Liu et al. (2019), consisting of 160Gb of news, books, stories, and web text." 791 1252 W3034999214.pdf 5 24 separator 0.99674237 ¶ 1252 1254 W3034999214.pdf 5 25 title 0.9924858 5.2 Discriminative Tasks 1254 1279 W3034999214.pdf 5 26 separator 0.9961668 ¶ 1279 1281 W3034999214.pdf 5 27 text 0.99015546 "Tables 3 and 2 compares the performance of BART with several recent approaches on the well-studied SQuAD and GLUE tasks (Warstadt et al., 2018; Socher et al., 2013; Dolan & Brockett, 2005; Agirre et al., 2007; Williams et al., 2017; Dagan et al., 2006; Levesque et al., 2011)." 1281 1568 W3034999214.pdf 5 28 separator 0.7231654 ¶ 1568 1570 W3034999214.pdf 5 29 text 0.9988185 "The most directly comparable baseline is RoBERTa, which was pre-trained with the same resources, but a different objective. Overall, BART performs simi- larly, with only small differences between the models on most tasks. suggesting that BART’s improvements on generation tasks do not come at the expense of clas- sification performance." 1570 1919 W3034999214.pdf 5 30 separator 0.99672484 ¶ 1919 1921 W3034999214.pdf 5 31 title 0.9919833 5.3 Generation Tasks 1921 1942 W3034999214.pdf 5 32 separator 0.99657726 ¶ 1942 1944 W3034999214.pdf 5 33 text 0.99759656 "We also experiment with several text generation tasks. BART is fine-tuned as a standard sequence-to-sequence model from the input to the output text. During fine- tuning we use a label smoothed cross entropy loss (Pereyra et al., 2017), with the smoothing parameter set to 0.1. During generation, we set beam size as 5, remove duplicated trigrams in beam search, and tunedthe model with min-len, max-len, length penalty on the validation set (Fan et al., 2017)." 1944 2418 W3034999214.pdf 5 34 separator 0.9962455 ¶ 2418 2420 W3034999214.pdf 5 35 title 0.9885177 Summarization 2420 2434 W3034999214.pdf 5 36 text 0.99766093 "To provide a comparison with the state-of-the-art in summarization, we present results on two summarization datasets, CNN/DailyMail and XSum, which have distinct properties (Table 4)." 2434 2624 W3034999214.pdf 5 37 separator 0.9579883 ¶ 2624 2626 W3034999214.pdf 5 38 text 0.9991014 "Summaries in the CNN/DailyMail tend to resemble source sentences. Extractive models do well here, and even the baseline of the first-three source sentences is highly competitive. Nevertheless, BART outperforms all existing work." 2626 2862 W3034999214.pdf 5 39 separator 0.8290076 ¶ 2862 2864 W3034999214.pdf 5 40 text 0.99939585 "In contrast, XSum is highly abstractive, and extrac- tive models perform poorly. BART outperforms the best previous work, based on RoBERTa, by roughly 3.5 points on all ROUGE metrics—representing a signifi- cant advance in performance on this problem. Qualita- tively, sample quality is high (see x6)." 2864 3175 W3034999214.pdf 5 41 separator 0.96778643 ¶ 3175 3177 W3034999214.pdf 5 42 text 0.99931914 "We also conduct human evaluation (Table 5). An- notators were asked to choose the better of two sum- maries for a passage. One summary was from BART, and the other was either a human reference or publicly available output from the B ERTSUMEXTABSmodel." 3177 3437 W3034999214.pdf 5 43 separator 0.94637686 ¶ 3437 3439 W3034999214.pdf 5 44 text 0.9992784 "As with automated metrics, BART significantly outper- forms prior work. However, it has not reach human performance on this task." 3439 3572 W3034999214.pdf 5 45 separator 0.9959786 ¶ 3572 3574 W3034999214.pdf 5 46 title 0.97434807 Dialogue 3574 3583 W3034999214.pdf 5 47 text 0.99927974 "We evaluate dialogue response generation on C ONVAI2 (Dinan et al., 2019), in which agents must generate responses conditioned on both the pre- vious context and a textually-specified persona. BART outperforms previous work on two automated metrics." 3583 3840 W3034999214.pdf 5 48 separator 0.9942522 ¶ 3840 3842 W3034999214.pdf 5 49 title 0.9856 Abstractive QA 3842 3857 W3034999214.pdf 5 50 text 0.9995129 "We use the recently proposed ELI5 dataset to test the model’s ability to generate long free- form answers. We find BART outperforms the best pre- vious work by 1.2 ROUGE-L, but the dataset remains a challenging, because answers are only weakly speci- fied by the question." 