{
    "Contributors": [
        "Ishani Mondal"
    ],
    "Source": [
        "BC2GM"
    ],
    "URL": [
        "https://metatext.io/datasets/biocreative-ii-gene-mention-recognition-(bc2gm)"
    ],
    "Categories": [
        "Named Entity Recognition"
    ],
    "Reasoning": [],
    "Definition": [
        "In this task, you are given a sentence. You are expected to recognize the name of gene or protein. Although there might be several correct answers, you need to write one of them."
    ],
    "Input_language": [
        "English"
    ],
    "Output_language": [
        "English"
    ],
    "Instruction_language": [
        "English"
    ],
    "Domains": [
        "Medical Knowledge"
    ],
    "Positive Examples": [
        {
            "input": "Sox - 4 is important for very early B - cell differentiation , while TCF - 1 / LEF - 1 play a crucial role in early thymocyte development ",
            "output": "TCF - 1",
            "explanation": "The gene, TCF - 1 has been tagged as protein since it plays a crucial role in early thymocyte development."
        },
        {
            "input": "The NF - kappaB / Rel family represents one signal transduction pathway induced during such activation .",
            "output": "NF - kappaB",
            "explanation": "NF - kappaB, protein transcription factor, should be tagged."
        }
    ],
    "Negative Examples": [
        {
            "input": "Sox - 4 is important for very early B - cell differentiation , while TCF - 1 / LEF - 1 play a crucial role in early thymocyte development",
            "output": "thymocyte",
            "explanation": "Thymocytes are the immune cells present in the thymus, before it undergoes transformation into a T cell. Therefore, it should not be tagged as gene."
        },
        {
            "input": "O5257 shows homology with the SAS2 protein and another hypothetical protein from yeast .",
            "output": "protein",
            "explanation": "It is expected to return the entire phrase of SAS2 Protein as protein mention, instead of only protein."
        }
    ],
    "Instances": [
        {
            "id": "task1481-15227eef49564839b94d1f3179d27bed",
            "input": " Escherichia coli strains carrying recA730 ( or other recA * alleles ) exhibit dramatic increases in SOS - dependent spontaneous mutator activity .",
            "output": [
                "recA * alleles"
            ]
        },
        {
            "id": "task1481-91f060621ef84cf0a8fd045bb47e91ff",
            "input": " Serum IgM levels showed a highly significant increase in all types of brain tumour when compared to controls .",
            "output": [
                "Serum IgM"
            ]
        },
        {
            "id": "task1481-f9d84417f1924a33a5c233f4e172c771",
            "input": " TNF - alpha effect was eliminated by a 2 - bp substitution mutation in the NF - kappa B1 binding half site of the NF - kappa B cis element .",
            "output": [
                "TNF - alpha"
            ]
        },
        {
            "id": "task1481-3029d12bfc1045d3a2a0f56bfce81457",
            "input": " However , the molecular mechanisms by which specific cis - and trans - acting factors control activity of the prodynorphin promoter are not as clearly defined .",
            "output": [
                "prodynorphin promoter"
            ]
        },
        {
            "id": "task1481-4dcb260e0741480d9c17cc023f9a04a3",
            "input": " The nramp2 gene is comprised of 17 exons and spans more than 36 kb .",
            "output": [
                "nramp2 gene"
            ]
        },
        {
            "id": "task1481-93c145646156482e893181c30bdaf371",
            "input": " Molecular analysis indicated that inactivation of H - 2L expression in nearly every null clone resulted from an apparent deletion or rearrangement of 5 ' - flanking and 5 ' - coding H - 2L sequences , with breakpoints consistently mapping to within a 550 bp GC - rich region between exon 1 and the middle of intron 2 .",
            "output": [
                "H - 2L"
            ]
        },
        {
            "id": "task1481-7b7a44e4e690491b84d80408e90862fc",
            "input": " Similarly , TAM - 67 reverted the morphology of the AdoMetDC - antisense expressors .",
            "output": [
                "TAM - 67"
            ]
        },
        {
            "id": "task1481-c5c655ba56ae472aa755c617512dba01",
            "input": " In contrast , overexpression of the DREB2A cDNA induced weak expression of the target genes under unstressed conditions and caused growth retardation of the transgenic plants .",
            "output": [
                "DREB2A cDNA"
            ]
        },
        {
            "id": "task1481-95bd4a1f348e452e8a1cc14c56fe4c52",
            "input": " The Brassica BTH1 gene may correspond to the Arabidopsis TH - 1 gene .",
            "output": [
                "Brassica BTH1 gene"
            ]
        },
        {
            "id": "task1481-cbd10f4aa60c43c7bccf250dc72a08c2",
            "input": " The sequences of two previously known tail genes , R and S , of the temperate bacteriophage P2 and the sequence of an additional open reading frame ( orf - 30 ) located between S and V , were determined .",
            "output": [
                "tail genes"
            ]
        },
        {
            "id": "task1481-008a8a7e7a57436ba074980b97886461",
            "input": " Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor .",
            "output": [
                "p53 tumor suppressor"
            ]
        },
        {
            "id": "task1481-d27002cbac2d4212b6c08ab3b56c3028",
            "input": " Strains lacking a functional RPL16A gene grow as rapidly as wild type , whereas those containing a null allele of RPL16B grow more slowly than wild type .",
            "output": [
                "functional RPL16A gene"
            ]
        },
        {
            "id": "task1481-fb4772aafca44ed4a9a3f2739220746e",
            "input": " Treatments were two adrenocorticotrophin ( ACTH ) preparations given intramuscularly at 2 . 2 U / kg , one of the ACTH preparations given intramuscularly at 1 U / kg and a synthetic polypeptide with ACTH - like activity ( tetracosactrin , cosyntropin ) given intravenously at 5 micrograms / kg .",
            "output": [
                "ACTH - like"
            ]
        },
        {
            "id": "task1481-84172b40573e4abb9ad06a17cfc06d4b",
            "input": " UV cross - linking and Southwestern analysis suggested that KTP1 is a DNA - binding protein clearly distinct from AP2 , and this protein may be responsible for the basal keratinocyte - specific expression of the BPAG1 gene .",
            "output": [
                "BPAG1 gene"
            ]
        },
        {
            "id": "task1481-10b0deeec6d74e05b0a249502838b477",
            "input": " A role for phosphatidylinositol 3 - kinase in the regulation of beta 1 integrin activity by the CD2 antigen .",
            "output": [
                "beta 1 integrin"
            ]
        },
        {
            "id": "task1481-982fc422de8d40fbb78834e7c2756cce",
            "input": " In this respect , the promoter structure of COX genes resemble those of many house - keeping genes .",
            "output": [
                "COX genes"
            ]
        },
        {
            "id": "task1481-12d53325d2974fc78cf6feec1d4ab577",
            "input": " Developmentally - regulated interaction of a transcription factor complex containing CDP / cut with the early histone H3 gene promoter of the sea urchin Tetrapygus niger is associated with changes in chromatin structure and gene expression .",
            "output": [
                "histone H3"
            ]
        },
        {
            "id": "task1481-ef4e7c33a483461c965329eee936e14e",
            "input": " Using yeast two - hybrid screening , we isolated histone H3 as an interacting factor of CIA .",
            "output": [
                "histone H3"
            ]
        },
        {
            "id": "task1481-7368149ac4e04383b45623cdc76f1f02",
            "input": " Human alcohol dehydrogenase ( ADH ) exists as a heterogeneous group of isozymes capable of oxidizing a wide variety of aliphatic and aromatic alcohols .",
            "output": [
                "Human alcohol dehydrogenase"
            ]
        },
        {
            "id": "task1481-129dddc201454cb3a1c46c806a64991e",
            "input": " GBF1 and GBF2 mRNA is present in light and dark grown leaves as well as in roots .",
            "output": [
                "GBF2 mRNA"
            ]
        },
        {
            "id": "task1481-6942f5282b024ee2b39ab2621c6adf66",
            "input": " Diagnostic importance of determining leucine aminotransferase activity in acute pancreatitis",
            "output": [
                "leucine aminotransferase"
            ]
        },
        {
            "id": "task1481-17416b4212004bdc82057ad4f307c17b",
            "input": " The activity of platelet factor 4 in plasma of healthy and high risk newborns .",
            "output": [
                "platelet factor 4"
            ]
        },
        {
            "id": "task1481-f8f55210fb9948579da21ee395a39bf5",
            "input": " Interestingly , these \" activation - defective \" mutants segregated into two classes : 1 ) those that were unable to form dimers but that could still form higher order oligomers and transform cells , and 2 ) those that were defective for PDGF - R binding and were transformation - incompetent .",
            "output": [
                "PDGF - R"
            ]
        },
        {
            "id": "task1481-b08679637334462691b12880212aa2e2",
            "input": " This mutant also functions in vivo as a trans - acting dominant negative regulator : the transcriptional inducibility of the HIV long terminal repeat ( which contains two potential NF - kappa B binding sites ) by phorbol ester ( PMA ) is inhibited when it is co - transfected into CD4 + T cells with the delta SP mutant .",
            "output": [
                "CD4 +"
            ]
        },
        {
            "id": "task1481-af7cbad6ad514cd9a23d1159c6e94875",
            "input": " Expression of FNCAT increased on serum treatment indicating that the region of the FN gene between positions + 69 and - 510 bp mediated serum responsiveness .",
            "output": [
                "FN gene"
            ]
        },
        {
            "id": "task1481-a596803ac6b24b9faa8f004a82750d8a",
            "input": " For Thermus strain ZO5 dihydroorotase ( DHOase ; encoded by pyrC ) , the highest similarity scores ( about 40 % identity ) were obtained with DHOases from B . caldolyticus and Bacillus subtilis .",
            "output": [
                "ZO5 dihydroorotase"
            ]
        },
        {
            "id": "task1481-13589703707845029d3e8fb0b35f5757",
            "input": " Rat cholesterol side - chain cleavage cytochrome P - 450 ( P - 450scc ) gene .",
            "output": [
                "P - 450scc"
            ]
        },
        {
            "id": "task1481-3b8e27c3ac3d434fb56534a56571c1bd",
            "input": " A phase II clinical trial on MDS was conducted in a cooperative study with orally administrable ara - C analogue , PLAC , which is resistant to cytidine deaminase and had shown an anti - tumor activity on various experimental tumors by oral route .",
            "output": [
                "cytidine deaminase"
            ]
        },
        {
            "id": "task1481-555c1d422ef24a4ebf04571aa640fa5b",
            "input": " No effect of 4 beta - phorbol 12 - myristate 13 - acetate was observed on the expression of hnRNP H .",
            "output": [
                "hnRNP H"
            ]
        },
        {
            "id": "task1481-28df5f2384964f6c856221a53c0ddf5f",
            "input": " These findings suggest that NMDA receptor blockade may ameliorate the dyskinetic complications of long - term levodopa therapy , without diminishing the beneficial effects on parkinsonian signs .",
            "output": [
                "NMDA receptor"
            ]
        },
        {
            "id": "task1481-9e35e1ae734b496d9a4c62750c50b79a",
            "input": " It is concluded that the new class of competitive NMDA receptor antagonists , exemplified by CGP 37849 , is the most promising candidate for clinical trials in anxiety disorders .",
            "output": [
                "NMDA receptor"
            ]
        },
        {
            "id": "task1481-e7073055e9b94ce1b6a843833ae50ebc",
            "input": " Deletion analysis of the 7 . 3 - kb GATA - 2 promoter region revealed that a 1 . 1 - kb DNA sequence is critical for expression of GATA - 2 in neurons .",
            "output": [
                "GATA - 2"
            ]
        },
        {
            "id": "task1481-06184e4cb3774c29b2614aba47e4c867",
            "input": " However , at the time of salvage treatment , the mean serum PSA levels were 9 . 1 and 1 . 1 ng / mL for the salvage RP and salvage RT groups , respectively ( P = 0 . 0001 ) .",
            "output": [
                "serum PSA"
            ]
        },
        {
            "id": "task1481-13da79a99e3c465291ab7ba5f9d0ac37",
            "input": " Regulation of the human stress response gene GADD153 expression : role of ETS1 and FLI - 1 gene products .",
            "output": [
                "FLI - 1"
            ]
        },
        {
            "id": "task1481-2584f0f6faae436392ee19e4edc14cb4",
            "input": " Tumor necrosis factor levels were measured by enzyme - linked immunoabsorbent assay in plasma samples obtained from the hyperthermic isolated limb perfusion circuit and systemic circulation .",
            "output": [
                "Tumor necrosis factor"
            ]
        },
        {
            "id": "task1481-6b246342b0db4bdfb5abb61273ea7d72",
            "input": " The STP1 locus is located on chromosome IV close to at least two other genes involved in RNA splicing : PRP3 and SPP41 .",
            "output": [
                "STP1 locus"
            ]
        },
        {
            "id": "task1481-20c2aecd45f44861a058f14724f4cb8f",
            "input": " Also , anti - HIV gp120 and anti - CD4 crosslinking induced a 10 - 15 - fold increase in levels of both PI 3 - and PI 4 - kinase activity in anti - CD4 precipitates .",
            "output": [
                "anti - CD4"
            ]
        },
        {
            "id": "task1481-ce336662815a4f16bc8e1aef461c1ce9",
            "input": " After dialysis online , lactate was converted by means of lactate oxidase immobilized to porous glass , and the depletion of oxygen was registered by means of a Clark electrode .",
            "output": [
                "lactate oxidase"
            ]
        },
        {
            "id": "task1481-fc61042a9aa14ab89974e91b21e851e5",
            "input": " We previously described the upregulation of the MT2 antigen during urodele limb regeneration and characterized the MT2 antigen as a 310 - to 325 - kDa chondroitin - sulfated glycoprotein with a core protein of 285 - 300 kDa .",
            "output": [
                "MT2 antigen"
            ]
        },
        {
            "id": "task1481-3b54fb8c120d4057aa5b9bd1051a95f0",
            "input": " The nucleotide sequence of a PCR - amplified SMT3A genomic DNA fragment was found to be identical to that of SMT3A cDNA , indicating the absence of intron ( s ) in its protein coding region .",
            "output": [
                "SMT3A cDNA"
            ]
        },
        {
            "id": "task1481-d22d240a24874cee9c39e7fef6188c1b",
            "input": " Uncertainty exists about the function of these potential isoforms of the Cbfa1 gene .",
            "output": [
                "Cbfa1 gene"
            ]
        },
        {
            "id": "task1481-6e6835bb0ac14f8fbd462b429d8566d3",
            "input": " Liver disease and HCV infection after transplantation of organs from hepatitis C antibody positive donors .",
            "output": [
                "hepatitis C antibody"
            ]
        },
        {
            "id": "task1481-5f4d81908f8d48d486cbbd0f324d263d",
            "input": " Human epidermal growth factor ( EGF ) , a naturally occurring protein , has been implicated in the protection of gastrointestinal mucosal integrity .",
            "output": [
                "epidermal growth factor"
            ]
        },
        {
            "id": "task1481-18049c83fa2d49098faf451ffe701493",
            "input": " Furthermore , it was found that the Shb - overexpressing cells extended neurites in response to epidermal growth factor .",
            "output": [
                "epidermal growth factor"
            ]
        },
        {
            "id": "task1481-ee95a0a547e041d9a4d8e6548b1d2a58",
            "input": " Functional uncoupling of the Janus kinase 3 - Stat5 pathway in malignant growth of human T cell leukemia virus type 1 - transformed human T cells .",
            "output": [
                "Janus kinase 3"
            ]
        },
        {
            "id": "task1481-db6b902e081643be96355947c1ad2d52",
            "input": " The elevated levels of inositol phosphates resulting from N ( epi ) alpha qQ209L expression were similar to those obtained with carbachol activation of the M1 muscarinic acetylcholine receptor .",
            "output": [
                "acetylcholine receptor"
            ]
        },
        {
            "id": "task1481-a4cc8db127ed4e7fa4eb765df4058f89",
            "input": " Penicillamine - induced myasthenia gravis associated with antibodies to acetylcholine receptor .",
            "output": [
                "acetylcholine receptor"
            ]
        },
        {
            "id": "task1481-df4e8c126a7e439e920fae223322f825",
            "input": " These data suggest that weight gain or increased caloric intake , in contrast to its large effect on peripheral thyroid function , has relatively little effect on CNS TRH activity .",
            "output": [
                "CNS TRH"
            ]
        },
        {
            "id": "task1481-d756093ce5ee4a4db34f3ca4dbe1e9b8",
            "input": " The cDNA contains a reading frame for a 145 - amino - acid protein and it lacks the UGA codons , which have been found in the reading frame of the mouse MCS cDNA and have been presumed to encode the selenocysteine in the amino terminal of the deduced mouse amino acid sequence .",
            "output": [
                "mouse MCS cDNA"
            ]
        },
        {
            "id": "task1481-47ce47d427464ab989dd08b1adf2065c",
            "input": " In addition , there was an increase in the amount of p120 Ras - specific GTPase - activating protein ( GAP ) and GAP - associated p190 .",
            "output": [
                "p120 Ras"
            ]
        },
        {
            "id": "task1481-9d363c323972426e85bbf3eda670b996",
            "input": " This distinct biochemical difference between STAT5A and STAT5B was confirmed with purified activated STAT5 recombinant proteins .",
            "output": [
                "STAT5 recombinant proteins"
            ]
        },
        {
            "id": "task1481-e7d44bb6e2e04c79af4fd5ed20841b15",
            "input": " Nuclear transcription assays confirmed that cys - 3 + was under sulfur - regulated transcriptional control and that cys - 3 + transcription was constitutive in sulfur controller ( scon ) - negative regulator mutants .",
            "output": [
                "sulfur controller"
            ]
        },
        {
            "id": "task1481-be0604d55a1d40ffa0cc3c845ecb6b9e",
            "input": " Many human malignant cells lack methylthioadenosine phosphorylase ( MTAP ) enzyme activity .",
            "output": [
                "methylthioadenosine phosphorylase"
            ]
        },
        {
            "id": "task1481-11981d93447c4be29ad1768b9de59652",
            "input": " Before and 6 and 12 months after H . pylori eradication the patients were evaluated for fasting gastrinemia and pepsinogen I , basal and peak acid output , and detailed histological assessment including the ECL cell proliferative patterns .",
            "output": [
                "pepsinogen I"
            ]
        },
        {
            "id": "task1481-cea35febe0c64ecc80536642dd3c49c0",
            "input": " Cotransfection of pINV - 2473 , a construct containing 2473 base pairs of hINV upstream sequence linked to luciferase , with POU homeodomain transcription factors Oct1 , Oct2 , Brn4 , SCIP , Skn1a or Skn1i , results in a strong suppression of basal promoter activity .",
            "output": [
                "hINV upstream sequence"
            ]
        },
        {
            "id": "task1481-a1c2c645603c4e948fc1502dfaaf4776",
            "input": " Having demonstrated proper localization of GFP - calmodulin in budding yeast , we examined the localization of a fusion between GFP and calmodulin ( GFP - Camlp ) in fission yeast , where calmodulin had not been localized by any method .",
            "output": [
                "GFP - Camlp"
            ]
        },
        {
            "id": "task1481-62653ff9c6504d4495a8c1bb45f2184c",
            "input": " Thus the Hi - RARE represents a new type of RA response element with a role in the modulation of the expression of MHC class 1 family genes .",
            "output": [
                "MHC class 1"
            ]
        },
        {
            "id": "task1481-a5bce20c7a65422dbc231c717ed1c9ef",
            "input": " Serum estriol levels during beta - receptor agonist infusion in the third trimester of pregnancy .",
            "output": [
                "beta - receptor"
            ]
        },
        {
            "id": "task1481-fa7c33966bde40c4bcc93ad74b3f3209",
            "input": " Sequence analysis and electrophoretic mobility shift experiments suggest that GnSE response elements interact , in these two regions , with GATA - and LIM - related factors , respectively .",
            "output": [
                "GnSE response elements"
            ]
        },
        {
            "id": "task1481-4e6cb53534d34d208e63b334b0259430",
            "input": " A close homologue of the APK2a gene , named APK2b , was also isolated from the Arabidopsis cDNA library .",
            "output": [
                "APK2a gene"
            ]
        },
        {
            "id": "task1481-3e09405c361c4afb80ca2a56df9555f6",
            "input": " We prospectively studied serum prolactin ( PRL ) elevation after different types of documented seizures in 17 patients .",
            "output": [
                "serum prolactin"
            ]
        },
        {
            "id": "task1481-bf7cfa3d2b3b464896696b3cec9ce4f8",
            "input": " Effect of bromocriptine and metoclopramide on serum prolactin levels in patients with amyotrophic lateral sclerosis .",
            "output": [
                "serum prolactin"
            ]
        },
        {
            "id": "task1481-e1c26d5b154f49198c777d214d7f2cfc",
            "input": " The clr1 locus regulates the expression of the cryptic mating - type loci of fission yeast .",
            "output": [
                "clr1 locus"
            ]
        },
        {
            "id": "task1481-f7cb66b71ca14bb8a81ba98b28a20f69",
            "input": " Ptx1 belongs to an expanding family of bicoid - related vertebrate homeobox genes .",
            "output": [
                "bicoid - related"
            ]
        },
        {
            "id": "task1481-e83770a92226471481f4fb868162e140",
            "input": " In F9 , which is a prototype of embryonal carcinoma cells expressing hst , the expression of hst gene is positively regulated by a downstream octamer motif that functions as an enhancer .",
            "output": [
                "hst gene"
            ]
        },
        {
            "id": "task1481-510a889ca035434988d2cef1d818caa1",
            "input": " The feasibility of creating CR1 / Ig chimeras makes possible a new strategy of targeting complement inhibition by the use of Ig fusion partners having particular antigenic specificities .",
            "output": [
                "Ig fusion partners"
            ]
        },
        {
            "id": "task1481-7a453fb230074bb993807d4bafb8f882",
            "input": " 3 - 5 - fold increases in EGF receptor but not p185 ( neu ) tyrosine phosphorylation occur following Gi - coupled receptor stimulation .",
            "output": [
                "EGF receptor"
            ]
        },
        {
            "id": "task1481-3c6e3b907e2c420fa5b49fe5721bcc03",
            "input": " We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC - rich element called gERE .",
            "output": [
                "EGF receptor"
            ]
        },
        {
            "id": "task1481-cc8d064ef0784aa793412346ff9096db",
            "input": " We examined the mechanisms by which two different types of photonic radiation , short wavelength UV ( UV - C ) and gamma radiation , activate transcription factor NF - kappaB .",
            "output": [
                "NF - kappaB"
            ]
        },
        {
            "id": "task1481-18c94edfdff540bf8575d25552d400d4",
            "input": " Conversion of an NF - kappaB into a GABP binding site is likely to have occurred also during the worldwide spread of HIV - 1 , as we noticed the same LTR modification in subtype E isolates from Thailand .",
            "output": [
                "NF - kappaB"
            ]
        },
        {
            "id": "task1481-27756b2d765c4a1bb17c4cf1a1ecab3f",
            "input": " Papillomavirus type 16 oncogenes downregulate expression of interferon - responsive genes and upregulate proliferation - associated and NF - kappaB - responsive genes in cervical keratinocytes .",
            "output": [
                "NF - kappaB"
            ]
        },
        {
            "id": "task1481-14895d77a3264b459c0b61142de4f3d3",
            "input": " NF - kappaB only partially mediates Epstein - Barr virus latent membrane protein 1 activation of B cells .",
            "output": [
                "NF - kappaB"
            ]
        },
        {
            "id": "task1481-1b81c67e725b48fb9dc13a65dc9033be",
            "input": " The activation of NF - kappaB - dependent reporter gene transcription by E1A was potently suppressed upon coexpression of the E1B 19 - kDa protein ( 19K ) .",
            "output": [
                "NF - kappaB"
            ]
        },
        {
            "id": "task1481-b14becfc2afc46aebc9584982bfca326",
            "input": " These results provide strong evidence that conserved interhelical packing interactions in the gp41 core are important determinants of HIV - 1 entry and its inhibition .",
            "output": [
                "gp41 core"
            ]
        },
        {
            "id": "task1481-f452eb2cd7a448f384ffbf10ce5aaa80",
            "input": " Deletion mutants of the human CHOP promoter identify a region comprising nucleotides - 75 to - 104 required for both constitutive and ER - stress - inducible expression .",
            "output": [
                "human CHOP promoter"
            ]
        },
        {
            "id": "task1481-1b78006743174f5c89c230d522458f96",
            "input": " Both viruses express the mil / raf oncogene product as a gag - fusion polyprotein , while the myc oncogene of MH2 is expressed via a subgenomic mRNA .",
            "output": [
                "gag - fusion"
            ]
        },
        {
            "id": "task1481-396213183000464bad2cca2d0a9533f7",
            "input": " Extracellular protein kinase A as a cancer biomarker : its expression by tumor cells and reversal by a myristate - lacking Calpha and RIIbeta subunit overexpression .",
            "output": [
                "protein kinase A"
            ]
        },
        {
            "id": "task1481-2d89058ec9094957b76e4ecbc6c0d417",
            "input": " In isolated olfactory cilia certain odorants elicit a rapid and transient cAMP response , terminated by a concerted process which requires the action of two protein kinases , protein kinase A ( PKA ) and a receptor - specific kinase ( GRK3 ) ( Schleicher , S . , Boekhoff , I .",
            "output": [
                "protein kinase A"
            ]
        },
        {
            "id": "task1481-f702256580564ffaa15c54213f2eef7b",
            "input": " These proteins were detected by an antibody which recognizes the N - terminus of SRK3 and , in an F2 progeny segregating for the S3 haplotype , were only expressed in plants possessing the S3 haplotype .",
            "output": [
                "S3 haplotype"
            ]
        },
        {
            "id": "task1481-4f6a02211b7b4095a320c2505cfe0b8a",
            "input": " We present here the complete primary structure of human gp330 , the human variant of the principal kidney autoantigen causing Heymann membranous glomerulonephritis in rats .",
            "output": [
                "human gp330"
            ]
        },
        {
            "id": "task1481-8a77bff0bb044f95b77c4b7ba30dab64",
            "input": " By contrast , CIS failed to affect the IL - 9 response .",
            "output": [
                "IL - 9"
            ]
        },
        {
            "id": "task1481-97dd9321b12a4262a1accbe7c998d381",
            "input": " The human IFI16 gene is a member of an interferon - inducible family of mouse and human genes closely linked on syntenic regions of chromosome 1 .",
            "output": [
                "human IFI16 gene"
            ]
        },
        {
            "id": "task1481-ddf2a7f37f71453b91c4d31dbf481b2b",
            "input": " HNF4alpha7 mRNA is also found in totipotent embryonic stem cells .",
            "output": [
                "HNF4alpha7 mRNA"
            ]
        },
        {
            "id": "task1481-ca5973dc02ba434f882efe1fb88f6de8",
            "input": " We suggest that the responses to types I and II collagen were caused by a cross - reaction with type III collagen peptides .",
            "output": [
                "type III collagen"
            ]
        },
        {
            "id": "task1481-10a7ff8fdfac42fc95caa671225567d6",
            "input": " TAF - 1 activates transcription constitutively and was mapped to the first 32 amino acids of the A - region .",
            "output": [
                "TAF - 1"
            ]
        },
        {
            "id": "task1481-265a29102a3148e2b109b5c99c969e82",
            "input": " Genomic organization of the human multidrug resistance ( MDR1 ) gene and origin of P - glycoproteins .",
            "output": [
                "P - glycoproteins"
            ]
        },
        {
            "id": "task1481-d39997307ed34e2bb8cb814ff6cc5d0e",
            "input": " The purified RAG1 protein overexpressed in E . coli exhibited the expected cleavage activity when combined with RAG2 purified from transfected 293T cells .",
            "output": [
                "RAG1 protein"
            ]
        },
        {
            "id": "task1481-7f1768a83fe44a36992d0c4897bc271e",
            "input": " Analysis of exon 2 of the factor IX gene revealed a C - - > T mutation in codon 10 of the propeptide region , resulting in the substitution of alanine by valine .",
            "output": [
                "factor IX gene"
            ]
        },
        {
            "id": "task1481-afce2db93c694c2b9ab4255f6f4b1ef6",
            "input": " These results support an in vivo interaction between Nck and CKI - gamma2 and suggest that CKI - gamma2 could be involved in signaling pathways downstream of RTKs .",
            "output": [
                "CKI - gamma2"
            ]
        },
        {
            "id": "task1481-fc3369f6265e4db4b6ac1ee114650eb8",
            "input": " The Rep78 protein of adeno - associated virus ( AAV ) contains amino acid sequence motifs common to rolling - circle replication ( RCR ) initiator proteins .",
            "output": [
                "Rep78 protein"
            ]
        },
        {
            "id": "task1481-c60cb2901b9840a0a243335fda83d4a9",
            "input": " The gamma - GCS gene is expressed ubiquitously and induced coordinately with NAD ( P ) H : quinone oxidoreductase ( 1 ) ( NQO1 ) and glutathione S - transferase Ya ( GST Ya ) in response to xenobiotics and antioxidants .",
            "output": [
                "GST Ya"
            ]
        },
        {
            "id": "task1481-c3c3c36a8f11441aab26dc60902b89cf",
            "input": " Hence the GAP1 gene encodes a protein with characteristics typical of integral membrane proteins translocating ligants across cellular membranes .",
            "output": [
                "GAP1 gene"
            ]
        },
        {
            "id": "task1481-75bff717f66e4276af2be473ba1f7c46",
            "input": " Its activity was twice that of a construct where the CAT gene was driven by the H - 2Kb 5 ' enhancer region ( H2TF1 / KBF1 site ) and comparable to that of pRSVCAT construct carrying the strong Rous sarcoma virus LTR enhancer .",
            "output": [
                "CAT gene"
            ]
        },
        {
            "id": "task1481-4af1202f9820475491c7e28538f0b828",
            "input": " To probe the inter - relationship between the virion - anchoring function and the oligomerization function , we constructed two serotype 3 ( T3 ) sigma 1 deletion mutants in SV40 expression vectors , one lacking the hydrophobic tail and the hinge , and the other lacking an adjacent region which constituted part of the coiled - coil .",
            "output": [
                "sigma 1"
            ]
        },
        {
            "id": "task1481-516ef306c2d24be4a4b6a606a37118e2",
            "input": " The fru gene has seven exons spanning 15 - kb encoding two transcripts with ORFs of 841 and 695 amino acids .",
            "output": [
                "fru gene"
            ]
        },
        {
            "id": "task1481-56260694570346d3930ab4e9f62713e7",
            "input": " A survey of children with HBsAg markers related to their parents HBV markers .",
            "output": [
                "HBsAg markers"
            ]
        },
        {
            "id": "task1481-3b2560d55f5645ad9d1fa97b1d635eac",
            "input": " Gene expression is in part controlled by chromatin remodeling factors and the acetylation state of nucleosomal histones .",
            "output": [
                "nucleosomal histones"
            ]
        },
        {
            "id": "task1481-2123e066ae404243bab4789b7a690f77",
            "input": " We suggest that this effect of Myc is mediated by its action upstream of cyclin E - CDK2 , and occurs via the neutralization of p27 ( Kip1 ) family proteins , rather than induction of Cdc25A .",
            "output": [
                "cyclin E"
            ]
        },
        {
            "id": "task1481-274e24162fdc4f289a236abe2a9dfcee",
            "input": " Adenovirus - mediated gene transfer of MMAC1 / PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E / CDK2 complexes .",
            "output": [
                "cyclin E"
            ]
        },
        {
            "id": "task1481-153169e5c04f4b4fb0f13a1c1168f1d7",
            "input": " These three phases of cyclin E association with chromatin may facilitate the diverse activities of cyclin E - - Cdk2 in initiating replication , blocking rereplication , and allowing resetting of origins after mitosis .",
            "output": [
                "cyclin E"
            ]
        },
        {
            "id": "task1481-5ef9ac25e85d459c9435d688181d64b1",
            "input": " Most significantly , the cyclin E - Cdk2 complex is maximally active at the G1 / S transition , and overexpression of cyclin E decreases the time it takes the cell to complete G1 and enter S phase .",
            "output": [
                "cyclin E"
            ]
        },
        {
            "id": "task1481-2ce6b1e261264ad386d9a3df3bb6526c",
            "input": " When a longer - 714 to + 78 fragment of the PBGD promoter is used , the - 70 GATA mutant still displays erythroid - specific activity and is cis - activated by the 5 ' HS - 2 enhancer , while the - 100 CCACC mutant is completely inactive in the absence or in the presence of the 5 ' HS - 2 enhancer .",
            "output": [
                "PBGD promoter"
            ]
        },
        {
            "id": "task1481-7a73a0cd7cf74f0daaa1a8cc0ee27d94",
            "input": " In one trial , 116 subjects with transfusion - related chronic hepatitis C were treated with lymphoblastoid interferon ( 5 MU / m2 three times a week for 2 mo , then 3 MU / m2 three times a week for 4 or 10 mo ) .",
            "output": [
                "lymphoblastoid interferon"
            ]
        },
        {
            "id": "task1481-cf8e621dc12847e28fb4cba1aafc90b0",
            "input": " However , electron microscopy revealed that while sec4 mutant cells accumulate secretory vesicles , ypt31 / 32 mutant cells accumulate aberrant Golgi structures .",
            "output": [
                "sec4 mutant"
            ]
        },
        {
            "id": "task1481-4041cfc62f694e09ac25e2dca78c7396",
            "input": " We analyzed the effects of light on tubulin mRNA abundance in Arabidopsis seedlings using RNA gel blot hybridizations and gene - specific probes .",
            "output": [
                "tubulin mRNA"
            ]
        },
        {
            "id": "task1481-49eb2191a79546898b069b0cbcde8304",
            "input": " In turn , production of sufficient amounts of TraR apparently is sensitive to a cellular function requiring RNase D .",
            "output": [
                "RNase D"
            ]
        },
        {
            "id": "task1481-94afa7aefa164186b612d755db976674",
            "input": " 13 : 961 - 969 , 1993 ) suggested that T antigen could mediate transcriptional activation through interaction with the TATA - binding protein , as well as upstream bound transcription factors .",
            "output": [
                "T antigen"
            ]
        },
        {
            "id": "task1481-ab15c75859c8439c97c92d33d5767241",
            "input": " The gp41 peptide ( Glu - Leu - Asp - Lys - Trp - Ala ) fused to the C - terminus of Sj GST forms a loop stabilized by symmetry - related GSTs .",
            "output": [
                "Sj GST"
            ]
        },
        {
            "id": "task1481-d54fd641cce94a298dbe303c6914cf4b",
            "input": " As regards the short stature , they have proved that the syndrome is related to low levels of somatomedin C ( SmC ) .",
            "output": [
                "somatomedin C"
            ]
        },
        {
            "id": "task1481-eecdf6ab314943379752f4ad6f745bdf",
            "input": " Here we demonstrate that CD40 or IgM receptor stimulation of primary B cells results in transactivation of this enhancer .",
            "output": [
                "IgM receptor"
            ]
        },
        {
            "id": "task1481-14bee8963cfe434a93cd750a9c2b426b",
            "input": " We have previously demonstrated that pyrene in diesel - exhaust particles ( DEP ) has an adjuvant activity on immunoglobulin E ( IgE ) antibody production in mice immunized with Japanese cedar pollen allergen ( JCPA ) or ovalbumin ( OA ) intraperitoneally .",
            "output": [
                "immunoglobulin E"
            ]
        },
        {
            "id": "task1481-2499b07419904595ada716021aad53cd",
            "input": " Both RNA14 and RNA15 wild - type genes , when cloned on a multicopy plasmid , are able to suppress the temperature - sensitive phenotype of strains bearing either the rna14 or the rna15 mutation , suggesting that the encoded proteins could interact with each other .",
            "output": [
                "rna15 mutation"
            ]
        },
        {
            "id": "task1481-ed3a6419d664424db8d483e0e837814b",
            "input": " Sorting information to the chloroplastic inner envelope is contained in an NH2 - proximal part of mature IEP110 ( 110N ) .",
            "output": [
                "mature IEP110"
            ]
        },
        {
            "id": "task1481-2bd2ac69d4c2408c877a268c7cac1110",
            "input": " The requirement for an essential interaction between NPH I and H4L provides an explanation for the observed restriction of transcription termination to early viral genes .",
            "output": [
                "NPH I"
            ]
        },
        {
            "id": "task1481-4220150207d84525a663a3a05b005741",
            "input": " Using reporter gene constructs driven by the CD4 promoter , we report that HHV - 6 can efficiently transactivate such genetic elements .",
            "output": [
                "CD4 promoter"
            ]
        },
        {
            "id": "task1481-d1757d910e8b4d91a1824f186a722d99",
            "input": " Free protein S deficiency in acute ischemic stroke .",
            "output": [
                "protein S"
            ]
        },
        {
            "id": "task1481-ad41f44ce78844fdab899119c1fa2761",
            "input": " Our data define Ile ( 16 ) , Val ( 18 ) , Val ( 31 ) , and Ile ( 33 ) as crucial for protein S binding , with secondary effects from Leu ( 38 ) and Val ( 39 ) .",
            "output": [
                "protein S"
            ]
        },
        {
            "id": "task1481-94f7c8c8c84b45a782a3b0b80d4600bf",