3857 4138 W3034999214.pdf 5 51 separator 0.9967286 ¶ 4138 4140 W3034999214.pdf 5 52 title 0.985281 5.4 Translation 4140 4156 W3034999214.pdf 5 53 separator 0.9966855 ¶ 4156 4158 W3034999214.pdf 5 54 text 0.9992507 "We also evaluated performance on WMT16 Romanian- English, augmented with back-translation data from Sennrich et al. (2016). We use a 6-layer transformer source encoder to map Romanian into a representation that BART is able to de-noise into English, following the approach introduced in x3.4." 4158 4461 W3034999214.pdf 5 0 paratext 0.98879105 Cardiovascular Ultrasound 2004, 2:8 http://www.cardiovascularu ltrasound.com/content/2/1/8 0 91 W2127002292.pdf 2 1 separator 0.53014505 91 92 W2127002292.pdf 2 2 paratext 0.9044081 ¶ Page 3 of 6 92 105 W2127002292.pdf 2 3 separator 0.9892961 ¶ 105 107 W2127002292.pdf 2 4 text 0.975643 "(page number not for citation purposes)bypass grafts, in the first week after grafting, adventitial medial and neointimal thickening occurs as a conse- quence of increased shear stress, surgical preparative injury and the subsequent activation of multiple growth factor and cytokine cascades. This is associated with the infiltration of inflammatory cells, medial smooth muscle cell proliferation and migration to form a neointima [25]." 107 556 W2127002292.pdf 2 5 separator 0.9418678 ¶ 556 558 W2127002292.pdf 2 6 text 0.9996217 "Adventitial myofibroblast proliferation and extracellular matrix deposition also results in the formation of a thick neoadventitia [26]. These myofibroblasts migrate through all the layers of the vessel wall, where subsequent extracel- lular matrix deposition contributes to overall wall thick- ening [27]. A similar distribution of cytoskeletal proteins characteristic of myofibroblasts is observed in explanted human saphenous vein grafts suggesting that similar mechanisms occur in man [27]. After the first week, wall thickening in porcine vein grafts occurs largely due to extracellular matrix deposition (fibrosis) and neointimal smooth muscle cell proliferation, however this thickening plateaus after one month [26]." 558 1307 W2127002292.pdf 2 7 separator 0.98107815 ¶ 1307 1309 W2127002292.pdf 2 8 text 0.999653 "The early changes seen in the vessel wall of vein grafts are similar to those seen during vessel remodeling in athero- sclerotic coronary artery segments [19]. In normal arteries, remodeling is a homeostatic response to changes in flow and circumferential stretch, with compensatory enlargement and wall thickening normalizing shear stress and wall tension in response to higher blood pressures and flow velocities respectively. Outward remodeling in response to increased flow is largely dependent on shear- responsive endothelial production of nitric oxide and the gelatinase matrix metalloproteinases (MMPs) MMP-2 and MMP-9 [28,29]. MMPs are central to the turnover of the extracellular matrix, altering cell-cell interactions, modify-ing the extracellular milieu and permitting the movement and division of cells. Increased MMP production, with extracellular matrix degradation is a feature of the infiltra- tion of inflammatory cells as well as the migration of smooth muscle cells and myofibroblasts [30,31], and this may also contribute to the remodeling process [19]." 1309 2419 W2127002292.pdf 2 9 separator 0.9968263 ¶ 2419 2421 W2127002292.pdf 2 10 title 0.98828506 "Late changes in vein grafts: atherosclerosis and pathological remodelling" 2421 2498 W2127002292.pdf 2 11 separator 0.99383783 ¶ 2498 2500 W2127002292.pdf 2 12 text 0.9992864 "Early vein graft changes can be viewed as adaptive, how- ever they also predispose the graft to later accelerated graft atherosclerosis [32]. Several components of the extracellu- lar matrix that are abundant in diffuse fibrous intimal hyperplasia may increase the residence of atherogenic molecules, and promote the development of lipid-laden lesions [33,34]. Similarly, myofibroblasts are associated with contractile responses as part of wound healing [35] and it has been hypothesized that dissemination of these cells throughout all layers of the vein graft may be central to later inadequate or constrictive vessel remodeling [36,37]." 2500 3162 W2127002292.pdf 2 13 separator 0.97044766 ¶ 3162 3164 W2127002292.pdf 2 14 text 0.9996186 "Risk factors for, and the microscopic appearance of vein graft atherosclerosis are largely similar to those in coro- nary arteries and it is reasonable to suggest that similar pathological mechanisms are at work, however these occur over a much more rapid time course in vein grafts [1,4]. Atheromatous plaque is detected by IVUS as early as eight to ten months post grafting [38] in association with both expansive and constrictive remodelling [22] (Table 2). This is much earlier than originally suggested by angi- ography [5,6]. Early IVUS studies disagreed as to the nature of vein graft remodeling, with some studies report- ing expansive remodeling [21,38] whilst others did not" 3164 3871 W2127002292.pdf 2 15 title 0.9883699 Table 1: Early adaptive changes and neoi ntima formation in sa phenous vein grafts 3871 3953 W2127002292.pdf 2 16 separator 0.9806879 ¶ 3953 3955 W2127002292.pdf 2 17 table 0.98492765 "Study ReferenceGrafts / PatientsPre implantation to 1 month (mm2)>12 months (mm2) Lumen Wall AreaVessel CSA%wall areaLumen Plaque areaWall Area EEL area Vessel CSA % plaque area%wall area" 3955 4172 W2127002292.pdf 2 18 separator 0.84279656 ¶ 4172 4174 W2127002292.pdf 2 19 table 0.5793094 Nishi 4174 4180 W2127002292.pdf 2 20 bibliography 0.6648586 oka 4180 4183 W2127002292.pdf 2 21 table 0.47354227 4184 4185 W2127002292.pdf 2 22 bibliography 0.5347538 ¶ et al 4185 4192 W2127002292.pdf 2 23 table 0.9618505 "1996 [20]43/42 16.5 ± 5.7 7.4 ± 2.1 23.9 ± 7.3 32.3 ± 7 8.9 ± 2.7 10.0 ± 5.3 15.2 ± 5.8 18.8 ± 7.5 24.0 ± 7.8 51 ± 10 63 ± 7 ¶" 4192 4322 W2127002292.pdf 2 24 bibliography 0.58216333 Ge et al 4322 4331 W2127002292.pdf 2 25 table 0.8451363 "¶ 1999** [21]43/43 12.6 ± 4.0 – 19.0 ± 9.764.5 ± 15.5 " 4332 4393 W2127002292.pdf 2 26 separator 0.43757558 ¶ 4393 4394 W2127002292.pdf 2 27 bibliography 0.7983656 Hong et al 4394 4405 W2127002292.pdf 2 28 table 0.49472764 4406 4407 W2127002292.pdf 2 29 bibliography 0.4950536 ¶ 1999 4407 4413 W2127002292.pdf 2 30 table 0.98250526 "** [22]104/93 12.0 ± 4.2 – 3.8 ± 1.97.2 ± 4.1 – 13.9 ± 4.910.0 ± 3.0 – 20.3 ± 6.516.7 ± .9 17.8 ± 6.120.8 ± 5.1 – 24.1 ± 7.830 ± 5 – 79 ± 945 ± 5 – 83 ± 7" 4413 4591 W2127002292.pdf 2 31 separator 0.6815084 ¶ 4591 4593 W2127002292.pdf 2 32 table 0.9673859 "Higuchi et al 2002τ [16]47 16.2 ± 5.5 5.3 ± 2.0 21.6 ± 7.1 24.9 ± 5.0 12.8 ± 4.6 15.8 ± 5.2 28.8 ± 8.8 55.7 ± 6.8" 4593 4713 W2127002292.pdf 2 33 separator 0.9640143 ¶ 4713 4715 W2127002292.pdf 2 34 table 0.46400094 **values represent 4715 4734 W2127002292.pdf 2 35 text 0.39493135 range from reference segment 4734 4763 W2127002292.pdf 2 36 table 0.3419746 to 4763 4766 W2127002292.pdf 2 37 caption 0.33572802 4766 4767 W2127002292.pdf 2 38 text 0.39865533 focal 4767 4772 W2127002292.pdf 2 39 caption 0.35197705 steno 4772 4778 W2127002292.pdf 2 40 text 0.35745385 sis, τ ang 4778 4788 W2127002292.pdf 2 41 table 0.34464148 i 4788 4789 W2127002292.pdf 2 42 text 0.3475278 ographically 4789 4801 W2127002292.pdf 2 43 caption 0.3620468 normal 4801 4808 W2127002292.pdf 2 44 table 0.33543965 vein 4808 4813 W2127002292.pdf 2 45 text 0.3799988 . 