            "input": " This activity creates a 4 - bp staggered cut with 3 ' OH overhangs within a specific sequence of the 21S rRNA gene of omega - strains .",
            "output": [
                "21S rRNA gene"
            ]
        },
        {
            "id": "task1481-517b82534bd842929cc8488e518edb94",
            "input": " Although analysis of the similarity between the 44 - kDa protein and the E . coli RecA protein did not show any significant homology between them , it revealed their identity by five amino - acid residues involved in the formation of the epitope that recognized the paratope of the RecA protein antibody for subsequent epitope - paratope binding of these proteins .",
            "output": [
                "RecA protein antibody"
            ]
        },
        {
            "id": "task1481-326d5ec97ab549d89287c1b06f90956b",
            "input": " Following EGF or NGF stimulation of the v - CrkPC12 cells , the v - Crk protein itself became tyrosine phosphorylated within 1 min .",
            "output": [
                "v - Crk"
            ]
        },
        {
            "id": "task1481-63ebe1a4168942ddb9376c9de9d3d523",
            "input": " Most interestingly , although the effector plasmid containing the ICP27 gene had little effect on its own , two different and marked effects depending on the target were observed when ICP27 was combined with ICP4 or ICP0 or both .",
            "output": [
                "ICP27 gene"
            ]
        },
        {
            "id": "task1481-b67dcb9186a74077986aa1f83037cf62",
            "input": " The hyperpigmentation is linked to the presence of numerous single melanosomes and polymelanosomes in keratinocytes at all levels of the epidermis , and in dermal Factor XIIIa - positive dendrocytes .",
            "output": [
                "Factor XIIIa"
            ]
        },
        {
            "id": "task1481-02dfdd2676f84ebca269c30dbcda5c4b",
            "input": " A p53 cDNA deletion mutant ( delta pro AE ) , which lacks this entire proline - rich domain ( deleted for amino acids 62 - 91 ) , was created and characterized for a variety of p53 functions .",
            "output": [
                "p53 cDNA"
            ]
        },
        {
            "id": "task1481-d1e790c1a2194d50b8c7161dbdda4eda",
            "input": " The goals of these experiments were to determine whether lactational anestrus would be prolonged by a 48 - h fast at days 13 and 14 postpartum ( pp ) and , if so , to determine whether this effect could be reversed by treatment with the Ob protein leptin .",
            "output": [
                "Ob protein"
            ]
        },
        {
            "id": "task1481-6a1fe310a7524deb8fe46d21a4fd2e34",
            "input": " These results demonstrate that the entire E3L gene is required for pathogenesis in the mouse model .",
            "output": [
                "E3L gene"
            ]
        },
        {
            "id": "task1481-7a682fd35bc449a4ac9dc4a71fc543d4",
            "input": " Second , overexpression of RIM11 can suppress an ime1 missense mutation ( ime1 - L321F ) but not an ime1 deletion .",
            "output": [
                "ime1 - L321F"
            ]
        },
        {
            "id": "task1481-e893494ce8a14a23be51c7b4b3d22303",
            "input": " These larger sizes , however , are consistent with predictions from the DNA sequence of the pol gene .",
            "output": [
                "pol gene"
            ]
        },
        {
            "id": "task1481-9377db37fb49489ea51864dd08caa384",
            "input": " We have isolated a unique murine FLT3 cDNA that codes for a variant isoform of FLT3 , devoid of the fifth Ig - like domain , by comparison with the prototypic form .",
            "output": [
                "murine FLT3 cDNA"
            ]
        },
        {
            "id": "task1481-0d59cf54984a4d30bcc6835cde641dd6",
            "input": " Identification of a putative chromosomal replication origin from Helicobacter pylori and its interaction with the initiator protein DnaA .",
            "output": [
                "initiator protein DnaA"
            ]
        },
        {
            "id": "task1481-280de1b8040a4b549f93956daf47d84f",
            "input": " Dual signal peptides mediate the signal recognition particle / Sec - independent insertion of a thylakoid membrane polyprotein , PsbY .",
            "output": [
                "signal recognition particle"
            ]
        },
        {
            "id": "task1481-9b0c046159384bd692d1f46f51619add",
            "input": " In vitro DNA binding assays indicate that the elements identified can specifically interact with c - Ets - 1 protein .",
            "output": [
                "Ets - 1"
            ]
        },
        {
            "id": "task1481-b5b5dad7d09f44359f50ff91e8763bc2",
            "input": " Surprisingly , although Mist1 binds to E - boxes in vivo , the Mist1 protein lacks a functional transcription activation domain .",
            "output": [
                "Mist1 protein"
            ]
        },
        {
            "id": "task1481-1d83da6914fa48a89160127cfdc7267c",
            "input": " Rat p8 mRNA was discovered because of its strong activation in pancreas during the acute phase of pancreatitis .",
            "output": [
                "Rat p8 mRNA"
            ]
        },
        {
            "id": "task1481-1d0c29dc3e17440f8d56a0610ac6bb21",
            "input": " Nuclear localization of this SNF2 - like putative helicase is dependent on a nuclear localization sequence located in the NH2 - terminal region .",
            "output": [
                "SNF2 - like"
            ]
        },
        {
            "id": "task1481-512133b1cdf5433c8a31182cc7d03e10",
            "input": " These results extend our knowledge of this SNF2 - like family member and suggest a role for PASG in leukemogenesis .",
            "output": [
                "SNF2 - like"
            ]
        },
        {
            "id": "task1481-b369b64efcf04aef89d29fd8cbacb93f",
            "input": " Steady - state levels of murine MMR mRNA were measured in the macrophage cell line J774E , which is known to express the protein at the cell surface .",
            "output": [
                "murine MMR mRNA"
            ]
        },
        {
            "id": "task1481-dbfa318b1f4b440aa6531e0f59ef737a",
            "input": " Mutation of K14 in H3 , which serves as the major target of recombinant Gcn5p acetylation in vitro , confers a strong , synthetic growth defect in gcn5 cells .",
            "output": [
                "recombinant Gcn5p"
            ]
        },
        {
            "id": "task1481-08af9acb105c4fe9b621473ad79ac11e",
            "input": " Mutational analysis of the IME2 UAS reveals two critical sequence elements : a G + C - rich sequence ( called URS1 ) , previously identified at many meiotic genes , and a newly described element , the T4C site , that we found at a subset of meiotic genes .",
            "output": [
                "IME2 UAS"
            ]
        },
        {
            "id": "task1481-3d9a5c0058394113ae50cddec38e2573",
            "input": " To determine the role of the transmembrane region of HN on fusion - promoting activity , mutant HN proteins were expressed and their biological activities examined .",
            "output": [
                "mutant HN proteins"
            ]
        },
        {
            "id": "task1481-209aa24e378342cabe200426dfa62a72",
            "input": " Soluble recombinant RI and soluble recombinant C alpha can associate in vitro and be activated by cyclic AMP .",
            "output": [
                "C alpha"
            ]
        },
        {
            "id": "task1481-c7afef74f3a64b5db5c4b544e9c846a5",
            "input": " [ ( OP ) 2Cu ] + also detected protections in the C alpha - helix , the interdomain hinge , and beta - strands 2 - 7 .",
            "output": [
                "C alpha"
            ]
        },
        {
            "id": "task1481-0ef7e91921654fa1a7f9dc3f18ee0ae1",
            "input": " Critical review of tests for the HBs antigen in the detection of infectious blood",
            "output": [
                "HBs antigen"
            ]
        },
        {
            "id": "task1481-93c6ebbe017b4fc7a33c65bf8d2b62bb",
            "input": " Overexpression of wild type and SeCys / Cys mutant of human thioredoxin reductase in E . coli : the role of selenocysteine in the catalytic activity .",
            "output": [
                "human thioredoxin reductase"
            ]
        },
        {
            "id": "task1481-c8b165f173b9414489a0c0106cd34aed",
            "input": " Legionella antibodies in domestic animals",
            "output": [
                "Legionella antibodies"
            ]
        },
        {
            "id": "task1481-2338f9dc80a7412c86350f340c649ec3",
            "input": " Despite a lowering of her plasma ACTH concentration during therapy with valproic acid , the patient ' s tumour showed no evidence of regression while she was taking the drug .",
            "output": [
                "plasma ACTH"
            ]
        },
        {
            "id": "task1481-d64d06522eef4786bb5f5e5f4cfa4369",
            "input": " Experimental studies and clinical application of plasma ACTH radioimmunoassay kit without extraction process",
            "output": [
                "plasma ACTH"
            ]
        },
        {
            "id": "task1481-f1f164a3f4ee4454b8dea67b031bb6c7",
            "input": " Peak plasma ACTH responses were not significantly different between control and patient groups .",
            "output": [
                "plasma ACTH"
            ]
        },
        {
            "id": "task1481-8b61aa3dcf0e44dd81b769e874c50349",
            "input": " Biochemical studies have identified a cellular non - P element - encoded DNA binding protein , termed the inverted repeat binding protein ( IRBP ) , that specifically interacts with the outer half of the 31 - bp terminal inverted repeats .",
            "output": [
                "P element"
            ]
        },
        {
            "id": "task1481-d545285345aa4052acdb9531bd745a7e",
            "input": " Lastly , several restriction length polymorphisms were identified and mapped within a 1 kb region located immediately upstream from the JH cluster .",
            "output": [
                "JH cluster"
            ]
        },
        {
            "id": "task1481-ff9cee5461734d558e17d3e05adccf8a",
            "input": " The uap100 cis - acting , up - promoter , constitutive mutation is a duplication that comprises two GATA sites and suppresses weakly the AREA zinc finger mutation but does not alleviate the need for functional UAY and AREA proteins .",
            "output": [
                "AREA proteins"
            ]
        },
        {
            "id": "task1481-35437c11245c4c47a24a6a86ce45be50",
            "input": " After 5 - h thermal induction of cells carrying the runaway recombinant pBS1 , protein B2 constituted 40 % of the soluble protein fraction of the cells .",
            "output": [
                "protein B2"
            ]
        },
        {
            "id": "task1481-e7fc421ab24147c6878bbe695c8c73df",
            "input": " The Valpha and Vbeta domains have the canonical features of known teleost and mammalian TCR V domains , including conserved residues in the beginning of FR2 and at the end of FR3 .",
            "output": [
                "Vbeta domains"
            ]
        },
        {
            "id": "task1481-2bb86e48f3ae4c978eb043f9431da16a",
            "input": " The corresponding tetrapeptide sequences SSPD and SATD for human and mouse PKC - epsilon , respectively , are unusual for caspase - 3 .",
            "output": [
                "caspase - 3"
            ]
        },
        {
            "id": "task1481-348f6b1136cb4fd2bf94e02946aff422",
            "input": " These results induce that the putative TATA box and initiator are not involved in the promoter activity , and that the vitronectin promoter lacks the TATA box , initiator and GC box .",
            "output": [
                "vitronectin promoter"
            ]
        },
        {
            "id": "task1481-6536c47441c3496d841bf914b613601f",
            "input": " GH signals by interacting with GH receptor ( GHR ) .",
            "output": [
                "GH receptor"
            ]
        },
        {
            "id": "task1481-fbbadef6fcce4270b12c945f1d565142",
            "input": " Therefore the effect of GAL11 on PGK transcription must be mediated at the PGK UAS , presumably as part of the activation complex .",
            "output": [
                "PGK UAS"
            ]
        },
        {
            "id": "task1481-668873f4e0724ed0894a412036cc961a",
            "input": " The P - ITIM - compelled multi - phosphoprotein complex binds to and activates SHP - 2 , which in turn dephosphorylates SHIP and Shc and probably other substrates .",
            "output": [
                "SHP - 2"
            ]
        },
        {
            "id": "task1481-b1dfeef788b746538fea49b5ae43f6ca",
            "input": " No significant difference was seen found between the two groups in the degree of postoperative deterioration in cardiopulmonary function or in interleukin - 6 levels .",
            "output": [
                "interleukin - 6"
            ]
        },
        {
            "id": "task1481-06bc88acbea44e24a7c7dd6cdabaeb89",
            "input": " Co - expression of PLD1 in COS - 7 cells with the two recombinant CK2 subunits , alpha or beta , suggests that the association of PLD1 with the kinase is through the beta subunit .",
            "output": [
                "recombinant CK2 subunits"
            ]
        },
        {
            "id": "task1481-86b2f58957fc45e29fdba67a0ca6353e",
            "input": " Low serum C3 values were observed in all 11 children at some stage of their illness .",
            "output": [
                "serum C3"
            ]
        },
        {
            "id": "task1481-e9468aea2ff94fc3afcb224941bb4c8a",
            "input": " Symptoms , skin - prick tests ( SPT ) with environmental allergens and Pt salt , total serum IgE , lung function , and bronchial hyperresponsiveness were assessed by standard procedures .",
            "output": [
                "serum IgE"
            ]
        },
        {
            "id": "task1481-4269d2d73aa647f7b56a533ce20190ad",
            "input": " Patients with the chronic photosensitivity dermatitis with actinic reticuloid syndrome have high total serum IgE concentrations .",
            "output": [
                "serum IgE"
            ]
        },
        {
            "id": "task1481-f247e82da9b44ff5ab282299261004fd",
            "input": " To further study the role of tTG in liver disease , we initiated investigations into the effect of a proinflammatory mediator , tumor necrosis factor ( TNF ) - alpha , on tTG activity in cultured liver cells .",
            "output": [
                "tumor necrosis factor"
            ]
        },
        {
            "id": "task1481-4c3be2fe44dc4da089e71b5b8d6cae1a",
            "input": " The polypeptide encoded by the cDNA contained 450 amino acids with a calculated M ( r ) of 52 , 057 , and showed significant homology with human and mouse CAD ( 22 % identity ) .",
            "output": [
                "mouse CAD"
            ]
        },
        {
            "id": "task1481-7dcb17fedaed4009a9adf1de75d35b52",
            "input": " The SEC27 gene was cloned , and the sequence predicts a 99 . 4 - kDa protein with 45 % sequence identity to mammalian beta ' - COP .",
            "output": [
                "SEC27 gene"
            ]
        },
        {
            "id": "task1481-8a4936396b8743a5be44adb94f3d7f6c",
            "input": " In contrast , dominant negative Rac ( N17Rac1 ) inhibited JNK activation by Galpha12 in HEK293 cells as well as three other cell lines .",
            "output": [
                "dominant negative Rac"
            ]
        },
        {
            "id": "task1481-5c59674006d44cd0b0fb670c3d03a9a0",
            "input": " This demonstrates the presence of a PKC - dependent pathway which functions independently from Lck in MAP kinase activation .",
            "output": [
                "MAP kinase"
            ]
        },
        {
            "id": "task1481-6258f91a25144e91a627ce02b0707c6e",
            "input": " These observations demonstrate that KSR is capable of uncoupling the MAP kinase activation from its target phosphorylation , and thus provide a novel mechanism for modulating the Ras - MAP kinase signaling pathway .",
            "output": [
                "MAP kinase"
            ]
        },
        {
            "id": "task1481-8fcaff93b2bc4dab99e7280fe3a83f47",
            "input": " Furthermore , CL100 suppresses the [ val12 ] ras - induced activation of MAP kinase in a cell - free system from Xenopus oocytes .",
            "output": [
                "MAP kinase"
            ]
        },
        {
            "id": "task1481-d174ec70a49c47509d615959318987b0",
            "input": " However , microinjection of reconstituted mRNPs into Xenopus oocytes demonstrates that although translational repression occurs in the absence of consensus RNA binding sequences for FRGY2 , the presence of FRGY2 recognition elements within mRNA potentiates translational repression .",
            "output": [
                "FRGY2 recognition elements"
            ]
        },
        {
            "id": "task1481-fab1fcbf803b4ea49a11dd37b36dfcf9",
            "input": " Effects of timepidium bromide ( TB ; anticholinergic agent ) , acetylcholine ( ACh ) and neostigmine ( Neost ) on gastric and duodenal blood flow distribution were studied by the use of 131I - labeled macroaggregated human serum albumin ( MAA ) in rabbits .",
            "output": [
                "serum albumin"
            ]
        },
        {
            "id": "task1481-3e4dcc22350f4edf940f6ba457ee2943",
            "input": " Recombinant caspases are typically produced in Escherichia coli expression systems with the attendant problems of solubilization , re - folding and activation of the protease .",
            "output": [
                "Recombinant caspases"
            ]
        },
        {
            "id": "task1481-aefd0ceaf6d440089fa108909068477a",
            "input": " PC12 cultures that had been \" primed \" in this way showed an accelerated and augmented differentiation response to nerve growth factor .",
            "output": [
                "nerve growth factor"
            ]
        },
        {
            "id": "task1481-6ae316bb00fd4d93bca0eff06987f7f8",
            "input": " The best - studied neurotrophin , nerve growth factor ( NGF ) , is a major survival factor in sympathetic and sensory neurons and promotes differentiation in a well - studied model system , PC12 cells .",
            "output": [
                "nerve growth factor"
            ]
        },
        {
            "id": "task1481-52c6da873f6d4d1994ccfab8bcf48c8d",
            "input": " The yeast genome contains a single ORD1 gene that resides on chromosome XI .",
            "output": [
                "ORD1 gene"
            ]
        },
        {
            "id": "task1481-6ca014eef0c549b1a9809049fbdd4c2a",
            "input": " When targeted to the GAL1 promoter by fusing with the Gal4p DNA - binding domain , Sko1p acts as an Ssn6 / Tup1p - dependent repressor regulated by osmotic stress .",
            "output": [
                "GAL1 promoter"
            ]
        },
        {
            "id": "task1481-b994a6da53a3426395db5908e7043d18",
            "input": " An X - linked zinc finger gene mapping to Xq21 . 1 - q21 . 3 closely related to ZFX and ZFY : possible origins from a common ancestral gene .",
            "output": [
                "zinc finger gene"
            ]
        },
        {
            "id": "task1481-e475ae69f3b440b3a71a688ffd4ff12e",
            "input": " The myeloid zinc finger gene 1 ( MZF1 ) encodes a C ( 2 ) H ( 2 ) zinc finger transcription factor that regulates granulopoiesis and may have a regulatory role in cellular proliferation and oncogenesis .",
            "output": [
                "zinc finger gene"
            ]
        },
        {
            "id": "task1481-e4add23fef80497db6adcf3756eda1d0",
            "input": " In addition , wild - type and mutated DNA templates were used as probes in DNase I protection experiments to determine sites of protein - DNA interaction .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-537a9860e3b64e92a6102b48f7ef99dd",
            "input": " DNase I protection analysis as well as oligonucleotide competition experiments indicate that this binding is sequence specific .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-e6f208a2009b4c5892ff288d0d6e4e77",
            "input": " Moreover , such mutations lead to a dramatic transition in chromatin structure : the DNase I hypersensitive region is replaced by two stable , sequence - positioned nucleosomes .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-89624fd8aa1e4d1892bbf53ca2a43dc9",
            "input": " The human SHBG proximal promoter was analyzed by DNase I footprinting , and the functional significance of 6 footprinted regions ( FP1 - FP6 ) within the proximal promoter was studied in human HepG2 hepatoblastoma cells .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-2a7cdba3036d4fe0912af8a4aec0c591",
            "input": " In this work , we determined the sequences of eight VirF - binding sites from four different genes , by DNase I or hydroxyl radical footprinting .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-e64e21acd8a9448c8905dda8ecb904ed",
            "input": " A 360 - bp DNA fragment located over 500 bp upstream from the cfl transcriptional start site was used in DNase I protection assays to define the specific bases bound by CorR .",
            "output": [
                "DNase I"
            ]
        },
        {
            "id": "task1481-b7584c73fc5c47429b42bf9574f4c74e",
            "input": " Nonlethal sec71 - 1 and sec72 - 1 mutations eliminate proteins associated with the Sec63p - BiP complex from S . cerevisiae .",
            "output": [
                "sec71 - 1"
            ]
        },
        {
            "id": "task1481-0e761a2c5189423fa60f765e24167bfe",
            "input": " On the other hand , NE transport and antagonist ( [ 125I ] RTI - 55 ) binding assays on whole LLC - NET cells treated with tunicamycin reveal a pronounced reduction in NE transport activity and hNET membrane density paralleled by an inability of NET proteins to replenish the higher M ( r ) hNET pool .",
            "output": [
                "NET proteins"
            ]
        },
        {
            "id": "task1481-dbd15d1e1d3e4bc395bcacdf4f2e64bd",
            "input": " The structure of the murine Dtk gene has been determined .",
            "output": [
                "murine Dtk gene"
            ]
        },
        {
            "id": "task1481-45c1676e90b54d55b5e31993f61bb6c5",
            "input": " The distinct spatial pattern of expression , and unusual amino acid sequence in its DNA binding domain , may indicate a particular role for DTEF - 1 in cell - specific gene regulation .",
            "output": [
                "DTEF - 1"
            ]
        },
        {
            "id": "task1481-06ed4b5de2c944cdbbeac78a6476e580",
            "input": " Long - range mapping by pulse - field gel electrophoresis indicated that the three mdr genes are closely linked on a genomic DNA segment of approximately 625 kilobases .",
            "output": [
                "mdr genes"
            ]
        },
        {
            "id": "task1481-27a14ea0860b48f0bd379c11f7998dd3",
            "input": " Multiple aortic thrombi associated with protein C and S deficiency .",
            "output": [
                "protein C"
            ]
        },
        {
            "id": "task1481-4bedff0474bb41adbe3f3dc61c19f4d1",
            "input": " The adoption of a twisted structure of importin - beta is essential for the protein - protein interaction required for nuclear transport .",
            "output": [
                "importin - beta"
            ]
        },
        {
            "id": "task1481-17af0dc50e2a45e18071871f43df1927",
            "input": " Antibodies specific to the different members of the Jun and Fos family of transcription factors show that , in gel retardation assays , a Jun - like factor is a component of the H3 . 2 specific complex .",
            "output": [
                "Fos family"
            ]
        },
        {
            "id": "task1481-abfe38e3c0e045bca34b67905308f4e5",
            "input": " The D443N substitution is an activating mutation that increases the activity of SCAP and renders it resistant to inhibition by 25 - hydroxycholesterol .",
            "output": [
                "D443N substitution"
            ]
        },
        {
            "id": "task1481-811632fee1e84045abea77ff639014ca",
            "input": " We have utilized transient transfections , mutation analysis , electromobility gel - shifts , and immunoblot analysis to test the hypothesis that expression of the CTalpha gene is controlled in part by the binding of three trans - acting nuclear factors , Sp1 , Sp2 , and Sp3 .",
            "output": [
                "CTalpha gene"
            ]
        },
        {
            "id": "task1481-70f0b1ac42df4238b3527970de844427",
            "input": " PtdIns ( 4 , 5 ) P2 synthesis , on the other hand , is only moderately affected even in fab1Delta mutants .",
            "output": [
                "fab1Delta mutants"
            ]
        },
        {
            "id": "task1481-3cd6d049e251400aad22157b63644237",
            "input": " A 4 . 0 - kb Nlk message is also present during embryogenesis , detectable at day E10 .",
            "output": [
                "Nlk message"
            ]
        },
        {
            "id": "task1481-e20b24dabf8e43c389c54433fd57dc7a",
            "input": " The atopic disposition , indicated by positive skin reactions and IgE antibody titers etc . , and the bronchial reactivity to inhaled acetylcholine were examined on the following three groups : ( 1 ) 20 young adults with a history of childhood asthma who have been symptom - free for more than 4 yr ; ( 2 ) 20 current asthmatics , and ( 3 ) 20 healthy young adults .",
            "output": [
                "IgE antibody"
            ]
        },
        {
            "id": "task1481-224b7b405668446d96166e12dfd369e6",
            "input": " IgE antibody to twelve common food and inhalant allergens was measured by enzyme - linked immunosorbent assay ( ELISA ) in the sera of thirteen atopic patients with one or more allergic disorders ( asthma occurring in eleven ; rhinitis in ten ; eczema in six ; urticaria in four ; mouth and gastro - intestinal symptoms in six ) , of twelve non - atopic patients with various clinical symptoms ( asthma in four ; rhinitis in four ; eczema in one ; urticaria in two ; mouth and gastro - intestinal symptoms in four ) and sixteen cord blood sera .",
            "output": [
                "IgE antibody"
            ]
        },
        {
            "id": "task1481-57978dcdc8724252ac60289fb0d142d6",
            "input": " Uncoupling gene activity from chromatin structure : promoter mutations can inactivate transcription of the yeast HSP82 gene without eliminating nucleosome - free regions .",
            "output": [
                "yeast HSP82 gene"
            ]
        },
        {
            "id": "task1481-ad717dd3003e488fb8fb25a0293f7cdf",
            "input": " The PK domain showed pairwise in vitro binding interactions with the pseudokinase , HisRS , and C - term domains ; additionally , the HisRS domain interacted with the C - term region .",
            "output": [
                "HisRS domain"
            ]
        },
        {
            "id": "task1481-ab4cf9ae712b42cc885b9bc39cdfc15d",
            "input": " A conventional N - terminal signal sequence was not detected in the NodO protein .",
            "output": [
                "NodO protein"
            ]
        },
        {
            "id": "task1481-4047614839e44deba8e0e7588e3c888a",
            "input": " This study was undertaken to evaluate the physical and biological characteristics of nebulized interleukin 2 liposomes .",
            "output": [
                "interleukin 2"
            ]
        },
        {
            "id": "task1481-5932a8ebcae54dc18efb4ab7e97d23fd",
            "input": " Promoter activity of the proliferating - cell nuclear antigen gene is associated with inducible CRE - binding proteins in interleukin 2 - stimulated T lymphocytes .",
            "output": [
                "interleukin 2"
            ]
        },
        {
            "id": "task1481-8e920f4fd8f2441dab4163b4ff461f2b",
            "input": " We were unable to construct chvI or chvG insertion mutants of R . meliloti , whereas mutants carrying insertions outside of these genes were readily obtained .",
            "output": [
                "chvG insertion mutants"
            ]
        },
        {
            "id": "task1481-04ddc0885853411f8a673ec0f0467a7f",
            "input": " Plasma LH and progesterone levels after single or multiple injections of synthetic LH - RH in anoestrous ewes and comparison with levels during the oestrous cycle .",
            "output": [
                "Plasma LH"
            ]
        },
        {
            "id": "task1481-eead9e69682c49aaa21428609c006a64",
            "input": " First , a GATA - 1 motif was found to bind nuclear factor ( s ) , presumably the GATA - 1 factor , present in K - 562 cell extracts and in living K - 562 cells .",
            "output": [
                "GATA - 1"
            ]
        },
        {
            "id": "task1481-9b8c54f5b57e4015bfcac9dafa1fa15e",
            "input": " ES cells in which the gene for the erythroid transcription factor GATA - 1 has been disrupted fail to produce mature erythroid cells either in vivo or in vitro .",
            "output": [
                "GATA - 1"
            ]
        },
        {
            "id": "task1481-ef2825630ea24d4e9a931416a33080fb",
            "input": " We have now isolated cDNA for an invertebrate Pax - 6 protein from sea urchin embryos .",
            "output": [
                "Pax - 6"
            ]
        },
        {
            "id": "task1481-2dda84620b594c10bf408e54e70e0439",
            "input": " Pax - 6 constructs lacking the C - terminal activation domain repressed betaB1 - crystallin promoter activity as effectively as the full - length protein , but the PD alone or Pax - 6 ( 5a ) , a splice variant with an altered PD affecting its DNA binding specificity , did not .",
            "output": [
                "Pax - 6"
            ]
        },
        {
            "id": "task1481-a6880a633ef543b4a91ccd7291e19a95",
            "input": " Several reports assert that prolactin affects the delta 5 and delta 4 pathways through its effect on the activity of 3beta - hydroxysteroid dehydrogenase ( 3beta - OHSD ) .",
            "output": [
                "3beta - OHSD"
            ]
        },
        {
            "id": "task1481-e604be592bf445bbbe3116c4735eb6eb",
            "input": " Located between the 3 ' trans - spliced leader acceptor site and the translational initiation codon of the GP63 gene is an area of conserved hexanucleotide direct repeats ( CTCGCC ) which vary in number according to species .",
            "output": [
                "GP63 gene"
            ]
        },
        {
            "id": "task1481-386d63e56c734816b46ce39db0c14488",
            "input": " Platelet factor 4 levels in patients with coronary artery disease .",
            "output": [
                "Platelet factor 4"
            ]
        },
        {
            "id": "task1481-18c26329760140729aff2d89996862e7",
            "input": " Electron microscopic visualization of the general population of active genes in flies overexpressing hnRNP proteins also indicated that the great majority of genes seemed normal in terms of cotranscriptional RNA processing events , although there were a few abnormalities consistent with rare exon - skipping events .",
            "output": [
                "hnRNP proteins"
            ]
        },
        {
            "id": "task1481-885e5928cf674ba1be905f50c0b25dee",
            "input": " These data show that tyrosine phosphorylation by FES affects the interaction of BCR with multiple signaling partners and suggest a general role for BCR in non - receptor protein - tyrosine kinase regulation and signal transduction .",
            "output": [
                "tyrosine kinase"
            ]
        },
        {
            "id": "task1481-c63ee89574274cf38acdd9484a0174a9",
            "input": " The model of the complex provides a rationale for conserved ITAM residues , substrate specificity , and suggests that substrate binds only the active conformation of the Src family tyrosine kinase , unlike the ATP cofactor , which can bind the inactive form .",
            "output": [
                "tyrosine kinase"
            ]
        },
        {
            "id": "task1481-bb5d0f045a1c47cb8383d9b69dd7d987",
            "input": " For the P transcript from phage with the G ( - ) orientation , full termination activity required both the region containing the stem - loop structure and upstream sequences .",
            "output": [
                "P transcript"
            ]
        },
        {
            "id": "task1481-b8a0df93129e45d59bfddd2a757c707d",
            "input": " The STS sequence WI - 14920 is in fact derived from the 3 ' - untranslated region of the human PUNC gene .",
            "output": [
                "human PUNC gene"
            ]
        },
        {
            "id": "task1481-93899bfa9755486fad9155e83324040c",
            "input": " There are two regulatory regions between the US3 and the US6 transcription units .",
            "output": [
                "US6 transcription units"
            ]
        },
        {
            "id": "task1481-c1705bf56f15443fad9b25896869cc80",
            "input": " In the virus - infected cells , translation of the M1 protein was reduced to 10 to 20 % of that of the wild - type virus ; however , the translation of neither the nucleoprotein nor NS1 was significantly interfered with , indicating the important role of NS1 in translational stimulation of the M1 protein .",
            "output": [
                "M1 protein"
            ]
        },
        {
            "id": "task1481-0a8d65c2af3645d38e62abc991c217d0",
            "input": " The association of I - 92 with p92 , p84 , p75 , p73 , p69 , and p57 was completely reversible after treatment with the detergent deoxycholate ( DOC ) .",
            "output": [
                "I - 92"
            ]
        },
        {
            "id": "task1481-bffe3f893af04fcfb25d7c2df22c9583",
            "input": " Further , we find that the BMI1 protein can also interact with itself .",
            "output": [
                "BMI1 protein"
            ]
        },
        {
            "id": "task1481-1085abcd462449be979cc260b19aa7d2",
            "input": " To obtain information on the functional role of the Rac1 / p38 / MAPKAPK - 2 pathway in RA signaling , the effects of pharmacological inhibition of p38 on RA - induced gene transcription and cell differentiation were determined .",
            "output": [
                "MAPKAPK - 2"
            ]
        },
        {
            "id": "task1481-a59fbabc6d0d486c9bf3a939ced1b80c",
            "input": " Both PMP20 gene products contain the carboxyl - terminal sequence AKL , similar to the putative SKL peroxisomal sorting sequence ( Gould , S .",
            "output": [
                "PMP20 gene products"
            ]
        },
        {
            "id": "task1481-76bee5b66cb8453a9a493d7e1e57c899",
            "input": " The effect of the NMDA - receptor antagonist ( + / - ) - CPP on the conditioned - reflex activation of an operant reaction in the brain electrical self - stimulation test in rats",
            "output": [
                "NMDA - receptor"
            ]
        },
        {
            "id": "task1481-b04734a93e3e4766aa7925faa524ada8",
            "input": " Evidence that the AT1A receptor activates transcription factor - Stat91 and / or a related protein .",
            "output": [
                "AT1A receptor"
            ]
        },
        {
            "id": "task1481-9d550a2f99a540ac899923bd963315c5",
            "input": " These data suggest that reduction in PRA may have contributed to the hemodynamic effects of this peak III PDE inhibitor .",
            "output": [
                "peak III PDE"
            ]
        },
        {
            "id": "task1481-c4247873ad304293a60ea3d0ff4b438e",
            "input": " Profilins IIa and IIb are also present in humans , suggesting that all mammals have three profilin isoforms .",
            "output": [
                "profilin isoforms"
            ]
        },
        {
            "id": "task1481-1ac2794a274542e6b870a121f8568fce",
            "input": " We have produced the Ure2 protein to high yield in Escherichia coli from a synthetic gene .",
            "output": [
                "Ure2 protein"
            ]
        },
        {
            "id": "task1481-556efc12d30c404380d08bc20df82d6e",
            "input": " Injection of horseradish peroxidase ( HRP ) into the cerebellar flocculus of the rat was employed to identify neurons in the abducens nucleus that project to the flocculus .",
            "output": [
                "horseradish peroxidase"
            ]
        },
        {
            "id": "task1481-84348e1f49674f27ae45814d207cf184",
            "input": " The electron spin resonance study also demonstrated that the formation of superoxide - DMPO spin adduct was strongly inhibited by a selective cyclooxygenase - 2 inhibitor , etodolac , in a concentration - dependent manner .",
            "output": [
                "cyclooxygenase - 2"
            ]
        },
        {
            "id": "task1481-416a834104bf4761813383524d088f77",
            "input": " BACKGROUND : Murine Nramp is a candidate for the macrophage resistance gene Ity / Lsh / Bcg .",
            "output": [
                "Murine Nramp"
            ]
        },
        {
            "id": "task1481-873d9a9d20434ea5a17ddf59eb959956",
            "input": " Plasma prolactin concentrations in pinealectomized ewes receiving melatonin treatment and in pineal intact ewes maintained under a non - 24 - hour photoperiod .",
            "output": [
                "Plasma prolactin"
            ]
        },
        {
            "id": "task1481-ca68e3e2f6374cb4905dc44953ecad94",
            "input": " Plasma prolactin in patients with colorectal cancer .",
            "output": [
                "Plasma prolactin"
            ]
        },
        {
            "id": "task1481-39228737df6a4fbf81811f23fd7d593b",
            "input": " Plasma prolactin concentrations during incubation , 25 . 8 + / - 2 . 3 ng / ml , decreased to baseline levels , 10 . 8 + / - 1 . 9 ng / ml , within 24 hr after nestbox removal .",
            "output": [
                "Plasma prolactin"
            ]
        },
        {
            "id": "task1481-bc7daf0645f443d18a3f93f3c0429ea0",
            "input": " HBO had marked effects on these enzymes : lung SOD increased ( guinea pigs 47 % , rats 88 % ) and CAT and GSHPx activities decreased ( 33 % ) in brain and lung .",
            "output": [
                "lung SOD"
            ]
        },
        {
            "id": "task1481-0e2c3682f1fa453c93e00317aa55d7ad",
            "input": " Serum C3 was measured in 1 , 282 school children with abnormal urinary findings between 1980 and 1997 .",
            "output": [
                "Serum C3"
            ]
        },
        {
            "id": "task1481-3edd4fba06014adca8cf6728824dd2f6",
            "input": " Finally , the conservation of the two residues most sensitive to mutations ( Y949 and Y953 ) in TM11 , and in the homologous TM5 , of all mammalian P - gps and also in other ABC transporters , suggests that these residues and domains may play an important role in structural as well as mechanistic aspects common to this family of proteins .",
            "output": [
                "ABC transporters"
            ]
        },
        {
            "id": "task1481-16a2038270d4458293716e4072eab4bb",
            "input": " This cell line expresses productively rearranged immunoglobulin genes as well as the Oct - 2 gene at high levels which are comparable to those observed in activated murine splenic B cells .",
            "output": [
                "immunoglobulin genes"
            ]
        },
        {
            "id": "task1481-e8d4b9165a244edc9ba3c74b308fb9d2",
            "input": " The glucose effect on the pyruvate kinase gene is reversibly antagonized by agents increasing intracellular cAMP .",
            "output": [
                "pyruvate kinase gene"
            ]
        },
        {
            "id": "task1481-ba7f60e659de4389ae0a4ade3a5d836f",
            "input": " The cause for the increase in plasma ANP levels in the active phase remains to be determined .",
            "output": [
                "plasma ANP"
            ]
        },
        {
            "id": "task1481-e5e733908f10439cafdd1d29e5c2a85b",
            "input": " Dominant - negative upf1 mutations were isolated following in vitro mutagenesis of a plasmid containing the UPF1 gene .",
            "output": [
                "UPF1 gene"
            ]
        },
        {
            "id": "task1481-4522e1347fe6474b9f15ae8d20808f24",
            "input": " The strongly DNA binding p50 subunit showed only very weak , if any , induction of gene expression .",
            "output": [
                "p50 subunit"
            ]
        },
        {
            "id": "task1481-52394295cd7d4a30ad41494621622b4b",
            "input": " The majority of putative TSC2 mutations were found in sporadic rather than TSC2 - linked families .",
            "output": [
                "TSC2 mutations"
            ]
        },
        {
            "id": "task1481-04d33440d1b64a009135a4c54eb885b9",
            "input": " In contrast , a similar fusion protein ( hGH - LDLR - DAF17 , abbreviated HLD ) containing a fragment of the serine / threonine - rich domain of the LDL receptor ( LDLR ) in place of the DAF - derived serine / threonine - rich sequences , does not become GPI anchored .",
            "output": [
                "LDL receptor"
            ]
        },
        {
            "id": "task1481-4587fe8eecbe471a9f69b68fcabcd49d",
            "input": " The classic sterol regulatory cis element ( sre - 1 ) in the LDL receptor promoter mediates sterol regulatory element binding protein ( SREBP ) - binding and the effects of insulin and platelet derived growth factor ( PDGF ) .",
            "output": [
                "LDL receptor"
            ]
        },
        {
            "id": "task1481-9cfc9543d9bd4a958a48cb1d27a6ae6c",
            "input": " Interleukin - 1 increased the noradrenaline release .",
            "output": [
                "Interleukin - 1"
            ]
        },
        {
            "id": "task1481-bc8bf944700a488792eafb0165d32ad2",
            "input": " It was found that on the 14th and 21st day after cimetidine administration serum gastrin levels were significantly elevated .",
            "output": [
                "serum gastrin"
            ]
        },
        {
            "id": "task1481-577601200b314a9f9059d66d6f9b6691",
            "input": " Selective upper abdominal sympathectomy increased basal acid output in rats but was without effect on stimulated acid output , serum gastrin concentration , and gastric mucosal histidine decarboxylase activity .",
            "output": [
                "serum gastrin"
            ]
        },
        {
            "id": "task1481-6e5ea369b844464694a2f940e9cfe5b5",
            "input": " Developmental regulation of expression of the malate synthase gene in transgenic plants .",
            "output": [
                "malate synthase gene"
            ]
        },
        {
            "id": "task1481-353de938f3e748fcbf1d1417b1fe12d6",
            "input": " CAT assays demonstrated that overexpression of RXRalpha conferred the best RA response , consistent with our previous observation that 9 - cis - RA is more potent than all - trans - RA for inducing the expression of the AFP gene .",
            "output": [
                "AFP gene"
            ]
        },
        {
            "id": "task1481-fdf285f662594c2bb082a588c21373aa",
            "input": " The more severe the CRF , the more likely that total HDL and HDL2 cholesterol will be low .",
            "output": [
                "HDL2 cholesterol"
            ]
        },
        {
            "id": "task1481-778f012c1b5d4987a650d0b6eaece70f",
            "input": " Consistent with this , rh5 expression in R8 disappears when R7 cells are absent ( in sevenless mutant ) .",
            "output": [
                "sevenless mutant"
            ]
        },
        {
            "id": "task1481-13104c726ea74953b8ffb1e1fecfaedb",
            "input": " Footprints on the HPV 18 enhancer show five protected regions with homologies to NF1 , AP1 and EFII transcription factor binding motifs .",
            "output": [
                "HPV 18 enhancer"
            ]
        },
        {
            "id": "task1481-fc599943ed3c45869266c0a0cd5e1451",
            "input": " These Tlr family members , unlike others reported to date , were identified within a genomic database .",
            "output": [
                "Tlr family members"
            ]
        },
        {
            "id": "task1481-514b1f84c02649ff84b1627f8335d0b6",
            "input": " Although polyubiquitin chains linked through Lys ( 29 ) of ubiquitin have been implicated in the targeting of certain substrates to proteasomes , the signaling properties of these chains are poorly understood .",
            "output": [
                "polyubiquitin chains"
            ]
        },
        {
            "id": "task1481-702f34d5d2744ed7a9d365828d247126",
            "input": " These results suggest that repetitive GAA sequences enhance splicing by binding a protein complex containing a sequence - specific RNA binding protein and a general splicing activator that , in turn , recruit additional SR proteins .",
            "output": [
                "SR proteins"
            ]
        },
        {
            "id": "task1481-95d239f116ea4ba8ab39e6c855346525",
            "input": " To understand this dramatic effect , we examined the localization of SR proteins and found that SC35 was shifted to the cytoplasm in sky1Delta yeast , although this phenomenon was not obvious with ASF / SF2 , indicating that nuclear import of SR proteins may be differentially regulated by phosphorylation .",
            "output": [
                "SR proteins"
            ]
        },
        {
            "id": "task1481-e65b6d866fb04ac093a8a4a0dc55b02f",
            "input": " Glutathione reductase activities in liver , kidney , lung , and brain were not affected by diet .",
            "output": [
                "Glutathione reductase"
            ]
        },
        {
            "id": "task1481-c367ee75feb5424cb4fdf411417284d9",
            "input": " Glutathione reductase ( GR ) was purified from the cyanobacterium Anabaena PCC 7120 .",
            "output": [
                "Glutathione reductase"
            ]
        },
        {
            "id": "task1481-3bdbd465c8934b1a806fbff0cae87926",
            "input": " Avian EMILIN was extracted from 19 - day - old embryonic chick aortas and associated blood vessels and purified by ion - exchange chromatography and gel filtration .",
            "output": [
                "Avian EMILIN"
            ]
        },
        {
            "id": "task1481-7a949bbcb1ac46b1bb5c88d3f374eee6",
            "input": " Recently , we demonstrated that platelet - derived growth factor ( PDGF ) - beta receptor stimulation , but not various other growth factors , inhibits transcription of alpha1D - , but not alpha1A - or alpha1B - ARs , resulting in reduced norepinephrine - mediated SMC growth .",
            "output": [
                "alpha1B - ARs"
            ]
        },
        {
            "id": "task1481-9c1b15075c5543e6879a79befff8fadd",
            "input": " Increased TRE DNA binding failed to lead to increased transactivation correlating with the inability of SB 203580 to increase phosphorylation of these AP - 1 proteins .",
            "output": [
                "AP - 1"
            ]
        },
        {
            "id": "task1481-44cfa49016964fa6825427187a83a266",
            "input": " Using a GTP - dependent , brefeldin A - sensitive in vitro AP - 1 binding assay , we have determined here the parameters of the AP - 1 binding reaction .",
            "output": [
                "AP - 1"
            ]
        },
        {
            "id": "task1481-e628da904ec742c3990cd31ffc01b2ef",
            "input": " Electromobility shift analysis using oligonucleotides encompassing the proximal , distal , and BED / AP - 1 - binding regions failed to demonstrate selective transactivation after CD2 signaling of LPMC .",
            "output": [
                "AP - 1"
            ]
        },
        {
            "id": "task1481-9759d70f3c964a53a734d30bed460f92",
            "input": " DESIGN : Activating protein - 1 ( AP - 1 ) and Tat - induced transcription were assessed using Jun and hybrid Tat / Jun - expression plasmids and reporter gene constructs which contained AP - 1 binding sites upstream of the rat prolactin TATAA element or an HIV - 1 LTR construct in which AP - 1 binding sites replaced the TAR element .",
            "output": [
                "AP - 1"
            ]
        },
        {
            "id": "task1481-b983ff022b1b490ea5f030788e4263f0",
            "input": " The RHO1 gene encodes a homolog of the mammalian RhoA small GTP - binding protein in the yeast Saccharomyces cerevisiae .",
            "output": [
                "RHO1 gene"
            ]
        },
        {
            "id": "task1481-85f73608ef8a4792a5e779acce0d970e",
            "input": " This latter complex reacts with an antibody to serum response factor ( SRF ) and exhibits the same binding characteristics as purified SRF .",
            "output": [
                "serum response factor"
            ]
        },
        {
            "id": "task1481-e1a5d1df99bf4b9b9ee40e4d7f83497c",
            "input": " Moreover , our recent findings on the Tc52 encoding gene underline the interest of genetic manipulation of T . cruzi , not only making it possible to use more closely an in vitro approach to find out how genes function , but also to obtain ' attenuated ' strains that could be used in the development of vaccinal strategies .",
            "output": [
                "Tc52 encoding gene"
            ]
        },
        {
            "id": "task1481-dbeed3ce1d0342d3acdaf7ff051c3c35",
            "input": " Differential transcription of plastome - encoded genes in the mesophyll and bundle - sheath chloroplasts of the monocotyledonous NADP - malic enzyme - type C4 plants maize and Sorghum .",
            "output": [
                "malic enzyme"
            ]
        },
        {
            "id": "task1481-a3621f97aae04be0b72d1eb48939123f",
            "input": " The delta Mo + SV tumor DNAs from B - lineage tumors were typically rearranged at the immunoglobulin gene loci and contained germ line configurations of the T - cell receptor beta gene .",
            "output": [
                "immunoglobulin gene loci"
            ]
        },
        {
            "id": "task1481-53e222f988f14113ba51ba38b187f9ba",
            "input": " But if one equalizes the upper limits of normal for both markers to a common 95 % specificity , the tumour - indicating sensitivity of CA 19 - 9 clearly surpasses that of CA 50 .",
            "output": [
                "CA 50"
            ]
        },
        {
            "id": "task1481-1ff0689c768f4484a3393c6be66290e8",
            "input": " Decreased plasma level of antithrombin III was assumed to be one of the major factors underlying hypercoagulable state in nephrotic syndrome .",
            "output": [
                "antithrombin III"
            ]
        },
        {
            "id": "task1481-dbb5df4a0ea74ac5bef273500ce292b7",
            "input": " It is pathogenetically proved to use antithrombin III concentrate preparations with anti - and dysaggregatory properties , fibronectin preparations , trasylol or its analogs during complex preoperative preparation of patients .",
            "output": [
                "antithrombin III"
            ]
        },
        {
            "id": "task1481-4442319482ca458eb52c084f7fab8bc9",
            "input": " The immunoreactive antithrombin III increased significantly while the increase in antithrombin III activity was insignificant in 20 male Caucasian Danes upon 3 weeks supplementation of the diet with 10 ml daily of a cod liver oil concentrate .",
            "output": [
                "antithrombin III"
            ]
        },
        {
            "id": "task1481-ca2c09c0cfdf4ae098def0a2a508ddff",
            "input": " Fulminant hepatic failure in these cases could be characterized by : ( 1 ) rapid decrease in serum alanine transaminase ( ALT ) level after discontinuation of ecarazine , ( 2 ) prolonged jaundice despite discontinuation of ecarazine , ( 3 ) high incidence of anti - nuclear antibody ( ANA ) ( 57 % ) , and ( 4 ) histological findings of extensive hepatocellular necrosis ranging from bridging necrosis to massive necrosis .",
            "output": [
                "serum alanine transaminase"
            ]
        },
        {
            "id": "task1481-b7ec3b3333774a0d955c54ff3e51d060",
            "input": " The detergent - solubilized complex oxidizes caldariella quinol at high rates and is completely inhibited by cyanide and by quinolone analogs , potent inhibitors of quinol oxidases .",
            "output": [
                "quinol oxidases"
            ]
        },
        {
            "id": "task1481-aef09690129a4c8494bc90e5648dd3c0",
            "input": " Serum creatinine kinase activity was 7 , 800 - 17 , 500 U / l , making acute muscle damage likely , probably rhabdomyolysis .",
            "output": [
                "creatinine kinase"
            ]
        },
        {
            "id": "task1481-986a2807f2af46c29f55d8588f110c9c",
            "input": " Radioimmunoassay of plasma gonadotropins ; problems of specificity",
            "output": [
                "plasma gonadotropins"
            ]
        },
        {
            "id": "task1481-3162164e337c43228d2a72b06bbb7c17",
            "input": " This difference between SP - 1 and SP - 2 peptides was not due to their differential uptake by cell , since approximately 100 times more SP - 2 peptide could be found in cytoplasmic extracts than SP - 1 peptide in experiments using radiolabeled peptides .",
            "output": [
                "SP - 1"
            ]
        },
        {
            "id": "task1481-71dbf752fba24d158d47a115b2234e46",
            "input": " The immediate 5 ' - flanking region was GC - rich with 3 SP - 1 - like and 2 AP - 2 sites identified in close proximity to the transcription start site .",
            "output": [
                "SP - 1"
            ]
        },
        {
            "id": "task1481-4f12bbce4e9b420faa8051a82f802e92",
            "input": " The shift from complex I to complex II seen only in SCM - 1 - producer T cell lines upon activation was completely suppressed by cyclosporin A .",
            "output": [
                "SCM - 1"
            ]
        },
        {
            "id": "task1481-5e0d42d5ce0e4d478aabec516d5b6a58",
            "input": " In contrast , postmitotic neurons possessed extremely low levels of E2F1 protein as assessed by the electrophoretic mobility shift assay and Western blotting .",
            "output": [
                "E2F1 protein"
            ]
        },
        {
            "id": "task1481-42a1912e0fce4ab282de9b5909a1fdd3",
            "input": " In contrast to the p16 - mediated G1 block , G1 arrest mediated by the cdk inhibitors p21Cip1 or p27Kip1 cannot be bypassed either by inactivation of pRb or overexpression of E2F family members .",
            "output": [
                "E2F family members"
            ]
        },
        {
            "id": "task1481-238bc875dad54523ab8279beb8aceae3",
            "input": " Site - directed mutagenesis shows that sites throughout the IRE alter negative control and IRE - BP binding reflecting the fact that the footprint of the IRE - BP is over the entire IRE .",
            "output": [
                "IRE - BP"
            ]
        },
        {
            "id": "task1481-e128dd604b3e4b00a2720fac740aa788",
            "input": " Our results showed that the 5 - hydroxytryptamine ( 5 - HT ) content in platelets was : ( 1 ) increased in the subgroup of anti - social alcoholics ; ( 2 ) transiently and differently altered in alcoholics compared to opiate addicts ; and ( 3 ) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking ( that may occur via MAO - B inhibition by smoke ) .",
            "output": [
                "MAO - B"
            ]
        },
        {
            "id": "task1481-5b9b5d03e829406caf332b0f53feb8f8",
            "input": " The sequence of LZ321 matched that of RREB1 , a transcription factor that bound to a Ras responsive element ( RRE ) very different from the sequence with which we isolated LZ321 .",
            "output": [
                "Ras responsive element"
            ]
        },
        {
            "id": "task1481-a75675f965534146ab87c6062198defa",
            "input": " Protease digestion and alkaline extraction of microsomes containing labeled mutant proteins further showed that segment 3 was sufficient for stable membrane anchoring of the glycoproteins , indicating that this segment may specify the transmembrane domain of the gB glycoprotein .",
            "output": [
                "gB glycoprotein"
            ]
        },
        {
            "id": "task1481-6516a7ead0824e9e9b06837ea103b341",
            "input": " The WEB2 gene encodes a 1 , 522 - amino - acid protein with homology to nucleic acid - dependent ATPases .",
            "output": [
                "WEB2 gene"
            ]
        },
        {
            "id": "task1481-ce7c39b5065f4413927f142d5ac51ad2",
            "input": " Genomic Southern blot analysis suggests that the human haploid genome contains a single Gs alpha gene .",
            "output": [
                "Gs alpha gene"
            ]
        },
        {
            "id": "task1481-085bbbfab8ee4171827cc6f1e16e2585",
            "input": " The encoded 260 - amino - acid ( aa ) ( H1 - I ) and 240 - aa ( H1 - II ) polypeptides possess the typical tripartite organization of animal H1 histones , with variable N - and C - terminal domains flanking a conserved ' globular ' DNA - binding domain .",
            "output": [
                "animal H1 histones"
            ]
        },
        {
            "id": "task1481-7b5acb6a17e6422a8eebfbd8c4c24af1",
            "input": " Immunoprecipitation of cell lysates with anti - phosphotyrosine and immunoblotting showed phosphorylated forms of the mitogenic pathway proteins Shc and MAPK in addition to p185 ( neu ) , suggesting that the Ras to MAPK mitogenic pathway is activated .",
            "output": [
                "anti - phosphotyrosine"
            ]
        },
        {
            "id": "task1481-fd61c80c85aa48fe9cf6d76e4ea02344",
            "input": " The Polycomb group proteins are involved in maintenance of the silenced state of several developmentally regulated genes .",
            "output": [
                "Polycomb group proteins"
            ]
        },
        {
            "id": "task1481-2235750544ab47ec9452f8f15c99920b",
            "input": " These results suggest that both the distinct DNA binding properties of PMLRAR homodimers and the sequestration of RXR by PMLRARs may contribute to the molecular mechanisms which underlie the pathogenesis of APL .",
            "output": [
                "PMLRAR homodimers"
            ]
        },
        {
            "id": "task1481-b736db16c654456aa3e94fc6989e65ad",
            "input": " Serum amyloid A ( SAA ) is a plasma protein which has been associated with several diseases , including amyloidosis , arthritis , and atherosclerosis , and its abnormal expression , particularly in nonhepatic cells , is implicated in the pathogenesis of these diseases .",
            "output": [
                "Serum amyloid A"
            ]
        },
        {
            "id": "task1481-cd8f64f2340849ca974d3268d8ef81a1",
            "input": " Together , these results implicate Fal1p in the 18S rRNA maturation pathway rather than in translation initiation .",
            "output": [
                "18S rRNA"
            ]
        },
        {
            "id": "task1481-6e154cba7bd44c58ad861af04ae31058",
            "input": " Thus , in addition to the previously characterized FAS - binding factor 1 interacting with the inositol / choline - responsive - element motif , a second motif common to the promoter regions of both FAS genes could be identified .",
            "output": [
                "FAS genes"
            ]
        },
        {
            "id": "task1481-a5d3cab862dd44b88497b07692b351a6",
            "input": " Administration of SnCl2 and ZnSO4 ( group V ) resulted in a decrease of ALA - D activity and in an increase in CP - U .",
            "output": [
                "ALA - D"
            ]
        },
        {
            "id": "task1481-14df809881e24916bfb55d2836744343",
            "input": " Purified phosphorylated PhoP ( PhoPP ) had a half - life of approximately 2 . 5 h , which was reduced to about 15 min by addition of the same molar amount of * PhoR ( the cytoplasmic region of PhoR ) .",
            "output": [
                "* PhoR"
            ]
        },
        {
            "id": "task1481-0adb0e73c1214d7aa0967dbf7bfe4bad",
            "input": " In the case of the pT181 plasmid , inactivation of the initiator RepC protein occurs by the attachment of an oligonucleotide to its active tyrosine residue .",
            "output": [
                "initiator RepC protein"
            ]
        },
        {
            "id": "task1481-f245c1441a8240478bb85f5e9dff691c",
            "input": " These results suggest that camptothecin resistance in CEM / DOX cells is due to different mechanism ( s ) than topoisomerase - or P - glycoprotein - associated multidrug resistance .",
            "output": [
                "P - glycoprotein"
            ]
        },
        {
            "id": "task1481-f64b013ffce8420691c043a46fdc0f5a",
            "input": " In this report , we describe a patient with renal cell carcinoma who experienced ventricular tachycardia while undergoing treatment with high - dose bolus IL - 2 .",
            "output": [
                "IL - 2"
            ]
        },
        {
            "id": "task1481-c114202a18aa457fb0db30f271d75152",
            "input": " One cytoplasmic target which reflects the functional state of the plastids is protein kinase C .",
            "output": [
                "protein kinase C"
            ]
        },
        {
            "id": "task1481-9724937aba9c48ad8d3946fbc0bd898d",
            "input": " The protein kinase C inhibitor GF - 109203X abolished the activation by phorbol ester and inhibited the effect of CCK by 78 % but had no effect on EGF - activated MAPK activity .",
            "output": [
                "protein kinase C"
            ]
        },
        {
            "id": "task1481-796deea9f6554ae68d8065e29b64ed33",
            "input": " In addition , both inhibitors blocked phosphatidylcholine hydrolysis and protein kinase C translocation .",
            "output": [
                "protein kinase C"
            ]
        },
        {
            "id": "task1481-2e79ca29581849d08e4e647d403e0ad6",
            "input": " The liver - specific sequence contains unique consensus sites for phosphorylation by cyclic AMP - dependent protein kinase and by protein kinase C .",
            "output": [
                "protein kinase C"
            ]
        },
        {
            "id": "task1481-5f55bbfe6e20427bafe5a2cdeb991ba8",
            "input": " In contrast to the restricted tissue expression of gonadotropin and TSH receptors in gonads and thyroid , respectively , LGR4 is expressed in diverse tissues including ovary , testis , adrenal , placenta , thymus , spinal cord , and thyroid , whereas LGR5 is found in muscle , placenta , spinal cord , and brain .",
            "output": [
                "TSH receptors"
            ]
        },
        {
            "id": "task1481-4346cd570754496f83e17bc88c016284",
            "input": " Extracellular regulated kinases ( ERK ) 1 and ERK2 are authentic substrates for the dual - specificity protein - tyrosine phosphatase VHR .",
            "output": [
                "tyrosine phosphatase"
            ]
        },
        {
            "id": "task1481-cdf7a882e2194a748729c4844e47c5d3",
            "input": " Blood pressure was controlled long term ( with / without diuretics / beta - adrenoreceptor blocking drugs ) in sixteen out of nineteen patients with mild - moderate hypertension .",
            "output": [
                "beta - adrenoreceptor"
            ]
        },
        {
            "id": "task1481-a36f1d9dc4bf4eb194fb6e75b007056a",
            "input": " Mutations of the human PTEN gene .",
            "output": [
                "human PTEN gene"
            ]
        },
        {
            "id": "task1481-34b3c8e79306415fb34d3de0d30fb7e5",
            "input": " This enhancer element functioned in a position - and orientation - independent manner both on the Pax - QNR P0 promoter and the heterologous thymidine kinase promoter .",
            "output": [
                "thymidine kinase"
            ]
        },
        {
            "id": "task1481-9275e2af8a7c4bcea7708ca760d8c66b",
            "input": " In further support of the biological significance of these DNA - protein interactions , the IL2RA oligonucleotide from - 291 to - 245 proved to be sufficient in either orientation to confer PMA inducibility to the mitogen - insensitive thymidine kinase gene promoter in Jurkat cells .",
            "output": [
                "thymidine kinase"
            ]
        },
        {
            "id": "task1481-2482be0915b643618c2fc717dfa99ba3",
            "input": " When linked to the herpes simplex thymidine kinase minimal promoter , this fragment acts as an enhancing element in Rcho but not GC cells .",
            "output": [
                "thymidine kinase"
            ]
        },
        {
            "id": "task1481-2d5cbdb779dc4f20938564e4dd4777e3",
            "input": " We have determined the molecular organization and transcription start points ( tsp ) for the murine gene ( TK ) encoding thymidine kinase .",
            "output": [
                "thymidine kinase"
            ]
        },
        {
            "id": "task1481-b89c918608fc4449bc0bcc098c2e89c6",
            "input": " The mouse alpha A - CRYBP1 gene specifies a 2 , 688 - amino acid protein with 72 % amino acid identity to its human homologue , PRDII - BF1 .",
            "output": [
                "PRDII - BF1"
            ]
        },
        {
            "id": "task1481-81b3f271fb774b3290195a9510843c29",
            "input": " Paradoxically there is a decrease in the level of soluble A beta secreted from the cells .",
            "output": [
                "soluble A beta"
            ]
        },
        {
            "id": "task1481-35113ed9a6b34cdbbac7eed27cb7d6f1",
            "input": " The fz - 1 and fz - 2 genes are widely expressed in rat tissues with the highest steady - state levels of mRNA in kidney , liver , heart , uterus , and ovary .",
            "output": [
                "fz - 1"
            ]
        },
        {
            "id": "task1481-2c3d611a6d5f442786f78610477ed9d9",
            "input": " fz - 1 and - 2 mRNA levels were greater in neonatal than in corresponding adult tissues .",
            "output": [
                "fz - 1"
            ]
        },
        {
            "id": "task1481-dbb08b8c31014c549804db4b1aee3281",
            "input": " The contribution of residues outside the Ras binding domain of Raf ( RafRBD ) to Ras - Raf interaction and Ras - dependent Raf activation has remained unresolved .",
            "output": [
                "Ras binding domain"
            ]
        },
        {
            "id": "task1481-316db4dbdf79453e9b591930e5544919",
            "input": " The D . discoideum proteins were entirely conserved over the four regions known to be important for GTP binding and all contained the C - terminal CAAX aa motifs shared by other Rho proteins .",
            "output": [
                "Rho proteins"
            ]
        },
        {
            "id": "task1481-7a7e4fd1ffd147f4ba93a767741875ec",
            "input": " Thus , transgene expression directed by both the human and mouse Rb promoters is restricted to a subset of tissues in which Rb is normally expressed during embryogenesis .",
            "output": [
                "mouse Rb promoters"
            ]
        },
        {
            "id": "task1481-d6b1ebbc97974146be9082b8a8b1010f",
            "input": " We propose that optimal transcription of the gD gene depends on the interaction of ICP4 with multiple binding sites across the gene and cellular factors that recognize specific sequence elements in the promoter .",
            "output": [
                "gD gene"
            ]
        },
        {
            "id": "task1481-d3e70c95edf64199b8fd34cf08f719ad",
            "input": " The occurrence of the different types of TCRB rearrangement patterns has implications for PCR - based clonality assessment and for PCR - based detection of minimal residual disease via TCRB gene analysis .",
            "output": [
                "TCRB gene"
            ]
        },
        {
            "id": "task1481-445b6a966e0542619f22335dc5bec9ea",
            "input": " However the precise function of DNA - PK in DNA double - strand break repair is not known .",
            "output": [
                "DNA - PK"
            ]
        },
        {
            "id": "task1481-55a01b06e21b40f28dc43842c5c507e9",
            "input": " Coimmunoprecipitation analysis suggests that these residues likely contribute to the multimerization function required for homomeric complex formation or heteromeric complex formation with p50 in that no association of p65 delta with itself or with p50 was evident .",
            "output": [
                "p65 delta"
            ]
        },
        {
            "id": "task1481-1ec11edb24ec4ec79cc70bf3c5957c1f",
            "input": " The activated glucocorticoid receptor forms a complex with Stat5 and enhances Stat5 - mediated transcriptional induction .",
            "output": [
                "glucocorticoid receptor"
            ]
        },
        {
            "id": "task1481-8bc3f9c9ef2f4af5873610854c37567b",
            "input": " Twelve patients of leprosy with arthritis and 161 patients without arthritis were studied for immunological parameters like immunoglobulins ( IgG , IgM , IgA ) , C - reactive proteins and rheumatoid factor .",
            "output": [
                "rheumatoid factor"
            ]
        },
        {
            "id": "task1481-48d35c16a1f949088c8c76196178a15a",
            "input": " A new simple identification of rheumatoid factor on nitrocellulose was developed that allows quantitative detection .",
            "output": [
                "rheumatoid factor"
            ]
        },
        {
            "id": "task1481-d3e269524e6449eba709878873822187",
            "input": " Antinuclear antibodies , rheumatoid factor and C - reactive protein in serum of normal women using oral contraceptives .",
            "output": [
                "rheumatoid factor"
            ]
        },
        {
            "id": "task1481-73a7186a9769442a8b529572294aa6d2",
            "input": " The effective use of superoxide dismutase from human erythrocytes in the late stages of experimental influenza infection",
            "output": [
                "superoxide dismutase"
            ]
        },
        {
            "id": "task1481-033a80029f744549a82e9895e81df477",
            "input": " A surge in the rate of ascorbyl radical production , directly correlated with oxyradical stress and an abrupt fall in superoxide dismutase activity in the granuloma , indicates ' switching on ' of a free radical - dependent machinery for the formation of granuloma after vasectomy .",
            "output": [
                "superoxide dismutase"
            ]
        },
        {
            "id": "task1481-a100d4a483f445439fbdb1579bae8613",
            "input": " We report five of 13 evaluable patients undergoing allogeneic sibling BM or PBSC transplantation for MM between 1990 and 1997 who met the criteria for adjuvant alpha - IFN therapy .",
            "output": [
                "alpha - IFN"
            ]
        },
        {
            "id": "task1481-5e1d08db6a724d8f81a4afa2482e4be0",
            "input": " The use of specific somatic cell hybrids have allowed us to locate the YAC contig telomeric to the D3F15S2 locus , in a region which is frequently deleted in lung carcinomas .",
            "output": [
                "D3F15S2 locus"
            ]
        },
        {
            "id": "task1481-add1e70255d444109cb953f00a88dfb9",
            "input": " Elevated systolic blood pressure and high postglucose serum insulin levels showed an independent , significant association with left ventricular mass in female diabetic subjects .",
            "output": [
                "serum insulin"
            ]
        },
        {
            "id": "task1481-f52b2ca833db417d814ab19536818917",
            "input": " The p58 ( PITSLRE beta 1 ) protein kinase ( PK ) is a member of a large supergene family related to the master mitotic protein kinase , p34cdc2 .",
            "output": [
                "PITSLRE beta 1"
            ]
        },
        {
            "id": "task1481-15a1399290f242549471106be7f2714d",
            "input": " Similarly , beta adrenoceptors blockade has been shown to be of value in achieving continence in a small group of patients .",
            "output": [
                "beta adrenoceptors"
            ]
        },
        {
            "id": "task1481-cd9ee7be6b7b48319373e26ff628a1dc",
            "input": " Prolongation of prothrombin time was not due to depletion of vitamin K - dependent coagulation factors or manifest fibrinolysis , but due to the presence of circulating fibrinogen fibrinmonomer - FDP complexes .",
            "output": [
                "fibrinogen fibrinmonomer"
            ]
        },
        {
            "id": "task1481-e176636882244d4ba96db66c64d8552b",
            "input": " Whereas mutant 6C4 specified a wild - type - size Pol protein , we detected no full - length Pol protein in 7E4 - infected cell extracts .",
            "output": [
                "mutant 6C4"
            ]
        },
        {
            "id": "task1481-ca0381da7787462597d73c985f5db3c2",
            "input": " 7 - Nitroindazole ( 7NI ) , a relatively selective neuronal nitric oxide synthase ( nNOS ) inhibitor . was intraperitoneally administered to the guinea pigs 30 minutes before the onset of local anoxia .",
            "output": [
                "nitric oxide synthase"
            ]
        },
        {
            "id": "task1481-60c0cc60437d46bda7d271f918393f9e",
            "input": " These include not only antioxidants , N - methyl - D - aspartate receptor antagonists , inhibitors of glutamate release , calcium channel blockers , polyamine antagonists , and nitric oxide synthase inhibitors , but cannabinoids , aspirin , melatonin , and vitamin B - 12 .",
            "output": [
                "nitric oxide synthase"
            ]
        },
        {
            "id": "task1481-3033d928029d40f29aca0adad3538caf",
            "input": " Human plastin genes .",
            "output": [
                "Human plastin genes"
            ]
        },
        {
            "id": "task1481-922771ca4477460ca20b4518b6a6e066",
            "input": " These data suggest that the secreted , truncated receptor encoded by the 2 . 6 - kb c - erbB transcript can bind to TGF alpha and may play an important growth - regulatory function in vitro .",
            "output": [
                "TGF alpha"
            ]
        },
        {
            "id": "task1481-100c2566459642ee82e076079fb38983",
            "input": " Human parvovirus B19 gene expression from the viral p6 promoter ( B19p6 ) is restricted to primary human hematopoietic cells undergoing erythroid differentiation .",
            "output": [
                "viral p6 promoter"
            ]
        },
        {
            "id": "task1481-ca807fb2ac62402fa956b3b31e72f0f6",
            "input": " The consensus mammalian ER stress response element ( ERSE ) conserved among grp promoters consists of a tripartite structure CCAAT ( N9 ) CCACG , with N being a strikingly GC - rich region of 9 bp .",
            "output": [
                "grp promoters"
            ]
        },
        {
            "id": "task1481-24fa68b1c21f46a3807a15f604880ed6",
            "input": " ( We observed a ferritin value as high as 47 mg / L in one patient . ) Results with all these kits did not inter - compare well for ferritin concentrations greater than 300 micrograms / L , a finding that casts further doubt on the controversial use of serum ferritin measurement in cases of iron overload .",
            "output": [
                "serum ferritin"
            ]
        },
        {
            "id": "task1481-4501d05dc14e422695963503f1a9cde8",
            "input": " Relation between circulating immune complexes and serum ferritin in hemosiderosis of different etiologies",
            "output": [
                "serum ferritin"
            ]
        },
        {
            "id": "task1481-f67df75fafee4142ba320888d6dec185",
            "input": " A higher percentage of children with cerebral malaria ( 40 per cent ) than with non - cerebral malaria ( 29 per cent ) or controls ( 20 per cent ) also had either serum ferritin < 100 micrograms / l and inflammation or sTfR > 7 . 3 mg / l or both .",
            "output": [
                "serum ferritin"
            ]
        },
        {
            "id": "task1481-1d550580fd164e62a7de066459134918",
            "input": " Pancreatic expression of the glucagon gene depends on multiple transcription factors interacting with at least three DNA control elements : G1 , the upstream promoter element , and G2 and G3 , two enhancer - like sequences .",
            "output": [
                "glucagon gene"
            ]
        },
        {
            "id": "task1481-c98a613e2b2741ca8d7febfbfc8c16af",
            "input": " Nucleotide sequence of the gag gene and gag - pol junction of feline leukemia virus .",
            "output": [
                "gag gene"
            ]
        },
        {
            "id": "task1481-f2fb4b8914a34ec98f2a294f5ef3b708",
            "input": " The yjr041c delta haploid cells gave rise to microcolonies comprising about 20 to 50 cells .",
            "output": [
                "yjr041c delta"
            ]
        },
        {
            "id": "task1481-aebe0fc0182c4eb9851f69ecd794824d",
            "input": " Consistent with this observation , introduction of Smad sites into a TGFbeta - insensitive LEF1 / TCF target gene confers cooperative TGFbeta and Wnt responsiveness to the promoter .",
            "output": [
                "Smad sites"
            ]
        },
        {
            "id": "task1481-2bcc7756db7f4ac599ff6c275395bbc7",
            "input": " An additional stimulation of D1 receptors by giving SKF38393 30 min later produced an almost continuous pattern of jaw openings but less closure movements from the rest position , and the openings were accompanied by frequent tongue protrusions .",
            "output": [
                "D1 receptors"
            ]
        },
        {
            "id": "task1481-03d1dc813f0048ba90c14dd31459d4af",
            "input": " Effects of long - term use of raloxifene , a selective estrogen receptor modulator , on thyroid function test profiles .",
            "output": [
                "estrogen receptor"
            ]
        },
        {
            "id": "task1481-e7de9e3979f9477fa1f35ed7522bf1c0",
            "input": " The nucleotide sequence of the estrogen receptor gene of Oreochromis aureus ( OaER ) indicates that the hormone - binding E domain is composed of 4 exons interspersed by short introns of only 0 . 18 - 1 . 3 kb each .",
            "output": [
                "estrogen receptor"
            ]
        },
        {
            "id": "task1481-6777f1d9665e4ae38fd3343314f8fdd2",
            "input": " A selective transcriptional induction system for mammalian cells based on Gal4 - estrogen receptor fusion proteins .",
            "output": [
                "estrogen receptor"
            ]
        },
        {
            "id": "task1481-f6f7167f7f2c4f95963e9a936524b93d",
            "input": " Heterodimerization mutant RXR failed to alter GFP - VDR and nlsGFP - VDR distribution or activity .",
            "output": [
                "Heterodimerization mutant RXR"
            ]
        },
        {
            "id": "task1481-cbbc20195ad84871ab21bdabdc466135",
            "input": " The pattern of expression of this and other Chi26 / Chi33 chimeric promoters suggest that the E - region contains cis - acting sequences which activate transcription in aleurone and silence transcription in leaves .",
            "output": [
                "E - region"
            ]
        },
        {
            "id": "task1481-cd3c2b5f8b784ab9aab5277f4453394e",
            "input": " Characterization and targeted disruption of murine Nup50 , a p27 ( Kip1 ) - interacting component of the nuclear pore complex .",
            "output": [
                "murine Nup50"
            ]
        },
        {
            "id": "task1481-8f8eaa3be7474d2fac509138931dedeb",
            "input": " The effects of dopamine and of dopamine D2 receptor blocker haloperidol on the activity of carotid chemoreceptors were studied in 24 anesthetized , paralyzed and artificially ventilated newborn kittens aged 0 - 17 days .",
            "output": [
                "dopamine D2 receptor"
            ]
        },