4813 4814 W2127002292.pdf 2 46 table 0.35360134 Vessel 4814 4821 W2127002292.pdf 2 47 text 0.33207017 CS A 4821 4826 W2127002292.pdf 2 48 caption 0.33630198 , 4826 4827 W2127002292.pdf 2 49 table 0.3514868 ( 4827 4829 W2127002292.pdf 2 50 text 0.33475447 cross section 4829 4842 W2127002292.pdf 2 51 table 0.35462692 al area) measured by 4842 4864 W2127002292.pdf 2 52 text 0.40345514 ¶ 4864 4865 W2127002292.pdf 2 53 table 0.4003971 tracing the outer border of the whole vein graft, Wall area , Vessel CSA minus lumen 4865 4950 W2127002292.pdf 2 54 text 0.90333617 "area. Percent wall area was calculated as the wall area divided by Vessel CSA. In situ veins do not have an external elastic membrane however; arterializ ed saphenous vein grafts develop a sonolu cent zone, which has been reported to represent media. The EEL (external elastic membrane) area is measured by tracing the outer border of this sono lucent zone. Plaque area is calculated as external elastic membra ne minus lumen area. Percent pl aque area is calculated as plaque area divided by e xternal elastic membrane area; this has also been called the plaque burden . Plaque burden and percent wall are closely correlated." 4950 5589 W2127002292.pdf 2 0 paratext 0.9796685 "ARTICLE IN PRESS S0315-0860(04)00059-X/BRV AID:2460 Vol. ••• (••• ) [DTD5] P.2 (1-7)" 0 86 W2620883214.pdf 1 1 separator 0.61258674 86 87 W2620883214.pdf 1 2 paratext 0.9685109 ¶ YHMAT:m2 v 1.24 Prn:24/09/2004; 10:35 yhmat2460 by:Vita p. 2 87 149 W2620883214.pdf 1 3 separator 0.79715073 ¶ 149 151 W2620883214.pdf 1 4 paratext 0.9776581 2 F.W. Lawvere / Historia Mathematica •••(••••)•••–••• 151 206 W2620883214.pdf 1 5 separator 0.9945369 ¶ 206 208 W2620883214.pdf 1 6 text 0.9989646 "Is such a study worthwhile at this late date? The featured AMS Review [MR 2001d: 01048] of this AMS publication of A 2gives the impression that such a study is of merely historical interest. On the other hand, my colleague Stephen Schanuel and I had previously found, during an initial study of the Ausdehnungslehre , that there are several mathematical results in it which should be known to present- day mathematics, but are not." 208 648 W2620883214.pdf 1 7 separator 0.99530095 ¶ 648 650 W2620883214.pdf 1 8 title 0.98114985 Difficulties, real andalleged 650 679 W2620883214.pdf 1 9 separator 0.991086 ¶ 679 681 W2620883214.pdf 1 10 text 0.99946696 "A serious stumbling block to the study which is needed for extracting these mathematical results and developing them further has been Grassmann’s German writing style. Grassmann had criticized Hegel foranarbitraryunclarityinhisphilosophicaldiscussionofmathematicalissues;thatcriticismhasstruck manyasacaseofthepotcallingthekettleblack,sinceevenGerman-speakingmathematicsstudentshave found the language of A 1difficult. The gargantuan effortsof the translators should becomean important aid to those students as well." 681 1207 W2620883214.pdf 1 11 separator 0.87444884 ¶ 1207 1209 W2620883214.pdf 1 12 text 0.9995023 "Another stumbling block has been a mathematical misconception, which I will describe below, ema- nating from the 1894 editors’ footnotes to A 1(p. 300) (originally published with the Collected Works of Grassmann)." 1209 1427 W2620883214.pdf 1 13 separator 0.98018694 ¶ 1427 1429 W2620883214.pdf 1 14 text 0.9996538 "From the beginning it has been widely claimed that the main stumbling block is Grassmann’s philo- sophical introduction (A 1, pp. 23–43). The last half of that introduction is essentially one of the first expositionsoftherudimentaryprinciplesofwhattodaymightbecalleduniversalalgebra.Thecontentof the first half, after considerable study of the compact formulations, appears to be a simple and clear nat- uralscientist’sversionofthebasicprinciplesofdialecticalmaterialism,asappliedtotheformalsciences." 1429 1936 W2620883214.pdf 1 15 separator 0.8742459 ¶ 1936 1938 W2620883214.pdf 1 16 text 0.99946046 Nonetheless, the reputation ofGrassmann’sworkas mystical and mysteriousbecame widespread. 1938 2028 W2620883214.pdf 1 17 separator 0.57846975 ¶ 2028 2030 W2620883214.pdf 1 18 text 0.9996286 "SometimesthepopularizationofGrassmannwasnotmotivatedbyloveofgeometry,noraimedtoward clarificationoflearning,development,anduseofthatscience.ThepresumptionofthedifficultcharacterofGrassmann’sworkwasusedforother purposes." 2030 2250 W2620883214.pdf 1 19 separator 0.9824414 ¶ 2250 2252 W2620883214.pdf 1 20 text 0.9989562 "In Chicago, Paul Carus, the founder of the Open Court Publishing Company, edited The Monist from 1890 to 1919; the journalistic policy was to exploit recent scientific results (not yet widely understood by the public) to cast doubt on science and thus to rescue religious speculations from the advance of science." 