        {
            "id": "task1481-3e92f88231924f0088cdcb657a90a383",
            "input": " Protein sequencing , electrophoretic mobility shift assay , and immunoblot analyses identify p54 and p47 / 48 as members of the hepatocyte nuclear factor 3 ( HNF3 [ forkhead ] ) family of transcription factors .",
            "output": [
                "p47 / 48"
            ]
        },
        {
            "id": "task1481-17007b6d9f63482ca49269b66f3abe5c",
            "input": " Reversal of ' refractory septic shock ' by infusion of amrinone and angiotensin II in an anthracycline - treated patient .",
            "output": [
                "angiotensin II"
            ]
        },
        {
            "id": "task1481-5156d34f5bf043d4afaa550238d8ee1d",
            "input": " Titres of antistreptolysin O in mothers of children affected with Down ' s syndrome .",
            "output": [
                "antistreptolysin O"
            ]
        },
        {
            "id": "task1481-5654a476594549ff8cee766522984778",
            "input": " Blood coagulation Factor X and its activated form Factor Xa play an essential role in the midphase of the clotting cascade .",
            "output": [
                "Factor Xa"
            ]
        },
        {
            "id": "task1481-da7d097dfe824bfa855be8548ad79994",
            "input": " In four calves given Haemonchus contortus larvae , the serum pepsinogen concentration rose quickly to reach a mean of 3 . 5 iu tyrosine on day 14 after infection .",
            "output": [
                "serum pepsinogen"
            ]
        },
        {
            "id": "task1481-ad0f57adc2cb48a790fe3ec6dafefb1e",
            "input": " As to the side effects of SISO , cylindruria with aggravation of microscopic hematuria and elevations of GOT , GPT and A1 - P were observed each one of them , respectively .",
            "output": [
                "A1 - P"
            ]
        },
        {
            "id": "task1481-fa685a98a5354dedbf48e3b947fa8b2d",
            "input": " No transactivation of the ovalbumin promoter ( pLovTATA ) template control was observed .",
            "output": [
                "ovalbumin promoter"
            ]
        },
        {
            "id": "task1481-4230950b39f64cff8e4e14e4fd8cf08c",
            "input": " The three OAS genes are flanked by markers WI - 10614 ( cen ) and D12S2293 ( tel ) and are contained within three sets of overlapping cosmid clones .",
            "output": [
                "OAS genes"
            ]
        },
        {
            "id": "task1481-610651f4599c4e8e8dda63aec98ce69e",
            "input": " Amniotic fluid ionic concentration in response to chronic fetal vasopressin infusion .",
            "output": [
                "fetal vasopressin"
            ]
        },
        {
            "id": "task1481-5e03b80afedd4326a22a4a112be0a5b3",
            "input": " Acanthamoeba myosin I heavy chain kinase ( MIHCK ) phosphorylates the heavy chains of amoeba myosins I , increasing their actin - activated ATPase activities .",
            "output": [
                "amoeba myosins I"
            ]
        },
        {
            "id": "task1481-2b51e02d652f44178c4f1581d61a4a0b",
            "input": " Parathyroid hormone responses of cyclic AMP - , serum - and phorbol ester - responsive reporter genes in osteoblast - like UMR - 106 cells .",
            "output": [
                "Parathyroid hormone"
            ]
        },
        {
            "id": "task1481-d51c9d4f86ba487896627a0950c499b2",
            "input": " LCCH1 was identical to the Rdl gene , a known GABA receptor subunit gene from D . melanogaster , whereas LCCH2 and LCCH3 were novel D . melanogaster sequences that exhibited structural similarity to other members of the ligand - gated chloride channel gene family .",
            "output": [
                "Rdl gene"
            ]
        },
        {
            "id": "task1481-54fc709bbfa9452eb38fd830801f6306",
            "input": " Consistent with this hypothesis , stimulation of A ( 2A ) - R or PKA enhanced nuclear aPKC activity .",
            "output": [
                "nuclear aPKC"
            ]
        },
        {
            "id": "task1481-eaf1b90f0b9e41d4be677ce3460ea746",
            "input": " To gain additional insights into this novel apoptotic checkpoint , we have now characterized the mouse survivin locus .",
            "output": [
                "mouse survivin locus"
            ]
        },
        {
            "id": "task1481-c2508374bd754617b043b4164dcdfafb",
            "input": " It was previously shown that Vi antigen expression was regulated by a system similar to the rcs regulatory system involved in colanic acid synthesis in Escherichia coli .",
            "output": [
                "Vi antigen"
            ]
        },
        {
            "id": "task1481-48685b9d0213464eb01ae728e3b284ba",
            "input": " Various stimuli inactivate IkappaB alpha by triggering phosphorylation of the N - terminal residues Ser32 and Ser36 .",
            "output": [
                "IkappaB alpha"
            ]
        },
        {
            "id": "task1481-a5c5665918b6490599b4f8814799b752",
            "input": " The highly conserved region of U6 snRNA has a structural similarity with the catalytic domain of the negative strand of the satellite RNA of tobacco ring spot virus [ ( - ) sTRSV ] , suggesting that the highly conserved region of U6 snRNA forms the catalytic center .",
            "output": [
                "U6 snRNA"
            ]
        },
        {
            "id": "task1481-15695b918aec4943bb313b5dca9645eb",
            "input": " The prgX gene is adjacent to prgQ which provides the promoter for prgB expression .",
            "output": [
                "prgX gene"
            ]
        },
        {
            "id": "task1481-c705a0ff70204b7bacc0336da48866b1",
            "input": " We have previously shown that UNC - 4 expression in the VA motor neurons specifies the wild - type pattern of presynaptic input .",
            "output": [
                "UNC - 4"
            ]
        },
        {
            "id": "task1481-f37d40861ff0440483b210deea44b5b8",
            "input": " psrA mutants of both Pseudomonas species lost the ability to induce rpoS expression at stationary phase , but they retained the ability to produce quorum - sensing autoinducer molecules .",
            "output": [
                "psrA mutants"
            ]
        },
        {
            "id": "task1481-06062bfae6a84b5aa6bffe370d3938fa",
            "input": " Unconventional mRNA processing in the expression of two calcineurin B isoforms in Dictyostelium .",
            "output": [
                "calcineurin B isoforms"
            ]
        },
        {
            "id": "task1481-d8766d059e9143f3bd50f41ca5b91a04",
            "input": " Searching the human DNA data base of expressed sequence tags ( EST ) revealed novel partial sequences similar to , but distinct from , the sequences of the previously known PEF proteins .",
            "output": [
                "PEF proteins"
            ]
        },
        {
            "id": "task1481-cba279f6d3bd4a5487687bddfc875235",
            "input": " Using beta 1 - AR - luciferase reporter recombinants , we have previously determined that important beta 1 - AR genetic elements controlling expression within the C6 glioma cell line are contained within the region - 396 to - 299 , relative to the translational start site .",
            "output": [
                "luciferase reporter"
            ]
        },
        {
            "id": "task1481-5a13920911664f3ea255d4c6e1c51570",
            "input": " Concerning the practical approach in a clinical setting , it has to be pointed out that with these diseases a hepatitis C infection has to be considered and testing for hepatitis C antibodies and , if positive , hepatitis C - RNA is indicated .",
            "output": [
                "hepatitis C antibodies"
            ]
        },
        {
            "id": "task1481-361415cbaf2744f18ea0a4870fa9b926",
            "input": " Promoter elements and transcriptional control of the mouse acetylcholinesterase gene .",
            "output": [
                "mouse acetylcholinesterase gene"
            ]
        },
        {
            "id": "task1481-1d7151f8113c43d289038c450149713f",
            "input": " Activation of the cytotactin promoter by the homeobox - containing gene Evx - 1 .",
            "output": [
                "cytotactin promoter"
            ]
        },
        {
            "id": "task1481-a2ea071b79f14878aa12bfb774b1ca92",
            "input": " Interestingly , basal MAPK , but not Raf - 1 , activity was constitutively enhanced in Jak1 - deficient HeLa cells .",
            "output": [
                "Raf - 1"
            ]
        },
        {
            "id": "task1481-614e5a8d6bca4783bac6fe8b951813b5",
            "input": " An in vitro Raf - 1 kinase assay , however , failed to detect LPS - induced Raf - 1 kinase activity in RAW 264 . 7 cells , suggesting that in RAW 264 . 7 cells , Raf - 1 kinase is not an activating component of the LPS signaling pathway regulating MAPK activity or sIL - 1Ra promoter activity .",
            "output": [
                "Raf - 1"
            ]
        },
        {
            "id": "task1481-ac34c19236294103a35036f9df396e8c",
            "input": " Inhibition of Raf - 1 signaling by a monoclonal antibody , which interferes with Raf - 1 activation and with Mek substrate binding .",
            "output": [
                "Raf - 1"
            ]
        },
        {
            "id": "task1481-65e033f3d27e4f7aa2f18be329c33c89",
            "input": " Co - operativity of functional domains in the muscle - specific transcription factor Myf - 5 .",
            "output": [
                "Myf - 5"
            ]
        },
        {
            "id": "task1481-6264f9c003ed4c65acce3ac4615384d3",
            "input": " We identified two potential phosphorylation sites at serine49 and serine133 , both of which seem to be necessary for Myf - 5 activity .",
            "output": [
                "Myf - 5"
            ]
        },
        {
            "id": "task1481-c24833e58cad4d498e2356d59be9a957",
            "input": " To elucidate the molecular mechanism by which the Ras signaling pathway activates a cell - type - specific gene , we have used the pituitary - specific rat prolactin ( rPRL ) promoter as a target of oncogenic Ras and Raf in GH4 rat pituitary cells .",
            "output": [
                "oncogenic Ras"
            ]
        },
        {
            "id": "task1481-31541deda4344651a396ff7c4b2ef232",
            "input": " Furthermore , we have identified the major open reading frame ( RF4 ; 2 . 3 kb ) as being essential for activation , and we have shown that the NF kappa B , SP1 , and TATA box motifs in the human immunodeficiency virus LTR are all required for full induction of the promoter by the HHV - 6 - encoded transactivator .",
            "output": [
                "NF kappa B"
            ]
        },
        {
            "id": "task1481-a4c7bc07399a4db7b4ebe6ad8b69d135",
            "input": " We therefore investigated whether the promoter activity of the mouse TRH gene is directly regulated by RA using a transient transfection assay into CV - 1 cells .",
            "output": [
                "mouse TRH gene"
            ]
        },
        {
            "id": "task1481-d929b43a10fe4a7cad997560424d836c",
            "input": " Taken together , these results indicate that ICSBP and PU . 1 are critical elements for IL - 18 gene expression .",
            "output": [
                "PU . 1"
            ]
        },
        {
            "id": "task1481-fc58e2eb495c44598abc47c66b26bb38",
            "input": " The findings in the human multiple myeloma cell lines represent the first examples of B cells with downregulated PU . 1 expression and apparently contradict observations in the murine system in which PU . 1 is expressed and active in plasmacytoma cell lines .",
            "output": [
                "PU . 1"
            ]
        },
        {
            "id": "task1481-831869bd95ac41d5816628dd054d7677",
            "input": " YDL003w ( also termed MCD1 ) is a homologue of Schizosaccharomyces pombe rad21 , an essential gene implicated in DNA double - strand break repair and nuclear organization in fission yeast .",
            "output": [
                "Schizosaccharomyces pombe rad21"
            ]
        },
        {
            "id": "task1481-de412a9eb26a4526816d5493e8d77a9e",
            "input": " Using gel retardation analysis , four binding sites for Rap1p have been identified within the promoter of the RAP1 gene .",
            "output": [
                "RAP1 gene"
            ]
        },
        {
            "id": "task1481-799e96e0b15f441f910605d3ffcf0f7f",
            "input": " The present report shows that a cis - acting element between - 189 and - 175 bp , which binds thyroid transcription factor - 1 ( TTF - 1 ) , is involved in both activities .",
            "output": [
                "TTF - 1"
            ]
        },
        {
            "id": "task1481-e25d9f6a38144e4d9f71739c563ca532",
            "input": " Negative modulation of alpha1 ( I ) procollagen gene expression in human skin fibroblasts : transcriptional inhibition by interferon - gamma .",
            "output": [
                "interferon - gamma"
            ]
        },
        {
            "id": "task1481-bffcf4d7d17a419d973dc85cf51a78de",
            "input": " Soggy , a spermatocyte - specific gene , lies 3 . 8 kb upstream of and antipodal to TEAD - 2 , a transcription factor expressed at the beginning of mouse development .",
            "output": [
                "TEAD - 2"
            ]
        },
        {
            "id": "task1481-223f638d4855428fb9a574021d1bea2e",
            "input": " Spen is the only known homeotic protein with RNP binding motifs , which indicates that splicing , transport , or other RNA regulatory steps are involved in the diversification of segmental morphology .",
            "output": [
                "homeotic protein"
            ]
        },
        {
            "id": "task1481-b8fcbebc0a8c4622b2893e9186b29795",
            "input": " These results suggest that the Reg1 - Glc7 phosphatase is a cytoplasmic component of the machinery responsible for returning Snf1 kinase activity to its basal level and reestablishing glucose repression .",
            "output": [
                "Snf1 kinase"
            ]
        },
        {
            "id": "task1481-c44c98c3f9b648abba33e782dffd527c",
            "input": " Recently we have performed a detailed analysis of specific neuronal populations affected by the mutation which shed new light on the role of Krox - 20 in the segmentation and on the physiological consequences of its inactivation .",
            "output": [
                "Krox - 20"
            ]
        },
        {
            "id": "task1481-0637ec4d781f4e08a7122e705d8869b9",
            "input": " We have thus cloned two yeast homologs of mammalian p220 .",
            "output": [
                "mammalian p220"
            ]
        },
        {
            "id": "task1481-7be7d5e18cfb42098b9427dcc5a14448",
            "input": " From a chromosomal cosmid library of Streptomyces argillaceus , a Mtm producer , a clone ( cosAR7 ) was isolated by homology to the actI / III region of S . coelicolor and the strDEM genes of S . griseus .",
            "output": [
                "strDEM genes"
            ]
        },
        {
            "id": "task1481-3241df33adec4157ab854a4f972b7f91",
            "input": " Fluorescence in situ hybridization was used to investigate the physical distribution and revealed that both retrotransposon families are present on all sugar beet chromosomes and largely excluded from chromosomal regions harbouring the 18S - 5 . 8S - 25S rRNA genes .",
            "output": [
                "5 . 8S"
            ]
        },
        {
            "id": "task1481-3279fc1a98f64fb78d55faaab7208736",
            "input": " Amplification of 4q21 - q22 and the MXR gene in independently derived mitoxantrone - resistant cell lines .",
            "output": [
                "MXR gene"
            ]
        },
        {
            "id": "task1481-9501e882c89246c1b2f355523650b559",
            "input": " Interestingly , VDR was able to bind to VDREs with high affinity and to fully activate transcription in intact yeast cells in the presence of the retinoid X receptor ( RXR ) .",
            "output": [
                "retinoid X receptor"
            ]
        },
        {
            "id": "task1481-9aadabaae6534a22a5d08548b379091d",
            "input": " Transient transfection assays indicated that the ( - 4551 ) UCP1 - CAT construct , containing the 5 ' - regulatory region of the rat ucp - 1 gene , was activated by PPARalpha co - transfection in a dose - dependent manner and this activation was potentiated by Wy 14 , 643 and retinoid X receptor alpha .",
            "output": [
                "retinoid X receptor"
            ]
        },
        {
            "id": "task1481-301b6584e6d54f69a115e90cccae14c4",
            "input": " Sequence and deletion analysis of the recombination enhancement gene ( ref ) of bacteriophage P1 : evidence for promoter - operator and attenuator - antiterminator control .",
            "output": [
                "recombination enhancement gene"
            ]
        },
        {
            "id": "task1481-400cf75032d7416389694839b8d56e14",
            "input": " The hematopoietic form of PTPN6 transcript is initiated at a downstream promoter separated by 7 kb from the first .",
            "output": [
                "PTPN6 transcript"
            ]
        },
        {
            "id": "task1481-09c358e5f7714d429b6a80b2c37d4c63",
            "input": " To examine the effect of the cAMP signal transduction pathway on transcription of the gene encoding the catalytic subunit of glucose - 6 - phosphatase ( G6Pase ) , G6Pase - chloramphenicol acetyltransferase ( CAT ) fusion genes were transiently transfected into either the liver - derived HepG2 or kidney - derived LLC - PK cell line .",
            "output": [
                "chloramphenicol acetyltransferase"
            ]
        },
        {
            "id": "task1481-5ac0c7db08024623b8d1c7c22e5ceadd",
            "input": " This transformation suppression by Rb was further shown to be due to transcriptional repression of neu using Rb expressing effector plasmid and neu promoter - chloramphenicol acetyltransferase reporter gene .",
            "output": [
                "chloramphenicol acetyltransferase"
            ]
        },
        {
            "id": "task1481-65ca9d0e3f25404cb78973cbcf458252",
            "input": " We have used the chloramphenicol acetyltransferase ( CAT ) reporter gene system to study the effect of T on the long terminal repeats ( LTRs ) of a large family of human endogenous retrovirus - like sequences , RTVL - H .",
            "output": [
                "chloramphenicol acetyltransferase"
            ]
        },
        {
            "id": "task1481-7b44f5514b2f4ef38b10f597a6ad8ebc",
            "input": " Two plasmids , one containing the amino terminus of P fused to the DNA - binding domain of the yeast transactivator , GAL4 , and the other containing the amino terminus of NP fused to the herpesvirus transactivator , VP16 , were transfected in COS - 1 cells along with a chloramphenicol acetyltransferase ( CAT ) reporter plasmid containing GAL4 DNA - binding sites .",
            "output": [
                "chloramphenicol acetyltransferase"
            ]
        },
        {
            "id": "task1481-9bf0f4bf61e74ec49e664f65a110e4ad",
            "input": " This novel TRPC7 gene could be a candidate gene for genetic disorders such as bipolar affective disorder , nonsyndromic hereditary deafness , Knobloch syndrome , and holoprosencephaly , which were mapped to this region .",
            "output": [
                "TRPC7 gene"
            ]
        },
        {
            "id": "task1481-2611ce2776df40f987debc3708cb596e",
            "input": " The major promoter element of the Xenopus laevis 5S RNA gene is located within the transcribed region of the gene and forms the binding site for the transcription initiation factor TFIIIA .",
            "output": [
                "5S RNA"
            ]
        },
        {
            "id": "task1481-7151a42bc7664cab98f9a2335e47e435",
            "input": " Antibodies against REAP - 1 inhibit in vitro RNA editing reactions confirming its role in RNA editing .",
            "output": [
                "REAP - 1"
            ]
        },
        {
            "id": "task1481-c3a2cdcc2f6b481e856d2829e7c1aa78",
            "input": " Plasma beta - thromboglobulin ( beta - TG ) , a platelet - specific protein , is a marker of intravascular platelet degranulation .",
            "output": [
                "beta - TG"
            ]
        },
        {
            "id": "task1481-ef2c41a318384479aca9d847553bd8b8",
            "input": " The Sty1 kinase is stimulated by a variety of different stress conditions including osmotic and oxidative stress and heat shock .",
            "output": [
                "Sty1 kinase"
            ]
        },
        {
            "id": "task1481-9174f75da42d4557b6449410d837ac25",
            "input": " Analysis of WT1 target gene expression in stably transfected cell lines .",
            "output": [
                "WT1 target gene"
            ]
        },
        {
            "id": "task1481-e63ff699117d4f4ca05773dc37862ae2",
            "input": " The exon sequences determined from genomic DNA sequencing showed some differences when compared to the published rat GLUT2 cDNA .",
            "output": [
                "rat GLUT2 cDNA"
            ]
        },
        {
            "id": "task1481-75393468457841818547e733ecf8dd71",
            "input": " Two adjacent , highly homologous endoglucanase genes , celD and celE from Fibrobacter succinogenes S85 , which were separated by an AT - rich 223 - nucleotide intergenic region were characterized .",
            "output": [
                "homologous endoglucanase genes"
            ]
        },
        {
            "id": "task1481-3e8e115c922d448db498502fee53599b",
            "input": " This raises the possibility that recombination occurred between corresponding LTR and vif loci of the quasi - species present in the isolates described here .",
            "output": [
                "vif loci"
            ]
        },
        {
            "id": "task1481-3884635ffc234416bb8c6c77d9bddc4f",
            "input": " Several 35 - mm slides of dystrophin - , laminin - , and concanavalin A ( ConA ) - stained muscle sections were used to calculate myofiber cross - sectional areas and to compare different techniques and settings of an image capture system .",
            "output": [
                "concanavalin A"
            ]
        },
        {
            "id": "task1481-b887a83c3be048efbc1cdf46a22dba26",
            "input": " Defective concanavalin A - induced suppression in bancroftian filariasis .",
            "output": [
                "concanavalin A"
            ]
        },
        {
            "id": "task1481-e375a1d6a9dc4d89a586cb2297d34658",
            "input": " The expected products of the cloned bph genes , except bphA3 , were observed in E . coli in an in vitro transcription - translation system .",
            "output": [
                "bph genes"
            ]
        },
        {
            "id": "task1481-0a9d697ffb4242b19d2635b042335be1",
            "input": " Base substitutions within this NFIL - 6 site resulted in virtual elimination of LPS - induced IL - 1 beta gene transcription .",
            "output": [
                "IL - 1"
            ]
        },
        {
            "id": "task1481-157cff6ce8214453ae247d83d51c6d32",
            "input": " These findings suggest that IL - 1 - stimulated , Rho - dependent cytoskeletal reorganization may cluster signaling molecules in specific architectures that are necessary for persistent cell activation in chronic inflammatory disease .",
            "output": [
                "IL - 1"
            ]
        },
        {
            "id": "task1481-7bc67ff58dc04fe6bd5387fbddf46fbb",
            "input": " Both genes ARO3 and ARO4 are strongly regulated under the general control regulatory system .",
            "output": [
                "genes ARO3"
            ]
        },
        {
            "id": "task1481-a38ba99dbdfe42599d8dca348cfcfb66",
            "input": " VAV and SOCS1 form a protein complex through interactions between the VAV NH ( 2 ) - terminal regulatory region and the SH2 domain of SOCS1 in a phosphotyrosine - independent manner .",
            "output": [
                "SH2 domain"
            ]
        },
        {
            "id": "task1481-536da4d2c1444e62b8bd9a238f3ff824",
            "input": " We were able to demonstrate a significant statistical interaction effect between gender and globulin protein concentration on Vu ( p = 0 . 022 ) .",
            "output": [
                "globulin protein"
            ]
        },
        {
            "id": "task1481-42c7da46512f47859470fad433c2c99a",
            "input": " Adhesion was inhibited by mAbs against the COOH - terminus and central cell binding domains of fibronectin , as well as by the corresponding CS1 and RGD peptides .",
            "output": [
                "RGD peptides"
            ]
        },
        {
            "id": "task1481-c1b63f6eca824deba91f36c7769aa1c0",
            "input": " Some CHOP - C / EBP heterodimers apparently bind to alternative DNA sequence and thereby regulate the transcription of other genes .",
            "output": [
                "C / EBP"
            ]
        },
        {
            "id": "task1481-d16bcdf83a4e406a993cdc859f2b075b",
            "input": " However , C / EBP beta stimulated transcription primarily through the cAMP - responsive element ( CRE ) , which maps between positions - 77 to - 94 , but not at the more 5 ' - binding sites .",
            "output": [
                "C / EBP"
            ]
        },
        {
            "id": "task1481-ca04de1170b14fb99a1027c4161078bd",
            "input": " Western blot analyses reveals that cJun and the C / EBP family member C / EBP - beta are physiologically relevant transcription factors whose expression corresponds with mda - 7 mRNA expression .",
            "output": [
                "C / EBP"
            ]
        },
        {
            "id": "task1481-6ea27ca759fb4ceeb1e096aa7f67d8e5",
            "input": " Coexpression of C / EBP alpha altered the cell specificity .",
            "output": [
                "C / EBP"
            ]
        },
        {
            "id": "task1481-90510445fde24264b8fc0b62ceef8fee",
            "input": " Cross - talk between transcription factors NF - kappa B and C / EBP in the transcriptional regulation of genes .",
            "output": [
                "C / EBP"
            ]
        },
        {
            "id": "task1481-fe5349bac7e94363937fea9212053ab0",
            "input": " Previous data suggested a subtle increase in serum P at the time of hCG injection without LH surge reduces the PR of women having oocyte retrievals for IVF ; this study compared PRs of recipients in a shared oocyte program according to the donors ' pre - hCG P level .",
            "output": [
                "pre - hCG"
            ]
        },
        {
            "id": "task1481-b944948cdf8343ae880269b6547ad945",
            "input": " Finally , we tested whether activation by either of these factors is dependent on components of the SAGA complex .",
            "output": [
                "SAGA complex"
            ]
        },
        {
            "id": "task1481-b73ee33fdc654369b877bb958bc7857d",
            "input": " The other end of this cluster contained the human type I cytokeratin K20 and K12 gene loci .",
            "output": [
                "K12 gene"
            ]
        },
        {
            "id": "task1481-b95ec102c02f4c609ab999ef4c4decff",
            "input": " When cotransfected with the HIV LTR CAT into CV - 1 cells , both the pCD41 and pGD41 clones trans - activated the HIV LTR .",
            "output": [
                "HIV LTR"
            ]
        },
        {
            "id": "task1481-de234c1c425e470e80cf614f5b96d6e9",
            "input": " In the HIV LTR , this region has been demonstrated to have both positive and negative regulatory effects on HIV gene expression .",
            "output": [
                "HIV LTR"
            ]
        },
        {
            "id": "task1481-29d8bec082254d07abd663ac16ac9604",
            "input": " The predicted amino acid sequence of the FlaB2 polypeptide was 92 % identical to that of T . pallidum FlaB2 , with a 76 % identity at the nucleotide level .",
            "output": [
                "FlaB2 polypeptide"
            ]
        },
        {
            "id": "task1481-98c0bc56a3fb454c8e056edf89b7ddec",
            "input": " Secretogranin II ( SgII ) is a secretory polypeptide stored in large dense core vesicles of neuroendocrine and neuronal cells .",
            "output": [
                "Secretogranin II"
            ]
        },
        {
            "id": "task1481-09be4e22920047dbb013ebf51092fd5e",
            "input": " Further , cells cotransfected with a UF promoter - luciferase ( - 1935UF - Luc ) reporter gene and the BTEB expression vector had 2 - fold higher Luc activity than those cotransfected with reporter gene and pcDNA - 3 .",
            "output": [
                "UF promoter"
            ]
        },
        {
            "id": "task1481-05be831f765a4b7890c96dabaee66648",
            "input": " There is little similarity among the sequences upstream from the CAP site of the Spec2 genes except the TATA consensus sequence and a repeating trinucleotide , AAC .",
            "output": [
                "Spec2 genes"
            ]
        },
        {
            "id": "task1481-7b840dc3fdf640fcaecd487d67594533",
            "input": " An 81 - nt tandem duplication of the C - terminal coding region is located adjacent to the termination codon of the CyIIIb gene , a potential relic of a slipped mispairing and replication event .",
            "output": [
                "CyIIIb gene"
            ]
        },
        {
            "id": "task1481-d1430cf1c32347a59dff9d669fe85e9a",
            "input": " By sequencing of exonuclease III deletion clones an open reading frame of 405 nucleotides was found coding for a protein of 135 amino acids with a molecular mass of 15 kDa .",
            "output": [
                "exonuclease III"
            ]
        },
        {
            "id": "task1481-e3ca9f1abe2e447fa09314782e96bd40",
            "input": " Human CR2 has a restricted cellular distribution , being expressed on B lymphocytes , dendritic cells of the spleen , pharyngeal epithelial cells , and at low levels on some T lymphocytes .",
            "output": [
                "Human CR2"
            ]
        },
        {
            "id": "task1481-14a25b197b314df79f7aca01ee44aa3f",
            "input": " In vitro , c - Src phosphorylated FAK Tyr - 925 in a glutathione S - transferase - FAK C - terminal domain fusion protein , whereas FAK did not .",
            "output": [
                "c - Src"
            ]
        },
        {
            "id": "task1481-27d01899cdde40e6ac9296a81473bf95",
            "input": " In cotransfection assays , a small fragment of Sin retaining the Src - SH3 - binding site and one tyrosine - containing motif induced c - Src activation as measured by a transcriptional reporter .",
            "output": [
                "c - Src"
            ]
        },
        {
            "id": "task1481-73246fd5f2eb4f8dad175c3e7b52f15c",
            "input": " Transforming growth factor - beta ( TGF - beta ) inhibits cell cycle progression , in part through up - regulation of gene expression of the p21 ( WAF1 / Cip1 ) ( p21 ) cell cycle inhibitor .",
            "output": [
                "TGF - beta"
            ]
        },
        {
            "id": "task1481-6ff9d785f43346a5949acb8b7a7e842f",
            "input": " Electrophoretic mobility - shift assays with nuclear extracts from COS - 1 cells transfected with expression vectors for SMADs 1 - 5 indicate that SMAD3 forms a complex with a migration similar to that of the endogenous TGF - beta - specific complex observed in fibroblast extracts .",
            "output": [
                "TGF - beta"
            ]
        },
        {
            "id": "task1481-dd26dbbfb85f4a368c53126e459828f0",
            "input": " Furthermore , CBP / p300 stimulated both TGF - beta - and Smad - induced transcription in a Smad4 / DPC4 - dependent fashion .",
            "output": [
                "TGF - beta"
            ]
        },
        {
            "id": "task1481-00de0f20207b453c9446c49ba1468716",
            "input": " In addition to TAK1 , TGF - beta also stimulated JNK activity .",
            "output": [
                "TGF - beta"
            ]
        },
        {
            "id": "task1481-d4d5d3b343cc4c3196a05fbb2cbff74a",
            "input": " Similarly , antisense TGF - beta type II receptor oligodeoxynucleotides ( 40 microM ) resulted in a 58 % increase in branching , compared to scrambled and mismatched sequence controls , while TGF - beta , type II receptor mRNA and its protein expression levels were suppressed by 95 and 84 % , respectively .",
            "output": [
                "TGF - beta"
            ]
        },
        {
            "id": "task1481-23961f4b93d64ff19d0705c1b1ffac9d",
            "input": " Transforming growth factor beta activates the promoter of cyclin - dependent kinase inhibitor p15INK4B through an Sp1 consensus site .",
            "output": [
                "Sp1 consensus site"
            ]
        },
        {
            "id": "task1481-2f4bc77d66b3469cba3d6b6b5d85f950",
            "input": " These mutant rps7 leaders were ligated into an aadA expression cassette and transformed into the chloroplast of C . reinhardtii and into E . coli .",
            "output": [
                "mutant rps7"
            ]
        },
        {
            "id": "task1481-f34f4032b4d94cea8c096c331b4568a8",
            "input": " YACs selected from our contig will be the starting point for the cloning of the LGMD2B gene and thereby establish the biological basis for this form of muscular dystrophy and its relationship with the other limb - girdle muscular dystrophies .",
            "output": [
                "LGMD2B gene"
            ]
        },
        {
            "id": "task1481-d25b08c40e114eba9022443f00eb2e2d",
            "input": " p107 induction of E2F DNA binding was observed primarily in S phase cells coincident with the increase in p107 protein levels .",
            "output": [
                "p107 protein"
            ]
        },
        {
            "id": "task1481-38f5dae257f749dd9507185312c448f9",
            "input": " Although indomethacin is useful for examining the role of cyclooxygenase products in asthmatic responses , it should not be considered in the treatment of asthma .",
            "output": [
                "cyclooxygenase products"
            ]
        },
        {
            "id": "task1481-4bfcf0ab5a0c47cfbc10d3979ee7e7d4",
            "input": " We have isolated and determined the complete nucleotide sequence of another operon , cpeCD , that encodes the linker proteins associated with phycoerythrin hexamers in the phycobilisome .",
            "output": [
                "phycoerythrin hexamers"
            ]
        },
        {
            "id": "task1481-a89920449c7c4443bd3b1bcc67d2a569",
            "input": " Oral basal body temperature ( BBT ) recordings of 46 women that conceived by donor insemination and who had midcycle monitoring of luteinising hormone ( LH ) were analysed to establish features associated with an optimal cycle .",
            "output": [
                "luteinising hormone"
            ]
        },
        {
            "id": "task1481-261a3dd86cc54e2d896d640815823032",
            "input": " Unlike these contaminant - responsive T cells , those that are truly specific for natural AChR epitopes appear less heterogeneous and therefore more suitable targets for selective immunotherapy .",
            "output": [
                "AChR epitopes"
            ]
        },
        {
            "id": "task1481-d57abe268c4d40259643652d99ef5dbe",
            "input": " Optical rotation of the second harmonic radiation from retinal in bacteriorhodopsin monomers in Langmuir - Blodgett film : evidence for nonplanar retinal structure .",
            "output": [
                "bacteriorhodopsin monomers"
            ]
        },
        {
            "id": "task1481-9dd83f86877e4f769d24f37f7b6c9ef5",
            "input": " Mutations abolishing MalK function not only result in inability to transport maltose but also cause constitutive expression of the maltose regulon .",
            "output": [
                "maltose regulon"
            ]
        },
        {
            "id": "task1481-5295626f79454e37b4b8a3e24d50ca88",
            "input": " Serum levels of angiotensin converting enzyme were well maintained .",
            "output": [
                "angiotensin converting enzyme"
            ]
        },
        {
            "id": "task1481-2ebd7e5d7c26474fb48bc809fb744eb0",
            "input": " To assess the safety of the angiotensin converting enzyme inhibitor enalapril a multicenter , open , randomized , prazosin - controlled trial was designed comparing the incidence and severity of symptomatic hypotension on the first day of treatment .",
            "output": [
                "angiotensin converting enzyme"
            ]
        },
        {
            "id": "task1481-23d22274cf654acdb6d398a9a554c118",
            "input": " The N - terminal sequence of the extracellular MEP20 , TKVAS , was found at aa 194 - 198 within the ORF .",
            "output": [
                "extracellular MEP20"
            ]
        },
        {
            "id": "task1481-7f2384dca5a94fcd9dd5360851ee049f",
            "input": " RESULTS : BMK - 1 and other 19 contents significantly decreased depolarization parameters Vmax , APA , OS , and MDP , which was similar to that of TTX and different from that of Nim and BaCl2 .",
            "output": [
                "BMK - 1"
            ]
        },
        {
            "id": "task1481-d741381134f84e66bf3e83aff4d87a11",
            "input": " By computed homology search , we noticed significant similarities between US3 PK and p21 - activated kinase ( PAK ) , which is activated by the Cdc42 or Rac .",
            "output": [
                "US3 PK"
            ]
        },
        {
            "id": "task1481-b63c39b8903d48cf8b27e8970d3356be",
            "input": " Cell rounding was abrogated by expression of either kinase - dead forms of US3 PK or a mutant protein lacking the acidic cluster in the kinase regulatory domain .",
            "output": [
                "US3 PK"
            ]
        },
        {
            "id": "task1481-9c42402ffb584e73b009da742cbc3b4e",
            "input": " Sequences within and flanking hypersensitive sites 3 and 2 of the beta - globin locus control region required for synergistic versus additive interaction with the epsilon - globin gene promoter .",
            "output": [
                "beta - globin"
            ]
        },
        {
            "id": "task1481-a01c231540734ed5b441b3af47be7720",
            "input": " Activation of the mitogen - activated protein kinase ( MAPK ) pathway enhances long - range transactivation by the beta - globin locus control region ( LCR ) ( W .",
            "output": [
                "beta - globin"
            ]
        },
        {
            "id": "task1481-59168fbb873b404aacb7004cc15012fb",
            "input": " These results point towards post - translational steric and / or allosteric control of EKLF function that may be important not just for its DNA binding ability , but also for its potential to interact with other proteins that fully establish the correct stereospecific array leading to efficient switching of beta - globin transcription during development .",
            "output": [
                "beta - globin"
            ]
        },
        {
            "id": "task1481-9f7db82e0a5f4b22b68a3cc7022d62b9",
            "input": " Herein , we report that CRE - decoy oligonucleotide treatment results in an increase in the p53 protein level in MCF - 7 human breast cancer cells that express wild - type p53 .",
            "output": [
                "p53 protein"
            ]
        },
        {
            "id": "task1481-1654a40f4d8e469e89ffe48b44dc4477",
            "input": " Reduction of p53 protein was detected after 1 day of OM treatment and reached maximal suppression of 10 - 20 % of control after 3 days in H3922 and 40 % of control after 4 days in MCF - 7 cells .",
            "output": [
                "p53 protein"
            ]
        },
        {
            "id": "task1481-8cc9fa63a51a4c65bb0b6a2b00efe408",
            "input": " However , only plasma fibrinogen concentrations showed statistically significant positive associations with IMT in both groups .",
            "output": [
                "plasma fibrinogen"