2252 2571 W2620883214.pdf 1 21 separator 0.9459704 ¶ 2571 2573 W2620883214.pdf 1 22 text 0.7843266 "1InthatmilieuGrassmann’sworkbecamesubjectedtothesameabusethatwasshortlytobefall relativity and quantum mechanics." 2573 2689 W2620883214.pdf 1 23 separator 0.9634365 ¶ 2689 2691 W2620883214.pdf 1 24 text 0.99858147 "In Turin, Italy the application of the Ausdehnungslehre to geometry was already well under way in 1883byCorradoSegréand hisschool, whicheventually included Veronese,Castelnuovo, Enriques, and others as described by Aldo Brigaglia in [Rügen, pp. 155–164] ; nonetheless, in 1888 Giuseppe Peano suggested that the supposed incomprehensibility of Grassmann’s geometric calculus could be alleviated" 2691 3091 W2620883214.pdf 1 25 separator 0.9638308 ¶ 3091 3093 W2620883214.pdf 1 26 text 0.9980048 "1Thismethod,borrowednotunwittinglyfromBishopBerkeley,ledtoatortureddefinitionof“science”thatpermittedCarus toexultaftertheWorldParliamentofReligions(Chicago,1893)thatBuddhismisthe“mostscientific”ofreligions.Hisnameis wellknowntomathematiciansasthetitleofaseriesofexpositorymonographs(CarusMonographs)issuedbytheMathematicalAssociationofAmerica;thatserieshasbeenself-supportingformostofitslifeduetothemathematicalandpedagogicalvirtuesof its contents. Not so well known is the service, going well beyond the mere perpetuation of the name, in return for whichCarus’ widow provided the original seed money: at the same 1922 meeting of the Association where the grant was announced,theretiringaddressofthepresidenthadasitssolethemetheclaimthattheacceptanceofthemathematicalconceptsofinfinity, infinitesimal,andthefourthdimensionnecessitatealsotheacceptanceoftheideasofGod,individualinsignificance,andheaven." 3093 3997 W2620883214.pdf 1 0 paratext 0.9886726 Soc. Sci. 2023 ,12, 570 15 of 17 0 32 W4387568967.pdf 14 1 separator 0.98286414 ¶ 32 34 W4387568967.pdf 14 2 paratext 0.7057643 Conflicts of Interest: The authors declare no conflict of interest. 34 100 W4387568967.pdf 14 3 separator 0.9707632 ¶ 100 102 W4387568967.pdf 14 4 title 0.633981 References 102 113 W4387568967.pdf 14 5 separator 0.99061364 ¶ 113 115 W4387568967.pdf 14 6 bibliography 0.9980002 "Akkerman, Sanne, Wilfried Admiraal, Robert Jan Simons, and Theo Niessen. 2006. Considering Diversity: Multivoicedness in International Academic Collaboration. Culture & Psychology 12: 461–85. [CrossRef]" 115 320 W4387568967.pdf 14 7 separator 0.92699134 ¶ 320 322 W4387568967.pdf 14 8 bibliography 0.997894 Berelson, Bernard. 1984. Content Analysis in Communication Research . New York: Hafner Press. 322 416 W4387568967.pdf 14 9 separator 0.8417165 ¶ 416 418 W4387568967.pdf 14 10 bibliography 0.9980271 Berry, David Michael. 2011. The Computational Turn: Thinking About the Digital Humanities. Culture Machine 12: 1–22. 418 535 W4387568967.pdf 14 11 separator 0.9373958 ¶ 535 537 W4387568967.pdf 14 12 bibliography 0.9980455 Brent, Edward E., and Ronald E. Anderson. 1990. Computer Applications in the Social Sciences . Philadelphia: Temple University Press. 537 671 W4387568967.pdf 14 13 separator 0.9529526 ¶ 671 673 W4387568967.pdf 14 14 bibliography 0.9980476 "Bringer, Joy D., Lynne Halley Johnston, and Celia H. Brackenridge. 2006. Using Computer-Assisted Qualitative Data Analysis Software to Develop a Grounded Theory Project. Field Methods 18: 245–66. [CrossRef]" 673 882 W4387568967.pdf 14 15 separator 0.9734434 ¶ 882 884 W4387568967.pdf 14 16 bibliography 0.9980305 "Bröer, Christian, Gerben Moerman, Johan Casper Wester, Liza Rubinstein Malamud, Lianne Schmidt, Annemiek Stoopendaal, Nynke Kruiderink, Christina Hansen, and Hege Sjølie. 2016. Open Online Research: Developing Software and Method for Collaborative Interpretation. Forum Qualitative Sozialforschung/Forum: Qualitative Social Research 17: 3. [CrossRef]" 884 1239 W4387568967.pdf 14 17 separator 0.9682902 ¶ 1239 1241 W4387568967.pdf 14 18 bibliography 0.99159724 "Brown, David. 2002. Going Digital and Staying Qualitative: Some Alternative Strategies for Digitizing the Qualitative Research Process. Forum Qualitative Sozialforschung/Forum: Qualitative Social Research 3. 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Available online: http://dspace.uni.lodz.pl/xmlui/bitstream/handle/11089/24532/191-217-bryda. pdf?sequence=1&isAllowed=y (accessed on 23 September 2022)." 2445 2749 W4387568967.pdf 14 31 separator 0.9893979 ¶ 2749 2751 W4387568967.pdf 14 32 bibliography 0.99787116 "Bryda, Grzegorz, Martini Natalia, Gajda Joanna, and Płatek Daniel. Forthcoming. Domain Ontology. The New Method of Mapping the Field of Qualitative Research Practices . Przegl ̨ ad Socjologii Jako ́ sciowej (under final review)." 2751 2980 W4387568967.pdf 14 33 separator 0.97263646 ¶ 2980 2982 W4387568967.pdf 14 34 bibliography 0.9977496 "Cornish, Flora, Alex Gillespie, and Tania Zittoun. 2014. Collaborative Analysis of Qualitative Data. In The SAGE Handbook of Qualitative Data Analysis . London: SAGE Publications Ltd., pp. 79–93. 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Datafication Research: Mapping the Field for a Future Agenda. New Media & Society 25: 1451–69. [CrossRef]" 5646 5795 W4387568967.pdf 14 0 paratext 0.87818915 Page 7/20Table 0 14 W4247574476.pdf 6 1 title 0.6938492 1 14 16 W4247574476.pdf 6 2 separator 0.99171114 ¶ 16 18 W4247574476.pdf 6 3 title 0.96810025 Characteristics of the two groups at the baseline and end of study. 18 86 W4247574476.pdf 6 4 separator 0.99045247 ¶ 86 88 W4247574476.pdf 6 5 title 0.56503 Patients characteristics 88 113 W4247574476.pdf 6 6 table 0.99461144 "and macronutrientsIntervention group (n = 44) mean ± SDControl group(n = 44) mean ± SDP- value No.of patients(female%) 48.9 51.1 0.6 Age(year) 49.45 ± 10.1 49.42 ± 9.63 0.9 Income status (%) Good Moderate poor69.2 50.9 33.330.8 49.1 66.70.9 Education status (%) ≤ 12 grade > 12 grade62.5% 48.8%37.5% 51.2%0.3 Physical activity(Met min/week) 1989.96 ± 1163.83 1780.40 ± 1036.93 0.2 BMI (kg/m2) baseline End of trial29.51 ± 2.89 29.40 ± 2.91 P = 0.00228.53 ± 2.57 28.64 ± 2.62 P = 0.050.1 0.2 HTN duration ,(n) Less than 5 year More than 5 year30 1428 160.5 Calories (kcal/d) baseline End of trial2628.55 ± 437.36 2387.34 ± 409.61 P = 0.00012806.33 ± 874.62 2618.96 ± 362.45 P = 0.50.3 0.006 Protein(g/d) baseline End of trial83.29 ± 16.04 88.14 ± 14.71 P = 0.0577.80 ± 14.64 79.75 ± 15.67 P = 0.00010.06 0.01 Fiber (g/1000 Kcal) baseline End of trial12.40 ± 4.47 14.93 ± 4.97 P = 0.00116.61 ± 3.35 16.21 ± 0.51 P = 0.30.0001 0.07" 113 1156 W4247574476.pdf 6 7 separator 0.98608875 ¶ 1156 1158 W4247574476.pdf 6 8 text 0.8405787 Data are shown as mean ± standard deviation or number (%). 1158 1217 W4247574476.pdf 6 0 paratext 0.9899885 Architecture 2023 ,3 181 0 24 W4365513303.pdf 6 1 separator 0.9857329 ¶ 24 26 W4365513303.pdf 6 2 title 0.9906187 Table 3. Cont. 26 41 W4365513303.pdf 6 3 separator 0.99248445 ¶ 41 43 W4365513303.pdf 6 4 text 0.59714276 "Q3: What percentage do you think these factors have on the probability of occurrence of the project and on the severity of the project cost and time history? (0~100%)" 43 212 W4365513303.pdf 6 5 separator 0.889049 ¶ 212 214 W4365513303.pdf 6 6 table 0.6439337 Experts A, B, C 214 230 W4365513303.pdf 6 7 text 0.7001524 : The impact is too small to give data 230 268 W4365513303.pdf 6 8 table 0.44817066 ¶ Expert 268 277 W4365513303.pdf 6 9 text 0.560915 D: 277 280 W4365513303.pdf 6 10 table 0.5701323 Probab 280 286 W4365513303.pdf 6 11 text 0.7164198 "ility of occurrence increases by 30%, the cost increases by 20%, and the construction period increases by 20~30%" 286 400 W4365513303.pdf 6 12 separator 0.5168781 ¶ 400 402 W4365513303.pdf 6 13 text 0.8127879 Expert E: 20% increased chance of occurrence, 20 % cost and duration 402 471 W4365513303.pdf 6 14 table 0.36995584 471 472 W4365513303.pdf 6 15 text 0.92651016 ¶ Expert F: Chance of occurrence is increased by 30%, the cost is 10~20%, and the duration is 20% 472 569 W4365513303.pdf 6 16 separator 0.98699594 ¶ 569 571 W4365513303.pdf 6 17 text 0.9992629 "Through expert interviews, three additional risk factors, namely “raw material short- ages and difficulty of obtaining”, “labor shortages” and “pandemic effects leading to decreased labor productivity” were added to the aforementioned 18 risk factors. Finally, the formal questionnaire included 6 major categories: “Design and Contract”, “Owner Sup- plies”, “Finance”, “Construction”, “Management” and “Industry Environment”, totaling 21 risk factors, as shown in Figure 2." 