            ]
        },
        {
            "id": "task1481-8c5ab9e00efe454eaf24209eb8733288",
            "input": " ET - 1 limited the electrocardiographic evidence of subendocardial ischemia and attenuated contractile dysfunction compared with mechanical stenosis at the same coronary flows , even though lactate flux was similar .",
            "output": [
                "ET - 1"
            ]
        },
        {
            "id": "task1481-220e0ab4ee0142d0893163d6190275f9",
            "input": " Uptake of colicins required different domains in TonB , for colicin B and M around residue 160 and for colicin Ia , a domain closer to the C - terminal end .",
            "output": [
                "colicin Ia"
            ]
        },
        {
            "id": "task1481-20c84696eb684b21a58db319cd4abb34",
            "input": " To study the mechanisms and the signaling pathways involved , IGF - 1R promoter reporter constructs were transiently transfected in CHO - AT1 cells that overexpress angiotensin AT1 receptors .",
            "output": [
                "angiotensin AT1 receptors"
            ]
        },
        {
            "id": "task1481-75287c78fd044d2f8dcb1b2b706fa6df",
            "input": " These clones contain most of the exon of cyclin D2 except exon 5 .",
            "output": [
                "cyclin D2"
            ]
        },
        {
            "id": "task1481-16b0132febb54dae88913f88b276916c",
            "input": " Although no detectable phenotypes are associated with a disruption allele of ABP1 , mutations that create a requirement for this protein have now been isolated in the previously identified gene SAC6 and in two new genes , SLA1 and SLA2 .",
            "output": [
                "gene SAC6"
            ]
        },
        {
            "id": "task1481-a0f40f6cc8974b1fa349793e872b00aa",
            "input": " Second , CGGA - containing sequences placed at - 88 in the delta MTV - CAT reporter plasmid conferred insulin responsiveness to the mammary tumor virus promoter .",
            "output": [
                "CAT reporter"
            ]
        },
        {
            "id": "task1481-ae4cfaff5d5648a0af2cd47febabca6b",
            "input": " This ligand - independent pathway can function through another androgen - regulated promoter as shown by the use of the mouse mammary tumor virus MMTV - CAT reporter .",
            "output": [
                "CAT reporter"
            ]
        },
        {
            "id": "task1481-4d6966e1d5e0490c88978cac57b4cf01",
            "input": " In addition , because SB203580 had no effect of TNF - or ceramide - induced apoptosis , our results strongly argue against a role for p38 MAPK in the induction of TNF - - or ceramide - induced apoptosis .",
            "output": [
                "p38 MAPK"
            ]
        },
        {
            "id": "task1481-0b4bc0535ecc486f8e533492f71de63c",
            "input": " Although paclitaxel alone failed to induce p38 MAPK activation , subsequent ( but not prior ) exposure to PD98059 induced a dramatic increase in p38 MAPK phosphorylation .",
            "output": [
                "p38 MAPK"
            ]
        },
        {
            "id": "task1481-63fa7135d0b6473a81c8272a195231b0",
            "input": " These data indicate that SB 203580 sensitive p38 MAP kinases are not involved in okadaic acid mediated increases in TRE DNA binding and transactivation .",
            "output": [
                "p38 MAP kinases"
            ]
        },
        {
            "id": "task1481-479d41a6bf5a49488a7c47a0be81b0d2",
            "input": " It competes with the calcium ion which brings about inhibition of myosine kinase , and therefore a drop in phosphorylated myosine .",
            "output": [
                "myosine kinase"
            ]
        },
        {
            "id": "task1481-3ff6bae14632411a85a6b264546fff14",
            "input": " Previously identified mutations in this variant have been within or close to the coding region of exon 1 of the HMBS gene , the only exon that is expressed solely in the ubiquitous isoform .",
            "output": [
                "HMBS gene"
            ]
        },
        {
            "id": "task1481-69a65829ffc54d6c8fd3ac4e052d03e1",
            "input": " In contrast , corticotropin releasing factor ( CRF ) , injected centrally produces a suppression of punished and non - punished responding in the conflict test consistent with its hypothesized role in mediating behavioral responses to stress .",
            "output": [
                "corticotropin releasing factor"
            ]
        },
        {
            "id": "task1481-faad85823f1f407d93c9700e0cac7a38",
            "input": " Sequence analysis revealed 100 % homology of all RA - derived PTEN fragments to those from normal SF as well as to the published GenBank sequence ( accession number U93051 ) .",
            "output": [
                "PTEN fragments"
            ]
        },
        {
            "id": "task1481-dfc2293556c24b9f8272614c0d59e9a7",
            "input": " Previous work has shown that glucose repression of PRB1 transcription is not mediated by HXK2 or by the SNF1 , SNF4 , and SNF6 genes ( C .",
            "output": [
                "SNF6 genes"
            ]
        },
        {
            "id": "task1481-8d1dc61e76ca4177bef4c20ec7c63ca9",
            "input": " Like troponin Cs and calmodulins , PfCPK also contains four EF hand calcium - binding motifs .",
            "output": [
                "troponin Cs"
            ]
        },
        {
            "id": "task1481-86aa7a7574f34779aa85229764103c16",
            "input": " Hpr1 forms , together with Tho2 , Mft1 , and Thp2 , the THO complex , which controls transcription elongation and genome stability in Saccharomyces cerevisiae .",
            "output": [
                "THO complex"
            ]
        },
        {
            "id": "task1481-9af6c8bbf1db422b915a96c18fd56ff1",
            "input": " Like other IAPs , ch - IAP1 contains the N - terminal baculovirus IAP repeats and C - terminal RING finger motifs .",
            "output": [
                "ch - IAP1"
            ]
        },
        {
            "id": "task1481-db46a4e19592480cace97bab4ce55244",
            "input": " Visualization of the cells by phase contrast microscopy indicated that murine PKCepsilon expression in the presence of glycerol resulted in a significant increase in the number of yeast cells exhibiting very small buds .",
            "output": [
                "murine PKCepsilon"
            ]
        },
        {
            "id": "task1481-0dc28cda1e61431e9dcd89422025b6ec",
            "input": " Comparison of the predicted amino acid sequence with that of the Drosophila virilis gene shows that several blocks of amino acid sequence have been very highly conserved .",
            "output": [
                "Drosophila virilis gene"
            ]
        },
        {
            "id": "task1481-c11713a5a9bb4deea37b66f9696833d3",
            "input": " A 5789 - nucleotide - long EcoRI fragment from the genome of Thermotoga maritima , identified by cross - hybridization to L11 , L1 , L10 , and L12 ribosomal protein gene sequences from Escherichia coli , was cloned and sequenced .",
            "output": [
                "EcoRI fragment"
            ]
        },
        {
            "id": "task1481-f9ad126e9f6f4370a44619ad0d180e4f",
            "input": " The 7 . 2 kb EcoRI fragment of AfMNPV was cloned and the nucleotide sequences of the polyhedrin coding region and its flanking regions were determined .",
            "output": [
                "EcoRI fragment"
            ]
        },
        {
            "id": "task1481-bb0f188d841046b7a5df056732a5d931",
            "input": " Restriction mapping showed that the two recombinant plasmids shared an EcoRI fragment of 8 . 9 kb .",
            "output": [
                "EcoRI fragment"
            ]
        },
        {
            "id": "task1481-28cbace02bdc449a9d8c2a3eacf6c96a",
            "input": " Such tetranucleotides are common in promoter regions , particularly in activating transcription factor / cyclic AMP response element - binding protein ( ATF / CREB ) and E - box motifs , suggesting that PIF may modulate the transcription of many genes .",
            "output": [
                "activating transcription factor"
            ]
        },
        {
            "id": "task1481-abd9de6df918453e968b55e0b0f07a0c",
            "input": " Characterization of human activating transcription factor 4 , a transcriptional activator that interacts with multiple domains of cAMP - responsive element - binding protein ( CREB ) - binding protein .",
            "output": [
                "activating transcription factor"
            ]
        },
        {
            "id": "task1481-ca5fbbf30c46402b83b1f40a6e5da85a",
            "input": " Regulation of activating transcription factor - 1 and the cAMP response element - binding protein by Ca2 + / calmodulin - dependent protein kinases type I , II , and IV .",
            "output": [
                "activating transcription factor"
            ]
        },
        {
            "id": "task1481-3cdf84df70114ff99de84072ac54432b",
            "input": " Increased gliadin antibody levels were found more frequently in patients with subtotal villous atrophy ( 9 out of 17 patients , or 53 % ; p less than 0 . 05 ) than in patients with partial villous atrophy ( 2 out of 13 patients , or 15 % ) or normal villous appearance ( 2 out of 10 patients , or 20 % ) .",
            "output": [
                "gliadin antibody"
            ]
        },
        {
            "id": "task1481-65f9dcaf90b7432183d1a1362a7b5aae",
            "input": " Action against Vibrio cholerae O1 Tox + of chemical products used in the lemon production .",
            "output": [
                "Tox +"
            ]
        },
        {
            "id": "task1481-af5c9e03453949598929b0310bb1d8b2",
            "input": " Our results are consistent with TCOF1 mutations leading to the Treacher Collins syndrome phenotype .",
            "output": [
                "TCOF1 mutations"
            ]
        },
        {
            "id": "task1481-b1e061164726479c959aa55c8ed3c1ca",
            "input": " Although mutant pex5delta cells expressing a yeast / tobacco Pex5p chimaera failed to import a GFP - Eci1p reporter protein , they were able to grow on oleic acid .",
            "output": [
                "mutant pex5delta"
            ]
        },
        {
            "id": "task1481-97bfbc24f2f3489f9d1f8d3562da4bc2",
            "input": " Two genes ( ptsI and ptsA ) that encode homologues of the energy coupling Enzyme I of the phosphoenolpyruvate - dependent sugar - transporting phosphotransferase system ( PTS ) have previously been identified on the Escherichia coli chromosome .",
            "output": [
                "Enzyme I"
            ]
        },
        {
            "id": "task1481-6ca13aee4b7c40f5ab257bedac150a7f",
            "input": " It contains 31 exons and a high proportion of class 0 introns , alternative splicing of which results in significant levels of variant transcripts that maintain the original open reading frame of MRP mRNA .",
            "output": [
                "MRP mRNA"
            ]
        },
        {
            "id": "task1481-5e3a43130d5043939e601aab107c6d25",
            "input": " Hepatocyte growth factor ( HGF ) is an inducible cytokine that is essential for the normal growth and development of various tissues , such as the liver .",
            "output": [
                "Hepatocyte growth factor"
            ]
        },
        {
            "id": "task1481-cb58baaedc6048dd9050dc54f9f77734",
            "input": " The protein encoded by the NF2 gene has a similarity to ezrin , radixin and moesin ( ERM ) proteins that link membrane proteins to the cytoskeleton .",
            "output": [
                "NF2 gene"
            ]
        },
        {
            "id": "task1481-e5a60c3d4a7041e484a5b2ffcfb1b22f",
            "input": " The dopamine D1 dopamine receptor antagonist SCH 23390 dose dependently ( 7 . 5 - 30 micrograms / kg s . c . ) antagonized the stimulant locomotor effect on both drugs but did not prevent their antiimmobility effect on the behavioral despair test .",
            "output": [
                "dopamine receptor"
            ]
        },
        {
            "id": "task1481-2c0e2146ddf345a593fdf6b1a9dad6c7",
            "input": " It is concluded that the predominant action of LSD on the female copulatory response is not mediated by increased dopamine receptor activity but that the LSD effect might be modulated by decreased dopaminergic activity .",
            "output": [
                "dopamine receptor"
            ]
        },
        {
            "id": "task1481-9f59bce5878a4178ae0a975011abde6e",
            "input": " claR and car were not significantly expressed in mutants disrupted in the ccaR gene , a regulatory gene that controls positively clavulanic acid and cephamycin biosynthesis .",
            "output": [
                "ccaR gene"
            ]
        },
        {
            "id": "task1481-e628e906e0bf4184acb733b96d555dda",
            "input": " RNase protection analysis reveals a 10 - fold increase in the expression of SCD2 mRNA during 3T3 - L1 preadipocyte differentiation .",
            "output": [
                "SCD2 mRNA"
            ]
        },
        {
            "id": "task1481-ff5a023fb4bd444887307916b396ce16",
            "input": " The levels of TPAR1 mRNAs were dramatically down - regulated in regenerating rat liver when compared to normal adult liver .",
            "output": [
                "TPAR1 mRNAs"
            ]
        },
        {
            "id": "task1481-d15a2558e9e74caaa20e372b5bd99e81",
            "input": " Furthermore , the data suggest an immunological non - responsiveness to enterotoxin A in a considerable portion of the patients .",
            "output": [
                "enterotoxin A"
            ]
        },
        {
            "id": "task1481-fb41feda4b8149a9a87b3e5e44888b89",
            "input": " Further studies aim at characterizing the trans - acting factors that mediate the spatial and temporal expression of Hox genes in the developing embryo .",
            "output": [
                "Hox genes"
            ]
        },
        {
            "id": "task1481-1ecbeb17137948d0bac98a4dc7161314",
            "input": " Sugar analysis was performed on alpha - TM to investigate a possible biosynthetic mechanism for part - time PGs .",
            "output": [
                "alpha - TM"
            ]
        },
        {
            "id": "task1481-e18e0c3da28b4dadb582c7dab9d0e61f",
            "input": " P53 mutations also offer new approaches to the study of the origins of mutations in human cancer .",
            "output": [
                "P53 mutations"
            ]
        },
        {
            "id": "task1481-22b78d3fd5164223848f9053cb179a0f",
            "input": " In situ hybridization of whole - mount mouse embryos with Mex5 antisense RNA provide no evidence for the exclusion of Mex5 during embryonic development .",
            "output": [
                "Mex5 antisense RNA"
            ]
        },
        {
            "id": "task1481-4a79516aca7c47bf9e3a69e960c2e661",
            "input": " The sequence of the 127 residue NrfF polypeptide , M ( r ) 14 , 522 , is strikingly similar to the CcI2 protein of R . capsulatus , especially in the putative haem - binding motif , RCPQCQNQN . ( ABSTRACT TRUNCATED AT 400 WORDS )",
            "output": [
                "CcI2 protein"
            ]
        },
        {
            "id": "task1481-8831adb0eeba48a8aa6c3a5832783173",
            "input": " A novel Cdc42Hs mutant induces cellular transformation .",
            "output": [
                "Cdc42Hs mutant"
            ]
        },
        {
            "id": "task1481-edb07fc2f4134c4cb2405bc3d3844c0a",
            "input": " The vaccinia virus D6R open reading frame encodes the small subunit of the heterodimeric vaccinia virus early transcription factor ( VETF ) that activates transcription of early genes in vitro .",
            "output": [
                "early genes"
            ]
        },
        {
            "id": "task1481-a2266dfbb5164f2d9179cd581146dc24",
            "input": " In addition , Fc epsilon R1 cross - linking activates PI 3 - kinase .",
            "output": [
                "Fc epsilon R1"
            ]
        },
        {
            "id": "task1481-d3a1c640f4a74d75a0e76dae666fff66",
            "input": " Its phosphorylation strongly potentiates its ability to activate transcription of the c - fos promoter through a ternary complex assembled on the c - fos serum response element .",
            "output": [
                "c - fos"
            ]
        },
        {
            "id": "task1481-4266a1a94236434c817443223e7c185d",
            "input": " Basic helix - loop - helix proteins can act at the E - box within the serum response element of the c - fos promoter to influence hormone - induced promoter activation in Sertoli cells .",
            "output": [
                "c - fos"
            ]
        },
        {
            "id": "task1481-1bb85351bbdb484eb54fe0e0e7648d6d",
            "input": " Rac2 , a member of the Rho family of GTPases , is highly expressed in myeloid cells and is a regulator of the NADPH - oxidase complex .",
            "output": [
                "Rho family"
            ]
        },
        {
            "id": "task1481-4161a8cb60c44d8f9246cdffc1edfa95",
            "input": " RESULTS : All primary tumors were positive for CAM5 . 2 .",
            "output": [
                "CAM5 . 2"
            ]
        },
        {
            "id": "task1481-b0de38e55443480a9909f90be5cc4c25",
            "input": " Serum angiogenin concentrations in young patients with diabetes mellitus .",
            "output": [
                "Serum angiogenin"
            ]
        },
        {
            "id": "task1481-f9897ea74d4c43e7a7a33296e6ac71b8",
            "input": " When severe hypoxia was acutely produced by ventilation with low - oxygen mixtures in experimental ( PaO2 , 23 . 7 + / - 1 . 7 torr ) and control animals ( PaO2 , 26 . 3 + / - 1 . 0 torr ) , plasma insulin responses were markedly inhibited in both .",
            "output": [
                "plasma insulin"
            ]
        },
        {
            "id": "task1481-4f87bd57385b47afa84183bce2db006b",
            "input": " Effect of age on glucose , reducing sugars and plasma insulin in blood of milk - fed calves .",
            "output": [
                "plasma insulin"
            ]
        },
        {
            "id": "task1481-469cdff76b3143f4b70c9d9b12053763",
            "input": " The full - length cDNA was cloned and sequenced , and the inferred amino acid sequence was found to encode a novel protein , which we named cystatin M , with 40 % homology to human family 2 cystatins and similar overall structure .",
            "output": [
                "cystatin M"
            ]
        },
        {
            "id": "task1481-2241607c53da4734ad7a7981b9cb05cc",
            "input": " These cells also showed an increase in cyclin A and cyclin A - and E - associated kinase activities characteristic of S phase induction .",
            "output": [
                "cyclin A"
            ]
        },
        {
            "id": "task1481-a53a0525f49a406c9e42be0c9171851b",
            "input": " The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4 / U6 snRNP , a component of the mRNA splicing apparatus .",
            "output": [
                "PRP4 protein"
            ]
        },
        {
            "id": "task1481-16daa73ae72b4956b67c213ff74b34b8",
            "input": " METHODS : Levels of sIL - 2R were measured simultaneously in plasma and pleural fluid in 111 patients with pleural effusions of unknown causes .",
            "output": [
                "sIL - 2R"
            ]
        },
        {
            "id": "task1481-5840cb68689541c1a84c5baab057d8db",
            "input": " After 3 months of intervention , sustained physical training was associated with the decrease of FVII and PAI - 1 levels .",
            "output": [
                "PAI - 1"
            ]
        },
        {
            "id": "task1481-73859785fcd84928a45c27fa16699fc4",
            "input": " High and pathological PAI - 1 levels before and after the VO test were consistent with a defective fibrinolytic potential due to the inhibitory effect of PAI - 1 on plasminogen activation .",
            "output": [
                "PAI - 1"
            ]
        },
        {
            "id": "task1481-f5074eadb85f4b718ca1630bc74c6f91",
            "input": " The remaining 77 nucleotides at the 3 ' end of domain II and all of domains III ( 655 nucleotides ) and IV ( 770 nucleotides ) are not present in DIssE RNA .",
            "output": [
                "DIssE RNA"
            ]
        },
        {
            "id": "task1481-632ebb8f91ca490684236301baa21a3f",
            "input": " Serum alpha - amylase , trypsin , trypsin inhibitor , lipase and total protease activity in the pancreatic tissue was studied as indicator of the treatment efficacy with 5 - fluorouracil electro - cumulation .",
            "output": [
                "trypsin inhibitor"
            ]
        },
        {
            "id": "task1481-334c136900274c53882cf2623047ece4",
            "input": " Nicotinic receptor antagonists mecamylamine ( 0 . 5 and 1 mg / kg ) and hexamethonium ( 5 and 10 mg / kg ) reduced the response induced by nicotine ( 0 . 25 mg / kg ) .",
            "output": [
                "Nicotinic receptor"
            ]
        },
        {
            "id": "task1481-fd315f8467d44b849a25e5daf1400961",
            "input": " Comparison of the encoded ERCC3Dm protein with the homologous proteins of mouse and man shows a strong amino acid conservation ( 71 % identity ) , especially in the postulated DNA binding region and seven ' helicase ' domains .",
            "output": [
                "ERCC3Dm protein"
            ]
        },
        {
            "id": "task1481-84d21a29f3d64ecaa1d1b42cc8a2ff66",
            "input": " BACKGROUND - - Platelet activating factor ( PAF ) has been implicated in the pathogenesis of airway hyperresponsiveness in asthma .",
            "output": [
                "Platelet activating factor"
            ]
        },
        {
            "id": "task1481-eaf11b74c8d04191b9a8904e928d6f9a",
            "input": " Although several other signal transduction molecules also contain tandemly occurring SH3 and SH2 domains , the function of these closely spaced domains is not well understood .",
            "output": [
                "SH2 domains"
            ]
        },
        {
            "id": "task1481-1444bef227024bc598c40e3880af2811",
            "input": " In addition , putative binding sites for SH3 and SH2 domains are present in the amino - terminal half of the molecule .",
            "output": [
                "SH2 domains"
            ]
        },
        {
            "id": "task1481-773e53e8f4e943ff9e05f11ec179039e",
            "input": " Detailed comparison of the sequences of cp35 and human calpactin II shows that the only substantial sequence dissimilarity is a domain encoding amino acids between residues 20 and 40 which includes a tyrosine phosphorylation site in the human molecule , along with other residues of possible physiological significance .",
            "output": [
                "human calpactin II"
            ]
        },
        {
            "id": "task1481-49a065c5f97d435c94ea17d442078a63",
            "input": " We provided evidence that CaM kinase II played a role in regulating neurite outgrowth and growth cone motility in these cells , and that the autophosphorylation is essential for the kinase to sufficiently exert its cellular function in vivo [ Y .",
            "output": [
                "CaM kinase II"
            ]
        },
        {
            "id": "task1481-e8a39c80b57847b6811cf25dfe6b7b8d",
            "input": " When yeast cells reach a critical size in late G1 they simultaneously start budding , initiate DNA synthesis , and activate transcription of a set of genes that includes G1 cyclins CLN1 , CLN2 , and many DNA synthesis genes .",
            "output": [
                "G1 cyclins"
            ]
        },
        {
            "id": "task1481-72fe875f350045cfa8427842160417b0",
            "input": " Thus , an unmodified threonine at position 169 in Cdc28 is important for interaction with G1 cyclins .",
            "output": [
                "G1 cyclins"
            ]
        },
        {
            "id": "task1481-e7cccd12a06b41eb8da624771fb9949f",
            "input": " The predicted amino - acid sequence includes an N - terminal signal sequence of 27 amino acids , a 27 amino - acid pro - region , a 251 amino - acid catalytic domain typical of a serine protease with trypsin - like specificity , and a C - terminal hydrophobic extension which is predicted to function as a membrane anchor .",
            "output": [
                "serine protease"
            ]
        },
        {
            "id": "task1481-08d54e103d654dd7a3fb2174d5c6cda8",
            "input": " In those patients who before transplantation were serological negative for CMV but had received organs from CMV - IgG positive donors , the incidence of the disease was highest .",
            "output": [
                "CMV - IgG"
            ]
        },
        {
            "id": "task1481-09bf60f4d47f4155aab55fb4ea2a8fa4",
            "input": " The TCR beta enhancer was active on both the minimal simian virus 40 promoter and a TCR beta variable gene promoter in both TCR alpha / beta + and TCR gamma / delta + T cells .",
            "output": [
                "TCR beta enhancer"
            ]
        },
        {
            "id": "task1481-bac823e97af14742969d20d60470f76c",
            "input": " The genomic organization in this region is similar to the neural - restricted family members , Hel - N1 ( ELAVL2 ) and mHuD ( Elavl4 ) .",
            "output": [
                "Hel - N1"
            ]
        },
        {
            "id": "task1481-eab7effbd53d44eba67adee9cdb3692c",
            "input": " Analysis of pseudo VH gene segment recombination products reveals no bias in D gene segment reading frame utilization .",
            "output": [
                "D gene segment"
            ]
        },
        {
            "id": "task1481-3d052ca1dd274f7ea644b7dbf1661aa4",
            "input": " Detailed analysis of the predicted amino acid sequence revealed sequence elements which are conserved in many DNA and RNA polymerases .",
            "output": [
                "RNA polymerases"
            ]
        },
        {
            "id": "task1481-b06d2f7b74b8434f82edea692a2ed41d",
            "input": " Rhinovirus 2A protease and foot - and - mouth - disease virus L protease were used to analyze the association of eIF4G with eIF4A , eIF4E , and eIF3 .",
            "output": [
                "Rhinovirus 2A protease"
            ]
        },
        {
            "id": "task1481-e4e9a25961d2435c9044d7f5bcc83c9d",
            "input": " We now show that purified recombinant c - sis / PDGF can induce this binding activity which we have termed SIF , for sis - inducible factor .",
            "output": [
                "c - sis"
            ]
        },
        {
            "id": "task1481-c85c5f683c0c413d8479a6c5b500b62b",
            "input": " These proteins , called variant surface glycoproteins ( VSGs ) , are expressed from a specific locus , the VSG gene expression site ( ES ) .",
            "output": [
                "variant surface glycoproteins"
            ]
        },
        {
            "id": "task1481-774868a6bda043c497935d2bfd87e163",
            "input": " Recombinant protein encoded by ESX ( for epithelial - restricted with serine box ) exhibits Ets - like DNA binding specificity in electrophoretic mobility shift assays and , in transient transfection assays , transactivates Ets - responsive promoter elements including that found in the HER2 / neu oncogene .",
            "output": [
                "Ets - like"
            ]
        },
        {
            "id": "task1481-f7cb189ca22142468555a403d5f5abf3",
            "input": " Immunoblot analysis of purified and protease - digested intracellular mature virus ( IMV ) and extracellular enveloped virus ( EEV ) showed that the A36R proteins were present on the surface of EEV with type II membrane topology , but were absent from IMV .",
            "output": [
                "A36R proteins"
            ]
        },
        {
            "id": "task1481-7aba35457a114838ab73fed0a71159dd",
            "input": " Among women , plasma factor VII : Ag was inversely associated with income .",
            "output": [
                "plasma factor VII"
            ]
        },
        {
            "id": "task1481-24cc76c09fdd46c08e15c18e49391bc4",
            "input": " To initiate our analysis of factors required for eIF - 2 alpha expression , selected a CAP - proximal element shown by in vivo methylation protection analysis to bind a potential regulatory factor .",
            "output": [
                "eIF - 2"
            ]
        },
        {
            "id": "task1481-9deddb34b2bd4883ae3d881c8a56bef7",
            "input": " A wide conservation of iscSUA genes in nature and evidence that NifU and NifS participate in the mobilization of iron and sulfur for nitrogenase - specific iron - sulfur cluster formation suggest that the products of the iscSUA genes could play a general role in the formation or repair of iron - sulfur clusters .",
            "output": [
                "iscSUA genes"
            ]
        },
        {
            "id": "task1481-11bd52757af646eaa25c013e964d7df9",
            "input": " In addition , mutations within the Ubx unit exons are known and most of these behave as null alleles .",
            "output": [
                "Ubx unit exons"
            ]
        },
        {
            "id": "task1481-5969c01dfb614da6b22bcd665333c593",
            "input": " The authors suggest that alprazolam may have enhanced specificity for a subpopulation of benzodiazepine receptors .",
            "output": [
                "benzodiazepine receptors"
            ]
        },
        {
            "id": "task1481-a8f2b7e5b94f4ff087909b24a023424b",
            "input": " Interestingly , unlike PAK65 , HPK1 does not contain the small GTPase Rac1 / Cdc42 - binding domain and does not bind to either Rac1 or Cdc42 , suggesting that HPK1 . activation is Rac1 / Cdc42 - independent .",
            "output": [
                "small GTPase"
            ]
        },
        {
            "id": "task1481-97b3b89c2b604b1c9db85dba481084bc",
            "input": " We functionally characterised AtXPO1 by its interaction with NESs of animal and plant proteins , which is inhibited by the cytotoxin leptomycin B ( LMB ) , and also by its interaction with the small GTPase Ran1 in the yeast two - hybrid system .",
            "output": [
                "small GTPase"
            ]
        },
        {
            "id": "task1481-8da9a7eb23c3401da01c081d7aef8f61",
            "input": " Therefore , it appears that GCN2 protein kinase function is stimulated posttranslationally in amino acid - starved cells .",
            "output": [
                "GCN2 protein kinase"
            ]
        },
        {
            "id": "task1481-5102dadec5dc4f99910b0dc19c786ea4",
            "input": " From the deduced amino acid sequence , a molecular weight of 38 , 549 was calculated for the ADH subunit .",
            "output": [
                "ADH subunit"
            ]
        },
        {
            "id": "task1481-de02258d1d7b499aba5b5e44b85e37ff",
            "input": " The analysis predicted that progressive increases in serum creatinine or aspartate transaminase activity will result in only a 50 % reduction of clearance .",
            "output": [
                "aspartate transaminase"
            ]
        },
        {
            "id": "task1481-5e9ef3a23c4343e28d8aaa602b1e09bb",
            "input": " In contrast , the holo - dTFIIA ( L / S ) binds TBP with high affinity .",
            "output": [
                "holo - dTFIIA"
            ]
        },
        {
            "id": "task1481-0e5c641889914672b8618beeb969e5b3",
            "input": " Prematurely inactivating p42 MAPK in egg extracts resulted in a corresponding hastening of the first mitosis .",
            "output": [
                "p42 MAPK"
            ]
        },
        {
            "id": "task1481-d869ff3b99a0480c9ee83d852ab764b6",
            "input": " Suppression of the cka1 delta cka2 - 8 mutant phenotype occurs by interaction of CKB1 with the defective , cka2 - 8 - encoded , catalytic subunit .",
            "output": [
                "cka2 - 8"
            ]
        },
        {
            "id": "task1481-a12a02dbccec42c09b01d1705d54f3cc",
            "input": " Previous studies showed that a palindromic sequence located at - 159 base pairs is essential for induction of cutinase gene in Fusarium solani f .",
            "output": [
                "cutinase gene"
            ]
        },
        {
            "id": "task1481-af68cb15b3114a1ebf571ae8a548e5fe",
            "input": " Given a rapid induction of Egr - 1 on stimulation with growth factors or injury , these findings may represent at least one of the molecular mechanisms underlying phenotypic modulation of smooth muscles after vascular injury .",
            "output": [
                "Egr - 1"
            ]
        },
        {
            "id": "task1481-6ed02794a1f848e2ab8cdf76f200bf3c",
            "input": " The originally embryonic gamma - globin locus duplicated and acquired a novel ( fetal ) pattern of expression in a defined time period ( 55 - 40 million years ago ) during primate phylogeny .",
            "output": [
                "gamma - globin"
            ]
        },
        {
            "id": "task1481-83120b9cf7ba48e3b17bbed8d86655b1",
            "input": " Analysis of the 5 ' and 3 ' termini of the transcripts produced in vivo from the puf operon of R . sphaeroides PUF delta 348 - 420 ( three transcripts ; 0 . 59 , 0 . 64 , and 2 . 63 kilobases ) lacking the puf - intercistronic terminator structure were identical to those of the corresponding puf transcripts derived from wild - type R . sphaeroides 2 . 4 . 1 ( four transcripts ; 0 . 50 , 0 . 66 , 0 . 71 , and 2 . 7 kilobases ) showing that the transcripts begin and end at the same sites .",
            "output": [
                "puf transcripts"
            ]
        },
        {
            "id": "task1481-e3a49e9a4a2b47ffa21f5201c962918e",
            "input": " BACKGROUND : Peripheral kappa receptor agonists may provide a new therapeutic approach for the treatment of functional dyspepsia .",
            "output": [
                "kappa receptor"
            ]
        },
        {
            "id": "task1481-163e71a9c46942d7b5d3357db19328a9",
            "input": " Using green fluorescent protein fusions we demonstrate that the SYT , SSX and the SYT - SSX proteins are nuclear proteins .",
            "output": [
                "green fluorescent protein"
            ]
        },
        {
            "id": "task1481-1802561d08954f078a9278c71b4ec4f4",
            "input": " K562 erythroleukemia cells stably transfected with constructs containing the human Agamma - globin promoter linked to an enhanced green fluorescent protein ( EGFP ) reporter , with or without HS2 , were analyzed for EGFP expression by flow cytometry .",
            "output": [
                "green fluorescent protein"
            ]
        },
        {
            "id": "task1481-eb01319bec2244c9b7290f2a951541c6",
            "input": " Paradoxically , loop 3i from the M1Ach - muscarinic receptor also maximally inhibited GnRH agonist - stimulated cAMP accumulation and PRL release by 40 % ( both effects mediated through activation of the Gs protein ) .",
            "output": [
                "Gs protein"
            ]
        },
        {
            "id": "task1481-b76b4877317b4338b7a2cfb63db207c2",
            "input": " We identified Tyr ( 112 ) and Leu ( 175 ) within the RNA - binding domain of the U1 70K protein to be cross - linked to G ( 28 ) and U ( 30 ) in stem - loop I , respectively .",
            "output": [
                "U1 70K protein"
            ]
        },
        {
            "id": "task1481-39f5165a74ff4146befcbc4f77931c0e",
            "input": " A wound model for decubitus and leg ulcers consisting of human dermal fibroblasts in type I collagen dermal \" equivalent \" matrix ( DEM ) was exposed in vitro to electric fields similar to postulated endogenous fields in wounds .",
            "output": [
                "type I collagen"
            ]
        },
        {
            "id": "task1481-c315f9a4c54b4cb4a8be6c08b802c0df",
            "input": " We conclude from these observations that the cTnC 3 ' Ile element is a composite enhancer that functions through the combined interactions of at least five regulatory elements and their cognate binding factors : three or four E - boxes , a MEF - 2 site , and a MEF - 3 site .",
            "output": [
                "MEF - 2"
            ]
        },
        {
            "id": "task1481-ef855a0010b84c409a37bf181fc210f2",
            "input": " The MEF - 2 proteins are a family of transcriptional activators that have been detected in a wide variety of cell types .",
            "output": [
                "MEF - 2"
            ]
        },
        {
            "id": "task1481-d1536129ba9b4ebcb89453b8124993ac",
            "input": " Oligomers corresponding to the region of the mlc - 1 / 3 enhancer , which encompasses this conserved sequence , bound MEF - 2 and competed for its binding to the mck enhancer .",
            "output": [
                "MEF - 2"
            ]
        },
        {
            "id": "task1481-d6d2fde2ff014ccb8de42d4ea1b958ff",
            "input": " These morphological changes are associated with a marked induction of P450arom gene expression .",
            "output": [
                "P450arom gene"
            ]
        },
        {
            "id": "task1481-3a6f0dab60e443bba9520e7510bf0330",
            "input": " We have previously reported the first isolation of a c - myc - null cell line .",
            "output": [
                "c - myc"
            ]
        },
        {
            "id": "task1481-ee95a23ba0c04d5988942a68d00f88e1",
            "input": " Mad3 and Mad4 : novel Max - interacting transcriptional repressors that suppress c - myc dependent transformation and are expressed during neural and epidermal differentiation .",
            "output": [
                "c - myc"
            ]
        },
        {
            "id": "task1481-dde05e5241a74fd2b3fb178fb7c3bccd",
            "input": " ER and DR were significantly correlated with MIB - 1 LI ( P < 0 . 01 and P < 0 . 05 , respectively ) , but RI and Td / Te were not .",
            "output": [
                "MIB - 1"
            ]
        },
        {
            "id": "task1481-5effaccfbcc143ea84a3ebe426be16e5",
            "input": " The proliferative potential of the pilocytic astrocytoma : the relation between MIB - 1 labeling and clinical and neuro - radiological follow - up .",
            "output": [
                "MIB - 1"
            ]
        },
        {
            "id": "task1481-8c9eac97e4484608aa5c642f2a56372e",
            "input": " We concluded that RXR - gamma induced terminal differentiation in SCC lines , suggesting a potential tumor suppressor function for this transcription factor .",
            "output": [
                "RXR - gamma"
            ]
        },
        {
            "id": "task1481-661f3dd2fda848a2abebc693fb8a5300",
            "input": " Although they are similar to the IL9R gene ( approximately 90 % identity ) , none of these copies encodes a functional receptor : none of them contains sequences homologous to the 5 ' flanking region or exon 1 of the IL9R gene , and the remaining ORFs have been inactivated by various point mutations and deletions .",
            "output": [
                "IL9R gene"
            ]
        },
        {
            "id": "task1481-da1b566cff3d458ab0b595a1e16f7ef4",
            "input": " Plasma renin activity in end - stage kidney disease .",
            "output": [
                "Plasma renin"
            ]
        },
        {
            "id": "task1481-a026e1a9cb8546efb9fc7c2a42b8a1f0",
            "input": " Plasma renin activity in essential arterial hypertension .",
            "output": [
                "Plasma renin"
            ]
        },
        {
            "id": "task1481-a6401613f7cd42559cec28471d26d257",
            "input": " Furthermore , the induction of cytochrome P - 450 1A1 observed in the cormorant indicates that the Ah receptor - mediated process , by which TCDD and related chemicals exert many of their toxicities , has been activated .",
            "output": [
                "Ah receptor"
            ]
        },
        {
            "id": "task1481-389c5b624e3842c99cfa60e4385d10c7",
            "input": " The analysis of the effects of eight signaling molecules in the TGFbeta , FGF , Hh , Wnt , and EGF families in tooth explant cultures revealed that the expression of edar was induced by activinbetaA , whereas Wnt6 induced ectodysplasin expression .",