571 1054 W4365513303.pdf 6 18 separator 0.98376447 ¶ 1054 1056 W4365513303.pdf 6 19 paratext 0.92479736 Architecture 2023 , 3, FOR PEER REVIEW 8 ¶ 1056 1100 W4365513303.pdf 6 20 separator 0.7780853 ¶ ¶ 1102 1109 W4365513303.pdf 6 21 caption 0.991392 Figure 2. Risk Factors for Construction Projects in a High in flationary environment. 1109 1194 W4365513303.pdf 6 22 separator 0.99524033 ¶ 1195 1197 W4365513303.pdf 6 23 title 0.99351555 3.1.3. Pilot Questionnaire 1197 1224 W4365513303.pdf 6 24 separator 0.9947899 ¶ 1225 1227 W4365513303.pdf 6 25 text 0.99954593 "Prior to the formal questionnaire administration, 15 pilot questionnaires were con- ducted to understand if the risk factors we re adequately explained, the content of the questionnaire was understood, and a risk fill-in-the-blank was added at the end of the questionnaire to ensure its validity and reliability." 1227 1547 W4365513303.pdf 6 26 separator 0.99713844 ¶ 1548 1550 W4365513303.pdf 6 27 title 0.9937056 3.2. Questionnaire Distribution and Collection 1550 1597 W4365513303.pdf 6 28 separator 0.99522537 ¶ 1598 1600 W4365513303.pdf 6 29 text 0.9995322 "The first part of the research questionnaire pr ovides personal information, exploring the respondent’s “work unit nature”, “job a ttributes”, and “years of experience in the con- struction industry”, and “whether they are cu rrently engaged in related work”. Part Two examines the risk of construction projects under COVID-19, including the probability of occurrence, and the cost and schedule impacts, using a 5-point scale to rate the di fferent levels of opinion, with the scale as follows: very unimportant (1), unimportant (2), ordi- nary (3), important (4), and very important (5), corresponding to the qualitative analysis values of the risk in this study." 1600 2276 W4365513303.pdf 6 30 separator 0.9493099 ¶ 2277 2279 W4365513303.pdf 6 31 text 0.99904084 "The study employed a randomized sampling method to distribute the questionnaire via both online and in-person means. The survey platform included public links, which actively invited industry professionals to part icipate. A total of 157 survey responses were obtained, and after screening for ineligible re sponses, 136 valid questionnaires were ana- lyzed, with a high valid sample recovery rate of 86.62%. The majority of respondents were from “Construction firms,” as shown in Table 4, and had diverse backgrounds and expe- rience in the construction industry. Notably, 58% of respondents had over five years of experience in the field, indicating the reliability and vali dity of the results. Therefore, the sample is considered high quality compared to previous studies related to construction in Taiwan." 2279 3113 W4365513303.pdf 6 32 separator 0.95864916 "¶ ¶" 3114 3124 W4365513303.pdf 6 33 caption 0.993078 Figure 2. Risk Factors for Construction Projects in a High inflationary environment. 3124 3208 W4365513303.pdf 6 34 separator 0.9955884 ¶ 3208 3210 W4365513303.pdf 6 35 title 0.9934663 3.1.3. Pilot Questionnaire 3210 3237 W4365513303.pdf 6 36 separator 0.9954062 ¶ 3237 3239 W4365513303.pdf 6 37 text 0.9994957 "Prior to the formal questionnaire administration, 15 pilot questionnaires were con- ducted to understand if the risk factors were adequately explained, the content of the questionnaire was understood, and a risk fill-in-the-blank was added at the end of the questionnaire to ensure its validity and reliability." 