            "output": [
                "EGF families"
            ]
        },
        {
            "id": "task1481-f726e869e1ba46f7a51e566be8e61643",
            "input": " Sequences within the UAS2 element of the ENO2 gene bound a second protein which corresponded to the ABFI ( autonomously replicating sequence - binding factor ) protein .",
            "output": [
                "ENO2 gene"
            ]
        },
        {
            "id": "task1481-8b09d62a4cb54ffabca47b2b4f5679ef",
            "input": " This action could be antagonized by aminophylline , a competitive antagonist on P1 purinoceptors .",
            "output": [
                "P1 purinoceptors"
            ]
        },
        {
            "id": "task1481-16903f9b38534a9d867392aaed2d1a37",
            "input": " We identified clones of Chlamydomonas genomic DNA that rescued the Ca ( 2 + ) - dependent axonemal microtubule severing defect of fa1 mutants .",
            "output": [
                "fa1 mutants"
            ]
        },
        {
            "id": "task1481-592c7b9bb3a14720ab46b823541128fa",
            "input": " Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses .",
            "output": [
                "CCR5 genes"
            ]
        },
        {
            "id": "task1481-79813426d668434aa4b30158ef5ace72",
            "input": " CYP51P1 is 96 . 5 % identical to the human CYP51 coding sequence and is not interrupted with introns but has six in - frame stop codons resulting from point mutations .",
            "output": [
                "human CYP51"
            ]
        },
        {
            "id": "task1481-67ff3fdef759401a97c048362549e31f",
            "input": " This complex was eliminated by mutation of either half - site , and it was supershifted by antibodies against chicken ovalbumin upstream promoter - transcription factor ( COUP - TF ) .",
            "output": [
                "COUP - TF"
            ]
        },
        {
            "id": "task1481-a959cb5daf0f4c298ad947679e059cea",
            "input": " In contrast , the sequences essential for the transcription of EFT1 were localized to the region between the start ATG and the stop codon of the VPS17 gene that terminates 267 nt upstream on the same strand .",
            "output": [
                "VPS17 gene"
            ]
        },
        {
            "id": "task1481-854710a779cf4ecfbee48a771e6d4e8d",
            "input": " The Tat protein coded by human immunodeficiency virus ( HIV ) is a strong activator of viral gene expression from the long terminal repeat ( LTR ) .",
            "output": [
                "Tat protein"
            ]
        },
        {
            "id": "task1481-bd3aafea2f204e4595d7e943182ed83c",
            "input": " Similar tissue - specific patterns are observed with a fusion between the caufliflower mosaic virus 35S RNA promotor and the GUS gene .",
            "output": [
                "GUS gene"
            ]
        },
        {
            "id": "task1481-28b4145d68d74ed5a065ebb25fd00b6c",
            "input": " Postheparin lipoprotein lipase , measured using fat emulsion as substrate , also was significantly greater in female rats compared with males .",
            "output": [
                "lipoprotein lipase"
            ]
        },
        {
            "id": "task1481-ae84473344a7419a946f642eeeba848a",
            "input": " Molecular cloning of cDNAs encoding alpha - subunits of guanine nucleotide - binding regulatory proteins ( G - proteins ) has revealed the existence of nine species of alpha - subunits .",
            "output": [
                "G - proteins"
            ]
        },
        {
            "id": "task1481-ab9fe89d89464dd1aa61a987d397c30d",
            "input": " Heterotrimeric guanine nucleotide - binding proteins ( G - proteins ) function as signal transducers for a variety of hormone - coupled enzyme and ion transport systems in eukaryotic cells .",
            "output": [
                "G - proteins"
            ]
        },
        {
            "id": "task1481-e232cca6374b44ec9965332210b694de",
            "input": " A DNA fragment that complements the uvs - 2 mutation was subcloned by monitoring its ability to transform the uvs - 2 mutant to MMS resistance .",
            "output": [
                "uvs - 2"
            ]
        },
        {
            "id": "task1481-9025c0df72974279a252a35cf9188b6c",
            "input": " These data may indicate redundancy between members of the NGFI - B / Nurr1 / Nor1 subfamily and could explain why no phenotypic disturbances have yet been found in mice in which the NGFI - B gene has been inactivated .",
            "output": [
                "NGFI - B"
            ]
        },
        {
            "id": "task1481-980632f08adb4525855a50660a821226",
            "input": " The N - terminal exon1 had no homology at the amino acid level with NGFI - B , the mammalian homologue .",
            "output": [
                "NGFI - B"
            ]
        },
        {
            "id": "task1481-524b5f332b764674bc38596b695f3e4e",
            "input": " The secondary end points included creatine kinase peak , ventricular fibrillation / tachycardia within the first 24 hours , death and congestive heart failure within the 30 - day follow - up , and 30 - day left ventricular ejection fraction .",
            "output": [
                "creatine kinase"
            ]
        },
        {
            "id": "task1481-8314538e404a4ba18e15ae3a05ec4529",
            "input": " To explore further the role of the carboxyl - terminal domain in determining the cell cycle function of CDC34 , we constructed and characterized genes encoding chimeric E2s incorporating sequences from CDC34 and the related but functionally distinct E2 RAD6 ( UBC2 ) .",
            "output": [
                "chimeric E2s"
            ]
        },
        {
            "id": "task1481-6342622540ac4303b6b13096dd5fc57c",
            "input": " The two complexes were detected with a similar activation kinetics upon IL - 4 stimulation .",
            "output": [
                "IL - 4"
            ]
        },
        {
            "id": "task1481-3829fe86bf824282a02b5287d87dbfe0",
            "input": " Analysis of 1 Mb of published sequence from the region of conserved synteny on human chromosome 5q31 - q33 identified 45 gene candidates , including 35 expressed genes in the human IL - 4 cytokine gene cluster .",
            "output": [
                "IL - 4"
            ]
        },
        {
            "id": "task1481-87cd2b60bcdf46c796e0390e091e4a5a",
            "input": " In this report , we identify Tyr319 as a functionally important phosphorylation site in the ZAP - 70 interdomain B region .",
            "output": [
                "ZAP - 70"
            ]
        },
        {
            "id": "task1481-bd5115dd5ec64715b78ca4c22e562a5c",
            "input": " Here we demonstrate that the T cell antigen receptor zeta - chain - associated ZAP - 70 kinase and T cell antigen receptor zeta - chain immunoreceptor tyrosine - based activation motifs are essential for the membrane recruitment of SOS and Vav .",
            "output": [
                "ZAP - 70"
            ]
        },
        {
            "id": "task1481-11e47fedc87446a9bf0e2ace71db2102",
            "input": " The preference for third base codon in Y position prolines is U for the alpha 2 ( VI ) collagen as it is for the human fibrillar collagen genes .",
            "output": [
                "alpha 2"
            ]
        },
        {
            "id": "task1481-bfa1dc04e5e84df28d008115af569a0f",
            "input": " Intrathecal injections of small volumes of the alpha 2 - adrenoceptor agonists , xylazine and clonidine , into the cervical region of the spinal cord of conscious unrestrained sheep produced a dose - dependent analgesia of the forelimbs as measured using a mechanical pressure device .",
            "output": [
                "alpha 2"
            ]
        },
        {
            "id": "task1481-e10a18e7f2ab4a03b847a87e66768bae",
            "input": " Cotransfection of a junB stimulated the basal activity of the alpha 2 ( I ) collagen promoter 93 - fold , respectively .",
            "output": [
                "alpha 2"
            ]
        },
        {
            "id": "task1481-0f3f79bd422b4f77b3a3a821168b2e5b",
            "input": " Growth factors promote cell survival through phosphorylation of Bad , resulting in its dissociation from Bcl - 2 and Bcl - x ( L ) and its association with 14 - 3 - 3tau .",
            "output": [
                "Bcl - 2"
            ]
        },
        {
            "id": "task1481-24990745e7a1404fa27ff2112fb945c9",
            "input": " Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13 . 3 , a region associated with the microphthalmia - cataract syndrome CATM and the alpha - thalassemia / mental retardation syndrome ATR - 16 .",
            "output": [
                "t complex"
            ]
        },
        {
            "id": "task1481-3d52e9fba07a48dba44d2e05f3f18ed1",
            "input": " Sequence analysis of AEBP2 cDNA revealed that it encodes a protein containing three Gli - Kruppel ( Cys2 - His2 ) - type zinc fingers .",
            "output": [
                "AEBP2 cDNA"
            ]
        },
        {
            "id": "task1481-ae017fedc1e8411a96ffebfb1279a8f0",
            "input": " Antiserum raised against rat liver S6 kinase specifically immunoprecipitates the purified 32P - labeled H4 hepatoma insulin - stimulated S6 kinase .",
            "output": [
                "S6 kinase"
            ]
        },
        {
            "id": "task1481-ae2b1c3123834bfb95f163d41b46ad3d",
            "input": " Northern blot analysis confirmed that ADAMTS - 1 was up - regulated in both metaphyseal ( 14 - to 35 - fold ) and diaphyseal ( 4 . 2 - fold ) bone 1 h after PTH - ( 1 - 38 ) injection and returned to control levels by 24 h .",
            "output": [
                "ADAMTS - 1"
            ]
        },
        {
            "id": "task1481-cd0e319b83824591bbed62473e12faf1",
            "input": " The derepressed expression of fixN was not observed in a purH mutant .",
            "output": [
                "purH mutant"
            ]
        },
        {
            "id": "task1481-19f76dd93180471d9bbf8c752fe1bf42",
            "input": " The library will thus be useful for the selection of cosmid clones which carry CDC genes from yeast by complementing first , with the vectorial yeast gene URA1 , the pyrimidine auxotrophy of most cdc - strains and then , with the respective CDC wild - type genes , of the temperature - sensitive mutant alleles .",
            "output": [
                "yeast gene URA1"
            ]
        },
        {
            "id": "task1481-c1e8d6c06e0e41af9216f77b523765d7",
            "input": " The RsmA - mutant , like its parent , produces N - ( 3 - oxohexanoyl ) - L - homoserine lactone ( HSL ) , a starvation / cell density - sensing signal required for extracellular enzyme production .",
            "output": [
                "RsmA - mutant"
            ]
        },
        {
            "id": "task1481-06ff469b303842ac857127e87817d619",
            "input": " The BRSV L gene is 6573 nt in length and the derived polypeptide has 2162 aa .",
            "output": [
                "BRSV L gene"
            ]
        },
        {
            "id": "task1481-4b6597cfb22641d2b81d563cdfb0e06a",
            "input": " Recombinant propeptides containing mutations of one of the three tryptophan residues were three orders of magnitude less effective as inhibitors of mature cathepsin S than the wild - type propeptide .",
            "output": [
                "mature cathepsin S"
            ]
        },
        {
            "id": "task1481-836b8ca72ca14baa85e75e356395812f",
            "input": " The human RIL gene : mapping to human chromosome 5q31 . 1 , genomic organization and alternative transcripts .",
            "output": [
                "RIL gene"
            ]
        },
        {
            "id": "task1481-d52f48aa54544023aa4e47ce62b7f01f",
            "input": " A novel serine kinase activated by rac1 / CDC42Hs - dependent autophosphorylation is related to PAK65 and STE20 .",
            "output": [
                "serine kinase"
            ]
        },
        {
            "id": "task1481-c02e5653c21049afb4e31e08d3f413ca",
            "input": " The lipopolysaccharide - binding protein is a secretory class 1 acute - phase protein whose gene is transcriptionally activated by APRF / STAT / 3 and other cytokine - inducible nuclear proteins .",
            "output": [
                "STAT / 3"
            ]
        },
        {
            "id": "task1481-5893cda2fae94d0db67363a9eb6d8a3d",
            "input": " In situ hybridization reveals strong signals for Zep mRNA in the cerebellum and olfactory bulb with moderate signals detected in the hippocampus and cortex .",
            "output": [
                "Zep mRNA"
            ]
        },
        {
            "id": "task1481-f5f9e5dc91b1450e8213c46e3d78b49a",
            "input": " To further investigate the role of PKR in transcriptional signaling , we expressed the wild type human PKR and a catalytically inactive dominant negative PKR mutant in the murine pre - B lymphoma 70Z / 3 cells .",
            "output": [
                "PKR mutant"
            ]
        },
        {
            "id": "task1481-23798e2cdb704614b61c7fc94f3f3815",
            "input": " All such polypeptides containing 263 or more residues derived from the C - terminus of P130gag - fps ( i . e . residues 920 - 1182 ) were enzymatically active as tyrosine kinases .",
            "output": [
                "tyrosine kinases"
            ]
        },
        {
            "id": "task1481-c95b7d608c844b5ba69f74faee1eb0c7",
            "input": " A child presumed to have the 21 - hydroxylase deficiency form of congenital adrenal hyperplasia was studied extensively as an infant .",
            "output": [
                "21 - hydroxylase"
            ]
        },
        {
            "id": "task1481-61c45b98debd49e9a6b40a24d50a2e4f",
            "input": " Viral protein U ( Vpu ) is a protein encoded by human immunodeficiency virus type 1 ( HIV - 1 ) that promotes the degradation of the virus receptor , CD4 , and enhances the release of virus particles from cells .",
            "output": [
                "Viral protein U"
            ]
        },
        {
            "id": "task1481-d88a3a92cfde47039e595d218bc7ceb5",
            "input": " Sucrose - specific signalling represses translation of the Arabidopsis ATB2 bZIP transcription factor gene .",
            "output": [
                "bZIP transcription factor"
            ]
        },
        {
            "id": "task1481-0c3fbaf5b7fc41c98e997f96c6d6fbd2",
            "input": " Mapping of the region in KAP - 1 required for HP1 interaction showed that amino acid substitutions which abolish HP1 binding in vitro reduce KAP - 1 mediated repression in vivo .",
            "output": [
                "KAP - 1"
            ]
        },
        {
            "id": "task1481-397d8c0d88324395839f26ffb3fa11f9",
            "input": " The activity of plasminogen activator has been measured in tissue sections with the aid of a modified Todd technique .",
            "output": [
                "plasminogen activator"
            ]
        },
        {
            "id": "task1481-945211cf58d34cf78bf76927d8952a0a",
            "input": " The predicted amino acid sequence contained all consensus regions for S - adenosyl methionine methyltransferases and presented 26 % identity with Saccharomyces cerevisiae DHHB - methyltransferase and 38 % identity with the rat protein , as well as with a bacterial ( Escherichia coli and Salmonella typhimurium ) methyltransferase encoded by the UBIG gene .",
            "output": [
                "UBIG gene"
            ]
        },
        {
            "id": "task1481-8cd41468738a476e8ee4f942d6ee3b99",
            "input": " Reduced risk of upper gastrointestinal ulcer complications with celecoxib , a novel COX - 2 inhibitor .",
            "output": [
                "COX - 2"
            ]
        },
        {
            "id": "task1481-96f8d88f445d4ac98fa7c0451c89e006",
            "input": " Recently , we reported that SMRT also directly associates with LAZ3 ( BCL - 6 ) , a POZ / Zn finger transcriptional repressor involvedin the pathogenesis of non - Hodgkin lymphomas .",
            "output": [
                "BCL - 6"
            ]
        },
        {
            "id": "task1481-5da129e678eb4a7cbf4782f27490eb6c",
            "input": " Immunological studies also failed to demonstrate any significant change except for a significant increase of natural killer ( NK ) cell activity after IFN - gamma infusion .",
            "output": [
                "IFN - gamma"
            ]
        },
        {
            "id": "task1481-98aeafcb5adf49d4912617dbfb2c4112",
            "input": " Mycobacterium tuberculosis inhibits IFN - gamma transcriptional responses without inhibiting activation of STAT1 .",
            "output": [
                "IFN - gamma"
            ]
        },
        {
            "id": "task1481-ec98ecaff2d245f5a5d52be1e37eea80",
            "input": " Cloning of the GATA - binding protein that regulates endothelin - 1 gene expression in endothelial cells .",
            "output": [
                "endothelin - 1"
            ]
        },
        {
            "id": "task1481-f04bd3ff2df44bdcb1e8c1a7e547c485",
            "input": " Coronary vasoconstriction caused by endothelin - 1 is enhanced by ischemia - reperfusion and by norepinephrine present in concentrations typically observed after neonatal cardiopulmonary bypass .",
            "output": [
                "endothelin - 1"
            ]
        },
        {
            "id": "task1481-34f34e5397f2471480a441bd82c3afc5",
            "input": " The first operon , orf1 - tolQRA , is iron regulated throughout growth , but iron - regulated expression of tolB and oprL fusions occurs only in late log phase .",
            "output": [
                "oprL fusions"
            ]
        },
        {
            "id": "task1481-65a1e22b55c147f0ac62eec8bc4a155f",
            "input": " Three distinct human HDACs are homologous to RPD3 , a yeast transcriptional regulator .",
            "output": [
                "human HDACs"
            ]
        },
        {
            "id": "task1481-9129c11b54754c7694527da8486f5a5c",
            "input": " The c - raf - 1 proto - oncogene is the cellular homologue of v - raf , the oncogene of the acutely transforming retrovirus 3611 - MSV .",
            "output": [
                "v - raf"
            ]
        },
        {
            "id": "task1481-c996773620824be98ab6f28ede0ed3cd",
            "input": " A decrease was also found of the levels of total cholesterol and LDL - cholesterol .",
            "output": [
                "LDL - cholesterol"
            ]
        },
        {
            "id": "task1481-83514c678b294301bb668637a8dd3ace",
            "input": " In contrast , vRel lacks a strong C - terminal gene activation function , since a LexA fusion protein containing C - terminal vRel sequences alone only weakly activated transcription .",
            "output": [
                "LexA fusion protein"
            ]
        },
        {
            "id": "task1481-dbfded3bd441444594936398d5e4ed93",
            "input": " These findings also demonstrate that unless excluded by other factors , the C proteins are likely to be located along the length of nascent transcripts .",
            "output": [
                "C proteins"
            ]
        },
        {
            "id": "task1481-513fd079e6424b5abedf0089f7b947fd",
            "input": " The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide - induced bronchoconstriction in patients with asthma .",
            "output": [
                "leukotriene receptor"
            ]
        },
        {
            "id": "task1481-a9c2d36b412841469711a6faccf28134",
            "input": " Transcription start sites of sal and salR genes were determined to lie 30 - and 24 - bp upstream of the respective initiation codons and separated from each other by 78 nucleotides .",
            "output": [
                "salR genes"
            ]
        },
        {
            "id": "task1481-fbfe409d321349959ecce6c56c31801f",
            "input": " ADR1 in extracts made from glucose - repressed and - derepressed cells bound UAS1 DNA with similar affinities despite having greatly different abilities to activate ADH2 gene expression in vivo .",
            "output": [
                "ADH2 gene"
            ]
        },
        {
            "id": "task1481-a76baefbb836475f8b871fa3dbdc1479",
            "input": " Scleraxis overexpression enhanced expression of the aggrecan gene , which is not normally expressed at high levels in these osteoblastic cells .",
            "output": [
                "aggrecan gene"
            ]
        },
        {
            "id": "task1481-3abae1cb9e414ace888a74d056fe55ac",
            "input": " Treatment of excessive bleeding after cardiopulmonary bypass was based on an algorithm using point - of - care testing with whole blood prothrombin time , activated partial thromboplastin time , heparinase activated clotting time , and platelet count .",
            "output": [
                "blood prothrombin"
            ]
        },
        {
            "id": "task1481-f98c8d551f0c4f0485d58c01525b0529",
            "input": " The generation of dorso - ventral polarity during Drosophila embryogenesis is regulated by the action of 12 maternally expressed gene products , the dorsal group .",
            "output": [
                "dorsal group"
            ]
        },
        {
            "id": "task1481-4f54ff15adaa44e4923fc3615fdc3d5a",
            "input": " gp170 is expressed at a level 30 to 50 % of the Env precursor gp130 .",
            "output": [
                "Env precursor"
            ]
        },
        {
            "id": "task1481-c92e14e161074aaa833be8c968bf286d",
            "input": " The NF1 family members and HNF4 interacted with overlapping sequences of the L - II element , wherein the 5 ' half - site was more critical for NF1 binding , and the 3 ' site was more important for HNF4 binding .",
            "output": [
                "NF1 family"
            ]
        },
        {
            "id": "task1481-35e1534cbb6b4f71b08cf4ba4582e901",
            "input": " Siglec - 9 is predicted to contain three extracellular immunoglobulin - like domains that comprise an N - terminal V - set domain and two C2 - set domains , a transmembrane region and a cytoplasmic tail containing two putative tyrosine - based signaling motifs .",
            "output": [
                "Siglec - 9"
            ]
        },
        {
            "id": "task1481-b3492fc35cb34d36b484a043b5655dce",
            "input": " Here , we analyzed the interaction of CYT - 18 with a small RNA ( P4 - P6 RNA ) corresponding to the isolated P4 - P6 domain of the N . crassa mitochondrial large subunit ribosomal RNA intron .",
            "output": [
                "CYT - 18"
            ]
        },
        {
            "id": "task1481-3b680adfe3be44f792712b5501d4cca7",
            "input": " The gene encoding the Neisseria lactamica III DNA methyltransferase ( M . NlaIII ) which recognizes the sequence CATG has been cloned and expressed in Escherichia coli .",
            "output": [
                "M . NlaIII"
            ]
        },
        {
            "id": "task1481-90b39cff538d4e1ca6a4b5911446bdc6",
            "input": " Plasma insulin responses to glucose in femoral , hepatic , and pancreatic veins in dogs .",
            "output": [
                "Plasma insulin"
            ]
        },
        {
            "id": "task1481-6c3b6c07cacf442084c3b6c45d85ba87",
            "input": " TOM1 encodes a member of the hect - domain - containing E3 ubiquitin - protein ligase family that is required for growth at elevated temperatures .",
            "output": [
                "hect - domain"
            ]
        },
        {
            "id": "task1481-8f5db90e24664b8a850275c0885170be",
            "input": " Site - directed mutagenesis of the conserved cysteine residue ( tom1C3235A ) in the hect - domain , supposed to be necessary for thioester - bond formation with ubiquitin , abolished the gene function .",
            "output": [
                "hect - domain"
            ]
        },
        {
            "id": "task1481-bbbdca7f9c9f4708ba0289752d03dbfd",
            "input": " Multiple attempts aimed at disruption of the chromosomal fabG gene were unsuccessful .",
            "output": [
                "chromosomal fabG gene"
            ]
        },
        {
            "id": "task1481-0f9f367a01444b188d4d7f9d540366c9",
            "input": " Furthermore , the GC - rich sequences could confer Sp1 - dependent transactivation to a heterologous prolactin minimal promoter .",
            "output": [
                "prolactin minimal promoter"
            ]
        },
        {
            "id": "task1481-94649ad0e48f48d5acfe10052ff77aeb",
            "input": " To address this question with respect to skeletal muscle , we have examined the effects of the Providence mutation in cultured muscle cells , after adoptive gene transfer to adult mice , and in two infants homozygous for spectrin Providence .",
            "output": [
                "spectrin Providence"
            ]
        },
        {
            "id": "task1481-5a4e47cf9ec24c0592506ce70dcb4612",
            "input": " A gene ( FMR - 1 ) was identified within a four cosmid contig of YAC DNA that expresses a 4 . 8 kb message in human brain .",
            "output": [
                "FMR - 1"
            ]
        },
        {
            "id": "task1481-80dfbc2bef8c4885ae41473faf41df04",
            "input": " When expressed in Escherichia coli , SH - PTP2 displays tyrosine - specific phosphatase activity .",
            "output": [
                "SH - PTP2"
            ]
        },
        {
            "id": "task1481-af985f2815a54231bba84a2e683a9fb5",
            "input": " C . glabrata cells containing the CBF1 gene under the influence of a shutdown promoter ( tetO - ScHOP ) arrested their growth after 5 h of cultivation in the presence of the reactive drug doxycycline .",
            "output": [
                "CBF1 gene"
            ]
        },
        {
            "id": "task1481-62890300419f4e87848fee32bad3e517",
            "input": " GAGA factor is known to remodel the chromatin structure in concert with nucleosome - remodeling factor NURF in a Drosophila embryonic S150 extract .",
            "output": [
                "GAGA factor"
            ]
        },
        {
            "id": "task1481-cf330504112048b295076bc9bd95b6f4",
            "input": " Several of the drugs used in the management of MAC have been associated with significant drug interactions involving the cytochrome P450 ( CYP ) enzyme system .",
            "output": [
                "cytochrome P450"
            ]
        },
        {
            "id": "task1481-b944661a8743440f80283315550e808c",
            "input": " These include urinalysis , chest X - P , ECG , hematological examinations ( RBC , WBC , Ht , Hb , PLT and ESR ) and biochemical tests ( AST , ALT , ALP , gamma GTP , LDH , CPK , Chol , T - Bil , TP , Alb , TG , BUN , Cr , Glu , Na , K , Ca , P and CRP ) .",
            "output": [
                "gamma GTP"
            ]
        },
        {
            "id": "task1481-2553fcc417cf420280b0d72ebe07abc4",
            "input": " Transcriptional activation of the proopiomelanocortin gene by cyclic AMP - responsive element binding protein .",
            "output": [
                "proopiomelanocortin gene"
            ]
        },
        {
            "id": "task1481-6c040bf4caae4128ab30f2ec3d88b96f",
            "input": " Mutation of the HNF3 element significantly reduced promoter activity in HepG2 cells , whereas this element in isolation conferred HNF3beta responsiveness to a heterologous promoter .",
            "output": [
                "HNF3 element"
            ]
        },
        {
            "id": "task1481-64694838772f44b2974c4a2a097c4a18",
            "input": " It is hypothesized this occurs through antagonism of PML / RAR alpha actions in these leukemic cells .",
            "output": [
                "RAR alpha"
            ]
        },
        {
            "id": "task1481-d2d78f4f165c4bbe9b6232fb6002c8ae",
            "input": " Using the conflict drinking test as a model , we studied in rats the effect of the nonselective beta - adrenoceptor blockers pindolol and cyanopindolol which bind to 5 - HT1A and 5 - HT1B receptors , and of the selective beta 1 - and beta 2 - adrenoceptor antagonists betaxolol and ICI 118 , 551 , respectively , which have a negligible affinity for 5 - HT receptors .",
            "output": [
                "beta - adrenoceptor"
            ]
        },
        {
            "id": "task1481-0861078d613b44a5ae68becadc9fdd1f",
            "input": " It is an untested argument that conventional beta - adrenoceptor antagonists possess unwanted metabolic effects that may counter some of their potential cardiac benefits .",
            "output": [
                "beta - adrenoceptor"
            ]
        },
        {
            "id": "task1481-d526700311b14f4d9bbfcd45bc691803",
            "input": " The 5 ' ends of the P and O gene mRNAs are separated by 109 nucleotide pairs in the DNA template .",
            "output": [
                "O gene mRNAs"
            ]
        },
        {
            "id": "task1481-12c3ee475c664dd7b4aa3c33563b43e1",
            "input": " Drosophila melanogaster casein kinase II ( DmCKII ) is composed of catalytic ( alpha ) and regulatory ( beta ) subunits associated as an alpha2beta2 heterotetramer .",
            "output": [
                "casein kinase II"
            ]
        },
        {
            "id": "task1481-97d76ef5c6a447aab4a47d3b99143310",
            "input": " We now describe a HepG2 cell casein kinase II beta subunit cDNA of 2 . 57 kb containing 96 bases of 5 ' untranslated sequence , 645 bases of open reading frame , and 1832 bases of 3 ' untranslated sequence with two polyadenylation consensus signal sequences and two poly ( A ) stretches .",
            "output": [
                "casein kinase II"
            ]
        },
        {
            "id": "task1481-b39e64fbc89a499dbd4bfb01e7a3687c",
            "input": " A genomic clone of the chicken osteopontin - encoding gene ( opn ) was isolated and found to be organized as follows : an untranslated 5 ' exon ; a signal peptide ; a recognition sequence for phosphorylation by casein kinase II ; a domain containing a possible O - linkage site for glycosylation ; a second casein kinase II phosphorylation site ; an exon containing three functional regions , the poly - Asp sequence of seven consecutive Asp residues , the RGD integrin recognition site and a potential N - linkage site for glycosylation ; and a large C - terminal exon which also contains a potential N - linkage site for glycosylation .",
            "output": [
                "casein kinase II"
            ]
        },
        {
            "id": "task1481-83e21e844341405b80c9b5168ba2932b",
            "input": " Vertebrate U6 small nuclear RNA ( snRNA ) loci exemplify a novel class of polymerase III - transcribed genes that lack an intragenic control region ( ICR ) .",
            "output": [
                "polymerase III"
            ]
        },
        {
            "id": "task1481-f793c447f19145a9be1684eda03512d9",
            "input": " A deletion analysis of the FAS1 promoter lacking the previously characterized inositol / choline - responsive - element motif defined a region ( nucleotides - 760 to - 850 ) responsible for most of the remaining activation potency .",
            "output": [
                "FAS1 promoter"
            ]
        },
        {
            "id": "task1481-268f148fa6a44e2ba753acf6f778a29b",
            "input": " Upstream tissue inhibitor of metalloproteinases - 1 ( TIMP - 1 ) element - 1 , a novel and essential regulatory DNA motif in the human TIMP - 1 gene promoter , directly interacts with a 30 - kDa nuclear protein .",
            "output": [
                "TIMP - 1"
            ]
        },
        {
            "id": "task1481-8f6b163440f34dd59f210bfb377ea28c",
            "input": " Hepatitis B immune globulins and HIV antibodies .",
            "output": [
                "HIV antibodies"
            ]
        },
        {
            "id": "task1481-9365c89c09a8494c99e5e668c0f38d54",
            "input": " These results demonstrate that GGTase - I inhibitors arrest cells in G0 / G1 and induce accumulation of p21WAF in a p53 - independent manner and that FTase inhibitors can interfere with cell cycle events by a mechanism that involves neither p21WAF nor p27KIP .",
            "output": [
                "GGTase - I"
            ]
        },
        {
            "id": "task1481-a62e2cd1c80e43619607eeee4ffa3d34",
            "input": " The CHED protein includes the consensus ATP binding and phosphorylation domains characteristic of kinases , displays 34 - 42 % identically aligned amino acid residues with other cdc2 - related kinases , and is considerably longer at its amino and carboxyl termini .",
            "output": [
                "CHED protein"
            ]
        },
        {
            "id": "task1481-782abf73817a46189c531af83df0cd9c",
            "input": " Translation of mok is tightly regulated by Sok RNA , and Sok RNA thus regulates hok translation indirectly through mok .",
            "output": [
                "Sok RNA"
            ]
        },
        {
            "id": "task1481-f5b255018cb641ed981608f869a2df34",
            "input": " Cytokine inducibility of VCAM1 in endothelial cells utilizes the interaction of heterodimeric p50 / p65 proteins with IRF - 1 .",
            "output": [
                "IRF - 1"
            ]
        },
        {
            "id": "task1481-9c8e49c28d31403b8f57c60ff6396399",
            "input": " First , mutations in the IFNgamma - activated sequence ( GAS ) , either multimerized or in the context of the 1 . 7 - kb IRF - 1 promoter , failed to mediate a PRL response , showing that the IRF - 1 GAS is a target of PRL signaling .",
            "output": [
                "IRF - 1"
            ]
        },
        {
            "id": "task1481-4df632b5773947ebbad35bbe41aa0f13",
            "input": " However , ADAR1 and the related deaminase ADAR2 showed significant expression in all regions of the brain examined , including cortex , hippocampus , olfactory bulb , and striatum , where the 5 - HT2CR pre - mRNA was extensively edited .",
            "output": [
                "deaminase ADAR2"
            ]
        },
        {
            "id": "task1481-922e18e83c424ed996d047268784f3dc",
            "input": " This C - terminal domain contains several YxxI / L motifs reminiscent of LMP2A and a putative TRAF binding site as in LMP1 .",
            "output": [
                "TRAF binding site"
            ]
        },
        {
            "id": "task1481-54dfbb31158c4e219ead20b3f93ea7d7",
            "input": " BACKGROUND : Recent iterative methods for sequence alignment have indicated that the 380 kDa motor unit of dynein belongs to the AAA class of chaperone - like ATPases .",
            "output": [
                "AAA class"
            ]
        },
        {
            "id": "task1481-840b32a696fc48b4a86e132ee141e2e4",
            "input": " Chromaffin cells transfected with a plasmid with the entire coding sequence of c - Rabphilin3a inserted in the antisense orientation inhibited secretion of co - expressed GH by approximately 30 % .",
            "output": [
                "c - Rabphilin3a"
            ]
        },
        {
            "id": "task1481-73a662b8511a4e93a9aaaadcceaab418",
            "input": " Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults .",
            "output": [
                "fumonisin B1"
            ]
        },
        {
            "id": "task1481-ab90711157ea4636b69bf0e502d5cc9f",
            "input": " Four of these fibroblast clones were infected with a retrovirus containing the cDNA encoding myoD and a puromycin selection marker .",
            "output": [
                "cDNA encoding myoD"
            ]
        },
        {
            "id": "task1481-2a1ac1249fa04e57a5980e2bcc54aa26",
            "input": " However , PC12 cell clones which expressed p33rsu - 1 at an increased level in a regulatable fashion in response to dexamethasone were isolated .",
            "output": [
                "p33rsu - 1"
            ]
        },
        {
            "id": "task1481-1a362fb59cf04b84a98c299688789984",
            "input": " B and C1 fusions with yeast GAL4 DNA - binding and transcriptional activation domains were also found to interact when synthesized and assayed in yeast .",
            "output": [
                "C1 fusions"
            ]
        },
        {
            "id": "task1481-33c275b2078f49b084ebe48cbc096cd5",
            "input": " Using transgenic lines a detailed analysis of the Hoxa - 7 enhancer - directed expression during embryogenesis was performed .",
            "output": [
                "Hoxa - 7"
            ]
        },
        {
            "id": "task1481-de6a2bce964c4d4fbac463741d818d5f",
            "input": " A Brassica cDNA clone encoding a bifunctional hydroxymethylpyrimidine kinase / thiamin - phosphate pyrophosphorylase involved in thiamin biosynthesis .",
            "output": [
                "hydroxymethylpyrimidine kinase"
            ]
        },
        {
            "id": "task1481-5c25c3abc36b473faa463288b24edc76",
            "input": " Induction of interferon - alpha ( IFNalpha ) gene expression in virus - infected cells requires phosphorylation - induced activation of the transcription factors IRF3 and IRF7 .",
            "output": [
                "interferon - alpha"
            ]
        },
        {
            "id": "task1481-2e5e9464c2af4c03a7cdacaa7d3a9221",
            "input": " Since 1985 the combination of chlorambucil ( 10 mg daily , initially for six weeks , then alternating fortnights for 12 weeks ) and interferon - alpha 2b ( Schering - Plough ; 2 x 10 ( 6 ) U / m2 three times weekly by subcutaneous injection for 18 weeks ) has been compared in a randomised trial with chlorambucil alone in previously untreated patients with stage III or IV follicular lymphoma .",
            "output": [
                "interferon - alpha"
            ]
        },
        {
            "id": "task1481-12c52a1381244cd2a0192bb11e3805e4",
            "input": " This paper describes a longitudinal study in which clinical parameters and aspartate aminotransferase ( AST ) in gingival crevicular fluid ( GCF ) were monitored bimonthly over a 6 - 12 months period in 970 sites from 7 treated periodontitis patients .",
            "output": [
                "aspartate aminotransferase"
            ]
        },
        {
            "id": "task1481-5fd2e26a419644509c55ed9e5bee17a5",
            "input": " Thus , the mutants are deficient in production of the O - antigen polymerase and were termed rfc mutants .",
            "output": [
                "rfc mutants"
            ]
        },
        {
            "id": "task1481-e4f6cd44cc0a45a384a6f5c27243566c",
            "input": " Competition and methylation interference assays showed that the binding site for the novel factor was limited to nucleotides in the 3 ' half of the kappa B site .",
            "output": [
                "kappa B site"
            ]
        },
        {
            "id": "task1481-0e74840362ef4fccb5b3bb5a2ea3fa64",
            "input": " Tax was demonstrated to interact directly with CREB1 but not with other bZIP proteins , including CREB2 and Jun .",
            "output": [
                "bZIP proteins"
            ]
        },
        {
            "id": "task1481-46ab866f83dc4ffbbfc9db0a65507708",
            "input": " Overexpression of eIF4E transforms cells , and mutations in eIF4E arrest cells in G , in cdc33 mutants .",
            "output": [
                "cdc33 mutants"
            ]
        },
        {
            "id": "task1481-1f647714969e46c6a114a5035565110f",
            "input": " Plasma enteroglucagon was measured before and during three hours after a standard meal in 21 untreated adult patients with suspected coeliac disease who all had villous atrophy of the small intestinal mucosa and malabsorption , and in nine control subjects .",
            "output": [
                "Plasma enteroglucagon"
            ]
        },
        {
            "id": "task1481-8da3e5457d53453ab5e146a697fb1b11",
            "input": " Members of the steroid / hormone nuclear receptor superfamily regulate target gene transcription via recognition and association with specific cis - acting sequences of DNA , called hormone response elements ( HREs ) .",
            "output": [
                "nuclear receptor superfamily"
            ]
        },
        {
            "id": "task1481-aee706f8515d4505a14ec00897214114",
            "input": " The human Fc gamma receptor gene Fc gamma RIIA is expressed in platelets , neutrophils , monocytes and macrophages .",
            "output": [
                "Fc gamma RIIA"
            ]
        },
        {
            "id": "task1481-53216dd0d16f4c1b9eebb555b84f185e",
            "input": " We also show that the products of both the GIY - YIG ORF and the non - canonical LAGLI - DADG - GIY - YIG ORF , which is generated by its integration , have endonuclease activities which recognize and cut the insertion site of the optional sequence .",
            "output": [
                "GIY - YIG"
            ]
        },
        {
            "id": "task1481-388a6d32a1db495799387f19b9ea3cc7",
            "input": " Hetero - oligomerization of Smad4 with the pathway - restricted SMAD proteins is essential for Smad4 - mediated transcription .",
            "output": [
                "SMAD proteins"
            ]
        },
        {
            "id": "task1481-f3d5bcf2ebb349e48df3f18e16fe22a9",
            "input": " CRKL , an SH2 - SH3 - SH3 adapter protein , is one of the major tyrosine phosphoproteins detected in primary leukemic neutrophils from patients with CML .",
            "output": [
                "tyrosine phosphoproteins"
            ]
        },
        {
            "id": "task1481-be482bf955ed4365b4da0038acdabf01",
            "input": " Both flavoproteins are active as AhpC reductases and mediate electron transfer , resulting in the NADH - dependent reduction of hydrogen peroxide and cumene hydroperoxide .",
            "output": [
                "AhpC reductases"
            ]
        },
        {
            "id": "task1481-aef923cd144e4bf1accff5867199d6c7",
            "input": " Developmental slot blots demonstrate that mRNAs corresponding to the three LHM cDNAs are transcribed from prophase of meiosis I to the uninucleate microspore stage , while Northern analysis reveals these tapetally expressed cDNAs to correspond with transcripts of some 500 bp .",
            "output": [
                "LHM cDNAs"
            ]
        },
        {
            "id": "task1481-ed9d801301d8470384b2ce5cdaf20f43",
            "input": " PCC 6803 mutant impaired in cytochrome c maturation .",
            "output": [
                "cytochrome c"
            ]
        },
        {
            "id": "task1481-884ddb07a34941bd9b0c5ad4b46e8b23",
            "input": " Studies on the reaction of cytochrome c with corticosteroids .",
            "output": [
                "cytochrome c"
            ]
        },
        {
            "id": "task1481-c268bc91dcc643e9ae5574ffb6eda4c4",
            "input": " In the present study we use a tnaC - UGA - ' lacZ construct lacking the tnaC - tnaA spacer region to analyze the effect of TnaC synthesis on the behavior of the ribosome that translates tnaC .",
            "output": [
                "' lacZ"
            ]
        },
        {
            "id": "task1481-7b39583942a34a07b7334435e2aac2e2",
            "input": " This study demonstrates a novel link between alterations in platelet - derived growth factor ( PDGF ) regulation of ornithine decarboxylase ( ODC ) expression during malignant conversion .",
            "output": [
                "ornithine decarboxylase"
            ]
        },
        {
            "id": "task1481-768003b6e36549fda5ed07108227305d",
            "input": " ( i ) p60 bound fast - migrating , underprocessed wild - type ICP22 and ICP22 lacking the carboxyl - terminal 24 amino acids but not ICP22 lacking the carboxyl - terminal 40 amino acids , whereas the previously identified cellular protein p78 ( R .",
            "output": [
                "cellular protein p78"
            ]
        },
        {
            "id": "task1481-b278c8e674a849f190c578a315828b5e",
            "input": " Our results suggest a dose - dependent activity of lysine vasopressin on the EEG , which might be similar to that observed in animal and man after administration of nicotine .",
            "output": [
                "lysine vasopressin"
            ]
        },
        {
            "id": "task1481-b3d6236428f84831854887a6e7ec6f1d",
            "input": " By screening a human testis cDNA library with a probe containing the mouse PEA3 ETS domain , we isolated a 2 . 2 kb clone containing a 510 AA open reading frame .",
            "output": [
                "mouse PEA3"
            ]
        },
        {
            "id": "task1481-0970e2869e9d461ca65a3bc4b2606615",
            "input": " After inhibition of monoamine oxidase with pargyline ( 10 mg / kg . i . v . ) , the effects of tyramine ( 1000 micrograms ) injected into the hepatic artery were potentiated .",
            "output": [
                "monoamine oxidase"
            ]
        },
        {
            "id": "task1481-00bd9a9133a049398f0fc0682a36fbe5",
            "input": " The inhibition of monoamine oxidase ( MAO ) by tranylcypromine was studied in 6 healthy volunteers given increasing doses of 10 , 15 , 20 and 25 mg / day over a 4 - week period .",
            "output": [
                "monoamine oxidase"
            ]
        },
        {
            "id": "task1481-45ef336b3f29435aa49b02fccce16b55",
            "input": " Nitroglycerin ( glyceryl trinitrate ) as a monoamine oxidase inhibitor .",
            "output": [
                "monoamine oxidase"
            ]
        },
        {
            "id": "task1481-3e5b9c7f1f314568b28a6780f80c46fd",
            "input": " Toxicity of benzoyl chloride ( 2 , 4 , 6 - trichlorophenyl ) hydrazone ( Banamite ) and potential metabolites to twospotted spider mites and potency as inhibitors of rat liver monoamine oxidase .",
            "output": [
                "monoamine oxidase"
            ]
        },
        {
            "id": "task1481-7381bcdd83e342738d0b0a91e68a895f",
            "input": " This results in a decreased secretion of immunoglobulin A , and , consequently , a decreased resistance against infections .",
            "output": [
                "immunoglobulin A"
            ]
        },
        {
            "id": "task1481-c8652ce6f8524f8e93b0348af40fe5c5",
            "input": " The proteins encoded by these genes , called GF14 proteins , participate in protein / DNA complexes and show more than 60 % identity with a highly conserved , widely distributed protein family , collectively referred to as 14 - 3 - 3 proteins .",
            "output": [
                "GF14 proteins"
            ]
        },
        {
            "id": "task1481-4ed997e8695b499eaa3bb8b409d6aeb0",
            "input": " Despite their high degree of sequence similarity , all five RFC genes are essential for cell proliferation in S . cerevisiae .",
            "output": [
                "RFC genes"
            ]
        },
        {
            "id": "task1481-21598b619aef41aa8efdb0f3b96a2a1f",
            "input": " Electrophoretic mobility - shift assays between viral RNA and BMV CP peptides with either proline or alanine substitutions revealed that the interaction is nonspecific .",
            "output": [
                "BMV CP peptides"
            ]
        },
        {
            "id": "task1481-efb73d69c6a74f4c87dff485d011bad8",
            "input": " The longest cDNA insert identified was 2 . 2 kb and encoded the entire 462 - amino acid open reading frame of rat CgA including an 18 - amino acid hydrophobic signal peptide .",
            "output": [
                "rat CgA"
            ]
        },
        {
            "id": "task1481-cfee166ff2994716a9625e0d6c3774b6",
            "input": " Primer extension analysis and subcloning of the virJ - phoA fusion indicate that the acetosyringone - inducible promoter lies directly upstream of the virJ structural gene .",
            "output": [
                "virJ structural gene"
            ]
        },
        {
            "id": "task1481-8b2475366c2f42379cf72d9c37927715",
            "input": " Patients in the mucinous cyst group had significantly lower CA 125 cystic fluid levels compared with women with endometriomas and dermoids ( P & lt ; 0 . 05 ) .",
            "output": [
                "CA 125"
            ]
        },
        {
            "id": "task1481-7efa5a7c711d4328b19b2ffccde7a95a",
            "input": " We report on a case of a 43 - old - male with a bronchogenic cyst in the distal esophagus , which was misdiagnosed as a malignant esophageal tumor based on preoperative imaging and high levels of the tumor markers CA 19 - 9 and CA 125 .",
            "output": [
                "CA 125"
            ]
        },
        {
            "id": "task1481-382e1a94b319420f90710e97fa7770ff",
            "input": " The enzyme ACC oxidase catalyses the last step of ethylene biosynthesis in plants , converting 1 - aminocyclopropane - 1 - carboxylic acid ( ACC ) to ethylene .",
            "output": [
                "enzyme ACC oxidase"
            ]
        },
        {
            "id": "task1481-ccbcbabbfda34e9b96a57100536517b9",
            "input": " Protein kinase C transiently activated heteromeric N - methyl - D - aspartate receptor channels independent of the phosphorylatable C - terminal splice domain and of consensus phosphorylation sites .",
            "output": [
                "Protein kinase C"
            ]
        },
        {
            "id": "task1481-5aedd026a12544de9c41b745c13c5748",
            "input": " Protein kinase C ( PKC ) activation after treatment of human neuroblastoma SK - N - BE ( 2 ) C cells with phorbol 12 - myristate 13 - acetate ( PMA ) was found to enhance transcription of the human dopamine beta - hydroxylase ( DBH ) in those cells .",
            "output": [
                "Protein kinase C"
            ]
        },
        {
            "id": "task1481-e27ed1344d6e48589a23914fd42216f2",
            "input": " Highly significant similarities were detected between the N - terminal region of P30 and those of GENA [ the product of another unidentified gene ( geneA ) located upstream of the aceEF - lpd operon ] , and GNTR ( a putative transcriptional repressor of the gluconate operon of Bacillus subtilis ) .",
            "output": [
                "gluconate operon"
            ]
        },
        {
            "id": "task1481-347f97a88998484f8b6b4da362ff325e",
            "input": " Like the DMA , but unlike all other mammalian class II A genes , the zebrafish gene codes for two cysteine residues which might potentially be involved in the formation of a disulfide bond in the alpha 1 domain .",
            "output": [
                "alpha 1"
            ]
        },
        {
            "id": "task1481-75a72a10bba44c3eb899c018fae2e003",
            "input": " Reactive mesothelial cells , usually seen as exfoliated cells , were consistently strongly positive for alpha 1 - antichymotrypsin and more variably for alpha 1 - antitrypsin and lysozyme .",
            "output": [
                "alpha 1"
            ]
        },
        {
            "id": "task1481-7d0812b343474e46a488b1a40720d348",
            "input": " Following replicate control measurements , test ramps were repeated in the presence of sodium nitroprusside ( 1 microM ) and phentolamine ( 1 microM ) to eliminate potential smooth muscle and alpha 1 - adrenoceptor effects , respectively .",
            "output": [
                "alpha 1"
            ]
        },
        {
            "id": "task1481-8700820b013b417e9addb8bf5a17028b",
            "input": " The unusual properties of TRAC activity and its relationship , if any , with the enigmatic Ku protein , are discussed .",
            "output": [
                "Ku protein"
            ]
        },
        {
            "id": "task1481-ce6ea7299a7f46d0bf8c363863689248",
            "input": " The pattern of net RNA expression in adult mouse tissues is different .",
            "output": [
                "net RNA"
            ]
        },
        {
            "id": "task1481-3fd15212c0da4f4ea8aa2a03c62d9702",
            "input": " The induction by dexamethasone of rat liver CYP3A1 differs from classical glucocorticoid gene regulation in part because both glucocorticoids and antiglucocorticoids such as pregnenolone 16 alpha - carbonitrile ( PCN ) induce CYP3A1 through transcriptional gene activation .",
            "output": [
                "rat liver CYP3A1"
            ]
        },
        {
            "id": "task1481-9d934fb66a744616ac308ef2101f092c",
            "input": " Human PDNP3 is expressed in glioma cells , prostate , and uterus , but not in the alimentary tract .",
            "output": [
                "Human PDNP3"
            ]
        },
        {
            "id": "task1481-4dc7d2d9b5a64aabb37448926f3fe827",
            "input": " The transcriptional start site , identified by primer extension and S1 nuclease assay , is 34 nt upstream of the translation initiation codon .",
            "output": [
                "S1 nuclease"
            ]
        },
        {
            "id": "task1481-cf3eef4a9a4d495ca764bd5de21963ef",
            "input": " S1 nuclease analysis of the RNA from a number of QT6 - LD clones gave similar results , indicating that the LD population was composed of viruses with similar but not identical deletion endpoints .",
            "output": [
                "S1 nuclease"
            ]
        },
        {
            "id": "task1481-463c1b81d8cf44ef94a0f78835d1200b",
            "input": " S1 nuclease protection mapping and primer extension analysis allowed us to propose that the A residue located 19 bp upstream from the translation initiation codon is the site of transcription initiation .",
            "output": [
                "S1 nuclease"
            ]
        },
        {
            "id": "task1481-b945c7eac9064606952785450296df39",
            "input": " The strategy uses RNA ligase to add DNA oligonucleotide priming sites to the RNA for subsequent reverse transcription and PCR ( RNA ligase , reverse transcription - PCR , or RL / RT / PCR ) .",
            "output": [
                "RNA ligase"
            ]
        },
        {
            "id": "task1481-30fe1eebd10c424f91dc7924f8032e52",
            "input": " Plasma hemopexin homeostasis during the acute phase response .",
            "output": [
                "Plasma hemopexin"
            ]
        },
        {
            "id": "task1481-852f1336a3a147a8a6f9eecc9e65e320",
            "input": " CONCLUSIONS : These results suggest that , by interacting with cellular transcription factors and cofactors , vIRF - 2 may modulate the expression of the early inflammatory genes and potentially deregulate the immune system .",
            "output": [
                "vIRF - 2"
            ]
        },
        {
            "id": "task1481-5795075afac14c2c94a3ecca08c3f28e",
            "input": " RESULTS : Although low levels of vIRF - 2 mRNAs can be detected in the HHV - 8 - positive BCBL - 1 tumor cell line , 12 - 0 - tetradecanoylphorbol - 13 - acetate ( TPA ) treatment does not stimulate expression of vIRF - 2 gene together with primary lytic cycle genes .",
            "output": [
                "vIRF - 2"
            ]
        },
        {
            "id": "task1481-5f2112cb8a4d488bbe684c96d8f4ebee",
            "input": " These data suggested that mutant PS1 may cause disease as a result of reduction in PS1 function .",
            "output": [
                "mutant PS1"
            ]
        },
        {
            "id": "task1481-cd3034ec010a4ba1bd9f852698e5acef",
            "input": " The deduced amino acid sequence of this open reading frame is significantly homologous to the HSV 1 UL49 . 5 gene product , and as with UL49 . 5 , it contains a potential signal sequence and transmembrane domain characteristic of membrane - associated proteins .",
            "output": [
                "UL49 . 5"
            ]
        },
        {
            "id": "task1481-f25b509d56934c938021f1b3c66426d6",
            "input": " The combination of ICP47 and US11 rendered fibroblasts negative for surface class I MHC and allowed a class I MHC - low population of T cells to be sorted by flow cytometry .",
            "output": [
                "class I MHC"
            ]
        },
        {
            "id": "task1481-982a7758da664f398ffb4470c96c3e7f",
            "input": " Alterations in TCR - MHC contacts subsequent to cross - recognition of class I MHC and singly substituted peptide variants .",
            "output": [
                "class I MHC"
            ]
        },
        {
            "id": "task1481-f4e04e8d32c24f2bbb57d4609a07d10e",
            "input": " Antisense oligonucleotides complementary to the 5 ' end of PKC - zeta mRNA sequences significantly reduced the collagen lattice - stimulated alpha2 and MMP - 1 mRNA levels .",
            "output": [
                "MMP - 1"
            ]
        },
        {
            "id": "task1481-dd9e278462b04e619b853b80966586b8",
            "input": " The myb proto oncogene product ( c - Myb ) is a transcriptional regulator and its expression and function are tightly linked to the cellular entry into S phase and DNA synthesis .",
            "output": [
                "c - Myb"
            ]
        },
        {
            "id": "task1481-09d69f0baa7f4681b3b5b75fe5df7006",
            "input": " From this comparison of aa sequences , the ATPK7 protein is considered to be a member of a novel subfamily of Ser / Thr PKs in plants .",
            "output": [
                "ATPK7 protein"
            ]
        },
        {
            "id": "task1481-6818341ebf154493932e01e449bd89a3",
            "input": " Thus , BCR ligation initiates a PI 3 - kinase / Akt / GSK - 3 signaling pathway .",
            "output": [
                "GSK - 3"
            ]
        },
        {
            "id": "task1481-7f3d0b52428147aebefc70faf5249b67",
            "input": " The vaccine was highly immunogenic , since 111 of 113 patients ( 98 % ) produced anti - HBs ( 10 mIU / ml or more ) .",
            "output": [
                "anti - HBs"
            ]
        },
        {
            "id": "task1481-fc1fb779654946a68c438fc28da235c4",
            "input": " The results of the transient - transfection assay showed that the Sp1 binding element located in the core region ( positions - - 64 to + 1 ) of the alpha2 - integrin promoter plays an essential role in the alpha2 - integrin promoter activity and its downregulation by Erb - B2 .",
            "output": [
                "Sp1 binding element"
            ]
        },
        {
            "id": "task1481-2a9e6de03d4f4543b95d6fd6b6be61ea",
            "input": " IL - 6 was detected in the urine of 52 % of children with pyelonephritis compared with 15 % of other children ( P < 0 . 001 ) .",
            "output": [
                "IL - 6"
            ]
        },
        {
            "id": "task1481-586bddaa39d64e92a36a71cd83c7a943",
            "input": " CONCLUSIONS : These results suggest that histamine - 2 receptor activation mechanisms may not be involved in postoperative IL - 6 synthesis .",
            "output": [
                "IL - 6"
            ]
        },
        {
            "id": "task1481-f7c1e2a5e9a446d18a2d561ea0bcd922",
            "input": " Previous studies have shown that the IME1 gene is required for sporulation and the expression of meiosis specific genes in Saccharomyces cerevisiae .",
            "output": [
                "IME1 gene"
            ]
        },
        {
            "id": "task1481-fcfced31e3cf43539d000fee72231e7c",
            "input": " Recently , we and other laboratories have identified a family of caveolin - related proteins ; caveolin has been re - termed caveolin - 1 .",
            "output": [
                "caveolin - 1"
            ]
        },
        {
            "id": "task1481-2ed4fb63a01e41f98455de07616a54df",
            "input": " DRAP27 is recognized by CD9 antibodies .",
            "output": [
                "CD9 antibodies"
            ]
        },
        {
            "id": "task1481-dd33144885fe4dd0b6550d7288b25441",
            "input": " A rare tRNA - Arg ( CCU ) that regulates Ty1 element ribosomal frameshifting is essential for Ty1 retrotransposition in Saccharomyces cerevisiae .",
            "output": [
                "Ty1 element"
            ]
        },
        {
            "id": "task1481-0defa3b68b804a1981b202a5d37b647d",
            "input": " p185c - neu + , EGFr + ( M1 ) , and p185c - neu - kinase inactive , EGFr + ( NEN757 ) expressing cells undergo different mitotic responses to EGF .",
            "output": [
                "EGFr +"
            ]
        },
        {
            "id": "task1481-a049390e3d014bf69a0537a0cea45eb7",
            "input": " An scrR promoter fragment , which dose not contain a sequence resembling OB , was not shifted by the fusion protein .",
            "output": [
                "scrR promoter fragment"
            ]
        },
        {
            "id": "task1481-8c0a75e7b0db416e85f3450a711badad",
            "input": " Each receptor must therefore engage a unique subset of the available signaling elements - - at least partly through the selection of proteins with src - homology 2 domains ( SH2 proteins ) .",
            "output": [
                "SH2 proteins"
            ]
        },
        {
            "id": "task1481-577f47200af3454eb7168e3eb93aae8d",
            "input": " The RTI40 gene spans 35 kilobase pairs ; it contains 6 exons and at least 6 rat Identifier repetitive elements .",
            "output": [
                "RTI40 gene"
            ]
        },
        {
            "id": "task1481-4e3efddd3dba43d8860542d3ce5a819c",
            "input": " Whereas the sequence of alpha - actinin ( Noegel , A . , W .",
            "output": [
                "alpha - actinin"
            ]
        },
        {
            "id": "task1481-0228f50ce4e94b5aa22ed081feaf0f95",
            "input": " The maternal par genes and the segregation of cell fate specification activities in early Caenorhabditis elegans embryos .",
            "output": [
                "maternal par genes"
            ]
        },
        {
            "id": "task1481-4f6e52417dc349ff8bf0311f581839cc",
            "input": " Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells : a comparison of the \" hot spot \" mutant phenotypes .",
            "output": [
                "p53 DNA"
            ]
        },
        {
            "id": "task1481-52af1edaf6c84a3397ed375c4466aa5d",
            "input": " Excess recombinant PTB squelches the splicing switch and reestablishes exon skipping as the predominant splicing pathway .",
            "output": [
                "recombinant PTB"
            ]
        },
        {
            "id": "task1481-aa4dcf4714d6419793b10cf258d34786",
            "input": " The program for myogenic differentiation is subject to negative control by several peptide growth factors and by the products of mutationally activated ras oncogenes , which persistently activate intracellular cascades normally triggered by specific growth factors .",
            "output": [
                "ras oncogenes"
            ]
        },
        {
            "id": "task1481-27a7842e87a444aa8cb744eb240a3e80",
            "input": " The BHV - 1 UL24 , UL25 , UL26 and UL26 . 5 transcripts all terminated at a common 3 ' - polyadenylation site and varied significantly in their relative abundance .",
            "output": [
                "UL26 . 5"
            ]
        },
        {
            "id": "task1481-1e7280aaee8442eab16af34889c1e42c",
            "input": " We discuss the possibility that DNA - protein interactions at homologous nucleotide sequences like those identified in PII are part of a regulatory gene cascade that participates in timing fla gene expression in the C . crescentus cell cycle .",
            "output": [
                "fla gene"
            ]
        },
        {
            "id": "task1481-0fec12ee79914084997f900e959bcde8",
            "input": " SF1 / mBBP utilizes a \" maxi - K homology \" ( maxi - KH ) domain for recognition of the single - stranded BPS and requires a cooperative interaction with splicing factor U2AF65 bound to an adjacent polypyrimidine tract ( PPT ) for high - affinity binding .",
            "output": [
                "maxi - KH"
            ]
        },
        {
            "id": "task1481-d5bc68476beb404593d7018248aea19d",
            "input": " In cells co - expressing high levels of the p38 ( MAPK ) kinase ( MKK3 ) together with the p38 ( MAPK ) , a significant inhibition of mitogen - induced cyclin D1 expression was observed .",
            "output": [
                "cyclin D1"
            ]
        },
        {
            "id": "task1481-f346be904961448b8b10e7cf06eae343",
            "input": " Sequence analysis identifies a ras - associating ( RA ) - like domain in the N - termini of band 4 . 1 / JEF domains and in the Grb7 / 10 / 14 adapter family .",
            "output": [
                "ras - associating"
            ]
        },
        {
            "id": "task1481-d0fd35e554034a279b32d83da5649205",
            "input": " Complementary DNA libraries from liver and ovary of an immature female channel catfish were screened with a homologous ERalpha cDNA probe .",
            "output": [
                "homologous ERalpha cDNA"
            ]
        },
        {
            "id": "task1481-266f182dabab47398f66a3ac387c0f2c",
            "input": " FdsR purified to homogeneity after overexpression of fdsR in E . coli is a 130 kDa homotetramer binding to the fds control region located between the fdsR and fdsG genes .",
            "output": [
                "fdsG genes"
            ]
        },
        {
            "id": "task1481-91f67aed731147b39aacbffad885c334",
            "input": " LT - beta transcription is maximal in the thymic medulla and in splenic white pulp .",
            "output": [
                "LT - beta"
            ]
        },
        {
            "id": "task1481-7a1769a45c884d758090b85bd5b4696e",
            "input": " The LT - beta gene is expressed in lymphoid cells and organs , but little is known about its inducible regulation .",
            "output": [
                "LT - beta"
            ]
        },
        {
            "id": "task1481-32b4daeb4ab54485a6a679d77003882d",
            "input": " Neither symptoms , virions , nor viral RNA was detectable in plants inoculated with this mutant or a mutant with a frameshift mutation in the coat gene .",
            "output": [
                "coat gene"
            ]
        },
        {
            "id": "task1481-ada908f3e00942828ab50670f86da756",
            "input": " The human CA11 gene appears to be located between the secretor type alpha ( 1 , 2 ) - fucosyltransferase gene cluster ( FUT1 - FUT2 - FUT2P ) and the D - site binding protein gene ( DBP ) on chromosome 19q13 . 3 .",
            "output": [
                "human CA11 gene"
            ]
        },
        {
            "id": "task1481-25e3f7dd8ba6424690ecd83143556058",
            "input": " Binding of C / EBPs to all three spi 2 . 3 3 ' UTR repressor sites , although rather weak , was confirmed by electrophoretic mobility shift assays that otherwise failed to reveal specific interactions with other liver nuclear proteins in vitro .",
            "output": [
                "C / EBPs"
            ]
        },
        {
            "id": "task1481-16a42febbeb34723888f6d15fc91d1fa",
            "input": " Transfection of both Calu - 6 and JEG - 3 cells with a PKA expression vector resulted in a 10 - fold induction of human renin transcriptional activity in constructs containing the native or consensus CRE and 5 - fold activation in a construct containing a nonfunctional CRE .",
            "output": [
                "human renin"
            ]
        },
        {
            "id": "task1481-965e654c121d4fa188a39a201cf80c9b",
            "input": " Following immunization of transgenic mice , hybrid molecules were isolated from B cell DNA which contained the transgene recombined with the endogenous IgH locus .",
            "output": [
                "endogenous IgH locus"
            ]
        },
        {
            "id": "task1481-908f0e0fee1d40b9a49340d09805ae1e",
            "input": " Indeed , DEX also enhanced the RA - dependent increase in RARbeta mRNA in a cycloheximide - sensitive manner .",
            "output": [
                "RARbeta mRNA"
            ]
        },
        {
            "id": "task1481-a98bf0ce8ae149749bef7e645942ce16",
            "input": " We have determined the complete cDNA sequence of rat plectin from a number of well - characterized overlapping lambda gt11 clones .",
            "output": [
                "rat plectin"
            ]
        },
        {
            "id": "task1481-21f6511dbcc44561b7fffdd9a449ef5a",
            "input": " At promoters that initiate with + 1 GGG , T7 RNAP synthesizes a ladder of poly ( G ) products as a result of slippage of the transcript on the three C residues in the template strand from + 1 to + 3 .",
            "output": [
                "T7 RNAP"
            ]
        },
        {
            "id": "task1481-8aa6c5c0197c4ea8a1a0e3f3311c57ef",
            "input": " Thus , in V . furnissii , the E . coli manX equivalent comprises two genes , which are separated in the genome by two other genes of the ptsM complex .",
            "output": [
                "ptsM complex"
            ]
        },
        {
            "id": "task1481-a5576e2ab1b5470f8e95e583152d075e",
            "input": " We report the complete nucleotide sequence of the camC gene along with 155 base pairs of 5 ' and 175 base pairs of 3 ' flanking sequence .",
            "output": [
                "camC gene"
            ]
        },
        {
            "id": "task1481-545a5a9128ef49c18e88968789eb4670",
            "input": " The POU - specific domain of Pit - 1 is essential for sequence - specific , high affinity DNA binding and DNA - dependent Pit - 1 - Pit - 1 interactions .",
            "output": [
                "Pit - 1"
            ]
        },
        {
            "id": "task1481-23be3faa8a464953ab96fcfbafaf359e",
            "input": " Our data indicate that the various subunits of the human P - TEFb complex may play distinct roles at multiple stages to mediate Tat activation of HIV - 1 transcription elongation .",
            "output": [
                "P - TEFb"
            ]
        },
        {
            "id": "task1481-9302cd5be7f44cde81cbbedc37af56ac",
            "input": " In this study we cloned the cDNA of AD1 Ag from a rat basophilic leukemia 2H3 cDNA library .",
            "output": [
                "AD1 Ag"
            ]
        },
        {
            "id": "task1481-471ed407c33c4e82b22b204036783aa3",
            "input": " A GT - rich sequence binding the transcription factor Sp1 is crucial for high expression of the human type VII collagen gene ( COL7A1 ) in fibroblasts and keratinocytes .",
            "output": [
                "transcription factor Sp1"
            ]
        },
        {
            "id": "task1481-fd25b7c2cdea45e297a94225e92892e5",
            "input": " Here we show that inhibition occurs with a NS1 - Rev chimera in which the 78 amino - terminal amino acids of the NS1A protein comprising its entire RNA - binding domain is deleted , thereby establishing that this carboxyl portion of the NS1A protein can function as an independent effector domain .",
            "output": [
                "NS1A protein"
            ]
        },
        {
            "id": "task1481-d1440f05d1a44d389eb026c68c496397",
            "input": " We also identified a DNA fragment , 10 . 7 kbp upstream from the first coding exon of human aFGF , whose sequence is conserved in both the primate and rodent genomes .",
            "output": [
                "human aFGF"
            ]
        },
        {
            "id": "task1481-3a543d5fd5f24b6e858266bb1df35cd5",
            "input": " Based on PCR strategies and expression studies , we define the genomic organization of the FUT8b gene .",
            "output": [
                "FUT8b gene"
            ]
        },
        {
            "id": "task1481-4fa9eebfce4e44bc937e6100cc5150a7",
            "input": " Tubular dysfunction in renal lithiasis : cause or consequence ? ] To investigate whether overall tubular dysfunction is encountered in a particular subgroup of patients with urolithiasis , the following parameters of renal tubular function have been measured in fasting morning urine in 124 male stone formers : excretion of lysozyme and gamma - glutamyl transpeptidase ( gamma - GT ) , fractional excretion ( FE ) or glucose , insulin , bicarbonate after an alkali load , and theoretical phosphate threshold ( TmP / GFR ) .",
            "output": [
                "gamma - GT"
            ]
        },
        {
            "id": "task1481-f782976ccd47406ba4de9e2e6c9a6928",
            "input": " They are transduced through TM to the cytoplasmic portion ( cytoloops and the C - terminal tail ) of the receptor and then , transferred to cytoplasmic signaling molecules , such as G protein .",
            "output": [
                "G protein"
            ]
        },
        {
            "id": "task1481-7ac854552e1544b8894d3e93c0f77d93",
            "input": " To further identify the residues responsible for the activity , we isolated the mutant viruses that were not neutralized with the soluble form of MHV receptor proteins , since such mutants were expected to have mutations in amino acids responsible for receptor - binding activity .",
            "output": [
                "MHV receptor proteins"
            ]
        },
        {
            "id": "task1481-6a3e6f7630264a2caa4863fd4666e159",
            "input": " To increase the number of circulating polymorphonuclear neutrophils , the patient was treated with recombinant granulocyte - macrophage colony - stimulating factor ( GM - CSF ) at a dose of 2 micrograms protein / kg bodyweight s . c . / 12 h .",
            "output": [
                "GM - CSF"
            ]
        },
        {
            "id": "task1481-30ceed2d7b2748bc962da439ef7da43a",
            "input": " Therefore , we have reevaluated the age - related changes in serum leptin levels and their relationship with adiposity and androgen levels in a large group of community dwelling men .",
            "output": [
                "serum leptin"
            ]
        },
        {
            "id": "task1481-eba5ea3ee8b94a8aa5c3b6e52917f7c8",
            "input": " The phosphoprotein pUL69 of human cytomegalovirus ( HCMV ) , which is a herpesvirus of considerable medical importance in immunosuppressed patients and newborns , has previously been identified as an early - late viral protein that can stimulate several viral and cellular promoters and thus exerts a rather broad activation pattern .",
            "output": [
                "phosphoprotein pUL69"
            ]
        },
        {
            "id": "task1481-6879e82f3ea8410ab6050a42fbd161d2",
            "input": " In contrast , T229E - p70s6k migrated more slowly in SDS - polyacrylamide gels , but demonstrated partial kinase activity ( approximately 20 % compared with the wild type ) .",
            "output": [
                "T229E - p70s6k"
            ]
        },
        {
            "id": "task1481-60ee976807884beb8ecae0a873154332",
            "input": " As a test of this hypothesis , we predicted that mice which have altered expression of class I gene products , the beta2 - microglobulin knockout mice , [ beta2m ( - / - ) ] , would develop Fe overload .",
            "output": [
                "beta2 - microglobulin"
            ]
        },
        {
            "id": "task1481-9d61af672061486c96be53d78ca6d408",
            "input": " Human CD38 , a leukocyte receptor and ectoenzyme , is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide + - converting enzymes : extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP - ribosyl cyclase .",
            "output": [
                "Human CD38"
            ]
        },
        {
            "id": "task1481-d444a4efb0f94f8086f2266aba4ac884",
            "input": " The leader peptide was hypothesized to inhibit ribosome release at the tnaC stop codon , thereby blocking Rho ' s access to the transcript .",
            "output": [
                "tnaC stop codon"
            ]
        },
        {
            "id": "task1481-0cfa480817f644eeba9d2614ef43a90a",
            "input": " These studies reveal that CREM , a tissue - specific factor , is expressed and regulated by gonadotropins in the ovary , that the predominant CREM transcripts encode the repressor protein ICER , and that ICER is capable of inhibiting cAMP - induced expression of the inhibin alpha - subunit gene .",
            "output": [
                "repressor protein ICER"
            ]
        },
        {
            "id": "task1481-d9af90e7a6b646af9eea30acd403bb4a",
            "input": " Next , to examine the regulation mechanism of CD44 / ERM interaction in vivo , we reexamined the immunoprecipitated CD44 / ERM complex from BHK cells and found that it contains Rho - GDP dissociation inhibitor ( GDI ) , a regulator of Rho GTPase .",
            "output": [
                "Rho GTPase"
            ]
        },
        {
            "id": "task1481-9f275e2d8a88440c84f32fefa8cd350c",
            "input": " Vav and Dbl are members of a novel class of oncogene proteins that share significant sequence identity in a approximately 250 - amino - acid domain , designated the Dbl homology domain .",
            "output": [
                "Dbl homology domain"
            ]
        },
        {
            "id": "task1481-362033b26f264f3888cf2940fa93a0a4",
            "input": " DNA elements recognizing NF - Y and Sp1 regulate the human multidrug - resistance gene promoter .",
            "output": [
                "NF - Y"
            ]
        },
        {
            "id": "task1481-ad50b44d928d400d8f032b72894a48f7",
            "input": " Furthermore , addition of the recombinant NF - YA subunit restores NF - Y binding .",
            "output": [
                "NF - Y"
            ]
        },
        {
            "id": "task1481-4e75a61cfbbb4776a7efa979a0c30397",
            "input": " Here we show that one nudF suppressor also suppresses hs - mutations in nudA , nudC , and nudG and deletions in nudA and nudF .",
            "output": [
                "nudF suppressor"
            ]
        },
        {
            "id": "task1481-714254729797456bb91e5c402810c87d",
            "input": " After 5 days stimulation with G - CSF ( 10 micrograms / kg ) 1l of blood was drawn , kept unprocessed for 3 days and reinfused 24 h after completion of chemotherapy .",
            "output": [
                "G - CSF"
            ]
        },
        {
            "id": "task1481-d74beed6c5d245e5b918c16b4b7e86b0",
            "input": " G - CSF ( 10 microg / kg ) was started on day + 1 and all patients engrafted within a median day number of 12 ( range , 10 - 22 ) until leukocytes > 1 . 0 x 10 ( 9 ) / l and a median day number of 56 ( range , 10 - 180 ) until platelets > 20 . 0 x 10 ( 9 ) / l ( ie platelet transfusion independence ) .",
            "output": [
                "G - CSF"
            ]
        },
        {
            "id": "task1481-8962f8961db140b19e43794aa494146c",
            "input": " We compared retrospectively the efficacy of granulocyte colony stimulating factor ( G - CSF ) alone with chemotherapy plus G - CSF in mobilizing CD34 - positive cells in patients with malignant lymphoma .",
            "output": [
                "G - CSF"
            ]
        },
        {
            "id": "task1481-650ea98502594a49a696a8ba55ddd9d0",
            "input": " We screened an A . thaliana cDNA library , whose inserts are under the control of the galactose - inducible GAL10 promoter , for cDNAs which enabled YDH8 cells to grow at the restrictive temperature .",
            "output": [
                "GAL10 promoter"
            ]
        },
        {
            "id": "task1481-c0363ceee13646cfa7469826f88f048a",
            "input": " Subclones of R15 which reverted to kappa light chain production contained genomic deletions of R15ns and / or the surrounding intron .",
            "output": [
                "kappa light chain"
            ]
        },
        {
            "id": "task1481-01bd979b8c1546be9a5a7aeb9d99ad54",
            "input": " Whether or not these novel repeated sequences throughout the SMA region are involved in the disease remains to be determined .",
            "output": [
                "SMA region"
            ]
        },
        {
            "id": "task1481-e9413e30c6bb4b27952d76795573e238",
            "input": " By a combination of alternative promoter usage and exon splicing , each ROR gene generates several isoforms that differ only in their amino terminus .",
            "output": [
                "ROR gene"
            ]
        },
        {
            "id": "task1481-9464e8bb780248b89475c205d5a4e967",
            "input": " We report the cloning of the ade1 gene on a 4 . 4 kb Sau3A insert in the yeast shuttle vector pWH5 .",
            "output": [
                "ade1 gene"
            ]
        },
        {
            "id": "task1481-a47f3bb708384f01b9781abf2cf1c361",
            "input": " Furthermore , the rapid light - mediated increase of CPRF proteins was insensitive to transcriptional inhibitors , suggesting that a post - transcriptional mechanism controls CPRF accumulation .",
            "output": [
                "CPRF proteins"
            ]
        },
        {
            "id": "task1481-0ae6b1ac80b44735b57f4882778da0f6",