3239 3556 W4365513303.pdf 6 38 separator 0.9968495 ¶ 3556 3558 W4365513303.pdf 6 39 title 0.99369264 3.2. Questionnaire Distribution and Collection 3558 3605 W4365513303.pdf 6 40 separator 0.9959649 ¶ 3605 3607 W4365513303.pdf 6 41 text 0.99927175 "The first part of the research questionnaire provides personal information, exploring the respondent’s “work unit nature”, “job attributes”, and “years of experience in the con- struction industry”, and “whether they are currently engaged in related work”. Part Two examines the risk of construction projects under COVID-19, including the probability of oc- currence, and the cost and schedule impacts, using a 5-point scale to rate the different levels of opinion, with the scale as follows: very unimportant (1), unimportant (2) ,ordinary (3) ," 3607 4163 W4365513303.pdf 6 0 paratext 0.89842474 24:8 4 vs 7 sparse undirected unweighted Diameter is SETH-hard at time n4/3 0 75 W4297795846.pdf 7 1 separator 0.9787855 ¶ 75 77 W4297795846.pdf 7 2 math 0.9616093 "(a,b,c )(a,b,i,j,k ) (a,b,i′,j′,k′)({d,e},i,j,k ) (p1,p2,i,j,k ) (p′ 1,p′ 2,i′,j′,k′)a[i] =a[j] =a[k] =1 maj(b[i],b[j],b[k]) =1d[i] =d[j] =d[k] =e[i] =e[j] =e[k] =1 ∃h∈{i,j,k}, c[h] =b[h] =1a∈{d,e} a[p1] =b[p1] =c[p1] = a[p2] =b[p2] =c[p2] =13d[p1] =e[p2] =1 or d[p2] =e[p1] =1 TCP I (3,0)(2,3)(2,3) (0,5)" 77 415 W4297795846.pdf 7 3 separator 0.99403894 ¶ 415 417 W4297795846.pdf 7 4 caption 0.99471843 "Figure 2 The weighted construction G. In bold, the conditions for the existence of a vertex or of an edge. The edge in blue, and more generally every edge of E(T, I), has weight 3, while all other edges have weight 1. The pairs in red recall, for vertices of the corresponding set, the length of their vector tuple followed by the length of their index tuple." 417 783 W4297795846.pdf 7 5 separator 0.9922049 ¶ 783 785 W4297795846.pdf 7 6 text 0.99216145 "Proof.The first and second inclusions are actually equalities but we will not need those facts.N1[I]⊇I∪Psince every ({a,b},i,j,k )∈Pis adjacent (with an edge of weight 1) to (i,i,i,j,k )∈I. Then,N2[I]⊇N1[I∪P]⊇I∪P∪Csince every (a,b,i,j,k )∈Cis adjacent to({a,a},i,j,k )∈P. Finally,N3[I]⊇N1[I∪P∪C] =V(G)since every (a,b,c )∈Tis adjacent to (a,b,i,i,i )∈Cfor somei∈[l], for otherwise a,b,cis an orthogonal triple." 785 1204 W4297795846.pdf 7 7 separator 0.7044919 1204 1205 W4297795846.pdf 7 8 text 0.74246174 ◀ 1205 1206 W4297795846.pdf 7 9 separator 0.98426354 ¶ 1206 1208 W4297795846.pdf 7 10 text 0.9972734 "We now exhibit paths of length at most 4 between every pair of vertices of G. For the case disjunction, initially imagine the K4with loops on vertices T,C,P,I , where edges correspond to kinds of pairs that are left to check. The following paragraphs remove all its edges in the order: all edges incident to I, all remaining edges incident to PbutTP, all remaining edges incident to C, the loop on T, and finally the edge TP." 1208 1642 W4297795846.pdf 7 11 separator 0.99614286 ¶ 1642 1644 W4297795846.pdf 7 12 title 0.94733626 Betweenu∈Iandv∈V(G) 1644 1664 W4297795846.pdf 7 13 separator 0.99140865 ¶ 1664 1666 W4297795846.pdf 7 14 text 0.99913394 "AsG[I]is a clique and, by Lemma 3, N3[I] =V(G), every vertex u∈Iis at distance at most 4 from every vertex v∈V(G)." 1666 1783 W4297795846.pdf 7 15 separator 0.99307317 ¶ 1783 1785 W4297795846.pdf 7 16 title 0.7855494 Betweenu∈Pandv∈P∪C 1785 1804 W4297795846.pdf 7 17 separator 0.98579925 ¶ 1804 1806 W4297795846.pdf 7 18 text 0.99903 "For everyu∈P,N2[u]⊃Iand soN4[u]⊃P∪C, by Lemma 3. In particular there is a path of length at most 4 between uand any vertex v∈P∪C." 1806 1938 W4297795846.pdf 7 19 separator 0.9935831 ¶ 1938 1940 W4297795846.pdf 7 20 title 0.8243069 Betweenu∈Candv∈T∪C 1940 1959 W4297795846.pdf 7 21 separator 0.98820037 ¶ 1959 1961 W4297795846.pdf 7 22 text 0.99899507 "Let(a,b)be the two vector fields of u∈C,(c,d)be the first two vector fields of v∈T∪C, and ebe the third vector field of vifv∈T. Leti=ind(a,b,c,d ),j=ind(a,c,d,e )ifv∈T, and j=iifv∈C. We observe that (a,b,i,i,j ),({a,c},i,i,j ),(c,d,i,i,j )are (existing) vertices" 1961 2228 W4297795846.pdf 7