            "input": " The pepI gene was overexpressed in Escherichia coli .",
            "output": [
                "pepI gene"
            ]
        },
        {
            "id": "task1481-b0e7b3e04bcd4489bdf043f73eaddbcf",
            "input": " The deduced amino - acid sequence of the mature enzyme showed very low homology ( < 20 . 4 % identity ) to those of known pectinolytic enzymes in the large pectate lyase superfamily ( the polysaccharide lyase family 1 ) .",
            "output": [
                "pectate lyase superfamily"
            ]
        },
        {
            "id": "task1481-ec4fb1c996424926902329e2f8b796b8",
            "input": " Presently , we made chain pair switch , chimeric , and site mutant gamma delta TCRs and transfected them into TCR - mutant Jurkat T cells to examine the effects of changing the TCR gamma junctional region sequences on reactivity to prenyl pyrophosphate Ags .",
            "output": [
                "prenyl pyrophosphate Ags"
            ]
        },
        {
            "id": "task1481-7672f42405714a15b480310d8071ef7e",
            "input": " Effectively , the upstream , housekeeping - type promoter responds to FIXK and positively regulates the downstream , sigma 54 - type promoter .",
            "output": [
                "sigma 54"
            ]
        },
        {
            "id": "task1481-2a90a3f4e85c469e8160c3d07aaeecd7",
            "input": " Muscle and liver biopsies demonstrated the same anomalies , again without branching enzyme deficiency in the liver .",
            "output": [
                "branching enzyme"
            ]
        },
        {
            "id": "task1481-b1e2db14c66f474899da38532640a74e",
            "input": " As a member of the uncoupling protein family , UCP2 is ubiquitously expressed in rodents and humans , implicating a major role in thermogenesis .",
            "output": [
                "uncoupling protein family"
            ]
        },
        {
            "id": "task1481-3d57c17e5f42489da65cf58b2aa92827",
            "input": " The herpesvirus entry mediator C ( HveC ) , previously known as poliovirus receptor - related protein 1 ( PRR1 ) , and the herpesvirus Ig - like receptor ( HIgR ) are the bona fide receptors employed by herpes simplex virus - 1 and - 2 ( HSV - 1 and - 2 ) for entry into the human cell lines most frequently used in HSV studies .",
            "output": [
                "poliovirus receptor"
            ]
        },
        {
            "id": "task1481-f331185bbf254c98908d40ad184af46d",
            "input": " Upstream of the afa - 3 gene cluster , a 1 . 2 - kb region was found to be 96 % identical to the RepFIB sequence of one of the enterotoxigenic E . coli plasmids ( P307 ) , suggesting a common ancestor plasmid .",
            "output": [
                "RepFIB sequence"
            ]
        },
        {
            "id": "task1481-4dccc45190ad4400abdd92b476dbacbd",
            "input": " Insulin therapy has been expanded by development of human insulin and new modes of injection , including insulin pumps .",
            "output": [
                "human insulin"
            ]
        },
        {
            "id": "task1481-e90cd90e8ddb477b8107da9a4217aa90",
            "input": " A V1 mutant generated in vivo with 11 of the 14 N - terminal amino acids altered , was viable and produced symptoms typical of a wild - type infection .",
            "output": [
                "V1 mutant"
            ]
        },
        {
            "id": "task1481-2dba2b079d074359ac7794f702e42e46",
            "input": " We propose that U73 is involved in methylation of the G1739 residue of the human 28S rRNA .",
            "output": [
                "human 28S rRNA"
            ]
        },
        {
            "id": "task1481-b5ee85b57cdd4d9fb685d50ddd0ddab5",
            "input": " Here we show that these sequences are essential for processing of U18 and snR38 snoRNAs and that they compensate for the lack of a canonical terminal stem .",
            "output": [
                "snR38 snoRNAs"
            ]
        },
        {
            "id": "task1481-00faef28d3304140bf6af7e4871fc592",
            "input": " We have isolated two H19 cDNAs ( AP and ES ) that contain this ORF4 and correspond to incomplete copies of the unique 2 . 3 kb H19 RNA .",
            "output": [
                "H19 cDNAs"
            ]
        },
        {
            "id": "task1481-7bcfb1783a744e6180528e7b0c3c6bc8",
            "input": " Nine months after the end of the vaccination anti - HBsAg levels had dropped to 9 + / - 4 IU / 1 ( M + / - SE ) , with a geometric mean of 5 IU / 1 , in the nine remaining evaluable patients .",
            "output": [
                "anti - HBsAg"
            ]
        },
        {
            "id": "task1481-7856b893488943a487ec9e64f572000e",
            "input": " Here , we characterize TCR / CD48 and TCR / CD28 costimulation in T cells expressing Lck Src homology 3 ( SH3 ) mutants .",
            "output": [
                "Src homology 3"
            ]
        },
        {
            "id": "task1481-7ec09fca43814c8a88cdfcc5c1d47b5b",
            "input": " The NF - kappa B precursor p100 ( lyt - 10 , p97 , p98 ) generates after proteolytic processing a 52 kDa subunit , which can bind to kappa B - motifs .",
            "output": [
                "lyt - 10"
            ]
        },
        {
            "id": "task1481-4d20c77c78ba47a38edd686cfe0cae44",
            "input": " Blockade of T cell activation using a surface - linked single - chain antibody to CTLA - 4 ( CD152 ) .",
            "output": [
                "CTLA - 4"
            ]
        },
        {
            "id": "task1481-5ac35b4e57174080ac9cd12ed39440f0",
            "input": " Overexpression of SNURF in cultured mammalian cells enhanced not only androgen , glucocorticoid , and progesterone receptor - dependent transactivation but also basal transcription from steroid - regulated promoters .",
            "output": [
                "progesterone receptor"
            ]
        },
        {
            "id": "task1481-167c87da4be54531a21425e267a43a34",
            "input": " These two enhancer elements also enhanced transcription when fused separately to the basal promoter region of the chicken vimentin gene .",
            "output": [
                "chicken vimentin gene"
            ]
        },
        {
            "id": "task1481-5529cda4395d480dad18668854d0becd",
            "input": " The results suggest that both superficial and deep cortical venous drainage of the cat kidney should be considered when measuring renal renin release .",
            "output": [
                "renal renin"
            ]
        },
        {
            "id": "task1481-84c3d9f8db0e4382b5ff4cb731614572",
            "input": " Maximum overexpression of holoenzyme activity was achieved by the inclusion in such plasmids of Salmonella typhimurium cysG , which encodes a uroporphyrinogen III methyltransferase required for the synthesis of siroheme , a cofactor for the hemoprotein .",
            "output": [
                "uroporphyrinogen III methyltransferase"
            ]
        },
        {
            "id": "task1481-62a44097d38d41aca9e4bd5cae02418f",
            "input": " Thus , the potential induction of this gene rearrangement by E1A gene therapy is unlikely to be clinically significant in the treatment of advanced malignant disease .",
            "output": [
                "E1A gene"
            ]
        },
        {
            "id": "task1481-4cd1516993d3457cb401b96949e4c25a",
            "input": " NSD1 contains a SET domain and multiple PHD fingers .",
            "output": [
                "SET domain"
            ]
        },
        {
            "id": "task1481-a17cbe5b009e452eac04c9a559aa3590",
            "input": " A cDNA for human microfibril - associated glycoprotein - 2 ( MAGP - 2 ) was used to screen a human leukocyte genomic DNA library in EMBL - 3 vector .",
            "output": [
                "MAGP - 2"
            ]
        },
        {
            "id": "task1481-e86090c2f5bf436fa36cd0dd5593bf44",
            "input": " Recombinant Human Erythropoietin and Platinum - Based Chemotherapy In Advanced Ovarian Cancer",
            "output": [
                "Recombinant Human Erythropoietin"
            ]
        },
        {
            "id": "task1481-900e019b95184335aee2c09f64190fc5",
            "input": " The UL3 ORF of 204 amino acids shows significant homology to UL3 ( nuclear phosphoprotein ) of HSV - 1 ( 62 % ) and PRV ( 53 % ) .",
            "output": [
                "UL3 ORF"
            ]
        },
        {
            "id": "task1481-78ff10ded1c94cb89152f79ab85796e2",
            "input": " In human myxoid liposarcoma , a chromosomal rearrangement leads to fusion of the growth - arresting and DNA - damage - inducible transcription factor CHOP ( GADD153 ) to a peptide fragment encoded by the TLS gene .",
            "output": [
                "TLS gene"
            ]
        },
        {
            "id": "task1481-e7c82762683e449ea6bec7de9e044127",
            "input": " Engineering temperature - sensitive SH3 domains .",
            "output": [
                "SH3 domains"
            ]
        },
        {
            "id": "task1481-2cf0d19a07724f8485b0dd3fa90ca3c2",
            "input": " SH3A competes with the SH3 domains of Grb2 in binding to mSos1 , and the intersectin - mSos1 complex can be separated from Grb2 by sucrose gradient centrifugation .",
            "output": [
                "SH3 domains"
            ]
        },
        {
            "id": "task1481-9bd63e853db64a09a23137f74eb70fcb",
            "input": " The mRNA for this protein is expressed in the T - ALL cell line Jurkat and has been designated HUG1 , for HOX11 Upstream Gene .",
            "output": [
                "HOX11 Upstream Gene"
            ]
        },
        {
            "id": "task1481-12cb668266a84497b218b34437b90b8f",
            "input": " Blood samples for determination of fibrinolytic activity and factor VIII in plasma were obtained before and immediately after the end of compression and application of a stocking , respectively .",
            "output": [
                "factor VIII"
            ]
        },
        {
            "id": "task1481-1523eb04c30a42339bac533aaf284e59",
            "input": " A simple procedure for accurate quantitation of factor VIII inhibitors .",
            "output": [
                "factor VIII"
            ]
        },
        {
            "id": "task1481-6aeee604cb3a47908d5feca34c8d497f",
            "input": " The sections were stained with anti - polymorphonuclear leukocyte antibody , the endothelial marker factor VIII - related antigen , and with hematoxylin and eosin .",
            "output": [
                "factor VIII"
            ]
        },
        {
            "id": "task1481-f054dcd4bc0b458aa716f40b6ee8228c",
            "input": " The authors recommend in cases with an elevated transaminase serum activity more frequent check - up examinations to avoid missing of a relapse , and to examine repeatedly IgM anti - HAV as in protracted forms of hepatitis IgM anti - HAV may persist even when the transaminase activity is normal .",
            "output": [
                "anti - HAV"
            ]
        },
        {
            "id": "task1481-4672713002be4950af85d23168fb6d54",
            "input": " The aromatic hydrocarbon receptor ( AHR ) is a ligand - activated transcription factor that regulates the expression of several drug - metabolizing enzymes and has been implicated in immunosuppression , teratogenesis , cell - specific hyperplasia , and certain types of malignancies and toxicities .",
            "output": [
                "aromatic hydrocarbon receptor"
            ]
        },
        {
            "id": "task1481-fbc41b2ca27747cb927e912fb8d08a78",
            "input": " Therefore , a structural interaction between PsaL and PsaI may stabilize the association of PsaL with the photosystem I core .",
            "output": [
                "photosystem I core"
            ]
        },
        {
            "id": "task1481-8d3d83d51fe841909147da7adc9f912e",
            "input": " Elements regulating cell - and stage - specific expression of the C . elegans MyoD family homolog hlh - 1 .",
            "output": [
                "hlh - 1"
            ]
        },
        {
            "id": "task1481-141c876275794a3ca73c1c797f4c18f8",
            "input": " CONCLUSIONS - - Postlumbar puncture headache may be mediated by the release of substance P triggered by lumbar puncture , in patients predisposed to headache by a hypersensitivity to substance P .",
            "output": [
                "substance P"
            ]
        },
        {
            "id": "task1481-fc301def263c47afa79d04fbf1a2b236",
            "input": " The treatment with glucocorticoids and immunosuppressants resulted in a more noticeable decrease in the levels of T3 and E - RCF .",
            "output": [
                "E - RCF"
            ]
        },
        {
            "id": "task1481-000cf786a5ad4ad19a141d9593f2aae4",
            "input": " Characterization of a unique protein component of yeast RNase MRP : an RNA - binding protein with a zinc - cluster domain .",
            "output": [
                "yeast RNase MRP"
            ]
        },
        {
            "id": "task1481-c4339ae6e59946938981cfd7d3642265",
            "input": " To clone cDNAs for the beta subunit of rabbit eIF - 2B , amino acid sequence data was first obtained and used to design redundant oligonucleotide primers for use in PCR .",
            "output": [
                "eIF - 2B"
            ]
        },
        {
            "id": "task1481-66e9bfdfad314e2fbcedc4c126a3ce38",
            "input": " The human parvalbumin mRNA contains the putative polyadenylation signal AATAAA 13 nucleotides upstream from the polyadenylation site .",
            "output": [
                "human parvalbumin mRNA"
            ]
        },
        {
            "id": "task1481-f87e6bad10ee4de99c2802155c293bae",
            "input": " No promoter activity could be detected with various mouse Fli - 1 promoter - CAT constructs containing 600 bp of the 5 ' flanking region , the complete exon 1 , the 5 ' end of intron 1 and / or retroviral LTR sequence .",
            "output": [
                "Fli - 1"
            ]
        },
        {
            "id": "task1481-3684ff98e197406988096567206b0b93",
            "input": " Analysis of the DNA - binding and transcriptional activation functions of human Fli - 1 protein .",
            "output": [
                "Fli - 1"
            ]
        },
        {
            "id": "task1481-5caaebad933e46f69ffc37ce3c1738df",
            "input": " Fli - 1 is a proto - oncogene which is rearranged in tumors induced by three different retroviruses , Cas - Br - E , F - MuLV , and 10A1 .",
            "output": [
                "Fli - 1"
            ]
        },
        {
            "id": "task1481-2fe79996e31048bdb06991cbdac24a4e",
            "input": " We identify YY1 recognition sequences within the vitamin D response element ( VDRE ) of the osteocalcin gene that are critical for YY1 - dependent repression of vitamin D - enhanced promoter activity .",
            "output": [
                "osteocalcin gene"
            ]
        },
        {
            "id": "task1481-8f123687865945bca9c9eab0edea8d18",
            "input": " Identification of an osteocalcin gene promoter sequence that binds AP1 .",
            "output": [
                "osteocalcin gene"
            ]
        },
        {
            "id": "task1481-4b0091d77ae74905b4c3542077b383c2",
            "input": " Unestablished quail myoblasts were infected with a retroviral vector encoding the oncogenic form of H - Ras in order to investigate the mechanism by which this oncoprotein interferes with terminal differentiation .",
            "output": [
                "H - Ras"
            ]
        },
        {
            "id": "task1481-e3f27a6863aa4b9cbf2de71e77ae802d",
            "input": " Our results show that unlike the case for sos1 , sos2 gene function is dispensable for normal mouse development , growth , and fertility .",
            "output": [
                "sos2 gene"
            ]
        },
        {
            "id": "task1481-4511eedc65a14fd2a3ccb6ead203e35e",
            "input": " Creatinine and creatine phosphokinase ( CPK ) .",
            "output": [
                "creatine phosphokinase"
            ]
        },
        {
            "id": "task1481-124569204a754b4e90b3526823e77139",
            "input": " Central ( heart rate , VE , VO2 ) or local ( muscle and blood lactate , adenosine triphosphate , creatine phosphokinase , glycogen ) cues highlighted in these studies demonstrate both the complexity of effort perception , and the need for better understanding of the physiological components upon which it is based .",
            "output": [
                "creatine phosphokinase"
            ]
        },
        {
            "id": "task1481-70804137fa2c48c189551462238c11d0",
            "input": " INTERVENTIONS : Postoperative follow - up consisted of serial determination of different biochemical markers ( CK , CK - MB , cTnI ) , ECGs , and echocardiography .",
            "output": [
                "CK - MB"
            ]
        },
        {
            "id": "task1481-1bee4961a3554f88b97360820c0d72fc",
            "input": " Our case , however , had no histologic evidence of malignancy , no serum alpha fetoprotein at 7 months of age , and no recurrence at 1 years .",
            "output": [
                "serum alpha fetoprotein"
            ]
        },
        {
            "id": "task1481-4150f11ad29b42e1a22fefaade482a0a",
            "input": " Although hSSTR5 displays approximately 75 % sequence identity with rat SSTR5 , the two receptors display significantly different pharmacological profiles , especially with respect to their binding affinities for the SST analogue SMS 201 - 995 .",
            "output": [
                "rat SSTR5"
            ]
        },
        {
            "id": "task1481-2664c47da9c147c48190c0712f9edec1",
            "input": " Phytohemagglutinin ( PHA ) , the seed lectin of the common bean , accumulates in protein storage vacuoles of storage parenchyma cells in cotyledons .",
            "output": [
                "seed lectin"
            ]
        },
        {
            "id": "task1481-f3763583cb4c4e16b1438313d224fee7",
            "input": " The non - major histocompatibility complex ( MHC ) - encoded CD1 family has recently emerged as a new antigen - presenting system that is distinct from either MHC class I or class II molecules .",
            "output": [
                "CD1 family"
            ]
        },
        {
            "id": "task1481-8d23a1d32850472283b073dd64995098",
            "input": " The present study also emphasizes the need of establishing dose - response curves to correctly assess the relative contribution of the different regions of steroid hormone receptors in activation of transcription .",
            "output": [
                "steroid hormone receptors"
            ]
        },
        {
            "id": "task1481-e8ceb01a1917443c8c7ad0fbeacadea6",
            "input": " Due to significant homology to the C - terminus of the Mutator transposase this alternative gene product was named Trap ( transposon - associated protein ) .",
            "output": [
                "Mutator transposase"
            ]
        },
        {
            "id": "task1481-f8636690ec404f849c6b067090dcd614",
            "input": " By contrast , footprint II at position - 125 is common to both HeLa and GH3 cell extracts and overlies a 15 - base - pair sequence found in all members of the growth hormone gene family .",
            "output": [
                "growth hormone"
            ]
        },
        {
            "id": "task1481-a9511ce8b3b04c008641c398f92094a2",
            "input": " In both study stages . post - exposure treatment consisted of five injections of vaccine [ ( D ) ays 0 , 3 , 7 , 14 , 28 ] , together with a dose of rabies immunoglobulin ( RIG ) of equine or human origin on D0 .",
            "output": [
                "rabies immunoglobulin"
            ]
        },
        {
            "id": "task1481-458ada59c218449d9311f53d5644220a",
            "input": " The coding region of nifA was determined using a translational lacZ fusion and by site - directed mutagenesis to identify which of four in frame AUG codons was used .",
            "output": [
                "lacZ fusion"
            ]
        },
        {
            "id": "task1481-7ed79f0b5f8f438fa701f9e5a1925f3e",
            "input": " In the plant malate synthases , the extension is probably involved in routing to the microbodies , since it contains the potential peroxisomal targeting signal , Ser - Arg / Lys - Leu , at the carboxy terminus .",
            "output": [
                "plant malate synthases"
            ]
        },
        {
            "id": "task1481-8e426be564d741b3827394249aceddba",
            "input": " The gene atp6 , encoding subunit 6 of the mitochondrial F0 - ATPase complex , has been characterized from both the normal ( fertile ) and Ogura ( male - sterile ) radish cytoplasms in order to determine if previously identified atp6 transcriptional differences could play a role in cytoplasmic male sterility .",
            "output": [
                "gene atp6"
            ]
        },
        {
            "id": "task1481-8199e2cc504b45f6aec24e2975d563dd",
            "input": " However , in a variation of this assay in which the protease is omitted , the mutant enzymes exhibited substantial levels of prolyl isomerase activity ( 5 - 20 % of wild - type ) , revealing that these mutations confer sensitivity to protease digestion and that the classic in vitro assay for prolyl isomerase activity may be misleading .",
            "output": [
                "prolyl isomerase"
            ]
        },
        {
            "id": "task1481-52f4c347c1ed496294a700d6a885cca0",
            "input": " In the spontaneous abortion group , the levels of PAPP - A were significantly lower than in normal pregnancy but higher than in non - pregnant controls .",
            "output": [
                "PAPP - A"
            ]
        },
        {
            "id": "task1481-23ec5f2d8f18496ab9d4c681e3fb3910",
            "input": " The 5 - HT3 antagonist ondansetron reduced alcohol intake in both the medium and high alcohol preferring rats at doses between 0 . 01 and 0 . 16 mg / kg .",
            "output": [
                "5 - HT3"
            ]
        },
        {
            "id": "task1481-d8fb68aaee1649cba3fe3355d0fd6a40",
            "input": " We then isolated the full - length coding region of the human BACH1 gene using expressed sequence tags , reverse transcription - polymerase chain reaction and rapid amplification of cDNA ends .",
            "output": [
                "human BACH1 gene"
            ]
        },
        {
            "id": "task1481-6bb486b0d66842a4a578d80590bdfec6",
            "input": " Clinical development of interleukin - 10 .",
            "output": [
                "interleukin - 10"
            ]
        },
        {
            "id": "task1481-07bbe52a465e48759da57470b4afa151",
            "input": " A protein which promotes DNA strand transfer between linear double - stranded M13mp19 DNA and single - stranded viral M13mp19 DNA has been isolated from recA - E . coli .",
            "output": [
                "recA -"
            ]
        },
        {
            "id": "task1481-3d036eddf32742e8be2d68f06132f9a0",
            "input": " An insertion sequence element ( IS1170 ) was identified upstream of the nimC gene .",
            "output": [
                "nimC gene"
            ]
        },
        {
            "id": "task1481-8f61a60e5cad4d63bfe03b2cf09f19b7",
            "input": " Two human beta - 1 , 6 - N - acetylglucosaminyltransferases forming the core 2 O - glycan branch , C2GnT and the I antigen , IGnT , are homologous to each other in three regions of the catalytic domain ( A , B , C ) and their genes reside at the same locus , chromosome 9 , band q21 ( Bierhuizen , M . F . A . , Mattei , M . - G . and Fukuda , M . , Genes Dev . , 7 , 468 - 478 , 1993 ) .",
            "output": [
                "I antigen"
            ]
        },
        {
            "id": "task1481-871d35f50d8e466680768804569c9092",
            "input": " These studies suggest that tandem alpha - helices located near the C - terminus of PC - TP facilitate membrane binding and extraction of phosphatidylcholines .",
            "output": [
                "PC - TP"
            ]
        },
        {
            "id": "task1481-3bfd642a7f524863a8df69fcc36bdc69",
            "input": " Internalization of prolactin receptor and prolactin in transfected cells does not involve nuclear translocation .",
            "output": [
                "prolactin receptor"
            ]
        },
        {
            "id": "task1481-a34f6cfadfe545e6b2877d048a3cb915",
            "input": " We speculate that the enhancing effect of glucose and galactose on fructose absorption may be due to activation of the fructose carrier .",
            "output": [
                "fructose carrier"
            ]
        },
        {
            "id": "task1481-ea31c9b8cec34785bd269641882b042d",
            "input": " Role of zinc - finger proteins Sp1 and zif268 / egr - 1 in transcriptional regulation of the human synaptobrevin II gene .",
            "output": [
                "egr - 1"
            ]
        },
        {
            "id": "task1481-f7cd2a481f1644d7835b1a0b7bf02b4e",
            "input": " The Pi signals are conveyed to PHO8 by binding of PHO4 protein , a positive regulatory factor , to a promoter region of PHO8 ( PHO8p ) under the influence of the PHO regulatory circuit .",
            "output": [
                "PHO4 protein"
            ]
        },
        {
            "id": "task1481-e5594958b11f47edbd1808055127aaf4",
            "input": " This growth - inhibitory effect was suppressed by the mpk1 delta mutation , suggesting that hyperactivation of the Mpk1 pathway is toxic to cells .",
            "output": [
                "mpk1 delta"
            ]
        },
        {
            "id": "task1481-12136fbb33fe4821a0722b07712987ae",
            "input": " The presence of a short ( 70 bp ) intron near the N - terminus of the atX gene was predicted that contains the canonical GT and AG dinucleotides at its 5 ' - and 3 ' - splicing junctions .",
            "output": [
                "atX gene"
            ]
        },
        {
            "id": "task1481-58a0dd01d0154083a1e661f4b9435bdf",
            "input": " Both merR genes consist of a 408 bp ORF coding for 135 amino acids .",
            "output": [
                "merR genes"
            ]
        },
        {
            "id": "task1481-ddfe9f022c75439fbe3f2ad6be69933e",
            "input": " The effect of the negative regulatory element is negated by the viral IE2 protein ( L .",
            "output": [
                "viral IE2 protein"
            ]
        },
        {
            "id": "task1481-43d3225aeecc4bbb91c85decc9fc2b5b",
            "input": " Characterization of a cDNA encoding CNN predicts a novel structural protein with three leucine zipper motifs and several coiled - coil domains exhibiting limited homology to the rod portion of myosin .",
            "output": [
                "cDNA encoding CNN"
            ]
        },
        {
            "id": "task1481-d2525f027c2840918d282296485cd1ce",
            "input": " Isolation and properties of Drosophila melanogaster ferritin - - molecular cloning of a cDNA that encodes one subunit , and localization of the gene on the third chromosome .",
            "output": [
                "Drosophila melanogaster ferritin"
            ]
        },
        {
            "id": "task1481-ad189b09e7a942e989801c83f33b9423",
            "input": " Unlike CSK , the SH3 domain of HYL was unique since the ALYDY motif was absent .",
            "output": [
                "SH3 domain"
            ]
        },
        {
            "id": "task1481-73d10914b2864df59d13fda6be29d452",
            "input": " Furthermore , Grap is associated with a Ras guanine nucleotide exchange factor mSos1 , primarily through its N - terminal SH3 domain .",
            "output": [
                "SH3 domain"
            ]
        },
        {
            "id": "task1481-564dd983a05840daacc3ecef6de48801",
            "input": " The human protein binds most strongly to the SH3 domain from the abl proto - oncogene .",
            "output": [
                "SH3 domain"
            ]
        },
        {
            "id": "task1481-e4ed56aaa7964e51a852c297066227fd",
            "input": " In this study , a site of PDGF - induced tyrosine phosphorylation was mapped to Tyr 138 in the SH3 domain ; Tyr 138 is exposed on the SH3 peptide binding surface .",
            "output": [
                "SH3 domain"
            ]
        },
        {
            "id": "task1481-f5e338c713454d999534c6941534ce5b",
            "input": " A significant difference in the distribution of antibodies to thyroglobulin and thyroid peroxidase was found in subgroup 2 .",
            "output": [
                "thyroid peroxidase"
            ]
        },
        {
            "id": "task1481-75c8a0497d154787b965f39459444479",
            "input": " Two different genes ( polA and polB ) encoding family B DNA polymerases were cloned from the organism by PCR using degenerated primers based on the two conserved motifs ( motif A and B ) .",
            "output": [
                "DNA polymerases"
            ]
        },
        {
            "id": "task1481-2949551f2ffd4751ac52dbae4359e5b9",
            "input": " Examination of the Coomassie - stained gels revealed that the capsid - like particles composed of the N11 - VP1 protein did not contain any host - derived histones .",
            "output": [
                "N11 - VP1"
            ]
        },
        {
            "id": "task1481-e4b2520ecaf743f58e85f00d007cca5c",
            "input": " In addition , mrp17 - 1 , in combination with some mutations affecting another mitochondrial ribosomal protein , caused a synthetic defective phenotype .",
            "output": [
                "mrp17 - 1"
            ]
        },
        {
            "id": "task1481-4fb8a303208347c49cc4abab8d82ad3b",
            "input": " These 8 - oxoguanine DNA glycosylases , hOgg1 ( human ) and mOgg1 ( murine ) , are homologous to each other and to yeast Ogg1 .",
            "output": [
                "yeast Ogg1"
            ]
        },
        {
            "id": "task1481-0bdc4709b9924c8096282735b6c5de7b",
            "input": " In cases of intracapsular prostatic cancer the level of prostatic acid phosphatase ( PAP ) measured by radioimmunoassay was 1 . 4 + / - 0 . 8 micrograms / l .",
            "output": [
                "prostatic acid phosphatase"
            ]
        },
        {
            "id": "task1481-af99998f7b3945ccbbf2dc4b308df96d",
            "input": " On the basis of experiments with mutant virus and transfection with isolated genes , the herpes simplex virus immediate - early gene product ICP4 is known to positively regulate the transcription of viral early and late genes and negatively regulate expression from its own promoter .",
            "output": [
                "early gene"
            ]
        },
        {
            "id": "task1481-92cbb86fb1034036b86f224595fb2fb6",
            "input": " The IR4 ORF exhibits significant homology to the immediate - early gene US1 ( ICP22 ) of herpes simplex virus type 1 and to the ICP22 homologs of varicella - zoster virus ( ORF63 ) , pseudorabies virus ( RSp40 ) , and equine herpesvirus 4 ( ORF4 ) .",
            "output": [
                "early gene"
            ]
        },
        {
            "id": "task1481-f0b82eb544d24c9c9701df054b0c3bb9",
            "input": " Vibrio cholerae iron transport : haem transport genes are linked to one of two sets of tonB , exbB , exbD genes .",
            "output": [
                "exbD genes"
            ]
        },
        {
            "id": "task1481-f59218fa090f4abba96a760776be4275",
            "input": " When the opioid antagonist was administered to animals 24 hr after termination of single or multiple exposures to restraint , NALT - induced increases in basal plasma LH were significantly attenuated in the chronically stressed rats compared to animals subjected to stress only once or not at all . ( ABSTRACT TRUNCATED AT 250 WORDS )",
            "output": [
                "plasma LH"
            ]
        },
        {
            "id": "task1481-360e3f524d654f77982e794318bfe231",
            "input": " Serum prolactin and oestradiol levels at different stages of puberty .",
            "output": [
                "Serum prolactin"
            ]
        },
        {
            "id": "task1481-3cbb668c5c2b47b3a1bfb8e6d4165c3d",
            "input": " Serum prolactin rapidly decreased after institution of treatment , with actual normalization ( less than 20 ng / ml ) by the 3rd month .",
            "output": [
                "Serum prolactin"
            ]
        },
        {
            "id": "task1481-7769a31b7032493cb5fde35dec4eb43b",
            "input": " Northern analyses further confirm that the expression of endogenous alpha - ENaC gene in salivary Pa - 4 cells is suppressed by an ectopic HMGI - C overexpression .",
            "output": [
                "HMGI - C"
            ]
        },
        {
            "id": "task1481-4087c1ff735f4827b4a299b53e8820c3",
            "input": " The oxalate oxidase method results in a mean and reference interval for oxalate excretion that are comparable with those by isotope dilution , gas - chromatographic , colorimetric , and other enzymic procedures .",
            "output": [
                "oxalate oxidase"
            ]
        },
        {
            "id": "task1481-2363367202b44198a5c6d404686dc1a7",
            "input": " Instead , the large difference in ssDNA - binding affinities reflects the loss of hexamerization ability by uvsY , suggesting that a form of intrahexamer synergism or cooperativity between binding sites within the uvsY hexamer leads to its high observed affinity for ssDNA .",
            "output": [
                "uvsY hexamer"
            ]
        },
        {
            "id": "task1481-2a051deaaf914b61a8d5a622936d2271",
            "input": " A mammalian protein called RFX or NF - X binds to the X box ( or X1 box ) in the promoters of a number of major histocompatibility ( MHC ) class II genes .",
            "output": [
                "NF - X"
            ]
        },
        {
            "id": "task1481-cbc3935d0e134c4ea030084827fff6b9",
            "input": " 4 ) Mutation of the three extracellular cysteine residues of GFKAR beta indicated that the two conserved cysteine residues ( C305 and C385 ) , located between two transmembrane segments , form a solvent - accessible disulfide bond .",
            "output": [
                "GFKAR beta"
            ]
        },
        {
            "id": "task1481-7d3dfcdc199f43a7bf4ba8869761a93f",
            "input": " Interestingly , the NES mutant proteins appeared to have altered interactions with the splicing complex , binding more tightly to SC35 in co - immunoprecipitation assays .",
            "output": [
                "NES mutant proteins"
            ]
        },
        {
            "id": "task1481-8cdf8054b02d49f1a1587f05136c1a24",
            "input": " Mutations that extend the specificity of the endonuclease activity of lambda terminase .",
            "output": [
                "lambda terminase"
            ]
        },
        {
            "id": "task1481-c3dd7248cd5940ef82ff099d985bc188",
            "input": " Changes in testicular testosterone and acid and alkaline phosphatase activity in testis and accessory sex organs after induction of varicocele in Noble rats .",
            "output": [
                "alkaline phosphatase"
            ]
        },
        {
            "id": "task1481-57dbd0e4edb9460baedb95f3f5dbe127",
            "input": " The relation between the changes of bone density and the level of blood calcium , blood phosphorus and alkaline phosphatase ( AKP ) as well as the metabolism of vitamin D was studied .",
            "output": [
                "alkaline phosphatase"
            ]
        },
        {
            "id": "task1481-ec046e6859664d4e93c640e1e104f9fa",
            "input": " Surprisingly , in adult animals , the suprabasal expression of dnRXR alpha significantly reduced the ability of topically applied tRA to stimulate proliferation of undifferentiated keratinocytes in the basal layer of epidermis .",
            "output": [
                "dnRXR alpha"
            ]
        },
        {
            "id": "task1481-84567dc466c24302bd1e8d02b87d2a19",
            "input": " They are growth - inhibited by TGF - beta1 .",
            "output": [
                "TGF - beta1"
            ]
        },
        {
            "id": "task1481-579bb49e68d741458d00ddb6320f1dc2",
            "input": " TGF - beta1 induced phosphorylation of Smad2 and Smad3 in Mv1Lu mink lung epithelial cells .",
            "output": [
                "TGF - beta1"
            ]
        },
        {
            "id": "task1481-be2d2e80db584feeaad6d24ddbfcdafc",
            "input": " This regulation is mediated by several kinases that phosphorylate specific residues in the different functional domains of the p53 molecule .",
            "output": [
                "p53 molecule"
            ]
        },
        {
            "id": "task1481-3426b9a48254419cb7cb6d7dab741df5",
            "input": " Because c - myb encodes a transcriptional activator that functions via DNA binding , it is likely that c - myb exerts its biological activity by regulating the transcription of genes required for DNA synthesis and cell cycle progression .",
            "output": [
                "c - myb"
            ]
        },
        {
            "id": "task1481-b8d6522641e24300810a7a0f6a7ccfec",
            "input": " During hexamethylene bisactamide ( HMBA ) - induced differentiation of murine erythroleukemia ( MEL ) cells erythroid genes are transcriptionally activated while c - myb and several other nuclear proto - oncogenes are down - regulated .",
            "output": [
                "c - myb"
            ]
        },
        {
            "id": "task1481-6771a1fed9704d91af1c45b022e2f812",
            "input": " A regulatory element of the empty spiracles homeobox gene is composed of three distinct conserved regions that bind regulatory proteins .",
            "output": [
                "empty spiracles"
            ]
        },
        {
            "id": "task1481-3a6c32ccac6049e0a391816094c0bd79",
            "input": " The increments in median plasma secretin concentration were 1 . 6 , 3 . 0 , and 6 . 4 pmol x 1 ( - 1 ) after secretin , 125 , 250 and 500 fmol x kg - 1 , and the corresponding 15 - min bicarbonate output 283 , 442 , and 1435 micromol , respectively .",
            "output": [
                "plasma secretin"
            ]
        },
        {
            "id": "task1481-77ac75f8cb714effa8993d2e68247f9c",
            "input": " To better understand the relationship between expression of an oncogene and genetic instability , we have studied a cell line expressing an activated human Ha - ras under the control of bacterial lactose operon regulatory elements for changes in methotrexate resistance and dihydrofolate reductase ( dhfr ) gene amplification following mutant Ha - ras induction .",
            "output": [
                "dihydrofolate reductase"
            ]
        },
        {
            "id": "task1481-1bb40e31146148248f527b841f2f174f",
            "input": " Three experiments using 20 microM 2 - ( hydroxyamino ) - 1 - methyl - 6 - phenylimidazo [ 4 , 5 - b ] pyridine ( N - OH - PhIP ) were performed to induce mutations in the dihydrofolate reductase ( DHFR ) gene of a hemizygous Chinese hamster ovary ( CHO ) cell line ( UA21 ) .",
            "output": [
                "dihydrofolate reductase"
            ]
        },
        {
            "id": "task1481-74c9ccdce04d4a949c8101f82300a43c",
            "input": " Paclitaxel caused a rapid and transient increase in c - Jun NH2 - terminal kinase ( JNK ) activity , a proposed mediator of stress activation pathways .",
            "output": [
                "c - Jun"
            ]
        },
        {
            "id": "task1481-003a05e50db5412b97ebcec7878b863f",
            "input": " Signal transduction in fibroblasts stably transformed by [ Val12 ] Ras - - the activities of extracellular - signal - regulated kinase and Jun N - terminal kinase are only moderately increased , and the activity of the delta - inhibitor of c - Jun is not alleviated .",
            "output": [
                "c - Jun"
            ]
        },
        {
            "id": "task1481-08d6cfd3452b492ea213aa934756d6ba",
            "input": " Wild type MEKK1 enhances promoter activity and the activity can be inhibited by dominant negative MEKK1 , MEK1 , MEK7 , MEK3 , p38 / RK , and c - Jun .",
            "output": [
                "c - Jun"
            ]
        }
    ],
    "Instance License": [
        "MIT"
    ]
}